CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022777	Clostridium tetani 12124569, complete genome	8 crisprs	csa3,WYL,cas3,DEDDh,cas2,cas1,cas4,cas5,cas7,cas8b2,cas6,cas7b,cas8b1,RT	0	33	3	0
NC_022778	Clostridium tetani 12124569 plasmid p12124569, complete sequence	0 crisprs	NA	0	0	0	0

1. NC_022777

CRISPR-Cas detection and classification

Crispr_ID: NC_022777_1

• CRISPR_ID: NC_022777_1
• CRISPR_location: 1469658-1471149
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 22 spacers
• Cas_protein_info: cas2,cas1,cas4,cas3,cas5,cas7,cas8b2,cas6

Consensus repeat of NC_022777_1

Consensus_repeat	Method
AATTTACATTCCAATATGGTGCTACTAATAC	CRISPRCasFinder
ATTTACATTCCAATATGGTGCTACTAATAC	PILER-CR
ATTTACATTCCAATATGGTGCTACTAATAC	CRT

spacers of NC_022777_1

>1.1|1469689|36|NC_022777|CRISPRCasFinder
TGACTTTTAACTTCTCCTTATCACTCAGCCTCACAG
>1.2|1469756|34|NC_022777|CRISPRCasFinder
TTTGCTTTATCCTCTACTAATTTACGGCGTGCTT
>1.3|1469821|36|NC_022777|CRISPRCasFinder
ATATAACTTGTAAAAAATGTGAAAATTCTCTTACAT
>1.4|1469888|36|NC_022777|CRISPRCasFinder
TTAATTGTAACTCTTCTAATAGTTTCTCCTTCTCTT
>1.5|1469955|36|NC_022777|CRISPRCasFinder
TAGAAACACATACTAAATTAATGATAAATAGATTAA
>1.6|1470022|36|NC_022777|CRISPRCasFinder
TAAGCTTGATTTTCTGAAACTTTTTCTTCTACAAAT
>1.7|1470089|36|NC_022777|CRISPRCasFinder
GGATACGAACAACAAGTATTAAATATATCTAAATCA
>1.8|1470156|35|NC_022777|CRISPRCasFinder
CCCCATATACCCTACATATATCATCTACTGTTCTT
>1.9|1470222|35|NC_022777|CRISPRCasFinder
TTTTTCTGGATTTAAAAGAAGTACTCCAGCACTTT
>1.10|1470288|35|NC_022777|CRISPRCasFinder
TACTTATTGTAGGTGCTTTTTCTTATTATCTAAGA
>1.11|1470354|36|NC_022777|CRISPRCasFinder
CATTCCCATGCTCCCCCTTTTTTTTATTTGATCAAA
>1.12|1470421|35|NC_022777|CRISPRCasFinder
TTTATTAGTACTTAGTAGTGTCTGATTATCCGTTT
>1.13|1470487|36|NC_022777|CRISPRCasFinder
TGCATTACAAGTTCTTTTATGTTATTATAAATTTAA
>1.14|1470554|36|NC_022777|CRISPRCasFinder
GTCCATTTTCTAATATTTTATATTCCTTTGTAAAAC
>1.15|1470621|36|NC_022777|CRISPRCasFinder
TCATCAAACAGTTTATAAATTGCATCATAAACTTTA
>1.16|1470688|36|NC_022777|CRISPRCasFinder
TAAAGGCAGGTGAAAAAAATGATACCACTAGATGAA
>1.17|1470755|35|NC_022777|CRISPRCasFinder
AGTTGCAAAGATAGCTTCAAAAGAAGATATAAAGA
>1.18|1470821|35|NC_022777|CRISPRCasFinder
GATTCAAAAGACTATGGCTGAATCATTTAAAGCTG
>1.19|1470887|35|NC_022777|CRISPRCasFinder
GTTATAGGAAGAATTCTTTCTTCCAATAAAGTACC
>1.20|1470953|34|NC_022777|CRISPRCasFinder
GTTGAGAAACGATATAAAAAATCAATAGTAGCCA
>1.21|1471018|35|NC_022777|CRISPRCasFinder
TGAAATATTCCTGTATCGGGTTCATATGGTGCATC
>1.22|1471084|35|NC_022777|CRISPRCasFinder
CATCTATAAGAGTAGAAAGTTCCCTAACTGGGATA
>1.23|1469689|37|NC_022777|PILER-CR,CRT
TGACTTTTAACTTCTCCTTATCACTCAGCCTCACAGG
>1.24|1469756|35|NC_022777|PILER-CR,CRT
TTTGCTTTATCCTCTACTAATTTACGGCGTGCTTC
>1.25|1469821|37|NC_022777|PILER-CR,CRT
ATATAACTTGTAAAAAATGTGAAAATTCTCTTACATA
>1.26|1469888|37|NC_022777|PILER-CR,CRT
TTAATTGTAACTCTTCTAATAGTTTCTCCTTCTCTTG
>1.27|1469955|37|NC_022777|PILER-CR,CRT
TAGAAACACATACTAAATTAATGATAAATAGATTAAA
>1.28|1470022|37|NC_022777|PILER-CR,CRT
TAAGCTTGATTTTCTGAAACTTTTTCTTCTACAAATA
>1.29|1470089|37|NC_022777|PILER-CR,CRT
GGATACGAACAACAAGTATTAAATATATCTAAATCAA
>1.30|1470156|36|NC_022777|PILER-CR,CRT
CCCCATATACCCTACATATATCATCTACTGTTCTTA
>1.31|1470222|36|NC_022777|PILER-CR,CRT
TTTTTCTGGATTTAAAAGAAGTACTCCAGCACTTTG
>1.32|1470288|36|NC_022777|PILER-CR,CRT
TACTTATTGTAGGTGCTTTTTCTTATTATCTAAGAA
>1.33|1470354|37|NC_022777|PILER-CR,CRT
CATTCCCATGCTCCCCCTTTTTTTTATTTGATCAAAA
>1.34|1470421|36|NC_022777|PILER-CR,CRT
TTTATTAGTACTTAGTAGTGTCTGATTATCCGTTTT
>1.35|1470487|37|NC_022777|PILER-CR,CRT
TGCATTACAAGTTCTTTTATGTTATTATAAATTTAAC
>1.36|1470554|37|NC_022777|PILER-CR,CRT
GTCCATTTTCTAATATTTTATATTCCTTTGTAAAACG
>1.37|1470621|37|NC_022777|PILER-CR,CRT
TCATCAAACAGTTTATAAATTGCATCATAAACTTTAA
>1.38|1470688|37|NC_022777|PILER-CR,CRT
TAAAGGCAGGTGAAAAAAATGATACCACTAGATGAAA
>1.39|1470755|36|NC_022777|PILER-CR,CRT
AGTTGCAAAGATAGCTTCAAAAGAAGATATAAAGAT
>1.40|1470821|36|NC_022777|PILER-CR,CRT
GATTCAAAAGACTATGGCTGAATCATTTAAAGCTGA
>1.41|1470887|36|NC_022777|PILER-CR,CRT
GTTATAGGAAGAATTCTTTCTTCCAATAAAGTACCA
>1.42|1470953|35|NC_022777|PILER-CR,CRT
GTTGAGAAACGATATAAAAAATCAATAGTAGCCAA
>1.43|1471018|36|NC_022777|PILER-CR,CRT
TGAAATATTCCTGTATCGGGTTCATATGGTGCATCA
>1.44|1471084|36|NC_022777|PILER-CR,CRT
CATCTATAAGAGTAGAAAGTTCCCTAACTGGGATAA

CRISPR arrays and Neighbor proteins around NC_022777_1

CRISPR arrays

The CRISPR arrays of NC_022777_1

>merge|NC_022777|1|1469658-1471149|CRISPRCasFinder,PILER-CR,CRT
TATTTACATTCCAATATGGTGCTACTAATACTGACTTTTAACTTCTCCTTATCACTCAGCCTCACAGGATTTACATTCCAATATGGTGCTACTAATACTTTGCTTTATCCTCTACTAATTTACGGCGTGCTTCATTTACATTCCAATATGGTGCTACTAATACATATAACTTGTAAAAAATGTGAAAATTCTCTTACATAATTTACATTCCAATATGGTGCTACTAATACTTAATTGTAACTCTTCTAATAGTTTCTCCTTCTCTTGATTTACATTCCAATATGGTGCTACTAATACTAGAAACACATACTAAATTAATGATAAATAGATTAAAATTTACATTCCAATATGGTGCTACTAATACTAAGCTTGATTTTCTGAAACTTTTTCTTCTACAAATAATTTACATTCCAATATGGTGCTACTAATACGGATACGAACAACAAGTATTAAATATATCTAAATCAAATTTACATTCCAATATGGTGCTACTAATACCCCCATATACCCTACATATATCATCTACTGTTCTTAATTTACATTCCAATATGGTGCTACTAATACTTTTTCTGGATTTAAAAGAAGTACTCCAGCACTTTGATTTACATTCCAATATGGTGCTACTAATACTACTTATTGTAGGTGCTTTTTCTTATTATCTAAGAAATTTACATTCCAATATGGTGCTACTAATACCATTCCCATGCTCCCCCTTTTTTTTATTTGATCAAAAATTTACATTCCAATATGGTGCTACTAATACTTTATTAGTACTTAGTAGTGTCTGATTATCCGTTTTATTTACATTCCAATATGGTGCTACTAATACTGCATTACAAGTTCTTTTATGTTATTATAAATTTAACATTTACATTCCAATATGGTGCTACTAATACGTCCATTTTCTAATATTTTATATTCCTTTGTAAAACGATTTACATTCCAATATGGTGCTACTAATACTCATCAAACAGTTTATAAATTGCATCATAAACTTTAAATTTACATTCCAATATGGTGCTACTAATACTAAAGGCAGGTGAAAAAAATGATACCACTAGATGAAAATTTACATTCCAATATGGTGCTACTAATGCAGTTGCAAAGATAGCTTCAAAAGAAGATATAAAGATATTTACATTCCAATATGGTGCTACTAATACGATTCAAAAGACTATGGCTGAATCATTTAAAGCTGAATTTACATTCCAATATGGTGCTACTAATACGTTATAGGAAGAATTCTTTCTTCCAATAAAGTACCAATTTACATTCCAATATGGTGCTACTAATACGTTGAGAAACGATATAAAAAATCAATAGTAGCCAAATTTACATTCCAATATGGTGCTACTAATACTGAAATATTCCTGTATCGGGTTCATATGGTGCATCAATTTACATTCCAATATGGTGCTACTAATACCATCTATAAGAGTAGAAAGTTCCCTAACTGGGATAAATTTACATTCCAATATGGTGCTACTAATAC

>NC_022777|1|1|1469658-1471149|CRISPRCasFinder
TATTTACATTCCAATATGGTGCTACTAATAC	TGACTTTTAACTTCTCCTTATCACTCAGCCTCACAG
GATTTACATTCCAATATGGTGCTACTAATAC	TTTGCTTTATCCTCTACTAATTTACGGCGTGCTT
CATTTACATTCCAATATGGTGCTACTAATAC	ATATAACTTGTAAAAAATGTGAAAATTCTCTTACAT
AATTTACATTCCAATATGGTGCTACTAATAC	TTAATTGTAACTCTTCTAATAGTTTCTCCTTCTCTT
GATTTACATTCCAATATGGTGCTACTAATAC	TAGAAACACATACTAAATTAATGATAAATAGATTAA
AATTTACATTCCAATATGGTGCTACTAATAC	TAAGCTTGATTTTCTGAAACTTTTTCTTCTACAAAT
AATTTACATTCCAATATGGTGCTACTAATAC	GGATACGAACAACAAGTATTAAATATATCTAAATCA
AATTTACATTCCAATATGGTGCTACTAATAC	CCCCATATACCCTACATATATCATCTACTGTTCTT
AATTTACATTCCAATATGGTGCTACTAATAC	TTTTTCTGGATTTAAAAGAAGTACTCCAGCACTTT
GATTTACATTCCAATATGGTGCTACTAATAC	TACTTATTGTAGGTGCTTTTTCTTATTATCTAAGA
AATTTACATTCCAATATGGTGCTACTAATAC	CATTCCCATGCTCCCCCTTTTTTTTATTTGATCAAA
AATTTACATTCCAATATGGTGCTACTAATAC	TTTATTAGTACTTAGTAGTGTCTGATTATCCGTTT
TATTTACATTCCAATATGGTGCTACTAATAC	TGCATTACAAGTTCTTTTATGTTATTATAAATTTAA
CATTTACATTCCAATATGGTGCTACTAATAC	GTCCATTTTCTAATATTTTATATTCCTTTGTAAAAC
GATTTACATTCCAATATGGTGCTACTAATAC	TCATCAAACAGTTTATAAATTGCATCATAAACTTTA
AATTTACATTCCAATATGGTGCTACTAATAC	TAAAGGCAGGTGAAAAAAATGATACCACTAGATGAA
AATTTACATTCCAATATGGTGCTACTAATGC	AGTTGCAAAGATAGCTTCAAAAGAAGATATAAAGA
TATTTACATTCCAATATGGTGCTACTAATAC	GATTCAAAAGACTATGGCTGAATCATTTAAAGCTG
AATTTACATTCCAATATGGTGCTACTAATAC	GTTATAGGAAGAATTCTTTCTTCCAATAAAGTACC
AATTTACATTCCAATATGGTGCTACTAATAC	GTTGAGAAACGATATAAAAAATCAATAGTAGCCA
AATTTACATTCCAATATGGTGCTACTAATAC	TGAAATATTCCTGTATCGGGTTCATATGGTGCATC
AATTTACATTCCAATATGGTGCTACTAATAC	CATCTATAAGAGTAGAAAGTTCCCTAACTGGGATA
AATTTACATTCCAATATGGTGCTACTAATAC

>NC_022777|1|1|1469659-1471149|PILER-CR
ATTTACATTCCAATATGGTGCTACTAATAC	TGACTTTTAACTTCTCCTTATCACTCAGCCTCACAGG
ATTTACATTCCAATATGGTGCTACTAATAC	TTTGCTTTATCCTCTACTAATTTACGGCGTGCTTC
ATTTACATTCCAATATGGTGCTACTAATAC	ATATAACTTGTAAAAAATGTGAAAATTCTCTTACATA
ATTTACATTCCAATATGGTGCTACTAATAC	TTAATTGTAACTCTTCTAATAGTTTCTCCTTCTCTTG
ATTTACATTCCAATATGGTGCTACTAATAC	TAGAAACACATACTAAATTAATGATAAATAGATTAAA
ATTTACATTCCAATATGGTGCTACTAATAC	TAAGCTTGATTTTCTGAAACTTTTTCTTCTACAAATA
ATTTACATTCCAATATGGTGCTACTAATAC	GGATACGAACAACAAGTATTAAATATATCTAAATCAA
ATTTACATTCCAATATGGTGCTACTAATAC	CCCCATATACCCTACATATATCATCTACTGTTCTTA
ATTTACATTCCAATATGGTGCTACTAATAC	TTTTTCTGGATTTAAAAGAAGTACTCCAGCACTTTG
ATTTACATTCCAATATGGTGCTACTAATAC	TACTTATTGTAGGTGCTTTTTCTTATTATCTAAGAA
ATTTACATTCCAATATGGTGCTACTAATAC	CATTCCCATGCTCCCCCTTTTTTTTATTTGATCAAAA
ATTTACATTCCAATATGGTGCTACTAATAC	TTTATTAGTACTTAGTAGTGTCTGATTATCCGTTTT
ATTTACATTCCAATATGGTGCTACTAATAC	TGCATTACAAGTTCTTTTATGTTATTATAAATTTAAC
ATTTACATTCCAATATGGTGCTACTAATAC	GTCCATTTTCTAATATTTTATATTCCTTTGTAAAACG
ATTTACATTCCAATATGGTGCTACTAATAC	TCATCAAACAGTTTATAAATTGCATCATAAACTTTAA
ATTTACATTCCAATATGGTGCTACTAATAC	TAAAGGCAGGTGAAAAAAATGATACCACTAGATGAAA
ATTTACATTCCAATATGGTGCTACTAATGC	AGTTGCAAAGATAGCTTCAAAAGAAGATATAAAGAT
ATTTACATTCCAATATGGTGCTACTAATAC	GATTCAAAAGACTATGGCTGAATCATTTAAAGCTGA
ATTTACATTCCAATATGGTGCTACTAATAC	GTTATAGGAAGAATTCTTTCTTCCAATAAAGTACCA
ATTTACATTCCAATATGGTGCTACTAATAC	GTTGAGAAACGATATAAAAAATCAATAGTAGCCAA
ATTTACATTCCAATATGGTGCTACTAATAC	TGAAATATTCCTGTATCGGGTTCATATGGTGCATCA
ATTTACATTCCAATATGGTGCTACTAATAC	CATCTATAAGAGTAGAAAGTTCCCTAACTGGGATAA
ATTTACATTCCAATATGGTGCTACTAATAC

>NC_022777|1|1|1469659-1471149|CRT
ATTTACATTCCAATATGGTGCTACTAATAC	TGACTTTTAACTTCTCCTTATCACTCAGCCTCACAGG
ATTTACATTCCAATATGGTGCTACTAATAC	TTTGCTTTATCCTCTACTAATTTACGGCGTGCTTC
ATTTACATTCCAATATGGTGCTACTAATAC	ATATAACTTGTAAAAAATGTGAAAATTCTCTTACATA
ATTTACATTCCAATATGGTGCTACTAATAC	TTAATTGTAACTCTTCTAATAGTTTCTCCTTCTCTTG
ATTTACATTCCAATATGGTGCTACTAATAC	TAGAAACACATACTAAATTAATGATAAATAGATTAAA
ATTTACATTCCAATATGGTGCTACTAATAC	TAAGCTTGATTTTCTGAAACTTTTTCTTCTACAAATA
ATTTACATTCCAATATGGTGCTACTAATAC	GGATACGAACAACAAGTATTAAATATATCTAAATCAA
ATTTACATTCCAATATGGTGCTACTAATAC	CCCCATATACCCTACATATATCATCTACTGTTCTTA
ATTTACATTCCAATATGGTGCTACTAATAC	TTTTTCTGGATTTAAAAGAAGTACTCCAGCACTTTG
ATTTACATTCCAATATGGTGCTACTAATAC	TACTTATTGTAGGTGCTTTTTCTTATTATCTAAGAA
ATTTACATTCCAATATGGTGCTACTAATAC	CATTCCCATGCTCCCCCTTTTTTTTATTTGATCAAAA
ATTTACATTCCAATATGGTGCTACTAATAC	TTTATTAGTACTTAGTAGTGTCTGATTATCCGTTTT
ATTTACATTCCAATATGGTGCTACTAATAC	TGCATTACAAGTTCTTTTATGTTATTATAAATTTAAC
ATTTACATTCCAATATGGTGCTACTAATAC	GTCCATTTTCTAATATTTTATATTCCTTTGTAAAACG
ATTTACATTCCAATATGGTGCTACTAATAC	TCATCAAACAGTTTATAAATTGCATCATAAACTTTAA
ATTTACATTCCAATATGGTGCTACTAATAC	TAAAGGCAGGTGAAAAAAATGATACCACTAGATGAAA
ATTTACATTCCAATATGGTGCTACTAATGC	AGTTGCAAAGATAGCTTCAAAAGAAGATATAAAGAT
ATTTACATTCCAATATGGTGCTACTAATAC	GATTCAAAAGACTATGGCTGAATCATTTAAAGCTGA
ATTTACATTCCAATATGGTGCTACTAATAC	GTTATAGGAAGAATTCTTTCTTCCAATAAAGTACCA
ATTTACATTCCAATATGGTGCTACTAATAC	GTTGAGAAACGATATAAAAAATCAATAGTAGCCAA
ATTTACATTCCAATATGGTGCTACTAATAC	TGAAATATTCCTGTATCGGGTTCATATGGTGCATCA
ATTTACATTCCAATATGGTGCTACTAATAC	CATCTATAAGAGTAGAAAGTTCCCTAACTGGGATAA
ATTTACATTCCAATATGGTGCTACTAATAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022777.1|WP_023438278.1|1459181_1459988_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213224
NC_022777.1|WP_023438280.1|1460842_1461640_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|131837
NC_022777.1|WP_023438287.1|1466886_1467873_+|sulfide/dihydroorotate-dehydrogenase-like-FAD/NAD-binding-protein	unknown	unknown	gnl|CDD|235613
NC_022777.1|WP_023438282.1|1462580_1464140_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|173855
NC_022777.1|WP_023438290.1|1471619_1472612_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_022777.1|WP_023438295.1|1477507_1478851_-|type-I-CRISPR-associated-protein-Cas8a1/Csx8	cas8b2	cd09744_cas8b2_CAS-I-B	gnl|CDD|187875
NC_022777.1|WP_023438293.1|1475482_1476565_-|CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl|CDD|274218
NC_022777.1|WP_023438299.1|1481063_1481918_-|CPBP-family-intramembrane-metalloprotease	unknown	unknown	unknown
NC_022777.1|WP_045923686.1|1472629_1473124_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NC_022777.1|WP_023438289.1|1471327_1471606_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_022777.1|WP_023438284.1|1465290_1465485_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224393
NC_022777.1|WP_023438294.1|1476592_1477492_-|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl|CDD|274215
NC_022777.1|WP_082208650.1|1473152_1475483_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl|CDD|273707
NC_022777.1|WP_023438285.1|1465541_1466678_-|VanZ-family-protein	unknown	unknown	gnl|CDD|377417
NC_022777.1|WP_023438296.1|1478865_1479609_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_022777.1|WP_023438279.1|1460013_1460829_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|223521
NC_022777.1|WP_023438283.1|1464760_1465267_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438288.1|1467869_1469147_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|250388
NC_022777.1|WP_045923593.1|1479938_1480319_-|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl|CDD|368098
NC_022777.1|WP_023438281.1|1461629_1462577_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|223674

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_022777.1|WP_023438296.1|1478865_1479609_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	2.3e-30	101.2	7.0
NC_022777.1|WP_023438295.1|1477507_1478851_-|type-I-CRISPR-associated-protein-Cas8a1/Csx8	cas8b2	cd09744_cas8b2_CAS-I-B	9e-216	711.6	44.8
NC_022777.1|WP_023438290.1|1471619_1472612_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	1.8e-135	445.9	17.9
NC_022777.1|WP_082208650.1|1473152_1475483_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	1.7e-74	246.1	30.2
NC_022777.1|WP_045923686.1|1472629_1473124_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	2.7e-52	171.9	5.8
NC_022777.1|WP_023438293.1|1475482_1476565_-|CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	2e-20	68.3	24.2
NC_022777.1|WP_023438289.1|1471327_1471606_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	4.2e-26	85.7	1.3
NC_022777.1|WP_023438294.1|1476592_1477492_-|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	3e-76	251.2	8.4

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022777.1|WP_023438278.1|1459181_1459988_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213224	cd03257, ABC_NikE_OppD_transporters, ATP-binding cassette domain of nickel/oligopeptides specific transporters. The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.	9.44796e-93
NC_022777.1|WP_023438280.1|1460842_1461640_-|ABC-transporter-permease	gnl|CDD|131837	TIGR02790, Nickel_transport_system_permease_protein_nikC., nickel ABC transporter, permease subunit NikC. This family consists of the NikC family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikB. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds].	3.21397e-84
NC_022777.1|WP_023438287.1|1466886_1467873_+|sulfide/dihydroorotate-dehydrogenase-like-FAD/NAD-binding-protein	gnl|CDD|235613	PRK05802, PRK05802, sulfide/dihydroorotate dehydrogenase-like FAD/NAD-binding protein.	4.41376e-174
NC_022777.1|WP_023438282.1|1462580_1464140_-|ABC-transporter-substrate-binding-protein	gnl|CDD|173855	cd08490, PBP2_NikA_DppA_OppA_like_3, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NC_022777.1|WP_023438290.1|1471619_1472612_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	2.50191e-163
NC_022777.1|WP_023438295.1|1477507_1478851_-|type-I-CRISPR-associated-protein-Cas8a1/Csx8	gnl|CDD|187875	cd09744, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as Csx8 family.	0
NC_022777.1|WP_023438293.1|1475482_1476565_-|CRISPR-associated-protein-Cas5	gnl|CDD|274218	TIGR02593, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5, N-terminal domain. This model represents a shared N-terminal domain, about 43 amino acids in length, common to a number of related protein families each of which is associated with a distinct subtype of CRISPR/cas system, where CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeat and Cas is an abbreviation for CRISPR-associated. Members of this family are widely distributed enough that we designated the family Cas5. Homology appears remote, or absent, between the more C-terminal regions different subfamilies of these proteins, which typically are 210 to 265 amino acids in total length. Cas5 proteins of six different CRISPR/cas subtypes so far defined are described by respective full-length models TIGR01868, TIGR01876, TIGR01895, TIGR01874, TIGR02586, and TIGR02592. The best characterized protein in this family is DevS or Myxococcus xanthus, a Cas protein that appears to participate in a species-specific developmental pathway.	2.47199e-12
NC_022777.1|WP_045923686.1|1472629_1473124_-|CRISPR-associated-protein-Cas4	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.82354e-62
NC_022777.1|WP_023438289.1|1471327_1471606_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.59005e-25
NC_022777.1|WP_023438284.1|1465290_1465485_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	2.38783e-24
NC_022777.1|WP_023438294.1|1476592_1477492_-|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl|CDD|274215	TIGR02585, conserved_protein, CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This clade is a member of the DevR family (TIGR01875) and includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to be regulated through a number of means, including both location and autorepression; DevR mutants are incapable of fruiting body development.	9.8264e-74
NC_022777.1|WP_023438285.1|1465541_1466678_-|VanZ-family-protein	gnl|CDD|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	1.34172e-17
NC_022777.1|WP_023438296.1|1478865_1479609_-|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	5.29268e-28
NC_022777.1|WP_023438279.1|1460013_1460829_-|ABC-transporter-ATP-binding-protein	gnl|CDD|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	9.92331e-110
NC_022777.1|WP_082208650.1|1473152_1475483_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	3.33735e-59
NC_022777.1|WP_023438288.1|1467869_1469147_+|FAD-dependent-oxidoreductase	gnl|CDD|250388	pfam01134, GIDA, Glucose inhibited division protein A.	1.8236e-71
NC_022777.1|WP_045923593.1|1479938_1480319_-|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl|CDD|368098	pfam04754, Transposase_31, Putative transposase, YhgA-like. This family of putative transposases includes the YhgA sequence from Escherichia coli and several prokaryotic homologs.	3.20494e-54
NC_022777.1|WP_023438281.1|1461629_1462577_-|ABC-transporter-permease	gnl|CDD|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.38151e-101

Protein sequences

>NC_022777.1|WP_023438288.1|1467869_1469147_+|FAD-dependent-oxidoreductase
MKVIVIGGGWAGASAAITAKKAGAQVILYEKTDMLIGLGNVGGIMRNNGRYTAAEELINLGAGDLIKITDKNTRHKNIDFPGHNHAWLYDVNKIEPDVRDYLTSLGIEINFMNRVVDIEKEDKTIRGIYLSDGTYVKGDVFIEATGSTGPMGNCLRYGNGCSMCILRCPSFGPRVSISARAGVEDLQGEREDDVYGAFSGSCKLCKESLSEDLLKEIEEKGSVVLKVPPEDVNLDKLKLKVCQQYALKEFAENIVLLDTGHIKLMSSYYPLDKLRKIKGLEKAKYIDPYAGGKANSIRYLSVAPRRDSMKVKGIDNLFCAGEKSGLFVGHTEAMCTGALAGHNAVRHLLGMPLLILPKTLAIGDLISYANFKMATKEGRRKRYTFAGAEYFERMKNTGLYSTDNQEIVKRVEKLNLLGIMEGKMV
>NC_022777.1|WP_023438287.1|1466886_1467873_+|sulfide/dihydroorotate-dehydrogenase-like-FAD/NAD-binding-protein
MNYEIKDCIDAGTEYCPCHLAEANECILCSQLRDKDFCDCINWKGVCIYQEFVWNGKKPKEGRKEIECTLLEKEYLYEDLAILKIDVPHKLAKELTSPGSFVFLRNFCEGQFFSAPISVMESNVEENIITLALEIKGIKTKKINKVNAGEKILVKGPFWNGIFGLKNINKSKDKTSIVIARGIGQAPIVPLIKKLYSNGNKIYTLLDEKPFNKSFIDKYLEQYNCHVINTTLIGDKGELTSEFKNILLSIIREDDVNLVHSSAADIINYNVLNLIGETIDFSCCNNAKMCCGEGICGSCSVKNKYFDIERSCKLQIDPRNILEGRKLL
>NC_022777.1|WP_023438285.1|1465541_1466678_-|VanZ-family-protein
MYAYVFPIKIALLTVIFLIYLAFIPYCIIQYRKHGFLSKYRSFMHIAFVFYIISAFYLVILPLPDRNFVPKHIIHPQLIPFNFIGDFFKEYSNLVARGFSTPSSILKNRGLWQVFFNVLLLTPLGFFLRYFYNINFKKALAISFLTSLFFEVTQLTGIFGIYKYAYRLFDVDDLMLNTIGGVIGYYLVPISKKILPNIDEIDLRYNYDESKVGYIRRGIAFAADLLIVSFIPLINRKNDITSIWFILYIILLPYITNGYTLGKKLVKIRIVNESNTKLKLIELIKRYFWLIVISVLRIIFGLNLLSNFHTTVISIINIIYLIIILIIGFKLFIGLFNKNKTMFYEEFSRTHIANSFKLKSNKNDINRDDGNKEHINKH
>NC_022777.1|WP_023438284.1|1465290_1465485_+|helix-turn-helix-transcriptional-regulator
MKNMKLKLARVEKELSQEDLAKIVGVTRQTIGLIESGKYNPTLSLCIAICKVLSRTLDDLFWEE
>NC_022777.1|WP_023438283.1|1464760_1465267_+|hypothetical-protein
MKLFKKNNHIVDERIENIKNKIYKEISILVMLVCTISIIVKYSMYGQNIKLVATELLIMFSTSVYYVVRIVYLGIYSDEVEMHDRTSKISMNTKNIIIGLVIGISIAIFFGFRSALLYGTTPSIRVQYFSIVFIVSILIYLPFFIIFLTFQHSIANKISKKQSLKRIN
>NC_022777.1|WP_023438282.1|1462580_1464140_-|ABC-transporter-substrate-binding-protein
MKNKISKSINILLVLFLMIISFAGCNGSKDTGAIGDDKKQGEKKVTYLYVHATNTLNPHLKASGNIPIRTGAVETLVRIDEDLKLKPWLLEKWNSKDAKHWEFKVRKGIKFHNGTSLDANIVKANIEACIKNNPGIKNALNIESMEAKEDILKIVTKKPNASLPSEFVHPNTAIIDVNASDIDTKPCGTGAFKVENFKPNSSIQLVKNDKYWDGEVKVDKVNFEFNQDANARLQALQSGYADIIFKPAAESIETLKKDSKVTIDTMPGLRTNELLYNIKKPLTGNEYFRKGLDSLINRKEIVENIMSAQATIAYGPFMEGLPFAIDYEKNQFGLDKALENFKKAGLTVTDGKVLDNGKPIKLKVVTYASRAELPPIAQLVQSNAKKIGIEMDISIVEGENVDNHLKRDDWDFCVYSLLTAPRGDAGYYLNSSIKPEGSLNHGYINDDKLTTIINEFNSCIDETKRNELAKQATTIINKKNYNSYVAYPNVIVAYNNQRISNWKTSPSEFYMITKDLDVK
>NC_022777.1|WP_023438281.1|1461629_1462577_-|ABC-transporter-permease
MYGISKRLAKVLVFFFLLSFFSFMILKLAPGDPVMNILGTQEVAVSNQDVEQLREQLGLNKPMVIQYCDWLKKVIHLDFGNSLITGKSVASGIGKAFPRTLLLALSSITVMFLIAVPLGVGSALYRDGVINKISEIFNLIGSSIPGFWLGFILVDIFAIKLNLLPSMGVGGLKHLILPSLTLGISMAPPYVRLLKTSIIESMEQDFIQSAKARGVLEVRIFFFHVLRKSLIPVLTLFGMSMGSLMGGTVVIEVLFSYPGLGKLAIEAITNRDYSMIQGFILFTGMLVFVINLIVDVLHRFIDPSIAIKEAEQIEI
>NC_022777.1|WP_023438280.1|1460842_1461640_-|ABC-transporter-permease
MKSKINFKMVFFIFIILVMVIGKICTPYDPNLVDMSISLQPPSSQHLFGTDNLGRDVFSRVLSGAWTTVGTGIIILILSLLIGVPIGLFSGYVGGKVDWVIMRFIDSFIAFPDYIVAIVLSGILGSGTFNLILAIVAVKWVRYARLVRSTVQSEKTKDYILIAKLNGLNTISILNKHLIPHIVGNITAVATMDMGKIILMIASLSYIGLGVQPPNPEWGSMLNEGRTFFQSAPHLMIAPGLAIMIVVLAVNLFGDSISKQYSTRK
>NC_022777.1|WP_023438279.1|1460013_1460829_-|ABC-transporter-ATP-binding-protein
MSVVNINNLIIHANKRPVVDNVSFSINEGEWLALIGESGSGKSVTASSIGLLIHKNLNLVSGDINLNGIDIRSLNEEELRKIRGKEVAYIFQDYQNAFTPFIKIGKQIEEMIKCHIDISDKERKKRILKSLNEVGLDEKRVFNSYPFQLSGGQLQRAAIAQAVILKPKLLIADEPTTALDALTNSKVLELLLDIKEKTKCALLFITHDLRCAKNYANKIAIMHNGKIVEMGSRDKIVNNPEHIYTKNLFASIPPMRHVPKRLYITGEYKII
>NC_022777.1|WP_023438278.1|1459181_1459988_-|ABC-transporter-ATP-binding-protein
MDSISIPEEDIKDNLLVVDKVVKKYSNGHLALKDASFSMKKGECLGLVGESGSGKSTLARCILMFERIDKGEIWLNGEAIHNMKKTEFRKKQRNMQAVFQNPTASLNSKLKIIDSLMEPLDYQPDVIPSFLKDIRSNRRKSAKALLNMVELPSRYLDSYPCELSGGQKQRVIIARAISVEPSLIILDEPTASLDVSIQARVLNLLKDLQENLGLSYFFISHDLSAVNFMCQRMMVMKEGVIVDRCNRKGLFDKERHSYTKDLLKVFEA
>NC_022777.1|WP_023438289.1|1471327_1471606_-|CRISPR-associated-endonuclease-Cas2
MYVILVYDIKSDEDGQRVLNRTFKTCKKYLSHIQNSVFEGELAESQIIKLKYELDSIIRKDKDSVILFKSRSKKWLNKDMWGKKEDRTSNFI
>NC_022777.1|WP_023438290.1|1471619_1472612_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MKRSYYIYNNGALKRKDNSIAFIDELGERRYIPIETVNEIYVMSEMDFNTSLINYLSQYDVIIHFFNYYSFYTGSFQPRKKLVSGNLLVNQVNHYSDNNKRLEIAKKFVDGASYNIYRNLRYYNGRGKDVQTYMDKIEALRKQIYVSANINELMGYEGNIRKIYYEAWNIIIDQKIDFTKRVKNPPDNMINTLISFINTLVYTKILGAIYHTQLNPTVSYLHEPGIRRFSLSLDIAEIFKPILADRLIFSLLNKKQITKKSFTKELNYLHLTKDASKIIVGELDQKLQTTIKHKDLNKNVSYEYLMRLECYKLIKHLLGEKEYEPFKIWW
>NC_022777.1|WP_045923686.1|1472629_1473124_-|CRISPR-associated-protein-Cas4
MKKEITGVMIYYYKVCKRKLWYFYNEIQMEQGNQSVEIGKAIDEETYRRDKKHINIDNIINIDFIRSKGILHEVKKSNKIEEASILQVKYYLYFLNKRGIENIKGKIDYPLLKQNIDVELTREDVTMIEEILDDIQNIVKASNPPNLEKKRICKSCAYYDLCFI
>NC_022777.1|WP_082208650.1|1473152_1475483_-|CRISPR-associated-helicase/endonuclease-Cas3
MKGSRKPSCCFIIRRRIMEGKLKILDNDTLKLIEEKKAKPDKTIKEHTLELIEVLNLLRDLGYIKNDKIYELVEKACIYHDLGKLNKEFQKRVNGKNIKFNETKEVVHNILSLYFINSKNFENQEDYLKVAHSVLNHHNYCNNFDEMSEKEDLIQNLIDGFKTYKVKRSVKSKLASIVSDIDSIKIKGYLHKCDYSASSGNVAEYPNKFLENGLKDLLMKWRKGNKEATWNELQNFCIKNKDENIIAVAQTGMGKTEAGLLWIGDTKGFFVLPIRTAINAIYDRVRKDILNNKGIDEKIAILHSSSLEYYIRNITGDTNEKEEIDLMNYHKIGKQLSIPINISTMDQIFDFVYKYPGYELKLTTLSYSKIVIDEIQAYGPDLLAYLICGLEKIAELGGRIAILTATLPPYIKDLLQKNIKFIENSTAFTNDMKRHNLKIIDERINSKDIYNKYVENKELNKNNKILVVCNRIKEAQKLYEELKELINNEELHILHSKFIRKDRLKKESEIIEFGKTYDENKNIDKKNGIWISTSIVEASLDIDFDYLFTELQDLNSLFQRLGRCNRKGKKDSSDYNCYIYAEIDTANLINGDKGFIDKRLFDLSKEAIISYDGQISEKQKVSLIDSYLTTENLKGSDYMRKYKEIYNFIKDIPPYEFDLNQIDLRNILSEEIIPSPVYEEFLEEIKEIECKLANENISYYEKIILKDEIRKYTVSVHPNDIRNYERAKQRGEAINYNRVLLSKHKNDYIKVIECEYDKAGYKRIKYNETTRGSNIW
>NC_022777.1|WP_023438293.1|1475482_1476565_-|CRISPR-associated-protein-Cas5
MKVLRIVLTQSSANYKKEETIDNKMTYPLPPISTIIGAIHNACGYKDYHSMDISVQGKFESMHKEPYTDYCFLNSVMDDRGILLKMRNGSLLSNAFDKVASAKKSQGNSFRKGITIQVYNEELLKEYRDLKDLNDKIAHYKKNEFKEKLDSIKAEKTKLAEDKKKLDKKSKEFEDIVKKEKEVKLKEKEFKEKVKEFELEKYIKPISKFRSLTTSLKYYEILNNVELVIHVRSDEKTLNEIEENIYNLKSIGRSEDFVNIIEAKIVTLKENDDCEIRSNYSAYLNYNDVKNKKVWFENVRADQEVSGTKYYINKNYIIKDGKRFFEKKKVIYASQYSIEETSKNIFIDNEDNKEYIVNFI
>NC_022777.1|WP_023438294.1|1476592_1477492_-|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MKYKKALTLTVVANMTSNYSEGLGNIASVQKVFKNRKVYTIRSRESLKNAIMVQSGMYDDLQTEVDGATQKLVNEELNASNCRALEGGYMSTKGTTNIRKSSFYLTDAISCESFVNETRFHNNLYLANNLAKAKNINVQESPKAAGLMPYQYEYDKSLKIYSITIDLEMIGKDENFEQEENYREADNKEKAGRVNAILNAIENLSLTVKGNLDNAEPVFVVGGLSHRKTHYFENVVKVEEEKLIISGDLKDKIEKGYHVGLLEGKTLQNEREIKEQLNPISITKFFDEVRHEVNTYFGV
>NC_022777.1|WP_023438295.1|1477507_1478851_-|type-I-CRISPR-associated-protein-Cas8a1/Csx8
MKTSIQNEKYDTMLEPSDWRFSAAIVGLLQYLNYHYLDYKMEEDYILYNSSGINEERYLDFVEYKYGDELHHRLVENILSNEEITEEQLKLINEKLVANTIMKKTFGKIKFDNTNKKEILDIINKNRYELIRETFRSKSDMYANYANTNQLFNDSQDYCRLVGYCIDTGKKGKSTGFNFTMNTFVGSDILEFDFIPFAFEGSREAFFINDNYTIQRLKMSNEILSKKIESDLEGESKRKDARQALFKAIMEASDFIKRDVEVILKDISEDYFETLYIRKESIDIFKELINEKIEYKSFCFSHKITDKYYINIQKRVTESILNNVLLDELIEIFLKEKNRSYLVLQLIKINVLIRRDKTMKDRLKGAFACAKQVSKAIESNKLDSYKQKLTSSIIFKDYDRVCQILLQLSNYSGIEFGFVYDLYDDFEENKDLAYTFINALSKKSENN
>NC_022777.1|WP_023438296.1|1478865_1479609_-|CRISPR-associated-endoribonuclease-Cas6
MRFCLTLHLKEKIFPIEYRKVILSYIKNAISKCNNGKYYECFFKDTKQKDYCFSVILPNPAFTKNEIILNGNEIKVLFSTNNNSKIGFILFSAFIAQKNKPYPLPNNNSMILKNINNKKQEEIFNSKAIFKTTLGSGLCVRDHDKEENKDTYYVYTDEKFREKLKVVLVKQILKAGFTEEEAKGIKVNPIQCKKVVVKHYRRYIDTTTGLFEIQANNKILQHFYDAGIGSRKSMGFGMIDLVTQDLL
>NC_022777.1|WP_045923593.1|1479938_1480319_-|Rpn-family-recombination-promoting-nuclease/putative-transposase
MKIQNPHDKFFKETFGNVEVTKDFLNNYLPQNIMNVIDMNTLEPQKDSFINEELQEGFSDMLFKVNINKKEGYIYFVFEHKSYTSIDIAFQLLKYMIEIWESKIKKEKTDKLPMIIPLVIYHGKGS
>NC_022777.1|WP_023438299.1|1481063_1481918_-|CPBP-family-intramembrane-metalloprotease
MQINHNIFSKTESKGKRNVYLFSAVTFMVFIISYILSIKVTQVKDDGMFMYRAWMWTEYLIGIASFIVIVIKFKHIKAEFIFPAIVLTLISSVSLLNRSDIGTTIKEAIILFFSFVAACLLSKGDNNIKSSLVESKFKKAAASFVLGAFISIPLGIVNFLYFKNTMYYLNWQNPITSAFLALQPGIAEEIIFRFFIMNAFITISDKHINKKHMVVISMFLGVVPHSLCHFSELWIISPVNAITMLMLTSLFFGLPMAYLQYKRDLETAISFHWCIDFIRFLGGF

Crispr_ID: NC_022777_2

• CRISPR_ID: NC_022777_2
• CRISPR_location: 1555216-1555440
• CRISPR_type: Orphan
• Repeat_type: III-B
• Spacer_info: 3 spacers

Consensus repeat of NC_022777_2

Consensus_repeat	Method
ATTTAAATACATCCTATGTTAAGGTTCAAC	CRISPRCasFinder
ATTTAAATACATCCTATGTTAAGGTTCAAC	CRT
ATTTAAATACATCCTATGTTAAGGTTCAAC	PILER-CR

spacers of NC_022777_2

>2.1|1555246|35|NC_022777|CRISPRCasFinder,CRT
GTTACTGTGTATATTGGTACAAAAAGAATAAAAAC
>2.2|1555311|35|NC_022777|CRISPRCasFinder,CRT,PILER-CR
GGCTTTATACTTATACAGATGGAGGATGTAGGAAA
>2.3|1555376|35|NC_022777|CRISPRCasFinder,CRT,PILER-CR
AGTTGTGGAGATTATAGAGATATGCAACATACTGC

CRISPR arrays and Neighbor proteins around NC_022777_2

CRISPR arrays

The CRISPR arrays of NC_022777_2

>merge|NC_022777|2|1555216-1555440|CRISPRCasFinder,CRT,PILER-CR
TGAGGTATACATCCTATGTTAAGGTTCAACGTTACTGTGTATATTGGTACAAAAAGAATAAAAACATTTAAATACATCCTATGTTAAGGTTCAACGGCTTTATACTTATACAGATGGAGGATGTAGGAAAATTTAAATACATCCTATGTTAAGGTTCAACAGTTGTGGAGATTATAGAGATATGCAACATACTGCATTTAAATACATCCTATGTTAAGGTTCAAC

>NC_022777|2|2|1555216-1555440|CRISPRCasFinder
TGAGGTATACATCCTATGTTAAGGTTCAAC	GTTACTGTGTATATTGGTACAAAAAGAATAAAAAC
ATTTAAATACATCCTATGTTAAGGTTCAAC	GGCTTTATACTTATACAGATGGAGGATGTAGGAAA
ATTTAAATACATCCTATGTTAAGGTTCAAC	AGTTGTGGAGATTATAGAGATATGCAACATACTGC
ATTTAAATACATCCTATGTTAAGGTTCAAC

>NC_022777|2|2|1555216-1555440|CRT
TGAGGTATACATCCTATGTTAAGGTTCAAC	GTTACTGTGTATATTGGTACAAAAAGAATAAAAAC
ATTTAAATACATCCTATGTTAAGGTTCAAC	GGCTTTATACTTATACAGATGGAGGATGTAGGAAA
ATTTAAATACATCCTATGTTAAGGTTCAAC	AGTTGTGGAGATTATAGAGATATGCAACATACTGC
ATTTAAATACATCCTATGTTAAGGTTCAAC

>NC_022777|2|2|1555281-1555440|PILER-CR
ATTTAAATACATCCTATGTTAAGGTTCAAC	GGCTTTATACTTATACAGATGGAGGATGTAGGAAA
ATTTAAATACATCCTATGTTAAGGTTCAAC	AGTTGTGGAGATTATAGAGATATGCAACATACTGC
ATTTAAATACATCCTATGTTAAGGTTCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022777.1|WP_023438371.1|1550015_1550255_-|DnaD-domain-protein	unknown	unknown	gnl|CDD|377797
NC_022777.1|WP_023438362.1|1543580_1544597_+|two-component-sensor-histidine-kinase	unknown	unknown	gnl|CDD|225115
NC_022777.1|WP_023438380.1|1559376_1560975_-|acetaldehyde-dehydrogenase-(acetylating)	unknown	unknown	gnl|CDD|131570
NC_022777.1|WP_035109724.1|1549058_1549238_-|YvrJ-family-protein	unknown	unknown	gnl|CDD|378969
NC_022777.1|WP_023438372.1|1550282_1551635_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|273206
NC_022777.1|WP_023438374.1|1552714_1553257_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NC_022777.1|WP_023438373.1|1551647_1552514_-|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438376.1|1556918_1557470_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NC_022777.1|WP_023438379.1|1558368_1558659_-|ethanolamine-utilization-microcompartment-protein-EutM	unknown	unknown	gnl|CDD|132899
NC_022777.1|WP_011099656.1|1556095_1556683_-|HDIG-domain-containing-protein	unknown	unknown	gnl|CDD|225198
NC_022777.1|WP_023438368.1|1548703_1549048_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438375.1|1553634_1554999_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|225212
NC_022777.1|WP_011099658.1|1558726_1559377_-|phosphate-propanoyltransferase	unknown	unknown	gnl|CDD|237899
NC_022777.1|WP_023438381.1|1561009_1561699_-|BMC-domain-containing-protein	unknown	unknown	gnl|CDD|132885
NC_022777.1|WP_023438363.1|1544753_1545440_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224059
NC_022777.1|WP_023438384.1|1562674_1562977_-|BMC-domain-containing-protein	unknown	unknown	gnl|CDD|132895
NC_022777.1|WP_023438382.1|1561729_1562380_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380357
NC_022777.1|WP_045923688.1|1549448_1549991_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|274357
NC_022777.1|WP_023438386.1|1562992_1563841_-|ethanolamine-utilization-protein-EutJ	unknown	unknown	gnl|CDD|237904
NC_022777.1|WP_023438383.1|1562414_1562678_-|EutN/CcmL-family-microcompartment-protein	unknown	unknown	gnl|CDD|377017

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022777.1|WP_023438371.1|1550015_1550255_-|DnaD-domain-protein	gnl|CDD|377797	pfam07261, DnaB_2, Replication initiation and membrane attachment. This family consists of several bacterial replication initiation and membrane attachment (DnaB) proteins, as well as DnaD which is a component of the PriA primosome. The PriA primosome functions to recruit the replication fork helicase onto the DNA. The DnaB protein is essential for both replication initiation and membrane attachment of the origin region of the chromosome and plasmid pUB110 in Bacillus subtilis. It is known that there are two different classes (DnaBI and DnaBII) in the DnaB mutants; DnaBI is essential for both chromosome and pUB110 replication, whereas DnaBII is necessary only for chromosome replication. DnaD has been merged into this family. This family also includes Ftn6, a cyanobacterial-specific divisome component possibly playing a role at the interface between DNA replication and cell division. Ftn6 possesses a conserved domain localized within the N-terminus of the proteins. This domain, named FND, exhibits sequence and structure similarities with the DnaD-like domains pfam04271 now merged into pfam07261.	1.65363e-05
NC_022777.1|WP_023438375.1|1553634_1554999_-|MBL-fold-metallo-hydrolase	gnl|CDD|225212	COG2333, ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only].	5.73097e-87
NC_022777.1|WP_011099658.1|1558726_1559377_-|phosphate-propanoyltransferase	gnl|CDD|237899	PRK15070, PRK15070, phosphate propanoyltransferase.	1.23719e-124
NC_022777.1|WP_035109724.1|1549058_1549238_-|YvrJ-family-protein	gnl|CDD|378969	pfam12841, YvrJ, YvrJ protein family. This family of short proteins are related to B. subtilis YvrJ protein. None of the members of this family have been functionally characterized.	3.78175e-10
NC_022777.1|WP_023438372.1|1550282_1551635_-|AAA-family-ATPase	gnl|CDD|273206	TIGR00665, DnaB, replicative DNA helicase. This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair].	1.93709e-70
NC_022777.1|WP_023438374.1|1552714_1553257_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.9618e-16
NC_022777.1|WP_045923688.1|1549448_1549991_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.24826e-21
NC_022777.1|WP_023438379.1|1558368_1558659_-|ethanolamine-utilization-microcompartment-protein-EutM	gnl|CDD|132899	cd07059, BMC_PduA, 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain. PduA is encoded within the 1,2-propanediol utilization (pdu) operon along with other homologous carboxysome shell proteins PduB, B', J, K, T, and U. PduA is thought to be required for the formation of the outer shell of bacterial pdu polyhedral organelles which are involved in coenzyme B12-dependent degradation of 1,2-propanediol. Although it has been suggested that PduA might form hexamers and further assemble into the flat facets of the polyhedral outer shell of pdu organelles, like PduU does, at present no experimental evidence directly supports this view.	1.04531e-40
NC_022777.1|WP_011099656.1|1556095_1556683_-|HDIG-domain-containing-protein	gnl|CDD|225198	COG2316, COG2316, Predicted hydrolase (HD superfamily) [General function prediction only].	1.57246e-41
NC_022777.1|WP_023438376.1|1556918_1557470_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.74926e-15
NC_022777.1|WP_023438362.1|1543580_1544597_+|two-component-sensor-histidine-kinase	gnl|CDD|225115	COG2205, KdpD, Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms].	8.13119e-40
NC_022777.1|WP_023438381.1|1561009_1561699_-|BMC-domain-containing-protein	gnl|CDD|132885	cd07045, BMC_CcmK_like, Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain. Bacterial micro-compartments are primitive protein-based organelles that sequester specific metabolic pathways in bacterial cells. The prototypical bacterial microcompartment is the carboxysome shell, a bacterial polyhedral organelle which increase the efficiency of CO2 fixation by encapsulating RuBisCO and carbonic anhydrase. They can be divided into two types: alpha-type carboxysomes (alpha-cyanobacteria and proteobacteria) and beta-type carboxysomes (beta-cyanobacteria). Potential functional differences between the two types are not yet fully understood. In addition to these proteins there are several homologous shell proteins including those found in pdu organelles involved in coenzyme B12-dependent degradation of 1,2-propanediol and eut organelles involved in the cobalamin-dependent degradation of ethanolamine. Structure evidence shows that several carboxysome shell proteins and their homologs (Csos1A, CcmK1,2,4, and PduU) exist as hexamers which might further assemble into extended, tightly packed layers hypothesized to represent the flat facets of the polyhedral organelles outer shell. Although it has been suggested that other homologous proteins in this family might also form hexamers and play similar functional roles in the construction of their corresponding organelle outer shells at present no experimental evidence directly supports this view.	4.92446e-37
NC_022777.1|WP_023438363.1|1544753_1545440_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	2.69174e-105
NC_022777.1|WP_023438384.1|1562674_1562977_-|BMC-domain-containing-protein	gnl|CDD|132895	cd07055, BMC_like_2, Bacterial Micro-Compartment (BMC)-like domain 2. BMC like 2 domains exist in cyanobacteria, proteobacteria, and actinobacteria and are homologs of carboxysome shell proteins. They might be encoded from putative organelles involved in unknown metabolic process. Although it has been suggested that these carboxysome shell protein homologs form hexamers and further assemble into the flat facets of the polyhedral bacterial organelles shell at present no experimental evidence exists to directly support this view.	8.46397e-28
NC_022777.1|WP_023438382.1|1561729_1562380_-|cupin-domain-containing-protein	gnl|CDD|380357	cd02228, cupin_EutQ, Clostridium difficile EutQ and related proteins, cupin domain. This family includes bacterial and fungal proteins homologous to ethanolamine utilization protein EutQ found in Clostridium difficile, as well as in other bacteria, including the enteric pathogens Salmonella enterica and Enterococcus faecalis. EutQ is encoded by the eutQ gene which is part of the eut (ethanolamine utilization) operon found to be essential during anoxic growth of S. enterica on ethanolamine and tetrathionate. In C. difficile, inability to utilize ethanolamine results in greater virulence and a shorter time to morbidity in the animal model, suggesting that, in contrast to other intestinal pathogens, the metabolism of ethanolamine can delay the onset of disease. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization. In contrast to the metal-binding catalytic cupins, the EutQ family does not possess the histidine residues that are responsible for metal coordination in the oxidoreductase and epimerase classes of cupins.	1.3197e-27
NC_022777.1|WP_023438383.1|1562414_1562678_-|EutN/CcmL-family-microcompartment-protein	gnl|CDD|377017	pfam03319, EutN_CcmL, Ethanolamine utilisation protein EutN/carboxysome. The crystal structure of EutN contains a central five-stranded beta-barrel, with an alpha-helix at the open end of this barrel (Structure 2HD3). The structure also contains three additional beta-strands, which help the formation of a tight hexamer, with a hole in the center. this suggests that EutN forms a pore, with an opening of 26 Angstrom in diameter on one face and 14 Angstrom on the other face. EutN is involved in the cobalamin-dependent degradation of ethanolamine.	1.17755e-34
NC_022777.1|WP_023438386.1|1562992_1563841_-|ethanolamine-utilization-protein-EutJ	gnl|CDD|237904	PRK15080, PRK15080, ethanolamine utilization protein EutJ; Provisional.	4.28192e-174
NC_022777.1|WP_023438380.1|1559376_1560975_-|acetaldehyde-dehydrogenase-(acetylating)	gnl|CDD|131570	TIGR02518, Acetaldehyde_dehydrogenase_acetylating, acetaldehyde dehydrogenase (acetylating).	0

Protein sequences

>NC_022777.1|WP_023438375.1|1553634_1554999_-|MBL-fold-metallo-hydrolase
MKALTKIGKILVILIILSVIIAISPKLGSIVFTIVPIIYLIYLFKKGPKFKNYNFLLKGLISFFLILVSTTGIGGVFSEFGEEDNKWKQVATVKTDNVDKNNIKENIDSATPINKEVKDNKETKEIKNNEVAGNLKVHYIDVNQGDSILIQQDGHNMLIDAGINATETSVVSYLKNQGVTKLDYVIGTHPHEDHIGGLEKVIDTFQVDKVFMPEINHTTQTFKNVVTSIKNKGLKISTPKVGNSYGLGNARWQILAPVSASYDNLNNYSIVTKLKFGNNSFIFTGDAESLSEGEILQKQLDISSDVINIGHHGSRTSTTQNFLDKINPKYAVISCGKGNKYGHPTQETLNKLKDKGIKVYRTDECSNVIATSDGNNITFNTKPGSYKGVDNTKSTRKPTSKVQPKPVPKATPKPTAKPQPTLPVVKSQPNSKTVHITNTGKKYHRNGCRSLRKK
>NC_022777.1|WP_023438374.1|1552714_1553257_+|helix-turn-helix-transcriptional-regulator
MDKFKLGKNIKNLRKAKGLTQKKLSEELGLSLQSIIKYESGEREPNFETLNKMANIFNVELSILLLDKEESTSTENKIKNECSSIQKKMEDEISNAVKSWLDGSSEEFELEQKKLYEKYFFSLLRWKLKNISTPEEFFTFMFSCCTLDNFPYLSSKDINDLITTFSQLYKMKIYENYIGK
>NC_022777.1|WP_023438373.1|1551647_1552514_-|hypothetical-protein
MEGWIKLHRKLLEKAIWRNCTPSQCKVLITILLMCNYEEQQWIWKGKKFMVKPGEMVTSLNNIARNCGEGITPKIVRNSLDKFQQYGFLKSIGSERGRLITINNWEFYQSIGESVEQNKNSEYYEENERHRAKLGQGVSHWNMEDEKKWVLMEGQSEGKVRATNKKDKNIRINIYSAIFSYWNQKGIIKHRQLTKKIESAMDKALKEYSQDEILEAIDRYSTVYFDKDFYYKHSWTLEKFLRQGNGISNYSDEGIIWINYKRHKEKVETKKNCEGCNIHEQREKYILC
>NC_022777.1|WP_023438372.1|1550282_1551635_-|AAA-family-ATPase
MDILSKMRNIELEQIILGSIILKNSLWIHIEEENIEKDHFYENRHKELFAIMEKLIKDNEVIDMVTLNNYILKKGIENKISISFLSILITNVISTSNFQTYLKELKKYKEKRDIKDIMIYIQSNFHKESEELKEELTKRILNITKEDKKDSGSIREGMDKLLDDLEFRITNGGQDKISGFSTGLRALDLTIDGFEKGDLITVVARSGIGKTTFATSLILNMLRKDYKVAMFSMEMPKEHILKKMAFNHCRVEGDKYKRGELRDEEIQNIVEFVNWIGGKENFFIYNDSNFNSIVWKIKSQLLKKKVDIVFIDYLNKIQGLKENTRDIELNRVTSTLKDIALENNICIVSLTQANRQVDRQQDKRIDLADIKESSSIEQNSDKVISLYRNKKLDNPLYKEKLFNEGKLNYKKPNADYNPDCIEVDVLKCRMGDCKTIACRWSGKHSKISNW
>NC_022777.1|WP_023438371.1|1550015_1550255_-|DnaD-domain-protein
MLKCNKKQEEEVKKICEVFEKNVRPITIIEYEKILNWMKQSSSDLIILAIEEVSKRNIKNTMYIDTYLKLVKDIKMERC
>NC_022777.1|WP_045923688.1|1549448_1549991_-|sigma-70-family-RNA-polymerase-sigma-factor
MGELYKRYKKGDNDAILEIIDNFKPLIFKESRKWKIKCYDYEDLVQHGYLSIIKALNIFKGEPEKFVGYCIKAIKMNYRALLKGEIKHHREIPDEYILDKADNDYLFTLEDEVIAYEKTKELYNALDKLSKSEKHIIKEAYFNNNSVNKIALDSNLTYNKVRYKKFKALKKLQKELKVHI
>NC_022777.1|WP_035109724.1|1549058_1549238_-|YvrJ-family-protein
MFDEIVMLISNVGFPVAVTTYLLVRLDQRLEELTKDFIDLTRVIEAALEHQEREENFKK
>NC_022777.1|WP_023438368.1|1548703_1549048_+|hypothetical-protein
MNIEKLIEELGKSIGKTILNKKEESSKKINIDQMSSTDIFKIIFNKLFREGNYNKAEDLLFDELEKNNSSEVYEIAIEFYNSLLKKTDEELNKRNFSREEIYKGLEDIQKFKVN
>NC_022777.1|WP_023438363.1|1544753_1545440_+|ABC-transporter-ATP-binding-protein
MIILETKNLKKFYGVEPNIVKALDGINLTVEKGDFLSIVGTSGSGKSTLLNMLGGLDTPTSGNVIVRGKELNKLKEEQLTIFRRRNIGFIFQSYNLVPTLNVHENIVLPVDLDGEKVDKPYFNEIINMLALERKLNSLPSQLSGGQQQRVAIARALITKPAIILADEPTGNLDSKTSEDVLALLKRTSEKFNQTIVMITHNNGIAQLADRIVRIEDGKIVGRDLHVSK
>NC_022777.1|WP_023438362.1|1543580_1544597_+|two-component-sensor-histidine-kinase
MKNNMNKETLFLVVITLLYNLFLLLYFKIFLLLILSILMCVIYIFYCYLSIKKVENEVYAFTESINKSFNELINKEYANIFSLNTMDETLIAKINQKMIRLAEISEHESVKGMKGKKELQVLISDISHQVKTPLTNLKMLQCTLLEKELPKEKRIELLLSVGRQLNKLDFLLNSMIKTSRLETGLIQLNKLEENLFETIAEALSGITILAEKKNMNILVKSSEEFLLKHDRKWTAEALFNVLENAVKYSPKGTVIEIQVSRWEISTKIDIIDQGKGIPEEHHGKIFQRFYREEYNNDEEGIGIGLYLTREIIQKQGGYIKVSSTVSKGSTFSIFLPNN
>NC_022777.1|WP_011099656.1|1556095_1556683_-|HDIG-domain-containing-protein
MITRKEAWDLLNEYNKEAFHIQHALTVEGTMKYFAEKLGYEDEVEFWSMVGLLHDLDFEIYPEEHCIKTQEIMRQRGLDEKLIRAAASHGYGLCQGELPKPEHQMEKVLFAVDELTGLIGAAARMRPSKSVMDMEISSLKKKFKDKKFAAGCSRDVIKKGAEMLGWELNKLFEETILAMRSCEAYINDEMEVYNN
>NC_022777.1|WP_023438376.1|1556918_1557470_+|helix-turn-helix-transcriptional-regulator
MNINSIIAENLKTLRTERNLSLGQLAELSGISKVMLSQIEKGDTNPTINTLWKIAKGLKVPYTSLLEQKKHDTYVIKKRNIEAQFTEEGHYRVYCYYTSTPYRNFELFQIEIDEGCSYKSIGHSKKCQEYIMVLEGELTLEINNKIYKLTSDDSISFSASSQHIYINSGNGTLKATITNFYPA
>NC_022777.1|WP_023438379.1|1558368_1558659_-|ethanolamine-utilization-microcompartment-protein-EutM
MKYDALGMIETKGLVGSIEAADAMVKAANVYLIGKEYVGGGLVTVMVRGDVGAVKAATDAGAAAAQRVGELVSVHVIPRPHSEVEVILPSAKETAK
>NC_022777.1|WP_011099658.1|1558726_1559377_-|phosphate-propanoyltransferase
MDNCEELLKLLLEAVKSQGLNTEVNKNSSEIPVGISNRHIHLSQRDLDILFGNGYELVKIKDLSQPGQYACNETVTICGPKGAIEKVRILGPVRGKTQVEVLTGDCIKLGVVPHVRLSGDLKDTSRITIVGPKGSIQVEEGLIVAQRHIHMTPEDAKYLGVHDGEIVSIKFEDLRGGIYNNVAIRANNTSKLECHIDIEEANAMGITSKSKVTIVK
>NC_022777.1|WP_023438380.1|1559376_1560975_-|acetaldehyde-dehydrogenase-(acetylating)
MEKYDKDLYSIQQARNLARLGKVAANKIANYTEEQIDKILRNMVRVAEENAVSLAQMAVEETGFGKVEDKTYKNHLAATILYNSIKDMKTIGVISEDKVNKMIEIAEPVGLIMGIVPSTNPTSTAIFKSIIAIKSRNAIVFSPHPAAAKCTIRAVELMRDAAIEAGAPEDIIASLTNLTMEATNELMKNENVSLIIATGGPGMVKAAYSSGKPAIGVGAGNSPAYIERTANVEKAIRDIISSKSFDYGTICASEQSIICEECNHDAVVEELKKQGGYFMTAEETERVCKLLFKNGHTMNAKFVGRSPQVIANAAGFTVSEDIKVLIGKQNGVGNGNPLSFEKLTTVLAFYTVKDWHEACELSIELLQNGIGHTMSIHTQNDDIVMEFAKKPASRILVNTGGSQGGTGASTGLKPAFTLGCGTWGGSSVSENVTPEYLINKKRVAYGLKDCATLVQNDPTFNCIKTASNCRGVQNQFMNMSPAQIAAAAEVLNKCNDYAKNTGCSNESKEKDANNEELLSLVNQIVAAMKGAN
>NC_022777.1|WP_023438381.1|1561009_1561699_-|BMC-domain-containing-protein
MQALGLIETKGLLAAVEAADVMVKSADVSIIEKTYVGGGLVTISVTGDVGAVKASIEAGAAAVKNLNEEFLVSEHVIPRPHEELESIIGSNNLQEDSSSNEDTSSVENVEKAEVVETTEALEEEQIVEDIYDSKNLKDVDTENKIKENQEKLDEDLDKVNLEKLHKNNVDNLVSKNGLEKIISILNKLKVAKLRSLAGEYKDFGIKVSEISKADKNLLIKKFKLYYEKN
>NC_022777.1|WP_023438382.1|1561729_1562380_-|cupin-domain-containing-protein
MKKLICAKDVEELILKGEKIFYIDGTEIITPSARDLVKNNGIEFTTKPCEIKVQSLENNKALNMDEFDSEMMINFFKKMMDKGILEEILKCLKQKSLPFEAECDPSGLKVIRGNTVKMDVFDTGNPDAKVYFQELFSKKGSKIGAGFLTIEDSKFHLKLNCEEMNYVIEGTLTVEINGKTYTAHAGDVLFLPKDSTVLLKSFAKTKVFYVKYPESL
>NC_022777.1|WP_023438383.1|1562414_1562678_-|EutN/CcmL-family-microcompartment-protein
MILAKLIDTVWATRKAESLSGLKFMLAEEASGTYKGRRFIVADTIGAGIGDRVIVSTGSGARRMLGDDNIPIDAVVIGIIDSDCNLS
>NC_022777.1|WP_023438384.1|1562674_1562977_-|BMC-domain-containing-protein
MDFRIIKSPSNSTKDILKKRMSKNSITDLENADAIGLVQGKFIDMIYASDIAEKAVGVTVEDIRGTCPQHMVLISVLGDTSSVEAALNEIKLKMKEVGAI
>NC_022777.1|WP_023438386.1|1562992_1563841_-|ethanolamine-utilization-protein-EutJ
MSKGNLTFEYCDNMVQKFEEVIKKPILNESSVYYTGVDLGTACVVLAVLDENYEPVAGAFRYADVVRDGMIVDYIGAVKIVRELKEEIEEKLNTELIYAAAAIPPGTDELDSGAIKNVVQAAGFELTRILDEPTAANALLKIQNGAVVDIGGGTTGISILKDGKVVYVVDEATGGTHFSLVISGAYGMSFKEADKFKRDSKNHKEILPILKPVIEKVSSIINNYIKNHDVCEISLVGGTCCLTGIEEIIEKQTKIYTHKPKNPMFVTPLGIALSCTQDIIEE

Crispr_ID: NC_022777_3

• CRISPR_ID: NC_022777_3
• CRISPR_location: 1573835-1574124
• CRISPR_type: TypeI-B
• Repeat_type: III-B
• Spacer_info: 4 spacers
• Cas_protein_info: cas2,cas1,cas4,cas3,cas5,cas7b

Consensus repeat of NC_022777_3

Consensus_repeat	Method
ATTTAAATACAACTCTTGTTATTGTTCAAC	CRISPRCasFinder
ATTTAAATACAACTCTTGTTATTGTTCAAC	CRT
ATTTAAATACAACTCTTGTTATTGTTCAAC	PILER-CR

spacers of NC_022777_3

>3.1|1573865|36|NC_022777|CRISPRCasFinder,CRT
AGATAAATGAATTGTTTAGTTACTTAGAGGAAGGCA
>3.2|1573931|34|NC_022777|CRISPRCasFinder,CRT
GCTTAGGCTAGGAGCTACCTCTTTTTTTATTTTT
>3.3|1573995|34|NC_022777|CRISPRCasFinder,CRT
GTTTTGCAGAGGTTCGAGAAAAACTTAAATATTA
>3.4|1574059|36|NC_022777|CRISPRCasFinder,CRT
TGGTGCTAAATTAACAACTGTTAATCCAAATATAAA
>3.5|1573867|36|NC_022777|PILER-CR
AGATAAATGAATTGTTTAGTTACTTAGAGGAAGGCA
>3.6|1573933|34|NC_022777|PILER-CR
GCTTAGGCTAGGAGCTACCTCTTTTTTTATTTTT
>3.7|1573997|34|NC_022777|PILER-CR
GTTTTGCAGAGGTTCGAGAAAAACTTAAATATTA
>3.8|1574061|36|NC_022777|PILER-CR
TGGTGCTAAATTAACAACTGTTAATCCAAATATAAA

CRISPR arrays and Neighbor proteins around NC_022777_3

CRISPR arrays

The CRISPR arrays of NC_022777_3

>merge|NC_022777|3|1573835-1574124|CRISPRCasFinder,CRT,PILER-CR
TATTAAATACAACTCTTATTATTGTTCAACAGATAAATGAATTGTTTAGTTACTTAGAGGAAGGCAATTTAAATACAACTCTTGTTATTGTTCAACGCTTAGGCTAGGAGCTACCTCTTTTTTTATTTTTATTTAAATACAACTCTTGTTATTGTTCAACGTTTTGCAGAGGTTCGAGAAAAACTTAAATATTAATTTAAATACAACTCTTGTTATTGTTCAACTGGTGCTAAATTAACAACTGTTAATCCAAATATAAAATTTAAATACAACTCTTGTTATTGTTCAAC

>NC_022777|3|3|1573835-1574124|CRISPRCasFinder
TATTAAATACAACTCTTATTATTGTTCAAC	AGATAAATGAATTGTTTAGTTACTTAGAGGAAGGCA
ATTTAAATACAACTCTTGTTATTGTTCAAC	GCTTAGGCTAGGAGCTACCTCTTTTTTTATTTTT
ATTTAAATACAACTCTTGTTATTGTTCAAC	GTTTTGCAGAGGTTCGAGAAAAACTTAAATATTA
ATTTAAATACAACTCTTGTTATTGTTCAAC	TGGTGCTAAATTAACAACTGTTAATCCAAATATAAA
ATTTAAATACAACTCTTGTTATTGTTCAAC

>NC_022777|3|3|1573835-1574124|CRT
TATTAAATACAACTCTTATTATTGTTCAAC	AGATAAATGAATTGTTTAGTTACTTAGAGGAAGGCA
ATTTAAATACAACTCTTGTTATTGTTCAAC	GCTTAGGCTAGGAGCTACCTCTTTTTTTATTTTT
ATTTAAATACAACTCTTGTTATTGTTCAAC	GTTTTGCAGAGGTTCGAGAAAAACTTAAATATTA
ATTTAAATACAACTCTTGTTATTGTTCAAC	TGGTGCTAAATTAACAACTGTTAATCCAAATATAAA
ATTTAAATACAACTCTTGTTATTGTTCAAC

>NC_022777|3|3|1573837-1574124|PILER-CR
TTAAATACAACTCTTATTATTGTTCAACAG	ATAAATGAATTGTTTAGTTACTTAGAGGAAGGCAAT
TTAAATACAACTCTTGTTATTGTTCAACGC	TTAGGCTAGGAGCTACCTCTTTTTTTATTTTTAT
TTAAATACAACTCTTGTTATTGTTCAACGT	TTTGCAGAGGTTCGAGAAAAACTTAAATATTAAT
TTAAATACAACTCTTGTTATTGTTCAACTG	GTGCTAAATTAACAACTGTTAATCCAAATATAAAAT
TTAAATACAACTCTTGTTATTGTTCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_022777.1|WP_023438391.1|1569314_1569611_-|BMC-domain-containing-protein	unknown	unknown	gnl|CDD|132885
NC_022777.1|WP_011099669.1|1569970_1571086_-|membrane-protein	unknown	unknown	gnl|CDD|273359
NC_022777.1|WP_023438392.1|1569717_1569984_-|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438396.1|1575446_1576583_-|cysteine-desulfurase	unknown	unknown	gnl|CDD|224029
NC_022777.1|WP_023438394.1|1572442_1573585_-|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl|CDD|341459
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl|CDD|131641
NC_022777.1|WP_023438388.1|1565330_1566284_-|choline-TMA-lyase-activating-enzyme	unknown	unknown	gnl|CDD|275188
NC_022777.1|WP_172645108.1|1574336_1575413_-|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl|CDD|234664
NC_022777.1|WP_023438393.1|1571529_1572360_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133382
NC_022777.1|WP_023438397.1|1576958_1577771_+|hypothetical-protein	unknown	unknown	gnl|CDD|234750
NC_022777.1|WP_011099665.1|1564937_1565291_-|BMC-domain-containing-protein	unknown	unknown	gnl|CDD|132886
NC_022777.1|WP_011099664.1|1564497_1564941_-|lysine-sensitive-aspartokinase-III	unknown	unknown	gnl|CDD|131580
NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|313108
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl|CDD|187770
NC_022777.1|WP_023438389.1|1566305_1568846_-|choline-trimethylamine-lyase	unknown	unknown	gnl|CDD|275187
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_022777.1|WP_023438390.1|1568984_1569293_-|BMC-domain-containing-protein	unknown	unknown	gnl|CDD|132885

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	1.6e-91	300.8	4.1
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	1.9e-28	94.5	1.0
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	3.3e-47	155.9	10.5
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	4.2e-132	434.9	15.7
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.8e-27	90.2	0.2
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	2.3e-50	165.6	7.4

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022777.1|WP_023438391.1|1569314_1569611_-|BMC-domain-containing-protein	gnl|CDD|132885	cd07045, BMC_CcmK_like, Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain. Bacterial micro-compartments are primitive protein-based organelles that sequester specific metabolic pathways in bacterial cells. The prototypical bacterial microcompartment is the carboxysome shell, a bacterial polyhedral organelle which increase the efficiency of CO2 fixation by encapsulating RuBisCO and carbonic anhydrase. They can be divided into two types: alpha-type carboxysomes (alpha-cyanobacteria and proteobacteria) and beta-type carboxysomes (beta-cyanobacteria). Potential functional differences between the two types are not yet fully understood. In addition to these proteins there are several homologous shell proteins including those found in pdu organelles involved in coenzyme B12-dependent degradation of 1,2-propanediol and eut organelles involved in the cobalamin-dependent degradation of ethanolamine. Structure evidence shows that several carboxysome shell proteins and their homologs (Csos1A, CcmK1,2,4, and PduU) exist as hexamers which might further assemble into extended, tightly packed layers hypothesized to represent the flat facets of the polyhedral organelles outer shell. Although it has been suggested that other homologous proteins in this family might also form hexamers and play similar functional roles in the construction of their corresponding organelle outer shells at present no experimental evidence directly supports this view.	8.2144e-32
NC_022777.1|WP_011099669.1|1569970_1571086_-|membrane-protein	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	0.00632714
NC_022777.1|WP_023438390.1|1568984_1569293_-|BMC-domain-containing-protein	gnl|CDD|132885	cd07045, BMC_CcmK_like, Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain. Bacterial micro-compartments are primitive protein-based organelles that sequester specific metabolic pathways in bacterial cells. The prototypical bacterial microcompartment is the carboxysome shell, a bacterial polyhedral organelle which increase the efficiency of CO2 fixation by encapsulating RuBisCO and carbonic anhydrase. They can be divided into two types: alpha-type carboxysomes (alpha-cyanobacteria and proteobacteria) and beta-type carboxysomes (beta-cyanobacteria). Potential functional differences between the two types are not yet fully understood. In addition to these proteins there are several homologous shell proteins including those found in pdu organelles involved in coenzyme B12-dependent degradation of 1,2-propanediol and eut organelles involved in the cobalamin-dependent degradation of ethanolamine. Structure evidence shows that several carboxysome shell proteins and their homologs (Csos1A, CcmK1,2,4, and PduU) exist as hexamers which might further assemble into extended, tightly packed layers hypothesized to represent the flat facets of the polyhedral organelles outer shell. Although it has been suggested that other homologous proteins in this family might also form hexamers and play similar functional roles in the construction of their corresponding organelle outer shells at present no experimental evidence directly supports this view.	4.67179e-33
NC_022777.1|WP_023438396.1|1575446_1576583_-|cysteine-desulfurase	gnl|CDD|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	0
NC_022777.1|WP_023438394.1|1572442_1573585_-|iron-containing-alcohol-dehydrogenase	gnl|CDD|341459	cd08180, PDD, 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism. 1,3-propanediol dehydrogenase (PPD) plays a role in glycerol metabolism of some bacteria in anaerobic conditions. In this degradation pathway, glycerol is converted in a two-step process to 1,3-propanediol (1,3-PD) which is then excreted into the extracellular medium. The first reaction involves the transformation of glycerol into 3-hydroxypropionaldehyde (3-HPA) by a coenzyme B-12-dependent dehydratase. The second reaction involves the dismutation of the 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol by the NADH-linked 1,3-propanediol dehydrogenase (PPD). The enzyme requires iron ion for its function. Because many genes in this pathway are present in the propanediol utilization (pdu) operon, they are also named pdu genes. PPD is a member of the iron-containing alcohol dehydrogenase superfamily. The PPD structure has a dehydroquinate synthase-like fold.	2.12677e-180
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.17517e-60
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	gnl|CDD|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.0638e-96
NC_022777.1|WP_023438388.1|1565330_1566284_-|choline-TMA-lyase-activating-enzyme	gnl|CDD|275188	TIGR04395, putative_pyruvate_formate-lyase_activating_enzyme, choline TMA-lyase-activating enzyme. Members of this family are CutD, a radical enzyme that serves as an activase for choline TMA-lyase, CutC. CutC is a glycyl radical enzyme related to pyruvate formate-lyase, and this enzyme, CutD, is related to pyruvate formate-lyase activase. [Energy metabolism, Amino acids and amines].	0
NC_022777.1|WP_172645108.1|1574336_1575413_-|tRNA-2-thiouridine(34)-synthase-MnmA	gnl|CDD|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_022777.1|WP_023438393.1|1571529_1572360_-|MerR-family-transcriptional-regulator	gnl|CDD|133382	cd01107, HTH_BmrR, Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	4.10036e-38
NC_022777.1|WP_023438397.1|1576958_1577771_+|hypothetical-protein	gnl|CDD|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	0.000256269
NC_022777.1|WP_011099665.1|1564937_1565291_-|BMC-domain-containing-protein	gnl|CDD|132886	cd07046, BMC_PduU-EutS, 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain. PduU encapsulates several related enzymes within a shell composed of a few thousand protein subunits. PduU exists as a hexamer which might further assemble into the flat facets of the polyhedral outer shell of the pdu organelle. This proteinaceous noncarboxysome microcompartment is involved in coenzyme B12-dependent degradation of 1,2-propanediol. The core of PduU is related to the typical BMC domain and its natural oligomeric state is a cyclic hexamer. Unlike other typical BMC domain proteins, the 3D topology of PduU reveals a circular permuted variation on the typical BMC fold which leads to several unique features. The exact functions related to those unique features are still not clear. Another difference is the presence of a deep cavity on one side of the hexamer as well as an intermolecular six-stranded beta barrel that seems to block the central pore that is present in other BMC domain proteins. EutS proteins included in this CD are sequence homologs of PduU. They are encoded within eut operon and may be required for the formation of the outer shell of bacterial eut polyhedral organelles which are involved in the cobalamin-dependent degradation of ethanolamine. Although it has been suggested that EutS might also form hexamers and play similar functional roles in the construction of the eut organelle outer shell at present no experimental evidence directly supports this view.	3.32069e-53
NC_022777.1|WP_011099664.1|1564497_1564941_-|lysine-sensitive-aspartokinase-III	gnl|CDD|131580	TIGR02528, Ethanolamine_utilization_protein_EutP, ethanolamine utilization protein, EutP. This protein is found within operons which code for polyhedral organelles containing the enzyme ethanolamine ammonia lyase. The function of this gene is unknown, although the presence of an N-terminal GxxGxGK motif implies a GTP-binding site. [Energy metabolism, Amino acids and amines].	3.9617e-26
NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase	gnl|CDD|313108	pfam09820, AAA-ATPase_like, Predicted AAA-ATPase. This family contains many hypothetical bacterial proteins. This family was previously the N-terminal part of the Pfam DUF1703 (pfam08011) family before it was split into two. This region is predicted to be an AAA-ATPase domain.	5.17626e-07
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.04177e-29
NC_022777.1|WP_023438389.1|1566305_1568846_-|choline-trimethylamine-lyase	gnl|CDD|275187	TIGR04394, putative_formate_C-acetyltransferase, choline trimethylamine-lyase. Members of this family, homologs to pyruvate formate-lyases and benzylsuccinate synthases, are glycine radical enzymes that appear to act as choline TMA-lyase, that is, to perform a C-N bond cleavage turning choline into trimethylamine (TMA) plus acetaldehyde. The gene symbol is cutC, for choline utilization. The activase, CutD, is a radical SAM enzyme. [Energy metabolism, Amino acids and amines].	0
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.13188e-163
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.34287e-28
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.41443e-49

Protein sequences

>NC_022777.1|WP_023438394.1|1572442_1573585_-|iron-containing-alcohol-dehydrogenase
MKEFSINTDVYFGEGSLDRLNEIKNKRVLIVCDKFMETSGMVTKVQQKLTDCEVTIYSDIVPDPSVEVIASGIQKLQSCNAQIIIALGGGSSIDGAKAIKEYSKKVTGKTINIEEFYAIPTTSGTGSEVTEYAVITNKQEGLKYAITDKSLLPTVAILDPQLVKSVPKAITADTGMDVITHALEAYVSKNATDFSDALAEKAFTLAFRFLPQAYADGEDIIAREKLHNASCLAGMAFNAAGLGITHSLAHAVGGKLHISHGRSNAIILPYVVEYNANLNKESFNAEYSIAAKKYQRLAKLLKLHAPNVTIGVNNLIKSIVKLQNTLMIPQTLKQQREDINLDETSKEEIINAALRDVCTTSNPRETKKEDFLKILDKVLG
>NC_022777.1|WP_023438393.1|1571529_1572360_-|MerR-family-transcriptional-regulator
MKEELYSIGKVGEICKITKKALRYYDKMDILSPDKVSDESGYRYYSKKTLLSVPMIKYYKQSGFKLEEMKVFLEGETYDFFHKSFRNKIDELKELEKEINLKIRSVKDWDDLIVEAQNVIENNVCDVAIKYIDNKTLTFLDQEFKYDYMDSIINIEFTNYIDSIENAITGPVIIRFPCHEDKMNGKCTKMRIMQETILKCKEELSVEFGGWMAAACYHIGPHETISDTYKKIKEWTKEHGYICFEECYERYVTDYWTTKNTDKFVTEILIKISRER
>NC_022777.1|WP_011099669.1|1569970_1571086_-|membrane-protein
MSENSKTVSLEAIAAKKKLSSDFFKKGISLALFSGLAYGLYTAFLTMGMTKGVWGDWYGDNTAGLSVFVIAYLLAALGNAINDTCSAIWSLLYAVVKGKFGDFLRCINTKPGRIMILAALIGGPIASTAYVIALQMAGSIVVPISALCPAIAAILGKVLYKQELNKRMAFGIVICVCASFLIGSTGFTSDGISRNTLLGLLIAIIAALGWGFEGCVAGYGTAMIDPEIGICIRQVTAGIADLCILLPVLGMMAGGINISVDLTMQAFTSAPAMIWFTLSGLLTFMTFMTWYAGNSMCGAGLGTACNGTYSFFGPLFCLLVLGVYGGMDGWALPTVAWIGAVVMIIGILIISMNPLDLFKRKKMEVDVDETA
>NC_022777.1|WP_023438392.1|1569717_1569984_-|hypothetical-protein
MKPLNYAILKHFTKVPEACVDDVIEALKGEYGHFKALNRKAVTNALMTAEANGLIEEVRFDLDENKQLRVYYHAHKEGADTINKYIPD
>NC_022777.1|WP_023438391.1|1569314_1569611_-|BMC-domain-containing-protein
MRYYGDEALGLVETIGLVPALEAADKMLKAANVELISYENIGSTLVTIMVKGDVAAVKASVEAGAKAAAAIGKLTAHNVMPRPIREVGDIVSVHDIDL
>NC_022777.1|WP_023438390.1|1568984_1569293_-|BMC-domain-containing-protein
MARYRALGLIETFGLVFALEAADAMCKAANVELIGYENVASGYISVLVSGDVGACRSAVDAGVAAVNGMEGGNLYSSIVIPSPHEDLEKIIKRYSITTLIPE
>NC_022777.1|WP_023438389.1|1566305_1568846_-|choline-trimethylamine-lyase
MDIREFSNMLMEATKNMSDEERNGLMNMFQSISKEIRKEEKVTPNVVFNNNGEIPDGMTERLIKLKENYMKQVPSITTHRARAITKIAKENPGVPKSVLRGKCFKYCCETAPLVIQDNELIVGAPNGKPRAGAFSPDIAWRWMEDEIDTIANRPQDPFYISEEDKKIMREELFPYWKGKSVDEYCEDQYREAGVWELSGESFVSDCSYHAVNGGGDSNPGYDVILMKKGMLDIKREAEEKLASLSYERPEDIEKIYFYKSIIDTAEGVMIYAKRMSDYAAELAAKETDPKRKAELQKISEVNARVPAHKPSTFWEAIQAVWTIESLLVVEENQTGMSIGRVDQYMYPFYKSDIESGRMTDFEAFELAGCMLIKMSEMMWITSEGGSKFFAGYQPFVNMCVGGVTREGRDATNELTYLLMDAVRHVKIYQPSLACRIHKGSPQKYLKKIVDVIRAGMGFPACHFDDVHIKMMLAKGVSIEDARDYCLMGCVEPQKAGRLYQWTSTGYTQWPICIELVLNHGVPLWYGKQVCPDMGDLSQFKTYEQFEGAVREQIKYITKWTAVATTISQRVHRELAPKPLMSMMYEGCMEKGRGVEAGGAMYNFGPGVVWSGLATYTDSMAAIKKLVFEEKKYTLEELSEALKADFVGYERLRKDCLEAPKYGNDDDYADYIAADLVNFTEQEHRKYKTLYSVLSHGTLSISNNTPFGQMTGATANGRRAWMPLSDGISPSQGSDFKGPTSIIKSVSKISCEDMNIGMVHNFKLMSGLLDTPEGEQGIIALLRSACALQLGEIQFNYLDNETLIEAQKHPEQYRDLIVRVAGYSAFFVELCKDVQDEIISRTMLTHF
>NC_022777.1|WP_023438388.1|1565330_1566284_-|choline-TMA-lyase-activating-enzyme
MSNGNLGVIKEKATVFNIQKYSIYDGDGIRTLVFFQGCPLRCKWCSNPEGLIKKHRVMFKSNLCVNCGACVSVCPVSIHTLSNETLKHEINRNIDCIGCGKCKDACLKSAISIVGEEKTISELLKIVEEDRVFYEMSGGGVTLGGGEVLMQPKAASSLLMACKQEGINTAIETCGYTNLETILKVAESVDLFLFDIKHINPDRHFELTGVRNEQILENLQELLRRKYNVKIRMPLLKDINNSKEEIEATMEFLTPYKDYKNFKGIDLLPYHKMGVNKYNQLGIEYPIKGDPSLNDEELDRIEEWIKKYDLHVKVIRH
>NC_022777.1|WP_011099665.1|1564937_1565291_-|BMC-domain-containing-protein
MGDFENRQIQRVIQESVPGKQITIAHVIASPMADIYERLGIDECGAIGILTLSPFETAIIAADIATKASDVEIGFLDRFTGSVVISGDVQSVETALNAVNNTLKNMLGFTPALITRT
>NC_022777.1|WP_011099664.1|1564497_1564941_-|lysine-sensitive-aspartokinase-III
MIKKRIMVIGSSGSGKTTIVNALNDYNGPLRRTPDLIYGKNTIDVPGAYIENPWMYKHIIALAQNSASCIVILVDQSNCTEVYPHGFAKSFRCPVIGVVTKCDLMPENKEKCLGQLKDIGVVEPYFHISLKTGIDALKKYLLKKCKE
>NC_022777.1|WP_172645108.1|1574336_1575413_-|tRNA-2-thiouridine(34)-synthase-MnmA
MNILKKKVLVGMSGGVDSSVAAYLLKEQGYEVIGATMQIWQDDKEFIEREGGCCSLSAVADARRVANKIGIPFYVMNFKDAFKKNVIDYFVDEYMEGRTPNPCVACNKFIKFSSFLDKAMNLGIDYVATGHYAIIEKQNNRYIIRKSEDDKKDQTYALYNLTQFQLERTLMPCGRYKKSEIREIAKKIGLRVHNKKDSQEICFIPDNDHGKYIKNRFPSKVRQGNFVDKSGNVLGTHKGIVYYTIGQRKGLDIALGKPMYVVDINPFRNEVVLGNLDDLLNTELIAKDVNYIPFDNLKEPMEVEAKIRYSQIPSKAVITPMEDGRVKVNFNEKQRAITKGQSVVFYKGDLLIGGGIIE
>NC_022777.1|WP_023438396.1|1575446_1576583_-|cysteine-desulfurase
MKKNIYMDYAATTYIKKEVIEAMMPYLTEYYANPSSVYNMSNNLKIVIDEAKEEIADFIGATPEEVFFTSGGTEGNNWAIKGIAYANEEKGKHIITSSIEHPAVLNSCKYLKEKGFEITFLPVDSYGKVDLEKLEKSIRNDTILVSIMAANNEIGTIQHIKSIGEICKRHKVLFHTDAVQALGQISINAEEMDIDLMTITAHKIYGPKGIGALYIKKGTKIENILHGGSQERGKRPGTENTAAIVGFKKAVSLLKENGLEESKRIEKLRDKFIKGLLQIENTKINGAMGKERLKGNVNVSFKNIDGELLLMLLDREGIYASAGSACSAGSIDASHVLVALGLEDEFLKGTIRFTLGARNTEEEVDFVLEKLNQLIKKI
>NC_022777.1|WP_023438397.1|1576958_1577771_+|hypothetical-protein
MFKSLSKKVIISVVILIVVLLGVLGMKNYNKSKDYKNLVTTANEYMNEKDYDKAMDKFKESLDYKKDQKAEEKLEECKNELINLSKEALKNKEYEKADNYLNVLLKHDGKNEEAIKMKNTIKDEIQKSKEEEEIKKAIEKEKREQELKKQMDKEEQAKKKTGITEQNKKKEVKENNKITKEKAESLVQPLKNKNEEIRYLGTRQVPEIPAKSTPYKKFPKEIENKKVYIFDIAVVYNSDSKATIGRYYVDFSGNIYKDTYPSNLECVKVK
>NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase
MKKRFNVTGTCIPERHYMVDISNKLDSILKLVNNEEYFIINRPRQYGKTTTLYMLERYLNKFKDYLVISISFEGIGDLIFQDEKVFSKEFLQIMSDSLLLNSQALSECLEEQKPHVENFIDLSRVITKFIVKAKRKVVLMIDEVDKSSNNQLFLSFLGLLRNKYLLRNVGKDYTFHNVILAGVHDVKSLKLKIRPDEEHKYNSPWNIASDFDVDMSFSIDEIKTMLDDYVENKEVNLDKEYFAEKIYFYTSGYPFLVSKLCKIVDEKIMVKDELKWEKEYLQIAVKELLKESNTNFDSLIKNIENNKDLQELVRKIILDGYEITYNEDNPLITMGVTYGIFKNSHGKVKIHNRIYEQRIYNYMISLIETKINLGFYTERERYLKPNGDLDIKKVLKKFQEFMKHEYSQKREGFLEEDGRLVFLAFLSPIINGAGFAFKEVQGGEEKRFDIVITYNKKMYILELKIWRGEEYHKKGLKQLVEYLNQYGLEEGYLLIFDFRKATNLIGQVEETHINAEDNIKKIIGVYC
>NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2
MSKNFNYNYAFVFYDVNEKRVNRVFKTCKKYLSHFQKSVFRGELTPANFILLKKDLNKVINEDEDFICIIKLMNNKVYDEEILGNPHSCTGEDLIL
>NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MGSTRYITSVGELKRKDNSLCFRKNNKNVYIPVENTKEIYCMSEVNINSKLLDFLSQNNIIMHFFNYYEGYSGTFYPREHYNSGKLLVKQVETYENRRLEVAKSIVEAIGDNIYELLYHYYKHDKKEVKETLDWIKNHSKTNLKKANDIKQIMQVEGETWQRFYGEFKNILPEEFVMNKRVKRPPDNPINALISFGNTLLYGKTITAIYNTHLDQRISFLHEPSEGRFSLSLDISEAFKPVIVFKTIFDLVNNKRIQVSKHFDKKLNYCLLNDEGRNIFITAFEERMESIFLNEKLKRKISYKTAIKLDCYKLIKFILENKEFKPFSLKERM
>NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4
MKVNGTLINYYFHCKRQCWLHGNRINLEDNSQDVKIGKAIHEVKKEKGKQTEISIDNIKIDKITKDYLTEVKKSDSDIEAAKWQLLLYLKVLKDKGIERKGKLEFIEKNKSKSTIIIELDENNLSELEDVIKNIENLLIQENPPEVINESKCKKCAYFEYCYI
>NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3
MYFKNIEKVNLKDVINKSDKIYAHIGNGKKETLKEHLDLSIKYLCKIYESKSLYNVFLKIENNFLEKFSIEGKEFYRKMLLNTIYMHDLGKINCNFQYRKMGNKEFENEEGLKFNNSNHSMLSSIIYINYFFREMGNLKHKEDREFLIVFLLLNSYIISKHHGSLDSFSEFRKRLVENGEEGKRLYTEQMPIFNKIYKEKIFFNENKLNRIFEKYKLILEDETEKNKGFSIELYIYERFLASLLLSCDYYSTSEFKNQKEVEEFGEIKDIEKFYQSFKNTEVYNWIRKYEKNDYGKTDDFSNIDDINVLRNELFLDAEKTMVSNIDKDIFYLEAPTGSGKSNVSFNLSFKMVERFKEINKIFYVYPFNTLVEQNIKTLEKIFKNNEIMKDIAIINSVVPIKIKSSKDNKIKEIDTNEESDILNEDYERALLDRQFLHYPIVLTTHVSIFNYLFGTSKDNLFPLCQIANSIIVLDEIQSYKNRIWKEIITFLACYSRLLNIKIIIMSATLPNLNKLVDGEIKTVNLIENRKKYFENPIFKNRVMVDFSLLEEKENIKEVLFNNVIKNTKAPNKNILVEFITKESAMDFYEKLKDYNKYLQESEKREIELITGDDNRVDRNRIIDKIKSQKNIILVATQVIEAGVDIDMDIGYKDISMLDSEEQFLGRINRSCKNDAQGIVYFFDLDSASNIYKSDIRKEKNINLNFPKIREILINKNFEEFYDYVIKELNKKAGEHNDSSFQTFFLDKIKTLNFKGIEERMKLIDELYKNSVFLNRNITLENEEELCGEDVWNEYIAILKNNKLDYAEKKIKLSQVTANLNYFIYQVPSNDFIYEDRIGDIYYIGDGEKYFEDGKFDRKKFKSIIVDFI
>NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5
MDALKFSLSGRTAFFKKPDVNSFYYFTYGNIHKVALLGILGAICGYGGYNRQCLNKEQIYPEFYGKLKDINIGIVPKNEKGYIDKKIQVFNNSVGYASKELGGNLIVKEQWLENPKWDIYILMDENVPKDLEDRLLNFKFKYIPYLGKNDHMANITDVEYLENIEKLDNTNKLDSIFIKDKYEIQKLDNDLFDMLNDSYKDVCEYKYEEMLPVSLDETTNKYNLETFIYTNSKLKSLTESKTYQCDSKNIFFF
>NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7
MGMNKRVYGVLGIVSRMSNWNADFTGYPKTTSSGDVFGSDKAFKYPMKKMWENGGEKVLYIKSIKFQENKKKERELIPRTLKERYEYIFDVEDLKKNKDSEEVLKNLFTAIDVKNFGATFAEEGNNISITGAVQIGQGFNKYKETYAEEQQILSPFRDPNQKEKSKDGEEAKSSTLGTKIVSNEAHYFYPFVVNPSSYNQFEEIGVTNGYTEEDYKKFKEASMIAATSFNTNSKIGCENEFALFVETKEDLYLPDLSQYVDFEKVEDKNIITLSCSELLNSFEDEIENIEIYYNPYTTEIKLDEIKKAKKFNIFTKKEV

Crispr_ID: NC_022777_4

• CRISPR_ID: NC_022777_4
• CRISPR_location: 1578188-1578348
• CRISPR_type: TypeI-B
• Repeat_type: III-B
• Spacer_info: 2 spacers
• Cas_protein_info: cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6

Consensus repeat of NC_022777_4

Consensus_repeat	Method
ATTTAAATACATCCTATGTTAAGGTTCAACA	PILER-CR
ATTTAAATACATCCTATGTTAAGGTTCAAC	CRISPRCasFinder

spacers of NC_022777_4

>4.1|1578219|33|NC_022777|PILER-CR
AAAAGCTGTTAGAAGTATAGCTTGTTCACCATC
>4.2|1578283|35|NC_022777|PILER-CR
CTTATGCGTAGTTTCTATATTCCAGTTCTTTTCTT
>4.3|1578218|34|NC_022777|CRISPRCasFinder
AAAAAGCTGTTAGAAGTATAGCTTGTTCACCATC
>4.4|1578282|36|NC_022777|CRISPRCasFinder
ACTTATGCGTAGTTTCTATATTCCAGTTCTTTTCTT

CRISPR arrays and Neighbor proteins around NC_022777_4

CRISPR arrays

The CRISPR arrays of NC_022777_4

>merge|NC_022777|4|1578188-1578348|PILER-CR,CRISPRCasFinder
ATTTAAATACATCCTATGTTAAGGTTCAACAAAAAGCTGTTAGAAGTATAGCTTGTTCACCATCATTTAAATACATCCTATGTTAAGGTTCAACACTTATGCGTAGTTTCTATATTCCAGTTCTTTTCTTATTTAAATACATCCTATGTTAAGGTTCAACC

>NC_022777|4|4|1578188-1578348|PILER-CR
ATTTAAATACATCCTATGTTAAGGTTCAACA	AAAAGCTGTTAGAAGTATAGCTTGTTCACCATC
ATTTAAATACATCCTATGTTAAGGTTCAACA	CTTATGCGTAGTTTCTATATTCCAGTTCTTTTCTT
ATTTAAATACATCCTATGTTAAGGTTCAACC

>NC_022777|4|4|1578188-1578347|CRISPRCasFinder
ATTTAAATACATCCTATGTTAAGGTTCAAC	AAAAAGCTGTTAGAAGTATAGCTTGTTCACCATC
ATTTAAATACATCCTATGTTAAGGTTCAAC	ACTTATGCGTAGTTTCTATATTCCAGTTCTTTTCTT
ATTTAAATACATCCTATGTTAAGGTTCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_022777.1|WP_023438391.1|1569314_1569611_-|BMC-domain-containing-protein	unknown	unknown	gnl|CDD|132885
NC_022777.1|WP_011099669.1|1569970_1571086_-|membrane-protein	unknown	unknown	gnl|CDD|273359
NC_022777.1|WP_023438392.1|1569717_1569984_-|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438396.1|1575446_1576583_-|cysteine-desulfurase	unknown	unknown	gnl|CDD|224029
NC_022777.1|WP_023438394.1|1572442_1573585_-|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl|CDD|341459
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl|CDD|131641
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl|CDD|188234
NC_022777.1|WP_172645108.1|1574336_1575413_-|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl|CDD|234664
NC_022777.1|WP_023438393.1|1571529_1572360_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133382
NC_022777.1|WP_023438397.1|1576958_1577771_+|hypothetical-protein	unknown	unknown	gnl|CDD|234750
NC_022777.1|WP_023438408.1|1589704_1589851_-|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|313108
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl|CDD|187770
NC_022777.1|WP_023438389.1|1566305_1568846_-|choline-trimethylamine-lyase	unknown	unknown	gnl|CDD|275187
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_022777.1|WP_023438390.1|1568984_1569293_-|BMC-domain-containing-protein	unknown	unknown	gnl|CDD|132885

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	1.6e-91	300.8	4.1
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	cas8b1	mkCas0106_cas8b1_CAS-I-B	9.1e-190	627.1	73.3
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	1.9e-28	94.5	1.0
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	3.3e-47	155.9	10.5
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	2.1e-23	78.4	8.7
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	4.2e-132	434.9	15.7
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.8e-27	90.2	0.2
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	2.3e-50	165.6	7.4

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022777.1|WP_023438391.1|1569314_1569611_-|BMC-domain-containing-protein	gnl|CDD|132885	cd07045, BMC_CcmK_like, Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain. Bacterial micro-compartments are primitive protein-based organelles that sequester specific metabolic pathways in bacterial cells. The prototypical bacterial microcompartment is the carboxysome shell, a bacterial polyhedral organelle which increase the efficiency of CO2 fixation by encapsulating RuBisCO and carbonic anhydrase. They can be divided into two types: alpha-type carboxysomes (alpha-cyanobacteria and proteobacteria) and beta-type carboxysomes (beta-cyanobacteria). Potential functional differences between the two types are not yet fully understood. In addition to these proteins there are several homologous shell proteins including those found in pdu organelles involved in coenzyme B12-dependent degradation of 1,2-propanediol and eut organelles involved in the cobalamin-dependent degradation of ethanolamine. Structure evidence shows that several carboxysome shell proteins and their homologs (Csos1A, CcmK1,2,4, and PduU) exist as hexamers which might further assemble into extended, tightly packed layers hypothesized to represent the flat facets of the polyhedral organelles outer shell. Although it has been suggested that other homologous proteins in this family might also form hexamers and play similar functional roles in the construction of their corresponding organelle outer shells at present no experimental evidence directly supports this view.	8.2144e-32
NC_022777.1|WP_011099669.1|1569970_1571086_-|membrane-protein	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	0.00632714
NC_022777.1|WP_023438390.1|1568984_1569293_-|BMC-domain-containing-protein	gnl|CDD|132885	cd07045, BMC_CcmK_like, Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain. Bacterial micro-compartments are primitive protein-based organelles that sequester specific metabolic pathways in bacterial cells. The prototypical bacterial microcompartment is the carboxysome shell, a bacterial polyhedral organelle which increase the efficiency of CO2 fixation by encapsulating RuBisCO and carbonic anhydrase. They can be divided into two types: alpha-type carboxysomes (alpha-cyanobacteria and proteobacteria) and beta-type carboxysomes (beta-cyanobacteria). Potential functional differences between the two types are not yet fully understood. In addition to these proteins there are several homologous shell proteins including those found in pdu organelles involved in coenzyme B12-dependent degradation of 1,2-propanediol and eut organelles involved in the cobalamin-dependent degradation of ethanolamine. Structure evidence shows that several carboxysome shell proteins and their homologs (Csos1A, CcmK1,2,4, and PduU) exist as hexamers which might further assemble into extended, tightly packed layers hypothesized to represent the flat facets of the polyhedral organelles outer shell. Although it has been suggested that other homologous proteins in this family might also form hexamers and play similar functional roles in the construction of their corresponding organelle outer shells at present no experimental evidence directly supports this view.	4.67179e-33
NC_022777.1|WP_023438396.1|1575446_1576583_-|cysteine-desulfurase	gnl|CDD|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	0
NC_022777.1|WP_023438394.1|1572442_1573585_-|iron-containing-alcohol-dehydrogenase	gnl|CDD|341459	cd08180, PDD, 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism. 1,3-propanediol dehydrogenase (PPD) plays a role in glycerol metabolism of some bacteria in anaerobic conditions. In this degradation pathway, glycerol is converted in a two-step process to 1,3-propanediol (1,3-PD) which is then excreted into the extracellular medium. The first reaction involves the transformation of glycerol into 3-hydroxypropionaldehyde (3-HPA) by a coenzyme B-12-dependent dehydratase. The second reaction involves the dismutation of the 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol by the NADH-linked 1,3-propanediol dehydrogenase (PPD). The enzyme requires iron ion for its function. Because many genes in this pathway are present in the propanediol utilization (pdu) operon, they are also named pdu genes. PPD is a member of the iron-containing alcohol dehydrogenase superfamily. The PPD structure has a dehydroquinate synthase-like fold.	2.12677e-180
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.45511e-22
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.17517e-60
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	gnl|CDD|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.0638e-96
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	gnl|CDD|188234	TIGR02591, cas_Csh1, CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI. This domain is found in the C-terminal 2/3 of a family of CRISPR associated proteins of the Hmari subtype. Except for the two sequences from halophilic archaea this domain contains a pair of CXXC motifs.	1.46816e-84
NC_022777.1|WP_172645108.1|1574336_1575413_-|tRNA-2-thiouridine(34)-synthase-MnmA	gnl|CDD|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_022777.1|WP_023438393.1|1571529_1572360_-|MerR-family-transcriptional-regulator	gnl|CDD|133382	cd01107, HTH_BmrR, Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	4.10036e-38
NC_022777.1|WP_023438397.1|1576958_1577771_+|hypothetical-protein	gnl|CDD|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	0.000256269
NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase	gnl|CDD|313108	pfam09820, AAA-ATPase_like, Predicted AAA-ATPase. This family contains many hypothetical bacterial proteins. This family was previously the N-terminal part of the Pfam DUF1703 (pfam08011) family before it was split into two. This region is predicted to be an AAA-ATPase domain.	5.17626e-07
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.04177e-29
NC_022777.1|WP_023438389.1|1566305_1568846_-|choline-trimethylamine-lyase	gnl|CDD|275187	TIGR04394, putative_formate_C-acetyltransferase, choline trimethylamine-lyase. Members of this family, homologs to pyruvate formate-lyases and benzylsuccinate synthases, are glycine radical enzymes that appear to act as choline TMA-lyase, that is, to perform a C-N bond cleavage turning choline into trimethylamine (TMA) plus acetaldehyde. The gene symbol is cutC, for choline utilization. The activase, CutD, is a radical SAM enzyme. [Energy metabolism, Amino acids and amines].	0
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.13188e-163
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.34287e-28
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.41443e-49

Protein sequences

>NC_022777.1|WP_023438397.1|1576958_1577771_+|hypothetical-protein
MFKSLSKKVIISVVILIVVLLGVLGMKNYNKSKDYKNLVTTANEYMNEKDYDKAMDKFKESLDYKKDQKAEEKLEECKNELINLSKEALKNKEYEKADNYLNVLLKHDGKNEEAIKMKNTIKDEIQKSKEEEEIKKAIEKEKREQELKKQMDKEEQAKKKTGITEQNKKKEVKENNKITKEKAESLVQPLKNKNEEIRYLGTRQVPEIPAKSTPYKKFPKEIENKKVYIFDIAVVYNSDSKATIGRYYVDFSGNIYKDTYPSNLECVKVK
>NC_022777.1|WP_023438396.1|1575446_1576583_-|cysteine-desulfurase
MKKNIYMDYAATTYIKKEVIEAMMPYLTEYYANPSSVYNMSNNLKIVIDEAKEEIADFIGATPEEVFFTSGGTEGNNWAIKGIAYANEEKGKHIITSSIEHPAVLNSCKYLKEKGFEITFLPVDSYGKVDLEKLEKSIRNDTILVSIMAANNEIGTIQHIKSIGEICKRHKVLFHTDAVQALGQISINAEEMDIDLMTITAHKIYGPKGIGALYIKKGTKIENILHGGSQERGKRPGTENTAAIVGFKKAVSLLKENGLEESKRIEKLRDKFIKGLLQIENTKINGAMGKERLKGNVNVSFKNIDGELLLMLLDREGIYASAGSACSAGSIDASHVLVALGLEDEFLKGTIRFTLGARNTEEEVDFVLEKLNQLIKKI
>NC_022777.1|WP_172645108.1|1574336_1575413_-|tRNA-2-thiouridine(34)-synthase-MnmA
MNILKKKVLVGMSGGVDSSVAAYLLKEQGYEVIGATMQIWQDDKEFIEREGGCCSLSAVADARRVANKIGIPFYVMNFKDAFKKNVIDYFVDEYMEGRTPNPCVACNKFIKFSSFLDKAMNLGIDYVATGHYAIIEKQNNRYIIRKSEDDKKDQTYALYNLTQFQLERTLMPCGRYKKSEIREIAKKIGLRVHNKKDSQEICFIPDNDHGKYIKNRFPSKVRQGNFVDKSGNVLGTHKGIVYYTIGQRKGLDIALGKPMYVVDINPFRNEVVLGNLDDLLNTELIAKDVNYIPFDNLKEPMEVEAKIRYSQIPSKAVITPMEDGRVKVNFNEKQRAITKGQSVVFYKGDLLIGGGIIE
>NC_022777.1|WP_023438394.1|1572442_1573585_-|iron-containing-alcohol-dehydrogenase
MKEFSINTDVYFGEGSLDRLNEIKNKRVLIVCDKFMETSGMVTKVQQKLTDCEVTIYSDIVPDPSVEVIASGIQKLQSCNAQIIIALGGGSSIDGAKAIKEYSKKVTGKTINIEEFYAIPTTSGTGSEVTEYAVITNKQEGLKYAITDKSLLPTVAILDPQLVKSVPKAITADTGMDVITHALEAYVSKNATDFSDALAEKAFTLAFRFLPQAYADGEDIIAREKLHNASCLAGMAFNAAGLGITHSLAHAVGGKLHISHGRSNAIILPYVVEYNANLNKESFNAEYSIAAKKYQRLAKLLKLHAPNVTIGVNNLIKSIVKLQNTLMIPQTLKQQREDINLDETSKEEIINAALRDVCTTSNPRETKKEDFLKILDKVLG
>NC_022777.1|WP_023438393.1|1571529_1572360_-|MerR-family-transcriptional-regulator
MKEELYSIGKVGEICKITKKALRYYDKMDILSPDKVSDESGYRYYSKKTLLSVPMIKYYKQSGFKLEEMKVFLEGETYDFFHKSFRNKIDELKELEKEINLKIRSVKDWDDLIVEAQNVIENNVCDVAIKYIDNKTLTFLDQEFKYDYMDSIINIEFTNYIDSIENAITGPVIIRFPCHEDKMNGKCTKMRIMQETILKCKEELSVEFGGWMAAACYHIGPHETISDTYKKIKEWTKEHGYICFEECYERYVTDYWTTKNTDKFVTEILIKISRER
>NC_022777.1|WP_011099669.1|1569970_1571086_-|membrane-protein
MSENSKTVSLEAIAAKKKLSSDFFKKGISLALFSGLAYGLYTAFLTMGMTKGVWGDWYGDNTAGLSVFVIAYLLAALGNAINDTCSAIWSLLYAVVKGKFGDFLRCINTKPGRIMILAALIGGPIASTAYVIALQMAGSIVVPISALCPAIAAILGKVLYKQELNKRMAFGIVICVCASFLIGSTGFTSDGISRNTLLGLLIAIIAALGWGFEGCVAGYGTAMIDPEIGICIRQVTAGIADLCILLPVLGMMAGGINISVDLTMQAFTSAPAMIWFTLSGLLTFMTFMTWYAGNSMCGAGLGTACNGTYSFFGPLFCLLVLGVYGGMDGWALPTVAWIGAVVMIIGILIISMNPLDLFKRKKMEVDVDETA
>NC_022777.1|WP_023438392.1|1569717_1569984_-|hypothetical-protein
MKPLNYAILKHFTKVPEACVDDVIEALKGEYGHFKALNRKAVTNALMTAEANGLIEEVRFDLDENKQLRVYYHAHKEGADTINKYIPD
>NC_022777.1|WP_023438391.1|1569314_1569611_-|BMC-domain-containing-protein
MRYYGDEALGLVETIGLVPALEAADKMLKAANVELISYENIGSTLVTIMVKGDVAAVKASVEAGAKAAAAIGKLTAHNVMPRPIREVGDIVSVHDIDL
>NC_022777.1|WP_023438390.1|1568984_1569293_-|BMC-domain-containing-protein
MARYRALGLIETFGLVFALEAADAMCKAANVELIGYENVASGYISVLVSGDVGACRSAVDAGVAAVNGMEGGNLYSSIVIPSPHEDLEKIIKRYSITTLIPE
>NC_022777.1|WP_023438389.1|1566305_1568846_-|choline-trimethylamine-lyase
MDIREFSNMLMEATKNMSDEERNGLMNMFQSISKEIRKEEKVTPNVVFNNNGEIPDGMTERLIKLKENYMKQVPSITTHRARAITKIAKENPGVPKSVLRGKCFKYCCETAPLVIQDNELIVGAPNGKPRAGAFSPDIAWRWMEDEIDTIANRPQDPFYISEEDKKIMREELFPYWKGKSVDEYCEDQYREAGVWELSGESFVSDCSYHAVNGGGDSNPGYDVILMKKGMLDIKREAEEKLASLSYERPEDIEKIYFYKSIIDTAEGVMIYAKRMSDYAAELAAKETDPKRKAELQKISEVNARVPAHKPSTFWEAIQAVWTIESLLVVEENQTGMSIGRVDQYMYPFYKSDIESGRMTDFEAFELAGCMLIKMSEMMWITSEGGSKFFAGYQPFVNMCVGGVTREGRDATNELTYLLMDAVRHVKIYQPSLACRIHKGSPQKYLKKIVDVIRAGMGFPACHFDDVHIKMMLAKGVSIEDARDYCLMGCVEPQKAGRLYQWTSTGYTQWPICIELVLNHGVPLWYGKQVCPDMGDLSQFKTYEQFEGAVREQIKYITKWTAVATTISQRVHRELAPKPLMSMMYEGCMEKGRGVEAGGAMYNFGPGVVWSGLATYTDSMAAIKKLVFEEKKYTLEELSEALKADFVGYERLRKDCLEAPKYGNDDDYADYIAADLVNFTEQEHRKYKTLYSVLSHGTLSISNNTPFGQMTGATANGRRAWMPLSDGISPSQGSDFKGPTSIIKSVSKISCEDMNIGMVHNFKLMSGLLDTPEGEQGIIALLRSACALQLGEIQFNYLDNETLIEAQKHPEQYRDLIVRVAGYSAFFVELCKDVQDEIISRTMLTHF
>NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase
MKKRFNVTGTCIPERHYMVDISNKLDSILKLVNNEEYFIINRPRQYGKTTTLYMLERYLNKFKDYLVISISFEGIGDLIFQDEKVFSKEFLQIMSDSLLLNSQALSECLEEQKPHVENFIDLSRVITKFIVKAKRKVVLMIDEVDKSSNNQLFLSFLGLLRNKYLLRNVGKDYTFHNVILAGVHDVKSLKLKIRPDEEHKYNSPWNIASDFDVDMSFSIDEIKTMLDDYVENKEVNLDKEYFAEKIYFYTSGYPFLVSKLCKIVDEKIMVKDELKWEKEYLQIAVKELLKESNTNFDSLIKNIENNKDLQELVRKIILDGYEITYNEDNPLITMGVTYGIFKNSHGKVKIHNRIYEQRIYNYMISLIETKINLGFYTERERYLKPNGDLDIKKVLKKFQEFMKHEYSQKREGFLEEDGRLVFLAFLSPIINGAGFAFKEVQGGEEKRFDIVITYNKKMYILELKIWRGEEYHKKGLKQLVEYLNQYGLEEGYLLIFDFRKATNLIGQVEETHINAEDNIKKIIGVYC
>NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2
MSKNFNYNYAFVFYDVNEKRVNRVFKTCKKYLSHFQKSVFRGELTPANFILLKKDLNKVINEDEDFICIIKLMNNKVYDEEILGNPHSCTGEDLIL
>NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MGSTRYITSVGELKRKDNSLCFRKNNKNVYIPVENTKEIYCMSEVNINSKLLDFLSQNNIIMHFFNYYEGYSGTFYPREHYNSGKLLVKQVETYENRRLEVAKSIVEAIGDNIYELLYHYYKHDKKEVKETLDWIKNHSKTNLKKANDIKQIMQVEGETWQRFYGEFKNILPEEFVMNKRVKRPPDNPINALISFGNTLLYGKTITAIYNTHLDQRISFLHEPSEGRFSLSLDISEAFKPVIVFKTIFDLVNNKRIQVSKHFDKKLNYCLLNDEGRNIFITAFEERMESIFLNEKLKRKISYKTAIKLDCYKLIKFILENKEFKPFSLKERM
>NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4
MKVNGTLINYYFHCKRQCWLHGNRINLEDNSQDVKIGKAIHEVKKEKGKQTEISIDNIKIDKITKDYLTEVKKSDSDIEAAKWQLLLYLKVLKDKGIERKGKLEFIEKNKSKSTIIIELDENNLSELEDVIKNIENLLIQENPPEVINESKCKKCAYFEYCYI
>NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3
MYFKNIEKVNLKDVINKSDKIYAHIGNGKKETLKEHLDLSIKYLCKIYESKSLYNVFLKIENNFLEKFSIEGKEFYRKMLLNTIYMHDLGKINCNFQYRKMGNKEFENEEGLKFNNSNHSMLSSIIYINYFFREMGNLKHKEDREFLIVFLLLNSYIISKHHGSLDSFSEFRKRLVENGEEGKRLYTEQMPIFNKIYKEKIFFNENKLNRIFEKYKLILEDETEKNKGFSIELYIYERFLASLLLSCDYYSTSEFKNQKEVEEFGEIKDIEKFYQSFKNTEVYNWIRKYEKNDYGKTDDFSNIDDINVLRNELFLDAEKTMVSNIDKDIFYLEAPTGSGKSNVSFNLSFKMVERFKEINKIFYVYPFNTLVEQNIKTLEKIFKNNEIMKDIAIINSVVPIKIKSSKDNKIKEIDTNEESDILNEDYERALLDRQFLHYPIVLTTHVSIFNYLFGTSKDNLFPLCQIANSIIVLDEIQSYKNRIWKEIITFLACYSRLLNIKIIIMSATLPNLNKLVDGEIKTVNLIENRKKYFENPIFKNRVMVDFSLLEEKENIKEVLFNNVIKNTKAPNKNILVEFITKESAMDFYEKLKDYNKYLQESEKREIELITGDDNRVDRNRIIDKIKSQKNIILVATQVIEAGVDIDMDIGYKDISMLDSEEQFLGRINRSCKNDAQGIVYFFDLDSASNIYKSDIRKEKNINLNFPKIREILINKNFEEFYDYVIKELNKKAGEHNDSSFQTFFLDKIKTLNFKGIEERMKLIDELYKNSVFLNRNITLENEEELCGEDVWNEYIAILKNNKLDYAEKKIKLSQVTANLNYFIYQVPSNDFIYEDRIGDIYYIGDGEKYFEDGKFDRKKFKSIIVDFI
>NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5
MDALKFSLSGRTAFFKKPDVNSFYYFTYGNIHKVALLGILGAICGYGGYNRQCLNKEQIYPEFYGKLKDINIGIVPKNEKGYIDKKIQVFNNSVGYASKELGGNLIVKEQWLENPKWDIYILMDENVPKDLEDRLLNFKFKYIPYLGKNDHMANITDVEYLENIEKLDNTNKLDSIFIKDKYEIQKLDNDLFDMLNDSYKDVCEYKYEEMLPVSLDETTNKYNLETFIYTNSKLKSLTESKTYQCDSKNIFFF
>NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7
MGMNKRVYGVLGIVSRMSNWNADFTGYPKTTSSGDVFGSDKAFKYPMKKMWENGGEKVLYIKSIKFQENKKKERELIPRTLKERYEYIFDVEDLKKNKDSEEVLKNLFTAIDVKNFGATFAEEGNNISITGAVQIGQGFNKYKETYAEEQQILSPFRDPNQKEKSKDGEEAKSSTLGTKIVSNEAHYFYPFVVNPSSYNQFEEIGVTNGYTEEDYKKFKEASMIAATSFNTNSKIGCENEFALFVETKEDLYLPDLSQYVDFEKVEDKNIITLSCSELLNSFEDEIENIEIYYNPYTTEIKLDEIKKAKKFNIFTKKEV
>NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1
MLKDVISIFKREYEKIGDRYVTESYIPSDGEYIIVDTFENDFKILDKVIIKKDRKTQKIDDSNQYFPFIREADYLSRLLDMNKPIDHKKIIHSNNYLSFFIKKENVNNGKLSDEIIDRYYEILKDPLIKYKNTKAEKLYEEVEEEHGKVNEKLIDEIKNWIKEKIHDFVDKGSKEKEYLKIFFKYDLDKYRKESEKYISPNLYNSNDYNVKIKEEIYGLPNDNMGLNSKKPYLENKTRKSKVPYLISKEEVLIQKKFFDYLMNQVAIGKSNIYINEKGIKGISNKETLGEDFTGYYLRIQKGKEVEIHNFDTIVNYRAKIEPFKLENVLELEKSELNYNVFIYEIGKLKDLIDNVFFYKFLSGNFFTEAKDLNINDATLKRSILLSRDTLFTWFYKGIDNNVWKNLNISSLNLIKGSINKGYLLKAGEQFNLRSSLKNYFEGGISMADVLLEIKNSLREKINKTSKENKNNEDVTLDNDKEYYFAVGQLAYYLISLSKSKNKNHSLVNPIINAKTNERIKDEIRRLYTRYNYRIEFGSKRVERLYSMISSYIPKGKINEDLIIAGFLKNNLIYEKSEEE
>NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6
MKIYELTLKVFLLKDIKSDESLEKISNLIDKSLSKDGKLLDFHERNTYKNYTFNSLYPIEKDKIYNEGKIYSVQIRTVDESLIQYFKKNLTNEYTEYIKALTLECRVIPQRYIEKIYSITPVIIKTEKGYWKGNLSLGEFEERIKNNLIKKYNSFFNTKIDERFTLFRAINLINNKPISCSYKDINILGDKITLIIDENEMAQKLACFSLGSGVGEMNARGYGFVNYKWL
>NC_022777.1|WP_023438408.1|1589704_1589851_-|hypothetical-protein
MKKKLKFSISATYEDLKEKERIEIDDIIYIIELVSVITLILKIFQFKN

Crispr_ID: NC_022777_5

• CRISPR_ID: NC_022777_5
• CRISPR_location: 1580469-1580758
• CRISPR_type: TypeI-B
• Repeat_type: III-B
• Spacer_info: 4 spacers
• Cas_protein_info: cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6

Consensus repeat of NC_022777_5

Consensus_repeat	Method
ATTTAAATACAACTCTTGTTATTGTTCAAC	CRISPRCasFinder
ATTTAAATACAACTCTTGTTATTGTTCAAC	CRT
TTTAAATACAACTCTTGTTATTGTTCAAC	PILER-CR

spacers of NC_022777_5

>5.1|1580499|36|NC_022777|CRISPRCasFinder,CRT
AACTGTATATATTCTTCGATTGCTACAGAATTTTGA
>5.2|1580565|34|NC_022777|CRISPRCasFinder,CRT
ATATTTCTTTTTTACTCCAATAAGCTCCAATGAG
>5.3|1580629|36|NC_022777|CRISPRCasFinder,CRT
TATTAATTTTATATTAAACAAAAATCATAAATTCAA
>5.4|1580695|34|NC_022777|CRISPRCasFinder,CRT
TTACGGCTGGATCCCTACTATAGTTTTCTAGCTG
>5.5|1580499|37|NC_022777|PILER-CR
AACTGTATATATTCTTCGATTGCTACAGAATTTTGAA
>5.6|1580565|35|NC_022777|PILER-CR
ATATTTCTTTTTTACTCCAATAAGCTCCAATGAGA
>5.7|1580629|37|NC_022777|PILER-CR
TATTAATTTTATATTAAACAAAAATCATAAATTCAAA
>5.8|1580695|35|NC_022777|PILER-CR
TTACGGCTGGATCCCTACTATAGTTTTCTAGCTGA

CRISPR arrays and Neighbor proteins around NC_022777_5

CRISPR arrays

The CRISPR arrays of NC_022777_5

>merge|NC_022777|5|1580469-1580758|CRISPRCasFinder,CRT,PILER-CR
TTTTAAATACAACTCTTGTTATTGTTCAACAACTGTATATATTCTTCGATTGCTACAGAATTTTGAATTTAAATACAACTCTTGTTATTGTTCAACATATTTCTTTTTTACTCCAATAAGCTCCAATGAGATTTAAATACAACTCTTGTTATTGTTCAACTATTAATTTTATATTAAACAAAAATCATAAATTCAAATTTAAATACAACTCTTGTTATTGTTCAACTTACGGCTGGATCCCTACTATAGTTTTCTAGCTGATTTAAATACAACTCTTGTTATTGTTCAAC

>NC_022777|5|5|1580469-1580758|CRISPRCasFinder
TTTTAAATACAACTCTTGTTATTGTTCAAC	AACTGTATATATTCTTCGATTGCTACAGAATTTTGA
ATTTAAATACAACTCTTGTTATTGTTCAAC	ATATTTCTTTTTTACTCCAATAAGCTCCAATGAG
ATTTAAATACAACTCTTGTTATTGTTCAAC	TATTAATTTTATATTAAACAAAAATCATAAATTCAA
ATTTAAATACAACTCTTGTTATTGTTCAAC	TTACGGCTGGATCCCTACTATAGTTTTCTAGCTG
ATTTAAATACAACTCTTGTTATTGTTCAAC

>NC_022777|5|4|1580469-1580758|CRT
TTTTAAATACAACTCTTGTTATTGTTCAAC	AACTGTATATATTCTTCGATTGCTACAGAATTTTGA
ATTTAAATACAACTCTTGTTATTGTTCAAC	ATATTTCTTTTTTACTCCAATAAGCTCCAATGAG
ATTTAAATACAACTCTTGTTATTGTTCAAC	TATTAATTTTATATTAAACAAAAATCATAAATTCAA
ATTTAAATACAACTCTTGTTATTGTTCAAC	TTACGGCTGGATCCCTACTATAGTTTTCTAGCTG
ATTTAAATACAACTCTTGTTATTGTTCAAC

>NC_022777|5|5|1580470-1580758|PILER-CR
TTTAAATACAACTCTTGTTATTGTTCAAC	AACTGTATATATTCTTCGATTGCTACAGAATTTTGAA
TTTAAATACAACTCTTGTTATTGTTCAAC	ATATTTCTTTTTTACTCCAATAAGCTCCAATGAGA
TTTAAATACAACTCTTGTTATTGTTCAAC	TATTAATTTTATATTAAACAAAAATCATAAATTCAAA
TTTAAATACAACTCTTGTTATTGTTCAAC	TTACGGCTGGATCCCTACTATAGTTTTCTAGCTGA
TTTAAATACAACTCTTGTTATTGTTCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_022777.1|WP_023438391.1|1569314_1569611_-|BMC-domain-containing-protein	unknown	unknown	gnl|CDD|132885
NC_022777.1|WP_011099669.1|1569970_1571086_-|membrane-protein	unknown	unknown	gnl|CDD|273359
NC_022777.1|WP_023438390.1|1568984_1569293_-|BMC-domain-containing-protein	unknown	unknown	gnl|CDD|132885
NC_022777.1|WP_023438396.1|1575446_1576583_-|cysteine-desulfurase	unknown	unknown	gnl|CDD|224029
NC_022777.1|WP_023438394.1|1572442_1573585_-|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl|CDD|341459
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl|CDD|131641
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl|CDD|188234
NC_022777.1|WP_172645108.1|1574336_1575413_-|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl|CDD|234664
NC_022777.1|WP_023438413.1|1594021_1595170_-|polysaccharide-deacetylase	unknown	unknown	gnl|CDD|213022
NC_022777.1|WP_023438393.1|1571529_1572360_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133382
NC_022777.1|WP_023438397.1|1576958_1577771_+|hypothetical-protein	unknown	unknown	gnl|CDD|234750
NC_022777.1|WP_023438408.1|1589704_1589851_-|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|313108
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl|CDD|187770
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_022777.1|WP_023438392.1|1569717_1569984_-|hypothetical-protein	unknown	unknown	unknown

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	1.6e-91	300.8	4.1
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	cas8b1	mkCas0106_cas8b1_CAS-I-B	9.1e-190	627.1	73.3
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	1.9e-28	94.5	1.0
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	3.3e-47	155.9	10.5
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	2.1e-23	78.4	8.7
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	4.2e-132	434.9	15.7
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.8e-27	90.2	0.2
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	2.3e-50	165.6	7.4

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022777.1|WP_023438391.1|1569314_1569611_-|BMC-domain-containing-protein	gnl|CDD|132885	cd07045, BMC_CcmK_like, Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain. Bacterial micro-compartments are primitive protein-based organelles that sequester specific metabolic pathways in bacterial cells. The prototypical bacterial microcompartment is the carboxysome shell, a bacterial polyhedral organelle which increase the efficiency of CO2 fixation by encapsulating RuBisCO and carbonic anhydrase. They can be divided into two types: alpha-type carboxysomes (alpha-cyanobacteria and proteobacteria) and beta-type carboxysomes (beta-cyanobacteria). Potential functional differences between the two types are not yet fully understood. In addition to these proteins there are several homologous shell proteins including those found in pdu organelles involved in coenzyme B12-dependent degradation of 1,2-propanediol and eut organelles involved in the cobalamin-dependent degradation of ethanolamine. Structure evidence shows that several carboxysome shell proteins and their homologs (Csos1A, CcmK1,2,4, and PduU) exist as hexamers which might further assemble into extended, tightly packed layers hypothesized to represent the flat facets of the polyhedral organelles outer shell. Although it has been suggested that other homologous proteins in this family might also form hexamers and play similar functional roles in the construction of their corresponding organelle outer shells at present no experimental evidence directly supports this view.	8.2144e-32
NC_022777.1|WP_011099669.1|1569970_1571086_-|membrane-protein	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	0.00632714
NC_022777.1|WP_023438390.1|1568984_1569293_-|BMC-domain-containing-protein	gnl|CDD|132885	cd07045, BMC_CcmK_like, Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain. Bacterial micro-compartments are primitive protein-based organelles that sequester specific metabolic pathways in bacterial cells. The prototypical bacterial microcompartment is the carboxysome shell, a bacterial polyhedral organelle which increase the efficiency of CO2 fixation by encapsulating RuBisCO and carbonic anhydrase. They can be divided into two types: alpha-type carboxysomes (alpha-cyanobacteria and proteobacteria) and beta-type carboxysomes (beta-cyanobacteria). Potential functional differences between the two types are not yet fully understood. In addition to these proteins there are several homologous shell proteins including those found in pdu organelles involved in coenzyme B12-dependent degradation of 1,2-propanediol and eut organelles involved in the cobalamin-dependent degradation of ethanolamine. Structure evidence shows that several carboxysome shell proteins and their homologs (Csos1A, CcmK1,2,4, and PduU) exist as hexamers which might further assemble into extended, tightly packed layers hypothesized to represent the flat facets of the polyhedral organelles outer shell. Although it has been suggested that other homologous proteins in this family might also form hexamers and play similar functional roles in the construction of their corresponding organelle outer shells at present no experimental evidence directly supports this view.	4.67179e-33
NC_022777.1|WP_023438396.1|1575446_1576583_-|cysteine-desulfurase	gnl|CDD|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	0
NC_022777.1|WP_023438394.1|1572442_1573585_-|iron-containing-alcohol-dehydrogenase	gnl|CDD|341459	cd08180, PDD, 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism. 1,3-propanediol dehydrogenase (PPD) plays a role in glycerol metabolism of some bacteria in anaerobic conditions. In this degradation pathway, glycerol is converted in a two-step process to 1,3-propanediol (1,3-PD) which is then excreted into the extracellular medium. The first reaction involves the transformation of glycerol into 3-hydroxypropionaldehyde (3-HPA) by a coenzyme B-12-dependent dehydratase. The second reaction involves the dismutation of the 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol by the NADH-linked 1,3-propanediol dehydrogenase (PPD). The enzyme requires iron ion for its function. Because many genes in this pathway are present in the propanediol utilization (pdu) operon, they are also named pdu genes. PPD is a member of the iron-containing alcohol dehydrogenase superfamily. The PPD structure has a dehydroquinate synthase-like fold.	2.12677e-180
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.45511e-22
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.17517e-60
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	gnl|CDD|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.0638e-96
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	gnl|CDD|188234	TIGR02591, cas_Csh1, CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI. This domain is found in the C-terminal 2/3 of a family of CRISPR associated proteins of the Hmari subtype. Except for the two sequences from halophilic archaea this domain contains a pair of CXXC motifs.	1.46816e-84
NC_022777.1|WP_172645108.1|1574336_1575413_-|tRNA-2-thiouridine(34)-synthase-MnmA	gnl|CDD|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_022777.1|WP_023438413.1|1594021_1595170_-|polysaccharide-deacetylase	gnl|CDD|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	0.000167005
NC_022777.1|WP_023438393.1|1571529_1572360_-|MerR-family-transcriptional-regulator	gnl|CDD|133382	cd01107, HTH_BmrR, Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	4.10036e-38
NC_022777.1|WP_023438397.1|1576958_1577771_+|hypothetical-protein	gnl|CDD|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	0.000256269
NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase	gnl|CDD|313108	pfam09820, AAA-ATPase_like, Predicted AAA-ATPase. This family contains many hypothetical bacterial proteins. This family was previously the N-terminal part of the Pfam DUF1703 (pfam08011) family before it was split into two. This region is predicted to be an AAA-ATPase domain.	5.17626e-07
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.04177e-29
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.13188e-163
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.34287e-28
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.41443e-49

Protein sequences

>NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase
MKKRFNVTGTCIPERHYMVDISNKLDSILKLVNNEEYFIINRPRQYGKTTTLYMLERYLNKFKDYLVISISFEGIGDLIFQDEKVFSKEFLQIMSDSLLLNSQALSECLEEQKPHVENFIDLSRVITKFIVKAKRKVVLMIDEVDKSSNNQLFLSFLGLLRNKYLLRNVGKDYTFHNVILAGVHDVKSLKLKIRPDEEHKYNSPWNIASDFDVDMSFSIDEIKTMLDDYVENKEVNLDKEYFAEKIYFYTSGYPFLVSKLCKIVDEKIMVKDELKWEKEYLQIAVKELLKESNTNFDSLIKNIENNKDLQELVRKIILDGYEITYNEDNPLITMGVTYGIFKNSHGKVKIHNRIYEQRIYNYMISLIETKINLGFYTERERYLKPNGDLDIKKVLKKFQEFMKHEYSQKREGFLEEDGRLVFLAFLSPIINGAGFAFKEVQGGEEKRFDIVITYNKKMYILELKIWRGEEYHKKGLKQLVEYLNQYGLEEGYLLIFDFRKATNLIGQVEETHINAEDNIKKIIGVYC
>NC_022777.1|WP_023438397.1|1576958_1577771_+|hypothetical-protein
MFKSLSKKVIISVVILIVVLLGVLGMKNYNKSKDYKNLVTTANEYMNEKDYDKAMDKFKESLDYKKDQKAEEKLEECKNELINLSKEALKNKEYEKADNYLNVLLKHDGKNEEAIKMKNTIKDEIQKSKEEEEIKKAIEKEKREQELKKQMDKEEQAKKKTGITEQNKKKEVKENNKITKEKAESLVQPLKNKNEEIRYLGTRQVPEIPAKSTPYKKFPKEIENKKVYIFDIAVVYNSDSKATIGRYYVDFSGNIYKDTYPSNLECVKVK
>NC_022777.1|WP_023438396.1|1575446_1576583_-|cysteine-desulfurase
MKKNIYMDYAATTYIKKEVIEAMMPYLTEYYANPSSVYNMSNNLKIVIDEAKEEIADFIGATPEEVFFTSGGTEGNNWAIKGIAYANEEKGKHIITSSIEHPAVLNSCKYLKEKGFEITFLPVDSYGKVDLEKLEKSIRNDTILVSIMAANNEIGTIQHIKSIGEICKRHKVLFHTDAVQALGQISINAEEMDIDLMTITAHKIYGPKGIGALYIKKGTKIENILHGGSQERGKRPGTENTAAIVGFKKAVSLLKENGLEESKRIEKLRDKFIKGLLQIENTKINGAMGKERLKGNVNVSFKNIDGELLLMLLDREGIYASAGSACSAGSIDASHVLVALGLEDEFLKGTIRFTLGARNTEEEVDFVLEKLNQLIKKI
>NC_022777.1|WP_172645108.1|1574336_1575413_-|tRNA-2-thiouridine(34)-synthase-MnmA
MNILKKKVLVGMSGGVDSSVAAYLLKEQGYEVIGATMQIWQDDKEFIEREGGCCSLSAVADARRVANKIGIPFYVMNFKDAFKKNVIDYFVDEYMEGRTPNPCVACNKFIKFSSFLDKAMNLGIDYVATGHYAIIEKQNNRYIIRKSEDDKKDQTYALYNLTQFQLERTLMPCGRYKKSEIREIAKKIGLRVHNKKDSQEICFIPDNDHGKYIKNRFPSKVRQGNFVDKSGNVLGTHKGIVYYTIGQRKGLDIALGKPMYVVDINPFRNEVVLGNLDDLLNTELIAKDVNYIPFDNLKEPMEVEAKIRYSQIPSKAVITPMEDGRVKVNFNEKQRAITKGQSVVFYKGDLLIGGGIIE
>NC_022777.1|WP_023438394.1|1572442_1573585_-|iron-containing-alcohol-dehydrogenase
MKEFSINTDVYFGEGSLDRLNEIKNKRVLIVCDKFMETSGMVTKVQQKLTDCEVTIYSDIVPDPSVEVIASGIQKLQSCNAQIIIALGGGSSIDGAKAIKEYSKKVTGKTINIEEFYAIPTTSGTGSEVTEYAVITNKQEGLKYAITDKSLLPTVAILDPQLVKSVPKAITADTGMDVITHALEAYVSKNATDFSDALAEKAFTLAFRFLPQAYADGEDIIAREKLHNASCLAGMAFNAAGLGITHSLAHAVGGKLHISHGRSNAIILPYVVEYNANLNKESFNAEYSIAAKKYQRLAKLLKLHAPNVTIGVNNLIKSIVKLQNTLMIPQTLKQQREDINLDETSKEEIINAALRDVCTTSNPRETKKEDFLKILDKVLG
>NC_022777.1|WP_023438393.1|1571529_1572360_-|MerR-family-transcriptional-regulator
MKEELYSIGKVGEICKITKKALRYYDKMDILSPDKVSDESGYRYYSKKTLLSVPMIKYYKQSGFKLEEMKVFLEGETYDFFHKSFRNKIDELKELEKEINLKIRSVKDWDDLIVEAQNVIENNVCDVAIKYIDNKTLTFLDQEFKYDYMDSIINIEFTNYIDSIENAITGPVIIRFPCHEDKMNGKCTKMRIMQETILKCKEELSVEFGGWMAAACYHIGPHETISDTYKKIKEWTKEHGYICFEECYERYVTDYWTTKNTDKFVTEILIKISRER
>NC_022777.1|WP_011099669.1|1569970_1571086_-|membrane-protein
MSENSKTVSLEAIAAKKKLSSDFFKKGISLALFSGLAYGLYTAFLTMGMTKGVWGDWYGDNTAGLSVFVIAYLLAALGNAINDTCSAIWSLLYAVVKGKFGDFLRCINTKPGRIMILAALIGGPIASTAYVIALQMAGSIVVPISALCPAIAAILGKVLYKQELNKRMAFGIVICVCASFLIGSTGFTSDGISRNTLLGLLIAIIAALGWGFEGCVAGYGTAMIDPEIGICIRQVTAGIADLCILLPVLGMMAGGINISVDLTMQAFTSAPAMIWFTLSGLLTFMTFMTWYAGNSMCGAGLGTACNGTYSFFGPLFCLLVLGVYGGMDGWALPTVAWIGAVVMIIGILIISMNPLDLFKRKKMEVDVDETA
>NC_022777.1|WP_023438392.1|1569717_1569984_-|hypothetical-protein
MKPLNYAILKHFTKVPEACVDDVIEALKGEYGHFKALNRKAVTNALMTAEANGLIEEVRFDLDENKQLRVYYHAHKEGADTINKYIPD
>NC_022777.1|WP_023438391.1|1569314_1569611_-|BMC-domain-containing-protein
MRYYGDEALGLVETIGLVPALEAADKMLKAANVELISYENIGSTLVTIMVKGDVAAVKASVEAGAKAAAAIGKLTAHNVMPRPIREVGDIVSVHDIDL
>NC_022777.1|WP_023438390.1|1568984_1569293_-|BMC-domain-containing-protein
MARYRALGLIETFGLVFALEAADAMCKAANVELIGYENVASGYISVLVSGDVGACRSAVDAGVAAVNGMEGGNLYSSIVIPSPHEDLEKIIKRYSITTLIPE
>NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2
MSKNFNYNYAFVFYDVNEKRVNRVFKTCKKYLSHFQKSVFRGELTPANFILLKKDLNKVINEDEDFICIIKLMNNKVYDEEILGNPHSCTGEDLIL
>NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MGSTRYITSVGELKRKDNSLCFRKNNKNVYIPVENTKEIYCMSEVNINSKLLDFLSQNNIIMHFFNYYEGYSGTFYPREHYNSGKLLVKQVETYENRRLEVAKSIVEAIGDNIYELLYHYYKHDKKEVKETLDWIKNHSKTNLKKANDIKQIMQVEGETWQRFYGEFKNILPEEFVMNKRVKRPPDNPINALISFGNTLLYGKTITAIYNTHLDQRISFLHEPSEGRFSLSLDISEAFKPVIVFKTIFDLVNNKRIQVSKHFDKKLNYCLLNDEGRNIFITAFEERMESIFLNEKLKRKISYKTAIKLDCYKLIKFILENKEFKPFSLKERM
>NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4
MKVNGTLINYYFHCKRQCWLHGNRINLEDNSQDVKIGKAIHEVKKEKGKQTEISIDNIKIDKITKDYLTEVKKSDSDIEAAKWQLLLYLKVLKDKGIERKGKLEFIEKNKSKSTIIIELDENNLSELEDVIKNIENLLIQENPPEVINESKCKKCAYFEYCYI
>NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3
MYFKNIEKVNLKDVINKSDKIYAHIGNGKKETLKEHLDLSIKYLCKIYESKSLYNVFLKIENNFLEKFSIEGKEFYRKMLLNTIYMHDLGKINCNFQYRKMGNKEFENEEGLKFNNSNHSMLSSIIYINYFFREMGNLKHKEDREFLIVFLLLNSYIISKHHGSLDSFSEFRKRLVENGEEGKRLYTEQMPIFNKIYKEKIFFNENKLNRIFEKYKLILEDETEKNKGFSIELYIYERFLASLLLSCDYYSTSEFKNQKEVEEFGEIKDIEKFYQSFKNTEVYNWIRKYEKNDYGKTDDFSNIDDINVLRNELFLDAEKTMVSNIDKDIFYLEAPTGSGKSNVSFNLSFKMVERFKEINKIFYVYPFNTLVEQNIKTLEKIFKNNEIMKDIAIINSVVPIKIKSSKDNKIKEIDTNEESDILNEDYERALLDRQFLHYPIVLTTHVSIFNYLFGTSKDNLFPLCQIANSIIVLDEIQSYKNRIWKEIITFLACYSRLLNIKIIIMSATLPNLNKLVDGEIKTVNLIENRKKYFENPIFKNRVMVDFSLLEEKENIKEVLFNNVIKNTKAPNKNILVEFITKESAMDFYEKLKDYNKYLQESEKREIELITGDDNRVDRNRIIDKIKSQKNIILVATQVIEAGVDIDMDIGYKDISMLDSEEQFLGRINRSCKNDAQGIVYFFDLDSASNIYKSDIRKEKNINLNFPKIREILINKNFEEFYDYVIKELNKKAGEHNDSSFQTFFLDKIKTLNFKGIEERMKLIDELYKNSVFLNRNITLENEEELCGEDVWNEYIAILKNNKLDYAEKKIKLSQVTANLNYFIYQVPSNDFIYEDRIGDIYYIGDGEKYFEDGKFDRKKFKSIIVDFI
>NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5
MDALKFSLSGRTAFFKKPDVNSFYYFTYGNIHKVALLGILGAICGYGGYNRQCLNKEQIYPEFYGKLKDINIGIVPKNEKGYIDKKIQVFNNSVGYASKELGGNLIVKEQWLENPKWDIYILMDENVPKDLEDRLLNFKFKYIPYLGKNDHMANITDVEYLENIEKLDNTNKLDSIFIKDKYEIQKLDNDLFDMLNDSYKDVCEYKYEEMLPVSLDETTNKYNLETFIYTNSKLKSLTESKTYQCDSKNIFFF
>NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7
MGMNKRVYGVLGIVSRMSNWNADFTGYPKTTSSGDVFGSDKAFKYPMKKMWENGGEKVLYIKSIKFQENKKKERELIPRTLKERYEYIFDVEDLKKNKDSEEVLKNLFTAIDVKNFGATFAEEGNNISITGAVQIGQGFNKYKETYAEEQQILSPFRDPNQKEKSKDGEEAKSSTLGTKIVSNEAHYFYPFVVNPSSYNQFEEIGVTNGYTEEDYKKFKEASMIAATSFNTNSKIGCENEFALFVETKEDLYLPDLSQYVDFEKVEDKNIITLSCSELLNSFEDEIENIEIYYNPYTTEIKLDEIKKAKKFNIFTKKEV
>NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1
MLKDVISIFKREYEKIGDRYVTESYIPSDGEYIIVDTFENDFKILDKVIIKKDRKTQKIDDSNQYFPFIREADYLSRLLDMNKPIDHKKIIHSNNYLSFFIKKENVNNGKLSDEIIDRYYEILKDPLIKYKNTKAEKLYEEVEEEHGKVNEKLIDEIKNWIKEKIHDFVDKGSKEKEYLKIFFKYDLDKYRKESEKYISPNLYNSNDYNVKIKEEIYGLPNDNMGLNSKKPYLENKTRKSKVPYLISKEEVLIQKKFFDYLMNQVAIGKSNIYINEKGIKGISNKETLGEDFTGYYLRIQKGKEVEIHNFDTIVNYRAKIEPFKLENVLELEKSELNYNVFIYEIGKLKDLIDNVFFYKFLSGNFFTEAKDLNINDATLKRSILLSRDTLFTWFYKGIDNNVWKNLNISSLNLIKGSINKGYLLKAGEQFNLRSSLKNYFEGGISMADVLLEIKNSLREKINKTSKENKNNEDVTLDNDKEYYFAVGQLAYYLISLSKSKNKNHSLVNPIINAKTNERIKDEIRRLYTRYNYRIEFGSKRVERLYSMISSYIPKGKINEDLIIAGFLKNNLIYEKSEEE
>NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6
MKIYELTLKVFLLKDIKSDESLEKISNLIDKSLSKDGKLLDFHERNTYKNYTFNSLYPIEKDKIYNEGKIYSVQIRTVDESLIQYFKKNLTNEYTEYIKALTLECRVIPQRYIEKIYSITPVIIKTEKGYWKGNLSLGEFEERIKNNLIKKYNSFFNTKIDERFTLFRAINLINNKPISCSYKDINILGDKITLIIDENEMAQKLACFSLGSGVGEMNARGYGFVNYKWL
>NC_022777.1|WP_023438408.1|1589704_1589851_-|hypothetical-protein
MKKKLKFSISATYEDLKEKERIEIDDIIYIIELVSVITLILKIFQFKN
>NC_022777.1|WP_023438413.1|1594021_1595170_-|polysaccharide-deacetylase
MRRKNKFGVILFLMIIITALSIILSDSRGSRQFIKSQKSENMASKNEKNKKKIKSEKYNGEMEFYNGEIEHLFFHPLILDKKAAFTGPKWHTDNMDNWLVTVEESKKVINSLYSKGYILIDPNSLYEEYESDGKKLFRKKPLKVPKGKKPLILSIDDLSYNEGMRKATALKLILDENGNLATYRKDQNGKEIIGYDEIVMILDRFVKEHPDFSLNGAKGVIALTGYEGVFGYRTNLDSKNREEEAKKAKVIANKLKENGWKFASHSYGHLDNAKIPFQTLKRDADKWEQLVKPIIGHTSIYVYPHGTAIKTNSEKFKYLQSKGFKIFYSVDSYLGERISENDLVVEGGRMPIDGLSMRNRREAFLKFFDAKEVLDLESRPKR

Crispr_ID: NC_022777_6

• CRISPR_ID: NC_022777_6
• CRISPR_location: 1590062-1590420
• CRISPR_type: TypeI-B
• Repeat_type: III-B
• Spacer_info: 5 spacers
• Cas_protein_info: cas6,cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2

Consensus repeat of NC_022777_6

Consensus_repeat	Method
ATTTAAATACATCCTATGTTAAGGTTCAAC	CRISPRCasFinder
ATTTAAATACATCCTATGTTAAGGTTCAAC	CRT
ATTTAAATACATCCTATGTTAAGGTTCAAC	PILER-CR

spacers of NC_022777_6

>6.1|1590092|37|NC_022777|CRISPRCasFinder,CRT
GATATCTCCTATTATAACTAGTATTGCCAATAATCCT
>6.2|1590159|36|NC_022777|CRISPRCasFinder,CRT,PILER-CR
TAGTAGCTATATCTATACTTATTGCTATAGCTATAA
>6.3|1590225|37|NC_022777|CRISPRCasFinder,CRT,PILER-CR
GCAAAGAACAAGTATTAGAGTACGTAAATAGGTTTGG
>6.4|1590292|35|NC_022777|CRISPRCasFinder,CRT,PILER-CR
AAAAGCCAATCAAAATCTATTTTATATTTAGATTT
>6.5|1590357|34|NC_022777|CRISPRCasFinder,CRT,PILER-CR
GGCAGAGAAATCGCAAGAATAACAGCTAAACCAA

CRISPR arrays and Neighbor proteins around NC_022777_6

CRISPR arrays

The CRISPR arrays of NC_022777_6

>merge|NC_022777|6|1590062-1590420|CRISPRCasFinder,CRT,PILER-CR
TTTTAAATACACATAATGTTAAGGTTTAACGATATCTCCTATTATAACTAGTATTGCCAATAATCCTATTTAAATACATCCTATGTTAAGGTTCAACTAGTAGCTATATCTATACTTATTGCTATAGCTATAAATTTAAATACATCCTATGTTAAGGTTCAACGCAAAGAACAAGTATTAGAGTACGTAAATAGGTTTGGATTTAAATACATCCTATGTTAAGGTTCAACAAAAGCCAATCAAAATCTATTTTATATTTAGATTTATTTAAATACATCCTATGTTAAGGTTCAACGGCAGAGAAATCGCAAGAATAACAGCTAAACCAAATTTAAATACATCCTATGTTAAGGTTCAAC

>NC_022777|6|6|1590062-1590420|CRISPRCasFinder
TTTTAAATACACATAATGTTAAGGTTTAAC	GATATCTCCTATTATAACTAGTATTGCCAATAATCCT
ATTTAAATACATCCTATGTTAAGGTTCAAC	TAGTAGCTATATCTATACTTATTGCTATAGCTATAA
ATTTAAATACATCCTATGTTAAGGTTCAAC	GCAAAGAACAAGTATTAGAGTACGTAAATAGGTTTGG
ATTTAAATACATCCTATGTTAAGGTTCAAC	AAAAGCCAATCAAAATCTATTTTATATTTAGATTT
ATTTAAATACATCCTATGTTAAGGTTCAAC	GGCAGAGAAATCGCAAGAATAACAGCTAAACCAA
ATTTAAATACATCCTATGTTAAGGTTCAAC

>NC_022777|6|5|1590062-1590420|CRT
TTTTAAATACACATAATGTTAAGGTTTAAC	GATATCTCCTATTATAACTAGTATTGCCAATAATCCT
ATTTAAATACATCCTATGTTAAGGTTCAAC	TAGTAGCTATATCTATACTTATTGCTATAGCTATAA
ATTTAAATACATCCTATGTTAAGGTTCAAC	GCAAAGAACAAGTATTAGAGTACGTAAATAGGTTTGG
ATTTAAATACATCCTATGTTAAGGTTCAAC	AAAAGCCAATCAAAATCTATTTTATATTTAGATTT
ATTTAAATACATCCTATGTTAAGGTTCAAC	GGCAGAGAAATCGCAAGAATAACAGCTAAACCAA
ATTTAAATACATCCTATGTTAAGGTTCAAC

>NC_022777|6|6|1590129-1590420|PILER-CR
ATTTAAATACATCCTATGTTAAGGTTCAAC	TAGTAGCTATATCTATACTTATTGCTATAGCTATAA
ATTTAAATACATCCTATGTTAAGGTTCAAC	GCAAAGAACAAGTATTAGAGTACGTAAATAGGTTTGG
ATTTAAATACATCCTATGTTAAGGTTCAAC	AAAAGCCAATCAAAATCTATTTTATATTTAGATTT
ATTTAAATACATCCTATGTTAAGGTTCAAC	GGCAGAGAAATCGCAAGAATAACAGCTAAACCAA
ATTTAAATACATCCTATGTTAAGGTTCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022777.1|WP_155276578.1|1597726_1597885_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438420.1|1601929_1602112_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438414.1|1596183_1596507_-|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl|CDD|188234
NC_022777.1|WP_023438418.1|1598095_1599184_-|amidase-domain-containing-protein	unknown	unknown	gnl|CDD|378910
NC_022777.1|WP_011099693.1|1599906_1600500_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|313108
NC_022777.1|WP_023438421.1|1602272_1604000_+|histidine-decarboxylase	unknown	unknown	gnl|CDD|235068
NC_022777.1|WP_023438408.1|1589704_1589851_-|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438413.1|1594021_1595170_-|polysaccharide-deacetylase	unknown	unknown	gnl|CDD|213022
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl|CDD|131641
NC_022777.1|WP_023438422.1|1604123_1604705_-|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl|CDD|239264
NC_022777.1|WP_011099692.1|1599348_1599906_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl|CDD|187770
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_022777.1|WP_080744613.1|1600510_1601818_-|S41-family-peptidase	unknown	unknown	gnl|CDD|367567
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	3.3e-47	155.9	10.5
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	cas8b1	mkCas0106_cas8b1_CAS-I-B	9.1e-190	627.1	73.3
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	1.9e-28	94.5	1.0
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	1.6e-91	300.8	4.1
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.8e-27	90.2	0.2
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	2.3e-50	165.6	7.4
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	2.1e-23	78.4	8.7
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	4.2e-132	434.9	15.7

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	gnl|CDD|188234	TIGR02591, cas_Csh1, CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI. This domain is found in the C-terminal 2/3 of a family of CRISPR associated proteins of the Hmari subtype. Except for the two sequences from halophilic archaea this domain contains a pair of CXXC motifs.	1.46816e-84
NC_022777.1|WP_023438418.1|1598095_1599184_-|amidase-domain-containing-protein	gnl|CDD|378910	pfam12671, Amidase_6, Putative amidase domain.	1.21538e-30
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.45511e-22
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.17517e-60
NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase	gnl|CDD|313108	pfam09820, AAA-ATPase_like, Predicted AAA-ATPase. This family contains many hypothetical bacterial proteins. This family was previously the N-terminal part of the Pfam DUF1703 (pfam08011) family before it was split into two. This region is predicted to be an AAA-ATPase domain.	5.17626e-07
NC_022777.1|WP_023438421.1|1602272_1604000_+|histidine-decarboxylase	gnl|CDD|235068	PRK02769, PRK02769, histidine decarboxylase; Provisional.	4.54756e-68
NC_022777.1|WP_023438413.1|1594021_1595170_-|polysaccharide-deacetylase	gnl|CDD|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	0.000167005
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	gnl|CDD|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.0638e-96
NC_022777.1|WP_023438422.1|1604123_1604705_-|TlpA-family-protein-disulfide-reductase	gnl|CDD|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	3.70776e-27
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.41443e-49
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.04177e-29
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.13188e-163
NC_022777.1|WP_080744613.1|1600510_1601818_-|S41-family-peptidase	gnl|CDD|367567	pfam03572, Peptidase_S41, Peptidase family S41.	9.86301e-25
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.34287e-28

Protein sequences

>NC_022777.1|WP_023438408.1|1589704_1589851_-|hypothetical-protein
MKKKLKFSISATYEDLKEKERIEIDDIIYIIELVSVITLILKIFQFKN
>NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6
MKIYELTLKVFLLKDIKSDESLEKISNLIDKSLSKDGKLLDFHERNTYKNYTFNSLYPIEKDKIYNEGKIYSVQIRTVDESLIQYFKKNLTNEYTEYIKALTLECRVIPQRYIEKIYSITPVIIKTEKGYWKGNLSLGEFEERIKNNLIKKYNSFFNTKIDERFTLFRAINLINNKPISCSYKDINILGDKITLIIDENEMAQKLACFSLGSGVGEMNARGYGFVNYKWL
>NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1
MLKDVISIFKREYEKIGDRYVTESYIPSDGEYIIVDTFENDFKILDKVIIKKDRKTQKIDDSNQYFPFIREADYLSRLLDMNKPIDHKKIIHSNNYLSFFIKKENVNNGKLSDEIIDRYYEILKDPLIKYKNTKAEKLYEEVEEEHGKVNEKLIDEIKNWIKEKIHDFVDKGSKEKEYLKIFFKYDLDKYRKESEKYISPNLYNSNDYNVKIKEEIYGLPNDNMGLNSKKPYLENKTRKSKVPYLISKEEVLIQKKFFDYLMNQVAIGKSNIYINEKGIKGISNKETLGEDFTGYYLRIQKGKEVEIHNFDTIVNYRAKIEPFKLENVLELEKSELNYNVFIYEIGKLKDLIDNVFFYKFLSGNFFTEAKDLNINDATLKRSILLSRDTLFTWFYKGIDNNVWKNLNISSLNLIKGSINKGYLLKAGEQFNLRSSLKNYFEGGISMADVLLEIKNSLREKINKTSKENKNNEDVTLDNDKEYYFAVGQLAYYLISLSKSKNKNHSLVNPIINAKTNERIKDEIRRLYTRYNYRIEFGSKRVERLYSMISSYIPKGKINEDLIIAGFLKNNLIYEKSEEE
>NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7
MGMNKRVYGVLGIVSRMSNWNADFTGYPKTTSSGDVFGSDKAFKYPMKKMWENGGEKVLYIKSIKFQENKKKERELIPRTLKERYEYIFDVEDLKKNKDSEEVLKNLFTAIDVKNFGATFAEEGNNISITGAVQIGQGFNKYKETYAEEQQILSPFRDPNQKEKSKDGEEAKSSTLGTKIVSNEAHYFYPFVVNPSSYNQFEEIGVTNGYTEEDYKKFKEASMIAATSFNTNSKIGCENEFALFVETKEDLYLPDLSQYVDFEKVEDKNIITLSCSELLNSFEDEIENIEIYYNPYTTEIKLDEIKKAKKFNIFTKKEV
>NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5
MDALKFSLSGRTAFFKKPDVNSFYYFTYGNIHKVALLGILGAICGYGGYNRQCLNKEQIYPEFYGKLKDINIGIVPKNEKGYIDKKIQVFNNSVGYASKELGGNLIVKEQWLENPKWDIYILMDENVPKDLEDRLLNFKFKYIPYLGKNDHMANITDVEYLENIEKLDNTNKLDSIFIKDKYEIQKLDNDLFDMLNDSYKDVCEYKYEEMLPVSLDETTNKYNLETFIYTNSKLKSLTESKTYQCDSKNIFFF
>NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3
MYFKNIEKVNLKDVINKSDKIYAHIGNGKKETLKEHLDLSIKYLCKIYESKSLYNVFLKIENNFLEKFSIEGKEFYRKMLLNTIYMHDLGKINCNFQYRKMGNKEFENEEGLKFNNSNHSMLSSIIYINYFFREMGNLKHKEDREFLIVFLLLNSYIISKHHGSLDSFSEFRKRLVENGEEGKRLYTEQMPIFNKIYKEKIFFNENKLNRIFEKYKLILEDETEKNKGFSIELYIYERFLASLLLSCDYYSTSEFKNQKEVEEFGEIKDIEKFYQSFKNTEVYNWIRKYEKNDYGKTDDFSNIDDINVLRNELFLDAEKTMVSNIDKDIFYLEAPTGSGKSNVSFNLSFKMVERFKEINKIFYVYPFNTLVEQNIKTLEKIFKNNEIMKDIAIINSVVPIKIKSSKDNKIKEIDTNEESDILNEDYERALLDRQFLHYPIVLTTHVSIFNYLFGTSKDNLFPLCQIANSIIVLDEIQSYKNRIWKEIITFLACYSRLLNIKIIIMSATLPNLNKLVDGEIKTVNLIENRKKYFENPIFKNRVMVDFSLLEEKENIKEVLFNNVIKNTKAPNKNILVEFITKESAMDFYEKLKDYNKYLQESEKREIELITGDDNRVDRNRIIDKIKSQKNIILVATQVIEAGVDIDMDIGYKDISMLDSEEQFLGRINRSCKNDAQGIVYFFDLDSASNIYKSDIRKEKNINLNFPKIREILINKNFEEFYDYVIKELNKKAGEHNDSSFQTFFLDKIKTLNFKGIEERMKLIDELYKNSVFLNRNITLENEEELCGEDVWNEYIAILKNNKLDYAEKKIKLSQVTANLNYFIYQVPSNDFIYEDRIGDIYYIGDGEKYFEDGKFDRKKFKSIIVDFI
>NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4
MKVNGTLINYYFHCKRQCWLHGNRINLEDNSQDVKIGKAIHEVKKEKGKQTEISIDNIKIDKITKDYLTEVKKSDSDIEAAKWQLLLYLKVLKDKGIERKGKLEFIEKNKSKSTIIIELDENNLSELEDVIKNIENLLIQENPPEVINESKCKKCAYFEYCYI
>NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MGSTRYITSVGELKRKDNSLCFRKNNKNVYIPVENTKEIYCMSEVNINSKLLDFLSQNNIIMHFFNYYEGYSGTFYPREHYNSGKLLVKQVETYENRRLEVAKSIVEAIGDNIYELLYHYYKHDKKEVKETLDWIKNHSKTNLKKANDIKQIMQVEGETWQRFYGEFKNILPEEFVMNKRVKRPPDNPINALISFGNTLLYGKTITAIYNTHLDQRISFLHEPSEGRFSLSLDISEAFKPVIVFKTIFDLVNNKRIQVSKHFDKKLNYCLLNDEGRNIFITAFEERMESIFLNEKLKRKISYKTAIKLDCYKLIKFILENKEFKPFSLKERM
>NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2
MSKNFNYNYAFVFYDVNEKRVNRVFKTCKKYLSHFQKSVFRGELTPANFILLKKDLNKVINEDEDFICIIKLMNNKVYDEEILGNPHSCTGEDLIL
>NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase
MKKRFNVTGTCIPERHYMVDISNKLDSILKLVNNEEYFIINRPRQYGKTTTLYMLERYLNKFKDYLVISISFEGIGDLIFQDEKVFSKEFLQIMSDSLLLNSQALSECLEEQKPHVENFIDLSRVITKFIVKAKRKVVLMIDEVDKSSNNQLFLSFLGLLRNKYLLRNVGKDYTFHNVILAGVHDVKSLKLKIRPDEEHKYNSPWNIASDFDVDMSFSIDEIKTMLDDYVENKEVNLDKEYFAEKIYFYTSGYPFLVSKLCKIVDEKIMVKDELKWEKEYLQIAVKELLKESNTNFDSLIKNIENNKDLQELVRKIILDGYEITYNEDNPLITMGVTYGIFKNSHGKVKIHNRIYEQRIYNYMISLIETKINLGFYTERERYLKPNGDLDIKKVLKKFQEFMKHEYSQKREGFLEEDGRLVFLAFLSPIINGAGFAFKEVQGGEEKRFDIVITYNKKMYILELKIWRGEEYHKKGLKQLVEYLNQYGLEEGYLLIFDFRKATNLIGQVEETHINAEDNIKKIIGVYC
>NC_022777.1|WP_023438413.1|1594021_1595170_-|polysaccharide-deacetylase
MRRKNKFGVILFLMIIITALSIILSDSRGSRQFIKSQKSENMASKNEKNKKKIKSEKYNGEMEFYNGEIEHLFFHPLILDKKAAFTGPKWHTDNMDNWLVTVEESKKVINSLYSKGYILIDPNSLYEEYESDGKKLFRKKPLKVPKGKKPLILSIDDLSYNEGMRKATALKLILDENGNLATYRKDQNGKEIIGYDEIVMILDRFVKEHPDFSLNGAKGVIALTGYEGVFGYRTNLDSKNREEEAKKAKVIANKLKENGWKFASHSYGHLDNAKIPFQTLKRDADKWEQLVKPIIGHTSIYVYPHGTAIKTNSEKFKYLQSKGFKIFYSVDSYLGERISENDLVVEGGRMPIDGLSMRNRREAFLKFFDAKEVLDLESRPKR
>NC_022777.1|WP_023438414.1|1596183_1596507_-|hypothetical-protein
MFNTDDSEISEIITAAIHDSSGIGLEDTSSLKFMILEGDWNNKEIPQCFEGIKSAGESGKIQVLSRGKNLFNKDSIYYLNVVTGKTIRNLSKFGSSFIVVKPNTSYM
>NC_022777.1|WP_155276578.1|1597726_1597885_+|hypothetical-protein
MKLNIKIINAKYIFTFNIAFRIPRTNDIAGYAKNIKSIINPLKVSLPYLKII
>NC_022777.1|WP_023438418.1|1598095_1599184_-|amidase-domain-containing-protein
MKKKLMELKSKLDYGSLKNAYIIKGDEITNEDIKALIDNYFNWTYENLINNTIGELQNIVGNNKLVEFKKSKLKWLVNWYGKNEEEIKDYKIYTEINDVDINGNIIYINVIYGEDLILKSNSDIVQKIRNQEHKILAKNVGSKLVIIHDYYNDELADEMFLVSDREFKTNKKVKSINKKLEKKTLEINKNIKKIDKLVKQYKRNLHNTLQINNIQERKYPGYDGIAAAKYAVKYAINYNPEYQDYNGRGGDCTNFISQCIYAGGIPTDNVWYKDSHAWIRVVELRSWLLKKGYARELTVQDNAKKGDLIQLRNSGGYWYHSLIVTYKNSSNGELFVSCHTGDYVNRALSTYTTDRRYLILTS
>NC_022777.1|WP_011099692.1|1599348_1599906_+|hypothetical-protein
MIKTKKKVFANVSFTVLLLVLINTSVFAAYPSKATMDNTWGFEKGDSTEKQLIYHQHGDLDWKGHVDFAMNEININPADISCYYGTSEDLANIVVTSNYWPDATWSGSTYAPIGLEPKTIELNSSAELTDWQRDAVTTHEFVHIWGINDSRNKNSISYGFTPVNYRTITDDVTTLLKNRYNEEVK
>NC_022777.1|WP_011099693.1|1599906_1600500_+|hypothetical-protein
MIKKISVILALTGVINTNSALSTPPSKVNEPIKPKASASYMEIDGLKELKAKSDIIVEVEGTDKFELIDYKGIKMRKTTVKILDVMKGNPTLKEITVVQTEGLESEEPPMKNEKLLMFLRKGIDITDSYVPIGGNQGIYKIITKKTKKNSMTPKKLPHLNAPKDDAIKIVTPTSLINNKILRDLNGNYDDIKKKLIE
>NC_022777.1|WP_080744613.1|1600510_1601818_-|S41-family-peptidase
MKMKRFKKITILAVVLIILILSKSFIGKAYYKKNAPEHIKNFSKKEALEDYDYMWNVLERNYPCFNVIERKHGVTIKDIKNGYRKRIENRENVDFKYFNMILNKSINKFSDVGHLYVMDFNFYIMLRGTFDAISKNEIGGIVKNNFEMAINKKTEETYKHIYNISYGKKILKNLNFTNISNKLYDNKNLSFKEIDKDTAYIKINNFYHYNIANDKDKLINFYRKNSDKKNLVIDLTENRGGSDSYWMTNIVAPNIDKELKLYNQYALYKNGDIVNDQWVKKHGNNEYREITKDFSEVLKLSKIRKEDLKDLKYLEISKSIPYNVKPSSKKKLFKGKIYVLVSEQVQSSGEDFVEYCKNTKFATLIGTNTGGNSPAMSPVYDVLPNSGLLLMYQIDYKLNPDGTCNTEFGLPPDIVSKENEEPLDTFKRVILEKKL
>NC_022777.1|WP_023438420.1|1601929_1602112_+|hypothetical-protein
MILLLISMLSSKIFDIIFFNLLGETTGTLGSIIGFVLPYSIALEIILKKLFFEPSSKDSK
>NC_022777.1|WP_023438421.1|1602272_1604000_+|histidine-decarboxylase
MKNPMTQPTKDPNTVYPKVPGIDYDKFKLSEDKMTSKQINDALEELHNYISNQQTNFLGYQINQSFNYMKDLKEYLNVHMNNIGDPFVSGNFTVNTKFLERAVLDYFASLWNAQWPHESKGDSNTNDWKNSYWGYVVSMGSTEANFFGIWNARDYLSGKALLLDTSTHKRAKSASVNGNPQSVEPRVLNYQAKSLEDNPNMYTPIAFYSQDTHYSIIKGMRILNFTTFNEAGSGKFECPLKYPEDYPKGFSINYLDENGWPFEVPSNNDGSVFIPALKKLVEAFASKGYPIFVNFNYGTTFKGSYDNVEKAINELVPILKKYNLYEREIIFDKNNKNSDTRTGFWFHVDGALGAAYMPFLEMTTDNEDFPVFDFRLKDVHSISMSGHKWIGVPWPCGIYMSKIKYQLLPPDNPNYIGSPDSTFAGSRNAFSALILWYYIATHSYEDCKNMILDCQDTAKYTVEKLNELSKKLGINLWVEYSSKSLTIRFKEANPDIVFKYSLSGEILYVNGEKRAYSHIYIMPHVTKDLIDKFIEDLSKPGAFPEQVSHLEKDGVNFNSNSHKGIYVPQTGRGFK
>NC_022777.1|WP_023438422.1|1604123_1604705_-|TlpA-family-protein-disulfide-reductase
MKKRMKKIILLAVFVITIISLVGCSSDKKDNTSQNSKSIQSTSNAKVFPKFQGEDFEGNTVDEKVFSKHPVTVVNLWFAGCKACVDEMPDLEKMSAEFQKKNVKMLGIDIDSTDDKEEVKKLLKAKGVTYQNLMLKSDKEIDEFLSKISAFPTTFLINRKGEIVGEAIEGAINSPKRIEEINRKIDEIIGQDK

Crispr_ID: NC_022777_7

• CRISPR_ID: NC_022777_7
• CRISPR_location: 1592328-1593005
• CRISPR_type: TypeI-B
• Repeat_type: III-B
• Spacer_info: 10 spacers
• Cas_protein_info: cas6,cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2

Consensus repeat of NC_022777_7

Consensus_repeat	Method
ATTTAAATACAACTCTTGTTATTGTTCAAC	CRISPRCasFinder
ATTTAAATACAACTCTTGTTATTGTTCAAC	CRT
ATTTAAATACAACTCTTGTTATTGTTCAAC	PILER-CR

spacers of NC_022777_7

>7.1|1592358|35|NC_022777|CRISPRCasFinder,CRT
GTGCTGCACTTCTAGAACTTAAATTACATTCCTTT
>7.2|1592423|35|NC_022777|CRISPRCasFinder,CRT
CGATTCCATGGTCTAAAAAAAGAAGATATAAATGA
>7.3|1592488|35|NC_022777|CRISPRCasFinder,CRT
ATTAACCTTAGTAGATAAAAATATAGAAAACAGAA
>7.4|1592553|34|NC_022777|CRISPRCasFinder,CRT
TATTAGAAATACTTAGATTTTTAGGTACAGGGAC
>7.5|1592617|35|NC_022777|CRISPRCasFinder,CRT
AGGCTATGGATTATTAAAGAGTTTAATTTAGATAA
>7.6|1592682|34|NC_022777|CRISPRCasFinder,CRT
TTTTATCATCTAGTCCTTTAAAAATTAAAGTTAG
>7.7|1592746|36|NC_022777|CRISPRCasFinder,CRT
TTTATTTCTTCCTCGGTATCTGCTATAGCAACTATG
>7.8|1592812|35|NC_022777|CRISPRCasFinder,CRT
AAAGATAAGAGAGAAGGATTACTTCCAGAAGTAGC
>7.9|1592877|34|NC_022777|CRISPRCasFinder,CRT
CTAATAGTAGGATAATAATTCAATTCATTTAACA
>7.10|1592941|35|NC_022777|CRISPRCasFinder,CRT
CATTGCTTCTATTTGTACTGCCCTGGTCGATTCAC
>7.11|1592359|35|NC_022777|PILER-CR
GTGCTGCACTTCTAGAACTTAAATTACATTCCTTT
>7.12|1592424|35|NC_022777|PILER-CR
CGATTCCATGGTCTAAAAAAAGAAGATATAAATGA
>7.13|1592489|35|NC_022777|PILER-CR
ATTAACCTTAGTAGATAAAAATATAGAAAACAGAA
>7.14|1592554|34|NC_022777|PILER-CR
TATTAGAAATACTTAGATTTTTAGGTACAGGGAC
>7.15|1592618|35|NC_022777|PILER-CR
AGGCTATGGATTATTAAAGAGTTTAATTTAGATAA
>7.16|1592683|34|NC_022777|PILER-CR
TTTTATCATCTAGTCCTTTAAAAATTAAAGTTAG
>7.17|1592747|36|NC_022777|PILER-CR
TTTATTTCTTCCTCGGTATCTGCTATAGCAACTATG
>7.18|1592813|35|NC_022777|PILER-CR
AAAGATAAGAGAGAAGGATTACTTCCAGAAGTAGC
>7.19|1592878|34|NC_022777|PILER-CR
CTAATAGTAGGATAATAATTCAATTCATTTAACA
>7.20|1592942|35|NC_022777|PILER-CR
CATTGCTTCTATTTGTACTGCCCTGGTCGATTCAC

CRISPR arrays and Neighbor proteins around NC_022777_7

CRISPR arrays

The CRISPR arrays of NC_022777_7

>merge|NC_022777|7|1592328-1593005|CRISPRCasFinder,CRT,PILER-CR
TTTTAAATACAACTCTTGTTATTGTTCAACGTGCTGCACTTCTAGAACTTAAATTACATTCCTTTATTTAAATACAACTCTTGTTATTGTTCAACCGATTCCATGGTCTAAAAAAAGAAGATATAAATGAATTTAAATACAACTCTTGTTATTGTTCAACATTAACCTTAGTAGATAAAAATATAGAAAACAGAAATTTAAATACAACTCTTGTTATTGTTCAACTATTAGAAATACTTAGATTTTTAGGTACAGGGACATTTAAATACAACTCTTGTTATTGTTCAACAGGCTATGGATTATTAAAGAGTTTAATTTAGATAAATTTAAATACAACTCTTGTTATTGTTCAACTTTTATCATCTAGTCCTTTAAAAATTAAAGTTAGATTTAAATACAACTCTTGTTATTGTTCAACTTTATTTCTTCCTCGGTATCTGCTATAGCAACTATGATTTAAATACAACTCTTGTTATTGTTCAACAAAGATAAGAGAGAAGGATTACTTCCAGAAGTAGCATTTAAATACAACTCTTGTTATTGTTCAACCTAATAGTAGGATAATAATTCAATTCATTTAACAATTTAAATACAACTCTTGTTATTGTTCAACCATTGCTTCTATTTGTACTGCCCTGGTCGATTCACATTTAAATACAACTCTTGTTATTGTTCAAC

>NC_022777|7|7|1592328-1593005|CRISPRCasFinder
TTTTAAATACAACTCTTGTTATTGTTCAAC	GTGCTGCACTTCTAGAACTTAAATTACATTCCTTT
ATTTAAATACAACTCTTGTTATTGTTCAAC	CGATTCCATGGTCTAAAAAAAGAAGATATAAATGA
ATTTAAATACAACTCTTGTTATTGTTCAAC	ATTAACCTTAGTAGATAAAAATATAGAAAACAGAA
ATTTAAATACAACTCTTGTTATTGTTCAAC	TATTAGAAATACTTAGATTTTTAGGTACAGGGAC
ATTTAAATACAACTCTTGTTATTGTTCAAC	AGGCTATGGATTATTAAAGAGTTTAATTTAGATAA
ATTTAAATACAACTCTTGTTATTGTTCAAC	TTTTATCATCTAGTCCTTTAAAAATTAAAGTTAG
ATTTAAATACAACTCTTGTTATTGTTCAAC	TTTATTTCTTCCTCGGTATCTGCTATAGCAACTATG
ATTTAAATACAACTCTTGTTATTGTTCAAC	AAAGATAAGAGAGAAGGATTACTTCCAGAAGTAGC
ATTTAAATACAACTCTTGTTATTGTTCAAC	CTAATAGTAGGATAATAATTCAATTCATTTAACA
ATTTAAATACAACTCTTGTTATTGTTCAAC	CATTGCTTCTATTTGTACTGCCCTGGTCGATTCAC
ATTTAAATACAACTCTTGTTATTGTTCAAC

>NC_022777|7|6|1592328-1593005|CRT
TTTTAAATACAACTCTTGTTATTGTTCAAC	GTGCTGCACTTCTAGAACTTAAATTACATTCCTTT
ATTTAAATACAACTCTTGTTATTGTTCAAC	CGATTCCATGGTCTAAAAAAAGAAGATATAAATGA
ATTTAAATACAACTCTTGTTATTGTTCAAC	ATTAACCTTAGTAGATAAAAATATAGAAAACAGAA
ATTTAAATACAACTCTTGTTATTGTTCAAC	TATTAGAAATACTTAGATTTTTAGGTACAGGGAC
ATTTAAATACAACTCTTGTTATTGTTCAAC	AGGCTATGGATTATTAAAGAGTTTAATTTAGATAA
ATTTAAATACAACTCTTGTTATTGTTCAAC	TTTTATCATCTAGTCCTTTAAAAATTAAAGTTAG
ATTTAAATACAACTCTTGTTATTGTTCAAC	TTTATTTCTTCCTCGGTATCTGCTATAGCAACTATG
ATTTAAATACAACTCTTGTTATTGTTCAAC	AAAGATAAGAGAGAAGGATTACTTCCAGAAGTAGC
ATTTAAATACAACTCTTGTTATTGTTCAAC	CTAATAGTAGGATAATAATTCAATTCATTTAACA
ATTTAAATACAACTCTTGTTATTGTTCAAC	CATTGCTTCTATTTGTACTGCCCTGGTCGATTCAC
ATTTAAATACAACTCTTGTTATTGTTCAAC

>NC_022777|7|7|1592329-1593005|PILER-CR
TTTAAATACAACTCTTGTTATTGTTCAACG	TGCTGCACTTCTAGAACTTAAATTACATTCCTTTA
TTTAAATACAACTCTTGTTATTGTTCAACC	GATTCCATGGTCTAAAAAAAGAAGATATAAATGAA
TTTAAATACAACTCTTGTTATTGTTCAACA	TTAACCTTAGTAGATAAAAATATAGAAAACAGAAA
TTTAAATACAACTCTTGTTATTGTTCAACT	ATTAGAAATACTTAGATTTTTAGGTACAGGGACA
TTTAAATACAACTCTTGTTATTGTTCAACA	GGCTATGGATTATTAAAGAGTTTAATTTAGATAAA
TTTAAATACAACTCTTGTTATTGTTCAACT	TTTATCATCTAGTCCTTTAAAAATTAAAGTTAGA
TTTAAATACAACTCTTGTTATTGTTCAACT	TTATTTCTTCCTCGGTATCTGCTATAGCAACTATGA
TTTAAATACAACTCTTGTTATTGTTCAACA	AAGATAAGAGAGAAGGATTACTTCCAGAAGTAGCA
TTTAAATACAACTCTTGTTATTGTTCAACC	TAATAGTAGGATAATAATTCAATTCATTTAACAA
TTTAAATACAACTCTTGTTATTGTTCAACC	ATTGCTTCTATTTGTACTGCCCTGGTCGATTCACA
TTTAAATACAACTCTTGTTATTGTTCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022777.1|WP_155276578.1|1597726_1597885_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438420.1|1601929_1602112_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438414.1|1596183_1596507_-|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl|CDD|188234
NC_022777.1|WP_023438418.1|1598095_1599184_-|amidase-domain-containing-protein	unknown	unknown	gnl|CDD|378910
NC_022777.1|WP_011099693.1|1599906_1600500_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|313108
NC_022777.1|WP_023438421.1|1602272_1604000_+|histidine-decarboxylase	unknown	unknown	gnl|CDD|235068
NC_022777.1|WP_023438408.1|1589704_1589851_-|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438413.1|1594021_1595170_-|polysaccharide-deacetylase	unknown	unknown	gnl|CDD|213022
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl|CDD|131641
NC_022777.1|WP_023438422.1|1604123_1604705_-|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl|CDD|239264
NC_022777.1|WP_011099692.1|1599348_1599906_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl|CDD|187770
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_022777.1|WP_080744613.1|1600510_1601818_-|S41-family-peptidase	unknown	unknown	gnl|CDD|367567
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	3.3e-47	155.9	10.5
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	cas8b1	mkCas0106_cas8b1_CAS-I-B	9.1e-190	627.1	73.3
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	1.9e-28	94.5	1.0
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	1.6e-91	300.8	4.1
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.8e-27	90.2	0.2
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	2.3e-50	165.6	7.4
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	2.1e-23	78.4	8.7
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	4.2e-132	434.9	15.7

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	gnl|CDD|188234	TIGR02591, cas_Csh1, CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI. This domain is found in the C-terminal 2/3 of a family of CRISPR associated proteins of the Hmari subtype. Except for the two sequences from halophilic archaea this domain contains a pair of CXXC motifs.	1.46816e-84
NC_022777.1|WP_023438418.1|1598095_1599184_-|amidase-domain-containing-protein	gnl|CDD|378910	pfam12671, Amidase_6, Putative amidase domain.	1.21538e-30
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.45511e-22
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.17517e-60
NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase	gnl|CDD|313108	pfam09820, AAA-ATPase_like, Predicted AAA-ATPase. This family contains many hypothetical bacterial proteins. This family was previously the N-terminal part of the Pfam DUF1703 (pfam08011) family before it was split into two. This region is predicted to be an AAA-ATPase domain.	5.17626e-07
NC_022777.1|WP_023438421.1|1602272_1604000_+|histidine-decarboxylase	gnl|CDD|235068	PRK02769, PRK02769, histidine decarboxylase; Provisional.	4.54756e-68
NC_022777.1|WP_023438413.1|1594021_1595170_-|polysaccharide-deacetylase	gnl|CDD|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	0.000167005
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	gnl|CDD|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.0638e-96
NC_022777.1|WP_023438422.1|1604123_1604705_-|TlpA-family-protein-disulfide-reductase	gnl|CDD|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	3.70776e-27
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.41443e-49
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.04177e-29
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.13188e-163
NC_022777.1|WP_080744613.1|1600510_1601818_-|S41-family-peptidase	gnl|CDD|367567	pfam03572, Peptidase_S41, Peptidase family S41.	9.86301e-25
NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.34287e-28

Protein sequences

>NC_022777.1|WP_023438408.1|1589704_1589851_-|hypothetical-protein
MKKKLKFSISATYEDLKEKERIEIDDIIYIIELVSVITLILKIFQFKN
>NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6
MKIYELTLKVFLLKDIKSDESLEKISNLIDKSLSKDGKLLDFHERNTYKNYTFNSLYPIEKDKIYNEGKIYSVQIRTVDESLIQYFKKNLTNEYTEYIKALTLECRVIPQRYIEKIYSITPVIIKTEKGYWKGNLSLGEFEERIKNNLIKKYNSFFNTKIDERFTLFRAINLINNKPISCSYKDINILGDKITLIIDENEMAQKLACFSLGSGVGEMNARGYGFVNYKWL
>NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1
MLKDVISIFKREYEKIGDRYVTESYIPSDGEYIIVDTFENDFKILDKVIIKKDRKTQKIDDSNQYFPFIREADYLSRLLDMNKPIDHKKIIHSNNYLSFFIKKENVNNGKLSDEIIDRYYEILKDPLIKYKNTKAEKLYEEVEEEHGKVNEKLIDEIKNWIKEKIHDFVDKGSKEKEYLKIFFKYDLDKYRKESEKYISPNLYNSNDYNVKIKEEIYGLPNDNMGLNSKKPYLENKTRKSKVPYLISKEEVLIQKKFFDYLMNQVAIGKSNIYINEKGIKGISNKETLGEDFTGYYLRIQKGKEVEIHNFDTIVNYRAKIEPFKLENVLELEKSELNYNVFIYEIGKLKDLIDNVFFYKFLSGNFFTEAKDLNINDATLKRSILLSRDTLFTWFYKGIDNNVWKNLNISSLNLIKGSINKGYLLKAGEQFNLRSSLKNYFEGGISMADVLLEIKNSLREKINKTSKENKNNEDVTLDNDKEYYFAVGQLAYYLISLSKSKNKNHSLVNPIINAKTNERIKDEIRRLYTRYNYRIEFGSKRVERLYSMISSYIPKGKINEDLIIAGFLKNNLIYEKSEEE
>NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7
MGMNKRVYGVLGIVSRMSNWNADFTGYPKTTSSGDVFGSDKAFKYPMKKMWENGGEKVLYIKSIKFQENKKKERELIPRTLKERYEYIFDVEDLKKNKDSEEVLKNLFTAIDVKNFGATFAEEGNNISITGAVQIGQGFNKYKETYAEEQQILSPFRDPNQKEKSKDGEEAKSSTLGTKIVSNEAHYFYPFVVNPSSYNQFEEIGVTNGYTEEDYKKFKEASMIAATSFNTNSKIGCENEFALFVETKEDLYLPDLSQYVDFEKVEDKNIITLSCSELLNSFEDEIENIEIYYNPYTTEIKLDEIKKAKKFNIFTKKEV
>NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5
MDALKFSLSGRTAFFKKPDVNSFYYFTYGNIHKVALLGILGAICGYGGYNRQCLNKEQIYPEFYGKLKDINIGIVPKNEKGYIDKKIQVFNNSVGYASKELGGNLIVKEQWLENPKWDIYILMDENVPKDLEDRLLNFKFKYIPYLGKNDHMANITDVEYLENIEKLDNTNKLDSIFIKDKYEIQKLDNDLFDMLNDSYKDVCEYKYEEMLPVSLDETTNKYNLETFIYTNSKLKSLTESKTYQCDSKNIFFF
>NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3
MYFKNIEKVNLKDVINKSDKIYAHIGNGKKETLKEHLDLSIKYLCKIYESKSLYNVFLKIENNFLEKFSIEGKEFYRKMLLNTIYMHDLGKINCNFQYRKMGNKEFENEEGLKFNNSNHSMLSSIIYINYFFREMGNLKHKEDREFLIVFLLLNSYIISKHHGSLDSFSEFRKRLVENGEEGKRLYTEQMPIFNKIYKEKIFFNENKLNRIFEKYKLILEDETEKNKGFSIELYIYERFLASLLLSCDYYSTSEFKNQKEVEEFGEIKDIEKFYQSFKNTEVYNWIRKYEKNDYGKTDDFSNIDDINVLRNELFLDAEKTMVSNIDKDIFYLEAPTGSGKSNVSFNLSFKMVERFKEINKIFYVYPFNTLVEQNIKTLEKIFKNNEIMKDIAIINSVVPIKIKSSKDNKIKEIDTNEESDILNEDYERALLDRQFLHYPIVLTTHVSIFNYLFGTSKDNLFPLCQIANSIIVLDEIQSYKNRIWKEIITFLACYSRLLNIKIIIMSATLPNLNKLVDGEIKTVNLIENRKKYFENPIFKNRVMVDFSLLEEKENIKEVLFNNVIKNTKAPNKNILVEFITKESAMDFYEKLKDYNKYLQESEKREIELITGDDNRVDRNRIIDKIKSQKNIILVATQVIEAGVDIDMDIGYKDISMLDSEEQFLGRINRSCKNDAQGIVYFFDLDSASNIYKSDIRKEKNINLNFPKIREILINKNFEEFYDYVIKELNKKAGEHNDSSFQTFFLDKIKTLNFKGIEERMKLIDELYKNSVFLNRNITLENEEELCGEDVWNEYIAILKNNKLDYAEKKIKLSQVTANLNYFIYQVPSNDFIYEDRIGDIYYIGDGEKYFEDGKFDRKKFKSIIVDFI
>NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4
MKVNGTLINYYFHCKRQCWLHGNRINLEDNSQDVKIGKAIHEVKKEKGKQTEISIDNIKIDKITKDYLTEVKKSDSDIEAAKWQLLLYLKVLKDKGIERKGKLEFIEKNKSKSTIIIELDENNLSELEDVIKNIENLLIQENPPEVINESKCKKCAYFEYCYI
>NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MGSTRYITSVGELKRKDNSLCFRKNNKNVYIPVENTKEIYCMSEVNINSKLLDFLSQNNIIMHFFNYYEGYSGTFYPREHYNSGKLLVKQVETYENRRLEVAKSIVEAIGDNIYELLYHYYKHDKKEVKETLDWIKNHSKTNLKKANDIKQIMQVEGETWQRFYGEFKNILPEEFVMNKRVKRPPDNPINALISFGNTLLYGKTITAIYNTHLDQRISFLHEPSEGRFSLSLDISEAFKPVIVFKTIFDLVNNKRIQVSKHFDKKLNYCLLNDEGRNIFITAFEERMESIFLNEKLKRKISYKTAIKLDCYKLIKFILENKEFKPFSLKERM
>NC_022777.1|WP_023438399.1|1580943_1581234_-|CRISPR-associated-endonuclease-Cas2
MSKNFNYNYAFVFYDVNEKRVNRVFKTCKKYLSHFQKSVFRGELTPANFILLKKDLNKVINEDEDFICIIKLMNNKVYDEEILGNPHSCTGEDLIL
>NC_022777.1|WP_011099679.1|1578782_1580366_-|AAA-family-ATPase
MKKRFNVTGTCIPERHYMVDISNKLDSILKLVNNEEYFIINRPRQYGKTTTLYMLERYLNKFKDYLVISISFEGIGDLIFQDEKVFSKEFLQIMSDSLLLNSQALSECLEEQKPHVENFIDLSRVITKFIVKAKRKVVLMIDEVDKSSNNQLFLSFLGLLRNKYLLRNVGKDYTFHNVILAGVHDVKSLKLKIRPDEEHKYNSPWNIASDFDVDMSFSIDEIKTMLDDYVENKEVNLDKEYFAEKIYFYTSGYPFLVSKLCKIVDEKIMVKDELKWEKEYLQIAVKELLKESNTNFDSLIKNIENNKDLQELVRKIILDGYEITYNEDNPLITMGVTYGIFKNSHGKVKIHNRIYEQRIYNYMISLIETKINLGFYTERERYLKPNGDLDIKKVLKKFQEFMKHEYSQKREGFLEEDGRLVFLAFLSPIINGAGFAFKEVQGGEEKRFDIVITYNKKMYILELKIWRGEEYHKKGLKQLVEYLNQYGLEEGYLLIFDFRKATNLIGQVEETHINAEDNIKKIIGVYC
>NC_022777.1|WP_023438413.1|1594021_1595170_-|polysaccharide-deacetylase
MRRKNKFGVILFLMIIITALSIILSDSRGSRQFIKSQKSENMASKNEKNKKKIKSEKYNGEMEFYNGEIEHLFFHPLILDKKAAFTGPKWHTDNMDNWLVTVEESKKVINSLYSKGYILIDPNSLYEEYESDGKKLFRKKPLKVPKGKKPLILSIDDLSYNEGMRKATALKLILDENGNLATYRKDQNGKEIIGYDEIVMILDRFVKEHPDFSLNGAKGVIALTGYEGVFGYRTNLDSKNREEEAKKAKVIANKLKENGWKFASHSYGHLDNAKIPFQTLKRDADKWEQLVKPIIGHTSIYVYPHGTAIKTNSEKFKYLQSKGFKIFYSVDSYLGERISENDLVVEGGRMPIDGLSMRNRREAFLKFFDAKEVLDLESRPKR
>NC_022777.1|WP_023438414.1|1596183_1596507_-|hypothetical-protein
MFNTDDSEISEIITAAIHDSSGIGLEDTSSLKFMILEGDWNNKEIPQCFEGIKSAGESGKIQVLSRGKNLFNKDSIYYLNVVTGKTIRNLSKFGSSFIVVKPNTSYM
>NC_022777.1|WP_155276578.1|1597726_1597885_+|hypothetical-protein
MKLNIKIINAKYIFTFNIAFRIPRTNDIAGYAKNIKSIINPLKVSLPYLKII
>NC_022777.1|WP_023438418.1|1598095_1599184_-|amidase-domain-containing-protein
MKKKLMELKSKLDYGSLKNAYIIKGDEITNEDIKALIDNYFNWTYENLINNTIGELQNIVGNNKLVEFKKSKLKWLVNWYGKNEEEIKDYKIYTEINDVDINGNIIYINVIYGEDLILKSNSDIVQKIRNQEHKILAKNVGSKLVIIHDYYNDELADEMFLVSDREFKTNKKVKSINKKLEKKTLEINKNIKKIDKLVKQYKRNLHNTLQINNIQERKYPGYDGIAAAKYAVKYAINYNPEYQDYNGRGGDCTNFISQCIYAGGIPTDNVWYKDSHAWIRVVELRSWLLKKGYARELTVQDNAKKGDLIQLRNSGGYWYHSLIVTYKNSSNGELFVSCHTGDYVNRALSTYTTDRRYLILTS
>NC_022777.1|WP_011099692.1|1599348_1599906_+|hypothetical-protein
MIKTKKKVFANVSFTVLLLVLINTSVFAAYPSKATMDNTWGFEKGDSTEKQLIYHQHGDLDWKGHVDFAMNEININPADISCYYGTSEDLANIVVTSNYWPDATWSGSTYAPIGLEPKTIELNSSAELTDWQRDAVTTHEFVHIWGINDSRNKNSISYGFTPVNYRTITDDVTTLLKNRYNEEVK
>NC_022777.1|WP_011099693.1|1599906_1600500_+|hypothetical-protein
MIKKISVILALTGVINTNSALSTPPSKVNEPIKPKASASYMEIDGLKELKAKSDIIVEVEGTDKFELIDYKGIKMRKTTVKILDVMKGNPTLKEITVVQTEGLESEEPPMKNEKLLMFLRKGIDITDSYVPIGGNQGIYKIITKKTKKNSMTPKKLPHLNAPKDDAIKIVTPTSLINNKILRDLNGNYDDIKKKLIE
>NC_022777.1|WP_080744613.1|1600510_1601818_-|S41-family-peptidase
MKMKRFKKITILAVVLIILILSKSFIGKAYYKKNAPEHIKNFSKKEALEDYDYMWNVLERNYPCFNVIERKHGVTIKDIKNGYRKRIENRENVDFKYFNMILNKSINKFSDVGHLYVMDFNFYIMLRGTFDAISKNEIGGIVKNNFEMAINKKTEETYKHIYNISYGKKILKNLNFTNISNKLYDNKNLSFKEIDKDTAYIKINNFYHYNIANDKDKLINFYRKNSDKKNLVIDLTENRGGSDSYWMTNIVAPNIDKELKLYNQYALYKNGDIVNDQWVKKHGNNEYREITKDFSEVLKLSKIRKEDLKDLKYLEISKSIPYNVKPSSKKKLFKGKIYVLVSEQVQSSGEDFVEYCKNTKFATLIGTNTGGNSPAMSPVYDVLPNSGLLLMYQIDYKLNPDGTCNTEFGLPPDIVSKENEEPLDTFKRVILEKKL
>NC_022777.1|WP_023438420.1|1601929_1602112_+|hypothetical-protein
MILLLISMLSSKIFDIIFFNLLGETTGTLGSIIGFVLPYSIALEIILKKLFFEPSSKDSK
>NC_022777.1|WP_023438421.1|1602272_1604000_+|histidine-decarboxylase
MKNPMTQPTKDPNTVYPKVPGIDYDKFKLSEDKMTSKQINDALEELHNYISNQQTNFLGYQINQSFNYMKDLKEYLNVHMNNIGDPFVSGNFTVNTKFLERAVLDYFASLWNAQWPHESKGDSNTNDWKNSYWGYVVSMGSTEANFFGIWNARDYLSGKALLLDTSTHKRAKSASVNGNPQSVEPRVLNYQAKSLEDNPNMYTPIAFYSQDTHYSIIKGMRILNFTTFNEAGSGKFECPLKYPEDYPKGFSINYLDENGWPFEVPSNNDGSVFIPALKKLVEAFASKGYPIFVNFNYGTTFKGSYDNVEKAINELVPILKKYNLYEREIIFDKNNKNSDTRTGFWFHVDGALGAAYMPFLEMTTDNEDFPVFDFRLKDVHSISMSGHKWIGVPWPCGIYMSKIKYQLLPPDNPNYIGSPDSTFAGSRNAFSALILWYYIATHSYEDCKNMILDCQDTAKYTVEKLNELSKKLGINLWVEYSSKSLTIRFKEANPDIVFKYSLSGEILYVNGEKRAYSHIYIMPHVTKDLIDKFIEDLSKPGAFPEQVSHLEKDGVNFNSNSHKGIYVPQTGRGFK
>NC_022777.1|WP_023438422.1|1604123_1604705_-|TlpA-family-protein-disulfide-reductase
MKKRMKKIILLAVFVITIISLVGCSSDKKDNTSQNSKSIQSTSNAKVFPKFQGEDFEGNTVDEKVFSKHPVTVVNLWFAGCKACVDEMPDLEKMSAEFQKKNVKMLGIDIDSTDDKEEVKKLLKAKGVTYQNLMLKSDKEIDEFLSKISAFPTTFLINRKGEIVGEAIEGAINSPKRIEEINRKIDEIIGQDK

Crispr_ID: NC_022777_8

• CRISPR_ID: NC_022777_8
• CRISPR_location: 1596528-1596755
• CRISPR_type: TypeI-B
• Repeat_type: III-B
• Spacer_info: 3 spacers
• Cas_protein_info: cas6,cas8b1,cas7b,cas5,cas3,cas4,cas1

Consensus repeat of NC_022777_8

Consensus_repeat	Method
ATTTAAATACAACTCTTGTTATTGTTCAAC	PILER-CR
ATTTAAATACAACTCTTGTTATTGTTCAAC	CRISPRCasFinder
ATTTAAATACAACTCTTGTTATTGTTCAAC	CRT

spacers of NC_022777_8

>8.1|1596558|37|NC_022777|PILER-CR,CRISPRCasFinder,CRT
TTGCAAAACAATATGGGAATGGAAAACCTAAAGACAA
>8.2|1596625|34|NC_022777|PILER-CR,CRISPRCasFinder,CRT
AAAATCTTCTATTACTCCATACCCCCATACTGAC
>8.3|1596689|37|NC_022777|PILER-CR,CRISPRCasFinder,CRT
GCTTGTTTCTGGATTCAAACAGATCCAGATCAATCCA

CRISPR arrays and Neighbor proteins around NC_022777_8

CRISPR arrays

The CRISPR arrays of NC_022777_8

>merge|NC_022777|8|1596528-1596755|PILER-CR,CRISPRCasFinder,CRT
ATTTAAATACAACTCTTGTTATTGTTCAACTTGCAAAACAATATGGGAATGGAAAACCTAAAGACAAATTTAAATACAACTCTTGTTATTGTTCAACAAAATCTTCTATTACTCCATACCCCCATACTGACATTTAAATACAACTCTTGTTATTGTTCAACGCTTGTTTCTGGATTCAAACAGATCCAGATCAATCCAATTTAAATACAACTCTTGTTATTGTTCAAC

>NC_022777|8|8|1596528-1596755|PILER-CR
ATTTAAATACAACTCTTGTTATTGTTCAAC	TTGCAAAACAATATGGGAATGGAAAACCTAAAGACAA
ATTTAAATACAACTCTTGTTATTGTTCAAC	AAAATCTTCTATTACTCCATACCCCCATACTGAC
ATTTAAATACAACTCTTGTTATTGTTCAAC	GCTTGTTTCTGGATTCAAACAGATCCAGATCAATCCA
ATTTAAATACAACTCTTGTTATTGTTCAAC

>NC_022777|8|8|1596528-1596755|CRISPRCasFinder
ATTTAAATACAACTCTTGTTATTGTTCAAC	TTGCAAAACAATATGGGAATGGAAAACCTAAAGACAA
ATTTAAATACAACTCTTGTTATTGTTCAAC	AAAATCTTCTATTACTCCATACCCCCATACTGAC
ATTTAAATACAACTCTTGTTATTGTTCAAC	GCTTGTTTCTGGATTCAAACAGATCCAGATCAATCCA
ATTTAAATACAACTCTTGTTATTGTTCAAC

>NC_022777|8|7|1596528-1596755|CRT
ATTTAAATACAACTCTTGTTATTGTTCAAC	TTGCAAAACAATATGGGAATGGAAAACCTAAAGACAA
ATTTAAATACAACTCTTGTTATTGTTCAAC	AAAATCTTCTATTACTCCATACCCCCATACTGAC
ATTTAAATACAACTCTTGTTATTGTTCAAC	GCTTGTTTCTGGATTCAAACAGATCCAGATCAATCCA
ATTTAAATACAACTCTTGTTATTGTTCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022777.1|WP_155276578.1|1597726_1597885_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438420.1|1601929_1602112_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438424.1|1605637_1605787_-|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl|CDD|188234
NC_022777.1|WP_023438414.1|1596183_1596507_-|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438418.1|1598095_1599184_-|amidase-domain-containing-protein	unknown	unknown	gnl|CDD|378910
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NC_022777.1|WP_011099693.1|1599906_1600500_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438421.1|1602272_1604000_+|histidine-decarboxylase	unknown	unknown	gnl|CDD|235068
NC_022777.1|WP_023438408.1|1589704_1589851_-|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438413.1|1594021_1595170_-|polysaccharide-deacetylase	unknown	unknown	gnl|CDD|213022
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl|CDD|131641
NC_022777.1|WP_023438422.1|1604123_1604705_-|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl|CDD|239264
NC_022777.1|WP_011099692.1|1599348_1599906_+|hypothetical-protein	unknown	unknown	unknown
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl|CDD|187770
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_022777.1|WP_080744613.1|1600510_1601818_-|S41-family-peptidase	unknown	unknown	gnl|CDD|367567
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_022777.1|WP_045923598.1|1604769_1605684_-|4Fe-4S-binding-protein	unknown	unknown	gnl|CDD|274004

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	3.3e-47	155.9	10.5
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	cas8b1	mkCas0106_cas8b1_CAS-I-B	9.1e-190	627.1	73.3
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	1.9e-28	94.5	1.0
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	1.6e-91	300.8	4.1
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	2.3e-50	165.6	7.4
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	2.1e-23	78.4	8.7
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	4.2e-132	434.9	15.7

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1	gnl|CDD|188234	TIGR02591, cas_Csh1, CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI. This domain is found in the C-terminal 2/3 of a family of CRISPR associated proteins of the Hmari subtype. Except for the two sequences from halophilic archaea this domain contains a pair of CXXC motifs.	1.46816e-84
NC_022777.1|WP_023438418.1|1598095_1599184_-|amidase-domain-containing-protein	gnl|CDD|378910	pfam12671, Amidase_6, Putative amidase domain.	1.21538e-30
NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.17517e-60
NC_022777.1|WP_023438421.1|1602272_1604000_+|histidine-decarboxylase	gnl|CDD|235068	PRK02769, PRK02769, histidine decarboxylase; Provisional.	4.54756e-68
NC_022777.1|WP_080744613.1|1600510_1601818_-|S41-family-peptidase	gnl|CDD|367567	pfam03572, Peptidase_S41, Peptidase family S41.	9.86301e-25
NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5	gnl|CDD|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.0638e-96
NC_022777.1|WP_023438422.1|1604123_1604705_-|TlpA-family-protein-disulfide-reductase	gnl|CDD|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	3.70776e-27
NC_022777.1|WP_045923598.1|1604769_1605684_-|4Fe-4S-binding-protein	gnl|CDD|274004	TIGR02163, Ferredoxin-type_protein_NapH_homolog, ferredoxin-type protein, NapH/MauN family. Most members of this family are the NapH protein, found next to NapG,in operons that encode the periplasmic nitrate reductase. Some species with this reductase lack NapC but accomplish electron transfer to NapAB in some other manner, likely to involve NapH, NapG, and/or some other protein. A few members of this protein are designated MauN and are found in methylamine utilization operons in species that appear to lack a periplasmic nitrate reductase.	1.47259e-19
NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.41443e-49
NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.04177e-29
NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.13188e-163
NC_022777.1|WP_023438413.1|1594021_1595170_-|polysaccharide-deacetylase	gnl|CDD|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	0.000167005
NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.45511e-22

Protein sequences

>NC_022777.1|WP_023438414.1|1596183_1596507_-|hypothetical-protein
MFNTDDSEISEIITAAIHDSSGIGLEDTSSLKFMILEGDWNNKEIPQCFEGIKSAGESGKIQVLSRGKNLFNKDSIYYLNVVTGKTIRNLSKFGSSFIVVKPNTSYM
>NC_022777.1|WP_023438413.1|1594021_1595170_-|polysaccharide-deacetylase
MRRKNKFGVILFLMIIITALSIILSDSRGSRQFIKSQKSENMASKNEKNKKKIKSEKYNGEMEFYNGEIEHLFFHPLILDKKAAFTGPKWHTDNMDNWLVTVEESKKVINSLYSKGYILIDPNSLYEEYESDGKKLFRKKPLKVPKGKKPLILSIDDLSYNEGMRKATALKLILDENGNLATYRKDQNGKEIIGYDEIVMILDRFVKEHPDFSLNGAKGVIALTGYEGVFGYRTNLDSKNREEEAKKAKVIANKLKENGWKFASHSYGHLDNAKIPFQTLKRDADKWEQLVKPIIGHTSIYVYPHGTAIKTNSEKFKYLQSKGFKIFYSVDSYLGERISENDLVVEGGRMPIDGLSMRNRREAFLKFFDAKEVLDLESRPKR
>NC_022777.1|WP_023438408.1|1589704_1589851_-|hypothetical-protein
MKKKLKFSISATYEDLKEKERIEIDDIIYIIELVSVITLILKIFQFKN
>NC_022777.1|WP_023438407.1|1588892_1589585_-|CRISPR-associated-endoribonuclease-Cas6
MKIYELTLKVFLLKDIKSDESLEKISNLIDKSLSKDGKLLDFHERNTYKNYTFNSLYPIEKDKIYNEGKIYSVQIRTVDESLIQYFKKNLTNEYTEYIKALTLECRVIPQRYIEKIYSITPVIIKTEKGYWKGNLSLGEFEERIKNNLIKKYNSFFNTKIDERFTLFRAINLINNKPISCSYKDINILGDKITLIIDENEMAQKLACFSLGSGVGEMNARGYGFVNYKWL
>NC_022777.1|WP_023438406.1|1587140_1588880_-|type-I-B-CRISPR-associated-protein-Cas8b/Csh1
MLKDVISIFKREYEKIGDRYVTESYIPSDGEYIIVDTFENDFKILDKVIIKKDRKTQKIDDSNQYFPFIREADYLSRLLDMNKPIDHKKIIHSNNYLSFFIKKENVNNGKLSDEIIDRYYEILKDPLIKYKNTKAEKLYEEVEEEHGKVNEKLIDEIKNWIKEKIHDFVDKGSKEKEYLKIFFKYDLDKYRKESEKYISPNLYNSNDYNVKIKEEIYGLPNDNMGLNSKKPYLENKTRKSKVPYLISKEEVLIQKKFFDYLMNQVAIGKSNIYINEKGIKGISNKETLGEDFTGYYLRIQKGKEVEIHNFDTIVNYRAKIEPFKLENVLELEKSELNYNVFIYEIGKLKDLIDNVFFYKFLSGNFFTEAKDLNINDATLKRSILLSRDTLFTWFYKGIDNNVWKNLNISSLNLIKGSINKGYLLKAGEQFNLRSSLKNYFEGGISMADVLLEIKNSLREKINKTSKENKNNEDVTLDNDKEYYFAVGQLAYYLISLSKSKNKNHSLVNPIINAKTNERIKDEIRRLYTRYNYRIEFGSKRVERLYSMISSYIPKGKINEDLIIAGFLKNNLIYEKSEEE
>NC_022777.1|WP_023438405.1|1586175_1587135_-|type-I-CRISPR-associated-protein-Cas7
MGMNKRVYGVLGIVSRMSNWNADFTGYPKTTSSGDVFGSDKAFKYPMKKMWENGGEKVLYIKSIKFQENKKKERELIPRTLKERYEYIFDVEDLKKNKDSEEVLKNLFTAIDVKNFGATFAEEGNNISITGAVQIGQGFNKYKETYAEEQQILSPFRDPNQKEKSKDGEEAKSSTLGTKIVSNEAHYFYPFVVNPSSYNQFEEIGVTNGYTEEDYKKFKEASMIAATSFNTNSKIGCENEFALFVETKEDLYLPDLSQYVDFEKVEDKNIITLSCSELLNSFEDEIENIEIYYNPYTTEIKLDEIKKAKKFNIFTKKEV
>NC_022777.1|WP_023438404.1|1585410_1586172_-|type-I-B-CRISPR-associated-protein-Cas5
MDALKFSLSGRTAFFKKPDVNSFYYFTYGNIHKVALLGILGAICGYGGYNRQCLNKEQIYPEFYGKLKDINIGIVPKNEKGYIDKKIQVFNNSVGYASKELGGNLIVKEQWLENPKWDIYILMDENVPKDLEDRLLNFKFKYIPYLGKNDHMANITDVEYLENIEKLDNTNKLDSIFIKDKYEIQKLDNDLFDMLNDSYKDVCEYKYEEMLPVSLDETTNKYNLETFIYTNSKLKSLTESKTYQCDSKNIFFF
>NC_022777.1|WP_023438403.1|1582742_1585349_-|CRISPR-associated-helicase/endonuclease-Cas3
MYFKNIEKVNLKDVINKSDKIYAHIGNGKKETLKEHLDLSIKYLCKIYESKSLYNVFLKIENNFLEKFSIEGKEFYRKMLLNTIYMHDLGKINCNFQYRKMGNKEFENEEGLKFNNSNHSMLSSIIYINYFFREMGNLKHKEDREFLIVFLLLNSYIISKHHGSLDSFSEFRKRLVENGEEGKRLYTEQMPIFNKIYKEKIFFNENKLNRIFEKYKLILEDETEKNKGFSIELYIYERFLASLLLSCDYYSTSEFKNQKEVEEFGEIKDIEKFYQSFKNTEVYNWIRKYEKNDYGKTDDFSNIDDINVLRNELFLDAEKTMVSNIDKDIFYLEAPTGSGKSNVSFNLSFKMVERFKEINKIFYVYPFNTLVEQNIKTLEKIFKNNEIMKDIAIINSVVPIKIKSSKDNKIKEIDTNEESDILNEDYERALLDRQFLHYPIVLTTHVSIFNYLFGTSKDNLFPLCQIANSIIVLDEIQSYKNRIWKEIITFLACYSRLLNIKIIIMSATLPNLNKLVDGEIKTVNLIENRKKYFENPIFKNRVMVDFSLLEEKENIKEVLFNNVIKNTKAPNKNILVEFITKESAMDFYEKLKDYNKYLQESEKREIELITGDDNRVDRNRIIDKIKSQKNIILVATQVIEAGVDIDMDIGYKDISMLDSEEQFLGRINRSCKNDAQGIVYFFDLDSASNIYKSDIRKEKNINLNFPKIREILINKNFEEFYDYVIKELNKKAGEHNDSSFQTFFLDKIKTLNFKGIEERMKLIDELYKNSVFLNRNITLENEEELCGEDVWNEYIAILKNNKLDYAEKKIKLSQVTANLNYFIYQVPSNDFIYEDRIGDIYYIGDGEKYFEDGKFDRKKFKSIIVDFI
>NC_022777.1|WP_023438402.1|1582242_1582734_-|CRISPR-associated-protein-Cas4
MKVNGTLINYYFHCKRQCWLHGNRINLEDNSQDVKIGKAIHEVKKEKGKQTEISIDNIKIDKITKDYLTEVKKSDSDIEAAKWQLLLYLKVLKDKGIERKGKLEFIEKNKSKSTIIIELDENNLSELEDVIKNIENLLIQENPPEVINESKCKKCAYFEYCYI
>NC_022777.1|WP_023438400.1|1581234_1582233_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MGSTRYITSVGELKRKDNSLCFRKNNKNVYIPVENTKEIYCMSEVNINSKLLDFLSQNNIIMHFFNYYEGYSGTFYPREHYNSGKLLVKQVETYENRRLEVAKSIVEAIGDNIYELLYHYYKHDKKEVKETLDWIKNHSKTNLKKANDIKQIMQVEGETWQRFYGEFKNILPEEFVMNKRVKRPPDNPINALISFGNTLLYGKTITAIYNTHLDQRISFLHEPSEGRFSLSLDISEAFKPVIVFKTIFDLVNNKRIQVSKHFDKKLNYCLLNDEGRNIFITAFEERMESIFLNEKLKRKISYKTAIKLDCYKLIKFILENKEFKPFSLKERM
>NC_022777.1|WP_155276578.1|1597726_1597885_+|hypothetical-protein
MKLNIKIINAKYIFTFNIAFRIPRTNDIAGYAKNIKSIINPLKVSLPYLKII
>NC_022777.1|WP_023438418.1|1598095_1599184_-|amidase-domain-containing-protein
MKKKLMELKSKLDYGSLKNAYIIKGDEITNEDIKALIDNYFNWTYENLINNTIGELQNIVGNNKLVEFKKSKLKWLVNWYGKNEEEIKDYKIYTEINDVDINGNIIYINVIYGEDLILKSNSDIVQKIRNQEHKILAKNVGSKLVIIHDYYNDELADEMFLVSDREFKTNKKVKSINKKLEKKTLEINKNIKKIDKLVKQYKRNLHNTLQINNIQERKYPGYDGIAAAKYAVKYAINYNPEYQDYNGRGGDCTNFISQCIYAGGIPTDNVWYKDSHAWIRVVELRSWLLKKGYARELTVQDNAKKGDLIQLRNSGGYWYHSLIVTYKNSSNGELFVSCHTGDYVNRALSTYTTDRRYLILTS
>NC_022777.1|WP_011099692.1|1599348_1599906_+|hypothetical-protein
MIKTKKKVFANVSFTVLLLVLINTSVFAAYPSKATMDNTWGFEKGDSTEKQLIYHQHGDLDWKGHVDFAMNEININPADISCYYGTSEDLANIVVTSNYWPDATWSGSTYAPIGLEPKTIELNSSAELTDWQRDAVTTHEFVHIWGINDSRNKNSISYGFTPVNYRTITDDVTTLLKNRYNEEVK
>NC_022777.1|WP_011099693.1|1599906_1600500_+|hypothetical-protein
MIKKISVILALTGVINTNSALSTPPSKVNEPIKPKASASYMEIDGLKELKAKSDIIVEVEGTDKFELIDYKGIKMRKTTVKILDVMKGNPTLKEITVVQTEGLESEEPPMKNEKLLMFLRKGIDITDSYVPIGGNQGIYKIITKKTKKNSMTPKKLPHLNAPKDDAIKIVTPTSLINNKILRDLNGNYDDIKKKLIE
>NC_022777.1|WP_080744613.1|1600510_1601818_-|S41-family-peptidase
MKMKRFKKITILAVVLIILILSKSFIGKAYYKKNAPEHIKNFSKKEALEDYDYMWNVLERNYPCFNVIERKHGVTIKDIKNGYRKRIENRENVDFKYFNMILNKSINKFSDVGHLYVMDFNFYIMLRGTFDAISKNEIGGIVKNNFEMAINKKTEETYKHIYNISYGKKILKNLNFTNISNKLYDNKNLSFKEIDKDTAYIKINNFYHYNIANDKDKLINFYRKNSDKKNLVIDLTENRGGSDSYWMTNIVAPNIDKELKLYNQYALYKNGDIVNDQWVKKHGNNEYREITKDFSEVLKLSKIRKEDLKDLKYLEISKSIPYNVKPSSKKKLFKGKIYVLVSEQVQSSGEDFVEYCKNTKFATLIGTNTGGNSPAMSPVYDVLPNSGLLLMYQIDYKLNPDGTCNTEFGLPPDIVSKENEEPLDTFKRVILEKKL
>NC_022777.1|WP_023438420.1|1601929_1602112_+|hypothetical-protein
MILLLISMLSSKIFDIIFFNLLGETTGTLGSIIGFVLPYSIALEIILKKLFFEPSSKDSK
>NC_022777.1|WP_023438421.1|1602272_1604000_+|histidine-decarboxylase
MKNPMTQPTKDPNTVYPKVPGIDYDKFKLSEDKMTSKQINDALEELHNYISNQQTNFLGYQINQSFNYMKDLKEYLNVHMNNIGDPFVSGNFTVNTKFLERAVLDYFASLWNAQWPHESKGDSNTNDWKNSYWGYVVSMGSTEANFFGIWNARDYLSGKALLLDTSTHKRAKSASVNGNPQSVEPRVLNYQAKSLEDNPNMYTPIAFYSQDTHYSIIKGMRILNFTTFNEAGSGKFECPLKYPEDYPKGFSINYLDENGWPFEVPSNNDGSVFIPALKKLVEAFASKGYPIFVNFNYGTTFKGSYDNVEKAINELVPILKKYNLYEREIIFDKNNKNSDTRTGFWFHVDGALGAAYMPFLEMTTDNEDFPVFDFRLKDVHSISMSGHKWIGVPWPCGIYMSKIKYQLLPPDNPNYIGSPDSTFAGSRNAFSALILWYYIATHSYEDCKNMILDCQDTAKYTVEKLNELSKKLGINLWVEYSSKSLTIRFKEANPDIVFKYSLSGEILYVNGEKRAYSHIYIMPHVTKDLIDKFIEDLSKPGAFPEQVSHLEKDGVNFNSNSHKGIYVPQTGRGFK
>NC_022777.1|WP_023438422.1|1604123_1604705_-|TlpA-family-protein-disulfide-reductase
MKKRMKKIILLAVFVITIISLVGCSSDKKDNTSQNSKSIQSTSNAKVFPKFQGEDFEGNTVDEKVFSKHPVTVVNLWFAGCKACVDEMPDLEKMSAEFQKKNVKMLGIDIDSTDDKEEVKKLLKAKGVTYQNLMLKSDKEIDEFLSKISAFPTTFLINRKGEIVGEAIEGAINSPKRIEEINRKIDEIIGQDK
>NC_022777.1|WP_045923598.1|1604769_1605684_-|4Fe-4S-binding-protein
MQKPLDCVWSVLELDRKRNIIQAFSTFITNIHFPNFLKGVLYNGQIKRVCVPGLNCYSCPAATGACPIGSFQAVVGSSKFSFSYYITGILILFGVLLGRFICGFLCPFGWFQDLLYKIPFKKFSTKKLKLLTYLKYLMLFVVVGLLPILITNNVGMGSPFFCKYVCPQGILEGGIPLSIANKGIRSSLGALFALKSVILVMVILLSLMFYRPFCKWICPLGAFYSFFNKISLYSYDFNKDKCVNCGKCRRVCKMDVDITKSTTHNECIRCGECIKVCPTKAISTFWGYEKRNSSTKIIGKYKNI
>NC_022777.1|WP_023438424.1|1605637_1605787_-|hypothetical-protein
MIITKNKKIITPSALLVAITFIIIGVHRGEVNTVFAKAIRLCLECVGIG

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022777_1	1.3|1469821|36|NC_022777|CRISPRCasFinder	1469821-1469856	36	NZ_CP013844	Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence	19777-19812	0	1.0
NC_022777_1	1.7|1470089|36|NC_022777|CRISPRCasFinder	1470089-1470124	36	KM983334	Clostridium phage phiCTC2B, complete genome	24358-24393	0	1.0
NC_022777_1	1.7|1470089|36|NC_022777|CRISPRCasFinder	1470089-1470124	36	KM983331	Clostridium phage phiCT19406B, complete genome	24358-24393	0	1.0
NC_022777_1	1.10|1470288|35|NC_022777|CRISPRCasFinder	1470288-1470322	35	KM983334	Clostridium phage phiCTC2B, complete genome	24028-24062	0	1.0
NC_022777_1	1.10|1470288|35|NC_022777|CRISPRCasFinder	1470288-1470322	35	KM983331	Clostridium phage phiCT19406B, complete genome	24028-24062	0	1.0
NC_022777_1	1.25|1469821|37|NC_022777|PILER-CR,CRT	1469821-1469857	37	NZ_CP013844	Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence	19777-19813	0	1.0
NC_022777_1	1.29|1470089|37|NC_022777|PILER-CR,CRT	1470089-1470125	37	KM983334	Clostridium phage phiCTC2B, complete genome	24358-24394	0	1.0
NC_022777_1	1.29|1470089|37|NC_022777|PILER-CR,CRT	1470089-1470125	37	KM983331	Clostridium phage phiCT19406B, complete genome	24358-24394	0	1.0
NC_022777_1	1.32|1470288|36|NC_022777|PILER-CR,CRT	1470288-1470323	36	KM983334	Clostridium phage phiCTC2B, complete genome	24028-24063	0	1.0
NC_022777_1	1.32|1470288|36|NC_022777|PILER-CR,CRT	1470288-1470323	36	KM983331	Clostridium phage phiCT19406B, complete genome	24028-24063	0	1.0
NC_022777_6	6.4|1590292|35|NC_022777|CRISPRCasFinder,CRT,PILER-CR	1590292-1590326	35	NC_029006	Clostridium phage phiCT19406C, complete genome	22402-22436	0	1.0
NC_022777_6	6.5|1590357|34|NC_022777|CRISPRCasFinder,CRT,PILER-CR	1590357-1590390	34	NC_029006	Clostridium phage phiCT19406C, complete genome	26005-26038	0	1.0
NC_022777_3	3.3|1573995|34|NC_022777|CRISPRCasFinder,CRT	1573995-1574028	34	NC_010418	Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence	196160-196193	3	0.912
NC_022777_3	3.7|1573997|34|NC_022777|PILER-CR	1573997-1574030	34	NC_010418	Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence	196160-196193	3	0.912
NC_022777_7	7.9|1592877|34|NC_022777|CRISPRCasFinder,CRT	1592877-1592910	34	MN693465	Marine virus AFVG_25M405, complete genome	25756-25789	7	0.794
NC_022777_7	7.19|1592878|34|NC_022777|PILER-CR	1592878-1592911	34	MN693465	Marine virus AFVG_25M405, complete genome	25756-25789	7	0.794
NC_022777_3	3.2|1573931|34|NC_022777|CRISPRCasFinder,CRT	1573931-1573964	34	NC_028838	Clostridium phage phiCD506, complete genome	19424-19457	8	0.765
NC_022777_3	3.6|1573933|34|NC_022777|PILER-CR	1573933-1573966	34	NC_028838	Clostridium phage phiCD506, complete genome	19424-19457	8	0.765
NC_022777_7	7.1|1592358|35|NC_022777|CRISPRCasFinder,CRT	1592358-1592392	35	NZ_CP026601	Clostridiaceae bacterium 14S0207 plasmid unnamed1, complete sequence	34147-34181	8	0.771
NC_022777_7	7.9|1592877|34|NC_022777|CRISPRCasFinder,CRT	1592877-1592910	34	MN693512	Marine virus AFVG_25M128, complete genome	13186-13219	8	0.765
NC_022777_7	7.11|1592359|35|NC_022777|PILER-CR	1592359-1592393	35	NZ_CP026601	Clostridiaceae bacterium 14S0207 plasmid unnamed1, complete sequence	34147-34181	8	0.771
NC_022777_7	7.19|1592878|34|NC_022777|PILER-CR	1592878-1592911	34	MN693512	Marine virus AFVG_25M128, complete genome	13186-13219	8	0.765
NC_022777_1	1.6|1470022|36|NC_022777|CRISPRCasFinder	1470022-1470057	36	MN693340	Marine virus AFVG_25M356, complete genome	21497-21532	9	0.75
NC_022777_1	1.17|1470755|35|NC_022777|CRISPRCasFinder	1470755-1470789	35	NZ_CP027185	Acinetobacter baumannii strain AR_0052 plasmid unnamed1, complete sequence	9855-9889	9	0.743
NC_022777_1	1.17|1470755|35|NC_022777|CRISPRCasFinder	1470755-1470789	35	NZ_CP027182	Acinetobacter baumannii strain AR_0070 plasmid unnamed4, complete sequence	11218-11252	9	0.743
NC_022777_1	1.20|1470953|34|NC_022777|CRISPRCasFinder	1470953-1470986	34	NZ_CP009595	Bacillus cereus strain 3a plasmid pBFC_3, complete sequence	42873-42906	9	0.735
NC_022777_1	1.20|1470953|34|NC_022777|CRISPRCasFinder	1470953-1470986	34	NZ_CP009606	Bacillus cereus strain S2-8 plasmid pBFR_2, complete sequence	221586-221619	9	0.735
NC_022777_1	1.20|1470953|34|NC_022777|CRISPRCasFinder	1470953-1470986	34	NZ_CP053994	Bacillus cereus strain FDAARGOS_780 plasmid unnamed1, complete sequence	295357-295390	9	0.735
NC_022777_1	1.20|1470953|34|NC_022777|CRISPRCasFinder	1470953-1470986	34	NZ_CP053992	Bacillus cereus strain FDAARGOS_781 plasmid unnamed2, complete sequence	278373-278406	9	0.735
NC_022777_4	4.2|1578283|35|NC_022777|PILER-CR	1578283-1578317	35	MN694698	Marine virus AFVG_250M1036, complete genome	38249-38283	9	0.743
NC_022777_4	4.4|1578282|36|NC_022777|CRISPRCasFinder	1578282-1578317	36	MN694698	Marine virus AFVG_250M1036, complete genome	38248-38283	9	0.75
NC_022777_5	5.3|1580629|36|NC_022777|CRISPRCasFinder,CRT	1580629-1580664	36	NC_010418	Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence	25728-25763	9	0.75
NC_022777_5	5.3|1580629|36|NC_022777|CRISPRCasFinder,CRT	1580629-1580664	36	NZ_CP013684	Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence	133627-133662	9	0.75
NC_022777_7	7.4|1592553|34|NC_022777|CRISPRCasFinder,CRT	1592553-1592586	34	NC_028924	Polaribacter phage P12002L, complete genome	39311-39344	9	0.735
NC_022777_7	7.4|1592553|34|NC_022777|CRISPRCasFinder,CRT	1592553-1592586	34	NC_028763	Polaribacter phage P12002S, complete genome	39131-39164	9	0.735
NC_022777_7	7.14|1592554|34|NC_022777|PILER-CR	1592554-1592587	34	NC_028924	Polaribacter phage P12002L, complete genome	39311-39344	9	0.735
NC_022777_7	7.14|1592554|34|NC_022777|PILER-CR	1592554-1592587	34	NC_028763	Polaribacter phage P12002S, complete genome	39131-39164	9	0.735
NC_022777_1	1.7|1470089|36|NC_022777|CRISPRCasFinder	1470089-1470124	36	NC_011668	Shewanella baltica OS223 plasmid pS22302, complete sequence	48759-48794	10	0.722
NC_022777_1	1.28|1470022|37|NC_022777|PILER-CR,CRT	1470022-1470058	37	MN693340	Marine virus AFVG_25M356, complete genome	21496-21532	10	0.73
NC_022777_1	1.39|1470755|36|NC_022777|PILER-CR,CRT	1470755-1470790	36	NZ_CP027185	Acinetobacter baumannii strain AR_0052 plasmid unnamed1, complete sequence	9854-9889	10	0.722
NC_022777_1	1.39|1470755|36|NC_022777|PILER-CR,CRT	1470755-1470790	36	NZ_CP027182	Acinetobacter baumannii strain AR_0070 plasmid unnamed4, complete sequence	11217-11252	10	0.722
NC_022777_1	1.42|1470953|35|NC_022777|PILER-CR,CRT	1470953-1470987	35	NZ_CP009595	Bacillus cereus strain 3a plasmid pBFC_3, complete sequence	42873-42907	10	0.714
NC_022777_1	1.42|1470953|35|NC_022777|PILER-CR,CRT	1470953-1470987	35	NZ_CP009606	Bacillus cereus strain S2-8 plasmid pBFR_2, complete sequence	221586-221620	10	0.714
NC_022777_1	1.42|1470953|35|NC_022777|PILER-CR,CRT	1470953-1470987	35	NZ_CP053994	Bacillus cereus strain FDAARGOS_780 plasmid unnamed1, complete sequence	295357-295391	10	0.714
NC_022777_1	1.42|1470953|35|NC_022777|PILER-CR,CRT	1470953-1470987	35	NZ_CP053992	Bacillus cereus strain FDAARGOS_781 plasmid unnamed2, complete sequence	278373-278407	10	0.714
NC_022777_5	5.7|1580629|37|NC_022777|PILER-CR	1580629-1580665	37	NC_010418	Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence	25728-25764	10	0.73
NC_022777_5	5.7|1580629|37|NC_022777|PILER-CR	1580629-1580665	37	NZ_CP013684	Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence	133626-133662	10	0.73
NC_022777_7	7.4|1592553|34|NC_022777|CRISPRCasFinder,CRT	1592553-1592586	34	KC821607	Cellulophaga phage phi19:1, complete genome	55333-55366	10	0.706
NC_022777_7	7.5|1592617|35|NC_022777|CRISPRCasFinder,CRT	1592617-1592651	35	KU878088	Bacillus phage AR9, complete genome	141013-141047	10	0.714
NC_022777_7	7.5|1592617|35|NC_022777|CRISPRCasFinder,CRT	1592617-1592651	35	MF360957	Bacillus virus PBS1, complete genome	51144-51178	10	0.714
NC_022777_7	7.6|1592682|34|NC_022777|CRISPRCasFinder,CRT	1592682-1592715	34	NZ_CP009218	Rickettsiales bacterium Ac37b plasmid 1, complete sequence	21090-21123	10	0.706
NC_022777_7	7.14|1592554|34|NC_022777|PILER-CR	1592554-1592587	34	KC821607	Cellulophaga phage phi19:1, complete genome	55333-55366	10	0.706
NC_022777_7	7.15|1592618|35|NC_022777|PILER-CR	1592618-1592652	35	KU878088	Bacillus phage AR9, complete genome	141013-141047	10	0.714
NC_022777_7	7.15|1592618|35|NC_022777|PILER-CR	1592618-1592652	35	MF360957	Bacillus virus PBS1, complete genome	51144-51178	10	0.714
NC_022777_7	7.16|1592683|34|NC_022777|PILER-CR	1592683-1592716	34	NZ_CP009218	Rickettsiales bacterium Ac37b plasmid 1, complete sequence	21090-21123	10	0.706
NC_022777_1	1.2|1469756|34|NC_022777|CRISPRCasFinder	1469756-1469789	34	NC_017804	Borreliella garinii BgVir plasmid lp54, complete sequence	971-1004	11	0.676
NC_022777_1	1.2|1469756|34|NC_022777|CRISPRCasFinder	1469756-1469789	34	NC_006129	Borreliella bavariensis PBi plasmid lp54, complete sequence	55012-55045	11	0.676
NC_022777_1	1.29|1470089|37|NC_022777|PILER-CR,CRT	1470089-1470125	37	NC_011668	Shewanella baltica OS223 plasmid pS22302, complete sequence	48758-48794	11	0.703
NC_022777_7	7.4|1592553|34|NC_022777|CRISPRCasFinder,CRT	1592553-1592586	34	MN693186	Marine virus AFVG_25M505, complete genome	15029-15062	11	0.676
NC_022777_7	7.14|1592554|34|NC_022777|PILER-CR	1592554-1592587	34	MN693186	Marine virus AFVG_25M505, complete genome	15029-15062	11	0.676

1. spacer 1.3|1469821|36|NC_022777|CRISPRCasFinder matches to NZ_CP013844 (Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence) position: , mismatch: 0, identity: 1.0

atataacttgtaaaaaatgtgaaaattctcttacat	CRISPR spacer
atataacttgtaaaaaatgtgaaaattctcttacat	Protospacer
************************************

2. spacer 1.7|1470089|36|NC_022777|CRISPRCasFinder matches to KM983334 (Clostridium phage phiCTC2B, complete genome) position: , mismatch: 0, identity: 1.0

ggatacgaacaacaagtattaaatatatctaaatca	CRISPR spacer
ggatacgaacaacaagtattaaatatatctaaatca	Protospacer
************************************

3. spacer 1.7|1470089|36|NC_022777|CRISPRCasFinder matches to KM983331 (Clostridium phage phiCT19406B, complete genome) position: , mismatch: 0, identity: 1.0

ggatacgaacaacaagtattaaatatatctaaatca	CRISPR spacer
ggatacgaacaacaagtattaaatatatctaaatca	Protospacer
************************************

4. spacer 1.10|1470288|35|NC_022777|CRISPRCasFinder matches to KM983334 (Clostridium phage phiCTC2B, complete genome) position: , mismatch: 0, identity: 1.0

tacttattgtaggtgctttttcttattatctaaga	CRISPR spacer
tacttattgtaggtgctttttcttattatctaaga	Protospacer
***********************************

5. spacer 1.10|1470288|35|NC_022777|CRISPRCasFinder matches to KM983331 (Clostridium phage phiCT19406B, complete genome) position: , mismatch: 0, identity: 1.0

tacttattgtaggtgctttttcttattatctaaga	CRISPR spacer
tacttattgtaggtgctttttcttattatctaaga	Protospacer
***********************************

6. spacer 1.25|1469821|37|NC_022777|PILER-CR,CRT matches to NZ_CP013844 (Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence) position: , mismatch: 0, identity: 1.0

atataacttgtaaaaaatgtgaaaattctcttacata	CRISPR spacer
atataacttgtaaaaaatgtgaaaattctcttacata	Protospacer
*************************************

7. spacer 1.29|1470089|37|NC_022777|PILER-CR,CRT matches to KM983334 (Clostridium phage phiCTC2B, complete genome) position: , mismatch: 0, identity: 1.0

ggatacgaacaacaagtattaaatatatctaaatcaa	CRISPR spacer
ggatacgaacaacaagtattaaatatatctaaatcaa	Protospacer
*************************************

8. spacer 1.29|1470089|37|NC_022777|PILER-CR,CRT matches to KM983331 (Clostridium phage phiCT19406B, complete genome) position: , mismatch: 0, identity: 1.0

ggatacgaacaacaagtattaaatatatctaaatcaa	CRISPR spacer
ggatacgaacaacaagtattaaatatatctaaatcaa	Protospacer
*************************************

9. spacer 1.32|1470288|36|NC_022777|PILER-CR,CRT matches to KM983334 (Clostridium phage phiCTC2B, complete genome) position: , mismatch: 0, identity: 1.0

tacttattgtaggtgctttttcttattatctaagaa	CRISPR spacer
tacttattgtaggtgctttttcttattatctaagaa	Protospacer
************************************

10. spacer 1.32|1470288|36|NC_022777|PILER-CR,CRT matches to KM983331 (Clostridium phage phiCT19406B, complete genome) position: , mismatch: 0, identity: 1.0

tacttattgtaggtgctttttcttattatctaagaa	CRISPR spacer
tacttattgtaggtgctttttcttattatctaagaa	Protospacer
************************************

11. spacer 6.4|1590292|35|NC_022777|CRISPRCasFinder,CRT,PILER-CR matches to NC_029006 (Clostridium phage phiCT19406C, complete genome) position: , mismatch: 0, identity: 1.0

aaaagccaatcaaaatctattttatatttagattt	CRISPR spacer
aaaagccaatcaaaatctattttatatttagattt	Protospacer
***********************************

12. spacer 6.5|1590357|34|NC_022777|CRISPRCasFinder,CRT,PILER-CR matches to NC_029006 (Clostridium phage phiCT19406C, complete genome) position: , mismatch: 0, identity: 1.0

ggcagagaaatcgcaagaataacagctaaaccaa	CRISPR spacer
ggcagagaaatcgcaagaataacagctaaaccaa	Protospacer
**********************************

13. spacer 3.3|1573995|34|NC_022777|CRISPRCasFinder,CRT matches to NC_010418 (Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence) position: , mismatch: 3, identity: 0.912

gttttgcagaggttcgagaaaaacttaaatatta	CRISPR spacer
ggtttgcagaggttagagaaaaactaaaatatta	Protospacer
* ************ ********** ********

14. spacer 3.7|1573997|34|NC_022777|PILER-CR matches to NC_010418 (Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence) position: , mismatch: 3, identity: 0.912

gttttgcagaggttcgagaaaaacttaaatatta	CRISPR spacer
ggtttgcagaggttagagaaaaactaaaatatta	Protospacer
* ************ ********** ********

15. spacer 7.9|1592877|34|NC_022777|CRISPRCasFinder,CRT matches to MN693465 (Marine virus AFVG_25M405, complete genome) position: , mismatch: 7, identity: 0.794

ctaatagtag-gataataattcaattcatttaaca	CRISPR spacer
-tacaggtaatgataataattcaaataatttaaca	Protospacer
 **  .***. ************* * ********

16. spacer 7.19|1592878|34|NC_022777|PILER-CR matches to MN693465 (Marine virus AFVG_25M405, complete genome) position: , mismatch: 7, identity: 0.794

ctaatagtag-gataataattcaattcatttaaca	CRISPR spacer
-tacaggtaatgataataattcaaataatttaaca	Protospacer
 **  .***. ************* * ********

17. spacer 3.2|1573931|34|NC_022777|CRISPRCasFinder,CRT matches to NC_028838 (Clostridium phage phiCD506, complete genome) position: , mismatch: 8, identity: 0.765

gcttaggctaggagctacctctttttttattttt	CRISPR spacer
taatttgctagttgctacctctttttttatttta	Protospacer
   *  *****  ******************** 

18. spacer 3.6|1573933|34|NC_022777|PILER-CR matches to NC_028838 (Clostridium phage phiCD506, complete genome) position: , mismatch: 8, identity: 0.765

gcttaggctaggagctacctctttttttattttt	CRISPR spacer
taatttgctagttgctacctctttttttatttta	Protospacer
   *  *****  ******************** 

19. spacer 7.1|1592358|35|NC_022777|CRISPRCasFinder,CRT matches to NZ_CP026601 (Clostridiaceae bacterium 14S0207 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.771

gtgctgcacttctagaacttaaattacattccttt	CRISPR spacer
gtgctgcacttcttgaacttaatttatttttaatc	Protospacer
************* ******** ***. **.  *.

20. spacer 7.9|1592877|34|NC_022777|CRISPRCasFinder,CRT matches to MN693512 (Marine virus AFVG_25M128, complete genome) position: , mismatch: 8, identity: 0.765

ctaatagtag-gataataattcaattcatttaaca	CRISPR spacer
-tacaggcaatgataataattcaaataatttaaca	Protospacer
 **  .*.*. ************* * ********

21. spacer 7.11|1592359|35|NC_022777|PILER-CR matches to NZ_CP026601 (Clostridiaceae bacterium 14S0207 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.771

gtgctgcacttctagaacttaaattacattccttt	CRISPR spacer
gtgctgcacttcttgaacttaatttatttttaatc	Protospacer
************* ******** ***. **.  *.

22. spacer 7.19|1592878|34|NC_022777|PILER-CR matches to MN693512 (Marine virus AFVG_25M128, complete genome) position: , mismatch: 8, identity: 0.765

ctaatagtag-gataataattcaattcatttaaca	CRISPR spacer
-tacaggcaatgataataattcaaataatttaaca	Protospacer
 **  .*.*. ************* * ********

23. spacer 1.6|1470022|36|NC_022777|CRISPRCasFinder matches to MN693340 (Marine virus AFVG_25M356, complete genome) position: , mismatch: 9, identity: 0.75

taagcttgattttctgaaactttttcttctacaaat	CRISPR spacer
ttaaaatgatcttctgaaacttttttttctactata	Protospacer
* *.  ****.**************.****** *  

24. spacer 1.17|1470755|35|NC_022777|CRISPRCasFinder matches to NZ_CP027185 (Acinetobacter baumannii strain AR_0052 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.743

agttgcaaagatagcttcaaaagaagatataaaga	CRISPR spacer
gagggaaaagatggcttcaaaagatgatataaatt	Protospacer
..  * ******.*********** ********  

25. spacer 1.17|1470755|35|NC_022777|CRISPRCasFinder matches to NZ_CP027182 (Acinetobacter baumannii strain AR_0070 plasmid unnamed4, complete sequence) position: , mismatch: 9, identity: 0.743

agttgcaaagatagcttcaaaagaagatataaaga	CRISPR spacer
gagggaaaagatggcttcaaaagatgatataaatt	Protospacer
..  * ******.*********** ********  

26. spacer 1.20|1470953|34|NC_022777|CRISPRCasFinder matches to NZ_CP009595 (Bacillus cereus strain 3a plasmid pBFC_3, complete sequence) position: , mismatch: 9, identity: 0.735

gttgagaaacgatataaaaaatcaatagtagcca	CRISPR spacer
attgagaaattatataaaaaatcaatgttgctta	Protospacer
.********. ***************. *. ..*

27. spacer 1.20|1470953|34|NC_022777|CRISPRCasFinder matches to NZ_CP009606 (Bacillus cereus strain S2-8 plasmid pBFR_2, complete sequence) position: , mismatch: 9, identity: 0.735

gttgagaaacgatataaaaaatcaatagtagcca	CRISPR spacer
attgagaaattatataaaaaatcaatgttgctta	Protospacer
.********. ***************. *. ..*

28. spacer 1.20|1470953|34|NC_022777|CRISPRCasFinder matches to NZ_CP053994 (Bacillus cereus strain FDAARGOS_780 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

gttgagaaacgatataaaaaatcaatagtagcca	CRISPR spacer
attgagaaattatataaaaaatcaatgttgctta	Protospacer
.********. ***************. *. ..*

29. spacer 1.20|1470953|34|NC_022777|CRISPRCasFinder matches to NZ_CP053992 (Bacillus cereus strain FDAARGOS_781 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.735

gttgagaaacgatataaaaaatcaatagtagcca	CRISPR spacer
attgagaaattatataaaaaatcaatgttgctta	Protospacer
.********. ***************. *. ..*

30. spacer 4.2|1578283|35|NC_022777|PILER-CR matches to MN694698 (Marine virus AFVG_250M1036, complete genome) position: , mismatch: 9, identity: 0.743

cttatgcgtagtttctatattccagttcttttctt	CRISPR spacer
taattccgtagtttctatattctaggtcttttgtc	Protospacer
.   * ****************.** ****** *.

31. spacer 4.4|1578282|36|NC_022777|CRISPRCasFinder matches to MN694698 (Marine virus AFVG_250M1036, complete genome) position: , mismatch: 9, identity: 0.75

acttatgcgtagtttctatattccagttcttttctt	CRISPR spacer
ataattccgtagtttctatattctaggtcttttgtc	Protospacer
*.   * ****************.** ****** *.

32. spacer 5.3|1580629|36|NC_022777|CRISPRCasFinder,CRT matches to NC_010418 (Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence) position: , mismatch: 9, identity: 0.75

tattaattttatattaaacaaaaatcataaattcaa	CRISPR spacer
tcatcatttaaaattaaacaaaaatcataaaatagg	Protospacer
*  * **** * ******************* * ..

33. spacer 5.3|1580629|36|NC_022777|CRISPRCasFinder,CRT matches to NZ_CP013684 (Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence) position: , mismatch: 9, identity: 0.75

tattaattttatattaaacaaaaatcataaattcaa	CRISPR spacer
tcatcatttaaaattaaacaaaaatcataaaatagg	Protospacer
*  * **** * ******************* * ..

34. spacer 7.4|1592553|34|NC_022777|CRISPRCasFinder,CRT matches to NC_028924 (Polaribacter phage P12002L, complete genome) position: , mismatch: 9, identity: 0.735

tattagaaatacttagatttttaggtacagggac	CRISPR spacer
aattagaattacttagatatttaggaagtaaaac	Protospacer
 ******* ********* ****** *  ...**

35. spacer 7.4|1592553|34|NC_022777|CRISPRCasFinder,CRT matches to NC_028763 (Polaribacter phage P12002S, complete genome) position: , mismatch: 9, identity: 0.735

tattagaaatacttagatttttaggtacagggac	CRISPR spacer
aattagaattacttagatatttaggaagtaaaac	Protospacer
 ******* ********* ****** *  ...**

36. spacer 7.14|1592554|34|NC_022777|PILER-CR matches to NC_028924 (Polaribacter phage P12002L, complete genome) position: , mismatch: 9, identity: 0.735

tattagaaatacttagatttttaggtacagggac	CRISPR spacer
aattagaattacttagatatttaggaagtaaaac	Protospacer
 ******* ********* ****** *  ...**

37. spacer 7.14|1592554|34|NC_022777|PILER-CR matches to NC_028763 (Polaribacter phage P12002S, complete genome) position: , mismatch: 9, identity: 0.735

tattagaaatacttagatttttaggtacagggac	CRISPR spacer
aattagaattacttagatatttaggaagtaaaac	Protospacer
 ******* ********* ****** *  ...**

38. spacer 1.7|1470089|36|NC_022777|CRISPRCasFinder matches to NC_011668 (Shewanella baltica OS223 plasmid pS22302, complete sequence) position: , mismatch: 10, identity: 0.722

ggatacgaacaacaagtattaaatatatctaaatca	CRISPR spacer
agtgcagaacaacaaggattaaatatatcgaaagag	Protospacer
.*    ********** ************ ***  .

39. spacer 1.28|1470022|37|NC_022777|PILER-CR,CRT matches to MN693340 (Marine virus AFVG_25M356, complete genome) position: , mismatch: 10, identity: 0.73

taagcttgattttctgaaactttttcttctacaaata	CRISPR spacer
ttaaaatgatcttctgaaacttttttttctactatat	Protospacer
* *.  ****.**************.****** *   

40. spacer 1.39|1470755|36|NC_022777|PILER-CR,CRT matches to NZ_CP027185 (Acinetobacter baumannii strain AR_0052 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.722

agttgcaaagatagcttcaaaagaagatataaagat	CRISPR spacer
gagggaaaagatggcttcaaaagatgatataaatta	Protospacer
..  * ******.*********** ********   

41. spacer 1.39|1470755|36|NC_022777|PILER-CR,CRT matches to NZ_CP027182 (Acinetobacter baumannii strain AR_0070 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.722

agttgcaaagatagcttcaaaagaagatataaagat	CRISPR spacer
gagggaaaagatggcttcaaaagatgatataaatta	Protospacer
..  * ******.*********** ********   

42. spacer 1.42|1470953|35|NC_022777|PILER-CR,CRT matches to NZ_CP009595 (Bacillus cereus strain 3a plasmid pBFC_3, complete sequence) position: , mismatch: 10, identity: 0.714

gttgagaaacgatataaaaaatcaatagtagccaa	CRISPR spacer
attgagaaattatataaaaaatcaatgttgcttat	Protospacer
.********. ***************. *. ..* 

43. spacer 1.42|1470953|35|NC_022777|PILER-CR,CRT matches to NZ_CP009606 (Bacillus cereus strain S2-8 plasmid pBFR_2, complete sequence) position: , mismatch: 10, identity: 0.714

gttgagaaacgatataaaaaatcaatagtagccaa	CRISPR spacer
attgagaaattatataaaaaatcaatgttgcttat	Protospacer
.********. ***************. *. ..* 

44. spacer 1.42|1470953|35|NC_022777|PILER-CR,CRT matches to NZ_CP053994 (Bacillus cereus strain FDAARGOS_780 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.714

gttgagaaacgatataaaaaatcaatagtagccaa	CRISPR spacer
attgagaaattatataaaaaatcaatgttgcttat	Protospacer
.********. ***************. *. ..* 

45. spacer 1.42|1470953|35|NC_022777|PILER-CR,CRT matches to NZ_CP053992 (Bacillus cereus strain FDAARGOS_781 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.714

gttgagaaacgatataaaaaatcaatagtagccaa	CRISPR spacer
attgagaaattatataaaaaatcaatgttgcttat	Protospacer
.********. ***************. *. ..* 

46. spacer 5.7|1580629|37|NC_022777|PILER-CR matches to NC_010418 (Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence) position: , mismatch: 10, identity: 0.73

tattaattttatattaaacaaaaatcataaattcaaa	CRISPR spacer
tcatcatttaaaattaaacaaaaatcataaaataggc	Protospacer
*  * **** * ******************* * .. 

47. spacer 5.7|1580629|37|NC_022777|PILER-CR matches to NZ_CP013684 (Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence) position: , mismatch: 10, identity: 0.73

tattaattttatattaaacaaaaatcataaattcaaa	CRISPR spacer
tcatcatttaaaattaaacaaaaatcataaaataggc	Protospacer
*  * **** * ******************* * .. 

48. spacer 7.4|1592553|34|NC_022777|CRISPRCasFinder,CRT matches to KC821607 (Cellulophaga phage phi19:1, complete genome) position: , mismatch: 10, identity: 0.706

tattagaaatacttagatttttaggtacagggac	CRISPR spacer
aattagaaatacttagatatttaggaatcaaaga	Protospacer
 ***************** ****** *. .... 

49. spacer 7.5|1592617|35|NC_022777|CRISPRCasFinder,CRT matches to KU878088 (Bacillus phage AR9, complete genome) position: , mismatch: 10, identity: 0.714

aggctatggattattaaagagtttaatttagataa	CRISPR spacer
ttaatgtggattagtaaagaatttaatttagtaga	Protospacer
  . *.******* ******.**********  .*

50. spacer 7.5|1592617|35|NC_022777|CRISPRCasFinder,CRT matches to MF360957 (Bacillus virus PBS1, complete genome) position: , mismatch: 10, identity: 0.714

aggctatggattattaaagagtttaatttagataa	CRISPR spacer
ttaatgtggattagtaaagaatttaatttagtaga	Protospacer
  . *.******* ******.**********  .*

51. spacer 7.6|1592682|34|NC_022777|CRISPRCasFinder,CRT matches to NZ_CP009218 (Rickettsiales bacterium Ac37b plasmid 1, complete sequence) position: , mismatch: 10, identity: 0.706

ttttatcatctagtcctttaaaaattaaagttag	CRISPR spacer
tattctcatctaatcctttaaaaattccatcccc	Protospacer
* ** *******.*************  * ..  

52. spacer 7.14|1592554|34|NC_022777|PILER-CR matches to KC821607 (Cellulophaga phage phi19:1, complete genome) position: , mismatch: 10, identity: 0.706

tattagaaatacttagatttttaggtacagggac	CRISPR spacer
aattagaaatacttagatatttaggaatcaaaga	Protospacer
 ***************** ****** *. .... 

53. spacer 7.15|1592618|35|NC_022777|PILER-CR matches to KU878088 (Bacillus phage AR9, complete genome) position: , mismatch: 10, identity: 0.714

aggctatggattattaaagagtttaatttagataa	CRISPR spacer
ttaatgtggattagtaaagaatttaatttagtaga	Protospacer
  . *.******* ******.**********  .*

54. spacer 7.15|1592618|35|NC_022777|PILER-CR matches to MF360957 (Bacillus virus PBS1, complete genome) position: , mismatch: 10, identity: 0.714

aggctatggattattaaagagtttaatttagataa	CRISPR spacer
ttaatgtggattagtaaagaatttaatttagtaga	Protospacer
  . *.******* ******.**********  .*

55. spacer 7.16|1592683|34|NC_022777|PILER-CR matches to NZ_CP009218 (Rickettsiales bacterium Ac37b plasmid 1, complete sequence) position: , mismatch: 10, identity: 0.706

ttttatcatctagtcctttaaaaattaaagttag	CRISPR spacer
tattctcatctaatcctttaaaaattccatcccc	Protospacer
* ** *******.*************  * ..  

56. spacer 1.2|1469756|34|NC_022777|CRISPRCasFinder matches to NC_017804 (Borreliella garinii BgVir plasmid lp54, complete sequence) position: , mismatch: 11, identity: 0.676

tttgctttatcctctactaatttacggcgtgctt	CRISPR spacer
tttgctttatcctctaatcatttataaatctgta	Protospacer
**************** * *****...  .  * 

57. spacer 1.2|1469756|34|NC_022777|CRISPRCasFinder matches to NC_006129 (Borreliella bavariensis PBi plasmid lp54, complete sequence) position: , mismatch: 11, identity: 0.676

tttgctttatcctctactaatttacggcgtgctt	CRISPR spacer
tttgctttatcctctaatcatttataaatctata	Protospacer
**************** * *****...  .  * 

58. spacer 1.29|1470089|37|NC_022777|PILER-CR,CRT matches to NC_011668 (Shewanella baltica OS223 plasmid pS22302, complete sequence) position: , mismatch: 11, identity: 0.703

ggatacgaacaacaagtattaaatatatctaaatcaa	CRISPR spacer
agtgcagaacaacaaggattaaatatatcgaaagagg	Protospacer
.*    ********** ************ ***  ..

59. spacer 7.4|1592553|34|NC_022777|CRISPRCasFinder,CRT matches to MN693186 (Marine virus AFVG_25M505, complete genome) position: , mismatch: 11, identity: 0.676

tattagaaatacttagatttttaggtacagggac	CRISPR spacer
cagatcgaatacttagatttttacgaacaggtca	Protospacer
.*    .**************** * *****   

60. spacer 7.14|1592554|34|NC_022777|PILER-CR matches to MN693186 (Marine virus AFVG_25M505, complete genome) position: , mismatch: 11, identity: 0.676

tattagaaatacttagatttttaggtacagggac	CRISPR spacer
cagatcgaatacttagatttttacgaacaggtca	Protospacer
.*    .**************** * *****   

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	459142 : 532262	57	Planktothrix_phage(50.0%)	protease,transposase	NA
DBSCAN-SWA_2	1119025 : 1169373	62	Clostridium_phage(92.59%)	holin,portal,tail,capsid	NA
DBSCAN-SWA_3	1652559 : 1659595	8	uncultured_Mediterranean_phage(50.0%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_022777|459142:532262|DBSCAN-SWA
TGTGGACCAAGCGAAATCCTATATATTTAGGATAGTGAGGGATAGCAAAAATGATGAAAATTATGTTGTAAGTAATATAAAAGCTGATAATCCAGAAGATTTAAATAGAATTTTAAAAGCAGAAATGGAGAATTATCCAAATGCTATAGAATTTAAAGTTAAAACTGAAAAGATACAAGAAACATTTAATAGTTTAGAATCAGCATATGATGATTATTTTAAAGAAAATAGAACAAAATATCCTAATATTAAGTATGGGATAAAATTAAAAAGTCCAGATGGTAAATATAATCCAACAGATGAATATGTAGATGTAATATTTGAAGCTAAATATGTAGTTTATGGAACAGAAGAAGAAATTCCAGCAGAAAAACTTAGGAGCTATGAAGAAGAAGCAGAAAAAATAGCGAAGGACTTTGTAAATAAAGAAATAGGAGGTAAAAATTTATCTGATGCAGAAAAGGCTTTAAAGATAAATGATTATTTAGTAAAAAGAGCAGCATACCATCATGAAGGTGTAAATACATACTATGTAGAAGACCATATCGCATATGGAGTTTTAAGTGATCGAAAAAAAGGTGTTTGTGAATCCTATGCAAAAGCATTCCAATTACTTGCAGAGAAATCAGGATTAACAAGTATTTATGTTACAGGACAAGGAAAGAACCCTAATAAAGATAAAGGAGAAGCTCATGCATGGAATATGGTGAAAATAGATGGTCAGTGGTATAGTATAGATACTACCTGGAACGATATTGGGGAAGGAAGTAGATATGATTACTTCTTAAAGTCAGATGATGATATGAAAGCTACTCACACAAGATCAACAGATTTTAATTATCCTACAGGAAATGGAACAAAAGATTTTGTTGCAGAATTAAAATTAAAATAAAAGTAAGCAAGCTCAGTTTCTTTCGCAAGGATTCCAAGAATCATGAACAAATTATAAACAAAATATTAATTAGTAAAGCTTAAAAGGATAGTCTGTTTTGACTATCCTTTTTTAGATTTCATTATAAAGTAAAAAAACTTTTTGTAAAAAATAAATATTTAGACTAAAGATTTTCTAATAAATACGATAATTATAGTAGAAGAGATATTAAATGATTCAATTTCAGATATACCTAATGAAGTTTTATATGATTATTATAAAATAAAGAAAAAAGGACAGTCCGTTAAGACCATCCTTTCGTGAGTTTTATTATAATGACATTTAAAGGCTAAGAAGAATTTAAAATATCCATATATAATAAATCACTCATTACCATTAATTCTAAGTTAATGGTATAACATAGGAAATCAATCCATGAGGGGGATGAATTCCTACTAATTATATTATAAATGAAATATCCATAAAAGTCATTATAAAATTGAAGGAATTTGAGGAATAGTAATACATATATTATTTAATTAGGTTTATATGGAAGCAAGATGAAAGTAAAAAATATATTCATTGAATGCAAAAATTGCTATATCAAAATAAAATTTTGATATAGCAATAGCAGAGGATTAGCAGATAGTGGTAAACATGAAATTCAATCCACTGTATACAATTTATATAAAGTAAATTCTAATAATTACGATATATATAATAATTTATAATTAAAATTTCAATCATATTGTACGTTCATTAAAATCCGTATAAAACCATATATTTAGTTTATATTATCGATAGAACGCCTTATGCGGTGAAAGTCGCACGTAGGGTGTGGACCAAGCGAAATCCTATGTATTTAGGATAGTAAGGGATAGCAAAGAAACAGAAGAGAAAGAAAAACAAGAACAAGCTGAAAAGGAAAGACAAAAAAAATTAGCCGATGCTCAATCAGTGCAAAAAGCAAAGGATAATTTAAATTTAACTAATTTAAATAATGTAAGTTCTAACATTAATTTACCAAAGGATATTGACGGAGTTTCAATTACTTGGAAATCTAATAACACTAGTGTACTTGATGAAAAAGGAAATGTTACAAGACCATCAGCAACAAAGGGAGATACTTTAGTAACTCTAACAGCTACATTAACAAAGGATGAAGCTAAAGATACTAAAGATTTTATAGTAACTGTTAAAGCTAAAGATTTTACAGATGAAGAACTTGTAGATATGGCTCTTGGCAATTTACAACCGGAAGGAAAACTTGACTCTGTAGTAGATAATTTAAAGTTACCAACTAAAGATGATAAAAATGCTGTGGATATAACTTGGAATTCAAGTAATGAATCAGTAGTTTCAAATGCCGGTGTAGTTACAAGAACGGATAAAGACGAAAATATTACATTAATAGCTACATTAAAAAAAGGCTCTATTACAAAAACTAAAGAATTTAATATAGTAGTTAAAGCAAAAGAAAAAGATACACAAGAAGCTTTAAAACTAATTGCAAATTCCTTAGAAATAAGCAATAAAGGCAGTATAGAAAAAGACATTAATTTACCAACTTCTTTAGATGGAGCAACTGTAATATGGAAGTCAAATAATGAAGCTGTAATAAGTAATACAGGAAAAGTAACAAGACCTAAAATAGGGAAATCAGATGAAAAAGTAACATTAACTGCTACTATAACTAAAGATGGTAAAAATGAAACTAAAGATTTTACAGTAACTGTTAAAGCTGAAAAACAATTAGTAGCTAATAATAAACAAGAATTTAATGAAATTTTAAAACAAGCAATAATAGACTGTGAACCTACGGTAGACATCAGCTTACCAAATTTTGACACTAATAATAATGTATATAAATTTGATGATTATCAAAATCTACTCATTGAAATTGGAGAAATGGATTTTGGAAAGCCAGGAGTAGAAGGTAATTATAAAAATGATGGAAAAGGTTGGATAATGACAGTAGAATTTAAATATAGAAAAGATGCCGCTGAAATTAAAAGACAAAAAGAAGCTACAATAAAGAAAGCTAAAGAGGTTGTAAAAGATGTTATAAAACCAGGTATGAAGCATTATGAAAAAGAATTAGCATTACATGATTATATAGTAAAAACTGCTGATTATAATGTAGAAAACTATAATAAAGGTAAGACTACTTTAGAAGATCATACTGCTTATGGTGTATTAGTAGACCGTATTGGTGTTTGCGAAAGCTATGCTAAAGCTATGAATTTACTTTTAAAAGAAGTTGGAATTGATTGTAAGTATGTTACAGGGTTCTCAAAGCATAATGGAGTTAAAGGCGGAGGACATGCATGGAACATGGTTCAGTTGGATGGAGAATGGTATAACTTAGATGCTACATGGAATGATCCAGTTTCTGATAGAAATGGTGCTGAAAGTGTAAACAAAGACAATACTTCACCAGCAACAGTTAATCATACTTATTTTAATCTTCCAGATGATATTTTTAACAATGATCACATAAGAGGAGATTTTGAAGAAAAGAATTATCCAAAATGTACAGCTACAAAATACTCATACCACAATATGGATGTAGATGAATACACAGCTGATGGAAAATTAATTGAAAAAGTTACAACTAAAGATGAATTAGATGCAAAAATATTAGAAGCTATAAAAAATAAAGAAAAAACTTTAAGTTTAAGAATTAAAGGCTTTAAAATGACCCAAAAGGAGTTAAGTGATGAATTTAAAGCAGTTGCAGAAAAGAATAGAGTGGGTGGATGTAGCTGGAGTACAAGTGCACCAGATGATTACCATGTTAACTATACTATAAAGTGGTAATTTGAAATTTATTTAATACTAATTTAATCAAATAATCAATGTAGAATTGCTATATCGAAATTTTATTTTGGTATAGCAATTTTTTAAAAAATTATATAAAGTCATATTTAACAATTACGATATATATAGTAATTTATATTAAAAATACTTATAAAATAAAATCTTATATTAGTATCTATTGTCGATGGAACGCCCTATGCGGTGAAAATCGCACGTAGGGTGTGGACCAAACGAAATCCTATGTATTTAGGATAGTGAGGGATAGCAGTGAATCAGCAGACAGTGGTGAGCATAAAATAGAATCCACAAAAATAGGAATATTAGAAGGAACAACACTTAAAGATATTCCAACGGGTACAACTATAGAACAATTAAAAAAAGCATTAACAGTATCAAAAGGAGCTAATATTCATTTTGTAAAAAAGAATGAACAAAATACTCCAGAAATAAAAGACCTAACAGAATTAGTAACTGATGAAATGGAAATAGTAGTGGAATCAGGAACACAAACAGTATATACAATAGAAATAATTTAATAGAATGATCGGAAACATTTCAAACTTAATTCACATCAAAACAATTTAAATTCATAAAATATCCAGGACACATCACTGGCTGAAAAATTAAATACATTTCATAAAAGACCAATCCTTTTGGGGTTGGTCTTTTTTTACTGCAAGTGCTCTAGTATGATGAAAACTTGTATGTAAAAAGGATATTTATATTGTAGAACTATAAATAGTTAAGTTTATTACCTAATATTCATTATTGACAAAATCATGAAATTAAAGTAATATGTATATACAACAGTTTAATACCATATAAATATAATATTTTAAGAGGAAATTTTGAACTATATACTTATTTGGGCACTTTGTATATAGGGAGTTAGTAGTGCAACCGACCTTGATTAATCAGGGTCGGTTTTTATTTTTAAATAAAGCAAGAAATAACTAGGAGGGGGTATATTGAAAACCTTTGACAAAATAATTAAAGGCAGAAAAAATATCATAATTATTTTGACATTTTTATTTCAGATATTATTATGCTCAAAAACTGTATTAGCAGCAAATGTAGATGTTATAGATAATGTTAAAATAACTAATGAAAAGGGGGTAGTGCAAGGTGGTTATAGACCAGGTGATAGAATAAGAATTGATGTAGATTGGTCTATTAAATCAGAAACAAAAGCTGGAGATACCTTTAGTTTAAAGATACCCAAAGAATTACGAGGGTTTAATGGTACAATTCAGTTAAGGGATAAGGAAGGACGTAATTTTGGTACAGGAGTAGGAAAAGGTGATGTAATTACTTTTACATTTTCTGATATTGTTGAGAAATTGGAAAACATATCTGGGTTCTTCTATATTCAATCAGAAATCAAGTATATAGAGAGGCAAGGTGAAATAGAAGTTCCATTGGTGTTTGAAGTAAATGGTAAGGCTATTAAAAACTCAATTATTGTTGATACAGGAAGTACAAATTCTGGAGGAAGTCCTAGTAAAATAACAGAAATGTTTCAAAAGTGGGGCAGAATTAATGAGAATGATGATAATATAATAGACTGGGTTTTACGAGTAAATTATAAAGGTGAACAACTATATAACATCACCATAACTGATATGATTAGTAAGGGACATGAATTTGTTGATGGTAGCTTGGAATTATATAAGGGATATACTAATCATCGAACTGGAAATATAGATAATCAAACTAAAGTTCCATTAAAATATCCTGTTAATTTTTCATCTTCGCTCTCTGGATTTAAATTAAAGCTTTATAATGAAAGTGAAACATATACATTGTATTATCAAACAAAAATTGTAGATAAGAGTATATCTGACTTTAGAAATAAAGCAACCTTAGAAGCATATAATAAAAAGCCAATTATTAAAGAAATAATGGTAAAAGATTTTTCCAGTGGTGGAGGTGCTTCAGGTGATTTAAAGAAATATAAAGGGAAGTTAAAGCTTATTAAGCAAGATAAAACCACTGGAGAATTATTAGAAGGTGCTGTGTTTGAATTAATTAATGATGAAAATAAAGTAGTAACAACACTTACAACAAATAGGAAGGGTGAGGCTATTACTAATGAGGTTTTAGGTGGAATATATACACTTAAAGAAATAAAGGCACCAAAAGGGTATAAAATAGAGTTAGAGTCTGAAGAAATTACTTTAAATTTTAAAGAAAATAAAGAGATTAAAAAGATTGTAACAAACAAAAAAGTAACACTATGGACTCCAATAGAGCCTATTAAAGGAAGCATAAAAATAACTAAGGTTGATAAAGATAATTTAGATAAAGTATTAGAAGGAGCAGAATTTACACTTAAGGGTATATCAGAACACAATAAAAACATTAAACTAATAGGAATCACTGATAAAAATGGATTATTAGAATTTAAAGATATACCATATGGAAAATATACGCTTAAAGAAATAAAGGCACCAGAAGGATATAGAATATATGAAGGAGAACAAGAAATAATAATAAAATCACAAGGTAAAGTAGTAGAAGTTAAAGTAGAAAATAGGAAATCAAAAACAAGTTCAGGTTCAGGCTCAAGAAACCCAGATCCAGAAAAACCGAATTCAGAAAAGCCTTATCCAGAAAAACCAGAAACAAAAGATCCACCAATAGATAAAGGCGATGAATTACCTCCTCAGGAGTTAGATGTTATTAAAGATAAATTAAAAGATAAATTGGTAGATAAAGATAAAAAACCATCTGTAAAAGTGAATAAAGTAGAGAAAAAGGATTCTAGTGTAAATATACTGCTTGGAAAAAAAGAAGTTAAACCAAAGAAAAGTGTAGATGTACTTCCAAAGACGGGAGAAAATGGTCCAATATTTAACTATGTTTTGGGATTGCTTTTAATTGTAGTTGGACTATATTTAAGAAAAAGATCAAATATAATTAAAGAATAATCAATTAATCTCTATAAGATATTTTGCATATATTATAGAGATTTTTTATGCTTTCGTTAGATACAGAAGTAAGGCTTATTGCAGAAATAAATAATCTATTACATAAAAATACAATAATGGTAGGCATTGACTTTAATACAATAGTATAATATAATTAAACAAAGAGTATTAAATAATCGTGATTTCCACGATAAAGGCAAAACTATTGAAAGATAGTGACGCAAAGCTATAGGGTCTGTAAAATGACAGCCAGTTATCGAAAGGAGAATTTTTATGAAGAAGTTTTTTAGAGGATTTCTAACTATTGTTTTTTTGTTTTCATGCTCAAACATTTGTTATGCTAAGAATATAAGTTCCAATATAGAATTTATTAATAAAAATATTTCAGCAGTTAATAGCTTATGTGCTTCTACTAATACACAAAATTGCAGACAAGCATCATCAATACAGCAACTTAAACCATTATTAAAAACAGCCATGGAAAATAGAGAAGTTAATATAGTGATAAAATATACTGGTATGGATTGTTATAATAAAAGAAATGTAGATATAAATAAAATAAAAGACCTTACAGAAAAAATATTAAATGAAGATCATTATCTAAAATATTCAATTAGAGGATATCGTATTGGAACATCAGGATATTATGGAAATGTAAATATTAAATTTAATTTTGACTATTTAACCACAAAAGCTCAGGAAGAATATGTAGATAAAAGGGTTGAAAGTATATTATCAGATATAATAACTGATGACATGAATGATTATGCAAAAGAAAAGGCTATACACGATTATATAGTAGCTAATGTTCAATATGATACATCCTTACAAGAATATAGTGCTTATTCAGCATTAGCTAAAGGAAAATCAGTTTGCCAAGGATATTCTCTTTTAATGGTTAAAATGCTACAAAACGTAGGAATTAAAAGTATAATTGTAGAAAGTATACCTATGAATCATGCTTGGAATATGGTTTATATAGACAATAAATGGTATCATGTAGATGCTACTTGGAATGACCCTATTCCAAATGTGCCTAATAGAGTTTTATATGACTATTATAATCTTACAGATTATAAAATAAGTCAAAATATAAATGGAAAAATGCATGTATGGAATAGATATGAATATCCATCAACTAAACATTGATGGAAGTTTATAATACTTGGTTAAGTGATTATATAGATGATTATAATATAGTAGTTTATTAAATGAATACAAAAAGGAACCAATGTTAATAAGTTGGTTCCTTTTTTATGAAGTTAATTAAAGTTGCTTATATAATTGTGTAAATAATTCGTACATAAATTTTTGTTCATGGTGTATATGGTGTAGAAGTGTCTGCCAAACCTTATCTTCTTTTCCATATTCCATGATATTACATAATAAATTTATAAAATACATATCATATTGGAAAAACTCATGGATAATTTTTTTGATTTCCATTATTACATAAGGATTAGCAGGTCCATGGGAAAAACATCTTTTTTTAAGGTTTTCTACTTTCTTATTAAGTTTTGAAAAATCAGAATTTACCTTTTTAAGTTCATCTAATAGTTTTTTAGGCAATTTTTTATTAGTAAGTTTTGCTACCGTCTCTATAAATATTGGGTGTTCACTAGAAATATCTGTCCATAATAATAATTCATTAAAAACACAGGTTAAATTTGTGGCTAAAGTATAACAGTACAATTGTATCCTCCTATAAACATTATACATACATATTATATGTAAAAACTTATTAATCCGTTACAAAATAATTGTAAGGAAAAAAATATATGAATAAAATGTCAATTTTTATGTTGTGTTTTTATTAAATTATTATATAATTTAGTTACATGGTAAAATTACAGGAATTTGCCATTAATTATTATTAAAATATTTAAAATGGGAGGGAAGTTTCAATAATTATCGATATATTAATAAATCAATAATATAGGAGTGCGGTGCAAAAGTGAAAAATTTGAATCTAAGCAAAAGACTTATCCTATCTTTTACTCTTTTAATTATAGTGATAATCACAAATGGTATTGTTGGTATCAGATCTGTAAATAAAATGGATTTTAACGCTAATGAAATTGCAGGTTCTATGGATGCAATAAATAGAATTAGGCATATAGAGACCCATTTGATTGAATCTAAAGCAAGTACAATAATATTACTTAACGAAAAAGATGTAAATAAAATTAATAGATTAAAAGAAGAGTTAAACAGTTTAAGTGAAGAAACTAATGAAATAATAAGAGAATGTATTAATTCACAAGATAGTTGGTTTAAAGGAGAGGCAGAAGTATTTAAGGAGTTTCAAAATAAACTAAAAGTATACAGGAGTACTAGAGATGATATATGTAATTTAGTTCTACAAAATAATTACAATAAAGTGTTAACCCTTAAAGAAGTACATAAAAATCAGTGGATGGAACTTAATGAACTTATAAATAAGATAATAGATATAAATATTAAAGGTGGAGATAAGAAAAAAATAGACAACCACATAATTCATAAAGATTCTGTATACATAGTAAGTTTTACAATGGTTTTGGGAGTAGTATTTAGCGTGTTTTTTGTTATAAATTTATATAAGTATATAATGAAAAATTTAAGAAAAGTAATAAAATTTTCTCATAGAATTGCAAAGTATGATTTTTCAGAGGATATTGTTACAGAAAGAAAGGATGAATTTAAAGATATAGGAGATGCCCTTAATATAGCTCAAGATAATGTAAAAAAACTTATTAGTACAATAGTTTTAAAGTCAAAGGAACTGAGTAAGTTTAGTGAAGAACTTTTTGCCACCATTGAGGAAATGAATGCAAAGTTTAGTGAGATAGATAAAGATACAAATAAAATAGCAAGAGAAATGCAAGAATCTAGCTCTGCAACAGAGGAAATTTCTGCATCTGTTCAAGAAGTAGATTCTAGTATTAATATACTCACTCAAAAAGCAGTTGATGGAAGTAATGTTTCTATTAAGTCCAAAGAAAGAGCAGATAAAGTTTATAAAAATGGAGAATTAGCAGTTAAGGAAACAGAAGAATTATTTAATAAAAATAAAGAAAAAATATTAAAAGCAATAGAAGAAGGAAAGGTTGTAGAAGATATAAAAGTTATGGCAGATACTATAGCAAGTATAGCGGAACAAACAAATCTTCTTGCATTAAATGCCGCAATAGAAGCTGCAAGAGCAGGAGAGAACGGAAAAGGATTCGCAGTAGTTGCTGATAAAGTAAGGGAACTTGCTGAACAGTCATCAGAATCTGTGCTTAATGTAAAATTAACCATAGAGAAAGTAAATAAAGCTTTTAATGAGCTATCAGAAAACTCAATATTAACTTTGAAATTTATAGATTCTAAAGTTAGAAGCCAATTTGATGATTTTTCTCATATGGGATATCATTATTATAAAGATGCTGAGTTTACATCTAAAATGTCAGAGGATATAGCCTCTATGGTAGAAGAAATAAATGCCATAACAAAGGAAGTAAATATTTCAGTGCAGGGAATGGCAGATATGGTACAAGAATCTTTTAAAAGTTCATATTCTATTGAAGAGAGTATAAAGGAATCATCTGATGCTATGGAGCAAATAGCAATAACAGCACAAACACAATCAGAACTTGCACAGAATTTAAATGAAATTGCTGAAAGGTTTATATTATAATATTTATAAAGATAAAAACAGTTACTATTGTGTTTAAAGAATAGTAACTGTTAATTATTTAACTTATTTGTAGGTAGTTAATTATAGTCCTATAGAACACATAGGGATAGTTACAAGAAGTAAAACTAATATAGGGAATATAATTTGAGTCATAGCTATGTCAAAATAACCTTCTTTATGAGTAAGTCCACATATGGCAAGAAGAGTAATTTGAGCTCCTTGATGTGGCAAAGTATCAAATGTACCTGATGCAATTACAGAAATTCTATGGACATATTCTAAATTAACTCCCATATTAATGTATGTGTCTTTTAAGGACTCAAAAGCAATTCCTAAACCACCAGAGGCTGAACCAGCAGCTCCAGATGCTATAGCTACAGTGATTGCAACAAATAACATAGGTGACATTTTCATAGTTTTTAATTTATTAATAATTTTTTCGAAGCCAGGTGTTTCTTTTACAACACCTGCGAAACCAACCACTATGGCTGTATTTAATATAGCTGTAGCTGAATTGATAGCTCCCTTATTTAAGGTATTTATCCATTCTGAAGGACTATCTATACGCTTCCAAAGTAGAACAATTGCAGAAATAATTCCTATTGTAACCGCACCTTCCACAGGTAGCTCTATAATATTGAAGCATATTAAGATTAATATGGCAGGTATTGCAGACATTATTGGATTTGGAAGGTCTTTATTATTTTTTGAAATATTTTTATCATCTATATACGGAATTATAGTAGGATCTTCATAAAAAGTATACCCCTTTTTAGTTAATTTACTTGATCTATATTCAAACCAAACACAGATTAAAATTAATTGAGCTAGAGCTGATGCTATAGCAGGTAACAAAGCTGCGGTGGAGCTTGTTTCAAGATATCTCATAGCAATTATATTTTGAATGGATGGACTTCCAGGACCTGTCATAGACCATGTCCATGCCCCTGCTGATATAGCAGCTGGTATAAGTCTTCTTGATAAATTAGCACTTTTAAATAGCTCAACTGCTATAGGATACATAGCAAAGAAAACTACAAATCCACTTATTCCGCCATAAGTTAATAATCCAGTAATAATCATTATTAAAGGTGCTACAAATTTTCCATTGGTTATTTTAATAAGGCTATGTGCAATGGATTCAGCAGCACCAGTTTCTTGCATTATAGAGCCAAATACTGCACCTACAAAGAAAACTAGAAAGAACTTTTCTACATAGTTTGCTGCAGCGTTCATGTATGGTCCAAGCATTGTATTAAACATTGGAAGCCTTGAACAAACTATTACAAACAATGATACAAGGGGGCCTAAAATTAAAGCACTAACTCTTTTAAATGCTAATATTGTAAATAGCACTAGAGCGATTATAATAATCCATATATCCATAATAAAACCTCCATTATTTTTATTGAATACTCAAACTATTTAGCTAAAAAATGTTTTTTTAAAATCCTGTACATTTTATTTGTACAGGATTTAAAAACATGTAAATTATATTATTTAAAAAGGCTACCACTTATAATCATTTTTTGTATTTCATTTGTTCCTTCATATATTTGAGTTATTTTAGCATCTCTCATCATTCTTTCAACATTGTAATCTTTCATATAACCATTTCCACCAAGCATTTGCACTGCTTCAACAGTAACTTTCATTGCCAGATCTGTACAAGCAAGTTTTGCCATTGCCGCAGAAACTGAATAAGGTTTTCCTTCATCTTTATCAAGAGCAGCTTTATATAGTAAGTATCTAGCTTTTTCAATTTCAACAGCTAATTCAGCCATTTTAAATCCTAAGTATTGATTTTTATAAATAGGTTTTCCAAATTGAACTCTTTCTTTCATATAGTTTTTTGCTATTTCAAAAGCACCTTCTGCTATTCCAAGGCCCTGAGCTGCAACTCCTATTCTTCCACCATCAAGTGTGCTTAAGCCTATACCAAGTCCTTTACCTTCTTGTCCAATTAGATTTTCAGATGGAACTTTACAGTTATCATAAATAACATCTGATACTTGGGCAGCATTTATACCACACTTATTTTCAACTTTACCTATTGATATTCCAGGGAAATCTTTTTCAACTATGAAAGCTGATATTCCTTTAGCTCCTTTACTTTTATCTGTTATAGCAAACACTACAAAAGTATCTGCAACAGGTGCATTTGTAGAAAAACACTTAAGTCCATTTATTATATAATGATTTCCTTCTTTAATTGCAGTAACAGAACCGTTACTTGCGTCAGAACCAGCTTCTGGTTCTGTTAAATTAAAAGCACCAATTTTTCTACCTGTTGATAGATCAGGAAGATATTTTTTCTTTAATTCTTCAGAAGCGTTGTTATATATAGCACCACTGCAAAGGGAGGCATTTACTGAATAACTAATTCCAAGGGATGCATGAACCTTTGAAATTTCTTCAACAGCTAGTACATATGCTAGATATCCTCCACCAGTTCCACCATATTCTACTGGATAAGGCAGTCCTAAGATACCCATTTCACCTAATTTTTTATAAGCTTCCATAGGAAATTCTTTATTTTCATCATTTTCAATTGCTATAGGTTTAAGTTCCTTTTCCGCAAATTCTCTTACTCTTTTTACTAACAGTTCTTGTTCTGGTGTTAAATTAAAATTCATATATAATTCCTCCTTAAAAATAAGTCATATTTATTACTTTAATCCCATAGGTTTATCAAAGAAGATTCGACTATCCATAAGTTTAGGCTCGCCGTCCATTTTAGGTTTGAAATCCATTAAATCCAATACATCTTTTTGTAGGTTAATTCCCGGAGCTATTTCCGTTAGATATACACCATCATCTTTAAGTTCAAATACAGCTCTTTCGGTTATATACATTACAGGCTGTTTTATTTTTTTGGCATATTCCCCACTGAAAGTTATTTGTTCAACTTGATTTATGAACTTTTTGGATCTGCCTTCTTGCAGTATGTTTAATTTTCCGTCTTTTATTTCTATTTTTAATCCGCCAGCTGTAAATGTTCCGCAGAAGAATACTTTTTTAGAGTTTTGAGTTATATTTATAAAACCACCACATCCAGCTATACGAGGACCAAATTTACTTACATTTATATTACCGTTCTTATCCGTTTGAGCAAGACCTAAGAATGCTAGATCCAATCCTCCACCATCATAAAAATCGAATTGATAAGCTTGGTCTAATATTGATTCTGGGTTAATACATGCACCAAATGCAGTTCCACCTTCGGGAACTCCACCTATGGCACCTGCTTCTACAGTTAAGGTCATATATTCTCCAATACCTTCTTCATTTGCTACTGAAGATATAACCTCTGGTATTCCTATTCCAAGGTTTACAGTAGTATCAGGTTCAAGCTCCAAAGCAGCTCTTCTTGCTATTACTTTTCTCTGATTTAATGGAGCCTTTTCTACACTACTTACAGGAATTCTTACTTTACCAGTTCTTGCTGATTCAAACTCACATCCAAAACATTGTTCATGATCTTCAGGTTCGGCAATTACAACTCCATCTATATATATTCCTGGTATTTTTACAAGACGTGGATCAAGTGTGCCACATTCTACTACTTTTTCTACTTGTACTATAACAATTCCACCGGTATTTTTAGTGGCTTGAGCTATGGATGTAACCTCAAGGCTAGCTACTTCATTCTCAAGGGTTACATTGCCTTTTTCATCTGCAAAGGAGCCACGTAAAAAACATATATCTATTGGGAATGATTTATATAGTAATCTTTCTTCGCCTTTAATATTTATGACTTCTACAATATCTTTTTTTGTTATTTCATTTAGTTTTCCACCTTCTAATCTTGGATCTACAAAAGTATTTAATCCTACATGGGTTATTGTGCCTATTCTTTTTCCGGCAATATCTCTAAATAATTGGGAAAGTGTTCCTTGAGGTAAGTTATAAGCCTCTATTTCATTATTTATTGCCATCTTTCCAAGGGAAGGTGATAAATTCCAATGTCCACCTAAAACTCTTTTTGTCATACCAATATGTGCAAAACGATCTGCACCTTTTCCGTTTCCATCTCCTTGTGCCGCCGCATACATTAAAGTTAAATCTTTAGGACTAGATGTTTCAAGAAAACGATTTTCAAGTGCTTTTGTTAAAGCTTCAGGACAGCAGCTCCCTACAAATCCCCCAGTTACTATTAAATCTCCATCTTTAACTAAATTTGCAGCTTCATGAGCTTTTAAAAACTTTACCCCCATAGATAATCAAATCTCCTTTCATAACTTTTATGAATATGATTTCTAGTAACCTTTAAAGTTAGATTTTCTCTTTTGTAGAAAGGCCTTCATACCTTCTTTTTGGTCTTCTGTTGCAAAACATAATCCAAATATGTCTGCTTCATATTTATAGGCTGATTCTGTATCCATATTCATACCGTCATTTATAGCTGCTTTTGCTAAACTAACAGCATATGGTGCCTTATTCATTATCTTTTGAGCTAACTCTCTAGCTTTATCCATTAATTCTTCAGATTCATAAACTTTATTAGCAAGTTGTATACGATAAGCTTCCTCAGCATCTATCATATCAGTAGTAAGTATAAGTTCTTTAGCTGTTCCTTTACCAACTAATCTTGGAAGTCTTTGAGTACCTGCAAATCCAGGTGTTATTCCTAAGTTTACTTCTGGTTGTCCAAATTTTGCATTTTTAGAAGCAAGTCTTATATCACAAGCCATAGATAATTCACATCCACCACCTAGTGCATAACCATTAACAGCAGCTATTACTATTTGAGGCATATGCTCAATATCAGAGAATACTTTTTGAGCAAGTCTTGCAAGTTCTCTTCCTTGTTTTGCATTTAGATTTTCCATTTCAGTTATATCTGCTCCTGCAACAAATGCTTTTTCGCCTGCTCCAGTTATTATTACAACCTTAACATCATCATTTTCAGAGATGTCTTTTATAGCTACTCCTAATTCGTTTAAAGTTTCACTATTTAAAGCGTTAAGAGATTTAGGTCTGTTAATAGTTATTTCTGCTATACCATTCTCCTTTTTTAAAATAATGTTTTTCATTAGAACCCCTCCTATATGATAAATCTTATAATTAATAACTTTGCTTAACAAAAGGAAAATTATTATCAAAATTTGTTATTTGATTATTGTTTTAGTGAAATTTTGTTGTTTTCAAGTATTTGAAAGAATATTCCGTATTTTGATTATATTTTGTTTTTATATTACAATATTACTATAGCATGATTGTATTTATATTAACAAGTACTTACTTTTTTGTTAGCTGGTTACTTTAATGTAACTATTTTAAGCTTTGTTATAACTTATGGAGGGGATTAACTGTGAAAAAAATGACAAAAGATGTTTATGTTTGCGGTGTTGAACTTACTACAGATATATTAGGGGGTAAGTGGAGAATAATGATACTTTGGTATCTAAGAAAGAAGAGTCTTCGTTTTGGACAATTAAAGAGATCCCTAAAGGGTATAAGTGAAAAAGTATTAAGTCAGGAATTAAAGCAGCTAACTGAATTGGGGCTTATCGATAAAAAGGTGTATTATCAAAAACCACTTAAAGTAGAGTATAGTTTAACAAATTATGGTAGGACATTTTTACCTATACTTTACTCTATATTTGAGTGGGGGGCGCATTATGCTGAAATATTTAATATACCATTAATTATAGATGACGCTACTATAGATGAAGTTTTAAACGAAAAAGAAAGATTCTTGGTAGAATATAAAAATAATAAATTGGAATCTGTGAATTAATTAATATTTTAATGGGAAAAGGGTTAGAACAACATAAAATTATACGACAAAGTAATAGTAAATGTAGATAAAATGTATAAAGAAGAGATAGCCAAGCTATCTCTTCTTTTCTTATGCATTGTCTAAAACTGTAGATTTTTCTTGTTCTATTTTGTAGATTTTATAAATATTTTTAAGTTTTATCATGATAATTGCCGATTTTCTTAAATATCGGTATTGTCACCTGCCTTTATAAATAATAAAATATATTATATAATAATGTTCATCATTTTAGTGTTAACAAAATATTGTCATGTCATACTTAGCTAAATTTTAAAGGAATATTAAATATTTGAAAAGAAAGGGATGATTAAATGGATTTTGATTATTTTAATCAGATTATAGTGTTGTACGGAAGTAAAATAATACTAGCAGTTGCAACATTGGTTATAGGACTATATGCAATTAAAAAGATAGTAGGACTTTTATTTAGAAGATTTTCTAAAATAGGATTAGAAAAATCTCTACAGTCTTTTTCAATATCCTTTACTAGTATAGGATTAAAAATATTACTTGCTGTAACAATTGCTTCAATGCTAGGAGCAGAGATGACTTCTTTTGTTGCAATTCTTGGTTCGGCAGGATTAGCAGTTGGACTAGCACTACAGGGAAGCTTATCAAATTTTGCAGGAGGAGTTCTTATTTTAATATTAAAGCCTTTTAAAGTAGGGGATTACATAGAAGCCGCAGGTCACAGCGGAACTGTATCTGAAATACAGGTTTTTTATACTATATTAAATACACCAGATAATAAAAAGGTGATAATTCCAAATTCTAATATATCTAATGGTAGTGTTACAAATTATTCTGCTAATACTACAAGAAGAGTAGATTTGGTTTTTAGCATAGATTATGACGAGGATATAGAAAGAGTAAAAAAGGTTTTAACAAATATTATAGAAAGTAATTCTTTAATATTAAAAGAACCAATTCCTCAAATATTAGTTGGAGAACATGGAGATAGTTCAGTAAATTTATATGTTAGGGTTTGGTGTGAAAATAAAGATTATTGGAATATATATTTTGGATTAATGGAAAAAGTAAAAGTAGAATTTGATAGAGAATCCATAAATATACCATACCCTCAGGTAGAAATACAGTATAAAGGAGAAAAGGCACAGTAATAGTGTCTTTTTTTTCATGAGTCAAATGTTAAATAAATAACATGAATATTCTGGATTTTATCAAGTAAATGTTATAAAATATATAGTATAATCCTATATTTTAAGAAATAAGAAGAGGGAATTAGATAAATACATTTATGCCTTTGCTTAACATTGATTAAGTATTAACAATTAAATAGGGGGAATTGAGATGGATTGGGAAAATATTTACAAAAGTAAGCTGTTATCACCAAAGGAAGCTGTTTTAAAATTAAAATCTGACGATAATGTAGCGATTGGACATGCCGCTAGTGAACCTAGACTTTTAATGAATGCTTTAGTTTGTAATAAGGAAAGTTTTAGAGATTTAAAACTTTATCAAATGATAGCTTTAGAAAAGAGTGAATGTGCTAAAAAAGGTATGGAAAAACATTTTAGTTATAATTCTCTTTTTGTAGGAGGAGGGAGTAGGGAAGCTATAAATGATGGAAGAGCTGATTATATTCCTTGTTTTTTTTCAAGAATACCAAGACTTTTTAGAGAGAACTATATAAAATTAGATGCGGCATTAATACAAGTTGCACCTCCAGATGAGCATGGATTTTGTAGTTTTGGTGTTTCTTCTGATTATATAAAACCAGCAGCAGAATGTGCAAAACTTGTTATTGCAGAAGTAAATGATAAGATGCCAAGAACTTTAGGGGACAATTTTATACATGTTAGTGACATAGATTATATAGTTGAAAATTCTCGAGAGATACTAGAGCTAAAACCTTCTAATATAGGTGATATAGAAAAGGCAATAGGAGAAAATTGTGCATCTCTTATAAATAATGGAGATGTTTTACAATTGGGCATAGGTGCAATTCCAGATGCAGTACTTTTATTTTTAAAGGATAAAAAGGATTTAGGAATACATTCAGAGATGATTTCTGATGGGGTGGTAGATTTAGTAAAGGCAGGGGTAATAAATAATAAGAAAAAGACTTTGCATCAAGGGAAAATAATTGTTAGTTTTTTAATGGGAACAAAGAAATTATATGATTTTGTGGATAATAATCCTATGGTGAGAATGTATCCTGTGGATTATGTTAATAATCCTGTAGTTATTAGTAAAAATGATAATATGGTTTCTATAAATTCCTGTATTCAAATAGATCTTATGGGTCAAATAGATGCAGAAACCATAGGCTTTACCCAAATAAGTGGTGTTGGTGGACAAATAGATTTTATAAGAGGAGCAGGTCTTAGTAAAAATGGAAGGTCTATCATTGCAATACCTTCTACTGTAGGAAATGGAAAAATATCTAAAATAGTTCCTCTATTAGATAAAGGAGCAGCAGTAACTACCACAAGAAATGAAGTGGATTATGTAGTTACTGAATACGGAATTGCAAGACTTAAAGGTAAAAATTTAAGGGACAGAGCGCGAGAACTTATTAAAATAGCTCATCCTGATTTTAGAGAGGAATTAAAATTAGAATATAAGAATAGATTTAAAGAAGAGTTTAAAAGAATAGGATAAATACTAGTGAATAGGAGCTGTTACATTAGCGATTTTTTAAATCACTATGAACAGCTTTTTTTTTAAGAAAATATTAAGGTTTAATTAATGTGTTATTCATGGAAAATTTTGATAAGCTGTGATAAAATTATTTCATATATGAAGTAATTTGTACTTAACATAGGAAAATACATATAAAGAAAGGATAAGTATGGAGGATAAAAAGATTTTTGAATTATTAAAAGATATAACAAATCTTTCTAAACTTATGAATAGAAAGTTAAATGCTAAAATGGATGGAAAGAAGATAAGTCCCTATCCTATAATTATACTAAATCAACTAGATAGAAAGAAACCTACAACTTTAACGGACATAAGAGAAAAATTAGGTATACCCAATAGCACTATATCTACAGTTCTTGATAAGCTTTTAGAAAAAGGATTAATAAAGAAGGAAAAAGACGAAACTGATAAAAGAAGAACCTTTCTTTATCTTACAGAAAAGGCCTATGAAGAAGAAAAAAAGATAATAAAACAGCATGTTGAAGTATTTAAGGAAGTTTTATCTAAAGCTACAGATGAGGATTTAAATACTTTAATAAATAGTACTAAGCTTTTTATTAAATTAATTGAGGAAGATAATAAGGAGGACGAGTATAAATTATGAAAAAAAGGTTTAAATTAAACAAAAAATATCTAATATTTGGAGTAATAGCTGTAGTTATAATACTAGTAGCATTTTCAACAATTAAAGGGAAAAAGGATAATTTCACACAAGTAAGTACAAATACTGTTAGTAAAAAGAATTTAAATAAAGTTGCTACAGCAACAGGAAATGTGGAGGCAAACCATAGAAATGATATAGCTTTAAATCCATCTCTAAAAGTGATTAAAGTAAATGTTAAAGAAGGACAAATGATTAAAAAAGATGATGTATTAGTGGAACTAGATTCTAAAGATTTAAAAACCCAACTGGAGAAAGCTGAATTAAACCTAAAGAATGCCAATGATACATTAGCACAATTTCAAGGAGCAGAGGTGGAAAATCAGAAAAAGACAGCATCAGGTTCTTTAGTACAAGCAAGACTTGCATTAGAAAATGCTAAAAGTACCCATGAGGATTTATCAAAGAAACTATCACAAAACAAGAAATTATTTGAAGGAGGATATGTCTCTCAAAATGAATATGATGCTTCTGTAAAAGCGGCAAAAGAGGCTGAAAATGGAGTTAAAAATGCAGAAGCAGCATTAAAAAATGCAGAAAATAATTTATCAGGAATAGATATATCTACAAATAATAAAATAATATCTCAAAGAAATCAAATCGCAATGATTCAATCAGATATAAAATCCATAAAGGATAAAATAGAAGATTGCTATATAAAAGCAAATGTTTCCGGAAAAATAGTTAGAATGGATGCAAAGGAAAATCAATATCCTAATGCAGGAGAAATGATAGTAATAGATGATGTTTCTAAGTATAGAGTTAATGCAGATATAAATCAATATGATGCAGTTAATATTAAAAAGGGACAAAAGGTAAATATAAAAATTAAAGGTATAGATAAAGAGTACAAAGGTAAGATAGAAGAAGTAGGAGAAATTGCAGAAAAGAAAATAGCTAAAAGTGGTGCTGGAGCAGATGCAGAGCATAAATTAAATATAAAGGTAGCTTTAGACAAATCTGATAGTAAGGTAAAACCAGGTTACGAAGCAGATTTAGAAATTATATTACAGGAAAGAAAATCATCTTTAGCTATAGGATTTGATGCTATAAGACAGGATAAAAAGGGAGGAAAAAAATACACATATGTATTAGATCAAGATAATGTTGTAAAGAAAAGAGAAATAAATACAGGATTAGAAACGGAATATGATGTAGAAATTTTAGGCGGATTAAAAGAAGGAGAAAAATACATTATAAATCCTCCAGAAAATCTAAAAGATGGAGAAAGAGTTAATCCTGCAGGTGAATAGTAGGGGGTGGAGAAGTGATTATAAAACTTGAAGACATTGAAAAAATTTATGATACAGGAGCCATTAAACTAAAAGCCCTAAATAAAATAAATTTATCTATTGATGAAAAAGAATTTGTGGCTATAATGGGTGCCTCAGGCTCTGGAAAGTCCACCATGATGAATATATTAGGTTGTTTAGACAATATATCTTTTGGGAAATATTATTTAGATGGTGTGGACATTTCCTCACTAGACAGTAATGAGTTAGCAGCAATAAGAAATAAGAAAATAGGTTTCGTATTCCAAGCATTTAATCTACTGCCAAAACTTACTTCTATAGCTAATGTTGAATTGCCTATGATGTATGCCGGAGTACCTAAAGAGGAAAGAAAAATTAAAGCTCAAAAAGCATTAGAAAGAGTGGGACTTGGAGATAGGATATATCATAAGCCTACAGAATTATCTGGAGGTCAAAAGCAAAGAGTTGCCATAGCCAGAGCTTTAGTAAATGATCCTTCTATATTATTAGCAGACGAGCCTACTGGAAATTTAGATAGTAAATCAACAGTAGAAATTATGGGAATTTTTCAGGAGCTAAACAATGAGGGAGTTACAATCGTTATGGTTACTCATGAAGATGATGTGGCAATGCATACTAAAAGGGCAGTAGTTTTTAAGGATGGAAACATAATTTCAGATAAATTAATAAATGAAAGTGAAAGAATTATAGTTGGGGGGCAGCAATCATGAACATATTAGAAGGTTTTCAATCTGCCCTACAAAGTGTAAAATCTAATAAATTAAGATCTTTTCTAACTATGCTGGGTATAATCATTGGTATATCTTCTGTAATAACTATAGTATCCATAGGAGATGGGGCCAAACAATTTATAACAGGAGAATTTGAAAATATAGGAACCAATCTTATAAATATGAAGATGAGTTCTTCTCCAGACATTACTATAGAAAAAAGAGATTATTTTACCATGGATGATGTTAAGCTTTTAAAAAATAAAATATCAGAAATTGAATATGCATCACCTGAATTGGGGTTATTTGGCAAAGCCAAAGTAGAAAATAAAATGAAACAAGCAAGCATAATGGCAACAAATGAGGATTCTAAAAAGTTTTATAATTTAAAGATGATGCATGGAAGATATTTAAATGAACATGATTTAGAATCAAGAAGGGCTGTTGCAACAATAGATGATAGAACAGCTAAACACCTTTTTAACAGAGTAGATGTAGTGGGAGAAAAAATAAAATTTAATATTGGAGATAAAAATATAGATTTAAGTATAATAGGCGTTTTTAAAGATCCTAGAGGGAATATGGGAGATGCTTTTGGTGGTAGTAATATGCCAGGATTTTTAACAATGCCATTAACTATAGTAGATAGACTAACAGAAGATACTGATATACGTGGGATTTCTGTTATGTTGTCTGATATGAAGAATGCAGATCAAGTATCCAATAAAATGATAAGACTTATTGAAAATAAACATAAAAATAGGAATAAGTATACAGCGGAAAAAGGATTTAAAGAATTAGAAAGTATCAATAAGGTGTTAGGAGTAATAACTATGGTTCTAGGGGCTATAGCTGCAATTTCTCTTTTAGTTGGAGGAATAGGAGTTATGAATATAATGCTTGTCTCTGTTACAGAGAGAACTAGGGAAATAGGTATAAGAAAAGCCATAGGAGCCAAGACTCGGGATATAAGGATTCAATTTCTAATGGAATCCATAATACTTTGTCTAATCGGAGGAAGCGTAGGAACTATACTTGGTATATTAGTGGGGAAATTTGCAGGAGGTCTTATAAATATTCAGATTGTAGTATCATTGAAAGTTATATTAACAGCCTTTGGGTTTTCTTCAGCAGTTGGAATATTCTTTGGACTTTATCCAGCAAATCAAGCTGCACAATTAAATCCAATTGATGCACTAAGGTACGAATAAAAGAGAGGATGAGAGTATATGAAAAAAATTAAAAAAGTTATATTATGCCTCTTAGTTATTAATACAATATGTATTTTGCCTAAATCACAGGGAACTATAGTAAAAGCTAAAGAAAATAAAGGTGACGTTGGACAAATTCTTGATTTGGATAGTTTAATGGAAAAGGCCGTAGAAAACTCTATAGAAGTTAGGAATAGAAAGAGTACTATAGAAAGCTTAGAAAATGGATTTCAGGATAATATAAATGGAACAGATTCAATATATGAAAGAATAGAAAAAAATGAACGATTTAAAAAACTTCAAAATAAAAGTGAGAGAACAGAAGATGAAGAAAGAGAATATGAATACTATCAAAGAAATTTTGGAATTCCAATAACAGGAGAATATGAACTTTTTCAAATGCTACAATCAGCTAATAATACTCCTGTATTGGGTGAATTTGAGATATTTCAAAATAAAAATGCCCTAGAAGTGGATAAAAATTCTGTAAGACAAAGGGTTTATGAAGGATATAGAAGATTTTTAATGGAAATGGATAAATTAAAACTTGCAAAGGATAAATACAAAAATGTAGAAGATGAATACAAAAAATCGGAAGTATCCTACAAAACTGGAGTTCTTTCCAAAACAGATTATTTAGCTAAAAAAGCTGAGTATTTAAAGGAAAAAGGAGAATTTTCAAATATAGATAGGGAATTTCAAAAATATAATATGGAATTTAACAAATTAGTAGGAGAACCATTAGATAAGAAATACTCAAGTTATAAAAAGGATTTTAATTTAGATAAATCCATATTAAAATCTCAAGATGAGTATATAAAGGAAGCTTTAGAAAATAGAATGGAAATAAAAAATGGGGAAGAAAATATTTTAGTAAGAAGATTTGAAAGTGGGTCAGCAAAGGCAGTATTTTCTAGTGAACATAATAGAGAAAGAAAACTTGCAGAACAAAAGATACAAAATGCAGAAGATGAATTAGAGCTTAAAAAGCTAGACATAAAAATGGAGATAAATTTATTATATAATGATTTTGAAATAAAGCTTGTAAGGTTAAAAAATTTAGAAGAGGGTTATAAACAAGCTAAAAAAGAATATGATGAATCCTATAAAAAATATAGCTTAGGAATGTTAAGTAGGCTAGATTTTAATAGAAAAAATGCAGAATTTATAGAAAGCAGTATGGATTATAAAGAGGCGGAAAGAGAAGCATATGTTGCAAAACTTAAACTAGAATTTGCAGCTTCTGTAGGAACGGATTCAAAGAAAGTATTCTATCAATAAAGGGGGATAAGAATGAAGAAAGGAAATATAACAGCTTTAATTTTAGCAACACTTTTATTTGCTAATTCATCCACAGTGGTTTTTGCCATGAATAATGCTGAAAATAATTCCCGGGAAATAGAAAATAAAGAAGAAATTAAGGTTATAACTATACTGGGAAAAGATAATGAAGAAGAATTAAATCTAAATATGAAAGAAGTTATGGAAAAATTAGAAAAGGATAATTCAGAATTAAAGCTTATGGAGGGGAAAATAAACCTTTTAAATAGGCTTTATGATAGAGATTTAACCTTATCTCAAAGTATAGATAATGATAGGGATATTTCAATAAATTATAACAATGTATCCTTCAGAAGGCAACAAATGCTAAACTTTAGGCAATCAGCTTTAAATGTAAAATCTGCAAGAAAAGATAAAGAAGATAAAGTAAAAGAAATAAAAAGAGAACTAGAAAGAAACTATTTAAATGTTTTAAATTGTAGAAGAGATATAAAAAATACAGAAGAAACTTTAAAGAATTTAGATATGCAAATAGAGAAATTACAAAGATATATAGATGAAGGTAAGGCAAGCTCTACTTCTATAGAGCCTTTAAAAGTGCAGAAAACTCAACTTAGATCATCTCTTAATCTACCAAAACTTCAAGAGCAAGAATCACTTTTAAAGATAAAACAGTATTTAGGGTTAGATCAAACTAAGAATATTAAACTTAATTTAGAATATGCTAATAAAGAATTTAAGCTATATAATCCAGAGAACATAGATAAAATCATAAATGATAGTATTGAGAAAAATTTTGGATTATATAAAATGAATGAAGGACTAGAGTTTTTAAAAGTAGAAAGACATATTTATGAAAAATACGGAAGAAATATAGAAGTGGAGTCAACAAATTTAGATATTAGAATGAAGGACATGCAAAATTCTATAGAAGATTATAAACTAAATTTAAGAGTTAACTTCTGGTCAGCCTACTATAAATTAAAGGGAACAGAAGAAGCGGTAGATGTGGCAAAAGCGAATTTAGATCATTCAAAAATGAAATACGAAGAAACAAAATATAGATTTGATCAAGGATTAGAAGATAAAGTTCAATTAGAGTCAGCTAAATTAGACTTTGAGAAAAAGAAAATAGAAGAAGAAAAAGCAATAAATGAATATATGATTACTGTACAAAGCTTTAAAGATACTTTAGGGATAGGAGAATAATTATATAAGTTTGGAAGTAAAGAGGTTATGTATAGCCTCTTTATTATTTTTATGGGAAATGATATACTTATTAGCATAACTTACTTATACATTGGGAGGAAAAATTATGAAAAAGAAAATATCCATCATTTTAGCTATAATATTTATATTAGTTACATTTTCATCCGCTTTTGTTATGTTTAAGGGAAATAGAAAAGATTCTAAAGTTAATAGCAGAGAAAGTAAACAAAGTAATGTGGATTTTTATGTAAAATATGCCTATGCTGACATAGACATGGATCAGATTATTCAAGATGTAGATAAAAAAGATGACGATACTTCAGCAGATTATATTTTTATAAGATTTAGTGCAGAAGTTATTCAAAACAATGATGAAACTTCTATAGGCAATCCTAATAATTACAAATTAAATGGACAACCTCTTCCAAAAGGCAGTGAGTCTTTTATAAGAAAGGAAATGCCACAGCTTTTAATATTTAAAATTCCTCAAGGAACCTTAAAAAACAAAAATTCAGGACATACCATTGAAATTAGTAAGAATGTATTAAATGGGAAAAATAAAATAATAGGTGAAACTAAATTATTACTTCCATATAGTGAACCTATTAAAGATGAGGGACAAAATAAGAAGGATGATAATAAAGAAAAAAATAATAAGGGGCAGGATGTTAAAAATGGACAAAATAAAAATGTATCTAATGTTCCTAAATATAAAGTAGAAGTAGGAAAAGGTATACCTTATAATACATTAGTTCTTGTAAAAATTCAGGAAGGAAAAGCTGAAGATTATAAAGTAAGTATAGACAATGTAGGTCTAGAAATAAAAGAAACTAATGAAAAACAGAAGGTTCATGTAGGCTATGTAAAAAAAGATTATAGTTATAGTGAAGTTTTACAAAAAGTAAAAGTTGAGAAGATAATTAAAAAATAAGTTTAAAATACCTCCTAGCTAAAAAAGTTAGGAGTATTTTTAAATACACTGTAATTAATTACATAAGTAATATATAATATATATGTTGGAATTATTTATTTACATAAAGGAGGACTATATATGTTTGCTAAGAAAAGTAAAAAAGCAATTATATCTACGTTAATAACTAGCTTTATATTTGCACCATCAGTAACAGGAATTTCAAAGGTAGGAGCAAAGGCAGAAGTTGTGAGAATGCCAGGACTTAATAGATTTATTACAGCTCAAAATGTAGCCAAGCAAAGCTTTGGTACAGCAGAGAATGTAATATTAGTTAATGGTCTTGGATATGCAGATGCAGTAAGTGCGGCCCCTCTTGCTAAAATATTAAAAGCACCTATCTTACTTACAGATGCTTCAAAAAAACCTTCTGTGGATTTGCTAGAAACTCTAAGTAAACTAGGAACTAAGAAGGTTTATATAATAGGAGGAGAAGGAGTTGTAACTAAAACTCTAGAAATAGAATTAGCTAAAAGCTATGCAGTGGAAAGAATAGCAGGAGCTCCTAAAGATGGTAGATATGGAACTAATGCAGCAGTTGCTAAAAAGGTTATAGAAAAAACAGATGCTAAAGGTGGAATACTAGTAAGTGCTGAGGGTTATGCGGACGCACTGTCAGTAGCATCAATAGCTGCAAGTAAAGGATATCCTGTATTGTTTGCTAATAGAGAAGAAATGCCTAAAATAGTAAAGGATATTGCTTCAAATCTTAATGTAAAAGCTGTTGGAGGGGAAGGAGTTCTTCCTAATAAAGTTTTAGAAAGTGTAAATGCCAAGAGAATAGCTGAGGGAAAAGATAGATTTGAAAGCAATTTAAAAGTTTTAGATTACTATAAAGATGATTTGAATTTTAAGAATATATATATAGCAGCAGGTGGAGATGACAGTAGATATAAATTTGCTGATGCATTGGTTGCTTCTGCCGTAGCAGGAAAAGATGGAGCACCATTAGTGTTAAATGGACTTGGAGCTAATGATGAAAATAGAAAAGCTGCTAATGAGTACATAAAAGATAATATGAAAAAGGATGTAAAAGTTACCATAGTAGGAGGAGGAGCTTCTATAGATGGATTTATTGAAAGTGAACTTTTAGCTAAGGCACAAAAAATAAATGAAGACTCAGGAGAACCTGAATCCGAAGACATTGTTGAAGGAGACAAGCAAGAACGTGAAGACTCGGAAGATACAAAAGAACCAACTAAAGATGAGTCAGAAAAAGAACCGGAAAAGGAAACAGAGAAAGAAAAACCAACTACAGAAGAGCCAGAAAAAAAAGCCAGAAGAGGAAAAACCATCTAAAGAAGAATCAGTAAAACAAGGTTTTATAGGTGTTTCAAAAATAGAGACCACAAGTACAAAAGAAATAAAGGTAGTATTTGATGAAAAGGTAGTAAAATCTAGTGCAGAAATATCCATATACTATGAAATGGATGGAAAAGATTTAACTTATGATAATTGTGATATAAAATTATTAGATGATGAAAAAACTGTAGTAATAACCTTTAAAGAAGAGTTTAAAAAGGGTACTAAAAAGAAATTTAAAGTAAAAGAAGGATATATACAGGCAAAAAATACTGGATATCCAGCACAAGAAAAAGAAGTAGAATTAATATTTAATTAAAATTATGGAAGGAGTCGTAGATAAATTTCTCTACAGACTCCTTATCTTTAATTTGCATAAAATCAATGTAATGATGAATAAATTCTTTCAATATTAACAATAAGTTAAAAAATAATATGTTGACTTTAAAGAGAAAAAGTTGTTTAATAAAACTGACTGGTCAGTATATAATTACTGTACTGCCTTATGCAAATCTATAAAAAAAAGAGGGAGAAGGGATGAATTTTTTTAAGATAATAAAAAATGATATTAAAAATATTCTAAGCAATAAAATGCTTGCAATAACACTAGTTGTAGTAATGTTACTTCCACTTTTGTATGGTGGTCTTTATTTAGCAGCCTTGTGGGATCCATATGGGCAAACAGAAAGTATACCAGTAGCAGTTGTAAATCTTGACCAGGGAACAGAAAAAGAAGACATTTTCTACAGATTTGGAGGAGACTTAGAGGATGCTCTAAAGGAAAATGACGACATAGGTTGGCAGTTTGTAGAAACCGTTAAAGAAGCAGAAGAAGGTCTTATGGGAGATAAATACTATGCTATGTTAGTTATCCCCAAAAATTTTAGCCAACAAGTAATGGATGTAGAACATGGTAAACTAAAAAAGCCTAAAGTAGTATTTAAGGCAAATAAGAAAAAGAACTACATAGTTGGGCTTATAGCTGATAAGGCCGCTGGTGCTGTGGAAAAGGGAATAAAAGAAAAAACAGGGGCCAAATTTACCGAAATCATTGTAGATAATTTAGAAACCCTAAGAGATGGTCTAGAAACAGCAGCAGATGGAACCTATACTATGAAAGACGGAATAACAGAACTTAAAGACAAAATTCCATCTTTGGACAGTGCACTAGGAAAAATTGAAGATGGTTCTTCTACATTAGAAGAAAAACTAGGAGATGCTGAGGATGGAGGAAACAAGCTAAAAGAGGGTATAGGTACTTTAAAGTCAAAAGTTCCTGACCTATTAGACGGAATAGATAGGCTTCATAATGCCACAGTTAACTTAAACGAAAACGTAAAAGATGCTTATGATGGAAGTACCCGTTTAAGAGATGGAGCTTTAGGACTTAATGATAAACTTCCAGATTTGTCTGATGGTGTGGACAGCATATTTGAAGGTTCTACGGCTTTAAAAGAAGGTATTGGACAAGTTGATGATAAGATGCCAGATTTAATAGATGGTGTTCAAAAACTTAGAGATGGTGCTCGTGATCTTAGAAATGGAATTAGTAAAGTAACAAAAGGCATAGAAGACAAACTAGGTGATGAAAAGGACAAGAAGAAAAAGTCTGAAGAAGAGGAAAGTAAGAAACCTAAGAAGAAATTAGATGAGCAAGTAGTCAATAAGTTAGTAGAAGGAATAGCTCCAGCAATACCTATTGCCAAGGGTAAAATACCTCAGTTAGCAGGTGGACTAGAACAGGTAAATGGTGGACTAAAAGTTTTAGAGAGTATGGCATCAAGTCCAGAACAAAAACAGATTATGCAAGGACTAATAAATAATATAGAACGAGATAAAGAAGATATTAATAGTTTACTTGAAGCTTTCAAGCTAATAGAAACTGGAGAAGATGGAAAAGTTAAATATGGACTTTTACAACTTTCAAAACTTCTTGTTAGGAAAGACATTGATGGAGAGTATTGTGTCATAAAGAATACAATAGATGATTTAAATAATGTTGAAAAGTTAGCAAAACAAATAGCTTCTGGCTATGGAGTCGATATTGAAGTTGTACCTGTAGAAAAGTTACCACCACAACTAATACCTCTAAAACAATTATATATGGGAGCTAATCAGATTTCTACAGAATTAAATAAAATATATTCAAATCCAAAACTTAAAGTATTAAAAGATGGATTAAATATGTATCAGGTAATGTATCAAATGGAGAGTTATGACAGAACAATAATACCTAAATTAACAGGAATTATTGACGGTCTTAATGCATTATATGAAGGTTCAAATAAGTTATATAACGGATTGGATACTTTATATGATAAGACAATAGGTCTACAAGATGGTATAGGACTTTTATATAATGGCTCTAAAGACTTAAATAACGGAGCTGATAAGTTCCAAGGTATAGTTCCAGTATTAGTAGGTGGAGTTTCTCAGCTAACAGATGGTACTAGAGATCTAAGTGATGGACTATTTAAATTAGAAAAAGGTACAGGCACTCTTTCAGATAAAGTTAAAGAATTAAATGAAAAAGTACCAGATATGCAAGATGGAATAAATCTACTTTATGATGGTACCTTTGATTTAACAGATGGTCTTTCAAAGTTGAAAGAGGCATCAGGAAAACTTAATAATGGTGTTTCAAACTTAAAAAATAAAATGCCAGATCTTCAAGATGGTGTGGATAAACTATATGAAGGATCTAGTACTTTAAATTCAAGTCTTGCTAAGGGAGGAGAAAAGATATCAGATAGGTTAGTGAGAAGCAGTAAACTTATGGGAGATTTTGTTTCTAATCCTATAAACTTAGATGATACTCCAATATTTGATGTAGATAAGTATGGTATTGGACTTGCACCAAACTTTGTATCTCTTGGATTATGGATGGGAGCTCTTATGATGTTCTTCCTAATTACAGATAAAGTTCAAGAAGAAAAAGTTGGAAAAGCTAGAAATGCTTCTATAATGTTAGGAAAGTACCTATTATGTGGTGCTATTGGAACTATTCAAGCAATATTATTAAGCTTGGCTGTTATAAAATTAGGGCTAAACCCTGTAAGTAATTTAACCTATATAGGATTTAATATATTCCTATCTTGGGTATTTGTAGCAGTGGCTATAACATTAGTATTCTTACTTGGAGACGTTGGAAGACTATTACTTGTTATAATCTTACTATTACAGTTAACATCTTCAGGTGGAACATTCCCAAGGGAATTGTTACCAAAGTTCTTCCAAGTAGTAAATCCATATTTACCATTTACTTATTCAATATCAGGAATGAGAGAGGTAATTTTAGGACCAAATCCAGCGGTTTTAAGAAGAGATATTGCAGTATTAACAGCTGTATTAGTTGGATCCCTAGCTATAGGTATGGCTTTTAAAGGACGTATGGATGATTTCAAAAGAAAAAAATCACAAGAAAAAAATCAAATTATAGATGAAGGAAGCAGTATAAGTCATTAAAATTAATACCAGTTATAACATTCTTTATAAGATTGCTTATAACTGGTATTTGAATAAAATCGTACTTTATAAGAGAGGTGAAGGGCTAAAAGCCAATTTCATGGGAAAGAAAAAAATAACTATAATATTATTAACAGCTTTTTTGACAACTATAGTAGTTCCAGCATTTGGAGTTACAATGCAGGGAAATAATTTTATAAATTCTAAAGTACATGCTTATGAAAATAAGGATACAGAGGATTATGATTTAGAAGAGGGAATAAAATTTCCAGATAAAGAACTAGAAAAGGTTATAAGAGAACAAATCAATAAACCAGTGGGGGCTATAGAAAAAAGTGATTTATCCAATATATCAGAATTGGATATAAGAAATAAAGCAATAAAGAGTATAGAAGGGGTTCAATACCTTACTGGTCTTCAAACTATTGATGCAGCAAATAACAAAATTTGCGACCTGTCCCCCATAAGTGATTGTACATCTCTTAGTAAAATAAACTTTTCTTATAATAAAATAGAGGATATATCACCACTTAAAAATTTAACTATTTTAGAGAAGGTTTATTTAAAGGACAATGAAATTAAGAAAGTAGATGCCCTAGAAGATTTAAGAGAGATGAAGGAATTAGATTTAAGTAGTAATGAAATAAAGAATTTAAAACCACTAACTTATTTAAGTAATCTTAAGACCTTGACTATGGCTGATAATGGATTAAAGGATATAGATGATTTAGGATCTTTAGAAAAGCTTGAAAGTTTAACTCTTAGTAAAAATAATATTTCTGATATAAGTGCTATAAAGGTTATAAGAAATTTAACTAAGCTATATATAGATGATAATCAAGTAGAAGATGTATATCCTCTTGTAGGAATGGATTATTTAGAGAGAATAAATTTAGATAAGAATAAGATAAAGAATATAGGAGAGTTGGAAGCGAACAAAGATAATTTAAAGTGGGTTAAATATAGAGGAAAAGAAATTACAGATATAGGTACTTTAAAATATATAGTTGAACAAGCAAATGTGGTAGTTAATTTTAAAGATAGAAATTTAGAAAGAGAAGTAAGAAAGAAAATAGAAAAGCCTTTAGGAGAATTAAGGCTTGCAGATGTTGAATATATAAAGGACTTAAATTTATTTGCTAAGAATATAAAAGATATTTCAGGAATGGAATACTTAAGAGGATTGAGATGGGTAAACCTGGGTAAAAATAATATAAGTGATATAAGCCCATTAAAGGATTTAGAGGATTTGGAAGGTTTATATCTTTATAAGACCAAGGTTTCAGATATAACTCCATTACAAGGATTAGAAAACCTTAAGAAACTGCAAATTACATCTACGAATTTATCAGAACTACATCCTCTTAAAAACTTAACTAATTTAGAAAGACTTGAGTTAGGAGAAAATAAAATATTTGAAGTAGATGATTTACAAGGGCTTATTAAATTAGAAGTATTAGATTTAAGTGATAACTATATAAAAGATATATCTTCTTTAAAAAATCTAACGGATATAAAGGAACTTAAACTTAATAAAAATAAAGTAAGTGATATAAGTATTGTAGCAAACATGAAAGATCTTCAAAGGTTATATATAAATGATAACAATTTAACTACTTTAAAACATCTTAAAGATGCAAAAGATCTTGTATGGCTTACTGCAAACAACAATAAAATAACTAGTCTTGAGGGGTTAGAGGATCTTATAGATATTAAAGAAATACATGTGGATAATAATAAAATAGCTAAATTAGATCCACTTAAAAACTTAAAAGAATTAGAAACCCTAAGTGCTAGAACTAATGTAATATCTGACTTAAAGCCAATAGAAAACTTAGATTATATTAAGAATCTTTACTTATATGAAAATAAGATATCTGATATAAGTCCGTTAAAGAATATGACAGGAATGTTAAGATTATATTTAGATAAAAATAATATTAAAGATATTTCTGTAGTAGCTAATATGAAAGATGTTACTACTTTAAGCCTAGGAGATAATAACATCATTAATCTAGCTCCAGTTGCTGGATTAGAGGATCTTGGTACTCTAGATATCGGAGATAATGACATAAAAGATATAACAGTTCTTTATAATCTACCATCTCTAGAGAAATTAGTTGTGACTAATAATGATAATTTACCAAAACATCAAATAAATGCTCTTTCAAAAGACGTGAAGGTAGTTTATTAAGACTATCTGTGTAATTTAGTGTATTAACTAACGGAGGTGAAACTGGTTAAATACCAGAAAGCATATGAATAAGAAAAAAATTACTATAGTAACTGCTGTAGCTTTAACTTGTGCTCTTAGTTTCTCTGTTTTAGCTTCCTATCCTAATGAAGATAAGGCTTCAAGTAAAGGTGGAGTAAGAAGAGTTTTTGCTTCAGCAAGTTTAAACGAAAACAATATAAAGTTTCCAGATAAAAACCTGGATATTGCTATAAGAGAGGCTACAAATAAAGAGCCTGACGCAACTCTTACTAAAAATGATTTTAAAATGGTAACCAAGCTTAATTTAAAAAGTAAAAATATAAAAGATATTTCAGGATTAGAGTTTTTTGAAAACCTTCAAAGTTTAGATTTAAGTAATAACGAGATAAAAGATTTAGAGCCTTTAAGTGGTTTGAAATATTTAAAAGAACTAACCCTATATAAAAACAAAATAACAGAGGTAAAAGCTTTAGATGGCTTAAAGAATTTAGAAAAGCTTAATCTAAGAGATAATAAAGTTAAGAATATAGAAGGATTAAAAGGGTTAGAAAAATTAAGAGAATTAGATCTAGGTAAAAATTCTGTATTTCAACCAAAGCCCCTTAAGGATTTGAAGAATTTAAGAATACTTAATTTAGAAAGTAATGGTATAGGCAATGCAGAGGATTTAGAAGAATTAAAGCAAGTAGAACATTTAATTTTAAGCAATAATACTGTTGATGATGTGGAACCACTACTTACATTAACTAATGTAAATAAGCTTTATTTAGATGATAATCCAGTTACACATGTAGGAAAACTTAAAGACATGCCAAATCTAAAGAGACTTAATATAAACAACGATAGTATAGAGGATTTAGCAGAACTTAAAAAGTTTAAAAATCTTCAGTGGCTAAAGTTTAAAAATCAGGAAATGGTATTAGATAATAAGAAATTAAATGATTTATTAGTGGATTCAAATAAAGAAGTTAAATTTGCAGACAAGAATTTAGAGTTTGCTATAAGGGATAAAATAGAGAAACCAAAGGGAGCAATAAAGAAGGCGGATTTACAAAGGGTAACTCAATTAGATTTATGGGATAAAAATGTAACAAATCTAGCAGGTATAGAAAATCTAATAGATTTAAGGGTTTTAAATGCTGGTAAAAACAATATAAGTAATTTAGAACCATTAAAATCTATGGACAACCTAGAAAATTTATATTTAACTAAAACTAAGGTTATAAGTCTTGAACCTTTAAGAGGATTAACTAATTTAAAAGCATTAGTTATAAATGAAACAAGTGTATCTGATTTAACTCCTATTAAGAATTTAATTAATTTAGAAAGACTTACACTAGGAGATAATAAATTAGTATCCCTAGCGGGAATAGAGAATTTAGTTAACTTAGAATCTCTAGATATAAACAAAAACAATGTAAGTAATTTAGCTTCAATTAGAGGTTTAACTAACTTAAAGTCATTAAATATTAATGAAAACAATGTAACAGACTTAAGTATAGTTACAAACTTAAAGAATTTAGAAAGAGTTTCTTTAAATAAAAATGGAGTGACTAGCCTAGGAGCCTTAGCGGCATTACCGGAGCTTGAATGGATTACAGCTAAGGAAAATGGACTAACAAGCACTGTAGGATTACAAAATGCATTAAAGCTTAAAGAGCTATTCTTAGATAGTAACCAAATATCTGATTTATCATCTTTAGCTAATTTAACATCTTTAGAAACTTTAAGTTTAAGGACAAATAATATAAGTGATTTAGGTTCTCTAAGTGATTTAACAAGAATGAAGAATTTATATTTGCATAAAAACAATATAGGAAGTATTGCTCCACTTGCAGGTATGGAAAATTTAACAAGACTTTATGTTGGCAAGAATCATATTTCAGATATAAGTGCAGTGGCAAACATGAAGAATCTTAAAACACTATCTATTGGAGAGAATATGGTATTCAATATAGGACCTGTATCAGGATTACAAAGCTTAGAGACTCTTGATGTAGCAGATAACTTTATTACAGACGCTAGTCCAGCTATAGGATTACCTAATCTTAAGGATATAATGCTTCTAAATACTAAAGTTCCAGAAGCTCAAATAAATGCGTTTCCAGACAGCGTAACAGTGACCAAATAGGCGACAAATAGGGGACGGTTAATAAAAACTAAACCTCAAAAGCAGGAATTGCTTTTGGGGTTTAATTTTTTCTAAGAAAGAAGAAGGGGGAGAAAGGGGGACGGTTAATAAAACTTTAAAGACAAAAAATAAGAACAATCCCAAGGATTTTATATTTACGAAACAACAAGTTAATAAATAAATTTAAAAACTGAAAAGCTTGTCCATTAAAAAATTAATATGTATTATTTAAAAAAGAAAATAAATTAAATTAGAGAAAGTAATAAAGTAACAAAAATTAATAAATTAGATATATGCATTATATATAAATCAAGAGGCTAAGTTGAATATATTTCTACAAAATTATTTATAATACGCCTAAAATTTTTATCTTCATCAATAGCATTAATAGCCAGTTTACACATATTAGATACAGTAGATTGAGTAATGTTTCCAATTGACTTACATATATCTGCACATGTAAAATCACAAAATCCTCGCATTAGAAGAACAGCTAGGGCTCTTGATTTTAGGATACTTCTATTATTTTTAATATAAAGTTTAACTTTATCTGTTTTAGTTTGCTTTGATATAAAGTCTATTACATCTTCTGGAGTGCAATCCCTAATTATTGATTTTCTTTCGCTGGTATAAATAGTTTTTTCATTTTGAAATTTAAAAGATTTAATTGATTCTTCATCATTAGACATACATATAAGTCTGATATAGTTTTTTCGAGCTGCTTCTAAATTATTTCCTAAAAATTGCATTATATAATTTTCATCTAATATTTTAAAAGGGTCTTTTTTAAGTCCTAGATATACTGCTAAGCTTGAAAATCTATATTTCTCTGGATGCTTAGAATATTTTTGTATATCTACAGGATTATTATGTATATAAGCAGAAGCAGTAATTAAATATTTTTGACTATCAATTATCTTGCTTTTAAACCTATCTTGAAAAAGGTGACCACGTCTTTTATATCTTTTATTAAAATTTAGGGAATATTTTAGATTAAGACCATGCATAATCTTTGATATATCAGCACCATTGGCATCTATTATGAAATGCCCATGGTTACTCATAAGACAATAGGCGTAGACTTTAAAATTAAAGATTTCTTTATAAAGCTTCACAAAATTTAAGTATTGTATTTTATCGAAGTCAGTTTGAAAAAGATTTACTTCACTTATACTCCTTACCATTATATGAAATATTGAGTTATCAGTTTTTACTCTTGCAGATCTAGGCAATAAAAACACATCCTTTGATATATTATTTTCTAAAATTATTACCAAAGCATGTGTTTTTATTCAATTATGAGGATTTTTATTTAAATTAATTAACCGTCCCTAGTTTTCCTTTTATAGGATTTCATAACTACTCATTATTACAGGCATATTTAAAGTATTTAAAACTCTTTCTAAAAGTACACCTTCTCTATTTGGATATTTAAATCCATAGCTCGCTTTTATGCAGGTAGTTATAAATTGGGTACTTCTATCTAGGGCTATAGGAAGGCTGTCTCCTTGGAGAAGACTTCCTGTAAGTACACTGGTAAATATATCTCCAGTACCAGGATAAGATGCAGGAATATATTTACAACCTATTTTCCAGAACATATCATCTTCTTTATTATAAGCCATTACGTTGGTGCATTGGTTGTGATTAATATCTGGTACACTTGTTATTATTACTATTTTAGGCCCATTATCGGAAAGCTTTCTAAGCCAATCTTTTATAGTGCACTCATTTATATCATCATCTATATTTTTATCTAAAAGGTATGCAGCTTCAGTAAAATTAGGTGTTATTATATCAGCTTTTTTGATAAGTTTCCTCATATTTTCTACCATCTTACCACCCATAGTAGAATAAAGTCTTCCATTATCACCCATGACAGGATCTATAACTTTCAAGTTATTTTTATTTCCAAATATGTCTATAAACTCTGATACTATTTCTATTTGCTGTGAAGATCCCAAAAATCCACTATATATGCAATCAAACTCTAAATTTAAACTTTTCCAATGGTTCATGAAATCTATCATGGAGTTTGTTAAGTCTAGAAAAGTATAATCCTGAAATTCACCAGTGTGAGTTGAAAGTATAGCTGTAGGCATAGGACATACCTGAAAACCCATGGTAGATAGTATAGGTATTACAGTTGTAAGAGAAGCCCTACCAAAGCCAGACAGATCATGAATAGCTGCAATTTTTTTTACGGGTTGTGTCATATTTATCATCCCTCCTATTTCAACCTATAGGTGTGAAAACCTTTATAGTTTAAAATTTCTATATTATTATCTTCTTTTAATCTAAGAAAAAGATTTTGAATATCTTCTTCATTTACTCCTCTTATTGATAAAAATCCTTTTAGCTCATGTTGATTCATTGGATGTCTTTTTATTATACTTAGTATAGCTTGATAATTATCTTTTGTTTCACTGATAAAATTTCCATTACTAAGCATATCGATAGAAATTCCATCTAAAAGATCTACAGCAAAATCTATAGTTTCTTTAGATGCAGGTTTTACCCAGGATTCAGCGGGAGGTCTTACGGCGGTATTAATATATATTTTTGAATAATTTATGTTTTTTATAAGTTCTTTTAATTTTATTAAATCTTTTTTAGAGCTATTTATATTTTCGATAAGCATTACCTCAAGCCATAGTTCTCCTTTGAATTTCTTTGAAAATTCTACTAGACCATCATAACTTTGTTGAAAATCTAGTTTTCCATAGGGTCGGTGAAGAGATCTAAAGGATTCTTCACTAAAAAAATCCATGGATGGTAAAACTATATCAGCATTCAAGAGTTCTTCTTGTACATTTTTATCATATAATAGTCCTGTATTAGTTATAACTGCAATTGGTTTATCAGTAAGCTTTTTTAATGAACTTATAAGTTTACCTAATTTACTGTATAGAGTAGGTTCTCCTTCTCCAACTATTGATATTACGTCAAAATCTTTATCATAAGAAATATACTTTTTAAACTCATTTATTATATCTTCTAAGGGAAAGAATTCCCTTCTAGTATTTGTAAGATTATGAGTTAAACCTATTTGACAATATATGCAAGAGTAATTACAAAACTTTTTTGGGATGGGACTTACCCCTAAAGATAGTCCCAATCTTCTAGATGGAATAGGACCGTAAATATATTTAAAATTATCCACAATATTCACCTCTTAGTTAACTTTTTCTTAACTTTCTATAAAAGCTATTTTTAAAACTCTAACTTTGATGTAGAATTATATAGTACCACGCATAGGTTATAGGATAGAGTTTATAACCTAATTTATTTCAATGTAGGTACTATAAATATTATTTCACAATATTTTAAATACTTCAAATGTATTGGTACACTTAATAAGTTTTGCATAAAGAGAACAGTTTTAAATAGGAGGAAATTATATGGAAAATAAAATTAAAGGATTTAATAAAAAAATTGTTGCATTAATTATGATAGCATCAATATCTGTAGCAGGAATAGGATGTTCAAGTAAAAAAGGAGAAGCTTCTTCCAATAAAGATAATAAAACTAAAAAAGAAGAAAGTGTTAAAAAAGATGTGGAGGTAAAAGAAAAGGAAGATCCAAAGAATAAAATAGAGAAGGATGAGAAGTTAACTAACAAAATAAAGAAAGAAAAGATAGTTTCAAACGGAGATGTATATGAACAAGGGGAATATGTATATGCTACTCTTATAATAAAAGAAGATGCTAAAAAAGAAGAAATAGATAAAGTAGCTAATGAGTATGCAAAAAAGCTAAAATCAGAACATAAAGATAAAAAAGTAAGTGTTCAAGCAGTTCAAGGTGGGAAAAACGTAGCAGATATAACTTTGAAGTAAGAAAATTAGGGTAAAAAGGGGAAAAATTAGGGGACAGTTAATAAAAATGACTAAAATACCAAGGGGGATACTCTTGGTATTTTTTCGCAAAAACAAATAAATGATAGAGGTAGAGGAGTAATAGAGGAGTAATAGGGGAGTAATAGGGGACAGTTAATGAAAAAATACGAAAATAAGCAAATTAGATGGAGAGATAATAATGAATATAAGTAAAAAATACAAAAAGATTTTTAAATATATTTTAGTAATAATTTGGATGGTTATAATATTTAAATTTTCATCAGATCCTGGAGAAATATCAGATGGTAAAAGTGGACTTATTGTAGAAGTTATAAACAATTTGGGGATAAATGTGAGCAGTACACTAGGAGAGTGTGCTAATTTTATCATAAGGAAAACGGCACATATGGGAGAATATTTTATATTAACTCTCCTTTTAATATCAGCTTTAAAAGAGGACTTTAATTGGAAAAAAACTTGCTGGCTAGGCATTTTAATAACTTTTTTATATGCATGTAGTGATGAAATACATCAAAGATTTGTACCAGGAAGATGTGGACAATTTTCTGATGTATTAATTGATTTATTTGGAGGGATATTAGCTATTTTTATAGTTAAGGTTTTTAATAATTTTAAAAAGCAAAAATAGGGGATAGTTAATAAAATAGGGGACGGTTAATAAAAATAAGTAAAGATTTGAAAATAAAATTTAGAAATAAAACCAAAAACTTAGAATAACAAAAAGAGAATTTAGATGGGAACTTAATGAAAATTCTTAAAAGAAAGTGCAAATTTTAATTAACCGTCCCCATAACTTCCTAACTTCTCTTTAAAATAAAAATAAAAATGGAGATGATAGTTCATGAAATACGGCATAAGAGCAGATAATTTGTATTTAGAAAATGTAATTTTGCAAGATGGTTTAGTGATAATAGATGATGATAGAATAGAAAAGGTTGTTTGCTATAATGAAATTGAAATATTGGATAGTAAATTGGAAAAGGTATATAATTTAAGTAACAAGAAAATATTACCAGGTATTATAGACACGCATATTCATGGTGGAGATGGATATGATACTATGAATGGAAATTTTGAAGCTTTAAATGGAATATCTAAATACTTAGTATCAAGAGGAATCACGGCATTTTTGCCTACAGTGGTAACAGATCATATGGAAAAAATAAAAATAGCATTAAAAAATGTTAAAGATAGCATGGGAAAGGTTCAAGGAGCTGAAATAATAGGATCCTATTTAGAAGGACCATTTATAAGCAAAGAGTTTAAAGGTTCACATGCAGAGAATTTAATAAGGAAAATTAGTATAGAAGATTTTAAAGAATTAATTTATATGTCAGAAAATACTATAAAAATAGTAGTATTATCTCCAGAAAAAAAGGGAGCAGAGGAGTTTATAAAATTTTGTAAAGAAAAAGGAATAATTGTAGCATTAGGACATAGTAATGCCACCTATGAAGAAACCATAAAAGCTATAGAAAATGGTGCAAAGGTAGGAGTTCATACTTTTAATGGAATGAGAAGTATACATCATAGAGAACCTGGTATAGTCGGGGCAATACTTACATGTGATAAAGTATATTCTGAAATAATTTGTGATTTCATACACCAACATCCAACTACAATTGATATATCATTAAGATGTAAACCAAAAGATAAAATAGTTCTAATTAGTGATTCCATAGAGGCGGCAGGATTAAAAGATGGAGAATATAAGTTAGGAGCATCAAAAGTAAATGTAAAGGATTCTATAGCAAGAATAGATAATGGTGCTTTAGCAGGAAGTACAATAGACATATTAAAATCAATCAAAATAATGATAGAAAAATTAAATGTAGACTGTTTAGATGCAGTAAATATGGCATCTATTAACCCAAGTAGAGAATTGGGTATTGATAAGTGGGTTGGAAGCATAGAACAAGGTAAAAAAGCAAATTTAACTATAGTTGATATGGAGTATAATCCATATATGACTATAGTTAACGGGAAAGTGGTGTGGAAAAGATAATATAATAAAAATTATATAACAAAAAAAGGGGGAGAAAAATGAATAAAAAAAGAACATTTTTAAACTTACTTGCAACTATAACTACTTCAGTATTTTTATCAGGCGTATGTGTAGAATCAAAAGTATCAGCTGCTACTTACTCAAAAAGTGAAAGAATTTGGGGGAAAGATAGATATGAAACAGCAGTAAAGATATCACAAAATGGGTGGAAAGACGGTGCAAACTGTGTAATATTATCCTCTGGTGAAGGATATGCAGACGCATTATGTGCAGCTCCATTAGCTAAAATCAAAGATGGGCCTATACTTCTTACAAAAAAAGACACATTAGATTCAAATACTTTAGAAGAATTAAAAAGACTTGGAGTTAATAGAGTATATATTGTAGGGGGACAAGGCTCTGTTTCAAAAGAAGTAGAGAACAAAATAAAGTCTGAAACAAATTCAAAAGTAGAAAGAATAGAAGGAAAAGATAGGTATGAAACGTCCATAAAAATTGCAGAAAAATTGGGGACGGTTAATAAAAATAACCAACCCAAAGAACTAATATTAGCTTCAGGAGAAAATTATGCAGATGCTTTATCAGCAGCACCAGTTGGAGCTATAAGAGAGATTCCTATTATACTTACAAAATCAAGTGAACTTCCAAGTGAAACAAAAGAATATATAAAAAAGTGTAATGCAAATAAAAGCTACGTAATAGGAGGACAAGCTTCTATTAGTGATTCTATAAAAAAATCATTACCAAGAAGTAAAAGAATATATGGTAAAGATAGATTTCAAACTAATGTAGCTGTAGCAAAGGCATTTCCATCTGATTTTGAATTTAAAAAACCTTATGTAGCTCTAGGAGCAGGTTCTACGGGAAACGAATTTGCAGATGCACTTGCAGTATCAGCTTTAGCAGCTAAAAATTCAGCACCAGTAATTTTAACAGGAAAAAACTTAAGTGATTCAACAGAAACTTTAGCTAAAGAAAACTTTTTACCTTCAAGTAAAATTACAGTTTTAGGTGGAATTAATAATGTACCAGAAAAGATAGTACAGGACATAAGAGCTGTAGCAGAACTTATGAATGAAGAAGAGGGTTTATATGATCAAAATATAGAAGGAAGTGCAGTAATTACTGCAAAAGATGTAACAGTTAATCATATAACGATAAATGGAGATCTATATATAGAAGAAAAGGATGCAGAAATAGTAAAAGTAAAAGTAAATGGAACAATATTTATAAATCCAGGTGAAAATGGAGAATGTAAATTAGAAGATGTAGAAGCAGATAAAGTAGTAATATTATCAGGAACAGAAAGAGGAATTTTCTTTAAAGATGTTAGAGCAAATGAGTTAGAACTAAGAAATAAAAATAAAACAAGAGTTGTACTAGAAGAATTATCAAAATTTAATAAAACAGAAGTGTTAACAGCAACAATTCTTCAAAATGTGGTAGGTTCCTTTGGAGAAGTTACTATAAAGGATACATTAAAAGATAAAGATGTAGAACTTCATGGATCATTTCATGAAAAAATAGTATTAGAAGGATCGGTTACCTTAAATGCATTTCCAGCAAATTATATAGAAAAAATAGAAGTAAAAACAGAGAAAGGTGAAGATATAATGTTGGATGGAGATTGTAGGGAAGTAGAAGTATATAGTGGAGTTAATATAAAGGTTACAAAAAACACTAAAGGAGACATAATAGCTAAAAGCTTAGAAGCAGAAAACTGTGCAACAATAGATATGCCTAAAAACTTAGATATAAAAGTGAAGAATTTTAAATTAGATAATATAACAGGAGAAGGTAAGGAACAGTTTATGTAAGTTCAGTTTATAAATAAAGAAGAATTATTAATTTTAAAATAGAAAAGGAGCTATCTTTTGCATTAATTAAAAAATCATTCCAAGAGAGCTCCTTTTATATCTAATTATATATAATCTATAAATTATCCGATATAATAAGTTCTATATTATTTTTATTAAAAAAGTCCAAATAATCATTACTAAGAGGTTCATTTGTAATAAATGTATCTATATCTTCTAAATTACAATAAGTCATTAAAGAAGCCATTCCTAACTTTGAACTATCTGCAAGTAAGATAATTTTAGAACTTTGTTTTACTACAGTTCTTTTTATTTCATATTCAAATGAAGAGGAATTAGTAACACCTTTTTTTATAGACACTCCTGTAGAAGCCATGAAACATTTAGATATATTATAATTTTTTAAAAAATTTATTGATTCTACTCCGATTAAAGAATTAGTATTTCTAGAAAGAGAACCTCCAGTTGACAATATATTTAGATTTTTATATGGAAATGAATTTACTATTACATTTACATTATTAGTTATTATATTTACATTTTTTTTATCGGATAAAAACGGAATCATATGCATAGTTGTAGTTCCAGAATCTATATATATTATGTCACCATTTTCCACTAAATTACTAGCGGCTTTAGCAATAATTTTTTTAGTTTCTTTGTATTTAATTTCTCTTTGTTGAAAAGGAACAGTGGATGTTTTATTTTTTAAGGTTATACCGCCATATATCTTTTTTATTACTCCCTTTCTTTCTAATTCTGAAATATCCCTTCGTATAGTATTTTTTGATACATCAAATAAAGAACATAAAGTGTTTATAGATACATTCTCATGTTTTATAACATAATTTTCTATTCCTTTTATTCTATCTTCCTTTAACATTAGAACCTCCACTAATAAAACATTAAAATAAATTTCATATGTAATTATATAATAATGAAATGAACATTACAAGCAAAGTTTTAAAATATAACCAAAAGTTAACCATAACATACAAATAAGAACATAAATTATTGACAGAATATTGATTAAATGATAAAATATAATCAAGAGTTAACCATAAGGTGGGAATATGTAATCATAAATGCATCAATATATACTATTGATTTGAAATGGAGGGGGACTAATGGCATATAAAATTAATATTCCTGGAAATATTATATATGGAAAGAATGCTCTGAAGGAATCATCAAAAAATATAAAAGAGCTAGGAGGAAAAGCTTTAATAGTTACTGATAAAATAATGGTTGAAATAGGTAATGTTAAAAAAGTCAGTGAAGTTCTTGATGATATTGGTATAAAATATGAAATATATGACGGAATTAATTCAGAACCTACAGATGTAATGGTAGATAAAGGAATAGAAATATATAATAATTCTCATTGTGATTTTTTAATTGCTATAGGAGGAGGAAGTCCTATAGATACTTCAAAGGCAATTGGAGCTATGGTAACAAATTTAGGAAATATAAATGACTACATGGGAAAAATAATAGAGAATGCCCCGCCAAGCATTGTAGCAATTCCAACAACTGCTGGAACAGGATCAGAAGCAACCGAATTTACAATCATATCAAATACAAAAGACAACATAAAAATGTTGCTAAAAGGAAAAAGTTTAATTCCTACTTTAGCAATAGTTGACCCGCAGTTTTCCATAACAGTACCCCAAAATATTACAGCAGCTACAGGAATAGATGCTTTGACGCATGCTATTGAATCATATACATCAAAACATGCAAATTCATTTTCAGATACCTTCGCACTATCAGCAGTAAAGCGTATTTTTAATAATTTAATAAAAGCATATAAAGATGGGAAGAATTTTGAAGCCAGAAATGAAATGGCTCTAGGTGCCTTAGAAGCAGGAATTGCTTTTAATAATTCTTCAGTAACTATAGTTCATGGAATGAGTAGACCAATTGGAGCTTTATTTAAAGTACCACATGGGCTTTCTAATGCAGTACTTTTACCCAAATGTTTAGAATTTGCAATTCAAGGGCAAGAAAAAAGATTTGCAGATATTGCAAAAGCAATAGAAATATGTAAAGAAGAAACATCAGATAAAGAAGCCGCAGAAAAACTTGTAAAAGAAATTGAAAGTTTGTGCAAAGATATTAATATACCAACCTTGGAGGAATGTGGTATAGAAAAAAATGAATTTTATGAAGAAATAAATAAGATGGCAGAAGATGCATTAAATAGTGGAAGCCCTGCAAATACTAGACGACAACCTACTAAAGAAGATATTGTTAATATATATAGACAGTTGTATATATAAAGAATTGAGAAGTTAAAGTTCTTATATTCCTAATATGGTTTTGAGAAAAAGGAGTAAATATCATGTCGATTGTAAAAATGAAACAACTTTTAAAAAACGCCAAAAAAGGTCAATATGGTATAGGGGCTTTTAGTATATCTAACATGGAAACCATTATTGGAGCTGTAAGAGCAGCTGAGGAGTTAAAATCTCCAATAATACTTCAAATTGCAGAATCTAGACTAAAGCATTCGCCCCTTTACTTAATAGGACCGGTAATGATTGAAGCAGCTAAAAAATCATCTGTTCCAATAGCAGTACATTTAGATCATGGCGAAAGCATTGATACCATAAAAGAAGCTTTAGATTTAGGTTTTACTTCTGTAATGTATGACGGTTCTCATTTTAATTTAAGTAAAAACATTGAAAGTACAAAAGAAGTTGTAAGTTTAGCTAAAGAATATGGAGCTTCTGTAGAAGGAGAAGTTGGAAAGGTTGGAAAAAAGGAAGATGGTTTAGGAGATGACACTATATCAATAACAACTGTTGAAGAAGCGGAAAAGTTTTATAAAGAGACAAATGTAGATGCTTTAGCTATAGCTATTGGAAATGTTCATGGTATGTATGTTGGGAAACCTAATCTTAACATCAAAAGGTTAATAGAGGTTAATAGTAATGTAGAAGTGCCTTTAGTTTTACATGGCGGATCAGGTATTACAAAAGAAGAGTTTAAAAATTGTATTAAAAACGGTATAACCAAAATAAATGTAGCCACAGCAACTTTTAATAGTGTGGTAGATAAGGTAAATGAATTATTTAAAACTTCTAGTTCAGTTGACTACTTTACTTATCATGATATTGTTATTGATGCAGCCTATGATAATGTAAAAAAACATATAGAGATATTTGGTAGTAGTAACAAAGCATAAATTTTAAGGAGGTATTTTAGTGAATTATATTAAGTTTGATGAAAAAAAACCACTAGATGTAATTCCTATTGGAAGAGTAACCATAGATTTTAATCCTAATGAGGTTAATAGACCTTTAGAAGAAAGTAGAACTTTTACTAAATACTTAGGAGGGTCCCCAGGAAATATAGCAGTTGGATTAGCAAGGCTTGGGAAAAGGATAGGTTTTTTAAGTACAGTATCTGATGATCAATTTGGAAATTTTGTAATAAGTTATTTAAAAAATGAAGGAATAGACATATCTCAAATAAATAGAGCTAAAAATGGGGAAAAATTAGGTCTTACATTTACGGAAATTTTAAGTCCTAAAGAAAGTAGTATATTAATGTATAGGAAAGGAGTAGCAGATTTACAGCTATCACCTAAAGAAGTAAGTGAGGACTATATAAAAAGTGCAAAAGCTATAGTTATATCTGGTACAGCTTTATCAAAAAGTCCATCAAGAGAAGCAGCTTTTGTTGCATTAGAATATGCTAAAAAACATAATACTAGGATAATATTTGATTTGGATTATAGAAAATATACATGGAATTGTAAGGAAGAAATAGCTATTTATTATTCATTAGCGGCAAGAATGAGTGACATTATAATGGGTTCAAGAGAAGAATTTAACCTTATGGAAGGGCTTATAAGTCCAGAGGGAAGTAATGATAAGGAAACAGCAGAAAGATGGATAGGATATGGAAATAAAATTGTTGTAATAAAGCATGGAAAAGATGGTTCAACTGCTTATTTACATGATGGTACAAGCTATAAAATAAAACCATTTCCAGTAAAACTCTTAAAATCCTTCGGTGGTGGAGATGCATATGCTTCAGCATTTATATATGGAATTATGGAAGGATGGAATGTTATAGATGCATTAGAATTTGGTAGTGCTTCAGCGGCTATGCTTGTAGCAAGTCACAGCTGTTCCGAGGCTATGCCTAAAGTGGAAGAAATTAAACAATTTATAAAAGAAAAAAAAGAAGAACATGGTGAGATGGTAGTAAGGGGGTAATAATTAATGCTTGAAAAACTTAAAGAGCTAGAGAAAGGGCATAATATTTTAGTAGAATCTAATGGAAAACATAGTGAAATGATGATGGATATAGGTATATGCAAATTAGAAACTGGACAGGAAGAGTTTTTTATAGAAAAAAACAAAGAAAGTTCATTTTTATTGCTTTTAGGTAAGATGGTAATTGAATGGGAAGATAAAGAACAGGAAATAGAAAGAAATTCTTTATTTGATGAGGACCCCTGGTGTTTACATGTACCCAAAAGTGTAAACGTTAAAATTACAGCTTTGACTGATGCGGAAGTGTTAGTTCAAAAAACAGAAAACTCTAGAGTTTTTCCATGTAAATTATATTCTCCAAAAGAGTGCAGAAGTGATGTATTTGGTCATGGAGTTTGGAATGACACAGCCAGAAGAGTTGTAAGAACAGTTTTTGACTATTCAAATGCACCTTATTCAAATATGGTAACGGGAGAAGTAATAACTTATCCAGGAAAATGGTCAAGTTATATTCCGCACCATCATCCACAACCAGAGGTGTATTATTACAGATTTAATAAACCTCAAGGATTTGGATGTGCATTTATAGGAGAAGAAGCTTATAAAATCACAGATAATTCTATAGCAACTATTCCAGGTGGATTAGTACACCCTCAAACATCTGCACCAGGTTATGCAATGTATTATTGTTGGATGATAAGACATTTAGAAAACAATCCTTGGACAGATAGGATTAATGAAAAAGAGCATGAGTGGCTTTTAGAATCAGATGTTAAGATTTGGCCTGAAAAATAGTAAAAGGAGGAATTATGGTGGAAACTATCAAGATGACAACTGCTCAAGCACTTATAAAATTCTTAAATCAACAATATGTAGAACTAGATGGACAGGAGTGTAGATTTGTAAGAGGAATTTTCACAATATTCGGACACGGAAATGTTTTAGGATTAGGACAAGCACTAGAGGAGGATCCAGGTCATTTAGAAGTTTATCAAGGACATAATGAACAAGGAATGGCCCAATCAGCTATAGCCTTTGCAAAACAAAGCTATAGAAAACAAATATATGCATGCACATCATCTATTGGACCAGGTGCTGCTAATATGGTAACAGCAGCAGCTACAGCTACAGCAAACAATATACCTGTATTGCTATTACCAGGGGATACTTTTTCAACAAGACAACCAGATCCAGTGCTTCAACAGGTAGAGCAAACATATAACTTATCTATTACTACTAATGATGCCTTTAAGGCAGTAAGTAAATATTGGGATAGAGTAAATAGACCTGAACAGCTTATGACAGCTATGATAAATGCTATGAGAGTATTAACAGATCCTGCAAATACAGGAGCGGTAACTATAGCATTACCTCAAGATGTGCAAGGAGAAGTTTATGATTTCCCAGAATATTTTTTTAAAAAGCGTGTTCATAGAATAGAGAGAACACCTCCTTCAAAACAAGCTATAGAAGATGCTGTAGAGCTTATAAAAAGAAAAAAGAAGCCATTAATAATATGTGGTGGTGGTGTTAGATATTCAGAAGCAGCAGAATCACTTAAAAGATTTTCAGAAGAGTTTAATATTCCTTTTGGAGAGACGCAAGCAGGTAAAAGTGCAATTGAGTGGAGTTATGAATTAAATCTAGGAGGAATAGGGGTAACTGGAAACTCTGCAGCTAATAGTATAGCAAAAGATGCAGACTTGATAATAGGTGTAGGAACTAGATTTACTGATTTTACAACTTGTTCAAAGTTTTTATTTCAAAATGAGGATGTAGAGTTTTTAACTATAAATATATCCAATTTCCATGCTAATAAATTAGATGCAGTAAAAGTTATTTCAGATGCAAAAGTAGGGCTAGATACAATAGCAAATGAATTGGAAAAGCAAGGATATACTTCAGCTTATAAAGATGAAATAAAAAAAGCTAAAAATGAGTGGAAAAAAGAACTTAATAGACTTTTTAATATAGAGTATACAAAAAGAGAGTTTGTACCTGAAATAGCAGGTCATTGTGATGAGGTAGTAGAGGAGTTTTATAAAGAATTTGATTCTTGTTTAACACAGACAAAAGTTTTGGGAGAACTAAATGAACTTTTAGATGATGATGCAATTGTAATAGGAGCTTCAGGAAGTTTACCAGGAGACCTACATAAAGTATGGTGTCCTAAAAAGAGTAATACTTATCATGTGGAATATGGATATTCTTGTATGGGGTATGAAGTTTCTGCTGCCTTAGGAGTTAAACTGGCAGAAGAAGATAAGGAGGTTTATTCCTTGGTAGGAGATGGAGCTTATTTAATGCTTCACTCTGAGCTAATTACTAGCATAAAGGAAGGAAAGAAAATAAATATATTGTTGTTTGATAATGCGGGTTTTGGATGTATAAATAATCTTCAAATGTCTAATGGTATGGGAAGTTTTGCTACTGAATTTAGACATAGAAATAATGAAACAGGAAAACTTGATGGAAAGCTTTTGAAAATTGATTTTGCAAAATCTGCTGAAGGATATGGGGTTAAAACTTATAAAGTAAATACAATAGATAAACTGAAGTACGCAATAGCAGATTCTAAAAAGCAAAAAATATCCACGTTAATTGATATAAAAATATTACCAAAAACTATGACTGGGGGATATGAATCCTGGTGGCATGTTGGAGTATCGGAAAAATCAAAAAGTCCCAAAATAAACAAAGCTTGTGAAAGTAAAATAAACCATTTAGCCAAAGCTAGAAAATATTAAATCAATAATAATTTAATTCAAAGATAAAAAGGGGATGAAGGTAATGATTAATTTAGGAGTTGTTGGATTTGGAAGAATAGGTAAAGTACATGCAGAAAGTTTAACTAAATATGTTTCTAATGTATCACTTAAAGCTGTTGCAGATCCATTTATGAATGAAGAAGGTATAAATTGTGCAAAATCCATGGGAGTTAAGAATGTATATAAAGATTATAAGGAGATATTAAATGATCCAGAAATAGATGCTGTGCTAGTATGTTCATCTACAGATACTCATTCAAAGATATCTATTGAGGCATTAAAATCAGGTAAACATGTATTTTGTGAAAAACCAATTGATCATGACATTGAAAGAATAAAAGAGGTATTAAAAGAAGTTGAAAAATCTAATCTTAAATTTCAGGTAGGGTTTAATAGAAGATTTGACCATAACTTTAAAACTATTAAGAATACTGTGGAAGCAGGTAAAATTGGAGAACCCCATATAATAAAAATAACATCAAGAGATCCAGAAGCACCTCCAATAGAATATGTAAAAGTTTCAGGCGGAATCTTTTTAGATATGAGCATACATGATTTTGATATGATTCGTTATCTATCTGGAAGTGAGGTAGAAGAAGTATATGCCATAGGGGATGCACTTATAAATCCAGATATAAAGAAGGAAGGGGATGTAGATACTGCAATAATAACATTAAAATTAGCAAATGGAGCTTTAGGTGTTATAGATAACAGCAGAGAGGCATCTTATGGCTACGATCAAAGAGCAGAAGTATTTGGTTCAAAAGGATCAGTTCAAATAAGTAATGATGCTAATTCTACAGCTGTGGTTAGTACAAAAGATGGTATAACTGGAGAAAAACCATTATATTTTTTCCTAGAAAGATATATGCAATCTTTTGCTGATGAAATAAAAGAATTTGTAAAAGCTATAGAAGAAGATAAGGAAGTTCCTGTAACGGCTATAGATGGACTTAATGCTGTATTAATAGGAATTGCTGCTACAAAATCATTAAAAGAGGGAAAAGCAGTTAAGATTTCTGAAATAGGTTTATAAGAAATCATATTAAAGGATTGGGGGAAAATTTATGTTTAATAAAGATAAAGTGAAAATTGGAATAGCGCCTATAGCATGGACTAATGATGATATGCCAGAACTTGGAGCAGAAAACACCTTTGAACAATGTATAAGTGAAATGGCATTGTCAGGTTTTAAAGGAACAGAAGTGGGAAATAAATACCCAAGGGATACTAAAGTTCTTAAAAAGGCTTTAGAACTTAGAGATATGCAAATTGCTAGTGCATGGTTTAGTGCTTTTTTAACTACAAAACCTTATGAAGAAACAGAAAAAGCTTTTATAAAACACAGGGATTTTCTTCATGAAATGGGAGCAGGGGTAATAGTTGTATCAGAACAAGGACATAGTATACAAGGGGAAATGGAAATACCTATATTTAAAGAAAAACCTATATTTACAGAAGAAGAGTGGAATAATTTAGCTAAAGGGTTAAATAAGCTTGGAAAACTAGCAAAAGAAAAAAATATGGAAGTAGTTTATCATCATCATATGGGAACGGGCGTTCAAACTACAGAAGAAATAGATAAACTGATGGAAATGACAGATCCCACACTTGTATATCTATTATATGATACTGGACATCTTGTATTTTCTGGAGAAGATCCTATAGCTGTTTTAAGAAAATATATAAATAGAATAAAGCATGTTCACTTGAAAGATATAAGAGAAGATATAGTAAAGACAGTAAAGCAAAAGAAGATGAGTTTTTTACAAGCTGTTAAATTAGGAGCATTTACTGTTCCAGGAGATGGAAATATAGACTTTAAACCCGTATTTGATATTTTAGCAGAGAATAATTATGAAGGATGGCTTTTAGTAGAAGCAGAGCAAGACCCTGCAAGAGCAAATCCACTTGAATATGCTATAAAAGCTAGAAAGTATATACAGGAAAAGGCAGCGATTTAATCAATATCTTACAGGTTTTAATGGAGGAAAATATGAATAAGATAAAGGTTGGTATTGTTGGTTTAGGAAGACTTGGAAGAAAACATGCAGAAAATATAGCTTTAAGAATATCTAATGCAGAGCTTACTGCGGTTTGTAGTGTGATAAAAGATGAAGTTGATGAAGCTTACAAAAAACTTAATGTTAAATATGGATATACGGATTTTGATGAAATGATTAAAAATAAAGAATTAGATGCTATATTTATATCATCGCCATCAGGATTTCATTGTTCACAAATAGAGAAAGCCCTAAAAGCAGGATTTCATGTATTTAGTGAAAAACCTCTTGGATTGTACTTAGAAGAAACTAAAAAACTAGCTAAAGTAGTTAATGAATATAGGGATAAACAGATATTTATGCTTGGATTTATGAGAAGATATGATAAATCCTACTTATATGCAAAGGAAAAGATAGAAGATGGGGAAATTGGTAAACCAATGCTTATAAGATGTTATGGATTAGATCCATCTTGTTCTATAGAAAGTTTCTTGAGTTTTGCTAAAAATAATTATAGTGGTGGGTTATTTTTAGATATGGCTATACATGATTTAGATCTTGCAAGATGGTATTTAAATTCAGAAGCTGAAAAGGTGTGGGCTATAGGAGATGCCTATGAGTATGAAGACTTTAAAAAAATTAATGATGCAGAAACAGGAGCAGCTCTAGTTAAATTTAAAAATGGAACAATAGGTATATTTGTGGCAGGAAGAAATTGTGCCCATGGATATCATATAGAAACAGAGATAATAGGTACGAAAGGTAGTTTAAGAATAGGAACCATACCAGAGAAGAATATGGTTACTGTATTTAATGATAAGGGGGCTATAAGAGAGTGTTATCAAGGATTCTTAGAAAGATTTGAACAAGCATATTTATCTGAAACAGAAGATTTTATAAATTGTATAATGGAAAAAAGACAACCTAAAATAACTGTAGAAGATGGCGTAAATTCAACAGCCTTAGCCTATGCATGTAAGGAATCCTTTGAAACTGGAAAGTTAATAGAATTAAAATAGTAGTTATAAAAAAAGGGCATATTACTTTCAAATATCACCATATGAAAGCAGTATGTCCTATAAAATAATATAAATGTTGAAAATTTATATAAACACTATACTCCATATTATAAATGTAAATTTAAAATTTGCAAATTAAACCTTTACCATATATAAAATAATGGGATTTTTAAGGGGGAGAATAAAGTTGAGTATAATAACGTGCATATCATTTATAGCTTTTACAGCCTTGGTTGCAGTTTTATCATGGTATAAAACTCGAAATGATGATTTATCTAGTCAGGATGGATATTTTCTTGCAGGTAGAAGTTTAACTGGAGTTTTTATAGGTGGATCTTTAATGCTGACTAATTTGTCTACAGAACAAATGGTAGGATTAAATGGACAAGGATATAAATATACAATGGCCGTAATGGCTTGGGAAGTAACTTCGGCTTTTGCTTTGGTACTTATGTCTCAAGTATTTTTACCTAGATATTTAAAAAGTGGAATAACAACTATACCAGATTTTTTAGAAGAAAGATATGATTCATGTACTCGTAGGATAATATCTATATTATTTTTAATTGGATATATGGCAGCTTATTTACCTACAGTATTATATTCAGGGGCTGTAGTTTTAAATAGTATATTTAATGTACCAGAAGTATTTGGAATTGGGCAAATGCAAGCTTTAATTGTGACAGTTTGGGCTATTGGAATAGTGGGTTCTATATATGCTATATTTGGTGGACTTAAAGCTGTTGCAGTATCAGATACTTACAATGGAGTGGGACTTTTAATTGGTGGATTTATGATTACTGTATTTGCATTAATTAAATTAGGTAGAGGAAGTTTGGGAGAGGGAGTTAACACATTGATTACAGTTCATCCTGAAAAACTAAATTCTATAGGAGGAGCTGATTCACCTGTTCCTTGGACCGTATTATTTACTGGAATGCTTTTTAATAATTTATTTTATTGGTGTACCAATCAATCTATAGTACAAAGAACTTTTGGAGCAAAAAACTTAGCGGAAGGACAAAAAGGTGTTCTTTTAGCAGGATTTTTCAAACTATTTGGGCCTTTATATTTAGTTTTGCCGGGGATTATTGCATTTCATTTATATGGAGGGTCACTGTCTAATCAAGATATGGCATATCCTACTTTGGTAGTAGATGTTTTACCAAAATCTTTAGCAGGATTCTTTGCAGCAGTTTTATTTGGAGCTATTTTAAGTTCCTTTAATAGTGCTTTAAACAGTTCAGTAACCTTATTTACTTTAGATATTTATAGACCAATATTTAAACCAAATTCTACAGATGAAGAACTAGTTCAAGTTGGCAAAAAGTTCGGGGCTATTTTAGCTATAGTATCAATGGTTATAGCACCGCTTATAATTAATGCACCATCAGGTTTATATAATTATTTGCAAGAATGTAATGGTTTTTATAATGTACCTATTTTGGCAGCTATTTTAGTTGGATTCTTCTCAAAGAAAGTTCCTTCGATAGCACCAAAAATAGCATTAGTATTTCATATTATACTTTATAGTATATCTAAGCTAGTTTGGGGACATGTCAACTTCTTACATGTATTAGGCTTTTTATTTCCAGCATGTGTAGTTATAATGCTTATAATAGGAAAAATCAAACCACGTGAAAATGATTATGTTCAAAAATATACTAAACAAGTTGATATAACACCTTGGAGTAAATCTAAATTAGCTTCAATAGTTATAAGTGTATTAATGATTTGTGTATATGTTTTATTTTCAAAGATAGGAATAGTAGGTAAGTAACATAAAAAGTCGGAATATTCTAAAGGATTAGGATATATCAAATAAAGTCCAGTGGAGTTGTTTCATTGGACTTTATTTGATATATAGAATTATAATTGATAATAGGAGCATTAAGGAAATGGAGGGATTTTAATTATAATTCTAGAATATTGTTATATATAATAGATTAAGGGATTATCAACTAAATCATAAAGGAGTGATTCCAATTGAAAAGAAATTTTATAATTACATTAATGGCATTCATGCTACTAACAGGTTTTGTTATATCAGAAAAGGTACATGCATCTAATATATCTCATGAAAGATATTGGGGAAAGGATAGGTATGAAACTTCTATAAAAATATCTGAGAAAGGTTGGCAAAATCAAGCTAAATATGTGGTTCTAGCATCGGGACAAGGTTATGCTGATGCCTTATCTGCATCACCCTTTGCAAAGCTTATAGATGCACCCATACTACTTACCAAGGGAGATAAATTAGAGGAGAAAACCTTACAAGAAATAAAAAGATTAAATCCATCAAAAGTTTATATAATAGGGGGCGAAGGTTCTATATCACAACATATTGAAGATGAAATAAAATCTAAGATAAGTAATGATGTGGAAAGATTTAAAGGTGAAGATAGATATGAGACCTCTATGAAAATTGCACAAAGATTTCCTAACAAAGAAAAGGTGATATTAGCCTCTGGAGAAGGATATGCTGATGCTTTATCTGCGGCACCTATAGCTGCTATAAACAGTATGCCTATTATATTAACTCCTAGGGACAGGTTACCTAAATTAGCAGAAGATTATCTAAAAAAAGATGAAGTTAAAACTATTTATATAATAGGAGGAACTGCATCTATAAGTGACACAATTGAAAAAGAACTTCCATCATCTATTAGAATTTATGGAAAAGATAGATTCCAAACCAATGCAGAAATAATAAGAAATTTCCCATTAGATTTTGATTATAAAAATGTATATATAACACTAGGAGCAGGAGAAACAGGCAATGAGTTTGCCGATGCTTTAACTGGAGCAGTTGTTGCAGCTAGGGACAGAGCACCTGTTTTATTAACAGGAAAAAACTTAAATAGTAATACAAAAGCTATATCAAATGAAGTGTTATTTCCACATACTAAGTTTAAAGTATTAGGTGGAGTTAATAATGTATCAGATAAGCTAGTAGAGGATATAAAGGTTACAATAACGGATAATTTTTTAAATAAAGATAAGGAATATACTAGAAATACCCTTGGAAATGCTATGATTTCAGAAGGTGGTATAAAGTTGAAGAATAGTAAAATTAAAGGTAACTTATATGTAGAAAGCGATGATGTGTCCCTAAAAAATGTAGAGGTTAACGGAACTATATATCTTGACCCAGGAAGAAAAGGACAGACTAGATTAGAAAAGGTGAAGGCTGATAAAATCATAGTTTTATCGGCAAGAAATGAAGGGAATGGGATTTATTTAGAAGATGTAGATGCAAATTTACTAGAAATTAAAAGTGGAACAAAGGCAAAGATAAGCATAAGAAGAGGGACGGATCTCAAAAAAATTAAAGTTTTAGCTAATACTTTAATTGAAAATTATCAAGGTGATTATAAAGAAATAATTATTCCTAAAACTCCAAACTATAAAGAACTTGAGTTAACAGGAAGCTTTACTGAAAATATAATAGTAGAAGGTCAAACTGAGCTTAAAACTATAGATGGAGCATATGTTACAGATGTTTTAATAAAGACAGATAAAGAAGATGTAGTTATATTAGATGGAAAGTTTGATGATGTAAAAGTTTATACAGCAGCAGATATAAAAATTACAGAAAAAGCTTCTGCTAGAATATTTGGAGAAACTATTGAAGCACAAACAAAAGCTGAAATTTATGTTCCTAAGGGGGCAGATGTTAATATAAGAAGAATTAGACCGCATAATATAACTGGAGATGGAAAAAATAATGCATTAAATTAAATAAAAACCGATTGGTTTTAAATAGCCATCGGTTTTTATTATGTATGTGAGAGTTATATGTAGTAAAAGGTTATGATAATTCATATATTTTAACTATAAATGAAATTTATTACTAATTATTGGGGAGCGATATTATACAAAAGTGATAAAATGTATTAAAATAGTATTTATAGAATGTAAAGTAAAATTTAAGATATATATGTAAAAATGTATTTATATTTTTAATTGAGATGAGGGGGAGGAATATAAGATGTGTAAAAAGGTAAAAAATTTTTATCTATTTGTATTGCCACAATGCTAAGTTTAGCAACTGCTATAACAACTACAAAAACATCAGCAGCGGAATTGGCTAAAATTACAAGAATCTGTGGAGTAGATAGATACCAAACAGCTGTGAAAATATCGCAAAATGGGTGGAAATCAGGATCAGATTACGCAATACTAGCATCAGGAGAAGATTATGCTGATGCTCTATGTGCAACTTCACTAGCAAAAGCTAAAGATGCTCCTATATTTCTTACAAAGAAGAATTCATTAAATGAAGAAACTTTAAAAGAACTAAAAAGGTTAGGAGCAAAAAAGGTTTATATCATAGGTGGAGATGGTTCTATATCAGAGGAAATGGAAAATGAAGTTAAATCAGTAGTAAAAAATACTGAAAGACTACAAGGAAAAGACAGATATGAGACTTCAGTTAAAATTGCAGAAAAATTAGGGGAAAGTAATAAAGTTATATTAACATCAGGAGAAGGCTATGCAGATGCTTTATCAATAGCACCAGTTGCAGCAATAAAAGGAATTCCAGTAGTTTTAACAAAGGTTAGAGAACTACCAACATCTACAAAAGAATATATAAAATCTATAGGTGCAACAACAACTTATGTAATAGGTGGAACTGCAGCTATTAGTGATACAGTAAAAAATTTAGTACCAAGTCCAGAAAGAATATATGGACAAGATAGATTTGAAACTAATTCAGAAATTATAAAAGCTTTTGCCATAGAATTTGATTTTGAAAACGCATACGTGGCATTAGGGCTAGGTTCTACAGGAAAAGAATTTGCAGACGGTCTATCAGCTTCAGCCCTATCAGCTAAAAATAGAGCACCAGTAATTTTAACTGGACAAACTTTAAATAGCGTAACAAGAGATTTAGCAAGAGAAAAACTTTATCCAACAACTAATTTAACAGTTTTAGGTGGAGTTAAAAATATTTCAGATACAGCTGTAGGTGAAATGAAAGTAACAGGTGAAATTATAAAAACTGAAAAGGAGCTTGAAGATAAAAATATAGATGGAAACTTAGCAATTACAGTTAAGAATGCAGAGTTAAGAGATAGCAAAATAAAGGGAAATTTATATATTGAAAATGATAATATATTATTATCAAATGTAAAAGTAGATGGAACTATTTATATTAATCCTAGAAGTGAAAATACATGTAAATTAGAAAATGTAATGGCCAATAAAATAATAGTATTATCAGGTAGAGAAGAGGGAATAAACTTAATATCAACTAAAGCAGAAAAATTAGATATATTAAATAGGGATAATGCAAGAGTAATTTTAGAACAAGACACAGATATATCAGAAACAAAAGCTTTATCTAGTGCAATACTTCAAGTAGAAGATGGATGTTTTGGAGAAGTTATAATACCAGAAACACTTAATGAAAAGACAATACAATTTAAAGGGAATTTTGATAAAACAATAAAAGTAGAAGGACAAGCATATTTAAAGACGTACTCTAATGCTATTATTAAAAATGTTGAAATAAGATCAGATAAAAATAATGAAGTCGTATTATATGGAAGATTTAATGATGTAGATGTATATAGTAATGCAGATATAAAAACTAAGGAAGATACAAGTGCTATAATAAGGGCGAAAAATTCTGAAGCAAAATTAAATGCTAAAATATATGTACCTGAAGATACAGATATAAAAGTTAGAGAGTTTAAAGAAAAGAATATATCAGGATATGGGAGAAAGAAAGCATTATTTTAATTAAAAGATAGATAGTGAAATTATAACCATATATTGACAAAACACACGGGAAACGCTAAAATTAAATTGTATATTAAGAATAATCAGAAAAATATAAAAACGAAAGGAAGTGCTGTAATGTTTGATCAAAGAAGAGTTAATAAGATTATAACAACTATGGCCTTAACATTATCATTAATTTTATCATTATTTTCGCAGGTGTTTGCAGCTCCATATTTACCAAATGATTATAATAAGCAACCTGAAAATATAATTAAAAAACATTTTCCAAAACCAGCAGGACCTATATTAACTCCAGCTTTTAAAGAAGGTAAGAAAGACTTTACATCTCATGATGAAATGATGGAATTTATCTATGATCTTCAAAAAACTAGTAATCATATGAAGGTTTCAATTATTGGACAAACCCAAGAAGGCAAACCAATTCCCTTATTAATATTTAGTAATCCATCTTATTCTAATGCAGCAGATATATTAAAACTTGAAAGACCAGTTGTATGGCTTCAAGGGCAAATACATGGAAATGAACCTGCAGGAGGAGAGGGTGCCCTAGGAGTAGCTAAAAACCTTGCAGGTAAATTAGGAGATGAAGTATTAGGAAAGGTTTCAGTGGTAATACTTCCAAGATTTAATGGAGACGGTTCTTTTTATTTTCAAAGGCAAATGGCATCAAAACTAGATAGTAACAGAGACCATTTAAAATTTGATATACAAGAAACCATTTTAGTTCATGAAGCCTTTAATGAATTTAAACCAGAAGTTGTAATAGATGCTCATGAATATTCAGTTTTTGGTAAGTTTAAAAATGTAGGAAGTAAAGGTGGTTTAGTCTACCATGACATTTTAATATCTTCTGCTAAAAATTTAAATATACCAAAGGATGTAAGAAAGGTTTCTGATAATTTATTTGTAAATAATGTTCAAAAAGATTTAGTTTCTAGAAAGTTTTCAAGCTATGATTATTATACTTTTACTGAAAAAGGGGGCAAGCCAACTATATTTGAAGCGGGGACAGATCCTAAAATAGGAAGAAATGCTTATGGGCTTCAACCTTCATTTTCATTCTTAGTTGAGTCAAGAGGGATAGGTATTGGTAAAGAAAATTTTGAAAGAAGAGTACTAAGTCATATAGTGTCAGCACAAAACATAATAAGAACCACTGCTAATAATGCAGATTTAGTAAAGAAAACTATAGATAATGCACGAAAAGAAATAACTAAATTAGGTAAAACTGTAGATCCTAATGACAAATTAGTATTAAGAGATCTACATAAGAAAGTTGCCAATGATAAATTAGATATTATAGATATTGGTACAGGAGAAAAAGTAAAACTAGATGTAGAAGTTTTTAGCAGTAAAGAGGCAATACCAACTTTAGAAAGAGTAAGACCAACAGCCTATATACTTCCTCCAGCCTATCATGAAGTAGCTAAGAGGTTATCTTATTCAGGGGTGGTTGTAAGAAAGTTAAATAAAGATATGGAGCTTCCAGTAGAAGCATATAAGGTTAAAGATAAAAAGATTGACACAAATTATTACGAAGGACATTTAAGAAATGATGTTACTGTAGATGTAAGTAAAAAGAATGGAGCCTTTCCTAAAGGAAGCTATGTATTTACAATGGATCAACCAAATGCTAATTTAATAGCTATGTGTTTAGAACCAGATGCTGAAGATAGTTTTGTAAAGTTTAATATAATTCCAGCGGAGATAAATAATGAATTACCAACTTATAGATATGTAGAGAATAAAAATATAGATGCTAAGATAATTAAATAAAAATATATAAGTGTATTAAATAGCTTAAATTTTTATTCTAAGTAAAATATATTAAAAACATATAAACCTAAAAATCTTATAGATTTTGGGTTTATATGTTTTTATTTATATATGGAAACATCTTGTTACAATGTTAATTATAATGTTAATTATAATGTTAATTATATAGATGTATGTTAAGAATTAAGAAATTTTTACGATAACAATAGAAAAATGGAATATTGGTCTGGGGACACATCCAAATATCATAATTTGATTAATATTGTGTTCATGACCACTAATTATATTAAGAAGGAAGGATAGGTTTATGATTAAAAGTAAATGGGAAAAAAGAATTGCAAAGATTTTATGTGGTACTTTTTTAGTTACTACTATGATTTTACAACCTTTAACTGCTGTTAAGGCAGCTAAGAAAGATAGGGATAAGGAGAAAAAATATGTTAGAAAACCAGCTAAAGTAAGAATTTATGGTAAAGACAGATATGAAACGTCATCAAAGATATCAAAAGAAGGATGGAGTAGTTCCTATTATGCAATAATAGCATCTGGCGAAGATTTCCCAGATTCTCTAAGTGCAGTTACGTTATCTAAGAAACATGATGCTCCTATCTTATTAACTAATAGTAAAAATTTAAATAGGAATACAAGAGAAGAATTAACTAGAATGAAAGTAAAAAAGGTATTTATAATTGGGGGACAGGTCGCAATTTCTCCTAAAGTAGAACAGGATATAAAATCTATGGGAATTACTACAGAAAGGCTAGGGGGCAAGGATAGATACGAAACATCTATTAAAATTGCAGAAAGATTGGGCAACCCAGGAACATTATTTGTAGTTACATCTAATCATTTTGCAGATGCATTATCTGCAGGACCAATTGCTGCTAAAAAAGGAGCACCTATAATATTAACTTCTAAAGATCGTTTAGCTGATGTTACTAAGAAATATCTAAATAAAAAAGTGTTCAATAAAGTGTATATAGTAGGGGACAGGTCGCAAATAAGTGATAAAGTAACAGGTGAATTTGAAACACATGTACGAAATTTTAAAAGTGGTTTAGAGAGAATAGATTCTAAAGCTAGTGAGTATGTTAAAAATTCCACTGTATATGAAAGGAATATAAATATAATCAATAAGTTTCCCAATGAGTTAAATTCATACAAAGAAATATTTGTAGCTTCTGGTGTTGCTTTTGCAGATGCTCTTTCTGTAAATGCATTAGCTGCTAAAAGAGAAGCACCTATTGTAATAGGGAATACATCTGATGGAAACTTGTTAAAAAGTTTTATATCTGACAATTATTCAAAAATAGCTACAATAAATATTGTAGGTGGACAAGGTGTTATGTCTGAAAGTTATGTAAATAATATAGTAGATTATATAGAAGATGAGGAAATTAAATTTAAAGATGACAATATGGAAAGAGCTGTTAGAGAAAAACTAGGCATAACAAATGAAAATGAAAGAATTTATAAATCTAAAGTAAGGGATGTTAAAATATTAGATTTATCAGGATTCAACATATCAAAAATAGATGGAATTCAATTATTTGAAGGTCTTAAAGAGTTAAATTTAAGTAATAATAAAATAAAGAATCTAGAACCATTAGAAGATATGTTTTATTTAGAAAGTCTAAATCTATCAGAAAATAAAGTAGAAGATTTAGAACCTCTAGAAGAGCTTCGTAGTTTAAATTATTTGAATTTAAATAACAATAATGTAAGGTATGTAGATTCCCTTAAAAAATTAGAGTACCTAAAATATTTAAATTTAGGCAAGAATGATATAAGCTATATTGAAGATTTTAAAGATTTAACATATCTTTATTATTTGGATTTATCACATAATAACAACATAGGTGGGTTAAGTGATTTATCTGATTTAAAGAATTTAACTACATTAAAATTAAGCAATACAGGTATATCAAGTTTAGGCTTTTTAGAAGATTTAAAGAGATTAACAGAGTTAGATTTAGCTAAAAATAGCATAAGTAATTTAGATAGCTTAAAGAAGCTAGATAATTTAAAAACTTTATATTTAAATGATAATAACATATCTTATATAGAGGATTTAAAAGATTTAAAGGATTTAGAAGAATTAAATGTATGGGGAAATAATATAAAAGATGTTGAGAAATTTAAAAAGTTTAAGACACTTAGAAAGTTGATAATACAGAGATCGTTATTAGGGGATGATGATAGAAAACAACTAGATCTAATAGCAAATATTCCACATATTTTTGATAAGAAGAATACTTATGGAACATCTAAAAACGATATAGACAATAATTCTAAAGATATACCAAGAGAAAATTATAAGGACAAGGAATTAGATGATATTTCAAATGAATCTAAAGATCTTAAAGATACTTATAAACATGAATACAATCCTTATGAAGTGATATATAAATCCAACTCTGGATATAGCAGTGCGTTTACAGCTAGAGAACTTCTTAACCGTGAAAAAGATCTTAAATCTATGATAGAAAATTCTACCTACTCTATGGAAGTTAGAAAAATGATGCAAGAAGATTTAGAGAAAGTAATAAATCGATATGGAATGGTTAACAAAACCAATAGAATGAATGACAAAGTCATGGAATTAGAAGCTAAAATTAATATGTACTTTGAAGAAAAAGAAAGAAGAAAAGCAAGAAATAGAATAAACTATGTGTATTCAGATTATAAATATGACTTTTATAAAAATGCAGCTATGGAATGTGAAAGGGATATGTCACAATTAAAATCACAAATTGGACAACTAGAATATAGCAATAGCTATAGTGATAATGAGAAGGCTAGAATTTTAAAAGGTGAGTTAAGAAACAAGGAAATAGAATACTACATGATTAATAAAAATTTAAAGAAATATGATAAAGATAGAAGTTTCTTTGCAGCGATGGATTCTATATTAGATAAATAGTGCTTGTAGATTAATTATGATAAAGGAGGTATTTACATTAATGAAATATAAAAAAGATAAAATTAATACTTTTAAATTAGTTATACTATTACTTGTGATTTCAGCTATAAATATATTCCCAGGAAATAAAGTAGGAGCTGCAGAGATAACAACCAAAAGATTTAATGGAAGAAATAGATATGAAACAGCAACTAAAATATGTGAAGATGGTTGGAATGAAGAAAGTGACTGGGCAGTTGTAGTAAACGGGGATAATTTTGTAGATGCTTTAAGTGTTGCACCCCTTGCAAAGAAACATAATGCACCGATACTCTTAACAAATAGCAGAGTTTTGAATGTTTATACATCCATGCAGTTAAATAGACTTAAAGTTAAAAATGTATATGTAATTGGAGGAAAAGGGGTAATATCACAAAATGTAGAAGATGGCATAAAAGCTAAAGGTATTAAAGTTACAAGGCTTGGAGGGAAGGATAGATATGACACAGCTTTAGAAATTGCTAAAAAACTTGGAAGGCCAAAACAAATAGCTGTTATAAATAGCACAAGTTTTTATGACGGAGTTTCTATAGCTCCAATAGCTGCTTTAAAGCAAATGGCAGTAATTCCCGTAGCTAAAAATGATATGCCAAAGTCTATTGAGAAGTTTTTAAAGAGTAATAGAAGAGCTGAACAAATATATGTAATAGGTGGACAAGATCATATAAGTAACAAGATCTTTAATAAAATACCTAATGCAATAAGAGTAGGAAATGGAGATATATATAAAAGAAATATAGATATAATAAATGCATTCCAAAATGAATTGGATTTTGGTAATGTATACGTAGCCTCCTCAAGAGATTTTGCAGATGCTTTATCTGCATCAGCATTGGCTTGTCAATCATCGTCACCTATAGTACTTGCGGGAGGTAATTTAAGTAATAGTACCAAAAATTTTATGAAATCAAAGATAATAAATAATGTAAGTATTTTAGGTGGAAGTGCTTCTGTAAGTTATAATACAGAACAAATATTAAAATATTTACCTTTAAGAGTGGCAGATACAGAAAATATAAGAAAAGAAATATGGCAAAATGAAAGCTTTACACCACCGCCAACTATAGTAGTAACAGCAAACAATGGAAATATGGAAGAGGTTTCAGTAACTTGGAATTTAACAAGAGTCGATACTACTAAGCCAGGAATTTATAGCTTTGTGGGAGAAATAGACGGATACAACAGACAGGTTGATTTAATATTAATAGTAAGACCATTACCAGTTAAAATAGATGATATAAATAAGGAAGCTAAGAGTAGAGAGAGATTTGTATTACCTGAAAAGGTTGAAGTAGAAATGAGTGATGGCAGTAGAAGTGAACTTCCTGTTATTTGGGATTATGGAACAAAACAAAGCAATAAATCAGGAGTTTATGTTTTCTATGGTACTGTAGAAAAGTATGATAAAAAGGTTAAATTGACTTTAACAGTAACAGAATAGGGGACAGGTTGCAAAAAGTAATAAACAATTAAATTTAAAGTACCAAGAATAAATTTAACATTCTTGGTACTTTAAGTGTTAAATAAAGAGGAACAGGGGACAGGTCGCAAATCTAGATAAAATTATTTATAATAAATTAAATATCTCAGTCATTTAATTTGATGGCATAATCTGATAAAATTACAAAAAAATTATTACATATAAGTCTTTACTAATATAATGTAATAATGGTAACATTAAATTAATATTGGAACAAAATAAGGCTTTACTAAATCCTAGTGTATAAATTGTAAGGTTTTAATTGAATATGGAGAATATGGGTACAGAGAATTAAAAATTATTAGTAATATACTTAAGATAAAATTGGACAGATTATAATTGTAGAATAAAAAGGTGTTACTATAGTTATAATGTGTTTTTTATTAAAGGAGGAAGAATTTGATGTTAAGAAAGAGATATTTTAAGTTTTTAGGAGCAATGGTTTTATCTACGGTACTAGTGACAACTGTCAATACTGGAATAGTGAAGGCAGCAACATTAGATAGACTAGGAGGATTAGATAGATACAATACAGCTAGACAGGTAGCAGAAGGTGTTTTTAGTCAATGTGAAAATGTTATTTTAGTAAATGGACAAGGGTATGCAGATGCTGTTAGTGCTACACCTCTTGCAAAAAAGTTAAATGCACCTATACTATTGACTGAGGCGGATAAATTAACTAGTGGAGTTTTAGATACGATAAAAAAGATAGGAGCTAAAAATGTATACATAGTTGGAGGAGAAGGTGTTGTAAAACCATCTATAGAGTTAACTTTAAAATCCAGTGGATTAAAAGTAAATAGATATGCTAAAAGTGGAGGAAATAGATACGATACAAATGCTGTAGTTGCAAAGGAAGTTATAATGAAAACAGGAGCTAAGAAAGCTATATTAGTAAATGGACAAGATGGATACTCTGATGCATTAAGTGTTGCATCCATTGCTGCAAAATTAGAAATTCCTGTTTTAATTTCTAATTCTAAAAAAATGGACAAAGAGGTAAAAAAGGTTGTAGATGATTATAAGTTAGAAATTATGGCGGTAGGTGGAACAGCTGTATTACCCGATACCGTAGTAAAATCAGTTAATGGTAAGAGAGTTGCCCAAGGGCAAAATAGATATAAGACAAACATAAATGTCTTGAACTATTTTAAATCAAATCTTTCCTTTAATAAGATGTATGTAGCATCAGGAGGTAATGATAATATAAGAAACTTTGCAGATGCTTTAGTTGCATCAGCTGCAGCAGCAAAAGAAGGTTCACCATTAGTTTTAAGTGGGAATTCTGCTAGTAGTACCGATATAGCAGCTTCAGAAAGTTTTGTCAGAAATAATATAACTAAAGATAGTAAAATAACTTTAATAGGTAGTACAGGTGTACTATCTAAAGAAATTGAAAATAAAATGAGAAAAATTGCTGAATATGCTTCAGAAGGTGATTTGGAGATCATTGGTATAGAATAAAAATATAATAAATAGCATTGATTTATAGAATTGGAGGATATACATGAAAGACAGAGAAAGTAGGGACAGTTCACAAAAGTATATAGATGTAGAACTTTATTTAGATGAAGATTCCCAAAGAAAAATTTCCGACGTGCAAAAGGAGTATTTGGAGGAAGAACTAAGAGAAGTTATTCCAAATATAAAAGAAGGACAAATAAATATAGTAGGAATATACGCATTTGATCAAGGTGATAAAGTAGAAGTCAAAGCATATTTAGCAAATGGTTTAAGTAAAAAGATCAATTTTGAAGATGTTCCAATATACATCATAAATTCTAAAGAAGAAAAATTAGCATATCAAGTATTTGACCTTTCAGGAGAAGGCGATATACCATCAGGTAAGGCTATACCTGTAAAACTTAACTTTAACAAAGAAAATATGCTTGTGGATAAGATACCACAGGATGATTGGAAGGTAGTTTTTGGAGGTAATGATGTTAAAGGAGTTAGATATGTAAATATAGAATTAGAATCTATACCAGAAGGAATAGAAGAAAGTGAAGTAAAAGTATTTAAAGAGTTTTTGGAATCTTTACCTAAGCTTGAAAGAGGACAAGGGAGTATTTCAGTATTTACAATTACTCAATACGAAAATGGAGACTTACTTATGACTTTACTTGTGAGAAATGCTACAGATGAAGCAGTAACTATGACAAAAATGCCTATAACTCTAAAAACCGAAGAAGGAGAAACAATTTTATCAGGAGTATTTGATATAGAAAACTTTACAATAAATCCTTATAAAGCCAGAGTTTTAAGTCTAATTTTCAGAAAAGAAGTTGTTAATATAGAAGAAGACTTTGACTTAAGTACTTGTAAGATTATATTCGGAAGAGAATAAAATATTAAGGGACAGGTCACAAGAGAACTTCAAAAAATCATAAGAATTTAAGAAGTTCTCTTTATTTTTATGGGAATTTAAAGCAATAGAAATAATGAACATTAGTAGGCATAGTTATTATAGTAGGTGTTTTTATATAGGTTGTCCTAAGAATTCCAATTGGAAAAATAGATTAAATATATAAATTAAAAAAATACATAAAGAGCATGTTTAGTATTTTTTATATAAATGTATATTTATATAAATACATTTTAAGTTGGATTAGTATATTTAACCATAAACTTATAAAATATAGTTTCAAAATATTTGTTTTGGCTAATAAGCTCATAACCTCTGTTACATTGTTGAGATAAGGAAGAAGGGGTAAAGTTATTAAACAATGTTCCAACTTCTTTAATTTTAAAATTAGAGAAGGATCTAATAAGTAGTGTACAGAGGCATCGTAAGTTAGCGACACGTCTGTTATATTTTATGTTAAGATGAGTAGGATCAATATTTCCCATAGAGCATACAAAATTGATAATTTTATTAGGGCATATGTTTCGTGGTAAAAGATTTTCATCATTAATGAATTTATAAAAGTTTAGTAGATTTAAATTATTTTCATAACAAGGAAAATTTACATTTGTATTAATATAATTTTTAGTAATATAATATTTTTTGGAAATATTTATATTTTCATCAGTAAGATCAATGTCATTTCCAACAAAGTTAGCATATTGTTGCTTTGATAGTAATATATCAGAATTAAAATGACATAGAATATAAGAATAATCAATTAAATTAAAAGCATCTTTTAACTTACCAGTATATATACCAAAGCTAGAAAATCTATAGTTATCTAAAGAGTTTTTATATTTAGGTATATCTTTAGGATTATTATGTATATATGAAGATAAGAGAATTATATGAGATTCAGATTTTGCTAAATAACTTTTGAATCGATTTGCAAAAGCAGGTCCAATTCTGTCATATTTCAAATTATAATATTGAGCATAACTTTGATTTATTGACTTCATAAAATCGCTGATATCTGCATTATTTGAATGAATTAGTAGATGTATATGGGTGTCCATAAGACAATAAGAAAATACTCGAAAAAAGTATATGTTTTTATACTTTTGTAATATCTTTAAAAATTTAAGTTTATCATAATTATTTCTAAATAGTGGAGATTCTTTTGAGCCTCTCATTATTATATGGTAAACTCCATTACTTAATTTTATTCTAGTGTGTCTAGGCAATTTAATATACACTCCTTTATTAAATATTTATATTAAGCATTGACTAAATTTTTTATTTATAAACAGAAATTAATAAATTAATATTAAAAATTTCAATTTATCGTGACCTGGCCCCATTAATATCATTAATATTGTTGAATAGGAGAAGATTACTTATGGATTTTTATTCTTTGTTTTTAATAGCAATAGCTTTATCGTTAGATGCATTTGGAGTAGCACTTTGTATAGGACTAAATAATAATGTAGATTTAAAATATAAATCATCTTGTGCAATATATTTTGGTTTTTTTCAGTTTCTATTTGCTATAATAGGAGGATATGCAGGATTTTTATTTAATAAATATATTGTGATCATGCCTCAGGTTGTTGGAGGAGTTATTATATGTATTGTTGGTATTATAATGATAAAGGAAGGAATTGAAAATGAAGATGATTGTAAAATATTAAAACCAGGTATGAATATAATTTTAGGTATTTCTGTAAGCATAGATGCTATGGTTGTAGGATTTACAGCTTTAAATAAAATACAAAGTGGATTATTGATTCTTAGAGATACTTTATTTATAGGAGTTGTAACTTTATTTGTAAGTATATTAGCATTTATAACTTCAAAATATTTAAAGAAAATAGATGTTATAGGAAAATATGCGGATTATATTGGTGGAATAATTTTGATATTCTTTGGACTAAAAATGATATTTTTTTAAAGAAAAATAAAAACAATTTAAAATAGGGATGTAAATGATAAATAATCAATATAATATTTATTTATAAGGTGATATCATGAATATTGAAAAATTTTTAAAAGAAAATAAATTGAGAGTTACAAAAGGGAGAAGAAATATACTTTATATATTAAGTAGCAATAAAGATGCTGTTACAGCGGAGTATATACACCATAAGTTAATTGAAAAAAATATTAACATTGATTTATCAACAGTTTATAGAAATTTAGAGTTATTTAATAAAGAGGGTATAATAGATAAATTTGATGTAGGAGATGGTAAGTACAATTACTTGATAAATCCAGATAAACATAAGCATATTTTAGAATGCGCTATATGTCATAAAGAAATTGAAATAGATTGTCCTATTAAACAATTGGAACAAATTATAAAAAGCAGAACAGGATTTACAATAGAAGAAGAGTTAGATATAAAGATAAAAGGCTTGTGTGAGGAATGCAGTGAGAAATAAAGTTTTTGTATATAAAAATATAAGAGACAGCTTTTTTATAATTATAGATTTATAAAAAAGCTGTCTCTTATAATATTTTCAGGGGATAGATCATAAGAAATGAGAAGATATAATCTATTTTATTTTATATAAACGTTTTACTTTCCATGAATGATTTTTGTTTTTTTGTAAGAATATCTCGTAAGTAGTACTAGCATGGGGAGATCTTTTAGAAAGACCATTAATTTGCACAACAGAAGTTTGTCCATCAGAAAAAATTACATTAAAATTGTTTATTGAATATAACTTATGTTTTACATTAGTGAGCTTTTTAGTCATATGGTGATCTACAACAAATTCTATATCTTTATTTTTTTTAGAGAATAGGTATTGATTGAATAAAAATAATAATAGGATAAAAAAGAATAAAAAAATATTTTTTTTATTAAATAATATTTTTTTCATGTAAATAATATTCCTTTCTTAGAATATGTATAGTATATTTTATAATGGTAAATATTCTATAATGAAAATATAATATAATAGGAATAAATCGTTTTAAAAAAATGTATATATATTATAACATTGAAGTAAATAAATGTAAATAAGGAGTGGTATAAATGGAATTTAAATCATTAATTCTAATAGAAAAAGATATAGAAAGTAATGAATTTATAAGAGAAATGGATAGCTATGAATTAGGAGAAGGAGCCATGTATATAGAGAAGTTTTACTATGATGGAGGTTTTGTGAATATAGTTTTTAATATAGATGAAGATATGGAAGATTGGAAATATAACTCTATATTAGATTATTTTAATACAGAGATATTTGAAAAATACATATGCTCTATAGAAGAAGTAGAAGGAGAATATAATCCAACTTGGATAATAAAGTTTAAATATACAGATAATTTTGATTTAATGAGTGAAAAGTTGGAAGATATATGTGAAGAAATCTATAATCAAATAAAAATAGTAATGGAATTTGTAGAAAAAAATAGAGACCAACTTATTTAACTAATATGGAAATATTTATAACCTAAATTATTAGAAAGAATGTAGAAATATTTAAATCTCGTGACTATTAAGATAAATAAATTATATGAAAGTTTAATTAAATATTAACTATAATAAAAAGAAAATTGAAATATGTATGTTCTATTTTAAATTATAGAAAAATGTGGTACTATATTGTTAATATTTATCTATAAAGAGAGAAATTATATTTTAATGTATCTAAATAGTATTTAATGAGGAGAAATATTATGAGGTTAGAGTTCATTGACAAAGTCAAAGACAACGAAGTATTGGGTAAAAGCATATTGAGTTCAGATGGTCAAATGCTGCTTAGAACAGGTATTAAATTAACTAATAATTATTTATCAAAACTAAAAGATATGGGTGTCTTATATATATATATAGAAGATGAAAGATTAGAGGATATAAATGTAGAAGATGAAAGATTTATAGAATTAAAGCAAAGGACGATTAAAAGTGTAGCAGATATTAGTAAAAACATTCATGGATACTCTGGGAAAAAGTTTAAAAAAGCTATATCATCAATAGAAAATCTTGTGGATTATATAATAGATATTGGTGATGTTAATAAAAGTCTATATGATATAAAAACTCATGATAATTATACATACCTTCACTCTCTGGATACATGTGTAATGACTTCTTTTTTAGGAATTTCATTGGGTTTTAAAGAGGACGAGTTAAAAGATCTTGGTATAGGGGCTTCACTGCATGATATAGGAAAAACACAAATACCTTTAAAGATATTAAATAAAAAAGGAAAATTAAATGATGAAGAATTTGCCGAAATAAAAAATCATACATTATATGGTGGCAAATTATTAAGGAATAATAAACGAATCTCCGAAAATGTAATAGATATTGTAGAACAACATCATGAAAGAATCGATGGTAAAGGATATCCTTATAAATTACATGGAGATGAAATATCAAAATATGCTAAAGTAGTTAGTTTATGCGATGTATATGATGCCGTTAGCAGTGATAGATGTTATAGAAGGAAGTTCTCTCCTAATGATGCATATGAGCTAATACTTGGAAATTCAGAAACAATGTTTGATATTGAGGTAGTTGAAAAATTTAAGGAAACTTTCTCAATATATCCTTTGGGTGCTTGTGTTAAACTATCTAATGGAGTTGAAGGGTATGTTATACATCAAAATAGAGGTTTTCCAGATAGGCCTTTGATACGGGTTTTATATGACAGTGGGACAAGGGAGCCAGTTCAATTTTATGAAATAGATTTATTAAAACACAAAAATCTAGTAATCAAAACTATAGTTTAATTACTATAGATTAAAGTGAATATATTGAAATTTAAGACAGCTATAATTTATTAATTAGTAGCTGTCTTTACATTAATAAATTATTATATACTTATAATAAATTCAAATATAAATGTTATAATAGGTATATAAAAATATTCATATAAGGAGGTATTTAATGCAAATAAATAATAGAAATAACAGATATGCTTTTGATGAAGCAATAAATTTTATTATTGAAAGCTCTGTAAAGGCGTTAAGATACAGTTTATTTGAATTAAATAATATAGATAATGAAACCATACTAAGTCCATGGATGTTAGTAAGATTTCAAGAAGATATAAATGAAGTTATTATATTTTGTAGTGAAAAGTATAATAGTTCATATGACTACGACACTAAATTAAGTGTAGTTAAGAGTCTACAGAATAAATTTCCTAATTTATCAATATATAATATAACCCTTATAAAAATTAAATTCGTGGGACAGGTCTCAAGTAATGGTAATTATTTTGAGGAAAATTGTGTCTTAGTAAATTTAAATGAAAAGAAAATAATTCAGTATAGTAACGGTTTAGAAGATTTAATTGAAATAATAAGATTTTATATGAATAATACTTATTCTAGGGAAAATGGAAATAAGAAAATAAAGAGATTTATTAAGGAAAATACTATAACATTTATATTAATAAGTATGAATATAATTATGTATCTTATAATAGCGTTACTTTCTGGAAACATAATCGATAGTAATATAGATGTTCTTATATTTTTAGGTGCCAAGGTAAATCCTCTAATTGATATAGGGCAATACTATAGGTTATTAACTTGTATTTTTTTACATGGAGGATTAATTCATTTAGCTCTTAATATGTATGCTTTATCTGCTCTAGGACCCTTAGTAGAAAAAATATATGGAAAGTTTAAATATTTAGCTATATATTTTTTATCAGGAATATGTTCATCTCTATTAAGTTATTTTATGTCATCAAGTATTTCCATCGGAGCTTCTGGAGCAATATTTGGTTTGCTAGGGGCATGTCTTGTAATTTCTTTAAAATATAAAGACAGAGTGGGAAAAGTCTTCGTAAATAACATAATATCAGTAATTTTTGTAAATCTAATTATAGGGTTTTCGGTTTCCAATGTAGATAACTTTGGTCATATTGGAGGATTAATTGGAGGAGTATTAATATCAACATTAATTTGTAAATAA

Protein sequences of DBSCAN-SWA_1

>NC_022777|459142:532262|497705_498143_+|WP_023437341.1|DBSCAN-SWA
MENKIKGFNKKIVALIMIASISVAGIGCSSKKGEASSNKDNKTKKEESVKKDVEVKEKEDPKNKIEKDEKLTNKIKKEKIVSNGDVYEQGEYVYATLIIKEDAKKEEIDKVANEYAKKLKSEHKDKKVSVQAVQGGKNVADITLK
>NC_022777|459142:532262|507027_508962_+|WP_039260614.1|DBSCAN-SWA
METIKMTTAQALIKFLNQQYVELDGQECRFVRGIFTIFGHGNVLGLGQALEEDPGHLEVYQGHNEQGMAQSAIAFAKQSYRKQIYACTSSIGPGAANMVTAAATATANNIPVLLLPGDTFSTRQPDPVLQQVEQTYNLSITTNDAFKAVSKYWDRVNRPEQLMTAMINAMRVLTDPANTGAVTIALPQDVQGEVYDFPEYFFKKRVHRIERTPPSKQAIEDAVELIKRKKKPLIICGGGVRYSEAAESLKRFSEEFNIPFGETQAGKSAIEWSYELNLGGIGVTGNSAANSIAKDADLIIGVGTRFTDFTTCSKFLFQNEDVEFLTINISNFHANKLDAVKVISDAKVGLDTIANELEKQGYTSAYKDEIKKAKNEWKKELNRLFNIEYTKREFVPEIAGHCDEVVEEFYKEFDSCLTQTKVLGELNELLDDDAIVIGASGSLPGDLHKVWCPKKSNTYHVEYGYSCMGYEVSAALGVKLAEEDKEVYSLVGDGAYLMLHSELITSIKEGKKINILLFDNAGFGCINNLQMSNGMGSFATEFRHRNNETGKLDGKLLKIDFAKSAEGYGVKTYKVNTIDKLKYAIADSKKQKISTLIDIKILPKTMTGGYESWWHVGVSEKSKSPKINKACESKINHLAKARKY
>NC_022777|459142:532262|478475_479789_+|WP_023437327.1|DBSCAN-SWA
MKKRFKLNKKYLIFGVIAVVIILVAFSTIKGKKDNFTQVSTNTVSKKNLNKVATATGNVEANHRNDIALNPSLKVIKVNVKEGQMIKKDDVLVELDSKDLKTQLEKAELNLKNANDTLAQFQGAEVENQKKTASGSLVQARLALENAKSTHEDLSKKLSQNKKLFEGGYVSQNEYDASVKAAKEAENGVKNAEAALKNAENNLSGIDISTNNKIISQRNQIAMIQSDIKSIKDKIEDCYIKANVSGKIVRMDAKENQYPNAGEMIVIDDVSKYRVNADINQYDAVNIKKGQKVNIKIKGIDKEYKGKIEEVGEIAEKKIAKSGAGADAEHKLNIKVALDKSDSKVKPGYEADLEIILQERKSSLAIGFDAIRQDKKGGKKYTYVLDQDNVVKKREINTGLETEYDVEILGGLKEGEKYIINPPENLKDGERVNPAGE
>NC_022777|459142:532262|463053_463368_+|WP_023437313.1|DBSCAN-SWA
MDQTKSYVFRIVRDSSESADSGEHKIESTKIGILEGTTLKDIPTGTTIEQLKKALTVSKGANIHFVKKNEQNTPEIKDLTELVTDEMEIVVESGTQTVYTIEII
>NC_022777|459142:532262|504330_505176_+|WP_023437347.1|DBSCAN-SWA
MSIVKMKQLLKNAKKGQYGIGAFSISNMETIIGAVRAAEELKSPIILQIAESRLKHSPLYLIGPVMIEAAKKSSVPIAVHLDHGESIDTIKEALDLGFTSVMYDGSHFNLSKNIESTKEVVSLAKEYGASVEGEVGKVGKKEDGLGDDTISITTVEEAEKFYKETNVDALAIAIGNVHGMYVGKPNLNIKRLIEVNSNVEVPLVLHGGSGITKEEFKNCIKNGITKINVATATFNSVVDKVNELFKTSSSVDYFTYHDIVIDAAYDNVKKHIEIFGSSNKA
>NC_022777|459142:532262|475519_476329_+|WP_023437324.1|DBSCAN-SWA
MDFDYFNQIIVLYGSKIILAVATLVIGLYAIKKIVGLLFRRFSKIGLEKSLQSFSISFTSIGLKILLAVTIASMLGAEMTSFVAILGSAGLAVGLALQGSLSNFAGGVLILILKPFKVGDYIEAAGHSGTVSEIQVFYTILNTPDNKKVIIPNSNISNGSVTNYSANTTRRVDLVFSIDYDEDIERVKKVLTNIIESNSLILKEPIPQILVGEHGDSSVNLYVRVWCENKDYWNIYFGLMEKVKVEFDRESINIPYPQVEIQYKGEKAQ
>NC_022777|459142:532262|467028_467454_-|WP_023437317.1|DBSCAN-SWA
MYCYTLATNLTCVFNELLLWTDISSEHPIFIETVAKLTNKKLPKKLLDELKKVNSDFSKLNKKVENLKKRCFSHGPANPYVIMEIKKIIHEFFQYDMYFINLLCNIMEYGKEDKVWQTLLHHIHHEQKFMYELFTQLYKQL
>NC_022777|459142:532262|528348_528762_+|WP_023437364.1|DBSCAN-SWA
MNIEKFLKENKLRVTKGRRNILYILSSNKDAVTAEYIHHKLIEKNINIDLSTVYRNLELFNKEGIIDKFDVGDGKYNYLINPDKHKHILECAICHKEIEIDCPIKQLEQIIKSRTGFTIEEELDIKIKGLCEECSEK
>NC_022777|459142:532262|478023_478479_+|WP_023437326.1|DBSCAN-SWA
MEDKKIFELLKDITNLSKLMNRKLNAKMDGKKISPYPIIILNQLDRKKPTTLTDIREKLGIPNSTISTVLDKLLEKGLIKKEKDETDKRRTFLYLTEKAYEEEKKIIKQHVEVFKEVLSKATDEDLNTLINSTKLFIKLIEEDNKEDEYKL
>NC_022777|459142:532262|510979_512005_+|WP_023437353.1|DBSCAN-SWA
MNKIKVGIVGLGRLGRKHAENIALRISNAELTAVCSVIKDEVDEAYKKLNVKYGYTDFDEMIKNKELDAIFISSPSGFHCSQIEKALKAGFHVFSEKPLGLYLEETKKLAKVVNEYRDKQIFMLGFMRRYDKSYLYAKEKIEDGEIGKPMLIRCYGLDPSCSIESFLSFAKNNYSGGLFLDMAIHDLDLARWYLNSEAEKVWAIGDAYEYEDFKKINDAETGAALVKFKNGTIGIFVAGRNCAHGYHIETEIIGTKGSLRIGTIPEKNMVTVFNDKGAIRECYQGFLERFEQAYLSETEDFINCIMEKRQPKITVEDGVNSTALAYACKESFETGKLIELK
>NC_022777|459142:532262|472092_473640_-|WP_023437321.1|DBSCAN-SWA
MGVKFLKAHEAANLVKDGDLIVTGGFVGSCCPEALTKALENRFLETSSPKDLTLMYAAAQGDGNGKGADRFAHIGMTKRVLGGHWNLSPSLGKMAINNEIEAYNLPQGTLSQLFRDIAGKRIGTITHVGLNTFVDPRLEGGKLNEITKKDIVEVINIKGEERLLYKSFPIDICFLRGSFADEKGNVTLENEVASLEVTSIAQATKNTGGIVIVQVEKVVECGTLDPRLVKIPGIYIDGVVIAEPEDHEQCFGCEFESARTGKVRIPVSSVEKAPLNQRKVIARRAALELEPDTTVNLGIGIPEVISSVANEEGIGEYMTLTVEAGAIGGVPEGGTAFGACINPESILDQAYQFDFYDGGGLDLAFLGLAQTDKNGNINVSKFGPRIAGCGGFINITQNSKKVFFCGTFTAGGLKIEIKDGKLNILQEGRSKKFINQVEQITFSGEYAKKIKQPVMYITERAVFELKDDGVYLTEIAPGINLQKDVLDLMDFKPKMDGEPKLMDSRIFFDKPMGLK
>NC_022777|459142:532262|496534_497476_-|WP_080751363.1|DBSCAN-SWA
MNIVDNFKYIYGPIPSRRLGLSLGVSPIPKKFCNYSCIYCQIGLTHNLTNTRREFFPLEDIINEFKKYISYDKDFDVISIVGEGEPTLYSKLGKLISSLKKLTDKPIAVITNTGLLYDKNVQEELLNADIVLPSMDFFSEESFRSLHRPYGKLDFQQSYDGLVEFSKKFKGELWLEVMLIENINSSKKDLIKLKELIKNINYSKIYINTAVRPPAESWVKPASKETIDFAVDLLDGISIDMLSNGNFISETKDNYQAILSIIKRHPMNQHELKGFLSIRGVNEEDIQNLFLRLKEDNNIEILNYKGFHTYRLK
>NC_022777|459142:532262|490058_492152_+|WP_039260613.1|DBSCAN-SWA
MGKKKITIILLTAFLTTIVVPAFGVTMQGNNFINSKVHAYENKDTEDYDLEEGIKFPDKELEKVIREQINKPVGAIEKSDLSNISELDIRNKAIKSIEGVQYLTGLQTIDAANNKICDLSPISDCTSLSKINFSYNKIEDISPLKNLTILEKVYLKDNEIKKVDALEDLREMKELDLSSNEIKNLKPLTYLSNLKTLTMADNGLKDIDDLGSLEKLESLTLSKNNISDISAIKVIRNLTKLYIDDNQVEDVYPLVGMDYLERINLDKNKIKNIGELEANKDNLKWVKYRGKEITDIGTLKYIVEQANVVVNFKDRNLEREVRKKIEKPLGELRLADVEYIKDLNLFAKNIKDISGMEYLRGLRWVNLGKNNISDISPLKDLEDLEGLYLYKTKVSDITPLQGLENLKKLQITSTNLSELHPLKNLTNLERLELGENKIFEVDDLQGLIKLEVLDLSDNYIKDISSLKNLTDIKELKLNKNKVSDISIVANMKDLQRLYINDNNLTTLKHLKDAKDLVWLTANNNKITSLEGLEDLIDIKEIHVDNNKIAKLDPLKNLKELETLSARTNVISDLKPIENLDYIKNLYLYENKISDISPLKNMTGMLRLYLDKNNIKDISVVANMKDVTTLSLGDNNIINLAPVAGLEDLGTLDIGDNDIKDITVLYNLPSLEKLVVTNNDNLPKHQINALSKDVKVVY
>NC_022777|459142:532262|498342_498792_+|WP_023437342.1|DBSCAN-SWA
MNISKKYKKIFKYILVIIWMVIIFKFSSDPGEISDGKSGLIVEVINNLGINVSSTLGECANFIIRKTAHMGEYFILTLLLISALKEDFNWKKTCWLGILITFLYACSDEIHQRFVPGRCGQFSDVLIDLFGGILAIFIVKVFNNFKKQK
>NC_022777|459142:532262|479806_480520_+|WP_172645118.1|DBSCAN-SWA
MIKLEDIEKIYDTGAIKLKALNKINLSIDEKEFVAIMGASGSGKSTMMNILGCLDNISFGKYYLDGVDISSLDSNELAAIRNKKIGFVFQAFNLLPKLTSIANVELPMMYAGVPKEERKIKAQKALERVGLGDRIYHKPTELSGGQKQRVAIARALVNDPSILLADEPTGNLDSKSTVEIMGIFQELNNEGVTIVMVTHEDDVAMHTKRAVVFKDGNIISDKLINESERIIVGGQQS
>NC_022777|459142:532262|484327_485152_+|WP_023437332.1|DBSCAN-SWA
MKKKISIILAIIFILVTFSSAFVMFKGNRKDSKVNSRESKQSNVDFYVKYAYADIDMDQIIQDVDKKDDDTSADYIFIRFSAEVIQNNDETSIGNPNNYKLNGQPLPKGSESFIRKEMPQLLIFKIPQGTLKNKNSGHTIEISKNVLNGKNKIIGETKLLLPYSEPIKDEGQNKKDDNKEKNNKGQDVKNGQNKNVSNVPKYKVEVGKGIPYNTLVLVKIQEGKAEDYKVSIDNVGLEIKETNEKQKVHVGYVKKDYSYSEVLQKVKVEKIIKK
>NC_022777|459142:532262|460849_462832_+|WP_023437312.1|protease|DBSCAN-SWA
MDQAKSYVFRIVRDSKETEEKEKQEQAEKERQKKLADAQSVQKAKDNLNLTNLNNVSSNINLPKDIDGVSITWKSNNTSVLDEKGNVTRPSATKGDTLVTLTATLTKDEAKDTKDFIVTVKAKDFTDEELVDMALGNLQPEGKLDSVVDNLKLPTKDDKNAVDITWNSSNESVVSNAGVVTRTDKDENITLIATLKKGSITKTKEFNIVVKAKEKDTQEALKLIANSLEISNKGSIEKDINLPTSLDGATVIWKSNNEAVISNTGKVTRPKIGKSDEKVTLTATITKDGKNETKDFTVTVKAEKQLVANNKQEFNEILKQAIIDCEPTVDISLPNFDTNNNVYKFDDYQNLLIEIGEMDFGKPGVEGNYKNDGKGWIMTVEFKYRKDAAEIKRQKEATIKKAKEVVKDVIKPGMKHYEKELALHDYIVKTADYNVENYNKGKTTLEDHTAYGVLVDRIGVCESYAKAMNLLLKEVGIDCKYVTGFSKHNGVKGGGHAWNMVQLDGEWYNLDATWNDPVSDRNGAESVNKDNTSPATVNHTYFNLPDDIFNNDHIRGDFEEKNYPKCTATKYSYHNMDVDEYTADGKLIEKVTTKDELDAKILEAIKNKEKTLSLRIKGFKMTQKELSDEFKAVAEKNRVGGCSWSTSAPDDYHVNYTIKW
>NC_022777|459142:532262|531224_532262_+|WP_023437368.1|protease|DBSCAN-SWA
MQINNRNNRYAFDEAINFIIESSVKALRYSLFELNNIDNETILSPWMLVRFQEDINEVIIFCSEKYNSSYDYDTKLSVVKSLQNKFPNLSIYNITLIKIKFVGQVSSNGNYFEENCVLVNLNEKKIIQYSNGLEDLIEIIRFYMNNTYSRENGNKKIKRFIKENTITFILISMNIIMYLIIALLSGNIIDSNIDVLIFLGAKVNPLIDIGQYYRLLTCIFLHGGLIHLALNMYALSALGPLVEKIYGKFKYLAIYFLSGICSSLLSYFMSSSISIGASGAIFGLLGACLVISLKYKDRVGKVFVNNIISVIFVNLIIGFSVSNVDNFGHIGGLIGGVLISTLICK
>NC_022777|459142:532262|528876_529206_-|WP_023437365.1|DBSCAN-SWA
MKKILFNKKNIFLFFFILLLFLFNQYLFSKKNKDIEFVVDHHMTKKLTNVKHKLYSINNFNVIFSDGQTSVVQINGLSKRSPHASTTYEIFLQKNKNHSWKVKRLYKIK
>NC_022777|459142:532262|516040_517753_+|WP_023437356.1|DBSCAN-SWA
MLSLATAITTTKTSAAELAKITRICGVDRYQTAVKISQNGWKSGSDYAILASGEDYADALCATSLAKAKDAPIFLTKKNSLNEETLKELKRLGAKKVYIIGGDGSISEEMENEVKSVVKNTERLQGKDRYETSVKIAEKLGESNKVILTSGEGYADALSIAPVAAIKGIPVVLTKVRELPTSTKEYIKSIGATTTYVIGGTAAISDTVKNLVPSPERIYGQDRFETNSEIIKAFAIEFDFENAYVALGLGSTGKEFADGLSASALSAKNRAPVILTGQTLNSVTRDLAREKLYPTTNLTVLGGVKNISDTAVGEMKVTGEIIKTEKELEDKNIDGNLAITVKNAELRDSKIKGNLYIENDNILLSNVKVDGTIYINPRSENTCKLENVMANKIIVLSGREEGINLISTKAEKLDILNRDNARVILEQDTDISETKALSSAILQVEDGCFGEVIIPETLNEKTIQFKGNFDKTIKVEGQAYLKTYSNAIIKNVEIRSDKNNEVVLYGRFNDVDVYSNADIKTKEDTSAIIRAKNSEAKLNAKIYVPEDTDIKVREFKEKNISGYGRKKALF
>NC_022777|459142:532262|499005_500169_+|WP_023437343.1|DBSCAN-SWA
MKYGIRADNLYLENVILQDGLVIIDDDRIEKVVCYNEIEILDSKLEKVYNLSNKKILPGIIDTHIHGGDGYDTMNGNFEALNGISKYLVSRGITAFLPTVVTDHMEKIKIALKNVKDSMGKVQGAEIIGSYLEGPFISKEFKGSHAENLIRKISIEDFKELIYMSENTIKIVVLSPEKKGAEEFIKFCKEKGIIVALGHSNATYEETIKAIENGAKVGVHTFNGMRSIHHREPGIVGAILTCDKVYSEIICDFIHQHPTTIDISLRCKPKDKIVLISDSIEAAGLKDGEYKLGASKVNVKDSIARIDNGALAGSTIDILKSIKIMIEKLNVDCLDAVNMASINPSRELGIDKWVGSIEQGKKANLTIVDMEYNPYMTIVNGKVVWKR
>NC_022777|459142:532262|467716_469423_+|WP_023437318.1|DBSCAN-SWA
MKNLNLSKRLILSFTLLIIVIITNGIVGIRSVNKMDFNANEIAGSMDAINRIRHIETHLIESKASTIILLNEKDVNKINRLKEELNSLSEETNEIIRECINSQDSWFKGEAEVFKEFQNKLKVYRSTRDDICNLVLQNNYNKVLTLKEVHKNQWMELNELINKIIDINIKGGDKKKIDNHIIHKDSVYIVSFTMVLGVVFSVFFVINLYKYIMKNLRKVIKFSHRIAKYDFSEDIVTERKDEFKDIGDALNIAQDNVKKLISTIVLKSKELSKFSEELFATIEEMNAKFSEIDKDTNKIAREMQESSSATEEISASVQEVDSSINILTQKAVDGSNVSIKSKERADKVYKNGELAVKETEELFNKNKEKILKAIEEGKVVEDIKVMADTIASIAEQTNLLALNAAIEAARAGENGKGFAVVADKVRELAEQSSESVLNVKLTIEKVNKAFNELSENSILTLKFIDSKVRSQFDDFSHMGYHYYKDAEFTSKMSEDIASMVEEINAITKEVNISVQGMADMVQESFKSSYSIEESIKESSDAMEQIAITAQTQSELAQNLNEIAERFIL
>NC_022777|459142:532262|505195_506215_+|WP_023437348.1|DBSCAN-SWA
MNYIKFDEKKPLDVIPIGRVTIDFNPNEVNRPLEESRTFTKYLGGSPGNIAVGLARLGKRIGFLSTVSDDQFGNFVISYLKNEGIDISQINRAKNGEKLGLTFTEILSPKESSILMYRKGVADLQLSPKEVSEDYIKSAKAIVISGTALSKSPSREAAFVALEYAKKHNTRIIFDLDYRKYTWNCKEEIAIYYSLAARMSDIIMGSREEFNLMEGLISPEGSNDKETAERWIGYGNKIVVIKHGKDGSTAYLHDGTSYKIKPFPVKLLKSFGGGDAYASAFIYGIMEGWNVIDALEFGSASAAMLVASHSCSEAMPKVEEIKQFIKEKKEEHGEMVVRG
>NC_022777|459142:532262|502101_502869_-|WP_023437345.1|DBSCAN-SWA
MLKEDRIKGIENYVIKHENVSINTLCSLFDVSKNTIRRDISELERKGVIKKIYGGITLKNKTSTVPFQQREIKYKETKKIIAKAASNLVENGDIIYIDSGTTTMHMIPFLSDKKNVNIITNNVNVIVNSFPYKNLNILSTGGSLSRNTNSLIGVESINFLKNYNISKCFMASTGVSIKKGVTNSSSFEYEIKRTVVKQSSKIILLADSSKLGMASLMTYCNLEDIDTFITNEPLSNDYLDFFNKNNIELIISDNL
>NC_022777|459142:532262|469504_470809_-|WP_023437319.1|DBSCAN-SWA
MDIWIIIIALVLFTILAFKRVSALILGPLVSLFVIVCSRLPMFNTMLGPYMNAAANYVEKFFLVFFVGAVFGSIMQETGAAESIAHSLIKITNGKFVAPLIMIITGLLTYGGISGFVVFFAMYPIAVELFKSANLSRRLIPAAISAGAWTWSMTGPGSPSIQNIIAMRYLETSSTAALLPAIASALAQLILICVWFEYRSSKLTKKGYTFYEDPTIIPYIDDKNISKNNKDLPNPIMSAIPAILILICFNIIELPVEGAVTIGIISAIVLLWKRIDSPSEWINTLNKGAINSATAILNTAIVVGFAGVVKETPGFEKIINKLKTMKMSPMLFVAITVAIASGAAGSASGGLGIAFESLKDTYINMGVNLEYVHRISVIASGTFDTLPHQGAQITLLAICGLTHKEGYFDIAMTQIIFPILVLLLVTIPMCSIGL
>NC_022777|459142:532262|525481_526321_+|WP_023437361.1|DBSCAN-SWA
MKDRESRDSSQKYIDVELYLDEDSQRKISDVQKEYLEEELREVIPNIKEGQINIVGIYAFDQGDKVEVKAYLANGLSKKINFEDVPIYIINSKEEKLAYQVFDLSGEGDIPSGKAIPVKLNFNKENMLVDKIPQDDWKVVFGGNDVKGVRYVNIELESIPEGIEESEVKVFKEFLESLPKLERGQGSISVFTITQYENGDLLMTLLVRNATDEAVTMTKMPITLKTEEGETILSGVFDIENFTINPYKARVLSLIFRKEVVNIEEDFDLSTCKIIFGRE
>NC_022777|459142:532262|494621_495581_-|WP_023437338.1|transposase|DBSCAN-SWA
MVIILENNISKDVFLLPRSARVKTDNSIFHIMVRSISEVNLFQTDFDKIQYLNFVKLYKEIFNFKVYAYCLMSNHGHFIIDANGADISKIMHGLNLKYSLNFNKRYKRRGHLFQDRFKSKIIDSQKYLITASAYIHNNPVDIQKYSKHPEKYRFSSLAVYLGLKKDPFKILDENYIMQFLGNNLEAARKNYIRLICMSNDEESIKSFKFQNEKTIYTSERKSIIRDCTPEDVIDFISKQTKTDKVKLYIKNNRSILKSRALAVLLMRGFCDFTCADICKSIGNITQSTVSNMCKLAINAIDEDKNFRRIINNFVEIYST
>NC_022777|459142:532262|530008_531067_+|WP_023437367.1|DBSCAN-SWA
MRLEFIDKVKDNEVLGKSILSSDGQMLLRTGIKLTNNYLSKLKDMGVLYIYIEDERLEDINVEDERFIELKQRTIKSVADISKNIHGYSGKKFKKAISSIENLVDYIIDIGDVNKSLYDIKTHDNYTYLHSLDTCVMTSFLGISLGFKEDELKDLGIGASLHDIGKTQIPLKILNKKGKLNDEEFAEIKNHTLYGGKLLRNNKRISENVIDIVEQHHERIDGKGYPYKLHGDEISKYAKVVSLCDVYDAVSSDRCYRRKFSPNDAYELILGNSETMFDIEVVEKFKETFSIYPLGACVKLSNGVEGYVIHQNRGFPDRPLIRVLYDSGTREPVQFYEIDLLKHKNLVIKTIV
>NC_022777|459142:532262|519839_522455_+|WP_023437358.1|DBSCAN-SWA
MIKSKWEKRIAKILCGTFLVTTMILQPLTAVKAAKKDRDKEKKYVRKPAKVRIYGKDRYETSSKISKEGWSSSYYAIIASGEDFPDSLSAVTLSKKHDAPILLTNSKNLNRNTREELTRMKVKKVFIIGGQVAISPKVEQDIKSMGITTERLGGKDRYETSIKIAERLGNPGTLFVVTSNHFADALSAGPIAAKKGAPIILTSKDRLADVTKKYLNKKVFNKVYIVGDRSQISDKVTGEFETHVRNFKSGLERIDSKASEYVKNSTVYERNINIINKFPNELNSYKEIFVASGVAFADALSVNALAAKREAPIVIGNTSDGNLLKSFISDNYSKIATINIVGGQGVMSESYVNNIVDYIEDEEIKFKDDNMERAVREKLGITNENERIYKSKVRDVKILDLSGFNISKIDGIQLFEGLKELNLSNNKIKNLEPLEDMFYLESLNLSENKVEDLEPLEELRSLNYLNLNNNNVRYVDSLKKLEYLKYLNLGKNDISYIEDFKDLTYLYYLDLSHNNNIGGLSDLSDLKNLTTLKLSNTGISSLGFLEDLKRLTELDLAKNSISNLDSLKKLDNLKTLYLNDNNISYIEDLKDLKDLEELNVWGNNIKDVEKFKKFKTLRKLIIQRSLLGDDDRKQLDLIANIPHIFDKKNTYGTSKNDIDNNSKDIPRENYKDKELDDISNESKDLKDTYKHEYNPYEVIYKSNSGYSSAFTARELLNREKDLKSMIENSTYSMEVRKMMQEDLEKVINRYGMVNKTNRMNDKVMELEAKINMYFEEKERRKARNRINYVYSDYKYDFYKNAAMECERDMSQLKSQIGQLEYSNSYSDNEKARILKGELRNKEIEYYMINKNLKKYDKDRSFFAAMDSILDK
>NC_022777|459142:532262|517870_519532_+|WP_023437357.1|DBSCAN-SWA
MFDQRRVNKIITTMALTLSLILSLFSQVFAAPYLPNDYNKQPENIIKKHFPKPAGPILTPAFKEGKKDFTSHDEMMEFIYDLQKTSNHMKVSIIGQTQEGKPIPLLIFSNPSYSNAADILKLERPVVWLQGQIHGNEPAGGEGALGVAKNLAGKLGDEVLGKVSVVILPRFNGDGSFYFQRQMASKLDSNRDHLKFDIQETILVHEAFNEFKPEVVIDAHEYSVFGKFKNVGSKGGLVYHDILISSAKNLNIPKDVRKVSDNLFVNNVQKDLVSRKFSSYDYYTFTEKGGKPTIFEAGTDPKIGRNAYGLQPSFSFLVESRGIGIGKENFERRVLSHIVSAQNIIRTTANNADLVKKTIDNARKEITKLGKTVDPNDKLVLRDLHKKVANDKLDIIDIGTGEKVKLDVEVFSSKEAIPTLERVRPTAYILPPAYHEVAKRLSYSGVVVRKLNKDMELPVEAYKVKDKKIDTNYYEGHLRNDVTVDVSKKNGAFPKGSYVFTMDQPNANLIAMCLEPDAEDSFVKFNIIPAEINNELPTYRYVENKNIDAKIIK
>NC_022777|459142:532262|470919_472059_-|WP_023437320.1|DBSCAN-SWA
MNFNLTPEQELLVKRVREFAEKELKPIAIENDENKEFPMEAYKKLGEMGILGLPYPVEYGGTGGGYLAYVLAVEEISKVHASLGISYSVNASLCSGAIYNNASEELKKKYLPDLSTGRKIGAFNLTEPEAGSDASNGSVTAIKEGNHYIINGLKCFSTNAPVADTFVVFAITDKSKGAKGISAFIVEKDFPGISIGKVENKCGINAAQVSDVIYDNCKVPSENLIGQEGKGLGIGLSTLDGGRIGVAAQGLGIAEGAFEIAKNYMKERVQFGKPIYKNQYLGFKMAELAVEIEKARYLLYKAALDKDEGKPYSVSAAMAKLACTDLAMKVTVEAVQMLGGNGYMKDYNVERMMRDAKITQIYEGTNEIQKMIISGSLFK
>NC_022777|459142:532262|513991_515746_+|WP_023437355.1|DBSCAN-SWA
MKRNFIITLMAFMLLTGFVISEKVHASNISHERYWGKDRYETSIKISEKGWQNQAKYVVLASGQGYADALSASPFAKLIDAPILLTKGDKLEEKTLQEIKRLNPSKVYIIGGEGSISQHIEDEIKSKISNDVERFKGEDRYETSMKIAQRFPNKEKVILASGEGYADALSAAPIAAINSMPIILTPRDRLPKLAEDYLKKDEVKTIYIIGGTASISDTIEKELPSSIRIYGKDRFQTNAEIIRNFPLDFDYKNVYITLGAGETGNEFADALTGAVVAARDRAPVLLTGKNLNSNTKAISNEVLFPHTKFKVLGGVNNVSDKLVEDIKVTITDNFLNKDKEYTRNTLGNAMISEGGIKLKNSKIKGNLYVESDDVSLKNVEVNGTIYLDPGRKGQTRLEKVKADKIIVLSARNEGNGIYLEDVDANLLEIKSGTKAKISIRRGTDLKKIKVLANTLIENYQGDYKEIIIPKTPNYKELELTGSFTENIIVEGQTELKTIDGAYVTDVLIKTDKEDVVILDGKFDDVKVYTAADIKITEKASARIFGETIEAQTKAEIYVPKGADVNIRRIRPHNITGDGKNNALN
>NC_022777|459142:532262|463800_465762_+|WP_023437314.1|DBSCAN-SWA
MKTFDKIIKGRKNIIIILTFLFQILLCSKTVLAANVDVIDNVKITNEKGVVQGGYRPGDRIRIDVDWSIKSETKAGDTFSLKIPKELRGFNGTIQLRDKEGRNFGTGVGKGDVITFTFSDIVEKLENISGFFYIQSEIKYIERQGEIEVPLVFEVNGKAIKNSIIVDTGSTNSGGSPSKITEMFQKWGRINENDDNIIDWVLRVNYKGEQLYNITITDMISKGHEFVDGSLELYKGYTNHRTGNIDNQTKVPLKYPVNFSSSLSGFKLKLYNESETYTLYYQTKIVDKSISDFRNKATLEAYNKKPIIKEIMVKDFSSGGGASGDLKKYKGKLKLIKQDKTTGELLEGAVFELINDENKVVTTLTTNRKGEAITNEVLGGIYTLKEIKAPKGYKIELESEEITLNFKENKEIKKIVTNKKVTLWTPIEPIKGSIKITKVDKDNLDKVLEGAEFTLKGISEHNKNIKLIGITDKNGLLEFKDIPYGKYTLKEIKAPEGYRIYEGEQEIIIKSQGKVVEVKVENRKSKTSSGSGSRNPDPEKPNSEKPYPEKPETKDPPIDKGDELPPQELDVIKDKLKDKLVDKDKKPSVKVNKVEKKDSSVNILLGKKEVKPKKSVDVLPKTGENGPIFNYVLGLLLIVVGLYLRKRSNIIKE
>NC_022777|459142:532262|473682_474459_-|WP_023437322.1|DBSCAN-SWA
MKNIILKKENGIAEITINRPKSLNALNSETLNELGVAIKDISENDDVKVVIITGAGEKAFVAGADITEMENLNAKQGRELARLAQKVFSDIEHMPQIVIAAVNGYALGGGCELSMACDIRLASKNAKFGQPEVNLGITPGFAGTQRLPRLVGKGTAKELILTTDMIDAEEAYRIQLANKVYESEELMDKARELAQKIMNKAPYAVSLAKAAINDGMNMDTESAYKYEADIFGLCFATEDQKEGMKAFLQKRKSNFKGY
>NC_022777|459142:532262|481749_483012_+|WP_023437330.1|DBSCAN-SWA
MKKIKKVILCLLVINTICILPKSQGTIVKAKENKGDVGQILDLDSLMEKAVENSIEVRNRKSTIESLENGFQDNINGTDSIYERIEKNERFKKLQNKSERTEDEEREYEYYQRNFGIPITGEYELFQMLQSANNTPVLGEFEIFQNKNALEVDKNSVRQRVYEGYRRFLMEMDKLKLAKDKYKNVEDEYKKSEVSYKTGVLSKTDYLAKKAEYLKEKGEFSNIDREFQKYNMEFNKLVGEPLDKKYSSYKKDFNLDKSILKSQDEYIKEALENRMEIKNGEENILVRRFESGSAKAVFSSEHNRERKLAEQKIQNAEDELELKKLDIKMEINLLYNDFEIKLVRLKNLEEGYKQAKKEYDESYKKYSLGMLSRLDFNRKNAEFIESSMDYKEAEREAYVAKLKLEFAASVGTDSKKVFYQ
>NC_022777|459142:532262|495647_496520_-|WP_023437339.1|DBSCAN-SWA
MTQPVKKIAAIHDLSGFGRASLTTVIPILSTMGFQVCPMPTAILSTHTGEFQDYTFLDLTNSMIDFMNHWKSLNLEFDCIYSGFLGSSQQIEIVSEFIDIFGNKNNLKVIDPVMGDNGRLYSTMGGKMVENMRKLIKKADIITPNFTEAAYLLDKNIDDDINECTIKDWLRKLSDNGPKIVIITSVPDINHNQCTNVMAYNKEDDMFWKIGCKYIPASYPGTGDIFTSVLTGSLLQGDSLPIALDRSTQFITTCIKASYGFKYPNREGVLLERVLNTLNMPVIMSSYEIL
>NC_022777|459142:532262|480516_481731_+|WP_023437329.1|DBSCAN-SWA
MNILEGFQSALQSVKSNKLRSFLTMLGIIIGISSVITIVSIGDGAKQFITGEFENIGTNLINMKMSSSPDITIEKRDYFTMDDVKLLKNKISEIEYASPELGLFGKAKVENKMKQASIMATNEDSKKFYNLKMMHGRYLNEHDLESRRAVATIDDRTAKHLFNRVDVVGEKIKFNIGDKNIDLSIIGVFKDPRGNMGDAFGGSNMPGFLTMPLTIVDRLTEDTDIRGISVMLSDMKNADQVSNKMIRLIENKHKNRNKYTAEKGFKELESINKVLGVITMVLGAIAAISLLVGGIGVMNIMLVSVTERTREIGIRKAIGAKTRDIRIQFLMESIILCLIGGSVGTILGILVGKFAGGLINIQIVVSLKVILTAFGFSSAVGIFFGLYPANQAAQLNPIDALRYE
>NC_022777|459142:532262|512192_513785_+|WP_023437354.1|DBSCAN-SWA
MSIITCISFIAFTALVAVLSWYKTRNDDLSSQDGYFLAGRSLTGVFIGGSLMLTNLSTEQMVGLNGQGYKYTMAVMAWEVTSAFALVLMSQVFLPRYLKSGITTIPDFLEERYDSCTRRIISILFLIGYMAAYLPTVLYSGAVVLNSIFNVPEVFGIGQMQALIVTVWAIGIVGSIYAIFGGLKAVAVSDTYNGVGLLIGGFMITVFALIKLGRGSLGEGVNTLITVHPEKLNSIGGADSPVPWTVLFTGMLFNNLFYWCTNQSIVQRTFGAKNLAEGQKGVLLAGFFKLFGPLYLVLPGIIAFHLYGGSLSNQDMAYPTLVVDVLPKSLAGFFAAVLFGAILSSFNSALNSSVTLFTLDIYRPIFKPNSTDEELVQVGKKFGAILAIVSMVIAPLIINAPSGLYNYLQECNGFYNVPILAAILVGFFSKKVPSIAPKIALVFHIILYSISKLVWGHVNFLHVLGFLFPACVVIMLIIGKIKPRENDYVQKYTKQVDITPWSKSKLASIVISVLMICVYVLFSKIGIVGK
>NC_022777|459142:532262|527720_528272_+|WP_023437363.1|DBSCAN-SWA
MDFYSLFLIAIALSLDAFGVALCIGLNNNVDLKYKSSCAIYFGFFQFLFAIIGGYAGFLFNKYIVIMPQVVGGVIICIVGIIMIKEGIENEDDCKILKPGMNIILGISVSIDAMVVGFTALNKIQSGLLILRDTLFIGVVTLFVSILAFITSKYLKKIDVIGKYADYIGGIILIFFGLKMIFF
>NC_022777|459142:532262|510050_510947_+|WP_023437352.1|DBSCAN-SWA
MFNKDKVKIGIAPIAWTNDDMPELGAENTFEQCISEMALSGFKGTEVGNKYPRDTKVLKKALELRDMQIASAWFSAFLTTKPYEETEKAFIKHRDFLHEMGAGVIVVSEQGHSIQGEMEIPIFKEKPIFTEEEWNNLAKGLNKLGKLAKEKNMEVVYHHHMGTGVQTTEEIDKLMEMTDPTLVYLLYDTGHLVFSGEDPIAVLRKYINRIKHVHLKDIREDIVKTVKQKKMSFLQAVKLGAFTVPGDGNIDFKPVFDILAENNYEGWLLVEAEQDPARANPLEYAIKARKYIQEKAAI
>NC_022777|459142:532262|487030_489958_+|WP_023437335.1|DBSCAN-SWA
MNFFKIIKNDIKNILSNKMLAITLVVVMLLPLLYGGLYLAALWDPYGQTESIPVAVVNLDQGTEKEDIFYRFGGDLEDALKENDDIGWQFVETVKEAEEGLMGDKYYAMLVIPKNFSQQVMDVEHGKLKKPKVVFKANKKKNYIVGLIADKAAGAVEKGIKEKTGAKFTEIIVDNLETLRDGLETAADGTYTMKDGITELKDKIPSLDSALGKIEDGSSTLEEKLGDAEDGGNKLKEGIGTLKSKVPDLLDGIDRLHNATVNLNENVKDAYDGSTRLRDGALGLNDKLPDLSDGVDSIFEGSTALKEGIGQVDDKMPDLIDGVQKLRDGARDLRNGISKVTKGIEDKLGDEKDKKKKSEEEESKKPKKKLDEQVVNKLVEGIAPAIPIAKGKIPQLAGGLEQVNGGLKVLESMASSPEQKQIMQGLINNIERDKEDINSLLEAFKLIETGEDGKVKYGLLQLSKLLVRKDIDGEYCVIKNTIDDLNNVEKLAKQIASGYGVDIEVVPVEKLPPQLIPLKQLYMGANQISTELNKIYSNPKLKVLKDGLNMYQVMYQMESYDRTIIPKLTGIIDGLNALYEGSNKLYNGLDTLYDKTIGLQDGIGLLYNGSKDLNNGADKFQGIVPVLVGGVSQLTDGTRDLSDGLFKLEKGTGTLSDKVKELNEKVPDMQDGINLLYDGTFDLTDGLSKLKEASGKLNNGVSNLKNKMPDLQDGVDKLYEGSSTLNSSLAKGGEKISDRLVRSSKLMGDFVSNPINLDDTPIFDVDKYGIGLAPNFVSLGLWMGALMMFFLITDKVQEEKVGKARNASIMLGKYLLCGAIGTIQAILLSLAVIKLGLNPVSNLTYIGFNIFLSWVFVAVAITLVFLLGDVGRLLLVIILLLQLTSSGGTFPRELLPKFFQVVNPYLPFTYSISGMREVILGPNPAVLRRDIAVLTAVLVGSLAIGMAFKGRMDDFKRKKSQEKNQIIDEGSSISH
>NC_022777|459142:532262|492216_494304_+|WP_023437337.1|DBSCAN-SWA
MNKKKITIVTAVALTCALSFSVLASYPNEDKASSKGGVRRVFASASLNENNIKFPDKNLDIAIREATNKEPDATLTKNDFKMVTKLNLKSKNIKDISGLEFFENLQSLDLSNNEIKDLEPLSGLKYLKELTLYKNKITEVKALDGLKNLEKLNLRDNKVKNIEGLKGLEKLRELDLGKNSVFQPKPLKDLKNLRILNLESNGIGNAEDLEELKQVEHLILSNNTVDDVEPLLTLTNVNKLYLDDNPVTHVGKLKDMPNLKRLNINNDSIEDLAELKKFKNLQWLKFKNQEMVLDNKKLNDLLVDSNKEVKFADKNLEFAIRDKIEKPKGAIKKADLQRVTQLDLWDKNVTNLAGIENLIDLRVLNAGKNNISNLEPLKSMDNLENLYLTKTKVISLEPLRGLTNLKALVINETSVSDLTPIKNLINLERLTLGDNKLVSLAGIENLVNLESLDINKNNVSNLASIRGLTNLKSLNINENNVTDLSIVTNLKNLERVSLNKNGVTSLGALAALPELEWITAKENGLTSTVGLQNALKLKELFLDSNQISDLSSLANLTSLETLSLRTNNISDLGSLSDLTRMKNLYLHKNNIGSIAPLAGMENLTRLYVGKNHISDISAVANMKNLKTLSIGENMVFNIGPVSGLQSLETLDVADNFITDASPAIGLPNLKDIMLLNTKVPEAQINAFPDSVTVTK
>NC_022777|459142:532262|500207_501986_+|WP_023437344.1|DBSCAN-SWA
MNKKRTFLNLLATITTSVFLSGVCVESKVSAATYSKSERIWGKDRYETAVKISQNGWKDGANCVILSSGEGYADALCAAPLAKIKDGPILLTKKDTLDSNTLEELKRLGVNRVYIVGGQGSVSKEVENKIKSETNSKVERIEGKDRYETSIKIAEKLGTVNKNNQPKELILASGENYADALSAAPVGAIREIPIILTKSSELPSETKEYIKKCNANKSYVIGGQASISDSIKKSLPRSKRIYGKDRFQTNVAVAKAFPSDFEFKKPYVALGAGSTGNEFADALAVSALAAKNSAPVILTGKNLSDSTETLAKENFLPSSKITVLGGINNVPEKIVQDIRAVAELMNEEEGLYDQNIEGSAVITAKDVTVNHITINGDLYIEEKDAEIVKVKVNGTIFINPGENGECKLEDVEADKVVILSGTERGIFFKDVRANELELRNKNKTRVVLEELSKFNKTEVLTATILQNVVGSFGEVTIKDTLKDKDVELHGSFHEKIVLEGSVTLNAFPANYIEKIEVKTEKGEDIMLDGDCREVEVYSGVNIKVTKNTKGDIIAKSLEAENCATIDMPKNLDIKVKNFKLDNITGEGKEQFM
>NC_022777|459142:532262|474746_475166_+|WP_080751365.1|DBSCAN-SWA
MTKDVYVCGVELTTDILGGKWRIMILWYLRKKSLRFGQLKRSLKGISEKVLSQELKQLTELGLIDKKVYYQKPLKVEYSLTNYGRTFLPILYSIFEWGAHYAEIFNIPLIIDDATIDEVLNEKERFLVEYKNNKLESVN
>NC_022777|459142:532262|486395_486812_+|WP_045923572.1|DBSCAN-SWA
MSQKKNRKRKQRKKNQLQKSQKKKPEEEKPSKEESVKQGFIGVSKIETTSTKEIKVVFDEKVVKSSAEISIYYEMDGKDLTYDNCDIKLLDDEKTVVITFKEEFKKGTKKKFKVKEGYIQAKNTGYPAQEKEVELIFN
>NC_022777|459142:532262|459142_460033_+|WP_023437311.1|protease|DBSCAN-SWA
MDQAKSYIFRIVRDSKNDENYVVSNIKADNPEDLNRILKAEMENYPNAIEFKVKTEKIQETFNSLESAYDDYFKENRTKYPNIKYGIKLKSPDGKYNPTDEYVDVIFEAKYVVYGTEEEIPAEKLRSYEEEAEKIAKDFVNKEIGGKNLSDAEKALKINDYLVKRAAYHHEGVNTYYVEDHIAYGVLSDRKKGVCESYAKAFQLLAEKSGLTSIYVTGQGKNPNKDKGEAHAWNMVKIDGQWYSIDTTWNDIGEGSRYDYFLKSDDDMKATHTRSTDFNYPTGNGTKDFVAELKLK
>NC_022777|459142:532262|509005_510019_+|WP_023437351.1|DBSCAN-SWA
MINLGVVGFGRIGKVHAESLTKYVSNVSLKAVADPFMNEEGINCAKSMGVKNVYKDYKEILNDPEIDAVLVCSSTDTHSKISIEALKSGKHVFCEKPIDHDIERIKEVLKEVEKSNLKFQVGFNRRFDHNFKTIKNTVEAGKIGEPHIIKITSRDPEAPPIEYVKVSGGIFLDMSIHDFDMIRYLSGSEVEEVYAIGDALINPDIKKEGDVDTAIITLKLANGALGVIDNSREASYGYDQRAEVFGSKGSVQISNDANSTAVVSTKDGITGEKPLYFFLERYMQSFADEIKEFVKAIEEDKEVPVTAIDGLNAVLIGIAATKSLKEGKAVKISEIGL
>NC_022777|459142:532262|522495_523935_+|WP_023437359.1|DBSCAN-SWA
MKYKKDKINTFKLVILLLVISAINIFPGNKVGAAEITTKRFNGRNRYETATKICEDGWNEESDWAVVVNGDNFVDALSVAPLAKKHNAPILLTNSRVLNVYTSMQLNRLKVKNVYVIGGKGVISQNVEDGIKAKGIKVTRLGGKDRYDTALEIAKKLGRPKQIAVINSTSFYDGVSIAPIAALKQMAVIPVAKNDMPKSIEKFLKSNRRAEQIYVIGGQDHISNKIFNKIPNAIRVGNGDIYKRNIDIINAFQNELDFGNVYVASSRDFADALSASALACQSSSPIVLAGGNLSNSTKNFMKSKIINNVSILGGSASVSYNTEQILKYLPLRVADTENIRKEIWQNESFTPPPTIVVTANNGNMEEVSVTWNLTRVDTTKPGIYSFVGEIDGYNRQVDLILIVRPLPVKIDDINKEAKSRERFVLPEKVEVEMSDGSRSELPVIWDYGTKQSNKSGVYVFYGTVEKYDKKVKLTLTVTE
>NC_022777|459142:532262|483024_484221_+|WP_023437331.1|DBSCAN-SWA
MKKGNITALILATLLFANSSTVVFAMNNAENNSREIENKEEIKVITILGKDNEEELNLNMKEVMEKLEKDNSELKLMEGKINLLNRLYDRDLTLSQSIDNDRDISINYNNVSFRRQQMLNFRQSALNVKSARKDKEDKVKEIKRELERNYLNVLNCRRDIKNTEETLKNLDMQIEKLQRYIDEGKASSTSIEPLKVQKTQLRSSLNLPKLQEQESLLKIKQYLGLDQTKNIKLNLEYANKEFKLYNPENIDKIINDSIEKNFGLYKMNEGLEFLKVERHIYEKYGRNIEVESTNLDIRMKDMQNSIEDYKLNLRVNFWSAYYKLKGTEEAVDVAKANLDHSKMKYEETKYRFDQGLEDKVQLESAKLDFEKKKIEEEKAINEYMITVQSFKDTLGIGE
>NC_022777|459142:532262|526572_527565_-|WP_023437362.1|transposase|DBSCAN-SWA
MPRHTRIKLSNGVYHIIMRGSKESPLFRNNYDKLKFLKILQKYKNIYFFRVFSYCLMDTHIHLLIHSNNADISDFMKSINQSYAQYYNLKYDRIGPAFANRFKSYLAKSESHIILLSSYIHNNPKDIPKYKNSLDNYRFSSFGIYTGKLKDAFNLIDYSYILCHFNSDILLSKQQYANFVGNDIDLTDENINISKKYYITKNYINTNVNFPCYENNLNLLNFYKFINDENLLPRNICPNKIINFVCSMGNIDPTHLNIKYNRRVANLRCLCTLLIRSFSNFKIKEVGTLFNNFTPSSLSQQCNRGYELISQNKYFETIFYKFMVKYTNPT
>NC_022777|459142:532262|466035_466911_+|WP_023437316.1|protease|DBSCAN-SWA
MKKFFRGFLTIVFLFSCSNICYAKNISSNIEFINKNISAVNSLCASTNTQNCRQASSIQQLKPLLKTAMENREVNIVIKYTGMDCYNKRNVDINKIKDLTEKILNEDHYLKYSIRGYRIGTSGYYGNVNIKFNFDYLTTKAQEEYVDKRVESILSDIITDDMNDYAKEKAIHDYIVANVQYDTSLQEYSAYSALAKGKSVCQGYSLLMVKMLQNVGIKSIIVESIPMNHAWNMVYIDNKWYHVDATWNDPIPNVPNRVLYDYYNLTDYKISQNINGKMHVWNRYEYPSTKH
>NC_022777|459142:532262|476519_477833_+|WP_023437325.1|DBSCAN-SWA
MDWENIYKSKLLSPKEAVLKLKSDDNVAIGHAASEPRLLMNALVCNKESFRDLKLYQMIALEKSECAKKGMEKHFSYNSLFVGGGSREAINDGRADYIPCFFSRIPRLFRENYIKLDAALIQVAPPDEHGFCSFGVSSDYIKPAAECAKLVIAEVNDKMPRTLGDNFIHVSDIDYIVENSREILELKPSNIGDIEKAIGENCASLINNGDVLQLGIGAIPDAVLLFLKDKKDLGIHSEMISDGVVDLVKAGVINNKKKTLHQGKIIVSFLMGTKKLYDFVDNNPMVRMYPVDYVNNPVVISKNDNMVSINSCIQIDLMGQIDAETIGFTQISGVGGQIDFIRGAGLSKNGRSIIAIPSTVGNGKISKIVPLLDKGAAVTTTRNEVDYVVTEYGIARLKGKNLRDRARELIKIAHPDFREELKLEYKNRFKEEFKRIG
>NC_022777|459142:532262|529361_529760_+|WP_023437366.1|DBSCAN-SWA
MEFKSLILIEKDIESNEFIREMDSYELGEGAMYIEKFYYDGGFVNIVFNIDEDMEDWKYNSILDYFNTEIFEKYICSIEEVEGEYNPTWIIKFKYTDNFDLMSEKLEDICEEIYNQIKIVMEFVEKNRDQLI
>NC_022777|459142:532262|506221_507010_+|WP_023437349.1|DBSCAN-SWA
MLEKLKELEKGHNILVESNGKHSEMMMDIGICKLETGQEEFFIEKNKESSFLLLLGKMVIEWEDKEQEIERNSLFDEDPWCLHVPKSVNVKITALTDAEVLVQKTENSRVFPCKLYSPKECRSDVFGHGVWNDTARRVVRTVFDYSNAPYSNMVTGEVITYPGKWSSYIPHHHPQPEVYYYRFNKPQGFGCAFIGEEAYKITDNSIATIPGGLVHPQTSAPGYAMYYCWMIRHLENNPWTDRINEKEHEWLLESDVKIWPEK
>NC_022777|459142:532262|503113_504268_+|WP_023437346.1|DBSCAN-SWA
MAYKINIPGNIIYGKNALKESSKNIKELGGKALIVTDKIMVEIGNVKKVSEVLDDIGIKYEIYDGINSEPTDVMVDKGIEIYNNSHCDFLIAIGGGSPIDTSKAIGAMVTNLGNINDYMGKIIENAPPSIVAIPTTAGTGSEATEFTIISNTKDNIKMLLKGKSLIPTLAIVDPQFSITVPQNITAATGIDALTHAIESYTSKHANSFSDTFALSAVKRIFNNLIKAYKDGKNFEARNEMALGALEAGIAFNNSSVTIVHGMSRPIGALFKVPHGLSNAVLLPKCLEFAIQGQEKRFADIAKAIEICKEETSDKEAAEKLVKEIESLCKDINIPTLEECGIEKNEFYEEINKMAEDALNSGSPANTRRQPTKEDIVNIYRQLYI
>NC_022777|459142:532262|485272_486490_+|WP_023437333.1|DBSCAN-SWA
MFAKKSKKAIISTLITSFIFAPSVTGISKVGAKAEVVRMPGLNRFITAQNVAKQSFGTAENVILVNGLGYADAVSAAPLAKILKAPILLTDASKKPSVDLLETLSKLGTKKVYIIGGEGVVTKTLEIELAKSYAVERIAGAPKDGRYGTNAAVAKKVIEKTDAKGGILVSAEGYADALSVASIAASKGYPVLFANREEMPKIVKDIASNLNVKAVGGEGVLPNKVLESVNAKRIAEGKDRFESNLKVLDYYKDDLNFKNIYIAAGGDDSRYKFADALVASAVAGKDGAPLVLNGLGANDENRKAANEYIKDNMKKDVKVTIVGGGASIDGFIESELLAKAQKINEDSGEPESEDIVEGDKQEREDSEDTKEPTKDESEKEPEKETEKEKPTTEEPEKKARRGKTI
>NC_022777|459142:532262|524376_525438_+|WP_023437360.1|DBSCAN-SWA
MLRKRYFKFLGAMVLSTVLVTTVNTGIVKAATLDRLGGLDRYNTARQVAEGVFSQCENVILVNGQGYADAVSATPLAKKLNAPILLTEADKLTSGVLDTIKKIGAKNVYIVGGEGVVKPSIELTLKSSGLKVNRYAKSGGNRYDTNAVVAKEVIMKTGAKKAILVNGQDGYSDALSVASIAAKLEIPVLISNSKKMDKEVKKVVDDYKLEIMAVGGTAVLPDTVVKSVNGKRVAQGQNRYKTNINVLNYFKSNLSFNKMYVASGGNDNIRNFADALVASAAAAKEGSPLVLSGNSASSTDIAASESFVRNNITKDSKITLIGSTGVLSKEIENKMRKIAEYASEGDLEIIGIE

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023437311.1|459142_460033_+|protease	transglutaminase/protease	NA	NA	NA	NA
WP_023437312.1|460849_462832_+|protease	transglutaminase/protease	NA	NA	NA	NA
WP_023437313.1|463053_463368_+	hypothetical protein	NA	NA	NA	NA
WP_023437314.1|463800_465762_+	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_023437316.1|466035_466911_+|protease	transglutaminase-like protease	NA	NA	NA	NA
WP_023437317.1|467028_467454_-	DUF2935 domain-containing protein	NA	NA	NA	NA
WP_023437318.1|467716_469423_+	methyl-accepting chemotaxis protein	NA	NA	NA	NA
WP_023437319.1|469504_470809_-	GntP family permease	NA	NA	NA	NA
WP_023437320.1|470919_472059_-	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_023437321.1|472092_473640_-	acyl CoA:acetate/3-ketoacid CoA transferase	NA	NA	NA	NA
WP_023437322.1|473682_474459_-	short-chain-enoyl-CoA hydratase	NA	NA	NA	NA
WP_080751365.1|474746_475166_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_023437324.1|475519_476329_+	mechanosensitive ion channel	NA	NA	NA	NA
WP_023437325.1|476519_477833_+	acetyl-CoA hydrolase/transferase family protein	NA	NA	NA	NA
WP_023437326.1|478023_478479_+	winged helix DNA-binding protein	NA	NA	NA	NA
WP_023437327.1|478475_479789_+	biotin/lipoyl-binding protein	NA	NA	NA	NA
WP_172645118.1|479806_480520_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.1e-34	36.8
WP_023437329.1|480516_481731_+	ABC transporter permease	NA	NA	NA	NA
WP_023437330.1|481749_483012_+	TolC family protein	NA	NA	NA	NA
WP_023437331.1|483024_484221_+	TolC family protein	NA	NA	NA	NA
WP_023437332.1|484327_485152_+	hypothetical protein	NA	NA	NA	NA
WP_023437333.1|485272_486490_+	cell wall-binding repeat-containing protein	NA	NA	NA	NA
WP_045923572.1|486395_486812_+	Ig-like domain-containing protein	NA	NA	NA	NA
WP_023437335.1|487030_489958_+	YhgE/Pip domain-containing protein	NA	NA	NA	NA
WP_039260613.1|490058_492152_+	leucine-rich repeat domain-containing protein	NA	NA	NA	NA
WP_023437337.1|492216_494304_+	leucine-rich repeat protein	NA	NA	NA	NA
WP_023437338.1|494621_495581_-|transposase	transposase	NA	NA	NA	NA
WP_023437339.1|495647_496520_-	pyridoxamine kinase	NA	NA	NA	NA
WP_080751363.1|496534_497476_-	radical SAM protein	NA	NA	NA	NA
WP_023437341.1|497705_498143_+	hypothetical protein	NA	NA	NA	NA
WP_023437342.1|498342_498792_+	VanZ family protein	NA	NA	NA	NA
WP_023437343.1|499005_500169_+	N-acetylglucosamine-6-phosphate deacetylase	NA	NA	NA	NA
WP_023437344.1|500207_501986_+	cell wall-binding repeat-containing protein	NA	NA	NA	NA
WP_023437345.1|502101_502869_-	DeoR/GlpR transcriptional regulator	NA	NA	NA	NA
WP_023437346.1|503113_504268_+	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_023437347.1|504330_505176_+	class II aldolase	NA	NA	NA	NA
WP_023437348.1|505195_506215_+	5-dehydro-2-deoxygluconokinase	NA	NA	NA	NA
WP_023437349.1|506221_507010_+	5-deoxy-glucuronate isomerase	NA	NA	NA	NA
WP_039260614.1|507027_508962_+	3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing)	NA	NA	NA	NA
WP_023437351.1|509005_510019_+	inositol 2-dehydrogenase	NA	NA	NA	NA
WP_023437352.1|510050_510947_+	myo-inosose-2 dehydratase	NA	NA	NA	NA
WP_023437353.1|510979_512005_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_023437354.1|512192_513785_+	solute:sodium symporter family transporter	A0A240F3J2	Aeromonas_phage	7.0e-46	27.7
WP_023437355.1|513991_515746_+	cell wall-binding repeat-containing protein	NA	NA	NA	NA
WP_023437356.1|516040_517753_+	cell wall-binding repeat-containing protein	NA	NA	NA	NA
WP_023437357.1|517870_519532_+	zink-carboxypeptidase	NA	NA	NA	NA
WP_023437358.1|519839_522455_+	cell wall-binding repeat-containing protein	NA	NA	NA	NA
WP_023437359.1|522495_523935_+	cell wall-binding repeat-containing protein	NA	NA	NA	NA
WP_023437360.1|524376_525438_+	cell wall-binding repeat-containing protein	NA	NA	NA	NA
WP_023437361.1|525481_526321_+	SLAP domain-containing protein	NA	NA	NA	NA
WP_023437362.1|526572_527565_-|transposase	transposase	NA	NA	NA	NA
WP_023437363.1|527720_528272_+	manganese efflux pump	NA	NA	NA	NA
WP_023437364.1|528348_528762_+	transcriptional repressor	NA	NA	NA	NA
WP_023437365.1|528876_529206_-	hypothetical protein	NA	NA	NA	NA
WP_023437366.1|529361_529760_+	hypothetical protein	NA	NA	NA	NA
WP_023437367.1|530008_531067_+	HD-GYP domain-containing protein	NA	NA	NA	NA
WP_023437368.1|531224_532262_+|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NC_022777|1119025:1169373|DBSCAN-SWA
CATGAATAAACCTGAAATATTAGCCCCAGCAGGTAATTTAGAAAAGCTAAAAACAGCTATATTATTTGGTGCAGATGCAGTTTATTTAGGTGGAAGCAAGTTAAATCTAAGAGCTTTTGCTGATAATTTCACCGATGAAGAGCTAATTGAAGGAATAGAATTTGCTCATAGTAGAGGAAAAAGGGTATATGTAACAGTTAATGTTTTTCCTCACAATGAGGATTTAGAAGGGTTAGAACCCTATTTAAAGGATTTAGAAAACATGAAAGTAGATGCCATTATAGTATCAGACCCTGGAATAATAATGACAGCTAGGGAAGTGGCACCTAAGCTAGAAATTCATTTAAGCACTCAAGCTAATAATGTTAACTGGAAATCAGCTATATTTTGGCATAAACAAGGTGTTAAAAGAATTGTTTTAGCAAGAGAATTATCCTTTGAAGAAATAAAAGGAATAAGAGAAAAATTGCCGGAAGATTGTGAGTTAGAAGCTTTTGTACATGGATCTATGTGTATGTCCTACTCAGGAAGATGTCTTCTTTCCAACTATATGACTGGAAGAGATGCTAATAGAGGAGAATGTGCTCAACCTTGTAGATATAAATATTATTTAATGGAAGAAAAGAGAGAAGGACAATACTTCCCAGTATTTCAAGATGAAAGAGGAACTTACATATTAAATTCTAAAGATTTATGTATGATAAAACATATACCTGAGTTAGGTAGATGTGGAATAAATTCTTTTAAAATTGAAGGAAGAATGAAAAGTTCTTATTATGTAGCTTCAGTAGTAAAATCCTATAGACAGGCATTAGATGCCTATATAGAGGATACTAAAAATTATAAATTCAATGAAGATTGGATGAATAATTTATTGAAAACAAGCCACAGAGATTATTATACTGGTTTTTATCTTGGAGATAAAGATAGTCAAATATATGAAACTTCATCATATATAAGAAACTATGATATAGTTGGAATAGTTAGAGACTATAATAAGGAAACCAATGAAGCAACTATAGAACAGAGAAATAAATTGTTTGAAGGAGATTCAGTGGAGGTTCTAAGACCTGTTGGTGATAGCTTCCAAGTAAAACTTGAAAACATTCGTAATGAAAAAGGTGAAAAAATAGAATCAACTCCTGTAGCTCAAATGATATATAAAGCTAAGGTTAACATAGAATTAAAGAAAAATGATATGCTTATTAAAGCTAAGTAAAGTTTATTTGAGGGGGGGAGAAGATTTACTATGAGTAAAAGACCGATATTAATAGGTATAACTGGTGGAACGGGCTCAGGAAAGAGCACTGTAAGTAAAGAAATCTGTAGAAGATTTGATAAAGAGCTTATAGTTATGATAGAGCAAGATTCCTATTACAAGGACCAAAGTCATTTATCCATTGAAGAAAGAGTTAAAACTAATTATGATCATCCTAATGCTTTTGATACAGAGCTTTTAGTAAATCATTTAAAAGAGCTTTCATGTTGGAATAAAGTAGAAAAACCCATATATGATTTTGAATTACATAATAGAAAAAATGAAACAGAAATTGTAGAACCTACTGAAATTATAATAATAGAAGGAATATTAGTATTAGAAGAAAAAGAAATAAGAGATCTATTAGATATAAAGATTTATGTGGATACAGATGCAGATGTAAGAATAATAAGAAGACTTGTTAGAGATATAAAGGAAAGAGGAAGATCTTTAGATTCCGTAATAAATCAATATTTAAATGTTGTAAGACCTATGCATATGCAATTTATAGAACCAAGTAAAAGATATGCAGATATAATAATCCCTGAGGGAGGACATAATAAAGTCGCCATAGATATAATCGTAGGAAATATAAAACAGATGGTTCAAAAATCAGAATAAAAGGATAAAAATACCTCACTTTGACAATAATAAAGTTAAAGTGAGGTGTTTTTTATTCATAAGAAAAGATGTTATATAATACTTTTGTTTTTTTAATATCATTAGGATTTTTAAATTTAAGATTATACAATCTACAATACAAAGATAGAGAAAGATATAATGTTATGGCAAATATGCAGCATTCTTATGTAGAACCTACAAGGGATTTAAATTATAAATTATTGGATTGTAATGGAGATAATTTATTAAAATACAAAGAGGAATATAAAGCTGTTATAATACCTAAAGTATTTGCAAAGCAAAATGGAGAAGAAAACTATAAAGAATATTTAAAAATAATAGAGGAATTAGAACTTTACAATGAAGACTATAATAATTTAGATATAACCTCAAATGCTAAGCATTACTTTACTATAGATTTACCTACATATGAAAAAATAAAGGACATAAAAAATATTAAAGGATTTTATACTTTTAAAAATTTAAAGGTAGACAGAAGTGAAGCTTGGAGCCTAGAAAATATGATAACTACTACGAAAAATATTAGTAGTGGAAAAGAAAAATCATTAGATTCATTGGAAATGACTATAAAAAATAAACTTAAAAATAATAAAAATTATACTATAGAGTTTGAAAAAGATGTAGATAATAATATATTAAATATAGAAGAGAATATACCTAAAAATAATTTAAATGTAAAGTTAACATTGGATAGAAATATTCAAGGAAACATAAAAGAATTATTAAAAAGTAAATATGGAGACTATGAACAAATAGGAGTCATTTTAATGGAAAGTAATAGCGGGAATATAAAGGCTATGGTACAAAAGGACGATACTTTACCCAATATAAATATAGGGGCAGAAACTTTAAATGGTTTTTTTCCAGGCTCTATTTATAAAACCTTAGTTATGGAAACTATTTTGGAAAAGGATAATGATAATGTAAATAAAAGTTTTTCTTGCAAAGGATTATACGAAGATAATAACAAAGGTATAAATCACGGTAGTTTAAATATAAATGATGCTTTTGTGGTGTCTTGTAATCATATATTTTCACAATTGGGCATAGAATCAGGTTTTCAGAGTATACATTCCCTATCTAAGTCTCAGGGACTTTTAGATAAGGTACTAAATTTAGATAGAGAGCAAAGTGGTAAATTTGAAATAGAAGAACCTAAAATGGAAAATGGGAGTTTAGGCCTTACTGCTATAGGTCAAAATATAAGAATTACTCCCATAGAGGCAATATCTATTGCAAATACTGTAATAAATGAAGGAATATATATAAAACCAAATATAATAAGTGTATATGTAGATAACGCTAATAAGGTAGTAGAGAAAACAAAATATCAAGGTGAAAGATGCATATCAAAAGAAACAGCTTTAAATGTGAAAAAGGCTATGAATGGAGTAGTTAATAAGGGAACTGCTAGAGAAGCTTATTTAGAAGATATAGATATAGGTGGAAAAACTGGTTCTACAGAAAGATTAGAGATAATAAAGGATAGGAATGGTAAAAGTAAAAGAATTAAATATTCTGATGGATGGTTTATTGGATTTTTTAATAAAGAAGATAAATATTATTCTATGGTGGTATTTGTAAAAAATATAAATAAAGATTCTGAAAGTGGTGGAAATACTGCAGCACCTATTTTTAAAGATGTAGTTAAGATATTTCTAGATAAAGAACATTAATACAAGTAAACGTTACTTTGTTTGATACTTAAAAGAAAATTTATATAAAATAAGAACTAAAATTAGTCTCCCTGAATATTATAATAATAAGCACTATTTGGAGGGACTAAAAGTGTATATGTTTGATTCAATAATAAACATATTAGGTAGCAATATACTATTGACAGCCTATGTTACAGGTAATAATTCTTTTCCAAAACCATTAAAGGCAGAAGAAGAAAAATATTATTTAAAACAATTGGAAAAAGGAGATATATCAGCAAAAGGAGTACTTATAGAAAGAAATTTAAGACTTGTAGCCCACATAGTAAAAAAATATTCATTTCCCGGAAAGGATATGGATGATTTAATATCTATAGGAACTATAGGCCTTATAAAAGCCATAGATTCATTTAAAATAGACAGAGGAACAAGACTCGCTACTTATGCAGCAAAGTGCATTGAAAATGAAATATTAATGCTTATTAGAAATAACAAAAAAACAAAAGGAGAGGTATACCTTCAAGATCCAATAGGAATAGATAAAGAGGGCAATGAAATACCCTGGACAAGTTATCAGTCTAGGGCTTAAGTTTAGGAAATATATCTATTCCAAAGGTTTCTCCACGTTTATCCTTAGTATACTCAACCTTATTTACTAACTTTTTCATCAACTCATTTTTCAATTTAATATCATCTGTATTTTTATAACCATCTAGTAATTTTTGAAATTTAATTACATCTTCTTCTTTTATTACTTTTTTCTCTTTATTTATTATATCATTTATTTTTTCTATTCCAGAAGAAGTTTTAGTTATTCTTTCCTCTATATTTTTAGACCTTTCTAAAAAAGTATTTTCATCATATATACCTCTTTCTAAAAAATCAAACAGTTTTAATTTTTGTTCATTCAGTGCAGCCAACTCTTTTTCTAGTATATTTACCTGACGTTCATAGGGCTTTATATTAGAGGTTTTATTCTTATTAGATATATTTATCCTATACTCATTTAAATAGCGTTCTAAGGCTTGGACAATAGCTTTTTCTGTAGAATCATATCTATTACTGATATTATCACATTTATTATTTCTACATAAAAGCCTATCTATTCCTTTTAATTTTCTCATAACCATTTTAAACTTACATTTACTACAAATAACTATACCCGCAAGAGGATTAGCAGGACCATTTACAAGTTGGTATGGGATATGGTATTTATTATTTAATATTTCCTGTGCTTTATTCCACATCTTCATACTTATTATAGGTTCATGCTTACCATCTACAACTATCCATTCTGATTTATCTCTTGTTCTAGTATCCTTTACTTTATTAGGATTTTTAGATTTTTTAATTTCTTTCTTCTTCCAAGTTACTTTACCTATATAAATAGGATTTTTAAGAATAAATAAAACAGAACTTCTAGAAAAATTATTATTAAATTTTGTTTTATATCCTAAGTTATTGAGATGTTCTGCAATAGACCCGGCTCCATTGCCTTCTGTATACAATTTAAAAATTAATTTTATTATTTCACATTCATGTGTGTTAATTTTTAAAGTTCTAGATTTTTTTATCCAATGTATATCATATCCTAGAGGTGGATTAGTTGCTATATAATTACCATCTTCTACACTTCTAACTCTACCACCTTGCATTCTACGATTTATCATCTTTAATTCTTTTCTAGACATGAAGGCTTCAAATTCAGTATACTCTTCATCAAAATCATCAGATAAGTCATAGGTTTTCATAGGTGTAATTATTTTAGTATTAGATTTTTTAAAAGTTTCTAATATAATACCTTGGTCTTGCATATTACCTCTGCCAAGTCTTTGCATGTCCATAACTAATACACCAGTATATTGTTTATTTTCAACCTCCTTTAAGAGCTCTAACATTTTAGGTCTAAAAAATAAACTTTCACCAGATACTATTTCTTCTTTTATTTCCACTATGTTTAATTTTTTCTCTTTAGCAAACTTTAATAATGCTTTTCTATGTTTGGATAAGGTTTCACCTTCACCTAAAGTTTTTTCAAGTTCTTCATCCGCACGTGATTTTCTTAAATAAATACAAATTTTATTCAAAACATCACCTCATTAAATATAATTATTTAATCCTTTTTATAATTACTTCTTTATGTTTGGCAACTTCATCTTCAATTCTATTAAGTTTCTCTGAATTTTGTTTATAACCATCAAATAAAGCTTCAAGTTTTTTACCATGGTCATTTTCAATTCTTATTACAGTTTTCTTAACTTCTGATATTTCACTTTTTAATTCAGTGCATATTTTTCTTTGACCTTCTTTTAAATCTGCATACATTTTTTCTTGGCTTCCCTTTAGGTCTATATACATTTTCTCTATTAGTTCAAATATTTTTTCATTTTCCATAAGTATCATCCTTTCTATTATCTATTAGTAGTTACTTTACGTTGAAGATTAAATAAAACTTTCTCATTTTGACTTTCTTTATGAGTTAGATATTCAACATCATCTTTAATTTGATTGAGGGACTCAATGGATTCTGTACGGAATTCAGTGAGGTCAGCAGTTTGATTATATACAGCATTAACCTTTTCTTTAATTTCTGTTATATCAGATTGCATTTTTTCCTGGGTTTCTTTAATTCCCTTAATCTCACTTAATATTTCTTTTAATAAGTTTTCCATAAATAAAACACTCCTTTATATAATATTTTAAAATATTTTCATAACTCCTAAAGTAGGTTCAAAGTATATTAGATAGTTATCTATTTCATAATATAAACCGTACTTAGTTTTATAATAGTTTATTGCTTCTTCTAAGAATTCTTCTGTAACATTTAAATAATCTGCCAAAGTATATTTATCCCTAGCACCATTATTATAAGCATTAACTAAATCTATGATTCCTATAAGTTTTTCATAACTCCATCTTCTAGCTCTGACTTCTTGTTTAAGATTTACAATTTTTGATTGGTCAGTAATATCACCTACAGTTGTATAAAAATGCCCAAGTTCTTCAGCTAGTATACAACGCTTCTCTTTATTAGTTGTTAGATTCTTATTAATAGCTATTCTATTTCCATAACATAAACCATCTTTAGTTTTTAAATCTATTTCTTTAACCATTATATCATTGTTAAAAGCTTCATCTAGTAAAGTATCATAGCTCATATAGTCACCTCACATCCAATTCAATAAAATCCTTATATCTGCTTATTTCCGTAAGTTCCTCAACCCTTTTAATAGCCTCATCTTTTCCAGTTTCATTCAGTTTATTGAAGTTTGTTAATAATGTTGTTTTTTTAGTATCTTCTTTATCGTTATCAGTTACAGATTCTTCCCATCCCATTAAATATGCTGGAGAAACATTTAAAGCTTTTGCTAAAACACCTAATTTATCTAGTGGCATATTTTTAATAGCTCCAGTTTCATATCTTTGTAATGTGGATTTACTCAAACCAGTCTTATCTGCTAAGTCTTGATATGATAACATAAGTTCATTTCTTCTGGTTTTAATTCGGTTAATTATTTCTTTCATGTTTTGCTTGTCTGAAACATTTATCGTAGTAGCTTCGGAATTGATAGGGGTTTCACCATTCAGTTTTTCTAGGGAGATTCCTAATCCTTCAGATAATTTAAAGGCAACATCTAAAGATATATTTTTAGTTTTCCTGGATATCATACTTCTAAGAGTTGAGTCTGATAAACCGGTAGCTCTTGAAATATCGGGAATAGATAAGTTATTTTCACTCATAATATTTTGTAATATTTTATAAAATTCCATATTATACATCCTCCTTTAAGTACTATTATACTACTTTTTTCACGCAATGCAATAAAAAAATAAAAAATAAGGGTTGACAAATCATGCAATGCGTTATAATATTAAAGCATTGACAACGCAATGCGTTATTTGGAGGTGAAGAAATGAGACAATCAAATGTGATATTTGCCAATTTAAGAGCAGAAATGGCTAGAAAACAAATAACAATAGCTAAATTAGCAGAGGAGGTTGGGGTAAATAGAGACACAATGAGTAGAAAGCTTTCTGGAAAAACACCTTTATATTTAAATGAAGCATTTTTAATAAATAAGAAGTTTTTCCCAAATGAAAATATACATTATCTCTTTAATGAGCTATGTAAAGTATCACAAAAACAAGATAAAAAAAATTAGTATTTTTTAATATCGTAAAGGAGGATGGGAAATGAATAACTTACAAATTTTTAATAACAAAGATTTTGGAGAAGTAAGAACAATAATAAAAGAAAATGGAATTTGGTTTGTAGGAAAGGATGTGGCTGAATGTTTAGGATATAAAGATACAGACCAATCATTAAGAAATCATGTAGATGGTGAAGATAAGCTAACCCGTAAAATTGACGGGGCGGGTCAATCGAGACGAATGACAATTATCAATGAAAGTGGATTATATAGTTTGGTATTAAGTTCTAAACTACCAAGTGCTAAGAAATTTAAAAGATGGGTTACATCAGAGGTACTACCATCTATAAGAAAACATGGAATGTATGCAAAAGATGAATTGCTAGATAATCCAGATTTATTAATACAAGTTGCTACAAAGTTAAAAGAAGAAAAAGCTAAAAATAAAATGCTTGAATTACAAAATAAACAGAAGGAGCAAATCATAGGAGAGTTAAAACCTAGAGCAGACTATACAGATAGAATTTTAAAGAATAAAGGACTTGTAACAATAACACAAATTGCTAAAGACTACGGAATGACTGGAATAGGGTTAAATAAGTTACTACATGAATTAAAAGTACAGTATAAACAAAGTGATCAATGGCTTTTATATAAAGAATATAGTGGTAAGGGTTATACACATTCTGAAACTATAGATATTGTTAGAAGTGATGGCAGACCAGATGTAAAAATGAATACTAAATGGACTCAAAAGGGTAGATTGTTTTTATATAACTTACTTAAAGATAATGGGATATTACCAACAATAGAAGAAGAGGCTGAAAGAGAAGTTGCTTGTAATTAAAAACTAAATTGAAAGGAGATGAAAAAATGAATCTTAAAAATATATCAACAGAAGACTTAATAAAAGAACTTATTAGTAGAAAAAACGTAGAAATTTATAACTGTGGACTATATGAAAAACATGAAGCACAAATAAAAAGGAAGTATACACAAGATAGGAATCCTGTCAAACTTCCTCTTCATTATAAATTAATAGTGGTTGATTAGTATATTACTTTGTTGCTAAATAAAAGTTCCATGTAGTTACAAAGGTTTCAATTACTTCAGAGGAAGTTGTTTTATAGCAAATATATTCATGAATTATACCAAACGTATCATCTTTCGGAAAATTGGAGTCATTTATAATATCTCTGGCTAAATCTCCGATAGGAAGATCAACTTCTTTGAAATTAGTTATCCAAGATTTAAAGGTCCAAGGTATAGATGTAGCATTAGAAGGTATTAACATATTAATCACCCCCTTTCAACAAAATTTTACCACAACGGGGGGGTGGAAAAGAAAGGATATAAAAAAAGACACCTAGTTAAGTGTCTAAAGGGAATGGTTATTTCTAATTTTTTTAAGAATTTTAATATCCATTTCATGGGAGCCAGTAGTTTCTTTAATAACATCAATAGCATCTACAACATCATTAACAGATTTAGAAGTATTTGAAATAGCGAGTTCAATAATGTCTAATCTTTCACCTAGAGTTTTACCGTCTTTATTTTTAGCTCTATCTAGTTGTTCAGAAAAGGATTGTTGAACTTCAGCTAATGTTTTTATATCAGTTTGAATTTTTTCAAGCATTAAAGAGTTTGTATCTACTTGAGATTTTATTTTAGATGAGGTTTTTTCTAAGTCTTCAAAACGTTGATTAAAATCTACATACATTTTCTCAAGTAAATCATAAATTTTATTTTCCATTGAATCAGCTCCTAAAAAAATTAATCGTATTAACATTATACACTACTTGGAGAATTTTATGAACTTGGAAAATTAAAGTTATTAAAGCCACATTAAATTAATAGATATATAAGGAGGTGAGTATTATGGCAGCGATAGTAAGAATTATAGAGCCAGACATCTCAGATGAAGAAAACGAGAGAAACTTACAGGAAGTAATTGAAGTACTAGAAAGAATTGCAGATAGCATAAGTACAAGCAAAAGCACAAAGGATGAATAAGGCTTAATAGAGCCTTTTACCACACTTCTAGAAAAATACAAACACTTCACACTATATTTATATGCACATCTATTTATTATATGCACATTAATATCACCGCAATGGTGAAGAAAACAATTAAAGCTAAAAGCTTAAAAATAGTAGGAGGTAAATAAATTGATAAAACAAATGTTAGAAAGGAGAGTGGGACATTTAAGTAATGACGAATTTAAAGAAGTTATGGACATAGTTACTGATGATATTAAGTTTAATCGCATTAATTTTGGAAAAAGAACAAATAAGATTGAGTTAATAGAAATAGCTGAAAGATCACTACATGCACTTAGAGGAATGGAACTTGAATATGACAGATATGGAAGAGCGAAATATAATCCGTTCATTCATAGAAATACTGGAAAGCCATGGTCTAATACAGATTTAAATTATTTAATTAACTGGTATGACATTATAGGTCCAGATGAAATGAGTTTTGTATTAGAAAGAACTATAGCAACAGTTATGAATAAGGTTTACATCCTTAGAAAGAAAGGAGTTATGAATAAACATAAACGTATTAGAAATTGCAAAAGAGTTAGAAGTATGCATTAAAAAAAAGAGCTGCAAAAGCAGCCAAAATAAAAAACCTAACTTAAATTATAACAGAAAGGAGTATGGTATGTAAATGCTTGTAGCTAGAATTAAACAAATTAAGCAAGAAAGTTATAGTTTATCAGAGTTAAGAGATTTAGAAGATTTAATTATAAACAATATGGGTGAGGATGCCTGGAATGCAATTATGTATTTCATGGAAAAGAAAATAGGAGAGTTAGAAGAAAATAGTGTCTATACAGAAAAAGATATTAAAGATTATGATTTATCACTAACTGCTTTAAGAAGTGGAGTAACAGAGGAGATAGAAATAATTGAAAAATTAATAGATAAAGTAACTAATGCTAAAAGATTAAATAGAGAAACATTAATTAAAGAACTTAATGGTATAAGCAATAGATTATACGATAATGAAGGTTATTTTTAGCTAAAAAGGGGGTTAAGCAATTGGACAAAAAAGTAGCTATTGTTAGATTTCCAAGAGGAAGTTTTAGTCAAGACTATTCTTATAAGACAGATATAGAAAATTTAAAAGAAGGTGATGTATTAGTTGTTGAAGCTAATAACTCATATGCAATAGCCATATTTCAAAGATATTCAGAGGATGAAAATAAAATAAAGCAAGCAACTAAATGGGTAGTTCAAAAAGTTGATATAGAAGCTTTTGAAAATAGATTGTTTTTAGGAGGAGATGATTAATGGACAAGAACTATGAAATTATCCAGGACATTTTATTTAGGGCTATTCAAATTACAGTTAATCAAAAGCAAGATGTATCCTGGGAGTTTTTCTCCCTAAGCAAAACTTTATCAATATCCATTTCATTTAATGGGGAATGTAAAGAGGGGTTAGTAAAAACTTATTCAGTAAAAGTTGAGGATACTGAATGTTTAAAGATTATTCAAGATGAGTTAATTAATTTACAATATGGGAATTTAGATGATGAATTCTTAGGGTAATTAAAAAAATATACATTTAGGAGGAAAATAAATATGAAAATTACAGCAGAATTTAATAGTAGTGAGGAGTTAATAAGTTTTATAAACACTTTTGGTGCTAATGCTTTAAAAGGGATTGAATCTAAGAAGGAAGTACAAGAGGTAGAAGTTAAAGAAGTAGAAGTTAAAGAAGTTAAAAAAGAAACAGTTACAGAGAAGAAAGAAGAGGTTAAACAAGTAGATACACCTAAGGAGGAAGTAAAAAAAGAAACAGTTGTAGAAAAGAAAGAAGAAATTAAGAAAGAGGAAAAATCTAACCCGCTCAAAAATGAGCAAGTTAAAACAGTAGATACATCTAAAGAAAAAATTACAAAGGAGATGATAAGGGCTGCATTTGCTAAATTAATCAAAGCTGGTAAAGCAAAAGAAGCTAAAGACATTACTACTAAATATGGAGCTAAAAAGGTACCCGACTTAAAAGAAGAAGATTACACGGCAATATTAAAAGAAGTGGAGGAATTATTATAATGGCAGCACATGCATTATTAAGTGCTAGTGGAGCAAGCAGATGGCTTGCTTGCCCTCCTAGTGCAAGATTAGAAGAACAGTTTGAAAATGTAAGTTCAGAATTTGCTAAGGAAGGAACTTTAGCCCACGAACTTGGAGAATTAAATTTAAAGCTTAATTTAGGAGAGATTACTAAAAGGAAGTTTAATTCAGAAATTAAAAAGATAGAAGAAAATGAACTATTCACAAAAGACATGCCTGACTATGTGGAAATTTATGTTGACACTTGCATGGAGAAAGTAGCAGAAGCTAAGGCTAAAACACCTGATGCATTATTCAAGATAGAACAAAGGTTAGATTTTAGTGAATGGGTTCCTGAAGGTTTTGGAACAGGAGATTTTGTAATAATAGCAGATGGAACCATGGAAATATGTGATCTTAAATATGGTAAGGGTGTACCTGTAAGTGCAATAGATAATAAACAAATGAGACTTTATGCATTAGGAGCTATAGCAGAGTTTAGTTTTTTATATGATATAGAAAAGATAAAAATGACAATTATTCAACCAAGATTAGATTCTATATCTACTGATGAAATGATGATAGAAGAATTACTTAAATGGGCAGAAGAAGAATTAAAGCCTACAGCTAAATTAGCTTATGAAGGTAAAGGAGAATTTTGTGCAGGGGGTCATTGTAAATTTTGTAGAGCTAAAGCAATGTGCAAAGCTAGAGCTGATAAGAATATGGAGCTAGCACAATATGATTTTCAAGAACCTAATACTTTAGATAACAATGATATAGCCTTTATTCTTAGCAGAGCAGATGAGTTAATAAAATGGGCTGCGGATGTGCAAGAATATGCATTAGAACAAGCTTTACAAGGTGAGGAATTTGATGGATTTAAAGTAGTAGAAGGTAGAAGTAATAGAAAATGGACTGATGAAAGTAAAATAGGAGAAATACTTTTAGGGCAAGGATTCTTAGAAAATGTTATATATACTAAAAAACTTACTGGAATTACAAATATGGAAAAAGCTATAGGTAAAAAAGAGGTTACTAGACTTCTAGGAGATTATATTATAAAACCACAAGGTAAACCAACATTAGTACCTATAACAGATAAAAGACCAGTTTATAATTCTGCTGAAGCAGATTTTAAATAAATATTTTAAATAATAAGGAGAGATATGATTATGATAAAAGCAAAAAGAACAGGAACAAAGGTAACTACAGGAAAGGTAAGATTAAGTTATGCACATTTATTTGAGCCACATGCAATAGAGGGAAATGAACCTAAATATAGTGTAAGCGTAATAATTTCTAAAACAGATACAGAAACTTTAAAAGCTATCAAGGAAGCAACAGAACAGGCTAAAAAAGAAGGAGCATCTAAGTGGGGAGGAAAGATACCAGCAACACTAAAAACACCACTAAGAGATGGAGATGCAGAAAGACCAGATGATGAAGCCTATACTAATTGTTATTTTTTAAATGCTAGTAGTAAAAATAAGCCTGGAGTGGTAGACCAAAATGTACAACCCATACTAGATGCTACAGAAGTGTATAGTGGTTGTTATGCAAGACTAACTCTTAATTTCTATGCTTATAGTGCAAGTGGTAATAAAGGGATTGCTTGTGGACTAGGTAATGTTCAAAAGTTAGAAGATGGTGAGCCACTAGGTGGATTTACAAGAGCAGAAGATGATTTTGAAGCTATAGAAACAGCAGAAGATGATTTCTTAGGATAAAAAGTACAAGGTGAGTTTAATACTCACCTTTAATTATAAAAATAAAGTAGGTGATATTTATTGATACTTTAGCTATAGATGTTGAAACATACAGCAATATAGATATTAAGACTTATGGAGTTTATAAATATGTTGAATCTCCTGACTTTGAAATAATGTTATTTGCTTATGCTTTTAATGATGAACCAGTAGAAATAATAGATTTTATGAATGGAGAAAAATTACCTTGCAATGTGTTTTATGCTTTAACGGATCCTAACATCATAAAAACGGCATTTAATGCAAACTTTGAAAGAAATACTATAAAAAATCAATATCCAGCTTTATGTCCTCCAGAACAATGGGAGTGCACAATGGTAAAAGCTTTAACATTAGGATTACCAAGTTCTTTAGATATGGTTGGCAAGGCTTTGAATTTTGAAGAAGATAAGCAAAAAATGAAAGAAGGTAAAGCATTAATACAATATTTTTGTAAGCCTTGCAAGCCAACAAAAAGCAATGGTAAAAGAACCAGGAATCTTCCAGAACATGATATGGAGAAATGGGAACTATTTAAAGAATATTGTAAGCGAGACGTTGAAGTAGAAAGAGAAATAAGGAATTTATTAAACAGATATAAAACTACAGAAGAAGAAAAGAAATTATGGCAACTAGACCAAAGAATAAATGATAGAGGGATTAGTACTGATTTAATACTTATAAAACAAGCTATTGAGTGTGATGCGGATTATACTAAAAGATTAATTCATGCAGCTACTAAACTTACTGGTCTTGAAAATCCGAACAGTCCTACACAGATAAAAAAATGGATTGGTGAGAGAATTGGAAGAGAGGTAAAGACATTAACTAAAACAAGTATTCCAGAACTTATAAAAGAATCTGAAAGCCTTGGAAAAAGTGAAGTAATAAAAATGTTAGAACTAAGACAACTTATGGCTAAAACTTCTATTAAGAAATATGAAAGCATGAATAAGGCAAGATGCAAAGATGGTAGGGTAAGAGGATTACTTCAATTCTATGGTGCTAATAGAACAGGTAGATGGGCAGGAAGATTAGTCCAAGTACAAAACTTACCTCAAAACCATCTACCAGATTTAGATGATGCTAGGAATTTTATTAGAGAAGGTAAATTTGAAGAAGTAGAATTTTTATTTGATAGTGTTCCAGATACATTAAGTCAGCTTATAAGAACAGCTTTTATACCTAAAGAAGGCAACAGATTTATAGTATCAGATTTTAGTGCTATAGAAGCAAGAGTTATTGCATGGTTTGCTGGTGAACAATGGAGATTAGATGTTTTTAGTACACATGGAAAGATATATGAAGCATCAGCTAGTCAAATGTTTAAAGTACCTATAGAAGATATAAAGAAGGGTTCAGAGTTAAGACAAAAAGGAAAAATAGCAGAATTGGCACTTGGATATGGTGGAAGTGTTGGAGCTCTTAGTTCAATGGATAGGAAAAGGAGTATTCCAGAAGAAGAACTTCCAGGACTAGTTAAAAGTTGGAGAAATGCTAATCCTAATATTACGAAATTCTGGTGGGATTGCGATAAAGCCGCAAAGAAAGTTATAAAAGAAAGAACTACTGTATGTATGCAATATGGACTTAAGTTCATATATGATCCTGGAGTTTTATTTATACAATTACCTAGTGGGAGAAAACTAAGTTATATAAGACCTAAAATTGAACCACATGAAACTTTTAGTGGAGATAAAATTACCTATGAAGGTATGGAACAAACCTCTAAACAATGGAAGAGAATAGACACTTATGGGCCTAAGTTAGTAGAGAATATAGTACAAGCTACAGCTAGAGACTGTTTAAGAGAAGCTATGTTTAGAGTGGATAAAGAAGGATATAAAATTGTAATGCATGTACATGATGAAGTTGTATTAGATGTACCTAAAGATTTTGGAAGTGTAGAAGATGTTAATAAAATTATGGGGCAGCCTATAAAATGGGCTCCTGGGCTTCCACTAAAAGCTGATGGTTATGAATGTAATTATTATATGAAGGATTAAAGGAGGCAGCTATGGAGATTAAAACAAAAAATAATTTAGATATAAATATTAAATATGATGGTTCTATAGCCATAGCTACAGGAAAGAGTAGAAAGGAAACTCATTGGAAAAATAAAAATATTTTATGGTCAACTCTAGTTGATAAATTATCTAAAACTACAAGAACACCTGAAACTTATGCAGAATATAAAAAAATGTCTAAGAGTGAAAGAGACAGAATCAAGGATGTAGGTGGTTTTGTAGGTGGAGGACTTAAAAATGGTCGCAGAAAGGCAGAGAACGTCCAGAACAGAACATTATTAACTTTAGACTTAGATTATGTTAATGGTGATATATGGTCAAGCATAGAGTTATTATGGGATTTTTCAGTAGTTATGTATTCAACCCATACTCATATACCAGATAATCCAAGGTTAAGGCTAGTAATTCCTTTAAGTAGACCCGTACTCCCAGATGAATATCAAGCTATATCCAGAATGGTGGCTGATGATATAGGAATAGACCAATTTGATGATACAACCTATGAACCTAGTAGATTAATGTATTGGGCAAGCACTTCAAGTGATGGTGAATTTATTTTTAAAATCCAAGATGAGCCTTGGTTAAATCCTGATGAAATTTTAGATAGATACACATTTGGTTGGCAAGATGTAAGCTATTGGCCAGAAAGTTCAAGATCAAGGGCGAAATTAAATAGTGTTATTAAGAAGCAGGACGATCCATTAACCAAGAAAGGTATTATAGGTGCATTTTGTAGAACTTATAGTATAAGTGAAGCTATAGCAGAGTTTTTAAATGATGTATATACTCCAGGTATAGATGATACTAGATATACATATGCCGAAGGTAGTACAACAGGTGGTGTTGTAGTTTATGATGATAAATTTAGCTATAGCCATCATGGCACGGATCCAGCTAGTAATATTTTATGTAATGCCTTTGATTTAGTTAGAATCCATAAATTTGGACACCTAGATGATGAAGTAAGAATTGATACAAAACAAAACAACTTACCTTCTTTTAAGAAAATGACTGAAGTTGCAATCAATGATAATAAAGTAAAAATTCAACTAGGAAAGGACAGAATAGAAAGTGTTCAAAATGAATTTGAAGTAGTTAAAGACGATGATATTGAATGGCTAAAGTTACTAGAGAATGATAGAAGTGGTAGAATATGTGCAACAATAGATAATGCCAAAATAATATTGCAGAATGATATTAATTTAAAAAATAAGCTTGCATACAATGAGTTTAGTTTAAGAAAATCCGTAAAAGGAAGCTTACCATGGTATAAAAGTGACAAAATTAGGTTTTGGGAAGATGGAGACGATTCTGGATTAAGGCATTATTTAGAAAAGGTTTATGGGATTAAAAGAGCTGCACCTAATATTGAAGATGCCTGTAAATTAATTTTTAAAGAAAATAAATTTCATCCAGTTAGGGATTATTTAAATAGTTTAACTTGGGACGGGAAAAAGAGAGTGGAAACCGTCTTAATTGATTACTTTGGTGCAGAAGATAATATATACACTAGAGCCGCGGCAAGAATATTTATTTGTGGGGCGGTAGCAAGAATATTTAATCCGGGTTGTCAATTAGACTATGTAACAACAATAGTGGGCAAACAAGGTATTAGAAAAGGGACATTCTATAAAACAATGGCTAAATATGATGAATGGTATACAGAATTAGCTACTATAAAATATAAGGAAGCTATAGAGGAAACTATGGGTAAGTGGATTGTAGAAATGGCTGAAATGGCTCCTACTAAAAAAAGTGAAATAGAAGAAATGAAGGCTTTTATAACTAATAAGGGTAAAACCATAAGATTAGCATATGCCCATAATCCTACAGATATACCAAGACAATATGTATTAGTAGCTTCTACCAATGAACCATCTTTTTTAAAAGACCCAACTGGTGATAGGAGATATCTTCCGGTGGATGCGGATATGGATAAAGCAACTAAAAGTATAGTAAAGGATTTACGAAATGAAGTAGATCAAATATATGCAGAGGCTATGGTATTATATAAAAAATTGAAAAATAAAGCTTTAATGTTAAATTCAGAGGAAGAAGCATTAGCCTCAATAGAGCAGGATGGCCATAGAATAGTAGATGATGAAGAAAGTACTATAATAGAATTTCTTGAAACACCTTTACCGAGAGATTGGTATGAAAAAGATTTATATGAGAGGCAAAGATATTTTAATGATTCTTTATCTCCTAAAGTCACAAAAGAAGATGGAATAATAAGAGATAGAGTTTGTGTGAAAGAAATCTTGAATGAACTTTATGGTGTAACTGGAAAAGTAGATTTAAGAGATTCAGCTAGAATAAATAAAATTCTTCAAGGATTAAAAAGTTGGCAAAAACAAAAAACACCAATAAGAATTAGTGGATATGGGAATCAAAGAGGATATTATAGAAAATAGTTTTTACTACAAGTGTCTACAGAAATCTAAAAATCTGTAGACACTATAAGGTCAATAATACCAATGGGTACTATATATTTGTCTACAATGTCTACAGTATTTACTAAGGGAATATTATTAAAAGGAGATAATATTACAATATATGGGATATTATCTTACTTCCATAATACTCATAAAGAAAAAACTGTAGTAACTGTAGACAAAATATCTTAAGACATTGATATTACTAGTTTGTCAATGTCTACAAATATTAATTTAGAAAGGGTGTAATTTTATGAACTGCGATTATAAAAGAAAAATATTAAAAGAAACTTTAAAAATATTAGATAGTAGTTATTCAATACAAACTATAGATTGGTCTGAATGCTTATACAGGGATTTAGGAAATGGGATAGATTTTGAAATTGAATATGGCAAGGGTAAATTTGATATATACGTTTGGAAAAATAAAAGTAAAACAATTGAATGTATACTTGATATAAAAAAAGCTGATTTAAAGATAACATTAGAAGGATTGATTAAAAAGTATGGAAGAATCAAGAATTGAAAAAAGACTTAAAAAAGAAATAGAGAAGTTAGGCGGTAAAGCTTTAAAGTTTGTTAGTCCAGGAATGTCAGGAGTGCCAGATAGGATTATTTTATTACCACAAGGAAGAATTGTCTTTATAGAACTTAAAGCACCAGGGAAAAAACCAAGATCTATACAGAAATATAGAATTAAAGAATTAAAAAATTTAGGATTCAGAGTTGAAATTATAGATTCTATTGAAGGAATTAATAATTTTATAAGAGAGATTAAATAATAAAAATTACTCAAAAATGAGTAAAAAGAAAGAGGGTGATATTATGAACTTTACCCCATGGAATTATCAGCAATATGCAATTAATCACATTTTAGATCATAATGCATCAGGATTATTTTTAGACATGGGTATGGGTTGAGATTAAGGTAAAACAGTATCAACATTAACTTCAATAGATTATTTATTATTTTTAGGAGATGTAAGTAAAATTTTAGTTATAGCACCTTTAAGAGTAGCAGAAGATACATGGAGTACTGAAATAGATAAATGGGATCATCTAAAACATTTAACAATATCTAAAATTTTAGGAACTCCTAAACAAAGAGTAGAAGCCGTTGAAAAAAATGCAGATATTTATATTACAAATAGAGAGAATGTAGTTTGGTTAGTAGATAATTATTTTAAAAATTGGAAATGGGATACTTGTGTTATTGATGAATTAAGTTCTTTTAAATCTTCGAAGGCTAAAAGGTTTAGAGCTTTAAAGAAAGTTAGACCATACTTTAAAAGAATAGTAGGACTTACAGGAACTCCAGCACCTAACAGTTTAATAGATTTATGGCCACAACTTTATTTATTAGATGGTGGTAAAAGATTAGGTAGAACTATTACAAGTTATAGGCAACAGTATTTTTACCCAAAACAAATGAACGGACATGTAGTTTATAAGTATGGATTAAAAGATGGAGCAGAAGAACAGATTCATAAAAAGATAGGTGATATTTGTATTTCTATGATGGCAAAAGATTATTTAGATATTCCCAAAAGAATTGACAATGTTATAAATATTAATCTACCTAAAGGTTCTATAGATAAATATAAACAGTTGGAAAAGGAACTTGTAATAGAATTAGGAGAAGATGATATAACAGCAGCTAATGCAGCAGTACTTACTAATAAATTATTGCAAATATCTAACGGGGCTATATATTCTGAAGATAAGTCTGTAGTAGAAATTCATGATGAAAAACTAAAAGCTTTATTAGATATTATTGAATCAGCTAATGGTAAACCAGTTTTAATATTTTATAGCTTTAAACATGATTTTGATAGAATAGTTAACTTTTTAAACTGTAAAAAATTAAAAGCTGTGGGGCTTAGAAATTCAGATGATATTAGAAAGTGGAATAATGGAGAAATACCAATTTTATTAATACATCCAGCATCAGCGGGTCATGGCCTAAATCTTCAATATGGTGGTAATATAATTGTTTGGTTTGGGCTTACATGGAGTTTAGAGTTATATCAGCAGGCTAATGCAAGACTTCATAGACAAGGACAGAAACAATCCGTAGTAATACATCATCTTGTAGCTAAAGGAACTGTAGATGAAGATGTAATTAAAGCTTTAGATAACAAGGAAGTTAATCAAAATACATTGCTTGAAGCAGTAAAAGCAAGACTAAGGAGGGGGATTACAGATGACAACGAAAGAAACTTTAGAGGAAATTGTAAAACGAGTTATTAAAGAATATGATAAGCAACAAAGAGAAAAGGCTAAGAAGAAAAGAGATAGAAGACTTAGAAATACTGATTTACTACTTAGAAATTATGATAATTTAATTAAGCATATTGATTATGCCATTGAAGATGAAAAAGAACTTAAAGCAGAGGATCCGGAGGAGTTATTAGATGAAATTGAGGAAGAGATAAATCTAGAAAATGATGAAGATTATGAAGGGATATATATAAATGCTATAAAGAGAACTAAAACTAGAACAAGAATTATATTGAAGCATATCGAAGTAGCTATAGAGTTTTACAGGCAAAAAACAAAACTTTCAAACAGTACTAATGAGACAAGAAGATATACAGTTATTTATAAATTTTATTTCGAAAAAAAGAAAATCCCACAAATAGCTGAAGAATTAGGATATTCAAATAAAACTATTAGCCGAGATAAAAAAAGAGCCATTGAAGAATTAAGTGTCTTATTTTTTGGGATAGATGGAATAAAGTTCAGCCTTTAAAAGTTGTCCTTTTTATGTCCTTGACTGTACCTTATAGAAGATATATAATGGTAATGTGAATAATTATAAATAAATAATTTGTAAAGCACTTAGATTAATTTCTAGGTGCTTTTTCTATTTAAAGACAATAAGAATAAAGTAAAAAGACTGTATGAAGGTTGTAATAGGCACTATTGTAAATATAGGAAGTACTGACGGTTTAGGACACATATTCATAAATCTATACAAAAATATAAAAAGTTTAAATTATCAAGAGGATTTAACTATTTAACATAGAAGTTTAGTATATAGTGGAGGAGTAGATGTTGGTGTGTATATCAGCAATGGAGATTACTATTTAATACCACTACAGTAATATCTGGAACACAATCAACTACACTTAAATTCTAAAATTAATCAAAGAAAGGATAATCTATATGCGGTTATTTATACTATCCATTATTAGTGCTTTTATTGGTCTTTTAATTGGAGGTTTTATATTACCACCTATTATTCCAGGATTAAGTGAGGCTTATTATATAGTTTACATATGTGCATTTAGTGGTTTCTTTATTCCTAGTTTTTATGTATTAGAAAAACTATATAAAAGTCATAAAAAAGGAAACGATAATTCGTAGTTATTTAATGATTTGCAATATGTAAATTTTTTATAACTTCATAAAATAATAAATATATAATGGGAAAATATAAGTGAATAACTTAGGAAAGAAGATATTAGGCACTCAATAATGGGTGTCTTTTTCTATCCCCAAAACAAACAATAGCAATTAACAATGAGGAGGTGAGTCTATGGCTAAATCTAAATATGAAACTAATGTAAAAGATAAGCTTATATTAGTTGAAGGGTGGGCAAGAAATGGGCTCACTGATGAACAAATAGCAAAGGATATATCTATTAAATTGAATGTTTTTTATATAACAACAATTGTAATTATGGTAGAAGGAATTAAGTAAGTTATATAGAATGATTTTATTAGGTGATATAAATGATACTAAAAGAAAACTTATCATATCCATTAGTACATTATACAGATATGTATGGCAATTTCATAGGATTTCAGAAAGATAAAAATTCAGAGGTAGTTTTATGTTCATGTATGAGAAAAGCAGTAGAAAACTGTATAAAACTATTTTTAAAATATCCTTCAAGTTTGCTTAATCCTCCAGAGTGGATATTGTTAAAACAACTGGATATGCCAGAAAGTATAAATGATGTTATAAGAAAGAAAAATCCACCAGTAGGGCTAGAATGGCTAAATTATATTAAGTTTAAAGAAGAGGTATGCCATAGATGTAATATAGAAAAACCTACTAAAGAATATTGTACTCCTATGTATGGAACTAAATTTAAAAGAACCTTTGGATGGTATATAAATATAAATTACTTTAATAAGGGAATAAATCCTAGTACACATGATGGAATATATTATTTAAAAGAAGATGGTCCTATTGAAATTAAATTAATATTAGATCCAACAGATAAAGATTTACTTGAAGATATAAGAAGGTATAAACTACTAGATACATTTGAAGATAAAGAAATATTGGATATGCTTAAAAAGATAAAACATAGAGAAGAAGCAATAGTATTAAGATATTTTCACATAGAAGATAAAGAGTTACAATATCAAAAATTATATTATGCAATTGAGTATGTAATGAAACAAAGGTTAAAGGAAGTACATAAAGTAATTGAAAATGAAGTAAGAGACTGGTTTAAATCTAAAAGAGTTGGTGAGAAATGGGAGAATGAAACTAACTTATATAAGATAATAAGAAAACTATATCCAGAGTTAACTATGTATAGACATTTTAGGCCACCATTTTTAGATGGACTAGAATTAGATATTTATATAGAAACTTTAGATATAGGGATAGAATATCAAGGAGAACAACACTTCAAACCCTTTGAACATTGGGGAGGAGAAGAAGCTTTTGAGAAAAGACAAGAATTAGATAAAAAGAAAAAGGAATTATGCGAAAAGAATACTATTAAATTAATTTATTTTAATTACAATGAAGAAATAAATGAGGAACATATAAGAAAAAAGTTATTAAAAGAGCTTAATATATAGGCTCTTTTTTATTTATAGAATAAATGTTCTTAAAAAGTATAGAAGGAAAGGAGGTACAGTATTCTAATGAATATAAAAGAAACATTGCTTAATCTAAATGAAAGAGAAAAAAAGGAAAGAAAAAAAGCACTAAAAGATTTTATATTTTATTTAGGTGAATGTGAAAATATAGATGCTGCGAAATTAAACCAGGATCTATTAGGACAAAATTGGATTACTTTAGACGATTTAGATTACATACCTTCACAAGTAATAGATAATAAGATTAAGCCTTTAATAAATAAGCAAGCTAGATTTATGTTTGGTAAAGAACCAGATATACTATTAAAGCCATTAGATAAACAGAATAAAGAAACATGTGAAAAATTAAGACAATATATAGATGCTATCTTAAATGCTTCTAAATTTTGGAGTAATACCATGAAAGCTTTTAGGCTTGCAACAGTAACCAAAAGAGTAATGTTAAGATTAGAAGCTAATCCAGGGCAACCTATAAGACTTTATTACCATGATATAAATGACTTTAGTTATGAAGTAGATCCTAATGATATAACTAAATTGAATAAAGTAATACTAGTAAGACAAGATGCTGAAACCGCAAATAAAGAGGAAAAAGACCAGATATGGTGCAGATACACTTACTATATGAATAAAATAAGTGACAAGGAATCTACTTGTTATTTAAGAATAGAAACTTTTAAAGGTAATAATCTGGAAGCACCAATAGAAATAAAAGAACAGGACACAGGACTATCTAAAATACCATGTTGGGTAATTTGCAATGAACGAAGCATTATTAACCCTTATGGGCAAAGTGATATAAAAGATTTAAAACCATTGCAAGATAGCTACAATAGGAGACTATCAGATTTTAACGACAGTTTAAGATTTCTTATGTTTGGACAAACAGCTGTAATAGATGCAACAGAAGATACGGTTAATGCTTGTAACATTGCACCTAATTCACTTATGGCTTTAAAAAGTATTGATGATACAGAAGGTAATAAACAAGCTAAAGTACAGCGTTTAGAGAGTAATTTTACTAATGCAGATCCAGTACTTAAATATTTAAAAACATTAGAAGATAGTATGTATGAAAAATTAGGAATACCTAAGCCAGAAAGTCTTCAACAAGTTCCAAGTGCTAAGAGTATTAAATATATGTACATAGAGCTTGTAGCACGTTGTGAGGAAAAATGGCATGATTGGGAACCAATTATAAGGCAAATGATTAGATTAATAGTTGAAGCTTGTGGCAAATTTAAATGCTATGAAGAGTGGAAAGACGAATGGAATGACTTACTTTATAATATAGTTTTAAATAAAAATTACCCTATTCCAGAAGATGAAGAAGATAAGAAAAGACTTGCAATGGAAGAGGTAAGAACTAATGTAAGAAGTCATAGAAGTTACATAAAGGACTTTACAGATGATGAAAATGTAGATGATATTTTAAAAGAAATATGCGAGGATATAACTTCTATTACAGCAGCAGAGCAAGAACAATTTTTAAGGGAAATATAGTACTAATCTTCCCCTCATATATGGTATAATTTACATGAAGATAAGGAGGAGGAGTTATGGAGTTGGTAATTATATTTTATATACTATTTATAATATTTTTTTCCGCATTAATTATATCAGCTTTAACAGGAAGTAAAATACTTAAAAATAAAAAAGATGCAATTGGTGTATATTCAATAGGAACTGTAATTTATGGAGTTTTATTCTTCCTAACTTTAAGATTGGAGCTTAGCAGTTATAATTATATATACATGGAGCCAGTGAGTAAAACATCTATTAATAGAAAAGTTAGTAGTAAAGTTGATGGAAATAACAAAGGTAATTCACAAGAAGCTAACCAAGAAAAACAAATAAAAACACAAAATAATCATAAAGGTAAAATAAAAGGAAATATTAATAAAAATACAGGAGAAAAAATATACCATGTACCAGGCAGTACTTATTATGATAGGACTATAGCAGAAGAATGGTTTAGTACCATAGAAGAAGCTGAGAAAGCTGGATACAGAGCACCTAAAAGATAATAGGTGCTATTTTTATGCTTAAATAAAGTGAGGTGGTGAGATGAATGAATACTTAGAATTAGTAGATAAAGCACAGAAACAAAGAATAATGCTTACTAAGAAGCAAATAAAAAATATAAAGGATTTATACAGAGATGTAGCAAAAGATTTAAGGAAAAGAGCTAAAAGAGCGAATAAGGATAGTTTAAGTGAAAGATGGTTATTGGACTATCAAAAACAATTCAAGAAAGACATAAAAGAATTAAATAAGATTCTTAAAAAAGATATAGAGTATTCTATATTAGAAAGTGCAAAGTATGCAACAAATATTCAAACTGACTTTTTTAATTTAATGGATGTAAAATATAAATTAAATTCAAAAGAAACATTTTCTAATATGTTTTCTAGGATACCGCAGCAGGCATTAGAAGAACTTATAAATGGAGATTTTTATAAAGATGGTAAAGGGCTTTCAGAAAGGCTATGGTTCCATGAGAAAGAAGCTAATGCAAACTTTGATTATATAATACAAAAAGGATTATTAGAAAAGAAGAGTACTTATGAGTTAGCAAAAGATTTATCGGATTATGTTAATCCAGAAGTTAAAAAAGATTGGGATTTCAAAAGGATATATCCAGGAGTAGGAAATAAAAAGATAGAATATAACAGTTTTAGGTTAGCAGTAACTTCTATGAGTCATGCTTATCAATTATCTATGCAGAGAAGTTGTAAAGCTAATCCATTTGTAGAAGGAATAGAGTGGCATACAAGTAATTCTCATAGAGGACCATGTTCCATATGCAGAGAAAGAGAAGGAAAAACATATAAACCAGATGAATTACCTTTAGATCATCCAAATGGAGTATGTTATTTTACACCTGTTATAACTAAATCTTTAGATGAAGTGGGCATGGAACTACATGGTTGGTTATATGGGGGAAGTAATAATAAATTAGATGATTGGTACAAAGAATATGGAAGAGAATTTGCAGGAGAAAATAATTTGTTTAGAAATATTAGTAAAAAAGGTAACAATAATGATAGCAATAGTGATATAATAAGTAGTATAAGAAATGACATAAAAAGTGGAAAATATCCACTTGAAATATTAGAAGGTAAGCAAGGAAAGCATATTAAAGAACATAATAATTATATTGAAGGTAGAAGTTACTTAACAATATCAATTGATGAAGCACAAAAAATAGTTAATAAATATGCAGGAAGTGGAATTATAAGACTAAATCAAAACAATGAATGGGATAATAAAGAGATTGTAACTATAGATAAAGAAATAGGTATAAATGTTAATAATATGACTAATGAAGAATCAAAAACAAATAGATGTAAAATACATTATTCTAAAAAAGGTACTCATATAGTACCAACTAAAAAGGAGTGATTATATGAATTTGTGGGAATATGTTGGTAAAACAATAAAAATAACCTGTTTAAGTGGTAATACATTTCAGGGTAAATGTAGTGACTATACTCAAGCTATAGATAATGAACCTGAGATAGCTAGCATTGGAGTAGATACTGAAAGTGCAAGTTATGAATTGTACGAAAATGAAATAAAAAATATAGAAATAATTAATTAAAAAGCACTTACTAAGTAAAAATAGTAGGTGCTTTTATTATGTCTGAAAGCGAGGTGAACATTATGCATCATTATATTACAAAGTATAAGGAAAATGGAAAAAGATATGCAGAGGCTTGGATACAAGTAAATATATTCAGTTTATGTCTCTGCATATGGAAAAAAAGAATAGAAATTTAACTATTTAAATTTTTCCCACTTACGACCTTTTTCTTGAGTAGGAGGAAGTCTATCACCTGGATCAATTTTTACTACTCTTGCTTTTGGAACATTACCACCACGAGGACCAACTTCTTTATATTTTCCTGCAGGCTGGTTATCTGTTCCAGGTTTGATTAAATTACTCATAAAATCACCTCCTTTCAACAAAATATTACCATATTTAAGAAAGGTGTACAAACTATTAAGTCTTAGAAATAAGGCTTTTTTATTTTGCCCTTAGCAAGGCGTAAAAGGCTAAGAAAGGAATGATAATATGCCAAAATTAAGTGAAATATTAGGAGAACACTTTAAACAGATACCAGAGGATTTACAAAAGAAATACAAGGATATAGACTTAGTGGACAGTTCTAACTATGTAGAAAAAAAGGAACTGGAAACTGCTAATAGCTCTATCAAGGAATATAAAAAACAGTTAAAGGATAGAGATAATCAGATAAATGAACTTAAAGAGGAGTACAAGGATGTAGATGGTTTAAAAGACAAATTAACTAAGCTTGAAGAAGAAAACAAAAATCAAAAAGAAGAACATGAAAAACAGTTAGCTAAGATTGAATTTCAAAATGCTCTAAATAAAGCATTAGATAATTACAATGTTAAGGATAAAGAGGTTGTAACTAAGTTATTAGATGAAGATAAGTTGAAACAAGATGGCAAAGACATCATTGGTTTAAAGGAACAAATGGAAATAATGCAAAAAGAGCGTAGTTACTTATTTGAAGAAGAGCAACCAGGAGGTACTGGAAGCATAGGAGGTGGTCCATCTTCATTTAGCAATAATACTGACCAACCTAAAAGTATAGGTGAAGTTTTAGGAAAACAACAAGCTGACCAAGTTAAAATAAATGAGACTATAGACAGTTTCTTTAAATAATGGAGGAATGAAAAGTGAGACAAAGTACAACTAAAATATTAGGAACTCAAAGGAACATTTTAGCATTAGCTGGAGCATTATTTCAAAACACTAACATTAAGGTAAGTAAGACAGTAGCAACATTAAAAGAAGGAATACTTGAAGCTGGAACAATAGTAGACAAAACAGGTAAAAAAGTAACTGATGGTACTGCTTTTGGAATTGTTTATGAGGATGTAGATTTTAATAATTCCAGTGGTACAGAAGTAGTTCCAGTGACCATTTTTGGTTTTATAAAAGAAAATGCATTACCACAAAAACCAGCTACAGAAGTAAAAGCAGCATTAAAAATGATTCAATTTTTATAATTAGGGGAGGAAATAAATATGAATTTACAAGATTTTATAAACGCAAATGAAATAGCATTATATATTAAAAATTTACCACTACAAGTTACACTAGATAAGGCTTTATTTCCAAATGATAAACAACTAGGAATGGAACTAGAAGTTGCTAAGGGTGCAAAACAAAGACCAGTAGCTTTAAGAATGAGCACATTTGATGTAGCAGTTAAACCAAGAACTTTAAAAGCTGACATAAACATTGAAAAGAAAGAAATGCCTTTCTTCAAAGAATCAGTTTTAATAAAAGAAAAGGATAGACAACAAATGCTTTTAGCAATGAAAGCTAATAACCAAGAACTAGTCAATCAAATATTAAATCAAATATTCGGTAATTATAAAGCTTTAGTTGATGGTGCAGAAGTGCAAGCAACTAGGATGAGAGCTCAACTACTTCAAAGTGGAGAAATAAAGATAATTACTGATGATGGTGATGTAGTTGTAGATTATGGAATTCCATCTGACCATAAAGAAGTGCTTGCTGGCACTGCTAAATGGAGTGATAAAACAGCTAATATAGTAGGAGACATTGAAAGATGGCAAAATACTTTAGTGGCAGAAGGTTATGCAAAACCTAATAGAATGTTAATGACACAAAAAACTTTCGGATATATAAGAGCAAATGCTGCTATAGAAAGTGAAATTAAAGGCATAAGCAATGTGGTAGTTACTGATAAGCTAGTAAAGAATTACTTAAAAGAAAAATTAGAAATAGAAGTGGGTATATTAAATGGTGTATTTACAGCCGAAGATGGTAGCACAATGAACCTTTACGAGGATAATAAAGTTACTTTAATTCCTCAAGGTGCACTAGGCAAAACAATGTATGGTACTACACCAGAAGAGGCTGACAAAATGTTTGGTTCATCTAAATTAGATACTCAAATAGTTAATACTGGTGTAGCAATAACTACTATGGCAAAAGAGGATCCTGTTACAGTAGAAACTAAGGTATCACAGTTAGTTCTACCTTCATTTGAAAGGGCAGATGAATGTTTTTTTGCTACAGTAGCTGAATAAGAGGGAAGGTGAAATACCTTCTCTTTTTAAATTAAAAATAGAAAGGGTGGGTAATATGGCTAAGAAAGCAGATGAAAAATTGAAGAAAGTAAAAGCTTTAGTAAATATAAAATATGATGAAAGCTGTTTTAAAATAGGTTATGAATTTGAGGTTAGATCAGAGGATAGTGAGGAAATGACCAAGAGAGGTTATGTTGAGTCTTTAGAGAAAATAGAAAAAGGAGAAACTAAGGAAGGAGAATAAGCATGACTATACCTTTGGAAATATTAAAATTTAATCTTCAGGAGCGAGAATATCCATATTTTGAAGATAATGACCTGAGTTTGTTATTGCAATCCAATGATAATAATATTAATAAGGCTAGTTATAAAGGTTGTTTATTAAAAGCTAACGCAGATGATAAGTTAGAGGTAGCAGGTGTAAAGTTAAGTTCTAATAGGCAATATTGGTTAGGATTAGCAGAGGAATATAAAAAAGCATATGAAGAAAGTTTGCAAGGGAATATAACAGGATATAAAACATCCATGAAAAGAGTTGATGGCCAATGAGTAAATTTAATAGAGGAAAAATAAGCAGACAGATATATAAGCAATTAGAGAAAAAAGGATTATTAAAAGAAATTAAGATATTAAGAAATGGTAAAAATGCTTATGGAGAGAAATTAGAAGATTTATATGTAGCAACTATTAAGGGTTATTACTACAGAAAAGAAAACAAGATAAATATTAGTTCAGATACAGGTGCTACTATAAATACTAATTACTATGATAAGTTATTAGTTACCTACAATGAAGAAAGTAAAAAAATAAAGCAAGACGATTATTTAACATTAGATGGCATTAAATACAAAGTAATTGATACAGGGAATGTAGAAAACATAGTCTTTGATATGTATTTGAATAGGATGTAACATTATGAGTTTTAAATTTGATATAGAAAGTGTTATTAATGGATTATCTGAATTCGAAGTAAAGAGTAAAGTATCCATAGGAGTTTATGCTGATACTGCAGGAAAGAAATTAGAAAATCATGCTAAGAAAAATGCACCTTGGATAGATAGAACAGGGTTAGCACGTAAAACTATAGAGGGTGGTAAGCAATGGGAAGATGATAAATGTATTGTTTATGTAGCTGGTAATATGGAATATTCACCATTTTTAGAATTATGTAATGATAAGCAATATGCCACTTTAAAACCAGCAGTAGATAAATTAAGCCCTGAAATACTAAGAGGCATGAATAATTTGTTAGGAAAGTGATTAAATGAGTAGTTTTAATTATAAAGTTCCGGGGGACCACCTACAACAGGATTTAATAAATAATACAATTCCCCAAACTGTATGGCAAAAGATATATTTACACTTAAAAAAACTAGGATATGAAGTATATTCCCCTGGACAAAAGAGAGATAAATGTATAGATAGTTATGTAGTTATAAAAGAGAATGGGACTTATGCTACAAATGGGAATGTAACCGGATATAAGTTATTTGACATCATTATTTATCATCCTATGTCTAATTATACTTCTATGGAGTTTTATGTAGAGAATATAAAACAAGCTATGAAGGATATAGGAGAATTAAGACCTACAGGCAATGAAACACCATCAATTATTGATGAAAAAATAGAAGCTTATACTGCTAGCATAGAGTACCAACAATTCAAGAGTTTAAGGAGGTAATAATATGGATGGTAAAACATTAGTTAATGTAATTAAGGTAAATTTTATTGATGAGGTTACAAATATAAAACATACAATTGAAACTTCTGATGAAATAGATATAGAGCCTATTAAATCTGACGGTAAAAGAGATATATTAAGGGTTAAAAATACTATTTATGGCATTAATGAAACAGAAGATATTGTAATTGGTTATAAATTAAAACTTAAAGACAACTTATTTAATATGAAAACTATGTCCCTTATTCATGGTGGTAGTATAGAAGGTAATAAGTATTGTGGTGCAGAAGCAGGAAAGGTAGCAGAAAGACATCCATTTACAATGGAAATATTTACAGAAGAAAAGGATTATAGTAGAACTACAGGTTATGCTAAATTTACTTACAAGCATTGTAAAGGTAAACCTGCTAAATATAAAGTTAAAGATGGTGAATTCTTAGTTCCAGAATATGAAGCAGAATCAATTCCATTTAGAGGAGAGAAACCAGTTGAAATAGAATTCTTGGATACTTTACCTAGCAAACCAGAAAAACCAGATCCACCAGTTGAAGATATAGGAGTTGAAGGTGGAACTGTAAAAGATACAAATACAGATGTTGGAGTAGAAATAACTAATAGGATAGTATGGACATTTAAAGAACAAATAAACCAAGATGATGTAACTAAGACTAATTTTAGCATAAGAAGAAAATCAGATAATAGCTTGGTTCAAGGTAATGTAACTATAGATGGAACTAAGAAAATAGTAACATTTGTACCTACTTCTTTAGCAGTAGATACAGTATATATTGCAGAGGCTAAAGAAGTTAAAAAACTAGATGGAAGTGGAACTACTACATCACTAGATACAGAATTTAAAACAGTAAAAATAGCATAATAGGGGGAGAAATACTATGGAGATAACAAATTTAGAACAATTAAAACAGATGGCAGAATGTGATGTAATAGAATTACCAAGATTTAAACAGGAGATACCTTTTGTAGTTAAAGTTAAGAGGGTATCTATTTTAAATTTAGTTAGAAAAGGTATTATACCTAACAGATTATTAAGTGCAGCAGAAGAATTATTTTATGGTAAAACAAGCAATAAAGGCAATGTAGATATGAAAACACTTACAGATGTAATGTTCATTATGGCAGAAAAGGCACTTGTAGAACCTTCTATTAAGGATTTAGAAGAAGTTGGACTTGAATTAACAGATGAACAAATAGTTGCTTTGTTTAATTATACACAACAGGGGGTACAGGAGTTAGAATCCTTTCGTGAAGAGCCAGAGGATAATGACGGTGCTAACGATAAGTAAACAGTACAAACAAAGACCAAGTGAAATAATAGGACTTACAAATGATTATGAAGCATTTTGCTTCGATGAAGCTTGTATTTATATAATATCTAAATTACAAGAGGAAGGTAGTCCTAAACCTAAATTTATAGATGATGAAGATAGAAATAAAACTAATAATAATGATGTAATAGAGTGGTTAAATGCTAACAATAAATAGTATTTAACCATTTTTTATTATTCCCAAATTGGGAGGTAAGAAAATGGCAATAAACGTAGGTACTGCAATTGCATACTTAACTTTGGATAAAAGTCCATTCAATAATGGGCTAAAGAGTGCAGGGGCGGAGCTTAAAAACTTTATAAGAGGTACAGGAGAAGCAGGTGGAAGGATAAAATCTTTAGGAGGAGCATTAACAAGTGTTGGTGGAACCCTAACTAAAACAGTAACTTTACCTATTGTTGGTATTGGAACAGCTTGTACTAAAATGGCATCTGATTTTGAAACAAGTATGGCAAAAATAGATACTATAGCAGGTGCAAGTAAAAAAGAGTTAGCAGATATGAGAAAAGAGATTTTAAAAGCTTCAAGTGAATATGGTATGGCAGCTAAAGATTTTGCCCAAGCGACCTATGATTCTATTAGTAGTGGTATAGATAAAGCTGACGCAGTAGCATTTACTAAAGATAGTGCTAAATTAGCAAAAGCTGGTTTTACAGATGTTGCAACAGCTACAGATACTTTAACTTCTGTAATAAATGCATATGGTAAAAGTTCTAAAGACGCAACAGATATAAGTAATCAGATGATAATAGCACAAAAATTAGGTAAGGTTACAGTTGATGAAATGGGTGCTAGCTTAGGTAATGTTATTCCTATTGCAAGTGCTTTAGGAGTTAAAACGGAGGAATTATTCTCTAGTATAGCAGTTGCCACTGCACAGGGTATTAAACCTGCACAATCAATAACAGGACTTAAGGCGGCAATGTCTAATATAGTAAAACCATCAAAGGAAGCTAAGAAGGCGGCGAAAACATTAGGATTACAGTTTGATGCAAATGCAGTTAAAACTAAAGGTTGGATGGGATTTCTACAAGATGTAAAATCCAAACTAGAAGAATCTGCACCTACATATGCGAAAAAGTTAGATGAAGTTAATAAGCTAAAAAAAGCAATAGAAAGTTCTGGTGGAAGTAGTAAAAAGTATAAAGAAGAAATTGAAAAAGAAAGAGAAAAGATAAAAGTATTAAGAGAAGAAAAGAAAAACTTAACCAGTAAGGACAAAGATCGTAAAAAGGCTATAGATAATGAAATAAAGTCTATGCAAGAGCATATAAAAACTATGCAAAAACAATCTAAAGCAGAAAAAGATGGGGCTAGTAATGTCAAAGAAATGAAAAAGGCACTTAAAGAAAAAGAGAAAGAACTTAAAATATTAGAAGGTACTAGTAAAGATACTCTATCGGCTTTTAGTACAATGTTTGGATCTGTAGAAGGATTAAATACTGTAATGTCTATGACTTCCAATTCTGGAGTTAAACTATATGACAAAAGTATGAAAGAAATGAAGGAAGATACCAATGCTACACAAGAAGCTTTTGACAAAATGATGGATACACCAGAAGAGAAGTTTAAAAAGGCTAGAGAACAATTGCATAATTTAGGTATAACCATAGGTGGTTATTTGTTACCACATGTATCTAGATTCTTAGACGCATTTAGCAAATTATTAGAATTAATAGATAAGCTACCAGAACCAGTTAAACATTCTATAGTAAGCTTTGCAGGTATGGCAGCACTTTCAGGGCCATTAATGATGTTAGGCGGAAATGTAATAAAAATGGGTGGAAATATAGTAAAAGGGGTATCTAAAATAATAACAGGTGTAGCAGGTGGAGTTAAAAGAGGAGTAGGTGGAATAGTGAAAGCATTTAAATTAATACCAAAGGCGGCGGGAGTATTTAAAACATTACCAGCTTTAATAACACCACATACATTTATTATTGCTGGGGCAATACTTGCAATAGGATTCATAGTATACGAGGTTATAAAGCATTGGGATAAGCTAGTTGCAGCAGGAAAGAAAATGGGGGGGATTTTAGAGAAAATATTTAAAGGTATAGGAGATACAATTAAATGGGTAATAGGTGGATGGAAATTATTAATAGGACATTTCATTAATTGGGGAAAAGAGAAACTTAAGAATATTAAAGATGGATTTATTAATGGAATTAATAAAGTCAAAGGACTATTTAAAGGCAAAGGCAAAGAACTTGGTAAAGGTGTAAAAGAAGGCTTTGAAAGTGAACTGGAAATACATTCTCCTTCACGTGTGTTTGTTGGATATGGTGGCTACATAGGCGAAGGACTTGTAGAAGGTATAGATAAGCAAGAAGGCTCTATTAATACTAAATTTAAAGGATTAGCGAATAAAATTAAAGATTTAGGCAATGTTAGACCAGAATTTGATGGACTAAATAATTTAGCTTTAAGTGGAGCTGGTAGTGGATATAGCAATATTGGAAATAGTAAACAATTAAACTTCAACCCTACTATAAATATGAATGTAACTGTAGCAGATACAGGTGGCAAAGGTACAGAACAGTTAACACAAGAAGTAAATAGCATGGGACAAGTAGCACTAAAAAATGGTTTAGTAGATTTATTTATGAAAGATGCAGTAAGAAACTAGGGGGTGTTATAGTTGGATTTTAATTTACAACTTAAATATGATAATGGAACAGATACAGGGGCAGTAATAACTAACTATAAGCCTCCTGTTCCTGTAACATTAAGAAAAGGTAATAAGAGTTTAACAGGATATACAGTATTTCAAGATGCAGTAAAAAGTGATACATTGATTAAATTTAGTGTAGCTTTTGAAACACATACACCAGAGGAAATTAGCAAGTTTAAAGAGTTTAGGAGTAAATATAATGAAAGGTTTATCTTTATTGATGAATTTGGCACAGAATACAGAGGATATTTCCAAGGAAACTTTGATTTAGATACTCCAATCGAAGGTGATATTTACTATATGAGTTGTGAGTTATTATGTCCTTGTCCTATAACTGGATGGGAAGGTGATTCTAATGAGTTATAAACTAGAAGTAATAAAAAAAACCAATGGTGAAAAATATACTTTTAAAAGATTATTTCTTAGTGCAGATGTAGATAGAAGAATAGATATGGGAGCTACGCAAGCTACATTTAAAATAAGTAATAACGCACCTATGAAATTAACTAATTTTGGTGGGATAGATGGAATAATAGACAATTCTAATAGAGTGAATTTTTATTGGAATGATGAACCTCAATTTACTGGAACAATTAAAAATTATAATATAAAATCTAGTGAGGAAATTATAGAAGTAATTGCTAGAGATGATTATAGTAAATTACTTAAACCGATAGATCCGGGTGTGCCTTATTTAATTTATAAGGATATAATGGCATCCGATATGGTATTAGACCTTTGCAAAAGAGCAGGTCTTAAAGTGCAAATAAAGAAAGATGAAATACAAGATTATAAAATAGAAAAAGAAATGAAAATTAAATACGATACACAATTTTCTGATGTAGTAGAAGAAGCAATAACTACAATGGAATCTAAAGGTATAATGAATAAAGAAGGTATTTTAGTAATTGGGAAACCATATCCTAATTATTTAGCTTCAGATGTTCCTAATAATATAAATTACAATTGGTATTATGAAGATTTTATAAAAATAGCTGATGCTGATAGTAAAAGAAATACAGATACAATGTATTCAAGACTTTTGGTTAAATACAACGAAAAAATTTATAATGTGTATGAAGAACCAAAAATGAAAAAATATTTAGGTGGAGAAAATAGATTTACAGAAGTTGAAACTGTACTCGCAGATACAGAAATAAAAAGACGTAGAATAGCAAATAAGCAATTTTTAGATATGTGGAGAAGAAATACAAATTTAGACATAATAGCAACAAAGGCTAATCCTAAATTGAAATTAAGAGATGTAGTAAGGACAAAAATTAAAGATGATTATTTAGGACACTATATGGTTGTAGGAATACATACTAGCTTTACACCAGACAGTGTAAATGATCAAATAGCATTAGAAGGTATGAGAGAAAATACAAGTTTAGCAGTATTAAGTACTGGTAATTATACCATAGAAGGAAAAAAGAAAGGCAGTAATAAAAATGAAACTTATGAAGATGTAAAAGAAAATGTATTAGAATCATTTAATATAGATAAAACTGGGAAAATAAAATTAGGTTTTGCAGATATAGAAAAACAGCCTTACTTAGAAGTAAAGGCTTTTTTAAATTCTCTTTTAGAAACTAAACATTATGATTTAGTTATACAAGATCCTAATAAATCTTTTTATGGCTATAAGCAACAGATATTAGGGGATTCAGAAAATATTATAACTAAAACTGGACTAAATAGTTGTCAAAGTATTACTTATAGTGGTTGGAGTGGGCAACCAGAATATTTTAAAATAACAAAGCCTATGCCTGGAAGATGGTATGTATATCTTCAATCAGACACAAGCGAAGAATATAAAGCGAATATAAGTGTTAATATGCCTTGGAAGAAGGTGAAAATAGATGAAGTTTAATGATTTTAGAGTGCCTGTAGAATATATAATTGACCAATATTGGAGAAAAAAACAACTTAAAGATAATGTATTCTTTGATGAAGAAGAAATAACTGATTTACCACAATATCCAGTAGATATTGAAAGGAATCCAGATACTAAAAAAGTAGAGAAAATAATATATGACAAAGGTGGAACTTTAGAATGGATAGAGGAACTTTTAAGGGATTGGCATAATAAAGTTACTAGAATAAAAGTTACTTTACCAGACCAAGAAGTTAAATACATAGACTTAGTAAGAGATGCTACAGGTAAAGTAACTAGAGTAGAGGTGAATTAATATGGGGCTACCTAGTTATGTTATAAATTTTGATGAATTAAGTGATTTAATTAAAGATTATTTAGAAAATGGAATAAATGTAGATATAGGAAATATAACACTTAATACAGAAGATATAGAAAGATTGTTAAGTGAAATTAAAGATAAAATACAAGGCGTAGACTACAATAACTTAATTCAAGCCTTAAATGATTTAGGTGCAAAATTAGATGGATTAAGTGGTAATTTAGGAATATTAGGAACACAAAAGATATATGGAAAAATGTTAGAAGTACCAGCAATAGTAGGACAGCATACAATAGAATTTACTGCACCAGCTAACAGTAAGTTAACGGGTATAACTTATTCTCAATCTAGTTGGAGGTTTGAAGATAGTTGGGATTTAGTTGTAGAAGAAGAAAGACTATTCACAGAAACAAGAACTAAAGAATATGGTGAGCATAAGTATTTTAATGTATTTTATCCTGTAGATGGTACTATAAAATTTATTTATAACAATAATAGTGGAGCTTCTAAAGTAGTATGGGTAGACTTTTGTATTCTTGAAGGTGGTTCAGAATGAGTTTACCAAAATATGTTGTCAACTTTGAAGAATTGACAGATGATTTAAAAAAGAAAATATTAGAATTAATTGATGATGAATTAAGAGGTAAATATGCAAAATTAAATGCTGATGATATAGAAGCACTATTAGAGGATTTAAAAGAATTATTGCCAAGTTTACAGTATAATATGCTAAAGAAAAGAATAGAGGGTTTTATTTATTATAACCATAATGGTATGCAGAAAAATGAAGGCAGATTATTAGATATTCCACCAATAATAATGGAAAATAAAGAGGATTTTATATTTGATAAAAATGTGTTTCTAACTGGATTACATTTTAATCAAACAGGCTGGAAAAAAGAAGATACCTATACTTTAGAAATAAATAAAGAAAAAATAATAGATAATGCAACTATTAAGGAAATAGGAGAGCATAAATACTTTAATACATTTTATAAAGTACATGCTAATACTCCTATTTCTTTTATTTTAAATAATAATAGTGGAAACAGTAGACAAACAATGGTGGATTTAGAGTATATAGAAGGTAATCTTATGGAGAATCCAGTAGAACTGCCTAAGATACCACCAAGAGGTGATATTTTATTTATGCTAGATACCACTGGTTCCATGGGAAGAATTTATAGTGAAGGAACATCTTTTTTAAATAATTTAACAGAATATCTTGCAAATTTGGCGGATAAAAATCTTATTTATACTATCTTCTTTGGAGATATTAATAAAGGAAACTTATTAACGTATGATTACACAGAAGTTCCTCCAAAGAAGATAGATGAATTTAGTGAATATGTGAAAAACATAGATAATATCACTTCGATAGGAGGTGTCAATTCTCCAGAAAGTGGGTTAAAAGTATTAGAACTTTATAAAAACAAATACGAAACAAATAAGAAAATAAGAAGTATTTTTATAGCAACAGACGCAGAAAAATTAATAGGGGAAGTAAGTGGCTTAATTAGAGAAATTGATATACCTATATTTGTATATATCCCCGAACATGTTGCTGCAAACCCTGACAACGTATGGGAAGAATTACAGGAAGAGAACAAAGCGAGAATTATAGGTACATTTTAATATGGGAGGTAGATAATATGGCTACAGAAGAAAAGTTTTATTATGTAGAAGGCAGTTGTCAAGTTAAAGACTTGGTAAAAACTTTAGTAACAGAAATAACGCAAAATGCAGGAATTTATAAGTGGGATTTAGTACATCCTGCAAGCATGGACAATATAGGAAGTGCAGGTGAAGCAAAAGAAATAAATCTTATTACAGATGAAAGTACAACAGATAAGGTAGATACTGTATTCACAGTAGGTACACAAAATGATATGTGTATTATTAAAGCTACTACTAGCTTTGGAAAAGAATTTTATGTGAAAATAGATAGAGAAAAAGCAGATTTAACAACAGAGGAAAAGAAAGCATTAGTTGATTTTAAAAGTTTACATAGATATTGTATACGGGAATATTGTTATGATAGAACAGATGCACAAGTATTAGAAATAATGGCAGGTGTAAATGATGAATCAAGTAAAAGTGGAGATTACAATGCTTACGTAAGTGCCATGACAAAATCTAATTCAATCAATAATATAAGATTACAAATATCAGATAAATTAAATAAAGAAGGTAATGATTTAGATATACCTAAAAATATGCAAAAGGAATATAATTATAGACTAGCTTGGTATAGAAAGTTACAACCAGAAATTAAGGACTTTTTACCAGTTCAATATTGGATCAATGTAACTAAAGATAGTATAAATTTAGTTTTGCGTGGAGATCCTTCGGCAGATGTGCATCCATATGAAAACTATTTAACATCCTATGCTTATATGGGAGCATTAAAACCAGTTGAAGATAGTGCTACAACAGATGATAAATATAATTTTGGTATAACTGTATCTTCTGATATAGAACCTAATTATACAAAGCTCTATGGAGAAAGAACAGCTACTGGAGTAACAGATATGTGTATGATAGCTAATAAAATAGGTATGCCTTATCAGCCACATTACCCTGCTTTCTATGCTACTAATCCATTTATGGACAAGTGTAATGTAGAAGGTTCGAGATGGAATCATAAGAAACATCAATTTAGCGATATTACTTTAGTACATCCAGTAGATATGGAAAGAGGAAAAATGATCAATGTACTTGCTGGAGATGCTAGTGCAATATATGATATGGATAAATTAGCATATAAGAAAGATACAGATGAAGAAGAATATTACAAGAAATTTAAACTCACAGCACCTTTTAATTTTCTTAATAATAGTGCAAATATTAATTATTGTATAGCTATAAGGTGTTATAAAACAACAGAATAGGAGGTTCTTTATATGCCCCTACATAAAATACCCCTATGTAGTCTTAAATATGTAGGGGATACTCATTCTGGTGCAACTTTTAAATATGATACTACAAGCAAAGTGTTAAAACATAAAGAAAAACTATTTTATAAGGATAAGGTAGTTGAAATAGATAAGACTAGAGGAGATAAACTCTTATATAAGTATTTTTATAATATAGAAAAGAAGAATAATGAATATTTATATAAAGAAAATCCCATTATGGTAAAAGAATTTGAAAAAGAGCTAAAGTTGCATGACAGAGAAATAAATAAAGATAAAAGTATGCCTTTAGAAGATACAGACATTATAGAATTTAATAAAAAGAAAAGTATGCAACTAGGGCAAAAGGAATGTATAAATATAAACATAGAAGTATATACAGAACTCCAACCTAGAGATAGTATAGATATACATGTAGAAACAGACAAGAATTTACTAGAGTTTAGAAATATACAATTAAATAAAGATAATAAGTGTATAAATCTGATAAATATTTAGATTATATGCCTTTAATAAATGTCTATAAACAAATAGAAAAAGATTTATTAGATTTAACTATTTGGGATATATATAAAGAACATGATGAGCAATTACAAGGTACACTCATGAAAAACATATATAAAGTAGGCAATAATAATAAATTTATTGAGGTGGCCAAAAGATGGTGGTGGCTAAGTCCCACAGATCCAATGGATAAATTAATTATTCCTAATAAAGACTATGAAAAAATGAAAGAGCTATTAGAAAATCCTAACTATGAATATCTAAGATATAATGATCATCCTATTGAATGGGGTAAATATTGGGGAATAGATTATAATATCCCACCTATGCCAGTATCAATAGAAATAATGGTAGATTTAATAAATATATTAATAATGGTATGGCATAAAAATGTACAAGCTTGGATGTATTGTAGTGGCAAAGAAGCTGTACAATTTATTATGGAATTATTATATGATTGGTATTCTTTAGATACATCCAAACCTAATAAAGACTATATTAGAGCTTACAGGTGGGTTAGATGGGAAGCTGAAAAAGTATATTTCTTAAACGCTGAAAATGGATTACAAGCTATAGGAATATTAATAGCTAACTTAATAGATTATATGAAATACCATCATTTTGATTTAGTCCCATTATGGAGAAATCCAAAAGCTATGGATATAGAAAGAAATTTTAATAGGATAGTACAAAATGGAGATATTATGAAAGATTTAGACAAACTAAAGAGCAGTAGACACTATTGCATTGAAACGCAAAATTTTGAAAGAAAAAATATATTTGGAGAGTGATAATATGTTAGAAAGCACAATAGATTTTAAAAAACCAAGACAGAAGATGTGGGGAATATTAAAAGATAAACAACTAATATCTTTACCATATGGACATGAAACTAATGAAGAAGGAAAAGAATTAACTAGTTATGCAACTAATTGTTATGAAGATGCATTAGCAGAAGCACATACATTATTAGCACAAGGTACAGGAACCAAAAATATACAAGTGGTTGAATTTGTACCATATGATTATATTATGCAGCCCAGAGTTTAATTGAGGTGGTAGTGCATGAAATTAATAAAAGTGAAGGATGGAGCATTGGAGGTAGATAATTTTTATCTTACCTCTTTTTTTAATGACTTTGCAGGGAATTCAAATGTAACTAGAGATATTAAAACAGGTAAGTTAAAACTAATAAGTAATAATAAGATGGAAAGAAAGTTCGATTATAATGAATTTGTTATAGAGCTAGAGAAAGAAAATTTCAAGCACATGAATGACTATGATTACTCTATGATTTACTTAGGGAATAATGAGTATACCTTTGGTATTAAAGATGAAGAATTAGATCAACAGAATAAATATTGGAAAATATTGAAGCAAGATAATTATATACAAGCTTATGCAAGTCCAGATGGTATGAATTATAAAAATATAGGTGGTATGAAATTCGATGAAGCTATGACTAAACAAGGATTTATGAAATATAGTGCTGAAGATTTTATATTAAATAAATATAGTGTTTATGATAATCCTTATATAACTATTCAAAATTTCCCTGAAAATACTATTTGTGAATTGTATGATTTAAAAGGGAATTTATTAAAGACAAGGATATTTGATAAGAACTTAGAATGTAAAGTATTTATAGATGGTAATATGATAGGATATTTTATATTTAAAGATAAAGACAATAATGAGATTTACACTACAAGTCATTTATCTTTACAGTATGGGGATGTTTATATATGTAGTCCTTACAATTTTGAAATTATATATCATGGTAATGTGGTTACTAATGTGAATCCTGCTACACTCCAAGATTTAGAGGAGCTTATAACTATTAAAAACATTGGAGATAAAGATTATACAAACATCAATATAGGCACTGAAACAAGCAGTAATGACCTGATACAATTGTCTTTTGATGGAGAAAACTATAAAGAGTGTTTAGTTGTAGATAGTATTGAACAAGGTGAAAGCAAAGATATATTTGTAAGAATAACTAAAAATGCAGAAAATCACAACTTTAATGTTAGAGATTTTCAATTAGTTATCAATGAATAGAGGTGATAATGTGAGCAAATTTTTTAATGTAACACATGACAAGGATATAGTTTTAGATGATAGTATAATATCCAATAAGACTGGCTGGACAAGTAAAAAAATACATAAAGAGATAGTAGATAAAAGAATTACTAAATTTGAAGAACTTGAAGATGTAGATGTAGTAAACAAGCAGGACAAACAACTAGTAGCTTATTCAAAAGATACAGGTAAATTTACTACTATAAATGGAACAGAAGCAGGAGAAATTACAGGTGCAAGCATGAAGCAAATATCTAAGATGGGTGTTATAGGAAGTCCTGAAGAACCTAGAATAGTAAATATATCTGTTAATACAATAGATTTTAAAGTGCCCCGTGTAAATGTGCTTAAATATGATTTAGGCACACAGAATATTATATTAACAAAGAATGAATTTACTAATGGTGAATCTAACGATTTTGAAAAAGATCCAATGATGGTGTTTGATGGTAGGGCACATCTAAAAACAGAACACGCATCTAATTTCACGTTCAATAGGGGAATAGATATTAAATCAGAGTATGTTGTTATTTTTAAAAAGTCCAATTTTAAAAAAGTAGAAGGTTTCAAAATTGGGGAAGATGGGGTTATAAAAACTTTAGTTACTACAGCTATACCCCATGATAGATTATTAATTCCAAAGGGTGATATGAATTTAAGTAATGTAGAGAATATAGACTATTTTAAGCTTACTGCTACAGGTGAAAATATAAGGATAGTTTGTTCAGTTGATAGTGGACAAACATGGAAAGTATTTAAAAATGAGAAATGGGTAGATATTAATTTAGATGTAGAGGACATAAGAACTAACGGGATGACTATTGACTTATTTAACTCTATTAATGATGTATTTTGGAATGAGTTAGTAACTACTAAAAAGATAAGATTTGCCTACTTATTATCCATGAACAATATAGATAATATAGAAGAATTAGAAAACCTTGACCTTCAATATGACGGTGAGGGTAAATGGATACAAGCTAAAGAAGATACATTTGATGTTGTATATGCAAGTAATACATTATTACAAGTACATGTGAAGTTTAATGGTGATATAAAAATCAATTATTGAGTAGCCGATTTATTTGGCTGCTCTTTTCTTTAAAAGATAGATTCTAAATAAGACTTTATAGAAAGGAATGATAACATGGATAAAAACTTATGTGTAAACGGTACGGTTATTGCATCGAATGATTATCAACCCTCATATCCTGAAAGAAAGAAGGAATGTGTATTTGATGGAAATTTAGATACAAATTGGGGTGGCATTACTGGACAAACAATAGATAAATCTTGGATAGGGTATGATTTTTTAAAACCAACAACAATAATAAAAATAAAGCTACATCAATCTAATAATAGTAATTCTTCTATAAATATAGTTTCAGTGCAAGGTTCTAATAATGAGATACAATGGAAAGAAATTAAACAGTTTTCATTGATTCCTGGATTAAATATATTAGATTTGTCAACAAATAATAAAGCATTTAATAAATATAGATTAGTGGCAAAGACAGATGTAGGTATACCAACGTGGGCGTGGTTAGTAAAAGAAATAGAAATGTACGGGAATCTATATAAATTTTTACTTAAACAAAACTCTAATTATTACTCAATTAAAAACAATTTTTATAAACTTGGACAACCTAATGATAATGCACAATTAGAGCAATGGTATGATAAATATGGAACAAAGAACGTTAATACTATACTAGAACCATTAGATTTTAAAGATGTTCCAATGAGTTTAGAGGAATCTACGGGAATATGGAAAACAGATTTTGAATTAGATGCTAATAAGATTCTAGGCAACATTAAGATGATAGAAGAAAGTATAAAAAACGAAGGAAATAAAACAATTAGATATGAATGTGAACAATATAAAATTTATGATAAATTAGATAATGAATTTGAAATAATGATGGCTGATAACAAGTAAAAGAAAGATGATTTTCTTTAATAAATAGAATTTAAATAGAATGGGAAGGTGATAACATGGCAGGAAATACAAAACCACCTATTTATAACTTAGGTAAAGAAGGAAAAGTAGTTTTTATTGAGTATGACAGCTCATCTGGTCGAGACCATATAGACACTCTATTAGATGGACGATTAGATAAGCATGGTAGTTACGGGGTTTTGTTGTCTTCTTATGGTGCTAGACATATTATATTTAGTTTAGAGCAAGACAGTAACTTGTGGTGCTATGGACAGTACTACAGAGATTCAGGAGGAAGCACATCTCAACCTGTTACTATATATAAAGAAGTAAATGGAGAATGGAAAGTTTTTAAAAATGAAGCTAAAACCGAAAATGATAAGTGGTATATGCTATGTGGAGAAATGAGTAAAGGAAAATATAAAATAGAGACTACAGGTAGATATACTATGTTTACAGAGTGGTATACTGAAAACTTAGAAAGATATAAATTTTTAGTCAAACAAAATAACAAATATTACTCAATTAACCCTGAATACTATAAAGATGAACAATATCAATCACTAAGTTTAAAAAGCGAAGAATATCCTAATAATAATGATTTTAATAAATATGGCTTTAATAATTTAAATGAGTTGTTAAAAGAATATAAGAAAAGTAATATCAAGTCTAGTGGAAGCGATTTGGGTTTTGGTAAAGTGTTTAGCTTTAAAATAGATGATAATTTTAAATGTGTAAGTAATTTGGAATTAGTAGGTGAAACTTTAAAGTGGAGCAATGATGTAACTGATAGTTTAAAAAAAGAAAATTTTACTTCTTCTAAATATCATACTGGAAGATATAACTATATACCATATTTAGCTTTCGATAATCATATTGATAATAATGGTATGACAGGCTTTCAAATAAAAAACCCAAGTGATAAAGATTGGTTAAAAATAGATTTCGCAAAACCAGTTAGACCTTCAAAACTGACTTTGCAAGGGAATGCAGGGGATGTCAGTGTTTGTGTGCCTAAAAAAATAGAAATTTCTATGAGTAATGATGATATAAATTATACAATAATAGATACTATAGATAATATTATAAAGGATGATAAATATAATGAATATGTTTATAAAAAACCTATAAAAAATATAGATATTTAAAGATAAGGTTTTTAGAATTTTATAGTTCAGTGTGGTGTACAATTAATCAGATGGAGTTTTTTGAATCTTTATATGTTGAAAAATACTTAATACAGGACAAGAATTTAAATTTATATACTTATAAAGATGATACCTTGACAAAGTTAGATAATAACTCTGTAACAGAAAGTAATTTTAAGGGAAATGGATTTACTGAAATTGAAGTTATAACTAGAGAAATGCTATTAAACCAATTCGGTAATTTAGAAAATATAAAATTATTATTATGGACAGACAATATAAACAAAGAGGAATGTATTATGGAATATCATTTAAAAAAGCCACTTAGACCTATAGATATGCTAAAGAAGAGCAATAGTGGGAAGTTTGATATAGTTATGATGGAGATATAATAGATTAATCAATAAAAGTAGATTTAAAAAGAATACTAGACTAGAGAGAGTCTTTTTTTAATATAAAAATAAGAGCAATGCTATGCTATCATTGCTCTTATTTGAGTGAAGGAAAATATACTATGAAACACATTCATTAAGAGTATAGACGGATTTAAAAATAAATATACAGTAAGAAAATAATTGAAATCTATTATTTGCTTTTCAATAAAAAATAAGAGCAATGCTACGTTGCCATTGCTCTTTTATCTAGGAAAGGAATTTTAATATGAAACTATGACTATTAATAGTATAACCATAATATTACTTTTATACAATTATTTATTTTAATAAAAGGAGCAGTGTATTATATAGCACTGCTCTTTTTGAGTGGATTGAGGATAATTATTATCTATATGTTCGTGTTAAATGAAAGAGTTTATAGAAGAAAAACGGGAAGGAATTCTAGAAAGATAATTAATGTATAAAATCCACATTTTTCATTTTAGATTGACAGGTTTTCATATATCATCTATACTATATAAGTGATGCAAATACTAAAAAGAAGGGTTTAAGGGGTTAGAACAGATATTAATTTTGAAGAATATAAAAATTTAATTGGAAAACTAAGTAGTCTAAAAGTAAGAGAGTGGTATATTTATCATGATAAAAACATTGTTAATAAAATAGATAAATCATTAGAAATAAAAGAGCAAGCAATAAAAGCTCATTTGCTAAGAAACAAATATAGAATGCAAGCCAGAAAACTAATGAAAGATAGAGAGTTAGCAGCATATTTGGATATTAATAATTCTAATTTACCATTTGAGTATTATGAAAATAAATATTTAAAACAAGGATACACTGGTAATTTACTTTATAGAAAAATATTAGAAGCTTCAAATAGAACAAATAAAGAAGTAAATAAACAATTAGGAATAATATAATAAGAACTAGAAGGCACTCAATAAGGTGTCTTTTTTATTGCAATAAAATAAAGAGTAATGATTGCCAATCACTACTCTTTTAAAATTATAAAGGAGATTTAATGTTTAAAAAAACTATTAGTATTATAGACACATCTTAAATTTAATATACAAGAAAAGTAATTAAAAATTTAAATAAAAATAAGAGCAATAATAACATAACATTGCTCTTATTTTTGAGAAGGAAAATATACTATGAAACACATTCGTTAAGAGTATATACTAAATTTAATTTTTATATACAGTTATTGATTTAAATAAAAAAGAGCAATGTACTGAAACACTGCTCTTTTAATTGAAAGGCGGTAATGATTATGAATATGTTGATATTAGGATTATAGACAGATTTTAAATCAAATATACATTAAGAAAATAACTAAAACCTGTTATTTACTGTTTAATAAAAAATAAGAGCAATGCTAAGTTTGCATTGCTCTTTTATATAATTAGGTAAGGAAAATATAGCGTGAATAACCTATAGTAAGATTATAGACAGATTTAAAATAAATATATAGTAGGAGGTAAGATATGGATGTAAATATACAGCAGGAGATACTAGAAAGAATTGTTCGTATAGAAACAAAAATAGACGGATATAACAGTACAAGAGAGAAGGCAGATGTAGCATATAATAAGGCTTGTCAAAACGAGAAAGATATAGCAGAAATGAAAGATAATCAAAAATGGCTCTGGCGGACAATCGCTGGAGCTATTATTTTAGGTGTTTTAGGTGCAGTGATAAAATTTAAATAGGAGGTAACTTTATGGAAATGAATATAATGGAGTTCATTACAGAACAGGCACTTATATTGATACCCACTTTATATGTTTTGGGACTAATGTTAAAACAAACTAAACAGATTAAAGACTGGACAATACCATGGATACTATTAGTTGTAGGTATATTAGGTTCTATAGCTTTAATTGGACTCAATGCAAATGCAGTAATACAGGGAATACTTACAGCAGGTGTTGCAGTATTTGGAAATCAATTAGTAAAACAAACTACAGTAAAAAGTAAGGAGGAGAAATAGTTGAGCTATACAACTAAGTTTATAAATAGTGTTAAAGATGGGGCTATAGCTTCACAGAAGAAATATGGGGTATTAGCTTCAATTACTATTGCACAGGCAATATTAGAGAGTGGTTGGGGTAAAAGTAGTTTATCAAGGGAGTGTAAAAATTTATTTGGAGTAAAAGCTATAGGTGGATGGAGAGGATGTAAAAAAAGTTATCCTACATATGAATATTACAGTGGTAAAAAAGTTTTAATAAATGATTACTTTAGGGTATATAATAGTTATTCTGAATCTATAGAGGATCATGCTTTATTTCTAGTAAATAATTCTAGATATAGACAGCATGGTTTTTTTAATGCAAAAGATTATGTAGGACAGGCTAATGCTTTACAGAGGGCAGGATATGCAACATCTCCTATATATGCACAGCAGTTAATCAATCTAATAAGGCAATACAATTTAAATGAGTATGATAATATAAATAATTCCTACATTAATATAGATGGTGGAGGATATGCAAGTTACCAAGGTGGAGCTCCAGGAATAAATCTAATAATTAGAGATTATAGTAAAGATATTAATAGAATATTCGCTTGGGTGGATAACGATAAAGGAGCAAGCTGGGCATTTGATTTAACACCACCTAATAGTAATTACACTAAGTTATTTAAAAACACCAGCAAGGTAATAACCAAGAGAAATGGTGGGTATACTTTTTCTAAGGGTTCCATGTATAAGCTAAAAGTAAAAGGATATAATAAGTGTGGACAGGTCATAACAGAAAATCAAATAGTTCTAAAGGTACCATTAAAGTAATTTTAAAGCCATGGGTTAGGAAACTAGTCCATGGCTTTTTTATTTTAAAAATAAATTACATAAATATAGAAATAAATACATAAAAAGTATTGACACTTCATACTACGTGTAGTATAATATAATTAAAGGAGGTGAGAAAGTGATAGAAAACATAGGAAAGACAATAGCCCTAGTAATTTCATTACTAACAATACGGCAACTGAATTTGCAGAACAGAAAAACCGAGTTAGAAATAAAAAACTAAGGCTAGAAATCAAAAGGTTAAAAGAGGGGGAATAAAACCCCTCAACCTTTCCTATATTATATCACATTATCATATGAGTAGACTGTTAAATTATTTAATAGTAATATCAATTGTAGTAATACTATTATTATGGTTTAGATTAACATACCTTAAAAAAGAAAAAGCAAAACTTGAAATAGAGAAACTAGAGGTTAAAAAGAAAAAGGATGATAAGAATGGAAAAGAATAAACAAACCATAGCTAATCAAAAATGGGAAAATAAAAACAGGGAATATGCAAGTTATTTAAAAAGCCGATCTAGCGCTAGAAGCTTCATAAGGAATAAAGCAACACTAGAGGACTTGGAAGAGTTAAAGCAACTAATAAAAGAAAGAGAAGAAAATTTAAATAGTAATTAATCTTTAGGTAGCTAGCCGCTACCTCTTTTTTTATTTTTTGAAGGAATTTATAATAATTTGTAGAATAATATACAAAAGATGAAGATATTAACAACATGAGAAACAGAAAACACTATTAAATAACATTAAAGTGTTTTTTTAAAGTTAACTGTATCTCATGAAAGTTTTATTAGTATAACATATTTTGGATAAGCTATGAACAAAATGACGGAGGGAATAAGATGGAAGATAGAAAAAATGTTATTGCATTTTTAAATATGAAAGGCGGAGTTTGTAAAACTACTTTATGTAAAGAAATAGCATATACACTTACAGAAAAGTTAGAAAAAAAAGTTTTGGTTATTGATATAGATCCTCAATCTAATTGCACTCAGGCTTTTTATGAAAAATATAATGTTATAGAAGGTGAAAGTGTAAAAAAATATATGGAAATAAAAAAAGACTTACCATCAATAGAAAATATATTTTCAAAACCAATTGATATGGTAAAAAAAGCTTCTATGGATCATATTATAATTTCATTTAATAATAATTTACATATGATTCCTAGTAGTTTAAATACACTTTTTATGGACAGAGAAACTTCTAATGGAAATGATCAGATTCTTTTGAACTTTATAAAAGATGAGAAATTAAGGATTGATTATGACTATATATTTATAGATTGCCCACCCACATATTCTTTTTATACAATATCTGCATTATTAGCCGCAGATTATTATTTAGTACCATTGGTACCAGATATATATTCTATGTTAGGATTGGATTTATTAAATAGGGTTGTTGAAAAACTTAATTATAAATATAAGGCTATATTGGAACATAATCCTTTAAAAAATGTGGGGGTTATATTTACAAAAGTTCCGACAGAAAAAAGAATAAACAAAAGTATGCAAGATAATATAAAAGATATACAAGATGAATTTAAAGATATATACTTTTTCGAGCAAAAATTTCAATATTCAAGTAAATCTGCTAATGATAAAATTGAAACATTTATAATAGATAGAAATGATAACGCTTTAGTTAATAATATAACTCTTATTTGTCATGAATTTATAGAAAGGATGGATAATCTTAATGGAAAATAA

Protein sequences of DBSCAN-SWA_2

>NC_022777|1119025:1169373|1129076_1129334_+|WP_045923668.1|DBSCAN-SWA
MELEYDRYGRAKYNPFIHRNTGKPWSNTDLNYLINWYDIIGPDEMSFVLERTIATVMNKVYILRKKGVMNKHKRIRNCKRVRSMH
>NC_022777|1119025:1169373|1125744_1126353_-|WP_023437935.1|DBSCAN-SWA
MEFYKILQNIMSENNLSIPDISRATGLSDSTLRSMISRKTKNISLDVAFKLSEGLGISLEKLNGETPINSEATTINVSDKQNMKEIINRIKTRRNELMLSYQDLADKTGLSKSTLQRYETGAIKNMPLDKLGVLAKALNVSPAYLMGWEESVTDNDKEDTKKTTLLTNFNKLNETGKDEAIKRVEELTEISRYKDFIELDVR
>NC_022777|1119025:1169373|1119025_1120243_+|WP_023437927.1|DBSCAN-SWA
MNKPEILAPAGNLEKLKTAILFGADAVYLGGSKLNLRAFADNFTDEELIEGIEFAHSRGKRVYVTVNVFPHNEDLEGLEPYLKDLENMKVDAIIVSDPGIIMTAREVAPKLEIHLSTQANNVNWKSAIFWHKQGVKRIVLARELSFEEIKGIREKLPEDCELEAFVHGSMCMSYSGRCLLSNYMTGRDANRGECAQPCRYKYYLMEEKREGQYFPVFQDERGTYILNSKDLCMIKHIPELGRCGINSFKIEGRMKSSYYVASVVKSYRQALDAYIEDTKNYKFNEDWMNNLLKTSHRDYYTGFYLGDKDSQIYETSSYIRNYDIVGIVRDYNKETNEATIEQRNKLFEGDSVEVLRPVGDSFQVKLENIRNEKGEKIESTPVAQMIYKAKVNIELKKNDMLIKAK
>NC_022777|1119025:1169373|1126776_1127580_+|WP_023437937.1|DBSCAN-SWA
MNNLQIFNNKDFGEVRTIIKENGIWFVGKDVAECLGYKDTDQSLRNHVDGEDKLTRKIDGAGQSRRMTIINESGLYSLVLSSKLPSAKKFKRWVTSEVLPSIRKHGMYAKDELLDNPDLLIQVATKLKEEKAKNKMLELQNKQKEQIIGELKPRADYTDRILKNKGLVTITQIAKDYGMTGIGLNKLLHELKVQYKQSDQWLLYKEYSGKGYTHSETIDIVRSDGRPDVKMNTKWTQKGRLFLYNLLKDNGILPTIEEEAEREVACN
>NC_022777|1119025:1169373|1148200_1148503_+|WP_023437970.1|DBSCAN-SWA
MTIPLEILKFNLQEREYPYFEDNDLSLLLQSNDNNINKASYKGCLLKANADDKLEVAGVKLSSNRQYWLGLAEEYKKAYEESLQGNITGYKTSMKRVDGQ
>NC_022777|1119025:1169373|1153626_1154025_+|WP_023437978.1|DBSCAN-SWA
MDFNLQLKYDNGTDTGAVITNYKPPVPVTLRKGNKSLTGYTVFQDAVKSDTLIKFSVAFETHTPEEISKFKEFRSKYNERFIFIDEFGTEYRGYFQGNFDLDTPIEGDIYYMSCELLCPCPITGWEGDSNEL
>NC_022777|1119025:1169373|1137052_1137202_+|WP_023437952.1|DBSCAN-SWA
MGTIYLSTMSTVFTKGILLKGDNITIYGILSYFHNTHKEKTVVTVDKIS
>NC_022777|1119025:1169373|1155852_1156413_+|WP_023437981.1|DBSCAN-SWA
MGLPSYVINFDELSDLIKDYLENGINVDIGNITLNTEDIERLLSEIKDKIQGVDYNNLIQALNDLGAKLDGLSGNLGILGTQKIYGKMLEVPAIVGQHTIEFTAPANSKLTGITYSQSSWRFEDSWDLVVEEERLFTETRTKEYGEHKYFNVFYPVDGTIKFIYNNNSGASKVVWVDFCILEGGSE
>NC_022777|1119025:1169373|1164498_1164840_+|WP_023437991.1|DBSCAN-SWA
MEFFESLYVEKYLIQDKNLNLYTYKDDTLTKLDNNSVTESNFKGNGFTEIEVITREMLLNQFGNLENIKLLLWTDNINKEECIMEYHLKKPLRPIDMLKKSNSGKFDIVMMEI
>NC_022777|1119025:1169373|1124691_1124976_-|WP_023437932.1|DBSCAN-SWA
MENEKIFELIEKMYIDLKGSQEKMYADLKEGQRKICTELKSEISEVKKTVIRIENDHGKKLEALFDGYKQNSEKLNRIEDEVAKHKEVIIKRIK
>NC_022777|1119025:1169373|1132589_1134554_+|WP_045923669.1|DBSCAN-SWA
MDTLAIDVETYSNIDIKTYGVYKYVESPDFEIMLFAYAFNDEPVEIIDFMNGEKLPCNVFYALTDPNIIKTAFNANFERNTIKNQYPALCPPEQWECTMVKALTLGLPSSLDMVGKALNFEEDKQKMKEGKALIQYFCKPCKPTKSNGKRTRNLPEHDMEKWELFKEYCKRDVEVEREIRNLLNRYKTTEEEKKLWQLDQRINDRGISTDLILIKQAIECDADYTKRLIHAATKLTGLENPNSPTQIKKWIGERIGREVKTLTKTSIPELIKESESLGKSEVIKMLELRQLMAKTSIKKYESMNKARCKDGRVRGLLQFYGANRTGRWAGRLVQVQNLPQNHLPDLDDARNFIREGKFEEVEFLFDSVPDTLSQLIRTAFIPKEGNRFIVSDFSAIEARVIAWFAGEQWRLDVFSTHGKIYEASASQMFKVPIEDIKKGSELRQKGKIAELALGYGGSVGALSSMDRKRSIPEEELPGLVKSWRNANPNITKFWWDCDKAAKKVIKERTTVCMQYGLKFIYDPGVLFIQLPSGRKLSYIRPKIEPHETFSGDKITYEGMEQTSKQWKRIDTYGPKLVENIVQATARDCLREAMFRVDKEGYKIVMHVHDEVVLDVPKDFGSVEDVNKIMGQPIKWAPGLPLKADGYECNYYMKD
>NC_022777|1119025:1169373|1145267_1145462_+|WP_023437964.1|DBSCAN-SWA
MNLWEYVGKTIKITCLSGNTFQGKCSDYTQAIDNEPEIASIGVDTESASYELYENEIKNIEIIN
>NC_022777|1119025:1169373|1161350_1162433_+|WP_023437988.1|DBSCAN-SWA
MSKFFNVTHDKDIVLDDSIISNKTGWTSKKIHKEIVDKRITKFEELEDVDVVNKQDKQLVAYSKDTGKFTTINGTEAGEITGASMKQISKMGVIGSPEEPRIVNISVNTIDFKVPRVNVLKYDLGTQNIILTKNEFTNGESNDFEKDPMMVFDGRAHLKTEHASNFTFNRGIDIKSEYVVIFKKSNFKKVEGFKIGEDGVIKTLVTTAIPHDRLLIPKGDMNLSNVENIDYFKLTATGENIRIVCSVDSGQTWKVFKNEKWVDINLDVEDIRTNGMTIDLFNSINDVFWNELVTTKKIRFAYLLSMNNIDNIEELENLDLQYDGEGKWIQAKEDTFDVVYASNTLLQVHVKFNGDIKINY
>NC_022777|1119025:1169373|1165571_1165766_+|WP_012047659.1|DBSCAN-SWA
MQARKLMKDRELAAYLDINNSNLPFEYYENKYLKQGYTGNLLYRKILEASNRTNKEVNKQLGII
>NC_022777|1119025:1169373|1160341_1161340_+|WP_023437987.1|DBSCAN-SWA
MKLIKVKDGALEVDNFYLTSFFNDFAGNSNVTRDIKTGKLKLISNNKMERKFDYNEFVIELEKENFKHMNDYDYSMIYLGNNEYTFGIKDEELDQQNKYWKILKQDNYIQAYASPDGMNYKNIGGMKFDEAMTKQGFMKYSAEDFILNKYSVYDNPYITIQNFPENTICELYDLKGNLLKTRIFDKNLECKVFIDGNMIGYFIFKDKDNNEIYTTSHLSLQYGDVYICSPYNFEIIYHGNVVTNVNPATLQDLEELITIKNIGDKDYTNINIGTETSSNDLIQLSFDGENYKECLVVDSIEQGESKDIFVRITKNAENHNFNVRDFQLVINE
>NC_022777|1119025:1169373|1127790_1128027_-|WP_023437939.1|DBSCAN-SWA
MLIPSNATSIPWTFKSWITNFKEVDLPIGDLARDIINDSNFPKDDTFGIIHEYICYKTTSSEVIETFVTTWNFYLATK
>NC_022777|1119025:1169373|1148499_1148865_+|WP_023437971.1|DBSCAN-SWA
MSKFNRGKISRQIYKQLEKKGLLKEIKILRNGKNAYGEKLEDLYVATIKGYYYRKENKINISSDTGATINTNYYDKLLVTYNEESKKIKQDDYLTLDGIKYKVIDTGNVENIVFDMYLNRM
>NC_022777|1119025:1169373|1122649_1123171_+|WP_082208648.1|DBSCAN-SWA
MRTKISLPEYYNNKHYLEGLKVYMFDSIINILGSNILLTAYVTGNNSFPKPLKAEEEKYYLKQLEKGDISAKGVLIERNLRLVAHIVKKYSFPGKDMDDLISIGTIGLIKAIDSFKIDRGTRLATYAAKCIENEILMLIRNNKKTKGEVYLQDPIGIDKEGNEIPWTSYQSRA
>NC_022777|1119025:1169373|1167957_1168113_+|WP_164968049.1|DBSCAN-SWA
MSRLLNYLIVISIVVILLLWFRLTYLKKEKAKLEIEKLEVKKKKDDKNGKE
>NC_022777|1119025:1169373|1139213_1139762_+|WP_023437956.1|DBSCAN-SWA
MTTKETLEEIVKRVIKEYDKQQREKAKKKRDRRLRNTDLLLRNYDNLIKHIDYAIEDEKELKAEDPEELLDEIEEEINLENDEDYEGIYINAIKRTKTRTRIILKHIEVAIEFYRQKTKLSNSTNETRRYTVIYKFYFEKKKIPQIAEELGYSNKTISRDKKRAIEELSVLFFGIDGIKFSL
>NC_022777|1119025:1169373|1162508_1163300_+|WP_023437989.1|DBSCAN-SWA
MDKNLCVNGTVIASNDYQPSYPERKKECVFDGNLDTNWGGITGQTIDKSWIGYDFLKPTTIIKIKLHQSNNSNSSINIVSVQGSNNEIQWKEIKQFSLIPGLNILDLSTNNKAFNKYRLVAKTDVGIPTWAWLVKEIEMYGNLYKFLLKQNSNYYSIKNNFYKLGQPNDNAQLEQWYDKYGTKNVNTILEPLDFKDVPMSLEESTGIWKTDFELDANKILGNIKMIEESIKNEGNKTIRYECEQYKIYDKLDNEFEIMMADNK
>NC_022777|1119025:1169373|1137263_1137536_+|WP_023437953.1|DBSCAN-SWA
MNCDYKRKILKETLKILDSSYSIQTIDWSECLYRDLGNGIDFEIEYGKGKFDIYVWKNKSKTIECILDIKKADLKITLEGLIKKYGRIKN
>NC_022777|1119025:1169373|1149218_1149638_+|WP_023437973.1|DBSCAN-SWA
MSSFNYKVPGDHLQQDLINNTIPQTVWQKIYLHLKKLGYEVYSPGQKRDKCIDSYVVIKENGTYATNGNVTGYKLFDIIIYHPMSNYTSMEFYVENIKQAMKDIGELRPTGNETPSIIDEKIEAYTASIEYQQFKSLRR
>NC_022777|1119025:1169373|1128111_1128522_-|WP_155392350.1|DBSCAN-SWA
MLIRLIFLGADSMENKIYDLLEKMYVDFNQRFEDLEKTSSKIKSQVDTNSLMLEKIQTDIKTLAEVQQSFSEQLDRAKNKDGKTLGERLDIIELAISNTSKSVNDVVDAIDVIKETTGSHEMDIKILKKIRNNHSL
>NC_022777|1119025:1169373|1137516_1137792_+|WP_023437954.1|DBSCAN-SWA
MEESRIEKRLKKEIEKLGGKALKFVSPGMSGVPDRIILLPQGRIVFIELKAPGKKPRSIQKYRIKELKNLGFRVEIIDSIEGINNFIREIK
>NC_022777|1119025:1169373|1160071_1160326_+|WP_023437986.1|DBSCAN-SWA
MLESTIDFKKPRQKMWGILKDKQLISLPYGHETNEEGKELTSYATNCYEDALAEAHTLLAQGTGTKNIQVVEFVPYDYIMQPRV
>NC_022777|1119025:1169373|1168099_1168282_+|WP_023437996.1|DBSCAN-SWA
MEKNKQTIANQKWENKNREYASYLKSRSSARSFIRNKATLEDLEELKQLIKEREENLNSN
>NC_022777|1119025:1169373|1126496_1126745_+|WP_023437936.1|DBSCAN-SWA
MRQSNVIFANLRAEMARKQITIAKLAEEVGVNRDTMSRKLSGKTPLYLNEAFLINKKFFPNENIHYLFNELCKVSQKQDKKN
>NC_022777|1119025:1169373|1166839_1167640_+|WP_023437995.1|DBSCAN-SWA
MSYTTKFINSVKDGAIASQKKYGVLASITIAQAILESGWGKSSLSRECKNLFGVKAIGGWRGCKKSYPTYEYYSGKKVLINDYFRVYNSYSESIEDHALFLVNNSRYRQHGFFNAKDYVGQANALQRAGYATSPIYAQQLINLIRQYNLNEYDNINNSYINIDGGGYASYQGGAPGINLIIRDYSKDINRIFAWVDNDKGASWAFDLTPPNSNYTKLFKNTSKVITKRNGGYTFSKGSMYKLKVKGYNKCGQVITENQIVLKVPLK
>NC_022777|1119025:1169373|1151184_1153614_+|WP_023437977.1|tail|DBSCAN-SWA
MAINVGTAIAYLTLDKSPFNNGLKSAGAELKNFIRGTGEAGGRIKSLGGALTSVGGTLTKTVTLPIVGIGTACTKMASDFETSMAKIDTIAGASKKELADMRKEILKASSEYGMAAKDFAQATYDSISSGIDKADAVAFTKDSAKLAKAGFTDVATATDTLTSVINAYGKSSKDATDISNQMIIAQKLGKVTVDEMGASLGNVIPIASALGVKTEELFSSIAVATAQGIKPAQSITGLKAAMSNIVKPSKEAKKAAKTLGLQFDANAVKTKGWMGFLQDVKSKLEESAPTYAKKLDEVNKLKKAIESSGGSSKKYKEEIEKEREKIKVLREEKKNLTSKDKDRKKAIDNEIKSMQEHIKTMQKQSKAEKDGASNVKEMKKALKEKEKELKILEGTSKDTLSAFSTMFGSVEGLNTVMSMTSNSGVKLYDKSMKEMKEDTNATQEAFDKMMDTPEEKFKKAREQLHNLGITIGGYLLPHVSRFLDAFSKLLELIDKLPEPVKHSIVSFAGMAALSGPLMMLGGNVIKMGGNIVKGVSKIITGVAGGVKRGVGGIVKAFKLIPKAAGVFKTLPALITPHTFIIAGAILAIGFIVYEVIKHWDKLVAAGKKMGGILEKIFKGIGDTIKWVIGGWKLLIGHFINWGKEKLKNIKDGFINGINKVKGLFKGKGKELGKGVKEGFESELEIHSPSRVFVGYGGYIGEGLVEGIDKQEGSINTKFKGLANKIKDLGNVRPEFDGLNNLALSGAGSGYSNIGNSKQLNFNPTINMNVTVADTGGKGTEQLTQEVNSMGQVALKNGLVDLFMKDAVRN
>NC_022777|1119025:1169373|1166333_1166558_+|WP_023437993.1|DBSCAN-SWA
MDVNIQQEILERIVRIETKIDGYNSTREKADVAYNKACQNEKDIAEMKDNQKWLWRTIAGAIILGVLGAVIKFK
>NC_022777|1119025:1169373|1168503_1169373_+|WP_023437997.1|DBSCAN-SWA
MEDRKNVIAFLNMKGGVCKTTLCKEIAYTLTEKLEKKVLVIDIDPQSNCTQAFYEKYNVIEGESVKKYMEIKKDLPSIENIFSKPIDMVKKASMDHIIISFNNNLHMIPSSLNTLFMDRETSNGNDQILLNFIKDEKLRIDYDYIFIDCPPTYSFYTISALLAADYYLVPLVPDIYSMLGLDLLNRVVEKLNYKYKAILEHNPLKNVGVIFTKVPTEKRINKSMQDNIKDIQDEFKDIYFFEQKFQYSSKSANDKIETFIIDRNDNALVNNITLICHEFIERMDNLNGK
>NC_022777|1119025:1169373|1129781_1130033_+|WP_023437945.1|DBSCAN-SWA
MDKKVAIVRFPRGSFSQDYSYKTDIENLKEGDVLVVEANNSYAIAIFQRYSEDENKIKQATKWVVQKVDIEAFENRLFLGGDD
>NC_022777|1119025:1169373|1141903_1143361_+|WP_023437961.1|portal|DBSCAN-SWA
MNIKETLLNLNEREKKERKKALKDFIFYLGECENIDAAKLNQDLLGQNWITLDDLDYIPSQVIDNKIKPLINKQARFMFGKEPDILLKPLDKQNKETCEKLRQYIDAILNASKFWSNTMKAFRLATVTKRVMLRLEANPGQPIRLYYHDINDFSYEVDPNDITKLNKVILVRQDAETANKEEKDQIWCRYTYYMNKISDKESTCYLRIETFKGNNLEAPIEIKEQDTGLSKIPCWVICNERSIINPYGQSDIKDLKPLQDSYNRRLSDFNDSLRFLMFGQTAVIDATEDTVNACNIAPNSLMALKSIDDTEGNKQAKVQRLESNFTNADPVLKYLKTLEDSMYEKLGIPKPESLQQVPSAKSIKYMYIELVARCEEKWHDWEPIIRQMIRLIVEACGKFKCYEEWKDEWNDLLYNIVLNKNYPIPEDEEDKKRLAMEEVRTNVRSHRSYIKDFTDDENVDDILKEICEDITSITAAEQEQFLREI
>NC_022777|1119025:1169373|1148866_1149214_+|WP_162181052.1|DBSCAN-SWA
MMSFKFDIESVINGLSEFEVKSKVSIGVYADTAGKKLENHAKKNAPWIDRTGLARKTIEGGKQWEDDKCIVYVAGNMEYSPFLELCNDKQYATLKPAVDKLSPEILRGMNNLLGK
>NC_022777|1119025:1169373|1166575_1166839_+|WP_045923674.1|holin|DBSCAN-SWA
MNIMEFITEQALILIPTLYVLGLMLKQTKQIKDWTIPWILLVVGILGSIALIGLNANAVIQGILTAGVAVFGNQLVKQTTVKSKEEK
>NC_022777|1119025:1169373|1124993_1125254_-|WP_023437933.1|DBSCAN-SWA
MENLLKEILSEIKGIKETQEKMQSDITEIKEKVNAVYNQTADLTEFRTESIESLNQIKDDVEYLTHKESQNEKVLFNLQRKVTTNR
>NC_022777|1119025:1169373|1127606_1127786_+|WP_023437938.1|DBSCAN-SWA
MNLKNISTEDLIKELISRKNVEIYNCGLYEKHEAQIKRKYTQDRNPVKLPLHYKLIVVD
>NC_022777|1119025:1169373|1125281_1125740_-|WP_023437934.1|DBSCAN-SWA
MSYDTLLDEAFNNDIMVKEIDLKTKDGLCYGNRIAINKNLTTNKEKRCILAEELGHFYTTVGDITDQSKIVNLKQEVRARRWSYEKLIGIIDLVNAYNNGARDKYTLADYLNVTEEFLEEAINYYKTKYGLYYEIDNYLIYFEPTLGVMKIF
>NC_022777|1119025:1169373|1129407_1129761_+|WP_023437943.1|DBSCAN-SWA
MLVARIKQIKQESYSLSELRDLEDLIINNMGEDAWNAIMYFMEKKIGELEENSVYTEKDIKDYDLSLTALRSGVTEEIEIIEKLIDKVTNAKRLNRETLIKELNGISNRLYDNEGYF
>NC_022777|1119025:1169373|1148009_1148198_+|WP_023437969.1|DBSCAN-SWA
MAKKADEKLKKVKALVNIKYDESCFKIGYEFEVRSEDSEEMTKRGYVESLEKIEKGETKEGE
>NC_022777|1119025:1169373|1149642_1150515_+|WP_023437974.1|DBSCAN-SWA
MDGKTLVNVIKVNFIDEVTNIKHTIETSDEIDIEPIKSDGKRDILRVKNTIYGINETEDIVIGYKLKLKDNLFNMKTMSLIHGGSIEGNKYCGAEAGKVAERHPFTMEIFTEEKDYSRTTGYAKFTYKHCKGKPAKYKVKDGEFLVPEYEAESIPFRGEKPVEIEFLDTLPSKPEKPDPPVEDIGVEGGTVKDTNTDVGVEITNRIVWTFKEQINQDDVTKTNFSIRRKSDNSLVQGNVTIDGTKKIVTFVPTSLAVDTVYIAEAKEVKKLDGSGTTTSLDTEFKTVKIA
>NC_022777|1119025:1169373|1150531_1150942_+|WP_023437975.1|DBSCAN-SWA
MEITNLEQLKQMAECDVIELPRFKQEIPFVVKVKRVSILNLVRKGIIPNRLLSAAEELFYGKTSNKGNVDMKTLTDVMFIMAEKALVEPSIKDLEEVGLELTDEQIVALFNYTQQGVQELESFREEPEDNDGANDK
>NC_022777|1119025:1169373|1123160_1124669_-|WP_023437931.1|DBSCAN-SWA
MNKICIYLRKSRADEELEKTLGEGETLSKHRKALLKFAKEKKLNIVEIKEEIVSGESLFFRPKMLELLKEVENKQYTGVLVMDMQRLGRGNMQDQGIILETFKKSNTKIITPMKTYDLSDDFDEEYTEFEAFMSRKELKMINRRMQGGRVRSVEDGNYIATNPPLGYDIHWIKKSRTLKINTHECEIIKLIFKLYTEGNGAGSIAEHLNNLGYKTKFNNNFSRSSVLFILKNPIYIGKVTWKKKEIKKSKNPNKVKDTRTRDKSEWIVVDGKHEPIISMKMWNKAQEILNNKYHIPYQLVNGPANPLAGIVICSKCKFKMVMRKLKGIDRLLCRNNKCDNISNRYDSTEKAIVQALERYLNEYRINISNKNKTSNIKPYERQVNILEKELAALNEQKLKLFDFLERGIYDENTFLERSKNIEERITKTSSGIEKINDIINKEKKVIKEEDVIKFQKLLDGYKNTDDIKLKNELMKKLVNKVEYTKDKRGETFGIDIFPKLKP
>NC_022777|1119025:1169373|1150919_1151141_+|WP_045923587.1|DBSCAN-SWA
MTVLTISKQYKQRPSEIIGLTNDYEAFCFDEACIYIISKLQEEGSPKPKFIDDEDRNKTNNNDVIEWLNANNK
>NC_022777|1119025:1169373|1130326_1130800_+|WP_023437947.1|DBSCAN-SWA
MKITAEFNSSEELISFINTFGANALKGIESKKEVQEVEVKEVEVKEVKKETVTEKKEEVKQVDTPKEEVKKETVVEKKEEIKKEEKSNPLKNEQVKTVDTSKEKITKEMIRAAFAKLIKAGKAKEAKDITTKYGAKKVPDLKEEDYTAILKEVEELL
>NC_022777|1119025:1169373|1157509_1158748_+|WP_023437983.1|DBSCAN-SWA
MATEEKFYYVEGSCQVKDLVKTLVTEITQNAGIYKWDLVHPASMDNIGSAGEAKEINLITDESTTDKVDTVFTVGTQNDMCIIKATTSFGKEFYVKIDREKADLTTEEKKALVDFKSLHRYCIREYCYDRTDAQVLEIMAGVNDESSKSGDYNAYVSAMTKSNSINNIRLQISDKLNKEGNDLDIPKNMQKEYNYRLAWYRKLQPEIKDFLPVQYWINVTKDSINLVLRGDPSADVHPYENYLTSYAYMGALKPVEDSATTDDKYNFGITVSSDIEPNYTKLYGERTATGVTDMCMIANKIGMPYQPHYPAFYATNPFMDKCNVEGSRWNHKKHQFSDITLVHPVDMERGKMINVLAGDASAIYDMDKLAYKKDTDEEEYYKKFKLTAPFNFLNNSANINYCIAIRCYKTTE
>NC_022777|1119025:1169373|1143925_1145263_+|WP_023437963.1|capsid|DBSCAN-SWA
MNEYLELVDKAQKQRIMLTKKQIKNIKDLYRDVAKDLRKRAKRANKDSLSERWLLDYQKQFKKDIKELNKILKKDIEYSILESAKYATNIQTDFFNLMDVKYKLNSKETFSNMFSRIPQQALEELINGDFYKDGKGLSERLWFHEKEANANFDYIIQKGLLEKKSTYELAKDLSDYVNPEVKKDWDFKRIYPGVGNKKIEYNSFRLAVTSMSHAYQLSMQRSCKANPFVEGIEWHTSNSHRGPCSICREREGKTYKPDELPLDHPNGVCYFTPVITKSLDEVGMELHGWLYGGSNNKLDDWYKEYGREFAGENNLFRNISKKGNNNDSNSDIISSIRNDIKSGKYPLEILEGKQGKHIKEHNNYIEGRSYLTISIDEAQKIVNKYAGSGIIRLNQNNEWDNKEIVTIDKEIGINVNNMTNEESKTNRCKIHYSKKGTHIVPTKKE
>NC_022777|1119025:1169373|1140748_1141837_+|WP_023437959.1|DBSCAN-SWA
MILKENLSYPLVHYTDMYGNFIGFQKDKNSEVVLCSCMRKAVENCIKLFLKYPSSLLNPPEWILLKQLDMPESINDVIRKKNPPVGLEWLNYIKFKEEVCHRCNIEKPTKEYCTPMYGTKFKRTFGWYININYFNKGINPSTHDGIYYLKEDGPIEIKLILDPTDKDLLEDIRRYKLLDTFEDKEILDMLKKIKHREEAIVLRYFHIEDKELQYQKLYYAIEYVMKQRLKEVHKVIENEVRDWFKSKRVGEKWENETNLYKIIRKLYPELTMYRHFRPPFLDGLELDIYIETLDIGIEYQGEQHFKPFEHWGGEEAFEKRQELDKKKKELCEKNTIKLIYFNYNEEINEEHIRKKLLKELNI
>NC_022777|1119025:1169373|1130799_1131945_+|WP_023437948.1|DBSCAN-SWA
MAAHALLSASGASRWLACPPSARLEEQFENVSSEFAKEGTLAHELGELNLKLNLGEITKRKFNSEIKKIEENELFTKDMPDYVEIYVDTCMEKVAEAKAKTPDALFKIEQRLDFSEWVPEGFGTGDFVIIADGTMEICDLKYGKGVPVSAIDNKQMRLYALGAIAEFSFLYDIEKIKMTIIQPRLDSISTDEMMIEELLKWAEEELKPTAKLAYEGKGEFCAGGHCKFCRAKAMCKARADKNMELAQYDFQEPNTLDNNDIAFILSRADELIKWAADVQEYALEQALQGEEFDGFKVVEGRSNRKWTDESKIGEILLGQGFLENVIYTKKLTGITNMEKAIGKKEVTRLLGDYIIKPQGKPTLVPITDKRPVYNSAEADFK
>NC_022777|1119025:1169373|1120971_1122600_+|WP_023437929.1|DBSCAN-SWA
MLYNTFVFLISLGFLNLRLYNLQYKDRERYNVMANMQHSYVEPTRDLNYKLLDCNGDNLLKYKEEYKAVIIPKVFAKQNGEENYKEYLKIIEELELYNEDYNNLDITSNAKHYFTIDLPTYEKIKDIKNIKGFYTFKNLKVDRSEAWSLENMITTTKNISSGKEKSLDSLEMTIKNKLKNNKNYTIEFEKDVDNNILNIEENIPKNNLNVKLTLDRNIQGNIKELLKSKYGDYEQIGVILMESNSGNIKAMVQKDDTLPNINIGAETLNGFFPGSIYKTLVMETILEKDNDNVNKSFSCKGLYEDNNKGINHGSLNINDAFVVSCNHIFSQLGIESGFQSIHSLSKSQGLLDKVLNLDREQSGKFEIEEPKMENGSLGLTAIGQNIRITPIEAISIANTVINEGIYIKPNIISVYVDNANKVVEKTKYQGERCISKETALNVKKAMNGVVNKGTAREAYLEDIDIGGKTGSTERLEIIKDRNGKSKRIKYSDGWFIGFFNKEDKYYSMVVFVKNINKDSESGGNTAAPIFKDVVKIFLDKEH
>NC_022777|1119025:1169373|1134565_1136989_+|WP_023437951.1|DBSCAN-SWA
MEIKTKNNLDINIKYDGSIAIATGKSRKETHWKNKNILWSTLVDKLSKTTRTPETYAEYKKMSKSERDRIKDVGGFVGGGLKNGRRKAENVQNRTLLTLDLDYVNGDIWSSIELLWDFSVVMYSTHTHIPDNPRLRLVIPLSRPVLPDEYQAISRMVADDIGIDQFDDTTYEPSRLMYWASTSSDGEFIFKIQDEPWLNPDEILDRYTFGWQDVSYWPESSRSRAKLNSVIKKQDDPLTKKGIIGAFCRTYSISEAIAEFLNDVYTPGIDDTRYTYAEGSTTGGVVVYDDKFSYSHHGTDPASNILCNAFDLVRIHKFGHLDDEVRIDTKQNNLPSFKKMTEVAINDNKVKIQLGKDRIESVQNEFEVVKDDDIEWLKLLENDRSGRICATIDNAKIILQNDINLKNKLAYNEFSLRKSVKGSLPWYKSDKIRFWEDGDDSGLRHYLEKVYGIKRAAPNIEDACKLIFKENKFHPVRDYLNSLTWDGKKRVETVLIDYFGAEDNIYTRAAARIFICGAVARIFNPGCQLDYVTTIVGKQGIRKGTFYKTMAKYDEWYTELATIKYKEAIEETMGKWIVEMAEMAPTKKSEIEEMKAFITNKGKTIRLAYAHNPTDIPRQYVLVASTNEPSFLKDPTGDRRYLPVDADMDKATKSIVKDLRNEVDQIYAEAMVLYKKLKNKALMLNSEEEALASIEQDGHRIVDDEESTIIEFLETPLPRDWYEKDLYERQRYFNDSLSPKVTKEDGIIRDRVCVKEILNELYGVTGKVDLRDSARINKILQGLKSWQKQKTPIRISGYGNQRGYYRK
>NC_022777|1119025:1169373|1154014_1155532_+|WP_023437979.1|DBSCAN-SWA
MSYKLEVIKKTNGEKYTFKRLFLSADVDRRIDMGATQATFKISNNAPMKLTNFGGIDGIIDNSNRVNFYWNDEPQFTGTIKNYNIKSSEEIIEVIARDDYSKLLKPIDPGVPYLIYKDIMASDMVLDLCKRAGLKVQIKKDEIQDYKIEKEMKIKYDTQFSDVVEEAITTMESKGIMNKEGILVIGKPYPNYLASDVPNNINYNWYYEDFIKIADADSKRNTDTMYSRLLVKYNEKIYNVYEEPKMKKYLGGENRFTEVETVLADTEIKRRRIANKQFLDMWRRNTNLDIIATKANPKLKLRDVVRTKIKDDYLGHYMVVGIHTSFTPDSVNDQIALEGMRENTSLAVLSTGNYTIEGKKKGSNKNETYEDVKENVLESFNIDKTGKIKLGFADIEKQPYLEVKAFLNSLLETKHYDLVIQDPNKSFYGYKQQILGDSENIITKTGLNSCQSITYSGWSGQPEYFKITKPMPGRWYVYLQSDTSEEYKANISVNMPWKKVKIDEV
>NC_022777|1119025:1169373|1120273_1120903_+|WP_023437928.1|DBSCAN-SWA
MSKRPILIGITGGTGSGKSTVSKEICRRFDKELIVMIEQDSYYKDQSHLSIEERVKTNYDHPNAFDTELLVNHLKELSCWNKVEKPIYDFELHNRKNETEIVEPTEIIIIEGILVLEEKEIRDLLDIKIYVDTDADVRIIRRLVRDIKERGRSLDSVINQYLNVVRPMHMQFIEPSKRYADIIIPEGGHNKVAIDIIVGNIKQMVQKSE
>NC_022777|1119025:1169373|1130032_1130293_+|WP_023437946.1|DBSCAN-SWA
MDKNYEIIQDILFRAIQITVNQKQDVSWEFFSLSKTLSISISFNGECKEGLVKTYSVKVEDTECLKIIQDELINLQYGNLDDEFLG
>NC_022777|1119025:1169373|1131969_1132530_+|WP_045923586.1|DBSCAN-SWA
MIMIKAKRTGTKVTTGKVRLSYAHLFEPHAIEGNEPKYSVSVIISKTDTETLKAIKEATEQAKKEGASKWGGKIPATLKTPLRDGDAERPDDEAYTNCYFLNASSKNKPGVVDQNVQPILDATEVYSGCYARLTLNFYAYSASGNKGIACGLGNVQKLEDGEPLGGFTRAEDDFEAIETAEDDFLG
>NC_022777|1119025:1169373|1155521_1155851_+|WP_023437980.1|DBSCAN-SWA
MKFNDFRVPVEYIIDQYWRKKQLKDNVFFDEEEITDLPQYPVDIERNPDTKKVEKIIYDKGGTLEWIEELLRDWHNKVTRIKVTLPDQEVKYIDLVRDATGKVTRVEVN
>NC_022777|1119025:1169373|1145641_1145809_-|WP_023437966.1|DBSCAN-SWA
MSNLIKPGTDNQPAGKYKEVGPRGGNVPKARVVKIDPGDRLPPTQEKGRKWEKFK
>NC_022777|1119025:1169373|1146919_1147954_+|WP_011099336.1|capsid|DBSCAN-SWA
MNLQDFINANEIALYIKNLPLQVTLDKALFPNDKQLGMELEVAKGAKQRPVALRMSTFDVAVKPRTLKADINIEKKEMPFFKESVLIKEKDRQQMLLAMKANNQELVNQILNQIFGNYKALVDGAEVQATRMRAQLLQSGEIKIITDDGDVVVDYGIPSDHKEVLAGTAKWSDKTANIVGDIERWQNTLVAEGYAKPNRMLMTQKTFGYIRANAAIESEIKGISNVVVTDKLVKNYLKEKLEIEVGILNGVFTAEDGSTMNLYEDNKVTLIPQGALGKTMYGTTPEEADKMFGSSKLDTQIVNTGVAITTMAKEDPVTVETKVSQLVLPSFERADECFFATVAE
>NC_022777|1119025:1169373|1163356_1164448_+|WP_023437990.1|DBSCAN-SWA
MAGNTKPPIYNLGKEGKVVFIEYDSSSGRDHIDTLLDGRLDKHGSYGVLLSSYGARHIIFSLEQDSNLWCYGQYYRDSGGSTSQPVTIYKEVNGEWKVFKNEAKTENDKWYMLCGEMSKGKYKIETTGRYTMFTEWYTENLERYKFLVKQNNKYYSINPEYYKDEQYQSLSLKSEEYPNNNDFNKYGFNNLNELLKEYKKSNIKSSGSDLGFGKVFSFKIDDNFKCVSNLELVGETLKWSNDVTDSLKKENFTSSKYHTGRYNYIPYLAFDNHIDNNGMTGFQIKNPSDKDWLKIDFAKPVRPSKLTLQGNAGDVSVCVPKKIEISMSNDDINYTIIDTIDNIIKDDKYNEYVYKKPIKNIDI
>NC_022777|1119025:1169373|1145936_1146554_+|WP_023437967.1|DBSCAN-SWA
MPKLSEILGEHFKQIPEDLQKKYKDIDLVDSSNYVEKKELETANSSIKEYKKQLKDRDNQINELKEEYKDVDGLKDKLTKLEEENKNQKEEHEKQLAKIEFQNALNKALDNYNVKDKEVVTKLLDEDKLKQDGKDIIGLKEQMEIMQKERSYLFEEEQPGGTGSIGGGPSSFSNNTDQPKSIGEVLGKQQADQVKINETIDSFFK
>NC_022777|1119025:1169373|1146568_1146901_+|WP_023437968.1|DBSCAN-SWA
MRQSTTKILGTQRNILALAGALFQNTNIKVSKTVATLKEGILEAGTIVDKTGKKVTDGTAFGIVYEDVDFNNSSGTEVVPVTIFGFIKENALPQKPATEVKAALKMIQFL

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023437927.1|1119025_1120243_+	U32 family peptidase	Q6DW11	Phage_TP	6.3e-55	38.0
WP_023437928.1|1120273_1120903_+	uridine kinase	A0A2K9L178	Tupanvirus	1.3e-35	41.5
WP_023437929.1|1120971_1122600_+	penicillin-binding protein 2	NA	NA	NA	NA
WP_082208648.1|1122649_1123171_+	sigma-70 family RNA polymerase sigma factor	S6ANS0	Bacillus_phage	8.2e-12	39.0
WP_023437931.1|1123160_1124669_-	recombinase family protein	A0A0A7S054	Clostridium_phage	1.2e-284	99.0
WP_023437932.1|1124691_1124976_-	hypothetical protein	A0A0A7RW25	Clostridium_phage	6.2e-30	98.9
WP_023437933.1|1124993_1125254_-	hypothetical protein	A0A0A7RU12	Clostridium_phage	7.6e-11	67.5
WP_023437934.1|1125281_1125740_-	ImmA/IrrE family metallo-endopeptidase	A0A0A7RVV2	Clostridium_phage	3.5e-83	100.0
WP_023437935.1|1125744_1126353_-	helix-turn-helix domain-containing protein	A0A0A7RTR3	Clostridium_phage	2.8e-48	83.8
WP_023437936.1|1126496_1126745_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_023437937.1|1126776_1127580_+	phage antirepressor KilAC domain-containing protein	A0A0A7RW33	Clostridium_phage	9.1e-103	72.8
WP_023437938.1|1127606_1127786_+	hypothetical protein	A0A0A7RVL8	Clostridium_phage	1.9e-24	94.9
WP_023437939.1|1127790_1128027_-	hypothetical protein	A0A0A7RTK6	Clostridium_phage	5.4e-40	100.0
WP_155392350.1|1128111_1128522_-	hypothetical protein	A0A0A7RTF5	Clostridium_phage	9.8e-61	96.2
WP_045923668.1|1129076_1129334_+	hypothetical protein	A0A0A7S062	Clostridium_phage	7.5e-43	96.5
WP_023437943.1|1129407_1129761_+	hypothetical protein	A0A0A7RVM0	Clostridium_phage	4.2e-52	94.0
WP_023437945.1|1129781_1130033_+	hypothetical protein	A0A0A7RTK9	Clostridium_phage	3.5e-37	93.8
WP_023437946.1|1130032_1130293_+	hypothetical protein	A0A0A7RTF9	Clostridium_phage	3.9e-39	95.3
WP_023437947.1|1130326_1130800_+	hypothetical protein	A0A0A7RTD8	Clostridium_phage	4.8e-19	75.3
WP_023437948.1|1130799_1131945_+	DUF2800 domain-containing protein	A0A0A7S066	Clostridium_phage	2.1e-209	96.6
WP_045923586.1|1131969_1132530_+	DUF2815 family protein	A0A0A7RVM4	Clostridium_phage	1.7e-100	97.8
WP_045923669.1|1132589_1134554_+	DNA polymerase	A0A0A7RTL3	Clostridium_phage	0.0e+00	98.9
WP_023437951.1|1134565_1136989_+	virulence-associated E domain-containingprotein	A0A0A7RTG3	Clostridium_phage	2.6e-294	64.1
WP_023437952.1|1137052_1137202_+	hypothetical protein	NA	NA	NA	NA
WP_023437953.1|1137263_1137536_+	hypothetical protein	NA	NA	NA	NA
WP_023437954.1|1137516_1137792_+	VRR-NUC domain-containing protein	A0A0A7RTE1	Clostridium_phage	2.6e-25	96.7
WP_023437956.1|1139213_1139762_+	hypothetical protein	I2E8Y5	Clostridium_phage	3.1e-09	37.5
WP_023437959.1|1140748_1141837_+	hypothetical protein	A0A0A7RU01	Clostridium_phage	6.3e-208	96.4
WP_023437961.1|1141903_1143361_+|portal	phage portal protein	A0A0A7RW62	Clostridium_phage	5.8e-281	98.1
WP_023437963.1|1143925_1145263_+|capsid	phage capsid protein	A0A0A7RU06	Clostridium_phage	7.3e-182	85.9
WP_023437964.1|1145267_1145462_+	hypothetical protein	A0A0A8WJ56	Clostridium_phage	5.0e-15	57.8
WP_023437966.1|1145641_1145809_-	YjzC family protein	A0A0A7RTS6	Clostridium_phage	9.2e-26	100.0
WP_023437967.1|1145936_1146554_+	phage scaffolding protein	A0A0A7RW68	Clostridium_phage	6.4e-40	46.8
WP_023437968.1|1146568_1146901_+	hypothetical protein	A0A0A7RU46	Clostridium_phage	4.3e-51	97.3
WP_011099336.1|1146919_1147954_+|capsid	major capsid protein	A0A0A7RU11	Clostridium_phage	2.1e-189	100.0
WP_023437969.1|1148009_1148198_+	hypothetical protein	A0A0A7RTZ2	Clostridium_phage	2.5e-24	98.4
WP_023437970.1|1148200_1148503_+	hypothetical protein	A0A0A7S0R4	Clostridium_phage	2.2e-49	98.0
WP_023437971.1|1148499_1148865_+	hypothetical protein	A0A0A7RW73	Clostridium_phage	7.1e-55	90.1
WP_162181052.1|1148866_1149214_+	hypothetical protein	A0A0A7RU51	Clostridium_phage	8.8e-47	80.7
WP_023437973.1|1149218_1149638_+	hypothetical protein	A0A0A7RU17	Clostridium_phage	1.9e-67	87.8
WP_023437974.1|1149642_1150515_+	Ig-like domain-containing protein	A0A0A7RTZ9	Clostridium_phage	8.0e-153	95.5
WP_023437975.1|1150531_1150942_+	hypothetical protein	A0A0A7S0S0	Clostridium_phage	1.3e-49	73.5
WP_045923587.1|1150919_1151141_+	hypothetical protein	A0A0A7RW80	Clostridium_phage	5.9e-20	60.6
WP_023437977.1|1151184_1153614_+|tail	phage tail tape measure protein	A0A0A7RU22	Clostridium_phage	5.4e-98	39.2
WP_023437978.1|1153626_1154025_+	hypothetical protein	NA	NA	NA	NA
WP_023437979.1|1154014_1155532_+	hypothetical protein	A0A0A7RU03	Clostridium_phage	9.5e-77	43.1
WP_023437980.1|1155521_1155851_+	hypothetical protein	NA	NA	NA	NA
WP_023437981.1|1155852_1156413_+	hypothetical protein	A0A0A7RW86	Clostridium_phage	1.2e-98	94.6
WP_023437983.1|1157509_1158748_+	hypothetical protein	A0A0A7RU28	Clostridium_phage	7.2e-232	95.1
WP_023437986.1|1160071_1160326_+	hypothetical protein	A0A0A7S0T0	Clostridium_phage	9.7e-43	100.0
WP_023437987.1|1160341_1161340_+	hypothetical protein	A0A0A7RW91	Clostridium_phage	6.0e-189	97.3
WP_023437988.1|1161350_1162433_+	hypothetical protein	A0A0A7RU66	Clostridium_phage	1.8e-199	96.9
WP_023437989.1|1162508_1163300_+	discoidin domain-containing protein	A0A0A7RU33	Clostridium_phage	2.2e-146	96.1
WP_023437990.1|1163356_1164448_+	cell adhesion domain-containing protein	A0A0A7RU14	Clostridium_phage	4.2e-10	53.0
WP_023437991.1|1164498_1164840_+	hypothetical protein	NA	NA	NA	NA
WP_012047659.1|1165571_1165766_+	hypothetical protein	A0A0A7RU02	Clostridium_phage	6.0e-29	100.0
WP_023437993.1|1166333_1166558_+	hemolysin XhlA family protein	A0A0A7RWP8	Clostridium_phage	7.5e-31	89.2
WP_045923674.1|1166575_1166839_+|holin	phage holin family protein	A0A0A7RUX1	Clostridium_phage	1.8e-36	94.3
WP_023437995.1|1166839_1167640_+	glycoside hydrolase family 73 protein	A0A0A7RUD5	Clostridium_phage	1.8e-143	94.7
WP_164968049.1|1167957_1168113_+	hypothetical protein	NA	NA	NA	NA
WP_023437996.1|1168099_1168282_+	hypothetical protein	A0A0A7RTH9	Clostridium_phage	1.2e-23	100.0
WP_023437997.1|1168503_1169373_+	AAA family ATPase	A0A1X9IGI7	Lactococcus_phage	4.4e-34	36.6

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NC_022777|1652559:1659595|DBSCAN-SWA
TTTATTTTTTAAAAATGCTTTTAAATGGGAACTTTTTAATTATAGGTGCTTTATAACTATTTTTTGCTACAAGACTTTCGGTAAATATAAGTTTGTCTTCTTTAAACACATTTATACTTCCAACTTTATCTCCTTCATATATATTGTGATTTATTTCATTTGGCACATTAATTTTTACACTATAGTCGGTTCCTTTTTCTGTTGGAATTATAATGTCTTCTTTGCACACAAGGTCTATATTTTTTTTATCCTTTGGAGCCTTAGCTACAACCTCTCCTTTAGAATGTAATTTTTTATATTCATAATTTTTTTTAACATAATTGTTTACTTTTGTTGTCTCCTTCCATCTTCCAGGACAATCTAAAACTACTATTATTACTTCTCTTCCTGAAATATCTACAGAACTTACAAGACACTTTCCCGCTCCTCCTGTATAACCCGTTTTAACTCCTGTAGCATTTGGAAGTTGCCAAAGTATTTTATTTATATTATGATAATCCCTTGAGAAACTGTATTTATCTTTAGTAATATCCTTTGTACTAACTATCTCATGAAATAATGGATGTTTTTTACTTTCTGCTGTAAGTATAGCCAAGTCATATACTGTTGAGTAATGTTCTGCACTATCTAAACCATGAGGTGAACAAAAATGACTATCTATAAGACCTAAACTTGCTGCATATTCATTCATAAGCCTAACAAATTCTTCTTCACTACCAGCTACTCCTTCCGCTATTGCTATTGCTGCATCATTACCAGATCTAAGCATTAATCCGAATAGAAGCTCCTTTAGTGAGATTTCCTCTCCTTTTTTGTATCCTGCAACAGATCCTCTTATTGAAGACGCTTTAGGAGATATTTCTACCATTTTATCTAAATCACCATATTTTAAAGTTACGAGAGCTGTAAGTATTTTAGTGGTACTAGCCATAGGCATAATAACCTCTGAATTTCTTCCTGCCAAAACTACTTTAGAATTAGCATCCAAAGCTATATAAGCTCTAGCATTCACATTTAATTTATTTTCTTTTTTATTTAAATGTTGATTTGCTAAAACACTATACGTATTTATATTTATAGTTATTATAAAGCATATAAAATATAAAAGTATTTTTTTTATCTTCACCTACAAATCACCTCTTCTTCTTATTATTTTCTATATAAATTTTATTAATCATGAAATTACTTCCATAGGATGTTTGTATATTTTTTTATTATTAGGACATAATTTCTAATATTACATGGAGGATGAATTTTATGTATATAACTCTTATATTACTATTATCTTTAATTATTCTTTTATTTATCCCTATTCCTATAAAAATTTATATAATATATAACGAAAACACATTATCTTTAAAATTAGGTAATAAAGTATTTTCTTTAGATAGATTAAAATTTGAAAATATTAATAAAACTTCTCCCATTGAAAAAATAAGTAAAAAAGAAAATAATCAAAAACTTTCCTTTAAAAGTGTATTGGGGTATTTAAAAATCACTCCTTCAAAGCCTAAATTAAAAATTAGCATATACCTAAACTATGGCTTTGAAGATGCCTATATAACTGCTATTTTCTATGGAATATTCTATTCTATTTATCCCTTTATTTTAGGGCTAATAAACTCATGTTTTACTATAAAAAAAGAAAGGCTTCACATAGAACCTCATTTTAATAAAAATATATTTAATTTTGAAATAAAGAGTATATTTTTCATGAGTATAGCTAAAATTATGTATATATATATTTATTTACTTATAAAGTAAAAAGGAGGTTATAACTCGTGGAAAATCATCCAATAGAAAATTTAATGCAAAGTACAATGGAAAACATAAAAAATATGGTAGATGTAAACACCATTGTAGGCAATACAATACTAACCCCTGATGGAGCTTCCATTATACCTATTTCTAAAGTTTCTTTTGGCTTTGCTTCTGGTGGAAGTGAATATAATTCTTCTATTAGTTCAGATTTAGGCAAATATCCTTTTGGTGGAGGTTCAGGAGCAGGTGTGTCATTAAAACCTGTGGCATTTTTATTTATTAAATCTGATTCTGTAAGACTACTACCTGTAGATCAAACCACTCCTTACGATAGAGTAATAGATACAGTACCGCAACTTGTAGATATGTTTAAAGATATGAGTAAAAGTAAAACTTCTTCAAATAATGCTAATAAATCTTCTACTGTCAATGAATAAATTCCCTCATATTTTAAAATATAGCTTTAGGGAATGTTCTCTAAAGCTATATTTTTTATATAATAAATAAATACGATGTTAAACTTTAGCTTAATGAGCCTTCAGAAGAAAATTAAAATTTTTCAGAGCAAAGCAAGTAAAAATGTCATTAATTGTTCATTATTTAAAGGTCTTCCTCTTGAAATTCTTCTAGAAGTTCTTCTAAACTTGGAAGTTCTTTTATACTTTCCAAGCCAAAATGTTTTAAAAATTCTTCTGTGGTACTATATAATATAGGTCTTCCTGGCACATCTAGCCTACCTGTTTCTTTAATTAAACTTTTTTGCAGTAAGGTTTGTAGTGCTCTATCGCTTTTAACACCTCTGATTTCATCTACATCTACTCTTGTTACAGGTTGCTTATAGGCTACAATGGACAAAGTTTCTAAGGCCGCCTGAGAAATAGATTGACTGCTATTGGTTTTTAAAAGTTGTTCTATAAAGCAGCTGTTTTCTTCCTTTGTAACTAATTGATATTTTTTTTCTATTTCTATTAGTTTTATACCTCTTTTTTCTATTTCATATTCCCTAATCATTTTCTGTAAAATTTCCTTAGTATCTAAAGTATTTAATTCTATTATTTCACTTATGTCTTTTAAACTCAAAGGTTCTCCACTAGCAAATAAAAGTGACTCTATTATTGAGAAAAATCTTAATTCATTCTCTTCATTAATAATATAGTTCATCTGCTTCATCCTCTTTCATCCTCTCTAAGTAAATTTCTTTAAAATTACCTTCTTGAACCACTTTAACTATTTTTATTCTTATTAATTCTAATAGAGCTAAAAAGGTAACTATAACTTCTCCTTTACAACTACATTCTTTACTAATTTTGGAAAAAGAAAGATTTTTATTTTCTATTATTTTGCTTTTTAAATAATCCATTTTGTCCCCTATCTTAAATTCTTCCAACTCTATTTCCTCTGGTATTGTGTTGCTTAGATTTATTTTATCCTTATATTTAGTTATTAGCTCATTATATAAGTTATATAGTTCTAATATGGTTACATCTATAAAAATATCTTTATCCTCTTCCTCTTTTTTTTCAATTATTTCTGGCTTCTTAGAAAATACCGTGAAGCCTTTTTCTAATCTTCCTTTTAAATAATTAGCTACATTTTTAAACTTCTTATATTCTATCAGCTTGTCCAATAATATTTTTTCTGAAGTTTCTTCTGATATTTCCTCCTCTTCTTCATCTTGTGTCTTAGGAAGTAATTCTCTGGACTTTATTTGAAGAAGTGTGGCGGCTATAACTATAAATTCAGAGGTTACTTCTAAATCCATTTCCTTTAAACTTTCTATGTACTCCATATACTGGCCAGTAATTTCTGATATATTTATATTATATATGTCCAATTGATTTTTCTTAATTAAGTGAAGTAATAAATCAAAAGGACCTTGAAAGTTTTGTATTTTAATCTGTAATTCCATATAATCGCTCCTGTATTTTTCTCTTTTAAGTTTTAAAAAATTATATGATAGCCTATTAAAAGACTATCATATTATAAGCTAAACTGCATTATCGAAAATATTTCTAAAATTATGCAGGATATTATCTAATAAACCGGATTTTTTTATGTCTCTATCAGAATATAGTTTAACCTTCCCTATTAATTTATCTCCCACATAAACTTCGCAATGGCCTACTACTTCTCCTTTATTATAGTATTTTTTATCTAAGTTTACTATAGGTTTTTTAGTAATTTTCTCTTTAGAACCTCTTTCTACTACAACATCTAGATCTTCTAGTGCCTTAGCTATAAAAAATTTATCTTCACTTTTACCTAACTTCACCTTTTCTACTTCACTATCTTTTTTTATAATATTTTTATTCTCGAATTTGGACAAACCATAATTCATAAGGTTGGAAGCCTCTTTATTTCTTATTTTATAGTTAGGTGCTCCCATAATTACTGTAAGCACTCTAACTCCATCTCTTACAGCAGTTGCTGATATACAATACTTAGCCTCACTTGTGTAACCTGTTTTTAAGCCATCACAACCTTTAAAAAATCTAACTAATTTATTGTGATTAACTAATCCTATAGGGCTTTTTCTACCTTCTGAAATAGTTTCCATATATGTTCCAGTATATTTTAATATTGTAGGATGTTTTAAAAGTTCTTTGGACATTAAAGCTATATCATAAGCTGTAGTTACATGACCTTCTTCTGGAAGCCCAGAGCAATTTTTAAAATTAGTATTTTTCATACTCAAGGCTTTTGCTCTATCGTTCATAGTTTTTACAAATGCCTCTTCACTTCCCTCTAAGTACTCTGCCATAGCAGTAGCGGCATCATTACCTGAAGCTATAGCTATACCTTTTAATATTTCTTCTACAGTTCTAATTTCTCCTGTATCTAGTAGCATACTACTATTGCCACCTTGACCATTTTTCTTAGCATTTTCACTTACAGTAATTTTATCTGTTAATTTTATTTTCCCCGAATCTACAGCCTCCATAGCAATTAACATAGTCATAATTTTTGTTACAGAAGCTGGTGGTAATTTCTCATTAGCATTTTTTTCATATATTATCTTACCAGAATTAGGTTCCATTAGTAAAGCTGATGATGCTTCTACTTGTATTTCACCTTTATCTTCTCCCTCTGCGCTTACCCTTACTGGTACTACAGTACACTGAAATATAAAAATTAAAAGAATTGTGAATATAAAAGTCTTTTTGTTTTTTATCACGGTTATTCTCTCCTTTCTTCTAAAAATATTTTCCCCCAGCCTTTAAAATTTATCCATTAAAACTAAAAAAATAGATTATCTCATAAAAATAAGATAATCTATTCCCAGTTAACAGTTAGTAGCTAATAGTGAACAATTATGGATAACTTTTCTGCATTTCATTACGACAAATTTTTAATTATATAAAATCCTGATGTTTAGCTTTGCTGGACAAGCTATTCCATAGAGTATAATTAAAATAGCGATGTTTAGCTTTAGCTTAACGAGCCTTCCTAAATAAAATTAAAATTTTTTAGATCAAATCCAAGAAAAATCTCCTTAGTTATTCATTATTCATTGTTAGTTGTTCATTAATTAAATTCTTTCTATTATAGTTCCTACAAGATTTATAAAGGTATTTTTAACCTTGTTTGAAGTTTCTATAACTTCTTTATGATTTAAAGGTTGATCTAGAATTCCCGCTGCCATATTAGTTATACAAGATATACCTAAAACTTTCATATCACAATGTTTTGCTGTTATTGCATCTGGTACTGTAGACATACCTACAGCATCTCCACCTAATATTCTTACCATCTTAACTTCTGCTGGAGTTTCATAAGTTGGTCCTGTCATCATACAGTAAACTCCTTTTTCTATGCCCACATTTATATCCTTTGCAGTGTTTTCTGCTAGTTCCACTAAATCCTTATCATATACATTACTCATATCAGGAAATCTTGATCCTATTTTTTCGTTGTTTTCACCTATTAATGGATTATTGAAAGCTAGATTTATATGATCTGTTATAATCATAAGATCCCCTGGGTTAAAGCTCTCATTCACACCGCCTGCTGCATTTGTTACCAATAAAATCTTTGCTCCTAAGTATTTCATTATGTGAATAGGTAAAGATAAAATCCCCATAGGATGTCCTTCATAATAATGAATTCTTCCTTGCATCATTACTACATTTTTCCCCTTATATTTTCCAAAAACATATTGTCCTTTATGACCACATACTGTTGATTTTGGCATATTAGGTATATCTTCATATTTTACAATTACTTTATCTTGGATTTCTTCAGCTAAATCTCCTAATCCTGAACCTAATATTACTCCTATTTCTGGTACAATATTTATTTTACTTTTTACAAACTCCACACTCTCTAATATTTTTTCTAAATTCATGTTATTTCCTCCTCTGTTATAACTAGTATACTTAAGCTCTAGGATGAGCTTTTTTATAAACCTCAGCTATCTTACTTTTATTAGATATAGTTGAATAGATTTGAGTGGCTGCTAAATCACTATGTCCTAAAAGTTCTTGCACTGATTTCATATCTGCTCCATTTTGCAAAAGATGTACTGCAAAAGAATGTCTTAAAGTATACGAGTTTATAGACTTTTTTATACCTGATATTTTAGCATATTTTTTAACTATTTTCCAAAAACCTTGTCTTGTCATTTGAGTACCTTTTAAATTTAAAAACAGATAATCTAAATTATATATATTAATGTTTGGTCTAATACTTAAATAATCATCTAAACAGTTCACTGCATATGTCCCAATAGGAATAATTCTTTCTTTATTTTTGGATCCTCTGCATTTTATATAGGAAAGTTTTAAACTCACATCAAATACTGTCATATTTAAAAGTTCAGTAACTTTAACCCCTGTAGCATACATAACCTCTAGCATTGCCTTATCTCTTATACCTTTTTCTTCAGAAATATTTGGAGCATTTAATAAAATATCTACCTCTTCTACTGTTAGTACCTTAGGTATGTTTCTTTTAACTTTGGGCAGTTCATAATTTATAACTGGATCCTCATCTATATAACCTTTTTTGTATAAAAATTTATAGAAATTTCTAATAGACACTATATTTCTCACAATTGAGGAGTTAGCTTTTCTACTCTTTTGAAGAGACTGAACATATGCCATTATTGTAACTTCTTCTACATCTAATATATCTTCTTTTCTTTCTTTTAAAAAGTCTAAAAATCTATTTACATCTCTTATATAAGCATCTAAAGTATTTTTGCTTAAGCCTTTGTCCATAAGGCGGCTTATATACTTGTTAATTAGTTCATCTCTAGTTCTTATATTCAATTTCAT

Protein sequences of DBSCAN-SWA_3

>NC_022777|1652559:1659595|1652559_1653684_-|WP_011099736.1|DBSCAN-SWA
MKIKKILLYFICFIITININTYSVLANQHLNKKENKLNVNARAYIALDANSKVVLAGRNSEVIMPMASTTKILTALVTLKYGDLDKMVEISPKASSIRGSVAGYKKGEEISLKELLFGLMLRSGNDAAIAIAEGVAGSEEEFVRLMNEYAASLGLIDSHFCSPHGLDSAEHYSTVYDLAILTAESKKHPLFHEIVSTKDITKDKYSFSRDYHNINKILWQLPNATGVKTGYTGGAGKCLVSSVDISGREVIIVVLDCPGRWKETTKVNNYVKKNYEYKKLHSKGEVVAKAPKDKKNIDLVCKEDIIIPTEKGTDYSVKINVPNEINHNIYEGDKVGSINVFKEDKLIFTESLVAKNSYKAPIIKKFPFKSIFKK
>NC_022777|1652559:1659595|1654339_1654756_+|WP_011099738.1|DBSCAN-SWA
MENHPIENLMQSTMENIKNMVDVNTIVGNTILTPDGASIIPISKVSFGFASGGSEYNSSISSDLGKYPFGGGSGAGVSLKPVAFLFIKSDSVRLLPVDQTTPYDRVIDTVPQLVDMFKDMSKSKTSSNNANKSSTVNE
>NC_022777|1652559:1659595|1658695_1659595_-|WP_023438476.1|DBSCAN-SWA
MKLNIRTRDELINKYISRLMDKGLSKNTLDAYIRDVNRFLDFLKERKEDILDVEEVTIMAYVQSLQKSRKANSSIVRNIVSIRNFYKFLYKKGYIDEDPVINYELPKVKRNIPKVLTVEEVDILLNAPNISEEKGIRDKAMLEVMYATGVKVTELLNMTVFDVSLKLSYIKCRGSKNKERIIPIGTYAVNCLDDYLSIRPNINIYNLDYLFLNLKGTQMTRQGFWKIVKKYAKISGIKKSINSYTLRHSFAVHLLQNGADMKSVQELLGHSDLAATQIYSTISNKSKIAEVYKKAHPRA
>NC_022777|1652559:1659595|1655463_1656228_-|WP_023438472.1|DBSCAN-SWA
MELQIKIQNFQGPFDLLLHLIKKNQLDIYNINISEITGQYMEYIESLKEMDLEVTSEFIVIAATLLQIKSRELLPKTQDEEEEEISEETSEKILLDKLIEYKKFKNVANYLKGRLEKGFTVFSKKPEIIEKKEEEDKDIFIDVTILELYNLYNELITKYKDKINLSNTIPEEIELEEFKIGDKMDYLKSKIIENKNLSFSKISKECSCKGEVIVTFLALLELIRIKIVKVVQEGNFKEIYLERMKEDEADELYY
>NC_022777|1652559:1659595|1657848_1658664_-|WP_023438475.1|DBSCAN-SWA
MNLEKILESVEFVKSKINIVPEIGVILGSGLGDLAEEIQDKVIVKYEDIPNMPKSTVCGHKGQYVFGKYKGKNVVMMQGRIHYYEGHPMGILSLPIHIMKYLGAKILLVTNAAGGVNESFNPGDLMIITDHINLAFNNPLIGENNEKIGSRFPDMSNVYDKDLVELAENTAKDINVGIEKGVYCMMTGPTYETPAEVKMVRILGGDAVGMSTVPDAITAKHCDMKVLGISCITNMAAGILDQPLNHKEVIETSNKVKNTFINLVGTIIERI
>NC_022777|1652559:1659595|1653815_1654322_+|WP_023438470.1|DBSCAN-SWA
MYITLILLLSLIILLFIPIPIKIYIIYNENTLSLKLGNKVFSLDRLKFENINKTSPIEKISKKENNQKLSFKSVLGYLKITPSKPKLKISIYLNYGFEDAYITAIFYGIFYSIYPFILGLINSCFTIKKERLHIEPHFNKNIFNFEIKSIFFMSIAKIMYIYIYLLIK
>NC_022777|1652559:1659595|1654919_1655489_-|WP_045923601.1|DBSCAN-SWA
MKQMNYIINEENELRFFSIIESLLFASGEPLSLKDISEIIELNTLDTKEILQKMIREYEIEKRGIKLIEIEKKYQLVTKEENSCFIEQLLKTNSSQSISQAALETLSIVAYKQPVTRVDVDEIRGVKSDRALQTLLQKSLIKETGRLDVPGRPILYSTTEEFLKHFGLESIKELPSLEELLEEFQEEDL
>NC_022777|1652559:1659595|1656306_1657494_-|WP_023438473.1|DBSCAN-SWA
MIKNKKTFIFTILLIFIFQCTVVPVRVSAEGEDKGEIQVEASSALLMEPNSGKIIYEKNANEKLPPASVTKIMTMLIAMEAVDSGKIKLTDKITVSENAKKNGQGGNSSMLLDTGEIRTVEEILKGIAIASGNDAATAMAEYLEGSEEAFVKTMNDRAKALSMKNTNFKNCSGLPEEGHVTTAYDIALMSKELLKHPTILKYTGTYMETISEGRKSPIGLVNHNKLVRFFKGCDGLKTGYTSEAKYCISATAVRDGVRVLTVIMGAPNYKIRNKEASNLMNYGLSKFENKNIIKKDSEVEKVKLGKSEDKFFIAKALEDLDVVVERGSKEKITKKPIVNLDKKYYNKGEVVGHCEVYVGDKLIGKVKLYSDRDIKKSGLLDNILHNFRNIFDNAV

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011099736.1|1652559_1653684_-	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	1.1e-26	28.6
WP_023438470.1|1653815_1654322_+	DUF2953 domain-containing protein	NA	NA	NA	NA
WP_011099738.1|1654339_1654756_+	sporulation protein YtfJ	NA	NA	NA	NA
WP_045923601.1|1654919_1655489_-	segregation/condensation protein B	A0A1B1IVT7	uncultured_Mediterranean_phage	1.9e-22	35.9
WP_023438472.1|1655463_1656228_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	5.6e-09	27.6
WP_023438473.1|1656306_1657494_-	D-alanyl-D-alanine carboxypeptidase	A0A1P8VVG5	Erythrobacter_phage	7.6e-05	30.4
WP_023438475.1|1657848_1658664_-	purine-nucleoside phosphorylase	Q5YBA4	Grouper_iridovirus	5.7e-60	42.1
WP_023438476.1|1658695_1659595_-	site-specific tyrosine recombinase XerD	A0A1B1IQT7	uncultured_Mediterranean_phage	7.2e-16	27.2