CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NZ_CP011936	Leptospira interrogans serovar Manilae strain UP-MMC-NIID HP plasmid pLIMHP1, complete sequence	0 crisprs	NA	0	0	1
NZ_CP011934	Leptospira interrogans serovar Manilae strain UP-MMC-NIID HP chromosome 1, complete sequence	8 crisprs	Cas9_archaeal,cas2,cas7,cas8c,cas5,cas3,WYL,csa3,DinG	3	1	3
NZ_CP011935	Leptospira interrogans serovar Manilae strain UP-MMC-NIID HP chromosome 2, complete sequence	0 crisprs	csa3	0	0	1

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

22269 : 60043

Leptospira_phage(62.5%)

integrase,transposase

attL 21138:21156|attR 46087:46105

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
21138:21156	attL	NA	NA	NA	NA
WP_100220184.1\|22269_22572_+\|integrase	integrase core domain protein	NA	NA	NA	NA
WP_000447737.1\|23226_23439_+	hypothetical protein	NA	NA	NA	NA
WP_000402983.1\|23487_23910_+	hypothetical protein	NA	NA	NA	NA
WP_000443825.1\|24257_24494_+	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
WP_000240418.1\|24487_24829_+	endoribonuclease MazF	A9D9Y1	Lactobacillus_prophage	1.8e-07	37.1
WP_000557895.1\|25192_25426_+	hypothetical protein	NA	NA	NA	NA
WP_144414599.1\|25696_26844_-\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	6.3e-41	34.5
WP_000708295.1\|26885_27473_-	hypothetical protein	NA	NA	NA	NA
WP_000793447.1\|27638_27824_-	hypothetical protein	NA	NA	NA	NA
WP_000457405.1\|27835_28300_-	hypothetical protein	NA	NA	NA	NA
WP_144414600.1\|28314_29447_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	6.3e-41	37.0
WP_000413569.1\|30077_30998_+	DUF2971 domain-containing protein	NA	NA	NA	NA
WP_000587204.1\|31260_32187_+	hypothetical protein	NA	NA	NA	NA
WP_000811792.1\|32726_33188_+	hypothetical protein	NA	NA	NA	NA
WP_000851075.1\|33294_33906_+	hypothetical protein	NA	NA	NA	NA
WP_020783218.1\|34565_35468_-\|transposase	Rpn family recombination-promoting nuclease/putative transposase	S5VY82	Leptospira_phage	1.1e-144	87.0
WP_100220180.1\|35843_35993_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_000161325.1\|36214_37249_+	DUF4917 family protein	NA	NA	NA	NA
WP_158423348.1\|37293_37497_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_000835630.1\|37698_37998_+	hypothetical protein	NA	NA	NA	NA
WP_001240337.1\|38000_38447_+	PIN domain-containing protein	NA	NA	NA	NA
WP_002156492.1\|38722_39046_+	hypothetical protein	NA	NA	NA	NA
WP_000562222.1\|39524_39827_+	nucleotidyltransferase	NA	NA	NA	NA
WP_000833996.1\|39816_40056_+	hypothetical protein	NA	NA	NA	NA
WP_000445079.1\|40387_40834_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_001058387.1\|41560_42082_+	hypothetical protein	NA	NA	NA	NA
WP_000830370.1\|42133_42397_+	hypothetical protein	S5VKH6	Leptospira_phage	3.4e-14	81.2
WP_048657724.1\|42929_43832_-\|transposase	Rpn family recombination-promoting nuclease/putative transposase	S5VY82	Leptospira_phage	2.5e-149	90.3
WP_001228551.1\|44943_45591_+	hypothetical protein	NA	NA	NA	NA
WP_000372799.1\|46281_46512_+	hypothetical protein	NA	NA	NA	NA
46087:46105	attR	NA	NA	NA	NA
WP_000878569.1\|47266_47740_+	hypothetical protein	NA	NA	NA	NA
WP_000624759.1\|47847_48108_+	ribbon-helix-helix protein, CopG family	NA	NA	NA	NA
WP_001181767.1\|48085_48502_+	PIN domain-containing protein	NA	NA	NA	NA
WP_000795145.1\|48676_49093_+	hypothetical protein	NA	NA	NA	NA
WP_000263416.1\|49835_49973_-	ankyrin repeat domain-containing protein	NA	NA	NA	NA
WP_000460629.1\|50192_50741_+	serine acetyltransferase	NA	NA	NA	NA
WP_001085030.1\|51213_52158_+	DUF2971 domain-containing protein	NA	NA	NA	NA
WP_000058748.1\|52346_53273_+	hypothetical protein	NA	NA	NA	NA
WP_025176343.1\|53542_55078_-	hypothetical protein	NA	NA	NA	NA
WP_000490310.1\|55226_55637_-	hypothetical protein	S5VXZ8	Leptospira_phage	3.5e-18	82.1
WP_000041754.1\|56092_56986_-\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_017853078.1\|59152_60043_-\|transposase	Rpn family recombination-promoting nuclease/putative transposase	S5VY82	Leptospira_phage	1.6e-145	88.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP011934

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP011934_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011934_1

793171-793273

Orphan

Consensus_repeat	Method
CTCAATGCATCGCTTTTATGGTCGCTCTGCAGGTCGGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011934_1

>merge|NZ_CP011934|1|793171-793273|CRISPRCasFinder
CTCAATGCATCGCTTTTATGGTCGCTCTGCAGGTCGGTGGAAACTCAGCAAACACCTCCCTAAACTCAATGCATCGCTTCTATGGTCGCTCTGCAGGTCGGTG

>NZ_CP011934|1|1|793171-793273|CRISPRCasFinder
CTCAATGCATCGCTTTTATGGTCGCTCTGCAGGTCGGTG	GAAACTCAGCAAACACCTCCCTAAA
CTCAATGCATCGCTTCTATGGTCGCTCTGCAGGTCGGTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011934.1\|WP_000575927.1\|790072_790318_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_033109365.1\|787708_789628_-\|DUF1561-domain-containing-protein	unknown	unknown	gnl\|CDD\|284921
NZ_CP011934.1\|WP_000999362.1\|798589_798910_-\|TM2-domain-containing-protein	unknown	unknown	gnl\|CDD\|377473
NZ_CP011934.1\|WP_000135260.1\|784296_784920_+\|30S-ribosomal-protein-S4	unknown	unknown	gnl\|CDD\|235411
NZ_CP011934.1\|WP_010679757.1\|802867_803692_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349977
NZ_CP011934.1\|WP_000680452.1\|800483_801527_+\|hydrolase	unknown	unknown	gnl\|CDD\|293841
NZ_CP011934.1\|WP_000844810.1\|803688_804636_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|224017
NZ_CP011934.1\|WP_000706052.1\|801746_802871_-\|arabinose-kinase	unknown	unknown	gnl\|CDD\|224732
NZ_CP011934.1\|WP_001040194.1\|783150_783369_+\|translation-initiation-factor-IF-1	unknown	unknown	gnl\|CDD\|178954
NZ_CP011934.1\|WP_002156540.1\|795816_796743_-\|aspartate-carbamoyltransferase	unknown	unknown	gnl\|CDD\|234849
NZ_CP011934.1\|WP_001042618.1\|785921_786437_+\|50S-ribosomal-protein-L17	unknown	unknown	gnl\|CDD\|235522
NZ_CP011934.1\|WP_000752685.1\|783874_784285_+\|30S-ribosomal-protein-S11	unknown	unknown	gnl\|CDD\|180007
NZ_CP011934.1\|WP_000054108.1\|784942_785920_+\|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl\|CDD\|235359
NZ_CP011934.1\|WP_000440098.1\|795445_795811_-\|DUF2203-domain-containing-protein	unknown	unknown	gnl\|CDD\|378330
NZ_CP011934.1\|WP_002156541.1\|798220_798529_-\|DUF2752-domain-containing-protein	unknown	unknown	gnl\|CDD\|378499
NZ_CP011934.1\|WP_000075937.1\|796779_797874_-\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|366126
NZ_CP011934.1\|WP_000868428.1\|783377_783491_+\|50S-ribosomal-protein-L36	unknown	unknown	gnl\|CDD\|179039
NZ_CP011934.1\|WP_001284169.1\|794235_795462_-\|LL-diaminopimelate-aminotransferase	unknown	unknown	gnl\|CDD\|181053
NZ_CP011934.1\|WP_000428417.1\|791655_792801_-\|DUF5009-domain-containing-protein	unknown	unknown	gnl\|CDD\|226749
NZ_CP011934.1\|WP_000090770.1\|783494_783872_+\|30S-ribosomal-protein-S13	unknown	unknown	gnl\|CDD\|235358

Protein	Function_ID	Function_description	E-value
NZ_CP011934.1\|WP_033109365.1\|787708_789628_-\|DUF1561-domain-containing-protein	gnl\|CDD\|284921	pfam07598, DUF1561, Protein of unknown function (DUF1561). A family of paralogous proteins in Leptospira interrogans.	0
NZ_CP011934.1\|WP_000999362.1\|798589_798910_-\|TM2-domain-containing-protein	gnl\|CDD\|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	2.19124e-18
NZ_CP011934.1\|WP_000135260.1\|784296_784920_+\|30S-ribosomal-protein-S4	gnl\|CDD\|235411	PRK05327, rpsD, 30S ribosomal protein S4; Validated.	3.4174e-111
NZ_CP011934.1\|WP_010679757.1\|802867_803692_-\|RNA-methyltransferase	gnl\|CDD\|349977	cd18104, SpoU-like_RNA-MTase, SAM-dependent RNA methylase related to SpoU-TrmH. RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	2.49036e-80
NZ_CP011934.1\|WP_000680452.1\|800483_801527_+\|hydrolase	gnl\|CDD\|293841	cd16283, RomA-like_MBL-fold, Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain. Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.42767e-56
NZ_CP011934.1\|WP_000844810.1\|803688_804636_-\|SAM-dependent-methyltransferase	gnl\|CDD\|224017	COG1092, COG1092, Predicted SAM-dependent methyltransferases [General function prediction only].	1.26426e-36
NZ_CP011934.1\|WP_000706052.1\|801746_802871_-\|arabinose-kinase	gnl\|CDD\|224732	COG1819, COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms].	7.3666e-06
NZ_CP011934.1\|WP_001040194.1\|783150_783369_+\|translation-initiation-factor-IF-1	gnl\|CDD\|178954	PRK00276, infA, translation initiation factor IF-1; Validated.	7.21048e-51
NZ_CP011934.1\|WP_002156540.1\|795816_796743_-\|aspartate-carbamoyltransferase	gnl\|CDD\|234849	PRK00856, pyrB, aspartate carbamoyltransferase catalytic subunit.	2.03573e-131
NZ_CP011934.1\|WP_001042618.1\|785921_786437_+\|50S-ribosomal-protein-L17	gnl\|CDD\|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	7.63241e-45
NZ_CP011934.1\|WP_000752685.1\|783874_784285_+\|30S-ribosomal-protein-S11	gnl\|CDD\|180007	PRK05309, PRK05309, 30S ribosomal protein S11; Validated.	2.46344e-75
NZ_CP011934.1\|WP_000054108.1\|784942_785920_+\|DNA-directed-RNA-polymerase-subunit-alpha	gnl\|CDD\|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	8.52613e-166
NZ_CP011934.1\|WP_000440098.1\|795445_795811_-\|DUF2203-domain-containing-protein	gnl\|CDD\|378330	pfam09969, DUF2203, Uncharacterized conserved protein (DUF2203). This domain, found in various hypothetical bacterial proteins, has no known function.	1.90714e-28
NZ_CP011934.1\|WP_002156541.1\|798220_798529_-\|DUF2752-domain-containing-protein	gnl\|CDD\|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	1.06564e-09
NZ_CP011934.1\|WP_000075937.1\|796779_797874_-\|fatty-acid-desaturase	gnl\|CDD\|366126	pfam00487, FA_desaturase, Fatty acid desaturase.	4.26816e-21
NZ_CP011934.1\|WP_000868428.1\|783377_783491_+\|50S-ribosomal-protein-L36	gnl\|CDD\|179039	PRK00465, rpmJ, 50S ribosomal protein L36; Reviewed.	4.38154e-11
NZ_CP011934.1\|WP_001284169.1\|794235_795462_-\|LL-diaminopimelate-aminotransferase	gnl\|CDD\|181053	PRK07590, PRK07590, L,L-diaminopimelate aminotransferase; Validated.	0
NZ_CP011934.1\|WP_000428417.1\|791655_792801_-\|DUF5009-domain-containing-protein	gnl\|CDD\|226749	COG4299, COG4299, Uncharacterized protein conserved in bacteria [Function unknown].	6.97638e-56
NZ_CP011934.1\|WP_000090770.1\|783494_783872_+\|30S-ribosomal-protein-S13	gnl\|CDD\|235358	PRK05179, rpsM, 30S ribosomal protein S13; Validated.	2.98322e-75

>NZ_CP011934.1|WP_000428417.1|791655_792801_-|DUF5009-domain-containing-protein
MENKLNRNRILSLDLFRGMTVAGMILVNNPGSWSFIYSPLKHARWNGCTPTDLVFPFFLFAVGISIHFSVYSKNKIYLSKTWLGICIRSITLILIGLFLNFFGEWSFSELRIPGVLQRIGFVYWVVASLYLILPKRTILISWIPILIVHTWILIQIPPPGESIVYLEPGKDIGAWIDRNVFGENHLWKFSKTWDPEGFFSGISSITTSLLGVFCGSILSSKTNETKKQILSIFGFGTLFVLVGLLWNQNLPMNKSLWTGSYVIYTAGLAFLSIGFFEFLNLLLQTKKWNRLRLETIFQPFLVFGKNAILVFVGSGLLARILNLWTIASGNGKSISIKTLFYSKLIFIGNSHLESLIYAIINLFFWWIILSILDKKKIYIKV
>NZ_CP011934.1|WP_000575927.1|790072_790318_-|hypothetical-protein
MIFFYSETIKAKMMNKFLIIFINSFLLKILDSLYTLRKNIVVMFNKEKFRNVTSWLELVEQIGFLYIPQYLFLCVKTKNII
>NZ_CP011934.1|WP_033109365.1|787708_789628_-|DUF1561-domain-containing-protein
MRHSIVFIVVLLVLVITSFEYGIDHTHIHASSKIEYLVIQKPTDPPKDKPIKVIVSDGGKFCYGPTFSGGESYIIIEQCWQMHVMNARYDVFQRISYNINNTWLCITAPEKVIKAEETWDYVHLRPCTINDPLQRWIIKDNSFWTANERYQLKDTNWYVYISKNSGDRYNHTLDSSMNDWVNTIATPGNISIQTSIAWDLQTTEGQERYFIRWEGSDKNTTPLYYNPENGHLAQYDPISGSLYCMYSNVGRYQWNWVTWALCSDAAISKDNPAFWNVFFETDQGGMITDYKGNLLRVTRYGSNWGVAYTAKPDFVKTDIKNSPTSLFVVDKSLLDWTRYTYSNLGKTNQYCPAGNKEKILHKRAKRTLPPDFQLTENWVRRLYAIATSTIPEAQSSGICGTCLLHSFQMLAELQEYHSQGPLQSGGYFFNTAPNTAPNTDPFISFRQRYPLLDMLLSDVPTVYSSAGRTTRQLGLVSARTVLPQYNWIASSEFITRSEIRSHITSLIASPSGSIWLAILRLRRTDGVSGWHAVPILRTSQGLVVIRTRASLTSLDNYRQSLTPTMDPDLVIDNYLERPDLSLERLTTIQLGEVYHNTFDFIISNRNCTGEGDDRRGTGEYPTSASVNQCSNRRSRCALQ
>NZ_CP011934.1|WP_001042618.1|785921_786437_+|50S-ribosomal-protein-L17
MNKRNKVKHLNRNKGHRDALINNMITSLFKYERIESTQAKLKVVRSHAEKLITRAKKNLVTDLKPEVQLHNKREVMKRIKDREVVVKLFEDIAKRFETKNGGYTRVLKLVNRISDNSEVGILELTSRKERSTLLKERIEKREIQTKAREEKRATRKSNSAPVNKETTSKKK
>NZ_CP011934.1|WP_000054108.1|784942_785920_+|DNA-directed-RNA-polymerase-subunit-alpha
MSLKSLLKGFKRPKKIEFNTEANTPNYGKFVAEPFERGFATTIGNSLRRTLMSSIEGAAISAIRIEGVNHEFSFIEGVAEDVTRIILNLKQVRIKYEPEEKDQSKIIHLELKGAGYFRAGDLAVDSSIEIMNPDLHIATLNEDANLVMDLEIQRGRGYVPAEEKKKDIEVLGTIPVDSIFSPVQKVVFEVSETRVAQRSDYEKLTLEVWTDGSVSPDDAVAQAAKILKEHLTVFINFEEELEEEDDELDEADEKLKASLSKHVEELELSVRSLNVLRSLEIDFIGDLVKRSEEEMSKSKHYSDQCLQELKVKLSTLGLSFGMRDF
>NZ_CP011934.1|WP_000135260.1|784296_784920_+|30S-ribosomal-protein-S4
MARYRGPVVKIMRREGVDLFLKSSYTFNKDKFHRKGPPGMPTKRKGKVSEYGAQLREKQKLKRAYGLLEKQFRRYYEEASHAHGVTGEILLQLLERRLDNVVYRLGFAITRRQARNFIAHRHILVNGERVDIPSYRLNVGDKVEIREKFKTSSFIADNIKLSQSLQGIPSWLSADYTNFGGDVTALPERHHIDLPVKEQVIVELYSK
>NZ_CP011934.1|WP_000752685.1|783874_784285_+|30S-ribosomal-protein-S11
MADDKKSAKKEKKVKKKEKKIVPRGKVYITASFNNTIVTITDMAGNTISWSTSGAMGFRGSKKSTPYAAQIAAGNAAEKAMDSAGLQEVDVMVSGPGIGRESAIRSLVARGLNIKMIKDVTPLPHNGCRPRKRRRV
>NZ_CP011934.1|WP_000090770.1|783494_783872_+|30S-ribosomal-protein-S13
MARIAGIDLPREKRIVVGLTYIFGIGNSLSRLILKKAGIDESIRVKDLNESQEAAIRKTLEETAKVEGDLRSEIQLNIKRLMDIGCYRGLRHRRGLPVNGQRTRTNARTRKGGKKTVANKKKVTK
>NZ_CP011934.1|WP_000868428.1|783377_783491_+|50S-ribosomal-protein-L36
MKVRTSVKKICSSCKVIRRKGVIRVICTNPKHKQRQA
>NZ_CP011934.1|WP_001040194.1|783150_783369_+|translation-initiation-factor-IF-1
MAKEEAITVDGTVLEPLPNAMFRVELENGHKVLAHISGKMRMHYIRILPGDKVTVELSPYDLSKGRITYRKK
>NZ_CP011934.1|WP_001284169.1|794235_795462_-|LL-diaminopimelate-aminotransferase
MANINENYLKLKAGYLFPEISKRVKIYSEKNPSAKIIRLGIGDVTLPIVPSVVDAMVEASKEMGTVGGFHGYGPEQGYSFLLKSIADHDYGSLGIKIDESEIFVSDGSKCDCGNIQEIFSTDSKIAVADPVYPVYVDTNVMAGRTGEIGPDGRYSNLIYMPATKENGFQPEIPKEKADIVYLCYPNNPTGTVTTKESLKAWVEYAKKNNSIILYDSAYEAFISEPGVPRSIYEVEGAKEVAIEFRSFSKTAGFTGLRCAYIVIPKELKGRTRSGEEVSLNSLWNRRHTTKFNGVSYVTQKGAEACYSPQGKKEIQTSIAYYMANASKIRDGLKKAGYEVFGGVNAPYIWLKTSDNLSSWDFFDKLLNKAQVVGTPGSGFGPAGEGYFRLSAFGKKEDVEEATARITSL
>NZ_CP011934.1|WP_000440098.1|795445_795811_-|DUF2203-domain-containing-protein
MERKLWTYQEARKILPIVKEITEKYYSYVSELAVQLRDKILPENEMENKEEEIRKLILEWSSKIQEFGIEVKGLWLIDFDNGNGYYCWHLGEEDLLYEHGYEEGFAGRKQIDKDQKDGEHQ
>NZ_CP011934.1|WP_002156540.1|795816_796743_-|aspartate-carbamoyltransferase
MHYNHKNVLDTEQFSKPDLDFLIGKIRIMERLVEQNKAFGILTGKLLASLFFEASTRTRLSFEAAMERLGGRVISTVGFQFSSISKGETLYDTMKMVEAYADIAVIRHPVEGSSRIAAGAVKIPVINAGDGAGQHPTQAILDLYTIISEKGTLDGLTVAFIGDLKYGRTIHSLINLLRHYKVRLFLISPPELALPESYKKALQGYSLTLEETTDIKAVWDCDVAYVTRIQEERFPDHKEYERLKDLFKVNKELILASKKETTVLHPLPRVNELSTDVDDLPNAAYFRQARYGVVSRMTLLCLSLGQDF
>NZ_CP011934.1|WP_000075937.1|796779_797874_-|fatty-acid-desaturase
MSQAPRRNLPEKTNRTIATLLCVFFISIYFWNLISIRSFNIFYTLDILDSVSNRTQTFSFLELLSHRFENRFQYDIPKWIYVLNIFKFIESFFIPVFLFLFSTIFSYTLWALIHECVHGNFSNSRNENRFWGRFLCILFGTPFQVVKTAHLVHHKFNRSQGERIEYIEKNAGPILFQKLLYYVRLFMGTYFLEVLGGFLLSLPLSFTSPITEKYFSKFPVYKTFFKQIQKPEIVQELRIDSVLILILFGCAFYLCGPNTVFLISVLILRGWIVSFLDHSYHYGKELEDVNSAYNLYLPKFFSYLFLNFNYHRVHHRFPGCSWNRLPIQFKNSNDSMDLSLWIQSIRQLSGLLILPEKSDPHKSI
>NZ_CP011934.1|WP_002156541.1|798220_798529_-|DUF2752-domain-containing-protein
MLKFPKKIKFAFVSFGAFIFYNIPTEYMTGRYTVCLFKLILERECIGCGTVRGFWCILHLQFEEAFRFNQTIFITFPLFIFCILYWTFNMDFRKLKRNLLGI
>NZ_CP011934.1|WP_000999362.1|798589_798910_-|TM2-domain-containing-protein
MNDNISKGMDEVFCSSCGSIIKKAAEICPKCGVRQKGSASDNWLITFLLCLFLGVLGVHRFYTGKIGTGILMLITGGGCGIWALIDLIMILLGNYKDSQGNPITRN
>NZ_CP011934.1|WP_000680452.1|800483_801527_+|hydrolase
MKHIFLFIILLFLFETCFPIDPERIRSSHFQDGKYHNIEEDVRLNKNFFSVLRWKILGPKDPPTVEGDLEKIPDVIPIKKEDLLAPEGKVRIVWLGHATVWIASNFHGKRMHILTDPIFTGVPPFVKRLTKLPIEPENLPGVDIIVISHAHRDHLDIDSIQKIQKLFPEVTVHLPSGMGEFARDEGLENAVIQEWWTITEYAGTKIHFLPAKHWSRMGLTDMNQYHWGSYAFEFENIRIYFGGDTGFSKHFSEIGKRFAQGFSATILPIGAFKPRWFMEPAHIGPKEALEASSILHSSLILPVHWGTFALGDDLPLEAPLYLKKLHSEKKDKLPALRVWTMGEIVDL
>NZ_CP011934.1|WP_000706052.1|801746_802871_-|arabinose-kinase
MKITYYVSGHGFGHISRSMEIILYLLRSFPDLTIDLVTVREKFLDTLFLSEEDTKNLRRLQIRKRSLDVGMIQKDSLSIDAVATEAAIEEFNLQKSYIQISEIESCLDFGTELIISDSASLPFKIADKLKIPSLFIGNFTWDFIYSGYAKESSIFEKATRSIYEEYYHATFGLLLPFNCPANSLAEQKQIGLVGRKPFLNKNEAKEFFKLPKDKIHLLFSFGAYGVETSRFDWEKFDPEKYTIVLSGTDFDLLKIPNKQKNGIIQLSNLHYPDLLTACDFVITKPGYGILSEAVYAKTPVLYTDRGNFPEVPYLHKSLTEEIPSSYISNEDLFLFRLDKPLQKANVWKGKSSTLFERDGREDVKHAVAVFLKLL
>NZ_CP011934.1|WP_010679757.1|802867_803692_-|RNA-methyltransferase
MNDIQFLEITSFSNEKLKTISNLKEKKHRETSGLFFIEGYREILRAQKSGKIKFQNILFSPECFLGENEFSLIRSIGTKNIKVPKKIFEKVSYRDRPDGLIATAFFFETGLDTFQNKSNIFKNLKPILVIEGVEKPGNLGTILRTAEGAGFHTVLVADPKLDLFNPNVIRASTGALFTLEVYLGEIKLIYEILKKNQYRTLAVTPEATKHYYNVDLKGKIALVFGSEQYGLSTYARNNSDEYVSLPMFGESDSLNLAMSAGIVMYEVIRQVSVL
>NZ_CP011934.1|WP_000844810.1|803688_804636_-|SAM-dependent-methyltransferase
MKTAKKIESSKTNSQKKSISVERFSETNPKVIETGSYKLIDSGNFRKLEQIGPYTIIRPSPVSAWPVTKPNLWNNVYGEYVRSDKGGGSWDWHKKTEEEFYIRILEYSIKIKFTPFGHLGIFAEQLENWKKIRKLSSQLKKEDEVLNLFAYSGISTLAVLDGGASVCHLDSSKGMVDWARDNANASGLAHKKVRWMVEDVLKFLKREIKRGKDYRGFILDPPTFGRGASGEVFKIEKDLPELMDLLMELSGNKPDFIVLTCHSTGFSPLALQRILDGRINNKGSFHIGELSIPETSGRLYPAGSNCIYVSEKLSL

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Crispr_ID: NZ_CP011934_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011934_2

849264-849360

Orphan

Consensus_repeat	Method
TGTGGGAACTCTTACAACTTAGAATTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011934_2

>merge|NZ_CP011934|2|849264-849360|CRISPRCasFinder
TGTGGGAACTCTTACAACTTAGAATTTGTCAGTTGAACTTTGGGTCGGAACTACATCCAGGTTTTGAATTTGTGGGAACTCTTACGACTTAGAATTT

>NZ_CP011934|2|2|849264-849360|CRISPRCasFinder
TGTGGGAACTCTTACAACTTAGAATTT	GTCAGTTGAACTTTGGGTCGGAACTACATCCAGGTTTTGAATT
TGTGGGAACTCTTACGACTTAGAATTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011934.1\|WP_000403251.1\|853767_854664_+\|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|163676
NZ_CP011934.1\|WP_000856975.1\|835064_835679_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP011934.1\|WP_000671554.1\|845933_847325_-\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	unknown	unknown	gnl\|CDD\|223842
NZ_CP011934.1\|WP_000619380.1\|857752_858079_+\|ribosomal-processing-cysteine-protease-Prp	unknown	unknown	gnl\|CDD\|184740
NZ_CP011934.1\|WP_000940600.1\|858068_858323_+\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NZ_CP011934.1\|WP_000099241.1\|847746_848505_+\|indole-3-glycerol-phosphate-synthase	unknown	unknown	gnl\|CDD\|140013
NZ_CP011934.1\|WP_000778963.1\|836825_838151_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_CP011934.1\|WP_001082135.1\|854660_855575_+\|TIGR02757-family-protein	unknown	unknown	gnl\|CDD\|378237
NZ_CP011934.1\|WP_000884017.1\|847407_847740_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP011934.1\|WP_000622605.1\|849595_850657_+\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	unknown	unknown	gnl\|CDD\|172940
NZ_CP011934.1\|WP_000981023.1\|844095_844344_-\|DUF1563-domain-containing-protein	unknown	unknown	gnl\|CDD\|203693
NZ_CP011934.1\|WP_001169648.1\|855639_856500_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|226383
NZ_CP011934.1\|WP_000559671.1\|835928_836789_+\|acyl-[acyl-carrier-protein]-thioesterase	unknown	unknown	gnl\|CDD\|238329
NZ_CP011934.1\|WP_001181794.1\|839864_840623_+\|biotin--[acetyl-CoA-carboxylase]-ligase	unknown	unknown	gnl\|CDD\|223417
NZ_CP011934.1\|WP_001068430.1\|850687_850972_+\|Cys-rich-protein	unknown	unknown	gnl\|CDD\|275246
NZ_CP011934.1\|WP_048657713.1\|842016_843912_-\|DUF1561-domain-containing-protein	unknown	unknown	gnl\|CDD\|284921
NZ_CP011934.1\|WP_001071952.1\|850986_852723_+\|glycosyltransferase-family-39-protein	unknown	unknown	gnl\|CDD\|224720
NZ_CP011934.1\|WP_000270913.1\|857441_857756_+\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NZ_CP011934.1\|WP_001258739.1\|857241_857451_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000928025.1\|840624_841398_+\|type-III-pantothenate-kinase	unknown	unknown	gnl\|CDD\|237347

Protein	Function_ID	Function_description	E-value
NZ_CP011934.1\|WP_000403251.1\|853767_854664_+\|hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|163676	cd07938, DRE_TIM_HMGL, 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain. 3-hydroxy-3-methylglutaryl-CoA lyase (HMGL) catalyzes the cleavage of HMG-CoA to acetyl-CoA and acetoacetate, one of the terminal steps in ketone body generation and leucine degradation, and is a key enzyme in the pathway that supplies metabolic fuel to extrahepatic tissues. Mutations in HMGL cause a human autosomal recessive disorder called primary metabolic aciduria that affects ketogenesis and leucine catabolism and can be fatal due to an inability to tolerate hypoglycemia. HMGL has a TIM barrel domain with a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. The cleavage of HMG-CoA requires the presence of a divalent cation like Mg2+ or Mn2+, and the reaction is thought to involve general acid/base catalysis. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	3.98702e-156
NZ_CP011934.1\|WP_000856975.1\|835064_835679_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.32908e-12
NZ_CP011934.1\|WP_000671554.1\|845933_847325_-\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	gnl\|CDD\|223842	COG0771, MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane].	1.98062e-117
NZ_CP011934.1\|WP_000619380.1\|857752_858079_+\|ribosomal-processing-cysteine-protease-Prp	gnl\|CDD\|184740	PRK14553, PRK14553, ribosomal-processing cysteine protease Prp.	5.50727e-28
NZ_CP011934.1\|WP_000940600.1\|858068_858323_+\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	1.63848e-52
NZ_CP011934.1\|WP_000099241.1\|847746_848505_+\|indole-3-glycerol-phosphate-synthase	gnl\|CDD\|140013	PRK13957, PRK13957, indole-3-glycerol-phosphate synthase; Provisional.	3.07092e-171
NZ_CP011934.1\|WP_000778963.1\|836825_838151_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.87939e-112
NZ_CP011934.1\|WP_001082135.1\|854660_855575_+\|TIGR02757-family-protein	gnl\|CDD\|378237	pfam09674, DUF2400, Protein of unknown function (DUF2400). Members of this uncharacterized protein family are found sporadically, so far only among spirochetes, epsilon and delta proteobacteria, and Bacteroides. The function is unknown and its gene neighborhoods show little conservation.	6.52672e-90
NZ_CP011934.1\|WP_000884017.1\|847407_847740_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	4.75168e-26
NZ_CP011934.1\|WP_000622605.1\|849595_850657_+\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	gnl\|CDD\|172940	PRK14465, PRK14465, 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN.	0
NZ_CP011934.1\|WP_000981023.1\|844095_844344_-\|DUF1563-domain-containing-protein	gnl\|CDD\|203693	pfam07599, DUF1563, Protein of unknown function (DUF1563). A small family of short hypothetical proteins in Leptospira interrogans.	3.35402e-15
NZ_CP011934.1\|WP_001169648.1\|855639_856500_+\|VOC-family-protein	gnl\|CDD\|226383	COG3865, COG3865, Uncharacterized protein conserved in bacteria [Function unknown].	6.13767e-54
NZ_CP011934.1\|WP_000559671.1\|835928_836789_+\|acyl-[acyl-carrier-protein]-thioesterase	gnl\|CDD\|238329	cd00586, 4HBT, 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).	5.80663e-10
NZ_CP011934.1\|WP_001181794.1\|839864_840623_+\|biotin--[acetyl-CoA-carboxylase]-ligase	gnl\|CDD\|223417	COG0340, BirA, Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism].	1.2041e-35
NZ_CP011934.1\|WP_001068430.1\|850687_850972_+\|Cys-rich-protein	gnl\|CDD\|275246	TIGR04453, Lepto_8Cys, Cys-rich protein, LA_1312 family. Members of this protein family occur, so far, exclusively in the genus Leptospira. Members, although small (about 90 amino acids), have a predicted signal peptide followed by a region with eight invariant Cys residues. Some members have an additional Cys in the signal peptide region that suggests handling as a lipoprotein, but this Cys is not well conserved.	5.08556e-29
NZ_CP011934.1\|WP_048657713.1\|842016_843912_-\|DUF1561-domain-containing-protein	gnl\|CDD\|284921	pfam07598, DUF1561, Protein of unknown function (DUF1561). A family of paralogous proteins in Leptospira interrogans.	0
NZ_CP011934.1\|WP_001071952.1\|850986_852723_+\|glycosyltransferase-family-39-protein	gnl\|CDD\|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	1.61961e-38
NZ_CP011934.1\|WP_000270913.1\|857441_857756_+\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	3.64764e-32
NZ_CP011934.1\|WP_000928025.1\|840624_841398_+\|type-III-pantothenate-kinase	gnl\|CDD\|237347	PRK13318, PRK13318, type III pantothenate kinase.	3.31134e-115

>NZ_CP011934.1|WP_000099241.1|847746_848505_+|indole-3-glycerol-phosphate-synthase
MSSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAGELRADYRPVQIAKTYEELGASAISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCLVEVHTSDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFMEKQDIRKAWLNLF
>NZ_CP011934.1|WP_000884017.1|847407_847740_+|STAS-domain-containing-protein
MLDHKVRDGVLIVYLKGRLDVSIANEVEENLNDLIDNQGHKKVILNMQEVDYMSSSGFRACISTLRKLNSKEGALKISNIKPAVKRIFDVIELTSLFDICETEDEALKSF
>NZ_CP011934.1|WP_000671554.1|845933_847325_-|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase
MKFPESLKGLKILVLGGGISGNSALNFLISEKAQPILCDQNQPERTVVPFFPDNIPPQSLPEVSLVIKSPGILPTHPILSYAADKKIPVVSEIDLGRYFFKGKIIGITGTDGKSTTTSLIAHLLKESFPDLKEGGNLGIPFTSFCKESISLAVLELSSYQLEDSSPLYLDVSVFLNLASDHLERHKTMENYFQAKLKIADLSNSNHTLIVSEKIKERILNSISYQCKLLSFGKTSDSNAFLDENSLKIKTSKFVYDISKFYLPGTHNRENLAASILAAEEIGGKPESIQTRIPLFRGLPHRFQIAGEKLGISFINDSKSTNLHSMLAGMATWKNIDQTCLILGGRPKQEDLKPLYNFLIRGIGCVVLFGEARVAWESGIKNIIGEKLYCVENLNDTFEIFKKGNVFPIPGLNKDIIIRLSGSISISSFVFSPACASFDQYKNFEERGNHFLSLVNDFLDQIDS
>NZ_CP011934.1|WP_000981023.1|844095_844344_-|DUF1563-domain-containing-protein
MMNIILIGFFLLETLENLYTTYVEYFLKQTFLDSIQKISKTDQKQNEIRVLPIFKILIFQVISSKGIFLSLSDNKIYQRYKL
>NZ_CP011934.1|WP_048657713.1|842016_843912_-|DUF1561-domain-containing-protein
MGRWIVLLLVLLVSLGVGYSYGVNPDVVPISSSDIPGSIIQRPTDKPKDKPIKVNVSSGGTFCYGPTFSGGESYIVIEQCWQMHVMNARYDVFQRISYNINDTWLCITVPESVVKGETNWDYVHLRPCTINDPLQRWIVKENSFWTADERYRLKDTNWYAYISRNSGDRYNHTLDSSMSDWINTVATPGNISILTSIAWNLGSDRYFIRSGGSDKNTTPIYYNPESGHLAQYNPVSGLLSCMYSRVGSYDWNWVTWALCSDAPISKDNPAYWNVYLTTKEGGMITDYQGNALRVTRYGPNWGVAYAAKLSYLKKDTTYNPTSLFIVDRDLLNWVRYTASNLGKTDQYCPAGKKESRAKRVKRTLPSDFQLTEEWIQRLYDIAISTVTNPQVSGICGVCLLQTFQMLAELQEYHSREPLQSGGYFFDTAPNRDPFISFRQRYPELDSSLSHIPRVYNSDSTTLRLLTLVSAMNMMPLYNWTPSREFTTRSEILSHITSLIGSPAGSIWLALMRRQRPDGTIAGHSVPILRTSEGLVVIPTRVPSSVSLELYREYLTPTMDPIQAINNLEQPDRTLTYFVTIQLGEFYDNFTDLVISNRNCTGEGEGRRGTGEYPASATVNQCSESRCALPSQ
>NZ_CP011934.1|WP_000928025.1|840624_841398_+|type-III-pantothenate-kinase
MLLVVDVGNTNTVFGIFENGNKIPLFHKRTVTRKDRTSDELGLFFRGFLREFKIENEMITGGIYSSVVPTLNPILDRMFQDWFKIEAIRVHYQMKLPFSISYPRPYEIGADRLVNAATCAIDFPGKSIIIDLGTATTFCVVNEKPEYLGGVIAPGLKVSMDALTRNTSQLPPIVFQSPGKILGDSTIESIQAGFFFGWIGLLEGIIREIKKDKGQDYQVIGTGGLVTVIDAAHPGIFDKIDPLLTLRGLQILHLMNS
>NZ_CP011934.1|WP_001181794.1|839864_840623_+|biotin--[acetyl-CoA-carboxylase]-ligase
MQNVLLQPEKGIFLDSVTSTNTVIKGKEFPHGTWIVAEEQTAGRGRKDRTWEVFGEESLIFSGKIGLENFDAGPGLSLFIGTAVCKTILSVYPELTREIKIKWPNDLYRGNKKVAGILIESEIEGSFMTLIIGVGLNLYGKNESIPNHLTDAGFLNTNPNRAGKKNEILEKLVPFLNESILLWKDPEGRKKELILLNELLLWKGQSVRYKENGQLQTGILEGLSENGSLILKTPSGTRLDFIDSPEDFHSLN
>NZ_CP011934.1|WP_000778963.1|836825_838151_+|thiolase-family-protein
MKLTKPLAICTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGFSNAPNSARVIANLVGMRDEIACITVANNCVSGMEAVAEAARRIVLGEGEVFLAIGEESQTSMPFVVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLEDGLGDGETSYGMQVTAEIVAQNYGLSREIQDKLAFESFKRALEASKAGKYSPYIIPMKDDEGNELTIDEAVGLREGLVENPTRMGRAMLMFDNPGMKFEEFKTKYAKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKAKELGLTIEAVVSGWHMKGVHPNNMGIGQAVATKALLDETGIKIQDVDYVEIHEAFAATAVGALEQIKMDTGWDWEKSFDAKKINPNGGSIAIGHPFGATGIRLIANAIMDLKEDSSANKVLITACAHGGIAGSMLIERYKG
>NZ_CP011934.1|WP_000559671.1|835928_836789_+|acyl-[acyl-carrier-protein]-thioesterase
MIADEIQLVTRISDLDTQRHVTSRTYENFCLEGRFRTLEKNGFSIREILSQGIKIHPLESQIRFLAQQMEGASLKTETKAFPLKDGKIFWDQKVLSDIGTIAAEIKTLTFSEKDGHPIDLLPLEKTEMSGFDQFPQIPDFRGTCKTVDTSMITLYSERNIFGEYNPAYLWRIVEDSRWFFSTETGLTLDRFVEMDTTLFFMGGVFRFFHPVPAGRKIKVSTWIHSFEKIRSYMRHEVTDIETGLRYFAVQDEQLVVSLTKSRPKKAPDEFQQLVGDYVENFEYSKK
>NZ_CP011934.1|WP_000856975.1|835064_835679_-|TetR/AcrR-family-transcriptional-regulator
MKTQPRKKKESGTGVRERILDTATSLFYKQGFSSTGMRQIIQESNSVAASLYDHYPSKKELGLAYLARQEEKTLSDLQSLMDRYPDLGEFLRAWVILKEKQIRHGEFVGCPFAGFASQVMDSDPEYTEFLKDIVNKWIRMISDYLQKAIGSGQLKRNMDIQYVARRILMAYHGSITMWRMTQELRFIREMDDSLREIVEEYRIL
>NZ_CP011934.1|WP_000622605.1|849595_850657_+|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN
MISENLGENQTEKIPLKGRTLKELSEIMITLGEKPFRAKQIYHGLYVNRYETWDQFTTFSKIFKEKLEELCSLTHLQVVKQLKSVDGTQKFTFTSESGNGKEFEAVWIPSGDGGRKTICISSQIGCTLNCKFCATAKLEFQGNLKAHEIVDQILQVEKIVGDKATNVVFMGMGEPLHNYFNVIRAASIFHDPDAFNLGAKRITISTSGVVNGIRRFIENKEPYNFAISLNHPDPKGRLQIMDIEEKFSLPELLQAAKDFTRELKRRITFEYVMIPGVNMGSENANKLVKIAKSLDCKINVIPLNTEFFGWRRPTREEIAEFIALLEPAGVPILNRRSPGKDIFGACGMLASKS
>NZ_CP011934.1|WP_001068430.1|850687_850972_+|Cys-rich-protein
MNPKRTIILFLYLLPFVSCQEYVQQKCNSACKFFVQCAMNDFKHVKVTELEKNQMMIDCESGCIREQGFVLPCFESETTCKGFNTCVMESGFMD
>NZ_CP011934.1|WP_001071952.1|850986_852723_+|glycosyltransferase-family-39-protein
MNQISVDNKQPISVWILFIFLIVSVLPLILTLPLDMIDIDSSQYAEISREMVEGRNPFFIRDNGRRYLDKPILTFWKISLSFLIFGYQNFAFRLPALLFTFFSFWGIFKLTELYSESCLRAWISVFLYALSPGLYSMVVDPKIDVYLTPYLILVHTFYYLGFKRNQNYYYLMYFAMGLGFITKGPIAMVIPSISIGGDILFRRDWRRLLEMKLFPGVLLAILPPLLWSIPLYLEFQTYGPYFFLWIQSFGRFYVKMYNQKFNPLFFYSNFSWAFGVFILPFFGFVFDRIVTFLKQNKGKEVFQNILKNKYFNLDFVIGFWLFLFLFLISFSRYQLPQYIYWCLPAAAVIGSGVLESILLSLKDQKNKSWFNKLNQGLLLVTAAVFLIAVLVIPWISVEVGWSYLILPLVYLGVFLWVFFKSSTIGRLLAFWIFSASLFFSIVSLYLYPMLTSFQPSKEIGIWIRKYEPNKDKLFLFGVPASKRSYAYYSRRISRTLFDPAVLIDSVQKDGQRYLIVQDKWLPKLEEFFGNNLQFETVKEFPSYKVATPEGKFFLKSHRDQIVGKVILMRASRKDFQKK
>NZ_CP011934.1|WP_000403251.1|853767_854664_+|hydroxymethylglutaryl-CoA-lyase
MEIKITEVGPRDGLQNEKSPVSTEVKAEFIQRLVRAGLKNIEATSFVKKDSIPQLADATELSAFLDLNGSVSFSALTPNLKGYEAAKSAGYKEVAVFTAASESFTKKNINRTISESIEGFKDIFNFSKIDEIQVRGYVSTVIDCPYEGKMNPKKVLEVSKILLDLGAYEISLGETIGTGVPTEVEKLLEVLLKEIPANKLAGHFHDTYGMAIANVEKAYSMGLRSFDSSAGGLGGCPYAKGAAGNLATDDLVYFLEKSGISTGIDPNLLWEASLFMEKSLSRELQSRTFLATKKKRES
>NZ_CP011934.1|WP_001082135.1|854660_855575_+|TIGR02757-family-protein
MNRSSQKIKRVLENLFLEYQTSDYLRSDPVEFPHLFSDLRDREISGFISALFSYGNITAIKDHLKRIFAICGNSPYRFLLNEDLKSIRKNLKSYRFQKPEDTYLFLQTIQNKLRTTEGHGLESLFSLPEEGEFQFSSRDQKSFLEGGSLRRRILSFQLRFLKESSKIDSKQTKSYGYKFLVGQGIRSTSLKRYSMFLRWMVRKEFPDFGIYSSISPSELQFPLDVHIQRIASVLNLSSRRSSDWKKAEEVTDFFRAIFPDDPVKADFALSRLGILKKCKSKYLRELCESCGIRSICKVYEGFSK
>NZ_CP011934.1|WP_001169648.1|855639_856500_+|VOC-family-protein
MQKITPFLMFDNNLGEALKLYASTFSDWKLLSQNQTGDVVMSATFAISGKEILSFNGGPHFKFTPAISFFLSCQTSKEVEKIWASLSQEGIVLMELQEYPFSEKFGWVQDKFGVSWQVCLSKEGNDLVTFLMFVGKQHGKAEEAIRFYTSQFPNSKINDIQRYTTDQSEKEGTVQRSVFSIAGQDLMAMDSGLDHAFTFSEAYSFFIKCETQAEIDKYWEKLSFQGEKQKCGWVKDKFGVSWQIIPSILGDYLQDKDPKKSQRVLQAMLQMDKIDIVKLKRAYDSN
>NZ_CP011934.1|WP_001258739.1|857241_857451_-|hypothetical-protein
MRTFLSGLFWSRFQPIWLTRLVGQGEIRSYGIGKKYFLKTIIYNDDIWNSMFYEFLVSLRSNQKLVEST
>NZ_CP011934.1|WP_000270913.1|857441_857756_+|50S-ribosomal-protein-L21
MYAIISVGNRQYKVTQDQEFLTEKTGKNAGESFDAKVLLFAESNNKVHIGQPELKTARVSLKVLEDVKGDKIHGYVYKRRKNYQKAWGHRQQLQKVKVVSLSAV
>NZ_CP011934.1|WP_000619380.1|857752_858079_+|ribosomal-processing-cysteine-protease-Prp
MIRIRITRTGEFYSSLESEGHSSVSLGKKGENLLCSAVSVLVQTLYLYLLQSGKTKPAEVRDGYLRFEVLEQDVLIQNSFDLVLSGLKNLKNQYPTEIELIGVPENGT
>NZ_CP011934.1|WP_000940600.1|858068_858323_+|50S-ribosomal-protein-L27
MAHKKGGGSSKNGRDSNSQRLGVKRFGGESVLAGNILVRQRGTKFRPGNNVGLGKDHTLFALVTGKVKFEMVTKLKMQVSVYPE

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Crispr_ID: NZ_CP011934_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011934_3

1271415-1271504

Orphan

Consensus_repeat	Method
GATGCATTGAGTTTAGAAGTGAGACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011934_3

>merge|NZ_CP011934|3|1271415-1271504|CRISPRCasFinder
GATGCATTGAGTTTAGAAGTGAGACGCTGAGTTTCCCGAACGACCACAGAGCGACTCTAAAAGTGATGCATTGAGTTTAGGAGTGAGACG

>NZ_CP011934|3|3|1271415-1271504|CRISPRCasFinder
GATGCATTGAGTTTAGAAGTGAGACG	CTGAGTTTCCCGAACGACCACAGAGCGACTCTAAAAGT
GATGCATTGAGTTTAGGAGTGAGACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011934.1\|WP_000150993.1\|1278171_1278495_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377300
NZ_CP011934.1\|WP_000625244.1\|1268828_1269845_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP011934.1\|WP_000273875.1\|1279256_1279997_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000852853.1\|1259539_1259812_-\|DUF736-family-protein	unknown	unknown	gnl\|CDD\|133956
NZ_CP011934.1\|WP_000567063.1\|1267557_1268514_-\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|234599
NZ_CP011934.1\|WP_000850112.1\|1258877_1259474_-\|LemA-family-protein	unknown	unknown	gnl\|CDD\|377192
NZ_CP011934.1\|WP_000623631.1\|1280111_1280810_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000615880.1\|1272220_1274152_-\|single-stranded-DNA-specific-exonuclease-RecJ	unknown	unknown	gnl\|CDD\|273193
NZ_CP011934.1\|WP_001192265.1\|1281724_1283653_-\|NAD(+)-synthase	unknown	unknown	gnl\|CDD\|143594
NZ_CP011934.1\|WP_000610208.1\|1256772_1257336_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226285
NZ_CP011934.1\|WP_000670773.1\|1269898_1271362_+\|polynucleotide-adenylyltransferase-PcnB	unknown	unknown	gnl\|CDD\|130997
NZ_CP011934.1\|WP_001283362.1\|1266166_1266790_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP011934.1\|WP_000444202.1\|1261860_1264707_+\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|224588
NZ_CP011934.1\|WP_000823113.1\|1275195_1275915_-\|glycoside-hydrolase-family-25-protein	unknown	unknown	gnl\|CDD\|119375
NZ_CP011934.1\|WP_001122024.1\|1276928_1278095_-\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341486
NZ_CP011934.1\|WP_001083567.1\|1278507_1279260_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|381175
NZ_CP011934.1\|WP_082280251.1\|1264899_1265085_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000618030.1\|1276512_1276932_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_001278842.1\|1274154_1274475_-\|polymer-forming-cytoskeletal-protein	unknown	unknown	gnl\|CDD\|377376
NZ_CP011934.1\|WP_001170200.1\|1260254_1261625_-\|DUF389-domain-containing-protein	unknown	unknown	gnl\|CDD\|377221

Protein	Function_ID	Function_description	E-value
NZ_CP011934.1\|WP_000150993.1\|1278171_1278495_-\|hypothetical-protein	gnl\|CDD\|377300	pfam04316, FlgM, Anti-sigma-28 factor, FlgM. FlgM binds and inhibits the activity of the transcription factor sigma 28. Inhibition of sigma 28 prevents the expression of genes from flagellar transcriptional class 3, which include genes for the filament and chemotaxis. Correctly assembled basal body-hook structures export FlgM, relieving inhibition of sigma 28 and allowing expression of class 3 genes. NMR studies show that free FlgM is mostly unfolded, which may facilitate its export. The C terminal half of FlgM adopts a tertiary structure when it binds to sigma 28. All mutations in FlgM that prevent sigma 28 inhibition affect the C-terminal domain and is the region thought to constitute the binding domain. A minimal binding domain has been identified between Glu 64 and Arg 88 in Salmonella typhimurium. The N-terminal portion remains unstructured and may be necessary for recognition by the export machinery.	0.00215375
NZ_CP011934.1\|WP_000625244.1\|1268828_1269845_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	5.85427e-40
NZ_CP011934.1\|WP_000852853.1\|1259539_1259812_-\|DUF736-family-protein	gnl\|CDD\|133956	PHA01740, PHA01740, putative single-stranded DNA-binding protein.	0.00028157
NZ_CP011934.1\|WP_000567063.1\|1267557_1268514_-\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|234599	PRK00052, PRK00052, prolipoprotein diacylglyceryl transferase; Reviewed.	9.24889e-45
NZ_CP011934.1\|WP_000850112.1\|1258877_1259474_-\|LemA-family-protein	gnl\|CDD\|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	3.91437e-76
NZ_CP011934.1\|WP_000615880.1\|1272220_1274152_-\|single-stranded-DNA-specific-exonuclease-RecJ	gnl\|CDD\|273193	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ. All proteins in this family are 5'-3' single-strand DNA exonucleases. These proteins are used in some aspects of mismatch repair, recombination, and recombinational repair. [DNA metabolism, DNA replication, recombination, and repair].	4.20612e-72
NZ_CP011934.1\|WP_001192265.1\|1281724_1283653_-\|NAD(+)-synthase	gnl\|CDD\|143594	cd07570, GAT_Gln-NAD-synth, Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases). Glutamine-dependent NAD synthetases are bifunctional enzymes, which have an N-terminal GAT domain and a C-terminal NAD+ synthetase domain. The GAT domain is a glutaminase (EC 3.5.1.2) which hydrolyses L-glutamine to L-glutamate and ammonia. The ammonia is used by the NAD+ synthetase domain in the ATP-dependent amidation of nicotinic acid adenine dinucleotide. Glutamine aminotransferases are categorized depending on their active site residues into different unrelated classes. This class of GAT domain belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to classes 7 and 8. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase forms a homooctamer.	1.04411e-82
NZ_CP011934.1\|WP_000610208.1\|1256772_1257336_-\|hypothetical-protein	gnl\|CDD\|226285	COG3762, COG3762, Predicted membrane protein [Function unknown].	4.9301e-25
NZ_CP011934.1\|WP_000670773.1\|1269898_1271362_+\|polynucleotide-adenylyltransferase-PcnB	gnl\|CDD\|130997	TIGR01942, pcnB, poly(A) polymerase. This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).	2.20032e-95
NZ_CP011934.1\|WP_001283362.1\|1266166_1266790_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	4.89057e-08
NZ_CP011934.1\|WP_000444202.1\|1261860_1264707_+\|DNA-translocase-FtsK	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	5.95273e-146
NZ_CP011934.1\|WP_000823113.1\|1275195_1275915_-\|glycoside-hydrolase-family-25-protein	gnl\|CDD\|119375	cd06413, GH25_muramidase_1, Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.	1.7479e-116
NZ_CP011934.1\|WP_001122024.1\|1276928_1278095_-\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341486	cd14864, Fe-ADH-like, iron-containing alcohol dehydrogenases (Fe-ADH)-like. This family contains iron-containing alcohol dehydrogenase (Fe-ADH) which catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. Its activity requires iron ions. The protein structure represents a dehydroquinate synthase-like fold and is a member of the iron-activated alcohol dehydrogenase-like family. It is distinct from other alcohol dehydrogenases which contains different protein domains. Proteins of this family have not been characterized.	8.36121e-118
NZ_CP011934.1\|WP_001083567.1\|1278507_1279260_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|381175	cd11648, RsmI, Ribosomal RNA small subunit methyltransferase I (RsmI), also known as rRNA (cytidine-2'-O-)-methyltransferase. RsmI is an S-AdoMet (S-adenosyl-L-methionine or SAM)-dependent methyltransferase responsible for the 2'-O-methylation of cytidine 1402 (C1402) at the P site of bacterial 16S rRNA. Another S-AdoMet-dependent methyltransferase, RsmH (not included in this family), is responsible for N4-methylation at C1402. These methylation reactions may occur at a late step during 30S assembly in the cell. The dimethyl modification is believed to be conserved in bacteria, may play a role in fine-tuning the shape and functions of the P-site to increase the translation fidelity, and has been shown for Staphylococcus aureus, to contribute to virulence in host animals by conferring resistance to oxidative stress.	4.63727e-101
NZ_CP011934.1\|WP_001278842.1\|1274154_1274475_-\|polymer-forming-cytoskeletal-protein	gnl\|CDD\|377376	pfam04519, Bactofilin, Polymer-forming cytoskeletal. This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria. In the example species C. crescentus, two bactofilins assemble into a membrane-associated laminar structure that shows cell-cycle-dependent polar localization and acts as a platform for the recruitment of a cell wall biosynthetic enzyme involved in polar morphogenesis. Bactofilins display distinct subcellular distributions and dynamics in different bacterial species, suggesting that they are versatile structural elements that have adopted a range of different cellular functions.	1.96443e-27
NZ_CP011934.1\|WP_001170200.1\|1260254_1261625_-\|DUF389-domain-containing-protein	gnl\|CDD\|377221	pfam04087, DUF389, Domain of unknown function (DUF389). Family of hypothetical bacterial proteins with an undetermined function.	5.83275e-59

>NZ_CP011934.1|WP_000670773.1|1269898_1271362_+|polynucleotide-adenylyltransferase-PcnB
MKFLSNLFKKKIGSVEDILSHPDGKRYYRDAHLIRKNMIDEDAVKIIHRLNKFGFKAYIVGGGVRDLLLGRKPKDFDVVTNATPNQIKKIFNNCRIIGRRFKIVHILFRGKVIEVSTFRSLPDYRLGKAVEDQDYLIKRDNKFGTPQEDAARRDFTINSLYYDVRNDSIIDYVGGFEDIRNKVLRVIGDPDISFREDPVRMLRAVKFAEILGLNIEKTTAKAIRKHKTELEKASSSRMLEEYNKIFRTWKTSLIFQGMAEHGILEVLFKEAFDKERKKNSNFGEKFLETNIGKRLAIADKLLTEREEMTPHIFYSLIFSDLASEALQKENMHLVPAIKNSLELIFRRLETPKKDKDRLIKIFASQQRFLSTEDEKSSQNNFFRMKDYFYDAFMVFKIGAIAENDEKAIQSAFFWEISVRKRPTPVKKFNGARPNKSRNRNFQKNREEDRSNRREETQSSSESEKQNRKNQKENSQEDFSSEDSGNEF
>NZ_CP011934.1|WP_000625244.1|1268828_1269845_-|M23-family-metallopeptidase
MISPAKYDLKLTHSERLQVKILKFKNRFRKFKESGSKKISFLLVPHSHENVITIELNVFMAWFLGILSGLILILAFLFLSYLNFFYRPDQDLFQKSDENVSQYLYYDMLLQDAKKEIRGLERKTEQLNLVAWDEVPWKRILTYEVIPEFHLKKEIPDSETNLELYKNTVEGFAVQNIELFRIRQAFENAFDYLEERESILYALPRGRPLKPGVGFVSSTFGGRVDPFGLVILGEHHSGVDFASAEGTPIYATAPGVVVESGQSSGGLGRNIKINHLNGIFTVYGHCSQILVEKNQIVKRGDLIGLVGSTGKATGPHVHYEVHIGQDPPLDPAEFINIE
>NZ_CP011934.1|WP_000567063.1|1267557_1268514_-|prolipoprotein-diacylglyceryl-transferase
MIDRIPVPFLNPLFKFLFNREWDGPSTFSILMMIGFLTASYLLPKELKRRKLEPEHSDWLLLLGILGTLVGAKIFFVFEIWDQIFVETPGFDGKYIYPLTHWYGFPGRMSLWDNLFSGSGLVFYGGFLFGILFITLYMKYFQLDIASYLDAAVPSMAIGYAIGRLGCWVSGDGCYGFATNVEIPLLVFNYHGAHPSGVPVWNTPLIESIISFLFFFYFQFWARNQNFKKFSIGAQYLVLHGFARLLVEFLRVNKAVFPLMDPPAFVNIPNAEQNPEFLTQYYWHGFSQSQLVSIIIILVGAFFILKWKLWKKESISNV
>NZ_CP011934.1|WP_001283362.1|1266166_1266790_+|class-I-SAM-dependent-methyltransferase
MSDPWTDRWNERYNKEEFAFGEQPNEYLKEQLEKLKIGTILFPAEGEGRNAVFAAKLGWNVSAFDISIEGKKKAFRLAEANQVKIDYQVGELQTLDYHSEQFDAIALIYAHFPAEIKSYYHKTLSQYLRKDGLVILEAFSKKHIHYVLKNEKVGGPRELEMLFSIDEIKTDFENYEIIELEEKEIELKEGLFHNGNGSVIRFVGRKR
>NZ_CP011934.1|WP_082280251.1|1264899_1265085_-|hypothetical-protein
MWEFLQITSPRNRLSFLEFDFCNSSHVLRLFWIIYVISQTQDCENHLNSKWKEWEFPHLKN
>NZ_CP011934.1|WP_000444202.1|1261860_1264707_+|DNA-translocase-FtsK
MESKPKEFKPTWNLQNGKMILPYVLLFTGIILTLSLGSFDAGERGVEYNFFGRLGYYISYGMFFMFGAASFLPGLFTIGLGSLRLVKEEFELTNRLFSIPVFLLCYTVTLQVTGHVSTIPFASQGGFVGQLLSSGLEFVFGSTGKILIHLVFYFYGLILLLNESPLHFIGRILGTAGAKYKEGFKSGFGKRGESLGSLFQSAVEKFQKKESVPPWISTNTNEKNSLNQSYSLSNPHTHSYERNLGNKQPSELQNTLHSTFGKEGKLSDFLSKVDTGPTVTSKNSRIRFQNHGAFSGNFEEQGKVFRFESVSSSLSEKIREEKNFQKTPSRWEILDFRTSSFSNIISEKEPSVTLVVPSESEIKKEWNQTNPILQSEEIPDKFLFEEKEKVEQTDSGLENECYEEESVDSEENLSEEETLSSETSTEKDISENFKTSTISNSKEVSPNHISNSSIHSLEKSEEKLELGLPFPPTTLVPEVKSKRSIYHVPLKSLKTTTTKIQDPLFKIEADKVARKIEEIIRQYGYESQVVSMERGPIITRYELTPPLGVKLGRITSLSDELRLYLAVKNIRIVAPIPGKSTIGIEVPNSIREDVFLGDILHQNLSLRPKKDLSILIGKDISGKLVGIDLNKLPHLLVAGTTGSGKSVCLNSMISSLVVHLSPEEVRFIMIDPKMVELTLYEDIPHLLMPVITDPKKATRALAWAIQEMEARYHSVSKLKCRDFKTYNEKVEQGAHRDGYKKMPYIVIFIDELADLMMVSGKDLEDAITRITQKSRAVGIHLIMATQRPSVDVITGLIKANCPARMAFHVAQKTDSKIILDQNGAESLLGKGDFLYKSPTAADLIRIQSPYVSEEEIEKIVEEARKFGKPSYVDFNLDEETESSVVDEGDEELFEQAWEIVRTDRKASASYLQRRMRIGYNKAARLMELMEERGYVSPQIGSKGREILK
>NZ_CP011934.1|WP_001170200.1|1260254_1261625_-|DUF389-domain-containing-protein
MQKKSSHNPEPNFWDLLAPLFEFINPLLHIRNDTDETGTIESIKRGVNFSGSALWTLIFAIFIASIGLNINSTAVIIGAMLISPLMGPIMGAGLALGIYDFELLKKSLRNLAVMTFLSLFTSALYFLISPLSDAQSELLARTSPTIYDVLIAFIGGATGIVAGSRKDKISNAIPGVAIATALMPPLCTAGYGLANWNFKFFLGAFYLYLINSVFIGISTLIFVRYLKFQRTVYTDPAVDKKIYRYVYLLSACLILPSIYFAYDIVVDSAFKRNAKSYLENQFTFEKSKILSANIVRKGGEKKIEVTMIGETLSEDILSQLKTILPKYGLEDTELKVIQSYRDSSQLNQQSGFSFQNEAGSKIQEEKIHLLENELRILKDKDHLAQSVAKEINVLFPSVDSFSLGDFLVQNVQDFSSSKEVTVLVKWKHQVGSVERKRLELFLKLRLGLENLQVLDL
>NZ_CP011934.1|WP_000852853.1|1259539_1259812_-|DUF736-family-protein
MAEYTLKEKKGSLFSNAAKEKETQPDYTGKVLLEGKTYRLAGWIRKSATGKNYLSLSLSEPNLEKKSAGSSVITVTDGNDFTDIEEDFPF
>NZ_CP011934.1|WP_000850112.1|1258877_1259474_-|LemA-family-protein
MKTKIDFKLFLITTLTLLVFSNCGYNTIQEEDEVINASWAEILNQYQRRSDLIPNLVNTVKGYATQEEKVLIAVTKARAGVGSIQADEKTLNNPELFKKYSQAQAQMTSALSKLLVIAENYPELKSNENFRDLQAQLEGTENRITVARNRYIQAVQKYNVTIRKFPNNITAKFFGFETKPSFSVENEKEISKPPEVKF
>NZ_CP011934.1|WP_000610208.1|1256772_1257336_-|hypothetical-protein
MINQYINKKATILRIWNHTLESVLSFFYFSQSKPKSYRFKKYFSTEDLEKIESAVSKSEILHKGEIKVILESGLSVFRIIEGLTTKQRAEELFSQKRIWDTEENTGILIYIQLIDRKIELLADRGIYKKIGQGKLDEICQRMEAGFRSGHYLESILFAIEEFTLLLQKYFPSVEQNPNELSDKPEVI
>NZ_CP011934.1|WP_000615880.1|1272220_1274152_-|single-stranded-DNA-specific-exonuclease-RecJ
MIQPSPFSHGPGLKELHPAGLRPHFSPLQHRFYETHLREKSHPEHLLYHGLRELPSPFLLPDLEPALDLLKEFIQKEKKILLFGDRDCDGVSSTSLLGSFLKKIHRGELILKTSNEEDYGLCPAALDFVKRIKPDLLITLDFGTTNHIQIDELASIGIKVIVLDHHEIPERIPDCYLISPKRSDSIYPNEKICTSVLALKFIQAYLYSSLEEYNRATWIGDGNSLFSGFLIYRGKLLFQGDRQEAESKFSLTIQDESYSFQSSYPEREWFYQEFLKYPAILEQYLQNFDLASIGTVSDMMPLYGENRIIVREGCKILFKLHKKETSHREGLFQLLQLMEFADNRVTSKDLGWGLGPMINSAGRMNRTDVALNLLLEENPELAKSGAKELQKLNEERKERTKRNIFKVDSFLKRKKERTERSVLFCYEPDFEPGVSGIVATRLVEEYKRPVLFITPDHGHAKGSIRAYGKENVLNLLKKAESVFLQFGGHKEAGGFSLEIDKIPELAKLIFDNADNWLAEEQMTSTSEQTESLISLKPEELNPKIFQELSIFEPFGHENPIPLYSIKNAKIYHTKPMTDGKHVRFRILGAPESIQCLIWNRGKDFLELISKSVSLDLWGSLEESTFRSKTSLQFIVNYFQESEN
>NZ_CP011934.1|WP_001278842.1|1274154_1274475_-|polymer-forming-cytoskeletal-protein
MSDEQIDTVIGDDIHFRGKLKFNNSLKIKGNFKGTIETTGKLVVGDTGEVEADIQTGTLEVEGNLKGNVSANQKVAIRKTGKVIGDIRTPDLEIESGAKFSGNSAM
>NZ_CP011934.1|WP_000823113.1|1275195_1275915_-|glycoside-hydrolase-family-25-protein
MKRKFLFLLVIISFFLLGIGLYNALNSGKIWFVYPSTSQYPIRGIDVSNHQGKIDWSLVPKSEISFVYIKATEGRDFKDKSFHLNWKKAKANGFFVGAYHFFTLCKSGKEQAENFISTVPKEIDSLPPVVDLEFLGNCKERSSMKDISNEIQEFLNRVDSHYGKKTILYLTYEFIDRYIGPNFQDHPIWIRDLFKHPNTFSNQRWILWQYKSRGSLPGISGPVDMNVLNGELKILTLTK
>NZ_CP011934.1|WP_000618030.1|1276512_1276932_+|hypothetical-protein
MIRHYAFLFLWLFGVSLILISGKQPNPYLVHVRKIPLPHAYPWEEVLTYCLLITVEILVLYWILRPKTYNLSWLRSLSGSLFFFILGGAHLFTLMHAPSYMLFHCMYLFCIGIMIFVFSMWALVNKNRFGSNSKESINP
>NZ_CP011934.1|WP_001122024.1|1276928_1278095_-|iron-containing-alcohol-dehydrogenase
MPILPDWVHYTFPPKIHFEADCGYKVGNFVKNIGSRTVIFSTQQELENMDELSVIKTSLEKHIDGVILYDDIAKEPSPEELDTAAYFAKIANADCIIGYGSYESISMAKLIALLITNDIFAEDMINDRKLKLKKPIPLILIPTHPVFGLECSPISTILLGDEKITRYFSHELLFPELIIADPKISSFMSSMDISKVGVGILAAAVDTILSKFSTELTISSALRAIELLQKNLIPSIRDPKNVNYKNGLYAASLLTGIAQSSSSLGLCFALSLASSNITNLDIFQSMSILLPHVMEYNLTSSAGKYVMIARALDEDITNISVIEAAIKAVEGIRKIFIELKIPQRLSEYEVRKMDLPSIANLAASFPFLDSLPRELPKNEIETILIAAF
>NZ_CP011934.1|WP_000150993.1|1278171_1278495_-|hypothetical-protein
MTIDKIGGIGGSGYEPKRTAPVKKTESKETFDNVSISDTAKQKASEAKLQAEIQTITRKILSTPDDQDRSVKLKEIKEKLKNGDYDNLSPEVLNTIADRISETMLGQ
>NZ_CP011934.1|WP_001083567.1|1278507_1279260_-|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MNSEEESSEIPLEPGTLYVVSTPIGNLEDLTFRALRILKNTDRILCENSGHSKKLFRSYSIHTQCSTLYKDQSENPYLSILEELKEGKTFALVSDAGTPGISDPGSHLIRVVREKGFKISPIPGPSALTALLGISGWQANPFLFLGFLSEKKGKKRNQLYEWKEFEGLIMIFESVHRIEDTLNSIQEVFSDCEFLIGREMTKIHEEILHFSPFATEKSKEFASKGEFVVLINTNRKKMLKGSIGSADRIQ
>NZ_CP011934.1|WP_000273875.1|1279256_1279997_-|hypothetical-protein
MYFQIFRSTSLPILTFIWILFGCGMNTDVAQSPFIFISPVGVPQFLSILAVNEGITDTATKDTDFQSEPNSYKPEFLVRYYVTNAEPQFVGYNLYITTAAPSVAETLTSGNVYLENGVQPSFPHLASEASTSSSKLQTHRVLNQIPPPGVFPFIKCEIYTFTMRALLNSGIFSNPSTPVKMCSSSRPFLCPVGSSCNPAECNNSSCTTAVKQNCPVGTLCNPCTISGSEETGCICPTGVSPPGCNL
>NZ_CP011934.1|WP_000623631.1|1280111_1280810_+|hypothetical-protein
MISIRKLVIYSGISISLIVLVWILFSSEDSSEKERKSKEADSVALLLGGGSPSSGSGSSGGKTNESIFDSSFYKSGKGEYIESDKGEPKEADPNAADADNPVNPQTNKPYTNEEMERFSQLRERFPDNSLIPKKLSPAEKEAKRQEDSRIAEAARNVFARTATHDQIRSYYQNMEKQTQDRMDIINYLVDLQKGSGEEETEKKLNNIQESIKNQLQQVQKEKENAFKQAGIL
>NZ_CP011934.1|WP_001192265.1|1281724_1283653_-|NAD(+)-synthase
MQSVRLTSVSLKTKVFDFQGNLEKIKRVLELEKKSDLILFPELCISGYGCEDAFYFPRIWKKSWNSLIQLLPHTENKIIVVGLPIFQNPYLFNCAAVLCNGVVAGIVPKSNLASTGVHYENRWFTRGEESQENFIAPDGSTIPFGSLIFETDHFSFGVEICEDSWVLQKPSIPLAEAGTDLILSPGASHFAFGKQRIRRQIFQESSRRESNVYLFSNLCGNESGRLIFEGGSMIVQNGKLLSESERLFFGDFSLCSNEIDFEASQADRAKNFRPSGNRFSKTKSTEENKIYLGIEFPKRVPKVNKSLLEISISKEEESYLDFTKAVALGLFDYLMYSNTKGYTLSLSGGADSSACALLVTAMKKIAKLELGENFFKSKGIPEESILCTLYQSTSNNSDRTKFLAKSLAEEIQSIHGDLTIDSEIQSISEKISKLTGISLRWYEHNLTLQNIQARVRSPIIWMLANLNGHLLLSTGNRSEASVGYTTMDGDSSGSIAPLTGVSKEFILKWLRFVSEGKDPILPAYPSIKEIVNSPPSAELKPPEDKQEDEKDLMPYPLLQKIEELFIVRGAGYSEIIQLLSEDSEIQNLPPRFLEESVKKYISLFHKNQWKRERLPPSFHLDDYGLDPKSSFRFPILSEDIEL

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Crispr_ID: NZ_CP011934_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011934_4

1406068-1406642

Orphan

Consensus_repeat	Method
AAAGAAATTGGAAACTTAAAAAA	CRISPRCasFinder

8 spacers

The CRISPR arrays of NZ_CP011934_4

>merge|NZ_CP011934|4|1406068-1406642|CRISPRCasFinder
AAGGAAATTGGAAACTTACAAAATTTAAAAGAATTATATTTAAGCGCGAACGAAATTACAACTCTGCCTCCTGAAATAGGAAATTTAAAAAATTTACAGGTGTTATCTTTAAATGGAAACAGACTTGAAACAATTCCTAAAGAAATTGGAAACTTAAAAAAACTAAAAGAACTGTCGATAGAATGGAATAAACTTCAAACACTTCCCAAAGAAATTGGAAATTTAAAAAACTTAAAAGAATTATATTTAAGCAGAAATCAACTCAAAATATTACCGCAAGAAATCGGGAACTTAAGAAAACTACAGCGTATGCATTTAAGTACAAATGAACTCACAAAACTCCCGCAAGAAATCAAAAACTTGGAAAGTTTATTAGAAATTTATTTATATGATAATCAGTTTACAACACTTCCCAAAGAGATAGGCAATTTGAAAAATTTACGTAATTTAGTTTTAGGCAGAAATCAACTTATATCGCTACTTCCTGAAATAGGAAATTTAAAAAATCTAAAAGAATTATATTTAGAAGAAAACCAACTTACGATGTTACCAAAACAAATCGCAGCCTTAAAACA

>NZ_CP011934|4|4|1406068-1406642|CRISPRCasFinder
AAGGAAATTGGAAACTTACAAAA	TTTAAAAGAATTATATTTAAGCGCGAACGAAATTACAACTCTGCCT
CCTGAAATAGGAAATTTAAAAAA	TTTACAGGTGTTATCTTTAAATGGAAACAGACTTGAAACAATTCCT
AAAGAAATTGGAAACTTAAAAAA	ACTAAAAGAACTGTCGATAGAATGGAATAAACTTCAAACACTTCCC
AAAGAAATTGGAAATTTAAAAAA	CTTAAAAGAATTATATTTAAGCAGAAATCAACTCAAAATATTACCG
CAAGAAATCGGGAACTTAAGAAA	ACTACAGCGTATGCATTTAAGTACAAATGAACTCACAAAACTCCCG
CAAGAAATCAAAAACTTGGAAAG	TTTATTAGAAATTTATTTATATGATAATCAGTTTACAACACTTCCC
AAAGAGATAGGCAATTTGAAAAA	TTTACGTAATTTAGTTTTAGGCAGAAATCAACTTATATCGCTACTT
CCTGAAATAGGAAATTTAAAAAA	TCTAAAAGAATTATATTTAGAAGAAAACCAACTTACGATGTTACCA
AAACAAATCGCAGCCTTAAAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011934.1\|WP_000802795.1\|1418965_1420948_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NZ_CP011934.1\|WP_000875145.1\|1402864_1403767_-\|SH3-domain-containing-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_001068326.1\|1392787_1393438_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_001158185.1\|1399745_1400840_-\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223260
NZ_CP011934.1\|WP_000068276.1\|1402168_1402633_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000788712.1\|1400896_1401964_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NZ_CP011934.1\|WP_002156631.1\|1405390_1405873_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|238089
NZ_CP011934.1\|WP_000986372.1\|1417337_1418732_+\|flagellar-hook-protein-FlgE	unknown	unknown	gnl\|CDD\|235557
NZ_CP011934.1\|WP_000333681.1\|1393438_1393735_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_001026909.1\|1414935_1416501_+\|flagellar-hook-length-control-protein-FliK	unknown	unknown	gnl\|CDD\|350657
NZ_CP011934.1\|WP_000051771.1\|1408823_1409342_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237855
NZ_CP011934.1\|WP_000477063.1\|1422194_1422491_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP011934.1\|WP_000698134.1\|1410124_1411132_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP011934.1\|WP_001050110.1\|1394445_1395714_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|380169
NZ_CP011934.1\|WP_000993256.1\|1397154_1398654_+\|DUF342-domain-containing-protein	unknown	unknown	gnl\|CDD\|377177
NZ_CP011934.1\|WP_000465522.1\|1407635_1408772_+\|carbon-nitrogen-hydrolase	unknown	unknown	gnl\|CDD\|143598
NZ_CP011934.1\|WP_001115362.1\|1416515_1417310_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236594
NZ_CP011934.1\|WP_001132141.1\|1395814_1396861_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223477
NZ_CP011934.1\|WP_000723319.1\|1412202_1412802_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|310150
NZ_CP011934.1\|WP_000371211.1\|1413162_1413873_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011934.1\|WP_000802795.1\|1418965_1420948_+\|GAF-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	3.83005e-25
NZ_CP011934.1\|WP_001158185.1\|1399745_1400840_-\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|223260	COG0182, COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis].	6.51899e-149
NZ_CP011934.1\|WP_000788712.1\|1400896_1401964_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	2.78462e-17
NZ_CP011934.1\|WP_002156631.1\|1405390_1405873_+\|sulfurtransferase	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	1.2689e-15
NZ_CP011934.1\|WP_000986372.1\|1417337_1418732_+\|flagellar-hook-protein-FlgE	gnl\|CDD\|235557	PRK05682, flgE, flagellar hook protein FlgE; Validated.	1.58159e-151
NZ_CP011934.1\|WP_001026909.1\|1414935_1416501_+\|flagellar-hook-length-control-protein-FliK	gnl\|CDD\|350657	cd17470, T3SS_Flik_C, C-terminal domain of flagellar hook-length control protein FliK and similar domains. The flagellar hook-length control protein FliK is a soluble cytoplasmic protein that is secreted during flagellar formation. It controls hook elongation by two successive events: by determining hook length and by stopping the supply of hook protein. It contains an N-terminal domain that determines hook length and a C-terminal domain that is responsible for switching secretion from the hook protein to that of the filament protein, by interacting with FlhB, the switchable secretion gate.	1.0888e-12
NZ_CP011934.1\|WP_000051771.1\|1408823_1409342_+\|hypothetical-protein	gnl\|CDD\|237855	PRK14900, valS, valyl-tRNA synthetase; Provisional.	3.33336e-09
NZ_CP011934.1\|WP_000477063.1\|1422194_1422491_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.11406e-10
NZ_CP011934.1\|WP_000698134.1\|1410124_1411132_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.47691e-15
NZ_CP011934.1\|WP_001050110.1\|1394445_1395714_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|380169	NF033161, lipo_LipL41, lipoprotein LipL41. Members of this family are lipoprotein LipL41, as described in Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 but found broadly in the genus Leptospira. Close homologs that are not lipoproteins by sequence are likely defective in their reported coding region.	2.11993e-12
NZ_CP011934.1\|WP_000993256.1\|1397154_1398654_+\|DUF342-domain-containing-protein	gnl\|CDD\|377177	pfam03961, FapA, Flagellar Assembly Protein A. Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.	4.73847e-105
NZ_CP011934.1\|WP_000465522.1\|1407635_1408772_+\|carbon-nitrogen-hydrolase	gnl\|CDD\|143598	cd07574, nitrilase_Rim1_like, Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases). Some members of this subgroup are implicated in post-translational modification, as they contain an N-terminal GCN5-related N-acetyltransferase (GNAT) protein RimI family domain. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 12. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	1.81048e-19
NZ_CP011934.1\|WP_001115362.1\|1416515_1417310_+\|hypothetical-protein	gnl\|CDD\|236594	PRK09618, flgD, flagellar hook assembly protein FlgD.	4.64168e-30
NZ_CP011934.1\|WP_001132141.1\|1395814_1396861_+\|hypothetical-protein	gnl\|CDD\|223477	COG0400, COG0400, Predicted esterase [General function prediction only].	0.00803297
NZ_CP011934.1\|WP_000723319.1\|1412202_1412802_+\|hypothetical-protein	gnl\|CDD\|310150	pfam05345, He_PIG, Putative Ig domain. This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.	0.000396972

>NZ_CP011934.1|WP_002156631.1|1405390_1405873_+|sulfurtransferase
MAKENDFVKTKRNPIPNRLIDYKKFQNIVNSSAEEREAKRLTEEEFLNMIQDKEVVLLDARSESRYKLRHIKGAVSLPFTEFTKESLAKVIPKINSKILIYCNNNFTGSPEAFASKAPAASLNLSTFISLKAYGYKNIYELGPLLSVDSTKLIFEGTEVQ
>NZ_CP011934.1|WP_000875145.1|1402864_1403767_-|SH3-domain-containing-protein
MKYILSSIGFVLFLIGNNLISAEIESCFTSYPEVVVRDFPNTSGKKVRIIKQSIPLKILERTSTLEEIKIRNRKVQSNWVKISDGWIFGGLIQCIPKIFFAHPISYHEEELPFSPSDSTNWIAIYLQQESYLRKQISIDLKREHDTVVDQNENIKTGYKVNVINNPIVLIKGITFKKGNFPAITKKVPLELEFGKSYHFNFEKDNYRITSKGKPVQSSGINGYQLILHKNNEEMIIDSRVYRTEKPILVFAGDIDGDGELDFIFDLKDHYNVSNEHLYISSEKINDFFIVPVAANWNTGC
>NZ_CP011934.1|WP_000068276.1|1402168_1402633_+|hypothetical-protein
MAQNKKSALFDILKREKLEKMLKRNSSSGQSQSNEKPQTSVSENVPDKSSTEKKEPQISKIYKAIEDVKLDIRYYFLQDEYVEKLASIYIKNEGPLEKLGIDPKKYLEYARDSFDRYKQLDKKMPLEPMNKKSWDHVEKSLNELITKLLEKFSK
>NZ_CP011934.1|WP_000788712.1|1400896_1401964_+|rhomboid-family-intramembrane-serine-protease
MKNHSPSPGECGNPGQICPGLALLDSLTTIRILSNMAKRKYRNGISLFGYSIFHPINLILIVNVLVYILQLFAGGTGIIEYYFALTPFRVFHGHYWQVFSYGFLHEAYGIPFIHLFFNMYVFVMFGGLICRYVSAWKFTVVYLTAILTGGITVLLAPVLNEILGIHYPMDLFQTTTLGASGGVTGILVLFGILFPETEVFLVFFRMKARYAAWIFVGGGFVADFVAVYYFHSPFVVSNSCHLGGAIGATLVAPLILKNNFGKIFPKNKDSENTKPTRSLNEDLDFQAQKNLKLLDELSKKISYSDQEDILIPLQQTNVNLCPPPTFQPEDPFCLRCDWLPNCALRKLKTSSEKTP
>NZ_CP011934.1|WP_001158185.1|1399745_1400840_-|S-methyl-5-thioribose-1-phosphate-isomerase
MQESGLKPILWKNKELILLDQRVLPGTTSYITAKTLEDCIFAIREMVVRGAPAIAITGAFGITLYWNSLVSKPSFSELKLKLSELLESRPTAVNLRLAIEEFSSRFPESNYSSFSLEEIQKGAEELALFMLSEDLENNLTLSKYALSLFPKQPSSLNIITHCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELQEEKIQSFLITDNMAGWVMSSRKIDAVIVGADRIASNGDTANKIGTYPLAIVAKHHGVPFYVAATAKSMDFRIPNGSYIPIEMRKEEEITSFGFLKDSDGKPLLKEGVIAPKGMKALNPSFDVTPASLITGIITEKGIVSPVTEENLKKIFQSI
>NZ_CP011934.1|WP_000993256.1|1397154_1398654_+|DUF342-domain-containing-protein
MNANEEPMNTPTPESQISPVSIESAITIVVSTDQLSATITVRPYNLKGTILSKDKLWSVIQDWGIHRDRVLTDEIRKILNLLERAAQKGDFTPIKMEVAKGVAPVPGENGWVRFYHPMSKRVKLLEDGRADFRNIDRYINVKVGEKLAAKFEGIPGIPGFDVFGNIIPAPSIKKPKLVVGNHIEERNVLEEGKNLQEYFASSNGVIFATEVSITVSPELQIAGNVGLSTGNIQFDGNVIVRGDVEPGSVVECTGSLVVYGNLESNQIKVGQDLIVHGGIKGSGTEIILVTGRIQTKFIENSYLETEGDIIVEGAILNSTIDTLGSIILNGQNGNLVSSKIRTNEGISVVSLGSSAELDVIVELGFHFKNDRSFQEISRKIQMGEKEMEKILPKIQQIKHMVQRFRGNLPEDKKIAFKVVFEDYNKKLKILNMLKFKQDSLKSSRFNPGAVRLAVQKGAYPGAVIHYRRQIEKITKFQSSFMMVFEPGQEKAIMVALQTK
>NZ_CP011934.1|WP_001132141.1|1395814_1396861_+|hypothetical-protein
MPMNFFSAIRGFPFLIDYSGLKIPKQAHITEISLDLSGSVSLRTKVLENPGNSKKPVIYLQHGMSFKGIDDVRILALGNNLANRGFRVYLPELTEVKNLLIRSETISNIRASFLKIHALEKCPVSYISASFSAGMGFVALADSECQKVLNSALLIGSYSDFVKTLPFVLKNYEIESYAVNVMMYNYIHLIRSEPEGLKKYFLESALDNGLSRKEDSVQGPKVFLNLNEEDKNFLKRFLESSDFRNQLALEIKSIVPETFAKETSPAFFTNHFYRPCFLLHGDDDPVISPQESKDLRNLLLKDGNQKVSFLETSLLTHGDHRPFYSGLNEILPMAKFWGEYLNSVNLFF
>NZ_CP011934.1|WP_001050110.1|1394445_1395714_+|tetratricopeptide-repeat-protein
MNLKRIFIFFLLLCQLHCATFTGTLVNKWVKDYYESTNITGVGIGLAGDGAISVYMGVQFGLAFGLAYAAATIVALPFIFFGLLQPLKVQPVLYFPVFSNDGKDLKGLLQHVPHVIPFYIRPIVIPSHPKESIERELAKSFFSSVYLSLDDLYSFQYLNQTSTSKILEHTSIEEIRNDMPRFRKLFNEDFVFISEAHLKFGECKLEKISYKEIMKFEGRLLSRPVYPREKEDQEETGLMEVQVEIKTYLVDFKNQKIRSFEISETERGYNDFGQRACPDPIRAGKMALKNVGLSHTRKIFPQWKKTKLNLIRNDSDPNVQKLLEEGFQYFGRGDDENHEIFLIKPEALEVWKLALAQSGNRSEGAFANIAYYYLNNGYLEEAIDWFRKAAVANPDREKFWNLRIKDILHKREQVEVYNDLNN
>NZ_CP011934.1|WP_000333681.1|1393438_1393735_-|hypothetical-protein
MCFYLLYLHCFSSFRFETKTAKDNRGDSTSSAQSLLSSFVSDHVAENSTCGKLEIAEHRTEVDKKSHLVFQVFVIGKSACCPQIILKSELFLNLYRGN
>NZ_CP011934.1|WP_001068326.1|1392787_1393438_-|hypothetical-protein
MNPISIGLLYFFGSIAIGIFLGWIIGNYFRFEVGLMLGIFTPGLTSTFVAIQLFFIEYQARLQPGPNRFIGEADDFVFELLNASLVFMLIAVFLISFMMIFLQNFYTDYLQKTKPELQKKLELGPEEVPKNFLVFLINFIFNIVTFGGIPITFGVYFWKKNLIFGFQIGIGTIAIGILGHAIKALFQRDLSWSFYAFLLCFNFAAWIFALEFFEFM
>NZ_CP011934.1|WP_000465522.1|1407635_1408772_+|carbon-nitrogen-hydrolase
MFFKRSYLFYFLFLILIFYGIWSYTDRSSWEQTPDSRLKRIESFGKNLKKGNLLGIQPWMYPIDYSNEINFSKKIQSYLEEASKKGYINPKTIVVFPEYLGTWLVVAGEKTSVVKSDKLEDSMRTLILSNPVSFIFNFFKAQGKDKIRDALFRMKAEKMLSIYSNTFSGMAKKWGVTIVAGSILLPEPYILEGKIQIRNGALKNVSYVFLPDGRVAENSPEKIYPIEDEKSFVAASTLNNLKIIQSPMGKIGVLVCADSWYPEVYEIFKKQNVNFVVVPSYVAPDGAMSEVWKGYNGSKNPTDIRLEDVHRISEGEAWLKYALAGRILKSGATHGMNVFLRGSLWDLGSDGEIILVHRSMVRTFPKIYGASIVNLWLD
>NZ_CP011934.1|WP_000051771.1|1408823_1409342_+|hypothetical-protein
MSLFLFETFSDNFQSKHNEVTSGKWFGLTSLNLEGKPFAAFFEGSLVLKLGAEKIAEIISRYPGAKLFDPSGNNKAMKDWLQIPAEFEQDWLNLAEDALVFAEKSLSAVAVPAKKKAAPKKAAKKKAPAKKKAAPKKAAKKKSSAKKAKMKPKAKAKKKVARKKTAAKKRKR
>NZ_CP011934.1|WP_000698134.1|1410124_1411132_-|alpha/beta-hydrolase
MKILKWILGIIGTFALFLVVTFYAETPKYEYKSVPLYSNFDSYYREKLQISRSKKVRPGNEEKLVRYSADKTDFSILYIHGFGASRAEGEEVTDQLAKDFKANLYYVRLPGHGTNLENHRDTTFEEILQDSETAFLECEKLGKKTILIGTSMGGLISTYLAAKYPEKVHALVLVSPFYDFTNPFSVIYQFSWGKDFANIVMGKIRKSTEEEKRNPASAFWYRDQYLAAVQNLSDLREFILGTDPFSKISSPTLLFYYYKNEKNQDVSASVSSMLNAFKKVNENGKASPLNKAVKVEFGNHVLFSKYMKSDKDLILKETETFIQNVFSLNKNLSHN
>NZ_CP011934.1|WP_000723319.1|1412202_1412802_+|hypothetical-protein
MKKIMLILLLFCLVFASCEDEKKDEGSITGNSIMDLLLLQEVSTPPCPGGVTMMDIPSTINAQVGTSVKSPFSIQFSAGSVNHETLMKNKNCNFSELSVTNLPAGLTLNSTTGAINGAPTAISAATTVTFSAKLKANNSTPITFTKTTTVTIFAAGSLTCNTAGAALGCNNAALPYSCPNSNFCYSTYSSCKAASECGY
>NZ_CP011934.1|WP_000371211.1|1413162_1413873_+|hypothetical-protein
MDPFEKIVNRYGGWELWNRLDFVEFYFQSLSGPLPFLKGLGKTFNKHGKVRVFPKEFITEFLDYPNPGKKIIFKNGKVGIVNISENLSEFGLSNYRDSFSGLKKYRLWNPLDVSYFFGYATTQYVSIPFILKEYSVRKFELENGDFQIEAEFPSYLHTHCKKQSYRFDSEGLLIRNDYTADIVGSWAKGAHFTTHFQDIEGFPMATKRDVFVRLGSWATSIPVLSAELKPLGVYFR
>NZ_CP011934.1|WP_001026909.1|1414935_1416501_+|flagellar-hook-length-control-protein-FliK
MNISGDLSVSEFKPQQSMRSLPKMGEVAGKNSFVELMKFLQGSAQKGLEETLAEIQNTSSKAELPQLEEEDPEIIEEKKRRSINSIEEEISKEENFETTQEAPNANILPWFLVSETKTNESVDPEIESVILDELQSEIIKTNSTETLNAPESISTSELIENFFANEVEESTKLLSEVSLKEELENLLDTEKGSLVSFENLKEIKARSTKQESEIYEKSESFEANDSSDTFRFNEVDKKESKENIKGLSNSFKDKDFEEAKVEVSKELALDSEKWKISRDKKTDSYTNLKTAAKEEIKAVVLNQFTENSFGKSGQEQSFRSDSYSSLVKGVGTTAANGSRESGTFSKEFLPSKESNVLSKKDIQQNFQNLIRSARVQILENGRTEASIRMNPKDLGQMSLAISTDKDVVRGKLLVESDTVKQQLVAELANLKQDLKANGLELESLVIEVKEREEGFSFNADSDKNGKDSHSFQAAFGEDWNSDFKNSFYEEDELSFEENFSEPNDFPKKTDGKSEKLLDLKV
>NZ_CP011934.1|WP_001115362.1|1416515_1417310_+|hypothetical-protein
MPETTGISQQANINRYLEGDRSFNIRNHMENLEKEEKNGLKGIEIRSTVKSLGKDDFLKLLITQLSSQDPTNPVKDQDFIAQMAQFSSLEQMNNISNGIQKMGNRQSFSLVGKLVSGPDFVNGENIAGIAGALFFDGEGKTFVRVNGRSIDVEQISLISDPVVLKEQEAAYNQSQSQQSVLARTPAHSSEIGTNVSPQEAPFDISSNAHEMATKQKSMESSIKNQKEVEVPGTEQTPELQEKTTSEKKISDWKFPGKDKSNSYE
>NZ_CP011934.1|WP_000986372.1|1417337_1418732_+|flagellar-hook-protein-FlgE
MMRSLYSGVSGLKNHQVRMDVIGNNISNVNTHGFKTERVTFQDMISQELRGASEPKENIGGVNPQQVGLGSLIAAIDKIMTQGSLQTTGKNTDVAISGEGFFIVKDGDKQFYTRAGAFNLDKNGYYVNPANGLKVQGWNSRLDDKGNKYINSAASIEDIIIPVYSKEPARATSQIDFKSNLNSSAPAVPPDATQEEITAMINDPDPKMRRGHVTTINTFDDQGIQREFKMEFYKVRDNTWKARLSMTDSTQLSVDVSGTGGQNTQLPGNTELEFGFTPDGKLVYVSDGVDSMNSGKLNAKVSFRIPGNPAIQNFDLNLGEAGMVNGITQFSSDFTTKAVKQDGYTMGYLESFSIDNSGTITGVFSNGVRQPLARVATAVFNNPAGLDKAGDTMFSYSMNSGEPNIGEAGVQGRGKINAGLLEMSNVDLSDQFTDMIVTQRGFQANSRTITTSDQMIQEVLGLKR
>NZ_CP011934.1|WP_000802795.1|1418965_1420948_+|GAF-domain-containing-protein
MKPKFPKYIVTDLDSIVKRLDPIISRLEIEFLDFKEFFQSELFRNSSGFLNVIFYLTVSDLKKTQKEIHQQFQRNPLILSRFILNENLDYVHSEDLKIEEELIFSVLPEPSSDMVFNKTFLNAFTQLQMITDQFDLQHKVNTTKYEISKLTRVGISLADEKDINKLLREIIFSAREIAIADSGSLYLVEKDELGLVRNLRFKISSMDIDTEEFLLPINKSSVAGYVAATGKILNIPDVYNLPEDSEYKFNRNFDVLSNYHTKSMLVVPMKNHRNEVVGVIQLINKKRNFNQKLTLEQMRGNDVFPFDDYSAQLVMGVAGQAAVAIQNNHLLQEIEALFEGFVTASVNAIESRDPTTSGHSFRVAVLTVGLAETVDLIREGKYKNTKFSKEQIKEIRYASLLHDFGKVGVREKVLVKSKKLEDYELELIRWRFEYIKKDIESRILQKKTDYLKKHGAVGFADYETSLEFELRVEYQKLDQMFQIVVDSNEPSILEESNFQKLEEIAKVNYSTTGGEKLSLISPYEFGFLTIKKGSLDFAERKEIESHVEHTFQFLSKIPWTGDLKMVPSIAHAHHEKLDGTGYPRGLTADSIPIQSKIMAISDIFDALTDKDRPYKRAVPIERALDILQMEARENHVDQDLLKIFIEGKVYDKLYYSGYLR
>NZ_CP011934.1|WP_000477063.1|1422194_1422491_+|helix-turn-helix-transcriptional-regulator
MFKSLHSREAKIFCKNLIAARKDAHLTQLEVANRLGEPQSYISKIESGERRLDVVEFWRIFKILGKSLEFYFQFDDKHEGFEKKSKTIKAASSRRKKK

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Crispr_ID: NZ_CP011934_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011934_5

1521509-1521713

Orphan

Consensus_repeat	Method
GTAGCGTAGACTTTTGCTTTCAACGGAGTTGTAAAAATCATCGCTTTCGTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011934_5

>merge|NZ_CP011934|5|1521509-1521713|CRISPRCasFinder
GTAGCGTAGACTTTTGCTTTCAACGGAGTTGTAAAAATCATCGCTTTCGTAAAAAGCGATGTTGCAAAAAGACAAGCGTAGCGTAGACTTTTGCTTTCAACGGAGTTGTAAAAATCATCGCTTTCGTAAAAAGCGATGTTGCAAAAAGACAAGCGTAGCGTAGACTTTTGCTTTCAACGGAGTTGTAAAAATCATCGCTTTCGTA

>NZ_CP011934|5|5|1521509-1521713|CRISPRCasFinder
GTAGCGTAGACTTTTGCTTTCAACGGAGTTGTAAAAATCATCGCTTTCGTA	AAAAGCGATGTTGCAAAAAGACAAGCGTAGCGTAGACTTTTGCTTTCAACGGAGTTGTAAAAATCATCGCTTTCGTAAAAAGCGATGTTGCAAAAAGACAAGC
GTAGCGTAGACTTTTGCTTTCAACGGAGTTGTAAAAATCATCGCTTTCGTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011934.1\|WP_000623985.1\|1533654_1535118_+\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	unknown	unknown	gnl\|CDD\|227111
NZ_CP011934.1\|WP_000492795.1\|1528730_1529549_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000141324.1\|1520717_1520945_-\|DUF1858-domain-containing-protein	unknown	unknown	gnl\|CDD\|274898
NZ_CP011934.1\|WP_000249633.1\|1510077_1511640_-\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326
NZ_CP011934.1\|WP_000693606.1\|1522678_1523683_-\|sulfate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224529
NZ_CP011934.1\|WP_000568847.1\|1535114_1535615_+\|biotin/lipoyl-binding-protein	unknown	unknown	gnl\|CDD\|133459
NZ_CP011934.1\|WP_000825588.1\|1531371_1532481_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000831279.1\|1527444_1528734_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_001068702.1\|1532860_1533658_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|223282
NZ_CP011934.1\|WP_000900432.1\|1514534_1516478_+\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NZ_CP011934.1\|WP_000672052.1\|1519675_1520419_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000465997.1\|1521072_1521483_+\|6-carboxytetrahydropterin-synthase	unknown	unknown	gnl\|CDD\|376501
NZ_CP011934.1\|WP_000575569.1\|1511831_1512854_+\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|237562
NZ_CP011934.1\|WP_000371582.1\|1518403_1519186_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000599731.1\|1514020_1514533_+\|rod-shape-determining-protein-MreD	unknown	unknown	gnl\|CDD\|274574
NZ_CP011934.1\|WP_000801434.1\|1516464_1517970_+\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NZ_CP011934.1\|WP_000127192.1\|1530345_1531227_-\|DUF2225-domain-containing-protein	unknown	unknown	gnl\|CDD\|378340
NZ_CP011934.1\|WP_000739014.1\|1523711_1525541_-\|alginate-export-family-protein	unknown	unknown	gnl\|CDD\|372583
NZ_CP011934.1\|WP_082269051.1\|1529551_1530349_-\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NZ_CP011934.1\|WP_000964329.1\|1512926_1514024_+\|rod-shape-determining-protein-MreC	unknown	unknown	gnl\|CDD\|237560

Protein	Function_ID	Function_description	E-value
NZ_CP011934.1\|WP_000623985.1\|1533654_1535118_+\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP011934.1\|WP_000141324.1\|1520717_1520945_-\|DUF1858-domain-containing-protein	gnl\|CDD\|274898	TIGR03980, conserved_hypothetical_protein, hybrid cluster protein-associated redox disulfide domain. Members of this protein family resemble the domain of unknown function DUF1858 described by pfam08984, but all members contain an apparent redox-active disulfide. In at least one member protein, a cysteine in the CXXC motif is substituted by a selenocysteine. Most member proteins consist of this domain only, but a few members are fused to or adjacent to members of the hybrid-cluster (prismane) family or the nitrite/sulfite reductase family. [Energy metabolism, Electron transport].	1.06335e-17
NZ_CP011934.1\|WP_000249633.1\|1510077_1511640_-\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	1.88115e-130
NZ_CP011934.1\|WP_000127192.1\|1530345_1531227_-\|DUF2225-domain-containing-protein	gnl\|CDD\|378340	pfam09986, DUF2225, Uncharacterized protein conserved in bacteria (DUF2225). This domain, found in various hypothetical bacterial proteins, has no known function.	6.00995e-67
NZ_CP011934.1\|WP_000568847.1\|1535114_1535615_+\|biotin/lipoyl-binding-protein	gnl\|CDD\|133459	cd06850, biotinyl_domain, The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.	1.69168e-26
NZ_CP011934.1\|WP_000900432.1\|1514534_1516478_+\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP011934.1\|WP_000693606.1\|1522678_1523683_-\|sulfate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224529	COG1613, Sbp, ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism].	0
NZ_CP011934.1\|WP_000465997.1\|1521072_1521483_+\|6-carboxytetrahydropterin-synthase	gnl\|CDD\|376501	pfam01242, PTPS, 6-pyruvoyl tetrahydropterin synthase. 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.	7.99295e-37
NZ_CP011934.1\|WP_000575569.1\|1511831_1512854_+\|rod-shape-determining-protein	gnl\|CDD\|237562	PRK13927, PRK13927, rod shape-determining protein MreB; Provisional.	0
NZ_CP011934.1\|WP_001068702.1\|1532860_1533658_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|223282	COG0204, PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism].	1.6769e-09
NZ_CP011934.1\|WP_000599731.1\|1514020_1514533_+\|rod-shape-determining-protein-MreD	gnl\|CDD\|274574	TIGR03426, shape_MreD, rod shape-determining protein MreD. Members of this protein family are the MreD protein of bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. It is highly hydrophobic (therefore somewhat low-complexity) and highly divergent, and therefore sometimes tricky to discover by homology, but this model finds most examples. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	6.58697e-07
NZ_CP011934.1\|WP_000801434.1\|1516464_1517970_+\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	5.93069e-65
NZ_CP011934.1\|WP_000739014.1\|1523711_1525541_-\|alginate-export-family-protein	gnl\|CDD\|372583	pfam13372, Alginate_exp, Alginate export. This domain forms an 18-stranded beta-barrel pore which is likely to act as an alginate export channel.	8.20967e-18
NZ_CP011934.1\|WP_082269051.1\|1529551_1530349_-\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	2.91193e-95
NZ_CP011934.1\|WP_000964329.1\|1512926_1514024_+\|rod-shape-determining-protein-MreC	gnl\|CDD\|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	4.05585e-52

>NZ_CP011934.1|WP_000465997.1|1521072_1521483_+|6-carboxytetrahydropterin-synthase
MFFQESGRFYIRIEERFESSHYLYKYFPDGSDEPIHGHSWKVELYLSGKKNIGDDGISFDFLTSKQKLKELVGRLDHILINDLEEFKKINPTSENIARWFYHYLKESVHTAGGKVDRIVIHEGPENLAFFEPTSLS
>NZ_CP011934.1|WP_000141324.1|1520717_1520945_-|DUF1858-domain-containing-protein
MTEVVKPRFYKEMTVGEAMAVHPEAGLVFSSYHLGGCSHCSINELETIEQVCMGYGVEVDVLVESLNNLLEDSED
>NZ_CP011934.1|WP_000672052.1|1519675_1520419_-|hypothetical-protein
MKFRFQKLGSIFVCIFYNLFFSFVSLEAITIEVFIPLCDDKSLVCGKGKAGDPRSLEENLYWGAAFGAETFFKRNSNFKILEIKERKLDSPILRTLIIEKKRKQNETYTKLIIYAYAGDKIDNALLDFLNASSGKSPADIIVWSGHNRLMDRIPPKLQSQSAKTVAVLACESEKYFDSVLRSIGAKPIVLTKTFMAPEAYLLEALTETVSKFGAEDKKSIRSAMIRSYAKYQKISLKAAGSVFSKLE
>NZ_CP011934.1|WP_000371582.1|1518403_1519186_+|hypothetical-protein
MDPVKDSRFFFDLKRKFEVILEEVEKKTFDQKDEIRELESLWEEMFELAGKNDSPYFQIRLKNLKKQLETFVKNKGYEKQEFDRIYHQLGKMKQNDSVEFLDESLRNRLERIAQKHYSPGDMTSSEVVATSKKGKYYITFRCGTIYFITDWSSYTVLKDLDRRKNTVEYKGSVYRIFPSAFVYGLSEEEYRNENFLTMNLLVLKRESGLEFYRFDTLGEILQINEGTFLKGLKPIESSEMDKRIRNYFRKAGIRYYYIPV
>NZ_CP011934.1|WP_000801434.1|1516464_1517970_+|rod-shape-determining-protein-RodA
MKPDKSIEKIDYFLVISVVIVVLCSVTTLYSQEVNFEDGPGKWYRQLFYFIIGLAIMYFVSRVNYQLLGAYALVIYVFTVFLLMITLIPGIGYLPSGRGARSWIKLGPVGIQASEFAKLSTVILLGQFMVLKEKDMRNLVVLSIPFIIVIVPMIFILLQPDFGTAVSFLPILFTMLFLGGADILHIGSLLAFGGITLMVPMFVEYSKLTLINDISDFLQRTGKTDLLSVVNRLGGKIWLALDGKDVKAANLTPKTLNALQEVVDQVVEVEGGFFFKIFSNQKLLLTFGALFLIASIVMVGIRIARGSKTLRQYYIPLGILGISLISAVVVMKTVPFRENQVIRLTAFLNPEEFKQGAGYHLRASKPAVGSGRFFGKGLMNAEMTEGRIPHVPESSTDFIFASWAEQTGFLGSVFLLFFLFSIPLRGLQISYESKDRFGSLLASGIVALLFYHMAINIGIVIGLMPVTGIPLSFMSYGGSHLVMSMTAVGIILSIKSRKHAN
>NZ_CP011934.1|WP_000900432.1|1514534_1516478_+|penicillin-binding-protein-2
MLGGAQSASEYRLEKSFRLRLYTFSGLVVFALAAFIFQLFNLQILNGTDNALKAEKFVRKSEIMPAARGQMFDRNFLTPETSMALVSNYSSLDVVLNTSLFKYDPTSVKAFIQEFARTLSIPISYYQDELIEPRFSRNLKAKKPIVLLEGISTAQQERISVFDNISKYIVLLPSPRRVYKMGPALAHVTGYIGKPTRDDLVSGKIKSYQYLGKDGLELEYDSELRGVDGFRIQKRSSEGNIEEERVVEHSSPGNNLVLTIDKDIQIAAYKALKGSRGTAIAIKVATGEILAMVSNPSYDPNILSGKNRADRTAHFKRVKDNGGFLNLAIKSKFPPASTYKTLVALAALESQHKIGYTPETTFSCNGSFVLKSTFAGVPDQVFLCWEKGGHGTNDLAHALQKSCSVYFYNLGYKLGSDAILNYSRLFGLENKSKVDLPDETAGFVPSSAWKKRTYGTKWFDGDTINLSIGQGFISTTPIGMALFYMGLLNRGQIYQPYVVSEIRDPVDNSIINRTTPQILRDIPINQSSVEAIKEGLKLVVKSGTAAHVLNKPFLPEIAGKTGTAQTRRRGASGSNHAWFVGYAPANAPASEQVLVVVFVEYGIGGAAGAAPVAREMFHAAFPPGTFKKTQEVNPQPKIGQEGTLEAR
>NZ_CP011934.1|WP_000599731.1|1514020_1514533_+|rod-shape-determining-protein-MreD
MILEKLVIAIGILIAHFLNGSNLFEIGSAIKPDFMILLVLFFALRRGPLYGLWIGFFGGLLTDSGLGGEISVGNVVTYKIGLHSLTFCLIGYLVGKFARSAYHENYLSITIYSLLITFITRLATYYLFSLFFHENMSYSLFFTSLFNALIAPAFFYALTWIYQLDHMGDA
>NZ_CP011934.1|WP_000964329.1|1512926_1514024_+|rod-shape-determining-protein-MreC
MLWFQLSRSKETLSLLFCILFSILSLTFRSNVIVRGIASFQRVGDVVSGSIDSFGGFFKGAYNKLESFETIRKERDSCVAVMEDYKLLPQDLEKANRENDALRKELKFHSRQKYSSLKAEVLSVRLNSIYRTIIIDKGSDSGIKPYMPVTARAVDQKGAIIEALVGKVIAVTGGSAVVQPLINSNFNMGISMPDTNLWANLSGNSGRGTEALLNYIDSGIIIDPRVFGEYPMGPSEMIQYTESLSKIGKPVYTSGGGGVFPSGIPVGIITEEGPRNGSFKSAYLKPFVRFEMLESVTILLKLPEKWLETWPEGQNITIENPYFGELNFPGEDRLKENQTKTPNTNQTQTNETKNQPSTPNEEDLQ
>NZ_CP011934.1|WP_000575569.1|1511831_1512854_+|rod-shape-determining-protein
MIFDNLYALFSNDMGIDLGTANTLVHVKGQGIVLSEPSVVAVHAATGKVLAVGQEAKRMLGRTPGEIVAIRPMKDGVIADFETVEKMIRYFIAKVHNRTTFVKPRIVIGVPSGITEVERRAVRESAEQAGAREIFLIEEALAAAIGANIPINEPAGNMIVDIGGGTTEIAVISLGGMVIAESIRTGGDEFDEAIIKYLRNQYNLVVGERTAEDIKLTIGNAFPEKKAETMEVRGRDAISGLPRTLELESNEIRKALKEPTDEILDGIKRVLERTPPELASDIVERGIVLTGGGCLLRGLEMYLSKETGVPVFRAENPLTCVVLGTGKYLDELKYIKPGIR
>NZ_CP011934.1|WP_000249633.1|1510077_1511640_-|Ppx/GppA-family-phosphatase
MVQEKPLAAIDLGTNSFHMIIVRVRTNGTFEAIAREKESVRLGNRLQENGPIDPESFRRGIDCLKRFKILAENAGAEIRAVATSALREASNQEDFLENAYQEAGISIDVVSGYEEARLIYFGILQGIPVFDRKIMMIDIGGGSTEILVGHRGNILFSKSFKLGAIRLSEKFFKEETLSNSDVRKCRLYIEEMLLPFRKILRDLKPDLVVGSSGTIQSIAGMILASRGETEEISLNNFSFTSSEFKKIRNLILEADTSKKRSKIPGLDSKRADIIVGGTLILEEIFDLANVSALTVSEFALREGIVYDTIRKWEHFENTEHSKHLDDIRQTAVHNFMKSFSRDEEFSKHVAELSLQIFDQLKSLHKLGQEQRELLEAASLLHEIGQSISHSAYHKHSYYMIRNSEMLLGFTFLEIEIIALTARYHRKNTPKIKHREFNKLAEKNQTLVCQLSAILRISSALNRNRGGLVSSVICKIEKNQIRFILESSKGYDPSLEIWAAEEQKVAFEETFGYSVEFITGT
>NZ_CP011934.1|WP_000693606.1|1522678_1523683_-|sulfate-ABC-transporter-substrate-binding-protein
MKIKFFKITTIVFFTMTSNLGLFAKDITLLNVSYDPTRELYAEYNKLFVSYWKSKTGDEVRVNQSHGGSGKQARSVIDGLEADIVTLALAYDIDIIASKGLISRDWLKSLPNNSTPYTSTIVFVVRKGNPKNIKDWDDLVKSKVSVITPNPKTSGGARWNYLAAWAFAQKKFNNDTNKVQDFIKTLYKNVPVLDSGARGSSNTFAQNGIGDVLIAWENESFLILEEFGKDKYEVVIPSLSILAEPPVAIVEKNADKHGNLETAKAYLKSLYSEAAQEIIAKHGYRPRSQTILKKYETKFPKLDLITVDGHFNGWQKAHKDHFADGASFDQLYVK
>NZ_CP011934.1|WP_000739014.1|1523711_1525541_-|alginate-export-family-protein
MKKNAIFKVSAGALLFCCIIPLNLFSQNSKKEKTNGPVLNLDPPSDVRYEEQPNDGKGIPEIQEELAKEEPYKSPYKGKLPGEFMKSMLLSPEHQEAIRRTDKLWFGDIFRTGFQIRPRFDYSHNADFDKRTQDDRNYATQNSQVFFVVDPNPYVAAKVTIQDVRVFGGEQSRKDGQLGYLGLSNSAGIELSSAPTANNSVSIKNNTDLREGFVQLKNFADGFEIFIGRQIFGFGDNRYVGGRNDGQTGNSFDGARVKYNSKYFNSEAFTSIIAEDSNAGAGNNTANGVKRGTVNDTYLSGLYNTVKFEDFNVDLYYFNVDRKWEQGPNPVTSQDRTRQRDDLNTVGFRLTNRTDNNRLPKTKAWDWTLEASWQYGYNGQRVNAGWDTLKQTVDGNPNSKRIYTERVEYDSKFFIAQTGYTFFDRFRVGIQYSIGSGDPNRTDNKVATYDASFATRSGGFPYFDSGNGIANATFWSNTRTKSIHLMYNSPNYGRFIFVVYDIQKASVNDAWYSSGGTTNTGLTTENPTGAAFGGYKLGEKGGKRLFYEFDLIYQFYLKDYVSIWTGGSYLLAGDAVRNARVNPWAPNINDRYTLDNRAYSFFLFVQFAM
>NZ_CP011934.1|WP_000831279.1|1527444_1528734_-|hypothetical-protein
MKRSYLRFFLILSCFLMFFCKVGDWHGKHSKNPVISTLFNQRMLLLVKGTYATDNPIGFEAYSGGTGQLYQDTSGEGADPAFGLDGVPLAQNLPIFIDIGEIRLSTKYQEGAFDLSLVKNVKDTKSLWDEIAPNRQVFCTIPYTTNSNSCRLNDGEFKAIQFFNGEGVAYPSNDPTSATDWGAFGNGPVQFYYTGLYLRSLVTAWATEPGLTFSNLTLFDNYRVPGINIVPRLSYKPGADATTKSVFPPLVFPVLYKAEKGDQDMLIYPGFDPYILEVRINLKENLMIHSYVSSIGGVRTLVGISDWKPDSDHKGESDMGGGLLVRSRIIRPEKASSLTVLGGTTSTTHYYSVYRLSESEIDTKLPLMASPVQGVSTKMKYIHSGDYRLRCMGDLAKVDGYPETVVRETVFTVPENAPHSEVQVNLTCP
>NZ_CP011934.1|WP_000492795.1|1528730_1529549_-|hypothetical-protein
MFSRCRIFLKPTTLIWFVILPGTLFASPQKPGTFELLGGYQPNWNRLFTEFLPKRTAQTGNLPSSGVISREEEDIENPEETEEDKQEGYQDNRKTEVGVWVGASNPLPGTETQKYLDTTLGGGFFFRIPWPWIFYLEMGAFYANYLSATERALTTIPVYLALGYKIPLDLPISFILRAGGGEAFVVARPSNTSRWDPMMIVGLETSFVAGKKIRIGIRIDYNKIYESRMDAPRETKYPYTSPYEDSRLSNPNYYRVVDTEFFQFGLMVSVFL
>NZ_CP011934.1|WP_082269051.1|1529551_1530349_-|tRNA-pseudouridine(38-40)-synthase-TruA
MNYALLVEYDGLCFHGFQTQKGLSSIQENLEKAAKILLKEEIHISGAGRTDTGVHARGMIVNFKTQRVIQNFSKFLLSLNAITDSGLSILSMTEVDENFDSRFSCNSREYEYWILNTKYPRPTWKNRTFWYQHRIDVPRLEAELELLKGEHDFRSLAKVASLKGRSTVRTILDVKLERSLELEGLLKVKIRANGFLHNMIRILTGTLLEISNGKRKDTNVLEILSSKDRTIAGITLPPYGLYFIRAYYDSYPKIDFMYSHLDFLK
>NZ_CP011934.1|WP_000127192.1|1530345_1531227_-|DUF2225-domain-containing-protein
MTASALAQGKKISFRAKEDTVCPICNEVHQKENMFQGGGRLIAGKLTIELRRLYEKNKKFGRVSPNDYVISVCPRCLYSSFSKDWSTLDAEEIEKVRSQFDTRRSNLEKILGPLDFYQDRNLVLGAASYLLAIECYQNRKATVAPTPKKAVCSVRGAWYFEDLNNDFPNMGFDKVRDLLYQKAAGWYTETMEIMQSGSEPVDQASYILGPDTDKNWAFDGVIYLSAYLTMKFRDELAPDPAAKLNLLVRAKRTLSRLYGSGKGSKSKPSVIIDMAKELYDEYSKLIEEMGGEK
>NZ_CP011934.1|WP_000825588.1|1531371_1532481_+|hypothetical-protein
MKRLILISILISILPVSVFGEAVSSKAYKKRVELLLYLRAIEPIVRNYKGEVPGGQNQQNTGATAANNQQTGGAPEQDGDRVKKYKELKRLYQEGLQYFFENNHVNAYRRFLEAQLGTEMLLEELSQFYVERTEEILKSAIERKNPNNPEDRNLVDIAIEWSKNSFIVRDMTANREAPLTRRMYNPRDFHYVTNKYAIEKNMEMGYKFLGLAKETRNNALKIEKHLEKHQKLQPSHRKHRIEHYIAAIQLCRDARANAINIFKLKYPYDNYYLFKSDAKTEAIKDDEGKAGPSEPVSLNGVTYDFSQNPTLEYDHRMSPVFDRRIPEEYRRDAVDILEKIYDDEVKNRIFLKWDQEKRKQLMGDKAPNK
>NZ_CP011934.1|WP_001068702.1|1532860_1533658_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MNPLKFMESRLGRFPKSYRKIVLKTYLITIVLVFSFAFPSLVAGLFFALIGNQKRKNASFLKGSAVWADAIIWMTKTRFFKIGDFQIPPKGHMIFSNHVNELDFPYDCLVINKPYLANQVIKKTLIAYWWMRAMGSQVFETTKAATIAVSVRNVLKGLDTTSFVVYPEGHNSYREEIQPLQKGMIKLAWENKIPVAIVLKSGLTGYQTLEKGFVVAYKQAGIYDPTQYSSWEEFKDFIFETMDREKKALDSMLSSEVQKESVLVS
>NZ_CP011934.1|WP_000623985.1|1533654_1535118_+|acetyl-CoA-carboxylase-biotin-carboxylase-subunit
MISKLLIANRGEIAVRVIRTCKKLGIKTVAIYSDADRDSPHVKLADESVYVGEPSPTSSYLNISNILEAIKKTKTDAVHPGYGFLSEKSEFAKALEKENVLFLGPSPESMELMGDKINSRIKMEASGVPVVPGYNGQNQDPKILQKEAEKIGYPLMIKATAGGGGKGMKRVYKSEEFLSALESAQREAQKAFGDGTVFLEKYVETPRHIEVQVFGDKHGNVMHLFERECSIQRRHQKVIEESPAPNLPISLRDEICRVAVKAAQSIGYVGAGTVEFILGRDSKFYFLEMNTRLQVEHPVTEYITGQDLVEWQIRVAEGKKLSELTKGKTVIQNGHAIEARIYAEDPENNFLPSTGILEYIEFPDREFLRVDTGVETGSEITVYYDPMIAKMIAWGKTREECTARLKESIDSTVIFGPVTNTFYLSGILSHEEFKKGNTHTHFLEEQTILFTPEKDVQADAFSFAAAALSEKKKSQGIWEAVGPGGFW
>NZ_CP011934.1|WP_000568847.1|1535114_1535615_+|biotin/lipoyl-binding-protein
MIEENFRFRHREEEIPVRVRSGSPGDVSVSITLGGVVHDFRISRNFQSEGNGLFSGPGNHWRILRKGNQIFIHHKGWNTKVLLSNREIHLEEGSGGLIKSPMPGKVIRIGVSVGTTVKKGSVLAIVEAMKMENNLLSPGDGIVEEVLVKEGNMVSQDDVILKLNLG

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Crispr_ID: NZ_CP011934_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011934_6

1647741-1647841

Orphan

Consensus_repeat	Method
GAGTTCCCACAATTTACACGAGATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011934_6

>merge|NZ_CP011934|6|1647741-1647841|CRISPRCasFinder
GAGTTCCCACAATTTACACGAGATCAAAAATCTTATGGGAGTTCCCACAATTTACACGAGATCAAAAATCTTATGGGAGTTCCCACAATTTACACAAGATC

>NZ_CP011934|6|6|1647741-1647841|CRISPRCasFinder
GAGTTCCCACAATTTACACGAGATC	AAAAATCTTATGGGAGTTCCCACAATTTACACGAGATCAAAAATCTTATGG
GAGTTCCCACAATTTACACAAGATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011934.1\|WP_000393533.1\|1651609_1652890_+\|flagellar-biosynthesis-protein-FlhF	unknown	unknown	gnl\|CDD\|183703
NZ_CP011934.1\|WP_000137385.1\|1646440_1646704_+\|flagellar-biosynthesis-protein-FliQ	unknown	unknown	gnl\|CDD\|235567
NZ_CP011934.1\|WP_000418458.1\|1657658_1658711_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000412863.1\|1649439_1651557_+\|flagellar-biosynthesis-protein-FlhA	unknown	unknown	gnl\|CDD\|376386
NZ_CP011934.1\|WP_002158576.1\|1645640_1646444_+\|flagellar-type-III-secretion-system-pore-protein-FliP	unknown	unknown	gnl\|CDD\|235566
NZ_CP011934.1\|WP_001239630.1\|1657259_1657613_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000077420.1\|1658710_1658992_+\|DUF370-domain-containing-protein	unknown	unknown	gnl\|CDD\|179823
NZ_CP011934.1\|WP_000371638.1\|1652917_1653832_+\|MinD/ParA-family-protein	unknown	unknown	gnl\|CDD\|349758
NZ_CP011934.1\|WP_000503780.1\|1643725_1644790_+\|flagellar-motor-switch-protein-FliN	unknown	unknown	gnl\|CDD\|236154
NZ_CP011934.1\|WP_000039671.1\|1654439_1655240_+\|RNA-polymerase-sigma-factor-WhiG	unknown	unknown	gnl\|CDD\|235770
NZ_CP011934.1\|WP_000057946.1\|1642830_1643157_+\|DUF971-domain-containing-protein	unknown	unknown	gnl\|CDD\|377616
NZ_CP011934.1\|WP_001202903.1\|1639313_1640180_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000535110.1\|1655265_1657251_+\|FapA-family-protein	unknown	unknown	gnl\|CDD\|377177
NZ_CP011934.1\|WP_082280300.1\|1658988_1659570_+\|guanylate-kinase	unknown	unknown	gnl\|CDD\|173199
NZ_CP011934.1\|WP_000167664.1\|1636974_1637760_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NZ_CP011934.1\|WP_000938824.1\|1640242_1642468_+\|phosphatidylserine-decarboxylase	unknown	unknown	gnl\|CDD\|234591
NZ_CP011934.1\|WP_001162071.1\|1637766_1638963_+\|sterol-desaturase-family-protein	unknown	unknown	gnl\|CDD\|225546
NZ_CP011934.1\|WP_000455610.1\|1646710_1647490_+\|flagellar-biosynthetic-protein-FliR	unknown	unknown	gnl\|CDD\|376520
NZ_CP011934.1\|WP_001053203.1\|1653835_1654312_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000670460.1\|1644786_1645608_+\|flagellar-biosynthetic-protein-FliO	unknown	unknown	gnl\|CDD\|274610

Protein	Function_ID	Function_description	E-value
NZ_CP011934.1\|WP_000393533.1\|1651609_1652890_+\|flagellar-biosynthesis-protein-FlhF	gnl\|CDD\|183703	PRK12724, PRK12724, flagellar biosynthesis regulator FlhF; Provisional.	0
NZ_CP011934.1\|WP_000137385.1\|1646440_1646704_+\|flagellar-biosynthesis-protein-FliQ	gnl\|CDD\|235567	PRK05700, fliQ, flagellar type III secretion system protein FliQ.	3.39933e-22
NZ_CP011934.1\|WP_002158576.1\|1645640_1646444_+\|flagellar-type-III-secretion-system-pore-protein-FliP	gnl\|CDD\|235566	PRK05699, fliP, flagellar biosynthesis protein FliP; Reviewed.	1.98827e-106
NZ_CP011934.1\|WP_000077420.1\|1658710_1658992_+\|DUF370-domain-containing-protein	gnl\|CDD\|179823	PRK04323, PRK04323, hypothetical protein; Provisional.	3.36055e-36
NZ_CP011934.1\|WP_000371638.1\|1652917_1653832_+\|MinD/ParA-family-protein	gnl\|CDD\|349758	cd02038, FlhG-like, MinD-like ATPase FlhG. FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) is a major determinant for a variety of flagellation patterns. It effects location and number of bacterial flagella during C-ring assembly.	5.98389e-100
NZ_CP011934.1\|WP_000503780.1\|1643725_1644790_+\|flagellar-motor-switch-protein-FliN	gnl\|CDD\|236154	PRK08119, PRK08119, flagellar motor switch protein; Validated.	3.82163e-67
NZ_CP011934.1\|WP_000039671.1\|1654439_1655240_+\|RNA-polymerase-sigma-factor-WhiG	gnl\|CDD\|235770	PRK06288, PRK06288, RNA polymerase sigma factor WhiG; Reviewed.	1.34169e-161
NZ_CP011934.1\|WP_000057946.1\|1642830_1643157_+\|DUF971-domain-containing-protein	gnl\|CDD\|377616	pfam06155, DUF971, Protein of unknown function (DUF971). This family consists of several short bacterial proteins and one sequence from Oryza sativa. The function of this family is unknown.	6.01764e-28
NZ_CP011934.1\|WP_000412863.1\|1649439_1651557_+\|flagellar-biosynthesis-protein-FlhA	gnl\|CDD\|376386	pfam00771, FHIPEP, FHIPEP family.	0
NZ_CP011934.1\|WP_000535110.1\|1655265_1657251_+\|FapA-family-protein	gnl\|CDD\|377177	pfam03961, FapA, Flagellar Assembly Protein A. Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.	1.04939e-140
NZ_CP011934.1\|WP_082280300.1\|1658988_1659570_+\|guanylate-kinase	gnl\|CDD\|173199	PRK14737, gmk, guanylate kinase; Provisional.	3.52318e-106
NZ_CP011934.1\|WP_000167664.1\|1636974_1637760_+\|SDR-family-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	4.80388e-97
NZ_CP011934.1\|WP_000938824.1\|1640242_1642468_+\|phosphatidylserine-decarboxylase	gnl\|CDD\|234591	PRK00044, psd, phosphatidylserine decarboxylase; Reviewed.	4.08255e-78
NZ_CP011934.1\|WP_001162071.1\|1637766_1638963_+\|sterol-desaturase-family-protein	gnl\|CDD\|225546	COG3000, ERG3, Sterol desaturase [Lipid metabolism].	9.08784e-26
NZ_CP011934.1\|WP_000455610.1\|1646710_1647490_+\|flagellar-biosynthetic-protein-FliR	gnl\|CDD\|376520	pfam01311, Bac_export_1, Bacterial export proteins, family 1. This family includes the following members; FliR, MopE, SsaT, YopT, Hrp, HrcT and SpaR All of these members export proteins, that do not possess signal peptides, through the membrane. Although the proteins that these exporters move may be different, the exporters are thought to function in similar ways.	2.34318e-47
NZ_CP011934.1\|WP_000670460.1\|1644786_1645608_+\|flagellar-biosynthetic-protein-FliO	gnl\|CDD\|274610	TIGR03500, FliO_TIGR, flagellar biosynthetic protein FliO. This short protein found in flagellar biosynthesis operons contains a highly hydrophobic N-terminal sequence followed generally by two basic amino acids. This region is reminiscent of but distinct from the twin-arginine translocation signal sequence. Some instances of this gene have been names "FliZ" but phylogenetic tree building supports a single FliO family.	4.72643e-16

>NZ_CP011934.1|WP_000455610.1|1646710_1647490_+|flagellar-biosynthetic-protein-FliR
MEYFINHFQVFLLILSRLMGLLSVAPVFSYPSISVPQKMIFSFLVSVILFPVIAGFLPPVPGDMGSYGLVVIAEALIGILLGFLISLIFAAFQMAGEFFNVQLGFGYAEILDPVTQTSLPVISTLKNLLGMLLFLTLGAYRIMFESLAYSFEKIQVLRFVPEIQNGIYKAMEDAVGAMFFVAFRLSLPVLGIILLVTVSEALMGKAAPQLNILQLSFPIKVTIGLIVMIFITPYLVSQMGAAFDLSFDKVNLMLQEWPK
>NZ_CP011934.1|WP_000137385.1|1646440_1646704_+|flagellar-biosynthesis-protein-FliQ
MTELDVMTLIRDSLYITLKISSPILFTALVVGLIVGILQTTTSIQEPTIAFVPKLLAIFIVIVIFSSWMIQTMTDYTRNLFLMIEKF
>NZ_CP011934.1|WP_002158576.1|1645640_1646444_+|flagellar-type-III-secretion-system-pore-protein-FliP
MKMRHKKFIKSITWIFLLLAGLSLGSTFFTLDAQSAGTRIPIPNLNINVNEAKSPRETSLSLMVLFLVTILSLAPAIVMSLTSFTKIVIVLDFVRRALSIQNLPPNQVMMGLALFMTFFIMAPTLNTVNEKALGPYLEGKIDTNAFFEKGMIPIREFMMRQIGTSGAKDVALFLKIGKVEKVESFDDVPSYVLIPAFMLSEIKKAFWIGIVIFIPFIVIDLVVASALLSMGLMMLPPVMVSLPFKLILFVLVDGWNLIVYELVRSYK
>NZ_CP011934.1|WP_000670460.1|1644786_1645608_+|flagellar-biosynthetic-protein-FliO
MKFLKTSQSNGKKTISVLSLLIIFNFTVISLSAQSERELMDEALKKELGDFSQKKNQETDSGGKKADGSTTNSSTEIKSAQNGTSQSNSSEIQQESNPVEERYRPKDEGPGIAGTLLRVVFILGLLCAALYYILKYVSKNREGRLPVRGEMSVLSSLIIGPNKQLQIVEVSDRLLVLGVADNGINLITEISDPEVKHRILQKKETFQPPEDGFLVTVLEQIKDLNSRISGNTEGPPDSGGGAAREEKRKQARKKLEELKEKTSSLEGGLFDLR
>NZ_CP011934.1|WP_000503780.1|1643725_1644790_+|flagellar-motor-switch-protein-FliN
MGEGSLSQEEIDALLAGASDSFDPGTVAPAATQKEVPGMSPVDRDILSDLLASCFQVAGNTLGAVLSRSSAFLNPNVETKTRKDIESELKSGSFLLYSTLSGSVNGRVVLAMSAENAVKISNSMMGGFDSGELDEAQMQTLRDSLTPVMGALISQISTKTGGGVNGSPSETRNVTSPAALVLPDGETLIRVFFNLTIENIPSFRVQFLLSLSTASDLLNLYRRSGSAGGDMSGMGMGGMGGMGMAPGSMSVKSVAFPNLGTASGASNTPNLNLLMDVQMSVTVELGRTKMYIKDILGLGEGSIIELDKLAGEPVDLLVNGKLIAKGEVVVIDENFGVRVTDIVSPIDRIKPEGK
>NZ_CP011934.1|WP_000057946.1|1642830_1643157_+|DUF971-domain-containing-protein
MAQLSLKATTPDQIDFDENHLKITWKDGVTSIFDLLDLRKRCPCVVCKGGHGGKIGTTTGAIQSIRLYSVNKVGRYAINLIWSDNHQTGIYSYDSLRMFADGLGGELS
>NZ_CP011934.1|WP_000938824.1|1640242_1642468_+|phosphatidylserine-decarboxylase
MLQFHFFQFLDWDLLKFFFYFLSFIGVFLTIRLRFPQLRFLFLAIKIFSGNMDYKGSRGRLVHSQAFFSGTASSLLPGAVIGSALALMIGGPGVLFWIWISSFFIMPLRFVSSTLAIRFRTKTDSGRYLSGPMYFIESALRARWLAVGFAAVGLLTVLVMGGVVPMLYVTHIANRVFEINGMTVPFLLSVILVFIVLGGVRRVGKVSAYLAPIGILLFFLGYFFLFKGSLMNFKDFIWLSFKEAFQPGAAITGGGFALARVYSMASGIFFVSTETGIGKSAGLSGVVRTDYPAKQGLVSMLATFFEGFIISTLVVYALSSYGAFKMEEQLVFLNALFQGNTNPINAAFFVSFLLFGVVSITGWFYTGEQKALYVFGEKFANFFRMLFLFTILAVAYLYVKNGEQILFEAFGLGYSLSIITAVPVLISLVLLEKIARTELKRFLTESGARYEVLKDFYLLILSVVPKNLLSRLFGLLASSRLPRFILIPILKAFARAYKINVDEAELEIQEYNSLNEFFTRALKAEARIIDSADDEMVSPVDAKITGYGDVNQRIIIQAKGVDYNLKELLGGSKYLEDFTNGKYITFYLSPQDYHRIHSPAYGKILGYYYEPGKLFPVNELAVFGIRGLFPKNERLITYLQTEYGKVAVIKVGASNVGRIRVTYDNKIVTNTLIRTARTVEYKEVSIMIGKGAELGRFEMGSTVILLMEKDTFQFNSLTVNEKITYGTTIGKFKKKKCKLPK
>NZ_CP011934.1|WP_001202903.1|1639313_1640180_-|hypothetical-protein
MRATSKIFGILLSVLFFLFCPYSILKAQSSKIKTHSVKPALEIPNPEEENWELGLRAGIGYKGEDRLNSFLRGFTNTYDPGVASKTELDPPKQTTQVELFIRKRIASESQIGFIGGYREWQKFGLKQFSSEPFYTDLKFKISNPYALLMYWHEWNYKRWIFQGGLGAGMSQVYWDSEGYATSGKETFRQEGSLSGTGIEFRLEGAVSRRITESASIQLGIAFSWINIPSLSGTFNGESASFYLRENGSITPLTESDNQTSMLVTNQFSRKLEFQVLTTTLFFGIAQKF
>NZ_CP011934.1|WP_001162071.1|1637766_1638963_+|sterol-desaturase-family-protein
MQGSVLDLAVPFFLILIGFEVLYSKIVGKKVYRWNDTVADLSTGILFSLTGVCVTIFSLWIYEKFRIFCSLQALFGVPEIPLGIPIWPDPVGWHFDFKSLVGWIFVFLAVDFVYYWFHRATHEINFLWACHVTHHSSEEFNLSVALRQSSFQRIFEYMFNLSIAFCGVPWQAFLLAHGILKIYQFWVHTRLVGKLGFLEEILITPSHHRVHHGRDPKYIDKNHGGILVFWDRIFGSFAREEEEPIYGLTKPVTTFDPVYTNVHVYEEIFSLVQKTNNWKEKILLFLKPPGWRPESLGSSVYAEEVDRNRYIKYDPIVSKQRMVLGFLEFLVLTVFSLLLLKYFKSGIFELWKIFPVIVFFFYGFRLTGFVLDGYTIGKARIILFLLVGMILYWILFFV
>NZ_CP011934.1|WP_000167664.1|1636974_1637760_+|SDR-family-oxidoreductase
MTKTAIITGGTVGIGYELSKLIAADGYDLILVARNEKTLKKVKKEIESSNKVKVDILSLDLADPKSPKKIFDFAKKTKAVVEVLVNNAGFGTNGKFDRMDLKEELQMVQVNVASLVELTHLFLQGMVERKNGKILNVASIAGFQPGPNMANYYATKAYVLSFSEAVYEDVKKDGVTVTALCPGPTKTEFFERAEITKSKLLDNPMAPIMEAKEVAEIGYDALKKGKSVVIAGTLNKILAQSVRITPRFVTRKITKFFNQNG
>NZ_CP011934.1|WP_000412863.1|1649439_1651557_+|flagellar-biosynthesis-protein-FlhA
MEKKWWNQSDVILGIGAVAVVAMLVIPLPGFILDILIIVSLAIGLLVLLTSLSVNEPADFSIFPSLLLITTLYRLALNVSTTRQILSKGPAMNSHVIDAFGSFIIGSESGLSKYVVGFIIFIILVLVQILVITKGATRISEVAARFTLDALPGKQMAIDMELSSGNINEEEAKKRRKRIEAEVDFYGSMDGASKFVQGDVRAGLIITAINLLGGVIIGSSIRGESFTQAIETYGKFTIGDGLVSQIPALLTTVATGIIVTRSGSESDLATQFKSQLFSNSKVLYVVAGSLGFAAFIPGLPFIPLVLLSAGIAYLGYSLEQTVKEQLESIEKKEKESGQDRKPKDFYEELRTDPIEIEVGYHLIPLVDVSQGGALLDQISNLRKKFAQDNGVVIPPVRILDNLDLNPDTYSIKINGTEVGASTVKPDKLMALNTSPGSAESIAGEDFLEPSFGQRAKWISAEDKSDAEAKGYTVVDASTVVVTHLKELLATHASTLLGREEVKKLLDHYKTSYPTLIGELDADKPGNLGIIQQVLQNLLREGLGIRNLVPILESIANNLSKYQNPYILTELVRQSISRTVVRDYLSMDGKLRVITLESRILDRLNKSITQDRIENRDVLSLAPDFYRRLIDSVAELYRNFRTEGKFPIFVVNREVRLPFSYMLAKEFPPRNFGVLAYEEIHSSVDSVIEAELKLPQAQTAGISEET
>NZ_CP011934.1|WP_000393533.1|1651609_1652890_+|flagellar-biosynthesis-protein-FlhF
MEFAKIRGKSYQDCLMEMKMKYGSEATVISQTVVTEGGVMGTGLLAKKMIEIQIGIPEKQASREKIERKLQDLKDLLKQKSYASPERKKTLQTLKPLSKTLEEKEIAVEEEIEEITTEPDRVGLSFEKELLDKNSFLRRETSTVRKDSPLIRLGEKLVREGMSQSYVEEIISKVEERLSPLDQGRNHAVLERTIEILKERVSVDSDLFRGTGKNQRKVIFFVGPTGSGKTTSVAKLAAKYFLHRGKSVSLYTTDNYRIAAIEQLKRYADTMGMPFYPVKDIKKFKETLARDGSELILIDTAGYSHRNLEQLERMNSLLSCFGEKDSVENLLVLSSTSSYHHTSTVLKAYESLNYRRILLTKLDEADFLGGFLELADTYSKSFTYYSVGQEVPFDILSAEKNLMAECVVTPEKIAELRGEVFTVAGD
>NZ_CP011934.1|WP_000371638.1|1652917_1653832_+|MinD/ParA-family-protein
MDQAAHLRKLTEGNTSLKVLSSRKPTTKIVAIASGKGGVGKSTISVNLAISMARAGQKVLVFDGDLGLANVNVILGIIPKYNLYHVVKGHKSLKDIVIQTPEGVDIIAGASGYSQLANLNDTQRNSLIKGFSELDNYDIMIIDTGAGISSNVIGLTLPADDVIVITTPEPTAITDSYGLIKAIVSQSRDKNLKMVVNRVRSAIEGKKVADRVIDISGQFLEVKVENLGFIFQDEEVEKSIREQKPYIINSPKSKAAACLNRITYSLLNQDIEPLEDSGIGGFFKKFFNFMDVRDKEFDKNDEEE
>NZ_CP011934.1|WP_001053203.1|1653835_1654312_+|hypothetical-protein
MNLQILFIGVFVIVAFVISALCGFLIGNSFGHILLVTFLSMIAFAVLGFGIHAVLETKVPEFLDFLSNIGGEYIPPTQATDSENVVRGRDYTSNASDTDLSEGSSSNSEVFASSSPKRQKDGNFGDHIMVENIAIKNEPKLMAEAIRTMLARDDMGEK
>NZ_CP011934.1|WP_000039671.1|1654439_1655240_+|RNA-polymerase-sigma-factor-WhiG
MSKKYEKYNQQDETELWKSYRETKDQDIRSYLVEKYSPLVKHVAGRIAIGMPQNVEFDDLVSYGVFGLLDAIEKFDPERLIKFKTYAMTRIRGSIFDELRSIDWIPRSIRQKAKQLEQIIGMLENKEGQQVDDDAIAKELGISMEEYNSLLTKISGTSLVSLNDIWFLGDENDEVSFMETLESPMNMNPDTIIEKEEIKNVIVEAIKTLPEKEKKVIVLYYYEDLTLKEIGEVLEVTESRISQLHTRAVSRLRSKLGKVKSVISRK
>NZ_CP011934.1|WP_000535110.1|1655265_1657251_+|FapA-family-protein
MGSLIPFLQDQSKELDRIQNEQVEVYGDTLENSLRLAAKHLKKQVHELDYVVLKRGKKKLFGHEPWHIRVSILPEDNFLDELTELDQKLTGGSGKLVSKDLKDLIQPKDKNGKALVQILRNGVYLTTFAPLGDGHPVDLDEVFKKLSLKGVSGEDGKLVRKIVKEAKGEPILISQQKPRPGMEAKLILDISPDKMKAKVTILPPRPGGRDFEVRDVVNHLKNAGVKYGFKEEEIQRKLEEEFYNQPFIGAEGDYPINGKNAQIIYHVRTSKNISFREDESGRVDFKDLDLIENVVVGQLLAEKIPAEKGKYGRTLFNELLPAKDGADTDLKQGKGTILSEDRSKLTAEVNGQVVYATGRLSVETVYRVNGDVGIKTGNVTFLGSIVITGNVEDNYSVKAAGNIEIYGTVQKARVEADGDIIIRQGISGREEAHVESTGGNVIAKFIQSATVITEKDVMVQEGVLHSFVSAGGKILCNGKRGQIVGGTVRASELIAARSIGSSANPATELVVGIDPKVLKQIADYEAKMHESQAKHEQVFKSLKTLQARKESDPASFTEEHENQLSKMQKAVDKLDSRIKEFETEINNLKNYMEEKSSHGKISIEKVLYGGVTMRIRNSDFKTRNEIKNKTFVEENGMIRQVPYEDPEPDKKDWRKKRNRGN
>NZ_CP011934.1|WP_001239630.1|1657259_1657613_+|hypothetical-protein
MRLSDTFLGYGQAPDMIRKQQVENPFTMPHMISETSRVVKEYNDTRKYAVELYTDVFSLSPESRERMALARNQKIDQIKDRLKTYKSASDDKSYTYSSNGQKTSNVPSNRGKIEFFA
>NZ_CP011934.1|WP_000418458.1|1657658_1658711_+|hypothetical-protein
MELFAVFAINAVVSVVLYYTITSKVTERIRTHMLGKINEEIRDFIDELETESLRQVDLMGARILTFKEITSKAEELVKRIEQSTSPDILEKIQIVDKDSVINNENKRSENLYPLKNGNHTGVSDSVQQGVGHIYKENLDLTREDAENFSNLQKVSNSKIHTSYIQKLETTSKVVKKEVVSQNKPKILPQGSTSNLVLETIGKGIRKFFGIQEIKTIRSENETSGNDFFPGTRNSTLDISLDENPFAPISESKLNETSSLVFKDNLKPKEADFGRILQENIVGYQPIKPDSTKISAEAALLEIGDDSTKIEKVVFLLKRKYTHEEISEVLDLALGEVDIIERFRLDRNRRF
>NZ_CP011934.1|WP_000077420.1|1658710_1658992_+|DUF370-domain-containing-protein
MSQFSVLNVGFGNIVLVSKIVSIIHSDSASAKRIRNEAKSNNSLIDATQGKKTRSIIVTDSNHLILSNLRVESLTKRIESRDNSIASEEEDLD
>NZ_CP011934.1|WP_082280300.1|1658988_1659570_+|guanylate-kinase
MNSAKLFVLSSVAGGGKSTLIQKIREKHPEILFSVSCTTRAPRPGDKEGITYFFLTKEEFEKGISESAFLEWALVHDQYYGTPLKFIEGAFQKGSSVIMDIDVQGAKIIKEKLPDKIVTIFILPPNEKEWEKRLRGRGTDSEENILKRIQNGKLELERQNEFDYKIVNDNLDRALAELENIILKSESKSTTEK

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Crispr_ID: NZ_CP011934_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011934_7

3029067-3029169

Orphan

Consensus_repeat	Method
TTTTTTAATTTCATATCAAAATCTTGATCGTTTTAAGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011934_7

>merge|NZ_CP011934|7|3029067-3029169|CRISPRCasFinder
TTTTTTAATTTCATATCAAAATCTTGATCGTTTTAAGAGACGTAATTCTGTGGGAACTACTGCATTTTTTAATTTCATATCAAAATCTTGATCGTTCTAAGAG

>NZ_CP011934|7|7|3029067-3029169|CRISPRCasFinder
TTTTTTAATTTCATATCAAAATCTTGATCGTTTTAAGAG	ACGTAATTCTGTGGGAACTACTGCA
TTTTTTAATTTCATATCAAAATCTTGATCGTTCTAAGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011934.1\|WP_000412150.1\|3023820_3025134_-\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl\|CDD\|223694
NZ_CP011934.1\|WP_000459254.1\|3018085_3019024_-\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
NZ_CP011934.1\|WP_000833704.1\|3019028_3020957_-\|protein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
NZ_CP011934.1\|WP_000499622.1\|3038496_3040227_+\|apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|234721
NZ_CP011934.1\|WP_000854854.1\|3037455_3038490_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377013
NZ_CP011934.1\|WP_000196652.1\|3026279_3027053_-\|outer-membrane-lipoprotein-carrier-protein-LolA	unknown	unknown	gnl\|CDD\|319983
NZ_CP011934.1\|WP_100220168.1\|3033418_3034105_+\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|132880
NZ_CP011934.1\|WP_001045092.1\|3023077_3023824_-\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|273139
NZ_CP011934.1\|WP_001001362.1\|3029789_3030221_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379324
NZ_CP011934.1\|WP_000876121.1\|3030320_3030563_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000141830.1\|3021710_3022037_-\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|376903
NZ_CP011934.1\|WP_001072287.1\|3025142_3026258_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379173
NZ_CP011934.1\|WP_000508810.1\|3027511_3028681_-\|DUF1577-domain-containing-protein	unknown	unknown	gnl\|CDD\|369443
NZ_CP011934.1\|WP_000079211.1\|3034116_3035019_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275263
NZ_CP011934.1\|WP_000365025.1\|3031577_3033278_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173838
NZ_CP011934.1\|WP_000493051.1\|3030741_3031407_+\|protein-L-isoaspartate-O-methyltransferase	unknown	unknown	gnl\|CDD\|178974
NZ_CP011934.1\|WP_000944038.1\|3040226_3040997_+\|exonuclease	unknown	unknown	gnl\|CDD\|379215
NZ_CP011934.1\|WP_000433684.1\|3022092_3023103_-\|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234682
NZ_CP011934.1\|WP_000768572.1\|3036349_3037369_-\|4-phosphoerythronate-dehydrogenase	unknown	unknown	gnl\|CDD\|240635
NZ_CP011934.1\|WP_000723991.1\|3020967_3021714_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275213

Protein	Function_ID	Function_description	E-value
NZ_CP011934.1\|WP_000412150.1\|3023820_3025134_-\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	gnl\|CDD\|223694	COG0621, MiaB, 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis].	2.45568e-119
NZ_CP011934.1\|WP_000459254.1\|3018085_3019024_-\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	3.22421e-88
NZ_CP011934.1\|WP_000833704.1\|3019028_3020957_-\|protein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	2.82717e-150
NZ_CP011934.1\|WP_000499622.1\|3038496_3040227_+\|apolipoprotein-N-acyltransferase	gnl\|CDD\|234721	PRK00302, lnt, apolipoprotein N-acyltransferase; Reviewed.	3.2833e-62
NZ_CP011934.1\|WP_000854854.1\|3037455_3038490_+\|hypothetical-protein	gnl\|CDD\|377013	pfam03280, Lipase_chap, Proteobacterial lipase chaperone protein.	8.38397e-08
NZ_CP011934.1\|WP_000196652.1\|3026279_3027053_-\|outer-membrane-lipoprotein-carrier-protein-LolA	gnl\|CDD\|319983	cd16325, LolA, LolA, a periplasmic chaperone. This family contains periplasmic molecular chaperone LolA which binds to outer-membrane specific lipoproteins and transports them from inner membrane to outer membrane (OM) through LolB, a lipoprotein anchored to outer membranes. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts OM-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. Studies have shown that hydrophobic surface patches large enough to accommodate acyl chains of the OM lipoproteins and the structural flexibility of LolA are important factors for its role as a periplasmic chaperone.	2.11314e-24
NZ_CP011934.1\|WP_100220168.1\|3033418_3034105_+\|DNA-alkylation-repair-protein	gnl\|CDD\|132880	cd06561, AlkD_like, A new structural DNA glycosylase. This domain represents a new and uncharacterized structural superfamily of DNA glycosylases that form an alpha-alpha superhelix fold that are not belong to the identified five structural DNA glycosylase superfamilies (UDG, AAG/MNPG, MutM/Fpg and helix-hairpin-helix). DNA glycosylases removing alkylated base residues have been identified in all organisms investigated and may be universally present in nature. DNA glycosylases catalyze the first step in Base Excision Repair (BER) pathway by cleaving damaged DNA bases within double strand DNA to produce an abasic site. The resulting abasic site is further processed by AP endonuclease, phosphodiesterase, DNA polymerases, and DNA ligase functions to restore the DNA to an undamaged state. All glycosylase examined to date utilize a similar strategy for binding DNA and base flipping despite their structural diversity.	1.8299e-08
NZ_CP011934.1\|WP_001045092.1\|3023077_3023824_-\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl\|CDD\|273139	TIGR00560, pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis].	4.42468e-35
NZ_CP011934.1\|WP_001001362.1\|3029789_3030221_-\|ATP-binding-protein	gnl\|CDD\|379324	pfam13671, AAA_33, AAA domain. This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	1.65336e-13
NZ_CP011934.1\|WP_000141830.1\|3021710_3022037_-\|preprotein-translocase-subunit-YajC	gnl\|CDD\|376903	pfam02699, YajC, Preprotein translocase subunit. See.	1.26653e-26
NZ_CP011934.1\|WP_001072287.1\|3025142_3026258_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379173	pfam13413, HTH_25, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.16019e-20
NZ_CP011934.1\|WP_000508810.1\|3027511_3028681_-\|DUF1577-domain-containing-protein	gnl\|CDD\|369443	pfam07614, DUF1577, Protein of unknown function (DUF1577). A family of hypothetical proteins in Leptospira interrogans.	1.24948e-102
NZ_CP011934.1\|WP_000079211.1\|3034116_3035019_+\|radical-SAM-protein	gnl\|CDD\|275263	TIGR04470, hypothetical_protein_ALIPUT_00462, radical SAM mobile pair protein B. Members of this family are the downstream member (B) of a pair of tandem-encoded radical SAM enzymes. Most of these radical SAM gene pairs have an additional upstream regulatory gene in the MarR family. Examples of high sequence identity (over 96 percent) from cassettes in several Treponema species of the oral cavity to those in multiple Firmicutes in the gut microbiome suggest recent lateral gene transfer, as might be expected for antibiotic resistance genes. The function is unknown.	2.0023e-20
NZ_CP011934.1\|WP_000365025.1\|3031577_3033278_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	6.43211e-42
NZ_CP011934.1\|WP_000493051.1\|3030741_3031407_+\|protein-L-isoaspartate-O-methyltransferase	gnl\|CDD\|178974	PRK00312, pcm, protein-L-isoaspartate(D-aspartate) O-methyltransferase.	1.02645e-55
NZ_CP011934.1\|WP_000944038.1\|3040226_3040997_+\|exonuclease	gnl\|CDD\|379215	pfam13482, RNase_H_2, RNase_H superfamily.	5.30157e-30
NZ_CP011934.1\|WP_000433684.1\|3022092_3023103_-\|anthranilate-phosphoribosyltransferase	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	7.32299e-153
NZ_CP011934.1\|WP_000768572.1\|3036349_3037369_-\|4-phosphoerythronate-dehydrogenase	gnl\|CDD\|240635	cd12158, ErythrP_dh, D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains. D-Erythronate-4-phosphate Dehydrogenase (E. coli gene PdxB), a D-specific 2-hydroxyacid dehydrogenase family member, catalyzes the NAD-dependent oxidation of erythronate-4-phosphate, which is followed by transamination to form 4-hydroxy-L-threonine-4-phosphate within the de novo biosynthesis pathway of vitamin B6. D-Erythronate-4-phosphate dehydrogenase has the common architecture shared with D-isomer specific 2-hydroxyacid dehydrogenases but contains an additional C-terminal dimerization domain in addition to an NAD-binding domain and the "lid" domain. The lid domain corresponds to the catalytic domain of phosphoglycerate dehydrogenase and other proteins of the D-isomer specific 2-hydroxyacid dehydrogenase family, which include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence.	3.37285e-105
NZ_CP011934.1\|WP_000723991.1\|3020967_3021714_-\|hypothetical-protein	gnl\|CDD\|275213	TIGR04420, Sec_Non_Glob, Sec region non-globular protein. Members of this family occur only in the genus Leptospira, always encoded between genes for the YajC and SecD components of the Sec preprotein translocase. Sequences have an N-terminal signal peptide and a C-terminal transmembrane segment. Between these are regions of non-globular, low-complexity sequence including Lys-rich and Ser/Thr/Asn/Glu-rich regions.	2.06505e-86

>NZ_CP011934.1|WP_000508810.1|3027511_3028681_-|DUF1577-domain-containing-protein
MGGIKLKERDLDVINSPEQRKHIIEKHLLNQSLRIKGDLNRETITIQRYVDSGEKIIAGISDETHFSENDEIVLYKILAKYVQLECSFIRKTRPGVAEFSVNKVSIAKSNRAFPRYSVAEDAAHVTNINSSKTVIDASLFNIPTLVKVSFEDYKTKLKPDQLGLVEIDVFRSDQDEKFELIKRTKKYIHIENTSLEESYKSKSENQVDVEDEIHEEIPSLMRKYKDEKIVSEIIYPIIYINHSRQSIPLGYIWVRNKEKTLGNNTIEKLAELSKEMVARIKESNTVLTTEKFPIIDISNNGICIKITEPHLIQTLPKHTGFVFDIYIRMQGYFKVFGAIRWLSYDEVGSLILGMELVAKSSFPGEREKFHRNVELLGQGKFTGLKTHAI
>NZ_CP011934.1|WP_000196652.1|3026279_3027053_-|outer-membrane-lipoprotein-carrier-protein-LolA
MTRFPRHLILVKKIPGDPVFLMKKTIILSFFILFLALEPSLLAQPAHNWNSPSEVVKQVKKKFSDLNSYKADFQIQTVSNKKSKNMKGVCLYKKGGRIRYQFNEPSGDEIVSDGKTLYIYIARLNAVGKQDLTLNKSNKSGPIFSNFTDEGLSRIFRKYHYKFDSIEQPQTSSKDGRKYFVLNLEQREKIGGFETMLLYVDAQTYFIQKAVASDGRGKETTIEFSNLEINPDLEDGQFNFHISGNAKIINNPLVSEQ
>NZ_CP011934.1|WP_001072287.1|3025142_3026258_-|helix-turn-helix-domain-containing-protein
MNQKRVGQILREAREEKKLSVKDVARETNISVKYILALETEDYSQFPGETFTMGFLKNYGGYLKLDTGQLINLYRGEKIEESQAPLEELTRPTASYYTKINVDKNKIFTIASVLIILISAYLIIDSFIGPSSDEDSVEESGKKLDIPENIDFLSRSIPENRSESFILTPDKGVSFSVSNQQCKLFIDSVEKGGAVNTAVLAFNVYPELTVYKFRLSEGQEKILSYTIPEISSLRRNVRIISQAVTENSAKVLVTLSDEEQKQENNNSVDNTKTLGDVPIQVTLFFNKPSYAEFIIDGQMGFRGLVQTGETRSLEAKDRLELKVGDGSAVEMIQNGKPKITLGRPGKLVKKIFVKTQNPYDSTQSIIKELGE
>NZ_CP011934.1|WP_000412150.1|3023820_3025134_-|30S-ribosomal-protein-S12-methylthiotransferase-RimO
MEKKFYITTLGCPKNIADSMSMHHSLLEEGFTPASLPEESDFHFINTCTFIQSATEETIQTILSAAQVKKQNHQKLVVVGCFAERYPDNIHSEIPEVDLFFGTGKYSQAGKILREKFPELSPSQLEFNDSLLERWKLSSKIENYSKPYAYVKVSDGCNRGCSFCIIPSFRGKFVESPLDDILRDTNRAIRAGAKEICLVSQDTVYYGRDSEILLDMVRKVAEIDSLEILRLLYLYPDKKTEKLIRLMGETSKIAPYLESPLQHVSSKILKVMNRTGESSYFKDLFSLAREVKPGLEIRTSFIIGYPGEEPEDVDQILRFIEDTRPEKVNLFSYSPQEGTKGAQLKQTVSEKEKSKRINLIRDSHLEILEEIHESRIGRTYDAIVDGIEDGQVVVRRFQDAPEMDEVVYVDDVSLIPGRIGKVRIDSFYEYDMNGTWV
>NZ_CP011934.1|WP_001045092.1|3023077_3023824_-|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MNKVIFNIPNILTMLRVAAVPFFVWFLFQKELEYHIAALVLFSVASLTDLIDGYLARKWNQETEFGKFLDPLADKIIVTGCFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQGQSIRTTMLGKVKTVFQMGAIVLILVFFILISSKKRILINQAYATGKANGLTVFEFATNNAIQFFRNLDQNNGLGDVVFGLGTFVPYWGMLVTTAITVISGIRYLVSNSKVLYPSNLKGMFQKNGTKSSRS
>NZ_CP011934.1|WP_000433684.1|3022092_3023103_-|anthranilate-phosphoribosyltransferase
MEPRAAVLKLVEHKHLTALEAESFMNHVMKGEVSEILLSSFLTAMRSNGESVEEVLGCTLALRKNALRPKTVFPFDLLDTCGTGGDGQGTINISTLSAIVLASLGIKVAKHGNRSVSSHTGSSDILTRLGYQTETTQEEVEAHLVNRGFTFLFAPMWHPSMKHAGPVRKELGFRTVFNMIGPLSNPFSPQFQIIGVYQPELMELFIKVLQSLGLKRALVCHSRDGLDEFSIFQITDYTFLENGIISRHSFDPKILGLSSLNKEEVYASSSDHAEVLARKVLNSESIAGTHAVALNAGAGLFVMGKIDTIEQGYQIAKEAILSGKTKKYFEDLISKE
>NZ_CP011934.1|WP_000141830.1|3021710_3022037_-|preprotein-translocase-subunit-YajC
MTFDILLQLAQAAGEGDKSPFSTLLLIPIMLVIMYFLVIRPQRNEEKKRKEMIDSLKKGDEVVTSSGIHGKVVEIKDNNEVVVLNIAKDTNVSFTASTVLKKKQQADK
>NZ_CP011934.1|WP_000723991.1|3020967_3021714_-|hypothetical-protein
MKKISILILIFLFLGNLALFSQDGEEIDFLEKVTEPKKTVSKKSSNKAGASPGTSTPKKKEKKRSKKKRSKKSSSSIPNNLEETQKKNVIPNSNETSSGNNNSNLNGANSGSSNTLESGNVDEQRVSASKMDLRDLPKPYWVNEEVQIHPNNLPGYTVSQKLEQGPSFGSGLSEILKLGEDKKKEENKKKVQEVQKSGSFTGFLSEYKKPIIIIVFILLFALYRLKAGKSRGSSSRKSPVTINKMRRD
>NZ_CP011934.1|WP_000833704.1|3019028_3020957_-|protein-translocase-subunit-SecD
MKSATWIFLPLLIILAATVILYPNFATRELELAVRKEFISISPEQKKAILSRFEERWNREYKQSDWIISPSPTEFKDESFLLVKGRFITSAKINQISQENPELILEAKNKLRPTLVEEWITKGRPLTIKLGLDLQGGMRVAMKGDFEDYASKLRESYIKEIENLNKTVTDPSADEKEKKKAKDRLSEIESYFELSPSRKLLELEKAKLIIDNRLTSQNLTEPQVRIQKDQDSIEVSLPGVTNSSQILEIIQNTETVEYRLEEPENSAGNGLTYASIIQQEENRLLELKRREETDIVQYQNIIKQKLGKAEQDKFLQGLEEKYKIPRDKYRVFAYWARGNHQNSTLLPRKFVVLEKAIALDGRDMRDARPSFENNSFGYIVSFTLTSSGAEKFFEITSQNKGRNLAIVWGDKVVSAPTIRSAIAGGVAQIDGSFTKEEAVDLANVISEGALPIPLRVLEMRFIGPTLGIESIEVGMKAVLIGFVLVMFYMILIYRLSGLVANAALFANIVILSALLSLMGFTLTLPGFAGIILTVGMAVDANVIIYERIKEELRAGKSATVAVAQGFDNAFWTIIDSNVTTLISGILMIRLGNGPIKGFAITLCWGIITSLFTSLFLSRLVMDLLVNRLGVQKLQLGFKKLES
>NZ_CP011934.1|WP_000459254.1|3018085_3019024_-|protein-translocase-subunit-SecF
MFDFIKYKYVSICISLTLIVFGFSYTYAVHGGFANSLDFNGGLRTVVEFDQNMDRKKLENYFAENKIEAVLLLLDKEKHHYQIDIGLGSVDSILLKYREKNGLKPTDKVELSGIDALISILIADFRIDKSNILSANQVGAIVGGELSSTGTTLLGLTMAIILAYISFRFQFKFALGAILALTHDLILTVAFIGFFQIKPSVPIIAALLTLLGYSINDTIVVFDRIRENSAGNLNQTFGQTINSAINQTLGRTFNTSFATLISIVAIIIGGATELFDFAYVLTFGIVIGTYSSIFIAAPLVDIYDQVIRKARD
>NZ_CP011934.1|WP_001001362.1|3029789_3030221_-|ATP-binding-protein
MNEEKSLILLRGLPGAGKSRLAKLLSENGKYPVFSVDDYFTDSKTQEYNFDYKKNHLAYKHCEDCVRKEAERGTSKIFSDNTFTLSWEMEPYFQIASEFEYTIFVITVENYHNGKNVHSIDDESLKKMASKYKVRLLPEILSE
>NZ_CP011934.1|WP_000876121.1|3030320_3030563_+|hypothetical-protein
MKYLETEQIIPSKGMSYTMYEVEGEDQIQKMMTYIPNTDEIHIYPKPPVKKLYKPELCKVIDEVVFSELWKLGEERKAAK
>NZ_CP011934.1|WP_000493051.1|3030741_3031407_+|protein-L-isoaspartate-O-methyltransferase
MFSSSKVCNPILREQERKNMVDLQIASRGIRDKKILSAMLSIPRECFVPNSHISQAYEDKPLPIGCNQTISQPFMVAWMSLLLEVRKGDRIFEIGTGSGYQSAVLIFLEATLYSVEFFDSLSKTATQNLECWNPGCTQTNRFMIGSATEILKPELQFDKMISCAALPNLPDTKSSYFQSLIPGGIFIFPMGKRDQSLIFAKRNLNDWSFESKGGVRFVPLL
>NZ_CP011934.1|WP_000365025.1|3031577_3033278_+|acyl-CoA-dehydrogenase
MDLLNPKKTEFKHLDEKSRNIMKRTIAFFEKKGKNKLKEDDRNQTWYADFLEFQKSEKIFATLMTPSGYGENDSRWDTTRICDFNEIAGFYGLCYWYTWQVSMLGLGPIWNSKNEEIKHKTAKLLLDGEIFAFGLSEKEHGADLISSDMSLENKGNGNYIANGRKYYIGNSNKAAIVSTFGKMKDTGNYVFFAVNSGHKNYELIQNVVNSQSYVGEYALKDYPISEKEILSKDREAWDASLSTIAVCKYNLGWASIGICTHSFYEALNHASKRKLFNRNVTDFSQIKQMFVDAYCRLFSMKLFAARAKDYMRSASATDRRYLLFNPMVKMKVTMQGEEVINLLWDVIAAKGFEKNMYFEMAAKDIRGLPKLEGTAHVNMALIIKFMNNYFFEPNSSLPVVPKIDDFKNDDFLFNQGTTSKGFEKITFRDYNEVYSNIDLPNVQIFRKQIAVLKEFLKSTPPDSKQSKDLDFMLILGELFTLVAYGQLLIENAAIEKVDNDLLDQIFDFMVRDCSKYALQLYSKRSSTKEQMEKCLAMIFKPAENEELFNRVCVKVYSYKDAYEMAP
>NZ_CP011934.1|WP_100220168.1|3033418_3034105_+|DNA-alkylation-repair-protein
MDSIRSKKEIKLILSKLSDSDESLWIFIIESELLKKKIKFPLLEFVGKELYFKIPEMNQIYFTDQIIKLGHMGSYVISAIILQLRMEKHFEQSLNKAVEYILLGNEWYVCDIIGERIMGYFLLKEPGKTLPILKNYINDKNGWIVRSVGVASHYAVKKGLGKKYVEVTFYLLLSKTNTKDFHTKKGIGWALKTISKFYPDIIQKFESNLLANPSIQPFFRKKNRNWPK
>NZ_CP011934.1|WP_000079211.1|3034116_3035019_+|radical-SAM-protein
MAQSIRIKNILNKTKRRDPWFLDDYTINPYSGCSFRCLYCYVKGSKYGLNVEDKLSIKENAVEILDKQLSNLAKKNRHGIIVLSSATDPYLQLEKERGLTRELLKIILKYKFPVHILTKSDLILRDLDLLSEIEKNAILPVDLQNQLSRKSFITFSFSILDDSIAKIFEPGATSPSLRISALKETLKEGFFSGVSLMPLLPHISDTGENLEFMFQTFQEIGIRYIFPASLTLFGGNDPLDHKNLIFKAIENHFPHLLSKYQNFFSKNFRMPNFYQNALYHKTSELCSKYGLQKGILTTEF
>NZ_CP011934.1|WP_000768572.1|3036349_3037369_-|4-phosphoerythronate-dehydrogenase
MKLKKPILYYPEGTIGAKEIFSSFEKLEVRSYPNDRIREISRDEPTILIANTRFQVNRDNIQNFPTVKIFATVSSGTDHVDFNALKEFRKIFLNAPGCNAGSVAEYCFAGLLNRFKESELKGLKIGLVGHGHTGKEFYKILISKGVNCIFYDPFYKTESRPLSEVLDASVLSFHVPLTKDGPEPTFRFVSTSLIDSLKSGTVFINTSRGEILSREAFNRLIARNDIFKILDVFDPEPPTLEMGRELSEVKHSILTPHVAGYSQLGRIGGTYRVAEKLSILYQDKPLPPLNFFLQTFGEFKTSTFLKEEDRLLREAWRNGDTNYFEKRRNTYPIRLDWDF
>NZ_CP011934.1|WP_000854854.1|3037455_3038490_+|hypothetical-protein
MKTLQQKITFPILVGLISVTLIMLIWFVFFSGSKITTSSSASLDPESSSGSEGWILNQAIINTSRKIFDENGNWLSFDELIQYASNGEINLISELSDLRRQCPENIHYEQCNEIIRAFIADHYFGKDAEYLMKLFSSYLRYETKMKELEISDKLNRAEKYELIKKQRREFFSDKDTKLIFGLEEAEETYLDSLGGFLKDTETLSGEQRMQKYEEFRKNVYGQYYNTIKKREPKYNTYETEMFLREKELERMSSSERNSKTRHIREKYFGKDGADRMETVYQESEEKEKKEKQTAQEESDWIRKNPNVKVEIKEKALMEIRIKNLGKEEAEEYSRRLKYEEEIKK
>NZ_CP011934.1|WP_000499622.1|3038496_3040227_+|apolipoprotein-N-acyltransferase
MFYNFISKDSILYRLILCFGIGIGTVFGLSPFSFFSAGVFASISCIFLFFSLNRTSIWKAFLWFLILSQILNFTAFYWIPGAISRISGANTFVSILFFFLYGLISHLKFFLFYTLFRFSKIDSASKTYILLIFPAAGTLSDMITFQIFPWYWGNLISGSIVFEQFASICGVYGLSFLLLFISSTFLILVNYYKYKNSKEFKTSIASLICIAFIYGFGLYRIGYINQSQNELKPKNLSVLMIQPDTSPGTKNLKADASYLSATMSKVFSLAIPTFENSPSLIVIPESAIPFHGTIDSEENRKEKIYSSTMEGIILYLSKHTGADVLFNELNLDENKLRNQVSLFKNLDGKTERYNKRRLLPFGEYLPMEKNFPFLRSIFQETSRYVPGGFPKLLIGNKIQNQRSFLPPEISKLNEPKTYRYEFSSIVEHTNKIRNLEYSYSILPLLCYEAMFTELVLDYFQNEQKPEVLINITNDSWFDSELEAYQHSGAVRLRAIETGLPLIRSAVSGISEVWDARGIPMIVPIGFHETGTRTFSIRLDAIESTIYTRFGNSFLWIFCILILISRLIFVSRIERKS
>NZ_CP011934.1|WP_000944038.1|3040226_3040997_+|exonuclease
MLRHTFCHLPGIDSKEEKNLWEKGIYDWKDLEIYLKTEPAPIRNLILDALEFSKKELERENFFYFFHVFSPKHHWRLFPTIRKKLLYMDIETTGLGNDDRTTVIGTFDGYEYRSYIRGFNLDFFLENLSQDQIFVSYNGIAFDVPFLEREFNVRFRNNHIDIMFFLRSLGIRGGLKGCEKTLGVHRPETAAITGIEAVNLWKQYVDYDDMDALKILEEYNREDTVNLEILFIKGYNLKIKETPFYGEVIQEPLQLR

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Crispr_ID: NZ_CP011934_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011934_8

3812038-3812127

Orphan

Consensus_repeat	Method
AAAAAAGTACTTGGATAATCCACCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011934_8

>merge|NZ_CP011934|8|3812038-3812127|CRISPRCasFinder
AAAAAAGTACTTGGATAATCCACCTGCGAAACGATCCGTAGGAAGTTGAGCATGAGTTTTTATTGAAAAAAGTACTTGGATAATCAACCT

>NZ_CP011934|8|8|3812038-3812127|CRISPRCasFinder
AAAAAAGTACTTGGATAATCCACCT	GCGAAACGATCCGTAGGAAGTTGAGCATGAGTTTTTATTG
AAAAAAGTACTTGGATAATCAACCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011934.1\|WP_001025586.1\|3805472_3806018_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|310150
NZ_CP011934.1\|WP_000752031.1\|3804852_3805395_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_001973364.1\|3816139_3816337_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000016926.1\|3812745_3814566_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_001046568.1\|3800290_3801532_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000410901.1\|3816392_3818624_+\|ComEC/Rec2-family-competence-protein	unknown	unknown	gnl\|CDD\|377126
NZ_CP011934.1\|WP_001221822.1\|3814562_3815531_+\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|234866
NZ_CP011934.1\|WP_001058915.1\|3821083_3821908_-\|ABC-transporter-permease-subunit	unknown	unknown	unknown
NZ_CP011934.1\|WP_000875567.1\|3806782_3807331_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000087784.1\|3807883_3808579_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_CP011934.1\|WP_001288326.1\|3821900_3822815_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP011934.1\|WP_000620232.1\|3798545_3800096_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271325
NZ_CP011934.1\|WP_000692397.1\|3810322_3811084_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|238847
NZ_CP011934.1\|WP_000691324.1\|3823022_3823505_+\|phosphohistidine-phosphatase-SixA	unknown	unknown	gnl\|CDD\|224973
NZ_CP011934.1\|WP_000620257.1\|3802239_3803682_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271325
NZ_CP011934.1\|WP_000701781.1\|3819488_3821000_-\|HDOD-domain-containing-protein	unknown	unknown	gnl\|CDD\|370050
NZ_CP011934.1\|WP_001202094.1\|3808575_3809760_-\|isovaleryl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|185640
NZ_CP011934.1\|WP_002156370.1\|3809838_3810240_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011934.1\|WP_000098508.1\|3818586_3819492_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|273252
NZ_CP011934.1\|WP_000874918.1\|3812146_3812740_+\|outer-membrane-lipoprotein-carrier-protein-LolA	unknown	unknown	gnl\|CDD\|225390

Protein	Function_ID	Function_description	E-value
NZ_CP011934.1\|WP_001025586.1\|3805472_3806018_+\|hypothetical-protein	gnl\|CDD\|310150	pfam05345, He_PIG, Putative Ig domain. This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.	0.00018825
NZ_CP011934.1\|WP_000410901.1\|3816392_3818624_+\|ComEC/Rec2-family-competence-protein	gnl\|CDD\|377126	pfam03772, Competence, Competence protein. Members of this family are integral membrane proteins with 6 predicted transmembrane helices. Some members of this family have been shown to be essential for bacterial competence in uptake of extracellular DNA. These proteins may transport DNA across the cell membrane. These proteins contain a highly conserved motif in the amino terminal transmembrane region that has two histidines that may form a metal binding site.	1.96375e-54
NZ_CP011934.1\|WP_000087784.1\|3807883_3808579_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	3.16474e-66
NZ_CP011934.1\|WP_001288326.1\|3821900_3822815_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.99817e-79
NZ_CP011934.1\|WP_000620232.1\|3798545_3800096_+\|hypothetical-protein	gnl\|CDD\|271325	cd14955, NHL_like_4, Uncharacterized NHL-repeat domain in bacterial and archaeal proteins. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.	8.79351e-11
NZ_CP011934.1\|WP_000692397.1\|3810322_3811084_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	3.87155e-90
NZ_CP011934.1\|WP_000691324.1\|3823022_3823505_+\|phosphohistidine-phosphatase-SixA	gnl\|CDD\|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	3.18103e-24
NZ_CP011934.1\|WP_000620257.1\|3802239_3803682_+\|hypothetical-protein	gnl\|CDD\|271325	cd14955, NHL_like_4, Uncharacterized NHL-repeat domain in bacterial and archaeal proteins. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.	5.03767e-12
NZ_CP011934.1\|WP_000701781.1\|3819488_3821000_-\|HDOD-domain-containing-protein	gnl\|CDD\|370050	pfam08668, HDOD, HDOD domain.	2.79342e-52
NZ_CP011934.1\|WP_001202094.1\|3808575_3809760_-\|isovaleryl-CoA-dehydrogenase	gnl\|CDD\|185640	PTZ00461, PTZ00461, isovaleryl-CoA dehydrogenase; Provisional.	3.62267e-170
NZ_CP011934.1\|WP_001221822.1\|3814562_3815531_+\|tryptophan--tRNA-ligase	gnl\|CDD\|234866	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed.	5.90025e-152
NZ_CP011934.1\|WP_000098508.1\|3818586_3819492_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|273252	TIGR00755, Ribosomal_RNA_small_subunit_methyltransferase_A, ribosomal RNA small subunit methyltransferase A. In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification].	8.75996e-89
NZ_CP011934.1\|WP_000874918.1\|3812146_3812740_+\|outer-membrane-lipoprotein-carrier-protein-LolA	gnl\|CDD\|225390	COG2834, LolA, Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane].	9.0051e-12

>NZ_CP011934.1|WP_000692397.1|3810322_3811084_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MKIIVLVKQVPDTETSIKVGDKSINETGIKWIISPYDEFAIEEGIRLREKHGGEVIAVSLGPDRVVEALRTAYAMGADRAVHIKVDNYVPFDTNNTAELISNFAKAENADVIIGGRQSIDTDSSQVVIQVAELLGIPHIAFAINLEINGTAVKATKEVEGGTQTVETSTPVALTAQKGLNEPRYPSLKGIMTAKKKPVETKSAADLGSPASKIEIVGLEPPPPRIPGRKLEAADANAFASQLVKALREEAKVI
>NZ_CP011934.1|WP_002156370.1|3809838_3810240_+|hypothetical-protein
MIYALILTILCVLFFFLSYGFFQKSDTLLQKDSKIQETETKRTGSFQNESPRKNKSNLFKPSVFRSQFQSALHSPFQKESIFLLLSLCTWMLLPLFWGLAFFLKTDANVLIVIGFMIWTYYWLKYLLSTDETV
>NZ_CP011934.1|WP_001202094.1|3808575_3809760_-|isovaleryl-CoA-dehydrogenase
MRALLEKSNDLFNPTENHLALRENVAKFAKENMDTQAKEHDDYETFNLSLFRRIGSELGLFGVTVPEEDGGMGMDAVAAVIIHEELSAYDPGFTLSYLAHEVLFVNNFYHSSNAAQRAKYLLKVISGEWIGGMGMTEPGAGTDVLGMRTIAVKKGDKYVLNGSKQYITNGNVGSVFLVYAKMNKDSKRTTSFIVESSFPGFSVGKKEEKMGMRSSPTTQLIFEDCEVPTENLVGQEDGALVHMMRNLEIERVTLAAQSLGIAKRCIDVMADYTIRHREAFGKKLSEFGQIQRLLAESYADYQAARALVYQVASGIHPESRNSLGAASAKLVATQMAERVSRNAIQALGGYGYCREYPVERLHRDSILLSIGGGTNEAMQKNIVADLKKIYEGTP
>NZ_CP011934.1|WP_000087784.1|3807883_3808579_-|O-methyltransferase
MSRKNISLTESLEEYIFRNSVREPDSFLKLRKETGTLAQANMQISPEEGQFLNILTKISGAKRIIEIGTFTGYSSLCFASALPEDGKILCCDVSEEWTNVARKYWKENGLENKIFLKLGSALETLQVLIDSKSAPTWASDFAFGPSSIDLFFLDADKENYPNYYPLILKLLKPGGFLIADNVLWGGSVADLSHQEPSTVGIRKFNELVYNDSLVDISLVPIADGVSLVRKR
>NZ_CP011934.1|WP_000875567.1|3806782_3807331_+|hypothetical-protein
MKYKIILILSLMLFLFVSCPDEKKENELSTYILYSVLINATTQYDCVTSSEVVSDSYNKTTITFENKPQYYNSPSGNVVPKAIMPILIKKGQTIQVSSITTNVKYEATNQDLTFLFRKDGCHGTNSEIATYAGATNTNVFLGNTNTVSLTQFKFTADYNGIILIVGKNLGASLPGDIRVNVF
>NZ_CP011934.1|WP_001025586.1|3805472_3806018_+|hypothetical-protein
MNIQKNLYIFIFIIQTFNCSSSWLNIGCDLYCYAVVSELEAILEPPSITYNSYSPLIFTKNVNTSYTPEIKKITPTEGTLTIAPDLPTSLYLDNSTGIISGTPTQAQTKSTYRVQYENAGTILESNRFYILVQESSESGICNTTEIFPGCNSEQPYSCSDAVQPTYCYRELSHCQQDIYCY
>NZ_CP011934.1|WP_000752031.1|3804852_3805395_+|hypothetical-protein
MKKTLLIIFLIITILNCDPDKLNPYGIDGNEEENFRNIVLFLALRPSLTYEKTQLIFIKNINTSYTPILRNASIAGGSFMISPNISNTLSFNTSTGIIFGAPTLSQTKSVYIVDFINQETQVQSNPFNIFVEESEGSGACNTTGIFSGCDSKRPFSCSDAIRPAKCYFRASDCQNDVYCY
>NZ_CP011934.1|WP_000620257.1|3802239_3803682_+|hypothetical-protein
MIRLIILIFIIFLQACSPTSGKEIKNFLIPLVQGNGIGPIAIHENLDSLDPEEIPFRENLVNFEWALLYGDHLKLTKDSHLAVDDNGFIYIAADTDGNPFYDNSIHRLITGKKLVLGKYDSQKNEIWTHELENPYVNLDVTGIAVDTKGNAYVTGSSTIKNYFEKSRIEKKQFLFVIKVNSEGNLEWIREIGSTNSDYKINPGTIAVDTLGNSYVVGTSNGPFERDSIKPEGGFITKFDTNGNQIWAKELSALEAKITPTSVAFDKRSGNIYLCGSANNNNIRNDKNSGIGRNDLLVFKYDENGNGQIFARLGFALGSVFGNTITTDPLGNVLVGAYTDVDFASSTIQDNSHNGLIIKYDSSGAQKWIRQFGPSIPLKSTFISEITTDRVGNVFTTGSTNGFIKFNDGPSEGNRDVFVIKHSPSGEVLKLWQWGVQQKTMVGSGIGIDLNGNLYATGWTDGELFENRNIGKIDIFLIKFQ
>NZ_CP011934.1|WP_001046568.1|3800290_3801532_+|hypothetical-protein
MNLAIQLLKKNRILIFHITTSFIFLFSVYTYFYTIRKYSVNFPFGDDYNTILGFLDLWEKSNSKISILFSQYNEHRLVFLRIIILAYLKLFHIIDFSHLILIGNTFILLCLLLLYYTIEDKRKFILISPIFLAILNFSNWETQTWAMASLSNYPVIYFGFLSLYFLSKDKLINFVLGIFFAVIAVFCQGNGMFVFLSGVPLLLKDKPKLLIWLFIFLMIILLYFIIFPYDKPNGHPEFFSNTKFFFLSRIYYGLALLSNVFNSKFVLILGMIPLLGILYLYKNHFKISKLHLSMISFLLLSLSSLVITRGGFGFEQAFSSRYHINTLFLYSLIYICLFPLIRIKKHFLLILFFTLLFYYNTNFINIYQLSVQKNKIMNDKSCMSECTEYKTFPNVSRAKELLINFSAKGFFQN
>NZ_CP011934.1|WP_000620232.1|3798545_3800096_+|hypothetical-protein
MIRLIILIFIIFFQACSPTSGKEIKNFLIPLIQGNSSFPQNSFTSNPEERPIDLDQNPNILEENPMIIEENAVIPEERPLVFGRNPLNLEWATLLEIPSNNTIKTPNIAIDGNGFIYVASDSNANLIGDKLKIGTRDVILKKYDSHQNELWMKRIGSRNTHLTITGLAADINGNAYVTGYTNGPLEKALISDQDMFVIKFNTDGTIAWKKQAAPQRAKGVYNTYKVFTEGITVDIFGNSYIVGTSNGPFGDNADGNLGGGYIIKFDTNGNQIWVKQISIVGASIYPKNVAVDEDLRQIYVAGTSKNANFRTNKTFNYSNGAGGDDLFILRFDENGNQEFFTQTNLYRDSITPNSLTVDSFGNVLVGGSSIIDLEFGTYERTYLRGVLIKYDLNGDERWIRQLGPREDAQFIQRSTTITGIATDENGNIFTTGSTNGNIINEHSEPVGNQDIFLTKYNYLGQIEWIRQIGRLGETLYPGKIGIDFNRNLYTTGLTDDNGKEYQVIGGDLDLFLIKFR
>NZ_CP011934.1|WP_000874918.1|3812146_3812740_+|outer-membrane-lipoprotein-carrier-protein-LolA
MAFLKIRRILPGAAGLILVCGISVSGDPGRDRLGALLGRMSEISSLRASVTINNEISGTLSFKKPNYLHVKFSDGRVVSSNGRFLWFYSPARAIVGKQDLRGTSGGVFGLLSGYEEVTQVGGSIRLKSPTKTYEEIVVTMNSDNTPKSLRMKKRGSSEYTSISFSGVQTNVGLSASLFNFSAPSSAQIVENPLNEKE
>NZ_CP011934.1|WP_000016926.1|3812745_3814566_+|hypothetical-protein
MSGSSRTDAHKTFADLYRKQRSPEHQEKIDEVIQKSNDIFIRIDLMKKVDEEFEKKRQEENKKSEDEDKAKRTAEKSTTTSKSSAKPARKTETSSGGIGFLTNLFGGNTAINKFAKESGTMDVGFLGRKLQISSGVHNLFKFLKEDQIIATIQALRFCEQQGWRYWKPLVYNVVLNFNKLLNSIITLDSLFIDQISPEIFLNRATKLELYYARHLSRADCKDIIMTEVPELIRKDEKLVPKMPQITAGLSYGLNLEDGRPKMSDAIRAFHIVATKRMITWDEVVQQLNIPPINETKFQGSPDIIKEVETTLLRLADDIQTRLNRKEELQGLRERYFKIDDKGKMNFDFLNSIVDDYFENHVPENMQSASLKSSFKGTPHKLMYLLLRDFQASFAPILEGTVKVGTKNQSRDVIIMLPGLFKSDIEQINNLLRLLDAFNKKYPSFQYSFATYNEHTTSTVGVEDQITQNLLKLIGDAAGFMGKFAEKINILVENHLLAKQYEASGKLNERVLVSKEKVIEEIKILHRFIPYCDSPIVSGNRLNGKTLEFAFLEMAKLLYNYAVIYKDKLTITKLTLHKKIDTELASLTKEYERLAGKPYDTKRTEET
>NZ_CP011934.1|WP_001221822.1|3814562_3815531_+|tryptophan--tRNA-ligase
MRILTGVQPSGKLHLGNFFSVIRKLKEYQDSTDLFCFIADLHSLTTFSSKEKQTENTFNAVCDFLALGIDPDRCTFWLQSSVPEVTELAWYLSHFISVNQLSLAHSYKDKVAKGFHPGGGLFFYPVLMAADILGFDSDRVPVGKDQKQHLEFARDIASTFNREIGPVFKIPEPEIDETTALVPGVDGQKMSKSYGNTINFFDSEKELKKSIMSITTDSAGIDEPKDPSKSNIYAIHSLFLDAKGKENLKQKFLTPGIGYGDLKKQLLQDTLDYFAPYRKEREKIGADKIFAEESLKKGQTKARKIISNVLDRVRKELGIYQF
>NZ_CP011934.1|WP_001973364.1|3816139_3816337_+|hypothetical-protein
MVKLTVLNFLEISKNSGVPTFQSFIVKYKFMVVPTNSVALRIFKYLFFVITALTFSKFICNYPHF
>NZ_CP011934.1|WP_000410901.1|3816392_3818624_+|ComEC/Rec2-family-competence-protein
MEKHIRNWIPCSAFSKFSLGTLTGIVIDLIFPGTVLLWTGFAIGLFSISHFLKKRFQISKYFIFGIFFLLYVLTAFPEKFQINPQKKYFNVSQKNPFGKPEKIFQKKFREQVLLDLKEAGLEKNSNRIALGLIFGESKQLSQEFKTKAKEGGILHLFAASGLHLGVLMGAQFRLLSLIPSLGYNTPRIIPLLTGFLYLSALGYPTSLARAWIFAGMLLFQGLFFRKLRPVDLLLGSAWILWLLDPIRFYSVSFCLSFGAVTGIFFFSYPIRIACNFLSDENKISYFLKENLSISFSAGLGTMPVLLLAFESYSFGSILLNLIMVPLAGILLPILYLSLLIQKTKLILLTEPIWSITEFLIQILIYLSENLSKPLGFYKEMKGSVWIGITGWILLCIKILYYSYFIEKNYLKNTEQSIEKETLSSYEKFTENKTTSLQSESISIDIKESQQTYHKDQLSYNQIFNSKNIIFIKQNTQSDRSPKRRKANELLFPNYKKETPLLRDSNPEMFKTKASFQKQILPAFQKNKSFRKKTYPIFCILFFLTTLGIHILLYKSPDWFPSKNRIINNKFFFIFRNGDSLIFSGKCKYGFKRISNAFKISKKIYCDSTEKRPLTKVFVEDESCLSWTFQCLQDHPQTKIFYSGLNFEAWSQKSRFHFLKSKPIREISISHRSKILFFHTKKDSLFQLAQKTKIGSGWILLETPFGNQEDSKVWNRNRKLLGLTESWVFLEKDELQRIPISESF
>NZ_CP011934.1|WP_000098508.1|3818586_3819492_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MSSREYPFRKVSEIRKFLESKSSAPLKKWGQNFLIDPNAIRSILDCLNFDLLSTIDRILEIGPGLGAISHGLLDFKKPVTLFEIDPIYSNWLREYLPEFELKEGNALDFLSEYSQDSTYLFGNLPYYISSELTLNSVKNLKGLKGATFLVQKEFAKRISTEPSSIQFYLSAYGNWSLKKDIKAGAFYPKPNVDSSILEYKSLPVFKNESGFIALECICRTAFWGKRKKLTSSFRDAPIESLPLEVYSSENFSEKTFRTECLKALKSVNINLDKRPEELKSKDFHEAAKILSAYISEILNIS
>NZ_CP011934.1|WP_000701781.1|3819488_3821000_-|HDOD-domain-containing-protein
MKIQWFHYENEGYYLSVKNLNEPIESLNPLYLRITHFNQNIDKIIGFILDRYLQYLDIGPLRECIFSILRETLMNAIKANQKRMVFKEAGLDIKDPDQYLIGMERFKEELISKKDLYADLLEQNGLYVLITFGFNQNSFLLKVSNNVGILPEEDQRIQERISKARSYNDLSEVFENHGDESEGAGLGLAMSLLMLKNEGIEGDSYRIKSEEGITSAYIKIPFEFKKRNINLQKTGDIFAELDTLPTFPDNINQIMSLINKPDSSIQNITELVSRDVSLSTNILKLANSASFSQRARVEDLEDAIKVIGLSELNNILLSLGTKKILEEKYNEFEAIWERSSLSAFICRRLGERMGWKKQTITVLVCAALLHDVGRVILLSIDPNVSAKISEILGNRLYPSPLTLEEAALGISHTTLGGMICEKWNFSDTIRVAAEMHHRPLLVKREFQDTVFAIYLSDMIIDISSSISDYSMIQSAVLQHFGFKKEEEFVEFMDKTLLEYKDFP
>NZ_CP011934.1|WP_001058915.1|3821083_3821908_-|ABC-transporter-permease-subunit
MNNFSWIQDQIPKVFSIAFLTLRETLRKRVVYFIFIISALFLFLNFTCQIQIGSQDRSGNPDFQVYVTFLFFAFWNTVLALFLPVSLLGDELENKTYIPILARPVSPLTYIGGKSLGVLLLVFANGIFLIGTYLAKQQISGGNFSWDLLKACFTMFFVFYFLILFGFVIVLGFGKNVGFFGGLALLVFSTFLDLFIYESAAASMVQASDLKKQILEVIYWILPQEGTVFFFSSSLLAKSLSQVHYYGEYSLIQISVWVFLCFGFVKVILDRKEL
>NZ_CP011934.1|WP_001288326.1|3821900_3822815_-|ABC-transporter-ATP-binding-protein
MSEFAIEIDSIQKKYKEQKALKGVSFRVPKGSVFGLLGPNGAGKTSLVRILMGFSKQTEGNFRLFGLPFSTRLRQKIGYLPEKISIPGFLTGEEFLTFSGKLAGMKSALIRDKSKSLLEKTGIADAASKKVSGYSKGMLQRLGLASALISDPELLILDEPGSGLDPKGYIDFRETLVEENRIKGTTVLLNSHRLLEVEKVCHEIGILNLGTLAAIGPLESLKEGKNRILIKLESVTSELDSYIRKISSEQKIKENQIEFLPMGGIDLRKIPAELVALGANILKYERTTESLEEVFLRVTGGNDE
>NZ_CP011934.1|WP_000691324.1|3823022_3823505_+|phosphohistidine-phosphatase-SixA
MKIIIARHGEAETTSLDGTDRSRPLTAKGEADVRKMGNFFKTGFKITKIYHSPYERTKNTAKIYTDILQPEQETESLNYLEAGQDMSRVCPMIREYSNSDTILLVGHSPDVSIFAEKLLGISGVGKSFLFSPGSALAINVPREKFHDGQIIWFVCPDFLC

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP011934_1	1.1\|793210\|25\|NZ_CP011934\|CRISPRCasFinder	793210-793234	25	NZ_CP011934.1	1341622-1341646	1	0.96
NZ_CP011934_7	7.1\|3029106\|25\|NZ_CP011934\|CRISPRCasFinder	3029106-3029130	25	NZ_CP011934.1	3029528-3029552	2	0.92
NZ_CP011934_5	5.1\|1521560\|103\|NZ_CP011934\|CRISPRCasFinder	1521560-1521662	103	NZ_CP011934.1	1521483-1521585	43	0.583

1. spacer 1.1|793210|25|NZ_CP011934|CRISPRCasFinder matches to position: 1341622-1341646, mismatch: 1, identity: 0.96

gaaactcagcaaacacctccctaaa	CRISPR spacer
gaaactcagcaaacacttccctaaa	Protospacer
****************.********

2. spacer 7.1|3029106|25|NZ_CP011934|CRISPRCasFinder matches to position: 3029528-3029552, mismatch: 2, identity: 0.92

acgtaattctgtgggaactactgca	CRISPR spacer
acctaattctgtgggaactactaca	Protospacer
** *******************.**

3. spacer 5.1|1521560|103|NZ_CP011934|CRISPRCasFinder matches to position: 1521483-1521585, mismatch: 43, identity: 0.583

aaaagcgatgttgcaaaaagacaagcgtagcgtagacttttgctttcaacggagttgtaa	CRISPR spacer
aaaagcgatgttgcaaaaagacaagcgtagcgtagacttttgctttcaacggagttgtaa	Protospacer
************************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP011934_1	1.1\|793210\|25\|NZ_CP011934\|CRISPRCasFinder	793210-793234	25	NZ_CP020413	Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence	208013-208037	2	0.92
NZ_CP011934_1	1.1\|793210\|25\|NZ_CP011934\|CRISPRCasFinder	793210-793234	25	NZ_CP020413	Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence	52676-52700	2	0.92

1. spacer 1.1|793210|25|NZ_CP011934|CRISPRCasFinder matches to NZ_CP020413 (Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.92

gaaactcagcaaacacctccctaaa	CRISPR spacer
gaaactcagcaaacaccttcctaag	Protospacer
******************.*****.

2. spacer 1.1|793210|25|NZ_CP011934|CRISPRCasFinder matches to NZ_CP020413 (Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.92

gaaactcagcaaacacctccctaaa	CRISPR spacer
gtaactcagcaaacacctctctaaa	Protospacer
* *****************.*****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2506287 : 2515705

Enterobacteria_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000842260.1\|2506287_2507172_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	4.8e-97	60.3
WP_000723084.1\|2507172_2508222_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	5.3e-95	51.2
WP_000642169.1\|2508218_2509139_-	dTDP-4-dehydrorhamnose reductase	NA	NA	NA	NA
WP_001159758.1\|2509142_2509703_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	3.5e-45	52.9
WP_000854005.1\|2509899_2511648_-	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	7.7e-06	33.3
WP_000282880.1\|2512372_2513194_-	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	2.4e-10	30.0
WP_000560749.1\|2513703_2514501_-	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	2.7e-06	35.6
WP_000575184.1\|2514613_2515705_-	DegT/DnrJ/EryC1/StrS family aminotransferase	A0A2P1ELT3	Moumouvirus	2.4e-37	31.6

DBSCAN-SWA_2

2568697 : 2578309

uncultured_Mediterranean_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001230567.1\|2568697_2569732_-	N-acetylneuraminate synthase	A0A1B1IVE2	uncultured_Mediterranean_phage	4.5e-30	34.9
WP_000516589.1\|2569709_2570330_-	acetyltransferase	NA	NA	NA	NA
WP_000947842.1\|2570322_2571486_-	LegC family aminotransferase	A0A2D2W2B8	Stenotrophomonas_phage	5.3e-11	26.4
WP_000600886.1\|2571485_2572478_-	SDR family NAD(P)-dependent oxidoreductase	A0A1V0SKV4	Klosneuvirus	2.1e-24	29.2
WP_000132017.1\|2572480_2573167_-	acylneuraminate cytidylyltransferase family protein	A0A1B1IVD3	uncultured_Mediterranean_phage	3.0e-14	38.0
WP_000797355.1\|2573163_2574951_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	8.7e-29	28.4
WP_000947527.1\|2574962_2576048_-	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	1.1e-05	29.1
WP_000707057.1\|2576034_2576970_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_000572390.1\|2576966_2577371_-	WxcM-like domain-containing protein	NA	NA	NA	NA
WP_000025488.1\|2577367_2578309_-	NAD(P)-dependent oxidoreductase	L7RCI0	Acanthamoeba_polyphaga_moumouvirus	3.9e-20	27.9

DBSCAN-SWA_3

3222853 : 3237260

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033109426.1\|3222853_3223783_+	hypothetical protein	S5W9G5	Leptospira_phage	2.4e-14	67.1
WP_025176346.1\|3223849_3224701_-	hypothetical protein	S5W9A4	Leptospira_phage	7.9e-105	68.4
WP_000501191.1\|3225261_3226257_-	RHS repeat-associated core domain-containing protein	S5W9C6	Leptospira_phage	1.3e-82	67.3
WP_000833415.1\|3226737_3233703_-	membrane protein	S5W9E6	Leptospira_phage	0.0e+00	69.0
WP_000162776.1\|3234005_3234890_+	hypothetical protein	S5VSU6	Leptospira_phage	1.7e-134	80.6
WP_001058884.1\|3234886_3236626_+	hypothetical protein	S5VKK9	Leptospira_phage	8.2e-226	83.2
WP_000835589.1\|3236633_3237260_+	tetratricopeptide repeat protein	S5VKQ0	Leptospira_phage	3.1e-50	57.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP011935

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

172232 : 259561

Pseudomonas_phage(20.0%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000264274.1\|172232_173120_+\|protease	protease HtpX	NA	NA	NA	NA
WP_000029425.1\|173641_174175_+	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	8.0e-31	45.2
WP_000125239.1\|174212_175727_+\|protease	serine protease	A0A1V0CPG8	Kaumoebavirus	1.1e-19	25.1
WP_000944580.1\|175741_177325_+	PDZ domain-containing protein	NA	NA	NA	NA
WP_000599977.1\|178692_179925_-	hypothetical protein	NA	NA	NA	NA
WP_001083728.1\|179921_181499_-	hypothetical protein	NA	NA	NA	NA
WP_000444125.1\|181495_181888_-	transcriptional repressor	NA	NA	NA	NA
WP_000466210.1\|182587_182779_-	hypothetical protein	NA	NA	NA	NA
WP_000050533.1\|183578_184256_+	biliverdin-producing heme oxygenase	M4QDD1	Prochlorococcus_phage	2.6e-42	42.5
WP_000612015.1\|184230_185448_+	MFS transporter	NA	NA	NA	NA
WP_048657678.1\|186535_187429_-\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_000449680.1\|188082_190215_-	TonB-dependent receptor	NA	NA	NA	NA
WP_001079027.1\|190193_190895_-	hypothetical protein	NA	NA	NA	NA
WP_001226849.1\|190919_191498_-	hypothetical protein	NA	NA	NA	NA
WP_000614777.1\|191970_192696_+	leucine-rich repeat domain-containing protein	NA	NA	NA	NA
WP_002039127.1\|192708_193461_-	hypothetical protein	NA	NA	NA	NA
WP_000492446.1\|193899_194205_-	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_000691276.1\|194309_195665_-	membrane protein	NA	NA	NA	NA
WP_000595826.1\|195922_197545_-	AAA family ATPase	NA	NA	NA	NA
WP_000897623.1\|197570_198629_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_033108649.1\|198860_200270_+	DUF2029 domain-containing protein	NA	NA	NA	NA
WP_001122445.1\|200289_201432_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_000812268.1\|201436_202009_+	hypothetical protein	NA	NA	NA	NA
WP_000632689.1\|202441_203827_+	hypothetical protein	NA	NA	NA	NA
WP_000898542.1\|203898_205311_+	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	1.0e-56	33.9
WP_000666151.1\|205325_206486_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_000578215.1\|206482_207880_+	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	6.7e-61	38.0
WP_002156778.1\|207889_208957_+	DUF1574 domain-containing protein	NA	NA	NA	NA
WP_001004760.1\|208953_209298_+	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_000739911.1\|210057_210471_-	biopolymer transporter ExbD	NA	NA	NA	NA
WP_000453426.1\|210467_210995_-	MotA/TolQ/ExbB proton channel family protein	NA	NA	NA	NA
WP_000012762.1\|211606_212356_+	ubiquinone/menaquinone biosynthesis methyltransferase	NA	NA	NA	NA
WP_000721922.1\|212495_214589_+	LruC domain-containing protein	NA	NA	NA	NA
WP_000928212.1\|214633_216025_+\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_000835115.1\|216007_218107_-	hypothetical protein	NA	NA	NA	NA
WP_000125526.1\|218922_219375_-	TraR/DksA family transcriptional regulator	NA	NA	NA	NA
WP_001206796.1\|219392_219557_-	50S ribosomal protein L33	NA	NA	NA	NA
WP_000366213.1\|220152_221046_-\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_048657722.1\|222676_225535_+	DUF1566 domain-containing protein	NA	NA	NA	NA
WP_010679676.1\|225651_226188_+	DUF1566 domain-containing protein	NA	NA	NA	NA
WP_000995311.1\|227301_228525_+	AraC family transcriptional regulator	S5VXW9	Leptospira_phage	2.1e-26	31.0
WP_001070551.1\|230416_230818_-	hypothetical protein	NA	NA	NA	NA
WP_000528391.1\|232225_233944_-	REC domain-containing phosphodiesterase	NA	NA	NA	NA
WP_000739836.1\|234410_236093_-	sensor domain-containing diguanylate cyclase	A0A127AWB9	Bacillus_phage	3.3e-22	34.8
WP_001103846.1\|236389_237958_-	sensor domain-containing diguanylate cyclase	A0A127AWB9	Bacillus_phage	3.9e-17	35.1
WP_000597515.1\|238488_241014_+	response regulator	A0A1V0SGX0	Hokovirus	3.9e-51	37.2
WP_000723987.1\|241496_242198_-	FecR domain-containing protein	NA	NA	NA	NA
WP_001068354.1\|242240_242648_-	hypothetical protein	NA	NA	NA	NA
WP_001134756.1\|242930_243935_-	patatin-like phospholipase family protein	NA	NA	NA	NA
WP_025176383.1\|244389_245778_-	sodium:solute symporter family protein	NA	NA	NA	NA
WP_000491581.1\|246186_246558_+	hypothetical protein	NA	NA	NA	NA
WP_000925580.1\|246821_248279_+	hypothetical protein	NA	NA	NA	NA
WP_000757100.1\|248528_248810_-	TIGR04454 family lipoprotein	NA	NA	NA	NA
WP_000391762.1\|248806_250771_-	cellulase family glycosylhydrolase	NA	NA	NA	NA
WP_000816747.1\|250898_251777_-	patatin-like phospholipase family protein	A0A161HUS6	Powai_lake_megavirus	1.7e-06	43.2
WP_000119694.1\|252573_252993_+	hypothetical protein	NA	NA	NA	NA
WP_000094629.1\|253344_254559_-	MFS transporter	NA	NA	NA	NA
WP_001211395.1\|255072_256362_+	acetyl-CoA hydrolase/transferase family protein	NA	NA	NA	NA
WP_001049247.1\|256690_257149_+	hypothetical protein	NA	NA	NA	NA
WP_001221437.1\|257161_259561_+\|protease	cysteine protease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP011936

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP011934

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP011935

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection