CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_AP014682	Lactobacillus hokkaidonensis JCM 18461 strain LOOC260 plasmid pLOOC260-2, complete sequence	1 crisprs	NA	1	0
NZ_AP014680	Lactobacillus hokkaidonensis JCM 18461 strain LOOC260	9 crisprs	WYL,cas3,DinG,DEDDh,csa3	1	7
NZ_AP014681	Lactobacillus hokkaidonensis JCM 18461 strain LOOC260 plasmid pLOOC260-1, complete sequence	0 crisprs	csa3	0	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP014682_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP014682_1

425-582

Orphan

Consensus_repeat	Method
AAACCCTTGCTACGAGCGGAAGTTCAAAAAATGAACTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP014682_1

>merge|NZ_AP014682|1|425-582|CRISPRCasFinder
AAACCCTTGCTACGAGCGGAAGTTCAAAAAATGAACTTCCGCGGGAGACCGTTAAAACCCTTGCTACGAGCGGAAGTTCAAAAAATGAACTTCCGCATAAGTTCGTTGACGACACCCCTCAAACCCTTGCTACGAGCGGAAGTTCAAAAAATGGACTT

>NZ_AP014682|1|1|425-582|CRISPRCasFinder
AAACCCTTGCTACGAGCGGAAGTTCAAAAAATGAACTT	CCGCGGGAGACCGTTAAAACCCTTGCTACGAGCGGAAGTTCAAAAAATGAACTTCCGCATAAGTTCGTTGACGACACCCCTC
AAACCCTTGCTACGAGCGGAAGTTCAAAAAATGGACTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP014682.1\|WP_024855764.1\|6268_6604_+\|CagC-family-type-IV-secretion-system-protein	unknown	unknown	gnl\|CDD\|374896
NZ_AP014682.1\|WP_041095822.1\|2378_2657_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014682.1\|WP_056993317.1\|2679_2907_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014682.1\|WP_156406657.1\|2227_2389_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014682.1\|WP_041095825.1\|5302_5614_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014682.1\|WP_041095824.1\|3157_5218_+\|MobA/MobL-family-protein	unknown	unknown	gnl\|CDD\|367473
NZ_AP014682.1\|WP_034528460.1\|6624_6987_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014682.1\|WP_041095821.1\|1507_2227_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|376885
NZ_AP014682.1\|WP_041095820.1\|1259_1457_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014682.1\|WP_041095826.1\|5652_6267_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP014682.1\|WP_041095824.1\|3157_5218_+\|MobA/MobL-family-protein	gnl\|CDD\|367473	pfam03389, MobA_MobL, MobA/MobL family. This family includes of the MobA protein from the E. coli plasmid RSF1010, and the MobL protein from the Thiobacillus ferrooxidans plasmid PTF1. These sequences are mobilisation proteins, which are essential for specific plasmid transfer.	2.89553e-102
NZ_AP014682.1\|WP_041095821.1\|1507_2227_+\|Fic-family-protein	gnl\|CDD\|376885	pfam02661, Fic, Fic/DOC family. This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.	0.000711697
NZ_AP014682.1\|WP_024855764.1\|6268_6604_+\|CagC-family-type-IV-secretion-system-protein	gnl\|CDD\|374896	pfam16943, T4SS_CagC, Cag pathogenicity island, type IV secretory system. T4SS_CagC is a family of putative pathogenicity island, type IV, conjugal DNA-protein transfer, secretory system proteins from Gram-negative bacteria.	2.41665e-43

>NZ_AP014682.1|WP_041095820.1|1259_1457_+|hypothetical-protein
MTTSSKEVETIDQLLADPWAVDIQDIWEQAAHNPDPDKRKLFDALHTYLLDKRQEQIINEKHFVI
>NZ_AP014682.1|WP_041095821.1|1507_2227_+|Fic-family-protein
MAKTRTYMDKYKFTAAENQRFARANFTKLVHTNARFEGVNTTLPQTQTIMDGMSVAGVPVEDVLTIVNLKRGWQYINAQNSPLTLTMEKQINKIVAAEDALVPGELRQGKGGVNLGSEDFFEPPLINEKQEQSFLQKILADPRTTITDKALTVMYHNMRQQIFWDGNKRTATLSANKIMIDGGAGLINVPLDKWDQWNELIANYYRTNDMTKIKQWTYDNGIQGLQIRANKKLSANELN
>NZ_AP014682.1|WP_156406657.1|2227_2389_+|hypothetical-protein
MYKQLKKTDKLELKLVEDEISKRTQNHLKDFAKNNLEVKPKNNPENKNDRPSY
>NZ_AP014682.1|WP_041095822.1|2378_2657_-|hypothetical-protein
MSNQYEKLVEQQARLKQKIEREDFKLRQSKYYENRQARKARSRRLIQKGALLEKYFQADNLSVEQTEELLKIFADYVNAHKPDKLKNDQPNN
>NZ_AP014682.1|WP_056993317.1|2679_2907_-|hypothetical-protein
MIGGIVMSQSNLEKQESKLKALNQKIKDEKNKIEQRLGKQIISQANLDYANLSNDQIKLLAKQFSEFLKVNSVDH
>NZ_AP014682.1|WP_041095824.1|3157_5218_+|MobA/MobL-family-protein
MAIFHMSFSNISAGKGRSAIASAAYRSGEKLFDNQEGRHYFYARSVMPESFILTPKNAPEWASNREQLWNEVEKNDRKSNSRYAKEFNVALPVELSESEQKELLTKYVKENFVDQGMVADVAIHRDHPDNPHAHVMLTNRPFNPDGSWGLKAKTQYIKDENGKQLLTKSGFPKQRKIWLVDWDKKEKINEWRHNWSTSVNQSLAQKNIPDRISEKSFVDQGIQETPTQHEGINSQRKNRKAFNQQVSAQRSAQAKYHNLDEKIRNREHFDALTDELSFSEKHTISHLSQQLKTYVDLEHLDDKQRMLFNWKNSLLIKHAVGEDVTKQLLTIDQQTTSLEQANQLLNKVVERATKKLYPELNFEQTTAAERRELIKETNSEQTIFKGGELAERLADIRNDLLTQQLLTFTRRPYTSWQLVNQQTQTIEKQLTTVLAKHGHQLDDLKPTDRGMLAAYQPNELEFISKAVKNLRVMREVKAVVQTQYNSILTTAFPDSDLDKLETIDKEQIYTAVVYYDPELKPLSTNDLSQLQQQPPVVFTSQQHQAGLNYLLGKMELKDIQNHRLQRVLKHDGTRQLFIGECGQDPKLDHKQIEMVQTRLKQQTTRFDQYRQAQVKDYRAINYHPTSPKNYLTNILDEALITILYAKNTDYLRKQQLRGLKETEWAMTKKQRQHQTRNRHEDGGRHL
>NZ_AP014682.1|WP_041095825.1|5302_5614_+|hypothetical-protein
MARQNKWISLSQAGIKLGHDRSYVSLWLRRHPNSMPEEYLMETGTVKLISLEGIEWIKKQSKKEGVLVSNKGANGDQHLEIRLLGVTLLIIHFTGRVRGKLVV
>NZ_AP014682.1|WP_041095826.1|5652_6267_+|hypothetical-protein
MKVESWQGINGKLVHDDQKAIVVDDEQALTDPKQLQAILDQDGQPIDEVRRAMMKKTVKRQLKTPPLKLRGWFNRHQDSQNAKKTEKLVSDKPTHQYKQIKNEMTFFGESFLEGFLGFYGLEVDNALGRYEHNVHVLETQELGQSEKEYYLATSENGRVNLATDPLPSQQIAEEQLNKFYQHEPEEMQAEQIQLRTTEDDGKEE
>NZ_AP014682.1|WP_024855764.1|6268_6604_+|CagC-family-type-IV-secretion-system-protein
MKFSKVKALATTGATAIYLGLMNAQVVLAADGGEVKSKLTSAGKTIQGILTGLVVLVGICVALFIIIKRMPDADDPREKSEVYHAVGRVAGLVALAAAIIWLLPWVYSLFT
>NZ_AP014682.1|WP_034528460.1|6624_6987_+|hypothetical-protein
MKKGKEFIFPENVDKDYGIWKDYTLKDFGYAALAGLVGLIFIAIPPYSLILVLIKIVIVVLAMTIVMAILTIRPVSARKNIKVRDNFKLKRRYANGQKLFYLKPKKRGELNAFEKEQNRQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP014682_1	1.1\|463\|82\|NZ_AP014682\|CRISPRCasFinder	463-544	82	NZ_AP014682	Lactobacillus hokkaidonensis JCM 18461 strain LOOC260 plasmid pLOOC260-2, complete sequence	463-544	22	0.732

1. spacer 1.1|463|82|NZ_AP014682|CRISPRCasFinder matches to NZ_AP014682 (Lactobacillus hokkaidonensis JCM 18461 strain LOOC260 plasmid pLOOC260-2, complete sequence) position: , mismatch: 22, identity: 0.732

ccgcgggagaccgttaaaacccttgctacgagcggaagttcaaaaaatgaacttccgcat	CRISPR spacer
ccgcgggagaccgttaaaacccttgctacgagcggaagttcaaaaaatgaacttccgcat	Protospacer
************************************************************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_AP014680

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP014680_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP014680_1

226394-226542

Orphan

Consensus_repeat	Method
AATTGATAAGTTCGCATTTTGAACTTATTGATTGCCGTTATTGTTTTAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP014680_1

>merge|NZ_AP014680|1|226394-226542|CRISPRCasFinder
AATTGATAAGTTCGCATTTTGAACTTATTGATTGCCGTTATTGTTTTAGCCCTAGGTATCTGCGGCTAGTTGCACGTTTTAAATAGAAAGGGAACAAAATAATTGATAAGTTCGCATTTTGAACTTATTGATTGCCGTTATTGTTTTAG

>NZ_AP014680|1|1|226394-226542|CRISPRCasFinder
AATTGATAAGTTCGCATTTTGAACTTATTGATTGCCGTTATTGTTTTAG	CCCTAGGTATCTGCGGCTAGTTGCACGTTTTAAATAGAAAGGGAACAAAAT
AATTGATAAGTTCGCATTTTGAACTTATTGATTGCCGTTATTGTTTTAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP014680.1\|WP_041092268.1\|227736_228603_+\|nucleoid-occlusion-protein	unknown	unknown	gnl\|CDD\|275105
NZ_AP014680.1\|WP_041092260.1\|222144_223509_+\|ISLre2-family-transposase	unknown	unknown	gnl\|CDD\|284250
NZ_AP014680.1\|WP_156406659.1\|214514_214658_-\|putative-holin-like-toxin	unknown	unknown	unknown
NZ_AP014680.1\|WP_041092266.1\|226856_227582_+\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NZ_AP014680.1\|WP_041092277.1\|230809_231910_+\|redox-regulated-ATPase-YchF	unknown	unknown	gnl\|CDD\|236583
NZ_AP014680.1\|WP_041092255.1\|217465_218503_+\|lactonase-family-protein	unknown	unknown	gnl\|CDD\|378416
NZ_AP014680.1\|WP_041092275.1\|230303_230495_+\|DUF951-domain-containing-protein	unknown	unknown	gnl\|CDD\|377606
NZ_AP014680.1\|WP_041092253.1\|215201_217004_+\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234752
NZ_AP014680.1\|WP_041092263.1\|225358_226279_+\|ribonucleoside-hydrolase-RihC	unknown	unknown	gnl\|CDD\|182713
NZ_AP014680.1\|WP_041092287.1\|233705_234119_+\|protein-export-chaperone-SecB	unknown	unknown	unknown
NZ_AP014680.1\|WP_041092282.1\|232850_233408_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014680.1\|WP_041091960.1\|212888_214253_+\|ISLre2-like-element-ISLho1-family-transposase	unknown	unknown	gnl\|CDD\|284250
NZ_AP014680.1\|WP_041092262.1\|223984_225244_+\|nucleoside-permease	unknown	unknown	gnl\|CDD\|224883
NZ_AP014680.1\|WP_041092256.1\|219297_220494_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|224292
NZ_AP014680.1\|WP_041092273.1\|229377_230259_+\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|275105
NZ_AP014680.1\|WP_041092271.1\|228620_229388_+\|ParA-family-protein	unknown	unknown	gnl\|CDD\|379293
NZ_AP014680.1\|WP_041092285.1\|233457_233694_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014680.1\|WP_041092258.1\|220803_221631_-\|DUF368-domain-containing-protein	unknown	unknown	gnl\|CDD\|224946
NZ_AP014680.1\|WP_041092280.1\|231939_232710_+\|DUF1129-domain-containing-protein	unknown	unknown	gnl\|CDD\|368981
NZ_AP014680.1\|WP_041092251.1\|211618_212707_+\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|236329

Protein	Function_ID	Function_description	E-value
NZ_AP014680.1\|WP_041092268.1\|227736_228603_+\|nucleoid-occlusion-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	1.61434e-125
NZ_AP014680.1\|WP_041092260.1\|222144_223509_+\|ISLre2-family-transposase	gnl\|CDD\|284250	pfam06782, UPF0236, Uncharacterized protein family (UPF0236).	3.67085e-33
NZ_AP014680.1\|WP_041092266.1\|226856_227582_+\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	5.1518e-85
NZ_AP014680.1\|WP_041092277.1\|230809_231910_+\|redox-regulated-ATPase-YchF	gnl\|CDD\|236583	PRK09601, PRK09601, redox-regulated ATPase YchF.	0
NZ_AP014680.1\|WP_041092255.1\|217465_218503_+\|lactonase-family-protein	gnl\|CDD\|378416	pfam10282, Lactonase, Lactonase, 7-bladed beta-propeller. This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyze 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.	1.038e-109
NZ_AP014680.1\|WP_041092275.1\|230303_230495_+\|DUF951-domain-containing-protein	gnl\|CDD\|377606	pfam06107, DUF951, Bacterial protein of unknown function (DUF951). This family consists of several short hypothetical bacterial proteins of unknown function. Structural modelling suggests this domain may bind nucleic acids.	8.64537e-32
NZ_AP014680.1\|WP_041092253.1\|215201_217004_+\|threonine--tRNA-ligase	gnl\|CDD\|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0
NZ_AP014680.1\|WP_041092263.1\|225358_226279_+\|ribonucleoside-hydrolase-RihC	gnl\|CDD\|182713	PRK10768, PRK10768, ribonucleoside hydrolase RihC; Provisional.	0
NZ_AP014680.1\|WP_041091960.1\|212888_214253_+\|ISLre2-like-element-ISLho1-family-transposase	gnl\|CDD\|284250	pfam06782, UPF0236, Uncharacterized protein family (UPF0236).	3.86186e-30
NZ_AP014680.1\|WP_041092262.1\|223984_225244_+\|nucleoside-permease	gnl\|CDD\|224883	COG1972, NupC, Nucleoside permease [Nucleotide transport and metabolism].	1.69433e-113
NZ_AP014680.1\|WP_041092256.1\|219297_220494_+\|ATP-binding-protein	gnl\|CDD\|224292	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only].	2.31427e-91
NZ_AP014680.1\|WP_041092273.1\|229377_230259_+\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	1.60104e-81
NZ_AP014680.1\|WP_041092271.1\|228620_229388_+\|ParA-family-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	2.71095e-96
NZ_AP014680.1\|WP_041092258.1\|220803_221631_-\|DUF368-domain-containing-protein	gnl\|CDD\|224946	COG2035, COG2035, Predicted membrane protein [Function unknown].	1.69472e-42
NZ_AP014680.1\|WP_041092280.1\|231939_232710_+\|DUF1129-domain-containing-protein	gnl\|CDD\|368981	pfam06570, DUF1129, Protein of unknown function (DUF1129). This family consists of several hypothetical bacterial proteins of unknown function.	5.43373e-73
NZ_AP014680.1\|WP_041092251.1\|211618_212707_+\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|236329	PRK08664, PRK08664, aspartate-semialdehyde dehydrogenase; Reviewed.	0

>NZ_AP014680.1|WP_041092263.1|225358_226279_+|ribonucleoside-hydrolase-RihC
MALKIIMDTDPGIDDAAALTMAINDPALDLKLVTAVAGNVTVDKTTANALKIVHFFGKDKEIPVAAGAKQPLIKPFEDAARIHGASGMPGYDFGDDYGHAIDKSAVEALHDEIMAADEPITLVPTGSYTNIALLFSQYPEVKANIKEIIAMGGTLQEGNMTSAAEFNCFTDPHAAKVLYDSGVPIVMVGLDITLKALLTADTLDKLANLNKTGKMLHGLITHYGDGGPEGIPMHDVNTIFYLLHPEAITTKEMWVDVQTEGPAMGETVGDIRGAYHDGKTNAKVCVDIDAAAFNKWFLEEIASIKD
>NZ_AP014680.1|WP_041092262.1|223984_225244_+|nucleoside-permease
MYVFINILGLIVFLGIAFLFSKKKKEIHWRSIAIMVAINLLLAWFFTSFSVGRDAVKGAAAGFNWLVEVSYQGIIFALPNWVTTNYGGTLGNGGSMNFITSALLPILMIVPLFDILTYIGVLPWIIKWIGRGLSYITGQPKFESFFAVEMMFLGNTEVLAISGLQLRQMKAERNLTLAMMSMSCVTASILGAYTQMVPGQFVLTAVPINIINSIIVTSMLNPVDVPAEEDTVAKVGQVGEEDGGDAEANGKREPFFSFLGDSILGAGRLILIITANVIAFVALAALIDKILGLFWKPLSLESILGTIMFPFAWLLGLPVHQAWTLSQDMGLKLVTNEFVVMGRVAGDVINGYAPHLRAVLTVFLTSFANFGTVGMIIGAFKGLVNREKNDLIAANVGYMLLSGILVSLLSAGFVGLFVW
>NZ_AP014680.1|WP_041092260.1|222144_223509_+|ISLre2-family-transposase
MFILADFIDSLKNLDSLFDLEEQVIRCLREMFQEIVSKYLIQLDETLVSQIPSDHTFVNRQPRTINFMFGAVSFERRCYRNTDGTNYFPLDTHLKLVSRKRFSPYFKSVVSKIGQMTTMRNTADMINLASQTDISAWTVDKIVREMADIVAVEEETLDKEIVHRKKVDNLVIEGDAFEVRERGKQRVSVHHYRVYESTNYGPVNKREFIETNHLKARKQVCDYLEAHYKLSEMVVFLASDAGPGYDPISMRELVPGAKKVEYVIDRYHFIRKFEQTIGLQNPLSRKATAAIRGYNLNQLEAILDTFESQITTGKDSEKLTKLRHYLSRNWKYIKRPKDRDYKYMGKLGSVESSHRAFTYRLKKQGKSWSKEGLQAMLVLILARVNRHLNQDLSSGLRRLRELKIEVSLESIKSIRFTDLNRKIRSQHIGVKIGNITVDSSTSSPIGAMAKAYSR
>NZ_AP014680.1|WP_041092258.1|220803_221631_-|DUF368-domain-containing-protein
MNNHRPQSWLLRALKGALIGTGFILPGISGGALAAVFGIYEQLIDFLAHPFRRLKQNIFFFLPVGIGAIGGIFLLSFAISYLLGNFEAIILWFFIGAIVGTIPALWKDAGQKGRSAGDVFLMMAAFVAMLLFLLFGAPLFSAIEPKFSSWVLGGALIGLGLVIPGLSPSNFLIYLGLYKAMTDAIKVGDMSVITPLILGVLLVIAILSKLMDYLFRTFYPQLFHLILGIVAASTVMIVPSETIHMSLGALAASAVMLGLGTWLGWWMSRLDQATR
>NZ_AP014680.1|WP_041092256.1|219297_220494_+|ATP-binding-protein
MIERPKYLAELIEFKDTDLIKIITGVRRSGKSVLLMLYRDYLLKQGIEARDIIYINFEDYQMQLVQTENQLRKILDKRLNKNRRQYILLDEIQNVSGWQRVINGVRVSFNCDIVITGSNAKMLSGELATLLSGRYVEIPIYPFSFKEFLNAKNISSDSREIDSAFTEYEKFGGFPAAILANDAVKDQVLKGIYDAVILNDVSMRGNVRDVTILRAVVGFLADNTGQLVQPNKIANTLKSEGMRVSPHTITRYLELLENAFLFYHVQQYDLRGRQYLKTTGKYFIADSGLRRIAVGRRAGNYSNQLENIVYIELKRRGYIINVGKLGSKEIDFVARKDDDILYVQVTYELPDNKHETNNLLKLNDNYQKIVITQKYYEVTQIDGIPIINIVDWLLDRKS
>NZ_AP014680.1|WP_041092255.1|217465_218503_+|lactonase-family-protein
MEKYFLGTYTHRVSKGIYSFDFDPSNGQASNLKLVHEAVNPFYLALGSEHILYCINNNNDVTKPGGIMAIDVDNPSVVKASTYDSAISGTYIAYNDVKRLIYLANYDINELSLYHVGHNRIELQDRTHNNGVVGPKTEQQDGPHPHFINQTPDGRLPVCDLGLDRIFTYDITGKNQFELVATLVLPAGFGPRHLRFNKEKNIAYAVGELSSEVASLSYDQVTGEFKIIDINATIPASWTKHNGAAAIRISGDNRFLYISNRGYNSIAVFSIGDHLKLIQNVAAGGDFPWDINFSQTEDFVLVANQRSDNLSVFSRNAKTGTLKLVNNHFWLPEPLAIVAAEKPLK
>NZ_AP014680.1|WP_041092253.1|215201_217004_+|threonine--tRNA-ligase
MAQVQVLAADGSVKKIDRDSPEGLQALRQTTALLLAASLHQKFDKIRLGAAVASDDGFYVDSDKDEIQVSADELSGLEDSIKKFAKDDAKIERVEVALNDALAQVKADPYQTELFKEAAKGDKVSLFKVGDFATIAGEDVLCYVDAVKNFKVLSVAGAYWQGKSSNPMLQRIYGTVFYKKDALEADLQARQEARERDHRVIGNDLDLFFVDPKVGAGLPYWMPKGATIRRVIERYIIDKEVANGYKHVYTPILMNLDVYKTSGHWQHYREDMFPPMDMGDGEQLELRPMNCPSHIQIYKHHIRSYRELPLRIAELGMMHRYEKSGALSGLQRVREMTLNDGHTFVAPNQIQDEFKSILKLMIEVYHDFDISDYSFRLSYRDPKNTDKYFDDDEMWNNAQTMLKQAMDDLGLDYYEAEGEAAFYGPKLDVQTKTALGNDETLSTIQLDFMLPKQFDLHYVGEDGQQHRPIMIHRGLVSTMERFTAYLTEMYKGAFPTWLSPEQVKIIPVKEEIHADYAESLRKELAAAGIRVSIDHRNEKMGYKIREAQTQKVPYTLVVGDKEVKDTGVTVRKYGEEKQVSKSKQDFLDEILGDLSSYSRE
>NZ_AP014680.1|WP_156406659.1|214514_214658_-|putative-holin-like-toxin
MPCGINLKKGPVVVSVTDAILLMLDFGGLILMLISVIVAIVVAIIKR
>NZ_AP014680.1|WP_041091960.1|212888_214253_+|ISLre2-like-element-ISLho1-family-transposase
MFILADFIDSLNNLDSLFDLEEQVIRCLREMFQEIVSKYLIQLDETLVSQIPSDHTFINRQPRTINFMFGAVSFERRCYRKTDGTNYFPLDTHLKLVSRKRFSPYFKSVVSKIGQMTTMRNTADMINLASQTDISAWAVDKIVREMADIVAVEEETLDKKIVHRKKVDNLVIEGDAFEARERGKQRVSVHHYRVYESTNAGPVNKREFVETNHLKARKQVCDYLEVHYKLSEMVVFLASDAGPGYDPISMRELVPGAKKVEYVIDRYHFIRKFEQTIGLQNPLSRKATAAIRGHNLNQLEAILDTFESQITTGKDSEKLIKLRHYLSRNWKYIKRPKDRGYKYMGKLGSVESSHRAFTYRLKKQGKSWSKEGLQAMLVLILARVNRHLNQDLSSGLRRLRELKIEVSLEPIKSIRFTDLNRKTRSHHIGVKIGNITVDSSTSSPIGAMAKAYSR
>NZ_AP014680.1|WP_041092251.1|211618_212707_+|aspartate-semialdehyde-dehydrogenase
MDKLKVGVIGATGMVGQRYVSLLENHPWFEVVVVAASAHSAGKTYAESVHGRWKMENPVPDSVKDLVLLDVKDVKTIADQVDFVFSAVSMSKDEIRAIEEEYAKTETPVVSNNSAHRWTPDVPMIVPEINPEHSEIIKYQRERLGTKRGFIAVKPNCSIQSYTPALSAWRKFEPTQVIATTYQAISGAGKTLEDAPEIVGNVIPYISGEEAKSENEPLKIWGHVDDEKKEIVSAESPVITSQCLRVPVLYGHTAAAFVNFKQNPTKEELIEALESYRGEPQKLGLPSAPKQFIQYMQQDDRPQVRYDVNFENGMGISIGRLRPDKIFDWKFIGLSHNTSRGAAGGAILCAELLKEQGYIEKK
>NZ_AP014680.1|WP_041092266.1|226856_227582_+|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MNPQQFRQALAKQQIMLSDQQMQQFALYYDLLVKGNEQLNLTSITEQGEVYLKHFYDSMTPAFSFPALKTDSLTLCDVGAGAGFPSLPLKIAFPNLKITIIDSLNKRIIFLEQLVAQLGLSDVTLVHDRAETFGAKTSLHREFYDVVTARAVARLSVLSELCLPLVKLNGTFIALKASQADDELAQAKVAIETLGANVSAVDQLVLPQSDEPRTIIVMNKVDQTPDKYPRRPGVPAKKPIG
>NZ_AP014680.1|WP_041092268.1|227736_228603_+|nucleoid-occlusion-protein
MAFSIFGSQKNKNQKATNQVVEVDITKITPNRFQPRKVFDATAIKELAETIQNHGLLQPIIVREYEPSKYEIIAGERRFRAVNELKWEKIPAIIEKMNDKETASLALIENLQREQLSSVEEAQAYRSLMDLNHLTQTALAQGMGKSQSAVANKLRLLKLIAPVQNAILDRRITERHGRALLELNDDQQREALMEIVNSKLTVKQTEELVAEMTGKARTLAEETKAPAAKPKKRARRSNSKGLTADTRVAVNTIKESVKLIRDNGMKIKTRESDEDDHYEIVIEIPKQK
>NZ_AP014680.1|WP_041092271.1|228620_229388_+|ParA-family-protein
MGYVIALANQKGGVGKTTTSVNLGACLAQMGQRVLLIDIDPQGNATSGTGIQKATIEQDIYDVLINEIPLKDVILKTNHAGLDIVPATIQLSGAEVELTSMMAREIRLKDEIGAITDQYDYILIDCPPSLGLLTINAFTASNSILIPVQSEYYALEGLSQLLNTIKLVQKHFNPALKIEGVLLTMFDARTNLGQQVNAEVQKFFGEQVYDTIIPRNVRLSEAPSHGLPIIDYDPKSKGAQVYMALAKEVLAAHGK
>NZ_AP014680.1|WP_041092273.1|229377_230259_+|ParB/RepB/Spo0J-family-partition-protein
MANNKKGLGRGIEALFEDNEVSAAEENVQEIGLDEIRPNPYQPRRTFDTKALEELASSIAKAGVFQPIIIRKPNKKMKRYEIIAGERRFRASKLAKKQTIPAIVREMNDEEMMEVAVVENLQREDLTPLEEAQAYETLMEKLSLTQAQVSERLGKSRPYIANYLRLLGLPKMVKEMLQKEQLSMGQARTLLGLKDKDKLVALARRTVEQNLTVRQLEQLVSQMNGVSKNKKTGKKTNKSVFVRAAEDQLQSKFGTKVAVAQSTNQKGAGKIEIPYLSDDDLTRILELLEIDLG
>NZ_AP014680.1|WP_041092275.1|230303_230495_+|DUF951-domain-containing-protein
MYDKGDVVMMKKPHPCGTNEWEIIRMGADIKIKCLGCGHIVMLTRREFEKRMKKVLKSAEQDD
>NZ_AP014680.1|WP_041092277.1|230809_231910_+|redox-regulated-ATPase-YchF
MALTAGIVGLPNVGKSTLFNAITKAGAEMANYPFATIDPNVGMVEVPDARLDRIQELIPAKKVVPTTFEFTDIAGIVKGASKGEGLGNKFLENIRQVDAIVHVVRAFDDDNITHVTGKVDPVDDIETINLELGLSDLEAVDKRLTKVERAAKGSDKEAKAELAVLEKIKPVLEAGKGVRTIDFDEDEMPIVKGLFLLTSKPVLYVANISEDDMADPDGNKYIQTIRDYVKDENAQVIGVAAASEEEIAEMDDADKAELLEMEGVKEPGLNRLIRASYSLLGLETFFTAGGKETKAWTYKAGTKAPQAAGIIHSDFERGFIRAEIMSFDDLDKLETQAAVKEAGKLRAEGKEYVMQDGDIVEFRFNV
>NZ_AP014680.1|WP_041092280.1|231939_232710_+|DUF1129-domain-containing-protein
MSEENQPRNAAAGSQQREHVRENHANTHRQFGDSGLTKRNEEFMFQLNKQLDEQGMKADKKPAAIQETLDALIAGQKTGATAKQLFGTPTKKADDLIHGPAKNGNQQQSSFWLLAADNGLMFFNIFTLLFGVMGIFQPKSLQTQQTGTTGIVAIILVGVVGGMLFAWITQILTPPAKKDKKPIWYRIIAVIGALLAWVAVYFVASLLPNVINPQLPAWAYIVLGVLGFVGDLYLRRKFHIVGGAFGSPRQQQNRRR
>NZ_AP014680.1|WP_041092282.1|232850_233408_+|hypothetical-protein
MFGFHGTGIDNATKIMNNGFTIAKSNKVPNDLGTGVYFYINSAFTFSPIMMAKNYSIVYKRISKAKITVLQAEIDEEATLIDFDLKSNLIELVKYRDANFDKIKNILNTVEKGNGLAARGNLDGIVIELFKTYLEEKYNVRVDGVKKNTFTPQHDLYKYKQSNMPNGRELCVYNLNRISNLKICE
>NZ_AP014680.1|WP_041092285.1|233457_233694_+|hypothetical-protein
MELILKNIISDTETYEMTENDILEGLIKLGYAEKNFFNIVSESDESLNISKSSIEDVREYDMQNDFFSSKQSDLAIAA
>NZ_AP014680.1|WP_041092287.1|233705_234119_+|protein-export-chaperone-SecB
MAEKRERKLVPIEFNGYKIVSLKYGELKETEEKLSAKLNVKFGLTKGNEKGIVELESFFVNHNKKVQGTIIVRGNFTLDGSLSDDDAQKFLGQNGAAMLYPYVRTIISVVTSLDDQNVSVLPSLNFVEAYQKINKVE

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Crispr_ID: NZ_AP014680_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP014680_2

496459-496576

Orphan

Consensus_repeat	Method
ATTTACCATGTAAGGGTCATTATTTTGTTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP014680_2

>merge|NZ_AP014680|2|496459-496576|CRISPRCasFinder
ATTTACCATGTAAGGGTCATTATTTTGTTATACGTAGTTATCTGCGGTTGCCGAACACGTTTATTCTATCAAAGTAGGAAGAATGGTGAATTTCCATGTAAGGGTCATTATTTTGTTA

>NZ_AP014680|2|2|496459-496576|CRISPRCasFinder
ATTTACCATGTAAGGGTCATTATTTTGTTA	TACGTAGTTATCTGCGGTTGCCGAACACGTTTATTCTATCAAAGTAGGAAGAATGGTG
AATTTCCATGTAAGGGTCATTATTTTGTTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP014680.1\|WP_041092695.1\|504428_504983_+\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|238245
NZ_AP014680.1\|WP_041092687.1\|500297_501074_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223488
NZ_AP014680.1\|WP_041092673.1\|489802_490324_+\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|223340
NZ_AP014680.1\|WP_041092697.1\|505148_505643_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014680.1\|WP_041092693.1\|502787_504215_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_AP014680.1\|WP_041092676.1\|491734_492583_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381297
NZ_AP014680.1\|WP_041092682.1\|496093_496420_+\|MazG-like-protein	unknown	unknown	gnl\|CDD\|212150
NZ_AP014680.1\|WP_052467255.1\|491240_491591_-\|iron-sulfur-cluster-biosynthesis-family-protein	unknown	unknown	gnl\|CDD\|366687
NZ_AP014680.1\|WP_041092674.1\|490332_491184_+\|DUF3114-domain-containing-protein	unknown	unknown	gnl\|CDD\|337977
NZ_AP014680.1\|WP_041092689.1\|501070_501781_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223487
NZ_AP014680.1\|WP_052467256.1\|494607_495492_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_AP014680.1\|WP_041092681.1\|495542_496094_+\|DUF1697-domain-containing-protein	unknown	unknown	gnl\|CDD\|377954
NZ_AP014680.1\|WP_041092684.1\|498444_499323_+\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223633
NZ_AP014680.1\|WP_041092680.1\|493642_494611_+\|glycosyltransferase-family-8-protein	unknown	unknown	gnl\|CDD\|133037
NZ_AP014680.1\|WP_041092691.1\|501786_502407_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341361
NZ_AP014680.1\|WP_041092686.1\|499332_500295_+\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119323
NZ_AP014680.1\|WP_041092678.1\|492824_493592_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_AP014680.1\|WP_041092683.1\|496855_498043_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380570
NZ_AP014680.1\|WP_041092671.1\|489253_489643_-\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|184579
NZ_AP014680.1\|WP_041092698.1\|506247_506772_-\|lipoprotein	unknown	unknown	gnl\|CDD\|180584

Protein	Function_ID	Function_description	E-value
NZ_AP014680.1\|WP_041092695.1\|504428_504983_+\|cysteine-hydrolase	gnl\|CDD\|238245	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.	2.82054e-49
NZ_AP014680.1\|WP_041092687.1\|500297_501074_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223488	COG0411, LivG, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	6.11105e-117
NZ_AP014680.1\|WP_041092673.1\|489802_490324_+\|dihydrofolate-reductase	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	8.516e-30
NZ_AP014680.1\|WP_041092698.1\|506247_506772_-\|lipoprotein	gnl\|CDD\|180584	PRK06481, PRK06481, flavocytochrome c.	3.77948e-05
NZ_AP014680.1\|WP_041092693.1\|502787_504215_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	8.5217e-72
NZ_AP014680.1\|WP_041092676.1\|491734_492583_+\|aldo/keto-reductase	gnl\|CDD\|381297	cd19071, AKR_AKR1-5-like, AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.	8.0296e-119
NZ_AP014680.1\|WP_041092682.1\|496093_496420_+\|MazG-like-protein	gnl\|CDD\|212150	cd11543, NTP-PPase_u6, Nucleoside Triphosphate Pyrophosphohydrolase EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea. This family corresponds to a group of uncharacterized hypothetical proteins from bacteria, showing a high sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, members in this family consist of a single MazG-like domain.	1.02713e-25
NZ_AP014680.1\|WP_052467255.1\|491240_491591_-\|iron-sulfur-cluster-biosynthesis-family-protein	gnl\|CDD\|366687	pfam01521, Fe-S_biosyn, Iron-sulphur cluster biosynthesis. This family is involved in iron-sulphur cluster biosynthesis. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins.	9.74953e-24
NZ_AP014680.1\|WP_041092674.1\|490332_491184_+\|DUF3114-domain-containing-protein	gnl\|CDD\|337977	pfam11311, DUF3114, Protein of unknown function (DUF3114). Some members in this family of proteins with unknown function are annotated as cytosolic proteins. This cannot be confirmed.	1.75338e-37
NZ_AP014680.1\|WP_041092689.1\|501070_501781_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	3.43635e-122
NZ_AP014680.1\|WP_052467256.1\|494607_495492_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	7.60117e-19
NZ_AP014680.1\|WP_041092681.1\|495542_496094_+\|DUF1697-domain-containing-protein	gnl\|CDD\|377954	pfam08002, DUF1697, Protein of unknown function (DUF1697). This family contains many hypothetical bacterial proteins.	3.28499e-37
NZ_AP014680.1\|WP_041092684.1\|498444_499323_+\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|223633	COG0559, LivH, Branched-chain amino acid ABC-type transport system, permease components [Amino acid transport and metabolism].	5.7997e-86
NZ_AP014680.1\|WP_041092680.1\|493642_494611_+\|glycosyltransferase-family-8-protein	gnl\|CDD\|133037	cd04194, GT8_A4GalT_like, A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.	4.43537e-68
NZ_AP014680.1\|WP_041092691.1\|501786_502407_+\|CBS-domain-containing-protein	gnl\|CDD\|341361	cd04584, CBS_pair_AcuB_like, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the ACT domain. The putative Acetoin Utilization Protein (Acub) from Vibrio Cholerae contains a CBS pair domain. The acetoin utilization protein plays a role in growth and sporulation on acetoin or butanediol for use as a carbon source. Acetoin is an important physiological metabolite excreted by many microorganisms. It is used as an external energy store by a number of fermentive bacteria. Acetoin is produced by the decarboxylation of alpha-acetolactate. Once superior carbon sources are exhausted, and the culture enters stationary phase, acetoin can be utilised in order to maintain the culture density. The conversion of acetoin into acetyl-CoA or 2,3-butanediol is catalysed by the acetoin dehydrogenase complex and acetoin reductase/2,3-butanediol dehydrogenase, respectively. Acetoin utilization proteins, acetylpolyamine amidohydrolases, and histone deacetylases are members of an ancient protein superfamily.This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce acetoin as an external carbon storage compound and then later reuse it as a carbon and energy source during their stationary phase and sporulation. In addition these CBS domains are associated with a downstream ACT (aspartate kinase/chorismate mutase/TyrA) domain, which is linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	4.94156e-60
NZ_AP014680.1\|WP_041092686.1\|499332_500295_+\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119323	cd06581, TM_PBP1_LivM_like, Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	1.87935e-72
NZ_AP014680.1\|WP_041092678.1\|492824_493592_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	2.20376e-11
NZ_AP014680.1\|WP_041092683.1\|496855_498043_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380570	cd06347, PBP1_ABC_LivK_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.	1.12946e-133
NZ_AP014680.1\|WP_041092671.1\|489253_489643_-\|CrcB-family-protein	gnl\|CDD\|184579	PRK14231, PRK14231, fluoride efflux transporter CrcB.	8.62996e-23

>NZ_AP014680.1|WP_041092682.1|496093_496420_+|MazG-like-protein
MEIKEFKARSNHIRAAYHQLEVKQDGHPWNTEQDALAFLTDAALVGRLVMDKQGSWPSEDNMFSLDYKIAESMWWLNSIATANNIDIETALKSFLEAREKYTSVNNRD
>NZ_AP014680.1|WP_041092681.1|495542_496094_+|DUF1697-domain-containing-protein
MKYLLLLRGINVGGHSRVAMQELKLALTNVGFNRVTSYINSGNLIFESTLSQQKISDKIEQLLKNNYKFPIVSMVISEVEYRSDFVNLPKWWGEDEQLRHNALFLLPTFDKNGFDDIRNRITEYDQVEFREHVILWTSTLKKDFSKSLYSKLMKEKFYHDISIRNRNTALKLLALLSEKSGEQ
>NZ_AP014680.1|WP_052467256.1|494607_495492_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MIDRMLLGDDRDSVIANIKKAANEGRFNDKVENGDPVLSVEQQDLVLTNYLKKHDGLAYKFNNLISRVTVNSALKFITRTVKIEGLDNIKAVTSGAIVTSNHFSPLDTAYVHKAVVKAGKSRLYIVSELENLKMQGLLGYIMNYYDTMPISTNANYMGREFPELVKNILDRDQFVLIYPEQEMWFNYRKPRPPKRGAYYYAAKFKVPIISCFVEMQNQAKVKDSEFGDVAIIIHILNPIYPDPHKSEHENSILLMNQDYAQKSTAYEKVYNKKLDYKFADADIAGWYPPEHLDN
>NZ_AP014680.1|WP_041092680.1|493642_494611_+|glycosyltransferase-family-8-protein
MDTQKETIPLFFSVDDGYVPFLAVALKSIIDNASKDYNYEGIVLHEGISKQNQAEIAAITADNFSVKFVSMKGKLNEQMKGEQAKLRGDYFTFTIFFRLFIADMFPEYDKAIYLDADIIVPGDVSELYNIELGSNVVGAISDLFISKNSETIEYSESAMGVPITDYVNSGVLLMNLAQLRKTSLSQVFLRLYNKYHFETIAPDQDYLNVIGHDKIKHLGFEWNTQTAALVHENEVATPKIIHYNLFRKPWYYKHVIFEDYFWKYAKSLGYESEFVEMQNNYSQEQAVADQDNLTGLLSMAAKIDDGDITFKKIQERGEQITI
>NZ_AP014680.1|WP_041092678.1|492824_493592_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MKSELKKTIYYYSYTDDLVTNKGQTSQLPNNYKWLHHNIFYRGFGFIIFVIARFIGVCYCKLCLHVTVKNKQILKNYRKQGIFLYGNHTQAVGDVFVPMLIAYPKRSFTVASAANLGVPVVGKIINFGGIVIPDTIRQMRYFNQAIIQRINENHPIVIFPEAHVWPYYTKIRPFTDTSFHYPVQNNVPSFCMTTTYQKRKHGNKPKITVYVDGPFLPDETLAKKARQKKLCADIYDCMVDRTKNNTYEYIKYQRQ
>NZ_AP014680.1|WP_041092676.1|491734_492583_+|aldo/keto-reductase
MSILTETFTLENGIQIPKVGFGTWQIPGGKTAYDAVVSALKTGYRHVDTAQAYANESSVGKAIKDSGIKRENIFVTSKLPAEIKTYDGALAAFDKTMDNLGLKYLDLYLIHAPWPWGQIGTDHDRDNVETWKAMEKIYQSGRVKAVGVSNFNVHDLKNIMEKATVIPFVDQIQYYVGYTEPKITKFAQEQGMLVEAYSPLATGDLINNPKIKEMAAKYKVSVAQLALRFCIENGVLPLPKATSQAHIEANAQLDFSISADDMAILNSMPDAAPSHMHNATQG
>NZ_AP014680.1|WP_052467255.1|491240_491591_-|iron-sulfur-cluster-biosynthesis-family-protein
MKLTVSKEALTILQPKLRDHTNLLLSYDDGVGPYSHHGLEALQIAFKLIFITDQMPMDDYNLKIESNLGPIYVKEYSTEFLGTNLKIQFNTNYHLFTLSDDGEIIEDNLQIEDLRT
>NZ_AP014680.1|WP_041092674.1|490332_491184_+|DUF3114-domain-containing-protein
MVDNEHGLVGSPAYTSWMKQKIENDSTKDNCRNILIQMFNQLGAHLNSLGDLELPADFDSDLNPNSIFFSTLARIVQVAFPAGLAEGSIQDIKLRKMVHQLRYYLDVFNVSYLRRQYSDVENDRQRLILYDLDCYQNRQQMSHSEPARLHNKLDRQLKIPVMDGWNIKRVYDFHVEFILDRHGRFVYLDLQQLGKQLPGQIINCSSFNYADRNDDQHKKLDIHYNARKSPLSQSKDPGLRSSFNSHTYSPKKDNLANTIREIWFQLQFDLCRRWELLKRRIKN
>NZ_AP014680.1|WP_041092673.1|489802_490324_+|dihydrofolate-reductase
MRQIQFYGAMSLDGYLATTKHNLQWLLDTPGGDKANSELFFDQIDTTIMGRKTYDVSKELMNNEPFYPDKTNYVLSNNRHGREADAIYYNNSPVKLVQDLLDQSGGNIWIVGGGQIVTDLLAANLIDEWWIQIAPVILGDGIRLFANGDYSTRLELLNVNQYDQLAELHLRRK
>NZ_AP014680.1|WP_041092671.1|489253_489643_-|CrcB-family-protein
MKKYLAVLIFGTFGGICRTAISNLFVLSNHFPLGTLIVNLIGCFLFSIAIHYIALTFPLNSDIISGLSVGFVGAFTTFSGLSVDSIILLHSHEYLLLGIYNSASIIGGIGFAILGILTSQHLISRREHW
>NZ_AP014680.1|WP_041092683.1|496855_498043_+|ABC-transporter-substrate-binding-protein
MRAKKLMRVLGTVMLASTLVLAGCSSSAASGGNKQSGNTIKLGGNFELSGSAAAYGEAMQNGVKLAVKQINADGGVKVGSKKMKIKLIQKDNKSDNSSAASVATNLATTSKVNAVVGPITSGAGLAALPNYTKAKVPYITPGGTQDSLTVQKNGKVQPYMFRSCFEDSYQGKALAKYVYGNMKLKKVAILGDKSTDYAQGLTKAFKKQFKGQVVSTQYYQSGDKDFNTLLTKLKSKDFDAIFVPGYYSEAGLIVKQARQMGITQPIVGADGFADPKLVKIAGKKNATNIYYTTHFDAKANTNAKATAYMKAYKSQYHQDAGTFDALAYDATYMFKDAIENEKSADSTKIATGLSKLKNFKGVTGTISIDKKHNPQKQVIIAKVVNGEEQSATAVK
>NZ_AP014680.1|WP_041092684.1|498444_499323_+|branched-chain-amino-acid-ABC-transporter-permease
MSTVLQQLVNGLSLGSIYALLALGYTMVYGIIKLINFAHGDIYMLGAFWGYYVINQLHFNFWLALASSMLFCALVGVVIEYLAYRPLRNSPRIAALITAIGVSFLLENGMAYMFSSNVRSFPQVMKVTQYHLGSVSISNIQILILVVSIVLMILLQLIVQRTKMGKAMRAVSVDPDAAQLIGINIDRTISFTFALGSAMAGAAGVLIGLYYNSIDPLMGMTPGIKAFVAAVLGGIGLIPGAAIGGFVIGLLETLMQSIGFSAYKDAAVYAVLIIILLIKPAGILGKKIKEKV
>NZ_AP014680.1|WP_041092686.1|499332_500295_+|branched-chain-amino-acid-ABC-transporter-permease
MKKNLKYNLTWLAIMVVGYVVINLLEFVGVIDQFGENTMVLIGINIILATGLNLIIGFSGQFSLGHAGFMAIGAYVCALITSSVSTPMGMAIGMIAGAAVSALVALIVGIPTLRLDGDYLAIATMGVAEIIRIILNNMKITNGPAGLYNIPLLATWPVVYFMVCVTTLIIVNFIHSRDGRAVMSVRENEIASESMGVNTTKWKVMAFVIGAATAAIGGALHANYIQTIAPTDFGIMESINILIIVVLGGIGSITGTFVAAVVLGLLDMILQNFGTLRMVLYSLALILLMVFKPSGLLGTWEFSVRNLFNRFTRSKQKGDA
>NZ_AP014680.1|WP_041092687.1|500297_501074_+|ABC-transporter-ATP-binding-protein
MTLLDIKELTKSFGGLTAVSNVSMHLDDNELVALIGPNGAGKTTLFNLLTGVIVPSEGTISMQTDAGLQVLNKMKPYKVAQTGLARTFQNIRLFKDLSVLDNVLIAMTAKNNEGFFESIFRLPSFYRKEAALRQEAIELLKIFQMENQIDNLAKNLPYGAQRRLEIVRALATKPKILFLDEPAAGMNPEETADLTRLIRKIQKEFHITVLLIEHDMSLVMNVAERVYVLEYGKLIAEGTPDEIQKNERVIKSYLGGES
>NZ_AP014680.1|WP_041092689.1|501070_501781_+|ABC-transporter-ATP-binding-protein
MMLLQVEDLSVNYGVIRAVKGVSFEVNEGEIVSLIGANGAGKTTILKTISGLMKPSGGKIIYNGHEIQKQKSQKIVAGGISQVPEGRRIFSGLTVLENLQMGAFLRKDRDALKADYREVFERFPVLEERKNQDAATLSGGEQQMLAMGRALMAKPKLLLMDEPSMGLAPIFINEIFDIIQAIKQQGTTVLLIEQNASKALAIADRGYVLATGNILMTGTGTQLLGNKDVQKAYLGG
>NZ_AP014680.1|WP_041092691.1|501786_502407_+|CBS-domain-containing-protein
MSVADYMTQDLVTVRPTTRINDAVDLMKKNDIHRLPVLDSGRLVGLITEGIIQSALPSKATSLSVFEANYLLNKTTVADVMEKDVQTISPDAVLEDAIYAMRKYNIGVLPVVNGAELVGIITNNDIFDAFLNISGYGRGGTNVTVYVEKDELGFIAKLGETLASHKYNILTLMVTKRVHDQAIEIHVDSEDTVGVKNALTAAGFKV
>NZ_AP014680.1|WP_041092693.1|502787_504215_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MDTSTNKQETAQAAVPVSHPLLAMSGILVGAFVGMLSETALNIALPSLMTQLHVGIGTIQWLVTGYLLVIGIVLPLSSLLARWFTTRQLIIFALIDFIVGATISALAPDFAVLLVGRMIQGIATGLLLPLMFTVATLIYPPYKLGTAMGMIGLVVMFAPAIGPTLAGIILGVLSWQWIFWAFVPFLLIALVISIKFLPNVVEITKPKVDILSIILSTLGFGGAVVAVSLASDNGWLSPVVLITLVAALLILFFYIRRQLHSQTPILNFHVFSLSHFSIGALLIVIDFGMIISSMYLLPMFWQKGLAVPVALTGIVMLPGGIVNALVSAIAGRFIDQLGPRKLLIPGFLISIIGILMLIFTSTNSPMWYVIMAHVIVMIGAPLGMAPAQTYGLNALDQSTTSDGSTIMNTFQQISGAVATAVATSLLGLGQHASTAATTSRTAFTNGVHTGLMFTLALAVIGFALSFTVKNDKHTA
>NZ_AP014680.1|WP_041092695.1|504428_504983_+|cysteine-hydrolase
MSANEALLIIDYTNDFVATDGALTCGYPGQKIAGEIIRLADEMLKSGGWVILPTDVHTPNDPYHPESKLFPPHNVRNTWGREFYGPLDQWFKKNKNNAQVYMYDKTRYSSFAGTDLDLRLRERGIDSLYLTGVCTDICVLHTAVDAYNLNYQMTIHKDAVAALTDEGQQWALGHFEHVLGAKIK
>NZ_AP014680.1|WP_041092697.1|505148_505643_+|hypothetical-protein
MKFYMYLPRDKKEFILFMAIVSLISVNIIAPLITSFEIGFGWQTWKNVLSILPMIWIAVIAMVLLTYQPASWLTGKIVEEQDGFNAHIIVNILCTVMMMSVILTVVGTWIGQQQVSLESISHFFYRWPRNFAISLGVEMLIAQPIARQILFILHSHQETEKTTN
>NZ_AP014680.1|WP_041092698.1|506247_506772_-|lipoprotein
MKKIFLLLLTASAVIVLTGCSSQSNNKSDSSSNSSSAKSNSSSSSSSATTKTVQLDAEDSTRLLTNSWKFDQFSIDQIKAEAEDGVLELEINWKNASDHATVFDDIGKVTVSQNGKELSITEQDDDYNDSILPNKTEDFELSYRYTGVDNPIKVSIHPTDTSRPTRTVTVQLKN

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Crispr_ID: NZ_AP014680_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP014680_3

652228-652323

Unclear

Consensus_repeat	Method
CGTGTTTTTTCAACCAGTCTTCTAGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP014680_3

>merge|NZ_AP014680|3|652228-652323|CRISPRCasFinder
CGTGTTTTTTCAACCAGTCTTCTAGGGCTAAGTGTACTATTGGCTGAGTTAGCGCTTTGTTGCTGAAACGTGTTTTTTCAACCAGCCTTCTAGGGC

>NZ_AP014680|3|3|652228-652323|CRISPRCasFinder
CGTGTTTTTTCAACCAGTCTTCTAGGGC	TAAGTGTACTATTGGCTGAGTTAGCGCTTTGTTGCTGAAA
CGTGTTTTTTCAACCAGCCTTCTAGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP014680.1\|WP_041092981.1\|662494_662857_-\|DUF4828-domain-containing-protein	unknown	unknown	gnl\|CDD\|374370
NZ_AP014680.1\|WP_041092942.1\|643750_644773_+\|diacylglycerol-kinase	unknown	unknown	gnl\|CDD\|237282
NZ_AP014680.1\|WP_041092940.1\|642300_643728_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NZ_AP014680.1\|WP_052467262.1\|661666_662446_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119381
NZ_AP014680.1\|WP_041092962.1\|652430_653906_+\|UbiD-family-decarboxylase	unknown	unknown	gnl\|CDD\|376697
NZ_AP014680.1\|WP_041092958.1\|650598_651132_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379534
NZ_AP014680.1\|WP_041092965.1\|654488_654947_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014680.1\|WP_041092043.1\|648310_649723_-\|IS5-like-element-ISLho2-family-transposase	unknown	unknown	gnl\|CDD\|377531
NZ_AP014680.1\|WP_041092977.1\|658731_660273_-\|gluconokinase	unknown	unknown	gnl\|CDD\|130381
NZ_AP014680.1\|WP_041092946.1\|646677_646974_+\|type-II-toxin-antitoxin-system-MqsR-family-toxin	unknown	unknown	gnl\|CDD\|374053
NZ_AP014680.1\|WP_041092979.1\|660528_661365_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_AP014680.1\|WP_041092939.1\|640831_642301_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NZ_AP014680.1\|WP_041092975.1\|656656_658012_-\|gluconate-permease	unknown	unknown	gnl\|CDD\|129873
NZ_AP014680.1\|WP_041092960.1\|651235_652117_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_AP014680.1\|WP_041092963.1\|653920_654517_+\|UbiX-family-flavin-prenyltransferase	unknown	unknown	gnl\|CDD\|223241
NZ_AP014680.1\|WP_041092973.1\|655102_656599_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179427
NZ_AP014680.1\|WP_082232280.1\|649835_650471_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|180448
NZ_AP014680.1\|WP_041092948.1\|646987_647917_+\|DUF4065-domain-containing-protein	unknown	unknown	gnl\|CDD\|274805
NZ_AP014680.1\|WP_041092944.1\|645112_646477_+\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|225174
NZ_AP014680.1\|WP_041092983.1\|663014_664016_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745

Protein	Function_ID	Function_description	E-value
NZ_AP014680.1\|WP_041092981.1\|662494_662857_-\|DUF4828-domain-containing-protein	gnl\|CDD\|374370	pfam16110, DUF4828, Domain of unknown function (DUF4828). This family consists of uncharacterized proteins around 120 residues in length and is mainly found in various Enterococcus and Lactobacillus species. The function of this family is unknown.	2.49328e-35
NZ_AP014680.1\|WP_041092942.1\|643750_644773_+\|diacylglycerol-kinase	gnl\|CDD\|237282	PRK13055, PRK13055, putative lipid kinase; Reviewed.	0
NZ_AP014680.1\|WP_041092940.1\|642300_643728_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NZ_AP014680.1\|WP_052467262.1\|661666_662446_+\|hypothetical-protein	gnl\|CDD\|119381	cd06419, GH25_muramidase_2, Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.	5.60514e-64
NZ_AP014680.1\|WP_041092962.1\|652430_653906_+\|UbiD-family-decarboxylase	gnl\|CDD\|376697	pfam01977, UbiD, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. This family has been characterized as 3-octaprenyl-4- hydroxybenzoate carboxy-lyase enzymes. This enzyme catalyzes the third reaction in ubiquinone biosynthesis. For optimal activity the carboxy-lase was shown to require Mn2+.	4.74119e-121
NZ_AP014680.1\|WP_041092958.1\|650598_651132_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379534	pfam14278, TetR_C_8, Transcriptional regulator C-terminal region. This domain is a tetracycline repressor, domain 2, or C-terminus.	5.31139e-09
NZ_AP014680.1\|WP_041092043.1\|648310_649723_-\|IS5-like-element-ISLho2-family-transposase	gnl\|CDD\|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.01879e-12
NZ_AP014680.1\|WP_041092977.1\|658731_660273_-\|gluconokinase	gnl\|CDD\|130381	TIGR01314, gntK_FGGY, gluconate kinase, FGGY type. Gluconate is derived from glucose in two steps. This model describes one form of gluconate kinase, belonging to the FGGY family of carbohydrate kinases. Gluconate kinase phosphoryates gluconate for entry into the Entner-Douderoff pathway. [Energy metabolism, Sugars].	0
NZ_AP014680.1\|WP_041092946.1\|646677_646974_+\|type-II-toxin-antitoxin-system-MqsR-family-toxin	gnl\|CDD\|374053	pfam15723, MqsR_toxin, Motility quorum-sensing regulator, toxin of MqsA. MqsR_toxin is a family of bacterial toxins that act as an mRNA interferase. MqsR is the gene most highly upregulated in E. coli persister cells and it plays an essential role in biofilm regulation and cell signalling. It forms part of a bacterial toxin-antitoxin TA system, and as expected for a TA system, the expression of the MqsR toxin leads to growth arrest, while co-expression with its antitoxin, MqsA, rescues the growth arrest phenotype. In addition, MqsR associates with MqsA to form a tight, non-toxic complex and both MqsA alone and the MqsR:MqsA2:MqsR complex bind and regulate the mqsR promoter. The structure of MqsR shows that is is a member of the RelE/YoeB family of bacterial RNases that are structurally and functionally characterized bacterial toxins.y characterized bacterial toxins.	2.01773e-07
NZ_AP014680.1\|WP_041092979.1\|660528_661365_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	8.51927e-69
NZ_AP014680.1\|WP_041092939.1\|640831_642301_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NZ_AP014680.1\|WP_041092975.1\|656656_658012_-\|gluconate-permease	gnl\|CDD\|129873	TIGR00791, Gluconate_permease, gluconate transporter. This family includes known gluconate transporters of E. coli and Bacillus species as well as an idonate transporter from E. coli. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	1.93092e-159
NZ_AP014680.1\|WP_041092960.1\|651235_652117_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.59675e-40
NZ_AP014680.1\|WP_041092963.1\|653920_654517_+\|UbiX-family-flavin-prenyltransferase	gnl\|CDD\|223241	COG0163, UbiX family flavin prenyltransferase [Coenzyme transport and metabolism].	4.92836e-100
NZ_AP014680.1\|WP_041092973.1\|655102_656599_+\|hypothetical-protein	gnl\|CDD\|179427	PRK02471, PRK02471, bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB.	4.12302e-116
NZ_AP014680.1\|WP_082232280.1\|649835_650471_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|180448	PRK06182, PRK06182, short chain dehydrogenase; Validated.	2.79653e-85
NZ_AP014680.1\|WP_041092948.1\|646987_647917_+\|DUF4065-domain-containing-protein	gnl\|CDD\|274805	TIGR03830, transcriptional_regulator_XRE_family, putative zinc finger/helix-turn-helix protein, YgiT family. This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation.	2.25445e-21
NZ_AP014680.1\|WP_041092944.1\|645112_646477_+\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	8.3777e-176
NZ_AP014680.1\|WP_041092983.1\|663014_664016_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	7.7267e-42

>NZ_AP014680.1|WP_041092960.1|651235_652117_+|LysR-family-transcriptional-regulator
MDTRKLATFVDLAQTKNYSKTAERIFSNQATVSKHILALEKAWNVQLFSRAHRTVTLTHAGETILPAVLELLEKEQQLNRVIKNQSSKEIKELVIKGIPSISQYQAFNVITDFAKQYPDVNLKFSEAETDTLLDTLDDGNADIVFTRLFGNKQLHHDMLINDQDYFVALMPKIHPLAGYKKLTMELLKNESFLLLDSSTNLFKPIISLLKEAGIEPRITYEGRRIDLILGMLDQGMGVSIMMNKSFDLTDYQNIVAIPIEPKQYSRLAFIRRHGKHSATSELFWKFAQKHEGK
>NZ_AP014680.1|WP_041092958.1|650598_651132_+|TetR/AcrR-family-transcriptional-regulator
MANQSRTNEIYLLGALERLLKKKSFDEISITELAKVAGISRMTFYRHYQNITDVLTSEMTAMIDELTTKLNITTVVRHEELVFSMQFLKDHGDFIKILVLAQQQDLLRDNIAQVLARLSANKKQLQDLNSREFDYYVRYHSTGLTGVIVDWITKKQPETPEELATFLERIGEGTQHS
>NZ_AP014680.1|WP_082232280.1|649835_650471_-|SDR-family-NAD(P)-dependent-oxidoreductase
MTKTKVIAITGASSGMGKAALQLFAQRGWIVYGGARRVENIPTGTNIHPIKLDITDSESNHHFINTLLTEQQHIDVLINNAGYGEGGPVEEIPLEKVRKQFETNFFGAVELTKLILPKMRSQNVGRIVNISSIGGDLYMPLNAYYHASKAALQQWSDALDTEVQQFGIRSVIVQPGGTQSSWSKITMDNVRKNLKPDSAYLPFVNSGWYLI
>NZ_AP014680.1|WP_041092043.1|648310_649723_-|IS5-like-element-ISLho2-family-transposase
MVYRKKTVQLSINSFETALGCPLSADNEWVQLANQLPWSEWDEVYQLAFPSNLGRAGKPFRQLYGAQLIKQRTGLSDREVVDAIRDTPAYQYFLGFSEYQPVRPFDHVTLVYFRKRIAPISDQILNIMAKYTGKLLNEALPDKRVVITDATAFPVNVAYPQDTHLLNGTRLKLEADIKLMSNQLKLAPPRTRKREAKKQWVAFSRHPHRWGKQTHKQIKAQLQYIRRDLRFVDELLAQGGQLSERRLKVLSTVRKVYEQQDYMYRNHTHHVSDRIVSLTQPEIRPIVRGKAKQPVEFGPKVDLSITDGVVNIERFSFDSFNESTDFASTIDHYKDVHGVYPDEVLADTLYRTRANIKLCKDLGIKLSGPKLGRRPKHVDPAKRREEQDAENRRGEIEREFSLIKSKLGLGLVTAKTAETIAVTVDTGVVLANLKRVLSFFCVPISIFVEMDGVKLQIDYKMINRLSNLVA
>NZ_AP014680.1|WP_041092948.1|646987_647917_+|DUF4065-domain-containing-protein
MRNTYIKNYTNTFMIHDHEYEVTAPARFDSDTDELIDDNELDDQAVEIANQMYRDDKGLISPNEIKKYRAKIGLSQREFAKLLGWSPNTVALYETGAFPSESNNKLLKALMKDDHFLKTLVENDIDKLPEIVVKKVNDYLDKNNDDVIMATAGAPKFTAVQLTNWYRVTNYFQAQEDENIEELTQMKVVKLLYFAFGRYAAKTHGKLFASRILAMPYGPVVEDVHKEFNGHKGIVSIGLDDVAFDDFSKIQADTEISSLLANILNDYGEKTAAGLSRITHHPGSPWSLTGQGVINPTLIAETFARNVEQ
>NZ_AP014680.1|WP_041092946.1|646677_646974_+|type-II-toxin-antitoxin-system-MqsR-family-toxin
MNNSEALAKLKYLTAKNQFVLVNRRLSRAQAITSSLAKEIVKQLTIADFQKYEADRDRLNEFVWIYETDYGAVYYIKFKFINDNTMVRFISFHVSNYS
>NZ_AP014680.1|WP_041092944.1|645112_646477_+|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MKLNTPVHKNESLEGTVMDLTYQGMGVVKVDNFPVFIPNALPGEEISYGVTKVTKNFAFGRVVDWKKKSEDRVEVKNQQFTQTGIAPLQHLAYPAQLKFKQHQISELLQKTHLDIEVLPTLGMEKPYHYRNKAQVPARMIHGKVETGFYKRGSHQLVPIEDFFIQDPKIDAAIIVVRDLLRKFHIEPYNEETNKGVIKTVMVRRGYYSHEMMIVLVTKTKKLPMVQELIDGMTSQLPEVVSIVQNVNSAKTNVLLGDKNFTIYGKPTIDDQLMGINFTISPNSFYQVNPQQTEKLYQRAIEQAELTGNETVIDAYCGIGTISLAVAQHAAEVYGVEIVEDAVEDAKHNAKRNKIANAHFVVGKAEEQMAKWQEDGLEPDVIMVDPPRKGLAPEFIEAAAEMQPKKVVYVSCNPATLVRDIELFATQGYTVKQPIQPVDQFPQTTHIESITVLSR
>NZ_AP014680.1|WP_041092942.1|643750_644773_+|diacylglycerol-kinase
MRERARIIYNPTSGREALKNDLVDILAIYEQAGYETSAFATTAEPNSARDEANRAAKEKFDLIIAAGGDGTINEVVNGIAGLRHRPKMAIIPAGTTNDYARALRIPREDPIGAAKTILKKQSIMMDIGKAGENYFINIAGGGLLTELTYDVPSGVKSLFGYLAYIVKGAELLPQIKPIQMDIKYDGGEFKGKASMFLLALTNSVGGFEQIVPDASLDDGKFTMIIVKTSNIVELMRLMTLVLNGGKHVEDPRIIYRKTSKLVAKPVDDRMMINLDGEYGGDAPMTFENLARHIEMVANLDAIPDDAVTGISPEVRRAEDRFVKEVQKLPDNQTPSDDDEK
>NZ_AP014680.1|WP_041092940.1|642300_643728_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MNFETTIGLEVHVELKTNSKIFSPSPVQFGSKPNANTNVIDWGYPGVLPSTNKGVVESGIKAALALHADIEHHPHFDRKNYFYPDNPKAYQISQSETPLAHDGWIEIEVDGETKKIGIAEMHIEEDAGKNTHSPNGYSFVDLNRQGTPLIEIVSKPEIASPDEAYAYLEALRQRIQFTGVSDVKMEEGSMRVDVNISIRPIGSDKYGTKTELKNLNSFNYVRKGLAFEEQRQQRVLMSGGTIGQETRRYDETSGQTILMRVKEGSDDYRYFPEPDLPVLEISDDWINGIKAQLPEMPSARRDRYVNKLGLKEYDAMVLTQTKEMSDFFEATIGKGADAKMAANYLMGDINAYLNDNHVDLQDTKLTPDNLAGMINLINDGTISTKMAKKVFKAITNGEEPAAYVKENGLVQLSDPAQLQPIIDEVLSNNEQSIEDFKNGKDRAVGYLVGQIMKQTHGQANPQVVNQLLMKALKAK
>NZ_AP014680.1|WP_041092939.1|640831_642301_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MDFYDTDLTSLHEDLVNKKISSTELTKATYENIAADDDQVKAFLTLNQEQALKKAAEVDKQGVAVDQLVSGIPLGVKDNIVTKDLKTTAASKILSNFTPVYDAAVIEKLKAQNFIDAGKLNLDEFAMGGSTENSAFQTTHNPWDLTRVPGGSSGGSAAAVAAGEILAAMGTDTGGSIRLPASYNGVVGMKPTYGRVSRWGIIAFGSSLDQVGWLTRSVKDNALLTSLISGHDDRDLTSSTKEVPNFAGQLNDDTNVKGLRIAVPKEYLGEGVDDNVKVVIQAALKHYESLGAIIDEVSLPNTQYGVAAYYIISSSEASSNLQRFDGIRYGVRATDVENLEDVYVRSRSEGFGDEVKRRIMLGTFSLSAGFYDAYFMKASQIRTLIRQDFEKVFEDHDLVMGPAGPTVAYKIGSNITDPKAMYMNDVLTVPVNMAGLPGMSIPAGFADNMPVGLQIIGKPFDEETMYKAAYTFEQSTDFHKQTPKLGGQN
>NZ_AP014680.1|WP_041092962.1|652430_653906_+|UbiD-family-decarboxylase
MTEQPYDLRKVLAEIKDDPMQYHETNREIDPNADLAGVYRYIGAGGTVKRPTTEGPTMMFNNVKGFPGSRVLIGLQASRKRVGKILHHDYKTLGQMLNEAVSNPVKPVEVKREDAPAQEVVHLASDSNFDIRKLLAAPTNTPEDAGPYITMGVVYGHSVDGKQSDVTIHRMVLEDKDTIGMYIMPGGRHIGAFLKDYEQQNKPMPITINIGLDPAVTIGATFEPPTTPLGYNELQVAGALRNEPVQVVPGVAVNALGIARSEWIIEAEIQPNQTMQEDINTNTGYAMPEFPGYNGTANPAVNVVKIKAVTHRKDNPIVQTTIGPSEEHVSMAGIPTEASILSLVDRAIPGKVLNVYNAPAGGGKLMTIMQIHKDNEADEGIQRQAALLAFSAFKELKTVILVDEDVDIFDWNDVMWTINTRFQADRDIMVLEGMRNHPLDPSELPEYDPARIRVKGMSSKLVLDGTFPYDMRDKFKRAEFKEIPDWKKYLD
>NZ_AP014680.1|WP_041092963.1|653920_654517_+|UbiX-family-flavin-prenyltransferase
MKKVVVGITGASGTIYGIRLLEVLHAMPNVETHLVMSQWAKENLAVEDTGYTETQVKALADLTYSEQNMGAKIASGSFIHDGMVIIPASMKTVASIATGVGENLIARAADVTLKEQRQLIIVPRESPFNQIHLENMLKLSKMGVGIIPPIPAFYNNPKTVDDIINHSVMKILDHLQIENSVSTRWEGLAHARKDAQNK
>NZ_AP014680.1|WP_041092965.1|654488_654947_+|hypothetical-protein
MPAKMPKTNNEIPNTFKVDVTKSGYTMVAILERQNQDVLIQLIGGDVPHYGVVMSIDNTGNTETIRLPSRPGHVHQEKILIEQVAGAIKPVLQNNAIIVSGMHVNDISTEQMHAAIPMAQKLGARLAVWLKQNPVDPLPMSFAKKNSVNNRV
>NZ_AP014680.1|WP_041092973.1|655102_656599_+|hypothetical-protein
MPKRLREQIKQPESISKLFQGLFGIELEEHRILTDGRLSRYPYPSEYASRKTHPYLQSDFTDSMLELVTEPTKGGLQAVKNLKILQQISQEHLKKDERIWPFSMPPKLVDDDLEFAHGNFSRTWYQEYRDYLESKYGIEHEIICGVHVNYSLNEDLIYNLYRSGFDKKYDTPAAFKNAIYFKMAQSFVLNRWFFTYLFGASPLSENKYQKLPADLTMPVRSLRSSSLGYSNTNKEAITYESLTAQVEQMERYVADGTFYSIDEFYGPVRLKGKSDDLREILDQGVDYLEFRAFDLDPLSRAGVSDDTLDLMELFLTYSLVADEPDDMYDSLQIALARNEEVALSDPKQQPKWLPEAAKNVIDKLTKFAHEFEAPKRYLMAVEIANKRVNDVGLTIGSQLASKIEDQSLATYGLKLANDHYAKWLNEQRPLVAIDKEYSKTAQSIIKAAIIMGIHVQLHHGFKLTVGKHHEWFEAQTKIELPHGVESYLKVIFPELTTE
>NZ_AP014680.1|WP_041092975.1|656656_658012_-|gluconate-permease
MELLVLLLGIILLLFLIIKFKLNTFVALIITSVVVALGLGMDPAKIAESIQTGIGGSLGELSLVFGFGAMLGRLVADAGGAYKIATTLINKFGRKWLQAAVMIASFIIGIALFFEVGMVLLIPIVAAIAIEAGVPILYLGISMAAALSVTHGFLPPHPAPVAISAALHANTGKVLVYGIIVALPSAIIAGPVFTKLAQKFAPSAFEQKGNLSSFGEIKKFTDDEAPSFGMSVLTSLFPVILMAITTIYQLVFTNGSFPKNPNGMDNFIAFIGSPSIAMLISLVFAMWSMGVLQKRKVTDIMQSLEDAIKSIAMLLLVIGGGAAFKQVLIDGGVGNEVAKLFIHSSISPLILGWLIAVVLRIALGSATVAALTAAGLVMPLMTQAGVDPALMVLSIGAGSLAASHVNDAGFWMFREYFDLTVKQTLSIWTVLETIISVVGLLMVLLLNLIFN
>NZ_AP014680.1|WP_041092977.1|658731_660273_-|gluconokinase
MDYMIGVDLGTTSTKAVLYDDQCNVLGYANKLYPLYQDQPDMAEEDPNEIFDAVVDALTEVLRKADLTTGTLRGVSFSAAMHSLIGLDKDHNPITRVITWADNRAAKYADEYKKNGIGFELYKKTGTPTHPMSPLYKLIWLKNEHKDIYDNAAYWIGIKEYIFYRLFGVLKEEYSIASATGLFNIFNLDWDEQALELTGVSRDQLPELVDPFEQVSGMHAEYAKVIGIPTDTPFIMGASDGTLSNLGVNAIDPGVVAVTIGTSGAVRVVTDKPTIDPKGRVFCYALTKDKWVVGGPVNNGGIVFRWVRDQLFAPEKITADMMNIDSYDMLTQIASEVPAGSDGLLFHPFLGGERAPIWDANARGSFFGLTRKHTRAHMVRAALEGIVYNLYTVMLALEEVVGKPKEIMATGGFARSELWRQMLADIFESPVTIPKSFESGALAAVVMGMKSLGTIDDLSDIKNFIGETNTYQPNPENYEVYRELVPIYIRLSRQLQTEYANIAAFQRKHGSTK
>NZ_AP014680.1|WP_041092979.1|660528_661365_+|MurR/RpiR-family-transcriptional-regulator
MVEDSLVSIKAYYNGFSDNEKKIASYVVKHAAIIQELTISDLAKKCQTSTASISRFVKHIGYLNYREFLMEMPKSTYGDVFSEIEEDDSDTQITEKTFNGAINALKATKKMLDKNKVKQAAKFLQHTNKLSFFGLGGSSIVALDGFHKFIRTSLECEYHPDFDIQLMQAVKLTKDDCAIVVSHSGRNQQTMLVAKELKKRHVPIIAITSYPTSELAQIADVALIAVAEEVNFRSESMSSLMAQLTIMDSLFMMTAIYHTDKTENILRDVRGIMQKTRA
>NZ_AP014680.1|WP_052467262.1|661666_662446_+|hypothetical-protein
MAKRKIEPIYDNTFRRSNRHNYKKHPWIILVIVLLVLGGAGGLIWHNHHQSALNSYAVRGVSVNQADGYVDFHQLQSQKIKFAYLKATSGASYLDDDFIDNYQRISGSNLQVGIYQQFSFTSSAKSQFRYLVSQVQQQSGNLPIAIQVTYYGKYADTPPNAKKQGQKLAELAELLSEHYGQGCIIWATPAVQRDIVDSYLPQNKKWSVPTKLKRQGKDVMFIQYTGHQKLEVDGVRTDLTQSVFNGSLKQWNEQFGSNE
>NZ_AP014680.1|WP_041092981.1|662494_662857_-|DUF4828-domain-containing-protein
MKRHNILLFGAGLIAGLSSTLGLGRSKSAHTTSLPIFYAGTWEYYDPERNRTHQLEITPDLKLSIDNHDITTTVELIDDHHLIYIDKFGYHITIQANEQRPVKLIDDADDQTYTITVPEQ
>NZ_AP014680.1|WP_041092983.1|663014_664016_+|Gfo/Idh/MocA-family-oxidoreductase
MLKLGIIGTNWITDQFIEAANVTKRWQLTTVFSRTTQRAQEYSSKFHAQEFFTDINEFFSNGVFDAVYIASPNSLHYQYARQAIENDKHVIVEKPAFTNPDEFSQIEALLQAHPKVRLVEAARHVHTPLFAQVKQQVNDMDQVQGATLTYMKYSSRYDQVLAGKTPNVFSLEFAGGALQDLGVYPVYSAVALFGEPNSVVYFPTLIATKADGKGVAILRYDDFEVTLNFGKTSNSHLVSEIYGLKDTLVMDNPADLTDAVYYDADQQAHKLSAPVEANDMVPELRDFAALLEQPNDKEQLKKYQEWFDLSRQVNSLLDTLRQSAGIEFPSDNR

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Crispr_ID: NZ_AP014680_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP014680_4

672138-672276

Unclear

Consensus_repeat	Method
GTCGAATTTTGACCATCATGAACGTTATTTTGTTGTTACACGTAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP014680_4

>merge|NZ_AP014680|4|672138-672276|CRISPRCasFinder
GTCGAATTTTGACCATCATGAACGTTATTTTGTTGTTACACGTAGCCATCTGCGGTTGAGAACACATTTTAACAATTAAAAATAAGAAGCGTTAGTCGAACTTTGACCATCATGAACGTTATTTTGTTGTTACACGTAG

>NZ_AP014680|4|4|672138-672276|CRISPRCasFinder
GTCGAATTTTGACCATCATGAACGTTATTTTGTTGTTACACGTAG	CCATCTGCGGTTGAGAACACATTTTAACAATTAAAAATAAGAAGCGTTA
GTCGAACTTTGACCATCATGAACGTTATTTTGTTGTTACACGTAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP014680.1\|WP_041093003.1\|673702_673909_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014680.1\|WP_041092994.1\|669429_669834_-\|GtrA-family-protein	unknown	unknown	gnl\|CDD\|377229
NZ_AP014680.1\|WP_041092987.1\|665597_665990_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl\|CDD\|374224
NZ_AP014680.1\|WP_052467265.1\|672501_673398_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NZ_AP014680.1\|WP_052467264.1\|669040_669331_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_AP014680.1\|WP_041095187.1\|666027_666216_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|377942
NZ_AP014680.1\|WP_041092991.1\|667361_668486_+\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	unknown	unknown	gnl\|CDD\|223458
NZ_AP014680.1\|WP_052467267.1\|676724_678914_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379207
NZ_AP014680.1\|WP_052467268.1\|679090_680857_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119382
NZ_AP014680.1\|WP_041093009.1\|681767_683528_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|287142
NZ_AP014680.1\|WP_041095198.1\|683718_684651_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133030
NZ_AP014680.1\|WP_041092997.1\|670554_671073_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014680.1\|WP_041092996.1\|669846_670302_-\|flavodoxin	unknown	unknown	gnl\|CDD\|180922
NZ_AP014680.1\|WP_041092989.1\|666683_667055_-\|DUF805-domain-containing-protein	unknown	unknown	gnl\|CDD\|377540
NZ_AP014680.1\|WP_041093005.1\|674073_674868_+\|recombination-regulator-RecX	unknown	unknown	gnl\|CDD\|237619
NZ_AP014680.1\|WP_041092999.1\|671286_672072_+\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
NZ_AP014680.1\|WP_041093001.1\|673432_673675_-\|DUF2922-domain-containing-protein	unknown	unknown	gnl\|CDD\|378571
NZ_AP014680.1\|WP_052467266.1\|674981_676460_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NZ_AP014680.1\|WP_041093007.1\|680999_681332_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370635
NZ_AP014680.1\|WP_052467263.1\|668682_669048_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|377579

Protein	Function_ID	Function_description	E-value
NZ_AP014680.1\|WP_041093007.1\|680999_681332_-\|hypothetical-protein	gnl\|CDD\|370635	pfam09726, Macoilin, Macoilin family. The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.	0.00135044
NZ_AP014680.1\|WP_041092994.1\|669429_669834_-\|GtrA-family-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	6.18799e-15
NZ_AP014680.1\|WP_041092987.1\|665597_665990_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	gnl\|CDD\|374224	pfam15919, HicB_lk_antitox, HicB_like antitoxin of bacterial toxin-antitoxin system. This is a family of HicB-like antitoxins.	2.48965e-10
NZ_AP014680.1\|WP_052467265.1\|672501_673398_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	3.30605e-50
NZ_AP014680.1\|WP_052467264.1\|669040_669331_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.4746e-09
NZ_AP014680.1\|WP_041095187.1\|666027_666216_-\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	2.22071e-15
NZ_AP014680.1\|WP_041092991.1\|667361_668486_+\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	gnl\|CDD\|223458	COG0381, WecB, UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane].	5.61937e-162
NZ_AP014680.1\|WP_052467267.1\|676724_678914_+\|hypothetical-protein	gnl\|CDD\|379207	pfam13472, Lipase_GDSL_2, GDSL-like Lipase/Acylhydrolase family. This family of presumed lipases and related enzymes are similar to pfam00657.	4.22205e-12
NZ_AP014680.1\|WP_052467268.1\|679090_680857_+\|hypothetical-protein	gnl\|CDD\|119382	cd06522, GH25_AtlA-like, AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml autolysins from Streptococcus mutans which have a C-terminal glycosyl hydrolase family 25 (GH25) catalytic domain as well as six tandem N-terminal repeats of the GBS (group B Streptococcus) Bsp-like peptidoglycan-binding domain. Other members of this family have one or more C-terminal peptidoglycan-binding domain(s) (SH3 or LysM) in addition to the GH25 domain.	9.27772e-63
NZ_AP014680.1\|WP_041093009.1\|681767_683528_+\|hypothetical-protein	gnl\|CDD\|287142	pfam10131, PTPS_related, 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein. This domain is found in various bacterial hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. The exact function of the domain has not, as yet, been established.	7.5496e-07
NZ_AP014680.1\|WP_041095198.1\|683718_684651_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133030	cd04187, DPM1_like_bac, Bacterial DPM1_like enzymes are related to eukaryotic DPM1. A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.	7.00354e-73
NZ_AP014680.1\|WP_041092996.1\|669846_670302_-\|flavodoxin	gnl\|CDD\|180922	PRK07308, PRK07308, flavodoxin; Validated.	1.20272e-47
NZ_AP014680.1\|WP_041092989.1\|666683_667055_-\|DUF805-domain-containing-protein	gnl\|CDD\|377540	pfam05656, DUF805, Protein of unknown function (DUF805). This family consists of several bacterial proteins of unknown function.	1.1062e-19
NZ_AP014680.1\|WP_041093005.1\|674073_674868_+\|recombination-regulator-RecX	gnl\|CDD\|237619	PRK14135, recX, recombination regulator RecX; Provisional.	2.35626e-96
NZ_AP014680.1\|WP_041092999.1\|671286_672072_+\|type-I-methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	8.1493e-127
NZ_AP014680.1\|WP_041093001.1\|673432_673675_-\|DUF2922-domain-containing-protein	gnl\|CDD\|378571	pfam11148, DUF2922, Protein of unknown function (DUF2922). This bacterial family of proteins has no known function.	1.8413e-14
NZ_AP014680.1\|WP_052467266.1\|674981_676460_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	1.91229e-17
NZ_AP014680.1\|WP_052467263.1\|668682_669048_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|377579	pfam05973, Gp49, Phage derived protein Gp49-like (DUF891). This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.	8.93009e-15

>NZ_AP014680.1|WP_041092999.1|671286_672072_+|type-I-methionyl-aminopeptidase
MISLKSPREIEAMKKSGAVLAGMHIGLRDIIKPGISSWEIEEFGRHYIESHGGVAEQIGFEGYKYATCVSINDEICHGFPRKGLILKNGDLVKVDTVVSLDGAFSDSCWSYAVGEASPEVKKLMDVTHKALYLGIDQCVIGNRIGDIGSVIQDYVENQNGYGDVREFIGHGIGPTMHEEPNVPHYGEAGHGIRLREGMTITVEPMVNVGTWKADTSDPNGWLAKTADGSLSCQYEHTLAITKKGPQILTSQDPGFDAKYLF
>NZ_AP014680.1|WP_041092997.1|670554_671073_-|hypothetical-protein
MKKIMGFTTLFALTLALTGCASVNTKSSENSSSSQISSAQVTKTPSTSSSLSTSNATVKSSSSSTATEPSYSKNSSSVIYEPAKNMMQNDPSDSYNNKVNNDSSSSAMYESGKNMMQNDPHDSYNNKVNNDPHAGNSSSSAIYESGKNMMQNNPNDSYNNKVNNNPNACGMN
>NZ_AP014680.1|WP_041092996.1|669846_670302_-|flavodoxin
MASALVVFATITGNNEDVADIVTEAFEDLNVDVEEVEITQADPSDFENVDICVVCPYTYDEGALPEEGLDFYEDLQEMDLAGKVYGVAGSGDTFYLDDFNVAVDKFAAAFDKSGATRGAEPVKIDLEPDTDDIKTLTTFVEALVAKANNAD
>NZ_AP014680.1|WP_041092994.1|669429_669834_-|GtrA-family-protein
MLLALFKKYQSMIAYIFFGGVTTLVNIGVFAVLDKMNWNYQLANVIAWFLSVLVAYLTNKVWVFSSHYTTFKAFIIEFVEFYFFRALTLIIDVIIMYIGISMLGWNAILVKVIDNVIVIIVNYVFSKWYIFKKV
>NZ_AP014680.1|WP_052467264.1|669040_669331_+|helix-turn-helix-transcriptional-regulator
MIKAKTHDEFLDLLKSEDPELEYSIKVQERRADLSVQLMDLRKQRGMSQRKLAGKSGVAQSTIAHIERGDVDATSKTLDLLMIALNSKYRTQLSLN
>NZ_AP014680.1|WP_052467263.1|668682_669048_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MLKYVYYQSDRGDQPVMEFIYGLPLRDRKKLILTMVMIQKLGIHRSLKNQFVKKIRGKNIFEIRSRLGNNIQRILYFTVDGELLVLTNRFTKKTQKTPIDQIKLAEKRRRVFLESWRDQND
>NZ_AP014680.1|WP_041092991.1|667361_668486_+|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)
MSVPRKIMTIFGTRPGAIKMAPIITAMRSMPDQFEPVVVVTAQHRQLLDQVLNFFAIEPDFDLNTMQPRDSLSERTSKMLHHLDNVINAAQPDMILVVGDASTTLAAGLAAFYHKIPVGHVEAGLRTYDKYAPFPEEMNRHLTDVLSDLYFAPTTLSRDNLIAENHSVDNVFITGNTSIDALKYTVRADYHHPTLDAIPANHRILLMTMQRRENLGTPMKRVFHAIRDVVETNPDVELIYPVHPNPDVMAIADDLLGGRERIHLVEPLDLLDFHNFAARSYLILTDSGGIQEEAPALDKPVLVLRTKTERPEGVTAGTVRLVGTFPEEIQRAAFELLHDSKEYKKMAHAPNPFGDGNAATRILKVIKDYFNNEQ
>NZ_AP014680.1|WP_041092989.1|666683_667055_-|DUF805-domain-containing-protein
MIDSYKKFWNNILNFSGTSNRPDYWWPAIINWILGGIIIAILQGIMGHPLTQIYTWHDLGIASIRNIVVLIVWLATLSVSVRRLHDTDRSGWWVFIQIIPLIGGIWFFILMILPTKYNRWQNK
>NZ_AP014680.1|WP_041095187.1|666027_666216_-|type-II-toxin-antitoxin-system-HicA-family-toxin
MPMKTRDFEKLLKQHGFKALRQAGSHKTYYNPDTHKQLVVPIHSREIPKGILNKMMKQAGLR
>NZ_AP014680.1|WP_041092987.1|665597_665990_-|type-II-toxin-antitoxin-system-HicB-family-antitoxin
MKNINLVTYPALLTPDENNTFDIEFVDVPEALSFGNSINDAVVHGQEALGLALYGRKTLPEATIIDDIQKNDNQTIVIVSVDLNIVKSQVKEVTIRKNVTVPADLAEQAQAQGINFSATLSDALREKLGV
>NZ_AP014680.1|WP_052467265.1|672501_673398_+|YihY/virulence-factor-BrkB-family-protein
MRQSAFNKVSIFFKMFFRHYGMAEVSSSAIVLAYYSLLSIFPAVIMIGNILPLVGLSADTVLNYLSTAIPSTVYNFIKPLISDFLRNGSGGLLSIGAVVTLWSTSQAVAAFQRSVNRAYGVAQDQNAIVNRIVSFVWMVVVVAIMAVIIVFFSIGQLILEQLQPIIHIDMSLIRFIASIKWPVTFLVLFIALSLLYYFVPNARIKFRYVLAGSLLSTFLWMMLSQVFSIYTHLFARTVTSYKTVGVFIVLMIWLDLSGMIVMIGATLNATVQELLEGKIDEKARPLEHVISRIKRHNK
>NZ_AP014680.1|WP_041093001.1|673432_673675_-|DUF2922-domain-containing-protein
MKSLNLTFKGSLGKAHTLKLGYANDNLDAKTVKNTMDQLAALDLFVANGEKIYAQPVSAKYVETTTTPVYTATEEPVPAV
>NZ_AP014680.1|WP_041093003.1|673702_673909_-|hypothetical-protein
MIRTFTNAKVQLMMVGEDHEKGIARTFSHLPEDAKDEQIQTLGSLLETISADKFDNAIVTVSHQLDPK
>NZ_AP014680.1|WP_041093005.1|674073_674868_+|recombination-regulator-RecX
MTKKITKIGMQKRPGRYNIFLDEKYAFSVSESVLINFRLAKDMEIDGQLEKLILADDDVAKAYSKALNYLAHQLRAESEVITKLKELELDDNVIDEVMQKLREQNLIDDQNYADSYVRTIMLTSDKGPSVIRQNLRQKKIGENLIDQALQQYPEDALLENGTKLAEKQLKHYHHFPVKVRLQKVRQSMMIKGFKGDLITQILNNITIKEDPDEEWENMKAQAQKLWQRNRKYAFRERILRTKRSLFGKGYSTEFINRWIEEQKI
>NZ_AP014680.1|WP_052467266.1|674981_676460_+|C40-family-peptidase
MKANIGKRKDITLKAWSFAGFVLAAVSIGLTTPLSVHAATTDTTENSSIEVDAASGASSSASANSVNSSSAVAQPAVSNSASASEVSGVAANSSSVAGSTSSVASSQSDTTTVDNSAVATTNSAASDAKQVKTDSATIIPTTGYSADSSGDAVYYSNGELANGYINDGNNWYLFKDGVKQSDVQAWAGTYYYFDHTTYLRSDNVYAKSNWGDYYLFGNDGRIATDVQAWAGTYYYFDHSTYLRVDNNYAKSNWGDYYLFGNDGKIATDVQAWAGTYYYFDHHTYLRVDNKYVRSNWGDWYMFGANGRIVSGFANWLNRTYYFNASTYLKVINSYVKNGNNTYWLDDTGVMRTQTWQIEKAIEVGMALVGKSPYDWGGGRTSASIANKSFDCSSFIHYIFAAVGINLGNYTSATTYTEIKLGTAVSWSDMKRGDIFFMDNCGHVGIYLGNGLFLHDSPNSSTGGVGINSLSDMNKEMGKTWAQIADGSVRRII
>NZ_AP014680.1|WP_052467267.1|676724_678914_+|hypothetical-protein
MNNDIKVRFKMYKKGCQWLTCILTLAGVTMFSVATGNADTMDQANDSNNIGVQKNINSSSVNLENAGSDSANYVSSAPTQTKAATVNNTSTALADSTDKASSPAVANDQNKSQDDFTQDNYVAMGDSITQGWDGQETVATPYPEKVSQILSFNSVNGSSYAIGGAHIDGNASSDFTQRVNDLITDPELNSYDIVSIDYGINDLNYGNNSLIDIQNAMIDGINKIISANGNIKIYGILPIASYKLGGQDNIGAGGFSENDLLNAEAEVYQSFRIPYLDWRSDPIVTNDNYKQMLGTDVRDYTHPTQSTYNIIAQRVADFFKNNLPSTLTEHKSTLVPSAKFTGLVHESSTDSWYYYNDTGSKVIGFELINSSGYTEFNAKNGSANFVSANMNGEMYFNTITGQGIKNQLININNGLYYFDNNGYAVSGLQTIDGNQYYFNNQTYQAATNTIITVNGKNLFFDNNGQHQSGGYYVKNGNAYYLDPNTGQNVKNKYLQTPVGWLMFGKDNNGAAVSGVYQWAGSYYYFDSKTHLKVTNSIEQASWGDWYGFGNDGRILTGVNKIGNTYYDFNAKTYTMIVNNYAKSQWGSWYLFGSDGKILTGVQRWAGSYYYFDPVTYLKRTNAYLKAQWGSWYLFGSDGRILTGVQKWAGTYYYFDSQTFLKVTNAYVRSQWGSWYLFANDGKIVSGWTDWMGSTYYFDQQTYLKFTGVHVINGQTYNFDKNGMLDKTSK
>NZ_AP014680.1|WP_052467268.1|679090_680857_+|hypothetical-protein
MATSVSADVNDGSQTSASTVSADNTISSSSAVTLSSSSSENSGVGTVDSSSSSNITNANNSDTDVANSSSATTGTNMVSSVSDVKSSSNSVATSDLGNVSDEQASTAKAYAASAYAASGADQVITRVDATATVDNGWTTESGVQYYYQNGQKANGYINDGSNWYLFKDGVRQSDVQEWAGTYYYFDHNTYLRVDNAYMKSNWGDYYLFGSDGRVATDVQKWAGTYYYFDHNTFLRVDNAYMKSNWGSYYLFGPNGSIQTEVQKWAGTYYYFDRYTYLRRTNAYLKSQWGDYYLFGSDGRIATDVQKWAGTYYYFDHHTYLRVDNKYVKSNWGNWYLFKSDGRIASGWYTYGYSSYYFNPNTYLLEKVVSSKASGEVDGWTIGDPMRPQVAAVDISSYQSGLTQANYNTLKSLGVKTVIVKLTEGTTYNNPYAANQIKQAEAAGLNVAVYDYAKFNSMSTAASEANYMVAYLEKYGISKSTTIIADMEDTSTYSSTVAQDLNQFWSTLNVSGYTAHVVYTYVSYKYRDAVVSTVGQNNTWIAQYPYSPLVNTTWNSSYGAWQVSSQAYIPGYSGNVDVSVDYNGLLANM
>NZ_AP014680.1|WP_041093007.1|680999_681332_-|hypothetical-protein
MKKILLLLTTGILLLTVTACSNASNSNKGSNNYSNKASKKVSSSSVTSSYSNSLSNNNSISTAVNSSSASSKKQSSSVTNSTSSSSQNMMQNSPSDSYNNKVNNNPNADK
>NZ_AP014680.1|WP_041093009.1|681767_683528_+|hypothetical-protein
MKKMNSFLQQKNIDVVIVLAAVSIIIMLPQIYEHAIIVSGDSLFHLNRFYETYKQIKTGNYSYFQTLYGFNGSARIVNALYGPYLAYLMGFFLLILKSWFKFQLVTGFLLLFISGYSMYFLARKISIKKAIAVGLAIMYMCTPWVASESFTAVGAALFPLVFVAGASMVNVPKPVSILKLSLLMSVLIEVHVFTSVLAVVVLIPFFVVGMIKNENKGKLLLHTILSALITFCLTSNVWIALVEVMGSNKVLTVFPSEMTRSTMGFSDVQFSLLSYGIIYSVVFMFVLVRTIVMWRKIGFFEKLIDLIGIFFLLISTGLFPWRVVEHRFVFLRTFVQFPQRFSVVAFVAIILGLGIFLNDYPALKSIQLKNIGKIFYLVLLSLLIINANSMFKVVTQSWNTSSPYAATTLPLTKDANKIRESFKNSNNLGEPFEYLAKVNPDYLPTQKNFTGTVDAYSKLNPYNLYYQQISLNKVKLKHRVERKGTIEVSWINSGLDSRFMQLPLVEYAHSSIYINGHKATKRNSKVSKIGVISVYSDVGKNTLTIEYIPSQTTRKILIANWICWMFFLLVIGLSFLRKKLFLDRID
>NZ_AP014680.1|WP_041095198.1|683718_684651_+|glycosyltransferase-family-2-protein
MKRLSIIVPCFNEEDTIPIFFKVIEKIVKSMKNINTEYWFIDDGSSDHTLTAIHKLNADYPDVVHFISFSRNFGKESALYAGLKAATGDYVVVMDVDLQDPPELLPKMYDYLASGEFDCVGTRRTNRDGEPPIRSFFADQFYRLINSISSTNIVNGARDYRMMTRQMVDAIMSMTEYNRFSKGIFSWVGFKTKFIEYHNVERVAGNTSWSFWKLFKYSIDGIMDFSDMPLSIASWTGILSFITALLGLVFIIVRAITVPNSSVSGWASLVCIMLLIGGLQLLCLGIVGKYIGKIYLQSKNRPIYIVKEKK

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Crispr_ID: NZ_AP014680_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP014680_5

886816-886898

Orphan

Consensus_repeat	Method
GCCATTGCGGTTCCAGTTGCACTGTTAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP014680_5

>merge|NZ_AP014680|5|886816-886898|CRISPRCasFinder
GCCATTGCGGTTCCAGTTGCACTGTTAGGTCATATGAGTCCTCAAGGGGCGATCGCCATTGCGGTTCCAGTTGCATTGTTAGG

>NZ_AP014680|5|5|886816-886898|CRISPRCasFinder
GCCATTGCGGTTCCAGTTGCACTGTTAGG	TCATATGAGTCCTCAAGGGGCGATC
GCCATTGCGGTTCCAGTTGCATTGTTAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP014680.1\|WP_041093252.1\|875781_877134_+\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|181493
NZ_AP014680.1\|WP_041093262.1\|885750_886392_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_AP014680.1\|WP_041093258.1\|884019_884760_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|226674
NZ_AP014680.1\|WP_041093248.1\|872590_873304_+\|acetolactate-decarboxylase	unknown	unknown	gnl\|CDD\|341211
NZ_AP014680.1\|WP_041093246.1\|870815_872495_+\|acetolactate-synthase-AlsS	unknown	unknown	gnl\|CDD\|236312
NZ_AP014680.1\|WP_041093277.1\|897200_897545_+\|YlbF-family-regulator	unknown	unknown	gnl\|CDD\|237467
NZ_AP014680.1\|WP_041093269.1\|888759_889242_+\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|377139
NZ_AP014680.1\|WP_041093250.1\|874164_875688_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_AP014680.1\|WP_041093279.1\|897619_898864_+\|DNA-repair-exonuclease	unknown	unknown	gnl\|CDD\|277319
NZ_AP014680.1\|WP_041093266.1\|887360_888257_+\|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID	unknown	unknown	gnl\|CDD\|377079
NZ_AP014680.1\|WP_156406614.1\|878040_878145_+\|holin	unknown	unknown	unknown
NZ_AP014680.1\|WP_041093267.1\|888284_888704_+\|PTS-fructose-subfamily-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|225446
NZ_AP014680.1\|WP_041093256.1\|883269_884010_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|226674
NZ_AP014680.1\|WP_041093274.1\|895077_896091_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_AP014680.1\|WP_082232304.1\|880253_882980_-\|HAD-IC-family-P-type-ATPase	unknown	unknown	gnl\|CDD\|319775
NZ_AP014680.1\|WP_052467289.1\|889383_890031_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014680.1\|WP_041093272.1\|892792_894919_+\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|273955
NZ_AP014680.1\|WP_041093271.1\|890159_892673_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|223256
NZ_AP014680.1\|WP_041093260.1\|884824_885712_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_AP014680.1\|WP_041093275.1\|896206_897124_+\|ribokinase	unknown	unknown	gnl\|CDD\|238579

Protein	Function_ID	Function_description	E-value
NZ_AP014680.1\|WP_041093252.1\|875781_877134_+\|aspartate-aminotransferase-family-protein	gnl\|CDD\|181493	PRK08593, PRK08593, aspartate aminotransferase family protein.	0
NZ_AP014680.1\|WP_041093262.1\|885750_886392_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	8.15214e-40
NZ_AP014680.1\|WP_041093258.1\|884019_884760_+\|SDR-family-oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	4.88709e-76
NZ_AP014680.1\|WP_041093248.1\|872590_873304_+\|acetolactate-decarboxylase	gnl\|CDD\|341211	cd17299, acetolactate_decarboxylase, alpha-acetolactate decarboxylase. alpha-acetolactate decarboxylase (AldB, E.C. 4.1.1.5) converts acetolactate ((2S)-2-hydroxy-2-methyl-3-oxobutanoate) into acetoin ((3R)-3-hydroxybutan-2-one) and CO(2). Acetoin may be secreted by the cells, perhaps in order to control the internal pH. AldB may function as a regulator in valine and leucine biosynthesis and in catalyzing the second step of the 2,3-butanediol pathway. The structure of this domain displays an alpha-beta-beta-alpha four layer topology, with an HxHxxxxxxxxxxH motif (x could be any residue) that coordinates a zinc ion.	9.28625e-106
NZ_AP014680.1\|WP_041093246.1\|870815_872495_+\|acetolactate-synthase-AlsS	gnl\|CDD\|236312	PRK08617, PRK08617, acetolactate synthase AlsS.	0
NZ_AP014680.1\|WP_041093277.1\|897200_897545_+\|YlbF-family-regulator	gnl\|CDD\|237467	PRK13676, PRK13676, YlbF/YmcA family competence regulator.	3.99689e-33
NZ_AP014680.1\|WP_041093269.1\|888759_889242_+\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|377139	pfam03830, PTSIIB_sorb, PTS system sorbose subfamily IIB component.	2.28373e-52
NZ_AP014680.1\|WP_041093250.1\|874164_875688_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	1.07893e-86
NZ_AP014680.1\|WP_041093279.1\|897619_898864_+\|DNA-repair-exonuclease	gnl\|CDD\|277319	cd00840, MPP_Mre11_N, Mre11 nuclease, N-terminal metallophosphatase domain. Mre11 (also known as SbcD in Escherichia coli) is a subunit of the MRX protein complex. This complex includes: Mre11, Rad50, and Xrs2/Nbs1, and plays a vital role in several nuclear processes including DNA double-strand break repair, telomere length maintenance, cell cycle checkpoint control, and meiotic recombination, in eukaryotes. During double-strand break repair, the MRX complex is required to hold the two ends of a broken chromosome together. In vitro studies show that Mre11 has 3'-5' exonuclease activity on dsDNA templates and endonuclease activity on dsDNA and ssDNA templates. In addition to the N-terminal phosphatase domain, the eukaryotic MRE11 members of this family have a C-terminal DNA binding domain (not included in this alignment model). MRE11-like proteins are found in prokaryotes and archaea was well as in eukaryotes. Mre11 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.64032e-46
NZ_AP014680.1\|WP_041093266.1\|887360_888257_+\|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID	gnl\|CDD\|377079	pfam03613, EIID-AGA, PTS system mannose/fructose/sorbose family IID component.	7.70102e-98
NZ_AP014680.1\|WP_041093260.1\|884824_885712_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.74951e-27
NZ_AP014680.1\|WP_041093267.1\|888284_888704_+\|PTS-fructose-subfamily-transporter-subunit-IIA	gnl\|CDD\|225446	COG2893, ManX, Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism].	5.38451e-32
NZ_AP014680.1\|WP_041093256.1\|883269_884010_+\|SDR-family-oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	1.13629e-75
NZ_AP014680.1\|WP_041093274.1\|895077_896091_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	4.99779e-100
NZ_AP014680.1\|WP_082232304.1\|880253_882980_-\|HAD-IC-family-P-type-ATPase	gnl\|CDD\|319775	cd02080, P-type_ATPase_cation, P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase. This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_AP014680.1\|WP_041093272.1\|892792_894919_+\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_AP014680.1\|WP_041093271.1\|890159_892673_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|223256	COG0178, UvrA, Excinuclease ATPase subunit [DNA replication, recombination, and repair].	0
NZ_AP014680.1\|WP_041093275.1\|896206_897124_+\|ribokinase	gnl\|CDD\|238579	cd01174, ribokinase, Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.	4.48835e-135

>NZ_AP014680.1|WP_041093262.1|885750_886392_-|histidine-phosphatase-family-protein
MANLTVYVIRHGETLLNSFNRMQGWCDSDLTKKGRQDAIKTGQTLSSVHFDYAYSSDLNRAIDTKNLILQQLDQVPPVSKVNSDFREVLFGYFEGLDSDATWKQVGQPAGYNTQEEIIADKGLIEARRLMHLADPSNLAETYAQVIKRWQAGLNQLRKDAHDNANILLVTHGTFIRTLADYHHINTLDNYPKNGGISILKLSDNDSQLITYNE
>NZ_AP014680.1|WP_041093260.1|884824_885712_-|LysR-family-transcriptional-regulator
MNPELLQTFLKIVEYKQISQAADSLYITQAAVSNRLRRLESQLGVTLINRLKGQPTVTLTRYGEKLVPIAEQWMQLVHQTTNLKESANFHNIKVASAPSISESILSIICPLLMKEDPTLRYSLINGNADYIYSCVESGTADIGFTFYKMYRHQINTRKISEEHLMLVTNNLSEYPDMVTVDMLSRHDEIYMPWNDEFDAWHTMCWDSELQPLVVLDAGTLILPYLSFKQAWSLIPESLAHQLLLRDSNLRSLRLVEQPPALPVVAVKRKVPGTEQKELERLEFKIRSELYKIHQQ
>NZ_AP014680.1|WP_041093258.1|884019_884760_+|SDR-family-oxidoreductase
MEIKNQVVVITGASTGIGRATALALSKLGAKVVLGARRASKLESLVAEIKQNGGDAVYQITDVTDFSQVKKLIDVAVTQFGRVDVLFNNAGVIPVGSLSDLSVMSTEHLVDVNIKGVLYGIKAVLPVMHQQGSGHIITTGSNASHVITPEFATYASTKFAVRAIMDGLRQEEIGNHIRATLIAPGTVNTNLYESISDPVKQQQSKEFVAAHGMNPAVIANAVIYALEQPDNIGVNEVLIRDVEQAD
>NZ_AP014680.1|WP_041093256.1|883269_884010_+|SDR-family-oxidoreductase
MHVKDQIVVITGASSGIGKATAIKLAKLGAKVMLGARRATELQSIVAQIEKNGGVAQYRVTDVTKFEDVRQLVNAAKKVFGRVDVLYCNAGVMPVATIDSLSIDEINAMVDINIKGVLHGIKAVLPTFHEQGSGHLIATASNSAHVINSRFAVYAATKFAVRAIMDGLRQEEIGNHIRSTIISPGAVNTNLYKTSSDPTTRAELQQVERDRGINPDTIADAVVYAMTQPDNIGVNEVLLREIQQDD
>NZ_AP014680.1|WP_082232304.1|880253_882980_-|HAD-IC-family-P-type-ATPase
MIDDDPHIQTNNQQWWQMSSAEIADTLKTDPEEGLSRAEAQERLTKNGRNELTAKKKSNFIRFIKQFNNSIIYILAVAAIVTFLMHHYSDSIVIALVIIANAIIGYVQERQADDALAKISELLISKNFVIRGDEKLELDSRELVVGDLVNLEAGDAIPADLRLISADNFSVQESSLTGESVSVEKTDEPLTNGDLAITSQTNMAFASTLVTTGSALGIVTATAIDTEIGHIQQSVSEVKEQPTPLMRNLNKLGFGLSVAILIAAAILFIIGWLTQVYSLPILLIVIVTMVVGSMPEGLPASTSVVLAMGTQQMTKKNVIVKTLPAVETLGAVDIVNTDKTGTLTKNEMTVTVATTADRVYEISGVGYDAEGNLDLDGQLQYNGKTVDWHSDDNMRWLINIAGQTTDAQLHHEDGVWEITGEPTDGALTTLFKKLTGEYPDSEPIDSLPFDSAIRYSARLVDFEGQRVLMLKGSPATIINMAVENGMPIDEQYWEDQMAKMTAQGLRVVALAYQPVATDIEDIDPISIGQDMIIAGMVGMIDPPREEVAQSIIQLRQAGIKVKMITGDHPDTAKAIAATLGLDERINAITGPEIDEMSPEQLQDHIDEYNVFARTTPKNKLQIVNAQRANGHVVSMTGDGVNDAPALKQADIGVAMGIKGTEVAKESANMVLANDKFTDIVAAVREGRHVFDNINKTIRFLLPTSFAEGLVVAFSILLGQEMPLYPTQLLWINMVSALTIQFAFIFEPPESGIMMRGPRSVKSGILSKMDIVEIVYVSVLISGLGIWAFDWVTGLGVPTVVASTMTLNIIIFGKIFYLFNIRNSYPVISKYFFQNKMAFYIIGVLILLQMGIIYLPFMHGIFHTTSVNFFFGWLIPIIAGVIVLVITEIIKLARIAYRKESGKKAEQFN
>NZ_AP014680.1|WP_156406614.1|878040_878145_+|holin
MSIVDAILLMLDFGGLLLMLISVIVGIVVAIIKR
>NZ_AP014680.1|WP_041093252.1|875781_877134_+|aspartate-aminotransferase-family-protein
MDLKTNKAHAMIAEENRHYAKSARINYFDLVIDHAHGAELVDVDGNKYIDLLASASAINVGHTHEKVVQAIQDQAAKLIHYTPAYFHHEPGQQLAKKLAEIAPGDSEKMVTFGNSGSDANDAIIKFARAYTGRSYVVSYMNSYHGSTYGSQTLSGCSLNMTRKIGPMLPNVVHVPFPDAYRTYPNETLHDVSVRYFDEFKRPFETYLPADETAVVLIEPIQGDGGIVKAPDEYLHWVYDFCQEHGILFAVDEVNQGLGRTGKMWSIDNFGIEPDLMSVGKSLASGMPLSAVIGKKEVMESLDAPAHLFTTSGNPVCCAASLATLQVIEDEHLVEKSATDGAYAKQAFKKMQERYAFIGDVRMYGLNGGIEIVMDKQSKTPDADAATKIIYRAFQKGLVIITLQGNILRFQPPLVITRDQLNEALQKLDDIFAELDQGLIELPDDLGNVGW
>NZ_AP014680.1|WP_041093250.1|874164_875688_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MTQIKIVQLEKVVAGQTLFTTASLTANGREIVGVIGNNGTGKTTLMRIIAGMDADFTGQRLIQGQVGLVAQVNPITDRSGGQETVTKIRTMLAQNPEILILDEPTANLDEEHQDWLVGQLRSFRGLILVISHDQHFLTQIATCIWAFENHTVTQFNGSLTAYEQLKTQTNLNQTHEYQRQHRQEHELKLAVQARKEKAAHIRRGSRQMGRVERAKTKSAREQNAGKMEHNAHALLMRAEKQAVVTKPFEQRAIKLMQTDFPIFKGKTVVSADHLDVKNVNKTLLQQVSFQIKPGERVALVGPNGIGKTSLIQAIISHAMHTNLSQHAKIGYFNQDITTLPLDQSVWGFIQRASGLDNERTKTILGAFGLSAPFYPRLIGSLSGGEQVKLQLLSILLGESNFLILDEPTNFLDTQALQALADYLHHYPGTVLLVSHDINFRQQVATRTLLFQNKHLIDPTKTTMHAQKPSELPLLQLKYDRLMATGEGSVQELQELKQQIEQLKQHAL
>NZ_AP014680.1|WP_041093248.1|872590_873304_+|acetolactate-decarboxylase
MRDTITLYQHGTLAMLVAGLFEGTLPLGELLEHGDTGIGTADSLDGEMVIVDGQAYKVQGSGKVVPLTPDTKVPFASVHFMDAQETRSLVGVTDEQLKEQLQAEMKMDNVFVGVRIDGTFSHMHTRAVNKQVRPFPNLTAATRVQPEFEQDQVSGSVVGYFSPHLFQGATVGGFHWHFINTTRDFGGHILDFTVNQAEISVQVLENMVQHLPITNTEFRAKNMALDSLNKDIDEAEH
>NZ_AP014680.1|WP_041093246.1|870815_872495_+|acetolactate-synthase-AlsS
MADEQRYGADALVESLINHQVKYVFGIPGAKIDRLFELLDHPKDPNSPQLIVTRHEQNAGFLASGIGRLTGQPGVVATTSGPGASNLATPVVTATAEGDPIVAISGQVPLKDLFRQTHQSMANKELFAPITKFSAEIGDPENISEVVANAFQSATEGKQGASFISLPQDVDDAKVTTKALPPLSAPKLGPASGESLAELVRRIKTAKLPVLLVGMRASSPDVTAAIRKLVKKAGIPVVETFQGAGIISHELEQDYFFGRVGLFRNQPGDKLLKHADLVITVGYDAIEYEPRNWNAEQDAVITVIDTTAPQLDKNFQPTTELIGDIAATVSDLADQVENYQPADESKQYLQDLHTEIEADQHETIPAGKGNLNHPLAVIEALQQRVDDKMTVSVDVGSHYIWMARHFRSYEPRHLLFSNGMQTLGVALPWSISAALVRPNAKSVSVSGDAGFLFTGQELETAVRLGLNTVHLIWNDGYYDMVRFQEIMKYGKDAAVKFGPVDYVKYAQSFGATGLRVESPDQLGAVLDQAFATDGPVVVDIPIDYSHNAELGETMLADQF
>NZ_AP014680.1|WP_041093266.1|887360_888257_+|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID
MSENPTVEASNDEPQATTEHRIPQPDAITNKDLMKSWFGWWWANEIPHTFDRMLAPSFCFGLIPTLQKLYKDKDELAKAFQRHLLFFNTQATWGGGTLTGVTISLEEARAKALANGEEPISEDMINNTKVGLMGPLAGIGDSIDSGTVQYIFIAMFLPFAKQGNFLGALLPFLCFAIATFTYGYYFTKMGYSLGRSAAKEIMTGGRMQGIIDGLGILGLYMMGILAGQYITVRSYLKFSISGKVFNVNSILNEILPGALPLLAVMLVYWYFQRQGLKITRALLYLTGALIVLGIFYII
>NZ_AP014680.1|WP_041093267.1|888284_888704_+|PTS-fructose-subfamily-transporter-subunit-IIA
MKRAFLVITHGDMGTETVKSMELLMGPQENVTALGLHPGESVDSLRDQAYEVLAKNEDQYEETIVLVDLLGGSPSNVSLSTLAKYRELKIVTGLSLPLLINLLNFSEAEADTEKLINDSIDVAKDGMKLIDKNFLQHKS
>NZ_AP014680.1|WP_041093269.1|888759_889242_+|PTS-sugar-transporter-subunit-IIB
MGIINLARVDDRLIHGQVMTKWTKGFGTNSVYVVDNATAADDFMKDIYVSTNSTGGLSIKVYSATEVAEEWKKNQFGDDKVVIVFKYIKEVQEALDAGLELKSLNIGGVSKKPNTEFVIPTVAIGDEERALLKAIHDSGIDVFFQTVPDSRKVEYNSAIK
>NZ_AP014680.1|WP_052467289.1|889383_890031_+|hypothetical-protein
MKNNYEVYPDKIRTYTTSIIFLAFALGFLAIIFVKTWLILKLFAIFFGVLFAYLAYKTFRDGHLDHPDYLINDQGVTDNTKDSPVTVSWDDILKIEMTPNNAVMQIGILATSTVSDEAQKATALKDNLSNNGNLAFYSIMIDGFRYRQKPFLKIFKELERQGIEHNPQILISEYIDLETKRKMADKRDAEIRAARKQRKLEQRMNNPKKHWWQRS
>NZ_AP014680.1|WP_041093271.1|890159_892673_+|excinuclease-ABC-subunit-UvrA
MAVQHRETIPENIEVTGAHVNNLKNIDVKIPLNAFVAITGRSGSGKSSLAMGVLYAEGARRYLDALSTYTRRRISQVGKAAVDQVKHLPSALALRQRPTVPGVRSTVGTMTESLNVLRLMFSRLGSHRCPNGHQIPPTLEVAENMGYVTCPVCHVTFMAFGAEDFAFNSQGACPDCNGTGKIRQIMPERLIPDQTLTLRQGAVASWRLPGRNFMIYVAQQIGIPIDTPFNQLSAAQQKQVWSGKKEQYAINIPSKTGKIFHMDNAQYENAFAAVEDSLATTTNERAIQRLNRFYDFTTCPTCHGNRFDPKLMTTKLADLNIAQVSQMTMTELMDFADKILDWLPDKMQPIGKNLVGEFSNSLQPILDLGLDYLTLDRPGETLSTGELQRIQLGRTLRSETTGVLYILDEPSIGLHPANVAGLIKILRQLVSMGNSLVVVDHDTSIISAADYVIEIGPAAGNDGGTIVAQGTVAEIKRESQSLIAPFLTGTATLRDRPIIANEQPTENKQLQVTVNDRYNLHNVTAKFLLNRLNVVSGYSGAGKSTLILDSLIPALKAANAGSALPKYVKSVATGGIKNIVTVDSVPVGKNVRSTVATYTGILDELRKLFAQTDEAQQAQFNASHFSYNVKAGACPTCNGTGSISLDIQYLPDMVEECPTCHGKRYNDETLQIKWNNMSIADVLALDVNGAIKVFEQTPKIKSMLSQLQSMGLGYLHLGESTPALSGGEAQRLKLVSHMGRKQDETLFVFDEPSVGLHPLDIQTLIKVFDQLLAKGATIITIEHDLDILANADYIIDLGPKGGQLGGQIVGSGTPQELANNQNSETGKFLKQHLQLFQ
>NZ_AP014680.1|WP_041093272.1|892792_894919_+|PBP1A-family-penicillin-binding-protein
MNNQPSGFKRWLAEFKEWLSPLWQQFKQILKRFWHRFQLTRWIIIVFLSLFLLVSGYLTVVAKTAHVSNLKATLEKPTMVYDKDNDSAGSLYSQKGTYVSLAKISTNVQNSVLSTEDRDFYHEHGFSVKGIGRAAFLYAKNKVLHRDYISGGGSTLTQQLVKNAYLTQQQTFTRKAKEIFLSIEVENVYSKSDILAMYLNNAYFGNGVWGVQDAAQRYFNCSASELTVPQSAVLAGMLTSPSGYDPVAHPKASKQRRNVVLQLMVENGKLSQSQATSYKKTALTITNGYKQTDTYKYPYYFDAVINEAINKYNLSEEDIMNKGYKIYTTLDQNQQQDMQTVFKNDNNFPADSTDGTQVQAASVAINPNNGGVTAVVGGRGTHVFRGFNRATQMKRQPGSAIKPIAVYTPALENGYYYDSILQDKKQSYGTNNYTPKNYDDTYSGKVPAYKALAQSLNAPTVWLLNKIGVNKGYESVKKFGLPVTNKDKNLALALGGLSTGVSPQQLAGAYTAFANDGKLTTPHYITKIVDASGKTIVNNDNPKKKQIISKKVAKQMTSMMLGVFNDGTGRTAKPTGYSVAGKTGSTSSDVVNGQDSERDKWIVGYTPDVVVATWEGYDTTDVDHTLSDTSYVNTNTLFKTEMTQILPNTKQTEFNTKDAATLAKNKDDSATSVWDEVQNGASQFGDKVSQGASSFGQKAADWWSNLTN
>NZ_AP014680.1|WP_041093274.1|895077_896091_+|LacI-family-DNA-binding-transcriptional-regulator
MSKKTTIRDLAQAAGVSVTTVSQILNGKGQRFSSETQQHVLKLQQQLNYVPDFNARNLIMKSSQSIGVLVPNIGNPFFSTFIKGVQTTARELKYIPLIFGANHDEKIESYYLEKMIERATGGMIIASASITTETIDSTLKKNEIPYLLMDQNPIVDGDRVQTNDILGGQLAAEHLIKLGHQKFVITMPNAPTANLLRRVEGFKLALTKNSISFEHAATIVYSPMTKAGGYQATKAVLASHATAVFAINDEMAIGLYKGMRQQNINVPTDISIIGYDNIDLDEYITPTLTTIQQPILEMGITATRLLVNRIKQPLIAPQVTELPVHLVERNSTAKPRS
>NZ_AP014680.1|WP_041093275.1|896206_897124_+|ribokinase
MTNKVTVLGSLNLDTTLRIKRMPQPGETLMTENKSSAAGGKGANQAVAASRAGAQTSFIGQVGKDSAGQFMVESLQDDNINTDGIAVDETVGTGSAFILLDEDGQNSILVYGGSNKHVSKQEVDAATKQIKESDFLISQFETPQEAALEAFKLAKENNVVTILNPAPASKIMPELLQVTDLIVPNETESASLTGIEITDEASMVASAKAFQQMGVKNLIITVGSKGAFYATAGEHDFVPAFKVKAVDTTAAGDTFIGALSSQLKSDLSNIASSLVFAQRASSITVQRLGAMPSIPTVAEIKAASK
>NZ_AP014680.1|WP_041093277.1|897200_897545_+|YlbF-family-regulator
MAVNIYDSANQMERDLRETQEFTALKEAYEAMKQDAATFKMFRDFQTMQMQLQQKQYQGQQPSEDEIKNAQELAGKVGKVDSIKQLMEKEKAVDQLLSDVNNVITKPIQELYQE
>NZ_AP014680.1|WP_041093279.1|897619_898864_+|DNA-repair-exonuclease
MKFIHTADLHLDSPFLGLQDAPEDLWQSIQQSTFTSFERIVDDALKFKIDFICIAGDIFDRDQRSIAAENFFVRQCSRLQDANIDVYLSYGNHDYQMVTDETKVLPANVHVFGNQVETKTLKLADKTTVAISGFSYGSRWIDDDQTSEYPIKANVDWQIGMLHGALTGLKNPHDNYAPFTVQELLDKNYDYWALGHIHKRQILHRNPIIAYCGNAQGRHRNEAGPKGYYLVTEENQQLVPEFHETAPIDWQTISLELEETDSAAELVTSLQRQVELQVNDTKLTLVSIQLTGSEKLTDELIVQLDNGSILARLQSQIKDTATLKFWPYEAKIRVSVDQPSFTSLDQHYWDEAAQTVFTHENITQLAEKLFQHSFIADQFSQPQTLTDLQQAVTMALQTTQNQEEQQDEDSANSN

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Crispr_ID: NZ_AP014680_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP014680_6

918535-918678

Orphan

Consensus_repeat	Method
AAAATAACAATCAATAAATCAAGGAACGCTTTATCAATCGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP014680_6

>merge|NZ_AP014680|6|918535-918678|CRISPRCasFinder
AAAATAACAATCAATAAATCAAGGAACGCTTTATCAATCGTTATTTCTTCTTGCTATTTAGATAACATGTGTTCGCAGATACAGATGTCTAGGACTAAGTTTAAAACAACAATCAATAAATCAAGGAACGCTTTATCAATCGTT

>NZ_AP014680|6|6|918535-918678|CRISPRCasFinder
AAAATAACAATCAATAAATCAAGGAACGCTTTATCAATCGTT	ATTTCTTCTTGCTATTTAGATAACATGTGTTCGCAGATACAGATGTCTAGGACTAAGTTT
AAAACAACAATCAATAAATCAAGGAACGCTTTATCAATCGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP014680.1\|WP_041093311.1\|921899_922211_+\|ribosome-assembly-RNA-binding-protein-YhbY	unknown	unknown	gnl\|CDD\|376702
NZ_AP014680.1\|WP_041093304.1\|919490_919688_+\|50S-ribosomal-protein-L35	unknown	unknown	gnl\|CDD\|234676
NZ_AP014680.1\|WP_041093315.1\|922851_923460_+\|bis(5'-nucleosyl)-tetraphosphatase-(symmetrical)-YqeK	unknown	unknown	gnl\|CDD\|224627
NZ_AP014680.1\|WP_041093298.1\|914239_915076_+\|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	unknown	unknown	gnl\|CDD\|234899
NZ_AP014680.1\|WP_041095250.1\|918960_919467_+\|translation-initiation-factor-IF-3	unknown	unknown	gnl\|CDD\|234582
NZ_AP014680.1\|WP_041093310.1\|920759_921884_+\|ribosome-biogenesis-GTPase-YqeH	unknown	unknown	gnl\|CDD\|237511
NZ_AP014680.1\|WP_041093291.1\|908203_908839_+\|DUF4479-and-tRNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|239196
NZ_AP014680.1\|WP_041093301.1\|915691_916165_+\|transcriptional-repressor-NrdR	unknown	unknown	gnl\|CDD\|234774
NZ_AP014680.1\|WP_041093317.1\|923459_923816_+\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|272901
NZ_AP014680.1\|WP_041093308.1\|920236_920767_+\|YqeG-family-HAD-IIIA-type-phosphatase	unknown	unknown	gnl\|CDD\|225090
NZ_AP014680.1\|WP_041093319.1\|923812_924553_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_AP014680.1\|WP_041093303.1\|917547_918480_+\|primosomal-protein-DnaI	unknown	unknown	gnl\|CDD\|236353
NZ_AP014680.1\|WP_041093313.1\|922223_922859_+\|nicotinate-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|234611
NZ_AP014680.1\|WP_041093300.1\|915072_915672_+\|dephospho-CoA-kinase	unknown	unknown	gnl\|CDD\|234620
NZ_AP014680.1\|WP_041093292.1\|908872_909262_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014680.1\|WP_041093293.1\|909287_910619_+\|UDP-N-acetylmuramate--L-alanine-ligase	unknown	unknown	gnl\|CDD\|234757
NZ_AP014680.1\|WP_082232418.1\|910782_911421_+\|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl\|CDD\|198414
NZ_AP014680.1\|WP_052467291.1\|916176_917544_+\|DnaD-domain-protein	unknown	unknown	gnl\|CDD\|226138
NZ_AP014680.1\|WP_041093296.1\|911547_914214_+\|DNA-polymerase-I	unknown	unknown	gnl\|CDD\|235591
NZ_AP014680.1\|WP_041093306.1\|919725_920079_+\|50S-ribosomal-protein-L20	unknown	unknown	gnl\|CDD\|179959

Protein	Function_ID	Function_description	E-value
NZ_AP014680.1\|WP_041093311.1\|921899_922211_+\|ribosome-assembly-RNA-binding-protein-YhbY	gnl\|CDD\|376702	pfam01985, CRS1_YhbY, CRS1 / YhbY (CRM) domain. Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly. GFP fused to a single-domain CRM protein from maize localizes to the nucleolus, suggesting that an analogous activity may have been retained in plants. A CRM domain containing protein in plant chloroplasts has been shown to function in group I and II intron splicing. In vitro experiments with an isolated maize CRM domain have shown it to have RNA binding activity. These and other results suggest that the CRM domain evolved in the context of ribosome function prior to the divergence of Archaea and Bacteria, that this function has been maintained in extant prokaryotes, and that the domain was recruited to serve as an RNA binding module during the evolution of plant genomes. YhbY has a fold similar to that of the C-terminal domain of translation initiation factor 3 (IF3C), which binds to 16S rRNA in the 30S ribosome.	1.29208e-31
NZ_AP014680.1\|WP_041093315.1\|922851_923460_+\|bis(5'-nucleosyl)-tetraphosphatase-(symmetrical)-YqeK	gnl\|CDD\|224627	COG1713, COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism].	6.06305e-70
NZ_AP014680.1\|WP_041093298.1\|914239_915076_+\|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	gnl\|CDD\|234899	PRK01103, PRK01103, bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase.	2.57868e-142
NZ_AP014680.1\|WP_041095250.1\|918960_919467_+\|translation-initiation-factor-IF-3	gnl\|CDD\|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	1.90527e-89
NZ_AP014680.1\|WP_041093310.1\|920759_921884_+\|ribosome-biogenesis-GTPase-YqeH	gnl\|CDD\|237511	PRK13796, PRK13796, GTPase YqeH; Provisional.	0
NZ_AP014680.1\|WP_041093291.1\|908203_908839_+\|DUF4479-and-tRNA-binding-domain-containing-protein	gnl\|CDD\|239196	cd02796, tRNA_bind_bactPheRS, tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate the 2'OH of the terminal ribose of tRNA they belong functionally to class 1 aaRSs. This domain has general tRNA binding properties and is believed to direct tRNAphe to the active site of the enzyme.	3.18136e-39
NZ_AP014680.1\|WP_041093301.1\|915691_916165_+\|transcriptional-repressor-NrdR	gnl\|CDD\|234774	PRK00464, nrdR, transcriptional repressor NrdR.	4.28532e-90
NZ_AP014680.1\|WP_041093317.1\|923459_923816_+\|ribosome-silencing-factor	gnl\|CDD\|272901	TIGR00090, rsfS_iojap_ybeB, ribosome silencing factor RsfS/YbeB/iojap. This model describes a widely distributed family of bacterial proteins related to iojap from plants. It includes RsfS(YbeB) from E. coli. The gene iojap is a pattern-striping gene in maize, reflecting a chloroplast development defect in some cells. The conserved function of this protein is to silence ribosomes by binding the ribosomal large subunit and impairing joining with the small subunit in response to nutrient stress. Note that RsfS (starvation) is an author-endorsed change from the published symbol RsfA, which conflicted with previously published gene symbols. [Protein synthesis, Translation factors].	6.4763e-47
NZ_AP014680.1\|WP_041093308.1\|920236_920767_+\|YqeG-family-HAD-IIIA-type-phosphatase	gnl\|CDD\|225090	COG2179, COG2179, Predicted hydrolase of the HAD superfamily [General function prediction only].	1.91569e-71
NZ_AP014680.1\|WP_041093319.1\|923812_924553_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.54295e-14
NZ_AP014680.1\|WP_041093303.1\|917547_918480_+\|primosomal-protein-DnaI	gnl\|CDD\|236353	PRK08939, PRK08939, primosomal protein DnaI; Reviewed.	2.06426e-164
NZ_AP014680.1\|WP_041093313.1\|922223_922859_+\|nicotinate-nucleotide-adenylyltransferase	gnl\|CDD\|234611	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase.	3.65656e-80
NZ_AP014680.1\|WP_041093300.1\|915072_915672_+\|dephospho-CoA-kinase	gnl\|CDD\|234620	PRK00081, coaE, dephospho-CoA kinase; Reviewed.	1.37646e-80
NZ_AP014680.1\|WP_041093304.1\|919490_919688_+\|50S-ribosomal-protein-L35	gnl\|CDD\|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	3.94028e-17
NZ_AP014680.1\|WP_041093293.1\|909287_910619_+\|UDP-N-acetylmuramate--L-alanine-ligase	gnl\|CDD\|234757	PRK00421, murC, UDP-N-acetylmuramate--L-alanine ligase; Provisional.	0
NZ_AP014680.1\|WP_082232418.1\|910782_911421_+\|Bax-inhibitor-1/YccA-family-protein	gnl\|CDD\|198414	cd10432, BI-1-like_bacterial, Bacterial BAX inhibitor (BI)-1/YccA-like proteins. This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.	2.40041e-41
NZ_AP014680.1\|WP_052467291.1\|916176_917544_+\|DnaD-domain-protein	gnl\|CDD\|226138	COG3611, DnaB, Replication initiation/membrane attachment protein [DNA replication, recombination, and repair].	6.81127e-43
NZ_AP014680.1\|WP_041093296.1\|911547_914214_+\|DNA-polymerase-I	gnl\|CDD\|235591	PRK05755, PRK05755, DNA polymerase I; Provisional.	0
NZ_AP014680.1\|WP_041093306.1\|919725_920079_+\|50S-ribosomal-protein-L20	gnl\|CDD\|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	2.95849e-61

>NZ_AP014680.1|WP_041093303.1|917547_918480_+|primosomal-protein-DnaI
MESVSESIKKLMKNRNVDPEYQKLIQRVYADSDVQSFLQENKGKLTENSIQRGEAKLYEFVNEKSKLARNEEIFAPGYQPTLVLSGNLIDISYLPTKELLAKQAQTALKHRVRSISMPKLINSASFDQFDMDNASRNEALMLANEFVADYRNKPDQFHPGLYLYGSFGVGKSYLLGAIANELAKYNVATTLIHFPSFAVEMKNAIGDNNTGDKIESIKKAPILMLDDIGADAMSAWIRDDVLGVILEYRMQAELPTFFSSNFSMVDFEKEHLAVNQRGDVEPLKAKRIMERVRFLAREVTMTGNNRRSKA
>NZ_AP014680.1|WP_052467291.1|916176_917544_+|DnaD-domain-protein
MVDYNSSLSPQTGFLVCLSNRFSTFSADVLVNLYQPILGSQAFGLFYALKSNLSKHPVISNRTAHSHLLTRLNIDVKQLYQARIRLEALGLVRSFETSDQLGDVVVYELQPTLTPQQFIDDDLLSVLLLEAIGEQSFADLVNDSIAYQYDTVSLQAVTKNFFDSYHINQNDVTKLPDTIRESRQKFEVSNANEHGSLIKSDFDFKLLLQLLSSQPIDTKDLTANRQLIENEHLIYGIDEPQMARLIMQATSLTNNQLDKKQLKHLISASYQQVPIKTDEQVKNEPVKTGELKDLTGNEQALINACQSYSPIEFLQTLMVQKNGFVTTGEEYVLRDLINRKLFAPAVVNMLIYYVLQERGQATLTKNLIDTVANSWSQAKLTTPVQALNQIKNYNQKKTTNKRSSGGNYNRRQVKEKLPDWAQDDYQTTTQKATPEQIAKLKAQIEQQRKQQSKEG
>NZ_AP014680.1|WP_041093301.1|915691_916165_+|transcriptional-repressor-NrdR
MHCPHCQHNSSRVIDSRPTEDGRCIRRRRECENCGFRFTTFERCEETTLLVIKKDGTREAFSRQKLLNGIIRSAEKRPISMEKITQVVDEIDNQVRGLGESEVTSQVIGEFVMSALKDLDEIAYIRFASVYRQFKDMDDFMAELQAVMKHDNSRGKG
>NZ_AP014680.1|WP_041093300.1|915072_915672_+|dephospho-CoA-kinase
MTTILGLTGGIATGKSTVSAFFKSKDIPVIDADVVARQVVKIDSAGLRQIIAAFGPRFLNVDHSLNRKQLGELVFTHPDKLTELNEIMQPLIANEVQRQISTFKQLKVPLVVLDAPLLFEQHYENVVDLIMVVTTTPAIQLDRLMKRNQLSQKNAEKRISAQWSLIEKEKRADVVIDNSRSIEATNQQVVEWLEINHLV
>NZ_AP014680.1|WP_041093298.1|914239_915076_+|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase
MPELPEVETVRRGLLKIATDRKITGIDVLYGKTITNDVEFFRQSLIGQTIKTVDRRGKYLLFRFSNHLTMISHLRMEGKYFNLPEGEEPRKHTHVVFHFDDQTKLCYNDTRKFGRMTLVKTGEEMQVAGLKTIGPEPTTDSLTIEYLTEIMSKSRREIKPFLLDQSKVAGLGNIYVDEVLWMSQINPLEPVNHLTSEKISQLRDNIIEELAVATKHHGTTVHSYTTAFGEAGEFQSHLHAYGNAGKPCERCGTTLVKTKVAQRGTTYCPHCQILGVVV
>NZ_AP014680.1|WP_041093296.1|911547_914214_+|DNA-polymerase-I
MTKQLLLIDGNSVAFRAFFALHSQLDKFTNKNGLHTTAIYGFNLMLDHVLKVVKPDAALVAFDAGKTTFRTEMFADYKGGRSKTPPELSEQMPYLKQLVTAYGIKNYELVNYEADDIIGTLAKEASDNGYNTTIVTGDRDLTQLATDQITVSVTHKGVTEVEHYTPEHVLEKFDLTPNQIVDMKGLMGDTSDNYPGVTKVGEKTAIKLLKEYGSVENLYEHVDELKPSKMKEHLIEDHDQALMSKKLARINQSAPLEISLAELTYQGPQTDELVKFYQEMNFQSFLSKMNVEQTELSLDTPVDKAIDYTVLTADNLELVKKLGKSVVFYLEMPDANYHISPFAGFVIGHGDQWLVSRDVELLQQPGLTKLLVSTEIKKNVFNAKAMIVGLNRLGVQLNNVDFDLLLVSYLLNTNDNSDDLGLVAHEHGYEDIEADEIIYGKGVKRAIPDDDEKLFTHLAKKARAIDLLATQLFDELEENEQTPLYTDIELPLTNVLAQMEIMGIKVDTDRLSAMGSQLIERLSEIEQTIYQEAGQEFNIKSTKQLGEILFEQMKLPVIKKTKTGYSTAVDVLEKLRDQAPIVDNILKYRQIAKLQSTYIEGLLKVVHSSDQKIHTRYLQTLTQTGRLSSVDPNLQNIPIRLEEGRKIRQSFVPSHPDWEIFSSDYSQIELRVLAHVTGDENLQEAFLEDQDIHASTARRIFKLGPDAKIDRNLRRQAKAVNFGIVYGISDYGLSQNIGITRKQAKTFIDTYFEEYPGVKKYINNVVKEAKKTGYVETLTHRRRYLPDINADNFNKRSFAERTAMNTPIQGSAADIIKIAMIGMQTALKENGLKAKMLLQIHDELVFEAPKEEIPILEKLVPSVMDSAVKLDVPLKVESAHGATWYDAK
>NZ_AP014680.1|WP_082232418.1|910782_911421_+|Bax-inhibitor-1/YccA-family-protein
MYGNMALAVLMSALSSFLTLTVFKEQVFNYMSQHSGMMWIILLIPVGLSLGISFRATRNPVASFIMLMAVSIIYGVTFALISSAYTTANITSAFVSSSAVFVTMAIYGSVTKRDLSKFGAHATAALVALIIASVINMFLQSPAITYIFSYIAVIIFTVLTAWDAQKMKNIYLRFGDQVSVGGLAVMGALQLYLDFVNIFISLLQIFGMSDRN
>NZ_AP014680.1|WP_041093293.1|909287_910619_+|UDP-N-acetylmuramate--L-alanine-ligase
MDNKTTYYFVGIKGSGMSALALVLHDKGFKVEGSDIDQYTFTQRGLEGAGIDIYSFDPANIHSGLTIIAGNAFPDDHPEIVAAKKLGLKIYRYHEFLGELIEGYTSIGVAGAHGKTSTTGLLAHVLSGIAPTSYLIGDGSGKGKPDARFFVFEADEYRRHFMAYHPDYAIMTNIDFDHPDYFSGMADVTSAFESFGKQVKKGIFAWGDDKNLRKLDVDVPVYYYGTGATDDFRAAEIKRTTKGSSFDVYYHDEFLGDFEIPLFGQHNILNSLAVIAVAYFEKVNLDDIKTELLTFKGVKRRFSERQVADMTIIDDYAHHPSEIKATLDAARQKYPDKEIVAVFQPHTFTRTIALLDDFATSLNLADQVYLTDIFGSVREHAGKISSADLGAKISKGGTVLKLDNMSPLLDYHDAVVVFMGAGDVQKYERAYETLLSNITPKNN
>NZ_AP014680.1|WP_041093292.1|908872_909262_+|hypothetical-protein
MTNQYDGPSFFRHPSKIGSDEIKQPERQILHNAKKTLERVYVPPVMANKKVREHLNLTKIMHQLHKASDDYYVSVSDQKMVQANKKLDKSTVKMTKQSSSNKALGHSLGDILKSEQDAQRDLAIFKHQD
>NZ_AP014680.1|WP_041093291.1|908203_908839_+|DUF4479-and-tRNA-binding-domain-containing-protein
MLIASYNQAELGDVLVVVTAADTLEQVTTVRDNIVEIVDKDDGHLIGFNFLQVQEILPNFSGNGQVKLSTEQLASLNGAIKQAGFATQLNADESSKFVIGYVKDLEKHPNSDHLHITKTIVDGNQELTIVSGSPNIAKNIKVVVAKVGAMMPSGQIIWPGQLRGVSSNGMICSGRELGLKNAPQKPGALILPDNFQEIGQPFDFDKGNLLF
>NZ_AP014680.1|WP_041095250.1|918960_919467_+|translation-initiation-factor-IF-3
MVNDGIRAREVRLIDADGNQLGVKSKQDALQLADDAELDLVLVAPKAKPPVARIMDYGKYRFELQKKQREDRKKQKVISVKEVRLSPTIDTNDFNTKLKNARKFLSKGDKVRVSIRFKGRAITHKDIGRNVLNQMASETKDIASVEQYPKMDGRSMFLTLAPNADKQK
>NZ_AP014680.1|WP_041093304.1|919490_919688_+|50S-ribosomal-protein-L35
MPKMKTNRAAAKRFKRTANGGLKSANAYTSHRFHGKTKKQRRQLRGLSMLNKTNIKRYKKLLNVK
>NZ_AP014680.1|WP_041093306.1|919725_920079_+|50S-ribosomal-protein-L20
MRVKGGTVTRARRKRVLKLAKGYRGSKHRLFKTAKNQVMKSYVYAFRDRKTNKRNYRQLWITRINAAARLNNISYSKLMHGLKLADININRKMLAELAVSDAAGFTALVDEAKKASK
>NZ_AP014680.1|WP_041093308.1|920236_920767_+|YqeG-family-HAD-IIIA-type-phosphatase
MLREFKPTWMIKSVYSIEPQQLKQQGIRAVFTDLDNTLIAWNNPDGTPELKSWMQALEDAKIPLIVISNNNYKRVRRAVEPLALPFISRALKPLGFGIKRAAKKLGLQPHEVVMVGDQLLTDMVAANQAGVYSILVRPLIATDAWNTRINRFFEQYVMKQLVAQYPMLKWQEELND
>NZ_AP014680.1|WP_041093310.1|920759_921884_+|ribosome-biogenesis-GTPase-YqeH
MTEATKEEKLICIGCGATIQSEDPQAIGYTPESAIKKGLENNELYCQRCFRLRHYNEIAPVSLTDDDFLRLLNQISDAKALIVYVVDIFDFNGSVIPGLHRFVGNNPVLLVGNKEDLLPHSLRRSKLADWMRQQANLNGIHPDAVALVSAKKNRQVDDLLELIEKRRQNRDVYVVGVTNVGKSTLINQIIKQTTGVKELITTSRFPGTTLDKIEIPLDDGHQLIDTPGIIHPDQMAHVLSDQALKIVAPQKEIKPRTFQLDEQQTIFLGGVARFDYEYGPKKGVVAYFENNLNLHRTKLSNADAFYEKHLGDLLTPPTMDEKDSFPALERHEFHVDVKSDLVIEGLGWITIPADATVAGFAPKGVSVIIRRAMI
>NZ_AP014680.1|WP_041093311.1|921899_922211_+|ribosome-assembly-RNA-binding-protein-YhbY
MELRGKQKRYLRAQAHSLRPLFAVGKEGLSDNWLDQLSGALDKRELIKVNILQNSDVTIDEVQQFIESKTNIQVVQKIGRVLVLFMVSRDESMRQLSQTVSKI
>NZ_AP014680.1|WP_041093313.1|922223_922859_+|nicotinate-nucleotide-adenylyltransferase
MQHQTTTDVTTQTITQTKTDGHKRRIGLYGGTFNPIHTSHLIVADQVGNALGLDEVLFLPDMIPPHVDAKDSINPQLRIDMIQLAIEDNPMFGIELAEVKRGGISYTFDTIKELKRVHPENDYYFIIGGDMVAYLPTWHRIDELANMVTFVGVRRLGYETKSKYPVIWVDAPLIDISSTDIRHRVETGQSVRYLVPNKVAAFIKEHRLYLE
>NZ_AP014680.1|WP_041093315.1|922851_923460_+|bis(5'-nucleosyl)-tetraphosphatase-(symmetrical)-YqeK
MNEELIYQQHLIPNTRLELISILKGALSKTRFEHVLRVEQTAIKLAKLNDVDIEKASLAGLVHDYAKQRPDQDFITIINENKMDPDLLNYSNAIWHGVVGAELVKQELNIWDEDILNAVRHHTTGAAVMSKLEQVIYMADYIEPGREFPGVETARDVTKANLSAGVSYQTKQTLQYLIEHNKAVYPETITTYNAWVADNGGI
>NZ_AP014680.1|WP_041093317.1|923459_923816_+|ribosome-silencing-factor
MDSKEILKTVVRAADDKRAEDMVALDVREVSLMADYFVIMDANSKRQVQAIAEAVVDQDQASDITVKQVEGKQTGEWVLVDLGDVIVHIFQKEQREYYNLEKLWSQAPLVNIDAWMEV
>NZ_AP014680.1|WP_041093319.1|923812_924553_+|class-I-SAM-dependent-methyltransferase
MIYASFAQLYDELFDEKLYVEWEEFVTAQINPNSNTLDLAGGAGRLATLLAKRNYSVDVADLSTEMLSLAEQHARENNVDIKLFEANMLDLSELSQYDNILCFADSLCYLKDLTQIETTFTQVNGHLTDNGMFLFDVITPYQTDYVYPDYMYNYEDEQHERAFLWQSYADEQQEHGVIHELTFFNQINKQNKYERVAETHFEKTYELDQYLAALKQANFSKVTVSADFGHQKINEQTTRWFFVCQK

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Crispr_ID: NZ_AP014680_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP014680_7

1246913-1247052

Orphan

Consensus_repeat	Method
AAACGTGTTCAGCCCTGCAGATGTCTAGGGATAATCCCACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP014680_7

>merge|NZ_AP014680|7|1246913-1247052|CRISPRCasFinder
AAACGTGTTCAGCCCTGCAGATGTCTAGGGATAATCCCACTTTACCAATCAATAAATCATAGACCGATTTATTAATCCTTCTACCCTATTTTATTGACTAAACGTGTTCAGCCCTGCAGATGTCTAGGGATAAGCCCACT

>NZ_AP014680|7|7|1246913-1247052|CRISPRCasFinder
AAACGTGTTCAGCCCTGCAGATGTCTAGGGATAATCCCACT	TTACCAATCAATAAATCATAGACCGATTTATTAATCCTTCTACCCTATTTTATTGACT
AAACGTGTTCAGCCCTGCAGATGTCTAGGGATAAGCCCACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP014680.1\|WP_041093678.1\|1246128_1246446_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|223672
NZ_AP014680.1\|WP_041093682.1\|1247133_1247877_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|226674
NZ_AP014680.1\|WP_041093690.1\|1250618_1252001_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NZ_AP014680.1\|WP_041093688.1\|1249042_1249924_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_AP014680.1\|WP_041093686.1\|1248628_1248976_-\|MmcQ/YjbR-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|377256
NZ_AP014680.1\|WP_052467315.1\|1249953_1250523_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP014680.1\|WP_041093684.1\|1247896_1248421_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180760
NZ_AP014680.1\|WP_041093696.1\|1255212_1255674_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014680.1\|WP_052467316.1\|1253260_1253761_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_AP014680.1\|WP_041093694.1\|1253840_1255166_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NZ_AP014680.1\|WP_041093666.1\|1241196_1242339_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378925
NZ_AP014680.1\|WP_041093662.1\|1237100_1237727_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_AP014680.1\|WP_041093664.1\|1239449_1240271_-\|glycosyl-transferase	unknown	unknown	gnl\|CDD\|133037
NZ_AP014680.1\|WP_041093680.1\|1246447_1246867_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380361
NZ_AP014680.1\|WP_041093674.1\|1243062_1243701_-\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|372644
NZ_AP014680.1\|WP_041093672.1\|1242370_1243006_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_AP014680.1\|WP_041093692.1\|1252200_1253142_-\|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223677
NZ_AP014680.1\|WP_041093676.1\|1243755_1245978_-\|alpha-galactosidase	unknown	unknown	gnl\|CDD\|225882
NZ_AP014680.1\|WP_041093663.1\|1237757_1239131_-\|Nramp-family-divalent-metal-transporter	unknown	unknown	gnl\|CDD\|234815
NZ_AP014680.1\|WP_041093665.1\|1240474_1241200_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054

Protein	Function_ID	Function_description	E-value
NZ_AP014680.1\|WP_041093678.1\|1246128_1246446_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|223672	COG0599, COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown].	1.02457e-30
NZ_AP014680.1\|WP_041093682.1\|1247133_1247877_-\|SDR-family-oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	1.70052e-96
NZ_AP014680.1\|WP_041093690.1\|1250618_1252001_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NZ_AP014680.1\|WP_041093688.1\|1249042_1249924_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	3.61227e-45
NZ_AP014680.1\|WP_041093686.1\|1248628_1248976_-\|MmcQ/YjbR-family-DNA-binding-protein	gnl\|CDD\|377256	pfam04237, YjbR, YjbR. YjbR has a CyaY-like fold.	2.25717e-17
NZ_AP014680.1\|WP_052467315.1\|1249953_1250523_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	6.53766e-09
NZ_AP014680.1\|WP_041093684.1\|1247896_1248421_-\|hypothetical-protein	gnl\|CDD\|180760	PRK06934, PRK06934, flavodoxin; Provisional.	1.32919e-22
NZ_AP014680.1\|WP_052467316.1\|1253260_1253761_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	6.86302e-07
NZ_AP014680.1\|WP_041093694.1\|1253840_1255166_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NZ_AP014680.1\|WP_041093666.1\|1241196_1242339_+\|ABC-transporter-permease	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	6.5898e-29
NZ_AP014680.1\|WP_041093662.1\|1237100_1237727_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.01554e-15
NZ_AP014680.1\|WP_041093664.1\|1239449_1240271_-\|glycosyl-transferase	gnl\|CDD\|133037	cd04194, GT8_A4GalT_like, A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.	2.34387e-39
NZ_AP014680.1\|WP_041093680.1\|1246447_1246867_-\|cupin-domain-containing-protein	gnl\|CDD\|380361	cd02233, cupin_HNL-like, Granulicella tundricola hydroxynitrile lyase (GtHNL) and related proteins, cupin domain. This family includes archaeal, eukaryotic, and bacterial proteins homologous to hydroxynitrile lyase from Granulicella tundricola (GtHNL), a novel class of HNLs that does not show any sequence or structural similarity to any other HNL and does not contain conserved motifs typical of HNLs. HNLs comprise a diverse group of enzymes that vary in terms of their substrate specificity, enantioselectivity and the need for a co-factor. In plants, they catalyze the reversible cleavage of cyanohydrins, yielding HCN and aldehydes or ketones. Also included in this family is TM1010 from Thermotoga maritima, a protein of unknown function. Some but not all members of this family have N- or C-terminal carboxymuconolactone decarboxylase domains in addition to the cupin domain. Members of this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	7.67592e-47
NZ_AP014680.1\|WP_041093674.1\|1243062_1243701_-\|pentapeptide-repeat-containing-protein	gnl\|CDD\|372644	pfam13599, Pentapeptide_4, Pentapeptide repeats (9 copies).	3.13811e-13
NZ_AP014680.1\|WP_041093672.1\|1242370_1243006_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.22557e-15
NZ_AP014680.1\|WP_041093692.1\|1252200_1253142_-\|zinc-binding-alcohol-dehydrogenase-family-protein	gnl\|CDD\|223677	COG0604, Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only].	8.12903e-33
NZ_AP014680.1\|WP_041093676.1\|1243755_1245978_-\|alpha-galactosidase	gnl\|CDD\|225882	COG3345, GalA, Alpha-galactosidase [Carbohydrate transport and metabolism].	0
NZ_AP014680.1\|WP_041093663.1\|1237757_1239131_-\|Nramp-family-divalent-metal-transporter	gnl\|CDD\|234815	PRK00701, PRK00701, divalent metal cation transporter MntH.	0
NZ_AP014680.1\|WP_041093665.1\|1240474_1241200_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.13334e-80

>NZ_AP014680.1|WP_041093680.1|1246447_1246867_-|cupin-domain-containing-protein
MAKNESVKNGIIFPMGPKNDAYAQYFVGQSYLQVLVNDPNVNVGVGNVTFEPGCRNNWHIHHDGFQILLATGGEGWYQEAGKPAQRLVPGDVVVTHDGVKHWHGATKNSWFSHIAITAGTPEWLEPVTDEQYAAVEEAK
>NZ_AP014680.1|WP_041093678.1|1246128_1246446_-|carboxymuconolactone-decarboxylase-family-protein
MAKKQTAGRDNLGEFAPKFAELNDDVLFGEVWSREDKLSLRDRSMITVASLLTQGVPQLDAHMKIAKQNGVTKDEMVELITHLAFYAGWPKAWSAFALAKEIYGE
>NZ_AP014680.1|WP_041093676.1|1243755_1245978_-|alpha-galactosidase
MSIYVDHNYFHLQTDHTSYIFRVMENGELGQVYFGSKIHRKSAYDNLVIREEHTATPAWKMDQPDFQPELIKQEYASFGKGDFRYPAFQITADNGSRISEFTFEKYTLTAGKKRLAALPSSFDDTNDDAETLTILLKDKVTKIELDLSYTVFPNQDVIIRSSQFTNRGTQTAVLNRALSSQIDLPDANYDFIQFSGSWARERQMVRTQLRSGIQNISSLRTASSHQQNPFFMLARPQTTDDHGEVFGFNLIYSGNFLDQVEVDQYDVSRILVGINPAEFAWNLAPNESFQTPEAVISYTDQGMNQLSQQMGAFYMQHLVNPHFAKQERPILINNWEATYFDFNEDKLMKIVNAAKTLGIEMFVLDDGWFGHRNDDKTSLGDWFVDPQKFPNGLAHLADRIHAQKMQFGLWFEPEMISIDSELYQNHPDWMIGAPNRQLSPGRNQFVLDMSRTEVVDYLFEAMSKIITSTKLDYIKWDMNRNITEMFGASLAANEQLEMPHRYILGVYQLYNRLITAFPSVLFESCASGGGRFDLGMMYYAPQAWTSDDTDAVERMHVQFGTSYGYPQSMMGAHVSAVPNDQTGRITPLKTRGDVAYFGDLGYELDITKLSSTEKEAVKQQITFYKKYRRLFQFGNFYRLDNPFENDGNVISWAVVNKDKSCAIGARYQLLNHPNPAYIRLRFKGLDPAKKYVINHGTEKFYGDELMHAGIFVTRSLGKTMDVTDSSDFNSRLFILTQKDD
>NZ_AP014680.1|WP_041093674.1|1243062_1243701_-|pentapeptide-repeat-containing-protein
MQAPKVTEAMLTPKSFLQIYDDEDLLLENGLIKNEILEQQNEDHPMLETCIVDHVIFNGSEITRFEATDVIFTNCDFSNCNFSEATFYRVQFLNCKMVGINLNGSYLNNVEFKNCLLNLASLNIVNAKDVNFVECRLAEASFNENKLKKIKFEQCDIDKMAILETNMRNVDISTCEFESLEAQQELIRGMQVNEQQATYFANYFLGVKIKLI
>NZ_AP014680.1|WP_041093672.1|1242370_1243006_+|TetR/AcrR-family-transcriptional-regulator
MNPTIFKNYRQWLLDQPMPKGKRSVLLAGLELFAQQGFNGTSTAQIADKAGVSQATIFKYFKTKQDLLLSILQPIIENFFPLYRDDFLDSLSQFKTLQELIHFIVRNRYQFLKDNADAVLIFTTEMLTNDTARELFTNIIKKSLPIIYSKLIMKIKKFNLRTELDFPIVFRTIISQTLAYFFQRQFISTLPVDEDHDLQLIEDQILRSVGA
>NZ_AP014680.1|WP_041093666.1|1241196_1242339_+|ABC-transporter-permease
MRTYAIMTRVLKELIRDKRTLALMFIAPIFILILMNLIFSANQTTNITVGTVSVSQSLNKDLGKSKHVDVKTYSTKTDAKKALKNETIDAVIKKNGNNYNLTYANTDSSKTTATKMAFKNALTTNSTKTLQSHLTTATTALAKLKSQLPAAAAQSTQQAPTATKQAAPKITNHYAYGDSNTGFFNKILPILMGFFVFFFVFLISGMALLKERTSGTLDRLLATPVKRYEIVFGYMASYGILAVFQTILIVVVTIWLLGIEVVGNVFGVIVVNLVLALVALAFGILLSTFANSEFQMVQFIPLMVIPQIFFSGIIPLDSMAGWVKDISYVIPIKYSGDAATKIIMNGQGLLDVLPDIGVLLVFLIILTILNIRGLRRYRKV
>NZ_AP014680.1|WP_041093665.1|1240474_1241200_+|ABC-transporter-ATP-binding-protein
MVETTISLTHLVKKFGDQTVLADINLNVTKGEIVGLIGPSGAGKSTVIKTTLGMEVADGGKATVFGQTMPKRKLLSRIGYMAQTDALYESLSGQENLQFYAQMKGLSKVETQKEINHVATVVDLTPDLKKRVSGYSGGMMRRLSLAIALLGTPELLVLDEPTVGIDPALRRQVWKELNQLRDEGRSILITTHVMDEAEQVDKVALLLGGKVMAFDTPEILKAQYQVDTIEDVFLKAEGVEK
>NZ_AP014680.1|WP_041093664.1|1239449_1240271_-|glycosyl-transferase
MNVLYCGDQNMKDGLLISILSLLKEEPRVLKIFIVTAFIDAGDKKYYPLSNQDVGVLDTLVKQHNSDNQVLKIDITDMFAAQVPQNNLTTVFTPGCMLRLFADELPELPNKILYLDTDVICRKDFSLFYAQALKDTELVGVLDHYGKWFFHHSASKLDYINSGVMLLNLDMIRKTQLFVRCRQLCQSKKMFMPDQSAINKLATTKKIMPRRFNEQRRLHKNTVFQHFTTSFRIFPWIHTLTVKPWEVERVHKQLKLHEYDDILAQYSQLIGKM
>NZ_AP014680.1|WP_041093663.1|1237757_1239131_-|Nramp-family-divalent-metal-transporter
MKINIAQSEDKKFVQGTDGSNKSLDEVNGSVKVPDNAGFWRTLLAYTGPGVLIAVGYMDPGNWITSIAGGAQFKYSLLSVVLISSLIAMLLQAMSAKLGIVTGKDLAQLTRERTSKGVGIGLWVVAELAIMATDIAEIIGSSIALKLLFNIPLIVGILITTADVLILLLLMKLGFRKIEAIVATLVAVIVMVFAYEVLLAEPSIGGILRGYVPTDAIVSNHSMLYLTLGIVGATVMPHDLYLGSSISQTREIDRSDEKKIAKSIKFSTIDSNIQLFIAFIVNSLLLILGAALFYGTSSSLGRFVDLFNALSNSQIVGAIASPMLSMLFAVALLSSGQSSTITGTLSGQIIMEGFIRLKMPLWAQRLITRLLSVTPVLIFAIYYHGNEAKIENLLTFSQVFLSVALPFAVIPLVMFTSDKKLMGRFANRAWVKYSAWISTIVLVGLNVYLILQTVGLI
>NZ_AP014680.1|WP_041093662.1|1237100_1237727_-|TetR/AcrR-family-transcriptional-regulator
MSNGVPNDEHEQQKNKILAVARESFTQKGFEATTTRQINKQAGISEGLLYYYFPHGKREILDAIIYQGIVERTKFIGLSFGDVNSVKDIEQQMTGFFDQVWQVFKKEENYQSFMITIRERMLLTDDQSKWLLDLMNTILGSLVEFLTKSFQKLSIDTSNVQQIAEIIMSIFQKVIYDELLIKNDRKTSSAVVAGVEQQIHVLLTLVSK
>NZ_AP014680.1|WP_041093682.1|1247133_1247877_-|SDR-family-oxidoreductase
MAITNKVVVITGASSGIGEATAKLLASNGAKVVLGARRESRLQEIVTEIKTNGGQADYSVTDVTKPADVQRLVDKAKSVFGGIDVIFNNAGIMPSSPISALHTDEWNQMIDINLKGVLNGVAAVMPDFTSQKSGQIITTSSVAGIKSFAGAGVYGATKFAVRNLMEVIRMESAQEGTNIRTVSLYPVAINTELLGTITDRESKVGMEEFYQQVGITPDAVARVVNFAVDQPEEVNVNEFTIYPTKQA
>NZ_AP014680.1|WP_041093684.1|1247896_1248421_-|hypothetical-protein
MAVIIYFSRSGQNKQSGALQYINVGNTAIVAGKLEQQIGCKSVALQTIEPYETDYEATLQRSKKEEEQDKLVEIEPSDFDLTAEKQIFLGFPIWWSTIPNVVKTFLASNDLSETEIYPFCTHEGSQFGHSLDVIKLLAPQARVHSGLAVRGSKVYRSDQAITNWLKCIDVAVIK
>NZ_AP014680.1|WP_041093686.1|1248628_1248976_-|MmcQ/YjbR-family-DNA-binding-protein
MTRPELIKLVTDYTDSYEDYPFNGGKSRETTLWTVMKQRSSNKIVALIFEKDDQLMIDLKLEPEHGVVMRNYRGVFPGYHMNKTHWNTIRVNDTELSNQELINMIKESDELTKKR
>NZ_AP014680.1|WP_041093688.1|1249042_1249924_-|LysR-family-transcriptional-regulator
MEIRLLKYFVAIAEEGTVSKAAEVLHITQPTLSRQLRELETQLDTELFTRDKNRLRLTQAGLFLKSRATEILELSDRTEQEFQSQRRQLFSGHISIGCIEADNSDTMSLMLEEFIADYPEVTFNIYTGTSDEIVDRIDKGLLDLAILLEPINTDKYHKIILPRVERWGLLVSDESFLADSKTIKPDDLTGIPLIISGRSEVQSLLSNWANKPVEAMNVIGNFNLIFNVISLVERQVGSAIGIEGAPTYTSGTKFIPFEPTMKTNCVLAWRKERETSPVVREFIRYFREAFEKC
>NZ_AP014680.1|WP_052467315.1|1249953_1250523_-|helix-turn-helix-transcriptional-regulator
MIADEAQFNIINAARELIYKNGYVETNMNDVRKRANVSKEELEKYFTSKKEIVLAVIDQVTDFWNKHLIQDILGKSLAKPAINAMFDWIMDLNSKSDEQFSYSISNILYELYNVDKDFAGKIDAFTNSWSSALAVKIAKLHPWIGTAKSELQAKNAVKLLQSTMIMTKMTGQIAPVKSAITGIKLKINL
>NZ_AP014680.1|WP_041093690.1|1250618_1252001_-|class-II-fumarate-hydratase
MPNYRTEADTLGPVKIPADALWGPQTQRSLQNFSTGAKMPLVLIKVLLQIKKAAATANAELNAISTDKADLILAAINHLLSLDDTELRQDFPLVVYQTGSGTQTNMNVNEVVANMAAKLNPEIKILPNDDVNHGQSSNDIFPTAMNITAALAIVKLKTAVQHLIDQLAVKQKEYWRVVKIGRTHLQDATPITFGQEISGWKSMLEHDLGYLNELSSTLHELAIGGTAVGTGLNAVPHFATMIAQQMSTVYGIEFTADSNKFYGLAAHSGLNVVHGALKTLAGDLMKIANDVRFLASGPRAGYGELNLPANEPGSSIMPGKVNPTQAEAITMAAVRVIGNDVVVSMAASQGNFEMNVYKPVIISTFLESAELLTGTITSFTDLMIAGLTVNADRMEELVDRSLMTVTALSPHIGYHDSAKIAQQAQKDGVTLREAAIESGKITAAQFDQWIDPVKMTGIDD
>NZ_AP014680.1|WP_041093692.1|1252200_1253142_-|zinc-binding-alcohol-dehydrogenase-family-protein
MKAAVVNNFEQVPQYQSFEKPQPQTKEQLIQVRAASVNHRVQSQADGTHYTSDGKLPFIPGLDGVGQLADGRLAYFVTSNPIYGSLAEQTVVDHRRIIPLPSDIDVNSVAASMNPAMSSWMALKSRLGTDINSKKIMILGATGNSGSLAVEISHYLGAKSVVAIGRNRDKLAKLTAEKTISLLDEPAKLKQEIKEVADVDVVLDYLWGDAAKQVMLALLPARSNHSQSLTWIEIGSMAGADLVLPSAALRSINLNLIGSGQGSIDPKLFLTELPALAQLISQGKFNVDVEAVPLDQVTSKWNLKTDRRLVFNP
>NZ_AP014680.1|WP_052467316.1|1253260_1253761_+|MarR-family-transcriptional-regulator
MTDQTTQLLAAIRTAQQQHERFKVGFWQFALNNLASEIPAAIITQFESLKMTHSEMEILSQLTTFKTNLVPYKTLQAQVSFSQGMFSRYINRLAKTELITKTKQPDNKKEVLLTITQTGRYVAKLHTRMHQLEQEHNEAVLAQFSKDEVQTTIKVLNSLNSNETEL
>NZ_AP014680.1|WP_041093694.1|1253840_1255166_+|replication-associated-recombination-protein-A
MKQESLFTDENKQNSPLANRVRPQTLDEFTGQQHLLAPGQVLRDIIDQDQLPSIIFWGPPGVGKTTLARIIANKTKSHFITFSAVTSGIKDIRKIMEEAEDNRELGEKTIVFVDEIHRFNKAQQDAFLPFVEKGSIILIGATTENPSFEINSALLSRCKVFVLKQLEVEDIIELLHKALAHPNAFPKLTINIDDDSIRLIAESANGDARIALNTLEMVILNASHDQNTVTIDQHNLNQLINTKSLRYDKNGEEHYNIISALHKSMRNSDVDAAIYWMSRMLDGGEDPLYIARRLVRFASEDIGVADTKALELTINVFQACQFLGMPECDVHLTEAVIYLSLAPKSNSVYKARLNAKKDVKKSGNEPVPMQIRNAPTKLMDELGYGKDYQYAHSQEDKLTSMKTMPPDLADHQYYFPSDQGNEQRFKQRLEYIKNWHTNHDQ
>NZ_AP014680.1|WP_041093696.1|1255212_1255674_+|hypothetical-protein
MAYKVDFKDVSTVGLESSPVATALAGLRANEARYYWNKYKHIFITVPAKDDLETLKWIETILMEKEMSFPYKPLEVTSFEVDGLRMAYVFYENGLTVNVMYSVASDGKRAVGFKLSDGMEIPQEFEGKFKFARQKSKLAGTIRGSFFVIKGTY

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Crispr_ID: NZ_AP014680_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP014680_8

1293331-1293447

Orphan

Consensus_repeat	Method
CCGCAGAAGCTTGCGTGTAACATCAAAATAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP014680_8

>merge|NZ_AP014680|8|1293331-1293447|CRISPRCasFinder
CCGCAGAAGCTTGCGTGTAACATCAAAATACTGCTATGGGTGATCAAAAAGCTCTCTTTATCTTGGTTGTCGAAATGTGTTTGCAACCGCAGAAGCTTGCGTGTAACACCAAAATAC

>NZ_AP014680|8|8|1293331-1293447|CRISPRCasFinder
CCGCAGAAGCTTGCGTGTAACATCAAAATAC	TGCTATGGGTGATCAAAAAGCTCTCTTTATCTTGGTTGTCGAAATGTGTTTGCAA
CCGCAGAAGCTTGCGTGTAACACCAAAATAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP014680.1\|WP_041093734.1\|1288494_1288944_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_AP014680.1\|WP_041093757.1\|1299563_1300220_+\|VTT-domain-containing-protein	unknown	unknown	gnl\|CDD\|182775
NZ_AP014680.1\|WP_041093744.1\|1295277_1296642_+\|ISLre2-family-transposase	unknown	unknown	gnl\|CDD\|284250
NZ_AP014680.1\|WP_041093740.1\|1290116_1293254_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_AP014680.1\|WP_041093729.1\|1283933_1285073_-\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|273657
NZ_AP014680.1\|WP_052467323.1\|1285667_1286972_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223362
NZ_AP014680.1\|WP_041095343.1\|1287503_1288004_-\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|238269
NZ_AP014680.1\|WP_041093731.1\|1285077_1285671_-\|non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl\|CDD\|238285
NZ_AP014680.1\|WP_041093763.1\|1303853_1304207_-\|DUF1801-domain-containing-protein	unknown	unknown	gnl\|CDD\|227933
NZ_AP014680.1\|WP_041093736.1\|1289031_1289397_-\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611
NZ_AP014680.1\|WP_041093746.1\|1296982_1297282_+\|heavy-metal-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|376657
NZ_AP014680.1\|WP_041093760.1\|1303401_1303776_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014680.1\|WP_052467324.1\|1300379_1303193_+\|YfhO-family-protein	unknown	unknown	gnl\|CDD\|370572
NZ_AP014680.1\|WP_041093749.1\|1297313_1297511_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014680.1\|WP_041093751.1\|1297984_1298191_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP014680.1\|WP_082232324.1\|1287996_1288368_-\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
NZ_AP014680.1\|WP_041093733.1\|1286934_1287504_-\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472
NZ_AP014680.1\|WP_041093742.1\|1293532_1295023_-\|ABC-transporter-substrate-binding-protein/permease	unknown	unknown	gnl\|CDD\|223836
NZ_AP014680.1\|WP_173406308.1\|1298357_1299383_-\|sugar-kinase	unknown	unknown	gnl\|CDD\|238571
NZ_AP014680.1\|WP_041093738.1\|1289495_1290071_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
NZ_AP014680.1\|WP_041093734.1\|1288494_1288944_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	6.24545e-21
NZ_AP014680.1\|WP_041093757.1\|1299563_1300220_+\|VTT-domain-containing-protein	gnl\|CDD\|182775	PRK10847, PRK10847, DedA family protein.	9.71921e-70
NZ_AP014680.1\|WP_041093744.1\|1295277_1296642_+\|ISLre2-family-transposase	gnl\|CDD\|284250	pfam06782, UPF0236, Uncharacterized protein family (UPF0236).	2.56581e-32
NZ_AP014680.1\|WP_041093740.1\|1290116_1293254_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	2.50518e-76
NZ_AP014680.1\|WP_041093729.1\|1283933_1285073_-\|dihydropteroate-synthase	gnl\|CDD\|273657	TIGR01496, Dihydropteroate_synthase, dihydropteroate synthase. This model represents dihydropteroate synthase, the enzyme that catalyzes the second to last step in folic acid biosynthesis. The gene is usually designated folP (folic acid biosynthsis) or sul (sulfanilamide resistance). This model represents one branch of the family of pterin-binding enzymes (pfam00809) and of a cluster of dihydropteroate synthase and related enzymes (COG0294). Other members of pfam00809 and COG0294 are represented by model TIGR00284. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid].	1.48015e-80
NZ_AP014680.1\|WP_052467323.1\|1285667_1286972_-\|hypothetical-protein	gnl\|CDD\|223362	COG0285, FolC, Folylpolyglutamate synthase [Coenzyme metabolism].	8.09037e-100
NZ_AP014680.1\|WP_041095343.1\|1287503_1288004_-\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|238269	cd00483, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.	7.26526e-65
NZ_AP014680.1\|WP_041093731.1\|1285077_1285671_-\|non-canonical-purine-NTP-pyrophosphatase	gnl\|CDD\|238285	cd00515, HAM1, NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides such as XTP to XMP and ITP to IMP, but not the standard nucleotides, in the presence of Mg or Mn ions. The enzyme exists as a homodimer. The HAM1 protein may be acting as an NTPase by hydrolyzing the HAP triphosphate.	2.43235e-39
NZ_AP014680.1\|WP_041093736.1\|1289031_1289397_-\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	6.58694e-32
NZ_AP014680.1\|WP_041093746.1\|1296982_1297282_+\|heavy-metal-binding-domain-containing-protein	gnl\|CDD\|376657	pfam01906, YbjQ_1, Putative heavy-metal-binding. From comparative structural analysis, this family is likely to be a heavy-metal binding domain. The domain oligomerizes as a pentamer. The domain is about 100 amino acids long and is found in prokaryotes.	0.00172577
NZ_AP014680.1\|WP_052467324.1\|1300379_1303193_+\|YfhO-family-protein	gnl\|CDD\|370572	pfam09586, YfhO, Bacterial membrane protein YfhO. This protein is a conserved membrane protein. The yfhO gene is transcribed in Difco sporulation medium and the transcription is affected by the YvrGHb two-component system. Some members of this family have been annotated as glycosyl transferases of the PMT family.	2.55452e-66
NZ_AP014680.1\|WP_041093763.1\|1303853_1304207_-\|DUF1801-domain-containing-protein	gnl\|CDD\|227933	COG5646, COG5646, Uncharacterized conserved protein [Function unknown].	1.04173e-25
NZ_AP014680.1\|WP_082232324.1\|1287996_1288368_-\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	2.44636e-40
NZ_AP014680.1\|WP_041093733.1\|1286934_1287504_-\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	4.72641e-94
NZ_AP014680.1\|WP_041093742.1\|1293532_1295023_-\|ABC-transporter-substrate-binding-protein/permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.16359e-88
NZ_AP014680.1\|WP_173406308.1\|1298357_1299383_-\|sugar-kinase	gnl\|CDD\|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	8.70608e-78
NZ_AP014680.1\|WP_041093738.1\|1289495_1290071_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.55035e-07

>NZ_AP014680.1|WP_041093740.1|1290116_1293254_+|MMPL-family-transporter
MAKFLKNHVGSLIAWIVVLILAVFMLPNINQLTREHSTIDLPKDSQSQIADSIQKKWGYHQGNTYQVVAVFNNGNSAMSKTDRQNVQSTINELKKHKSEYGIKSITAPNDNSETKSQLISKDKSTQLVQLMISKDHGTVKKINQQLTKSIKTSGVKSYITGSDILNDDFSGAIQDGIKKTEIISVIFIFLVLVLVFQSPIVPLISLLTVGVSFITSLSIVTNLVEKFNFPFSNFTQVFMVIVLFGIGTDYNILLYNQFKDELSRGISNWKAAQRARRVAGKTILYSGSSVLIGFSALALAKFSIYQSAIGVAVGVAVLLVVLLTLNPFFMAVLGKKMFWPSKNFDGEGTSSLWHRLSSSSVIHPIISIFAVLIILLPFYFTFNHPLNYDDTDEISNSTPAKQGFLTVQDHFSKGTAEPSTLYIRSNHRLDNEKDLKLIDEITRKLQADPDVKTVASVTQPGGTKVKKLYVSNQLGTVNSGLTSAQKGLGQLSTGSQQMTTGLGQLSNGSQQLVDGVSQLTSQLNSQLSGSNAAQIAQLESGLPQINNGIQQLNSALQQSGSSIDTSSLTSELTNVGNQAQVIGTNLTQAGNTLQGLQGQSSSSSDSANQIIQAANQNGASLQPGQQAVLSAVITSALNKQSQSLEGSLSSVAANIQAAGNADKSLAGSMTSVSNSAGSLNSMMSQVATLKTEVNQLATASNTALPGAATALTQLTSGLNQVQSALGSSQSGLIQINTGINQLADQSPQLTSGIDKVNSGLGSGGSYLKALKKSAAADSYYVPKNILHSKSYKPAIKAYLSEDKKSAKITVVLGTNPSDATATKKVRTLSNMAKKNLKGTDLKNATVAMGGQSSTLADTKSLASQDFIRTAAIMLIGIALALVFVTRSLLQPVYIIGTLMIAYMTSLSLTRWLTHLILGRDMLTWNTPFFSFIMLIALGVDYSIFLMMKYREFGRDNMMPSKRIVKSAGIIGTVVISAAIILCGTFAALIPSGVPTLIEVAMAVIIGLIILVFIIPIMIPSTIRLTYPVKSGFQDAEKREDDNKKK
>NZ_AP014680.1|WP_041093738.1|1289495_1290071_+|TetR/AcrR-family-transcriptional-regulator
MTKKRNLDQEKVLSTATEIVRNEGIKALTLSRLASELDIRTQSLYNYIANLDELIALVGARLVNKLRQKITDGILGFSGTEALIKFADIARNFLLDEGTLGVIIFYLHEYPKDSPFNTEAQKLVALLNQVIDSSHTNVGTDAPFSHALIGSVLGFVFIETSGFYQDETDASSTESYHQMIKRIITPSGEPA
>NZ_AP014680.1|WP_041093736.1|1289031_1289397_-|HIT-family-protein
MNNECVFCQKTSRDFLLENDLSAAFFDFAPVSRGHTLIIPKRHVEEVWQLQTAELKAMWELIEQTKQYLDAEYYPDGYNIGVNAGTAAGQSVMHCHVHLIPRYVGKSPRVPGVENLIPPAR
>NZ_AP014680.1|WP_041093734.1|1288494_1288944_-|MarR-family-transcriptional-regulator
MTDKVVLDNQLCFQINRAHQLFNRFYQSPLKKFELTYAQYTVLLALWEHQGVTINQLGDKLGLGTGTLTPLLKRMETAGWLTRTRSTEDERRVIVNLTSKAVQSKSSILEETSNCISKLDFDDSTYQKAMDTIDDIQHRLDKSVDQRER
>NZ_AP014680.1|WP_082232324.1|1287996_1288368_-|dihydroneopterin-aldolase
MGKIRINNMSFHTYNGVFAEEKKLGQKLQLDAELSYPIEQLVQHDDLKETVSYADVYQTIEDFVLSNNYNLIESVANHLLQKLLATYPTIEAITLRVRKYSVPIAGIFDNVEIEVSGAQKHDD
>NZ_AP014680.1|WP_041095343.1|1287503_1288004_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MTSRAYLSIGSNIGERQANLQQAVEQLKANQQIKVVRVSSIYETQPVGGVKQDDFLNIAVAIQTSLNPNVLLDYLHEVEQALHRKRLVRWGPRTIDLDILYFDDLVSADKTLTLPHPEIKNRLFVLVPMEEITADDPKKLQQIKSMINTTSDQNWVRKYNDGGELI
>NZ_AP014680.1|WP_041093733.1|1286934_1287504_-|GTP-cyclohydrolase-I-FolE
MDEKRIENAVKEILNAIGDDPNREGLVETPARVAKMYGEVFASLDEKATFDDYKVFHVDEDPGMVLIQQIPFYSMCEHHLLPFFGTANVAYVPRDGKIMGLSKIPRLVDFVAKRPGVQERITTQIVAQMEQILHPKGIAVSLSARHMCMEMRGISKSGLFTYTSKFEGVFKDDLELKNEFLRQTGNHSE
>NZ_AP014680.1|WP_052467323.1|1285667_1286972_-|hypothetical-protein
MNFYGKRGIIVNNYEELLKHMNQAMLANDDDRVALVRRVLAAINHPDLNFKVVHLAGTNGKGSTGSLVAQMLINQGYKVGHFSSPALVDQREQIVINHQQITTTDFVRIYNWISERLPGDISADDLTVFEWFVLIMLQYFSDQKVNWAIVEAGLGGKDDATNAIQPPLVTVFTHIDLDHTKILGNTIKKIAYNKSQIIKPKTTVFVAPNQHHDAITVLNDVARKNQAQAVFDSNDIQVEVAERKITGTNLLVTSRYLDHVAVTLKMLGDFQIDNFKNVVAIYDWLFEQQIVSAPAVLINAAAQVTIPGRLEVLQTNPVVILDGAHNPDAAQRLIGSLHVLFSDRRFVFVLGFLRDKNYQLMTKLYSQVADRIFATTPDNGSRALPATQLQQLLPTSQVVTTAQQGIDEALKLADKQTVIIVTGSFYVVKELFKK
>NZ_AP014680.1|WP_041093731.1|1285077_1285671_-|non-canonical-purine-NTP-pyrophosphatase
MKTLPTFVIASNNSNKTNELIECFNFLGLHAQSYQDFIAPLEFPNEATTTYLDNARGKALFIAKYLPEEWVIADDSGMELQALPDELGVTTARQLKPCQNMNELNDKILALVANKSRIVKMVSQLVLITSNKVEFIARGEFKGTIATRECGTNGTSFDLILVPQGMQQTLAQLPDREKLPLLHRTKAIKNLISQLGD
>NZ_AP014680.1|WP_041093729.1|1283933_1285073_-|dihydropteroate-synthase
MQVQEIKFEATNDFKSLVLHDMALRQRQLFLQFHLQSSDDLKALVGLLNRFDVISQIGQLIVTCSVSPAILPILKEQCFSMWHDWQLNEEFESIEQQHTIFWQAGRFNFNVTKQPIIYGILNVTPDSFYDGGRYQSESQMSEQIAAMVTAGANVIEVGGQTTRPGFEEITDQMEIDRIAPAIKIITARFPRVAIAVDTYKLNVMHAVIEMGVDIINDVNAFTDDTRKLQLLSPTKVGLLTMHSSRNHEYQNLTQEMRHFFEQNIATIMDSGVARQRIALDQGIGYSKVADGYQDYAMMRNIDQFNYLQRPMMIAISRKGFGAKLFGLAKEDRLPVTLVAEAYMYLHGGNILRVHDVTETVQLVKMLDEIKKGYWIKKQE
>NZ_AP014680.1|WP_041093742.1|1293532_1295023_-|ABC-transporter-substrate-binding-protein/permease
MKKIQHLLLALLLVLTMTVSACLATTQPVEAASTTKTDQTLQKIKKQGYITVGLSADYPPFEFHKTINGEDKIVGFDVSLAKKVAKQLGVKLRINEMQFSSLLGALKTGKIDMIISGMNSTPARAKEVSFSKNYLSVQERMLIRTTDKNKFKTTQDFSGHKVGAQTESTELEFVQNQLTGSTPVSLAKFTDLVLQLNNKKIDGIVTQTPIGKAYANQSKTLTMINPGFTSGTKQTNVAVSKDAPALLAHVNKTITYVDKHNLMDKYQKTANKLMFSKQNFLQQYGNYYVTGVEITVALALIGVIFGTLLGTLLAMMRRSKIWLVKAIGAVYVEYTRGTPLLVQVFIVFFGTQILGLHVSAFVSSSLAMGMNSGAYVSEIIRGGINSVDTGQDKAARSLGLASGQSMRYVILPQAFKNILPALGNEFISVIKESSIVSVVGVGEIMFQTGVIQGASFKPFFPLIIASLLYFVLTFGLSRLLRLVEKKFNLSSDSNIV
>NZ_AP014680.1|WP_041093744.1|1295277_1296642_+|ISLre2-family-transposase
MFILADFIDSLKNLDSLFDLEEQVIRCLREMFQEIVSKYLIQLDETLVSQIPSDHTFINRQPRTINFMFGAVSFERRCYRKTDGTNYFPLDTHLKLASRKRFSPYFKSVVSKIGQMTTMRNTADMINLASQTDISAWAVDKIVREMADIVAVEEETLDKEIVHRKKVDNLVIEGDAFEVRERGKQRVSVHHYKVYESTNAGPVNKREFVETNHLKARKQVCDYLEAHYKLSEMVVFLASDAAPGYDPISMRELVPGAKKVEYVIDRYHFIRKFEQTIGLQNPLSRKATAAIRGHNLNQLEAILDTFESQITTGKDSEKLIKLRHYLSRNWKYIKRPKDRGYKYMGKLGSVESSHRAFTYRLKKQGKSWSKEGLQAMLVLILARVNRHLNQDLSSGLRRLRELKIEVSLESIKSIRFTDLNRKTRSHHIGVKIGNITVDSSTSSPIGAMAKAYSR
>NZ_AP014680.1|WP_041093746.1|1296982_1297282_+|heavy-metal-binding-domain-containing-protein
MFLTTGSIDKPHVIKGIVNATSHLMLASETIDAFESMDQLFPDVQEKMKQRASDNGADGIINIKFNTEIAQLQVAPKFLVVTGYGTMISFLDNKTDESK
>NZ_AP014680.1|WP_041093749.1|1297313_1297511_-|hypothetical-protein
MSRIELINYAMEVATKNKMQLLVESAYDVKFVNVKTKQQTEIAQKFIDLHADEVFSGKPLKFKME
>NZ_AP014680.1|WP_041093751.1|1297984_1298191_-|hypothetical-protein
MNKIILKADLTEKQKEQVILEFSKTWKNVESINCQTCKDGTITNYNINYVCDEKGRSGTIKEVNLIFN
>NZ_AP014680.1|WP_173406308.1|1298357_1299383_-|sugar-kinase
MMKILTFGEMMLRLKTPDNERLIQANKFEVSYGGSEANVAVSLALLDDNAAFLTKLPPNLLGDSAEATLLKHHVDTGGIHRGGARMGIYFFEKGASVRPTNVVYDRAGSSFSTVDANEFNWEKILTDVDYFYFSGITPALSDQLQLATLKACQYCQTHQIPIICDLNYRSKLWSPEKAQKVMGELMQYVNVCLAHDEDFIATLGIEAFDGDMRHGIEQKDQFKKSMKAVTEKYPQCHTIASVLRDINSVEDSQWTSILLRDGKFYEAPIYQMHVMEGVAAGDAFGAGIVHGLVNNFVPQEQINYAMAASVLKLTISGDLNLVSDQEIRSLMESRGGSGMKR
>NZ_AP014680.1|WP_041093757.1|1299563_1300220_+|VTT-domain-containing-protein
MPQLIDFIMHIDQHLISIVNQFDSMTYLILFALIFIETGVVILPFLPGDSLLFAASALAANQAFNLNFGMFLVTFFVAAVLGDSLNYEIGKHTGLLVSRNSFFGRFLNQEKLDKAETFFNKHGGKTIVIARFMPFVRTFAPFISGGSKMNYRKFAFYNIIGGFLWVLVCCLTGFFFGNLPIVQDNFTFVIFGIIGVSLLPAIITYLKSKISAPQKEIE
>NZ_AP014680.1|WP_052467324.1|1300379_1303193_+|YfhO-family-protein
MSLRQKLSKNIYINYAFCFLLIGILVFAVVPISKSTLIWNSDGITQHYPALLYWRKLLRGLVFHHHLFAQWNWNIGLGSDTFQVFSYYVMGDIFTYPAILFSQAHMAAYYSILIVVRLFLAGITFIFAAKRLIPHVKPASILIASFVYVFSGYSAYVTFAHPFFLNPLIILPLLIYSINKSLTTKKTTLLFIMTAWALFNNFYLGAVMGIGMAIYWVILLITNPQLRQLKLNLKLILSVIGGIGLSAVLFVPSMYQLLNSARSSSQVANGMTVYPLAYYLTLPGMAISNYSRPYWVTGGILAIGVIAILWSLRRFRQFKTINLTFTISGIILLVPFLAALMNGGSSPSNRWTFLVMFPIAIAVIHLLDNLVTVDRKDLIIFTIAGLLMAISLFITHSFSFTFDLGGVLIIYGCFVILLLLAQNIHTINITPNKIAAIILILTSLNAVIIMRDRHTNQFSQSKTMLMTSSATQQLTNAQKAYETEATPKSADSSRSLIDGQLQNYLGKAPADNLPILAETKNINSYWSLQNTYLSKLNNELENNTGNPNDVTNNADYRSLMLQYFGVSRFFKNSDNEFEPAGYEDSGTATNSQELLTADQTIPLIYHSAGTMSQQQFNRLDPSQKEAALINNTITKKAKTTSNQTLLNQVIKVPFSYLNGDTVTKKHVSVTMPSTKIDPFITIDSTQKNIKGYELHAHISNISFHSGSLNQRYQNATNNYIQTHSEEMMLSGQDTDLRYSTQLFKLNWLRKNATSISGNTGTFSIQLGYGETTNVFEQMGNDNLSFYDPKASTTLNLGTVKSSENLVSLSLPSSGKYDFDLTLWAVPTGSAVTKAINKNTPAKNIRLQKNSVTADYQAKRSGILATTIPYSTGWHLKGSTSKLPRVNEAFVGIPIKSGHNHLQLVYQTPLLKVSFIISTVCFLSLLCLALFEFRPVKK
>NZ_AP014680.1|WP_041093760.1|1303401_1303776_+|hypothetical-protein
MTPYKIFFNNRITTNSVVVSYNASTLSNEEIFNGRIKLQLSTANGRFLKSGNVALRAIETTMMGIDTNYRLVAVTFTKPSQATILSIPDYDSFNKYVFDHGMTHGVLMVMDKNKKRIGVKIIEV
>NZ_AP014680.1|WP_041093763.1|1303853_1304207_-|DUF1801-domain-containing-protein
MKKYEHVSEYLADLAPMQREVAQIMRELLQDAAPEANEKISYNMPAIEQNGHVLVYFAPTESHLGFYPTADPIVAFKDQLKNYQTSKGTIKIPYDKPLPVKLIRVIVAYRIQQVTTN

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Crispr_ID: NZ_AP014680_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP014680_9

1720298-1720432

Orphan

Consensus_repeat	Method
TTTACTTGCTAAAACGCGCAAAAAGTCGCAAAAGTCTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP014680_9

>merge|NZ_AP014680|9|1720298-1720432|CRISPRCasFinder
TTTACTTGCTAAAACGCGCAAAAAGTCGCAAAAGTCTATTTATAAACACAAAGGGAACCATATGATTCATATTTCGAATCATATTTCGCTTCTATTTTTACTTGCTAAAACGCGCAAAAAGTCGCAAAAGTCTAT

>NZ_AP014680|9|9|1720298-1720432|CRISPRCasFinder
TTTACTTGCTAAAACGCGCAAAAAGTCGCAAAAGTCTAT	TTATAAACACAAAGGGAACCATATGATTCATATTTCGAATCATATTTCGCTTCTATT
TTTACTTGCTAAAACGCGCAAAAAGTCGCAAAAGTCTAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP014680.1\|WP_173406302.1\|1713120_1713273_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_AP014680.1\|WP_052467350.1\|1729863_1730304_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_AP014680.1\|WP_041094314.1\|1712921_1713101_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|236066
NZ_AP014680.1\|WP_041094324.1\|1724476_1725670_-\|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226643
NZ_AP014680.1\|WP_041094327.1\|1728636_1729497_-\|NmrA-family-NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|187561
NZ_AP014680.1\|WP_041094315.1\|1713549_1716897_+\|NEAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|368252
NZ_AP014680.1\|WP_041094313.1\|1712262_1712811_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_AP014680.1\|WP_041094321.1\|1722098_1722572_-\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|238207
NZ_AP014680.1\|WP_041094312.1\|1711694_1712120_-\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
NZ_AP014680.1\|WP_041094317.1\|1717624_1718512_+\|heme-ABC-transporter-substrate-binding-protein-IsdE	unknown	unknown	gnl\|CDD\|274706
NZ_AP014680.1\|WP_041094325.1\|1726296_1727451_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223551
NZ_AP014680.1\|WP_041094311.1\|1710910_1711603_-\|50S-ribosomal-protein-L1	unknown	unknown	gnl\|CDD\|180071
NZ_AP014680.1\|WP_041094318.1\|1718526_1719489_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_AP014680.1\|WP_041094328.1\|1730377_1730746_-\|iron-chaperone	unknown	unknown	gnl\|CDD\|227933
NZ_AP014680.1\|WP_041094319.1\|1719478_1720237_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_AP014680.1\|WP_041094326.1\|1727508_1728615_-\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176239
NZ_AP014680.1\|WP_041094320.1\|1720526_1721714_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380570
NZ_AP014680.1\|WP_052467396.1\|1716916_1717609_+\|NEAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|132993
NZ_AP014680.1\|WP_041094323.1\|1723628_1724477_-\|proline/glycine-betaine-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226644
NZ_AP014680.1\|WP_041094322.1\|1722717_1723626_-\|glycine/betaine-ABC-transporter	unknown	unknown	gnl\|CDD\|270357

Protein	Function_ID	Function_description	E-value
NZ_AP014680.1\|WP_173406302.1\|1713120_1713273_-\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	2.07843e-15
NZ_AP014680.1\|WP_052467350.1\|1729863_1730304_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.48292e-16
NZ_AP014680.1\|WP_041094314.1\|1712921_1713101_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|236066	PRK07597, secE, preprotein translocase subunit SecE; Reviewed.	4.76828e-11
NZ_AP014680.1\|WP_041094324.1\|1724476_1725670_-\|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein	gnl\|CDD\|226643	COG4175, ProV, ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism].	0
NZ_AP014680.1\|WP_041094327.1\|1728636_1729497_-\|NmrA-family-NAD(P)-binding-protein	gnl\|CDD\|187561	cd05251, NmrA_like_SDR_a, NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs. NmrA and HSCARG like proteins. NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. HSCARG has been identified as a putative NADP-sensing molecule, and redistributes and restructures in response to NADPH/NADP ratios. Like NmrA, it lacks most of the active site residues of the SDR family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Atypical SDRs are distinct from classical SDRs. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.79509e-29
NZ_AP014680.1\|WP_041094315.1\|1713549_1716897_+\|NEAT-domain-containing-protein	gnl\|CDD\|368252	pfam05031, NEAT, Iron Transport-associated domain. NEAT domains are heme and/or hemoprotein-binding modules highly conserved in secondary structure. They have roles in hemoprotein binding, heme extraction and heme transfer.	9.20024e-12
NZ_AP014680.1\|WP_041094313.1\|1712262_1712811_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	3.09143e-86
NZ_AP014680.1\|WP_041094321.1\|1722098_1722572_-\|glutathione-peroxidase	gnl\|CDD\|238207	cd00340, GSH_Peroxidase, Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per subunit, which is involved in catalysis. Different isoenzymes are known in mammals,which are involved in protection against reactive oxygen species, redox regulation of many metabolic processes, peroxinitrite scavenging, and modulation of inflammatory processes.	1.01012e-80
NZ_AP014680.1\|WP_041094312.1\|1711694_1712120_-\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	1.51281e-94
NZ_AP014680.1\|WP_041094317.1\|1717624_1718512_+\|heme-ABC-transporter-substrate-binding-protein-IsdE	gnl\|CDD\|274706	TIGR03659, heme_ABC_transporter_heme-binding_protein_isdE, heme ABC transporter, heme-binding protein isdE. This family of ABC substrate-binding proteins is observed primarily in close proximity with proteins localized to the cell wall and bearing the NEAT (NEAr Transporter, pfam05031) heme-binding domain. IsdE has been shown to bind heme and is involved in the process of scavenging heme for the purpose of obtaining iron.	7.52291e-126
NZ_AP014680.1\|WP_041094325.1\|1726296_1727451_+\|cation:proton-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	4.78428e-57
NZ_AP014680.1\|WP_041094311.1\|1710910_1711603_-\|50S-ribosomal-protein-L1	gnl\|CDD\|180071	PRK05424, rplA, 50S ribosomal protein L1; Validated.	3.63887e-136
NZ_AP014680.1\|WP_041094318.1\|1718526_1719489_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	2.5624e-60
NZ_AP014680.1\|WP_041094328.1\|1730377_1730746_-\|iron-chaperone	gnl\|CDD\|227933	COG5646, COG5646, Uncharacterized conserved protein [Function unknown].	7.37186e-43
NZ_AP014680.1\|WP_041094319.1\|1719478_1720237_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	1.9707e-93
NZ_AP014680.1\|WP_041094326.1\|1727508_1728615_-\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176239	cd08278, benzyl_alcohol_DH, Benzyl alcohol dehydrogenase. Benzyl alcohol dehydrogenase is similar to liver alcohol dehydrogenase, but has some amino acid substitutions near the active site, which may determine the enzyme's specificity of oxidizing aromatic substrates. Also known as aryl-alcohol dehydrogenases, they catalyze the conversion of an aromatic alcohol + NAD+ to an aromatic aldehyde + NADH + H+. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
NZ_AP014680.1\|WP_041094320.1\|1720526_1721714_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380570	cd06347, PBP1_ABC_LivK_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.	9.84052e-118
NZ_AP014680.1\|WP_052467396.1\|1716916_1717609_+\|NEAT-domain-containing-protein	gnl\|CDD\|132993	cd06920, NEAT, NEAr Transport domain, a component of cell surface proteins. NEAr Transporter (NEAT) domain; used by pathogenic bacteria to to scavenge heme-iron from host hemoproteins. The NEAT domain is a component of cell surface proteins (iron regulated surface determinants, or Isd, such as IsdA and IsdC) in various gram-positive bacteria, and may be arranged in tandem repeats.	6.31917e-12
NZ_AP014680.1\|WP_041094323.1\|1723628_1724477_-\|proline/glycine-betaine-ABC-transporter-permease	gnl\|CDD\|226644	COG4176, ProW, ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism].	1.54511e-129
NZ_AP014680.1\|WP_041094322.1\|1722717_1723626_-\|glycine/betaine-ABC-transporter	gnl\|CDD\|270357	cd13639, PBP2_OpuAC_like, Substrate binding domain of Lactococcus lactis ABC-type transporter OpuA and related proteins; the type 2 periplasmic binding protein fold. This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to betaine compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as glycine betaine and proline betaine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.70884e-68

>NZ_AP014680.1|WP_041094319.1|1719478_1720237_+|ABC-transporter-ATP-binding-protein
MKINAVCFSYPHSKHNIIDHLSYHIKPNIVTAIVGPNGSGKTTLLRMLARELIPTSGNIQLNQREISNFSNKEYAQKVAIVHQHNPIYEDISVIDLVRFGRTPYGSALNTATDDSILPILEYLELVPLKQRSMLSLSGGQQQRVWLAMALAQQPEYLLLDEPTTYLDLHFQASLMKLIARLNTDFNITVIMIVHDLNQALHYSQRTVVINHGKIIASGDPTRVLTQETLQNVFQIDADVVRTERGEFILQMP
>NZ_AP014680.1|WP_041094318.1|1718526_1719489_+|iron-ABC-transporter-permease
MNKHPILAYITTGLLLIITIIIALFVGASGFSMSTGLHALVTGHPATVLNTMLTIRLPRIVAALISGALLSVAGAFFQSALRNPIADPSILGISAGADLLMLLGGILFPAFFFTKLIFALIGGLIAFGILIIFQTKVNPYRLVLIGIAINAVLVSLKQIFTPTTGSSTSVSLSTITWSTTTILLVLGIIGLMIALIVAPLTNYLKIGDQQLKALGLAVNKVKTGLLLLGVYLTCFVTANVGVLPFLGIIVPHLSRSLVGNDYRQVIPFATIAGALLMLIADTIGRTVVIPSEIPAAALLTIIGGPYLIYILTQKGVQHEN
>NZ_AP014680.1|WP_041094317.1|1717624_1718512_+|heme-ABC-transporter-substrate-binding-protein-IsdE
MNSARKILFSVLTILLVIILVIVGLVSFNKAKSNQAKKPRIVATTMAVVQIADKLDLTLVGVPKSENPLPTKYKNVTKVGSPMSPNVEKIASLKPTVVYSVSVLKDQYDTAFKKQKFNAQYLDLDTVADLKNVLTSMGNQYDRQSQATKQIKIINNTIKTVKNRQTGQKPRVLILMGMPGAGYMIATNHSYVGDLVRLAGGQNVYTDPKQPYLAPENESLATKQPDVILRLEHAMPEVVKPQFDQEFETNSIWAQMPAVQNHRVYDLQQPDFNATANMNVRQALLKTSNWLYPAK
>NZ_AP014680.1|WP_052467396.1|1716916_1717609_+|NEAT-domain-containing-protein
MKRNFLKILLGFILTLTILILPTKVSADSINYQCLKYGTSEQSIASGYYVKPAQISANGDQYLVTMTIQTGAKLGNWPVTVLSINGAGPANVSKTRNGDNYDYSYSFQTKDLSKVINSSISINVPNVYTAKHNIGFKFDTGNLPALAATNSSNSSSQASASSTSNASSVANSSSVKKDKSKTTTKNNSSANKQIAALNKKNKQTQTAIIIGGISALVILAVAAFFFIKRK
>NZ_AP014680.1|WP_041094315.1|1713549_1716897_+|NEAT-domain-containing-protein
MKKRFLTLIAVAILCFGIIVPSVGSIGALAAADSGATETTKTDQKLDPANLADGKYTIDAPLMKSEKQTASLAQIYFNKQADLSVKNGKYSLTLHLIKDKAMVSDVTTVSDEKAATVTSTGDQTEDLTFEIANLSDVTTLSLTIHPVPTMSMAQKMDVRPDLDTLTAVQPTDSNNQATTTSENDTSSAESNTNSSSSTNASSSAATDQPATNESDAATTTNTNVETDTNETTTTLPTDPITPTNPATTPTDITDNADTTLTQAPLFNPANLSDGTYQIPVNLLKAGTSTASIAASYFSDNATVVVSDNATKITVTLHVIKNANLITAFGISDTAATISNQSATSEDLTFNVDDQFVNPTVSANMAITIPGFNKAMSENADLQFASALYIAPQPSKTTDTSTTNPSGSNTDADNVSTTTEPTSDFDPNNLIDGNYEVPISILQADSDKASVSASFFAPTATVKVSDNTQNVTVTLHITKNASTITAFSIANQNAVVSNQTKDSEDLTFNVDNTFTNAIVTAGMTIKIPVLNTEMKQQARIKFGTALYSKPATDNNNTGEGTTTDKPGSTTDQPGTSTDDGSNSSETTTADLPTFDPTNLKDGQYKIDASILKADSDNASVAASFFDPYATVTVSNNTKTVQVTLHVIKNASTISSFSLAGQNAQISDENTGSENLTFTVDNTFKDPIVGAAMTIKIPVLNTEMNEQARVKFGTALYNSPVTNETNPGKTTDNSGSNKNNNTSIPKKQETKFNLKNPKDGQYKIQAPIMQSDLTTASAAQKFIDKQATIIVSNNGSKIQLVLHLNSGAEYIKQMSIAGQQGTMTNKKGDTADLTFNISTTTLSGIGKTTFNLVTPMGSMSETAYLIFNLSNQSTAKLKALISTQTKSLNGPSRSQRGIIDPTKEVQYVPYKVLDASRTSLSTANNYYTKSAKVVKDGSGYKVFLTVKETAGMVNFTPLSINNGGFTDNSHSTTSGQDVWTYAFHVANENGLANPIAAQIMMSVSIAQITNQKFNIWLAFGKAQTGGTDYLNSNSGSALPASTLALVNSNNTAAPTLLTNTPANKKKVAASANGNHNSASENNKLASVKQYPLIAEIAGFSAAALAIIGFAFYKKYQS
>NZ_AP014680.1|WP_173406302.1|1713120_1713273_-|50S-ribosomal-protein-L33
MVAQKKVALACSVCASRNYIVAANPSRQERLEVKKYCKYCKKHTLHRETR
>NZ_AP014680.1|WP_041094314.1|1712921_1713101_-|preprotein-translocase-subunit-SecE
MHLFRFFKSVGKEMKLVVWPTARENRRDTTVVVSLTLFFILFFALFDWLIQSGLLIFAK
>NZ_AP014680.1|WP_041094313.1|1712262_1712811_-|transcription-termination/antitermination-protein-NusG
MVESVEKQWYVLHTYSGYENRVKSNLESRAQSMGMEDFIYRIVVPEQEVRQIKDGKAKESIEKTFPGYVLVEMVMTDQAWYIVRNTPGVTGFVGSHGGGSKPTPLLPDEVELVLRRLGMSARHQDLDVEVGETIKIVEGAFADLTGKITEIDKEKMKLKVNIEMFGRETATELDFDQVDKLV
>NZ_AP014680.1|WP_041094312.1|1711694_1712120_-|50S-ribosomal-protein-L11
MAKKVANVVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNARTADQAGMLIPVVISVYEDRSFDFITKTPPASVLLKKAAGVEHGSGEPNTKKVAKVTSAQVEEIAKTKMQDLNAADVQAAMRMIEGTARSMGFTVEG
>NZ_AP014680.1|WP_041094311.1|1710910_1711603_-|50S-ribosomal-protein-L1
MTQKRGKKYQDAVKKVDSEKLYAIEDAVNLVKDMDFAKFDATVEVAFNLNVDTKQADQQLRGAVVLPNGTGKEQTVVVFAKGDKAKDAQAAGADVVGDDDLVGRIQDGWLDFDVAIATPDMMAQVGRLGRVLGPKGLMPNPKTGTVTMDVTKAVSESKAGKVTYRTDRDGNVHVPVGKVSFDAAKLVENLKTIEEVVTKARPASVRGTYVTHVSIASTFGPSVNVELASF
>NZ_AP014680.1|WP_041094320.1|1720526_1721714_-|ABC-transporter-substrate-binding-protein
MKKFMKVATIMMAMGTIGSTLAGCSASAKSEGNDPGKTIKIGVNMELSGSAGAYGQAEKQGIALAAQEINKAGGIKVGNTKKKIQMIYRDNKTSSSESSSVAAQLVNNDKVQAVVGPATTNAGTAAIPNITKAKVAAISPSASDYSYTLQKDGKVQPYVFRTEYQNNFQGKVVSNFMSKNLKTKRVVIMADKSTDYGTGLAKEFKKDYPGTIVKTVYFQAGDKDFNATLTSIKSKNYDAIFAPGYYSEVGLIVKQARQMGITKPIVGTDGMADPKLTQIAGNSNATNVYYTTPFSTTAAASDKKASAFIKAFKAKYHEDAPTFSALGYDTVYMVKKAIETQKSANSVQIAKGMAKIKDFHGVSGTITIDKKHNPQKTIAIEQLTNGKVAKAFTVK
>NZ_AP014680.1|WP_041094321.1|1722098_1722572_-|glutathione-peroxidase
MSIYDYDVTLEDGTTYSMGKYQGKPLVIVNTATKCGFAPQFKQLEELYKKYQNQGLVVLGFPSSQFKQELSSGEAAAQSCRTTYGVSFPMHTINDVNGKKALPLFDFLTQQAPGAIGSGIKWNFTKFLVDRDGNVIRRYAPKTNPLKMVDEIEKIID
>NZ_AP014680.1|WP_041094322.1|1722717_1723626_-|glycine/betaine-ABC-transporter
MTRKLKTLMVGLSLFLLAIGLSACSSKPAAYNPHKKLGPQINYTITGIDAGAGEMGAAQKALTAYGLKSKNWQLQTSSTAAMTSTLDKAIKNHQAIVITAWEPHWMFTKYPIKFLKDPKNVFGKTENLHTIARTGFKQSNPGAYKLLSQFHWDKTQMSEIMLKVNDGVDPAKAAKNYMKKHPKQVAAWLKGVPNGHGKKVKLTYVAWDSEIASTNLVKQLLDKKGYDTTIQPLEAQPMWASIATGAADASVSAWLPTTHGLYARQYKGEFVDVRVNLKGAKTGLAVPKYMKNINSIEDLKSK
>NZ_AP014680.1|WP_041094323.1|1723628_1724477_-|proline/glycine-betaine-ABC-transporter-permease
MLVLISKLPLADWVNSFVAWLTQFTGFFNGITNFIGGIVNGFQWLFDLLPVWLFIVIVLAITYYATRHGKKWGLLSFELIGLLLIWNLDYWRDMTQTLTLVLTSSLIALVIGIPLGILMAKSHSFEAIMKPILDFMQTMPAFVYLIPAVAFFGIGMVPGVISSVIFAMPPTVRMTNLGIRQVPVELIEAADSYGSTSWQKLVKVQLPLAKSTLMAGVNQSMMLSLSMVVIASMIGALGLGTQVYFAVGRNNAGNGFTAGLAIVILAIILDRITQAFNRSKRG
>NZ_AP014680.1|WP_041094324.1|1724476_1725670_-|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein
MVKKVEVKNLTKIYGKRVPRVKELIEQGKSKAEVLEETGATVGVNQASFSVNEGEIFVIMGLSGSGKSTLIRMINRLIEPTKGTILIDNQDLMKLDKKGLREVRRQKMSMIFQNFALFPNRTIIENTAYGLEIKGITKAVRDQKAHEALELVGLHGYDDQYPSQLSGGMQQRVGLARGLANDAEILLMDEAFSALDPLNRKDMQDELLDLQAKMHKTIIFISHDLNEALRIGDRIMIMKDGVIVQTGTPEDILTRPADDYVKRFIEDVDRTRVLTVANVMIRPNTVNIDKDGPRLAIRRMQENEISSVYVVDNDRKFVGFADAKDIIELIHQGSRDLKSVVQTSVPITHPNVPVNDLMDKLSSTPIPYAVLDDDQHLVGIIVRGAVLGAIAGNEVAQ
>NZ_AP014680.1|WP_041094325.1|1726296_1727451_+|cation:proton-antiporter
MHAIGELCLILIATTIAGHYSARIGLPAVVGQLLVGILVGPAIFDWIKGDEFTSLFSEIGVIILMFSAGMESDLNLLKKYLKPSILVALLGVILPVITIYGLSLAFHLHQTESIFIGVIFAATSVSISVAVLKELDVLHGKAGATILGAAVVDDVLAVVILSVMVSLIGTGASTGGSSNLLLSFTSQIIFFIAIYFVVKFIAPILARLGKHLFIPGGPTIVAVILCLGMALIADAIDLSSVVGAFFAGIAISQTSVKHEVEQNIEPIGYAMFIPVFFVSIGLSMSFDGFMDDFLFIVLLTILATITKLLGAGLGAKLSNFSMKDSYIVGAGMVSRGEMALIIAQIGYRAELLSSEYYSAIITAIILTTLIAPLLLKHAYSLKEN
>NZ_AP014680.1|WP_041094326.1|1727508_1728615_-|NAD(P)-dependent-alcohol-dehydrogenase
MKIKAAVAHDFNQPIAIEDVELDEPKNDEVLVKMVATGMCHADIIATKFQMVPLPAVLGHEGAGIVEKIGPGVTNVAVGDHVILTVASCGECDLCLSGHPAECRRVNELNFGGAYQDGTKRLHQGDQDLSNYFGQGSFATHAIVNKRSAIKIDPELDLKWYGPLGCGFNTGAGAVMNVFKPSIGDSLAVFGTGAVGLAAIMAAKMLNIDKIIAIDIHDNRLKLAKELGATDVINSSQLAKAGDVADAIKAITAGRGVNFSLDTTGISMVTHASIMALDIMGTAGVIAATQDLSFNFTADMLSDNRKLIAITQGDSIPQLFLPQLIAAQQKGLFPFEKLVKFYPLSEINQAMDDSLSGSTIKPILLIDE
>NZ_AP014680.1|WP_041094327.1|1728636_1729497_-|NmrA-family-NAD(P)-binding-protein
MILVTSANGHTGQSIIKQLVKQGYEVRATDIAQSTTDLKQKLGVKEVLVGDLTNINIIREAVKGVDQIVYIPPLFIAEEALVGKYLVDEGIKQHINQFVMISVTHPIMSTLLQHTAKREVEEYLAYQELKNHFNYTVLQPMHYMHNFDPSAVHAQGAYSIFYDINTRLSYVDSDDVGEITGKVLADPVKHTLATYELVGPDFLSPNELVDQYNELTGEHAVAKRVDNLNDFMDTVGFLNVYSREAVTHLADTYSKWGLAGNPNVLTWLLGRQPTTFKQYLQKNIAE
>NZ_AP014680.1|WP_052467350.1|1729863_1730304_-|MarR-family-transcriptional-regulator
MDNVNMWLAVAAKYAGISIDRKLKPEGLGASLYYFILKIHDHDGISQLELGEYIYLDQSGIARGIQQLVELGYVDKIRNQKDKRTSNLYLTQAGKDIYSQIYDKVNQQNELLIKNVPVEQREQFEQNLQIVGQTIFNELQPGKSGK
>NZ_AP014680.1|WP_041094328.1|1730377_1730746_-|iron-chaperone
MDTFAAFIEPIENPKQRARVIKVLQWVMDTFPQLKPRLAWNQPMFTDHGTFIIGFSISKKHMAATPEEAGIAHFTKEIEAAGIDHTKGIIRMPWNQPINYEILQKMIAFNIQDKAQLDKFWR

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP014680_5	5.1\|886845\|25\|NZ_AP014680\|CRISPRCasFinder	886845-886869	25	NZ_CP030863	Streptomyces globosus strain LZH-48 plasmid unnamed1, complete sequence	17171-17195	5	0.8

1. spacer 5.1|886845|25|NZ_AP014680|CRISPRCasFinder matches to NZ_CP030863 (Streptomyces globosus strain LZH-48 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.8

tcatatgagtcctcaaggggcgatc	CRISPR spacer
acatatgagtccttaaggggcgtat	Protospacer
 ************.********  .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

115612 : 142582

Listeria_phage(16.67%)

integrase,transposase

attL 116529:116543|attR 142275:142289

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041092103.1\|115612_116530_+\|integrase	site-specific integrase	A8ATM2	Listeria_phage	7.2e-72	44.2
116529:116543	attL	NA	NA	NA	NA
WP_157869559.1\|116545_117820_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_052467229.1\|117746_118322_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_041092105.1\|118381_119305_+	restriction endonuclease	NA	NA	NA	NA
WP_052467230.1\|119336_119864_+	plasmid pRiA4b ORF-3 family protein	NA	NA	NA	NA
WP_082232230.1\|120112_121321_+	DNA/RNA non-specific endonuclease	NA	NA	NA	NA
WP_052467231.1\|121363_122134_-	ion transporter	A0A1B0Y2S3	Lactobacillus_phage	2.0e-38	51.0
WP_156406629.1\|122250_122427_+	hypothetical protein	NA	NA	NA	NA
WP_041092109.1\|122416_122770_+	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_041095116.1\|122859_124374_+\|transposase	IS66 family transposase	NA	NA	NA	NA
WP_041092111.1\|124667_125852_+	tetracycline resistance MFS efflux pump	A0A2H4UVM2	Bodo_saltans_virus	1.4e-06	27.6
WP_041092113.1\|126026_127175_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_041092116.1\|127482_128838_+\|transposase	IS4-like element ISLho3 family transposase	NA	NA	NA	NA
WP_041092118.1\|128937_130488_+	NgoFVII family restriction endonuclease	NA	NA	NA	NA
WP_041092120.1\|130496_131174_+	hypothetical protein	NA	NA	NA	NA
WP_041092122.1\|131591_132785_+	NAD-dependent formate dehydrogenase	A0A1V0SBV6	Catovirus	1.3e-17	28.5
WP_041092124.1\|133077_134556_-	multidrug efflux MFS transporter	NA	NA	NA	NA
WP_041092126.1\|134686_135295_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_041092128.1\|135391_136429_-	aldehyde reductase	NA	NA	NA	NA
WP_041092130.1\|136536_136983_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_041092131.1\|137264_137621_-	hypothetical protein	NA	NA	NA	NA
WP_041092133.1\|137795_138719_+	EamA family transporter	NA	NA	NA	NA
WP_041092135.1\|138806_139364_-	M15 family metallopeptidase	NA	NA	NA	NA
WP_041092137.1\|139375_139882_-	methylated-DNA--[protein]-cysteine S-methyltransferase	A0A2P1EL10	Moumouvirus	1.6e-17	39.5
WP_082232232.1\|140422_140926_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_041092141.1\|140932_141172_-	hypothetical protein	NA	NA	NA	NA
WP_082232234.1\|141806_142244_-\|transposase	transposase	A0A1S5SBP9	Streptococcus_phage	1.1e-06	31.5
WP_082232236.1\|142225_142582_-\|transposase	transposase	NA	NA	NA	NA
142275:142289	attR	NA	NA	NA	NA

DBSCAN-SWA_2

208366 : 239638

Lactobacillus_phage(37.5%)

tRNA,holin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041092247.1\|208366_209611_-\|transposase	transposase	NA	NA	NA	NA
WP_041092249.1\|210144_211497_+	amino acid permease	NA	NA	NA	NA
WP_041092251.1\|211618_212707_+	aspartate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_041091960.1\|212888_214253_+\|transposase	ISLre2-like element ISLho1 family transposase	NA	NA	NA	NA
WP_156406659.1\|214514_214658_-\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_041092253.1\|215201_217004_+\|tRNA	threonine--tRNA ligase	A0A1V0SKZ9	Klosneuvirus	3.8e-64	33.4
WP_041092255.1\|217465_218503_+	lactonase family protein	NA	NA	NA	NA
WP_041092256.1\|219297_220494_+	ATP-binding protein	NA	NA	NA	NA
WP_041092258.1\|220803_221631_-	DUF368 domain-containing protein	NA	NA	NA	NA
WP_041092260.1\|222144_223509_+\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_041092262.1\|223984_225244_+	nucleoside permease	NA	NA	NA	NA
WP_041092263.1\|225358_226279_+	ribonucleoside hydrolase RihC	NA	NA	NA	NA
WP_041092266.1\|226856_227582_+	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	NA	NA	NA	NA
WP_041092268.1\|227736_228603_+	nucleoid occlusion protein	A0A1C9EHY8	Gordonia_phage	1.3e-09	29.1
WP_041092271.1\|228620_229388_+	ParA family protein	Q8JL10	Natrialba_phage	1.4e-28	30.6
WP_041092273.1\|229377_230259_+	ParB/RepB/Spo0J family partition protein	I3NLC2	Bifidobacterium_phage	1.4e-16	32.8
WP_041092275.1\|230303_230495_+	DUF951 domain-containing protein	NA	NA	NA	NA
WP_041092277.1\|230809_231910_+	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_041092280.1\|231939_232710_+	DUF1129 domain-containing protein	NA	NA	NA	NA
WP_041092282.1\|232850_233408_+	hypothetical protein	A0A2D1GPG5	Lactobacillus_phage	7.6e-08	27.5
WP_041092285.1\|233457_233694_+	hypothetical protein	NA	NA	NA	NA
WP_041092287.1\|233705_234119_+	protein-export chaperone SecB	NA	NA	NA	NA
WP_041092290.1\|234269_235412_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	1.1e-61	32.4
WP_041092292.1\|235632_237036_+	KxYKxGKxW signal peptide domain-containing protein	NA	NA	NA	NA
WP_041092294.1\|237462_238389_+	KxYKxGKxW signal peptide domain-containing protein	NA	NA	NA	NA
WP_041092296.1\|238490_239333_-\|transposase	IS3 family transposase	Q6J1X2	Lactobacillus_phage	1.3e-155	98.6
WP_002816285.1\|239386_239638_-\|transposase	IS3 family transposase	Q6J1X3	Lactobacillus_phage	9.2e-38	96.4

DBSCAN-SWA_3

714499 : 763287

Enterococcus_phage(22.22%)

bacteriocin,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041092043.1\|714499_715912_+\|transposase	IS5-like element ISLho2 family transposase	NA	NA	NA	NA
WP_041093047.1\|715981_718225_-\|protease	ATP-dependent Clp protease ATP-binding subunit	A0A223W0B1	Agrobacterium_phage	6.6e-127	40.7
WP_041093049.1\|718522_718708_+	hypothetical protein	NA	NA	NA	NA
WP_041093050.1\|718891_719158_+	phosphocarrier protein HPr	NA	NA	NA	NA
WP_041093052.1\|719157_720879_+	phosphoenolpyruvate--protein phosphotransferase	NA	NA	NA	NA
WP_041093054.1\|721217_722420_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_041093056.1\|722423_723446_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_041093058.1\|723448_724459_+	flippase-like domain-containing protein	NA	NA	NA	NA
WP_156406656.1\|724628_725819_-	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_041093061.1\|725926_726175_+	YkuJ family protein	NA	NA	NA	NA
WP_052467275.1\|732816_734334_-\|transposase	IS66 family transposase	S5VLC8	Leptospira_phage	3.5e-23	26.0
WP_041095214.1\|734427_734775_-	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_156406640.1\|734776_734953_-	hypothetical protein	NA	NA	NA	NA
WP_041093063.1\|735111_737103_+	sodium:proton antiporter	NA	NA	NA	NA
WP_041093065.1\|737594_739808_+	anaerobic ribonucleoside-triphosphate reductase	A0A0C5KKX3	Enterococcus_phage	2.8e-247	58.1
WP_041093067.1\|739749_740331_+	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A288TZV3	Enterococcus_phage	6.4e-50	56.9
WP_041093068.1\|740353_741109_+	Fe-S cluster assembly ATPase SufC	A0A285PWH2	Cedratvirus	5.1e-07	26.1
WP_052467276.1\|741108_742272_+	SufD family Fe-S cluster assembly protein	NA	NA	NA	NA
WP_041093070.1\|742283_743489_+	SufS family cysteine desulfurase	Q2XUY6	environmental_halophage	1.6e-90	42.4
WP_041093072.1\|743481_743913_+	SUF system NifU family Fe-S cluster assembly protein	NA	NA	NA	NA
WP_041093074.1\|743912_745322_+	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
WP_041093075.1\|745590_746940_+	guanine deaminase	NA	NA	NA	NA
WP_041093077.1\|746951_748292_+	purine/pyrimidine permease	Q9KX94	Enterobacteria_phage	1.8e-18	28.0
WP_041093079.1\|748596_749310_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_041093081.1\|749648_750164_-	acyl-CoA thioesterase	NA	NA	NA	NA
WP_041093083.1\|750387_751578_+	ATP-binding protein	NA	NA	NA	NA
WP_041093085.1\|751673_753014_-	amino acid permease	NA	NA	NA	NA
WP_041093088.1\|753491_754613_+	vitamin B12 independent methionine synthase	A0A218MNE0	uncultured_virus	2.9e-83	44.7
WP_041093090.1\|756653_757838_+	PLP-dependent aminotransferase family protein	NA	NA	NA	NA
WP_041093092.1\|758507_759263_+	hypothetical protein	NA	NA	NA	NA
WP_041093093.1\|759259_759949_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.7e-29	37.9
WP_041093095.1\|759945_761112_+	ABC transporter permease	NA	NA	NA	NA
WP_041093097.1\|761162_761354_+	hypothetical protein	NA	NA	NA	NA
WP_041093098.1\|761463_762165_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_156406639.1\|762340_762496_+\|bacteriocin	bacteriocin	NA	NA	NA	NA
WP_041093100.1\|762510_762693_+	hypothetical protein	NA	NA	NA	NA
WP_082232286.1\|763164_763287_+\|bacteriocin	bacteriocin	NA	NA	NA	NA

DBSCAN-SWA_4

938297 : 1019210

104

Lactobacillus_phage(46.34%)

tail,tRNA,holin,capsid,head,integrase,portal,protease,terminase

attL 950208:950223|attR 996945:996960

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041093345.1\|938297_939344_+\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2H4UW22	Bodo_saltans_virus	3.4e-25	36.0
WP_041093347.1\|939356_941774_+\|tRNA	phenylalanine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_041093349.1\|941914_943033_+	endolytic transglycosylase MltG	NA	NA	NA	NA
WP_041095252.1\|943050_943722_+	uridine kinase	A0A1V0SAA3	Catovirus	4.8e-33	37.6
WP_041093356.1\|943844_944321_+	transcription elongation factor GreA	NA	NA	NA	NA
WP_041093358.1\|944451_944757_+	iron-sulfur cluster biosynthesis protein	NA	NA	NA	NA
WP_041093360.1\|944818_947467_-	YfhO family protein	NA	NA	NA	NA
WP_041093362.1\|947634_949698_+	penicillin-binding protein 2	NA	NA	NA	NA
WP_081721478.1\|949824_949974_+	50S ribosomal protein L33	NA	NA	NA	NA
WP_041093364.1\|950117_950681_+	5-formyltetrahydrofolate cyclo-ligase	NA	NA	NA	NA
950208:950223	attL	NA	NA	NA	NA
WP_082232422.1\|950755_951349_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_041093366.1\|951364_951580_+	YqgQ family protein	NA	NA	NA	NA
WP_041093367.1\|951600_952569_+	ROK family glucokinase	NA	NA	NA	NA
WP_041093369.1\|952587_953001_+	rhodanese-like domain-containing protein	NA	NA	NA	NA
WP_041093371.1\|953067_953244_-	DUF3042 family protein	NA	NA	NA	NA
WP_041093372.1\|953330_954248_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_041093373.1\|954350_954737_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_041093374.1\|954767_956108_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_041093376.1\|956435_957317_+	hypothetical protein	NA	NA	NA	NA
WP_052467293.1\|957309_958251_+	hypothetical protein	NA	NA	NA	NA
WP_041093378.1\|958264_958804_+	dUTP diphosphatase	NA	NA	NA	NA
WP_041093379.1\|959462_960596_-\|integrase	site-specific integrase	A0A2H4J2K7	uncultured_Caudovirales_phage	3.9e-27	28.6
WP_041093380.1\|960828_961401_-	DUF5067 domain-containing protein	Q6SEF8	Lactobacillus_prophage	4.4e-43	62.1
WP_041093382.1\|961457_961715_-	hypothetical protein	NA	NA	NA	NA
WP_041093383.1\|961802_962519_-	hypothetical protein	NA	NA	NA	NA
WP_041093385.1\|962578_963034_-	hypothetical protein	A0A2H4IYT4	uncultured_Caudovirales_phage	1.3e-16	33.3
WP_082232308.1\|963043_963388_-	helix-turn-helix transcriptional regulator	Q4ZB06	Staphylococcus_virus	2.4e-20	67.6
WP_041093386.1\|963547_963739_+	helix-turn-helix transcriptional regulator	D2KRD7	Lactobacillus_phage	7.5e-16	62.9
WP_157869568.1\|963775_963931_+	hypothetical protein	NA	NA	NA	NA
WP_041093388.1\|963981_964695_+	phage antirepressor KilAC domain-containing protein	B4XYR8	Lactobacillus_phage	4.5e-69	59.9
WP_041093390.1\|964704_965004_+	hypothetical protein	NA	NA	NA	NA
WP_156406665.1\|965156_965348_+	hypothetical protein	A0A182BQC3	Lactococcus_phage	1.3e-12	58.1
WP_041093394.1\|965325_965823_-	hypothetical protein	NA	NA	NA	NA
WP_041093396.1\|966006_966210_+	hypothetical protein	NA	NA	NA	NA
WP_041093398.1\|966210_966414_+	hypothetical protein	NA	NA	NA	NA
WP_082232310.1\|967251_968151_+	PD-(D/E)XK nuclease-like domain-containing protein	E9LUM4	Lactobacillus_phage	4.4e-74	48.9
WP_041093399.1\|968154_968601_+	single-stranded DNA-binding protein	A0A2D1GPB7	Lactobacillus_phage	3.8e-42	58.0
WP_052467294.1\|968616_969498_+	DnaD domain protein	A8YQM0	Lactobacillus_phage	5.2e-27	40.6
WP_041093401.1\|969494_969773_+	hypothetical protein	NA	NA	NA	NA
WP_156406661.1\|969756_969897_+	hypothetical protein	NA	NA	NA	NA
WP_041093402.1\|969900_970080_+	hypothetical protein	NA	NA	NA	NA
WP_052467295.1\|970080_970491_+	hypothetical protein	C1KFD0	Lactobacillus_virus	9.9e-05	45.2
WP_041093404.1\|970491_970782_+	hypothetical protein	NA	NA	NA	NA
WP_162182085.1\|971029_971167_+	hypothetical protein	A0A2D1GPI6	Lactobacillus_phage	2.3e-11	68.9
WP_041093408.1\|971156_971540_+	phage protein	Q8LTB5	Lactobacillus_phage	1.4e-29	53.7
WP_041093410.1\|971536_971929_+	hypothetical protein	A0A2I7RP21	Vibrio_phage	1.2e-12	34.4
WP_041093411.1\|971925_972138_+	hypothetical protein	NA	NA	NA	NA
WP_157869569.1\|972178_972346_+	hypothetical protein	NA	NA	NA	NA
WP_156406667.1\|972329_972503_+	hypothetical protein	NA	NA	NA	NA
WP_052467296.1\|972504_972960_+	RusA family crossover junction endodeoxyribonuclease	A8YQM5	Lactobacillus_phage	3.4e-30	51.1
WP_041093414.1\|972959_973205_+	hypothetical protein	NA	NA	NA	NA
WP_041093416.1\|973294_973741_+	hypothetical protein	A0A0P0IZR0	Lactobacillus_phage	1.4e-20	38.8
WP_082232426.1\|974069_974354_+	HNH endonuclease	A0A2P0ZLC6	Lactobacillus_phage	3.2e-34	71.1
WP_041093417.1\|974365_974545_+	hypothetical protein	NA	NA	NA	NA
WP_137597130.1\|974663_974984_+\|terminase	P27 family phage terminase small subunit	A0A2H4JBX8	uncultured_Caudovirales_phage	3.2e-11	42.3
WP_041093419.1\|974980_976663_+\|terminase	terminase large subunit	A0A2P0ZLE5	Lactobacillus_phage	3.6e-202	60.5
WP_041093421.1\|976681_977830_+\|portal	phage portal protein	A0A2P0ZLC9	Lactobacillus_phage	9.0e-112	52.7
WP_041093423.1\|977816_978584_+\|protease	Clp protease ClpP	A0A290FZN4	Caldibacillus_phage	2.6e-51	52.7
WP_041093426.1\|978609_979800_+\|capsid	phage major capsid protein	A0A2P0ZLD6	Lactobacillus_phage	7.3e-157	71.8
WP_041093429.1\|979827_980034_+	hypothetical protein	NA	NA	NA	NA
WP_041093432.1\|980045_980351_+\|head,tail	phage head-tail connector protein	A8ATA0	Listeria_phage	4.5e-10	40.7
WP_082232428.1\|980313_980733_+	hypothetical protein	A8ATA1	Listeria_phage	7.5e-24	47.5
WP_041093436.1\|980729_981137_+	hypothetical protein	A0A2P0ZLD7	Lactobacillus_phage	4.1e-35	57.0
WP_052467297.1\|981543_982155_+	hypothetical protein	A0A2P0ZLF5	Lactobacillus_phage	2.7e-46	48.5
WP_052467298.1\|982226_982541_+	hypothetical protein	NA	NA	NA	NA
WP_156406626.1\|982576_982738_+	hypothetical protein	NA	NA	NA	NA
WP_052467299.1\|982771_987286_+\|tail	phage tail tape measure protein	A0A2P0ZLF1	Lactobacillus_phage	2.3e-09	34.4
WP_041093438.1\|987282_989817_+\|tail	phage tail family protein	Q9AZL3	Lactococcus_phage	1.8e-11	24.7
WP_052467300.1\|989834_993395_+\|tail	phage tail protein	A0A2P0ZL78	Lactobacillus_phage	2.5e-51	74.5
WP_041093439.1\|993417_993843_+	DUF1617 family protein	A0A2H4PB97	Lactobacillus_phage	1.6e-05	25.9
WP_041093440.1\|993844_994108_+	hypothetical protein	NA	NA	NA	NA
WP_041093441.1\|994242_994692_+	hypothetical protein	NA	NA	NA	NA
WP_041093442.1\|994681_994987_+	hypothetical protein	NA	NA	NA	NA
WP_041093443.1\|994983_995241_+\|holin	phage holin	A0A0N7IR91	Lactobacillus_phage	2.1e-21	64.5
WP_052467301.1\|995240_996089_+	N-acetylmuramoyl-L-alanine amidase	A0A1W6JN27	Lactococcus_phage	5.9e-44	51.3
WP_041093444.1\|996302_996581_+	hypothetical protein	NA	NA	NA	NA
WP_041093445.1\|996582_997053_+	hypothetical protein	NA	NA	NA	NA
996945:996960	attR	NA	NA	NA	NA
WP_052467302.1\|997045_997495_+	AP2 domain-containing protein	A3F671	Streptococcus_phage	6.6e-18	33.5
WP_052467303.1\|997495_997870_+	hypothetical protein	NA	NA	NA	NA
WP_041093446.1\|998315_998957_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_041093447.1\|999106_999415_+	50S ribosomal protein L21	NA	NA	NA	NA
WP_041093448.1\|999430_999757_+\|protease	ribosomal-processing cysteine protease Prp	NA	NA	NA	NA
WP_041093449.1\|999783_1000065_+	50S ribosomal protein L27	NA	NA	NA	NA
WP_041093450.1\|1000133_1001201_+	aminopeptidase P family protein	NA	NA	NA	NA
WP_041093451.1\|1001265_1001826_+	elongation factor P	NA	NA	NA	NA
WP_041093452.1\|1001861_1002296_+	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_041093453.1\|1002292_1002706_+	transcription antitermination factor NusB	NA	NA	NA	NA
WP_041093454.1\|1002826_1003687_+	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase	A0A249XZQ2	Enterococcus_phage	1.6e-33	38.3
WP_041093455.1\|1003679_1005026_+	exodeoxyribonuclease VII large subunit	A0A160DEV2	Gordonia_phage	9.4e-28	29.3
WP_041093456.1\|1005028_1005280_+	exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
WP_041093457.1\|1005272_1006148_+	polyprenyl synthetase family protein	NA	NA	NA	NA
WP_041093458.1\|1006166_1006982_+	TlyA family RNA methyltransferase	NA	NA	NA	NA
WP_041093459.1\|1007072_1007528_+	arginine repressor	NA	NA	NA	NA
WP_041093460.1\|1007613_1009296_+	DNA repair protein RecN	NA	NA	NA	NA
WP_041093461.1\|1009494_1010727_+	ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	6.2e-18	52.3
WP_041093462.1\|1010719_1011349_+	ABC transporter permease	NA	NA	NA	NA
WP_041093463.1\|1011365_1012298_+	osmoprotectant ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_041093464.1\|1012297_1012960_+	ABC transporter permease	NA	NA	NA	NA
WP_041093465.1\|1013031_1013367_-	hypothetical protein	NA	NA	NA	NA
WP_041093466.1\|1013547_1014168_+	guanylate kinase	K4JYM5	Abalone_herpesvirus	7.9e-22	32.2
WP_041093467.1\|1014164_1014380_+	DNA-directed RNA polymerase subunit omega	NA	NA	NA	NA
WP_041093468.1\|1014589_1015789_+	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	Q9HH70	Methanothermobacter_phage	2.4e-43	33.3
WP_041093469.1\|1015811_1018226_+	primosomal protein N'	NA	NA	NA	NA
WP_041093470.1\|1018259_1019210_+\|tRNA	methionyl-tRNA formyltransferase	E3SNR5	Prochlorococcus_phage	6.3e-10	30.3

DBSCAN-SWA_5

1074544 : 1083164

Synechococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041093517.1\|1074544_1075027_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	1.3e-16	37.6
WP_041093518.1\|1075010_1076147_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_041093519.1\|1076152_1076887_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3FUQ7	Synechococcus_phage	3.1e-41	40.4
WP_041093520.1\|1076873_1077140_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_041093521.1\|1077143_1077809_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_052467388.1\|1077885_1080048_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.7e-141	39.8
WP_041093523.1\|1080032_1081499_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	6.4e-54	33.1
WP_041093524.1\|1081537_1082590_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	5.2e-58	41.1
WP_041093525.1\|1082582_1083164_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.0e-22	36.9

DBSCAN-SWA_6

1361294 : 1459147

115

Lactobacillus_phage(50.0%)

tail,tRNA,holin,capsid,head,integrase,portal,terminase,transposase

attL 1400336:1400357|attR 1437663:1437684

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041093866.1\|1361294_1362428_-\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_041093868.1\|1362583_1362925_-	DUF1831 domain-containing protein	NA	NA	NA	NA
WP_041093870.1\|1362926_1364090_-	cysteine desulfurase	NA	NA	NA	NA
WP_041093872.1\|1364105_1364801_-	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	NA	NA	NA	NA
WP_041093874.1\|1364830_1365148_-	hypothetical protein	NA	NA	NA	NA
WP_041093876.1\|1365148_1365703_-	NUDIX hydrolase	Q5ULM8	Lactobacillus_virus	1.8e-09	28.5
WP_041093877.1\|1365705_1365924_-	cold-shock protein	NA	NA	NA	NA
WP_041093879.1\|1365943_1366933_-	diaminopimelate epimerase	NA	NA	NA	NA
WP_041093881.1\|1367022_1369821_-\|tRNA	isoleucine--tRNA ligase	A0A2I2L3Y0	Orpheovirus	5.2e-89	26.5
WP_041093883.1\|1370141_1370831_-	DivIVA domain-containing protein	NA	NA	NA	NA
WP_041093885.1\|1370845_1371631_-	RNA-binding protein	NA	NA	NA	NA
WP_173406301.1\|1371646_1371922_-	YggT family protein	NA	NA	NA	NA
WP_041093887.1\|1371934_1372357_-	cell division protein SepF	NA	NA	NA	NA
WP_041093889.1\|1372392_1373613_-	cell division protein FtsZ	NA	NA	NA	NA
WP_041093891.1\|1373640_1375047_-	cell division protein FtsA	NA	NA	NA	NA
WP_052467330.1\|1375190_1376045_-	FtsQ-type POTRA domain-containing protein	NA	NA	NA	NA
WP_041093893.1\|1376073_1377174_-	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	NA	NA	NA	NA
WP_041093894.1\|1377173_1378547_-	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	NA	NA	NA	NA
WP_041093896.1\|1378558_1379521_-	phospho-N-acetylmuramoyl-pentapeptide- transferase	NA	NA	NA	NA
WP_041093898.1\|1379545_1381708_-	penicillin-binding protein	NA	NA	NA	NA
WP_041093900.1\|1381707_1382097_-	hypothetical protein	NA	NA	NA	NA
WP_041093902.1\|1382126_1383074_-	16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH	NA	NA	NA	NA
WP_041093904.1\|1383094_1383523_-	division/cell wall cluster transcriptional repressor MraZ	NA	NA	NA	NA
WP_041093906.1\|1383688_1384033_-	DUF3397 family protein	NA	NA	NA	NA
WP_041093908.1\|1384141_1385104_+	magnesium transporter CorA family protein	C1KFH9	Lactobacillus_virus	3.9e-28	31.0
WP_082232334.1\|1385175_1385295_+	DUF4044 domain-containing protein	NA	NA	NA	NA
WP_041093910.1\|1385564_1387856_-	DNA translocase FtsK	A0A218M9A2	Mycobacterium_phage	1.3e-82	46.3
WP_041093911.1\|1387882_1388395_-\|tRNA	tRNA (cytidine(34)-2'-O)-methyltransferase	NA	NA	NA	NA
WP_041095358.1\|1388589_1389438_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_052467392.1\|1389448_1390618_-	AI-2E family transporter	NA	NA	NA	NA
WP_041093913.1\|1390742_1391774_+	lactonase family protein	NA	NA	NA	NA
WP_041093915.1\|1391949_1393296_-	magnesium transporter	NA	NA	NA	NA
WP_041093917.1\|1393310_1394198_-	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_041093919.1\|1394194_1395004_-	NAD kinase	NA	NA	NA	NA
WP_041093921.1\|1395015_1395705_-	GTP pyrophosphokinase family protein	NA	NA	NA	NA
WP_041093923.1\|1395978_1396614_+	DsbA family protein	NA	NA	NA	NA
WP_052467331.1\|1396677_1397715_-	hypothetical protein	NA	NA	NA	NA
WP_041093925.1\|1397798_1399073_-	O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase	A0A0B5JD48	Pandoravirus	2.1e-05	22.1
WP_041093927.1\|1399085_1399937_-	homoserine O-succinyltransferase	NA	NA	NA	NA
1400336:1400357	attL	NA	NA	NA	NA
WP_156406619.1\|1400678_1401260_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_156406620.1\|1401260_1401431_-	hypothetical protein	NA	NA	NA	NA
WP_052467332.1\|1401617_1402649_-	hypothetical protein	A0A2K9VBX9	Lactobacillus_phage	2.3e-21	30.8
WP_156406621.1\|1402661_1403132_-\|holin	phage holin	B4XYQ8	Lactobacillus_phage	7.3e-20	49.1
WP_082232338.1\|1403160_1403265_-	hypothetical protein	NA	NA	NA	NA
WP_041093935.1\|1403254_1403470_-	hypothetical protein	NA	NA	NA	NA
WP_041093937.1\|1403462_1403840_-	hypothetical protein	A0A0P0IV33	Lactobacillus_phage	5.8e-36	60.2
WP_041093939.1\|1404030_1404228_-	XkdX family protein	NA	NA	NA	NA
WP_041093940.1\|1404224_1404557_-	DUF2977 domain-containing protein	Q7M292	Lactobacillus_phage	3.4e-11	47.4
WP_041093942.1\|1404556_1405312_-	hypothetical protein	NA	NA	NA	NA
WP_041093944.1\|1405308_1406772_-	hypothetical protein	A0A2K9VBY4	Lactobacillus_phage	4.9e-46	33.4
WP_041093946.1\|1406771_1407098_-	hypothetical protein	NA	NA	NA	NA
WP_162182090.1\|1407081_1408365_-\|tail	phage tail protein	A0A0M7RDS2	Lactobacillus_phage	8.6e-71	38.3
WP_041093949.1\|1408249_1409089_-\|tail	phage tail family protein	E9LUJ3	Lactobacillus_phage	1.1e-47	39.1
WP_052467333.1\|1409104_1413730_-\|tail	phage tail tape measure protein	Q9AZS0	Lactococcus_phage	2.8e-103	36.2
WP_162182086.1\|1413736_1413910_-	hypothetical protein	Q3L0S5	Lactobacillus_rhamnosus_Lc-Nu-like_prophage	4.4e-07	40.0
WP_052467334.1\|1413933_1414284_-	hypothetical protein	NA	NA	NA	NA
WP_041093951.1\|1414434_1415043_-\|tail	phage tail protein	A0A2I6QQR1	Streptococcus_phage	2.6e-49	53.2
WP_041093953.1\|1415046_1415427_-	DUF806 family protein	A0A2I6QQR0	Streptococcus_phage	3.4e-23	43.1
WP_041093955.1\|1415426_1415849_-	hypothetical protein	Q9MCK1	Streptococcus_virus	1.1e-27	49.6
WP_052467335.1\|1415851_1416229_-\|head	phage head closure protein	B8R652	Lactobacillus_phage	7.4e-15	36.2
WP_041093957.1\|1416209_1416497_-	hypothetical protein	NA	NA	NA	NA
WP_082232342.1\|1416688_1418581_-\|capsid	phage major capsid protein	A0A0M7RF71	Lactobacillus_phage	3.3e-127	47.8
WP_041093959.1\|1418561_1419737_-\|portal	phage portal protein	A0A0M9JJ63	Lactobacillus_phage	4.2e-88	46.2
WP_169790734.1\|1419737_1419914_-	hypothetical protein	NA	NA	NA	NA
WP_156406622.1\|1419923_1421825_-\|terminase	terminase large subunit	B8R649	Lactobacillus_phage	4.1e-210	57.4
WP_041093961.1\|1421824_1422343_-\|terminase	phage terminase small subunit P27 family	A0A286QNN0	Streptococcus_phage	9.9e-18	37.9
WP_041093963.1\|1422465_1422945_-	HNH endonuclease	B8R694	Lactobacillus_phage	1.7e-48	59.2
WP_041093965.1\|1422937_1423213_-	hypothetical protein	NA	NA	NA	NA
WP_041093416.1\|1423427_1423874_-	hypothetical protein	A0A0P0IZR0	Lactobacillus_phage	1.4e-20	38.8
WP_041093414.1\|1423963_1424209_-	hypothetical protein	NA	NA	NA	NA
WP_052467296.1\|1424208_1424664_-	RusA family crossover junction endodeoxyribonuclease	A8YQM5	Lactobacillus_phage	3.4e-30	51.1
WP_156406666.1\|1424665_1424839_-	hypothetical protein	NA	NA	NA	NA
WP_162182091.1\|1424822_1424990_-	hypothetical protein	NA	NA	NA	NA
WP_041093968.1\|1425040_1425244_-	hypothetical protein	NA	NA	NA	NA
WP_041093970.1\|1425240_1425615_-	hypothetical protein	D2IZL0	Enterococcus_phage	1.6e-14	40.8
WP_041093972.1\|1425663_1425855_-	hypothetical protein	NA	NA	NA	NA
WP_041093974.1\|1425851_1426217_-	hypothetical protein	B4XYT7	Lactobacillus_phage	2.7e-22	49.6
WP_156406662.1\|1426220_1426361_-	hypothetical protein	NA	NA	NA	NA
WP_041093975.1\|1426364_1426763_-	hypothetical protein	NA	NA	NA	NA
WP_041093977.1\|1426765_1428004_-	DnaB-like helicase C-terminal domain-containing protein	A8YQM1	Lactobacillus_phage	2.0e-61	35.3
WP_052467336.1\|1428000_1428834_-	conserved phage C-terminal domain-containing protein	A0A0A0RQ10	Bacillus_phage	7.6e-36	57.9
WP_041093979.1\|1428946_1429546_-	DUF669 domain-containing protein	Q9T0Y2	Lactobacillus_phage	7.1e-44	46.7
WP_173406310.1\|1429548_1430268_-	AAA family ATPase	A8YQL5	Lactobacillus_phage	8.7e-81	65.3
WP_041093982.1\|1430268_1430907_-	DUF1351 domain-containing protein	NA	NA	NA	NA
WP_041093984.1\|1430893_1431127_-	hypothetical protein	NA	NA	NA	NA
WP_041093394.1\|1431311_1431809_+	hypothetical protein	NA	NA	NA	NA
WP_156406665.1\|1431786_1431978_-	hypothetical protein	A0A182BQC3	Lactococcus_phage	1.3e-12	58.1
WP_041093986.1\|1432167_1432455_-	hypothetical protein	NA	NA	NA	NA
WP_041093988.1\|1432492_1433206_-	phage antirepressor KilAC domain-containing protein	B4XYR8	Lactobacillus_phage	1.9e-72	62.0
WP_157869568.1\|1433257_1433413_-	hypothetical protein	NA	NA	NA	NA
WP_041093989.1\|1433424_1433607_-	hypothetical protein	NA	NA	NA	NA
WP_041093991.1\|1433882_1434206_+	helix-turn-helix transcriptional regulator	D2IZV9	Enterococcus_phage	1.9e-11	33.6
WP_041093993.1\|1434207_1434612_+	ImmA/IrrE family metallo-endopeptidase	D6PSS8	Lactobacillus_phage	1.1e-21	40.9
WP_041093995.1\|1434709_1435222_+	Ltp family lipoprotein	A0A097BY93	Leuconostoc_phage	2.0e-10	66.4
WP_162182094.1\|1435456_1436116_+	PH domain-containing protein	A0A0F6N4L7	Staphylococcus_phage	1.2e-36	42.4
WP_041093997.1\|1436294_1437464_+\|integrase	tyrosine-type recombinase/integrase	S5MBZ0	Brevibacillus_phage	1.5e-13	23.2
WP_041093999.1\|1437660_1438365_-	adaptor protein MecA	NA	NA	NA	NA
1437663:1437684	attR	NA	NA	NA	NA
WP_041094001.1\|1438501_1438903_-	transcriptional regulator Spx	NA	NA	NA	NA
WP_041094003.1\|1439210_1439951_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_041094006.1\|1440045_1440534_+	hypothetical protein	NA	NA	NA	NA
WP_041094008.1\|1447881_1448247_-	hypothetical protein	NA	NA	NA	NA
WP_082232346.1\|1448438_1449005_+	phosphatidylglycerophosphatase A	G3MBC5	Bacillus_virus	1.8e-36	49.1
WP_041094010.1\|1448970_1449624_+	VTT domain-containing protein	NA	NA	NA	NA
WP_052467337.1\|1449602_1450244_-	TIGR01906 family membrane protein	NA	NA	NA	NA
WP_041094012.1\|1450218_1450998_-	TIGR01457 family HAD-type hydrolase	NA	NA	NA	NA
WP_041094014.1\|1451013_1451658_-	YutD family protein	NA	NA	NA	NA
WP_041094016.1\|1451692_1453072_-	5'-nucleotidase C-terminal domain-containing protein	NA	NA	NA	NA
WP_041094017.1\|1453115_1453724_-	metallophosphoesterase	A0A076G7D9	Bacillus_phage	4.1e-31	36.9
WP_041094019.1\|1453802_1454993_-	acetate kinase	NA	NA	NA	NA
WP_082232438.1\|1455007_1455769_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_041094021.1\|1456088_1456376_-	hypothetical protein	NA	NA	NA	NA
WP_041094023.1\|1456372_1456819_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_041094025.1\|1456815_1457109_-	hypothetical protein	NA	NA	NA	NA
WP_157869575.1\|1457089_1457530_-	type II secretion system protein	NA	NA	NA	NA
WP_041092043.1\|1457734_1459147_+\|transposase	IS5-like element ISLho2 family transposase	NA	NA	NA	NA

DBSCAN-SWA_7

1809244 : 1817083

Streptococcus_phage(83.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041094396.1\|1809244_1810291_+	DNA (cytosine-5-)-methyltransferase	A0A1I9KKE7	Lactobacillus_phage	8.8e-90	48.4
WP_003678268.1\|1810403_1810625_+	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.9e-27	83.6
WP_010581070.1\|1810650_1811154_+	antirestriction protein ArdA	NA	NA	NA	NA
WP_010581389.1\|1811221_1811602_+	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	1.0e-40	65.6
WP_010581390.1\|1811598_1814052_+	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	66.1
WP_010581391.1\|1814052_1816095_+	conjugal transfer protein	A0A1S5SF30	Streptococcus_phage	2.3e-150	51.7
WP_010581392.1\|1816087_1817083_+	lysozyme family protein	A0A1S5SEZ8	Streptococcus_phage	2.5e-102	57.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_AP014681

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3032 : 60932

Staphylococcus_phage(23.53%)

transposase,protease,integrase

attL 2619:2632|attR 14800:14813

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2619:2632	attL	NA	NA	NA	NA
WP_041095592.1\|3032_3620_-\|integrase	site-specific integrase	D2XR58	Bacillus_phage	1.1e-20	33.1
WP_003625288.1\|3723_4002_+	type II toxin-antitoxin system RelB/DinJ family antitoxin	NA	NA	NA	NA
WP_005917927.1\|3991_4294_+	type II toxin-antitoxin system YafQ family toxin	NA	NA	NA	NA
WP_041095608.1\|4552_5785_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_041095610.1\|7108_9223_+\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	1.1e-118	39.0
WP_082232458.1\|10166_10664_-	ApaLI family restriction endonuclease	NA	NA	NA	NA
WP_041095612.1\|10751_11306_-	DUF536 domain-containing protein	NA	NA	NA	NA
WP_041095614.1\|11926_14920_-\|transposase	Tn3 family transposase	A0A125RQ78	Bacillus_phage	3.9e-207	38.8
14800:14813	attR	NA	NA	NA	NA
WP_003582117.1\|15098_15695_+	recombinase family protein	A0A219Y9V9	Aeromonas_phage	3.5e-27	37.4
WP_003582114.1\|15817_16141_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	5.2e-17	42.7
WP_016373382.1\|16192_17923_+	arsenical pump-driving ATPase	NA	NA	NA	NA
WP_041095617.1\|17965_19261_+	arsenic transporter	A0A2H4PQU3	Staphylococcus_phage	1.7e-143	61.9
WP_025013532.1\|19297_19633_+	arsenite efflux transporter metallochaperone ArsD	NA	NA	NA	NA
WP_004563097.1\|19655_20072_+	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	3.9e-33	56.9
WP_041095619.1\|20884_21133_-	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
WP_041095621.1\|21481_21676_+	hypothetical protein	NA	NA	NA	NA
WP_041095623.1\|21653_22127_+	DUF4355 domain-containing protein	NA	NA	NA	NA
WP_041095625.1\|22139_23183_+	hypothetical protein	O03966	Lactobacillus_phage	7.8e-54	43.0
WP_157869582.1\|23221_24008_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_041095629.1\|24339_25509_+	metallophosphoesterase	NA	NA	NA	NA
WP_003679174.1\|26027_26888_-	DegV family protein	A0A0N9SI50	Staphylococcus_phage	1.1e-05	25.2
WP_041095635.1\|26880_27423_-	DUF1836 domain-containing protein	NA	NA	NA	NA
WP_041095637.1\|27640_28696_+	oxidoreductase	NA	NA	NA	NA
WP_082040903.1\|29306_30590_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	3.9e-47	31.5
WP_041095641.1\|31320_31665_-	DUF5388 domain-containing protein	NA	NA	NA	NA
WP_041095643.1\|31657_32467_-	AAA family ATPase	F0PIG8	Enterococcus_phage	6.0e-54	44.2
WP_041095645.1\|33397_33601_+	hypothetical protein	NA	NA	NA	NA
WP_014564139.1\|35363_35645_+	type II toxin-antitoxin system RelB/DinJ family antitoxin	NA	NA	NA	NA
WP_041095650.1\|35634_36141_+	mRNA interferase PemK	NA	NA	NA	NA
WP_015474680.1\|36130_36409_-	hypothetical protein	NA	NA	NA	NA
WP_082232462.1\|36431_36659_-	hypothetical protein	NA	NA	NA	NA
WP_041095659.1\|36911_38975_+	MobA/MobL family protein	NA	NA	NA	NA
WP_082232464.1\|39160_39745_+	hypothetical protein	F2Y1B5	Organic_Lake_phycodnavirus	1.2e-11	27.2
WP_156406647.1\|39734_40577_+	hypothetical protein	A0A1X9I6W8	Streptococcus_phage	5.6e-63	50.6
WP_041095663.1\|41791_42319_-	biotin transporter BioY	NA	NA	NA	NA
WP_041095665.1\|42462_42909_+	3-hydroxyacyl-ACP dehydratase FabZ	NA	NA	NA	NA
WP_041095667.1\|42921_43389_+	winged helix DNA-binding protein	NA	NA	NA	NA
WP_041095669.1\|43399_44377_+	ketoacyl-ACP synthase III	NA	NA	NA	NA
WP_041095671.1\|44402_44648_+	hypothetical protein	NA	NA	NA	NA
WP_041095673.1\|44651_45554_+	ACP S-malonyltransferase	NA	NA	NA	NA
WP_041095675.1\|45560_46280_+	3-oxoacyl-ACP reductase FabG	A0A0M4JSW6	Mollivirus	4.7e-10	27.7
WP_041095677.1\|46289_47510_+	beta-ketoacyl-ACP synthase II	NA	NA	NA	NA
WP_041095678.1\|47512_47938_+	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit	NA	NA	NA	NA
WP_041095680.1\|47939_48356_+	beta-hydroxyacyl-ACP dehydratase	NA	NA	NA	NA
WP_041095682.1\|48361_49735_+	acetyl-CoA carboxylase biotin carboxylase subunit	NA	NA	NA	NA
WP_041095684.1\|49715_50549_+	hypothetical protein	NA	NA	NA	NA
WP_041095686.1\|50549_51320_+	acetyl-CoA carboxylase	NA	NA	NA	NA
WP_041095688.1\|51344_52100_+	enoyl-ACP reductase FabI	NA	NA	NA	NA
WP_041095690.1\|52109_52919_+	biotin--[acetyl-CoA-carboxylase] ligase	NA	NA	NA	NA
WP_003680381.1\|53908_54124_-	CsbD family protein	NA	NA	NA	NA
WP_003681696.1\|54321_54462_-	hypothetical protein	NA	NA	NA	NA
WP_003680323.1\|54473_54725_-	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
WP_041095698.1\|54739_55282_-	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_041095700.1\|55309_55495_-	DUF2273 domain-containing protein	NA	NA	NA	NA
WP_041095702.1\|55506_56067_-	alkaline shock response membrane anchor protein AmaP	NA	NA	NA	NA
WP_041095704.1\|56264_56849_+	recombinase family protein	M9Q1K0	Clostridium_phage	2.7e-19	34.2
WP_002825823.1\|57208_58414_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_024855732.1\|58529_59906_+	FAD-dependent oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	1.3e-11	22.5
WP_155804434.1\|60125_60932_-\|transposase	IS3 family transposase	Q716C2	Shigella_phage	7.2e-15	29.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP014682

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_AP014680

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_AP014681

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection