CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP011329	Streptococcus agalactiae strain H002 chromosome, complete genome	3 crisprs	cas3,DinG,cas9,cas1,cas2,csn2,csm6,DEDDh,csa3	3	14	8	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP011329_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011329_1

625398-625614

Orphan

Consensus_repeat	Method
TCTGGAATGGGATCAAAGC	CRT

3 spacers

The CRISPR arrays of NZ_CP011329_1

>merge|NZ_CP011329|1|625398-625614|CRT
CCTGGAATGGGATCAAAGGCACCATGACAAACTTACTTAATAGTATCAAATCTGTCGTTAGTAATGTCTGGAATGGCATCAAATCCACGATTAGTTCCATTCTATCGAGTATTGGTTCAACGGTATCTTCTATCTGGAATGGGATGAAAGCAACCATCTCAGGTGTCCTAAGTGGTATTTCAAACACAGTGACCTCTGTCTGGAATGGGGTCAAAGC

>NZ_CP011329|1|1|625398-625614|CRT
CCTGGAATGGGATCAAAGG	CACCATGACAAACTTACTTAATAGTATCAAATCTGTCGTTAGTAATG
TCTGGAATGGCATCAAATC	CACGATTAGTTCCATTCTATCGAGTATTGGTTCAACGGTATCTTCTA
TCTGGAATGGGATGAAAGC	AACCATCTCAGGTGTCCTAAGTGGTATTTCAAACACAGTGACCTCTG
TCTGGAATGGGGTCAAAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011329.1\|WP_000987322.1\|620386_620644_+\|phage-gp6-like-head-tail-connector-protein	unknown	unknown	gnl\|CDD\|153446
NZ_CP011329.1\|WP_001225240.1\|618469_619168_+\|Clp-protease-ClpP	unknown	unknown	gnl\|CDD\|132927
NZ_CP011329.1\|WP_000796402.1\|629744_631601_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|310464
NZ_CP011329.1\|WP_050881953.1\|619181_620390_+\|phage-major-capsid-protein	unknown	unknown	gnl\|CDD\|273690
NZ_CP011329.1\|WP_000705390.1\|620643_620982_+\|head-tail-adaptor-protein	unknown	unknown	gnl\|CDD\|377521
NZ_CP011329.1\|WP_000149738.1\|616793_617120_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011329.1\|WP_000290966.1\|634205_635447_+\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|214861
NZ_CP011329.1\|WP_000818566.1\|621680_622250_+\|phage-tail-protein	unknown	unknown	gnl\|CDD\|273713
NZ_CP011329.1\|WP_000589858.1\|626091_626817_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227066
NZ_CP011329.1\|WP_000523693.1\|617187_618477_+\|phage-portal-protein	unknown	unknown	gnl\|CDD\|377413
NZ_CP011329.1\|WP_001209973.1\|621351_621678_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011329.1\|WP_000966166.1\|626816_629732_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227263
NZ_CP011329.1\|WP_000123549.1\|633560_633668_+\|putative-holin-like-toxin	unknown	unknown	gnl\|CDD\|319017
NZ_CP011329.1\|WP_000132373.1\|636778_637849_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011329.1\|WP_000661350.1\|631618_632017_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377457
NZ_CP011329.1\|WP_000672531.1\|637870_639169_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011329.1\|WP_000161243.1\|620974_621343_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011329.1\|WP_001249615.1\|622261_622681_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011329.1\|WP_001142755.1\|639386_639608_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011329.1\|WP_079457400.1\|635391_636696_+\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|238206

Protein	Function_ID	Function_description	E-value
NZ_CP011329.1\|WP_000987322.1\|620386_620644_+\|phage-gp6-like-head-tail-connector-protein	gnl\|CDD\|153446	cd08054, gp6, Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins. The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. It forms a dodecameric ring structure that comprises the middle ring of the connector, located between the portal protein (attached to the head) and the gp7 ring (attached to the tail). It is a component of the mature phage and the absence of HK97 gp6 results in defective head-tail joining and the absence of mature phage particles. Although the crystal structure of HK97 gp6 shows an unexpected 13-mer ring, the biological form present in the mature phage is believed to be a dodecamer.	4.56115e-12
NZ_CP011329.1\|WP_001225240.1\|618469_619168_+\|Clp-protease-ClpP	gnl\|CDD\|132927	cd07016, S14_ClpP_1, Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease. Clp protease (caseinolytic protease; ClpP; Peptidase S14) is a highly conserved serine protease present throughout in bacteria and eukaryota, but seems to be absent in archaea, mollicutes and some fungi. This subfamily only contains bacterial sequences. Clp proteases are involved in a number of cellular processes such as degradation of misfolded proteins, regulation of short-lived proteins and housekeeping removal of dysfunctional proteins. They are also implicated in the control of cell growth, targeting DNA-binding protein from starved cells. ClpP has also been linked to the tight regulation of virulence genes in the pathogens Listeria monocytogenes and Salmonella typhimurium. This enzyme belong to the family of ATP-dependent proteases; the functional Clp protease is comprised of two components: a proteolytic component and one of several regulatory ATPase components, both of which are required for effective levels of protease activity in the presence of ATP, although the proteolytic subunit alone does possess some catalytic activity. Active site consists of the triad Ser, His and Asp; some members have lost all of these active site residues and are therefore inactive, while others may have one or two large insertions. ClpP seems to prefer hydrophobic or non-polar residues at P1 or P1' positions in its substrate. The protease exists as a tetradecamer made up of two heptameric rings stacked back-to-back such that the catalytic triad of each subunit is located at the interface between three monomers, thus making oligomerization essential for function.	8.97496e-75
NZ_CP011329.1\|WP_050881953.1\|619181_620390_+\|phage-major-capsid-protein	gnl\|CDD\|273690	TIGR01554, prophage_Lp3_protein_18, phage major capsid protein, HK97 family. This model family represents the major capsid protein component of the heads (capsids) of bacteriophage HK97, phi-105, P27, and related phage. This model represents one of several analogous families lacking detectable sequence similarity. The gene encoding this component is typically located in an operon encoding the small and large terminase subunits, the portal protein and the prohead or maturation protease. [Mobile and extrachromosomal element functions, Prophage functions].	6.50086e-117
NZ_CP011329.1\|WP_000705390.1\|620643_620982_+\|head-tail-adaptor-protein	gnl\|CDD\|377521	pfam05521, Phage_H_T_join, Phage head-tail joining protein.	4.12549e-13
NZ_CP011329.1\|WP_000966166.1\|626816_629732_+\|hypothetical-protein	gnl\|CDD\|227263	COG4926, PblB, Phage-related protein [Function unknown].	2.14498e-33
NZ_CP011329.1\|WP_000290966.1\|634205_635447_+\|recombinase-family-protein	gnl\|CDD\|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	2.0642e-37
NZ_CP011329.1\|WP_000796402.1\|629744_631601_+\|hypothetical-protein	gnl\|CDD\|310464	pfam05895, DUF859, Siphovirus protein of unknown function (DUF859). This family consists of several uncharacterized proteins from the Siphoviruses as well as one bacterial sequence. Some of the members of this family are described as putative minor structural proteins.	0
NZ_CP011329.1\|WP_000589858.1\|626091_626817_+\|hypothetical-protein	gnl\|CDD\|227066	COG4722, COG4722, Phage-related protein [Function unknown].	5.34034e-05
NZ_CP011329.1\|WP_000523693.1\|617187_618477_+\|phage-portal-protein	gnl\|CDD\|377413	pfam04860, Phage_portal, Phage portal protein. Bacteriophage portal proteins form a dodecamer and is located at a five-fold vertex of the viral capsid. The portal complex forms a channel through which the viral DNA is packaged into the capsid, and exits during infection. The portal protein is though to rotate during DNA packaging. Portal proteins from different phage show little sequence homology, so this family does not represent all portal proteins.	3.28187e-127
NZ_CP011329.1\|WP_000123549.1\|633560_633668_+\|putative-holin-like-toxin	gnl\|CDD\|319017	pfam16935, Hol_Tox, Putative Holin-like Toxin (Hol-Tox). Hol_Tox is a family of small proteins (34-48aas) with a single TM region. Members can exhibit antibacterial activity against Gram-positive bacteria but not against Gram-negative bacteria.	0.000621774
NZ_CP011329.1\|WP_000661350.1\|631618_632017_+\|phage-holin-family-protein	gnl\|CDD\|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	1.16717e-38
NZ_CP011329.1\|WP_000818566.1\|621680_622250_+\|phage-tail-protein	gnl\|CDD\|273713	TIGR01603, Uncharacterized_phage_related_protein, phage major tail protein, phi13 family. This model describes a set of proteins that share low levels of sequence similarity but similar lengths and similar patterns of charged, hydrophobic, and Gly/Pro residues. All members (except one attributed to mouse embryo cDNA) belong to phage of Gram-positive bacteria. Several are identified as phage major tail proteins. Some members of this family have additional C-terminal regions of about 100 residues not included in this model. [Mobile and extrachromosomal element functions, Prophage functions].	2.24087e-23
NZ_CP011329.1\|WP_079457400.1\|635391_636696_+\|recombinase-family-protein	gnl\|CDD\|238206	cd00338, Ser_Recombinase, Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.	1.64916e-45

>NZ_CP011329.1|WP_001249615.1|622261_622681_+|hypothetical-protein
MRQNITIAGKTYPLATNAYTPIAYKEQFGKDYFQELFNMLSAESIMAQLEQLDEGEELKASQIDLSILSDFDITFFHRLFWVFAKSANPRIKPFEDFFMSMEEFPLQEVGPVLMSMLNQGMTTRKKQITQNQRARKSSR
>NZ_CP011329.1|WP_000818566.1|621680_622250_+|phage-tail-protein
MAEKNKVTFGLQDVHWAEVTNERADGALTYGTVERLRGAAELTLEPTGDKGSYKADNINFYTTESNDGYEGTLKVALLSQEFLTRVLGEKLDATTNTISEIANSEKKNFALMFRFEGDKKETLHVLYYCYASRPTVGSKTKSGSDINEVELTFTASPRPLDKIVRRRTTEETSDEIRENWFKSVFEPTT
>NZ_CP011329.1|WP_001209973.1|621351_621678_+|hypothetical-protein
MRFEELFPVLKKTKLPVAYHHFEEGHSPSPPFMVYLVTDSDNLGADNWAYHKTINLQIELYTTKKDLATEKTVESLLDAHRLHFDKVEIYIANEKLYQTIYSITLLGG
>NZ_CP011329.1|WP_000161243.1|620974_621343_+|hypothetical-protein
MTKIGLDDLASVIEKELTTYAKETTDTMREVVEEVTDDAVETLKVTSPKRRGKYAKGWTSKATTDTNTALTKTIHNRTPGLTHLLEDGHAKQNGGRVEGRKHISPVEKKAIQSFEDKLRQKL
>NZ_CP011329.1|WP_000705390.1|620643_620982_+|head-tail-adaptor-protein
MKITPLREQLVFQEKRLRQDDIGNEAAIWDDLFMRWCSCRPMALTESDGSATKIVHNKVQFTLRYDKKVLALNSLTTRIYFRDQYYAIESLDGDTVPRRLIYVVATKEEIYD
>NZ_CP011329.1|WP_000987322.1|620386_620644_+|phage-gp6-like-head-tail-connector-protein
MMSLEEVKLYLKVENDEEDFLIEQLMTSSRQLCLDIIRETSTSEVLKTAILYGVAYLYEHREEASHKELKETLYHLLLADRKEVF
>NZ_CP011329.1|WP_050881953.1|619181_620390_+|phage-major-capsid-protein
MSKLLELKEKRNAAWAQAKAFLDTVRSEDGLVSDEDAKRYEEMEAKIELYNKEIARLERQEKIDLELAQPTSQALTTQPTVIVDNQKEDEKKGVASDIYTQTFWTSIRKRHFYDVKDVLRVGEDTEGGHLVPDEYEKKLVQGLQEENFFRSLATVIKTSSGERKIPVVTGHGSASWMDENGLYPETDETFGQVTFDSHKIGTAIRISEELLNDSVFDLESYMTSEFARRIGTEEEKSFLVGDGSKKPTGIFTQADVEGPTTSTKDITFDDMIELYHSLPAPYRKNAVWVLHDTTVKAIRKLKDNNGNYIWQPSTQAGQPDLILNRPYYTSTFAPLPEAGNKAIAFGDFSYYWIADRQGRTFKRLNELYANNGQIGFLASQRVDGKLVLPEAVKVLTVKGKAV
>NZ_CP011329.1|WP_001225240.1|618469_619168_+|Clp-protease-ClpP
MRKFWNFTDQGDVRTLRIEGQIADETWFGDEVTPQLFKNDLSAGTGDITLWINSPGGDVFAAAQIYNMLMDYKGDVHVIIDGLAASAASVIAMAGTTVSMSPVAMMMIHNPWTFAQGEAKDMAKVIEMLGEIKESIINAYEIKTGLSRTKISHLMDSESWFNAKKAVELGFADKVLFEKEETPEQDHQNSYTFSRVTASHDLVVKLQASLQPPKPQKTIPFNQLEKRLNLLK
>NZ_CP011329.1|WP_000523693.1|617187_618477_+|phage-portal-protein
MGLLDSLGRKRARDKPKNSYEGQDFSYLFGRTTSGENVDEFKAMQTTAVYACVRILAEAVASLPIHVYELTSNGKEKKIDHPLYFLLHDEPNPEMSSFIFRETIMSHLLIWGNAYVQIIRDKAGRVISLYPLLPDKMSIHRDGSGKLYYKYQRQTEENPNFKDKGTVLLKQENILHVPGLGFDGLIGYSPVAMVKNAIGMTLATENYGAAFFKNGANPGGVLEHPGILKDPKRVRDSWNAVYNGATNAHKVAVLEEGMKYTQVGIPPEEAQFLQTRKFQINEIARLYRIPPHMVGDLEKSSFSNIEQQSLEFVKYTLDPWVVRLEQAFKRSLFLPEEKKRYLIKFNVDGLLRGDYQSRMNGYAIARQNGWLSTNDIRELEDLNLLSDEEGGNLYLINGNMTKLKDAGGFMKQPTETESAEDPPEEEEDA
>NZ_CP011329.1|WP_000149738.1|616793_617120_+|hypothetical-protein
MTHSILSLEVENELLSSVREVCAEYDLKLEELVKDYLGFLAGLNASAIEQVSALPNENEKAEWLAKYYFDARINQLQFEALKKEVLIGHDQIKESKVTRLEDVRHEFD
>NZ_CP011329.1|WP_000589858.1|626091_626817_+|hypothetical-protein
MIKHNELVLNGKGTSSFPFKVLVEDRPSIQVPRSKTQLLDHRGLSGAIVQTNKHRDAIEKPYRMYLIGASEKEVNEFSAYLMQEGFWLESERLKLTRLWCYRTDSFDIKQDDHDVYVTDVVFICHPTRFFKSVDRQVLSANGVLKTQGSALAFPTITITGQSVSETSFTVGDQVVRIEKFTEPLVMVNHPDRPSFKTLSGKAVKWSGDFITIDASHSTQSVGVILGSGILSLTFETNWGWV
>NZ_CP011329.1|WP_000966166.1|626816_629732_+|hypothetical-protein
MLYLLDGQTKTAKWNGQPLFETVSATVEEELNGTFQLRLTYPITDSGVHEILRADELILCPTPDLGKQLFRIKQAKIQDDMVELECYHISDDVMKRQIKPFSATNTTCQSALMRLVEACPSDLGLFSFDSDVTERHTYVSDENLTLYQALMDGKHSLLGTWEGELVRDNFQLMVKKYRGIDKGVILTSHHNLKTFEDKGDSEKVITRIYATSTFQVEGSDEDTVLSVVVESPLINQYPYVHEARYENNTLQTEEELRQWAMAKFTHEHIDSISRQITVEAYQLDGQEVHLGDTVTLKSQKHKVDVRKKAVGYTFDALEEVYLSVTFDDEVSFTTSGLSGTHSLTSAAKTILNVNQSVTEHRASKERANFNKVFDRQFERLQTEVEDGIAIAKAEGERSGKKAALDYLATDALEARVAALQKATIDELTVSSSAWMTRLVSQQILSEYAKSLEVEADRVVIPGQHTPVFSLDRDGNLSIDTPLLKVRGESLATTADLKTISLTPGPKGEAGEDGVGIQSREQYYLVSAQKTGLTTTSSGWSKTIPSLTSALKYLWNYEKTTFTNGSTTVTTPIVIGVYGDKGVDGKAGKDGKTLYTWRMYADSDKGEGLSAIPTGKRYLGLAVNRESATSSTNPSDYTWSSFFEGTELGGRNYIDDYAMKAATFSSVTSEWKKEVVEDTSSVSGVTVKMTCTKAGTGGFHRNFYDLRNRIGANKTFSVDLKASKAVSLTIGNELGGTKVVQVSPSWQRYSVSWKVGSAQNHSYVFYLKSGTWAVGDVVYLRNVQLEDGNVASAPGPSLNDLIAQIDAKADNGFMKQQLDLLTEKTESLRVDLEARALAKEVADWLKSYKEFEKNNEAVLAQFNQDFIDNTARIAAIEADLKANSLLLNFVNTYLRAGDNGVIIGKKDNSEVIELTPQGMMIRSAGNAVMTVTAGVIKIHHGVFVETLQVGYYRLEAARHNAKHLVCRFIDAK
>NZ_CP011329.1|WP_000796402.1|629744_631601_+|hypothetical-protein
MADYGSNNDRGYTLLLRVEETGTSTADNTSTVRVQLWLKNGYTTFGMYDCRASVSINGQTLSWSGRPDMYTAHSSLHLIDKTITVPHDSNGSKTISFSATFSGSGGWSPGTLNTGSQLLRLSDIPRSSSATVSGNMMGQAVTITIKRASSDFTHNMTWHFGSLSGTIGTGIATSATWMPSISQLATQIPNSASGNGHLTLATIYGGKTIGSMTIPITLNLPASVVPTLGGISVSESHVTAKTILTGTSFAQLVSNPKVTFNQGAGIYGSTTPSTGYRAEVFKFENNQWVQLPNVATSNNGLLGGINWIGRAKVSAYVIDSRGRQSARKEVEITLLEYFKPIFSFSAVRAGSSMNQVTVTRKLKIAPLTISNVQKNKATLTWEVVDLSSGQKVTNAGGAANWTSTTEHTKMDFQAILGGTYDTTKSYTIIGTLADLFYSTTFEFTIGPEKVVYGLSPSGMGIGKAWTRGVLDVDGSLPAYFDGDIYMKNKKLLDIFYPVGVIYESTSSTSPATIMGGTWERFGNGRVLVGVSENESEFNSVNQSGGSKTHTLTIDEMPSHSHAQYVTANNGSGAIRRDHSSDGSSSLYPQGNNTGNTGGGKPHNNLQPYVTVYRWRRTA
>NZ_CP011329.1|WP_000661350.1|631618_632017_+|phage-holin-family-protein
MKELLATNKVLFSAIGGLIGSIFGEVDGFLFALMVFISIDYITGLMAAAVEKKLASNIGFKGIFKKIVLLFLVAVGQIIDEHVLKQGGVVRTAIIFYYLSNEGLSIIENAARIGLPVPEKLKDVLKQLKQGD
>NZ_CP011329.1|WP_000123549.1|633560_633668_+|putative-holin-like-toxin
MTAFEVVQIIIGFGSFTVALIGLCYKIFKDDDKKK
>NZ_CP011329.1|WP_000290966.1|634205_635447_+|recombinase-family-protein
MAVRLIKTKSNRKKQRVCAYTRVSTTNSSQLDSLENQKAYFENLYTNRVDVDFLGVYYDKGISGSKAERPSFQAMLEACRQGQIDLIHTKSISRFARNTMTVLEVSRELKVLGVGIYFEEQNINTLSNEGEVMLSVLASLAEEELQSMSDNQRWAFQRKFQRGEMVINTKRFMGYDVDDKGELVINEAEAQIVRRIFQLYLDGMGMHRIAKLLNQENVPTVTDAKWHDTTVRNILKNEKYKGTVLLQKYFHVGINGPKRLNQGQVEQYLIEDNHEPIVSKEVWQAVQDKLASKTWKQGVNKHYRFTSMLKCEYCGSTLKRQVTYKKQIVWCCSKYIKEGKASCRGMRVPEKAIEEWKLKTPVTVIERNEYGQKHYSYSSQESAADGHPSASNQNKSGSLLSGVHRPRRTAIKL
>NZ_CP011329.1|WP_079457400.1|635391_636696_+|recombinase-family-protein
MAAYCRVSTDQDEQLSSYENQVSYYRDYILKHEDYELVDIYADEGISATNTKKREAFNRLIQDCRAGKVDRILVKSISRFARNTLDCIKYVRELKELGIGVTFEKENIDSLDSKGEVLLTILSSLAQDESRSISENATWGIRKKFERGEVRVNTTKFMGYDKDENSRLVINPEQANVVKHIYNQFLDGFGPESIAKEFNAKGIKGWSGKANWYPSAILKMLQNEKYKGDALLQKTYTVDFLTKKRTENTGQVNQYYVANNHEAIISKELWETVQLEIARRKAFREEHKLVFYIMQSDDNPFTTKVFCAECGSAFGRKNWTTSRGKRKVWQYNNRYKVKGQIGCQNNHIDEEMLEKAFLKAVELLQEHRADVVVKWQKLEKGTNLLHKHYAKQMYQLLELDVFDGTIMNQVLDHIIISENGQISVKFLEGTEIDL
>NZ_CP011329.1|WP_000132373.1|636778_637849_+|hypothetical-protein
MTDSNEVKKVERDSIKIAVDSVANLSEKIKLGQNTAAISVLADTLSNFQATVASSNISGFIAASNALTTSKLVNIANLTTPLASLTSSIQMEKSAINAMSEVIDSYNKIWSSAHLQAIQNIAESSKKLIASYQIDYSKIFSNINELLKSLPSTYTQEEIEQITSGVQLLAENGWVIYFRDRNVYQRVLAEEWDVLEEEWVELLRENLKDETSIVDLQNSPCYSDPLVKSMVDCYLNQNYYAAYTLGSLAIDGALNRISEMISSRKKIPVGYKAVEEIDAIFIDKSFSDIGLMHWLYNFFKDTNRFTLDEPNRHMVGHGRWEKEIDETDFLKLFNTLLYIYDEYGYWSEIIETDRLK
>NZ_CP011329.1|WP_000672531.1|637870_639169_+|hypothetical-protein
MKFSKIFKIILLLTGLVLSLLFWKILVNLVVSTNIEVSQGNLYLLAIIFWLELLFLLAIYDLVIIELYSGISYYLSKLGQLAVRTKKVRLALYIIRLNYYLLRLSKLLRIGWVTYGSGEKSSVWIGLSKLSLTQLSLNIFKLVISAPMLLAFLSACFSLKILRGGDIINYLSKHQEFLRGILQLKVNIGDVFSRLPAFVALMTILPVVFFFYFFSQKRDVRKIIDKENSQYFEEVVLLYEKLLIWIDNHIYKLSENFDYVIKCQDSIVEVFLKKEIRNYIELIDKRYYIPRRIEEFRFIEIADLTELREIITKLTSDRLVKFTRIFSVKQFDIWYLYFGDFHTLREEERVEMSFCTKTGISSKLDKRHTYPYDFTQGQIEKRRNEELSLLSWSIYDSLELLYRLKRTSDSLRKYLYSSRTERLILKALSKDK
>NZ_CP011329.1|WP_001142755.1|639386_639608_+|hypothetical-protein
MPTMQLLDELVLPKDITIADVSQSIQEFEIERDALQEFFDDMLKTYTTYQEMKDYIKSREANTPKQETEEKSL

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Crispr_ID: NZ_CP011329_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011329_2

921391-922548

TypeII

II-A

Consensus_repeat	Method
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	PILER-CR
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CRISPRCasFinder
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CRT

17 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_CP011329_2

>merge|NZ_CP011329|2|921391-922548|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACAGTTATCAATGCTATATGGTTTCTCATCTTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACGTTTAATTTTGAATAATATCATGTTTACTCGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTATGTCATTGTGATTGTGGGAATACTTGTGGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACGGCGAACTTGTAACGTTTGACGGTAATTTTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTAATGTCTTTTCCTAGAATGTACATTTCTAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACATTACTTTCAAGATGTCTATGACTATATGCGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTATTTCATCATAGAAAATCCTGCTAGTGGTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACGCGATGATGGTAAGTCATCATGGACAGCGTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTTTTACACACGATGTCAGATATAATGTCAAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACAGTACTGCACTAGGAATTGTAGAGATCAAAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACCGTACCATCTATCAATTTACCGCAAGCTGTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTTGCTGCTAGACCCAAACAGTTTATTTTTAGGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTCCTTTTTTAGATAATGTGCGATCACGGACGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTTTTACCAATGCTTCCATATCGCTTATATGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTACTTGACGAATTGAAGATGACGGAATTTAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTGGTTATACATTTACTAATCCATCAGCATTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACAAGCTAATTCTCATCTCACCGAGATGGATAGTTTTAGAGCTGTGCTGTTATTATGCTAGGACATCA

>NZ_CP011329|2|1|921391-922416|PILER-CR
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGTTATCAATGCTATATGGTTTCTCATCTT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GTTTAATTTTGAATAATATCATGTTTACTC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TATGTCATTGTGATTGTGGGAATACTTGTG
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGCGAACTTGTAACGTTTGACGGTAATTTT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TAATGTCTTTTCCTAGAATGTACATTTCTA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	ATTACTTTCAAGATGTCTATGACTATATGC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TATTTCATCATAGAAAATCCTGCTAGTGGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GCGATGATGGTAAGTCATCATGGACAGCGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TTTTACACACGATGTCAGATATAATGTCAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGTACTGCACTAGGAATTGTAGAGATCAAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CGTACCATCTATCAATTTACCGCAAGCTGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TTGCTGCTAGACCCAAACAGTTTATTTTTAG
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCCTTTTTTAGATAATGTGCGATCACGGAC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TTTTACCAATGCTTCCATATCGCTTATAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TACTTGACGAATTGAAGATGACGGAATTTA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC

>NZ_CP011329|2|1|921391-922482|CRISPRCasFinder
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGTTATCAATGCTATATGGTTTCTCATCTT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GTTTAATTTTGAATAATATCATGTTTACTC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TATGTCATTGTGATTGTGGGAATACTTGTG
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGCGAACTTGTAACGTTTGACGGTAATTTT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TAATGTCTTTTCCTAGAATGTACATTTCTA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	ATTACTTTCAAGATGTCTATGACTATATGC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TATTTCATCATAGAAAATCCTGCTAGTGGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GCGATGATGGTAAGTCATCATGGACAGCGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TTTTACACACGATGTCAGATATAATGTCAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGTACTGCACTAGGAATTGTAGAGATCAAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CGTACCATCTATCAATTTACCGCAAGCTGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TTGCTGCTAGACCCAAACAGTTTATTTTTAG
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCCTTTTTTAGATAATGTGCGATCACGGAC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TTTTACCAATGCTTCCATATCGCTTATAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TACTTGACGAATTGAAGATGACGGAATTTA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGGTTATACATTTACTAATCCATCAGCATT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC

>NZ_CP011329|2|2|921391-922548|CRT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGTTATCAATGCTATATGGTTTCTCATCTT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GTTTAATTTTGAATAATATCATGTTTACTC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TATGTCATTGTGATTGTGGGAATACTTGTG
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGCGAACTTGTAACGTTTGACGGTAATTTT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TAATGTCTTTTCCTAGAATGTACATTTCTA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	ATTACTTTCAAGATGTCTATGACTATATGC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TATTTCATCATAGAAAATCCTGCTAGTGGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GCGATGATGGTAAGTCATCATGGACAGCGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TTTTACACACGATGTCAGATATAATGTCAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGTACTGCACTAGGAATTGTAGAGATCAAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CGTACCATCTATCAATTTACCGCAAGCTGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TTGCTGCTAGACCCAAACAGTTTATTTTTAG
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCCTTTTTTAGATAATGTGCGATCACGGAC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TTTTACCAATGCTTCCATATCGCTTATAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TACTTGACGAATTGAAGATGACGGAATTTA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGGTTATACATTTACTAATCCATCAGCATT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AAGCTAATTCTCATCTCACCGAGATGGATA
GTTTTAGAGCTGTGCTGTTATTATGCTAGGACATCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011329.1\|WP_000621142.1\|930902_931367_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP011329.1\|WP_000159234.1\|910772_911144_+\|YbgA-family-protein	unknown	unknown	gnl\|CDD\|377982
NZ_CP011329.1\|WP_000146565.1\|935968_936607_-\|CatB-related-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100040
NZ_CP011329.1\|WP_000523795.1\|912774_913512_+\|acyl-ACP-thioesterase	unknown	unknown	gnl\|CDD\|366738
NZ_CP011329.1\|WP_050881965.1\|915316_919429_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|273840
NZ_CP011329.1\|WP_001241816.1\|911168_911549_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131381
NZ_CP011329.1\|WP_000323544.1\|913512_914283_+\|TIGR01457-family-HAD-type-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP011329.1\|WP_000665410.1\|931366_931801_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|234692
NZ_CP011329.1\|WP_000168898.1\|931952_934745_+\|cation-transporting-P-type-ATPase	unknown	unknown	gnl\|CDD\|223550
NZ_CP011329.1\|WP_151383509.1\|929223_930135_+\|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|380192
NZ_CP011329.1\|WP_000438314.1\|923105_923522_+\|nucleoside-diphosphate-kinase	unknown	unknown	gnl\|CDD\|179085
NZ_CP011329.1\|WP_000065321.1\|934744_935848_+\|DUF2974-domain-containing-protein	unknown	unknown	gnl\|CDD\|371412
NZ_CP011329.1\|WP_000914664.1\|911640_912771_+\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309
NZ_CP011329.1\|WP_000122194.1\|920296_920638_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_CP011329.1\|WP_000590705.1\|920624_921290_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	pfam09711_csn2_CAS-II-A	gnl\|CDD\|213408
NZ_CP011329.1\|WP_000653357.1\|914272_914929_+\|TIGR01906-family-membrane-protein	unknown	unknown	gnl\|CDD\|226884
NZ_CP011329.1\|WP_000564846.1\|927667_928801_+\|ISAs1-like-element-IS1548-family-transposase	unknown	unknown	gnl\|CDD\|227720
NZ_CP011329.1\|WP_000180005.1\|930234_930894_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NZ_CP011329.1\|WP_001019133.1\|923657_925490_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP011329.1\|WP_000929489.1\|919430_920300_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694

Protein	Function_ID	Function_description	E-value
NZ_CP011329.1\|WP_000621142.1\|930902_931367_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.91796e-19
NZ_CP011329.1\|WP_000159234.1\|910772_911144_+\|YbgA-family-protein	gnl\|CDD\|377982	pfam08349, DUF1722, Protein of unknown function (DUF1722). This domain of unknown function is found in bacteria and archaea and is homologous to the hypothetical protein ybgA from E. coli.	6.08694e-28
NZ_CP011329.1\|WP_000146565.1\|935968_936607_-\|CatB-related-O-acetyltransferase	gnl\|CDD\|100040	cd03349, LbH_XAT, Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. Members of this class of enzymes include Enterococcus faecium streptogramin A acetyltransferase and Pseudomonas aeruginosa chloramphenicol acetyltransferase. They contain repeated copies of a six-residue hexapeptide repeat sequence motif (X-[STAV]-X-[LIV]-[GAED]-X) and adopt a left-handed parallel beta helix (LbH) structure. The active enzyme is a trimer with CoA and substrate binding sites at the interface of two separate LbH subunits. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients.	6.8383e-72
NZ_CP011329.1\|WP_000523795.1\|912774_913512_+\|acyl-ACP-thioesterase	gnl\|CDD\|366738	pfam01643, Acyl-ACP_TE, Acyl-ACP thioesterase. This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid.	3.68196e-111
NZ_CP011329.1\|WP_050881965.1\|915316_919429_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	0
NZ_CP011329.1\|WP_001241816.1\|911168_911549_+\|hypothetical-protein	gnl\|CDD\|131381	TIGR02328, TIGR02328, conserved hypothetical protein. Members of this protein are found in a small number of taxonomically well separated species, yet are strongly conserved, suggesting lateral gene transfer. Members are found in Treponema denticola, Clostridium acetobutylicum, and several of the Firmicutes. The function of this protein is unknown. [Hypothetical proteins, Conserved].	6.45558e-80
NZ_CP011329.1\|WP_000323544.1\|913512_914283_+\|TIGR01457-family-HAD-type-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.19143e-132
NZ_CP011329.1\|WP_000665410.1\|931366_931801_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|234692	PRK00222, PRK00222, peptide-methionine (R)-S-oxide reductase MsrB.	6.40832e-86
NZ_CP011329.1\|WP_000168898.1\|931952_934745_+\|cation-transporting-P-type-ATPase	gnl\|CDD\|223550	COG0474, MgtA, Cation transport ATPase [Inorganic ion transport and metabolism].	0
NZ_CP011329.1\|WP_151383509.1\|929223_930135_+\|leucine-rich-repeat-domain-containing-protein	gnl\|CDD\|380192	NF033188, internalin_H, InlH/InlC2 family class 1 internalin. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin H (InlH), or internalin C2, two class 1 (LPXTG-type) internalins that are closely related, one apparently derived from the other through a recombination event.	6.59746e-11
NZ_CP011329.1\|WP_000438314.1\|923105_923522_+\|nucleoside-diphosphate-kinase	gnl\|CDD\|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	4.64422e-78
NZ_CP011329.1\|WP_000065321.1\|934744_935848_+\|DUF2974-domain-containing-protein	gnl\|CDD\|371412	pfam11187, DUF2974, Protein of unknown function (DUF2974). This bacterial family of proteins has no known function.	1.82724e-105
NZ_CP011329.1\|WP_000914664.1\|911640_912771_+\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0
NZ_CP011329.1\|WP_000122194.1\|920296_920638_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	2.38084e-52
NZ_CP011329.1\|WP_000590705.1\|920624_921290_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213408	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	4.28312e-121
NZ_CP011329.1\|WP_000653357.1\|914272_914929_+\|TIGR01906-family-membrane-protein	gnl\|CDD\|226884	COG4478, COG4478, Predicted membrane protein [Function unknown].	9.75792e-52
NZ_CP011329.1\|WP_000564846.1\|927667_928801_+\|ISAs1-like-element-IS1548-family-transposase	gnl\|CDD\|227720	COG5433, COG5433, Transposase [DNA replication, recombination, and repair].	1.8759e-30
NZ_CP011329.1\|WP_000180005.1\|930234_930894_+\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	5.44358e-33
NZ_CP011329.1\|WP_001019133.1\|923657_925490_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP011329.1\|WP_000929489.1\|919430_920300_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	2.54315e-139

>NZ_CP011329.1|WP_000590705.1|920624_921290_+|type-II-A-CRISPR-associated-protein-Csn2
MIKINFPILDEPLVLSNATILTIEDVSVYSSLVKHFYQYDVDEHLKLFDDKQKSLKATELMLVTDILGYDVNSAPILKLIHGDLENQFNEKPEVKSMVEKLAATITELIAFECLENELDLEYDEIKILELIKALGVKIETQSDTIFEKCFEIIQVYHYLTKKNLLVFVNSGAYLTKDEVIKLCEYINLMQKSVLFLEPRRLYDLPQYVIDKDYFLIGENMV
>NZ_CP011329.1|WP_000122194.1|920296_920638_+|CRISPR-associated-endonuclease-Cas2
MSYRYMRMILMFDMPTETAEERKAYRKFRKFLLSEGFIMHQFSVYSKLLLNNTANNAMIGRLKVNNPKKGNITLLTVTEKQFARMVYLHGERNTSVANSDSRLVFLGDSYDQD
>NZ_CP011329.1|WP_000929489.1|919430_920300_+|type-II-CRISPR-associated-endonuclease-Cas1
MAGWRTVVVNTHSKLSYKNNHLIFKDSYQTEMIHLSEIDILIMETTDIVLSTMLIKRLVDENILVIFCDDKRLPTAMLMPYYARHDSSLQLSRQMSWIEDVKADVWTSIIAQKILNQSFYLGECSFFEKSQSIMNLYHDLEPFDPSNREGHAARIYFNTLFGNDFSREQDNPINAGLDYGYSLLLSMFAREVVKCGCMTQFGLKHANQFNQFNLASDIMEPFRPIVDRIIYENRQSDFVKMKRELFSMFSETYSYNGKEMYLSNIVSDYTKKVIKSLNSDGNGIPEFRI
>NZ_CP011329.1|WP_050881965.1|915316_919429_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MNKPYSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTAADRRLKRTARRRYTRRRNRILYLQEIFAEEMSKVDDSFFHRLEDSFLVEEDKRGSKYPIFATLQEEKDYHEKFSTIYHLRKELADKKEKADLRLIYIALAHIIKFRGHFLIEDDSFDVRNTDISKQYQDFLEIFNTTFENNDLLSQNVDVEAILTDKISKSAKKDRILAQYPNQKSTGIFAEFLKLIVGNQADFKKYFNLEDKTPLQFAKDSYDEDLENLLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKASLPEKYQEIFADSSKDGYAGYIEGKTNQEAFYKYLSKLLTKQEDSENFLEKIKNEDFLRKQRTFDNGSIPHQVHLTELKAIIRRQSEYYPFLKENQDRIEKILTFRIPYYIGPLAREKSDFAWMTRKTDDSIRPWNFEDLVDKEKSAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKNEQGETYFFDSNIKQEIFDGVFKEHRKVSKKKLLDFLAKEYEEFRIVDVIGLDKENKAFNASLGTYHDLEKILDKDFLDNPDNESILEDIVQTLTLFEDREMIKKRLENYKDLFTESQLKKLYRRHYTGWGRLSAKLINGIRDKESQKTILDYLIDDGRSNRNFMQLINDDGLSFKSIISKAQAGSHSDNLKEVVGELAGSPAIKKGILQSLKIVDELVKVMGYEPEQIVVEMARENQTTNQGRRNSRQRYKLLDDGVKNLASDLNGNILKEYPTDNQALQNERLFLYYLQNGRDMYTGEALDIDNLSQYDIDHIIPQAFIKDDSIDNRVLVSSAKNRGKSDDVPSLEIVKDCKVFWKKLLDAKLMSQRKYDNLTKAERGGLTSDDKARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIRKVKIVTLKSNLVSNFRKEFGFYKIREVNNYHHAHDAYLNAVVAKAILTKYPQLEPEFVYGDYPKYNSYKTRKSATEKLFFYSNIMNFFKTKVTLADGTVVVKDDIEVNNDTGEIVWDKKKHFATVRKVLSYPQNNIVKKTEIQTGGFSKESILAHGNSDKLIPRKTKDIYLDPKKYGGFDSPIVAYSVLVVADIKKGKAQKLKTVTELLGITIMERSRFEKNLSAFLESKGYLNIRADKLIILPKYSLFELENGRRRLLASAGELQKGNELALPTQFMKFLYLASRYNESKGKPEEIEKKQEFVNQHVSYFDDILQLINDFSKRVILADANLEKINKLYQDNKENISVDELANNIINLFTFTSLGAPAAFKFFDKIIDRKRYTSTKEVLNSTLIHQSITGLYETRIDLGKLGED
>NZ_CP011329.1|WP_000653357.1|914272_914929_+|TIGR01906-family-membrane-protein
MKDKLLVVLTWIWIISLATLATIYIAWLIYPIEIQFLKLEKVVYLKAETIYYNFNKLMIYLTHPFISDLNMPSFPSSEDGLKHFADVKYLFTLAHGLFVILTFPVIYFLRRGWKQKSIFLYEGFFKIAIMLPIFIVVCAFLLGFDQFFTLFHEVLFPGDSTWQFNPLTDPVIWILPETFFLHCFIIFLLIYETITIILLIIGRKHLKLRKYKNKMQAL
>NZ_CP011329.1|WP_000323544.1|913512_914283_+|TIGR01457-family-HAD-type-hydrolase
MAYKGYLIDLDGTIYKGKSRIPAGERFIERLQEKGIPYMLVTNNTTRTPESVQEMLRGFNVETPLETIYTATMATVDYMNDMNRGKTAYVIGEEGLKKAIADAGYVEDTKNPAYVVVGLDWNVTYDKLATATLAIQNGALFIGTNPDLNIPTERGLLPGAGSLNALLEAATRIKPVFIGKPNAIIMNKALEILNIPRNQAVMVGDNYLTDIMAGINNDIDTLLVTTGFTTVEEVPDLPIQPSYVLASLDEWTFNEG
>NZ_CP011329.1|WP_000523795.1|912774_913512_+|acyl-ACP-thioesterase
MGLLYRETYEVPFYESDTNHYMKLPQLLALALQISAKQSLKLGIGDDIVFKRYGLVWVVTDYIIDIERLPKHAEKIVIETEAKAHNKLLCYRYFYIYGEDGQKIITISSAFVLMDFKTRKIHPVLDDITSIYQSQRIKKVIRGPKYHPIGDSKVKQYHVRYFDLDMNGHVNNSKYLEWMYDVLDLDFLSSHIPKKIDLKYIKEIQYGTDIKSHWYQDGLVTRHDIIGGDAIHAQARIEWQEKKED
>NZ_CP011329.1|WP_000914664.1|911640_912771_+|oxygen-independent-coproporphyrinogen-III-oxidase
MLKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDAYLQALIREFRSYDITELRTLYIGGGTPTSISAVQLDYLLTELSRDLNLNTLEEFTIEANPGDLTVDKIEVLQKSAVNRVSLGVQTFNDKHLKRIGRSHNEAQIYSTIDALKTAGFQNISIDLIYALPGQTMDDVRSNVAKALSLNIPHLSLYSLILEHHTVFMNKMRRGKLHLPTEDLEAEMFEYIISEMERNGFEHYEISNFTKPGFESRHNLMYWDNVEYYGVGAGASGYLDGIRYRNRGPIQHYLKGVSEGNARLSEEVLSKNEMMEEELFLGLRKKEGVSIGKFEQKFGTSFEKRYGQIVQELQSDGLLKENNGFIQMTKKGLFLGDTVAEKFIVE
>NZ_CP011329.1|WP_001241816.1|911168_911549_+|hypothetical-protein
MRLWHQDIIELLPRQQLLGQHRECCALRGNGWGRKHETVDYVFRYSPYRLFAYHQLVMEEMMERGYRVSKEWLIAEYRGMKCPRYDTLNPVDLETPIYPEHNQDYLQECLWNLKAKGIDLPINKIK
>NZ_CP011329.1|WP_000159234.1|910772_911144_+|YbgA-family-protein
MTKEAELLWAKHKYLVLSKSQKIYLDIRQTLKSPNCTVLDVQSLIDQAVLLEESPSQVTNAYMHIWGYFKNKAERQEKEEFLTLLEKYRKTGYQRRKLLAFLKQLLAKYPNSYLQNSSIFEEE
>NZ_CP011329.1|WP_000438314.1|923105_923522_+|nucleoside-diphosphate-kinase
MEQTFFMIKPDGVKRGFIGEVISRIERRGFSIDRLEVRYADADILKRHYAELTDRPFFPTLVDYMTSGPVIIGVISGEEVISTWRTMMGSTNPKDALPGTIRGDFAQAPSPNQATCNIVHGSDSPESATREIAIWFNN
>NZ_CP011329.1|WP_001019133.1|923657_925490_+|elongation-factor-4
MNIEDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRAEVEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGEVDAPLQALIFDSVYDAYRGVILQVRIVNGMVKPGDKIQMMSNGKTFDVTEVGIFTPKAVGRDFLATGDVGYIAASIKTVADTRVGDTITLANNPAIEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGEMLEVSNPSEFPDPTRVDSIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYEISEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDDKK
>NZ_CP011329.1|WP_000564846.1|927667_928801_+|ISAs1-like-element-IS1548-family-transposase
MIDFIISIDDCAVELDSRQSWKIRYPLSTILFLVFVCQLAGIETWKEMEDFIEMNEPLFATYVDLSEGCPSHDTLERVISLVNSDRLKELKVQFEQSLTSLDAVHQLISVDGKTIRGNRGKNQKPVHIVTAYDGGHHLSLGQVAVEEKSNEIVAIPQLLRTIDIRKSIVTIDAMGTQTAIVDTIIKGKADYCLAVKGNQETLYDDIALYFSDVNLLEELQENAQYYQTVEKSRGQIEVREYWVSSDIKWLCQNHPKWHKLRGIGMTRNTIDKDGQLSQENRYFIFSFKPDVLTFANCVRGHWQIESMHWLLDVVYHEDHHQTLDKRAAFNLNLIRKMCLYFLKVMVFPKKDLSYRRKQRYISVHLEDYLVQLFGERG
>NZ_CP011329.1|WP_151383509.1|929223_930135_+|leucine-rich-repeat-domain-containing-protein
MEKEAKQIIDLKRNLFKIDVRAQKDEEKVFMRTACLTPLSNLTKLQELYLDHNNVKNLSALSCKKDLKVLDLSNNKSADLSTLKTTSLETLLLNETNTSNLSFLKQNPKVSNLTINNAKLASLDGIEESDEIVKVEAEGNQIKSLVLKNKQGSLKFLNVTNNQLTSLEGVNNYTSLETLSVSKNKLESLDIKTPNKTVTNLDFSHNNVPTSQLKLNEKNIPEAVAKNFPAVVEGSMVGNGSLAEKAAMASKEDKQVSDNTNHQKNTEKSAQANADSKKENPKTHDEHHDHEETDHAHVGHHHH
>NZ_CP011329.1|WP_000180005.1|930234_930894_+|HD-domain-containing-protein
MTMVKREDVILNATENMVHHKLKNDPSGHDWFHIVRVRNLAVELAHKEGANTFICQMAALLHDIIDDKICQDSKQASYELTQWLYSQDLAIAEVEHILDILENISFKAGTGLTMKTLEGQIVQDADRLDAMGAIGIARTMAYSGSKGRLIHDPNLKPRENLTLEEYRNGQDTAIIHFYEKLLKLKDLMNTKQGKMLAQKRHDFLELYLAEFYAEWNGKR
>NZ_CP011329.1|WP_000621142.1|930902_931367_+|GNAT-family-N-acetyltransferase
MIRRAKEKDLPDIAELLKQILMLHHEVRPDIFHTRGSKFSKEQLKEMLIDESKPIFVYESDEGKVVAHLFLQLQEKRDLPRKSFKTLYIDDLCIDEEVRGQQIGQKLMDFARQYAKKHGCYNITLNVWNDNQRAVSFYEKLGFKPQQTQMEEIL
>NZ_CP011329.1|WP_000665410.1|931366_931801_+|peptide-methionine-(R)-S-oxide-reductase-MsrB
MKETQEELRQRIGHTAYQVTQNSATEHAFTGKYDDFFEEGIYVDIVSGEVLFSSLDKFQSGCGWPAFSKPIENRMVTNHQDHSHGMHRIEVRSRQADSHLGHVFNDGPVDAGGLRYCINSAALDFIPYDQMAKRGYGDYLSLFD
>NZ_CP011329.1|WP_000168898.1|931952_934745_+|cation-transporting-P-type-ATPase
MASTNNVSDTNTRFAKEELEEVFEELGTTQGGLSDEEVAVRQKKYGLNLLSEVKQESIILLFLKNFTSLMAILLWVGGFVAIVSNSLELGLAIWMVNVINGIFSFIQEYRASQATQALEKMLPSYSRVLRKGSEEKILSEQLVPGDIVLIEEGDRISADGRLIKTTDLQVNQSALTGESNPIYKDSNVENDQSKTLIECDNMVFAGTTVSSGSATMVVTAIGMQTQFGQIADLTQGMKSEKSPLQRELDRLTKQISIISITVGIIFFLAATFFVKEPVSKSFIFALGMIVAFIPEGLLPTVTLSLAMAVQRMAKEHALVKKLSSVETLGATSVICSDKTGTLTQNEMTVNHLWQNGKSYQVTGLGYAPEGQILFEGDNICFGNSDRGDLEKLIRFAHLCSNAQVLPPNDDRSTYTVLGDPTEACLNVLLEKSGINIQENRKFAPRLKELPFDSVRKRMTTIHSLGGDEKDKKISITKGAPKEILDLSDYVLSDGKVIPLNKEERNKIQLANDTFAKDGLRVLAVSYCDIEGFSKEQWTQENLEQHMVFIGLIAMSDPPREGVREAIDKCHAASIRIIMVTGDYGLTALSIAKNIGIIRNDDAKVISGLELSEMTDSQLKKELSGEVVFARVAPEQKYRVVTILQEMGEVVAVTGDGVNDAPALKKSDIGVAMGVTGTDVAKESADMILTDDHFASIVHAVEEGRAVYQNIKKFLTYIFNSNTPEAVPSAFFLFSKGFIPLPLTVMQILAVDLGTDMLPALGLGVEPPETDVMNRPPRRLTDRLLDKGLLIKSFLWYGTIESVLAMGGFFWAHYLRYGNFTFFVANGIPYREATTMTLGAIIFSQIGMVMNSRTSYQSIKALSIFGNKLINFGIIMEILAFLVLVYVPLFHNLFNTASLGLSHWLYLISCPFIMIGLDEVRKLFSSRKNKR
>NZ_CP011329.1|WP_000065321.1|934744_935848_+|DUF2974-domain-containing-protein
MSNIITYLKNNSNLTFDELALNDVDILCLNEFGYISFEKLINTTEMKSVLVCELYHEYLQTMAKSYSFMFTSQRHDLCQLMMTSKRFKNLTLSYYRAEISLEFEKQFAAMVFTIPNINYHQVVFRGTDANLIGWKEDFKLTYMREISAHRSAIKYLNTILPYFDKVVLSGHSKGGNLALYAAMFTKPDLKAKIDLIWLIDSPGLQKTLLPTTEYKTTKQKCIRLLPEESIVGMMLYSDIEPLIISSNARGILQHDVTTWEIQEPAILKTGTGLSLKSICFEKTFQQWMAELKSQERKLFFDLLFDSFLSSGVSSLDDFNLASRAKMMKAFHSFRELDDDKKRLFNKSLKLLVTIFWGAYHDNSRETK
>NZ_CP011329.1|WP_000146565.1|935968_936607_-|CatB-related-O-acetyltransferase
MASILKKHLEKRLELKNDPMRTDMSTGASYPKYGFSVGKYTYGYQQFFYEGVNLKEIGAFCSIAQNVTITGLNHPTDHITTNPFIYYKSRGFINEDRADLIDEKKNGKVIIGNDVWIGTNVTILPSVTIGNGAIIGAGSVITKDIPDYAVVAGTPAKIIKYRFSEEEITLLNASQWWNWSDEAIKEHISEFSDKKEFFNTLKSISENKNHKL

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Crispr_ID: NZ_CP011329_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011329_3

2037671-2038131

Orphan

Consensus_repeat	Method
CNTCTGGNTTANCNTCTGGNTTANCNTCT	CRT

7 spacers

The CRISPR arrays of NZ_CP011329_3

>merge|NZ_CP011329|3|2037671-2038131|CRT
CCTCTGGTTTAGCTTCTAGCTTAGCCTCTGGTTTAGCTTCTGACTTAGCCTCTGGTTTAGCTTCTGGCTTAGCCTCTGGTTTAACGTCTGGTTTAGCTTCTGGCTTAACGTCTGGCTTAGCTTCTGGTTTGGCCTCTGGCTTAGCTTCTGGCTTAGCTTCTGGCTTAGCTTCTGGTTTGGCCTCTGGCTTAACGTCTGGTTTAGCTTCTGGCTTAACGTCTGGTTTAACGTCTGGCTTATCCTCTGGTTTGGCCTCTGGCTTAACGTCTGGTTTAACGTCTGGTTTAACGTCTGGCTTAGCTTCTGGCTTAACGTCTGGTTTGGCCTTTGGTTTAACGTCTGGCTTAGCTTCTGGTTTAACGTCTGGCTTAGCTTCTGGTTTAACGTCTGGCTTAGCTTCTGGTTTAACGTCTGGCTTAGCTTCTGGCTTAACGTCTGGTTTGGCCTCTGGCTTAACGTCT

>NZ_CP011329|3|3|2037671-2038131|CRT
CCTCTGGTTTAGCTTCTAGCTTAGCCTCT	GGTTTAGCTTCTGACTTAGCCTCTGGTTTAGCTTCTGGCTTAG
CCTCTGGTTTAACGTCTGGTTTAGCTTCT	GGCTTAACGTCTGGCTTAGCTTCTGGTTTGG
CCTCTGGCTTAGCTTCTGGCTTAGCTTCT	GGCTTAGCTTCTGGTTTGG
CCTCTGGCTTAACGTCTGGTTTAGCTTCT	GGCTTAACGTCTGGTTTAACGTCTGGCTTATCCTCTGGTTTGG
CCTCTGGCTTAACGTCTGGTTTAACGTCT	GGTTTAACGTCTGGCTTAGCTTCTGGCTTAACGTCTGGTTTGGCCTTTGGTTTAA
CGTCTGGCTTAGCTTCTGGTTTAACGTCT	GGCTTAGCTTCTGGTTTAA
CGTCTGGCTTAGCTTCTGGTTTAACGTCT	GGCTTAGCTTCTGGCTTAA
CGTCTGGTTTGGCCTCTGGCTTAACGTCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011329.1\|WP_000730417.1\|2026824_2028213_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP011329.1\|WP_000161338.1\|2026141_2026828_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP011329.1\|WP_000410681.1\|2020182_2020875_-\|AzlC-family-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224215
NZ_CP011329.1\|WP_000764803.1\|2040090_2042412_-\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223815
NZ_CP011329.1\|WP_050882017.1\|2046452_2047124_-\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|234784
NZ_CP011329.1\|WP_000074744.1\|2031878_2033126_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340929
NZ_CP011329.1\|WP_000459236.1\|2043364_2045005_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226987
NZ_CP011329.1\|WP_001182060.1\|2048376_2049156_-\|uridine-phosphorylase	unknown	unknown	gnl\|CDD\|350167
NZ_CP011329.1\|WP_000903268.1\|2028305_2028914_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011329.1\|WP_000010476.1\|2042455_2043340_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP011329.1\|WP_000145178.1\|2029000_2031502_-\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_CP011329.1\|WP_000953624.1\|2033168_2034014_-\|patatin-family-protein	unknown	unknown	gnl\|CDD\|132847
NZ_CP011329.1\|WP_001125581.1\|2049313_2050051_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP011329.1\|WP_000077187.1\|2045174_2046386_-\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
NZ_CP011329.1\|WP_000497678.1\|2039680_2039854_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|223762
NZ_CP011329.1\|WP_000409544.1\|2035479_2036685_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133037
NZ_CP011329.1\|WP_000222146.1\|2034218_2035415_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133037
NZ_CP011329.1\|WP_000887149.1\|2036731_2037271_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_CP011329.1\|WP_000057521.1\|2039889_2040042_-\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_CP011329.1\|WP_001159687.1\|2047153_2048356_-\|NupC/NupG-family-nucleoside-CNT-transporter	unknown	unknown	gnl\|CDD\|224883

Protein	Function_ID	Function_description	E-value
NZ_CP011329.1\|WP_000730417.1\|2026824_2028213_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	8.25321e-46
NZ_CP011329.1\|WP_000161338.1\|2026141_2026828_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.15526e-62
NZ_CP011329.1\|WP_000410681.1\|2020182_2020875_-\|AzlC-family-ABC-transporter-permease	gnl\|CDD\|224215	COG1296, AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism].	2.21364e-51
NZ_CP011329.1\|WP_000764803.1\|2040090_2042412_-\|penicillin-binding-protein	gnl\|CDD\|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	0
NZ_CP011329.1\|WP_050882017.1\|2046452_2047124_-\|deoxyribose-phosphate-aldolase	gnl\|CDD\|234784	PRK00507, PRK00507, deoxyribose-phosphate aldolase; Provisional.	5.97399e-109
NZ_CP011329.1\|WP_000074744.1\|2031878_2033126_+\|MFS-transporter	gnl\|CDD\|340929	cd17371, MFS_MucK, Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.13125e-70
NZ_CP011329.1\|WP_000459236.1\|2043364_2045005_-\|hypothetical-protein	gnl\|CDD\|226987	COG4640, COG4640, Predicted membrane protein [Function unknown].	2.43912e-08
NZ_CP011329.1\|WP_001182060.1\|2048376_2049156_-\|uridine-phosphorylase	gnl\|CDD\|350167	cd17767, UP_EcUdp-like, uridine phosphorylases similar to Escherichia coli Udp and related phosphorylases. Uridine phosphorylase (UP) is specific for pyrimidines, and is involved in pyrimidine salvage and in the maintenance of uridine homeostasis. In addition to E. coli Udp, this subfamily includes Shewanella oneidensis MR-1 UP and Plasmodium falciparum purine nucleoside phosphorylase (PfPNP). PfPNP is an outlier in terms of genetic distance from the other families of PNPs. PfPNP is catalytically active for inosine and guanosine, and in addition, has a weak UP activity. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	4.65794e-137
NZ_CP011329.1\|WP_000077187.1\|2045174_2046386_-\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
NZ_CP011329.1\|WP_000010476.1\|2042455_2043340_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	7.14066e-85
NZ_CP011329.1\|WP_000145178.1\|2029000_2031502_-\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_CP011329.1\|WP_000953624.1\|2033168_2034014_-\|patatin-family-protein	gnl\|CDD\|132847	cd07208, Pat_hypo_Ecoli_yjju_like, Hypothetical patatin similar to yjju protein of Escherichia coli. Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	3.0357e-122
NZ_CP011329.1\|WP_001125581.1\|2049313_2050051_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	1.61492e-32
NZ_CP011329.1\|WP_000497678.1\|2039680_2039854_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|223762	COG0690, SecE, Preprotein translocase subunit SecE [Intracellular trafficking and secretion].	5.81702e-09
NZ_CP011329.1\|WP_000409544.1\|2035479_2036685_+\|hypothetical-protein	gnl\|CDD\|133037	cd04194, GT8_A4GalT_like, A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.	1.96805e-72
NZ_CP011329.1\|WP_000222146.1\|2034218_2035415_+\|hypothetical-protein	gnl\|CDD\|133037	cd04194, GT8_A4GalT_like, A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.	4.07197e-67
NZ_CP011329.1\|WP_000887149.1\|2036731_2037271_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	3.00072e-83
NZ_CP011329.1\|WP_000057521.1\|2039889_2040042_-\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	2.53308e-18
NZ_CP011329.1\|WP_001159687.1\|2047153_2048356_-\|NupC/NupG-family-nucleoside-CNT-transporter	gnl\|CDD\|224883	COG1972, NupC, Nucleoside permease [Nucleotide transport and metabolism].	1.32155e-154

>NZ_CP011329.1|WP_000887149.1|2036731_2037271_-|transcription-termination/antitermination-protein-NusG
MLDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIPTQTVNVEKNGKTKEIEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPTPLLEEEIRSILISMGQTVDVFDTNIKEGDVVQIIDGAFIGQEGRVVEIENNKVKLMINMFGSETQAELELYQVAEL
>NZ_CP011329.1|WP_000409544.1|2035479_2036685_+|hypothetical-protein
MEKAVALAVDSNYLDKALVTIKSICVYNRNITFYLFNQDTPVEWVRNINRKLEPLGSKLINVKIYNYDIAHLTTFLTVSTWFRLFLADYIPSSRVLYLDSDIIVNTNLDYLFELDFKGYYLAAVKDPHKNEEGGFNAGMLLANLELWREDGLTKTLLKTAEELHRVVKTGDQSILNIVCHNRWLSLNKTWNFQTYDVVSRYNHRSYLYLNIENRTPNIIHFLTSDKPWNENSVARFRELWWYYFQLDFCQLTGKQRKVISYEKSMELLSVSDIHLFTLTSSDNLEHIESLICRCPTVQFHIGAYTTVSNKLSKLEQYPNVLVYPELIEARIEKLITLATAYLDINHGPEVGNILQRVHLKQKPIYSFNNTSHQENITKHIVNHNSIDNMVVLINELNLNQL
>NZ_CP011329.1|WP_000222146.1|2034218_2035415_+|hypothetical-protein
MTYQKTVVLAGDYSYIRQIETTLKSLCVYHENLSIFIFNQDIPQEWFLAMKDRVGQTGNQIQDVKLFHDHLSPKWENKKLNHINYMTYARYFIPQYISADTVLYLDSDLVVTTNLDNLFQISLDNAYLAAVPALFGLGYGFNAGVMVINNQRWRQENMTIKLIEKNQKEIENANEGDQTILNRMFENQVIYLDDTYNFQIGFDMGAAIDGHKFIFDIPITPLPKIIHYISGIKPWQTLSNMRLREVWWHYNLLEWSSIISSKKVFGLDHPIKTQNYRLNFLIVTTSDCIPSISELVTALPDCLFHIAAPTVMSDILISLLAFENIRLHKTYTPPIIDKLLAEADIYLDINVFGKMEGILQKMSQSEKPILTTRECNSQLVPETVFASIDDLINYLQSI
>NZ_CP011329.1|WP_000953624.1|2033168_2034014_-|patatin-family-protein
MLSVGLVLEGGGMRGLYTAGVLDAFLDAGIKIDGIVSVSAGALFGVNFVSRQRERALRYNKKYLSHPKYMSLRSWFRTGNFVNKDFTYYEVPMKLDVFDDEAFKKSSIDFYVVATEMTSGKPEYFKIDSVFEQMEILRASSALPVVSKMVDWQGKKYLDGGLSDSIPVDFARGLGFDKLIVVMTRPLNYQKKPSSGRLYKTLYRKYPNFVKTASNRYQQYNNSLEKVMSLEKTGDLFAIRPSKSLVIGRLEKNPDKLDSIYQLGMKDAKSVMPELNSYLMK
>NZ_CP011329.1|WP_000074744.1|2031878_2033126_+|MFS-transporter
MSPLNINKNNWRALIAAIVASGTDDLNIMFLAFSMSTIITDLHLSAAQAGWIGTITNLGMLVGGLIFGLLADRYNKFKVFKWTILIFSIATGLVFFTTNLSYLYIMRFIAGIGVGGEYGIAIAIMAGIVPTNKMGRISSLNGIAGQVGSISSALLAGWLAPALGWRGLFLFGLLPIVLVLWMQFAVDDKDILDQYNTDADDEPLDISIKALFDTPVLATQSLALMVMTTVQIAGYFGMMNWLPTIIQTNLNVSVKNSSLWMIATILGMCLGMLVFGQLLDKFGPRLVYGCFLLSSAICVYLFQFATTMPSMIIGGAVVGFFVNGMFAGYGAMITRLYPHHIRSTANNLILNVGRAIGGFSSVIIGMILDVSNVSMVMLFLASLYIVSFLSMLSIKQLKRQKYHTNLTQLDVKPTD
>NZ_CP011329.1|WP_000145178.1|2029000_2031502_-|leucine--tRNA-ligase
MTFYNHKEIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVEELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKDMQRNWIGKSTGANVTFKVKDTDKDFTVFTTRPDTLFGATYAVLAPEHALVDAITTADQAEAVAEYKRQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEIPVWIADYVLASYGTGAIMAVPAHDERDWEFAKQFNLDIIPVLEGGNVEEAAFTEDGLHINSDFLDGLDKAAAIAKMVEWLEAEGVGNEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLFNQGMILGTSYRDSRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITTKEITEENSGALDKVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDKLFSDYAKGFVQLIAPFAPHLGEELWQVLTASGQSISYVPWPSYDESKLVENEIEIVVQIKGKVKAKLVVAKDLSREELQDLALANEKVQAEIAGKDIIKVIAVPNKLVNIVVK
>NZ_CP011329.1|WP_000903268.1|2028305_2028914_+|hypothetical-protein
MLHSKKIHSLSLIAVLSLATYTSLQPNHVTAEQSQKTSTVHMSQKTIEHKLKVADKEAAPLYAKIDHIQRHIEVKKAKDLKVIELYINKDINQLEKQNKRLLTKFYTSIDNQTWDSTSEVKKLIDKTNLSTNEKDRLKLYFEQRAYLETRLNDRYQKFDNSIENQNKELKILTSKIEKIYQKHGITKEVLKTYYAKKTVRAD
>NZ_CP011329.1|WP_000730417.1|2026824_2028213_+|HAMP-domain-containing-histidine-kinase
MKKKSLISNLILINSITLFLGFYLIYFSVNYVIKDYVHQMTRNSMQANFTILDSIYNNKKIPDENMVNQDSIFVWSYYAIFDQHYRMKYGTDNHKKESHDIIRYLTQKRLWQISKEKDGMFVTIKKKTYYVMTKDYSGILVDGSIKKVPKAQSQLFHVINFSDITYTQHLITKINHFLIVILVLTYIPMLFIMRKTFTGIRESIQSVQTYISSLWKNQGNHQSSQKEIVFSDFDPLLLESQEMANRIYQAEESQRNFFQNASHELRTPLMSIQGYTEGVQEGIIDAELAHSVILQESKKMKQLVDDIILLSKLDSNLSDQKDEFSLNELLNSIIAYFKPLANKQKISITYRPDKHEKLLKGNEELIQRAINNILSNALRYAVSHIEISYTNQKLTISNDGPAISKEDLPYIFDRFYKGHGGQTGIGLAMTKEIIKQHHGNIIAESDSTSTTFTIYFNCHKIA
>NZ_CP011329.1|WP_000161338.1|2026141_2026828_+|response-regulator-transcription-factor
MTKIIYFADDEKNIRDLVVPFLEHDGFTVRAFETGDLLLEAYKNQKPDLVILDIMMPGTNGLDVMKSIRQYDNIPIIMLTARDSDVDFITAFNLGTDDYFTKPFSPIKLSLHVKALFKRLDEKAIKNDTQYQFLDLTLDTEKRIALLSNEEMPLTKTEFDFLLVLIEKPETAFSRETLLNRIWGFDDIESRAVDDTIKRLRKKFKQYHSQVSIKTVWGYGFKLIKEDK
>NZ_CP011329.1|WP_000410681.1|2020182_2020875_-|AzlC-family-ABC-transporter-permease
MEKGFKEGVKDALPTALGYISIGLAFGIVASASDLSAIEVGLMSALVYGGSAQFAMCALLLAKADLMTITMTVFLVNLRNMLMSLHATTIFKSAHLMNQLAIGTLITDESYGVLLGEALHHKVVSPSWMHGNNVMSYLTWVISTIIGTLLGSTIPNPEMFGLDFALVAMFIGLFVFQLFGMLSDGKRLVVYVLASVGLSYFLLATFLSGALSVLLATVVGCSVGVVLDDK
>NZ_CP011329.1|WP_000497678.1|2039680_2039854_-|preprotein-translocase-subunit-SecE
MFVKGIFQVLRDTTWPNRKQRWKDFISILEYTVFFTIVIYIFDKLLAAGVMDLINRF
>NZ_CP011329.1|WP_000057521.1|2039889_2040042_-|50S-ribosomal-protein-L33
MAQKKASLACTECGSRNYSIGVSSTPKPTRLEVNKFCKYCKKYTIHKETR
>NZ_CP011329.1|WP_000764803.1|2040090_2042412_-|penicillin-binding-protein
MKLFDKFIDLFRVDEDNDEMTRKNEQETREETSNLDGEEVYDIDDITRPSKSQYQRGIRHQKENAKSRPEWLQKVDRYLPSPKNPIRRFWRRYRIGKLLFIALMAFILIFGSYLFYLSKTATVSDLQSALKTTTTIYDKNKEYAGKLSGQKGTYVELNAISDHLKNAVIATEDRTFYENNGVNFKRFFLAVATLGKFGGGSTITQQLAKNAYLSQDQTIKRKAREFFLALELTKKYSKAEILTMYLNNSYFGNGVWGVEDASRKYFGTSAANLTVDEAATLAGMLKGPEVYNPYYSVENATNRRDTVLAAMVDAGKLTKSQAKEAASIGMKNRLADTYAGKINDYRYPSYFDAVVNEAIDTYGISEKDIVNNGYKIYTALDQNYQSGMQKTFDDTSLFPVSDYDGQSAQGASVALDPKTGGVRGLVGRVQSTKDAQFRSFNYATQSKRSPASTIKPLVVYSPAIASGWSIDKELPNKVQDFHGYKPSNYGGIETESIPMYQALANSYNIPAVYTLDKLGINKAFTYGRKFGLNMSSANKELGVALGGSVTTNPLEMAQAYSTFANDGIMHRAHLITRIETANGKLVKQFTDKPKRVISRSVASKMTSMMLGTFSNGTAINANVYGYTMAGKTGTTETDFNPNLSGDQWVVGYTPDVVISQWVGFKNTDKHHYLTDSSAGTASNIFSTQASYILPYTKGSSFTHIENAYFQNGIGSVYNAQDASNTTNQESRSIINDLKDSASKAAQDISRAVEDSNFQEKVKDAWNSLKDYFR
>NZ_CP011329.1|WP_000010476.1|2042455_2043340_+|RluA-family-pseudouridine-synthase
MSFSLKIRNPYGEHTVKELLEDYFLIPRKIRHFLRVKKHVLINNEFINWQTVVQENDTITLIFDDEDYPTKKIPLGRAELIDCLYEDEHLIIVNKPEGMKTHGNQPNEIALLNHVSAYSGQTCYVVHRLDMETSGAVLFAKNPFILPLINQRLERKEIWREYWALVEGKFSPKHQVLRDKIGRNRHDRRKRIIDSKNGQHAMTIIDVLKYIQNSSLIKCRLETGRTHQIRVHLSHHGHPLIGDPLYNPSSNNERLMLHAHRLTLSHPLTCETISVEAPSSTFEKILNNYKKGVG
>NZ_CP011329.1|WP_000459236.1|2043364_2045005_-|hypothetical-protein
MFDFFKKKVVKVCLVIFGIVLVSLLSLGFFYFSKGQVLSRFVAARSRTSGQAFDNIKEYMVWSDTGESITNDEANYANFEPLSKSEARKLGQEIKEGNKNDSMYLKRVGSRLGIFPDYRIANKPMSLTLKTNVPKLDVLLNQKKVATSNSDHFSVTVERLPRTHYTASLEGTSDGKEIKLKKDYDGKNQTIDLSVAFKSFTVTSNLMDGNLYFGDNRIAKLKDGSHSVENYPVTDGSKAYIKKVFNDGEITSHKQKLISIADNQTIKLDVDGLLNEKEAGQKLITAFNQLILYVSTGQDPQTLGTVFEKGAENDFYKGLKESIKAKFVTDNRKASHFTIPNIVLNKMTQVGKESYQVNFAADYDFNYDKSTDPDKKTYGHIIQNLTGNFIMKKSGNSYLISNDGKKDITVAKETNKVKADPVSIFPENLVGSWKGEVEDGTVTMTFDKDGKVTQKKVYKDSKSKESNHSAKVTKLEDKGNGLYLYQYESGTDTTTFVTGGIGGLKVKYAYGIKIEGNKIIPVIWQTSSDGEFDYHKPLLSKPLTKQ
>NZ_CP011329.1|WP_000077187.1|2045174_2046386_-|phosphopentomutase
MSQFDRIHLVVLDSVGIGAAPDANDFVNAGVPDGASDTLGHISKTVGLAVPNMAKIGLGNIPRPQALKTVPAEENPSGYATKLQEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEDIITKIEDFSGRKVIREANKPYSGTAVIDDFGPRQMETGELIIYTSADPVLQIAAHEDIIPLEELYRICEYARSITMERPALLGRIIARPYVGEPGNFTRTANRHDYAVSPFEDTVLNKLDQAGIDTYAVGKINDIFNGSGINHDMGHNKSNSHGIDTLIKTMGLSEFEKGFSFTNLVDFDALYGHRRDPHGYRDCLHEFDERLPEIISAMRDKDLLLITADHGNDPTYAGTDHTREYIPLLAYSPSFTGNGLIPVGHFADISATVADNFGVDTAMIGESFLQDLV
>NZ_CP011329.1|WP_050882017.1|2046452_2047124_-|deoxyribose-phosphate-aldolase
MEVKDILKTVDHTLLATTATWPEIQTILDDAMAYETASACIPASYVKKAAEYVSGKLAICTVIGFPNGYSTTAAKVFECQDAIKNGADEIDMVINLTDVKNGDFDTVEEEIRQIKAAYQDHILKVIVETCQLTKEELIELCGVVTRSGADFIKTSTGFSTAGATFEDVEVMAKYVGEGVKIKAAGGISSLEDAEKFIALGASRLGTSRIIKIVKNQKVEEGTY
>NZ_CP011329.1|WP_001159687.1|2047153_2048356_-|NupC/NupG-family-nucleoside-CNT-transporter
MQFIYSIIGILLVLGIVYAISFNRKSVSLSLIGKALIVQFIIALILVRIPLGQQVVSVVSTGVTKVINCGQAGLNFVFGSLADSGAKTGFIFAIQTLGNIVFLSALVSLLYYVGILGFVVKWIGKGVGKIMKSSEVESFVAVANMFLGQTDSPILVSKYLGRMTDSEIMVVLVSGMGSMSVSILGGYIALGIPMEYLLIASTMVPIGSILIAKILLPQTEPVQKIDDIKMDNKGNNANVIDAIAEGASTGAQMAFSIGASLIAFVGLVSLINMMLSGLGIRLEQIFSYVFAPFGFLMGFDHKNILLEGNLLGSKLILNEFVSFQQLGDLIKSLDYRTALVATISLCGFANLSSLGICVSGIAVLCPEKRGTLARLVFRAMIGGIAVSMLSAFIVGIVTLF
>NZ_CP011329.1|WP_001182060.1|2048376_2049156_-|uridine-phosphorylase
MQNYSGEVGLQYHLQIRPGDVGRYVIMPGDPKRCAKIAEHFDNAVLVADSREYVTYTGTLNGEKVSVTSTGIGGPSASIAMEELKLCGADTFIRVGTCGGIDLDVKGGDIVIATGAIRMEGTSKEYAPIEFPAVADLEVTNALVNAAKKLGYTSHAGVVQCKDAFYGQHEPERMPVSYELLNKWEAWKRLGTKASEMESAALFVAASHLGVRCGSDFLVVGNQERNALGMDNPMAHDTEAAIQVAVEALRTLIENDKSQ
>NZ_CP011329.1|WP_001125581.1|2049313_2050051_+|GntR-family-transcriptional-regulator
MPKNELNNKLNKLKHVQVYNKIFNMIQDGTYSPGMQLPSEPELAGQLNVSRATLRKSLALLQEDHLVKNIRGKGNFIRENSSNLSENGYENRQHPIKTCLTSKITEVELEFRVEVPAEAITASLKQETPVVVIADRWYHTDDGPLAYTLSFIPIELISDAEISLHDTKQLLNFIEEGIYQEGISSHSQSHLGYATSGNFSATKYTLSDHGQFILIQETIFKQEKILMCNKHYVPIEHFELSITSH

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP011329_2	2.10\|922021\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	922021-922050	30	NZ_CP011329.1	1143966-1143995	0	1.0
NZ_CP011329_3	3.3\|2037832\|19\|NZ_CP011329\|CRT	2037832-2037850	19	NZ_CP011329.1	2038120-2038138	2	0.895
NZ_CP011329_3	3.7\|2038084\|19\|NZ_CP011329\|CRT	2038084-2038102	19	NZ_CP011329.1	2038144-2038162	2	0.895

1. spacer 2.10|922021|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to position: 1143966-1143995, mismatch: 0, identity: 1.0

agtactgcactaggaattgtagagatcaaa	CRISPR spacer
agtactgcactaggaattgtagagatcaaa	Protospacer
******************************

2. spacer 3.3|2037832|19|NZ_CP011329|CRT matches to position: 2038120-2038138, mismatch: 2, identity: 0.895

ggcttagcttctggtttgg	CRISPR spacer
ggcttaacgtctggtttgg	Protospacer
******.* **********

3. spacer 3.7|2038084|19|NZ_CP011329|CRT matches to position: 2038144-2038162, mismatch: 2, identity: 0.895

ggcttagcttctggcttaa	CRISPR spacer
ggtttggcttctggcttaa	Protospacer
**.**.*************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP011329_1	1.1\|625417\|47\|NZ_CP011329\|CRT	625417-625463	47	MK448726	Streptococcus phage Javan29, complete genome	26537-26583	0	1.0
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448726	Streptococcus phage Javan29, complete genome	26603-26649	0	1.0
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448726	Streptococcus phage Javan29, complete genome	26669-26715	0	1.0
NZ_CP011329_2	2.1\|921427\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921427-921456	30	MK448829	Streptococcus phage Javan7, complete genome	16033-16062	0	1.0
NZ_CP011329_2	2.1\|921427\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921427-921456	30	MK448736	Streptococcus phage Javan35, complete genome	16516-16545	0	1.0
NZ_CP011329_2	2.1\|921427\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921427-921456	30	MK448781	Streptococcus phage Javan5, complete genome	18538-18567	0	1.0
NZ_CP011329_2	2.1\|921427\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921427-921456	30	MH853355	Streptococcus phage LF1, complete genome	6890-6919	0	1.0
NZ_CP011329_2	2.1\|921427\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921427-921456	30	MK448911	Streptococcus phage Javan34, complete genome	16516-16545	0	1.0
NZ_CP011329_2	2.1\|921427\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921427-921456	30	MK448837	Streptococcus phage Javan10, complete genome	14562-14591	0	1.0
NZ_CP011329_2	2.1\|921427\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921427-921456	30	MK448742	Streptococcus phage Javan37, complete genome	16352-16381	0	1.0
NZ_CP011329_2	2.1\|921427\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921427-921456	30	MH853358	Streptococcus phage LF4, complete genome	6890-6919	0	1.0
NZ_CP011329_2	2.1\|921427\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921427-921456	30	MK448916	Streptococcus phage Javan36, complete genome	16516-16545	0	1.0
NZ_CP011329_2	2.4\|921625\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921625-921654	30	MH853356	Streptococcus phage LF2, partial genome	8933-8962	0	1.0
NZ_CP011329_2	2.4\|921625\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921625-921654	30	MK448971	Streptococcus phage Javan52, complete genome	11470-11499	0	1.0
NZ_CP011329_2	2.7\|921823\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921823-921852	30	MK448932	Streptococcus phage Javan42, complete genome	9396-9425	0	1.0
NZ_CP011329_2	2.7\|921823\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921823-921852	30	MK448669	Streptococcus phage Javan11, complete genome	9396-9425	0	1.0
NZ_CP011329_2	2.8\|921889\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921889-921918	30	MK448956	Streptococcus phage Javan48, complete genome	33709-33738	0	1.0
NZ_CP011329_2	2.8\|921889\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921889-921918	30	MK448742	Streptococcus phage Javan37, complete genome	30403-30432	0	1.0
NZ_CP011329_2	2.8\|921889\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921889-921918	30	JX409894	Streptococcus phage LYGO9, complete genome	13405-13434	0	1.0
NZ_CP011329_2	2.8\|921889\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921889-921918	30	JX409895	Streptococcus phage JX01, complete genome	25252-25281	0	1.0
NZ_CP011329_2	2.9\|921955\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921955-921984	30	MK448837	Streptococcus phage Javan10, complete genome	30521-30550	0	1.0
NZ_CP011329_2	2.11\|922087\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	922087-922116	30	MK448971	Streptococcus phage Javan52, complete genome	15906-15935	0	1.0
NZ_CP011329_2	2.11\|922087\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	922087-922116	30	MK448829	Streptococcus phage Javan7, complete genome	12452-12481	0	1.0
NZ_CP011329_2	2.11\|922087\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	922087-922116	30	MH853355	Streptococcus phage LF1, complete genome	3309-3338	0	1.0
NZ_CP011329_2	2.11\|922087\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	922087-922116	30	MH853356	Streptococcus phage LF2, partial genome	3481-3510	0	1.0
NZ_CP011329_2	2.11\|922087\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	922087-922116	30	MK448837	Streptococcus phage Javan10, complete genome	10978-11007	0	1.0
NZ_CP011329_2	2.11\|922087\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	922087-922116	30	MH853358	Streptococcus phage LF4, complete genome	3309-3338	0	1.0
NZ_CP011329_1	1.1\|625417\|47\|NZ_CP011329\|CRT	625417-625463	47	MK448928	Streptococcus phage Javan40, complete genome	26645-26691	1	0.979
NZ_CP011329_1	1.1\|625417\|47\|NZ_CP011329\|CRT	625417-625463	47	MK448728	Streptococcus phage Javan3, complete genome	26649-26695	1	0.979
NZ_CP011329_1	1.1\|625417\|47\|NZ_CP011329\|CRT	625417-625463	47	MK448809	Streptococcus phage Javan57, complete genome	26645-26691	1	0.979
NZ_CP011329_1	1.1\|625417\|47\|NZ_CP011329\|CRT	625417-625463	47	MK448872	Streptococcus phage Javan20, complete genome	26645-26691	1	0.979
NZ_CP011329_1	1.1\|625417\|47\|NZ_CP011329\|CRT	625417-625463	47	MK448802	Streptococcus phage Javan55, complete genome	26645-26691	1	0.979
NZ_CP011329_1	1.1\|625417\|47\|NZ_CP011329\|CRT	625417-625463	47	MK448999	Streptococcus phage Javan638, complete genome	24540-24586	1	0.979
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448776	Streptococcus phage Javan49, complete genome	26537-26583	1	0.979
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK449007	Streptococcus phage Javan8, complete genome	26523-26569	1	0.979
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448787	Streptococcus phage Javan51, complete genome	26523-26569	1	0.979
NZ_CP011329_2	2.1\|921427\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921427-921456	30	MK448938	Streptococcus phage Javan44, complete genome	16517-16546	1	0.967
NZ_CP011329_2	2.4\|921625\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921625-921654	30	MK448796	Streptococcus phage Javan53, complete genome	13207-13236	1	0.967
NZ_CP011329_2	2.11\|922087\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	922087-922116	30	MK448956	Streptococcus phage Javan48, complete genome	14516-14545	1	0.967
NZ_CP011329_2	2.11\|922087\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	922087-922116	30	MK448749	Streptococcus phage Javan39, complete genome	14516-14545	1	0.967
NZ_CP011329_1	1.1\|625417\|47\|NZ_CP011329\|CRT	625417-625463	47	MK448695	Streptococcus phage Javan181, complete genome	25465-25511	2	0.957
NZ_CP011329_1	1.1\|625417\|47\|NZ_CP011329\|CRT	625417-625463	47	MK448935	Streptococcus phage Javan424, complete genome	26621-26667	2	0.957
NZ_CP011329_1	1.1\|625417\|47\|NZ_CP011329\|CRT	625417-625463	47	MK448936	Streptococcus phage Javan426, complete genome	26621-26667	2	0.957
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448668	Streptococcus phage Javan107, complete genome	26538-26584	2	0.957
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448666	Streptococcus phage Javan101, complete genome	26538-26584	2	0.957
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448840	Streptococcus phage Javan104, complete genome	26538-26584	2	0.957
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448670	Streptococcus phage Javan113, complete genome	26487-26533	2	0.957
NZ_CP011329_2	2.7\|921823\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921823-921852	30	MK448940	Streptococcus phage Javan444, complete genome	9600-9629	2	0.933
NZ_CP011329_2	2.9\|921955\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921955-921984	30	MK448971	Streptococcus phage Javan52, complete genome	37293-37322	2	0.933
NZ_CP011329_2	2.9\|921955\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921955-921984	30	MK448829	Streptococcus phage Javan7, complete genome	31986-32015	2	0.933
NZ_CP011329_2	2.9\|921955\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921955-921984	30	MH853355	Streptococcus phage LF1, complete genome	22843-22872	2	0.933
NZ_CP011329_2	2.9\|921955\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921955-921984	30	MH853358	Streptococcus phage LF4, complete genome	22843-22872	2	0.933
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448928	Streptococcus phage Javan40, complete genome	26777-26823	3	0.936
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448728	Streptococcus phage Javan3, complete genome	26781-26827	3	0.936
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK449011	Streptococcus phage Javan92, complete genome	26163-26209	3	0.936
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448835	Streptococcus phage Javan93, complete genome	26163-26209	3	0.936
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448836	Streptococcus phage Javan95, complete genome	27238-27284	3	0.936
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448809	Streptococcus phage Javan57, complete genome	26777-26823	3	0.936
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448872	Streptococcus phage Javan20, complete genome	26777-26823	3	0.936
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448825	Streptococcus phage Javan639, complete genome	27238-27284	3	0.936
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448802	Streptococcus phage Javan55, complete genome	26777-26823	3	0.936
NZ_CP011329_1	1.3\|625549\|47\|NZ_CP011329\|CRT	625549-625595	47	MK448999	Streptococcus phage Javan638, complete genome	24672-24718	3	0.936
NZ_CP011329_2	2.7\|921823\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921823-921852	30	MK448848	Streptococcus phage Javan126, complete genome	9056-9085	3	0.9
NZ_CP011329_2	2.7\|921823\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921823-921852	30	MK448857	Streptococcus phage Javan164, complete genome	9056-9085	3	0.9
NZ_CP011329_2	2.7\|921823\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921823-921852	30	MK448677	Streptococcus phage Javan133, complete genome	10048-10077	3	0.9
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448928	Streptococcus phage Javan40, complete genome	26711-26757	4	0.915
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448922	Streptococcus phage Javan38, complete genome	26405-26451	4	0.915
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448728	Streptococcus phage Javan3, complete genome	26715-26761	4	0.915
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448717	Streptococcus phage Javan25, complete genome	26405-26451	4	0.915
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448906	Streptococcus phage Javan32, complete genome	26405-26451	4	0.915
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448836	Streptococcus phage Javan95, complete genome	27172-27218	4	0.915
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448809	Streptococcus phage Javan57, complete genome	26711-26757	4	0.915
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448827	Streptococcus phage Javan65, complete genome	26405-26451	4	0.915
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448872	Streptococcus phage Javan20, complete genome	26711-26757	4	0.915
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448825	Streptococcus phage Javan639, complete genome	27172-27218	4	0.915
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448802	Streptococcus phage Javan55, complete genome	26711-26757	4	0.915
NZ_CP011329_1	1.2\|625483\|47\|NZ_CP011329\|CRT	625483-625529	47	MK448999	Streptococcus phage Javan638, complete genome	24606-24652	4	0.915
NZ_CP011329_2	2.5\|921691\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921691-921720	30	KT151959	Brevibacillus phage Sundance, complete genome	73389-73418	5	0.833
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	NZ_LR134418	Legionella adelaidensis strain NCTC12735 genome assembly, plasmid: 9	292766-292795	6	0.8
NZ_CP011329_2	2.16\|922417\|30\|NZ_CP011329\|CRISPRCasFinder,CRT	922417-922446	30	NC_047897	Lactobacillus phage Lenus, complete genome	65427-65456	6	0.8
NZ_CP011329_2	2.16\|922417\|30\|NZ_CP011329\|CRISPRCasFinder,CRT	922417-922446	30	AP013698	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C55A-MedDCM-OCT-S36-C68, * SEQUENCING IN PROGRESS *	17874-17903	6	0.8
NZ_CP011329_2	2.9\|921955\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921955-921984	30	MT430910	Streptococcus phage smHBZ8, complete genome	14594-14623	7	0.767
NZ_CP011329_2	2.16\|922417\|30\|NZ_CP011329\|CRISPRCasFinder,CRT	922417-922446	30	NC_047925	Lactobacillus phage Nyseid, complete genome	67879-67908	7	0.767
NZ_CP011329_2	2.16\|922417\|30\|NZ_CP011329\|CRISPRCasFinder,CRT	922417-922446	30	KU052488	Lactobacillus phage SA-C12, complete genome	24549-24578	7	0.767
NZ_CP011329_2	2.16\|922417\|30\|NZ_CP011329\|CRISPRCasFinder,CRT	922417-922446	30	MN693473	Marine virus AFVG_25M504, complete genome	22237-22266	7	0.767
NZ_CP011329_3	3.2\|2037772\|31\|NZ_CP011329\|CRT	2037772-2037802	31	NC_047926	Lactobacillus phage Semele, complete genome	8767-8797	7	0.774
NZ_CP011329_3	3.2\|2037772\|31\|NZ_CP011329\|CRT	2037772-2037802	31	NZ_CP040345	Bacillus albus strain DLOU-Yingkou plasmid unnamed1, complete sequence	468537-468567	7	0.774
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	NC_014389	Butyrivibrio proteoclasticus B316 plasmid pCY360, complete sequence	89228-89257	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	NZ_CP039703	Clostridium butyricum strain 29-1 plasmid p-butyl_plas_29-1, complete sequence	22382-22411	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	NZ_CP039706	Clostridium butyricum strain 4-1 plasmid p-butyl_plas_4-1, complete sequence	110578-110607	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	NZ_CP007453	Peptoclostridium acidaminophilum DSM 3953 strain al-2 plasmid EAL2_808p, complete sequence	1807-1836	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	NZ_CP014929	Lactobacillus paracollinoides strain TMW 1.1995 plasmid pL11995-5, complete sequence	4518-4547	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	NZ_CP033246	Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence	544241-544270	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	NZ_CP033246	Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence	715248-715277	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	NZ_CP033248	Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence	544290-544319	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	NZ_CP033248	Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence	715264-715293	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	NZ_AP019717	Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence	645889-645918	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	LR746310	Klebsiella phage vB_KpnM_05F genome assembly, chromosome: 1	125568-125597	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	MT157285	Klebsiella phage P-KP2, complete genome	148204-148233	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	HQ918180	Klebsiella phage KP27, complete genome	111147-111176	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	KT001918	Klebsiella phage Matisse, complete genome	114145-114174	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	KX130727	Escherichia phage phT4A, partial genome	106647-106676	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	KT321315	Enterobacter phage phiEap-3, complete genome	112834-112863	8	0.733
NZ_CP011329_2	2.2\|921493\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921493-921522	30	MN101221	Klebsiella phage KOX8, complete genome	120508-120537	8	0.733
NZ_CP011329_2	2.6\|921757\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921757-921786	30	NZ_CP034117	Staphylococcus epidermidis strain CDC121 plasmid pSTA482, complete sequence	17794-17823	8	0.733
NZ_CP011329_2	2.16\|922417\|30\|NZ_CP011329\|CRISPRCasFinder,CRT	922417-922446	30	AP018932	Escherichia phage KIT03 DNA, complete sequence	154828-154857	8	0.733
NZ_CP011329_3	3.2\|2037772\|31\|NZ_CP011329\|CRT	2037772-2037802	31	MN694353	Marine virus AFVG_250M583, complete genome	53475-53505	8	0.742
NZ_CP011329_2	2.5\|921691\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921691-921720	30	NZ_CP009292	Novosphingobium pentaromativorans US6-1 plasmid pLA3, complete sequence	37192-37221	9	0.7
NZ_CP011329_2	2.5\|921691\|30\|NZ_CP011329\|PILER-CR,CRISPRCasFinder,CRT	921691-921720	30	NZ_CP045273	Bacillus megaterium strain FDU301 plasmid pFDU301A, complete sequence	86434-86463	9	0.7

1. spacer 1.1|625417|47|NZ_CP011329|CRT matches to MK448726 (Streptococcus phage Javan29, complete genome) position: , mismatch: 0, identity: 1.0

caccatgacaaacttacttaatagtatcaaatctgtcgttagtaatg	CRISPR spacer
caccatgacaaacttacttaatagtatcaaatctgtcgttagtaatg	Protospacer
***********************************************

2. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448726 (Streptococcus phage Javan29, complete genome) position: , mismatch: 0, identity: 1.0

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatcgagtattggttcaacggtatcttcta	Protospacer
***********************************************

3. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448726 (Streptococcus phage Javan29, complete genome) position: , mismatch: 0, identity: 1.0

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	Protospacer
***********************************************

4. spacer 2.1|921427|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448829 (Streptococcus phage Javan7, complete genome) position: , mismatch: 0, identity: 1.0

agttatcaatgctatatggtttctcatctt	CRISPR spacer
agttatcaatgctatatggtttctcatctt	Protospacer
******************************

5. spacer 2.1|921427|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448736 (Streptococcus phage Javan35, complete genome) position: , mismatch: 0, identity: 1.0

agttatcaatgctatatggtttctcatctt	CRISPR spacer
agttatcaatgctatatggtttctcatctt	Protospacer
******************************

6. spacer 2.1|921427|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448781 (Streptococcus phage Javan5, complete genome) position: , mismatch: 0, identity: 1.0

agttatcaatgctatatggtttctcatctt	CRISPR spacer
agttatcaatgctatatggtttctcatctt	Protospacer
******************************

7. spacer 2.1|921427|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MH853355 (Streptococcus phage LF1, complete genome) position: , mismatch: 0, identity: 1.0

agttatcaatgctatatggtttctcatctt	CRISPR spacer
agttatcaatgctatatggtttctcatctt	Protospacer
******************************

8. spacer 2.1|921427|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448911 (Streptococcus phage Javan34, complete genome) position: , mismatch: 0, identity: 1.0

agttatcaatgctatatggtttctcatctt	CRISPR spacer
agttatcaatgctatatggtttctcatctt	Protospacer
******************************

9. spacer 2.1|921427|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448837 (Streptococcus phage Javan10, complete genome) position: , mismatch: 0, identity: 1.0

agttatcaatgctatatggtttctcatctt	CRISPR spacer
agttatcaatgctatatggtttctcatctt	Protospacer
******************************

10. spacer 2.1|921427|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448742 (Streptococcus phage Javan37, complete genome) position: , mismatch: 0, identity: 1.0

agttatcaatgctatatggtttctcatctt	CRISPR spacer
agttatcaatgctatatggtttctcatctt	Protospacer
******************************

11. spacer 2.1|921427|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MH853358 (Streptococcus phage LF4, complete genome) position: , mismatch: 0, identity: 1.0

agttatcaatgctatatggtttctcatctt	CRISPR spacer
agttatcaatgctatatggtttctcatctt	Protospacer
******************************

12. spacer 2.1|921427|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448916 (Streptococcus phage Javan36, complete genome) position: , mismatch: 0, identity: 1.0

agttatcaatgctatatggtttctcatctt	CRISPR spacer
agttatcaatgctatatggtttctcatctt	Protospacer
******************************

13. spacer 2.4|921625|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MH853356 (Streptococcus phage LF2, partial genome) position: , mismatch: 0, identity: 1.0

ggcgaacttgtaacgtttgacggtaatttt	CRISPR spacer
ggcgaacttgtaacgtttgacggtaatttt	Protospacer
******************************

14. spacer 2.4|921625|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448971 (Streptococcus phage Javan52, complete genome) position: , mismatch: 0, identity: 1.0

ggcgaacttgtaacgtttgacggtaatttt	CRISPR spacer
ggcgaacttgtaacgtttgacggtaatttt	Protospacer
******************************

15. spacer 2.7|921823|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448932 (Streptococcus phage Javan42, complete genome) position: , mismatch: 0, identity: 1.0

tatttcatcatagaaaatcctgctagtggt	CRISPR spacer
tatttcatcatagaaaatcctgctagtggt	Protospacer
******************************

16. spacer 2.7|921823|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448669 (Streptococcus phage Javan11, complete genome) position: , mismatch: 0, identity: 1.0

tatttcatcatagaaaatcctgctagtggt	CRISPR spacer
tatttcatcatagaaaatcctgctagtggt	Protospacer
******************************

17. spacer 2.8|921889|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448956 (Streptococcus phage Javan48, complete genome) position: , mismatch: 0, identity: 1.0

gcgatgatggtaagtcatcatggacagcgt	CRISPR spacer
gcgatgatggtaagtcatcatggacagcgt	Protospacer
******************************

18. spacer 2.8|921889|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448742 (Streptococcus phage Javan37, complete genome) position: , mismatch: 0, identity: 1.0

gcgatgatggtaagtcatcatggacagcgt	CRISPR spacer
gcgatgatggtaagtcatcatggacagcgt	Protospacer
******************************

19. spacer 2.8|921889|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to JX409894 (Streptococcus phage LYGO9, complete genome) position: , mismatch: 0, identity: 1.0

gcgatgatggtaagtcatcatggacagcgt	CRISPR spacer
gcgatgatggtaagtcatcatggacagcgt	Protospacer
******************************

20. spacer 2.8|921889|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to JX409895 (Streptococcus phage JX01, complete genome) position: , mismatch: 0, identity: 1.0

gcgatgatggtaagtcatcatggacagcgt	CRISPR spacer
gcgatgatggtaagtcatcatggacagcgt	Protospacer
******************************

21. spacer 2.9|921955|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448837 (Streptococcus phage Javan10, complete genome) position: , mismatch: 0, identity: 1.0

ttttacacacgatgtcagatataatgtcaa	CRISPR spacer
ttttacacacgatgtcagatataatgtcaa	Protospacer
******************************

22. spacer 2.11|922087|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448971 (Streptococcus phage Javan52, complete genome) position: , mismatch: 0, identity: 1.0

cgtaccatctatcaatttaccgcaagctgt	CRISPR spacer
cgtaccatctatcaatttaccgcaagctgt	Protospacer
******************************

23. spacer 2.11|922087|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448829 (Streptococcus phage Javan7, complete genome) position: , mismatch: 0, identity: 1.0

cgtaccatctatcaatttaccgcaagctgt	CRISPR spacer
cgtaccatctatcaatttaccgcaagctgt	Protospacer
******************************

24. spacer 2.11|922087|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MH853355 (Streptococcus phage LF1, complete genome) position: , mismatch: 0, identity: 1.0

cgtaccatctatcaatttaccgcaagctgt	CRISPR spacer
cgtaccatctatcaatttaccgcaagctgt	Protospacer
******************************

25. spacer 2.11|922087|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MH853356 (Streptococcus phage LF2, partial genome) position: , mismatch: 0, identity: 1.0

cgtaccatctatcaatttaccgcaagctgt	CRISPR spacer
cgtaccatctatcaatttaccgcaagctgt	Protospacer
******************************

26. spacer 2.11|922087|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448837 (Streptococcus phage Javan10, complete genome) position: , mismatch: 0, identity: 1.0

cgtaccatctatcaatttaccgcaagctgt	CRISPR spacer
cgtaccatctatcaatttaccgcaagctgt	Protospacer
******************************

27. spacer 2.11|922087|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MH853358 (Streptococcus phage LF4, complete genome) position: , mismatch: 0, identity: 1.0

cgtaccatctatcaatttaccgcaagctgt	CRISPR spacer
cgtaccatctatcaatttaccgcaagctgt	Protospacer
******************************

28. spacer 1.1|625417|47|NZ_CP011329|CRT matches to MK448928 (Streptococcus phage Javan40, complete genome) position: , mismatch: 1, identity: 0.979

caccatgacaaacttacttaatagtatcaaatctgtcgttagtaatg	CRISPR spacer
caccatgacaaacttactaaatagtatcaaatctgtcgttagtaatg	Protospacer
****************** ****************************

29. spacer 1.1|625417|47|NZ_CP011329|CRT matches to MK448728 (Streptococcus phage Javan3, complete genome) position: , mismatch: 1, identity: 0.979

caccatgacaaacttacttaatagtatcaaatctgtcgttagtaatg	CRISPR spacer
caccatgacaaacttactaaatagtatcaaatctgtcgttagtaatg	Protospacer
****************** ****************************

30. spacer 1.1|625417|47|NZ_CP011329|CRT matches to MK448809 (Streptococcus phage Javan57, complete genome) position: , mismatch: 1, identity: 0.979

caccatgacaaacttacttaatagtatcaaatctgtcgttagtaatg	CRISPR spacer
caccatgacaaacttactaaatagtatcaaatctgtcgttagtaatg	Protospacer
****************** ****************************

31. spacer 1.1|625417|47|NZ_CP011329|CRT matches to MK448872 (Streptococcus phage Javan20, complete genome) position: , mismatch: 1, identity: 0.979

caccatgacaaacttacttaatagtatcaaatctgtcgttagtaatg	CRISPR spacer
caccatgacaaacttactaaatagtatcaaatctgtcgttagtaatg	Protospacer
****************** ****************************

32. spacer 1.1|625417|47|NZ_CP011329|CRT matches to MK448802 (Streptococcus phage Javan55, complete genome) position: , mismatch: 1, identity: 0.979

caccatgacaaacttacttaatagtatcaaatctgtcgttagtaatg	CRISPR spacer
caccatgacaaacttactaaatagtatcaaatctgtcgttagtaatg	Protospacer
****************** ****************************

33. spacer 1.1|625417|47|NZ_CP011329|CRT matches to MK448999 (Streptococcus phage Javan638, complete genome) position: , mismatch: 1, identity: 0.979

caccatgacaaacttacttaatagtatcaaatctgtcgttagtaatg	CRISPR spacer
caccatgacaaacttactcaatagtatcaaatctgtcgttagtaatg	Protospacer
******************.****************************

34. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448776 (Streptococcus phage Javan49, complete genome) position: , mismatch: 1, identity: 0.979

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
aacgattagttccattctatcgagtattggttcaacggtatcttcta	Protospacer
 **********************************************

35. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK449007 (Streptococcus phage Javan8, complete genome) position: , mismatch: 1, identity: 0.979

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
aacgattagttccattctatcgagtattggttcaacggtatcttcta	Protospacer
 **********************************************

36. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448787 (Streptococcus phage Javan51, complete genome) position: , mismatch: 1, identity: 0.979

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
aacgattagttccattctatcgagtattggttcaacggtatcttcta	Protospacer
 **********************************************

37. spacer 2.1|921427|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448938 (Streptococcus phage Javan44, complete genome) position: , mismatch: 1, identity: 0.967

agttatcaatgctatatggtttctcatctt	CRISPR spacer
agttatcaatgctatatggtttttcatctt	Protospacer
**********************.*******

38. spacer 2.4|921625|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448796 (Streptococcus phage Javan53, complete genome) position: , mismatch: 1, identity: 0.967

ggcgaacttgtaacgtttgacggtaatttt	CRISPR spacer
ggcgaacttgtaacttttgacggtaatttt	Protospacer
************** ***************

39. spacer 2.11|922087|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448956 (Streptococcus phage Javan48, complete genome) position: , mismatch: 1, identity: 0.967

cgtaccatctatcaatttaccgcaagctgt	CRISPR spacer
tgtaccatctatcaatttaccgcaagctgt	Protospacer
.*****************************

40. spacer 2.11|922087|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448749 (Streptococcus phage Javan39, complete genome) position: , mismatch: 1, identity: 0.967

cgtaccatctatcaatttaccgcaagctgt	CRISPR spacer
tgtaccatctatcaatttaccgcaagctgt	Protospacer
.*****************************

41. spacer 1.1|625417|47|NZ_CP011329|CRT matches to MK448695 (Streptococcus phage Javan181, complete genome) position: , mismatch: 2, identity: 0.957

caccatgacaaacttacttaatagtatcaaatctgtcgttagtaatg	CRISPR spacer
cagcatgacaaacttactcaatagtatcaaatctgtcgttagtaatg	Protospacer
** ***************.****************************

42. spacer 1.1|625417|47|NZ_CP011329|CRT matches to MK448935 (Streptococcus phage Javan424, complete genome) position: , mismatch: 2, identity: 0.957

caccatgacaaacttacttaatagtatcaaatctgtcgttagtaatg	CRISPR spacer
cactatgacaaacttactcaatagtatcaaatctgtcgttagtaatg	Protospacer
***.**************.****************************

43. spacer 1.1|625417|47|NZ_CP011329|CRT matches to MK448936 (Streptococcus phage Javan426, complete genome) position: , mismatch: 2, identity: 0.957

caccatgacaaacttacttaatagtatcaaatctgtcgttagtaatg	CRISPR spacer
cactatgacaaacttactcaatagtatcaaatctgtcgttagtaatg	Protospacer
***.**************.****************************

44. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448668 (Streptococcus phage Javan107, complete genome) position: , mismatch: 2, identity: 0.957

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
aaccatctcaggtgtcctaagtggtatttcaagcacagtgtcctctg	Protospacer
********************************.******* ******

45. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448666 (Streptococcus phage Javan101, complete genome) position: , mismatch: 2, identity: 0.957

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
aaccatctcaggtgtcctaagtggtatttcaagcacagtgtcctctg	Protospacer
********************************.******* ******

46. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448840 (Streptococcus phage Javan104, complete genome) position: , mismatch: 2, identity: 0.957

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
aaccatctcaggtgtcctaagtggtatttcaagcacagtgtcctctg	Protospacer
********************************.******* ******

47. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448670 (Streptococcus phage Javan113, complete genome) position: , mismatch: 2, identity: 0.957

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
aaccatctcaggtgtcctaagtggtatttcaagcacagtgtcctctg	Protospacer
********************************.******* ******

48. spacer 2.7|921823|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448940 (Streptococcus phage Javan444, complete genome) position: , mismatch: 2, identity: 0.933

tatttcatcatagaaaatcctgctagtggt	CRISPR spacer
tatttcataatagaaaatccagctagtggt	Protospacer
******** *********** *********

49. spacer 2.9|921955|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448971 (Streptococcus phage Javan52, complete genome) position: , mismatch: 2, identity: 0.933

ttttacacacgatgtcagatataatgtcaa	CRISPR spacer
ttttacacacgatgtcagatacaatgtgaa	Protospacer
*********************.***** **

50. spacer 2.9|921955|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448829 (Streptococcus phage Javan7, complete genome) position: , mismatch: 2, identity: 0.933

ttttacacacgatgtcagatataatgtcaa	CRISPR spacer
ttttacacacgatgtcagatacaatgtgaa	Protospacer
*********************.***** **

51. spacer 2.9|921955|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MH853355 (Streptococcus phage LF1, complete genome) position: , mismatch: 2, identity: 0.933

ttttacacacgatgtcagatataatgtcaa	CRISPR spacer
ttttacacacgatgtcagatacaatgtgaa	Protospacer
*********************.***** **

52. spacer 2.9|921955|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MH853358 (Streptococcus phage LF4, complete genome) position: , mismatch: 2, identity: 0.933

ttttacacacgatgtcagatataatgtcaa	CRISPR spacer
ttttacacacgatgtcagatacaatgtgaa	Protospacer
*********************.***** **

53. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448928 (Streptococcus phage Javan40, complete genome) position: , mismatch: 3, identity: 0.936

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
tactatctcaggtgtcctaagtggtatttcaaacacagtgtcctctg	Protospacer
 **.************************************ ******

54. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448728 (Streptococcus phage Javan3, complete genome) position: , mismatch: 3, identity: 0.936

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
tactatctcaggtgtcctaagtggtatttcaaacacagtgtcctctg	Protospacer
 **.************************************ ******

55. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK449011 (Streptococcus phage Javan92, complete genome) position: , mismatch: 3, identity: 0.936

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
tactatctcaggtgtcctaagtggtatttcaaacacagtgtcctctg	Protospacer
 **.************************************ ******

56. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448835 (Streptococcus phage Javan93, complete genome) position: , mismatch: 3, identity: 0.936

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
tactatctcaggtgtcctaagtggtatttcaaacacagtgtcctctg	Protospacer
 **.************************************ ******

57. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448836 (Streptococcus phage Javan95, complete genome) position: , mismatch: 3, identity: 0.936

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
tactatctcaggtgtcctaagtggtatttcaaacacagtgtcctctg	Protospacer
 **.************************************ ******

58. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448809 (Streptococcus phage Javan57, complete genome) position: , mismatch: 3, identity: 0.936

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
tactatctcaggtgtcctaagtggtatttcaaacacagtgtcctctg	Protospacer
 **.************************************ ******

59. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448872 (Streptococcus phage Javan20, complete genome) position: , mismatch: 3, identity: 0.936

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
tactatctcaggtgtcctaagtggtatttcaaacacagtgtcctctg	Protospacer
 **.************************************ ******

60. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448825 (Streptococcus phage Javan639, complete genome) position: , mismatch: 3, identity: 0.936

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
tactatctcaggtgtcctaagtggtatttcaaacacagtgtcctctg	Protospacer
 **.************************************ ******

61. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448802 (Streptococcus phage Javan55, complete genome) position: , mismatch: 3, identity: 0.936

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
tactatctcaggtgtcctaagtggtatttcaaacacagtgtcctctg	Protospacer
 **.************************************ ******

62. spacer 1.3|625549|47|NZ_CP011329|CRT matches to MK448999 (Streptococcus phage Javan638, complete genome) position: , mismatch: 3, identity: 0.936

aaccatctcaggtgtcctaagtggtatttcaaacacagtgacctctg	CRISPR spacer
tactatctcaggtgtcctaagtggtatttcaaacacagtgtcctctg	Protospacer
 **.************************************ ******

63. spacer 2.7|921823|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448848 (Streptococcus phage Javan126, complete genome) position: , mismatch: 3, identity: 0.9

tatttcatcatagaaaatcctgctagtggt	CRISPR spacer
tatttcatcattgaaaatccagctagtggc	Protospacer
*********** ******** ********.

64. spacer 2.7|921823|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448857 (Streptococcus phage Javan164, complete genome) position: , mismatch: 3, identity: 0.9

tatttcatcatagaaaatcctgctagtggt	CRISPR spacer
tatttcatcattgaaaatccagctagtggc	Protospacer
*********** ******** ********.

65. spacer 2.7|921823|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MK448677 (Streptococcus phage Javan133, complete genome) position: , mismatch: 3, identity: 0.9

tatttcatcatagaaaatcctgctagtggt	CRISPR spacer
tatttcatcattgaaaatccagctagtggc	Protospacer
*********** ******** ********.

66. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448928 (Streptococcus phage Javan40, complete genome) position: , mismatch: 4, identity: 0.915

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatctagtattggctcaacggtatcttccg	Protospacer
********************* ********.**************..

67. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448922 (Streptococcus phage Javan38, complete genome) position: , mismatch: 4, identity: 0.915

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatctagtattggctcaacggtatcttccg	Protospacer
********************* ********.**************..

68. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448728 (Streptococcus phage Javan3, complete genome) position: , mismatch: 4, identity: 0.915

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatctagtattggctcaacggtatcttccg	Protospacer
********************* ********.**************..

69. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448717 (Streptococcus phage Javan25, complete genome) position: , mismatch: 4, identity: 0.915

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatctagtattggctcaacggtatcttccg	Protospacer
********************* ********.**************..

70. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448906 (Streptococcus phage Javan32, complete genome) position: , mismatch: 4, identity: 0.915

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatctagtattggctcaacggtatcttccg	Protospacer
********************* ********.**************..

71. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448836 (Streptococcus phage Javan95, complete genome) position: , mismatch: 4, identity: 0.915

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatcgagtattggcgcaacggtatcttccg	Protospacer
******************************. *************..

72. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448809 (Streptococcus phage Javan57, complete genome) position: , mismatch: 4, identity: 0.915

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatctagtattggctcaacggtatcttccg	Protospacer
********************* ********.**************..

73. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448827 (Streptococcus phage Javan65, complete genome) position: , mismatch: 4, identity: 0.915

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatctagtattggctcaacggtatcttccg	Protospacer
********************* ********.**************..

74. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448872 (Streptococcus phage Javan20, complete genome) position: , mismatch: 4, identity: 0.915

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatctagtattggctcaacggtatcttccg	Protospacer
********************* ********.**************..

75. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448825 (Streptococcus phage Javan639, complete genome) position: , mismatch: 4, identity: 0.915

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatcgagtattggcgcaacggtatcttccg	Protospacer
******************************. *************..

76. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448802 (Streptococcus phage Javan55, complete genome) position: , mismatch: 4, identity: 0.915

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatctagtattggctcaacggtatcttccg	Protospacer
********************* ********.**************..

77. spacer 1.2|625483|47|NZ_CP011329|CRT matches to MK448999 (Streptococcus phage Javan638, complete genome) position: , mismatch: 4, identity: 0.915

cacgattagttccattctatcgagtattggttcaacggtatcttcta	CRISPR spacer
cacgattagttccattctatctagtattggctcaacggtatcttccg	Protospacer
********************* ********.**************..

78. spacer 2.5|921691|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to KT151959 (Brevibacillus phage Sundance, complete genome) position: , mismatch: 5, identity: 0.833

-taatgtcttttcctagaatgtacatttcta	CRISPR spacer
attttgt-ttttccttgaatggacatttcta	Protospacer
 *  *** ******* ***** *********

79. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134418 (Legionella adelaidensis strain NCTC12735 genome assembly, plasmid: 9) position: , mismatch: 6, identity: 0.8

gtttaattttgaataatatcatgtttactc	CRISPR spacer
ctttaattttgaaaaatatcattttaattt	Protospacer
 ************ ******** ** *.*.

80. spacer 2.16|922417|30|NZ_CP011329|CRISPRCasFinder,CRT matches to NC_047897 (Lactobacillus phage Lenus, complete genome) position: , mismatch: 6, identity: 0.8

tggttatacatttactaatccatcagcatt	CRISPR spacer
ggatggtactgttactaatccatcagcatt	Protospacer
 *.* .***  *******************

81. spacer 2.16|922417|30|NZ_CP011329|CRISPRCasFinder,CRT matches to AP013698 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C55A-MedDCM-OCT-S36-C68, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 6, identity: 0.8

-tggttatacatttactaatccatcagcatt	CRISPR spacer
ctcagta-acagttactaatacatcagcatt	Protospacer
 * . ** *** ******** **********

82. spacer 2.9|921955|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MT430910 (Streptococcus phage smHBZ8, complete genome) position: , mismatch: 7, identity: 0.767

ttttacacacgatgtcagatataatgtcaa	CRISPR spacer
ctttacacacgatatcagatatagttatga	Protospacer
.************.*********.*  ..*

83. spacer 2.16|922417|30|NZ_CP011329|CRISPRCasFinder,CRT matches to NC_047925 (Lactobacillus phage Nyseid, complete genome) position: , mismatch: 7, identity: 0.767

tggttatacatttactaatccatcagcatt	CRISPR spacer
ggacggtactgttactaatccatcagcatt	Protospacer
 *.. .***  *******************

84. spacer 2.16|922417|30|NZ_CP011329|CRISPRCasFinder,CRT matches to KU052488 (Lactobacillus phage SA-C12, complete genome) position: , mismatch: 7, identity: 0.767

tggttatacatttactaatccatcagcatt	CRISPR spacer
ggacggtactgttactaatccatcagcatt	Protospacer
 *.. .***  *******************

85. spacer 2.16|922417|30|NZ_CP011329|CRISPRCasFinder,CRT matches to MN693473 (Marine virus AFVG_25M504, complete genome) position: , mismatch: 7, identity: 0.767

tggttatacatttactaatccatcagcatt	CRISPR spacer
tggtgatacatttactaatcctatgccatc	Protospacer
**** ****************  .. ***.

86. spacer 3.2|2037772|31|NZ_CP011329|CRT matches to NC_047926 (Lactobacillus phage Semele, complete genome) position: , mismatch: 7, identity: 0.774

ggcttaacgtctggcttagcttctggtttgg	CRISPR spacer
gctggaacttctggcttagcttctggttcag	Protospacer
* .  *** *******************..*

87. spacer 3.2|2037772|31|NZ_CP011329|CRT matches to NZ_CP040345 (Bacillus albus strain DLOU-Yingkou plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.774

ggcttaacgtctggcttagcttctggtttgg	CRISPR spacer
ggcttcacttctggcttagcttctttttcta	Protospacer
***** ** ***************  **. .

88. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NC_014389 (Butyrivibrio proteoclasticus B316 plasmid pCY360, complete sequence) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
attttattttgaataatatcatttacatca	Protospacer
.*** ***************** * .*..

89. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039703 (Clostridium butyricum strain 29-1 plasmid p-butyl_plas_29-1, complete sequence) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
tcttgtttttgaataatatcatctttagat	Protospacer
 .**. **************** ****  .

90. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039706 (Clostridium butyricum strain 4-1 plasmid p-butyl_plas_4-1, complete sequence) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
tcttgtttttgaataatatcatctttagat	Protospacer
 .**. **************** ****  .

91. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007453 (Peptoclostridium acidaminophilum DSM 3953 strain al-2 plasmid EAL2_808p, complete sequence) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
ctataatttttaaaaatatcatgtttttat	Protospacer
 * ******* ** ************ . .

92. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014929 (Lactobacillus paracollinoides strain TMW 1.1995 plasmid pL11995-5, complete sequence) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
atttattttttaataatatcatgtaatttt	Protospacer
.**** **** *************   .*.

93. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033246 (Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
tcttgtttttgaataatatcatctttagat	Protospacer
 .**. **************** ****  .

94. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033246 (Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
tcttgtttttgaataatatcatctttagat	Protospacer
 .**. **************** ****  .

95. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033248 (Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
tcttgtttttgaataatatcatctttagat	Protospacer
 .**. **************** ****  .

96. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033248 (Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
tcttgtttttgaataatatcatctttagat	Protospacer
 .**. **************** ****  .

97. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP019717 (Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
tcttgtttttgaataatatcatctttagat	Protospacer
 .**. **************** ****  .

98. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to LR746310 (Klebsiella phage vB_KpnM_05F genome assembly, chromosome: 1) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
ctatctacttgaataatatcaagtttactg	Protospacer
 * *   .************* *******

99. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MT157285 (Klebsiella phage P-KP2, complete genome) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
ctatctacttgaataatatcaagtttactg	Protospacer
 * *   .************* *******

100. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to HQ918180 (Klebsiella phage KP27, complete genome) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
ctatctacttgaataatatcaagtttactg	Protospacer
 * *   .************* *******

101. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to KT001918 (Klebsiella phage Matisse, complete genome) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
ctatctacttgaataatatcaagtttactg	Protospacer
 * *   .************* *******

102. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to KX130727 (Escherichia phage phT4A, partial genome) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
ctatctacttgaataatatcaagtttactg	Protospacer
 * *   .************* *******

103. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to KT321315 (Enterobacter phage phiEap-3, complete genome) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
ctatctacttgaataatatcaagtttactg	Protospacer
 * *   .************* *******

104. spacer 2.2|921493|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to MN101221 (Klebsiella phage KOX8, complete genome) position: , mismatch: 8, identity: 0.733

gtttaattttgaataatatcatgtttactc	CRISPR spacer
ctatctacttgaataatatcaagtttactg	Protospacer
 * *   .************* *******

105. spacer 2.6|921757|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034117 (Staphylococcus epidermidis strain CDC121 plasmid pSTA482, complete sequence) position: , mismatch: 8, identity: 0.733

attactttcaagatgtctatgactatatgc	CRISPR spacer
aagaaattcaagatgtttatgactataaag	Protospacer
*  *  **********.********** .

106. spacer 2.16|922417|30|NZ_CP011329|CRISPRCasFinder,CRT matches to AP018932 (Escherichia phage KIT03 DNA, complete sequence) position: , mismatch: 8, identity: 0.733

tggttatacatttactaatccatcagcatt	CRISPR spacer
gggtaatacatttactaatccaagcgaagg	Protospacer
 *** *****************   * *

107. spacer 3.2|2037772|31|NZ_CP011329|CRT matches to MN694353 (Marine virus AFVG_250M583, complete genome) position: , mismatch: 8, identity: 0.742

ggcttaacgtctggcttagcttctggtttgg	CRISPR spacer
atcttaatgtctgtcttagcttctgtcatgt	Protospacer
. *****.***** *********** . **

108. spacer 2.5|921691|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009292 (Novosphingobium pentaromativorans US6-1 plasmid pLA3, complete sequence) position: , mismatch: 9, identity: 0.7

taatgtcttttcctagaatgtacatttcta	CRISPR spacer
cttcgtctttttctacaatgtacattttct	Protospacer
.  .*******.*** ***********..

109. spacer 2.5|921691|30|NZ_CP011329|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045273 (Bacillus megaterium strain FDU301 plasmid pFDU301A, complete sequence) position: , mismatch: 9, identity: 0.7

taatgtcttttcctagaatgtacatttcta	CRISPR spacer
ctatgtcttttcctagtatgtactcgtacc	Protospacer
. ************** ****** . * .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

40717 : 48823

Synechococcus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000220683.1\|40717_42172_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.4e-53	32.5
WP_001291337.1\|42199_43222_+	phosphoribosylformylglycinamidine cyclo-ligase	R9TMC7	Synechococcus_phage	1.2e-62	42.4
WP_000686114.1\|43389_43938_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.0e-25	35.6
WP_000780022.1\|43960_44713_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_050265479.1\|44732_46280_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	3.0e-78	49.2
WP_001045908.1\|46472_47372_+	peptidoglycan DD-metalloendopeptidase family protein	A0A221J6U0	Arthrobacter_phage	4.1e-19	45.9
WP_000783419.1\|47518_48823_+	LysM peptidoglycan-binding domain-containing protein	A0A2D1GNZ3	Streptomyces_phage	3.7e-05	40.5

DBSCAN-SWA_2

503775 : 562918

Streptococcus_phage(36.36%)

transposase,protease,tRNA,integrase

attL 500066:500081|attR 569205:569220

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
500066:500081	attL	NA	NA	NA	NA
WP_000882549.1\|503775_506037_-\|protease	ATP-dependent Clp protease ATP-binding subunit	A0A2C9CYX3	Yersinia_phage	7.4e-126	39.4
WP_000443582.1\|506334_506565_+	DUF1797 family protein	NA	NA	NA	NA
WP_001011647.1\|506706_507399_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_000230134.1\|507391_508126_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.1e-35	41.8
WP_001106845.1\|508412_510107_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	5.5e-126	42.6
WP_000137498.1\|510245_511100_+	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	A0A249XZQ2	Enterococcus_phage	1.5e-39	40.2
WP_000634981.1\|511096_511933_+	NAD(P)H-hydrate dehydratase	NA	NA	NA	NA
WP_001286939.1\|512058_513399_+	exodeoxyribonuclease VII large subunit	L7RDW5	Acanthamoeba_polyphaga_moumouvirus	3.4e-38	31.7
WP_001280900.1\|513376_513592_+	exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
WP_000256279.1\|513591_514464_+	polyprenyl synthetase family protein	NA	NA	NA	NA
WP_001041040.1\|514456_515284_+	TlyA family rRNA (cytidine-2'-O)-methyltransferase	NA	NA	NA	NA
WP_000747940.1\|515270_515744_+	ArgR family transcriptional regulator	NA	NA	NA	NA
WP_000923619.1\|515755_517414_+	DNA repair protein RecN	NA	NA	NA	NA
WP_000034838.1\|517526_518363_+	DegV family protein	NA	NA	NA	NA
WP_001035227.1\|518355_519195_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_000806954.1\|519169_519772_+	YpmS family protein	NA	NA	NA	NA
WP_001284634.1\|519874_520150_+	HU family DNA-binding protein	A7KV42	Bacillus_phage	1.2e-25	71.9
WP_001290370.1\|520346_520544_+	hypothetical protein	NA	NA	NA	NA
WP_000254063.1\|520587_521520_-	dihydroorotate oxidase	A0A1V0SH91	Hokovirus	6.7e-65	43.7
WP_001185391.1\|521706_522942_-	aminoacyltransferase	NA	NA	NA	NA
WP_000285514.1\|522960_524172_-	aminoacyltransferase	NA	NA	NA	NA
WP_000527090.1\|524184_525420_-	aminoacyltransferase	NA	NA	NA	NA
WP_000200668.1\|525404_526217_-	sugar-phosphatase	NA	NA	NA	NA
WP_001003543.1\|526287_527604_-	HD domain-containing protein	E3T4P8	Cafeteria_roenbergensis_virus	8.1e-24	29.6
WP_001209458.1\|527667_528066_+	DUF1934 domain-containing protein	NA	NA	NA	NA
WP_000910746.1\|528409_531094_+	calcium-translocating P-type ATPase, PMCA-type	M1IAU8	Acanthocystis_turfacea_Chlorella_virus	1.1e-70	29.3
WP_000163483.1\|531138_531999_-	phosphoesterase	NA	NA	NA	NA
WP_000064640.1\|532150_534082_+	fructose-1,6-bisphosphatase	NA	NA	NA	NA
WP_000351637.1\|534171_535296_+\|tRNA	tRNA epoxyqueuosine(34) reductase QueG	NA	NA	NA	NA
WP_011324939.1\|535364_536462_+	peptide chain release factor 2	NA	NA	NA	NA
WP_001173889.1\|536481_537174_+	cell division ATP-binding protein FtsE	G9BWD6	Planktothrix_phage	1.3e-28	35.1
WP_000236202.1\|537157_538087_+	ABC transporter permease	NA	NA	NA	NA
WP_001022571.1\|538139_538850_-	thioesterase	NA	NA	NA	NA
WP_001115859.1\|538846_539545_-	MBL fold metallo-hydrolase	A0A1X9I5D3	Streptococcus_phage	1.5e-82	64.9
WP_000048144.1\|539712_540477_+	(S)-acetoin forming diacetyl reductase	V5L4T3	Hirudovirus	9.8e-06	31.8
WP_000458614.1\|540584_543092_+	bifunctional DnaQ family exonuclease/ATP-dependent helicase	A0A1X9I5C8	Streptococcus_phage	2.0e-217	50.3
WP_000221826.1\|543177_544371_+	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_000038470.1\|544391_545738_+\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	1.3e-56	31.4
WP_000167491.1\|545777_546335_-	ECF transporter S component	NA	NA	NA	NA
WP_001031097.1\|546331_547315_-	hypothetical protein	NA	NA	NA	NA
WP_000965180.1\|547560_547974_-	hypothetical protein	NA	NA	NA	NA
WP_001278848.1\|548127_549018_+	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	5.7e-05	28.1
WP_001231102.1\|549014_549989_+	YvcK family protein	A1IMD5	Streptococcus_phage	9.8e-144	78.8
WP_000011316.1\|549985_550897_+	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	1.4e-107	65.7
WP_000752457.1\|550911_552309_+	C69 family dipeptidase	NA	NA	NA	NA
WP_001227406.1\|552450_553971_+	zinc ABC transporter substrate-binding protein AdcA	NA	NA	NA	NA
WP_000710757.1\|554083_554344_-	type B 50S ribosomal protein L31	NA	NA	NA	NA
WP_000583238.1\|554452_555388_-	bifunctional oligoribonuclease/PAP phosphatase NrnA	NA	NA	NA	NA
WP_000189639.1\|555653_556676_+	adenosine deaminase	NA	NA	NA	NA
WP_001162136.1\|556734_557178_+	flavodoxin	NA	NA	NA	NA
WP_000418127.1\|557254_557530_+	chorismate mutase	NA	NA	NA	NA
WP_000595708.1\|557522_558719_+	voltage-gated chloride channel family protein	A0A1X9I5Z9	Streptococcus_phage	4.6e-103	54.5
WP_088181596.1\|559171_559976_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_001068667.1\|560159_560507_+	50S ribosomal protein L19	NA	NA	NA	NA
WP_071659971.1\|560651_561266_-\|integrase	site-specific integrase	F8HGP4	Streptococcus_phage	9.2e-55	60.7
WP_001872365.1\|561268_561535_-	hypothetical protein	Q77YW7	Streptococcus_phage	9.2e-20	65.2
WP_000640620.1\|561534_561939_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_001122304.1\|562100_562301_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_001865698.1\|562322_562583_+\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	3.4e-11	43.0
WP_001867107.1\|562708_562918_+\|transposase	transposase	A0A0C5AEA5	Paenibacillus_phage	1.4e-15	55.4
569205:569220	attR	NA	NA	NA	NA

DBSCAN-SWA_3

578630 : 633668

Streptococcus_phage(100.0%)

portal,capsid,transposase,terminase,head,holin,protease,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000564846.1\|578630_579764_-\|transposase	ISAs1-like element IS1548 family transposase	NA	NA	NA	NA
WP_000022832.1\|579998_581306_+	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	1.5e-235	95.4
WP_000823924.1\|581413_582478_-	hypothetical protein	NA	NA	NA	NA
WP_000772014.1\|582706_583990_+	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_001127193.1\|583982_584495_+	shikimate kinase	NA	NA	NA	NA
WP_000089337.1\|584551_585925_+	LCP family protein	NA	NA	NA	NA
WP_000902655.1\|586025_587381_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	D0R096	Streptococcus_phage	3.9e-191	73.4
WP_017649105.1\|588907_589438_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_151383508.1\|589607_595136_+	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_000459851.1\|595995_597864_+	XRE family transcriptional regulator	E4ZFJ9	Streptococcus_phage	3.6e-304	81.2
WP_001122248.1\|598272_598842_+	hypothetical protein	A0A1B0RXB3	Streptococcus_phage	2.5e-86	81.0
WP_000905643.1\|598880_600836_-	DNA polymerase	D0R0B0	Streptococcus_phage	0.0e+00	84.3
WP_000208945.1\|601066_601630_-	DUF2815 family protein	A0A1B0RXA9	Streptococcus_phage	1.9e-91	93.9
WP_001914156.1\|601634_602756_-	DUF2800 domain-containing protein	A0A1X9I6D8	Streptococcus_phage	8.0e-198	88.2
WP_000041407.1\|602748_603072_-	hypothetical protein	A0A1B0RXB7	Streptococcus_phage	2.0e-32	71.2
WP_001160921.1\|603468_605751_+	hypothetical protein	A0A1B0RXC5	Streptococcus_phage	0.0e+00	79.6
WP_001208492.1\|606034_606316_+	VRR-NUC domain-containing protein	M1PFY8	Streptococcus_phage	7.9e-38	79.6
WP_000768925.1\|606296_607673_+	DEAD/DEAH box helicase	A0A1X9I6B0	Streptococcus_phage	1.8e-231	86.2
WP_000361944.1\|607665_608163_+	hypothetical protein	A0A1B0RXB9	Streptococcus_phage	1.7e-62	74.4
WP_000640706.1\|608555_609593_+	methionine adenosyltransferase	E4ZFL0	Streptococcus_phage	1.9e-169	84.6
WP_001138031.1\|609594_609960_+	HNH endonuclease	A0A1B0RXJ3	Streptococcus_phage	6.6e-61	86.0
WP_000999417.1\|610248_610704_+	hypothetical protein	M1Q209	Streptococcus_phage	2.1e-43	51.0
WP_000211624.1\|610675_611932_+	DNA modification methylase	A0A1B0RXJ0	Streptococcus_phage	1.8e-222	88.7
WP_000164558.1\|613243_613498_+	hypothetical protein	NA	NA	NA	NA
WP_000999360.1\|613508_613958_+	DUF4314 domain-containing protein	A0A1X9I6A3	Streptococcus_phage	6.1e-16	62.1
WP_000290865.1\|614009_614483_+\|terminase	phage terminase small subunit P27 family	A0A1X9I6K0	Streptococcus_phage	2.3e-85	97.5
WP_000220984.1\|614479_616072_+\|terminase	terminase large subunit	A0A1X9I6B3	Streptococcus_phage	2.8e-305	95.1
WP_001166641.1\|616142_616400_+	type II toxin-antitoxin system Phd/YefM family antitoxin	E4ZFM1	Streptococcus_phage	1.2e-35	95.3
WP_001221830.1\|616396_616768_+	type II toxin-antitoxin system death-on-curing family toxin	A0A1X9I6C0	Streptococcus_phage	1.2e-57	89.4
WP_000149738.1\|616793_617120_+	hypothetical protein	NA	NA	NA	NA
WP_000523693.1\|617187_618477_+\|portal	phage portal protein	A0A1B0RXD8	Streptococcus_phage	2.2e-228	90.6
WP_001225240.1\|618469_619168_+\|protease	Clp protease ClpP	A0A1B0RXE1	Streptococcus_phage	1.0e-105	83.2
WP_050881953.1\|619181_620390_+\|capsid	phage major capsid protein	E4ZFM5	Streptococcus_phage	5.2e-211	90.8
WP_000987322.1\|620386_620644_+\|head,tail	phage gp6-like head-tail connector protein	D0R0D7	Streptococcus_phage	1.5e-27	74.1
WP_000705390.1\|620643_620982_+\|head,tail	head-tail adaptor protein	A0A1B0RXJ6	Streptococcus_phage	6.2e-37	66.1
WP_000161243.1\|620974_621343_+	hypothetical protein	Q6DMT7	Streptococcus_phage	1.1e-34	63.8
WP_001209973.1\|621351_621678_+	hypothetical protein	M1Q1Z4	Streptococcus_phage	1.6e-37	67.6
WP_000818566.1\|621680_622250_+\|tail	phage tail protein	E4ZFM9	Streptococcus_phage	1.6e-98	95.7
WP_001249615.1\|622261_622681_+	hypothetical protein	E4ZFN0	Streptococcus_phage	1.3e-55	74.8
WP_050265437.1\|622975_626095_+	hypothetical protein	Q6DMT2	Streptococcus_phage	3.0e-242	75.5
WP_000589858.1\|626091_626817_+	hypothetical protein	Q6DMT1	Streptococcus_phage	8.0e-82	57.9
WP_000966166.1\|626816_629732_+	hypothetical protein	Q6DMT0	Streptococcus_phage	0.0e+00	65.2
WP_000796402.1\|629744_631601_+	hypothetical protein	Q6DMS9	Streptococcus_phage	1.5e-257	73.4
WP_000661350.1\|631618_632017_+\|holin	phage holin family protein	D0R0E9	Streptococcus_phage	5.1e-38	60.8
WP_000123549.1\|633560_633668_+\|holin	putative holin-like toxin	NA	NA	NA	NA

DBSCAN-SWA_4

927667 : 992378

Streptococcus_phage(60.0%)

transposase,integrase

attL 928899:928958|attR 967988:968212

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000564846.1\|927667_928801_+\|transposase	ISAs1-like element IS1548 family transposase	NA	NA	NA	NA
928899:928958	attL	NA	NA	NA	NA
WP_151383509.1\|929223_930135_+	leucine-rich repeat domain-containing protein	NA	NA	NA	NA
WP_000180005.1\|930234_930894_+	HD domain-containing protein	S4W232	Pandoravirus	1.1e-08	26.6
WP_000621142.1\|930902_931367_+	GNAT family N-acetyltransferase	G5DEI8	Salmonella_phage	1.8e-07	35.7
WP_000665410.1\|931366_931801_+	peptide-methionine (R)-S-oxide reductase MsrB	NA	NA	NA	NA
WP_000168898.1\|931952_934745_+	cation-transporting P-type ATPase	M1HK51	Paramecium_bursaria_Chlorella_virus	7.1e-78	29.9
WP_000065321.1\|934744_935848_+	DUF2974 domain-containing protein	NA	NA	NA	NA
WP_000146565.1\|935968_936607_-	CatB-related O-acetyltransferase	A0A2R8FE91	Brazilian_cedratvirus	4.9e-19	43.4
WP_000564846.1\|937387_938521_-\|transposase	ISAs1-like element IS1548 family transposase	NA	NA	NA	NA
WP_001056394.1\|938642_939254_+	TVP38/TMEM64 family protein	M1Q152	Streptococcus_phage	2.7e-54	54.9
WP_001291561.1\|939427_940645_-\|integrase	tyrosine-type recombinase/integrase	A0A1S5SEW7	Streptococcus_phage	3.7e-233	100.0
WP_000814511.1\|940726_940930_-	excisionase	A0A1S5SF07	Streptococcus_phage	4.0e-31	100.0
WP_000857133.1\|941390_941621_-	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	2.7e-36	100.0
WP_000804885.1\|941617_942040_-	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	2.5e-72	100.0
WP_001227346.1\|942544_942898_+	helix-turn-helix transcriptional regulator	A0A1S5SFA6	Streptococcus_phage	2.3e-58	99.1
WP_000336323.1\|942957_943125_-	conjugal transfer protein	D0R0F6	Streptococcus_phage	1.6e-14	68.0
WP_000691727.1\|943243_945163_-	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	100.0
WP_001791010.1\|945178_945295_-	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_001224319.1\|945539_946472_-	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	1.1e-171	100.0
WP_000769868.1\|946468_947470_-	peptidase P60	A0A1S5SEZ8	Streptococcus_phage	5.0e-191	100.0
WP_000331160.1\|949646_952094_-	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	100.0
WP_000506270.1\|952077_952584_-	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	8.6e-91	100.0
WP_000342539.1\|952558_953056_-	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.7e-91	100.0
WP_001009056.1\|953172_953394_-	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.3e-31	100.0
WP_000398284.1\|953436_954642_-	XRE family transcriptional regulator	A0A1S5SEX3	Streptococcus_phage	2.8e-233	100.0
WP_000879507.1\|954664_954817_-	hypothetical protein	NA	NA	NA	NA
WP_000813488.1\|954819_956205_-	DNA translocase FtsK	A0A1S5SFB5	Streptococcus_phage	1.1e-265	100.0
WP_000985015.1\|956233_956620_-	YdcP family protein	A0A1S5SF96	Streptococcus_phage	3.0e-64	100.0
WP_000420682.1\|956635_956950_-	YdcP family protein	A0A1S5SF38	Streptococcus_phage	5.2e-54	100.0
WP_000467138.1\|957330_958113_-	hypothetical protein	NA	NA	NA	NA
WP_000192686.1\|958124_958823_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	3.2e-19	26.6
WP_000312256.1\|958823_959192_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_050881970.1\|959336_962441_+	DNA polymerase III subunit alpha	A0A0K1Y8J9	Streptomyces_phage	3.1e-114	28.8
WP_000820831.1\|962521_963544_+	6-phosphofructokinase	NA	NA	NA	NA
WP_001042781.1\|963592_965095_+	pyruvate kinase	NA	NA	NA	NA
WP_000240773.1\|965265_965823_+	signal peptidase I	NA	NA	NA	NA
WP_000334314.1\|966091_967906_+	glutamine--fructose-6-phosphate transaminase (isomerizing)	Q76DQ7	Chlorella_virus	6.4e-96	36.9
WP_000564846.1\|968082_969216_+\|transposase	ISAs1-like element IS1548 family transposase	NA	NA	NA	NA
967988:968212	attR	NA	NA	NA	NA
WP_000056777.1\|969394_969724_+	alkylphosphonate utilization protein	NA	NA	NA	NA
WP_000120401.1\|969858_970500_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_000891276.1\|970509_971139_+	amino acid ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	5.6e-31	38.3
WP_000955380.1\|971152_971986_+	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001872296.1\|972069_972318_-	30S ribosomal protein S20	NA	NA	NA	NA
WP_001058331.1\|972371_973292_-	type I pantothenate kinase	A0A1B1ISL9	uncultured_Mediterranean_phage	1.1e-32	35.6
WP_050881971.1\|973397_973988_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_000526762.1\|974313_974703_+	cytidine deaminase	NA	NA	NA	NA
WP_001034779.1\|974767_975817_+	BMP family ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000193235.1\|975961_977497_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-23	31.9
WP_000060306.1\|978552_979509_+	ABC transporter permease	NA	NA	NA	NA
WP_000036813.1\|979713_981084_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_000127487.1\|981204_982194_-	L-lactate dehydrogenase	NA	NA	NA	NA
WP_017644318.1\|982432_984892_+	DNA gyrase subunit A	G3M9Z5	Bacillus_virus	8.7e-104	34.2
WP_050881973.1\|984898_985642_+	sortase	NA	NA	NA	NA
WP_000767937.1\|985657_986071_+	VOC family protein	NA	NA	NA	NA
WP_000023418.1\|986223_987186_+	DUF1002 domain-containing protein	NA	NA	NA	NA
WP_000547446.1\|987248_988376_-	cation:proton antiporter	NA	NA	NA	NA
WP_088181596.1\|988635_989440_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_000129872.1\|989506_991069_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	4.9e-20	31.7
WP_000564846.1\|991244_992378_-\|transposase	ISAs1-like element IS1548 family transposase	NA	NA	NA	NA

DBSCAN-SWA_5

1183287 : 1246329

Indivirus(12.5%)

transposase,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001259491.1\|1183287_1183998_-\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_000863788.1\|1184087_1184876_-	esterase family protein	NA	NA	NA	NA
WP_001280077.1\|1184932_1186594_-	ribonuclease J	NA	NA	NA	NA
WP_000564846.1\|1186949_1188083_-\|transposase	ISAs1-like element IS1548 family transposase	NA	NA	NA	NA
WP_032455167.1\|1188217_1188976_-	ATP-binding cassette domain-containing protein	A0A1V0SE00	Indivirus	4.1e-12	29.3
WP_000587303.1\|1188978_1189842_-	ABC transporter permease	NA	NA	NA	NA
WP_000790858.1\|1189854_1190859_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000006719.1\|1191216_1192872_+	fibronectin/fibrinogen-binding protein	A0A1J0F9J4	Only_Syngen_Nebraska_virus	2.3e-07	41.0
WP_000005484.1\|1192925_1193645_-	acetolactate decarboxylase	NA	NA	NA	NA
WP_000140348.1\|1193658_1195341_-	acetolactate synthase AlsS	NA	NA	NA	NA
WP_000934876.1\|1195450_1196677_-	hypothetical protein	NA	NA	NA	NA
WP_001081539.1\|1196666_1197857_-	AI-2E family transporter	NA	NA	NA	NA
WP_000796045.1\|1197948_1198410_-	NUDIX hydrolase	NA	NA	NA	NA
WP_000163516.1\|1198399_1198882_-	8-oxo-dGTP diphosphatase	NA	NA	NA	NA
WP_000564846.1\|1200457_1201591_+\|transposase	ISAs1-like element IS1548 family transposase	NA	NA	NA	NA
WP_000277598.1\|1203694_1204735_-	dTDP-glucose 4,6-dehydratase	A0A1D7XFE8	Escherichia_phage	9.4e-68	43.6
WP_000459888.1\|1204786_1205299_-	hypothetical protein	NA	NA	NA	NA
WP_000139165.1\|1205298_1205892_-	dTDP-4-dehydrorhamnose 3,5-epimerase family protein	NA	NA	NA	NA
WP_000676113.1\|1205891_1206761_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	3.5e-100	61.8
WP_000716841.1\|1206819_1207923_-	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_000647414.1\|1207931_1208720_-	Nif3-like dinuclear metal center hexameric protein	NA	NA	NA	NA
WP_000365677.1\|1208709_1209393_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_000221657.1\|1209496_1210177_-	DnaD domain-containing protein	Q938N2	Temperate_phage	1.9e-08	31.8
WP_000365343.1\|1210294_1210813_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	4.6e-31	44.1
WP_000564797.1\|1210994_1212128_-\|transposase	ISAs1-like element IS1548 family transposase	NA	NA	NA	NA
WP_001247524.1\|1212261_1214826_-	hypothetical protein	NA	NA	NA	NA
WP_000622242.1\|1214977_1217176_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	1.2e-72	28.9
WP_050881983.1\|1217172_1217934_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_000405387.1\|1217935_1218865_-	ribonuclease Z	NA	NA	NA	NA
WP_000568323.1\|1218906_1219554_-	cystathionine beta-lyase	NA	NA	NA	NA
WP_000573350.1\|1219546_1220785_-	GTPase HflX	NA	NA	NA	NA
WP_001226482.1\|1220875_1221766_-\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_000239229.1\|1221876_1222053_+	DUF3042 family protein	NA	NA	NA	NA
WP_050265453.1\|1223146_1226905_-	pullulanase	NA	NA	NA	NA
WP_000130593.1\|1227821_1228406_-	uracil-DNA glycosylase family protein	NA	NA	NA	NA
WP_000150956.1\|1228502_1229909_-	dipeptidase PepV	NA	NA	NA	NA
WP_000670191.1\|1229955_1230558_-	NAD(P)H nitroreductase	NA	NA	NA	NA
WP_001003961.1\|1232550_1234332_-	excinuclease ABC subunit UvrC	NA	NA	NA	NA
WP_000567584.1\|1234490_1235258_+	epoxyqueuosine reductase QueH	NA	NA	NA	NA
WP_000285038.1\|1235316_1236657_-	MATE family efflux transporter	NA	NA	NA	NA
WP_000245056.1\|1236756_1237173_-	VOC family protein	NA	NA	NA	NA
WP_000582587.1\|1237176_1237674_-	hypothetical protein	NA	NA	NA	NA
WP_000162276.1\|1237895_1238492_+	Lj965 prophage superinfection immunity protein	NA	NA	NA	NA
WP_088196775.1\|1238680_1239785_+\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	1.4e-69	49.3
WP_000754576.1\|1241614_1244086_-	pneumococcal-type histidine triad protein	NA	NA	NA	NA
WP_000715197.1\|1244098_1245019_-	metal ABC transporter substrate-binding lipoprotein/laminin-binding adhesin Lmb	NA	NA	NA	NA
WP_000564846.1\|1245195_1246329_-\|transposase	ISAs1-like element IS1548 family transposase	NA	NA	NA	NA

DBSCAN-SWA_6

1264168 : 1284536

Streptococcus_phage(92.31%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000086364.1\|1264168_1266298_-	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	0.0e+00	99.7
WP_000592531.1\|1266290_1266659_-	helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	1.4e-63	100.0
WP_001072464.1\|1266861_1267161_+	hypothetical protein	Q6DMX6	Streptococcus_phage	5.3e-48	96.0
WP_000540327.1\|1267214_1268003_-	hypothetical protein	NA	NA	NA	NA
WP_000934381.1\|1268011_1268608_+	TIGR01906 family membrane protein	NA	NA	NA	NA
WP_050881986.1\|1268781_1270869_-	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	2.2e-60	29.9
WP_000711500.1\|1271007_1271214_-	copper chaperone TcrZ	NA	NA	NA	NA
WP_000103845.1\|1271824_1272271_-	CopY/TcrY family copper transport repressor	NA	NA	NA	NA
WP_000711078.1\|1272728_1273067_-	Cd(II)/Zn(II)-sensing metalloregulatory transcriptional regulator CadX	E4ZFI8	Streptococcus_phage	1.7e-10	33.3
WP_000615743.1\|1273079_1273694_-	CadD family cadmium resistance transporter	NA	NA	NA	NA
WP_000756015.1\|1273767_1275330_-	recombinase family protein	Q6DMS5	Streptococcus_phage	3.2e-213	71.7
WP_050265449.1\|1275329_1276241_-	recombinase family protein	M1NSJ1	Streptococcus_phage	3.6e-156	95.8
WP_000515884.1\|1276626_1278096_-	LysM peptidoglycan-binding domain-containing protein	A0A1X9I678	Streptococcus_phage	3.5e-262	92.8
WP_000661395.1\|1278102_1278498_-\|holin	phage holin family protein	A0A1B0RXK5	Streptococcus_phage	3.2e-45	99.2
WP_000922387.1\|1278475_1278682_-	hypothetical protein	A0A1B0RXE8	Streptococcus_phage	1.5e-14	92.5
WP_001058366.1\|1279318_1279678_+	winged helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	2.7e-22	47.3
WP_001291323.1\|1279674_1281792_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	3.1e-235	62.7
WP_001875682.1\|1282494_1282725_+	CHAP domain-containing protein	NA	NA	NA	NA
WP_000490874.1\|1282837_1283608_-	ABC transporter permease	NA	NA	NA	NA
WP_000119359.1\|1283600_1284536_-	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	5.2e-25	31.6

DBSCAN-SWA_7

1615103 : 1626621

Streptococcus_phage(90.91%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000767484.1\|1615103_1615931_+	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	4.3e-124	78.0
WP_000287944.1\|1615970_1616327_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.5e-41	71.8
WP_000966773.1\|1616328_1616805_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.0e-37	50.3
WP_000232156.1\|1616859_1618041_-	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	7.0e-168	75.6
WP_001167085.1\|1618103_1618652_-	acetyltransferase	M1PSC3	Streptococcus_phage	1.1e-54	58.4
WP_000603277.1\|1619944_1620580_+	copper homeostasis protein CutC	NA	NA	NA	NA
WP_000425856.1\|1620849_1621719_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	4.9e-110	70.4
WP_000358198.1\|1621718_1622045_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	3.2e-30	61.1
WP_000364565.1\|1622074_1622938_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	7.3e-74	49.7
WP_000715592.1\|1622957_1623593_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.8e-67	61.1
WP_000160532.1\|1623801_1624968_+\|transposase	IS30-like element ISSag9 family transposase	NA	NA	NA	NA
WP_050265419.1\|1625232_1625892_-	CBS domain-containing protein	M1NSC5	Streptococcus_phage	1.5e-63	55.1
WP_000178146.1\|1625910_1626621_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.7e-18	28.5

DBSCAN-SWA_8

2116785 : 2123989

uncultured_Caudovirales_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001042655.1\|2116785_2117490_-	transglycosylase SLT domain-containing protein	A0A2H4J6C5	uncultured_Caudovirales_phage	4.2e-27	56.6
WP_000029068.1\|2117595_2118135_-	LysM peptidoglycan-binding domain-containing protein	A0A249XZV3	Enterococcus_phage	6.7e-17	45.8
WP_000359358.1\|2118350_2119145_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_000510606.1\|2119137_2119980_-	energy-coupling factor transporter ATPase	A0A2H4PQG7	Staphylococcus_phage	2.0e-15	28.5
WP_000181757.1\|2119955_2120795_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	3.5e-20	30.0
WP_000976003.1\|2120794_2121337_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_000217754.1\|2121459_2122743_-	insulinase family protein	A0A2H4UVM3	Bodo_saltans_virus	2.2e-05	23.6
WP_000706188.1\|2122744_2123989_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	3.7e-87	41.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP011329

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection