CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP012324	Bifidobacterium breve DSM 20213 = JCM 1192	4 crisprs	cas3,WYL,c2c9_V-U4	1	1	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP012324_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP012324_1

1342450-1342563

Orphan

Consensus_repeat	Method
CAGCCCTGCGAGATTTGCAGTGCTGGG	PILER-CR
CAGCCCTGCGAGATTTGCAGTGCTGGG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_AP012324_1

>merge|NZ_AP012324|1|1342450-1342563|PILER-CR,CRISPRCasFinder
CAGCCCTGCGAGATTTGCAGTGCTGGGGGTGCAGCTCTCGCAGTGCTGGAGGTGCGAGATTTGCAGTGCCGGTTCCGGGTCGTTTTCCAGCCCTGCGAGATTTGCAGTGCTGGG

>NZ_AP012324|1|1|1342450-1342563|PILER-CR
CAGCCCTGCGAGATTTGCAGTGCTGGG	GGTGCAGCTCTCGCAGTGCTGGAGG
TGCGAGATTTGCAGTGCCGGTTCCGGG	TCGTTTTCCAGCCCTGCG
AGATTTGCAGTGCTGGG

>NZ_AP012324|1|1|1342450-1342522|CRISPRCasFinder
CAGCCCTGCGAGATTTGCAGTGCTGGG	GGTGCAGCTCTCGCAGTGC
TGGAGGTGCGAGATTTGCAGTGCCGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP012324.1\|WP_003830686.1\|1343012_1343168_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_003830689.1\|1341635_1341890_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_003830698.1\|1331313_1332159_-\|type-IV-secretion-system-protein	unknown	unknown	gnl\|CDD\|377390
NZ_AP012324.1\|WP_032738358.1\|1345483_1346017_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223725
NZ_AP012324.1\|WP_003830669.1\|1350635_1351898_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366747
NZ_AP012324.1\|WP_019727506.1\|1340363_1341029_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|349760
NZ_AP012324.1\|WP_003830683.1\|1344237_1344606_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_003830675.1\|1349011_1349305_-\|DUF4193-domain-containing-protein	unknown	unknown	gnl\|CDD\|379391
NZ_AP012324.1\|WP_003830692.1\|1340085_1340358_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_003830696.1\|1332770_1338140_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|374503
NZ_AP012324.1\|WP_025341798.1\|1346117_1348442_-\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NZ_AP012324.1\|WP_003830671.1\|1349456_1350530_+\|DUF3071-domain-containing-protein	unknown	unknown	gnl\|CDD\|378619
NZ_AP012324.1\|WP_003830693.1\|1339584_1340058_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_AP012324.1\|WP_003830690.1\|1341141_1341639_-\|WhiB-family-transcriptional-regulator	unknown	unknown	unknown
NZ_AP012324.1\|WP_003830699.1\|1330931_1331282_-\|PrgI-family-protein	unknown	unknown	gnl\|CDD\|378907
NZ_AP012324.1\|WP_019727505.1\|1343527_1344241_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_003817136.1\|1332173_1332407_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_003830682.1\|1344605_1344872_-\|toxin-antitoxin-system-antitoxin-component-Xre-family	unknown	unknown	gnl\|CDD\|285830
NZ_AP012324.1\|WP_032738360.1\|1338491_1339481_-\|FIVAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|369422
NZ_AP012324.1\|WP_003830677.1\|1348535_1349012_-\|dUTP-diphosphatase	unknown	unknown	gnl\|CDD\|234802

Protein	Function_ID	Function_description	E-value
NZ_AP012324.1\|WP_003830698.1\|1331313_1332159_-\|type-IV-secretion-system-protein	gnl\|CDD\|377390	pfam04610, TrbL, TrbL/VirB6 plasmid conjugal transfer protein.	0.00102229
NZ_AP012324.1\|WP_003830669.1\|1350635_1351898_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|366747	pfam01663, Phosphodiest, Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.	1.12498e-26
NZ_AP012324.1\|WP_019727506.1\|1340363_1341029_-\|ParA-family-protein	gnl\|CDD\|349760	cd02042, ParAB_family, partition proteins ParAB family. ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.	1.68238e-20
NZ_AP012324.1\|WP_003830675.1\|1349011_1349305_-\|DUF4193-domain-containing-protein	gnl\|CDD\|379391	pfam13834, DUF4193, Domain of unknown function (DUF4193). This domain of unknown function contains four conserved cysteines and a conserved histidine, including a CXXXXH motif.	2.24253e-40
NZ_AP012324.1\|WP_025341798.1\|1346117_1348442_-\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NZ_AP012324.1\|WP_003830696.1\|1332770_1338140_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|374503	pfam16364, Antigen_C, Cell surface antigen C-terminus. This repeated domain is found at the C-terminus of cell surface antigens. In the Streptococcus mutans antigen I/II there are three repeats of this domain, a cleft between the first two of these forms a binding site for the human salivary agglutinin (SAG).	2.37054e-75
NZ_AP012324.1\|WP_003830693.1\|1339584_1340058_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	3.88284e-08
NZ_AP012324.1\|WP_032738358.1\|1345483_1346017_+\|peptidylprolyl-isomerase	gnl\|CDD\|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	1.31129e-60
NZ_AP012324.1\|WP_003830671.1\|1349456_1350530_+\|DUF3071-domain-containing-protein	gnl\|CDD\|378619	pfam11268, DUF3071, Protein of unknown function (DUF3071). Some members in this family of proteins are annotated as DNA-binding proteins however this cannot be confirmed. Currently no function is known.	9.58611e-47
NZ_AP012324.1\|WP_003830699.1\|1330931_1331282_-\|PrgI-family-protein	gnl\|CDD\|378907	pfam12666, PrgI, PrgI family protein. This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 116 and 146 amino acids in length. This protein is found in an operon that is part of a Type IV secretion system.	8.47971e-20
NZ_AP012324.1\|WP_003830682.1\|1344605_1344872_-\|toxin-antitoxin-system-antitoxin-component-Xre-family	gnl\|CDD\|285830	pfam08667, BetR, BetR domain. This family includes an N-terminal helix-turn-helix domain.	2.19898e-06
NZ_AP012324.1\|WP_032738360.1\|1338491_1339481_-\|FIVAR-domain-containing-protein	gnl\|CDD\|369422	pfam07554, FIVAR, FIVAR domain. This domain is found in a wide variety of contexts, but mostly occurring in cell wall associated proteins. A lack of conserved catalytic residues suggests that it is a binding domain. From context, possible substrates are hyaluronate or fibronectin (personal obs: C Yeats). This is further evidenced by. Possibly the exact substrate is N-acetyl glucosamine. Finding it in the same protein as pfam05089 further supports this proposal. It is found in the C-terminal part of Bacillus sp. Gellan lyase, which is removed during maturation. Some of the proteins it is found in are involved in methicillin resistance. The name FIVAR derives from Found In Various Architectures.	0.00243872
NZ_AP012324.1\|WP_003830677.1\|1348535_1349012_-\|dUTP-diphosphatase	gnl\|CDD\|234802	PRK00601, dut, dUTP diphosphatase.	1.50553e-64

>NZ_AP012324.1|WP_003830689.1|1341635_1341890_-|hypothetical-protein
MITRIDCSEAGFSEFLLANPQLDGHGDLIWQLHAVYWRNKRLGHPKAVGLLIQYARAWAARNPGETAIGRLQARKTPMTQGRRP
>NZ_AP012324.1|WP_003830690.1|1341141_1341639_-|WhiB-family-transcriptional-regulator
MNGRDMMPACARIAAVDPAMADRMWNTTTDDDGRDLVDERMRGKGRVLCAACPMRLDCISRALVNGWKDKAVYGGLDYASRWTLARLIARDLHIADGGLHRIPRSRVRDWLAEHPDWGERMRRDGRDYWRRTKRRQRSRREYTHDDPLSLPTEPVPKGLVQGSLF
>NZ_AP012324.1|WP_019727506.1|1340363_1341029_-|ParA-family-protein
MNDKKNREPMVIALATGKGGSMKTTSAVFLACALVDQSRGEQHVLVADADVQGDAKDWWYRAAELGDPLPFDVMSAAPADITHLHGINDRLDDPVDWVLIDSAPYGRALDESVNNADLVVIPSSPSRIDLDQAVGVKDLCDRRGVPAAILLCRTEANTTALRDALAWIDDAGIACFETLIPKRQDILNAKSTRPRGSRLHEYRDLAAELKRTMRQLKGEDL
>NZ_AP012324.1|WP_003830692.1|1340085_1340358_-|hypothetical-protein
MNLTPRPRDLTMLLTGGRPAPADTGKPESVETEIPKNRKTVKPSDAEGWVKTSVSLRASTRRRLKTWAAEHDMRIQEVVDAALETYLGLK
>NZ_AP012324.1|WP_003830693.1|1339584_1340058_-|WhiB-family-transcriptional-regulator
MFLKGECADFPGSWSDRMWGPDDLPNQRSQYDLRRAAVRICEACPVRAECLAFGIMVRDQYGIYGGLPLRARRQVLKTAQEAGFRFDPDDPTAARRLARYIRENPEIVAAAREKECKRRKTEQRNARQQRWRAATRSTGKAKAPAAATQEPMQDTLF
>NZ_AP012324.1|WP_032738360.1|1338491_1339481_-|FIVAR-domain-containing-protein
MEPVETPAENITEPSKDGRKCPKWLPPLVAAVCAVILVAAGVVGWNAYSGAKLAEAKEACAAADTVRSNANEYNALLNGDAADAAAVRAEQVKDSKTVESLGKELKAMAPEYEGCVAEDAQGLDAATVKLNEQADWYGTHEKSLSKAVRAVTESKAAKTLETAKTNLTAKLDEASKLLADSDGKVADNATRDALSNAIDAANGLKDGNDPAKIDGARKTVEDAINGVNASVQAKTDADAQAAAAAAQAQAQARSAYNGGSSYSGGAYRRTEGSASGSNTYRGTTSGGTGSGSTSGSGPAGGSAPKPNLSGGHGCGNSCPPPSSDGLIHH
>NZ_AP012324.1|WP_003830696.1|1332770_1338140_-|LPXTG-cell-wall-anchor-domain-containing-protein
MMKAGVAAVAAIATLGAGGVVASTAFAGGGGGNQPGAGGNMDVLQFWQYKDDASGAWGPATSLDSVRTAMNNAGVALQGGGVTKAQAALDQARTECETGFRQRHPGEGDGDCRVVAVGAVPYISGRSFIYDGTGYYSPSLPGGWYDNWNTYVAPNTYNYAGTQSYRTSDGFSDDPSNSVDAIMRRNVGASSKPSIVVIVLDKYQPAPPNYDLTVSTQAGGTFTQAGATGDVSDAITTSRGNSSISENVTGTITLHWTGLDGTTRTASKQFTQDNNTTQNVSFGFRDVDKTWKSWPAGSYYYDVNVPKQGKMKADAGHAGAADARESWKPVPTPPSKKLTNAAGQQVTSDAQQIAPGSLYTAHIAAQSNASEHFWLYDTIDVTAQKVLIGGTDRDDVSKVTVTDQDGNAVKADITVDDSQPGKRIVKAHVLNPASGQYTLNVPQSATPTGSDYTIPDDSQACWTGDEYGSTDKSHCQTGNSEQVGKVTPKPDKVWVLDSNGALNAEDPEHTNDKGSDNRTFVTGDAIGAVVNGRIPAHLLNPFTSYSITDDWTASAQWIDWNHKDQVRVYVDGKDVTDQFDITIDTAKHTTTATAKQSFLTKTAFGTADRKVKLYIGGIVRQVPNAQAAADQKKLTNKATETWNNESRPTNEPPVWVRNPKPDKVWSADQGQAANAEDSAWANNVNADTHTFVQQDDFGVTVNGLLPRNLARKMSSYELGDDFSKSARNIDLDSATVTVTIDGKDAKNLFDVHKQDDRVWVSAKQELLDTTYNQAADRKVRMTIKGTFLKDVLKAGQKVQLTNGDWEKWNQQTVPGNEPPVKEWSPNPDKSWIRLGEDGKWAAVVDPTGSNKTGADTLKFLDGDQVASVVNGVIASDLVKVTDIKLTDDYATADYIWDLASDQSQIRVYEADATTDAASSVADIANKGRDVTDQFDITVAGTKVTATAKPEYRAAQAGLKNPKQISLLLPGVVNFANGKGAAQVRKDFGKNAGDELTFCENPDGSKLTNKGSEKVNHESQPTNEPYICGYVPPVVKKVVAEGSQGGANNDANDKVVYPGQKVEYRLTTRPQIPSDLAYRIVSIRDTDTYDRYLEPDQQTLEVTDLATGDQLTTSDPQMGVEGDYTVAWDNANHQFTITYSDKYVAEHWRAGSHPQVQVRFEGTVAKDAPTDRRVDNQWMLTLNNSITPSNIVDNLPPKHDPSKKDNQSKEQGDPSVSIDGKTMLLGDTGNYVVTLDLKQTNNAYRVWKAGITDDFDDEHLAIDGTKIEVLDSKGQDVTGKFNIQIKDGVAYVYAKTVDTWIPKKGVTVKGDPQPTDLAAYASSSKHDPLSDPSIDQNLLGQEYRIVMPYKVVKVEDGYTVRNKAIQVTNDLTRETNEVSNPLKEINPAKDVTVKVGGESIDGRSVYKDRTFLYLFDSSIIPAGRAYPRVDQWRIVDPLNTEYDQYTGQWAVYASRDLYRDGKVIAAKGDKLAGSGFDSSKFGGDLFDAAADANGVVTVEATEAYRTLVSADNSHENGWRAYIQCKRLKVSDRVENRFTEYFNDKELESNIVWTRTPDMTPSIHIEKYDVASGEQAGDRDDVKDALKMAGDSQQIAFKITNTSKTDSSTGEGAWYLAKDLKMVDRTIAGEGDVTDLKYPDNWDTLVLKPGESTIITGTLKGVEQGGKHTDRVKVTGTPLVECPVTDQFGGQQSTDGNQTGDTKVDGDASDTTGLKQVKVGDRTLCEDTTVESNTDDWNGYRAKPLASTGTAVLGLAGGALAVLLAGGSLLVFRKRHCAQGSGRHTAVNAGK
>NZ_AP012324.1|WP_003817136.1|1332173_1332407_-|hypothetical-protein
MYGITIAADSGSVVTSALQLFSQFAIIGGGLWAVWGVVTLAGGLKDQNGPATQSGVWQVVGGGLIIAAAALFSNIAL
>NZ_AP012324.1|WP_003830698.1|1331313_1332159_-|type-IV-secretion-system-protein
MVDFIVGILNSIGSGVGDDLVADLLKTPAEYNAGMYQLSLTVARSAVKPIASTILAIMCVLELARVSTRADGDRELGVKLVAMAMFKLTLVFTAAQHSELMLQAIDEIGDSVLGGIHSAAPTTGASSGLGLGDSMRDAIDSAGWMGQIPCLILLLIPFLVSKGATIVVTVVILLRFVQIYMLTAFNPLPIAFIAQEETRQWGINYFKQYASLVFQCATLYLAILMYRTLVGGTLNPSKFKDGDSLSGWVMDNFTGLLLASVMLIGIVMAANSVAKKLFGGE
>NZ_AP012324.1|WP_003830699.1|1330931_1331282_-|PrgI-family-protein
MALQMPVYRELTTIESKVFMGMSWRQCLAAVILAIVCGGGYVGLWLGLGMDPNLAMYLIFPPGLPIAVWGWVRPKGLMPEKYLKYILRHYTQREVYLLDGPGRPYRTGVKPTIKER
>NZ_AP012324.1|WP_003830686.1|1343012_1343168_-|hypothetical-protein
MNWLAIVLIVFVAFSWLMTLALCRAARLGDEMAARLADERRAAQQREEERP
>NZ_AP012324.1|WP_019727505.1|1343527_1344241_-|hypothetical-protein
MSNEMSCDSVARRVNGENPLDVLVSVSTPYGPLLTDDYGRSIRFAEYGDGPCRFGDRPIQVMKPYEWLADRVYVFDDEAVAPFKDDVARFVVEACRCFVGGDGDHDRSVVLCREGVAEQLDLSSDAFAPMVGSDGNAVSFSYQPCDRLRCVCSTNPQKGLGVFHVWTERGTTYQAVLGPCAYERRPEKALTLPDELWSRNESWMRDFFEQETSDFLCLGVVSRRTNIRFVEGGGAMV
>NZ_AP012324.1|WP_003830683.1|1344237_1344606_-|hypothetical-protein
MAGGIYEQSEWPDSRWDCVTVCDGCHTMVWSTFWDDYDSAARDAYFARNGWRNYCVPGDTEILELCPACAVRALRRGETRGLADSWLRPTHVYTHAFREVDAQLSARERMVAGLLLTEGRAS
>NZ_AP012324.1|WP_003830682.1|1344605_1344872_-|toxin-antitoxin-system-antitoxin-component-Xre-family
MLKYSKNEPSQEERTMNVVTQRISALVKDEGLTCAQLGSLLGLSKTSANGKLLGRIGWTTSDIVVLSEHFHVSTDYLLGFDADHEEVA
>NZ_AP012324.1|WP_032738358.1|1345483_1346017_+|peptidylprolyl-isomerase
MTTVIMRTSEGDITIDLFDDKAPNTVANFLGLATGEKEWADPYTGQPSHGKFYNGLTFHRIIKQFMIQGGCPLGTGGPGYEFDDEIDPSLKFDKPYLLAMANAGLRRGMDGKVHGTNGSQFFITTVPTPWLDGHHTIFGEVADDASKKVVDKLEAVETDPMDRPLEPAVILSVDVAE
>NZ_AP012324.1|WP_025341798.1|1346117_1348442_-|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MSEIDGEQYAARKLGCEISADPLNPLEPIKQVCKAHHPGEDLSILDRAYRRAVIQHSAQRRKSGEPYIIHPLAVSQILADLGMGPIVVAAGLLHDTVEDTDYTLDQCRAEFGDTVAGLVDGVTKLSQLEVGDSAQAETIRKLVVAMSRDVRTLVVKLADRVHNARTWRYVKTTSAQKKARETLDVYAPLANRLGMNAIKTELEELSFKVLYPKIYNEIVVLVARRAGQRDVYLKQILAEINEDLDEQNIKAYVTGRPKDYFSIYQKMIVRGHDFANIYDLVGVRIIVDTIQDCYAALGAVHARWNPVPGRFKDYIAMPKLNMYQSLHTTVVGPGGKPVEIQIRTWDMHRRAEFGIAAHWKYKENGQAGRALSSPDKSDRKRDVNNQELSEADNLKWIQQLADWTSETPDSNEFLGSLKEDLGSSEVYVFTPKGKIVSLPAHATPVDFAYAVHTEVGHRTMGARVNGRLVPLDTTLDNGDTVEILTSKSDTAGPSRDWLSFVKSPKARNKIRQWFSKERRTEAIEEGRDELTRAMRKRNLPVNALLTTEALIGVADDLNFPNADAVFAAIGDGQISTQNVISHLVKDAGADEVDEEVEQEALPLKPVERKSSSSSTGVSVKGVGDVWVKLARCCMPVPGDQIIGFITRNQGVSVHRTDCQNMIDLKNKQPERVVEVEWTSTKGLFMVKIQVEALDRRNLLSDVTRVLSDHGVNIISGTIATGSDRVATSQFSFEMADPQHLNTLLAAVRKIDGVFDVYRLTGAKESAEPRMRKMK
>NZ_AP012324.1|WP_003830677.1|1348535_1349012_-|dUTP-diphosphatase
MAFDETYNEPESTEVLVKSLDPEHPARLHYAHAGDAGADLITTVDVTLKPFERALVPTGVAIALPAGYVALVHPRSGLASKQGVTVLNAPGTVDAGYRGEIKVPLINLDPEHTAVFHPGDRIAQMVIQRYVEARFIPAETLPGSDRAERGFGSTGVAS
>NZ_AP012324.1|WP_003830675.1|1349011_1349305_-|DUF4193-domain-containing-protein
MAQDYDSPRNKDEDEESLQALGKSAQNTSSDIDDDENAIAEDYELPGADLSNEDSSVTVIPMQGDEFICSQCFLVKHRSQLAYTDEDGQPVCEECAA
>NZ_AP012324.1|WP_003830671.1|1349456_1350530_+|DUF3071-domain-containing-protein
MPKDRLEKARFERVSETGDLVFSLGGRQFAVSLDDTLERAILEAKQIRSEQQQPEQPHEQSTLPISQIQSLIRAGADPSRVAERYGLSTTLVRRFSAAVETEKQYAIEQFLTVPAPKDSKVRTINELVERTLAAASIGMESVTWKSTRRGLEPWHIVAIFTSAGREIHAEWTWNMHDNSVVCLNNAARKLLGEQNPRTENAGGAKASPEPALPGDSVRSARIERAVSAWAAPKPSAPQTRPASSNPVTSTGSMPPIDLSASGSMPPVKLSAPVSTGAASTQTPPDDGRIPAAQSDAPIHDEVTSDSGAAPVETGKAAKKEQTAAPAKAAPAEPAAKPSRRKSGRSAVPSWDEILFGD
>NZ_AP012324.1|WP_003830669.1|1350635_1351898_-|alkaline-phosphatase-family-protein
MSVETPDMDELLRLVPTVTYGDTAAGRGGALHLSAVLPALSAAIGHPISTKVHADPQACKKALGLPDATSAIVVLVDGLGYWNLAMRLGHAPYLRSLMNESANQRPIATCAPSTTVAAMATFGTGTCPGLTGMAGYTQLEPNNHKLIQLIQFKDALAPKPVNPRITTPPMVDPHDLQREQTVFEKLRRQEVRVTSSGLPKFAGSPLTEAALRGTDYQANVTPRDRVLAAARAARRPGLTYLYIRDADKVGHNYGWDSEHWVAAFEHIDAQLALLKRSASAGTLIVIIADHGMVQTDMDQRLDIATEPSLIHGVELVGGEPRSLMLYAEPGESPDAIADRWRDRLGDAALVRTKEQACADGLFGPVSERIRPILGDVMVQAAGAATFVDSRTQGDKATHLPSVHGSQTMMEMDIPCLIDVA

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Crispr_ID: NZ_AP012324_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP012324_2

2008985-2009131

Orphan

Consensus_repeat	Method
AATCTCCTAAAATCCTGTCACTAAG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_AP012324_2

>merge|NZ_AP012324|2|2008985-2009131|CRISPRCasFinder
TTCGTCCTAAAATTCTGTCACTGAGTCAAAGCCAATGACAGATATTTAGGAAACCAACCCCAATCTCCTAAAATCCTGTCACTAAGACTCACTTAGCGACAGTAATTTAGGACGACTGGGATAATCTCCTAAAATCCTGTCGCTAAG

>NZ_AP012324|2|2|2008985-2009131|CRISPRCasFinder
TTCGTCCTAAAATTCTGTCACTGAG	TCAAAGCCAATGACAGATATTTAGGAAACCAACCCC
AATCTCCTAAAATCCTGTCACTAAG	ACTCACTTAGCGACAGTAATTTAGGACGACTGGGAT
AATCTCCTAAAATCCTGTCGCTAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP012324.1\|WP_025300055.1\|2000063_2001932_-\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|227111
NZ_AP012324.1\|WP_003829786.1\|2007489_2008182_-\|50S-ribosomal-protein-L1	unknown	unknown	gnl\|CDD\|180071
NZ_AP012324.1\|WP_032738290.1\|2018442_2021538_-\|Rne/Rng-family-ribonuclease	unknown	unknown	gnl\|CDD\|273254
NZ_AP012324.1\|WP_003829789.1\|2003044_2003932_-\|biotin--[acetyl-CoA-carboxylase]-ligase	unknown	unknown	gnl\|CDD\|223417
NZ_AP012324.1\|WP_003829794.1\|1998448_2000071_-\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|227136
NZ_AP012324.1\|WP_003829782.1\|2010554_2011382_-\|transcription-termination/antitermination-factor-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_AP012324.1\|WP_003829785.1\|2008197_2008629_-\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
NZ_AP012324.1\|WP_021649514.1\|2006359_2007217_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225306
NZ_AP012324.1\|WP_032738293.1\|2004175_2006281_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_003829781.1\|2011414_2011642_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|236066
NZ_AP012324.1\|WP_003829776.1\|2017673_2017925_-\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NZ_AP012324.1\|WP_080543816.1\|1987679_1988054_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223508
NZ_AP012324.1\|WP_015439254.1\|2014676_2015810_-\|glutamate-5-kinase	unknown	unknown	gnl\|CDD\|235460
NZ_AP012324.1\|WP_003829777.1\|2015915_2017607_-\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237045
NZ_AP012324.1\|WP_003829795.1\|1988926_1998409_-\|type-I-polyketide-synthase	unknown	unknown	gnl\|CDD\|227315
NZ_AP012324.1\|WP_032738292.1\|2011971_2013177_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NZ_AP012324.1\|WP_014484324.1\|2017947_2018256_-\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NZ_AP012324.1\|WP_003829783.1\|2009245_2010199_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_003829790.1\|2002443_2003043_+\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|376871
NZ_AP012324.1\|WP_032738291.1\|2013318_2014581_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213024

Protein	Function_ID	Function_description	E-value
NZ_AP012324.1\|WP_025300055.1\|2000063_2001932_-\|ATP-grasp-domain-containing-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_AP012324.1\|WP_003829786.1\|2007489_2008182_-\|50S-ribosomal-protein-L1	gnl\|CDD\|180071	PRK05424, rplA, 50S ribosomal protein L1; Validated.	1.72993e-143
NZ_AP012324.1\|WP_032738290.1\|2018442_2021538_-\|Rne/Rng-family-ribonuclease	gnl\|CDD\|273254	TIGR00757, Ribonuclease_E/G-like_protein, ribonuclease, Rne/Rng family. This model describes ribonuclease G (formerly CafA, cytoplasmic axial filament protein A), the N-terminal domain of ribonuclease E in which ribonuclease activity resides, and related proteins. In E. coli, both RNase E and RNase G have been shown to play a role in the maturation of the 5' end of 16S RNA. The C-terminal half of RNase E (excluded from the seed alignment for this model) lacks ribonuclease activity but participates in mRNA degradation by organizing the degradosome. [Transcription, Degradation of RNA].	1.38642e-152
NZ_AP012324.1\|WP_003829789.1\|2003044_2003932_-\|biotin--[acetyl-CoA-carboxylase]-ligase	gnl\|CDD\|223417	COG0340, BirA, Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism].	9.24621e-32
NZ_AP012324.1\|WP_003829794.1\|1998448_2000071_-\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NZ_AP012324.1\|WP_003829782.1\|2010554_2011382_-\|transcription-termination/antitermination-factor-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	3.58026e-66
NZ_AP012324.1\|WP_003829785.1\|2008197_2008629_-\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	8.69761e-91
NZ_AP012324.1\|WP_021649514.1\|2006359_2007217_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	1.21655e-16
NZ_AP012324.1\|WP_003829781.1\|2011414_2011642_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|236066	PRK07597, secE, preprotein translocase subunit SecE; Reviewed.	3.68916e-12
NZ_AP012324.1\|WP_003829776.1\|2017673_2017925_-\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	5.68869e-49
NZ_AP012324.1\|WP_080543816.1\|1987679_1988054_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223508	COG0431, COG0431, Predicted flavoprotein [General function prediction only].	1.33777e-15
NZ_AP012324.1\|WP_015439254.1\|2014676_2015810_-\|glutamate-5-kinase	gnl\|CDD\|235460	PRK05429, PRK05429, gamma-glutamyl kinase; Provisional.	1.3328e-175
NZ_AP012324.1\|WP_003829777.1\|2015915_2017607_-\|GTPase-ObgE	gnl\|CDD\|237045	PRK12296, obgE, GTPase CgtA; Reviewed.	0
NZ_AP012324.1\|WP_003829795.1\|1988926_1998409_-\|type-I-polyketide-synthase	gnl\|CDD\|227315	COG4982, COG4982, 3-oxoacyl-[acyl-carrier protein].	0
NZ_AP012324.1\|WP_032738292.1\|2011971_2013177_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0
NZ_AP012324.1\|WP_014484324.1\|2017947_2018256_-\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	4.17736e-35
NZ_AP012324.1\|WP_003829790.1\|2002443_2003043_+\|biotin-transporter-BioY	gnl\|CDD\|376871	pfam02632, BioY, BioY family. A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin. BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes.	6.07077e-28
NZ_AP012324.1\|WP_032738291.1\|2013318_2014581_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213024	cd10966, CE4_yadE_5s, Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins. This family contains an uncharacterized protein yadE from Escherichia coli and its bacterial homologs. Although its molecular function remains unknown, yadE shows high sequence similarity with the catalytic NodB homology domain of outer membrane lipoprotein PgaB and the surface-attached protein intercellular adhesion protein IcaB. Both PgaB and IcaB are essential in bacterial biofilm formation.	1.49426e-61

>NZ_AP012324.1|WP_003829785.1|2008197_2008629_-|50S-ribosomal-protein-L11
MAPKKKVSALIKLQIQAGKANPAPPLGPALGSHGVNIMDFCKAYNAQTQDKMGQVIPVEITVYEDRSFTFVLKTPPAAALLKKAAGIEKGTENPLTHKVGSVTKAQVREIAETKMEDLSARDIEAGMKIIEGTARSMGITVTD
>NZ_AP012324.1|WP_003829786.1|2007489_2008182_-|50S-ribosomal-protein-L1
MVKRSKKYREAAERVDRNNLYTANEAIALLKSMPSYNFDQTVEAVFRLSVDPRKADQLVRGTVNLPHGTGKTAKVLVFARGPKATEATEAGADIVGDDDLIAKVQGGFLDFDAVVATPDMMGKVGRLGRVLGPRGLMPNPKTGTVTMDVTKAVKDIKGGKIEFRVDKNGNLSFLIGKMSFDESALDENFKAVADEVKRLKPSTVKGRYLTKATITSTMNPGVPVDPNTLA
>NZ_AP012324.1|WP_021649514.1|2006359_2007217_+|helix-turn-helix-domain-containing-protein
MSDFLELLAADAANSSDFTDRSGISATDRARTVLFECLFNHLADDRVASLFTILGFEHDFTCYAIAGYPARSAARSRVDIEKIVADFGGTCLTAERPITGLTGADNGTGRTAVVALIRPVGAATPEIICNTIAPAFDADRPIALGPQRTGAEGAMRSVQATLYCLKAAPALAATAQSLPRPLRTDDALPERALIGDEDARDELIRVVYGSLTAAGPDDPTLLTVSTFLKYGGSLETCAKELNVHPNTIRYRLKRAAESTGWDATDPREAYVLITAIALGRMATAQ
>NZ_AP012324.1|WP_032738293.1|2004175_2006281_+|hypothetical-protein
MTSPASSLPAAAAHPRLARVGAAARWTLAVLACLWLALCTAVGPLYWDFENGTIANWNWTNTAFFVLSFAIYLGLIVIMVRFAAGQRVLPRAISGRLSRAGQQHSNQDLKPSQSQSVVADSNVSKRHATAASRFATLGRWITRGTNRFWKLALVFFIGWLWVPTTLLSAFGADIRSQIREFSWAWNQWTGLQQPYIGFFSFVPMDIYPTAHYMWPPDSTYLTDQHNVVLTVFYGAVAAFSRYLTGSNDAGIVALAAGQMLLAVFCCAATANRFLNRPWMGVAQSTKDKNGSSTSTGSVSSTTSARIAQDSAPQLAGGRARFLILVFFLCCPLAVFATISITKSPLFAFSFVWWFGIWYELTQTWKPAGKRKGLTATAPIRLPRHSFVAFVLSTAVMLISAKYAWYIIALQIVLALIADRRRWTTYVVALLIPTMLIHGGISLAISSGAIIGGDPIESRGVQLQMIARVASRNPEGISEEAKKNLSDVFNLDQMADAYSQQDADPVKSSGIQAKKVSYKWRTVTPEDMTNFNKAWFEIVKDNPVIALDALLAKCFGYFNVTDQPYVSMDYYVTSDYVQKNSTWIKSYNHNWRERITGFTRSWGKIPVIGWITHGNFYVVMTLLIGAAEVIRRRWLTLMTHIPLLLLMGVMITAPANNFERHMLPVAFVFGFVVLTYWRESLAERRIARQAQSSASTTTTLPQ
>NZ_AP012324.1|WP_003829789.1|2003044_2003932_-|biotin--[acetyl-CoA-carboxylase]-ligase
MMIALQAATPQLPRTKAVADQVVAVGETDSTNALAARMIGDGSLTLPECKGGTLAVGVVVTDWQSAGRGRNGHTWISQPGRCSTMSYAVRIPRAIATDESVNGWLQMIAGLVTLDALNGMIKEYGAAPNKQDCFLELKWPNDVFCHGLKLGGLLSELVLLPDGEADDDVVVVFGVGLNLALGASRLPTPQSTSLQLHVSGLPSFNEMRDAVAEREVEGFRERLAAFIADPHGQAEALREEMKAVCWARGRQVEAHFTDGTTLIGEAIGLNEDASLILRTEDGTDHTVRTADVGVL
>NZ_AP012324.1|WP_003829790.1|2002443_2003043_+|biotin-transporter-BioY
MQTSHTTSSTAATASLGRRIVAASWKPALFAVLMWLSAAAGAIPIPGTPVPITLQTFVVMLAGLMLPWRQAGSAVAAYLAAGAVGLPVFAGGASTMALVGPSAGFLFGFLPGVIVIALLRGKANTSSASAAALTAGRYLLTALVGGVVVVYALGFVIQSALTGVPIAAVALASMGFVAGDAIKAVVASLAAAGLSKLGR
>NZ_AP012324.1|WP_025300055.1|2000063_2001932_-|ATP-grasp-domain-containing-protein
MAHIVKKLLIANRGEIALRVVRTAKEMGISTVAVYSEQDRNSRYVDMADEAYLLSGDTYKDTYLNEDLLIDILHKTGADAVHPGYGFLSEVPSFAQKVEDAGAIWVGPHHTALVDLGDKITARRVALRAKVPPVPGLSEPVTDVRTLLDFAHTHGYPIMMKRTDGGGGHGITVVHDDEELRRFYMNHDALQGGDLKEYFIEKFVDKARHVETQSGRDSHGNFTVYSTRDCSLQRRNQKLVEEAPAPFLPEEIVSTLEEYSRRLFTTVGYVGLGTCEFMVTPNGKVYFLEVNPRLQVEHTVSEEVSGLDLVREQLNIAAGGELTRAPEPRGHSFELRITSEDPATNLTPGSGTLEKIQWPAGPGVRIDTGVEQGDTISPKFDSMMGKVIVTAQNRLDAVARVRRVLDELVIEGVPTPIPLFKEIFRNDDFTAENGHPFSVSTKWLERTYLNRTPASASSGQPASLAGAAAPAAPDKSTSETFVIEMNNRRVKLTVPLDIVENITGSARARGAKRPTQPLRGAGLHNVASGAAKANDGAKSGVIASPMQAVVTRINVSEGQQVAKGDLLVVLESMKMENYVYAPAAGEVKKIFVGPADGVEAGDTLVTLDVAKAEDSKKEGGND
>NZ_AP012324.1|WP_003829794.1|1998448_2000071_-|acyl-CoA-carboxylase-subunit-beta
MTDIMDSPAVNAVTATSATNASQPPAHQPLRTAVVKAAELARAAEERARDKQHAKGKKTARERLDLLFDTGTFEEIGRFQGGNIAGGNAGAAVITGFGQVYGRKVAVYAQDFSVKGGTLGTAEGEKICRLMDMAIDLKVPIVAIVDSGGARIQEGVAALTQYGRIFRKTCEASGFVPQLSLILGPCAGGAVYCPALTDLIIMTRENSNMFVTGPDVVKASTGETISMADLGGGEVHNRVSGVAHYLGEDESDAIDYARTVLAYLPSNSESKPPVYAYAATRAERETAKRLATIVPANERQPYDMLEVIRCIVDYGEFVQVQELFGASALVGFACIDGKPVGIVANQPNVLAGILDVDSSEKVARFVRLCDAFNLPVVTLVDVPGYKPGSDQEHAGIIRRGAKVIYAYANAQVPMVTVVLRKAFGGAYIVMGSKAIGADLNFAWPSSQIAVLGAAGAVNIIHRHDLAKAKASGQDVDALRAKYIKEYETSTVNANLSLEIGQIDGMIDPEQTREVIVESLATLATKRRIKRTTKHHGNQPL
>NZ_AP012324.1|WP_003829795.1|1988926_1998409_-|type-I-polyketide-synthase
MSTFFLNRLTTEPHALAFAGQSTPWPVALADQTTDPSLDEALRGHVAAANRLLSPAAADLLATTGRPVDLFGFTPNPAHLSAAADATASVEGVALTQLGALLDLEHLGYSVAAAKPVAVLGHSQGVLAVHMTRAIEAAGSIEAAGKTLDEILAVAALIGAAGTRRVRELGLNPKYGEASPMLSVKGATREQVEALVKRVNNARGPISIAVTNSDNHHVLSGYPEDLAALAFETEREHKHQAKLREQKLHGGTVFNPTLEYLEVTLPFHSPLMAEAVEQTVSWAGACGFDQDRTRALAEEVLLNHVDWNARVKALFNAADPAKLWIVDLGPGNTLGKLIGNVVQGTGIGVVEATTLAERSALSTLESEPERTQNWKALAPRVIETPAGAKLVTKFSKLTGKPPVLLPGMTPTTVEPEIVAAAANAGYWAELAGGGQVTAEVFDRHIAALEDELEEGRTVEFNAMFMDRYLWNLQFGSSRIVPKKRASGAPIDGVVVSAGIPELDEAVELIKNLQADGLPYVSFKPGTVDQIRQVVRIAKAVAPTTIMIQVEGGEAGGHHSWEALDDLLAATYAEVRACDNLVLVAGGGIGTPERAADYISGQWAHAYGLPDMPVDGVLIGTAAMTAKEAHTSPEVKQMLVKTPGIPADAKSDDVFAPQAAHWVPSGKSVGGMSSGLSHLHADIYELENDSAECGRLLVRVMKHPEELDSRRKEIIEALNKTAKPYFGDLASMTYLEWAQRFAELAFPWADPTYADRFQHLLQRIEARANDTDSGEFTSKLFAADGVSADEAAAAGLLTRDGILADPAPALEKLALAYPQTAELKVVPADVAWFPVLVREYPKPMPFVPVIDNDLLRWWGQDQLWQSEDQRYSADSVRAIPGPISVAGITTVDEPIADILGRFENAAIERVKAEQNASESNDFAALGEAVSAEDFIRKSPNISWVGHIADNPAYGTALGDQYYEIRAFDAAAGKYDLDIHLDTYWDNDPDGGTSKHAVRDIVIPLIVEGTEPGRVPVVDRERLIPDVYAMLAATAGIGNTAITGDKLTAMPTLSVPSDEGAVTANAVTEGETAQNRPFGTATATYTLSANLGFDHEAATGAALPAALQPSRIAPDALVGPAWPAIYTALGSVYVKGYPVIEGLLNAVHLDHLIELEVNEEDLLKHTGETITLKSWAEDYFESASGRVVTIHVTHTAADGTLLARETERFAIRGRVYSDALPADAPEFGDAEHAEVAPTPRRLLRRVKVVAPHDMTAFARTSGDFNPIHTSTRGARISGLAAPLVHGMWLSATAQHAVQALDEKGARYEIAGWTYNMYGMVQLDDTVEISVERVGKVRHGGMTLEVTCRIDGQLVSRGTALVRAPRAAFVYPGQGIQKQGMVLDERAKSAAARDVWERADKLTRAKLGFSILGLVRDNPKELTANGVTYRHPEGLLNLTQFTQVALATVAFAQTARLREAGADVWPAYFAGHSLGEYNALSAFADVIPLETVLELVFHRGSTMHHLIERDAQGRSNYRMGALRPNQFGVDDAHVKEYVESVAKASGEFLEIVNYNLAGQQYAIAGTIAGLKALKADSARRVAAFGGKPAFMLVPGIDVPFHSTLLRKGVPEFRDKLDALLPAYIDYRGRLVDRYIPNLVASPFEMTKEFAAKILEVVPSERIKAALDDPAVWDSYAADDQKLGRLLLTELLSWQFASPVRWIETQALLFGKREQGGLGVEEYVEVGLGNAPTLANLGAKTLRLPEFAGNNTVVYNVGRDEGRVYMTDTDSLVPDDEPEETAAPVETAPAGGSAVAKLGSSAAADAAPAAAAAPAPAAPVSAAPAGAPSGAAVADLPFKASDGIGVLMAYAAKVRLDQIGSNDTTDTLTNGVSSRRNQLLMDISSELGVASVDGAAEATLDKLAQIVNKAAPNYKPFGAVLSEALRDRLRSLFGAAGVKQQYIRDRVANVWQLGEGWVASVLAALLLDTREGSSSRGGDLAKLPTAAVQNKPEADKLIDAAVEVVAQLKGVAVALPSAGGAAGGAVVDSAALDAFAEKVTGSNGVLAATARFVLNELGVAAPAPEESEDENAAVVAAVEAELGSDWPKQVAPRFDANKAILFDDRWASAREDLARAYYDNDPAALNGSFIGLGKTIAAEAQWFADKSDNDELKDAFQKAASEALESVTSDKNASRYANDIAIVTGVSPNSIAAQVVEGLLAGGATVVATSHSFKPSIKAWAKQAYREHATGNAKLWLVPANLSSYRDVDALVDWVGHEQKKTSGATTTILKPAWEPTLFFPFAAPPVHGTLADSGDLFESQARLMLWGVERAIAGFSHIGADTNVQHKLHVVLPGSPNRGVFGGDGAYGEVKSAFDAIVNRARAEKVWSSRVTFAHPKIGWVRGTGLMGGNDPLVAVVERHGIHTYSTAQIAAKLLDLCTTESREQALKAPLDVDLTGGLGSEPIDIKALRAEAMADAEKEASSEKVAIEGEKPEGGAAGSTLKALPTPIVTKQASVDLADWQNVTAKPKDEIVIVSVGELGPWGSGRTRTQAELGIHPDGTVDLSAGAVLELAWNMGLLTWADSPKPGWYDTDGNLVPEEDIAERYHDEVVARSGIRPFEEGMGDDYKDGADEEEAEVFLDHDVTFSVPTRDVAAEYVKLDEAHTTIAPDEESGEWNVTRHAGSMIRVPRRATMTRTVGGQFPKGFDPTRWGIPASMVGDVDKIALWNIVTTVDAYLGAGFTPAEILESIHPSLVASTQGTGFGGMMSMRKLYLDRFLNHEIPTDILQEALPNVVAAHVMQSYIGGYGNMIQPVSACATAAVSLEEGVDKIALGKADFVVTGAIDDIGVESVIGFGNMNATANSEEMYGKGIDARFFSRANDRRRGGFLESQGGGTILVTRGDIAEKLGLPVAAVVGFIHSYADGAHTSIPAPGLGALAAGLGGKDSKLVHDLAKLGVSADDIAVVSKHDTSTNANDPNESELHNTLAHAIGRTDGNPLFVISQKTLTGHAKGGACIFQVNGLTQLFKSGVIPANASLDCVDPKLQRDDHMVWVRKPLRIGGGEDEFGRETAGRPVKAGLATSLGFGHVSGFVALVHPGAFEAAVAKADGEAALEAWRERANARLAAGQRHLEEGMMGRAALYEPIDNRRFHEDHRGYDHHEVEKSMLLNPDARLGADGYYEA
>NZ_AP012324.1|WP_080543816.1|1987679_1988054_+|NAD(P)H-dependent-oxidoreductase
MRTLPTTNANPPAAVASARKAVVEADGVWIFSPEYNYSYPGVLKNLLDWLSPPAGAVPGRVRFRDGRQEGRPVRCRRSVRRRRHARQAQRGAGLWQDRTAAHRQAGRSGSGSRGLGHRQAHPVR
>NZ_AP012324.1|WP_003829783.1|2009245_2010199_+|hypothetical-protein
MKTHKEVAALLQTAQREQRCAIGDGGKLYTALRRRTKIGEVVSPYPNLFAATSYWKSLNVEQQSMHLIRALAKVHPTWTFAGLSAACVYQYEHSYSLHNGTVDIVSPKGANCGGASGLNRIYMARCSQYRCQGILVTSPARTLIDCASLPFDKALAIYDSALRLQHVTKLDVETLIVQTDCNETNVKRLLRYANPLRENGGESWAYARIRQLGFAEPLFQTEFDNPANPEMPYRVDFCWKLHDGRIIVVEYDGIAKYRDTSNPNRANLMAKFEYERQRDTNLKTQGVTSIKHLFYEDVSDLKRLNALLTAIGIPKIR
>NZ_AP012324.1|WP_003829782.1|2010554_2011382_-|transcription-termination/antitermination-factor-NusG
MSDELNLENLDAALENVDAAADEAPVADAPAEAVESAEPVAEAPVASPETVAESAEEESEVNESEQAEETDAGQKAVDEFSKSLRTLDGKWYVLHTYSGYEKRVKTNIESRVASFGMEDQIFQVEVPMEEVEKHTEKGKKVITRVRVPGYVLIRMWPDENARRVVRETEGVTGFVGPSKDPAPLSRQEVVAMMAPMIASEALKAAGDKPAAAKKRKVEVSYAVGDQVTVTDGPFATMAAVVSDVEPTTQKLTVLVSIFGRDTPVELGFHQVQKLD
>NZ_AP012324.1|WP_003829781.1|2011414_2011642_-|preprotein-translocase-subunit-SecE
MAKTSANEKAVKPNVFMRIGLFIKQIIDELRKVVTPTAKELFFWSLAVFIFVLLLMALVTGMDFGLGKATLGIFG
>NZ_AP012324.1|WP_032738292.1|2011971_2013177_-|pyridoxal-phosphate-dependent-aminotransferase
MAQWQILSDRINTVAPSATLAVDSKAKAMKATGLDVIGFGAGEPNFPTPANVVKAAADACLDPKNYKYTPTPGLPELREAIAAKVLRDSGYEVSADQVVVTNGGKQAVYEAFQILLNDGDEVIIPTPYWTSYPEAVKLADGVPVEVFAGADVNFEPSLEALEAARTERTKAIIVNSPNNPTGAVWKPETVEAIGRWAVEHHIWIISDEIYEHLNYDDARTTYIGAAVPECRDQLLVLNGVAKTYAMPGWRVGWMVAPAEVAKAATKLQGHMTSNVANISQRAALAAVSGPLDEVYEMRKAFDVRRRAIVAALNDIEGVYCPTPTGAFYAFADITALLGKPLGSNGTVCATSADFAAALLDEAHVAAVPGEAFGAPGYLRFSYALADDDLAEGMKRFKDWAK
>NZ_AP012324.1|WP_032738291.1|2013318_2014581_+|polysaccharide-deacetylase-family-protein
MAKHHESHGSRGTRRSTVEPRVAYSRHAETHSAHGSQLHYGQHASHRSAAAIAAQRTRRIAVLVVAAVVAVALVITVGVVAHGWFVRQSAPSMQQQLPTTAHKSLTRKTVPQLDPGNIVIGVNGSETTYVLKGEQYVEGGAHAIEPEDGVLTGNIVTTGTVDTNTPGDYTVQYTVHDSTGHEASATRTVKVVDTMDKQTGGIPVLMYHYVYDPANPPADVDANWIPTTSLEPQLQYLTQNNFYYPSWPEVRAFIDGKHSLPKNSIVMTFDDGEPHFFQYGSPLLAKYKVPATSFIIGADGEALNKMKTYATPYLEYESHSFDMHRAGGTVGHGGRISAMSHQEIVDDLKQSEQVTGSLQAFAYPFGDTTPDAIEAVRETGTLAAFTTQYGWADVGADPMNLPRVRIQGTGSLDTFIAAIQ
>NZ_AP012324.1|WP_015439254.1|2014676_2015810_-|glutamate-5-kinase
MSTPSQAEVRRMIAAAGTIVVKVGSSSLTQPSGHLDPDKLDALTAALAQVRLMGARVVLVSSGAIAAGFGPLGFDERPADVATQQATAAVGQGLLMARYEAAFGRFGIRVGQILITAEDTIRATQYRNVERTLDRLLDLGVVPIINENDSLASNEIRFGDNDRLSALVANLVRAEALVLLTDVDALYTAPPAQPGSRRVEYVPNVIDALGDIQVSGSGSKVGTGGMVTKLEAARVAAVSGIPTVLTCASNAGPAMMGDPVGTVFAPVKARGSSRRLWIGFAAEPRGTIVVDAGAAKAIRGGRASLLAAGALDVHGDFSAGDPVWIDDESGTHLARGLAGFDSEEIPQTLGRNTAQLKRFLGDQYAHPLVHRDNLVLV
>NZ_AP012324.1|WP_003829777.1|2015915_2017607_-|GTPase-ObgE
MSDFVDRVTVHVRGGDGGNGSAGIRREKYKPLAGPNGGNGGDGGSVVFVADRNATSLLDYRFMPHRTAGNGTMGLGDNKDGSKGEDLILPVPCGTVVFEARGEQGKTKHPGEQLADLRHEGDRVVVAQGGAGGLGNIALANKTRRAPGFALLGELGEERDVILELKSIADVALVGFPSAGKSSLIAAMSAAKPKIADYPFTTLVPNLGVVIAGDSRYTIADVPGLIPGASEGKGLGLEFLRHIERTEIIAHVIDCATLEPDRDPMSDYQALENELALYADKLELPLGAIPIPERPRIVILNKIDVPEAKELAEFVRPEFEKLGLKVFEISTASHEGLKELNFALAELVHEMREEVASREEAEEEARVVIKPLERTGRRPRRADEGGNALDFTVERRELGNGEVFYEVRGAKPERWVMQTNFDNDEAVGYLADRLAKLGVEDELRRKGARPGDEIRIGRGDRMVEFDWDPTISAGAEMLDGSNLGARGKDLRLEEQDPRAHRRSNAERRAQYHEMMDARAAVRDAMMAERKAGHWADPTVDDDRHDETSLFGHGESADDSASEE
>NZ_AP012324.1|WP_003829776.1|2017673_2017925_-|50S-ribosomal-protein-L27
MAHKKGASSSRNGRDSSPQYLGVKKFGGEAVVAGNIIVRQRGTNFHAGQNVGMGKDHTLFALADGSVKFGVRRDRKVVDVIAA
>NZ_AP012324.1|WP_014484324.1|2017947_2018256_-|50S-ribosomal-protein-L21
MYAIVKAGGHQEKVEVGDTILVNRLDAKKGDTVEFPVALLVDGAKVTLAAADLAKVSVKAEVVNDEAKGPKINIQKYKNKTGVARRKGHRQPLTIVKITAIA
>NZ_AP012324.1|WP_032738290.1|2018442_2021538_-|Rne/Rng-family-ribonuclease
MQRAARSIVPTENREGFVGDETDNSTVSNTESQASGASEPNAEASQPTRRRRGGRRVVRGTGAAGASLELQVQEHAAPLFEAPALPDADASASAETTDNNASDDEKHPARRTRSRRSADNADYEDRPTRRRAVADDDDEPRPVRRRRTVSDDLEEDDERPIRRRRVASDDFDEDNDRLVRRRRSVIDDLEDDDAPRSSRRRTAVDDSDEDGDRPVRRRRSTTNDRDDRDDEPRSARRTRSRRSSEDAREENPDERVLDVIDALPAGHESARRGKPMTSLLFQEPVLPDMRRDDRDDEEDDGEQRSRSSRRSRAREDEADYEERPSRSRRSNRSDHGDHDDRDDHDDRDDSRNNRRRNEAQDDFDADDQSDSRRSRRSRRLNAQERRAAAEVEQIEEDLELDDITYSPIAEEENDEESDSTRTRSRRRRRRGSRNESGASNNDSESSENNGDDSRRRRDDRDERDRDDDEEQTVTRRRRRRRGGKNAESGDEQDDQQLTRRSRKQQYIDEITDVEGSTRLEAKKQRRRDNRRERSRQSQLMEQDFLARRENVDRLMVVREKEHHTQISVVEDNILVEHYVSDIQEVQTVGNIYLGRVQNVLPSMEAAFVDIGQARNGVLYAGEVNWDAARLEGQPRRIELAFKSGDPVLVQVTKDPIGHKGARLTSQVTLAGRFLVLVPSGGMTGVSRKLSERERSRLKGIVSKIAPKDMGVIIRTAAEGASEEAIVKDLESLVRQWERINAKREEFWHGKRPKLLQGEPDVAIRVVRDIFNDDFGKLIVEGDKVYGRIEEYLDTMAPDLKDKLEKWDPAEHEGKDVFDKWQIDSQLRKGMERQVYLPSGGSIVIDRTEAMTTIDVNTGRFIGKGKSLEETVTRCNLEASEEIARQLRLRDIGGMVMIDYVDMVMPANRDLVLRRLVECLARDRTKHQVAEVTSLGLVQMTRKRIGQGLVEAFSEECPTCKGRGFILHDQPTVSADYDDPYALRGGDPFVKTNKHGRGTAPAPEPAGSSADVKAKLAQIAAAAVAANNTEEE

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Crispr_ID: NZ_AP012324_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP012324_3

2130541-2130625

Orphan

Consensus_repeat	Method
CCTTCCCGAATATGTACCACTGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP012324_3

>merge|NZ_AP012324|3|2130541-2130625|CRISPRCasFinder
CCTTCCCGAATATGTACCACTGACAACGTCGTAGCGTCACATATTCAGGAAACAACCCCACACCTCCCGAATATGTACCACTGAC

>NZ_AP012324|3|3|2130541-2130625|CRISPRCasFinder
CCTTCCCGAATATGTACCACTGAC	AACGTCGTAGCGTCACATATTCAGGAAACAACCCCAC
ACCTCCCGAATATGTACCACTGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP012324.1\|WP_025263332.1\|2142006_2142639_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_025263331.1\|2139864_2141730_-\|methionine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237029
NZ_AP012324.1\|WP_015439310.1\|2142629_2142977_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_003829636.1\|2135078_2135249_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_003829635.1\|2135365_2136682_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|224292
NZ_AP012324.1\|WP_003829642.1\|2124881_2125646_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|129396
NZ_AP012324.1\|WP_003829637.1\|2132747_2134658_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_AP012324.1\|WP_003829648.1\|2116022_2116739_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_003829647.1\|2116944_2117904_-\|L,D-transpeptidase	unknown	unknown	gnl\|CDD\|341130
NZ_AP012324.1\|WP_003829640.1\|2126919_2129331_-\|KUP/HAK/KT-family-potassium-transporter	unknown	unknown	gnl\|CDD\|376906
NZ_AP012324.1\|WP_003829622.1\|2143096_2144116_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223390
NZ_AP012324.1\|WP_003829643.1\|2123336_2124521_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213222
NZ_AP012324.1\|WP_003829646.1\|2118000_2119794_-\|glycosyl-hydrolase-family-25	unknown	unknown	gnl\|CDD\|119376
NZ_AP012324.1\|WP_032738331.1\|2139061_2139355_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP012324.1\|WP_003829638.1\|2130742_2132548_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_AP012324.1\|WP_003829633.1\|2137034_2137283_-\|family-43-glycosylhydrolase	unknown	unknown	gnl\|CDD\|350118
NZ_AP012324.1\|WP_003829641.1\|2125775_2126636_-\|class-II-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|238889
NZ_AP012324.1\|WP_003829639.1\|2129529_2130489_-\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|238635
NZ_AP012324.1\|WP_003829644.1\|2121879_2123340_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376899
NZ_AP012324.1\|WP_003829645.1\|2120069_2121575_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673

Protein	Function_ID	Function_description	E-value
NZ_AP012324.1\|WP_003829622.1\|2143096_2144116_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	8.88393e-106
NZ_AP012324.1\|WP_003829635.1\|2135365_2136682_-\|ATP-binding-protein	gnl\|CDD\|224292	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only].	7.92634e-27
NZ_AP012324.1\|WP_003829642.1\|2124881_2125646_+\|HD-domain-containing-protein	gnl\|CDD\|129396	TIGR00295, Uncharacterized_protein_MJ0778, TIGR00295 family protein. This set of orthologs is narrowly defined, comprising proteins found in three Archaea but not in Pyrococcus horikoshii. The closest homologs are other archaeal proteins that appear to be represent distinct orthologous clusters. [Hypothetical proteins, Conserved].	3.35054e-14
NZ_AP012324.1\|WP_003829637.1\|2132747_2134658_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.38011e-172
NZ_AP012324.1\|WP_003829647.1\|2116944_2117904_-\|L,D-transpeptidase	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	1.65635e-18
NZ_AP012324.1\|WP_003829640.1\|2126919_2129331_-\|KUP/HAK/KT-family-potassium-transporter	gnl\|CDD\|376906	pfam02705, K_trans, K+ potassium transporter. This is a family of K+ potassium transporters that are conserved across phyla, having both bacterial (KUP), yeast (HAK), and plant (AtKT) sequences as members.	0
NZ_AP012324.1\|WP_003829643.1\|2123336_2124521_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.03621e-22
NZ_AP012324.1\|WP_003829646.1\|2118000_2119794_-\|glycosyl-hydrolase-family-25	gnl\|CDD\|119376	cd06414, GH25_LytC-like, The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a C-terminal glycosyl hydrolase family 25 (GH25) domain and an N-terminal choline-binding module (CBM) consisting of eleven homologous repeats that specifically recognizes the choline residues of pneumococcal lipoteichoic and teichoic acids. This domain arrangement is the reverse of the major pneumococcal autolysin, LytA, and the CPL-1-like lytic enzymes of the pneumococcal bacteriophages, in which the CBM (consisting of six repeats) is at the C-terminus. This model represents the C-terminal catalytic domain of the LytC-like enzymes.	1.54318e-68
NZ_AP012324.1\|WP_025263331.1\|2139864_2141730_-\|methionine--tRNA-ligase	gnl\|CDD\|237029	PRK12268, PRK12268, methionyl-tRNA synthetase; Reviewed.	0
NZ_AP012324.1\|WP_003829638.1\|2130742_2132548_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	9.82787e-175
NZ_AP012324.1\|WP_003829633.1\|2137034_2137283_-\|family-43-glycosylhydrolase	gnl\|CDD\|350118	cd09004, GH43_bXyl-like, Glycosyl hydrolase family 43 protein such as Bacteroides thetaiotaomicron VPI-5482 alpha-L-arabinofuranosidases (BT3675;BT_3675) and (BT3662;BT_3662); includes mostly xylanases. This glycosyl hydrolase family 43 (GH43) subgroup includes enzymes that have been annotated as xylan-digesting beta-xylosidase (EC 3.2.1.37) and xylanase (endo-alpha-L-arabinanase, EC 3.2.1.8) activities, as well the Bacteroides thetaiotaomicron VPI-5482 alpha-L-arabinofuranosidases (EC 3.2.1.55) (BT3675;BT_3675) and (BT3662;BT_3662). It belongs to the glycosyl hydrolase clan F (according to carbohydrate-active enzymes database (CAZY)) which includes family 43 (GH43) and 62 (GH62) families. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	3.79201e-26
NZ_AP012324.1\|WP_003829641.1\|2125775_2126636_-\|class-II-glutamine-amidotransferase	gnl\|CDD\|238889	cd01908, YafJ, Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II glutamine amidotransferases including glucosamine-fructose 6-phosphate synthase (GLMS or GFAT), glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase), asparagine synthetase B (AsnB), beta lactam synthetase (beta-LS) and glutamate synthase (GltS). The YafJ fold is also somewhat similar to the Ntn (N-terminal nucleophile) hydrolase fold of the proteasomal alpha and beta subunits.	2.93876e-38
NZ_AP012324.1\|WP_003829639.1\|2129529_2130489_-\|TatD-family-hydrolase	gnl\|CDD\|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	8.56499e-81
NZ_AP012324.1\|WP_003829644.1\|2121879_2123340_+\|ABC-transporter-permease	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	9.09529e-11
NZ_AP012324.1\|WP_003829645.1\|2120069_2121575_-\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	1.26328e-36

>NZ_AP012324.1|WP_003829639.1|2129529_2130489_-|TatD-family-hydrolase
MSKHHHRDRSWAPAPEPLPQDAQTIDNHTHVASVIPFARAMSHEAQEKGQPEVPVYDVDQLLAQAQAVGIGGIIDCGCELPHLMTAVQMALDHPGNVHAALAIHPNESVLHGHRGVPGPDGLPLKYKPYHDTSFEDALAEVHRLATTYPEQVVAIGETGMDLFRTGEGAKELQREAFRAHIALAKELNLPMQIHDRDSHREVIETLLADGAPERTVFHSYSGDREMGEIAREHGWYLSFSGTVSYKGNDGIRESMRIVGLDHAMVETDAPYLTPMPYRGRTNAPYMIPYTLRAMADTLDLPIADVARGTRNTTRVVYGV
>NZ_AP012324.1|WP_003829640.1|2126919_2129331_-|KUP/HAK/KT-family-potassium-transporter
MAESDKQAERAQKAAKPQKAQKTNAKAGANKAKAKQEEEALLRADTFTNAPKVSRRTLTKEEREAIAKQREAETREAEKIASASSKGRLGRWWARLQSGPDKVTWGMAIVALGVVYGDIGTSPLYTAQTFLAGQGGFGNVDREAVLGMLSLVFWSITLITTVKYVLIAMRIDNNGEGGIFALYSLIRKYGAWLAIPAMLGGAAFLADSVLTPAVSISSAVEGLQTLPPLEQLFDENPSLTLMITVVIIVILFSVQSRGTESIGKVFGSMVLVWFSFLAVVGVVNLNNDWSVFAALNPVYGVKFLFSPHNAAGIALMGTVFLSTTGAEALYSDMGHVGRGNIYFTWPFIKIALVLNYFGQGAWMLNNARNPQFNTMKSLNPFFQMMTPNVRYLAVILSVTAGVIASQALITGAFTMVSEATRLNWMPHLQVRYPARTRGQLYIPVVNGVLCVSTLAVLAIFKDSEHISAAYGLALTITMITTTVLLGVYLWYDRKRVGAIVFTVLFLAIQIMFFIASMAKFLHGGWFTCLLTIAILFVMYTWNEGTKLERAQRRHMRPKDFLPALDKLHGDFRIPYFADNIVYLTSDSETKRLDTDIFFSIFADHPKRARAWWAVSVETTDEPFTREYSVENFGTNYIFRVRFRLGFKVSQSIPAYIHQIMHDLSKTGELPKQKSIYPRVDADPDIGTVRYVLVHKALMPESKVSARGALSLQAKYAIRHVAGSPVKWFGLAPYNPLIEVQPLFVSTRRPPRLKRTDGTKTVPAPTPTRSVADPAAVPDPMDTTAGLSRLVQELDAAMSAEEKK
>NZ_AP012324.1|WP_003829641.1|2125775_2126636_-|class-II-glutamine-amidotransferase
MCRLLGYATAGFNLSLNAVLGQGNVEDFRELSEIHNDGWGVAQLADPASAPYVRDGGAPTPETGTKIYKSTIAARADSTFEALASEPARGAIWHLRLASSNLPLIMENQHPFYANGLSFIHNGDISDANGRNIVTNRSYPVDHSVFLSTGGRSDSAIFFAVILEYVGFGFPLDEAVAQAVRELRQAYPKSSYNCMIQSEDQLIALCAAGREKTSPRIVEIYDEYGRGEQAADYRVMRYHALNDENGDPAGVVVSSSGYEQEGWDVLENDQMIIASNRNGTYRLRSI
>NZ_AP012324.1|WP_003829642.1|2124881_2125646_+|HD-domain-containing-protein
MTGYIPTLEQIDELHRKIAPSEAAYELVHTHCVIVATIGCQIVRRQNALFTRRCTLPKDAPEWGSNRRTENTVDAAVSATPMPPTAGVTGGQVPPRLLDEHLVLIGGLLHDIGTYRVFKHDGSDGEPLKFSKKRYILHGLKGYEYLLDEGVDEYIAQFCRNHTGVGLTCEDVVKQELPLPPADYVPMNLEQEVVMYADKFHSKSVPPKFLQVEAYTARAERFGEDNKRRWLDLVAKYGVPDIPVLAEKYGMRVI
>NZ_AP012324.1|WP_003829643.1|2123336_2124521_+|ATP-binding-cassette-domain-containing-protein
MSEKNEQELSKDEALKNTAESAMASKDAIKPAPADSIQFSVIFDDADGLDLEGADDADDNASGDIYSIMASAESAADVTEASDATAEDNAGAELSEAEADALASADTSAAATKRNADRVNETLNLAKSGGKDELVEHAAPAAKATEPTMTLASRIDRVLVGGGADDILLKTYPTFALNKVTVPGAKGKINVLDSVEFACYVGHAYALLITDDPDSGLTADTKRRALMGVMSGLVQPKSGTVMNKSANIAELEPVDLRGHRLGIVPQLHAVQPDLDAEQNVLYAMNASNRNFLKPKPVIARELLAKVGFSEATSGVAVSKLPVVQQRLVAIARAISTEAEVLILDEPTRGLNVDDTVTVFAALAKLAHSGDPKHCIIVLTASREIAEAADQMFEI
>NZ_AP012324.1|WP_003829644.1|2121879_2123340_+|ABC-transporter-permease
MFVLSNAWRALMRSKGRTTLTAFITLAVTFGTVAGLAIVQENTTAHTTTYNSQKANMAIRPSAATWKKVSATDSATTKHYMTWSSYTDYASAIQTAGTTLDFTVTGTVPARVSGDLKALDGGSLGSASDDKTGGQLVWRAFWTKDAAKASDLGTFEIVDGKGLSYNNKSANPDTTGALVSEAFAKANNLKVGDTFKVATATSASDTAELKVRGIYKYTSESTVDNPVVAARNRENAIFTNYQTFSKAGLDPQYSNETASGWELPDLNVVFNVTDSATYDSLLKTLKKAKLPAKGYTISSPSLEAYTKSLEPLDTLAARAKTGVIVLLTVGGVLLLALVLLAAWTPKRNDEIGMALVSGVTRGRLGWQFMLEVFFATLPFYVIGLVGGAFAAKPIGAALISGHTTAVTSSLIWQMVWGGLGAILALAILAALRLAFFSAAKLFAADGDWGTVSEIETIEEADDEVAELGKAVTTTTTTSNDDAEAKA
>NZ_AP012324.1|WP_003829645.1|2120069_2121575_-|LCP-family-protein
MRNGLDIGKSIARLGRLQHMPDASVLRNREAKDMANRHAQNNLPNFGWQKVRGPHHIMAYRTSRKAAAAVSMAVIAVLVFVGTFAAATWADVSGAVSSQKVQVIQQKGAKKVDDSPVDPYANKVINILLIGQDTRDGAGNSAIGGSGSDVADLHNSDTTMILQIAADRKSMNLVSIPRDLMVSTPGCQTTNGEIAAQSSVMFNSIFANGYSQGGDVASAASCTMNEVNHLSGLDIQNFMVVDFGGLVNMIDAIGGVDICIPTQMTDVYTGLNLSPGMQHLTGGLATQYARMRHGTGTDGSDTMRTTRQQYLIRQLVKTALSKNYFTQTSELYQLAKSALDSVQMSEGLANVGTLAGLATSLKNFSMDNLYSMTIPITPWVEDPNRSQLADGADAVWEKLRKGQPLVDKAETAATVDGTTTTDGTTADGATADGTTADGTVTDSSTYNEKIGVITQADGTLIDAQTGGIIDPETGAIRSSVTGQFIGMNNRYIEVTYCGVTY
>NZ_AP012324.1|WP_003829646.1|2118000_2119794_-|glycosyl-hydrolase-family-25
MSAKRMMSAVAVLASMTLVSAVCAAPASALSDVSVDALADASTDPFRTQTISDDTAADAMPDNPDAALPDQVSAAIPDDATVVSEDHAVTADGELKNITTGETVTDPALVGTQDSQPDPLAKTDGESFIPVQADEVKQKVAANGGDANAGAADAQTAPDTPDTQPEQPRPNDSSDSEQPNQSDSSAPSDSASTSDSGEAIGNASDSATATNGAAKATTKGSVRLAALQNNEYGAHWGSYNGTAAFFDASNNLFVQQAKGVIDVSAWQGNINWQAVKNSGVEGAIIRIGYGWDNGFDKQALRNISECRRLGIPFGIYLYSYAYDANTGAAEGSSLVNLLQKAGVSSSDLGYPVYYDLERWTWTGHEVPNDPGTYDGIVNAWYGRLQSAGYNNLAVYSYTSYLNTALNSGNIHSKTRWVAQYGSSMGYTAFPTNDRGWQYTSRGSVSGISGTVDLNAFGNQTATSSAPSVPVYRVYNPNSGLHHYTMNYNEVIMLVGKGWRYEKTAFRAGQSGIPVYRVYNPNDGNHLFTMNSYERDNLARLGWHDEGVSWYVPSGGSINVYRLYNPNNGEHVFTTEYGEYVLVGRAGWHQEGVAWTSL
>NZ_AP012324.1|WP_003829647.1|2116944_2117904_-|L,D-transpeptidase
MRRTITKHAFVVIAVMAAFMAVLLSPIPQASADEGSRDMYRLYNPNSGEHFYTADSNERDHLTGVGWVYEGIGWRAPVQSSVPVYRLYNSNAGDHHYTLNSYERDMLVSKGWRYEGIGWYSSDTNRSYPLYRQYNPNAKAGAHNYTLNSNEKDMLVRAGWHDEGLAWYGVGPGEGAPVPQYQRPSGGTYPNLSVTPNLSINVSIADQRVYVKSGSNVIYTLIASTGVNNATPRGTFRIGNRGSSFYNAREGMGANYWVAFEPTNTYLFHSVPTNSSGQYIVSEGYKLGQPASHGCVRLSIPDAQWFYQQLPSGTVVHIF
>NZ_AP012324.1|WP_003829648.1|2116022_2116739_-|hypothetical-protein
MRITMKRICAVISGLMMVLSIAMAVSGPAHVAYADEGSQEMYRMYNPNSGEHFYTANSYERDNLKSLGWHYEGVGWVAPVTSSVPVYRLYNSNAGDHHYTMNSYEKDMLVSKGWRYEGIGWYSADTTNEFPLYRQYNPNAKAGAHNYTLNSNERDALVRAGWRDEGLAWYALGLGGPAQSQPSTPSRPSGPATVPGAITPGAWCKKIEAGQYGRSEDGDLYQCSYQPGDKIPHWYRVQ
>NZ_AP012324.1|WP_003829638.1|2130742_2132548_-|ABC-transporter-ATP-binding-protein
MAQRNTFREDEELEESINLHDIARVGKYLKLYISRIVRILAVVVSMSCIVVSVPYLTKIMIDDAIPNKDLGKLAMLAGGLFCLIVIYELALRYRTVDITRVGQLMLKDMRRDLFTYIQTLPFSYFDSRPHGKILIRVVNYVNTLSDTLSSGLINVFSDIFTFFVTLIVMFAIDWQLALWSLVLFPVLIIWVRVLQYFQRKAYQVLSNKQSNLNAFIHESIAGVKTTQTFAREKEQFDTFQQQQDDVRTAWMAAKHIEFLMWPGVQTISVMTIAFIYFVGITGFGGVSVTTGMLIAFVGYANNFWNPVINIGNFYNQLVTCSAYLERIFETLDVKPEIANKPGATELPAIQGKVDFNDVVFRYEDDGRNILNLVDFHVTPGKTIALVGPTGAGKTTIVSLLSRFYDVSEGSVTIDGHDVRDVTLESLRRQMGVMLQDTFIFSGNVRDNIRYGKLDATDEEIEAAAKAVHAHEFIMELPDGYDTTVEERGSTLSAGQRQLIAFARVLLADPRILILDEATSNIDTRTEEALQAGLRHLLKGRTSFIIAHRLSTIENADQIFYIDHGQIVEHGTHAELLEAKGAYYRLYESQYAMIRVATGATE
>NZ_AP012324.1|WP_003829637.1|2132747_2134658_-|ABC-transporter-ATP-binding-protein
MYVDPGINTSASNLKWVLSYCKPDLPRVAGALLLFIVNNTMALTIPILSGIIVDRVIVGGHTDELPRLCGLMILMTIIRVGARYGYQMWMERFGQNSVYRLVSDEYEKLHELDFTYFNHTRTGDIMSRLTSDTDAIRHCLSWVSYQIADCVVMFIGALCVMFAIDWRLALALACVTPFIFVLTRGLSTHAHPLFFAIRNSLASLNSMVEENIEGNRVVKAFVREPYETEKFDEHNDDYMQRNMALAYNSRKYMPWLDGLGFSLQLITLGLGGFLVIKGYMTLGNLVSFNSFLWMIDGPVRASGWLINDWQRFNASCIKIRKLLTEQPRIVEKPDAAEAVKQAVTIVEQVKRDDEATGATGAPGASGTYGARQSAERKSCPLRIKGDIRFAHVSFAFPDDPETPILKDLDFTVPAGSKLGILGETGAGKSTLVSLISRFYDPTVGHVLIDGIDARDWPLATLRSQVCIVAQDTFLFSDTIGGNIGFGASDDSDDRYIQKMAQIAGADNFIRSMPQGYDTVVGERGVGLSGGQKQRLSLARALADDPSILIMDDTTSAVDMETEAEIQKHLKEMDSGKTIVTIAHRISSVKDSDLILVLEHGRIVERGTHAELVAAHGRYWGIYHKQLGLQSGAAQGF
>NZ_AP012324.1|WP_003829636.1|2135078_2135249_+|hypothetical-protein
MPSGLQQLEVLRNRARLLHPETSHYMLFSKSGFDEHVAARAAQDGTVTLVDFADMD
>NZ_AP012324.1|WP_003829635.1|2135365_2136682_-|ATP-binding-protein
MLKRHAYDQLLNWKNRKTKQGLLITGARQVGKTTLIEQFGADHYEHVAKVNFIEMPQAVETVSKAKDTEDLILRLSVLSGTEITPGKTLLFLDEMQACEDMLTWTKFLSGAKGLDVIVSGSLLGIDVFNVRSIPVGFLQTMRMYPLNFYEFCAACRLPQLALDTLRECYVDRREVPDYLHERLTDLWYKYLLIGGMPDAVQSFVDSADIVKVRNTQQAIFDTYEYDITKYVSDLVERRHIKSIYEAIPSQLNAENKRFKFSKLGKNIRFAHMQTAFDWLANAGIALPTSRVQDPEYPLTEHADENTFKLYMNDVGLLTSRLMRSVDLEIVNHRSSMNYGSIFENAAAQELFAQGLELHYFNQNRIGEVDFVVQQGLDDISLVEIKSGKDYTRHRAMNNLLDTDNYRFAHAYVFHDGNVETVGRTEYLPIYMLGCLSVI
>NZ_AP012324.1|WP_003829633.1|2137034_2137283_-|family-43-glycosylhydrolase
MLLEQDPARKLYATGHHNIVNVPGTDEWIIAYHRFAYNPAGRWAGGDGCHRGVVFAPLDYNPDGSLVPVRPQVGSYVRSLAF
>NZ_AP012324.1|WP_032738331.1|2139061_2139355_-|hypothetical-protein
MYSVTFPGNLTQAESALVKRGTIQIAALLAAKITGRGLIINDGDIEYSWDFILVDASNDEQNTFDERLLRMLSDYIHAGFPDAVVRYTKHEAPKLSK
>NZ_AP012324.1|WP_025263331.1|2139864_2141730_-|methionine--tRNA-ligase
MSHVLVNVAWPYANGPRHIGHVAGFGVPSDVYARYERMKGNDVLMVSGTDEHGTPILVEAEKEGLTAQELANRYNRVIAKDLCDLGLSYDLFTRTTTGNHEHVVQEMFKQCLENGYIYKGTQQVAISPSTGRTLPDRYIEGECPICHAEGARGDQCDACGNELDPDELINPVSKINGETPRFEQTEHYFLDLPALAEANKAWLETRKGWRTNVINFSLGLFKEVKPRAITRDIDWGIPVPVKGWIDNPNKKLYVWFDAVIGYLSASIEWARRQGDPEKWREWWNDPKCPAYYFMGKDNITFHSQIWPSEMLAYNGKGSKGGETGPMGPLNLPEQVVASEFMTMEGKKFSSSRGIVIYVKDILARYPVDAVRYYISVAGPESSDSDFTWAEFVRHNNEELASSWGNLVNRVANLINKNFGEIPPLDEDSMTNEDRGLLEETSAAFDVVGSSIETHHQKHALSEAMRVVGDINKYISATEPWKIKDDQARLGTVLHVAAQAVADANHLLAPFLPHSAQKVWEALGGAGTFSPLPELKEVEDLDKPGFTYPIITGNYELGVNVHPWKSEAIEVGAVVPKPTPIFAKIPTEAVKEELARFDEALAARRAVEAERLAAEKAKLAAE
>NZ_AP012324.1|WP_025263332.1|2142006_2142639_+|hypothetical-protein
MTSTIANAGTARHTTVSLSVPPVLFTKDLPGPLSLSRLETFGTIRKFDESAGYWNEHANTLYGRAMIVSTVAPFGTVACALTAAWVWLGGPDFPRTIDVISTSHFRSTSAGRRIRVFRRVTSPEHIIRLGNLPVTTPQRTACDLVMGMDDAPDPSAINTLVCRLMTAYSFRASECLQIIKEHRHHKHAGRARIFFESLQRESEPALGQCA
>NZ_AP012324.1|WP_015439310.1|2142629_2142977_+|hypothetical-protein
MRITSRHASRRLDRLHQAQRLPRASDIQSHSPHASAAVNHDAPPSPPIALTPSVACSPDTPIEVLWHIAQHAPELRRWLIANPRADAALLEFISQAGGPGVKRALAVLLESMEEE
>NZ_AP012324.1|WP_003829622.1|2143096_2144116_-|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MTSADELNEQRDAEQSVAQVFERNDGNDGIDAGGPAASQTRESAVTIPAGTVVLAATPIGNVGDASARLVAFLERADIVAAEDTRRLFDLARRLGVYVNGRVVAYHDHNERDKADGLLDQVETGATVLVVSDAGMPTINDPGLAIVRRAIERGLPVTCAPGPSAVLDALALSGLPTDRFCYEGFLPRKHAERVQYLRTLLGERRTIVFYETPHRIADSMDDLLDAFGPNRPMALCRELTKDYEQIRRGPIGEIRQSVIDDPPRGEMVLVIGGASSEEAEAAAPSTLSVEDMAVLAIDRALEDGLRIKDAIAQVVQEHPLADGSLANRKQVYAAVLEIKG

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Crispr_ID: NZ_AP012324_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP012324_4

2159246-2159322

Orphan

Consensus_repeat	Method
GCAAATCCCCCAACCAATCGAAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP012324_4

>merge|NZ_AP012324|4|2159246-2159322|CRISPRCasFinder
GCAAATCCCCCAACCAATCGAAGAACCACCCCGTCCACGGACCCTCAACGGGGCAAATCCCCCAACCAACCGAAGAA

>NZ_AP012324|4|4|2159246-2159322|CRISPRCasFinder
GCAAATCCCCCAACCAATCGAAGAA	CCACCCCGTCCACGGACCCTCAACGGG
GCAAATCCCCCAACCAACCGAAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP012324.1\|WP_015439311.1\|2144776_2146195_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340890
NZ_AP012324.1\|WP_003829591.1\|2166772_2167486_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_AP012324.1\|WP_003829622.1\|2143096_2144116_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223390
NZ_AP012324.1\|WP_003829615.1\|2149210_2151079_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_AP012324.1\|WP_003829589.1\|2167557_2167935_+\|DUF4235-domain-containing-protein	unknown	unknown	gnl\|CDD\|379422
NZ_AP012324.1\|WP_003829587.1\|2168030_2168798_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|380322
NZ_AP012324.1\|WP_003829585.1\|2168963_2171711_+\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
NZ_AP012324.1\|WP_080543815.1\|2152360_2152588_+\|DUF1684-domain-containing-protein	unknown	unknown	gnl\|CDD\|377941
NZ_AP012324.1\|WP_003829606.1\|2159452_2160925_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_AP012324.1\|WP_003829607.1\|2158269_2158971_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_AP012324.1\|WP_032738281.1\|2147249_2149079_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_AP012324.1\|WP_172644904.1\|2154501_2158179_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274008
NZ_AP012324.1\|WP_003829604.1\|2160976_2161582_-\|DUF624-domain-containing-protein	unknown	unknown	gnl\|CDD\|377412
NZ_AP012324.1\|WP_014484409.1\|2162574_2163429_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_AP012324.1\|WP_003829597.1\|2163799_2164816_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_AP012324.1\|WP_003829594.1\|2165023_2166370_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|379175
NZ_AP012324.1\|WP_003829614.1\|2151262_2151784_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_AP012324.1\|WP_014484406.1\|2152724_2154248_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_AP012324.1\|WP_003829602.1\|2161732_2162575_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_AP012324.1\|WP_003829619.1\|2146299_2147241_+\|FAD:protein-FMN-transferase	unknown	unknown	gnl\|CDD\|376782

Protein	Function_ID	Function_description	E-value
NZ_AP012324.1\|WP_015439311.1\|2144776_2146195_-\|MFS-transporter	gnl\|CDD\|340890	cd17332, MFS_MelB_like, Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily. This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.54925e-45
NZ_AP012324.1\|WP_003829591.1\|2166772_2167486_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	4.67607e-50
NZ_AP012324.1\|WP_003829622.1\|2143096_2144116_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	8.88393e-106
NZ_AP012324.1\|WP_003829615.1\|2149210_2151079_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.52193e-142
NZ_AP012324.1\|WP_003829589.1\|2167557_2167935_+\|DUF4235-domain-containing-protein	gnl\|CDD\|379422	pfam14019, DUF4235, Protein of unknown function (DUF4235). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 88 and 119 amino acids in length.	4.09412e-11
NZ_AP012324.1\|WP_003829587.1\|2168030_2168798_+\|nitroreductase-family-protein	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	1.55485e-77
NZ_AP012324.1\|WP_003829585.1\|2168963_2171711_+\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	4.04757e-89
NZ_AP012324.1\|WP_080543815.1\|2152360_2152588_+\|DUF1684-domain-containing-protein	gnl\|CDD\|377941	pfam07920, DUF1684, Protein of unknown function (DUF1684). The sequences featured in this family are found in hypothetical archaeal and bacterial proteins of unknown function. The region in question is approximately 200 amino acids long.	1.71234e-24
NZ_AP012324.1\|WP_003829606.1\|2159452_2160925_+\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NZ_AP012324.1\|WP_003829607.1\|2158269_2158971_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	6.59092e-99
NZ_AP012324.1\|WP_032738281.1\|2147249_2149079_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.75794e-178
NZ_AP012324.1\|WP_172644904.1\|2154501_2158179_-\|ABC-transporter-permease	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	7.48732e-20
NZ_AP012324.1\|WP_003829604.1\|2160976_2161582_-\|DUF624-domain-containing-protein	gnl\|CDD\|377412	pfam04854, DUF624, Protein of unknown function, DUF624. This family includes several uncharacterized bacterial proteins.	1.29089e-07
NZ_AP012324.1\|WP_014484409.1\|2162574_2163429_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.2199e-52
NZ_AP012324.1\|WP_003829597.1\|2163799_2164816_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	7.7199e-77
NZ_AP012324.1\|WP_003829594.1\|2165023_2166370_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|379175	pfam13416, SBP_bac_8, Bacterial extracellular solute-binding protein. This family includes bacterial extracellular solute-binding proteins.	7.00175e-35
NZ_AP012324.1\|WP_003829614.1\|2151262_2151784_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.75867e-15
NZ_AP012324.1\|WP_014484406.1\|2152724_2154248_-\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	4.24587e-155
NZ_AP012324.1\|WP_003829602.1\|2161732_2162575_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.68174e-62
NZ_AP012324.1\|WP_003829619.1\|2146299_2147241_+\|FAD:protein-FMN-transferase	gnl\|CDD\|376782	pfam02424, ApbE, ApbE family. This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis. It acts as an FAD:protein FMN-transferase, catalyzing the attachment of an FMN residue to a threonine residue of a protein via a phosphoester bond in such bacterial flavoproteins.	2.68138e-23

>NZ_AP012324.1|WP_003829607.1|2158269_2158971_-|ABC-transporter-ATP-binding-protein
MAYIEFDKVVKEYPSGGTSIRALDEASFTADQGELTVILGQSGAGKTTALNILGGMDTATSGRVVVGERDITGLRKRDLITYRRNDVGFVFQFYNLVPNLTALENVELASQICPDHFDPAETLRKVGLGERMNNFPGQLSGGEQQRVSIARAIAKKPKLLLCDEPTGALDYETGKEVLQLLQDICRDEGMTVMIITHNSALAPMAHKVIHFRSGTVTSEEINTAPQPIADIEW
>NZ_AP012324.1|WP_172644904.1|2154501_2158179_-|ABC-transporter-permease
MKRPVKQSESDDRGSSVSAVFVKDALRCWLRSWKRFVSIAVITLLGVAVLTGIYAGCRDAFLAASRFYGQQGLHDVQVLSTYGLTSDDAAALRRVEGVETVQPERSQTVTATVKGTKKTVTMQEIGTEGLDQPYLQQGDMPSKAGEVAVTQQFLNDSGLEIGDDLTVTPRSASSTVLVGAEDKSNRGSSKSSDGDTGTVGAAEDATTSNNEKEQSPQFPTELTITAVVLDPSDLNNPAGYSGMTAFRSTSSEDYVFFAPSDGVTGNVYTAISIAVAGASQYDTFSDDYDAAIKTVADRIESQIQTQRQKARRQQIVTSAQNTLDAAKADALKQLDEGQQQIDSNRAELEANETKLAESRTQLEQNKASITDGERQIAEGRAQIASARQQIAQGRQQIADARAQLESGKAQLTSARQQLDAAQAELTANRSKVEQGIAQIDQGVAQLDQMLQLIQQADDLLSQLDPNIDIDSSTWQTVKQLLTSLGITVPDVPSISSLRQQLDAKQNELQSQRSDAIKKKTELQQTLDGTIAPAQNTLDQQNAQLTAKEQEAAAGEAELNAKLAELESNAAQLETRSAQLEAQAAQLAGGKQQLEEGEKQLKDGEQQLEDGKQQLEDAQQELDEKRSEAESEFAKQQRCIDDVANARWYVQTRSSIDGFSSLKSDVSSIESIGRAFPVVFLLVAVLMSLTTMTRMVEEDRGLIGTYLGLGYGGMVVSLRYLLFALLACLVGGGIGLLVGFLGIPAFLLIVIKGLYILPDVRLEYDWGYGTAGILLFVVGVGVATALACRSEIRHTPAALMRPKAPKAGARILLERIRPVWNRLSFLGKVTARNIFRFKSRLLMTVGGVAGCTALIICGFAINDTVDTIGVKQYGQIYQYDLMVVSNDDDAAVMRKQVKKDGRTTETLNLRVDSAEMSNAAQESETIQLMAVPNNSLNKLNDMVTLEEAGDEGWFGLPNFFGASGGGTVTLDDSGVIVAQSAANSLGVHAGDTVTVSNGGSSRAKIKVAAVVRSLIGSDVYISERLYDQKFAAHDIDSSASDGESSTLTWNAMLAKLKGPDGEQAEYADRLGEESSVVKAVSCAHLEATFKFDLMAAVVALIVGLAGGLALVVLFTLANTNVSERVREMATLKVLGFYDREVHNYVNREMMILTGMGVVVGLPLGRWIGGLLTAALNMPSLYFEVEVHWYSYAIAVAVTLAFALLVQLFTNPVLDRIEPVSSLKSVE
>NZ_AP012324.1|WP_014484406.1|2152724_2154248_-|amino-acid-permease
MADTNANGNAQQSGSKLKSVESLDQTNAMERGLSNRHVQFIAIGGTIGTGLFLGSGKSISLTGPSIVFVYILVGVIMFFLMRAIGEMMYRDPSQHTFINFITRYLGNGWGHFAGWTYWAALVLLGMTEITAVSTYFITFFDTFGIDLTHWKWLIELCFLVSLVSVNLIAVKVFGEVEFWFSMIKITLIGAMIVTAVVMIVIGYQYPAARIHGVDHVSPAGHAGLDNLFAGFSFAPNGWMAFLMSFQMVFFAYELLEFVGVTVSETKNPREVLPKAVNEIIVRVLIFYVGALVAIMCIVPWTSFKPNEDGSFASPFIMVFQYAGLNWASALVFFVVITAASSSLNSLLYSAGRHLYQLAEESPSPMLNKIGQVSDRKVPARAILVSAVLILLSPIVNAIPGVSGAFVLFSSASSAVFLFIYILTLVAHRKYRRSDDFIPDGFVMPVWKVLNTVAIAFFVFIYLTLFLADDTRNSAIAGLVWLIGFGGFSLLRERYRSRDLKAALEHKE
>NZ_AP012324.1|WP_080543815.1|2152360_2152588_+|DUF1684-domain-containing-protein
MFFSDETSGTETAGIGRIYELTAADILTLDHIDFNYAFNYPCAFSLFCTCPIPSKRNHLPFAVTAGEKTPKEYQY
>NZ_AP012324.1|WP_003829614.1|2151262_2151784_-|MarR-family-transcriptional-regulator
MGFEQEAVGELYASVWGNRSKMQREFTRGAHGEQFVLRELSFKGTQTPSQLATALQASSGRISTVLSSLEKKGWITRDIDSNDRRIIRVSLTDSGREESRRMIDEMRSAICWIFSQMGERRTREFVDLLSEFTTYMSICHPGQPRPTPEQVRGAFAERDKRVAEHMAAKHAEG
>NZ_AP012324.1|WP_003829615.1|2149210_2151079_-|ABC-transporter-ATP-binding-protein
MFRIMKYLSKAEIGQMLIALVSIVGQIWFDLELPDYMSDITTLVETPGSAMADIWVAGGKMLLVSLGSVCCAIITGYIAARVASSFGQRLRSLEFRKVESFGPAEMSKFSTASLITRSTNDITQIQMFITMGLQLIVKSPIMAVWAVCKIAGEGFEWTVATAIAVVILLVAVVILMALVMPKFKAMQRLTDNINLVARENLTGLRVVRAYNAEDYQESKFTKANKDLTDTQLFTNRTMAIMMPLMNTVMNGLMLAVYWIGAYLIEAAELTDKLTVFSNMVVFSSYSVQVIMSFLLMSMVFVLWPRADVSAQRVMEVLNTEPIVKNGTKRAADIAKTGQTGTVEFKNVSFTYPDSREAMLQDINFKAEKGQTVAFIGSTGSGKSSLINLVPRFYDVSAGQVLVDGVDVRDYDMVALRDKIGYVPQRSVLFKGTVAGNISYGDKPGENDAVELADTSTSAGRKREALQLATDAANDGKLTDEQMSRVKAAADVAQASEFVNRMDGGFDSPIAQGGSNVSGGQKQRLSIARAVYRHPEILIFDDSFSALDFKTDRAVRDALAKEAKDSTKLIVAQRIGTIMNADRIVVLDEGKVVGQGTHRELLENCEVYRQIAESQLSESELTA
>NZ_AP012324.1|WP_032738281.1|2147249_2149079_-|ABC-transporter-ATP-binding-protein
MPRGPMGRGGAVEKPQDFGKVMGKLVRFCRKYVPAIIIALVLGAAGTICQIIGPDKLKDMTNEITKGLPAVVHGKPVLNSIDMGAVARIGWLLVVLYVGYALLSYIQSWMMATVTQRTAQELRESISKKINKLPLSYFDKVSYGDVLSRITNDVDAIGQTLGQSLGSLITSATLFVGALVMMFYNNWIMALCAIGSSIIGLIIMMVIMKASQKYFTRQQVALGDVNGHVEEMYAGHTIVKAYNGEADSIRRFERYNADLYDSGWKSQFLSGLMMPLMNFVGNFGYVVVCVVGAALAMDGQIEFGVIVAFMMYIRLFTQPLSQFAQAFQNLQRCAAASERVFGFLEESEMADESGKQVLLGAQGHEVHGDVEFSHVRFEYEAGKPIINDFSASVSSGQKVAIVGPTGAGKTTMVNLLMRFYEIAGGSIAIDGVDTKSVPRWNVHDQFSMVLQDTWIFNDTVRENIAYSKPGVTDEQIISACKAVGLHHYIMSLPNGYDTVLDENSSLSAGQKQLLTIARAMVQDAPILILDEATSSVDTRTEELIQKAMDALTVDRTSFVIAHRLSTIRDADMILVMNHGDVIERGTHEELLAAGGFYADLYNSQFALAG
>NZ_AP012324.1|WP_003829619.1|2146299_2147241_+|FAD:protein-FMN-transferase
MTGLTEQLPHTAAFPNALGTGLLLHTASALGGDLHQHIEDLISDYENVLSRFKGDSIVGQMRVATHGGTFDFPDWTLNLFDLYDHLFSATNGAIDPCVGEDLIRLGYDKSYSSVNEPNADEHTGAIHGRATWDHAIEHHGTTLVTHGPVALDFGACGKGYLVDLIAERLGVAQSDLRYVIDAGGDLLVHTSEPITIALEDPSDPANAVGVAEISQGAFCASSPSRRHWTDAAGHQLHHLLNAIDGVPVNSVAATWVAATPPSLATAQADGLATALFTSPAAQLRAHFPFECAILTADRSAAQSPDFPGSFFMR
>NZ_AP012324.1|WP_015439311.1|2144776_2146195_-|MFS-transporter
MDNATAVSATNVSGGSLQSTIKDLPIAKVWAFAVGQFGWALLSGIISNWLVYFYQPDQETISQGQTVFVPQGLVVLGLVTVVGGITAFARFFDAFVDPAVASLSDRCDSKAGRRMPFLKFAALPLAVVTVLVFWSPINGTSWVNAAFLFVTVIGYYIALTFYCTPYNALIAELGHDSKQQLTISTAISFTWVAGTAIAYVAPVIWGAFVPMMGRITAIRVTFTIMAAVAFACMLVPPLAIREKDYVNSQPTSESTIESLKQTFSDGEFRKFVCSDVVYWVAITTFQTGLPFFVTSLLKLPETTTTIYFVLMTGVSVLFYLPVNILANRVGKKRLLLIAFVIFTCAFAFAGALGSGVLALMPAMAQGLTLSVVGAIPMAAFGILPQAIVANIADASSKTTGQDRQGMFYAARTFAMKMGQSVAMLLFTGVSTIGMASGAGYRIAAVCAAVLCGLGGIVFAFYNEKKVLHVLGA
>NZ_AP012324.1|WP_003829622.1|2143096_2144116_-|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MTSADELNEQRDAEQSVAQVFERNDGNDGIDAGGPAASQTRESAVTIPAGTVVLAATPIGNVGDASARLVAFLERADIVAAEDTRRLFDLARRLGVYVNGRVVAYHDHNERDKADGLLDQVETGATVLVVSDAGMPTINDPGLAIVRRAIERGLPVTCAPGPSAVLDALALSGLPTDRFCYEGFLPRKHAERVQYLRTLLGERRTIVFYETPHRIADSMDDLLDAFGPNRPMALCRELTKDYEQIRRGPIGEIRQSVIDDPPRGEMVLVIGGASSEEAEAAAPSTLSVEDMAVLAIDRALEDGLRIKDAIAQVVQEHPLADGSLANRKQVYAAVLEIKG
>NZ_AP012324.1|WP_003829606.1|2159452_2160925_+|amino-acid-permease
MSTTDAPKKPRETDDVPVPATLRKSLKNRHIQLIALGGAIGTGLFYGSSESIALAGPSILLAYLIGGFAIFMIVRALSEMSVEDPKAGAFSYYATRYWSKRAGFISGWNYWFNYILVSMVELAVVGSFVNYWFPAIPTWVSAAVFLVLITAANLLGVSKFGEFEFWFAIIKIVAVIAMIIGGLAVIIFALPTASGIKASFANWFTVGGGFFPNGLMGHTDNGWTGLLMALVVVMFSFGGTELIGITAGETEDPRTTIPRATNDIIWRILVFYIGALGVIMAVVPWNTIDGKSSPFVQIFDSVGIHAAAGILNFVCLTAVMSVYNSGLYANSRMLYSLAKQGNAPAYLGKLNSKGVPVAGVLTSAVITAIAVVVVFVWPEFAFNYLMSIATIAGIINWTMIMFTEMKFRKVVEAGGAPEDSNLAGKSGQEALDAIHFKLPFAKVTPWVVLVFLALVVVLMCFSASYRIAVIAGVIWLAILFVAYQITQAKK
>NZ_AP012324.1|WP_003829604.1|2160976_2161582_-|DUF624-domain-containing-protein
MNWLAPDSKFMRAWSNLIDGVWVNILMLVTSIPIITIGAALTAGHDACRRSIEGEGKGVTANYFRSFKANFVKATLLWLPFLVVLIALAWSWIVLQFTPLLIIKFALTIIWLIGFEWVFALQARFENTVAGTLKNAFIFGISHIAMTAALVVVDAVFVALLVGSWFYMPGGLFLLVILGYGTMLMLHIPVTERVFKPYLQQ
>NZ_AP012324.1|WP_003829602.1|2161732_2162575_-|carbohydrate-ABC-transporter-permease
MNENKPVKHGALWTVLFAVVSLFWIFPIVLVLINSFKQKAYISKNAFSLPAGKAFVGFENYVRGVETTQFFASFGWTLLITVGSVILILVCTSMCAWWIVRVNNWAAKLLYTLFLFNMIVPFQMVMFTLSKIADMLKLNTPWGLCIVYLGFGAGLAVFIFTGVIKGIPAELEESAMIDGASVPRIFFQIVVPIMKPSIVSVAILEAMWIWNDYLLPYLTLDLGKYKTISVAVQYLKGGYGSVDMGAMMACLVLAIIPIIVFYLVCQKYIVSGVMAGAVKG
>NZ_AP012324.1|WP_014484409.1|2162574_2163429_-|sugar-ABC-transporter-permease
MISMAGKAIRRWWALFALPTFAAFIIGFLVPFIMGVYLSFCEFTTVTDGEWIGLKNYTKALKDKEFLHALGFSTAFTIVTTIVINVIAFAIAYMLTKAIKGSTLFRSVFFMPNLIGGIILGYIWLLLLNGVLAHWGRALTYKASYGFWGLVILVCWQQIGYMMIIYIAGLQALPTDVLEAAAVDGANGRQTMFRIIIPLMMPSITVCSFLTVTNGFKLYDQNLALTNGAPSNMSEGLALNITRTFYGRMGWEGVGQAKAVLFFILVAVIALIQNKLTTSKEVAA
>NZ_AP012324.1|WP_003829597.1|2163799_2164816_+|LacI-family-DNA-binding-transcriptional-regulator
MTTSIQDVAQKAGVSISTVSRSFTRPDLVSTKTRERVLAIADELNFSLFRSAAALKSGRSLRIAVLMSGHIRLWFTASVIEGLNEVLHAAGYDISVFQISSIEERREFFEMLPVRRNADAVIVVSFDIDNNEITQLASADVPIIGINSVDPEVRGFTAAVNINDVQGSTLAARHLINLGHRDIAYISTDRDVSLNFSVQNRFGAFTECCRNEGIEPQVIVCKVDDAGRYQISDVVTQLMSLPKLPTAIACQEDGIALPLMFQLERNGLSVPGDVSLIGYDDSFYTDDIGLTTIRQNPVGMARKAAHMTLDLIEEKPVDEPYVVAPAHLVVRSSTAKIR
>NZ_AP012324.1|WP_003829594.1|2165023_2166370_-|ABC-transporter-substrate-binding-protein
MKEKGSMMNRTVKSAVAVAAIAAMSLGTLAACGSSTSGDDSKGKVYYLNFKPEAADQWAALAKEYTKEKGVEVKVQTAASGTYEQTLKSEIAKTEAPTLFQVNGPVGYQNWKKYTADMSKTDVYKELTNQDVALKDGDKVVGVPYVMETYGLIYNKDILNKYFALDGAKATSMDEIDNFDTLKAVADDMQSRKDELGIKGAFTSAGFDSSSDWRFKTHLANLPLYYEFKDDNVTEQPAKIKGTYLPNYKKIFDLYITDSTTEPTQLSAKTGDDANSEFALGEAAFYQNGTWAWTDLQKAGMKAESVGMMPIYIGVKGEEKQGLATGSENYWCINDKASDADKKATEDFLSWVITSDAGKKALSQDMGFTTPFKTFDDVKSDNPLTEAAVEDQKSGKTQVSWNFTMMPSEEWKNKIGQALLEYAQGTGNWDAVKATFVDGWASEYEASH
>NZ_AP012324.1|WP_003829591.1|2166772_2167486_-|histidine-phosphatase-family-protein
MSEQHMDGTVAVDASCGKAGFLVLLRHGQTFWSESGQHTGRTNIPLTEVGRQQAMDAGARLREAFPEGFDPECVFSSPLKRACQTAELAGFAQHGILDGIAEWDYGRAEGRTRQQVSEASGFSWDVWRDGPRSLTPTLEGDWVDTLPDGEQVNVHSGAGETLDEVAARARTAIEEVTPLLQSGRNVLLVAHAHILRILTSQWLNVDPQFARLLRLDTAHYSVLSVYKGDNVIERWNA
>NZ_AP012324.1|WP_003829589.1|2167557_2167935_+|DUF4235-domain-containing-protein
MSDETSTGIASDADRVVEGLHRIDQKVDDLRNQRLNDPDSLGDKLVKSAVPALAGLVAGKLFQIAWDKGAARRNVIKGLAADAPQGLAMSLAFAAISAAFGAIVSQLSNQGSQAFVERRHRKASR
>NZ_AP012324.1|WP_003829587.1|2168030_2168798_+|nitroreductase-family-protein
MATNATIETLLNRRSIRKFKDEPIDDDATATLETVAQHAASSQFLNDWSAIRVSDPAIKARLAEIGNQPYIATAPLLYVFVIDEHRNAHIAQRKGIDPTSDEFHLKYSYRFTQAQNDAVLALHAMETAAYSLGLGGVILGSLLNDIPALIDLLNLPEYTYPVLGLALGKPDQEPTLKPRMPRSMQFFDNTYPADDDGMLEQLPDFDNKVHQYYDLRQTDRPVDAFSDQIASVSRQGVSGKTLLDKAAAQGFQLDK
>NZ_AP012324.1|WP_003829585.1|2168963_2171711_+|YhgE/Pip-domain-containing-protein
MRTVWQVFLRDCKRILRNPVAAVVTLGVAVLPSLYAWFNILANWDPYSATGNLQVAVANEDRGTTNDLVGHLNAGKQVVIKLKHNDQLGWRFVSNEEQAVQGVQTGDYYAAIVLPKDFSASLVDSLTGTSKQPKIKYYVNEKKNAIAPKITDTGATTIDEQINSTFVTTVSNTVAAAISQAGDDLDQATNSTQNNVVADLGSVLSTIATVQDALTDLRTTLDQSDTALADARSTTASLQRSITAAQQASQQSGALLAETQDGSKVFAASLVSALDTSSAQLSGLTVNVNNAAGTINQSFNTAQNSVDTITNALNSPLDKTATSLDTLKDALNKAGISADTTDPTGKRIWDHINAIDDAISTQQAKINTFHEDTTRFIDSGKSATTNLSGAMSGTATGGIAALNTARSSLTGTVMPSLTSSLNSFAALNGTLNGTLTSLSGTLDQTNGLFDQLSSTIAQTRTTIGSAQDSLNQIIDDVSTVRTDVATLDSSAVYQKIRDTMHLDDKGFGEFMGSPVTLTTKVVYAIDNYGSAVTPFYTNLALWVGGFVLIAIYKLEVDRESIRRINAKQAYLGRWMLLVTIGFLQAIIATVGDLVLGIQCEHPLLFILAGIFCSFIYINIIYALAVAFRHIGKAIAVILVIVQIPGASGLYPIEMMPDFFRKLHPWLPFTYGINAMRGPIAGTYSNHYWLDMLHLFWYLPAALFVGLVVRRYAMNLNALFDRRLGDTDLMITEHNSMVNEQVSLASVFRTVSDSKELKAIITRRAHRFFARYPMMIVAGLALLTILPFVFLILLFVTQEKIAMLTSWILSIILIDAYLIVVEYTRESYAMQLGVSAMNADEFRDVMLNGYVWRRFRSHGRHEAASAESAVDTDPDIGEVTEQLTPFERTGSTDSSDSSKSSESTITDTNPAQGGAR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP012324_2	2.1\|2009010\|36\|NZ_AP012324\|CRISPRCasFinder	2009010-2009045	36	NZ_AP012324.1	2010347-2010382	1	0.972

1. spacer 2.1|2009010|36|NZ_AP012324|CRISPRCasFinder matches to position: 2010347-2010382, mismatch: 1, identity: 0.972

tcaaagccaatgacagatatttaggaaaccaacccc	CRISPR spacer
tcaaagccaatgacagatatttaggaaatcaacccc	Protospacer
****************************.*******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP012324_1	1.1\|1342477\|25\|NZ_AP012324\|PILER-CR	1342477-1342501	25	NZ_CP017943	Phyllobacterium zundukense strain Tri-48 plasmid unnamed2, complete sequence	439394-439418	4	0.84

1. spacer 1.1|1342477|25|NZ_AP012324|PILER-CR matches to NZ_CP017943 (Phyllobacterium zundukense strain Tri-48 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.84

ggtgcagctctcgcagtgctggagg	CRISPR spacer
tttgcagctctcgacgtgctggagg	Protospacer
  ***********  **********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1482331 : 1494343

Propionibacterium_phage(33.33%)

head,portal,protease,capsid

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003830546.1\|1482331_1485193_-	hypothetical protein	K4JW62	Streptococcus_phage	4.6e-56	57.7
WP_003830545.1\|1485227_1485554_-	hypothetical protein	NA	NA	NA	NA
WP_003830544.1\|1485550_1485973_-	hypothetical protein	NA	NA	NA	NA
WP_003830543.1\|1486073_1486349_-	hypothetical protein	NA	NA	NA	NA
WP_003830542.1\|1486345_1486945_-	hypothetical protein	NA	NA	NA	NA
WP_003830541.1\|1486958_1487390_-	hypothetical protein	NA	NA	NA	NA
WP_003830540.1\|1487389_1487677_-	HK97 gp10 family phage protein	A0A1P8VV83	Rathayibacter_phage	6.0e-17	48.9
WP_003830539.1\|1487681_1488080_-	hypothetical protein	A6N202	Microbacterium_phage	3.1e-11	39.6
WP_003830538.1\|1488076_1488595_-	hypothetical protein	A0A1D8ETD3	Propionibacterium_phage	6.9e-11	31.1
WP_019727447.1\|1488609_1488957_-	hypothetical protein	NA	NA	NA	NA
WP_003830536.1\|1488965_1490168_-\|capsid	phage major capsid protein	A0A1D8ETI2	Propionibacterium_phage	1.4e-112	52.7
WP_003830535.1\|1490182_1490929_-\|head,protease	HK97 family phage prohead protease	A0A0E3XB56	Gordonia_phage	3.1e-28	38.5
WP_003830534.1\|1490925_1492332_-\|portal	phage portal protein	A0A222ZFM5	Arthrobacter_phage	6.1e-46	34.5
WP_003830533.1\|1492353_1493967_-	hypothetical protein	A0A1D8ETA8	Propionibacterium_phage	6.6e-137	52.1
WP_003830532.1\|1493980_1494343_-	hypothetical protein	A6N1Z4	Microbacterium_phage	2.9e-08	40.5

DBSCAN-SWA_2

1497883 : 1506797

Lactococcus_phage(12.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_100198996.1\|1497883_1498294_-	adenine methyltransferase	A0A126HBP0	Lactococcus_phage	4.1e-35	51.6
WP_003830514.1\|1498373_1498550_-	hypothetical protein	NA	NA	NA	NA
WP_003830512.1\|1498546_1498876_-	hypothetical protein	NA	NA	NA	NA
WP_003830510.1\|1498872_1499154_-	hypothetical protein	NA	NA	NA	NA
WP_003830508.1\|1499150_1499348_-	hypothetical protein	NA	NA	NA	NA
WP_003830506.1\|1499344_1499848_-	hypothetical protein	NA	NA	NA	NA
WP_003830503.1\|1499850_1500243_-	hypothetical protein	NA	NA	NA	NA
WP_003830498.1\|1500372_1500873_-	single-stranded DNA-binding protein	A6N1Y1	Microbacterium_phage	1.2e-41	63.0
WP_003830496.1\|1500872_1501043_-	hypothetical protein	NA	NA	NA	NA
WP_003830494.1\|1501042_1501888_-	recombinase RecT	Q858E1	Salmonella_phage	7.9e-49	48.3
WP_003830492.1\|1501890_1502853_-	YqaJ viral recombinase family protein	I4AZN3	Saccharomonospora_phage	1.3e-23	27.8
WP_003830490.1\|1502849_1503008_-	hypothetical protein	NA	NA	NA	NA
WP_003830489.1\|1503004_1503652_-	hypothetical protein	NA	NA	NA	NA
WP_003830487.1\|1503823_1504045_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_003830486.1\|1504037_1504817_-	phage antirepressor Ant	I3NLD0	Bifidobacterium_phage	9.4e-105	73.6
WP_157960032.1\|1504813_1505461_-	DNA cytosine methyltransferase	A0A2I7RFJ9	Vibrio_phage	3.2e-26	34.1
WP_170163973.1\|1505393_1505900_-	DNA cytosine methyltransferase	Q6V7R9	Burkholderia_virus	5.3e-32	51.4
WP_003830479.1\|1506108_1506318_-	hypothetical protein	NA	NA	NA	NA
WP_019727444.1\|1506314_1506797_-	class I SAM-dependent methyltransferase	A8ATY8	Listeria_phage	1.7e-48	57.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP012324

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection