CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP026067	Staphylococcus aureus strain FDAARGOS_21 chromosome, complete genome	7 crisprs	cas3,DEDDh,DinG,csa3,WYL	3	3	11	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP026067_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP026067_1

163674-163765

Orphan

Consensus_repeat	Method
TGCGTTCCTTTATTTTCTGCGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP026067_1

>merge|NZ_CP026067|1|163674-163765|CRISPRCasFinder
TGCGTTCCTTTATTTTCTGCGAATTTTATGAGCTAGAAAGGCTTATGCAGTTGACGTTTTACGTCCAACTGCGTTCCTTTATTTTCTGCGAA

>NZ_CP026067|1|1|163674-163765|CRISPRCasFinder
TGCGTTCCTTTATTTTCTGCGAA	TTTTATGAGCTAGAAAGGCTTATGCAGTTGACGTTTTACGTCCAAC
TGCGTTCCTTTATTTTCTGCGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP026067.1\|WP_031927725.1\|172734_174093_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
NZ_CP026067.1\|WP_000783428.1\|168422_169400_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	unknown	unknown	gnl\|CDD\|273388
NZ_CP026067.1\|WP_047212943.1\|167473_168421_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	unknown	unknown	gnl\|CDD\|369625
NZ_CP026067.1\|WP_000971544.1\|170632_171748_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223234
NZ_CP026067.1\|WP_001046645.1\|171725_172733_-\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|235755
NZ_CP026067.1\|WP_000479576.1\|158128_158848_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP026067.1\|WP_031927724.1\|169929_170622_-\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|224342
NZ_CP026067.1\|WP_000825931.1\|158828_159608_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270429
NZ_CP026067.1\|WP_000762708.1\|161341_161446_+\|putative-metal-homeostasis-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_047212940.1\|162612_163479_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP026067.1\|WP_000792566.1\|164175_165486_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|288473
NZ_CP026067.1\|WP_000200954.1\|169451_169919_-\|QueT-transporter-family-protein	unknown	unknown	gnl\|CDD\|377623
NZ_CP026067.1\|WP_000038972.1\|159728_161168_-\|multidrug-efflux-MFS-transporter-MdeA	unknown	unknown	gnl\|CDD\|129794
NZ_CP026067.1\|WP_000615459.1\|157400_158132_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP026067.1\|WP_001012216.1\|156053_157304_+\|FemA/FemB-family-glycyltransferase-FmhA	unknown	unknown	gnl\|CDD\|367067
NZ_CP026067.1\|WP_001807148.1\|163961_164081_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_000594519.1\|165975_166905_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	unknown	unknown	gnl\|CDD\|369625
NZ_CP026067.1\|WP_000819846.1\|155436_155799_-\|DUF4467-domain-containing-protein	unknown	unknown	gnl\|CDD\|291399
NZ_CP026067.1\|WP_001125208.1\|161599_162286_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184518
NZ_CP026067.1\|WP_000162805.1\|154818_155418_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|224565

Protein	Function_ID	Function_description	E-value
NZ_CP026067.1\|WP_031927725.1\|172734_174093_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
NZ_CP026067.1\|WP_000783428.1\|168422_169400_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	5.50766e-128
NZ_CP026067.1\|WP_047212943.1\|167473_168421_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	4.1102e-93
NZ_CP026067.1\|WP_000971544.1\|170632_171748_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	9.08937e-138
NZ_CP026067.1\|WP_001046645.1\|171725_172733_-\|biotin-synthase-BioB	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
NZ_CP026067.1\|WP_000038972.1\|159728_161168_-\|multidrug-efflux-MFS-transporter-MdeA	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.56422e-92
NZ_CP026067.1\|WP_031927724.1\|169929_170622_-\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|224342	COG1424, BioW, Pimeloyl-CoA synthetase [Coenzyme metabolism].	2.10153e-129
NZ_CP026067.1\|WP_000825931.1\|158828_159608_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.35689e-100
NZ_CP026067.1\|WP_047212940.1\|162612_163479_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	7.66469e-90
NZ_CP026067.1\|WP_000792566.1\|164175_165486_+\|hypothetical-protein	gnl\|CDD\|288473	pfam11621, Sbi-IV, C3 binding domain 4 of IgG-bind protein SBI. This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.	1.01337e-26
NZ_CP026067.1\|WP_000200954.1\|169451_169919_-\|QueT-transporter-family-protein	gnl\|CDD\|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	0.00118414
NZ_CP026067.1\|WP_000479576.1\|158128_158848_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.98247e-78
NZ_CP026067.1\|WP_000615459.1\|157400_158132_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.20318e-144
NZ_CP026067.1\|WP_001012216.1\|156053_157304_+\|FemA/FemB-family-glycyltransferase-FmhA	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	0
NZ_CP026067.1\|WP_000594519.1\|165975_166905_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	4.31899e-97
NZ_CP026067.1\|WP_000819846.1\|155436_155799_-\|DUF4467-domain-containing-protein	gnl\|CDD\|291399	pfam14729, DUF4467, Domain of unknown function with cystatin-like fold (DUF4467). Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan.	3.44071e-31
NZ_CP026067.1\|WP_001125208.1\|161599_162286_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184518	PRK14119, gpmA, phosphoglyceromutase; Provisional.	3.52864e-167
NZ_CP026067.1\|WP_000162805.1\|154818_155418_-\|DsbA-family-protein	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	6.8825e-31

>NZ_CP026067.1|WP_047212940.1|162612_163479_-|cation-transporter
MSHNENLKLAQRGAYLSLIVYIILSIVKYVTGFVFNSAAVRADALNNMTDIIVSLAVIIGLKISIKPADRNHPYGHLKSENISSLLVSFVIMFVGIQVVIQNALRLFKEDDVVPNAITIIVSLISGLVMLIVFAVNQRLAKRTKSSSLNSAAKDNLSDSLVSIGTAIGLIFTQIGFPIVDIILATLLGLLIVYTGFGIFKEAIFMLSDGFNETELEAYRNDILEVDEVQEVKSIKGRYHGSSVFIDVTIVVDANLSLVEAHQICDNVEHHLHKKGISSVYVHPEPDHL
>NZ_CP026067.1|WP_001125208.1|161599_162286_-|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase
MPKLILCRHGQSEWNAKNLFTGWEDVNLSEQGINEATRAGEKVRENNIAIDVAFTSLLTRALDTTHYILTESKQQWIPVYKSWRLNERHYGGLQGLNKDDARKEFGEEQVHIWRRSYDVKPPAETEEQREAYLADRRYNHLDKRMMPYSESLKDTLVRVIPFWTDHISQYLLDGQTVLVSAHGNSIRALIKYLEDVSDEDIINYEIKTGAPLVYELTDDLEVIDKYYL
>NZ_CP026067.1|WP_000762708.1|161341_161446_+|putative-metal-homeostasis-protein
MKLDLQTARRNLNSPNIKTRKRALKIIKQHKRAK
>NZ_CP026067.1|WP_000038972.1|159728_161168_-|multidrug-efflux-MFS-transporter-MdeA
MSKKQKLTMIITMLMGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVIPLSALVIQRYTTRQVFLVGITIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTTILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGFKTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGIALVALFVLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGLTLLPGAIVMAFMSMTSGALYEKFGPRKLALVGMAIVVITTAYFVVMDEQTSTIMLATVYAIRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFSPTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
>NZ_CP026067.1|WP_000825931.1|158828_159608_-|transporter-substrate-binding-domain-containing-protein
MKRLLFVMIAFVFILAACGNNSSKDKEASKDSKTINVGTEGTYAPFSFHDKDGKLTGYDIDVIKAVAKEEGLKLKFNETSWDSMFAGLDAGRFDVIANQVGINPDREKKYKFSKPYTFSSAVLVIRENEKDIKDFDDVKGKKLAQTFTSNYGKLAKDKGADITKVDGFNQSMDLLLSKRVDGTFNDSLSYLDYKKQKPNAKIKAIKGNAEQSRSAFAFSKKVDDETVQKFNDGLKKIEENGELAKIGKKWFGQDVSKSK
>NZ_CP026067.1|WP_000479576.1|158128_158848_-|amino-acid-ABC-transporter-permease
MFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKILRSISRVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQAIRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIISIIQGIYESYIERGYRS
>NZ_CP026067.1|WP_000615459.1|157400_158132_-|amino-acid-ABC-transporter-ATP-binding-protein
MIQLNNIHKSFNDVEVIKGIDLSVEQGEVVTLIGRSGSGKTTLLRMINALEIPTEGTVYVNGKTYTSKDKKSQIEVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKLKKDEARGKSLELLEKVGLTHVKDQRPHALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLKVIKDLANEGMTMVIVTHEMRFAKEVSNNIVFIHEGMIGEQGAPEEMFNRPKTEELKRFLNVINEE
>NZ_CP026067.1|WP_001012216.1|156053_157304_+|FemA/FemB-family-glycyltransferase-FmhA
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHKVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKQNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDTLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLAYIDLNEYLKTLQLKQQQLTAELSGVEEALEESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDFSESSEDYGVQQFKKGFNAHVEEYIGDFIKPIKPLLYKVKTYLNHKRR
>NZ_CP026067.1|WP_000819846.1|155436_155799_-|DUF4467-domain-containing-protein
MKRFVATVLLLLVFISGCGNDKYVKEIDEAVKIQNQKQEQLAKKGNGDRVDHFERKDANIYVYDKDKIIILAYKPLSNDDEVHYYAYNFSDKRVSYKQDFDSRRYYQQHDADYHEENMTN
>NZ_CP026067.1|WP_000162805.1|154818_155418_-|DsbA-family-protein
MTKKLLTLFIVSMLILTACGKKESATTSSKNGKPLVVIYGDYKCPYCKELDEKVMPKLRKNYIDDHKVEYQFVNLAFLGKDSIVGSRASHAVLMYAPKSFLDFQKQLFAAQQDENKEWLTKELLDKHIKQLHLDKETENKIIKDYKTKDSKSWKAAEKDKKIAKDNHIKTTPTAFINGEKVEDPYDYESYEKLLKDKIK
>NZ_CP026067.1|WP_001807148.1|163961_164081_-|hypothetical-protein
MLTNRLTSVNYVKKRLIQNIQRILSKEVLYGEMQWFANK
>NZ_CP026067.1|WP_000792566.1|164175_165486_+|hypothetical-protein
MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVQKHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKAESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYTDKYFKYKGTIDKTVLSVFGNGYKSYIQPLKVEDQKNYVSKSYAQVRNYVTETLNTGKVLYAFYQNPKVVKAAITTAETASSIKNIFSSFTSFFK
>NZ_CP026067.1|WP_000594519.1|165975_166905_+|bi-component-gamma-hemolysin-HlgAB-subunit-A
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
>NZ_CP026067.1|WP_047212943.1|167473_168421_+|bi-component-gamma-hemolysin-HlgCB-subunit-C
MLRNKILATTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQTLGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPSFIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKYEVNWKTHEIKVKGQN
>NZ_CP026067.1|WP_000783428.1|168422_169400_+|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B
MKMNKLVKSSVATSMALLLLSGTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFVKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
>NZ_CP026067.1|WP_000200954.1|169451_169919_-|QueT-transporter-family-protein
MTSKDITQISVIAAILTILAVLKIPSIIPGLDFQLSAPAALLILAFFGIKKYFLGGLLSSVLLLIFGVFNPINVIISIIFRVIAIAVVYLLKINVLSLVLASVLGSLVSRLLLSIILNLPVWVVLLNAIPGVIFTLIVAIPLYLTLRKRMAVLLR
>NZ_CP026067.1|WP_031927724.1|169929_170622_-|6-carboxyhexanoate--CoA-ligase
MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKANLQKLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFASAKIGYHRLFDIKPVNTRYGGRIIFVDDRIDLHHYISFLESTPKQVVYETV
>NZ_CP026067.1|WP_000971544.1|170632_171748_-|pyridoxal-phosphate-dependent-aminotransferase-family-protein
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSSTAYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAEYPNQNIQKIIISDSVFSTNGDLVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSNDVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDVDRLFEILHQED
>NZ_CP026067.1|WP_001046645.1|171725_172733_-|biotin-synthase-BioB
MNLAKRILQGEQLTKETVLKIYEDTNIDTLDLLNEAYILRKHYFGKKVKLNMILNAKSGICPENCGYCGQSRDIKQKQRYALIPEEQIIDGAKVAHDNHIGTYCIVMSGRGPSDKEVDHISNTVRTIKSQHPQLKICACLGLTNDEQAKKLKSAGVDRYNHNINTSENYHDNVVTTHSYKDRTDTIELMKANNISPCSGVICGMGESNQDIVDMAFALKEMDADSIPINFLHPIKGTKFGSMDDLTPMKCLRIVALFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQPNQLDYDMINDLGFEIDYDTCENKENKNDVSRAN
>NZ_CP026067.1|WP_031927725.1|172734_174093_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MNYTQQLKQKDSEYVWHPFTQMGVYSKEEAIIIEKGKGSYLYDTNGNKYLDGYASLWVNVHGHNNKYLNKVIKKQLNKIAHSTLLGSSNIPSIELAEKLIEITPSNLRKVFYSDTGSASVEIAIKMAYQYWKNIDREKYAKKNKFITLNHGYHGDTIGAVSVGGIKTFHKIFKDLIFENIQVESPSFYRSNYDTENEMMTAILTNIEQILIERNDEIAGFILEPLIQGATGLFVHPKGFLKEVEKLCKKYDVLLICDEVAVGFGRTGKMFACNHEDVQPDIMCLGKAITGGYLPLAATLTSQKIYDAFLSDSHGVNTFFHGHTYTGNQIVCTVALENIRLYEKRNLLSHIETTSSTLEKQLHALKRHRNVGDVRGRGLMFGVELVTDKDSKTPLEIEKVERIVRNCKENGLMIRNLENVITFVPVLSMSNKEVKTMVRIFKKAVHNILDRKC

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Crispr_ID: NZ_CP026067_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP026067_2

453208-453286

Orphan

Consensus_repeat	Method
TTCTCTATGTTGGGGCCCCGCCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP026067_2

>merge|NZ_CP026067|2|453208-453286|CRISPRCasFinder
TTCTCTATGTTGGGGCCCCGCCAACTCGCATTGCCTGTAGAATTTCTTTTCGAAATTCTCTTTGTTGGGGCCCCGCCAA

>NZ_CP026067|2|2|453208-453286|CRISPRCasFinder
TTCTCTATGTTGGGGCCCCGCCAA	CTCGCATTGCCTGTAGAATTTCTTTTCGAAA
TTCTCTTTGTTGGGGCCCCGCCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP026067.1\|WP_000240580.1\|450779_451085_+\|intracellular-adhesion-protein-D	unknown	unknown	gnl\|CDD\|188447
NZ_CP026067.1\|WP_000653261.1\|448853_449414_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376089
NZ_CP026067.1\|WP_000944131.1\|462426_463041_-\|ATP-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|172153
NZ_CP026067.1\|WP_000185863.1\|446634_447327_-\|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl\|CDD\|349772
NZ_CP026067.1\|WP_000244266.1\|445135_445636_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
NZ_CP026067.1\|WP_000635617.1\|459032_459611_-\|imidazole-glycerol-phosphate-synthase-subunit-HisH	unknown	unknown	gnl\|CDD\|171871
NZ_CP026067.1\|WP_047213037.1\|456198_456411_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_000930656.1\|461183_462434_-\|histidinol-dehydrogenase	unknown	unknown	gnl\|CDD\|172308
NZ_CP026067.1\|WP_000877364.1\|451081_451954_+\|intercellular-adhesin-biosynthesis-polysaccharide-N-deacetylase	unknown	unknown	gnl\|CDD\|188448
NZ_CP026067.1\|WP_000592606.1\|457580_458339_-\|imidazole-glycerol-phosphate-synthase-subunit-HisF	unknown	unknown	gnl\|CDD\|234996
NZ_CP026067.1\|WP_000186284.1\|456951_457584_-\|bifunctional-phosphoribosyl-AMP-cyclohydrolase/phosphoribosyl-ATP-diphosphatase-HisIE	unknown	unknown	gnl\|CDD\|235067
NZ_CP026067.1\|WP_000571733.1\|458335_459040_-\|1-(5-phosphoribosyl)-5-((5--phosphoribosylamino)methylideneamino)imidazole-4--carboxamide-isomerase	unknown	unknown	gnl\|CDD\|172156
NZ_CP026067.1\|WP_000565312.1\|445870_446638_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|226870
NZ_CP026067.1\|WP_047213039.1\|460154_461168_-\|histidinol-phosphate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223157
NZ_CP026067.1\|WP_072358118.1\|453383_455426_-\|YSIRK-domain-containing-triacylglycerol-lipase-Lip1	unknown	unknown	gnl\|CDD\|224001
NZ_CP026067.1\|WP_000640270.1\|459607_460186_-\|imidazoleglycerol-phosphate-dehydratase-HisB	unknown	unknown	gnl\|CDD\|153419
NZ_CP026067.1\|WP_001159430.1\|449577_450816_+\|poly-beta-1,6-N-acetyl-D-glucosamine-synthase	unknown	unknown	gnl\|CDD\|274866
NZ_CP026067.1\|WP_000659677.1\|447343_448006_-\|capsular-polysaccharide-biosynthesis-protein-CapA	unknown	unknown	gnl\|CDD\|226453
NZ_CP026067.1\|WP_000723844.1\|451940_452993_+\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|226446
NZ_CP026067.1\|WP_000301937.1\|444656_445133_-\|peptide-methionine-(S)-S-oxide-reductase	unknown	unknown	gnl\|CDD\|235497

Protein	Function_ID	Function_description	E-value
NZ_CP026067.1\|WP_000240580.1\|450779_451085_+\|intracellular-adhesion-protein-D	gnl\|CDD\|188447	TIGR03932, IcaD_partial, intracellular adhesion protein D. Members of this protein family are IcaD (intracellular adhesion protein D), which with catalytic subunit IcaA forms an N-acetylglucosaminyltransferase. In the absence of IcaC, this enzyme forms N-acetylglucosamine oligomers up to 20 in length. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	3.14464e-30
NZ_CP026067.1\|WP_000653261.1\|448853_449414_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|376089	pfam18665, TetR_C_37, Tetracyclin repressor-like, C-terminal domain. IcaR belongs to the tetracycline repressor (TetR) family of proteins, which are involved in a wide variety of gene regulations. It binds to a 42 bp region immediately upstream of the icaA gene. This entry represents the C-terminal domain which is involved in dimerization.	2.88245e-28
NZ_CP026067.1\|WP_000944131.1\|462426_463041_-\|ATP-phosphoribosyltransferase	gnl\|CDD\|172153	PRK13584, hisG, ATP phosphoribosyltransferase.	2.8628e-131
NZ_CP026067.1\|WP_000185863.1\|446634_447327_-\|polysaccharide-biosynthesis-tyrosine-autokinase	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	2.83977e-84
NZ_CP026067.1\|WP_000244266.1\|445135_445636_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.58707e-14
NZ_CP026067.1\|WP_000635617.1\|459032_459611_-\|imidazole-glycerol-phosphate-synthase-subunit-HisH	gnl\|CDD\|171871	PRK13142, hisH, imidazole glycerol phosphate synthase subunit HisH; Provisional.	9.73797e-130
NZ_CP026067.1\|WP_000571733.1\|458335_459040_-\|1-(5-phosphoribosyl)-5-((5--phosphoribosylamino)methylideneamino)imidazole-4--carboxamide-isomerase	gnl\|CDD\|172156	PRK13587, PRK13587, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Provisional.	6.30354e-168
NZ_CP026067.1\|WP_000930656.1\|461183_462434_-\|histidinol-dehydrogenase	gnl\|CDD\|172308	PRK13770, PRK13770, histidinol dehydrogenase; Provisional.	0
NZ_CP026067.1\|WP_000877364.1\|451081_451954_+\|intercellular-adhesin-biosynthesis-polysaccharide-N-deacetylase	gnl\|CDD\|188448	TIGR03933, Poly-beta-16-N-acetyl-D-glucosamine_N-deacetylase, intercellular adhesin biosynthesis polysaccharide N-deacetylase. A common motif in bacterial biosynthesis of polysaccharide for export is modification that follows polymerization. This model describes a subfamily of polysaccharide N-deacetylases that acts on poly-beta-1,6-N-acetyl-D-glyscosamine as produced by Staphylococcus epidermidis and S. aureus. The end product in these species is designated polysaccharide intercellular adhesin (PIA), and this gene designated icaB (intercellular adhesion protein B). [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Cellular processes, Pathogenesis].	6.15216e-151
NZ_CP026067.1\|WP_000592606.1\|457580_458339_-\|imidazole-glycerol-phosphate-synthase-subunit-HisF	gnl\|CDD\|234996	PRK02083, PRK02083, imidazole glycerol phosphate synthase subunit HisF; Provisional.	1.14549e-155
NZ_CP026067.1\|WP_000186284.1\|456951_457584_-\|bifunctional-phosphoribosyl-AMP-cyclohydrolase/phosphoribosyl-ATP-diphosphatase-HisIE	gnl\|CDD\|235067	PRK02759, PRK02759, bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE.	1.51084e-110
NZ_CP026067.1\|WP_047213039.1\|460154_461168_-\|histidinol-phosphate-aminotransferase-family-protein	gnl\|CDD\|223157	COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism].	1.50634e-79
NZ_CP026067.1\|WP_000565312.1\|445870_446638_-\|tyrosine-protein-phosphatase	gnl\|CDD\|226870	COG4464, CapC, Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	1.88344e-144
NZ_CP026067.1\|WP_072358118.1\|453383_455426_-\|YSIRK-domain-containing-triacylglycerol-lipase-Lip1	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	8.21827e-82
NZ_CP026067.1\|WP_000640270.1\|459607_460186_-\|imidazoleglycerol-phosphate-dehydratase-HisB	gnl\|CDD\|153419	cd07914, IGPD, Imidazoleglycerol-phosphate dehydratase. Imidazoleglycerol-phosphate dehydratase (IGPD; EC 4.2.1.19) catalyzes the dehydration of imidazole glycerol phosphate to imidazole acetol phosphate, the sixth step of histidine biosynthesis in plants and microorganisms where the histidine is synthesized de novo. There is an internal repeat in the protein domain that is related by pseudo-dyad symmetry, perhaps as a result of an ancient gene duplication. The apo-form of IGPD exists as a catalytically inactive trimer which, in the presence of specific divalent metal cations such as manganese (Mn2+), cobalt (Co2+), cadmium (Cd2+), nickel (Ni2+), iron (Fe2+) and zinc (Zn2+), assembles to form a biologically active high molecular weight metalloenzyme; a 24-mer with 4-3-2 symmetry. Each 24-mer has 24 active sites, and contains around 1.5 metal ions per monomer, each monomer contributing residues to three separate active sites. IGPD enzymes are monofunctional in fungi, plants, archaea and some eubacteria while they are encoded as bifunctional enzymes in other eubacteria, such that the enzyme is fused to histidinol-phosphate phosphatase, the penultimate enzyme of the histidine biosynthesis pathway. The histidine biosynthesis pathway is a potential target for development of herbicides, and IGPD is a target for the triazole phosphonate herbicides.	7.13364e-103
NZ_CP026067.1\|WP_001159430.1\|449577_450816_+\|poly-beta-1,6-N-acetyl-D-glucosamine-synthase	gnl\|CDD\|274866	TIGR03937, Poly-beta-16-N-acetyl-D-glucosamine_synthase, poly-beta-1,6 N-acetyl-D-glucosamine synthase. Members of this protein family are biofilm-forming enzymes that polymerize N-acetyl-D-glucosamine residues in beta(1,6) linkage. One named members is IcaA (intercellular adhesin protein A), an enzyme that acts (with aid of subunit IcaD) in Polysaccharide Intercellular Adhesin (PIA) biosynthesis in Staphylococcus epidermis). The homologous member in E. coli is designated PgaC. Members are often encoded next to a polysaccharide deacetylase and involved in biofilm formation. Note that chitin, although also made from N-acetylglucosamine, is formed with beta-1,4 linkages.	0
NZ_CP026067.1\|WP_000659677.1\|447343_448006_-\|capsular-polysaccharide-biosynthesis-protein-CapA	gnl\|CDD\|226453	COG3944, COG3944, Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane].	1.17617e-89
NZ_CP026067.1\|WP_000723844.1\|451940_452993_+\|acyltransferase-family-protein	gnl\|CDD\|226446	COG3936, COG3936, Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism].	3.49276e-114
NZ_CP026067.1\|WP_000301937.1\|444656_445133_-\|peptide-methionine-(S)-S-oxide-reductase	gnl\|CDD\|235497	PRK05528, PRK05528, peptide-methionine (S)-S-oxide reductase.	7.42007e-107

>NZ_CP026067.1|WP_000723844.1|451940_452993_+|acyltransferase-family-protein
MKKIRLELVYLRAIICAIIIVTHLLTQITLKHENMEGGSLVLQFYIRNIVIFGTPCFIILSQLLTTLNYQKVTYRYLTTRVKYILIPYILMGLFYSYSESLLTDTSFQKQFIENVLLGQWYGYFIVVIMQFFILSYIIFKINYNLFNSKILLLLSFILQQSFLYYFTNNTAFHDTVLHYYPLSENTIIFGWIFYFFLGAYMGYNYERVLNFLERYLVIMIVLAVATYFVFIALANGDYWNVTSFSYSLTPYNSIMFIVILGICTHFKTMLFNTIQMISAFSFFIYLLHPIILDSLFAYTNIFEDNTMVFLAISLLFILGLCIGVGMILREFYIFRFIIGKQPYKLNINAY
>NZ_CP026067.1|WP_000877364.1|451081_451954_+|intercellular-adhesin-biosynthesis-polysaccharide-N-deacetylase
MKYRKLIILVLSILIILPVSTLDGHHIANADDDPPKKLKYKENSALALNYHRVRKANFLNNFIYFFSSSKEIKNYSVSQSQFESQIKWLKSHDAKFLTLKEFLYYKKKGKFPKRSVWINFDDMDETIYENAYPILKKYKIPATGFIITGHVGEENFHNLDMISKKELKEMYKTGLWEFETHTHDLHNLSKNNKSKLMKSSEATIIKDLNKSEKYLTKNFKKSQKTIAYPYGLMNDDKLPVIKKAGLKYGFSLEEKAVTPNSNDYYIPRILISDDAFEHLIKRWDGFHEKD
>NZ_CP026067.1|WP_000240580.1|450779_451085_+|intracellular-adhesion-protein-D
MVKPRQREYPTLKSSLNIVRETALIAISCVFWIYCLVVLLVYIGTIFEIHDESINTIRVALNIENTEILDIFETMGIFAIIIFVFFTISILIQKWQRGRES
>NZ_CP026067.1|WP_001159430.1|449577_450816_+|poly-beta-1,6-N-acetyl-D-glucosamine-synthase
MQFFNFLLFYPVFMSIYWIVGSIYFYFTREIRYSLNKKPDINVDELEGITFLLACYNESETIEDTLSNVLALKYEKKEIIIINDGSSDNTAELIYKIKENNDFIFVDLQENRGKANALNQGIKQASYDYVMCLDADTIVDQDAPYYMIENFKHDPKLGAVTGNPRIRNKSSILGKIQTIEYASLIGCIKRSQTLAGAVNTISGVFTLFKKSAVVDVGYWDTDMITEDIAVSWKLHLRGYRIKYEPLAMCWMLVPETLGGLWKQRVRWAQGGHEVLLRDFFSTMKTKRFPLYILMFEQIISILWVYIVLLYLGYLFITANFLDYTFMTYSFSIFLLSSFTMTFINVIQFTVALFIDSRYEKKNMAGLIFVSWYPTVYWIINAAVVLVAFPKALKRKKGGYATWSSPDRGNTQR
>NZ_CP026067.1|WP_000653261.1|448853_449414_-|TetR/AcrR-family-transcriptional-regulator
MKDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNNIIMMNQNKSNYSIDALYQFLFEFIFDIEERYIRMYVQLSNTPEEFSGNIYGQIQDLNQSLSKEIAKFYDESKIKMTKEDFQNLILLFLESWYLKASFSQKFGAVEESKSQFKDEVYSLLNIFLKK
>NZ_CP026067.1|WP_000659677.1|447343_448006_-|capsular-polysaccharide-biosynthesis-protein-CapA
MKEKFDLVKLLNILKKNIKLLLILPAICLVVSAALTFFVMPDKYTASTQILVNMKKSSSDLAFQNVQSSLQSVNTYTEIIKSPRILDKVSREFDGQYSTAELNSFLKVTNQTNSQIITVSVTTGNKSESDKIVNRISKVFAHDMPKIMSVDNVTILSSAHDNAVKVSPIVSVNLVISIIVGIVLAILIIFLKELLDKRIKTEEDVESQLGLPILGSIQKF
>NZ_CP026067.1|WP_000185863.1|446634_447327_-|polysaccharide-biosynthesis-tyrosine-autokinase
MTNTRRSTSSLIVHEQPKSPISEKFRGIRSNIMFANPDSAVQSIVITSEAPGAGKSTIAANLAVAYAQAGYKTLIVDGDMRKPTQHYIFNLPNNEGLSSLLLNWSTYQDSIISTEIQDLDVLTSGPIPPNPSELITSRAFANLYDTLLMNYNFVIIDTPPVNTVTDAQLFSKFTGNVVYVVNSENNNKDEVKKGKELIEATGAKLLGVVLNRMPKDKSASYYAYYGTDES
>NZ_CP026067.1|WP_000565312.1|445870_446638_-|tyrosine-protein-phosphatase
MIDIHNHILVDIDDGPKTIEKSIALLKQAKDEGVTSIVATPHHLHPRYDNTFQQVLVKLAELRTHPEVQALDIKLFPGQEIRITDSILQGLDNGSIQGINRSKYLLIEFPTGEVPHYTKQLFFEIQSRGYIPIIAHPERNRSIAKNPEILYELVANGALSQLTSSSLVGGFGKNIQKLSLQFIECNLAHFVASDAHSCDQRPFLMQELFHNHKLKKYSNDIEALLRNASSVINDNFVYLDRPTKPGKVKSFLKWF
>NZ_CP026067.1|WP_000244266.1|445135_445636_-|GNAT-family-N-acetyltransferase
MVLRKVIMQDLDQIIALENIGFSPEEAATPEALKLRIEQIQETFIVAEKNDEVIGYINGPVIKERYISDDLFKNVPTNNSEGGYISVLGLVVAPNYQGQGIAGRLLNYFENLAKNQHRHGVTLTCRESLISFYEKYGYRNEGVSESCHGGIKWYNLVKNIKKDDEV
>NZ_CP026067.1|WP_000301937.1|444656_445133_-|peptide-methionine-(S)-S-oxide-reductase
MAVVYVAGGCLWGVEAFFTTIPGIIHTEAGRANGRSSKLDSPYDGYAECVKLHFDDRMLTITDIMNYLFEIIDPYSVNRQGNDIGEKYRTGLYSCVDDHLIEARQFIERRKDRDQIAVEVLPLSNYIKSAEEHQQHLEKYPEDMHMCHISKDLLNKYK
>NZ_CP026067.1|WP_072358118.1|453383_455426_-|YSIRK-domain-containing-triacylglycerol-lipase-Lip1
MKSQNKYSIRKFSVGASSILIATLLFLSGGQAQAAEKQVNMGNSQEDTVTAQSIGDQQTRENANYQRENGVDEQQHTENLTKNLHNDKTISEENHRKTDDLNKDQLKDDKKSSLNNKNIQRDTTKNNNANPSDVNQGLEQAINDGKQSKVASQQQSKETDNSQDSNANNNLPSQSRTKEALPLNKSNQTSQREIVNKTEIEKVQPQQNNQANDKITNYNFNNEKEVKPQKDEKTLSVSDLKNNQKSPVEPTKDNDKKNGLNLLKSSAVATLPNKGTKELTAKAKGDQTNKVAKQGQYKNQDPIVLVHGFNGFTDDINPSVLAHYWGGNKMNIRQDLEENGYKAYEASISAFGSNYDRAVELYYYIKGGRVDYGAAHAAKYGHERYGKTYEGIYKDWKPGQKVHLVGHSMGGQTIRQLEELLRNGNREEIEYQKKHGGEISPLFKGNNDNMISSITTLGTPHNGTHASDLAGNEALVRQIVFDIGKMFGNKNSRVDFGLAQWGLKQKPNESYIDYVKRVKQSNLWKSKDNGFYDLTREGATDLNRKTSLNPNIVYKTYTGEATHKALNSDRQKADLNMFFPFVITGNLIGKATEKEWRENDGLVSVISSQHPFNQAYTNATDKIQKGIWQVTPTKHDWDHVDFVGQDSSDTVRTREELQDFWHHLADDLVKTEKVTDTKQA
>NZ_CP026067.1|WP_047213037.1|456198_456411_-|hypothetical-protein
MKKLFNEYFFTTSQATALIIFSLPMTDLFTKNFLLYMLLFIVIIGSTFFIERELSKKYSLQEKAKKLCLS
>NZ_CP026067.1|WP_000186284.1|456951_457584_-|bifunctional-phosphoribosyl-AMP-cyclohydrolase/phosphoribosyl-ATP-diphosphatase-HisIE
MTNYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHTQRVKDIHVDCDNDTILIDVIPNGPTCHTGSQSCFNTEVPFSVQTLAQTVQDSAQSNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKAFVSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQNIEQW
>NZ_CP026067.1|WP_000592606.1|457580_458339_-|imidazole-glycerol-phosphate-synthase-subunit-HisF
MIKKRIIPCLDVKDGRVVKGIQFKGLRDIGNPVDLAMYYNEAGADELVFLDISKTEEGHSLMLEVIEQTASRLFIPLTVGGGIQSLDDITQLLNHGADKVSLNSSALKNPQLIKQASDKFGRQCICIAIDSYYDPERKAHYCCTHGGKKMTNIKVYDWVQQVEQLGAGELLVTSMGHDGMKQGFDIEHLAKIKSLVNIPIIASGGSGNAQHFVELFNQTDVSAGLAASILHDRETTVQSIKEVIRQGGIAVR
>NZ_CP026067.1|WP_000571733.1|458335_459040_-|1-(5-phosphoribosyl)-5-((5--phosphoribosylamino)methylideneamino)imidazole-4--carboxamide-isomerase
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQHAREFDYIKSLRRLTTKDIEVGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVKQLSDIPLGGIIYTDIAKDGKMSGPNFELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLK
>NZ_CP026067.1|WP_000635617.1|459032_459611_-|imidazole-glycerol-phosphate-synthase-subunit-HisH
MIVIVDYGLGNISNVKRAIEHLGYEVVVSNNPKIIDQAETIILPGVGHFKDAMSEIKRLNLDAILAKNTDKKMIGICLGMQLMYEHSDEGDASGLGFIPGNISRIQTEYPVPHLGWNNLVSKHPMLNQDVYFVHSYQAPMSENVIAYAQYGTDIPAIVQFNNYIGIQFHPEKSGTYGLQILRQAIQGGFIND
>NZ_CP026067.1|WP_000640270.1|459607_460186_-|imidazoleglycerol-phosphate-dehydratase-HisB
MIYQKQRNTAETQLNISISDDQSPSHINTGVGFLNHMLTLFTFHSGLSLNIEAQGDIDVDDHHVTEDIGIVIGQLLLEMIKDKKHFVRYGTMYIPMDETLARVVVDISGRPYLSFNATLSKEKVGTFDTELVEEFFRAVVINARLTTHIDLIRGGNTHHEIEAIFKAFSRALGIALTATDDQRVPSSKGVIE
>NZ_CP026067.1|WP_047213039.1|460154_461168_-|histidinol-phosphate-aminotransferase-family-protein
MIYIDKNESPVTPLDEKTMTSIISATPYNLYPDAAYEQFKDAYAKFYGLSSEQIIAGNGSDELIQKLMLIMPEGLALTLNPDFFMYQAYAAQVNREIAFVDAGSDLTFDLETILTKIDEVQPSFFIMSNPHNPSGKQFDTAFLTAIADKMKAINGYFVIDEAYLDYGMAYDVELAPHILRMRTLSKAFGIAGLRLGVLISTAETIQRIQTIEHPYPLNVFTLNIATYIFRHREETSRFLTMQRQLANQLKQIFDTHVADKMSVFPSNANFVLTKGSAAQQLGQYVYEQGFKPRFYDEQVMKGYVRYSIATASQLKQLEEIVKEWSTKYDLSKTTKHS
>NZ_CP026067.1|WP_000930656.1|461183_462434_-|histidinol-dehydrogenase
MLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHEQIKAAFDTLDEKTKQALQQSYERIKAYQESIKQTNQQLEKSVECYEIYHPLESVGIYVPGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVLAACYITQVNQVFQVGGAQSIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDDTADLDAIVYDVFAQAEHDELARTYVISEDAQVLKDLESRIAKALPNVDRYDIVSKSIANQHYLIHASNFDEACYVMNTIAPEHASIQTVNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTNRTARFTNGLSVNDFLTRNTVIHLSKDTFDQIADSAQHIAHVEALYNHQQSILIRQS
>NZ_CP026067.1|WP_000944131.1|462426_463041_-|ATP-phosphoribosyltransferase
MLRIAIAKGRLMDSLINYLDAIEFTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVEQGIADIGIVGSDILDERHYNVNNLLDMPFGACHFAVAAKPETTKYHKIATSYVHTAEAYFKSKGIDVELIKLSGSVELACVVDMVDGIVDIVQTGTTLEANGLVEKQHISDINARLITNKAAYFKKSQLIEQFIRSLEVSIANA

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Crispr_ID: NZ_CP026067_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP026067_3

977243-977332

Unclear

Consensus_repeat	Method
AGTTGGGGTGTGGGCCCCAACACAGAAGCTG	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP026067_3

>merge|NZ_CP026067|3|977243-977332|CRISPRCasFinder
AGTTGGGGTGTGGGCCCCAACACAGAAGCTGACGAAAAGTCAGCTTACGATAAAGTGCAAGTTGGGGTGTGGGCCCCAACATAGAAGCTG

>NZ_CP026067|3|3|977243-977332|CRISPRCasFinder
AGTTGGGGTGTGGGCCCCAACACAGAAGCTG	ACGAAAAGTCAGCTTACGATAAAGTGCA
AGTTGGGGTGTGGGCCCCAACATAGAAGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP026067.1\|WP_001167888.1\|974926_977020_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	unknown	unknown	gnl\|CDD\|273520
NZ_CP026067.1\|WP_000148607.1\|977665_978547_+\|Hsp33-family-molecular-chaperone-HslO	unknown	unknown	gnl\|CDD\|234643
NZ_CP026067.1\|WP_047213181.1\|968754_970281_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
NZ_CP026067.1\|WP_001176701.1\|972829_974125_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|366502
NZ_CP026067.1\|WP_001790128.1\|981886_981979_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_000613714.1\|981016_981493_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|223872
NZ_CP026067.1\|WP_000551283.1\|974129_974669_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NZ_CP026067.1\|WP_000792417.1\|971751_972144_+\|septum-formation-initiator-family-protein	unknown	unknown	gnl\|CDD\|225471
NZ_CP026067.1\|WP_047213187.1\|982031_983519_+\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NZ_CP026067.1\|WP_000649791.1\|964686_965259_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|223271
NZ_CP026067.1\|WP_001154302.1\|980654_981020_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|238298
NZ_CP026067.1\|WP_000951460.1\|970280_971474_+\|nucleotide-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|226465
NZ_CP026067.1\|WP_000690439.1\|998445_999006_+\|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	unknown	unknown	gnl\|CDD\|237411
NZ_CP026067.1\|WP_000021445.1\|972248_972650_+\|RNA-binding-protein-S1	unknown	unknown	gnl\|CDD\|236305
NZ_CP026067.1\|WP_001234988.1\|971470_971734_+\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|224109
NZ_CP026067.1\|WP_000799253.1\|996068_997451_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP026067.1\|WP_047213184.1\|978725_979658_+\|cysteine-synthase-A	unknown	unknown	gnl\|CDD\|273465
NZ_CP026067.1\|WP_047213179.1\|965258_968765_+\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
NZ_CP026067.1\|WP_000167928.1\|979873_980677_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
NZ_CP026067.1\|WP_000034728.1\|997554_998442_+\|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS	unknown	unknown	gnl\|CDD\|179769

Protein	Function_ID	Function_description	E-value
NZ_CP026067.1\|WP_001167888.1\|974926_977020_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP026067.1\|WP_000148607.1\|977665_978547_+\|Hsp33-family-molecular-chaperone-HslO	gnl\|CDD\|234643	PRK00114, hslO, Hsp33 family molecular chaperone HslO.	1.29884e-159
NZ_CP026067.1\|WP_047213181.1\|968754_970281_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	2.05199e-87
NZ_CP026067.1\|WP_001176701.1\|972829_974125_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|366502	pfam01171, ATP_bind_3, PP-loop family. This family of proteins belongs to the PP-loop superfamily.	3.10271e-78
NZ_CP026067.1\|WP_000034728.1\|997554_998442_+\|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS	gnl\|CDD\|179769	PRK04180, PRK04180, pyridoxal 5'-phosphate synthase lyase subunit PdxS.	0
NZ_CP026067.1\|WP_000613714.1\|981016_981493_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	9.12434e-73
NZ_CP026067.1\|WP_000551283.1\|974129_974669_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	4.50006e-94
NZ_CP026067.1\|WP_000792417.1\|971751_972144_+\|septum-formation-initiator-family-protein	gnl\|CDD\|225471	COG2919, COG2919, Septum formation initiator [Cell division and chromosome partitioning].	3.2193e-21
NZ_CP026067.1\|WP_047213187.1\|982031_983519_+\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NZ_CP026067.1\|WP_000649791.1\|964686_965259_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|223271	COG0193, Pth, Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis].	5.81135e-97
NZ_CP026067.1\|WP_001154302.1\|980654_981020_+\|dihydroneopterin-aldolase	gnl\|CDD\|238298	cd00534, DHNA_DHNTPE, Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is DHNA which catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. Though it is known that DHNTPE catalyzes the epimerization of dihydroneopterin triphosphate to dihydromonapterin triphosphate, the biological role of this enzyme is still unclear. It is hypothesized that it is not an essential protein since a folX knockout in E. coli has a normal phenotype and the fact that folX is not present in H. influenza. In addition both enzymes have been shown to be able to compensate for the other's activity albeit at slower reaction rates. The functional enzyme for both is an octamer of identical subunits. Mammals lack many of the enzymes in the folate pathway including, DHNA and DHNTPE.	1.74147e-48
NZ_CP026067.1\|WP_000951460.1\|970280_971474_+\|nucleotide-pyrophosphohydrolase	gnl\|CDD\|226465	COG3956, COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only].	0
NZ_CP026067.1\|WP_000690439.1\|998445_999006_+\|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	gnl\|CDD\|237411	PRK13525, PRK13525, pyridoxal 5'-phosphate synthase glutaminase subunit PdxT.	9.71225e-112
NZ_CP026067.1\|WP_000021445.1\|972248_972650_+\|RNA-binding-protein-S1	gnl\|CDD\|236305	PRK08582, PRK08582, RNA-binding protein S1.	4.42227e-78
NZ_CP026067.1\|WP_001234988.1\|971470_971734_+\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	2.63429e-32
NZ_CP026067.1\|WP_000799253.1\|996068_997451_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	2.73424e-131
NZ_CP026067.1\|WP_047213184.1\|978725_979658_+\|cysteine-synthase-A	gnl\|CDD\|273465	TIGR01139, Cysteine_synthase, cysteine synthase A. This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family].	3.8342e-167
NZ_CP026067.1\|WP_047213179.1\|965258_968765_+\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NZ_CP026067.1\|WP_000167928.1\|979873_980677_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	1.16187e-122

>NZ_CP026067.1|WP_001167888.1|974926_977020_+|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein
MQKAFRNVLVIVIIGVIIFGLFSYLNGNGNMPKQLTYNQFTEKLEKGDLKTLEIQPQQNVYMVSGKTKNDEDYSSTILYNNEKELQKITDAAKKQNGVKLTIKEEEKQSVFVSILSTLIPVVVIALLFIFFLSQAQGGGSGGRMMNFGKSKAKMYDNNKRRVRFSDVAGADEEKQELIEIVDFLKDNKKFKEMGSRIPKGVLLVGPPGTGKTLLARAVAGEAGAPFFSISGSDFVEMFVGVGASRVRDLFDNAKKNAPCIIFIDEIDAVGRQRGAGVGGGHDEREQTLNQLLVEMDGFGENEGIIMIAATNRPDILDPALLRPGRFDRQIQVGRPDVKGREAILHVHAKNKPLDETVDLKAISQRTPGFSGADLENLLNEASLIAVREGKKKIDMRDIEEATDRVIAGPAKKSRVISKKERNIVAHHEAGHTIIGMVLDEAEVVHKVTIVPRGQAGGYAMMLPKQDRFLMTEQELLDKICGLLGGRVSEDINFNEVSTGASNDFERATQIARSMVTQYGMSKKLGPLQFGHSNGQVFLGKDMQGEPNYSSQIAYEIDKEVQRIVKEQYERCKQILLEHKEQLILIAETLLTEETLVAEQIQSLFYEGKLPEIDYDAAKVVKDEDSEFNDGKFGKSYEEIRKEQLEDGQRDESEDRKEEKDIAEDKKEADKSDEKDEPAHRQAPNIEKPYDPNHPDNK
>NZ_CP026067.1|WP_000551283.1|974129_974669_+|hypoxanthine-phosphoribosyltransferase
MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLSIDFMDVSSYHGGTESTGEVQIIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVNSLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYRELYRNLPYIGTLKPEVYSN
>NZ_CP026067.1|WP_001176701.1|972829_974125_+|tRNA-lysidine(34)-synthetase-TilS
MQLNSNGWHVDDHIVVAVSTGIDSMCLLYQLLKDYKDSYRKLTCLHVNHGVRSASIEEARFLEAYCERHHIDLHIKKLDLSHSLNRNNSIQNEARIKRYEWFDEMMNVLEADVLLTAHHLDDQLETIMYRIFNGKSTRNKLGFDELSKRKGYQIYRPLLAVSKKEIKQFQERYHIPYFEDESNKDNKYVRNDIRNRIIPAIDENNQLKVSHLLKLKQWHDEQYDILQYSAKQFIQEFVKFDEQSKYLEVSRQSFNDLPNSLKMVVLDCLLSKYYELFNISAKTYEEWFKQFSSKKAQFSINLTDKWIIQIAYGKLIIMAKNNGDTYFRVQTIEKPGNYIFNKYRLEIHSNLPKCLFPLSVRTRQSGDTFKLNGRDGYKKVNRLFIDCKVQQWVRDQMPIVLDKQQRIIAVGDLYQQQTIKQWIIISKNGDE
>NZ_CP026067.1|WP_000021445.1|972248_972650_+|RNA-binding-protein-S1
MSIEVGNKLKGKVTGIKKFGAFVELPEGKSGLVHISEVADNYVENVEEHLSVGDEVDVKVLSIADDGKISLSIKKAKDRPRRQHTSKPSHQKPVQKAEDFEKKLSNFLKDSEDKLTSIKRQTESRRGGKGSRR
>NZ_CP026067.1|WP_000792417.1|971751_972144_+|septum-formation-initiator-family-protein
MKNKVEHIENQYTSQENKKKQRQKMKMRVVRRRITVFAGVLLAIIVVLSILLVVQKHRNDIDAQERKAKEAQFQKQQNEEIALKEKLNNLNDKDYIEKIARDDYYLSNKGEVIFRLPEDKDSSSSKSSKK
>NZ_CP026067.1|WP_001234988.1|971470_971734_+|RNA-binding-S4-domain-containing-protein
MRLDKYLKVSRLIKRRTLAKEVSDQGRITINGNVAKAGSDVKVEDVLTIRFGQKLVTVKVTALNEHASKDNAKGMYEIIEERRLEEA
>NZ_CP026067.1|WP_000951460.1|970280_971474_+|nucleotide-pyrophosphohydrolase
MAHTITIVGLGNYGIDDLPLGIYKFLKTQNKVYARTLDHPVIESLQDELTFQSFDHVYETHDQFEDVYNDIVAQLVEAANEKDIVYAVPGHPRVAETTTVKLLALAKDNTDIDVKVLGGKSFIDDVFEAVNVDPNDGFTLLDATSLQEVTLNVRTHTLITQVYSAMVAANLKITLMERYPDDYPVQIVTGARSDGADNVVTCPLYELDHDENAFNNLTSVFVPKITTPTYLYHDFDFATEVIDTLVDEDKGCPWDKVQTHETLKRYLLEETFELFEAIDNEDDWHMIEELGDILLQVLLHTSIGKKEGYIDIKEVITSLNAKMIRRHPHIFGDANAETIDDLKEIWSKAKDAEGKQPRVKFEKVFAEHFLNLYEKTKDKSFDEAALKQWLEKGESNT
>NZ_CP026067.1|WP_047213181.1|968754_970281_+|polysaccharide-biosynthesis-protein
MKHKEAFNGVVVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGEYHSDEAYAKAVAYIQLVGILLFIAIFVFANNIAYMMGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVGIIIVTIVIFVDRGWTIYEAGTIAILASTIGFLGSSIYLVAHRPFKFKMVNNTAKIVWKQFALSVLIFAISQLIVILWQVIDSVTIIKSLQAIRVPFDVAITEKGVYDRGASFIQMGLIVTTTFSFALIPLLSDAIKMNNQVLMNRYANASLKITILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMMAGLVIKFILNIILIRLSGIIGASISTVVSLIIFGTIIHIAVTRKYHLHAMRRFFINVVLGMVFMSIVVQCVLNIVTTHGRITGLIELLCAAVLGIIALFFYIFRFNVLTYKELTYLPFGSKLYQIKKGRR
>NZ_CP026067.1|WP_047213179.1|965258_968765_+|transcription-repair-coupling-factor
MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKGTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFVDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTEIDSIRDFDVETQRSKDNIEEVDITTASDYIITEEVISHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIDYFQKDAIIAVDEFNRIKETEESLTVESDTFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA
>NZ_CP026067.1|WP_000649791.1|964686_965259_+|aminoacyl-tRNA-hydrolase
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDHVMNEFNGEVK
>NZ_CP026067.1|WP_000148607.1|977665_978547_+|Hsp33-family-molecular-chaperone-HslO
MTHDYIVKALAFDGEIRAYAALTTETVQEAQTRHYTWPTASAAMGRTMTATAMMGAMLKGDQKLTVTVDGQGPIGRIIADANAKGEVRAYVDHPQTHFPLNEQGKLDVRRAVGTNGSIMVVKDVGMKDYFSGASPIVSGELGEDFTYYYATSEQTPSSVGLGVLVNPDNTIKAAGGFIIQVMPGAKDETISKLEKAISEMTPVSKLIEQGLTPEGLLNEILGKDHVQILEKMPVQFECNCSHEKFLNAIKGLGEAEIQNMIKEDHGAEAVCHFCGNKYKYTEEELNVLLESLV
>NZ_CP026067.1|WP_047213184.1|978725_979658_+|cysteine-synthase-A
MAQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLDYQNPGGSVKDRIALAMIEKAEREGKIKPGDTIVEPTSGNTGIGLAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPGSEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTGPELLQQFEGKTIDAFLAGVGTGGTLSGVGKVLKKEYPNIEVVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYDSIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVVTVLPSNGERYLSTPLYSFDD
>NZ_CP026067.1|WP_000167928.1|979873_980677_+|dihydropteroate-synthase
MTKTKIMGILNVTPDSFSDGGKFNNVESAVTRVKAMMDEGADIIDVGGASTRPGHEMISLEEELNRVLPVVEAIVGFDVKISVDTFRSEVAEACLKLGVDIINDQWAGLYDHRMFQVVAKYDAEIVLMHNGNGNRDEPVVEEMLTSLLAQAHQAKIAGISSNKIWLDPGIGFAKTRNEEAEVMARLDELVATEYPVLLATSRKRFTKEMMGYDTTPVERDEVTAATTAYGIMKGVRAVRVHNVELNAKLAKGIDFLKENENARHNLS
>NZ_CP026067.1|WP_001154302.1|980654_981020_+|dihydroneopterin-aldolase
MQDTIFLKGMRFYGYHGALSAENEIGQIFKVDVTLKVDLAEAGRTDNVIDTVHYGEVFEEVKSIMEGKAVNLLEHLAERIANRINSQYNRVMETKVRITKENPPIPGHYDGVGIEIVRENK
>NZ_CP026067.1|WP_000613714.1|981016_981493_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MIQAYLGLGSNIGDRESQLNDAIKILNEYDGINVFNISPIYETAPVGYTEQPNFLNLCVEIQTTLTVLQLLECCLKTEECLHRVRKERWGPRTLDVDILLYGEEMIDLPKLSVPHPRMNERAFVLIPLNDIAANVIEPRSKLKVKDLVFVDDSVKRYK
>NZ_CP026067.1|WP_001790128.1|981886_981979_+|hypothetical-protein
MVNDKVLETSKEMYVEQKCLIFYKTLKENV
>NZ_CP026067.1|WP_047213187.1|982031_983519_+|lysine--tRNA-ligase
MSEEMNDQMLVRRQKLQELYDLGIDPFGSKFDRSGLSSDLKEEWDQYSKEELVEKEADSHVAIAGRLMTKRGKGKAGFAHVQDLAGQIQIYVRKDQVGDDEFDLWKNADLGDIVGVEGVMFKTNTGELSVKAKKFTLLTKSLRPLPDKFHGLQDIEQRYRQRYLDLITNEDSTRTFINRSKIIQEMRNYLNNKGFLEVETPMMHQIAGGAAARPFVTHHNALDATLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIELYEAYADYHDIMDLTESMVRHIANEVLGSAKVQYNGETIDLESAWTRLHIVDAVKEATGVDFYEIKSDEEAKALAKEHGIEIKDTMKYGHILNEFFEQKVEETLIQPTFIYGHPTEISPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQKGRFEAQLVEKAQGNDEAHEMDEDYIEALEYGMPPTGGLGIGIDRLVMLLTDSPSIRDVLLFPYMRQK
>NZ_CP026067.1|WP_000799253.1|996068_997451_-|PLP-dependent-aminotransferase-family-protein
MKNTLYHQLYEKLKKQIIEGQFKEGDKFYSKRQLSKHLSISQTTVEHAYQLLLDEGYIYSRPRSGYFVSEIESLTILNNQPIPSLFDDDSYKPKASDEAYDYAFNLDEIDTKHFPIELFRKYSKDLYDTNHLNQLRRGHFQGELHLRFQLAFYLFTNRGVICDPNQIIIGSSTEQLVNQLVDLLYTSTFIIEKPSYPPIKNILDKKQVEYEQIEVEDNGINVDEVIKSQKNIVYITPSHQFPTGYVMDLKKRTQLIQWAQEKEERFIIEDDYDSEFRYFGKPIPAIQGLYSRGEKVIYISTFSKSIFPSCRVAYMVLPYSIMKKYHSQNHIEGNTVPVHMQNLIATFISSGGFERHLNKMRRIYRRKLTYILNRLKPYKEQLDIQGAETGMHFTITVKNGLTLQECLDRANKVKLKLQVYNFDDDQDYKKTPKFILGFGGIDDDALKPHVDALIKSLIIK
>NZ_CP026067.1|WP_000034728.1|997554_998442_+|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS
MSKIIGSDRVKRGMAEMQKGGVIMDVVNAEQARIAEEAGAVAVMALERVPSDIRAAGGVARMANPKIVEEVMNAVSIPVMAKARIGHITEARVLEAMGVDYIDESEVLTPADEEYHLRKDQFTVPFVCGCRNLGEAARRIGEGAAMLRTKGEPGTGNIVEAVRHMRQVNSEVSRLTVMNDDEIMTFAKDIGAPYEILKQIKDNGRLPVVNFAAGGVATPQDAALMMELGADGVFVGSGIFKSEDPEKFAKAIVQATTHYQDYELIGRLASELGTAMKGLDINQLSLEERMQERGW
>NZ_CP026067.1|WP_000690439.1|998445_999006_+|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT
MKIGVLALQGAVREHIRHIELSGHEGIAVKKVEQLEEIEGLILPGGESTTLRRLMNLYGFKEALQNSTLPMFGTCAGLIVLAQDIVGEEGYLNKLNITVQRNSFGRQVDSFETELDIKGIATDIEGVFIRAPHIEKVGQGVDILCKVNEKIVAVQQGKYLGVSFHPELTDDYRVTDYFINHIVKKA

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Crispr_ID: NZ_CP026067_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP026067_4

1537721-1537817

Orphan

Consensus_repeat	Method
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP026067_4

>merge|NZ_CP026067|4|1537721-1537817|CRISPRCasFinder
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGGTAAAAGAGGGATACTTGCGCTGAGCGCATGCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG

>NZ_CP026067|4|4|1537721-1537817|CRISPRCasFinder
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG	TAAAAGAGGGATACTTGCGCTGAGCGCAT
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP026067.1\|WP_000273259.1\|1534452_1535259_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NZ_CP026067.1\|WP_000032747.1\|1526181_1528371_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	unknown	unknown	gnl\|CDD\|234921
NZ_CP026067.1\|WP_031927754.1\|1532939_1534187_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|237507
NZ_CP026067.1\|WP_001289618.1\|1544044_1544278_-\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|239274
NZ_CP026067.1\|WP_000709282.1\|1531439_1532918_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NZ_CP026067.1\|WP_000437472.1\|1541820_1542087_+\|phosphocarrier-protein-HPr	unknown	unknown	gnl\|CDD\|237503
NZ_CP026067.1\|WP_047213340.1\|1539832_1541071_+\|class-I-SAM-dependent-rRNA-methyltransferase	unknown	unknown	gnl\|CDD\|224017
NZ_CP026067.1\|WP_000848351.1\|1525252_1525516_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	unknown	unknown	gnl\|CDD\|224741
NZ_CP026067.1\|WP_000921977.1\|1535251_1536652_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NZ_CP026067.1\|WP_000030808.1\|1529827_1530856_+\|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl\|CDD\|235439
NZ_CP026067.1\|WP_000064214.1\|1537826_1537961_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_000009069.1\|1538112_1539408_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_000505962.1\|1541124_1541667_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368297
NZ_CP026067.1\|WP_000666799.1\|1525517_1526189_+\|phosphoribosylformylglycinamidine-synthase-I	unknown	unknown	gnl\|CDD\|235140
NZ_CP026067.1\|WP_031927753.1\|1530858_1531425_+\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|223376
NZ_CP026067.1\|WP_031927757.1\|1542089_1543808_+\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NZ_CP026067.1\|WP_000514290.1\|1546985_1547648_+\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643
NZ_CP026067.1\|WP_000381852.1\|1544475_1545837_+\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NZ_CP026067.1\|WP_000638453.1\|1545833_1546853_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|224213
NZ_CP026067.1\|WP_000033477.1\|1536667_1537243_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|227065

Protein	Function_ID	Function_description	E-value
NZ_CP026067.1\|WP_000273259.1\|1534452_1535259_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	1.09792e-29
NZ_CP026067.1\|WP_000032747.1\|1526181_1528371_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	gnl\|CDD\|234921	PRK01213, PRK01213, phosphoribosylformylglycinamidine synthase subunit PurL.	0
NZ_CP026067.1\|WP_031927754.1\|1532939_1534187_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|237507	PRK13790, PRK13790, phosphoribosylamine--glycine ligase; Provisional.	0
NZ_CP026067.1\|WP_001289618.1\|1544044_1544278_-\|glutaredoxin-family-protein	gnl\|CDD\|239274	cd02976, NrdH, NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase activity that is dependent on TRX reductase, not glutathione (GSH). It is part of the NrdHIEF operon, where NrdEF codes for class Ib ribonucleotide reductase (RNR-Ib), an efficient enzyme at low oxygen levels. Under these conditions when GSH is mostly conjugated to spermidine, NrdH can still function and act as a hydrogen donor for RNR-Ib. It has been suggested that the NrdHEF system may be the oldest RNR reducing system, capable of functioning in a microaerophilic environment, where GSH was not yet available. NrdH from Corynebacterium ammoniagenes can form domain-swapped dimers, although it is unknown if this happens in vivo. Domain-swapped dimerization, which results in the blocking of the TRX reductase binding site, could be a mechanism for regulating the oxidation state of the protein.	1.21197e-16
NZ_CP026067.1\|WP_000709282.1\|1531439_1532918_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_CP026067.1\|WP_000437472.1\|1541820_1542087_+\|phosphocarrier-protein-HPr	gnl\|CDD\|237503	PRK13780, PRK13780, phosphocarrier protein HPr; Provisional.	2.44795e-51
NZ_CP026067.1\|WP_047213340.1\|1539832_1541071_+\|class-I-SAM-dependent-rRNA-methyltransferase	gnl\|CDD\|224017	COG1092, COG1092, Predicted SAM-dependent methyltransferases [General function prediction only].	6.42628e-143
NZ_CP026067.1\|WP_000848351.1\|1525252_1525516_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	gnl\|CDD\|224741	COG1828, PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism].	2.06309e-30
NZ_CP026067.1\|WP_000921977.1\|1535251_1536652_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	9.64258e-65
NZ_CP026067.1\|WP_000030808.1\|1529827_1530856_+\|phosphoribosylformylglycinamidine-cyclo-ligase	gnl\|CDD\|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	0
NZ_CP026067.1\|WP_000638453.1\|1545833_1546853_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|224213	COG1294, AppB, Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion].	1.67944e-76
NZ_CP026067.1\|WP_000505962.1\|1541124_1541667_+\|hypothetical-protein	gnl\|CDD\|368297	pfam05128, DUF697, Domain of unknown function (DUF697). Family of bacterial hypothetical proteins that is sometimes associated with GTPase domains.	0.00760449
NZ_CP026067.1\|WP_000666799.1\|1525517_1526189_+\|phosphoribosylformylglycinamidine-synthase-I	gnl\|CDD\|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	1.77638e-140
NZ_CP026067.1\|WP_031927753.1\|1530858_1531425_+\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|223376	COG0299, PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism].	1.64347e-91
NZ_CP026067.1\|WP_031927757.1\|1542089_1543808_+\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
NZ_CP026067.1\|WP_000514290.1\|1546985_1547648_+\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	4.35421e-66
NZ_CP026067.1\|WP_000381852.1\|1544475_1545837_+\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	1.81103e-165
NZ_CP026067.1\|WP_000033477.1\|1536667_1537243_-\|ECF-transporter-S-component	gnl\|CDD\|227065	COG4721, COG4721, ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism].	4.34592e-70

>NZ_CP026067.1|WP_000033477.1|1536667_1537243_-|ECF-transporter-S-component
MSKGLKLSEILVTVLISVVFAVIYNLWWFVYNGVQATGLHLEQLTNGVWFMAAIVCYLIIPKPGIALLAEFAAGAGETIIMGRFDIPTIVYAFIQGLACELVFAIFKYQSRSVMVAMLAGFCTAIAAFPIDYFYGYLNEVAGWNLTLFIVFRLISGAVVAGVLSYLLVKALDKTGVTKLFRPAAKEDYDNL
>NZ_CP026067.1|WP_000921977.1|1535251_1536652_-|ABC-transporter-ATP-binding-protein
MLKVSDLRLKYPSGQRKIFDHLNITIQDKEKVLLLGPSGCGKSTLLNVLSGIVPNLIELPMKYDELIVDPLSGVIFQDPDSQFCMPKVYEELAFVLENRQVPREDMDALIINALNMVNLNVTPETYIKDLSGGMKQKLAIVETILQQSKTLFLDEPTAMLDVQATEDLWTKLIELWENQTVVIVEHKVKHIWNHVDRVILMDYNGNIIADECPEIILQKYVHLLSEYGVWHPRAWEFAPSRVDFPTANSHLLQFKNGRIIRGKSTLLSFSDLEIGLGEWITITGANGSGKTTLLESIMQLIKYQGDVYFENQRLTKIKHAAKHMYLVYQNPELQFITNSVYDEINIHFNHLSKDQSDDETMQLLKLLDLENVKDQHPYELSIGQKRRLSVATALSSKADIIFLDEPTFGLDSHNTFQLIKLFQKRINLGQSIVMVTHDDEIIERYPSRRLKISDGALLDCDGDTNV
>NZ_CP026067.1|WP_000273259.1|1534452_1535259_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MYEQWKVRQSFVDDVNIITKLFLGIILFFFIIFVHNFDFMLYITILMLVFLLMFNGTQFKITAIFITISIGFALLSSLFMILYGNGSHTILKFGFIHITTESLVRGLHVSLRTIAISFFGILIALTSQVVMIFYSLMQHLKVKSKVAYAFMAAIRMIPLMISSLIQLRRSLKMRYQMIDASNYRGLKRFKHLIIPLLSQNIRKAHQLSVAMESKGFRDGPRTYYYNVPFSYKDVIFIIVLIAIITLAYYCSINLPITGIDDVRLGRVG
>NZ_CP026067.1|WP_031927754.1|1532939_1534187_+|phosphoribosylamine--glycine-ligase
MNVLVIGAGGREHALAYKLNQSNLVKQVFVIPGNEAMTPIAEVHTEISESDHQGILDFAKQQDVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQAAQIEGSKLFAKKIMEKYNIPTADYKEVERKKDALTYIENCELPVVVKKDGLAAGKGVIIADTIEAARSAIEIMYGDEEEGTVVFETFLEGEEFSLMTFVNGDLAVPFDCIAQDHKRAFDHDEGPNTGGMGAYCPVPHISDDVLKLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDGPKVIEFNARFGDPEAQVLLSRMESDLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPDAYEKGHKVSGFDLNENYFVSGLKKQGDTFVTSGGRVILAIGKGDNVHDAQRDAYEKVSQIQSDHLFYRHDIANKALQLK
>NZ_CP026067.1|WP_000709282.1|1531439_1532918_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MKKAILSVSNKTGIVEFAKALTQLNYELYSTGGTKRILDEANVPVRSVSDLTHFPEIMDGRVKTLHPAVHGGILADRNKPQHLNELSEQHIDLIDMVVVNLYPFQQTVANPDVTMDEAIENIDIGGPTMLRAAAKNYKHVTTIVHPADYQEVLTRLRNDSLDESYRQSLMIKVFEHTAEYDEAIVRFFKGDKETLRYGENPQQSAYFVRTSNAKHTIAGAKQLHGKQLSYNNIKDADATLALVKKFDTPAAVAVKHMNPCGVGIGDTIEQAFQHAYEADSQSIFGGIVALNRAVTPELAEQLHSIFLEVIIAPKFTDEALDILKQKKNVRLLEIDMTIDSNEEEFVSVSGGYLVQDKDNYVVPKEEMKVVTEVAPTDEQWEAMLLGWKVVPSVKSNAIILSNNKQTVGIGAGQMNRVGAAKIALERAIEINDHVALVSDGFFPMGDTVELAAQHGIKAIIQPGGSIKDQDSIDMANKHGIAMVVTGTRHFKH
>NZ_CP026067.1|WP_031927753.1|1530858_1531425_+|phosphoribosylglycinamide-formyltransferase
MVKIAIFASGSGSNFENIVEHVESGKLENIEVTALYTDHQNAFCIDRAKKHDIPVYINEPKKFDSKAAYEQHLVTLLNEDKVEWIILAGYMRLIGPDLLASFEGKILNIHPSLLPKYKGIDAIGQAYHSGDTITGSTVHYVDSGMDTGEIIEQRQCDIRPDDSKEQLEEKVKKLEYELYPSVIAKIVK
>NZ_CP026067.1|WP_000030808.1|1529827_1530856_+|phosphoribosylformylglycinamidine-cyclo-ligase
MSKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSGTDGVGTKLKLAIDYGKHDSIGIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIVKGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGAVEKDDYVDGSEVEEGQVVIGLASSGIHSNGYSLVRKLINESGIELASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKAMNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGYTVIVDEKDVSRALKILAEQNVEAYQIGHIVKNESTAIELLGV
>NZ_CP026067.1|WP_000032747.1|1526181_1528371_+|phosphoribosylformylglycinamidine-synthase-subunit-PurL
MSKFIEPSVEEIKLEKVYQDMGLSDQEYEKVCDILGRQPNFTETGIFSVMWSEHCSYKHSKPFLKQFPTSGEHVLMGPGEGAGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGIIRDIVSIGARPINLLNSLRFGELDNKQNQRLLKGVVKGIGGYGNCIGIPTTAGEIEFDERYDGNPLVNAMCVGVINHDMIQKGTAKGVGNSVIYVGLKTGRDGIHGATFASEELTEESESKRPSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLHLRLEQVPTREPGISPYEMMLSETQERMLLVVEKGTEQKFLDLFDKHELDSAVIGEVTDTNRFVLTYDDEVYADIPVEPLADEAPVYILEGEEKNYNTSKNDYTHIDVKDTFFKLLKHPTIASKHYLYDQYDQQVGANTIIKPGLQASVVRVEGTNKAIASTIDGEARYVYNNPYEGGKMVVAEAYRNLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMAEACDILKTPVVSGNVSLYNETKGTSIFPTPVVGMVGLIENVNYLNDFEPQVGDKLYLIGDTKDDFGGSQLEKLIYGKVNHEFESLDLSSEVEKGESIKTAIREGVLSHVQTVGKGGLLITLAKLSAHYGLGLKSSIDITNAQLFSETQGRYVVSVKSGKTLNIDNAIEIGLLTDSDNFKVTTPYTEISENVSDIKQIWEGAIAQCLTTQD
>NZ_CP026067.1|WP_000666799.1|1525517_1526189_+|phosphoribosylformylglycinamidine-synthase-I
MKFAVLVFPGSNCDRDMFNAAIKSGVEAEYVDYRETSLSGFDGVLIPGGFSFGDYLRSGAMASVAPIISEVKRLAAEGKPVLGVCNGFQILTEIGLLPGALLHNDSHLFISRNEELEIVNNQTAFTNLYEQGEKVIYPVAHGEGHYYCTDEIYQQLKANNQIILKYVNNPNGSYDDIAGIVNEKGNVCGMMPHPERALETLLGTDSGVKLFEAMVKSWREQHV
>NZ_CP026067.1|WP_000848351.1|1525252_1525516_+|phosphoribosylformylglycinamidine-synthase-subunit-PurS
MKTIELHITLQPQVLDTQGQTLTRAVHDLGYAQVNDIRVGKVLYMTVDEVSDEKVHNIITTLSEKLFANTVIEEYSYKVLEDEKENA
>NZ_CP026067.1|WP_000064214.1|1537826_1537961_-|hypothetical-protein
MSNENQNKKAAEKAKEVEEKLKDKKEEKTEDINQTKQDIQDTLN
>NZ_CP026067.1|WP_000009069.1|1538112_1539408_+|hypothetical-protein
MSFLRKHAEIIFSYLIGIVSLFTGLIILINLPLIKQLNGGKKVDTHVHNVWEFLNAFFSEIIKVMSRFIGNFPIVSAIVIIIFGILVMLIGHTLLRTIKYDYDISIFFLVIGIMYFIITLILMTQVYGFFAVIFIIPFTIHIGYIVYKDELNQENVKNHFMWIIVSYGISYLITQIALYGRIDANEIESIDILSVNAFFIIMWLLGQMAIWNFLFLRRALPLTKQELGEEEPELSRTSKGNVTNQTKIHLKQLQDKTTEYARKTRRSVDLDKIRAKRDKFKKKVNDIIDIQEDDIPDWMRKPKWVKPMYVELFCGVVIFLFTFLEFNNRNALFVSGDWKLSQTQYVIEWVTLLILLFIIIAYIATTLTFHLKGKFYYLQLFMGSILFFKLLTEFINIMIHGLLLSVFITPTLLLMLLAIIISYSLQLRERP
>NZ_CP026067.1|WP_047213340.1|1539832_1541071_+|class-I-SAM-dependent-rRNA-methyltransferase
MKIATLNKGKETKYFNGYPLIEEEDIYSQDHLKEEDIYSQDHLKEEDIYSQDHLKEGDIFQIVTDKSQYVATAYVGRQHKGLGWVLTYDKAQEINTAFFVKLFKTALAERDYYFNIDGTNAFRLFNAEGDGVGGLTIDNYDGHLLIQWYSKGIYKFKYAILEAVRKVFDYKSIYEKVRFKDSEYSGGFVEGDAPEFPIVIEENFTFYNVDLEDGLMTGIFLDQKEVRKKLRDQYAKERHVLNLFSYTGAFSVIAASEASSTTSVDLANRSRSLTEENFGLNAIDPKSQYIYVMDTFDFYKYAARHGHSYDTIVIDPPSFARNKKRTFSVQKDYDKLINGALNILSSEGTLLLCTNASVYPLKQFKNTIKKTLEESGVDYELTEVMGLPKDFKTHPHYKPSKYLKAVFVNIRH
>NZ_CP026067.1|WP_000505962.1|1541124_1541667_+|hypothetical-protein
MGFKNNLTSNLTNKIGNSVFKIENINEKGAMPTTIKELNERRQRAEAIVKRKSLMSSTMSVVPIPGLDFGVDLKLMKDIIEDVNKIYGLDHKQVNSLGDDVKERVMSAAAIQGSQFIGKRISSAFLKIVIRDVAKRTAAKQTKWFPVVGQAVSASISYYFMNKIGKDHIQKCENVIKNVM
>NZ_CP026067.1|WP_000437472.1|1541820_1542087_+|phosphocarrier-protein-HPr
MEQNSYVIIDETGIHARPATMLVQTASKFDSDIQLEYNGKKVNLKSIMGVMSLGVGKDAEITIYADGSDESDAIQAISDVLSKEGLTK
>NZ_CP026067.1|WP_031927757.1|1542089_1543808_+|phosphoenolpyruvate--protein-phosphotransferase
MSKLIKGIAASDGVAIAKAYLLVEPDLTFDKNEKVTDVEGEVAKFNGAIEASKVELTKIRNNAEVQLGADKAAIFDAHLLVLDDPELIQPIQDKIKNENANAATALTDVTTQFVTIFESMDNEYMKERAADIRDVSKRVLSHILGVELPNPSMIDESVVIVGNDLTPSDTAQLNKEFVQGFATNIGGRTSHSAIMSRSLEIPAIVGTKSITQEVKQGDMIIVDGLNGDVIVNPTEDELIAYQDKRERYFADKKELQKLRDADTVTVDGVHAELAANIGTPNDLPGVIENGAQGIGLYRTEFLYMGRDQMPTEEEQFEAYKEVLEAMNGKRVVVRTLDIGGDKELSYLNLPEEMNPFLGYRAIRLCLAQQDIFRPQLRALLRASVYGKLNIMFPMVATINEFREAKAILLEEKENLKNEGHDISDDIELGIMVEIPATAALADVFAKEVDFFSIGTNDLIQYTLAADRMSERVSYLYQPYNPSILRLVKQVIEASHKEGKWTGMCGEMAGDETAIPLLLGLGLDEFSMSATSILKARRQINGLSKNEMTELANRAVDCATQEEVIELVNNYVK
>NZ_CP026067.1|WP_001289618.1|1544044_1544278_-|glutaredoxin-family-protein
MSEIIVYTQNDCPPCTFVKNYLNEHQIDFEERNINNQQYRNEMIDFDAFSTPFILLNGNPMYHVDLDEINKVLNIQD
>NZ_CP026067.1|WP_000381852.1|1544475_1545837_+|cytochrome-ubiquinol-oxidase-subunit-I
MDTVEISRFLTAMTLAVHIIFATIGVGMPLMFAIAEFLGIRKNDLQYIAMAKRWAKAYTITVAVGVVTGTIIGLQLSLIWPTFMEMGGHVIALPLFMETFAFFFEAIFLSIYLYTWDRFKNKWTHFLISIPVIIGGSFSAFFITSVNSFMNTPAGFELKNGKMVNVQPIEAMFNPSFIVRSFHVITTAGMTMAFVIASIAAFKLLRNRQPKDTVYHKKALKMSMIVGFFSTLLSMLAGDLSAKFLHKFQPEKLAAYEWHFDTSSHAKLLLFGVLDEKTQQVKGAIELPGLLSFLADNSVKTKVQGLNDFPKSLHPPMIVHYFFDLMVTMGILCFVISGVYVLTLMFKKLRKFSTHKWMLYGILLTGPASMLAIEFGWFLTEMGRQPWIVRGYMRVAEAATQAGGITFVTILFGVLYIILMYTCAYVLIRMFKNKPAYEDVNRLAKKQGGEIEK
>NZ_CP026067.1|WP_000638453.1|1545833_1546853_+|cytochrome-d-ubiquinol-oxidase-subunit-II
MIYAFIGITVLWLFLFCYIIIASIDFGAGFFALHSKLTGDEKKINHLISRYLNPVWEVTNVFFVFFFVGFVGFFPESIKYLGTVLLIPGSIALIMISLRNSFYAFENYGQDTKLAWMIMYGVSGLLIPASLSTALTITEGGYINVRNNVIDLDWVQLLLSPFAWSVVFLAIISVLYISSGFLTYYAKKANDEPAYNLTRQWHIFLGPPMIIICLFVFLSLRIQNSEHFYSAVFDYWWMFAISFLFFALASLLTFFKKKHGLAFVFVILQMMFAFFGYGISKLPYLLYPFVKITDAYVNPEMGWTLVIVFILGLLLLLPSLILLLRLFVFDKEYVEGKKS
>NZ_CP026067.1|WP_000514290.1|1546985_1547648_+|TrkA-family-potassium-uptake-protein
MGKEYVVIGLGRFGGSIVRELNALDMDVMAIDHDENRVNEYSDIATHAVVADTTDEAVMKSLGIRNFDHVIVAIGENIQSSTLTTLILKELGVKKVTAKAQNDYHAKILNKIGADTVVHPERDMGRRIAHNVASASVLDYLELADEHSIVELKATEKMAGQSIIDLDIRAQYGINIIAIKRGKEFIISPNPNINLEIGDILIMIGHDNDLNRFEKNIATR

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Crispr_ID: NZ_CP026067_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP026067_5

2306458-2306540

Orphan

Consensus_repeat	Method
TGCAAGTTGGGGTGGGGCCCCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP026067_5

>merge|NZ_CP026067|5|2306458-2306540|CRISPRCasFinder
TGCAAGTTGGGGTGGGGCCCCAACACAGAAGGTGACGTAATGTCAACTTACTATAATGTGCAAGTTGGGGTGGGGCCCCAACA

>NZ_CP026067|5|5|2306458-2306540|CRISPRCasFinder
TGCAAGTTGGGGTGGGGCCCCAACA	CAGAAGGTGACGTAATGTCAACTTACTATAATG
TGCAAGTTGGGGTGGGGCCCCAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP026067.1\|WP_047213531.1\|2311177_2312296_-\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NZ_CP026067.1\|WP_000136257.1\|2315542_2316037_-\|thiol-peroxidase	unknown	unknown	gnl\|CDD\|179055
NZ_CP026067.1\|WP_000634175.1\|2312436_2312937_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP026067.1\|WP_047213534.1\|2316134_2316905_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NZ_CP026067.1\|WP_000829167.1\|2292148_2293270_-\|citrate-synthase	unknown	unknown	gnl\|CDD\|184468
NZ_CP026067.1\|WP_000226939.1\|2302021_2305219_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|223660
NZ_CP026067.1\|WP_000818525.1\|2293617_2294979_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP026067.1\|WP_000161654.1\|2309807_2310863_+\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|223085
NZ_CP026067.1\|WP_000123175.1\|2290831_2292100_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|180792
NZ_CP026067.1\|WP_000777192.1\|2308943_2309633_-\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|234811
NZ_CP026067.1\|WP_000160435.1\|2306583_2307882_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226594
NZ_CP026067.1\|WP_000471567.1\|2299288_2300146_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
NZ_CP026067.1\|WP_000277602.1\|2308086_2308500_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP026067.1\|WP_001232650.1\|2295328_2297086_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235784
NZ_CP026067.1\|WP_047213529.1\|2300340_2301570_-\|malate-dehydrogenase	unknown	unknown	gnl\|CDD\|235976
NZ_CP026067.1\|WP_000626082.1\|2305239_2306181_-\|pApA-hydrolase-Pde2	unknown	unknown	gnl\|CDD\|223691
NZ_CP026067.1\|WP_000883646.1\|2298344_2299289_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
NZ_CP026067.1\|WP_000840576.1\|2314472_2315420_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|223897
NZ_CP026067.1\|WP_000717561.1\|2297107_2298076_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NZ_CP026067.1\|WP_047213533.1\|2313182_2314385_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680

Protein	Function_ID	Function_description	E-value
NZ_CP026067.1\|WP_047213531.1\|2311177_2312296_-\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NZ_CP026067.1\|WP_000136257.1\|2315542_2316037_-\|thiol-peroxidase	gnl\|CDD\|179055	PRK00522, tpx, thiol peroxidase.	5.93419e-100
NZ_CP026067.1\|WP_000634175.1\|2312436_2312937_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.27306e-36
NZ_CP026067.1\|WP_047213534.1\|2316134_2316905_-\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	6.72678e-38
NZ_CP026067.1\|WP_000829167.1\|2292148_2293270_-\|citrate-synthase	gnl\|CDD\|184468	PRK14035, PRK14035, citrate synthase; Provisional.	0
NZ_CP026067.1\|WP_000226939.1\|2302021_2305219_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|223660	COG0587, DnaE, DNA polymerase III, alpha subunit [DNA replication, recombination, and repair].	0
NZ_CP026067.1\|WP_000818525.1\|2293617_2294979_+\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NZ_CP026067.1\|WP_000161654.1\|2309807_2310863_+\|aminopeptidase-P-family-protein	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	2.79772e-126
NZ_CP026067.1\|WP_000123175.1\|2290831_2292100_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0
NZ_CP026067.1\|WP_000777192.1\|2308943_2309633_-\|metal-dependent-hydrolase	gnl\|CDD\|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	2.522e-133
NZ_CP026067.1\|WP_000160435.1\|2306583_2307882_-\|CBS-domain-containing-protein	gnl\|CDD\|226594	COG4109, COG4109, Predicted transcriptional regulator containing CBS domains [Transcription].	0
NZ_CP026067.1\|WP_000471567.1\|2299288_2300146_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	0
NZ_CP026067.1\|WP_000277602.1\|2308086_2308500_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.00154e-19
NZ_CP026067.1\|WP_001232650.1\|2295328_2297086_-\|pyruvate-kinase	gnl\|CDD\|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0
NZ_CP026067.1\|WP_047213529.1\|2300340_2301570_-\|malate-dehydrogenase	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
NZ_CP026067.1\|WP_000626082.1\|2305239_2306181_-\|pApA-hydrolase-Pde2	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	9.95606e-99
NZ_CP026067.1\|WP_000883646.1\|2298344_2299289_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
NZ_CP026067.1\|WP_000840576.1\|2314472_2315420_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|223897	COG0827, COG0827, Adenine-specific DNA methylase [DNA replication, recombination, and repair].	3.79172e-57
NZ_CP026067.1\|WP_000717561.1\|2297107_2298076_-\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	0
NZ_CP026067.1\|WP_047213533.1\|2313182_2314385_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0

>NZ_CP026067.1|WP_000626082.1|2305239_2306181_-|pApA-hydrolase-Pde2
MISTLNEIMKCIEDNDTIIIHRHVRPDPDAYGSQLGLKYYIQQKFPQKQVFAVGEAESSLSFIGELDNIDDKTYQDALVIVCDTANAPRIDDERYSTGSKLIKIDHHPAVDQYGDINLVNTNASSTSEIIYDLISHFNDEAIVNKDIASVLYLGIVGDTGRFLFNNTSEHTMEIAGKLIGHDIDHNALLNKMMEKDPKMLPFQGYVLQHFELMDDGFCQVKITEDVLEQFGIQPNEASQFVNTIADIKGLKIWVFAVDEGSEIRCRLRSKGQLIINDIAQDFGGGGHPNASGVSVNSWDEFEQLATALRTKLN
>NZ_CP026067.1|WP_000226939.1|2302021_2305219_-|DNA-polymerase-III-subunit-alpha
MVAYLNIHTAYDLLNSSLKIEDAVRLAVSENVEALAITDTNVLYGFPKFYDACIANNIKPIFGMTIYVTNGLNTIETVVLAKDNNGLKDLYQLSSKIKMNSMENVSFELLQQFSSNLIIIFKNVADEHRDIVQVFDSHEDTYLDHQSVLVQGIKHVWIQNVCYQTRQDADTISALAAIRDNTKLDLIHDQEDFGAHFLTEKEIKQLDINQEYLTQVDVIAQKCNAELKYHQSLLPQYQTPNDESAKKYLWRVLVTQLKKLELNYDVYLERLKYEYKVITNMGFEDYFLIVSDLIHYAKTNDVMVGPGRGSSAGSLVSYLLGITTIDPIKFNLLFERFLNPERVTMPDIDIDFEDTRRERVIQYVQEKYGELHVSGIVTFGHLLARAVARDVGRIMGFDEVTLNEISSLIPHKLGITLDEAYQIDDFKKFVHRNHRHERWFSICKKLEGLPRHTSTHAAGIIINDHPLYEYAPLTKGDTGLLTQWTMTEAERIGLLKIDFLGLRNLSIIHQILTQVKKDLGINIDIEKIPFDNQKVFELLSQGDTTGIFQLESDGVRSVLKKLKPEHFEDIVAVTSLYRPGPMEEIPTYITRRHDPSKVQYLHPHLEPILKNTYGVIIYQEQIMQIASTFANFSYGEADILRRAMSKKNRAVLESERQHFIEGAKQNGYHEDISKQIFDLILKFADYGFPRAHAVSYSKIAYIMSFLKVHYPNYFYANILSNVIGSEKKTAQMIEEAKKQGITILPPNINESHWFYKPSQEGIYLSIGTIKGVGYQSVKVIVDERYQNGKFKDFFDFARRIPKRVKTRKLLEALILVGAFDAFGKTRSTLLQAIDQVLDGDLNIEQDGFLFDILTPKQMYEDKEELPDALISQYEKEYLGFYVSQHPVDKKFVAKQYLTIFKLSNAQNNKPILVQFDKVKQIRTKNGQNMAFVTLNDGIETLDGVIFPNQFKKYEELLSHNDLFIVSGKFDHRKQQRQLIINEIQTLATFEEQKLAFAKQIIIRNKSQIDMFEEMIKATKENANDVVLSFYDETIKQMTTLGYINQKDSMFNNFIQSFNPSDIRLI
>NZ_CP026067.1|WP_047213529.1|2300340_2301570_-|malate-dehydrogenase
MSLRDEALEMHKRNQGKLEVKPNVKVTNKEELSLAYSPGVAEPCKDIYEDKRKVYDYTIKGNTVAVITDGTAVLGLGNIGPEASIPVMEGKAVLFKSFAGINGVPIALNTTDTEEIIKTVKLLEPNYGGINLEDISAPRCFEIEERLKKETNIPVFHDDQHGTAIVTIAGLVNAFRVVNKDIAKIKVVLNGAGAAGIAIVKLLYAYGVRNMVMCDSRGAIFEGRSYGMNPTKDVVAKWTNKDKIEGSLEEVVKDADVFIGVSVANALSQDMVKSMADNPIIFAMANPNPEIIPDDAKAAGARVVGTGRSDYPNQINNVLAFPGIFRGALEVEATHINEEMKKAAVEAIADLIDSSELNEDYCIPGPFDKRVAPSVARNVAKAAMESGVARIEVDPQDVYDKTMKLTDLQ
>NZ_CP026067.1|WP_000471567.1|2299288_2300146_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MFKDFFNRTKKKKYLTVQDSKNNDVPAGIMTKCPKCKKIMYTKELAENLNVCFNCDHHIALTAYKRIEAISDEGSFTEFDKGMTSANPLDFPSYIEKIEKDQQKTGLKEAVVTGTAQLDGMKFGVAVMDSRFRMGSMGSVIGEKICRIIDYCTENRLPFILFSASGGARMQEGIISLMQMGKTSVSLKRHSDAGLLYISYLTHPTTGGVSASFASVGDINLSEPKALIGFAGRRVIEQTINEKLPDDFQTAEFLLEHGQLDKVVHRNDMRQTLSEILKIHQEVTK
>NZ_CP026067.1|WP_000883646.1|2298344_2299289_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDIEQQALAIKSAFVEQLDSLESLSRDEIANDRFEKFRNIGSYIE
>NZ_CP026067.1|WP_000717561.1|2297107_2298076_-|6-phosphofructokinase
MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
>NZ_CP026067.1|WP_001232650.1|2295328_2297086_-|pyruvate-kinase
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIAEILEVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVTNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQGIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
>NZ_CP026067.1|WP_000818525.1|2293617_2294979_+|amino-acid-permease
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTYIGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGLIVVGFVMILFAFKTQFGHASFTNLYEHGIFAKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRILIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFSKTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKNATYKLLGGKYMGYLIFVFFIFVFGLLFINVDTRRAIYFIPIWFILLAFMYLRYKRIAAKSNK
>NZ_CP026067.1|WP_000829167.1|2292148_2293270_-|citrate-synthase
MAELQRGLEGVIAAETKISSIIESQLTYAGYDIDDLAENAQFEEVIFLLWNYRLPNEEELAHLKGKLNQYMTLNPRVYTHFEEYVTDHVHPMTALRTSLSYIAHFDPDAENESDENRYERAMRIQAKVASLVTAFARVRQDKEPLKPNPDLSYAANFLYMLRGELPTDIEVEAFNKALILHADHELNASAFTARCAVSSLSDMYSGIVAAVGSLKGPLHGGANEQVMTMLSEIGSIENVDAYLDEKFANKDKVMGFGHRVYKDGDPRAKYLREMSRQITKDAGREELFEMSVKMEKRMAEEKGLIPNVDFYSASVYHCMEIPHDLFTPIFAVSRSAGWIAHILEQYKDNRIMRPRAKYIGETNRKYIPLEERK
>NZ_CP026067.1|WP_000123175.1|2290831_2292100_-|NADP-dependent-isocitrate-dehydrogenase
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK
>NZ_CP026067.1|WP_000160435.1|2306583_2307882_-|CBS-domain-containing-protein
MTKHEQILDYIESLSIGSKISVRKIAKFLNVSEGTAYRAIKDADKMGMVATIDRVGTVRIEKRNRNEIEHLTFNEIVNIIDGQVLGGNKGITKMVSKFAIGAMELKDILKYIGPKTLLIVGNREDVQIEALKRGTAILITGGFKPSNKVINFANEHDLPVLSSSYDTFLVANIINKALFNQKIRKDILIVQDIMTPLDDLSVLFDTMKIADYKRMANRTGHTRFPVVNESYKLVGIVTSREMINTKDDDEIDKVMTRNPIYVNAMSTVASCAHMMIWEGIELIPVVSSNKKTVGVINRQDVLKSMQLLGRQPQMGETINDQIAKYITMNQDGITVEVSPLLINHYGTVSKAAFVSIIEETIQYEMRKFKKGNVMIENLNIVYIKTVPIESHITVRFGILDVGRNFAKIEVNMHSQNDKVASALVICQMFDEV
>NZ_CP026067.1|WP_000277602.1|2308086_2308500_+|universal-stress-protein
MYKNILLGVDTQLKNEKALKEVSKLAGEGTVVTVLNAISEQDAQASIKAGVHLNKLTEERSKRLEKTRKALEDYGIDYDQIIVRGNAKEELLKHANSGKYEIVVLSNRKAEDKKKFVLGSVSHKVAKRATIPVLIVK
>NZ_CP026067.1|WP_000777192.1|2308943_2309633_-|metal-dependent-hydrolase
MKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKNTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF
>NZ_CP026067.1|WP_000161654.1|2309807_2310863_+|aminopeptidase-P-family-protein
MTKISKIIDELNNQQADAAWITTPLNVYYFTGYRSEPHERLFALLIKKDGKQVLFCPKMEVEEVKASPFTGEIVGYLDTENPFSLYPQTINKLLIESEHLTVARQKQLISGFNVNSFGDIDLTIKQLRNIKSEDEISKIRKAAELADKCIEIGVSYLKEGVTEREVVNHIEQTIKQYGVNEMSFDTMVLFGDHAASPHGTPGDRRLKSNEYVLFDLGVIYEHYCSDMTRTIKFGEPNKEAQEIYNIVLEAETSAIQAIKPGIPLKDIDHIARNIISEKGYGEYFPHRLGHGLGLQEHEYQDVSSTNSNLLEAGMVITIEPGIYVPGVAGVRIEDDILVTNEGFEVLTHYEK
>NZ_CP026067.1|WP_047213531.1|2311177_2312296_-|alanine-dehydrogenase
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEDKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKASRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
>NZ_CP026067.1|WP_000634175.1|2312436_2312937_+|universal-stress-protein
MITYKNILIAVDGSHEAEWAFNRAVGVAKRNDAKLTIVNVIDSRTYSSYEVYDAQFTEKSKHFAEELLNGYKEVATNAGVKDVETRLEFGSPKSIIPKKLAHEINADLIMSGTSGLNAVERFIVGSVSESIVRHAPCDVLVVRTEELPADFQPQVATTQLREKYQN
>NZ_CP026067.1|WP_047213533.1|2313182_2314385_-|acetate-kinase
MSKLILAINAGSSSLKFQLIRMPEEELVTKGLVERIGLKDSIFTIEVNGEKVKTVQDIKDHVEAVDIMLDAFKAHNIINDINDIDGTGHRVVHGGEKFPESVAITDEVEKEIEELSELAPLHNPANLMGIRAFRKLLPNIPHVAIFDTAFHQTMPEKAYLYSLPYHYYKDYGIRKYGFHGTSHKFVSQRAAEMLDKPIEDLRIISCHIGNGASIAAIDGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPFIMEKTGKTAEQVLEILNKESGLLGLSGTSSDLRDLSEEAESGKARSQMALDVFASKIHKYIGSYAARMHGVDVIVFTAGIGENSVEIRAKVLEGLEFMGVYWDPKKNENLLRGKEGFINYTHSPVKVVVIPTDEESMIARDVMTFGGLK
>NZ_CP026067.1|WP_000840576.1|2314472_2315420_-|class-I-SAM-dependent-methyltransferase
MAEQQTIMERLFHTLDEKAKTLNNENGQSFIENLGLAMEQVYTNERGLLEQSTLQDRRKAFQFAYLSLMQEEKIQANHQITPDSIGLILGFLVERFMNNQEELHIVDIASGAGHLSATVKEVLPEIAVMHHLIEVDPVLSRVSVHLANFLEIPFDVYPQDAIMPLPLEEADIVIGDFPVGYYPIDERSKEFKLGFEEGHSYSHYLLIEQAINALKDAGYAFLVVPSNIFTGEHVKQLEKYIATETEMQAFLNLPPTLFKNEKARKSILILQKKKSGETKPVEVLLANIPDFKNPSQFQGFMTELNQWMDTNRPKK
>NZ_CP026067.1|WP_000136257.1|2315542_2316037_-|thiol-peroxidase
MTEITFKGGPIHLKGQQINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSEASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI
>NZ_CP026067.1|WP_047213534.1|2316134_2316905_-|TSUP-family-transporter
MDLNLTMIIIIILFGFIAAFIDSVVGGGGLISTPALLAIGLPPSVALGTNKLASSFGSLTSTIKFIRSGKVDLYVVAKLFGFVFLASACGAYIATMVPSQILKPLIIIALSSVFIFTLLKKDWGNTRTFTQFTFKKAILFAALFILIGFYDGFVGGGTGSFMLFVLLVFGFDFLSAAGNAKVLNFASNIGALVLFMVLGQVDYVIGLIMASSMIAGSYTGAHFAIKQGVGYVKVLFIIITAILILKNAFDYIQQFL

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Crispr_ID: NZ_CP026067_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP026067_6

2621185-2621264

Orphan

Consensus_repeat	Method
GGCCCCACCCCAACTTACATTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP026067_6

>merge|NZ_CP026067|6|2621185-2621264|CRISPRCasFinder
GGCCCCACCCCAACTTACATTGTTTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCCACCCCAACTTGCATTGT

>NZ_CP026067|6|6|2621185-2621264|CRISPRCasFinder
GGCCCCACCCCAACTTACATTGT	TTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGG
GGCCCCACCCCAACTTGCATTGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP026067.1\|WP_001045081.1\|2621404_2622712_+\|TrkH-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|273349
NZ_CP026067.1\|WP_047213639.1\|2614448_2615465_-\|bi-component-leukocidin-LukGH-subunit-G	unknown	unknown	gnl\|CDD\|369625
NZ_CP026067.1\|WP_000172943.1\|2629442_2630534_+\|replication-initiation-factor-domain-containing-protein	unknown	unknown	gnl\|CDD\|367101
NZ_CP026067.1\|WP_001049399.1\|2611091_2611247_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_001108473.1\|2618698_2619568_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP026067.1\|WP_000134547.1\|2628196_2628481_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_001035611.1\|2625744_2626296_+\|DUF4888-domain-containing-protein	unknown	unknown	gnl\|CDD\|294014
NZ_CP026067.1\|WP_000201394.1\|2623906_2624086_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_000323493.1\|2627140_2628082_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_000386892.1\|2628965_2629268_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_031927406.1\|2619570_2620773_-\|5-aminolevulinate-synthase	unknown	unknown	gnl\|CDD\|236370
NZ_CP026067.1\|WP_001089804.1\|2611233_2611419_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_000805733.1\|2628631_2628952_+\|DUF961-family-protein	unknown	unknown	gnl\|CDD\|368761
NZ_CP026067.1\|WP_000705240.1\|2611618_2611801_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_047213641.1\|2623283_2623910_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_000206632.1\|2616977_2618201_+\|ArgE/DapE-family-deacylase	unknown	unknown	gnl\|CDD\|181490
NZ_CP026067.1\|WP_000791409.1\|2615486_2616542_-\|bi-component-leukocidin-LukGH-subunit-H	unknown	unknown	gnl\|CDD\|369625
NZ_CP026067.1\|WP_000692002.1\|2630594_2631650_+\|conjugal-transfer-protein	unknown	unknown	gnl\|CDD\|372237
NZ_CP026067.1\|WP_103225775.1\|2612394_2613962_+\|IS3-like-element-ISSau2-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP026067.1\|WP_001013104.1\|2611836_2611983_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP026067.1\|WP_001045081.1\|2621404_2622712_+\|TrkH-family-potassium-uptake-protein	gnl\|CDD\|273349	TIGR00933, Trk_system_potassium_uptake_protein_trkH., potassium uptake protein, TrkH family. The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds].	9.80292e-81
NZ_CP026067.1\|WP_000692002.1\|2630594_2631650_+\|conjugal-transfer-protein	gnl\|CDD\|372237	pfam12642, TpcC, Conjugative transposon protein TcpC. This family of proteins are annotated as conjugative transposon protein TcpC. The transfer clostridial plasmid (tcp) locus is part of some conjugative antibiotic resistance and virulence plasmids. TcpC was one of five genes whose products had low-level sequence identity to Tn916 proteins, having similarity to ORF13 homologs from Tn916, Tn5397, and CW459tet. This family of proteins is found in bacteria. Proteins in this family are typically between 302 and 351 amino acids in length.	5.65329e-22
NZ_CP026067.1\|WP_000805733.1\|2628631_2628952_+\|DUF961-family-protein	gnl\|CDD\|368761	pfam06125, DUF961, Bacterial protein of unknown function (DUF961). This family consists of several hypothetical bacterial proteins of unknown function.	2.35002e-08
NZ_CP026067.1\|WP_001108473.1\|2618698_2619568_-\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.86916e-09
NZ_CP026067.1\|WP_047213639.1\|2614448_2615465_-\|bi-component-leukocidin-LukGH-subunit-G	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	7.62134e-98
NZ_CP026067.1\|WP_000172943.1\|2629442_2630534_+\|replication-initiation-factor-domain-containing-protein	gnl\|CDD\|367101	pfam02486, Rep_trans, Replication initiation factor. Plasmid replication is initiated by the replication initiation factor (REP). This family represents a probable topoisomerase that makes a sequence-specific single-stranded nick in the plasmid DNA at the origin of replication. Human proteins also belong to this family, including myelin transcription factor 2 and cerebrin-50.	1.53969e-53
NZ_CP026067.1\|WP_001035611.1\|2625744_2626296_+\|DUF4888-domain-containing-protein	gnl\|CDD\|294014	cd15783, SA1633_like, Uncharacterized protein family conserved in Staphylococci. Some proteins in this family have been described as putative beta-lactamases. They are structurally similar to the C-terminal beta-grasp domains of Staphylococcal and Streptococcal superantigens.	4.01665e-47
NZ_CP026067.1\|WP_031927406.1\|2619570_2620773_-\|5-aminolevulinate-synthase	gnl\|CDD\|236370	PRK09064, PRK09064, 5-aminolevulinate synthase; Validated.	0
NZ_CP026067.1\|WP_000791409.1\|2615486_2616542_-\|bi-component-leukocidin-LukGH-subunit-H	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	1.31423e-77
NZ_CP026067.1\|WP_103225775.1\|2612394_2613962_+\|IS3-like-element-ISSau2-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	6.32114e-44
NZ_CP026067.1\|WP_000206632.1\|2616977_2618201_+\|ArgE/DapE-family-deacylase	gnl\|CDD\|181490	PRK08588, PRK08588, succinyl-diaminopimelate desuccinylase; Reviewed.	0

>NZ_CP026067.1|WP_031927406.1|2619570_2620773_-|5-aminolevulinate-synthase
MYKTLFFDKIAELKEKGSYRIFTEINRIANKYPLAKGEDGKEVVVFCSNDYLGMSQNQEVINVMSDALKEYGAGAGGSRNIGGSHKYFKLLENEIAKWHKKDSALVFPTGYSSNDAALQGLLRIFPEMIVFSDSKNHASIINALRSVKNKIEIFEHNNVKHLNELLNQYDINIPKLIVFESVYSMDGDIAPIVEIVELAKEYNSLTFLDEVHAIGMYGEEGRGYSDVVGVQEDIDIIQSTMAKGIGIIGGYITGDQLLIDVIRSYSSGFIFTTALPPVIAAGCLTSIKIVRSNDKLREELQDKTKYLKEKFKENGIEVLKQSKTHILPVIIGDSKKCEEAAKLLLDKFNIYVQAINSPTVEIGTERFRINVTPNHTKEQMDLLVSSIVYVFDFLNIRRSV
>NZ_CP026067.1|WP_001108473.1|2618698_2619568_-|DMT-family-transporter
MNYLMYLFCMFIWGLNFIAVKIQGDSLPLEVALLYRSLIAFSLFGVMFIFIFKKLKLNNTNWFTIIGFGLCNFTISYLLLYYGTFYSSAAIVTLIFSMKAILTPIFISMVFKRKISNRIYIGGGLGVVSVVVILYPDLNSLTNEFIIGVAFALLGTIITSIGDVLSLYNSESKVHPVLSNTIGMLSAVIFLLIYTSFKGYRYSFPLELNFWFGLLYLSILASFLAWFFYLKLINNIGAAESGYMVAMFPAIGGIASVIMGETHLSINLVVGIILACMGAYLALYKPKPS
>NZ_CP026067.1|WP_000206632.1|2616977_2618201_+|ArgE/DapE-family-deacylase
MTTFSEKEKIQLLADIVELQTENNNEIDVCNYLKDLFDKYDIKSEILKVNEHRANIVAEIGNGSPILALSGHMDVVDAGNQDNWTYPPFQLTEKDGKLYGRGTTDMKGGLMALVITLIELKEQNQLPQGTIRLLATAGEEKEQEGAKLLADKGYLDDVDGLIIAEPTGSGIYYAHKGSMSCKVTATGKAVHSSVPFIGDNAIDTLLEFYNQFKEKYSELKKHDTKHELDVAPMFKSLIGKEISEEDANYASGLTAVCSIINGGKQFNSVPDEASLEFNVRPVPEYDNDFIESFFQNIINNVNSNKLSLDIPSNHRPVTSDKNSKLITTIKDVASSYVNKDDIFVSALVGATDASSFLGDNKDNVDLAIFGPGNPLMAHQIDEYIEKDMYLKYIDIFKEASIQYLKEK
>NZ_CP026067.1|WP_000791409.1|2615486_2616542_-|bi-component-leukocidin-LukGH-subunit-H
MKNKKRVLIASSLSCAILLLSAATTQANSAHKDSQDQNKKEHVDKSQQKDKRNVTNKDKNSTVPDDIGKNGKITKRTETVYDEKTNILQNLQFDFIDDPTYDKNVLLVKKQGSIHSNLKFESHKEEKNSNWLKYPSEYHVDFQVKRNPKTEILDQLPKNKISTAKVDSTFSYSSGGKFDSTKGIGRTSSNSYSKTISYNQQNYDTIASGKNNNWHVHWSVIANDLKYGGEVKNRNDELLFYRNTRIATVENPELSFASKYRYPALVRSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQDILKNRPGIHYAPPILEKNKDGQRLIVTYEVDWKNKTVKVVDKYSDDNKPYKEG
>NZ_CP026067.1|WP_047213639.1|2614448_2615465_-|bi-component-leukocidin-LukGH-subunit-G
MIKQLYKNITICSLAISTALTVFPATSYAKINSEIKAVSEKNLDGDTKMYTRTATTSDSQKNITQSLQFNFLTESNYDKETVFIKAKGTIGSGLRILEPNGYWNSTLRWPGSYSVSIQNVDDNNNTNVTDFAPKNQDESREVKYTYGYKTGGDFSINRGGLTGNITKESNYSETISYQQPSYRTLLDQSTSHKGVGWKVEAHLINNMGHDHTRQLTNDSDNRTKSEIFSLTRNGNLWAKDNFTPKDKMPVTVSEGFNPEFLAVMSHDKKDKGKSQFVVHYKRSMDEFKIDWNRHGFWGYWSGENHVDKKEEKLSALYEVDWKTHDVKFVKVLNDNEKK
>NZ_CP026067.1|WP_103225775.1|2612394_2613962_+|IS3-like-element-ISSau2-family-transposase
MKTLKGALFMSIKPKVDIDVLLYMFQEYEKGVSFQYLIDTLQLDINVNTLYPKYKYYKTHGIETLLTQKQYNHYSKELKLKVVNEYLNSNQSTQDLAIKYNIRSSTQVKNWIKMYTVGKEIKNQSPKTGVYIMKARKTTFEERVTIVEYYLNHKQSYREVAEHFNISYGQIYQWVQKYQAHGKNGLVDGRGKGKPKSMMTPEEQKEAEIQALKAQNRLLEMENDVFKKVSSIGKRDDSKRKQITAYKTIEALKHQYPIQRLCRILGISRASYYKWVHYQSSELELENEQLKREIESIYHKYNGIYGYRRIYIYIRLKLGKQVNRKRIYRLMKELNLKAVIRQKRKPYRRSTPQITSENKLNRQFDIDTPNKVWLTDVTEFKIKEGSKIYLSAIYDLGVKRIVSYKLGPSNNNQLVFKTFNQAIEKVENTKGILFHSDRGFQYTSKTFKHMLDECGMIQSMSRVSKCIDNGPMEGVWGTIKSEIFRGNKHFKFNSVEEATKTIHDFILFFNHERITLKMADSV
>NZ_CP026067.1|WP_001013104.1|2611836_2611983_+|hypothetical-protein
MNGGENFMADKNKKQEATRSNPINKSFEKPGASENLKSTLSEKAKKKD
>NZ_CP026067.1|WP_000705240.1|2611618_2611801_+|hypothetical-protein
MKITNCKIKKETIVYEVLTSGNQPFTYELPKDLSSHNARKYLEFISQKIDGDKLTKEDSL
>NZ_CP026067.1|WP_001089804.1|2611233_2611419_+|hypothetical-protein
MNSYKEIEHLHINTGGKELTQEQIEEAKSFIDSQGFKDMIREAKESRQRVMESKITDRTKM
>NZ_CP026067.1|WP_001049399.1|2611091_2611247_+|hypothetical-protein
MNLKEVDINIEEWEMVEIPFYTEEELTYRLKNDLPITKSEFEEQESKNEFL
>NZ_CP026067.1|WP_001045081.1|2621404_2622712_+|TrkH-family-potassium-uptake-protein
MNKVHKPLYFYLMLFFSTTIIGALLLYLPFTGKKPISFLDALFIASSAFTVTGLSPVDIGSQFNILGEIVILLLIQIGGLGIVTVTLLTLVFLNRKISMKNRFLIMVTWNIDEPGGVIKLIKHLAIYSLVTELIGMICLCLSFIPKFGIGKGLFLSLFTSVSAFNNAGFALFKNNLIDYSSDPIVIITISILIIFGGIGHFVVIDFINCKKLSKLSLHSKLVLTTTSILIIIGAITFFLLEQFNTMQNMGLVEKIGNSFFQSVTTRTAGFNSIDIASINKSTALMLMLLMFIGGAPLSASGGIKITTFAVAFIFVLNYIRKENNVSVFNKEISDKHIKLSIVTINISFLFISIITFILSIINPNISLIKLLFEVVSAFGTVGLSMNLTTEYHGITKIIIIFVMLCGKVGLLTLLRTFIPPKSPKNYRYTKGQIYL
>NZ_CP026067.1|WP_047213641.1|2623283_2623910_-|hypothetical-protein
MTVKVISLSELLTGDKQEVKRKIPSVLNILNSFETISISGSESAHDVDLFLKNKSIAFDRQNLSRTHLVFSQFKSKQILVGYFTISNKPLVFTKRMLDKISNTLKKKLYQKGKTHSGNDNLIIQGYLIAQIGKNYSEEALATKSINGNDLLTLAYEKVLEGANIFGGSYIWIDYEDVDRLREFYRKFGFTEIKDHTSENNLKMAILKI
>NZ_CP026067.1|WP_000201394.1|2623906_2624086_-|hypothetical-protein
MATISITTDYKFTKKSAQKLIDAMEINENKSNVNKTNIKATKIKSTCEIENLLKDYRSN
>NZ_CP026067.1|WP_001035611.1|2625744_2626296_+|DUF4888-domain-containing-protein
MNKKLLTKTLIASALVLTTVGSGFHSSSNYNGINNVAKAAETTDGQLWKDVRDSLKEANIIDKSDNENVKVTYKIENGGENTVSGTASLDSLSTNQNINAEITKIEIERKNPNYSNINTDEAWKKLTKSLKEKNLVKNGAKVSIYSKDPSDITITGKVGDSNSNAINRIINPKDITHITVENN
>NZ_CP026067.1|WP_000323493.1|2627140_2628082_-|hypothetical-protein
MAYITTTRWLDNEEQDLDIIIQKLLDVSELNENINTDLKTYHYNFKTYKVFTENKEIELGSQKIEFNTIHFSYDSVRSGDEPLEDRTTNNTGFVLVYFMNSSVKYIINKNTDSQYFLRRFLKYTGQNEITKINLNFNDDLLLWIVYKIYKEISDFIITTNTQSEEHLTFDNIKGFKGDTPDNNKVSSHGNTVLNLISTLSFVLEKGKLGQIILCLSYTNHENIELRLSGSDLVGIDFKRYDGIYEHEECEELFKAKLLLLVYLKIIPNINSFYQSDLNEKKWTDEVKINFLEDIKNEIINRIDLKKETISENN
>NZ_CP026067.1|WP_000134547.1|2628196_2628481_+|hypothetical-protein
MTEFTPFFDGSNQLNYRKFVILRFHGVSKRKICKMYNFAYFRILEVCEMAKKNDYRFTYKDYKFLKQYGVSNTFICKMYHISIEDLEFFEVMNR
>NZ_CP026067.1|WP_000805733.1|2628631_2628952_+|DUF961-family-protein
MKPVLDIKKTLGQLNFLGVDEKYKYENGERTDKTVYAYKLASQEQGEQITVKTPNKVELDYLQECELVEPDVKMYVQMSGDFGTIAYSWNAEDIKVVGSNSALKQK
>NZ_CP026067.1|WP_000386892.1|2628965_2629268_+|hypothetical-protein
MDYYTADRLYRYTNSSNLSEPILNYVASRINWGDKVSLMTLAKEIQSKFNDSYVKENTVKGRPKIYADLCLLCMSLSEAGHGRMLQVNLEDCIYIGDIGV
>NZ_CP026067.1|WP_000172943.1|2629442_2630534_+|replication-initiation-factor-domain-containing-protein
MTLKNQCTPLTNRGVERTNKSAVEAVVDWVQVTFHITPISAVIEDVIGLPITLFKKRNSGIYFYNRGYEFSNIKLYYSSDDESMGIHLQLTGTGCREFEHHLQQLNKTWQDFFDKCLSVNANFTRIDIAIDDYKTYLKVPLLIKKAEKAECVSRFRAGSAINGFNLSDGRSKGATFYIGSKQSNLYCRFYEKNYEQAFKRHCDVEDIGLWNRYEIQMRKAYAVNCAKVLSRTDNISEIVKSILHNNLRFISPPKDGNDKNRKRWPLYRPWALFIKDTEKLNLTTRPTLKSIEDNLDWLCKQVATTLDTVLTAESMAQSEGLLTDTDFLDKILAHSQFNDEHTNRINHYLEALKQKKHLSKDKC
>NZ_CP026067.1|WP_000692002.1|2630594_2631650_+|conjugal-transfer-protein
MKIISKYILTRFSKNGKHFDIPKEQRRVIPKFKNRRKMIVICFYSLLAILLILLLASFIKATRANNDSKEAVNKTNMIQKKYEDNANTVQYSPKLKLYADKFIDTYMNISKDSKELESREKELLKYFPSDYKKPDEKISDTERKLNSKEFYNIKRKDKQTIIQYIVNYDVNITEKKEVKVKKKKKSEKDKDEYETKTEEKQRKVNQNILINIPIKSENNKYVVVEYPYFTPIPDSQLNKAKMVEDNLKDNKREDNPKAKAFIEDFFNKYASSKSDDMAYLMDNPEGLEGTREVSQIREIRLYPKGDDYVAKVEILMKDKDSPLENLEHYTLDITKKDGKYYVKNMTNSIGG

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Crispr_ID: NZ_CP026067_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP026067_7

2777803-2777888

Orphan

Consensus_repeat	Method
CAACTTTAGTTGTTAGGGGCTCTTATGCA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP026067_7

>merge|NZ_CP026067|7|2777803-2777888|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTATTTTTCAACTTTAGTTGTTAGGGGCTCTTATGCA

>NZ_CP026067|7|7|2777803-2777888|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCA	TGCGCTTAGCGCAGGCGCTCCTATTTTT
CAACTTTAGTTGTTAGGGGCTCTTATGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP026067.1\|WP_047213691.1\|2791280_2798714_-\|DUF1542-domain-containing-protein	unknown	unknown	gnl\|CDD\|275089
NZ_CP026067.1\|WP_001802298.1\|2778291_2778396_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_000808822.1\|2772675_2772906_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_000370936.1\|2781279_2782137_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NZ_CP026067.1\|WP_047213687.1\|2779103_2780231_-\|SAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|366887
NZ_CP026067.1\|WP_000927349.1\|2787277_2789410_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CP026067.1\|WP_000083812.1\|2785704_2787243_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NZ_CP026067.1\|WP_001123308.1\|2769757_2770171_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NZ_CP026067.1\|WP_001292149.1\|2789421_2789856_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NZ_CP026067.1\|WP_000123394.1\|2770628_2772002_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NZ_CP026067.1\|WP_047213683.1\|2772936_2773875_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NZ_CP026067.1\|WP_000003759.1\|2775126_2775447_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP026067.1\|WP_001024091.1\|2774309_2774975_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NZ_CP026067.1\|WP_031927658.1\|2783218_2785024_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP026067.1\|WP_000070865.1\|2769114_2769558_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NZ_CP026067.1\|WP_047213685.1\|2776694_2777786_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP026067.1\|WP_000019739.1\|2775448_2776429_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NZ_CP026067.1\|WP_000908193.1\|2782204_2782987_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NZ_CP026067.1\|WP_000648717.1\|2789855_2790962_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NZ_CP026067.1\|WP_000160304.1\|2768283_2768994_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275

Protein	Function_ID	Function_description	E-value
NZ_CP026067.1\|WP_047213691.1\|2791280_2798714_-\|DUF1542-domain-containing-protein	gnl\|CDD\|275089	TIGR04263, cell_wall_surface_anchor_family_protein, SasC/Mrp/FmtB intercellular aggregation domain. This domain, about 375 amino acids long on average, occurs only in Staphylococcus and Streptococcus. It occurs as a non-repetitive N-terminal domain of LPXTG-anchored surface proteins, including SasC, Mrp, and FmtB. This region in SasC was shown to be involved in cell aggregation and biofilm formation, which may explain the methicillin resistance seen for Mrp and FmtB.	1.37143e-108
NZ_CP026067.1\|WP_000648717.1\|2789855_2790962_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NZ_CP026067.1\|WP_000370936.1\|2781279_2782137_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	2.43638e-59
NZ_CP026067.1\|WP_000927349.1\|2787277_2789410_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	5.9991e-68
NZ_CP026067.1\|WP_000083812.1\|2785704_2787243_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NZ_CP026067.1\|WP_000019739.1\|2775448_2776429_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	8.62765e-109
NZ_CP026067.1\|WP_001123308.1\|2769757_2770171_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	2.52292e-44
NZ_CP026067.1\|WP_001292149.1\|2789421_2789856_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
NZ_CP026067.1\|WP_000123394.1\|2770628_2772002_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.92966e-06
NZ_CP026067.1\|WP_047213683.1\|2772936_2773875_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	1.46752e-128
NZ_CP026067.1\|WP_000003759.1\|2775126_2775447_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
NZ_CP026067.1\|WP_001024091.1\|2774309_2774975_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.86209e-48
NZ_CP026067.1\|WP_031927658.1\|2783218_2785024_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP026067.1\|WP_000070865.1\|2769114_2769558_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	5.87929e-68
NZ_CP026067.1\|WP_000160304.1\|2768283_2768994_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
NZ_CP026067.1\|WP_000908193.1\|2782204_2782987_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.56485e-106
NZ_CP026067.1\|WP_047213687.1\|2779103_2780231_-\|SAP-domain-containing-protein	gnl\|CDD\|366887	pfam02037, SAP, SAP domain. The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.	5.97077e-06

>NZ_CP026067.1|WP_047213685.1|2776694_2777786_+|hypothetical-protein
MFTYFKSALKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQNIVIYSQFGQKPPGDVYLKVIAVLLIAAIVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGIYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKDNKVVTEPKNTKVETDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NZ_CP026067.1|WP_000019739.1|2775448_2776429_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNATATKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHVH
>NZ_CP026067.1|WP_000003759.1|2775126_2775447_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NZ_CP026067.1|WP_001024091.1|2774309_2774975_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSIIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFEGKGEIPREDVATVLKEIVTSNHFNHQEFQVISGEQDIKDALTQFENETD
>NZ_CP026067.1|WP_047213683.1|2772936_2773875_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGKSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQRGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYA
>NZ_CP026067.1|WP_000808822.1|2772675_2772906_-|hypothetical-protein
MKQFLYIALVCSVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>NZ_CP026067.1|WP_000123394.1|2770628_2772002_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQINAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NZ_CP026067.1|WP_001123308.1|2769757_2770171_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIQLITSLPNRTKLLGIGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NZ_CP026067.1|WP_000070865.1|2769114_2769558_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLEKAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NZ_CP026067.1|WP_000160304.1|2768283_2768994_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NZ_CP026067.1|WP_001802298.1|2778291_2778396_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NZ_CP026067.1|WP_047213687.1|2779103_2780231_-|SAP-domain-containing-protein
MSVNARDLLVLHNNVNRLVGEEIFANKCLANNDVQIMNSIKKLIEAELLTTTNDFEVSIYKKTRPELQSILKSFGIKTTGNKPDLIKRIDDNFHIINNLDLPYVYIPTKKGEEILKKTEYLTSFIYSYKISLERAYYMVENYIDENCDDKVAEIYKFEFQRKYDNGEFDFNHGYNFELNMLIDHYKRDVKDYDNARKYSNFYLYFGLRDFLKKLMSNYSYYDSKGNIDLNEIQNDLNRFINSSASGMYERLIYNENLSNNIMFELFKKDTQDYSDLEEQLIEKFINYVVSYVKKESRSNTLIELSKMLEKGYTIDKEKFKKEDEYLSRYIITDINYLKNLESKIGVAIDSRNGEIHLVLDDDSLDKLIKNQKNRQ
>NZ_CP026067.1|WP_000370936.1|2781279_2782137_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLREKGYKVFLATGRSHSEIHQLVPEDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NZ_CP026067.1|WP_000908193.1|2782204_2782987_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINGGDKWILYGLNGAGKTTLLNILNVYEPPTTGDVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEIRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NZ_CP026067.1|WP_031927658.1|2783218_2785024_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKSEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>NZ_CP026067.1|WP_000083812.1|2785704_2787243_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIVGFKVLAPIMKFIMYILSVAVESLVHAHLLPVVSILVEPAKILFLNNAINHGVFTPLGTDQAAKVGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKTPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NZ_CP026067.1|WP_000927349.1|2787277_2789410_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGEDSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVKKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHIETKDIDGNTSFENEQTSNLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLALPSIQNDNQTIKYMISMFIPDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NZ_CP026067.1|WP_001292149.1|2789421_2789856_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
>NZ_CP026067.1|WP_000648717.1|2789855_2790962_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFADKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKVFLSEYAKVDDGLADEIIEAYNSLS
>NZ_CP026067.1|WP_047213691.1|2791280_2798714_-|DUF1542-domain-containing-protein
MNLFRQQKFSIRKFNVGIFSALIATVTFISTNPTTASAAEQNQPAQNQPAQPADANTQPNANAGAQANPTAQPAAPANQGQPAAQPANQGGQANPAGGAAQPNTQPAGQGNQADPNNAAQAQPGNQAAPANQAGQGNNQATPNNNATPANQTQPANAPAAAQPAANAQTQDPNASNTGEGSINTTLTFDDPAISTDENRQDPTVTVTDKVNGYSLINNGKIGFVNSELRRSDMFDKNNPQNYQARGNVAALGRVNANDSTDHGNFNGISKTVNVKPDSELIINFTTMQTNSKQGATNLVIKDAKKNTELATVNVAKTGTAHLFKVPTDADRLDLQFIPDNTAVADASRITTNKDGYKYYSFIDNVGLFSGSHLYVKNRDLAPKATNNKEFTINTEIGNNGNFGASLKADQFKYEVTLPQGVTYVNDSLTTTFPNGNEDSTVLKNMTVNYDQNANKVTFTSQGVTTARGTHTKEVLFPDKSLKLSYKVNVANIDTPKNIDFNEKLTYRTASDVVINNAQPEVTLTADPFSVAVEMNKDALQQQVNSQVDNSHYTTASIAEYNKLKQQADNILNEDANHVETANRASQAAIDGLVTKLQAALIDNQAAIAELDAKAQEKVTAAQQSKKVTQDEVAALVTKINNDKNNAIAEINKQTTSQGVTTEKDNGIAVLEQDVITPTVKPQAKQDIIQAVTTRKQQIKKSNASLQDEKDVANDKIGKIETKAIKDIDAATTNAQVEAIKTKAINDINQTAPATTAKAAALEEFDEVVQAQIDQAPLNPDTTNEEVAEAIERINAAKVSDVKAIEATTTAQDLERVKNEEISKIENITDSTQTKMDAYNDVKQAATARKAQNATVSNATNEEVAEADAAVEAAQKQGLHDIQVVKSKQEVADTKSKVLDKINAIQTQAKVKPAADTEVENAYNTRKQEIQNSNASTTEEKQAAYTELDTKKQEARTNLDAANTNSDVTTAKDNSIAAINQVQAATTKKSDAKAEIAQKASERKTAIEAMNDSTTEEQQAAKDKVDQAVVTANTDIDNAAANTDVDNAKTTNEATIAAITPDANVKPTAKQAIADKVQAQETAIDAYNGATTEEKAAAKQQVQTEKTTADAAIDGAHSNAEVEAAKNAEIAKIEAIQPATTTKDDAKQAITTKANERKAAIAQTQDITAEEIAAANADVDNAVTQANSNIEAANSQNDVDQAKTTGETSIDQVTPTVNKKATARNEITTILNNKLQAIQATPDATDEEKQAADAEANTENGKANQAISAATTNAQVDEAKANAEVAINAVTPKVVKKQAAKDEIDQLQVAQTSVINNDQNATNEEKEAAIQQLATAVTDAKNNITAATDDNGVDQAKDAGKNSIQSTQPATAVKSNAKNEVDQAVTTQNQAIDNTTGATTEEKNAAKDLVLKAKEKAYQDILNAQTTNDVTQIKDQAVADVQGITADTTIKDVAKDELATKANEQKALIAQTADATTEEKEQANQQVDAQLTQGNQNIENAQSIDDVNTAKDNAIQAIDPIQASTDVKTNARAELLTEMQNKITEILSDNTTTNEEKGKDIEPVRATYEEGLNNINTANTTGDVTTAKDTAVQKVQQLHANPVKKPAGKTALDQAAADRKTQIEQTPNASQQEINDAKQEVDATLNQAKTNVDQSSTNEYVDNAVKEGKAKINAVKTFSEYKKDALAKIEAAYNSKVNEADNSNASTSSEIAEAKQKLAELKQTADQNVNQATSKDDIEVQIHNDLDNINDYTIPTGKKETATTDLYAYADQKKNNISADTNATQDEKQQAIKQVDQNVQTALESINNGVDNGDVDDALTQGKAAIDAIQVDATVKPKANQAIEAKAEDTKESIDHSDQLTAEEKTEALAMIKQITDQAKKGINDATTTAEVEKAKAQGLEAFDNIQIDSTEKQKAIEELETALDQIEAGVNVDADATTEEKEAFTNALEDILSKATEDISDQTTNAEIATVKNSALEQLKAQRINPEVKKNALEAIREVVNKQIEIIKNADASAKEIARTDLGRYFDRFADNLDKTQTNAEVAELQNVTIPAIEAIVPQNDPDANDTNNGTDNNDATANSNANATPENTGQPNVSETTDNGKADASPTTPNNSDAATGETTATSTNNPSTDDANNKPTANNNSSVDASTDNSATGNGTIDKPEVESTNNGTTDKPATETDNVTPAESTTNNNSTTATNENAPTGSTATAPTTASTEAASSADSKDNAFVNDSKQNAEVNNSAESQSTNGMVVQPKSENKAKAEKDGRDSTNQSMVESTTETLPSADITEPKVPSNTSKDKEESTTNQTDAGHLKSETNVASNEVDKSEGNVDTDVSNKPSTSKPSEAKDKATSTEDSQKADMATADTKDNQAAIGATADVNNKATQNDGANASPATVSNGSNSTNQDMLNVTKTEENKANVKSAQQGKVNKPKQQAKTLPDTGMSHNDDLPYAELALGAGMAFLIRRFTKKDQQTEE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	488008-488038	0	1.0
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	1092645-1092675	0	1.0
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	1521441-1521471	0	1.0
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	2184703-2184733	0	1.0
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	2184761-2184791	0	1.0
NZ_CP026067_6	6.1\|2621208\|34\|NZ_CP026067\|CRISPRCasFinder	2621208-2621241	34	NZ_CP026067.1	1264625-1264658	0	1.0
NZ_CP026067_6	6.1\|2621208\|34\|NZ_CP026067\|CRISPRCasFinder	2621208-2621241	34	NZ_CP026067.1	1309038-1309071	0	1.0
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	732915-732945	1	0.968
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	1092587-1092617	1	0.968
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	1264615-1264645	1	0.968
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	1423533-1423563	1	0.968
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	1547881-1547911	1	0.968
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	1711034-1711064	1	0.968
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	2218843-2218873	1	0.968
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	2515786-2515816	1	0.968
NZ_CP026067_3	3.1\|977274\|28\|NZ_CP026067\|CRISPRCasFinder	977274-977301	28	NZ_CP026067.1	1092704-1092731	1	0.964
NZ_CP026067_3	3.1\|977274\|28\|NZ_CP026067\|CRISPRCasFinder	977274-977301	28	NZ_CP026067.1	1264502-1264529	1	0.964
NZ_CP026067_3	3.1\|977274\|28\|NZ_CP026067\|CRISPRCasFinder	977274-977301	28	NZ_CP026067.1	2515843-2515870	1	0.964
NZ_CP026067_6	6.1\|2621208\|34\|NZ_CP026067\|CRISPRCasFinder	2621208-2621241	34	NZ_CP026067.1	825686-825719	1	0.971
NZ_CP026067_6	6.1\|2621208\|34\|NZ_CP026067\|CRISPRCasFinder	2621208-2621241	34	NZ_CP026067.1	825741-825774	1	0.971
NZ_CP026067_6	6.1\|2621208\|34\|NZ_CP026067\|CRISPRCasFinder	2621208-2621241	34	NZ_CP026067.1	1218513-1218546	1	0.971
NZ_CP026067_6	6.1\|2621208\|34\|NZ_CP026067\|CRISPRCasFinder	2621208-2621241	34	NZ_CP026067.1	1621056-1621089	1	0.971
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	825644-825674	2	0.935
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	977387-977417	2	0.935
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	977445-977475	2	0.935
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	1273657-1273687	2	0.935
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	1313115-1313145	2	0.935
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	2308714-2308744	2	0.935
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP026067.1	2308770-2308800	2	0.935
NZ_CP026067_3	3.1\|977274\|28\|NZ_CP026067\|CRISPRCasFinder	977274-977301	28	NZ_CP026067.1	1273601-1273628	2	0.929
NZ_CP026067_3	3.1\|977274\|28\|NZ_CP026067\|CRISPRCasFinder	977274-977301	28	NZ_CP026067.1	1710977-1711004	2	0.929
NZ_CP026067_6	6.1\|2621208\|34\|NZ_CP026067\|CRISPRCasFinder	2621208-2621241	34	NZ_CP026067.1	1313205-1313238	2	0.941
NZ_CP026067_6	6.1\|2621208\|34\|NZ_CP026067\|CRISPRCasFinder	2621208-2621241	34	NZ_CP026067.1	1875153-1875186	2	0.941

1. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 488008-488038, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

2. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 1092645-1092675, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

3. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 1521441-1521471, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

4. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 2184703-2184733, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

5. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 2184761-2184791, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

6. spacer 6.1|2621208|34|NZ_CP026067|CRISPRCasFinder matches to position: 1264625-1264658, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

7. spacer 6.1|2621208|34|NZ_CP026067|CRISPRCasFinder matches to position: 1309038-1309071, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

8. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 732915-732945, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcttttcgaaa	Protospacer
**.****************************

9. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 1092587-1092617, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcttttcgaaa	Protospacer
**.****************************

10. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 1264615-1264645, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcttgtagaatttcttttcgaaa	Protospacer
**********.********************

11. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 1423533-1423563, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcttttcgaaa	Protospacer
**.****************************

12. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 1547881-1547911, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattacctgtagaatttcttttcgaaa	Protospacer
********.**********************

13. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 1711034-1711064, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcatttcgaaa	Protospacer
********************** ********

14. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 2218843-2218873, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttctttacgaaa	Protospacer
************************* *****

15. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 2515786-2515816, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcttttcgaaa	Protospacer
**.****************************

16. spacer 3.1|977274|28|NZ_CP026067|CRISPRCasFinder matches to position: 1092704-1092731, mismatch: 1, identity: 0.964

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacgataatgtgca	Protospacer
********************** *****

17. spacer 3.1|977274|28|NZ_CP026067|CRISPRCasFinder matches to position: 1264502-1264529, mismatch: 1, identity: 0.964

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacgataatgtgca	Protospacer
********************** *****

18. spacer 3.1|977274|28|NZ_CP026067|CRISPRCasFinder matches to position: 2515843-2515870, mismatch: 1, identity: 0.964

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacgataatgtgca	Protospacer
********************** *****

19. spacer 6.1|2621208|34|NZ_CP026067|CRISPRCasFinder matches to position: 825686-825719, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctttgttgg	Protospacer
*************************** ******

20. spacer 6.1|2621208|34|NZ_CP026067|CRISPRCasFinder matches to position: 825741-825774, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctatgttgg	Protospacer
***************************.******

21. spacer 6.1|2621208|34|NZ_CP026067|CRISPRCasFinder matches to position: 1218513-1218546, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctttgttgg	Protospacer
*************************** ******

22. spacer 6.1|2621208|34|NZ_CP026067|CRISPRCasFinder matches to position: 1621056-1621089, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattatctgtgttgg	Protospacer
*********************** **********

23. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 825644-825674, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaattccttttcgaaa	Protospacer
**.*****************.**********

24. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 977387-977417, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgtctgtagaatttcttttcgaaa	Protospacer
**.******.*********************

25. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 977445-977475, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgtctgtagaatttcttttcgaaa	Protospacer
**.******.*********************

26. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 1273657-1273687, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcatttcgaaa	Protospacer
**.******************* ********

27. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 1313115-1313145, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcactgcctgtagaatttctttttgaaa	Protospacer
******.*******************.****

28. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 2308714-2308744, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgtctgtagaatttcttttcgaaa	Protospacer
**.******.*********************

29. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to position: 2308770-2308800, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgtctgtagaatttcttttcgaaa	Protospacer
**.******.*********************

30. spacer 3.1|977274|28|NZ_CP026067|CRISPRCasFinder matches to position: 1273601-1273628, mismatch: 2, identity: 0.929

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacaataatgtgca	Protospacer
*****************.**** *****

31. spacer 3.1|977274|28|NZ_CP026067|CRISPRCasFinder matches to position: 1710977-1711004, mismatch: 2, identity: 0.929

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacaataatgtgca	Protospacer
*****************.**** *****

32. spacer 6.1|2621208|34|NZ_CP026067|CRISPRCasFinder matches to position: 1313205-1313238, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaatcctctatgttgg	Protospacer
**********************.****.******

33. spacer 6.1|2621208|34|NZ_CP026067|CRISPRCasFinder matches to position: 1875153-1875186, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtgggatttcttttcgaaattctctgtgttgg	Protospacer
****.*.***************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP026067_3	3.1\|977274\|28\|NZ_CP026067\|CRISPRCasFinder	977274-977301	28	NC_021536	Synechococcus phage S-IOM18 genomic sequence	159754-159781	5	0.821
NZ_CP026067_3	3.1\|977274\|28\|NZ_CP026067\|CRISPRCasFinder	977274-977301	28	LN846932	Carnobacterium maltaromaticum strain LMA28 LMA_pa plamid, complete genome	10627-10654	6	0.786
NZ_CP026067_4	4.1\|1537755\|29\|NZ_CP026067\|CRISPRCasFinder	1537755-1537783	29	NZ_CP015322	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence	703321-703349	6	0.793
NZ_CP026067_3	3.1\|977274\|28\|NZ_CP026067\|CRISPRCasFinder	977274-977301	28	NZ_CP015319	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123a	9464-9491	7	0.75
NZ_CP026067_2	2.1\|453232\|31\|NZ_CP026067\|CRISPRCasFinder	453232-453262	31	NZ_CP009619	Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence	270870-270900	8	0.742

1. spacer 3.1|977274|28|NZ_CP026067|CRISPRCasFinder matches to NC_021536 (Synechococcus phage S-IOM18 genomic sequence) position: , mismatch: 5, identity: 0.821

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaactcaccttacgataaaattta	Protospacer
******* *** ***********.* .*

2. spacer 3.1|977274|28|NZ_CP026067|CRISPRCasFinder matches to LN846932 (Carnobacterium maltaromaticum strain LMA28 LMA_pa plamid, complete genome) position: , mismatch: 6, identity: 0.786

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaaatcagattacgataaattagt	Protospacer
*******.**** ********** *.

3. spacer 4.1|1537755|29|NZ_CP026067|CRISPRCasFinder matches to NZ_CP015322 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence) position: , mismatch: 6, identity: 0.793

taaaagagggatacttgcgctgagcgcat	CRISPR spacer
gatcaaagggttccttgcgctgagcgcat	Protospacer
 *  *.**** * ****************

4. spacer 3.1|977274|28|NZ_CP026067|CRISPRCasFinder matches to NZ_CP015319 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123a) position: , mismatch: 7, identity: 0.75

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
tcgaaatgtcagcttacgaaaaagcttt	Protospacer
 ***** ************ ****. .

5. spacer 2.1|453232|31|NZ_CP026067|CRISPRCasFinder matches to NZ_CP009619 (Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence) position: , mismatch: 8, identity: 0.742

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
gctgcattacctgtagcatttcttttttcaa	Protospacer
 ..*****.******* *********.  **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1196907 : 1204727

Hokovirus(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244415.1\|1196907_1197963_-	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_000149344.1\|1197962_1198649_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037811.1\|1198623_1199097_-	DoxX family protein	NA	NA	NA	NA
WP_001093557.1\|1199438_1199879_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637683.1\|1200158_1200743_-	hypothetical protein	NA	NA	NA	NA
WP_001062968.1\|1200841_1201555_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941334.1\|1201558_1201978_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446721.1\|1201979_1202648_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.1
WP_000604509.1\|1202998_1203592_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	1.5e-38	44.0
WP_001217797.1\|1203575_1204727_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	2.1e-23	36.1

DBSCAN-SWA_2

1216699 : 1230892

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663031.1\|1216699_1217758_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	2.3e-21	26.4
WP_000197262.1\|1217915_1218458_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429016.1\|1219063_1219981_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	2.1e-07	22.4
WP_000193751.1\|1220262_1221768_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930020.1\|1222107_1222608_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	2.2e-51	70.8
WP_001068497.1\|1222627_1223494_-	DMT family transporter	NA	NA	NA	NA
WP_000692523.1\|1224294_1224693_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	4.3e-53	72.7
WP_000855505.1\|1224655_1226761_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|1226878_1227850_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000499194.1\|1228025_1228181_+	hypothetical protein	NA	NA	NA	NA
WP_047213721.1\|1228219_1229188_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	8.0e-138	79.1
WP_001245577.1\|1229177_1230134_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
WP_000616870.1\|1230130_1230892_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	5.0e-18	31.6

DBSCAN-SWA_3

1317450 : 1366157

Staphylococcus_virus(48.53%)

holin,portal,head,capsid,transposase,terminase,plate,integrase

attL 1309090:1309105|attR 1322575:1322590

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1309090:1309105	attL	NA	NA	NA	NA
WP_001006454.1\|1317450_1318701_+	cysteine desulfurase	Q2XUY6	environmental_halophage	1.4e-110	44.5
WP_001010508.1\|1318690_1319155_+	SUF system NifU family Fe-S cluster assembly protein	NA	NA	NA	NA
WP_001074405.1\|1319306_1320704_+	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
WP_015967223.1\|1320771_1321821_-\|integrase	site-specific integrase	Q9G044	Staphylococcus_virus	2.0e-203	100.0
WP_015967224.1\|1321878_1322250_-	hypothetical protein	Q9G043	Staphylococcus_virus	4.1e-34	100.0
WP_015967225.1\|1322239_1322665_-	hypothetical protein	Q9G042	Staphylococcus_virus	6.1e-74	100.0
1322575:1322590	attR	NA	NA	NA	NA
WP_015967226.1\|1322720_1322906_-	hypothetical protein	Q9G041	Staphylococcus_virus	3.0e-25	100.0
WP_001049401.1\|1322902_1323049_-	hypothetical protein	U5U441	Staphylococcus_phage	4.3e-19	100.0
WP_015967227.1\|1323060_1323777_-	helix-turn-helix domain-containing protein	Q9G039	Staphylococcus_virus	9.2e-131	100.0
WP_000639927.1\|1323940_1324183_+	DUF739 family protein	Q9G038	Staphylococcus_virus	2.8e-39	100.0
WP_000393082.1\|1324198_1324378_+	hypothetical protein	A0A0H3U490	Staphylococcus_phage	4.4e-26	100.0
WP_000394410.1\|1324478_1324961_-	hypothetical protein	A0A0N9BAX2	Staphylococcus_phage	1.1e-82	100.0
WP_000933365.1\|1325405_1325591_+	helix-turn-helix transcriptional regulator	A0A0H4IP57	Staphylococcus_phage	1.3e-25	100.0
WP_015967228.1\|1325592_1326345_+	hypothetical protein	Q9G034	Staphylococcus_virus	9.6e-139	100.0
WP_047213263.1\|1326452_1326665_-	hypothetical protein	A0A2H4JBA9	uncultured_Caudovirales_phage	1.6e-14	55.1
WP_047213265.1\|1326721_1327471_+	oxidoreductase	B7T097	Staphylococcus_virus	4.9e-135	98.8
WP_015967229.1\|1327575_1328241_-	hypothetical protein	Q9G033	Staphylococcus_virus	1.3e-118	100.0
WP_000594792.1\|1328311_1328533_+	hypothetical protein	A0A0H4ISQ0	Staphylococcus_phage	1.5e-31	100.0
WP_000048124.1\|1328525_1328687_+	DUF1270 family protein	C7F7L3	Staphylococcus_phage	1.9e-20	100.0
WP_015967230.1\|1328780_1329041_+	DUF1108 family protein	C7F7L4	Staphylococcus_phage	1.5e-43	100.0
WP_001077280.1\|1329050_1329272_+	DUF2483 family protein	A0A0E3TAJ7	Staphylococcus_phage	2.4e-34	100.0
WP_047213269.1\|1329264_1330044_+	ATP-binding protein	Q9G028	Staphylococcus_virus	1.3e-141	99.6
WP_015978330.1\|1330072_1330624_+	hypothetical protein	A0A0H4IPV5	Staphylococcus_phage	3.4e-101	100.0
WP_047213271.1\|1330636_1331302_+	hypothetical protein	Q4ZDQ9	Staphylococcus_virus	1.7e-126	99.5
WP_047213273.1\|1331487_1331898_-	hypothetical protein	Q4ZDQ7	Staphylococcus_virus	9.4e-72	98.5
WP_001566734.1\|1331960_1332731_+	hypothetical protein	A0A0H4IPD8	Staphylococcus_phage	8.4e-122	100.0
WP_000803063.1\|1332740_1333520_+	ATP-binding protein	A0A068A1Z4	Staphylococcus_phage	2.9e-146	100.0
WP_000256594.1\|1333513_1333672_+	hypothetical protein	A0A2I6PDX0	Staphylococcus_phage	4.5e-22	98.1
WP_001123681.1\|1333685_1333907_+	DUF3269 family protein	A0A2H4PQI9	Staphylococcus_phage	2.2e-35	100.0
WP_029549553.1\|1333916_1334324_+	RusA family crossover junction endodeoxyribonuclease	A9CR74	Staphylococcus_phage	8.4e-73	98.5
WP_029549552.1\|1334323_1334509_+	DUF3113 family protein	M9NSS9	Staphylococcus_phage	7.0e-27	98.4
WP_015967239.1\|1334772_1334943_+	hypothetical protein	Q9G017	Staphylococcus_virus	1.0e-24	100.0
WP_001566727.1\|1335369_1335522_+	DUF1024 family protein	Q9G015	Staphylococcus_virus	3.3e-22	100.0
WP_015967241.1\|1335518_1335803_+	hypothetical protein	Q9G014	Staphylococcus_virus	3.6e-46	100.0
WP_015967242.1\|1335795_1336038_+	DUF1024 family protein	Q9G013	Staphylococcus_virus	1.3e-36	100.0
WP_015967243.1\|1336037_1336280_+	hypothetical protein	Q9G012	Staphylococcus_virus	1.4e-35	100.0
WP_015967244.1\|1336272_1336809_+	hypothetical protein	Q9G011	Staphylococcus_virus	4.2e-96	100.0
WP_000195803.1\|1336845_1337052_+	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
WP_000592207.1\|1337048_1337435_+	hypothetical protein	W5R986	Staphylococcus_phage	3.0e-64	100.0
WP_000595257.1\|1337431_1337605_+	transcriptional activator RinB	Q4ZBK0	Staphylococcus_phage	6.4e-22	100.0
WP_000286968.1\|1337605_1338007_+	hypothetical protein	A0A2H4PQK5	Staphylococcus_phage	5.6e-69	100.0
WP_000594085.1\|1338358_1338853_+	hypothetical protein	A0A0H4J343	Staphylococcus_phage	8.4e-83	100.0
WP_001807202.1\|1338845_1340054_+\|terminase	PBSX family phage terminase large subunit	A0A0H4ITX6	Staphylococcus_phage	1.0e-235	100.0
WP_001159669.1\|1340007_1341486_+\|portal	phage portal protein	Q4ZB45	Staphylococcus_virus	4.3e-284	99.6
WP_047213283.1\|1341424_1342405_+\|capsid	minor capsid protein	A0A0E3XC69	Staphylococcus_phage	5.9e-181	99.1
WP_015967248.1\|1342502_1343099_+	hypothetical protein	C7F7L8	Staphylococcus_phage	3.4e-78	100.0
WP_015967249.1\|1343119_1343944_+\|capsid	N4-gp56 family major capsid protein	Q9G001	Staphylococcus_virus	1.2e-147	100.0
WP_015967250.1\|1343960_1344287_+	hypothetical protein	Q9G000	Staphylococcus_virus	3.3e-51	100.0
WP_015967251.1\|1344286_1344601_+	hypothetical protein	Q9FZZ9	Staphylococcus_virus	3.4e-53	100.0
WP_015967252.1\|1344593_1344929_+\|head	phage head closure protein	Q9FZZ8	Staphylococcus_virus	2.3e-60	100.0
WP_001151332.1\|1344915_1345329_+	HK97 gp10 family phage protein	A0A0E3XCY8	Staphylococcus_phage	1.5e-77	100.0
WP_015967254.1\|1345341_1345779_+	DUF3168 domain-containing protein	A0A2H4PQL6	Staphylococcus_phage	1.6e-77	100.0
WP_000046067.1\|1345765_1346326_+	hypothetical protein	A0A0H4ITY2	Staphylococcus_phage	5.9e-101	100.0
WP_000141084.1\|1346387_1346882_+	hypothetical protein	A0A0H4IPX9	Staphylococcus_phage	2.5e-87	100.0
WP_000204079.1\|1346902_1347244_+	hypothetical protein	W5R8J4	Staphylococcus_phage	3.5e-56	100.0
WP_047213286.1\|1347246_1350216_+\|terminase	terminase	Q9FZZ2	Staphylococcus_virus	6.5e-263	100.0
WP_015967256.1\|1350230_1351166_+	hypothetical protein	Q9FZZ1	Staphylococcus_virus	4.8e-180	100.0
WP_015967257.1\|1351176_1353063_+	hypothetical protein	Q9FZZ0	Staphylococcus_virus	0.0e+00	100.0
WP_015967258.1\|1353075_1354974_+	hypothetical protein	Q9FZY9	Staphylococcus_virus	0.0e+00	100.0
WP_015967259.1\|1354973_1356797_+\|plate	BppU family phage baseplate upper protein	Q9FZY8	Staphylococcus_virus	4.6e-296	100.0
WP_000705910.1\|1356796_1357174_+	DUF2977 domain-containing protein	Q9FZY7	Staphylococcus_virus	1.2e-60	100.0
WP_000782200.1\|1357177_1357351_+	XkdX family protein	A0A0F6N3L7	Staphylococcus_phage	6.6e-27	100.0
WP_000466784.1\|1357391_1357691_+	DUF2951 domain-containing protein	A0A2I6PER2	Staphylococcus_phage	2.0e-31	100.0
WP_015967260.1\|1357827_1359702_+	CHAP domain-containing protein	Q9FZY4	Staphylococcus_virus	0.0e+00	100.0
WP_047213289.1\|1359714_1360953_+\|plate	BppU family phage baseplate upper protein	Q9FZY3	Staphylococcus_virus	7.7e-210	99.8
WP_001576757.1\|1360958_1361354_+	hypothetical protein	Q9FZY2	Staphylococcus_virus	1.6e-68	100.0
WP_000351119.1\|1361410_1361686_+\|holin	phage holin	A0A0F6N3M0	Staphylococcus_phage	8.6e-45	100.0
WP_015967262.1\|1361672_1363085_+	CHAP domain-containing protein	Q9FZY0	Staphylococcus_virus	2.0e-286	100.0
WP_001065781.1\|1363210_1364053_+	exfoliative toxin A	A0A0E3T8P7	Staphylococcus_phage	2.3e-157	100.0
WP_103225777.1\|1364589_1366157_-\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	1.7e-49	51.4

DBSCAN-SWA_4

1772050 : 1825362

Bacillus_phage(26.67%)

portal,protease,tail,head,transposase,terminase,integrase,tRNA

attL 1793727:1793764|attR 1834590:1834627

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001001521.1\|1772050_1773595_+\|tRNA	tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB	NA	NA	NA	NA
WP_000282386.1\|1773595_1773961_+	hypothetical protein	NA	NA	NA	NA
WP_000842277.1\|1773987_1774479_+	energy coupling factor transporter S component ThiW	NA	NA	NA	NA
WP_000073332.1\|1774781_1777400_+	DNA mismatch repair protein MutS	E3T5Q7	Cafeteria_roenbergensis_virus	5.0e-41	23.7
WP_000516257.1\|1777412_1779422_+	DNA mismatch repair endonuclease MutL	A0A1B2LRQ5	Wolbachia_phage	5.3e-59	29.5
WP_047213403.1\|1779427_1779970_+	glycerol-3-phosphate responsive antiterminator	NA	NA	NA	NA
WP_001103747.1\|1780444_1781263_+	aquaporin family protein	M1H4F4	Acanthocystis_turfacea_Chlorella_virus	3.1e-26	35.1
WP_000417379.1\|1781391_1782888_+	glycerol kinase GlpK	NA	NA	NA	NA
WP_001218598.1\|1783045_1784719_+	glycerol-3-phosphate dehydrogenase/oxidase	NA	NA	NA	NA
WP_000136955.1\|1784868_1785783_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_001798536.1\|1785800_1786736_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_000561359.1\|1786750_1786984_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_047213134.1\|1787245_1788565_-\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA
WP_000448078.1\|1788725_1789202_-	glutathione peroxidase	Q70H87	Fowlpox_virus	1.2e-22	38.0
WP_047213405.1\|1789313_1790552_+	GTPase HflX	NA	NA	NA	NA
WP_000652044.1\|1790570_1791809_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_000624945.1\|1792051_1792420_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_001126603.1\|1792438_1793779_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
1793727:1793764	attL	NA	NA	NA	NA
WP_000135759.1\|1793918_1795046_-\|integrase	site-specific integrase	A0A0C5AN64	Paenibacillus_phage	3.7e-33	31.4
WP_047213408.1\|1795098_1795794_-	hypothetical protein	A0A2H4J5B8	uncultured_Caudovirales_phage	1.8e-06	40.9
WP_000554410.1\|1795805_1796189_-	hypothetical protein	NA	NA	NA	NA
WP_047212960.1\|1796384_1797704_+\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA
WP_000664916.1\|1797860_1798253_-	helix-turn-helix domain-containing protein	A0A2I6PE55	Staphylococcus_phage	2.7e-28	53.6
WP_001209962.1\|1798420_1798639_+	DUF739 family protein	A0A2I6PE94	Staphylococcus_phage	4.9e-19	62.5
WP_000932237.1\|1798665_1798941_+	hypothetical protein	NA	NA	NA	NA
WP_000662665.1\|1799205_1799376_+	hypothetical protein	Q4ZDZ8	Staphylococcus_virus	1.8e-21	89.3
WP_000800340.1\|1799364_1799571_-	hypothetical protein	A1BTY8	Staphylococcus_virus	4.3e-25	75.0
WP_001157026.1\|1799630_1800314_+	phage repressor protein	A9CR56	Staphylococcus_phage	8.0e-108	86.0
WP_000072840.1\|1800412_1800574_+	DUF1270 family protein	R4IH12	Staphylococcus_phage	1.1e-12	69.8
WP_000786635.1\|1800967_1801234_+	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	3.9e-18	53.6
WP_001002734.1\|1801238_1802489_+	helicase SNF2	A0A1B1P7L4	Bacillus_phage	1.8e-134	57.8
WP_025174483.1\|1802479_1802797_+	hypothetical protein	A0A2P0ZLA7	Lactobacillus_phage	7.1e-19	43.2
WP_000160835.1\|1802789_1803095_+	hypothetical protein	A0A1B1P7M6	Bacillus_phage	5.8e-26	59.3
WP_031927619.1\|1803084_1804911_+	AAA family ATPase	A0A1B1P7N0	Bacillus_phage	2.6e-166	56.3
WP_001250666.1\|1804928_1805135_+	hypothetical protein	NA	NA	NA	NA
WP_000140895.1\|1805180_1805663_+	DUF669 domain-containing protein	A0A2H4J1S8	uncultured_Caudovirales_phage	2.9e-19	37.3
WP_000560476.1\|1805944_1807663_+	hypothetical protein	A0A1B1P7M5	Bacillus_phage	1.9e-211	63.6
WP_000394569.1\|1807766_1808156_+	hypothetical protein	U3PG42	Staphylococcus_phage	4.5e-07	51.9
WP_000792984.1\|1808231_1808537_+	hypothetical protein	A0A2H4JF73	uncultured_Caudovirales_phage	6.2e-36	73.7
WP_000231299.1\|1808559_1809030_-	hypothetical protein	NA	NA	NA	NA
WP_000584491.1\|1809450_1809642_+	hypothetical protein	NA	NA	NA	NA
WP_000276481.1\|1809673_1811548_+	DNA primase	A0A1B1P7L5	Bacillus_phage	1.1e-210	57.6
WP_000933402.1\|1811852_1812344_+	hypothetical protein	S5MAA9	Brevibacillus_phage	7.4e-07	30.0
WP_000870118.1\|1812776_1813067_+	HNH endonuclease	D2XR61	Bacillus_phage	1.3e-19	43.2
WP_000868798.1\|1813385_1813718_+	hypothetical protein	NA	NA	NA	NA
WP_046463075.1\|1813701_1815345_+\|terminase	terminase large subunit	A0A0U4B089	Bacillus_phage	8.4e-180	57.3
WP_000523761.1\|1815360_1816497_+\|portal	phage portal protein	A0A2H4JBZ5	uncultured_Caudovirales_phage	7.8e-84	41.4
WP_047213417.1\|1816496_1817183_+\|protease	Clp protease ClpP	A0A2H4J8Y7	uncultured_Caudovirales_phage	1.4e-43	49.5
WP_000152780.1\|1817209_1818379_+	hypothetical protein	A0A0U4JIF4	Bacillus_phage	1.2e-98	50.5
WP_000406284.1\|1818400_1818706_+	hypothetical protein	A0A059T7R0	Listeria_phage	6.0e-15	44.8
WP_000744618.1\|1818680_1819025_+\|head	phage head closure protein	NA	NA	NA	NA
WP_000114215.1\|1819008_1819347_+	hypothetical protein	NA	NA	NA	NA
WP_000072314.1\|1819346_1819784_+	hypothetical protein	NA	NA	NA	NA
WP_000213868.1\|1819789_1820473_+	hypothetical protein	NA	NA	NA	NA
WP_000021684.1\|1820500_1820851_+	hypothetical protein	NA	NA	NA	NA
WP_000159313.1\|1820898_1821123_+	hypothetical protein	NA	NA	NA	NA
WP_031927625.1\|1821180_1825362_+\|tail	phage tail tape measure protein	Q9T0X1	Lactobacillus_phage	3.2e-58	42.6
1834590:1834627	attR	NA	NA	NA	NA

DBSCAN-SWA_5

1829550 : 1835996

Staphylococcus_phage(83.33%)

capsid,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000569801.1\|1829550_1829961_+	hypothetical protein	A0A1I9KKA6	Lactobacillus_phage	3.9e-09	32.8
WP_000665466.1\|1829995_1830310_+	hypothetical protein	NA	NA	NA	NA
WP_047213423.1\|1830293_1830677_+\|holin	phage holin family protein	H9A0W5	Staphylococcus_phage	4.3e-18	39.2
WP_031927627.1\|1830741_1831662_+	N-acetylmuramoyl-L-alanine amidase	A0A1W6JQL2	Staphylococcus_phage	1.2e-66	50.2
WP_001793526.1\|1832138_1832336_+	hypothetical protein	A0A1W6JNK0	Staphylococcus_phage	9.9e-11	50.0
WP_001019311.1\|1832529_1833033_+	hypothetical protein	NA	NA	NA	NA
WP_000459699.1\|1833045_1833360_+	hypothetical protein	NA	NA	NA	NA
WP_000907423.1\|1833359_1833788_+	hypothetical protein	NA	NA	NA	NA
WP_000997672.1\|1834191_1834401_+	helix-turn-helix domain-containing protein	A0A1W6JNK0	Staphylococcus_phage	1.9e-12	59.4
WP_052724874.1\|1834655_1835996_+\|capsid	minor capsid protein	A0A1J0MFV1	Staphylococcus_phage	7.0e-140	58.7

DBSCAN-SWA_6

2012461 : 2098864

100

Staphylococcus_phage(77.78%)

holin,protease,tail,portal,capsid,transposase,terminase,plate,integrase,head,tRNA

attL 2049690:2049718|attR 2093949:2093977

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000858797.1\|2012461_2013754_-\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	1.5e-54	30.0
WP_000525073.1\|2014075_2016769_-	ATP-dependent helicase DinG	A0A1X9I5C8	Streptococcus_phage	8.2e-47	34.4
WP_000049912.1\|2016792_2017764_-	biotin--[acetyl-CoA-carboxylase] ligase	NA	NA	NA	NA
WP_001043250.1\|2017750_2018953_-\|tRNA	CCA tRNA nucleotidyltransferase	G3MAR3	Bacillus_virus	2.0e-29	27.9
WP_000690018.1\|2018957_2020100_-	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA	NA	NA	NA	NA
WP_000839926.1\|2020343_2020661_-	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_001827022.1\|2020996_2021677_-	zinc metallopeptidase	NA	NA	NA	NA
WP_000154688.1\|2021748_2022336_-	DUF1405 domain-containing protein	NA	NA	NA	NA
WP_047213454.1\|2022325_2022901_-	IDEAL domain-containing protein	G3MAV7	Bacillus_virus	1.0e-07	26.7
WP_000389525.1\|2022914_2024159_-	hypothetical protein	NA	NA	NA	NA
WP_000245910.1\|2024165_2025464_-	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_000776332.1\|2025473_2026538_-	3-dehydroquinate synthase	NA	NA	NA	NA
WP_001269935.1\|2026563_2027730_-	chorismate synthase	A0A291AU41	Pandoravirus	2.0e-34	32.3
WP_047213134.1\|2028155_2029475_+\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA
WP_000442480.1\|2029718_2030168_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	2.4e-28	43.8
WP_016169114.1\|2030259_2031204_-	heptaprenyl diphosphate synthase component II	A0A1V0SE37	Indivirus	1.3e-10	24.4
WP_000774684.1\|2031220_2031946_-	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_000450555.1\|2031948_2032521_-	heptaprenyl diphosphate synthase component 1	NA	NA	NA	NA
WP_001043863.1\|2032951_2033224_-	HU family DNA-binding protein	A7KV42	Bacillus_phage	4.2e-28	73.3
WP_000161743.1\|2033394_2034393_-	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_000165530.1\|2034409_2035720_-	ribosome biogenesis GTPase Der	NA	NA	NA	NA
WP_000133955.1\|2035941_2037117_-	30S ribosomal protein S1	NA	NA	NA	NA
WP_031927466.1\|2037373_2037565_-	hypothetical protein	NA	NA	NA	NA
WP_031844926.1\|2037681_2037786_-	hypothetical protein	NA	NA	NA	NA
WP_000644392.1\|2037828_2038488_-	(d)CMP kinase	NA	NA	NA	NA
WP_029549671.1\|2038564_2039533_+	asparaginase	NA	NA	NA	NA
WP_001174260.1\|2039647_2040634_-	YpdA family putative bacillithiol disulfide reductase	NA	NA	NA	NA
WP_031927468.1\|2040827_2040911_-	hypothetical protein	NA	NA	NA	NA
WP_000069302.1\|2041035_2042319_-	elastin-binding protein EbpS	NA	NA	NA	NA
WP_000902112.1\|2042471_2043851_-	ATP-dependent DNA helicase RecQ	L7RCS0	Acanthamoeba_polyphaga_moumouvirus	3.8e-56	33.6
WP_001163818.1\|2043840_2044794_-	hypothetical protein	NA	NA	NA	NA
WP_001151998.1\|2044901_2045150_+	ferredoxin	A0A127AYY7	Bacillus_phage	1.9e-14	46.7
WP_001186910.1\|2045255_2045801_-	ECF transporter S component	NA	NA	NA	NA
WP_047213459.1\|2047395_2047542_-	hypothetical protein	NA	NA	NA	NA
WP_047213461.1\|2047534_2048461_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000913240.1\|2048518_2049424_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_047213463.1\|2049513_2049729_-	hypothetical protein	A0ZS61	Staphylococcus_virus	5.9e-25	98.4
2049690:2049718	attL	NA	NA	NA	NA
WP_000909205.1\|2050450_2051905_-	CHAP domain-containing protein	A0A2I6PF47	Staphylococcus_phage	2.8e-288	99.6
WP_000339144.1\|2051915_2052218_-\|holin	phage holin	B7T0L0	Staphylococcus_virus	4.1e-48	100.0
WP_000466784.1\|2052353_2052653_-	DUF2951 domain-containing protein	A0A2I6PER2	Staphylococcus_phage	2.0e-31	100.0
WP_000916020.1\|2052698_2052863_-	XkdX family protein	A0A2I6PES4	Staphylococcus_phage	4.9e-24	100.0
WP_001166599.1\|2052855_2053245_-	DUF2977 domain-containing protein	A0A2I6PER1	Staphylococcus_phage	2.2e-62	100.0
WP_000067127.1\|2053244_2054711_-\|plate	BppU family phage baseplate upper protein	A0A2I6PES7	Staphylococcus_phage	1.5e-273	100.0
WP_000429558.1\|2054710_2056621_-	minor structural protein	A0A2I6PEQ9	Staphylococcus_phage	0.0e+00	100.0
WP_000179858.1\|2056636_2056927_-	hypothetical protein	U5U457	Staphylococcus_phage	2.1e-49	100.0
WP_000384474.1\|2056926_2058510_-	peptidase	A0A2I6PEQ5	Staphylococcus_phage	9.3e-309	100.0
WP_001190533.1\|2058518_2059343_-\|tail	phage tail family protein	A0A2I6PER3	Staphylococcus_phage	4.1e-159	100.0
WP_047213465.1\|2059342_2065543_-\|tail	phage tail tape measure protein	A0A1X9IGU9	Staphylococcus_phage	0.0e+00	99.5
WP_000438833.1\|2065556_2065715_-	hypothetical protein	A0A2I6PES8	Staphylococcus_phage	1.2e-19	100.0
WP_000589167.1\|2065756_2066107_-	hypothetical protein	A0A2I6PEQ2	Staphylococcus_phage	1.1e-55	100.0
WP_047213467.1\|2066164_2066620_-	Ig domain-containing protein	A0A2I6PER6	Staphylococcus_phage	2.2e-77	99.3
WP_000807536.1\|2066711_2067353_-\|tail	tail protein	A0A2I6PEP6	Staphylococcus_phage	5.9e-121	100.0
WP_001023806.1\|2067387_2067783_-	DUF3168 domain-containing protein	A0A2I6PEQ4	Staphylococcus_phage	8.8e-67	100.0
WP_000110023.1\|2067783_2068185_-	hypothetical protein	A0A2I6PF54	Staphylococcus_phage	8.1e-68	100.0
WP_000395498.1\|2068181_2068514_-	hypothetical protein	A0A2I6PES3	Staphylococcus_phage	4.1e-57	100.0
WP_000050973.1\|2068525_2068804_-\|head,tail	phage gp6-like head-tail connector protein	A0A2I6PEQ1	Staphylococcus_phage	2.1e-46	100.0
WP_001142734.1\|2068872_2070036_-\|capsid	phage major capsid protein	A0A2I6PEQ3	Staphylococcus_phage	1.2e-217	100.0
WP_000061866.1\|2070047_2070821_-\|protease	Clp protease ClpP	A0A2I6PEQ7	Staphylococcus_phage	2.4e-137	100.0
WP_001100669.1\|2070804_2072043_-\|portal	phage portal protein	A0A2K9VBP0	Staphylococcus_phage	6.9e-235	100.0
WP_000153541.1\|2072047_2073739_-\|terminase	terminase large subunit	A0A2I6PE44	Staphylococcus_phage	0.0e+00	99.8
WP_000778933.1\|2073728_2074034_-\|terminase	terminase	A0A2I6PEQ6	Staphylococcus_phage	2.9e-49	100.0
WP_000160689.1\|2074162_2074477_-	HNH endonuclease	A0A2I6PDC4	Staphylococcus_phage	2.5e-56	100.0
WP_000528514.1\|2074633_2075071_-	transcriptional regulator	B5WZN8	Staphylococcus_phage	2.7e-77	100.0
WP_001793488.1\|2075083_2076451_-	DEAD/DEAH box helicase	A0A2I6PE95	Staphylococcus_phage	1.7e-263	100.0
WP_000665205.1\|2076431_2076722_-	VRR-NUC domain-containing protein	U5U7A3	Staphylococcus_phage	4.9e-51	100.0
WP_015978074.1\|2076855_2076960_+	hypothetical protein	A0A2I6PDP6	Staphylococcus_phage	2.7e-12	100.0
WP_015994231.1\|2077062_2079510_-	virulence-associated protein E	B5WZN5	Staphylococcus_phage	0.0e+00	100.0
WP_000265258.1\|2079562_2079763_-	DUF1514 family protein	A0A2I6PF41	Staphylococcus_phage	2.9e-26	100.0
WP_000595237.1\|2079830_2079983_-	transcriptional activator RinB	B5WZN3	Staphylococcus_phage	2.6e-19	100.0
WP_000483477.1\|2079975_2080212_-	hypothetical protein	A7TWB3	Staphylococcus_phage	1.9e-37	100.0
WP_000195806.1\|2080236_2080473_-	DUF1381 domain-containing protein	C8CH06	Staphylococcus_phage	3.1e-35	98.7
WP_000185703.1\|2080509_2081046_-	hypothetical protein	S4V978	Staphylococcus_phage	1.0e-94	98.9
WP_000028425.1\|2081038_2081221_-	hypothetical protein	D2JGL7	Staphylococcus_phage	2.6e-26	100.0
WP_047213471.1\|2081210_2081462_-	DUF1024 family protein	W5R8J0	Staphylococcus_phage	6.4e-39	98.8
WP_000132194.1\|2081476_2081719_-	hypothetical protein	A0A2I6PEV3	Staphylococcus_phage	1.5e-40	100.0
WP_000235324.1\|2081733_2081934_-	hypothetical protein	A0A2I6PEM3	Staphylococcus_phage	2.5e-30	100.0
WP_047213473.1\|2081936_2082194_-	DUF3310 domain-containing protein	A0A2I6PEN5	Staphylococcus_phage	1.7e-42	100.0
WP_000113974.1\|2082193_2082595_-	PVL family protein	A0A2I6PEL5	Staphylococcus_phage	1.2e-68	100.0
WP_001802096.1\|2082791_2084744_-	DNA polymerase	A0A2I6PE86	Staphylococcus_phage	0.0e+00	100.0
WP_047213475.1\|2084811_2085369_-	DUF2815 family protein	A0A2K9VBT2	Staphylococcus_phage	2.0e-96	99.5
WP_000762530.1\|2085394_2086561_-	DUF2800 domain-containing protein	B5WZM3	Staphylococcus_phage	8.3e-222	100.0
WP_000279452.1\|2086557_2086920_-	hypothetical protein	Q4ZCH9	Staphylococcus_virus	2.9e-56	100.0
WP_000174996.1\|2086934_2087258_-	hypothetical protein	B7T0G4	Staphylococcus_virus	8.5e-52	100.0
WP_001285961.1\|2087337_2087499_-	DUF1270 domain-containing protein	Q4ZCI2	Staphylococcus_virus	1.9e-20	100.0
WP_001124160.1\|2087511_2087775_-	helix-turn-helix domain-containing protein	A7TWG0	Staphylococcus_phage	5.7e-46	100.0
WP_001097552.1\|2087799_2088015_-	hypothetical protein	A0A2I6PF01	Staphylococcus_phage	1.9e-31	100.0
WP_047213477.1\|2088069_2088435_+	hypothetical protein	A0A2I6PF07	Staphylococcus_phage	9.3e-63	99.2
WP_001025401.1\|2088403_2088649_-	DUF2829 domain-containing protein	A0A2I6PF15	Staphylococcus_phage	5.1e-41	100.0
WP_001001383.1\|2088698_2088917_-	hypothetical protein	B5WZL5	Staphylococcus_phage	7.8e-33	100.0
WP_001030311.1\|2089513_2089741_-	hypothetical protein	B5WZL3	Staphylococcus_phage	3.3e-34	100.0
WP_000801423.1\|2089912_2090527_+	helix-turn-helix domain-containing protein	B5WZL2	Staphylococcus_phage	9.0e-111	100.0
WP_000348133.1\|2090542_2091463_+	exonuclease	B5WZL1	Staphylococcus_phage	2.5e-173	100.0
WP_000705240.1\|2091558_2091741_+	hypothetical protein	A0A2I6PDR4	Staphylococcus_phage	5.3e-27	100.0
WP_001794606.1\|2091776_2091923_+	hypothetical protein	A0A2I6PEK8	Staphylococcus_phage	2.6e-16	97.9
WP_000191466.1\|2091919_2092534_-	hypothetical protein	A0A2I6PEZ0	Staphylococcus_phage	6.7e-106	100.0
WP_000264751.1\|2092659_2093865_+\|integrase	site-specific integrase	A0A2I6PEN0	Staphylococcus_phage	7.7e-223	100.0
WP_072472527.1\|2093907_2094675_-	hypothetical protein	B5WZK7	Staphylococcus_phage	4.5e-43	46.5
2093949:2093977	attR	NA	NA	NA	NA
WP_072403849.1\|2094689_2095949_-	hypothetical protein	NA	NA	NA	NA
WP_031927558.1\|2095935_2096868_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000987769.1\|2097112_2098864_-	HAMP domain-containing protein	A0A1V0SGX0	Hokovirus	1.7e-21	33.6

DBSCAN-SWA_7

2156211 : 2164523

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001213908.1\|2156211_2156997_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
WP_000924216.1\|2157122_2158013_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
WP_047213497.1\|2158022_2159369_-	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	2.4e-55	34.0
WP_000683926.1\|2159482_2160583_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	2.3e-08	30.6
WP_000624574.1\|2160585_2161263_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_001283055.1\|2161393_2162500_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_001217266.1\|2162723_2164523_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	1.3e-53	36.3

DBSCAN-SWA_8

2234060 : 2243103

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|2234060_2234579_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_042908036.1\|2234600_2236874_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	8.1e-64	29.3
WP_000749803.1\|2237076_2239356_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|2239630_2239891_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|2239909_2241049_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001019170.1\|2241071_2242097_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005767.1\|2242098_2243103_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_9

2371886 : 2428661

Staphylococcus_phage(95.45%)

protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047213547.1\|2371886_2378426_-	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	9.5e-291	92.5
WP_000836469.1\|2378751_2379063_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	4.5e-50	96.1
WP_001108719.1\|2379084_2381499_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.3
WP_001025061.1\|2381789_2382971_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	5.6e-218	100.0
WP_000526539.1\|2383080_2384034_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
WP_000764419.1\|2384030_2384594_+	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	8.3e-103	99.5
WP_000757543.1\|2384713_2385115_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266089.1\|2385686_2386514_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_072357767.1\|2386516_2386636_-	hypothetical protein	NA	NA	NA	NA
WP_001196354.1\|2386747_2387749_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7
WP_001008551.1\|2387870_2388335_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
WP_047213550.1\|2388347_2389529_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	5.1e-227	99.7
WP_000493884.1\|2389539_2390172_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.4e-111	98.6
WP_078103423.1\|2390178_2391210_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	2.0e-195	98.5
WP_047213554.1\|2391702_2393205_-	FAD-dependent oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	8.6e-30	98.6
WP_000221188.1\|2393725_2394040_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	2.8e-52	97.1
WP_000989112.1\|2394039_2395332_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	8.8e-225	97.7
WP_000163240.1\|2395349_2395745_+	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	2.4e-72	99.2
WP_001032833.1\|2396094_2396949_-	autolysin	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|2397224_2397449_-	hypothetical protein	NA	NA	NA	NA
WP_000671048.1\|2397647_2398118_+	RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	4.8e-80	96.8
WP_001153740.1\|2398230_2398674_+	competence protein ComK	NA	NA	NA	NA
WP_001030469.1\|2398660_2399104_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	2.4e-57	98.6
WP_001168909.1\|2399401_2400037_+\|protease	CPBP family intramembrane metalloprotease SdpA	NA	NA	NA	NA
WP_001096494.1\|2400473_2401187_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091445.1\|2401444_2401747_+	hypothetical protein	NA	NA	NA	NA
WP_001200550.1\|2402002_2402368_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	6.2e-59	98.3
WP_000623473.1\|2402364_2402718_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	4.2e-20	77.8
WP_047213557.1\|2402967_2403801_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	3.5e-158	99.3
WP_000366163.1\|2404012_2404921_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	3.4e-138	100.0
WP_000933822.1\|2405045_2406239_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
WP_000109907.1\|2406610_2408203_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	99.8
WP_072357842.1\|2408497_2409244_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	1.3e-140	97.6
WP_000672018.1\|2409248_2409722_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	1.0e-82	97.5
WP_000718107.1\|2409787_2410045_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778513.1\|2410041_2411043_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	8.2e-186	97.3
WP_000348367.1\|2411047_2412526_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	6.9e-282	96.7
WP_072357839.1\|2412684_2413140_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	1.4e-79	98.6
WP_072357764.1\|2413442_2414093_+	calcium-binding protein	A0A2H4PQM8	Staphylococcus_phage	9.5e-34	67.6
WP_000070657.1\|2414174_2415170_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	2.9e-74	96.8
WP_047213559.1\|2415244_2415871_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	2.8e-75	92.4
WP_000627546.1\|2415911_2416253_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	3.0e-55	94.7
WP_047213562.1\|2416353_2416926_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	7.1e-25	93.1
WP_000864137.1\|2417123_2417681_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	2.0e-77	96.2
WP_000747794.1\|2418308_2418752_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000742593.1\|2419071_2419521_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_047213567.1\|2420156_2421347_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	1.5e-45	34.7
WP_000028660.1\|2421339_2422896_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	1.2e-287	99.2
WP_001038741.1\|2423259_2423979_-\|protease	serine protease SplF	A0A2H4PQP1	Staphylococcus_phage	4.0e-126	95.8
WP_001038864.1\|2424104_2424824_-\|protease	serine protease	A0A2H4PQP7	Staphylococcus_phage	2.4e-123	92.9
WP_001039451.1\|2424881_2425604_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	8.1e-127	95.8
WP_001092761.1\|2427390_2427969_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	1.5e-67	74.0
WP_025174462.1\|2428442_2428661_-	hypothetical protein	A0A2H4PQH0	Staphylococcus_phage	4.1e-26	83.3

DBSCAN-SWA_10

2542653 : 2616542

102

Staphylococcus_phage(89.19%)

holin,portal,tail,head,capsid,transposase,terminase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000827765.1\|2542653_2543820_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
WP_000434533.1\|2543850_2544177_+	staphostatin A	NA	NA	NA	NA
WP_000669861.1\|2544467_2544641_-	NETI motif-containing protein	NA	NA	NA	NA
WP_000011539.1\|2544621_2545224_-	DUF2179 domain-containing protein	NA	NA	NA	NA
WP_000040872.1\|2545492_2546314_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	7.9e-70	53.1
WP_000284433.1\|2546306_2547776_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	3.5e-108	45.1
WP_000897635.1\|2547959_2549036_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
WP_001177828.1\|2549055_2549850_+	prephenate dehydratase	NA	NA	NA	NA
WP_001802312.1\|2549921_2550029_+	hypothetical protein	NA	NA	NA	NA
WP_000323164.1\|2550039_2551602_-	SLC13 family permease	NA	NA	NA	NA
WP_000275712.1\|2551806_2552904_-	pectate lyase	U5PWM6	Bacillus_phage	1.5e-47	34.6
WP_000149686.1\|2553275_2553836_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
WP_001140871.1\|2553888_2554818_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
WP_001790680.1\|2555010_2555184_-	hypothetical protein	NA	NA	NA	NA
WP_042908133.1\|2555235_2556615_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_000181312.1\|2556734_2557763_-	lactonase family protein	NA	NA	NA	NA
WP_047213605.1\|2558033_2558426_+	YolD-like family protein	U3PG23	Staphylococcus_phage	2.9e-22	45.4
WP_000267034.1\|2558482_2558656_-	hypothetical protein	NA	NA	NA	NA
WP_001188066.1\|2559106_2560147_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_000713075.1\|2560203_2561046_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_001033968.1\|2561042_2561600_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000966288.1\|2561659_2562184_-	membrane protein	NA	NA	NA	NA
WP_000182842.1\|2562304_2562868_+	thioredoxin family protein	NA	NA	NA	NA
WP_001221656.1\|2562933_2563674_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
WP_047213607.1\|2563673_2564546_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	6.1e-28	35.2
WP_000645727.1\|2564542_2565223_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
WP_000991298.1\|2565223_2566120_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	1.1e-16	30.2
WP_000691584.1\|2566116_2566497_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000681972.1\|2566754_2566931_-	hypothetical protein	NA	NA	NA	NA
WP_000990056.1\|2567173_2567272_-	hypothetical protein	NA	NA	NA	NA
WP_001068524.1\|2567471_2568758_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_000671713.1\|2569028_2569319_-	MAP domain-containing protein	NA	NA	NA	NA
WP_046463167.1\|2569333_2570770_-	MAP domain-containing protein	NA	NA	NA	NA
WP_000669791.1\|2571727_2571907_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	1.4e-24	98.3
WP_001791826.1\|2572217_2572478_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_000702263.1\|2572529_2572880_-	complement inhibitor SCIN-A	A0A1P8L6B0	Staphylococcus_phage	7.5e-54	100.0
WP_165624923.1\|2573390_2573732_-	hypothetical protein	R9QTN8	Staphylococcus_phage	2.7e-56	94.7
WP_000920038.1\|2574376_2574868_-	staphylokinase	A0A1W6JQ12	Staphylococcus_phage	4.7e-86	99.4
WP_000861038.1\|2575058_2575814_-	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	3.4e-152	100.0
WP_000611512.1\|2575825_2576080_-\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
WP_031762631.1\|2576131_2576239_+	hypothetical protein	NA	NA	NA	NA
WP_072357969.1\|2576291_2576468_-\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	6.5e-22	96.6
WP_000340977.1\|2576610_2576985_-	hypothetical protein	G4KNR3	Staphylococcus_phage	3.3e-39	100.0
WP_001040255.1\|2577040_2577328_-	hypothetical protein	A0A075LZJ6	Staphylococcus_phage	5.8e-44	100.0
WP_000654329.1\|2577374_2577527_-	hypothetical protein	D2JLG0	Staphylococcus_phage	1.2e-19	98.0
WP_047213611.1\|2577516_2581302_-	phage minor structural protein	D2JLF9	Staphylococcus_phage	0.0e+00	98.7
WP_001154327.1\|2581317_2582808_-\|tail	phage tail protein	D2JLF8	Staphylococcus_phage	8.2e-299	100.0
WP_047213612.1\|2582807_2587292_-\|tail	phage tail tape measure protein	D2JLF7	Staphylococcus_phage	0.0e+00	95.7
WP_000570353.1\|2587347_2587470_-	hypothetical protein	D2JLF6	Staphylococcus_phage	6.9e-15	100.0
WP_000442602.1\|2587529_2587976_-	hypothetical protein	O80053	Staphylococcus_phage	1.9e-73	96.6
WP_000570652.1\|2588040_2588994_-\|tail	phage tail protein	A7TWD0	Staphylococcus_phage	6.2e-175	100.0
WP_000611452.1\|2588994_2589375_-	hypothetical protein	D2JLF3	Staphylococcus_phage	5.8e-68	100.0
WP_000501244.1\|2589371_2589749_-	HK97 gp10 family phage protein	D2JLF2	Staphylococcus_phage	1.1e-61	100.0
WP_000975314.1\|2589748_2590084_-\|head,tail	head-tail adaptor protein	A7TWC7	Staphylococcus_phage	1.1e-59	100.0
WP_001177483.1\|2590070_2590403_-\|head,tail	phage head-tail adapter protein	D2JLF0	Staphylococcus_phage	2.1e-58	100.0
WP_001252099.1\|2590411_2590570_-	hypothetical protein	D2JLE9	Staphylococcus_phage	3.2e-20	100.0
WP_000849950.1\|2590605_2591853_-\|capsid	phage major capsid protein	A7TWC4	Staphylococcus_phage	5.0e-209	100.0
WP_000032525.1\|2591940_2592525_-\|head,protease	HK97 family phage prohead protease	D2JLE7	Staphylococcus_phage	9.8e-107	100.0
WP_011447040.1\|2592517_2593708_-\|portal	phage portal protein	D2JLE6	Staphylococcus_phage	1.8e-224	100.0
WP_000644965.1\|2593773_2594013_-	membrane protein	A7TWC1	Staphylococcus_phage	7.0e-35	100.0
WP_000133304.1\|2593987_2595682_-\|terminase	phage terminase large subunit	D2JLE4	Staphylococcus_phage	0.0e+00	100.0
WP_000919026.1\|2595684_2596152_-\|terminase	phage terminase small subunit P27 family	D2JLE3	Staphylococcus_phage	1.1e-81	100.0
WP_000817289.1\|2596281_2596626_-	HNH endonuclease	D2JLE2	Staphylococcus_phage	4.2e-65	100.0
WP_000406191.1\|2596641_2597094_-	nucleoside triphosphate pyrophosphohydrolase family protein	D2JLE1	Staphylococcus_phage	1.4e-79	100.0
WP_000282747.1\|2597208_2597688_-	hypothetical protein	D2JLE0	Staphylococcus_phage	3.8e-72	100.0
WP_047213617.1\|2597710_2597911_-	DUF1514 family protein	A0A2I6PDV9	Staphylococcus_phage	3.1e-28	98.5
WP_000595240.1\|2597910_2598060_-	hypothetical protein	A0A1W6JPZ2	Staphylococcus_phage	4.1e-17	98.0
WP_000573772.1\|2598052_2598253_-	hypothetical protein	NA	NA	NA	NA
WP_000195827.1\|2598249_2598456_-	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.4e-20	76.5
WP_000185669.1\|2598492_2599029_-	hypothetical protein	R4IG63	Staphylococcus_phage	9.4e-96	100.0
WP_047213620.1\|2599021_2599270_-	DUF1024 family protein	A0A2K9VBU0	Staphylococcus_phage	2.0e-37	98.8
WP_047213622.1\|2599262_2599538_-	hypothetical protein	A0A0H4ISQ8	Staphylococcus_phage	1.2e-41	94.4
WP_047213624.1\|2599537_2599939_-	hypothetical protein	A0A0H4IPW3	Staphylococcus_phage	5.4e-56	81.3
WP_000131379.1\|2599953_2600196_-	hypothetical protein	A0A0F6N3E1	Staphylococcus_phage	1.9e-40	98.8
WP_047213626.1\|2600199_2600568_-	phage protein	I1W656	Staphylococcus_phage	3.1e-50	99.2
WP_001662398.1\|2600580_2600985_-	RusA family crossover junction endodeoxyribonuclease	O80087	Staphylococcus_phage	8.4e-73	100.0
WP_000338528.1\|2600993_2601212_-	hypothetical protein	A0A1P8L6E4	Staphylococcus_phage	1.4e-37	100.0
WP_047213628.1\|2601218_2602103_-	DnaD domain protein	I1W658	Staphylococcus_phage	1.9e-138	99.3
WP_000934769.1\|2602132_2602603_-	single-stranded DNA-binding protein	A0A0E3T9H6	Staphylococcus_phage	5.7e-81	100.0
WP_076692545.1\|2602603_2603206_-	MBL fold metallo-hydrolase	S4SWA4	Staphylococcus_phage	8.9e-87	100.0
WP_000138475.1\|2603301_2604222_-	recombinase	A0A2I6PDH5	Staphylococcus_phage	2.3e-166	100.0
WP_031763790.1\|2604223_2606167_-	AAA family ATPase	R9QT82	Staphylococcus_phage	0.0e+00	99.7
WP_001205732.1\|2606175_2606439_-	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	7.7e-43	100.0
WP_000291489.1\|2606447_2606708_-	DUF1108 family protein	A0A1W6JQ03	Staphylococcus_phage	7.6e-43	100.0
WP_000066020.1\|2606800_2606962_-	DUF1270 domain-containing protein	A0A2I6PDF7	Staphylococcus_phage	1.9e-20	100.0
WP_001120935.1\|2606958_2607279_-	DUF771 domain-containing protein	Q4ZDR7	Staphylococcus_virus	1.5e-56	100.0
WP_047213632.1\|2607337_2607565_+	hypothetical protein	A7TWL9	Staphylococcus_phage	1.1e-37	98.7
WP_000389906.1\|2607566_2607758_-	hypothetical protein	A7TWL8	Staphylococcus_phage	2.8e-26	100.0
WP_000768245.1\|2607807_2608164_+	DUF2513 domain-containing protein	A0A1P8L6H1	Staphylococcus_phage	6.1e-59	100.0
WP_001148853.1\|2608158_2608353_-	hypothetical protein	Q4ZDS1	Staphylococcus_virus	2.9e-23	98.4
WP_047213634.1\|2608368_2609118_-	oxidoreductase	Q8SDM9	Staphylococcus_phage	1.7e-135	99.2
WP_047213263.1\|2609174_2609387_+	hypothetical protein	A0A2H4JBA9	uncultured_Caudovirales_phage	1.6e-14	55.1
WP_000435357.1\|2609493_2609937_-	hypothetical protein	A7TWF2	Staphylococcus_phage	8.9e-76	100.0
WP_000213811.1\|2609984_2610197_-	helix-turn-helix transcriptional regulator	A7TWF1	Staphylococcus_phage	1.6e-30	100.0
WP_001566740.1\|2610348_2611080_+	helix-turn-helix transcriptional regulator	A0A075LYE4	Staphylococcus_phage	9.8e-88	75.8
WP_001049399.1\|2611091_2611247_+	hypothetical protein	A0A2I6PDR9	Staphylococcus_phage	6.3e-21	100.0
WP_001089804.1\|2611233_2611419_+	hypothetical protein	A0A2I6PDS4	Staphylococcus_phage	2.3e-25	100.0
WP_000705240.1\|2611618_2611801_+	hypothetical protein	A0A2I6PDR4	Staphylococcus_phage	5.3e-27	100.0
WP_001013104.1\|2611836_2611983_+	hypothetical protein	A0A2I6PEK8	Staphylococcus_phage	1.1e-14	89.6
WP_103225775.1\|2612394_2613961_+\|transposase	IS3-like element ISSau2 family transposase	A0A0C5AEA5	Paenibacillus_phage	1.7e-49	51.8
WP_047213639.1\|2614448_2615465_-	bi-component leukocidin LukGH subunit G	A0A1X9IGW5	Staphylococcus_phage	1.1e-25	30.2
WP_000791409.1\|2615486_2616542_-	bi-component leukocidin LukGH subunit H	A0A1X9IGW5	Staphylococcus_phage	1.9e-36	34.6

DBSCAN-SWA_11

2640242 : 2677341

Staphylococcus_phage(30.0%)

capsid,transposase,terminase,integrase,protease,tRNA

attL 2636813:2636830|attR 2660538:2660555

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2636813:2636830	attL	NA	NA	NA	NA
WP_000746372.1\|2640242_2640746_+\|transposase	transposase	NA	NA	NA	NA
WP_107399907.1\|2640726_2641263_+\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	9.9e-29	43.6
WP_168173448.1\|2641425_2642001_-	hypothetical protein	NA	NA	NA	NA
WP_000770704.1\|2641972_2642464_-	hypothetical protein	NA	NA	NA	NA
WP_103225780.1\|2642920_2643076_-\|terminase	terminase	Q4ZE85	Staphylococcus_phage	6.3e-21	94.0
WP_000253083.1\|2643072_2643564_-	hypothetical protein	A0A2H4JB26	uncultured_Caudovirales_phage	3.0e-24	39.9
WP_000657538.1\|2643746_2644805_-\|capsid	phage capsid protein	A0A0K2CZ99	Paenibacillus_phage	3.6e-14	26.6
WP_047213648.1\|2644791_2644998_-	hypothetical protein	NA	NA	NA	NA
WP_001081426.1\|2645222_2645567_-	hypothetical protein	A0A1W6JQD5	Staphylococcus_phage	5.5e-41	65.2
WP_047213650.1\|2646239_2648612_-	DNA primase	A0A2H4JCU9	uncultured_Caudovirales_phage	6.3e-136	39.4
WP_001103961.1\|2648703_2649003_-	DUF1474 family protein	Q4ZE75	Staphylococcus_phage	5.9e-31	66.7
WP_001058500.1\|2649003_2649228_-	hypothetical protein	A0A1W6JPA6	Staphylococcus_phage	2.9e-14	60.3
WP_162852000.1\|2649220_2649367_-	hypothetical protein	NA	NA	NA	NA
WP_000481975.1\|2649363_2649681_-	helix-turn-helix domain-containing protein	A0A1W6JQE0	Staphylococcus_phage	1.7e-49	96.2
WP_031774941.1\|2649694_2650336_-	Bro-N domain-containing protein	A0A2H4JB17	uncultured_Caudovirales_phage	7.8e-97	82.6
WP_000448766.1\|2650339_2650552_-	helix-turn-helix transcriptional regulator	A0A2H4JB11	uncultured_Caudovirales_phage	7.9e-06	45.5
WP_031774942.1\|2650705_2651368_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_031774943.1\|2651380_2652553_+\|integrase	site-specific integrase	A0A1W6JQD3	Staphylococcus_phage	1.5e-218	97.2
WP_047213652.1\|2652621_2654238_-	chaperonin GroEL	A0A240F779	uncultured_virus	1.2e-157	54.9
WP_031918283.1\|2654313_2654598_-	co-chaperone GroES	A0A221S386	uncultured_virus	3.6e-14	46.2
WP_000197641.1\|2654772_2655516_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000120321.1\|2655540_2656689_-	hypothetical protein	NA	NA	NA	NA
WP_000522380.1\|2656885_2657512_+	nitroreductase family protein	NA	NA	NA	NA
WP_000867953.1\|2657863_2658649_+	carbon-nitrogen family hydrolase	NA	NA	NA	NA
WP_000046023.1\|2659246_2659327_-	delta-hemolysin	NA	NA	NA	NA
WP_001105716.1\|2659617_2660181_+	accessory gene regulator AgrB	NA	NA	NA	NA
WP_001094303.1\|2660182_2660323_+	cyclic lactone autoinducer peptide	NA	NA	NA	NA
WP_072358013.1\|2660395_2661640_+	GHKL domain-containing protein	NA	NA	NA	NA
2660538:2660555	attR	NA	NA	NA	NA
WP_000688492.1\|2661658_2662375_+	response regulator transcription factor	A0A2H4J4Z6	uncultured_Caudovirales_phage	2.3e-25	32.6
WP_031927410.1\|2662446_2662554_+	hypothetical protein	NA	NA	NA	NA
WP_047213656.1\|2662741_2663701_-	carbohydrate kinase	NA	NA	NA	NA
WP_000141423.1\|2663697_2665182_-	sucrose-6-phosphate hydrolase	S6ATV4	Bacillus_phage	8.8e-19	25.6
WP_000790321.1\|2665330_2666281_-	LacI family transcriptional regulator	NA	NA	NA	NA
WP_001052272.1\|2666461_2667712_-	ammonium transporter	H8ZJB2	Ostreococcus_tauri_virus	2.4e-41	31.7
WP_000581074.1\|2667921_2668146_-	sulfurtransferase TusA family protein	NA	NA	NA	NA
WP_072358016.1\|2668205_2669234_-	YeeE/YedE family protein	NA	NA	NA	NA
WP_001283612.1\|2669590_2670226_-	redox-sensing transcriptional repressor Rex	NA	NA	NA	NA
WP_000602075.1\|2670478_2672407_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L0W2	Tupanvirus	9.3e-53	30.2
WP_001791590.1\|2672551_2672680_-	hypothetical protein	NA	NA	NA	NA
WP_000106319.1\|2672768_2674379_+	MutS family DNA mismatch repair protein	A0A0N9R0S5	Chrysochromulina_ericina_virus	1.3e-20	27.4
WP_000159047.1\|2674808_2675834_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	3.1e-63	40.9
WP_000372755.1\|2675826_2676291_-	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_001086751.1\|2676263_2676926_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	NA	NA	NA	NA
WP_014532666.1\|2676906_2677341_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NZ_CP026067.1|WP_000499194.1|1228025_1228181_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP026067.1|WP_000499194.1|1228025_1228181_+|hypothetical-protein

1228025_1228181_+

51 aa aa

1216699-1230892

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP026067_6	Orphan	6.1\|2621208\|34\|NZ_CP026067\|CRISPRCasFinder	2621208-2621241	34	1218546-1218513	1

1. spacer 6.1|2621208|34|NZ_CP026067|CRISPRCasFinder matches to NZ_CP026067 position: 1218546-1218513, mismatch: 1

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctttgttgg	Protospacer
*************************** ******

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP026067

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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