CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP012067	Aggregatibacter aphrophilus strain W10433 chromosome, complete genome	2 crisprs	cas3,cas5,cas8c,cas7,cas4,cas1,cas2,WYL,DEDDh,DinG	1	2	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012067_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012067_1

1316635-1317397

TypeI

Consensus_repeat	Method
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	PILER-CR
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	CRISPRCasFinder
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	CRT

11 spacers

cas2,cas1,cas4,cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_CP012067_1

>merge|NZ_CP012067|1|1316635-1317397|PILER-CR,CRISPRCasFinder,CRT
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAACCCGACCGCACTTTGCGCTGATGTTCGTGTAACACGGCGCAGCCGCCTTCGGGCGGCTGTGTGTTGAAACCTCTTAGTTAAGTTAATCAAGCAACAAAGCGTAAAGCAGCCGCCTTCGGGCGGCTGTGTGTTGAAACCATCTCTATCATAAGTTACAGCCCCCAAAATAGGCGCAGCCGCCTTCGGGCGGCTGTGTGTTGAAACAGGTGTTGGGGAGCAAAATGAAAGCATATCGTTTGCAGCCGCCTTCGGGCGGCTGTGTGTTGAAACTCCAAAAAATAGCGGGCTATGTAACAACAGTGGCGCAGCCGCCTTCGGGCGGCTGTGTGTTGAAACACTGGCCGCCGTCAGCTTACGACGGAATGACATTGCAGCCGCCTTCGGGCGGCTGTGTGTTGAAACGATAAAAATCGTGCCTGGTATTAATCGGGCATCTGCAGCCGCCTTCGGGCGGCTGTGTGTTGAAACGTCAGTAATTCGCAATTGTCCGACTAGCGAAACTGCAGCCACCTTCGGGTGGCTGTGTGTTGAAACCTCGATGCCGTGCGTCCAGTTGTGCGCGCCTATGCAGCCGCCTCCGCGCGGCTGTGTGTTGAAACGATTTCGACGTAACCAATTCCTAACCGCTTAAAAGCAGCCGCCTCCGCGCGGCTGTGTGTTGAAACAAGCCCCGCCGCTTGCGTCAAAATAAGATTTGTCGGCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC

>NZ_CP012067|1|1|1316635-1317397|PILER-CR
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	CCGACCGCACTTTGCGCTGATGTTCGTGTAACACGGC
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	CTCTTAGTTAAGTTAATCAAGCAACAAAGCGTAAA
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	CATCTCTATCATAAGTTACAGCCCCCAAAATAGGC
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	AGGTGTTGGGGAGCAAAATGAAAGCATATCGTTT
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	TCCAAAAAATAGCGGGCTATGTAACAACAGTGGC
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	ACTGGCCGCCGTCAGCTTACGACGGAATGACATT
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	GATAAAAATCGTGCCTGGTATTAATCGGGCATCT
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	GTCAGTAATTCGCAATTGTCCGACTAGCGAAACT
GCAGCCACCTTCGGGTGGCTGTGTGTTGAAAC	CTCGATGCCGTGCGTCCAGTTGTGCGCGCCTAT
GCAGCCGCCTCCGCGCGGCTGTGTGTTGAAAC	GATTTCGACGTAACCAATTCCTAACCGCTTAAAA
GCAGCCGCCTCCGCGCGGCTGTGTGTTGAAAC	AAGCCCCGCCGCTTGCGTCAAAATAAGATTTGTCG
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC

>NZ_CP012067|1|1|1316635-1317397|CRISPRCasFinder
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	CCGACCGCACTTTGCGCTGATGTTCGTGTAACACGGC
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	CTCTTAGTTAAGTTAATCAAGCAACAAAGCGTAAA
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	CATCTCTATCATAAGTTACAGCCCCCAAAATAGGC
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	AGGTGTTGGGGAGCAAAATGAAAGCATATCGTTT
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	TCCAAAAAATAGCGGGCTATGTAACAACAGTGGC
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	ACTGGCCGCCGTCAGCTTACGACGGAATGACATT
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	GATAAAAATCGTGCCTGGTATTAATCGGGCATCT
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	GTCAGTAATTCGCAATTGTCCGACTAGCGAAACT
GCAGCCACCTTCGGGTGGCTGTGTGTTGAAAC	CTCGATGCCGTGCGTCCAGTTGTGCGCGCCTAT
GCAGCCGCCTCCGCGCGGCTGTGTGTTGAAAC	GATTTCGACGTAACCAATTCCTAACCGCTTAAAA
GCAGCCGCCTCCGCGCGGCTGTGTGTTGAAAC	AAGCCCCGCCGCTTGCGTCAAAATAAGATTTGTCG
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC

>NZ_CP012067|1|1|1316635-1317397|CRT
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	CCGACCGCACTTTGCGCTGATGTTCGTGTAACACGGC
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	CTCTTAGTTAAGTTAATCAAGCAACAAAGCGTAAA
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	CATCTCTATCATAAGTTACAGCCCCCAAAATAGGC
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	AGGTGTTGGGGAGCAAAATGAAAGCATATCGTTT
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	TCCAAAAAATAGCGGGCTATGTAACAACAGTGGC
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	ACTGGCCGCCGTCAGCTTACGACGGAATGACATT
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	GATAAAAATCGTGCCTGGTATTAATCGGGCATCT
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC	GTCAGTAATTCGCAATTGTCCGACTAGCGAAACT
GCAGCCACCTTCGGGTGGCTGTGTGTTGAAAC	CTCGATGCCGTGCGTCCAGTTGTGCGCGCCTAT
GCAGCCGCCTCCGCGCGGCTGTGTGTTGAAAC	GATTTCGACGTAACCAATTCCTAACCGCTTAAAA
GCAGCCGCCTCCGCGCGGCTGTGTGTTGAAAC	AAGCCCCGCCGCTTGCGTCAAAATAAGATTTGTCG
GCAGCCGCCTTCGGGCGGCTGTGTGTTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012067.1\|WP_050332750.1\|1328414_1329146_+\|branched-chain-amino-acid-transporter-AzlC	unknown	unknown	gnl\|CDD\|129446
NZ_CP012067.1\|WP_012771286.1\|1319314_1320106_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197313
NZ_CP012067.1\|WP_050693398.1\|1304207_1306499_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NZ_CP012067.1\|WP_050693402.1\|1310183_1311962_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|187887
NZ_CP012067.1\|WP_050693407.1\|1317639_1319304_-\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|131058
NZ_CP012067.1\|WP_050693403.1\|1311973_1312840_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl\|CDD\|377458
NZ_CP012067.1\|WP_050693408.1\|1324086_1324800_+\|UTRA-domain-containing-protein	unknown	unknown	gnl\|CDD\|274116
NZ_CP012067.1\|WP_080988250.1\|1327338_1327479_-\|transcriptional-regulator	unknown	unknown	unknown
NZ_CP012067.1\|WP_005702619.1\|1316149_1316443_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP012067.1\|WP_050693409.1\|1324939_1327213_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|235367
NZ_CP012067.1\|WP_050693411.1\|1329142_1329472_+\|branched-chain-amino-acid-ABC-transporter	unknown	unknown	gnl\|CDD\|224601
NZ_CP012067.1\|WP_050693404.1\|1312934_1313585_+\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NZ_CP012067.1\|WP_050693406.1\|1315132_1316146_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NZ_CP012067.1\|WP_050693405.1\|1313648_1315100_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224117
NZ_CP012067.1\|WP_050693410.1\|1327477_1328410_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176132
NZ_CP012067.1\|WP_080988249.1\|1320115_1323889_-\|4-alpha-glucanotransferase	unknown	unknown	gnl\|CDD\|340853
NZ_CP012067.1\|WP_050693401.1\|1309512_1310187_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|187534
NZ_CP012067.1\|WP_050693400.1\|1307644_1309390_+\|DUF87-domain-containing-protein	unknown	unknown	gnl\|CDD\|376671
NZ_CP012067.1\|WP_050693399.1\|1306605_1307655_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238697
NZ_CP012067.1\|WP_050694186.1\|1329630_1330479_+\|DUF535-domain-containing-protein	unknown	unknown	gnl\|CDD\|377343

Protein	Function_ID	Function_description	E-value
NZ_CP012067.1\|WP_050332750.1\|1328414_1329146_+\|branched-chain-amino-acid-transporter-AzlC	gnl\|CDD\|129446	TIGR00346, Uncharacterized_membrane_protein_HI_1738, 4-azaleucine resistance probable transporter AzlC. Overexpression of this gene results in resistance to a leucine analog, 4-azaleucine. The protein has 5 potential transmembrane motifs. It has been inferred, but not experimentally demonstrated, to be part of a branched-chain amino acid transport system. Commonly found in association with azlD. [Transport and binding proteins, Amino acids, peptides and amines].	5.2473e-97
NZ_CP012067.1\|WP_012771286.1\|1319314_1320106_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197313	cd09079, RgfB-like, Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins. This family includes Streptococcus agalactiae RgfB (for regulator of fibrinogen binding) and related proteins. The function of RgfB is unknown. It is part of a putative two component signal transduction system designated rgfBDAC (the rgf locus was identified in a screen for mutants of Streptococcus agalactiae with altered binding to fibrinogen). RgfA,-C,and -D do not belong to this superfamily: rgfA encodes a putative response regulator, and rgfC, a putative histidine kinase. All four genes are co-transcribed, and may be involved in regulating expression of bacterial cell surface components. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.	1.72838e-124
NZ_CP012067.1\|WP_050693398.1\|1304207_1306499_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	1.08179e-56
NZ_CP012067.1\|WP_050693402.1\|1310183_1311962_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	0
NZ_CP012067.1\|WP_050693407.1\|1317639_1319304_-\|PTS-transporter-subunit-EIIC	gnl\|CDD\|131058	TIGR02003, PTS_system_glucose-specific_IIBC_component, PTS system, IIBC component. This model represents a family of fused B and C components of PTS enzyme II. This clade is a member of a larger family which contains enzyme II's specific for a variety of sugars including glucose (TIGR02002) and N-acetylglucosamine (TIGR01998). None of the members of this clade have been experimentally characterized. This clade includes sequences from Streptococcus and Enterococcus which also include a C-terminal A domain as well as Bacillus and Clostridium which do not. In nearly all cases, these species also contain an authentic glucose-specific PTS transporter. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NZ_CP012067.1\|WP_050693403.1\|1311973_1312840_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	2.48447e-152
NZ_CP012067.1\|WP_050693408.1\|1324086_1324800_+\|UTRA-domain-containing-protein	gnl\|CDD\|274116	TIGR02404, Trehalose_operon_transcriptional_repressor, trehalose operon repressor, B. subtilis-type. This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions].	1.07439e-60
NZ_CP012067.1\|WP_005702619.1\|1316149_1316443_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.82432e-30
NZ_CP012067.1\|WP_050693409.1\|1324939_1327213_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	gnl\|CDD\|235367	PRK05222, PRK05222, 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional.	0
NZ_CP012067.1\|WP_050693411.1\|1329142_1329472_+\|branched-chain-amino-acid-ABC-transporter	gnl\|CDD\|224601	COG1687, AzlD, Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism].	1.14212e-39
NZ_CP012067.1\|WP_050693404.1\|1312934_1313585_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	1.38769e-43
NZ_CP012067.1\|WP_050693406.1\|1315132_1316146_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NZ_CP012067.1\|WP_050693405.1\|1313648_1315100_+\|hypothetical-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	6.33138e-08
NZ_CP012067.1\|WP_050693410.1\|1327477_1328410_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176132	cd08441, PBP2_MetR, The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold. MetR, a member of the LysR family, is a positive regulator for the metA, metE, metF, and metH genes. The sulfur-containing amino acid methionine is the universal initiator of protein synthesis in all known organisms and its derivative S-adenosylmethionine (SAM) and autoinducer-2 (AI-2) are involved in various cellular processes. SAM plays a central role as methyl donor in methylation reactions, which are essential for the biosynthesis of phospholipids, proteins, DNA and RNA. The interspecies signaling molecule AI-2 is involved in cell-cell communication process (quorum sensing) and gene regulation in bacteria. Although methionine biosynthetic enzymes and metabolic pathways are well conserved in bacteria, the regulation of methionine biosynthesis involves various regulatory mechanisms. In Escherichia coli and Salmonella enterica serovar Typhimurium, MetJ and MetR regulate the expression of methionine biosynthetic genes. The MetJ repressor negatively regulates the E. coli met genes, except for metH. Several of these genes are also under the positive control of MetR with homocysteine as a co-inducer. In Bacillus subtilis, the met genes are controlled by S-box termination-antitermination system. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.25769e-107
NZ_CP012067.1\|WP_080988249.1\|1320115_1323889_-\|4-alpha-glucanotransferase	gnl\|CDD\|340853	cd04300, GT35_Glycogen_Phosphorylase, glycogen phosphorylase and similar proteins. This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism. The allosteric control mechanisms of yeast and mammalian members of this family are different from that of bacterial members. The members of this family belong to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	0
NZ_CP012067.1\|WP_050693401.1\|1309512_1310187_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	2.30138e-118
NZ_CP012067.1\|WP_050693400.1\|1307644_1309390_+\|DUF87-domain-containing-protein	gnl\|CDD\|376671	pfam01935, DUF87, Domain of unknown function DUF87. The function of this prokaryotic domain is unknown. It contains several conserved aspartates and histidines that could be metal ligands.	3.05543e-28
NZ_CP012067.1\|WP_050693399.1\|1306605_1307655_+\|hypothetical-protein	gnl\|CDD\|238697	cd01406, SIR2-like, Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.	3.33048e-07
NZ_CP012067.1\|WP_050694186.1\|1329630_1330479_+\|DUF535-domain-containing-protein	gnl\|CDD\|377343	pfam04393, DUF535, Protein of unknown function (DUF535). Family member Shigella flexneri VirK is a virulence protein required for the expression, or correct membrane localization of IcsA (VirG) on the bacterial cell surface,. This family also includes Pasteurella haemolytica lapB, which is thought to be membrane-associated.	1.55088e-101

>NZ_CP012067.1|WP_005702619.1|1316149_1316443_+|CRISPR-associated-endonuclease-Cas2
MLMLITYDISFDDPNGQARLRRIAKHCLDYGVRAQYSVFECDVTPDQWVMLKNKLLETYDPTCDSLRFYHLGSKWRNKVEHHGAKPAVDVFKDVLVI
>NZ_CP012067.1|WP_050693406.1|1315132_1316146_+|type-I-C-CRISPR-associated-endonuclease-Cas1
MRKLQNTLYITTQGSYLHKERETLVVEQERKKVAQLPVHSIGHIFCFGNVLVSPFLLGFCGENNVNLAFFTENGRYLGRLQGRQSGNVLLRRAQYRVSEQNPVPIARNIIAAKIQASKRVLQRQIRNYGENATIQSAVDALNISLRQLKGAAELDLVRGIEGDAAARYFGVFGQLLSEKSGFTFDGRNRRPPRDGVNALLSFVYSILGKDISGALQGVGLDPQVGFLHADRPGRDSLAQDILEEFRAWWVDRLVLSLINRGQIKPQDFVTETSGAVSLKADARKLLFQALQAKKQEKIVHPFLDEEVEIGLLPYIQAMLLARHLRGDLAEYPPFLMR
>NZ_CP012067.1|WP_050693405.1|1313648_1315100_+|hypothetical-protein
MSLKIDKFNDEIIPLWNEVQNIINEIDEKLVSDSYIEKFAYLRKITAFLSEAMSCIDADFLPDTFLDNIKSYLSNMRSYLVNTRDYTNLSYISYTEDCLDGLLQIVFPFILHKGKAIKGLRIGLNEYLKTINAHVENEFSEIKSIHESANEIKTELKNELDEFEALRTEIEEYRDLIFSADGVKKNIENLLKSSESKLSEIEKLHNSIYEEDGLKQEIDEFYSNISDKNREINELKEDSSTTLQGLSNFYDKIFGKDDENGKKVGGLKQEIDQRRSDLDEFKQKQEERYNELNKQIENLLPGATSAGLSSAYSEMRNKFSKNAKWYGIGFYFSLCVLLITVLCIRDVMLVGDIPLDKGIWISLLVLLGNFAVKMPFIIPALWLVIFISRRRSEAERLSQEYAHKEVLAKSYDSYKQQIEKLSKKEQEELLPVLMEGMIKAISLNPAETLDKKHQSDSPISEVLKDKKFIDSIVDKIKGSSSKS
>NZ_CP012067.1|WP_050693404.1|1312934_1313585_+|CRISPR-associated-protein-Cas4
MTALLTETQGENQDTRLIPLSALQHYAFCPRQCALIHNEQAWAENYLTAQGKALHERVDSGEPETRKGVRFERTVHVSAEKLGISGVLDLVEVETKTGRLKPVEYKRGKPKPDPMDEIQLCAQGLCLEEMTGQTVSEGALWYMQTRHRVPVVFSDDLRAQTLATIAAVRELLNSGQTPSPNYGKRCKACSLVEICQPELLGKRDRSVVYVVGLFGE
>NZ_CP012067.1|WP_050693403.1|1311973_1312840_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSAIQNRYEFVYFFDVTNGNPNGDPDAGNMPRLDPESSKGLVTDVCLKRKIRNFVEISSENEAGYEIYVKEKSVLNLQNKRAYEALGIESEAKKLPKDEAKARDITAWMCKNFFDIRTFGAVMTTEVNSGQVRGPVQLAFAQSIDPIVPLEVSITRMAVTNEKDLEKERTMGRKYIVPYALYRVHGFISANLAAKTGFSDDDLAKLWQALTLMFEHDRSAARGEMAARKLIVFKHDSALGSQPAHKLFDAVKVERVNGESGTPASGFGDYNISVVSDDLNGVSVEELL
>NZ_CP012067.1|WP_050693402.1|1310183_1311962_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MILASLARYYRRLAAETDDMGNPKVPPYGFSEEKIGWILVLDKEGRLKTAVPNLTADKKPQPKLMSVPRPEKRTSGIKPNFLWDKTAYALGVEANKNKAEAKEKPFTSSEKTFDAFKQYHLDLLQNSKDEGLQALCRFLQNWQPAHFAAENLPAEMLDANIAFSLEKPTALIHKREAAQTLWAGCLKSDEALEGLCLISGDTAPIARLHPAIKGVFGGQSSGGSIISFNKEAFASFGKEQGANAPVSEQSAFAYTTALNYLLRRENNHCLTIGDASTVFWAEADDNATAQAAEGFFAHVFTPPDDEQESAKVFNVLEQIGKGRPLQEIAPELSPNTRFYILGLAPNAARISVRFWLDTTFGQLAENLAQHWQDLALEPCAWKTPPSIWRLLLQTAVLGKSENISPVLAGEMTRAVICGTPYPLSLLSQLITRICADGDVNGLRVAMMKAVLERRFRKGFIEEGVPMSLNNESPNRAYLLGRLFAVLERIQYQALGELNAGIADRYYGSASAVPFSVFPRLLSGAKHHLSRLRKDKAGMAVNLDKDLGEIIAKLPETFPHHLSIDEQGRFAIGYYHQKQSYFAKKETAETIEN
>NZ_CP012067.1|WP_050693401.1|1309512_1310187_+|type-I-C-CRISPR-associated-protein-Cas5
MNQIRLHVWGDYACFTRPEMKVERVSYDVITPSAARGILAAVHWKPAIRWVIDRIYVLKPIRFESVRRNELGGKISAGKVSGAMKRKSVADLYTLIEDDRQQRAATVLKDVAYVIEAHAVLTAKAGADETVTKHIEMFKRRAKKGQCFQQPCLGVREFPADFALIDEDEPLPLSALVESEANRDLGWMLHDIDFDHGNTPHFFRAQMKDGVIDVPPFYAEEVKA
>NZ_CP012067.1|WP_050693400.1|1307644_1309390_+|DUF87-domain-containing-protein
MEIKKLNFDAKDQLGRVVTVDTSRVLISVEEHEQMTSIAVGNLIAINGRTANEFLIGIIERVTRSISEKLLLDDTSDDGSIPLGESQDDFIRAVLIGTYRTVDGSLSNTFKRGADCFPQIDKTCFHLSGSNLQLFMNLLSANVAENERLTLGHFMADETAVAVANGDKFFQRHAAILGSTGSGKSWSVALILERAAALKSANLIVFDMHGEYSTLCEGENPIAQQYHIAGPGDLDGSNPNSLFIPYWLLNREEMLALILDRSDDNAPNQAARFTEHVRTLKEQTLQSEGKTEVLETFTVDSPIPYNINSLLEYLNRDDTGMKQGARGEVKGDWNGRLTRFIGRLKAKIDDRRCGFMFQPPKECNAYGWLENMLMKLFAVSESQRGIKIIDFSEVPSDVLPIITGVLARLLYNIQFWMDKDARHPLTIVCDEAHLYLPVRDAAEAAEKRALEAFERIAKEGRKYGVSLLVVSQRPSDVSRTILSQCNNFLVLRLTNDQDQSVVKRLLLESMVGITDILPLLDLGEALLLGDSILLPTRIKLDTPKIAPESATRQFWSDWANQEPKPDAVSKAVEALRRQVRT
>NZ_CP012067.1|WP_050693399.1|1306605_1307655_+|hypothetical-protein
MNNTELDDLKRWLQTIFTDKLVIIVGSGLSCAEGLPSMWHLGKKLKQEMPSKISNENLKIWNEIAACLESDGLEGALLKHPANDAIESVIIKITAEYVLNEEQKAINKCISENKKLKFSYLFPHISSCTPKMVRVITTNYDRLIEFAAEYEDWGVDSMMVGRYWGKHNPNLSEKLLVEKVVAKGKTPRLVYRNHIKIYKPHGSLDWFMAGNTPMTRCIGAMEEPLIITPGVGKYKKGYGQPFDVHREQGNRAIDSASAILCIGYGFNDDHLQTHLTTKIKSGIKTLILTRGLSDNARKVVCESSNCKALIFNENPRGTAVISNSGEEIISNVDWWDIEYFVKEVLENGN
>NZ_CP012067.1|WP_050693398.1|1304207_1306499_+|CRISPR-associated-helicase/endonuclease-Cas3
MSQSVIRYAHSAQDKLGNLLPYEHWQTLQSHSVNVGEMAAEFAQVFGAQEIACQTGKLHDLGKYSEAFNHRLHGGPSVDHATAGAKIAVERWGNVIGKLIAFCIAGHHAGLANGSGEGDNRRTLKDRLALQFGTDIPALDNLWQQEIKLPQNLSAPPLKADAHHPFFSYAFFTRMLYSCLVDADYLDTEAFYLKLENKASERGGYPKLNALQHNFNQFINKFRRRVAQAPAQTEAEKRNASLNCLRSEILEHAVEQAAQAQGLFTLTVPTGGGKTFTSMAFALEHAKRHGMRRVIYVIPFTSIIEQNAAEFRKAFGELGEQAVLEHHSTFDDGKLQGEATKDKLRLASENWDAPIVVTTAVQFFESLFADRSSRCRKLHNIAGSVIILDEAQMLPLNLLLPIMQAIKELAQNYRCSVVMCTATQPAVQAENGFYRGFENVREIAPKPTALFDKLRRTTVQHIGTQTDADLLAKLGEHPQMLVIVNNRRHARSLYDQAKHLDGTFHLTTLMCAKHRSQKLDEIRGRLKNGEPCRVIATSLIEAGVDVDFPLVMRAEAGLDSVAQAAGRCNREGKRPSENSFVWVFTPEEQWKAPPELTAQAAVMRLTADSFSDDLLSTQAVAAYFKDLYELKGKELDYKQILQMHHNAGQSLDFPFQTIADKFRMIESHMQPLIIPFDVDAENLISSLHHADHIGGLLRKLQPYTVQIPEKALAALYKAGRIEPINEKNFGKQFYTLIGLDLYDEVAGLSWEDVEFLKGESLVF
>NZ_CP012067.1|WP_050693407.1|1317639_1319304_-|PTS-transporter-subunit-EIIC
MKKLLSFEFWQKFGKCLMVVIAVMPAAGLMVSIGNSLPLISDAEWLARMGNIIAQIGWGIIGNLHLLFALAIGGSWANERAGGAFAAGLAFILINLITGHFFGVKIEMLTDPNTHVSTILAGDIPVANYFVNILGQPALNMGVFVGIIAGFVGATTFNSYYNFRKLPEVLTFFNGKRFVPFVVIYRSVLVALILAVFWPVVQTGINHFGEWIANSQDSAPILAPFVYGTLERLLLPFGLHHMLTIPMNYTSLGGTYEFLTGMQQGKQVFGQDPLWLAWISDLINLKDAGNMTQYNELLSTVTPARFKVGQMIGSSGILMGITLAMYVNVDTDKKTIYKGIFLSSALAVFLTGVTEPIEYMFMFVALPLYLVYAVIQGCAFAMADIVNLRVHSFGNIEFLTRTPMAIKAGIGMDLINFIWVSGVFAVAAFLIANFMIKKLNLATAGRNGNYDAKGSDEAPTEEKKVANASAQVVQIINLLGGRNNIAEVDACMTRLRITVHNPELVGDAAAWKQAGAMGFIVKGTGIQAIYGPKADVLKSDIQDLLSSGVEIPKM
>NZ_CP012067.1|WP_012771286.1|1319314_1320106_-|endonuclease/exonuclease/phosphatase-family-protein
MKLLTLNVHAWLEDNQAEKIDIIADTIVEKGYDIVALQEVNQLMSAPAISQALKQDNYGVVLLNKINQRATQKYSLFWSNSHIGYDKYDEGIAFLTRLPVYEVDAFYCSQHQRLDSILSRKILGLTVEYQGQLVDCYSCHINLPNCAGENQLDNIRNIVERSQSRNLKILMGDFNTDAISDPNAYQKIKSLGLLDTFEMAEQKDSGITVEKAIDGWKGHSEEKRLDYIFLNQAKRVLSSQVVFNGKNKPVVSDHFGLEVELTL
>NZ_CP012067.1|WP_080988249.1|1320115_1323889_-|4-alpha-glucanotransferase
MLTRSSGVLMHITSLPNAFGIGSFGQSAYDFVDFLVETKQSYWQILPLTTTSYGDSPYQSFSAIAGNTHLIDFALLTQMGLLQETDYASVNFGDDPTKVDYERIFYARRPILEIAVKHFLADKKRQSEFKNFEKNNRTWLEDYAEFMAIKEHFGNKALQEWEDKQAVARQPKALGKYRTMLKEQIQYFKVTQYFFFQQWLALKNYANQRGIKIIGDMPIYVAADSVEVWTMPELFQLDKERNPLFVAGVPADQFSTTGQLWGNPLYDWAEHKKQGYTWWIHRIEESFKIYDVLRIDHFKGFSDYWQVDGKADIAKYGSWQPGPGYDLFKAVKAQLGDLPIIAEDLGNIDEKAEKLLTDCGYPGMKILQFGFENVSGESLDSPHYCIPHCIAYTGTHDNDVINGWYADLSPKQQQYINAYTHRATDESVCQAMIRQLFATVSNTVIATMQDILDLPASSRMNIPSTIGGNWEWRMQESDLTKSKKDFLTQITTLYGRANKEKIMIKFSEFVQQKTNKKLEKLSDHAIYVQLLNYVKTLAANKGKNTAKRKVYYISAEFLIGKLLSNNLINLGVYQEIKDELAQAGKSLSHIEDIEPEPSLGNGGLGRLASCFIDSMSTLGLNAEGVGLNYHCGLFKQVFKNNEQHAEPNDWIEKESWLIPTDIRYEVPFKDFSLTSKLDRIDILGYKKDTKNYLNLFDIESINHKLIKKGITFDKTKIKENLTLFLYPDDSDKNGELLRIYQQYFMVSNAAQLLIDEAIERGSNLHDLADYAYVQINDTHPSMVIPELIRLLTEKYRIKFAEAVEIVRNMVGYTNHTILAEALEKWPLAYLEEVVPHLVKIIKKLNKLVHKEYPNPDVQIIDKQKRVHMAHMDIHFSNSVNGVAALHTEILKNSELKAFYEIYPEKFNNKTNGITFRRWLEFSNQELAAYIKQLIGDGYLHDATQLEKLLTFKDDKKVHQKLAEIKFRNKLALKTYLKENKGIELDENSIIDTQIKRFHEYKRQQMNALYVIHKYLEIKAGKLPKRKITVIFGGKAAPAYVIAQDIIHLILCLSELINNDPDVNQYLNVHLVENYNVSVAEKLIPATDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAELAGAKNIYTFGKDSESIIKLYETAGYVSKDYYKKDKHIKRAVDFILDSTLVKLGNEERLKRLHDELLNKDWFMTLIDFDAYVTAKEQILADYEDQDSWNEKIIHNIAKAGFFSSDRTIAQYNTDIWHCED
>NZ_CP012067.1|WP_050693408.1|1324086_1324800_+|UTRA-domain-containing-protein
MSKYKAVYNDIKRKITDGILPPKQELPSESELMQEYGFSKDTIRKALSLLEMDGYIQKQQGRTSIVLEHNLSTPQQLSEIKTVGELNRPLTHQVKTTLTSLYIVQGEEELMRIFNVNDQIDFYRIGRVREIDGEAVEYEVSYFDRRIVPFINREIAEQSIYHYLESELGLKISYSQREIVFRYANEEEKSTMALGEYNMVVNVTSTTYLADGRLFQYGSISYRPDKITFASTAKRHV
>NZ_CP012067.1|WP_050693409.1|1324939_1327213_-|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase
MTIFHLAGFPRVGAKRELKFAQERYWRGEIAEADLLDIAKKLREINWQHQANANADFVAVADFTFYDHILDLQVATGAIPARFGFDSQNLTLDQYFQLARGNKTQFAIEMTKWFDTNYHYLVPEFHKDTQFKANPAHYVQQIREAKALGHKVKPTIVGPLTFLWLGKEKGAAFNRFDLLNKLVPIYVDILNALTAEGVEYIQIDEPALTLDLPAEWVAAYKAVYATFAAQVNAKLLLATYFGSVAEHANLLKALPVAGLHIDLVRAPEQLSAFADYDKILSVGVIDGRNIWRANLNQVLDVVEPLKAKLGERLWIAPSCSLLHTPYDLAVETQLQANKPELYQWLAFTLQKIQELRVIKTALEQGRAAVQADLDASQTAADARKNSREIHRTCVAERLANLPKNADQRKSPFAERIKLQNAWLNLPLLPTTNIGSFPQTTEIRHARAAFKKGDLGLADYEAAMKKEIEFVVREQEKLDLDVLVHGEAERNDMVEYFGELLDGFAFTKFGWVQSYGSRCVKPPVIYGDVTRPEPMTVRWSQYAQSLTNKVMKGMLTGPVTILQWSFVRNDIPRSTVCKQIAVALSDEVLDLEKAGIKVIQIDEPAIREGLPLKRADWDAYLQWAGEAFRLSSMGCKDDTQIHTHMCYSEFNDILPAIAALDADVITIETSRSDMELLTAFGDFKYPNDIGPGVYDIHSPRVPTAEEIEHLLRKALQVVPKERLWVNPDCGLKTRGWPETIAALKVMVDVTKKLRAELA
>NZ_CP012067.1|WP_080988250.1|1327338_1327479_-|transcriptional-regulator
MRKIHINKKNNEAVSYTKTDCALMFYGIKVRSKINMFLRSVLLRQN
>NZ_CP012067.1|WP_050693410.1|1327477_1328410_+|LysR-family-transcriptional-regulator
MKPIFLELRHLKTLLALKETGSVSLAAKRVYLTQSALSHQIKLLEDQYGLPLFERKTQPLHFTQAGERLIQLANDILPKVIEAERDLARVKQGEAGELRIAVECHTCFDWLMPAMDLFRQHWPLVELDIVSGFHTDAVGLLLSHRADWAVVQEVEETPGIVYKPLFSYEMVGLCAKDHPLAVKDVWQAEDFIDQTLITYPVPDDMLDLLRKVLHPKGVNPTRRTSELTIAIIQLVASKRGVAALPFWAAKPYLDRGYIVARKITEQGLHSNLYAATRELDSQIAFVDDFYETVKAQSFSTLPELSILEEI
>NZ_CP012067.1|WP_050332750.1|1328414_1329146_+|branched-chain-amino-acid-transporter-AzlC
MSDVKTNSHPIWAAAKAALPYSAPMLAGFLFLGVAYGIYMKALGFSFWYPVLMALLIYGGSVEFIIAGALSLAFAPLNALLITLMVSGRQLFYSISMLEKYGKSLGKKRPYLIATLVDESFSLNYMAKVPSHIDRGWYMFFVSFYLHMYWMIGAGLGNLFGNIIPFDLKGIEFAMTALFLVIFAENWAQEKSHESSLLGLAIAAISLIVFGREYFLLPTLIGIWTVLTFRRPKLSSRLERIEE
>NZ_CP012067.1|WP_050693411.1|1329142_1329472_+|branched-chain-amino-acid-ABC-transporter
MTLTEQIITIGIAVLGVQFTRWLPFWIFPANRPIPEYIRYLGKVLPAAMFGMLVVYCYKNVDVFSGFHGVPEFISGVIVVALHLWKRNMFLSIAAGTMLYMFLVQQVFV
>NZ_CP012067.1|WP_050694186.1|1329630_1330479_+|DUF535-domain-containing-protein
MFPYEKRKLKLLREWLRYQARRLIFTKQCHAFVAFMNDNPQWQAVFRHHPYRVNTLLSQYCDKRFNSTQRLQAIQTNFAVAEAKFGKTLCETLIAQQPILLSQLTETLALQLRLNDIDPYEGFFAVGLTDSDQRTIYSASFTFLSDNRLLVASIQGPKGEEAQELVRVATKLLHGVRPMFMLVNAFKLLATQLNCRLEGIPHKNQAKYRWNDSAKLLFNYDEFWQENEGKLTENYWQIPTALERRPLEDIQSKKRSMYRKRYEMFDKMTADIQSLFTENTHE

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Crispr_ID: NZ_CP012067_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012067_2

1552448-1552589

Orphan

Consensus_repeat	Method
TGGAGCGGGAAACGAGGCTCGAACTCGCGACCCCAACCTTGGCAAGGT	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP012067_2

>merge|NZ_CP012067|2|1552448-1552589|CRISPRCasFinder
TGGAGCGGGAAACGAGGCTCGAACTCGCGACCCCAACCTTGGCAAGGTTGTGCTCTACCAACTGAGCTATTCCCGCATGAATTGATGTTGAGAATGGAGCGGGAAACGAGGCTCGAACTCGCGACCCCGACCTTGGCAAGGT

>NZ_CP012067|2|2|1552448-1552589|CRISPRCasFinder
TGGAGCGGGAAACGAGGCTCGAACTCGCGACCCCAACCTTGGCAAGGT	TGTGCTCTACCAACTGAGCTATTCCCGCATGAATTGATGTTGAGAA
TGGAGCGGGAAACGAGGCTCGAACTCGCGACCCCGACCTTGGCAAGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012067.1\|WP_050693555.1\|1555018_1556746_+\|phosphoenolpyruvate-protein-phosphotransferase-PtsI	unknown	unknown	gnl\|CDD\|183017
NZ_CP012067.1\|WP_050693556.1\|1557459_1559499_-\|oligopeptidase-A	unknown	unknown	gnl\|CDD\|182832
NZ_CP012067.1\|WP_050694195.1\|1545592_1546546_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NZ_CP012067.1\|WP_050693551.1\|1548398_1549889_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|236692
NZ_CP012067.1\|WP_050694194.1\|1543766_1545080_-\|GTPase-HflX	unknown	unknown	gnl\|CDD\|182934
NZ_CP012067.1\|WP_050693547.1\|1540197_1541604_+\|GTP-binding-protein-YcjX	unknown	unknown	gnl\|CDD\|225648
NZ_CP012067.1\|WP_005700304.1\|1554621_1554879_+\|phosphocarrier-protein-Hpr	unknown	unknown	gnl\|CDD\|182777
NZ_CP012067.1\|WP_050693548.1\|1541619_1542714_+\|TIGR01620-family-protein	unknown	unknown	gnl\|CDD\|235449
NZ_CP012067.1\|WP_050693550.1\|1546551_1548399_-\|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl\|CDD\|234630
NZ_CP012067.1\|WP_050693558.1\|1561701_1562355_-\|GTP-cyclohydrolase-II	unknown	unknown	gnl\|CDD\|234745
NZ_CP012067.1\|WP_005702996.1\|1556806_1557307_+\|PTS-glucose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|181859
NZ_CP012067.1\|WP_050694196.1\|1560034_1561603_+\|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173869
NZ_CP012067.1\|WP_050693553.1\|1550608_1552234_-\|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl\|CDD\|293741
NZ_CP012067.1\|WP_050693554.1\|1553353_1554394_+\|small-ribosomal-subunit-biogenesis-GTPase-RsgA	unknown	unknown	gnl\|CDD\|237039
NZ_CP012067.1\|WP_032996247.1\|1562428_1563172_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|182658
NZ_CP012067.1\|WP_005702982.1\|1545163_1545466_-\|RNA-chaperone-Hfq	unknown	unknown	gnl\|CDD\|179001
NZ_CP012067.1\|WP_050693557.1\|1559631_1559997_+\|YbaN-family-protein	unknown	unknown	gnl\|CDD\|377291
NZ_CP012067.1\|WP_005702992.1\|1552736_1553282_-\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429
NZ_CP012067.1\|WP_050693549.1\|1542810_1543770_+\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225821
NZ_CP012067.1\|WP_050693552.1\|1549902_1550379_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl\|CDD\|182615

Protein	Function_ID	Function_description	E-value
NZ_CP012067.1\|WP_050693555.1\|1555018_1556746_+\|phosphoenolpyruvate-protein-phosphotransferase-PtsI	gnl\|CDD\|183017	PRK11177, PRK11177, phosphoenolpyruvate-protein phosphotransferase PtsI.	0
NZ_CP012067.1\|WP_050693556.1\|1557459_1559499_-\|oligopeptidase-A	gnl\|CDD\|182832	PRK10911, PRK10911, oligopeptidase A; Provisional.	0
NZ_CP012067.1\|WP_050694195.1\|1545592_1546546_-\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	3.89657e-162
NZ_CP012067.1\|WP_050693551.1\|1548398_1549889_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|236692	PRK10431, PRK10431, N-acetylmuramoyl-l-alanine amidase II; Provisional.	5.34054e-106
NZ_CP012067.1\|WP_050694194.1\|1543766_1545080_-\|GTPase-HflX	gnl\|CDD\|182934	PRK11058, PRK11058, GTPase HflX; Provisional.	0
NZ_CP012067.1\|WP_050693547.1\|1540197_1541604_+\|GTP-binding-protein-YcjX	gnl\|CDD\|225648	COG3106, COG3106, Predicted ATPase [General function prediction only].	0
NZ_CP012067.1\|WP_005700304.1\|1554621_1554879_+\|phosphocarrier-protein-Hpr	gnl\|CDD\|182777	PRK10850, PRK10850, phosphocarrier protein Hpr.	6.74062e-37
NZ_CP012067.1\|WP_050693548.1\|1541619_1542714_+\|TIGR01620-family-protein	gnl\|CDD\|235449	PRK05415, PRK05415, hypothetical protein; Provisional.	2.28172e-159
NZ_CP012067.1\|WP_050693550.1\|1546551_1548399_-\|DNA-mismatch-repair-endonuclease-MutL	gnl\|CDD\|234630	PRK00095, mutL, DNA mismatch repair endonuclease MutL.	0
NZ_CP012067.1\|WP_050693558.1\|1561701_1562355_-\|GTP-cyclohydrolase-II	gnl\|CDD\|234745	PRK00393, ribA, GTP cyclohydrolase II RibA.	4.57163e-133
NZ_CP012067.1\|WP_005702996.1\|1556806_1557307_+\|PTS-glucose-transporter-subunit-IIA	gnl\|CDD\|181859	PRK09439, PRK09439, PTS system glucose-specific transporter subunit; Provisional.	1.474e-103
NZ_CP012067.1\|WP_050694196.1\|1560034_1561603_+\|peptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173869	cd08504, PBP2_OppA, The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding component of an ATP-binding cassette (ABC)-type oligopeptide transport system comprised of 5 subunits. The transport system OppABCDEF contains two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.27802e-139
NZ_CP012067.1\|WP_050693553.1\|1550608_1552234_-\|sulfatase-like-hydrolase/transferase	gnl\|CDD\|293741	cd16017, LptA, Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase. Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase catalyzes the modification of the lipid A headgroups by phosphoethanolamine (PEA) or 4-amino-arabinose residues. Lipopolysaccharides, also called endotoxins, protect bacterial pathogens from antimicrobial peptides and have roles in virulence. The PEA modified lipid A increases resistance to the cationic cyclic polypeptide antibiotic, polymyxin. Lipid A PEA transferases usually consist of a transmembrane domain anchoring the enzyme to the periplasmic face of the cytoplasmic membrane.	3.07427e-76
NZ_CP012067.1\|WP_050693554.1\|1553353_1554394_+\|small-ribosomal-subunit-biogenesis-GTPase-RsgA	gnl\|CDD\|237039	PRK12288, PRK12288, small ribosomal subunit biogenesis GTPase RsgA.	0
NZ_CP012067.1\|WP_032996247.1\|1562428_1563172_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|182658	PRK10699, PRK10699, phosphatidylglycerophosphatase B; Provisional.	8.68027e-55
NZ_CP012067.1\|WP_005702982.1\|1545163_1545466_-\|RNA-chaperone-Hfq	gnl\|CDD\|179001	PRK00395, hfq, RNA-binding protein Hfq; Provisional.	3.41317e-43
NZ_CP012067.1\|WP_050693557.1\|1559631_1559997_+\|YbaN-family-protein	gnl\|CDD\|377291	pfam04304, DUF454, Protein of unknown function (DUF454). Predicted membrane protein.	2.3251e-38
NZ_CP012067.1\|WP_005702992.1\|1552736_1553282_-\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	3.29982e-134
NZ_CP012067.1\|WP_050693549.1\|1542810_1543770_+\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|225821	COG3283, TyrR, Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism].	4.12452e-158
NZ_CP012067.1\|WP_050693552.1\|1549902_1550379_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl\|CDD\|182615	PRK10646, PRK10646, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE.	1.0419e-63

>NZ_CP012067.1|WP_050693553.1|1550608_1552234_-|sulfatase-like-hydrolase/transferase
MFKKFLSYLNSRIFWIWLLFFSFITLIISPENSAYYGIFVIYIIYYLIFSFNQKIFWLFITFVVITLSLYQPIYSSYGNLNSGVVAAFFETNPAESFEFLGKLKIDQFILPFLFSLSAYILYRLREQATPQGEITEKDIKYKKILNITLIIVTIFSIIWIPTKFHFENSSKEQIDSHWTLANSPVNLISFYANIIDSITDYYNDKKELETAKDVLPPWHIISTQPKYKNYVLIIGESARKDYMSTYGFKLPTTPFLDKTNGYINAGYVSAAPATYHSLLNTLHLKPKEKGKKDYSYNIISLAKAAGIKTFWLSNQGTIGKYDTLASRLGIGADFHYFTKKGGFITNNADDFKLLEELKIKFKEKSYENDTRLFVIHLMGSHRNFCQRITDKEKKLEFINESLSCYVNTILKTDKLIEEIVTVLKEQNEPYSLIYFSDHGLSHVNKENKKEVDLDFGEEHKQNFEVPFVKISSDDTSREVVNVKRSAFNFIYGFSQWLGIETKELDQEYNFFSNKNDENIKVFNFKENIPYNTLKNDDIPNL
>NZ_CP012067.1|WP_050693552.1|1549902_1550379_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MTERFTQYIPNENAMCAFGEKLIKAICQMSNNKSVMLYLNGDLGAGKTTLSRGMIQGLGHSGNVKSPTYTLVEEYKIGGKIIYHFDLYRLADPEELEFMGIRDYFAENTICLIEWAEKGAGLLAAADLLVNIAYAENARNIELLAESETGRQIIQQLN
>NZ_CP012067.1|WP_050693551.1|1548398_1549889_-|LysM-peptidoglycan-binding-domain-containing-protein
MKAQNIMRFILMHGLLFFAVLAFADNTWTIAIDPGHGGKDPGAIGRNLKIYEKNVTLSIAKELKALLDKDPHFRAVLTRNGDYYISVPQRSEIARKYKANYLVSIHADSSETPNLRGASVWVLSNRRANDEMGQWLEDHEKRSELLGGAGSVLASHNEKYLDQTVLDLQFGHSQRVGYELGNIVLRHFSQIASLSRPTPRHASLGVLRSPDIPSILVETGFLSNQEEELKLSTPAYRKRIAKAIYNGLAEYRRKNVKDEPKVAIVDKNEKTSEKSTALEVKDSGIRHTVKSGEGLGKLAEKYHVSTADIIALNKLKRKALWVGETIKIPDNGKNSPITEEKSVKAKENNSVEVKDSGIRHKVKAGENLGKLAEKYKVSANDILTLNKLKRKELLVGENLKIPATAKAETANKTEKGKETETPKPVDKSPKTQGKSKPEVKDAVPKFHTVKKNETLYSIAREYKIAPNKLLKLNPQLKNGKVLSGQKIKLTEEQGKK
>NZ_CP012067.1|WP_050693550.1|1546551_1548399_-|DNA-mismatch-repair-endonuclease-MutL
MTIRVLSPQLANQIAAGEVVERPASVVKELVENSLDAGADKIQIDIENGGAGLIRIRDNGIGIAKEELALALARHATSKIADLADLEAILSLGFRGEALASISSVSRLTLTSRTTEQHEAWQVYAQGRDMETTIQPASHPIGTTVEVANLFFNTPARRKFLRSEKTEFSHIDEVIRRIALAKFNISFTLTHNGKVLRQYKSAVTNEQKLKRVAAICGDDFIQNALQIDWKHDDLHLSGWVALPHFNRPQNDLNYCYVNGRMVRDKIITHAIRQAYAEYLSNDQYPAFVLFIDLNPNDVDVNVHPTKHEVRFHQSRLVHDFITQGISHALTSESLDFSATETERKIQEPMGLWEVSSKPNRSAAGPNMFTQPSTYSTGYRVEKQPSEGAYHSSQKHRQNPPHFNRDNITPSVLDAHKHLWMDSTAPSRSKITISEDSKPRSTCLHALALVGNHALLLQQEQHFYLLSLSRLQRLKLELNLTLTATSQPLLIPVIFRLSETQWQAWQQQKAWFTQVGFDFLAEDAQRKITLQKVSAHLRRQNLQQLIIALLNEPVENLSEFLTALLAQLDFPPIQVLADAVTMLTETEQLLNKQSHIRLSDLFLEINWQPYLTQLAD
>NZ_CP012067.1|WP_050694195.1|1545592_1546546_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MQHSEHKPPAIFLMGPTASGKTDLAIQLRQQLPVEVISVDSALIYRGMDIGTAKPTAEELALAPHRLIDICDPAESYSAMNFRHDALREMQNITAQGKIPLLVGGTMLYYKALLEGLSPLPSADEKVRSEIETKAIQIGWGGLHQELAKIDPISAQRINPNDSQRINRALEVFYLTGKTLTELTAQKGEALPYDILQFAIAPENREVLHLRIEQRFHKMIELGFQQEVEKLYQRSDLNENLPSIRSVGYRQMWEYLRGDYDHKEMIFRGICATRQLAKRQITWLRGWKSPIQCLDSLHPTQALEKVLVSVNSLSDKQ
>NZ_CP012067.1|WP_005702982.1|1545163_1545466_-|RNA-chaperone-Hfq
MAKGQSLQDPYLNALRRERIPVSIYLVNGIKLQGQIESFDQFVILLKNTVNQMVYKHAISTVVPARSVAHHNANQQQQHQQGQQQEAPSSVETNTDAQTE
>NZ_CP012067.1|WP_050694194.1|1543766_1545080_-|GTPase-HflX
MPENSTQTSDHTINNAIVVHCFFEQSKNTDDLTEFQLLAKSANVHILNVITATRSTPQAKYFIGSGKAEEIADAVRQYNADLILVNHSLTPAQARNLEALCDCRVVDRNGLILDIFAQRARSHEGKLQVELAQLKHLSTRLVRRKTGLDQQKGAVGLRGPGETQLETDRRLIKVRINQLQSRLEKVAKQRNQNRQTRQKADIPTISLVGYTNAGKSTLFNLITDANVYAADQLFATLDPTLRRLTLQDVGTTILADTVGFLRDLPHDLISAFKSTLQETTEASLLLHVIDCADNRKLENIEAVNQVLEEIGAQEVPRLLVYNKIDQLENVTPHIEYDEKHLPSAVYISANSGSGLDLLLEAIRLRLTEHILNLQITLPPSDGKLRHAFYQLNCVEKEEINEQGEFLLNIRLEKTEWLKLVKRFTQLTPFNPIQPDEN
>NZ_CP012067.1|WP_050693549.1|1542810_1543770_+|sigma-54-interacting-transcriptional-regulator
MTTLKNTNPFAQIVSKNPRMQDVIEKAKKFALLDVPLLIQGETGTGKDVIAKACHDFSERRDHAFLAVNCAGIPGEDAETEMFGRRNKDGEFIGFFEYADGGTVLLDGVEELPLTLQAKLLRFLSDGTFRRVGEEEERYANVRVICTAQQPLQHYVEQGKMRSDLFHRLNVLSLNLPLLRERKEDLVFLSHQLIQEISEKLGIFPPHFDENFLRYLQEYPWPGNIRELYNALYRACSLCQNNLLRIEDLGLAPETPHSRDIDQFITEGDTLDEMVGRFEAAVLNKFYAKYPSSRKLATRLGVSHTAIANKLRQYGIGKS
>NZ_CP012067.1|WP_050693548.1|1541619_1542714_+|TIGR01620-family-protein
MEKKVFTQNESDMNEDLNAQSAFIAKQEFHEEQAVPDTEDEKGIFEGELLEQQFEQSLQPKPRWWKKILGGVSLLFFVASVAQSVQWLVDAWQQNQWIYFAFSLVACAVILLGVSAIVGEWRRLAKLRHRAKIQTQSQQLLKSAVNFKDVFSSSEHQQAVSLCQEVSKLVHIDGQNPDFMQWQKQIHEAYSAREILHLFSQNVLQPVDKQAKKLITKASTESAALVAISPLALVDIFFIAWRNIRLINQIAQIYGIELGYFSRIRLLRMVLVNMAFAGATELIQDLGVNWLSQDLTAKLSARAAQGIGVGILTARLGIKAMEFCRPLAFQSNEKPRLSQLHKELLSHLSNTVFDQVKFKQKDKV
>NZ_CP012067.1|WP_050693547.1|1540197_1541604_+|GTP-binding-protein-YcjX
MLNHLQKELNELVNRGLDRTLRIAVTGLSRSGKTAFITSLMNQMLHINRVDNGHLPLFDAARQHRILAVQRVPQLDLSIPRFDYEGNLNALSQEPPIWPQSTRGVSETRLAIRYQRSNGLLRHLKEKGTLYLDIFDYPGEWLLDLPLLDLGFEQWSLELQRQLNGTHAELAQTWLNKVKKIKLTDSADEDILAQLAKDYTDYLWQCKKQGLHFIQPGRFVLPGELEGAPVLQFFPLLHLNASQWQQLKREAKSESYFAVLTKRYDYYRQHIVKGFYENYFESFDRQVILADCLTPLNHSRQAFNDMQQALQQLFRNFHYGKRHLLNRLFSPKIDKLMFIATKADHITTDQLPNLIGLMRQLVQEGGRYLEFADIVTDYTAIASIRATQQVVVNQNGKQFKALQGIRSSNKQKVTLYPGSVPGRLPSADFWQNQKFEFDQFEPRRLEQGENIPHLRMDAVLQFLLGDKL
>NZ_CP012067.1|WP_005702992.1|1552736_1553282_-|oligoribonuclease
MELDKQNLIWIDLEMTGLDPEKERIIEIATIVTDKNLNILAEGPVLAVHQPDELLNKMSEWCVKTHTANGLVERVKASKLNERAAELQTLDFLKKYVPKGTSPICGNSVAQDKRFLFKYMPELADYFHYRHLDVSTLKELAARWKPEILNGFTKQNTHLALDDIRESIKELAYYREHFLNI
>NZ_CP012067.1|WP_050693554.1|1553353_1554394_+|small-ribosomal-subunit-biogenesis-GTPase-RsgA
MSKPKLTQNQKRRIQSNNNKVLHRHQKKEIEWRDDMLGESQEGLVVTRYARHADVENAQGEIFRCNLRRTLSGVVVGDHVIWRQGNEQLQGVSGVIEGIHPRKNEISRPDYYDGIKVIAANIDRIIIISSVLPSLSLNIIDRYLVVCEEANIEPIIVLNKVDMLTEAQWLEADELLAIYRKIGYQTLMLSAQSGKNLEKLTALLSHGVSIFVGQSGVGKSSLINAVLPHVDAQVGEVSATSGLGQHTTTSSCLYHLPQGGSLIDSPGIREFGLWHLEEEQITKGYREFQTVLGTCKFRDCKHLSDPGCALRQAVEEGKISTVRYENYHRLLASRKEMKSQRHFSSE
>NZ_CP012067.1|WP_005700304.1|1554621_1554879_+|phosphocarrier-protein-Hpr
MYSKDVEITAPNGLHTRPAAQFVKEAKAFASDITVSSAGKSASAKSLFKLQTLALTQGTVITISAEGEDAEKAVEHLVALIPTLE
>NZ_CP012067.1|WP_050693555.1|1555018_1556746_+|phosphoenolpyruvate-protein-phosphotransferase-PtsI
MISGIPASPGIVFGKALVLKEEKIVLDTQKIKDSQIENEIARFYAGRDATVEQLNSIKDRAYQSLGEEKAAIFEGHLMILEDEELEEEIIDYLRSNHVNAAVAANVVIDQQVAMLSEIDDEYLKERAGDIRDIGNRLIKNILGMHIVDLGEINEEAILVAYDLTPSETAQLNLDKVLGFVTDIGGRTSHTSIMARSLELPAIVGTNNVTEKVKTGDFLILDALNNAVYVNPSQQEIQRLKTLQDKLAEEKAELAKLKDLPALTLDGHQVDVVANIGTIRDVEGAERNGAEGVGLYRTEFLFMDRDQLPSEEEQFIAYKEVVEAMNGNLVVLRTMDIGGDKELPYLNLPKEMNPFLGWRAIRIALDRREILNAQLRAVLRASAYGRLAVMFPMIISVEEIRELKSVIEELKVELRNEGKAFDEDIQVGVMVETPSAAINAKFLAKEVDFFSIGTNDLTQYTLAVDRGNELISHLYNPMSPSVLNLIKQVIDASHAEGKWTGMCGELAGDERATILLLGMGLDEFSMSAISVPRIKKLIRNVNYQDAKLLAEKALQQPTAAEIEQLISDFLAEKALN
>NZ_CP012067.1|WP_005702996.1|1556806_1557307_+|PTS-glucose-transporter-subunit-IIA
MGLFDKLFGSKDKKAVDVEIYAPLSGEIVNIEDVPDVVFSEKIVGDGVAIRPTGNKLVAPVDGVVGKIFETNHAFSMESKEGVELFVHFGIDTVELKGEGFTRIAQEGQSVKRGDTIIELDLPLLEAKAKSVLTPVVISNMDEISNIEKKSGEVVAGDSVVLVLKK
>NZ_CP012067.1|WP_050693556.1|1557459_1559499_-|oligopeptidase-A
MSNPLLTPTDLPAFSKIEPQYIEPAIKQLIEENRATVEHLLKQPHFTWENFILPLAEAGDRLSKVWSPISHLNSVKNSPELREAYQACLPLLAEYGTWVGQHQGLYEAYLQLKNSPEFANYSQAQKKAIENSLRDFKLSGISLPAEKQKRYGEIVARLSELTSQFSNNVLDATMGWEKIVEDESQLKGLPESALQAAKQSAESKGLSGYRFTLEFPSYIPVMTYCENRELREEMYRAFATRASDQGPNAGKWDNSALMQEILSLRVELAKLLDFNTYTELSLATKMAETPQQVLDFLTNLAQRSKAQGERELQELKDFCKTHYNLTALELWDLTFYSEKQKQHLYAINDEELRPYFPEERVLNGLFELIKRIFHIRAVERHGVETWHKDVRFFDLIDDTNEVRGSFYLDLYAREHKRGGAWMDDCIGRRKTLEGDRQKPVAYLTCNFNRPLGDQPALFTHDEVTTLFHEFGHGLHHMLTQIDVADVAGINGVPWDAVELPSQFMENWCWEEEALQFISGHYQTNEPLPKEKLTQLLKAKNFQAAMFVLRQLEFALFDFRLHHTFDANKSNQVLDTLHQVKAEVAVVPTVDWGRMPHSFSHIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNAQTGQSFLDEILTKGGSEEPMKLFKNFRGREPQLDALLRHKGIAN
>NZ_CP012067.1|WP_050693557.1|1559631_1559997_+|YbaN-family-protein
MKYFYTGLGFFFLAVGIIGIVVPYLPTTPFLLLTVFFFAKGSERVHRWFVGTKIYQKHLKDFHEQRALTMKTKISILMLSTSMLLAGFYFTPSWIGKSVIITVLLIKYWFFFFWIKTLEEE
>NZ_CP012067.1|WP_050694196.1|1560034_1561603_+|peptide-ABC-transporter-substrate-binding-protein
MRVAHFPLSAFRLFQFKSAVLFCGIFALSACDEKQQEPVTPHSTIETVQPQSIPPQGNRQLLVRGVYSDLVLNPSQAVNAEQFAFLRDLFEGLVIYDQRGNVIPAVAESWQTTDNKTWKFSLRQDAKWSNGEPVTAQQFVASWQALVTSNSPLRHYLAYINLANAESVLKGKLPADKLGISAENDRTLRLTLDKATPYLPQMLVHISLLPQYLAPHKGIVTNGAYQVAGQENHFIHLEKNPHYWAQDKVAFKHVDYQKIASQQDPIALDLVINPSKTEQAQYFPQLCTYFYAFNMKQPKLAQSSVRKALSMMAPSRNMNHDGKNFIYLSDNFLPISLQTVESHWEQIPMEQLLSQSKISEKAPLKLTLSYDQTELQSQIAQSLIRMWSQSDMIRIIGEGMPKQKLLENIAKGDFQIARSGWCADYNDPAAFLSLFYSHSPDNKSGYHNEEVDRLFEQSLQLMPSAERTAIYSRIEQILQQEKVVLPLYQTTVPIYINPTLNGYYLSNPTEVIYSKDLFRKIQ
>NZ_CP012067.1|WP_050693558.1|1561701_1562355_-|GTP-cyclohydrolase-II
MAKIELVAQANLPTEFGLFKIVGFEFPDSKKEHVALVLGDISNCDEPVLARIHSECLTGDALHSLKCDCGFQLAAALRQINQEGRGVLIYHREEGRGIGLINKIRAYSLQDQGMDTIEANLALGFAADERNFNVCADIFDLLGVKKIRLLTNNPEKIETMKQAGINVVERVPLNVGENRYNTAYLDTKAKKMGHFIVHNGEQHLMECPYCQEEVPKK
>NZ_CP012067.1|WP_032996247.1|1562428_1563172_+|phosphatase-PAP2-family-protein
MVINMLKRLSLYTLLLCLVPIFVWLSAWQWNGNIIFDSYEHPLYWLTESGSVPYAIITCGVFALLFLPLFSNRKQWILAVAVMAFSMVITQGVKSGLKNAFAEPRPFVTYVTEKTGSSAEAFYAQDRKARAQIVDQFYQTQRNVPEWIKGHYADEVGYSFPSGHTIFATSWLMLAVGFMQLIGNKRGSAKLLIGFMTLWAILMLVSRLRFGMHYPIDLFVSIFIAWLIHVGIFQFLVKKNYFQQEGR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP012067_1	1.1\|1316667\|37\|NZ_CP012067\|PILER-CR,CRISPRCasFinder,CRT	1316667-1316703	37	NZ_CP012067.1	1302568-1302604	0	1.0

1. spacer 1.1|1316667|37|NZ_CP012067|PILER-CR,CRISPRCasFinder,CRT matches to position: 1302568-1302604, mismatch: 0, identity: 1.0

ccgaccgcactttgcgctgatgttcgtgtaacacggc	CRISPR spacer
ccgaccgcactttgcgctgatgttcgtgtaacacggc	Protospacer
*************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP012067_1	1.9\|1317200\|33\|NZ_CP012067\|PILER-CR,CRISPRCasFinder,CRT	1317200-1317232	33	CP054927	Streptomyces fulvissimus strain NA06532 plasmid unnamed1, complete sequence	476971-477003	7	0.788
NZ_CP012067_1	1.9\|1317200\|33\|NZ_CP012067\|PILER-CR,CRISPRCasFinder,CRT	1317200-1317232	33	NZ_CP040820	Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence	192738-192770	10	0.697
NZ_CP012067_2	2.1\|1552496\|46\|NZ_CP012067\|CRISPRCasFinder	1552496-1552541	46	NC_014633	Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence	245215-245260	14	0.696

1. spacer 1.9|1317200|33|NZ_CP012067|PILER-CR,CRISPRCasFinder,CRT matches to CP054927 (Streptomyces fulvissimus strain NA06532 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.788

ctcgatgccgtgcgtccagttgtgc----gcgcctat	CRISPR spacer
ttcgatgccgtgcgtgccgttgtgccggggcgc----	Protospacer
.************** * *******    ****

2. spacer 1.9|1317200|33|NZ_CP012067|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040820 (Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence) position: , mismatch: 10, identity: 0.697

ctcgatgccgtgcgtccagttgtgcgcgcctat	CRISPR spacer
gccgatgccgttcgtccagctgtgcggcgtgaa	Protospacer
 .********* *******.******   . *

3. spacer 2.1|1552496|46|NZ_CP012067|CRISPRCasFinder matches to NC_014633 (Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence) position: , mismatch: 14, identity: 0.696

tgtgctctaccaactgagctattcccgcatgaattgatgttgagaa	CRISPR spacer
gacgctctaccaactgagctattcccgcatacattgtgccccttag	Protospacer
 ..***************************. ****   ..   *.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

725869 : 793492

Vibrio_phage(16.67%)

tail,plate,head,tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_050692973.1\|725869_728458_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	1.3e-190	43.1
WP_050692974.1\|728520_729024_+	hypothetical protein	NA	NA	NA	NA
WP_050692975.1\|729023_730058_+	DNA polymerase III subunit delta	NA	NA	NA	NA
WP_032995301.1\|730159_730429_+	hypothetical protein	NA	NA	NA	NA
WP_005704461.1\|730477_730882_-	8-oxo-dGTP diphosphatase MutT	NA	NA	NA	NA
WP_050692976.1\|730965_733665_-	preprotein translocase subunit SecA	NA	NA	NA	NA
WP_005701843.1\|733743_734061_-	DUF2547 family protein	NA	NA	NA	NA
WP_005704464.1\|734152_734464_+	DUF721 domain-containing protein	NA	NA	NA	NA
WP_005704465.1\|734502_734919_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_050692977.1\|734987_737819_-	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	0.0e+00	57.2
WP_050692978.1\|737988_738465_+	single-stranded DNA-binding protein	I3PUY5	Vibrio_phage	9.0e-42	59.1
WP_050692979.1\|738978_739350_+	hypothetical protein	NA	NA	NA	NA
WP_050692980.1\|739641_740490_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.5e-42	36.7
WP_050692981.1\|740685_741474_+	4,5-DOPA dioxygenase extradiol	NA	NA	NA	NA
WP_005701820.1\|741753_742122_-	rhodanese-like domain-containing protein	NA	NA	NA	NA
WP_050692982.1\|742445_743300_-	Dam family site-specific DNA-(adenine-N6)-methyltransferase	A0A1S6L1V5	Vibrio_phage	1.9e-58	46.8
WP_050692983.1\|743305_744394_-	3-dehydroquinate synthase	NA	NA	NA	NA
WP_050692984.1\|744415_744943_-	shikimate kinase AroK	NA	NA	NA	NA
WP_050692985.1\|745157_746582_-	type IV pilus secretin PilQ	NA	NA	NA	NA
WP_005701815.1\|746591_746987_-	hypothetical protein	NA	NA	NA	NA
WP_005701814.1\|746986_747520_-	competence protein	NA	NA	NA	NA
WP_005701813.1\|747516_748035_-	hypothetical protein	NA	NA	NA	NA
WP_050692986.1\|748048_748852_-	hypothetical protein	NA	NA	NA	NA
WP_050692987.1\|748978_751540_+	penicillin-binding protein 1A	NA	NA	NA	NA
WP_050692988.1\|751647_752493_+	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	NA	NA	NA	NA
WP_050692989.1\|752600_753971_+	glutathione-disulfide reductase	NA	NA	NA	NA
WP_080988234.1\|754162_754288_-	DNA methyltransferase	F6MIM2	Haemophilus_phage	6.9e-10	75.7
WP_080988235.1\|754298_754418_-	Com family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_050692990.1\|754549_754735_-	hypothetical protein	NA	NA	NA	NA
WP_050692991.1\|754740_755229_-	hypothetical protein	F6MIM0	Haemophilus_phage	4.1e-50	56.5
WP_050692992.1\|755221_755845_-	hypothetical protein	Q94MX9	Haemophilus_virus	1.1e-28	47.9
WP_050692994.1\|757323_757890_-\|tail	phage tail protein	Q6QI98	Burkholderia_phage	5.1e-44	48.2
WP_050692995.1\|757882_758989_-\|plate	baseplate J/gp47 family protein	NA	NA	NA	NA
WP_050692996.1\|758985_759351_-\|plate	phage baseplate protein	E5G6N7	Salmonella_phage	5.5e-07	36.8
WP_050694170.1\|759404_760019_-\|plate	phage baseplate assembly protein V	A0A291LA20	Bordetella_phage	2.8e-11	44.9
WP_080988236.1\|760018_761200_-	hypothetical protein	Q6QIA2	Burkholderia_phage	2.2e-68	42.5
WP_050692997.1\|761189_761426_-	hypothetical protein	Q6QIA3	Burkholderia_phage	6.9e-11	43.3
WP_050692998.1\|761403_762345_-\|tail	phage tail protein	Q6QIA4	Burkholderia_phage	1.8e-25	31.4
WP_050692999.1\|762344_764615_-\|tail	phage tail tape measure protein	K4ICR4	Acidithiobacillus_phage	2.5e-65	36.5
WP_050693000.1\|764651_764912_+	hypothetical protein	NA	NA	NA	NA
WP_050693001.1\|764924_765056_-\|tail	GpE family phage tail protein	NA	NA	NA	NA
WP_050693002.1\|765079_765328_-\|tail	phage tail assembly protein	NA	NA	NA	NA
WP_050693003.1\|765428_765947_-\|tail	phage major tail tube protein	A4JWK6	Burkholderia_virus	9.8e-34	40.8
WP_050693004.1\|765959_767342_-\|tail	phage tail protein	A4JWK5	Burkholderia_virus	1.7e-101	45.8
WP_050693005.1\|767351_767837_-	hypothetical protein	A4JWK3	Burkholderia_virus	8.1e-22	36.0
WP_050693006.1\|767838_768273_-	DUF1320 domain-containing protein	A4JWK2	Burkholderia_virus	2.2e-18	42.4
WP_050693007.1\|768272_768635_-	hypothetical protein	NA	NA	NA	NA
WP_050693008.1\|768707_769634_-	hypothetical protein	A4JWK0	Burkholderia_virus	3.5e-74	48.5
WP_050693009.1\|769646_770756_-	hypothetical protein	A4JWJ9	Burkholderia_virus	1.5e-76	43.1
WP_050693010.1\|771004_771505_-	phage virion morphogenesis protein	G8GWE3	Rhodobacter_phage	2.9e-14	30.9
WP_050693011.1\|771631_772888_-\|head	phage head morphogenesis protein	J9STS2	Pseudomonas_phage	1.3e-55	49.0
WP_050693012.1\|772887_774330_-	DUF935 family protein	Q6QIC0	Burkholderia_phage	5.1e-112	46.3
WP_050694171.1\|774329_775802_-	hypothetical protein	A0A2I7S9C5	Vibrio_phage	7.6e-164	62.9
WP_050693013.1\|775885_776455_-	DUF3486 family protein	A0A2I7S9D1	Vibrio_phage	9.4e-38	45.9
WP_050693014.1\|776477_776783_-	hypothetical protein	A0A0C4UR00	Shigella_phage	2.9e-25	58.6
WP_050693015.1\|776779_777109_-	DUF2730 family protein	NA	NA	NA	NA
WP_050693016.1\|777229_777481_-	DUF2681 domain-containing protein	NA	NA	NA	NA
WP_050693017.1\|777473_777707_-	DUF2644 domain-containing protein	F6MIK0	Haemophilus_phage	2.1e-20	72.9
WP_167552691.1\|777706_777859_-	hypothetical protein	NA	NA	NA	NA
WP_050693018.1\|777862_778414_-	N-acetylmuramoyl-L-alanine amidase	F6MIJ9	Haemophilus_phage	2.5e-75	69.3
WP_050693019.1\|778496_779060_-	hypothetical protein	NA	NA	NA	NA
WP_050694172.1\|779486_779930_-	hypothetical protein	L7THB5	Pseudomonas_virus	6.5e-10	30.9
WP_050693020.1\|779980_780346_-	helix-turn-helix transcriptional regulator	L7TKV7	Pseudomonas_virus	1.1e-23	52.5
WP_050693021.1\|780485_780863_-	transcriptional regulator	Q6QIE8	Burkholderia_phage	3.3e-23	47.0
WP_050693022.1\|780862_781402_-	hypothetical protein	A0A0M3LPP6	Mannheimia_phage	5.8e-37	39.5
WP_050693023.1\|781398_781866_-	regulatory protein GemA	A0A219VHC6	Ochrobactrum_phage	1.5e-09	31.7
WP_050693024.1\|781983_782163_-	hypothetical protein	NA	NA	NA	NA
WP_050693025.1\|782159_782363_-	ANR family transcriptional regulator	NA	NA	NA	NA
WP_050693026.1\|782515_783037_-	host-nuclease inhibitor protein Gam	F6MIJ0	Haemophilus_phage	5.4e-48	57.6
WP_155464852.1\|783029_783242_-	hypothetical protein	NA	NA	NA	NA
WP_050693028.1\|783283_783613_-	hypothetical protein	NA	NA	NA	NA
WP_050693029.1\|783612_784530_-	AAA family ATPase	M4M9P4	Vibrio_phage	2.4e-59	43.1
WP_050693030.1\|784553_786518_-	DDE endonuclease	M4M9R2	Vibrio_phage	1.8e-168	47.0
WP_048750443.1\|786526_786739_-	transcriptional regulator	A0A0C4UQU0	Shigella_phage	1.6e-11	47.1
WP_050693031.1\|786815_787511_+	putative DNA-binding transcriptional regulator	A0A2I7S9A5	Vibrio_phage	2.0e-26	39.4
WP_050693032.1\|787810_788455_-	cAMP-activated global transcriptional regulator CRP	NA	NA	NA	NA
WP_050693033.1\|788492_788711_-	YheU family protein	NA	NA	NA	NA
WP_050693034.1\|788734_789334_-	nucleoid occlusion factor SlmA	NA	NA	NA	NA
WP_050693035.1\|789333_789789_-	dUTP diphosphatase	Q2NP83	Xanthomonas_phage	6.2e-48	60.8
WP_050693036.1\|789941_791141_-	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	Q9HH70	Methanothermobacter_phage	2.8e-39	32.1
WP_050693037.1\|791318_791978_+	DNA repair protein RadC	NA	NA	NA	NA
WP_005542826.1\|792188_792425_+	50S ribosomal protein L28	NA	NA	NA	NA
WP_005544948.1\|792436_792607_+	50S ribosomal protein L33	NA	NA	NA	NA
WP_050693038.1\|792676_793492_+	DNA-formamidopyrimidine glycosylase	A0A127AWE5	Bacillus_phage	1.7e-19	29.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP012067

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection