CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP011410	Leptospira interrogans serovar Bratislava strain PigK151 chromosome I, complete sequence	11 crisprs	WYL,csa3,cas3,cas5,cas7,cas8b3,cas6,cas2,cas1,DinG,cas8c,cas4,Cas9_archaeal	3	1	3	0
NZ_CP011411	Leptospira interrogans serovar Bratislava strain PigK151 chromosome II, complete sequence	0 crisprs	csa3	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP011410_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011410_1

1201469-1201563

Orphan

Consensus_repeat	Method
AGGAAAGCGTTTTGCTGAGTTAACGCGACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011410_1

>merge|NZ_CP011410|1|1201469-1201563|CRISPRCasFinder
AGGAAAGCGTTTTGCTGAGTTAACGCGACCTATCTCGCGACCCGTTGGGAGTGAGATTTGAGTTCAGGAAAGCGTTTTGCTGAGTTAACGCGACC

>NZ_CP011410|1|1|1201469-1201563|CRISPRCasFinder
AGGAAAGCGTTTTGCTGAGTTAACGCGACC	TATCTCGCGACCCGTTGGGAGTGAGATTTGAGTTC
AGGAAAGCGTTTTGCTGAGTTAACGCGACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011410.1\|WP_002072562.1\|1194471_1195434_-\|porin-OmpL1	unknown	unknown	gnl\|CDD\|371504
NZ_CP011410.1\|WP_000344511.1\|1212162_1212342_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000562954.1\|1209626_1210595_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl\|CDD\|335469
NZ_CP011410.1\|WP_000844448.1\|1208035_1209556_-\|peptidase-M14	unknown	unknown	gnl\|CDD\|349432
NZ_CP011410.1\|WP_000729232.1\|1204746_1205901_-\|TauD/TfdA-family-dioxygenase	unknown	unknown	gnl\|CDD\|165707
NZ_CP011410.1\|WP_025178656.1\|1206647_1206968_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000013216.1\|1202746_1203850_+\|rhodanese-related-sulfurtransferase	unknown	unknown	gnl\|CDD\|234663
NZ_CP011410.1\|WP_000394091.1\|1212437_1212857_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|292206
NZ_CP011410.1\|WP_001156916.1\|1203833_1204742_-\|bile-acid:sodium-symporter-family-protein	unknown	unknown	gnl\|CDD\|223462
NZ_CP011410.1\|WP_000345343.1\|1199311_1200493_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378964
NZ_CP011410.1\|WP_001079907.1\|1193417_1194368_+\|cytochrome-c-peroxidase	unknown	unknown	gnl\|CDD\|224771
NZ_CP011410.1\|WP_000232010.1\|1190734_1191991_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NZ_CP011410.1\|WP_000063748.1\|1197062_1198274_-\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|236197
NZ_CP011410.1\|WP_001071499.1\|1189380_1190553_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP011410.1\|WP_000483730.1\|1210596_1211658_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_001166988.1\|1186776_1187163_+\|cation-transporter	unknown	unknown	gnl\|CDD\|224987
NZ_CP011410.1\|WP_016689547.1\|1190549_1190648_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000944884.1\|1185865_1186699_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP011410.1\|WP_000499950.1\|1187678_1188755_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271323
NZ_CP011410.1\|WP_000468416.1\|1207130_1208036_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769

Protein	Function_ID	Function_description	E-value
NZ_CP011410.1\|WP_002072562.1\|1194471_1195434_-\|porin-OmpL1	gnl\|CDD\|371504	pfam11389, Porin_OmpL1, Leptospira porin protein OmpL1. OmpL1 is a member of the outer membrane (OM) proteins in the mammalian pathogen Leptospira. Specifically, it is a porin.	6.46288e-136
NZ_CP011410.1\|WP_000394091.1\|1212437_1212857_-\|hypothetical-protein	gnl\|CDD\|292206	pfam15571, Imm44, Immunity protein 44. A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI1, Tox-URI2 or Tox-ParBL1 families. The gene for this toxin is also found in heterogeneous poly-immunity loci that show variations in structure even between closely related strains.	3.22615e-44
NZ_CP011410.1\|WP_000562954.1\|1209626_1210595_+\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl\|CDD\|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	9.25967e-48
NZ_CP011410.1\|WP_000844448.1\|1208035_1209556_-\|peptidase-M14	gnl\|CDD\|349432	cd03859, M14_CPT, Peptidase M14 Carboxypeptidase T subfamily. Peptidase M14-like domain of carboxypeptidase (CP) T (CPT), CPT belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. CPT has moderate similarity to CPA and CPB, and exhibits dual-substrate specificity by cleaving C-terminal hydrophobic amino acid residues like CPA and C-terminal positively charged residues like CPB. CPA and CPB are M14 family peptidases but do not belong to this CPT group. The substrate specificity difference between CPT and CPA and CPB is ascribed to a few amino acid substitutions at the substrate-binding pocket while the spatial organization of the binding site remains the same as in all Zn-CPs. CPT has increased thermal stability in presence of Ca2+ ions, and two disulfide bridges which give an additional stabilization factor.	4.03103e-57
NZ_CP011410.1\|WP_000729232.1\|1204746_1205901_-\|TauD/TfdA-family-dioxygenase	gnl\|CDD\|165707	PLN00139, PLN00139, hypothetical protein; Provisional.	4.43768e-29
NZ_CP011410.1\|WP_000013216.1\|1202746_1203850_+\|rhodanese-related-sulfurtransferase	gnl\|CDD\|234663	PRK00142, PRK00142, rhodanese-related sulfurtransferase.	1.835e-152
NZ_CP011410.1\|WP_001156916.1\|1203833_1204742_-\|bile-acid:sodium-symporter-family-protein	gnl\|CDD\|223462	COG0385, COG0385, Predicted Na+-dependent transporter [General function prediction only].	2.82121e-51
NZ_CP011410.1\|WP_000345343.1\|1199311_1200493_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|378964	pfam12833, HTH_18, Helix-turn-helix domain.	7.25684e-15
NZ_CP011410.1\|WP_001079907.1\|1193417_1194368_+\|cytochrome-c-peroxidase	gnl\|CDD\|224771	COG1858, MauG, Cytochrome c peroxidase [Inorganic ion transport and metabolism].	2.26807e-53
NZ_CP011410.1\|WP_000232010.1\|1190734_1191991_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	9.39235e-163
NZ_CP011410.1\|WP_000063748.1\|1197062_1198274_-\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|236197	PRK08242, PRK08242, acetyl-CoA C-acetyltransferase.	0
NZ_CP011410.1\|WP_001071499.1\|1189380_1190553_+\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.02705e-140
NZ_CP011410.1\|WP_001166988.1\|1186776_1187163_+\|cation-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	1.20551e-05
NZ_CP011410.1\|WP_000944884.1\|1185865_1186699_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.18791e-15
NZ_CP011410.1\|WP_000499950.1\|1187678_1188755_-\|hypothetical-protein	gnl\|CDD\|271323	cd14953, NHL_like_1, Uncharacterized NHL-repeat domain in bacterial proteins. This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.	7.1538e-57
NZ_CP011410.1\|WP_000468416.1\|1207130_1208036_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	4.83389e-15

>NZ_CP011410.1|WP_000345343.1|1199311_1200493_-|AraC-family-transcriptional-regulator
MDFFPDLNFLDYLIFVKEVLNRYLEYLYSASIVISFLTGLSGFYKATKNRLNFVRGIFLMSACFLIIGHSKAFSLMTSDPNGILSLEKRVFFSYYYGFAVCASLSSTFYVMYLFGALKNPLRLSLYSFLSFPTIFLISLMIENLISIVYFGKSVLFTLQFSAGIFNLYYVIKYKMKKIYLNYPIQNFTLCTALIVHSIGMWLGTPNLMILALSFTGFFIIYFFILEYNHPEFWKVSFSSELIEIKSEDNKIQTLQTNTSSKNLVERLDISRIEEKIQKFVEDREYLDEEIRLSDFSAYIGLSLHQASYYLNNYKDLSFTDFLSFHRLEEAKRMIEQRPDINLLEVALASGFNSPSSFRRACLKFTGKPPKEFRNYVLHQTTPSITLELQNQLG
>NZ_CP011410.1|WP_000063748.1|1197062_1198274_-|acetyl-CoA-C-acetyltransferase
MSNAYVIDAVRTPRGKGKKRGALASIHPQELSAATLNAIQERNGIKPEIVEEVVMGCVSQVDDQAACIARYAVMSALWPNSVPGYTVNRFCGSGLQAVNNAANHVQSGSMQIALGGGVESMSRVKMGADMNGRDFNIGNPNIQKHYNLVPQGISADLIATKFGISREEADRFAESSQIKADKAIKEGYFKKSIIPVKTEDGTIVDSDENPRIESTFEWLSDLAPVFKTIGEKELDAIALKSYPEIPKINHIHTLGNSSGIVDGAASVLLASDEGIKKYGLKPRARIVAMASTGEDPTIMLTGPVSASKKALAMAGLKPEDIDLWEINEAFASVVLYTQKSLGIPIEKINVNGGSISLGHPLGATGAILLGTALDELERRQKRYALITLCIGGGMGIATIIERI
>NZ_CP011410.1|WP_002072562.1|1194471_1195434_-|porin-OmpL1
MIRNISKALLILAVALSSAASLSAKTYAIVGFGLQLDLGQLGGTITKDGLDAASYYGPVRSTDTCTVGPNDPTCVQNPGKPTGEGNYLGVAPRKAIPAENKLITLDRTTGGLINARSTKGAMVGGNLMVGYESDFGKYFFWRVAAEYTQKISGGITKADIAGYNIVDMTWGFSSIVIPATVGIKLNVTEDAAIYMGAGLNYFNGGWSLNGSNNLKGGHDILAAAGAGSVANLIADGTDPVTTREHVRFRTSGIAPNFLIGTQARVTDKGHVFLELETIMSAAYAVGKTQSAGGATNLSPFPAYPIVVGGQIYRFGYKHEL
>NZ_CP011410.1|WP_001079907.1|1193417_1194368_+|cytochrome-c-peroxidase
MNRILSIFTFISVLFLLSGCKEPDQKMELESFVVKNIIHPNNNPYNKDKVELGKLLYFDKRLSLKGDTNCAICHSVEIRDLEKNSLPKNKIHNSSAPSLTNVGLYKDVFMDSQANDLEEIVKERIHTAVMLKDEKTIVARLNRVQTYRELFEKSFGSPGITMDRIVKAISAFERTILSKNSKFDRYVMGEESALSPAQKRGLDVFMNKAKCFQCHKGPNFSDSEKHTTGLSGITQKVRTPSLRDVSKKNKFMHNGEFTNLEDVVNHFVNGGAKDSIQDPLLKESTITEEEKKDLVEFLKSLEGEFQLLEIPKIPKA
>NZ_CP011410.1|WP_000232010.1|1190734_1191991_+|acyl-CoA-dehydrogenase-family-protein
MVFSFIFWFDLITVKKKVGLEYSLKIRRAKPMYQEFTEQQLEIRDQIRNFVKKEITHEVAIHWDEENKHPEELINRMRKELGVNGLTIPEEYGGWGLGSVEQCLVTEELSRGCLGISLCFGYTGLGILPILKGASHEQKKKWLQPVVDGEYGVSFCLSEPGAGSDVPGMSTTAVKKGDKWVINGTKQWITGGGSAGAYTVFAYTDKGRGTRGVSCFYVKRDTPGLTVGKKEDKLGIRASDTRQIIFEDCAVEEANMIGKENLGFIYALQTLNASRPYVAAMGVGVAQAALDYASKYARQREQFGSKISSFQAVQHMLADMSIGLETSRQVTYLAARMSDADDPRLPKYSAIAKAHASETAMKCALDAVQIFGGYGYTKEYPVEKLMRDAKILCIFEGTTQIQKNEIAAYVIREAASAK
>NZ_CP011410.1|WP_016689547.1|1190549_1190648_+|hypothetical-protein
MNFIGKQLEDTKYFLNYKHSKNCEQNVRSLKF
>NZ_CP011410.1|WP_001071499.1|1189380_1190553_+|CoA-transferase
MNQGPLSGIKVIDLSLLLPGPLCSMYLGDMGAEIIKVENPRAMDATRVMFKKANGAPSLYLMLNRNKKAITLNLKKEKSREILFKLLENADILLEGFRPDGLAKMGYGYDDLKERFPKLIYCGIYGYGTEGKYRNFAGHDVNYLSLSGVLSQTGKTPQIPGYQLADIGGGTMTALSSILAALYAREKTGKGQKISVSMMDSSLPFLSLYGGIYGATGKNPEGGNELLSGKLPNYNVYQTKEGRWVALGALEDMFFKTFLRQTGLDKHLEELPAEEKNFSKWKEILTTYFSTKTFEDLNVLFENQDSCLTPVKTIEEVIKDPVFQESGMVIEKKHPDYGDYFQFGAPFSFSETPVTYRLDPPSHGEHNESIYRTLGYTVEEIETMKKEKVI
>NZ_CP011410.1|WP_000499950.1|1187678_1188755_-|hypothetical-protein
MFYRILIFVLVLVSCSPASIYNPSIFMSQAWIENTILDCILKECYLCSLKITNKPVVSLFAGTGVAASVDGTTSTASFKTPFGLEVDTSGNIYVSDQINNLIRKIDPSGNVKTLSTNLPLQDPSGIKFDPLTGDKYVSCKDSNQIYKIDSTEQFSLFAGSSSDLSGLQNGDRLNSLFDSPFFMDIDPERNLYVGELSNHTIRKINLNSGTVSTLSGGISGYLDGDLASARFKSPLGIAYNRKMNSLLAADIQDHRIRKIDLKNSTVSTLLGNGIGADVDGNGTNASFFGPAFISIDNSGYMFVSDANSNRIRIVDPLLNVSTIDHTFMEIGTVKVDCLNQRLLVADSRANQIFQVKFE
>NZ_CP011410.1|WP_001166988.1|1186776_1187163_+|cation-transporter
MQIQVLVVFIIALVFNALANILIKASSLKDVSEKPDGIQGMLQVIFNPMFIGGLASFGLALLGYRFVLGKGLKLSLAYPVFTSAGFILVLIVSSIAFKERLTWSQWAGIILILVGVWLCAANMFETKS
>NZ_CP011410.1|WP_000944884.1|1185865_1186699_-|alpha/beta-hydrolase
MLRKTFNFQGLNLSYIDTNSKSKPTILLCHANGYSAFTYKFYIESLQNSHRVIALDFAGHGESDSTLNFRDWYFFRDQVLSLIESENLNNVIGIGHSLGGASLLLASYHSPDKFKKVIAHDPVTLNFLQITYSRIFHNPLAQVAIKRRREFKNLDTVRKIYKRTPSFSRWDNGIYDDYIQSCFRLGVNGEAILRCAPEVEAKIFDSVSYRSLFQFGKIKTETHITIPDPHEVCSPNTAKKIISGNIRSSLEIWPKTSHFFPFEEKHKTLDRILRVLD
>NZ_CP011410.1|WP_000013216.1|1202746_1203850_+|rhodanese-related-sulfurtransferase
MANQGDFPKRTETKKRPLHNIYGKEILRKRLEEENFSRTTLSFYRYVILENVQELRDQLYAEWEILGVLGRIYIAREGINAQLSIPSHNLDFFRKNLDSRNQFKDMQFKIAVEDDSKSFLKLDLKIKKKIVADGLNDDAFDVTNVGKHLSAEEFNLHMEDENSIVVDVRNHYESEIGHFENAILPQSDTFREELRILLELLNGKENHKILMYCTGGIRCEKASAWLKHHGYKDVNQLHGGIISYAHEVSQKGLESKFKGKNFVFDGRLQEAIGNEVISSCHQCGAKCDRHVNCENPGCHVLFIQCPSCSEKFEGCCTLECQNVLHLPKEKQKEIRKGKLNENRFFSKSKIRPKISELYHGILFKSSK
>NZ_CP011410.1|WP_001156916.1|1203833_1204742_-|bile-acid:sodium-symporter-family-protein
MQELDSVRIHFNESNLAFLNLLLGLIMYGIALELRFEDFKLLVDKPRSSITGILSQFILFPFATYLLLWILNPSPGIALGMLLVAACPGGNISNFVTLLAKGNTALSISLTAFSSALAIVITPFNFFFWGNLYPPVQNTLRTISLNPWDVLKAILMILIIPILLGLLTKKFLPKTTAKIVKPIRILSAIIFAAFLLIALFANFQIFLNVIYKVFLYVFLMNAVGFLLGYYFSKLMRLDERDSRCISIETGIQNSGLGLVLIFAFFEGQGSMAIIAATWGIWHAIAGVTLAWFWSKKTSTLKT
>NZ_CP011410.1|WP_000729232.1|1204746_1205901_-|TauD/TfdA-family-dioxygenase
MAAKTFSKTKIKKGKPSTKSNTKKQTKLKITSSGIKLSKSFFNPKNPLPVIYQPNSTTQKSKQTLIQWIKTNKRVLTDDLKQYGAILFRGFEIISPQDFEEVILNIDSNLKNNYLGTSPRNQVTKYTFTATELPSAYPIMQHAEMSFLDSPPKKLFFYCGKAPGKFGETPITDLRKVLKEIPTHIREKFEKEKIRYSRVYNGPSNQSRFQFWKTKRWDEMFQTKDKNEVEKTSKKQNFKVEWFGKDDLRLVNTTLAIRKHPESNTLAWHNHSQVFHIDAARKEYWKIFVRQKTIRGFLVAVTLEILTFIKKITTKKEYLDTHCTYGGGQEISGTELKQIQNVFWNNISLFSWQNGDILVIDNYSVSHGRHPFTGPREIFVAWAD
>NZ_CP011410.1|WP_025178656.1|1206647_1206968_-|hypothetical-protein
MICESSRNFRKPEYSVYQTNVELSQISRAILRKLTRDLNQREFGITRKGLMPGKLSRTLSQTKAVLLLWALEVTQRLASMGARQIVFYNQLKLKMNIILRFLYTIY
>NZ_CP011410.1|WP_000468416.1|1207130_1208036_-|DMT-family-transporter
MFHIRHEIYLILCTLIWGGTFTMTIFGLRDTSPSIFLGLRFGIASMIFLPFAWKEFRKGKIWYPGAFLLGMFLYLGFACETIGLKTTTATKSSFLIGTLVVITPIFEAILKKRMPGKGNLLGASVVFTGICLIFAGEIGMEGTLTITNGDWITLGGAIFFSLYIIQMDRVSIQIPIRISVFYQSFVAGFFALISVIILHFVGIEKVRLNPSARLIPGVLYNALLASVLTTFLQTKFQRYVSPTRVGIIFSLEPVFSSIIAFLLLGEKSGPVRIVGCTIVFLGLILAESIGKDQNLSMENTN
>NZ_CP011410.1|WP_000844448.1|1208035_1209556_-|peptidase-M14
MKSYLPSNTIFIVYICLFLFVSCAGFFRKKIPNSPLNDPRKMILVRIDPGRLGEFKEKTGGKYNISYQESDSYYSVINKQDIDKFGFPSPGISVVKQYLPFKYYSGNYQELINERFTSLEDLKKGYKDNILNIHYLLGIANLYSEQSRMEVIGKTARGREIPALLLTNTTTPDEEKISVLFNCAHHANEVISIEHCYDIIYSVLSRPKEYQEILNKMKIWIVPIVNPDGARHFWHVSNLMGRKNGYPGSGPVNDKLNPGVDINRNYPFYWGKAGGGYSSSNPSNYFYRGPSPGSESETKAMMDLANRERFAASISYHAYANCLLIPYSIDSLNNPEPDVAKEIGKKIAASVTSLNPEKEFEAKKNIYPIDGVDQDYFYFAHGTLAYLLETTHLNPEYKEVEKVNVSLRKAWNLLLNEVLEGKKIFLKITDEFGTPLEAKVEIERIKYFQEEIRVSNPINGFFFQLFPDRKETKVKISKEGYEPTEIQTRPNGKWEPLKIVLKKNRI
>NZ_CP011410.1|WP_000562954.1|1209626_1210595_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MICPFRFSVYPHSKRFCLSFKSFWLGPYMKSKIRNFLFLVVMILIAHWGWMCKLLADPSACGGKEIPGMKCIPAGEFIRGSNVYDADEKPEEKVYVSDFYMDIYEVTNEDFDKCKNAGKCQECLKTGKCNYIGPRYGKPYLGPKQPVTGISWYTAKEFCEWAGKRLPTEAEWEKAARGPNGNLYPWGNEPATCERAIIEVGDIKGCVPKKTEKPHLMPTANVGTRAPGVYGLYDMAGNSWEWTADWYSTSFKACGNFCRGKDPKGPCDGKEVCPGYKKKVLKSGSWWWPAHYARGSKRRSHIPENFPEYHHFGFRCAKDVNK
>NZ_CP011410.1|WP_000483730.1|1210596_1211658_+|hypothetical-protein
MFNYSKLGIYVVLMFFSFIFLFCSGPKKIEESQNVSLNEGNIVSKLKETPQETLVPTKWDVGDTTVSNEDRLDLLIPHVQNLGNVYVGVGSEQNLTIAAWAKSDFIYLMDFTQIVVHANTITILFLQKGEKKEDFIRLWGKEGEKEALELIQVSFSDPEVYKKVYKQASPFIRKRHKTNLMLSKKYNYKMFQTDDEQYSYIRKLAIEGKILPIRGNLLGNITLTGIGNTLKKIGRKVGIIYFSNAEEYFAYPQEFKNSILNLPVSESSLVVRTISVRKDLFPWSPGSEISTDRGFHYCVQKISNFQKWLSSGKPGLRSLQVMVEGGTVDKKNGITVVDKEPVVTEDKLPKTGG
>NZ_CP011410.1|WP_000344511.1|1212162_1212342_-|hypothetical-protein
MDESGLLQVAGQGSQLWSINCIQEAQYNIHLKFQLIIEHDLSSERDAELLRATIEARQL
>NZ_CP011410.1|WP_000394091.1|1212437_1212857_-|hypothetical-protein
MEFFISSEIDGRFSQNVPDKFRRVRKNVGSILNKHFLDKDYGANIKSIGVIPILIRTDLKEFYKERKLYQKKQNSADYRLYIDFESFEKANDDIATNLLIQNILAVVQDLGRKVSSFDATSLENEIKNLFPLYISHNVH

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Crispr_ID: NZ_CP011410_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011410_2

1271786-1271895

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	CRISPRCasFinder

1 spacers

cas6,cas8b3,cas7,cas5,cas2,cas1

The CRISPR arrays of NZ_CP011410_2

>merge|NZ_CP011410|2|1271786-1271895|CRISPRCasFinder
GTCTAAATCGCCTAACGGCATCAAAGTTATATTCAGTGGGTCGCTCAATCTCTTGACCTTACATTAAATGATGTGCTCAACGCCTACCGGCACCCGATTTTTGTAAGTTT

>NZ_CP011410|2|2|1271786-1271895|CRISPRCasFinder
GTCTAAATCGCCTAACGGCATCAAAGTTATATTCAGT	GGGTCGCTCAATCTCTTGACCTTACATTAAATGAT
GTGCTCAACGCCTACCGGCACCCGATTTTTGTAAGTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011410.1\|WP_000141532.1\|1256000_1259099_-\|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223683
NZ_CP011410.1\|WP_000683530.1\|1273296_1273581_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP011410.1\|WP_000511226.1\|1273580_1275206_-\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP011410.1\|WP_000533549.1\|1263218_1263401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_029764174.1\|1272988_1273180_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000841973.1\|1282118_1283192_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP011410.1\|WP_000199611.1\|1261502_1263044_-\|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl\|CDD\|211578
NZ_CP011410.1\|WP_000371341.1\|1265007_1265631_-\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP011410.1\|WP_000451411.1\|1277561_1277774_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_001072141.1\|1277957_1278344_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_001110344.1\|1278686_1279238_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000061288.1\|1259116_1260268_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|372509
NZ_CP011410.1\|WP_000236257.1\|1264288_1264621_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000590873.1\|1280341_1281838_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP011410.1\|WP_000052104.1\|1265651_1266491_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP011410.1\|WP_000026911.1\|1270739_1271372_-\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP011410.1\|WP_000098765.1\|1266555_1268439_-\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP011410.1\|WP_082267386.1\|1275684_1275894_-\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP011410.1\|WP_000578381.1\|1276424_1277300_-\|PcfJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP011410.1\|WP_001140542.1\|1263393_1263822_-\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269

Protein	Function_ID	Function_description	E-value
NZ_CP011410.1\|WP_000141532.1\|1256000_1259099_-\|type-I-restriction-endonuclease-subunit-R	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	0
NZ_CP011410.1\|WP_000683530.1\|1273296_1273581_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP011410.1\|WP_000511226.1\|1273580_1275206_-\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP011410.1\|WP_000841973.1\|1282118_1283192_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	8.59013e-27
NZ_CP011410.1\|WP_000199611.1\|1261502_1263044_-\|type-I-restriction-modification-system-subunit-M	gnl\|CDD\|211578	TIGR00497, hsdM, type I restriction system adenine methylase (hsdM). Function: methylation of specific adenine residues; required for both restriction and modification activities. The ECOR124/3 I enzyme recognizes 5'GAA(N7)RTCG. for E.coli see (J. Mol. Biol. 257: 960-969 (1996)). [DNA metabolism, Restriction/modification].	0
NZ_CP011410.1\|WP_000371341.1\|1265007_1265631_-\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	9.87123e-100
NZ_CP011410.1\|WP_000590873.1\|1280341_1281838_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	2.21093e-156
NZ_CP011410.1\|WP_000061288.1\|1259116_1260268_-\|AAA-family-ATPase	gnl\|CDD\|372509	pfam13166, AAA_13, AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.	7.75223e-07
NZ_CP011410.1\|WP_000052104.1\|1265651_1266491_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	9.32745e-84
NZ_CP011410.1\|WP_000026911.1\|1270739_1271372_-\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	6.95928e-102
NZ_CP011410.1\|WP_000098765.1\|1266555_1268439_-\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	6.46036e-165
NZ_CP011410.1\|WP_082267386.1\|1275684_1275894_-\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.92572e-10
NZ_CP011410.1\|WP_000578381.1\|1276424_1277300_-\|PcfJ-domain-containing-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP011410.1\|WP_001140542.1\|1263393_1263822_-\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15

>NZ_CP011410.1|WP_000026911.1|1270739_1271372_-|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPTLHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP011410.1|WP_000098765.1|1266555_1268439_-|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLSECTSPLLRAGLAGLYSTLYSLENEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRTKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKKSRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP011410.1|WP_000052104.1|1265651_1266491_-|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFPGIKAAVEDAKKRIGKSA
>NZ_CP011410.1|WP_000371341.1|1265007_1265631_-|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSGRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDINSSSLTSKMRFSFQSAEGIPENAWFKLRPS
>NZ_CP011410.1|WP_000236257.1|1264288_1264621_+|hypothetical-protein
MVINARKKSKRRFQLKQAQPFLSSQDIFCEGMTIKSGETGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDINVWLFAFWRELSPNGIKVIFRQWPLYCVLNA
>NZ_CP011410.1|WP_001140542.1|1263393_1263822_-|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP011410.1|WP_000533549.1|1263218_1263401_+|hypothetical-protein
MGRRGKIATEHNASEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK
>NZ_CP011410.1|WP_000199611.1|1261502_1263044_-|type-I-restriction-modification-system-subunit-M
MTSAQQRAALQRQIWQIANDVRGAVDGWDFKQYVLGTLFYRFISENFTNYMEGGDSSIQYSKLNDKKITKEIKDDAIKTRGYFIYPSQLFANIVTKADKNERLNTDLAGIFKDIESSANGFPSEHDIKGLFADFDTTSNRLGNTVKDKNSRLAAVLKRVAELDFGDFDSSHIDLFGDAYEFLISNYAANAGKSGGEFFTPQHVSKLIARLAIHKQTRINKIYDPACGSGSLLLQAKKQFDDHIIEEGFFGQEINHTTYNLARMNMFLHNINYDKFDIELGNTLIDPQHNHEKPFDAIVSNPPYSINWKGSDDPTLINDERFAPAGVLAPKSKADFAFVLHALSYLSSKGRAAIVCFPGIFYRSGAEQKIRQYLVGNNFVETVISLAPNLFFGTTIAVNILVLSKHKTDTNTQFIDASGLFKKETNNNILTEDHIERIMQTFDSKVDMEHFAKSVSVETIANNDYNLSVSSYVEAKDNREVIDIQKLNAELKTTVAKIDQLRADIDAIVAEIEG
>NZ_CP011410.1|WP_000061288.1|1259116_1260268_-|AAA-family-ATPase
MSMDIAKLLKDADQKVQLLYAFNGTGKTRLSREFKQLVAPKNNRDEADQAESSHNKILYYNAFTKNLFYWDNDLEKDAEPKLKIQSNSFTDWILKDQGQDRNIITNFQHYTNEKLTPRFNEAYTVKDKNEQEVIVKEFSEVTFSLTRGNEERSGNLKISKGEESNFIWSIFYSLLEQVISVLNVIDSSEQETDQFDQLEYVFIDDPVSSLDENHLIELAAELIQSSKSDIRFLITTHNPLFYNVLHNEFKKDTFKKYILKKQEDESYELANQSTDSPFSYHLHLKAELEKAIETGQLHKYHFNFLRNILEKTSTFVGLEKWEDLLPKTEDGDPNPYEVRIINFSSHSKHSDNEVVEVPDEHRRVLSFLVKKLDEMYRLRMRTK
>NZ_CP011410.1|WP_000141532.1|1256000_1259099_-|type-I-restriction-endonuclease-subunit-R
MTEYKTIAESNHFIVLDKYNREWQVSESYQSEADLEKELVQDLKNQGYEFRTDISTPEKMLANVREKLQALNAMQFSEGEWLRFVETWLDKPSDTVIDKTRKIHDDYIHDFVFDDGHIQNIYLLDKKNIARNKVEVIRQFEQAGTHSNRYDVTILVNGLPLVQIELKKRGVAIREAFNQIHRYSKESFNSEHSLFKYLQLFVISNGTDSRYFANTTHRNKNSFDFTMNWAKADNSLMKDLKDFTATFFQKNTLLNVLLTYSVFDVSDTLLVMRPYQIAATERILWKIKSSFGTKNWSKPESGGYIWHTTGSGKTLTSFKAARLSTELDFIDKVFFVVDRKDLDYQTMKEYQRFSPDSVNGSDSTAGLKRNLEMDDNKIIVTTIQKLNNLIKSESDLSIYNKQVVFIFDEAHRSQFGEAQKNLRKKFKKFYQFGFTGTPIFPQNALGADTTASVFGRELHSYVITDAIRDEKVLKFKVDYNDVRPKFKEIETEQDEKKLTAAENKQALLHEERIREISQYILNQFKQKTHRLQPSSKGFNAMFAVSSVDAAKLYYESFKEVQKDQDKPLKVATIFSFSANEEQDAVGEIQDESFEVSAMESTAKEFLSAAINDYNIMFQTNFGVDSNSFQNYYRDLAKKVKDREIDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLLQAYSRTNRIYDATKTFGNIITFRDLEKATIEAITLYGDKNTKNVVLEKSYKEYMEGFTDLATGEARRGYVDVVAELQQRFPKPEEIEKESDKKAFVKLFGEYLRVENVLQNYDEFTSLKALQNIDMSNQEAVEEFKAKHYVSDEGLAALQKIQVPAERKIQDYRSTYNDIRDWLRRQKSGDEKVKPRIDWDDVVFEVDLLKSQEINLDYILELIFEHNKKVKNKSILIEDIRRVIRASIGNRAKESLMIDFINQTDLDQISDKASVIDAFFSFAQTEQKREADELIQTENLNAEAAKRYITSSLRREFASENGTELNTILPKMSPLHPQYLTIKQSVFQKVSAFVEKFKGVGGQI
>NZ_CP011410.1|WP_029764174.1|1272988_1273180_+|hypothetical-protein
MSVFKGGEQVYRFLSLFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWPIIR
>NZ_CP011410.1|WP_000683530.1|1273296_1273581_-|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP011410.1|WP_000511226.1|1273580_1275206_-|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKAIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALIKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP011410.1|WP_082267386.1|1275684_1275894_-|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHRLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP011410.1|WP_000578381.1|1276424_1277300_-|PcfJ-domain-containing-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP011410.1|WP_000451411.1|1277561_1277774_+|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP011410.1|WP_001072141.1|1277957_1278344_-|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVLFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP011410.1|WP_001110344.1|1278686_1279238_-|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIEIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP011410.1|WP_000590873.1|1280341_1281838_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MIKISGLNKAFTTKVLFDDLNLSINRGEKVGLVGRNGHGKSTLFQVILGNVEADSGTISIPKGYKIGHLQQHLHFTKPTVREECSLGLPEGEEYETWKVEKILSGLGFSEQDMEKNPNEFSGGYQIRMNLAKLLVSSPDMLMLDEPNNYLDIVTIRWLEEFLREWEGEIILVTHDRGFMDAVVTHTIAIHRTKAIKVQGDTDKLYNQINQSEEIYEKTRLNEAKKRKQEEIFIAKFKAKASFASRAQSRVKKLEKQGEMKELEKIQDLELYFNSAPFNANQMLSAENLSFSYDGKEPFLIENFSISVGSRERICIIGKNGKGKSTLLKILAGELETSQGTIKKHPVLKEGYFGQTNKLNLNENSTVVEEIMISDPSCNEWKARTIAGGLMFSEDQALKKIKVLSGGEKSRVLLGKILVTPCHLLYLDEPTNHLDMQSCDSLIEAIDEFDGSVIMVTHDELHLRAVATKLIVFDNDSIQIFNGSYDDFLNDVGWSNEHY
>NZ_CP011410.1|WP_000841973.1|1282118_1283192_-|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGVGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM

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Crispr_ID: NZ_CP011410_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011410_4

1272623-1272947

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	CRISPRCasFinder
GTGCTCAACGCCTANCGGCATCAAAGTTATATTCAGA	CRT
GTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGA	PILER-CR

4 spacers

cas6,cas8b3,cas7,cas5,cas2,cas1

The CRISPR arrays of NZ_CP011410_4

>merge|NZ_CP011410|4|1272623-1272947|CRISPRCasFinder,CRT,PILER-CR
ATCTAAACCGCCTAACGGCATCAAAGTTATATTCAGCAATGTTATCCGGCTTGATTATCGCGGGAGGCAGGTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGAGAAAAAAACCCGTTCCCGAACGGAGAAGGGGAATTGTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGAAAATTGCATATAAGACTACAGATATGGTTGTTAAGTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGACCAAGCGTTTCCCTACCTGTAAAAAAACCTGTTATGCTGTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGA

>NZ_CP011410|4|4|1272623-1272947|CRISPRCasFinder
ATCTAAACCGCCTAACGGCATCAAAGTTATATTCAGC	AATGTTATCCGGCTTGATTATCGCGGGAGGCAG
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	GAAAAAAACCCGTTCCCGAACGGAGAAGGGGAATT
GTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGA	AAATTGCATATAAGACTACAGATATGGTTGTTAA
GTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGA	CCAAGCGTTTCCCTACCTGTAAAAAAACCTGTTATGCT
GTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGA

>NZ_CP011410|4|2|1272623-1272947|CRT
ATCTAAACCGCCTAACGGCATCAAAGTTATATTCAGC	AATGTTATCCGGCTTGATTATCGCGGGAGGCAG
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	GAAAAAAACCCGTTCCCGAACGGAGAAGGGGAATT
GTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGA	AAATTGCATATAAGACTACAGATATGGTTGTTAA
GTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGA	CCAAGCGTTTCCCTACCTGTAAAAAAACCTGTTATGCT
GTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGA

>NZ_CP011410|4|2|1272693-1272947|PILER-CR
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	GAAAAAAACCCGTTCCCGAACGGAGAAGGGGAATT
GTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGA	AAATTGCATATAAGACTACAGATATGGTTGTTAA
GTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGA	CCAAGCGTTTCCCTACCTGTAAAAAAACCTGTTATGCT
GTGCTCAACGCCTACCGGCATCAAAGTTATATTCAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011410.1\|WP_000141532.1\|1256000_1259099_-\|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223683
NZ_CP011410.1\|WP_000683530.1\|1273296_1273581_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP011410.1\|WP_000511226.1\|1273580_1275206_-\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP011410.1\|WP_000533549.1\|1263218_1263401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_029764174.1\|1272988_1273180_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000841973.1\|1282118_1283192_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP011410.1\|WP_000199611.1\|1261502_1263044_-\|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl\|CDD\|211578
NZ_CP011410.1\|WP_000371341.1\|1265007_1265631_-\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP011410.1\|WP_000451411.1\|1277561_1277774_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_001072141.1\|1277957_1278344_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_001110344.1\|1278686_1279238_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000061288.1\|1259116_1260268_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|372509
NZ_CP011410.1\|WP_000236257.1\|1264288_1264621_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000590873.1\|1280341_1281838_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP011410.1\|WP_000052104.1\|1265651_1266491_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP011410.1\|WP_000026911.1\|1270739_1271372_-\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP011410.1\|WP_000098765.1\|1266555_1268439_-\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP011410.1\|WP_082267386.1\|1275684_1275894_-\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP011410.1\|WP_000578381.1\|1276424_1277300_-\|PcfJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP011410.1\|WP_001140542.1\|1263393_1263822_-\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269

Protein	Function_ID	Function_description	E-value
NZ_CP011410.1\|WP_000141532.1\|1256000_1259099_-\|type-I-restriction-endonuclease-subunit-R	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	0
NZ_CP011410.1\|WP_000683530.1\|1273296_1273581_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP011410.1\|WP_000511226.1\|1273580_1275206_-\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP011410.1\|WP_000841973.1\|1282118_1283192_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	8.59013e-27
NZ_CP011410.1\|WP_000199611.1\|1261502_1263044_-\|type-I-restriction-modification-system-subunit-M	gnl\|CDD\|211578	TIGR00497, hsdM, type I restriction system adenine methylase (hsdM). Function: methylation of specific adenine residues; required for both restriction and modification activities. The ECOR124/3 I enzyme recognizes 5'GAA(N7)RTCG. for E.coli see (J. Mol. Biol. 257: 960-969 (1996)). [DNA metabolism, Restriction/modification].	0
NZ_CP011410.1\|WP_000371341.1\|1265007_1265631_-\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	9.87123e-100
NZ_CP011410.1\|WP_000590873.1\|1280341_1281838_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	2.21093e-156
NZ_CP011410.1\|WP_000061288.1\|1259116_1260268_-\|AAA-family-ATPase	gnl\|CDD\|372509	pfam13166, AAA_13, AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.	7.75223e-07
NZ_CP011410.1\|WP_000052104.1\|1265651_1266491_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	9.32745e-84
NZ_CP011410.1\|WP_000026911.1\|1270739_1271372_-\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	6.95928e-102
NZ_CP011410.1\|WP_000098765.1\|1266555_1268439_-\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	6.46036e-165
NZ_CP011410.1\|WP_082267386.1\|1275684_1275894_-\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.92572e-10
NZ_CP011410.1\|WP_000578381.1\|1276424_1277300_-\|PcfJ-domain-containing-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP011410.1\|WP_001140542.1\|1263393_1263822_-\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15

>NZ_CP011410.1|WP_000026911.1|1270739_1271372_-|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPTLHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP011410.1|WP_000098765.1|1266555_1268439_-|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLSECTSPLLRAGLAGLYSTLYSLENEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRTKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKKSRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP011410.1|WP_000052104.1|1265651_1266491_-|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFPGIKAAVEDAKKRIGKSA
>NZ_CP011410.1|WP_000371341.1|1265007_1265631_-|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSGRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDINSSSLTSKMRFSFQSAEGIPENAWFKLRPS
>NZ_CP011410.1|WP_000236257.1|1264288_1264621_+|hypothetical-protein
MVINARKKSKRRFQLKQAQPFLSSQDIFCEGMTIKSGETGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDINVWLFAFWRELSPNGIKVIFRQWPLYCVLNA
>NZ_CP011410.1|WP_001140542.1|1263393_1263822_-|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP011410.1|WP_000533549.1|1263218_1263401_+|hypothetical-protein
MGRRGKIATEHNASEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK
>NZ_CP011410.1|WP_000199611.1|1261502_1263044_-|type-I-restriction-modification-system-subunit-M
MTSAQQRAALQRQIWQIANDVRGAVDGWDFKQYVLGTLFYRFISENFTNYMEGGDSSIQYSKLNDKKITKEIKDDAIKTRGYFIYPSQLFANIVTKADKNERLNTDLAGIFKDIESSANGFPSEHDIKGLFADFDTTSNRLGNTVKDKNSRLAAVLKRVAELDFGDFDSSHIDLFGDAYEFLISNYAANAGKSGGEFFTPQHVSKLIARLAIHKQTRINKIYDPACGSGSLLLQAKKQFDDHIIEEGFFGQEINHTTYNLARMNMFLHNINYDKFDIELGNTLIDPQHNHEKPFDAIVSNPPYSINWKGSDDPTLINDERFAPAGVLAPKSKADFAFVLHALSYLSSKGRAAIVCFPGIFYRSGAEQKIRQYLVGNNFVETVISLAPNLFFGTTIAVNILVLSKHKTDTNTQFIDASGLFKKETNNNILTEDHIERIMQTFDSKVDMEHFAKSVSVETIANNDYNLSVSSYVEAKDNREVIDIQKLNAELKTTVAKIDQLRADIDAIVAEIEG
>NZ_CP011410.1|WP_000061288.1|1259116_1260268_-|AAA-family-ATPase
MSMDIAKLLKDADQKVQLLYAFNGTGKTRLSREFKQLVAPKNNRDEADQAESSHNKILYYNAFTKNLFYWDNDLEKDAEPKLKIQSNSFTDWILKDQGQDRNIITNFQHYTNEKLTPRFNEAYTVKDKNEQEVIVKEFSEVTFSLTRGNEERSGNLKISKGEESNFIWSIFYSLLEQVISVLNVIDSSEQETDQFDQLEYVFIDDPVSSLDENHLIELAAELIQSSKSDIRFLITTHNPLFYNVLHNEFKKDTFKKYILKKQEDESYELANQSTDSPFSYHLHLKAELEKAIETGQLHKYHFNFLRNILEKTSTFVGLEKWEDLLPKTEDGDPNPYEVRIINFSSHSKHSDNEVVEVPDEHRRVLSFLVKKLDEMYRLRMRTK
>NZ_CP011410.1|WP_000141532.1|1256000_1259099_-|type-I-restriction-endonuclease-subunit-R
MTEYKTIAESNHFIVLDKYNREWQVSESYQSEADLEKELVQDLKNQGYEFRTDISTPEKMLANVREKLQALNAMQFSEGEWLRFVETWLDKPSDTVIDKTRKIHDDYIHDFVFDDGHIQNIYLLDKKNIARNKVEVIRQFEQAGTHSNRYDVTILVNGLPLVQIELKKRGVAIREAFNQIHRYSKESFNSEHSLFKYLQLFVISNGTDSRYFANTTHRNKNSFDFTMNWAKADNSLMKDLKDFTATFFQKNTLLNVLLTYSVFDVSDTLLVMRPYQIAATERILWKIKSSFGTKNWSKPESGGYIWHTTGSGKTLTSFKAARLSTELDFIDKVFFVVDRKDLDYQTMKEYQRFSPDSVNGSDSTAGLKRNLEMDDNKIIVTTIQKLNNLIKSESDLSIYNKQVVFIFDEAHRSQFGEAQKNLRKKFKKFYQFGFTGTPIFPQNALGADTTASVFGRELHSYVITDAIRDEKVLKFKVDYNDVRPKFKEIETEQDEKKLTAAENKQALLHEERIREISQYILNQFKQKTHRLQPSSKGFNAMFAVSSVDAAKLYYESFKEVQKDQDKPLKVATIFSFSANEEQDAVGEIQDESFEVSAMESTAKEFLSAAINDYNIMFQTNFGVDSNSFQNYYRDLAKKVKDREIDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLLQAYSRTNRIYDATKTFGNIITFRDLEKATIEAITLYGDKNTKNVVLEKSYKEYMEGFTDLATGEARRGYVDVVAELQQRFPKPEEIEKESDKKAFVKLFGEYLRVENVLQNYDEFTSLKALQNIDMSNQEAVEEFKAKHYVSDEGLAALQKIQVPAERKIQDYRSTYNDIRDWLRRQKSGDEKVKPRIDWDDVVFEVDLLKSQEINLDYILELIFEHNKKVKNKSILIEDIRRVIRASIGNRAKESLMIDFINQTDLDQISDKASVIDAFFSFAQTEQKREADELIQTENLNAEAAKRYITSSLRREFASENGTELNTILPKMSPLHPQYLTIKQSVFQKVSAFVEKFKGVGGQI
>NZ_CP011410.1|WP_029764174.1|1272988_1273180_+|hypothetical-protein
MSVFKGGEQVYRFLSLFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWPIIR
>NZ_CP011410.1|WP_000683530.1|1273296_1273581_-|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP011410.1|WP_000511226.1|1273580_1275206_-|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKAIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALIKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP011410.1|WP_082267386.1|1275684_1275894_-|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHRLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP011410.1|WP_000578381.1|1276424_1277300_-|PcfJ-domain-containing-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP011410.1|WP_000451411.1|1277561_1277774_+|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP011410.1|WP_001072141.1|1277957_1278344_-|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVLFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP011410.1|WP_001110344.1|1278686_1279238_-|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIEIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP011410.1|WP_000590873.1|1280341_1281838_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MIKISGLNKAFTTKVLFDDLNLSINRGEKVGLVGRNGHGKSTLFQVILGNVEADSGTISIPKGYKIGHLQQHLHFTKPTVREECSLGLPEGEEYETWKVEKILSGLGFSEQDMEKNPNEFSGGYQIRMNLAKLLVSSPDMLMLDEPNNYLDIVTIRWLEEFLREWEGEIILVTHDRGFMDAVVTHTIAIHRTKAIKVQGDTDKLYNQINQSEEIYEKTRLNEAKKRKQEEIFIAKFKAKASFASRAQSRVKKLEKQGEMKELEKIQDLELYFNSAPFNANQMLSAENLSFSYDGKEPFLIENFSISVGSRERICIIGKNGKGKSTLLKILAGELETSQGTIKKHPVLKEGYFGQTNKLNLNENSTVVEEIMISDPSCNEWKARTIAGGLMFSEDQALKKIKVLSGGEKSRVLLGKILVTPCHLLYLDEPTNHLDMQSCDSLIEAIDEFDGSVIMVTHDELHLRAVATKLIVFDNDSIQIFNGSYDDFLNDVGWSNEHY
>NZ_CP011410.1|WP_000841973.1|1282118_1283192_-|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGVGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM

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Crispr_ID: NZ_CP011410_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011410_3

1272004-1272468

Unclear

NA:I-A,I-B,II-B

Consensus_repeat	Method
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	CRISPRCasFinder
CGGCATCAAAGTTATATTCAGA	CRT
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	PILER-CR

6 spacers

cas6,cas8b3,cas7,cas5,cas2,cas1

The CRISPR arrays of NZ_CP011410_3

>merge|NZ_CP011410|3|1272004-1272468|CRISPRCasFinder,CRT,PILER-CR
GTCTAAATCGCCTACCGGCATCAAAGTTATATTCAGAATGGATGATCAAACAAAAAGGGACATAAACTAAGTGCTCAACGCCTACCGACATCAAAGTTATATTCAGACCGGCAAGGTAGACGAATTGTCAGACCCCGCAAAGTGCTCAACGCCTATCGGCATCAAAGTTATATTCAGGTTGAGAGTCTCCGTCAATAGTTTGTAGGTATCGGTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGACAAAAATGTAATTGCCACATTTTTGCTGTTTATTCGTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGACTTATCTTCTAAATTTGTAATATTCAAAAGTCCATGTGCTCAACACCTAACGGCATCAAAGTTATATTCAGATAGAATATTGAAATATTCTCATGTGATTTTTGAGGGTGCTCAACGCCTAACGGCATCCCGATTTTTGTAAGTT

>NZ_CP011410|3|3|1272004-1272468|CRISPRCasFinder
GTCTAAATCGCCTACCGGCATCAAAGTTATATTCAGA	ATGGATGATCAAACAAAAAGGGACATAAACTAA
GTGCTCAACGCCTACCGACATCAAAGTTATATTCAGA	CCGGCAAGGTAGACGAATTGTCAGACCCCGCAAA
GTGCTCAACGCCTATCGGCATCAAAGTTATATTCAGG	TTGAGAGTCTCCGTCAATAGTTTGTAGGTATCG
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	CAAAAATGTAATTGCCACATTTTTGCTGTTTATTC
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	CTTATCTTCTAAATTTGTAATATTCAAAAGTCCAT
GTGCTCAACACCTAACGGCATCAAAGTTATATTCAGA	TAGAATATTGAAATATTCTCATGTGATTTTTGAGG
GTGCTCAACGCCTAACGGCATCCCGATTTTTGTAAGTT

>NZ_CP011410|3|1|1272019-1272395|CRT
CGGCATCAAAGTTATATTCAGA	ATGGATGATCAAACAAAAAGGGACATAAACTAAGTGCTCAACGCCTAC
CGACATCAAAGTTATATTCAGA	CCGGCAAGGTAGACGAATTGTCAGACCCCGCAAAGTGCTCAACGCCTAT
CGGCATCAAAGTTATATTCAGG	TTGAGAGTCTCCGTCAATAGTTTGTAGGTATCGGTGCTCAACGCCTAA
CGGCATCAAAGTTATATTCAGA	CAAAAATGTAATTGCCACATTTTTGCTGTTTATTCGTGCTCAACGCCTAA
CGGCATCAAAGTTATATTCAGA	CTTATCTTCTAAATTTGTAATATTCAAAAGTCCATGTGCTCAACACCTAA
CGGCATCAAAGTTATATTCAGA

>NZ_CP011410|3|1|1272074-1272395|PILER-CR
GTGCTCAACGCCTACCGACATCAAAGTTATATTCAGA	CCGGCAAGGTAGACGAATTGTCAGACCCCGCAAA
GTGCTCAACGCCTATCGGCATCAAAGTTATATTCAGG	TTGAGAGTCTCCGTCAATAGTTTGTAGGTATCG
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	CAAAAATGTAATTGCCACATTTTTGCTGTTTATTC
GTGCTCAACGCCTAACGGCATCAAAGTTATATTCAGA	CTTATCTTCTAAATTTGTAATATTCAAAAGTCCAT
GTGCTCAACACCTAACGGCATCAAAGTTATATTCAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011410.1\|WP_000141532.1\|1256000_1259099_-\|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223683
NZ_CP011410.1\|WP_000683530.1\|1273296_1273581_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP011410.1\|WP_000511226.1\|1273580_1275206_-\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP011410.1\|WP_000533549.1\|1263218_1263401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_029764174.1\|1272988_1273180_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000841973.1\|1282118_1283192_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP011410.1\|WP_000199611.1\|1261502_1263044_-\|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl\|CDD\|211578
NZ_CP011410.1\|WP_000371341.1\|1265007_1265631_-\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP011410.1\|WP_000451411.1\|1277561_1277774_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_001072141.1\|1277957_1278344_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_001110344.1\|1278686_1279238_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000061288.1\|1259116_1260268_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|372509
NZ_CP011410.1\|WP_000236257.1\|1264288_1264621_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000590873.1\|1280341_1281838_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP011410.1\|WP_000052104.1\|1265651_1266491_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP011410.1\|WP_000026911.1\|1270739_1271372_-\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP011410.1\|WP_000098765.1\|1266555_1268439_-\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP011410.1\|WP_082267386.1\|1275684_1275894_-\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP011410.1\|WP_000578381.1\|1276424_1277300_-\|PcfJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP011410.1\|WP_001140542.1\|1263393_1263822_-\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269

Protein	Function_ID	Function_description	E-value
NZ_CP011410.1\|WP_000141532.1\|1256000_1259099_-\|type-I-restriction-endonuclease-subunit-R	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	0
NZ_CP011410.1\|WP_000683530.1\|1273296_1273581_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP011410.1\|WP_000511226.1\|1273580_1275206_-\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP011410.1\|WP_000841973.1\|1282118_1283192_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	8.59013e-27
NZ_CP011410.1\|WP_000199611.1\|1261502_1263044_-\|type-I-restriction-modification-system-subunit-M	gnl\|CDD\|211578	TIGR00497, hsdM, type I restriction system adenine methylase (hsdM). Function: methylation of specific adenine residues; required for both restriction and modification activities. The ECOR124/3 I enzyme recognizes 5'GAA(N7)RTCG. for E.coli see (J. Mol. Biol. 257: 960-969 (1996)). [DNA metabolism, Restriction/modification].	0
NZ_CP011410.1\|WP_000371341.1\|1265007_1265631_-\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	9.87123e-100
NZ_CP011410.1\|WP_000590873.1\|1280341_1281838_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	2.21093e-156
NZ_CP011410.1\|WP_000061288.1\|1259116_1260268_-\|AAA-family-ATPase	gnl\|CDD\|372509	pfam13166, AAA_13, AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.	7.75223e-07
NZ_CP011410.1\|WP_000052104.1\|1265651_1266491_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	9.32745e-84
NZ_CP011410.1\|WP_000026911.1\|1270739_1271372_-\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	6.95928e-102
NZ_CP011410.1\|WP_000098765.1\|1266555_1268439_-\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	6.46036e-165
NZ_CP011410.1\|WP_082267386.1\|1275684_1275894_-\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.92572e-10
NZ_CP011410.1\|WP_000578381.1\|1276424_1277300_-\|PcfJ-domain-containing-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP011410.1\|WP_001140542.1\|1263393_1263822_-\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15

>NZ_CP011410.1|WP_000026911.1|1270739_1271372_-|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPTLHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP011410.1|WP_000098765.1|1266555_1268439_-|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLSECTSPLLRAGLAGLYSTLYSLENEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRTKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKKSRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP011410.1|WP_000052104.1|1265651_1266491_-|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFPGIKAAVEDAKKRIGKSA
>NZ_CP011410.1|WP_000371341.1|1265007_1265631_-|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSGRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDINSSSLTSKMRFSFQSAEGIPENAWFKLRPS
>NZ_CP011410.1|WP_000236257.1|1264288_1264621_+|hypothetical-protein
MVINARKKSKRRFQLKQAQPFLSSQDIFCEGMTIKSGETGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDINVWLFAFWRELSPNGIKVIFRQWPLYCVLNA
>NZ_CP011410.1|WP_001140542.1|1263393_1263822_-|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP011410.1|WP_000533549.1|1263218_1263401_+|hypothetical-protein
MGRRGKIATEHNASEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK
>NZ_CP011410.1|WP_000199611.1|1261502_1263044_-|type-I-restriction-modification-system-subunit-M
MTSAQQRAALQRQIWQIANDVRGAVDGWDFKQYVLGTLFYRFISENFTNYMEGGDSSIQYSKLNDKKITKEIKDDAIKTRGYFIYPSQLFANIVTKADKNERLNTDLAGIFKDIESSANGFPSEHDIKGLFADFDTTSNRLGNTVKDKNSRLAAVLKRVAELDFGDFDSSHIDLFGDAYEFLISNYAANAGKSGGEFFTPQHVSKLIARLAIHKQTRINKIYDPACGSGSLLLQAKKQFDDHIIEEGFFGQEINHTTYNLARMNMFLHNINYDKFDIELGNTLIDPQHNHEKPFDAIVSNPPYSINWKGSDDPTLINDERFAPAGVLAPKSKADFAFVLHALSYLSSKGRAAIVCFPGIFYRSGAEQKIRQYLVGNNFVETVISLAPNLFFGTTIAVNILVLSKHKTDTNTQFIDASGLFKKETNNNILTEDHIERIMQTFDSKVDMEHFAKSVSVETIANNDYNLSVSSYVEAKDNREVIDIQKLNAELKTTVAKIDQLRADIDAIVAEIEG
>NZ_CP011410.1|WP_000061288.1|1259116_1260268_-|AAA-family-ATPase
MSMDIAKLLKDADQKVQLLYAFNGTGKTRLSREFKQLVAPKNNRDEADQAESSHNKILYYNAFTKNLFYWDNDLEKDAEPKLKIQSNSFTDWILKDQGQDRNIITNFQHYTNEKLTPRFNEAYTVKDKNEQEVIVKEFSEVTFSLTRGNEERSGNLKISKGEESNFIWSIFYSLLEQVISVLNVIDSSEQETDQFDQLEYVFIDDPVSSLDENHLIELAAELIQSSKSDIRFLITTHNPLFYNVLHNEFKKDTFKKYILKKQEDESYELANQSTDSPFSYHLHLKAELEKAIETGQLHKYHFNFLRNILEKTSTFVGLEKWEDLLPKTEDGDPNPYEVRIINFSSHSKHSDNEVVEVPDEHRRVLSFLVKKLDEMYRLRMRTK
>NZ_CP011410.1|WP_000141532.1|1256000_1259099_-|type-I-restriction-endonuclease-subunit-R
MTEYKTIAESNHFIVLDKYNREWQVSESYQSEADLEKELVQDLKNQGYEFRTDISTPEKMLANVREKLQALNAMQFSEGEWLRFVETWLDKPSDTVIDKTRKIHDDYIHDFVFDDGHIQNIYLLDKKNIARNKVEVIRQFEQAGTHSNRYDVTILVNGLPLVQIELKKRGVAIREAFNQIHRYSKESFNSEHSLFKYLQLFVISNGTDSRYFANTTHRNKNSFDFTMNWAKADNSLMKDLKDFTATFFQKNTLLNVLLTYSVFDVSDTLLVMRPYQIAATERILWKIKSSFGTKNWSKPESGGYIWHTTGSGKTLTSFKAARLSTELDFIDKVFFVVDRKDLDYQTMKEYQRFSPDSVNGSDSTAGLKRNLEMDDNKIIVTTIQKLNNLIKSESDLSIYNKQVVFIFDEAHRSQFGEAQKNLRKKFKKFYQFGFTGTPIFPQNALGADTTASVFGRELHSYVITDAIRDEKVLKFKVDYNDVRPKFKEIETEQDEKKLTAAENKQALLHEERIREISQYILNQFKQKTHRLQPSSKGFNAMFAVSSVDAAKLYYESFKEVQKDQDKPLKVATIFSFSANEEQDAVGEIQDESFEVSAMESTAKEFLSAAINDYNIMFQTNFGVDSNSFQNYYRDLAKKVKDREIDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLLQAYSRTNRIYDATKTFGNIITFRDLEKATIEAITLYGDKNTKNVVLEKSYKEYMEGFTDLATGEARRGYVDVVAELQQRFPKPEEIEKESDKKAFVKLFGEYLRVENVLQNYDEFTSLKALQNIDMSNQEAVEEFKAKHYVSDEGLAALQKIQVPAERKIQDYRSTYNDIRDWLRRQKSGDEKVKPRIDWDDVVFEVDLLKSQEINLDYILELIFEHNKKVKNKSILIEDIRRVIRASIGNRAKESLMIDFINQTDLDQISDKASVIDAFFSFAQTEQKREADELIQTENLNAEAAKRYITSSLRREFASENGTELNTILPKMSPLHPQYLTIKQSVFQKVSAFVEKFKGVGGQI
>NZ_CP011410.1|WP_029764174.1|1272988_1273180_+|hypothetical-protein
MSVFKGGEQVYRFLSLFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWPIIR
>NZ_CP011410.1|WP_000683530.1|1273296_1273581_-|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP011410.1|WP_000511226.1|1273580_1275206_-|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKAIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALIKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP011410.1|WP_082267386.1|1275684_1275894_-|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHRLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP011410.1|WP_000578381.1|1276424_1277300_-|PcfJ-domain-containing-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP011410.1|WP_000451411.1|1277561_1277774_+|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP011410.1|WP_001072141.1|1277957_1278344_-|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVLFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP011410.1|WP_001110344.1|1278686_1279238_-|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIEIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP011410.1|WP_000590873.1|1280341_1281838_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MIKISGLNKAFTTKVLFDDLNLSINRGEKVGLVGRNGHGKSTLFQVILGNVEADSGTISIPKGYKIGHLQQHLHFTKPTVREECSLGLPEGEEYETWKVEKILSGLGFSEQDMEKNPNEFSGGYQIRMNLAKLLVSSPDMLMLDEPNNYLDIVTIRWLEEFLREWEGEIILVTHDRGFMDAVVTHTIAIHRTKAIKVQGDTDKLYNQINQSEEIYEKTRLNEAKKRKQEEIFIAKFKAKASFASRAQSRVKKLEKQGEMKELEKIQDLELYFNSAPFNANQMLSAENLSFSYDGKEPFLIENFSISVGSRERICIIGKNGKGKSTLLKILAGELETSQGTIKKHPVLKEGYFGQTNKLNLNENSTVVEEIMISDPSCNEWKARTIAGGLMFSEDQALKKIKVLSGGEKSRVLLGKILVTPCHLLYLDEPTNHLDMQSCDSLIEAIDEFDGSVIMVTHDELHLRAVATKLIVFDNDSIQIFNGSYDDFLNDVGWSNEHY
>NZ_CP011410.1|WP_000841973.1|1282118_1283192_-|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGVGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM

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Crispr_ID: NZ_CP011410_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011410_5

1494008-1494451

Orphan

Consensus_repeat	Method
TTCCTAAAGAAATCGGAAAACTAC	CRISPRCasFinder

6 spacers

The CRISPR arrays of NZ_CP011410_5

>merge|NZ_CP011410|5|1494008-1494451|CRISPRCasFinder
TTCCGAGACAAATCGGAAATCTACAAAATTTAACAGAGTTGAATTTAGGGAGCAATTCACTTACGACAGTTCCTAAAGAAATCGGTTGGCTACGCAACTTACAAAGTTTGTGGTTGTTTGGAAACTGGCTAGCAACCCTTCCTGAAGAAGTCGGGGAACTTCACAATTTAGAAGAGCTAAGTTTAAGCAGGAACCTTCTCATTACACTTCCAAAAGAAATCAGGCGGCTACAAAATTTACAAGTATTGAATCTATCTGACAATCGTCCCACTTTCACCGTTCTTCCAAAAGAAATCGGAGAACTACGGAATTTAAAAGAGTTGAATTTAGAGAACAATTCACTTACGACAATTCCTAAAGAAATCGGAAAACTACAAAATTTAAAATGGTTGCGTTTAGGGAGCAATTCACTTACGACGCTTCCAAAAGAAATCGGAAAACTAC

>NZ_CP011410|5|5|1494008-1494451|CRISPRCasFinder
TTCCGAGACAAATCGGAAATCTAC	AAAATTTAACAGAGTTGAATTTAGGGAGCAATTCACTTACGACAG
TTCCTAAAGAAATCGGTTGGCTAC	GCAACTTACAAAGTTTGTGGTTGTTTGGAAACTGGCTAGCAACCC
TTCCTGAAGAAGTCGGGGAACTTC	ACAATTTAGAAGAGCTAAGTTTAAGCAGGAACCTTCTCATTACAC
TTCCAAAAGAAATCAGGCGGCTAC	AAAATTTACAAGTATTGAATCTATCTGACAATCGTCCCACTTTCACCGTTC
TTCCAAAAGAAATCGGAGAACTAC	GGAATTTAAAAGAGTTGAATTTAGAGAACAATTCACTTACGACAA
TTCCTAAAGAAATCGGAAAACTAC	AAAATTTAAAATGGTTGCGTTTAGGGAGCAATTCACTTACGACGC
TTCCAAAAGAAATCGGAAAACTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011410.1\|WP_000790894.1\|1488348_1489737_-\|CHASE3-domain-containing-protein	unknown	unknown	gnl\|CDD\|226702
NZ_CP011410.1\|WP_000133081.1\|1502287_1503484_+\|LCP-family-protein	unknown	unknown	gnl\|CDD\|379163
NZ_CP011410.1\|WP_000872130.1\|1490368_1490560_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000392265.1\|1484759_1485467_+\|lysophospholipid-acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|153245
NZ_CP011410.1\|WP_000053900.1\|1484215_1484425_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000942239.1\|1494648_1494828_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000347004.1\|1481844_1482774_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP011410.1\|WP_047020766.1\|1499047_1499677_+\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|293786
NZ_CP011410.1\|WP_000402846.1\|1490619_1491483_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|372616
NZ_CP011410.1\|WP_000779367.1\|1501598_1502114_+\|MepB-family-protein	unknown	unknown	gnl\|CDD\|378077
NZ_CP011410.1\|WP_001250026.1\|1491569_1492598_+\|CapA-family-protein	unknown	unknown	gnl\|CDD\|277327
NZ_CP011410.1\|WP_047020765.1\|1495146_1497258_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP011410.1\|WP_001206642.1\|1480047_1481115_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP011410.1\|WP_000445511.1\|1483082_1483949_-\|bile-acid:sodium-symporter-family-protein	unknown	unknown	gnl\|CDD\|223462
NZ_CP011410.1\|WP_000282526.1\|1487900_1488356_-\|response-regulator	unknown	unknown	gnl\|CDD\|381108
NZ_CP011410.1\|WP_001259333.1\|1497259_1498423_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271320
NZ_CP011410.1\|WP_001070122.1\|1503490_1503862_+\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|376779
NZ_CP011410.1\|WP_000577059.1\|1503896_1505429_+\|MBOAT-family-protein	unknown	unknown	gnl\|CDD\|224610
NZ_CP011410.1\|WP_000011183.1\|1505406_1506612_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369442
NZ_CP011410.1\|WP_000447937.1\|1500154_1500607_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176856

Protein	Function_ID	Function_description	E-value
NZ_CP011410.1\|WP_000790894.1\|1488348_1489737_-\|CHASE3-domain-containing-protein	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	2.12446e-63
NZ_CP011410.1\|WP_000133081.1\|1502287_1503484_+\|LCP-family-protein	gnl\|CDD\|379163	pfam13399, LytR_C, LytR cell envelope-related transcriptional attenuator. This family appears at the C-terminus of members of the LytR_cpsA_psr, pfam03816, family.	8.82019e-09
NZ_CP011410.1\|WP_000392265.1\|1484759_1485467_+\|lysophospholipid-acyltransferase-family-protein	gnl\|CDD\|153245	cd07983, LPLAT_DUF374-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are the uncharacterized DUF374 phospholipid/glycerol acyltransferases and similar proteins.	3.28116e-81
NZ_CP011410.1\|WP_000447937.1\|1500154_1500607_+\|hypothetical-protein	gnl\|CDD\|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	0.000144073
NZ_CP011410.1\|WP_000347004.1\|1481844_1482774_-\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	4.50203e-18
NZ_CP011410.1\|WP_047020766.1\|1499047_1499677_+\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	1.69576e-20
NZ_CP011410.1\|WP_000402846.1\|1490619_1491483_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.26219e-23
NZ_CP011410.1\|WP_000779367.1\|1501598_1502114_+\|MepB-family-protein	gnl\|CDD\|378077	pfam08877, MepB, MepB protein. MepB is a functionally uncharacterized protein in the mepRAB gene cluster of Staphylococcus aureus.	6.44519e-70
NZ_CP011410.1\|WP_001250026.1\|1491569_1492598_+\|CapA-family-protein	gnl\|CDD\|277327	cd07381, MPP_CapA, CapA and related proteins, metallophosphatase domain. CapA is one of three membrane-associated enzymes in Bacillus anthracis that is required for synthesis of gamma-polyglutamic acid (PGA), a major component of the bacterial capsule. The YwtB and PgsA proteins of Bacillus subtilis are closely related to CapA and are also included in this alignment model. CapA belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.35279e-78
NZ_CP011410.1\|WP_047020765.1\|1495146_1497258_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.49178e-57
NZ_CP011410.1\|WP_001206642.1\|1480047_1481115_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	1.06403e-39
NZ_CP011410.1\|WP_000445511.1\|1483082_1483949_-\|bile-acid:sodium-symporter-family-protein	gnl\|CDD\|223462	COG0385, COG0385, Predicted Na+-dependent transporter [General function prediction only].	3.94598e-61
NZ_CP011410.1\|WP_000282526.1\|1487900_1488356_-\|response-regulator	gnl\|CDD\|381108	cd17557, REC_Rcp-like, phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains. This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.20697e-60
NZ_CP011410.1\|WP_001259333.1\|1497259_1498423_+\|hypothetical-protein	gnl\|CDD\|271320	cd05819, NHL, NHL repeat unit of beta-propeller proteins. The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.	0.00156165
NZ_CP011410.1\|WP_000577059.1\|1503896_1505429_+\|MBOAT-family-protein	gnl\|CDD\|224610	COG1696, DltB, Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane].	3.4245e-54
NZ_CP011410.1\|WP_000011183.1\|1505406_1506612_+\|hypothetical-protein	gnl\|CDD\|369442	pfam07611, DUF1574, Protein of unknown function (DUF1574). A family of hypothetical proteins in Leptospira interrogans.	0.00170966
NZ_CP011410.1\|WP_001070122.1\|1503490_1503862_+\|ribosome-silencing-factor	gnl\|CDD\|376779	pfam02410, RsfS, Ribosomal silencing factor during starvation. This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits. This family is structurally homologous to nucleotidyltransferases.	8.24928e-35

>NZ_CP011410.1|WP_001250026.1|1491569_1492598_+|CapA-family-protein
MRQTFILSVLFLFSFGLLGDSKTIKIKAVGDMVPGTNFPQPLNIQDPRSFLFGKVESYLKGADLLFGNFESTLTDYPNTSKDTSRKMIFAFRTPPAYAKVLKEVGFDILSIANNHSLDFHEQGFVDTQKNLSDVGIRYTGKKGMITYMNVKDISVAWIGFSHLKSHNNVNEIGEGVALVKEAKKKAQLVFISFHGGAEGGPALHVKNQMERFYGEYRGNLVEFSHSLIDAGADLVIGHGPHLVRAMELYKGRLIAYSLGNFMGYRALSSRGIVGYSLVLEVEVDSQGKFVKGKILPLQLDSASIPEYDPEKKTIDLMKKLTKEDFPGKGPKIADDGTILPGT
>NZ_CP011410.1|WP_000402846.1|1490619_1491483_-|class-I-SAM-dependent-methyltransferase
MEIIPCNTCGSSEFKPLFSKSNHKNELFHIVQCIRCSLVQVSPQPSPKEVASYYSEEYFLKRSDRGYDNYFSEGIRNEISRVFGLNLKDLDFQTWEKSLSTTKRCLDVGCAAGYFVDYMQSRGWDSYGMDIAQAPVKFARDKLKLKVEQVDFLEWKPTNVDQFDLITLWASIEHLHKPKETLEKIYTHLKPGGRVILSTCRWGILAKLQGPSWRYLNVPEHLYYYSLPGIVKLCRSLGFQKKKHITYGSGLTAKKNSSLLYKTLKYFADPTVKFLDQGDMMALCFSK
>NZ_CP011410.1|WP_000872130.1|1490368_1490560_+|hypothetical-protein
MKWSIEAGLLVVAMEFLNNSIQVSHISVLGDFYKIDYRYNFYRKTLFQCKILALNSSEYNFEI
>NZ_CP011410.1|WP_000790894.1|1488348_1489737_-|CHASE3-domain-containing-protein
MKNKIEKNIVYGLIVILFLNLIMTGSAYYTLQQSLELRKWETHTQEVLLNLEETLSSFRETHSVLRAYILYRDKELIDSYFKNKRIVLEKIQELRNKTVDNPVEQKRLLNIESNLKEKFSYMEDILLIKKYKSFQDYVELYRSPNGFTLSEKIKFLLQEIKDEELRLLNIRKHNSKINMTISVTLLFSGIVLNLSFILLQNWLIYKESQRRLKTEEILEKSNQHLKLYSEQLERSNRDLEAFSYSVSHDLRSPIRGILGFSKILLEDHGAELREDSRRIVNIIIRNSENMGKLIDDLLEYSRLGRREPMFSVVNMKVLVEKVIEEVISYYPDMKAEISVAELPYANADTSLLKQLLFNLISNAFKYSQKKEIPKIEIGSYQNGEETVFFVKDNGAGFDMKYQHKLFNIFQRLHHTDQFEGTGVGLAIVKRVIERHNGRVWGKGNLNEGACFYFTLGVNDKNV
>NZ_CP011410.1|WP_000282526.1|1487900_1488356_-|response-regulator
MYNLQDELIEILYAEDNPQDSELTLRSLKKHKLTDQVKHVRDGEEALEYLYATGRYANRDKTRVPSLILLDLKMPKVDGIEVLRRVRNEENTKMLPVVILTSSAEEKDIIESYKLGVNSYVVKPFEFDKFGEVASEIGFYWVLINQSVSRT
>NZ_CP011410.1|WP_000392265.1|1484759_1485467_+|lysophospholipid-acyltransferase-family-protein
MEENSESHKGKKRSFKRKFLIWLIPFFVVNLQRLIGLTSRRINIGDESIRKIRKEKKPYILSGWHTNVLYSPYLNRNERMAVLISESKDGDFINQVVHRFGNYSIRGSSSKGGSKALKALIVHLKKNFPAAITPDGPRGPALVVQPGLIAAAQVSQVPIVSFHYECTRQWIAEKTWDKHRIPKPFTTFVVSYGEPIYIPRNLDEKGFEEARLMVEKAMLENRQKSIDKAEELRKK
>NZ_CP011410.1|WP_000053900.1|1484215_1484425_+|hypothetical-protein
MSLKNSEGIGAKSAPDLPKFYYTEFTKLELFKNESSISVFWKRSIESLPLSTTLLLKCKLLNSISVLSF
>NZ_CP011410.1|WP_000445511.1|1483082_1483949_-|bile-acid:sodium-symporter-family-protein
MESNLLTTVFLPIALGIIMLGMGMSLTVEDFKRIFVLPKAVITGLILQLFLLPLTGWFIANVFKLPSELSVGLMILAICPGGATSNLITHLAKGDVALSITLTAITSCITVLSIPFLLNISMHHFLGSGQMIKLNIPQTILQIFMITVLPVSIGMILNSKKPELSRKFEKTVKVLSGIFLVLIILGAIVRERQNIIPYFIQVGPASLALNLITMFLGYLGATLMKVTHPQRTSITIEVGIQNGTLGITIASAILNNPTMAIPSAIYSLIMFATGAIFSIWTNKSSNPT
>NZ_CP011410.1|WP_000347004.1|1481844_1482774_-|EamA-family-transporter
MDFMEVSESKWKPFLGTCIVLIGAIFFSAKAIFVKLVYRYDIDSITALTLRMLFAIPFFAWIAFRSKNTKTSVNLTKKDWGLIFILGFLGFYLASLFDFIGLEYISAGLERLTLFVYPTIVLIIGSFLFKRKIKKAEVFAIFLTYSGILVAFIGDIQTEGPNATKGVLFVLASAISYSLYLVGSESLIPKLGSVRFTSYLMLISGLIVVIHFFIVRNPKNLIQPPNVYLYGLALGILTTVIPAYLTTEGIRMIGSGRAAIIGSTGPISTILLAWIFLEEPITSSGIAGTILVLTGVLWIGRKKTDLKND
>NZ_CP011410.1|WP_001206642.1|1480047_1481115_+|AI-2E-family-transporter
MREGERRELSEYFIRTSFFLIVIFTIVVSLWGLHLLAVPIVMAFLIFYAFNGAINNLESLGVPRILSIAILMFVISVPIYFFINSIAPPIVSTLNPLLKNWKQDLDDAKFKYLTVTVNLQFNEFPSSWNETIRPDELIKKIAELMHEQVKAFVSYIPTLIGYLIITPLFAFLFLLNGNGMYKSLISLIPNRYFEMALMVTYKINEQLTNYLKSLMIQGAIICVVSGIGFYFIGLPYFYIFGLFLGVANSVPYLGPIMGAIPPLFFALVIGGDGTTELLTSILIVVAVAQMIDNFLIQPIIISGSVSLHPIVVVGAVTVGGAALGLVGMLIAVPIAAILKVTIQTLYSSMKDHNLL
>NZ_CP011410.1|WP_000942239.1|1494648_1494828_+|hypothetical-protein
MLQVAVKRAAFNSVSKVEFKNGFLSSFEVSKPGFNKIIFYLQTCPIHYSVSRRIFPFLQ
>NZ_CP011410.1|WP_047020765.1|1495146_1497258_+|TonB-dependent-receptor
MGKNQYIQILKYSVISFLLVFALTLSAQNQVPATKAETVQVIGKVPDSSSQNFRSNPSGFQTAIKLDETSARYTSLPEVLEREAGLRVRSFGGLGSYSTLSIRGTNPNQSRIYLDGIPLNNSQGGEVNLADLPFDSLESVEVYRSGNPIGFSGSAIGGSVNLVTKKDSQKPKTRINLGGGSFNTGKASVSHTGNYKGIGTSFLALGEKSDQNFSYKNDHGTVVLNTLDDTIDRRKNASFERAALFGSLKYQIGKTELKFLNDFNHRIHGLPGPGSNQTDRVHRKYDRNTSSFATDTKGLFVDSFRLETRGFYTAAKDDLYDPLSEFSKGTPNSRAEIRQAGFQVMPTLYLTDYHQILRGFVSLEKESFDRERLTSSNVVGRVEPKKERTYSSFRLEDEIRIWNSKILLIPSVTWDHYKDRFPSEEPWYRRQDPLSGDIKKTTFTNPKLGFVWKIFEKESWDVQFQANISKQYRIPSFLEMFGEQGSIVANPNLKPEQSENGDAGFIYKTNHSFLKTKTSISYFKKDMRDMILFLPNSQFTLRPENVDSAKIRGLEFSHRGDWKYGIKFLFNYTYQEAINTSSSPYLHGKILPLRPRHEFSSTFSWKGKKLETGIELLYIGAVFRDRTNEYINYIPERQIWNYFFTWVIDSESKDSDLNGNSKEITREVLLTFEVKNFTDKRISDLIGYPLPGRSWYTTLSMRF
>NZ_CP011410.1|WP_001259333.1|1497259_1498423_+|hypothetical-protein
MRTKLKVFILFFFLNVFCRDIERPSFLSLLLIQNLPGNIGVVTTDFGGGGRFKVINPTLFYAYPGLTPIHSDAVARFGNGKVYVLNRLNRDSIQVLDPNYGFITTSELSLGSKVNPVDMEFASASKAYVSLYGSNRLMIIDPTYMTITGFIDLGSYAESFSLGASPDGIPEMNGLKIVGDSLFVCLQRLDRNDPSGYFPPNTSSILLELNISTDQVVGTYTFPSSNPVGKPQLVELFGESHLVIATPARMGFQSQIDGGVSAFRLSTRTFVSRFLYSEAIAGGDILSVQIKSDTMGYVAVLDSGFTKTLQAFNPSTGEKISTLLTIPTSYDASLSSVLLASDQILYVGNTQFQQPGVTMFDTERGNRLLTPTPISVDLQPYDIIELK
>NZ_CP011410.1|WP_047020766.1|1499047_1499677_+|ankyrin-repeat-domain-containing-protein
MQEIFQAIASGQKAKVIGLLKRDPNLFQSLTEEGITPVLFSLYYGKLDISKEIYEISPSRNLFEAVALGDLEETKRLISKSTDVVNFLSADGWSALHLASYFGHLEIAKFLIFSGADLSLTSKSKLSYGNTALHSAVATGKKEADSNSLQNPGEITPLHIAASRSGSVDIIRLLLKKGADKKLISSEGQTPYTIAFEKGNMTEAKLLEV
>NZ_CP011410.1|WP_000447937.1|1500154_1500607_+|hypothetical-protein
METIRFSILIDADVKTVWHKMLEDSSYRIWAKEFHEGSYFEGSWEKESEIRFLAQDENDKPQGMYAKIRENIPYQFISIEHIGLISGGVIDTESEEVKKWTPAFENYTFQEESNGKTKLIIEMQTIEEYKSMFEEMWPKALKSLKELCEK
>NZ_CP011410.1|WP_000779367.1|1501598_1502114_+|MepB-family-protein
MKLTRTELIKILDNFQENVLKPCDVSMGSLFFEKEGSDYGACNFELKKWKITFRVAKITPKKVGQFVTLWKRNIQGQIQPYDIQDGTDYFIIYIYDKNRTGQFIFTKDVLLQQGILNGNGEGKLGFRVYPSWDVPYNQQAKKTQKWQLEYFLENLKKDSNQEDRVKHFLKL
>NZ_CP011410.1|WP_000133081.1|1502287_1503484_+|LCP-family-protein
MTDWFCRLEWNWDGASLESKESSKKKSGWLLYIAAGILLFSALIFLISKFNRTGLEEKIAAGKPIYFLFHAVNDSQEYEFGLLATLFPSNNRCALYFIHPITSFDDPDDSLDLLKSGAKSSVKSAITDLIDTKPNYTISISSSQWIRIVDLLGGLDVYTDNKTVRSSSEYNREPGVYTMSGQDVYDYTSKIDKKETLDYLERISRQESVVLTLYEALSQKKEFLTTPLLIFAHSLIESDLSKEDFVSLIKFVNSRRIQFGISELPGEPMNDPKTKKLYLKTDIARARIAFRKFSKDMNSDVFTDAEFARTEVLNGTEVAGLAKDVRGILSDKRIKVLAADNAWKKGFPKTVVIDRSGNTAIMDRISTVLEKAEVHHVLRKDLGLDATVVVGSDYEPRK
>NZ_CP011410.1|WP_001070122.1|1503490_1503862_+|ribosome-silencing-factor
MNPTHKQNPSTEDILRIIRDIMTDKKCEEVSILNLESVNSYLSYFVICTVNSAVQANAVAREVRKTLKEYKLSHKETDKTGTSATSGWTLLDFGEIIVHIMTPEKREYYNLDRLWRDAKRIEL
>NZ_CP011410.1|WP_000577059.1|1503896_1505429_+|MBOAT-family-protein
MIFNSAVFIYFFLVVLAVCYFFAVRKTSRTIQNLFLLIASYIFYGWWDWIFLILIVFVSVSNFYIALLMEQKESIRGHLLFVAVVIDMGILGFFKYYNFFIENLSTILKTSAVFLGAQNSTLFRDDIFLQIILPVGISFFTFQTLSYVIDVYFRKLKAETNLMDFCLFVCFFPQLVAGPIERAGDLLPQIKKDRKIDLDLFYKGCLLILVGYYMKTYVADNLAELADLVLLENFGLYKSNPELAGGHSAIHTVLALCAFIFQIYCDFAGYSYIARGCAFLLGFHLSENFITPEFSVNFRELFRRWHVTLNRWFTDYVYIPLGGSKVSKFHNYRNLFIIFVLSGIWHGASWNFALWGLCCGFYIVLYMVFREPFEKLKIFVKFKFPFLNHPFFIKGFFFWSCFFTMFMFAMSSIFFRSYDGNHVKILFTNVVENFFILKGPNDQIGISNYFMEILKLIGPLLVWDYFHYKNNSAFFIFEKPVIVRVLTYLFFFYCIVLKGVFGKNVIYFAF
>NZ_CP011410.1|WP_000011183.1|1505406_1506612_+|hypothetical-protein
MSFTSLFKNKVVLILLIVLVLVELIAKFTEIYFYEHTEVFLVNNIRKKMESGVLDYKGLVFGDSRSMSLIPSRESKVYNFSLPAMGARYYSYYLKKYLDAGNQKPEFILFASSPGLISGGYGDPIVDPSLVKYVQPNMSLLEYLKNRFFAGLTYKNFVMDGVSTNARKTASEINWKFFSHRILHLFSIGEMFEQYKGPELVYVLSASVPNLFSTYRYRKALLNVFSYENYKTAEAVMKLDCGCEELYIPSCMPPESNFRDNRWIAEKLNFQNGGLNISDRIKPQHAILYQMSREKLKEETLAPYEAEPIFDFSAFEDFLKYAETKEIDVYYIVMPFPEYIEPTGYFSKFWNAFEPLKTKYPHLKVLKFEKQFMKPEYYSDQIHLNCQGAKLVNEMFYKLGY

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Crispr_ID: NZ_CP011410_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011410_7

1531045-1531141

Orphan

Consensus_repeat	Method
TTCCTAAAGAAATAGGGAATTTAAAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011410_7

>merge|NZ_CP011410|7|1531045-1531141|CRISPRCasFinder
TTCCCAAAGAGATAGGCAATTTGAAAAATTTACGTAATTTAGTTTTAGGCAGAAATCAACTTATATCGCTACTCCCTGAAATAGGAAATTTAAAAAA

>NZ_CP011410|7|7|1531045-1531141|CRISPRCasFinder
TTCCCAAAGAGATAGGCAATTTGAAAAA	TTTACGTAATTTAGTTTTAGGCAGAAATCAACTTATATCGC
TACTCCCTGAAATAGGAAATTTAAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011410.1\|WP_047020767.1\|1545473_1546688_+\|EAL-domain-containing-response-regulator	unknown	unknown	gnl\|CDD\|238923
NZ_CP011410.1\|WP_000041092.1\|1532854_1533847_-\|aldolase	unknown	unknown	gnl\|CDD\|225184
NZ_CP011410.1\|WP_000875151.1\|1527430_1528333_-\|SH3-domain-containing-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000004530.1\|1533986_1534922_-\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|173265
NZ_CP011410.1\|WP_000405898.1\|1517371_1519192_+\|translational-GTPase-TypA	unknown	unknown	gnl\|CDD\|224138
NZ_CP011410.1\|WP_000060053.1\|1535725_1536193_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000869776.1\|1522053_1523235_+\|DJ-1/PfpI-family-protein	unknown	unknown	gnl\|CDD\|153233
NZ_CP011410.1\|WP_000788714.1\|1525462_1526530_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NZ_CP011410.1\|WP_000826009.1\|1538491_1540783_+\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132844
NZ_CP011410.1\|WP_000808860.1\|1519915_1520098_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000691886.1\|1512870_1513728_+\|pirin-family-protein	unknown	unknown	gnl\|CDD\|224655
NZ_CP011410.1\|WP_000490509.1\|1543977_1545462_+\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|237425
NZ_CP011410.1\|WP_000642921.1\|1520488_1521700_+\|acyltransferase	unknown	unknown	gnl\|CDD\|224748
NZ_CP011410.1\|WP_001158185.1\|1524311_1525406_-\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223260
NZ_CP011410.1\|WP_001177543.1\|1540850_1543523_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|226702
NZ_CP011410.1\|WP_000642733.1\|1543526_1543985_+\|response-regulator	unknown	unknown	gnl\|CDD\|381108
NZ_CP011410.1\|WP_002097271.1\|1529958_1530441_+\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP011410.1\|WP_000068280.1\|1526734_1527199_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|317965
NZ_CP011410.1\|WP_001974549.1\|1536596_1537868_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NZ_CP011410.1\|WP_001974506.1\|1536189_1536594_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|334450

Protein	Function_ID	Function_description	E-value
NZ_CP011410.1\|WP_047020767.1\|1545473_1546688_+\|EAL-domain-containing-response-regulator	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.14379e-89
NZ_CP011410.1\|WP_000041092.1\|1532854_1533847_-\|aldolase	gnl\|CDD\|225184	COG2301, CitE, Citrate lyase beta subunit [Carbohydrate transport and metabolism].	2.80269e-30
NZ_CP011410.1\|WP_000004530.1\|1533986_1534922_-\|ornithine-carbamoyltransferase	gnl\|CDD\|173265	PRK14804, PRK14804, ornithine carbamoyltransferase; Provisional.	0
NZ_CP011410.1\|WP_000405898.1\|1517371_1519192_+\|translational-GTPase-TypA	gnl\|CDD\|224138	COG1217, TypA, Predicted membrane GTPase involved in stress response [Signal transduction mechanisms].	0
NZ_CP011410.1\|WP_000826009.1\|1538491_1540783_+\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132844	cd07205, Pat_PNPLA6_PNPLA7_NTE1_like, Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1. Patatin-like phospholipase domain containing protein 6 (PNPLA6) and protein 7 (PNPLA7) are included in this family. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. PNPLA7 is an insulin-regulated phospholipase that is homologus to Neuropathy Target Esterase (NTE or PNPLA6) and is also known as NTE-related esterase (NRE). Human NRE is predominantly expressed in prostate, white adipose, and pancreatic tissue. NRE hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid, but shows no lipase activity with substrates like triacylglycerols (TG), cholesteryl esters, retinyl esters (RE), phosphatidylcholine (PC), or monoacylglycerol (MG). This family includes subfamily of PNPLA6 (NTE) and PNPLA7 (NRE)-like phospholipases.	1.10439e-84
NZ_CP011410.1\|WP_000869776.1\|1522053_1523235_+\|DJ-1/PfpI-family-protein	gnl\|CDD\|153233	cd03139, GATase1_PfpI_2, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	2.76455e-29
NZ_CP011410.1\|WP_000788714.1\|1525462_1526530_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	2.21184e-17
NZ_CP011410.1\|WP_000691886.1\|1512870_1513728_+\|pirin-family-protein	gnl\|CDD\|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	3.37928e-71
NZ_CP011410.1\|WP_000490509.1\|1543977_1545462_+\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|237425	PRK13557, PRK13557, histidine kinase; Provisional.	1.2441e-48
NZ_CP011410.1\|WP_000642921.1\|1520488_1521700_+\|acyltransferase	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	1.15187e-34
NZ_CP011410.1\|WP_001158185.1\|1524311_1525406_-\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|223260	COG0182, COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis].	6.51899e-149
NZ_CP011410.1\|WP_001177543.1\|1540850_1543523_+\|PAS-domain-S-box-protein	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	2.00639e-57
NZ_CP011410.1\|WP_000642733.1\|1543526_1543985_+\|response-regulator	gnl\|CDD\|381108	cd17557, REC_Rcp-like, phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains. This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	4.74194e-67
NZ_CP011410.1\|WP_002097271.1\|1529958_1530441_+\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	2.58313e-15
NZ_CP011410.1\|WP_000068280.1\|1526734_1527199_+\|hypothetical-protein	gnl\|CDD\|317965	pfam15662, SPATA3, Spermatogenesis-associated protein 3 family. The SPATA3 family of proteins is expressed significantly in testis and faintly in epididymis in the ten tissues of testis, ovary, spleen, kidney, lung, heart, brain, epididymis, liver and skeletal muscle in mouse. Members are not expressed in the eight other tissues. This suggests that SPATA3 plays potential roles in spermatogenesis cell apoptosis or spermatogenesis.	0.00530056
NZ_CP011410.1\|WP_001974549.1\|1536596_1537868_+\|GAF-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	3.05827e-63
NZ_CP011410.1\|WP_001974506.1\|1536189_1536594_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|334450	pfam01243, Putative_PNPOx, Pyridoxamine 5'-phosphate oxidase. Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as yeast YLR456W and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.	4.13554e-11

>NZ_CP011410.1|WP_002097271.1|1529958_1530441_+|rhodanese-like-domain-containing-protein
MAKESDFVKTKRNPIPNRLIDYKKFQNIVNSSAEEREAKRLTEEEFLNMIQDKEVVLLDARSESRYKLRHIKGAVSLPFTEFTKESLAKVIPKINSKILMYCNNNFMGSPEAFASKAPAASLNLSTFISLKAYGYKNIYELGPLLSVDSTKFTFEGTEVQ
>NZ_CP011410.1|WP_000875151.1|1527430_1528333_-|SH3-domain-containing-protein
MKYILSSIGFVLFLIGNNLISAEIESCFTSYPEVVVRDSPNTSGKKVRIIKQSIPLKILERTSTLEEIKIRNRKVQSNWVKISDGWIFGGLIQCIPKIFFAHPISYHEEELPFSPSDSTNWIAIFLQQESYLRKQISIDLKREHDTVVDQNENIKTGYKVNVINNPIVLIKGITFKKGNFPAITKKVPLELEFGKSYHFNFEKDNYRITSKGKPTQSSGINGYQLILHKNNEEMIIDSRVYRTEKPILVFAGDIDGDGELDFIFDLKDHYNVSNEHLYISSEKINDFFIVPVAANWNTGC
>NZ_CP011410.1|WP_000068280.1|1526734_1527199_+|hypothetical-protein
MAQNKKSALFDILKREKLEKMLKRNSSSGQSQSNEKPQTSVSENVPEKSSTEKKEPQTSKIYKAIEDVKLDIRYYFLQDEYVEKLASIYIKNEGPLEKLGIDPKKYLEYARDSFDRYKQLDKKMPLEPMNKKSWDHVEKSLNELITKLLEKFSK
>NZ_CP011410.1|WP_000788714.1|1525462_1526530_+|rhomboid-family-intramembrane-serine-protease
MKNHSPSPGECGNPGQICPGLALLDSLTTIRILSNMAKRKYRNGISLFGYSIFHPINLILIVNVLVYILQLFAGGTGIIEYYFALTPFRVFHGHYWQVFSYGFLHEAYGIPFIHLFFNMYVFVMFGGLICRYVSAWKFTVVYLTAILTGGITVLLAPVLNEILGIHYPMDLFQTTTLGASGGVTGILVLFGILFPETEVFLVFFRMKARYAAWIFVGGGFVADFVAVYYFHSPFVVSNSCHLGGAIGATLVAPLILKNNFGKIFPKNKDSENTKPTRSLNEDLDFQTQKNLKLLDELSKKISYSDQEDILIPLQQTNVNLCPPPTFQPEDPFCLRCDWLPNCALRKLKTSSEKTP
>NZ_CP011410.1|WP_001158185.1|1524311_1525406_-|S-methyl-5-thioribose-1-phosphate-isomerase
MQESGLKPILWKNKELILLDQRVLPGTTSYITAKTLEDCIFAIREMVVRGAPAIAITGAFGITLYWNSLVSKPSFSELKLKLSELLESRPTAVNLRLAIEEFSSRFPESNYSSFSLEEIQKGAEELALFMLSEDLENNLTLSKYALSLFPKQPSSLNIITHCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELQEEKIQSFLITDNMAGWVMSSRKIDAVIVGADRIASNGDTANKIGTYPLAIVAKHHGVPFYVAATAKSMDFRIPNGSYIPIEMRKEEEITSFGFLKDSDGKPLLKEGVIAPKGMKALNPSFDVTPASLITGIITEKGIVSPVTEENLKKIFQSI
>NZ_CP011410.1|WP_000869776.1|1522053_1523235_+|DJ-1/PfpI-family-protein
MKVVQIKLSFISRKFQKYSKIIMLILICFMCVLYDSLSGETKKPAYSTEDLSKSQYKSEKIPVYQNRFGRTRPVIAVIGDNYMTELTDYVVPYGVLTRSKSAEVFAVGISLTPISFYPALKIFPQESISSFDKKFSTGADYVIVPAIHHSENPILLEWLNLQASRGATIIGVCDGVWVLANAGLLKGKRATGFWYSLDDLEKKFKDTTWVRNRRYVVDQGIVTTTAVTASIPVSLALVEAIAGKDRAFNVAVELGVQDWSPVHDSNRFRLTMSSVYTVVSNFLSFWSYEKIGIPVMAGVDEIKLALVADAYSRTYRSQAFSIAKSEETIRTSNGLRLIPDIVFGSTTSLSRILPVFDSTPAVITLDQTLLKIGEIYGRSTADFVALILEYPYF
>NZ_CP011410.1|WP_000642921.1|1520488_1521700_+|acyltransferase
MKAFIKGLWYHREDEIQSLNGLRAFAIILVILNHYALVWKKPGTFQSDSLFWSGVDLSFVLSGFLISKSLLSDWTRNATIDFKKFYLKRTLRIFPAYYVFITFSWVASKLTLKIAEAKGLEKEAYYFSFKLSDAWGDFVFLGNYFPGINIHTWSLSIEEQFYLIFPLFCSLILFKMSSKYRQLLLWSLLLVPTISRVIVYMTTPLPLTPEYFNEIYFPFHTRFDSLVIGVIVMDLYMNQKGLINRLKTNPILYYLLLFLFFSFLCISHWANINMESFFTHTFKYNLLNIGFAGILLCAVVRSEGLLGRFLSLKIFVPIARLSFTIYLWHLVLIAVSVSILKIRTEPSSMFELLFQFIFVLTLMILLSVPFYLLFEYPFQYLRTRILPKRRSHKQLLSVQPKSF
>NZ_CP011410.1|WP_000808860.1|1519915_1520098_+|hypothetical-protein
MKQFRFFVIAFFLKKFVFSKFQYLRFSFLILFHKFEKNFRSTSFFNLFYYFRIYFYFIDL
>NZ_CP011410.1|WP_000405898.1|1517371_1519192_+|translational-GTPase-TypA
MEIRNIAIIAHVDHGKTTLLDGILRQTGAVTAKEDGERIMDSNDLEKEKGITIKAKNTAVVYKGTRINVVDTPGHADFGGEVERVLATADSCLLLVDAFDGPMPQTRFVLGKSLQLGHRPILVINKIDRPGARPEAVVDMAFDLFSDLGATDEQLDFPIVYASAKQGWAVHNLSESPGTNLDPLLDTVLKHVPPVQADTEAPLQFQVTSLDYNDYVGRIAVGKIYAGKMALGMNVIQLAAKKTETAPSADTALFRITKLYNFEGLKRNEVNAAEAGDIVAIAGLPDVFIGDTICEPGKPAPRPAIEVEEPTVSMFFMVNNSPFAGKEGKFVTTRNIRERLDRELETNVAMRLEETEDKDRFKVLGRGELHLSVLIETMRREGFEIQVSRPEVILKTNEQGQKLEPYEYLVMDVPDQFTGAIIAELNRRKGELQLMDAHPSGMTRVEFVIPTRGIIGFRGFFISETRGEGVMSSRFLRFDVYKGDIPGRKNGALISMDSGESTAYALWKIQERGELVIGPNTSVYPGMIIGIHSRDNDLEVNPVKEKKLSNVRSSGADEAIRLVPPRKFSLEQNIEFLDDDELLEVTPTSLRLRKKFLDANMRKRNK
>NZ_CP011410.1|WP_000691886.1|1512870_1513728_+|pirin-family-protein
MKIISAITKDLGENFQVRRILPSIKARYVGPFVFVDHMGPVSIQTGKELTVRSHPHIGLATITYLYDGVILHRDSIGSEMKICPYEVNWMTAGSGIAHSERSQLDLQYSILEGIQTWVALPKESEEVEPEFFHLNRNEIPVISEKGWELRLIAGEFLGKRSPVKVYSKLFYADLEVQSGGEGKWNISSDQESALYVARGSLEVQGQKIQMGNMAVFDLGETISFYSEEGSRSILLGGVPFPERRHLWWNFVSTSLERIEKAKLEWKQERFPEVPGETERIPLPEF
>NZ_CP011410.1|WP_000041092.1|1532854_1533847_-|aldolase
MSKLTHPREALFEGEKPFPIIPACEHFAGSEKLITKALELQNKLGGLFDITMDCEDGAQTGKEKEHAELIVRLQNSELNKHKMSGVRIHDYTNSFWKQDVDIIVPGAGEKIAYITIPKPTRAAQVEEMITYIQKAVQKAGIKREIPIHVLIETNGALQEVEKIAALPWLQVLDFGLMDFISGHHGAIPASCMKSPGQFEHELLRRGKANLVAAALANGVIPAHNVTLDLKNQYQTYKDAKRAHDDFGFLRMWSIYPTQIQAILDAMAPDYSEVQTAAEILIQAQNAEWGPIQYAGDLHDRATYRYFWEILQKAKLTGISIPEEANKRFFS
>NZ_CP011410.1|WP_000004530.1|1533986_1534922_-|ornithine-carbamoyltransferase
MSESNVKHLISWEDWSDSEILDLLDFAIHVKKNRVNYAGHMSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDWMASNFQLSDIDLEARYLSRNVSVIMARLKKHEDLLTMRNGSQVPLINGCDNMFHPCQSLADIMTIALDKPEIPLNQIQLTYIGVHNNVVNSLIGITSALGIRLTLVTPIAEKENIHSQTVERAKAKGTLSWEENLKKAIQNADYVYTDTWLDMEFFNDPSYADKKKQRMELMMPYQINSSLLEKTNAKVMHDMPIHAGYEITREVVLGPRSIIFQQAENRLDAQKAVILKLLEA
>NZ_CP011410.1|WP_000060053.1|1535725_1536193_+|hypothetical-protein
MSLTQEEMGDLVGPLSISIATRDAELKPHFARAFGVRISEDQKFMTVMVPKVIFEPCLKDINDNKLIAVTVAHMANFKTRQYKGLVQEIKDCTEADYELMKSVRESGAENSALFFGPKAGEGWNKYIIRPSVAVKFELSELFDQSPGIKAGEKLK
>NZ_CP011410.1|WP_001974506.1|1536189_1536594_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MIPEELQPCLQGIVPSIMVTCSKEGIPNATIVSQVYQVDSDHLAISNQFFGKTHKNVTENKYAIIQVLNPENLEPWLIDIYYKRTETEGELFDAMEMQLEAIASMSGMSDVFKLKAADIFEIRSVRKFTEAKES
>NZ_CP011410.1|WP_001974549.1|1536596_1537868_+|GAF-domain-containing-protein
MSDNQDVEDFKKQFVENQKGIEELNQKLHRKTREVEIIQSISAEILNTLDLEQIFERIMEVMDEVFGFKHAMILMLEEGTETLSVKASRGYEQGGVGAKVEFGQGVIGVVAKRKKIMRMVGITTQMRYAGQIGQSMGREEKQIELPGLKDAKSQIAIPLLVKDKLLGVFAVESAEMNAFKLLDEVILSVVGNQIAVAIENAAAYYTQQQLSEAYSRFVPKELLSLLSKKSILETQLADQTEGLMTVMFSDIRGFTTISEKMTPSENFQFINNYLGMIAPVIKEHNGFIDKFIGDAIMAIFPARAENAVEAALAMMKALQQFNELRQKENQDPIDIGIGIHTGHLMLGIIGHENRMEGTVIGDSVNLASRIEGLTKQFKCSIIVSEVTIASLRDPSRFTHSFLDEVTVKGKSQPIKVYKIENSV
>NZ_CP011410.1|WP_000826009.1|1538491_1540783_+|patatin-like-phospholipase-family-protein
MKRLLKDMDQFSSKAKHLKRLRYFYSKTSSEFPAWRNTKEEEIVAKHLNLIQWNSDILSLNVLPGSLCLVLSEKLEETLLNTKEKDLVLRELFPGDYFLFQPDKILHSGISEILYILPDELNRIISKLPNWKKWIEDLNQKNHLFHVSKLRPSKKELMSFLSSVELLFRLDKSTLSKLESRMEWLVIPGGEVLLKQGDSGDSMYILVSGRLSWTVRSEDEEILAEGELGKGDILGEMSLLSGDKRSATVIALRTSQVVRISREDFRKCFANSPEALFQITGTIAHRLGTERNQVYRKSKSVKTVSVFPLNFQENPDEFYRSLQNGLKNFGKTILVDYNSFKNREKSLKKRDTYRIGDLVNWFYDLEKYYDKLIFKTDIQNPGWRETCFRQSDRILVLIDPILPFSSYSEEINSMLPETIQKELVFLIDSDFMDWKKIESILKKFPSISHSIVRRRLDVDFGRLSRRLTGKSIGVALSGGGAKGFAHLGLLKCFEENEIPVDMISGTSAGAIMGGLFAMGLDSSDILPLIRNFWLDRNLLGDFTFPFVSLVRGKRYSQAIHEFFKDRSIETLPIPFYAIACNLTKAERKVFDRGLLWKAVRSSTSIPGIFPPFAERGELFVDGGLLDNLPGSILKERGAGILISVDLGGGGQIDKDEMYHNLLGPHYLGEAPSFFNLLFHHLKRKTLKTKYTGFAEIMMRSLMLSSKNNQNRTRNDSDLYIELPVGGYSTFDWDQFQKLYEIGYETGRKKIHIWKNEIKKKLIS
>NZ_CP011410.1|WP_001177543.1|1540850_1543523_+|PAS-domain-S-box-protein
MQLTGIKSLEEFSDSFSSFQDQICILEERPSGKIRLSKECIRFWQFKGFNRKPGTFPSFLFHLHGKIRNYADFTEKILLKHIQDSEYFDTLFTEDHILRFFWKVVFRKRGVSYRLYTFEILAKEGDDEEEGPDVESIFYKLPEPAFLFHPSTLRFLAVNDAALYLYGFSRKEFSEMNLLDIRPEEDRADMEIVIQNFAQDSGIRSRGIWRHWRKDKKFLYVKITTNRISFRGSFAVLVILTDVSETIETSYALKQSRAEKQSIIESMSDRYFALSKDWRFISANQQSLITLGKTQEELIGRNIWDLFSGSTSRFFKNRYEHAVQTKKPLVFDYKVPETGNIMEYRVFPFEEGISVFFQDITEKRRRETEQNILKEVTLKIPNASSVKQSFEILFETICKGTSWSFAQTWRFQKGEIILEENSPWYSSDASFLQYRMACLENKFSPGEGTIGKVFSTKKIRFVKDVQKEKDFKRTSAAVQNGIRSWIAIPLQTGHETYVLEFFTQIEIDLVNSYIQMFELIADQVGVLFKNKESEEEKDHFFKLSGDLFQISTLDGQVIEQNQAWEEILGYTPEELEEFDRTNIVHPEDRDKMLDAVRNVRKYKKNVSFALRYITKQGQTKTILWKTIASPEHGLVYASGKDITEIQDTQLKLENLTRELKRSNADLEDFAFIASHDLQEPLRKIMAFGDRLLKKNSNLDSESMDYLQRMYSSACRLSNLIEGLLSYSRIKSKSKPFQFLDLSSVLKDVIGDLEIYIKERNANVVDSKLGYAWCDPSQMGTVFQNLIKNGIKFNRSERPEVIVQCVAHPSEPNWIQISFSDNGIGFDKKHEDKIFTIFQRLHNREDYEGNGIGLAVCKKIIELHGGRIYAKSTLRKGSTFYLEFPGKLESD
>NZ_CP011410.1|WP_000642733.1|1543526_1543985_+|response-regulator
MKAEIKNQKTIHILVAEDDPDDRLLMKDGFRENNLANPLHFVKDGEELFEFLQNEGEYSDILKYPKPGIILLDLNMPRMDGREALKTIKSIPELKKIPVIVLTTSREEEDMFKTYDLGANSFIRKPVEFEAFLETIRALGKYWLEIVELPVV
>NZ_CP011410.1|WP_000490509.1|1543977_1545462_+|hybrid-sensor-histidine-kinase/response-regulator
MFSDEISVCLIEDDDEDAILFREYLEEIPFPKYKVTRFKDFPSLFVDIEKKPSKYTIYVVDHFLGLQTGFEILNEIRKVVGSVSAVLISGISKEEIERITSEGGFQGYLEKKNLSAFTLAKTFFEVLKEKEDLRSETDIFLLKMEIISQFSGGVAHDFNNILNIIVANLDILEMKCKDQPEVLNRIQSAQNAVLRGAEVNKKLLNFSRKQSLHPEIINPNLFIADFLEKSKNIFSENVQLVFNPGSQEVFCKVDQTEFANCIMNLLQNANEASGGKILIETDTIVLNSKNKSLGLKEGNYFLLRVADNGKGIDLSIADRIFEPFFTTKQKGKNPGLGLPMVFGFVKRSGGRIGFESHLDVGSDFYIYIPIEDLKSDSHFINLESSKKTIFYFSNEGEFSSRTSYLFQGLGYRVLCFKDLNVLESNLSKIQSETILVSQTWQEDFFRWKEIVMKAQGSGLKVKFFYFSSSVDLENSTSIPWPISRKSLENHFGIL
>NZ_CP011410.1|WP_047020767.1|1545473_1546688_+|EAL-domain-containing-response-regulator
MNQTTLPNLLILDDEEEIAGILGDLARQCGFEVTITHEAGVFSERLNEKTQYIILDLMIPDVDGVDVLRMLSGKKFSISVILISGADRRVLQSAEALAIQYGLKISGVLEKPIRIREYQKLLTGLISEQKNESAHSFTSGKRIVHEQASVIGPEEIEQGIRENQFVLFYQPKIDFKTGTVSGFESLVRWSHPERGLIFPDAFIPTLELYPSLMDAMTEKLILQALSQCSIWNKQFPGIAVAVNVSPVSMNKLILPETIAKMIENFGLKNNQLIVEVTETQLLENMTSTLDILTRIRIRGIGLSVDDFGIGYSSLKQIHRYPFTELKIDRSFVSVAPYDKEALFICQAAIDLGHKLGMTVVAEGIETAEVGELMKQQGCDKGQGYFYSKPMPANSTLQFLAGFKS

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Crispr_ID: NZ_CP011410_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011410_6

1530631-1530935

Orphan

Consensus_repeat	Method
TTCCTAAAGAAATAGGGAATTTAAAAAA	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP011410_6

>merge|NZ_CP011410|6|1530631-1530935|CRISPRCasFinder
TTCCAAAGGAAATTGGAAACTTACAAAATTTAAAAGAATTATATTTAAGCGCGAACGAAATTACAACTCTGCCTCCTGAAATAGGAAATTTAAAAAACTTACAGGTATTGTCTTTAAATGGAAACAGACTTGAAACGATTCCTAAAGAAATAGGGAATTTAAAAAAACTAAAAGAACTGTCAATAGAATGGAATAAACTTCAAACACTTCCTAAAGAAATAGGAAATTTAAAAAATTTAAAAGAATTATATTTAAGCAGAAATCAACTCAAAATATTACCGCAAGAAATCGGGAACTTAAGAAAA

>NZ_CP011410|6|6|1530631-1530935|CRISPRCasFinder
TTCCAAAGGAAATTGGAAACTTACAAAA	TTTAAAAGAATTATATTTAAGCGCGAACGAAATTACAACTC
TGCCTCCTGAAATAGGAAATTTAAAAAA	CTTACAGGTATTGTCTTTAAATGGAAACAGACTTGAAACGA
TTCCTAAAGAAATAGGGAATTTAAAAAA	ACTAAAAGAACTGTCAATAGAATGGAATAAACTTCAAACAC
TTCCTAAAGAAATAGGAAATTTAAAAAA	TTTAAAAGAATTATATTTAAGCAGAAATCAACTCAAAATAT
TACCGCAAGAAATCGGGAACTTAAGAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011410.1\|WP_047020767.1\|1545473_1546688_+\|EAL-domain-containing-response-regulator	unknown	unknown	gnl\|CDD\|238923
NZ_CP011410.1\|WP_000041092.1\|1532854_1533847_-\|aldolase	unknown	unknown	gnl\|CDD\|225184
NZ_CP011410.1\|WP_000875151.1\|1527430_1528333_-\|SH3-domain-containing-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000004530.1\|1533986_1534922_-\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|173265
NZ_CP011410.1\|WP_000405898.1\|1517371_1519192_+\|translational-GTPase-TypA	unknown	unknown	gnl\|CDD\|224138
NZ_CP011410.1\|WP_000060053.1\|1535725_1536193_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000869776.1\|1522053_1523235_+\|DJ-1/PfpI-family-protein	unknown	unknown	gnl\|CDD\|153233
NZ_CP011410.1\|WP_000788714.1\|1525462_1526530_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NZ_CP011410.1\|WP_000826009.1\|1538491_1540783_+\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132844
NZ_CP011410.1\|WP_000808860.1\|1519915_1520098_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000691886.1\|1512870_1513728_+\|pirin-family-protein	unknown	unknown	gnl\|CDD\|224655
NZ_CP011410.1\|WP_000490509.1\|1543977_1545462_+\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|237425
NZ_CP011410.1\|WP_000642921.1\|1520488_1521700_+\|acyltransferase	unknown	unknown	gnl\|CDD\|224748
NZ_CP011410.1\|WP_001158185.1\|1524311_1525406_-\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223260
NZ_CP011410.1\|WP_001177543.1\|1540850_1543523_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|226702
NZ_CP011410.1\|WP_000642733.1\|1543526_1543985_+\|response-regulator	unknown	unknown	gnl\|CDD\|381108
NZ_CP011410.1\|WP_002097271.1\|1529958_1530441_+\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP011410.1\|WP_000068280.1\|1526734_1527199_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|317965
NZ_CP011410.1\|WP_001974549.1\|1536596_1537868_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NZ_CP011410.1\|WP_001974506.1\|1536189_1536594_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|334450

Protein	Function_ID	Function_description	E-value
NZ_CP011410.1\|WP_047020767.1\|1545473_1546688_+\|EAL-domain-containing-response-regulator	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.14379e-89
NZ_CP011410.1\|WP_000041092.1\|1532854_1533847_-\|aldolase	gnl\|CDD\|225184	COG2301, CitE, Citrate lyase beta subunit [Carbohydrate transport and metabolism].	2.80269e-30
NZ_CP011410.1\|WP_000004530.1\|1533986_1534922_-\|ornithine-carbamoyltransferase	gnl\|CDD\|173265	PRK14804, PRK14804, ornithine carbamoyltransferase; Provisional.	0
NZ_CP011410.1\|WP_000405898.1\|1517371_1519192_+\|translational-GTPase-TypA	gnl\|CDD\|224138	COG1217, TypA, Predicted membrane GTPase involved in stress response [Signal transduction mechanisms].	0
NZ_CP011410.1\|WP_000826009.1\|1538491_1540783_+\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132844	cd07205, Pat_PNPLA6_PNPLA7_NTE1_like, Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1. Patatin-like phospholipase domain containing protein 6 (PNPLA6) and protein 7 (PNPLA7) are included in this family. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. PNPLA7 is an insulin-regulated phospholipase that is homologus to Neuropathy Target Esterase (NTE or PNPLA6) and is also known as NTE-related esterase (NRE). Human NRE is predominantly expressed in prostate, white adipose, and pancreatic tissue. NRE hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid, but shows no lipase activity with substrates like triacylglycerols (TG), cholesteryl esters, retinyl esters (RE), phosphatidylcholine (PC), or monoacylglycerol (MG). This family includes subfamily of PNPLA6 (NTE) and PNPLA7 (NRE)-like phospholipases.	1.10439e-84
NZ_CP011410.1\|WP_000869776.1\|1522053_1523235_+\|DJ-1/PfpI-family-protein	gnl\|CDD\|153233	cd03139, GATase1_PfpI_2, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	2.76455e-29
NZ_CP011410.1\|WP_000788714.1\|1525462_1526530_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	2.21184e-17
NZ_CP011410.1\|WP_000691886.1\|1512870_1513728_+\|pirin-family-protein	gnl\|CDD\|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	3.37928e-71
NZ_CP011410.1\|WP_000490509.1\|1543977_1545462_+\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|237425	PRK13557, PRK13557, histidine kinase; Provisional.	1.2441e-48
NZ_CP011410.1\|WP_000642921.1\|1520488_1521700_+\|acyltransferase	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	1.15187e-34
NZ_CP011410.1\|WP_001158185.1\|1524311_1525406_-\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|223260	COG0182, COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis].	6.51899e-149
NZ_CP011410.1\|WP_001177543.1\|1540850_1543523_+\|PAS-domain-S-box-protein	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	2.00639e-57
NZ_CP011410.1\|WP_000642733.1\|1543526_1543985_+\|response-regulator	gnl\|CDD\|381108	cd17557, REC_Rcp-like, phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains. This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	4.74194e-67
NZ_CP011410.1\|WP_002097271.1\|1529958_1530441_+\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	2.58313e-15
NZ_CP011410.1\|WP_000068280.1\|1526734_1527199_+\|hypothetical-protein	gnl\|CDD\|317965	pfam15662, SPATA3, Spermatogenesis-associated protein 3 family. The SPATA3 family of proteins is expressed significantly in testis and faintly in epididymis in the ten tissues of testis, ovary, spleen, kidney, lung, heart, brain, epididymis, liver and skeletal muscle in mouse. Members are not expressed in the eight other tissues. This suggests that SPATA3 plays potential roles in spermatogenesis cell apoptosis or spermatogenesis.	0.00530056
NZ_CP011410.1\|WP_001974549.1\|1536596_1537868_+\|GAF-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	3.05827e-63
NZ_CP011410.1\|WP_001974506.1\|1536189_1536594_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|334450	pfam01243, Putative_PNPOx, Pyridoxamine 5'-phosphate oxidase. Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as yeast YLR456W and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.	4.13554e-11

>NZ_CP011410.1|WP_002097271.1|1529958_1530441_+|rhodanese-like-domain-containing-protein
MAKESDFVKTKRNPIPNRLIDYKKFQNIVNSSAEEREAKRLTEEEFLNMIQDKEVVLLDARSESRYKLRHIKGAVSLPFTEFTKESLAKVIPKINSKILMYCNNNFMGSPEAFASKAPAASLNLSTFISLKAYGYKNIYELGPLLSVDSTKFTFEGTEVQ
>NZ_CP011410.1|WP_000875151.1|1527430_1528333_-|SH3-domain-containing-protein
MKYILSSIGFVLFLIGNNLISAEIESCFTSYPEVVVRDSPNTSGKKVRIIKQSIPLKILERTSTLEEIKIRNRKVQSNWVKISDGWIFGGLIQCIPKIFFAHPISYHEEELPFSPSDSTNWIAIFLQQESYLRKQISIDLKREHDTVVDQNENIKTGYKVNVINNPIVLIKGITFKKGNFPAITKKVPLELEFGKSYHFNFEKDNYRITSKGKPTQSSGINGYQLILHKNNEEMIIDSRVYRTEKPILVFAGDIDGDGELDFIFDLKDHYNVSNEHLYISSEKINDFFIVPVAANWNTGC
>NZ_CP011410.1|WP_000068280.1|1526734_1527199_+|hypothetical-protein
MAQNKKSALFDILKREKLEKMLKRNSSSGQSQSNEKPQTSVSENVPEKSSTEKKEPQTSKIYKAIEDVKLDIRYYFLQDEYVEKLASIYIKNEGPLEKLGIDPKKYLEYARDSFDRYKQLDKKMPLEPMNKKSWDHVEKSLNELITKLLEKFSK
>NZ_CP011410.1|WP_000788714.1|1525462_1526530_+|rhomboid-family-intramembrane-serine-protease
MKNHSPSPGECGNPGQICPGLALLDSLTTIRILSNMAKRKYRNGISLFGYSIFHPINLILIVNVLVYILQLFAGGTGIIEYYFALTPFRVFHGHYWQVFSYGFLHEAYGIPFIHLFFNMYVFVMFGGLICRYVSAWKFTVVYLTAILTGGITVLLAPVLNEILGIHYPMDLFQTTTLGASGGVTGILVLFGILFPETEVFLVFFRMKARYAAWIFVGGGFVADFVAVYYFHSPFVVSNSCHLGGAIGATLVAPLILKNNFGKIFPKNKDSENTKPTRSLNEDLDFQTQKNLKLLDELSKKISYSDQEDILIPLQQTNVNLCPPPTFQPEDPFCLRCDWLPNCALRKLKTSSEKTP
>NZ_CP011410.1|WP_001158185.1|1524311_1525406_-|S-methyl-5-thioribose-1-phosphate-isomerase
MQESGLKPILWKNKELILLDQRVLPGTTSYITAKTLEDCIFAIREMVVRGAPAIAITGAFGITLYWNSLVSKPSFSELKLKLSELLESRPTAVNLRLAIEEFSSRFPESNYSSFSLEEIQKGAEELALFMLSEDLENNLTLSKYALSLFPKQPSSLNIITHCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELQEEKIQSFLITDNMAGWVMSSRKIDAVIVGADRIASNGDTANKIGTYPLAIVAKHHGVPFYVAATAKSMDFRIPNGSYIPIEMRKEEEITSFGFLKDSDGKPLLKEGVIAPKGMKALNPSFDVTPASLITGIITEKGIVSPVTEENLKKIFQSI
>NZ_CP011410.1|WP_000869776.1|1522053_1523235_+|DJ-1/PfpI-family-protein
MKVVQIKLSFISRKFQKYSKIIMLILICFMCVLYDSLSGETKKPAYSTEDLSKSQYKSEKIPVYQNRFGRTRPVIAVIGDNYMTELTDYVVPYGVLTRSKSAEVFAVGISLTPISFYPALKIFPQESISSFDKKFSTGADYVIVPAIHHSENPILLEWLNLQASRGATIIGVCDGVWVLANAGLLKGKRATGFWYSLDDLEKKFKDTTWVRNRRYVVDQGIVTTTAVTASIPVSLALVEAIAGKDRAFNVAVELGVQDWSPVHDSNRFRLTMSSVYTVVSNFLSFWSYEKIGIPVMAGVDEIKLALVADAYSRTYRSQAFSIAKSEETIRTSNGLRLIPDIVFGSTTSLSRILPVFDSTPAVITLDQTLLKIGEIYGRSTADFVALILEYPYF
>NZ_CP011410.1|WP_000642921.1|1520488_1521700_+|acyltransferase
MKAFIKGLWYHREDEIQSLNGLRAFAIILVILNHYALVWKKPGTFQSDSLFWSGVDLSFVLSGFLISKSLLSDWTRNATIDFKKFYLKRTLRIFPAYYVFITFSWVASKLTLKIAEAKGLEKEAYYFSFKLSDAWGDFVFLGNYFPGINIHTWSLSIEEQFYLIFPLFCSLILFKMSSKYRQLLLWSLLLVPTISRVIVYMTTPLPLTPEYFNEIYFPFHTRFDSLVIGVIVMDLYMNQKGLINRLKTNPILYYLLLFLFFSFLCISHWANINMESFFTHTFKYNLLNIGFAGILLCAVVRSEGLLGRFLSLKIFVPIARLSFTIYLWHLVLIAVSVSILKIRTEPSSMFELLFQFIFVLTLMILLSVPFYLLFEYPFQYLRTRILPKRRSHKQLLSVQPKSF
>NZ_CP011410.1|WP_000808860.1|1519915_1520098_+|hypothetical-protein
MKQFRFFVIAFFLKKFVFSKFQYLRFSFLILFHKFEKNFRSTSFFNLFYYFRIYFYFIDL
>NZ_CP011410.1|WP_000405898.1|1517371_1519192_+|translational-GTPase-TypA
MEIRNIAIIAHVDHGKTTLLDGILRQTGAVTAKEDGERIMDSNDLEKEKGITIKAKNTAVVYKGTRINVVDTPGHADFGGEVERVLATADSCLLLVDAFDGPMPQTRFVLGKSLQLGHRPILVINKIDRPGARPEAVVDMAFDLFSDLGATDEQLDFPIVYASAKQGWAVHNLSESPGTNLDPLLDTVLKHVPPVQADTEAPLQFQVTSLDYNDYVGRIAVGKIYAGKMALGMNVIQLAAKKTETAPSADTALFRITKLYNFEGLKRNEVNAAEAGDIVAIAGLPDVFIGDTICEPGKPAPRPAIEVEEPTVSMFFMVNNSPFAGKEGKFVTTRNIRERLDRELETNVAMRLEETEDKDRFKVLGRGELHLSVLIETMRREGFEIQVSRPEVILKTNEQGQKLEPYEYLVMDVPDQFTGAIIAELNRRKGELQLMDAHPSGMTRVEFVIPTRGIIGFRGFFISETRGEGVMSSRFLRFDVYKGDIPGRKNGALISMDSGESTAYALWKIQERGELVIGPNTSVYPGMIIGIHSRDNDLEVNPVKEKKLSNVRSSGADEAIRLVPPRKFSLEQNIEFLDDDELLEVTPTSLRLRKKFLDANMRKRNK
>NZ_CP011410.1|WP_000691886.1|1512870_1513728_+|pirin-family-protein
MKIISAITKDLGENFQVRRILPSIKARYVGPFVFVDHMGPVSIQTGKELTVRSHPHIGLATITYLYDGVILHRDSIGSEMKICPYEVNWMTAGSGIAHSERSQLDLQYSILEGIQTWVALPKESEEVEPEFFHLNRNEIPVISEKGWELRLIAGEFLGKRSPVKVYSKLFYADLEVQSGGEGKWNISSDQESALYVARGSLEVQGQKIQMGNMAVFDLGETISFYSEEGSRSILLGGVPFPERRHLWWNFVSTSLERIEKAKLEWKQERFPEVPGETERIPLPEF
>NZ_CP011410.1|WP_000041092.1|1532854_1533847_-|aldolase
MSKLTHPREALFEGEKPFPIIPACEHFAGSEKLITKALELQNKLGGLFDITMDCEDGAQTGKEKEHAELIVRLQNSELNKHKMSGVRIHDYTNSFWKQDVDIIVPGAGEKIAYITIPKPTRAAQVEEMITYIQKAVQKAGIKREIPIHVLIETNGALQEVEKIAALPWLQVLDFGLMDFISGHHGAIPASCMKSPGQFEHELLRRGKANLVAAALANGVIPAHNVTLDLKNQYQTYKDAKRAHDDFGFLRMWSIYPTQIQAILDAMAPDYSEVQTAAEILIQAQNAEWGPIQYAGDLHDRATYRYFWEILQKAKLTGISIPEEANKRFFS
>NZ_CP011410.1|WP_000004530.1|1533986_1534922_-|ornithine-carbamoyltransferase
MSESNVKHLISWEDWSDSEILDLLDFAIHVKKNRVNYAGHMSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDWMASNFQLSDIDLEARYLSRNVSVIMARLKKHEDLLTMRNGSQVPLINGCDNMFHPCQSLADIMTIALDKPEIPLNQIQLTYIGVHNNVVNSLIGITSALGIRLTLVTPIAEKENIHSQTVERAKAKGTLSWEENLKKAIQNADYVYTDTWLDMEFFNDPSYADKKKQRMELMMPYQINSSLLEKTNAKVMHDMPIHAGYEITREVVLGPRSIIFQQAENRLDAQKAVILKLLEA
>NZ_CP011410.1|WP_000060053.1|1535725_1536193_+|hypothetical-protein
MSLTQEEMGDLVGPLSISIATRDAELKPHFARAFGVRISEDQKFMTVMVPKVIFEPCLKDINDNKLIAVTVAHMANFKTRQYKGLVQEIKDCTEADYELMKSVRESGAENSALFFGPKAGEGWNKYIIRPSVAVKFELSELFDQSPGIKAGEKLK
>NZ_CP011410.1|WP_001974506.1|1536189_1536594_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MIPEELQPCLQGIVPSIMVTCSKEGIPNATIVSQVYQVDSDHLAISNQFFGKTHKNVTENKYAIIQVLNPENLEPWLIDIYYKRTETEGELFDAMEMQLEAIASMSGMSDVFKLKAADIFEIRSVRKFTEAKES
>NZ_CP011410.1|WP_001974549.1|1536596_1537868_+|GAF-domain-containing-protein
MSDNQDVEDFKKQFVENQKGIEELNQKLHRKTREVEIIQSISAEILNTLDLEQIFERIMEVMDEVFGFKHAMILMLEEGTETLSVKASRGYEQGGVGAKVEFGQGVIGVVAKRKKIMRMVGITTQMRYAGQIGQSMGREEKQIELPGLKDAKSQIAIPLLVKDKLLGVFAVESAEMNAFKLLDEVILSVVGNQIAVAIENAAAYYTQQQLSEAYSRFVPKELLSLLSKKSILETQLADQTEGLMTVMFSDIRGFTTISEKMTPSENFQFINNYLGMIAPVIKEHNGFIDKFIGDAIMAIFPARAENAVEAALAMMKALQQFNELRQKENQDPIDIGIGIHTGHLMLGIIGHENRMEGTVIGDSVNLASRIEGLTKQFKCSIIVSEVTIASLRDPSRFTHSFLDEVTVKGKSQPIKVYKIENSV
>NZ_CP011410.1|WP_000826009.1|1538491_1540783_+|patatin-like-phospholipase-family-protein
MKRLLKDMDQFSSKAKHLKRLRYFYSKTSSEFPAWRNTKEEEIVAKHLNLIQWNSDILSLNVLPGSLCLVLSEKLEETLLNTKEKDLVLRELFPGDYFLFQPDKILHSGISEILYILPDELNRIISKLPNWKKWIEDLNQKNHLFHVSKLRPSKKELMSFLSSVELLFRLDKSTLSKLESRMEWLVIPGGEVLLKQGDSGDSMYILVSGRLSWTVRSEDEEILAEGELGKGDILGEMSLLSGDKRSATVIALRTSQVVRISREDFRKCFANSPEALFQITGTIAHRLGTERNQVYRKSKSVKTVSVFPLNFQENPDEFYRSLQNGLKNFGKTILVDYNSFKNREKSLKKRDTYRIGDLVNWFYDLEKYYDKLIFKTDIQNPGWRETCFRQSDRILVLIDPILPFSSYSEEINSMLPETIQKELVFLIDSDFMDWKKIESILKKFPSISHSIVRRRLDVDFGRLSRRLTGKSIGVALSGGGAKGFAHLGLLKCFEENEIPVDMISGTSAGAIMGGLFAMGLDSSDILPLIRNFWLDRNLLGDFTFPFVSLVRGKRYSQAIHEFFKDRSIETLPIPFYAIACNLTKAERKVFDRGLLWKAVRSSTSIPGIFPPFAERGELFVDGGLLDNLPGSILKERGAGILISVDLGGGGQIDKDEMYHNLLGPHYLGEAPSFFNLLFHHLKRKTLKTKYTGFAEIMMRSLMLSSKNNQNRTRNDSDLYIELPVGGYSTFDWDQFQKLYEIGYETGRKKIHIWKNEIKKKLIS
>NZ_CP011410.1|WP_001177543.1|1540850_1543523_+|PAS-domain-S-box-protein
MQLTGIKSLEEFSDSFSSFQDQICILEERPSGKIRLSKECIRFWQFKGFNRKPGTFPSFLFHLHGKIRNYADFTEKILLKHIQDSEYFDTLFTEDHILRFFWKVVFRKRGVSYRLYTFEILAKEGDDEEEGPDVESIFYKLPEPAFLFHPSTLRFLAVNDAALYLYGFSRKEFSEMNLLDIRPEEDRADMEIVIQNFAQDSGIRSRGIWRHWRKDKKFLYVKITTNRISFRGSFAVLVILTDVSETIETSYALKQSRAEKQSIIESMSDRYFALSKDWRFISANQQSLITLGKTQEELIGRNIWDLFSGSTSRFFKNRYEHAVQTKKPLVFDYKVPETGNIMEYRVFPFEEGISVFFQDITEKRRRETEQNILKEVTLKIPNASSVKQSFEILFETICKGTSWSFAQTWRFQKGEIILEENSPWYSSDASFLQYRMACLENKFSPGEGTIGKVFSTKKIRFVKDVQKEKDFKRTSAAVQNGIRSWIAIPLQTGHETYVLEFFTQIEIDLVNSYIQMFELIADQVGVLFKNKESEEEKDHFFKLSGDLFQISTLDGQVIEQNQAWEEILGYTPEELEEFDRTNIVHPEDRDKMLDAVRNVRKYKKNVSFALRYITKQGQTKTILWKTIASPEHGLVYASGKDITEIQDTQLKLENLTRELKRSNADLEDFAFIASHDLQEPLRKIMAFGDRLLKKNSNLDSESMDYLQRMYSSACRLSNLIEGLLSYSRIKSKSKPFQFLDLSSVLKDVIGDLEIYIKERNANVVDSKLGYAWCDPSQMGTVFQNLIKNGIKFNRSERPEVIVQCVAHPSEPNWIQISFSDNGIGFDKKHEDKIFTIFQRLHNREDYEGNGIGLAVCKKIIELHGGRIYAKSTLRKGSTFYLEFPGKLESD
>NZ_CP011410.1|WP_000642733.1|1543526_1543985_+|response-regulator
MKAEIKNQKTIHILVAEDDPDDRLLMKDGFRENNLANPLHFVKDGEELFEFLQNEGEYSDILKYPKPGIILLDLNMPRMDGREALKTIKSIPELKKIPVIVLTTSREEEDMFKTYDLGANSFIRKPVEFEAFLETIRALGKYWLEIVELPVV
>NZ_CP011410.1|WP_000490509.1|1543977_1545462_+|hybrid-sensor-histidine-kinase/response-regulator
MFSDEISVCLIEDDDEDAILFREYLEEIPFPKYKVTRFKDFPSLFVDIEKKPSKYTIYVVDHFLGLQTGFEILNEIRKVVGSVSAVLISGISKEEIERITSEGGFQGYLEKKNLSAFTLAKTFFEVLKEKEDLRSETDIFLLKMEIISQFSGGVAHDFNNILNIIVANLDILEMKCKDQPEVLNRIQSAQNAVLRGAEVNKKLLNFSRKQSLHPEIINPNLFIADFLEKSKNIFSENVQLVFNPGSQEVFCKVDQTEFANCIMNLLQNANEASGGKILIETDTIVLNSKNKSLGLKEGNYFLLRVADNGKGIDLSIADRIFEPFFTTKQKGKNPGLGLPMVFGFVKRSGGRIGFESHLDVGSDFYIYIPIEDLKSDSHFINLESSKKTIFYFSNEGEFSSRTSYLFQGLGYRVLCFKDLNVLESNLSKIQSETILVSQTWQEDFFRWKEIVMKAQGSGLKVKFFYFSSSVDLENSTSIPWPISRKSLENHFGIL
>NZ_CP011410.1|WP_047020767.1|1545473_1546688_+|EAL-domain-containing-response-regulator
MNQTTLPNLLILDDEEEIAGILGDLARQCGFEVTITHEAGVFSERLNEKTQYIILDLMIPDVDGVDVLRMLSGKKFSISVILISGADRRVLQSAEALAIQYGLKISGVLEKPIRIREYQKLLTGLISEQKNESAHSFTSGKRIVHEQASVIGPEEIEQGIRENQFVLFYQPKIDFKTGTVSGFESLVRWSHPERGLIFPDAFIPTLELYPSLMDAMTEKLILQALSQCSIWNKQFPGIAVAVNVSPVSMNKLILPETIAKMIENFGLKNNQLIVEVTETQLLENMTSTLDILTRIRIRGIGLSVDDFGIGYSSLKQIHRYPFTELKIDRSFVSVAPYDKEALFICQAAIDLGHKLGMTVVAEGIETAEVGELMKQQGCDKGQGYFYSKPMPANSTLQFLAGFKS

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Crispr_ID: NZ_CP011410_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011410_8

1677141-1677234

Orphan

Consensus_repeat	Method
AGGAAAGCGTTGTGTTGAGTTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011410_8

>merge|NZ_CP011410|8|1677141-1677234|CRISPRCasFinder
AGGAAAGCGTTGTGTTGAGTTTTCCAACGCGACCTGCAGAGCGACCCTTAGGGAGCGATGCATTGAGTTTGAGGAAAGCGTTGTGTTGAGTTTT

>NZ_CP011410|8|8|1677141-1677234|CRISPRCasFinder
AGGAAAGCGTTGTGTTGAGTTTT	CCAACGCGACCTGCAGAGCGACCCTTAGGGAGCGATGCATTGAGTTTG
AGGAAAGCGTTGTGTTGAGTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011410.1\|WP_000146503.1\|1667350_1668454_+\|dehypoxanthine-futalosine-cyclase	unknown	unknown	gnl\|CDD\|274731
NZ_CP011410.1\|WP_000181054.1\|1678528_1679779_-\|N-6-DNA-methylase	unknown	unknown	gnl\|CDD\|236981
NZ_CP011410.1\|WP_000287366.1\|1680389_1681508_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238425
NZ_CP011410.1\|WP_002097198.1\|1681521_1682553_+\|glycosyltransferase-family-9-protein	unknown	unknown	gnl\|CDD\|340821
NZ_CP011410.1\|WP_000583497.1\|1685479_1686016_+\|DUF1564-family-protein	unknown	unknown	gnl\|CDD\|284922
NZ_CP011410.1\|WP_000683304.1\|1689330_1690512_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|349941
NZ_CP011410.1\|WP_000173137.1\|1669276_1669681_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_001016365.1\|1677400_1678513_-\|acetylglutamate-kinase	unknown	unknown	gnl\|CDD\|235306
NZ_CP011410.1\|WP_002068674.1\|1666923_1667085_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000591544.1\|1684190_1684754_+\|DUF1564-family-protein	unknown	unknown	gnl\|CDD\|284922
NZ_CP011410.1\|WP_001194243.1\|1675661_1676006_-\|DUF393-domain-containing-protein	unknown	unknown	gnl\|CDD\|367833
NZ_CP011410.1\|WP_001239790.1\|1669664_1670894_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP011410.1\|WP_000677991.1\|1679775_1680243_-\|bacterioferritin	unknown	unknown	gnl\|CDD\|153099
NZ_CP011410.1\|WP_001113397.1\|1671007_1671817_-\|GerMN-domain-containing-protein	unknown	unknown	gnl\|CDD\|214905
NZ_CP011410.1\|WP_001038601.1\|1673861_1674986_+\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|273498
NZ_CP011410.1\|WP_000205137.1\|1682549_1683839_+\|aminopeptidase-P-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|182804
NZ_CP011410.1\|WP_001190720.1\|1674998_1675685_+\|iron-containing-redox-enzyme-family-protein	unknown	unknown	gnl\|CDD\|379634
NZ_CP011410.1\|WP_000215704.1\|1671860_1672535_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NZ_CP011410.1\|WP_001097878.1\|1672618_1673869_+\|KamA-family-radical-SAM-protein	unknown	unknown	gnl\|CDD\|224426
NZ_CP011410.1\|WP_134795163.1\|1688512_1688671_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011410.1\|WP_000146503.1\|1667350_1668454_+\|dehypoxanthine-futalosine-cyclase	gnl\|CDD\|274731	TIGR03699, menaquin_MqnC, dehypoxanthine futalosine cyclase. members of this protein family are involved in menaquinone biosynthesis by an alternate pathway via futalosine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	0
NZ_CP011410.1\|WP_000181054.1\|1678528_1679779_-\|N-6-DNA-methylase	gnl\|CDD\|236981	PRK11783, rlmL, bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL.	3.4615e-84
NZ_CP011410.1\|WP_000287366.1\|1680389_1681508_+\|thiolase-family-protein	gnl\|CDD\|238425	cd00829, SCP-x_thiolase, Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.	3.33851e-92
NZ_CP011410.1\|WP_002097198.1\|1681521_1682553_+\|glycosyltransferase-family-9-protein	gnl\|CDD\|340821	cd03789, GT9_LPS_heptosyltransferase, lipopolysaccharide heptosyltransferase and similar proteins. Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	3.2648e-66
NZ_CP011410.1\|WP_000683304.1\|1689330_1690512_-\|amidohydrolase	gnl\|CDD\|349941	cd08021, M20_Acy1_YhaA-like, M20 Peptidase aminoacylase 1 subfamily, includes Bacillus subtilis YhaA and Staphylococcus aureus amidohydrolase, SACOL0085. Peptidase M20 family, uncharacterized subfamily of bacterial proteins predicted as putative amidohydrolases or hippurate hydrolases. These are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine). This family includes Staphylococcus aureus amidohydrolase, SACOL0085, which contains two manganese ions in the active site, and forms a homotetramer with variations in interdomain orientation which possibly plays a role in the regulation of catalytic activity.	0
NZ_CP011410.1\|WP_001097878.1\|1672618_1673869_+\|KamA-family-radical-SAM-protein	gnl\|CDD\|224426	COG1509, KamA, Lysine 2,3-aminomutase [Amino acid transport and metabolism].	2.14014e-125
NZ_CP011410.1\|WP_001016365.1\|1677400_1678513_-\|acetylglutamate-kinase	gnl\|CDD\|235306	PRK04531, PRK04531, acetylglutamate kinase; Provisional.	0
NZ_CP011410.1\|WP_000583497.1\|1685479_1686016_+\|DUF1564-family-protein	gnl\|CDD\|284922	pfam07600, DUF1564, Protein of unknown function (DUF1564). A family of paralogous proteins in Leptospira interrogans. Several have been annotated as possible CopG-like transcriptional regulators (see pfam01402).	5.3303e-08
NZ_CP011410.1\|WP_000591544.1\|1684190_1684754_+\|DUF1564-family-protein	gnl\|CDD\|284922	pfam07600, DUF1564, Protein of unknown function (DUF1564). A family of paralogous proteins in Leptospira interrogans. Several have been annotated as possible CopG-like transcriptional regulators (see pfam01402).	6.21791e-12
NZ_CP011410.1\|WP_001194243.1\|1675661_1676006_-\|DUF393-domain-containing-protein	gnl\|CDD\|367833	pfam04134, DUF393, Protein of unknown function, DUF393. Members of this family have two highly conserved cysteine residues near their N-terminus. The function of these proteins is unknown.	1.1554e-11
NZ_CP011410.1\|WP_001239790.1\|1669664_1670894_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.43468e-56
NZ_CP011410.1\|WP_000677991.1\|1679775_1680243_-\|bacterioferritin	gnl\|CDD\|153099	cd00907, Bacterioferritin, Bacterioferritin, ferritin-like diiron-binding domain. Bacterioferritins, also known as cytochrome b1, are members of a broad superfamily of ferritin-like diiron-carboxylate proteins. Similar to ferritin in architecture, Bfr forms an oligomer of 24 subunits that assembles to form a hollow sphere with 432 symmetry. Up to 12 heme cofactor groups (iron protoporphyrin IX or coproporphyrin III) are bound between dimer pairs. The role of the heme is unknown, although it may be involved in mediating iron-core reduction and iron release. Each subunit is composed of a four-helix bundle which carries a diiron ferroxidase center; it is here that initial oxidation of ferrous iron by molecular oxygen occurs, facilitating the detoxification of iron, protection against dioxygen and radical products, and storage of ferric-hydroxyphosphate at the core. Some bacterioferritins are composed of two subunit types, one conferring heme-binding ability (alpha) and the other (beta) bestowing ferroxidase activity.	3.15748e-76
NZ_CP011410.1\|WP_001113397.1\|1671007_1671817_-\|GerMN-domain-containing-protein	gnl\|CDD\|214905	smart00909, Germane, Sporulation and spore germination. The GerMN domain is a region of approximately 100 residues that is found, duplicated, in the Bacillus GerM protein and is implicated in both sporulation and spore germination. The domain is found in a number of different bacterial species both alone and in association with other domains such as Amidase_3 pfam01520 Gmad1 and Gmad2. It is predicted to have a novel alpha-beta fold.	1.14648e-11
NZ_CP011410.1\|WP_001038601.1\|1673861_1674986_+\|D-alanine--D-alanine-ligase	gnl\|CDD\|273498	TIGR01205, D-alanine--D-alanine_ligase, D-alanine--D-alanine ligase. This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	1.97983e-23
NZ_CP011410.1\|WP_000205137.1\|1682549_1683839_+\|aminopeptidase-P-N-terminal-domain-containing-protein	gnl\|CDD\|182804	PRK10879, PRK10879, proline aminopeptidase P II; Provisional.	1.39938e-122
NZ_CP011410.1\|WP_001190720.1\|1674998_1675685_+\|iron-containing-redox-enzyme-family-protein	gnl\|CDD\|379634	pfam14518, Haem_oxygenas_2, Iron-containing redox enzyme. The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase.	4.37451e-24
NZ_CP011410.1\|WP_000215704.1\|1671860_1672535_-\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	5.83297e-25

>NZ_CP011410.1|WP_001194243.1|1675661_1676006_-|DUF393-domain-containing-protein
MQTLVFLYDGECSFCRNLAKKLQSLNLNPKIRFRSFRDFTEKELKEIHPTLNIRVAEGNVQMIANGRRYPGFFAVRKLSHSLKGYRWVSPLLYLPLIPIFGMIGMIFLKSLKSR
>NZ_CP011410.1|WP_001190720.1|1674998_1675685_+|iron-containing-redox-enzyme-family-protein
MQSINTTSAFRKTLEESVRNHPVLTFNLWLEKKEHKMEREDLLLWLRQEYFVSVDFVNWFLNTASICDSVEAKIVLVSNIWEELGEGNVENSHVFILKKFLSDMGEVVHEKHVLPETTSYLNLMQKITTSDFYSALGALGPANEYLLKLEYSRMFKSYLNLRERIILPEGKFFQVNLNADESHAEKLFRLIEVVADTEEKRNRVMEGSQLALDARLVFYEGLTTFQGL
>NZ_CP011410.1|WP_001038601.1|1673861_1674986_+|D-alanine--D-alanine-ligase
MNKMTPTVLVYADLHEFEGNFPEIYKQEWESKKSVDAILELLNEVGESVELVVTPNELLEKLKCYCDLDFSKRPVIFHLMEGFCSRNRESLIPAVAELFGFPHTGSDSYSQNVSLDKNLTRIFAQSIGVPVASGFWIRSKDVLFKELLQLECNSEIKKRFSFSKGNELSLKNFSFPAFIKPAGEGSSLGIGEKNIIYSFEELNTLLSEAPEIFFPYLLEEYLTGNEYTISVIGSATFGYKVSSAGRLILREDLKVEDVYGEKTKSKSIMPETLVFDCPKDLEVIIQQQSVLFCESLGTSGPARLDWKLDSLGNPFFLEMNLTPGLSPFYSTFPICYRHSLGDEKNLFQEILKIARLDFETDRFLYSKNKIRNLI
>NZ_CP011410.1|WP_001097878.1|1672618_1673869_+|KamA-family-radical-SAM-protein
MNTSHSFVQKSKGESFINRSRLFSSFDWTDYKAQLQNRVKGFELERYFDLTESEKIGIENTIRLNVSATPYYISLADPEDPNCPIRKMILPREDECIFSPEESPDPLHEERLSPVKGLTHMYPDRVLLFTNHECSVYCRHCMRGRKVSDSKERMLTEDLEICFDYIKSHPEITDVVLSGGDPLNLSDSKIDWILERLEKIEHVKICRLGTRNPVTLPFRVTFDLCNIIESHNTDRLSIFCNTQFNHSKECTPEAKEAILKLLKAGVNVGNQCVLLKEVNDSGQTMLELHKKLLELRVRAYYMYDPELIPGSRGFRTPLAKGIEIIEFMRGKIGGMGIPQFVNDLPGGGGKITLTPNWYLGFYKPERIHVFKSALRGTYHFSPEPIDSKMEEFYPEISLEIWERVFSNSFGIYKSNE
>NZ_CP011410.1|WP_000215704.1|1671860_1672535_-|HAD-family-hydrolase
MTVFSVESLQALAFDVDGTLFSSEGIILEVYRDSILNFSKTSGIQIELPSRDRIMAEIGKPVKTIFFNLLLQLNEEQRDSISDSVLRFLCDRIKKGEGEFYPNVLETIEILAQKGYRILAASNGRKPYIQTILEVSGILPKFEPILVLDNKRIRTKAEILEEYIKLYHLKPNQILMIGDRLSDHEAARQNGCPFAFCSYGHAPEGEIPDFDLKLKNISDLNEVL
>NZ_CP011410.1|WP_001113397.1|1671007_1671817_-|GerMN-domain-containing-protein
MPDSEKRKNIIFILTGIIFTLVLLDKSTGSGFSISNEGFNFNNIGKLTPKPYSSSKENFNHKEIMDQAEEEILEELLQNGDIQTSTDSSNSIEEDLNEDVPVLEPPIFSMDSTNEPDFPIPSEKGELSLFFLKFYGKGSKSHSRLVKVLRLSKGGDRVKLILNSLIAGPVSQEKEKGILNSIPQSLRYDDNYRIEKGILKLSLSSDLEKEAGPEILKDRIDQLIYSLMENLPIQGVQLKINGKFVRSLGGEGLPLPSLLTKNPRKIVVF
>NZ_CP011410.1|WP_001239790.1|1669664_1670894_-|GGDEF-domain-containing-protein
MRLSLGNNQKIKLLARRVFFNPFPDDYLRIYQPDVRRATVIYFFFCIGISFLSFLLPDGASLLGKENQILVYSRLTVLLLSAFFAFLLIKWRPFFRRRIERYSILSSGVIVFSILPYVFLDPGRMGLYFHFYTTLVVSGNILLWLTGTTVVIFNGLFYFSLVLCTSLTGNKNVLQHDFANVLIYLFTGIFGNLLINFWRVMDHRAKKKLQKAVSKLRDKNIQIEKISKVDELTGLYNRRYLIEQFELFLKRAQRYRFSLAMIILDMDYLKEINDSYGHLAGDLSLRTISDVMKQRVRATDICSRIGGDEFCILLDAIKKEDLVQLCENLRMEVAEKELSYRTQKGSPVKITVSIGACIFGPGEEFSFDDIYHSIDSALYESKKKGRNRVSFIEPIRYFPREYPGTTAAS
>NZ_CP011410.1|WP_000173137.1|1669276_1669681_+|hypothetical-protein
MTLKTKNLRGTKVIRILNCILVFLLAFGACTKQVKEHIHVDTGVTVEVLGVHKYKLIAIGGASSTSVEENDTFKMKNTSCTAAKSIAARKLEELEPEQKNRLFFMETVDTKYIDDGAYCEITYHYELPAPKKQQ
>NZ_CP011410.1|WP_000146503.1|1667350_1668454_+|dehypoxanthine-futalosine-cyclase
MASIFSSQPTDRILEKALDGNRISPEEALALYREGDHLKIMATARSLREKILPHHYASYTMFRVVNYTNYCNVECSFCSFMDEIGNGKGYVLSVEEILEKMDYAVGEGADQMFLQGGVYPDLSFDYYLNVISAVKKKYPHMHIRAFSPVEIINLEKITGLPLKEVLQILKQTGLDSVPGAGAEILTDRMRNIISPKKATTEEWVRAMETCHEVGLPGSANIVFGSEETQEEVIEHLNVVRNLQDRTGGFLSFIPWTFQPQTKRFTVRAVPTQEYLKVLGICRIFLDNILHIETSVMVLGKGVGQLALTSGADDISSVVIEENVLRSYGLKTEKEAVKFLKEGGFTPKRRDLLYNYDRYENELIVDFV
>NZ_CP011410.1|WP_002068674.1|1666923_1667085_+|hypothetical-protein
MIIIASIRSKKPIYFIKKSRLQGLSFASGIILERLDRLKIETNLLLQPHLKNT
>NZ_CP011410.1|WP_001016365.1|1677400_1678513_-|acetylglutamate-kinase
MNHQEILLKLLEVTENTQDSFQFLKRFRSIEPEKFAVIYADSSTLMESAEALLYNLKLLHKLDLFPVVVLDKDGISYTNLFYRNQNKDDTPSILPGKLFRHPQDLAGAVRSALDEEKLPVFIAEEKGQVLFNFLTKLCSILRTKKLVHLYSRGGVYLKGNKISIFDVDSSIKPDPEDESILSICLELYKNVKDKDFEIAITSASSLLKELFTIKGSGTLLRRKNRIDFIEDPLTVSSEKLNLLIEKAFQKSLKKDFWNQKFAGILLESEFKGCALVKNTSFGTFLSKFAVDEIARGEGVGRDIWDELIYRFPILFWRARKENTISKWYMKVCDGMQKEGIWIYFWIGVQEIQVPNICSFLKNLPEDMSST
>NZ_CP011410.1|WP_000181054.1|1678528_1679779_-|N-6-DNA-methylase
MTNFKKPIPKKSLRLKSKRSDRKNFPNDPRQKQNPLKSEWDFSKPDSFEYHASCPDGLSGLLREEVIEAGLKIISENRGGIFFQGPAKALKEFILSTGIASGISISLKYWRVENPEDLYDQALQFPFEKILNSEHSLRIDSTTKDSLKDSRYATYKLKDAIFDRFRSKGKEPPKISREEPDFLFYLRSHSDHAKLSLGLNTRPLQQRGHGRIGGEAPIREILASALIRYSGWDAKSQLYDPFCGSGTVVVEAALKLLYGGHTNYRSLASSLPFQKLFGQPNFKENLNLSSEIKIFASDLDPKTLGLARLNAKNAGVDHLIHFFESDAKISENEEKISEGFIVTNPPYGVRLGTKEEAKETYLAWGKKLKDHFSGNVLAIVCGDTSLLGFLKLKKDKEQSLTIGKLKGKLVAYTLGR
>NZ_CP011410.1|WP_000677991.1|1679775_1680243_-|bacterioferritin
MKGNKEVLEILGEVLSAELTAINQYFIHAKMNKNWGFKKLADFMKRESIDEMKHADEVIDRILYLDGVPDLQRYMKINVGNNIEEILKVDLELEYAAVERFNRGIVIAVKNNDNGTRELFEKILISEEEHIDWIESQQEIIRQIGVENYLAQQIE
>NZ_CP011410.1|WP_000287366.1|1680389_1681508_+|thiolase-family-protein
MYSSAFIIDSELSHFGKTELDYHSLSYQTAIQLLERNSEFEPQFLIFAAMAPERYTGEVFVSARIKESLGLKNLFTIRTETASSSGASALHTAVYLLRSGAFQRGIIIATEVMSRLEREENNLLLGSVLSERQKGFAMSMAQGGGMIATRYLQQYGYDRRDLYLLSKKLHDNGLKNEKAHIKKNITEVEYFNSPMFTSPLCLYDISPLSDGSCAVLLSSEKTKSSRSLEIRGIGHGIGNLSNPPGDLSFSSSVTAFQGAYKEANLKPEQIQIAELHDAFTPFELIGAEDAKLFPRGSALRYVKEGKTHPEGQLPINASGGLKTRGHPVGVSGLAQIAELQSWMFKKERFQNGLALSIGGLGVNNFATILSKV
>NZ_CP011410.1|WP_002097198.1|1681521_1682553_+|glycosyltransferase-family-9-protein
MNEKILLIQTAFLGDLILTTSFFREVKKKYPNSYLTVVVNKGTESVLEANPYIDSLIPLDKKEFKKSIWKFFSFLRELRKENYTLCILPHFSFRSTLIGFASGAKERIGYETAGFSFLLTKKIPRPILGIHEVEKLFSLLYSKEEYSNIQKRPELYWKEESVFRIRELMKENRLEPGNYVLLAPSSVWETKRMPASKFRVLGERIFKETGKKVVLIGSKADLDLCEEVGSGYAINFAGKTNLPELSFLVSKAALVISNDSSPIHFASAFNIPTLAVFGATVPDFGYTPLADLSFISEIHGLTCRPCGIHGGRTCPEGHFRCMKEQDTNKMFEVAVQLEQGNVK
>NZ_CP011410.1|WP_000205137.1|1682549_1683839_+|aminopeptidase-P-N-terminal-domain-containing-protein
MTSYIYSERIEKVQKRLKDGEVLIVFAASHLIRNRDVEYKFRQDSDYYYLTGIEESDGILILKNSYKSIFVLPKDKDKEIWTGIRIGKEKAKELLGLDESFDTNEWESKLDEILLNQHTLFHFFGKNLVRDSKLIEWIYSLNQRSREGKFGPKRIETPDFLHWMRMFKSAVEIEALRESARITALGHVRLMRESKPGMFEYELEAILESEYLKHGAWGGGYGHIVASGENATILHYTSNNCQLKPGDLVLVDSGAEKGYYTADVTRNFPVGKKFSPEQKAVYEVVLKAQKEAVSNTKEGVEFASIHNQAVKTLVEGLKDLGLLEGSMDFILEQNTFKKYYMHRTSHYLGMDVHDVGSYYKDGASWSLQDGQVITIEPGLYFDPTDFTIPEKFRGIGIRIEDDVLVQGQNPVNLTSLIPKEIDEIESLKN
>NZ_CP011410.1|WP_000591544.1|1684190_1684754_+|DUF1564-family-protein
MIKKDQTSSQHIRNLRNEQKKSKFITDKKSISKRKRDSPSDLWIPRVKIPHLTRRISQFKSLKCTLHFLLKKNRNRLHSLFAQPEKEKTLYQETELELVRFSFRPNAADWAELRLVARYYGVSICNFFVMLLTFDENINKGSAKSFWKDSKNQKFQNSEILLIQLISSKRNTLFFSIITGLNTFHGF
>NZ_CP011410.1|WP_000583497.1|1685479_1686016_+|DUF1564-family-protein
MIIGTGNGMNIKKSKQPSKHLKLLKPNRFGKDRTEQKLQNFQKHLKKLGAPSDFNIPKELVSHLGKRIQKAGSLRLLLNQCIHKRPFLILVPKQTSRNKISYQEQKLELQRYSFRPFEDDWIELKRLSFLYGVSMCKMFVKLLLETDLYPESRYAENPILDKLEGDTGDPTLIQKTGS
>NZ_CP011410.1|WP_134795163.1|1688512_1688671_+|hypothetical-protein
MTQKIVKQKNKSISIFTQNDRIEFYHKSQSECKILLIPHNKILNLIVYTSIL
>NZ_CP011410.1|WP_000683304.1|1689330_1690512_-|amidohydrolase
MKHTLTSNRMDELIRYRRQIHKHPELRYEENQTSDYVINHLKELGLSFQDKIAKTGVVSLIDSGKPRKTLLVRADMDALPIFEESNQDYKSVHEGVMHACGHDAHTSILMGLATEIKENIQFILPKGKVLLVFQPAEEGGQGADRMIEEGILEKYNVDAALALHVWNHIPIGKIGVVDGAMMAAVDEFTITISGISGHGAMPQHTVDPIVVGAQIVNSLQTIVSRNTDPLDSCVVTVGSFHSGNAFNVIPETAELKGTVRTYSKKMFEEVPGKLERVVKGIASALGATVSIRYERTNQPTINDPKMANIVRKASLNILGEGSLTEENTKSMGGEDFSAFLMKVPGCYFFVGSRNEEKGFVYPHHSSKFDIDEDSLSIGLSVLKEAIKIYLEEN

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Crispr_ID: NZ_CP011410_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011410_9

3075927-3076016

Orphan

Consensus_repeat	Method
CGTCTCACTTCTAAACTCAATGCATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011410_9

>merge|NZ_CP011410|9|3075927-3076016|CRISPRCasFinder
CGTCTCACTTCTAAACTCAATGCATCACTTTTAGAGTCGCTCTGTGGTCGTTCGGGAAACTCAGCGTCTCACTTCTAAACTCAATGCATC

>NZ_CP011410|9|9|3075927-3076016|CRISPRCasFinder
CGTCTCACTTCTAAACTCAATGCATC	ACTTTTAGAGTCGCTCTGTGGTCGTTCGGGAAACTCAG
CGTCTCACTTCTAAACTCAATGCATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011410.1\|WP_001122024.1\|3069058_3070225_+\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341486
NZ_CP011410.1\|WP_000850110.1\|3088727_3089324_+\|LemA-family-protein	unknown	unknown	gnl\|CDD\|377192
NZ_CP011410.1\|WP_000670773.1\|3076068_3077532_-\|polynucleotide-adenylyltransferase-PcnB	unknown	unknown	gnl\|CDD\|130997
NZ_CP011410.1\|WP_001192257.1\|3063170_3065099_+\|NAD(+)-synthase	unknown	unknown	gnl\|CDD\|143594
NZ_CP011410.1\|WP_000567061.1\|3079046_3080003_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|234599
NZ_CP011410.1\|WP_000625244.1\|3077585_3078602_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP011410.1\|WP_000852854.1\|3088389_3088662_+\|DUF736-family-protein	unknown	unknown	gnl\|CDD\|133956
NZ_CP011410.1\|WP_000913344.1\|3062490_3063075_-\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
NZ_CP011410.1\|WP_001283360.1\|3080667_3081291_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP011410.1\|WP_000150993.1\|3068658_3068982_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	unknown	unknown	gnl\|CDD\|377300
NZ_CP011410.1\|WP_001170202.1\|3085981_3087352_+\|DUF389-domain-containing-protein	unknown	unknown	gnl\|CDD\|377221
NZ_CP011410.1\|WP_001083572.1\|3067893_3068646_+\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|381175
NZ_CP011410.1\|WP_000273875.1\|3067156_3067897_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_001278842.1\|3072679_3073000_+\|polymer-forming-cytoskeletal-protein	unknown	unknown	gnl\|CDD\|377376
NZ_CP011410.1\|WP_001050492.1\|3089486_3090857_+\|TPM-domain-containing-protein	unknown	unknown	gnl\|CDD\|224429
NZ_CP011410.1\|WP_001193516.1\|3088228_3088366_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000616385.1\|3073002_3074934_+\|single-stranded-DNA-specific-exonuclease-RecJ	unknown	unknown	gnl\|CDD\|273193
NZ_CP011410.1\|WP_000444199.1\|3082899_3085746_-\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|224588
NZ_CP011410.1\|WP_000823115.1\|3071239_3071959_+\|glycoside-hydrolase-family-25-protein	unknown	unknown	gnl\|CDD\|119375
NZ_CP011410.1\|WP_000623631.1\|3066343_3067042_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011410.1\|WP_001122024.1\|3069058_3070225_+\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341486	cd14864, Fe-ADH-like, iron-containing alcohol dehydrogenases (Fe-ADH)-like. This family contains iron-containing alcohol dehydrogenase (Fe-ADH) which catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. Its activity requires iron ions. The protein structure represents a dehydroquinate synthase-like fold and is a member of the iron-activated alcohol dehydrogenase-like family. It is distinct from other alcohol dehydrogenases which contains different protein domains. Proteins of this family have not been characterized.	8.36121e-118
NZ_CP011410.1\|WP_000850110.1\|3088727_3089324_+\|LemA-family-protein	gnl\|CDD\|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	1.20508e-75
NZ_CP011410.1\|WP_000670773.1\|3076068_3077532_-\|polynucleotide-adenylyltransferase-PcnB	gnl\|CDD\|130997	TIGR01942, pcnB, poly(A) polymerase. This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).	2.20032e-95
NZ_CP011410.1\|WP_001192257.1\|3063170_3065099_+\|NAD(+)-synthase	gnl\|CDD\|143594	cd07570, GAT_Gln-NAD-synth, Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases). Glutamine-dependent NAD synthetases are bifunctional enzymes, which have an N-terminal GAT domain and a C-terminal NAD+ synthetase domain. The GAT domain is a glutaminase (EC 3.5.1.2) which hydrolyses L-glutamine to L-glutamate and ammonia. The ammonia is used by the NAD+ synthetase domain in the ATP-dependent amidation of nicotinic acid adenine dinucleotide. Glutamine aminotransferases are categorized depending on their active site residues into different unrelated classes. This class of GAT domain belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to classes 7 and 8. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase forms a homooctamer.	8.74572e-83
NZ_CP011410.1\|WP_000567061.1\|3079046_3080003_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|234599	PRK00052, PRK00052, prolipoprotein diacylglyceryl transferase; Reviewed.	5.87493e-45
NZ_CP011410.1\|WP_000852854.1\|3088389_3088662_+\|DUF736-family-protein	gnl\|CDD\|133956	PHA01740, PHA01740, putative single-stranded DNA-binding protein.	0.000329196
NZ_CP011410.1\|WP_000913344.1\|3062490_3063075_-\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	1.76601e-43
NZ_CP011410.1\|WP_001283360.1\|3080667_3081291_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.53654e-08
NZ_CP011410.1\|WP_000150993.1\|3068658_3068982_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	gnl\|CDD\|377300	pfam04316, FlgM, Anti-sigma-28 factor, FlgM. FlgM binds and inhibits the activity of the transcription factor sigma 28. Inhibition of sigma 28 prevents the expression of genes from flagellar transcriptional class 3, which include genes for the filament and chemotaxis. Correctly assembled basal body-hook structures export FlgM, relieving inhibition of sigma 28 and allowing expression of class 3 genes. NMR studies show that free FlgM is mostly unfolded, which may facilitate its export. The C terminal half of FlgM adopts a tertiary structure when it binds to sigma 28. All mutations in FlgM that prevent sigma 28 inhibition affect the C-terminal domain and is the region thought to constitute the binding domain. A minimal binding domain has been identified between Glu 64 and Arg 88 in Salmonella typhimurium. The N-terminal portion remains unstructured and may be necessary for recognition by the export machinery.	0.00215375
NZ_CP011410.1\|WP_001170202.1\|3085981_3087352_+\|DUF389-domain-containing-protein	gnl\|CDD\|377221	pfam04087, DUF389, Domain of unknown function (DUF389). Family of hypothetical bacterial proteins with an undetermined function.	5.67518e-59
NZ_CP011410.1\|WP_001083572.1\|3067893_3068646_+\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|381175	cd11648, RsmI, Ribosomal RNA small subunit methyltransferase I (RsmI), also known as rRNA (cytidine-2'-O-)-methyltransferase. RsmI is an S-AdoMet (S-adenosyl-L-methionine or SAM)-dependent methyltransferase responsible for the 2'-O-methylation of cytidine 1402 (C1402) at the P site of bacterial 16S rRNA. Another S-AdoMet-dependent methyltransferase, RsmH (not included in this family), is responsible for N4-methylation at C1402. These methylation reactions may occur at a late step during 30S assembly in the cell. The dimethyl modification is believed to be conserved in bacteria, may play a role in fine-tuning the shape and functions of the P-site to increase the translation fidelity, and has been shown for Staphylococcus aureus, to contribute to virulence in host animals by conferring resistance to oxidative stress.	5.18697e-101
NZ_CP011410.1\|WP_001278842.1\|3072679_3073000_+\|polymer-forming-cytoskeletal-protein	gnl\|CDD\|377376	pfam04519, Bactofilin, Polymer-forming cytoskeletal. This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria. In the example species C. crescentus, two bactofilins assemble into a membrane-associated laminar structure that shows cell-cycle-dependent polar localization and acts as a platform for the recruitment of a cell wall biosynthetic enzyme involved in polar morphogenesis. Bactofilins display distinct subcellular distributions and dynamics in different bacterial species, suggesting that they are versatile structural elements that have adopted a range of different cellular functions.	1.96443e-27
NZ_CP011410.1\|WP_001050492.1\|3089486_3090857_+\|TPM-domain-containing-protein	gnl\|CDD\|224429	COG1512, COG1512, Beta-propeller domains of methanol dehydrogenase type [General function prediction only].	7.26338e-47
NZ_CP011410.1\|WP_000616385.1\|3073002_3074934_+\|single-stranded-DNA-specific-exonuclease-RecJ	gnl\|CDD\|273193	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ. All proteins in this family are 5'-3' single-strand DNA exonucleases. These proteins are used in some aspects of mismatch repair, recombination, and recombinational repair. [DNA metabolism, DNA replication, recombination, and repair].	4.05494e-72
NZ_CP011410.1\|WP_000444199.1\|3082899_3085746_-\|DNA-translocase-FtsK	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	5.32309e-146
NZ_CP011410.1\|WP_000823115.1\|3071239_3071959_+\|glycoside-hydrolase-family-25-protein	gnl\|CDD\|119375	cd06413, GH25_muramidase_1, Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.	2.19534e-116
NZ_CP011410.1\|WP_000625244.1\|3077585_3078602_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	5.85427e-40

>NZ_CP011410.1|WP_000616385.1|3073002_3074934_+|single-stranded-DNA-specific-exonuclease-RecJ
MIQSSPFSHGPGLKELHPAGLRPHFSPLQHRFYETHLREKSHPEHLLYHGLRELPSPFLLPDLEPALDLLKEFIQKEKKILLFGDRDCDGVSSTSLLGSFLKKIHRGELILKTSNEEDYGLCPAALDFVKRIKPDLLITLDFGTTNHIQIDELASIGIKVIVLDHHEIPERIPDCYLISPKRSDSIYPNEKICTSVLALKFIQAYLYSSLEEYNRATWIGDGNSLFSGFLIYRGKLLFQGDRQEAESKFSLTIQDESYSFQSSYPEREWFYQEFLKYPAILEQYLQNFDLASIGTVSDMMPLYGENRIIVREGCKILFKLHKKETSHREGLFQLLQLMEFADNRVTSKDLGWGLGPMINSAGRMNRTDVALNLLLEENPELAKSGAKELQKLNEERKERTKRNIFKVDSFLKRKKERTERSVLFCYEPDFEPGVSGIVATRLVEEYKRPVLFITPDHGHAKGSIRAYGKENVLNLLKKAESVFLQFGGHKEAGGFSLEIDKIPELAKLIFDNADNWLAEEQMTSTSEQTESLISLKPEELNPKIFQELSIFEPFGHENPIPLYSIKNAKIYHTKPMTDGKHVRFRILGAPESIQCLIWNRGKDFLELISKSVSLDLWGSLEESTFRSKTSLQFIVNYFQESEN
>NZ_CP011410.1|WP_001278842.1|3072679_3073000_+|polymer-forming-cytoskeletal-protein
MSDEQIDTVIGDDIHFRGKLKFNNSLKIKGNFKGTIETTGKLVVGDTGEVEADIQTGTLEVEGNLKGNVSANQKVAIRKTGKVIGDIRTPDLEIESGAKFSGNSAM
>NZ_CP011410.1|WP_000823115.1|3071239_3071959_+|glycoside-hydrolase-family-25-protein
MKRKFLFLLVIISFFLLGIGLYNALNSGKIWFVYPSTSQYPIRGIDVSNHQGKIDWTLVPKSEISFVYIKATEGRDFKDKSFHLNWKKAKANGFFVGAYHFFTLCKSGKEQAENFISTVPKEIDSLPPVVDLEFLGNCKERSSMKDVSNEIQEFLNRVDSHYGKKTILYLTYEFIDRYIGPNFQDHPIWIRDLFKHPNTFSNQRWILWQYKSRGNLPGISGPVDMNVLNGELKILTLTK
>NZ_CP011410.1|WP_001122024.1|3069058_3070225_+|iron-containing-alcohol-dehydrogenase
MPILPDWVHYTFPPKIHFEADCGYKVGNFVKNIGSRTVIFSTQQELENMDELSVIKTSLEKHIDGVILYDDIAKEPSPEELDTAAYFAKIANADCIIGYGSYESISMAKLIALLITNDIFAEDMINDRKLKLKKPIPLILIPTHPVFGLECSPISTILLGDEKITRYFSHELLFPELIIADPKISSFMSSMDISKVGVGILAAAVDTILSKFSTELTISSALRAIELLQKNLIPSIRDPKNVNYKNGLYAASLLTGIAQSSSSLGLCFALSLASSNITNLDIFQSMSILLPHVMEYNLTSSAGKYVMIARALDEDITNISVIEAAIKAVEGIRKIFIELKIPQRLSEYEVRKMDLPSIANLAASFPFLDSLPRELPKNEIETILIAAF
>NZ_CP011410.1|WP_000150993.1|3068658_3068982_+|flagellar-biosynthesis-anti-sigma-factor-FlgM
MTIDKIGGIGGSGYEPKRTAPVKKTESKETFDNVSISDTAKQKASEAKLQAEIQTITRKILSTPDDQDRSVKLKEIKEKLKNGDYDNLSPEVLNTIADRISETMLGQ
>NZ_CP011410.1|WP_001083572.1|3067893_3068646_+|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MNSEEESSEIPLEPGTLYVVSTPIGNLEDLTFRALRILKNTDRILCENSGHSKKLFRSYSIHTQCSTLYKDQSENPYLSILEELKEGKTFALVSDAGTPGISDPGSHLIRVVREKGFKISPIPGPSALTALLGISGWQANPFLFLGFLSEKKGKKRNQLYEWKEFEGLIMIFESVHRIGDTLNSIQEVFSDCEFLIGREMTKIHEEILHFSPFATKKPKEFASKGEFVVLINTNRKKMLKGSIGSADRIQ
>NZ_CP011410.1|WP_000273875.1|3067156_3067897_+|hypothetical-protein
MYFQIFRSTSLPILTFIWILFGCGMNTDVAQSPFIFISPVGVPQFLSILAVNEGITDTATKDTDFQSEPNSYKPEFLVRYYVTNAEPQFVGYNLYITTAAPSVAETLTSGNVYLENGVQPSFPHLASEASTSSSKLQTHRVLNQIPPPGVFPFIKCEIYTFTMRALLNSGIFSNPSTPVKMCSSSRPFLCPVGSSCNPAECNNSSCTTAVKQNCPVGTLCNPCTISGSEETGCICPTGVSPPGCNL
>NZ_CP011410.1|WP_000623631.1|3066343_3067042_-|hypothetical-protein
MISIRKLVIYSGISISLIVLVWILFSSEDSSEKERKSKEADSVALLLGGGSPSSGSGSSGGKTNESIFDSSFYKSGKGEYIESDKGEPKEADPNAADADNPVNPQTNKPYTNEEMERFSQLRERFPDNSLIPKKLSPAEKEAKRQEDSRIAEAARNVFARTATHDQIRSYYQNMEKQTQDRMDIINYLVDLQKGSGEEETEKKLNNIQESIKNQLQQVQKEKENAFKQAGIL
>NZ_CP011410.1|WP_001192257.1|3063170_3065099_+|NAD(+)-synthase
MQSVRLTSVSLKTKVFDFQGNLEKIKRVLELEKKSDLILFPELCISGYGCEDAFYFPRIWKKSWNSLIQLLPHTENKIIVVGLPIFQNPYLFNCAAVLCNGVVAGIVPKSNLASTGVHYENRWFTRGEESQENFIAPDGSTIPFGSLIFETDHFSFGVEICEDSWVLQKPSIPLAEAGTDLILSPGASHFAFGKQRIRRQIFQESSRRESNVYLFSNLCGNESGRLIFEGGSMIVQNGKLLSESERLFFGDFSLCSNEIDFEASQADRAKNFRPSGNRFSKTKSTEENKIYLGIEFPKRAPKVNKSLLEISVSKEEESYLDFTKAVALGLFDYLMYSNTKGYTLSLSGGADSSACALLVTAMKKIAKLELGENFFKSKGIPEESILCTLYQSTSNNSDRTKFLAKSLAKEIQSIHGDLTIDSEIQSISEKISKLTGISLRWDEHNLTLQNIQARVRSPIIWMLANLNGHLLLSTGNRSEASVGYTTMDGDSSGSIAPLTGVSKEFILKWLRFVSEGKDPILPAYPSIKEIVNSPPSAELKPPEDKQEDEKDLMPYPLLQKIEELFIVRGAGYSEIIQLLSEDSEIQNLPPKFLEESVKKYISLFHKNQWKRERLPPSFHLDDYGLDPKSSFRFPILSEDIEL
>NZ_CP011410.1|WP_000913344.1|3062490_3063075_-|orotate-phosphoribosyltransferase
MLKKELSMKQELLELIRTHVYRYSEQPFTLASGRKSRHYFNCKEITLVPDRLELLCKFIVEQHLGESGILLPHAFGGLTMGADPICYGISLEFRKQNKNVYPLIVRKLSKDHGTKKLVEGSTHLVKQCVVIDDVITTGGSTIQAIRSLRDCGIEVVQGVCILDRQEGGKDAILAEGVEMFPIFKKSDFGNLEHE
>NZ_CP011410.1|WP_000670773.1|3076068_3077532_-|polynucleotide-adenylyltransferase-PcnB
MKFLSNLFKKKIGSVEDILSHPDGKRYYRDAHLIRKNMIDEDAVKIIHRLNKFGFKAYIVGGGVRDLLLGRKPKDFDVVTNATPNQIKKIFNNCRIIGRRFKIVHILFRGKVIEVSTFRSLPDYRLGKAVEDQDYLIKRDNKFGTPQEDAARRDFTINSLYYDVRNDSIIDYVGGFEDIRNKVLRVIGDPDISFREDPVRMLRAVKFAEILGLNIEKTTAKAIRKHKTELEKASSSRMLEEYNKIFRTWKTSLIFQGMAEHGILEVLFKEAFDKERKKNSNFGEKFLETNIGKRLAIADKLLTEREEMTPHIFYSLIFSDLASEALQKENMHLVPAIKNSLELIFRRLETPKKDKDRLIKIFASQQRFLSTEDEKSSQNNFFRMKDYFYDAFMVFKIGAIAENDEKAIQSAFFWEISVRKRPTPVKKFNGARPNKSRNRNFQKNREEDRSNRREETQSSSESEKQNRKNQKENSQEDFSSEDSGNEF
>NZ_CP011410.1|WP_000625244.1|3077585_3078602_+|M23-family-metallopeptidase
MISPAKYDLKLTHSERLQVKILKFKNRFRKFKESGSKKISFLLVPHSHENVITIELNVFMAWFLGILSGLILILAFLFLSYLNFFYRPDQDLFQKSDENVSQYLYYDMLLQDAKKEIRGLERKTEQLNLVAWDEVPWKRILTYEVIPEFHLKKEIPDSETNLELYKNTVEGFAVQNIELFRIRQAFENAFDYLEERESILYALPRGRPLKPGVGFVSSTFGGRVDPFGLVILGEHHSGVDFASAEGTPIYATAPGVVVESGQSSGGLGRNIKINHLNGIFTVYGHCSQILVEKNQIVKRGDLIGLVGSTGKATGPHVHYEVHIGQDPPLDPAEFINIE
>NZ_CP011410.1|WP_000567061.1|3079046_3080003_+|prolipoprotein-diacylglyceryl-transferase
MIDRIPVPFLNPLFKFLFNREWDGPSTFSILMMIGFLTASYLLPKELKRRKLEPEHSDWLLLLGILGTLVGAKIFFVFEIWDQIFVETPGFDGKYIYPLTHWYGFPGRMSLWDNLFSGSGLVFYGGFLFGILFITLYMKYFQLDIASYLDAAVPSMAIGYAIGRLGCWVSGDGCYGFATNVEIPLLVFNYHGAHPSGVPVWNTPLIESIISFLFFFYFQFWARNQNFKKFSIGAQYLVLHGFARLLVEFLRVNKAVFPLMDPPAFVNIPNAEQNPEFLTQYYWHGFSQSQLVSIIIILVGAFFILKWKLWKKENTSNI
>NZ_CP011410.1|WP_001283360.1|3080667_3081291_-|class-I-SAM-dependent-methyltransferase
MSDPWTDRWNERYNKEEFAFGEQPNEYLKEQLEKLKIGTILFPAEGEGRNAVFAAKLGWNVSAFDISIEGKKKAFRLAEANQVKIDYQVGELQTLDYHSEQFDAIALIYAHFPAEIKSYYHKTLSQYLRKDGLVILEAFSKKHIHYVLKNEKVGGPRELEMLFSIDEIKSDFENYEIIELEEKEIELKEGLFHNGNGSVIRFVGRRR
>NZ_CP011410.1|WP_000444199.1|3082899_3085746_-|DNA-translocase-FtsK
MESKPKEFKPTWNLQNGKMILPYVLLFAGIILTLSLGSFDAGERGVEYNFFGRLGYYISYGMFFMFGAASFLPGLFTIGLGSLRLVKEEFELTNRLFSIPVFLLCYTVTLQVTGHVSTIPFASQGGFVGQLLSSGLEFVFGSTGKILIHLVFYFYGLILLLNESPLHFIGRILGTAGAKYKEGFKSGFGKRGESLGSLFQSAVEKFQKKESVPPWISTNTNEKNSLNQSYSLSNPHTHSYERNLGNKQPSELQNTLHSTFGKEGKLSDFLSKVDTGPTVTSKNSRIRFQNHGAFSGNFEEQGKVFRFESVSSSLSEKIREEKNFQKTPSRWEILDFRTSSFSNIISEKEPSVTLVVPSESEIKKEWNQTNPILQSEEIPDKFLFEEKEKVEQTDSGLENECYEEESVDSEENLSEEETLSSETSTEKDISENFKTSTISNSKEVSPNHTSNSSIHSLEKSEEKLELGLPFPPTTLVPEVKSKRSIYHVPLKSLKTTTTKIQDPLFKIEADKVARKIEEIIRQYGYESQVVSMERGPIITRYELTPPLGVKLGRITSLSDELRLYLAVKNIRIVAPIPGKSTIGIEVPNSIREDVFLGDILHQNLSLRPKKDLSILIGKDISGKLVGIDLNKLPHLLVAGTTGSGKSVCLNSMISSLVVHLSPEEVRFIMIDPKMVELTLYEDIPHLLMPVITDPKKATRALAWAIQEMEARYHSVSKLKCRDFKTYNEKVEQGAHRDGYKKMPYIVIFIDELADLMMVSGKDLEDAITRITQKSRAVGIHLIMATQRPSVDVITGLIKANCPARMAFHVAQKTDSKIILDQNGAESLLGKGDFLYKSPTAADLIRIQSPYVSEEEIEKIVEEARKFGKPSYVDFNLDEETESSVVDEGDEELFEQAWEIVRTDRKASASYLQRRMRIGYNKAARLMELMEERGYVSPQIGSKGREILK
>NZ_CP011410.1|WP_001170202.1|3085981_3087352_+|DUF389-domain-containing-protein
MQKKSSHNPEPNFWDLLAPLFEFINPLLHIRNDTDETGTIESIKRGVNFSGSALWTLIFAIFIASIGLNINSTAVIIGAMLISPLMGPIMGAGLALGIYDFELLKKSLRNLAVMTFLSLFTSALYFLISPLSDAQSELLARTSPTIYDVLIAFIGGATGIVAGSRKDKISNAIPGVAIATALMPPLCTAGYGLANWNFKFFLGAFYLYLINSVFIGISTLIFVRYLKFQRTVYTDPAVDKKIYRYVYLLSVCLILPSIYFAYDIVVDSAFKRNAKSYLENQFTFEKSKILSANIVRKGGEKKIEVTMIGETLSEDVLSQLKTILPKYGLEDTELKIIQSYRDSSQLNQQSGFSFQNEAGSKIQEEKIHLLENELRILKDKDHLAQSVAKEINVLFPSVDSFSLGDFLVQNVQDFSSSKEVTVLVKWKHQVGSIERKRLELFLKLRLGLENLQVLDL
>NZ_CP011410.1|WP_001193516.1|3088228_3088366_+|hypothetical-protein
MQTITTEWMNERIEILAEILADQLIEEIRKRALEKEKLPNQTEAA
>NZ_CP011410.1|WP_000852854.1|3088389_3088662_+|DUF736-family-protein
MAEYTLKEKKGSLFSNAAKEKETQPDYTGKVLLEGKTYRLAGWIRKSATGKNYLSLSLSEPNLEKKSEGSSVITVTDGNDFTDIEEDFPF
>NZ_CP011410.1|WP_000850110.1|3088727_3089324_+|LemA-family-protein
MKTKIDFKLFLITTLTLLVFSNCGYNTIQEEDEAINASWAEILNQYQRRSDLIPNLVNTVKGYATQEEKVLIAVTKARAGVGSIQADEKTLNNPELFKKYSQAQAQMTSALSKLLVIAENYPELKSNENFRDLQAQLEGTENRITVARNRYIQAVQKYNVTIRKFPNNLTAKFFGFETKPSFSVENEKEISKPPEVKF
>NZ_CP011410.1|WP_001050492.1|3089486_3090857_+|TPM-domain-containing-protein
MNLLKARMIQSVTIKILFSVCLLVCTAGIHLKIGNSHSTFIIEEWKAEDQIIPLLHSPVTDATFTLTKEQKVQLTNRLISFETKKGSQIAVLIVGSTGEWSIEEYALKVFEKTKLGRKGIDDGILIVVAIQDHKTKIEVGYGLEGTIPDAIAKRIIEEFMIPHFKNGDYFQGVSDGIDTLILKIDGEELPETNKIPKFFEVINKYSMYIFPSLILIILIITIFITSGIFGTIVLIGGGFFLILMLESIILLVIIFFPLIFFFLMASHLRKKIRIRRKSFITPTNWDYIIIAVFIILGIVSTIGLIGFGIFRGLISESTILGISILILLIFFFLMTGYLRKKIQRKSFWDYIIIAVFIILGIVSTIGLVGFGIFRGLISESMILGIPLILFFLIMGYLRDKIRRKSFWDYILFGTGTSSSGSSSRSSWGSSGSSSSGGSSWSGGGGSSGGGGASGSW

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Crispr_ID: NZ_CP011410_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011410_10

4086803-4086898

Orphan

Consensus_repeat	Method
AGGAAAGCGTTGTGTTGAGTTTTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011410_10

>merge|NZ_CP011410|10|4086803-4086898|CRISPRCasFinder
AGGAAAGCGTTGTGTTGAGTTTTCCAACGCGACCTGGAGAGCGACCCTTAGGGAGCGATGCATTGAGTTTGAGGAAAGCGTTGTGTTGAGTTTCCC

>NZ_CP011410|10|10|4086803-4086898|CRISPRCasFinder
AGGAAAGCGTTGTGTTGAGTTTTCC	AACGCGACCTGGAGAGCGACCCTTAGGGAGCGATGCATTGAGTTTG
AGGAAAGCGTTGTGTTGAGTTTCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011410.1\|WP_000958086.1\|4082174_4084004_-\|apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|234721
NZ_CP011410.1\|WP_000761375.1\|4087775_4088264_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_167545859.1\|4094373_4094517_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_001053082.1\|4089631_4090654_-\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176251
NZ_CP011410.1\|WP_001080166.1\|4085507_4086164_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|319895
NZ_CP011410.1\|WP_001062719.1\|4074722_4075919_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|236226
NZ_CP011410.1\|WP_000798179.1\|4089075_4089627_-\|LEA-type-2-family-protein	unknown	unknown	gnl\|CDD\|377000
NZ_CP011410.1\|WP_000682886.1\|4086205_4086577_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000086941.1\|4094677_4096150_-\|amidophosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236384
NZ_CP011410.1\|WP_000264551.1\|4091843_4092833_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371795
NZ_CP011410.1\|WP_000181227.1\|4090650_4090977_-\|(2Fe-2S)-ferredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|239278
NZ_CP011410.1\|WP_000695979.1\|4079063_4080452_-\|DUF1554-domain-containing-protein	unknown	unknown	gnl\|CDD\|369437
NZ_CP011410.1\|WP_000776815.1\|4092841_4093624_-\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461
NZ_CP011410.1\|WP_000478347.1\|4091370_4091865_+\|DUF3347-domain-containing-protein	unknown	unknown	gnl\|CDD\|378730
NZ_CP011410.1\|WP_033108066.1\|4076851_4077271_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_001983916.1\|4075987_4076563_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000468942.1\|4077302_4078418_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000250245.1\|4088273_4088609_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_001257925.1\|4084212_4085511_+\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NZ_CP011410.1\|WP_000931455.1\|4081537_4082026_-\|immunity-26/phosphotriesterase-HocA-family-protein	unknown	unknown	gnl\|CDD\|379725

Protein	Function_ID	Function_description	E-value
NZ_CP011410.1\|WP_000958086.1\|4082174_4084004_-\|apolipoprotein-N-acyltransferase	gnl\|CDD\|234721	PRK00302, lnt, apolipoprotein N-acyltransferase; Reviewed.	2.96719e-69
NZ_CP011410.1\|WP_000931455.1\|4081537_4082026_-\|immunity-26/phosphotriesterase-HocA-family-protein	gnl\|CDD\|379725	pfam15428, Imm26, Immunity protein 26. A predicted immunity protein with mostly all-beta fold and several conserved hydrophobic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI1 or Tox-HNH family. The protein is also found heterogeneous poly-immunity loci.	7.28327e-21
NZ_CP011410.1\|WP_001053082.1\|4089631_4090654_-\|zinc-binding-dehydrogenase	gnl\|CDD\|176251	cd08291, ETR_like_1, 2-enoyl thioester reductase (ETR) like proteins, child 1. 2-enoyl thioester reductase (ETR) like proteins. ETR catalyzes the NADPH-dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the 2-enoyl thioester reductase (ETR) like proteins. ETR catalyzes the NADPH-dependent dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the alcohol dehydrogenases in this family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. Candida tropicalis enoyl thioester reductase (Etr1p) catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis. Etr1p forms homodimers, with each subunit containing a nucleotide-binding Rossmann fold domain and a catalytic domain.	5.11295e-155
NZ_CP011410.1\|WP_001080166.1\|4085507_4086164_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|319895	cd16373, DMSOR_beta_like, uncharacterized subfamily of DMSO Reductase beta subunit family. This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.	1.29296e-38
NZ_CP011410.1\|WP_001062719.1\|4074722_4075919_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|236226	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase.	0
NZ_CP011410.1\|WP_000798179.1\|4089075_4089627_-\|LEA-type-2-family-protein	gnl\|CDD\|377000	pfam03168, LEA_2, Late embryogenesis abundant protein. Different types of LEA proteins are expressed at different stages of late embryogenesis in higher plant seed embryos and under conditions of dehydration stress. The function of these proteins is unknown. This family represents a group of LEA proteins that appear to be distinct from those in pfam02987. The family DUF1511, pfam07427, has now been merged into this family.	4.75264e-09
NZ_CP011410.1\|WP_000478347.1\|4091370_4091865_+\|DUF3347-domain-containing-protein	gnl\|CDD\|378730	pfam11827, DUF3347, Protein of unknown function (DUF3347). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 169 to 570 amino acids in length.	7.24276e-07
NZ_CP011410.1\|WP_000086941.1\|4094677_4096150_-\|amidophosphoribosyltransferase	gnl\|CDD\|236384	PRK09123, PRK09123, amidophosphoribosyltransferase; Provisional.	0
NZ_CP011410.1\|WP_000181227.1\|4090650_4090977_-\|(2Fe-2S)-ferredoxin-domain-containing-protein	gnl\|CDD\|239278	cd02980, TRX_Fd_family, Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:ubiquinone oxidoreductase (NuoE). TRX-like Fds are soluble low-potential electron carriers containing a single [2Fe-2S] cluster. The exact role of TRX-like Fd is still unclear. It has been suggested that it may be involved in nitrogen fixation. Its homologous domains in large redox enzymes (such as Nuo and hydrogenases) function as electron carriers.	2.97611e-18
NZ_CP011410.1\|WP_000695979.1\|4079063_4080452_-\|DUF1554-domain-containing-protein	gnl\|CDD\|369437	pfam07588, DUF1554, Protein of unknown function (DUF1554). A family of proteins identified in Leptospira interrogans.	1.56178e-49
NZ_CP011410.1\|WP_000776815.1\|4092841_4093624_-\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	7.4343e-73
NZ_CP011410.1\|WP_000264551.1\|4091843_4092833_+\|hypothetical-protein	gnl\|CDD\|371795	pfam11916, Vac14_Fig4_bd, Vacuolar protein 14 C-terminal Fig4p binding. Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. The C-terminal region of Vac14 binds to Fig4p. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.	0.00397853
NZ_CP011410.1\|WP_001257925.1\|4084212_4085511_+\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0

>NZ_CP011410.1|WP_000682886.1|4086205_4086577_+|hypothetical-protein
MKHSLLFFLSAQFILSGLFAESNPKATPCSKDVENFCSHRKSEDRLSQMQCLMEKESDLSTTCSDWLKLKKEEIRKSSEECSEDRSKFCKFVIPGGGRILRCLMNHESSLSISCKEMIKRHLP
>NZ_CP011410.1|WP_001080166.1|4085507_4086164_+|4Fe-4S-dicluster-domain-containing-protein
MNRKDFFKKGLARMLDFAQENATELVSGFQEIVSKETPPPAPKKTNTKKVKKQTEFLLPEQIKSNRKRKIRNVQFPPGALDETEFLKKCTGCGDCIYACPYSVLFPVFEENLEKHIPRMDVNLNACMLCKDWPCINSCKTGALIPLEGAPKFGQAKGIFEYCINSKTGESTCSNCRDSCPIEGVVNFQGNKPSFSKNCTGCGQCVSACPTFPRAIRIK
>NZ_CP011410.1|WP_001257925.1|4084212_4085511_+|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MRSSYFKIIGKTPLHGTVVPQGNKNEALPLLGAVCMVPGTVRISNIPVISDVLMLMEVLRHLGMEITEEEPGTYIFKHDGNLKNQLPEELCSRIRGAVTLAGPILAMTGRVFLPKPGGDKIGRRRLDTHLLALQALGASIEVFPDGYEIKADQLKGTDILMDEASVTGTENAVMAAVFAEGTTILRHAASEPHVQRLCHFLNSAGAKISGIGSNILTIEGVTSLKPPAKEHKIGSDYLEVGSFISLAAVTGGELMIRDVELEDIRMIRMVYSRLGIEVRPHENGILVPSDQKMEIIPDYHGATPKIDDSPWPGFPADMTSVALVTATQCKGTVLIHEKMFESRLFFVDNIIAMGAQIILCDPHRAIVIGHSRLYGQKVASPDIRAGMAMIIAALCAEGTSYIHNIGQIDRGFENIDTRLRALGARIERVNAD
>NZ_CP011410.1|WP_000958086.1|4082174_4084004_-|apolipoprotein-N-acyltransferase
MLTSISKIKINVLSMDTLHHRFQQFQKTIWFNIFCYLWTGIFSFLAFAPVSLTHFVWIAPFGFFWLSLKYHGKYKKLFFHGLLIGVVFYAISFHWIIHMAITFGNFPYVVAILILLFAGLLFGLKFPIFMMSFSFLSGKIGRHSVWVAGFCGLLSELIGPQLFPWYWGNLAAGNIILAQNAEITGVYGISFLVFIVSYTLFQSNPWHWKEIIHSKEKRKQYLRFITLPALLLLTFIVSGIFLFKKWENVKPVKSLNVLIVQPDAPLSFRDGREIKESIEALMARIEKLTDEGAVRLGKKPDLIVLPEAGVPFFSAHKTEITTKVRRMYWDRFDSLMFLLANRYKANVFFNEIDAGFKGAPSPRNLRYYNNNVLYDPNGDRRDSYQKKFLLMFGEYMPFDFLYELSQQTGRFEPGLTHNLIRYYTPRYYTLAEKEKSPKGRHLGWTDTETFNHEAVRSYYETTRTEVSETGKFLPLICYEVILPEFVREFRTAGNPEFIVNLTNDKWYGATTESDQHMELGRLRSIELRRWMVRSTNSGISANIDHLGRFVGNKKTGLMTAEALSETIDVIDSPPTFYTQYGNLIPWLMLFLTGIYYLNLLIGIRRGKSS
>NZ_CP011410.1|WP_000931455.1|4081537_4082026_-|immunity-26/phosphotriesterase-HocA-family-protein
MLNEVKYPFVPKSNRSLIPGQFWAIPLNNGKFACGRVIEVHPFETKMFLAGLVNWIGEVVPKENDLAGKQTIKQGQVHIKTIHETGSDGMIIGYRNLSLDKIEPDFFKSQDGYQSGTSKLMKGYQEIRPLTKDESDLYPTFSTWGYDVIRVLAEELSVSKKI
>NZ_CP011410.1|WP_000695979.1|4079063_4080452_-|DUF1554-domain-containing-protein
MKIKYKFAILSAFTLVFVACLNKSSGDDNAVLSGLISLISNEQGCVGLDCSKNRTLRSNQLQSGQSLQAAFPQGYLPYIFATSSFGAVHNGNFGGISGADAFCQSHIPSSVPSTGIYKAMIVDGVNRVATTVGPNSTVGQVNWVFQPNQQYRRADDGAIVMTTNGSGMFDFSNGARLENSFALKGESGQWTGLNSDWTTWTSGGVPMTCSSWTSSALNLFGLFGSSTSTDSEILKASASTGGNTTSSCSSTRTFYGPYNLGLVCVEQPPPPKYIFTTSSFGTVHNGNFGGISGADAFCQSHIPSNVPGTGIYKAMLVDGVNRVATTVGPNSTVGQVNWVFKPNQKYQRAEDGAIVMTTNGSGMFDFAGGARLENPFTQVKESGQWTGLNSDWTTWTSGGVPMTCSSWTSSALNLFGLFGSSTSTDSEILKASASTGGNTTSSCSSTRTFYGPYNLGLVCIEQ
>NZ_CP011410.1|WP_000468942.1|4077302_4078418_+|hypothetical-protein
MFHQADSKKNSILTLLKFQTFLFLFFFASYSTLKADDSTSLKKATLKDYTFQPYTQEGYFQAWNYSYRDDKIFIYATFLISNLGPGTKNCGISLVIHTLGEGTKFVTKEFSVKELSAEKGKFDLKIENNRMSLNSEGIEIQQDVENIKLFLSFKSDLKQGVSLSGGKHTVKDPSGFVQADMAFSFQSVWGYLIQDGKKKELLGTGGLEHLLTNYEVYKYSKRWELFRSINSKEFRFYTGGFLGNDSFPGGYFRTAALLNPEGKTILSGRIIKFEVLETAKEPFSGYDLPLKEKFYFEDDCSAEIIRKQSVGSIYVLSNISSVLRFFIRLFFAKPYQIYSLADLNVQCSNKNLSSDSLETFSGILSYYLINP
>NZ_CP011410.1|WP_033108066.1|4076851_4077271_+|hypothetical-protein
MKNTIDSNQEIWMKLISKKDDFIKIVSTLNEFYIPKVHFSKLDQGQKIRIQLVQKKVKNFEVFLKKRNDHEFIIFLKVGDQFTSWIHQDGIGEAKERFLMEGKTDHLVFKFPCIGDLYQKHCSIAQADEMKTLNGKDSA
>NZ_CP011410.1|WP_001983916.1|4075987_4076563_-|hypothetical-protein
MESDLLAIFWTEKIKLTQYIIQTTKNFSSKQLDFSVTPRESVRFFLQGMVAGDFFLRVSLPISVGISSILPIARQSEEEIEKDLVRLRDQLGSPALPIGIKEIITQSADELFFEDCNPELKPLFIRWKKILIRLEKTIQGLSTKDSLKYRYFSVIGIVSLPVAINYFEMQNLTWLRNGIMKIAENPNFPSQ
>NZ_CP011410.1|WP_001062719.1|4074722_4075919_-|NADP-dependent-isocitrate-dehydrogenase
MAKIKVKTPLVELDGDEMTRIIWKEIKDRFIHPYLDIELDYYDLGVEYRDKTDDKVTVDSAHAIQKYGVGVKCATITPNQDRVKEYNLKQEWKSPNGTIRSILDGTVFRKPIIVKNIPPAVRSWKKPITVGRHAYGDLYKDTELYIPEAGKVELVYTGKDGKEKQRALIHDFEGAGVIMGQHNLDKSILSFAQACFNYAISEKIDLWFATKDTISKKYHARFRAIFDELAKAKAADLKKAGIEYSYYLIDDAVAQLMKNEGGMLWALMNYDGDVMSDMVASGFGSLGLMTSVLVSPDGKFEYEAAHGTVTRHYRKYQQGETTSTNSVASIFAWTGALIKRGELDGTPDVVAFGHKLEKAVIDTIESGEMTKDLTLLCTDSNAKALDTFQFMEAIQKRL
>NZ_CP011410.1|WP_000761375.1|4087775_4088264_-|hypothetical-protein
MKLAEWFFVLSLLFAGLIYLFLLLVKRKEKDTSNSIVKYLLPKEDLNSSINRTSDSEDSRNSKMNVLEVFDYNGIKIMHENGIYTVNTGGEIEVYGSWQALPSRYQRMVKEMDHRATGEKKAGKYYMEILNGVYYVIFPDGKKHKYKRFEDIPEKIRKNLGY
>NZ_CP011410.1|WP_000250245.1|4088273_4088609_-|hypothetical-protein
MVQKIQFKTIIRIQLAIFILALFLSIGCYQKNTDADFYSFEDANTKLISAYESKDVICNTNRRLTAFVPGRSRKKDIDLCVSAVLAVSCESWASTSIDATPTTCKSIEFRY
>NZ_CP011410.1|WP_000798179.1|4089075_4089627_-|LEA-type-2-family-protein
MKNSKLRWIFLYLTLISLYSCSSLQENYKALQKCKFQVLSLETQKAEWLSFPPVPKIVFLAKIEIENPNETEVTLYKFDLSFIVPDNFEKEFLLAKIQSEEKIIIPALQKKTVDLQVETLFEKKMDRNLLQIVLGILQAGLAGKELEFKIQGNFEYDTILGSVRIPVNEKIPLKMGKKKGFEI
>NZ_CP011410.1|WP_001053082.1|4089631_4090654_-|zinc-binding-dehydrogenase
MNLPTTYKALELREYSENRNRANIVEKTIRPLKKGEVLIRMHSASINPSDLMFMRGLYGIKKKLPIVPGFEGSGNVVSSGGGFYASYLKGKNVACTASGRGDGVYAEYMITDAFNCLPIGKDLSLEQGACLYVNPITAIAMVERVQSLGIKALVQTAAASALGKMVVGIAARKGMKVINIVRKPEQEEVLKKIGAEYILNSESSNFERQLRILSKDLNATVCLDAVAGELTSRVLLAMPYGSRAIVYGALSEKEIPIHAGMMIFQDKKLEGFWLSTWVPQQTPYKIWKLSKELRSLAKKELKTDIASRFPLEKAVEAIDHYAVNMTKGKVLIQTSFAEGN
>NZ_CP011410.1|WP_000181227.1|4090650_4090977_-|(2Fe-2S)-ferredoxin-domain-containing-protein
MTNFYTKHVFVCENVRAEGERVSCGRSGSIQLLASLKKKMKDLSIEGKVRIQRAGCLDRCELGPVQVSYPEGRWFSLKTEEDVDIFLKYYIQSEQIQKIEHLIIKENQ
>NZ_CP011410.1|WP_000478347.1|4091370_4091865_+|DUF3347-domain-containing-protein
MFLFWRLEKMKKFLILIISILTFFSSCKKPDPAVTEQEKDILQQILMENESIHKFLMKEEEKIPDTNQLIAHVVELVSLNGGLKSQAEKMQNSLKDKETQDVEKFFQAYSSFSENLAESLKLAGGTGVFNRFYCPMVNKTWVSQGTKIRNPYAPEMRDCGDLVH
>NZ_CP011410.1|WP_000264551.1|4091843_4092833_+|hypothetical-protein
MWGPSTLNVEVCLDKEIKTRCKIGVSLGEPCPANCRQNLLHNEWSSEIRESCIAGEKMNAFAEGKAGINVGASAFLQALPFVLEEFISKGRVYLEILIYFLSIIEPEKVKEVIDSFSNKLLYKIIIYEYNIYQQTEDERKSLKKNASFLDLRENAYWGSLSPERICSFIAYCLKEAKDPEFASQFLTVLPSEAVSDLRNLAGLNVEEEKELYLSLKDGIYELPIQIPGIYRHILSLFEDDPEIFLILSTMEELVLRKQQIIESSHAILEKYKSGKLNHQSLFGDLSVLELEISMEILGIFEEKEILGRSEKNLIKELLFKHKHLKSEIT
>NZ_CP011410.1|WP_000776815.1|4092841_4093624_-|PhzF-family-phenazine-biosynthesis-protein
MKLRMLQIDSFAEKVFQGNPAAVCPLQEWISDEWMQKIASENNLSETAFFVLEGESYRIRWFTPLREVDLCGHATLAAAYHLFREGEVIGDKLNFQSLSGELNVFKKENILYLDFPSRKPEKVETPKEILNSFSISPKEVFKSRDYMLLYENENQLKKLEYSVEGVRELNTLGIIATCVGNDSYDFLSRFFAPSVGLYEDPVTGSAHCTLIPFWSERLGKKIMKAYQTSARGGKLFCEDLGERVRIGGTCVPYLDGWIEI
>NZ_CP011410.1|WP_167545859.1|4094373_4094517_+|hypothetical-protein
MDRVVGTKFHRGLVAIPTRLILRYNTCGVGYWLLIGSLLEHSTNRVL
>NZ_CP011410.1|WP_000086941.1|4094677_4096150_-|amidophosphoribosyltransferase
MSRIPDKSRIRRQAQDDKPKEECAIFGIFNSSEASNFTYLGLYSMQHRGQESSGIVSSDGEHLYRYAGMGLVAHIFTETKLKELQGNAAIGHNRYSTTGASFLRNAQPLRVESHLGAVSLAHNGNLVNSWELRSQLEKEGSIFQTTIDSEVIVHLMARSGETDFLSALSSALKKVRGAYSLVILTKTQLIAVRDPNGFRPLVMGRREDGSIVFASETCAFDITDTKYERDVEPGEMIVVDKNGMNSYYPFPKASPSLCIFEYIYFARPDSSIFGESVYKVRKNLGRFLARELPVPADVVIPVPDSANIAALGYAEESGISYQSGLIRSHYIGRTFIEPDQKIRDFGAKIKYNVVRNVVEGKRVIVVDDSIMRGTTSRKIIKMIRNAGAKEIHLRVSAPPTISPCYYGIDIPTHNELIAATHTIEEIRKYLRVDSIAYLSVESMNRAVMDHKGGGFCNACFTAQYPVEFQSELGNQKSLFKEYQVEERVVY

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Crispr_ID: NZ_CP011410_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011410_11

4252934-4253028

Orphan

Consensus_repeat	Method
GAAAACTCAGCACAACGCTTTCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011410_11

>merge|NZ_CP011410|11|4252934-4253028|CRISPRCasFinder
GAAAACTCAGCACAACGCTTTCCTCAAACTCAATGCATCGCTCCCTAAGGGTCGCTCTGCAGGTCGCGTTGGAAAACTCAGCACAACGCTTTCCT

>NZ_CP011410|11|11|4252934-4253028|CRISPRCasFinder
GAAAACTCAGCACAACGCTTTCCT	CAAACTCAATGCATCGCTCCCTAAGGGTCGCTCTGCAGGTCGCGTTG
GAAAACTCAGCACAACGCTTTCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011410.1\|WP_001167091.1\|4249361_4249598_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000033742.1\|4257948_4258398_+\|OsmC-family-protein	unknown	unknown	gnl\|CDD\|224678
NZ_CP011410.1\|WP_000353566.1\|4246913_4247444_+\|DUF1564-domain-containing-protein	unknown	unknown	gnl\|CDD\|284922
NZ_CP011410.1\|WP_000472898.1\|4252240_4252726_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000055097.1\|4258786_4260220_+\|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|109787
NZ_CP011410.1\|WP_001116789.1\|4244003_4246085_+\|AsmA-family-protein	unknown	unknown	gnl\|CDD\|379224
NZ_CP011410.1\|WP_000043664.1\|4264723_4266292_-\|chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NZ_CP011410.1\|WP_000837582.1\|4250191_4251814_-\|caspase-family-protein	unknown	unknown	gnl\|CDD\|334197
NZ_CP011410.1\|WP_000671768.1\|4260327_4261659_+\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|277335
NZ_CP011410.1\|WP_000644921.1\|4246108_4246531_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000619176.1\|4243071_4244025_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP011410.1\|WP_001128566.1\|4255655_4257248_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NZ_CP011410.1\|WP_000121286.1\|4263141_4264005_-\|S-methyl-5'-thioadenosine-phosphorylase	unknown	unknown	gnl\|CDD\|350161
NZ_CP011410.1\|WP_000580059.1\|4267892_4268666_-\|cobalamin-binding-protein	unknown	unknown	gnl\|CDD\|238564
NZ_CP011410.1\|WP_000830855.1\|4261665_4262487_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223999
NZ_CP011410.1\|WP_000127308.1\|4242073_4243075_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP011410.1\|WP_000200398.1\|4247532_4249365_-\|DNA-mismatch-repair-ATPase	unknown	unknown	gnl\|CDD\|213250
NZ_CP011410.1\|WP_000499820.1\|4249776_4249983_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011410.1\|WP_000350173.1\|4266867_4267698_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|185333
NZ_CP011410.1\|WP_001284345.1\|4253741_4254743_-\|ketol-acid-reductoisomerase	unknown	unknown	gnl\|CDD\|235491

Protein	Function_ID	Function_description	E-value
NZ_CP011410.1\|WP_000033742.1\|4257948_4258398_+\|OsmC-family-protein	gnl\|CDD\|224678	COG1764, osmC, Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism].	3.96717e-21
NZ_CP011410.1\|WP_000353566.1\|4246913_4247444_+\|DUF1564-domain-containing-protein	gnl\|CDD\|284922	pfam07600, DUF1564, Protein of unknown function (DUF1564). A family of paralogous proteins in Leptospira interrogans. Several have been annotated as possible CopG-like transcriptional regulators (see pfam01402).	4.56034e-91
NZ_CP011410.1\|WP_000055097.1\|4258786_4260220_+\|NAD(P)-binding-domain-containing-protein	gnl\|CDD\|109787	pfam00743, FMO-like, Flavin-binding monooxygenase-like. This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.	3.73834e-85
NZ_CP011410.1\|WP_001116789.1\|4244003_4246085_+\|AsmA-family-protein	gnl\|CDD\|379224	pfam13502, AsmA_2, AsmA-like C-terminal region. This family is similar to the C-terminal of the AsmA protein of E. coli.	1.37887e-08
NZ_CP011410.1\|WP_000043664.1\|4264723_4266292_-\|chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	2.87576e-36
NZ_CP011410.1\|WP_000837582.1\|4250191_4251814_-\|caspase-family-protein	gnl\|CDD\|334197	pfam00656, Peptidase_C14, Caspase domain.	8.69787e-16
NZ_CP011410.1\|WP_000671768.1\|4260327_4261659_+\|alkaline-phosphatase-family-protein	gnl\|CDD\|277335	cd07389, MPP_PhoD, Bacillus subtilis PhoD and related proteins, metallophosphatase domain. PhoD (also known as alkaline phosphatase D/APaseD in Bacillus subtilis) is a secreted phosphodiesterase encoded by phoD of the Pho regulon in Bacillus subtilis. PhoD homologs are found in prokaryotes, eukaryotes, and archaea. PhoD contains a twin arginine (RR) motif and is transported by the Tat (Twin-arginine translocation) translocation pathway machinery (TatAyCy). This family also includes the Fusarium oxysporum Fso1 protein. PhoD belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.24453e-51
NZ_CP011410.1\|WP_000619176.1\|4243071_4244025_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.13546e-129
NZ_CP011410.1\|WP_001128566.1\|4255655_4257248_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	5.18097e-31
NZ_CP011410.1\|WP_000121286.1\|4263141_4264005_-\|S-methyl-5'-thioadenosine-phosphorylase	gnl\|CDD\|350161	cd09010, MTAP_SsMTAPII_like_MTIP, 5'-deoxy-5'-methylthioadenosine phosphorylases (MTAP) similar to Sulfolobus solfataricus MTAPII and Pseudomonas aeruginosa PAO1 5'-methylthioinosine phosphorylase (MTIP). MTAP catalyzes the reversible phosphorolysis of 5'-deoxy-5'-methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1-phosphate. This subfamily includes human MTAP which is highly specific for MTA, and Sulfolobus solfataricus MTAPII which accepts adenosine in addition to MTA. Two MTAPs have been isolated from S. solfataricus: SsMTAP1 and SsMTAPII, SsMTAP1 belongs to a different subfamily of the nucleoside phosphorylase-I (NP-I) family. This group also includes Pseudomonas aeruginosa PAO1 MTI phosphorylase (MTIP) which uses 5'-methylthioinosine (MTI) as a preferred substrate, and does not use MTA. NP-I family members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	5.09349e-134
NZ_CP011410.1\|WP_000580059.1\|4267892_4268666_-\|cobalamin-binding-protein	gnl\|CDD\|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	1.92473e-90
NZ_CP011410.1\|WP_000830855.1\|4261665_4262487_+\|alpha/beta-hydrolase	gnl\|CDD\|223999	COG1073, COG1073, Hydrolases of the alpha/beta superfamily [General function prediction only].	1.4417e-12
NZ_CP011410.1\|WP_000127308.1\|4242073_4243075_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.20273e-144
NZ_CP011410.1\|WP_000200398.1\|4247532_4249365_-\|DNA-mismatch-repair-ATPase	gnl\|CDD\|213250	cd03283, ABC_MutS-like, ATP-binding cassette domain of MutS-like homolog. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal domain with a conserved ATPase activity that belongs to the ATP binding cassette (ABC) superfamily. MutS homologs (MSH) have been identified in most prokaryotic and all eukaryotic organisms examined. Prokaryotes have two homologs (MutS1 and MutS2), whereas seven MSH proteins (MSH1 to MSH7) have been identified in eukaryotes. The homodimer MutS1 and heterodimers MSH2-MSH3 and MSH2-MSH6 are primarily involved in mitotic mismatch repair, whereas MSH4-MSH5 is involved in resolution of Holliday junctions during meiosis. All members of the MutS family contain the highly conserved Walker A/B ATPase domain, and many share a common mechanism of action. MutS1, MSH2-MSH3, MSH2-MSH6, and MSH4-MSH5 dimerize to form sliding clamps, and recognition of specific DNA structures or lesions results in ADP/ATP exchange.	2.67443e-91
NZ_CP011410.1\|WP_000350173.1\|4266867_4267698_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|185333	PRK15435, PRK15435, bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada.	4.04201e-51
NZ_CP011410.1\|WP_001284345.1\|4253741_4254743_-\|ketol-acid-reductoisomerase	gnl\|CDD\|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0

>NZ_CP011410.1|WP_000472898.1|4252240_4252726_+|hypothetical-protein
MFKIYYLVSKNNPLEFWNLKITENSFTVISCDKADLHTETEETQVFETNEICFQKAEKLLREKLNSGYQGVAPKTLQRIDRLEDQLGSSAMKYRACDLGSEKEKKIISEYHKILNILFQRDLIHFWPQRPDHDSCLPDELMPKFYRDHRDRQIGKRNRLQN
>NZ_CP011410.1|WP_000837582.1|4250191_4251814_-|caspase-family-protein
MKSKLSAIVICSILFFATDAFAQKRYGLIFGTNYTGNKAGIPELNLCEADASYLNDEIRKVGNFDEVKIVLGKEVTKDNIEKEIKALAKKAGDNDTVLLYFSGHGAFQRDASAKNGMRNLIICYDRPHLPDDELNKYLEKIKSPKTVFIFDCCFSGGIAKKGKSTRGSADVPIPEGSNGTVKQDAEDFFFQDKAIISSADDNQTAIEVGGSINHGIFTYNFGRALGSADLNKDNVVTALEAFFKSKEETVQMAKKFQHEQVPQISGNASGIFLSGKKNPEPPKPVDPPKPPAPSAEPEPDPVKPDPSQPVVTPEEPPVVPTNERGDLVLKTTIIQDRAYGLSDLPPDILIFAKKKRKGNRNVKVYIDDQEFSSTVTATSSNFWGAVKRQGQLIPGNIYTITLSKVPAGVHKITIKADDYPEIQETFAVLPNKKNELPINVSMSGFGAIQGKVFYKTLDNPVSNQPIFMPTISSVTGIQKLNTDSEGNFWFTNLKPGDYEIKASFAEDLNLNNSMINVREGDVTKVDVILNVKMPSTKTKY
>NZ_CP011410.1|WP_000499820.1|4249776_4249983_+|hypothetical-protein
MFYPEMDPDLKSSFLSIDKTVANLINNTILPEAGLKAGNLLNANQMKKLKEIRKRRFRSNEWKNFLKD
>NZ_CP011410.1|WP_001167091.1|4249361_4249598_-|hypothetical-protein
MQIRMINNTGRRTGRFVTYEYGTDLFGYVYVDKIKGKDRGKLVSRWVMPDLGSLVRLLDFEIYKRENEHYENISSVIG
>NZ_CP011410.1|WP_000200398.1|4247532_4249365_-|DNA-mismatch-repair-ATPase
MTSFTRIDRLKRRAEKLNKLHDKISVLLSRLSLFRLIFFSVFLLWISIFYYLHSSIFYHLPSLVFLFLFFFFVRRYKKTLLTRKKIQLWIFVLERESARISIKGFGKKFGTQIVLEKVSPLARDLDLFRENGLFSWLDTTFTSNAEQKLIALLDLEDSSSYNNRENVLLRQSIVRSISEKTLAIPKILRLASYLKENQDVFQARTKTETKSIRDENTSKFWESYPWLKKIYRPITILVLAFIPANVFLGIPFPASVLFLNLILFGLYRSRSLDIFRQYYSISGSISGLQKILIYLKGLKIRDKNGRFLLEDTSKDELRSAYKDLDLILKRVSLTEAPLLHLILNNLFLYDLWVLQKISKWKEKHSVLLEKSIEDLTLFDSLFSFANLKWMFPDYCFPEILSENSKEGISGKGLFHPLIPSDSRVSNPLDFIEEQNVVLITGSNMSGKTTYLRTIGVASILSMAGGPVPASKFSLPVLKIHTSMRNEDNLEEGISFFYAEVRRLSEIVKKIRDKNSSHLVLLDEILKGTNTRERSLACKGILKELKKNRTIVFVTSHDLELAKVEGVILKHFQEEVLDGTMYFDYKIREGLVETSNALRILVQEGLDLDFT
>NZ_CP011410.1|WP_000353566.1|4246913_4247444_+|DUF1564-domain-containing-protein
MDILLFDDGQKIESALVEGSIGTDSLLVPNNYWNCLNFQERKALRGKLPILLRKYSKQIASMKRLHYKAGKIKYNRDVGKMKKFSVRVHTGVWATLGVLAAAHGVSRCYLFNYMLWLEELGEEENFFVKTLNQGVPSFHWTYKMIWKIDRRQNLISRELKFEPNPMTNQYPYYLRS
>NZ_CP011410.1|WP_000644921.1|4246108_4246531_+|hypothetical-protein
MKAKLFIRIASALMLVFTLGHSFGHFTRYETSDPQALSAISIMQQTKIPMEGVTKTYDQFYTGMSLNLSIVLISLTVLLWILSNFSESNPQAVRKLLIPTLFCISCFGITGFIYFFLIPAVVASLGALSILVGIVLLGKN
>NZ_CP011410.1|WP_001116789.1|4244003_4246085_+|AsmA-family-protein
MPFSNRLDLMKFFKRIQEFLYTYRIRFLAIILIQIIAVISFTLVPLLIREDFYKDFILTAIEQKTGLEVKVGSSDLVLFPFPGIELKEVQIRKEELVIGISDRIKVDISWFGLLGQKVEIRDVYISGGKINLHKNKDGSVDLIEFFQQDTEDSENSNHNHTIRIFDPSSTVESSSFISPKEIFKVGLKNVEIENFYIHYQDDTHRRTYEIYLSNSALNISFYGNNFVLTLQGKLDGQSFQIYGSTNLDEFPTTYENSKFQSTISLDKCSLSIFRDLLTIFPNADFSKTILNGTIKIDKVPNRSINFNVIAQAKNFAYKGGNPFGDIKVNMEFRLDLPNKKLEFPYISILWPGIAEGNAKGTVLWNYKTNVSFQVTANYLDYHSALRLGKLFEFTKKFDDPNRPNGVFYFSVDLKNVYALKHRIPVLKAELKYSYPWIHIPSFHAYIYNGEILGKSKIDPFTSKFEVQGEAYRIQSDRILMPYVNDPIINGDMFSRFNFVTEVHNRSSDFTTEFFRNMEGSGNLQVLNGELLGYANFMIPVLNTLGKIISFNGIDGRKVEFSSLKSDFTIENNHLHFQNLKLQGKGLEADGKGNISFEKNIDVLINLRLGGNIVGRVLKIPIIYKGVFKQSIPYIDPIWLGSVFAGSTILAPFFTFAGGPYGGGIAGSVVSEYVRDAWEGLKGLFSSKEDKKKK
>NZ_CP011410.1|WP_000619176.1|4243071_4244025_+|ABC-transporter-ATP-binding-protein
MIRIENLTISYYTKSGFGLKKSRIVAVDGVNLEIGKNEIIGLVGESGCGKSTLGRSLVKLLKPEFGSIYFEGKEITSLSSSEFFPFRKNIQIIFQDPYSSLNPRMTIAEILMEGLEIHEKTSREEAETKIKKILEKVNLSSDILSRFPHEFSGGQRQRIAIARALVLKPKFVICDESVSALDVSTGTQVLKLLVELKNEFGLSYLFISHDLGVVKSISDRIAVMYLGKIVELGNTKNIISSPAHPYTKALFQSTFDVYDRKKNRIPLKGEIPSIVNKPTGCHFHTRCPIARDLCKSEVPVWKEIRNGQKVLCHFPID
>NZ_CP011410.1|WP_000127308.1|4242073_4243075_+|ABC-transporter-ATP-binding-protein
MTASSLLQVKNFSLDLLSENQWLPVLQNLNFEVKSGEILSLIGESGCGKSLTSLALTKLVPSNISKVKSGEILYQGKDLLKLSSEELRKLRGKEIAYIFQEPFAALNPLLKIQDQMIEAYLMHVSQNRKEAIEKAEFLLASVGITDIQQRLGSYPNQMSGGILQRISIAMALMCDPSLLIADEPTSAIDVTIQAQLVELLLNLQKQNRMSILFISHDFGLVGTIADRIVVMYAGRIAEIGDTDSVIDSPNHPYTKDLLKSIPSLAKSVEDLQPIQGIVPSPNQYPLGCHYSTRCQIAIDSCKESKPDLFPILQSDLKPHLSACFLAKDPDKSS
>NZ_CP011410.1|WP_001284345.1|4253741_4254743_-|ketol-acid-reductoisomerase
MANIYYDADCDLNSLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLKEGSKSIQDAKNAGFEVYSVSEASQKADIIQILAPDTIQADLYKKDIEPNLKKGDALVFSHGFNIHYDFIKPPKEVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAIYQDSSGEAKKRALAHAAGVGGGRAGILETSFREETETDLFGEQVVLCGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIYEGGLARMRFSISDTAEYGDYVSGPRVIDPGVKQRMKEVLNDIQKDKGAKFATNWMAETKAGYPNFKNMRDKNASHPIESVGKKLRSMMKWLSK
>NZ_CP011410.1|WP_001128566.1|4255655_4257248_-|methyl-accepting-chemotaxis-protein
MPLKKETKRKTDEEIIASGPTYINWIRFGLILLFYTSILINWKRTNSIQNILYLSGTTAMFLNFIYSFYKIRKTGSISHTLSKVFLLVDVLVQLVVMMGATMDHPDFTTGVVKSPILYGISYMYIVSSGLLLVPNFVLWIGFLSGGAQALAIFTATRYGLILTEQKKLANSLGYASVSEQITKILFVFACAVIVRILVKLFMRLRENSRYRQEALEESHKLIAQRSSKMKESAQYLKDSSKNLKSFMDDLSVLVSTQASSFEEISSTVEQFQSQTENSSYNVKNQFRNIESLILHSNNLKSIIEKISNFNQTLDQSMDKVRKSGTMVTKFVEELSGSLSSLGDSFRSVGEVNRIMSEVADRTNLLSLNASIEAARAGEAGRGFAVVAQEVSKLAESSAGNADLISKIIRDSSNHVQMGRESAETTAGHVKEQDTLIQDLFVRFDEFSNLFYEQRKINSEFFSTLDRLRSLSSEIELASSEQKMGLQGIVEAISLLQNSMESLVTKSENLSVVVRELETQSDTLILAETNT
>NZ_CP011410.1|WP_000033742.1|4257948_4258398_+|OsmC-family-protein
MSKHKISLSWKKGLEDFKYDSYDRTHSIQYEGGQKLHGSSTPETYGKAEHTNPEELLASSVCSCHFLTFLAIASKSRHIVSSYEDNAIATLEKNEEGKMVVTKIELYPKVTFEGDKIPDLDTLVDLHEKAHKNCFIANSIKSKVIIQPR
>NZ_CP011410.1|WP_000055097.1|4258786_4260220_+|NAD(P)-binding-domain-containing-protein
MSLLPTVCIIGAGPSGIAVCKALKDKGIPFECYEAGSEVGGNWKFKNDNKMSSIYKSLHTNTHKDKMQYKDYPMPNSYAAYPDHQKISEYFINYVNHFGFRDHIFFKTPVTHVKHEEDGTWSILTQDGKQKYYDVLIVSNGHHWSQRWPKPDFPGKFTGDIIHSHSYIDPNKPIQLTGKRVVILGMGNSAMDIAVELCRPGISSKVFLAARRGAYIIPNYLFGKPLDKIATLFPVHTPFWLKSLIIKFALKLGVGNVEDFGLQKPDHKPGAAHFTISQDILVRLGRGDIIPKPNIESYNGNKVKFVDGSEEEIDVIIYCTGYDVKFPFFDENFLSAKDNHLPLFHRMVKPEFKNLFFVGLFQPLGPIAPLSEFQGKWISEYLVGNYEFPSEEKMNQSIEKYESKMKRRYITSARHTMQVDFEVFLYDMKSELKKGIKRAAKNGNKLPVPALAQNKSILSNDISVKRFKNKTELFSEI
>NZ_CP011410.1|WP_000671768.1|4260327_4261659_+|alkaline-phosphatase-family-protein
MKFQISKYKTIFYFFSLFFNHILNAESAKIVSGPILGYSTLKEVLVWVQTDQKSNVKLEYSEIGNSKNKFFSEEIQTKSEQGFIAKLIANQVEPGKKYNYNILIDGKKIPAKHSQVFQTQPFFAYASNEDPPSFSFALGSCSYINEPEFEVPGKTYGGEYFIFNSIFSKKPNFMLWLGDNIYLREPDWDSRTGFFHRYRQQRGIPELAPLFASVHHYAIWDDHDFGPNDADSSYWMRETSEEMFKLHWGNPNYAKEGIYGSFIWGDVQFFLLDNRTFRTANNNKMISPRQILGEKQFQWLVNSLAYSKATFKFIAMGGQFLNPNPIFENYATYLEEKNKILSAIQDLKVKNIIFLTGDRHFTELNFLKEKDISIYDLTVSPLTSKPYSPDSEKNPLRVEKTLVDKRNFGTISISGKRNERKLVLQIFDVYGKELWKKEILSNP
>NZ_CP011410.1|WP_000830855.1|4261665_4262487_+|alpha/beta-hydrolase
MKRSMSFIITFLLSFIFLILFLIWWNQERLIFFPEKLSENFIFHFPNEFKEIKLTTPDGEKSYGLFFPSKNNLSKKTILFFHGNAGSLRTWGRIYEDFLPIGWNLLITDYRGYGKNSGSISEESMNSDAELWLSYLLNEIKIPRNEIVIYGRSIGTGVAIDLVSKNPDLNLFLETPFIDLFTLARNYYPFIQAWMLKFQFQNLAKLKNIRSKIRIFHGTQDPIIPYSNSEIIFKKLKEQNQDVILFTISNGSHNDLTIYPEYHRALKNSLDEL
>NZ_CP011410.1|WP_000121286.1|4263141_4264005_-|S-methyl-5'-thioadenosine-phosphorylase
MSYNVRVAIIGGTGLYSLEGMELIEEIFPDTPWGKPSDKIKIGKYKGKLIAFLPRHGIGHFLSPPEVPNHANICALKQLGVEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTRFRNSTYFGNGVVAHAPFAEPFSPNLSKRIAQTAKKIGLEIHLDKTLVCMEGPLFSTKAESHLYRSWGADIINMTVLPEAKLAREAEIAYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKLLSELIHVLGNGDDLSLKNSTRYSIITAPEKRNPETVKKLRVLFPEYF
>NZ_CP011410.1|WP_000043664.1|4264723_4266292_-|chemotaxis-protein
MSKQSIESIRKKGEALTYYSRMTIMVMVLISLAASFKTLQIQIKIIHSSAAFFMFVYTLFGFILYKKYEIKQWVHNLFIIFDSLILSVTIFLDSMVSPELISPVLKNAILYSVYYFIIAYSGLLGRPKFVLITGMFCYFGYSIALTNAAFHGLRFSEDNTINMKPGYVKLSAEITKIFFMAGVSLILYRLMNLFDELYQEASSYFQENKDFLNKLENNRKIIHSSAETLELSVTNFSEFTSLTSEKMESQAASLEEVNAVITSLSKSSEKNADSIRIQNENLIELNQKAQTLLEVIAEISDHSKGLDVNAKESKTEMKVVKESVEKTGEFLKNISNSFQRVDEINRILGEIADKTNLLSLNASIEAARAGSAGRGFAVVAQEVSKLAEFTATNAKMIAKVVQESLEFIEEANTASQGTGHLTENQSIKVNLTVSKIEEMSRLYERGTTIVNDFVKNLERVKKLSDNLFHSTEEQMTAQKEMMKAMFELEKEVNEITQESGRIQDGVLQIKTQSRDLKALSIV
>NZ_CP011410.1|WP_000350173.1|4266867_4267698_-|methylated-DNA--[protein]-cysteine-S-methyltransferase
MDHYKKISEAIQFIQKNAISQPELDEVAKSVNLSPFHFQRLFTEWAGVSPKQFLQYITLQNAKSILSKPQTTLFDAAFETGLSGTSRLHDLFVKIEGMTPGEFKNGGENIKIRYSFQKSIFGDYLIASTEKGICNLFFYDIPKEQIVSELKEQWERADIIEQMDENQNRVIRFFDKTLNGHEKIKLHLKGTEFQIKVWEALLKIPEGQLSSYSDIADLIGQENASRAVGTAIGKNPIGYLIPCHRVIKSTGGIGEYRWGSERKMAMIGWEASKVKI
>NZ_CP011410.1|WP_000580059.1|4267892_4268666_-|cobalamin-binding-protein
MIGPKRIICLTEETTELFYLLGIEERIVGISAYTVRPLRAKKEKPKISAFINGNIKRIKELKPDLVIGFSDIQSDLAKNLIAEGLNVLVTNQRTILEIFDTLSLLGSIVGKGNETQKLIEGWKRKLDEIERVYSSKSQPSVFFQEWDEPIITGISWVSELIKLAGGKDCFEHLKTKSLAKDRIISAIDVAKANPEVYIGSWCGKPMNFEWVQKHPDWQNVNAILNHKVYELDPSIILQPGPALFEEGIDQLVKLIHS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP011410_8	8.1\|1677164\|48\|NZ_CP011410\|CRISPRCasFinder	1677164-1677211	48	NZ_CP011410.1	1291047-1291094	0	1.0
NZ_CP011410_11	11.1\|4252958\|47\|NZ_CP011410\|CRISPRCasFinder	4252958-4253004	47	NZ_CP011410.1	972663-972709	0	1.0
NZ_CP011410_11	11.1\|4252958\|47\|NZ_CP011410\|CRISPRCasFinder	4252958-4253004	47	NZ_CP011410.1	1291047-1291093	0	1.0
NZ_CP011410_10	10.1\|4086828\|46\|NZ_CP011410\|CRISPRCasFinder	4086828-4086873	46	NZ_CP011410.1	972664-972709	1	0.978
NZ_CP011410_10	10.1\|4086828\|46\|NZ_CP011410\|CRISPRCasFinder	4086828-4086873	46	NZ_CP011410.1	1291047-1291092	1	0.978
NZ_CP011410_11	11.1\|4252958\|47\|NZ_CP011410\|CRISPRCasFinder	4252958-4253004	47	NZ_CP011410.1	3476881-3476927	1	0.979
NZ_CP011410_10	10.1\|4086828\|46\|NZ_CP011410\|CRISPRCasFinder	4086828-4086873	46	NZ_CP011410.1	3476882-3476927	2	0.957

1. spacer 8.1|1677164|48|NZ_CP011410|CRISPRCasFinder matches to position: 1291047-1291094, mismatch: 0, identity: 1.0

ccaacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
ccaacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
************************************************

2. spacer 11.1|4252958|47|NZ_CP011410|CRISPRCasFinder matches to position: 972663-972709, mismatch: 0, identity: 1.0

caaactcaatgcatcgctccctaagggtcgctctgcaggtcgcgttg	CRISPR spacer
caaactcaatgcatcgctccctaagggtcgctctgcaggtcgcgttg	Protospacer
***********************************************

3. spacer 11.1|4252958|47|NZ_CP011410|CRISPRCasFinder matches to position: 1291047-1291093, mismatch: 0, identity: 1.0

caaactcaatgcatcgctccctaagggtcgctctgcaggtcgcgttg	CRISPR spacer
caaactcaatgcatcgctccctaagggtcgctctgcaggtcgcgttg	Protospacer
***********************************************

4. spacer 10.1|4086828|46|NZ_CP011410|CRISPRCasFinder matches to position: 972664-972709, mismatch: 1, identity: 0.978

aacgcgacctggagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
*********** **********************************

5. spacer 10.1|4086828|46|NZ_CP011410|CRISPRCasFinder matches to position: 1291047-1291092, mismatch: 1, identity: 0.978

aacgcgacctggagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
*********** **********************************

6. spacer 11.1|4252958|47|NZ_CP011410|CRISPRCasFinder matches to position: 3476881-3476927, mismatch: 1, identity: 0.979

caaactcaatgcatcgctccctaagggtcgctctgcaggtcgcgttg	CRISPR spacer
caaactcaatgcatcgctccctaaggatcgctctgcaggtcgcgttg	Protospacer
**************************.********************

7. spacer 10.1|4086828|46|NZ_CP011410|CRISPRCasFinder matches to position: 3476882-3476927, mismatch: 2, identity: 0.957

aacgcgacctggagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgatccttagggagcgatgcattgagtttg	Protospacer
*********** *******.**************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP011410_4	4.3\|1272802\|34\|NZ_CP011410\|CRISPRCasFinder,CRT,PILER-CR	1272802-1272835	34	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	2877-2910	5	0.853

1. spacer 4.3|1272802|34|NZ_CP011410|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 5, identity: 0.853

aaattgcatataagactacagatatggttgttaa	CRISPR spacer
atacaaaatataagactacagatatggttgttaa	Protospacer
* *. . ***************************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

865687 : 879648

Leptospira_phage(100.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000835571.1\|865687_866311_-	tetratricopeptide repeat protein	S5VKQ0	Leptospira_phage	5.3e-50	57.0
WP_001032070.1\|866319_868059_-	hypothetical protein	S5VKK9	Leptospira_phage	1.4e-228	80.1
WP_000162786.1\|868055_868940_-	hypothetical protein	S5VSU6	Leptospira_phage	5.4e-133	81.0
WP_047020753.1\|869220_876240_+	membrane protein	S5W9E6	Leptospira_phage	0.0e+00	74.1
WP_001031919.1\|876232_876703_+	hypothetical protein	NA	NA	NA	NA
WP_002186814.1\|876932_877169_+	hypothetical protein	S5W9C6	Leptospira_phage	1.3e-20	69.3
WP_000837513.1\|877171_878389_+	kelch-like protein	NA	NA	NA	NA
WP_000692272.1\|878796_879648_+	hypothetical protein	S5W9A4	Leptospira_phage	1.9e-103	67.4

DBSCAN-SWA_2

914648 : 921681

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000078859.1\|914648_915473_+	ParA family protein	S5VST6	Leptospira_phage	2.6e-60	46.4
WP_000253888.1\|915500_916412_+	ParB/RepB/Spo0J family partition protein	S5VSZ7	Leptospira_phage	1.0e-49	42.7
WP_000141297.1\|916805_918245_+	hypothetical protein	S5W9F7	Leptospira_phage	4.3e-196	75.3
WP_047020757.1\|918427_919051_-	tetratricopeptide repeat protein	S5VKQ0	Leptospira_phage	3.1e-50	56.9
WP_047020758.1\|919060_920800_-	galactose oxidase	S5VKK9	Leptospira_phage	1.2e-227	79.7
WP_000162763.1\|920796_921681_-	hypothetical protein	S5VSU6	Leptospira_phage	1.6e-132	80.3

DBSCAN-SWA_3

2664555 : 2672758

Enterobacteria_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000842258.1\|2664555_2665440_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	3.7e-97	60.3
WP_000723090.1\|2665440_2666490_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	4.5e-94	51.2
WP_000642160.1\|2666486_2667407_-	dTDP-4-dehydrorhamnose reductase	NA	NA	NA	NA
WP_001159752.1\|2667410_2667971_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	2.7e-45	52.9
WP_000853994.1\|2668166_2669915_-	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	7.7e-06	33.3
WP_000282884.1\|2670629_2671451_-	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	4.1e-10	30.0
WP_000560749.1\|2671960_2672758_-	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	2.7e-06	35.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP011410

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection