NZ_HG004426_1
684618-686228
Orphan
NA
Consensus_repeat
Method
GTTTGCTAATGACAATGTTTGTGTTGAAAC
PILER-CR
GTTTGCTAATGACAATGTTTGTGTTGAAAC
CRISPRCasFinder
GTTTGCTAATGACAATGTTTGTGTTGAAAC
CRT
24 spacers
>1.1|684648|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
CCGTAAGCTACATTGTAAGCTAAGTCTTCAAAGACT
>1.2|684714|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
TATAAAGGGACCTACGAACTAAGCTAGAACCCTTTT
>1.3|684780|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
GTGTAAGCAAGATGGCAAGAGACTATCTCCTGTTGT
>1.4|684846|35|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
>1.5|684911|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
>1.6|684977|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
>1.7|685043|35|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
>1.8|685108|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
>1.9|685174|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
>1.10|685240|37|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
TCCAGAGCTAATAAGGGATTTAGAGCAGCTAAAAACT
>1.11|685307|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
CGCAAAAAGAGTTGAAATATATAGATAATAGGTTAA
>1.12|685373|35|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
AATCCAACTTAACAAAAATGTTATATAAAATCACC
>1.13|685438|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
TAAACTATTTCGTTATCCTGGTTGATACCGCTTAAA
>1.14|685504|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
ATGAGTTTAAATTTGATAGATCTGAAAAGATTATTC
>1.15|685570|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
CTTGATACTTTTTGCTTGATTAGCTTTGCATTTTTA
>1.16|685636|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
TTTGAAGTGCACGACGCTATAACTAGAACACGGATC
>1.17|685702|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
ATTAAAGCCGAATTACTCCCATTTTTTTTGACTTGG
>1.18|685768|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
TGTATGTTGGTAGCTTTTATGGTTACTTTACATAAC
>1.19|685834|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
TCACCAAAAAAACCAGGAATTAAATAAAAAGTAAAA
>1.20|685900|35|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
AATCCAACTTAACAAAAATGTTATATAAAATCACC
>1.21|685965|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
TAAGCAAGGCTTATAAGCTCTTTACAATGCATTTTT
>1.22|686031|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
AGAACTGTTTTAACCTCACTTCCATCAATCTCTTTT
>1.23|686097|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
CAGTATGCCATTTGATTCTAGTTCGCCTATAGCTCT
>1.24|686163|36|NZ_HG004426|PILER-CR,CRISPRCasFinder,CRT
CATCCTCCTTTTAATTTATTACATTTAAACAATTTA
Detail
CRISPR arrays
Neighbor Proteins Overview
HMMScan for Signature genes
rpsblast for functional proteins
Protein sequences
The CRISPR arrays of NZ_HG004426_1
>merge|NZ_HG004426|1|684618-686228|PILER-CR,CRISPRCasFinder,CRT
GTTTGCTAATGACAATGTTTGTGTTGAAACCCGTAAGCTACATTGTAAGCTAAGTCTTCAAAGACTGTTTGCTAATGACAATGTTTGTGTTGAAACTATAAAGGGACCTACGAACTAAGCTAGAACCCTTTTGTTTGCTAATGACAATGTTTGTGTTGAAACGTGTAAGCAAGATGGCAAGAGACTATCTCCTGTTGTGTTTGCTAATGACAATGTTTGTGTTGAAACCGGGGAGCAACGTTAGCAATCTCATTTCCGTCCATGTTTGCTAATGACAATGTTTGTGTTGAAACTGGGGATTCGATGAAATTTTTAACTATATAGCATTCGTTTGCTAATGACAATGTTTGTGTTGAAACTTTTTATAAGGCTCATTTTTGAAGATATTATGCTGCGTTTGCTAATGACAATGTTTGTGTTGAAACCGGGGAGCAACGTTAGCAATCTCATTTCCGTCCATGTTTGCTAATGACAATGTTTGTGTTGAAACTGGGGATTCGATGAAATTTTTAACTATATAGCATTCGTTTGCTAATGACAATGTTTGTGTTGAAACTTTTTATAAGGCTCATTTTTGAAGATATTATGCTGCGTTTGCTAATGACAATGTTTGTGTTGAAACTCCAGAGCTAATAAGGGATTTAGAGCAGCTAAAAACTGTTTGCTAATGACAATGTTTGTGTTGAAACCGCAAAAAGAGTTGAAATATATAGATAATAGGTTAAGTTTGCTAATGACAATGTTTGTGTTGAAACAATCCAACTTAACAAAAATGTTATATAAAATCACCGTTTGCTAATGACAATGTTTGTGTTGAAACTAAACTATTTCGTTATCCTGGTTGATACCGCTTAAAGTTTGCTAATGACAATGTTTGTGTTGAAACATGAGTTTAAATTTGATAGATCTGAAAAGATTATTCGTTTGCTAATGACAATGTTTGTGTTGAAACCTTGATACTTTTTGCTTGATTAGCTTTGCATTTTTAGTTTGCTAATGACAATGTTTGTGTTGAAACTTTGAAGTGCACGACGCTATAACTAGAACACGGATCGTTTGCTAATGACAATGTTTGTGTTGAAACATTAAAGCCGAATTACTCCCATTTTTTTTGACTTGGGTTTGCTAATGACAATGTTTGTGTTGAAACTGTATGTTGGTAGCTTTTATGGTTACTTTACATAACGTTTGCTAATGACAATGTTTGTGTTGAAACTCACCAAAAAAACCAGGAATTAAATAAAAAGTAAAAGTTTGCTAATGACAATGTTTGTGTTGAAACAATCCAACTTAACAAAAATGTTATATAAAATCACCGTTTGCTAATGACAATGTTTGTGTTGAAACTAAGCAAGGCTTATAAGCTCTTTACAATGCATTTTTGTTTGCTAATGACAATGTTTGTGTTGAAACAGAACTGTTTTAACCTCACTTCCATCAATCTCTTTTGTTTGCTAATGACAATGTTTGTGTTTAAACCAGTATGCCATTTGATTCTAGTTCGCCTATAGCTCTGTTTGCTAATGACAATGTTTGTGTTGAAACCATCCTCCTTTTAATTTATTACATTTAAACAATTTAGTTTGCTAATGACAATGTTTGTGTTGAAAC
>NZ_HG004426|1|1|684618-686228|PILER-CR
GTTTGCTAATGACAATGTTTGTGTTGAAAC CCGTAAGCTACATTGTAAGCTAAGTCTTCAAAGACT
GTTTGCTAATGACAATGTTTGTGTTGAAAC TATAAAGGGACCTACGAACTAAGCTAGAACCCTTTT
GTTTGCTAATGACAATGTTTGTGTTGAAAC GTGTAAGCAAGATGGCAAGAGACTATCTCCTGTTGT
GTTTGCTAATGACAATGTTTGTGTTGAAAC CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
GTTTGCTAATGACAATGTTTGTGTTGAAAC TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
GTTTGCTAATGACAATGTTTGTGTTGAAAC CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
GTTTGCTAATGACAATGTTTGTGTTGAAAC TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TCCAGAGCTAATAAGGGATTTAGAGCAGCTAAAAACT
GTTTGCTAATGACAATGTTTGTGTTGAAAC CGCAAAAAGAGTTGAAATATATAGATAATAGGTTAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC AATCCAACTTAACAAAAATGTTATATAAAATCACC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TAAACTATTTCGTTATCCTGGTTGATACCGCTTAAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC ATGAGTTTAAATTTGATAGATCTGAAAAGATTATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC CTTGATACTTTTTGCTTGATTAGCTTTGCATTTTTA
GTTTGCTAATGACAATGTTTGTGTTGAAAC TTTGAAGTGCACGACGCTATAACTAGAACACGGATC
GTTTGCTAATGACAATGTTTGTGTTGAAAC ATTAAAGCCGAATTACTCCCATTTTTTTTGACTTGG
GTTTGCTAATGACAATGTTTGTGTTGAAAC TGTATGTTGGTAGCTTTTATGGTTACTTTACATAAC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TCACCAAAAAAACCAGGAATTAAATAAAAAGTAAAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC AATCCAACTTAACAAAAATGTTATATAAAATCACC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TAAGCAAGGCTTATAAGCTCTTTACAATGCATTTTT
GTTTGCTAATGACAATGTTTGTGTTGAAAC AGAACTGTTTTAACCTCACTTCCATCAATCTCTTTT
GTTTGCTAATGACAATGTTTGTGTTTAAAC CAGTATGCCATTTGATTCTAGTTCGCCTATAGCTCT
GTTTGCTAATGACAATGTTTGTGTTGAAAC CATCCTCCTTTTAATTTATTACATTTAAACAATTTA
GTTTGCTAATGACAATGTTTGTGTTGAAAC
>NZ_HG004426|1|1|684618-686228|CRISPRCasFinder
GTTTGCTAATGACAATGTTTGTGTTGAAAC CCGTAAGCTACATTGTAAGCTAAGTCTTCAAAGACT
GTTTGCTAATGACAATGTTTGTGTTGAAAC TATAAAGGGACCTACGAACTAAGCTAGAACCCTTTT
GTTTGCTAATGACAATGTTTGTGTTGAAAC GTGTAAGCAAGATGGCAAGAGACTATCTCCTGTTGT
GTTTGCTAATGACAATGTTTGTGTTGAAAC CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
GTTTGCTAATGACAATGTTTGTGTTGAAAC TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
GTTTGCTAATGACAATGTTTGTGTTGAAAC CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
GTTTGCTAATGACAATGTTTGTGTTGAAAC TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TCCAGAGCTAATAAGGGATTTAGAGCAGCTAAAAACT
GTTTGCTAATGACAATGTTTGTGTTGAAAC CGCAAAAAGAGTTGAAATATATAGATAATAGGTTAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC AATCCAACTTAACAAAAATGTTATATAAAATCACC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TAAACTATTTCGTTATCCTGGTTGATACCGCTTAAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC ATGAGTTTAAATTTGATAGATCTGAAAAGATTATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC CTTGATACTTTTTGCTTGATTAGCTTTGCATTTTTA
GTTTGCTAATGACAATGTTTGTGTTGAAAC TTTGAAGTGCACGACGCTATAACTAGAACACGGATC
GTTTGCTAATGACAATGTTTGTGTTGAAAC ATTAAAGCCGAATTACTCCCATTTTTTTTGACTTGG
GTTTGCTAATGACAATGTTTGTGTTGAAAC TGTATGTTGGTAGCTTTTATGGTTACTTTACATAAC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TCACCAAAAAAACCAGGAATTAAATAAAAAGTAAAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC AATCCAACTTAACAAAAATGTTATATAAAATCACC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TAAGCAAGGCTTATAAGCTCTTTACAATGCATTTTT
GTTTGCTAATGACAATGTTTGTGTTGAAAC AGAACTGTTTTAACCTCACTTCCATCAATCTCTTTT
GTTTGCTAATGACAATGTTTGTGTTTAAAC CAGTATGCCATTTGATTCTAGTTCGCCTATAGCTCT
GTTTGCTAATGACAATGTTTGTGTTGAAAC CATCCTCCTTTTAATTTATTACATTTAAACAATTTA
GTTTGCTAATGACAATGTTTGTGTTGAAAC
>NZ_HG004426|1|1|684618-686228|CRT
GTTTGCTAATGACAATGTTTGTGTTGAAAC CCGTAAGCTACATTGTAAGCTAAGTCTTCAAAGACT
GTTTGCTAATGACAATGTTTGTGTTGAAAC TATAAAGGGACCTACGAACTAAGCTAGAACCCTTTT
GTTTGCTAATGACAATGTTTGTGTTGAAAC GTGTAAGCAAGATGGCAAGAGACTATCTCCTGTTGT
GTTTGCTAATGACAATGTTTGTGTTGAAAC CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
GTTTGCTAATGACAATGTTTGTGTTGAAAC TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
GTTTGCTAATGACAATGTTTGTGTTGAAAC CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
GTTTGCTAATGACAATGTTTGTGTTGAAAC TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TCCAGAGCTAATAAGGGATTTAGAGCAGCTAAAAACT
GTTTGCTAATGACAATGTTTGTGTTGAAAC CGCAAAAAGAGTTGAAATATATAGATAATAGGTTAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC AATCCAACTTAACAAAAATGTTATATAAAATCACC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TAAACTATTTCGTTATCCTGGTTGATACCGCTTAAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC ATGAGTTTAAATTTGATAGATCTGAAAAGATTATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC CTTGATACTTTTTGCTTGATTAGCTTTGCATTTTTA
GTTTGCTAATGACAATGTTTGTGTTGAAAC TTTGAAGTGCACGACGCTATAACTAGAACACGGATC
GTTTGCTAATGACAATGTTTGTGTTGAAAC ATTAAAGCCGAATTACTCCCATTTTTTTTGACTTGG
GTTTGCTAATGACAATGTTTGTGTTGAAAC TGTATGTTGGTAGCTTTTATGGTTACTTTACATAAC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TCACCAAAAAAACCAGGAATTAAATAAAAAGTAAAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC AATCCAACTTAACAAAAATGTTATATAAAATCACC
GTTTGCTAATGACAATGTTTGTGTTGAAAC TAAGCAAGGCTTATAAGCTCTTTACAATGCATTTTT
GTTTGCTAATGACAATGTTTGTGTTGAAAC AGAACTGTTTTAACCTCACTTCCATCAATCTCTTTT
GTTTGCTAATGACAATGTTTGTGTTTAAAC CAGTATGCCATTTGATTCTAGTTCGCCTATAGCTCT
GTTTGCTAATGACAATGTTTGTGTTGAAAC CATCCTCCTTTTAATTTATTACATTTAAACAATTTA
GTTTGCTAATGACAATGTTTGTGTTGAAAC
Protein
Signature genes
Signature genes Name
Protein_function
NZ_HG004426.1|WP_002849076.1|690288_690525_+|hypothetical-protein
unknown
unknown
unknown
NZ_HG004426.1|WP_002849044.1|676836_677790_+|NAD(P)-binding-domain-containing-protein
unknown
unknown
gnl|CDD|379355
NZ_HG004426.1|WP_002849046.1|680407_680779_+|YkgJ-family-cysteine-cluster-protein
unknown
unknown
gnl|CDD|223799
NZ_HG004426.1|WP_010403934.1|679718_680414_+|methyltransferase
unknown
unknown
gnl|CDD|226608
NZ_HG004426.1|WP_046037358.1|693981_695463_+|inorganic-phosphate-transporter
unknown
unknown
gnl|CDD|223383
NZ_HG004426.1|WP_002849081.1|692923_693847_+|4-hydroxythreonine-4-phosphate-dehydrogenase
unknown
unknown
gnl|CDD|179681
NZ_HG004426.1|WP_011731910.1|691284_692109_+|adenylosuccinate-lyase
unknown
unknown
gnl|CDD|236352
NZ_HG004426.1|WP_024305373.1|680754_682050_+|hypothetical-protein
unknown
unknown
gnl|CDD|274350
NZ_HG004426.1|WP_011731891.1|683325_684063_+|YaaA-family-protein
unknown
unknown
gnl|CDD|377151
NZ_HG004426.1|WP_002849060.1|687339_687546_+|hypothetical-protein
unknown
unknown
unknown
NZ_HG004426.1|WP_002849052.1|682822_683329_+|HIT-domain-containing-protein
unknown
unknown
gnl|CDD|238606
NZ_HG004426.1|WP_002849077.1|690511_691228_+|arginyltransferase
unknown
unknown
gnl|CDD|234939
NZ_HG004426.1|WP_002849039.1|674029_675373_+|3-deoxy-7-phosphoheptulonate-synthase-class-II
unknown
unknown
gnl|CDD|366662
NZ_HG004426.1|WP_025370330.1|686238_687006_+|hypothetical-protein
unknown
unknown
gnl|CDD|213641
NZ_HG004426.1|WP_011731911.1|692153_692927_+|pyridoxine-5'-phosphate-synthase
unknown
unknown
gnl|CDD|235380
NZ_HG004426.1|WP_002849067.1|686981_687299_+|hypothetical-protein
unknown
unknown
unknown
NZ_HG004426.1|WP_002849074.1|688836_690282_+|acetyl-CoA-carboxylase-subunit-A
unknown
unknown
gnl|CDD|169452
NZ_HG004426.1|WP_002849050.1|682046_682823_+|indole-3-glycerol-phosphate-synthase-TrpC
unknown
unknown
gnl|CDD|234710
NZ_HG004426.1|WP_024305374.1|677799_679722_+|hypothetical-protein
unknown
unknown
gnl|CDD|274008
NZ_HG004426.1|WP_002849042.1|675534_676758_-|glutamate-5-semialdehyde-dehydrogenase
unknown
unknown
gnl|CDD|143398
Protein
Cas_name
Cas_description
E-value
Identity
Coverage
Protein
Function_ID
Function_description
E-value
NZ_HG004426.1|WP_002849044.1|676836_677790_+|NAD(P)-binding-domain-containing-protein
gnl|CDD|379355
pfam13738, Pyr_redox_3, Pyridine nucleotide-disulphide oxidoreductase.
1.83609e-57
NZ_HG004426.1|WP_002849046.1|680407_680779_+|YkgJ-family-cysteine-cluster-protein
gnl|CDD|223799
COG0727, COG0727, Predicted Fe-S-cluster oxidoreductase [General function prediction only].
1.65843e-13
NZ_HG004426.1|WP_010403934.1|679718_680414_+|methyltransferase
gnl|CDD|226608
COG4123, COG4123, Predicted O-methyltransferase [General function prediction only].
5.72991e-53
NZ_HG004426.1|WP_002849081.1|692923_693847_+|4-hydroxythreonine-4-phosphate-dehydrogenase
gnl|CDD|179681
PRK03946, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional.
0
NZ_HG004426.1|WP_011731910.1|691284_692109_+|adenylosuccinate-lyase
gnl|CDD|236352
PRK08937, PRK08937, adenylosuccinate lyase; Provisional.
2.29446e-18
NZ_HG004426.1|WP_024305373.1|680754_682050_+|hypothetical-protein
gnl|CDD|274350
TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.
9.35572e-08
NZ_HG004426.1|WP_011731891.1|683325_684063_+|YaaA-family-protein
gnl|CDD|377151
pfam03883, H2O2_YaaD, Peroxide stress protein YaaA. YaaA is a key element of the stress response to H2O2. It acts by reducing the level of intracellular iron levels after peroxide stress, thereby attenuating the Fenton reaction and the DNA damage that this would cause. The molecular mechanism of action is not known.
3.02596e-45
NZ_HG004426.1|WP_002849052.1|682822_683329_+|HIT-domain-containing-protein
gnl|CDD|238606
cd01275, FHIT, FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.
3.923e-47
NZ_HG004426.1|WP_002849077.1|690511_691228_+|arginyltransferase
gnl|CDD|234939
PRK01305, PRK01305, arginyl-tRNA-protein transferase; Provisional.
7.00248e-89
NZ_HG004426.1|WP_002849039.1|674029_675373_+|3-deoxy-7-phosphoheptulonate-synthase-class-II
gnl|CDD|366662
pfam01474, DAHP_synth_2, Class-II DAHP synthetase family. Members of this family are aldolase enzymes that catalyze the first step of the shikimate pathway.
0
NZ_HG004426.1|WP_025370330.1|686238_687006_+|hypothetical-protein
gnl|CDD|213641
TIGR01641, Uncharacterized_protein_MJ0329, phage putative head morphogenesis protein, SPP1 gp7 family. This model describes a region of about 110 amino acids found exclusively in phage-related proteins, internally or toward the C-terminus. One member, gp7 of phage SPP1, appears involved in head morphogenesis. [Mobile and extrachromosomal element functions, Prophage functions].
0.000442902
NZ_HG004426.1|WP_011731911.1|692153_692927_+|pyridoxine-5'-phosphate-synthase
gnl|CDD|235380
PRK05265, PRK05265, pyridoxine 5'-phosphate synthase; Provisional.
9.13382e-114
NZ_HG004426.1|WP_046037358.1|693981_695463_+|inorganic-phosphate-transporter
gnl|CDD|223383
COG0306, PitA, Phosphate/sulphate permeases [Inorganic ion transport and metabolism].
1.16118e-49
NZ_HG004426.1|WP_002849074.1|688836_690282_+|acetyl-CoA-carboxylase-subunit-A
gnl|CDD|169452
PRK08463, PRK08463, acetyl-CoA carboxylase subunit A; Validated.
0
NZ_HG004426.1|WP_002849050.1|682046_682823_+|indole-3-glycerol-phosphate-synthase-TrpC
gnl|CDD|234710
PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.
6.08927e-122
NZ_HG004426.1|WP_024305374.1|677799_679722_+|hypothetical-protein
gnl|CDD|274008
TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].
9.18393e-08
NZ_HG004426.1|WP_002849042.1|675534_676758_-|glutamate-5-semialdehyde-dehydrogenase
gnl|CDD|143398
cd07079, ALDH_F18-19_ProA-GPR, Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19. Gamma-glutamyl phosphate reductase (GPR), a L-proline biosynthetic pathway (PBP) enzyme that catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The glutamate route of the PBP involves two enzymatic steps catalyzed by gamma-glutamyl kinase (GK, EC 2.7.2.11) and GPR (EC 1.2.1.41). These enzymes are fused into the bifunctional enzyme, ProA or delta(1)-pyrroline-5-carboxylate synthetase (P5CS) in plants and animals, whereas they are separate enzymes in bacteria and yeast. In humans, the P5CS (ALDH18A1), an inner mitochondrial membrane enzyme, is essential to the de novo synthesis of the amino acids proline and arginine. Tomato (Lycopersicon esculentum) has both the prokaryotic-like polycistronic operons encoding GK and GPR (PRO1, ALDH19) and the full-length, bifunctional P5CS (PRO2, ALDH18B1).
0
>NZ_HG004426.1|WP_011731891.1|683325_684063_+|YaaA-family-protein
MKILFSPSESKMSGGSRDASVNFSWVFPNLNDKRLEILEMYNSFLKKANKNELQALFGLKKDNELEYYSSDLFSRPLMKAILRYNGVAYEHLNYRNLDERSRKMIDENTIIFSNLYGVILAKDMIFDYKLKQGESIGGFRTEVFYKKYFSGVLDDFLDSDILDLRAGFYEKFYSLTKPYTTIKFLKNGKVVSHFAKAYRGIVLRCIALNQISSLDEFYNMQIPNLKINKIIKNRLKTEIVVDIIG
>NZ_HG004426.1|WP_002849052.1|682822_683329_+|HIT-domain-containing-protein
MEHEFSPWRAEYFKTRKDDGVTDHSCVFCDIAENIQNDEENFVLFRAKNCFAVMNRYPYTLGEFMIIPYIHTDNIENLDKNIWSEMSDLVQLGVGVLKESLNANGVNIGMNLGSAAGAGIAEHIHYHLVPRWSRDTNFITTIAYTRVHGVPFLDQYHTLKKAFQKIFK
>NZ_HG004426.1|WP_002849050.1|682046_682823_+|indole-3-glycerol-phosphate-synthase-TrpC
MILDEIISKTKINLENIKENLPLCRLENALTNSYIPRDVKQVLKQKNSINIIAEIKKASPSKGVIKEDFDPLKIAFEYEKAGVSAFSILTEPFYFQGSLEYIALVRRYTNTPILRKDFIVDIYQIAEARLYGADFILLIAKALDKFYLKTLFEYAKSLNLEVLMEIHDETDLEKALFVDADIIGINHRNLQTFDMDMELCIKLIPLIPSGKIIVAESGLYNNSELINLKKQGADAFLIGEHFMRQESIYNAVKDMKGE
>NZ_HG004426.1|WP_024305373.1|680754_682050_+|hypothetical-protein
MYWCRAALIFTLFLAGCADKQSVGAKKNETFFKYSDINTTIDLEAMKGFYLLGDAKSKDALEVFYMLYKTTKKPIFLKEALKIAFVIKDDRLDELITDAREILNADYDVIRIEIGYYILKSQIKDAKDLALNLIQKESDNSINHSILATIYLFNDEPIRALKEFKKAYEIEGSEENLLKLVDMLDNKLDRTNEAIRYLNNWIGENGCSKPVCFTLLNIYSAKGELDLMIEVYIKLYEAYEESDFLNRALEILLYKKDVISAKELLEKYSFNEPILMEIYAELKEFQKAYNVAQDLYNRSQNPEYMARMAIYKYEQSSKNISKFELDMVVKLFEGSVYALNSPIYFNYYGYLLIDYEIDLKKGLDIAKKAYILDPNSPYIIDSIAWGYFKLGECKEAKMWMDKIQSDTKFMKEDEAKAHKTAIDKCFNKGTK
>NZ_HG004426.1|WP_002849046.1|680407_680779_+|YkgJ-family-cysteine-cluster-protein
MLKEFGFDYCFDSSKCEVCGAKCCTGDSGYIWISEAEMESLSSHLKLSLPEFKKLFTYRVGVRFSLKEKEYNGAYACLFFDENNKNCSVYEFRPKQCRTFPFWDYFKKHFNELEKECIGVERL
>NZ_HG004426.1|WP_010403934.1|679718_680414_+|methyltransferase
MKLFQLKEGYRYNSDTLFLYDFISKNQIFGNVLDVGCGCGILGLLLKRDFINLNLSSIDIQEINSTITQLNADVNNLVAAVICDDFSKFKSEIKFDFIVSNPPFYNSQITKSENEHISISRYSSSLDPLSFFKSVNANLKPQGVLYFCYDARRVGEILPILSSLKLKLTKLRFVHSRISESSKLALFEAKKSSKSICGIYPPLIIFDENEFSGEVKEIFKKSDTKSEIYEC
>NZ_HG004426.1|WP_024305374.1|677799_679722_+|hypothetical-protein
MKFRKFAQILFLVGTIFFILGCETKDEKALNQDKLKFSDLSMAEQDRYISKDELDKLGSYLTLLNNRNIDINSDEIPSGSVDELRDKIAELIQKNRLLFADNEELAKKNLEIITKLREQNSLRESENKLISAKYLDSMNEVEKQHYKNINDLTKKINEVQKENIQSIKSYEQKIIGLENKIDELEKELSKKDINFNEKVSSATKDQLEKNKELSQKNSYLLEQTQVLKKQVDTLSKELDSKLADKKTQIDTLNQTILTKDNKINDLLASHTNEIIELQNKHSKALYDIKNELDRQKNDYFGELNLKNSELAKLNNDFKEYKLKKDEELKNAENRVLINYKKIETQRLNAIKSDYERIIFEQNRTIAAFEGKMINLELKFKKDLEAKDANYVNTLENLKQKALFLKNDEDRLRAEFDKNITSLKSQITLKNIQISELDSKIKELENEKNDIKKIQNYEILNNMITKLNAQNEELKNYAKKALDEAKKMVLEAENKAKEQNDKLKNYYEELIKNIKNQDNQPVLSDINVDSKRFLSEISCLSLDKSAKLDKDCENKLNDMIKKYGKSRIYEIKAVISDFKFLGDDKVGELKNVNLLNLKSTKDMLNAASKAINSKIKDPMLAYSKDVLLEQSGYGFVIKVYE
>NZ_HG004426.1|WP_002849044.1|676836_677790_+|NAD(P)-binding-domain-containing-protein
MENIYDVVVIGGGPFGIATVVEAKYNGFKNVLLLEKGDNHSQTIRKFYKDGKRVDKVYKGLDSQTHGNVEFFDGTKESTLNYFDNLLDNGKIDAVFNIEVESVKKDGDIFNIVTSKNTYKSKNVMIGIGRMGKPNKPEYKIPPSLTQIVNFNLNSCNCGENILVIGGGNSAAEYAIELSKCNTVTLCYRKEKFTRLNEINEAQVFEYFNDKKLNLKLGIDVIGLDNENGKVKVNFSNNSSEIYDRIIYAIGGSTPVDFLQKCGIELNKDGEPIVDEHLQTNTPRLFVGGDIASKNGGSIVVALNDAHTVIDYIIKSK
>NZ_HG004426.1|WP_002849042.1|675534_676758_-|glutamate-5-semialdehyde-dehydrogenase
MEKLLNNLKNSSKSLSILTQTQRENLIINIANEIMSAKDEILSANKIDLDLAQDLSSALKDRLKLTSKSIENLCNSIKNIANLKDVIGVIKDGWQTKSGLKIEKITIPLGNIATIYESRPNVTAEVAALCIKSANGCALKGGKEAKNTNLAIIKAIHKALQKCGLDKNCVVYLDIDRNEVKKLINMDKYLDLIVPRGGENLVKFVSQNATIPVLKHDKGLCHIYVDEFADLDKALSICVNAKCSRPGVCNAAETILVHEEVANEFIPNLKKSLDEFNVIIFGCKKTAKIIDCELANEQNYSTEYLDFKLNLKIVKNLEESLEHISEFSSGHSEAVISESYSICERFLSLVDSACVYANASTRFSDGGEFGFGAEIGISTNKLHARGPVGLNELTTYKYIIRANGQIR
>NZ_HG004426.1|WP_002849039.1|674029_675373_+|3-deoxy-7-phosphoheptulonate-synthase-class-II
MSKWNRDSWRDYNILQQPHYPDKNELKNAEDKLKSLPPLVFAGEVRNLKDELKNVTLGKSFLLQGGDCAESFSNFSANGIRDMFKIMLQMAIVLTFAGGCPVVKVGRVAGQFAKPRSSDFEDIDGVKLPSYRGDIINGFDFTEEARIPDPKRMIDAYYQSASTLNLLRAFSRGGLANLNEVHRWNLGFIKKAELDNKFEKLADELTGALKFMEACGVTTQNTPTLSETKLYTSHEALLLPYEEALTRVDSLTNEWYDCSAHMLWIGERTRGINDAHVHFLSGIKNPIGCKIGPDGKPGDIISLAGKLNPDNEPGRLNIIIRMGADKIEDRLPAILNYVKKEGLNILWSIDPMHGNTIKASSGFKTREFNNVMREVKSFFEIHRACGTIAGGVHLEMTGQDVTECVGGAFNVTEDSLGNRYETQCDPRLNADQALELAFLIADLVKKR
>NZ_HG004426.1|WP_025370330.1|686238_687006_+|hypothetical-protein
MAETLKEKFKGVLSANTSYFEGVSDHIISQAQNIARVNQSSKYGVKHYKVLARIDSRTSDICRSMNGRIIPASHIEAQSNNIQNAKDINEKKAAAIWRNEPFLGKILPSNFGLPPYHFRCRTELVPVWINEEEIDGVKMKNTSPLSKDEVVKHIDKTGVERYANKKTFNHSISSNKRKISSSDSVKALNSILKIAPHKDYQNRSVAISQNGYFMIFNGDYLYNIFKPSRNLEKYFKDSAVLNKVEIIKWKFSIFA
>NZ_HG004426.1|WP_002849067.1|686981_687299_+|hypothetical-protein
MEIFNICLAHGWAIESVKNGNFGENAKYDLFAQFDVFYGQIAWIYDICTPSDETIKECEKIAIFKQMCEFNVYISDDNDEGWTKKVNFTGTFIDALEYIKANFGK
>NZ_HG004426.1|WP_002849060.1|687339_687546_+|hypothetical-protein
MTIIEAFNKTKTLQNQNRNAVVKIVKKNYSGYDVQIEPVELTVIKNSLEMISQNANSFMANVNAKYGK
>NZ_HG004426.1|WP_002849074.1|688836_690282_+|acetyl-CoA-carboxylase-subunit-A
MIHKILIANRGEIAVRIVRACKDLHIKNVAIYTEPDRECLHVKVADEAYQIGKDPIKGYLDSKRIVEVAKACGADAIHPGYGFLSENYEFSKEVEDAGLIFIGPNSDIIRKMGNKNIARFLMKKNGIPVVPGTEKLNSETIEAIKNYAVRIGYPVILKASGGGGGRGIRVVWKEDELESSYESCKREAKAFFNNDEVFMEKYIEKPRHIEFQILGDNYGNLIHLCERDCSIQRRHQKVIEIAPCPTISEDLRKRMGVAAVAAAKAVGYTNAGTIEFLLDDYNNFYFMEMNTRIQVEHGVTEEITGVDLISRQIRIAAGEILDIEQNEVRPQGVSIEARITAENVWKNFAPSPGRITGYFPALGPGVRVDSHMYQDYVIPPFYDSLVAKLIVKGTSYDLAVSKLERALDEFKIEGVRTTLPFLLAISKRRHFRRGFFDTSYIEERLQDILENTQDHHQENKEEVIAAIAAAIKKVKEDRAKE
>NZ_HG004426.1|WP_002849076.1|690288_690525_+|hypothetical-protein
MNDFFDSLKNIKNELVKEQKSQEIKVPKKPKPNPNRDEFKDIFAEPNEIEMPDAKEHRLKDEFLEFIKHSDVKKLERD
>NZ_HG004426.1|WP_002849077.1|690511_691228_+|arginyltransferase
MREIDFCTLDTLCPYLEDRNSRTMYRYVSQCSFDYNSNLVKHGYRRFGSYFSKPICDGCDECKSIRIDAFNFKFTKSHRRIINKNSNTKIVVSKPYISQRHIDLYEKYHKFMHEKRGWEYYNLDFRRYYSVYVEGAGDFGYEIDYFVNDELVCVDLVDIVDDGISSIYCYWDIDFAHLSLGKFSLLNQITIALKNDLRWIYLGFYVKDCASLAYKGEYKPYETLKTYCDIDEKPIWEF
>NZ_HG004426.1|WP_011731910.1|691284_692109_+|adenylosuccinate-lyase
MQITQTLESITITTDDCDLFLNLSNKIRQSFANAIGNRDKVIIFYNENELVQRKYFLKLIGKIYANSVGKGIDFLLTHHKNIKLVYKKPNSLQILINVDVKFENSRVVLDLKNSEELFTKYLIRGLGDTRHEYFESKNILVISPKTTEDVELLDNILNFREHLKYIVNFNYDKKAYDEFKKRAKILTSKAYIRRFSMLANLLEEHFETLGCKATDDFETVRTNYLNLTKVYHPDKHAGKPNEVQKSYIDKFQKIGLAYEALKPYFKEQKSFISA
>NZ_HG004426.1|WP_011731911.1|692153_692927_+|pyridoxine-5'-phosphate-synthase
MKLGVNIDHVAVLREARAVNDPQIIHAMFEAVSGGADQITIHLREDRRHINEDDVKNIINLSPIPVNLECSINSEIIDIVCELKPHRATIVPEKREELTTEGGLSLDSLNLKNVISKLNDNDIKVSLFINPKKNDVIMSKELGATCVELHTGAYANTFLMLNSNLNHTKYKIDNLNLKRGELEILLNSELTRIKEAANISTNLGLEVAAGHGLNYQNVTAISSIKDIFELNIGQSIVAKSVFVGLKNAVKEMMELVK
>NZ_HG004426.1|WP_002849081.1|692923_693847_+|4-hydroxythreonine-4-phosphate-dehydrogenase
MSLPKIAISVGDINGVGIEIALKSHDEIKNICSPIYFINNELLNSAANILKFTVPNDFEIFECGSSFNIKPGRVSKKSGKFSFVSFENAILYTQNKRAQALVTMPINKESWKKAGVPYVGHTDALGKYFGKNAIMMLGCEELFVALYTDHLALKDVSAKIKAKNLALFLVDFYNSSKFENIGVLGFNPHASDNETIGGKEEKEIIKAIKSANNRLKKEVFTGPLVSDAAFTKSSLKRCNRLVSMYHDVGLAPLKALYFDKSINVSLNLPIVRTSVDHGTAFDIAYKGKAETKSYIEAIKFAIKLCDY
>NZ_HG004426.1|WP_046037358.1|693981_695463_+|inorganic-phosphate-transporter
MWGYNYIPSNHLLLFILASIFGLFMAFNIGGNDVANSFGTSVGAKTLTLKQALIIAAVFELSGAVFAGAEVTNTIRSGIVSLPRGDVNPMVFVIIMISALFSSGAWLFIATKKGLPVSTTHSIVGGIVGAGMMMGFIYYNGSKTFDMVQWGEIGRIALSWVISPVMGGVMAYLIFGYIKSKIIIPSSRIQSEIKSLKRARKTYKDQYIKELSNKSEAEQIKELRRIAIIDEDECEGENCDFRDKIKAMKEQEKNIDGMVFMRTHIPMVAGVAAMIIAGSMLFKGLKHMDFNLSIIQTIWIIFVIGIAAYLASFAIVNLMKKDNPQKGINRIFGWFQIFTASSFAFSHGANDIANAVGPFAAILDVLKNNTINETTPIPGIAMATFGIALVVGLWFLGKEVIATVGTKLAEILPTTGFSAELAASIVILIATKMGLPISSTHVLIGAVLGIGVYNRNANWGMLKPIGLAWIITLPISMIGSAIGFLVIKNIMGL