CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NZ_CP011405	Lactobacillus salivarius str. Ren plasmid pR2, complete sequence	1 crisprs	NA	0	1	0
NZ_CP011403	Lactobacillus salivarius str. Ren chromosome, complete genome	2 crisprs	cas1,cas2,csn2,DEDDh,DinG,csa3,cas3,cas6,cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7,csm6,WYL	3	10	9
NZ_CP011404	Lactobacillus salivarius str. Ren plasmid pR1, complete sequence	0 crisprs	cas14j,c2c4_V-U1	0	0	2

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP011405_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011405_1

598-755

Orphan

Consensus_repeat	Method
AAACCCTTGATACAAGCGGAACTGCAAAAAATGCAGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011405_1

>merge|NZ_CP011405|1|598-755|CRISPRCasFinder
AAACCCTTGATACAAGCGGAACTGCAAAAAATGCAGTTCCGCAAGAGACCGTTGAAACCCTTGATACAAGCGGAACTGCAAAAAATGCAGTTCCGCAAGAGACCGTTGAAAAAAGCCCTCAAACCCTTGATACAAGCGGAACTGCAAAAATGCAGTTA

>NZ_CP011405|1|1|598-755|CRISPRCasFinder
AAACCCTTGATACAAGCGGAACTGCAAAAAATGCAGTT	CCGCAAGAGACCGTTGAAACCCTTGATACAAGCGGAACTGCAAAAAATGCAGTTCCGCAAGAGACCGTTGAAAAAAGCCCTC
AAACCCTTGATACAAGCGGAACTGCAAAAATGCAGTTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011405.1\|WP_080951865.1\|3930_4137_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011405.1\|WP_047036250.1\|10475_11342_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP011405.1\|WP_047036285.1\|2751_3033_+\|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	unknown	unknown	gnl\|CDD\|274102
NZ_CP011405.1\|WP_047036246.1\|7953_8976_+\|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|176214
NZ_CP011405.1\|WP_023466429.1\|12209_12662_+\|LytTR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197918
NZ_CP011405.1\|WP_047036241.1\|1454_1601_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011405.1\|WP_021353390.1\|7089_7179_-\|putative-holin-like-toxin	unknown	unknown	unknown
NZ_CP011405.1\|WP_047036248.1\|8979_9660_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011405.1\|WP_047036245.1\|7437_7785_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP011405.1\|WP_007122532.1\|11343_12204_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912

Protein	Function_ID	Function_description	E-value
NZ_CP011405.1\|WP_047036285.1\|2751_3033_+\|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	gnl\|CDD\|274102	TIGR02384, Putative_antitoxin_RelB, addiction module antitoxin, RelB/DinJ family. Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other].	2.24723e-12
NZ_CP011405.1\|WP_047036250.1\|10475_11342_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.67714e-80
NZ_CP011405.1\|WP_047036245.1\|7437_7785_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.12314e-37
NZ_CP011405.1\|WP_047036246.1\|7953_8976_+\|zinc-binding-alcohol-dehydrogenase-family-protein	gnl\|CDD\|176214	cd08252, AL_MDR, Arginate lyase and other MDR family members. This group contains a structure identified as an arginate lyase. Other members are identified quinone reductases, alginate lyases, and other proteins related to the zinc-dependent dehydrogenases/reductases. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
NZ_CP011405.1\|WP_023466429.1\|12209_12662_+\|LytTR-family-transcriptional-regulator	gnl\|CDD\|197918	smart00850, LytTR, LytTr DNA-binding domain. This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.	2.14151e-16
NZ_CP011405.1\|WP_007122532.1\|11343_12204_+\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	3.29288e-05

>NZ_CP011405.1|WP_047036241.1|1454_1601_+|hypothetical-protein
MKKIEQLLADPWAVDIQDIWEQAAQNRDPDKCKLFDALHTYLLDKRQE
>NZ_CP011405.1|WP_047036285.1|2751_3033_+|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin
MAVKEKKRVQVKIDKDLADNTEAVLNELGLNPTTAINMFYKRIVAEAALPFKPALSEAERANLRFLKATEGTPVTELKDAKGVSDWLNDPDED
>NZ_CP011405.1|WP_080951865.1|3930_4137_-|hypothetical-protein
MSNQYEKLVEQQARKARSRRLIQKGALLEKYFQADNLSVEQTEELLKIFANYVNAHKPNKFKNDQPNN
>NZ_CP011405.1|WP_021353390.1|7089_7179_-|putative-holin-like-toxin
MSVFQTLSLMLLFGTFLIALLSYIDKHHK
>NZ_CP011405.1|WP_047036245.1|7437_7785_-|helix-turn-helix-transcriptional-regulator
MQRHIFNCSNGCPVESTLQIISGKWKSVILYHLIKNRVCRFSELQKKMPNCSRRMLSLQLNELEKDKIIEKKIYPVIPPKTEYRMTRFGETLTPIILEMDKWGQTYNSINSEDSN
>NZ_CP011405.1|WP_047036246.1|7953_8976_+|zinc-binding-alcohol-dehydrogenase-family-protein
MKAIGFTQHLNINDSRSLFEFEESIPVPKGHDLLVKVNAVSVNPVDVGVRRGGHGKLKTPKVIGWDACGIVKKVGNQVSLFNPGDRVYYAGSFKRPGSNSEYQLVDERIVGHAPKSLSDDEAAAMPLTSLTAYEALFEQLSLSSNSQSNKDKTILIINGAGGVGSVATQLAVNAGLTVIATASRPESINWVKSHGAKYTVNHRNNLVDEVRELGYKFVDYILELKDIDNHWKEMCELIKPEGAIASITENKRPINLRLLTQKKAIFAWEWMYTKSYYHTNDMQTQHDILEKIAYFLDNGQLKCTLTHSLSPLNATNLRKAHSLVESGHMVGKVVVSGWEE
>NZ_CP011405.1|WP_047036248.1|8979_9660_+|hypothetical-protein
MIENDRYYRRYVKDVKSGYIFLQTGLVKKAILDSIFEINYRLTIQITKDKKFTDQTFFKDTPYTPVFDKTPSKYSKRLIKQIHHLQNLYKDNNISDLVNNISAFLKEIDGITDVQKLTHDYLNLLKEINYVMPFLSSNKTGYANLINKYDRLLLLVDLKTSQQNNSTLNYPELDNAKLLSSPYITNEEFEYLVANLTKYLGLVSKLKNRSLFCFAGQIGKCQNHVQ
>NZ_CP011405.1|WP_047036250.1|10475_11342_+|ABC-transporter-ATP-binding-protein
MKLTTTDLTKRYGQKAVVKNLNLEIPAQSLVAFLGNNGAGKSTTISMLIGLLKPTAGQINFLDEHNQPCQPKIGVVFQNSILDNELTVKENLYFRAMMQGKQSVANIGKVTEVLGLSNFLEQKYGSLSGGQKRRVDIARALLNDPDFLFLDEPTTGLDIQTRTVIWQLLNDLRQKNNLTIFLTTHYLEEAHDANLVYIVNQGAVIACGSAAEIIAANTENYLEIRTSHKFAFPANCEKVGQDQYRIIDLPISAAIDFLAQNRAVIEQFEYHHGTLDDAFMNLTGKELQ
>NZ_CP011405.1|WP_007122532.1|11343_12204_+|ABC-transporter-permease
MLPLIRRNLKLFFRNRAGVFFSLLGALISFGLFIIFLKSNMLDSWKQLQHPARVLDLWVIGGTLAVASITTTLSALSRMVSDLEYRVFDDLILTGLSRLKIRLSYVLAATIIGTLLQIALFLIMVSYFSWVDGISIPGYITFQVLIVTILASFSASVLNFILVYRMKNIDTVGKFSSIVGAASGFLVGIYIPIGVLPTFAQNLVKLTPGAYVAAIYRQLLMHDILKNVQPNILHNLQKTLGIGINLNGNLTTKLQNFAIVTGVTVILLIIILITNKHDQNKSVSTE
>NZ_CP011405.1|WP_023466429.1|12209_12662_+|LytTR-family-transcriptional-regulator
MEVRFEKNIITGEEIEVIVKANRLTNNVKSLMAYINQFDQKPHRILPIKTNDSIIIVKVDDIILVDVQKNTLSIETLTAKYLIQERLYKFIQKLPKDIFVQVSKHAVINLDYLLSLEDSFAGSMTAKMEKSLRTSVSRKYLSDLEEHLGL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP011405_1	1.1\|636\|82\|NZ_CP011405\|CRISPRCasFinder	636-717	82	NZ_CP011405	Lactobacillus salivarius str. Ren plasmid pR2, complete sequence	636-717	22	0.732
NZ_CP011405_1	1.1\|636\|82\|NZ_CP011405\|CRISPRCasFinder	636-717	82	CP031020	Lactobacillus helveticus isolate NWC_2_4 plasmid pNWC_2_4, complete sequence	19115-19196	23	0.72
NZ_CP011405_1	1.1\|636\|82\|NZ_CP011405\|CRISPRCasFinder	636-717	82	CP031020	Lactobacillus helveticus isolate NWC_2_4 plasmid pNWC_2_4, complete sequence	19061-19142	23	0.72
NZ_CP011405_1	1.1\|636\|82\|NZ_CP011405\|CRISPRCasFinder	636-717	82	NZ_CP019582	Lactobacillus helveticus strain LH5 plasmid pCBTLH5_1, complete sequence	3436-3517	24	0.707
NZ_CP011405_1	1.1\|636\|82\|NZ_CP011405\|CRISPRCasFinder	636-717	82	NZ_CP035308	Lactobacillus helveticus strain IDCC3801 plasmid pHel23910, complete sequence	13784-13865	24	0.707
NZ_CP011405_1	1.1\|636\|82\|NZ_CP011405\|CRISPRCasFinder	636-717	82	NZ_CP011405	Lactobacillus salivarius str. Ren plasmid pR2, complete sequence	582-663	31	0.622
NZ_CP011405_1	1.1\|636\|82\|NZ_CP011405\|CRISPRCasFinder	636-717	82	CP031020	Lactobacillus helveticus isolate NWC_2_4 plasmid pNWC_2_4, complete sequence	19007-19088	31	0.622
NZ_CP011405_1	1.1\|636\|82\|NZ_CP011405\|CRISPRCasFinder	636-717	82	NZ_CP019582	Lactobacillus helveticus strain LH5 plasmid pCBTLH5_1, complete sequence	3490-3571	31	0.622
NZ_CP011405_1	1.1\|636\|82\|NZ_CP011405\|CRISPRCasFinder	636-717	82	NZ_CP035308	Lactobacillus helveticus strain IDCC3801 plasmid pHel23910, complete sequence	13838-13919	31	0.622

1. spacer 1.1|636|82|NZ_CP011405|CRISPRCasFinder matches to NZ_CP011405 (Lactobacillus salivarius str. Ren plasmid pR2, complete sequence) position: , mismatch: 22, identity: 0.732

ccgcaagagaccgttgaaacccttgatacaagcggaactgcaaaaaatgcagttccgcaa	CRISPR spacer
ccgcaagagaccgttgaaacccttgatacaagcggaactgcaaaaaatgcagttccgcaa	Protospacer
************************************************************

2. spacer 1.1|636|82|NZ_CP011405|CRISPRCasFinder matches to CP031020 (Lactobacillus helveticus isolate NWC_2_4 plasmid pNWC_2_4, complete sequence) position: , mismatch: 23, identity: 0.72

ccgcaagagaccgttgaaacccttgatacaagcggaactgcaaaaaatgcagttccgcaa	CRISPR spacer
ccgcaagagaccgttgaaacccttgctacaagcggaactgcaaaaaatgcagttccgcaa	Protospacer
************************* **********************************

3. spacer 1.1|636|82|NZ_CP011405|CRISPRCasFinder matches to CP031020 (Lactobacillus helveticus isolate NWC_2_4 plasmid pNWC_2_4, complete sequence) position: , mismatch: 23, identity: 0.72

ccgcaagagaccgttgaaacccttgatacaagcggaactgcaaaaaatgcagttccgcaa	CRISPR spacer
ccgcaagagaccgttgaaacccttgctacaagcggaactgcaaaaaatgcagttccgcaa	Protospacer
************************* **********************************

4. spacer 1.1|636|82|NZ_CP011405|CRISPRCasFinder matches to NZ_CP019582 (Lactobacillus helveticus strain LH5 plasmid pCBTLH5_1, complete sequence) position: , mismatch: 24, identity: 0.707

ccgcaagagaccgttgaaacccttgatacaagcggaactgcaaaaaatgcagttccgcaa	CRISPR spacer
ccgcaagagaccgttgaaatccttgctacaagcggaactgcaaaaaatgcagttccgcaa	Protospacer
*******************.***** **********************************

5. spacer 1.1|636|82|NZ_CP011405|CRISPRCasFinder matches to NZ_CP035308 (Lactobacillus helveticus strain IDCC3801 plasmid pHel23910, complete sequence) position: , mismatch: 24, identity: 0.707

ccgcaagagaccgttgaaacccttgatacaagcggaactgcaaaaaatgcagttccgcaa	CRISPR spacer
ccgcaagagaccgttgaaatccttgctacaagcggaactgcaaaaaatgcagttccgcaa	Protospacer
*******************.***** **********************************

6. spacer 1.1|636|82|NZ_CP011405|CRISPRCasFinder matches to NZ_CP011405 (Lactobacillus salivarius str. Ren plasmid pR2, complete sequence) position: , mismatch: 31, identity: 0.622

ccgcaagagaccgttgaaacccttgatacaagcggaactgcaaaaaatgcagttccgcaa	CRISPR spacer
gggcaaaaagagcctgaaacccttgatacaagcggaactgcaaaaaatgcagttccgcaa	Protospacer
  ****.*..   .**********************************************

7. spacer 1.1|636|82|NZ_CP011405|CRISPRCasFinder matches to CP031020 (Lactobacillus helveticus isolate NWC_2_4 plasmid pNWC_2_4, complete sequence) position: , mismatch: 31, identity: 0.622

ccgcaagagaccgttgaaacccttgatacaagcggaactgcaaaaaatgcagttccgcaa	CRISPR spacer
gggcaaaaaaagcctgaaacccttgctacaagcggaactgcaaaaaatgcagttccgcaa	Protospacer
  ****.*.*   .*********** **********************************

8. spacer 1.1|636|82|NZ_CP011405|CRISPRCasFinder matches to NZ_CP019582 (Lactobacillus helveticus strain LH5 plasmid pCBTLH5_1, complete sequence) position: , mismatch: 31, identity: 0.622

ccgcaagagaccgttgaaacccttgatacaagcggaactgcaaaaaatgcagttccgcaa	CRISPR spacer
gggcaaaaaaagcctgaaacccttgctacaagcggaactgcaaaaaatgcagttccgcaa	Protospacer
  ****.*.*   .*********** **********************************

9. spacer 1.1|636|82|NZ_CP011405|CRISPRCasFinder matches to NZ_CP035308 (Lactobacillus helveticus strain IDCC3801 plasmid pHel23910, complete sequence) position: , mismatch: 31, identity: 0.622

ccgcaagagaccgttgaaacccttgatacaagcggaactgcaaaaaatgcagttccgcaa	CRISPR spacer
gggcaaaaaaagcctgaaacccttgctacaagcggaactgcaaaaaatgcagttccgcaa	Protospacer
  ****.*.*   .*********** **********************************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP011403_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011403_1

124138-124948

TypeII-A

Consensus_repeat	Method
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	PILER-CR
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	CRISPRCasFinder
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	CRT

11 spacers

csn2,cas2,cas1

The CRISPR arrays of NZ_CP011403_1

>merge|NZ_CP011403|1|124138-124948|PILER-CR,CRISPRCasFinder,CRT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACCTAGAAGAAGTGAAAAACAATCTTACTAATTGTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACCTGACGAAGCTCCTAATGACTACAAAGTTTTGTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACCTTCAGGGACAGTATACGGACAAGGGTATCAGTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACCAGCCCCAGGTTCCTAATAATCCAACAACACGTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACCTTCAGGGACAGTATACGGACAAGGGTATCAGTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACCAGCAACTTTGACTAAACAAGTTATGCAATTGTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACCTGACGAAGCTCCTAATGACTACAAAGTTTTGTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACCTTCAGGGACAGTATACGGACAAGGGTATCAGTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACCAGCAACTTTGACTAAACAAGTTATGCAATTGTTTCAGAAGTATGTTAAATCAATTAGGTTAAGAACGGTTCTGAGCCTAGTTAGAATGAATAGGTGTTTCAGAAGAATATTAAATTAATTAGATTAATATCTTGACTTTGTCTCCACAGTTATATATTCTAATTTCAGAATATATTAATTGACTATTTTAGAGTGGTTAGTTTAGGTATTAGTTTCAGAAGAATGTTAAATTAATAGGGTCGAGGCC

>NZ_CP011403|1|1|124138-124767|PILER-CR
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TAGAAGAAGTGAAAAACAATCTTACTAATT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TGACGAAGCTCCTAATGACTACAAAGTTTT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TTCAGGGACAGTATACGGACAAGGGTATCA
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	AGCCCCAGGTTCCTAATAATCCAACAACAC
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TTCAGGGACAGTATACGGACAAGGGTATCA
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	AGCAACTTTGACTAAACAAGTTATGCAATT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TGACGAAGCTCCTAATGACTACAAAGTTTT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TTCAGGGACAGTATACGGACAAGGGTATCA
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	AGCAACTTTGACTAAACAAGTTATGCAATT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGAAC

>NZ_CP011403|1|1|124138-124948|CRISPRCasFinder
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TAGAAGAAGTGAAAAACAATCTTACTAATT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TGACGAAGCTCCTAATGACTACAAAGTTTT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TTCAGGGACAGTATACGGACAAGGGTATCA
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	AGCCCCAGGTTCCTAATAATCCAACAACAC
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TTCAGGGACAGTATACGGACAAGGGTATCA
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	AGCAACTTTGACTAAACAAGTTATGCAATT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TGACGAAGCTCCTAATGACTACAAAGTTTT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TTCAGGGACAGTATACGGACAAGGGTATCA
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	AGCAACTTTGACTAAACAAGTTATGCAATT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGAAC	GGTTCTGAGCCTAGTTAGAATGAATAGGT
GTTTCAGAAGAATATTAAATTAATTAGATTAATATC	TTGACTTTGTCTCCACAGTTATATATTCTAATTTCAGAATATATTAATTGACTATTTTAGAGTGGTTAGTTTAGGTATTA
GTTTCAGAAGAATGTTAAATTAATAGGGTCGAGGCC

>NZ_CP011403|1|1|124138-124832|CRT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TAGAAGAAGTGAAAAACAATCTTACTAATT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TGACGAAGCTCCTAATGACTACAAAGTTTT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TTCAGGGACAGTATACGGACAAGGGTATCA
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	AGCCCCAGGTTCCTAATAATCCAACAACAC
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TTCAGGGACAGTATACGGACAAGGGTATCA
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	AGCAACTTTGACTAAACAAGTTATGCAATT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TGACGAAGCTCCTAATGACTACAAAGTTTT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	TTCAGGGACAGTATACGGACAAGGGTATCA
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGACC	AGCAACTTTGACTAAACAAGTTATGCAATT
GTTTCAGAAGTATGTTAAATCAATTAGGTTAAGAAC	GGTTCTGAGCCTAGTTAGAATGAATAGGT
GTTTCAGAAGAATATTAAATTAATTAGATTAATATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011403.1\|WP_047034973.1\|115484_116669_+\|3-phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|240651
NZ_CP011403.1\|WP_003704561.1\|127033_127264_+\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|377200
NZ_CP011403.1\|WP_047034975.1\|116670_117267_+\|uracil-DNA-glycosylase-family-protein	unknown	unknown	gnl\|CDD\|381683
NZ_CP011403.1\|WP_047034986.1\|133639_134440_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224097
NZ_CP011403.1\|WP_080951796.1\|117861_118026_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|377949
NZ_CP011403.1\|WP_003700771.1\|128315_129830_+\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|234594
NZ_CP011403.1\|WP_011475517.1\|117362_117860_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011403.1\|WP_047034980.1\|125441_126047_+\|DUF1700-domain-containing-protein	unknown	unknown	gnl\|CDD\|227053
NZ_CP011403.1\|WP_041822588.1\|125117_125426_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP011403.1\|WP_047034978.1\|123434_124106_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
NZ_CP011403.1\|WP_003709117.1\|123132_123438_+\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
NZ_CP011403.1\|WP_047034971.1\|112414_113965_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366353
NZ_CP011403.1\|WP_047034985.1\|132533_133622_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_CP011403.1\|WP_047034984.1\|131707_132415_+\|aquaporin-family-protein	unknown	unknown	gnl\|CDD\|223653
NZ_CP011403.1\|WP_011475529.1\|129842_131672_+\|type-1-glycerol-3-phosphate-oxidase	unknown	unknown	gnl\|CDD\|380303
NZ_CP011403.1\|WP_047034983.1\|127602_127914_+\|bacteriocin-immunity-protein	unknown	unknown	gnl\|CDD\|370205
NZ_CP011403.1\|WP_011475526.1\|126049_127015_+\|DUF4097-domain-containing-protein	unknown	unknown	gnl\|CDD\|372574
NZ_CP011403.1\|WP_047034977.1\|122249_123155_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NZ_CP011403.1\|WP_047034972.1\|114385_115477_+\|3-phosphoserine/phosphohydroxythreonine-transaminase	unknown	unknown	gnl\|CDD\|235428
NZ_CP011403.1\|WP_047034969.1\|111904_112294_+\|DUF956-family-protein	unknown	unknown	gnl\|CDD\|368754

Protein	Function_ID	Function_description	E-value
NZ_CP011403.1\|WP_047034973.1\|115484_116669_+\|3-phosphoglycerate-dehydrogenase	gnl\|CDD\|240651	cd12174, PGDH_like_3, Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains. Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily, which also include groups such as L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. Many, not all, members of this family are dimeric.	1.15455e-150
NZ_CP011403.1\|WP_003704561.1\|127033_127264_+\|PspC-domain-containing-protein	gnl\|CDD\|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	3.63387e-18
NZ_CP011403.1\|WP_047034975.1\|116670_117267_+\|uracil-DNA-glycosylase-family-protein	gnl\|CDD\|381683	cd10033, UDG_like, uncharacterized family of the uracil-DNA glycosylase superfamily. Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Uracil may arise from mis-incorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations; thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other. UDG family 1 is the most efficient uracil-DNA glycosylase (UDG, also known as UNG) and shows a specificity for uracil in DNA. UDG family 2 includes thymine DNA glycosylase which removes uracil and thymine from G:U and G:T mismatches, and mismatch-specific uracil DNA glycosylase (MUG) which in Escherichia coli is highly specific to G:U mismatches but also repairs G:T mismatches at high enzyme concentration. UDG family 3 includes Human SMUG1 which can remove uracil and its oxidized pyrimidine derivatives from, single-stranded DNA and double-stranded DNA with a preference for single-stranded DNA. Pedobacter heparinus SMUG2, which is UDG family 3 SMUG1-like, displays catalytic activities towards DNA containing uracil or hypoxanthine/xanthine. UDG family 4 includes Thermotoga maritima TTUDGA, a robust UDG which like family 1, acts on double-stranded and single-stranded uracil-containing DNA. UDG family 5 (UDGb) includes Thermus thermophilus HB8 TTUDGB which acts on double-stranded uracil-containing DNA; it is a hypoxanthine DNA glycosylase acting on double-stranded hypoxanthine-containing DNA except for the C/I base pair, as well as a xanthine DNA glycosylase which acts on both double-stranded and single-stranded xanthine-containing DNA. UDG family 6 hypoxanthine-DNA glycosylase lacks any detectable UDG activity; it excises hypoxanthine. Other UDG families include one represented by Bradyrhizobium diazoefficiens Blr0248 which prefers single-stranded DNA and removes uracil, 5-hydroxymethyl-uracil or xanthine from it.	5.61807e-99
NZ_CP011403.1\|WP_047034986.1\|133639_134440_+\|ABC-transporter-permease	gnl\|CDD\|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	6.73502e-84
NZ_CP011403.1\|WP_080951796.1\|117861_118026_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|377949	pfam07963, N_methyl, Prokaryotic N-terminal methylation motif. This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.	0.00632994
NZ_CP011403.1\|WP_003700771.1\|128315_129830_+\|glycerol-kinase-GlpK	gnl\|CDD\|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NZ_CP011403.1\|WP_047034980.1\|125441_126047_+\|DUF1700-domain-containing-protein	gnl\|CDD\|227053	COG4709, COG4709, Predicted membrane protein [Function unknown].	6.23387e-12
NZ_CP011403.1\|WP_041822588.1\|125117_125426_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.79274e-16
NZ_CP011403.1\|WP_047034978.1\|123434_124106_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	7.18624e-87
NZ_CP011403.1\|WP_003709117.1\|123132_123438_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	3.80462e-27
NZ_CP011403.1\|WP_047034971.1\|112414_113965_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	3.49603e-36
NZ_CP011403.1\|WP_047034985.1\|132533_133622_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	2.62869e-163
NZ_CP011403.1\|WP_047034984.1\|131707_132415_+\|aquaporin-family-protein	gnl\|CDD\|223653	COG0580, GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism].	1.7726e-62
NZ_CP011403.1\|WP_011475529.1\|129842_131672_+\|type-1-glycerol-3-phosphate-oxidase	gnl\|CDD\|380303	NF033461, glycerol3P_ox_1, type 1 glycerol-3-phosphate oxidase. Glycerol-3-phosphate oxidase, also called alpha-glycerophosphate oxidase (GlpO), is an FAD-dependent enzyme related to the glycerol-3-phosphate dehydrogenase GlpD. Notably, GlpO releases hydrogen peroxide, which can contribute to virulence.	0
NZ_CP011403.1\|WP_047034983.1\|127602_127914_+\|bacteriocin-immunity-protein	gnl\|CDD\|370205	pfam08951, EntA_Immun, Enterocin A Immunity. Gram-positive lactobacilli produce bacteriocins to kill closely-related competitor species. To protect themselves from the bacteriocidal activity of this molecule they co-express an immunity protein (for discussion of this operon see Bacteriocin_IIc pfam10439). The immunity protein structure is a soluble, cytoplasmic, antiparallel four alpha-helical globular bundle with a fifth, more flexible and more divergent C-terminal helical hair-pin. The C-terminal hair-pin recognizes the C-terminus of the producer bacteriocin and this interaction is sufficient to dis-orient the bacteriocin within the membrane and close up the permeabilising pore that on its own the bacteriocin creates. These immunity proteins interact in the same way with other bacteriocins, family Bacteriocin_II, pfam01721. Since many enterococci can produce more than one bacteriocin it seems likely that the whole operon can be carried on transferable plasmids.	7.45672e-10
NZ_CP011403.1\|WP_011475526.1\|126049_127015_+\|DUF4097-domain-containing-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	1.54446e-43
NZ_CP011403.1\|WP_047034977.1\|122249_123155_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.01197e-120
NZ_CP011403.1\|WP_047034972.1\|114385_115477_+\|3-phosphoserine/phosphohydroxythreonine-transaminase	gnl\|CDD\|235428	PRK05355, PRK05355, 3-phosphoserine/phosphohydroxythreonine transaminase.	0
NZ_CP011403.1\|WP_047034969.1\|111904_112294_+\|DUF956-family-protein	gnl\|CDD\|368754	pfam06115, DUF956, Domain of unknown function (DUF956). Family of bacterial sequences with undetermined function.	4.87348e-62

>NZ_CP011403.1|WP_047034978.1|123434_124106_+|type-II-A-CRISPR-associated-protein-Csn2
MKLYYTGHKNIEINAGKITVLGTNNVDVYKEFIDTFLNGYGNNIQLSDDKYNRKDISTSIDWDGDVMLTDRISKKYMNVLIKKIIEDITDDERQAILKSVNGLYDRIREVLYKIDIPLQVDYDNDLTRLFKYCQVHTEALLWKNAYDRISSDVKLHVELNRERIIGLTNVAHYLTKEEFQELVNLVKVTNASMFIIEFTEKNGQRFFENCDNYYIDEDYIDWY
>NZ_CP011403.1|WP_003709117.1|123132_123438_+|CRISPR-associated-endonuclease-Cas2
MRLMIMFDLPVETSEERKEYRKFRKNLINEGFIMIQYSVYVRVCVNKKSAEFTEKRIESFLPSKGVVQSLILTEKQYNDMHFLLGKKIKEVRNSAERTIIL
>NZ_CP011403.1|WP_047034977.1|122249_123155_+|type-II-CRISPR-associated-endonuclease-Cas1
MGFRNVIITQHSKLSYSNNAMIVQNKDGINQIPLVDMDILLISTTQAVITSALVGKLAESGIKVIFTDNKNEPVTETVNYYPNNRSLGTYLQQYEWNDHVKEILWTKIVRSKIINQIKVLKNYQIDCQDLKNELDKLEINDMTNREAVVARKYFEKLFGNKYSRKDFTPMNAALNYGYSILLSAVNKEIVSAGYVTYLGIHHQSQENMFNFGSDLMEPFRPVVDYWLADKNFLEFTPDIKYGLVDLLNLEIKYNKKQMLLKNAITKYVRDVIEYLNQETVEFDMEVEFTNEVPNNAINDNV
>NZ_CP011403.1|WP_080951796.1|117861_118026_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MPPSEKLHYNYTIVFIKFFKYIINNFRHGFTLIEMTIALFIQSKKACRSYPHTF
>NZ_CP011403.1|WP_011475517.1|117362_117860_+|hypothetical-protein
MLKNLNLTFGPEKQLQEIIENNKDRQMVLLESVTDSEKFALLDISNEESIFHSQLDYRIYHTINLKEWNGFFEFRYVTLDTEQQKIFNAHLGKWDDPFNRPVGLKSTLVGHDERKDYEFLMINIWEDQEDYVEWENESDNEFREFGHGGNAKALVAQYKLVKNKE
>NZ_CP011403.1|WP_047034975.1|116670_117267_+|uracil-DNA-glycosylase-family-protein
MIKTADEFQRIFEEIKLDPQNQEYTEKGIEPLYYANPKAKILIVGQAPGQKAQDTHMVWNDLSGDRLRTWLDVSRDEFYNSDLFAIMPMDFYFPGKGKGGDLPPRKNFAAKWHPKLRKLMPNIELTILVGSYAVKKYLNLKSSAKLTDIVKDYQTYLPEYFPLVHPSPRNLIWLKKNPWFEEQVVKDLQKLVSEIKNK
>NZ_CP011403.1|WP_047034973.1|115484_116669_+|3-phosphoglycerate-dehydrogenase
MKDIKTYNVIAQEGLDELPADMYTVNKSTKPDALLIRSQDMHKTPFGTSVLAIARAGAGVNNIPLEKATSQGTAVFNTPGSNANAVKELIITMLLLSVRPVFASVKWAQKLAGADVSLQTEKGKNHFAGTELYGKKIGIIGLGNIGSRVAKACMDLGMKVIGYDPYISVEKAWQLSNDIPRAESLEELLEQSDFITIHIPYTDKNRNIIGEDEINVMKDTAVLLNYSRWGIVDEDAVIKALDAKKLRLFITDFSSEKILNHKQIIVTPHLGGTTEEAEVNGAKMAANTLRKYLETGDIVNSVNLPNVEMAFDAPLRLTLIHQNVPNMVGRITTTLAKEEINIDNMINRSRGKIAYTMIDAADISEGKLKELKKELLEISEVIRVRALHNPKFVK
>NZ_CP011403.1|WP_047034972.1|114385_115477_+|3-phosphoserine/phosphohydroxythreonine-transaminase
MTKVYNFSAGPAVLPKEVIKKAQDELTSFKGSQMSVMEISHRSSLYTEMFQKAEEDLRYLMEIPDDYDILFQQGGATLQFTAVPLNLANNYRRIGYIDTGHWSQRAYQEAELLHKFDVDVVASSKDSNYTELVHQVELENKKYDYVHLTTNNTIEGTMYRDLPLGLAGQTIVADMSSNILGQKYNVDDFGLIYAGAQKNIGIAGLTVVIVKRDLIGKVSNLPSMLDYKKQADKQSALNTPPVFAIYMAGLVFEWLKEQGGVAAMQALNEEKSQLLYEYLDNSTLFSSPVKREDRSLTNIPFVTGNKKLDEKFIAEATSAGLLNLKGHRLVGGMRASLYNAFELEGVKVLVDFMKEFELKNKGE
>NZ_CP011403.1|WP_047034971.1|112414_113965_-|LysM-peptidoglycan-binding-domain-containing-protein
MKKTAQKLLVGTVGAAGVLLASSTAANADSTTTHKVKQNETVWALSKKYGVSIQSIEKLNRINSNHLIITGQTLQIPSKDGSQTVNKNDNKSTYTIKSGDTLWRIAQNNHISLDELLSLNNLNASDIIYPGQVIKLTSAAATSTPSTQQQVQDKATVTTPATDNQSSQAQATSASSSSQAVSTAQNSSAATTATSSSVTTPAASQAAATSSSSSVAQQPAASSSSAVQQSSSQVTTQSSSEVKDDNAQKVQYTAKAGDSLYSIAQSFGVSIDSLRSNNNLGATLLPGQTLTIVNPTKTPSQEESSSNSVATNNTATTSSAAQSSSQQSVANNSVAQTSSSQQQTVTTPAASSSSAASSSSVAQTNNTQQATTTNTAATNNNATTVNTSNVTTTTNTGSASASAIISYAQSFIGVPYVWGGSTPSGFDCSGLVQYVYAHYGVNLPRVTTAQENAGTVIPVSAAQPGDLYFWGAKGSSYHVAIATGGGSFIHAPEPGESVKVGSTQYFQPSFAVRVLQ
>NZ_CP011403.1|WP_047034969.1|111904_112294_+|DUF956-family-protein
MVKSLNTKMDMSCKGTWYRNGPFYGNIMVGDNAFEFYNETKLQDYIQIPWDEITYVVADVYFGGKYIPRFEIRTKSNGTFRFSARNSHQTLRAIKARIPRESLRKAPSMGFILKHRFKNLGKMILKKKA
>NZ_CP011403.1|WP_041822588.1|125117_125426_+|PadR-family-transcriptional-regulator
MKIQVSSDLLDGLVLALLDKQDYYGYSLTQDMQRAISISESTLYPVLRRLKNNGLLETYDQSYQGRNRRYYRITNSGEEHLGRVKKMWSDYKVSLDSIFEKN
>NZ_CP011403.1|WP_047034980.1|125441_126047_+|DUF1700-domain-containing-protein
MNSEITKYLQELKRYLRRLDDSEIKDIEDFYTEYLEDAGVQTRAEIEEKVGTPRQLSLRILADYSLKDDGKESGGILPKTNIKTAWLIILALLATPATLIIGVALLGVLVAAIGVAFAVAVTIIALAGAAIFITLTSLYVGIFLLFTKLGVGLFYLGIGIIGIGALMVILPIIYLIIVTVVKMVANFIRYIYRRFNKKGVR
>NZ_CP011403.1|WP_011475526.1|126049_127015_+|DUF4097-domain-containing-protein
MKKTIISGFIISIIGAILLAIGLGLKGNKSIVFEDLKPVIADSTKVTQAHTYKDINKLDIDVKDVNVEFREGKNYSVRYEGAKSSSPTVKKSGNQLQIKGRLSSHSIRFNGMSMYDDYYRNSDRNKMIITLPKDSKLDELNLKLSDSLLSQVNMTGIEADRVKASIHDTKLDLRDANFGNVELSAGDSDISMTNTVLSNGKLDLNDTDVRLDGGSLMQVAMNITEGDVDYNNLSIQGGNLRNNDGDIKMSNTQIQGGYKIDDTDGDILVSRVTVDGYRVQSNDGDVRLFEQTTSNGNVLEKNSNSDNVLDIISNDGDITVN
>NZ_CP011403.1|WP_003704561.1|127033_127264_+|PspC-domain-containing-protein
MKKLTKSNDKVLTGVLGGFAEYFGADKALVRIIGAALMMVTGFFPGVFLYIIAAVIMPEKTDKDNDDVIEGEFHEK
>NZ_CP011403.1|WP_047034983.1|127602_127914_+|bacteriocin-immunity-protein
MEKVQELQRLVAELYDSFENDNRKGVEEIRQVLANVNEKYKTSSHPLAWTGRLVLYLQVNAVKKDLYLTSEQKDIIKELARIGKRTNLNYVYLSPVDDAKQFV
>NZ_CP011403.1|WP_003700771.1|128315_129830_+|glycerol-kinase-GlpK
MSDKYIMAIDEGTTSTRAIIFDKKGNKVAEGQKEFRQYFPQPGWVEHDANEIWNAVLSTIANSFISSGIQPKQIAGIGITNQRETTIIWDKETGLPIYNAIVWQSRQTSDIAQKLIDEGYSDTIHEKTGLIIDAYFSATKIRWILDHVEGAQERAEKGELLFGTIDTWLTWKLTGGKVHVTDYSNASRTMLFNIHDLKWDKEILELLNIPEALLPEVKGNSEIYGQTAAYHFFGSQVPISGMAGDQQSALFGQLALEDGTVKNTYGTGSFIVMNTGNKPVLSKNNLLTTIGYSIDGKINFALEGSVFVSGSALQWLRDSMEIIESAPESERAANESTNHNEVYVVPAFTGLGAPYWDSDARGAVFGLTRGTTKNDFIKATLQSLAYQTRDVLDTMEKDTGIKIPVLRVDGGAAMNNYLLQFQSDLLNKSVERAGNLETTALGVAFLAGLAVGFWKDTDELKELFTVGRRFEPEMSDDAREYLYAGWKNAVEATRIFKHKINENL
>NZ_CP011403.1|WP_011475529.1|129842_131672_+|type-1-glycerol-3-phosphate-oxidase
MTFSIKTRKNTVDKLKNEELDLLVIGGGITGAGVALQATASGLKTGLVEMQDFAEGTSSRSTKLVHGGIRYLKTFDVGVVADTVQERAVVQGIAPHIPRPFPMLLPIYDDPSSTFDMFSVKIAMDLYDRLAGVTGTQYANYTISREEVLQREPNLKSDKLLGAGVYLDYVNNDARLVIENIKEADELGGLMASHVKVVGVLHDDNGRINGVKAKDLLTDEEFEIKAKMVINTTGPWVTKTLGLDDKNGEGEVIRPTKGVHLVVDSSRLRVPQPTYFDSGIGDGRMIFVVPRENKTYFGTTDTDYTGDYKHPRVEQADVDYLLKAINNRYPEAEITINDIEASWAGLRPLLSGNGSSDYNGGGSNTGKVSDESFENLIKTAVAYSKDEASRGEVEKSISSLKTASAEKTLSPSQVSRGSSLKVGDDGLITLSGGKITDYRKMAAGAMELIRKLFKELFNKDVREVDSKKLQVSGGHFDPTNVDETMKFYQKIAMDKGMPAADAADLANRFGSNTSRVISYADDVEAAPGLTLADTLSLHYSVNEEMTLNLVDFLLRRTNYVLFHKDELMMKKDAFVDEMARIMEWNEEEKAAAAKQLDETIAESSLAYLK
>NZ_CP011403.1|WP_047034984.1|131707_132415_+|aquaporin-family-protein
MNGFLGEFLGTMVLIVLGVGTGAGVNLKTSYARNSGWLFITIAWGMAVTFGVYVAGSFGSQGHLNPAVTIPFAIFGFFPWDQVLPYLLGQFLGAFVGAVLVIIQYGAQFKNAKDANDGNVVGIFATGPAINNGLYNFLSETIATFVFILTLLNLGDFTKGLKPLIVGLLIMVVGQALGGTTGFALNPARDWAPRFAYSVLPVPNKGDSNWSYAWVPMFGPLAGGLIAACVQYFLM
>NZ_CP011403.1|WP_047034985.1|132533_133622_+|ABC-transporter-ATP-binding-protein
MKQPLISFKHVVKSYDDDVQVLKDVSFDIEEGKFYTLLGPSGCGKTTILNIIAGLSDATSGDVYFDGKRINDVPANKRQVNTVFQDYALFQHLNVYDNIAFGLKIKKVPADKIKEKVTEALRMIRLDGYEDRAISEMSGGQRQRVAIARAIVLDPKVLLLDEPLSALDQKLRTEMQYELRSLQKKLGITFIFITHDQEEALAMSDEIFVLNNGNIVQSGTPVDIYDEPINHYVADFIGESNIVNGIMIKDELVEFAGQQFPCVDGGMKPNEPVEVVIRPEDLVLTSPEKGQLKVKVDTQLFRGVHYEIRCTDALGNKWLVHSTKRAVPGENIGLSFGPEDIHVMRFNESEEDFDARLDSYND
>NZ_CP011403.1|WP_047034986.1|133639_134440_+|ABC-transporter-permease
MKKINPLLTIPYYLWIGLFVIAPVLLIVYYSFIDIHGNFTLSNYGNYFGSGKYLMMTFNSFLYAFIITFFTVLVSYPMAYFLTKLKHKELWLLLVILPTWVNLLLKAYAFIGIFGIDGSVNHFLSFFGIGPKQILFTDFSFIVVATYIQIPFMIMPIFNALEEINPSVLRASRDLGANEWQTFFKVVMPLSMNGVKSGIQAVFIPSLSLFMLTRLIGGNRVITLGTAIEEHFLVTQNWEMGSTIGVVLIVIMFIVMVITGEKRGHK

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Crispr_ID: NZ_CP011403_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011403_2

772733-774023

TypeIII

Consensus_repeat	Method
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	PILER-CR
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CRISPRCasFinder
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CRT

17 spacers

cas2,cas1,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,csm6

The CRISPR arrays of NZ_CP011403_2

>merge|NZ_CP011403|2|772733-774023|PILER-CR,CRISPRCasFinder,CRT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAACAAAGAATGGTTTTTTTGCATCCTTTGCCGGTTGCTTTAATTGAAGTAAGAACATATCTCCGAATATAGGAGACGAAAACTTAGCTGAGAAATTACTGGAGAAAGATCCAGTATTGGCTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACTACTACTGAATTTCCATTGCCGTCTTTTGTTACTTTGAAGTAAGAACATATCTCCGAATATAGGAGACGAAAACTACTTTGACTGCAAATACCGTATCATGGATTTTGCTTTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACATCAAGCCATTATTCATAACTACATGTAGATGTGGTGGAGTAAGAACATATCTCCGAATATAGGAGACGAAAACCAGCTAAACCAAAAATTTTTTCAATCATGATAATAGTAAGAACATATCTCCGAATATAGGAGACGAAAACTTTGCATTTTAATTAATTGATTCATGTTTACTTCCAGTAAGAACATATCTCCGAATATAGGAGACGAAAACATGAATTTTGATAACAGTAAGGAAGAAGATATAGAAGTAAGAACATATCTCCGAATATAGGAGACGAAAACTCTTACTCATTTCAATCGCTCCTTTTAGTTTTGCAAGTAAGAACATATCTCCGAATATAGGAGACGAAAACTTTAGTGAATTCTATTTCCATTTTTTATTTCTCCTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACAACAATGTAACGTGGTACAATTTGTGATACATCTTTCAGTAAGAACATATCTCCGAATATAGGAGACGAAAACGATTTATTTAGTTTTAAAAAGAACTGTTTTTGTACCGCCAGTAAGAACATATCTCCGAATATAGGAGACGAAAACGACTTGATCGAACAACTTTATTAAATCATAAGCACTTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACACGACAGCCTAATACCAGAGCTACTCCTTTCATTTAAAGTAAGAACATATCTCCGAATATAGGAGACGAAAACTTCGTTCATTAGGTTTATCAATCTTTCATCAAATTTCATTTTAGTAAGAACATATCTTCGAATATAGGAGACGAAAACTTACCACCAGAAAAAGCAACTAAGATATTATCAAATTCATTAGTAAGAACATATCTCCGAATGTAGGAGACGAAAACCCTGCTGTTGTTAGTTCGATCATTTTTCTTCATCCTTTCGAGTAAGAACATATCTCCGAATATAGGAGCTTGAATC

>NZ_CP011403|2|2|772733-773792|PILER-CR
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AAAGAATGGTTTTTTTGCATCCTTTGCCGGTTGCTTTAATTGA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTAGCTGAGAAATTACTGGAGAAAGATCCAGTATTGGCT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TACTACTGAATTTCCATTGCCGTCTTTTGTTACTTTGA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TACTTTGACTGCAAATACCGTATCATGGATTTTGCTTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ATCAAGCCATTATTCATAACTACATGTAGATGTGGTGG
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CAGCTAAACCAAAAATTTTTTCAATCATGATAAT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTTGCATTTTAATTAATTGATTCATGTTTACTTCC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ATGAATTTTGATAACAGTAAGGAAGAAGATATAGA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TCTTACTCATTTCAATCGCTCCTTTTAGTTTTGCA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTTAGTGAATTCTATTTCCATTTTTTATTTCTCCT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AACAATGTAACGTGGTACAATTTGTGATACATCTTTC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GATTTATTTAGTTTTAAAAAGAACTGTTTTTGTACCGCC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GACTTGATCGAACAACTTTATTAAATCATAAGCACTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ACGACAGCCTAATACCAGAGCTACTCCTTTCATTTAA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC

>NZ_CP011403|2|2|772733-774023|CRISPRCasFinder
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AAAGAATGGTTTTTTTGCATCCTTTGCCGGTTGCTTTAATTGA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTAGCTGAGAAATTACTGGAGAAAGATCCAGTATTGGCT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TACTACTGAATTTCCATTGCCGTCTTTTGTTACTTTGA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TACTTTGACTGCAAATACCGTATCATGGATTTTGCTTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ATCAAGCCATTATTCATAACTACATGTAGATGTGGTGG
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CAGCTAAACCAAAAATTTTTTCAATCATGATAAT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTTGCATTTTAATTAATTGATTCATGTTTACTTCC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ATGAATTTTGATAACAGTAAGGAAGAAGATATAGA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TCTTACTCATTTCAATCGCTCCTTTTAGTTTTGCA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTTAGTGAATTCTATTTCCATTTTTTATTTCTCCT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AACAATGTAACGTGGTACAATTTGTGATACATCTTTC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GATTTATTTAGTTTTAAAAAGAACTGTTTTTGTACCGCC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GACTTGATCGAACAACTTTATTAAATCATAAGCACTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ACGACAGCCTAATACCAGAGCTACTCCTTTCATTTAA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTCGTTCATTAGGTTTATCAATCTTTCATCAAATTTCATTTT
AGTAAGAACATATCTTCGAATATAGGAGACGAAAAC	TTACCACCAGAAAAAGCAACTAAGATATTATCAAATTCATT
AGTAAGAACATATCTCCGAATGTAGGAGACGAAAAC	CCTGCTGTTGTTAGTTCGATCATTTTTCTTCATCCTTTCG
AGTAAGAACATATCTCCGAATATAGGAGCTTGAATC

>NZ_CP011403|2|2|772733-774023|CRT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AAAGAATGGTTTTTTTGCATCCTTTGCCGGTTGCTTTAATTGA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTAGCTGAGAAATTACTGGAGAAAGATCCAGTATTGGCT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TACTACTGAATTTCCATTGCCGTCTTTTGTTACTTTGA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TACTTTGACTGCAAATACCGTATCATGGATTTTGCTTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ATCAAGCCATTATTCATAACTACATGTAGATGTGGTGG
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CAGCTAAACCAAAAATTTTTTCAATCATGATAAT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTTGCATTTTAATTAATTGATTCATGTTTACTTCC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ATGAATTTTGATAACAGTAAGGAAGAAGATATAGA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TCTTACTCATTTCAATCGCTCCTTTTAGTTTTGCA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTTAGTGAATTCTATTTCCATTTTTTATTTCTCCT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AACAATGTAACGTGGTACAATTTGTGATACATCTTTC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GATTTATTTAGTTTTAAAAAGAACTGTTTTTGTACCGCC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GACTTGATCGAACAACTTTATTAAATCATAAGCACTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ACGACAGCCTAATACCAGAGCTACTCCTTTCATTTAA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTCGTTCATTAGGTTTATCAATCTTTCATCAAATTTCATTTT
AGTAAGAACATATCTTCGAATATAGGAGACGAAAAC	TTACCACCAGAAAAAGCAACTAAGATATTATCAAATTCATT
AGTAAGAACATATCTCCGAATGTAGGAGACGAAAAC	CCTGCTGTTGTTAGTTCGATCATTTTTCTTCATCCTTTCG
AGTAAGAACATATCTCCGAATATAGGAGCTTGAATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011403.1\|WP_047035570.1\|762526_763417_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP011403.1\|WP_003700129.1\|775492_776149_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP011403.1\|WP_047035572.1\|763430_765035_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226089
NZ_CP011403.1\|WP_014568368.1\|781453_781942_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011403.1\|WP_047035587.1\|781271_781457_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011403.1\|WP_014568369.1\|782076_782838_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NZ_CP011403.1\|WP_034983391.1\|769428_770331_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	csm4gr5	COG1567_csm4gr5_CAS-III-A	gnl\|CDD\|380071
NZ_CP011403.1\|WP_003700135.1\|782946_783471_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NZ_CP011403.1\|WP_003710043.1\|780184_780394_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011403.1\|WP_052757133.1\|770347_771340_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl\|CDD\|187793
NZ_CP011403.1\|WP_003704358.1\|783612_783960_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP011403.1\|WP_047036078.1\|766006_768298_+\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl\|CDD\|187811
NZ_CP011403.1\|WP_047035574.1\|768759_769425_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815
NZ_CP011403.1\|WP_180376504.1\|765239_765974_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_CP011403.1\|WP_047035578.1\|771364_772273_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NZ_CP011403.1\|WP_080951846.1\|774290_775340_+\|CRISPR-associated-protein-Csm6	csm6	cd09699_csm6_CAS-III-A	gnl\|CDD\|187830
NZ_CP011403.1\|WP_049176028.1\|768299_768740_+\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	cd09647_csm2gr11_CAS-III-A	gnl\|CDD\|367635
NZ_CP011403.1\|WP_047035584.1\|776825_779300_+\|ATP-dependent-RecD-like-DNA-helicase	unknown	unknown	gnl\|CDD\|273632
NZ_CP011403.1\|WP_047035582.1\|776164_776833_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP011403.1\|WP_003704026.1\|772275_772581_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09638_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|273699

Protein	Function_ID	Function_description	E-value
NZ_CP011403.1\|WP_047035570.1\|762526_763417_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	9.48687e-87
NZ_CP011403.1\|WP_003700129.1\|775492_776149_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.65377e-67
NZ_CP011403.1\|WP_047035572.1\|763430_765035_+\|ABC-transporter-permease	gnl\|CDD\|226089	COG3559, TnrB3, Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane].	5.73783e-83
NZ_CP011403.1\|WP_034983391.1\|769428_770331_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	gnl\|CDD\|380071	pfam17953, Csm4_C, CRISPR Csm4 C-terminal domain. Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci play a pivotal role in the prokaryotic host defense system against invading genetic materials. The CRISPR loci are transcribed to produce CRISPR RNAs (crRNAs), which form interference complexes with CRISPR-associated (Cas) proteins to target the invading nucleic acid for degradation. The interference complex of the type III-A CRISPR-Cas system is composed of five Cas proteins (Csm1-Csm5) and a crRNA, and targets invading DNA. This entry represents the C-terminal domain found in Csm4. Csm4 structurally resembles Cmr3, a component of the type III-B CRISPR-Cas interference complex. Studies indicate that Csm3-Csm4 complex binds single-stranded RNA in a non-sequence-specific manner. Structural analysis show, Csm3 and Csm4 have one and two ferredoxin-like folds (also known as an RRM-like fold), respectively. The long beta-hairpin inserted into the C-terminal ferredoxin-like fold of Csm4, is well-conserved in the Cmr3 structure. The corresponding beta-hairpin of Cmr3 binds the D1 domain of Cmr2, as observed in the Cmr2-Cmr3 complex structure. Furthermore, it is suggested that the hairpin of Csm4 is responsible for the interaction with Csm1 (ortholog of Cmr2).	2.24935e-30
NZ_CP011403.1\|WP_003700135.1\|782946_783471_+\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	8.04972e-18
NZ_CP011403.1\|WP_014568369.1\|782076_782838_+\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	3.43145e-70
NZ_CP011403.1\|WP_052757133.1\|770347_771340_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl\|CDD\|187793	cd09662, Csm5_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.05715e-17
NZ_CP011403.1\|WP_003704358.1\|783612_783960_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.33498e-26
NZ_CP011403.1\|WP_047036078.1\|766006_768298_+\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	0
NZ_CP011403.1\|WP_047035574.1\|768759_769425_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.85615e-85
NZ_CP011403.1\|WP_180376504.1\|765239_765974_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	7.98542e-11
NZ_CP011403.1\|WP_047035578.1\|771364_772273_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	1.81467e-88
NZ_CP011403.1\|WP_080951846.1\|774290_775340_+\|CRISPR-associated-protein-Csm6	gnl\|CDD\|187830	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems.	1.50057e-51
NZ_CP011403.1\|WP_049176028.1\|768299_768740_+\|type-III-A-CRISPR-associated-protein-Csm2	gnl\|CDD\|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	3.09541e-16
NZ_CP011403.1\|WP_047035584.1\|776825_779300_+\|ATP-dependent-RecD-like-DNA-helicase	gnl\|CDD\|273632	TIGR01448, recD_rel, helicase, putative, RecD/TraA family. This model describes a family similar to RecD, the exodeoxyribonuclease V alpha chain of TIGR01447. Members of this family, however, are not found in a context of RecB and RecC and are longer by about 200 amino acids at the amino end. Chlamydia muridarum has both a member of this family and a RecD. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP011403.1\|WP_047035582.1\|776164_776833_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	5.22233e-09
NZ_CP011403.1\|WP_003704026.1\|772275_772581_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|273699	TIGR01573, cas2, CRISPR-associated endonuclease Cas2. This model describes most members of the family of Cas2, one of the first four protein families found to mark prokaryotic genomes that contain multiple CRISPR elements. CRISPR systems protect against invasive nucleic acid sequences, including phage. Cas2 proteins have been characterized as either endoribonuclease (for ssRNA) or endodeoxyribonuclease (for dsDNA), depending on the system to which the Cas2 belongs. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats. The cas genes usually are found near the repeats. A distinct branch of the Cas2 family shows a very low level of sequence identity and is modeled by TIGR01873 instead of by this model (TIGR01573).	1.56102e-16

>NZ_CP011403.1|WP_003704026.1|772275_772581_+|CRISPR-associated-endonuclease-Cas2
MMLLVCFDLPRDTKENRKEATKYHKKLVELGFTMKQFSVYEREVRQNSTRDRVIKVLKDRLPKSGAITLYLLPNEVNDSQITILGSESIKKTVRKPQFIVL
>NZ_CP011403.1|WP_047035578.1|771364_772273_+|type-II-CRISPR-associated-endonuclease-Cas1
MRDIIYIENKHFVGITKDSFKLKNVVDETERYFPFDEVDYLIFDSHSSFISERVITTCVENNIGLIFCDKTHTPQLLMTSIYGQNERFKRQSKQLAMSKKTKGRIWQKIIKTKINNQADCLKYIVKKDETSDIVRSIGKTVTEGDKNNHEAYAARVYFSNLFGKSFKRGRYDDIINSSLNYGYAILRSAIRKELVIYGLEPSWGIHHVSTENPFNLSDDIIEVYRPFLDALVVELLNNNESEELDIELKKEIIKVLFEKCVVDNKVYSLLDAIKVTIKSFVSCVDKNSATGLKLPTFIEEGR
>NZ_CP011403.1|WP_052757133.1|770347_771340_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MLKRQDYEFVLYTLAPVHIGSGVKVTSKESIQENGEYYFPEMDKLYLFLEKNHPESLPAFEQYLLDSGSKTNKRKSRLIDFLNDQKIKERDFGGFKIKQNNLVERLNEVSLFARDGLGRRYIPGSSLKGAIRTILESEYFRGKQISWGAKSGQQFDDIFNNIRVGDSNTIGESNFSIVQKWDYARNKDPKPMPIYRESLQPLKKITFNISAVGEEAISLIDNLENIAEKHYLYYRKFFLDNNFDKKYIQNNIKAPIYLGAGSGIWTKTNIRQMDDEKINAIRRKQYVKMRMKDKGVMKLTKYPTNVNSKIVKTKNFYEMGKCNFEVKKKS
>NZ_CP011403.1|WP_034983391.1|769428_770331_+|type-III-A-CRISPR-associated-RAMP-protein-Csm4
MEVQAYKLDFQTVHFGNGNLNESIGSFNASRLYSALFLESLKLNVDKEFLDLSKSDNFFLSDSFPLKDGEFYLPKPIGYPKMPLISESTKEMQRNAKKSKKLQYIKYTDIEDYVKGNCDIGKLEGISSFFSKSTVVTKKGIDPYEVGITNFKTSLYILTIKHELLDMLMNSLQYSGIGGKRSSGYGRFTIEKLDIPNEFSKNIVINDSEYGVYMTLNTSIPNNDELDVVLPTAEYLLEKSSGFAYSTASKSLLRKQDLYKFVVGSTLTKTYSGNIFDVRPDGFPHPVWNYAKGLFYKLPY
>NZ_CP011403.1|WP_047035574.1|768759_769425_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MLNKLKIEGTIKVESGLHIGGSTEFAAIGAIDSPVIKDSLTNLPIIPGSSLKGKMRTLLAKAYNDSPLVSGTSANNDDYRIKRLFGATTQNADGQLIIGRLIFRDSILSNREELAQLGAKSYTETKFENTIDRFTAVATPRQIERIIRGSKFDFELIYDVEKESEVEEDIQLVKTGLELLENDYLGGSGSRGYGKVKFENLSIKPVLGNYDVKGLDAILEG
>NZ_CP011403.1|WP_049176028.1|768299_768740_+|type-III-A-CRISPR-associated-protein-Csm2
MYNKRKPQGNYDKIVNQKFSLKFTDESYVNEAKDVIEIFKEENFKVNRDTLTNTQLRNLLAMTSAVYDEARNNGFDSVNEKIAYLKVQFIYQSGRNTAVKAFIEVAQLVELVDMIRDFKELDDLLRFCHYMEALIAYFKYYGGSDK
>NZ_CP011403.1|WP_047036078.1|766006_768298_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MNSLFYGSVLHDIGKIVQRSTNERITHSRIGVNYLRKFTDNIDILHQVNYHHVKEINGAKLENNDLAFITYIADNIASGTDRRKIETDTKRQWDSKTNLEDIFDRFGENSTRRYIVPSMLSEDTSKIFPVKDKVEFNSSEYTKIVTRITNTLSVINFAPDYQQSVLNLIEATASFIPSSTNVQESVDVSLYDHMRLTAGIACAIYLFLEEKQEYNYKNTLYNNSQNFYRQNAFKLVSFDISGIQKFLYTITTSGAHKQLRSRSFYLDMISETIVDSLLSKLGLSRANVIYSGGGRAYLVLPNTKSADKAIKEVEKEFNQFFIDKFNIQLYVSFGSSIFTANDLMDKKDNDEDNEKIYNSIFREVSHQISERKLSRYDVSTIKQLNMGGKKVGRECIICHSVDNLVEGENKCQLCFSLENFSSDLQKEKYFVVDDEVSGLQIGPNMYIHKVSEEDIKSGKVNGKIYTKNEFVTGADQSIRLMMGDYSYLHNNEFGKYSDRDWTKVDSSSSPVGIKRIAALRCDVDDLGYGFIGGFKEQNSGKYNTFSRIATFSRRMSIFFKTYINSFAKDKRLTIVYSGGDDVFVLGAWDEVIEFAIDLRQKFISWTDGKLTLSAGIGMFDSKTPINVIARETGTLEDAAKDNDKNSIALFDTKYTFNFDYFIDNVYNSKLSYIKEFFENQPEQGKTFIYRLLDLIYNRDTKDKISFARIAYTLAKAEESISKDKLENFTDFKSKMLNWFEDEEEILSTELALMLYIYQIRKDR
>NZ_CP011403.1|WP_180376504.1|765239_765974_+|CRISPR-associated-endoribonuclease-Cas6
MKKVTFICNKKQKFSYHLGSQFHGWLMENISEEAADYLHESKINCYSISVSNDDKNVYFTINLLNEVAEKIFSYLVLDKEIDKIVLNNSIQKEFLVLNKQIEELTAKQLTRNFYEGISSREVVVDVMSPMSFKVQGDYYFFPDLELMFRNLMQKYNATFENTIIVDNDLLQEILENSKIVSYKIQSSYYPIHKAFIPGTIGRIKIRFKGNQTLTNYTQMLLNFGVFSGIGVKTGMGMGHISIDK
>NZ_CP011403.1|WP_047035572.1|763430_765035_+|ABC-transporter-permease
MKRRFTHTFMLLIFQLRQKWLWLCLWLIGVTAFASGYVSAFEKIAEDQGKVGLFITMKNPAMAAIVGPLPVKSASQYSVGVMYGHEMTLFIAVITMIIAGSFMIDQTRKMEENGQLEILKSLHIGSQASSMATNLLVLLHTVLTIILVSGILVSYNVSSIDLKGSLYFACSLGLASLLGASIAYLCAQIFATSSQARGIFFSIVGILYVLRAGTDVSNLILSKFNPLAWTYLGHPFYQNDWYYLIGLFLLTLVVFSIGLVLESSRDLGSSTITSKKGKIKASKWLATPLGFFFYLNRSTIISWLLADGVIALMYGSIYGDIDTFVSSNKLISQMFANDSATLINSFTALIMVVTTAISLVMPLVVVHKVQSETNKERLGYLLVQRVSRLKVYYSSLILALFFGTLAILINGFCLGIAAVSSMQANNGKFITTCIQAALNQWPLVCLFVGLMLLSLSLPIFVSWLVCGLLGYSFCVTYFAVLLDLPKWMTHTSLFNVLAKMPMEKFDLMSFAILTGIGILAMLLGGILYTRKEIV
>NZ_CP011403.1|WP_047035570.1|762526_763417_+|ABC-transporter-ATP-binding-protein
MKPIVKIENLAKRFGKIYALKDVSFEIYPGEVVGFIGPNGAGKSTTIRIMLGLLKKSRGIVSLFDKDAWRDSLDIHRSVAYVPGDLTLWENLTGGQTIDLLMKLHGNGDETKKQELVKKFNLDLSKKVKSYSKGNRQKVGLIAALAVDCDLYILDEPTSGLDPLMESIFQDEIARLKKQQKAVLLSSHILSEVERLADRVVIIQEGSVVESGTLEELRHLTRSTIHLKVTNEVTPLSILHFIHDWSQIDQNQATFSIDHQSMDNLLQVLTEYQIQKLEILPPTLEELFMRHYQVQK
>NZ_CP011403.1|WP_080951846.1|774290_775340_+|CRISPR-associated-protein-Csm6
MKKDERLISDSEVFIFDKIYEILNNVVLKYSRDNEDLILNLSSGTPQMKSALFTINRLNDINVRAYQVITPSHSSNEGIGHDNNLDINYLISTNLDNRKDFEKRILEDKAEKFQKTLIKRTMKDLLTNFDYESLYNLSMKHRVLSKSKMKKVISLLQDLTEAVKYQKLLKVVNQTDYCEKEKKLINSYLIILLQANRELVSEVLIRSKNIGEYACELYLEKNYPDLIFWKENRPYLNSENYPNIEDKLLNNEDIHYRKEQYLNIHLYIKILEELNENEELIESLNKLSGYNQQRNKVAHGLSEIPASQVNVRKIVNLCYQIVDGCVDLKEDWSKFYDQFNNEISTMLDE
>NZ_CP011403.1|WP_003700129.1|775492_776149_+|histidine-phosphatase-family-protein
MTRLFFVRHGKTEWNLEGRYQGAHGDSPLLPQSLEEIKQLSEYLKTYRFAKIYSSPIKRALVTAQKIKENLPYNVRLEADAAFSEFNLGKMEGMKFTEVAEKYPAELDAFRNHPDKYDPTTIEGESFPELFARMTPKIRDIVKRYPNDDILIVSHGAALCAEIRYLQGIPLEKIRAKGGLANTSTTILQTVDDNQKFKCLVWNKTDYLKRDLDATDVV
>NZ_CP011403.1|WP_047035582.1|776164_776833_+|tetratricopeptide-repeat-protein
MDKNIKNKAEELIKDLIQKIDNNPYDAQAYYNLGVALNDAHSAEQAEELFKKALNIFANSKEKSSLMHYGLGNVYYTNSMYDKAIVEFKKVQSEKLKQDSMLMMAQAYYAQENYPQAMMYALTVSENTKHNVDAISLLASCFMATGDLTNARKYYLKALEYDKDNVEVLFQLGVIELSLSGEAGKYFDRVKNLDNEYYKKMQQRLADVQRFLMTQKKGKSDE
>NZ_CP011403.1|WP_047035584.1|776825_779300_+|ATP-dependent-RecD-like-DNA-helicase
MSEELDLFAQEDNGKYLIGTVNAVYFEASDSFYKVLQVLIKETNFDWDDQRITVTGSFANIQTDSLYRFEGNVVEHQRYGKQFQAESYQLELPSTKDGVITYLSSDEFVGIGKKTAEKIVKKLGVDAIDVLNNDMDKLEELGLSEKQKDSIKKVLKENYGIDKIIIELNSLGFTSTMAGRIYNNYTNSTLEIIHEDPYRLSVDIDGISFTKADQIAQQFGFASDSPGRIRGAIFQSLYDLTYATGNTYVELKPLVTETLKLLESNRNEAIDPQLVADQLIKLAEEDKIKSDDNKVYSRTFFNAEWNIAENLYRLLKLGNSDLPNNDALLDKLLIKAEDQLGIDYDSEQKRAIKDAIKSPVFLLTGGPGTGKTTIINGIVAVYALLNDIDLDIGKYDKDNPFPILLAAPTGRAAKRMAESTGLPASTIHRMLGINAHDDKLPEDIQELEGALLIVDETSMVDTLIMDLLLNSIPSHMQVIFVGDRNQLPSVQPGQVFSDLLVSDTLPKKELTKIYRQGEGSSIINLAHSIKNGELPADFTKAQSDRAFIPCEAGQLTSAVEQVVKAALNKGNSKDDIQVLAPMYRGNAGINRLNTILQELLNPAKPRQKEVIFNEQIFRIGDRVLHLVNDPENNVFNGDIGKIMGINIPKTKKDKKGEQIIADFDGNEVTFDKKDWINLTLAYCMSIHKSQGSEFPIVVLAMLPQYQRMFARNLLYTGITRAKQKLVLLGNISSFRQSAEIISLNRKTGLLKRIRMEFGVEGKPVEKTDNEEVAVNNNKEQDSIVEEQDEPFIYNDGILTMDIIVNNKVDAMIGMDDITPYDFME
>NZ_CP011403.1|WP_003710043.1|780184_780394_-|hypothetical-protein
MINLNSKDIMTAQEAAKIWNKNEAYVRTALRQNPDKFPEGSVKRFGKVILVTTQGMEAVTGIKDPRKDD
>NZ_CP011403.1|WP_047035587.1|781271_781457_+|hypothetical-protein
MGILFLILGIWIAWKILKVAGKLFYWIFCIALFVWLVSHLWLLGLIFIIAAIGGIYALARN
>NZ_CP011403.1|WP_014568368.1|781453_781942_-|hypothetical-protein
MMQLYRLVIDGALVSDESDEYIYIIHISYPSYAYLPDQNMPSIPAKSPALQTIISPVQFEIENGDFSELFVYLNIIPNSLIPRPRFKLDLLKNPDSYSITKHEMKFYNNPDFVEKYGRPRYDVNPIPVNYNVSLAEILPELEHGDFLGNYISIRWELVSHRN
>NZ_CP011403.1|WP_014568369.1|782076_782838_+|RNA-methyltransferase
MEITSTSNSRVKEWKKLNTKKGRKRQNKYILDGLHLVKEALKANKKVEELLITSKFEHLNEIEIPDETKVIMISEEVSKSISETQTPQGIFGIVSIEEEKITYPQKDVGAWLMLDGVQDPGNIGTMVRTADAAGFSGVILGEGSADLYNPKVVRAMQGSQFHIKVINDNLSGWIRHFKDMKVPVFGSELNEHAREYTNVGQHTDFALVMGNEGNGMSKEILEMTSINLYIPITNAESLNVAVAAGILMFALKK
>NZ_CP011403.1|WP_003700135.1|782946_783471_+|HD-domain-containing-protein
MKDNIWRNDEEYMSYVGSLLETKEVQKLANYTQHHFSTRLEHVITVSYVSYRIAKTLGWNAKAVARAGLLHDLFYYDWRTTKFDRGTHAWIHPRIAVRNAEKLTKLSDLEKDIIIKHMWGATLCPPKYKEGYIVTIVDKYSATAEYSEHLVQKVEKLFRGRKNSTAFDFEKVSK
>NZ_CP011403.1|WP_003704358.1|783612_783960_+|helix-turn-helix-transcriptional-regulator
MPVDTENKYTLCPKFTKTFGILGRKWNGLIIEVLLEKGPQRFRNLADSVDKCSDRVMVERLKELEDEGLVERMAQPGSTRVLYKLTPQGEDLKEIMSDIHKWSDKWYSVEDCANS

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Identity
NZ_CP011403_1	1.1\|124174\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124174-124203	30	NZ_CP011403.1	355055-355084	1.0
NZ_CP011403_2	2.2\|772848\|39\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	772848-772886	39	NZ_CP011404.1	61858-61896	1.0
NZ_CP011403_2	2.4\|772997\|38\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	772997-773034	38	NZ_CP011403.1	1287026-1287063	1.0

1. spacer 1.1|124174|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to position: 355055-355084, mismatch: 0, identity: 1.0

tagaagaagtgaaaaacaatcttactaatt	CRISPR spacer
tagaagaagtgaaaaacaatcttactaatt	Protospacer
******************************

2. spacer 2.2|772848|39|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to position: 61858-61896, mismatch: 0, identity: 1.0

ttagctgagaaattactggagaaagatccagtattggct	CRISPR spacer
ttagctgagaaattactggagaaagatccagtattggct	Protospacer
***************************************

3. spacer 2.4|772997|38|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to position: 1287026-1287063, mismatch: 0, identity: 1.0

tactttgactgcaaataccgtatcatggattttgcttt	CRISPR spacer
tactttgactgcaaataccgtatcatggattttgcttt	Protospacer
**************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP011403_2	2.2\|772848\|39\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	772848-772886	39	NZ_CP007647	Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence	124482-124520	0	1.0
NZ_CP011403_2	2.2\|772848\|39\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	772848-772886	39	NZ_CP011404	Lactobacillus salivarius str. Ren plasmid pR1, complete sequence	61858-61896	0	1.0
NZ_CP011403_2	2.2\|772848\|39\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	772848-772886	39	NZ_CP020859	Lactobacillus salivarius strain ZLS006 plasmid unnamed1, complete sequence	255860-255898	0	1.0
NZ_CP011403_2	2.2\|772848\|39\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	772848-772886	39	NC_007930	Lactobacillus salivarius UCC118 plasmid pMP118, complete sequence	87563-87601	0	1.0
NZ_CP011403_2	2.2\|772848\|39\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	772848-772886	39	NZ_CP017108	Lactobacillus salivarius strain CICC23174 plasmid pLS_1 sequence	217478-217516	0	1.0
NZ_CP011403_2	2.2\|772848\|39\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	772848-772886	39	NZ_LT604075	Lactobacillus salivarius isolate LPM01 plasmid II	240715-240753	0	1.0
NZ_CP011403_2	2.2\|772848\|39\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	772848-772886	39	CP002037	Lactobacillus salivarius CECT 5713 plasmid pHN3, complete sequence	87791-87829	0	1.0
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP037430	Lactobacillus plantarum strain EM plasmid pEM1, complete sequence	60510-60539	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_KM063576	Lactobacillus reuteri strain LU4 plasmid pLU4, complete sequence	24503-24532	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NC_021225	Lactobacillus plantarum subsp. plantarum P-8 plasmid LBPp2, complete sequence	201-230	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP011405	Lactobacillus salivarius str. Ren plasmid pR2, complete sequence	17945-17974	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP045730	Lactobacillus gastricus strain LG045 plasmid unnamed1, complete sequence	20647-20676	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP019031	Lactobacillus fermentum strain SNUV175 plasmid pSNU175-2, complete sequence	18627-18656	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP035027	Lactobacillus plantarum strain YW11 plasmid plsm_YW11_pB, complete sequence	11473-11502	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP035013	Lactobacillus plantarum strain 12_3 plasmid pldA, complete sequence	10171-10200	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP035022	Lactobacillus plantarum strain 13_3 plasmid plsm_LP12_3_pB	11473-11502	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP018798	Lactobacillus parabuchneri strain FAM21731 plasmid pFAM21731.2, complete sequence	3765-3794	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP017407	Lactobacillus plantarum strain RI-113 plasmid pRI113_1, complete sequence	11096-11125	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NC_006530	Lactobacillus salivarius UCC118 plasmid pSF118-44, complete sequence	25600-25629	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP044413	Lactobacillus sp. JM1 plasmid unnamed1, complete sequence	43124-43153	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NC_011352	Lactobacillus paracasei plasmid plca36, complete sequence	25371-25400	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP046665	Lactobacillus plantarum strain 83-18 plasmid p83-18.5, complete sequence	5091-5120	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP008840	Lactobacillus gasseri DSM 14869 plasmid pEB01-2, complete sequence	35463-35492	3	0.9
NZ_CP011403_1	1.4\|124372\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124372-124401	30	NZ_CP045050	Lactobacillus reuteri strain reuteri plasmid pLTR1318, complete sequence	9485-9514	3	0.9
NZ_CP011403_2	2.7\|773215\|35\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	773215-773249	35	NC_042028	Acinetobacter phage AB1, complete genome	32821-32855	5	0.857
NZ_CP011403_2	2.7\|773215\|35\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	773215-773249	35	NC_041966	Acinetobacter phage WCHABP1, complete genome	45372-45406	5	0.857
NZ_CP011403_2	2.7\|773215\|35\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	773215-773249	35	MH853788	Acinetobacter phage vB_KpnM_IME512, complete genome	26143-26177	5	0.857
NZ_CP011403_2	2.7\|773215\|35\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	773215-773249	35	MF346584	Acinetobacter phage AbP2, complete genome	4461-4495	5	0.857
NZ_CP011403_2	2.7\|773215\|35\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	773215-773249	35	MN516422	Acinetobacter phage Bphi-R1888, complete genome	16684-16718	5	0.857
NZ_CP011403_2	2.7\|773215\|35\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	773215-773249	35	MN516421	Acinetobacter phage Bphi-R2919, complete genome	17613-17647	5	0.857
NZ_CP011403_2	2.7\|773215\|35\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	773215-773249	35	MN166083	Acinetobacter phage Abp9, complete genome	34125-34159	5	0.857
NZ_CP011403_1	1.1\|124174\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124174-124203	30	NC_019735	Crinalium epipsammum PCC 9333 plasmid pCRI9333.04, complete sequence	23488-23517	7	0.767
NZ_CP011403_1	1.2\|124240\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124240-124269	30	NZ_KY362367	Pseudomonas coronafaciens pv. garcae strain 2708 plasmid pPg2708, complete sequence	10782-10811	8	0.733
NZ_CP011403_1	1.2\|124240\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124240-124269	30	NZ_KY362367	Pseudomonas coronafaciens pv. garcae strain 2708 plasmid pPg2708, complete sequence	20165-20194	8	0.733
NZ_CP011403_1	1.2\|124240\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124240-124269	30	CP050261	Pseudomonas coronafaciens strain X-1 plasmid unnamed1	55778-55807	8	0.733
NZ_CP011403_1	1.2\|124240\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124240-124269	30	CP046442	Pseudomonas coronafaciens pv. coronafaciens strain B19001 plasmid unnamed1, complete sequence	69802-69831	8	0.733
NZ_CP011403_1	1.7\|124570\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124570-124599	30	NZ_KY362367	Pseudomonas coronafaciens pv. garcae strain 2708 plasmid pPg2708, complete sequence	10782-10811	8	0.733
NZ_CP011403_1	1.7\|124570\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124570-124599	30	NZ_KY362367	Pseudomonas coronafaciens pv. garcae strain 2708 plasmid pPg2708, complete sequence	20165-20194	8	0.733
NZ_CP011403_1	1.7\|124570\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124570-124599	30	CP050261	Pseudomonas coronafaciens strain X-1 plasmid unnamed1	55778-55807	8	0.733
NZ_CP011403_1	1.7\|124570\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124570-124599	30	CP046442	Pseudomonas coronafaciens pv. coronafaciens strain B19001 plasmid unnamed1, complete sequence	69802-69831	8	0.733
NZ_CP011403_2	2.10\|773428\|35\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	773428-773462	35	MN693220	Marine virus AFVG_25M60, complete genome	58303-58337	8	0.771
NZ_CP011403_1	1.6\|124504\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124504-124533	30	NZ_CP035135	Lactobacillus plantarum strain SRCM103311 plasmid unnamed4	61490-61519	9	0.7
NZ_CP011403_1	1.6\|124504\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124504-124533	30	NZ_CP020095	Lactobacillus plantarum strain K25 plasmid unnamed2, complete sequence	8062-8091	9	0.7
NZ_CP011403_1	1.6\|124504\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124504-124533	30	NZ_CP017698	Lactobacillus coryniformis subsp. torquens DSM 20004 = KCTC 3535 plasmid pLDW-4, complete sequence	9221-9250	9	0.7
NZ_CP011403_1	1.6\|124504\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124504-124533	30	NZ_CP025416	Lactobacillus plantarum strain X7021 plasmid unnamed4, complete sequence	3410-3439	9	0.7
NZ_CP011403_1	1.9\|124702\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124702-124731	30	NZ_CP035135	Lactobacillus plantarum strain SRCM103311 plasmid unnamed4	61490-61519	9	0.7
NZ_CP011403_1	1.9\|124702\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124702-124731	30	NZ_CP020095	Lactobacillus plantarum strain K25 plasmid unnamed2, complete sequence	8062-8091	9	0.7
NZ_CP011403_1	1.9\|124702\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124702-124731	30	NZ_CP017698	Lactobacillus coryniformis subsp. torquens DSM 20004 = KCTC 3535 plasmid pLDW-4, complete sequence	9221-9250	9	0.7
NZ_CP011403_1	1.9\|124702\|30\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	124702-124731	30	NZ_CP025416	Lactobacillus plantarum strain X7021 plasmid unnamed4, complete sequence	3410-3439	9	0.7
NZ_CP011403_2	2.9\|773357\|35\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	773357-773391	35	JN700521	Staphylococcus phage StB20, complete genome	4453-4487	10	0.714
NZ_CP011403_2	2.7\|773215\|35\|NZ_CP011403\|PILER-CR,CRISPRCasFinder,CRT	773215-773249	35	KU892558	Lactococcus phage PLgT-1, complete genome	36695-36729	11	0.686

1. spacer 2.2|772848|39|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007647 (Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence) position: , mismatch: 0, identity: 1.0

ttagctgagaaattactggagaaagatccagtattggct	CRISPR spacer
ttagctgagaaattactggagaaagatccagtattggct	Protospacer
***************************************

2. spacer 2.2|772848|39|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011404 (Lactobacillus salivarius str. Ren plasmid pR1, complete sequence) position: , mismatch: 0, identity: 1.0

ttagctgagaaattactggagaaagatccagtattggct	CRISPR spacer
ttagctgagaaattactggagaaagatccagtattggct	Protospacer
***************************************

3. spacer 2.2|772848|39|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020859 (Lactobacillus salivarius strain ZLS006 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

ttagctgagaaattactggagaaagatccagtattggct	CRISPR spacer
ttagctgagaaattactggagaaagatccagtattggct	Protospacer
***************************************

4. spacer 2.2|772848|39|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NC_007930 (Lactobacillus salivarius UCC118 plasmid pMP118, complete sequence) position: , mismatch: 0, identity: 1.0

ttagctgagaaattactggagaaagatccagtattggct	CRISPR spacer
ttagctgagaaattactggagaaagatccagtattggct	Protospacer
***************************************

5. spacer 2.2|772848|39|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017108 (Lactobacillus salivarius strain CICC23174 plasmid pLS_1 sequence) position: , mismatch: 0, identity: 1.0

ttagctgagaaattactggagaaagatccagtattggct	CRISPR spacer
ttagctgagaaattactggagaaagatccagtattggct	Protospacer
***************************************

6. spacer 2.2|772848|39|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LT604075 (Lactobacillus salivarius isolate LPM01 plasmid II) position: , mismatch: 0, identity: 1.0

ttagctgagaaattactggagaaagatccagtattggct	CRISPR spacer
ttagctgagaaattactggagaaagatccagtattggct	Protospacer
***************************************

7. spacer 2.2|772848|39|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to CP002037 (Lactobacillus salivarius CECT 5713 plasmid pHN3, complete sequence) position: , mismatch: 0, identity: 1.0

ttagctgagaaattactggagaaagatccagtattggct	CRISPR spacer
ttagctgagaaattactggagaaagatccagtattggct	Protospacer
***************************************

8. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP037430 (Lactobacillus plantarum strain EM plasmid pEM1, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

9. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KM063576 (Lactobacillus reuteri strain LU4 plasmid pLU4, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

10. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NC_021225 (Lactobacillus plantarum subsp. plantarum P-8 plasmid LBPp2, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

11. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011405 (Lactobacillus salivarius str. Ren plasmid pR2, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

12. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045730 (Lactobacillus gastricus strain LG045 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

13. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019031 (Lactobacillus fermentum strain SNUV175 plasmid pSNU175-2, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

14. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP035027 (Lactobacillus plantarum strain YW11 plasmid plsm_YW11_pB, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

15. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP035013 (Lactobacillus plantarum strain 12_3 plasmid pldA, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

16. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP035022 (Lactobacillus plantarum strain 13_3 plasmid plsm_LP12_3_pB) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

17. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018798 (Lactobacillus parabuchneri strain FAM21731 plasmid pFAM21731.2, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

18. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017407 (Lactobacillus plantarum strain RI-113 plasmid pRI113_1, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

19. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NC_006530 (Lactobacillus salivarius UCC118 plasmid pSF118-44, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

20. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP044413 (Lactobacillus sp. JM1 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

21. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NC_011352 (Lactobacillus paracasei plasmid plca36, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

22. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP046665 (Lactobacillus plantarum strain 83-18 plasmid p83-18.5, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

23. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP008840 (Lactobacillus gasseri DSM 14869 plasmid pEB01-2, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

24. spacer 1.4|124372|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045050 (Lactobacillus reuteri strain reuteri plasmid pLTR1318, complete sequence) position: , mismatch: 3, identity: 0.9

agccccaggttcctaataatccaacaacac	CRISPR spacer
agccccaggttcctaataacccgacaacgc	Protospacer
*******************.**.*****.*

25. spacer 2.7|773215|35|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NC_042028 (Acinetobacter phage AB1, complete genome) position: , mismatch: 5, identity: 0.857

---tttgcattttaattaattgattcatgtttacttcc	CRISPR spacer
cgatttg---tttaattaattgttccatgtttacttcc	Protospacer
   ****   ************ *.*************

26. spacer 2.7|773215|35|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NC_041966 (Acinetobacter phage WCHABP1, complete genome) position: , mismatch: 5, identity: 0.857

---tttgcattttaattaattgattcatgtttacttcc	CRISPR spacer
cgatttg---tttaattaattgttccatgtttacttcc	Protospacer
   ****   ************ *.*************

27. spacer 2.7|773215|35|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to MH853788 (Acinetobacter phage vB_KpnM_IME512, complete genome) position: , mismatch: 5, identity: 0.857

---tttgcattttaattaattgattcatgtttacttcc	CRISPR spacer
cgatttg---tttaattaattgttccatgtttacttcc	Protospacer
   ****   ************ *.*************

28. spacer 2.7|773215|35|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to MF346584 (Acinetobacter phage AbP2, complete genome) position: , mismatch: 5, identity: 0.857

---tttgcattttaattaattgattcatgtttacttcc	CRISPR spacer
cgatttg---tttaattaattgttccatgtttacttcc	Protospacer
   ****   ************ *.*************

29. spacer 2.7|773215|35|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to MN516422 (Acinetobacter phage Bphi-R1888, complete genome) position: , mismatch: 5, identity: 0.857

---tttgcattttaattaattgattcatgtttacttcc	CRISPR spacer
cgatttg---tttaattaattgttccatgtttacttcc	Protospacer
   ****   ************ *.*************

30. spacer 2.7|773215|35|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to MN516421 (Acinetobacter phage Bphi-R2919, complete genome) position: , mismatch: 5, identity: 0.857

---tttgcattttaattaattgattcatgtttacttcc	CRISPR spacer
cgatttg---tttaattaattgttccatgtttacttcc	Protospacer
   ****   ************ *.*************

31. spacer 2.7|773215|35|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to MN166083 (Acinetobacter phage Abp9, complete genome) position: , mismatch: 5, identity: 0.857

---tttgcattttaattaattgattcatgtttacttcc	CRISPR spacer
cgatttg---tttaattaattgttccatgtttacttcc	Protospacer
   ****   ************ *.*************

32. spacer 1.1|124174|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NC_019735 (Crinalium epipsammum PCC 9333 plasmid pCRI9333.04, complete sequence) position: , mismatch: 7, identity: 0.767

tagaagaagtgaaaaacaatcttactaatt	CRISPR spacer
tgtcagtagtgaaaaacaaacttactattg	Protospacer
*.  ** ************ ******* *

33. spacer 1.2|124240|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KY362367 (Pseudomonas coronafaciens pv. garcae strain 2708 plasmid pPg2708, complete sequence) position: , mismatch: 8, identity: 0.733

tgacgaagctcctaatgactacaaagtttt	CRISPR spacer
tggtaaagctcgtaatgactacaaagcaac	Protospacer
**...****** **************.  .

34. spacer 1.2|124240|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KY362367 (Pseudomonas coronafaciens pv. garcae strain 2708 plasmid pPg2708, complete sequence) position: , mismatch: 8, identity: 0.733

tgacgaagctcctaatgactacaaagtttt	CRISPR spacer
tggtaaagctcgtaatgactacaaagcaac	Protospacer
**...****** **************.  .

35. spacer 1.2|124240|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to CP050261 (Pseudomonas coronafaciens strain X-1 plasmid unnamed1) position: , mismatch: 8, identity: 0.733

tgacgaagctcctaatgactacaaagtttt	CRISPR spacer
tggtaaagctcgtaatgactacaaagcaac	Protospacer
**...****** **************.  .

36. spacer 1.2|124240|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to CP046442 (Pseudomonas coronafaciens pv. coronafaciens strain B19001 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tgacgaagctcctaatgactacaaagtttt	CRISPR spacer
tggtaaagctcgtaatgactacaaagcaac	Protospacer
**...****** **************.  .

37. spacer 1.7|124570|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KY362367 (Pseudomonas coronafaciens pv. garcae strain 2708 plasmid pPg2708, complete sequence) position: , mismatch: 8, identity: 0.733

tgacgaagctcctaatgactacaaagtttt	CRISPR spacer
tggtaaagctcgtaatgactacaaagcaac	Protospacer
**...****** **************.  .

38. spacer 1.7|124570|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_KY362367 (Pseudomonas coronafaciens pv. garcae strain 2708 plasmid pPg2708, complete sequence) position: , mismatch: 8, identity: 0.733

tgacgaagctcctaatgactacaaagtttt	CRISPR spacer
tggtaaagctcgtaatgactacaaagcaac	Protospacer
**...****** **************.  .

39. spacer 1.7|124570|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to CP050261 (Pseudomonas coronafaciens strain X-1 plasmid unnamed1) position: , mismatch: 8, identity: 0.733

tgacgaagctcctaatgactacaaagtttt	CRISPR spacer
tggtaaagctcgtaatgactacaaagcaac	Protospacer
**...****** **************.  .

40. spacer 1.7|124570|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to CP046442 (Pseudomonas coronafaciens pv. coronafaciens strain B19001 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tgacgaagctcctaatgactacaaagtttt	CRISPR spacer
tggtaaagctcgtaatgactacaaagcaac	Protospacer
**...****** **************.  .

41. spacer 2.10|773428|35|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to MN693220 (Marine virus AFVG_25M60, complete genome) position: , mismatch: 8, identity: 0.771

tttagtgaattctatttccattttttatttctcct	CRISPR spacer
gtatatgttttctttttccattttttatttttcct	Protospacer
 *  .**  **** ****************.****

42. spacer 1.6|124504|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP035135 (Lactobacillus plantarum strain SRCM103311 plasmid unnamed4) position: , mismatch: 9, identity: 0.7

agcaactttgactaaacaagttatgcaatt	CRISPR spacer
tgatcggttgactaaacaagttatggaaga	Protospacer
 *     ****************** **

43. spacer 1.6|124504|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020095 (Lactobacillus plantarum strain K25 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.7

agcaactttgactaaacaagttatgcaatt	CRISPR spacer
tgatcggttgactaaacaagttatggaaga	Protospacer
 *     ****************** **

44. spacer 1.6|124504|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017698 (Lactobacillus coryniformis subsp. torquens DSM 20004 = KCTC 3535 plasmid pLDW-4, complete sequence) position: , mismatch: 9, identity: 0.7

agcaactttgactaaacaagttatgcaatt	CRISPR spacer
tgatcggttgactaaacaagttatggaaga	Protospacer
 *     ****************** **

45. spacer 1.6|124504|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP025416 (Lactobacillus plantarum strain X7021 plasmid unnamed4, complete sequence) position: , mismatch: 9, identity: 0.7

agcaactttgactaaacaagttatgcaatt	CRISPR spacer
tgatcggttgactaaacaagttatggaaga	Protospacer
 *     ****************** **

46. spacer 1.9|124702|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP035135 (Lactobacillus plantarum strain SRCM103311 plasmid unnamed4) position: , mismatch: 9, identity: 0.7

agcaactttgactaaacaagttatgcaatt	CRISPR spacer
tgatcggttgactaaacaagttatggaaga	Protospacer
 *     ****************** **

47. spacer 1.9|124702|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020095 (Lactobacillus plantarum strain K25 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.7

agcaactttgactaaacaagttatgcaatt	CRISPR spacer
tgatcggttgactaaacaagttatggaaga	Protospacer
 *     ****************** **

48. spacer 1.9|124702|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017698 (Lactobacillus coryniformis subsp. torquens DSM 20004 = KCTC 3535 plasmid pLDW-4, complete sequence) position: , mismatch: 9, identity: 0.7

agcaactttgactaaacaagttatgcaatt	CRISPR spacer
tgatcggttgactaaacaagttatggaaga	Protospacer
 *     ****************** **

49. spacer 1.9|124702|30|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP025416 (Lactobacillus plantarum strain X7021 plasmid unnamed4, complete sequence) position: , mismatch: 9, identity: 0.7

agcaactttgactaaacaagttatgcaatt	CRISPR spacer
tgatcggttgactaaacaagttatggaaga	Protospacer
 *     ****************** **

50. spacer 2.9|773357|35|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to JN700521 (Staphylococcus phage StB20, complete genome) position: , mismatch: 10, identity: 0.714

tcttactcatttcaatcgctccttttagttttgca	CRISPR spacer
aacttttcatttcattcgctccttttattttcgtc	Protospacer
  .* .******** ************ ***.*.

51. spacer 2.7|773215|35|NZ_CP011403|PILER-CR,CRISPRCasFinder,CRT matches to KU892558 (Lactococcus phage PLgT-1, complete genome) position: , mismatch: 11, identity: 0.686

tttgcattttaattaattgattcatgtttacttcc	CRISPR spacer
gtgtgatattaattaattgattcatttttatgaat	Protospacer
 *   ** ***************** ****.   .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

52407 : 88538

Bacillus_phage(40.0%)

protease,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047034909.1\|52407_53256_+	SDR family oxidoreductase	W8CYX9	Bacillus_phage	1.8e-08	44.2
WP_047034911.1\|54256_54466_+	hypothetical protein	NA	NA	NA	NA
WP_047034913.1\|54519_55908_-	MFS transporter	NA	NA	NA	NA
WP_047034914.1\|56113_56632_+\|transposase	transposase	A0A1B1P776	Bacillus_phage	5.1e-14	35.0
WP_143453937.1\|56664_57285_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	3.7e-19	33.5
WP_143453938.1\|57316_57496_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	7.3e-05	47.2
WP_047034916.1\|57619_58087_-\|transposase	IS200/IS605 family transposase	W0UUZ0	Sulfolobus_monocaudavirus	1.7e-16	38.0
WP_047034918.1\|58922_60305_+	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	2.4e-26	25.7
WP_047034920.1\|60613_61936_+	MATE family efflux transporter	NA	NA	NA	NA
WP_047034921.1\|61984_63466_-	ABC-F type ribosomal protection protein	A0A2I4R674	Erysipelothrix_phage	9.7e-34	27.4
WP_003705092.1\|63831_64416_+	peptidylprolyl isomerase	A0A076FI46	Aureococcus_anophage	7.7e-27	44.1
WP_047034923.1\|64566_65286_+	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	NA	NA	NA	NA
WP_047034925.1\|65341_66700_-	glutamate--cysteine ligase	NA	NA	NA	NA
WP_003703180.1\|66902_67133_+	hypothetical protein	NA	NA	NA	NA
WP_047034926.1\|67258_69367_+\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	2.3e-121	39.0
WP_047034928.1\|69578_70058_+	universal stress protein	NA	NA	NA	NA
WP_047034929.1\|70118_70295_-	hypothetical protein	NA	NA	NA	NA
WP_047034931.1\|70397_71855_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_003701500.1\|72094_73129_-	branched-chain amino acid aminotransferase	NA	NA	NA	NA
WP_003700709.1\|78948_79941_-	LacI family DNA-binding transcriptional regulator	C6ZCU4	Enterobacteria_phage	1.2e-19	26.3
WP_047034933.1\|79959_81450_-	sucrose-6-phosphate hydrolase	NA	NA	NA	NA
WP_003700711.1\|81852_83787_+	PTS beta-glucoside transporter subunit IIBCA	NA	NA	NA	NA
WP_047034935.1\|83901_85647_+	alpha amylase N-terminal ig-like domain-containing protein	NA	NA	NA	NA
WP_003700713.1\|85761_87150_+	potassium transporter KtrB	NA	NA	NA	NA
WP_003700714.1\|87169_87808_+	TrkA family potassium uptake protein	NA	NA	NA	NA
WP_047034938.1\|87884_88538_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_2

278721 : 365702

Lactobacillus_phage(34.21%)

integrase,portal,plate,capsid,terminase,tail,holin,transposase,protease,tRNA,head

attL 288511:288532|attR 331716:331737

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047035099.1\|278721_280749_+\|tRNA	methionine--tRNA ligase	A0A1V0SHR2	Klosneuvirus	1.4e-99	38.4
WP_011475600.1\|280882_281653_+	TatD family hydrolase	NA	NA	NA	NA
WP_080951842.1\|281663_282221_+	ribonuclease M5	NA	NA	NA	NA
WP_047035101.1\|282232_283123_+	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	NA	NA	NA	NA
WP_003702215.1\|283210_283444_+	Veg family protein	NA	NA	NA	NA
WP_047036064.1\|284400_285519_+	aminotransferase	NA	NA	NA	NA
WP_003702207.1\|285562_286033_+	arginine repressor	NA	NA	NA	NA
WP_047035103.1\|286071_286941_-	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	NA	NA	NA	NA
WP_003704861.1\|287156_288464_+	ammonium transporter	H8ZJB2	Ostreococcus_tauri_virus	5.2e-39	33.3
288511:288532	attL	NA	NA	NA	NA
WP_047035104.1\|288675_289821_-\|integrase	site-specific integrase	S6C485	Thermus_phage	1.5e-45	30.0
WP_080951800.1\|290129_291098_-	DUF3644 domain-containing protein	A0A0N9RUA4	Staphylococcus_phage	5.8e-88	51.5
WP_047035107.1\|291350_291677_-	hypothetical protein	NA	NA	NA	NA
WP_035165832.1\|292331_292796_+	hypothetical protein	NA	NA	NA	NA
WP_047035113.1\|293050_293992_-	3'-5' exoribonuclease	A0A1S5SFA9	Streptococcus_phage	5.7e-48	37.8
WP_047035114.1\|293994_294324_-	hypothetical protein	NA	NA	NA	NA
WP_052757118.1\|294346_294772_-	ImmA/IrrE family metallo-endopeptidase	A0A2P1JU12	Anoxybacillus_phage	1.6e-10	31.8
WP_047035115.1\|294783_295179_-	helix-turn-helix transcriptional regulator	A0A0M4QX29	Bacillus_phage	6.2e-20	41.5
WP_047035116.1\|295419_295608_+	helix-turn-helix transcriptional regulator	D2IZW2	Enterococcus_phage	2.0e-05	50.0
WP_052757119.1\|295611_296316_+	Rha family transcriptional regulator	A0A2P0ZL44	Lactobacillus_phage	1.7e-33	41.7
WP_155400834.1\|296339_296501_+	hypothetical protein	NA	NA	NA	NA
WP_047035117.1\|296478_296859_-	DUF2513 domain-containing protein	D2KRD9	Lactobacillus_phage	8.8e-32	55.6
WP_003703566.1\|297090_297357_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_047035119.1\|297593_297773_+	hypothetical protein	NA	NA	NA	NA
WP_052757120.1\|297811_298483_-	hypothetical protein	NA	NA	NA	NA
WP_047035120.1\|298611_298803_+	helix-turn-helix transcriptional regulator	A0A1X9I6I3	Streptococcus_phage	5.2e-09	50.8
WP_147655604.1\|298929_299094_+	hydrogenase maturation nickel metallochaperone HypA	NA	NA	NA	NA
WP_047035122.1\|299110_299332_+	hypothetical protein	NA	NA	NA	NA
WP_047035125.1\|299331_299811_+	siphovirus Gp157 family protein	A0A0A1EL06	Lactobacillus_phage	3.9e-37	49.1
WP_047035127.1\|299810_301178_+	DEAD/DEAH box helicase family protein	A0A0A1ENT0	Lactobacillus_phage	2.8e-176	67.5
WP_047035130.1\|301174_301957_+	AAA family ATPase	A0A0A1ENB5	Lactobacillus_phage	5.2e-87	67.2
WP_047035131.1\|301956_302460_+	DUF669 domain-containing protein	A0A0A1ELK1	Lactobacillus_phage	4.7e-41	48.5
WP_047035132.1\|302525_303305_+	bifunctional DNA primase/polymerase	A0A0A1ERC1	Lactobacillus_phage	2.5e-89	63.3
WP_047035133.1\|303307_304564_+	helicase	A0A0A1EL11	Lactobacillus_phage	1.5e-144	61.8
WP_047035134.1\|304847_305162_+	VRR-NUC domain-containing protein	A0A1B0YA93	Lactobacillus_phage	1.9e-32	64.1
WP_047035136.1\|305224_305416_+	hypothetical protein	NA	NA	NA	NA
WP_147655606.1\|305532_305907_+	hypothetical protein	NA	NA	NA	NA
WP_047035139.1\|305896_306130_+	hypothetical protein	NA	NA	NA	NA
WP_047035141.1\|306144_306375_+	hypothetical protein	NA	NA	NA	NA
WP_047035144.1\|306386_306545_+	hypothetical protein	NA	NA	NA	NA
WP_047035146.1\|306557_306860_+	hypothetical protein	NA	NA	NA	NA
WP_047035149.1\|306877_307075_+	hypothetical protein	NA	NA	NA	NA
WP_047035152.1\|307582_307771_+	hypothetical protein	NA	NA	NA	NA
WP_047035155.1\|307773_308016_+	hypothetical protein	NA	NA	NA	NA
WP_047035156.1\|308080_308368_+	hypothetical protein	NA	NA	NA	NA
WP_047035158.1\|308380_308698_+	hypothetical protein	NA	NA	NA	NA
WP_052757121.1\|309322_309742_+	hypothetical protein	NA	NA	NA	NA
WP_047035159.1\|310024_310234_+	hypothetical protein	NA	NA	NA	NA
WP_047035162.1\|310235_310562_+	HNH endonuclease	A0A2K9VBV6	Staphylococcus_phage	1.1e-17	52.2
WP_047035164.1\|310687_311140_+\|terminase	phage terminase small subunit P27 family	A6M947	Geobacillus_virus	1.7e-18	37.0
WP_080951802.1\|311129_312896_+\|terminase	terminase large subunit	F8J1B1	Lactobacillus_phage	1.7e-202	59.3
WP_047035168.1\|312908_314153_+\|portal	phage portal protein	A0A0K2CZB0	Paenibacillus_phage	2.9e-100	47.0
WP_047036069.1\|314133_314838_+\|protease	Clp protease ClpP	A0A0K2CZ28	Paenibacillus_phage	1.2e-71	58.1
WP_047035169.1\|314834_315962_+\|capsid	phage major capsid protein	A0A0K2CZ99	Paenibacillus_phage	2.0e-84	46.4
WP_052757122.1\|316180_316501_+\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_047035172.1\|316490_316835_+\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_047035174.1\|316846_317269_+	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_047035176.1\|317265_317637_+	hypothetical protein	NA	NA	NA	NA
WP_047035177.1\|317648_318296_+\|tail	tail protein	A0A060AKE9	Staphylococcus_phage	1.8e-13	30.2
WP_047035179.1\|318295_318685_+	hypothetical protein	NA	NA	NA	NA
WP_047035183.1\|323213_324029_+\|tail	phage tail family protein	E9LUJ3	Lactobacillus_phage	7.9e-46	41.2
WP_047035185.1\|324028_325879_+\|tail	phage tail protein	E9LUJ4	Lactobacillus_phage	1.1e-98	32.7
WP_047035186.1\|325882_326641_+\|holin	holin	Q5ULM6	Lactobacillus_virus	1.8e-15	28.1
WP_003702550.1\|326792_327071_+	hypothetical protein	NA	NA	NA	NA
WP_047035188.1\|327070_328147_+\|plate	BppU family phage baseplate upper protein	O03968	Lactobacillus_phage	1.2e-49	44.5
WP_011475666.1\|328227_328650_+	hypothetical protein	NA	NA	NA	NA
WP_047035190.1\|328663_329068_+	hypothetical protein	NA	NA	NA	NA
WP_011475668.1\|329069_329252_+	XkdX family protein	NA	NA	NA	NA
WP_047035192.1\|329306_329612_+	hypothetical protein	NA	NA	NA	NA
WP_003704600.1\|329608_329935_+	hypothetical protein	NA	NA	NA	NA
WP_047035194.1\|329946_331215_+	LysM peptidoglycan-binding domain-containing protein	Q6EVN0	Oenoccocus_phage	2.0e-120	55.9
WP_047035195.1\|331720_333103_-	argininosuccinate lyase	NA	NA	NA	NA
331716:331737	attR	NA	NA	NA	NA
WP_003709272.1\|333126_334338_-	argininosuccinate synthase	NA	NA	NA	NA
WP_047035197.1\|334899_336075_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_047035198.1\|336090_337080_+	D-2-hydroxyacid dehydrogenase	Q89388	Paramecium_bursaria_Chlorella_virus	8.1e-45	36.0
WP_047035200.1\|337098_338148_+	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_003699652.1\|338421_339513_-	aspartate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_047035202.1\|339742_340150_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_003709294.1\|340326_341166_+	pur operon repressor	NA	NA	NA	NA
WP_047035205.1\|341296_342514_+	MFS transporter	NA	NA	NA	NA
WP_011475681.1\|342656_344066_+	bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU	A0A0N7G7P8	Chrysochromulina_ericina_virus	1.6e-25	30.6
WP_003699646.1\|344156_345134_+	ribose-phosphate diphosphokinase	A0A2K9L8D8	Tupanvirus	1.5e-43	37.0
WP_047035208.1\|345206_345707_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_047035210.1\|345880_346720_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	8.2e-46	39.1
WP_003699642.1\|346725_346962_-	hypothetical protein	NA	NA	NA	NA
WP_047035211.1\|347104_347875_+	nucleoside phosphorylase	F5CA76	Streptococcus_phi-m46.1-like_phage	1.8e-36	46.3
WP_003702586.1\|347949_349572_+	ATP-binding cassette domain-containing protein	A0A1V0SKJ1	Klosneuvirus	1.0e-52	27.7
WP_047035213.1\|349646_350315_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_011475686.1\|350364_351330_-	biotin--[acetyl-CoA-carboxylase] ligase	NA	NA	NA	NA
WP_047035215.1\|351458_352559_+	YibE/F family protein	NA	NA	NA	NA
WP_014568166.1\|352555_353305_+	YibE/F family protein	NA	NA	NA	NA
WP_047035217.1\|353524_354550_+	hypothetical protein	NA	NA	NA	NA
WP_047035219.1\|354549_356157_+	AAA family ATPase	G3MAX6	Bacillus_virus	5.8e-32	33.5
WP_047035221.1\|356160_357456_+	hypothetical protein	NA	NA	NA	NA
WP_047035223.1\|357448_359461_+	ATP-dependent helicase	NA	NA	NA	NA
WP_047035224.1\|359453_362069_+	hypothetical protein	NA	NA	NA	NA
WP_047035226.1\|362122_363214_+	DUF4767 domain-containing protein	NA	NA	NA	NA
WP_047035227.1\|363231_363948_+	hypothetical protein	NA	NA	NA	NA
WP_047035229.1\|364175_365702_-\|transposase	IS66 family transposase	S5VTD3	Leptospira_phage	1.6e-39	28.5

DBSCAN-SWA_3

699603 : 708375

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003702184.1\|699603_700086_+	pantetheine-phosphate adenylyltransferase	A0A1B1IVQ3	uncultured_Mediterranean_phage	1.2e-22	37.9
WP_003702195.1\|700082_701117_+	PDZ domain-containing protein	NA	NA	NA	NA
WP_014568323.1\|701428_702142_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	6.3e-39	37.8
WP_003703354.1\|702160_702409_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_003700039.1\|702408_703083_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_047035516.1\|703084_705310_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.9e-144	39.8
WP_003707943.1\|705285_706737_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.5e-63	35.6
WP_003700044.1\|706737_707775_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	2.0e-62	42.3
WP_003700046.1\|707787_708375_+	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	1.1e-25	36.9

DBSCAN-SWA_4

964534 : 971409

Streptococcus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047035716.1\|964534_965731_-	aminotransferase class V-fold PLP-dependent enzyme	A0A2K9L0G1	Tupanvirus	4.6e-26	32.6
WP_047035718.1\|965727_967617_-	polysaccharide biosynthesis protein	L7Y3T9	Megavirus	5.0e-27	33.0
WP_003704149.1\|967637_968300_-	CpsD/CapB family tyrosine-protein kinase	A0A1X9I5D6	Streptococcus_phage	1.1e-37	38.9
WP_047035719.1\|968304_969048_-	chain-length determining protein	A0A1X9I5E1	Streptococcus_phage	5.4e-25	33.6
WP_047034952.1\|969274_969463_+	hypothetical protein	NA	NA	NA	NA
WP_047034953.1\|969452_969809_+	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	2.8e-16	40.4
WP_080951820.1\|970062_971409_+\|transposase	IS66 family transposase	S5VTD3	Leptospira_phage	1.7e-37	28.4

DBSCAN-SWA_5

1160962 : 1171002

Streptococcus_phage(28.57%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003700621.1\|1160962_1161556_+	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	1.5e-54	54.8
WP_003700622.1\|1161605_1162553_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	1.9e-51	39.4
WP_003710476.1\|1162575_1163589_-	YvcK family protein	A1IMD5	Streptococcus_phage	2.9e-98	56.3
WP_003700624.1\|1163585_1164503_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	7.9e-10	34.5
WP_047035087.1\|1164686_1166213_-\|transposase	IS66 family transposase	S5VTD3	Leptospira_phage	2.7e-39	28.5
WP_047034953.1\|1166287_1166644_-	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	2.8e-16	40.4
WP_047034952.1\|1166633_1166822_-	hypothetical protein	NA	NA	NA	NA
WP_014568558.1\|1166956_1167598_-	NAD(P)H-binding protein	NA	NA	NA	NA
WP_003700626.1\|1167621_1168092_-	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_047035789.1\|1168167_1171002_-	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	7.4e-309	56.6

DBSCAN-SWA_6

1191976 : 1202507

Leptospira_phage(33.33%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047035797.1\|1191976_1194379_-	cation-translocating P-type ATPase	M1IAU8	Acanthocystis_turfacea_Chlorella_virus	4.6e-41	27.0
WP_047035229.1\|1194601_1196128_-\|transposase	IS66 family transposase	S5VTD3	Leptospira_phage	1.6e-39	28.5
WP_047034953.1\|1196202_1196559_-	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	2.8e-16	40.4
WP_047034952.1\|1196548_1196737_-	hypothetical protein	NA	NA	NA	NA
WP_047035798.1\|1196877_1198500_-	chaperonin GroEL	A0A219YK78	uncultured_virus	2.8e-159	56.2
WP_003706535.1\|1198529_1198814_-	co-chaperone GroES	A0A221S422	uncultured_virus	7.3e-15	47.8
WP_047035799.1\|1199009_1199639_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_047035800.1\|1199742_1200384_-	redox-sensing transcriptional repressor Rex	NA	NA	NA	NA
WP_047035801.1\|1200557_1202507_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L0W2	Tupanvirus	2.2e-49	29.3

DBSCAN-SWA_7

1208055 : 1217075

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047035804.1\|1208055_1209048_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	2.6e-35	30.9
WP_003700663.1\|1209082_1209709_-	dTMP kinase	M1PSC7	Streptococcus_phage	6.9e-50	51.0
WP_011476227.1\|1209828_1210068_-	YaaL family protein	NA	NA	NA	NA
WP_003700665.1\|1210081_1210681_-	recombination protein RecR	NA	NA	NA	NA
WP_080550229.1\|1210707_1211022_-	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_047035805.1\|1211039_1212779_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	8.7e-58	38.6
WP_044005603.1\|1212984_1213452_-	nucleoside deaminase	NA	NA	NA	NA
WP_047035806.1\|1213498_1214110_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_003703366.1\|1214312_1214543_+	glutaredoxin-like protein NrdH	X2KRY7	Enterococcus_phage	6.1e-12	40.3
WP_003700671.1\|1214539_1214923_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	R4JF54	Bacillus_phage	5.8e-15	38.7
WP_047035807.1\|1214903_1217075_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	2.9e-260	62.8

DBSCAN-SWA_8

1459658 : 1463711

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047035902.1\|1459658_1460417_-	3-oxoacyl-ACP reductase	Q06VL0	Trichoplusia_ni_ascovirus	9.1e-12	29.8
WP_041822915.1\|1460416_1460644_-	DUF2829 domain-containing protein	A8AT88	Listeria_phage	1.9e-05	35.6
WP_003701672.1\|1460657_1461155_-	QueT transporter family protein	E7DN70	Pneumococcus_phage	1.3e-14	36.7
WP_003701682.1\|1461655_1462528_-	DegV family protein	NA	NA	NA	NA
WP_003701687.1\|1462599_1462944_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	2.1e-08	37.1
WP_035150261.1\|1462940_1463330_-	CrcB family protein	A0A2H4PQR0	Staphylococcus_phage	5.5e-05	33.3
WP_003705375.1\|1463387_1463711_-	thioredoxin	A0A1X9I9P5	Staphylococcus_phage	2.5e-19	39.4

DBSCAN-SWA_9

1541796 : 1549185

Escherichia_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_052757128.1\|1541796_1543341_-	glucosaminidase domain-containing protein	A0A0K2CP65	Brevibacillus_phage	2.3e-17	38.9
WP_080951852.1\|1543368_1544907_-	peptidoglycan DD-metalloendopeptidase family protein	Q6SEC2	Lactobacillus_prophage	7.7e-42	60.7
WP_047035942.1\|1545183_1545636_+	hypothetical protein	NA	NA	NA	NA
WP_047035943.1\|1545793_1546633_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	2.8e-38	39.9
WP_047035944.1\|1546688_1547720_-	dTDP-glucose 4,6-dehydratase	H9NC62	Sphingomonas_phage	3.0e-50	35.7
WP_003701105.1\|1547731_1548313_-	dTDP-4-dehydrorhamnose 3,5-epimerase	A0A218MN57	uncultured_virus	3.0e-31	43.5
WP_003702305.1\|1548315_1549185_-	glucose-1-phosphate thymidylyltransferase RfbA	K7QKA7	Escherichia_phage	1.2e-105	63.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP011404

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

27860 : 45270

Bacillus_phage(33.33%)

integrase,transposase

attL 24331:24346|attR 48584:48599

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
24331:24346	attL	NA	NA	NA	NA
WP_147655624.1\|27860_28754_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.9e-40	38.0
WP_047036129.1\|28750_29269_-\|transposase	transposase	A0A1B1P776	Bacillus_phage	7.8e-15	36.5
WP_047036130.1\|29951_30905_+	hypothetical protein	NA	NA	NA	NA
WP_003699254.1\|30971_31247_-	HU family DNA-binding protein	A0A0H3UZA0	Geobacillus_virus	4.1e-23	62.9
WP_047036131.1\|31550_36140_+	S8 family serine peptidase	A0A1B0T6A2	Bacillus_phage	3.0e-17	31.5
WP_014573588.1\|36289_36985_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_011475896.1\|37142_37574_-\|transposase	IS200/IS605 family transposase	A0A0P0IQC6	Lactobacillus_phage	4.6e-29	47.2
WP_011475897.1\|37673_38951_+\|transposase	transposase	A0A286QQE5	Streptococcus_phage	4.3e-54	35.4
WP_047036132.1\|39291_39864_+	DNA starvation/stationary phase protection protein	A0A0A7RTZ1	Clostridium_phage	1.1e-22	42.6
WP_080951855.1\|40008_40713_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_147655626.1\|40916_41324_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A0C5AEA5	Paenibacillus_phage	2.1e-31	50.7
WP_003703288.1\|42292_42526_+	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_047036136.1\|42844_44749_+	heavy metal translocating P-type ATPase	E4ZFI9	Streptococcus_phage	7.2e-98	34.7
WP_047036137.1\|44988_45270_+\|transposase	transposase	NA	NA	NA	NA
48584:48599	attR	NA	NA	NA	NA

DBSCAN-SWA_2

85476 : 142959

Catovirus(13.33%)

integrase,transposase

attL 91697:91712|attR 121661:121676

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047036162.1\|85476_88602_-	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	8.2e-67	25.6
WP_147655630.1\|88696_89800_-	restriction endonuclease subunit S	A0A1V0S9X4	Catovirus	6.4e-14	32.2
WP_047036163.1\|89796_90765_-\|integrase	tyrosine-type recombinase/integrase	A0A2H4JAA2	uncultured_Caudovirales_phage	7.0e-33	31.1
WP_047036164.1\|90895_91504_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_047036165.1\|91508_92042_-	restriction endonuclease subunit S	A0A1V0S9X7	Catovirus	1.1e-11	33.1
91697:91712	attL	NA	NA	NA	NA
WP_047036166.1\|92031_93552_-	SAM-dependent DNA methyltransferase	A0A2H4PQP4	Staphylococcus_phage	2.5e-53	29.8
WP_047036167.1\|93732_95148_-	N-6 DNA methylase	A0A1X9I6H1	Streptococcus_phage	6.0e-25	24.7
WP_047036168.1\|95140_95707_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_047036169.1\|95900_96950_-	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_014573620.1\|97152_98148_+	D-2-hydroxyacid dehydrogenase	M1H502	Paramecium_bursaria_Chlorella_virus	1.8e-44	38.1
WP_047036170.1\|98208_98889_-	fructose-6-phosphate aldolase	A0A0E3EPH4	Synechococcus_phage	8.7e-22	31.3
WP_003699445.1\|98955_99336_-	PTS glucitol/sorbitol transporter subunit IIA	NA	NA	NA	NA
WP_047036171.1\|99591_100989_-\|transposase	transposase	NA	NA	NA	NA
WP_080951857.1\|101054_101492_+\|transposase	IS200/IS605 family transposase	A0A0P0IQC6	Lactobacillus_phage	1.1e-41	62.0
WP_047036173.1\|101767_102970_+	MFS transporter	NA	NA	NA	NA
WP_047036174.1\|103042_103942_-	nitronate monooxygenase	NA	NA	NA	NA
WP_047036175.1\|104046_106704_-	bifunctional acetaldehyde-CoA/alcohol dehydrogenase	NA	NA	NA	NA
WP_047036176.1\|107547_113247_+	MucBP domain-containing protein	NA	NA	NA	NA
WP_047036177.1\|113353_115324_-	fructose-1,6-bisphosphatase	NA	NA	NA	NA
WP_047036178.1\|115674_116496_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_047036180.1\|116531_116798_+	hypothetical protein	NA	NA	NA	NA
WP_187115525.1\|116905_117748_-	hypothetical protein	NA	NA	NA	NA
WP_047036236.1\|118017_118665_-	HAD family phosphatase	M1H9H9	Acanthocystis_turfacea_Chlorella_virus	2.1e-09	27.1
WP_003710792.1\|118778_119120_-	hypothetical protein	NA	NA	NA	NA
WP_047036182.1\|119572_120751_-	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_047036183.1\|120768_121554_-	carbon-nitrogen family hydrolase	NA	NA	NA	NA
WP_003708605.1\|121668_122160_-	DUF1440 domain-containing protein	NA	NA	NA	NA
121661:121676	attR	NA	NA	NA	NA
WP_003703477.1\|122186_122501_-	metal-sulfur cluster assembly factor	NA	NA	NA	NA
WP_003708609.1\|122517_123399_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha	NA	NA	NA	NA
WP_047036184.1\|123411_124074_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit beta	NA	NA	NA	NA
WP_047036185.1\|124331_124799_-\|transposase	IS200/IS605 family transposase	W0UUZ0	Sulfolobus_monocaudavirus	6.8e-18	38.8
WP_047036186.1\|125013_126519_-	sodium:solute symporter	NA	NA	NA	NA
WP_047036187.1\|126536_127718_-	cation:proton antiporter	NA	NA	NA	NA
WP_047036189.1\|127727_128459_-	sugar phosphate isomerase/epimerase	NA	NA	NA	NA
WP_003699392.1\|128754_129192_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	3.9e-23	40.7
WP_047036190.1\|129276_130140_-	ROK family protein	NA	NA	NA	NA
WP_172399972.1\|130370_131246_+	N-acetylneuraminate lyase	NA	NA	NA	NA
WP_014573640.1\|131266_131956_+	N-acetylmannosamine-6-phosphate 2-epimerase	NA	NA	NA	NA
WP_047036192.1\|132001_132826_+	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_047036193.1\|132877_133495_+	NAD-dependent epimerase/dehydratase family protein	NA	NA	NA	NA
WP_047036194.1\|133667_135155_+	glutamate/gamma-aminobutyrate family transporter YjeM	NA	NA	NA	NA
WP_003699379.1\|135208_135316_-	putative metal homeostasis protein	NA	NA	NA	NA
WP_011476677.1\|135335_135605_-	30S ribosomal protein S14	NA	NA	NA	NA
WP_052757141.1\|135791_137726_+	TetM/TetW/TetO/TetS family tetracycline resistance ribosomal protection protein	E4ZFJ7	Streptococcus_phage	6.2e-65	29.3
WP_147655638.1\|139259_139481_+\|transposase	transposase	NA	NA	NA	NA
WP_047036196.1\|141540_142050_+\|transposase	transposase	A0A1B1P776	Bacillus_phage	7.7e-15	36.5
WP_191979250.1\|142091_142802_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.4e-30	36.9
WP_160944225.1\|142776_142959_+\|transposase	IS3 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP011405

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP011403

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP011404

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection