CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP011068	Streptococcus pyogenes strain STAB10015 chromosome, complete genome	4 crisprs	DinG,csm6,cas9,cas1,cas2,csn2,cas4,cas7,cas8c,cas5,cas3,DEDDh,csa3	0	7	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP011068_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011068_1

366280-366389

Orphan

Consensus_repeat	Method
ATCAGGATTTAGAAGGTACAGAACAGACAGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011068_1

>merge|NZ_CP011068|1|366280-366389|CRISPRCasFinder
ATCAGGATTTAGAAGGTACAGAACAGACAGATGGACAGGATGAGGATAAAAATAAAGAGTCTTCTGACCATTCTCGAAATCAGGATTTAGAAGGTACAGAACAGACAGAT

>NZ_CP011068|1|1|366280-366389|CRISPRCasFinder
ATCAGGATTTAGAAGGTACAGAACAGACAGAT	GGACAGGATGAGGATAAAAATAAAGAGTCTTCTGACCATTCTCGAA
ATCAGGATTTAGAAGGTACAGAACAGACAGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011068.1\|WP_011284563.1\|374021_374363_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_021340747.1\|367132_367369_+\|DUF2829-domain-containing-protein	unknown	unknown	gnl\|CDD\|378590
NZ_CP011068.1\|WP_011184238.1\|372350_372905_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239516
NZ_CP011068.1\|WP_011284554.1\|364165_364864_-\|streptococcal-pyrogenic-exotoxin-SpeJ	unknown	unknown	gnl\|CDD\|280949
NZ_CP011068.1\|WP_021340726.1\|365065_365203_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_002990820.1\|374461_375109_-\|metal-dependent-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224240
NZ_CP011068.1\|WP_011284545.1\|355531_356020_+\|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI	unknown	unknown	gnl\|CDD\|179603
NZ_CP011068.1\|WP_011284552.1\|363397_363898_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_011284560.1\|370937_372320_+\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl\|CDD\|184643
NZ_CP011068.1\|WP_011284544.1\|354514_355528_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|184425
NZ_CP011068.1\|WP_021340729.1\|372904_373156_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_011284557.1\|367361_368060_+\|3-oxoacyl-ACP-reductase	unknown	unknown	gnl\|CDD\|180617
NZ_CP011068.1\|WP_021340763.1\|358371_359124_-\|ADP-ribosyltransferase	unknown	unknown	gnl\|CDD\|238144
NZ_CP011068.1\|WP_021340750.1\|362773_363025_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_021340725.1\|362047_362521_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_011054229.1\|355986_358167_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|235952
NZ_CP011068.1\|WP_002993065.1\|369427_370765_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340903
NZ_CP011068.1\|WP_011284562.1\|373175_373871_+\|5'-methylthioadenosine/adenosylhomocysteine-nucleosidase	unknown	unknown	gnl\|CDD\|180148
NZ_CP011068.1\|WP_021340731.1\|359580_360033_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_021340734.1\|368135_369095_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745

Protein	Function_ID	Function_description	E-value
NZ_CP011068.1\|WP_021340747.1\|367132_367369_+\|DUF2829-domain-containing-protein	gnl\|CDD\|378590	pfam11195, DUF2829, Protein of unknown function (DUF2829). This is a uncharacterized family of proteins found in bacteria and bacteriphages.	7.94084e-26
NZ_CP011068.1\|WP_011184238.1\|372350_372905_+\|NUDIX-hydrolase	gnl\|CDD\|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	1.00316e-49
NZ_CP011068.1\|WP_011284554.1\|364165_364864_-\|streptococcal-pyrogenic-exotoxin-SpeJ	gnl\|CDD\|280949	pfam02876, Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain.	2.76111e-36
NZ_CP011068.1\|WP_011284545.1\|355531_356020_+\|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI	gnl\|CDD\|179603	PRK03600, nrdI, class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI.	3.10813e-78
NZ_CP011068.1\|WP_021340734.1\|368135_369095_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	2.0818e-53
NZ_CP011068.1\|WP_011284560.1\|370937_372320_+\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl\|CDD\|184643	PRK14354, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NZ_CP011068.1\|WP_011284544.1\|354514_355528_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta	gnl\|CDD\|184425	PRK13965, PRK13965, ribonucleotide-diphosphate reductase subunit beta; Provisional.	0
NZ_CP011068.1\|WP_011284557.1\|367361_368060_+\|3-oxoacyl-ACP-reductase	gnl\|CDD\|180617	PRK06550, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional.	4.49551e-162
NZ_CP011068.1\|WP_021340763.1\|358371_359124_-\|ADP-ribosyltransferase	gnl\|CDD\|238144	cd00233, VIP2, VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of biological pathways distinct from classical A-B toxins. A novel family of insecticidal ADP-ribosyltransferses were isolated from Bacillus cereus during vegetative growth, where VIP1 likely targets insect cells and VIP2 ribosylates actin. VIP2 shares significant sequence similarity with enzymatic components of other binary toxins, Clostridium botulinum C2 toxin, C. perfringens iota toxin, C. piroforme toxin, C. piroforme toxin and C. difficile toxin.	1.56597e-82
NZ_CP011068.1\|WP_002990820.1\|374461_375109_-\|metal-dependent-transcriptional-regulator	gnl\|CDD\|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	2.13047e-51
NZ_CP011068.1\|WP_011054229.1\|355986_358167_+\|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|235952	PRK07187, PRK07187, ribonucleoside-diphosphate reductase subunit alpha.	0
NZ_CP011068.1\|WP_011284562.1\|373175_373871_+\|5'-methylthioadenosine/adenosylhomocysteine-nucleosidase	gnl\|CDD\|180148	PRK05584, PRK05584, 5'-methylthioadenosine/adenosylhomocysteine nucleosidase.	7.28883e-124
NZ_CP011068.1\|WP_002993065.1\|369427_370765_+\|MFS-transporter	gnl\|CDD\|340903	cd17345, MFS_GlpT, Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters. Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.18637e-158

>NZ_CP011068.1|WP_021340726.1|365065_365203_-|hypothetical-protein
MLTYHELKKAVANRYIKGDMISITRKLVSSLILSFLIELYEYQEF
>NZ_CP011068.1|WP_011284554.1|364165_364864_-|streptococcal-pyrogenic-exotoxin-SpeJ
MKRLIKTIILVIIIFHGYGSVKSDSEKIKDVKLQLNYAYEIRPVDYTNCNIDYLTTHDFYIDVSSYKKKNFSVDSEVESYITTKFTKNQKVNIFGLPYIFTRYDVYYIYGGVTPSVNSNSENSKIVGNLLIDGVQQKTLINPIKIDKRIFTIQEFDFKIRQYLMQTYKIYDPNSPYIKGQLEIAINGNKHESFNLYDATSSSTRSDIFKKYKDNKTINMKDFSHFDIYLWTK
>NZ_CP011068.1|WP_011284552.1|363397_363898_-|hypothetical-protein
MKKTLTLLLALFTIGVTSSVRAEESSWVPLPRQQKVLDDNRNEIPVHITGNKVTVTLPPGWSAWIDKNTKQRNSNSVTTTVTLDISTSQPPKEFTIYFQGDDGFLAGMMTFIDSETLKNEQYKAFDEEYAENLFENSRLREEQKTWRDKVRDVFQDAWWNFKGLFQ
>NZ_CP011068.1|WP_021340750.1|362773_363025_+|hypothetical-protein
MPEKKVLPVLSMVVSFVCLLDHIFFFATYSYLYLPLVASSLALISLVQNKGRQKVWSLAGLILAALAVAVVAYAYYDPTVIPY
>NZ_CP011068.1|WP_021340725.1|362047_362521_+|hypothetical-protein
MKTKSKRFLNLATLCLALLGTTLLMGQPIKAEAVVSDLNDAVSSMGDTAEETDVNIDGQEDEEDEEDDAYMQGRRLGEKEGYEAGQKDNAPRLFDSSTLEPPTNPYEDAGDTLNSNWFKSGYSDAYGQAYEQGWNDTHPIQSTLIWLWGIVRNLFRF
>NZ_CP011068.1|WP_021340731.1|359580_360033_+|hypothetical-protein
MKTKSKRFLNLATLCLALLGTTLLMTRPVKAEVSEIGHDHVTISSNGQTDEGAAYGRGHDDGSKFGYEAGLQSSWNESEPPSSDKIPEPSVNPYESSNEQDREDYKEGFRDGYPGGYVAGWRKTHPIEATLQYLWYTVSSWFESLFNNSK
>NZ_CP011068.1|WP_021340763.1|358371_359124_-|ADP-ribosyltransferase
MLKKRYQLAMILLLSCFSLVWQTEGLVELFVCEHYERAVCEGTPAYFTFSDQKGAETLIKKRWGKGLVYPRAEQEAMAAYTCQQAAPINTSLDKTKGELSQLTPELRDQVAQLDAATHRLVIPWNIVVYRYVYETFLRDIGVSHADLTSYYRNHQFDPHILCKIKLGTRYTKHSFMSTTALKNGAMTHRPVEVRICVKKGAKAAFVEPYSAVPSEVELLFPRGCQLEVVGAYVSQDQKKLHIEAYFKGSL
>NZ_CP011068.1|WP_011054229.1|355986_358167_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-alpha
MSQTNASYLSLNALTRFKKPDGSYHFDSDKEAVRRYLEEHVSPNQMAFNSLEDKLAYLINEGYYEQAIFDAYPNDLIKEAFHYAYQQGYRFLNLMGAMKFYQSYALKTLDGKQYLETFEDRAVMNALFLADGDQTFVFDVIDAILHRRFQPATPTFLNAGKKRRGEYISCYLLRVEDNMESISRAISTSLQLSKRGGGVALCLTNLREIGAPIKGIENQATGIVPVMKLLEDSFSYANQLGQRQGAGAVYLHAHHPEVLTFLDTKRENADEKIRIKSLALGLVIPDITFQLAKENKDMALFSPYDIKRAYGKDMSDISITEEYDKLLANPAIKKTYISARKFFQLIAELHFESGYPYLLFDDTVNKRNPHAKKGRIVMSNLCSEIAQVSTPSTFKEDLSFETIGEDICCNLGSINIAQAMADAPHFEQLITTSIRALDRVSRVSDLNCAPSVETGNAANHAVGLGAMNLHGFLATNHIYYDTKEAVDFTDLFFHAMAYYAFKASCQLAKEKGAFAGFSLSTYADGTYFAKYLQEDAKPQTAKVATLLQDYGFTLPTVADWQALVADIKQFGLANAHLLAVAPTGSISYLSSCTPSLQPVVAPVEVRKEGSLGRIYVPAYQIDQANYAYYERGAYEVGPKAIIDVVAAAQKHVDQAISLTLFMTDQATTRDLNRSYIQAFKQNCASIYYVRVRQDVLAGSEQYDEDSLVTAPGASDETTTECQSCMI
>NZ_CP011068.1|WP_011284545.1|355531_356020_+|class-Ib-ribonucleoside-diphosphate-reductase-assembly-flavoprotein-NrdI
MAELIIVYFSSKSNNTHRFVQKLGLPAQRIPVDNRPLEVSTHYLLIVPTYAAGGSDAKGAVPKQVIRFLNNPNNRKHCKGVISSGNTNFGDTFALAGPIISQKLQVPLLHQFELLGTATDVKKVQAIFARLKHHTHDKQKQINNLITERTHPCHKPMRHTSH
>NZ_CP011068.1|WP_011284544.1|354514_355528_+|class-1b-ribonucleoside-diphosphate-reductase-subunit-beta
MTQHYYERSQSPIEYALSETQKQLRSINWNYLNDDKDLEVWNRVTQNFWLPEKVPVSNDLNSWRSLGEDWQQLITRTYTGLTLLDTVQATVGDVAQIQHSQTDHEQVIYTNFAFMVGIHARSYGTIFSTLCSSEQIEEAHEWVVSTQSLQDRSRVLIPYYTGDDPLKSKVAAAMMPGFLLYGGFYLPFYLSARGKMPNTSDIIRLILRDKVIHNYYSGYKYQQKVARLSPEKQAEMKAFVFDLLYELIDLEKAYLRELYAGFDLAEDAIRFSLYNAGKFLQNLGYDSPFTDEETRISPEVFAQLSARADENHDFFSGNGSSYVMGITEETTDDDWEF
>NZ_CP011068.1|WP_021340747.1|367132_367369_+|DUF2829-domain-containing-protein
MTFEEILPGLKAKKKYVRTGWGGAENYVQLFDTLEVDGKVLQATPYFLIHVTGEGEGFSMWAPTPCDVLAEDWIEVND
>NZ_CP011068.1|WP_011284557.1|367361_368060_+|3-oxoacyl-ACP-reductase
MTKVVLVTGCASGIGYAQARYFLRQGYHVYGVDKSDKPDLSGNFHFIKLDLSSELSPLFKVVPSVDILCNTAGILDAYKPLLDVSDEEVEHLFDINFFATVKLTRHYLRRMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQIHIFGIAPGAVKTAMTASDFEPGGLAEWVARETPIGRWTEPDEVAELTGFLASGKARSMQGEIVKIDGGWTLK
>NZ_CP011068.1|WP_021340734.1|368135_369095_+|Gfo/Idh/MocA-family-oxidoreductase
MKLAVLGTGMIVKEVLPVLQKIDGIDLVAILSTVRSLKTAKDLAKAYHMPLATSEYEAVLGNEEIDTVYIGLPNHLHFAYAKEALLAGKHVICEKPFTMTAGELDELVVIAKKRKLILLEAITNQYLNNMTFIKEHLDQLGDIKIVECNYSQYSSRYDVFKRGDIAPAFNPKMGGGALRDLNIYNIHFVVGLFGRPKTVQYLANVEKGIDTSGMLVMDYEQFKVVCIGAKDCTAEIKTTIQGNKGSLAVLGATNTLPQVQLSLHGHEAQVVNHNKYDHRMYEEFVAFRDMIDQRDFEKVNQALEHSRAVMAVLERAVHS
>NZ_CP011068.1|WP_002993065.1|369427_370765_+|MFS-transporter
MEEDYNKREPEKFTQFLRRQKVVFFVAFFGYVCAYLVRNNFKLMSNTIMVQNGWDKAQIATLLSCLTVSYGLAKFYMGALGDRVSLRKLFSISLGASALICILIGFFNSSMVVLGILLVLCGVVQGALAPASQAMIANYFPNKTRGGAIAGWNISQNMGSALLPLTIALLTSMGLVVPANGNILLAFLIPGVLVFLFALCCWKLGGDNPESEGLDSLRTMYGDAGESAVASEEEKHNLSYWQLIWKYVFCNPSLLLVAAVNVALYFVRFGIEDWMPIYLSQVANMSEAHIHFAISMLEWVAIPGSLVFAWLAVRYPNKMAKIGAIGLFVLAAIVFVYERLTATGAPNYFLLLVIAGILGSLIYGPQLIVNILTINFVPLNVAGTAIGFVGVTAYLIGNMGANWLMPILADGFGWFWSYIVVAALSAFSAVGYLILAKREEEIIKD
>NZ_CP011068.1|WP_011284560.1|370937_372320_+|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MTNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAISPEKSVTVIGHKSEMVRAVLADQSAFVHQTEQLGTGHAVMMAETQLEGLEGHTLVIAGDTPLITGESLKSLIDFHVNHKNVATILTATAQDPFGYGRIVRNKDGEVIKIVEQKDANEYEQQLKEINTGTYVFDNKRLFEALKCITTNNAQGEYYLTDVVTIFRANKEKVGAYILRDFNESLGVNDRVALATAETVMRQRITQKHMVNGVTFQNPETVYIESDVEIAPDVLIEGNVTLKGRTHIGSGTVLTNGTYIVDSEIGDNCVVTNSMIESSVLAAGVTVGPYAHLRPGTTLDREVHIGNFVEVKGSHIGEKTKAGHLTYIGNAQVGSSVNVGAGTITVNYDGQNKYETVIGDHAFIGSNSTLIAPLEVGDHALTAAGSTISKTVPIDSIAIGRSRQVTKEGYAKRLAHHPSRSK
>NZ_CP011068.1|WP_011184238.1|372350_372905_+|NUDIX-hydrolase
MKFEEKTLKRQTVFDGHIFKVVVDDVELPNNLGQSKRELIFHRGAVAVLAITPERKILLVKQYRKAIERVSYEIPAGKLEIGEEGSKLKAAARELEEETAYTGTLTFLYEFYTAIGFCNEKITLFLATDLTQVANPKPQDDDEVIEVLELTYQECMDLVAQGKLADAKTLIALQYYALHFGGEQ
>NZ_CP011068.1|WP_021340729.1|372904_373156_+|hypothetical-protein
MGRPLLTDDIIEKARRMETFESDDAVDFDTKVMTLPEKDDKARIYKSRRIENAKRSQLQSKLNVILIAVMLLIAILVYAIFYL
>NZ_CP011068.1|WP_011284562.1|373175_373871_+|5'-methylthioadenosine/adenosylhomocysteine-nucleosidase
MKIGIIAAMEEELSLLLANLLDAQEHQVLSKTYYTGRFGKHELILVQSGVGKVMSAMTVAILVEHFKAQAIINTGSAGAVASHLAIGDVVVADRLVYHDVDATAFGYAYGQMAGQPLYYDCDPQFVAIFKQVLKHEKTNGQVGLIATGDSFVAGQDKIDQIKTAFSDVLAVEMEGAAIAQAAHTAGKPFIVVRAMSDTAAHDANITFDQFIIEAGKRSAQILMTFLENLPV
>NZ_CP011068.1|WP_011284563.1|374021_374363_+|hypothetical-protein
MTLKKHYYLLSLLALVTVGAAFNTSQSVSAQVYSNGRYRQGLTDEKSKLQYSKDNAKLQLRNILNGYQSDLGRHYSSYYYYNLRTVMGLSKEQEIEKYYEELKNKLHDMYNHY
>NZ_CP011068.1|WP_002990820.1|374461_375109_-|metal-dependent-transcriptional-regulator
MTPNKEDYLKCIYEIGEQEPKITNKMVAEKMHVSAPAVSEMIKKMISQGWIVKDKAKGYLLKDKGYALVANLYRKHRLIEVFLIHQLGYNTQEVHQEAEVLEHTVSDTFIDRLDKILDFPDFCPHGGTIPRYGQPLVEMNTTTLNTITELGRFRLSRIHDHFDLIQYLEAHHLSINTELTLTQIDTFAKTYTICYGDKELVIPENIAKQLYVTAL

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Crispr_ID: NZ_CP011068_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011068_2

776961-777260

TypeII

II-A

Consensus_repeat	Method
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	PILER-CR
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	CRISPRCasFinder
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	CRT

4 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_CP011068_2

>merge|NZ_CP011068|2|776961-777260|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAACTGCTCCAGATGGATTTTTAAACTGATTATTGTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAACTAGAAATTGACAATGCTTTTTCTTTTGTCTGTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAACAATAGAGCTAGACAAAAAATTGAGTTTGACGTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAACGACATATTAACGTCCTTTCTCCTGCTTTCCGTTTTAGAGCTATGCTGTTTTGAATGGTCTCCATTC

>NZ_CP011068|2|1|776961-777194|PILER-CR
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	TGCTCCAGATGGATTTTTAAACTGATTATT
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	TAGAAATTGACAATGCTTTTTCTTTTGTCT
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	AATAGAGCTAGACAAAAAATTGAGTTTGAC
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC

>NZ_CP011068|2|2|776961-777260|CRISPRCasFinder
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	TGCTCCAGATGGATTTTTAAACTGATTATT
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	TAGAAATTGACAATGCTTTTTCTTTTGTCT
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	AATAGAGCTAGACAAAAAATTGAGTTTGAC
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	GACATATTAACGTCCTTTCTCCTGCTTTCC
GTTTTAGAGCTATGCTGTTTTGAATGGTCTCCATTC

>NZ_CP011068|2|1|776961-777260|CRT
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	TGCTCCAGATGGATTTTTAAACTGATTATT
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	TAGAAATTGACAATGCTTTTTCTTTTGTCT
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	AATAGAGCTAGACAAAAAATTGAGTTTGAC
GTTTTAGAGCTATGCTGTTTTGAATGGTCCCAAAAC	GACATATTAACGTCCTTTCTCCTGCTTTCC
GTTTTAGAGCTATGCTGTTTTGAATGGTCTCCATTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011068.1\|WP_002984851.1\|769815_770448_+\|TIGR01906-family-membrane-protein	unknown	unknown	gnl\|CDD\|226884
NZ_CP011068.1\|WP_004218788.1\|769051_769816_+\|TIGR01457-family-HAD-type-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP011068.1\|WP_047715998.1\|777408_778542_+\|ISAs1-like-element-IS1548-family-transposase	unknown	unknown	gnl\|CDD\|227720
NZ_CP011068.1\|WP_011184463.1\|764976_766332_+\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237670
NZ_CP011068.1\|WP_011284751.1\|786632_788282_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NZ_CP011068.1\|WP_011284749.1\|782118_782556_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|234692
NZ_CP011068.1\|WP_002989943.1\|778710_780543_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP011068.1\|WP_002989931.1\|785669_786497_+\|PTS-mannose/fructose/sorbose-transporter-family-subunit-IID	unknown	unknown	gnl\|CDD\|226239
NZ_CP011068.1\|WP_011284744.1\|768299_769052_+\|acyl-[acyl-carrier-protein]-thioesterase	unknown	unknown	gnl\|CDD\|226401
NZ_CP011068.1\|WP_011284750.1\|782685_783705_+\|YeiH-family-putative-sulfate-export-transporter	unknown	unknown	gnl\|CDD\|225411
NZ_CP011068.1\|WP_002984845.1\|784355_784847_+\|PTS-system-mannose/fructose/N-acetylgalactosamine-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|225976
NZ_CP011068.1\|WP_002984846.1\|783911_784337_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|225446
NZ_CP011068.1\|WP_011284745.1\|770892_774999_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226044
NZ_CP011068.1\|WP_002984836.1\|788285_789074_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|227095
NZ_CP011068.1\|WP_002989951.1\|775864_776206_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_CP011068.1\|WP_011284742.1\|766455_767097_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_002989949.1\|776195_776858_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd09758_csn2_CAS-II-A	gnl\|CDD\|213408
NZ_CP011068.1\|WP_002984844.1\|784863_785673_+\|PTS-mannose/fructose/sorbose/N-acetylgalactosamine-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226238
NZ_CP011068.1\|WP_002989953.1\|774998_775868_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NZ_CP011068.1\|WP_021340475.1\|767159_768290_+\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309

Protein	Function_ID	Function_description	E-value
NZ_CP011068.1\|WP_002984851.1\|769815_770448_+\|TIGR01906-family-membrane-protein	gnl\|CDD\|226884	COG4478, COG4478, Predicted membrane protein [Function unknown].	1.04206e-87
NZ_CP011068.1\|WP_004218788.1\|769051_769816_+\|TIGR01457-family-HAD-type-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.84127e-128
NZ_CP011068.1\|WP_047715998.1\|777408_778542_+\|ISAs1-like-element-IS1548-family-transposase	gnl\|CDD\|227720	COG5433, COG5433, Transposase [DNA replication, recombination, and repair].	1.29021e-30
NZ_CP011068.1\|WP_011184463.1\|764976_766332_+\|phosphoglucosamine-mutase	gnl\|CDD\|237670	PRK14316, glmM, phosphoglucosamine mutase; Provisional.	0
NZ_CP011068.1\|WP_011284749.1\|782118_782556_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|234692	PRK00222, PRK00222, peptide-methionine (R)-S-oxide reductase MsrB.	5.00558e-84
NZ_CP011068.1\|WP_002989949.1\|776195_776858_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213408	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	3.6851e-120
NZ_CP011068.1\|WP_002989931.1\|785669_786497_+\|PTS-mannose/fructose/sorbose-transporter-family-subunit-IID	gnl\|CDD\|226239	COG3716, ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism].	1.55707e-109
NZ_CP011068.1\|WP_011284744.1\|768299_769052_+\|acyl-[acyl-carrier-protein]-thioesterase	gnl\|CDD\|226401	COG3884, FatA, Acyl-ACP thioesterase [Lipid metabolism].	9.21279e-109
NZ_CP011068.1\|WP_011284750.1\|782685_783705_+\|YeiH-family-putative-sulfate-export-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	3.12379e-103
NZ_CP011068.1\|WP_002984845.1\|784355_784847_+\|PTS-system-mannose/fructose/N-acetylgalactosamine-transporter-subunit-IIB	gnl\|CDD\|225976	COG3444, COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB [Carbohydrate transport and metabolism].	2.00329e-54
NZ_CP011068.1\|WP_002984846.1\|783911_784337_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|225446	COG2893, ManX, Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism].	1.16501e-30
NZ_CP011068.1\|WP_011284745.1\|770892_774999_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|226044	COG3513, COG3513, Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms].	0
NZ_CP011068.1\|WP_002984836.1\|788285_789074_+\|response-regulator-transcription-factor	gnl\|CDD\|227095	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms].	5.79862e-82
NZ_CP011068.1\|WP_011284751.1\|786632_788282_+\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	7.60374e-78
NZ_CP011068.1\|WP_002989951.1\|775864_776206_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	4.79e-58
NZ_CP011068.1\|WP_002989943.1\|778710_780543_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP011068.1\|WP_002984844.1\|784863_785673_+\|PTS-mannose/fructose/sorbose/N-acetylgalactosamine-transporter-subunit-IIC	gnl\|CDD\|226238	COG3715, ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism].	3.81104e-76
NZ_CP011068.1\|WP_002989953.1\|774998_775868_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.48912e-131
NZ_CP011068.1\|WP_021340475.1\|767159_768290_+\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0

>NZ_CP011068.1|WP_002989949.1|776195_776858_+|type-II-A-CRISPR-associated-protein-Csn2
MNLNFSLLDEPIPLRGGTILVLEDVCVFSKIVQYCYKYEEDSELKFFDRKMKTIKESEIMLVTDILGFDVNSSTILKLIHADLESQFNEKPEVKSMIDKLVATITELIVFECLENELDLEYDEITILELIKSLGVKVETQSDTIFEKCLEILQIFKYLTKKKLLIFVNSGAFLTKDEVASLQEYISLTNLTVLFLEPRELYDFPQYILDEDYFLITKNMV
>NZ_CP011068.1|WP_002989951.1|775864_776206_+|CRISPR-associated-endonuclease-Cas2
MSYRYMRMILMFDMPTDTAEERKAYRKFRKFLLSEGFIMHQFSIYSKLLLNNTANNAMIGRLREHNPNKGNITLLTVTEKQFARMIYLHGERNNCIANSDERLVFLGEAFDES
>NZ_CP011068.1|WP_002989953.1|774998_775868_+|type-II-CRISPR-associated-endonuclease-Cas1
MAGWRTVVVNTHSKLSYKNNHLIFKDAYKTELIHLSEIDILLLETTDIVLSTMLVKRLVDENVLVIFCDDKRLPTAMLMPFYGRHDSSLQLGKQMSWSETVKSQVWTTIIAQKILNQSCYLGACSYFEKSQSIMDLYHGLENFDPSNREGHAARIYFNTLFGNDFSRDLEHPINAGLDYGYTLLLSMFAREVVVSGCMTQFGLKHANQFNQFNFASDIMEPFRPLVDKIVYENRNQPFPKIKRELFTLFSDTFSYNGKEMYLTNIISDYTKKVVKALNNEGKGVPEFRI
>NZ_CP011068.1|WP_011284745.1|770892_774999_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MDKKYSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRLNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLAKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFIKDDSIDNKVLTRSDKNRGKSNNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVRKDLIVKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATFIHQSITGLYETRIDLSQLGGD
>NZ_CP011068.1|WP_002984851.1|769815_770448_+|TIGR01906-family-membrane-protein
MVENTKLLCSWVWLLALAILITIYSTWLWYPLEVDHLKLEQVVFMSKDAILHNYNGLLNYLTNPFVTRLEFANFHSSADGLKHFADVKWLFHLTQVVFLGLLYPTLKTFTQRLKTKRFWLLQKPLILAALFPLMIGLMASFIGFEHFFTLFHQVLFVGDSSWLFDPLKDPVIWILPEVFFLHCFLFFMIVYEIILWSLVGLARWQRLNVE
>NZ_CP011068.1|WP_004218788.1|769051_769816_+|TIGR01457-family-HAD-type-hydrolase
MPYKGYLIDLDGTIYQGKNRIPAGERFIKRLQERGIPYLLVTNNTTRTPEMVQSMLANQFHVETGIETIYTATMATVDYMNDMNRGKTAYVIGETGLKSAIAAAGYVEELENPAYVVVGLDSQVTYEMLAIATLAIQKGALFIGTNPDLNIPTERGLMPGAGALNALLEAATRVKPVFIGKPNAIIMNKSLEVLGIQRSEAVMVGDNYLTDIMAGIQNDIATILVTTGFTRPEEVPTLPIQPDHVLSSLDEWRL
>NZ_CP011068.1|WP_011284744.1|768299_769052_+|acyl-[acyl-carrier-protein]-thioesterase
MGLSYQEELTLPFELCDVKSDIKLPLLLDYCLMVSGRQSAQLGRSNNNLLVDYKLVWIVTDYEITIHRLPHFQETITIETKALSYNKFFCYRQFYIYDQEGGLLVDILAYFALLNPDTRKVATIPEDLVAPFKTDFVKKPHRVPKMPLLEQSIDRDYYVRYFDIDMNGHVNNSKYLDWMYDVLGCEFLKTHQPLKMTLKYVKEVSPGGQITSSYHLDQLTSYHQITSDGQLNAQAMIEWRAIKQTESETD
>NZ_CP011068.1|WP_021340475.1|767159_768290_+|oxygen-independent-coproporphyrinogen-III-oxidase
MSKKPTSAYVHIPFCTQICYYCDFSKVFIQNQPVDAYLKALIQEFDSYGIRDLKTLYIGGGTPTAITAKQLEYLLNHLERNLNLDDLEEFTIEANPGDLTPEKIAVLQRSAVNRISLGVQTFNNKQLKQIGRSHNEEQIYSTIANLKTAGFHNISIDLIYALPGQTLDQVKENVAKALALDIPHLSLYSLILEHHTVFMNKMRRGKLNLPTEDLEAEMFEYIISEMEANGFEHYEISNFTKPGFESRHNLMYWDNVEYFGCGAGASGYLNGIRYQNRVPIQHYLKAVEAGNARLNEEVLRKEEMMEEELFLGLRKKTGVSIQRFQEKFGVSFEERYGNIVRELQNQGLLVKDDAFVRMTKKGLFLGDSVAERFILD
>NZ_CP011068.1|WP_011284742.1|766455_767097_+|hypothetical-protein
MTKQQIEKLADLLPPFAATLYLDMIPEFQEGYASYVYQTPKQDIQKRRIKQLTKNFERLLDTPSFYVMPVTRKTAEQLLADKGLAYHLLSTVAANQVFAAAVNEDQTLFQVLRNGARVAFVILQEKGEFLEMTLGILETVTENEVPAAIVEAVQTYLLADMQENLPSLSIMVSQESSKLFYQEQGFVLLAKGCKPGNENDSDVCQLVKYFSRP
>NZ_CP011068.1|WP_011184463.1|764976_766332_+|phosphoglucosamine-mutase
MGKYFGTDGVRGEANVELTPELAFKLGRFGGYVLSQHETERPKVFVARDTRISGEMLESALIAGLLSVGIEVYKLGVLATPGVSYLVRTEKASAGVMISASHNPALDNGIKFFGNDGFKLADDQELEIEALLDAPEDTLPRPSAEGLGTLVDYPEGLRKYEKFLVTTGTDLSGMTVALDTANGAASVSARDVFLDLNAEIAVIGEKPNGLNINDGVGSTHPEQLQELVKETGADLGLAFDGDSDRLIAVDETGEIVDGDRIMFIIGKYLSEKGLLAHNTIVTTVMSNLGFHKALDKQGINKAITAVGDRYVVEEMRSSGYNLGGEQSGHVIIMDYNTTGDGQLTAIQLAKVMKETGKSLSELAAEVTIYPQKLVNIRVENSMKDRAMEVPAIANIIAKMEDEMAGNGRILVRPSGTEPLLRVMAEAPTDAEVDYYVDTIADVVRTEIGCDN
>NZ_CP011068.1|WP_047715998.1|777408_778542_+|ISAs1-like-element-IS1548-family-transposase
MIDFIISIDDCAVELDSRQSWKIGYPLSTILFLVFVCQLAGIETWKEMEDFIEMNEPLFATYVDLSEGCPSHDTLERVISLVNTDRLKELKVQFEQSLTSLDAVHQLISVDGKTIRGNRGKNQKPVHIVTAYDGGHHLSLGQVAVEEKSNEIVAIPQLLRTIDIRKSIVTIDAMGTQTAIVDTIIKGKADYCLAVKGNQETLYDDIALYFSDVNLLEELQENAQYYQTVEKSRGQIEVREYWVSSDIKWLCQNHPKWHKLRGIGMTRNTIDKDGQLSQENRYFIFSFKPDVLTFANCVRGHWQIESMHWLLDVVYHEDHHQTLDKRAAFNLNFIRKMCLYFLKVMVFPKKDLSYRRKQRYISVHLEDYLVQLFGERG
>NZ_CP011068.1|WP_002989943.1|778710_780543_+|elongation-factor-4
MNSQDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRHEVEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVDAPLQALIFDSVYDAYRGVILQVRIVNGIVKPGDKIQMMSNGKTFDVTEVGIFTPKAVGRDFLATGDVGYVAASIKTVADTRVGDTVTLANNPAKEALHGYKQMNPMVFAGIYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVHTTDEDMIEVSNPSEFPDPTRVAFIEEPYVKAQIMVPQEFVGAVMELSQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYDMSEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKIIVEKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDAKK
>NZ_CP011068.1|WP_011284749.1|782118_782556_+|peptide-methionine-(R)-S-oxide-reductase-MsrB
METSDELKQRIGDLSYEVTQHAATESPFTGEYDNFFEKGIYVDIVSGEVLFSSLDKFNSGCGWPAFSKPIENRMVTNHDDSSYGMRRVEVKSREAGSHLGHVFSDGPKEAGGLRYCINSAALKFIPYEQMEKEGYAQWLTLFDET
>NZ_CP011068.1|WP_011284750.1|782685_783705_+|YeiH-family-putative-sulfate-export-transporter
MSTHLRKLPGLLLCLLLALPAWYLGRLFPIIGAPVFAILLGMLLALFYHHRDKAKEGISFTSKYILQTAVVLLGFGLNLTQVMAVGMQSLPIIISTIATALLVAYGSQKWLRLDVNTATLVGVGSSICGGSAIAATAPVIKAKDDEVAKAISVIFLFNMLAALLFPSLGQLLGLSNDGFATFAGTAVNDTSSVTATATAWDALHHSNTLDDATIVKLTRTLAILPITLGLSLYRAKKEHDIVTEENFSLRKSFPRFILFFLLASLITTLMTSFGVSADVFHSLKTLSKFFIVMAMAAIGLNTNLVKLIKTGGQAILLGAICWVAITLVSLAMQLSLGIW
>NZ_CP011068.1|WP_002984846.1|783911_784337_+|PTS-sugar-transporter-subunit-IIA
MKRKFLIGSHGRLASGLQSSIDILAGMGQALETIDAYVDDSDYTSQIDNFIAGVAADEQGLIFTDLLGGSVNQKMVTAVMNSGKDNIFLITNSNLATLLSLVFLKPGEALTKDDIVTVINESQVQLVDLVPETNSEDDFFD
>NZ_CP011068.1|WP_002984845.1|784355_784847_+|PTS-system-mannose/fructose/N-acetylgalactosamine-transporter-subunit-IIB
MITQIRVDDRLIHGQVAVVWTKELNAPLLVVANDEAAKNEITQMTLKMAVPNGMKLLIRSVEDSIKLFNDPRAKDKRIFVIVNSVKDACAIAKEVPDLEAVNVANVGRFDKSDPASKVKVTPSLLLNPEEMAAAKELVSLPELDVFNQVLPSNTKVHLSQLVN
>NZ_CP011068.1|WP_002984844.1|784863_785673_+|PTS-mannose/fructose/sorbose/N-acetylgalactosamine-transporter-subunit-IIC
MLVPATMAALAVLICFGGNYLTGQSMMERPLVVGLVTGLLLGDMKVGILMGASLEALFLGNVNIGGVIAAEPVTATAMATTFTIISHIDQKAAMTLAVPIGMLAAFVVMFLKNVFMNIFAPMVDKAAAANHQGKLVMLHYGTWIIYYLIIASISFIGILVGSGPVNAFVEHIPQNLMNGLSAAGGLLPAVGFAMLMKLLWTNKLAVFYLLGFVLTAYLKLPAVAVAALGAVICVISSQRDLELDAITRGAISKQTTFDSKESEEEDFFA
>NZ_CP011068.1|WP_002989931.1|785669_786497_+|PTS-mannose/fructose/sorbose-transporter-family-subunit-IID
MTSQDNLTKEDRKMLRSVFWRSWTMNASRTGATQYHAVGVIYTLLPVINRFYKTDKDKAEALVRHTTWFNATMHINNFIMGLVASMEKKNSEDPDFDASAITAVKASLMGPISGVGDSFFWGILRVIAAGIGISLASAGSAMGAVVFLLLYNIPAFIIHYYSLYGGYSVGAGFIKKLYESGGIKIVTKTSSMLGLMMVGSMTASNVKFKTILTVAAKGAKEAASIQDYLDQLFIGIVPLMVTLAAFWLLRKKVNINWIMFGIMFLGIILGLLGIC
>NZ_CP011068.1|WP_011284751.1|786632_788282_+|sensor-histidine-kinase
MRGEQVEEHFKKQLQDDISRHFSYQSLMLSLLLIGLFIIFSLAPQQLGLYRDINATATRYHRLISKQEALLDDLGKNSLLPFLNKNLSTADLSKHYFHLRHSSQTSPELLLFSPSQDLLFASNPHLGNVFSKSVYIQEVLRAAHPPKTLFKVAMDSEDGHYLMIIKPMIDQNQLKGYAFLVMSGKDFLHPTKTLTSELVIADKLDNTFTFSNREFIASSLDKINSQYLHHYFVFQDNRAFITRKVALQGGLWLYMYRPLIPMVSVMLFSLISSAVIFVILQRKSSGLANRIAAKNSRAINQMVRDMSAISRQEKRRIDLESQDEFQYLSDQINQMVERLQQLHDKTLDLETQKLLFEKRMLEAQFNPHFLYNTLETILITSHYDSALTEKIVIQLTKLLRYSLTDSSKPVLLKDDLSVIESYLVINQVRFEELQYSINLSPDLDSLAVPKLFLLPLIENAIKYGLKERHDVKINIACYYQDDHIIFSVRDNGSGIDAHHQKVIREQLEAGESHHGLINSYRRLKYHFSEVSLVFDQGDKQFNVSYHVKE
>NZ_CP011068.1|WP_002984836.1|788285_789074_+|response-regulator-transcription-factor
MYKLVIIEDEHIIRKWLRYAIDYKALDILVIGEAKDGKEGAVLIKESQPDIVLTDINMPIMTAFDMFEATKDQTYAKIILSGYADFPNARSAIHYGVLEFLTKPIEKAALWECLQTIIAKIEKQKGSNQKTDACVYIPLPQMTDQIPEVVKDILEWVHAHFQDKISTSRLAHDLGYSESYIYQNIKKHLQMPLSDYINQYRINQAIQLMQQEPDLMVYEIAQAVGIYDYRYFDRVFKKYLGQTVKAFKEEHFMKDTDRSKPC

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Crispr_ID: NZ_CP011068_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011068_3

1325610-1325772

TypeI

I-C

Consensus_repeat	Method
ATTTCAATCCACTCACCCATGAAGGGTGAGACT	PILER-CR

2 spacers

cas2,cas1,cas4,cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_CP011068_3

>merge|NZ_CP011068|3|1325610-1325772|PILER-CR
TTTCAATCCACTCACCCATGAAGGGTGAGACCACTCTTACTTTGAGAGTAAAGAAGCTCATGAAATTTCAATCCACTCACCCATGAAGGGTGAGACTATGTGGGTGTATTGGCTAGTCATGTAATTATTTATTTCAATCCACTCACCCATGAAGGGTGAGACT

>NZ_CP011068|3|2|1325610-1325772|PILER-CR
TTTCAATCCACTCACCCATGAAGGGTGAGACCA	CTCTTACTTTGAGAGTAAAGAAGCTCATGAAA
TTTCAATCCACTCACCCATGAAGGGTGAGACTA	TGTGGGTGTATTGGCTAGTCATGTAATTATTTA
TTTCAATCCACTCACCCATGAAGGGTGAGACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011068.1\|WP_002986896.1\|1321688_1322843_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP011068.1\|WP_002986891.1\|1319297_1319489_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_011284981.1\|1324102_1324726_-\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NZ_CP011068.1\|WP_011284982.1\|1324738_1325449_-\|thiol-disulfide-oxidoreductase-associated-membrane-protein-CcdA2	unknown	unknown	gnl\|CDD\|223856
NZ_CP011068.1\|WP_010922512.1\|1330669_1331398_-\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|273847
NZ_CP011068.1\|WP_011284983.1\|1326223_1327249_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NZ_CP011068.1\|WP_002989028.1\|1331530_1333939_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_CP011068.1\|WP_011054767.1\|1318558_1319287_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|226091
NZ_CP011068.1\|WP_015057910.1\|1327921_1328770_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|226175
NZ_CP011068.1\|WP_002986895.1\|1321048_1321570_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_002989018.1\|1337907_1338303_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|181104
NZ_CP011068.1\|WP_021341207.1\|1336742_1337306_-\|ATPase-AAA	unknown	unknown	unknown
NZ_CP011068.1\|WP_011284987.1\|1334092_1336741_-\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235582
NZ_CP011068.1\|WP_011284986.1\|1328774_1330670_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	gnl\|CDD\|273839
NZ_CP011068.1\|WP_002986887.1\|1318179_1318380_+\|KTSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|379296
NZ_CP011068.1\|WP_002989044.1\|1325919_1326213_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|224262
NZ_CP011068.1\|WP_002983779.1\|1322953_1324060_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|184456
NZ_CP011068.1\|WP_011284984.1\|1327245_1327920_-\|CRISPR-associated-protein-Cas4	cas4	COG1468_cas4_CAS-I-A:CAS-I-B:CAS-I-C:CAS-I-D:CAS-II-B	gnl\|CDD\|224385
NZ_CP011068.1\|WP_011054768.1\|1320284_1320644_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP011068.1\|WP_002986894.1\|1320657_1321038_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368753

Protein	Function_ID	Function_description	E-value
NZ_CP011068.1\|WP_002986896.1\|1321688_1322843_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.16705e-43
NZ_CP011068.1\|WP_002989028.1\|1331530_1333939_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	2.76387e-159
NZ_CP011068.1\|WP_011284981.1\|1324102_1324726_-\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	2.08316e-34
NZ_CP011068.1\|WP_011284982.1\|1324738_1325449_-\|thiol-disulfide-oxidoreductase-associated-membrane-protein-CcdA2	gnl\|CDD\|223856	COG0785, CcdA, Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones].	2.85986e-42
NZ_CP011068.1\|WP_010922512.1\|1330669_1331398_-\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|273847	TIGR01876, cas_Cas5d, CRISPR-associated protein Cas5, subtype I-C/DVULG. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum. This family belongs to a set of several Cas protein families, one each for a number of different CRISPR/Cas subtypes, that share a region of N-terminal sequence similarity modeled by TIGR02593. This family represents the Dvulg subtype of CRISPR/Cas locus.	3.32713e-117
NZ_CP011068.1\|WP_011284983.1\|1326223_1327249_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NZ_CP011068.1\|WP_011054767.1\|1318558_1319287_-\|oxidoreductase	gnl\|CDD\|226091	COG3561, COG3561, Phage anti-repressor protein [Transcription].	2.15147e-42
NZ_CP011068.1\|WP_015057910.1\|1327921_1328770_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|226175	COG3649, COG3649, CRISPR system related protein [Defense mechanisms].	2.68212e-160
NZ_CP011068.1\|WP_002989018.1\|1337907_1338303_-\|hypothetical-protein	gnl\|CDD\|181104	PRK07758, PRK07758, hypothetical protein; Provisional.	0.000151325
NZ_CP011068.1\|WP_011284987.1\|1334092_1336741_-\|valine--tRNA-ligase	gnl\|CDD\|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0
NZ_CP011068.1\|WP_011284986.1\|1328774_1330670_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|273839	TIGR01863, CRISPR-associated_protein_CT1133_family, CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein that tends to be found near CRISPR repeats of the DVULG subtype of CRISPR/Cas locus. We designate this family Csd1 (CRISPR/Cas Subtype DVULG protein 1). The species range for this subtype, so far, is exclusively bacterial and mesophilic, although CRISPR loci in general are particularly common among archaea and thermophilic bacteria. In a few species (Xanthomonas axonopodis pv. citri str. 306 and Streptococcus mutans UA159), homology to this protein family is split across two tandem genes; the trusted cutoff to this family is set low enough to capture at least the longer of the two.	0
NZ_CP011068.1\|WP_002986887.1\|1318179_1318380_+\|KTSC-domain-containing-protein	gnl\|CDD\|379296	pfam13619, KTSC, KTSC domain. This short domain is named after Lysine tRNA synthetase C-terminal domain. It is found at the C-terminus of some Lysyl tRNA synthetases as well as a single domain in bacterial proteins. The domain is about 60 amino acids in length and contains a reasonably conserved YXY motif in the centre of the sequence. The function of this domain is unknown but it could be an RNA binding domain.	5.60317e-09
NZ_CP011068.1\|WP_002989044.1\|1325919_1326213_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|224262	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms].	1.60225e-34
NZ_CP011068.1\|WP_002983779.1\|1322953_1324060_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|184456	PRK14018, PRK14018, bifunctional peptide-methionine (S)-S-oxide reductase MsrA/peptide-methionine (R)-S-oxide reductase MsrB.	3.04644e-163
NZ_CP011068.1\|WP_011284984.1\|1327245_1327920_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|224385	COG1468, COG1468, CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms].	3.0744e-43
NZ_CP011068.1\|WP_011054768.1\|1320284_1320644_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	8.27575e-08
NZ_CP011068.1\|WP_002986894.1\|1320657_1321038_+\|hypothetical-protein	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	0.00284034

>NZ_CP011068.1|WP_011284982.1|1324738_1325449_-|thiol-disulfide-oxidoreductase-associated-membrane-protein-CcdA2
MTLSLVLMVSVFGAGLLSFFSPCIFPVLPVYLGILLDADDSKTITIFGKKLYWYGIVKTLAFIFGLSTIFVILGYGAGFLGNILYAVWFRYLLGALVIILGIHQMGLITIKSLQFQKSLTFHNNKNRNGLFNAFILGLTFSFGWTPCVGPVLSSVLALVASGGNGAWQGGVLMIIYTLGLGIPFLLISFASGIVLKQFNKLKPHIFLLKKVGGVLIIVMGILLMTGTLNNLAQLFG
>NZ_CP011068.1|WP_011284981.1|1324102_1324726_-|TlpA-family-protein-disulfide-reductase
MKKGLLVTTGLACLGLLTACSTQDNMVKKEITQDKMSMAVKKKDKMSTSKDKSMMADKSSDKKMTNDGPMAPDFELKGIDGKTYRLSEFKGKKVYLKFWASWCSICLSTLADTEDLAKMSDKDYVVLTVVSPGHQGEKSEADFTKWFQGTDYKDLPVLLDPDGKLLEAYGVRSYPTEVFIGSDGVLAKKHIGYAKKSDIKKTLKGIH
>NZ_CP011068.1|WP_002983779.1|1322953_1324060_-|peptide-methionine-(R)-S-oxide-reductase-MsrB
MEHKWKLWLFIVGVVLLIGGASVLIQKGQAKAFSQGKPQLPAKKVKSTKVDPNAPVDQKVIYLAGGCFWGVEEYFSQVDGVLDAVSGYANGRGDTTNYQLIHQTGHAETVEVTYDANRISLKELLLHFFRIIDPTSLNKQGNDRGSQYRTGIYYTDKADLAIIDEVFKEKAKDYKKKIVVEKAPLKHFIKAEDYHQDYLKKNPNGYCHIDINQATYPVIDESKYPKPSATEIKAKLSADEYRVTQKNETEKAFSNRYWDSFDAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPDVVRYKEDKSFNMTRTEVRSRSGNSHLGHVFTDGPKDQGGLRYCINSLSITFIPKADMEAKGYGYLLSSVE
>NZ_CP011068.1|WP_002986896.1|1321688_1322843_+|site-specific-integrase
MPISYLKISTPQRKERGKTMIEKYTKKDGTTAYRLRAYLGVDPVTGKQVRTTRQGFKTEREAKRAEVKLIDDFQRQGAWKSNDKTTFDDVAKLWFEQYQNTVKPSTFLVNQNYYKTILKPHLGQLQMTKITVMICQKFVNCLSRYSGYTLYLSLANRIFKFAVNLGIIDNNPMNKTLRSKCTYKNVDTLTKKYYTKEELNTFLRLVEAEETLEMRLIYRLLSYGGFRIGELIALKDTDFDFRNNTISITKTIAYTKEGWAVQSPKTKKSNRTISMDAETMSLAKLYIKQSIKPLHGSFKLFNFASDTVRKRLDRFILKHGLKRITPHGFRHTHASLLFEAGIPAKIAQERLGHAKIAITMDLYTHLSKKSKDNVADKLAELVAI
>NZ_CP011068.1|WP_002986895.1|1321048_1321570_+|hypothetical-protein
MKKIVYLFTLSVLIVCLGACTGGSKKDTTSKTPSSDTSKVSGDMSEKEYFDTLISKIDKVTTDNYKSDEYLFYDYKTILRDPKKYFSLKVRINNLKIIQISDKDKYTKMLANTPNGDLYMLFIETKRLETKLLETDNITINGRYLLSYEYTTTSGSENSVPLIYIDGYLLLDK
>NZ_CP011068.1|WP_002986894.1|1320657_1321038_+|hypothetical-protein
MMTPETVCQEKGIDLVYFDGRGTNIPGMFNKKHNVIAIDTYLDGIYKHKVIYHELGHREHTASYYKLNKEKAELQADRCMIHHLLKEELSYWDNMEDFNYIQFMEKYELTSIADEVMVKEEFKNLI
>NZ_CP011068.1|WP_011054768.1|1320284_1320644_+|helix-turn-helix-transcriptional-regulator
MTMFEVYSRIEALAKKRGVSLQKVATDIGLSENYIYNLKSKKTANTDPIEKIANYFNVSTDYLLGRTDNPKMAQDGHTSVAIDLKKDAEETFFFDGHELNDEDIDLITSILETRIKNRK
>NZ_CP011068.1|WP_002986891.1|1319297_1319489_-|hypothetical-protein
MPDNAIAIEKIKKYLLDNNLKQVDLAVTYGKEPQDVANILAGRKKDPASNRFVLKVISDLKIR
>NZ_CP011068.1|WP_011054767.1|1318558_1319287_-|oxidoreductase
MNNLITVTLNENQEPIVSGRDLHQALEIKTQYTKWLERMSDYGFEENEDYVAISQKRLTAQGNQTEYTDHVLKLDMAKEIAMLQRNEKSKQVRKYFIQIEKDFNSPEKIMARALLMADKKVHKLEAQIEADRPKVLFADAVSASKSSCLIGELAKILKQNGVNIGQNKLFQWLRANGYLISRRGESWNQPTQKSMQLGLFELKKTAINHSDGHTTTNVTPKVTGKGQQYFINKFFNQEYLPV
>NZ_CP011068.1|WP_002986887.1|1318179_1318380_+|KTSC-domain-containing-protein
MQRQYVSSSNARSVDWENNTLEVEFNNGSIYHYHNVSQTEYRSVLVGSVGSNIHRLAKIHTYTRIV
>NZ_CP011068.1|WP_002989044.1|1325919_1326213_-|CRISPR-associated-endonuclease-Cas2
MMVLVTYDVNTETPAGRKRLRHVAKLCVDYGQRVQNSVFECSVTPAEFVDIKHRLTQIIDEKTDSIRFYLLGKNWQRRVETLGRSDSYDPDKGVLLL
>NZ_CP011068.1|WP_011284983.1|1326223_1327249_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MKKLLNTLYLTQEDFYVTKEGDNIVIKQEGKVLKRFPFRIIDGIVCFSYLGVSPALVKLCTENQINLSFHTPQGRFCGRYIGSTNGNVLLRREHYRLSDREESLEYAKRFILAKISNSRKYLLRFKRDHRQQIDTKLFEAVNDELIWALEMVQAADNKDSLRGIEGQAANQYFRIFNDLVLTDKKTFYFQGRSKRPPLDCVNALLSFGYSLLTFECQSALEAVGLDSYVGFFHTDRPGCASLALDLVEEFRSYIVDRFVFSLINKGQLQKKHFEVKENGSILMTENGRAIFIDLWQKRKHTEVEHPFTKEKVKLMLLPYVQAQLLAKAIRGDLESYPPFMV
>NZ_CP011068.1|WP_011284984.1|1327245_1327920_-|CRISPR-associated-protein-Cas4
MVYAEDDYLMLSGIQHFQFCKRQWALIHIEQQWLDNEATAHGQVLHTKADNPYIKEKRKELLVSRAMPISSAELGLSGIMDVVEFYKDDQGVSLRGKRGKWLPKVVEYKRGKPKKDTRDIVQLVAQTMCLEETLDCDINEGCLYYHSVNQRVIVPMTSALRQEVKELAAEMQEVYQSQMLPKAAYFKNCQLCSLVDICKPRLSKKTRSVSRYINEAMTSEEMDL
>NZ_CP011068.1|WP_015057910.1|1327921_1328770_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MLEHKIDFMVTLEVKEANANGDPLNGNMPRTDAKGYGVMSDVSIKRKIRNRLQDMGKSIFVQANERIEDDFRSLERRFSQHFTAKTPDKEIEEKANALWFDVRAFGQVFTYLKKSIGVRGPVSISMAKSLEPIVISSLQITRSTNGMEAKNNSGRSSDTMGTKHFVDYGVYVLKGSINAYFAEKTGFSQEDAEAIKEVLVSLFENDASSARPEGSMRVCEVFWFTHSSKLGNVSSARVFDLLEYHQSIEEKSTYDAYQIHLNQEKLAKYEAKGLTVEILEGL
>NZ_CP011068.1|WP_011284986.1|1328774_1330670_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MDFFTSLLKTYEKAELADLVDHQKRSNEPVLLPIYHTSLKSNGKNIISVKLDKDGQFHKAEFMADKQMIIFPVTADSVARSGSHPAPHPLVDKFAYYSAEMGQSQYDSFHKQLNNWIDYCEEGDVKRFLTIVQQFILKPEFLTLILDSLIGPDYQNNQLKVTFCDATGKEKLIDLSACFLEFSIDQFQGFKNESVSTFKTLHQSYISFVEANREKLGICNISGREEQLTDKHRGLMGNAKIISVSNKREAYKGRFREREDVFSVGYETSEKIHLMLKYLLENKNTSTWLGSSQYLINWFSDDLTNDSRLDIVSPIFDDGLEEDDDDDTPPVITLATEDNKRIGKSFIKGQKLFANDATYYVAILNKTSNGRIALKYFRQLQASQLLTNLNKWQETYSWESRSKFGKSRLRTPTFHDILNVSYGVDRDRFLELDNDNFKSDQIQKLVASLIDGKPMPQSIVKKLGNNVKERHRYRKHWYQVEQVCLAILHKQNGEEFSPMLDHTNQNRSYLFGRLLAIFELIETLRYGLDGNNNDRITNAERYWTAYTGQPTKLMMLLENKIKPYEEPLKLNRRGSWMKLEKEKEEILELLNPLLETETMEKPLDYRFIFGYYAEKNYYYTKQNTEVTESEE
>NZ_CP011068.1|WP_010922512.1|1330669_1331398_-|type-I-C-CRISPR-associated-protein-Cas5
MYRSRDFYVRVSGQRALFTNPATKGGSERSSYSVPTRQALNGIVDAIYYKPTFTNIVTEVKVINQIQTELQGVRALLHDYSADLSYVSYLSDVVYLIKFHFVWNEDRKDLNSDRLPAKHEAIMERSIRKGGRRDVFLGTRECLGLVDDISQEEYETTVSYYNGVNIDLGIMFHSFAYPKDKKTPLKSYFTKTVMKNGVITFKAQSECDIVNTLSSYAFKAPEEIKSVNDECMEYDAMEKGEN
>NZ_CP011068.1|WP_002989028.1|1331530_1333939_-|CRISPR-associated-helicase/endonuclease-Cas3
MRMILAHYDCKKDKKQSLDEHLWHVACSSRQEASIIGQGDVLFLIGLYHDLGKADRTFQDKLLNNPNRHVDHSYAGAKYLCSIIGPHLKNRGVDKNERMTFNEMVGYVISAHHGMYDLCYYFDDAEYYGFNKFKNRINRDLDGYHYHEDIKGYALKLEKKLCDYGYKDLRELIDKAFDNYQQAMSSLNWQDKSEWDYYQSCMVRLYLSLLKNADILDTVNAYGLKISPMDKTERSFLKHSYLAAIEQKYASFGQPNNQLNTIRTEIAERVKERGKRDSKGIYRLDLPTGAGKTNLSMRYAFHQLVHHDKSRFFYITPFLSVLEQNASEIRKVTGDLGVLEHHSNVVKQANEDDDDKDSLLSAYLSDSWDSQVVLTSMVQFFQTLFKTKSANLRRFSSLINSVVILDEVQSLPIEVTTLFNLTMNFLNKVMDTTIVLCTATQPAYDSSEIDHRICYGGNLGELAEIVELTIEEKQIFSRTELRKFDDSDQKVHLTDVINLILGEENSVLAIFNTKKTVHNCYTMLKDITDRPVYQLSTNMCAQHRLDLIAKIKTELQNNIPIICISTQLIEAGVDVDFHRVIRSYSGIDSIVQAAGRCNREGKRDKGQVTLVNLTNEEENISRLTEIKAKKEATESILHKIGSPIDISTLNRDFFEYYYANNQGLMDYPLEDNLSIYDYLSLNIYQTANKKFKGKLKQAFKTAGAKMNLINNDMIGILVPYGEAEKKLAYLEELGMSHFLSAEDYQTIKSLLKELQPFTVNVRENDPLFETTKSYLNGQILVLTSEYYDTERGVKYDSASFYF
>NZ_CP011068.1|WP_011284987.1|1334092_1336741_-|valine--tRNA-ligase
MTELSPKYNPAEVEAGRYQKWLDADVFKPSGDQKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEERLREQGISRYDLGRDKFLDKVWEWKDEYATTIKEQWGKMGLSVDYSRERFTLDEGLSKAVRKVFVDLYKKGWIYRGEFIINWDPAARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALQVATTRPETMFGDVAVAVNPEDPRYKDLIGKNVILPIVNKLIPIVGDEHADPEFGTGVVKITPAHDPNDFEVGQRHNLPQVNVMNDDGTMNELAGDFAGMDRFEARQATVAKLEELGALVNIEKRVHSVGHSERSGAVVEPRLSTQWFVKMDELAKQAMDNQETDNRVDFYPPRFNDTFLQWMENVHDWVISRQLWWGHQIPAWYNAEGEIYVGEEAPEGDGWTQDEDVLDTWFSSALWPFSTMGWPDTDVEDFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGRQPFQNVLIHGLIRDEEGRKMSKSLGNGIDPMDVIEKYGADSLRWFLSNGSAPGQDVRFSYEKMDASWNFINKIWNISRYILMNNEGLTLEEAESNVAKVAASEAGNVTDQWILHNLNETIAKVTENFDKFEFGVAGHILYNFIWEEFANWYVELTKEVLYSDNEAEKVITRSVLLYTLDKIVRLLHPIMPFVTEEIYAQYAQGSIVTVDYPVVRPAFENEAAHKGVERLKDLIRAVRNARAEVNVAPSKPITILVKTADSELEDFFTSNVNYIKRFTNPEKLEISSAIAAPELAMTSIITGAEIYLPLADLLNVEEELARLDKELAKWQKELDMVGKKLGNERFVANAKPEVIQKEKDKQADYQAKYDATQERIAEMKKIKS
>NZ_CP011068.1|WP_021341207.1|1336742_1337306_-|ATPase-AAA
MNLIIIGAQASGKMTIEQEVARQTGMNLFHNHDSIDFVLRFMPWSQESTALIERMRFAFFETFAKTGQDMIFTIVIDFNDPNDVAMLEKIQAVFQSYDQEVLFVELKTDIEERLKRNRTENRLKHKPLKRNIEWSEQDIQSTMAYAVFNPEEPPKTLTHYQKINNTHLTAAETAQLIIQKMTHIKEN
>NZ_CP011068.1|WP_002989018.1|1337907_1338303_-|hypothetical-protein
MAKQKNRKKALKLEMKRNGLLKKAGQVFDKAVESVETAVDKTISAGKNLVEKGSQTVENLTASKERLTLDEFAGQPVVAGIRSDLVETLYAEGIHSAQAFKEWTEKDLLALKGIGPATVKKLVENGASFKK

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Crispr_ID: NZ_CP011068_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011068_4

1908408-1908504

Orphan

Consensus_repeat	Method
AAAAACCCAATTTTTTTTCGTCTTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011068_4

>merge|NZ_CP011068|4|1908408-1908504|CRISPRCasFinder
AAAAACCCAATTTTTTTTCGTCTTATTTTTGCAAAATCTATATTAACGCAAATAAATTTGGTTGTCAAGATAAAAATCCAATTTTTTTTCGTCTTAT

>NZ_CP011068|4|3|1908408-1908504|CRISPRCasFinder
AAAAACCCAATTTTTTTTCGTCTTAT	TTTTGCAAAATCTATATTAACGCAAATAAATTTGGTTGTCAAGAT
AAAAATCCAATTTTTTTTCGTCTTAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011068.1\|WP_021340724.1\|1913979_1915956_-\|DHH-family-phosphoesterase	unknown	unknown	gnl\|CDD\|226404
NZ_CP011068.1\|WP_011285314.1\|1905576_1906098_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_011285324.1\|1913530_1913983_-\|50S-ribosomal-protein-L9	unknown	unknown	gnl\|CDD\|234659
NZ_CP011068.1\|WP_011285322.1\|1908560_1909004_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP011068.1\|WP_011285327.1\|1918067_1918385_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240044
NZ_CP011068.1\|WP_047716045.1\|1916045_1917944_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	unknown	unknown	gnl\|CDD\|235362
NZ_CP011068.1\|WP_002982092.1\|1910503_1911115_-\|30S-ribosomal-protein-S4	unknown	unknown	gnl\|CDD\|235411
NZ_CP011068.1\|WP_011285321.1\|1908203_1908392_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP011068.1\|WP_021340719.1\|1919160_1920282_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NZ_CP011068.1\|WP_002991405.1\|1911844_1912117_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226872
NZ_CP011068.1\|WP_002991408.1\|1912133_1913495_-\|replicative-DNA-helicase	unknown	unknown	gnl\|CDD\|180232
NZ_CP011068.1\|WP_000694580.1\|1903513_1903687_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_011285320.1\|1907621_1908188_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226144
NZ_CP011068.1\|WP_014407970.1\|1907322_1907565_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_011285315.1\|1906107_1906476_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_021340713.1\|1906384_1906576_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_011285323.1\|1909183_1910347_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP011068.1\|WP_011285313.1\|1903973_1905587_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_011285318.1\|1906919_1907102_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011068.1\|WP_011285317.1\|1906575_1906908_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011068.1\|WP_021340724.1\|1913979_1915956_-\|DHH-family-phosphoesterase	gnl\|CDD\|226404	COG3887, COG3887, Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms].	0
NZ_CP011068.1\|WP_011285324.1\|1913530_1913983_-\|50S-ribosomal-protein-L9	gnl\|CDD\|234659	PRK00137, rplI, 50S ribosomal protein L9; Reviewed.	1.02239e-55
NZ_CP011068.1\|WP_011285322.1\|1908560_1909004_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	8.81587e-06
NZ_CP011068.1\|WP_047716045.1\|1916045_1917944_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	gnl\|CDD\|235362	PRK05192, PRK05192, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG.	0
NZ_CP011068.1\|WP_011285321.1\|1908203_1908392_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	0.00222954
NZ_CP011068.1\|WP_021340719.1\|1919160_1920282_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP011068.1\|WP_002991405.1\|1911844_1912117_-\|hypothetical-protein	gnl\|CDD\|226872	COG4466, Veg, Uncharacterized protein conserved in bacteria [Function unknown].	7.52485e-33
NZ_CP011068.1\|WP_002991408.1\|1912133_1913495_-\|replicative-DNA-helicase	gnl\|CDD\|180232	PRK05748, PRK05748, replicative DNA helicase; Provisional.	0
NZ_CP011068.1\|WP_011285320.1\|1907621_1908188_-\|hypothetical-protein	gnl\|CDD\|226144	COG3617, COG3617, Prophage antirepressor [Transcription].	1.58213e-27
NZ_CP011068.1\|WP_011285323.1\|1909183_1910347_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.50808e-45
NZ_CP011068.1\|WP_011285327.1\|1918067_1918385_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240044	cd04688, Nudix_Hydrolase_29, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	7.82374e-17
NZ_CP011068.1\|WP_002982092.1\|1910503_1911115_-\|30S-ribosomal-protein-S4	gnl\|CDD\|235411	PRK05327, rpsD, 30S ribosomal protein S4; Validated.	8.00838e-118

>NZ_CP011068.1|WP_011285321.1|1908203_1908392_-|helix-turn-helix-transcriptional-regulator
MLITENIAVKVRKKRAVKQLGKVELSKKLGITPPTLSKIEAGNYKAPKRIYASVMEWLAEDY
>NZ_CP011068.1|WP_011285320.1|1907621_1908188_-|hypothetical-protein
MNRQVSIFEEVNDQGGAFQVVTTMTFHDRLLDIYGNIQEPLFRARDVAEMIDHSKTRNGYYDVQSMLRKVDDDEKVKGVPLEGATKNFRSGQKVWFLTEHGLYEVLMRSSKPKAKEFRKAVKNILKEIRLNGYYMQGELVQNSQPTPDIDDLSYIKQKLTDLQDVDSLQDLRWKMAKLYHVIETLDEY
>NZ_CP011068.1|WP_014407970.1|1907322_1907565_-|hypothetical-protein
MKATTYKELKKWIDEGVDLAELAQGYADKVPSVDREQFEAVTQGIFNVLEGVSLMLDDKVLIYNRKAEQKRLNDIEQGDY
>NZ_CP011068.1|WP_011285318.1|1906919_1907102_-|hypothetical-protein
MTSVRTAQLLNNGLGLVGQDLKDVLSALANSVNPSIEKQISHIMIDRANTGEWLANVGKK
>NZ_CP011068.1|WP_011285317.1|1906575_1906908_-|hypothetical-protein
MKYRVETNPFSKDRYTPEQLEMFKNRQLSKNKAEAYFTRLYNQHIAWVIIANVMTEYVNKFRKSATSFEKAWDALGYQQTTEIVFRAVNGLPCSEKDTGELETYLSEVSA
>NZ_CP011068.1|WP_021340713.1|1906384_1906576_-|hypothetical-protein
MQELNLTPTQTLILFIVLGLVGLLLSLSKPLIEIDLPEDTQVPKPPQNANYGAYIQSQNHYYN
>NZ_CP011068.1|WP_011285315.1|1906107_1906476_-|hypothetical-protein
MTYQKIPKYLNHLRTQTMGLIFNHRTIITIRREQMQLLSREAELELLEKVGCYLEKRWQLELENKDDWDLIPRQDLLEKLDITGTTLKNWEKEGLKSYQSPFENSKKVYYRKSDIYNFLSVD
>NZ_CP011068.1|WP_011285314.1|1905576_1906098_-|hypothetical-protein
MDYLEVTMTKDCVKIFNFLYKYPTKAYQKDEYFKLLYMHPLDSFLTSFSLSGIRVKVTDKPVLAGWKLVRDIEVRIATGELLEMIEELEICYLRKHQTVSYVEIKFYVVHLLTYGIRSRYDMQFFTKLLFCCGYDQETVIGIYSNITKNTRLSRDFITLQAKLYQTKKGTHEH
>NZ_CP011068.1|WP_011285313.1|1903973_1905587_-|hypothetical-protein
MSIKENIDKLVSMEWTESIFGQSKMKADYKRQLSKVIELDTLSNIHHNGETYAVSNQEVMYLSESKGRTHKFISGNVKTKSKGKGRDSQKYLVVSFDHQFPPFAKLVVDYLLGRFTFFNNKLYDVNNRQAQVLDDFTIQSLYGFKKDNPFILEILEGIHQTLNIRPAKQLEAYKISGRDFIIDLKEHRLYRTNPSSDSSFFKFYDVDYHTAIGSKKKVGKFLDYVIADHDSLHNATLQAYYIAQVACGLKSKQNFFISKSGVRTGKGLRHIGLSGIFNKIDVELDLLIKGGFEASNAWGAFAGGEMALATEQGDIVGDKMERVLKIIATEKTHMARSIGGNLGTVNLTSVLCIDTNRTVALSDEMNGRAVLIQYQNRPEGETDLEREKAFEEYWQTFTEMDKSPKIEGVIGFLLVSLDYFRKNDMKFDWRAVEVVNDDDLDDFQVYLINHLSEKDFVERDSYVRELYNSTYGKNNNQAGQRMRTIGVKSYRKQTTGGRKIPGYKVDNIKRFNKFSGGEKENTNIFDMFEKLNQPLPP
>NZ_CP011068.1|WP_000694580.1|1903513_1903687_-|hypothetical-protein
MKIKLFYQKHNESLDDFEYRVNQFTLSVSVIDIKLSEATYGNYEDMSTTTSLLVLYR
>NZ_CP011068.1|WP_011285322.1|1908560_1909004_+|helix-turn-helix-transcriptional-regulator
MENRLQKIRKEQTNLNQKDFFDQVVNKKLNLDISFRTYQNWENPKNTIKPDKAQILADYFGVWLPYLLGNSNIRTEEQANFLAEMNKRINSEGDSFSFDMTATESDEHDLLYNYRQLETPYKNQVRKFTRDMWELQKESKNFSPKSP
>NZ_CP011068.1|WP_011285323.1|1909183_1910347_+|site-specific-integrase
MNIKEYKKKNGTIIYRTSVYLGVDQVTGKKARTTITASTKKGVKIKARDALNNFAMNGYTVKEKPTVTTYKELTALWWESYKNTIKPNSRQSMEGIVRLHILPAFGDCKLSKLTTPVIQQQVNKWANNANKGIKGAYANYSFLNNINRRILQYGVTMQVIEHNPARDVIIPRKQNNKEHKVKFFSNQELKQFLNYLDDLDLSSYENFFDYVLYKTLLATGCRIGEVLALEWSDIDLKKGTIKVSKTLNRYQETNTPKSKAGLRDIEIDRATVLLLKQYKNRQQVLSWDLGRSETIVFTPFTTKYAYACLLRKRLQKHFKAAGVPDISFHGFRHTHATIMLYAGIEAKDLQYRLGHSNISMTLNTYVHATKEGAKKAVSIFETAISNL
>NZ_CP011068.1|WP_002982092.1|1910503_1911115_-|30S-ribosomal-protein-S4
MSRYTGPSWKQSRRLGLSLTGTGKELARRNYVPGQHGPNNRSKLSEYGLQLAEKQKLRFSYGLGEKQFRNLFVQATKIKEGTLGFNFMVLLERRLDNVVYRLGLATTRRQARQFVNHGHILVDGKRVDIPSYRVDPGQVISVREKSMKVPAILEAVEATLGRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML
>NZ_CP011068.1|WP_002991405.1|1911844_1912117_-|hypothetical-protein
MSDAFTDVAKMKKIKEDIRAHEGQLVELTLENGRKREKNKIGRLIEVYSSLFIIEYSDSSDTPGAIDNSYVESYTYSDILTEKTLIRYLD
>NZ_CP011068.1|WP_002991408.1|1912133_1913495_-|replicative-DNA-helicase
MPEVAELRVQPQDLLAEQSVLGSIFISPDKLIAVREFISPDDFYKYAHKIIFRAMITLSDRNDAIDATTIRTILDDQDDLQSIGGLSYIVELVNSVPTSANAEYYAKIVAEKAMLRDIIARLTESVNLAYDEILKPEEVIAGVERALIELNEHSNRSGFRKISDVLKVNYEALEARSKQTSNVTGLPTGFRDLDKITTGLHPDQLVILAARPAVGKTAFVLNIAQNVGTKQKKTVAIFSLEMGAESLVDRMLAAEGMVDSHSLRTGQLTDQDWNNVTIAQGALAEAPIYIDDTPGIKITEIRARSRKLSQEVDGGLGLIVIDYLQLITGTKPENRQQEVSDISRQLKILAKELKVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYRDDYYRKEGDDAEEAVEDNTIEVILEKNRAGARGTVKLMFQKEYNKFSSIAQFEER
>NZ_CP011068.1|WP_011285324.1|1913530_1913983_-|50S-ribosomal-protein-L9
MKVIFLADVKGKGKKGEIKEVPTGYAQNFLIKKNLAKEATSQSIGELKGKQKAEEKAQAEILAEAQAVKAVLDEDKTRVQFQEKVGPDGRTFGSITAKKISEELQKQFGVKVDKRHIVLDHPIRAIGLIEVPVKLHKEVTAEIKLTITEA
>NZ_CP011068.1|WP_021340724.1|1913979_1915956_-|DHH-family-phosphoesterase
MKKFRFETIHLIMMGLILFGLLALCVSIMQSKILILLAIFLVLLFVVALLWYQKEAYHLSDLAHIELLNEQTEDNLKTLLDNMPVGVVQFDQETNAVEWYNPYAELIFTTEEGFIQNSLIQQIITEKRREDISQTFEVSGNKYTSYIDVSSGIFYFFDSFVGNRQLADASMLRPVVGIISVDNYDDITDDLSDADTSKINSFVANFIDEFMESKRIFYRRVNMDRYYFFTDFKTLNDLMDNKFSVLEEFRKEAQDAQRPLTLSIGISFGEENHSQIGQVALENLNIALVRGGDQIVIRENADHTNPIYFGGGSVSTVKRSRTRTRAMMTAISDRIKMVDNVFIVGHRKLDMDALGSAVGMQFFAGNIIENSFAVYNPDEMSPDIERAIERLQADGKTRLISVSQAMGLVTPRSLLVMVDHSKISLTLSKEFYEQFQNVIVVDHHRRDDDFPDNAILTFIESGASSAAELVTELIQFQNAKKRLNKIQASVLMAGIMLDTKNFSTRVTSRTFDVASYLRSKGSDSVEIQNISATDFEEYKQINEIILQGERLGDSIIVAAGEKNHLYSNVIASKAADTILSMAHVEASFVLVETASHKIAISARSRSKINVQRVMEKLGGGGHFNLAACQLTDISLPQAKHLLLKTINMTMKETGEVES
>NZ_CP011068.1|WP_047716045.1|1916045_1917944_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG
MTHEFTESYDVIVIGAGHAGVEASLATSRMGCKTLLATINLDMLAFMPCNPSIGGSAKGIVVREIDALGGEMGKNIDKTYIQMKMLNTGKGPAVRALRAQADKSLYAREMKHTVEKQANLTLRQTMIDDILVEDGRVVGVLTATGQKFAAKAVVVTTGTALRGEIILGELKYSSGPNNSLASVTLADNLKKLGLEIGRFKTGTPPRVKASSINYDQTEIQPGDDKPNHFSFMSKDAEYLKDQIPCWLTYTNQTSHDIINQNLYRAPMFSGIVKGVGPRYCPSIEDKIVRFADKERHQLFLEPEGRDTEEVYVQGLSTSLPEDVQKDLIHSIKGLEKAEMMRTGYAIEYDIVLPHQLRATLETKLISGLFTAGQTNGTSGYEEAAGQGLIAGINAALKVQGKPELILKRSDAYIGVMIDDLVTKGTLEPYRLLTSRAEYRLILRHDNADMRLTEIGRDIGLVDDERWKAFEIKKNQFDNELKRLNSIKLKPVKSTNDRVQELGFKPLTDAMTAKEFMRRPEIDYATAVSFVGPAAEDLDAKIIELLETEIKYEGYIRKALDQVAKMKRMEEKRIPANIDWDAIDSIATEARQKFKKINPETIGQASRISGVNPADISILMIYLEGNGKAHRKY
>NZ_CP011068.1|WP_011285327.1|1918067_1918385_-|NUDIX-domain-containing-protein
MIVRNGKNFLTRDAADQYYTIGGTSLVGEKTHETVLRETLEEVGIRTKVNQLAFVVENHFDIDDVFWHNIEFHYLVSPLEDPKLEMIENASDRFVNGFQSINWIK
>NZ_CP011068.1|WP_021340719.1|1919160_1920282_-|tRNA-2-thiouridine(34)-synthase-MnmA
MTDNSKIRVVVGMSGGVDSSVTALLLKEQGYDVIGVFMKNWDDTDEFGVCTATEDYKDVAAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYAQVKRDENGTVHMLRGADNGKDQTYFLSQLSQEQLQKTLFPLGHLQKSEVREIAERAGLATAKKKDSTGICFIGEKNFKQFLSQYLPAQKGRMMTIDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNQPWFVVGKDLSQNILYVGQGFYHEALMSNSLDASVIHFTREMPEEFTFECTAKFRYRQPDSHVAVHVRGDKAEVVFAEPQRAITPGQAVVFYDGKECLGGGMIDMAYKNGQPCQYI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP011068_2	2.1\|776997\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	776997-777026	30	MK448662	Streptococcus satellite phage Javan97, complete genome	6081-6110	0	1.0
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	MK448775	Streptococcus phage Javan489, complete genome	25298-25327	0	1.0
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	MK448794	Streptococcus phage Javan525, complete genome	22421-22450	0	1.0
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	MK448953	Streptococcus phage Javan474, complete genome	27019-27048	0	1.0
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	MK448765	Streptococcus phage Javan459, complete genome	22420-22449	0	1.0
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	MK448957	Streptococcus phage Javan484, complete genome	27899-27928	0	1.0
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448871	Streptococcus phage Javan196, complete genome	33084-33113	0	1.0
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448697	Streptococcus phage Javan185, complete genome	33084-33113	0	1.0
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448693	Streptococcus phage Javan177, complete genome	33084-33113	0	1.0
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448772	Streptococcus phage Javan483, complete genome	32792-32821	0	1.0
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448696	Streptococcus phage Javan183, complete genome	33084-33113	0	1.0
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	NC_009819	Streptococcus phage P9, complete genome	32033-32062	0	1.0
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448793	Streptococcus phage Javan523, complete genome	33428-33457	0	1.0
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448868	Streptococcus phage Javan188, complete genome	33085-33114	0	1.0
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448866	Streptococcus phage Javan184, complete genome	33084-33113	0	1.0
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448954	Streptococcus phage Javan476, complete genome	31815-31844	0	1.0
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448699	Streptococcus phage Javan189, complete genome	33084-33113	0	1.0
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448867	Streptococcus phage Javan186, complete genome	33084-33113	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448767	Streptococcus phage Javan467, complete genome	17890-17919	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448685	Streptococcus phage Javan155, complete genome	18198-18227	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448771	Streptococcus phage Javan481, complete genome	17415-17444	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448829	Streptococcus phage Javan7, complete genome	19776-19805	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448736	Streptococcus phage Javan35, complete genome	20259-20288	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448781	Streptococcus phage Javan5, complete genome	22281-22310	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK449012	Streptococcus phage Javan94, complete genome	19127-19156	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	NC_004586	Streptococcus pyogenes phage 315.3, complete genome	17995-18024	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448969	Streptococcus phage Javan514, complete genome	19138-19167	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MH853355	Streptococcus phage LF1, complete genome	10633-10662	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448964	Streptococcus phage Javan502, complete genome	17719-17748	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448943	Streptococcus phage Javan450, complete genome	17890-17919	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448972	Streptococcus phage Javan520, complete genome	17264-17293	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448938	Streptococcus phage Javan44, complete genome	20260-20289	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448855	Streptococcus phage Javan150, complete genome	18394-18423	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448786	Streptococcus phage Javan509, complete genome	17890-17919	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448774	Streptococcus phage Javan487, complete genome	16251-16280	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448963	Streptococcus phage Javan498, complete genome	13512-13541	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448773	Streptococcus phage Javan485, complete genome	19137-19166	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448911	Streptococcus phage Javan34, complete genome	20259-20288	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448837	Streptococcus phage Javan10, complete genome	18305-18334	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448742	Streptococcus phage Javan37, complete genome	20096-20125	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MH853358	Streptococcus phage LF4, complete genome	10633-10662	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448845	Streptococcus phage Javan118, complete genome	18668-18697	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448916	Streptococcus phage Javan36, complete genome	20259-20288	0	1.0
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448853	Streptococcus phage Javan144, complete genome	18198-18227	0	1.0
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448771	Streptococcus phage Javan481, complete genome	6935-6966	0	1.0
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448681	Streptococcus phage Javan141, complete genome	6533-6564	0	1.0
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448944	Streptococcus phage Javan452, complete genome	11199-11230	0	1.0
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448672	Streptococcus phage Javan117, complete genome	6781-6812	0	1.0
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448849	Streptococcus phage Javan128, complete genome	6684-6715	0	1.0
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448774	Streptococcus phage Javan487, complete genome	6920-6951	0	1.0
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448958	Streptococcus phage Javan486, complete genome	9164-9195	0	1.0
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448742	Streptococcus phage Javan37, complete genome	9156-9187	0	1.0
NZ_CP011068_3	3.2\|1325708\|33\|NZ_CP011068\|PILER-CR	1325708-1325740	33	MK448762	Streptococcus phage Javan447, complete genome	56-88	0	1.0
NZ_CP011068_3	3.2\|1325708\|33\|NZ_CP011068\|PILER-CR	1325708-1325740	33	MK448798	Streptococcus phage Javan533, complete genome	56-88	0	1.0
NZ_CP011068_3	3.2\|1325708\|33\|NZ_CP011068\|PILER-CR	1325708-1325740	33	MK448793	Streptococcus phage Javan523, complete genome	56-88	0	1.0
NZ_CP011068_3	3.2\|1325708\|33\|NZ_CP011068\|PILER-CR	1325708-1325740	33	MK448967	Streptococcus phage Javan510, complete genome	56-88	0	1.0
NZ_CP011068_3	3.2\|1325708\|33\|NZ_CP011068\|PILER-CR	1325708-1325740	33	MK448954	Streptococcus phage Javan476, complete genome	56-88	0	1.0
NZ_CP011068_3	3.2\|1325708\|33\|NZ_CP011068\|PILER-CR	1325708-1325740	33	NC_004588	Streptococcus prophage 315.5, complete genome	205-237	0	1.0
NZ_CP011068_4	4.1\|1908434\|45\|NZ_CP011068\|CRISPRCasFinder	1908434-1908478	45	MK448522	Streptococcus satellite phage Javan519, complete genome	1870-1914	0	1.0
NZ_CP011068_4	4.1\|1908434\|45\|NZ_CP011068\|CRISPRCasFinder	1908434-1908478	45	MK448330	Streptococcus satellite phage Javan136, complete genome	2770-2814	0	1.0
NZ_CP011068_4	4.1\|1908434\|45\|NZ_CP011068\|CRISPRCasFinder	1908434-1908478	45	MK448328	Streptococcus satellite phage Javan130, complete genome	2770-2814	0	1.0
NZ_CP011068_4	4.1\|1908434\|45\|NZ_CP011068\|CRISPRCasFinder	1908434-1908478	45	MK448513	Streptococcus satellite phage Javan479, complete genome	1870-1914	0	1.0
NZ_CP011068_4	4.1\|1908434\|45\|NZ_CP011068\|CRISPRCasFinder	1908434-1908478	45	MK448332	Streptococcus satellite phage Javan142, complete genome	2777-2821	0	1.0
NZ_CP011068_4	4.1\|1908434\|45\|NZ_CP011068\|CRISPRCasFinder	1908434-1908478	45	MK448331	Streptococcus satellite phage Javan138, complete genome	2777-2821	0	1.0
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	MK448946	Streptococcus phage Javan456, complete genome	26948-26977	1	0.967
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448946	Streptococcus phage Javan456, complete genome	36512-36541	1	0.967
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448779	Streptococcus phage Javan497, complete genome	31741-31770	1	0.967
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448795	Streptococcus phage Javan527, complete genome	38519-38548	1	0.967
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448944	Streptococcus phage Javan452, complete genome	35553-35582	1	0.967
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448968	Streptococcus phage Javan512, complete genome	31741-31770	1	0.967
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	NC_004584	Streptococcus prophage 315.1, complete genome	31585-31614	1	0.967
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448797	Streptococcus phage Javan531, complete genome	31741-31770	1	0.967
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448978	Streptococcus phage Javan532, complete genome	31479-31508	1	0.967
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448785	Streptococcus phage Javan507, complete genome	31480-31509	1	0.967
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	NC_004589	Streptococcus prophage 315.6, complete genome	31838-31867	1	0.967
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448767	Streptococcus phage Javan467, complete genome	6873-6904	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448973	Streptococcus phage Javan522, complete genome	8840-8871	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448862	Streptococcus phage Javan178, complete genome	6909-6940	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448942	Streptococcus phage Javan448, complete genome	6872-6903	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK449010	Streptococcus phage Javan90, complete genome	9368-9399	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK449012	Streptococcus phage Javan94, complete genome	8202-8233	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	NC_004586	Streptococcus pyogenes phage 315.3, complete genome	6978-7009	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448969	Streptococcus phage Javan514, complete genome	9628-9659	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448943	Streptococcus phage Javan450, complete genome	6873-6904	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448972	Streptococcus phage Javan520, complete genome	6682-6713	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448786	Streptococcus phage Javan509, complete genome	6873-6904	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448778	Streptococcus phage Javan493, complete genome	8855-8886	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448963	Streptococcus phage Javan498, complete genome	3462-3493	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448773	Streptococcus phage Javan485, complete genome	9628-9659	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448851	Streptococcus phage Javan14, complete genome	12141-12172	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448833	Streptococcus phage Javan87, complete genome	9368-9399	1	0.969
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448673	Streptococcus phage Javan119, complete genome	9947-9978	1	0.969
NZ_CP011068_4	4.1\|1908434\|45\|NZ_CP011068\|CRISPRCasFinder	1908434-1908478	45	MK448333	Streptococcus satellite phage Javan145, complete genome	2769-2813	1	0.978
NZ_CP011068_4	4.1\|1908434\|45\|NZ_CP011068\|CRISPRCasFinder	1908434-1908478	45	MK448340	Streptococcus satellite phage Javan156, complete genome	2769-2813	1	0.978
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	MK448933	Streptococcus phage Javan420, complete genome	26823-26852	2	0.933
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448771	Streptococcus phage Javan481, complete genome	26991-27020	2	0.933
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448942	Streptococcus phage Javan448, complete genome	18422-18451	2	0.933
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448794	Streptococcus phage Javan525, complete genome	32018-32047	2	0.933
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448964	Streptococcus phage Javan502, complete genome	27279-27308	2	0.933
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	M19348	Streptococcus pyogenes phage H4489A hyaluronidase (hylP) and hypothetical protein genes, complete cds	511-540	2	0.933
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448951	Streptococcus phage Javan470, complete genome	32170-32199	2	0.933
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448765	Streptococcus phage Javan459, complete genome	32016-32045	2	0.933
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448764	Streptococcus phage Javan457, complete genome	25122-25151	2	0.933
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448755	Streptococcus phage Javan423, complete genome	19783-19812	2	0.933
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	MK448756	Streptococcus phage Javan425, complete genome	19783-19812	2	0.933
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448964	Streptococcus phage Javan502, complete genome	6852-6883	2	0.938
NZ_CP011068_2	2.4\|777195\|30\|NZ_CP011068\|CRISPRCasFinder,CRT	777195-777224	30	NC_028666	Streptococcus phage Str-PAP-1, complete genome	24240-24269	3	0.9
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	NZ_CP020429	Streptococcus sp. FDAARGOS_192 plasmid unnamed1, complete sequence	100886-100917	3	0.906
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	NZ_CP020439	Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence	133703-133734	3	0.906
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	NZ_CP018188	Streptococcus salivarius strain ICDC2 plasmid, complete sequence	108972-109003	3	0.906
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MN480762	Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence	18925-18956	3	0.906
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MN480763	Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence	119911-119942	3	0.906
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448698	Streptococcus phage Javan187, complete genome	27333-27362	4	0.867
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448767	Streptococcus phage Javan467, complete genome	27472-27501	5	0.833
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	NC_004586	Streptococcus pyogenes phage 315.3, complete genome	27577-27606	5	0.833
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448976	Streptococcus phage Javan528, complete genome	32036-32065	5	0.833
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448943	Streptococcus phage Javan450, complete genome	27472-27501	5	0.833
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448972	Streptococcus phage Javan520, complete genome	27647-27676	5	0.833
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448786	Streptococcus phage Javan509, complete genome	27472-27501	5	0.833
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448963	Streptococcus phage Javan498, complete genome	23094-23123	5	0.833
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448773	Streptococcus phage Javan485, complete genome	28601-28630	5	0.833
NZ_CP011068_3	3.1\|1325643\|32\|NZ_CP011068\|PILER-CR	1325643-1325674	32	MK448845	Streptococcus phage Javan118, complete genome	8662-8693	5	0.844
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MK448950	Streptococcus phage Javan464, complete genome	32684-32713	6	0.8
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	MN693570	Marine virus AFVG_25M8, complete genome	48011-48040	6	0.8
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	NZ_CP014852	Bacillus thuringiensis strain HD12 plasmid pHD120161, complete sequence	135700-135729	7	0.767
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	NC_010895	Bacillus thuringiensis serovar tenebrionis plasmid pBMB175, complete sequence	869-898	7	0.767
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	CP020760	Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-21, complete sequence	3892-3921	7	0.767
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	NC_005567	Bacillus thuringiensis H1.1 plasmid pGI3, complete sequence	1823-1852	7	0.767
NZ_CP011068_2	2.1\|776997\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	776997-777026	30	NC_021559	Prochlorococcus phage P-SSM3 genomic sequence	77011-77040	8	0.733
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	NZ_CP031836	Lactobacillus amylolyticus strain L5 plasmid p1, complete sequence	84673-84702	8	0.733
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	NZ_CP020458	Lactobacillus amylolyticus strain L6 plasmid pL6-1, complete sequence	86560-86589	8	0.733
NZ_CP011068_2	2.3\|777129\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777129-777158	30	NC_013792	Bacillus pseudofirmus OF4 plasmid pBpOF4-01, complete sequence	63431-63460	8	0.733
NZ_CP011068_2	2.2\|777063\|30\|NZ_CP011068\|PILER-CR,CRISPRCasFinder,CRT	777063-777092	30	MN694808	Marine virus AFVG_250M14, complete genome	476-505	9	0.7

1. spacer 2.1|776997|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448662 (Streptococcus satellite phage Javan97, complete genome) position: , mismatch: 0, identity: 1.0

tgctccagatggatttttaaactgattatt	CRISPR spacer
tgctccagatggatttttaaactgattatt	Protospacer
******************************

2. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448775 (Streptococcus phage Javan489, complete genome) position: , mismatch: 0, identity: 1.0

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
tagaaattgacaatgctttttcttttgtct	Protospacer
******************************

3. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448794 (Streptococcus phage Javan525, complete genome) position: , mismatch: 0, identity: 1.0

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
tagaaattgacaatgctttttcttttgtct	Protospacer
******************************

4. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448953 (Streptococcus phage Javan474, complete genome) position: , mismatch: 0, identity: 1.0

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
tagaaattgacaatgctttttcttttgtct	Protospacer
******************************

5. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448765 (Streptococcus phage Javan459, complete genome) position: , mismatch: 0, identity: 1.0

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
tagaaattgacaatgctttttcttttgtct	Protospacer
******************************

6. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448957 (Streptococcus phage Javan484, complete genome) position: , mismatch: 0, identity: 1.0

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
tagaaattgacaatgctttttcttttgtct	Protospacer
******************************

7. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448871 (Streptococcus phage Javan196, complete genome) position: , mismatch: 0, identity: 1.0

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttgac	Protospacer
******************************

8. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448697 (Streptococcus phage Javan185, complete genome) position: , mismatch: 0, identity: 1.0

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttgac	Protospacer
******************************

9. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448693 (Streptococcus phage Javan177, complete genome) position: , mismatch: 0, identity: 1.0

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttgac	Protospacer
******************************

10. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448772 (Streptococcus phage Javan483, complete genome) position: , mismatch: 0, identity: 1.0

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttgac	Protospacer
******************************

11. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448696 (Streptococcus phage Javan183, complete genome) position: , mismatch: 0, identity: 1.0

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttgac	Protospacer
******************************

12. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to NC_009819 (Streptococcus phage P9, complete genome) position: , mismatch: 0, identity: 1.0

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttgac	Protospacer
******************************

13. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448793 (Streptococcus phage Javan523, complete genome) position: , mismatch: 0, identity: 1.0

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttgac	Protospacer
******************************

14. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448868 (Streptococcus phage Javan188, complete genome) position: , mismatch: 0, identity: 1.0

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttgac	Protospacer
******************************

15. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448866 (Streptococcus phage Javan184, complete genome) position: , mismatch: 0, identity: 1.0

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttgac	Protospacer
******************************

16. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448954 (Streptococcus phage Javan476, complete genome) position: , mismatch: 0, identity: 1.0

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttgac	Protospacer
******************************

17. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448699 (Streptococcus phage Javan189, complete genome) position: , mismatch: 0, identity: 1.0

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttgac	Protospacer
******************************

18. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448867 (Streptococcus phage Javan186, complete genome) position: , mismatch: 0, identity: 1.0

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttgac	Protospacer
******************************

19. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448767 (Streptococcus phage Javan467, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

20. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448685 (Streptococcus phage Javan155, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

21. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448771 (Streptococcus phage Javan481, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

22. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448829 (Streptococcus phage Javan7, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

23. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448736 (Streptococcus phage Javan35, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

24. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448781 (Streptococcus phage Javan5, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

25. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK449012 (Streptococcus phage Javan94, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

26. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to NC_004586 (Streptococcus pyogenes phage 315.3, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

27. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448969 (Streptococcus phage Javan514, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

28. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MH853355 (Streptococcus phage LF1, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

29. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448964 (Streptococcus phage Javan502, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

30. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448943 (Streptococcus phage Javan450, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

31. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448972 (Streptococcus phage Javan520, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

32. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448938 (Streptococcus phage Javan44, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

33. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448855 (Streptococcus phage Javan150, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

34. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448786 (Streptococcus phage Javan509, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

35. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448774 (Streptococcus phage Javan487, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

36. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448963 (Streptococcus phage Javan498, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

37. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448773 (Streptococcus phage Javan485, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

38. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448911 (Streptococcus phage Javan34, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

39. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448837 (Streptococcus phage Javan10, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

40. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448742 (Streptococcus phage Javan37, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

41. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MH853358 (Streptococcus phage LF4, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

42. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448845 (Streptococcus phage Javan118, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

43. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448916 (Streptococcus phage Javan36, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

44. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448853 (Streptococcus phage Javan144, complete genome) position: , mismatch: 0, identity: 1.0

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatattaacgtcctttctcctgctttcc	Protospacer
******************************

45. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448771 (Streptococcus phage Javan481, complete genome) position: , mismatch: 0, identity: 1.0

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagaagctcatgaa	Protospacer
********************************

46. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448681 (Streptococcus phage Javan141, complete genome) position: , mismatch: 0, identity: 1.0

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagaagctcatgaa	Protospacer
********************************

47. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448944 (Streptococcus phage Javan452, complete genome) position: , mismatch: 0, identity: 1.0

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagaagctcatgaa	Protospacer
********************************

48. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448672 (Streptococcus phage Javan117, complete genome) position: , mismatch: 0, identity: 1.0

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagaagctcatgaa	Protospacer
********************************

49. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448849 (Streptococcus phage Javan128, complete genome) position: , mismatch: 0, identity: 1.0

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagaagctcatgaa	Protospacer
********************************

50. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448774 (Streptococcus phage Javan487, complete genome) position: , mismatch: 0, identity: 1.0

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagaagctcatgaa	Protospacer
********************************

51. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448958 (Streptococcus phage Javan486, complete genome) position: , mismatch: 0, identity: 1.0

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagaagctcatgaa	Protospacer
********************************

52. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448742 (Streptococcus phage Javan37, complete genome) position: , mismatch: 0, identity: 1.0

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagaagctcatgaa	Protospacer
********************************

53. spacer 3.2|1325708|33|NZ_CP011068|PILER-CR matches to MK448762 (Streptococcus phage Javan447, complete genome) position: , mismatch: 0, identity: 1.0

atgtgggtgtattggctagtcatgtaattattt	CRISPR spacer
atgtgggtgtattggctagtcatgtaattattt	Protospacer
*********************************

54. spacer 3.2|1325708|33|NZ_CP011068|PILER-CR matches to MK448798 (Streptococcus phage Javan533, complete genome) position: , mismatch: 0, identity: 1.0

atgtgggtgtattggctagtcatgtaattattt	CRISPR spacer
atgtgggtgtattggctagtcatgtaattattt	Protospacer
*********************************

55. spacer 3.2|1325708|33|NZ_CP011068|PILER-CR matches to MK448793 (Streptococcus phage Javan523, complete genome) position: , mismatch: 0, identity: 1.0

atgtgggtgtattggctagtcatgtaattattt	CRISPR spacer
atgtgggtgtattggctagtcatgtaattattt	Protospacer
*********************************

56. spacer 3.2|1325708|33|NZ_CP011068|PILER-CR matches to MK448967 (Streptococcus phage Javan510, complete genome) position: , mismatch: 0, identity: 1.0

atgtgggtgtattggctagtcatgtaattattt	CRISPR spacer
atgtgggtgtattggctagtcatgtaattattt	Protospacer
*********************************

57. spacer 3.2|1325708|33|NZ_CP011068|PILER-CR matches to MK448954 (Streptococcus phage Javan476, complete genome) position: , mismatch: 0, identity: 1.0

atgtgggtgtattggctagtcatgtaattattt	CRISPR spacer
atgtgggtgtattggctagtcatgtaattattt	Protospacer
*********************************

58. spacer 3.2|1325708|33|NZ_CP011068|PILER-CR matches to NC_004588 (Streptococcus prophage 315.5, complete genome) position: , mismatch: 0, identity: 1.0

atgtgggtgtattggctagtcatgtaattattt	CRISPR spacer
atgtgggtgtattggctagtcatgtaattattt	Protospacer
*********************************

59. spacer 4.1|1908434|45|NZ_CP011068|CRISPRCasFinder matches to MK448522 (Streptococcus satellite phage Javan519, complete genome) position: , mismatch: 0, identity: 1.0

ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	CRISPR spacer
ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	Protospacer
*********************************************

60. spacer 4.1|1908434|45|NZ_CP011068|CRISPRCasFinder matches to MK448330 (Streptococcus satellite phage Javan136, complete genome) position: , mismatch: 0, identity: 1.0

ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	CRISPR spacer
ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	Protospacer
*********************************************

61. spacer 4.1|1908434|45|NZ_CP011068|CRISPRCasFinder matches to MK448328 (Streptococcus satellite phage Javan130, complete genome) position: , mismatch: 0, identity: 1.0

ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	CRISPR spacer
ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	Protospacer
*********************************************

62. spacer 4.1|1908434|45|NZ_CP011068|CRISPRCasFinder matches to MK448513 (Streptococcus satellite phage Javan479, complete genome) position: , mismatch: 0, identity: 1.0

ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	CRISPR spacer
ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	Protospacer
*********************************************

63. spacer 4.1|1908434|45|NZ_CP011068|CRISPRCasFinder matches to MK448332 (Streptococcus satellite phage Javan142, complete genome) position: , mismatch: 0, identity: 1.0

ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	CRISPR spacer
ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	Protospacer
*********************************************

64. spacer 4.1|1908434|45|NZ_CP011068|CRISPRCasFinder matches to MK448331 (Streptococcus satellite phage Javan138, complete genome) position: , mismatch: 0, identity: 1.0

ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	CRISPR spacer
ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	Protospacer
*********************************************

65. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448946 (Streptococcus phage Javan456, complete genome) position: , mismatch: 1, identity: 0.967

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
cagaaattgacaatgctttttcttttgtct	Protospacer
.*****************************

66. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448946 (Streptococcus phage Javan456, complete genome) position: , mismatch: 1, identity: 0.967

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctaaacaaaaaattgagtttgac	Protospacer
**********.*******************

67. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448779 (Streptococcus phage Javan497, complete genome) position: , mismatch: 1, identity: 0.967

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttggc	Protospacer
****************************.*

68. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448795 (Streptococcus phage Javan527, complete genome) position: , mismatch: 1, identity: 0.967

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttggc	Protospacer
****************************.*

69. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448944 (Streptococcus phage Javan452, complete genome) position: , mismatch: 1, identity: 0.967

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttggc	Protospacer
****************************.*

70. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448968 (Streptococcus phage Javan512, complete genome) position: , mismatch: 1, identity: 0.967

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttggc	Protospacer
****************************.*

71. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to NC_004584 (Streptococcus prophage 315.1, complete genome) position: , mismatch: 1, identity: 0.967

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttggc	Protospacer
****************************.*

72. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448797 (Streptococcus phage Javan531, complete genome) position: , mismatch: 1, identity: 0.967

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttggc	Protospacer
****************************.*

73. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448978 (Streptococcus phage Javan532, complete genome) position: , mismatch: 1, identity: 0.967

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttggc	Protospacer
****************************.*

74. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448785 (Streptococcus phage Javan507, complete genome) position: , mismatch: 1, identity: 0.967

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttggc	Protospacer
****************************.*

75. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to NC_004589 (Streptococcus prophage 315.6, complete genome) position: , mismatch: 1, identity: 0.967

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagtttggc	Protospacer
****************************.*

76. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448767 (Streptococcus phage Javan467, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaaaaagctcatgaa	Protospacer
********************.***********

77. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448973 (Streptococcus phage Javan522, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaaaaagctcatgaa	Protospacer
********************.***********

78. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448862 (Streptococcus phage Javan178, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagcagctcatgaa	Protospacer
********************* **********

79. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448942 (Streptococcus phage Javan448, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaaaaagctcatgaa	Protospacer
********************.***********

80. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK449010 (Streptococcus phage Javan90, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaaaaagctcatgaa	Protospacer
********************.***********

81. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK449012 (Streptococcus phage Javan94, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaaaaagctcatgaa	Protospacer
********************.***********

82. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to NC_004586 (Streptococcus pyogenes phage 315.3, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaaaaagctcatgaa	Protospacer
********************.***********

83. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448969 (Streptococcus phage Javan514, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagcagctcatgaa	Protospacer
********************* **********

84. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448943 (Streptococcus phage Javan450, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaaaaagctcatgaa	Protospacer
********************.***********

85. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448972 (Streptococcus phage Javan520, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagcagctcatgaa	Protospacer
********************* **********

86. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448786 (Streptococcus phage Javan509, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaaaaagctcatgaa	Protospacer
********************.***********

87. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448778 (Streptococcus phage Javan493, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaaaaagctcatgaa	Protospacer
********************.***********

88. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448963 (Streptococcus phage Javan498, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaaaaagctcatgaa	Protospacer
********************.***********

89. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448773 (Streptococcus phage Javan485, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagcagctcatgaa	Protospacer
********************* **********

90. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448851 (Streptococcus phage Javan14, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagcagctcatgaa	Protospacer
********************* **********

91. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448833 (Streptococcus phage Javan87, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaaaaagctcatgaa	Protospacer
********************.***********

92. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448673 (Streptococcus phage Javan119, complete genome) position: , mismatch: 1, identity: 0.969

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagcagctcatgaa	Protospacer
********************* **********

93. spacer 4.1|1908434|45|NZ_CP011068|CRISPRCasFinder matches to MK448333 (Streptococcus satellite phage Javan145, complete genome) position: , mismatch: 1, identity: 0.978

ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	CRISPR spacer
ttttgcaaaatctatattaacgcaaataaatttggttgccaagat	Protospacer
**************************************.******

94. spacer 4.1|1908434|45|NZ_CP011068|CRISPRCasFinder matches to MK448340 (Streptococcus satellite phage Javan156, complete genome) position: , mismatch: 1, identity: 0.978

ttttgcaaaatctatattaacgcaaataaatttggttgtcaagat	CRISPR spacer
ttttgcaaaatctatattaacgcaaataaatttggttgccaagat	Protospacer
**************************************.******

95. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448933 (Streptococcus phage Javan420, complete genome) position: , mismatch: 2, identity: 0.933

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
cagagattgacaatgctttttcttttgtct	Protospacer
.***.*************************

96. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448771 (Streptococcus phage Javan481, complete genome) position: , mismatch: 2, identity: 0.933

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagcttaac	Protospacer
************************.**.**

97. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448942 (Streptococcus phage Javan448, complete genome) position: , mismatch: 2, identity: 0.933

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagcttaac	Protospacer
************************.**.**

98. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448794 (Streptococcus phage Javan525, complete genome) position: , mismatch: 2, identity: 0.933

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagcttaac	Protospacer
************************.**.**

99. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448964 (Streptococcus phage Javan502, complete genome) position: , mismatch: 2, identity: 0.933

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagcttaac	Protospacer
************************.**.**

100. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to M19348 (Streptococcus pyogenes phage H4489A hyaluronidase (hylP) and hypothetical protein genes, complete cds) position: , mismatch: 2, identity: 0.933

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagcttaac	Protospacer
************************.**.**

101. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448951 (Streptococcus phage Javan470, complete genome) position: , mismatch: 2, identity: 0.933

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctaaacaaaaaattgaatttgac	Protospacer
**********.************.******

102. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448765 (Streptococcus phage Javan459, complete genome) position: , mismatch: 2, identity: 0.933

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagcttaac	Protospacer
************************.**.**

103. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448764 (Streptococcus phage Javan457, complete genome) position: , mismatch: 2, identity: 0.933

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
aatagagctagacaaaaaattgagcttaac	Protospacer
************************.**.**

104. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448755 (Streptococcus phage Javan423, complete genome) position: , mismatch: 2, identity: 0.933

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatgataacgtcctttctcctgctttcc	Protospacer
*****. ***********************

105. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to MK448756 (Streptococcus phage Javan425, complete genome) position: , mismatch: 2, identity: 0.933

gacatattaacgtcctttctcctgctttcc	CRISPR spacer
gacatgataacgtcctttctcctgctttcc	Protospacer
*****. ***********************

106. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448964 (Streptococcus phage Javan502, complete genome) position: , mismatch: 2, identity: 0.938

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagggtaaaaaagctcatgaa	Protospacer
**************.*****.***********

107. spacer 2.4|777195|30|NZ_CP011068|CRISPRCasFinder,CRT matches to NC_028666 (Streptococcus phage Str-PAP-1, complete genome) position: , mismatch: 3, identity: 0.9

-gacatattaacgtcctttctcctgctttcc	CRISPR spacer
tgacatg-taacgtcctttctcctgctttgc	Protospacer
 *****. ********************* *

108. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to NZ_CP020429 (Streptococcus sp. FDAARGOS_192 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.906

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
attcttattttgagactaaagaagctcatgaa	Protospacer
*.*****.******* ****************

109. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to NZ_CP020439 (Streptococcus equinus strain FDAARGOS_251 plasmid unamed1 sequence) position: , mismatch: 3, identity: 0.906

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
attcttattttgagactaaagaagctcatgaa	Protospacer
*.*****.******* ****************

110. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to NZ_CP018188 (Streptococcus salivarius strain ICDC2 plasmid, complete sequence) position: , mismatch: 3, identity: 0.906

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
attcttattttgagaataaagaagctcatgaa	Protospacer
*.*****.*******.****************

111. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MN480762 (Streptococcus salivarius strain NU10 plasmid pSsal-NU10, complete sequence) position: , mismatch: 3, identity: 0.906

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
attcttattttgagaataaagaagctcatgaa	Protospacer
*.*****.*******.****************

112. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MN480763 (Streptococcus salivarius strain YU10 plasmid pSsal-YU10, complete sequence) position: , mismatch: 3, identity: 0.906

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
attcttattttgagactaaagaagctcatgaa	Protospacer
*.*****.******* ****************

113. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448698 (Streptococcus phage Javan187, complete genome) position: , mismatch: 4, identity: 0.867

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
tgcaaagctagacaaaaaattgagtttgac	Protospacer
 ..*.*************************

114. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448767 (Streptococcus phage Javan467, complete genome) position: , mismatch: 5, identity: 0.833

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
tgcaaagctagacgaaaaattgagtttgac	Protospacer
 ..*.********.****************

115. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to NC_004586 (Streptococcus pyogenes phage 315.3, complete genome) position: , mismatch: 5, identity: 0.833

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
tgcaaagctagacgaaaaattgagtttgac	Protospacer
 ..*.********.****************

116. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448976 (Streptococcus phage Javan528, complete genome) position: , mismatch: 5, identity: 0.833

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
tgcaaagctagacgaaaaattgagtttgac	Protospacer
 ..*.********.****************

117. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448943 (Streptococcus phage Javan450, complete genome) position: , mismatch: 5, identity: 0.833

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
tgcaaagctagacgaaaaattgagtttgac	Protospacer
 ..*.********.****************

118. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448972 (Streptococcus phage Javan520, complete genome) position: , mismatch: 5, identity: 0.833

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
tgcaaagctagacgaaaaattgagtttgac	Protospacer
 ..*.********.****************

119. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448786 (Streptococcus phage Javan509, complete genome) position: , mismatch: 5, identity: 0.833

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
tgcaaagctagacgaaaaattgagtttgac	Protospacer
 ..*.********.****************

120. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448963 (Streptococcus phage Javan498, complete genome) position: , mismatch: 5, identity: 0.833

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
tgcaaagctagacgaaaaattgagtttgac	Protospacer
 ..*.********.****************

121. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448773 (Streptococcus phage Javan485, complete genome) position: , mismatch: 5, identity: 0.833

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
tgcaaagctagacgaaaaattgagtttgac	Protospacer
 ..*.********.****************

122. spacer 3.1|1325643|32|NZ_CP011068|PILER-CR matches to MK448845 (Streptococcus phage Javan118, complete genome) position: , mismatch: 5, identity: 0.844

actcttactttgagagtaaagaagctcatgaa	CRISPR spacer
actcttactttgagagtaaagcagcttattcc	Protospacer
********************* ****.**

123. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MK448950 (Streptococcus phage Javan464, complete genome) position: , mismatch: 6, identity: 0.8

aatagagctagacaaaaaattgagtttgac	CRISPR spacer
tgcaaagctagacggaaaattgagtttgac	Protospacer
 ..*.********..***************

124. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MN693570 (Marine virus AFVG_25M8, complete genome) position: , mismatch: 6, identity: 0.8

aataga-gctagacaaaaaattgagtttgac	CRISPR spacer
-ttacatgctagtcaaaaaattgagtttaat	Protospacer
  ** * ***** ***************.*.

125. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014852 (Bacillus thuringiensis strain HD12 plasmid pHD120161, complete sequence) position: , mismatch: 7, identity: 0.767

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
cggaaattgacaatgcttttgcttctggtg	Protospacer
..****************** ***.** .

126. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to NC_010895 (Bacillus thuringiensis serovar tenebrionis plasmid pBMB175, complete sequence) position: , mismatch: 7, identity: 0.767

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
agtaaattgataattctttttcttttcttt	Protospacer
 . *******.*** *********** *.*

127. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to CP020760 (Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-21, complete sequence) position: , mismatch: 7, identity: 0.767

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
ggtaaattgataattctttttcttttcttt	Protospacer
 . *******.*** *********** *.*

128. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to NC_005567 (Bacillus thuringiensis H1.1 plasmid pGI3, complete sequence) position: , mismatch: 7, identity: 0.767

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
ggtaaattgataattctttttcttttcttt	Protospacer
 . *******.*** *********** *.*

129. spacer 2.1|776997|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to NC_021559 (Prochlorococcus phage P-SSM3 genomic sequence) position: , mismatch: 8, identity: 0.733

tgctccagatggatttttaaactgattatt	CRISPR spacer
catttgagatggatttttaaacttcttata	Protospacer
...*. *****************  ****

130. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031836 (Lactobacillus amylolyticus strain L5 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.733

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
gtctaattgacgatgctttttcttttttta	Protospacer
    *******.************** *.

131. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020458 (Lactobacillus amylolyticus strain L6 plasmid pL6-1, complete sequence) position: , mismatch: 8, identity: 0.733

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
gtctaattgacgatgctttttcttttttta	Protospacer
    *******.************** *.

132. spacer 2.3|777129|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to NC_013792 (Bacillus pseudofirmus OF4 plasmid pBpOF4-01, complete sequence) position: , mismatch: 8, identity: 0.733

aatagagctagacaaaaaattgagtttgac---	CRISPR spacer
aatagagctagacaagaaatta---tcaaaagg	Protospacer
***************.*****.   *..*

133. spacer 2.2|777063|30|NZ_CP011068|PILER-CR,CRISPRCasFinder,CRT matches to MN694808 (Marine virus AFVG_250M14, complete genome) position: , mismatch: 9, identity: 0.7

tagaaattgacaatgctttttcttttgtct	CRISPR spacer
agggtattgacaatcctttttcttttcctg	Protospacer
 .*. ********* *********** ..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

36515 : 48828

Synechococcus_phage(28.57%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002987703.1\|36515_40241_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	1.1e-38	26.3
WP_021340854.1\|40401_41856_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.8e-54	32.7
WP_011284404.1\|41883_42906_+	phosphoribosylformylglycinamidine cyclo-ligase	R9TMC7	Synechococcus_phage	2.4e-63	42.1
WP_002987709.1\|43073_43628_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.8e-25	35.6
WP_002987711.1\|43811_45359_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	E3SNU8	Prochlorococcus_phage	3.4e-45	52.4
WP_002987712.1\|45416_46541_-	CHAP domain-containing protein	F8HGP2	Streptococcus_phage	7.7e-07	28.6
WP_021340857.1\|46793_48059_+	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
WP_002987716.1\|48336_48828_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	3.2e-18	42.3

DBSCAN-SWA_2

337812 : 343686

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002990917.1\|337812_338448_+	dTMP kinase	M1PSC7	Streptococcus_phage	2.7e-65	63.4
WP_002985844.1\|338465_339341_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	2.1e-68	46.6
WP_002985838.1\|339843_340167_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	1.3e-28	59.4
WP_002985836.1\|340171_341035_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	1.7e-115	75.0
WP_002985833.1\|341061_341454_+	hypothetical protein	NA	NA	NA	NA
WP_011284535.1\|341500_342130_-	copper homeostasis protein CutC	NA	NA	NA	NA
WP_011284536.1\|342428_342785_+	arsenate reductase family protein	M1PLC0	Streptococcus_phage	6.3e-40	65.8
WP_021340916.1\|342858_343686_-	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	1.7e-128	79.9

DBSCAN-SWA_3

621864 : 629265

Streptococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_030126548.1\|621864_624075_-	LTA synthase family protein	W6LM83	Streptococcus_phage	2.5e-267	68.8
WP_011284674.1\|624182_625346_+	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	4.5e-143	64.9
WP_002985140.1\|625342_626029_+	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	7.0e-88	68.9
WP_002990262.1\|626122_627289_+	chorismate synthase	A0A291AU41	Pandoravirus	4.5e-34	32.8
WP_002990260.1\|627349_627691_+	YlbF/YmcA family competence regulator	A0A1X9I5Y8	Streptococcus_phage	2.6e-19	41.1
WP_011284677.1\|627912_629265_+	glutathione-disulfide reductase	A0A2K5B2C5	Erysipelothrix_phage	1.0e-29	24.7

DBSCAN-SWA_4

979378 : 1035333

Streptococcus_phage(43.86%)

head,portal,terminase,tail,integrase

attL 1015490:1015505|attR 1037111:1037126

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011284836.1\|979378_982489_-	DNA polymerase III subunit alpha	A0A2L1IZ23	Streptomyces_phage	5.4e-119	29.7
WP_002989617.1\|982673_983045_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_002984437.1\|983044_983743_+	ABC transporter ATP-binding protein	F2Y2R6	Organic_Lake_phycodnavirus	6.6e-09	27.3
WP_002984433.1\|983752_984538_+	hypothetical protein	NA	NA	NA	NA
WP_002989607.1\|984664_985279_-	TVP38/TMEM64 family protein	M1Q152	Streptococcus_phage	6.2e-51	52.3
WP_002993136.1\|985869_986058_-	hypothetical protein	A3F673	Streptococcus_phage	2.1e-18	76.3
WP_011184727.1\|986297_987056_+	DNase Mf2	NA	NA	NA	NA
WP_002985327.1\|987166_987874_+	streptococcal pyrogenic exotoxin SpeC	A0A097PAT7	Streptococcus_pyogenes_phage	3.9e-09	27.1
WP_011284838.1\|987949_989284_-	lysin	Q5MY96	Streptococcus_phage	1.3e-247	93.0
WP_011284839.1\|989395_989581_-	hypothetical protein	Q938J5	Temperate_phage	6.6e-25	96.7
WP_002990012.1\|989577_989874_-	hypothetical protein	Q938J6	Temperate_phage	3.7e-46	98.0
WP_011284840.1\|989884_990502_-	hypothetical protein	A3F662	Streptococcus_phage	9.8e-89	94.6
WP_011284841.1\|990679_992575_-	hypothetical protein	Q938J9	Temperate_phage	5.9e-76	52.5
WP_021340983.1\|992585_992900_-	hypothetical protein	NA	NA	NA	NA
WP_011284843.1\|992901_994116_-	hypothetical protein	A3F657	Streptococcus_phage	5.0e-44	49.5
WP_047716000.1\|994112_996167_-	hypothetical protein	A3F656	Streptococcus_phage	0.0e+00	84.2
WP_011284845.1\|996163_996943_-	hypothetical protein	A3F655	Streptococcus_phage	1.9e-65	54.0
WP_011284846.1\|996974_1000610_-	tape measure protein	C5IUK3	Streptococcus_phage	1.2e-85	41.4
WP_021340179.1\|1000624_1000921_-	hypothetical protein	A0A0S2MYH1	Enterococcus_phage	1.3e-09	42.2
WP_002990023.1\|1000995_1001349_-	hypothetical protein	Q77RZ7	Lactococcus_phage	5.5e-20	48.6
WP_030126608.1\|1001402_1002026_-\|tail	phage major tail protein, TP901-1 family	D7RWD5	Brochothrix_phage	3.2e-39	50.5
WP_011284850.1\|1002080_1002470_-	hypothetical protein	B5SP36	Lactococcus_phage	4.2e-45	68.2
WP_030126607.1\|1002466_1002832_-	HK97 gp10 family phage protein	A0A097BY98	Enterococcus_phage	5.9e-17	46.3
WP_011284852.1\|1002812_1003121_-	hypothetical protein	A0A2P1JTW8	Anoxybacillus_phage	7.4e-13	40.2
WP_002984392.1\|1003117_1003471_-	hypothetical protein	A0A2H4J002	uncultured_Caudovirales_phage	9.7e-25	49.6
WP_011284854.1\|1003484_1003727_-	hypothetical protein	NA	NA	NA	NA
WP_011284855.1\|1003736_1004819_-	hypothetical protein	A0A2H4J022	uncultured_Caudovirales_phage	3.4e-105	57.1
WP_011284856.1\|1004821_1005202_-\|head	head decoration protein	A0A0K2CNR0	Brevibacillus_phage	1.8e-05	32.5
WP_023079765.1\|1005211_1005745_-	DUF4355 domain-containing protein	A0A141E0S7	Streptococcus_phage	6.8e-14	80.7
WP_011284858.1\|1005888_1006155_-	hypothetical protein	A0A097PAR8	Streptococcus_pyogenes_phage	1.9e-25	70.5
WP_011284859.1\|1006157_1006472_-	hypothetical protein	M1PLI3	Streptococcus_phage	6.8e-38	72.8
WP_002988389.1\|1006541_1006727_-	hypothetical protein	NA	NA	NA	NA
WP_011284860.1\|1006730_1008293_-\|head	phage head morphogenesis protein	U6E9F1	Streptococcus_phage	2.5e-48	44.2
WP_002984369.1\|1008273_1009776_-\|portal	phage portal protein	C9W9H5	Streptococcus_virus	1.9e-141	54.5
WP_020833530.1\|1009787_1011095_-\|terminase	PBSX family phage terminase large subunit	A0A2H4IYR5	uncultured_Caudovirales_phage	2.0e-184	75.7
WP_044564892.1\|1011072_1011540_-\|terminase	terminase small subunit	A0A141E1Y3	Streptococcus_phage	1.1e-52	70.8
WP_001132273.1\|1011602_1011788_+	addiction module toxin, HicA family	D6PSW1	Lactobacillus_phage	1.7e-09	54.0
WP_047716001.1\|1011839_1012217_+	pilus biosynthesis protein HicB	I3NLB2	Bifidobacterium_phage	9.7e-15	44.0
WP_002990048.1\|1012532_1012745_+	hypothetical protein	NA	NA	NA	NA
WP_011284864.1\|1012834_1013749_-	hypothetical protein	NA	NA	NA	NA
WP_011284866.1\|1014326_1014761_-	ArpU family transcriptional regulator	J7KDQ1	Streptococcus_phage	6.2e-74	97.9
WP_011888686.1\|1015209_1015689_-	DUF1642 domain-containing protein	A0A141E0J6	Streptococcus_phage	6.5e-24	41.9
1015490:1015505	attL	NA	NA	NA	NA
WP_011888685.1\|1015693_1016326_-	SAM-dependent DNA methyltransferase	L0P368	Streptococcus_phage	5.1e-85	68.6
WP_011284869.1\|1016327_1016612_-	hypothetical protein	A0A097PAV1	Streptococcus_pyogenes_phage	2.6e-36	86.2
WP_002995955.1\|1016775_1017012_-	DUF3310 domain-containing protein	A0A097PAQ7	Streptococcus_pyogenes_phage	2.4e-40	100.0
WP_011284873.1\|1017253_1017610_-	hypothetical protein	A0A097PAU4	Streptococcus_pyogenes_phage	2.9e-61	100.0
WP_023079767.1\|1017593_1017944_-	VRR-NUC domain-containing protein	A0A1P8VVL5	Streptococcus_phage	9.9e-46	88.5
WP_014635521.1\|1017897_1018767_-	hypothetical protein	A0A1P8BME8	Lactococcus_phage	5.8e-103	65.6
WP_011284875.1\|1019035_1020589_-	hypothetical protein	A0A1P8BM51	Lactococcus_phage	5.7e-210	70.6
WP_002984328.1\|1020606_1021089_-	DUF669 domain-containing protein	A0A1P8BM40	Lactococcus_phage	9.7e-60	70.7
WP_075340263.1\|1021093_1022497_-	DEAD/DEAH box helicase	A0A1P8BMH7	Lactococcus_phage	2.3e-194	72.3
WP_002984321.1\|1022532_1023216_-	AAA family ATPase	J7KC09	Streptococcus_phage	9.4e-125	99.1
WP_011284877.1\|1023212_1023497_-	hypothetical protein	NA	NA	NA	NA
WP_002984315.1\|1023493_1023688_-	hypothetical protein	J7KK69	Streptococcus_phage	3.9e-12	54.2
WP_011284878.1\|1023687_1024017_-	hypothetical protein	J7KBZ0	Streptococcus_phage	7.9e-13	41.8
WP_011017882.1\|1024231_1024528_-	hypothetical protein	A0A097PAT8	Streptococcus_pyogenes_phage	3.1e-48	98.0
WP_011054585.1\|1024606_1024792_-	helix-turn-helix transcriptional regulator	A0A1X9I6I3	Streptococcus_phage	3.3e-16	72.1
WP_011284879.1\|1024958_1025198_+	hypothetical protein	NA	NA	NA	NA
WP_002984292.1\|1025347_1025557_+	hypothetical protein	NA	NA	NA	NA
WP_011017884.1\|1025815_1026325_+	hypothetical protein	NA	NA	NA	NA
WP_002984281.1\|1026432_1026660_-	hypothetical protein	A0A141E1R7	Streptococcus_phage	2.9e-14	57.3
WP_011054589.1\|1026733_1027120_+	hypothetical protein	A0A097PAT1	Streptococcus_pyogenes_phage	1.2e-65	100.0
WP_011284881.1\|1027108_1027318_-	hypothetical protein	A0A097PAQ9	Streptococcus_pyogenes_phage	1.7e-32	100.0
WP_011284882.1\|1027371_1027971_+	hypothetical protein	A0A097PAT4	Streptococcus_pyogenes_phage	3.1e-108	100.0
WP_021341080.1\|1028217_1028433_+	hypothetical protein	J7KBX0	Streptococcus_phage	2.5e-28	95.7
WP_011284884.1\|1028925_1029669_+	helix-turn-helix domain-containing protein	A0A1S5S8T5	Streptococcus_phage	2.5e-75	62.9
WP_023079768.1\|1029681_1030491_+	toxin-antitoxin system toxin component MazF family	J7KDP1	Streptococcus_phage	2.9e-24	35.8
WP_023079773.1\|1030740_1031829_+\|integrase	site-specific integrase	Q38159	Streptococcus_phage	3.0e-202	98.6
WP_002989605.1\|1032191_1032812_+	DUF3862 domain-containing protein	NA	NA	NA	NA
WP_011284887.1\|1033068_1035333_-	glycogen/starch/alpha-glucan family phosphorylase	Q8B3H5	Iris_mild_mosaic_virus	1.2e-11	43.7
1037111:1037126	attR	NA	NA	NA	NA

DBSCAN-SWA_5

1278097 : 1322843

Temperate_phage(83.61%)

terminase,portal,capsid,integrase

attL 1303658:1303674|attR 1323022:1323038

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011284967.1\|1278097_1279831_-	sensor histidine kinase	Q9EYF3	Enterobacteria_phage	3.9e-26	33.2
WP_011054725.1\|1279827_1280568_-	response regulator	Q6XM27	Feldmannia_irregularis_virus	8.0e-05	32.4
WP_011054726.1\|1280812_1280995_-	hypothetical protein	A3F673	Streptococcus_phage	2.6e-18	76.7
WP_011106694.1\|1281059_1281347_-	hypothetical protein	Q938I9	Temperate_phage	2.4e-29	100.0
WP_011054727.1\|1281340_1281916_-	hypothetical protein	Q938J0	Temperate_phage	1.7e-111	100.0
WP_011054728.1\|1282391_1283171_-	streptococcal pyrogenic exotoxin SpeK	Q938J1	Temperate_phage	5.4e-145	100.0
WP_011054729.1\|1283474_1284341_-	DUF334 domain-containing protein	Q938J2	Temperate_phage	3.7e-134	100.0
WP_011017840.1\|1284328_1284853_-	DUF4065 domain-containing protein	Q938J3	Temperate_phage	4.0e-99	100.0
WP_011054730.1\|1284992_1286195_-	CHAP domain-containing protein	Q938J4	Temperate_phage	3.3e-242	100.0
WP_011054731.1\|1286305_1286491_-	hypothetical protein	Q938J5	Temperate_phage	1.7e-25	100.0
WP_011054732.1\|1286487_1286784_-	hypothetical protein	Q938J6	Temperate_phage	7.5e-47	100.0
WP_011054733.1\|1286794_1287406_-	DUF1366 domain-containing protein	Q938J7	Temperate_phage	2.7e-91	100.0
WP_002987513.1\|1287408_1287840_-	DUF1617 family protein	Q938J8	Temperate_phage	1.1e-73	100.0
WP_011284969.1\|1287851_1289738_-	hypothetical protein	Q938J9	Temperate_phage	1.9e-228	90.6
WP_021340983.1\|1289748_1290063_-	hypothetical protein	NA	NA	NA	NA
WP_011284843.1\|1290064_1291279_-	hypothetical protein	A3F657	Streptococcus_phage	5.0e-44	49.5
WP_047716034.1\|1291275_1293423_-	peptidase	Q938K1	Temperate_phage	0.0e+00	94.8
WP_011054737.1\|1293419_1294136_-	hypothetical protein	Q938K2	Temperate_phage	2.9e-137	100.0
WP_011054738.1\|1294132_1297393_-	tape measure protein	Q938K3	Temperate_phage	0.0e+00	99.9
WP_011054739.1\|1297382_1297964_-	hypothetical protein	Q938K4	Temperate_phage	1.3e-106	100.0
WP_011054740.1\|1297967_1298402_-	hypothetical protein	Q938K5	Temperate_phage	2.6e-72	100.0
WP_011054741.1\|1298440_1298926_-	hypothetical protein	Q938K6	Temperate_phage	1.6e-86	100.0
WP_010922084.1\|1298925_1299324_-\|capsid	phage capsid protein	Q79S87	Temperate_phage	3.5e-71	100.0
WP_010922083.1\|1299320_1299677_-	hypothetical protein	Q79S88	Temperate_phage	4.5e-62	100.0
WP_010922082.1\|1299676_1300009_-	hypothetical protein	Q79S86	Temperate_phage	9.6e-59	100.0
WP_011054743.1\|1299998_1300415_-	hypothetical protein	Q938K7	Temperate_phage	1.1e-56	100.0
WP_010922080.1\|1300468_1301287_-\|capsid	N4-gp56 family major capsid protein	Q79S85	Temperate_phage	4.0e-146	100.0
WP_011054744.1\|1301290_1301899_-	hypothetical protein	Q938K8	Temperate_phage	1.3e-96	100.0
WP_011054745.1\|1302030_1302297_-	hypothetical protein	Q938K9	Temperate_phage	1.5e-38	100.0
WP_002986829.1\|1302358_1302598_-	hypothetical protein	Q938L0	Temperate_phage	2.8e-36	100.0
WP_011054746.1\|1302569_1304048_-\|capsid	phage capsid protein	Q938L1	Temperate_phage	8.2e-275	100.0
1303658:1303674	attL	NA	NA	NA	NA
WP_002986832.1\|1304052_1305555_-\|portal	phage portal protein	Q938L2	Temperate_phage	5.4e-282	100.0
WP_010922074.1\|1305568_1306780_-\|terminase	PBSX family phage terminase large subunit	Q938L3	Temperate_phage	3.7e-225	99.7
WP_011054747.1\|1306862_1307336_-	hypothetical protein	Q938L4	Temperate_phage	4.3e-76	99.4
WP_002986841.1\|1307386_1307764_-	ASCH domain-containing protein	Q938L5	Temperate_phage	1.7e-67	100.0
WP_076639321.1\|1307824_1308208_-	GNAT family N-acetyltransferase	B5SP24	Lactococcus_phage	3.9e-35	58.5
WP_002986850.1\|1308216_1308894_-	hypothetical protein	Q938L6	Temperate_phage	8.7e-131	100.0
WP_002986854.1\|1308872_1309391_-	ParB N-terminal domain-containing protein	Q938L7	Temperate_phage	1.5e-90	100.0
WP_011054748.1\|1309471_1309729_+	hypothetical protein	NA	NA	NA	NA
WP_011017866.1\|1310367_1310808_-	ArpU family transcriptional regulator	Q938L8	Temperate_phage	5.0e-79	100.0
WP_011054751.1\|1311248_1311755_-	DUF1642 domain-containing protein	Q938L9	Temperate_phage	9.8e-95	100.0
WP_011054753.1\|1311918_1312323_-	hypothetical protein	Q938M1	Temperate_phage	6.0e-71	100.0
WP_011054754.1\|1312332_1312602_-	hypothetical protein	Q938M2	Temperate_phage	4.0e-47	100.0
WP_011054755.1\|1312598_1312883_-	DUF3310 domain-containing protein	Q938M3	Temperate_phage	5.4e-50	100.0
WP_011054756.1\|1312876_1313128_-	hypothetical protein	Q938M4	Temperate_phage	6.8e-41	100.0
WP_011054757.1\|1313124_1313481_-	hypothetical protein	A0A1P8VVP9	Streptococcus_phage	1.6e-51	85.6
WP_011054758.1\|1313477_1313918_-	RusA family crossover junction endodeoxyribonuclease	A0A097PAS0	Streptococcus_pyogenes_phage	8.5e-79	97.3
WP_011106686.1\|1313917_1314121_-	hypothetical protein	Q938M6	Temperate_phage	4.7e-32	100.0
WP_011054759.1\|1314126_1314546_-	single-stranded DNA-binding protein	Q938M7	Temperate_phage	1.6e-71	100.0
WP_011054760.1\|1314538_1315213_-	ERF family protein	Q938M8	Temperate_phage	2.5e-106	100.0
WP_011018142.1\|1315213_1315696_-	siphovirus Gp157 family protein	Q938M9	Temperate_phage	8.2e-51	100.0
WP_011054761.1\|1315717_1315972_-	hypothetical protein	Q938N0	Temperate_phage	7.4e-43	100.0
WP_011054762.1\|1316119_1316353_-	hypothetical protein	Q938N1	Temperate_phage	5.0e-38	100.0
WP_023079816.1\|1316333_1316723_-	DnaD domain protein	Q938N2	Temperate_phage	1.1e-58	99.2
WP_011106684.1\|1316868_1317126_-	hypothetical protein	A0A1S5SFN6	Streptococcus_phage	1.2e-11	46.4
WP_011054765.1\|1317219_1317405_-	hypothetical protein	Q938N3	Temperate_phage	1.1e-24	100.0
WP_002988339.1\|1317433_1317691_-	hypothetical protein	NA	NA	NA	NA
WP_011054766.1\|1317936_1318191_-	hypothetical protein	NA	NA	NA	NA
WP_002986887.1\|1318179_1318380_+	KTSC domain-containing protein	A0A1S5S8T9	Streptococcus_phage	6.3e-21	72.3
WP_011054767.1\|1318558_1319287_-	oxidoreductase	Q938N5	Temperate_phage	6.9e-134	100.0
WP_002986891.1\|1319297_1319489_-	hypothetical protein	A7J270	Streptococcus_phage	1.2e-24	90.5
WP_011054768.1\|1320284_1320644_+	helix-turn-helix transcriptional regulator	Q938N6	Temperate_phage	1.1e-60	100.0
WP_002986894.1\|1320657_1321038_+	hypothetical protein	Q938N7	Temperate_phage	5.3e-69	100.0
WP_002986895.1\|1321048_1321570_+	hypothetical protein	Q938N8	Temperate_phage	2.3e-67	100.0
WP_002986896.1\|1321688_1322843_+\|integrase	site-specific integrase	Q938N9	Temperate_phage	2.8e-206	100.0
1323022:1323038	attR	NA	NA	NA	NA

DBSCAN-SWA_6

1857269 : 1877103

Streptococcus_phage(56.25%)

holin,integrase

attL 1860468:1860488|attR 1874404:1874424

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011285269.1\|1857269_1858490_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	1.6e-05	23.8
WP_021340699.1\|1858500_1860483_-	DNA mismatch repair endonuclease MutL	A0A1B2LRQ5	Wolbachia_phage	1.3e-62	30.1
1860468:1860488	attL	NA	NA	NA	NA
WP_003058754.1\|1860577_1861729_-\|integrase	site-specific integrase	A0A1X9I5Y5	Streptococcus_phage	3.6e-84	44.9
WP_011185066.1\|1861977_1862121_+\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_003058809.1\|1862982_1863750_-	helix-turn-helix domain-containing protein	Q76TK4	Streptococcus_pyogenes_phage	3.6e-72	83.1
WP_002992503.1\|1863903_1864110_+	helix-turn-helix transcriptional regulator	X2KUC2	Streptococcus_phage	2.4e-07	47.0
WP_002992502.1\|1864143_1864344_+	helix-turn-helix transcriptional regulator	A0A1S5SE31	Streptococcus_phage	3.4e-11	56.7
WP_002992501.1\|1864364_1864772_+	hypothetical protein	A0A1X9I5V7	Streptococcus_phage	1.3e-49	69.4
WP_011185071.1\|1865183_1865711_+	hypothetical protein	R9QNB1	Lactococcus_phage	9.7e-21	40.2
WP_011285273.1\|1865937_1866132_+	hypothetical protein	NA	NA	NA	NA
WP_000916926.1\|1866272_1866725_+	hypothetical protein	NA	NA	NA	NA
WP_011285276.1\|1866826_1867159_+	hypothetical protein	NA	NA	NA	NA
WP_021340709.1\|1867158_1867350_+	hypothetical protein	NA	NA	NA	NA
WP_003058810.1\|1867361_1867691_+	hypothetical protein	NA	NA	NA	NA
WP_010922766.1\|1867693_1867966_+	hypothetical protein	A0A1X9I5U9	Streptococcus_phage	3.6e-19	60.0
WP_011285278.1\|1867966_1868833_+	hypothetical protein	A0A1X9I6L2	Streptococcus_phage	6.1e-121	73.8
WP_011285279.1\|1868844_1870239_+	phage protein	A0A1W6JQD6	Staphylococcus_phage	1.3e-48	38.1
WP_011285280.1\|1870532_1870787_+	hypothetical protein	NA	NA	NA	NA
WP_011285281.1\|1870783_1870957_+	hypothetical protein	A0A1X9I5U0	Streptococcus_phage	8.6e-11	59.6
WP_011285283.1\|1871137_1871647_+	hypothetical protein	A0A1X9I5U4	Streptococcus_phage	1.9e-29	63.5
WP_002992480.1\|1871720_1872209_+	hypothetical protein	A0A1X9I5V2	Streptococcus_phage	1.4e-45	54.9
WP_011285284.1\|1872612_1872975_+	DUF1492 domain-containing protein	NA	NA	NA	NA
WP_011285285.1\|1872949_1873333_+	ArpU family transcriptional regulator	Q938L8	Temperate_phage	3.7e-14	41.7
WP_011285286.1\|1873497_1874151_+	hypothetical protein	NA	NA	NA	NA
WP_011285287.1\|1874547_1877103_-	DNA mismatch repair protein MutS	A0A1V0SGG8	Hokovirus	6.8e-43	22.8
1874404:1874424	attR	NA	NA	NA	NA

DBSCAN-SWA_7

1903513 : 1913495

Streptococcus_phage(75.0%)

integrase

attL 1903087:1903101|attR 1910649:1910663

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1903087:1903101	attL	NA	NA	NA	NA
WP_000694580.1\|1903513_1903687_-	hypothetical protein	A0A1X9I5U0	Streptococcus_phage	1.9e-10	59.6
WP_011285313.1\|1903973_1905587_-	hypothetical protein	A0A1P8BMF9	Lactococcus_phage	2.4e-147	53.1
WP_011285314.1\|1905576_1906098_-	hypothetical protein	NA	NA	NA	NA
WP_011285315.1\|1906107_1906476_-	hypothetical protein	A0A1X9I6M4	Streptococcus_phage	2.6e-12	47.1
WP_021340713.1\|1906384_1906576_-	hypothetical protein	NA	NA	NA	NA
WP_011285317.1\|1906575_1906908_-	hypothetical protein	NA	NA	NA	NA
WP_011285318.1\|1906919_1907102_-	hypothetical protein	NA	NA	NA	NA
WP_014407970.1\|1907322_1907565_-	hypothetical protein	NA	NA	NA	NA
WP_011285320.1\|1907621_1908188_-	hypothetical protein	A0A0A7S0G2	Clostridium_phage	5.0e-23	42.9
WP_011285321.1\|1908203_1908392_-	helix-turn-helix transcriptional regulator	A0A1X9I5U7	Streptococcus_phage	1.7e-12	59.7
WP_011285322.1\|1908560_1909004_+	helix-turn-helix transcriptional regulator	A0A1X9I723	Streptococcus_phage	1.8e-07	48.6
WP_011285323.1\|1909183_1910347_+\|integrase	site-specific integrase	A0A1X9I6A9	Streptococcus_phage	2.8e-161	70.5
WP_002982092.1\|1910503_1911115_-	30S ribosomal protein S4	NA	NA	NA	NA
1910649:1910663	attR	NA	NA	NA	NA
WP_002991405.1\|1911844_1912117_-	hypothetical protein	NA	NA	NA	NA
WP_002991408.1\|1912133_1913495_-	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	1.0e-154	63.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP011068

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection