CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP010525	Bacillus coagulans strain HM-08 chromosome, complete genome	17 crisprs	cas3,cas5,cas8c,cas7,cas4,cas1,cas2,RT,DinG,DEDDh,csa3,casR	4	16	11	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP010525_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_1

28127-28218

Orphan

Consensus_repeat	Method
TCGTAGTGCTTTTTTATTATATGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_1

>merge|NZ_CP010525|1|28127-28218|CRISPRCasFinder
TCGTAGTGCTTTTTTATTATATGGTTCACCTAACCCCCGATTTCGTGCCTGTTCAAGCTATGTAGCCCATCGAGTGCTTTTTTATTATATGG

>NZ_CP010525|1|1|28127-28218|CRISPRCasFinder
TCGTAGTGCTTTTTTATTATATGG	TTCACCTAACCCCCGATTTCGTGCCTGTTCAAGCTATGTAGCCC
ATCGAGTGCTTTTTTATTATATGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_013860883.1\|20738_20978_+\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NZ_CP010525.1\|WP_014096628.1\|28543_29254_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP010525.1\|WP_035183097.1\|35716_36196_+\|23S-rRNA-(pseudouridine(1915)-N(3))-methyltransferase-RlmH	unknown	unknown	gnl\|CDD\|376840
NZ_CP010525.1\|WP_035183101.1\|40283_41663_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP010525.1\|WP_035183099.1\|36522_37980_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_026683520.1\|34155_35418_+\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP010525.1\|WP_035183084.1\|17920_19114_+\|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II	unknown	unknown	gnl\|CDD\|181774
NZ_CP010525.1\|WP_035183096.1\|32345_33128_+\|two-component-system-regulatory-protein-YycI	unknown	unknown	gnl\|CDD\|378229
NZ_CP010525.1\|WP_026683519.1\|33144_33939_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|224156
NZ_CP010525.1\|WP_014096626.1\|24745_26101_+\|replicative-DNA-helicase	unknown	unknown	gnl\|CDD\|180232
NZ_CP010525.1\|WP_157660077.1\|36211_36526_+\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143393
NZ_CP010525.1\|WP_035183090.1\|22112_24086_+\|DHH-family-phosphoesterase	unknown	unknown	gnl\|CDD\|226404
NZ_CP010525.1\|WP_014096625.1\|24082_24526_+\|50S-ribosomal-protein-L9	unknown	unknown	gnl\|CDD\|234659
NZ_CP010525.1\|WP_035183094.1\|31075_32359_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369363
NZ_CP010525.1\|WP_014096627.1\|26275_27565_+\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NZ_CP010525.1\|WP_014096621.1\|19850_20138_+\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NZ_CP010525.1\|WP_142743397.1\|21135_22077_+\|DUF2232-domain-containing-protein	unknown	unknown	gnl\|CDD\|370773
NZ_CP010525.1\|WP_014096620.1\|19126_19597_+\|6,7-dimethyl-8-ribityllumazine-synthase	unknown	unknown	gnl\|CDD\|234606
NZ_CP010525.1\|WP_014096622.1\|20199_20694_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|168659
NZ_CP010525.1\|WP_014096629.1\|29258_31079_+\|cell-wall-metabolism-sensor-histidine-kinase-WalK	unknown	unknown	gnl\|CDD\|380161

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_013860883.1\|20738_20978_+\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	6.9465e-42
NZ_CP010525.1\|WP_014096628.1\|28543_29254_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.68549e-100
NZ_CP010525.1\|WP_035183097.1\|35716_36196_+\|23S-rRNA-(pseudouridine(1915)-N(3))-methyltransferase-RlmH	gnl\|CDD\|376840	pfam02590, SPOUT_MTase, Predicted SPOUT methyltransferase. This family of proteins are predicted to be SPOUT methyltransferases.	3.9983e-88
NZ_CP010525.1\|WP_035183101.1\|40283_41663_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	2.23751e-127
NZ_CP010525.1\|WP_026683520.1\|34155_35418_+\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	6.69913e-92
NZ_CP010525.1\|WP_035183084.1\|17920_19114_+\|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II	gnl\|CDD\|181774	PRK09311, PRK09311, bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II.	0
NZ_CP010525.1\|WP_035183096.1\|32345_33128_+\|two-component-system-regulatory-protein-YycI	gnl\|CDD\|378229	pfam09648, YycI, YycH protein. This domain is exclusively found in YycI proteins in the low GC content Gram positive species. These two domains share the same structural fold with domains two and three of YycH pfam07435. Both, YycH and YycI are always found in pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Lastly, the two proteins always contain an N-terminal transmembrane helix and are localized to the periplasmic space as shown by PhoA fusion studies.	4.11937e-56
NZ_CP010525.1\|WP_026683519.1\|33144_33939_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|224156	COG1235, PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only].	1.30136e-70
NZ_CP010525.1\|WP_014096626.1\|24745_26101_+\|replicative-DNA-helicase	gnl\|CDD\|180232	PRK05748, PRK05748, replicative DNA helicase; Provisional.	0
NZ_CP010525.1\|WP_157660077.1\|36211_36526_+\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	0.00218897
NZ_CP010525.1\|WP_035183090.1\|22112_24086_+\|DHH-family-phosphoesterase	gnl\|CDD\|226404	COG3887, COG3887, Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms].	0
NZ_CP010525.1\|WP_014096625.1\|24082_24526_+\|50S-ribosomal-protein-L9	gnl\|CDD\|234659	PRK00137, rplI, 50S ribosomal protein L9; Reviewed.	9.80627e-66
NZ_CP010525.1\|WP_035183094.1\|31075_32359_+\|hypothetical-protein	gnl\|CDD\|369363	pfam07435, YycH, YycH protein. This family contains the bacterial protein YycH which is approximately 450 residues long. YycH plays a role in signal transduction and is found immediately downstream of the essential histidine kinase YycG. YycG forms a two component system together with its cognate response regulator YycF. PhoA fusion studies have shown that YycH is transported across the cytoplasmic protein. It is postulated that YycH functions as an antagonist to YycG. The molecule is made up of three domains, and has a novel three-dimensional structure. The N-terminal domain features a calcium binding site and the central domain contains two conserved loop regions.	4.96408e-80
NZ_CP010525.1\|WP_014096627.1\|26275_27565_+\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NZ_CP010525.1\|WP_014096621.1\|19850_20138_+\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	1.01619e-40
NZ_CP010525.1\|WP_142743397.1\|21135_22077_+\|DUF2232-domain-containing-protein	gnl\|CDD\|370773	pfam09991, DUF2232, Predicted membrane protein (DUF2232). This family of bacterial proteins are multi-pass membrane proteins with up to 10 (2 x 4/5) transmembrane regions. The exact function of this potential pore molecule is not known, but in many instances it is associated with ABC-transporter-like domains, implying that it is part of a secretion system that uses energy.	8.61418e-43
NZ_CP010525.1\|WP_014096620.1\|19126_19597_+\|6,7-dimethyl-8-ribityllumazine-synthase	gnl\|CDD\|234606	PRK00061, ribH, 6,7-dimethyl-8-ribityllumazine synthase; Provisional.	6.10782e-87
NZ_CP010525.1\|WP_014096622.1\|20199_20694_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|168659	PRK06751, PRK06751, single-stranded DNA-binding protein; Provisional.	9.81725e-74
NZ_CP010525.1\|WP_014096629.1\|29258_31079_+\|cell-wall-metabolism-sensor-histidine-kinase-WalK	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	0

>NZ_CP010525.1|WP_014096627.1|26275_27565_+|adenylosuccinate-synthase
MSSVVVVGTQWGDEGKGKITDFLSENAEVVSRYQGGNNAGHTIRFNGETYKLHLIPSGIFYKDKICVIGNGVVVDPKALVEELDYLNGRGISTENLRISNRAHVILPYHIKLDGAEEERKGSNKIGTTKKGIGPAYMDKAARTGIRIADLLDYEEFKEKLTRNLEEKNRLFEKIYETEGFTLEEILEPYYEYGQRFKQYVCDTSVVLNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPIAGGVTIGSGVGPSKINHVVGIAKAYTTRVGDGPFPTELLDETGDRIRETGHEYGTTTGRARRVGWFDSVVVRHARRVSGLTDLSVNLLDVLTGIETLKICVAYRYKGKVLEAFPASLKVLAECEPVYEELPGWTEDITGCRSLDELPDNARHYLERISQLTGVPLSMFSVGPDRLQTIVVQSVWRV
>NZ_CP010525.1|WP_014096626.1|24745_26101_+|replicative-DNA-helicase
MNELQDRIPPQNIEAEQAVLGAIFLEPSAFITASEILTAEDFYRNAHQKIFQVFAKLNDAGKAVDLVTVAEELSATRQLEDAGGLSYLSELAASVPTAANIAYYAGIVAEKALLRRLIRTATHIAQEGYTREDDVDELLDEAERSIMEVAQRKNAGDFKHIKDVLVSTYDNIEMLHNRKGDVTGIPTGFYELDRMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVGTKTEENVAIFSLEMGAEQLVMRMLCAEGNIDAQRLRTGALTDEDWRKLTMAMGSLSNSGIYIDDTPGVRVTEIRSKCRRLKQEHGLGMVVIDYLQLIQGSARSRENRQQEVSEISRSLKALARELEVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYREDYYEQDTENKNIIEIIIAKQRNGPVGTVQLAFIKEYNKFVNLERRFDDAPVPA
>NZ_CP010525.1|WP_014096625.1|24082_24526_+|50S-ribosomal-protein-L9
MKVIFLKDVKGKGKKGDIKNVADGYAHNYLFKNGAAIEATPANLKSMEAQKRKEEKLAQEELEEAKKLKEKLENITVEIKAKSGQDGRLFGSVTSKQISEQLKKSFQIQVDKRKIELPDAIRTLGYTKVPVRLHHNVTAVLNVHVSE
>NZ_CP010525.1|WP_035183090.1|22112_24086_+|DHH-family-phosphoesterase
MPSYYNKRFMRYPLYGLIAVSLILLGIIFFYHWWITAAGIVVLGALSYCAFYVEQRSSEEIERYISNLSYRVKRVGEEALMEMPIGIMLYNEDYIIEWTNPFMASCFNEDTLVGRSLYDVAEVLVPLIKQEMHSETISLNERKYRVVLKLEERLLYFFDITEQAEVEQLYEDERTVIAIIYLDNYDEVTQGMDDQSVSSLNSLVTSILNKWTMEFGLFFKRISSDKFIAVFNERILHELEDNKFSILDEVREATAKQNVALTLSIGVGAGVPSLPELGELAQSSLDIALGRGGDQVAIRQANGKVKFYGGKTNPVEKRTRVRARVISHALRELMMERDKVMIMGHKFPDMDAIGAAVGIRKVAEINQKDGYIILNPSETDTSVKRLLGEIKQYPDLYARFITPDEALEMATDDTLLVVVDTHKPSFVIDERIVRRIENVVVIDHHRRGEDFIKNPLLVYMEPYASSTSELVTELMEYQPKNGKINMLEATALLAGIIVDTKSFTLRTGSRTFDAASYLRAQGADTVLVQKFLKEDLRSYIQRAKLVETVKFPLNGIAVAKGKNETIYSPVLMAQAADTILMMNGVDASFVIGRRSENEVGISARSLGSVNVQIIMETLDGGGHLSNAATQMKNITVDEAEEKLIQVIEEYMEGSQQS
>NZ_CP010525.1|WP_142743397.1|21135_22077_+|DUF2232-domain-containing-protein
MKKTRMLTEGAMLAAVFGVMLLVALHVPVIRIIVLVFLPLPFILFCAKYSLRSILVFCLVCLLVSAIMGTVMAIPMAVFFVCIGFVMGYAIQRKKSKLFIYIATSLTFLAITIIGLFATLKFFHLNIIAENLKIMQQSIEQSKALVNSLGESQAYEDRFAQMADAASQMYSVYLPSLLLLSAFIAVFVLISVNFPIAKRFGVPVPSFQPFREMRLPGNILWYFILAMVANLLMHGDTGSFFAKAVLNLMLIFQILILLQGYAFISFVSHEKKWPKGLLAFAVILSIIFSPLLYLVMIFGIMDLGFDFRRMIQK
>NZ_CP010525.1|WP_013860883.1|20738_20978_+|30S-ribosomal-protein-S18
MAGGRRGGRKRRKVCYFTANHITHIDYKDVDLLKKFISERGKILPRRVTGTSAKYQRKLTTAIKRARQMALLPYVAEDK
>NZ_CP010525.1|WP_014096622.1|20199_20694_+|single-stranded-DNA-binding-protein
MLNRVVLVGRLTKDPDLRYTPSGVAVATFTLAVNRTFTNQQGEREADFINCVVWRKQAENVANYLKKGSLAGVDGRIQTRNYEAQDGRRVYVTEVVADSVQFLEPRSANQERGSSQNYGNNQGSAFPGYNQNQNQYQRNDSKPDEDPFSNDGQPIDISDDDLPF
>NZ_CP010525.1|WP_014096621.1|19850_20138_+|30S-ribosomal-protein-S6
MRKYEIMYIIRPNIEDEAKKALVERFDNVLNNQGAEIIESKEWGKRRLAYEIQDFRDGYYHIINVNAEPVAVQEFDRLAKINGDIIRHIVVREEE
>NZ_CP010525.1|WP_014096620.1|19126_19597_+|6,7-dimethyl-8-ribityllumazine-synthase
MGQIFEGNLVGTGLKIGMVAARFNEFITTRLVSGAKDALLRHGVKEEAIDLAWVPGAFEIPLAAKKMAETDKYDAVLALGAVIRGATPHFEYVSAEAAKGVAHASLSTETPVIFGILTTDTIEQAIERAGTKAGNKGWDAAVSAIEMANVIRKIEA
>NZ_CP010525.1|WP_035183084.1|17920_19114_+|bifunctional-3,4-dihydroxy-2-butanone-4-phosphate-synthase/GTP-cyclohydrolase-II
MFHTIEEAVEDLKAGKVVIAVDDENRENEGDFIGLAEKATPEMINLMAKAGRGLICAPITAEKARQLDLYPMARQNTDSHETAFTVSIDHAATRTGISAFERAKTVRHLAEDAVKAEDFHRPGHIFPLVAKAGGVLERSGHTEAAVDLAKLAGANPAGVICEIMNEDGTMARLPQLEEIAKNSGIKLVTIQSLIEYRKKHEKLIQKEAEITLPTRYGTFRAAGYKDLLSGGEHVALIKGEVSSEEPVLARIHSECLTGDCFGSLRCDCGPQLARSLARIEKEGRGVLVYMRQEGRGIGLLNKLKAYRLQEKGLDTVEANRRLGFPADMRDYCIAAQILKDLGATQVRLLTNNPDKVEALTRYGIRIAERVPVEIAPVRENEGYLRTKAEKMGHLLHI
>NZ_CP010525.1|WP_014096628.1|28543_29254_+|response-regulator-transcription-factor
MDKKILVVDDEKPIADILQFNLTKEGYTVYCAYDGEEALEKVEEVQPDLIVLDIMLPKRDGMEVCREVRKKYNMPIIMVTAKDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQTPAAPGEEEESNEIAIGSLVIHPDAYVVSKRGETIELTHREFELLHYLAKHIGQVMTREHLLETVWGYDYYGDVRTVDVTVRRLREKVEDNPSHPEWIVTRRGVGYYLRNPEQE
>NZ_CP010525.1|WP_014096629.1|29258_31079_+|cell-wall-metabolism-sensor-histidine-kinase-WalK
MNKVKFFQSIHFKFVLIYILLIVVAMEIIGVYFINKLENQLETNFKKSIYDQVNVLEYSIEDLLTKKQNQAADITLKVRKVLGDFKSTDVSEIRLIDAHSGVILGTSSNDQSIVGQKTTEDIVKSVRVTGQPEDQIYLDKQTGDRMWVLASPIKANGELIGIIYLVSKIETVYRQVQAINQIFMTGTVIAVLVTALLGIITARTISKPLSEIRKQAMAMARGNFARKVKVIGNDEIGQLAYSFNHMTKKLQEAQASTEGERRKLDSILTHMTDGVIATDRRGRIILINEPAAEMLDVSRETVLSQPLISVLKIENEHKFDDLLTEQDSVILDFSTEEEPYILRANFSVIQNEAGFVSGLITVLHDVTEQEKIDMERREFVANVSHELRTPLTTMRSYLEALTDGAWKDEKIAPQFLGVTQNETERMIRLVNDLLKLSKMDSKDEHLNKEWVNFVEFFHHVIDRFEMAKQQNVTFKRKLPNTEIFVEIDEDKMTQVLYNIISNALKYSPEGGQITFKLRELNEKIEVSISDQGVGIPKENVKKIFERFYRVDKARSRKLGGTGLGLAIAKEMVEMHGGSIWASSKEGKGTTIYFTLPYEPAQEDEWL
>NZ_CP010525.1|WP_035183094.1|31075_32359_+|hypothetical-protein
MSLEKAKTIILTLLVLLSLLLTWLIWNNQPNYDLLNLKDLDNIAIAKEKKVPGIILPDKILYHENDGTTGTVHDGEISRVMNLLRTWTFDMSSSRLLQKKDLYNLMYGKNRIELDFPAPVPFSVYQSVLNFANKKVPDADFDHIVIELNKGTKNLNHVYFISTASNKVYEASTDQKSIQVFISKLNDNKSLYKPYTAFALSGPRRIYLPAGNPVVNQYKYATTDIEIDKFKKALFADPNFVKKVAGEYTNGISLLRTDESNKVLTFVNPGEDIGYSSDPNHLLTRAIDFINQHSGWTDQYQYFEINERENEVTFRLFKDGYPVFNDDGMAEIREYLGKSEIYKYVRPYFNLSLNLPLKPAAVKLPPAQDVIAGLQTNPSVQMNKVRDIAVGYRLQKDSDDILSLQPAWYYCEDGIWKMAGGDEDGLE
>NZ_CP010525.1|WP_035183096.1|32345_33128_+|two-component-system-regulatory-protein-YycI
MDWSKTKTIFILVFLVLDIYLSCQLYFKHVKNQYEVIGSPTAEQSLKAANITFVNLPKGKAKRPYISAEEKVFTAKDLKKLKNQQAEIVNGYQLSSAFDKPVKLGTKIKMDQLEAVIQENMLYGSRYKLWNYDKDLNQAVFYETYNGKMIFNNKNAKLTVYLNDQNEIISYDQTYLTNIKIYREEEETLSAVKAVEALYKKGTLKPNSKVTKAELGYYTRVPELQVLVPTWHFTVKHGNETEQLFINAFEGQVNEMENAQ
>NZ_CP010525.1|WP_026683519.1|33144_33939_+|MBL-fold-metallo-hydrolase
MGMQFSVLASGSTGNAIYVETEQHAFLVDAGLSGRQMEQLFGQIGRNIADLSGILVTHEHSDHIKGIGVLARKYKLPIYANDKTWSAMEGMIGEIPTDLKFSFGMESVQSFGSLEIESFGVSHDAVQPMFYIFHEGSKKLVIITDTGYVSDRMKGTISNADIFVFESNHDVEMLRMGRYPWSVKQRILSDVGHVSNEDAALAMSEVIGDRTKRIYLAHLSKDNNMKDLARMAVSQTLQEQGLAVGETFSLYDTDPKIPTALTAV
>NZ_CP010525.1|WP_026683520.1|34155_35418_+|trypsin-like-peptidase-domain-containing-protein
MGYYDDQDGQRRGKENRRSGGKFGYFLSGLIGVIVGALVVALLFPNIFGKTNSDSSAVDSNSVANTSTSTAKTTKTVSLKVTTDITKAVEKTEKAVVGVSNIQKQSIWSDDMFGQDSKSSSSSSQEAGSGSGIIYKKAGDKAYVVTNYHVIEGANALEVTLSNGKKLSAKLVGGDKYTDLAVLQIDGSNVTTVAQFGDSDALKLGESVIAIGNPLGEEFAGSVTEGIVSGLNRTVPVDIDEDGTEDWQEEVIQTDAAINPGNSGGALINISGQVVGINSMKISNESVEGIGFSIPINSAKPVIHQLETKGKITRPAMGVGIVNVSDISAYQQQETLKLPTNVTTGVVIGSIENGSPAGKAGLKEFDVIYKLDDQKINNTVELRKYLYEHKQPGDKVKVSVYRNGQPKTFTLTLGTASGSN
>NZ_CP010525.1|WP_035183097.1|35716_36196_+|23S-rRNA-(pseudouridine(1915)-N(3))-methyltransferase-RlmH
MNISIVTVGKLKEKYLKQGIQEYLKRLSAYAKVEIIEVADEKASEMLSAAEMELVKQKEGERILAKISPDTYVITLAIDGKMKSSEELADSLDRLATYGKSKIAFVIGGSLGLSQAVLQRGNESLSFSKMTFPHQLMRLILVEQIYRAFRIIRGEPYHK
>NZ_CP010525.1|WP_157660077.1|36211_36526_+|nucleotidyltransferase-domain-containing-protein
MNLNTSIIKNVLKENLYFECRRAFIRGSFARGENTIKSDMDLLIVSNDFNGMAIKKRKEIVKKVFDSSMDNIIDCICLTEAEYNQIIAQKRNLLLKEVLIEVII
>NZ_CP010525.1|WP_035183099.1|36522_37980_+|hypothetical-protein
MKQFFIESFQNILHKYIPYLKRDRLSQNDIKILSEFSFLLLDIISKLEFSSYDKVLLERLLVKYNNLLYSKARIFYYSSFHYLPSKFFDGKPEEISKATFKVNIDINIMRLQIKSGSVTGSSEDEYFFSRGKNDLLRAMKNLVTYGKDENEIFIPAFYTLLNYHQAIMEYLESDNKTYEMEAEKIIEEINSIINLFFKKSSIKNRIEIDYQLKLFLENEVKRYKIWKKENYDYKRINIKGFKVYKNISKKNWAFLSLYNINSEEFCNQFEIDFRNMYENQLDKLKDIEQIILLRNCVNFFFWIKDNKIDKLNIPVFEKFNSNNWFKLSDYFNGYEQINSILVTDEDRKKIESWDDNELRKKVGKTIINIDPNIIAKECSKPHGVYEIADMELPIKNKDNYNTYYLCMPFKSGKEIKGKVKEDLTYQVFRPYTYFGERAIVVFISVKEATEPFYNSIKRAKANLNWEVHTIIGDTLIKLLKYNSLI
>NZ_CP010525.1|WP_035183101.1|40283_41663_-|PLP-dependent-aminotransferase-family-protein
MKNTIFTFNDHSPKYKQIYEKFKSFIEQGDIKPNEPLPSIRQLADSLHVSRNTTLMAYEQLVAEGYIRGESRKGYFVNELEPLFVQEVRIASNPKQTEPESSVCVDFRADAVDQSHFPFKTWRKISNQVLTVKDSFRYGEPFGELCLREQIAAYLLQSRGVRTDPNAIIIGSSTQQMLVYLGHILKDEFQSIIVEDPGYDGAREAFQFHRFTFETLPVYETGADLSKLEQMQSRLIYVTPSHQSPMGVSMSIQQRQMLIHWVNKMRGYIIEDDYDSEFRYTQKPFPALASIDSARVIYLGNFSKSFLPGIRLSYMVLPQPLLDRYQHQFRHFESTTSILSQLAMAKFMEEGEWSRHIKRMRLVYKRKMQHLVSLLRKEFEDTISIIGEQSGLYLLVKVHLNRSEEWLMERAFSYGVKVYPTSCYFVKNNPDKPMIKLGFSNLSFDEIQLGVKLLKKAWL

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Crispr_ID: NZ_CP010525_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_2

119934-120011

Orphan

Consensus_repeat	Method
CCAAATGTCCTTATAACGGGGATGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_2

>merge|NZ_CP010525|2|119934-120011|CRISPRCasFinder
CCAAATGTCCTTATAACGGGGATGAAGGACAAAAGGAGAATCGCCGGCGCCCCAAATGTCCTTCATAACGGGGATGAA

>NZ_CP010525|2|2|119934-120011|CRISPRCasFinder
CCAAATGTCCTTATAACGGGGATGAA	GGACAAAAGGAGAATCGCCGGCGCCC
CAAATGTCCTTCATAACGGGGATGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_035183163.1\|124569_124947_+\|CidA/LrgA-family-holin-like-protein	unknown	unknown	gnl\|CDD\|167253
NZ_CP010525.1\|WP_035183167.1\|127547_128414_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|283645
NZ_CP010525.1\|WP_035183153.1\|112237_114040_+\|carbon-starvation-protein-A	unknown	unknown	gnl\|CDD\|224877
NZ_CP010525.1\|WP_035183151.1\|111390_112107_+\|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|184495
NZ_CP010525.1\|WP_014096678.1\|108556_109399_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NZ_CP010525.1\|WP_035183165.1\|125943_126423_+\|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl\|CDD\|237976
NZ_CP010525.1\|WP_035183161.1\|121529_123377_+\|asparagine-synthase-(glutamine-hydrolyzing)	unknown	unknown	gnl\|CDD\|273676
NZ_CP010525.1\|WP_164931355.1\|126499_126676_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|309474
NZ_CP010525.1\|WP_014096676.1\|106802_107843_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|236863
NZ_CP010525.1\|WP_014096689.1\|123525_124467_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176129
NZ_CP010525.1\|WP_014096682.1\|114379_115453_+\|branched-chain-amino-acid-aminotransferase	unknown	unknown	gnl\|CDD\|237363
NZ_CP010525.1\|WP_164931356.1\|125689_125836_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_014096683.1\|115906_116656_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NZ_CP010525.1\|WP_035183149.1\|109634_111416_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NZ_CP010525.1\|WP_035183170.1\|128669_129518_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP010525.1\|WP_026684575.1\|124936_125620_+\|LrgB-family-protein	unknown	unknown	gnl\|CDD\|377236
NZ_CP010525.1\|WP_014096933.1\|117950_119312_+\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|379252
NZ_CP010525.1\|WP_014096684.1\|116731_117178_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|378960
NZ_CP010525.1\|WP_014096677.1\|107832_108495_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NZ_CP010525.1\|WP_035183159.1\|120162_121176_-\|DUF1646-family-protein	unknown	unknown	gnl\|CDD\|285138

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_035183163.1\|124569_124947_+\|CidA/LrgA-family-holin-like-protein	gnl\|CDD\|167253	PRK01658, PRK01658, CidA/LrgA family holin-like protein.	3.49877e-27
NZ_CP010525.1\|WP_035183167.1\|127547_128414_-\|alpha/beta-hydrolase	gnl\|CDD\|283645	pfam06028, DUF915, Alpha/beta hydrolase of unknown function (DUF915). This family consists of several bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.	5.9114e-70
NZ_CP010525.1\|WP_035183153.1\|112237_114040_+\|carbon-starvation-protein-A	gnl\|CDD\|224877	COG1966, CstA, Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms].	0
NZ_CP010525.1\|WP_035183151.1\|111390_112107_+\|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	gnl\|CDD\|184495	PRK14084, PRK14084, DNA-binding response regulator.	5.3243e-63
NZ_CP010525.1\|WP_014096678.1\|108556_109399_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	9.66105e-109
NZ_CP010525.1\|WP_035183165.1\|125943_126423_+\|Cys-tRNA(Pro)-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	2.42146e-78
NZ_CP010525.1\|WP_035183161.1\|121529_123377_+\|asparagine-synthase-(glutamine-hydrolyzing)	gnl\|CDD\|273676	TIGR01536, Asparagine_synthetase_1, asparagine synthase (glutamine-hydrolyzing). This model describes the glutamine-hydrolysing asparagine synthase. A poorly conserved C-terminal extension was removed from the model. Bacterial members of the family tend to have a long, poorly conserved insert lacking from archaeal and eukaryotic sequences. Multiple isozymes have been demonstrated, such as in Bacillus subtilis. Long-branch members of the phylogenetic tree (which typically were also second or third candidate members from their genomes) were removed from the seed alignment and score below trusted cutoff. [Amino acid biosynthesis, Aspartate family].	0
NZ_CP010525.1\|WP_164931355.1\|126499_126676_+\|hypothetical-protein	gnl\|CDD\|309474	pfam04350, PilO, Pilus assembly protein, PilO. PilO proteins are involved in the assembly of pilin. However, the precise function of this family of proteins is not known.	0.00620974
NZ_CP010525.1\|WP_014096676.1\|106802_107843_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|236863	PRK11153, metN, DL-methionine transporter ATP-binding subunit; Provisional.	0
NZ_CP010525.1\|WP_014096689.1\|123525_124467_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176129	cd08438, PBP2_CidR, The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold. This CD includes the substrate binding domain of CidR which positively up-regulates the expression of cidABC operon in the presence of acetic acid produced by the metabolism of excess glucose. The CidR affects the control of murein hydrolase activity by enhancing cidABC expression in the presence of acetic acid. Thus, up-regulation of cidABC expression results in increased murein hydrolase activity. This substrate binding domain has significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	9.63672e-88
NZ_CP010525.1\|WP_014096682.1\|114379_115453_+\|branched-chain-amino-acid-aminotransferase	gnl\|CDD\|237363	PRK13357, PRK13357, branched-chain amino acid aminotransferase; Provisional.	0
NZ_CP010525.1\|WP_014096683.1\|115906_116656_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	5.933e-84
NZ_CP010525.1\|WP_035183149.1\|109634_111416_+\|sensor-histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	0
NZ_CP010525.1\|WP_035183170.1\|128669_129518_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	8.49466e-81
NZ_CP010525.1\|WP_026684575.1\|124936_125620_+\|LrgB-family-protein	gnl\|CDD\|377236	pfam04172, LrgB, LrgB-like family. The two products of the lrgAB operon are potential membrane proteins, and LrgA and LrgB are both thought to control of murein hydrolase activity and penicillin tolerance.	2.54251e-74
NZ_CP010525.1\|WP_014096933.1\|117950_119312_+\|IS4-family-transposase	gnl\|CDD\|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	4.90454e-20
NZ_CP010525.1\|WP_014096684.1\|116731_117178_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|378960	pfam12821, ThrE_2, Threonine/Serine exporter, ThrE. ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N-terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.	1.33921e-38
NZ_CP010525.1\|WP_014096677.1\|107832_108495_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	1.63809e-93
NZ_CP010525.1\|WP_035183159.1\|120162_121176_-\|DUF1646-family-protein	gnl\|CDD\|285138	pfam07854, DUF1646, Protein of unknown function (DUF1646). Some of the members of this family are hypothetical bacterial and archaeal proteins, but others are annotated as being cation transporters expressed by the archaebacterium Methanosarcina mazei.	3.21322e-97

>NZ_CP010525.1|WP_014096933.1|117950_119312_+|IS4-family-transposase
MIAKNSLNNQLPNEIKSTFKELNVLKHLRIAGITKSFGFSCAYIFQLIFCMIFENKNWFRMLESKKATDIPAKDTVYRFLNQSTFNWRRFLLSLVASVIGKVSKLTRHDRPKVLILDDSSYDRNRSKHVELLARCFDHASQKMRFYKGFRMLTLGWSDGATFLPVDFSLLSSKKSQINGISENIDKRSSGYKRRKEALQTAPEQIPGMIARAMNSGIDASYVLMDSWFTQQPLIKEITEQGLDVIGMVKKLKQRYFVDGKRVSLDELYRLAKPTSGKKGILRSIHTTQANGVPIKVVFVRNRNKKSDWLAILSTDCTLSDQEIIRIYGMRWDIEVFFKTTKSLLKLQKEFQSRSYDALISHTTIVFARYIVLSWQNRCSVDDRTLGGMFYELCDEIDDLDWAVALQQLVEILEDTLDKSNKKIQQLIKSQLQQWIAGLPNYIKVYLPVSVCES
>NZ_CP010525.1|WP_014096684.1|116731_117178_+|threonine/serine-exporter-family-protein
MFQQLLTSFFASAGFGILFNAPRKLLIQCGITGMIGWGIYFLFYMYEQNVVYGTFIAAFFVGVISQVFARFYKTPILIFTVGGIIPLVPGGLAYDAMRHFVQNDYNGAVSLAAKVLLLSIAIAIGLVASEVANQFIKKLPDRRPKRMK
>NZ_CP010525.1|WP_014096683.1|115906_116656_+|threonine/serine-exporter-family-protein
MYQNEAQQVMRVCLLAGKIMLMSGAETYRVEDTMSRIAAAAGISGSHSFVTPTAIIFSLDGAELTKLIRISERSTDLRKVDQVNSISRQISNRGITLKEAYGQLKKIETEEEAYPLWLQFVAAAISSGCFVIIFLGGWIDFLPACIAGGLGFLSTHYIHRFVKVRFFAEFVASLVIGITAYILVHAGIGRELDKIIIGSVMPLVPGLAITNALRDLMAGHLFSGVTKGAEAFLTSFAIGSGIAIILTIF
>NZ_CP010525.1|WP_014096682.1|114379_115453_+|branched-chain-amino-acid-aminotransferase
MNQVIEFVKADVKKEKPAVESLGFGKHFTDYMFVMDYNEEEGWHQPRITPYAPLVLEPAAMVFHYSQSVFEGLKAYRAKDGRVLLFRPEKNVARMNVSCARLSIPQIDETIVLDAIKQLVELEKDWIPDGEGTSLYIRPFIIATEPSLGVHPAHEYKFMIILSPVGSYYGDQLKPVRIYVEDEYVRAVPGGVGFTKTGGNYAASLKAQEKAEELGYDQVLWLDGVERKYIEEVGSMNIFFKINGEVVTPKLNGSILGGVTRDSVIELLKYWNVPVKETKISIDEIYNAYKNGQLEEVFGTGTAAVISPVGELGWKDVAMQLPHAEAPDSIANRLYDALTGIQLGKTEDPLNWTVEIK
>NZ_CP010525.1|WP_035183153.1|112237_114040_+|carbon-starvation-protein-A
MNAITIVIGSICILMIAYRLYGTFMAVKVLKLNNDTPTPAHEFNDGKDYVPTNKWVTFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDAVVLFASMRRKGKSLSEVAKEEMGPVAGFCTGLSMLFIIVITMAGLSMVVVNALQNNPWGTFSVGITIPVAMGVGLFYKKTGNLKLTTTIGFLLIVAGVFAGPWIRHTVIGEWLTFDPKTLAIILPAYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIIGVFIINPPIHMPALSQFIHGGGPTMTGPVWPFISITIACGAISGFHAFIGSGTTPKMLDKWTDIKPVAFGAMLVESLVGVMALVAATALQPADYFAINSTPEVFKTLGMHVVNLPHLSSEIGMDLAGRTGGAVTLAVGMTYIFTKIHWFSNLAPYFYQFVILFEAVFILTAIDSGTRVARYLLQDFLGELYKPLKKTDWLPGSILTSAAACFMWGYLLYSGDIGSVWALFGVSNQLMASIGLIVGATVILKIADKKRYMFTCLIPLAYLYVTVNYAGYWMVKNVYLNHAAAGYNVLNGILSIIMLILGIVIMISALKNWYDLLRTPAMPDLEVSARKA
>NZ_CP010525.1|WP_035183151.1|111390_112107_+|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein
MLKAFVVDDEAPARDELIYLLKKTGQVELAGEAGSVKEALAKLKETEADIVFADMMLTNEHGIDLVKEISRYPQHPAVVFATAYDEYAVKAFELNAADYILKPFEEKRVAQTVAKVKKMLEGDRPAVPKNPGKLAVTTDERIVIIPVEKLLYAESVDGRTVIATDDKKYTITESLVNVEKKLPSTSIARVHRAYLVNLDGIVEIRPWFHSTYNLIMRDGAKIPVSRTYKHVLKQFIRI
>NZ_CP010525.1|WP_035183149.1|109634_111416_+|sensor-histidine-kinase
MATLLPVMLERAGILVIAAFLLSRLKTFRQIIHQEYGRKEKVVLIIVFGIFGIISNYTGIVIEHGKVSHAFGQGHLSVESAIANTRIMGVGIAGLLGGPVVGIGAGLLASIHRLSLGGYTDIACSLSTMIAGIIMGFIGRRFNVRGKYAALEAVAAGVLMEMLQMGIILAVAKPFEEAVALVRLIAVPMISINGFGTFIFILIIQTILLEEERTRAVQTHKALQIAQETLAHFRKGLNMQSCKEAAEIILKHTAADAVAITDREKVLAHAGVASDHHIPLESMSTKLTERVLLHGKIMVARTAKEIQCNHEGCPLQAAIVLPLFVREQVAGTLKLYFTSASQLSAVEQELAEGLSKLFSNQLELAEAELQRKLLKDAEIKALQAQVHPHFFFNAINTITCLVRTDADKARELLVQLAAFFRSNLQGAGKMLIPLEKELEHVKAYLAIEQARFPGWYHVHFDIDPLLHTAMVPPFTLQPLVENAVHHAFTQQFTKNPFIVVRARVKNGKFIMETEDNGKGISKEQVQSLGNVAVDSAEGTGTALWNIRKRIEEIYGHSAVFRIENRKTGGTKVAISIPLEEIWGGEYAEGICSG
>NZ_CP010525.1|WP_014096678.1|108556_109399_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKFAILLLGLILVLAGCGAKNNSSSTSTKTIKVGTTTSEVPTWNLIQKLAKKKNINIKIVRFDDYVQPNLALSDGEIDINAFQTVVYFDDFIKQRNLKLSAIGTTNIWPMGIYSKRYKKVSEVKDGDQVVIPKDPTNLGRALLLLQKAGLITTKKGFTGKGGLENVASNPKHLKITAVDAAQTPRGLDDSALAVINCDMAINAGLNPTNDSIFREDAGNKAYINIIAARTKDKNDKTLKEIVNIYHSKEVSDFIKKHYKGAAVPVNKPVSYLKDYKQTQ
>NZ_CP010525.1|WP_014096677.1|107832_108495_+|ABC-transporter-permease
MAFDWSWFWPQFFTAMGQTLYMVAVSLLISIIIGIPVGVILVITRENGIWENKWIFNILNVIINIFRSIPFIILVVAIIPFTRWVVGTAIGTTAAIVPLVLYTAFYIGRLIESSLLEVDKGTIELAQSMGATNWQIIWRFLLPEAKASMVLNLTIATIGLIGASAMAGAVGAGGIGDLAITYGYNQFQTGVMIVTVITLVIFTQLVQTLGNFLSKKIRRK
>NZ_CP010525.1|WP_014096676.1|106802_107843_+|methionine-ABC-transporter-ATP-binding-protein
MLVLEDIHKVYGKGKDKKVEALKGINLRVEKGEIFGVVGYSGAGKSTLIRCVNLLERPTSGKVLVNGVDLVRLPPAKLRQERKKIGMIFQQFNLLQSKTIFQNVAMPLVLEHRPKEEIKAKVAELLSFVGLEERMHHYPDQLSGGQKQRVGIARALATDPDILLCDEATSALDPNTTEAVLDLLRKVRDELGITILMITHEMNVIRDICDKVAVLDGGKIVEQGPVIDLFTEPKTQIARSFVKTVLNDSIPPSVQKLIDESSKDNPHGIYRILFKGASTNMPLLSNTAKQFSIDLNVLHGMITELQGIPFGNLLVELKGDPEEMKRAIQYINDHEAIIREVEKNGI
>NZ_CP010525.1|WP_035183159.1|120162_121176_-|DUF1646-family-protein
MISALIIILALVLLLPFFVPFVERNLEIFLFIMGWAAAIAGGVLDKPLLRKALEDPVNITIAVFVAGLLFRWLERPLEKVISAINRGIPFPLLAALTVILLGLLSSVITAIIAALILVVIVSVLRLDRKSETQLVVYSCFSIGLGAALTPIGEPLSTLAISKLGEDFFYLLRLIGPEVISAVVIFGILAAIVIKPEQSAIGLKTAHTRESYVEIAGRTVKIYLFVMGLTLLGAGFEPLINRFLLDLSPFILYWINMISAVLDNATLAAAEISPKMADKTVQAILLGLLISGGMLVPGNIPNIISAGKLRITSREWARFGLPIGLAAMAVYFVVILFV
>NZ_CP010525.1|WP_035183161.1|121529_123377_+|asparagine-synthase-(glutamine-hydrolyzing)
MCGITGWVDFQKDLRSELETVKKMTETLTKRGPDDTNYWLSPHAAFGHKRLVVVDPLCGVQPMTRQKDGKMYTICYNGELYNTEDLRAELLKKGYTYQGHSDTEVLLTAYIEWKEACVDRLNGIFAFVVWDGNKEQVFAARDRLGVKPFFYKAHGSGLLFGSEVKAMLAHPDVKAEVDEAGLAEIWGLGPSRTPGTGIFRGMAELRPAHALKMDRNGLKVWRYWNVKSAPHTEAAEETAETIRLLIQDAIVRQLVSDVPVCTFLSGGVDSSAITAIAAGHFQREGKGRLHTFSIDYEGNDRYFKANDFQPDADGVFIRKMSEAFDTVHHHCVITQEELAESLKAAVLARDVPGMADVDSSLLWFCREIKKDFTVSLSGECADEIFGGYPWFRREDDLNREGFPWMRSLDERIGLLKEGWQEKLQLKDYVMSKYEASVAETPLLDGETDLEKKRRQLFYINMLWFMTTLLDRKDRMSMGASLEVRVPFADHRIVEYVWNIPWEMKMYGGREKGILRKALEGILPEEILYRKKSPYPKTHHPAYTAAVKRWLGEVLEQKDSILYEFLHRDQLMELMETDGKAFRTPWFGQLMTGPQLLAYLAQIHYWFEIYRIDIKA
>NZ_CP010525.1|WP_014096689.1|123525_124467_-|LysR-family-transcriptional-regulator
MDIQHLQYFVSVATHGSFTKAARECYVSQPTISKMIKSFEEELGVPLFNRAGKKIVLTDAGQAVFQQAQKTLKAFRQLTDAINDVAGLKKGKIRIGLPPMIGSRYFPRVIDEFHHAYPDIKIQLVEDVTRKVVRDVENGTLDLGAVVMPVDDEVFGHFSFVHDRLVLLVHPSHRFAGCSSVRLKQLKEEEFIFFHRDFALHDQIIKECLKLGFMPNIIYESTQWDLICELVASNLGVALLPSTICHAFNPERVKIIHLEEPVLPWNLAIIWPKHQYLSFAVKEWIRFTKHLFGRGIPPAVPQPEEAMKKESEK
>NZ_CP010525.1|WP_035183163.1|124569_124947_+|CidA/LrgA-family-holin-like-protein
MKKVLIGMLQIVGLYLFAEVMGAAAKLLHIPLPGSMLAMIALFLLLQFGIVKMGWIEIGANFLMAELLLFFIPSAVGMVKYRNLLVHNGPEILVVILISLIAAMACSGWLADKIANRRSVRMRDR
>NZ_CP010525.1|WP_026684575.1|124936_125620_+|LrgB-family-protein
MIVKIVCLLLTVGSYWIFKKLYGKYKKIFVSPLLVTPVLLGAFLLGEDIPYRDYQKGTSVLTDLLQPAIVAFAVPLYRHFKIVRQYAVEILIGIGAGWLMAVFLSSAIATLFHFSKSLEHSIIPFTITTPIAMGVSEKIGGVPSVTAVFVILNAIIGSVMAPWLIKHLRIKNEIAHGILLGTHANGIGTSKAFELSARSGAISSVSMIIVAAISIFVTPWMVSHIIH
>NZ_CP010525.1|WP_164931356.1|125689_125836_+|hypothetical-protein
MGRQKYGNQNAERNKNAKLGNEIAEELVEFSTGRKDEIDQKKKKGVRK
>NZ_CP010525.1|WP_035183165.1|125943_126423_+|Cys-tRNA(Pro)-deacylase
MAKTTKTNAMRLLDAQQIPYGMLSYEVKDGKIDGISVAEKIGKPPEAVYKTLVTQGHSGELYVFVIPVAAELDLKKAAKAAGEKKIEMVHVKDIQKYTGYIRGGCSPIGMKKHYVTFVDESAATLDEVIVSAGRIGTQIVLAPGDLLKAADANYADLTH
>NZ_CP010525.1|WP_164931355.1|126499_126676_+|hypothetical-protein
MDKRDVEYQIADLKADYVRLQQDLEKLEYVKGNLHPLEKQLAEIEQALKKLYQQLDRF
>NZ_CP010525.1|WP_035183167.1|127547_128414_-|alpha/beta-hydrolase
MPYIQRRNAILAMICLFLMLSLSTVWFSYRTDKSNAAAAPPAQKPVPTVFVHGYKGTARSFNGMLGRLEKSGTAEKAMVIRVTKDGMIVVNGEISNRARHPMIQVIFSDNRASFRQTAGWLEKTMHILYTKYDVKEANLVGHSMGGLICTKYIEDTSGRRQYPDIQKLVTIGSPYEGVLTRVFKQNPNNTGDAARDLLPGSVALKALYANKSRFNPHIQVLAIAGVVNKPASGDSLVSLDSALFSRFIVPKKQYTSKIVYGKNAQHSSLHENKRVDRLVADFLWHAKK
>NZ_CP010525.1|WP_035183170.1|128669_129518_+|MurR/RpiR-family-transcriptional-regulator
MDSILERIQKEMHHFTGTEKKIGTYILEHPEMVPTMTTKDLSEKTGVSESSVVRFCKTIGIASFKTFKLELVKNLTLTESHMTDFSILQQKDSPYDLFQKVTYGNKKAIESCVSSLDRRELEKAANVLENARKVVFFGVGGSVTAAVDACYKFTRLGCQSIFSQDYHYLISLIPYMNKMDVFVALSVSGRTKDVLELADFAKRKGAKVIAITNMEKSPLYKQADIRLCTPISEEDFRIGTTSSRMAQLNIIDALYLSVFQRKGEDILKYYNETRNEYLRLRR

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Crispr_ID: NZ_CP010525_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_3

669382-669482

Orphan

Consensus_repeat	Method
CCGAGTGAACCGGTTTTATCAACAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_3

>merge|NZ_CP010525|3|669382-669482|CRISPRCasFinder
CCGAGTGAACCGGTTTTATCAACACCGCTCGTTGGTGCCCGCTTATCGCGCAGTTGGATTTCTGCCTTCTCCCCGCCCAAGTGAACCGGTTTTATCAACAC

>NZ_CP010525|3|3|669382-669482|CRISPRCasFinder
CCGAGTGAACCGGTTTTATCAACAC	CGCTCGTTGGTGCCCGCTTATCGCGCAGTTGGATTTCTGCCTTCTCCCCGC
CCAAGTGAACCGGTTTTATCAACAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_128890973.1\|661101_661296_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035183672.1\|657840_658620_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|181069
NZ_CP010525.1\|WP_035183631.1\|663552_665724_+\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NZ_CP010525.1\|WP_035183627.1\|661466_662030_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223566
NZ_CP010525.1\|WP_035183644.1\|675007_675598_+\|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl\|CDD\|274099
NZ_CP010525.1\|WP_014097177.1\|678861_679299_+\|YwnF-family-protein	unknown	unknown	gnl\|CDD\|375160
NZ_CP010525.1\|WP_035183640.1\|672303_673341_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226167
NZ_CP010525.1\|WP_035183621.1\|656801_657710_+\|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|180206
NZ_CP010525.1\|WP_035183646.1\|676460_677819_-\|4-aminobutyrate--2-oxoglutarate-transaminase	unknown	unknown	gnl\|CDD\|235885
NZ_CP010525.1\|WP_035183624.1\|658624_660142_+\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|227136
NZ_CP010525.1\|WP_017553523.1\|675590_675968_+\|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	unknown	unknown	gnl\|CDD\|184702
NZ_CP010525.1\|WP_013860453.1\|662852_663038_+\|type-Z-30S-ribosomal-protein-S14	unknown	unknown	gnl\|CDD\|181216
NZ_CP010525.1\|WP_035183642.1\|674002_674995_+\|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl\|CDD\|237724
NZ_CP010525.1\|WP_035183633.1\|665973_667269_-\|purine/pyrimidine-permease	unknown	unknown	gnl\|CDD\|225142
NZ_CP010525.1\|WP_014097147.1\|660289_660736_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379240
NZ_CP010525.1\|WP_035183638.1\|671154_671898_-\|oxygen-insensitive-NADPH-nitroreductase	unknown	unknown	gnl\|CDD\|380322
NZ_CP010525.1\|WP_035183636.1\|669495_670830_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP010525.1\|WP_080738166.1\|667929_668886_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_CP010525.1\|WP_014097176.1\|678106_678865_+\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232
NZ_CP010525.1\|WP_014097178.1\|679590_679836_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_035183672.1\|657840_658620_+\|enoyl-CoA-hydratase	gnl\|CDD\|181069	PRK07657, PRK07657, enoyl-CoA hydratase; Provisional.	2.02617e-128
NZ_CP010525.1\|WP_035183638.1\|671154_671898_-\|oxygen-insensitive-NADPH-nitroreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	2.89486e-100
NZ_CP010525.1\|WP_035183631.1\|663552_665724_+\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	1.85552e-113
NZ_CP010525.1\|WP_035183627.1\|661466_662030_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	5.88421e-27
NZ_CP010525.1\|WP_035183644.1\|675007_675598_+\|dihydroxyacetone-kinase-subunit-L	gnl\|CDD\|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	2.22571e-80
NZ_CP010525.1\|WP_014097177.1\|678861_679299_+\|YwnF-family-protein	gnl\|CDD\|375160	pfam17370, DUF5392, Family of unknown function (DUF5392). This is a family of unknown function found in Bacilli. Family members are predicted to have 2 trans-membrane regions.	3.18838e-62
NZ_CP010525.1\|WP_035183640.1\|672303_673341_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|226167	COG3641, PfoR, Predicted membrane protein, putative toxin regulator [General function prediction only].	4.40699e-79
NZ_CP010525.1\|WP_035183621.1\|656801_657710_+\|hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|180206	PRK05692, PRK05692, hydroxymethylglutaryl-CoA lyase; Provisional.	7.82748e-174
NZ_CP010525.1\|WP_035183646.1\|676460_677819_-\|4-aminobutyrate--2-oxoglutarate-transaminase	gnl\|CDD\|235885	PRK06918, PRK06918, 4-aminobutyrate aminotransferase; Reviewed.	0
NZ_CP010525.1\|WP_035183624.1\|658624_660142_+\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NZ_CP010525.1\|WP_017553523.1\|675590_675968_+\|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	gnl\|CDD\|184702	PRK14484, PRK14484, phosphotransferase mannnose-specific family component IIA; Provisional.	5.85206e-48
NZ_CP010525.1\|WP_013860453.1\|662852_663038_+\|type-Z-30S-ribosomal-protein-S14	gnl\|CDD\|181216	PRK08061, rpsN, type Z 30S ribosomal protein S14.	3.68276e-36
NZ_CP010525.1\|WP_035183642.1\|674002_674995_+\|dihydroxyacetone-kinase-subunit-DhaK	gnl\|CDD\|237724	PRK14481, PRK14481, dihydroxyacetone kinase subunit DhaK; Provisional.	0
NZ_CP010525.1\|WP_035183633.1\|665973_667269_-\|purine/pyrimidine-permease	gnl\|CDD\|225142	COG2233, UraA, Xanthine/uracil permeases [Nucleotide transport and metabolism].	7.1257e-62
NZ_CP010525.1\|WP_014097147.1\|660289_660736_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379240	pfam13527, Acetyltransf_9, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	5.90984e-18
NZ_CP010525.1\|WP_035183636.1\|669495_670830_-\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	1.45095e-149
NZ_CP010525.1\|WP_080738166.1\|667929_668886_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	6.93385e-29
NZ_CP010525.1\|WP_014097176.1\|678106_678865_+\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	1.55428e-89

>NZ_CP010525.1|WP_080738166.1|667929_668886_-|sulfite-exporter-TauE/SafE-family-protein
MRIIPLHQDESNLWMKKAGNMNMQKLIVLALVGLAAQLVDGSLGMGYGVTSTSLLLAFGIAPAVASASVHLAEVFTTAASGVSHMKFGNVDKGIIWKLVVPGAVGAFLGATVLSHLPASTLKPYISIFLIALGLYILIRFLINARGALKVKKKTGSNVFFIPLGFVAGFFDATGGGGWGPIATPALLSRNDIEPRKVIGSVDTSEFAVSLASSIGFLLSLGAMQINWIWTIALMLGGLIAAPIAAYLVKILPAHLLAVIVSGMIVFSNVQTLLKMAGAGSGWYGVTYTAIAAIWAILIFYTIRRHKRAVASASVSVTE
>NZ_CP010525.1|WP_035183633.1|665973_667269_-|purine/pyrimidine-permease
MKTLISSLQWMAFMIAGSIAAPIAIADAFHFSAGETALFVQRTLFVLGIGGLLQGIFGHRMPINEGPAGLWWSVFAIYAGLVGSLYSSSTESLQYLAGALIVTGIFFFLLAFTGFVDQLNKLFTPVVTFIYLLLLVLQLSGSFMKGMLGITGAHQEVRPLVAVLSLVTVLLTFYFGHVKKPWVKQYSIMLGLICGWILFALFGEAPAITFGESWFSLPAVFDFGKPRFDSGAVTTGVFIGLLLTANMITSVRVMGNVTGVRQERVRSSLFISGINQLLAGIFSAVGAVPIAAAAGYVAQTGIKVLKPFLYGACFVSIIALLPPLVHIMSAIPAPVGYAVTFVVFTQLVGLALNDLEKSPDKEIAHTTAGISFLVGIGAMFLPAHATEHLPMMIATFLNNGLILGSVVGILTEQLLIWRKKRNTQENSIREQ
>NZ_CP010525.1|WP_035183631.1|663552_665724_+|ATP-dependent-helicase
MNTNQDFFTRKKEESGIVVNAVQQEAVKQTEGPLLLLASPGSGKTTTVIMRIGYLIEEKGVAPARIKAITFSRAAAADMKDRFQKLFPNLPPVDFSTIHSLAFELVRVFFRRTNVPFLLIEGEAGPYHKKKILRDVYKAINGERITEDQLEELQTYISYIKNKMIPPAKWGKIATGVPEAARILKEYEAFKKQGTGQLLLDFDDMLTHANEIFRRDPNLLCMYQGRYDYVLTDESQDTSMVQHAIVEKLVRRHRNLCVVADDDQSIYSWRGAEPSYLLNFKKVYPDAKILFMEQNYRSSQEVVTAANLFIKRNKHRYDKNMFTENPPAGPIRFVRLPDYKYQAKYLAQNIAASENFSEIAVLYRNNMSSIALINEFDREGIPFYIKDTDNRFFSHWVVQDILNVMRLTFTDKRADILAQVHSKLDGYITKQQMEAVKGIHNNQSVFDNLIQYAHLKDYQVQKVREVKETLREMRGMPPLDAIHVIRGRLGYEKALENMCKRLGFRKDPLIGILNTLEEIADTLSTMEEFAARLQHLAHILKTAKGNKGRHAVTLSTFHSSKGLEFEKVYMIDLVDGIIPGNDEKEDDLLMEESVRLFYVAMTRAKKSLEMVSYEKRNGSRAMDSPFVAAVKGIVNSVEKAGKTKPEIEVARIGKKTVSIPQNPNAIKDASAFVAGKKIQHRVFGHGEIVDIDGDTLAIRFEKRTIKLSALTCIEKGLLEEADL
>NZ_CP010525.1|WP_013860453.1|662852_663038_+|type-Z-30S-ribosomal-protein-S14
MAKKSMIVKQKREPKFKVQAYTRCERCGRPHSVYRKFKLCRICFRELAYKGEIPGVKKSSW
>NZ_CP010525.1|WP_035183627.1|661466_662030_+|FAD-dependent-oxidoreductase
MYEIAIIGAGPAGASAAIFTAKAGKSTVLFDGGTSATKRALLKNHYGVTEITGPDLVETGKKQAAQFGAELVDEKVESIEKTENGFTIKTEQGSYESKYVILATGMIASLGEALGVKAKPATEPRVKTVFAVDAQGKTNVPNVWACGTVAGVSMHTIITAGDGAKVAVNLISEIDGKRWVDHDVLGK
>NZ_CP010525.1|WP_128890973.1|661101_661296_+|hypothetical-protein
MRAIIEANLIGDYNLSYETLGKYANVPCDVLKAFCEGNDHIDIDHLMNICVNLLMLSFVLRPEL
>NZ_CP010525.1|WP_014097147.1|660289_660736_+|GNAT-family-N-acetyltransferase
MEFRKANLDDLHHLIELRKQQQVAQGIEPKTDIDADLEKFFQKKLKEGSMVQWLAEDEGEIVACGAVIFYEFPPSYVNKSGKKAYITNVYTKEEYRGQGIAKELMEKLMDEVKKAGISNIWLGASEMGKPLYEKFGFQEVDEWMELHL
>NZ_CP010525.1|WP_035183624.1|658624_660142_+|acyl-CoA-carboxylase-subunit-beta
MDYESKKAEILKGGKEKYHQKNREQGKWFVRERLRMLLDDGLKAEDGMFANVLAGDLPADGVVTGLGKIGGRTVCVMANDSTVKAGSWGWRTVEKIIRIQETAAKLNCPILYLVDSAGARITDQIEMFPGRRGAGRIFYNEVHLSGKVPQICLLFGPSAAGGAYIPAFCDIVVMVEGNASMYLGSPRMAEMVIGEKVTLEQMGGAKMHCTVSGCGDVLVKTEEEAIRYVQKYLTYFPDNFSEKPARTEAKAPAAFEKTIEELIPKNENAPFDMYQLIERIVDEDSICEIKKKFAPELITCLARIGGRPVGIIANQPRVKGGVLFHDSADKAAKFIHLCDAFHIPLLFLADVPGFMIGTQVERAGIIRHGAKMIFAMSEATVPKLSVIVRKAYGAGLYAMAGPAFEPDCCIALPSASIAVMGPEAAVNAVYANKIAALPEEERPAFFAEKRAEYVKDIDIYRLASELVVDDVVPGNELREELERRLEMYSGKQEEFSKPKHPVYPV
>NZ_CP010525.1|WP_035183672.1|657840_658620_+|enoyl-CoA-hydratase
MTGTVLLEKQDGITVMTLNRPEAANALSKEMLSDMHEALSEVKKDQSTRVVILTGAGEKVFCAGADLKERKGMNEEEVLQAVRKIGAVVNETAALPQPVIAALNGSAFGGGLELALACDLRIGAREAKYGLTETSLAIIPGAGGTQRLPRLIGVGKAKELIYTARRLTAEEAAAIGLLEYAVPRAAVIEKAFELAGEMQKNGPIALRQAKTAIDQGTETGLSAGLKIEELAYNALIPTEDRLEGLRAFAEKRTPVYKGR
>NZ_CP010525.1|WP_035183621.1|656801_657710_+|hydroxymethylglutaryl-CoA-lyase
MKLPEKVTVKEVGPRDGLQNEKAVVATAEKVAWVNALSDTGLTYIEAGSFVRPEWIPQLADTGAVLEKIRRKPGVTYAALVPNVRGLERALNAGVDEVSVFMSASEGHNLRNINKTIAETYPVLEKVVKEAKNAGKSVRGYISTVIACPYDGPVSPKQVKEVAGRLFAMGVDEISLGDTIGAGVPTDVERLLGELLKDFHARQLAMHFHDTRGTALANVVKSLEMGITVFDSAAGGLGGCPYAKGAAGNVATEDLLYLFAQMGIETGVDLGRIIQAAQQIEKTIGRPLASHQMEIYRMAGGA
>NZ_CP010525.1|WP_035183636.1|669495_670830_-|amino-acid-permease
MEKNKHHLQKGLSPRHVQFIALAGMIGTGIFKGSSDTVSLAGPSVAVSYLIGGALLFIVMSALGEMALVHPGLNVQNLIHKAFGSRVSFIIGWLYWINWVIVTVVELLAAGSFLQFWVPQAPLWLLSLLCAAFVVGINLIEVKYYGEFEFWIAGIKIITLIVFILLGALILFGLFPGTSSTVSNYTAHGGFFPNGLHGTFSAFLIVMFSYGGAELIGVTVSETKDSEKVLPRVIKQTVVRVMLFYILPILIICGIIPWNQVSSVESPFVQVFSRTGIPAAAHVMNFVLLTAVLSAANSGIYATSRTLFNMAQSGEAPRAFLKISRKGVPLTSILLTSLFILAGVILAYLTPDEVISYLMTIPGFTVVLVWIAICAAELRLRKSYAKLPSFRVKGYPFMVWIALLALSGIFLSFLLGGGNPIGTSVCLAILIVLVVLSLRIKGKE
>NZ_CP010525.1|WP_035183638.1|671154_671898_-|oxygen-insensitive-NADPH-nitroreductase
MNTIIETILNHRSIRHYEDRPLSDEQIRLIVESAQAAATSHFVQAYTILGIQDPGRKQKLAELTGNRHVGTCGHLLIFCADLHKHELAAQMEGVEAQDTLETTEKFMVALIDTALAAQNAALAAESMGLGICYVGGLRNRLPEVAELLKIPQYVLPLFAMTIGYPADPSAKKPRMEAEHVYFEDEYPADERLLRDLKEYNETVSQYYTKRTNGKRNDTWTGQMAQFFKEPSRVFMKEFVERQGFDKK
>NZ_CP010525.1|WP_035183640.1|672303_673341_-|PTS-sugar-transporter-subunit-IIC
MKDFFSKLLNGMSIGIVVSLIPNALLGEILKLIIPHAPYLQHVVDATVIIMSMLPVLIGVMVGITFQLTPIQIASVGIAAMVGSGAIQKTAAGAFALNGIGIVINTGITAALAVLFVKWVGTRLKAYSILLVPTLSILIPGMIGLTILPFIKAATGLVGVGVAHVTSMQPVVMGAIIAVIFCLIILSPISTVGVATVIMLSGVSSGAANLGICAAGVGLAIASYKANSLGTALAHVLGSPKIQMRNFFMKPKIAFPMLITAAVLGALAGVFHIQGTPYSAGFGLSGLVGPLNFMHLAEGGWTAKNIAIMLSTFFVLPFILNVGFIYVFSKKLKMIKSEDYQLNFE
>NZ_CP010525.1|WP_035183642.1|674002_674995_+|dihydroxyacetone-kinase-subunit-DhaK
MKKIINDPGKVVDEMLDGFVYAHEGKVERLEGTGVIYRTFRDEGKVALISGGGSGHEPSHAGFVGEGMLSAAVCGEVFTSPTPNQIFEAIKKADQGAGVFMIVKNYTGDVMNFDMAQELAEMEDIQVEKIVVDDDIAVEDSTYTAGKRGVAGTVLVHKILGAAAAEGQTLQEIKALAERLVPNVKTIGVAISPATVPEVGKPGFVLQEDEMEYGVGIHGEPGYRREKIKSSKAIAEELVTRLKNAFNWKEGDRFALLVNGLGATPLMEQYIFTKDVHALLDREGLTVPFRKVGNLMTSIDLAGLSLTLVKLEDEAWLKFLKRPVSVPAWV
>NZ_CP010525.1|WP_035183644.1|675007_675598_+|dihydroxyacetone-kinase-subunit-L
MLTAETATDWLHRFAEKINENKAYLSELDSAIGDGDHGSNMARGVAAMEEKLAAGGFATVQDVLKTAAMALLGKVGGASGPLYGSALIAMAKQAGENEQDVAAIVKAGLEGIQKRGKAEKGEKTMVDVWMPACEALASGSLTKEVIQSAVEATKEMKATKGRASYLGERSIGHLDPGAVSSSYLFEALLEGGILDE
>NZ_CP010525.1|WP_017553523.1|675590_675968_+|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM
MSKKPVGIVIVSHIPEIAAGLATLLKEAAKDVSITYAGGTDDGGVGTSFDKINAAIAENKADDLFAFYDLGSAKMNLEMAMEMSDKYIRLMDTAFVESAYTAAALIQADAELEEILKQLEPLKVK
>NZ_CP010525.1|WP_035183646.1|676460_677819_-|4-aminobutyrate--2-oxoglutarate-transaminase
MTNANVYSSLPGPLSKELLERREKAVPRGVSNGIPAFAKEAKGALVTDVDGNTYIDFAGAIGTLNVGHNHPKVVAAVKEQLERFIHTGFNVMMYEPYIELAEKLAALAPGNAEKKVILLNSGAEAVENAVKIARKYTKRPAIISFTRGFHGRTLMTMSMTSKVKPYKYEFGPFASEVYKAPYPYAYRKPGNLTDEEYEDYMIQEFRNFFQNDVAAETVAAVVMEPVQGEDGFIVPGKKFVKAVYDFCQENGILFVSDEIQAGFSRTGRYFAIEHFDVVPDLITISKSLAAGVPLSGVIGRSDIMDAANPGELGGTYAGSPLGCAAALAVLDIIESEKLNERAEKIGRHVLDTFRSWQKEFTFIGDVRGLGAMCAFEVVKDKTTKEPDKALTKRIVKEANKRGLLLLDAGIFGNVIRILMPIVITDDQLQEGLDILKQSIAAAASVEEEVTLL
>NZ_CP010525.1|WP_014097176.1|678106_678865_+|GTP-pyrophosphokinase-family-protein
MEVAIPIDFEQMKEVKTELTRFMMSYKFALHEVMTKIDILKEEFQYVHDYNPIEHVKSRLKSPESILNKAYRKGCALSLDSIRENIRDIAGIRITCSFISDIYEISKMIQQQKDVKLIECKDYIQNPKPNGYQSLHMIIKIPVFMSDRSEEVYVEIQIRTIAMDFWASLEHKIYYKYDEDVPQHLKEELKEAALQAAQLDVKMENIQKEMKEVKKRNSENSVHQLIVDTEKLRIPEDFLKAALNETDGKGSI
>NZ_CP010525.1|WP_014097177.1|678861_679299_+|YwnF-family-protein
MIINLNEMPGFVRFEMEKLGEMIAPKLKKANQYAFWSKPLIFVAALNLFLLLLVMPAEDRSIPLLLFCAVAGAFGMALSQEARVLRKEITKLSFSYMKKRIEKSSIVPDSVKKRYAALIEKEPTNIFLHFIHFLEEEQNRKKELW
>NZ_CP010525.1|WP_014097178.1|679590_679836_-|hypothetical-protein
MGTKTLFLPYRWTVVIHESYHLYTNQEDQYAFAVLDGELDTVVAFSVRDASVQVSNCGYDVNLDINVETRLITIGHEPERE

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Crispr_ID: NZ_CP010525_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_4

709156-711900

TypeI

I-C

Consensus_repeat	Method
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	PILER-CR
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CRISPRCasFinder
GTCGCTCCCTACATGGGGGCGTGGATTGAAATN	CRT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CRISPRCasFinder

41 spacers

cas2,cas1,cas4,cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_CP010525_4

>merge|NZ_CP010525|4|709156-711900|PILER-CR,CRISPRCasFinder,CRT,CRISPRCasFinder
GTCGCTCCCTACATGGGGGCGTGGATTGAAATCGCCGACAAATACAAATGAATTTCACTCGTCAACGTCGCTCCCTACATGGGGGCGTGGATTGAAATATCAAGCGGAAAGCACGTTGGCAAATGGGCGGTGTCGCTCCCTACATGGGGGCGTGGATTGAAATTGGAACAGTTAACGTCAGACAATTTACAGGGCTGTCGCTCCCTACATGGGGGCGTGGATTGAAATCCAAACGATCAGGGATAAAGTATGGGATGAGTGGGTCGCTCCCTACATGGGGGCGTGGATTGAAATATCTAATTCAACTAATGAACCGTCATCGTATCTGCTGTCGCTCCCTACATGGGGGCGTGGATTGAAATTTCCCGCTGCTGGTTGATCAGCTTTTTCTGTTCTGTCGCTCCCTACATGGGGGCGTGGATTGAAATAGACGACAAATACGACTTACTTTGGTACAAGTTATGTCGCTCCCTACATGGGGGCGTGGATTGAAATTACATCTGGCACATACACGTTAAAGCTGGACGAGCGTCGCTCCCTACATGGGGGCGTGGATTGAAATCGGGTCAAAATCCAAAAGGTTTAAAGCATCGCTAGTCGCTCCCTACATGGGGGCGTGGATTGAAATTTCTAGCGTTATAACCGGGCGGTCTGGCATTTTGCCGTCGCTCCCTACATGGGGGCGTGGATTGAAATCGCGCTATGCTACTGGAATAGGGACATTGCCACGTCGCTCCCTACATGGGGGCGTGGATTGAAATCTAAACCGTGACAAGCAAAATCCGAAACACGACAAGTCGCTCCCTACATGGGGGCGTGGATTGAAATCCAAGCTCGATATAATAATCAGCAAAAGCCTGCTGTCGCTCCCTACATGGGGGCGTGGATTGAAATGTAGACAATGCGTTGTAATTCCGAGTCAAAAAGTGTCGCTCCCTACATGGGGGCGTGGATTGAAATGAACTTAACGACGGAATCGAACTCGACAGCGACGGTCGCTCCCTACATGGGGGCGTGGATTGAAATGCACCATGCTCATCGGGCAAAGGAAAACATCCTGTCGCTCCCTACATGGGGGCGTGGATTGAAATGTTGCAGAACAAGGCTTTGATGGCATCGATTATAGTCGCTCCCTACATGGGGGCGTGGATTGAAATCCGTCATCAATTTTGCACCGGATTGTGCATCCTGGTCGCTCCCTACATGGGGGCGTGGATTGAAATAGGCAGATCACCCGGATCTTTTGGACCGGGAAATGTCGCTCCCTACATGGGGGCGTGGATTGAAATAGTTAAAAATTGTCGGTTTTTGCCGTCCGTATCGTCGCTCCCTACATGGGGGCGTGGATTGAAATTATGCGCAGCTGGCCTGTCTCTACCGCCTGCATTGTCGCTCCCTACATGGGGGCGTGGATTGAAATATCAAGCCACTCAGGCGGGGTATGGGATGAGTGGGTCGCTCCCTACAGGGGGCGTGGATTGAAATGCCACTACCACCACATTCCGGGTCAATGAATGGGTCGTCGCTCCCTACATGGGGGCGTGGATTGAAATTTGGATATCGTATTTTGCGATGTATGCGGCCACCGGTCGCTCCCTACATGGGGGCGTGGATTGAAATGCCTTTGCTTGCAGGTCCTGGACAATTTCCGGCGTCGCTCCCTACATGGGGGCGTGGATTGAAATTGATCAATGGTGCTCACTCTATAAAATCACTCGGTCGCTCCCTACATGGGGGCGTGGATTGAAATACGTTGCAGCCAGTCGCCGATTGCGGTCCCCTGCGGTCGCTCCCTACATGGGGGCGTGGATTGAAATATCAAGCCACTCAGGCGGGTTCACATGCGCGGCACGTCGCTCCCTACATGGGGGCGTGGATTGAAATTTTCTTTGCCATTTTTTCATTCCTCCTTGTTGTTGTCGCTCCCTACATGGGGGCGTGGATTGAAATGCCACTACCACCACATTCCGGGTCAATGAATGGGTCGTCGCTCCCTACATGGGGGCGTGGATTGAAATTGATCAATGGTGCTCACTCTATAAAATCACTCGGTCGCTCCCTACATGGGGGCGTGGATTGAAATGCCAGTACATCGGTCACGTCGGTTATGACGTCTATCGTCGCTCCCTACATGGGGGCGTGGATTGAAATAAGACGCCTACCAGTTAATTGCGGTCGATACGGAGTCGCTCCCTACATGGGGGCGTGGATTGAAATCTGTTTGAATGCACGGGACTGACTGAATACTGGGTCGCTCCCTACATGGGGGCGTGGATTGAAATCGGTGCATCCTTGAGTGCTTCAATATGGTGCACGTCGCTCCCTACATGGGGGCGTGGATTGAAATTGCCGGAGGACCTGGATACAGCTATCCAGCATTAGTCGCTCCCTACATGGGGGCGTGGATTGAAATTGCAATGGCAGGGAGCCTTAATCTTTCCCACTTTGTCGCTCCCTACATGGGGGCGTGGATTGAAATCATTCCTCCATGCTCCACCCCGTCCACGCTTGTAGTCGCTCCCTACATGGGGGCGTGGATTGAAATCTTTAAATACGCGGAAACATCCCCATAGTTTGCAGGTCGCTCCCTACATGGGGGCGTGGATTGAAATCTCCTCCAATATGTATAGATCGTCAACCTTCACCCGTCGCTCCCTACATGGGGGCGTGGATTGAAATCGTTTGCTGTATTTGCGATCCCTAGGATCATCAAGTCGCTCCCTAATGAATACTTGCTGAGCAAAC

>NZ_CP010525|4|1|709156-711834|PILER-CR
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGCCGACAAATACAAATGAATTTCACTCGTCAAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCAAGCGGAAAGCACGTTGGCAAATGGGCGGT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGGAACAGTTAACGTCAGACAATTTACAGGGCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CCAAACGATCAGGGATAAAGTATGGGATGAGTGG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCTAATTCAACTAATGAACCGTCATCGTATCTGCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTCCCGCTGCTGGTTGATCAGCTTTTTCTGTTCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AGACGACAAATACGACTTACTTTGGTACAAGTTAT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TACATCTGGCACATACACGTTAAAGCTGGACGAGC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGGGTCAAAATCCAAAAGGTTTAAAGCATCGCTA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTCTAGCGTTATAACCGGGCGGTCTGGCATTTTGCC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGCGCTATGCTACTGGAATAGGGACATTGCCAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTAAACCGTGACAAGCAAAATCCGAAACACGACAA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CCAAGCTCGATATAATAATCAGCAAAAGCCTGCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GTAGACAATGCGTTGTAATTCCGAGTCAAAAAGT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GAACTTAACGACGGAATCGAACTCGACAGCGACG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCACCATGCTCATCGGGCAAAGGAAAACATCCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GTTGCAGAACAAGGCTTTGATGGCATCGATTATA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CCGTCATCAATTTTGCACCGGATTGTGCATCCTG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AGGCAGATCACCCGGATCTTTTGGACCGGGAAAT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AGTTAAAAATTGTCGGTTTTTGCCGTCCGTATC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TATGCGCAGCTGGCCTGTCTCTACCGCCTGCATT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCAAGCCACTCAGGCGGGGTATGGGATGAGTGG
GTCGCTCCCTACAGGGGGCGTGGATTGAAATG	CCACTACCACCACATTCCGGGTCAATGAATGGGTCG
TCGCTCCCTACATGGGGGCGTGGATTGAAATT	TGGATATCGTATTTTGCGATGTATGCGGCCACCGG
TCGCTCCCTACATGGGGGCGTGGATTGAAATG	CCTTTGCTTGCAGGTCCTGGACAATTTCCGGCG
TCGCTCCCTACATGGGGGCGTGGATTGAAATT	GATCAATGGTGCTCACTCTATAAAATCACTCGG
TCGCTCCCTACATGGGGGCGTGGATTGAAATA	CGTTGCAGCCAGTCGCCGATTGCGGTCCCCTGCGG
TCGCTCCCTACATGGGGGCGTGGATTGAAATA	TCAAGCCACTCAGGCGGGTTCACATGCGCGGCACG
TCGCTCCCTACATGGGGGCGTGGATTGAAATT	TTCTTTGCCATTTTTTCATTCCTCCTTGTTGTTG
TCGCTCCCTACATGGGGGCGTGGATTGAAATG	CCACTACCACCACATTCCGGGTCAATGAATGGGTCG
TCGCTCCCTACATGGGGGCGTGGATTGAAATT	GATCAATGGTGCTCACTCTATAAAATCACTCGG
TCGCTCCCTACATGGGGGCGTGGATTGAAATG	CCAGTACATCGGTCACGTCGGTTATGACGTCTATCG
TCGCTCCCTACATGGGGGCGTGGATTGAAATA	AGACGCCTACCAGTTAATTGCGGTCGATACGGAG
TCGCTCCCTACATGGGGGCGTGGATTGAAATC	TGTTTGAATGCACGGGACTGACTGAATACTGGG
TCGCTCCCTACATGGGGGCGTGGATTGAAATC	GGTGCATCCTTGAGTGCTTCAATATGGTGCACG
TCGCTCCCTACATGGGGGCGTGGATTGAAATT	GCCGGAGGACCTGGATACAGCTATCCAGCATTAG
TCGCTCCCTACATGGGGGCGTGGATTGAAATT	GCAATGGCAGGGAGCCTTAATCTTTCCCACTTTG
TCGCTCCCTACATGGGGGCGTGGATTGAAATC	ATTCCTCCATGCTCCACCCCGTCCACGCTTGTAG
TCGCTCCCTACATGGGGGCGTGGATTGAAATC	TTTAAATACGCGGAAACATCCCCATAGTTTGCAGG
TCGCTCCCTACATGGGGGCGTGGATTGAAATC	TCCTCCAATATGTATAGATCGTCAACCTTCACCCG
TCGCTCCCTACATGGGGGCGTGGATTGAAAT

>NZ_CP010525|4|4|709156-710576|CRISPRCasFinder
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGCCGACAAATACAAATGAATTTCACTCGTCAAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCAAGCGGAAAGCACGTTGGCAAATGGGCGGT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGGAACAGTTAACGTCAGACAATTTACAGGGCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CCAAACGATCAGGGATAAAGTATGGGATGAGTGG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCTAATTCAACTAATGAACCGTCATCGTATCTGCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTCCCGCTGCTGGTTGATCAGCTTTTTCTGTTCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AGACGACAAATACGACTTACTTTGGTACAAGTTAT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TACATCTGGCACATACACGTTAAAGCTGGACGAGC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGGGTCAAAATCCAAAAGGTTTAAAGCATCGCTA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTCTAGCGTTATAACCGGGCGGTCTGGCATTTTGCC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGCGCTATGCTACTGGAATAGGGACATTGCCAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTAAACCGTGACAAGCAAAATCCGAAACACGACAA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CCAAGCTCGATATAATAATCAGCAAAAGCCTGCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GTAGACAATGCGTTGTAATTCCGAGTCAAAAAGT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GAACTTAACGACGGAATCGAACTCGACAGCGACG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCACCATGCTCATCGGGCAAAGGAAAACATCCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GTTGCAGAACAAGGCTTTGATGGCATCGATTATA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CCGTCATCAATTTTGCACCGGATTGTGCATCCTG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AGGCAGATCACCCGGATCTTTTGGACCGGGAAAT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AGTTAAAAATTGTCGGTTTTTGCCGTCCGTATC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TATGCGCAGCTGGCCTGTCTCTACCGCCTGCATT
GTCGCTCCCTACATGGGGGCGTGGATTGAAATATCAAGCCACTCAGGCGGGGTATGGGATGAGTGGGTCGCTCCCTACAGGGGGCGTGGATTGAAATGCCACTACCACCACATTCCGGGTCAATGAATGGGTCGTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTGGATATCGTATTTTGCGATGTATGCGGCCACCG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCCTTTGCTTGCAGGTCCTGGACAATTTCCGGC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGATCAATGGTGCTCACTCTATAAAATCACTCG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ACGTTGCAGCCAGTCGCCGATTGCGGTCCCCTGCG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCAAGCCACTCAGGCGGGTTCACATGCGCGGCAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTTCTTTGCCATTTTTTCATTCCTCCTTGTTGTT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCCACTACCACCACATTCCGGGTCAATGAATGGGTC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGATCAATGGTGCTCACTCTATAAAATCACTCG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCCAGTACATCGGTCACGTCGGTTATGACGTCTATC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AAGACGCCTACCAGTTAATTGCGGTCGATACGGA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTGTTTGAATGCACGGGACTGACTGAATACTGG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGGTGCATCCTTGAGTGCTTCAATATGGTGCAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGCCGGAGGACCTGGATACAGCTATCCAGCATTA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGCAATGGCAGGGAGCCTTAATCTTTCCCACTTT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CATTCCTCCATGCTCCACCCCGTCCACGCTTGTA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTTTAAATACGCGGAAACATCCCCATAGTTTGCAG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTCCTCCAATATGTATAGATCGTCAACCTTCACCC


>NZ_CP010525|4|1|709156-711900|CRT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGCCGACAAATACAAATGAATTTCACTCGTCAAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCAAGCGGAAAGCACGTTGGCAAATGGGCGGT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGGAACAGTTAACGTCAGACAATTTACAGGGCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CCAAACGATCAGGGATAAAGTATGGGATGAGTGG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCTAATTCAACTAATGAACCGTCATCGTATCTGCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTCCCGCTGCTGGTTGATCAGCTTTTTCTGTTCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AGACGACAAATACGACTTACTTTGGTACAAGTTAT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TACATCTGGCACATACACGTTAAAGCTGGACGAGC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGGGTCAAAATCCAAAAGGTTTAAAGCATCGCTA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTCTAGCGTTATAACCGGGCGGTCTGGCATTTTGCC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGCGCTATGCTACTGGAATAGGGACATTGCCAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTAAACCGTGACAAGCAAAATCCGAAACACGACAA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CCAAGCTCGATATAATAATCAGCAAAAGCCTGCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GTAGACAATGCGTTGTAATTCCGAGTCAAAAAGT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GAACTTAACGACGGAATCGAACTCGACAGCGACG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCACCATGCTCATCGGGCAAAGGAAAACATCCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GTTGCAGAACAAGGCTTTGATGGCATCGATTATA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CCGTCATCAATTTTGCACCGGATTGTGCATCCTG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AGGCAGATCACCCGGATCTTTTGGACCGGGAAAT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AGTTAAAAATTGTCGGTTTTTGCCGTCCGTATC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TATGCGCAGCTGGCCTGTCTCTACCGCCTGCATT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCAAGCCACTCAGGCGGGGTATGGGATGAGTGG
GTCGCTCCCTACAGGGGGCGTGGATTGAAATG	CCACTACCACCACATTCCGGGTCAATGAATGGGTC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTGGATATCGTATTTTGCGATGTATGCGGCCACCG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCCTTTGCTTGCAGGTCCTGGACAATTTCCGGC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGATCAATGGTGCTCACTCTATAAAATCACTCG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ACGTTGCAGCCAGTCGCCGATTGCGGTCCCCTGCG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCAAGCCACTCAGGCGGGTTCACATGCGCGGCAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTTCTTTGCCATTTTTTCATTCCTCCTTGTTGTT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCCACTACCACCACATTCCGGGTCAATGAATGGGTC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGATCAATGGTGCTCACTCTATAAAATCACTCG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCCAGTACATCGGTCACGTCGGTTATGACGTCTATC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AAGACGCCTACCAGTTAATTGCGGTCGATACGGA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTGTTTGAATGCACGGGACTGACTGAATACTGG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGGTGCATCCTTGAGTGCTTCAATATGGTGCAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGCCGGAGGACCTGGATACAGCTATCCAGCATTA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGCAATGGCAGGGAGCCTTAATCTTTCCCACTTT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CATTCCTCCATGCTCCACCCCGTCCACGCTTGTA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTTTAAATACGCGGAAACATCCCCATAGTTTGCAG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTCCTCCAATATGTATAGATCGTCAACCTTCACCC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGTTTGCTGTATTTGCGATCCCTAGGATCATCAA
GTCGCTCCCTAATGAATACTTGCTGAGCAAAC

>NZ_CP010525|4|5|710677-711834|CRISPRCasFinder
	CGCCGACAAATACAAATGAATTTCACTCGTCAAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCAAGCGGAAAGCACGTTGGCAAATGGGCGGT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGGAACAGTTAACGTCAGACAATTTACAGGGCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CCAAACGATCAGGGATAAAGTATGGGATGAGTGG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCTAATTCAACTAATGAACCGTCATCGTATCTGCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTCCCGCTGCTGGTTGATCAGCTTTTTCTGTTCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AGACGACAAATACGACTTACTTTGGTACAAGTTAT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TACATCTGGCACATACACGTTAAAGCTGGACGAGC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGGGTCAAAATCCAAAAGGTTTAAAGCATCGCTA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTCTAGCGTTATAACCGGGCGGTCTGGCATTTTGCC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGCGCTATGCTACTGGAATAGGGACATTGCCAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTAAACCGTGACAAGCAAAATCCGAAACACGACAA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CCAAGCTCGATATAATAATCAGCAAAAGCCTGCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GTAGACAATGCGTTGTAATTCCGAGTCAAAAAGT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GAACTTAACGACGGAATCGAACTCGACAGCGACG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCACCATGCTCATCGGGCAAAGGAAAACATCCT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GTTGCAGAACAAGGCTTTGATGGCATCGATTATA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CCGTCATCAATTTTGCACCGGATTGTGCATCCTG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AGGCAGATCACCCGGATCTTTTGGACCGGGAAAT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AGTTAAAAATTGTCGGTTTTTGCCGTCCGTATC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TATGCGCAGCTGGCCTGTCTCTACCGCCTGCATT
GTCGCTCCCTACATGGGGGCGTGGATTGAAATATCAAGCCACTCAGGCGGGGTATGGGATGAGTGGGTCGCTCCCTACAGGGGGCGTGGATTGAAATGCCACTACCACCACATTCCGGGTCAATGAATGGGTCGTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTGGATATCGTATTTTGCGATGTATGCGGCCACCG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCCTTTGCTTGCAGGTCCTGGACAATTTCCGGC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGATCAATGGTGCTCACTCTATAAAATCACTCG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ACGTTGCAGCCAGTCGCCGATTGCGGTCCCCTGCG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	ATCAAGCCACTCAGGCGGGTTCACATGCGCGGCAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TTTCTTTGCCATTTTTTCATTCCTCCTTGTTGTT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCCACTACCACCACATTCCGGGTCAATGAATGGGTC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGATCAATGGTGCTCACTCTATAAAATCACTCG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	GCCAGTACATCGGTCACGTCGGTTATGACGTCTATC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	AAGACGCCTACCAGTTAATTGCGGTCGATACGGA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTGTTTGAATGCACGGGACTGACTGAATACTGG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CGGTGCATCCTTGAGTGCTTCAATATGGTGCAC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGCCGGAGGACCTGGATACAGCTATCCAGCATTA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	TGCAATGGCAGGGAGCCTTAATCTTTCCCACTTT
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CATTCCTCCATGCTCCACCCCGTCCACGCTTGTA
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTTTAAATACGCGGAAACATCCCCATAGTTTGCAG
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT	CTCCTCCAATATGTATAGATCGTCAACCTTCACCC
GTCGCTCCCTACATGGGGGCGTGGATTGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_035183668.1\|706151_707012_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|187820
NZ_CP010525.1\|WP_026684593.1\|707001_707658_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|273040
NZ_CP010525.1\|WP_026684953.1\|714607_715909_+\|cation:dicarboxylase-symporter-family-transporter	unknown	unknown	gnl\|CDD\|183075
NZ_CP010525.1\|WP_026684595.1\|708696_708987_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP010525.1\|WP_035183676.1\|712097_712517_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP010525.1\|WP_035183662.1\|703529_704249_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|273847
NZ_CP010525.1\|WP_035183665.1\|704249_706130_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	pfam09709_cas8c_CAS-I-C	gnl\|CDD\|187887
NZ_CP010525.1\|WP_014097192.1\|695703_696198_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|311556
NZ_CP010525.1\|WP_035183657.1\|696456_697044_-\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|380315
NZ_CP010525.1\|WP_026684589.1\|700905_703332_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_CP010525.1\|WP_017551460.1\|719909_720332_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035183689.1\|724328_725018_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NZ_CP010525.1\|WP_026684954.1\|716285_717431_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|236506
NZ_CP010525.1\|WP_035183679.1\|719012_719894_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035183678.1\|713287_713911_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP010525.1\|WP_014097217.1\|721251_722787_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP010525.1\|WP_035183658.1\|697193_700433_+\|SNF2-helicase-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|377999
NZ_CP010525.1\|WP_014097216.1\|720356_720965_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_017551458.1\|718075_718990_+\|DUF1002-domain-containing-protein	unknown	unknown	gnl\|CDD\|377628
NZ_CP010525.1\|WP_026684594.1\|707654_708686_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_035183668.1\|706151_707012_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|187820	cd09689, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csd2 family.	8.52043e-135
NZ_CP010525.1\|WP_026684593.1\|707001_707658_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	4.39067e-31
NZ_CP010525.1\|WP_026684953.1\|714607_715909_+\|cation:dicarboxylase-symporter-family-transporter	gnl\|CDD\|183075	PRK11283, gltP, glutamate/aspartate:proton symporter; Provisional.	0
NZ_CP010525.1\|WP_026684595.1\|708696_708987_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.60661e-36
NZ_CP010525.1\|WP_035183676.1\|712097_712517_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.4066e-15
NZ_CP010525.1\|WP_035183662.1\|703529_704249_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|273847	TIGR01876, cas_Cas5d, CRISPR-associated protein Cas5, subtype I-C/DVULG. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum. This family belongs to a set of several Cas protein families, one each for a number of different CRISPR/Cas subtypes, that share a region of N-terminal sequence similarity modeled by TIGR02593. This family represents the Dvulg subtype of CRISPR/Cas locus.	6.65501e-99
NZ_CP010525.1\|WP_035183665.1\|704249_706130_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	1.04323e-179
NZ_CP010525.1\|WP_014097192.1\|695703_696198_-\|DoxX-family-protein	gnl\|CDD\|311556	pfam07681, DoxX, DoxX. These proteins appear to have some sequence similarity with pfam04173 but their function is unknown.	0.000763054
NZ_CP010525.1\|WP_035183657.1\|696456_697044_-\|nitroreductase-family-protein	gnl\|CDD\|380315	cd02138, TdsD-like, nitroreductase similar to Burkholderia pseudomallei TdsD. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.	1.13575e-75
NZ_CP010525.1\|WP_026684589.1\|700905_703332_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	2.27482e-82
NZ_CP010525.1\|WP_035183689.1\|724328_725018_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	2.85744e-67
NZ_CP010525.1\|WP_026684954.1\|716285_717431_+\|metallophosphoesterase	gnl\|CDD\|236506	PRK09420, cpdB, bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.	4.23414e-155
NZ_CP010525.1\|WP_035183678.1\|713287_713911_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	4.50476e-69
NZ_CP010525.1\|WP_014097217.1\|721251_722787_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.11354e-19
NZ_CP010525.1\|WP_035183658.1\|697193_700433_+\|SNF2-helicase-associated-domain-containing-protein	gnl\|CDD\|377999	pfam08455, SNF2_assoc, Bacterial SNF2 helicase associated. This domain is found in bacterial proteins of the SWF/SNF/SWI helicase family to the N-terminus of the SNF2 family N-terminal domain (pfam00176) and together with the Helicase conserved C-terminal domain (pfam00271). The function of the domain is not clear.	3.63245e-101
NZ_CP010525.1\|WP_017551458.1\|718075_718990_+\|DUF1002-domain-containing-protein	gnl\|CDD\|377628	pfam06207, DUF1002, Protein of unknown function (DUF1002). This protein family has no known function. Its members are about 300 amino acids in length. It has so far been detected in Firmicute bacteria and some archaebacteria.	4.74261e-82
NZ_CP010525.1\|WP_026684594.1\|707654_708686_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0

>NZ_CP010525.1|WP_026684595.1|708696_708987_+|CRISPR-associated-endonuclease-Cas2
MLVVITYDVSTLTGAGQKRLRKVAKVCQNYGQRVQNSVFECFVDATQFASLKIELSNIIDPDEDSLRFYQLGNNYKNKVMHIGAKPSLDLEDPLIF
>NZ_CP010525.1|WP_026684594.1|707654_708686_+|type-I-C-CRISPR-associated-endonuclease-Cas1
MKKLLNTLFITQPEVYLSLDGDNIVLLKEKEQLGRLPLHNLESVVAFGYTGASPALMGYCAERNISLIFFTMNGRFLARVIGKSRGNVVLRKKQYRISDDEIASVQIARNFIIGKIYNQKWILERMTRDYPLRIDVTQFKDVSRFLSAIIKQVRLCDSLETLRGLEGQAAINYNKLFDQMILQQKDDFFFHHRSRRPPLDNVNAMLSFAYTLLANDTASALEGVGLDAYVGFMHQDRPGRVSLALDLMEELRGVYADRFVLSLINTKVINKDDFLKKENGTVIMTDEARKKFLKAWQNKKQEKITHPFLGEKISWGLVPHAQALLLARFLRGDLDEYPPFLWK
>NZ_CP010525.1|WP_026684593.1|707001_707658_+|CRISPR-associated-protein-Cas4
MAFDEDEYLMLSGIQHFQFCKRQWALIHIEQAWEENVRTVEGQNIHQKTDSPFIREKRGSKLIVRAMPIKSNELKLTGICDVVEFVKDKNGVEIYGNEGKYIPYPVEYKRGKPKKNDSDILQLVAQAMCLEEMLLCEVNKGYIFYNEIKRRIEIPITLDEKNKVRKIAAEMQDYYQRRYTPKVKTGPFCNQCSLQNICLPNIIRKRAVSSYIEGKINE
>NZ_CP010525.1|WP_035183668.1|706151_707012_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MPALDHKIDFAVVLSVTKANPNGDPLNGNRPRQNYDGYGEISDVAIKRKIRNRLQDMGESIFVQSNDRKNDSYNSLKERADANPELNKIFKSKDGSGETFAAIACQEWIDVRSFGQVFAFKGSGNKGVSVGVRGPVSIHTATSVSPIDITSMQITKSVNSEPGKDRGSDTMGMKHRVDFGVYVFYGSINPQLAEKTGFSNEDAEKIKQALVTLFENDASSARPEGSMEVKKVYWWEHQSKLGQYSSAKVHRSLAVTPLVDNPKTFEDYEITLNELSGLKVDVIDGI
>NZ_CP010525.1|WP_035183665.1|704249_706130_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSWLLNLYETYQANEEQVGKIEKKRNDQEYTLLPVSHTTQTAHLEVQVTEDGNFYYAEVINDKKDAVTLIPCTEESSSRAGKKIAPYPLHDKLIYVAGDFVAYGGKIEEPFSYYIQQLGEWANSPFSNAKVQSIYAYLKKKQLIHDLVEAGILFLDNNGQLIDKWDSKYGDKPPLYSTVTGSVESTFVRFTVYSPEKILTKVWKDPEMYESFIKFYNQHLSDRDLCYVTGEFLPSTERHANKIRNSGDKAKLISANDSRGFTYRGRFTESKQVASISYKASQKAHNALKWLINKQGKIIDNRVFLVWENGGNEVPSVTEDSYDITSLDPFANGSNPKIAFTNQEFAREFSKAMDGYKSNLSTEASINILVLDSATTGRMAVLYYRNLNKEIYFKNLVKWHTTCAWLHRYRKNEDNQPISFFGAPSTKDIAFAAYGPNASDKVVKGLMERMLPCIVEGRRIPTDIVRSALRRASNPVALEKWEWEKTLSIACALINKEEGYNLALDKENTNRDYLFGRLLAIADVLERNALDSGENRATNAIRYMNAFSQHPARTWGTIQASLQPYQVRLGKKGTYYAMLIDEVASKLKYEDFNDRPLSGKFLLGFYSQRYDLYQKKDTSTVGQTKE
>NZ_CP010525.1|WP_035183662.1|703529_704249_+|type-I-C-CRISPR-associated-protein-Cas5
MRNSIEFEVYGKYALFTDPLTKMGGEKLSYQIPTYQALKGIVESIYWKPTILMIIDDLRVMNPIKMESKGVRPIEYNGGNTLANYTYLRDVRYKVRAHFIFNPHRPDLAFDRNEHKHHNILKRSLKAGGRRDIFLGARECQGYVEPCVFEEGEGYYDQTEEVYFGTMVHGINYPDETGRNEMEVRLWNPVMKNGVIHFIRPDECKLVRRVAEMEMKAFTKDNVESADVLLKELERGGEL
>NZ_CP010525.1|WP_026684589.1|700905_703332_+|CRISPR-associated-helicase/endonuclease-Cas3
MEYIAHIRESDKKVQTVEEHLLAAKELAETYGEKIGVKHITGLAALLHDLGKYTSAFRNYVLEAVNNPDHPPKRGSVDHSTAGGKLLFKMFHSGKASPHKALLAEIVGNAIISHHSYLQDFISPEMDLKYLNRVDSKEIDEFETAKENFFEKVMSPTRFSSYVNQAEIELKNFIMKDASKTLTHKMMFLTKYIFSALIDADRTNTRLFEENKPEKEQFSVSKLFNQYYEKLLLTLDSYKENSSANARINRLRSEMSEQCDAFAEKPSGIYTLSIPTGGGKTFASLRYALKHAQLYNKKRIIYIVPFTTIIEQNAEEVRKVLQDDVNILEHHSNVVEDADENDEQQDGIMSVQQRLKLAKDNWDVPIIFTTMVQFLNVFYAKGSRNIRRLHNMSEAVLIFDEVQKVPVPCISLFNEALNFLKTYCHSSILLCTATQPALNYVEHQLQVSPNPEIIRGLDNVIDAFKRVEIVDRATDETFNTEKLANFIEKRMTEVSSVLVILNTKGVVKKLYEHLNSNDNNINIFHLSTSMCAAHRNQILEEVRHCLDAGKKVICVSTQLIEAGVDVSFECVIRSLAGLDSIAQAAGRCNRHGEKETGFVYVINHEEENLSRLPEIKKGKETSKRIFIDLKNTPSIYNGNVLSIQAMEKYFKEFYTAFDANLDYNVPSLQKNMVEMLTTDPNNYSYVRAYCSNTKKKYPLFLSSSFYTAAEKFRVIDDKTTSVIVPFGKGNDVIAELSSNATIEDLSKLMKKAQQYTINLYSQELGKLERNGGIISLFDGKILALKEGAYDHEFGLNVENDSELDFLSI
>NZ_CP010525.1|WP_035183658.1|697193_700433_+|SNF2-helicase-associated-domain-containing-protein
MVDYLLFEEDVEMMYSPAIFHRGMSYYMQGRVKKLIFNKDSTWTAIVKGSKTYYVTIYYDEEFGEFSNVCTCPAHEQYGECKHEVAAMLAIANGEEEAAEPNIGDVSETHQHMKTLQLMNIFSGLQQSMMETKHNAARKPLRLEYFLKATNVSGFGSDHFLTIEIKIGPGRTYVVRDIKDFLGNVSRGNPHAFTKNFIYDPDEHAFEEEDKEIVEMLLYMLSTQQLYEASMDRWYRFALERELVIPPFIARPLIKKLANRKCKFKYERYAADSIVLHQEEELPLSFRLDGNRQDGPGFLLQLKSLKDLLLFEQYGLAFYKGGFYELSPDQLTLLAALEDFYKKSGDEVEVQQEQMSPFLSNVLPGLKRIGKVRLANEIKGKIVQPKLQTKIFMDNEDEKITLRIEHHYGSRVIDPFTDEETPDDDKILLRDVEKEQKIMMMIEQSPLKYNGKQLYLEDDEEALYEFIFTILPQLEEEVEVYIAGGIKSYFQTSRYTPVTSVDMDTSGNFLEVNFDMDGIDEEEIRNVLRSVIEKKRYYRLPDGAFVSLESDAFEHIGQLLEELHVPKKELEDNRLKVPLYRGLQVEELMKTRDKYAVKFGKAFRKLVQQLKNPEDTDFELPKGLEAKMRDYQVTGFQWFKSLAFYRLGGILADDMGLGKTLQSISYMLSEKEANPDIKPFLVVAPASLIYNWKSEIEKFAPGLSSMVIAGTPSERKAFFEAGELPDVLITSYPTLRQDIEEYEKIEFDTLILDEAQAIKNYATKTAAAVRNVQAGRRFALSGTPIENSIDELWSIFQAVLPGFFPPLPEFRKMEQEKISRMVRPFILRRVKKDVLKELPDKIETNHLSELTKPQKELYLAYLDRIRHETAQTLAEGDFNRNRIKILAGLTRLRQLCCHPSLFVENYRGDSGKLEQLVELAHTAIENGKRLLIFSQFSSMLQMIRTRLSDEGIDSFYLDGQTPSRERVEMADRFNSGEKNVFLISLKAGGTGLNLTGADTVVLYDLWWNPAVEEQAAGRAHRIGQKNVVQVIRLIARGTIEEKIYELQQKKKELIEQVIQPGETMLNSLNEEEIKELLGM
>NZ_CP010525.1|WP_035183657.1|696456_697044_-|nitroreductase-family-protein
MVKTLSPREAQYDIDPVYLERWSPRSFLEKEVPEEVLLSLFEAARWAPSAYNHQPWRFILARTKEDREKVLSFLGEYNRMWCKNVPVFALILSKTENETGPIRSHAFDAGAAWGYLSLEAVRKGLATHPMTGFDFEKAREVLNIPADYAIDALIAIGYQGEKEALPPSLQERETPSARRPVKESVFEGSFGNPVK
>NZ_CP010525.1|WP_014097192.1|695703_696198_-|DoxX-family-protein
MKWYHDSKVSIIWAIIRIWLGIQWLEAGLHKLTGGFDAAGFLKGALAKTAGENAEVQGWYAAFLTHFAIPNVHVFNVLIPYGEVLVGLGLIVGLATIPALIAGAFMNLNFMLAGTTSTNPVLYTVAIILLFTGSASYYWGLDRIAIPAIKNYFQNRAHKPRPAH
>NZ_CP010525.1|WP_035183676.1|712097_712517_-|helix-turn-helix-transcriptional-regulator
MADHGNENMENVKEIFAARLKKVRTAQGYSQPELAKKVGVSDRNISNYETGYSFPSIKVLYRISQVLKVSIDYLLGLTNHAGLKTNEAVSNPEKKLLETLSHEPDLYQMMLKDPEKMANRIYQTWNLIRELDDEDDRNT
>NZ_CP010525.1|WP_035183678.1|713287_713911_-|histidine-phosphatase-family-protein
MTLFYFVRHGQTEWNADRNRYCGRSDIGLSQTGVRQAELAAGFLKDIPFNAVYASTLGRATRTAEILVEGRNLKIHQDPRLVETDFGAWEGERQEDFSVKYADNWEAWLKDPGATHAGYTGETAIQVYNRVRACIDELVEKHPEETVLVVAHSMAIRFFVAGTLEVPYKNYRMIPQDNTGITIYKETPENAGFLAINLNTHLSSIKN
>NZ_CP010525.1|WP_026684953.1|714607_715909_+|cation:dicarboxylase-symporter-family-transporter
MKRVSLAWQIFIGLILGIAIGGIFHGNDTVAHILQPFGDFFLRLIKMIVIPIVVSSLIVGVAGAGDMKQVGKLGLKALIYFEIVTTIAIVVGLLAGNLFHPGTGVDMGSLAKTSISSYVETTKETQHNGIVDTILSIVPTNLFESLSQGNMLPIIFFSVMFGIGVAAIGEKGKPVLRFFQGVSEAMFYVTNLVMKVAPIGVFGLIGVTVTQFGLKSLIPLSKLVFTVYGTIIFFVVVVLGLIAWLFRVNIFNLFKILKDELILAYSTASSEAVLPRLMEKMEKFGCPKSITTLVIPTGYSFNLDGSTLYQSLAALFIAQMYGIHMSIGAQISLVLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPLEGLAFIAGIDRILDMARTACNVVGNTLATIIVSKWEGKYDKEKAEAYLAEISGGGHDSKDHKYVTES
>NZ_CP010525.1|WP_026684954.1|716285_717431_+|metallophosphoesterase
MDKKMLLWVAVLSLALFPRTEHADAAFWFQSKRATVDLRLLETSDLHGYMLNYDYAARTEAETYGLALTASLIAAERKTAKNTMLFDDGDLLEGNEMAAYVARRPLKKGEIHPFIRVMNHLNYDAATVGNHDFHYGLDFLKQTINGAKFPFVNANIYYNFEKNDTDDQNFFKPYVILDKKVEDRSGHHHHLKIGVIGFVTPSVIEWEKPSLGGKVKAKDILHTAAWFVPRMKAEGADLIIALAHCGVDPAAKQPFYTGDAVYLLSEVKGIDAILFGHQHRVFPSEFFAGVPGVDIRKGTINGVPAVMPGKWGSHLGVISLTLEKKGEKWEMTQAQSEAKPVYAIHNQQAKSIVRPDPDIVRMTAELQKNVLGSKFTLYSRN
>NZ_CP010525.1|WP_017551458.1|718075_718990_+|DUF1002-domain-containing-protein
MLKRLGWIWFIAMIALGFTMNGVAKASGDNSTVIDEKYGKPIVATGAALSASQKAEVEKELGVDDANNVEEITVTGDDLVHYIPDGNRNSNMYSSAKITRTDSGGIQVNIVTPENITEVTADMYKNALLTAGIKNAEVEVASPLKVTGHSALVGIYKAYDNSDKSGDKLNSDRTEVASQELSVATDLAKKEGLSNDQVTQLLTEIKQEIANQHPATKEDIEKIVDDKLKDLNINLSDSDRQLLYDLFDQMRKLNINFGSVKSELSSLSDKLSDKINKAAGDKDFWQSVKDFFQNIFDAIRGLFQ
>NZ_CP010525.1|WP_035183679.1|719012_719894_-|hypothetical-protein
MVRQVKKTKSFLLTAAFIAFNFCFFTNISVAESPVTDGFIIEADRVEGAMLPPGITAGDTATKQNQVMLRLQYADVTIYGLKITKVLQTPEGPVTIHMNAPGPIQLKNMRVDATKVNFGGIYVPEKARQIGMKNVRLVAHQQLADNADLPGLNLSMETGAADIDTSGSDEETLRKQADQLTQLLQGGTPEKNKEEKNDKSDTADKAKDGTQDKAKTEKQDTEKHNDAKTDGKVTDQNKNKESENTDDTKLDNTGTEPASGQETEKNRTTTKTAQDQGSTDQNVQQKEGSSAGN
>NZ_CP010525.1|WP_017551460.1|719909_720332_-|hypothetical-protein
MGKFHMFRMKFRNWRRSRPFWGATFTLLSGMIILYVPVQLLEIAAAPGSMVSIGLIFGGLIFLIGGMGYFFPKFNMVFGILAIFLSVLSIMGAMGGFFIGTLLGIIGGSLSVSWRVIRQEEVPAGVGPMEEIAAGSAEER
>NZ_CP010525.1|WP_014097216.1|720356_720965_-|hypothetical-protein
MNEGALVLQGQGRTSKKWFFTALLSGLIFLGGLLAVLGINGVAVAATVGGIGKFNVSFKQMQGTGFKLYGSLYGDPSKGEDHVKPVFVNEIDKVTIQDLVISKDVKIPVLGDYQVKITAGDGNTPVHLNGLIQKAALVQGDAVFTNMNISENYVTADDPQAASKAFTQGADTLTIKNGSLDTHYLFQKVANLPNLKVQFVKK
>NZ_CP010525.1|WP_014097217.1|721251_722787_+|helix-turn-helix-transcriptional-regulator
MSLSLNAHMDMVMKHGVDLLRSHQQQIIAECTGILQYLRETHKGSADAFEFAFNCFVAFFRSGQQSVETLIDDIRSQWVKEFHRPPEPHVLIFILTLIENSVHKAIKESTTRSFHLHPSVQYLFSKICEEMLLISKQETFQMDSFCEQLTKSEQLRIEWIARVSHVDGGYRLKKVIGMEENAIDSGLFERTDPSWFWLSEALLKRTPRRKPDERRDVFPVPWKNETLIFCMSDQDVSATIPFLTYAMHLLQMEEERNGKVYAGDQWKDAVILFNEWIMRSQDLNEAIQNIAFGYAQYLPFERCALFRYSQSDAAGFGLFGYHFNNTAIRNIKETIDRFPSISKILLGKGQQVNMVQHFQPLYIPKASEEFPMQYVKEFELESVVVAPIYVPSEGVLIGGAILDQGPGKFFEVDSSTFTALLKFGQSAGELLAKFLKANQWDEKQPELVQLSAREIHILQLLADGASTTEAAEMLHLSEYTVRDYVSSLMKRLHARNRTEAAVKAMRLGLIH
>NZ_CP010525.1|WP_035183689.1|724328_725018_+|N-acetylmuramoyl-L-alanine-amidase
MFKLFLDPGHGGKDPGAEGNGLEEKDITLEIAKQIQDILTNHYQNASVKMSRTTDKFVSLEERTDAANSWGATFFLSIHINSGNGTGFESYIYPKSGSATATYQKTIHQEVVKLNDLKDRGRKTADFHVLRESIMPALLTENGFIDTASDAKKMKKSSWIEDVAQGHVNGLAKAFELKKKSGATYHKVVKGDTVYALSKEYGSTIKEIKKWNNLDDDYTIRVGERLRVK

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Crispr_ID: NZ_CP010525_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_5

874504-874610

Orphan

Consensus_repeat	Method
GGTTCTGAATTTGCCAGCGAAACGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_5

>merge|NZ_CP010525|5|874504-874610|CRISPRCasFinder
GGTTCTGAATTTGCCAGCGAAACGAATGCGCAGGAAGTAAGAAAGCAAAACGCGAAGTCTGCTTCCGGCCAAGGTTCTTTCGGTTCTGAATTTGCAAGCGAAACGAA

>NZ_CP010525|5|6|874504-874610|CRISPRCasFinder
GGTTCTGAATTTGCCAGCGAAACGAA	TGCGCAGGAAGTAAGAAAGCAAAACGCGAAGTCTGCTTCCGGCCAAGGTTCTTTC
GGTTCTGAATTTGCAAGCGAAACGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_014097371.1\|874835_875090_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372951
NZ_CP010525.1\|WP_043052472.1\|863350_864712_-\|transposase	unknown	unknown	gnl\|CDD\|379252
NZ_CP010525.1\|WP_014097376.1\|879930_881400_+\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|181971
NZ_CP010525.1\|WP_035183880.1\|865579_865864_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_014097369.1\|873613_874363_+\|enoyl-[acyl-carrier-protein]-reductase-FabL	unknown	unknown	gnl\|CDD\|236145
NZ_CP010525.1\|WP_035183885.1\|877955_879035_+\|DUF871-domain-containing-protein	unknown	unknown	gnl\|CDD\|377567
NZ_CP010525.1\|WP_035183882.1\|867729_872292_-\|glutamate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236968
NZ_CP010525.1\|WP_014097373.1\|875875_877624_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP010525.1\|WP_026684724.1\|859662_860781_-\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NZ_CP010525.1\|WP_014097368.1\|872416_873331_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176125
NZ_CP010525.1\|WP_014097361.1\|860959_861940_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|224899
NZ_CP010525.1\|WP_035183889.1\|879025_879913_+\|N-acetylmuramic-acid-6-phosphate-etherase	unknown	unknown	gnl\|CDD\|235467
NZ_CP010525.1\|WP_035183891.1\|881399_882269_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP010525.1\|WP_035183893.1\|884270_884651_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_014097379.1\|883741_884020_+\|YqhV-family-protein	unknown	unknown	gnl\|CDD\|378514
NZ_CP010525.1\|WP_014097366.1\|865993_867451_-\|glutamate-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|237213
NZ_CP010525.1\|WP_035183873.1\|862515_863388_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP010525.1\|WP_014097362.1\|862026_862185_+\|small,-acid-soluble-spore-protein-K	unknown	unknown	gnl\|CDD\|285399
NZ_CP010525.1\|WP_014097372.1\|875244_875775_+\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|184219
NZ_CP010525.1\|WP_035183895.1\|884784_886053_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_014097371.1\|874835_875090_+\|hypothetical-protein	gnl\|CDD\|372951	pfam14182, YgaB, YgaB-like protein. The YgaB-like protein family includes the B. subtilis YgaB protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	3.90547e-24
NZ_CP010525.1\|WP_043052472.1\|863350_864712_-\|transposase	gnl\|CDD\|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	4.28122e-20
NZ_CP010525.1\|WP_014097376.1\|879930_881400_+\|PTS-transporter-subunit-EIIC	gnl\|CDD\|181971	PRK09586, murP, PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed.	4.27199e-94
NZ_CP010525.1\|WP_014097369.1\|873613_874363_+\|enoyl-[acyl-carrier-protein]-reductase-FabL	gnl\|CDD\|236145	PRK08063, PRK08063, enoyl-[acyl-carrier-protein] reductase FabL.	6.2166e-156
NZ_CP010525.1\|WP_035183885.1\|877955_879035_+\|DUF871-domain-containing-protein	gnl\|CDD\|377567	pfam05913, DUF871, Bacterial protein of unknown function (DUF871). This family consists of several conserved hypothetical proteins from bacteria and archaea. The function of this family is unknown.	9.33947e-161
NZ_CP010525.1\|WP_035183882.1\|867729_872292_-\|glutamate-synthase-large-subunit	gnl\|CDD\|236968	PRK11750, gltB, glutamate synthase subunit alpha; Provisional.	0
NZ_CP010525.1\|WP_014097373.1\|875875_877624_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP010525.1\|WP_026684724.1\|859662_860781_-\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	9.39498e-155
NZ_CP010525.1\|WP_014097368.1\|872416_873331_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176125	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold. GltC, a member of the LysR family of bacterial transcriptional factors, activates the expression of gltA gene of glutamate synthase operon and is essential for cell growth in the absence of glutamate. Glutamate synthase is a heterodimeric protein that encoded by gltA and gltB, whose expression is subject to nutritional regulation. GltC also negatively auto-regulates its own expression. This substrate-binding domain has strong homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.4486e-54
NZ_CP010525.1\|WP_014097361.1\|860959_861940_+\|metal-dependent-hydrolase	gnl\|CDD\|224899	COG1988, COG1988, Predicted membrane-bound metal-dependent hydrolases [General function prediction only].	2.963e-38
NZ_CP010525.1\|WP_035183889.1\|879025_879913_+\|N-acetylmuramic-acid-6-phosphate-etherase	gnl\|CDD\|235467	PRK05441, murQ, N-acetylmuramic acid-6-phosphate etherase; Reviewed.	2.22063e-178
NZ_CP010525.1\|WP_035183891.1\|881399_882269_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	9.07677e-68
NZ_CP010525.1\|WP_014097379.1\|883741_884020_+\|YqhV-family-protein	gnl\|CDD\|378514	pfam10942, DUF2619, Protein of unknown function (DUF2619). This bacterial family of proteins has no known function.	3.43115e-26
NZ_CP010525.1\|WP_014097366.1\|865993_867451_-\|glutamate-synthase-subunit-beta	gnl\|CDD\|237213	PRK12810, gltD, glutamate synthase subunit beta; Reviewed.	0
NZ_CP010525.1\|WP_014097372.1\|875244_875775_+\|DUF402-domain-containing-protein	gnl\|CDD\|184219	PRK13662, PRK13662, hypothetical protein; Provisional.	7.44715e-130
NZ_CP010525.1\|WP_014097362.1\|862026_862185_+\|small,-acid-soluble-spore-protein-K	gnl\|CDD\|285399	pfam08176, SspK, Small acid-soluble spore protein K family. This family consists of the small acid-soluble spore proteins (SASP) belonging to the K type (sspK). The sspK are unique to the spores of Bacillus subtilis and are expressed only in the forespore compartment of sporulating cells of this organism. The sspK gene is monocistronic and transcription is primarily by the RNA polymerase with the forespore-specific sigma factor, sigma-G. Mutation deleting sspK results in loss of SspK from the spore but had no discernible effect on sporulation, spore properties or spore germination.	6.9293e-19
NZ_CP010525.1\|WP_035183873.1\|862515_863388_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.17426e-68
NZ_CP010525.1\|WP_035183895.1\|884784_886053_+\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.13094e-100

>NZ_CP010525.1|WP_014097369.1|873613_874363_+|enoyl-[acyl-carrier-protein]-reductase-FabL
MANKVALVTGSSKGLGRAIALDLAKDGYDLVINYARSRSKAEEVAAEIEKMGQKALLIKANVGDVKKIKEMFAQIRDTYGRLDVLVNNAASGVERPAMELEDRHWDWTMNINSRALLFCAQEAAKLMEENGGGKIVSLSSLGSIRYIENYTAVGVSKAALEALTRYLAVELAPSICVNAVSGGVLNTDALKSFPNREVLLEDARKHTPAGRMVEVEDMVNAVRFLISDEAFMIRGQTIIVDGGRSLLLS
>NZ_CP010525.1|WP_014097368.1|872416_873331_+|LysR-family-transcriptional-regulator
MIRMELRQLIYFIEVAKREHVTHAADELHVAQSAISRQISLLEAELGVSLFWREGRNVRLTPIGKVFLEHAEKVVLEIDKAKQRMHEFLDPDNGTVRLGFSTGLSVQTFSSLLAQFREKHPGLEYQFVQGTPSYLIRLIENGELELALASPVPDDHPAVSGEILYMEKLMLLFRRDHPLSGQKMIRLAQLKNERFITFREGFSIREILFAACRKSGFEPAIAFEGEDMETIKGLVASGTGVAILPEPALLFNLSEEIVKAEISDMELMRPVGVMIPKKREMAASEKALYTFLTSFYDRLNRFQR
>NZ_CP010525.1|WP_035183882.1|867729_872292_-|glutamate-synthase-large-subunit
MNNQHYGLYRPEFEHDACGIGFYADIKGRASHKIITTALEMLRRLDHRAGKNADGTTSDGAGISMQIPHAFFEAVCSFTLPKKGEYAVGMLFLPHDPDAAEEILNEFRIQAASLGLSVPGVREVPVNPEVLGRQAEESRPHIVQIFVSSSNDNTEEAVFQRKIYILRKLVENKFGSSFYAASFSNRTIVYKGMLSAEQLPLFYIDLQDERFQSALALIHSRFSTNTFPSWERAHPNRMIAHNGEINTIKGNVNWFNAKIELFANELGLDTLKKIQPVINANGSDSAIFDNVLEFLTTNGISLPHAIMMMVPEPWEDNEDLPPYLKSFYEYHSQIMEPWDGPMALEFTNGKQIGAVLDRNGLRPARYYITHDDKIIFASEVGVVDVEPENVKERRHLKPGQLLFVDLEKGALIPSDELKAQVSLEKPYAEHLEDSVIDLEESHFIPAASSLEKNELAYRQTLFGYTYEECTKSIVPMAQEKNEPIGAMGVDTPIAVLSERPQLLFHYFKQSFSQVTNPPIDSIRESYVISTVTWLGPQVSLDGHDDTAHKKIRLEHPFLSTAKFNAILNQGMKTAFLPAYHSPDVTLEEALEQLLKEADEKIREGAEILILSDRAQGHRAVPIPSLLAVSALHQHMIRLGTRPKASIVLDSGEPRDSHHMAALLGYGADAVHPYLALETIQNLIDEGHIDLPYKKASENYLSTLKKSVVKIMSKVGITTMQSYRGAQTFEALGIAESVCDRYFTGTVSQLGGIGLAEIGQESLKRYEKAQELLFQHNKALDPGSELQWRKDGEYHLFNPQMMYTLQQAARTNNKELYRKFSETYHHGPYATIRSLLAIESNRKPVPLDEVEPVESIWKRFKTGAMSYGALSKEAHEALAIAMNRIGGKSNSGEGGEEKERYTPDANGDSRRSAIKQVASGRFGVTSLYLTDADEIQIKMAQGAKPGEGGQLPGSKVYPWIAEVRGSTPGVGLISPPPHHDIYSIEDLAQLIYDLKSANPRARISVKLVAKSGVGTIAAGVAKGLADTILISGHDGGTGASPQTSIKHAGMPWELGLAETHQTLTLNGLRNRVVLETDGKLMTGRDVVIAACLGAEEFGFSTAPLVVLGCIMMRACHLDTCPVGVATQNPKLRAKFMGKPEYVVNYMRFIAEEVREILAECGYRSLDELVGETGLLKVKDEVKNHWKAKQLHFDKLLFKADETPFAVQGKTVQNHKLEERFDSRELNHLSVSVRNRQQTAVTLSVRNTDRAIGTTLGHIITKTYGDEGLPEDFIHIHLHGSAGQSLGAFIPKGLTLNLEGDANDYVGKGLSGGKIVVKPGAGWIRDEEQAIIGNIAFFGATSGEAYIRGTAGQRFCVRNSGVHAVVEGIGDHGCEYMTGGRVAVLGSIGKNFAAGMSGGIAYIYTGAMGEDEVLARINQELVSIEGVDADEDMRELYHMIQKHYQYTGSPVAKRILKNWELSLHQFVKIVPREYKAMMELIQYFLDQQMPLDEARLAAFEYKKSGKHLPEIEKEKAFPTEVK
>NZ_CP010525.1|WP_014097366.1|865993_867451_-|glutamate-synthase-subunit-beta
MRGTTDFIEQKREKPKELDAAKRVATWKEYVQAFPEAKLRTQASRCMECGTPFCQMGELIGRQTSGCPLYNLIPEWNTLAAQGKWEEAYQRLLLTNNFPEFTSRACPAPCEGSCTAGLVSEPVTIKSIERAIIDRAWEEGWIKPRIPLKRNGLKAAVVGSGPAGLTAADDLNQAGYDVTVFEKEDRFGGLLMYGIPNMKIEKQYVERRVDLLQAEGITFKANTEIGKDITLDELESAFDAVLLCIGAEKQRDMDIPGRDLKGIYPAMEYLKANTKHLLDHGENGEPQISAKGKKVIVIGGGDTGADCVATAIRQGCKSVVQFGKHGELPKERPEHEPWPVNPSLFTLDYAYEESFKVFGEDPRQYYIQTTAFHGNENGEVTGLVTVPFSDPRGAEQQVWEADLVLIAIGFQGVDDSKSAGIELQNGLIQTLPGSFQTNREGIFAAGDAKRGASLIVWAMQEGKKAAKEIDLYLSQKDKATCQPSA
>NZ_CP010525.1|WP_035183880.1|865579_865864_+|hypothetical-protein
MAKAAKKRYGWYIHLLIFVLAQLVFFIFYNVSASKNIFNLNDYGKWAVSTLSRIYDWLQIYKSPQFNLIFVIWGAILIIDGLIRMLPKRHSYSQ
>NZ_CP010525.1|WP_043052472.1|863350_864712_-|transposase
MIAKNSLNNQLPNEIKSTFKELNMLKHLRIAGITKSFGFSCAYIFQLIFCMIFENKNWFRMLESKKATDIPAKDTVYRFLNQSTFNWRRFLLSLVASVIGKVSKLTRHDRPKVLILDDSSYDRNRSKHVELLARCFDHASQKMRFYKGFRMLTLGWSDGATFLPVDFSLLSSKKSQINGISENIDKRSSGYKRRKEALQTAPEQIPGMIARAMNSGIDASYVLMDSWFTQQPLIKEITEQGLDVIGMVKKLKQRYFVDGKRVSLDELYRLAKPTSGKKGILRSIHTTQANGVPIKVVFVRNRNKKSDWLAILSTDCTLSDQEIIRIYGMRWDIEVFFKTTKSLLKLQKEFQSRSYDALISHTTIVFARYIVLSWQNRCSVDDRTLGGMFYELCDEIDDLDWAVALQQLVEILEDTLDKSNKKIQQLIKSQLQQWIAGLPNYIKVYLPVSVCES
>NZ_CP010525.1|WP_035183873.1|862515_863388_+|ABC-transporter-ATP-binding-protein
MEYALEIEGLCKSFSKSRFALKNISFSVPYGSITGFIGENGAGKTSTMGAILQTLHIDSGSIKIFGERIAEAKKEINNHIGVVYDAMNFSGNLDVIKLSKVFRYLYHNWDNQEYFNYIELFSLPKKQKINSFSRGMAMKLSIAVALSHGARLLILDEATSGLDPVGREDVLEALLKFVRDQKGAILLSSHITSDIEKVADTLVFIKKGEIVLKTSKNDLLNNYAIIQCKENELNDLRLNGIIAYKNQTDYVDVLVSNKNELPAKFHKKNFSIDDITLLLNFRRLKQVGIP
>NZ_CP010525.1|WP_014097362.1|862026_862185_+|small,-acid-soluble-spore-protein-K
MRNKEKGFPYHHDNVYEGKPRAKAEYASKRADGTTNTHPQERMHASGRRGES
>NZ_CP010525.1|WP_014097361.1|860959_861940_+|metal-dependent-hydrolase
MDTGTHVVMGFALGGLATLDPVVAQDAVHFHSVLIATVLGSQAPDIDTLLKFKNNAVYIRNHRGITHSVPAVLLWPLAITAVLSIFFPGTDALHLWLWSFLAVFLHVFVDIFNAYGTQALRPFSYKWVALGVINTFDPFIFTIHVIGIAAWLFGAQPGPTFLAMYIFIFLYYIARFAARHDVKKAVLARIPDAENIIISPTVRFHQWKIAVRTKDAYYVASAFKSAVTILDKFKRLPVPENEIIEAAKQDKNLSAFLSFSPVYNWQVKELDNGWEVRFTDLRYRKNGHYPFVAVVKLNEDLEITGSYTGWIFNKKKLKKKLDVVPR
>NZ_CP010525.1|WP_026684724.1|859662_860781_-|A/G-specific-adenine-glycosylase
MKNLPIDDFDIKSFQDDLISWFEREQRKLPWREDRDPYKIWVSEIMLQQTRVDTVIPYFRRFMEKFPTIEALADASEDEVLKAWEGLGYYSRVRNLHAAVKEVEEHYGGTVPDTPEEVSKLKGVGPYTAGAILSIAYGLPEPAVDGNVMRVLARILSIWEDIAKPSARKVFEEVVRKLISRENPSFFNQALMELGALVCTPKSPSCLLCPVREHCRAFREGTIDELPVKSKGKKQKQIRLQAAVLEDEDGRILIHKRPDKGLLANMWEFVQVEESTVLPARQVLKDYLGDVFKIEAALETEHFTEIRHVFTHLIWDIRVYHGKILNQVQETNELKCVPPDEIETFAFPVPHQKIWKAFREQAKSEKVKDIKG
>NZ_CP010525.1|WP_014097371.1|874835_875090_+|hypothetical-protein
MMEEFNRLVAQQMDTMDRLLFLQSEMERCNEVKSELLKLQEETMAEDILDEIGRMNKELQEIEKVFESQTVELIRVYHSSKICT
>NZ_CP010525.1|WP_014097372.1|875244_875775_+|DUF402-domain-containing-protein
MGIPAEGDKIQIQSYKHNGHIHRIWEETTVLKGTKSLVIGGNDRTLVTESDGRTWITREPAICYFHADHWFNIIGMIREDGVYYYCNLGSPFVYDSEALKYIDYDLDIKVYPDMTFTLLDEDEYEYHRKKMGYPDVIDHILKRNVDILIHWIRQRKGPFSPDFIDIWYERYLTYLR
>NZ_CP010525.1|WP_014097373.1|875875_877624_+|ABC-transporter-ATP-binding-protein
MGSVKRYMKFVKPYWFQIVATIIIGIIKFTIPLLIPLLIKYVIDDIIGNHGLSPDEKLHKLVWVMSFMLAIFVIVRPPVEYYRQYFAQWTASKILYDIRDRFFTHLQKLSFRFYANTRGGEVISRVMNDVEQTKDFVITGLMNVWLDMTTVLIAIVMMFMMDARLTLISLAVFPFYIFSVKYFFGNLRFLTRKRSQALAEVQGYLHERVQGMAVIKSFAIEDHEQKQFDKHNHNFLEKALAHTSWTAKSFAVVNTITDIAPLFIIFVSGYLVIKGSLTVGTLAAFIAYIDNLYSPLRRLVNSGTTLTQAFASMDRVFELLDEKYDIDDRPDAVECRNVRGNIRFDGVEFRYDDEKEPVLKNINLEIRAGETVAFVGMSGGGKSSLVSLIPRFYDVTKGAVYLDGQDIRTFKVRSLRDKIGMVLQDNILFSESVKSNILLGNPQATDEEVVQAAKAANAHEFIMNLADGYETTVGERGVKLSGGQKQRIAIARVFLKNPPILILDEATSALDLESEHLIQEAIEKLARNRTTLIVAHRLSTITHADRIVLIENGEIKETGTHEQLMAKQGLYYNLFQIQQLDD
>NZ_CP010525.1|WP_035183885.1|877955_879035_+|DUF871-domain-containing-protein
MLGFSIYLNEDWSEEKEACIHRMAAIGMEGIFTSLQLPEDDPSQYRKRLAPLLEAAKRNGMKVMIDISGNVLHHIGLSIDDPARIIESGINGLRIDAGVSWEQVARLSNTMTVGLNASTLTEQDYEQLKQHGANFRRLEAWHNYYPRPGTGLDENWFYEKNKWLKSKGFSITAFAPGDGKLRFPLYESLPTLEIHRHQNPLAAICSLLRDYAVDHAYIGDPGLTPQSRSQIGEFFCHDTILLHATAADPKWRPYIFKNHRNRMDVARDAIRSEQSRTCNQKDDIEPENNIPRNKGSITLDNNLYARYKGELQITKRNLPADAKVNVIGQIAGRDLPLLDFIGSGTRFKMTDNEGENEWT
>NZ_CP010525.1|WP_035183889.1|879025_879913_+|N-acetylmuramic-acid-6-phosphate-etherase
MDLEKLATEQRNEKTMNLDTLSTKEILQLMNEEDQTVPIRVGKELAQIEKVVKAVIRSFNKGGRLIYCGAGTSGRLGVLDAVECVPTFSADPSMVQGLIAGGPAAMTVAVEGAEDSKEMGEEDLKHIHLSEKDTVIGIAASGRTPYVIGALDYAKKAGAVAASLSCNKNAEISRHADIPIEVETGPEVLTGSTRLKAGTAQKLVLNMISTAAMVGIGKVYENLMVDVKPTNVKLVERSKSIIMQASGCSYEAAEQAFYAAGKNVKLAIVMLLTHLSKEEAEEKMAQANGFIRKIV
>NZ_CP010525.1|WP_014097376.1|879930_881400_+|PTS-transporter-subunit-EIIC
MTETKEQRLAREIYENVGGMGNVEKIIHCMTRVRLTIADYSKVNIEGLKAVDGVLGVVEDETLQVVLGPGIVNKVANLMVHEAGVKLGENFPKSAGHKDAGRSNREMAEAKAAEVKAREKAKHKSNGFKRALKSISNIFVPLIPAFVGAGIIGGVAAIFQNIMAADSSALSQNWVSVITTLNIIKNGLYLYLVIYVGINSANEFGATPGLGGVIGAVTMLTGMDPKNPLPNIFNGDALSPLQGGIIGVIFAVWILALVEKRLHKIVPNAVDIIVTPTIALLVIGLFTIFIVMPVAGAVSGALVGSITWVLKVGGAFSGFILGLFFLPMVMFGLHQILTPIHIEMINKTGMTPLLPILAMAGAGQVGAAIALWIRCRKNKKLVQLIKGALPVGIMGIGEPLIYGVTLPLGRPFITACIGGGIGGAVIAGIGNIGAIAIGTSGIDLIPLIAHGRWLGYIAGLVAGYIGGFVATYFFGIPKDAMKETDADRE
>NZ_CP010525.1|WP_035183891.1|881399_882269_+|MurR/RpiR-family-transcriptional-regulator
MELDENIILQIKSKLTSLSKSEKKLGEYILSHAVETVNDNTSELAKKAGVSPATVVRFCRSIGLSGFSQLKIRLYADASGGLDREIYTDITPNEDIAMIADKLALRFNQSITQTANLLETSCIEKITAMVDKSPAIYVYGIGASHVAAEDFTHKFSRIGKPVVHTLDHHLLGSSLINASKDCMFVAISNSGETNEAIKLTQIAKQNGLFTVGITQKRDSTLASIVDAPLIHHGGEAVLLRSAATTSLAAQLFTIDVLYFAYVAKHYHEIMGRLKNSKINIQTFFRKENN
>NZ_CP010525.1|WP_014097379.1|883741_884020_+|YqhV-family-protein
MLWLIEKYVLSMAALRLISGMIEISAAILMLKYNQVEKALLINSSLAIVGPVVLITTTAIGVIGISDKISFAKMLWILAGVGCILYGIKSNG
>NZ_CP010525.1|WP_035183893.1|884270_884651_-|hypothetical-protein
MKLFMEYILEEIEKIGVQQGYRVSLSQKIDEQNYIRGVMQFFDSGFDIYYALIFSFPESHPKLQYTFWVLNQTGNRAVIEKDGSGEKMMETVKETALKEIHVNLMEGGEIRHLLKEIKQTIGTCPQ
>NZ_CP010525.1|WP_035183895.1|884784_886053_+|MFS-transporter
MASKQPSVMTVAAIGSIPLIMTLGNSMLIPVLPKMQSELHLTSFQASLTISVFSIVAAVFIPVLGYLSDRFSRKAVILPALFLYGAGGILAGIAAALFSHAFAWILAGRTLQGIGAAGTAPIAMALTGDLFKGDKESRVLGLVEASNGFGKVLSPILGALIALLVWYGTFFAFPVVVVVSIFLTWVFIKEKPKKKEPPGLGKYVKGLAGVFKDDGRWLCTAYLAGATCLFTLFGILFFLSNVLEKSYKIDGVMKGLILAIPLLVMCTTSYITGSKIGKNQRLMKKLIVTGFCLMTLSYALLTFFRGLFLFIPVLAIGSLGTGLILPCVNSFITNAVGKEKRGFVTSLYGSVRFLGVAVGPPVFGRLMAWSRPGMFISIACFTFAVGLLSLLLIRPQTEKGSSGGEEKKKRSRHTILEPVGGR

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Crispr_ID: NZ_CP010525_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_6

1122639-1122726

Orphan

Consensus_repeat	Method
TCGACAACAATTAGCGCCCATGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_6

>merge|NZ_CP010525|6|1122639-1122726|CRISPRCasFinder
TCGACAACAATTAGCGCCCATGCATGCAGCGCCATCAGTGGATTGGCAAAGACAAAAAAGAGAGGTCGACAACAATTAGACGCCCATG

>NZ_CP010525|6|7|1122639-1122726|CRISPRCasFinder
TCGACAACAATTAGCGCCCATGC	ATGCAGCGCCATCAGTGGATTGGCAAAGACAAAAAAGAGAGG
TCGACAACAATTAGACGCCCATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_014097572.1\|1113852_1114062_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP010525.1\|WP_014097578.1\|1116599_1117949_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|184504
NZ_CP010525.1\|WP_035184190.1\|1119780_1120029_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_014097581.1\|1120985_1122455_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143449
NZ_CP010525.1\|WP_014097573.1\|1114327_1114714_+\|general-stress-protein-13	unknown	unknown	gnl\|CDD\|181215
NZ_CP010525.1\|WP_043052483.1\|1134745_1136347_-\|FGGY-family-carbohydrate-kinase	unknown	unknown	gnl\|CDD\|198356
NZ_CP010525.1\|WP_014097576.1\|1115589_1116060_-\|GyrI-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|226231
NZ_CP010525.1\|WP_017554802.1\|1127197_1127668_+\|divergent-PAP2-family-protein	unknown	unknown	gnl\|CDD\|376897
NZ_CP010525.1\|WP_035184188.1\|1118066_1119068_-\|potassium-channel-protein	unknown	unknown	gnl\|CDD\|369572
NZ_CP010525.1\|WP_013858393.1\|1124367_1125591_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NZ_CP010525.1\|WP_035184216.1\|1131078_1133130_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NZ_CP010525.1\|WP_014097574.1\|1115029_1115227_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_014097577.1\|1116212_1116443_-\|DUF378-domain-containing-protein	unknown	unknown	gnl\|CDD\|225066
NZ_CP010525.1\|WP_035184194.1\|1120041_1120971_+\|ornithine-cyclodeaminase	unknown	unknown	gnl\|CDD\|236313
NZ_CP010525.1\|WP_035184211.1\|1129085_1130180_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133022
NZ_CP010525.1\|WP_035184213.1\|1130172_1130859_+\|glycerol-acyltransferase	unknown	unknown	gnl\|CDD\|153244
NZ_CP010525.1\|WP_035184209.1\|1127946_1128729_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NZ_CP010525.1\|WP_017550147.1\|1138050_1139214_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226669
NZ_CP010525.1\|WP_035184196.1\|1122982_1124149_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NZ_CP010525.1\|WP_026685163.1\|1133402_1134551_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380483

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_014097572.1\|1113852_1114062_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.41172e-11
NZ_CP010525.1\|WP_035184209.1\|1127946_1128729_-\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	2.85402e-103
NZ_CP010525.1\|WP_014097578.1\|1116599_1117949_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|184504	PRK14097, pgi, glucose-6-phosphate isomerase; Provisional.	0
NZ_CP010525.1\|WP_014097581.1\|1120985_1122455_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143449	cd07131, ALDH_AldH-CAJ73105, Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like. Uncharacterized aldehyde dehydrogenase of Candidatus kuenenia AldH (locus CAJ73105) and similar sequences with similarity to alpha-aminoadipic semialdehyde dehydrogenase (AASADH, human ALDH7A1, EC=1.2.1.31), Arabidopsis ALDH7B4, and Streptomyces clavuligerus delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH) are included in this CD.	0
NZ_CP010525.1\|WP_014097573.1\|1114327_1114714_+\|general-stress-protein-13	gnl\|CDD\|181215	PRK08059, PRK08059, general stress protein 13; Validated.	2.28587e-67
NZ_CP010525.1\|WP_043052483.1\|1134745_1136347_-\|FGGY-family-carbohydrate-kinase	gnl\|CDD\|198356	cd07778, FGGY_L-RBK_like, L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is composed of a group of putative bacterial L-ribulokinases (RBK; EC 2.7.1.16) and similar proteins. L-RBK catalyzes the MgATP-dependent phosphorylation of a variety of sugar substrates. Members of this subfamily belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.	0
NZ_CP010525.1\|WP_014097576.1\|1115589_1116060_-\|GyrI-like-domain-containing-protein	gnl\|CDD\|226231	COG3708, COG3708, Uncharacterized protein conserved in bacteria [Function unknown].	3.69699e-17
NZ_CP010525.1\|WP_017554802.1\|1127197_1127668_+\|divergent-PAP2-family-protein	gnl\|CDD\|376897	pfam02681, DUF212, Divergent PAP2 family. This family is related to the pfam01569 family (personal obs: C Yeats).	2.12185e-63
NZ_CP010525.1\|WP_035184188.1\|1118066_1119068_-\|potassium-channel-protein	gnl\|CDD\|369572	pfam07885, Ion_trans_2, Ion channel. This family includes the two membrane helix type ion channels found in bacteria.	2.15981e-12
NZ_CP010525.1\|WP_013858393.1\|1124367_1125591_-\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	2.3453e-31
NZ_CP010525.1\|WP_035184216.1\|1131078_1133130_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	1.30325e-56
NZ_CP010525.1\|WP_014097577.1\|1116212_1116443_-\|DUF378-domain-containing-protein	gnl\|CDD\|225066	COG2155, COG2155, Uncharacterized conserved protein [Function unknown].	3.96639e-24
NZ_CP010525.1\|WP_035184194.1\|1120041_1120971_+\|ornithine-cyclodeaminase	gnl\|CDD\|236313	PRK08618, PRK08618, ornithine cyclodeaminase family protein.	1.38935e-73
NZ_CP010525.1\|WP_035184211.1\|1129085_1130180_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	6.11768e-39
NZ_CP010525.1\|WP_035184213.1\|1130172_1130859_+\|glycerol-acyltransferase	gnl\|CDD\|153244	cd06551, LPLAT, Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis. Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).	0.000595739
NZ_CP010525.1\|WP_017550147.1\|1138050_1139214_-\|sugar-ABC-transporter-permease	gnl\|CDD\|226669	COG4214, XylH, ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism].	2.88589e-147
NZ_CP010525.1\|WP_035184196.1\|1122982_1124149_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	1.74701e-63
NZ_CP010525.1\|WP_026685163.1\|1133402_1134551_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|380483	cd01541, PBP1_AraR, ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of AraR is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.85742e-112

>NZ_CP010525.1|WP_014097581.1|1120985_1122455_+|aldehyde-dehydrogenase-family-protein
MEKYLNYIDGEWCEPSTGKFAPVVNPANGKTLGEVAQSAEPDLDRAVQAAKSAQSVWRLVPAPERANYLYKVGELLKQRKEQIARTLTSEMGKVIDEARGEVQEAIDMAFYMAGEGRRQFGDTVPSELQNKFAMSIRVPVGIAGLITPWNFPIAIASWKSLPALVTGNAVIWKPATETPATACAFVKIYEEAGLPKGLVNLVHGSGSVIGEAMVEHPGIGLISFTGSNEVGRKINERAGGLLKRTSLEMGGKNAVIVMDDADLDLAVDGILWGAFGTSGQRCTATSRVIVHKKIKDALEEKLIRRTAELKIGDGLDETVAVGPVINTEALNRIHQYVETGKKEGARLLTGGRILPGKGYYYAPTVFTDVSPEMVIAQEEIFGPVVSIIPVASLEEAIVVNNSVTFGLSSGIFTKDVNKAFQAMRDLDTGIVYINAGTTGAEIHLPFGGTKGTGNGHRDSGPAALDVYTEWKAVYVDFSGKLQRAQIDNN
>NZ_CP010525.1|WP_035184194.1|1120041_1120971_+|ornithine-cyclodeaminase
MLVLNGSDVLKSASMQEMVAAVEEAYHIYEENGYQMPLRTHFTIRNHSVLFMPCSTNEAAGAKIVSVFPDNKDRPVTQGAVLLVDSRNGSMKTLMDGTVLTGLRTGAIGGAAAKYLAPSDAKTAGLIGTGYQGLYQLAGVCTARNIENIFLFNRTPSNIPPFIRRFKTLIPNIPVHIAKSARELAEKADILITATSSATPVLPEEDLYDGKLVIGIGSYQPHMREFPDALLKNLKSIYIDSHDAAKESGDVDSRLKTIPFSKIVTQKVKPDPNTLQVFKSTGMALFDLVAAETVYKKAIQLGIGQMLDF
>NZ_CP010525.1|WP_035184190.1|1119780_1120029_+|hypothetical-protein
MNGKLSFTRLMKDKTPGHERQTVFHRVDEGQNVGPETKELSRYSPQSDKAAGPGPKAASPAAKSFFIMILLCLTYIFTKSLK
>NZ_CP010525.1|WP_035184188.1|1118066_1119068_-|potassium-channel-protein
MFHFFYYRFLRWPIIVRILNLALAVIFVFGLAIHFVEPKTFPTVFDGVWWAVITTATVGYGDLYPVTFAGRVIGIILILSGAGILSAYFVALAGATATRQNAFLEGKAAFTGGKQMVIIGWNERARKVIGQLMELKERQPVVLVDETLESNPYPYDNVYFIKGKPYQDETLKKANVKAAKAVLITSDQHKTETEADMGAVLTLLAVKGLNPDAYCIVEIQTADQVVNAKRAGADEVIQANTQASFVMLNSLISNGMSDTLLSLLNQQEKNHLDFIPVKPKWRNLTVKDLSRQLQKERKILIGIQSGDDTMINPPLDYTITDEEHLFVVLEKDK
>NZ_CP010525.1|WP_014097578.1|1116599_1117949_+|glucose-6-phosphate-isomerase
MTHIQFDYSKALAFFNEHEITYLSEPIRLAHKLLHEKTGVGNDFTGWLTLPKDYDKEEFARIQKAAAKIQNDSDVLLVIGIGGSYLGARAAIEMLNHSFMNVLPKEKRKNPQIFFVGNSISSTYMKDLMDVLEGKDFSINVISKSGTTTEPAIAFRIFNKLLIEKYGEKEAKGRVYATTDRAKGALKTLADAEGYETFVIPDDVGGRYSVLTPVGLLPIAVSGVDIQAMMDGAAKAVDDFSNPEVAENIAYQYAAVRNILYRKGKTIEMLINYEPGLQYFSEWWKQLFGESEGKDQKGIYPSSANFSTDLHSLGQYVQEGRRDLFETVVKVEQAREELTIEKEENDLDGLNYLAGRTVDFVNNKAFEGTLLAHTDGGVPNLVVSIPKTDAYTFGYLVYFFEKACAVSGYLNGVNPFDQPGVEAYKKNMFALLGKPGYEDLKAALEKRLK
>NZ_CP010525.1|WP_014097577.1|1116212_1116443_-|DUF378-domain-containing-protein
MSIVQRIALIFTIIGAINWGLIGFFNFDLVAAIFGDNSAISRVIYGIVGICGLINLGLLFKPDAEVERSTQAKPTR
>NZ_CP010525.1|WP_014097576.1|1115589_1116060_-|GyrI-like-domain-containing-protein
MEIQIVQKHAFNAVGSKWTGTFEQAANGEIKRFFHQFKQKMGKIRHCTDPSVVIGLSYHSQDDEGLFSFYLVREVAYIEAVPEGMTALTVPSYTFAAAKYKGEDVQKAYAELYKWIRKNGYTVFQGQLEHREDYPTSYEPLIDEPELTLYIPLYIE
>NZ_CP010525.1|WP_014097574.1|1115029_1115227_-|hypothetical-protein
MALDVKGEEKAATDVYAKLHKHGDNGDFSGFVFNIGIQNWEEQNEPDWDIPDDFIPLQRNDGDGN
>NZ_CP010525.1|WP_014097573.1|1114327_1114714_+|general-stress-protein-13
MSNYEAGNVYTGKVTGIKPFGAFVALDEETQGLVHISEIKHGYVKDIHDHVHIGNEVKVKVLSVDEENGKISLSIKATEEAPHQDTRKPRRRQGAVKAAEESGEGFNTLRDKLKEWIEKSKREDLIKK
>NZ_CP010525.1|WP_014097572.1|1113852_1114062_-|helix-turn-helix-transcriptional-regulator
MNSFGEKLKFYRELSGMSIEELAVKARIGKHTLEQYETGEQIPTTQTILKLSTVLDVAASVFLEALGKK
>NZ_CP010525.1|WP_035184196.1|1122982_1124149_+|FAD-binding-oxidoreductase
MKNKADVIIVGGGIIGSSVAYHLLADGFAGRIIVFEKDPSYAYASTPRSAGGIRQLFTTAVNIQMSRYSLQVYRNFSKSMTIGSETFEVDLKQRGYLFLATPSMMPHFKKHLKLQHQNGVSPEWLGKKELLGLIPELDTRDLAGGLYCAESGYLDPYTAMQGFIKNAKHLGAEYMYEEVDRFLAEEGRIKGVQLKDGRAFFAPVVVNCAGAWASGLSSKAGLPLPVIPVPRRIFMFDVEKPLAKPLPLTMDPTGVYFRHEGRKIIAGYGEEEKPAIDFSWKRSEFEEQIWPVLAGRIPNFEKVKVERGWAGLYDYNTADHNAIIGEHPEMKGYFVAFGFSGHGMQQAPAVGKGLSDLIRTGKYETIDLTPLRVERFAENDLVTEDAIY
>NZ_CP010525.1|WP_013858393.1|1124367_1125591_-|IS110-family-transposase
MPLFVGIDVSSKNLDACLMDGMGETLATQTVTNNLPGASELRDAILQHAEADDTIQIAMEATSVYSWHPAMFFHEDPELKQRRTKVFTLNPKLVRNFKKAYAEMDKTDPKDAWVIADRLRFGRLPKSVIQSEQYLALQRLTRMRYHLIQSLTREQQVFLNHLFFKFSAFNLEVDTPVFGHAITEFLLEAYSLDEIAQMPLEDLAMYLQTKGHGRFSDPEDLAASIQKAARSSYRLSKCVEDSIDLVLGSSIEIIRHLKRQIKDLDKAIARVLDGIPNTLQTIPGIGPVSCAGILAEIGDIERFDDQAAIAKFAGLFWPRHQSGDFEADDKMLARTGNRYLRYYLVEAANLVRRHEPEYRAFYQKKYREVHKHSHKRALVLTARKLVRLIDALLRNDQIYAPKKKVTR
>NZ_CP010525.1|WP_017554802.1|1127197_1127668_+|divergent-PAP2-family-protein
MFLSYPILSALLGMLVAQIIKVPIHFITSGKFDWRMAFSTGGMPSSHTSMVIALTTAIGLTSGFGSNAFAISIVFSSIVIYDATGVRRQAGFHAEVLNRLLADFNRLMETMKDPETTNAESRQKLKELLGHKPAEVFFGIITGILTAVLAFIFYPF
>NZ_CP010525.1|WP_035184209.1|1127946_1128729_-|SDR-family-oxidoreductase
MRLKDKVAIVTGGGSGIGEASALKLAAEGAKVCVMDIEQKRADEVKRRIEQNGGEAMALEVDVTDPEQVKTAVDKTVREWDRLDIVFSNAGINGTVAPIEDLSPDDWDQTLTTNLKGTFLLTKYAIPHMKNRGGSIIITSSINGNRIFSNIGMSAYSSSKAGQVAFMKMAALELARYKIRVNAVCPGAIETKIEQNTNRTEALEKVQIPVEFPEGDQPLSEGPGKPEQVADLVLFLASDDSSHISGTDIYIDGTESLLRG
>NZ_CP010525.1|WP_035184211.1|1129085_1130180_+|glycosyltransferase-family-2-protein
MIGNVAVVIPALNPEAQLVHYADRLLAKGAARIIVVDDGSSPACAPIFQMLSQKERCTVLHHPANRGKGRALKTAFAHILAHHGSLSGVVTADCDGQHSPEDVEKMAASLRQHPHSIILGARDFSLEHVPPKSRFGNRLTSFLFKALYGAEIGDTQTGLRGIPKQELGWLLALKGERFEYEMNMLIYARKMNVKIREVPIRTIYFNRNEGTHYRPVKDSLKIFRKIISGLFYYAFPALIFLIADMLSFSLLYRYVLAGIPHVWKVLAATAASQVVAFAAFLMVKYRLLKWKRFLVRYLMACLLFIVVSFLLIEAGSGLLQFDPVLAKTIASLFLALFFYQLQLHWGIFSGYPEYGQLAGERRHG
>NZ_CP010525.1|WP_035184213.1|1130172_1130859_+|glycerol-acyltransferase
MAKGYGLFFKSVRQLVRFVYPSYKAQISGEIAGPAVYVSHHRNLFGPFVILLWYPEFIRTWILHVFLDRKSCSRQYADYTFTKRFGFPRALANPAAFFLSFMITKLLKSGRGIPVFRSSRKIIRTFQESVEALKNGESIAIYPDIDYTDNAAGVKGMYEGFLYLEKYFYKETGRHVQFVPLYASKTKRLLVTGTPVFFREGEDFRTEKEVVYEKLHKALNRLAAQYGE
>NZ_CP010525.1|WP_035184216.1|1131078_1133130_+|methyl-accepting-chemotaxis-protein
MKKQKKFIPLTVKWGGLICAAMLISILATVGLEYATTSHLLKTKNRDVNQMVANEAASQVEAGLAKYETSLDELAGLVGTDLQRKNKMQDIEAKIKSVQTRNKQLVSAYYMDFRTGKLHISPDAKLDLDVRNTNTYRYLQKKPQLQWMDIYKDKVTGAIMTSVVAPVFSGGKMAGAVGYDINLSEMGKIRTNIERDSNNKLAIFDAKGVIVTSFLKNGDGKNAKPANSGKVEGVKDFESSTRLDKDFVFVEKIYRQKTATATFHWNGEGYDVYATTIPKTGWKVASFNPQSEFSAQIGKIKEMGLLSIGIGLLIGIVFAVLISGRLVKIIKNLQQVLAKTAEGDLVTAFAFRSNDEIGELAKSYNAMLHNMRSLIAKVSDSVDNVNKAAAGLRTVTKENEAAVTDVSKAVEEIAAGAANQSDHIETGSNAMRDLGGEIEKLAAQSQVIENAVDQAGTEIQSGTKQVDNLEASYQKLEQAFERVTSMMAGLNEKSKSIAQVADVITQIAEQTNLLSLNASIEAARAGENGKGFAVVANEVRSLAEQSKQSAKDIRATIADVLQDMKELVDVMEETNEISTGQRKAVNSVSTSIAVLAEGLEKMLSSIKQEAASIRSIGEQKDAVVQMIEDLSAVSQQTAAASEEISSSMEEQAASAGELSRYTEKLFTLTEELEREIGEFTIKK
>NZ_CP010525.1|WP_026685163.1|1133402_1134551_+|GntR-family-transcriptional-regulator
MNMSKKYEKIKQDIREKILTEEYKVSEKLPTESELMEMYQVSRFTVRRAIDELEKENFVYRIQGGGIFVDDWKGKPQTVMKNKTIGLITTYISDYIFPNIITGIDNYVSNYGYSILITNTQNNPEKERKSLSNLLSNKISGLIIEPTKSALSNTNKSIYDNIKSLGIPMLFINAVYDDMNIPYLVMDDLKTGEMVTDYLISLGHKKIVGIFKVDDKQGIHRMNGYIKAFQKHPEISNMGEIMMYQTEENKINLFKKLHTILSRPEFAPTAIVCYNDQLAIQVMNFVKEIGLNVPKDLSVIGVDDYQFSKFINPALTTVRHPQEKMGLDAGKMIIDMLNKQPVTSKIYEPELVKRDSVKPLDHSNDNWTEKNREEKAICDNDE
>NZ_CP010525.1|WP_043052483.1|1134745_1136347_-|FGGY-family-carbohydrate-kinase
MNLIETSQAIQQGNVSLGIELGSTRIKAVLVTDDFETIASGGYVWENKFENGIWTYSLEEVWEGIQRSYAQIAADVQGKYHTTLTKISAIGVSAMMHGYLAFAENGELLVPFRTWRNNITEQAADELTERFQFNIPQRWSIAHLYQAILNQEPHVKDIRFITTLAGYVHWKLSGEKVLGIGDASGVFPVDEETGTYREDFLDTFDQLENVAPYPWHISEILPKVLKAGEYAGTLTPEGAALLDVNGNLQAGSLMAPPEGDAGTGMVCTNSVRKRTGNISVGTSAFSMIVLDQPLEKVYRDIDIVTTPSGAPVAMVHINNCSSDINAWANLFKQFAERLGVDLPADRLYETLFLVAAKADPDAGGLLNYSYLSGENITKMPAGRPLFVRKPDSAFTLANFVQAQLYAAFAPLKIGMDILKNEEGIKTDVLIAQGGLFKTPVIGQQVLANALNTPITVMSTAGEGGAWGMAVLAVYAKSGNGKQSLEDFLDQNVFTHPESMTLSPEPEGVSGYEAFIKRYEAGLPVESMAVKSIG
>NZ_CP010525.1|WP_017550147.1|1138050_1139214_-|sugar-ABC-transporter-permease
MDSILQMMKKNMRQYGMFIALVLIMVLFQVITDGILLRPLNITNLVMQNSYVLILAIGMVLIIIAGHIDLSVGSVVAFIGAISAVLSIHMHLPTIVVFVISLAIGACIGAWQGFWVAYVKIPAFIVTLAGMLVFRGLTMLILKGESLAPFPRNFQLVSSGFIPDVFKGSSLNILTIAVGLLCTVAYIFIELNGRKKQKKYQLQTTSGPLFVARIIVIACLINVFSYIFATYEGIPYILVILIALILAYSFVMKRTTMGRQVYAIGGNANAASLSGIKTPRVTFWIFVNMGVLAALTGLIVAARLNAATPKAGTNFELDAIAACFIGGASAYGGIGTVGGAIVGALVMGVMNNGMSILGLGIDWQQTIKGLVLLLAVAFDVYNKNKAV

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Crispr_ID: NZ_CP010525_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_7

1187083-1187183

Orphan

Consensus_repeat	Method
TGGGTTCGATTCCCATCATCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_7

>merge|NZ_CP010525|7|1187083-1187183|CRISPRCasFinder
TGGGTTCGATTCCCATCATCCGCCCTTTGCTGCGGGTGTAGTTTAGTGGTAAAACCACAGCCTTCCAAGCTGTTGTCGTGGGTTCGATTCCCATCACCCGC

>NZ_CP010525|7|8|1187083-1187183|CRISPRCasFinder
TGGGTTCGATTCCCATCATCCGC	CCTTTGCTGCGGGTGTAGTTTAGTGGTAAAACCACAGCCTTCCAAGCTGTTGTCG
TGGGTTCGATTCCCATCACCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_035183985.1\|1195375_1196479_+\|o-succinylbenzoate-synthase	unknown	unknown	gnl\|CDD\|239433
NZ_CP010525.1\|WP_026684902.1\|1192788_1193607_+\|1,4-dihydroxy-2-naphthoyl-CoA-synthase	unknown	unknown	gnl\|CDD\|180958
NZ_CP010525.1\|WP_035183992.1\|1191945_1192749_+\|2-succinyl-6-hydroxy-2,-4-cyclohexadiene-1-carboxylate-synthase	unknown	unknown	gnl\|CDD\|274729
NZ_CP010525.1\|WP_014097641.1\|1196807_1196966_-\|DUF1540-domain-containing-protein	unknown	unknown	gnl\|CDD\|377869
NZ_CP010525.1\|WP_029142729.1\|1178908_1179598_-\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NZ_CP010525.1\|WP_026685171.1\|1164668_1164863_-\|DUF3311-domain-containing-protein	unknown	unknown	gnl\|CDD\|371707
NZ_CP010525.1\|WP_035184000.1\|1188870_1190202_+\|isochorismate-synthase	unknown	unknown	gnl\|CDD\|224091
NZ_CP010525.1\|WP_100183710.1\|1198037_1198166_-\|DUF4021-domain-containing-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_026685172.1\|1163202_1164672_-\|sodium:solute-symporter	unknown	unknown	gnl\|CDD\|223664
NZ_CP010525.1\|WP_026685168.1\|1166851_1167262_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|214628
NZ_CP010525.1\|WP_014097626.1\|1170270_1170477_+\|copper-chaperone-CopZ	unknown	unknown	gnl\|CDD\|188014
NZ_CP010525.1\|WP_014097622.1\|1166328_1166745_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP010525.1\|WP_035184005.1\|1177701_1178769_+\|DUF1646-family-protein	unknown	unknown	gnl\|CDD\|285138
NZ_CP010525.1\|WP_035183989.1\|1193924_1195379_+\|o-succinylbenzoate--CoA-ligase	unknown	unknown	gnl\|CDD\|235146
NZ_CP010525.1\|WP_035184248.1\|1164922_1166110_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|349941
NZ_CP010525.1\|WP_035183982.1\|1197027_1197918_-\|zinc-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238499
NZ_CP010525.1\|WP_035183995.1\|1190203_1191949_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	unknown	unknown	gnl\|CDD\|236020
NZ_CP010525.1\|WP_172653424.1\|1169931_1170255_+\|metal-sensing-transcriptional-repressor	unknown	unknown	gnl\|CDD\|197387
NZ_CP010525.1\|WP_035184255.1\|1170570_1172985_+\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NZ_CP010525.1\|WP_035183998.1\|1187681_1188605_-\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	unknown	unknown	gnl\|CDD\|235695

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_035183985.1\|1195375_1196479_+\|o-succinylbenzoate-synthase	gnl\|CDD\|239433	cd03317, NAAAR, N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building blocks for antibiotics, herbicides, and drugs. NAAAR is a member of the enolase superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	0
NZ_CP010525.1\|WP_026684902.1\|1192788_1193607_+\|1,4-dihydroxy-2-naphthoyl-CoA-synthase	gnl\|CDD\|180958	PRK07396, PRK07396, dihydroxynaphthoic acid synthetase; Validated.	0
NZ_CP010525.1\|WP_035183992.1\|1191945_1192749_+\|2-succinyl-6-hydroxy-2,-4-cyclohexadiene-1-carboxylate-synthase	gnl\|CDD\|274729	TIGR03695, menH_SHCHC, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase. This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	6.09677e-118
NZ_CP010525.1\|WP_014097641.1\|1196807_1196966_-\|DUF1540-domain-containing-protein	gnl\|CDD\|377869	pfam07561, DUF1540, Domain of Unknown Function (DUF1540). This family has four conserved cysteines, which is suggestive of a metal binding function.	8.61231e-10
NZ_CP010525.1\|WP_029142729.1\|1178908_1179598_-\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	5.4375e-50
NZ_CP010525.1\|WP_026685171.1\|1164668_1164863_-\|DUF3311-domain-containing-protein	gnl\|CDD\|371707	pfam11755, DUF3311, Protein of unknown function (DUF3311). This is a family of short bacterial proteins of unknown function.	2.00725e-11
NZ_CP010525.1\|WP_035184000.1\|1188870_1190202_+\|isochorismate-synthase	gnl\|CDD\|224091	COG1169, MenF, Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	7.2336e-137
NZ_CP010525.1\|WP_026685172.1\|1163202_1164672_-\|sodium:solute-symporter	gnl\|CDD\|223664	COG0591, PutP, Na+/proline symporter [Amino acid transport and metabolism / General function prediction only].	2.8229e-75
NZ_CP010525.1\|WP_026685168.1\|1166851_1167262_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|214628	smart00344, HTH_ASNC, helix_turn_helix ASNC type. AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli).	1.6365e-35
NZ_CP010525.1\|WP_014097626.1\|1170270_1170477_+\|copper-chaperone-CopZ	gnl\|CDD\|188014	TIGR00003, COP-associated_protein, copper ion binding protein. This model describes an apparently copper-specific subfamily of the metal-binding domain HMA (pfam00403). Closely related sequences outside this model include mercury resistance proteins and repeated domains of eukaryotic eukaryotic copper transport proteins. Members of this family are strictly prokaryotic. The model identifies both small proteins consisting of just this domain and N-terminal regions of cation (probably copper) transporting ATPases. [Transport and binding proteins, Cations and iron carrying compounds].	4.71185e-19
NZ_CP010525.1\|WP_014097622.1\|1166328_1166745_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	4.0005e-11
NZ_CP010525.1\|WP_035184005.1\|1177701_1178769_+\|DUF1646-family-protein	gnl\|CDD\|285138	pfam07854, DUF1646, Protein of unknown function (DUF1646). Some of the members of this family are hypothetical bacterial and archaeal proteins, but others are annotated as being cation transporters expressed by the archaebacterium Methanosarcina mazei.	1.66633e-103
NZ_CP010525.1\|WP_035183989.1\|1193924_1195379_+\|o-succinylbenzoate--CoA-ligase	gnl\|CDD\|235146	PRK03640, PRK03640, o-succinylbenzoate--CoA ligase.	0
NZ_CP010525.1\|WP_035184248.1\|1164922_1166110_-\|amidohydrolase	gnl\|CDD\|349941	cd08021, M20_Acy1_YhaA-like, M20 Peptidase aminoacylase 1 subfamily, includes Bacillus subtilis YhaA and Staphylococcus aureus amidohydrolase, SACOL0085. Peptidase M20 family, uncharacterized subfamily of bacterial proteins predicted as putative amidohydrolases or hippurate hydrolases. These are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine). This family includes Staphylococcus aureus amidohydrolase, SACOL0085, which contains two manganese ions in the active site, and forms a homotetramer with variations in interdomain orientation which possibly plays a role in the regulation of catalytic activity.	0
NZ_CP010525.1\|WP_035183982.1\|1197027_1197918_-\|zinc-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238499	cd01017, AdcA, Metal binding protein AdcA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AdcA proteins belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. They are comprised of two globular subdomains connected by a long alpha helix and they bind their ligand in the cleft between these domains. In addition, many of these proteins have a low complexity region containing metal binding histidine-rich motif (repetitive HDH sequence).	7.95095e-97
NZ_CP010525.1\|WP_035183995.1\|1190203_1191949_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	gnl\|CDD\|236020	PRK07449, PRK07449, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Validated.	0
NZ_CP010525.1\|WP_172653424.1\|1169931_1170255_+\|metal-sensing-transcriptional-repressor	gnl\|CDD\|197387	cd10152, SaCsoR-like_DUF156, Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156. This domain family includes Staphylococcus aureus CsoR (SaCsoR). SaCsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis; it represses a genetically unlinked copA-copZ operon. copA encodes a copper efflux P-type ATPase, and copZ, a copper chaperone. This family belongs to a larger superfamily that contains various transcriptional regulators that respond to different stressors such as Cu(I), Ni(I), sulfite, and formaldehyde, and includes Mycobacterium tuberculosis CsoR (MtCsoR), Bacillus subtilis CsoR, and Thermus thermophilus CsoR. The latter three proteins do not belong to this family. CsoRs form homotetramers (dimer of dimers). In MtCsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily, including this family, and a conserved Tyr and a Glu residue that facilitate allosteric regulation of DNA binding for CsoRs are also well conserved.	2.19033e-38
NZ_CP010525.1\|WP_035184255.1\|1170570_1172985_+\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP010525.1\|WP_035183998.1\|1187681_1188605_-\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	gnl\|CDD\|235695	PRK06080, PRK06080, 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated.	4.94633e-126

>NZ_CP010525.1|WP_029142729.1|1178908_1179598_-|MgtC/SapB-family-protein
MVFGDLEILYKLGITAVLGLIIGLERELKRKPLGLKTSLVISIISCLLTIVSIQSAYLFNHAHSVQITMDPLRLAAQIVSGIGFLGAGVILKKDNDTITGLTTAAMIWGASGIGIAVGAGFYMEAIAGVVLIIISVEIIPYLMGKAAQTKLRNKDLIIKVIVRNRDAIPCVLDAIEKQQITIENIRIKDLKDQTHLVDLKARASYKHTTVDVYRHISGMDEVAAAEVES
>NZ_CP010525.1|WP_035184005.1|1177701_1178769_+|DUF1646-family-protein
MVMGLSVILLLVLCLPFTKIVERNLEAFLFVMGVAACIVSRSFSWHLVQEALLHPLNITIAVLAMGLLFRWFEKPIEKGISRISHAMPFRLFIALFVIILGLLSSVITAIVAAIVLVAVIRFLRLDRKTEVRLVVLACFAIGLGAVLTPIGEPLSTIVVSKLDADFFYLLRLTGTSVIPAVILFGVLAALIVKPGQYASAMETAAGKEPGIVAKEDEGLKTESASESYKEIVIRSSKIYLFVMALTLLGAGFEPFIEAYLLDLSPLVLYWINMVSAVLDNATLAAAEISPAMGDKAIQDILMGLLISGGMLVPGNIPNIIAAGKLKISSMEYARFAFPLGLAAMVVYFAIILFLV
>NZ_CP010525.1|WP_035184255.1|1170570_1172985_+|copper-translocating-P-type-ATPase
MAASLQEKKDASVTLGITGMTCAACANRIEKNLSKVEGVKKVSVNLATEKAAIQYDTKQATVENLIEKVEKTGYGVLEEKAQLNIIGMTCAACANRVERALKKTPGVVSAAVNLATETASVTYLPGQASAEQMIAAVKKAGYDAKVKGELDPDYEKKMREKAYKKQKIKFAVGAVISVFFLLQMISDIAMHYGGSFSFHMNPWLQLLLATIVQIFVGGHYYRDAYHAIRGGSANMAVLVVLGTSTAYLYSLVLTILGSERMLYFEASAIVMTLIVLGKLMETRAKGQTSEAMKKLIGLQAKTARVNRGGKEIEVPVEEVVSGDILFVRAGEKIPVDGVITEGASSVDESMLTGESMPVSKKAGDAVIGATLNKTGSFRFKATKVGKDTALSQIIKLVEEAQGSKAPIQHLADQISGIFVPIVILIALVTFAVTYFAAGFTPAMVSMVAVLVIACPCALGLATPTAVMVGTGLGAENGVLIKSAEHLQSAHRITTVVLDKTGTITKGEPEVTDLIPYGGFSEDDLLAISAAAEKGSEHPLGAAIVKKAAEKGLQLPNVMEFEAVPGRGIRVKIEEREVLIGNKKMMEDAHIRIDDVISQMEKLEEDGKTAMLVAMDGALSGLIAVADTVKETSAKAIRMLKEMGIETVMMTGDNRRTAEAIARQVGVDRVLAEVLPEDKSKEIEKLKRAGNITAMVGDGINDAPALAAADVGIAIGTGTDVAMEAADITLMRGDLMGIVNTIRLSKATMRKIRQNLFWAFAYNVVLIPVAAFGLLNPILAGAAMAFSSVSVVGNTLFLRKWQPVS
>NZ_CP010525.1|WP_014097626.1|1170270_1170477_+|copper-chaperone-CopZ
MEKVTLNVQGMSCEHCVKAVKGSVGELSGVKNVDVHLAEGKVDVEFDPNKVTLDKVKEAIEDQGYEVA
>NZ_CP010525.1|WP_172653424.1|1169931_1170255_+|metal-sensing-transcriptional-repressor
MDARNEASVCPAHSERKSHHSEKVKRNLVSRLNRIEGQVRGVKGLIEKDTYCDDVITQIAAIQSALNGVSKILLEGHLKNCVLERIQEGDLDVLDEFLVTIQKTMRK
>NZ_CP010525.1|WP_026685168.1|1166851_1167262_+|Lrp/AsnC-family-transcriptional-regulator
MDFIDEQIIHELKEDSRLSMSELSRRIHLSAPAVRERVRQLEEQDIIKRYTIELNQKKLGYPIEAIIEATIKNNRYDDFKKQICQYSNVDFCYRIAGEACFMLKARFHSFEDAEQFIDELQLFAHSKTNFIFSKVI
>NZ_CP010525.1|WP_014097622.1|1166328_1166745_-|carboxymuconolactone-decarboxylase-family-protein
MTLIPLHERGNTPFQQLLGYNASILKYWNKLSDEFEKDGRLSAKLKEEVRRTLAQKNGCLYCKAKGKPNPVDYDEKTAVCTGFAEAFLAGKGQTSPNVTAVLKEYLTDAEISELIAFICFTTASQYFGALMQLGEQQR
>NZ_CP010525.1|WP_035184248.1|1164922_1166110_-|amidohydrolase
MALSLEAEKIDALVEQVKEDVIHWRRHLHQNPELSFKEVETSQFIYDTLASFGGLVLSRPTKTSVVARLKGAKPGRVLAIRADMDALPIQEENAFDFVSKHDGVMHACGHDGHTAMLLGAAKILAGLKDQIAGEIRFLFQHAEEQLPGGAEEMVQAGVMDGVDQVIGAHLWSPLEAGKIELVSGPMMAAPDAFYITINGKGGHGAQPHLAIDSIAIGAQVVTNLQHIVSRNIDPLDPVVLSVTQFIAGTAHNVIPGSVFISGTVRTFKPALQEEVIRLMERVVKGVTEAHGAAYDFQYVKGYRPVINDPEVTAKLREVLVEAFGEDAIQDGVPTMGGEDFSGFQQKAPGTFFFIGAGNADKGIVYPHHHARFTVDEDVLPYGVKAFVAASLTLTA
>NZ_CP010525.1|WP_026685171.1|1164668_1164863_-|DUF3311-domain-containing-protein
MKFVLASLPFLALIIGMFFANRTDPMILGMPFIMFWTVLWVVLSTVVMFIIYKTDPKNQRGDAE
>NZ_CP010525.1|WP_026685172.1|1163202_1164672_-|sodium:solute-symporter
MNSALLVILVFLLVSLYLGIRARRGKQMNLEQWATGGRSFGTLFVFLLSAGEIYTTFTFLGGSGWAYGKGGPTLYILWYGSLAYVLSYWLLPAIWRYAKEHKLLSQSDFFAKKYNSPALGVLVSIIGIVAMIPYLVLQLKGLGSIVSIASYGSISSGVAIWIGVIAVTIYTTISGVHGTAWTSVMKDALVLAVVVFLGIYLPVHYFGGFSDMFHAIDQAKPGFLALPHQGMSVYWFISTVLLTALGFYTWPHSFAASFTAKNEKTFRRNAVIFPLYQLILLFVFFAGFAAILTVKPALEGAATDNALLVLSIESFPHWFVGVIGAAGLLCALVPGSLLLMSASTMISKNLFKVFKPDANETQVANVAKYLVPVVSLIALYFTFNGGQTIVALLLMGYSMVTQFFPAIVFSFMKNNPISKAGAFAGIVAGELVVSYVTITNQTVATLLPFMPQAVKDLNTGIIAMVLNLIVTFAVSAFTRDRQKSVEMAA
>NZ_CP010525.1|WP_035183998.1|1187681_1188605_-|1,4-dihydroxy-2-naphthoate-polyprenyltransferase
MNAQSSPAIGPDKGWRIWWQLTRPHTLTAGFVPVILGTVLALGIARINLLLFAAMLVATLLIQAATNMFNEYYDYKRGLDTEHSVGIGGAIVRNGIKPKTVLHLAFAFFGAAMLIGVYICSQSSWWIAVIGTVCMLVAYLYTAGPFPISSTPLGELISGFFMGVIIILISFFIQTKTITWPIVFISIPIMILIGAIMLSNNIRDLDGDKANGRKTIAILLGRKGAILLLAAMFALSYLWMAGLVLFGVVTPWVLLVFVSTPKPVRAIKGFIGKSEPLQMLPAMKATAQTNTIFGVLLSISFLIDHFI
>NZ_CP010525.1|WP_035184000.1|1188870_1190202_+|isochorismate-synthase
MKEKTAPALKLVSKVIKCRTAPDPLRLFTAGAAHFYGSRFFWQDADRETVFVGFGCVWSCTVTASDGFAQMEDEWRNLKGAGEVYSGTGETGTGPVLFGGFAFDGTVAKQKWKTFGQGIFRVPQILFTFKKDAVFLTVNGCGGTESVQEAEETVRSLLNGSTAFPALPLLKAVKEIGSDEWKKSVATAVEFIREGRMDKVVLARKLELAFDGVVSPDAVLAALSVQQHDSYLFVLEEGSESFIGASPERLVKKTGRHILSTCLAGSIKRGRNEAEDLELGKALLSDQKNLSEHGFVVSMIRQVLEPFCNGLNVPDEPVLMRMRDIQHLYTPVTGTVKDKDTTLFQLVKALHPTPALGGIPRQPAMEAIRLLEKMDRGLYGAPIGWVDYRGSGEFCVGIRSGLLKEDRASLYAGCGVVKESEPEEEYKETSVKFTPMLRALGGK
>NZ_CP010525.1|WP_035183995.1|1190203_1191949_+|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase
MEHQEIMTTYLAAFIRQLSAMGIRYAVVSPGSRSTPIAMLLAEHPDFQIYMDIDERSAAFFALGLAKEKRKPVVLLCTSGTAAANYYPAVAEANISRVPLIVLTADRPHELRNVGAPQAIDQIRLYGTHVKWFEEMPLPEAEEEVLQFVRQTAARAVVTALQQPAGPVHLNFPLREPLVPVLKPSPFAGEVPVPAIENFSGTLRLSEETVEIVAKEIREKDRGLIICGPIDIPGFAEAVVALSEKTGYPVLADPLSQLRSGRHGKERIIENYDSLLKDPKWAGRLAPNVVIRFGAMPVSKPLTLLLKKVKTAAHYIVDGGNGWRDPVKRGTTVVYSDEIDFCKKLSNIIVMNPVSEWFTMWEKLNQQARQIVTASLEVEKTFDEGKTVTELAAALPDGSTLFVGNSMPIRDVDTFFQATDKKIRILANRGANGIDGVVSSATGVSAGCGKAFLLIGDLSFFHDLNGLLMTKMHKLNLCVILINNNGGGIFSFLPQADEPEKFEQLFGTPTDLAFEYAVKMYGGSYIQPQNWDQFRAALSEYKGGLQVIEVRTNRAKNVETHRKIWSQVSREMERYFQGEQQ
>NZ_CP010525.1|WP_035183992.1|1191945_1192749_+|2-succinyl-6-hydroxy-2,-4-cyclohexadiene-1-carboxylate-synthase
MRINGLEYHVETAGDGEPLLLLHGFTGNGNTWNDTVSILRDEFRCIVVDIIGHGKTEKPDDPGRYDITKAAADLRAVLLALGIRRASVLGYSMGGRLALTFAVQYPQMVDKLVLESASPGLKTEAERLARRERDEQLAERILTGCMEAFVSHWENLPLFASQKQLPAEVREKIRKQRLENDPAGLANSLRGMGTGAQPSWWGRLSELHFPVLLAAGEWDAKFCRIAGEMEEQLPHAKKIIFSHAGHAIHVEDPKKFGTMIKGFLKNC
>NZ_CP010525.1|WP_026684902.1|1192788_1193607_+|1,4-dihydroxy-2-naphthoyl-CoA-synthase
MAVEWKTEHEYEDILYESYNGIAKITINRPHVRNAFRPETVTEMYDAFSRARDDANIGVIILTGMGEKAFCSGGDQKVRGNGGYVGSDNIPRLNVLDLQHLIRVIPKPVIAMVAGYAIGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDGGYGAGYLARIVGHKKAREIWYLCRQYNAQEALEMGLVNAVVPYEKLEEETIKWAEEILEKSPMAIRFLKAAFNADTDGLAGLQQFAGDATLLYYTTDEAKEGRDAFKEKRKPDFGQFPRFP
>NZ_CP010525.1|WP_035183989.1|1193924_1195379_+|o-succinylbenzoate--CoA-ligase
MLPNFLKQRAYLTPNRIALISQGTSLTFAGLYEKAKETARKLSSCGLQAEDTAAVLLNSRAETVIILHALQQLRVRTLFLNHRLTPAEMQYQLTDSGAKWLITEKSFREKAEVLNETATVIQSEALDDLPAAGYEERAEFAFEDVCSIMYTSGTTGKPKGVLQTYGNHWWSAAGSALNLGVREDDTWLCAVPLFHISGFSILMRSVFYGMTVYLMEKFDEKETAKLLKSGRITTMSVVTNMLQRLLRELGQERLHPNFRCLLLGGGPAPRPLLEACAEKNIPVFQSYGMTETASQTVTLAPEDSLRKIGSAGKPLFPAQIRIVSDGKVCGPFEHGEIAVKGPNVTIGYLNRPDANQKSFRDGWFFTGDIGYLDDEGFLYVLDRRSDLIISGGENIYPAEIEEVLLAHPDILEAGVIGVEDEKWGQVPAAFIVTKRAVQERELQAFCETRLAKFKIPKKVYAVPALPRNASNKLVRRKLLELLPS
>NZ_CP010525.1|WP_035183985.1|1195375_1196479_+|o-succinylbenzoate-synthase
MIGIEKVTLSVIKMPLKSPFENALEKVTEREAILLEVTDNDGVTGFGEAVAFSTPWYTEETVQTCFHMLKDVLVPLLREKPVAHPKEVSGRFQSVRRNHMAKAAIETAIWDLYAKKKQKPLWQLIGGARDHVDAGVAVGSHDTAEALRQIAAFVDEGYKRVKVKIKPGHDEAFIREIRHAFPDLALMADANSAYTLADAPRLKRLDRYGLLMIEQPLAADDIVEHAALQKQLETPVCLDESIVTYHDAESALRLGSFRVLNIKIGRVGGLYPAIRLHDLCASRGIPVWCGGMIEFGVSRAFNLALASLPGFTIPGDISSSSRFWEKDIIEPEITVENGQIRLPDRPGTGFEIDRAYVEKIRTYTETI
>NZ_CP010525.1|WP_014097641.1|1196807_1196966_-|DUF1540-domain-containing-protein
MAKDVLCEVRNCVFWEEGNLCSAEEIYIVSHTGTQAENQRETDCKTFESMFS
>NZ_CP010525.1|WP_035183982.1|1197027_1197918_-|zinc-ABC-transporter-substrate-binding-protein
MKKLFPVLLAFTMLFVTACANKQESKQDHKISVYTTVYPLEYVTQQIGGKYVSVKTIYPPGTDEHTYEPSQKDILKLADSDFFFYIGLGLEGFANKAKQVLEGQNVKMMALGDRLPVPDKTSAKADPHVWLDPIYVKQMAGMITTQLSKKMPKQKTYFKKNYDQLAKKLDRVNAAYKQAVEKSDNKELVVSHAAYGYWVKRYGIKQIPIAGLSTSDEPSQKQLENIIQKVKQDHISYIVFEKNVPSKIAEVVQQETNTKAVYIHHLGVRTNAEIKAHKDYFTLMDDNLKALEKALQ
>NZ_CP010525.1|WP_100183710.1|1198037_1198166_-|DUF4021-domain-containing-protein
MFFMEEKKEQQKKSGDFGADPDEQAINGDYGMLETEEEDKKD

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP010525_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_8

1792496-1792583

Orphan

Consensus_repeat	Method
TGAACAGTCCATCTGTTCAAAATG	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP010525_8

>merge|NZ_CP010525|8|1792496-1792583|CRISPRCasFinder
TGAACAGTCCATCTGTTCAAAATGAGCAGTCGACTGTTCAAAATGAACAGACGATTGTCCAAAATGAGCAGTCCATCTGTTCAAAATG

>NZ_CP010525|8|9|1792496-1792583|CRISPRCasFinder
TGAACAGTCCATCTGTTCAAAATG	AGCAGTCGACTGTTCAAAATGAACAGACGATTGTCCAAAA
TGAGCAGTCCATCTGTTCAAAATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_035184739.1\|1790793_1791063_+\|group-specific-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035184744.1\|1793722_1793932_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375149
NZ_CP010525.1\|WP_052042163.1\|1787128_1788091_-\|3'-5'-exoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235864
NZ_CP010525.1\|WP_035184729.1\|1788120_1789038_-\|NAD-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|349379
NZ_CP010525.1\|WP_035184742.1\|1791798_1792164_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035184750.1\|1794718_1795021_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035184727.1\|1785082_1787083_-\|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl\|CDD\|223989
NZ_CP010525.1\|WP_035184757.1\|1795546_1796233_+\|phage-antirepressor-KilAC-domain-containing-protein	unknown	unknown	gnl\|CDD\|226144
NZ_CP010525.1\|WP_035184741.1\|1791443_1791635_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_080738177.1\|1793135_1793528_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|180915
NZ_CP010525.1\|WP_035184746.1\|1794064_1794253_+\|BH0509-family-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035184732.1\|1789731_1789959_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376540
NZ_CP010525.1\|WP_035184760.1\|1796335_1796791_+\|ArpU-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|273725
NZ_CP010525.1\|WP_035184753.1\|1795026_1795227_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035184762.1\|1796787_1797330_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271192
NZ_CP010525.1\|WP_035184735.1\|1790247_1790769_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP010525.1\|WP_043052499.1\|1791075_1791357_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340163
NZ_CP010525.1\|WP_035184748.1\|1794521_1794704_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035184755.1\|1795244_1795484_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035184731.1\|1789166_1789586_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_035184744.1\|1793722_1793932_+\|hypothetical-protein	gnl\|CDD\|375149	pfam17356, PBSX_XtrA, Phage-like element PBSX protein XtrA. This is a family of unknown function found in Bacilli.	1.54291e-09
NZ_CP010525.1\|WP_052042163.1\|1787128_1788091_-\|3'-5'-exoribonuclease	gnl\|CDD\|235864	PRK06807, PRK06807, 3'-5' exonuclease.	5.98732e-65
NZ_CP010525.1\|WP_035184729.1\|1788120_1789038_-\|NAD-dependent-DNA-ligase	gnl\|CDD\|349379	cd17748, BRCT_DNA_ligase_like, BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins. LigA, also called NAD(+)-dependent polydeoxyribonucleotide synthase, catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.	4.74134e-20
NZ_CP010525.1\|WP_035184760.1\|1796335_1796791_+\|ArpU-family-transcriptional-regulator	gnl\|CDD\|273725	TIGR01637, Putative_autolysin_regulatory_protein_ArpU, phage transcriptional regulator, ArpU family. This model represents a family of phage proteins, including ArpU, called a putative autolysin regulatory protein. ArpU was described as a regulator of cellular muramidase-2 of Enterococcus hirae but appears to have been cloned from a prophage. This family appears related to the RinA family of bacteriophage transcriptional activators and to some sporulation-specific sigma factors. We propose that this is a phage transcriptional activator family. [Mobile and extrachromosomal element functions, Prophage functions, Regulatory functions, DNA interactions].	2.00141e-32
NZ_CP010525.1\|WP_035184727.1\|1785082_1787083_-\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	9.39098e-35
NZ_CP010525.1\|WP_035184757.1\|1795546_1796233_+\|phage-antirepressor-KilAC-domain-containing-protein	gnl\|CDD\|226144	COG3617, COG3617, Prophage antirepressor [Transcription].	1.40157e-34
NZ_CP010525.1\|WP_080738177.1\|1793135_1793528_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|180915	PRK07275, PRK07275, single-stranded DNA-binding protein; Provisional.	1.37004e-48
NZ_CP010525.1\|WP_035184732.1\|1789731_1789959_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	3.65786e-12
NZ_CP010525.1\|WP_035184762.1\|1796787_1797330_+\|site-specific-integrase	gnl\|CDD\|271192	cd01192, INT_C_like_3, Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain. Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.31868e-57
NZ_CP010525.1\|WP_035184735.1\|1790247_1790769_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.01426e-05
NZ_CP010525.1\|WP_043052499.1\|1791075_1791357_+\|hypothetical-protein	gnl\|CDD\|340163	pfam17448, yqaH, Uncharacterized protein YqaH. This is a family of unknown function found in Bacillus.	2.48526e-05
NZ_CP010525.1\|WP_035184731.1\|1789166_1789586_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	8.35315e-19

>NZ_CP010525.1|WP_035184742.1|1791798_1792164_+|hypothetical-protein
MTLTRKEKREIRLEICRNMDLYCKSCPIRGNKKINHNTIYCRKNCLVGALLQELAFKLIEDEKQLDHSLAKTGTWTEEEDFYLIHHASLYDDEHLAMRLNRTPVSVHRRMIHLNLLEKVRN
>NZ_CP010525.1|WP_035184741.1|1791443_1791635_+|hypothetical-protein
MNETDFDTLWADFLDVPIDLEHQIAVFPFFLGRIKALLKNKETISKEELCDALKKSIQHATSI
>NZ_CP010525.1|WP_043052499.1|1791075_1791357_+|hypothetical-protein
MLKVDQFLRQDLAKAIVEYKCAFELSKEATALLIRENDFEKSIQYTEDLLKSLKALQKMKEKREMLERIHKVAVELQQQNVDIKTIVLKKAGI
>NZ_CP010525.1|WP_035184739.1|1790793_1791063_+|group-specific-protein
MLKVEIDEQEVRNLYLERIEEKLKQVDAELVFWDSAELKRRTGMSWNTILKEFFYDERFPKYKVGRDWRFPAEETKQFLLTWLKEQPRH
>NZ_CP010525.1|WP_035184735.1|1790247_1790769_+|helix-turn-helix-transcriptional-regulator
MKLGKEMANARKRKGITQESLASNTPVSRESIAKYETGARTFPDDLRSVMANELDDVEFYFLAWCDAAGKVSIPYFNGENIDHHPTSMAFLVQAETNEALDKLQDIPWAKPVHTRTAQELEETKKLIFELLDAAASMVNLVGVICNEHQFSMKQLFTQWRLSLRSRNYIDKDF
>NZ_CP010525.1|WP_035184732.1|1789731_1789959_+|helix-turn-helix-transcriptional-regulator
MEKKLLVQRRELLGYSQQDVADLVGIDRSYYTKIENGLTPSVKVAKALGYHLGFDWTFFFDDDCVKNTQKSKEVS
>NZ_CP010525.1|WP_035184731.1|1789166_1789586_-|helix-turn-helix-transcriptional-regulator
MGYGDRLKRLRDKRNLSQQQLADALNINRSTYARYELGQTQPDFETLEKIASFFDVSIDYLIKGEDTTNNSVKSNLPEHKNDSLAEINKLIKEYGIEQIGFFDIDKWKNLSKDDIDEIRRHFEWVAQKAKERNDEKPSD
>NZ_CP010525.1|WP_035184729.1|1788120_1789038_-|NAD-dependent-DNA-ligase
MGKQYSEVNEYRMYTTKAELHKAVNSLMGLIRGIQYDGIITNEELAEVFHWCNLHRHLENKSPFNEIIPMIDSVLDDGQLDEEEIQDIQWLCNRILHQDEFDEFYDLVTVSIQELEGILHGMLADRKLDDTEIDQLEEWMENHSFLLKGTYPFDEIDSLLTAVKHDGVVTKEEKSMLTAFFANFIDTKLSHNIHEPEIRSLQEKFSINGICAVCPEITFENKIFSFTGTSARATRNEIAEVINNKGGIFNNNVNKKTNYLIVGADGNPCWAYSCYGRKVEKAVQLRKAGSPIVIVHENDFWDETY
>NZ_CP010525.1|WP_052042163.1|1787128_1788091_-|3'-5'-exoribonuclease
MNIYKEKWYHSPWLICLLAVLWKASVFFLFISIILLITRSVSIKRFKKHMQQSKPATHEPDPIKGEIQQLKLKKENVVRDTIKLQQEKDALEKQISMLNTEITALKKEIESAKTENKKPVENIVPAPAKRNMTKVSKADYFKYTKARVYPDNYTVIDFETTGLKPENSKIIQIGAVKFQNHQKIDEFVTLINPDVPIPTNITRITGITNDDLIGAPSIKEKLPELLSFIGSDTLVAHNAPFDMKFLLHNMYAENLPYQKFRVVDTLTLARRHIKNTDNHKLETLKQYLGLDTFSSHEALSDCLVTGELYQHCLEMQRAYV
>NZ_CP010525.1|WP_035184727.1|1785082_1787083_-|DEAD/DEAH-box-helicase-family-protein
MNKFQSTQANIHNNNSLYEAQKQAYKAAFAHYQEFPDFKFRETLIVMPTGTGKTGVMAILPYGISKGRVLIITPGKIVRKTVYEQFDSAQNPERTFWIKRNVIYDRKALPNSYLYKGYNPKIDGEKELTMKKLTMSDIVITNVHKLGSSNDEVNLMSLVKKDFFDMIIVDEAHHVAANMWKEALEYFSASKVIKLTATPFRSDNQSISTNEYDPIYEYTLGEAINDGLIKNIVKQEEIPGEIILKNQVTGQIYSLEKAKEILGNDFVSKQIAMDEHCSKQVIERTKDILLKKRKSYPNHQVLAVTCNDEHAKDICKWFNDYDLKATYVSTKSLSENEIEKRLNDFANGVYDVMVSIQMLGEGYDNPNISIISLFRPFKTISPYAQAIGRGLRRIYAENLNPIDNYCNVVYHQELGLEQLWKYYKEQETYGEKIKLQRKKLFEQLSFNFDELGFVERRPSPNASNTRNESDDDFFNSIQKILSVSSMTSRGLGKEDSFTQDGMKNYKQQLEALLQQEKQELDDYKQSVFERVRKGELDQFEADLLIKTKEEATQHSVNTNYSDFRDFIISDSLREDFTNWLNIKLEEFFNSSILNKEGFELFKDDPSVDKQEVNNIGYISRNIRQSLYSASKKHVSAYNQTDFAIAKQRVVDKLSFWLKQYGQNKEE
>NZ_CP010525.1|WP_080738177.1|1793135_1793528_+|single-stranded-DNA-binding-protein
MINRVVLTGRLTADPVLRYTPSGVAVTTFTLAVNRTFSVQSGKKEADFVSVIAWRKIAENIANYLSKGNLIGVDGRLQTRSYEDNNGKRVFVTEVVSEHVCFLETKKNRLANEPQGSQDLPPFSDDNLPF
>NZ_CP010525.1|WP_035184744.1|1793722_1793932_+|hypothetical-protein
MAEKRIGEIELLEDLTIKQAIEPDKVIIVVLDGKRGIARKCEAVEHGSTIIETVNGKSKKITFIESYLT
>NZ_CP010525.1|WP_035184746.1|1794064_1794253_+|BH0509-family-protein
MLRKKPVDRKILSQKERLLLIEWLYVITGFTRSFWKEKSDAEIIRLYESNLEMNQMEDEFVR
>NZ_CP010525.1|WP_035184748.1|1794521_1794704_+|hypothetical-protein
MNELENSINFLKEQLIAAGEKWKGGMDVEPMRDCLAIVEAINVLEERAFGRMITTIAYIL
>NZ_CP010525.1|WP_035184750.1|1794718_1795021_+|hypothetical-protein
MQNVLEFEELMINILDEPSKFKFHFSENGIKISAWIKEAVNLGNGLCIAFDGGSLLVWKDNRVVKCRRPSDLITYCELCFSVFNEFDENIGYLYVPARKR
>NZ_CP010525.1|WP_035184753.1|1795026_1795227_+|hypothetical-protein
MRHQSQRIPTHDYLGRKVWIGEKATLFSSNGVHYEGTIQQIGGKRWFVVNESMRIGGIGSLYLMKD
>NZ_CP010525.1|WP_035184755.1|1795244_1795484_+|hypothetical-protein
MSESFRLYKVVETDGQSAEELQKVLNAATDGFTEMQIDHVVGTKIILGYDSPLNAKGRAEMSVKKAIGSQAKSSFRPIY
>NZ_CP010525.1|WP_035184757.1|1795546_1796233_+|phage-antirepressor-KilAC-domain-containing-protein
MNQIQQVFGYGMSQLRTVLIDSDVWFVAKDVCDILEVRNTTQAIARLEDDERTMLNIGRQGATNLVNEPGLYSLIMSSRKPEARAFKRWITHDVIPQIRKTGSYSTQVPQTFSEALRLAADLQEEIEKAKPKIESFDRFISGKNYQKMGDVAKILGYGRNNFFKLLREMKILMRDNTPYQEFINRGYFVVKEKPIQMGSHVINKPQTYVTAKGIHYIDKLLKERSIIV
>NZ_CP010525.1|WP_035184760.1|1796335_1796791_+|ArpU-family-transcriptional-regulator
MMEQLSFQLAEIDREETRKRVEGALEKYRVLLLTQELDQVPKVTSSYSLVPPSNTNQFHSSTEEAAVKNVDYERERSDYIRKVSMSVNRLGFKERAILIRRYMTEDDVFDYEVYNELNMSERTYHRIKSRAFYKLAFALKVEVYKEKEMSV
>NZ_CP010525.1|WP_035184762.1|1796787_1797330_+|site-specific-integrase
MNVVQPIRDPVKIEKMKNYLKSKSERNYILFMLGISVGLRISDILKLKKEDILRSHIDIKETKTKKNKRVKIPGYIKKEIIPYAKTLADGDYLIKSRQGANRPIDRSTAYRILRDAAKHVGLTDIGTHTLRKTFGYHFYMQTKNVALLQELLNHSRPDITLRYIGINQDTLDKAMDKFRI

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP010525_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_9

2433316-2433391

Orphan

Consensus_repeat	Method
TAGACGACCTCTACGTGAAGAAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_9

>merge|NZ_CP010525|9|2433316-2433391|CRISPRCasFinder
TAGACGACCTCTACGTGAAGAAAGACCGTCGTTTTTCCATGCTTCCTTAACATAGACGCCCTCTACGTGAAGAAAG

>NZ_CP010525|9|10|2433316-2433391|CRISPRCasFinder
TAGACGACCTCTACGTGAAGAAAG	ACCGTCGTTTTTCCATGCTTCCTTAACA
TAGACGCCCTCTACGTGAAGAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_014095657.1\|2437438_2438857_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340924
NZ_CP010525.1\|WP_014095643.1\|2421604_2422075_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035181974.1\|2433491_2434253_+\|fumarylacetoacetate-hydrolase	unknown	unknown	gnl\|CDD\|226480
NZ_CP010525.1\|WP_014095656.1\|2435183_2436107_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235853
NZ_CP010525.1\|WP_017552138.1\|2430074_2430827_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_CP010525.1\|WP_026683812.1\|2432467_2432902_+\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|236820
NZ_CP010525.1\|WP_035181970.1\|2424088_2425657_-\|peptide-chain-release-factor-3	unknown	unknown	gnl\|CDD\|179105
NZ_CP010525.1\|WP_035181980.1\|2441712_2441895_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035181975.1\|2434474_2434750_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_026683813.1\|2431081_2432293_-\|NO-inducible-flavohemoprotein	unknown	unknown	gnl\|CDD\|237337
NZ_CP010525.1\|WP_017552144.1\|2425873_2426950_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|236901
NZ_CP010525.1\|WP_080666392.1\|2428745_2429192_+\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|153102
NZ_CP010525.1\|WP_172653431.1\|2448500_2449829_-\|SLC45-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340871
NZ_CP010525.1\|WP_035181982.1\|2445280_2445970_-\|beta-phosphoglucomutase	unknown	unknown	gnl\|CDD\|213672
NZ_CP010525.1\|WP_035181978.1\|2439515_2440505_-\|lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|240661
NZ_CP010525.1\|WP_014095642.1\|2420476_2421280_-\|TerC-family-protein	unknown	unknown	gnl\|CDD\|274742
NZ_CP010525.1\|WP_014095646.1\|2427204_2428191_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP010525.1\|WP_035181979.1\|2441168_2441462_-\|TIGR04197-family-type-VII-secretion-effector	unknown	unknown	gnl\|CDD\|275045
NZ_CP010525.1\|WP_035181983.1\|2446198_2448475_-\|glycoside-hydrolase-family-65-protein	unknown	unknown	gnl\|CDD\|237517
NZ_CP010525.1\|WP_043052469.1\|2422237_2423647_-\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_014095657.1\|2437438_2438857_-\|MFS-transporter	gnl\|CDD\|340924	cd17366, MFS_ProP, Proline/betaine transporter of the Major Facilitator Superfamily of transporters. This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.8387e-178
NZ_CP010525.1\|WP_172653431.1\|2448500_2449829_-\|SLC45-family-MFS-transporter	gnl\|CDD\|340871	cd17313, MFS_SLC45_SUC, Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters. This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.77054e-102
NZ_CP010525.1\|WP_035181974.1\|2433491_2434253_+\|fumarylacetoacetate-hydrolase	gnl\|CDD\|226480	COG3971, COG3971, 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism].	5.41388e-30
NZ_CP010525.1\|WP_017552138.1\|2430074_2430827_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	4.77215e-20
NZ_CP010525.1\|WP_014095656.1\|2435183_2436107_+\|SDR-family-oxidoreductase	gnl\|CDD\|235853	PRK06701, PRK06701, short chain dehydrogenase; Provisional.	6.05557e-173
NZ_CP010525.1\|WP_026683812.1\|2432467_2432902_+\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|236820	PRK11014, PRK11014, HTH-type transcriptional repressor NsrR.	5.69376e-48
NZ_CP010525.1\|WP_035181970.1\|2424088_2425657_-\|peptide-chain-release-factor-3	gnl\|CDD\|179105	PRK00741, prfC, peptide chain release factor 3; Provisional.	0
NZ_CP010525.1\|WP_026683813.1\|2431081_2432293_-\|NO-inducible-flavohemoprotein	gnl\|CDD\|237337	PRK13289, PRK13289, NO-inducible flavohemoprotein.	0
NZ_CP010525.1\|WP_017552144.1\|2425873_2426950_-\|PAS-domain-containing-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	1.36857e-71
NZ_CP010525.1\|WP_080666392.1\|2428745_2429192_+\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|153102	cd01043, DPS, DPS protein, ferritin-like diiron-binding domain. DPS (DNA Protecting protein under Starved conditions) domain is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. Some DPS proteins nonspecifically bind DNA, protecting it from cleavage caused by reactive oxygen species such as the hydroxyl radicals produced during oxidation of Fe(II) by hydrogen peroxide. These proteins assemble into dodecameric structures, some form DPS-DNA co-crystalline complexes, and possess iron and H2O2 detoxification capabilities. Expression of DPS is induced by oxidative or nutritional stress, including metal ion starvation. Members of the DPS family are homopolymers formed by 12 four-helix bundle subunits that assemble with 23 symmetry into a hollow shell. The DPS ferroxidase site is unusual in that it is not located in a four-helix bundle as in ferritin, but is shared by 2-fold symmetry-related subunits providing the iron ligands. Many DPS sequences (e.g., E. coli) display an N-terminal extension of variable length that contains two or three positively charged lysine residues that extends into the solvent and is thought to play an important role in the stabilization of the complex with DNA. DPS Listeria Flp, Bacillus anthracis Dlp-1 and Dlp-2, and Helicobacter pylori HP-NAP which lack the N-terminal extension, do not bind DNA. DPS proteins from Helicobacter pylori, Treponema pallidum, and Borrelia burgdorferi are highly immunogenic.	5.14977e-61
NZ_CP010525.1\|WP_035181982.1\|2445280_2445970_-\|beta-phosphoglucomutase	gnl\|CDD\|213672	TIGR01990, bPGM, beta-phosphoglucomutase. This model represents the beta-phosphoglucomutase enzyme which catalyzes the interconverison of beta-D-glucose-1-phosphate and beta-D-glucose-6-phosphate. The 6-phosphate is capable of non-enzymatic anomerization (alpha <-> beta) while the 1-phosphate is not. A separate enzyme is responsible for the isomerization of the alpha anomers. Beta-D-glucose-1-phosphate results from the phosphorylysis of maltose (2.4.1.8), trehalose (2.4.1.64) or trehalose-6-phosphate (2.4.1.216). Alternatively, these reactions can be run in the synthetic direction to create the disaccharides. All sequenced genomes which contain a member of this family also appear to contain at least one putative maltose or trehalose phosphorylase. Three species, Lactococcus, Enterococcus and Neisseria appear to contain a pair of paralogous beta-PGM's. Beta-phosphoglucomutase is a member of the haloacid dehalogenase superfamily of hydrolase enzymes. These enzymes are characterized by a series of three catalytic motifs positioned within an alpha-beta (Rossman) fold. beta-PGM contains an inserted alpha helical domain in between the first and second conserved motifs and thus is a member of subfamily IA of the superfamily. The third catalytic motif comes in three variants, the third of which, containing a conserved DD or ED, is the only one found here as well as in several other related enzymes (TIGR01509). The enzyme from L. lactis has been extensively characterized including a remarkable crystal structure which traps the pentacoordinate transition state. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	2.30146e-83
NZ_CP010525.1\|WP_035181978.1\|2439515_2440505_-\|lactate-dehydrogenase	gnl\|CDD\|240661	cd12185, HGDH_LDH_like, Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains. This group contains various putative dehydrogenases related to D-lactate dehydrogenase (LDH), (R)-2-hydroxyglutarate dehydrogenase (HGDH), and related enzymes, members of the 2-hydroxyacid dehydrogenases family. LDH catalyzes the interconversion of pyruvate and lactate, and HGDH catalyzes the NAD-dependent reduction of 2-oxoglutarate to (R)-2-hydroxyglutarate. Despite often low sequence identity within this 2-hydroxyacid dehydrogenase family, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain.	2.4888e-179
NZ_CP010525.1\|WP_014095642.1\|2420476_2421280_-\|TerC-family-protein	gnl\|CDD\|274742	TIGR03716, R_switched_YkoY, integral membrane protein, YkoY family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains proteins YceF and YkoY from Bacillus subtilis. A transport function is proposed.	1.00503e-98
NZ_CP010525.1\|WP_014095646.1\|2427204_2428191_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.63977e-62
NZ_CP010525.1\|WP_035181979.1\|2441168_2441462_-\|TIGR04197-family-type-VII-secretion-effector	gnl\|CDD\|275045	TIGR04197, conserved_hypothetical_protein, type VII secretion effector, SACOL2603 family. Members of this protein family are similar in length and sequence (although remotely) to the WXG100 family of type VII secretion system (T7SS) targets, described by family TIGR03930. Phylogenetic profiling shows that members of this family are similarly restricted to species with T7SS, marking this family as a related set of T7SS effectors. Members include SACOL2603 from Staphylococcus aureus subsp. aureus COL. Oddly, members of family pfam10824 (DUF2580), which appears also to be related, seem not to be tied to T7SS.	2.14367e-12
NZ_CP010525.1\|WP_035181983.1\|2446198_2448475_-\|glycoside-hydrolase-family-65-protein	gnl\|CDD\|237517	PRK13807, PRK13807, maltose phosphorylase; Provisional.	0
NZ_CP010525.1\|WP_043052469.1\|2422237_2423647_-\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	1.22253e-169

>NZ_CP010525.1|WP_026683812.1|2432467_2432902_+|Rrf2-family-transcriptional-regulator
MRLTHYSDYALRELIYLASLEEGKLASIKEIADAYNISKNHLMKITYELSKLGLIKTVRGRGGGICLNKHPREINVGKLIRITEDDFKLVECMEDGASACIISPVCGLKHVLNEALIAYLRVLDKYTLEDLVKDPLSYRQLLVK
>NZ_CP010525.1|WP_026683813.1|2431081_2432293_-|NO-inducible-flavohemoprotein
MLSQKTIEIVKSTVPVLKTQGTDITTYFYKTMFAAHPELLNIFNQTNQSRGRQQTALANAVLAAASYIDHLETILPVVEQISQKHRGLGVKPEHYPIVGEFLLKAIKEVLGDVATEEVLQAWAEAYGAIADVFIQVEKKMYQEAETQRGGWDGFKPFRVVKKVKESNVITSFYLKPTDGGPVPSYLPGQYLTLRVKIPGETYLFNRQYSLSCGPGHEYFRISVKREADHEPNGKVSTYLHDQVKVGDELEISVPAGVFTLDDEAAPIALISGGVGLTPMMSMLEALADASSKREVHFIHAARNEEFHAFKEEAKHHIEKLENGHYYFGYGHPLHENSGCDFTGHLSKAFLEKIVTTQTVCYICGPVPFLRNAVQILTELGVAKENIRYEFFGPAMELAPAAAV
>NZ_CP010525.1|WP_017552138.1|2430074_2430827_+|sulfite-exporter-TauE/SafE-family-protein
MHVSILITMFLTGLILGFIGAGGAGFIISLLTILFGVSIHTALATALTAMIFSSFSGAVSHYREGNVSIKAGITTGIIGAAGAWAGSHVSAHIASSELKWLTAGMLMFSAFLLWLRMFLLQKQSIQAKTLPFGPRFVTRSLLLGIVTGALSGMFGIGSTPFIQLGLMILLGLSVRQAAGTTMMVIIPIAIGGGLASFQQGTLDLGLLVEVVIGTMSGAYIGAKFTNRAPVSLLKSSMIAVPIVASLLLIL
>NZ_CP010525.1|WP_080666392.1|2428745_2429192_+|DNA-starvation/stationary-phase-protection-protein
MYIETALNVQVANWSVLYTKLHHYHWYVKGPLFFTLHVKFEELYNEAATVVDDFAERILAIGGKPAASFKEYLEIATIEEAKSGLTAEQMVESLVKDYKQIAGELKKLIALAEDNHDYGTADMATTLVESVEKTIWMLSALLAVPVTQ
>NZ_CP010525.1|WP_014095646.1|2427204_2428191_+|Gfo/Idh/MocA-family-oxidoreductase
MRFATVGTSWITSAFIEAAKLSGKLTLEAVYSRKKESAEQMAEKHGAPNMFTDLEEMAKNENIDAIYIASPNALHFEQVLVFLKNKKHVICEKPIFSNTEEFKEAFRVADQNGVFLFEAIRNIHYPNTALLKEKLKDVGQIRTGIFQYVQYSSRYDKFLAGEEPNVFSRNFSGGALMDLGVYPLSLAVWLFGAPKDSRYFPVLLRNGIDGAGTLVLQYEGFNITVICSKISHSYIPSEIHGEKGSIIIEGISELEKMKFADVRTKEPVLFSRKQEAQNMMYEINDFADIIAQNDRKTYETLRQSSYEVLSVIEKSRKQNGIVFKTDRN
>NZ_CP010525.1|WP_017552144.1|2425873_2426950_-|PAS-domain-containing-protein
MGVGKIHYEFMDLPLRFHLFSAVVGMDGILKSISSDMQTVTGFDAGDWVGRPFSALMHHDDRNKWVGILNGEKEEMGLFMYRMKSKNGDYKWVESTYAIFKDLKYGEKPHIHLLTKDMTVVKELYDYLVSSEQLSMVGQLAAGIAHEIRNPLTSIKGFLQLMQAGVIDTGNYLDIMQNEIERIEMISSELLFLGRPKASDMKVCCLQTLLDEVLVLMETQSYGKNIQIETVFPSQPIFISCDDSKMKQVFVNLIKNGLEAMEEGGTLTVELSVAEERAAVAIRDEGIGIPPEKLEKIGQPFYTTKERGNGLGLMVCYQIVREHNGDISIESKPGEGTVFTVVLPWAGPDGEQEASGSF
>NZ_CP010525.1|WP_035181970.1|2424088_2425657_-|peptide-chain-release-factor-3
MAGFEDEVLSRRTFAIISHPDAGKTTLTEKLLLFGGAIRAAGTVKGKKTGKFATSDWMEIEKQRGISVTSSVMQFEYAGKRINILDTPGHQDFSEDTYRTLMAVDSAVMIIDAAKGIEAQTIKLFKVCRMRGIPIFTFINKLDRQGRPPLELLAELEEILGIESYPMNWPIGMGKEFLGIYDRYHRRIEQFRVEEGDRFLALNEAGEVEGDAPIKENALYGQALEEIMLLDEAGNEFSEKRIANGTLTPVFFGSALTNFGVQTFLETYLQFAPPPQGRKTDEGVVDPLSEQFSGFVFKIQANMNPAHRDRIAFIRICSGKFERGMSVTLARTGKQMKLSQSTQFLADDRSTVEEAVSGDILGLYDTGTYQIGDTIFSGKQPVQFEKLPQFTPELFVKVSAKNVMKQKSFHKGINQLVQEGAIQLYRTWHTEDYILGAVGQLQFEVFEHRMKNEYNSDVVMESIGSKIPRWVEGDTVDESLSSSRSLLVKDRFGKPLFLFENDFALRWFTDKHPDIKLYNPMN
>NZ_CP010525.1|WP_043052469.1|2422237_2423647_-|group-II-intron-reverse-transcriptase/maturase
MKVTEETNKCRKQEETCCQKDTAEQEGYGRGHSFKRITENNTTNTNRQNEWMLERILSSNNLHRAYKKVKKNKGAGGVDGMKTGELLAYLTEHQRELVLSIRNGTYKPQPVRRVEIPKDNGKTRKLGIPTVVDRVIQQAISQVLVPIYERKFSDNSYGFRPHRSTHQALLKCQKNVNEGYQYVVDLDLEQYFDTVNHSKLIQILSETIHDGRVISLIHKFLNAGVMIKGIRTTNDFGVPQGGPLSPLLANVMLNELDKEMEARNHRFVRYADDVIIFCKSRRSCERTYHNILPFIEKKLRLKVNREKTMITHIRNIKFLSYGFYLYEGKCKFRVHPKGVQKLKEKIRRITGRSNGLSVEERKKRLNDTVRGWVNYYKLADMKSLVTRLDQWTRRRMRMVTWKRWKRVRTRFYWLKKLGINKRKAWEWANTRKGYWRISGSHILARTLTNELFRRARYISFLDYYLSVRS
>NZ_CP010525.1|WP_014095643.1|2421604_2422075_-|hypothetical-protein
MKKLAPLEAIVWNIALPGFAQLLAGRYVKGIMFLFMEFLINVNSRFNEAIMLSFLGRTREAGNIVDYGWLMFYPCLYFFAMWDAYKMARGNLQPYSYLPFVFAAYFVTLGLMLSPAVIVRQKMPGPVFFPMLCTIPGLLAGGLLRIILTRKSHKNS
>NZ_CP010525.1|WP_014095642.1|2420476_2421280_-|TerC-family-protein
MDLSMLFEYAWVLCVLVGLEGILAADNAVVMAVMVKHLPHAQQKKALFYGLLGAFVFRFTALFLISFLANIWQIQAVGAAYLFFIMIHHFVKKHRENGPKLAEAASKPVSFWMTVFKVELADIAFAIDSMLAAVAMAVTLSPAGSFQIGGINGGQFSVMFLGGVIGLVLIRFAANRFVRLLEKYPGLEDAAFLIVGWVGVKLLVFTLSHPGVGLIDEHFPESALWKLIFWAVMLAIAAGGYFFSVRKKNRNKEAQSAGKSGKKQQQM
>NZ_CP010525.1|WP_035181974.1|2433491_2434253_+|fumarylacetoacetate-hydrolase
MLKEAFLNTLYDAYKNRKALNKDVFPAGIDLDEAYRMQHAFTAAKKENHETLNGYKISMTSPETQALFDAREPLYGELTDQQVTNHISLSKDTLNPLIELELVFLVKERLTADASEAEIIQKTQVAPGLEIPDSRFKDWFPKMPKEQVCADGAVGGKVAFGEAKDYTYGDIDNIHGQLLLNGKVLDEGKSSAVMGHPVHAVKWLLKKLGEHQAALEPGMFVSSGTFVLPKPLEAGTYSGKFEGIGTVKLTVTE
>NZ_CP010525.1|WP_035181975.1|2434474_2434750_-|hypothetical-protein
MHIEGNVIKGEFDKNRNEFSLQHVKQFVTSSTINANQFRSLYDYLKKHRDDHEGQILTLYDQMPVHLSAEDIHLFIEDLEKLQPLYHPEGM
>NZ_CP010525.1|WP_014095656.1|2435183_2436107_+|SDR-family-oxidoreductase
MNIYEQQKNGQPAQTQPEQPGIESLMNPRPVQPLNYKGSEKLKGRVALITGGDSGIGRAVAIAYAKEGANVAINYLNEQNDAEETKSLVEAEGVQCLLLPGDVSQEATCKQLVEKTVAEFGKLDILVNNAGVQFPTEKIEDITHEQWDKTFRTNIYSVFYMCKYAVPHLKQGSAIISTASINPYVGNPKLLDYTATKGAIVGFTRSLAQNLASKGIRVNMVAPGPIWTPLIPSTFDEKTVESFGLKTPLGRPGQPADHAGAYVLLASDEGAYITGQCIHVNGGMAMSSDGKKLQKIFSAVFLTLPPK
>NZ_CP010525.1|WP_014095657.1|2437438_2438857_-|MFS-transporter
MVFNKKKINIVNIRQTKKSVFATGVGNAMEWFDFGLYSYLAVIISRNFFSAVENDELKLMFTFATFAIAFLMRPLGGVIFGRIGDKYGRKVVLTITIILMAFSTLLIGLLPTYDQIGIWAPVLLLVARIIQGFSTGGEYAGAMVYIAESSPDNKRNVLGSGLEIGTLAGYILASLLASTLFITLTDQQMATWGWRIPFLLGLPLGLVGFYLRAHLEETPIFENELSVEGVQEESFLSILKNHKKDILVCFVSVAFFNVTNYMLLSYMPSYLDEVIGLSSTAGTVLITLIMVIMVPLALLFGKLSDQIGNKTVLIMGLGGLTLLSVLAFYFIHLNTIAFVFLGILILGILLSTYEGTMPGTLPTMFYTDIRYRTLAVTFNVSVSLFGGTTPLISTWLVHQTGNALAPAFYLTFFSLIGFFVILFLFTSTSGKSLKGSYPTVATKTEYKEAIENPRHSLWWLMEKQEENKRLYN
>NZ_CP010525.1|WP_035181978.1|2439515_2440505_-|lactate-dehydrogenase
MRKVVAYETRADEFPLFQKFARKFDLDIKYVDDVLTPETAVEAKGAEAVTILGNYPVGAETFMALRDAGVKYIGLRTAGYNHIDQEAAKAYGIRFSNVAYSPYCVADFATMLILMCVRKAKQILSRVEAQDFSVEGIQGREMHNLTIGIIGAGRIGSIVAKNLSGFGCNIIAHDTVERDELRGILKYVSLDELLKESDVITIHTPLFDRTYHMINQDRIAKMKDGVCIINCSRGAVVDTDALIAGIEAGKVGAAGIDVLEDEEGIFHYDRRTDILAHHQLAILRSFPNVIVTPHTAFYTDQAVSDMVEMALTSLVSFMETGKSRWEIKS
>NZ_CP010525.1|WP_035181979.1|2441168_2441462_-|TIGR04197-family-type-VII-secretion-effector
MGEIKLNVELFNSNIEQLQAAVSDMETNLIKTTSFDQTNINPFKEELKQVTKAMELLSKYKSILEADIQTLKNTGEAIKKLDEQIEKSYVNYRKLQQ
>NZ_CP010525.1|WP_035181980.1|2441712_2441895_-|hypothetical-protein
MDEMVHTLMNQKSRLSSQKIHIQQDLADINAKIKRLKSALGELEKEISNLQDKAKPILNF
>NZ_CP010525.1|WP_035181982.1|2445280_2445970_-|beta-phosphoglucomutase
MRSFHDIKGFAFDLDGVLTDTARFHAQAWKKTAEEVGTKWTDELAAGLKGISRMDSLEMILKAGNCEHSYTHEQKAQLADEKNEYYKKLIDTLTPEDILPGMAEFLMEVKHKGYKLAVASASKNAPIILERLGIADMFDAVVDPAALKSGKPDPEIFVRAAELMNLQPCEVIGLEDSIAGIKSINGAGEVSVGIGDKDELYEAAIHFASTAEVSLSTIQGDPYFSKSNL
>NZ_CP010525.1|WP_035181983.1|2446198_2448475_-|glycoside-hydrolase-family-65-protein
MKRIFEVQPWNVVSHDFNRAEKRLQESMTSLGNGYMGMRGFFEENYSGDTLPGIYLGGVWFPDRTRVGWWKIGYPEYFGKVINAINFIKINIALNGEFIDLAKDEITGFELNLDMKNARLTRSFTVEKGTVKVVVTFERFLSVAQKELSVQRVRLKNLGSDDVDVKIISAIDADVKNEDANYGERFWEVLQTDQKEQSGSLVAITKANPFGTPRFTVGAEMHHRTALQAKVAAPAHDKEVVNGFSGKLVAGSEIDFEKRVIVVTSRDYHTQNNLVSAMNAISEKTDNLSYDELFDAHRAIWAERWEKSDVKIEGDVAAQQGIRFNLFQMFSTYYGEDARLNIGPKGFTGEKYGGATYWDTEAFALPFYLGVAEPKISKNLLKYRYQQLDGAYHNAKKQGLKGALFPMVTFDGIESHNEWEITFEEIHRNGDIAFAIYNYTRYTGDKSYVLNEGSKVLTEISRFWADRVHFSKRKQKYMLHGVTGPDEYENNVDNNWYTNYMARWTLAYTLQVLEEVSQEQAAVLNVTEEEKQLWQDIVDRMYLPEDEELGIFVQHDGFLDKDIKPVSEIPADELPINQHWSWDKILRSAYIKQADVLQGIWNFIDEFTPEQKKRNFDFYEPLTVHESSLSASIHAILASDLHDENKAVEMYERTSRLDLDNYNNDTEDGLHITSMTGSWLAIVQGFAGMRVRDGKLHFAPFLPKKWDKYQFRLLFRGRLIEVGVDTNGVSLELLEGEPLTVGLYGKDVELVAQSSVFV
>NZ_CP010525.1|WP_172653431.1|2448500_2449829_-|SLC45-family-MFS-transporter
MDSHQLPALPISTIWMISFGFLGVQMAFSLQSSNMGRIFQTIGADPTKLGFFFILPPLAGLVVQPLVGYFSDRTWIPKLGRRIPYLLVGAAVAVIVMCLLPNAGSFGFGFGSITALTFGAVTILFMDLSSNVAMQPFKMMVGDMVNEEQKGFAYAVQSFLSNSGAVLACIFPFVLTALGVSNSAPKGVVPQSVVVSFYSGAVILIVCSLFTVFKVKEYSPDEYAVYHGIQNQAQKEKMGMFQLLLNAPKEFWTITVVQFFCWMGFQYLWTYGAGAVAKNAWNAVDPSSTAYQEAANWFGVLSGVYSLAAVFWSLVLTKVPKNKQKPAYAFSLVLGGVGFGSVFFIHNPGTLLVSFILIGIAWAAMMAFPFTILTNALSGENMGTYLGLFNGSICLPQIVASCLSFLIFPALGSSMPAMILLSGVLLVIGAASVSLIKTTQTK

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Crispr_ID: NZ_CP010525_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_10

2497570-2497802

Orphan

Consensus_repeat	Method
TTTTGAANCTGNCAAAAGGACAAAA	CRT

4 spacers

The CRISPR arrays of NZ_CP010525_10

>merge|NZ_CP010525|10|2497570-2497802|CRT
TTTTGAAGCCGTCAAAAGGACAAAACACGCTGCTTCCGGGTCCAAAATGTCTTTTTGAACCTGCCAAAAGGACAAAACACGTTACGTCTGGATCCGAAATGTCCCTTTGAACCTGCCAAAAGGACAAAAAAAGGATCGCGTTTGGGCCCAAATATCCTTTTGAACCTGTCAAAAGGACAAAAGGAGTCGCGACTGGATCAAAATGTCTTTTTGAAGTTGCCACACGGACAAAA

>NZ_CP010525|10|2|2497570-2497802|CRT
TTTTGAAGCCGTCAAAAGGACAAAA	CACGCTGCTTCCGGGTCCAAAATGTCT
TTTTGAACCTGCCAAAAGGACAAAA	CACGTTACGTCTGGATCCGAAATGTCC
CTTTGAACCTGCCAAAAGGACAAAA	AAAGGATCGCGTTTGGGCCCAAATATCC
TTTTGAACCTGTCAAAAGGACAAAA	GGAGTCGCGACTGGATCAAAATGTCT
TTTTGAAGTTGCCACACGGACAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_035182027.1\|2502148_2502853_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372932
NZ_CP010525.1\|WP_017551449.1\|2496293_2497469_-\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NZ_CP010525.1\|WP_014095699.1\|2493902_2494331_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
NZ_CP010525.1\|WP_014095708.1\|2501154_2501511_-\|DUF1360-domain-containing-protein	unknown	unknown	gnl\|CDD\|369207
NZ_CP010525.1\|WP_014095703.1\|2498325_2498682_-\|stage-V-sporulation-protein-AE	unknown	unknown	gnl\|CDD\|131886
NZ_CP010525.1\|WP_017551778.1\|2498109_2498241_-\|YjcZ-family-sporulation-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_019721857.1\|2489995_2490154_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_014095700.1\|2494507_2494762_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_014095697.1\|2492585_2493317_+\|esterase-family-protein	unknown	unknown	gnl\|CDD\|225256
NZ_CP010525.1\|WP_014095706.1\|2500363_2500828_-\|sporulation-protein	unknown	unknown	gnl\|CDD\|293740
NZ_CP010525.1\|WP_014095698.1\|2493384_2493897_+\|2'-5'-RNA-ligase-family-protein	unknown	unknown	gnl\|CDD\|184236
NZ_CP010525.1\|WP_014095704.1\|2498860_2499871_-\|stage-V-sporulation-protein-AD	unknown	unknown	gnl\|CDD\|183504
NZ_CP010525.1\|WP_035182016.1\|2489785_2489983_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035182029.1\|2503121_2503820_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378716
NZ_CP010525.1\|WP_014095695.1\|2491584_2491788_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_014095705.1\|2499870_2500347_-\|stage-V-sporulation-protein-AC	unknown	unknown	gnl\|CDD\|131885
NZ_CP010525.1\|WP_035182031.1\|2503950_2504730_-\|enoyl-ACP-reductase-FabI	unknown	unknown	gnl\|CDD\|236308
NZ_CP010525.1\|WP_014095701.1\|2494863_2495121_-\|stage-VI-sporulation-protein-F	unknown	unknown	gnl\|CDD\|372899
NZ_CP010525.1\|WP_164931345.1\|2491113_2491284_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_014095709.1\|2501659_2502100_+\|Spore-coat-protein-Z/Y	unknown	unknown	gnl\|CDD\|371163

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_035182027.1\|2502148_2502853_-\|hypothetical-protein	gnl\|CDD\|372932	pfam14153, Spore_coat_CotO, Spore coat protein CotO. Bacillus spores are protected by a protein shell consisting of over 50 different polypeptides, known as the coat. This family of proteins has an important morphogenetic role in coat assembly, it is involved in the assembly of at least 5 different coat proteins including CotB, CotG, CotS, CotSA and CotW. It is likely to act at a late stage of coat assembly.	2.95748e-55
NZ_CP010525.1\|WP_017551449.1\|2496293_2497469_-\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	1.32007e-144
NZ_CP010525.1\|WP_014095699.1\|2493902_2494331_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.86897e-20
NZ_CP010525.1\|WP_014095703.1\|2498325_2498682_-\|stage-V-sporulation-protein-AE	gnl\|CDD\|131886	TIGR02839, stage_V_sporulation_protein_AE, stage V sporulation protein AE. This model describes stage V sporulation protein AE, a paralog of stage V sporulation protein AC. Both are proteins found to present in a species if and only if that species is one of the Firmicutes capable of endospore formation, as of the time of the publication of the genome of Carboxydothermus hydrogenoformans. Mutants in spoVAE have a stage V sproulation defect. [Cellular processes, Sporulation and germination].	4.44589e-45
NZ_CP010525.1\|WP_014095697.1\|2492585_2493317_+\|esterase-family-protein	gnl\|CDD\|225256	COG2382, Fes, Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism].	3.37518e-77
NZ_CP010525.1\|WP_035182029.1\|2503121_2503820_+\|hypothetical-protein	gnl\|CDD\|378716	pfam11780, DUF3318, Protein of unknown function (DUF3318). This is a bacterial family of uncharacterized proteins.	0.000123992
NZ_CP010525.1\|WP_014095709.1\|2501659_2502100_+\|Spore-coat-protein-Z/Y	gnl\|CDD\|371163	pfam10612, Spore-coat_CotZ, Spore coat protein Z. This family has members annotated as Spore coat protein Z, otherwise known as CotZ, It is a cysteine-rich spore coat family, and along with CotY is necessary for assembly of intact exosporium.	3.22293e-25
NZ_CP010525.1\|WP_014095698.1\|2493384_2493897_+\|2'-5'-RNA-ligase-family-protein	gnl\|CDD\|184236	PRK13679, PRK13679, hypothetical protein; Provisional.	2.38816e-91
NZ_CP010525.1\|WP_014095706.1\|2500363_2500828_-\|sporulation-protein	gnl\|CDD\|293740	cd16016, AP-SPAP, SPAP is a subclass of alkaline phosphatase (AP). Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Although SPAP is a subclass of alkaline phosphatase, SPAP has many differences from other APs: 1) the catalytic residue is a threonine instead of serine, 2) there is no binding pocket for the third metal ion, and 3) the arginine residue forming bidentate hydrogen bonding is deleted in SPAP. A lysine and an asparagine residue, recruited together for the first time into the active site, bind the substrate phosphoryl group in a manner not observed before in any other AP.	0.00612061
NZ_CP010525.1\|WP_014095708.1\|2501154_2501511_-\|DUF1360-domain-containing-protein	gnl\|CDD\|369207	pfam07098, DUF1360, Protein of unknown function (DUF1360). This family consists of several bacterial proteins of around 115 residues in length. Members of this family are found in Bacillus species and Streptomyces coelicolor, the function of the family is unknown.	2.28073e-49
NZ_CP010525.1\|WP_014095704.1\|2498860_2499871_-\|stage-V-sporulation-protein-AD	gnl\|CDD\|183504	PRK12404, PRK12404, stage V sporulation protein AD; Provisional.	0
NZ_CP010525.1\|WP_014095705.1\|2499870_2500347_-\|stage-V-sporulation-protein-AC	gnl\|CDD\|131885	TIGR02838, stage_V_sporulation_protein_AC, stage V sporulation protein AC. This model describes stage V sporulation protein AC, a paralog of stage V sporulation protein AE. Both are proteins found to present in a species if and only if that species is one of the Firmicutes capable of endospore formation, as of the time of the publication of the genome of Carboxydothermus hydrogenoformans. Mutants in spoVAC have a stage V sproulation defect. [Cellular processes, Sporulation and germination].	4.21495e-68
NZ_CP010525.1\|WP_035182031.1\|2503950_2504730_-\|enoyl-ACP-reductase-FabI	gnl\|CDD\|236308	PRK08594, PRK08594, enoyl-[acyl-carrier-protein] reductase FabI.	1.98596e-165
NZ_CP010525.1\|WP_014095701.1\|2494863_2495121_-\|stage-VI-sporulation-protein-F	gnl\|CDD\|372899	pfam14069, SpoVIF, Stage VI sporulation protein F. The sporulation-specific SpoVIF (YjcC) protein of Bacillus subtilis is essential for the development of heat-resistant spores. Its expression is governed by SigK.	1.01951e-23

>NZ_CP010525.1|WP_017551449.1|2496293_2497469_-|IS256-family-transposase
MTHLQFNLNLDVLKEAIMTSDLDAVIKSAVVLVLNEFMEKERDDYLKTSPYERAVERRDYRNGYYERELLMSIGNVTLKVPRTRNGEFSTTLFEKYARCDQAFVLSMLEMVINGVSTRKVTNVVEQLCGKNVSKSFVSSLTQKLDPIVNAWAERPLNTTYYPYVFVDAMYIKVREHHKVISKAVYIATAITEKNTREILGLSVDHAESLESWSSFFKQLKSRGLQSPKLVISDAHMGLQKAIQREFIGTAWQRCNVHFKRNIIEKLPKKDTAEIRVMIKRVFEAVTIEDIRKFKDELINKFGTEARFEKALAILDEGFEDTIQYMNFPENIRMHIRSTNSLERLNQEVRRRERVIRIFPNTQSAFRLVGAVLMQYQDTEYSKRKSLMGKNS
>NZ_CP010525.1|WP_014095701.1|2494863_2495121_-|stage-VI-sporulation-protein-F
MDHQFFKNIEKKTGVNMNDIFQLANSLQNANFKDENTVRGIIQRVSQIANKRVPKELEDKIVESIVKDGKKLDFNTINKMMNNGK
>NZ_CP010525.1|WP_014095700.1|2494507_2494762_-|hypothetical-protein
MSLIAPIPDYQASQYRLYDGMSLRQLEVEKADAVSRAYPVKRQNGVTGGTEYHFKANEQPGRKPAKSRIIAKITGLGQYIDLSV
>NZ_CP010525.1|WP_014095699.1|2493902_2494331_+|GNAT-family-N-acetyltransferase
MDVIIVENEEQLETAFQIRKKVFVEEQHVPVEEEIDALEQDCTHFLLYDDEGKPSGAGRFRMVDGYGKVERICILPSVRGKGAGRELMLAIEHYAAEQGVQKCKLNAQTHAIPFYEKLGYRVVSGEFLDAGIPHKAMEKTIK
>NZ_CP010525.1|WP_014095698.1|2493384_2493897_+|2'-5'-RNA-ligase-family-protein
MNYALVVFPSKKLQDLVNSYRKRYDPKYALIPPHITLKAAFEASEEEAEVFRGQLKEIAKKYNPFLLKVTKVKSFEPVSNTIYFKVEPTPELEGLFADFRDRLPGGPPPYPFVPHITIGQELSKEEHADVFRQLEMVGIDHEEKVNRFHLLYQLENGVWTVYETYHLGKD
>NZ_CP010525.1|WP_014095697.1|2492585_2493317_+|esterase-family-protein
MEIERGTIKDVPFESRELGETLNLWVYLPARFSPLYKYAVCICQDGKDFFQLGRIARAADELLAKGEIEDLIIVGIPYADIPDRRRKYHPDGEQHGAYIRFLAHELVPFLDREFPTAQMASDRALAGDSLAATVSLMAAFKYPHTFGKAALMSPLVNEKVMEAAKQCTDPKLLDIYHIAGKGETEVKTTDGKIQNFITPNRTLHQVLEEKGVPGFYDEFDGDHSWRYWQKDLPRALKYLFKKD
>NZ_CP010525.1|WP_014095695.1|2491584_2491788_+|hypothetical-protein
MDKNNKPYSDRRWTDPIGITEDGEISAISIGTKHYASEEERQRDIEEGKKIRKEFLKMLKERHKNNK
>NZ_CP010525.1|WP_164931345.1|2491113_2491284_+|hypothetical-protein
MGKKEKLFSAPRWTEPIGLKSDGSPSAISSGTKHYETEEERQKDIETTRYIREMLK
>NZ_CP010525.1|WP_019721857.1|2489995_2490154_-|hypothetical-protein
MEIKIGQVYKEKQHETLAMVVAVQNESIMLGTGNLVSPKTIEDRYVLVRDAE
>NZ_CP010525.1|WP_035182016.1|2489785_2489983_+|hypothetical-protein
MKTVVKFCLTLVLAYFINQLISRIFAYYLPEEGAGAIFIPILIFSFCLLAGYAIVGYIFKIAAKK
>NZ_CP010525.1|WP_017551778.1|2498109_2498241_-|YjcZ-family-sporulation-protein
MFGYGYGGGCGYGGYGGGYGYGSTFVLIVVLFILLIIVGASFC
>NZ_CP010525.1|WP_014095703.1|2498325_2498682_-|stage-V-sporulation-protein-AE
MLAMFFWAFVIGGLICVIGQLLFDVAKLSPGHTMSVLVTAGAILSGLGLYEPLVNFAGAGATIPITSFGNSLATGAMQEVQRHGIVGVLTGMFEVTSSGISAAIIFGFIGSLLFKPRG
>NZ_CP010525.1|WP_014095704.1|2498860_2499871_-|stage-V-sporulation-protein-AD
MPAKSQTWTFTNRPAILSTGVVGGPFEKKGQMADDFDRFFEDLWIGEDSYEKAQRKLIEEAVGIALKKRNLKETDIQFFLAGDLINQITPTSFAARTNAIPYLGLFSACATSMESLALAAFIVNHGGAEKVLAGASSHNATTEKQFRYPTEYGGQKPPTAQWTVTGAGFAVVGTEENGPAPRITSATIGKVLDLGISDPFNMGGAMAPAAVDTIEQHLRETGRDPSYYDLIVTGDLAKIGRSIALDLFKQRNLDIRSEQFQDCGLMVYDKSQPVQAGASGAGCSAIVLYGHLLNEMKKGRYQKILLVATGALLSPLSYQQGETIPCIAHACAIEYL
>NZ_CP010525.1|WP_014095705.1|2499870_2500347_-|stage-V-sporulation-protein-AC
MANKNQNKTPEQKAYDQFEKKHELKRPVLKNCIRAFWVGGCFCLAGQALTYFYIYMFNFTEKTAGNPTTATMVFLSMLLTGFGIYDHIGQYAGAGSAVPVTGFGNSVVSAAIEHRTEGYVLGVGGNIFKLAGTVIVFGVFSAFVVVLIRTVIMMWGGS
>NZ_CP010525.1|WP_014095706.1|2500363_2500828_-|sporulation-protein
MKKIMYVLASVCLLTGCGFNGPEHKDSKMALVKKTQPSPVRLTNTGNKAVSGQLKKDVLGFDSIYDVAIIEGPKETLVAYKVRHLHRFKMKKIEKQLNAFLKKRYPGRKFITSSDYKIFLETVRLKEDMDEHKISAGKAKKRFKDIIKLKQELT
>NZ_CP010525.1|WP_014095708.1|2501154_2501511_-|DUF1360-domain-containing-protein
MVSYWLDFVLLALASFRLTRLLVYDKITAFLRKPFHKEITEMAPDGTIEEYIEIKGTGIRKWIGELLSCHWCTGVWSAAILYGSWMLFPQIGSPIVMILAIAGLASILETVLLRIMDE
>NZ_CP010525.1|WP_014095709.1|2501659_2502100_+|Spore-coat-protein-Z/Y
MSSKSHEYSRTCVCDVVHFINDLQDAAVEDSSCPTNCLNPVLGANREKHSHVNTRPFILYTKDGCAFEPFYKNHHFDSCDDFCEKSKFLRVENVEGCCAVVRVLKCVCEHHDGHSRVHFEATDTCITLDLTDFIAIQCLEDTFVNL
>NZ_CP010525.1|WP_035182027.1|2502148_2502853_-|hypothetical-protein
MEESQYSSQKPLLYIIQPKNVPLAIKMQKVYRNVVSEKTEHAGHGTIAEPMPASGDTGHAEEKNNAAAREKKTEPEQPKPNKAVEQEKTEEAAERGGAVNVSFKTKTADPAEHEESANAMGQQHVAEPAGAVEAETDLETDGADKADTWPEQETVQPPSRKRFKEMTVHEKIDYLIHKPGFLPEIPVMIQTNSIAYRAVILERMEDQLSVMPFSSMETAWINLDEITDIKLLVQ
>NZ_CP010525.1|WP_035182029.1|2503121_2503820_+|hypothetical-protein
MSYYDSNDSCYDDHRHHKRQDEEERGLLSEFDVDQSPSVPVSVTGVFNMANAIAEVDVKVDDYDDRVSLLATVEWSPADLPLGVTLAALIGAITGAGPGIVIPLTIPAVFRIWRRNSSGTTLISQKRDESGISGIGILTAGGLVTVLFENVTTTVHAVDTDPSKGKNEYFLTIELGNFAPDTTIPGVAPTLLGTITLTPQNVVSYTFSAAEIEDNDHYHYDNKKGHKKNYRD
>NZ_CP010525.1|WP_035182031.1|2503950_2504730_-|enoyl-ACP-reductase-FabI
MQLSLENKTFVVMGVANKRSIAWGIAQSLDAAGARIIFTYALDRNEKSIHELAETLNRKDYLILQCDVESDEQIQSCFQTIKKEAGTIDGIAHCVAFARREELKGDYTNVTREGFLLAHNISSYSLSAVAKAVKELELMPNGGSIVTLTYLGGERVMENYNVMGVAKASLDASVRYLAYDLGKLNIRVNSISAGPIRTLSAKGVSDFNSILKVMEERAPLHRGVDTREVGDTALFLFSDLSRAVTGENIHVDAGYHIMG

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Crispr_ID: NZ_CP010525_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_11

2513689-2513763

Orphan

Consensus_repeat	Method
AAGACATTTTCACGGTCTCGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_11

>merge|NZ_CP010525|11|2513689-2513763|CRISPRCasFinder
AAGACATTTTCACGGTCTCGGGCTCGCGTTTTGTCCTTCATCAACCCGGTGAAGGACATTTTCACGGTCTCGGGC

>NZ_CP010525|11|11|2513689-2513763|CRISPRCasFinder
AAGACATTTTCACGGTCTCGGGC	TCGCGTTTTGTCCTTCATCAACCCGGTGA
AGGACATTTTCACGGTCTCGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_017551790.1\|2507676_2508471_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|235317
NZ_CP010525.1\|WP_172653433.1\|2515768_2516617_+\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|372699
NZ_CP010525.1\|WP_014095727.1\|2520721_2521381_-\|adaptor-protein-MecA	unknown	unknown	gnl\|CDD\|235030
NZ_CP010525.1\|WP_035182043.1\|2510266_2511061_+\|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|381594
NZ_CP010525.1\|WP_035182029.1\|2503121_2503820_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378716
NZ_CP010525.1\|WP_014095722.1\|2515361_2515763_+\|globin	unknown	unknown	gnl\|CDD\|381281
NZ_CP010525.1\|WP_014095729.1\|2523358_2524420_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP010525.1\|WP_035182039.1\|2509165_2509549_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035182041.1\|2509685_2510270_+\|CYTH-domain-containing-protein	unknown	unknown	gnl\|CDD\|143627
NZ_CP010525.1\|WP_155375938.1\|2511820_2511967_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035182049.1\|2517363_2519178_-\|oligoendopeptidase-F	unknown	unknown	gnl\|CDD\|341071
NZ_CP010525.1\|WP_014095724.1\|2517078_2517267_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_172653432.1\|2508507_2509143_-\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232
NZ_CP010525.1\|WP_014095730.1\|2524438_2525458_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP010525.1\|WP_013858789.1\|2521740_2522136_-\|transcriptional-regulator-Spx	unknown	unknown	gnl\|CDD\|179316
NZ_CP010525.1\|WP_035182031.1\|2503950_2504730_-\|enoyl-ACP-reductase-FabI	unknown	unknown	gnl\|CDD\|236308
NZ_CP010525.1\|WP_035182036.1\|2506795_2507668_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP010525.1\|WP_014095726.1\|2519245_2520466_-\|competence-protein-CoiA	unknown	unknown	gnl\|CDD\|226875
NZ_CP010525.1\|WP_035182034.1\|2504941_2505679_+\|bis(5'-nucleosyl)-tetraphosphatase-PrpE	unknown	unknown	gnl\|CDD\|184187
NZ_CP010525.1\|WP_162488825.1\|2522415_2523351_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224048

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_017551790.1\|2507676_2508471_-\|NAD-kinase	gnl\|CDD\|235317	PRK04885, ppnK, inorganic polyphosphate/ATP-NAD kinase; Provisional.	4.58592e-179
NZ_CP010525.1\|WP_172653433.1\|2515768_2516617_+\|DsbA-family-protein	gnl\|CDD\|372699	pfam13743, Thioredoxin_5, Thioredoxin.	2.73675e-93
NZ_CP010525.1\|WP_014095727.1\|2520721_2521381_-\|adaptor-protein-MecA	gnl\|CDD\|235030	PRK02315, PRK02315, adaptor protein MecA.	6.64902e-78
NZ_CP010525.1\|WP_035182043.1\|2510266_2511061_+\|lytic-transglycosylase-domain-containing-protein	gnl\|CDD\|381594	cd00254, LT-like, lytic transglycosylase(LT)-like domain. Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	7.15813e-50
NZ_CP010525.1\|WP_035182049.1\|2517363_2519178_-\|oligoendopeptidase-F	gnl\|CDD\|341071	cd09608, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3B oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and includes oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity. The PepF gene is duplicated in L. lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid. This PepF family includes Streptococcus agalactiae PepB, a group B streptococcal oligopeptidase which has been shown to degrade a variety of bioactive peptides as well as the synthetic collagen-like substrate N-(3-[2-furyl]acryloyl)-Leu-Gly- Pro-Ala in vitro.	0
NZ_CP010525.1\|WP_014095722.1\|2515361_2515763_+\|globin	gnl\|CDD\|381281	cd14772, TrHb2_Bs-trHb-like_O, Truncated hemoglobins, group 2 (O); Bacillus subtilis TrHb like. The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. TrHbs are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). TrHb2's belonging to this group include monomeric Bacillus subtilis trHb (Bs-trHb), which exhibits an extremely high oxygen affinity, and a dimeric TrHb2 from the thermophilic aerobic spore forming bacterium Geobacillus stearothermophilus(Gs-trHb).	1.94288e-70
NZ_CP010525.1\|WP_035182029.1\|2503121_2503820_+\|hypothetical-protein	gnl\|CDD\|378716	pfam11780, DUF3318, Protein of unknown function (DUF3318). This is a bacterial family of uncharacterized proteins.	0.000123992
NZ_CP010525.1\|WP_035182041.1\|2509685_2510270_+\|CYTH-domain-containing-protein	gnl\|CDD\|143627	cd07762, CYTH-like_Pase_1, Uncharacterized subgroup 1 of the CYTH-like superfamily. Enzymes belonging to the CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) superfamily hydrolyze triphosphate-containing substrates, require metal cations as cofactors, and have a unique active site located at the center of an eight-stranded antiparallel beta barrel tunnel (the triphosphate tunnel). The name CYTH originated from the gene designation for bacterial class IV adenylyl cyclases (CyaB) and from thiamine triphosphatase. Class IV adenylate cyclases catalyze the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. Thiamine triphosphatase is a soluble cytosolic enzyme which converts thiamine triphosphate to thiamine diphosphate. This domain superfamily also contains RNA triphosphatases, membrane-associated polyphosphate polymerases, tripolyphosphatases, nucleoside triphosphatases, nucleoside tetraphosphatases and other proteins with unknown functions. Proteins of this subgroup are of bacterial origin and have not been characterized.	4.28329e-79
NZ_CP010525.1\|WP_014095729.1\|2523358_2524420_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	0
NZ_CP010525.1\|WP_172653432.1\|2508507_2509143_-\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	9.23065e-100
NZ_CP010525.1\|WP_014095730.1\|2524438_2525458_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.27897e-98
NZ_CP010525.1\|WP_013858789.1\|2521740_2522136_-\|transcriptional-regulator-Spx	gnl\|CDD\|179316	PRK01655, spxA, transcriptional regulator Spx; Reviewed.	1.14015e-85
NZ_CP010525.1\|WP_035182031.1\|2503950_2504730_-\|enoyl-ACP-reductase-FabI	gnl\|CDD\|236308	PRK08594, PRK08594, enoyl-[acyl-carrier-protein] reductase FabI.	1.98596e-165
NZ_CP010525.1\|WP_035182036.1\|2506795_2507668_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.24314e-98
NZ_CP010525.1\|WP_014095726.1\|2519245_2520466_-\|competence-protein-CoiA	gnl\|CDD\|226875	COG4469, CoiA, Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only].	3.30832e-53
NZ_CP010525.1\|WP_035182034.1\|2504941_2505679_+\|bis(5'-nucleosyl)-tetraphosphatase-PrpE	gnl\|CDD\|184187	PRK13625, PRK13625, bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional.	3.8685e-162
NZ_CP010525.1\|WP_162488825.1\|2522415_2523351_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	1.17911e-127

>NZ_CP010525.1|WP_155375938.1|2511820_2511967_+|hypothetical-protein
MTHLQFNLNLDVLKEAIMTSDLDAVINKNLLHQNFNLFFKFHKTFCIL
>NZ_CP010525.1|WP_035182043.1|2510266_2511061_+|lytic-transglycosylase-domain-containing-protein
MSTISQLASLMELEALQSLSPGSNAAQTANSTSLFQEMLSSFLEEAKKNETAAGASGKDESGALSALAATLNPAFNSLSSLTGGNSVLTTLPASQGLSTLSGKETSAAAQAGTSAAFSASAQNSASESTQTTAASGSGGIPAKISQAIQQASEKYGVPEKLIQAVIKQESGYRPDAVSAAGAAGLMQLMPETAASLGVSNVLDPEQNVDAGTKYLKSLLGKYDHNVQLALAAYNAGPGNVDRYGGIPPFKETQKYVSSIMNHLA
>NZ_CP010525.1|WP_035182041.1|2509685_2510270_+|CYTH-domain-containing-protein
MSKEIEIECKNMVTRRDFCRLARAFCIAEHDFKQQENFYFDTPDFALKHKKSALRVRKKAGCFQLTLKTPEETGLLETSQMIGEKVFQKLKNGSGFPEGEVMEKLMELEVTPSKLVYFGKLTTKRAEIAYKGGLLVFDHNFYLNEEDFEIEYEVSELETGTKQFLKLLETYGIPHHPAKNKVLRFYEAKRSNEK
>NZ_CP010525.1|WP_035182039.1|2509165_2509549_-|hypothetical-protein
MRKIIELGQPEWKDGILELHSERPDVSMQHLKPGGQMIVDSDACAFIYLAEDDGDEDYTYLYLPVPVWKEIRTAAFEHKKVVAVSKDGKLELTGLDEELQFLLDNIRGNSNYGKKMLDKVEAVFALE
>NZ_CP010525.1|WP_172653432.1|2508507_2509143_-|GTP-pyrophosphokinase-family-protein
MDWEEFLTPYKQAVDELKVKLKGMRTQFEKEHTHCPIEFVTGRVKPVASIIEKANIKGIPLDRLEAEMQDIAGLRMMCQFVDDIKLVVGLLRRRNDFRIVEEKDYISNKKPSGYRSYHVIIEYPVQTIRGEKKILAEIQIRTLAMNFWATIEHSLNYKYKGRFPEEINLRLKRAAEAAFRLDEEMSEIREEIQEAQMYFSKNKERAERKKP
>NZ_CP010525.1|WP_017551790.1|2507676_2508471_-|NAD-kinase
MKFAITSKGDTESNIWMHKMRSYLQDFGLVYDEAQPDIVISVGGDGTLLYAFHRYSSRLDRTAFVGVHTGHLGFYADWVPDEIEELVDAIAHKTYTTVDYPLLEVMIAYEHGGHETRYLALNESTVKCVDGTFVIDVEINGRHFERFRGDGLCLATPSGSTAYNKALGGAIVHPSLQSIQLTEMASINNKVFRTIGSPLILPGHHTCVLRPVRQKDFLVTVDHLTLLHKEVRSIQYRVAKEKIRFARFRPFPFWKRVHDSFISD
>NZ_CP010525.1|WP_035182036.1|2506795_2507668_-|RluA-family-pseudouridine-synthase
MLTLSWTITEDEAHQELKEFLKTRHISKRALADIKFRGGLILVNGREVTVRYRLQPGDAAAIVFPKETPSPNLTPENIPFGLVYEDESVLVADKPAFMNTIPSREHPSASLANAVLGHYRKNGIESAVHVVTRLDRNTSGLVLIAKNRYIHHLCSLMQQKHVICRTYEALAEGTFTEKSGTIEAPIGRKETSIIEREVRDDGQFARTHYEVVRQFPAYAHVRLRLDTGRTHQIRVHLSYIGHPLLGDSLYGGNTSRFTRQALHCSELSFQHPVSGKEMHFLSKPPFLDLL
>NZ_CP010525.1|WP_035182034.1|2504941_2505679_+|bis(5'-nucleosyl)-tetraphosphatase-PrpE
MKIDIIGDIHGCMAEFRKLTEKLGYQWENGMPVHPGGRLLGFVGDLTDRGPASLEVADTVYRLWKKKLGLYVPGNHCNKLYRYFLGRNVQQKHGLETTVAELEALPVKERERHSKQFMELYEKSPLYLVLDGGKLVIAHAGIRRKDIGKMNKSVQTFILYGDINGETNPDGTPVRRDWAKNDEGEGWIVYGHTPVKEPRLIGHTVNIDTGCVFGGKLTALRYPEIETVSVPSSMPYVEEKFRTFA
>NZ_CP010525.1|WP_035182031.1|2503950_2504730_-|enoyl-ACP-reductase-FabI
MQLSLENKTFVVMGVANKRSIAWGIAQSLDAAGARIIFTYALDRNEKSIHELAETLNRKDYLILQCDVESDEQIQSCFQTIKKEAGTIDGIAHCVAFARREELKGDYTNVTREGFLLAHNISSYSLSAVAKAVKELELMPNGGSIVTLTYLGGERVMENYNVMGVAKASLDASVRYLAYDLGKLNIRVNSISAGPIRTLSAKGVSDFNSILKVMEERAPLHRGVDTREVGDTALFLFSDLSRAVTGENIHVDAGYHIMG
>NZ_CP010525.1|WP_035182029.1|2503121_2503820_+|hypothetical-protein
MSYYDSNDSCYDDHRHHKRQDEEERGLLSEFDVDQSPSVPVSVTGVFNMANAIAEVDVKVDDYDDRVSLLATVEWSPADLPLGVTLAALIGAITGAGPGIVIPLTIPAVFRIWRRNSSGTTLISQKRDESGISGIGILTAGGLVTVLFENVTTTVHAVDTDPSKGKNEYFLTIELGNFAPDTTIPGVAPTLLGTITLTPQNVVSYTFSAAEIEDNDHYHYDNKKGHKKNYRD
>NZ_CP010525.1|WP_014095722.1|2515361_2515763_+|globin
MVEKKTVPYEIIGGEKLGRLVDAFYKRVAKHPDLIPIFPDDLTEVARKQKQFLTQFLGGPPLYTEEHGHPMLRARHLPHEVTPKRAKAWLSCMSAAMDETGIDGEFRDFFFQRLVLTAQHMVNTPDDVPGDAN
>NZ_CP010525.1|WP_172653433.1|2515768_2516617_+|DsbA-family-protein
MIDLMKHSSCFSKKPLEIYVFIDPLCPECWALEPVLKKLRLEYGVYFRLRHVLIGKLSNLNDIPKKREAIADYWEKTASRTGMSCDGSLWIENPITSPYIVSIAIKAAELQGKKQGLRFLRKVQELVFLEKRNISDIQILVDCAKGASIDVDEFLHDIHSESAAKAFQCDLKITSEMEVTESPSLVFFNEHIEDEGLKISGLYSYDIYVQVLQEMLGKEPSPLPLPPLEEFLKYFGFVASKEIAVVYDLPVHEAEKELKKLVLQQKVRKIEGKHGSFWKYIN
>NZ_CP010525.1|WP_014095724.1|2517078_2517267_+|hypothetical-protein
MKKCKLIALAAGFCALFCLNLLGLMKLLPLFLTSTLLFAAIFALLLHVNRRNRFKGFNRRHL
>NZ_CP010525.1|WP_035182049.1|2517363_2519178_-|oligoendopeptidase-F
MENGKKVHALPSRDEVREALTWRLEDIFPSDDDWNKEYQTVKEKLADAASYQGKLGESAEQLYHALKFQDEVTERFGKLYTYAHMRYDQDTTNAFYQGIDSKAKSLAAQVGSAFAFVVPEILSIEEAKLNQFLEAYEPLQLYRHALEEINEMRPHILSKEEEALLAQVSEVLNTSSTTFGMLNNADLEFPTVIDENGNEVQITHGRFTRLLESKDRRVRKEAFQKLYATYKKFSNTFASTLSGQVKKNNVVAQIRHYHSAREAALSANHIPEKVYDQLVETVNKHLGLLHRYVALRKKALQLDEVHMYDLYTPLVQDADMEVTYEKAKEIVLDGLHPLGEEYRSILQQAFENRWIDVVENKGKRSGAYSSGAYGTNPYILLNWQDNIDNVFTLAHELGHSVHSYYTRKNQPYPYGDYSIFVAEVASTCNEALLNDYLLKTIKDEKQRIYLLNHYLEGFRGTVFRQTMFAEFEHLIHQKAQHGEALTAELLTDEYYKLNQKYYGTDTAIDQEIGLEWARIPHFYYDYYVYQYATGFSAATALSKQILEEGEPAVKRYIGYLSAGSSEYPIEVLKKAGVDMTSPQPVEDALKVFEEKLTEMENLLG
>NZ_CP010525.1|WP_014095726.1|2519245_2520466_-|competence-protein-CoiA
MLSALNERGELIMLTERFTRLDLKQLKTSHTFYCRDCREPLILKIGSRVTPHFSHYRHSTCATFSEPESPMHLQGKKDLFLWLRGQGLDVSLEQYFPSIRQRADLVVRKYRQLFAIEYQCSPIPFERLMERTEGYRHLGILPVWILGGMPFRSSGKEAESVYRCSDFQLSFLRHTRHHFYLFSYPPGKKKVCLLSHMTPISAKTFHACYAEKPLSAFSFPFTDDQFSFVSAPVPLPEWFAERRRWIGLKIQFGKAFQDPFLRHVYEAGMHPGSLPPFIGLPLLHMAACKQHPVEWQFYIWLDALFALRTKAAVSLDELLRLFTVRMEKKEIAFRKSPYVRERNAAKAMIYEYAQLLVQLGLWSKGKAGYYMNKNVFAPKNTEELEHMERHLSSVLGAGVSTGKAEQ
>NZ_CP010525.1|WP_014095727.1|2520721_2521381_-|adaptor-protein-MecA
MEIERINENTVKFYISYVDIEKRGFNREEIWYDRERSEELFWEMMDEIHTDDDVFDPEGPLWIQVQALEKGLEVLVTKAQLSKDGQRFELPIPDEKLKELPIGDQLEEFFSENFQTPMQQVFTDGDPLEQVLYFKDFEDLLALAKNVRMEDVSTKLYVFEGKYYLYVRFPEDVTEEANDFKLSQLLEYSDLSSVTSHRLLEYGKPIIDSNVFAKLNSYF
>NZ_CP010525.1|WP_013858789.1|2521740_2522136_-|transcriptional-regulator-Spx
MVTLYTSPSCTSCRKARNWLEENHIEYKERNIFSEPLSLDEIKGILRMTEDGTDEIISTRSKTFQKLNVDLDALPLQELYTLIQQNPGLLRRPIIVDEKRLQVGYNEDEIRRFLPRKVRTFQLREAQRLVN
>NZ_CP010525.1|WP_162488825.1|2522415_2523351_-|ATP-binding-cassette-domain-containing-protein
MKEKLIEVKHLKQYFNVGKANEVRAVDDLTFDIYKGETLGLVGESGCGKSTTGRTIIRLYNATAGEVLYGGKNVHAKMSHKELKHFRRKMQMIFQDPYASLNPRLKVADVIAEGIDIHGLAKSNEERMHRVYELLETVGLSKEHANRYPHEFSGGQRQRIGIARALAVDPEFIIADEPISALDVSIQAQVVNLLKKLQKEHDLTYLFIAHDLSMVKYISDRIGVMYFGKLVELADADDLYNHPHHPYTQSLLSAIPLPDPDYERTRQRKIYDPSVHQYKEGEEVKMREVAPHHFVYCSERELEQYKKTYHG
>NZ_CP010525.1|WP_014095729.1|2523358_2524420_-|ABC-transporter-ATP-binding-protein
MEKILQVKDLNISFHTFGGEVKAIRGVSFDLYKGETLAIVGESGSGKSVTTKSIMRLLPPNNSEIKSGQILFGDVDIAKASERKMQSIRGKEISMIFQDPMTSLNPTMTIGKQIMEPLLKHQKMHKSEAKKRAIELLKLVGIPNAEIRVKQYPHQFSGGMRQRVVIAIALACNPKILIADEPTTALDVTIQAQILELMKKLQSKIDTSIIFITHDLGVVANVADRVAVMYGGKIVEIGTVDEIFYNPKHPYTWGLISSMPSLDVKDEELYAIPGTPPDLLNPPKGDAFAPRNPYALKIDLEQEPPMFKVSDTHYAATWLLHPDAPKVEPPEAVKKRMYKFKGNVRPIPAEEGK
>NZ_CP010525.1|WP_014095730.1|2524438_2525458_-|ABC-transporter-permease
MNNNVETLPKELFEPAAPDREQSELIAKPQLSFMQDAWMRIRKNKGAVASLFVIVILILMAIIGPHLSKSGPYAQDTSRANLPPRIPVIEKLGIFDGSQTVGGQKVNMYEQNHIHTYYWFGTDALGRDLFARAWQGTRISLYIAFLAALIDMLIGVSYGLISGYKGGQVDNVMQRIIEILSGIPNLIVVILMLLIFKPGIFSITIAMVITGWLNMARVVRGQVLKLKNMEYVLAAKTLGASNMRILFKHLLPNLTGVIIINTMFTIPSAIFFEAFLSFIGIGLQSPAASLGTLIEDGYKTFQFLPYLMAVPGTIICLLLVAFNLLADGLRDAFDPKMRD

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Crispr_ID: NZ_CP010525_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_12

2599171-2599263

Orphan

Consensus_repeat	Method
TGCTTGTGCGTTTCACCGCCGTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_12

>merge|NZ_CP010525|12|2599171-2599263|CRISPRCasFinder
TGCTTGTGCGTTTCACCGCCGTGTTGAAATTAGGAAAAAGACGACTACGGCCAGGACAAACTGGTTTACTGCTTGTGCGTTTCACCACCGTGT

>NZ_CP010525|12|12|2599171-2599263|CRISPRCasFinder
TGCTTGTGCGTTTCACCGCCGTGT	TGAAATTAGGAAAAAGACGACTACGGCCAGGACAAACTGGTTTAC
TGCTTGTGCGTTTCACCACCGTGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_017550233.1\|2609143_2610277_-\|DUF445-domain-containing-protein	unknown	unknown	gnl\|CDD\|226834
NZ_CP010525.1\|WP_172653434.1\|2604539_2605433_-\|permease	unknown	unknown	gnl\|CDD\|223773
NZ_CP010525.1\|WP_014095797.1\|2598139_2599084_-\|3'-5'-exoribonuclease-YhaM	unknown	unknown	gnl\|CDD\|237394
NZ_CP010525.1\|WP_017550228.1\|2596495_2596588_-\|YjcZ-family-sporulation-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_014095795.1\|2595616_2595946_-\|YhaI-family-protein	unknown	unknown	gnl\|CDD\|370213
NZ_CP010525.1\|WP_014095805.1\|2606693_2607476_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|236073
NZ_CP010525.1\|WP_026683724.1\|2593871_2594060_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234609
NZ_CP010525.1\|WP_035182125.1\|2594528_2594891_+\|YtxH-domain-containing-protein	unknown	unknown	gnl\|CDD\|227313
NZ_CP010525.1\|WP_014095804.1\|2606503_2606689_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379480
NZ_CP010525.1\|WP_035182103.1\|2593303_2593828_+\|tryptophan-transporter	unknown	unknown	gnl\|CDD\|293704
NZ_CP010525.1\|WP_035182107.1\|2596887_2597760_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|101162
NZ_CP010525.1\|WP_014095807.1\|2608602_2608950_-\|YlbF-family-regulator	unknown	unknown	gnl\|CDD\|237467
NZ_CP010525.1\|WP_014095803.1\|2605663_2606443_+\|TerC-family-protein	unknown	unknown	gnl\|CDD\|163429
NZ_CP010525.1\|WP_014095806.1\|2607618_2608485_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|319818
NZ_CP010525.1\|WP_035182105.1\|2595035_2595602_+\|HTH-type-transcriptional-regulator-Hpr	unknown	unknown	gnl\|CDD\|237501
NZ_CP010525.1\|WP_017550232.1\|2603672_2604527_-\|TIGR03943-family-protein	unknown	unknown	gnl\|CDD\|226214
NZ_CP010525.1\|WP_013858718.1\|2597808_2598003_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|290852
NZ_CP010525.1\|WP_017550231.1\|2602279_2603551_-\|DNA-repair-exonuclease	unknown	unknown	gnl\|CDD\|277319
NZ_CP010525.1\|WP_014095791.1\|2592657_2593071_+\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611
NZ_CP010525.1\|WP_017550230.1\|2599295_2602283_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|227061

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_017550233.1\|2609143_2610277_-\|DUF445-domain-containing-protein	gnl\|CDD\|226834	COG4399, COG4399, Uncharacterized protein conserved in bacteria [Function unknown].	7.07983e-91
NZ_CP010525.1\|WP_172653434.1\|2604539_2605433_-\|permease	gnl\|CDD\|223773	COG0701, COG0701, Predicted permeases [General function prediction only].	7.91245e-70
NZ_CP010525.1\|WP_014095797.1\|2598139_2599084_-\|3'-5'-exoribonuclease-YhaM	gnl\|CDD\|237394	PRK13480, PRK13480, 3'-5' exoribonuclease YhaM; Provisional.	0
NZ_CP010525.1\|WP_014095807.1\|2608602_2608950_-\|YlbF-family-regulator	gnl\|CDD\|237467	PRK13676, PRK13676, YlbF/YmcA family competence regulator.	2.44198e-30
NZ_CP010525.1\|WP_014095795.1\|2595616_2595946_-\|YhaI-family-protein	gnl\|CDD\|370213	pfam08963, DUF1878, Protein of unknown function (DUF1878). This domain is found in a set of hypothetical bacterial proteins.	5.90444e-46
NZ_CP010525.1\|WP_014095805.1\|2606693_2607476_-\|enoyl-CoA-hydratase	gnl\|CDD\|236073	PRK07659, PRK07659, enoyl-CoA hydratase; Provisional.	2.02653e-121
NZ_CP010525.1\|WP_017550231.1\|2602279_2603551_-\|DNA-repair-exonuclease	gnl\|CDD\|277319	cd00840, MPP_Mre11_N, Mre11 nuclease, N-terminal metallophosphatase domain. Mre11 (also known as SbcD in Escherichia coli) is a subunit of the MRX protein complex. This complex includes: Mre11, Rad50, and Xrs2/Nbs1, and plays a vital role in several nuclear processes including DNA double-strand break repair, telomere length maintenance, cell cycle checkpoint control, and meiotic recombination, in eukaryotes. During double-strand break repair, the MRX complex is required to hold the two ends of a broken chromosome together. In vitro studies show that Mre11 has 3'-5' exonuclease activity on dsDNA templates and endonuclease activity on dsDNA and ssDNA templates. In addition to the N-terminal phosphatase domain, the eukaryotic MRE11 members of this family have a C-terminal DNA binding domain (not included in this alignment model). MRE11-like proteins are found in prokaryotes and archaea was well as in eukaryotes. Mre11 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.42175e-56
NZ_CP010525.1\|WP_035182125.1\|2594528_2594891_+\|YtxH-domain-containing-protein	gnl\|CDD\|227313	COG4980, GvpP, Gas vesicle protein [General function prediction only].	2.64701e-13
NZ_CP010525.1\|WP_014095804.1\|2606503_2606689_-\|hypothetical-protein	gnl\|CDD\|379480	pfam14120, YhzD, YhzD-like protein. The YhzD-like protein family includes the B. subtilis YhzD protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved GKL sequence motif.	1.39029e-29
NZ_CP010525.1\|WP_035182103.1\|2593303_2593828_+\|tryptophan-transporter	gnl\|CDD\|293704	pfam17099, TrpP, Tryptophan transporter TrpP. TrpP is a bacterial transmembrane protein that is probably involved in tryptophan uptake. Its expression is regulated by tryptophan-activated RNA-binding regulatory protein (TRAP).	1.67395e-38
NZ_CP010525.1\|WP_035182107.1\|2596887_2597760_+\|peptidylprolyl-isomerase	gnl\|CDD\|101162	PRK03002, prsA, peptidylprolyl isomerase PrsA.	1.14019e-65
NZ_CP010525.1\|WP_014095803.1\|2605663_2606443_+\|TerC-family-protein	gnl\|CDD\|163429	TIGR03717, R_switched_YjbE, integral membrane protein, YjbE family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family commonly are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains protein YjbE from Bacillus subtilis. A transport function is proposed.	3.55194e-70
NZ_CP010525.1\|WP_014095806.1\|2607618_2608485_-\|HAD-family-phosphatase	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	6.52902e-64
NZ_CP010525.1\|WP_035182105.1\|2595035_2595602_+\|HTH-type-transcriptional-regulator-Hpr	gnl\|CDD\|237501	PRK13777, PRK13777, HTH-type transcriptional regulator Hpr.	1.65484e-104
NZ_CP010525.1\|WP_017550232.1\|2603672_2604527_-\|TIGR03943-family-protein	gnl\|CDD\|226214	COG3689, COG3689, Predicted membrane protein [Function unknown].	1.80849e-83
NZ_CP010525.1\|WP_013858718.1\|2597808_2598003_-\|hypothetical-protein	gnl\|CDD\|290852	pfam14147, Spore_YhaL, Sporulation protein YhaL. This family of proteins is involved in sporulation. In B. subtilis its expression is regulated by the early mother-cell-specific transcription factor sigma-E.	1.6484e-19
NZ_CP010525.1\|WP_026683724.1\|2593871_2594060_-\|hypothetical-protein	gnl\|CDD\|234609	PRK00068, PRK00068, hypothetical protein; Validated.	0.00819369
NZ_CP010525.1\|WP_014095791.1\|2592657_2593071_+\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	2.07848e-57
NZ_CP010525.1\|WP_017550230.1\|2599295_2602283_-\|AAA-family-ATPase	gnl\|CDD\|227061	COG4717, COG4717, Uncharacterized conserved protein [Function unknown].	2.87939e-118

>NZ_CP010525.1|WP_014095797.1|2598139_2599084_-|3'-5'-exoribonuclease-YhaM
MAKGLLYYEVGEQFDAFLLIKHATKGIASNGKPFLTLILQDRTGDIEAKLWDATEQDEQTYKPETIVKVTGDILNYRGRLQLKIRQIHPAQPGDGVRISDFIETAPLSQEEMMGKITQYIFDMKNPNIQRLTRHLLKKYQKRFLVYPAATKNHHEFVSGLAYHVVSMLDLAKAIAGLYPSLDRDLLYAGVILHDLGKVQELSGPISTTYTAEGNLLGHISIMVTEIAKAAEELGIHGEEVMVLEHMVISHHGKAEWGSAKPPMIKEAEILHYIDNIDAKMNMLDRALRNVKPGEFSDRIYALDNRSFYKPTFHQ
>NZ_CP010525.1|WP_013858718.1|2597808_2598003_-|hypothetical-protein
MDFPIWIYFVVAGIVICAFMAVKTAREEHEQEQEWIEKEGEVFIERMHKEKELRSGEAEKAHEA
>NZ_CP010525.1|WP_035182107.1|2596887_2597760_+|peptidylprolyl-isomerase
MKKWVLSLVLAGSMFGLAACGNSGNSAVVKTNAGNVTKDELYNAMKDKYGSTVLQQLTIEKVLSKKYTVKKSEIDKQVNDTKKQLGSSFNTALQQYGYANEKDFRNSVKIGLLEQKAAEATIHPTEKQLKNYYNNDIKPKIKARHILVSSKSKAEDIKKQLDKGADFATLAKKYSTDTATASKGGDLGWFGAGEMDSDFENAAYKLKVNEISGPVKTSYGYHIIQLTGEKQKKPYSEMKKDVVKQYKESKVTTEKIQSVLKKELKAADIKVKDEDLKTTFDPLLGTSSSK
>NZ_CP010525.1|WP_017550228.1|2596495_2596588_-|YjcZ-family-sporulation-protein
MSGGAAYGGGFALLVVLFILLIIIGASWAW
>NZ_CP010525.1|WP_014095795.1|2595616_2595946_-|YhaI-family-protein
MESIEQKLERLEFYQTLLLKMIGTSQYPFFRLIMEKQLSKQDIEQFYALCDRLSDELKEQKADKFVYFYPLFQKFKESLHEKLQPAEVIAACLQQGLYPDLMKALKRNL
>NZ_CP010525.1|WP_035182105.1|2595035_2595602_+|HTH-type-transcriptional-regulator-Hpr
MTEQMLTTNEYLLFCKRVTQLSKALWKTIEKDWQQWIRPFDLNINEHHILWIAYHLKGASISDVAKFGVMHVSTAFNFSKKLEERGLLEFSKKENDKRNTYIQLTNKGREIFLKSLEAFNPKKSTVVQGTMPLYDLYGKFPDMMELAAIVRQIYGQDFMDIVENSIFNGELDDVIETELLGKPSLNRF
>NZ_CP010525.1|WP_035182125.1|2594528_2594891_+|YtxH-domain-containing-protein
MNKSSLFYGLLVGATAGAVSVLFTTPASGKRIREAIKNNSGDFIESAKRIAENVKDLKASVEDFSIEGKKVATNVMEEIQHCIEEWQKSIEPNKDALQNEIKEIRKTIENMEQQMEKKSS
>NZ_CP010525.1|WP_026683724.1|2593871_2594060_-|hypothetical-protein
MGRVAFCFLMAGVVLFAAMVRHMLLYQKRRIYPPRKVIRKRIAFFGTAGMVFLLLAALFHLF
>NZ_CP010525.1|WP_035182103.1|2593303_2593828_+|tryptophan-transporter
MKTKSLVSLALLVGIGTVLHTVIPGFVFGMKPDMMLTMMFIGIILFKEKKYVLLLGVLTGIISGLTTSFPGGFFPNIIDKCITSFAFYGLLLASGKLAKKLPALIVFTAIGTLISGIIFLGSAFFIAGLPGPFAILFGTVVLPATVLNAVAMFILFPIISNVAKRTNAAHSMQA
>NZ_CP010525.1|WP_014095791.1|2592657_2593071_+|HIT-family-protein
MCIFCKIINGEIPSAKVYENEHVYAFLDISQVTKGHTLIVPKIHKENVYELTPEIARNFFESVPVVANALKAAFQPVGLNVLNNNGEIAGQSVFHYHMHLIPRYGKGDGFGAVWKTHEKDYSQEDLQQIAAEISKKI
>NZ_CP010525.1|WP_017550230.1|2599295_2602283_-|AAA-family-ATPase
MKIREVHIYGFGRLVDFHMENLSDLQVIYGENEAGKSTFMAFIEAVLFGFPSRQQNGQHYEPKFSPVYGGRLVLETEKDGKITVERIKGRAAGEVSVTFADGRTGGEEVLAQVLNGLNRQMFQSIYSFNLQSLQEIRKLTGDDISRYLFAAGTIGTDALLSAERELEKEMEARFKPNGRKPVLNVQLRKLQAMEKELNHLKAENGRYGEWKARLATIEAAQEEAEAELEALRGTVQQYEHLTSLWPLYAERKHIKLQLAEIGPVRFPADGIRRLDALMSEWRASTGRLSAVKKQKQVLVEKMEGEQPDPLFVRHEGEIKKLLDDWPQYRGWQAEAERLQSEREILDSQISELSGMLHLTASQVEKVPQLDLSIAAKERLSTLIKAYDHHRSRNDALQAQLEDLRARMNAVEQQCALLEKELVSEEAFRDLSAKRQEKEKKSLLEADIRRGKQQLSRLKKMADEARKPPVLFFGLALLFLMAGVWSLLTGQYLFLGVFVLGAIVSGYHALKGKRNPFEEEIRALEQELEEEEKELRNWKDGDTDWHEYERQKQLRENWKQLILKLEEGEQNGRQMQNRKQRLEAEERQLLAEISHFRQTLQLGDGFRPGQLPDAFQLLTDLSGKLRERSRIEKKLAQLSASQSAFAERMENLWSRLHVNWPLRQEGILLLQQACAEQQERKIRLQEWEKKCAELEEQLQLLESEAEATDKEIKKLFALAGAANEEDFRKAGSLFQQYEKLTGQLEIIDLRISREDLERLERIEDVSIFEQEKQKLEEKIAEKANALRSMRKEAAEIRFELDRLEKGGTFTEKLHEYYSALSDFREEAFEWARFATAKRLLSGMMKRLRETRFPQVLNKAEAYLQSLTNGSYVSLHMGGEDGRFYVKRRDDVLFAANELSQATAEQLYIALRFSLAEALGGEFPSPVVIDDGFVNFDIYRTEKMARLLDQVSESRQVLLFTCQQPMLRFFKGHEVKTLGAIHGQELTGSGNISRIQP
>NZ_CP010525.1|WP_017550231.1|2602279_2603551_-|DNA-repair-exonuclease
MEKCRLFFYERGMSLKRIRFVHAADLHLDSPFAGLRKLPPALFERVKESTFRAFKNLCDLTIEKEADFLLICGDLYDGEDRSLKAQVRLKKQFERLQEAGISVFVLHGNHDHLSGSWTKLDMPANVRIFSERVEAKSFTAKNGSKVHVYGFSYPKRHVLENKTDEYRKTGDADFHIGMLHGYLEGGTKMHQPYAPFALQDLLEKGMDYWALGHIHKQQILHTHPYIIYPGNIQGRNRKETGPKGCMVTEMDPLGTHTAFYETADILWEKRTVSVKGANDFNRLYTVCRNALEEERKEAQGVFLQLDIKDPDLLDDEALGKVKNGELMEVLQEGEEADRNFVWVHRITLPEDAFVSARDDGFILQEMKKTLAQLEETTVDEAVSPLYSHMVAGRYLDLDGDEKQRLLLEAEAAVFEKLKGRGKR
>NZ_CP010525.1|WP_017550232.1|2603672_2604527_-|TIGR03943-family-protein
MLRFIVLFGFAYFFMKLHATGDISKYINMKYAYLSFSMIFAMGFLCLYQLVKWVRAGNEAHDHHHAAHHGHSHETDENTWYKKMFTYGMILIPVVTGIFLPVATLNSTVVKAKGFHFSMIDNDKDQYANHQILRPNSSLYYDKDQYTEMESSDLKKYSKLQSIVLDDDHYFHGLETIYNYPGNFIGKKVAIKGFVYRTDDIKANQLFVLRFGIIHCIADAGVYGMLVDFPDNMANVKENTWIEVEGKLDTTYYTPFKENIPYLKVTSYHKSSEPKDPYVYRQYN
>NZ_CP010525.1|WP_172653434.1|2604539_2605433_-|permease
MGQSLLQMNTIFISIIIEALPFIVLGVFISAVIQMFVTEEMIAKVMPKNRFLSIAFGTGMGALFPACECGIVPITERLVRKNVPLSAAIAFMLTGPIINPVVIFSTFVAFGDSWKMALLRCGLAIFTAVLTAIAISYFFSENQLREFVEAKLHHHGHDHEAHDKPNFLQKITGTIDHAIDEFFSVGKFLVFGGLISAAMQTFFRTSTLLSLGQTKMAAILIMMLLAFIMSICSEADAFIASSFNGMFGTSAILAFLVFGAMVDIKNLLMMMHSFKRKFVFSMIGLIIVFVFTGAFLI
>NZ_CP010525.1|WP_014095803.1|2605663_2606443_+|TerC-family-protein
MKQLPVSIFDFGLVVSAGAFVALLKIIMIDIILSGDNAVVIAMATRKLQREQQNKAIFWGTAGAVILRILLAMAIVALLKIPYVNVIGGLLLLWIAYKVLGGGDENVHVRAKNGLLVSIGTIIMADAIMSLDNVVALAGASNGHIGMIALGVAISIPVMIFGSKMIVKAMNRYSWIAYVGSGILAWTAAEMLFKDEQILKWLNISHGPVTYTIGGILTVLVLFLGWLSNRRAAVKQVKQVKRDIKKDVKQDVQQRVHIH
>NZ_CP010525.1|WP_014095804.1|2606503_2606689_-|hypothetical-protein
MRDYKLTAFEPTGEKILDEGFEAQDDTEAKKKGEALLKEKGVDEKTHRCVSPEGKLILFHR
>NZ_CP010525.1|WP_014095805.1|2606693_2607476_-|enoyl-CoA-hydratase
MISTYETIKVEEKDGAAYLYFNRPDAMNALNLEMIKELADALKAIAMKDDIHILVLSGNGKAFSAGGDIKAMLAMEEEKGFTSFMNQINEAVSILVGMPKLTIAAINGAAAGLGLSLALACDTIISDLDSKIAMNFIGIGLVPDGGGHYLLQRRIGQEKAKKVIWEGKVMSAEEAAETGIIDEAVPDLALAVDQKITEWQKKPVLAMIKTKKIYTELNRPDFNKSLELEKHAQWKMRQTKDHKEGIRAFVEKRAPQFKGE
>NZ_CP010525.1|WP_014095806.1|2607618_2608485_-|HAD-family-phosphatase
MIYKMLALNIEGTLLQDNGRLGKTTKEAIEYAGAKGIAVTLITSKNFASAHRIAKWLKLHSSLITHQGAYIASELDKPIFVRRISEEATRDLVRFLEGFHAQIRLVSERFTLSNRVKHPNKLMGKVIYQTSNPFSYAEQYVDDLSAKLEQTPLSPPKIEVIFSDGEDIQAAKKAIANMFHEVDCIFCGNGKLDIVPAGISKLRGLLYVCDRMNIRREEVVVIGSGLDDLPLVEWAGLGVAMGNAHPAVKNVSDWVTRSNNENGVSYMVKEHFRKQQPIDFLKKMKLLK
>NZ_CP010525.1|WP_014095807.1|2608602_2608950_-|YlbF-family-regulator
MPSHLNEYARMLEKGIRESHEFAALKQAYENVRSNGQARALFDRFRQLQLNLQDKQMQGLLVTEEDEKQAQAAMQAVQSNPAIMQLIGAEQRLSDLLSEINQVLMRPVEDLYAGK
>NZ_CP010525.1|WP_017550233.1|2609143_2610277_-|DUF445-domain-containing-protein
MHAFLEILFMTVVGAVIGGFTNYLAIKMLFRPYEAIYIKNWRLPFTPGLIPKRREEIAKQLGEMVVRHLVTPESIEKKLLSPGFRKETARWMTDTFLKWLEMSWTAPQMARFFKVDLSAERVQTGIKAFIRTRYGQAKQHIAPQTLEALLPEAVIKKAEEKIPVLADLIIARISEYISSPAGRTKIEGMISHFLDDRGMIGAMVKRFIGNTSIADKIQPEIIRALQEPGMKATMAEMLEREWNGLKAKQAGELLPDLPDEEISGWLEKNVLSLLPVERFLDTPVQAFVARYRNKIEEEWIPVLAEKALHLISENVHLIIRKLQVADLVRQEVESFPIERLESLILGITAREFSMITYLGALLGGLIGIVQGVIVLLV

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Crispr_ID: NZ_CP010525_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_13

2821581-2821672

Orphan

Consensus_repeat	Method
CCAAAGGCTTTGCAAGGGCTAGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_13

>merge|NZ_CP010525|13|2821581-2821672|CRISPRCasFinder
CCAAAGGCTTTGCAAGGGCTAGAACTTAGAAATGAGATTGGCAGCGTAGAACTATTTACAACTTTGTCCAAAGGTTTTGCAAGGGCTAGAAC

>NZ_CP010525|13|13|2821581-2821672|CRISPRCasFinder
CCAAAGGCTTTGCAAGGGCTAGAAC	TTAGAAATGAGATTGGCAGCGTAGAACTATTTACAACTTTGT
CCAAAGGTTTTGCAAGGGCTAGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_014095982.1\|2832132_2832309_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035182323.1\|2815420_2816482_-\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176188
NZ_CP010525.1\|WP_035182330.1\|2820828_2821425_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_035182331.1\|2823160_2824489_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
NZ_CP010525.1\|WP_014095981.1\|2831470_2832052_+\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|376871
NZ_CP010525.1\|WP_035182328.1\|2819526_2820678_+\|radical-SAM/CxCxxxxC-motif-protein-YfkAB	unknown	unknown	gnl\|CDD\|275271
NZ_CP010525.1\|WP_014095973.1\|2821821_2822028_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_014095967.1\|2812432_2813392_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380509
NZ_CP010525.1\|WP_014095964.1\|2810455_2810641_+\|Fur-regulated-basic-protein-FbpA	unknown	unknown	gnl\|CDD\|315692
NZ_CP010525.1\|WP_035182320.1\|2809648_2810413_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224561
NZ_CP010525.1\|WP_014095966.1\|2811757_2812300_-\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|240138
NZ_CP010525.1\|WP_172653436.1\|2824628_2825423_+\|AAC(3)-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|376807
NZ_CP010525.1\|WP_035182340.1\|2830018_2830405_-\|MerR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133403
NZ_CP010525.1\|WP_014095974.1\|2822228_2822654_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP010525.1\|WP_014095965.1\|2810949_2811729_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319819
NZ_CP010525.1\|WP_043052586.1\|2825869_2826769_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235853
NZ_CP010525.1\|WP_035182325.1\|2816706_2819226_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP010525.1\|WP_035182336.1\|2826856_2828515_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173843
NZ_CP010525.1\|WP_172653417.1\|2806350_2807310_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381329
NZ_CP010525.1\|WP_035182338.1\|2828498_2830022_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|235730

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_035182323.1\|2815420_2816482_-\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176188	cd05285, sorbitol_DH, Sorbitol dehydrogenase. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. Aldose reductase catalyzes the NADP(H)-dependent conversion of glucose to sorbital, and SDH uses NAD(H) in the conversion of sorbitol to fructose. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The medium chain alcohol dehydrogenase family (MDR) have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	1.02091e-179
NZ_CP010525.1\|WP_035182331.1\|2823160_2824489_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	7.07445e-90
NZ_CP010525.1\|WP_035182328.1\|2819526_2820678_+\|radical-SAM/CxCxxxxC-motif-protein-YfkAB	gnl\|CDD\|275271	TIGR04478, radical_SAM_superfamily_domain_protein, radical SAM/CxCxxxxC motif protein YfkAB. Members of this highly conserved family in some Firmicutes have an N-terminal radical SAM domain (pfam04055) and a C-terminal pfam08756 domain with a CxCxxxxC motif that suggests binding to an additional metallocluster. It appears all correct sequences in this family are about 370 amino acids in length, containing the YfkA and YfkB regions originally reported as separate ORFs in Bacillus subtilis. Partial Phylogenetic Profiling shows occurrences almost exclusively in the Bacilli, with very few examples of either lateral transfer or gene loss. The essentially monophyletic distribution suggests a housekeeping function. Members have no well-conserved gene neighborhood. The function is unknown. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP010525.1\|WP_172653436.1\|2824628_2825423_+\|AAC(3)-family-N-acetyltransferase	gnl\|CDD\|376807	pfam02522, Antibiotic_NAT, Aminoglycoside 3-N-acetyltransferase. This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyze the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic. The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others.	8.10759e-114
NZ_CP010525.1\|WP_014095967.1\|2812432_2813392_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380509	cd06286, PBP1_CcpB-like, ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species. This group includes the ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species. Catabolite control protein B (CcpB) is 30% identical in sequence to CcpA which functions as the major transcriptional regulator of carbon catabolite repression/regulation (CCR), a process in which enzymes necessary for the metabolism of alternative sugars are inhibited in the presence of glucose. Like CcpA, the DNA-binding protein CcpB exerts its catabolite-repressing effect by a mechanism dependent on the presence of HPr(Ser-P), the small phosphocarrier proteins of the phosphoenolpyruvate-sugar phosphotransferase system, but with a less significant degree.	2.26256e-117
NZ_CP010525.1\|WP_014095964.1\|2810455_2810641_+\|Fur-regulated-basic-protein-FbpA	gnl\|CDD\|315692	pfam13076, Fur_reg_FbpA, Fur-regulated basic protein A. This family of proteins is regulated by the ferric uptake regulator protein Fur. This family does not regulate the lutABC operon encoding iron sulfur-containing enzymes necessary for growth on lactate.	5.7044e-08
NZ_CP010525.1\|WP_035182320.1\|2809648_2810413_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	4.7198e-42
NZ_CP010525.1\|WP_014095966.1\|2811757_2812300_-\|SIS-domain-containing-protein	gnl\|CDD\|240138	cd05005, SIS_PHI, Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.	3.66029e-41
NZ_CP010525.1\|WP_014095981.1\|2831470_2832052_+\|biotin-transporter-BioY	gnl\|CDD\|376871	pfam02632, BioY, BioY family. A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin. BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes.	3.72844e-35
NZ_CP010525.1\|WP_035182340.1\|2830018_2830405_-\|MerR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|133403	cd04776, HTH_GnyR, Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR. Putative helix-turn-helix (HTH) regulatory protein, GnyR, and other related proteins. GnyR belongs to the gnyRDBHAL cluster, which is involved in acyclic isoprenoid degradation in Pseudomonas aeruginosa. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	2.10382e-36
NZ_CP010525.1\|WP_014095974.1\|2822228_2822654_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	3.50502e-34
NZ_CP010525.1\|WP_014095965.1\|2810949_2811729_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|319819	cd07517, HAD_HPP, phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily. Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.7271e-91
NZ_CP010525.1\|WP_043052586.1\|2825869_2826769_-\|SDR-family-oxidoreductase	gnl\|CDD\|235853	PRK06701, PRK06701, short chain dehydrogenase; Provisional.	6.06011e-162
NZ_CP010525.1\|WP_035182325.1\|2816706_2819226_+\|ATP-binding-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.09693e-10
NZ_CP010525.1\|WP_035182336.1\|2826856_2828515_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173843	cd01154, AidB, Proteins involved in DNA damage response, similar to the AidB gene product. AidB is one of several genes involved in the SOS adaptive response to DNA alkylation damage, whose expression is activated by the Ada protein. Its function has not been entirely elucidated; however, it is similar in sequence and function to acyl-CoA dehydrogenases. It has been proposed that aidB directly destroys DNA alkylating agents such as nitrosoguanidines (nitrosated amides) or their reaction intermediates.	1.88429e-143
NZ_CP010525.1\|WP_172653417.1\|2806350_2807310_+\|aldo/keto-reductase	gnl\|CDD\|381329	cd19103, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	2.0137e-177
NZ_CP010525.1\|WP_035182338.1\|2828498_2830022_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|235730	PRK06187, PRK06187, long-chain-fatty-acid--CoA ligase; Validated.	2.56691e-166

>NZ_CP010525.1|WP_035182330.1|2820828_2821425_+|hypothetical-protein
MGWLIGIIIIILLVYFLIIRPLIERNRPQIIEPRRSIYNGDAYDPHPEQTGWNEGGNAGIGRFGMFAGGMATGALLTYLLEQGRIGLDQFEHFQNLDGNDLLQELEEQNILQQDEIDHLQDTLSNFEDNGHDGHEDGDHGDHDQQDTGFDLAHFSSHEDHDTHDNDQQDTGFDLADFSSNDDNDFGGWDSGSDDNNWL
>NZ_CP010525.1|WP_035182328.1|2819526_2820678_+|radical-SAM/CxCxxxxC-motif-protein-YfkAB
MLKEETQRSITPEYDPWEAYMDITTHGKLTLSNIEFTTTTLCNMRCEHCAVGYTLQPKDPDALPLDLLLRRLDEISTLRCISITGGEPMLSTKSVENYVLPLLQYAHERGIRTQINSNLTMKLEKYVQIVPYLDVLHISHNWGTVRDYIDGGFANMRIKPSDQHGEKMFRRIVENSRALSEMGVMVSAETMLNKRTLPYMEQIHHQIVEEMKCARHEIHPMYPSDFAADLEVLSLDEIREAIHHLLDIRDESVWMLFGTLPFYPCSTNPEDQALLKRLYESKNVTLRNDPDGRSRLNVNIFTGDVIVTDFGDTPPLGNIQHDRLPDVFEKWLKTPIAKSLNCHCPQVKCLGPNILVKNAYYKNIDFTQRKAVIDMQGASSRMG
>NZ_CP010525.1|WP_035182325.1|2816706_2819226_+|ATP-binding-protein
MAELENQKKFSSLLSSGVKALKQHPDYKTNREAGNKTGQSYMEKIAYKLGVSPNTVKSWIGQMGSKYIPGRIEDAKLFGIIWLILEKGCMNVTWFMELLETTSIPVIEPALPAWVASCLKKAKTMNDNGTIGTPPPEEINMVITRLFGNAAVLESEEKNKFSAHNLPARWSGRFIGRKSDLQAIYHWLLSPSPVCSITGWAGVGKTTLALEAAYACAGEPGEEAANVSDKWPAFHCIIWFSTHLTGLSFNDFLNTIAYQLGLTEQIDKPVMEKRFAVRHALQLFSREQPILLIVDSMDAAEKEVLEFIINLPQGVKAMLTSRENYNQDYKDAFQNFTIVKLKGLNEKEALSYLSFVIREHLQTGSAPNQEELRHLTPEMQAKLIKAAAGNPKALSLCIAYISDGGIPAEQLIQEIESAGYSLLELFEFLFGRTWKRIDEAARRLWQVLCFFEKPPVEAAWAAAAGLDARGFYAAVEQMRNYALIHPDRTDGKLRYPAHQTVIAYGEQHLSENRQLEKEARKRWARYYIHFLDTHLKREQPNIFYWRYLLGRDLDDLKQEWTNIRKVMEWASQSDEKEILIEFVVRTSHFLSRVNLPLRVEYGRKAADFAAALDKSMLEAFFRIDTVGWALMEMNELEEALIQIDAGLKRLSGLDAGNEDTRDLMVWGHALKSRVLLKAGDPDQAEAILSKVIPVPSTPMIRHRVLLVQGDLYLERKKYKEAIRAYEAANQISHAYGGEKTIEAYFNLGIAYVENQQFEKAAAAFEKMLYQKNKANPIELMYYHYGMARLFAKKGDLAYALYSSQEALHLAASWEQNISIRDETEKFNQFIKKKIQYQNG
>NZ_CP010525.1|WP_035182323.1|2815420_2816482_-|NAD(P)-dependent-alcohol-dehydrogenase
MTNHIPETMKAAVMHGTRNISIETLPVPQIEENEVLIKVMAVGICGSDLHYYETGRIGKYVVDKPFILGHECAGEIAAVGSKVRHFKVGDRVAVEPGVTCGHCEACKEGRYNLCPHVQFLATPPVDGAFCQYIKMREDFVFAIPDALSYEEASLVEPFSVGIHAATRTKLQPGSTVAIMGMGPVGLMAVVAARAFGASNIIVTDLEPLRLEAAKEMGATYAINIREQDPYEAIQDITNGKGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPAQNEIPLNVPFIADNEIDIYGVFRYANTYPKGIKFLASGIADVKKLVTDQYALEDTYQAMERALNFKNECLKVMVYPNN
>NZ_CP010525.1|WP_014095967.1|2812432_2813392_-|LacI-family-DNA-binding-transcriptional-regulator
MTNIRDLAKMAGVSVTTVSRVLNNHPYVSEEKKNAVLKAVKATRYHKNINAVHLSKGKTKLIGVVLPFTDHPYFALLLKGIAKQALEYNHKLLLFQTDYMESRETEALQMLQQKQIDGLIICSRACSMRKIEEYLPFGPIALCECVKGGEISSTYIDHYKIFMDALEFLYRKGHTKIGYCIGRKSGTNSRNRDKAYWDFHEKYHLPHHPEYIFDQCYDYEDGERVLSRVKEMDPPPSALLVTSDQVAAGIVISCNKQQISIPDELAIIGFDNEPIAGMLNITTIDIPLVEMGRNLVHQVLTKEIKNKEISATLIERGTV
>NZ_CP010525.1|WP_014095966.1|2811757_2812300_-|SIS-domain-containing-protein
MNILEDAKAMVLELYASLCSKVDDQPLEQVVEVIGRSNRLFLAGTGCSEMILRVFANRLVHLGFRVGMIGDLISPVPKKGDTILFSSKSGENPVLLNAARKAKLHGINIVAITASPASTLAKMADVTVLLPDESSEFESIKQAGLTPDRIGTLFELLSFLIYDVITASLMKKRHPENEYA
>NZ_CP010525.1|WP_014095965.1|2810949_2811729_-|Cof-type-HAD-IIB-family-hydrolase
MKQQSVIFFDIDGTLLTHEKKLPVTTKKAIDKLKSDGHVTAIATGRAPFMFEDLRKELGMDTFVSYNGQYVVMNGEVLFKNPLNRQSLEELTAYALSHQHPLVYMDHEDMKANVPNHEDIEKSITSLKIGRLPAYDPHYYKGRELYQALLFCSEGEEKQYEQAFPDFEFIRWHPLSVDVLPKGGSKARGIEKIVEKLGFPPERQYAFGDGLNDIKMLSMIKNSVAMGNAEEKVKAAAKYITKSVEDMGIPHGLQIVGLL
>NZ_CP010525.1|WP_014095964.1|2810455_2810641_+|Fur-regulated-basic-protein-FbpA
MKNFLRHAIEKKRQYLIEQLIALGAYQEDDKQLFTLTLTELETEYAYFSKISQEKEASGRE
>NZ_CP010525.1|WP_035182320.1|2809648_2810413_+|alpha/beta-fold-hydrolase
MHEYYPVLSGAESFFIKGNEIGILISHGFNGTPQSVRFLGEALVSDGFTVFAPRLKGHGTHILDMERCTYKDWIASLEEGYQLLKQHCRDIFVIGQSMGGTLALHLAEKHPDIQGIVCINAAIQSIPELEKCLAKGRFIQEGPPDIKAAGVHEISYEKVPVASIRELLSVMWETRENLSAIHCPALLFQSTEDHVVPPENTEYIAAHIHASRKKIVPLRNSYHVATMDHEKEWIAAQCSLFVQEIAHIETRTEI
>NZ_CP010525.1|WP_172653417.1|2806350_2807310_+|aldo/keto-reductase
MKMVQMQNDKIPPIALGTWSWGTGANGGDTVFGNHLTAADLKPVFDAAMDAGLNLWDTAAVYGMGASETILGRFIRERGDALISTKFTPGGEQDDNAVEAFLEGSLERLGVDHVDLYWIHNPGDVKRWTPKLIPLMKSGKIKHVGVSNHNLEEIKLAADILAAEGLKLSAVQNHYSLLYRSSEEAGILDYCNQNGILFFPYMVLEQGALTGKYGPQNPFPAGTRRGDAFTPDVLSKLEDLIRVMKKIGSKYETGPAQITIAWAIAKGTVPIIGVTKVSQIEDAVSAAEVHLTEQEIRELEAAAKATGVEIKGAWEKPMH
>NZ_CP010525.1|WP_014095973.1|2821821_2822028_-|hypothetical-protein
MNENKKKSQRKMDNPEQFATENEDMHDKFMSEQTVDPIPMEDLREEKLEEKTDHDKKTTSSSEKKYKP
>NZ_CP010525.1|WP_014095974.1|2822228_2822654_+|universal-stress-protein
MFNRILVAIDGSKMSEKALKSALNFAKERFTKIGVIHVEKNPVIPEGMPNASIDTLYSEQQRDGDDLLDQAAALAEEEEIEIEKFYETGDPAAQIVRKAEEGNYQLIIMGSRGLGNLKGLMLGSVSQKVTQLAKCPVLIIK
>NZ_CP010525.1|WP_035182331.1|2823160_2824489_-|polysaccharide-biosynthesis-protein
MAVFFKGAFMLIGVAFIGECIEFLTNMVLANELGAHGMGLYMSILPAIFLIVTIASMELPISISKFVAEQEEKYHRDMLRFTIRLASLFVLLLMAAVALLLPVLPIFHHYHPYLRWLIIALIPMIAFSSIARGYFMGVQQMGKIAAANFLRKMMQLILLVLLFHWMEFDVQMSIFIAICTLVGSDLIVLLYLFHMFVLQMRTLKKKEQAPMGGKEIRRSLLSVSLPTTGMRVFHAVTNAIEPFFIKWVLLKSGMTEGMANEHFGLVAGVAFTIGFFPAFIAHSLSTVLIPTVSEAYAKRDGIKLQKLLQQVMMMTFLYGLPAVIVIQVFSVPLTTLFSHSAAAAVYVRLLWPYFLFHYFVIPMQAFLIGLGLVRDALAHFIWSTMVTYCLIYYLGSNPQYQMAGVIIAMNTGTLLIMMMHYLTICKKIEISLILRKSMKHTF
>NZ_CP010525.1|WP_172653436.1|2824628_2825423_+|AAC(3)-family-N-acetyltransferase
MLVTKERLVTDFRKLGLKEGMVVIVHSSLSALGWVCGGEVAVILALMEVVTERGTIVMPAQTANNTDPAFWENPPVPEAWWEEIRRSMPAFDPAVTPTYGMGRVAELFRTFPEVLRSHHPTCSFTAWGRDAKSILSGHSLDFPFGEKSPLARIYDRDGCILLLGVDYQVNTSMHLGESRSKHTKRCTQSCAMTINGKRVWQSYEDYEENSDLFNKIGRAFERSHQVKTGFIGAAPSRLIQQRALVDFTAQYLDELYTDTEKAHH
>NZ_CP010525.1|WP_043052586.1|2825869_2826769_-|SDR-family-oxidoreductase
MYFSRTEPGYRNHPQKYAFPPQHQPEQPGIEKLMHPRPLIEDPSYKGSGKLENKVAIVTGGDSGIGAATAIAFAKEGADVVIPYYSNYEIEDAVRTKRRIEALGQRCLLIPGDLKDPEHCQNVVKQTVDTFGHLDVLVNNHAMQFVQKDLLNITNEQWDFTFKNNIHSFFYLVKAALPYLKAGSSIIFTSSVTAYEGNQNLIDYSATKGAIVAFTRALSQNLVRKGIRVNAVAPGPIWTPLIPASFYPEQVAKFGRDVPMKRAGQPYELAPTYVYLASRDSSYVTGQVLHVNGGTITGS
>NZ_CP010525.1|WP_035182336.1|2826856_2828515_-|acyl-CoA-dehydrogenase-family-protein
MNFYHDDPNLARLLKQYLDPLFFDWAEKELAEFGEMCAGEIDERATHTDREGQPKLIKYNRYGEDVSRVCVNEGYLKTVEQVYNKGIVGYVHKSIPALGQKGNYVYAFAQGYLLSQSEPGFYCPVTLTAAAAYLLDHYGSHELKQAYLPQLISTGEAERYEGATFLTERQGGSDVGANETKAVSEGGCYRLYGEKYFASNVGMCGVAMVLARREGAPSGTKGLSLFLVPWEKENGEKNGIYIRRLKDKLGVCAVPSGEVVFDGAKAYLVGDPRKGFYYMMEALNLSRICNAIASIGIMRRAYREARAYALRRTAFGSRLADYPMVKETLVKMAAKQEVETSAVFRLATLFDRTASGKADEQENIMTRLLIAILKMETAEQAIHFAHEAIEMHGGNGYIEDFVTPRLLRDAQVLTVWEGTANILGLEVLRLMRKFKVHDIFIGMMREKIDQLQAGTWLSAGLDQLEETCRFVMETKEEAAQTYHCKKVARQMVKIYESVTALEDALAGQRQKWIAEAYLRLAWHDPLAIDPELALVKHFEEIVMEKVPANEGN
>NZ_CP010525.1|WP_035182338.1|2828498_2830022_-|long-chain-fatty-acid--CoA-ligase
MNISELLARNARKYPQQEALVSPRERLNYQELNVRVNRLAHALQNCNFKQGDRAVIVMPNTNAFVIAYFAVMRLGGIVVPVNAKSSRAELEYMLDDSGANVLFVHELLFEELKEATFPPHLVKIKTGERVTGCQIFEEMINHSPETEIRCRLKEDDDASILYTSGTTGKPKGVLFTNRNILSAAWMMCVEMAMKPESRILHMMPLSHSAPLHLFLVAGTVVGATHVLSPVFTPEALVETVEKERITHFFGAPVAYLFTAKLPNLQDYDLSTMKYWVYGGAPLSRPEVGLIQNAFRSDRLVCVYGLTEAGPNGTLLLPEEHAEKAGSIGKRAALGMEIRLVNEKGEDVAAGEVGEIALYGESVMKGYFRKPEETNRVFQNGWLLTGDMARKDEEGYYWVVDRKKDMILSGGVNVYPKEIEDVLVTHPKIREVSVIGVPHPEWGETVKAFLVLAEPMDNIEEECKRFLKGKLASYKIPKLYERIEELPRNATGKIQKQVLRGKANELLP
>NZ_CP010525.1|WP_035182340.1|2830018_2830405_-|MerR-family-DNA-binding-transcriptional-regulator
MTCKISELAAEFGVSTRTIRYYEELGLFKPKRSQNGRRCYSKKDYTRLKLIFRGKQLDFSLDEIKEMIELFDCDRSGIKQLKKTIEYGKQKRREVAQQIQNLQELQSELEKYLAEFETRLKRLKEEQG
>NZ_CP010525.1|WP_014095981.1|2831470_2832052_+|biotin-transporter-BioY
MAAKKFRAIDLCYAGMFAALMAIGANITSIAPFLVIGGVPITLQTFFAVLAGLVLGSRLGAISMVAYMLIGLLGAPVFAQFSGGFQTVLSPTFGFILSFIPAAWATGKIVEKRQNLTTYFIAAIIGLILNYLIGTNWMYAAYKIWAQAPQAFSYKIAWVWMAVPLPKDIILSLVAGWLAHRIKAVSPLIALKR
>NZ_CP010525.1|WP_014095982.1|2832132_2832309_-|hypothetical-protein
MHLERSRRFNAVNGEMPCSGILSHPKNAPFQAAAAGSDLIVKRGSEVCIWKDPVVLTQ

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Crispr_ID: NZ_CP010525_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_14

2899910-2899990

Orphan

Consensus_repeat	Method
AAACCCGGACTTGCAAGCACGCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_14

>merge|NZ_CP010525|14|2899910-2899990|CRISPRCasFinder
AAACCCGGACTTGCAAGCACGCCAACTGGTGATGCAGGTACATTCGAAGGAAAGGTGAAACCCGGACTTGCAAGCACGCCA

>NZ_CP010525|14|14|2899910-2899990|CRISPRCasFinder
AAACCCGGACTTGCAAGCACGCCA	ACTGGTGATGCAGGTACATTCGAAGGAAAGGTG
AAACCCGGACTTGCAAGCACGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_014096042.1\|2901070_2901385_-\|iron-sulfur-cluster-biosynthesis-family-protein	unknown	unknown	gnl\|CDD\|366687
NZ_CP010525.1\|WP_017552234.1\|2894641_2895454_-\|teichoic-acids-export-ABC-transporter-ATP-binding-subunit-TagH	unknown	unknown	gnl\|CDD\|184131
NZ_CP010525.1\|WP_026685029.1\|2904902_2906117_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP010525.1\|WP_035182400.1\|2900067_2901054_-\|acryloyl-CoA-reductase	unknown	unknown	gnl\|CDD\|176249
NZ_CP010525.1\|WP_035182393.1\|2896263_2896758_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375438
NZ_CP010525.1\|WP_035182385.1\|2890671_2892621_+\|cytochrome-aa3-quinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|131928
NZ_CP010525.1\|WP_029141973.1\|2893225_2893510_+\|cytochrome-aa3-quinol-oxidase-subunit-IV	unknown	unknown	gnl\|CDD\|200218
NZ_CP010525.1\|WP_035182391.1\|2895521_2896007_-\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|227939
NZ_CP010525.1\|WP_014096043.1\|2901561_2902287_-\|WecB/TagA/CpsF-family-glycosyltransferase	unknown	unknown	gnl\|CDD\|224833
NZ_CP010525.1\|WP_035182404.1\|2903472_2904717_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270453
NZ_CP010525.1\|WP_026104684.1\|2910871_2911987_-\|methionine-biosynthesis-PLP-dependent-protein	unknown	unknown	gnl\|CDD\|181320
NZ_CP010525.1\|WP_026685042.1\|2888714_2889374_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319859
NZ_CP010525.1\|WP_035182396.1\|2897103_2898846_-\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NZ_CP010525.1\|WP_035182402.1\|2902610_2903357_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|274977
NZ_CP010525.1\|WP_017552247.1\|2909699_2910875_-\|cystathionine-beta-lyase	unknown	unknown	gnl\|CDD\|236146
NZ_CP010525.1\|WP_035182408.1\|2907165_2909460_+\|glycoside-hydrolase-family-65-protein	unknown	unknown	gnl\|CDD\|224471
NZ_CP010525.1\|WP_017553873.1\|2892617_2893226_+\|cytochrome-aa3-quinol-oxidase-subunit-III	unknown	unknown	gnl\|CDD\|239214
NZ_CP010525.1\|WP_035182387.1\|2893688_2894432_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP010525.1\|WP_014096031.1\|2889720_2890647_+\|cytochrome-aa3-quinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|273621
NZ_CP010525.1\|WP_035182407.1\|2906129_2906957_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_014096042.1\|2901070_2901385_-\|iron-sulfur-cluster-biosynthesis-family-protein	gnl\|CDD\|366687	pfam01521, Fe-S_biosyn, Iron-sulphur cluster biosynthesis. This family is involved in iron-sulphur cluster biosynthesis. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins.	2.35476e-06
NZ_CP010525.1\|WP_017552234.1\|2894641_2895454_-\|teichoic-acids-export-ABC-transporter-ATP-binding-subunit-TagH	gnl\|CDD\|184131	PRK13546, PRK13546, teichoic acids export ABC transporter ATP-binding subunit TagH.	3.23823e-128
NZ_CP010525.1\|WP_026685029.1\|2904902_2906117_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.90628e-89
NZ_CP010525.1\|WP_035182400.1\|2900067_2901054_-\|acryloyl-CoA-reductase	gnl\|CDD\|176249	cd08289, MDR_yhfp_like, Yhfp putative quinone oxidoreductases. yhfp putative quinone oxidoreductases (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.36849e-174
NZ_CP010525.1\|WP_035182393.1\|2896263_2896758_-\|hypothetical-protein	gnl\|CDD\|375438	pfam17936, Big_6, Bacterial Ig domain. This domain is found in a wide variety of extracellular bacterial proteins often in multiple tandem copies.	1.32549e-09
NZ_CP010525.1\|WP_035182385.1\|2890671_2892621_+\|cytochrome-aa3-quinol-oxidase-subunit-I	gnl\|CDD\|131928	TIGR02882, cytochrome_aa3_quinol_oxidase_subunit_I, cytochrome aa3 quinol oxidase, subunit I. This family (QoxB) encodes subunit I of the aa3-type quinone oxidase, one of several bacterial terminal oxidases. This complex couples oxidation of reduced quinones with the reduction of molecular oxygen to water and the pumping of protons to form a proton gradient utilized for ATP production. aa3-type oxidases contain two heme a cofactors as well as copper atoms in the active site. [Energy metabolism, Electron transport].	0
NZ_CP010525.1\|WP_029141973.1\|2893225_2893510_+\|cytochrome-aa3-quinol-oxidase-subunit-IV	gnl\|CDD\|200218	TIGR02901, cytochrome_aa3_quinol_oxidase_subunit_IV, cytochrome aa3 quinol oxidase, subunit IV. This family (QoxD) encodes subunit IV of the aa3-type quinone oxidase, one of several bacterial terminal oxidases. This complex couples oxidation of reduced quinones with the reduction of molecular oxygen to water and the pumping of protons to form a proton gradient utilized for ATP production. aa3-type oxidases contain two heme a cofactors as well as copper atoms in the active site. [Energy metabolism, Electron transport].	2.13954e-26
NZ_CP010525.1\|WP_035182391.1\|2895521_2896007_-\|VanZ-family-protein	gnl\|CDD\|227939	COG5652, COG5652, Predicted integral membrane protein [Function unknown].	1.18136e-09
NZ_CP010525.1\|WP_014096043.1\|2901561_2902287_-\|WecB/TagA/CpsF-family-glycosyltransferase	gnl\|CDD\|224833	COG1922, WecG, Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane].	1.52389e-79
NZ_CP010525.1\|WP_035182404.1\|2903472_2904717_+\|extracellular-solute-binding-protein	gnl\|CDD\|270453	cd14750, PBP2_TMBP, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose; possesses type 2 periplasmic binding fold. This group represents the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	8.21697e-91
NZ_CP010525.1\|WP_026104684.1\|2910871_2911987_-\|methionine-biosynthesis-PLP-dependent-protein	gnl\|CDD\|181320	PRK08247, PRK08247, methionine biosynthesis PLP-dependent protein.	0
NZ_CP010525.1\|WP_026685042.1\|2888714_2889374_-\|HAD-family-hydrolase	gnl\|CDD\|319859	cd16423, HAD_BPGM-like, uncharacterized subfamily of beta-phosphoglucomutase-like family, similar to uncharacterized Bacillus subtilis YhcW. This subfamily includes the uncharacterized Bacillus subtilis YhcW. It belongs to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), Saccharomyces cerevisiae phosphatases GPP1 and GPP2 that dephosphorylate DL-glycerol-3-phosphate and DOG1 and DOG2 that dephosphorylate 2-deoxyglucose-6-phosphate, and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.29268e-63
NZ_CP010525.1\|WP_035182396.1\|2897103_2898846_-\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_CP010525.1\|WP_035182402.1\|2902610_2903357_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|274977	TIGR04094, AraC_family_transcriptional_regulator, YSIRK-targeted surface antigen transcriptional regulator. Bacteria whose genomes encode only one protein with the YSIRK variant form of signal peptide (TIGR01168) were examined for conserved genes near that one tagged protein. This protein is found adjacent to at various classes of repetitive or low-complexity YSIRK proteins (whether unique in genome or not), in a range of species (Enterococcus faecalis X98, Ruminococcus torques, Coprobacillus sp. D7, Lysinibacillus fusiformis ZC1, Streptococcus equi subsp. equi 4047, etc). The affliated YSIRK proteins include Streptococcal protective antigen (see ) and proteins with the Rib/alpha/Esp surface antigen repeat (see TIGR02331). The last quarter of this protein has an AraC family helix-turn-helix (HTH)transcriptional regulator domain.	2.25778e-31
NZ_CP010525.1\|WP_017552247.1\|2909699_2910875_-\|cystathionine-beta-lyase	gnl\|CDD\|236146	PRK08064, PRK08064, cystathionine beta-lyase MetC.	0
NZ_CP010525.1\|WP_035182408.1\|2907165_2909460_+\|glycoside-hydrolase-family-65-protein	gnl\|CDD\|224471	COG1554, ATH1, Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism].	0
NZ_CP010525.1\|WP_017553873.1\|2892617_2893226_+\|cytochrome-aa3-quinol-oxidase-subunit-III	gnl\|CDD\|239214	cd02863, Ubiquinol_oxidase_III, Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. Ubiquinol oxidases feature four subunits in contrast to the 13 subunit bovine cytochrome c oxidase (CcO). Subunits I, II, and III of bovine CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunits I, II and III of ubiquinol oxidase are homologous to the corresponding subunits in bovine CcO. Although not required for catalytic activity, subunit III appears to be involved in assembly of the multimer complex.	2.57826e-83
NZ_CP010525.1\|WP_035182387.1\|2893688_2894432_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.52776e-80
NZ_CP010525.1\|WP_014096031.1\|2889720_2890647_+\|cytochrome-aa3-quinol-oxidase-subunit-II	gnl\|CDD\|273621	TIGR01432, AA3-600_quinol_oxidase_subunit_II, cytochrome aa3 quinol oxidase, subunit II. This enzyme catalyzes the oxidation of quinol with the concomitant reduction of molecular oxygen to water. This acts as the terminal electron acceptor in the respiratory chain. This subunit contains two transmembrane helices and a large external domain responsible for the binding and oxidation of quinol. QuoX is (presently) only found in gram positive bacteria of the Bacillus/Staphylococcus group. Like CyoA, the ubiquinol oxidase found in proteobacteria, the residues responsible for the ligation of Cu(a) and cytochrome c (found in the related cyt. c oxidases) are absent. Unlike CyoA, QoxA is in complex with a subunit I which contains cytochromes a similar to the cyt. c oxidases (as opposed to cytochromes b). [Energy metabolism, Electron transport].	1.41658e-98
NZ_CP010525.1\|WP_035182407.1\|2906129_2906957_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	6.01745e-79

>NZ_CP010525.1|WP_035182396.1|2897103_2898846_-|phospho-sugar-mutase
MSTDWKTSYEKWNRFAELDAALKAELSGVSGDEKNLEDRFYKNLEFGTGGMRGELGAGTNRMNIYTVRKASEGLANFILDQGEEAINRGVAIAYDSRRKSPEFALETAKTLGKHGIKAYLFDSLHPTPLLSFAVRYLNAYAGVVITASHNPKEYNGYKVYGPDGGQMPPKEADELTGYVNRVENELLVEVGEEKDLIEKGLLVYIGENVDKAYQDQLIKLRQNKEVISSVADSFKIVYTPLHGTGNLPVRRGLENFGFQNVTVVKEQELPDSEFSTVKSPNPEEHAAFELAIRYGEEIGADILLGTDPDTDRLGVAVKNHEGKYEVLTGNQTGALLLHYLLTQKQKQGTLPENGIVIKTIVTSEIGRDIARSFGIPTIDTLTGFKFIGEKIKEFEKTGAHTFLFGYEESYGYLIGDFVRDKDAVQSAVLAAEVAAYYKSMGKTLYEGLLDIFEQYGYYKESLTSLTLKGKEGSEKIAGILANFRAHPLTEVAGIPVSAREDYQSQVRTNAKTGETSKIELPKSNVLKFFLEDGSWFCMRPSGTEPKVKFYFGVKAGSLAESEQRNKRLSDEVMNLVNRML
>NZ_CP010525.1|WP_035182393.1|2896263_2896758_-|hypothetical-protein
MIQQSPANRSGLRTVTNFSKKVTGTAEPYAKITVKASKTTIGTGKAGKNGEFAAKIQPQSIGRKLYVYATDAARHTGKAAATTVKPPAPSAQGVKAGATKVTGTALSGSKVYVKTGKTAIGHAVAGKNGRFTVKIKKQKAGAKLSLYAVKNGIWSDAKTITVQK
>NZ_CP010525.1|WP_035182391.1|2895521_2896007_-|VanZ-family-protein
MKKKQSALVLAGLCILFMAAMFLFSNQPYKEQDMRPELEKLVHLDANTLPKIEFYYGGALVTSTLPYDFIEFWIRKSCHVAEYAVCTLLILLTLRTVLVPVRFAVPAGFLASFLYANLDEWHQSFVSGRTGHFIDVITFDSFGIMIGVCLFLWFTRRKKSR
>NZ_CP010525.1|WP_017552234.1|2894641_2895454_-|teichoic-acids-export-ABC-transporter-ATP-binding-subunit-TagH
MSISVRFKNVSKKYKMYRSNSEKILDIILPGGYGDDFYALQNISFEASNGDVIGVIGVNGAGKSTLSNLITGIIPPTTGTIELNGETSLIAINSGLNNELSGLENIELKCLMLGFTKKQIKELTPQIIEFADIGQFIDQPVKKYSSGMKSRLGFAISVNVDPDILVIDEALSVGDQTFADKCFEKMNEFKDAGKTIFFISHSMGQVKKFCEKAMWLEAGEIKQYGAIDDVLPNYEKFLKEFKSWPKDKQKNFKQMILEKRSKERKEKVAE
>NZ_CP010525.1|WP_035182387.1|2893688_2894432_-|SDR-family-oxidoreductase
MASLENKIAIVTGGASGIGLATAKAFTEKGAKVVISDYNEESGKAVEKELKEKGADVCFIRADASDEQSVADLIAETVNRYGRVDIMVNNAGIGVMATTHELSFEDYQKVISVNQNGVFFGSKYAIREMLKTGGGCIVNTSSILGYVGEPGAFAYNASKGAVNLMTKSLALEYASKGIRVNAVNPGYVETGMVNKEALGDFYDGLVARHPIGRLGRADEIAHAIVFLSENQFVTGIALLVDGGYTAQ
>NZ_CP010525.1|WP_029141973.1|2893225_2893510_+|cytochrome-aa3-quinol-oxidase-subunit-IV
MEHHSKYPIGHVIGFLLSIVLTLVALYVALYTNLSKTAIIWTIGLFAFLQAGVQLFMFMHVKEGENGKINVSNMIYSIIIAIVVVYGTIWVMHF
>NZ_CP010525.1|WP_017553873.1|2892617_2893226_+|cytochrome-aa3-quinol-oxidase-subunit-III
MSDEHLDTSLPLEYQRNQDRLTIFGFWVFLAAEITLFATLFATYFTLQHQTAGGPVQQDIFELKGVLIETFVLLTSSFTCGIAVFNMRNRNKGAMLGWFIVTLLLGLTFVGFEINEFVTYVHDGATLPTSAFLSAFYVLLGTHGCHVSLGILWGISIIIQLIRRGLTPMTARKFFVVSIYWHFLDVVWIFIFTFVYLGGLMK
>NZ_CP010525.1|WP_035182385.1|2890671_2892621_+|cytochrome-aa3-quinol-oxidase-subunit-I
MKLSDFFVTGEPAIYAAEVGMALGAAAVIFSLTYFKKWKWLWKEWLTTVDHKKIGIMYIIVAVLMLFRGGVDALMMRTQLALPNQHLLDANHYDGIFTTHGVVMILFMAMPFLFGLINVAVPLQIGARDVAFPLLNAFSFWAMVAGMCLFNISFIIGGSPTAGWTNYFPLAGTEFTKGVGNNYYALGLQLSGIGTLATAVNFIVTILKMRAPGMTLMKMPMFVWSTLITFIIVLFAFPVLTVALAEVTFDRTFGAHFFTMGSGGSPMLWANLFWIWGHPEVYIVLLPSLGIYADIIATFSGKRLFGYASMVVAMAGIAFFSYFTWVHHFFTMGNTAVVNSFFSISTMIIAIPTGVKLFNEIFTLHKGKIRTTTPMLWSLAFIPTFLIGGVTGVMLSMAAADYQYHNSYFLIAHFHYTLIPAVAYACFAGLHYWYPKMFGYMLNEKLGKITFWLWMVGFNLCFLPQFFVGLDGMARRMYTYEAGLGWTGWNFASTVGAYIMGIGFLVLAWNIVYSIKHGVRDTTGDPWDGRTLDWATPTPVPEYNFAKQPVVSTLDAFAEYKENGTPIYRDEEYKPIHMPNNSAMPFFSAVSMGLAGFGLVWSWWWLAILGGLMMLGCLAWRSFDPDKGHYISVEEIIRTENTRAGGVKR
>NZ_CP010525.1|WP_014096031.1|2889720_2890647_+|cytochrome-aa3-quinol-oxidase-subunit-II
MLRKLPWKLVLLLSLTSLFLLGGCDTKIAVLDPQGPMAREQYHLIVYSSILMAFVFVVVLGLYLYMVIKYRASRLPADYKPPQIHGHKVLETVWTAIPVLLIIAIAIPTVKANYSVEETPKSMKNEKPLTVYVTSSEWKWIFSYPEQGIETVNYVNIPAGRPINFELTSSGTMASFWIPELGGQKYTMPNMTMRLILAADHPGEYTGRNANFNGEGFAKMDFDVLAQTPKDFNAWVKEVKSRAPQMKKSDYEKLIKKEGLVGRQTYTGTHLKWDKPDEQKSYYEESEKGEKQNHHHHHDMSGMDMSGK
>NZ_CP010525.1|WP_026685042.1|2888714_2889374_-|HAD-family-hydrolase
MIKAVIFDFDGLIMDTESEHYDVLCEIFRGYDCEMPLELWGKGIGTHSGFKPFKYLEEQIKKPLDTEKLDHKLEEMFLKRLEKGAAREGVEDYLKSARQLGLKVGLASSSDRKWLHRYLRQLGLLAYFDCIKSSDDVEKVKPDPALYLKAAGCLGVEPEQCLVFEDSPNGSLAAKRAGMACVVVPNRVTKDLKFGEIDHRLGSMAETPLEEVIRFIESR
>NZ_CP010525.1|WP_035182400.1|2900067_2901054_-|acryloyl-CoA-reductase
MKETFRALVMENASQPVLSVQEWDTGRLPDAEVTVKVAYSSVNYKDALVGVKGDFVKSYPFIPGIDLAGTVLASADSRFKEGDEVIVTSYKLGTGHFGGFSEMARVPAAWVVPLPKGLTLRESMILGTAGFTAALSVQKLEDHGLKPGQGPVLVAGASGGVGSVAVDILAKRGYEVTVSTGKKEAHAYLKRLGAARILDREAVTDHEDQSIRKKEWAAAVDPVGGKTTQYIISTLQYGGAVATSGLTGGREVTTTVTPFLGRAISWLGIDSVFCPMDLRVKIWEKLASDFKPEHLTSEIVREISLEQVPAALSDILEGKLQGRTIIKL
>NZ_CP010525.1|WP_014096042.1|2901070_2901385_-|iron-sulfur-cluster-biosynthesis-family-protein
MEIDIKPAALSQFKQIEFQEGEGIRIEAVFVGSCTIAAEHSLKIDHKREDDDLFNVYGIPLLVSKASQKQLGEKVIIDYNPNKGYKLSSDQEVYQYNLDLTRAE
>NZ_CP010525.1|WP_014096043.1|2901561_2902287_-|WecB/TagA/CpsF-family-glycosyltransferase
MKKAFGNIDLTVITEEQFLDEFESRVHEGIKTNVFFLNAHCYNIAQTDRDYYRIINEADYLLNDGVGIEIGAKLFDIPLAGNLNGTDLTPKILKRCEKNGFSVFVLGATETNLQSAIQHFRKDYPDLKIAGCHHGYFQSKHEIVAMINRSHADVLLVGMGVPLQEKFIAGFDQELSCTARLGVGAFIDFASGNVPRAPYLFRKLRIEWLFRLLREPKRLWKRNFGSLIFLCRILRYKWKHS
>NZ_CP010525.1|WP_035182402.1|2902610_2903357_-|AraC-family-transcriptional-regulator
MKQSAISKSIIERYLSYRVEHQREYFLHPPYMMEKQLLNAVKEGRVEAAESVLKTINTLERAKLAEEPIRSLRNSLICICTLFTRAAIEAGVPPETAFNISDAHILEIERIKTQEKLFELEYSMLRNFTEAVQQARKQEHRYSHAIHMAVAYIHENILQVITLESLAKHVYLNPSYLSHLFKKETGVSVTDYINKKRIEESIYFLLHTNITISEIALLFHFCNQSYYTLLFKKYMGLTPKEFREQNQH
>NZ_CP010525.1|WP_035182404.1|2903472_2904717_+|extracellular-solute-binding-protein
MWKKAGVILAALTLVIGVLAGCGSNSNSKSSKSGSSSKKIVLKFAAQNDSTPATKAVIAAFNKQSKKYQVKWVQMTNDSAQMHDQLLTSLSSGSSEYDIMSMDVVWGGEFAGAGYLVPIDKKMMDANLTKDQFNAGSMASGNYEGKQYTLPFFPDLGILYYRSDIVSKEDAAKLESGDYTYKELGDMAAKYAGKNGTTNGFVYQSKQYEGLTVNVTEFTNHYKDIKGGLETMYQFTKAAWAPKDLLNYMEQQTLDSFAQGKSVFARNWPYQYGTIKTGGEGVKVDIKNVGIAPLPNGGAVGGWLLGINKNSKHVEGAWEFVKFVAGKKGQKIMSTKGGYLPGYNDLLNDPDVQKQNKMLTMPGFQKALKTTIARPVSAKYSKVSDTIQIAAHKYLSTGQNLDDAVKTIQDATGK
>NZ_CP010525.1|WP_026685029.1|2904902_2906117_+|sugar-ABC-transporter-permease
MKKNRLQAFLFILPALLFIGVFSLWPIFQSLRYTFFDYQLNNQQKSGLYMSPRYNFDLFDETQTYVRLFLTEDREKITDPADRQKVDKLVHRVADVAKQYKGRKGVQKISQADQKKLMGLYTDSSKLVKEINAKYNTQNGKNLSKIVKDFKSSFVPSNFIGFKSYKEALHDKRLGHALWNTVLFTVVSVFLEFVLGLGLAMIMNKAFRGQGIVRTTSLIPWAIPTAVAALMWSYLYDGTSGVVAHFFQSIGLISDSRILLLTGSGAMVSTILADVWKTTPYMALLLLAGLQNISKGLYEAASIDGATKIQQFFKITLPMLKPSILVALLFRTLDAFRVFDLIYVLTGGGPGGATETMSVYGYKTMFGQTNFGYGSVIVIIMFICVAIIATIYIKVLGANLMDKN
>NZ_CP010525.1|WP_035182407.1|2906129_2906957_+|carbohydrate-ABC-transporter-permease
MKTNRKWNVLIIALIAVFLFGMIFPFFWIFITSFKPSGEIFGNGAFRVFAHHPTWENYTQIFQKGILTSVKNSFIVATTTTVYIILIATFTAYAISRFDFKGKNLLLGLILAVSMFPQMIVTGPIYNLFLHLHLTNSYAIVLPYSTITLPTAVWILVTHFNQIPLALEESAKIDGATPVQTLFRIVFPLAAPGVFTTAIITFIAAWNEFLLTITLNSDANYHTVPVAISFLRTQFEILWGQVAAATTVVTVPTLIIVLLFQKQIVSGLTTGGVKE
>NZ_CP010525.1|WP_035182408.1|2907165_2909460_+|glycoside-hydrolase-family-65-protein
MTWEITKHELDKQMLLVNESLFALGNGYLGVRGNFEEGYPEEIPSIRGTYLNAFYDITEIQYGEKAYGFPETGQKMLNVIDAQTIEIFLGEEKERFSLFEGEVLGFSQTLHMKRGFSERAIHWKSPSGKEIKLTFSRLVSFTQRELFAIQVKMEPVNFSGPVRVISTVNGDVQNYVDKNDPRTGSAHAKKLAVTKVAEDRGTIVLRVRTFASGLEMACAATHAVSVSCECHYEQDEQKVHAIIDFKHGEPVSLTKFAIYTDTLRHGDHIAEKAAAILKSMQGKDFSALLREQEQYLATYWQAADIEIDGDPKLQEGIRFNLYQLLQSVGKDTASNIAAKGLSGEGYEGHYFWDTEIYIFPVFLLIHPELARHLLLYRYHILDHARARAKEMGHQKGALFPWRTISGTECSPYFPAGTAQYHISADIAYSYMQYWYATQDQDFMKQYGVEILVETARLWLEVGHYREKDGKFAIEDVTGPDEYTAIVNNNYYTNVMAKYNLKSAHKFYHWLKETDDAYFAAFAARLGLTDEEAASWLKAADAMYLPYDEKRGIHKQDDSFLDKAVWDFEHTPKDHYPLLLHYHPLTIYRYQVCKQADTVLAHFLLEDEANPETIRNSYHYYEKVTTHDSSLSTCIFSIMASRLGEAEKAYHYFIETARLDLDNTHGNTKDGLHMANMGGTWLSIVYGFGGVRIKENGFFLNPTIPEQWDRYLFRLTYQNRKFQVEVARHAFKVTLLEGDALDIHIGGRTETLKPGRTVTRPISGL
>NZ_CP010525.1|WP_017552247.1|2909699_2910875_-|cystathionine-beta-lyase
MTNEDYSFQTRLLHNSHKIDPATGAVSVPIQHASTYHQADIDQFGKYDYSRSLNPTREALEDVIAELEGGVKGFAFASGMAAISTAFLLLSAGDHVVITEDVYGGTFRMVTEVLTRLGIEHTFVDMTNLEEVRQAVRPNTKAFYVETPSNPLLKVTDIRAVSELAKETGALTFVDNTFLTPALQRPLELGADIVLHSATKFLAGHSDVVAGLAVVKDEALAARLGFLQNSFGAVLGVQDAWLVLRGLKTLHVRLLQSQQSAVKIAHFLDAHPLVRNVYYPGLGHHPQHALQKLEAQGPGAVLSFELEDEEALRTFVSHVKIPVFAVSLGAVESILSYPAKMSHAAMPPEDRRKRGISDSLLRLSVGLENPDDLIADFEQAFSYTKAGTTVK
>NZ_CP010525.1|WP_026104684.1|2910871_2911987_-|methionine-biosynthesis-PLP-dependent-protein
MYHTETKLAQIGNRSDRVTGAVNPPVYFSTAYRHEGIGQSTGFDYSRTGNPTRQLLEEAIADLEGGDRGFACSSGMAAIFTVLSLFQAGDEWIVSDDLYGGTYRLLEQGYKKWGLCCKYVNTCNPENIEQEITPKTKAIFLETPTNPLMQQTDIGAVAEIAKRHGILLIVDNTFYTPLLQQPIKEGADIVVHSATKYLGGHNDVLAGLIVAKGAELCEQLFLYHNGAGATLSPFDSWLLMRGMKTLALRMEKHEKNAKAVAAFLSAHPDVKDVLYPGRGGMLSFRVKEESWVDPFLRGLSLITFAESLGGTESFITYPATQTHADIPEEKRIASGVDNCLLRFSVGIENERDLLADIEKAFANIHEGVQTR

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Crispr_ID: NZ_CP010525_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_15

2993956-2994048

Orphan

Consensus_repeat	Method
ATACGGCCCACACCAGAAAAGGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_15

>merge|NZ_CP010525|15|2993956-2994048|CRISPRCasFinder
ATACGGCCCACACCAGAAAAGGAAGGCTGCGGGGCAAGGTCGGCCGCTATATGACTCAAAAACGACAAAAAACGGCCCACACCAGAAAAGGAA

>NZ_CP010525|15|15|2993956-2994048|CRISPRCasFinder
ATACGGCCCACACCAGAAAAGGAA	GGCTGCGGGGCAAGGTCGGCCGCTATATGACTCAAAAACGACAAA
AAACGGCCCACACCAGAAAAGGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_017551904.1\|2999848_3000421_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380348
NZ_CP010525.1\|WP_017551905.1\|2998600_2999416_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|379207
NZ_CP010525.1\|WP_014096115.1\|2982136_2983309_-\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366120
NZ_CP010525.1\|WP_017551911.1\|2980890_2981988_+\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|236489
NZ_CP010525.1\|WP_014096128.1\|3002516_3003077_-\|maltose-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100047
NZ_CP010525.1\|WP_035182470.1\|2988102_2989185_+\|iron-containing-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|341451
NZ_CP010525.1\|WP_043052469.1\|2995410_2996820_-\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209
NZ_CP010525.1\|WP_017552043.1\|2994158_2995343_+\|hydroxymethylglutaryl-CoA-synthase	unknown	unknown	gnl\|CDD\|213655
NZ_CP010525.1\|WP_013858390.1\|3000571_3000865_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_014096130.1\|3003821_3004967_+\|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|130254
NZ_CP010525.1\|WP_035182471.1\|2992327_2993806_+\|carboxylesterase/lipase-family-protein	unknown	unknown	gnl\|CDD\|225181
NZ_CP010525.1\|WP_014096120.1\|2989680_2990655_-\|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl\|CDD\|227751
NZ_CP010525.1\|WP_013858399.1\|2989388_2989553_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_017551910.1\|2984911_2986447_+\|xylulokinase	unknown	unknown	gnl\|CDD\|198374
NZ_CP010525.1\|WP_043052588.1\|3001216_3002254_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235935
NZ_CP010525.1\|WP_014096118.1\|2986436_2987816_+\|sugar-porter-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340917
NZ_CP010525.1\|WP_035182475.1\|2997260_2997977_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293807
NZ_CP010525.1\|WP_014096129.1\|3003091_3003637_-\|GbsR/MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224427
NZ_CP010525.1\|WP_026104657.1\|2983517_2984852_+\|xylose-isomerase	unknown	unknown	gnl\|CDD\|235487
NZ_CP010525.1\|WP_014096121.1\|2990599_2992177_-\|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl\|CDD\|223679

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_017551905.1\|2998600_2999416_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|379207	pfam13472, Lipase_GDSL_2, GDSL-like Lipase/Acylhydrolase family. This family of presumed lipases and related enzymes are similar to pfam00657.	5.51174e-18
NZ_CP010525.1\|WP_014096115.1\|2982136_2983309_-\|ROK-family-transcriptional-regulator	gnl\|CDD\|366120	pfam00480, ROK, ROK family.	3.349e-71
NZ_CP010525.1\|WP_017551911.1\|2980890_2981988_+\|quinolinate-synthase-NadA	gnl\|CDD\|236489	PRK09375, PRK09375, quinolinate synthase NadA.	3.71819e-153
NZ_CP010525.1\|WP_014096128.1\|3002516_3003077_-\|maltose-O-acetyltransferase	gnl\|CDD\|100047	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).	1.20276e-101
NZ_CP010525.1\|WP_035182470.1\|2988102_2989185_+\|iron-containing-alcohol-dehydrogenase-family-protein	gnl\|CDD\|341451	cd08172, GlyDH-like, Glycerol_dehydrogenase-like. This family contains glycerol dehydrogenase (GlyDH)-like proteins that have yet to be characterized, but show sequence homology with glycerol dehydrogenase. Glycerol dehydrogenases (GlyDH) is a key enzyme in the glycerol dissimilation pathway. In anaerobic conditions, many microorganisms utilize glycerol as a source of carbon through coupled oxidative and reductive pathways. One of the pathways involves the oxidation of glycerol to dihydroxyacetone with the reduction of NAD+ to NADH catalyzed by glycerol dehydrogenases. Dihydroxyacetone is then phosphorylated by dihydroxyacetone kinase and enters the glycolytic pathway for further degradation. The activity of GlyDH is zinc-dependent; the zinc ion plays a role in stabilizing an alkoxide intermediate at the active site.	0
NZ_CP010525.1\|WP_043052469.1\|2995410_2996820_-\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	1.22253e-169
NZ_CP010525.1\|WP_017552043.1\|2994158_2995343_+\|hydroxymethylglutaryl-CoA-synthase	gnl\|CDD\|213655	TIGR01835, 3-hydroxy-3-methylglutaryl_CoA_synthase, 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade. This clade of hydroxymethylglutaryl-CoA (HMG-CoA) synthases is found in a limited spectrum of mostly gram-positive bacteria which make isopentenyl pyrophosphate (IPP) via the mevalonate pathway. This pathway is found primarily in eukaryotes and archaea, but the bacterial homologs are distinct, having aparrently diverged after being laterally transferred from an early eukaryote. HMG-CoA synthase is the first step in the pathway and joins acetyl-CoA with acetoacetyl-CoA with the release of one molecule of CoA. The Borellia sequence may have resulted from a separate lateral transfer event.	0
NZ_CP010525.1\|WP_014096130.1\|3003821_3004967_+\|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein	gnl\|CDD\|130254	TIGR01186, Choline_transport_ATP-binding_protein_OpuBA, glycine betaine/L-proline transport ATP binding subunit. This model describes the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. Functionally, this transport system is involved in osmoregulation. Under conditions of stress, the organism recruits these transport system to accumulate glycine betaine and other solutes which offer osmo-protection. It has been demonstrated that glycine betaine uptake is accompanied by symport with sodium ions. The locus has been named variously as proU or opuA. A gene library from L.lactis functionally complements an E.coli proU mutant. The comlementing locus is similar to a opuA locus in B.sutlis. This clarifies the differences in nomenclature. [Transport and binding proteins, Amino acids, peptides and amines].	7.09512e-174
NZ_CP010525.1\|WP_035182471.1\|2992327_2993806_+\|carboxylesterase/lipase-family-protein	gnl\|CDD\|225181	COG2272, PnbA, Carboxylesterase type B [Lipid metabolism].	5.81809e-163
NZ_CP010525.1\|WP_014096120.1\|2989680_2990655_-\|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl\|CDD\|227751	COG5464, COG5464, Uncharacterized conserved protein [Function unknown].	5.53097e-09
NZ_CP010525.1\|WP_014096118.1\|2986436_2987816_+\|sugar-porter-family-MFS-transporter	gnl\|CDD\|340917	cd17359, MFS_XylE_like, D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily. This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.46733e-167
NZ_CP010525.1\|WP_017551910.1\|2984911_2986447_+\|xylulokinase	gnl\|CDD\|198374	cd07808, FGGY_D-XK_EcXK-like, Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases. This subgroup is predominantly composed of bacterial D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17), which catalyze the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. D-xylulose has been used as a source of carbon and energy by a variety of microorganisms. Some uncharacterized sequences are also included in this subgroup. The prototypical member of this CD is Escherichia coli xylulokinase (EcXK), which exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ is required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	0
NZ_CP010525.1\|WP_043052588.1\|3001216_3002254_+\|SDR-family-oxidoreductase	gnl\|CDD\|235935	PRK07109, PRK07109, short chain dehydrogenase; Provisional.	1.27969e-144
NZ_CP010525.1\|WP_017551904.1\|2999848_3000421_+\|cupin-domain-containing-protein	gnl\|CDD\|380348	cd02219, cupin_YjlB-like, Bacillus subtilis YjlB and related proteins, cupin domain. This family includes bacterial and fungal proteins homologous to YjlB, a Bacillus subtilis protein of unknown function with a cupin beta barrel fold. The active site of members of the cupin superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two-domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.	4.67245e-74
NZ_CP010525.1\|WP_035182475.1\|2997260_2997977_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.34643e-74
NZ_CP010525.1\|WP_014096129.1\|3003091_3003637_-\|GbsR/MarR-family-transcriptional-regulator	gnl\|CDD\|224427	COG1510, COG1510, Predicted transcriptional regulators [Transcription].	2.01902e-46
NZ_CP010525.1\|WP_026104657.1\|2983517_2984852_+\|xylose-isomerase	gnl\|CDD\|235487	PRK05474, PRK05474, xylose isomerase; Provisional.	0
NZ_CP010525.1\|WP_014096121.1\|2990599_2992177_-\|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl\|CDD\|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	1.16274e-166

>NZ_CP010525.1|WP_035182471.1|2992327_2993806_+|carboxylesterase/lipase-family-protein
MKTAIVETVFGKARGYEEKGVQIWKGIPYAKPPIGPLRFRPPELPEPWAGVKDCTQFGPIAWQPPVELMDFLGNPAENMDEDCLNLNIWTPGADGERRPVMVWIHGGAFANGAGSAPSYDGSAFAKNGDVVVVTINYRLGALGFLYLGEMGGEKYEASGNCGILDQIAALKWVKENIAAFGGDPDCVTIFGESAGAMSVAALLSSPAASGLFHKAILESGAANFTATPERAAKNTRRILETLGLEKKDVAKLAEVPAKNLAEAVNSLPFMSLLPVTDGIVLPEHPERALENAAKDIPVLIGTNKDEYRLFTVFDPVWKRQDPKEMQDVFQKTFAKYWDALSAKITDPSAFTQELYDRIMTYFVFTGPALKLADTRAQTGEKVWMYQFDWESPVYNGTLKACHALEIPFVWHTLEQPGTENLTGNAPGRHALADRMHQAWIAFAQNGDPNCSLLPEWPPYNTRQRPAMIFGQDCRVEKDPHQAERALWGGLGE
>NZ_CP010525.1|WP_014096121.1|2990599_2992177_-|YifB-family-Mg-chelatase-like-AAA-ATPase
MATIISSIGLKGIEGYCVHAEVQMMLGCGSGITIVGLPDASVKESKERIRGACSSIGCMLFQSKTIVNLSPADERKNSPALDLPIAIGLMAENHFFHARIPDHTAFLGALSLDGSVQAVAGMLPYVMAARGLGMKRLYLPASAELPFSQMDGMDIIFVQHLKDVLDSLSGKKLPPVRKKRQLQPDEYSFEADFSMILGHRHAKKVLEIAAAGSHNVLMYGPPGSGKSMLAEAFPSILPPLSETSSFEVAGLYQLANVKRGFHRKPPFRAPHHASSAVSLVGGGSRPHPGEISLAHHGVLFLDEMAEFPKRTLDMLRQPLENGKVTISRAASTVTYPARFIMLAAMNLCPCGYLGSPHAYCTCTPKQIQAYQNRISGPLLDRFDIFLPVGTVPLLEESGKINETSEQIRTRVTEARKRQYERYGAEVCNGTVPNEIFLQKNPLANSSSLMLRQWASKENFSSRAQMKILRLARTISDLQGSRELSEDALWQALQMKRNHLFGKRKVDAYATYNGRKSGVFAARPLV
>NZ_CP010525.1|WP_014096120.1|2989680_2990655_-|Rpn-family-recombination-promoting-nuclease/putative-transposase
MQLIMEEKAEYLPHDRLFKELIQTFFADFMEAFFPEVARWMDFSDVEFLQQDLFTDITAGEQRRIDILAKLKLKGEDTVVLIHVEPQSYYQMEFPERMFIYYSRIYEKYRLPVLPIAVFSYNKRRETPSLFTVRIRNFESIRFRYMSIHLIRKNWKEYIRSNNPVAAALLSKMGYTKKEKVQVKVEFLRMMARMELDPARMALIYGFFDSYFKLTDKEDELVMSSIKNLDPQEADQILRLPNSFYDKGYKKGKEEGKEEGKEEGKEEGLKEGLKEGERRAALRIAKRMLEENQDLASIAKYTGLAEEELKKLKQSGATRLRCDQ
>NZ_CP010525.1|WP_013858399.1|2989388_2989553_-|hypothetical-protein
MEKENGRVEPTLATGLDDQEELDQKATPEEIAKGEYTKVVRLSLDEADPSKGED
>NZ_CP010525.1|WP_035182470.1|2988102_2989185_+|iron-containing-alcohol-dehydrogenase-family-protein
MRLSQVIRSGPNQYICEEDAAKYLEEKLKEFKYPVVITGVKSFKAFQKFASIPQNWPVLRYDHTASEKNMAKLAEQAGRADVIVGIGGGKVLDTAKGTAELLNCEVVLVPTLAGTCAGYTPLSAVYHEDGSFSHVAYYKRSAFLTLIDLRILLNAPAEYLLGGIGDSLAKWYEAEGITRSMKHLPVMVELGLRSAKAIYEGILRDSEQALHDRNEGKITDAFRNIVEIIIGAAGTVGGFAGEYGRMAGAHAIHNGLTFLPETHSILHGSKVAYGILVQLAATGDINEVKKLLPLYQKLGFPYNLDTLHVTENHGAAIEKVAAYAAKPEESFRLLGSFTKAQIAKAMETIEQLTAEKADIK
>NZ_CP010525.1|WP_014096118.1|2986436_2987816_+|sugar-porter-family-MFS-transporter
MKFKINNGLIYFFGALGGLLFGYDTGVISGALLFIKNDLHLTSWTEGIVVSSILFGCMIGAAISGAMSDRWGRKKVVLIAASVFCIGALGTALAPNTGVLILFRVILGLAVGSASTLVPMYLSEMAPTSIRGALSSLNQLMIMTGILLAYIINYVFAATGSWRWMLGFALIPGLLMLIGMLFLPESPRWLLKQGKEPEARTILNYMRKGHGVEEEIREIKQANELEKNQGGFSEVKQAWVRPALIAGIGLAVFQQIIGCNTVLYYAPTTFTNVGLGASAAILGTVGIGIVNVIITAIAVLIIDKVGRKPLLLIGNAGMSLALFVLGIVNALLGPSTAASWTTVICLAVYIAFFSLSWGPVVWVMLSEIFPLKIRGIGMGIGSVTNWLANLIVSLTFPKLIEQFGISTMFIIYGIMGVLAFIFVTRKVSETKGKSLEQIEIDLRQQAEHKKFNFSQSIQK
>NZ_CP010525.1|WP_017551910.1|2984911_2986447_+|xylulokinase
MKYAIGVDLGTSSVKVLLVDQNGQVVSSVSKSYPLMQPHPGYSEQDPEQWVEKTIQALKELTEKSGVPRDEIEGLSFSGQMHGLVLLDENLQVIRNAILWNDTRTTEQCKKIDQVLGGKLLEITKNPALEGFTLPKILWVQQYEPENFRKTRVFLLPKDYLRYRLTGTIGMDYSDAAGTLLLDIVNQSWSTDILRTFDIPADICPPLVETEAEVGTLLPDIAATCGLSPATKVFAGGADNACGAIGAGILEEGKALCSIGTSGVFLSYESDSNKNFGGKVHLFNHGQKDAYYTMGVTLAAGYSLSWFKDTFTKGEDFATLLEEAAHSSIGANGLLFTPFIAGERTPYADAKIRGTFTGIDSSHTRRDFTRAVMEGIAFSINESVEIFRNYGKNIDTVISIGGGAKSDLWLQIQADIFQAKVIKLQNEQGPGMGAAMIAASGLGWFSSLKDCAAAFIRTGRTFEPIPKNVKRYRDFYQVYKDVYPHTVAINHQLFDLRRVNESRFGGKTDEI
>NZ_CP010525.1|WP_026104657.1|2983517_2984852_+|xylose-isomerase
MAYFPNVSKITYSGKQLKSGLSFNHYNPKELVGGKTMEEQLRFSVAFWHTFTESGTDPFGAGSKIRPWDRFTGMDLAKARVEAAFEFFEKLGNPYFCFHDRDIAPEGDTLRETNKNLDVIVAMIKDYMKTSKVKLLWNTANMFTNPRFVHGAASSCNADVFAYAAAQVKKGLEVGKELGAENYVFWGGREGYETLLNTDLKLEQDNLARFFHMAVDYAKEIGFDAQFLLEPKPKEPTKHQYDFDAATTIAFLKTYDLDQHFKLNLEANHATLAGHTFEHEIRVARTHGLLGSLDANQGDPLLGWDTDEFPTDLYSTTLAMYEVLKNGGLGRGGLNFDAKTRRASFTDEDLFYAHIAGMDSFALGLKVANRLIEDRVFDAFIEERYSSYKEGIGADIVSGKADFKSLENYILDKKEIINQSGRLEQLKNTLNHYIVQEAYQSVNA
>NZ_CP010525.1|WP_014096115.1|2982136_2983309_-|ROK-family-transcriptional-regulator
MHIADQSFIKNQNQRVILNELMKHEQISRAKLAKITKLNKATISSQVSFLIEKKLVKEVGTGLSSGGRKPVMLVFNEKAGYAIGVDIGVTYILTVLTDLDGNMIYSDYCEIEDPSFEMIKPVIIERIRLVASKVSSSPYGIIGIGAGVHGFVDMQQNVLFTPNSGWRDVDLKGLLQTHFDCPVLVDNEANAGAYGEKLFGILKGCKNGIYVSIGIGIGLGIIVNDELYRGKEGFSGEMGHMSIDFNGRQCGCGNKGCWELYASEKAFYDQLCLVKNKRRITLEEVTNWVKENDGETLRELDKLGYFLGIGLTNIINTFNPEAIVLRSNLIQENPTILNSIQSTIASRVSKYVRQNHRIYLSQLHRNATAVGAAAFIVHHFLMESEELYGN
>NZ_CP010525.1|WP_017551911.1|2980890_2981988_+|quinolinate-synthase-NadA
MSLLKTLQLTALPEKYQSLAQEEMENRVWDIKKEMGAQLFLPCHHYQREEVYQFADAAGDSLQLAQISAKNRHAKYIVFCGVHFMAETADILTSAEQTVILPDMRAGCSMADMADIHQTERAWDMLQSLFGDTMLPLTYVNSTAAIKAFVGRNGGATVTSSNAKKMVKWAFTQKKRVFFLPDQHLGRNTAFDLGVELADMAVWDPIRNELIYEGALENVKVILWKGHCSVHAHFTIKNIEFVRAKYPDMQIIVHPECAHEVVALSDFSGSTKYIIDTIENAPAGSAWAIGTEMNLVQRLIKNHPDKKIISLNPVMCPCLTMNRIDLPHLLWSLENIIEGKETNVIKVEENTARDAVLALERMLKL
>NZ_CP010525.1|WP_017552043.1|2994158_2995343_+|hydroxymethylglutaryl-CoA-synthase
MQIGIDKIGFYTPHLYVDMEKLALARNEDPGKFLIGIGQEKMAVAPVTQDAVTLAANAALEILTDEDKEKIDFVIFGTESGVDHSKAAAIYVHRLLGLKPEVRAVEVKEACFGATAGLQMARGHIALHPESKVLVLGSDISRYGLNTSGEVTQGAGAVAMVVSAHPKILAIEEPSVYHTEDIMDFWRPVYSDSAYVDGKFSNEKYISFFQNVWKQYREKTGFTLSDFKAICFHMPYTKMGLKALRTVLDETDEDGRERLLAHYETSKSYNKIVGNIYTGALYLSLLSLLEQNTNIEAGARIGLYSYGSGAVGEFFSGILQPGYRKALQPARHQQMLEARKEISVAEYEAIFTTSLPNDGSAVTLPVNEDPATVCLAGIEGHKRQYVNKNNRVGG
>NZ_CP010525.1|WP_043052469.1|2995410_2996820_-|group-II-intron-reverse-transcriptase/maturase
MKVTEETNKCRKQEETCCQKDTAEQEGYGRGHSFKRITENNTTNTNRQNEWMLERILSSNNLHRAYKKVKKNKGAGGVDGMKTGELLAYLTEHQRELVLSIRNGTYKPQPVRRVEIPKDNGKTRKLGIPTVVDRVIQQAISQVLVPIYERKFSDNSYGFRPHRSTHQALLKCQKNVNEGYQYVVDLDLEQYFDTVNHSKLIQILSETIHDGRVISLIHKFLNAGVMIKGIRTTNDFGVPQGGPLSPLLANVMLNELDKEMEARNHRFVRYADDVIIFCKSRRSCERTYHNILPFIEKKLRLKVNREKTMITHIRNIKFLSYGFYLYEGKCKFRVHPKGVQKLKEKIRRITGRSNGLSVEERKKRLNDTVRGWVNYYKLADMKSLVTRLDQWTRRRMRMVTWKRWKRVRTRFYWLKKLGINKRKAWEWANTRKGYWRISGSHILARTLTNELFRRARYISFLDYYLSVRS
>NZ_CP010525.1|WP_035182475.1|2997260_2997977_-|MBL-fold-metallo-hydrolase
MKKIAEGVAMLEINLNHFIIHPTLIWDEQKAVLVDAGMPGSLDLIHAEMEKAGVPFEKLDAVILTHQDMDHIGSVPEILAESGHSITVYAHGLDKPYIEGERLLIKADPEKIDPARWESMPEEMKQMYLNPPKAKVDKVIGDGEVLPFGGGIEVIFTPGHTPGHCCLYLKKSKTLIAADAMVADNGKLHGPRQQVTPDMGTAMASLKKLLDFDIESVICYHGGLCHENVNEQIRKLAE
>NZ_CP010525.1|WP_017551905.1|2998600_2999416_-|SGNH/GDSL-hydrolase-family-protein
MGKKGWLVVLLFFITVGVLGTGNWYYQANTGKTIEKAQQQYKKDLAKERQHSLEAKAAKESAAKQIYEKHKGKELVYLPVGSSLTAGDFATKKSKTYTALLAGRIHQDLGYEVKTINGYGKSGTGLKDHGADSLLHIIFNHPDLVTIEFGTFDLNRNAKNTYVSTGQFKKDLENFVDEIRKGTGKKTKIILITTWNSGQLSFTYDHAIEEVGKAKGVPVANIESVWLNRSDTHGPNGEKAATGKSDGWLANDKGHKEIANTVYKKAYGLLK
>NZ_CP010525.1|WP_017551904.1|2999848_3000421_+|cupin-domain-containing-protein
MKRMLPLMAASDGKNAGGTAANDHVSAFYFEENDGIPNNPFLPVLIYHGVFKGRTDEIEKVFQKNNWGNNWVWTIFPYHHFHSNSHEVIAVRSGYAKVQLGGPKGKIFTISEGDCVLLPAGTGHKRIESGGGFAVTGGYPGGQDYDTQMRADETLRENIRKTGMPETDPVFGKNGPLFSYWTREPGGKAG
>NZ_CP010525.1|WP_013858390.1|3000571_3000865_+|hypothetical-protein
MKEILEQVKEKLENAYNHPDSADLDACIRQLQDARQQYGDKGTMIEDAITAIEQAKHSIPEHRHAGTDSAAGAFGQAYNALEHAIESFSGTENNDPF
>NZ_CP010525.1|WP_043052588.1|3001216_3002254_+|SDR-family-oxidoreductase
MDASMEKPLSLKKLADQVIVITGASSGIGLATARMAAARGARLVLAARNEHALKILANELKNNGSSAIWVRADVGREEDVKHIAATAIKTFGGFDTWVNNAGVSIFGEAMDVSIEDMKRMYDTNFWGAVYGTRLAVQHYKSRGVPGAVINIGSLFGDRGTVIQSTYASSKFALHGFTESIRMELEKEHAPVSITLVHPGRIDTPYNEHARSYLKKQPAHYMSMIYPPQAVAEAILFAAEHPKRDMYVGSQAKMVAVLGRFLPRFMDKLMELTMYRTQHSDRPSKSKADSALYHPGYGLHERGTNKGWMRRNSYYVKMSKYPLASAAIAAFVGAALWAAVSPRQKD
>NZ_CP010525.1|WP_014096128.1|3002516_3003077_-|maltose-O-acetyltransferase
MSTEKEKMIAGKLYNAGDRELTQARLKARRLIRTFNETDETDLETRTALLKKLFGSTGEHLFIESDFRCDYGFNIHVGENFYANFDCVILDGGLVEIGKNCMLAPGVHIYTATHPLDAKTRVSGLELTKPVKIGDNVWIGGRAVINPGVTIGNNAVIASGAVVVKDVPDNAVVGGNPAQIIKMVEA
>NZ_CP010525.1|WP_014096129.1|3003091_3003637_-|GbsR/MarR-family-transcriptional-regulator
MEEKTLDKVVRAKEQYIEKIADHIRAFGIPPTVGRVLGIIYINHRPMTLDELSQATGMSKTRMSQVVREMVDMNIAEKVFEKGVRKDLYNVGLDFYDTFVAIFTSNLRKIIHRNKFFEKKFARELAELKDNEELPPEMEKQLNHFLNELFNLAEYYDWLSRLVDFFESGKIFEYVPKKKQE
>NZ_CP010525.1|WP_014096130.1|3003821_3004967_+|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein
MLKFDHVSKIYKGGKRAVDDLNLEFASGRFIVFIGPSGCGKTTTMKMINRLIEPTEGTIYINGKNIKDTDPVKLRREIGYVIQQIGLFPHMTIQQNISLVPRLLKWPEEKQRERAKELLQLVDMPEEFLDRYPHELSGGQQQRIGVLRALAADQPLILMDEPFGALDPITRDSLQDELKKLQKELGKTIVFVTHDMDEAIKLADQIVIMRDGKLVQTGTPDEILREPANEFVETFIGKERLLQARPNIQTVEQIMSPKAVTVTVDKTLTEAIQIMKEQRVDSLLVVDSRKVLLGYIDVEIIDRNRRKPVLVKDVVETNLIAVEKDTLVRDTVRKILKRGIKYVPVVDHEHRLVGIVTRASLVDIVYDSIWGEEEPVSEIIS

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Crispr_ID: NZ_CP010525_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_16

3286677-3287269

Orphan

Consensus_repeat	Method
CCNTTTTGTCTTTTTGAA	CRT

11 spacers

The CRISPR arrays of NZ_CP010525_16

>merge|NZ_CP010525|16|3286677-3287269|CRT
GCCTTTTGTCTTTTTAAAGACCTCTAAAAAACATTGGGACCATCGTACGGATCCTTTTTTGTCTTTTTGAACGTTTTAAAAAGACATTTTGACTCAGTCCCACCCCCGTTTTGTCTTTTTGAAGGCTTCTAAAGGACACTTGGACCACTACCCAGATCCTTTTTGTCTTTTTGAGCATCTTAAAAAGACATTTTGGCTCGATCCCCACTCCTTTTTGTCTTTTTGAAGGCGTCTAGGGGACATCTTGGGGCGAGAATCATTGCCTTTTGTCTTTTTGAAGGTCTCTAAAGGACATTTGGACCTCCGCCCGGATCCTTTTTTGTCTTTTTGAACGTTTTAAAAAGACATTTGGACTCGGTCCCACCTCCTTTTTGTCTTTTTGAAGTGTTCTAGGGGACATTTCAGGGTGGGAATCATTTCCTTTTGTCTTTTAGAAGGCCTCTAAAGGACACTTGGACCACTGCCCAGATCCTTTTTGTCTTTTTAAACGTCTTAAAAAGACATTTGGGGGCGGATCCCATTCCTTTTTGTCTTTTTGACGGCTTCTAGGGGACATTTTGAGCTCTGGCCTGATCCCTTTTTGTCTTTTTGAA

>NZ_CP010525|16|3|3286677-3287269|CRT
GCCTTTTGTCTTTTTAAA	GACCTCTAAAAAACATTGGGACCATCGTACGGATC
CTTTTTTGTCTTTTTGAA	CGTTTTAAAAAGACATTTTGACTCAGTCCCACCC
CCGTTTTGTCTTTTTGAA	GGCTTCTAAAGGACACTTGGACCACTACCCAGAT
CCTTTTTGTCTTTTTGAG	CATCTTAAAAAGACATTTTGGCTCGATCCCCACT
CCTTTTTGTCTTTTTGAA	GGCGTCTAGGGGACATCTTGGGGCGAGAATCATT
GCCTTTTGTCTTTTTGAA	GGTCTCTAAAGGACATTTGGACCTCCGCCCGGATC
CTTTTTTGTCTTTTTGAA	CGTTTTAAAAAGACATTTGGACTCGGTCCCACCT
CCTTTTTGTCTTTTTGAA	GTGTTCTAGGGGACATTTCAGGGTGGGAATCATT
TCCTTTTGTCTTTTAGAA	GGCCTCTAAAGGACACTTGGACCACTGCCCAGAT
CCTTTTTGTCTTTTTAAA	CGTCTTAAAAAGACATTTGGGGGCGGATCCCATT
CCTTTTTGTCTTTTTGAC	GGCTTCTAGGGGACATTTTGAGCTCTGGCCTGATC
CCTTTTTGTCTTTTTGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_172653437.1\|3282985_3283654_-\|phosphoadenylyl-sulfate-reductase	unknown	unknown	gnl\|CDD\|129526
NZ_CP010525.1\|WP_017550718.1\|3289213_3290272_-\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NZ_CP010525.1\|WP_035182685.1\|3280166_3280793_-\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|180667
NZ_CP010525.1\|WP_017550714.1\|3284707_3286111_+\|peptidase-G2	unknown	unknown	gnl\|CDD\|378931
NZ_CP010525.1\|WP_017550705.1\|3275614_3276718_+\|glycerol-dehydrogenase	unknown	unknown	gnl\|CDD\|181843
NZ_CP010525.1\|WP_035182702.1\|3298294_3298882_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274398
NZ_CP010525.1\|WP_035182683.1\|3279503_3280034_-\|YbaK/EbsC-family-protein	unknown	unknown	gnl\|CDD\|239825
NZ_CP010525.1\|WP_035182699.1\|3297175_3297895_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|237084
NZ_CP010525.1\|WP_035182694.1\|3294528_3295773_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173844
NZ_CP010525.1\|WP_035182697.1\|3295959_3296979_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132912
NZ_CP010525.1\|WP_026685136.1\|3293777_3294551_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181295
NZ_CP010525.1\|WP_026685144.1\|3273789_3275382_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|235730
NZ_CP010525.1\|WP_017550717.1\|3287411_3288830_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143421
NZ_CP010525.1\|WP_017550721.1\|3291445_3292009_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380061
NZ_CP010525.1\|WP_017550719.1\|3290314_3290719_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NZ_CP010525.1\|WP_017550713.1\|3284232_3284538_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274982
NZ_CP010525.1\|WP_035182689.1\|3281079_3281820_-\|sirohydrochlorin-chelatase	unknown	unknown	gnl\|CDD\|225049
NZ_CP010525.1\|WP_026685145.1\|3272101_3273142_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP010525.1\|WP_017550720.1\|3290967_3291180_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010525.1\|WP_017550710.1\|3281826_3282585_-\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|381169

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_172653437.1\|3282985_3283654_-\|phosphoadenylyl-sulfate-reductase	gnl\|CDD\|129526	TIGR00434, Phosphoadenosine_phosphosulfate_reductase, phosophoadenylyl-sulfate reductase (thioredoxin). This enzyme, involved in the assimilation of inorganic sulfate, is designated cysH in Bacteria and MET16 in Saccharomyces cerevisiae. Synonyms include phosphoadenosine phosphosulfate reductase, PAPS reductase, and PAPS reductase, thioredoxin-dependent. In a reaction requiring reduced thioredoxin and NADPH, it converts 3(prime)-phosphoadenylylsulfate (PAPS) to sulfite and adenosine 3(prime),5(prime) diphosphate (PAP). A related family of plant enzymes, scoring below the trusted cutoff, differs in having a thioredoxin-like C-terminal domain, not requiring thioredoxin, and in having a preference for 5(prime)-adenylylsulfate (APS) over PAPS. [Central intermediary metabolism, Sulfur metabolism].	4.20671e-110
NZ_CP010525.1\|WP_017550718.1\|3289213_3290272_-\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.15639e-89
NZ_CP010525.1\|WP_035182685.1\|3280166_3280793_-\|NAD(P)-binding-protein	gnl\|CDD\|180667	PRK06718, PRK06718, NAD(P)-binding protein.	8.97864e-78
NZ_CP010525.1\|WP_017550714.1\|3284707_3286111_+\|peptidase-G2	gnl\|CDD\|378931	pfam12708, Pectate_lyase_3, Pectate lyase superfamily protein. This family of proteins possesses a beta helical structure like Pectate lyase. This family is most closely related to glycosyl hydrolase family 28.	1.03555e-14
NZ_CP010525.1\|WP_017550705.1\|3275614_3276718_+\|glycerol-dehydrogenase	gnl\|CDD\|181843	PRK09423, gldA, glycerol dehydrogenase; Provisional.	0
NZ_CP010525.1\|WP_035182702.1\|3298294_3298882_-\|hypothetical-protein	gnl\|CDD\|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	0.00530921
NZ_CP010525.1\|WP_035182683.1\|3279503_3280034_-\|YbaK/EbsC-family-protein	gnl\|CDD\|239825	cd04333, ProX_deacylase, This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro) deacylase and also the cis-acting prolyl-tRNA synthetase-editing domain (ProRS-INS). While ProX and ProRS-INS hydrolyze misacylated Ala-tRNA(Pro), the E. coli YbaK hydrolyzes misacylated Cys-tRNA(Pro). A few CD members are N-terminal, YbaK-ProX-like domains of an uncharacterized protein with a C-terminal, predicted Fe-S protein domain.	1.43622e-74
NZ_CP010525.1\|WP_035182699.1\|3297175_3297895_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|237084	PRK12378, PRK12378, YebC/PmpR family DNA-binding transcriptional regulator.	5.11249e-140
NZ_CP010525.1\|WP_035182694.1\|3294528_3295773_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	0
NZ_CP010525.1\|WP_035182697.1\|3295959_3296979_-\|STAS-domain-containing-protein	gnl\|CDD\|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	3.81405e-36
NZ_CP010525.1\|WP_026685136.1\|3293777_3294551_-\|SDR-family-oxidoreductase	gnl\|CDD\|181295	PRK08213, PRK08213, gluconate 5-dehydrogenase; Provisional.	8.81094e-147
NZ_CP010525.1\|WP_026685144.1\|3273789_3275382_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|235730	PRK06187, PRK06187, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_CP010525.1\|WP_017550717.1\|3287411_3288830_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	gnl\|CDD\|143421	cd07103, ALDH_F5_SSADH_GabD, Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like. Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.	0
NZ_CP010525.1\|WP_017550721.1\|3291445_3292009_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	2.82839e-38
NZ_CP010525.1\|WP_017550719.1\|3290314_3290719_-\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	2.27689e-30
NZ_CP010525.1\|WP_017550713.1\|3284232_3284538_-\|hypothetical-protein	gnl\|CDD\|274982	TIGR04104, hypothetical_protein, cxxc_20_cxxc protein. This small, uncommon, poorly conserved protein is found primarily in the Firmicutes. It features are pair of CxxC motifs separated by about 20 amino acids, followed by a highly hydrophobic region of about 45 amino acids. It has no conserved gene neighborhood, and its function is unknown.	2.23646e-13
NZ_CP010525.1\|WP_035182689.1\|3281079_3281820_-\|sirohydrochlorin-chelatase	gnl\|CDD\|225049	COG2138, COG2138, Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism].	5.92006e-35
NZ_CP010525.1\|WP_026685145.1\|3272101_3273142_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.53117e-53
NZ_CP010525.1\|WP_017550710.1\|3281826_3282585_-\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|381169	cd11642, SUMT, Uroporphyrin-III C-methyltransferase (also known as S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT). SUMT is an enzyme of the cobalamin and siroheme biosynthetic pathway. It catalyzes the first of three steps leading to the formation of siroheme from uroporphyrinogen III; it transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. Precorrin-2 is also a precursor for the biosynthesis of vitamin B12, coenzyme F430, siroheme and heme d1. This family includes proteins in which the SUMT domain is fused to other functional domains, such as to a uroporphyrinogen-III synthase domain to form bifunctional uroporphyrinogen-III methylase/uroporphyrinogen-III synthase, or to a dual function dehydrogenase-chelatase domain, as in the case of the multifunctional S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase/dehydrogenase/ferrochelatase CysG, which catalyzes all three steps that transform uroporphyrinogen III into siroheme.	2.05131e-132

>NZ_CP010525.1|WP_017550714.1|3284707_3286111_+|peptidase-G2
MIHLDKHHDPWTNGILLRQLSRRTVQPGTLIRENEALFQQYCQPEFHKPFSLSRLLLNRRYPVEPYKTLADQNGLVYPEWKTILDQAYSRLLAVASRTVNVADYGAVGDGKTDCTAAFQKALGNGRVKVIVPNGVFLVKGLKLPSWTCLCGSGKGVTIIKLHPHAPKKTRLIQNAHFHRGNHHISVEGLTLDWNVERLGQEERTAAGNNRSSCLTFAHVTFGWVKNVEAVGAGLHGFDVSSARYHYLGDGFLAPGRSRYIWLDGLTASGFGDDGITTHHSDYCFISNSFCYNPSGRAHKKGFSNSNGIEIDDGSRHVWLCNNASSGCFGGVEIKAHHNASAASHVHLYGHLSVRDNRSFNFRHIGHHKGKDADSKSANHIVAANLVSVAPVFTDLYEGSTPRSLVVSAYRNVVINGLTALGDPDYDFKGNPVVAIQYRAKNVILKNVEISGFQNAKRIRGKDKCVLL
>NZ_CP010525.1|WP_017550713.1|3284232_3284538_-|hypothetical-protein
MSLPKCLNCNHQFKWIYIFKRLWKFDQTMECPNCTAKLYPSMKFRNKVGYLSLLCLFVSFGLMILGIPKVAFITLIVIIWVCLILTMPYVYSFDNKERPLW
>NZ_CP010525.1|WP_172653437.1|3282985_3283654_-|phosphoadenylyl-sulfate-reductase
MPEDETKGALEILQWAYGTYGKSVVYACSFGAEGMVLIDLISKVREDADIVFLDTDLHFPQTYELIEKVKKKYPALNIQMKKPSLTLDEQAAQYGSALWKRDPDQCCYIRKIKPLEETLQGAAAWISGLRREQSPTRAKTNFVNKDERFHSIKICPLIHWTWDDVWNYIRSNNLPYNELHDQGYPSIGCFPCTRAVGNSDSRAGRWAGFNKTECGLHTVQKK
>NZ_CP010525.1|WP_017550710.1|3281826_3282585_-|uroporphyrinogen-III-C-methyltransferase
MRKVYLVGAGPGDPELITVKGLRLIREADVILYDRLVNPDLLKEARPDAELVYCGKKPDAHTMTQDMINHLLVKFANQGKTVVRLKGGDPFIFGRGGEEAEVLVQKHIPFEIVPGITAGSAVPAYAGIPLTHRGLSTSVAFIAGVTKKGEDLDAYWSKYAGIDTLCIYMGVKNLPLICAQLIKHGKSPDMPAALIRWGTTEKQETAVSTLGNLSEKAAGLRNPSLLIIGEVVKLREELKWFEQLSAAPACTG
>NZ_CP010525.1|WP_035182689.1|3281079_3281820_-|sirohydrochlorin-chelatase
MKQGVLYVSHGSRVPETAREATATIRQAMAQVDADLQEICYLEIAEPDIAAGIDALVRGGAGRIAVVPVLLLSAGHYYEDIPRAIREAKQRYPHIVFTYGRPLGVGDRIIEILAENILETGMPPGAWILLVGRGSRNPETLCDFAKIAAGLRAQLGTEQIKTAYLAVLEPRFDDALKELTATGHPVVVAPYLWFTGVLVRSLEKKVGMLQREGYDIRLARYLGCHPDMADALAVRAKEALGAEDFI
>NZ_CP010525.1|WP_035182685.1|3280166_3280793_-|NAD(P)-binding-protein
MVWVPVMVDLDGKQAVVIGGGKVAARRFRLLQEAGAYVTVVSPHLNDELQAMAQQRAFIWKQKTFEPEDIRQADVVIAATNDPETNSRIVAHAPAKALVNDAGHAGNGNLAFPAFFQKGRLSISVSTAGASPKLASKIANELSEHYDTNYAQYVDFLYECRQLLKRPQFSPSERSEWLEKLLGEAYRKPEKQQETLSFFHSRIQGTAR
>NZ_CP010525.1|WP_035182683.1|3279503_3280034_-|YbaK/EbsC-family-protein
MSLEDVKAYFKQWDREEDVLVLSSSSATVELAAEALNTEPERIAKTLAFRGTGEEEALLVVTAGDAKIDNKKFRQTFGGKARMLSPEETLEHTGHAVGGVCPFGLKKDLPVYMDVSLKRFTTVFPACGSGNSAIELTCEELYTYGKAEKWVDVCKGWKTVEDYQQVAGTGVLSDPQ
>NZ_CP010525.1|WP_017550705.1|3275614_3276718_+|glycerol-dehydrogenase
MKIPVKSVTSPKKFIVGNGLLANLYAYIKDLGDNAYVICDEFILGRAKEEAGKSVREGGGKATFEQFNYQTTQEEVDRNRRLAREAGANVIVGIGGGKTLDTAKATAYYEKLPVVIFPTIASTDAPCTALAVLYKEDGAFDRYLFLPSNPDVVLADTEILAAAPVRFFAAGIGDALATYFEARACYAANGDNLVLMKPSLTGLAIARTCYETILENGVKAVEAVKNKVPTRAVQDTIEATIYLSGVGAESGGLAAAHAIHNGMTAVPALHRAQHGEKVTFGLLAQLVLENAPKEELETVIRFIKAVGLPLTLKDLGVEEFVEAEWRKVAEDACADDDTMGNEPFPVTPEDVYNAIVAANAIAEKYHD
>NZ_CP010525.1|WP_026685144.1|3273789_3275382_-|long-chain-fatty-acid--CoA-ligase
MNVPLVLTEFLDRAVLLYGGKTAVYCGDRAFTYRELNGRVNRLSYGLKNLGIEKGDRVAYLAPNTVEMLEGFYGIFQLGAVMVPLNIRLTPEDYRFILNHSGSKVLFVDQEMYHLIEPVKDELETVEQIIIHYKEDNCAEIDYDRWLDRFPPDPFPRAGLDENDVCSLLYTSGTTGNPKGVMLTHRNNYLHALSAMHHLRVTDRDVYLHVLPMFHVNGWGSPFYYTANGATHVCLRKPSAEAIFTEIIRHNVTVVHMAPTVLNSLLQYNAEHHPAIEQDVRVVIAGAAPPPAFVERVEKELGWEFIQVYGMTESTPLTLVSVIRSQLGGLDRDTQLRLRAKAGFPMIGSDVRVLRENDEEVAHDGKEIGEVTVRGHGVMLGYWKNPEETMKTIRNGRLYTGDMATVDEYGYIDIVDRKKDIIISGGENISSIEVEGVLYEHPAVLEAAVIAVPHEKWGETPHAFVVRKADAAATEEDIIRFSRERLAHFKAVTGVTFVDELPKTASGKIQKVRLRNEYWEKLGKTERFVN
>NZ_CP010525.1|WP_026685145.1|3272101_3273142_-|GGDEF-domain-containing-protein
MGRKIETLEDFKRILYLWISPLLIAALAIYNLVPHTGTRTALFYLATTRILIAWNALFLICMVFKRYFRLFDYVNLVILTVYYLAIVMDCVFQYMVPGKEGAIGISIIWSPLLFLYIFITLKKRNGIIYSLALFVTTLLIGMPRFRHFSFDYKISMLIFYLANLVYIAIFCISHYLLKVFRELEEEKKKAYSDMLTGIANRRQVQAWLDAAVKHADKTGTSFSVIFFDIDYFKQVNDQFGHQTGDEVLKEFVRLSSRVISANDYIGRWGGEEFIIITKDELPQAEELAEYLKASISRHSFGHAGKLSASFGVTAYTPGDTAETIVRRVDEGLYKSKGQGRNRITVL
>NZ_CP010525.1|WP_017550717.1|3287411_3288830_-|NAD-dependent-succinate-semialdehyde-dehydrogenase
MEDYLMYLNGEWTGEGLPKIKVDNPASGEVIATIPKGGEKEARLAVDAAHTAFPAWAALSAYERSAYLRTWFELIRENENELARTMTIEQGKPLKEALGEMRYANGFIEWFAEEGKRVYGETIPASTTNKRLFVHKQPVGVVAAITPWNFPAAMITRKVAPALAAGCTVVIKPAKQTPLTALKLAELAAKAGIPKGVINVITGSAKEIGDTWLADERVRKLTFTGSTEIGKELMRGSADTVKKVSLELGGHAPVIITKHADLDKAVEGTVAAKFRNAGQTCVCSNRIYVQEEVYEAFTKKFTEKVKALRVGDGLAEGTDIGPLIDRNAVEKVEHHVKDAVEKGATVETGGSAKDGLFFEPTVISNVTDDMICMNEETFGPLAPVTKFTDIDEAIRRANDSIYGLAAYVFTENISEGIQIAEGLEYGIVGLNDGLPSTPQAPFGGFKQSGLGREGGRYGIEEFLEVKYISLGL
>NZ_CP010525.1|WP_017550718.1|3289213_3290272_-|phosphotransferase-family-protein
MHSDTIPVRKGEELDLTRLQEYLQKKFPQMPNVPLGIAQFSAGRSNLTYQLKAGSWEAVLRRPPLGPVAPKAHDMGREFRVLKALRPFFTPAPEVLLFEEDPSVIGAPFFLMERKHGIVLDTAFPPGVEPTKETCRRISGIMVDRLVELHAIPYEKTELLSMSKPDGFLERQVNGWIERYLRAKTDEIPEAEPLIHYLRDHIPPQQGAAVIHYDYKLNNAMFNEDFSEMTGLFDWEMATIGDPLADLGAALSYWTEKDDPDLIKNGLGEPSVTTLDGFMTRREFVEAYAKKSGRDVSNIDYYLIFGYFKLAGICQQIYYRYKRGQTQDQRFAHFGNVVRSLIRHAVEVAERV
>NZ_CP010525.1|WP_017550719.1|3290314_3290719_-|acyl-CoA-thioesterase
MHELKLRTRFCETDAIGHINNTSYFIYLEDARLKFFESIGASVEIKDFNIILASVKCDFVSQAFYNEELTIRTGVAKLGNTSCELAHEILDAETGRLIARGKAVVVFFDFDKQQSRPIPDDIRGILEKHLQTAM
>NZ_CP010525.1|WP_017550720.1|3290967_3291180_-|hypothetical-protein
MQQRINHGQDLEGATPYSFRNEFVLSELHGMKKRITLPQLTENGLVKRRGYSSGSIMARTLQGCKTVQLL
>NZ_CP010525.1|WP_017550721.1|3291445_3292009_-|TetR-family-transcriptional-regulator
MKAKITEHSIRLFEQKGFTETSIQDIVDSIGATKGTFYYYFSSKEQLLMDIHMDYITKLLEKQKAILSENASCKAKLHALVLMLLESIKTEKAKALIFFREIKNLSGEKLELILQKREAFRLGVEKLIREGIEIGEFAEHLDANLTSFAILGMVNWSYQWFNPEGRKSAAEVAELFMDIVLHGIEKA
>NZ_CP010525.1|WP_026685136.1|3293777_3294551_-|SDR-family-oxidoreductase
MNVLELFSLKGKTAIVTGGGRGLGEQIARAFAEAGADVVLCSRKKAACEEAAARIESLGVRALAMECDITNRTQVDEVVAETVKQFGKIDILVNNSGATWGAPAEEMPIEAWEKVISTNVTGTFHMSQAAGKVMIKQGHGKIINIASIAGLGGVDPRIMDTIGYNTSKGAVITFTKDLAAKWGRYGINVNAIAPGFFPTKMAKVIIERGKNPILEATPLGRFGNDQDLKGAAVFLASQASDYVTGDVLLVDGGMHVL
>NZ_CP010525.1|WP_035182694.1|3294528_3295773_-|acyl-CoA-dehydrogenase
MDFDYSPKVKALISKLERFMEENVYPGEKIFEEQLNAQETRWAAVPPIMEELKAKAKQDGLWNLFLPDNEYGAGLSNLEYAPLCEIMGRSIIAPEVFNCNAPDTGNMEVLARYGSDEQKEKWLKPLLNGEIRSCFSMTEPDAASSDATNISCSIVRDGDEYIVNGRKWWSSGAGDPRCKIAIVMGKTNPDAPRHEQQSMILVPLDTPGVKIERMLPVFGYDDAPHGHAEITYENVRVPAENIIWGEGKGFAIAQGRLGPGRIHHCMRLIGAAERALELLCKRIQNRAPFGKPLAEQGVIRQWVAESRIEIEQARLLTLKAAYRMDTVGNKVARKEIAMIKAVAPRMALAVIDRAIQAFGGVGVSDDFPLARLWANARTLRLADGPDEVHLDQIARLEIKPYQERGSADERVRTV
>NZ_CP010525.1|WP_035182697.1|3295959_3296979_-|STAS-domain-containing-protein
MSEHPNIHVGGLQFEWELEKGRFIFEGEDAVLFWIPTAMRDLFTTIEEISGEEASNVVFETAGFRQGLLVADYFNKIKDFDVKKASELITTTYASAGWGRAVMKDMNFDQKTLTIELKDSWEHKINVAQGKKTGSNFLPAHYAGIFTGLFHTNIWYKVVRYQIEGHDSTIIEYFPSDITVSHNIHQLARKKEAEQIIQLEALVEDKTRELKELVKQLSSPIIPILDGIVVVPLIGKYDDERAEELVEKTLKNLPQYKAKYLVLDLTALDVEDDPHSIQFIENIGKASSLIGTQTILVGISPSMSMTISSSGLDFSQFDCFQTLQHSIHYALGQLGRKIL
>NZ_CP010525.1|WP_035182699.1|3297175_3297895_-|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MGRKWNNIKDKKAARDANTSRIYAKFGREIYVAAKQGVPDPVANSALKMVLERAKTYSVPKAIIDRAIEKAKGGADENYDELRYEGFGPGGSMIIVDTLTNNVNRTASEVRAAFGKNGGNMGVSGSVAYMFDKTAVFGIEGKTADEVLELLLEADIDVRDVFEEDGAVIVYAEPDQFHAVQEAFENAGITEFTVAELTMLPQNEVTLPDEDQEKFEKLIDVLEDLEDVQQVYHNVNLGD
>NZ_CP010525.1|WP_035182702.1|3298294_3298882_-|hypothetical-protein
MYKKESGIMDRKIVFGISLVYVLWMAVLCAMQYTAGASWKAAVAAGGVISGAIPLILSWVPRLRFHLPLVISYFLFLTGSQYFGSIRGWYGLGWWDTFLHFVSGLLLGFAAIALYERLVHRDAGKAISAWFVFLFVLGFAALGGVMWEIYEFSGDQFFGTTLQGGGNKDTMTDLIADVLGGLVVATGSGIRTKRK

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Crispr_ID: NZ_CP010525_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010525_17

3519586-3519676

Orphan

Consensus_repeat	Method
TATGCTTGTTCCAGCAAAAGACGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010525_17

>merge|NZ_CP010525|17|3519586-3519676|CRISPRCasFinder
TATGCTTGTTCCAGCAAAAGACGGGATAATGGAATTGCCACTGTACCACGAGTGCCCCCGCCAGGCTATGCTTGTTCCAGCAAAAGACGGG

>NZ_CP010525|17|16|3519586-3519676|CRISPRCasFinder
TATGCTTGTTCCAGCAAAAGACGGG	ATAATGGAATTGCCACTGTACCACGAGTGCCCCCGCCAGGC
TATGCTTGTTCCAGCAAAAGACGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010525.1\|WP_035182964.1\|3514361_3515105_-\|23S-rRNA-(guanosine(2251)-2'-O)-methyltransferase-RlmB	unknown	unknown	gnl\|CDD\|129290
NZ_CP010525.1\|WP_014096516.1\|3513133_3513784_-\|RNA-polymerase-sporulation-sigma-factor-SigH	unknown	unknown	gnl\|CDD\|181361
NZ_CP010525.1\|WP_014096530.1\|3527770_3528316_-\|UvrB/UvrC-motif-containing-protein	unknown	unknown	gnl\|CDD\|226397
NZ_CP010525.1\|WP_017551231.1\|3512678_3512825_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_CP010525.1\|WP_035182969.1\|3516892_3517561_-\|serine-O-acetyltransferase	unknown	unknown	gnl\|CDD\|223975
NZ_CP010525.1\|WP_014096525.1\|3521201_3522287_-\|PIN/TRAM-domain-containing-protein	unknown	unknown	gnl\|CDD\|227292
NZ_CP010525.1\|WP_035182978.1\|3522633_3524004_-\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|236994
NZ_CP010525.1\|WP_014096523.1\|3519975_3520452_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	unknown	unknown	gnl\|CDD\|376811
NZ_CP010525.1\|WP_014096528.1\|3524236_3526687_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|214361
NZ_CP010525.1\|WP_014096524.1\|3520454_3521135_-\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|234670
NZ_CP010525.1\|WP_014096514.1\|3511774_3512308_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_CP010525.1\|WP_014096529.1\|3526703_3527771_-\|protein-arginine-kinase	unknown	unknown	gnl\|CDD\|234894
NZ_CP010525.1\|WP_026684122.1\|3513850_3514360_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|226213
NZ_CP010525.1\|WP_035182972.1\|3517962_3519423_-\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NZ_CP010525.1\|WP_013858048.1\|3528335_3528797_-\|CtsR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226869
NZ_CP010525.1\|WP_014096515.1\|3512457_3512643_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|236066
NZ_CP010525.1\|WP_026684124.1\|3515104_3515518_-\|Mini-ribonuclease-3	unknown	unknown	gnl\|CDD\|224850
NZ_CP010525.1\|WP_035182967.1\|3515514_3516912_-\|cysteine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234705
NZ_CP010525.1\|WP_014096533.1\|3533925_3534192_-\|pro-sigmaK-processing-inhibitor-BofA-family-protein	unknown	unknown	gnl\|CDD\|163046
NZ_CP010525.1\|WP_100183740.1\|3529086_3529344_-\|DUF3969-family-protein	unknown	unknown	gnl\|CDD\|372479

Protein	Function_ID	Function_description	E-value
NZ_CP010525.1\|WP_035182964.1\|3514361_3515105_-\|23S-rRNA-(guanosine(2251)-2'-O)-methyltransferase-RlmB	gnl\|CDD\|129290	TIGR00186, Uncharacterized_tRNA/rRNA_methyltransferase_MG252, rRNA methylase, putative, group 3. this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification].	3.15567e-98
NZ_CP010525.1\|WP_014096516.1\|3513133_3513784_-\|RNA-polymerase-sporulation-sigma-factor-SigH	gnl\|CDD\|181361	PRK08295, PRK08295, RNA polymerase sporulation sigma factor SigH.	5.52162e-120
NZ_CP010525.1\|WP_014096530.1\|3527770_3528316_-\|UvrB/UvrC-motif-containing-protein	gnl\|CDD\|226397	COG3880, COG3880, Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms].	3.16274e-59
NZ_CP010525.1\|WP_017551231.1\|3512678_3512825_-\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	3.43221e-14
NZ_CP010525.1\|WP_035182969.1\|3516892_3517561_-\|serine-O-acetyltransferase	gnl\|CDD\|223975	COG1045, CysE, Serine acetyltransferase [Amino acid transport and metabolism].	1.35616e-102
NZ_CP010525.1\|WP_014096525.1\|3521201_3522287_-\|PIN/TRAM-domain-containing-protein	gnl\|CDD\|227292	COG4956, COG4956, Integral membrane protein (PIN domain superfamily) [General function prediction only].	3.9088e-178
NZ_CP010525.1\|WP_035182978.1\|3522633_3524004_-\|DNA-repair-protein-RadA	gnl\|CDD\|236994	PRK11823, PRK11823, DNA repair protein RadA; Provisional.	0
NZ_CP010525.1\|WP_014096523.1\|3519975_3520452_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	gnl\|CDD\|376811	pfam02542, YgbB, YgbB family. The ygbB protein is a putative enzyme of deoxy-xylulose pathway (terpenoid biosynthesis).	8.76229e-103
NZ_CP010525.1\|WP_014096528.1\|3524236_3526687_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|214361	CHL00095, clpC, Clp protease ATP binding subunit.	0
NZ_CP010525.1\|WP_014096524.1\|3520454_3521135_-\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	gnl\|CDD\|234670	PRK00155, ispD, D-ribitol-5-phosphate cytidylyltransferase.	4.8734e-112
NZ_CP010525.1\|WP_014096514.1\|3511774_3512308_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	6.48023e-95
NZ_CP010525.1\|WP_014096529.1\|3526703_3527771_-\|protein-arginine-kinase	gnl\|CDD\|234894	PRK01059, PRK01059, ATP:guanido phosphotransferase; Provisional.	0
NZ_CP010525.1\|WP_026684122.1\|3513850_3514360_-\|NYN-domain-containing-protein	gnl\|CDD\|226213	COG3688, COG3688, Predicted RNA-binding protein containing a PIN domain [General function prediction only].	3.74279e-75
NZ_CP010525.1\|WP_035182972.1\|3517962_3519423_-\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NZ_CP010525.1\|WP_013858048.1\|3528335_3528797_-\|CtsR-family-transcriptional-regulator	gnl\|CDD\|226869	COG4463, CtsR, Transcriptional repressor of class III stress genes [Transcription].	7.71878e-73
NZ_CP010525.1\|WP_014096515.1\|3512457_3512643_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|236066	PRK07597, secE, preprotein translocase subunit SecE; Reviewed.	2.34704e-14
NZ_CP010525.1\|WP_026684124.1\|3515104_3515518_-\|Mini-ribonuclease-3	gnl\|CDD\|224850	COG1939, COG1939, Ribonuclease III family protein [Replication, recombination, and repair].	5.2684e-60
NZ_CP010525.1\|WP_035182967.1\|3515514_3516912_-\|cysteine--tRNA-ligase	gnl\|CDD\|234705	PRK00260, cysS, cysteinyl-tRNA synthetase; Validated.	0
NZ_CP010525.1\|WP_014096533.1\|3533925_3534192_-\|pro-sigmaK-processing-inhibitor-BofA-family-protein	gnl\|CDD\|163046	TIGR02862, Sigma-K_factor-processing_regulatory_protein_BofA, pro-sigmaK processing inhibitor BofA. Members of this protein family are found only in endospore-forming bacteria, such as Bacillus subtilis and Clostridium tetani. Among such bacteria, it appears only Symbiobacterium thermophilum lacks a member of this family. The protein, designated BofA, is an integral membrane protein that regulates the proteolytic activation of the RNA polymerase sigma factor K. [Cellular processes, Sporulation and germination].	1.78409e-10
NZ_CP010525.1\|WP_100183740.1\|3529086_3529344_-\|DUF3969-family-protein	gnl\|CDD\|372479	pfam13108, DUF3969, Protein of unknown function (DUF3969). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.	1.63373e-07

>NZ_CP010525.1|WP_035182972.1|3517962_3519423_-|glutamate--tRNA-ligase
MANEIRVRYAPSPTGFLHIGNARTALFNYLFARSKGGKFIIRIEDTDQKRNVEGGVESQLKYLKWLGIDWDESIDVGGEYGPYRQSERLDIYKKYYEDLLDRGLAYKCYCTEEELEAEREAQLARGEMPRYSGKCRHLTEEDRKRLEAEGRKPSLRFHVPEGKVYTFNDIVKGEVSFESDGIGDFVIVKKDGMPTYNFAVTIDDHLMKISHVLRGDDHISNTPKQLMIYEAFGFEPPVFGHMTLIVNEHRKKLSKRDGSIIQFIEQYAELGYLPEALFNFIAMLGWSPKGEEEIFSREEFIQIFDPERLSKSPALFDRQKLAWMNNQYMKKLDLDKVVELSLPHLVKAGLVPENRTPEEEQWVRKLISLYQEQMSYGAEIVELSKPLFFTDEITYDEEAKEILSGEHVPEVLRAFLEELDRIEPFEAGEIKKAIKAVQKATGQKGKKLFMPIRVAVSGQTHGPELQSLIELLGREKVKKRLERITG
>NZ_CP010525.1|WP_035182969.1|3516892_3517561_-|serine-O-acetyltransferase
MFKRLKEDIEVVFDQDPAARTYFEVILTYSGLHAIWAHRIAHFFYKKKMFFIARVISQLSRFFTGIEIHPGAQIGRRFFIDHGMGVVIGETCEIGDNVTVYQGVTLGGTGKEKGKRHPTIKDNALIASGAKVLGSITIGENAKIGAGSVVLKDVPPNSTVVGIPGRVVVQDGVKIKKDLKHNELPDPVADRLNSMQQEIDALRSEVEQLRKEGARMYEHSDI
>NZ_CP010525.1|WP_035182967.1|3515514_3516912_-|cysteine--tRNA-ligase
MSIQIYNTLTRKKEPFIPLEEGKVKMYVCGPTVYNYIHIGNARPAIVFDTVRRYLEFRGYDVNYVSNFTDVDDKLIKAAKERGEEVPALSERFIKSYFEDIDALGCCHADAHPRVTENMDTIIAFIEKLIEKGHAYESGGDVYYRTRSFPDYGKLSHQSIDELKSGARIEIGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMAKKYLGDTIDIHAGGQDLTFPHHENEIAQSEALTDKPFARYWMHNGYINIDNEKMSKSLGNIVLVHDIIERHDPQVLRFFMLSVHYRHPINYSEELLANAKAGLERIKTSYQNVKHRLESSANLAEDDEKWLEQVRSLHRQFIEAMDDDFNTANGISVLFELSKQANYYLRGKNTTETVLRAFMKEFETISGVLGLKLEEEVLLDEEIEALIEKRNEARKARNFQLADEIRDKLKSMNIILEDTPQGVRWRRL
>NZ_CP010525.1|WP_026684124.1|3515104_3515518_-|Mini-ribonuclease-3
MTVTLDPKQLNSLALAYMGDAVYEEYIRHHVLLQGKTKPNRLHREAIRFVSAKAQAQVLKQMMNEDLLTEEETAVVRRGRNAKSGTVPKNTDVQTYRHSTAFEALIGYHYLSGSRERMEALIEKAIGIVEDQKGGAR
>NZ_CP010525.1|WP_035182964.1|3514361_3515105_-|23S-rRNA-(guanosine(2251)-2'-O)-methyltransferase-RlmB
MDQEYIAGKNPVLEALRAGREINKIWVAEGSQKGAMKQVMELARERKVTVQFVPKKKIDQVADGAHQGVLALVAAYRYAETGDMFKLAKERNEHPFILILDELEDPHNLGSILRTADAVGAHGVIIPKRRSVALTATVAKASTGAIEHIPVARVTNLSQTIAGLKQQGLWIAGTDASGTTDYRQMDADLPLCLVIGSEGKGMSRIVKEACDFLIRLPMAGHVTSLNASVAAGLLMYEVYRKRHPLGE
>NZ_CP010525.1|WP_026684122.1|3513850_3514360_-|NYN-domain-containing-protein
MNILLVDGYNIIGAWPELQKLKQKDLGAARDRLVEIMAEYQGYTDDKVIVVFDAYGVKGLEKKYRYHKVEVIFTKENETADERIEKMAIKLNNIRTQIYVATSDFTEQWQIFGQGALRISARELLTKVEMIEQKIKKNVKSIQEEKPATRIPLSQEVMEIFEKLRRGKR
>NZ_CP010525.1|WP_014096516.1|3513133_3513784_-|RNA-polymerase-sporulation-sigma-factor-SigH
MNLNIEAAYEERYGTMQDEELVGRIHNGESEALDYLIQKYRNFVRAKARSYFIIGADREDIIQEGMIGLYKAIRDYREDKLTSFKAFAELCINRQMITAIKTATRQKHIPLNSYISLDKPIYDEESDRTLMDVITGAKISNPEELILIREKYVHIEVKISELLSDLERKVLALYLDGQSYQEISEELNRHVKSIDNALQRVKKKLERLLEMREMTY
>NZ_CP010525.1|WP_017551231.1|3512678_3512825_-|50S-ribosomal-protein-L33
MQKKMVLACSVCGSRNYTTTTGNGKAERMELKKFCKHCNEHTIHRGTK
>NZ_CP010525.1|WP_014096515.1|3512457_3512643_-|preprotein-translocase-subunit-SecE
MSITNFFRNVASEMRKVSWPGRKELVKYTITVLVTVAFLTLFFIVIDLGISAVIRWAENSL
>NZ_CP010525.1|WP_014096514.1|3511774_3512308_-|transcription-termination/antitermination-protein-NusG
MEKNWYVVHTYSGYENKVKTNLEKRVESMGMQDKIFRVVVPEEEELEVKNEKKKVVKRKVFPGYVLVEMVMTDDSWYVVRNTPGVTGFVGSSGGGSKPTPLLPEEINTILKRMGMEEKRADVDFEIGETVTVKEGPFANFAGKIVEMDRDKGRAKVMVNMFGRDTPVELVFEQIDKI
>NZ_CP010525.1|WP_014096523.1|3519975_3520452_-|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase
MFRIGQGFDVHRFGEGRPLMIGGVEIPYEKGLLGHSDADVLLHAVADACLGAIGEGDIGRHFPDTDAAFKDADSAALLAHVFQLVKQKGYKLGNLDCTIIAQKPKMAPYIGKMRETIARILEAEIGQVNVKATTTEKLGFAGREEGIAAQAAVLLEQA
>NZ_CP010525.1|WP_014096524.1|3520454_3521135_-|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase
MTDYEVIIPAAGSGKRMGAGFNKLFLELNKRPVIAVTAEVFLADPSCKKLILPVQPHDREEMKRILPRSEKIVFARGGSERQYSVRNGLELAGSCSVILVHDGARPFISAGSIAALAAMAGEKGAAIAAVPVKDTIKRAKDQIVTETIERSSLWQIQTPQAFRTSVLKKAHEAAERDGFLGTDEASLVERIGHPVHIVPGSYDNIKITTPEDLYFAEAILKKQGGG
>NZ_CP010525.1|WP_014096525.1|3521201_3522287_-|PIN/TRAM-domain-containing-protein
MLLRRLIQICLVLIGGTLGVFLLPDFYKLVKVDYVLINNPYVSALLGAIIFYLITFWSIHYIVDFVDWFEDSLVKVPMTEIFSGTFGLVLGLIIAYLASIPVRGIPIVNTIVSITLTVLLGYIGFQVGFKKREEIFNLFFNRQHRRKGGTEQEGHPQPGKQVKILDTSVVIDGRIADICQTGFLDGPIVIPLFVLEELQHIADSSDALKRNRGRRGLDILNRIQNELPIEVQMYEGDFEDIQEVDSKLIKLAKLMNGIVVTNDYNLNKVCEFQKVKVLNINDLANAVKPVVLPGEELNVQLIKDGKEHHQGIAYLDDGTMIVVEEGKNYIGKRIDVLVTSVLQTSAGRMIFAKPKLLEKAL
>NZ_CP010525.1|WP_035182978.1|3522633_3524004_-|DNA-repair-protein-RadA
MAKKTVKFVCQNCGYESPKWMGKCPQCSQWNQMVEEAETPKRRGFFLHPEPGNETKAAPITSIESKEEKRTKVDFGELNRVLGGGIVAGSLVLIGGDPGIGKSTLLLQVSSQLAKHGLNVLYISGEESAKQTKLRADRLNIHTDHLYVLPETDLSVIQQAIDELNPGFVVIDSIQTIYHPEIQSAPGSVSQVRETTAQLMRTAKTKNVAIFIVGHVTKEGSIAGPRVLEHMVDTVLYFEGERHNAYRILRAVKNRFGSTNEIAILEMKESGLEEVQNPSEIFLEERTKGAAGSTVVASIEGTRPVLVEIQALLAPTFFNMPRRMASGIDYNRVTLIMAVLEKRAGLLIQNQDAYLKVAGGLKVDEPAVDLAVAVSVASSFRDKPTNADDCIIGEVGLTGEVRRVSRIEQRVQEAAKLGFRRAIIPKNNMGGWTPPKEIQVIGVSTIQEALQAALGG
>NZ_CP010525.1|WP_014096528.1|3524236_3526687_-|ATP-dependent-Clp-protease-ATP-binding-subunit
MMFGRFTERAQKVLALSQEEAIRLKHNNIGTEHILLGLVREGEGIAAKALYGLGLSAEKIQEEVETLIGNGQEISQTIHYTPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLTNLGVSLNKARQQVLQLLGNSEASVQGGSAASVSTPTLDSLARDLTAIAREDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVHNEVPETLRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRFQPIQVDEPTIDESIQILKGLRDRYEAHHRVSITDEAIEAAVKLSDRYIADRFLPDKAIDLIDEAGSKVRLRSFTTPPNLKELELKLEEVRKEKDAAVQSQEFEKAAALRDTEQKLREQLEETKKNWKAKQGQENSEVTVDDIALVVSSWTGVPVTKLAQTETERLLHLEEILHSRVIGQEEAVLAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAEAMFGDEDAMIRIDMSEYMEKHSTSRLVGSPPGYVGFEEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLDDGRLTDSKGRTVDFSNTIVIMTSNVGADALKRNKSVGFTIQDTVEADYKDMKDKVLEELKKAFRPEFLNRVDETIVFHSLEKKQLNEIVTLMAKELSDRLKEHHIELVLTDAAKEKVAEKGYDPEYGARPLRRSIQKNIEDRLSEEMLKGNIKEGQKVLVDVKDGEFTFASVAESEAVSSNS
>NZ_CP010525.1|WP_014096529.1|3526703_3527771_-|protein-arginine-kinase
MSLEHFLHKASSSWMNEQGPESEIVLTTRVRLARNLKNYRFPSLFTSEEAREIMKTIQDIARNHFPAEMQAEFLKMDELKPLEKRVLVEKHLISPQLAEEAGDGAVILSSGEDISIMINEEDHLRIQCLSPGLQLHETLQKANQLDDLLENWVDYAFDETLGYLTSCPTNVGTGIRASAMMHLPGLVLTQQIKQIIPAIHQLGLVVRGIYGEGSEAIGNIFQISNQVTLGTSEDNIVSDLTSVIRQIITQERSAREALVQTSNIQLEDRVYRSLGVLQNSRIIETKEAARCLSDVRLGIDLGYIQNISKQILNELMILMQPGFLQLYAGRALSPYERDIRRATLIRERLRLEETK
>NZ_CP010525.1|WP_014096530.1|3527770_3528316_-|UvrB/UvrC-motif-containing-protein
MICQECNERPATMHFTKIINGVKTEFHLCEKCAQEKGEKFSSDWGKTFSFDNLLAGLFNFDPAIQLFKQETAPDPDVLRCNHCGMTLNQFLNTSRLGCPHCYETFQHQLVPILQRLHGGNVAHEGKIPARIGGAIYTKKKLQELKAALQEAISQEEFEKAAELRDQIRALEGSSQAKGGEQ
>NZ_CP010525.1|WP_013858048.1|3528335_3528797_-|CtsR-family-transcriptional-regulator
MKNISDIIEEYLKRILELNEKEILEIKRNEIADKFQCVPSQINYVINTRFTIERGYIVESKRGGGGYIRIMKVRPESDAELIDQLLVHIGNVISQSNAEAIILRLVEEEVISRREAKIMLSVMDRSVLYIQLPERDELRARMLKSMLTTLKYK
>NZ_CP010525.1|WP_100183740.1|3529086_3529344_-|DUF3969-family-protein
MLNVLGIIEAVYNKKISIEEAEKRYFNYRIIDSLKEKNYSNELIEILELGTEIDGINDLLPDKLDENIIDLKNRVLLLLDREIKA
>NZ_CP010525.1|WP_014096533.1|3533925_3534192_-|pro-sigmaK-processing-inhibitor-BofA-family-protein
MSSTIIIIAIVGLILLLLFSAALTKPLRWAGKLCIKAIIGAILLFFLNQVGGRYGLHVPINAATVSVSGLLGIPGVIGLTVIQTWILS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP010525_10	10.2\|2497647\|27\|NZ_CP010525\|CRT	2497647-2497673	27	NZ_CP010525.1	2496077-2496103	0	1.0
NZ_CP010525_11	11.1\|2513712\|29\|NZ_CP010525\|CRISPRCasFinder	2513712-2513740	29	NZ_CP010525.1	2511305-2511333	1	0.966
NZ_CP010525_9	9.1\|2433340\|28\|NZ_CP010525\|CRISPRCasFinder	2433340-2433367	28	NZ_CP010525.1	315559-315586	2	0.929
NZ_CP010525_10	10.1\|2497595\|27\|NZ_CP010525\|CRT	2497595-2497621	27	NZ_CP010525.1	2495921-2495947	2	0.926

1. spacer 10.2|2497647|27|NZ_CP010525|CRT matches to position: 2496077-2496103, mismatch: 0, identity: 1.0

cacgttacgtctggatccgaaatgtcc	CRISPR spacer
cacgttacgtctggatccgaaatgtcc	Protospacer
***************************

2. spacer 11.1|2513712|29|NZ_CP010525|CRISPRCasFinder matches to position: 2511305-2511333, mismatch: 1, identity: 0.966

tcgcgttttgtccttcatcaacccggtga	CRISPR spacer
tcgtgttttgtccttcatcaacccggtga	Protospacer
***.*************************

3. spacer 9.1|2433340|28|NZ_CP010525|CRISPRCasFinder matches to position: 315559-315586, mismatch: 2, identity: 0.929

accgtcgtttttccatgcttccttaaca	CRISPR spacer
accttcgtttttccaagcttccttaaca	Protospacer
*** *********** ************

4. spacer 10.1|2497595|27|NZ_CP010525|CRT matches to position: 2495921-2495947, mismatch: 2, identity: 0.926

cacgctgcttccgggtccaaaatgtct	CRISPR spacer
cacgctgtttccgggtccgaaatgtct	Protospacer
*******.**********.********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP010525_10	10.2\|2497647\|27\|NZ_CP010525\|CRT	2497647-2497673	27	MK359332	Streptomyces phage Genie2, complete genome	33877-33903	5	0.815
NZ_CP010525_10	10.2\|2497647\|27\|NZ_CP010525\|CRT	2497647-2497673	27	MK359351	Streptomyces phage BoomerJR, complete genome	33763-33789	5	0.815
NZ_CP010525_10	10.2\|2497647\|27\|NZ_CP010525\|CRT	2497647-2497673	27	MH727564	Streptomyces phage Yaboi, complete genome	33854-33880	5	0.815
NZ_CP010525_7	7.1\|1187106\|55\|NZ_CP010525\|CRISPRCasFinder	1187106-1187160	55	NZ_LR134399	Listeria monocytogenes strain NCTC7974 plasmid 2, complete sequence	57355-57409	6	0.891
NZ_CP010525_11	11.1\|2513712\|29\|NZ_CP010525\|CRISPRCasFinder	2513712-2513740	29	NZ_CP016313	Thermus brockianus strain GE-1 plasmid pTB1, complete sequence	173235-173263	6	0.793
NZ_CP010525_4	4.36\|711504\|34\|NZ_CP010525\|PILER-CR	711504-711537	34	NZ_CP028585	Escherichia coli strain WCHEC4533 plasmid p1_000533, complete sequence	2762-2795	7	0.794
NZ_CP010525_4	4.36\|711504\|34\|NZ_CP010525\|PILER-CR	711504-711537	34	NZ_CP034790	Escherichia coli strain ECCNB20-2 plasmid pTB423, complete sequence	85325-85358	7	0.794
NZ_CP010525_4	4.36\|711504\|34\|NZ_CP010525\|PILER-CR	711504-711537	34	LT906557	Escherichia coli isolate E. coli RL465 genome assembly, plasmid: II	37685-37718	7	0.794
NZ_CP010525_4	4.36\|711504\|34\|NZ_CP010525\|PILER-CR	711504-711537	34	NZ_CP032875	Escherichia coli strain WCHEC000837 plasmid p1_000837, complete sequence	19713-19746	7	0.794
NZ_CP010525_4	4.36\|711504\|34\|NZ_CP010525\|PILER-CR	711504-711537	34	NZ_CP022228	Escherichia coli strain WCHEC96200 plasmid p1_000200, complete sequence	60678-60711	7	0.794
NZ_CP010525_4	4.54\|711503\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711503-711536	34	NZ_CP028585	Escherichia coli strain WCHEC4533 plasmid p1_000533, complete sequence	2762-2795	7	0.794
NZ_CP010525_4	4.54\|711503\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711503-711536	34	NZ_CP034790	Escherichia coli strain ECCNB20-2 plasmid pTB423, complete sequence	85325-85358	7	0.794
NZ_CP010525_4	4.54\|711503\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711503-711536	34	LT906557	Escherichia coli isolate E. coli RL465 genome assembly, plasmid: II	37685-37718	7	0.794
NZ_CP010525_4	4.54\|711503\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711503-711536	34	NZ_CP032875	Escherichia coli strain WCHEC000837 plasmid p1_000837, complete sequence	19713-19746	7	0.794
NZ_CP010525_4	4.54\|711503\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711503-711536	34	NZ_CP022228	Escherichia coli strain WCHEC96200 plasmid p1_000200, complete sequence	60678-60711	7	0.794
NZ_CP010525_7	7.1\|1187106\|55\|NZ_CP010525\|CRISPRCasFinder	1187106-1187160	55	NZ_CP015440	Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_2, complete sequence	64784-64838	7	0.873
NZ_CP010525_4	4.4\|709384\|34\|NZ_CP010525\|PILER-CR,CRISPRCasFinder,CRT	709384-709417	34	KM236247	Bacillus phage Pascal, complete genome	1370-1403	8	0.765
NZ_CP010525_4	4.29\|711041\|34\|NZ_CP010525\|PILER-CR	711041-711074	34	NC_019526	Enterobacteria phage vB_KleM-RaK2, complete genome	245611-245644	8	0.765
NZ_CP010525_4	4.29\|711041\|34\|NZ_CP010525\|PILER-CR	711041-711074	34	MT708547	Klebsiella phage Muenster, complete genome	20967-21000	8	0.765
NZ_CP010525_4	4.29\|711041\|34\|NZ_CP010525\|PILER-CR	711041-711074	34	NZ_CP010057	Hymenobacter sp. DG25B plasmid, complete sequence	93223-93256	8	0.765
NZ_CP010525_4	4.47\|711040\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711040-711073	34	NC_019526	Enterobacteria phage vB_KleM-RaK2, complete genome	245611-245644	8	0.765
NZ_CP010525_4	4.47\|711040\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711040-711073	34	MT708547	Klebsiella phage Muenster, complete genome	20967-21000	8	0.765
NZ_CP010525_4	4.47\|711040\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711040-711073	34	NZ_CP010057	Hymenobacter sp. DG25B plasmid, complete sequence	93223-93256	8	0.765
NZ_CP010525_7	7.1\|1187106\|55\|NZ_CP010525\|CRISPRCasFinder	1187106-1187160	55	NZ_CP015439	Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence	255881-255935	8	0.855
NZ_CP010525_4	4.2\|709254\|33\|NZ_CP010525\|PILER-CR,CRISPRCasFinder,CRT	709254-709286	33	NZ_CP039708	Lactobacillus paracasei strain Lp02 plasmid pLp02-1, complete sequence	52162-52194	9	0.727
NZ_CP010525_4	4.6\|709518\|34\|NZ_CP010525\|PILER-CR,CRISPRCasFinder,CRT	709518-709551	34	NZ_CP010727	Phaeobacter inhibens strain P88 plasmid pP88_b, complete sequence	72779-72812	9	0.735
NZ_CP010525_4	4.17\|710247\|34\|NZ_CP010525\|PILER-CR,CRISPRCasFinder,CRT	710247-710280	34	NZ_AP017562	Pseudanabaena sp. ABRG5-3 plasmid ABRG53b, complete sequence	30985-31018	9	0.735
NZ_CP010525_7	7.1\|1187106\|55\|NZ_CP010525\|CRISPRCasFinder	1187106-1187160	55	NZ_CP024037	Bacillus aryabhattai strain K13 plasmid unnamed2	10428-10482	9	0.836
NZ_CP010525_7	7.1\|1187106\|55\|NZ_CP010525\|CRISPRCasFinder	1187106-1187160	55	NZ_CP026740	Bacillus megaterium strain YC4-R4 plasmid unnamed4	70775-70829	9	0.836
NZ_CP010525_7	7.1\|1187106\|55\|NZ_CP010525\|CRISPRCasFinder	1187106-1187160	55	NZ_CP010587	Bacillus megaterium Q3 plasmid p1, complete sequence	832-886	9	0.836
NZ_CP010525_7	7.1\|1187106\|55\|NZ_CP010525\|CRISPRCasFinder	1187106-1187160	55	NZ_CP023319	Bacillus megaterium strain A plasmid p2, complete sequence	75819-75873	9	0.836
NZ_CP010525_7	7.1\|1187106\|55\|NZ_CP010525\|CRISPRCasFinder	1187106-1187160	55	NC_017139	Bacillus megaterium WSH-002 plasmid WSH-002_p1, complete sequence	1329-1383	9	0.836
NZ_CP010525_7	7.1\|1187106\|55\|NZ_CP010525\|CRISPRCasFinder	1187106-1187160	55	NC_020451	Vibrio coralliilyticus strain ATCC BAA-450 plasmid, complete sequence	1971-2025	9	0.836
NZ_CP010525_4	4.15\|710116\|34\|NZ_CP010525\|PILER-CR,CRISPRCasFinder,CRT	710116-710149	34	NC_021289	Burkholderia insecticola plasmid p1, complete sequence	818211-818244	10	0.706
NZ_CP010525_4	4.18\|710313\|34\|NZ_CP010525\|PILER-CR,CRISPRCasFinder,CRT	710313-710346	34	MN234226	Mycobacterium phage Curiosium, complete genome	22482-22515	10	0.706
NZ_CP010525_4	4.29\|711041\|34\|NZ_CP010525\|PILER-CR	711041-711074	34	NZ_CP020349	Pasteurella multocida subsp. septica strain CIRMBP-0873 plasmid unnamed2, complete sequence	93-126	10	0.706
NZ_CP010525_4	4.47\|711040\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711040-711073	34	NZ_CP020349	Pasteurella multocida subsp. septica strain CIRMBP-0873 plasmid unnamed2, complete sequence	93-126	10	0.706
NZ_CP010525_7	7.1\|1187106\|55\|NZ_CP010525\|CRISPRCasFinder	1187106-1187160	55	NC_048753	Lactobacillus phage 3-521, complete genome	13549-13603	10	0.818
NZ_CP010525_4	4.14\|710050\|34\|NZ_CP010525\|PILER-CR,CRISPRCasFinder,CRT	710050-710083	34	NZ_CP034187	Deinococcus sp. S14-83 strain S14-83T plasmid unnamed3, complete sequence	140828-140861	11	0.676
NZ_CP010525_4	4.29\|711041\|34\|NZ_CP010525\|PILER-CR	711041-711074	34	NZ_CP018877	Bacillus megaterium strain JX285 plasmid 4, complete sequence	4012-4045	11	0.676
NZ_CP010525_4	4.47\|711040\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711040-711073	34	NZ_CP018877	Bacillus megaterium strain JX285 plasmid 4, complete sequence	4012-4045	11	0.676
NZ_CP010525_7	7.1\|1187106\|55\|NZ_CP010525\|CRISPRCasFinder	1187106-1187160	55	NZ_CP033045	Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence	483785-483839	11	0.8
NZ_CP010525_4	4.5\|709450\|36\|NZ_CP010525\|PILER-CR,CRISPRCasFinder,CRT	709450-709485	36	MF351863	Synechococcus phage Bellamy, complete genome	93165-93200	12	0.667
NZ_CP010525_4	4.21\|710510\|34\|NZ_CP010525\|PILER-CR,CRISPRCasFinder,CRT	710510-710543	34	NZ_CP039965	Pseudorhodobacter sp. S12M18 plasmid unnamed1, complete sequence	1548793-1548826	12	0.647
NZ_CP010525_4	4.29\|711041\|34\|NZ_CP010525\|PILER-CR	711041-711074	34	CP041518	Bacillus aryabhattai strain KNU10 plasmid unnamed2, complete sequence	88586-88619	12	0.647
NZ_CP010525_4	4.29\|711041\|34\|NZ_CP010525\|PILER-CR	711041-711074	34	NZ_CP041064	Bacillus megaterium strain KNU-01 plasmid pKNU_01_1, complete sequence	102067-102100	12	0.647
NZ_CP010525_4	4.29\|711041\|34\|NZ_CP010525\|PILER-CR	711041-711074	34	NZ_CP018876	Bacillus megaterium strain JX285 plasmid 3, complete sequence	15377-15410	12	0.647
NZ_CP010525_4	4.47\|711040\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711040-711073	34	CP041518	Bacillus aryabhattai strain KNU10 plasmid unnamed2, complete sequence	88586-88619	12	0.647
NZ_CP010525_4	4.47\|711040\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711040-711073	34	NZ_CP041064	Bacillus megaterium strain KNU-01 plasmid pKNU_01_1, complete sequence	102067-102100	12	0.647
NZ_CP010525_4	4.47\|711040\|34\|NZ_CP010525\|CRT,CRISPRCasFinder	711040-711073	34	NZ_CP018876	Bacillus megaterium strain JX285 plasmid 3, complete sequence	15377-15410	12	0.647

1. spacer 10.2|2497647|27|NZ_CP010525|CRT matches to MK359332 (Streptomyces phage Genie2, complete genome) position: , mismatch: 5, identity: 0.815

cacgttacgtctggatccgaaatgtcc	CRISPR spacer
cgcgttacctctgcatccgaaatgtat	Protospacer
*.****** **** *********** .

2. spacer 10.2|2497647|27|NZ_CP010525|CRT matches to MK359351 (Streptomyces phage BoomerJR, complete genome) position: , mismatch: 5, identity: 0.815

cacgttacgtctggatccgaaatgtcc	CRISPR spacer
cgcgttacctctgcatccgaaatgtat	Protospacer
*.****** **** *********** .

3. spacer 10.2|2497647|27|NZ_CP010525|CRT matches to MH727564 (Streptomyces phage Yaboi, complete genome) position: , mismatch: 5, identity: 0.815

cacgttacgtctggatccgaaatgtcc	CRISPR spacer
cgcgttacctctgcatccgaaatgtat	Protospacer
*.****** **** *********** .

4. spacer 7.1|1187106|55|NZ_CP010525|CRISPRCasFinder matches to NZ_LR134399 (Listeria monocytogenes strain NCTC7974 plasmid 2, complete sequence) position: , mismatch: 6, identity: 0.891

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
cttactatgcgggtgtagtttagtggtaaaactacagccttccaagctgttgtcg	Protospacer
*.* .  *************************.**********************

5. spacer 11.1|2513712|29|NZ_CP010525|CRISPRCasFinder matches to NZ_CP016313 (Thermus brockianus strain GE-1 plasmid pTB1, complete sequence) position: , mismatch: 6, identity: 0.793

tcgcgttttgtccttcatcaacccggtga	CRISPR spacer
agggggtttggccttcttcaacccggtga	Protospacer
  * * **** ***** ************

6. spacer 4.36|711504|34|NZ_CP010525|PILER-CR matches to NZ_CP028585 (Escherichia coli strain WCHEC4533 plasmid p1_000533, complete sequence) position: , mismatch: 7, identity: 0.794

tgccggaggacctggatacagctatccagcatta	CRISPR spacer
tgatggagaacctggataaagctatccagaagga	Protospacer
** .****.********* ********** *  *

7. spacer 4.36|711504|34|NZ_CP010525|PILER-CR matches to NZ_CP034790 (Escherichia coli strain ECCNB20-2 plasmid pTB423, complete sequence) position: , mismatch: 7, identity: 0.794

tgccggaggacctggatacagctatccagcatta	CRISPR spacer
tgatggagaacctggataaagctatccagaagga	Protospacer
** .****.********* ********** *  *

8. spacer 4.36|711504|34|NZ_CP010525|PILER-CR matches to LT906557 (Escherichia coli isolate E. coli RL465 genome assembly, plasmid: II) position: , mismatch: 7, identity: 0.794

tgccggaggacctggatacagctatccagcatta	CRISPR spacer
tgatggagaacctggataaagctatccagaagga	Protospacer
** .****.********* ********** *  *

9. spacer 4.36|711504|34|NZ_CP010525|PILER-CR matches to NZ_CP032875 (Escherichia coli strain WCHEC000837 plasmid p1_000837, complete sequence) position: , mismatch: 7, identity: 0.794

tgccggaggacctggatacagctatccagcatta	CRISPR spacer
tgatggagaacctggataaagctatccagaagga	Protospacer
** .****.********* ********** *  *

10. spacer 4.36|711504|34|NZ_CP010525|PILER-CR matches to NZ_CP022228 (Escherichia coli strain WCHEC96200 plasmid p1_000200, complete sequence) position: , mismatch: 7, identity: 0.794

tgccggaggacctggatacagctatccagcatta	CRISPR spacer
tgatggagaacctggataaagctatccagaagga	Protospacer
** .****.********* ********** *  *

11. spacer 4.54|711503|34|NZ_CP010525|CRT,CRISPRCasFinder matches to NZ_CP028585 (Escherichia coli strain WCHEC4533 plasmid p1_000533, complete sequence) position: , mismatch: 7, identity: 0.794

tgccggaggacctggatacagctatccagcatta	CRISPR spacer
tgatggagaacctggataaagctatccagaagga	Protospacer
** .****.********* ********** *  *

12. spacer 4.54|711503|34|NZ_CP010525|CRT,CRISPRCasFinder matches to NZ_CP034790 (Escherichia coli strain ECCNB20-2 plasmid pTB423, complete sequence) position: , mismatch: 7, identity: 0.794

tgccggaggacctggatacagctatccagcatta	CRISPR spacer
tgatggagaacctggataaagctatccagaagga	Protospacer
** .****.********* ********** *  *

13. spacer 4.54|711503|34|NZ_CP010525|CRT,CRISPRCasFinder matches to LT906557 (Escherichia coli isolate E. coli RL465 genome assembly, plasmid: II) position: , mismatch: 7, identity: 0.794

tgccggaggacctggatacagctatccagcatta	CRISPR spacer
tgatggagaacctggataaagctatccagaagga	Protospacer
** .****.********* ********** *  *

14. spacer 4.54|711503|34|NZ_CP010525|CRT,CRISPRCasFinder matches to NZ_CP032875 (Escherichia coli strain WCHEC000837 plasmid p1_000837, complete sequence) position: , mismatch: 7, identity: 0.794

tgccggaggacctggatacagctatccagcatta	CRISPR spacer
tgatggagaacctggataaagctatccagaagga	Protospacer
** .****.********* ********** *  *

15. spacer 4.54|711503|34|NZ_CP010525|CRT,CRISPRCasFinder matches to NZ_CP022228 (Escherichia coli strain WCHEC96200 plasmid p1_000200, complete sequence) position: , mismatch: 7, identity: 0.794

tgccggaggacctggatacagctatccagcatta	CRISPR spacer
tgatggagaacctggataaagctatccagaagga	Protospacer
** .****.********* ********** *  *

16. spacer 7.1|1187106|55|NZ_CP010525|CRISPRCasFinder matches to NZ_CP015440 (Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_2, complete sequence) position: , mismatch: 7, identity: 0.873

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
attattatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
 .* *  ************************** *************** *****

17. spacer 4.4|709384|34|NZ_CP010525|PILER-CR,CRISPRCasFinder,CRT matches to KM236247 (Bacillus phage Pascal, complete genome) position: , mismatch: 8, identity: 0.765

ccaaacgatcagggataaagtatgggatgagtgg	CRISPR spacer
cgaaagccgaagggataaaatatgggatgaatgg	Protospacer
* ***     *********.**********.***

18. spacer 4.29|711041|34|NZ_CP010525|PILER-CR matches to NC_019526 (Enterobacteria phage vB_KleM-RaK2, complete genome) position: , mismatch: 8, identity: 0.765

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
tttctttgccattttttgattcctcaccaatgag	Protospacer
***************** ******* ... **

19. spacer 4.29|711041|34|NZ_CP010525|PILER-CR matches to MT708547 (Klebsiella phage Muenster, complete genome) position: , mismatch: 8, identity: 0.765

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
tttctttgccattttttgattcctcaccaatgag	Protospacer
***************** ******* ... **

20. spacer 4.29|711041|34|NZ_CP010525|PILER-CR matches to NZ_CP010057 (Hymenobacter sp. DG25B plasmid, complete sequence) position: , mismatch: 8, identity: 0.765

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
tgtccttgccattttttaattcctcctgggccat	Protospacer
* **.************ ********* * .  *

21. spacer 4.47|711040|34|NZ_CP010525|CRT,CRISPRCasFinder matches to NC_019526 (Enterobacteria phage vB_KleM-RaK2, complete genome) position: , mismatch: 8, identity: 0.765

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
tttctttgccattttttgattcctcaccaatgag	Protospacer
***************** ******* ... **

22. spacer 4.47|711040|34|NZ_CP010525|CRT,CRISPRCasFinder matches to MT708547 (Klebsiella phage Muenster, complete genome) position: , mismatch: 8, identity: 0.765

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
tttctttgccattttttgattcctcaccaatgag	Protospacer
***************** ******* ... **

23. spacer 4.47|711040|34|NZ_CP010525|CRT,CRISPRCasFinder matches to NZ_CP010057 (Hymenobacter sp. DG25B plasmid, complete sequence) position: , mismatch: 8, identity: 0.765

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
tgtccttgccattttttaattcctcctgggccat	Protospacer
* **.************ ********* * .  *

24. spacer 7.1|1187106|55|NZ_CP010525|CRISPRCasFinder matches to NZ_CP015439 (Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence) position: , mismatch: 8, identity: 0.855

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
tataatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
. *    ************************** *************** *****

25. spacer 4.2|709254|33|NZ_CP010525|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039708 (Lactobacillus paracasei strain Lp02 plasmid pLp02-1, complete sequence) position: , mismatch: 9, identity: 0.727

atcaagcggaaagcacgttggcaaatgggcggt	CRISPR spacer
atcaagcggaaagctagttggcaagagatgtgc	Protospacer
**************  ********. *.   *.

26. spacer 4.6|709518|34|NZ_CP010525|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP010727 (Phaeobacter inhibens strain P88 plasmid pP88_b, complete sequence) position: , mismatch: 9, identity: 0.735

ttcccgctgctggttgatcagctttttctgttct	CRISPR spacer
ttgccgctgctgcttgatcagcttgacctgccag	Protospacer
** ********* ***********  .***..

27. spacer 4.17|710247|34|NZ_CP010525|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP017562 (Pseudanabaena sp. ABRG5-3 plasmid ABRG53b, complete sequence) position: , mismatch: 9, identity: 0.735

gttgcagaacaaggctttgatggcatcgattata	CRISPR spacer
gttgcagaacaagtctttggtggcttaggaggca	Protospacer
************* *****.**** * *.  ..*

28. spacer 7.1|1187106|55|NZ_CP010525|CRISPRCasFinder matches to NZ_CP024037 (Bacillus aryabhattai strain K13 plasmid unnamed2) position: , mismatch: 9, identity: 0.836

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
taaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
.      ************************** *************** *****

29. spacer 7.1|1187106|55|NZ_CP010525|CRISPRCasFinder matches to NZ_CP026740 (Bacillus megaterium strain YC4-R4 plasmid unnamed4) position: , mismatch: 9, identity: 0.836

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
taaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
.      ************************** *************** *****

30. spacer 7.1|1187106|55|NZ_CP010525|CRISPRCasFinder matches to NZ_CP010587 (Bacillus megaterium Q3 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.836

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
taaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
.      ************************** *************** *****

31. spacer 7.1|1187106|55|NZ_CP010525|CRISPRCasFinder matches to NZ_CP023319 (Bacillus megaterium strain A plasmid p2, complete sequence) position: , mismatch: 9, identity: 0.836

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
taaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
.      ************************** *************** *****

32. spacer 7.1|1187106|55|NZ_CP010525|CRISPRCasFinder matches to NC_017139 (Bacillus megaterium WSH-002 plasmid WSH-002_p1, complete sequence) position: , mismatch: 9, identity: 0.836

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
taaaatatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgtcg	Protospacer
.      ************************** *************** *****

33. spacer 7.1|1187106|55|NZ_CP010525|CRISPRCasFinder matches to NC_020451 (Vibrio coralliilyticus strain ATCC BAA-450 plasmid, complete sequence) position: , mismatch: 9, identity: 0.836

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
actaaaatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgatg	Protospacer
 **  . ************************** *************** ** .*

34. spacer 4.15|710116|34|NZ_CP010525|PILER-CR,CRISPRCasFinder,CRT matches to NC_021289 (Burkholderia insecticola plasmid p1, complete sequence) position: , mismatch: 10, identity: 0.706

gaacttaacgacggaatcgaactcgacagcgacg	CRISPR spacer
cgcgacggcgactggatcgaactcgacagcgacg	Protospacer
 .   ...**** *.*******************

35. spacer 4.18|710313|34|NZ_CP010525|PILER-CR,CRISPRCasFinder,CRT matches to MN234226 (Mycobacterium phage Curiosium, complete genome) position: , mismatch: 10, identity: 0.706

ccgtcatcaattttgcaccggattgtgcatcctg	CRISPR spacer
acgtcaccaatgttgcaccggattgccgcggttg	Protospacer
 *****.**** *************.     .**

36. spacer 4.29|711041|34|NZ_CP010525|PILER-CR matches to NZ_CP020349 (Pasteurella multocida subsp. septica strain CIRMBP-0873 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.706

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
tccttttgccattttttctttccttcttttaaac	Protospacer
*...************** *****.*** * . .

37. spacer 4.47|711040|34|NZ_CP010525|CRT,CRISPRCasFinder matches to NZ_CP020349 (Pasteurella multocida subsp. septica strain CIRMBP-0873 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.706

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
tccttttgccattttttctttccttcttttaaac	Protospacer
*...************** *****.*** * . .

38. spacer 7.1|1187106|55|NZ_CP010525|CRISPRCasFinder matches to NC_048753 (Lactobacillus phage 3-521, complete genome) position: , mismatch: 10, identity: 0.818

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
tagttcacgcgggtatagtttagtggtaaaaccacagccttccaagctgtagatg	Protospacer
.  **  .******.*********************************** * .*

39. spacer 4.14|710050|34|NZ_CP010525|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034187 (Deinococcus sp. S14-83 strain S14-83T plasmid unnamed3, complete sequence) position: , mismatch: 11, identity: 0.676

gtagacaatgcgttgtaattccgagtcaaaaagt	CRISPR spacer
gcgtgcaatgcgttgtaattccttgtcaatccta	Protospacer
*.. .*****************  *****

40. spacer 4.29|711041|34|NZ_CP010525|PILER-CR matches to NZ_CP018877 (Bacillus megaterium strain JX285 plasmid 4, complete sequence) position: , mismatch: 11, identity: 0.676

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
aatggacgccattttttcattcctctatgttcca	Protospacer
  *   .******************. **** .

41. spacer 4.47|711040|34|NZ_CP010525|CRT,CRISPRCasFinder matches to NZ_CP018877 (Bacillus megaterium strain JX285 plasmid 4, complete sequence) position: , mismatch: 11, identity: 0.676

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
aatggacgccattttttcattcctctatgttcca	Protospacer
  *   .******************. **** .

42. spacer 7.1|1187106|55|NZ_CP010525|CRISPRCasFinder matches to NZ_CP033045 (Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.8

cctttgctgcgggtgtagtttagtggtaaaaccacagccttccaagctgttgtcg	CRISPR spacer
ttaaccatgcgggtgtagtttagtggtaaaacctcagccttccaagctgatgatg	Protospacer
..  .  ************************** *************** ** .*

43. spacer 4.5|709450|36|NZ_CP010525|PILER-CR,CRISPRCasFinder,CRT matches to MF351863 (Synechococcus phage Bellamy, complete genome) position: , mismatch: 12, identity: 0.667

atctaattcaactaatgaaccgtcatcgtatctgct	CRISPR spacer
tgctaattcaacaaatgaaccatcatcgaggtcatc	Protospacer
  ********** ********.****** . .....

44. spacer 4.21|710510|34|NZ_CP010525|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039965 (Pseudorhodobacter sp. S12M18 plasmid unnamed1, complete sequence) position: , mismatch: 12, identity: 0.647

tatgcgcagctggcctgtctctaccgcctgcatt	CRISPR spacer
ggccagcggctggcctgcctctaccgcctcgccc	Protospacer
 ..  **.*********.***********   ..

45. spacer 4.29|711041|34|NZ_CP010525|PILER-CR matches to CP041518 (Bacillus aryabhattai strain KNU10 plasmid unnamed2, complete sequence) position: , mismatch: 12, identity: 0.647

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
aaagggcgccattttttcattcctctatgttcca	Protospacer
      .******************. **** .

46. spacer 4.29|711041|34|NZ_CP010525|PILER-CR matches to NZ_CP041064 (Bacillus megaterium strain KNU-01 plasmid pKNU_01_1, complete sequence) position: , mismatch: 12, identity: 0.647

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
aaagggcgccattttttcattcctctatgttcca	Protospacer
      .******************. **** .

47. spacer 4.29|711041|34|NZ_CP010525|PILER-CR matches to NZ_CP018876 (Bacillus megaterium strain JX285 plasmid 3, complete sequence) position: , mismatch: 12, identity: 0.647

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
aaagggcgccattttttcattcctctatgttcca	Protospacer
      .******************. **** .

48. spacer 4.47|711040|34|NZ_CP010525|CRT,CRISPRCasFinder matches to CP041518 (Bacillus aryabhattai strain KNU10 plasmid unnamed2, complete sequence) position: , mismatch: 12, identity: 0.647

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
aaagggcgccattttttcattcctctatgttcca	Protospacer
      .******************. **** .

49. spacer 4.47|711040|34|NZ_CP010525|CRT,CRISPRCasFinder matches to NZ_CP041064 (Bacillus megaterium strain KNU-01 plasmid pKNU_01_1, complete sequence) position: , mismatch: 12, identity: 0.647

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
aaagggcgccattttttcattcctctatgttcca	Protospacer
      .******************. **** .

50. spacer 4.47|711040|34|NZ_CP010525|CRT,CRISPRCasFinder matches to NZ_CP018876 (Bacillus megaterium strain JX285 plasmid 3, complete sequence) position: , mismatch: 12, identity: 0.647

tttctttgccattttttcattcctccttgttgtt	CRISPR spacer
aaagggcgccattttttcattcctctatgttcca	Protospacer
      .******************. **** .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

12631 : 20694

Staphylococcus_phage(66.67%)

protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_017550665.1\|12631_13255_-\|protease	spore protease YyaC	G3M9W0	Bacillus_virus	3.6e-22	38.5
WP_014096615.1\|13469_14381_+	mechanosensitive ion channel family protein	NA	NA	NA	NA
WP_013860891.1\|14370_14571_+	DUF951 domain-containing protein	NA	NA	NA	NA
WP_014096616.1\|14731_15832_+	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_142010213.1\|16153_17275_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	2.9e-54	37.0
WP_035183081.1\|17255_17903_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	2.6e-39	44.8
WP_035183084.1\|17920_19114_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	2.1e-111	53.8
WP_014096620.1\|19126_19597_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	2.2e-40	55.9
WP_014096621.1\|19850_20138_+	30S ribosomal protein S6	NA	NA	NA	NA
WP_014096622.1\|20199_20694_+	single-stranded DNA-binding protein	A8ATZ7	Listeria_phage	2.8e-54	67.7

DBSCAN-SWA_2

90734 : 155848

Enterobacteria_phage(15.38%)

coat,tRNA,bacteriocin,transposase,holin,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_043052461.1\|90734_92255_-\|transposase	IS5-like element ISBco3 family transposase	NA	NA	NA	NA
WP_172653422.1\|92399_93104_-	deoxyribose-phosphate aldolase	NA	NA	NA	NA
WP_017552045.1\|93530_95255_+	ubiquinone-dependent pyruvate dehydrogenase	G8DDL3	Micromonas_pusilla_virus	1.1e-36	23.4
WP_014096666.1\|95462_96743_-	uracil permease	Q9KX94	Enterobacteria_phage	3.9e-63	37.4
WP_014096667.1\|97864_99367_+	DHA2 family efflux MFS transporter permease subunit	NA	NA	NA	NA
WP_035183142.1\|99887_101120_-	peptidase T	NA	NA	NA	NA
WP_035183143.1\|101182_101977_-	glycosyltransferase family 8 protein	NA	NA	NA	NA
WP_035183145.1\|102170_103520_-	MATE family efflux transporter	NA	NA	NA	NA
WP_035183146.1\|103936_105115_+	ParM/StbA family protein	A0A1B1P792	Bacillus_phage	5.5e-56	35.3
WP_014096674.1\|105126_105699_+	hypothetical protein	NA	NA	NA	NA
WP_035183148.1\|105760_106540_+	ABC transporter ATP-binding protein	F2Y302	Organic_Lake_phycodnavirus	4.6e-11	25.3
WP_014096676.1\|106802_107843_+	methionine ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.1e-34	39.4
WP_014096677.1\|107832_108495_+	ABC transporter permease	NA	NA	NA	NA
WP_014096678.1\|108556_109399_+	MetQ/NlpA family ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_035183149.1\|109634_111416_+	sensor histidine kinase	Q9EYF3	Enterobacteria_phage	7.2e-68	32.0
WP_035183151.1\|111390_112107_+	LytTR family transcriptional regulator DNA-binding domain-containing protein	NA	NA	NA	NA
WP_035183153.1\|112237_114040_+	carbon starvation protein A	NA	NA	NA	NA
WP_014096682.1\|114379_115453_+	branched-chain amino acid aminotransferase	NA	NA	NA	NA
WP_014096683.1\|115906_116656_+	threonine/serine exporter family protein	NA	NA	NA	NA
WP_014096684.1\|116731_117178_+	threonine/serine exporter family protein	NA	NA	NA	NA
WP_014096933.1\|117950_119312_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_035183159.1\|120162_121176_-	DUF1646 family protein	NA	NA	NA	NA
WP_035183161.1\|121529_123377_+	asparagine synthase (glutamine-hydrolyzing)	F2Y1H0	Organic_Lake_phycodnavirus	1.3e-30	27.0
WP_014096689.1\|123525_124467_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_035183163.1\|124569_124947_+\|holin	CidA/LrgA family holin-like protein	NA	NA	NA	NA
WP_026684575.1\|124936_125620_+	LrgB family protein	NA	NA	NA	NA
WP_164931356.1\|125689_125836_+	hypothetical protein	NA	NA	NA	NA
WP_035183165.1\|125943_126423_+\|tRNA	Cys-tRNA(Pro) deacylase	NA	NA	NA	NA
WP_164931355.1\|126499_126676_+	hypothetical protein	NA	NA	NA	NA
WP_035183167.1\|127547_128414_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_035183170.1\|128669_129518_+	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_035183171.1\|129644_130916_+	alkaline phosphatase	NA	NA	NA	NA
WP_035183173.1\|131018_133193_+	DNA helicase RecQ	J2YAJ8	Acanthamoeba_polyphaga_lentillevirus	1.0e-84	37.4
WP_035183175.1\|133197_134064_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_014096699.1\|134174_134858_-	bacillithiol biosynthesis deacetylase BshB2	NA	NA	NA	NA
WP_013860797.1\|134871_135219_-	YojF family protein	NA	NA	NA	NA
WP_014096700.1\|135338_136157_-	pyridoxine/pyridoxal/pyridoxamine kinase	NA	NA	NA	NA
WP_014096701.1\|136522_137716_+	MFS transporter	NA	NA	NA	NA
WP_157660066.1\|138067_138742_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	1.9e-16	29.6
WP_035183181.1\|138747_139392_+	ABC-2 transporter permease	NA	NA	NA	NA
WP_013860793.1\|139783_139951_-	hypothetical protein	NA	NA	NA	NA
WP_080738159.1\|139947_140634_-	ABC transporter ATP-binding protein	A0A1V0SE00	Indivirus	3.3e-13	28.8
WP_013860791.1\|141194_142820_-	hypothetical protein	NA	NA	NA	NA
WP_017550351.1\|142894_143122_-\|bacteriocin	circular bacteriocin, circularin A/uberolysin family	NA	NA	NA	NA
WP_017550349.1\|143601_143874_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_026684561.1\|143998_144346_-	general stress protein	NA	NA	NA	NA
WP_026684560.1\|144495_145182_+	uracil-DNA glycosylase	A0A0B5IW78	Pandoravirus	3.4e-50	45.1
WP_014096710.1\|145631_145889_+	YwdI family protein	NA	NA	NA	NA
WP_014096711.1\|146060_146432_+	DUF423 domain-containing protein	NA	NA	NA	NA
WP_014096712.1\|146474_146921_-\|coat	spore coat protein GerQ	NA	NA	NA	NA
WP_014096713.1\|147081_147837_-	heme-dependent peroxidase	NA	NA	NA	NA
WP_035183186.1\|148006_148978_+	phosphate acetyltransferase	NA	NA	NA	NA
WP_035183189.1\|149768_150602_+	lipoate--protein ligase family protein	NA	NA	NA	NA
WP_014096716.1\|151784_152495_-	RsfA family transcriptional regulator	A0A1D6X8E5	Bacillus_phage	4.1e-06	50.0
WP_014096717.1\|152987_154304_+	HD domain-containing protein	E3T4P8	Cafeteria_roenbergensis_virus	5.1e-26	27.7
WP_014096718.1\|154321_154840_+	hypothetical protein	NA	NA	NA	NA
WP_071646869.1\|154854_155070_-	4-oxalocrotonate tautomerase	NA	NA	NA	NA
WP_026685123.1\|155185_155848_+\|protease	site-2 protease family protein	NA	NA	NA	NA

DBSCAN-SWA_3

369379 : 377692

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_017550741.1\|369379_370675_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	6.5e-18	32.8
WP_026684440.1\|370763_371474_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SS43	Cyanophage	7.4e-48	42.8
WP_026684441.1\|371466_371721_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_026684442.1\|371717_372401_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_026684443.1\|372384_374634_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	7.8e-168	44.1
WP_026684444.1\|374618_376043_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	4.6e-49	33.1
WP_026684445.1\|376062_377106_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	8.6e-61	45.6
WP_026684446.1\|377098_377692_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.4e-29	40.3

DBSCAN-SWA_4

395416 : 447873

Catovirus(20.0%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014096920.1\|395416_395707_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_035183337.1\|395719_397177_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_014096922.1\|397189_398623_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_013860577.1\|398725_398932_+	hypothetical protein	NA	NA	NA	NA
WP_035183339.1\|399168_399555_-	general stress protein	NA	NA	NA	NA
WP_014096925.1\|401952_402753_+	arylamine N-acetyltransferase	NA	NA	NA	NA
WP_014096926.1\|403098_404013_+	diacylglycerol kinase	A0A1V0SBJ0	Catovirus	3.9e-25	29.6
WP_035183348.1\|404452_405910_-	sodium/proline symporter PutP	NA	NA	NA	NA
WP_014096928.1\|406122_407496_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	6.5e-125	49.0
WP_014096929.1\|408782_409805_+	hypothetical protein	NA	NA	NA	NA
WP_013860569.1\|410026_410533_-	RNA-binding protein S4	NA	NA	NA	NA
WP_017550765.1\|410717_411254_-	cysteine hydrolase	NA	NA	NA	NA
WP_014096932.1\|411268_411472_-	hypothetical protein	NA	NA	NA	NA
WP_013860568.1\|411727_411952_+	hypothetical protein	NA	NA	NA	NA
WP_013858393.1\|415026_416250_-\|transposase	IS110 family transposase	M1NSC9	Streptococcus_phage	3.7e-79	46.5
WP_014096937.1\|416660_417101_+	PTS fructose transporter subunit IIA	NA	NA	NA	NA
WP_014095824.1\|417605_418916_-\|transposase	transposase family protein	NA	NA	NA	NA
WP_014096939.1\|419333_420134_+	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_014096940.1\|420130_420952_+	PTS system mannose/fructose/sorbose family transporter subunit IID	NA	NA	NA	NA
WP_014096941.1\|420974_421652_+	hypothetical protein	NA	NA	NA	NA
WP_013858128.1\|421837_423148_+\|transposase	transposase family protein	NA	NA	NA	NA
WP_014096943.1\|423322_424942_+	hypothetical protein	NA	NA	NA	NA
WP_014096944.1\|425079_425478_+	DUF2961 domain-containing protein	NA	NA	NA	NA
WP_014096945.1\|425589_427275_-\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_014096946.1\|427357_428062_+	DUF2961 domain-containing protein	NA	NA	NA	NA
WP_014096947.1\|428332_429163_-	DUF1835 domain-containing protein	NA	NA	NA	NA
WP_014096948.1\|429684_430458_-	acetoin reductase	NA	NA	NA	NA
WP_035183368.1\|430820_431984_-	MFS transporter	NA	NA	NA	NA
WP_017551570.1\|432152_433055_+	Rgg/GadR/MutR family transcriptional regulator	NA	NA	NA	NA
WP_017551571.1\|433232_433607_+	DUF2750 domain-containing protein	NA	NA	NA	NA
WP_017551572.1\|434284_435070_-	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	2.5e-20	32.4
WP_017551575.1\|436353_436719_-	hypothetical protein	NA	NA	NA	NA
WP_035183363.1\|436918_437941_+	alcohol dehydrogenase AdhP	A0A2K9L339	Tupanvirus	6.3e-24	23.9
WP_035183364.1\|438867_439989_+	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_035183366.1\|440032_440638_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_014095824.1\|441203_442514_+\|transposase	transposase family protein	NA	NA	NA	NA
WP_035185348.1\|442841_443705_-	hypothetical protein	NA	NA	NA	NA
WP_052042185.1\|443688_444495_-	hypothetical protein	NA	NA	NA	NA
WP_048339785.1\|444500_444869_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014095824.1\|446562_447873_-\|transposase	transposase family protein	NA	NA	NA	NA

DBSCAN-SWA_5

542110 : 598707

Streptococcus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014097043.1\|542110_543100_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_017550090.1\|543101_543365_+	hypothetical protein	NA	NA	NA	NA
WP_014097045.1\|543563_544052_+	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_014097049.1\|545677_545830_+	hypothetical protein	NA	NA	NA	NA
WP_035183435.1\|546216_547194_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_014097051.1\|547196_548078_+	ribokinase	NA	NA	NA	NA
WP_035183437.1\|548077_548470_+	D-ribose pyranase	NA	NA	NA	NA
WP_014097053.1\|548516_550016_+	sugar ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.1e-11	24.8
WP_035183438.1\|549999_550944_+	ribose ABC transporter permease	NA	NA	NA	NA
WP_035183439.1\|550959_551880_+	ribose ABC transporter substrate-binding protein RbsB	NA	NA	NA	NA
WP_035183440.1\|552737_554033_+	GntP family permease	NA	NA	NA	NA
WP_035183442.1\|554045_555191_+	glycerate kinase	W6LM47	Streptococcus_phage	1.0e-46	39.6
WP_052042148.1\|555430_556456_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_035183443.1\|556904_557954_+	2,3-butanediol dehydrogenase	NA	NA	NA	NA
WP_035183444.1\|558088_559168_+	hypothetical protein	NA	NA	NA	NA
WP_035183445.1\|559946_561818_+	anaerobic ribonucleoside triphosphate reductase	A0A0A8WEK0	Clostridium_phage	6.5e-160	45.8
WP_035183446.1\|561814_562291_+	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A0A8WJI9	Clostridium_phage	1.9e-36	49.0
WP_035183448.1\|563384_564641_+	cation:dicarboxylase symporter family transporter	NA	NA	NA	NA
WP_035183449.1\|564940_565690_+	glucose 1-dehydrogenase	A0A0N9R355	Chrysochromulina_ericina_virus	3.9e-15	28.9
WP_017551449.1\|565914_567090_-\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	3.6e-84	42.6
WP_035183461.1\|567879_568776_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_035183453.1\|569031_570678_+	NAD-dependent malic enzyme	NA	NA	NA	NA
WP_035183455.1\|572296_573040_+	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_035183457.1\|573437_575045_+	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_035183458.1\|575067_576393_+	6-phospho-alpha-glucosidase	NA	NA	NA	NA
WP_043052472.1\|576821_578183_+\|transposase	transposase	NA	NA	NA	NA
WP_017551180.1\|578388_578877_+	PTS glucose transporter subunit IIA	NA	NA	NA	NA
WP_017551179.1\|579149_579623_-	glutathione peroxidase	NA	NA	NA	NA
WP_035183467.1\|580953_582285_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_035183470.1\|582274_582559_-	glutaredoxin family protein	NA	NA	NA	NA
WP_035183472.1\|582560_583592_-	MsnO8 family LLM class oxidoreductase	NA	NA	NA	NA
WP_035183474.1\|583607_584363_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.7e-34	41.0
WP_035183477.1\|584359_585067_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_026104591.1\|585079_585799_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_017551171.1\|585813_586611_-	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_017551170.1\|586626_587427_-	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_035183480.1\|587423_587990_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_035183483.1\|588004_588559_-	NADPH-dependent FMN reductase	NA	NA	NA	NA
WP_100183701.1\|588705_589659_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_043052461.1\|590041_591562_+\|transposase	IS5-like element ISBco3 family transposase	NA	NA	NA	NA
WP_017551166.1\|591635_592637_+	cysteine synthase family protein	A0A1X9I5F1	Streptococcus_phage	2.0e-54	40.6
WP_017551165.1\|592846_593044_+	hypothetical protein	NA	NA	NA	NA
WP_017551163.1\|593463_593913_+	hypothetical protein	NA	NA	NA	NA
WP_043052461.1\|594445_595966_+\|transposase	IS5-like element ISBco3 family transposase	NA	NA	NA	NA
WP_017550355.1\|597393_598707_+\|transposase	IS1380-like element ISBco1 family transposase	A0A1X9I6F6	Streptococcus_phage	7.1e-113	48.8

DBSCAN-SWA_6

855024 : 934245

Streptococcus_phage(11.11%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013858393.1\|855024_856248_-\|transposase	IS110 family transposase	M1NSC9	Streptococcus_phage	3.7e-79	46.5
WP_035183866.1\|856658_856976_+	YfhH family protein	NA	NA	NA	NA
WP_026684724.1\|859662_860781_-	A/G-specific adenine glycosylase	NA	NA	NA	NA
WP_014097361.1\|860959_861940_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_014097362.1\|862026_862185_+	small, acid-soluble spore protein K	NA	NA	NA	NA
WP_035183873.1\|862515_863388_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.4e-19	32.3
WP_043052472.1\|863350_864712_-\|transposase	transposase	NA	NA	NA	NA
WP_035183880.1\|865579_865864_+	hypothetical protein	NA	NA	NA	NA
WP_014097366.1\|865993_867451_-	glutamate synthase subunit beta	NA	NA	NA	NA
WP_035183882.1\|867729_872292_-	glutamate synthase large subunit	NA	NA	NA	NA
WP_014097368.1\|872416_873331_+	LysR family transcriptional regulator	Q6JIH3	Burkholderia_virus	4.8e-07	28.4
WP_014097369.1\|873613_874363_+	enoyl-[acyl-carrier-protein] reductase FabL	NA	NA	NA	NA
WP_014097370.1\|874458_874689_+	gamma-type small acid-soluble spore protein	NA	NA	NA	NA
WP_014097371.1\|874835_875090_+	hypothetical protein	NA	NA	NA	NA
WP_014097372.1\|875244_875775_+	DUF402 domain-containing protein	NA	NA	NA	NA
WP_014097373.1\|875875_877624_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.2e-54	32.2
WP_035183885.1\|877955_879035_+	DUF871 domain-containing protein	NA	NA	NA	NA
WP_035183889.1\|879025_879913_+	N-acetylmuramic acid 6-phosphate etherase	NA	NA	NA	NA
WP_014097376.1\|879930_881400_+	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_035183891.1\|881399_882269_+	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_014097379.1\|883741_884020_+	YqhV family protein	NA	NA	NA	NA
WP_035183893.1\|884270_884651_-	hypothetical protein	NA	NA	NA	NA
WP_035183895.1\|884784_886053_+	MFS transporter	NA	NA	NA	NA
WP_014097382.1\|886157_886799_-	YitT family protein	NA	NA	NA	NA
WP_014097383.1\|887313_888102_-	ATP-binding cassette domain-containing protein	G3M9Y6	Bacillus_virus	2.0e-33	38.3
WP_014097384.1\|888118_888901_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_026684815.1\|888897_889923_-	sulfonate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_017551390.1\|890608_891901_-	glutamate-1-semialdehyde 2,1-aminomutase	NA	NA	NA	NA
WP_014097387.1\|892044_892449_+	two pore domain potassium channel family protein	NA	NA	NA	NA
WP_017551388.1\|892758_893313_+	cob(I)yrinic acid a,c-diamide adenosyltransferase	NA	NA	NA	NA
WP_014097390.1\|893524_893974_+	peroxide-responsive transcriptional repressor PerR	NA	NA	NA	NA
WP_014097391.1\|894168_895056_-	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	2.5e-08	24.2
WP_035183899.1\|895249_896938_+	acetolactate synthase AlsS	NA	NA	NA	NA
WP_017551385.1\|897023_897773_+	acetolactate decarboxylase	NA	NA	NA	NA
WP_035183901.1\|897884_898244_-	YgzB family protein	NA	NA	NA	NA
WP_017551383.1\|898382_899255_+	hypothetical protein	NA	NA	NA	NA
WP_017550137.1\|906770_907790_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_017550136.1\|908376_909504_+	zinc-binding dehydrogenase	NA	NA	NA	NA
WP_017550135.1\|909914_910799_+	DMT family transporter	NA	NA	NA	NA
WP_061577275.1\|910927_911200_+	hypothetical protein	NA	NA	NA	NA
WP_035183911.1\|911546_912932_+	MFS transporter	NA	NA	NA	NA
WP_035183913.1\|913053_914280_+	MFS transporter	NA	NA	NA	NA
WP_080738167.1\|914758_914893_+	hypothetical protein	NA	NA	NA	NA
WP_035183915.1\|915001_917248_+	DUF1430 domain-containing protein	NA	NA	NA	NA
WP_043052479.1\|917473_918889_+\|transposase	ISLre2-like element ISBco6 family transposase	NA	NA	NA	NA
WP_061466630.1\|919191_919725_+	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	2.6e-21	38.0
WP_035185129.1\|920078_920561_+	DUF2243 domain-containing protein	NA	NA	NA	NA
WP_035185124.1\|920569_921385_+	cytochrome c oxidase assembly protein	NA	NA	NA	NA
WP_082188820.1\|921761_923099_-\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_035183918.1\|923244_923709_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_035183920.1\|925668_926172_-	hypothetical protein	NA	NA	NA	NA
WP_043052461.1\|926444_927965_+\|transposase	IS5-like element ISBco3 family transposase	NA	NA	NA	NA
WP_080738183.1\|927980_928586_-	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	1.5e-09	30.3
WP_052042183.1\|928575_928767_-	ATP-binding cassette domain-containing protein	NA	NA	NA	NA
WP_088775936.1\|929139_930267_-	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_035185271.1\|930292_931804_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	1.2e-76	40.2
WP_035185274.1\|931936_932659_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_014095824.1\|932934_934245_-\|transposase	transposase family protein	NA	NA	NA	NA

DBSCAN-SWA_7

1356301 : 1405965

Staphylococcus_phage(20.0%)

protease,coat,transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_043052491.1\|1356301_1357525_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_014097792.1\|1358088_1359450_+\|transposase	transposase	NA	NA	NA	NA
WP_035184435.1\|1359451_1359877_+	hypothetical protein	NA	NA	NA	NA
WP_014097794.1\|1359903_1360116_-	small acid-soluble spore protein SspI	NA	NA	NA	NA
WP_035184438.1\|1360220_1360976_+	RNA methyltransferase	NA	NA	NA	NA
WP_035184439.1\|1361621_1362659_+\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2I2L4E3	Orpheovirus	5.4e-31	33.1
WP_035184441.1\|1362671_1365086_+\|tRNA	phenylalanine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_035184443.1\|1365478_1366414_-	ribonuclease HIII	NA	NA	NA	NA
WP_013859878.1\|1366514_1366805_+	cell division protein ZapA	NA	NA	NA	NA
WP_080738175.1\|1366791_1367328_+	CvpA family protein	NA	NA	NA	NA
WP_035184447.1\|1367606_1369325_+	DNA polymerase/3'-5' exonuclease PolX	A0A0N9R450	Chrysochromulina_ericina_virus	2.6e-14	26.2
WP_014097802.1\|1369400_1371755_+	endonuclease MutS2	Q94M10	Lactobacillus_phage	2.6e-20	49.6
WP_014097803.1\|1371991_1373689_+	AMP-binding protein	A0A2H4PQM9	Staphylococcus_phage	2.5e-41	27.7
WP_014097804.1\|1373831_1374425_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_035184449.1\|1374458_1375232_+	enoyl-CoA hydratase	NA	NA	NA	NA
WP_035184451.1\|1375294_1376068_+	electron transfer flavoprotein subunit beta/FixA family protein	NA	NA	NA	NA
WP_035184453.1\|1376098_1377079_+	electron transfer flavoprotein subunit alpha/FixB family protein	NA	NA	NA	NA
WP_043052479.1\|1377295_1378711_+\|transposase	ISLre2-like element ISBco6 family transposase	NA	NA	NA	NA
WP_014097808.1\|1379096_1379411_+	thioredoxin	A0A1X9I9P5	Staphylococcus_phage	2.6e-21	42.7
WP_035184458.1\|1379516_1381289_+	excinuclease ABC subunit UvrC	NA	NA	NA	NA
WP_035184460.1\|1381706_1382936_+	aspartate kinase	NA	NA	NA	NA
WP_014097811.1\|1382969_1383434_-	YslB family protein	NA	NA	NA	NA
WP_035184462.1\|1383862_1384471_+	succinate dehydrogenase cytochrome b558 subunit	NA	NA	NA	NA
WP_017551099.1\|1384542_1386294_+	succinate dehydrogenase flavoprotein subunit	NA	NA	NA	NA
WP_014097814.1\|1386366_1387134_+	succinate dehydrogenase iron-sulfur subunit	NA	NA	NA	NA
WP_043052492.1\|1387198_1387708_+	acyl-CoA thioesterase	NA	NA	NA	NA
WP_014097816.1\|1388067_1388292_+	response regulator transcription factor	A0A290GJH9	Caldibacillus_phage	6.1e-17	77.0
WP_035184465.1\|1388577_1388763_+	hypothetical protein	NA	NA	NA	NA
WP_026684041.1\|1389029_1389329_+	DUF1648 domain-containing protein	NA	NA	NA	NA
WP_014097818.1\|1389341_1390430_+	DUF2157 domain-containing protein	NA	NA	NA	NA
WP_035184467.1\|1390422_1390947_+	GDYXXLXY domain-containing protein	NA	NA	NA	NA
WP_035184469.1\|1391388_1391841_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_017551093.1\|1391851_1392661_+	glutamate racemase	NA	NA	NA	NA
WP_014097822.1\|1392752_1392968_+	hypothetical protein	NA	NA	NA	NA
WP_014097823.1\|1392964_1393333_+\|coat	spore coat protein	NA	NA	NA	NA
WP_017551092.1\|1393342_1394479_+	glutathione-dependent formaldehyde dehydrogenase	E3SJ82	Synechococcus_phage	3.2e-13	29.8
WP_014097825.1\|1394625_1394928_-\|coat	spore coat protein	NA	NA	NA	NA
WP_014097826.1\|1394924_1395125_-	hypothetical protein	NA	NA	NA	NA
WP_014097827.1\|1395268_1396309_+	GerMN domain-containing protein	NA	NA	NA	NA
WP_014097828.1\|1396416_1397025_+	XTP/dITP diphosphatase	A0A2H4UUV7	Bodo_saltans_virus	8.1e-11	33.3
WP_014097829.1\|1397021_1397531_+	metallophosphoesterase	NA	NA	NA	NA
WP_035184472.1\|1398334_1398736_+	hypothetical protein	NA	NA	NA	NA
WP_014097831.1\|1398974_1399271_-	hypothetical protein	NA	NA	NA	NA
WP_014097832.1\|1399405_1399849_+	YndM family protein	NA	NA	NA	NA
WP_043052493.1\|1400301_1401711_+	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	2.0e-36	30.5
WP_014097833.1\|1401885_1402878_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_014097834.1\|1403041_1404328_+	trigger factor	NA	NA	NA	NA
WP_014097835.1\|1404696_1405965_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	5.4e-150	67.4

DBSCAN-SWA_8

1754281 : 1820755

Bacillus_phage(29.41%)

tail,tRNA,head,terminase,portal,capsid,holin,integrase,protease

attL 1782858:1782917|attR 1818665:1818763

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_035184709.1\|1754281_1755574_+\|tRNA	asparagine--tRNA ligase	M1PB22	Moumouvirus	2.7e-56	30.8
WP_043052469.1\|1755659_1757069_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	2.0e-36	30.5
WP_014098190.1\|1757578_1758274_+	DnaD domain-containing protein	A0A0N7AE27	Bacillus_phage	2.3e-25	48.7
WP_014098191.1\|1758321_1758981_+	endonuclease III	NA	NA	NA	NA
WP_035184715.1\|1759068_1761804_-	PBP1A family penicillin-binding protein	NA	NA	NA	NA
WP_014098194.1\|1761896_1762502_-	Holliday junction resolvase RecU	NA	NA	NA	NA
WP_014098196.1\|1763058_1763298_+	hypothetical protein	NA	NA	NA	NA
WP_014098197.1\|1763365_1763728_+	YppE family protein	NA	NA	NA	NA
WP_014098198.1\|1763799_1764294_+	hypothetical protein	NA	NA	NA	NA
WP_014098199.1\|1764359_1764803_-	Hsp20/alpha crystallin family protein	NA	NA	NA	NA
WP_035184719.1\|1764952_1767253_+	DEAD/DEAH box helicase	A0A1B1IUF6	uncultured_Mediterranean_phage	1.5e-09	32.5
WP_014098201.1\|1767233_1768532_+	ribonuclease H-like domain-containing protein	NA	NA	NA	NA
WP_014098202.1\|1768870_1769122_+	hypothetical protein	NA	NA	NA	NA
WP_014098203.1\|1769191_1769743_+	DUF1273 domain-containing protein	NA	NA	NA	NA
WP_013859462.1\|1769823_1770126_+	cell division regulator GpsB	NA	NA	NA	NA
WP_014098204.1\|1770855_1772001_+	class I SAM-dependent RNA methyltransferase	NA	NA	NA	NA
WP_172653411.1\|1772076_1773603_+	carboxypeptidase M32	NA	NA	NA	NA
WP_014098206.1\|1774149_1774737_+	xanthine phosphoribosyltransferase	NA	NA	NA	NA
WP_014098207.1\|1774733_1776047_+	purine permease	NA	NA	NA	NA
WP_014098209.1\|1777056_1777260_-	hypothetical protein	NA	NA	NA	NA
WP_017550446.1\|1777425_1781025_+	dynamin family protein	NA	NA	NA	NA
WP_014098211.1\|1781117_1781507_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_014098212.1\|1781576_1782914_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
1782858:1782917	attL	NA	NA	NA	NA
WP_172653412.1\|1783022_1784156_-\|integrase	site-specific integrase	A0A0S2SXP1	Bacillus_phage	2.0e-71	71.9
WP_035184723.1\|1784198_1784708_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_035184725.1\|1784812_1785079_-	hypothetical protein	NA	NA	NA	NA
WP_035184727.1\|1785082_1787083_-	DEAD/DEAH box helicase family protein	Q5YA94	Bacillus_phage	1.3e-20	32.5
WP_052042163.1\|1787128_1788091_-	3'-5' exoribonuclease	A0A0A8WJ41	Clostridium_phage	1.9e-30	39.2
WP_035184729.1\|1788120_1789038_-	NAD-dependent DNA ligase	NA	NA	NA	NA
WP_035184731.1\|1789166_1789586_-	helix-turn-helix transcriptional regulator	A0A1B1P888	Bacillus_phage	3.0e-09	51.7
WP_035184732.1\|1789731_1789959_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_035184735.1\|1790247_1790769_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_035184739.1\|1790793_1791063_+	group-specific protein	A0A1B1P7U4	Bacillus_phage	3.5e-27	62.8
WP_043052499.1\|1791075_1791357_+	hypothetical protein	NA	NA	NA	NA
WP_035184741.1\|1791443_1791635_+	hypothetical protein	NA	NA	NA	NA
WP_035184742.1\|1791798_1792164_+	hypothetical protein	S6BFM8	Thermus_phage	1.7e-08	32.4
WP_035184743.1\|1792176_1793139_+	DnaD domain protein	A0A0U4JX08	Bacillus_phage	1.6e-37	60.3
WP_080738177.1\|1793135_1793528_+	single-stranded DNA-binding protein	A0A290GHL8	Caldibacillus_phage	2.0e-39	60.0
WP_035184744.1\|1793722_1793932_+	hypothetical protein	NA	NA	NA	NA
WP_035184746.1\|1794064_1794253_+	BH0509 family protein	NA	NA	NA	NA
WP_035184748.1\|1794521_1794704_+	hypothetical protein	NA	NA	NA	NA
WP_035184750.1\|1794718_1795021_+	hypothetical protein	NA	NA	NA	NA
WP_035184753.1\|1795026_1795227_+	hypothetical protein	NA	NA	NA	NA
WP_035184755.1\|1795244_1795484_+	hypothetical protein	NA	NA	NA	NA
WP_035184757.1\|1795546_1796233_+	phage antirepressor KilAC domain-containing protein	A0A2P1JTZ2	Anoxybacillus_phage	4.8e-36	39.1
WP_035184760.1\|1796335_1796791_+	ArpU family transcriptional regulator	S6AVV9	Thermus_phage	1.5e-38	54.9
WP_035184762.1\|1796787_1797330_+\|integrase	site-specific integrase	D2XR58	Bacillus_phage	8.7e-57	60.6
WP_035184764.1\|1797491_1797791_+	hypothetical protein	NA	NA	NA	NA
WP_035184766.1\|1798114_1798333_+	hypothetical protein	NA	NA	NA	NA
WP_035184768.1\|1798338_1798710_+	HNH endonuclease	A0A1U7Q1S7	Geobacillus_virus	1.5e-31	52.3
WP_035184770.1\|1798817_1799354_+	hypothetical protein	A0A2I7SBY3	Paenibacillus_phage	1.1e-16	34.3
WP_088775930.1\|1799343_1800912_+\|terminase	terminase large subunit	A0A2I7SBY8	Paenibacillus_phage	2.6e-247	74.7
WP_035184772.1\|1800930_1802217_+\|portal	phage portal protein	Q0SPK2	Clostridium_phage	7.4e-131	54.3
WP_035184773.1\|1802203_1802920_+\|protease	Clp protease ClpP	A0A2I7SCY8	Paenibacillus_phage	2.8e-55	54.1
WP_052042165.1\|1802934_1804083_+\|capsid	phage major capsid protein	A0A0A7S154	Clostridium_phage	9.4e-77	43.2
WP_035184775.1\|1804096_1804381_+\|head,tail	phage gp6-like head-tail connector protein	A6M953	Geobacillus_virus	6.6e-24	61.4
WP_035184777.1\|1804383_1804716_+\|head	phage head closure protein	NA	NA	NA	NA
WP_035184779.1\|1804715_1805147_+	HK97 gp10 family phage protein	A0A1B1P9Z7	Enterococcus_phage	4.8e-10	33.3
WP_035184781.1\|1805143_1805530_+	hypothetical protein	NA	NA	NA	NA
WP_035184783.1\|1805542_1806151_+	hypothetical protein	NA	NA	NA	NA
WP_035184785.1\|1806204_1806531_+	hypothetical protein	NA	NA	NA	NA
WP_052498231.1\|1806699_1810878_+\|tail	phage tail tape measure protein	A8ATA7	Listeria_phage	9.9e-92	37.0
WP_035184787.1\|1810885_1811710_+\|tail	phage tail family protein	A8ATA8	Listeria_phage	8.9e-29	33.2
WP_052042168.1\|1811718_1813125_+\|tail	phage tail protein	Q9T1A5	Listeria_phage	7.7e-73	41.4
WP_052042170.1\|1813124_1814594_+	metallophosphoesterase	A0A0U4JVA9	Exiguobacterium_phage	4.5e-15	43.4
WP_035184789.1\|1814603_1815332_+	hypothetical protein	A0A2P0ZL22	Lactobacillus_phage	4.8e-34	38.2
WP_035184791.1\|1815347_1815638_+	hypothetical protein	NA	NA	NA	NA
WP_164931350.1\|1815640_1815808_+	hypothetical protein	I1TLF8	Bacillus_phage	4.0e-05	52.3
WP_035184794.1\|1815878_1816133_+	hypothetical protein	A0A2H4J8H2	uncultured_Caudovirales_phage	5.5e-06	41.5
WP_035184860.1\|1816266_1816524_+	hemolysin XhlA family protein	NA	NA	NA	NA
WP_172653413.1\|1816535_1816775_+\|holin	phage holin	M4ZR48	Bacillus_phage	1.0e-22	67.1
WP_052042174.1\|1816829_1817669_+	N-acetylmuramoyl-L-alanine amidase	Q5ILA1	Bacillus_phage	4.8e-14	29.8
WP_035184796.1\|1817773_1818490_-	hypothetical protein	NA	NA	NA	NA
WP_014098213.1\|1818939_1819560_-	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	2.5e-15	62.3
1818665:1818763	attR	NA	NA	NA	NA
WP_014098214.1\|1819766_1820105_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_014098215.1\|1820101_1820755_+	recombinase family protein	D7RWL2	Brochothrix_phage	3.2e-05	25.3

DBSCAN-SWA_9

2622120 : 2628302

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_035182139.1\|2622120_2622705_+	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	1.3e-53	56.0
WP_014095819.1\|2622791_2623061_-	HPr family phosphocarrier protein	NA	NA	NA	NA
WP_013858691.1\|2623171_2624125_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	9.2e-54	39.1
WP_017551710.1\|2624205_2625186_-	YvcK family protein	A1IMD5	Streptococcus_phage	1.2e-67	44.6
WP_017551709.1\|2625182_2626073_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	4.3e-05	29.8
WP_014095823.1\|2626109_2626568_-	8-oxo-dGTP diphosphatase	K4F7D9	Cronobacter_phage	6.9e-07	33.3
WP_017551707.1\|2627354_2628302_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	4.1e-86	53.1

DBSCAN-SWA_10

3317947 : 3358709

Streptococcus_phage(42.86%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_017551449.1\|3317947_3319123_+\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	3.6e-84	42.6
WP_014096394.1\|3320092_3320314_-	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_035182737.1\|3320335_3322279_-	cation-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.9e-109	38.8
WP_035182739.1\|3322481_3323234_-	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_052042116.1\|3323478_3324564_-	excinuclease ABC subunit C	NA	NA	NA	NA
WP_014096398.1\|3324560_3325022_-	flavodoxin	NA	NA	NA	NA
WP_035182744.1\|3325788_3326697_+	decarboxylating 6-phosphogluconate dehydrogenase	M1T2E7	Synechococcus_phage	6.7e-54	36.1
WP_017550602.1\|3326757_3327450_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_035182746.1\|3327600_3329157_+	gluconokinase	NA	NA	NA	NA
WP_014096403.1\|3329558_3330887_+	2-keto-3-deoxygluconate permease	NA	NA	NA	NA
WP_014096404.1\|3330980_3331700_-	trehalose operon repressor	NA	NA	NA	NA
WP_014096405.1\|3331740_3333417_-	alpha,alpha-phosphotrehalase	NA	NA	NA	NA
WP_035182749.1\|3333545_3334964_-	PTS system trehalose-specific EIIBC component	NA	NA	NA	NA
WP_014096407.1\|3334994_3335477_-	PTS glucose transporter subunit IIA	NA	NA	NA	NA
WP_014096408.1\|3336009_3337539_-	ABC transporter permease/substrate-binding protein	NA	NA	NA	NA
WP_043052528.1\|3337531_3338488_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.6e-24	33.2
WP_017551449.1\|3339264_3340440_-\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	3.6e-84	42.6
WP_035182760.1\|3343270_3344248_-	D-glycerate dehydrogenase	M1NSB9	Streptococcus_phage	2.6e-19	28.2
WP_035182763.1\|3344410_3344869_+	hypothetical protein	NA	NA	NA	NA
WP_014096413.1\|3344998_3345337_+	DsrE family protein	NA	NA	NA	NA
WP_014096414.1\|3345573_3346752_-	acetyl-CoA C-acetyltransferase	NA	NA	NA	NA
WP_043052495.1\|3347199_3348615_-\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_043052529.1\|3349012_3350698_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_014096420.1\|3351253_3351490_+	hypothetical protein	A0A2I6QQV7	Streptococcus_phage	6.1e-07	69.0
WP_014096421.1\|3351560_3352301_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_014096422.1\|3352496_3353288_-	DUF2837 family protein	NA	NA	NA	NA
WP_014096423.1\|3353500_3353941_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014096424.1\|3354138_3355407_-	MFS transporter	NA	NA	NA	NA
WP_017550280.1\|3355619_3356240_-	hypothetical protein	NA	NA	NA	NA
WP_014096426.1\|3356564_3356711_+	hypothetical protein	NA	NA	NA	NA
WP_014095824.1\|3357398_3358709_-\|transposase	transposase family protein	NA	NA	NA	NA

DBSCAN-SWA_11

3384805 : 3446176

Bacillus_phage(17.14%)

tail,integrase,terminase,transposase

attL 3407740:3407788|attR 3446262:3446310

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014095824.1\|3384805_3386116_+\|transposase	transposase family protein	NA	NA	NA	NA
WP_048339794.1\|3386419_3386824_+	glycine-rich domain-containing protein-like	A0A2I2L429	Orpheovirus	9.4e-08	34.7
WP_082188825.1\|3387031_3388369_-\|transposase	IS1380 family transposase	NA	NA	NA	NA
WP_035182800.1\|3388450_3388735_+	hypothetical protein	NA	NA	NA	NA
WP_014096450.1\|3388827_3390039_+	MFS transporter	NA	NA	NA	NA
WP_014095824.1\|3390578_3391889_-\|transposase	transposase family protein	NA	NA	NA	NA
WP_035182807.1\|3393835_3394762_+	oxidoreductase	NA	NA	NA	NA
WP_035182809.1\|3394758_3395622_+	hypothetical protein	NA	NA	NA	NA
WP_035182811.1\|3395816_3396569_-	acyl-ACP thioesterase	NA	NA	NA	NA
WP_026683804.1\|3396764_3397280_-	ClbS/DfsB family four-helix bundle protein	NA	NA	NA	NA
WP_026683805.1\|3397372_3397798_-	hypothetical protein	NA	NA	NA	NA
WP_035182814.1\|3399003_3400806_-	glutamine--fructose-6-phosphate transaminase (isomerizing)	Q84421	Paramecium_bursaria_Chlorella_virus	3.2e-108	39.6
WP_014096454.1\|3401270_3402623_-	phosphoglucosamine mutase	NA	NA	NA	NA
WP_014096455.1\|3402659_3403910_-	hypothetical protein	NA	NA	NA	NA
WP_014096456.1\|3403902_3404730_-	TIGR00159 family protein	NA	NA	NA	NA
WP_014096457.1\|3404876_3405491_-	anti-sigma factor	NA	NA	NA	NA
WP_014096458.1\|3405503_3406067_-	RNA polymerase sigma factor SigW	NA	NA	NA	NA
WP_014096459.1\|3406242_3406416_+	aspartyl-phosphate phosphatase Spo0E family protein	NA	NA	NA	NA
WP_014096460.1\|3406520_3407420_-	arginase	A0A1V0SJM8	Klosneuvirus	2.1e-23	32.0
3407740:3407788	attL	NA	NA	NA	NA
WP_048339792.1\|3408235_3409522_-	LysM peptidoglycan-binding domain-containing protein	V5UQT2	Oenococcus_phage	1.4e-28	29.8
WP_080738157.1\|3409939_3410146_-	hemolysin XhlA family protein	NA	NA	NA	NA
WP_035182826.1\|3410358_3411183_-	SGNH/GDSL hydrolase family protein	A0A2H4J9Z4	uncultured_Caudovirales_phage	3.0e-24	33.5
WP_035182828.1\|3411277_3411541_-	hypothetical protein	NA	NA	NA	NA
WP_035182831.1\|3411552_3413058_-	hypothetical protein	M4M9L1	Vibrio_phage	3.4e-34	30.7
WP_035182834.1\|3413057_3413411_-	hypothetical protein	A0A142KA97	Gordonia_phage	1.4e-07	61.2
WP_052042118.1\|3413403_3414510_-\|tail	phage tail protein	A6M966	Geobacillus_virus	8.0e-41	32.2
WP_043052531.1\|3414519_3415365_-\|tail	phage tail family protein	A6M962	Geobacillus_virus	1.5e-55	44.6
WP_167336723.1\|3415361_3416822_-	transglycosylase SLT domain-containing protein	A0A182BQ85	Lactococcus_phage	4.0e-72	51.9
WP_142743400.1\|3418504_3418798_-	hypothetical protein	NA	NA	NA	NA
WP_035182840.1\|3418860_3419265_-	hypothetical protein	NA	NA	NA	NA
WP_035182843.1\|3419278_3420094_-	hypothetical protein	A0A1B1P7D9	Bacillus_phage	5.9e-49	41.2
WP_035182846.1\|3420105_3420465_-	hypothetical protein	A0A1B1P7D3	Bacillus_phage	5.1e-21	40.7
WP_052042122.1\|3420477_3420882_-	HK97 gp10 family phage protein	A0A1B1P7D0	Bacillus_phage	5.9e-10	33.3
WP_035182847.1\|3420883_3421240_-	hypothetical protein	NA	NA	NA	NA
WP_035182849.1\|3421236_3421647_-	DUF3199 family protein	NA	NA	NA	NA
WP_155375943.1\|3421648_3421819_-	hypothetical protein	NA	NA	NA	NA
WP_035182850.1\|3421831_3422914_-	hypothetical protein	NA	NA	NA	NA
WP_035182852.1\|3422929_3423316_-	hypothetical protein	NA	NA	NA	NA
WP_035182854.1\|3423315_3424506_-	hypothetical protein	NA	NA	NA	NA
WP_052042124.1\|3424506_3426789_-	hypothetical protein	M4R217	Salicola_phage	2.0e-09	38.5
WP_048339823.1\|3426794_3428246_-\|terminase	phage terminase large subunit	A8ATG0	Listeria_phage	3.1e-162	60.3
WP_035182859.1\|3428235_3428820_-	hypothetical protein	A0A1S5SAK3	Streptococcus_phage	3.6e-48	53.7
WP_035182861.1\|3429012_3429444_-	hypothetical protein	A0A2H4J4R7	uncultured_Caudovirales_phage	2.6e-16	34.6
WP_035182863.1\|3429440_3429647_-	hypothetical protein	NA	NA	NA	NA
WP_155375944.1\|3429776_3429935_-	hypothetical protein	NA	NA	NA	NA
WP_155375945.1\|3429972_3430134_-	hypothetical protein	NA	NA	NA	NA
WP_035182866.1\|3430173_3430629_-	methyltransferase domain-containing protein	A0A059T693	Listeria_phage	1.4e-60	69.3
WP_071646876.1\|3430862_3431021_-	DUF3954 domain-containing protein	A0A2P1JTX5	Anoxybacillus_phage	5.5e-12	61.5
WP_052498234.1\|3431120_3431819_-	N-6 DNA methylase	H7BVT3	unidentified_phage	2.1e-18	40.5
WP_172653418.1\|3431827_3431998_-	hypothetical protein	NA	NA	NA	NA
WP_043052534.1\|3432273_3432735_-	DUF1064 domain-containing protein	A0A2P1JTY5	Anoxybacillus_phage	8.7e-58	79.3
WP_035182875.1\|3432744_3433377_-	dUTP diphosphatase	A0A290GJJ6	Caldibacillus_phage	1.7e-43	47.2
WP_035182878.1\|3433373_3433571_-	hypothetical protein	NA	NA	NA	NA
WP_155375946.1\|3433735_3433912_-	hypothetical protein	NA	NA	NA	NA
WP_052042126.1\|3433908_3435225_-	replicative DNA helicase	D2XR44	Bacillus_phage	1.1e-94	45.0
WP_043052535.1\|3435181_3435502_-	hypothetical protein	NA	NA	NA	NA
WP_052042127.1\|3435498_3436335_-	DUF4373 domain-containing protein	A0A0H4TKJ7	Bacillus_phage	4.5e-12	33.8
WP_035182880.1\|3436392_3437289_-	recombinase RecT	A0A0B5CTU3	Listeria_phage	1.3e-94	70.6
WP_088775933.1\|3437288_3438236_-	YqaJ viral recombinase family protein	A8ATY5	Listeria_phage	6.9e-110	63.3
WP_052042129.1\|3438333_3438540_-	hypothetical protein	A0A290GDU5	Caldibacillus_phage	5.0e-05	42.0
WP_035182881.1\|3438536_3438773_-	hypothetical protein	NA	NA	NA	NA
WP_155375947.1\|3439447_3439588_-	hypothetical protein	NA	NA	NA	NA
WP_035182885.1\|3439657_3439942_-	hypothetical protein	NA	NA	NA	NA
WP_035182887.1\|3439941_3440460_-	hypothetical protein	A0A290FZK9	Caldibacillus_phage	1.5e-21	36.7
WP_035182888.1\|3440523_3440709_-	helix-turn-helix domain-containing protein	U5P0W4	Brevibacillus_phage	6.0e-10	61.8
WP_035182890.1\|3440709_3441495_-	phage antirepressor KilAC domain-containing protein	R9VWW9	Paenibacillus_phage	9.3e-52	45.8
WP_035182893.1\|3441495_3441723_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_035182898.1\|3441884_3442313_+	helix-turn-helix transcriptional regulator	A0A2P1JU09	Anoxybacillus_phage	1.8e-41	66.0
WP_052042130.1\|3442325_3442739_+	ImmA/IrrE family metallo-endopeptidase	A0A2P1JU12	Anoxybacillus_phage	3.2e-59	78.1
WP_035182902.1\|3442841_3443189_+	PH domain-containing protein	NA	NA	NA	NA
WP_035182903.1\|3443253_3443586_+	membrane protein	S5MNN8	Brevibacillus_phage	4.2e-14	66.0
WP_080738156.1\|3443603_3444845_+	thermonuclease family protein	A0A1P8CWK6	Bacillus_phage	5.6e-67	73.5
WP_029142701.1\|3444949_3446176_+\|integrase	site-specific integrase	S5MNZ2	Brevibacillus_phage	1.0e-92	47.6
3446262:3446310	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP010525

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection