CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP011340	Streptomyces pristinaespiralis strain HCCB 10218 chromosome, complete genome	21 crisprs	c2c9_V-U4,cas8e,WYL,csa3,DEDDh,DinG,cas3,cas4	1	10	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP011340_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_1

105084-105186

Orphan

Consensus_repeat	Method
GTCGCCGTCGACGGTCAGGCCGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_1

>merge|NZ_CP011340|1|105084-105186|CRISPRCasFinder
GTCGCCGTCGACGGTCAGGCCGGCGCCGGTCATGGTGTTGAGGTGGCGTTGCATGGCCTTCACCGTGGCCGGGCCGGTGTCGCCGTCGACGATCAGGCCGGCG

>NZ_CP011340|1|1|105084-105186|CRISPRCasFinder
GTCGCCGTCGACGGTCAGGCCGGCG	CCGGTCATGGTGTTGAGGTGGCGTTGCATGGCCTTCACCGTGGCCGGGCCGGT
GTCGCCGTCGACGATCAGGCCGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_037775665.1\|115904_116336_+\|4-oxalocrotonate-tautomerase	unknown	unknown	gnl\|CDD\|224853
NZ_CP011340.1\|WP_005322092.1\|110135_110897_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_CP011340.1\|WP_086025621.1\|95580_96696_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NZ_CP011340.1\|WP_158685257.1\|100443_100608_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_106428503.1\|100642_101860_-\|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|366736
NZ_CP011340.1\|WP_005322109.1\|98464_99481_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP011340.1\|WP_005322090.1\|111193_111901_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213984
NZ_CP011340.1\|WP_037777449.1\|109089_109956_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|223532
NZ_CP011340.1\|WP_005322104.1\|102209_102413_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP011340.1\|WP_037775668.1\|99716_100331_+\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|223340
NZ_CP011340.1\|WP_005322079.1\|115214_115805_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP011340.1\|WP_005322088.1\|112500_112806_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367559
NZ_CP011340.1\|WP_005322101.1\|102720_103107_+\|glyoxalase/bleomycin-resistance/dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|319925
NZ_CP011340.1\|WP_005322097.1\|107332_107752_-\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP011340.1\|WP_053556605.1\|103170_105027_-\|DUF839-domain-containing-protein	unknown	unknown	gnl\|CDD\|225752
NZ_CP011340.1\|WP_005322087.1\|113003_114278_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129987
NZ_CP011340.1\|WP_005322116.1\|94660_95584_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP011340.1\|WP_005322096.1\|107929_108946_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238042
NZ_CP011340.1\|WP_005322111.1\|96864_98181_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP011340.1\|WP_037775666.1\|111985_112432_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_037775665.1\|115904_116336_+\|4-oxalocrotonate-tautomerase	gnl\|CDD\|224853	COG1942, COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only].	3.81304e-06
NZ_CP011340.1\|WP_005322092.1\|110135_110897_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	1.19079e-38
NZ_CP011340.1\|WP_086025621.1\|95580_96696_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.86743e-80
NZ_CP011340.1\|WP_037775668.1\|99716_100331_+\|DNA-binding-protein	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	7.69353e-15
NZ_CP011340.1\|WP_106428503.1\|100642_101860_-\|aminoglycoside-phosphotransferase-family-protein	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	1.41298e-11
NZ_CP011340.1\|WP_005322109.1\|98464_99481_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.89695e-112
NZ_CP011340.1\|WP_005322090.1\|111193_111901_-\|hypothetical-protein	gnl\|CDD\|213984	cd12109, Hr_FBXL5, Hemerythrin-like domain of FBXL5-like proteins. Human FBXL5 (F-box and leucine-rich repeat protein 5) protein plays a role in cellular iron homeostasis. It is part of an E3 ubiquitin ligase complex that targets the iron regulatory protein IRP2 for proteasomal degradation. The FBXL5's stability is regulated by iron concentration, with its iron- and oxygen-binding hemerythrin domain acting as a ligand-dependent regulatory switch.	5.84411e-50
NZ_CP011340.1\|WP_037777449.1\|109089_109956_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|223532	COG0456, RimI, Acetyltransferases [General function prediction only].	1.59872e-06
NZ_CP011340.1\|WP_005322104.1\|102209_102413_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.65858e-36
NZ_CP011340.1\|WP_005322079.1\|115214_115805_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.66426e-09
NZ_CP011340.1\|WP_005322088.1\|112500_112806_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	5.85406e-21
NZ_CP011340.1\|WP_005322101.1\|102720_103107_+\|glyoxalase/bleomycin-resistance/dioxygenase-family-protein	gnl\|CDD\|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.88115e-18
NZ_CP011340.1\|WP_005322097.1\|107332_107752_-\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	4.78793e-10
NZ_CP011340.1\|WP_053556605.1\|103170_105027_-\|DUF839-domain-containing-protein	gnl\|CDD\|225752	COG3211, PhoX, Predicted phosphatase [General function prediction only].	3.91529e-140
NZ_CP011340.1\|WP_005322087.1\|113003_114278_-\|amino-acid-permease	gnl\|CDD\|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.21435e-48
NZ_CP011340.1\|WP_005322116.1\|94660_95584_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.56568e-77
NZ_CP011340.1\|WP_005322096.1\|107929_108946_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.57682e-09
NZ_CP011340.1\|WP_005322111.1\|96864_98181_-\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.12755e-28
NZ_CP011340.1\|WP_037775666.1\|111985_112432_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.00388e-09

>NZ_CP011340.1|WP_053556605.1|103170_105027_-|DUF839-domain-containing-protein
MRDDRHADADTARPDATGPSRRNIVAGGALAAAGLLVLGAPQAAAAPSAGRSATARRPLAPFTAVAASESDTVTVPTGCTATVLAPWGRPIRASGPRWRTDAGDTAAEQAQQVGSHHHGVQFFPLADGAAGNRHGLLVIGHEATDPDLLGGGADKAIAAQGLTVLEVRRSAGTWQAVDSARNRRVTGDTPVRFSGPVAVDGRPRGVLACSGHGITPWGTYLAAEENVNAAFGTDDPHWRRDEQHVRYGLSANGFGHPWHHFDARFDLAAPEARPEEFGWIVELDPHDPSALPVKRTALGRFAHGSATVTETAGRLVLHSTDAEDGGHLYKFVSSDNWRRLRDLGRSPLDHGTLYAARISPDGTGRWLPLTHGHGPLTRANGWHDQADVLVRARTAADALGATPLARPERVAVSPLDGRVYLALANSTGSSPCAGEAANGTTHTPCARSADPYGRVIRWRESEATPDRDGDGATPLSFHWEEFLTPDDPALRADGAFAAPKGLWFGADGTLWISTGVSGHTLNGPDDIHRTAGNNALLAADPTTKEVRRFLTAPRGAEVTGVTSTPDGQTLFVNIQHPGERTARWGAPGPDNPRAVSNWPDHSRNGRPRSATVAVHRTT
>NZ_CP011340.1|WP_005322101.1|102720_103107_+|glyoxalase/bleomycin-resistance/dioxygenase-family-protein
MVHVLGSRVLLRPTDPDRSRAFYGGALGLAVSREFGTGPERGTVYFLGGGFLEVSGRSENPPAPGLGLWLQVEDVQAAFEELRAAGVEVLRAPVMEPWGLIEMWIADPDGVRIAVVEVPENHPLRYRP
>NZ_CP011340.1|WP_005322104.1|102209_102413_+|cold-shock-protein
MATGTVKWFNPEKGFGFIEQDGGGPDVFVHYSAIASTGFRELFEGQKVQFDVTQGPKGPQAENVTPA
>NZ_CP011340.1|WP_106428503.1|100642_101860_-|aminoglycoside-phosphotransferase-family-protein
MDGGSRAAQRCLYRTTRTKSVRDTPVAPGPTAPDTRAPTGAQRRRPCPPGRARTSRRCAVNAPAKPSGTTYERAVHRLRRALGPVDVAGGRALTGGLYNCVHLFELADGRRLVLKSAPSAEAPALTHERQLLGTETIFHRLAATKGVSVPTVLHYEPAGPDDPGEWLLLDFLADSTWSEVGEDLPADGRPALRHRLGSALARTATATGPRFGYPQPVPGLQGDTWLEAFTGMMHAVLKDASRFGSPLPAATDTLAALPDRFADALDEVSRPALVHFDAWEGNVILTRDGDGGWRFGGLIDGERAFFGDPLAELVGLDPLGAAEDDPDLMAGYRSVTSDLPTTTPAARSRLALYRIYLALIMRVESIPRAYGPEHSAWLRSWSTERITQQLAVLDRLAAGQRLPSP
>NZ_CP011340.1|WP_158685257.1|100443_100608_-|hypothetical-protein
MGLTLRPAEAGPWLQLGNWPVLFDTASPLPSDMDGSWVEISVEADHVAVHPYRT
>NZ_CP011340.1|WP_037775668.1|99716_100331_+|DNA-binding-protein
MTRIIADISVSLDGFVTGPDPGPDNGLGTGGEALHTWAFSDDPDDRRVLREATVRSGAVVLGRRLFDVVDGPNGWDDTTGYGAGEVGKPAFVVVTSSPPESVRLTGLDWTFVTTGLPDAVAAARERAEAASSDSGKDLDVVLMGGGATVASALDAGLVDELTLHLAPVVLGAGTPLFTGVARRALVQRSVTSTSTATHLTYDVL
>NZ_CP011340.1|WP_005322109.1|98464_99481_+|LacI-family-transcriptional-regulator
MGGSRRPTIKTVAARAGVGRTTVSRVINGSPLVSDEARDAVLAAISELGYVPNSVARGLVTSRTDSIALVIPESESRLGSEPYFSAVIRGVSTGLADTRTQLQLVLVRDKGEQDQLTDSVAARRVDGVLLVSVHERDPLPGLLEDMGLPTVLAGRRSPAESLSHAHSDNVGGAAAAVRHLVERGRETITTITGPLDMDVGRSRLRGWREALDAAGRDSGEHLVAAADFTEEGGRQAMRSLLERVPGLDAVFAASDVMAVGAMTELRAQGRRIPQDVAVIGFDDSFIARHTDPPLTTVRQPVEEIGRTIARILLAEIVDPDAPRQHVVLPTELVVRDST
>NZ_CP011340.1|WP_005322111.1|96864_98181_-|extracellular-solute-binding-protein
MSRNQKLLRTRITGAVSAVAALGLIVGCSGGGGDSGTGGGVKDGKVTITMGLFGVMGYKETGLLDRYMKENPNVTIKAEVAGDEQTYYTALQTHLAAGSGLKDIQGIEIGRAKELVDTQADKFVDLAGVPGIDHYLPWKLSQVTTPDKKLIGLGTDIGPMAVCYRKDLFEQAGLPTDRNEVAKLWAGDWSKYVQAGKDFKAGFKGDGVAFMDSASGLFNAMIYGNSEQFYDKDGKLIYRDSPTVTGAWDLASQAATSGLTAKLRQFQPGWDPGLANSTFATTVCPAWMLGHITEKAGPKNKGKWDVAKAPKGANWGGSFLGVMEQSPVKEEAKKLVAWLTAPEQQEFVFQKLGNFPSSQKALTSPAVTGAKQEYFGNAPIGEIFGAAAQEIPDEQVLGRKDGTIKDIFSQGLTLIESQNKSPEEAWKTTDERIEKATG
>NZ_CP011340.1|WP_086025621.1|95580_96696_-|ABC-transporter-permease-subunit
MHGTGPRSLIRPDPNDRPRPSTSRPHRKAVPVAASTPVAPAGGPAGKHPAPGAPEDSAPPRRRALLHRLDVRGAPYAFVAPFFIVFAAFSFYPLVYTSWISLHRVELATMNVMEWVAFDNYVALWEDERFWNAVGNTITLGVISTVPQLLMALGLAHLLNYRMRGSTFFRVAALTPYATSVGAAALVFTMLFERDFGMINWMLGLFGFDNVDFENNKWAAQIAISTIVIWRWTGYNALLYLAAMQAVPRERYEAAAIDGASRWQQFLTVTVPGIRSTIVFTIVLSTIGATQLFGEPLIFGQGPNGITGGADNQYQTLGLLLYEEGWKNYQMGRAATVAWVMFLLLVLVFVIQRVVRRAASRRSAPTRSTAS
>NZ_CP011340.1|WP_005322116.1|94660_95584_-|carbohydrate-ABC-transporter-permease
MTTDSLPARAEPRPGDVQKSTGRTRRRPTLRIRAGRQHHAGPLAYVLLAIAALTSLFPLYWTMVAASTDNTRVTQTPPPLLPGPNLFENLARAWDEAAMGKAMINSLIVAGCIALATVLFATLAGFAFAKLRFKARNVLLMLVIGTMMVPPQLSVVPLFMMMSDLGWGQKLPAVIFPTLVSAVGVFFMRQYLAEALPDELVEAGRVDGAHSLRIFWSIVLPIARPAMSVLFMITFVHAWNDFFWPFIALDMSNPTVPVALTQLSAGYIRDQSLIMAGALLGTLPLLAMFVVFGRQIVGGIMQGAVKG
>NZ_CP011340.1|WP_005322097.1|107332_107752_-|peptidoglycan-binding-protein
MRRPTKLAAVTAVIGTALLAPAGPAAAAPPAAATAGIQAYSCDVTTTGDKLYAGYYSGESVTPSSTSVTAAGKEAQCLLRKRGFDPGTVDGIFGSNSQTAAKKFQLYVNGRCGRAVLDVDGKVGPRTWPYLRQVAFCFE
>NZ_CP011340.1|WP_005322096.1|107929_108946_+|helix-turn-helix-transcriptional-regulator
MLRIHFTDADLARTRVAAAPDPLWEICTSLHRFQSRQGRWAYADWHRTARAQLHATGFVRTLRTLLLPLVPRAAYFPDFLTPPESAGGLDAGLEAILATPKHRVMEEVGILAHTSGAPSWAPRLTEPGFREDLVKAMRTYHDTVIAPHHDVIQARIEAERSACARAVLDDGVEGILRNLGAPVLQWRRPVLHTVYPEDRDLRLDGRGLLLVPSYFCWGNPVTFGDTAHDPVLIYALNHEPHPATLKEEFSSGASLAALLGRTRAAVLRAAAVGATTGELARAVGVSAPSASQHARALRDAGLVTSRRNAASVLHTLTPLGAALLRANRRRGSNEGAQR
>NZ_CP011340.1|WP_037777449.1|109089_109956_+|GNAT-family-N-acetyltransferase
MAIVLGTPEVDGLGEAVGVLREWQYEGAPMQLHPGDLGWFWRSGAEATAAAVRTWRRDGRILAVGLLDGPGLLRLTIAPDARQDEELARQLAEDVSGPERGVLPAGKVNVEAPVGALVQDLLSEDGWGTDEPWTPLRRDLTEPVKDPGVRIEVVGPEQAHVFATALRAAFDGSRFTAERWHAMAAGLPYADARCLVAYDEAGGAAAVVTVWSAGPGRPGLLEPMGVHREHRRRGYGVAVTVAAAAALEELGSSSAIVCTPSSNAGAVATYRSAGFRPRPEVRDRYRDA
>NZ_CP011340.1|WP_005322092.1|110135_110897_-|MerR-family-transcriptional-regulator
MDWPIAEVARMSGVTARTLRHYDEIGLLPPARTGANGHRYYEENQLLLLQQILVLRALGLGLPEIGRILAEQVDEVEALRGHHRRLLAERDRLEALAGTVRRTIAELEKSRKDGTPMTAINRPENLFEGVRPAQYEESLHDFPEHAEAIARKVAAMTEQDVEAGQRERTAQMIRLAELMAGGHPADAEPVQAEADAQYRALSELRAVSAEEYRAIGRSCVDNDAWRAAYEAIAPGLAAYQRDAIEAYAATRLS
>NZ_CP011340.1|WP_005322090.1|111193_111901_-|hypothetical-protein
MPRIDLYRTVHMGQRERLFALAVETGAADTAEPECAGHLAKRCLAMTQELREHADHEDRFIHPLLRERAPEAADALDAEHVRLDAALTALDDRARRLPTTPAGSLPDAQHGLYLAVNELISAYLAHLHAEETVAMPALWDRCSDAELGEVFAAFKASRTPEESLADLRGMLPSLPPAVRTAIVRATLEAAPDDDAGRTLAAVSTTLDPRRRSRLYDDLGAPEAWALVESEREQAH
>NZ_CP011340.1|WP_037775666.1|111985_112432_+|winged-helix-turn-helix-transcriptional-regulator
MSDEMALLVADVFEAAGALRRLGEHTAQAEGLTQARWQVLSVVSETALTVPQAARRLGVSRQNVQRVANDLVTFGHAAYTANPDHRGSPLLALTPQGQEVLARVTTRASAVHRTLFAALPEEEIGRTRGLLRRLLEELDRREQADGRR
>NZ_CP011340.1|WP_005322088.1|112500_112806_+|helix-turn-helix-transcriptional-regulator
MREFQRGAVRLHILHHAAEEEIHGAWMTEELASHGYRISPGTLYPTLHRLEADGLLVSEQRVVDGRARRVYRATEAGRRALAEDRRALRELAREVLGDDAP
>NZ_CP011340.1|WP_005322087.1|113003_114278_-|amino-acid-permease
MSKPPAAAGVPDELRRRLGVPDAVMIGLGAMIGAGIFAALAPAAQAAGSGLLIGLALAAVVAYCNATSSARLAARYPASGGTYVYGRERLGDFWGYLAGWGFIVGKTASCAAMALTVGSYVWPGQAHAVAVAAVVALTVVNYAGVQKSAVLTRVIVAVVLAVLAAVVVAALTSGAFDPARLGIGDDATVGGVLQAAGLLFFAFAGYARIATLGEEVRDPARTIPLAVPVALGITLVVYAAVAVAVLTVLGPEGLARAAAPLSDAARAAGADRLVPVVRAGAALAALGSLLALILGVSRTTLAMARDRHLPHALAAVHPRFKVPHRAELAVGAVVAVLAATADVRGAIGFSSFGVLAYYAVANASAWTLSAEEGRPARIVPVVGLAGCLVLAFALPLSSVISGAVVLALGAAAYAVRRKVAARTS
>NZ_CP011340.1|WP_005322079.1|115214_115805_-|TetR/AcrR-family-transcriptional-regulator
MVRSSSGTQSRERIVAGAADMISRRGLSATSIREMAKHAEAPLGSTYHYFPEGKQQLAAEAVRHTGEWVARALRKELEAGPAAGLRAFLALWRKIVVDTDFHAGCPVLAVAIEEPPADEVPPALAAAAEVFDRWEGLLADSLREHGADAEQAAQVATLIVAAVEGTVALCRAKRSTEPLDRTAAQLQALIATTISG
>NZ_CP011340.1|WP_037775665.1|115904_116336_+|4-oxalocrotonate-tautomerase
MPMIRLTVPTGALTGQGRATVQRDLAAVLLRWEGAPDTAFFRAQAWSYLTELPGGAQVTAEDDAPRFLVEVTVPQGALSERRKAGLAREATATVLAAAGLSPAEAPRVWVLVNEQPDGTWGAGGSVVRYADLVALAKGRQADA

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Crispr_ID: NZ_CP011340_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_2

288862-288956

Orphan

Consensus_repeat	Method
GCGTCGTGCCGGTACCGCGTCGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_2

>merge|NZ_CP011340|2|288862-288956|CRISPRCasFinder
GCGTCGTGCCGGTACCGCGTCGTGCTGGTACCGCGTCGTGCTCGTGGTGCGGGACCGCGTTCCGCTCGTGGTGCGTGGTGCCGGTACCGCGTCGT

>NZ_CP011340|2|2|288862-288956|CRISPRCasFinder
GCGTCGTGCCGGTACCGCGTCGT	GCTGGTACCGCGTCGTGCTCGTGGTGCGGGACCGCGTTCCGCTCGTGGT
GCGTGGTGCCGGTACCGCGTCGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_037775603.1\|277709_278849_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NZ_CP011340.1\|WP_005321771.1\|278848_279223_-\|ectoine-synthase	unknown	unknown	gnl\|CDD\|380383
NZ_CP011340.1\|WP_050791653.1\|295684_296887_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375375
NZ_CP011340.1\|WP_053557667.1\|286013_288821_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223627
NZ_CP011340.1\|WP_086025680.1\|299472_300207_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NZ_CP011340.1\|WP_037775600.1\|281321_281585_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|376348
NZ_CP011340.1\|WP_078951197.1\|279287_280286_-\|tryptophan-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|237285
NZ_CP011340.1\|WP_037775595.1\|291520_292783_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|378005
NZ_CP011340.1\|WP_050791654.1\|288992_289850_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|130314
NZ_CP011340.1\|WP_078535443.1\|289846_291112_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|130256
NZ_CP011340.1\|WP_037775598.1\|283330_284062_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP011340.1\|WP_005321736.1\|291085_291379_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|367760
NZ_CP011340.1\|WP_053556627.1\|292779_293418_+\|dTDP-4-dehydrorhamnose-3,5-epimerase-family-protein	unknown	unknown	gnl\|CDD\|380337
NZ_CP011340.1\|WP_053556629.1\|296963_298691_-\|polyketide-synthase	unknown	unknown	gnl\|CDD\|238429
NZ_CP011340.1\|WP_053556625.1\|280278_281319_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234682
NZ_CP011340.1\|WP_063805376.1\|293420_294395_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223528
NZ_CP011340.1\|WP_005321757.1\|284325_284553_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_053556626.1\|281586_283113_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341253
NZ_CP011340.1\|WP_037775597.1\|284718_286017_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226729
NZ_CP011340.1\|WP_050791652.1\|298687_299476_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235936

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_037775603.1\|277709_278849_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	5.13265e-119
NZ_CP011340.1\|WP_005321771.1\|278848_279223_-\|ectoine-synthase	gnl\|CDD\|380383	cd06978, cupin_EctC, L-ectoine synthase, cupin domain. Ectoine synthase (EctC; also known as L-ectoine synthase or N-acetyldiaminobutyrate dehydratase; EC 4.2.1.108) is a cupin-like bacterial protein that converts N'-acetyldiaminobutyric acid to ectoine, in the last step of the L-ectoine biosynthetic pathway, via a cyclo-condensation reaction and using iron as the cofactor. Ectoines are potent microbial stress protectants, primarily synthesized by bacteria but also found in a few obligate halophilic protists and archaea, based on the ectoine biosynthetic ectABC gene. In halophilic eubacteria, the osmolytic ectoines enable the organisms to adapt to a wide range of salt concentrations by adjusting the cytoplasmic solute pool to the osmolarity of the surrounding environment. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	8.92531e-57
NZ_CP011340.1\|WP_050791653.1\|295684_296887_+\|hypothetical-protein	gnl\|CDD\|375375	pfam17843, MycE_N, MycE methyltransferase N-terminal. This is the N-terminal domain found in MycE from the mycinamicin biosynthetic pathway. MycE is a tetramer of a two-domain polypeptide, comprising a C-terminal catalytic MT domain and an N-terminal auxiliary domain, which is important for quaternary assembly and for substrate binding.	7.32956e-33
NZ_CP011340.1\|WP_053557667.1\|286013_288821_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223627	COG0553, HepA, Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair].	1.85338e-118
NZ_CP011340.1\|WP_086025680.1\|299472_300207_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	1.62851e-39
NZ_CP011340.1\|WP_037775600.1\|281321_281585_-\|acyl-carrier-protein	gnl\|CDD\|376348	pfam00550, PP-binding, Phosphopantetheine attachment site. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of the anguibactin system regulator AngR has the attachment serine replaced by an alanine.	0.00235785
NZ_CP011340.1\|WP_078951197.1\|279287_280286_-\|tryptophan-synthase-subunit-alpha	gnl\|CDD\|237285	PRK13111, trpA, tryptophan synthase subunit alpha; Provisional.	1.67775e-38
NZ_CP011340.1\|WP_037775595.1\|291520_292783_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|378005	pfam08484, Methyltransf_14, C-methyltransferase C-terminal domain. This domain is found in bacterial C-methyltransferase proteins. This domain is found C-terminal to methyltransferase domains such as pfam08241 or pfam08242. But this domain is not a methyltransferase.	1.33778e-65
NZ_CP011340.1\|WP_050791654.1\|288992_289850_-\|ABC-transporter-permease	gnl\|CDD\|130314	TIGR01247, drrB, daunorubicin resistance ABC transporter membrane protein. This model describes daunorubicin resistance ABC transporter, membrane associated protein in bacteria and archaea. The protein associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	2.31023e-14
NZ_CP011340.1\|WP_053556625.1\|280278_281319_-\|hypothetical-protein	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	2.58498e-48
NZ_CP011340.1\|WP_037775598.1\|283330_284062_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.38483e-20
NZ_CP011340.1\|WP_053556627.1\|292779_293418_+\|dTDP-4-dehydrorhamnose-3,5-epimerase-family-protein	gnl\|CDD\|380337	cd00438, cupin_RmlC, RmlC carbohydrate epimerase, involved in dTDP-L-rhamnose production. RmlC (deoxythymidine diphosphate (dTDP)-4-keto-6-deoxy-D-hexulose 3, 5-epimerase or dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; also known as RfbC) is a carbohydrate epimerase involved in the production of dTDP-L-rhamnose, a precursor of the bacterial cell wall constituent, L-rhamnose. L-Rhamnose (6-deoxy-l-mannose) plays an important role in the cell-wall structure of many bacterial species. It has been found to contribute to the virulence of several species, including the Gram-negative Salmonella enterica and Vibrio cholerae, where it is present as a part of the O-antigen, and is essential for the growth of Gram-positive bacteria such as Streptococcus pyogenes. RmlC converts dTDP-6-deoxy-D-xylo-4-hexulose to dTDP-6-deoxy-L-xylo-hexulose by catalyzing the epimerization of the 5-methyl and 3-hydroxyl groups of hexulose, the third of four steps in the dTDP-L-rhamnose biosynthetic pathway. RmlC belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	9.59925e-81
NZ_CP011340.1\|WP_053556629.1\|296963_298691_-\|polyketide-synthase	gnl\|CDD\|238429	cd00833, PKS, polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.	1.48303e-160
NZ_CP011340.1\|WP_078535443.1\|289846_291112_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	8.55184e-119
NZ_CP011340.1\|WP_063805376.1\|293420_294395_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	5.24656e-39
NZ_CP011340.1\|WP_005321736.1\|291085_291379_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	6.70225e-12
NZ_CP011340.1\|WP_053556626.1\|281586_283113_-\|AMP-binding-protein	gnl\|CDD\|341253	cd05930, A_NRPS, The adenylation domain of nonribosomal peptide synthetases (NRPS). The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.	1.3762e-92
NZ_CP011340.1\|WP_037775597.1\|284718_286017_-\|hypothetical-protein	gnl\|CDD\|226729	COG4279, COG4279, Uncharacterized conserved protein [Function unknown].	1.02808e-23
NZ_CP011340.1\|WP_050791652.1\|298687_299476_-\|hypothetical-protein	gnl\|CDD\|235936	PRK07110, PRK07110, polyketide biosynthesis enoyl-CoA hydratase; Validated.	1.05909e-67

>NZ_CP011340.1|WP_053557667.1|286013_288821_-|DEAD/DEAH-box-helicase
MWLAPEQAGLLARCAVVFEAGDPARTGRLVFYNPDGSPLPETAAGEPGKASLVVPHDGGVALRTFPVLRLAPAEALPALIEARRRHGRDGATVHPAAAFWGAAAALGLHLAARERLLPGVSVGGYDTWRAGPLDLEDVVRLRELAQAAPGEAVAAPGSDVQALLRAFLDAVADTLPRTAAAPAATGRAAFSATEPQHVPQLRAWAEEISAGLDSGVRVSLHVHLADTPDGPPALHLVPRAHSLADPTLALDAGELFASADHALGPRAQADTILAVRRAASVWEPLERLLPVPSALVLTDRETTELIGTGAARLRAHGIDVHWPEGAARSLTARAVVGAGRVPPADLRSFLGGDGTVDLRWQLALDGKPLTEEETAHVADEGRPLVRLRGRWTLVGADLARKARERDLGPLTAIEALAVALTGHTRIGTEQVPVAPSDWLLALRARLADPDGGTEPCRQPDALAATLRDYQLRGLRWLERMTSLGLGGCLADDMGLGKTIQLIALHLLRQEHDDTRGPTLVVCPASLLGNWQREIGRFAPGTPVRRFHGTGRSLEGADDGFVLTTYGTMRLDAERLGDHRWSMLVADEAQHVKNPLSGTAKALRLIPADAKIALTGTPVENSLSELWAVLDWTTPGLLGSHGHFRRRWMAPIDAERADATGEQPTARRLAGLVRPFLLRRRKSDPGIAPELPPKTETDRPVALTAEQSALYRKHAQEVMDRIRASQGIARSGLVLKLLTGLKQICNHPAHFLKQDDTALSGRSGKLELLDELLDTITAEGGAVLVFTQYVAMAKLLERHLRERGIGAQLLHGGTPVPRREELVQRFQDGEVPVFLLSLKAAGTGLNLTRADHVVHYDRWWNPAVEAQATDRAYRIGQTRSVQVHKMIAEGTIEDRIAALLESKKDLADAVLGSGEGALTELTNDELANLVELRSVC
>NZ_CP011340.1|WP_037775597.1|284718_286017_-|hypothetical-protein
MSDYEASGARGFAAFPARKGGRTRGQSPWAGRWTEALEDTWPEEEPLKKGRAFSRTGRIGPITVSAGRVAAEVYAGEAAHATTLTVKAWDDDDWDLLWERTADRPDATEALLAGDLPEDLLEAAEDARLGLLPGYGDLDADCDCDALDHPCPHATALGYQFSWLLDSDPWLLLLVRGRDTHEALDELKSVLMLRALTATDDEDDEEGEDDGGEDFAQEDRQEQEAYDSNREAYARPAAALPALPPLPEPLPSAAEPVTGIEADPLERLVADAAVRARELLAHIAGFGETPPAPPLDEWQDTVRIVATHPDPRVPARLREACGRPDDLDRAAAAWRTGGKAGLEVLEQPWTPSEQETARARTALAAGWDDDLPAFDVDGNHWTLTGRGLQLRRGRDARWYPYRDRSGTWWPAGPPDTDPAVALSELLDTPPES
>NZ_CP011340.1|WP_005321757.1|284325_284553_-|hypothetical-protein
MPFATDEIHVDHLCGIGPDGHRRGWFDVRVDPDALRRLGLHPDQPTARVIGPSPPRWWHAAAERDAHRHPHPPTG
>NZ_CP011340.1|WP_037775598.1|283330_284062_+|alpha/beta-hydrolase
MTTEDSLPIVFVHGTRFSAGQWSAQLAALRDEFEVAAVDLPGHGERAADPWSLSGATRIIASAVDALDRGPALVVGHSLGGYASLEFARRCPHHVRGLVLAGASASTRGPWATPYRWAAKLVPRIPVDRLTRWNDRLLRRLYPPEVVAATIRAGYAFHTLPAAWDEVLGRFDAGAMRHVKAPVLILNGEKDTVFRAGERDFARAHPRARVELIPRARHLANFDAPDAFTDAVRRFARQLLADG
>NZ_CP011340.1|WP_053556626.1|281586_283113_-|AMP-binding-protein
MGGGTLVEGIRAHARRAPQRTALVWHGDEVTYGALWRRAERERARVADTPGRGPVGVPAVKSPGTVALLLACMLERRPVLLPSATLGKDVLEQLYEQAGAVPLPDRPDDGPDDGPDDAGQGDAGQGDDTPYGDLRAAHDTPADPEAPVLLLTTSGSTGLPKIVPIAGGAVDRFTAWAADAFGIEEGTNVLNYAPLNFDLCLLDVWTTLAHGGRVVLVDPDQAMSGRHLLETIEHHDVHVVQAVPMFHRLVSDAARDHGTVLPSVRHAMTTGDALPGPVLAELPRLYPNARLHNIYGCTETNDSFVHEVTGEQAAAGATLPLGRPLPGAGALVVTDDGTVLEGPGSGELWVTTPFQTSGYLGAAAARPVFVPHPAGADGRRWYRTGDLVHRAADGALTLAGRTDFQVKVRGVRINVQEVEHVLLAHPEVTEAAVLALPDEVAGRLLHAVARRTPGSGLNSLALRGHLARGLPKAAIPSVLRFTDEPLPRTSTGKVDRDRVVKDHFTKEN
>NZ_CP011340.1|WP_037775600.1|281321_281585_-|acyl-carrier-protein
MPHAQAIKEFIVEEFLPDMPARDLADHDDLLEGGVIDSLGLLKVIAWLEDRYDINTDEVDLDPESFKSVAAIEAFIADASRTRAEAA
>NZ_CP011340.1|WP_053556625.1|280278_281319_-|hypothetical-protein
MHDAVAALIAQDRPVDLPQWRSFWDSLHDGALRRGESVALLASLSTQMPGRTTLTALLDSLAERRPGQGAGRPVFEGAVNIVGTGGGPRTLNISTAAALTAAAMGTRVVKTGSRAYTSALGSLDLLERLGIETASSYEQTHEMLERCGIAFAGMFVYPAELGLLARGVLPLDVRRLGRFVNALGPFLADMPVDAQLTGVSDPRLVPGLRHAAEHTARRTGGSVWLATNDTGADELVGFAPNLVRTYEGGGEDEFVLDPAALGLGPGGLEDLRPGADPVRDVLDLLAGRGRPAAEDAVCLNAAALAVAGRLTGDWHQALRGARAVLNDGSALALVDRLRRATEVAHA
>NZ_CP011340.1|WP_078951197.1|279287_280286_-|tryptophan-synthase-subunit-alpha
MPDPRPTPATGPTPATGPAPGTGPASAPGAAPVTGPASGTGPTHATATATATATGTGTAPRTAPAVVPAAEGFFTRAAPGRPGLALFLNAGDPPLDRLPDLVALLDESDIDCLELAVPFPGSVTDGPVIRRSADRALAHGTDLAAVLAAVARVRPGLKRLRIALLADFSHTVKGTAPGDFAAAVRDAGCDGLLLHGVPPRLRTAHYEAAHDAGLPLVTTCYAVSRPDAVAEAAAQATAYLYLVAHYGRSGTAAALDHDRLARSVAALRATATAPVAVGFGVRTRADTLLLQDLGADAAVVGSVGVARIEQALTEGRDPVEEFGSFVRELRGP
>NZ_CP011340.1|WP_005321771.1|278848_279223_-|ectoine-synthase
MIVRKLEEVTCVDWGNGLSRRFLTQADGVGYTVTDTIVRAGTKSRLEYRNHLESCYCIEGSGEVIDSDGVSHPITPGTLYALDRHDAHWLVASPHEDLRLVCMFTPALRGDESHNLDSPEFSHY
>NZ_CP011340.1|WP_037775603.1|277709_278849_-|acyl-CoA-dehydrogenase
MADFTKDQQALRDGLAPVLEKLDEGHVERDAAAEFPREAWRRLAGTGILGLPFDERYGGLGQSLTTTMYVLEGLGEGCRDAGLNFSACTHMVAAGVPLQRFGSDALKERHLPGICTGELIGAHAISEPDSGSDALAMRTRAVRDGDAYVLNGSKAFVSNGPVADVFTVYARTSDRPGPLSITAFLVDRDTPGLTLGRPLAKMGLRTSPLCELYFDDCRVPADRVVGRPGGGFLVLDHVMRWEILCSFVINAGEMQRRVDACVRYAQTRSQFGQPIGSYQAVSHKIVDMATGVETSRRWLYETARRMTAGDNVTRDIAMAKLVTSEANVASALAAVQIFGGNGYMAEFGIESQLRNAVAGTIYSGTSETQRNRIAALLGL
>NZ_CP011340.1|WP_050791654.1|288992_289850_-|ABC-transporter-permease
MSITAPRPMDRAALAPVIARTPLARLRWAAADGWTVTLRGLTHWVREPGTLIGSLAFPVMMVLMFGYFFGGAMQVPGGGNYREFLVPGMFVMTMVFGMGETVTAVAADKNRGVTSRFRTMPMAPSAVVVGRAVTDMLSSLLALAVLFATGLAIGWDAHGTLGETTLAVGLLLLLRFALVWAGIYLGLLMKGPEGITMVQTLEFPIGFLTSAFVAPSTMPGWLGTIAEWNPLSSTVLAVRELFGNPGFGGDSWIAQHALLMAVVWPVILCAVFFPLSVRRFRNLTS
>NZ_CP011340.1|WP_078535443.1|289846_291112_-|ATP-binding-cassette-domain-containing-protein
MEPVDESDHSDFPSLPCGPGPPRSRPLLEQPSNRRAPPAAPRGRRPAADRLPTVPRPDLERRSGPAQGRFGTLGRIPATRKEADVDPTSTAVLAEGLRKRYGDRYALDGFDLRVPAGTVHGLLGPNGAGKTTSVGILSTLLKADGGRAEVAGHDVSRQAAEVRASIGLVGQYAAVDEVLSGRQNLVMFGRLHHLSPAAARRRADELLEHFRLADTGKKPLKEYSGGMRRRLDLAASMVLAPPVLFLDEPTTGLDPRSRGEVWEAVRSLVDTGTTVLLTTQYLEEADQLAHAVSVIDSGKVIAEGTPDELKSRIGGDRIDVVVRRADQLPAAAAALEHVCAAPPDTDRDTRRISARVKDRTSALADIVRALDAAGVAAEDIALRRPTLDEVFLHLTGSGTGASTDGNGSDVSGDGAREAVAA
>NZ_CP011340.1|WP_005321736.1|291085_291379_+|antibiotic-biosynthesis-monooxygenase
MITFINRFHVTGATAEFEAAFDATSAFFADRPGFLNHRLLQHLDEPHLYVNIADWKDEESFRAALAHPEFAAHRARLRTLSSSDPNLYVPLLERVAR
>NZ_CP011340.1|WP_037775595.1|291520_292783_+|methyltransferase-domain-containing-protein
MEMKIDECRICGNRALLPVLDLGSQALTGVFPKNREETVASVPLELVKCSQPDGCGLVQLLHTADFDLMYGDHYGYRSGLGEFMIRHLQDKVASLLKTVEVRPGDIVVDIGSNDSTLLRGYPSDPALRPQLVGIDPTGGKFRHLYPEGAELITEYFSRKVFAERFGSRRAKVVTSVAMFYDLPRPMEFMQDVHDILAEDGVWLMEQSYMPAMLEATAYDVVCHEHLEYYALSQIEWMAERVGLKVVRAELNDVYGGSLCAVLARKDSSVAVDEASVARVRAHETALALDTAAPYEAFAARTVRYREELLAFLDDSRRSGKLTLGYGASTKGNVILQYCGLSEKDLPVIGEVNPEKHGAFTPGTYIPIVSQEEARSRRPDQLLVLPWIYRDGFVERERAYVAGGGRLVFPLPVLDVVGGAR
>NZ_CP011340.1|WP_053556627.1|292779_293418_+|dTDP-4-dehydrorhamnose-3,5-epimerase-family-protein
MTAGTARGFSTSTATVRELAVAGAYEFTPRVHRDERGLFVSPLQEEAFVAAVGRPFTVAQTNHSRSARGVMRGVHFTTTPPGQAKYVHCARGRAMDVVVDIRVGSPTFGAWDTVEMDTESFRAVYLPEGVGHAFLSLEDDTVMSYLVSTPYRADLEQAIDPLDPALGLPWPKDMSFTLSRRDTQAVGLAEARAKGMLPRYEDCPAAAAAADR
>NZ_CP011340.1|WP_063805376.1|293420_294395_+|NAD(P)-dependent-oxidoreductase
MRPGPGGARAGRVAVVGATGCVGRHVCAAFAGGGSEVVGVARRYAPHVGAHRFVPLDAAGCSPEQLAEFLAAEAVDAVVNATLGWGEELHRVNVELVERLIGALRLLPAARRPRLVQLGTVHEYGPVPQGTPVTELTPPAPVTEYARAKLAASRAVLGAAGIDAVVLRMANTIGPHPAPGSFLGSLAARFTEAAASPGERIELTVAAGARRDYVDVRDAADAVVRAAFAGHLGQDQRLFNIGTGTARGIDTLVLALAQACGLPASALALRTGEVAAQGASTGTDFTCLDASRARAVLGWSPRRSPAESMRAMAETARATCFATS
>NZ_CP011340.1|WP_050791653.1|295684_296887_+|hypothetical-protein
MTIQRAHDDILKLILAAEGGTEQIDAAIRAVGAERTAAILADELVNRADLHEIPGPGTAGVDIQLALAFDGGTVHHVVRVGKSAEHEAGRVDAPHATLESDLAELLRSVLGPWRGVEAQTLRIVWHDLENVERLGGTMHVFPVVRRLVRGTTGRHEDLGELSLRNGSDKWGLHFYTPHYDRHFGPLRDRPLKILELGIGGYGNPASGGGSLRMWKRYFPRSVVYGVDVFDKAPLREQRIHTVEGDLSNPEFLESLGRDLGPFDIVIDDASHGNADLIAAFKALFPYVRPGGLYAAEDLQTSYWPGYGGSSKELNSPATSMGFLKALLDGLNHEERELPEGTTASETDLTLTGAHFYPSLAIFEKGVNAEGASASWIPRQQMSYEEMSAVDWGEGLTADKD
>NZ_CP011340.1|WP_053556629.1|296963_298691_-|polyketide-synthase
MTTAHGTDAAPVAVIGMSCRTAGAETLTEFWDVVSRGERHLHDVPAGRWYGLDEQVAAANTPRAFLLDSIDGFDARFFGIAHRMAAFMDPQHRLMLELAWHAVENAGLDPQTLTGEPVAVFAGAFMSDYAERMTARGRRSDGAAFPGTMMAFLANRVSYQFGWTGPSMVIDSACSAGLSALGFAVQGLRAGDYPMALVGSPNLFSAGYYTTNAYLGGALSPTGDSVPFSAARNGYLRGEGGACLLLKPLDAALADGDPVHAVIRSVGSAHNGRGGGLTGTDQDSQTALVRQTLAKAGLTPRDLGHLEAHGTGTRGGDATEIAALAHLVDGPAAGPDGRLWVGSVKANIGHLEAAAGLIGVVKTILALRAGTIPRIAGLDEADGKLPVGDAPLGLPVENVPWPAGSTPRIGAVNAFGLGGSMSHAVVEEAPRPPRPATAAPAAGPAGRPHVVPLSAGSEEAVALLARRLLHQLDGPHAPELASLAHTLQYGRRAMKHRRALVVSDTAALRTALRSVADGADLPPAQDPLARAWADGATPDWDVLWKEHDRPARAHLPGTPYQRRSYWFDDEPPPAL
>NZ_CP011340.1|WP_050791652.1|298687_299476_-|hypothetical-protein
MTALSYGPVQLHTEAPVATVRMCDEAGHNRFTPELRAGLIAALQRAGDDRDVRAVVLEGAPGVFSAGGATERMLGTHEQRVVELWEMMQAIAACPVPVVAAAQGHALGGGLLLALYCDIAVLSERSRYAMNFLTFGFTPILGASHVVPAAFGRALGTEMMYTSRTYTGRELRERGAGTRICAHDTVPAEAHRIALQSAQAPRGALAMMKSQLVRTLLTDARAALEREIPDHEATITGDEARRRIRGLHGQRITRAGQPEAAA
>NZ_CP011340.1|WP_086025680.1|299472_300207_-|enoyl-CoA-hydratase/isomerase-family-protein
MRVDTGRPPLVRATLDTPATRNRLDDDMLTALTGALTAAEAAEGAEVFVLDATGDSFCSGIALGEADRDGWRPRLTAVHHLLQRLADSPLVTVAVVDGAATGGGVGLAAACDHVIAGPRASFRMTEVLLGLVPAVILPVVAERTGRHRAFSLALGAQHVSAEQAADIGLADQRTDDCRQELRLLLRRLRAADHGAVRALKRYRRELFPAPEGHADRALRAVAERLADQRVHERLNTLHRQGLIP

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Crispr_ID: NZ_CP011340_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_3

1336092-1336180

Orphan

Consensus_repeat	Method
CCCGCGCAGCGGCAACGCCCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_3

>merge|NZ_CP011340|3|1336092-1336180|CRISPRCasFinder
CCCGCGCAGCGGCAACGCCCCGCCACCGACACGCCCGCGAGGCGACCGTCGCACCCCGGCCGCACACCCGGCAGCGGCAACGCCCCGCC

>NZ_CP011340|3|3|1336092-1336180|CRISPRCasFinder
CCCGCGCAGCGGCAACGCCCCGCC	ACCGACACGCCCGCGAGGCGACCGTCGCACCCCGGCCGCAC
ACCCGGCAGCGGCAACGCCCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_005309201.1\|1333653_1335006_+\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NZ_CP011340.1\|WP_005309198.1\|1329178_1330096_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176106
NZ_CP011340.1\|WP_053556735.1\|1336188_1337664_-\|xylulokinase	unknown	unknown	gnl\|CDD\|198375
NZ_CP011340.1\|WP_037775954.1\|1327302_1328073_-\|3-oxoadipate--succinyl-CoA-transferase	unknown	unknown	gnl\|CDD\|224968
NZ_CP011340.1\|WP_005309207.1\|1344559_1345465_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NZ_CP011340.1\|WP_053556738.1\|1343881_1344463_-\|cysteine-dioxygenase	unknown	unknown	gnl\|CDD\|380416
NZ_CP011340.1\|WP_053556733.1\|1323584_1324856_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP011340.1\|WP_005309202.1\|1335025_1335487_+\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|239534
NZ_CP011340.1\|WP_005309204.1\|1337832_1339002_+\|xylose-isomerase	unknown	unknown	gnl\|CDD\|237170
NZ_CP011340.1\|WP_005309208.1\|1345605_1346418_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|252734
NZ_CP011340.1\|WP_053556737.1\|1342835_1343882_-\|putative-sulfate-exporter-family-transporter	unknown	unknown	gnl\|CDD\|225411
NZ_CP011340.1\|WP_106428394.1\|1339056_1339551_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NZ_CP011340.1\|WP_005309195.1\|1325653_1327183_-\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|236211
NZ_CP011340.1\|WP_053556734.1\|1330102_1331731_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	unknown	unknown	gnl\|CDD\|273793
NZ_CP011340.1\|WP_158685135.1\|1325058_1325565_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_078951208.1\|1339560_1342533_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|197715
NZ_CP011340.1\|WP_005309211.1\|1349295_1349511_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_050791685.1\|1328126_1329044_-\|CoA-transferase-subunit-A	unknown	unknown	gnl\|CDD\|224702
NZ_CP011340.1\|WP_005309200.1\|1332130_1333354_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|235741
NZ_CP011340.1\|WP_005309209.1\|1346740_1347211_+\|cation:proton-antiporter-regulatory-subunit	unknown	unknown	gnl\|CDD\|223564

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_005309201.1\|1333653_1335006_+\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.22738e-146
NZ_CP011340.1\|WP_005309198.1\|1329178_1330096_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.36031e-64
NZ_CP011340.1\|WP_053556735.1\|1336188_1337664_-\|xylulokinase	gnl\|CDD\|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	1.79554e-136
NZ_CP011340.1\|WP_037775954.1\|1327302_1328073_-\|3-oxoadipate--succinyl-CoA-transferase	gnl\|CDD\|224968	COG2057, AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism].	3.33998e-44
NZ_CP011340.1\|WP_005309207.1\|1344559_1345465_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.59748e-61
NZ_CP011340.1\|WP_053556738.1\|1343881_1344463_-\|cysteine-dioxygenase	gnl\|CDD\|380416	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain. This family contains cysteine dioxygenase (CDO; EC 1.13.11.20), which catalyzes the conversion of cysteine to cysteine sulfinic acid, the first step in the biosynthesis of essential oxidized cysteine metabolites such as sulfate, hypotaurine, and taurine. CDO also plays an important role in the regulation of intracellular cysteine levels in mammals; CDO expression is altered in cancer cells, and abnormal or deficient CDO activity has been linked to Parkinson's disease, Alzheimer's disease, and rheumatoid arthritis. CDO is an iron-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate cysteine sulfinic acid. The CDO active site contains an amino acid-derived cofactor. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	9.56939e-31
NZ_CP011340.1\|WP_053556733.1\|1323584_1324856_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.80399e-52
NZ_CP011340.1\|WP_005309202.1\|1335025_1335487_+\|MaoC-family-dehydratase	gnl\|CDD\|239534	cd03450, NodN, NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their legume hosts, a symbiotic process that requires production of Nod factors, which are signal molecules involved in root hair deformation and meristematic cell division. The nodulation gene products, including NodN, are involved in producing the Nod factors, however the role played by NodN is unclear.	1.92912e-75
NZ_CP011340.1\|WP_005309204.1\|1337832_1339002_+\|xylose-isomerase	gnl\|CDD\|237170	PRK12677, PRK12677, xylose isomerase; Provisional.	0
NZ_CP011340.1\|WP_005309208.1\|1345605_1346418_-\|SAM-dependent-methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	5.20313e-131
NZ_CP011340.1\|WP_005309209.1\|1346740_1347211_+\|cation:proton-antiporter-regulatory-subunit	gnl\|CDD\|223564	COG0490, COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism].	5.34147e-39
NZ_CP011340.1\|WP_106428394.1\|1339056_1339551_-\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	6.64103e-11
NZ_CP011340.1\|WP_005309195.1\|1325653_1327183_-\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|236211	PRK08268, PRK08268, 3-hydroxy-acyl-CoA dehydrogenase; Validated.	7.12458e-179
NZ_CP011340.1\|WP_053556734.1\|1330102_1331731_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl\|CDD\|273793	TIGR01766, Putative_transposase_MJ0751, transposase, IS605 OrfB family, central region. This model represents a region of a sequence similarity between a family of putative transposases of Thermoanaerobacter tengcongensis, smaller related proteins from Bacillus anthracis, putative transposes described by pfam01385, and other proteins. [Mobile and extrachromosomal element functions, Transposon functions].	6.62446e-06
NZ_CP011340.1\|WP_053556737.1\|1342835_1343882_-\|putative-sulfate-exporter-family-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	7.38827e-63
NZ_CP011340.1\|WP_078951208.1\|1339560_1342533_+\|AAA-family-ATPase	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	6.54913e-16
NZ_CP011340.1\|WP_050791685.1\|1328126_1329044_-\|CoA-transferase-subunit-A	gnl\|CDD\|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	1.17249e-55
NZ_CP011340.1\|WP_005309200.1\|1332130_1333354_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|235741	PRK06205, PRK06205, acetyl-CoA C-acetyltransferase.	0

>NZ_CP011340.1|WP_005309202.1|1335025_1335487_+|MaoC-family-dehydratase
MAPFIADGIPEISALAGRDLGHSRWREVTQDLIDMFAAVSGDHQWIHTDTERAAQGPYGGTIAHGYMVLSWGIPMFAELLQVTGVGMALNYGVNKVRFPAPVPVGSRVRLHATVTSVAPVKRGGVGMTRAFTFELEGSAKPACVAESLTHVYP
>NZ_CP011340.1|WP_005309201.1|1333653_1335006_+|MHS-family-MFS-transporter
MSASTAREQKRTANRAGLGAFIGSTIEWFDFYIYGTAAALVFDEVFFPELEGPLGTLVAFATFWVGFLARPLGGIIFGHFGDRLGRKKTLVITLLMMGIATTLIGLLPGYSSIGVAAPILLVCIRMVQGIGLGGEWGGSVLIASEHAPKGKSILYGAFAQQGSPVGNTLSTISFLAISQLPNDAFVSWGWRIPFLASAVLVFVGLFVRMRVAESPAMAKAIRTKNVSKLPLTEVLRTQPTLILLGIGACTIGLSATYFKSTFALSWATSSLDFDRSSFLTIILVANVLQVLVQPFGAVLATRMKSMTRAVCVMLLPEIFLLPLMFVLIGTENYTLAMIGVSVATIPHCLYYAALAGMLASRFPANVRYTGISLCYQLCGTILGGTTPIVGQSLLNWTGSITAVIIYAVFQVLLTLGCMVLILRRPNHDELADDPAEQPAPGTTATVTTTV
>NZ_CP011340.1|WP_005309200.1|1332130_1333354_+|acetyl-CoA-C-acetyltransferase
MSGQPDVVICEPLRTPIGRFGGALSSLRPAALAAHVIAEVVRRTGIDPGQVDEVILGHAYPTSDAPAIGRVAALDAGLPVSVTGVQVDRRCGSGLQAVLDAAMQIRAGFSDVVIAGGVEVMSAAPYYTHDGRWGIKGPGLQLHDSLARGRVTAGGVNHPVPGGMIETAENLRREYGISREDQDALALRSQQRAGRAMETGLFGDEIVPVPVRGRKGETLVSADEHPRPDTTAEKLASLRPLTIGSDPEATVTAGNASGQNDAAAACLVTSAETAARLGLTPMVRLVSFARAGVPAGTMGIGPVPATRAALERAGLKLADLDLIELNEAFAAQVLACTRELGLSEADHERINVNGSGISLGHPVGATGGRILATLAHEMRRREARYGLETMCIGGGQGLAAVFERVTA
>NZ_CP011340.1|WP_053556734.1|1330102_1331731_-|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MGGLREVAAPFVASGPSGVAVRTRLKGLTAGDEEVLRLVGAHLGSLASRDLKARCVEGLEHDSESWAVRKRGLTGVSSSRWAGSITKATHDQWALARRGQAAHIQGLEAGIRTIAHRLSLPVGAKGTRRVPGGYRSAHEWFHKTRRLRVLEDRLGRVRADRDAGRVRVVCGGRRLARTGHHLAEAGLTAAQWRRRWEAGRWFFQADGESGKRFGNETIRITPEGDVSIKLPAPLAHLANAAHGRYALAGRVRFAHRGSEWADRVAANRAVAYRIHHDTGRDRWYLTASWQIPPTPTVPLEAALAHGVIGVDTNADHLAAWRLDTHGNPCGEPRRFAYDLTGSAPHRDAQVRHALTRLLHWAKACGVKAIAVEDLDFQAEKTREKHGRRRRFRQLISGMPTGRLRARLVSMADRTGMTIIAVDPAYTSKWGAQHWQKPLTSTTRKTSRHDAASIAIGRRAQGHPIRRRTTPPPHDQSDRAGHRTVQAGPGTLGREETRPRIPGPRTRCVPPDAERKRATRAPNTVRGARSDQEWVQNPLLLTE
>NZ_CP011340.1|WP_005309198.1|1329178_1330096_+|LysR-family-transcriptional-regulator
MELRYLTSFVAVAEELHFGRAARRLQMAQPPLSQQIRQLERELGVQLFERNTRSVRLTSAGQSFLKPVRTVLDDLDIAVRVAKAAGQGEYGRVTVGFAGASSHHTLPLLTRAVRAAHPGLELVMQGQTYADVALAKVADGSLDLGFVRLPAGRPGVETRVIGEEELLCALPQDHPLASQERIPVADLAGEPFVSFPANAGSTLRDATFRACEEAGFHPRVVQEAPDSYTILALVAAGVGVTLTLSSCLHIQQTGLVHRPLAGPPTRLQAALAWRTDNPSAALRSVLAVAAEALPTPAGPAGMPRD
>NZ_CP011340.1|WP_050791685.1|1328126_1329044_-|CoA-transferase-subunit-A
MTMKDAIASYVHDGDTVSLEGFTHLIPTAAGHEIIRQGRRNLTVVRMTADIVVDQLLAGGCVTKLVSSFVGNSSAGSLGELRRRIEAADPEPLEFEEYSHYGMICRYIAGAQRLPFHPLRSYAGSDLPSVNPGIRKVTSPYPGPDGAPEEIYVVPPVNPDVTIVHAQRADRSGNTQVWGLTGVQAEAVYAAKKAVVVVEEIVEDEVVRSDPNRTVIPSHAVHAVVACPRGAHPSFAQGYYDRDNAFYRSWSHISKDPARLRDWMAEWVYGTRDHAEYVAKQGEGFWAGLAVGEAMSLPVNYGRRL
>NZ_CP011340.1|WP_037775954.1|1327302_1328073_-|3-oxoadipate--succinyl-CoA-transferase
MTAAGTATSSELLSVVASRELAGRRTVFAGIGLPTLAASLAHLTVAPQLEIVYESGVCGAHPSHLPETIADAVLITGAEAVLSMATLFGSVLQGGHIDVGFLGAAQIDRHGNLNSSVIGDWDRPKVRLPGSGGAMEVMANSGEVFVVMRRHDPRSFMADLDFCTSPGPDRALADGITPRGAGVTRVITDLGILAREGVGEELRLVAVHPGVTVDRVRAATGWDLQVADEVTTVEPPTAAELRLLREDVDPGRVYLR
>NZ_CP011340.1|WP_005309195.1|1325653_1327183_-|3-hydroxyacyl-CoA-dehydrogenase
MRIRVVGAGVMGRGIAQWAVTAGHTVELADARPEAVDEAVGFVSGMLGRAVEKGRTSAEDAAAAVERLVPLRSPLAPGDGVDLVVEAVLEDLAVKTELFTGLEKVLPASAVLATNTSSLSVTRIAAGLTDPSRLAGLHFFNPVPLMRIAEVVPGAATRPGVVPFLVDLVEKSGHRAVVVADTPGFLVNHAGRGLITEALALLEEDVADAAGIDRIARDVLGLRMGPFELTDLTGLDVTASVIDTVWQGFRHSERLRPSYLTPNRVAAGLHGRKTGRGFYEHGPGAPVAPAEPPVTGDAARPVHVPGDAPDAQEVRRVLRAEGAVLDEGARPGDRCVVLVPVWGTTVAEAVAELGLPAGRTLGVDPLSLGARRRVLAMTPASDPNAVRDARAVLARSGEAAVPVSVVRDTAGSVAQRLLASMVSVAASIAERAIAAPADIDLAVTAGLGYPHGPLAWGDRIGAARMLALHRALYGTTGDPRYRPTRWVTERARLGLPLTEAGAPPPHAAR
>NZ_CP011340.1|WP_158685135.1|1325058_1325565_+|hypothetical-protein
MTATRRSPWRMIGLALVLSAATGAGLLALVAREFDAGDCADAAARTEQVASLRVFDMPPPGARPSRGWEEAESECLDDSGEAWLAVTWQYDWGASRQSVMDHYRAAAGEDGWSVEPPDGGAGVPLGPADVCYAKDIEGGPVLLRIFFDTPGAFVVSVESSLDGTPMGC
>NZ_CP011340.1|WP_053556733.1|1323584_1324856_+|ROK-family-protein
MNGNHSGSTRAGTGGRTPMEPKADRETVRRHNLSLVLRTVRDQVEATRAGVAARVGLTRAAVSSLVEQLIESGFLSESGKTFSGQAGRPGTVLKVARTGLAGIGVEINVDYVAVCVVDLAGTDRVRLVEHLDNRGAAPAEVFGRAARIAARALASATEQELRPVGAELALPGLISGGSVLQAPNLGWTSVPAEAPFAEALAALLPGPPALPVRSENEANLAALAELWFGGLGDVRSFLYLTGEIGVGGALVLDGELLRGANGFAGEIGHVSVSDDGPLCRCGSRGCLEQYAGQAALLRAAGLDERAGAAGMAELEHRARAGDDAALAALAGAGRALGRALSGAVNLFDPDAVVLGGVYRPLMPWLGPPTGAELEARVVSGLWSPTSARLRASSPAADAARGAAALVVQDVLADPVAYAPRPSA
>NZ_CP011340.1|WP_053556735.1|1336188_1337664_-|xylulokinase
MPANAVVIGVDSSTQSTKAAFTDVTSGRLLAVGRASHRVTGEHGARETDPEVWWQALADAVAAGLKELAGLGIEPAAVTGIAVAGQQHGLVVLDRAGAPVRPALLWNDTRSAPQAAALTEALGGPDAWTARTGSVPVASMTAAKWQWLRQNEPAAADAAAAVRLPHDFLTERLSGVAATDPGDASGTCWYSTATGAYDPALLDLVGLDQALLPTVAPTGATRVGSLTPAAAERLGLPAGIAVAAGTGDNMAAAVGLGLGGAGLLDHPALSLGTSGTVFAASRTRPASPALAGFAAADGTYLPLACTLNCTLAVDKVASLLGLDREAAEAGGEVVLLPYLDGERTPDLPGASGMLSGLRHTTTRQQILGAAYEGAAVTVLRALDEVMRACGQDPADPATAARPLRLVGGGANGRHWVETVRRLSGRPLLIPSSGELVALGASALAAAAATGADPVALAAEWEGGSGTELEAVERDMETWERVSAAVEEAAAG
>NZ_CP011340.1|WP_005309204.1|1337832_1339002_+|xylose-isomerase
MTERFTPTPDDKFSFGLWTVGWQGRDPFGDATRPHLDPAESVRRLADLGAYGVTFHDDDLIPFGSSDSEREAHIKRFREALDATGVIVPMATTNLFTHPVFKDGGFTANDRDVRRYALRKTIRNIDLAVELGAQTYVAWGGREGAESGGAKDVRVALDRMKEAFDLLGEYVTEQGYDLRFAIEPKPNEPRGDILLPTVGHALAFIERLERPELYGVNPEVGHEQMAGLNFPHSIAQALWAGKLFHIDLNGQSGIKYDQDLRFGAGDLRSAFWLVDLLETAGYAGPRHFDFKPPRTEDFDGVWESAAGCMRNYLILKERAAAFRSDPEVQEALRASRLDELARPTAEDGLAALLADRTAFEDYDVDAAAERGMAFERLDQLAMDHLLGAR
>NZ_CP011340.1|WP_106428394.1|1339056_1339551_-|ATP-binding-protein
MERAPSPAHGRAGPTSALRGLAHCAMPATPEAARALRRFARAVARRWRLAEHFDEALSVIVTELVTNVVLHSGSPWVSTVISVRGDALTVEVMDGGCWKHRVTRRQEPLDADVPCGRGLRLVDAYATRTMTHRMERGSVVLAEIELHTRPPFVRDPLQAFDPHL
>NZ_CP011340.1|WP_078951208.1|1339560_1342533_+|AAA-family-ATPase
MGSCSVGRHRPDSGPAAGESFSNLAVESHAGVLRQPQHSYPDTSRSIRDTETRIRKESKCLGISEESDSVVTWSDETAGRWSERVLGGPSADEAALLLVEGPAGTGKTRLAARLVDGAAARSIRSVTVSFSSSGATVVSRPRPGTSERPPGSAPPSPADLPGALAPLLERGDRFLLVAEDVHRADGPALELLRRLLDRPPARLAAVVTYRPEELPEPGLALGRGAHFPSSLAVSRLRLGPLDAQQVRELVEEGLGPSRCPSDLVTRVQERSGGVPQVVADVVRLLCESGDGRERYSVRDLEAAGVPPRLAELALGRTAALTERARPVAWAAAVLDEPVEAGELSAVAGLDGGEGTKALVEALRAGVLREDAEGRYGFFVPMAATAVYGQVPGPVRREMHRRAATALGRRHPVPWVPLARHRRHGGQTKAWLRAVEHAALQCAADGEHQAAIDILERALSRPTVPPAARARLAPLLAHSAVLGLRSDQTVTVLRQILDEQSLPAAVRGQIRLDLGLLLCNQAVAGMQGWLELQKAVEELEERPLMAARAMAALAMPLLSTVPLERNLYWLERAEKAGADSGDEEARTAVAANRAGTLMYIGDPAAWQVLEQLPRDTEDAACRQHVARGLCNAADGALWLGQLGPARGLLAEGVALATRSGASYVEQGARGTSLLLDWAEGDWAELTGRARAFVAEADTMPGQGVDGRTVLGLMAISRGEWQQATAWLAGDGSRQTEGSAVPHVATASGALIRMALVRDDVETAVAEASTAWDRIRDKGVWVWAAELAPWAVDAMLRAGRRDTAQGMIAEYEAGLDGRQAPASSAALDWCRALLAEADGDPRTGADLYRRAALEYAGIPRPYATVLATEGAARCQLASGTDAAAVVAELTSCVEQLTELGAVWDAARLRAELRAHQPADEQRPRGRPSYGDRLSPREQEVADLAATGLTNREIAATLHLSPRTVEQHVSRARRKLESQSRQNLSRTRAQRPE
>NZ_CP011340.1|WP_053556737.1|1342835_1343882_-|putative-sulfate-exporter-family-transporter
MALLRDRPAAPPQARAGGTRRRGLALAALGVALAWSVHRILPGVPMLTAAVVLGVAAAHLPRLRATVRGPARPGLSYAGRRLMRAGIVLLGLRLGLDDVRGLGWATVAMVIGVVTATLLGTWWLGRRLGLPGDQPLLIATGYAVCGASAIGAVGEVRDSDERDAATSVALVTLCGTLAIAVLPLLQGPLGLGDAEFGRWAGASVHDVGQVVATAQTAGDAALGEAVLVKLMRVALLGPLVAVVALAARRGNKGTQGASGARRVPLVPLFVVGFLAAVALRSTGLLPPGVLEGAHVTQELLLAAALFGLGSAVDLPSLTRTGGRVAALGLSAWLVVAGLSYAGVLLQAA
>NZ_CP011340.1|WP_053556738.1|1343881_1344463_-|cysteine-dioxygenase
MTPAPTAQSASSAPRTTDRLDALVAGVREVVGRGLPPDPTAYLVGERLAPHLGAPDLLTAEQRQSDTDRYRQHLLHAEHDGSFSVVALVWLPGQGTSVHDHVSWCTTGVHEGREQERRYRLVPAARADGAARLVATADVVSEQGEFCGFAPPGDIHRVWNPGPSTAVSLHVYGADISRLGSSVRRVYALPADR
>NZ_CP011340.1|WP_005309207.1|1344559_1345465_-|LysR-family-transcriptional-regulator
MFDSRHIKTFHEVVRTGSYTAAARALGYTQPAVTQQMKALERDVGSPLFVRVGRGMRLTEAGEALSRHATAILDSMSAAQEQMNALTRLRAGRVRLCAFPSANSTLVPETLARLTAEHPAIRVDLLENEPPESLRRLARGECDISLAFTYPGLHEDVPEELVEIPLLEDQLTVLLPGGHHLARRRVVRLTDLAGERWIAGCPRCRANLLHECAEAGFVPDIAFMTDDNLAVQSLVAEGLGVAMIPALVLNFMRHAKVAGRPLQPASRRKISAYVLKEHLRIPATALVLDELRTVAANKTGC
>NZ_CP011340.1|WP_005309208.1|1345605_1346418_-|SAM-dependent-methyltransferase
MTGTEPAAARIDTSRPHPARVYDWFLGGKDNYPVDEELGRQIMGVDGTARHVARTNRWFMQRVTRWLAGEAGIRQFLDIGTGIPTEPNLHQVAQGIAPDARIVYTDNDPIVLIHAEALLRSSREGITDYVQADVREPGRILEQARKNLDLTRPVALSLVALTHFLGDEDRPYDLVARLVDALPSGSYLVLSQLTADFDPVAVGRGVAMYAAGGVTLAPRTKDEIARFFDGLDTVDPGLVQLTDWHPELAVGESVDENAVISLYGAVARKP
>NZ_CP011340.1|WP_005309209.1|1346740_1347211_+|cation:proton-antiporter-regulatory-subunit
MTTRRTPLPGVGIQYDFSTESGHHVSVVVHNDGRRFLGFYSADDPDACLLSVPLVPEEATALAHLLDQAPIDAVRTDGIDLVTEHIPVGVRSPYVGRALGDTGARTRTGASIVAVLRRTGAHPSPGPGFRLATGDTLVAVGTREGVDTLAEIIAGG
>NZ_CP011340.1|WP_005309211.1|1349295_1349511_-|hypothetical-protein
MAHRISTLISAFGVFVAAMLLIGAVVEYRAGASALWVAFGVLILVSAVYTLVRDIRRPRPRWRPRRPAADE

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Crispr_ID: NZ_CP011340_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_4

1345534-1345626

Orphan

Consensus_repeat	Method
CCGGCTACGGCTTGCGGGCCACCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_4

>merge|NZ_CP011340|4|1345534-1345626|CRISPRCasFinder
CCGGCTACGGCTTGCGGGCCACCGCGCCGTACAGAGAGATCACCGCGCACTCACCGACCGTTTCCGGCCCGGCTACGGCTTCCGGGCCACCGC

>NZ_CP011340|4|4|1345534-1345626|CRISPRCasFinder
CCGGCTACGGCTTGCGGGCCACCGC	GCCGTACAGAGAGATCACCGCGCACTCACCGACCGTTTCCGGC
CCGGCTACGGCTTCCGGGCCACCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_005309201.1\|1333653_1335006_+\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NZ_CP011340.1\|WP_078951208.1\|1339560_1342533_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|197715
NZ_CP011340.1\|WP_053556735.1\|1336188_1337664_-\|xylulokinase	unknown	unknown	gnl\|CDD\|198375
NZ_CP011340.1\|WP_053556737.1\|1342835_1343882_-\|putative-sulfate-exporter-family-transporter	unknown	unknown	gnl\|CDD\|225411
NZ_CP011340.1\|WP_005309207.1\|1344559_1345465_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NZ_CP011340.1\|WP_053556738.1\|1343881_1344463_-\|cysteine-dioxygenase	unknown	unknown	gnl\|CDD\|380416
NZ_CP011340.1\|WP_005309202.1\|1335025_1335487_+\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|239534
NZ_CP011340.1\|WP_005309204.1\|1337832_1339002_+\|xylose-isomerase	unknown	unknown	gnl\|CDD\|237170
NZ_CP011340.1\|WP_005309219.1\|1357239_1357791_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|183800
NZ_CP011340.1\|WP_005309217.1\|1354058_1355720_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|224423
NZ_CP011340.1\|WP_005309209.1\|1346740_1347211_+\|cation:proton-antiporter-regulatory-subunit	unknown	unknown	gnl\|CDD\|223564
NZ_CP011340.1\|WP_037775961.1\|1350333_1351272_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381391
NZ_CP011340.1\|WP_106428394.1\|1339056_1339551_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NZ_CP011340.1\|WP_037773229.1\|1353045_1353948_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133378
NZ_CP011340.1\|WP_037773231.1\|1356020_1357172_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP011340.1\|WP_005309215.1\|1351775_1352516_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|380093
NZ_CP011340.1\|WP_005309212.1\|1349620_1350106_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005309200.1\|1332130_1333354_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|235741
NZ_CP011340.1\|WP_005309214.1\|1351296_1351647_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133384
NZ_CP011340.1\|WP_005309211.1\|1349295_1349511_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_005309201.1\|1333653_1335006_+\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.22738e-146
NZ_CP011340.1\|WP_078951208.1\|1339560_1342533_+\|AAA-family-ATPase	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	6.54913e-16
NZ_CP011340.1\|WP_053556735.1\|1336188_1337664_-\|xylulokinase	gnl\|CDD\|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	1.79554e-136
NZ_CP011340.1\|WP_053556737.1\|1342835_1343882_-\|putative-sulfate-exporter-family-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	7.38827e-63
NZ_CP011340.1\|WP_005309207.1\|1344559_1345465_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.59748e-61
NZ_CP011340.1\|WP_053556738.1\|1343881_1344463_-\|cysteine-dioxygenase	gnl\|CDD\|380416	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain. This family contains cysteine dioxygenase (CDO; EC 1.13.11.20), which catalyzes the conversion of cysteine to cysteine sulfinic acid, the first step in the biosynthesis of essential oxidized cysteine metabolites such as sulfate, hypotaurine, and taurine. CDO also plays an important role in the regulation of intracellular cysteine levels in mammals; CDO expression is altered in cancer cells, and abnormal or deficient CDO activity has been linked to Parkinson's disease, Alzheimer's disease, and rheumatoid arthritis. CDO is an iron-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate cysteine sulfinic acid. The CDO active site contains an amino acid-derived cofactor. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	9.56939e-31
NZ_CP011340.1\|WP_005309202.1\|1335025_1335487_+\|MaoC-family-dehydratase	gnl\|CDD\|239534	cd03450, NodN, NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their legume hosts, a symbiotic process that requires production of Nod factors, which are signal molecules involved in root hair deformation and meristematic cell division. The nodulation gene products, including NodN, are involved in producing the Nod factors, however the role played by NodN is unclear.	1.92912e-75
NZ_CP011340.1\|WP_005309204.1\|1337832_1339002_+\|xylose-isomerase	gnl\|CDD\|237170	PRK12677, PRK12677, xylose isomerase; Provisional.	0
NZ_CP011340.1\|WP_005309217.1\|1354058_1355720_+\|alpha/beta-hydrolase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	4.35195e-08
NZ_CP011340.1\|WP_005309209.1\|1346740_1347211_+\|cation:proton-antiporter-regulatory-subunit	gnl\|CDD\|223564	COG0490, COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism].	5.34147e-39
NZ_CP011340.1\|WP_037775961.1\|1350333_1351272_+\|aldo/keto-reductase	gnl\|CDD\|381391	cd19752, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	5.71784e-139
NZ_CP011340.1\|WP_106428394.1\|1339056_1339551_-\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	6.64103e-11
NZ_CP011340.1\|WP_037773229.1\|1353045_1353948_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	3.50028e-23
NZ_CP011340.1\|WP_037773231.1\|1356020_1357172_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.95358e-59
NZ_CP011340.1\|WP_005309215.1\|1351775_1352516_-\|VOC-family-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	6.32373e-26
NZ_CP011340.1\|WP_005309200.1\|1332130_1333354_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|235741	PRK06205, PRK06205, acetyl-CoA C-acetyltransferase.	0
NZ_CP011340.1\|WP_005309214.1\|1351296_1351647_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133384	cd01109, HTH_YyaN, Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB. Putative helix-turn-helix (HTH) MerR-like transcription regulators of Bacillus subtilis, YyaN and YraB, and related proteins; N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	3.12337e-40
NZ_CP011340.1\|WP_005309219.1\|1357239_1357791_+\|hypothetical-protein	gnl\|CDD\|183800	PRK12863, PRK12863, YciI-like protein; Reviewed.	2.42149e-20

>NZ_CP011340.1|WP_005309207.1|1344559_1345465_-|LysR-family-transcriptional-regulator
MFDSRHIKTFHEVVRTGSYTAAARALGYTQPAVTQQMKALERDVGSPLFVRVGRGMRLTEAGEALSRHATAILDSMSAAQEQMNALTRLRAGRVRLCAFPSANSTLVPETLARLTAEHPAIRVDLLENEPPESLRRLARGECDISLAFTYPGLHEDVPEELVEIPLLEDQLTVLLPGGHHLARRRVVRLTDLAGERWIAGCPRCRANLLHECAEAGFVPDIAFMTDDNLAVQSLVAEGLGVAMIPALVLNFMRHAKVAGRPLQPASRRKISAYVLKEHLRIPATALVLDELRTVAANKTGC
>NZ_CP011340.1|WP_053556738.1|1343881_1344463_-|cysteine-dioxygenase
MTPAPTAQSASSAPRTTDRLDALVAGVREVVGRGLPPDPTAYLVGERLAPHLGAPDLLTAEQRQSDTDRYRQHLLHAEHDGSFSVVALVWLPGQGTSVHDHVSWCTTGVHEGREQERRYRLVPAARADGAARLVATADVVSEQGEFCGFAPPGDIHRVWNPGPSTAVSLHVYGADISRLGSSVRRVYALPADR
>NZ_CP011340.1|WP_053556737.1|1342835_1343882_-|putative-sulfate-exporter-family-transporter
MALLRDRPAAPPQARAGGTRRRGLALAALGVALAWSVHRILPGVPMLTAAVVLGVAAAHLPRLRATVRGPARPGLSYAGRRLMRAGIVLLGLRLGLDDVRGLGWATVAMVIGVVTATLLGTWWLGRRLGLPGDQPLLIATGYAVCGASAIGAVGEVRDSDERDAATSVALVTLCGTLAIAVLPLLQGPLGLGDAEFGRWAGASVHDVGQVVATAQTAGDAALGEAVLVKLMRVALLGPLVAVVALAARRGNKGTQGASGARRVPLVPLFVVGFLAAVALRSTGLLPPGVLEGAHVTQELLLAAALFGLGSAVDLPSLTRTGGRVAALGLSAWLVVAGLSYAGVLLQAA
>NZ_CP011340.1|WP_078951208.1|1339560_1342533_+|AAA-family-ATPase
MGSCSVGRHRPDSGPAAGESFSNLAVESHAGVLRQPQHSYPDTSRSIRDTETRIRKESKCLGISEESDSVVTWSDETAGRWSERVLGGPSADEAALLLVEGPAGTGKTRLAARLVDGAAARSIRSVTVSFSSSGATVVSRPRPGTSERPPGSAPPSPADLPGALAPLLERGDRFLLVAEDVHRADGPALELLRRLLDRPPARLAAVVTYRPEELPEPGLALGRGAHFPSSLAVSRLRLGPLDAQQVRELVEEGLGPSRCPSDLVTRVQERSGGVPQVVADVVRLLCESGDGRERYSVRDLEAAGVPPRLAELALGRTAALTERARPVAWAAAVLDEPVEAGELSAVAGLDGGEGTKALVEALRAGVLREDAEGRYGFFVPMAATAVYGQVPGPVRREMHRRAATALGRRHPVPWVPLARHRRHGGQTKAWLRAVEHAALQCAADGEHQAAIDILERALSRPTVPPAARARLAPLLAHSAVLGLRSDQTVTVLRQILDEQSLPAAVRGQIRLDLGLLLCNQAVAGMQGWLELQKAVEELEERPLMAARAMAALAMPLLSTVPLERNLYWLERAEKAGADSGDEEARTAVAANRAGTLMYIGDPAAWQVLEQLPRDTEDAACRQHVARGLCNAADGALWLGQLGPARGLLAEGVALATRSGASYVEQGARGTSLLLDWAEGDWAELTGRARAFVAEADTMPGQGVDGRTVLGLMAISRGEWQQATAWLAGDGSRQTEGSAVPHVATASGALIRMALVRDDVETAVAEASTAWDRIRDKGVWVWAAELAPWAVDAMLRAGRRDTAQGMIAEYEAGLDGRQAPASSAALDWCRALLAEADGDPRTGADLYRRAALEYAGIPRPYATVLATEGAARCQLASGTDAAAVVAELTSCVEQLTELGAVWDAARLRAELRAHQPADEQRPRGRPSYGDRLSPREQEVADLAATGLTNREIAATLHLSPRTVEQHVSRARRKLESQSRQNLSRTRAQRPE
>NZ_CP011340.1|WP_106428394.1|1339056_1339551_-|ATP-binding-protein
MERAPSPAHGRAGPTSALRGLAHCAMPATPEAARALRRFARAVARRWRLAEHFDEALSVIVTELVTNVVLHSGSPWVSTVISVRGDALTVEVMDGGCWKHRVTRRQEPLDADVPCGRGLRLVDAYATRTMTHRMERGSVVLAEIELHTRPPFVRDPLQAFDPHL
>NZ_CP011340.1|WP_005309204.1|1337832_1339002_+|xylose-isomerase
MTERFTPTPDDKFSFGLWTVGWQGRDPFGDATRPHLDPAESVRRLADLGAYGVTFHDDDLIPFGSSDSEREAHIKRFREALDATGVIVPMATTNLFTHPVFKDGGFTANDRDVRRYALRKTIRNIDLAVELGAQTYVAWGGREGAESGGAKDVRVALDRMKEAFDLLGEYVTEQGYDLRFAIEPKPNEPRGDILLPTVGHALAFIERLERPELYGVNPEVGHEQMAGLNFPHSIAQALWAGKLFHIDLNGQSGIKYDQDLRFGAGDLRSAFWLVDLLETAGYAGPRHFDFKPPRTEDFDGVWESAAGCMRNYLILKERAAAFRSDPEVQEALRASRLDELARPTAEDGLAALLADRTAFEDYDVDAAAERGMAFERLDQLAMDHLLGAR
>NZ_CP011340.1|WP_053556735.1|1336188_1337664_-|xylulokinase
MPANAVVIGVDSSTQSTKAAFTDVTSGRLLAVGRASHRVTGEHGARETDPEVWWQALADAVAAGLKELAGLGIEPAAVTGIAVAGQQHGLVVLDRAGAPVRPALLWNDTRSAPQAAALTEALGGPDAWTARTGSVPVASMTAAKWQWLRQNEPAAADAAAAVRLPHDFLTERLSGVAATDPGDASGTCWYSTATGAYDPALLDLVGLDQALLPTVAPTGATRVGSLTPAAAERLGLPAGIAVAAGTGDNMAAAVGLGLGGAGLLDHPALSLGTSGTVFAASRTRPASPALAGFAAADGTYLPLACTLNCTLAVDKVASLLGLDREAAEAGGEVVLLPYLDGERTPDLPGASGMLSGLRHTTTRQQILGAAYEGAAVTVLRALDEVMRACGQDPADPATAARPLRLVGGGANGRHWVETVRRLSGRPLLIPSSGELVALGASALAAAAATGADPVALAAEWEGGSGTELEAVERDMETWERVSAAVEEAAAG
>NZ_CP011340.1|WP_005309202.1|1335025_1335487_+|MaoC-family-dehydratase
MAPFIADGIPEISALAGRDLGHSRWREVTQDLIDMFAAVSGDHQWIHTDTERAAQGPYGGTIAHGYMVLSWGIPMFAELLQVTGVGMALNYGVNKVRFPAPVPVGSRVRLHATVTSVAPVKRGGVGMTRAFTFELEGSAKPACVAESLTHVYP
>NZ_CP011340.1|WP_005309201.1|1333653_1335006_+|MHS-family-MFS-transporter
MSASTAREQKRTANRAGLGAFIGSTIEWFDFYIYGTAAALVFDEVFFPELEGPLGTLVAFATFWVGFLARPLGGIIFGHFGDRLGRKKTLVITLLMMGIATTLIGLLPGYSSIGVAAPILLVCIRMVQGIGLGGEWGGSVLIASEHAPKGKSILYGAFAQQGSPVGNTLSTISFLAISQLPNDAFVSWGWRIPFLASAVLVFVGLFVRMRVAESPAMAKAIRTKNVSKLPLTEVLRTQPTLILLGIGACTIGLSATYFKSTFALSWATSSLDFDRSSFLTIILVANVLQVLVQPFGAVLATRMKSMTRAVCVMLLPEIFLLPLMFVLIGTENYTLAMIGVSVATIPHCLYYAALAGMLASRFPANVRYTGISLCYQLCGTILGGTTPIVGQSLLNWTGSITAVIIYAVFQVLLTLGCMVLILRRPNHDELADDPAEQPAPGTTATVTTTV
>NZ_CP011340.1|WP_005309200.1|1332130_1333354_+|acetyl-CoA-C-acetyltransferase
MSGQPDVVICEPLRTPIGRFGGALSSLRPAALAAHVIAEVVRRTGIDPGQVDEVILGHAYPTSDAPAIGRVAALDAGLPVSVTGVQVDRRCGSGLQAVLDAAMQIRAGFSDVVIAGGVEVMSAAPYYTHDGRWGIKGPGLQLHDSLARGRVTAGGVNHPVPGGMIETAENLRREYGISREDQDALALRSQQRAGRAMETGLFGDEIVPVPVRGRKGETLVSADEHPRPDTTAEKLASLRPLTIGSDPEATVTAGNASGQNDAAAACLVTSAETAARLGLTPMVRLVSFARAGVPAGTMGIGPVPATRAALERAGLKLADLDLIELNEAFAAQVLACTRELGLSEADHERINVNGSGISLGHPVGATGGRILATLAHEMRRREARYGLETMCIGGGQGLAAVFERVTA
>NZ_CP011340.1|WP_005309209.1|1346740_1347211_+|cation:proton-antiporter-regulatory-subunit
MTTRRTPLPGVGIQYDFSTESGHHVSVVVHNDGRRFLGFYSADDPDACLLSVPLVPEEATALAHLLDQAPIDAVRTDGIDLVTEHIPVGVRSPYVGRALGDTGARTRTGASIVAVLRRTGAHPSPGPGFRLATGDTLVAVGTREGVDTLAEIIAGG
>NZ_CP011340.1|WP_005309211.1|1349295_1349511_-|hypothetical-protein
MAHRISTLISAFGVFVAAMLLIGAVVEYRAGASALWVAFGVLILVSAVYTLVRDIRRPRPRWRPRRPAADE
>NZ_CP011340.1|WP_005309212.1|1349620_1350106_+|hypothetical-protein
MADLLWDDVKCFFDPDLMGALPDVRVPGASVEDWQAILDLVAERGWECQYSEGETEVPLPRAEVVLSRAADAEWPSLRVRPAAEFLAIFRFHADDEVDFDVDLRELQGQERLDVFCDFLRAIGRRLGKPVLMDPEGDCGHPVLGFDVEADQVVLLAEPLVT
>NZ_CP011340.1|WP_037775961.1|1350333_1351272_+|aldo/keto-reductase
MNTTDPQIVLGTMDFGTRVGPDHAFAILDSFVAGGGVWLDTANCYSFWTDPSGVGGASERLIGAWLRARPGARDRVRIATKVRHNPLVPHSWPESAEGLSARAVRAGIEESLERLRVDHIDMLWAHAEDRTVPLEETVGAFGELVTKGVALRVGAANHAAWRVERARSLAREQGVEPWTALQLRHSLVQPRPLAPVAEGGHRMLTAEDLDLAQSEGLTVWSYSTLLWGSYVRPDKPFPPTYAHPGTTRVLAVLDDVAGELSATRNQVVLAWLMRQGIDPIVGASRVEHIEQALAARRVRLSDEHLARFEQAR
>NZ_CP011340.1|WP_005309214.1|1351296_1351647_+|MerR-family-transcriptional-regulator
MTTTLTPAAAADRTGVSIDTLRYYEREGLIGPIRRSPGGRREYTEEDVFWIGLVTCFREAGLGIADLRAFVAILRAEHAAQDRVAFLRERRAALERQAAALSRAMEVLDEKIAYYS
>NZ_CP011340.1|WP_005309215.1|1351775_1352516_-|VOC-family-protein
MALRPVMANIKALDCPAVGRFWAEALGWSAYSPGVTTYVGPVGGLVWPDPVALGIDIVPVPEPRTPTKNRVHLDIATNSAAQQTELVARLLALGATPADVGQGEVPWTVLADPEGNEFCVLEPREIYRDTGPVARVVVDCADPRAMARFWDEALDWTLHEVTDDHAVLRSAKGVGPYLEFLRTPDAKTAPDRVHLDLLPYAGDDKAAEVARLRALGATDLDLGQGDVPWTCLADPEGHEFCVLAPS
>NZ_CP011340.1|WP_037773229.1|1353045_1353948_-|MerR-family-transcriptional-regulator
MWSIGELAEHAGLTVKTVRFYSDRGLLPEAARSSGGHRRYGFEAIERLRLIRSLRTLDLPVPDVGRVLDEEDALEDVVAGQLREIGTRMTALRWREAALRLLQDCTPEERVDRLRLIGSVTTPPSTAALARFWRRWLPVRLPARVVSAVVEQAVPQPPSDPAPAQVLAFARLHALVSGPCHGNENCQPTVHQPDTGYRPAVLYDGLGEAYALAARQMLAQRPPQPGEALDCFVAAYAHSCGTRDTPDFRRLLAGQLAADPRIDRYWRLAADLFGPSQPTPGAAHDWLCAALDPRTAGASA
>NZ_CP011340.1|WP_005309217.1|1354058_1355720_+|alpha/beta-hydrolase
MTVFILVSDAFTGGWIWRDVAAGLREAGAEVHPVTLTGMGDRRHLAGPGTDLETHVQDLVQLIDHLDPAPAKTAEAEDSADSVVSMGSATPVEPAAPDLVLVGHGYGIHPVLGAADRRPERVARIVHLDAGMPQDGDAAVALVPDRTVHELLTDRAHETGTTAEGAAESGAESGAGAGAEDRLIPPPPAGEWQRLGSTAGVPADALARLARLAAPQPTGTLTRPLRLSGALSGVPTTGVLCTANGSSIAMVEALVGLGDPRLRVLTEPQVTFFELDTGHWPMLSTPGELAEVLRRAAAGEGHRISPSVSEQPAHLRPFLIDVPERPRERTGRVDLYLPDADEPRPAVVFVHGGPVSAEARPTPRDWPAFVGYGSYVASLGAVGVTLDHRLHGLADYGRAAEDVAEAVELVRADPRVDGERVALWFFSGGGLLSADWLAAPPAWLRCVAATYPVLAPLPNWPLADSRFLPAATVRKAGQLPFVLTRVELEGPEIAATVEEFLTAAEECDAAVEIIDVPQGHHAFETIDHTEEARDAVARAARSVLGHLRGDLLG
>NZ_CP011340.1|WP_037773231.1|1356020_1357172_+|serine-hydrolase
MTNLHNVLSDHVDTESLPGAVALVARGDQVDVQAVGHVDAERTAPMARDTIFRVASITKPVVAAAVMMLVEDGRITLDDPVGTWLPELAAPMVVRTPDSPVDDVVPAARPITVFDLLTSRAGYGFPSDFSLPAVEPLVRELKQGPPQPQAVPPTDEWMAALSRIPMLYQPGEAWLYNICSDIQGVLIARVSGSSLPDFLAERLFEPLGMTDTAFAVPPAKLDRFTSYYRVDPMGALELADTPDGEWSTPPAFPSGAGGLVSTADDYHAFARMLLGRGATGSGGRLLSAGSVERMTTNYLTPAQRKAGGLFLEGMGWGFGGAVDVEAVEPWSVPGRYGWVGGTGTAMHITPSTGAVTIFLTQLQMSGPSFPEPMRDFWVYAAGV
>NZ_CP011340.1|WP_005309219.1|1357239_1357791_+|hypothetical-protein
MEFFCYHRDRPGSLPLRHELLEEHWSYMDGFEKEMIARGPTMTSDGDTPTGSVHVVDLPDPAAAHAFAFGEPGYQAGVYRDVLVRRWRNLLDRTMWDFPGGRTGGNRYLVLGFGSGPGADLAVPQVGDDLIAYGPLLSDDGTAWLGTALLVRAPDPDAARAVLTVGAYDGIEVHKWQFGGRSA

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Crispr_ID: NZ_CP011340_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_5

1901021-1901192

Orphan

Consensus_repeat	Method
CCCCGAACCGGGCCACGCCCGG	CRT

3 spacers

The CRISPR arrays of NZ_CP011340_5

>merge|NZ_CP011340|5|1901021-1901192|CRT
CGCCGAACCGGGCCACGCCCGGAAAAGCCGCACACGAACGGCGTCGCCCCCCGGACCGGGCCACGCCCGGGACCGCCGCACCCGGACCCGTCCGGGCGGCACCCCGAACCGGGCCACGCGCGGACGCGCCGCGCCCCAAGGGCCTCACGCTCACGACCCGGGCCACGCCCGG

>NZ_CP011340|5|1|1901021-1901192|CRT
CGCCGAACCGGGCCACGCCCGG	AAAAGCCGCACACGAACGGCGTCGCC
CCCCGGACCGGGCCACGCCCGG	GACCGCCGCACCCGGACCCGTCCGGGCGGCA
CCCCGAACCGGGCCACGCGCGG	ACGCGCCGCGCCCCAAGGGCCTCACGC
TCACGACCCGGGCCACGCCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_005310195.1\|1899351_1900344_+\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224296
NZ_CP011340.1\|WP_005310203.1\|1903489_1904536_-\|PHP-domain-containing-protein	unknown	unknown	gnl\|CDD\|236135
NZ_CP011340.1\|WP_037773424.1\|1888196_1889042_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|378676
NZ_CP011340.1\|WP_053556813.1\|1900361_1900847_+\|DUF456-domain-containing-protein	unknown	unknown	gnl\|CDD\|377293
NZ_CP011340.1\|WP_053556811.1\|1886063_1887254_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005310209.1\|1906143_1907418_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238733
NZ_CP011340.1\|WP_005310189.1\|1890467_1890905_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP011340.1\|WP_037773422.1\|1887284_1888046_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP011340.1\|WP_158685145.1\|1909905_1910214_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_037776117.1\|1889237_1890308_+\|DUF2637-domain-containing-protein	unknown	unknown	gnl\|CDD\|378511
NZ_CP011340.1\|WP_078951226.1\|1893105_1895289_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP011340.1\|WP_053556812.1\|1895424_1899165_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173812
NZ_CP011340.1\|WP_005310191.1\|1891225_1892968_-\|pyruvate-dehydrogenase	unknown	unknown	gnl\|CDD\|180614
NZ_CP011340.1\|WP_037773430.1\|1909039_1909729_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_CP011340.1\|WP_005310217.1\|1910414_1910897_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005310205.1\|1904868_1905306_+\|alkaline-protease-inhibitor	unknown	unknown	gnl\|CDD\|366264
NZ_CP011340.1\|WP_005310211.1\|1907645_1908056_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380361
NZ_CP011340.1\|WP_005310199.1\|1901296_1902415_-\|ribosome-small-subunit-dependent-GTPase-A	unknown	unknown	gnl\|CDD\|234988
NZ_CP011340.1\|WP_037773429.1\|1905358_1906144_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_078535475.1\|1902904_1903477_+\|LysE-family-transporter	unknown	unknown	gnl\|CDD\|280058

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_005310195.1\|1899351_1900344_+\|LuxR-family-transcriptional-regulator	gnl\|CDD\|224296	COG1378, COG1378, Predicted transcriptional regulators [Transcription].	8.74646e-14
NZ_CP011340.1\|WP_005310203.1\|1903489_1904536_-\|PHP-domain-containing-protein	gnl\|CDD\|236135	PRK07945, PRK07945, PHP domain-containing protein.	0
NZ_CP011340.1\|WP_037773424.1\|1888196_1889042_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|378676	pfam11575, FhuF_C, FhuF 2Fe-2S C-terminal domain. This family consists of several bacterial ferric iron reductase protein (FhuF) sequences. FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. This domain is the C-terminal domain that contains 4 conserved cysteine residues that are found to be part of a 2Fe-2S cluster.	1.8234e-05
NZ_CP011340.1\|WP_053556813.1\|1900361_1900847_+\|DUF456-domain-containing-protein	gnl\|CDD\|377293	pfam04306, DUF456, Protein of unknown function (DUF456). This family is a putative membrane protein that contains glycine zipper motifs.	1.34926e-16
NZ_CP011340.1\|WP_037773430.1\|1909039_1909729_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	8.58525e-55
NZ_CP011340.1\|WP_005310209.1\|1906143_1907418_-\|VWA-domain-containing-protein	gnl\|CDD\|238733	cd01456, vWA_ywmD_type, VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the members of this subgroup. All members of this subgroup however have a conserved MIDAS motif. .	1.72397e-44
NZ_CP011340.1\|WP_005310189.1\|1890467_1890905_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.23826e-15
NZ_CP011340.1\|WP_037773422.1\|1887284_1888046_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	6.19709e-35
NZ_CP011340.1\|WP_037776117.1\|1889237_1890308_+\|DUF2637-domain-containing-protein	gnl\|CDD\|378511	pfam10935, DUF2637, Protein of unknown function (DUF2637). This family of proteins has no known function.	8.65094e-14
NZ_CP011340.1\|WP_078951226.1\|1893105_1895289_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.19036e-15
NZ_CP011340.1\|WP_053556812.1\|1895424_1899165_-\|S8-family-serine-peptidase	gnl\|CDD\|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	7.11915e-78
NZ_CP011340.1\|WP_005310191.1\|1891225_1892968_-\|pyruvate-dehydrogenase	gnl\|CDD\|180614	PRK06546, PRK06546, pyruvate dehydrogenase; Provisional.	0
NZ_CP011340.1\|WP_005310205.1\|1904868_1905306_+\|alkaline-protease-inhibitor	gnl\|CDD\|366264	pfam00720, SSI, Subtilisin inhibitor-like.	1.32217e-40
NZ_CP011340.1\|WP_005310211.1\|1907645_1908056_-\|cupin-domain-containing-protein	gnl\|CDD\|380361	cd02233, cupin_HNL-like, Granulicella tundricola hydroxynitrile lyase (GtHNL) and related proteins, cupin domain. This family includes archaeal, eukaryotic, and bacterial proteins homologous to hydroxynitrile lyase from Granulicella tundricola (GtHNL), a novel class of HNLs that does not show any sequence or structural similarity to any other HNL and does not contain conserved motifs typical of HNLs. HNLs comprise a diverse group of enzymes that vary in terms of their substrate specificity, enantioselectivity and the need for a co-factor. In plants, they catalyze the reversible cleavage of cyanohydrins, yielding HCN and aldehydes or ketones. Also included in this family is TM1010 from Thermotoga maritima, a protein of unknown function. Some but not all members of this family have N- or C-terminal carboxymuconolactone decarboxylase domains in addition to the cupin domain. Members of this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	2.94723e-42
NZ_CP011340.1\|WP_005310199.1\|1901296_1902415_-\|ribosome-small-subunit-dependent-GTPase-A	gnl\|CDD\|234988	PRK01889, PRK01889, GTPase RsgA; Reviewed.	0
NZ_CP011340.1\|WP_078535475.1\|1902904_1903477_+\|LysE-family-transporter	gnl\|CDD\|280058	pfam01810, LysE, LysE type translocator. This family consists of various hypothetical proteins and an l-lysine exporter LysE from Corynebacterium glutamicum which is proposed to be the first of a novel family of translocators. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine.	3.04026e-08

>NZ_CP011340.1|WP_053556813.1|1900361_1900847_+|DUF456-domain-containing-protein
MGVWQLLMVGGVMLLGLLGVIVPGVPGPWLVWAAVLWWSLHVQTGVAWFLLVGATAVLLINQVIVWLLPNRRLRGLGVTRRMAASAGLGALAGFFLIPVIGAVPGFVGGIYGSERLRLGGHGPAMASTRAVMRAAGTSVLVELMGCLMVVGAWVGAVVSGG
>NZ_CP011340.1|WP_005310195.1|1899351_1900344_+|LuxR-family-transcriptional-regulator
MLGAIGLDERQESAYRALVALGAAEISDLAHRLAMPEPDTERALRRLEQQGLAAQSSARTGRWVAAPPGVALGALLTQQRHELEQAELAAALLAEEYRAESVEPAVHDLVEVVTGASAVVHRFVQLQLGATEEVCALVTGNPIAVSGMDNDAEENATSRGVAYRVVLEREVLTKPDGITELSAALSRDEQVRVVDRVPTKLVIADRSLAMVPLTGRGAEPAALVVHASGLLESLMGLFEAVWREALPLRLGARGIEEELCGPDATDLEILSLLLAGMTDASVAKQLDLGLRTVQRRVKGLMELTGVTTRLQLGWHAYAKGWVARDLHDRL
>NZ_CP011340.1|WP_053556812.1|1895424_1899165_-|S8-family-serine-peptidase
MRPITRTALGAATAAVLTVTAIAPSAAEPQDGASQKRPPAGSEAAARQGDRPVTVTLVTGDRVLVGRDASGAPSATVLPRPDGTTATTQTRRSGQDLYVYPEDAVAALAAGTVDEQLFNVTGLVRQGYDDAHTTALPLIATYGRDVARSAPAVPRGAKRGLVLRAVGGVALKADKKQAADFWADVTNTRSRSASGLKKLWLDRKVEATLDRSTRQVAADLAWAAGYDGKGTKVAVLDTGVDAEHPDLKGRVAAAENFTDSDTPGDSHGHGTHTLSTVGGSGAASDGRNKGVAPGAELLSGKVLNDYGNGAESWIIAGMQWAVDRKADVVSMSLGSPLPTDCTDPMSTAAAELARNEGTLFVVAAGNSGPSHNTVSSPGCVPGVLTVGAVDRDDSTAQFSSRGPAIVSHTLKPEIAAPGVAISAAAAGGRGPYAYRSMSGTSMATPHVAGAAAIVKQRHPDWTAQQIKAALVSSAKSSVPGDVRETGGGRLDVKAAVDTTVTGAPAVQGGTFDWPQHRGDRTTVQVPYTNSGDEPVRLDLAVRKVTGNDGSPVRSEIARLGARSVTVPAGATVEVPLTLDPSARIERAQYGDVTGRVVATGDGVTVSTPFSLYVQPETVGLRVKLVDRQGEPAAGSSSLDVIGTDDATGERRFNDGAADQVYRLRPGSYLLSSFVTSGDGTVSYLGRPEIELTKDTTVVLDAREAHRLGIGTDRRSEVRVGTLGFARNWDDTWLHSGTISGGRAVTGYYADVQGRAKDGDFEFASHWRAYAPLIEELAVEGGPRLRPVAASVGSVNLDGTGTAGLVDAGTGTPAELEAAGVKGKFALVHVPDGGAGAVSAARNAKAAGALAVVVHRDAPGVYLPSTGFGTAPHPVIGIEAAEARLLLERLADGPVSLRWKATAKSPYVYNLSFPEGGPVASDRTYRVRDTKLARNDTTYHAMGVTADYRDVVVAHRPSGIQASVSGVDLVPAPGERAEFYTPGDTRWEHHVSSSFPWGEYLSDPARAYKAGERREESWYGGVLAPAAPLDATGEQALAAERQGNLLGVAPAFWGDSEHVGTAGSFGDIGNTRLVRDGEEIGRTAYPFGAYEVPAGDAAYELTLTTMKVGSPAAVWKRSTRLETTWKFRSKLDENVYSQGIPLLFPGYELPEDGLKTVAAGDGLRIGLSATGHAGYRPGALTGAKLSYSYDGGQTWTAAATERQGDGAWNATVNHAGAAGKAVTLRTELTDARGNSVTQLVIDAYAVR
>NZ_CP011340.1|WP_078951226.1|1893105_1895289_-|hypothetical-protein
MSEQGDRPNRPTTEDDWWSRLYDESAPDTGGPSTSSDSLDDRFDSASGTVTTRPHAWWEHPPPPPTGRAGQRGVRDDGPSSGVPPVPAPPSPATRGPGVGDEPPGAALPPPAPGTRLPGAALPGDATAEGRSAPPGHGGEAAHTGAGATPAGEDPRGPSAAPPAPPPPAQPPTTSPARPDGTERPGSAVSSDRRDGASATAGSAAGGPFSPAGGGGAGAPSGSAGSGRPPSVASGDRRDGASAAAGSADGGPLSPAGGGGAGAPSGSAGSGRPPSVASGDRRDGASAASGSGGGDRADGGPSSPAGEGGAGAPSGAEAPVRPQPTAGTDPREDPTTPPAPAPAPAAAGTPPSREGGARAGVPPRLGPAGGGNPADRPPVAAGDDAPGASAHSARPLVPAQAPRGGVVGDGPPTYDAEPTALPAAEADGLDQLVADTVLDGARYGTYTLRAVSVRGDSARFRGEPRRDALLTARFGTGPAALVLVAVAGGIRGSDTAHLAAADACRWIGRAVGRSHARLAEDIRAGRRGDLKSGLHRLTDRSLGKLRARAAELGVEPEVYTAGLRCLLLSADPACRTRVFFGVGGGGLFRLRDGAWQDLEPSVPDRADVTGAPVVGFGSAVPEATPEGDRLTMDLGIPTGPSPYIETPPPPAAEPFRFRASVARPGDTLLLCSQGLAAPVRGEAALAKELAERWRGPKAPGMAQFLADTQLRVKGYADDRTAVAVWEA
>NZ_CP011340.1|WP_005310191.1|1891225_1892968_-|pyruvate-dehydrogenase
MARKNVAEQFVDILVRAGVQRLYGVVGDSLNPVVDAVRRTPGIDWVQVRHEEAAAFAAGAEAQITGKLAACAGSCGPGNLHLINGLYDAHRSMAPVLALASHIPSSEIGLGYFQETHPDQLFRECSHYSELISSPQQMPRLLQTAIQHAVGRGGVSVVSLPGDIADRPAPEKSIEHALVTTRPTARPGDAEIDKLVRMIDEADRVTLFCGSGTAGAHAEVMQFAERIKSPVGHALRGKEWIQYDNPYDVGMSGLLGYGAAYEATHECDLLLLLGTDFPYNAFLPDDVKIAQVDVRPEHLGRRSKLDLAVWGDVRETLRCITPKVRAKADRRFLDKMLKKHADALEGVVRAYTRKVEKHVPVHPEYVAAVLDELADDDAVFTVDTGMCNVWAARYISPNGRRRIIGSFSHGSMANALPQAIGAQFVDRDRQVVSMSGDGGFTMLMGDFLTLVQYDLPVKIVLFNNSSLSMVELEMLVAGLPSFGTAYRNPDFAAVARAAGAYGVRVEKPKQLAGALKDAFKHKGPALVDVVTDPNALSIPPKISAEMVTGFALSASKIVLDGGVGRMVQMARSNLRNVPRP
>NZ_CP011340.1|WP_005310189.1|1890467_1890905_-|ATP-binding-protein
MTGRHGGAGVRGRLHRRLGNGDLTAVPEVRHALRDLLGKWPERTDDAGAADAADVAELLASELVTNALIHTDHGAVVTATVEDSRLHVEVQDFMAGLPVPDLPNADLGTGGRGLVLVERLADAWGVRTAQGVGKVIWFELHAGAA
>NZ_CP011340.1|WP_037776117.1|1889237_1890308_+|DUF2637-domain-containing-protein
MRLTDISLDWLLPGAVMILGVLAAVAVLARGKRAGDKAAADDSWERSEERRRRKEAVYGTASYVLLFCCAAVAAALSFHGLVGFGRQNLNLTGGWEYLVPFGLDGAAMFCSVLAVREASHGDAALGSRLLVWTFAGAAAWFNWVHAPRGLDHAGAPQFFAGMSLSAAVLFDRALKQTRRAALREQGLVPRPLPQIRIVRWLRAPRETFAAWSLMLLEGVRTLDEAVDEVREDRRQKQQNRMRRRDREKLERAQIRALNRQHRSWGLSRADRGTQLPALGPATGGAQQPGSSSSSVVEPVIAEPGQLPVRTRPSLQALKPAGPEPVTVDLTAEDDTQALPRLDSLERKLKDLEQQFG
>NZ_CP011340.1|WP_037773424.1|1888196_1889042_+|(2Fe-2S)-binding-protein
MTVPALMPGLTSPVTDAYERLAEVFPGLRVKELTDEGPTPDGAGWVRAADLAAGGAPLDAFLAWDNAQVLRDYGQQARPDVVASFGLHRYAWPACLLITVPWFLVRRVPRVPVEGVSFQRALGHMTVRVREFACLPDDPAAQLPGARVVPDEEALRGEVRAAVAEHIGPVLDGFGARMRRGKRALWGMATDEIVEGLWYVAHLLGEEQRAVAELEQLLPGTTKPYVGTAGFRELTGPNGERLPTRDRASCCLFYTLRPEDTCVTCPRTCDADRVARLQQTA
>NZ_CP011340.1|WP_037773422.1|1887284_1888046_-|GntR-family-transcriptional-regulator
MEQARARDLAVPQPYASVHVPAQGGPGAAREQVRGEHTHSEPPALRPVQRHSVRGQILDALRTALVDGDLVPGEVYSAPVLGERYGVSATPVREAMQQLVMEGAVEVVPNRGFRVARRTARELAELAEVRALIEVPVLLRLARTVPADRWNALRPLAEATAAAAATGDRASYAETDRAFHRAVLALAGNEQLLTVADDLHRRSQWPLSGAPTTRRADLVADAAEHTALLDALAAQDLTVVQALVREHFAGSDV
>NZ_CP011340.1|WP_053556811.1|1886063_1887254_-|hypothetical-protein
MRGTVWAVANQLGVVAGTPAELLSALLAGPPRTVRLGGAGHDPDEVAELADVLREFGHVRVVVEAPDEDAPVSKPGDDGPVDVADAEAVCAADPVRVTAAYEAADDEHGGLRSAWLRAGQSLIRDQDPARRALVLRTALPPDADPRIRQALARSAAAAPWHMEWAGACPIAALTVLPGGAPVVADPGGGVRVLPDGGREQSTATRVRAAAASGEDTVLLLDERGRLHRHGGTGTALTKAVAATLARHPGTALAAAADVVLVGDRMGSVHAFGSDGLHQAALHSGRVTALAATASPSLTVRTGGTDGAVRVWSPADGGHGSTVSQRSSPVVALHMGPTPQGPALAAAWADGLVELHRPGRRDVLGFRPGPAVRAVAVTPDGALWVGTEETLIRLRPR
>NZ_CP011340.1|WP_005310199.1|1901296_1902415_-|ribosome-small-subunit-dependent-GTPase-A
MSNTQPHTSSLTSAAQDTLAPYGWDTAWEAEFAPYAAQGLLPGRVVRVDRGQCDLVTPRGVMRGDTEFVTPRDPMRVVCTGDWVAVDPDGDPQFVRTLLPRRTAIVRSTSSKRSEGQVLATNIDHIVICVSLAVELDLGRIERFLALAWESGAQPLVALTKADLVPDVTGLSYLVQDVETTAPGVQVIPVSSATGEGVEVLTAIVSGGTSVLLGVSGAGKSTLANALLGEDVMDVQATRDVDGKGRHTTTTRNLLVMPGGGVLIDTPGLRGVGLWDAEAGVHQVFSEIEDLAAQCRFHDCAHEAEPGCAVLGAIEDGTLPERRLDSYRKLIRENQRIVAKTDARLRAEIRRDWKLKGAQGRAAMEAKRGRVR
>NZ_CP011340.1|WP_078535475.1|1902904_1903477_+|LysE-family-transporter
MPVGAVTVMIVTLSAQTSLRTGLAGAMGTATADGLYALIAALTGAALAGLLRPVAGPMRWTAAVVLLALAAKGLADAVRRSLDPGSVRQVEEKRPFSVYLQFLGLTVLNPLTIVYFSALVLALRNDDWPPMGGLMFVVAAFAASASWQALLAVGGALVGRALTSDKGRLGTALVGNGVIIFLAARLLLGG
>NZ_CP011340.1|WP_005310203.1|1903489_1904536_-|PHP-domain-containing-protein
MEPVEALNRVAFLLERSLAETYRVRAFRTAAAALAELDAQEIADRAEAGTLVKLKGIGPKTARVIEEALAGGTPAYLERLEEEAGGPLADGGSALRAALRGDCHLHSDWSDGGSPIDEMGRAAAALGHEWAVLTDHSPTLTVAGGLTAERLRAQLDVVAELNKEWAPFRLLTGIECDILPDGSLDQEPELLDRLDLVVASVHSKLRMDSAAMTRRMVWAVENPLTDVLGHCTGRLVTGGRGTRPESQFDADEVFGACAEHGTALEINSRPERRDPPRRLLRRAVEAGVLFAVDTDAHAPGQLDWQIIGCARAEECGVPAERVVNTWTADEVLEWTRTGRPPAAGGAGR
>NZ_CP011340.1|WP_005310205.1|1904868_1905306_+|alkaline-protease-inhibitor
MRYIARGLALAATTTLALVAAPAVGSAHTAQPGPERLYPPSALVLTVTTGDDATAGTVLRAVTLSCTPTATGTHPAAKAACAELRAAEGAFDAITTRDPSVVCTKQWDPVTVTVDGVWNGTRVEYAHTFGNSCIRSSGSGVLFDF
>NZ_CP011340.1|WP_037773429.1|1905358_1906144_-|hypothetical-protein
MRIPRILTAGALTAAALFGPAAAALAADPSPGVEGDDRAPTEAGTSFRTATPVEQDQKATANASSGDYLYWVFPADAEQRPTVRARVTLPESAERHGASTWRIDVYDGLRRRQACMYGMQARTAAVEASSVELSCTLRTVRSLAEPWSDDPLPGSYYVRLTVTALPEEDLGLPVAAEVEAVSKDAGGAYAVDGALAEPLVPGVSADERRNEEQAALDWSSGRWSDRWIWTGAGGLLAALAGIGGYVLTRGSGRPSRMPPGV
>NZ_CP011340.1|WP_005310209.1|1906143_1907418_-|VWA-domain-containing-protein
MIIRRRPAARICVLLAVLVAGLFPTGIAAADEPVAKESPKVELVLDVSGSMRARDIDGKSRMAAAKQAFNEVLDAVPEEVRLGIRTLGADYPGDDRKRGCKDTRQLYPVGPLDRTEAKAAVATLAPTGWTPIGPALLGAAEDLEGGDATRRIVLITDGEDTCAPLDPCEVAREIAAKGIHLVIDTLGLVPDAKTRTQLRCIAEATGGTYTSVQHTDELSDRVSQLVDRAADPVVTPVATRGAGQCADAPRLEPGLYTDREKFGEHRWYRVDVLPGQELRASVSVGADRAVNKDYGVLLRAVTVHGREIVRGSEAGDGRTDLISTGLRYPKAELEDADGVKPAAETVCLQVSNSFSAPPAVKTEPGLPVELTVDVVDAPGTAFDVAAFGLGRGWWLLGVLVVAGFVAGLLWGWVSRWRIAVWRTN
>NZ_CP011340.1|WP_005310211.1|1907645_1908056_-|cupin-domain-containing-protein
MQITRSPGDTLKGPADWFTGDVCIDAVAAAPSPSRVSAALVRFMPGARTHWHRHPLSQTVFVTEGVGLCRRRGGPIEVIRPGDRVLFEADEEHRHGAAPNRLMVHPAINEADADHDVVHWLTPVTDEEYAAAPTVD
>NZ_CP011340.1|WP_037773430.1|1909039_1909729_-|recombinase-family-protein
MQPPQDDDTADLLAPVPAARTGDLVGYARVSTKGQLLDRQIHALTDAGCIRIFADKKSGKNAEREELRKALDFLREGDTLVVPSLDRLGRSIQDLIAIVSGLRKRGIGFTSLHEALDTTTPGGRLVFHVFAALAEFIRELIVQGTNEGLDAARARGARLGRPPAMTEEQVRHARDLLARPGNTVTSIAKLLGVSRNTIYNYVPELKGGRLALAEATSTPELPQPTRSED
>NZ_CP011340.1|WP_158685145.1|1909905_1910214_-|hypothetical-protein
MTWLVPASFTAGVQADPGPAIWKLVVFLVVGLGLMVPLGVILTILSLELTDIDAGSSALGFYAAFALTLIGGPIGFLAGFTVPWLTGSPGPARWFANLVGLL
>NZ_CP011340.1|WP_005310217.1|1910414_1910897_-|hypothetical-protein
MLSEAMTALAAAGGTAVVQAASTDAWMGFRQQVARWFGRGNPQRESAELERLDQTAAALETADAEQAERARIRQEASWETWFTALLESLDDSQRETAAEELRALLAEHVQAAGGTSAETGGLAAGRDIININATDNSIAAGTISGGASIGRPQVPDPSQG

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Crispr_ID: NZ_CP011340_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_6

2012263-2012345

Orphan

Consensus_repeat	Method
GGCTCCGGCGACGACTGCGTCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_6

>merge|NZ_CP011340|6|2012263-2012345|CRISPRCasFinder
GGCTCCGGCGACGACTGCGTCGAAGTCGCTTTGTCCTGGCACAAGTCCAGCTACAGCAGTGGCTCGGGCGACGACTGCGTCGA

>NZ_CP011340|6|5|2012263-2012345|CRISPRCasFinder
GGCTCCGGCGACGACTGCGTCGA	AGTCGCTTTGTCCTGGCACAAGTCCAGCTACAGCAGT
GGCTCGGGCGACGACTGCGTCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_050791445.1\|2018625_2020908_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005310387.1\|2007537_2009349_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226382
NZ_CP011340.1\|WP_037773470.1\|2014673_2015795_+\|NADAR-family-protein	unknown	unknown	gnl\|CDD\|271319
NZ_CP011340.1\|WP_005310375.1\|2003639_2004239_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_050791444.1\|2010755_2011208_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP011340.1\|WP_005310415.1\|2021654_2022494_-\|ABC-transporter-permease	unknown	unknown	unknown
NZ_CP011340.1\|WP_005310413.1\|2020910_2021588_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_050791443.1\|2005472_2006018_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319835
NZ_CP011340.1\|WP_005310399.1\|2013115_2014468_-\|triacylglycerol-lipase	unknown	unknown	gnl\|CDD\|367570
NZ_CP011340.1\|WP_037776146.1\|2012498_2013011_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005310393.1\|2011372_2012218_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP011340.1\|WP_037776145.1\|2007037_2007436_-\|ASCH-domain-containing-protein	unknown	unknown	gnl\|CDD\|119345
NZ_CP011340.1\|WP_005310389.1\|2009345_2010407_-\|AAA-domain-containing-protein	unknown	unknown	gnl\|CDD\|223786
NZ_CP011340.1\|WP_037773466.1\|2002244_2003429_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP011340.1\|WP_005310404.1\|2015914_2017141_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373067
NZ_CP011340.1\|WP_037773468.1\|2004263_2004698_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319941
NZ_CP011340.1\|WP_005310408.1\|2018137_2018581_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005310417.1\|2022490_2023399_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP011340.1\|WP_005310383.1\|2006385_2006934_+\|DUF1062-domain-containing-protein	unknown	unknown	gnl\|CDD\|368855
NZ_CP011340.1\|WP_005310406.1\|2017301_2017874_+\|deaminase-reductase	unknown	unknown	gnl\|CDD\|334719

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_005310387.1\|2007537_2009349_-\|hypothetical-protein	gnl\|CDD\|226382	COG3864, COG3864, Uncharacterized protein conserved in bacteria [Function unknown].	4.41507e-15
NZ_CP011340.1\|WP_037773470.1\|2014673_2015795_+\|NADAR-family-protein	gnl\|CDD\|271319	cd15457, NADAR, Escherichia coli swarming motility protein YbiA and related proteins. This family of uncharacterized domains was initially classified as Domain of Unknown Function (DUF1768). It contains members such as the E. coli swarming motility protein YbiA. Mutations in YbiA cause defects in Escherichia coli swarming, but not necessarily in motility. More recently, this family has been predicted to be involved in NAD-utilizing pathways, likely to act on ADP-ribose derivatives, and has been named the NADAR (NAD and ADP-ribose) superfamily.	8.59093e-34
NZ_CP011340.1\|WP_050791444.1\|2010755_2011208_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	1.00203e-20
NZ_CP011340.1\|WP_050791443.1\|2005472_2006018_+\|hypothetical-protein	gnl\|CDD\|319835	cd07533, HAD_like, uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily, similar to Parvibaculum lavamentivorans HAD-superfamily hydrolase, subfamily IA, variant 1. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	8.61011e-05
NZ_CP011340.1\|WP_037773466.1\|2002244_2003429_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.99059e-32
NZ_CP011340.1\|WP_005310399.1\|2013115_2014468_-\|triacylglycerol-lipase	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	7.84868e-36
NZ_CP011340.1\|WP_037776145.1\|2007037_2007436_-\|ASCH-domain-containing-protein	gnl\|CDD\|119345	cd06553, ASCH_Ef3133_like, ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation.	1.0468e-28
NZ_CP011340.1\|WP_005310404.1\|2015914_2017141_+\|hypothetical-protein	gnl\|CDD\|373067	pfam14435, SUKH-4, SUKH-4 immunity protein. This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems.	1.07465e-28
NZ_CP011340.1\|WP_005310389.1\|2009345_2010407_-\|AAA-domain-containing-protein	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	8.10308e-17
NZ_CP011340.1\|WP_005310393.1\|2011372_2012218_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.82245e-06
NZ_CP011340.1\|WP_037773468.1\|2004263_2004698_-\|VOC-family-protein	gnl\|CDD\|319941	cd08353, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.1361e-79
NZ_CP011340.1\|WP_005310417.1\|2022490_2023399_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	2.89233e-88
NZ_CP011340.1\|WP_005310383.1\|2006385_2006934_+\|DUF1062-domain-containing-protein	gnl\|CDD\|368855	pfam06353, DUF1062, Protein of unknown function (DUF1062). This family consists of several hypothetical bacterial proteins of unknown function.	9.15794e-57
NZ_CP011340.1\|WP_005310406.1\|2017301_2017874_+\|deaminase-reductase	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	2.04397e-18

>NZ_CP011340.1|WP_005310393.1|2011372_2012218_+|helix-turn-helix-domain-containing-protein
MTETETAGTSGGGEPEVSESLKSFGEVVKAFRKRARLTQEEFAPLVRYSLPTVASIEQGRRFPPVDFVDRAEEVLDAFGTLKGAARHLSRKPGLASWFRQWAQLEAEAVSLYTYECRLIPGLLQTEAYAQRLFRDQLPPLGDEQIEAQMAARKERQRLLTERPNTAYSFIVEEHLLRRQLDGERTTRELVDHLIRLAERRNIELQIMPVVRDSHAGLDGPMRLLETSDNHWLAYCEGQESGRLIHDRKVVSMLQMRYARMRSQALTLPDSLGLLRQMRGAA
>NZ_CP011340.1|WP_050791444.1|2010755_2011208_-|ATP-binding-protein
MQPPVTPQQLGTVRVFTQRFSSTPLGARLARHLALHQLHAWGIRHGTDVSDTVALLVAELAANAVTHGRVPGRDFELRLTRTPPTLRIEVSDTRGERRPPSRAAVPAPLAESGRGLLLVEALADRWVVLDRVPVGKTVRAELDLGGAVAP
>NZ_CP011340.1|WP_005310389.1|2009345_2010407_-|AAA-domain-containing-protein
MQAAVTVTPAQIPELLLGLATVRPVFLWGAPGIGKSSLVRRFADSLGLECVSLLGTQLAPEDLIGVPQIRDGRSVFCPPEAIARDEPYCLFLDELNAASPDVQKAFYSLILDRRIGSYELPAGSIVIGAGNRATDNALARPIASALVNRLTHVHLQASAEDWLVWAGEHGIHPWVTDYLTDRPDHLWSQPPKTEEPFSTPRSWHMLSDALHSFGPAIDENTLKVVVHGTLTPAHAVSFCGYAKIVRHTFGIEAILKGDASWPSRLEDRDLLYYLAEAFRGRLVKELPRQKEHVSPSLRQTVYRSKSLLVQLAEISVEVAQTVIADDVDGQPVLPAWFLVEAARDMPRLVEARR
>NZ_CP011340.1|WP_005310387.1|2007537_2009349_-|hypothetical-protein
MKTAARKKGDKPDPAAEAFAAGLAMVKRNPAFAAVEADFCRQGKCAATPAGGLAAVDSNGVVHVHPTKRASPEEWAWTLAHCLLHLGFGHVPAADERLREQPDRFDLAARCTVVNRFLLTFPVGSPPGHAPGTYQGGDEELLAARWRRDGIPAAYRHCGTAGEHPDQVLTTWRAWGSSAVPDWETAFARALTRSVSAAMDVAGGRRDRVTGERLPQRPWDRALNWFVSSYPLLGGIAAGLTVVADAELARAQDISVAAVSSTAGEIYVNPLRTFTDEQWQFILAHEMLHAALRHGERRGMRDPLLFNVAADFVVNGWLVEMRVGEMPEGLLHDPELKDLSVEEVYDRIATDLRRRRRLATLRGKGMGDILGDPLPHAASRPYADLDDFYRRGLVQGFDLHQYGERGLLPAGLVQEIRALAHPPVPWDARLARWFDEYVPRPEPVRSYARPARRQASTPDIPRAGRYFPQEEVPRCTFGVVLDTSGSMNSALLGKALGAIASYAEARDVPAARVVFCDAAAYDAGYVPPVEIAGRVRVRGRGGTVLQPGIDLLHRAGDFPANAPALVITDGWRDTLRIRREHAFLIPQGASLPFTPRGPVFRLT
>NZ_CP011340.1|WP_037776145.1|2007037_2007436_-|ASCH-domain-containing-protein
MWPRIDGLRTLDLGVPGELRGTRNALVLTGRKRATAGLLEADRTEGEEPETVGERLVLVGSDGQRVTEVVVESVDITPLGSVPWDFARAEGEGDADLAEWRAGHIAYWQSVGRTVDDRTDIVCVRFALAPPT
>NZ_CP011340.1|WP_005310383.1|2006385_2006934_+|DUF1062-domain-containing-protein
MLNNWVVVPTCLPLVLRHCHACASRRFRASGKFRVNANHKLIDAWLLVLCTTCGDTAKLSVLERMNVRSVRPELLDRLHDNDLGLTAELLQDPVVRRRNRIALDWDGAWRLDTGGSDHLGREVIDISVRFAARIPVRPVRLIAEGCGLSRAEVERLITEGKLVSAVRLSGKLSGDFTFTLKR
>NZ_CP011340.1|WP_050791443.1|2005472_2006018_+|hypothetical-protein
MGSCLAVAVLLLPLGGYGLARMGVAPEGTPIVLGLLSAIAGFVVLPSLCEERVPFRHSSSRLTAHTLTGERSVDLDRITTVRLLTTFSYGSAYRTLLVRDAHGVRLGITTERSRRKLRRAIEKADANDARGAPGPRVSRAARAHLGLPPRRGLVVHTVLAFLLLTVSSSLYVVAVLRLGGQ
>NZ_CP011340.1|WP_037773468.1|2004263_2004698_-|VOC-family-protein
MDNVGIVVDDLEAAVAFFTELGMELEGEAQIEGTVADRMLGLDGVRSAIAMMRTPDGHGKLELTKFHAPAAVTAGPLNPPPNTLGLHRVMFAVDDIDDTIVRLRRHGAELLGEVAQYENVYRLCNLRGPSGIIVALAERIGRAH
>NZ_CP011340.1|WP_005310375.1|2003639_2004239_+|hypothetical-protein
MTQTTVTSTTSATAATTSSGLRSLHLIRVAFSLIWVALVFTTSATLVSADEPTMIAAVLLVVYPLWDAVATLIERRLAGTGSTNGVSTVNIGLGLATTAGMIVAVFSTIGTALLVFGVWALLSGAIQLVVAIRRRRTVGAQWPMAVSGGQSVLAGAVIAATSASAASNLSTVAGYSAFGAFWFLVSVVALSIRGRRGKR
>NZ_CP011340.1|WP_037773466.1|2002244_2003429_-|two-component-sensor-histidine-kinase
MVKAQNSQDGPAAPLWVRRPEVLHRVAYAVAALVFTGQIVAAAVRGADWPTALSVLLAGGGVALSWWRPWAGLVVTSAASFAVTAVGDDPLSVWMMAVLVLFSVTLRGKQPLAGTGIVAAFFLGAFMTVGGFRGGAVVGAAALFSAMAGGATGAALRIHREHWWTLDERAEIAIATREIEATRRVTEERLRIARDLHDVIGHQVAMLSLHLGAAEIGLPEDAESSRQALVSARSSARTVVVETQRILALLRLGDDVSGDEALRPTPALSGLDGLIASFESIGLDVRRSIDIPAGFVEPSVGVTVYRVVQEALTNAYRHGEGTATVDVREHDGTIRVTVENRVGHSPRGSDPGSGLGLVGMRERVESSNGRLTIDSHDGRFRVHAEFSPLGAVLR
>NZ_CP011340.1|WP_037776146.1|2012498_2013011_+|hypothetical-protein
MLPAGVRDQVDGYVLQDAYLQAVRVAFEAGRARGLGLAEAQLVVNARYIHHGDTIARTPDDPLDVESLAARAAGAPGRVVAIEAVWDGDTVHDWFVELLAVTTEPDADHPLATVYRSTAERYLGDRSPGPLDPSAAAADRAGRALAAHLSLPFHFASPAVPDDEAPRWRG
>NZ_CP011340.1|WP_005310399.1|2013115_2014468_-|triacylglycerol-lipase
MNRRAAGLLATAVVAALTVGTAPAATAAPTTATAYAQTNTVTSDPFYRYDGSKPLSSYKPGDVLKKRTLDYHVIGIPTPVKAIQLLYRSTDAQGRPSANVTTVVRSHVGDGSKAVSYQSFYDSLDPEHGPSRAIAGDVSLGGMIANVEAVVMAPMLLKGYDLVIPDTEGQTAEFAAGPAYGTNTLDSIRASIRAEGSRLHGGTEFGLFGYSGGAIATNWAVALAPVYAPEVNEQLVGFAEGGVLVAPAHNLKYVDGSLAWNGVIPMAVIGVARAYDIDLEPYLSEKGREVFDELEYASIADALGRYPGMTWKELVKPGYENPNAIPAFTEAVNKVNLGQAATPTVPGFIGQGNAGRLEGTFGNPPGIGTGDGVMVAGDVRALARQYCATGNEAITYEQYNLLSHVGAMLYWTPRAMNWLDDRFDGETAPSSCGRIPAGNSLEPERPAVAD
>NZ_CP011340.1|WP_037773470.1|2014673_2015795_+|NADAR-family-protein
MIGNRTTHRTADGVRIPGTWRHAFIRNGGQYFLTDLFIFADGIVDCWGFVTLDEFEKKLRSGWVATSFPEGADVSAHGLASWKFAEPHTWLTPELLLAEVRETVEQLNGRPDSTARCLAAVDVFLADRTEENRAAARAAYLAIPETRRHYALGDMDSKDWPLQALVAGPDGELEEWSDEPVSQEDYDEAITYFEERARSIAERSPRTPADGSATSFAPAVHLYESYVRQPTDDPGTAALRNDYPAPVDIDGVTYPSVAHAYWALSVTGEDTRAAVLATGNANMARRIAAEAARRPGWEHARTAVMTSLLRAKYTQHPDLAEILLATADATVVYDDSDSAFWGNDTGQGRNWTGRLLELVRSELQARRAGILPA
>NZ_CP011340.1|WP_005310404.1|2015914_2017141_+|hypothetical-protein
MSANTVTVPMDMLHPAITHEATRRWLTTAGLPVEGPIRFRPATGAGMRTLRQYVADEGGDSAQLDRHIAELLLIGHLCGDEGCDGDEVVLDGSTGRVFSMWLYTKSPEGAKLFPLAPSLDALVRFVSAVCEFASLRGAFAALAGRTGAEAVAEASALLMSVFTDEEWGESGWGSAGDPAGWEYAVPAFWRMIAVIRPMALIAGPGQGLRLELPKGLLDEEFGADGIVRVAPSEIPAALTHEPTRRFLTDVGLPRDAQMFCMDPEDLLVPLPDDRERSKQNPAHQHLWNGSDTLPPDAEHLLVLGGLMHDFTVLLDGRTGEVHYAEYDADRVVPVNADVSTLAFTVWLHNRERQIDEEHDFTDDFYYPLAVTMTDTLAAVDPVACLPARGPDDFRYWPEVFHDCAGGVL
>NZ_CP011340.1|WP_005310406.1|2017301_2017874_+|deaminase-reductase
MAKIVVSENVSLDGVVQDPTGEEGFRHGGWFGRLGDRDRAEWAEVEAAEAMGTDALLLGRRSYEWFAARWPSRSGAWADRLNSLPKYVVSSTLEDPAWNNTTVLEGEVVSGVSKLKQELDGDIVVYASSRLVRTLMDHDLVDEVRLMVHPVVLGAGDRLFGGTGDMKRLRLLGTRTVGDGLAHLTYEVVR
>NZ_CP011340.1|WP_005310408.1|2018137_2018581_+|hypothetical-protein
MAWDEWEQVKAASAASGSATRLNQLAASGSGSGSDLTVHDNVLGKLGDMARSLHGQLATDGDHARVATFEASNDLFNGGLDMGAGLLEVHDAWNTKLRTLREACGHISNHLDHSRSTHAAEEKKIVLGMQDADGRTMTVSRIYDQFT
>NZ_CP011340.1|WP_050791445.1|2018625_2020908_+|hypothetical-protein
MVTCQELQDLNFGKLNTAVTQWKQMLDKLVLLADGGDGGVNAADFERKAAAADWKGDNATVTKEFTTTTARQFDDMVTEARSIHKILQEAATNLKKNQDDLKAAIDKWAKQWIHIDGKGTAMYSGPPREVPGGPKEQPSQEVVDSAAAEIAKILDEANETDRIAARALRKHAESKYDFDETGYSGLKDADRRQGIEDADAMVELAGKGDQLTDAELKRFNEIAKYHRDNPAFAERFATRLGADGTLEFWRSIADPGQGRTPEPGSDRAKILAKVQDNLGITLANASRSDSPEMQQWKDRMIELGDDHIKSSSGIPSAPYGFKVLGPLMTEGKWDTDFLNKYGTRLLEFERKSDDPVLGGPSQLWNSHFDPAQLSYPPGATKPESDPVADLMEALGHNPEASLEFFDGSSGKGDDAMSNWDYLVEKGGEGAREWPTDEDGKTTGYKNLGHALEAGTLGYAYDDKTPSIPPLDSPEAIAAREERTLLMDRVVDHYTSADVIDKQDGIRDSLANMAAGHIDSLNYSMADWGGTGAASGRDGLYNSEEQRLRDFGETGSKNFLRALASDEGSYETVATAQQVYGTSSMAVQGNQSDALDAGVNSARMHGLLDQARAEAIGKEFADDKDQRNLELEKQGEWRKFAAEAAVGVGVGAATALIVPTGPLAMVAVPLAIETVGGAINTQVSTDTMQWLKDHEFDNFDDSVAGIDKAKYDGSRNAMTPLLNYAEAQGMSEDDIRRLAERAEGRYNDGGRLGGTEAARGW
>NZ_CP011340.1|WP_005310413.1|2020910_2021588_+|hypothetical-protein
MRRQLTPAALALVLLGAVACTAGEGGEEDPPPATADASACDAVLGDAGVAWLKDRTGGAARPEAGDDLDKARSLFHRQVKAWGPDDSGARTFLRADLCRATGGAGRFEVRYGPSYFPFDEPFDKASDVSPAQTVTEVNSDVRLVHGKDADGATRYRVYVRCKIAGTPAQQESEVPIEGLMTDTLTGDTDARVHLTRLLHSAKVVADAFDCVNEPVVPEEPPASPA
>NZ_CP011340.1|WP_005310415.1|2021654_2022494_-|ABC-transporter-permease
MTTALAHPTAQLRARFLDLAAAEWLKLWSLRSTGWSLLVAALAVLAFNVGKAWDNVRYWPDGEPGYAERFIADGIPLMHAFTGNAGTVMMLAAGAFGALAVTGEYSTGLVATTFAAVPARRSVMTAKVCVVATVMTVFGVLVAVTSFASTQAILATEGAGVSIDRPGAVRVIVASALLAPVSALVGTALGTLLRHGAGAVVGSVVILMLLPVVLDDGRHWSAVLAHAMPYEAWLRLVDVPYGGPGILHPWSAGGAWTVYAVWALASTAVAVTAVHRRDQ
>NZ_CP011340.1|WP_005310417.1|2022490_2023399_-|ATP-binding-cassette-domain-containing-protein
MIEVNELTKRYGGTTAVKNLTFTVRPGRVTGFLGPNGSGKSTTLRMVLGLHAPTSGTATVDGRPFRSRPRGLRHVGALLDAGHVHGGRSAAAHLAALARSNRIPRSRVDQVLEQVGLAGAARRRIGGYSLGMRQRLGIAVALLGDPPVLLFDEPLNGLDPEGVKWVRGLFRQLAAEGRTVFVSSHLMSEMEHTADELIVIGRGELIAAESLTDFAARGSGAAVAVRTPHGDRLAALLTAEGATVRADGDLLTVTGTSAERVGELALDHRILLHEITTRGASLEDAFMELTAGSVEYVAGETR

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Crispr_ID: NZ_CP011340_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_7

2284237-2284350

Orphan

Consensus_repeat	Method
CCGTTCCCGCGTCCGCCGTTCTCG	CRISPRCasFinder

2 spacers

csa3

The CRISPR arrays of NZ_CP011340_7

>merge|NZ_CP011340|7|2284237-2284350|CRISPRCasFinder
CCGTGCTCGCGACACCGGTTTTCGACAGGGCCGTTCCCGCGTCCGCCGTTCTCGAGCTCCCCGTTCTCGCGTCCGCCGTACTCGAGTTCCCCGTTCTCGCGTCCGCCGTTCTCG

>NZ_CP011340|7|6|2284237-2284350|CRISPRCasFinder
CCGTGCTCGCGACACCGGTTTTCG	ACAGGGCCGTTCCCGCGTCCG
CCGTTCTCGAGCTCCCCGTTCTCG	CGTCCGCCGTACTCGAGTTCC
CCGTTCTCGCGTCCGCCGTTCTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_005310777.1\|2285089_2286682_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP011340.1\|WP_037773553.1\|2269466_2272124_-\|xyloglucanase	unknown	unknown	gnl\|CDD\|366161
NZ_CP011340.1\|WP_005310775.1\|2284449_2284923_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP011340.1\|WP_037776201.1\|2286733_2287369_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|181904
NZ_CP011340.1\|WP_050791461.1\|2290282_2291089_-\|LamB/YcsF-family-protein	unknown	unknown	gnl\|CDD\|377121
NZ_CP011340.1\|WP_078535230.1\|2279370_2279577_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005310783.1\|2288475_2288661_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP011340.1\|WP_005310765.1\|2275667_2276468_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP011340.1\|WP_037773554.1\|2274505_2275507_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197713
NZ_CP011340.1\|WP_005310761.1\|2272851_2274330_-\|glutamate--cysteine-ligase	unknown	unknown	gnl\|CDD\|237408
NZ_CP011340.1\|WP_005310792.1\|2292369_2293164_+\|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|176902
NZ_CP011340.1\|WP_005310753.1\|2267998_2268877_-\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|381605
NZ_CP011340.1\|WP_005310773.1\|2281786_2283880_-\|elongation-factor-G	unknown	unknown	gnl\|CDD\|237358
NZ_CP011340.1\|WP_005310771.1\|2280713_2281307_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226851
NZ_CP011340.1\|WP_053557717.1\|2287657_2288479_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP011340.1\|WP_005310769.1\|2278952_2279387_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_053556854.1\|2289605_2290286_-\|allophanate-hydrolase-subunit-1	unknown	unknown	gnl\|CDD\|367142
NZ_CP011340.1\|WP_005310751.1\|2267024_2267282_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_053556853.1\|2288736_2289609_-\|biotin-dependent-carboxyltransferase-family-protein	unknown	unknown	gnl\|CDD\|376868
NZ_CP011340.1\|WP_005310790.1\|2291280_2291976_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_005310777.1\|2285089_2286682_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.16459e-76
NZ_CP011340.1\|WP_037773553.1\|2269466_2272124_-\|xyloglucanase	gnl\|CDD\|366161	pfam00553, CBM_2, Cellulose binding domain. Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.	2.08854e-29
NZ_CP011340.1\|WP_005310775.1\|2284449_2284923_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	8.07796e-12
NZ_CP011340.1\|WP_037776201.1\|2286733_2287369_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|181904	PRK09491, rimI, ribosomal-protein-alanine N-acetyltransferase; Provisional.	4.03685e-11
NZ_CP011340.1\|WP_050791461.1\|2290282_2291089_-\|LamB/YcsF-family-protein	gnl\|CDD\|377121	pfam03746, LamB_YcsF, LamB/YcsF family. This family includes LamB. The lam locus of Aspergillus nidulans consists of two divergently transcribed genes, lamA and lamB, involved in the utilisation of lactams such as 2-pyrrolidinone. Both genes are under the control of the positive regulatory gene amdR and are subject to carbon and nitrogen metabolite repression. The exact molecular function of the proteins in this family is unknown.	2.08291e-131
NZ_CP011340.1\|WP_005310783.1\|2288475_2288661_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	3.98282e-18
NZ_CP011340.1\|WP_005310765.1\|2275667_2276468_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.941e-26
NZ_CP011340.1\|WP_037773554.1\|2274505_2275507_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	3.36998e-09
NZ_CP011340.1\|WP_005310761.1\|2272851_2274330_-\|glutamate--cysteine-ligase	gnl\|CDD\|237408	PRK13517, PRK13517, glutamate--cysteine ligase.	3.68077e-05
NZ_CP011340.1\|WP_005310792.1\|2292369_2293164_+\|metalloregulator-ArsR/SmtB-family-transcription-factor	gnl\|CDD\|176902	cd08893, SRPBCC_CalC_Aha1-like_GntR-HTH, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. Some proteins in this subgroup contain an N-terminal winged helix-turn-helix DNA-binding domain found in the GntR family of proteins which include bacterial transcriptional regulators and their putative homologs from eukaryota and archaea.	4.9664e-59
NZ_CP011340.1\|WP_005310753.1\|2267998_2268877_-\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|381605	cd13402, LT_TF-like, lytic transglycosylase-like domain of tail fiber-like proteins and similar domains. These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	2.36684e-29
NZ_CP011340.1\|WP_005310773.1\|2281786_2283880_-\|elongation-factor-G	gnl\|CDD\|237358	PRK13351, PRK13351, elongation factor G-like protein.	0
NZ_CP011340.1\|WP_005310771.1\|2280713_2281307_+\|hypothetical-protein	gnl\|CDD\|226851	COG4430, COG4430, Uncharacterized protein conserved in bacteria [Function unknown].	4.42931e-48
NZ_CP011340.1\|WP_053557717.1\|2287657_2288479_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.17618e-07
NZ_CP011340.1\|WP_053556853.1\|2288736_2289609_-\|biotin-dependent-carboxyltransferase-family-protein	gnl\|CDD\|376868	pfam02626, CT_A_B, Carboxyltransferase domain, subdomain A and B. Urea carboxylase (UC) catalyzes a two-step, ATP- and biotin-dependent carboxylation reaction of urea. It is composed of biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier protein (BCCP) domains. The CT domain of UC consists of four subdomains, named A, B, C and D. This domain covers the A and B subdomains of the CT domain. This domain covers the whole length of KipA (kinase A) from Bacillus subtilis. It can also be found in S. cerevisiae urea amidolyase Dur1,2, which is a multifunctional biotin-dependent enzyme with domains for urea carboxylase and allophanate (urea carboxylate) hydrolase activity.	1.2311e-109
NZ_CP011340.1\|WP_053556854.1\|2289605_2290286_-\|allophanate-hydrolase-subunit-1	gnl\|CDD\|367142	pfam02682, CT_C_D, Carboxyltransferase domain, subdomain C and D. Urea carboxylase (UC) catalyzes a two-step, ATP- and biotin-dependent carboxylation reaction of urea. It is composed of biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier protein (BCCP) domains. The CT domain of UC consists of four subdomains, named A, B, C and D. This domain covers the C and D subdomains of the CT domain. This domain covers the whole length of kipI (kinase A inhibitor) from Bacillus subtilis. It can also be found in S. cerevisiae urea amidolyase Dur1,2, which is a multifunctional biotin-dependent enzyme with domains for urea carboxylase and allophanate (urea carboxylate) hydrolase activity.	5.86976e-70
NZ_CP011340.1\|WP_005310790.1\|2291280_2291976_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	7.44421e-35

>NZ_CP011340.1|WP_005310773.1|2281786_2283880_-|elongation-factor-G
MRTDPRHRSASTSPLTRVRNLGILAHVDAGKTTVTERILYLTGATHKRGEVHDGTTVTDFDPQERDRGITIFAAAVSCDWDGHRINLIDTPGHVDFADEVERSLRVLDGAVAVFDAVAGVEPQSEAVWRQADRHAVPRIAFVNKLDRAGADLDQAVRSIRERLRTVPLVVQLPVGQEDGFTGVVDLLRMRSLIWTAGRDTYEQGPVPDDLLTEAARRRRLLEEAVAELHPEALEEFCERSALSERTLTGALRDLTRSGEGVVVLCGSAYRNCGIEPLLEAVVAYLPSPPDVPPVRGSRDGARQERPADPQAPFAGLVFKVNSTATGRLTYVRVYSGTLRKGDTVLDVGAGRSERIGRILRVQADRHAEVDRAEAGDIVAVIGPKAARSGATLSTPDAPLLLEPPTAAAPVVTVAVEARSRLDTDRLATALARLVEEDPSLTARTDPETGQTVLSGMGELHLEVAVEKIRRAHGLEVGVGRPQVAYRETVVRGVTGLVYRHVKQDGGAGQFAHVVLDVAPLDPDDDRAEGFAFSSTVTGGRVPQEFVRAVEAGCRDALAEGPLGGHPVTGLRVTLTDGATHSKDSSETAFRAAGRFGLREALRTGVMALLEPVVEVTVTVPDDAVGTVLGDLAARRGRVSGQETRSGTAVVTATVPLAELFGYANRLRSRTQGRGTFTTRPAGYAPAPASVTGGVLSP
>NZ_CP011340.1|WP_005310771.1|2280713_2281307_+|hypothetical-protein
MWFAAGVTQDLEIVAFESAEAFQAWLGENHADSPGIWLKLRKKGPGIAALDYTQALDAALCYGWIDGQKAKFDDQWWLQRFTPRKLRSKWSKANRDKVAALIEQGRMRPPGQAEVDRAKADGRWEAAYDGAKTATVPDDLTAALTADPAAAEFFETLDRQNRYAILYRIQDAKKAETRARRIEKYVAMLAKGEKLHP
>NZ_CP011340.1|WP_078535230.1|2279370_2279577_-|hypothetical-protein
MKTHHSRQRFNDPGGFEHYVKDVDPNALEYYVDGVINDGGTVFTFKEGKTYIDEFQQYGKVPARAQHP
>NZ_CP011340.1|WP_005310769.1|2278952_2279387_-|hypothetical-protein
MHSTHDATMTAEQFSTVFQVTKEFNSIPEDVVLESGFPVQSPSEILELARRIRKSLLAGPVDVHFVSPSASDSRTLRISASAGEQGHGAASTGEVPLAAGQLWRPLIDVAVATLGEKELRFRTGFTKDEVASAAAPLDDLFAVQ
>NZ_CP011340.1|WP_005310765.1|2275667_2276468_-|M23-family-metallopeptidase
MRFLRRLSAVVAAVVLALTGLSAAPAYAGESAAAAGPNFKAPYPCGQRWTYSHHSAEVRRALDFVRADGGTTAGTPVLASAAGTATRHYQAGGAGNYIVIDHGGGWKTYYFHLAAYSVASGEYVAQGRQIGTTGSTGNSSGAHIHYEQLYNGVGQNIVINGSGLSYPGSYHQAYLTSDNGCGGTGTPFNTWGSGVNVRADARLSAPVVTTLAGPTAVRVLCQKQGDTVNAEGYTNNWWSKLRDQNGFISNIYIDHPDAVLPGVPLC
>NZ_CP011340.1|WP_037773554.1|2274505_2275507_-|helix-turn-helix-domain-containing-protein
MLRVDFSSGELSRLRVAPGVDPLWETALSLHLLQNRQAALAFDPWRHEARAALARAGLVPATRALMGLCPPSGYFPDFLTPGCGDTDLDTALDRLLATPRRRLAAELSRLYADSGRAVPPGVRPLAEGRPEALRRLAWALRGYYTAAVEPYLSVMRAQAAADRAARADAALVHGAEGLLTGYDELPGWQCASGRLRAPYPVDRELRLEGRSLTLVPAFFCVRAPLALVDEELPPVLVHPLSPEPQWLARARRAEPLSSVAQLIGASRARLLRQLDRPMTTTGIAAALGLAASTASRHVSVLRDAGLLSSHRQGIRVLHRRTRLGDDLLAGAPH
>NZ_CP011340.1|WP_005310761.1|2272851_2274330_-|glutamate--cysteine-ligase
MGRDVPALVFTRDDRRRYREKMQSCLDTFALMLREARFESERPQVGLEIELNLVDEAGEPAMRNTDVLEAIADPAWSSELGRFNLEINIPPRTLTAGGPDSWEREIRDALNHAEERASEVGAHLAMIGILPTLRQRDVGEAALSENPRYRLLNEQVFAARGEDLRIAVDGVDRLRTYADTITPEAACTSTQFHLQVSPGEFAAYWNAAQAVAGVQVALAANSPFLFGKELWRETRIPLFEQATDTRPEEIKVQGVRPRVWFGERWINSVFDLFEENVRYFPALLPLCDEEDPRATLDGGDVPELPELTLHNGTIYRWNRPIYAVANGRPHLRVENRVLPAGPTVADVLANGAFYYGLTRALVDEERPVWSRMSFQAAEDNLHAAARHGIDAGLYWPGMGEVPAPELVLRRLLPMAHRGLELSGMDSAWREPLLGIIEQRCVTARNGAVWQAEMYHHIDSTSRVDHHEALRRMTRQYIDYMHLNAPAHTWPVE
>NZ_CP011340.1|WP_037773553.1|2269466_2272124_-|xyloglucanase
MAAFALTAGLFTAGSPAVARSGESAPVAEPSDVSTAADTYTWKNVRIDGGGFVPGIVFNRSEKDLAYARTDIGGAYRWNEAGKEWTPLLDWVDWDRWGWTGVVSLASDTVDPDKVYAAVGTYTNSWDPTNGAVLRSSDRGASWQATTLPFKLGGNMPGRGMGERLAVDPNKNSVLYLGAPSGHGLWRSTDSGVTWSKVTAFPNPGNYAQDPTDTSGYANDNQGVVWVTFDERSGSAGSATQHIYVGVADKENTVYRSTDGGATWSRIAGQPTGYLAHKGVLDSGTGHLHLTLSDTGGPYDGAKGRIARYDTATGEWKDTSPTAEADTYSGFSGLSVDRQRPGTLMATAYSSWWPDTQIFRSTDSGETWTRAWDYTSYPDRSFRYTQDISSVPWLSWGANPSPPEVTPKLGWMTEALEIDPFDSDRMMYGTGATVYGSENLRTWDSGGRITITPMVKGLEETAVNDLVSPPSGAPLLSALGDIGGFRHTDLDAVPPLMFTSPNLSSTTSLDFAEAAPATVVRVGNADAAPHIGFSTDNGANWFQGSQPSGVTGGGTVAAAADGSGFVWSPDGAGVHHTTGYGSSWKASTGIPAGATVESDRKNPKKFYGYKAGTFYVSQDGGATFTAKASSGLPQEGNVRFKALPGAEGDVWLAGGTASGTYGLWHSTDSGATFRRVEGVEQADAVGFGKAAPGASYQTIFVSAKIGGVRGIFRSTNGGADWTRINDDAHQWGWTGAAITGDPRVYGRVYVSTNGRGIQYGESSDGGGTDPDPDPDPPGDAGCSVAYKITNQWSGGFQAEVTLTNKGDAALDGWQLRWSFPDGQTVGQMWNAAHRQSGAEVTAENVSWNGKVAAGASVSFGFTGGWSGRNTAPSAFTSGGENCTTG
>NZ_CP011340.1|WP_005310753.1|2267998_2268877_-|transglycosylase-SLT-domain-containing-protein
MPAKGKHRRPKSRSLTRGLVAAGTGGAALALPLIGGTAAHAAPAAAPAAAERTVAPAKTVAAAAQAVAKKAGTVTYSVVAGDSLYKIAEEHSLNGGWKQLYKDNRKAVGADPALIHPGLRLTIGAKAEAAPKAKPQAEAKAAPKAAEEAETSEKAERAAETARADRSERKSAPVAQAAAAPAKPAYANNLDGWIRESLDVMAQHGIPGSYEGIHRNIMRESSGNPLAINNWDINAINGTPSKGLLQVIQPTFDAYHVEGTAYDLFDPVANITAACNYAADRYGSIDNVNGPY
>NZ_CP011340.1|WP_005310751.1|2267024_2267282_-|hypothetical-protein
MSRATRCTAAASAVAAAFLGGILLASPAQAAEAPRTAPAAADDFVWPTPSDLDDIVCPALPLLPDLPALPDRPGRPGMPDDFVWP
>NZ_CP011340.1|WP_005310775.1|2284449_2284923_+|MarR-family-transcriptional-regulator
MPGSALPSQDLDRVASALAATLPVLQRAIERRVDLESPHVKPPEGQLALLRFVARYEGTTVREAAQALLMKPNNVSALISQLTGRGLLERRQDDADKRIVRLHLTPTARRELAAVRRIENAHLTRALRALTEGEMDALGSAVGALTSLTRHLHSAGA
>NZ_CP011340.1|WP_005310777.1|2285089_2286682_+|MFS-transporter
MPSTTVDHSPLPTSPGPDTARPGRLRSNPWLTLLAVACGLFMVQLDGSVVAIANPEIGRDLNASTADLQWVTNSYLLALAAALILGGKLGDRFGRRTFYMIGLAGFTAASLAIGLAGSIEGVVVFRAFQGLFGAMLVPNTLGLLRAVFPGNKFAMAVGIWAMVASVATALGPIVGGLLVEHVSWESVFYINLPIGLVTLAFSATVLPQSRNAGGHHRFDIPGVALLALGLLSLVFGVVKGETWGWTSAGTLGTVLAGVAVLVLFGRYESRTEHPLLPMRLFRSPALAVGTVVTALNFFVMLGVIFFVMLYLQNVRGFTPVEAGVRTLPLSIASLLAAPLGAALTGRFGPRVVMPLGMLLQAGATFGMLTWDADSSYTALWPPFIALGLGVGMVLSASSDAIVGNAPVKDGGVAGGLQATALQVGGALGTSVLVSLITGRVGSTLQEELTRAGVAPAVAGRLHEAKDAVAMGIAPVSGDMPAPLRAAVVEGSGQAFMNGAHTAVLVTGVLCVLGAVVAAAGIRRSPQAAGH
>NZ_CP011340.1|WP_037776201.1|2286733_2287369_-|GNAT-family-N-acetyltransferase
MDLVPFVRRYRPSDRAALADICVRTAHEGGDSTSLYPDPGLMPSLFAFPYVELEPAFAFVLDDGTGQAVGYILGAPDTPRFAERFRAEWLPLVSERYPEPEGEPTTPVEEMLVLLHRPERMVLPELTSFPAHLHIDLLPRWQRRGFGRALMRALLDALEAAGVPAVHLCMVRANTAARAFYGRLGFREIDVPDPGPVLYLGRPTARAGSAA
>NZ_CP011340.1|WP_053557717.1|2287657_2288479_+|helix-turn-helix-domain-containing-protein
MNGPTGATEPESSDSLKAFGEVVKAFRKRARLTQEQFAPRVRYSVPTVASIEQGRRFPPASFVDRAEEVLDAFGALRGAARHLSRRPGLASWFRQWAQLEAESVNLCTYECRLIPGLLQTEAYARTLFSERLPPLGDDQIEARLSARTERQRLLRERPNTAFSFIVEEHVLQRGVGASPELLPHVLELAALRNIEVQVMPQKRVTHAGIDGPMQLLETPDNTWYGYCEGQESGQLISDAKVVSMLQMRYARMRSQALSLEDSLSLLRRMRGAA
>NZ_CP011340.1|WP_005310783.1|2288475_2288661_+|DUF397-domain-containing-protein
MSTTELAWFKSSYSGSSGDSCVEVATTPATVHVRDSKVEQSPELAVSPASWTSFVSYAAQD
>NZ_CP011340.1|WP_053556853.1|2288736_2289609_-|biotin-dependent-carboxyltransferase-family-protein
MSGGTLDVVRAGALTTVQDLGRSGHAGLGVPRAGALDRPAHLLANRLVGNPADAATLETTLTGVAVRTDRPAVAAVTGAPAPVRVNGRPAAWGTAVHLPAGAVLDVGAPTSGLRSYVAVDGGIAVAPVLGSRSTDLLSGLGPATLRDGGTLPLGEPTGEPLYADTLLWEAPPKELVLPVLLGPRDDWFTAAAVSTLATGRYEISQHSNRIALRLEGPPLERAVHREMPSEGMVVGAVQVPPDGRPVVFLADCPTTGGYPVIGVVPESLLYPAAQAAPGLTVRFVPRRHRR
>NZ_CP011340.1|WP_053556854.1|2289605_2290286_-|allophanate-hydrolase-subunit-1
MRLRPVGEDSLLVDLDTPEEAQAWHARILDRCGRGTPAPVRDIVPGDRTVLLYKVTDVRALEAELRRWSVPLSAAGSGPLVEIPVHYDGADLGAVAGLWGVTEDEVARIHSGTEHRVAFCGFSPGFAYMLGLGERYQVPRRSAPRTSVPAGSVALAGPYTGVYPRASPGGWQLIGTTPVRLWDLEREPAALLTPGTRVRFVPQEAAPTQAATPEDPSAAATRKRTV
>NZ_CP011340.1|WP_050791461.1|2290282_2291089_-|LamB/YcsF-family-protein
MVPPDRRTVPRSQAVTDLVIDLNADLGEGFGRWTLTDDEALLSLVTSANVACGFHAGDPGTMRRVCETAAERGVRIGAQVSYRDLAGFGRRAMDVPADELADEVAYQIGALQVFARAAGAAVSYVKPHGALYNRVVADHEQAAAVAAGARLADPGLVVLCLPDSAMHAQAARVGLPVAAEAFADRAYTAAGTLVPRATPGAVITDPAEVAHRAVALAREGRVTALTGEPVGVRARSLCLHGDTPGAVAAAERVRAALDDAGVRVEAFV
>NZ_CP011340.1|WP_005310790.1|2291280_2291976_+|GntR-family-transcriptional-regulator
MTAEVDPAVLAGDRALLGRSSTADRVADILRTRISEGYLPPGSKLSEDAIGGALGISRNTLREAFRLLTHERLLVHELNRGVFVRMLTVQDVTDIYQVRRIIECAAVRGLGAPPYDLGHAEAAVAEGEKAAKEGAWRDLGTANIHFHHAVVALARSRRLDDLMRGILAELRLVFHAMDNPRGFHEPYLERNREILSALRAADRAKAELLLAAYLDDAEQQLVERYSELLGQ
>NZ_CP011340.1|WP_005310792.1|2292369_2293164_+|metalloregulator-ArsR/SmtB-family-transcription-factor
MSDEATATDRIFKALADPTRRLLLDRLREHNGQTLQQLCEHLAMARQSATQHLDVLVRAGLVIVVRRGRERLHYLDPGPIHRIEERWISEFDRPRLQALSAIKHKAEEYAMTDASPSVPTYVYVTYIRASAEQVWKALTDADLTARFWGHANVSDWQPGSTWEHRRVDGSDKVDVVGRVIESEPPKRLVITFEDPQGAGSPEGASVVTFLVEPHQDIVRLTVTHENLPDQEMLDGISQGWPAVLANLKSLLETGEVLPQAPWDM

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Crispr_ID: NZ_CP011340_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_8

2449064-2449155

Orphan

Consensus_repeat	Method
CCGCAGCCACTTCATGCCATGCCAAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_8

>merge|NZ_CP011340|8|2449064-2449155|CRISPRCasFinder
CCGCAGCCACTTCATGCCATGCCAAGCCGTCCGCTCTACGGGGCCCTGCCCGCAGCCCTGCAGCCCGCAGCCACTTCATGCCGTGCCAAGCC

>NZ_CP011340|8|7|2449064-2449155|CRISPRCasFinder
CCGCAGCCACTTCATGCCATGCCAAGCC	GTCCGCTCTACGGGGCCCTGCCCGCAGCCCTGCAGC
CCGCAGCCACTTCATGCCGTGCCAAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_005311052.1\|2459641_2460301_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP011340.1\|WP_005311024.1\|2442776_2443604_-\|serine-protease	unknown	unknown	gnl\|CDD\|238113
NZ_CP011340.1\|WP_037776227.1\|2456331_2456979_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NZ_CP011340.1\|WP_005311049.1\|2457100_2458654_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP011340.1\|WP_005311014.1\|2437888_2438563_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP011340.1\|WP_005311030.1\|2446699_2448667_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP011340.1\|WP_005311044.1\|2455577_2456279_-\|ribonuclease-HII	unknown	unknown	gnl\|CDD\|234574
NZ_CP011340.1\|WP_037773591.1\|2437315_2437792_-\|DUF485-domain-containing-protein	unknown	unknown	gnl\|CDD\|377315
NZ_CP011340.1\|WP_005311033.1\|2449192_2449957_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NZ_CP011340.1\|WP_078535238.1\|2435696_2437355_-\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
NZ_CP011340.1\|WP_005311042.1\|2454873_2455494_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP011340.1\|WP_053556871.1\|2450303_2451665_-\|DUF4192-domain-containing-protein	unknown	unknown	gnl\|CDD\|379390
NZ_CP011340.1\|WP_005311028.1\|2445652_2446540_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP011340.1\|WP_005311039.1\|2454165_2454795_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005311026.1\|2443764_2445315_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|235640
NZ_CP011340.1\|WP_005311050.1\|2458714_2459629_-\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NZ_CP011340.1\|WP_005311020.1\|2442416_2442647_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005311037.1\|2451775_2453947_+\|RecQ-family-ATP-dependent-DNA-helicase	unknown	unknown	gnl\|CDD\|223588
NZ_CP011340.1\|WP_005311016.1\|2438559_2439738_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP011340.1\|WP_005311018.1\|2439856_2441983_-\|type-IIA-DNA-topoisomerase-subunit-B	unknown	unknown	gnl\|CDD\|235501

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_005311024.1\|2442776_2443604_-\|serine-protease	gnl\|CDD\|238113	cd00190, Tryp_SPc, Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.	4.66132e-66
NZ_CP011340.1\|WP_037776227.1\|2456331_2456979_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	4.18151e-17
NZ_CP011340.1\|WP_005311049.1\|2457100_2458654_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.90854e-66
NZ_CP011340.1\|WP_005311014.1\|2437888_2438563_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	7.44787e-75
NZ_CP011340.1\|WP_005311030.1\|2446699_2448667_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.86349e-47
NZ_CP011340.1\|WP_005311044.1\|2455577_2456279_-\|ribonuclease-HII	gnl\|CDD\|234574	PRK00015, rnhB, ribonuclease HII; Validated.	1.92134e-83
NZ_CP011340.1\|WP_037773591.1\|2437315_2437792_-\|DUF485-domain-containing-protein	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	7.77774e-30
NZ_CP011340.1\|WP_005311033.1\|2449192_2449957_-\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	2.72791e-27
NZ_CP011340.1\|WP_078535238.1\|2435696_2437355_-\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	1.0705e-174
NZ_CP011340.1\|WP_005311042.1\|2454873_2455494_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00024836
NZ_CP011340.1\|WP_053556871.1\|2450303_2451665_-\|DUF4192-domain-containing-protein	gnl\|CDD\|379390	pfam13830, DUF4192, Domain of unknown function (DUF4192).	2.67016e-79
NZ_CP011340.1\|WP_005311028.1\|2445652_2446540_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	8.66606e-44
NZ_CP011340.1\|WP_005311018.1\|2439856_2441983_-\|type-IIA-DNA-topoisomerase-subunit-B	gnl\|CDD\|235501	PRK05559, PRK05559, DNA topoisomerase IV subunit B; Reviewed.	0
NZ_CP011340.1\|WP_005311050.1\|2458714_2459629_-\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	1.84282e-45
NZ_CP011340.1\|WP_005311052.1\|2459641_2460301_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	3.94339e-33
NZ_CP011340.1\|WP_005311037.1\|2451775_2453947_+\|RecQ-family-ATP-dependent-DNA-helicase	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	1.46697e-131
NZ_CP011340.1\|WP_005311016.1\|2438559_2439738_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.30387e-36
NZ_CP011340.1\|WP_005311026.1\|2443764_2445315_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	0

>NZ_CP011340.1|WP_005311030.1|2446699_2448667_-|ATP-binding-cassette-domain-containing-protein
MLQAIGLTSTRRRKHPPAVDDLTFEARAGQITVLLGSSGAGKTTALRLVLGLEAGRGFTYFRGNPLHRIANPACEVGALLGDVPGHPARTARGQLRMLSAAVGVPASRADELLDVVGLAGLAQEPLGRLSLGMDRRLGLASALLGDPQTLVLDDPVRGLSPRDRSWLFALLRAHAAQGGTVLCTLREPKEAARIADRVVTLHEGRLLADQEAAEFSRTRLRPRVAVRTPHAARLSAVLAREARAERRSVEVVAVGGGVLAVFGSSCAEVGETAFRHGVLVHRLTEEVGDTPPAPEPEPQPQPQPQPQPQPQPQSGPVAGTSPAPGPAPPVPSPASRATAPALSATSAPPATPVPYPSLVPARTPTPALTSTPASTPTRTRTPTDSATPAAVPRAPRPVRSPRWPLRYELRRLLGVRTSPLIGLAAVAASLALCLVLARTGATALKPHTVAAWPGFLPLPPAAFGAGLIGALSFGEEFRHPALASARGTVPRRLGLLLAKLGVTAAAAVTLAALVVAVDVQALRLAFGPELVALPSDWPALAAGWGALCVGCAWSGLLAAGVFRVTAAGVAAVLAVPVVVAPLAHKVLVVPAVRSIVGLPGRLRELAWVELPQEADRWLIAAMRLPAQPVGVALVLSLVALICAYVFTGLRRRAFW
>NZ_CP011340.1|WP_005311028.1|2445652_2446540_-|FadR-family-transcriptional-regulator
MSTLAHTMMPPARPAETGMAGPGELDRYGYGESPAADRVGPPAWEASDTELGRVGRRTAGSRGRGLHGQLVQQLGQMIVSGDLGADRPLVPEEIGQRFEVSRTVVRESLRVLEAKGLVSARPNVGTRVRPVSDWNLLDPDIIEWRAFGPQRDDQRRELSELRWTIEPLAARLAAGHGREDVQQRLGDMVEIMGHALAQGDGLTFSRADAEFHSLLIQLAGNRMLEHLSGIVSAALQVSGGPITGCDRPTEASLSHHAHIAEALASGDAHAAESAMRRLLTVHPEVERVVPAPREH
>NZ_CP011340.1|WP_005311026.1|2443764_2445315_-|RNA-polymerase-sigma-factor
MSASTSRTLPPEIAESESVMALIERGKADGQIAGDDVRRAFEADQIPPTQWKNVLRSLNQILEEEGVTLMVSAAESPKRARKSVAAKSPAKRTATKTVAAKTTTAKTVAASTAPTAETVEVAADESETAPAKKAAAKKATAKKTAAKKTTAKKTAAKKTTAKKDSDDAEGEELLDEVQPAGKGDEEEPEGESKGFVLSDDDEDDAPAQQVAVAGATADPVKDYLKQIGKVPLLNAEQEVELAKRIEAGLFAEDKLANSDKLAPKLKRELEIIAEDGRRAKNHLLEANLRLVVSLAKRYTGRGMLFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLARVQRQMLQDLGREPTPEELAKELDMTPEKVIEVQKYGREPISLHTPLGEDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHSVLDTLSEREAGVVSMRFGLTDGQPKTLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
>NZ_CP011340.1|WP_005311024.1|2442776_2443604_-|serine-protease
MRRPTARSLAGVPALIAAAVVTTPAMSVPAAADSVVVGGYEVRADDSPWVVALASRDRFGPARSGQFCGGVVVAPTKVMTAAHCLSNAVLGKDAASVRDLRVIAGRSELAGNGGREVPVRETWVTPAYDPVTNSADMALLTLGEALPEDHVLPVAGPGDPAYEVGTAATVYGWGDTQGNGSYASSLRAARVSVLPDETCANAYPGGQGSRYAPSTMLCAGDPQGGHDACQGDSGGPLVAEGRLIGLVSWGSGCGRPDGPGVYTRVSAVVRSAGTG
>NZ_CP011340.1|WP_005311020.1|2442416_2442647_+|hypothetical-protein
MTTVLTPASPLTAADRCDRCGAQAYLRVVLISGGELLFCAHHGRKFEPELKKIAAEIQDETDRLTAVPADTGEEDH
>NZ_CP011340.1|WP_005311018.1|2439856_2441983_-|type-IIA-DNA-topoisomerase-subunit-B
MTAESSVPSTALLTADRDGSNYTARHLLVLEGLEAVRKRPGMYIGSTDSRGLLHCLWEIIDNSVDEALGGHCDHIEVILHEDGSVEVRDNGRGIPVDVEPKTGLSGVEVVMTKLHAGGKFGGGSYAASGGLHGVGASVVNALSARLDVEVDRGGATHMISFRRGVPGIFTESGPDAPFDPANGLRKGKRVPKARTGTRVRYWADRQIFLKDAKLSLETLHQRARQTAFLVPGLTIVVHDERGLTEAGGEGKSVETFRFDGGISEFCEYLAQDKPVCDVLRLTGQGTFKETVPVLDDRGHMTPTEVTRELGVDIALRWGTGYDTNLKSFVNIIATPKGGTHVTGFERSVTKTMNEVLRSAKMLRVAEDDIVKDDALEGLTAVVTVRLAEPQFEGQTKEVLGTSAANRIVANVVAKELKAFLTSTKRDAKAQARAVLEKAVAAARTRIAARQHKEAQRRKTALESSSLPAKLADCRSDDVERSELFIVEGDSALGTAKLARNSEFQALLPIRGKILNVQKSSVSDMLKNAECGAIIQVIGAGSGRTFDIDAARYGKIVLLVDADVDGAHIRCLLLTLFQRYMRPMVEAGRVFAAVPPLHRIELIQPKKGQDKYVYTYSDNELRQTLLEFQRKGVRFKDSIQRYKGLGEMDADQLAETTMDPRHRTLRRINIGDLESSEQIFDLLMGNEVAPRKEFITSSAATLDRSRIDA
>NZ_CP011340.1|WP_005311016.1|2438559_2439738_-|two-component-sensor-histidine-kinase
MPSSKWTEWPTRESLSRIGVPRARIALDIALLAALSSWAVASAYTSEIFHGWGAVLPPLGLLGCAAAAARYHRTTLDNRLPASLALLGVIAVTGLGAHAAGADVPAMVLWVSVALMAIERLPVAAVVAIVTLPVAGFVMTEDSRLGALLTTAAVVLGGCALRLDAHARGAGFRLLAQERAAREAEAVSAALAERARIAREIHDVLAHSLSAQLVHLEAARLQIERGPQGPFRDQILERVVAARGMAREGLAETRQALSALRGEMVPVEEYLRELAESGPVSTEVTGARRRLSADASQAVRRVAQEAMTNVRKHAPGAVVRMLLAYRDGEVVLEVRDSGRPAAADGPEVSGELGGSGAGYGLLGMRERAELLGGTLEAGPEGEGFVVRLRVPA
>NZ_CP011340.1|WP_005311014.1|2437888_2438563_-|response-regulator-transcription-factor
MTGETARVVVADDQAVVREGIVMLLGLLPGIEVVGSARDGEEALTLVAELAPDVVLMDLRMPRVDGVEATRRIRSEHPGTQVVVLTTYADDDSLFPALRAGARGYLTKDADGDEIVRAIQDVVAGRAGLSPVVQRRLLEQVTAEPPPTGPRLPDGLTAREGEVLTLIAEGLGNTDIAARLGISTATVKTHINNLFAKAGLHDRAQAVRYAYREGLAKPPGTNVT
>NZ_CP011340.1|WP_037773591.1|2437315_2437792_-|DUF485-domain-containing-protein
MEKQEGPEAAQVRLEDPWYDALASGWSDRDSTGAPAPGGHPAAEDGPAGPSAADIYLEVQRSEAFQEVRARYRRFVVPASAAFLVWYLAYVVAATTAPGLMARPVAGAVNVAMVAGLAQFLTTFLLTWAYTRHARLRRDRAALDLRWDTQEMTRGAGR
>NZ_CP011340.1|WP_078535238.1|2435696_2437355_-|cation-acetate-symporter
MGHAGDDERGRALNGDHQALALLLFSAFIAVTLGITTWVSRNRHGSAEEFYAGGRLFSPMENGFAIAGDYMSAASFLGISGLIALYGYDGMLYSVGFLVAWLVVLLLVAELVRNCGRFTLADVVAARMKERPVRIAAGTSSVTVSVLYLVAQMVGAGSLVALLLGGTSEAARSWTVIGVGALMVIYVSMGGMRATTWIQIVKAVLLMAGAIAMTVLVLMRFHGDFNQLLDSAAARSGHGKDFLAPGLRYGGDWTARLDFISLGLALVLGTAGLPHILSRFYTVPTARAARRSVVWSIGLIGSFYLMTIVLGFGAAAVVGAEEVRASNAAGNTAVPLLALDLGGGAGSTGGAVLFAIVAAVAFATILAVVAGITLASSASVAHDLYATLRRRRADGPTGEEAGGGRYSEVAVARIAAVCIGAVAIALGLLARDLNVAFLVGLAFAVAASANLPVLLYSLFWRNFTTRGAVWSVYGGLVPAVLLVLVSPVVSGSERALFPGVDFHVFPLENPGLVSIPLGFLAGWIGTVVSSEPPDAAKHAETEVRALTGAGAV
>NZ_CP011340.1|WP_005311033.1|2449192_2449957_-|NUDIX-hydrolase
MSPYDPSAFPPFAVTVDLVVLTVRRHALCALVVRRGEPPFQGRWALPGGFVRGDEDLAAAAARELAEETGLCAHDPASPGSANGAHLEQLATYGDPKRDPRMRVVSVAHLVLAPDLPAPRAGGDANSARWAPVEELLDREAAFAREEEQQAPLAFDHALILADGVERARSKIEYSSLATAFCPPEFTVGELRRVYEAVWGVALDPRNFHRKVTGTPGFLVPAGGTTTRQGGRPAQLFRAGGATILNPPMLRPEV
>NZ_CP011340.1|WP_053556871.1|2450303_2451665_-|DUF4192-domain-containing-protein
MNKHHDLTGSGPDQQITLRGPGELADALPYMMGFHPTDSIVLVALHGSNGRFGGRLRLGIPRSPREWEPVAAQLAECLIRGSGRRGPRPDGIVVFLCQDPVGDETGDRVMERLRPLAQRLRTACGGLDVPVYEALCISDGRFWSYCCPDARCCPTDGTPLALPGTSVMAAAAAYAGVRVRGSLRDMERRFAPPPGPAAEDQVRALDAAGAALTSRILDAQGRQGVADETVALARLLLERMAQAPRTDGDAAADAEDDRLVSDDEAAAVILGLQDRETRDRAAQWMEGEEAAPALRLWRVLSRRCAAPYTEHAAATLTLAGWVSWSVGDEPGARVALGLALRADPEYVFARLLHQACNEGLDPETVRRCLRSQRDVPPQVPSSPCPDDHRTAAGRRPRTRVVRPSAAEPDRAGSHRTHPRSGATPGRPRHGTAAARARTRAARRGGQRGARSGR
>NZ_CP011340.1|WP_005311037.1|2451775_2453947_+|RecQ-family-ATP-dependent-DNA-helicase
MTNADRVELRASADSVLARLVSDTSGRARLREDQWRAIEALVADKRRALVVQRTGWGKSAVYFVATSLLRARGSGPTVIVSPLLALMRNQVEAAARAGIRARSINSSNTEEWETIQSEVAAGEVDVLLVSPERLNNPDFRDQVLPRLSAATGLLVVDEAHCISDWGHDFRPDYRRLRTMLAELPAGVPVLATTATANARVTADVAEQLGTGAGTDALVLRGPLDRESLSLGVLQLPDAASRLAWLADHLGELPGSGIIYTLTVAAAEEVTAYLRQCGHTVTSYTGRTENADRQQAEEDLLANRVKALVATSALGMGFDKPDLGFVVHLGSPSSPIAYYQQVGRAGRGVEHAEVLLLPGKEDEAIWQYFASVAFPPEELVRRTLDVLAQADRPLSLPALEPLVELRRTRLETMLKVLDVDGAVRRVKGGWTTTGQPWSYDSERYAWVARQRASEQQAMREYARSTGCRMEFLRRQLDDEEATPCGRCDNCAGARFSDKVSAGALDAARGELGRPGVDVEPRKMWPTGLAAVGVTLKGRIPEGEQSFTGRALGRLSDIGWGNRLRPMFAPQAPDGPVPDDMADAVVTVLADWAKGPGGWASGDVDAPARPVGVVTIASRTRPRLIGSLGSRIGQVGRMPVLGTVEYVPEALEAHVSRTNSAQRVRALHEALVVPPQLAEALTAAGGPVLLVDDYSESGWTLAVASRLLRRAGAPGVFPLVLAVQS
>NZ_CP011340.1|WP_005311039.1|2454165_2454795_+|hypothetical-protein
MTFGFASSAATSITASANSANRLARLLEPAEWAAAGIPLLRNPREVVGGLHARHRPAPATAVVAVLDHEERLAASASFSRRAVPADGWEFRNALLAHLRRVIPHDLRRRTPVRTAVLLYCREGDERWTEEDGAWMWGLRDACTLHGLRCGAYITLTRGGWQVLGEGRGGRHPNSTSSPGRLADAGTDTDHVPLRTAGGAVDALRRTAAR
>NZ_CP011340.1|WP_005311042.1|2454873_2455494_-|hypothetical-protein
MPLIPEEPHIHESAQGPRVTPATGRTAPTPRPVPGPRSAASPRPGHPGPGPSRPAPPAQRAAGAAGKPEPSRPETRSTPQIQLVPAPADGALDAADEAVDLLLDSGRAPGDVLVFTTGDQHPWAAHELSFGEGTYWAQHDARDDVFYADASSVERAAARPVVVFAVNGGTDDSTARALPAALEKASALLIVCGDPARINAVLGAGV
>NZ_CP011340.1|WP_005311044.1|2455577_2456279_-|ribonuclease-HII
MAYEPPTHAVERSIRATTGAKIVAGIDEVGRGAWAGPVTVCAAVTGLRRPPVGLTDSKLITPKRRAEMAELLEGWVTAHALGHASPEEIDELGMTAALRLAAGRALEGLPVRPDAIILDGKHDYLGVPWQVRTVIKGDQSCVAVAAASVIAKVHRDAMMAQLPEEFTAFGFADNAGYPSPVHKAALRELGPTPYHRLSWAYLDYLPQWRHLKKVRLSPEAAELESGGQLGFDF
>NZ_CP011340.1|WP_037776227.1|2456331_2456979_-|TetR/AcrR-family-transcriptional-regulator
MATSRWTGAAEVPPVPLRRRGPVLERAILEAALEQLSTVGWSGLTMEGVAASAQTGKAAVYRRWPSKEDLVADALEAGLPSLDEAVDHGSVREDLLHVCRRVRDAMFSRTGIALRSVLYECDTATAERFQSLINTRVIEPSTELFREVVHRGVRRGDVRPDAACELVLDVIPGLLMYRSKICGSDWPDPDIAEMIDQVMVPLLRPHSCPPVSRGT
>NZ_CP011340.1|WP_005311049.1|2457100_2458654_+|MFS-transporter
MTTSQLTAPERPGAARRQGRPGIALAVIAALQLMVVLDTTIVNIALPHIQGALEFTTTQLSWVVNAYTLTFGGLLLLGGRAGDILGRRRVFISGVLLFTFASLLCGIAQEPWQMLAARALQGVGGAIASPTALALITTTFREGPERNRAFGIFAAVSASGAAIGLLAGGMLTEWLDWRWVFYVNLPIGILIAVLAPMFINESERNPGRFDVTGALTSTAGMASLVYGFIRASEDGWSDGLTLGAFAASVVLLTAFVLTERRTRDPITPLRMFADRNRSGTYLIMMSLAAAMFGMFFFIVLFVQNVLDYSPIASGLAFLPVTVAIMTAAGLSTKLLPVLGPKPFLTAGAVLTGSGMAWLTLISPDSSYAGGVLGPMLLFGFGMGLVFVTATLTAVSGVAQHESGAASSLLNATQMVGGSLGLSILMTVFGAAGREEAERQMPSFLAESTPAQQEAFARTHELPPPWGHQVLAEGIATAFWAGVGLVALAVVTAVLVIRVRKSDLEALSGAAGPGGHAA
>NZ_CP011340.1|WP_005311050.1|2458714_2459629_-|ADP-ribosylglycohydrolase-family-protein
MTADSASDQRFARALDSLRGLSVGDALGSQFFVPSNYPLLKRRELPPSLWQWTDDTEMACSVLAVLVEHHRVDQDALARSFAEHHDFDRGYGPAVNRLLRLIREGGDWRELAAGLFKGQGSWGNGSAMRIAPLGAWYADDPEQATHQAEISSYPTHQHREAVVGAMAVAAAAALAADPAGPPAPADLLDGVVALVPRSAVGAGLRRARDMLDYDDAGTVAAVLGCGRRTSAHDTVPFALWSAARSLGDFEQAFWTTAQVGGDVDTTCAIACGVVAASKGGQPPAAWLEKTEELPDWLPGPDRLG
>NZ_CP011340.1|WP_005311052.1|2459641_2460301_-|histidine-phosphatase-family-protein
MARPRRIVLVRHGESVGNADDTVYEREPDHALQLTAAGLAQAAETGAHLRDLFGRERVSVYVSPYRRTHETFQAFALDPELVRVREEPRLREQDWGNWQDREDVRLQKAYRDAYGHFFYRFAQGESGADVYDRVGAFLESLHRSFAAPDHPPNVLLVTHGLTMRLFCMRWFHWSVAEFESLSNPGNGETRTLQLGDDGRYHLDRPFEQWRTPEPYGTTG

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Crispr_ID: NZ_CP011340_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_9

3409609-3409761

Orphan

Consensus_repeat	Method
CGCAGGTACCCGTCCCTGCCGACGAAACGGCGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP011340_9

>merge|NZ_CP011340|9|3409609-3409761|CRISPRCasFinder
CGCGGGAACCCGTCCCGGTCGGCCAGGCGGCGCAGGTACCCGTCCCTGCCGACGAAACGGCGCGGGTGCCCCACCCCGCCGGCAAGGCGACGCGAGTTCCCGTCCCCGCCGGCAAGGTCACGCAGGTACCCGTCCCCGCCGACGAAACGGCGC

>NZ_CP011340|9|8|3409609-3409761|CRISPRCasFinder
CGCGGGAACCCGTCCCGGTCGGCCAGGCGGCGC	AGGTACCCGTCCCTGCCGACGAAACGG
CGCGGGTGCCCCACCCCGCCGGCAAGGCGACGC	GAGTTCCCGTCCCCGCCGGCAAGGTCA
CGCAGGTACCCGTCCCCGCCGACGAAACGGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_005312776.1\|3416865_3417276_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005312772.1\|3415587_3415998_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_037773875.1\|3417881_3418715_-\|putative-protein-N(5)-glutamine-methyltransferase	unknown	unknown	gnl\|CDD\|274733
NZ_CP011340.1\|WP_078951357.1\|3407508_3409197_-\|virulence-factor-MviN	unknown	unknown	gnl\|CDD\|240528
NZ_CP011340.1\|WP_005312732.1\|3398782_3399301_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_053556981.1\|3405594_3406752_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340836
NZ_CP011340.1\|WP_037773873.1\|3417563_3417797_+\|chaplin	unknown	unknown	gnl\|CDD\|367652
NZ_CP011340.1\|WP_037773868.1\|3402427_3403717_+\|glycosyl-hydrolase-family-26	unknown	unknown	gnl\|CDD\|226609
NZ_CP011340.1\|WP_078951250.1\|3399804_3401004_-\|SidA/IucD/PvdA-family-monooxygenase	unknown	unknown	gnl\|CDD\|223566
NZ_CP011340.1\|WP_053556982.1\|3406748_3407519_-\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213023
NZ_CP011340.1\|WP_005312760.1\|3410925_3412410_-\|exopolysaccharide-biosynthesis-polyprenyl-glycosylphosphotransferase	unknown	unknown	gnl\|CDD\|274398
NZ_CP011340.1\|WP_005312774.1\|3416065_3416707_-\|vitamin-K-epoxide-reductase-family-protein	unknown	unknown	gnl\|CDD\|240605
NZ_CP011340.1\|WP_005312781.1\|3419076_3420288_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|181738
NZ_CP011340.1\|WP_005312769.1\|3415083_3415380_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_037773870.1\|3412406_3413588_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340837
NZ_CP011340.1\|WP_005312742.1\|3403784_3404936_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379214
NZ_CP011340.1\|WP_037773872.1\|3413629_3414730_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_159039475.1\|3399512_3399779_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005312729.1\|3398167_3398668_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005312745.1\|3404932_3405598_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|130079

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_053556981.1\|3405594_3406752_-\|glycosyltransferase	gnl\|CDD\|340836	cd03807, GT4_WbnK-like, Shigella dysenteriae WbnK and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.	3.06683e-88
NZ_CP011340.1\|WP_037773873.1\|3417563_3417797_+\|chaplin	gnl\|CDD\|367652	pfam03777, DUF320, Small secreted domain (DUF320). Small domain found in a family of secreted streptomyces proteins. It occurs singly or as a pair. Many of the domains have two cysteines that may form a disulphide bridge.	2.78493e-20
NZ_CP011340.1\|WP_037773868.1\|3402427_3403717_+\|glycosyl-hydrolase-family-26	gnl\|CDD\|226609	COG4124, ManB, Beta-mannanase [Carbohydrate transport and metabolism].	6.85339e-06
NZ_CP011340.1\|WP_078951357.1\|3407508_3409197_-\|virulence-factor-MviN	gnl\|CDD\|240528	cd13123, MATE_MurJ_like, MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	2.67492e-69
NZ_CP011340.1\|WP_053556982.1\|3406748_3407519_-\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213023	cd10918, CE4_NodB_like_5s_6s, Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, hemin storage system HmsF protein in gram-negative species, intercellular adhesion proteins IcaB, and many uncharacterized prokaryotic polysaccharide deacetylases. It also includes a putative polysaccharide deacetylase YxkH encoded by the Bacillus subtilis yxkH gene, which is one of six polysaccharide deacetylase gene homologs present in the Bacillus subtilis genome. Sequence comparison shows all family members contain a conserved domain similar to the catalytic NodB homology domain of rhizobial NodB-like proteins, which consists of a deformed (beta/alpha)8 barrel fold with 6 or 7 strands. However, in this family, most proteins have 5 strands and some have 6 strands. Moreover, long insertions are found in many family members, whose function remains unknown.	1.50807e-50
NZ_CP011340.1\|WP_005312760.1\|3410925_3412410_-\|exopolysaccharide-biosynthesis-polyprenyl-glycosylphosphotransferase	gnl\|CDD\|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	1.41386e-107
NZ_CP011340.1\|WP_005312774.1\|3416065_3416707_-\|vitamin-K-epoxide-reductase-family-protein	gnl\|CDD\|240605	cd12922, VKOR_5, Vitamin K epoxide reductase family in bacteria. This family includes vitamin K epoxide reductase (VKOR) mostly present in actinobacteria. VKOR (also named VKORC1) is an integral membrane protein that catalyzes the reduction of vitamin K 2,3-epoxide and vitamin K to vitamin K hydroquinone, an essential co-factor subsequently used in the gamma-carboxylation of glutamic acid residues in blood coagulation enzymes. All homologs of VKOR contain an active site CXXC motif, which is switched between reduced and disulfide-bonded states during the reaction cycle. In some bacterial homologs, the VKOR domain is fused with domains of the thioredoxin family of oxidoreductases which may function as redox partners in initiating the reduction cascade.	1.52677e-61
NZ_CP011340.1\|WP_037773875.1\|3417881_3418715_-\|putative-protein-N(5)-glutamine-methyltransferase	gnl\|CDD\|274733	TIGR03704, PrmC_rel_meth, putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific. This protein family is closely related to two different families of protein-(glutamine-N5) methyltransferase. The first is PrmB, which modifies ribosomal protein L3 in some bacteria. The second is PrmC (HemK), which modifies peptide chain release factors 1 and 2 in most bacteria and also in eukaryotes. The glutamine side chain-binding motif NPPY shared by PrmB and PrmC is N[VAT]PY in this family. The protein substrate is unknown. [Protein synthesis, Ribosomal proteins: synthesis and modification].	2.97863e-121
NZ_CP011340.1\|WP_037773870.1\|3412406_3413588_-\|glycosyltransferase	gnl\|CDD\|340837	cd03808, GT4_CapM-like, capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.	6.26631e-70
NZ_CP011340.1\|WP_005312742.1\|3403784_3404936_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379214	pfam13480, Acetyltransf_6, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions.	7.97067e-14
NZ_CP011340.1\|WP_078951250.1\|3399804_3401004_-\|SidA/IucD/PvdA-family-monooxygenase	gnl\|CDD\|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	4.41947e-15
NZ_CP011340.1\|WP_005312781.1\|3419076_3420288_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|181738	PRK09265, PRK09265, aminotransferase AlaT; Validated.	0
NZ_CP011340.1\|WP_005312745.1\|3404932_3405598_-\|hypothetical-protein	gnl\|CDD\|130079	TIGR01006, Capsular_polysaccharide_biosynthesis_protein_CapA, polysaccharide export protein, MPA1 family, Gram-positive type. This family contains members from Low GC Gram-positive bacteria; they are proposed to have a function in the export of complex polysaccharides. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	1.59819e-08

>NZ_CP011340.1|WP_078951357.1|3407508_3409197_-|virulence-factor-MviN
MTAAGEPRAAARQAERTADGPFPRPAAPARGRHARRGGRTGGAGRGTPPALGRFLFRAAAVTAGLTAAGAVLGLVRDQTIAHIFGAGIESDAFLIAWTVPEMASTLLIEDAMALLLVPAFSHALARREAGRRITDPVGELVSATFPRLFALLTCAAGLLLIGAPLVVRVLAPGFGDLGLAVDCTRLTALTVLTFGVTGYFSAALRAHGSFLRPASVYVAYNAGIIATTLALHSVWGVRAAAAGVAFGSLLMVAVQLPAFARRTTLRPLVRRPRAKAPLLGAAVLAPVVLFAVGRQSQVLVERFLAAPLPAGAISHLNYAQKVAQMPMVLSLMVCTVTFPVVAKAMAEGDRDRARRRVEQDLAMAGATVLLGTALVVGYAPQIIEVLFQRGAFDARDTATTATVMRVYAAGLLGHCLVGALCRPFFSAGRATWFPAGAMAVGLAVTVVAGAVAVGTFGVNGIAAANAAGISTTALLLLCGLGSRGVAIQVRSVGGRIGRLTVAAAAATAAGLLAAPLTGGPLQSLAAGCLLTPAVFLLTARALRAPEAVHLLGLARRRLLHDH
>NZ_CP011340.1|WP_053556982.1|3406748_3407519_-|polysaccharide-deacetylase-family-protein
MTTDTAAPAAAPALDQPWILMYHTVADPTDDPYGIAVAPDRLELQLRWLRARGLRGVGVADLLRARTAGDAAGLVGLTFDDGYADFVETALPILARYDCTATVFVLPGRLGGTNEWDAEGPRRALLTGRQIRAAAEAGTEIASHGLFHHRLPGCPDDVLLEETVRSRELLCELTGTAPAGFCYPYGTFDRRAADAVRRAGYSYACAIAPGAEAGPYALPRTHISQADRGARLWAKRLRHRARRLPALGPVHLGGAG
>NZ_CP011340.1|WP_053556981.1|3405594_3406752_-|glycosyltransferase
MRVLHIITGLGVGGAEQQLRLLLRHLPAECDVVTLTNPGPVADGLRADGVSVTHLGMRGNTDLTALPRLTGFVRRGRYDLVHTHLYRACVYGRIAARLAGVRAAVATEHSLGGREIEGRPLTRGTRALYLTTERLGAATVAVSPTVAGRLRDWGVPGPRIHVVPNGIDAARFRFDASGRRATRRRLGVPADAYVVGGVGRLVPGKRFDVLVEAVAAVPGVRLLLAGDGPEREALHALAVRLRAADRIRLLGECDADGVAALLSAADLFVSASREEAFGLAVVEALAAGLPVLHSTCPAVDDLPPDDAPGATRLRDGGVRELTDALRARTTAGPRRLPPPRAVGRYDIARGSRLLMDVYAHALDTARPDRDRPEHFHPYPTRRALP
>NZ_CP011340.1|WP_005312745.1|3404932_3405598_-|hypothetical-protein
MTETPEQEPAARGRFRRLAKITLPVWWPLPVCALLGTACGASYGLLKAPEYASTSYVVAVPAKDSDPAAALGFAQAYGRIATSDSTLAYARVAAGVPARELRDRVETETSPDSPMIAITGTSTDPDQAADIANAVTDAIFVSSNQVSKNTGVSLTLFSQAVSPDEPVSPSLPLATAVGGCAGGLLGGLALLVGPRRRAGLTTAGVPAPAHPSEPAGERELV
>NZ_CP011340.1|WP_005312742.1|3403784_3404936_-|GNAT-family-N-acetyltransferase
MTPGGGRISVTLCRDPEAFAALAPEWNRLHDTCPTATPFQSHAWLHSWWRSYGTDGRLRVVLVRRDGRLIGAAPLTLTHGPMPLLVPMGGRISDHCDVLVDGGEVRTAVGALERGLRRAARHAVIDLREVRPGAAAERLYESWKGARARLPDSVCMELPAAPVEELVKRMTSARAQRVRAKLRKIDALKIEAQPVPEAEIADAVTHLLRLHELQWHGRGVNPEHLRPRFAAHLVRATREMARRGEAALTEYRMDGEVVAAALTLRSRNMAGGYLYGADPALRDRKADVATMLLRHDAQQAVDDGQGVLSLLRGAESYKSHWRPETVTNQRLLLAPASLEPLLRLHETRARLRERAVVTVRERLPAAREWRDRLNSRRAASARR
>NZ_CP011340.1|WP_037773868.1|3402427_3403717_+|glycosyl-hydrolase-family-26
MPQRRRLIGTCIGTVTAGLLVSSTVSGIWTAGAAPNADDGPDSPRKPPVAVGAYLHYGPPGIQRMAELSRWLGGRELKVAHTYLPGDRWANIEGRPEFLRPWADWRRGAEDRMFVLNVPMLERSEARLPDFAVRGLLAAGAQGSFDKHFRTLATRLVEAGVPDTVIVLGWEMNGTTYTHRCAPDPEAWKAYWNRIVTAMRSVPGQKFRFDFAPNRGQDAIPWTECYPGDDVVDIIGMDSYDQPPGGTFDEQVNAPYGLRKQVEFAAAHNKAISYPEWGLFRNGDNPEYMRRMLEWIDRHKPLYQTITDYCPHGVWQCQDNPQSSKVFRSKLFAKPGPAEPAPAVPSPAEPAPVEPGPVEPSPAGPSPAQPVPPAGTDPGLPLPSPLPDDVVTNPVDWCVPMDLGDWVGQWIEDRQFCVEFPWPEGQPGF
>NZ_CP011340.1|WP_078951250.1|3399804_3401004_-|SidA/IucD/PvdA-family-monooxygenase
MYDLAVIGAGPYGLSVAAHAAAAGMNLRVFGRTMESWRDHMPEGMFLKSEPWASDLSDPGAKYTLADYAAVRGFEAAHGRPLPIADFAGYGMWFAEHAAPPVEERTVTRVVPSGRCFRVETSDGDGIEARTVALAVGIMPFRRMPEPLAALPPALCSHSSGHLDPSAFGDLDVTVVGAGQAALETATLLAEHGARPQLVARADRIRWNTVPLPRQRGRLSTLRTPLSGLGSGWTTWAWSRLPGAVGRLPAGPRERLTAGSLGPAGAWWLRDRYEQRVPELLGHSLRSASVRDDGRVRLELNAPGGGTRSLDTGHVVAATGFVPDLDRLGLLDPGLRQALRRAGTGRAPALTPRFESSCPGLFFAGLLTAPTFGPAMRFVYGTGFTADRLVAGVRRRLRR
>NZ_CP011340.1|WP_159039475.1|3399512_3399779_+|hypothetical-protein
MARITAPARWQRVQTSTDPTAAPTGNSPIYDQLAREWTAAGRTMPGRPDGEWTRLSLFPPPSPVPEEPAARPASPRSRRGWLYDRHPA
>NZ_CP011340.1|WP_005312732.1|3398782_3399301_-|hypothetical-protein
MRHKATVLVPALLLGLTACQSTGGSGREPAPGASAGAPVTATGIGDTADIGGARFGEHLRVLLRGFVDPAVATGTAPRPAAGHRWVGVELNLANVGGTAHESPLGRTWVVDDRGERHPAVRSGELTTGFPLKVRTLPVGEHADGWLVFEVPFGSRAVGLDCTVGGERRSWRL
>NZ_CP011340.1|WP_005312729.1|3398167_3398668_-|hypothetical-protein
MTTANTPRSAVNRSRLGTLSLLAWTGDPAQGHDTPYLLTYSLGDGVDGPAAGEEAALAMIAELGLTVGDEMHDHTHDGSHPIQLLVEGGQAVVNMPYLKAQCPAPPEWLAAADRRGHVHFMIASRPWPEGRPGEPVSDEAFQSFLGDETTLVSSAHVLLPVSRLRG
>NZ_CP011340.1|WP_005312760.1|3410925_3412410_-|exopolysaccharide-biosynthesis-polyprenyl-glycosylphosphotransferase
MTTESAPAPHSTRATTARRPAPSLHAPRRAAAGRPPVRSHRLSARRDRPTALVVADATAAVVTLALAPAVLWPTADLPAVSVVPLVTFQGVLHAWRGLYRHRLSPSALAELPTLLGLAMLPWYALTATFAAQDPHYGVVLAAPALAAGGQALLACAGRAAVHHARRRAAARRPRSALVVGHGPVAQQVTAALYEHPEYGMRPVGQVDPDRLGGPVQATLPVLVRPEDVSRAVIQNAVGHAVFTRPPGTGPESAALLGLFARHDCRVWLVDGTPADRATHRGSPGKDHLWGFPVRPLDTARRPFALAGKRAMDVCLAAIALVAAAPVLAVCALAVRLSDGPGIIFRQERIGLDGRPFVLLKFRTISPVDEHESATRWSVACDRRMSVTGSLLRRTSLDELPQLWNVLRGDMSLVGPRPERPYFVAKFSHVHPGYQARHRMPVGITGLAQIHGLRGDTSIEERARFDNHYIDTWSLWQDVCILARTAASVLRLGGS
>NZ_CP011340.1|WP_037773870.1|3412406_3413588_-|glycosyltransferase
MLQRNWTEKSRMTVFHLVQPVEGGVARVVTDLVDAQVREGIRAVVACPPQGPLPRLAAQAGAQVHPWPAGREPGPRLAAEVRAVTRLIRTGAPHIVHAHSAKAGLAGRLAVRGRVPTVFQPHAWSFDAVRGRSAELALRWERHGSRWSTRTLCVSESERRAGEEAGIRARWSVIRNGIDLTYFTPRGEHGREEARARLPELDGTPAWAPLVVCVGRLCRQKGQDVLLRAWTEVARAVPGARLVLVGEGPDREALRQGAPPGVIFAGDRADTRPWLHAADLAVLPSRWEGMALAPLEAMACGLPVVVTDVSGARESLPPGQEPYALVPPEDPSTLAAALVRLLSDPALRQDLGRRAEEHTRATSDVRRTAAAVLRLYQELLSPHRSLTRERSER
>NZ_CP011340.1|WP_037773872.1|3413629_3414730_-|hypothetical-protein
MPESPGIAARGVLGALLCTAFSAAPLTAAAAPAPTPPEASGIPFTQRYHSVHRGGIVRAANSAITCRSPKSKDAASCSSLQQGAQGANGDYDMFYVDLDDDPNTYNSSRARLSLPADSRVRYARLYWGGNLRVGEQKPPKDNGRVLIAEPGGDYKEVLADTQVAHRDADGSDSYQASADITPLVRSSGSGHWTVAQINVAMGHSKAGAWGGWTMVVAYEKDTDPLRELVLWDGFESVRPGRAQHSVTMTGLRIGPRSAGRAGLVAYDGDRGARGDSVRVRADDKGQLLIDDRANPSDDSMNSTIADFGTTVTGRQPAHANTLGYDSDVFDIRPALADGANSLTFRFGAEDNGHFLGALFVQADARR
>NZ_CP011340.1|WP_005312769.1|3415083_3415380_+|hypothetical-protein
MKYSKAAAIIAGSVAALGAASPAFAAGSAGMPPMSLNGGVAELVTALPEMESVEAGSAVNQVADSATELNNVKGDAPEQVLKTAGSLTPMLGGVSLGG
>NZ_CP011340.1|WP_005312772.1|3415587_3415998_+|hypothetical-protein
MLKKVTATAALALSVAAAGASMAPQAMALGNDGGTNSLSGNGATQSYGNSATYGKMSPQLSLVQGSLNKPCVGLPLKANAGSLIGGIPVAVQDIPILSAPQNQQCVENSTQAKGDEPLSHILNDIPILSGNGSAID
>NZ_CP011340.1|WP_005312774.1|3416065_3416707_-|vitamin-K-epoxide-reductase-family-protein
MTILATGPVSAEEKGRRRAVKENVGGGRALAWLLVVTGAAGLLAAWVITIDKIKLAEDPGFTPGCSLNPVVSCGSVMESDQATVFGFPNPMLGLATYSVVIGVGMALLAGARFGRAYWLGLNAGCAFGVGFCTWLQYQSLYEINALCLWCSLAWVATIFMFWSVTAHNVRHRLLPAPAWLRGFLDEFGWVPPVLHTGVIGMLILTRWWDFWTS
>NZ_CP011340.1|WP_005312776.1|3416865_3417276_+|hypothetical-protein
MIKKILTTAMVTASMAGAGAMMAPQALALGNDGGTNSASGNFASQEYGNSATHGDMSPQMSLIQGSLNKPCIGLPAKANVGSVVGLIPIAVQDVPILSAPQNQQCVENSTQAKGDEPLSHILSDIPVLSGNGSAVD
>NZ_CP011340.1|WP_037773873.1|3417563_3417797_+|chaplin
MKHMKAAAVVAGIIMAVGSAAPAMADSGAEGIAAHSPGLLSGNVIQIPVHVPINACGNTINVIGLLNPAAGNACANV
>NZ_CP011340.1|WP_037773875.1|3417881_3418715_-|putative-protein-N(5)-glutamine-methyltransferase
MSVSELYPSPSSVSSVVTALRSAGCVFAEDEADLLISAARDPHELAAMVERRIAGLPLEHVLGWAEFCGVRVAVDPGVFVPRRRSEFLVGRAIALAPPRPVVVDLCCGSGALGAAVLRAVGAGELHAADIESAAVRCALRNVGPVGGRVHQGDLYDPLPAGLAGRVDVLIANAPYVPTGEIGLLPPEARDFEPLVALDGGPDGLGIQRRVTARAGRWLAPGGSLLIETSERQAPSTVAAFTRHGLQAEVAVCEDLDATVVIGKRPAHAAGADGSLAR
>NZ_CP011340.1|WP_005312781.1|3419076_3420288_+|pyridoxal-phosphate-dependent-aminotransferase
MQVIQSTKLANVCYEIRGPVLEEAMRLEAAGHRILKLNTGNPAAFGFECPPEILEDILRNLSTAHGYGDAKGLLSARRAVMQHYQTKGIELGVEDIYLGNGVSELIQMSMQALLDDGDEVLVPAPDYPLWTASVSLSGGTAVHYRCDEQSDWMPDLADIERKITDRTKAIVIINPNNPTGAVYDDEMLRSLTEIARRHNLVVCSDEIYDRILYDGATHTPTAALAPDLMVLTFNGLSKNYRVAGYRAGWMAVCGPKAHASSYIEGLTILANMRLCANMPSQHAVATALGGRQSIEELVLPGGRILEQRDVAYDLLTQIPGVTCVKPKGALYLFPRLDPKVYKIKDDRQMVLDLLRAEKIMVVHGTGFNWPEPDHFRIVTLPTAKDLADAVTRIGTFLDGYGQP

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Crispr_ID: NZ_CP011340_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_10

3484544-3484666

Orphan

Consensus_repeat	Method
GGGACCGGACCGGGACACGGGTCGGGCGAAGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_10

>merge|NZ_CP011340|10|3484544-3484666|CRISPRCasFinder
GGGACCGGACCGGGACACGGGTCGGGCGAAGCCCCGGCCGGGCAAAGTTCCGGAACGCCGGCCCAAGCAAAGCCCGGTGCCGGACAGCTGGGACCGGACCGGGACACGGGGTCGGGCGAAGCC

>NZ_CP011340|10|9|3484544-3484666|CRISPRCasFinder
GGGACCGGACCGGGACACGGGTCGGGCGAAGCCC	CGGCCGGGCAAAGTTCCGGAACGCCGGCCCAAGCAAAGCCCGGTGCCGGACAGCT
GGGACCGGACCGGGACACGGGGTCGGGCGAAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_037776367.1\|3478649_3479240_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP011340.1\|WP_037773901.1\|3480453_3481893_-\|NAD(P)H-quinone-dehydrogenase	unknown	unknown	gnl\|CDD\|236112
NZ_CP011340.1\|WP_037773907.1\|3492112_3492853_-\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP011340.1\|WP_005312937.1\|3488359_3489796_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143429
NZ_CP011340.1\|WP_078951253.1\|3491228_3491876_+\|uridine-kinase	unknown	unknown	gnl\|CDD\|223645
NZ_CP011340.1\|WP_037773902.1\|3482714_3483545_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NZ_CP011340.1\|WP_005312933.1\|3487400_3488354_+\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|188646
NZ_CP011340.1\|WP_037773904.1\|3490762_3491119_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005312950.1\|3493025_3493712_+\|two-component-system-response-regulator-AfsQ1	unknown	unknown	gnl\|CDD\|223816
NZ_CP011340.1\|WP_005312922.1\|3482128_3482566_+\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|372719
NZ_CP011340.1\|WP_050791718.1\|3475900_3476314_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_037773909.1\|3493743_3495351_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP011340.1\|WP_078951252.1\|3479364_3480288_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP011340.1\|WP_053556991.1\|3473129_3474266_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238868
NZ_CP011340.1\|WP_005312911.1\|3476715_3478467_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|227111
NZ_CP011340.1\|WP_005312941.1\|3489788_3490676_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|365919
NZ_CP011340.1\|WP_050791490.1\|3475261_3475888_+\|septum-formation-inhibitor-Maf	unknown	unknown	gnl\|CDD\|178901
NZ_CP011340.1\|WP_005312927.1\|3484859_3486515_+\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NZ_CP011340.1\|WP_005312930.1\|3486625_3487261_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|371225
NZ_CP011340.1\|WP_037773899.1\|3474341_3474962_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_037776367.1\|3478649_3479240_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.23433e-09
NZ_CP011340.1\|WP_037773901.1\|3480453_3481893_-\|NAD(P)H-quinone-dehydrogenase	gnl\|CDD\|236112	PRK07845, PRK07845, flavoprotein disulfide reductase; Reviewed.	0
NZ_CP011340.1\|WP_037773907.1\|3492112_3492853_-\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	5.35419e-63
NZ_CP011340.1\|WP_078951253.1\|3491228_3491876_+\|uridine-kinase	gnl\|CDD\|223645	COG0572, Udk, Uridine kinase [Nucleotide transport and metabolism].	5.40026e-17
NZ_CP011340.1\|WP_037773902.1\|3482714_3483545_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	9.33313e-132
NZ_CP011340.1\|WP_005312933.1\|3487400_3488354_+\|deoxyribose-phosphate-aldolase	gnl\|CDD\|188646	cd00959, DeoC, 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. DERA belongs to the class I aldolases and catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2-deoxyribose 5-phosphate. DERA is unique in catalyzing the aldol reaction between two aldehydes, and its broad substrate specificity confers considerable utility as a biocatalyst, offering an environmentally benign alternative to chiral transition metal catalysis of the asymmetric aldol reaction.	3.6733e-78
NZ_CP011340.1\|WP_005312950.1\|3493025_3493712_+\|two-component-system-response-regulator-AfsQ1	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.03565e-81
NZ_CP011340.1\|WP_005312922.1\|3482128_3482566_+\|gamma-glutamylcyclotransferase	gnl\|CDD\|372719	pfam13772, AIG2_2, AIG2-like family. This family is found in bacteria and metazoa.	1.38713e-23
NZ_CP011340.1\|WP_005312937.1\|3488359_3489796_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143429	cd07111, ALDH_F16, Aldehyde dehydrogenase family 16A1-like. Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.	0
NZ_CP011340.1\|WP_037773909.1\|3493743_3495351_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	8.99072e-52
NZ_CP011340.1\|WP_078951252.1\|3479364_3480288_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.6497e-81
NZ_CP011340.1\|WP_053556991.1\|3473129_3474266_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.67143e-85
NZ_CP011340.1\|WP_005312911.1\|3476715_3478467_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP011340.1\|WP_005312941.1\|3489788_3490676_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	3.11544e-46
NZ_CP011340.1\|WP_050791490.1\|3475261_3475888_+\|septum-formation-inhibitor-Maf	gnl\|CDD\|178901	PRK00148, PRK00148, Maf-like protein; Reviewed.	4.78693e-99
NZ_CP011340.1\|WP_005312927.1\|3484859_3486515_+\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_CP011340.1\|WP_005312930.1\|3486625_3487261_-\|PH-domain-containing-protein	gnl\|CDD\|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	0.000128607
NZ_CP011340.1\|WP_037773899.1\|3474341_3474962_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	3.96961e-20

>NZ_CP011340.1|WP_037773902.1|3482714_3483545_+|purine-nucleoside-phosphorylase
MNASVNPDLVGALADPHAAADAAAARLRELTGTETHDVALVMGSGWAPAVDALGTPEAEFPVTELPGFPPPAVEGHGGKVRSYRIGQKRALVFLGRTHFYEGRGVSAVAHGVRTAVAAGCKTVVLTNGCGGLRDGMRPGQPVLISDHINLTAASPIIGANFVDLTDLYSPRLRALCKEVDATLEEGVYVQFPGPHYETPAEINMVRVLGGDLVGMSTVLEAIAAREAGAEVLGISLVTNLAAGLSGEPLNHEEVLQAGRDSAARMGELLTRVLERI
>NZ_CP011340.1|WP_005312922.1|3482128_3482566_+|gamma-glutamylcyclotransferase
MSLYAAYAGNLDARLMTRRAPHSPLRGTGWLNGWRLTFGGEQMGWEGALATIVEAPRSQVFVALYDIAPMDEDSMDRWEGVGLDIYRRMRVRVDTLDGEEPAWVYVLNGYEGGLPSARYLGELADAAESAGAPHDYVMELRKRPC
>NZ_CP011340.1|WP_037773901.1|3480453_3481893_-|NAD(P)H-quinone-dehydrogenase
MTRIVIIGGGPGGYEAALVGAQLGAEVTVVDCDGLGGASVLTDCVPSKTLIATAEVMTTFDSSYEELGIIVADDTPHIEQAARVVGVDLGKVNRRVKRLALAQSHDITASVTRAGARVMRGRGRLDGQQAMDGSRKVVVRAADRTEETLTADAVLIATGGHPREIPDAKPDGERILNWTQVYDLDELPEELIVVGSGVTGAEFAGAYQALGSRVTLVSSRDRVLPGEDPDAAGVLEDVFRRRGMNVMARSRAESAKRVGDRVEVTLSDGRVITGSHCLMAVGAIPNTAGMGLEEAGVRLKDSGHIWTDKVSRTSAPGVYAAGDVTGIFALASVAAMQGRIAMYHFLGDAVAPLNLKTVSSNVFTDPEIATVGYSQADVDAGKIDARVVKLPLLRNPRAKMQGIRDGFVKIFCRPGTGIVVGGVVVSPRASELIHPISIAVDNNLTVEQIANAFTVYPSLSGSIAEVARQLHTRKTAGEG
>NZ_CP011340.1|WP_078951252.1|3479364_3480288_-|DeoR/GlpR-transcriptional-regulator
MFAAERRQLILEMVRANGAVSLRELARVVQTSEVTVRRDVRALEAEGLLDRRHGGAVLPGGFTRESGFPQKSLSATAEKTAIADLAAALVEEGEAIVVGAGTTTQELARRLARVPGLTVVTNSLLVAQALAHANRVEVVMTGGTLRGSNYALVGSGAEQSLQGLRVSRAFLSGSGLTAERGLSTSNMLSASVDRALVQAASEVVVLADHTKLGTDTMFQTVPTDVITRLVTDEPPVHDDRAATELQALADQGVQIAVAGAGAAPAPRPEVPLPGQRRTRAGLRSATGALAPEPLPDRSARVADLRRR
>NZ_CP011340.1|WP_037776367.1|3478649_3479240_+|TetR/AcrR-family-transcriptional-regulator
MLGGVTDTRTKRADARRNYDRLLTEARAAFAERGTDASLEEIARSAGVGIGTLYRHFPNRHAMMNAVFQESLAALLERSRELAGAEQPCTALVEWLRALITHAGEYRGLARALLSASHDRNSALSACSVPLRDAGERLLSRAQETGSVRADVSIDDLMQLTNAIALAAEQDPKDPELADRLLTLTLRGLRSENRPC
>NZ_CP011340.1|WP_005312911.1|3476715_3478467_+|ATP-grasp-domain-containing-protein
MRKVLIANRGEIAVRVARACRDAGIASVAVYADPDRDALHVRAADEAFALGGDTPAASYLDMAKVLQAAADSGADAIHPGYGFLSENAEFAQAVIDAGLTWIGPPPQAIRDLGDKVAARHIAQRAGAPLVAGTPDPVSGADEVVAFAKEHGLPIAIKAAFGGGGRGLKVARTLEEVPELYDSAVREAVAAFGRGECFVERYLDKPRHVETQCLADTHGNVVVVSTRDCSLQRRHQKLVEEAPAPFLSEAQNAELYRASKAILKEAGYVGAGTVEFLVGTDGTISFLEVNTRLQVEHPVTEEVTGIDLVREMFRIADGEELGYDDPAVRGHSFEFRINGEDPGRGFLPAPGTVTAFNAPTGPGVRLDAGVESGSVIGPAWDSLLAKLIVTGATREQALQRAARALAEFEVEGMATAIPFHRAVVADPAFTADPFRVHTRWIETEFVNDIKPFTVPGDTEEDEAGRETIVVEVGGKRLEVSLPSSLGMTLARTGLAAGAKPKRRAAKKSSSAASGDTLASPMQGTIVKVAVEEGQEVKEGDLIVVLEAMKMEQPLNAHRSGTVKGLAAEVGASLTSGATICEIKD
>NZ_CP011340.1|WP_050791718.1|3475900_3476314_-|hypothetical-protein
MEAVGIVVLNGVMATFVGAQRMSLDGMDPDVMVTATWGLGIGSGLFLALCGVLLLVAGIRDRAPGRFARIALITLAVVHGVLGAVAVGLVGWSAFVFLMVVLGLLVASLIVYGNDRSPAGPAEGDDQAAPVSGPAPA
>NZ_CP011340.1|WP_050791490.1|3475261_3475888_+|septum-formation-inhibitor-Maf
MAPMTSPSPHRTRLVLASASPARLNLLRQAGLAPDVIVSGVDEDALTAPTPAELALVLAEAKAAAVAARPEAAGALLIGCDSVLELDGEALGKPADAEEATARWKAMRGRAGVLRTGHCVIDTVTGRRASATASTTVRFGEPTDAEIAAYVASGEPLYVAGAFTLDGRSAPFIDSIEGDPGNVIGLSLPLLRRLLAELGFSITDLWTA
>NZ_CP011340.1|WP_037773899.1|3474341_3474962_+|TetR/AcrR-family-transcriptional-regulator
MEQETRLDATPGTVRPGGRTAKVRAAVLAATQEALVDGGFHALTPDRVAAVAGVGKTTVYRRWRSSAGLVADLLRDMAEQSLPAADTGSLEGDLRANAALVRDTLTDPRMGPVFAAVIAAAACDEECAKALHGFYATRLAEWTPAVERGLSRGEIPAGTDPLDVLRAVSAPLYYRFAVSREPLTADVAQRAAAAALAAARAGAFVV
>NZ_CP011340.1|WP_053556991.1|3473129_3474266_-|SGNH/GDSL-hydrolase-family-protein
MSEWTAAWAASPQMPSTGFTPNWSQEGFSDGTVRQIVRVTAGGERLRIRLSNAYGTSPLHLTGATVARSAGGAAIEEGSVRELTFGGARSAVVPARAELRSDPADLAVERLGSVTVTLYFAGTTGPVTFHSQAWTDSYRAGGDRRADLSGAAFTDVTASWYHLAGVEVAAGRTDGIVLFGDSVTDGFGSTPGADRRWSDALAELTGRPVLNAGIGGNLLLNDSAWYGERGTARFRRDALSQPGVSTVVVLEGLNDIGFSEAPDEPTYKPAPVVGSAEVVAGHRELIRQARAAGVRIVGATLLPLAGSDHWGTHSARVVPEVNHWIRTGGEYDAVVDFDRALADPADPARLHPAYDFGDHLHPGDKGYQVMAELLADVL
>NZ_CP011340.1|WP_005312927.1|3484859_3486515_+|phospho-sugar-mutase
MQQEQDLIARAEAWLAEDPDSETREELARLIEARDLGELADRFGGTLQFGTAGLRGELGAGPMRMNRAVVIRAAAGLAAYLKSKGQTDGPVVVGYDARYKSADFARDTAAVMVAAGLRAAVLPRPLPTPVLAFAIRHLGAVAGVEVTASHNPPRDNGYKVYLGDGSQIVPPADAEIAAEIDAIRALADVPRADEGWETLGDEVLDAYLARTDAVLTAGSPRTAQVVYTAMHGVGKDVVTAAFARAGFPDPVLVAEQAEPDPAFPTVAFPNPEEPGAMDLAFETARRAGPDVVIANDPDADRCAVAVPDDTADGGWRMLRGDEVGALLAEHLVHKGATGVFAESIVSSSLLGRIAAAAGVGYEETLTGFKWIARVEGLRYGYEEALGYCVDPEGVRDKDGITAALLVAELVSELKEQGRTLGDLLDDLAVEHGLHATDQLSVRVKDLGIIANAMRALREQPPAALAGLRVTAAEDLAVGTDRLPPTDGLRYYLDGEFKARVIVRPSGTEPKLKCYLEVVVPVADASALASARARASQVLDGIKRDLSAAAGI
>NZ_CP011340.1|WP_005312930.1|3486625_3487261_-|PH-domain-containing-protein
MTSPQQPEPSTDSDRVFRSPAGMAGGAVLLGLIAWIVVDAVVRGEGRTPWLALAGALLAVPVVVAFTFRPAVFAGEDRIRIRNPFRTIVLPWGSVADVRASYSSEIFTQDGSKYQLWAIPVSLRKRKAAARRQAQAAYDDPHGTTSVHADVSDAKSRIAPADQTIADLRELAERRSSAAEAQGAPQIRWAYEVLAPAVAGAVLLAVLLATG
>NZ_CP011340.1|WP_005312933.1|3487400_3488354_+|deoxyribose-phosphate-aldolase
MTMPTTAPAFADVTASDSTLRRFLHGLPGVDAVGLEGRAASLGTRSIKTTAKAYAIDLAISMIDLTTLEGADTPGKVRALAAKAVNPDPTDRTTPTTAAVCVYPDMVATAKEALKGSQVKVASVATAFPAGRAALPVKIADVRDAVAAGADEIDMVIDRGAFLAGDYMKVYEEILAVKEASGSARLKVIFETGELSTYDNIRRASWLGMIAGADFIKTSTGKVAVNATPANTLLMLQAVRDFKEQTGVQVGVKPAGGIRTSKDAIKFLVLVNETAGEDWLDSHWFRFGASSLLNDLLMQRQKLATGRYSGPDYVTVD
>NZ_CP011340.1|WP_005312937.1|3488359_3489796_+|aldehyde-dehydrogenase-family-protein
MASVFEYAPAPESRSIVDIAPSYGLFIDGEFSDAADGKVFKTVSPSSEEVLAEVARAGAEDVDRAVKAARKAFGKWSALPGAERAKYLFRIARIIQERSRELAVLETLDNGKPIKETRDADLPLVAAHFFYYAGWADKLDHAGYGANPRPLGVAGQVIPWNFPLLMLAWKIAPALATGNTVVLKPAETTPLSALFFADICRQAGLPNGVVNILPGYGDTGAALVEHPDVNKVAFTGSTAVGKAIARQVAGTRKKVTLELGGKGANIVFDDAPIDQAVEGIVNGIFFNQGQVCCAGSRLLVQESIQDELLDSLKRRLSTLRLGDPLDKNTDIGAINSEEQLSRITTLVEAGEAEGAERWSPACELPSSGYWFAPTLFTNVTQAHTIARDEIFGPVLSVLTFRTPDEAVAKANNSQYGLSAGIWTEKGSRILAVANKLRAGVVWANTFNKFDPTSPFGGYKESGFGREGGRHGLEAYLDV
>NZ_CP011340.1|WP_005312941.1|3489788_3490676_+|aldehyde-dehydrogenase-family-protein
MSDGRLSVFKTYKLYVGGKFPRSESGRVYEVTDSKGKWLANVPLSSRKDARDAVVAARKAFGGWSGATAYNRGQILYRIAEMLEGRKDQFVREVAQSEGLSRSKAADVVDAAIDRWVWYAGWTDKIAQVVGGANPVAGPFFNLSTPEPTGVVTIVAPQESSFLGLVSVVAPVIAAGNTVVVVASERAPLPALSLGEVLATSDLPGGVVNVLSGRTAEIAAPLAAHQDVNGIDLTGADEVLAKELEVAAADNLKRVFRPQAVDYSADPGTHRLTAFLETKTVWHPTGSLGASGSAY
>NZ_CP011340.1|WP_037773904.1|3490762_3491119_-|hypothetical-protein
MARHAASKNNRRTLLRAGLTVAAAGAALGAGGATANAAVPVGTATGLVTNSVSGVGELKSLQLHPLANTGVDPLDNAVGTQVADFKPVSTAMATDNITKGQALEDLPVAGPVAASLLP
>NZ_CP011340.1|WP_078951253.1|3491228_3491876_+|uridine-kinase
MSPVSSQPIPTRVVLLAGPSGSGKSSLAARTGLPVLRLDDFYKEANDPTLPLVTGSTDIDWDSPSSWDADAALAAIAELCRSGRATVPVYDIATSSRVDVETLDTARTPLFVAEGIFAADLVGRCQEMGVLADALCLRGRPSTTFRRRLARDLREGRKSLPMLLRRGWRLMRAERGIVARQAGLGAHPCGKAEALGRVAAAAAGHCRLPVARQPA
>NZ_CP011340.1|WP_037773907.1|3492112_3492853_-|SigE-family-RNA-polymerase-sigma-factor
MNALHSTTSSAVVTRLHDVARSTEKSGAVNGRGCVRGAGRQHKPPFMAVVDAPTGGSGAAYGEPKPAGERASCSEAEFTAYVQERRASLYATAYHLTGDRYEAEDLLQSALFSTYRAWERISDKAAVGGYLRRTMTNLHISAWRRRKLNEYPTEELPETAGDTDAMRGTELRAVLWQALARLPELQRTMLVLRYYEGRTDPEIAEILDISVGTVKSSIWRSLRRLREDEVLSFGRDEEESFGELVA
>NZ_CP011340.1|WP_005312950.1|3493025_3493712_+|two-component-system-response-regulator-AfsQ1
MAPVPFLLLIEDDDAIRTALELSLSRQGHRVATAATGEDGLKLLREQRPDLIVLDVMLPGIDGFEVCRRIRRTDQLPIILLTARSDDIDVVVGLESGADDYVVKPVQGRVLDARIRAVLRRGERESTDSATFGSLVIDRSAMTVTKNGEDLQLTPTELRLLLELSRRPGQALSRQQLLRLVWEHDYLGDSRLVDACVQRLRAKVEDVPSSPTLIRTVRGVGYRLDVPQ
>NZ_CP011340.1|WP_037773909.1|3493743_3495351_+|HAMP-domain-containing-histidine-kinase
MSDGTNGGGAPRRGILTGIRLTSLRLRLVVVFALVALTAAVSASGIAYWLNREAVLTRTQDAALEDFRQDMQNRAAALPLRPTQDELQRVAEQMGNDGNGYSVLLIGERAEGKPIVGASDPDEFTKKDVPQSLQDAVNERQEIGAGNTVPYHLYWQRTERGGTPYLVGGTRIVGGGPTGYLFKSLDQERQDLNSLAWSLGIATLLALVGSALLAQAAATTVLRPVHRLGEAARQLGEGKLDTRLRVSGTDELAELARTFNKTAASLEKKVADMSARDESSRRFVADMSHELRTPLTALTAVTEVLEDEADSLDPMIAPAVNLVVSETRRLYDLVENLMEVTRFDAGTARLVMDTVDVADQVTACIDARAWLDAVELDAERGIMARLDPRRLDVILANLIGNALKHGGSPVRVSVRPVDGELVIEVRDHGPGIPEEVLPHVFDRFYKASASRPRSEGSGLGLSIAMENAHIHGGDITAANSPEGGAVFVLTLPRDGSSLQDCEAVGTGDADAPGAAGAGGRTAADDSRPQGEGDAL

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Crispr_ID: NZ_CP011340_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_11

4098705-4098773

Unclear

Consensus_repeat	Method
CGCGGGGCCGAACCTCACCGCGG	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP011340_11

>merge|NZ_CP011340|11|4098705-4098773|CRISPRCasFinder
CGGCGGTCCCCCCGTCACCGCGGCCGTCTCACCACGGACCTCCTGTCGCGGCGCCGGCCCTCAGCGCGG

>NZ_CP011340|11|10|4098705-4098773|CRISPRCasFinder
CGGCGGTCCCCCCGTCACCGCGG	CCGTCTCACCACGGACCTCCTGT
CGCGGCGCCGGCCCTCAGCGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_053557076.1\|4100631_4101219_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_158685170.1\|4084326_4084491_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_050791726.1\|4107802_4108129_-\|flp-pilus-assembly-TadE/G-like-family-protein	unknown	unknown	gnl\|CDD\|274799
NZ_CP011340.1\|WP_037774106.1\|4082065_4083388_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377488
NZ_CP011340.1\|WP_005314342.1\|4098176_4098374_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005314347.1\|4101418_4103824_-\|sodium-translocating-pyrophosphatase	unknown	unknown	gnl\|CDD\|234827
NZ_CP011340.1\|WP_005314338.1\|4091871_4094991_-\|dTMP-kinase	unknown	unknown	gnl\|CDD\|234814
NZ_CP011340.1\|WP_005314340.1\|4095147_4097952_-\|type-I-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|236048
NZ_CP011340.1\|WP_005314329.1\|4085187_4085760_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP011340.1\|WP_005314334.1\|4088833_4090375_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|312032
NZ_CP011340.1\|WP_005314369.1\|4110137_4110974_-\|integral-membrane-protein	unknown	unknown	gnl\|CDD\|227300
NZ_CP011340.1\|WP_005314336.1\|4090479_4091685_-\|DNA-polymerase-III-subunit-delta'	unknown	unknown	gnl\|CDD\|236134
NZ_CP011340.1\|WP_005314349.1\|4104396_4104840_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NZ_CP011340.1\|WP_005314359.1\|4105383_4107867_+\|DEAD/DEAH-box-helicase	cas3	mkCas0139_cas3_CAS-I	gnl\|CDD\|274800
NZ_CP011340.1\|WP_005314366.1\|4109352_4110141_-\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|224975
NZ_CP011340.1\|WP_003967428.1\|4104951_4105305_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP011340.1\|WP_005314331.1\|4085943_4088202_+\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379232
NZ_CP011340.1\|WP_053557075.1\|4098864_4100364_-\|methyltransferase	unknown	unknown	gnl\|CDD\|237872
NZ_CP011340.1\|WP_005314364.1\|4109083_4109284_-\|DUF4244-domain-containing-protein	unknown	unknown	gnl\|CDD\|379429
NZ_CP011340.1\|WP_050791513.1\|4083402_4084236_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_005314334.1\|4088833_4090375_-\|alpha/beta-hydrolase	gnl\|CDD\|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	1.12777e-34
NZ_CP011340.1\|WP_005314359.1\|4105383_4107867_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|274800	TIGR03817, DECH_helic, helicase/secretion neighborhood putative DEAH-box helicase. A conserved gene neighborhood widely spread in the Actinobacteria contains this uncharacterized DEAH-box family helicase encoded convergently towards an operon of genes for protein homologous to type II secretion and pilus formation proteins. The context suggests that this helicase may play a role in conjugal transfer of DNA.	0
NZ_CP011340.1\|WP_050791726.1\|4107802_4108129_-\|flp-pilus-assembly-TadE/G-like-family-protein	gnl\|CDD\|274799	TIGR03816, tadE_like_DECH, helicase/secretion neighborhood TadE-like protein. Members of this small, highly hydrophobic protein family occur in a pilus/secretion-like region that usually is next to an uncharacterized DEAH-box helicase, in Actinobacteria. Members show sequence similarity to the TadE-like family described by pfam07811. The function is unknown. [Unknown function, General].	2.9393e-08
NZ_CP011340.1\|WP_037774106.1\|4082065_4083388_-\|hypothetical-protein	gnl\|CDD\|377488	pfam05222, AlaDh_PNT_N, Alanine dehydrogenase/PNT, N-terminal domain. This family now also contains the lysine 2-oxoglutarate reductases.	6.59618e-26
NZ_CP011340.1\|WP_005314347.1\|4101418_4103824_-\|sodium-translocating-pyrophosphatase	gnl\|CDD\|234827	PRK00733, hppA, membrane-bound proton-translocating pyrophosphatase; Validated.	0
NZ_CP011340.1\|WP_005314338.1\|4091871_4094991_-\|dTMP-kinase	gnl\|CDD\|234814	PRK00698, tmk, thymidylate kinase; Validated.	7.55568e-80
NZ_CP011340.1\|WP_005314340.1\|4095147_4097952_-\|type-I-DNA-topoisomerase	gnl\|CDD\|236048	PRK07561, PRK07561, DNA topoisomerase I subunit omega; Validated.	0
NZ_CP011340.1\|WP_005314329.1\|4085187_4085760_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.71107e-08
NZ_CP011340.1\|WP_003967428.1\|4104951_4105305_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	4.53055e-33
NZ_CP011340.1\|WP_005314369.1\|4110137_4110974_-\|integral-membrane-protein	gnl\|CDD\|227300	COG4965, TadB, Flp pilus assembly protein TadB [Intracellular trafficking and secretion].	2.41693e-14
NZ_CP011340.1\|WP_005314336.1\|4090479_4091685_-\|DNA-polymerase-III-subunit-delta'	gnl\|CDD\|236134	PRK07940, PRK07940, DNA polymerase III subunit delta'; Validated.	0
NZ_CP011340.1\|WP_005314349.1\|4104396_4104840_-\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	3.00704e-27
NZ_CP011340.1\|WP_005314366.1\|4109352_4110141_-\|type-II-secretion-system-F-family-protein	gnl\|CDD\|224975	COG2064, TadC, Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion].	3.18945e-09
NZ_CP011340.1\|WP_005314331.1\|4085943_4088202_+\|VCBS-repeat-containing-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	3.29532e-05
NZ_CP011340.1\|WP_053557075.1\|4098864_4100364_-\|methyltransferase	gnl\|CDD\|237872	PRK14968, PRK14968, putative methyltransferase; Provisional.	4.72773e-19
NZ_CP011340.1\|WP_005314364.1\|4109083_4109284_-\|DUF4244-domain-containing-protein	gnl\|CDD\|379429	pfam14029, DUF4244, Protein of unknown function (DUF4244). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 95 amino acids in length. There is a conserved EYA sequence motif.	4.58642e-20

>NZ_CP011340.1|WP_005314342.1|4098176_4098374_-|hypothetical-protein
MESGPAIFAGTAFALFGAALLLWTGTRALHRRPVAHGVATATGVTFGMLFGAVFLTLAVWCFGRL
>NZ_CP011340.1|WP_005314340.1|4095147_4097952_-|type-I-DNA-topoisomerase
MSPTSETAHGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVPEKYTGEVRRLGVDVEHDFQPIYVVNADKKAQVRKLKEQLAESDELFLATDEDREGEAIAWHLLEVLKPKVPVHRMVFHEITKEAIRDAVANPRELNKRMVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFSTGRAGDPSDPSTLTARLNTVDGQRVAQGRDFGSDGRLKSAQVLHLDEANARSLAAALEGASFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSETAVAAARAQVTQLYGADYLPEKPRVYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFKLYELIWKRTVASQMKDAVGNSVTVKIGGRGSDGRDAEFSASGKTITFHGFMKAYVEGADDPNAELDDRERRLPQVAEGDALSSEEISVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIARGEAQAVPWLRRFYFGEGDAAGAASEAGNGDGDHLGGLKELVTDLGAIDAREISSFPVGNDIKLRVGRYGPYVERGEKEAEGHQRADVPEDLAPDELTVEYAEELLAKPSGDFELGTDPATGHQIIARDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKNMSLDTVTLEDALKLMSLPRVVGTDAEGVEITAQNGRYGPYLKKGTDSRSLENEEQLFSITLEEALAIYAQPKQRGRAAAKPPLKELGTDPVSERPVVVKDGRFGPYVTDGETNATLRTGDSVEDITPERGYELLAEKRAKGPAKKAAKKTPAKKTAAKKTAAKKTTAAKKTTAKKTTAKSAAKKTAASADE
>NZ_CP011340.1|WP_005314338.1|4091871_4094991_-|dTMP-kinase
MTRAEQPAEQQAVMSTASQTASDASGSDALATDSRERAVRSLLRHPPLRRLWNAQVVGGIGDALAVLVLLLLTLQAAVESGSFGSGYRGAAFAVAAVFGARVLSTLLFGAVLLGPMTSLTAPSGPFDRRWTMIGSDGLRLALLVVAPLWLDWTPDNALAILLVTVFLTGVAERFWTVAREGAAPALLPAPPPEGASVRPLPDHLESLRTLWLRTAFAVVPAAAAALLVATLIGNLLGTGVEWFSRHQAALGSYLAAGLFAASVSILYFVELPGSQTPRPRSPLEGLRRPSRGEGPDKGRTGAIPLFVLACASVTAAVASAAAVAVLHAVDLGGGPVTFSLLILALVGGTGAGIRGAGAVLPSLSRRRLLALALAVTGVALLALGLVPDTATGLFLAAVAGVFAGIAANTGHALADQETEDFRRARLATHLQAVVRVVIGLAAVAAPLLAAAIGPHRLAGGDFVFAHGGAAFTLMLVGALLLPVAAIVLAKTDDRSGVPLRRDLRDALRRGADPGQAPATSGFFIAVEGGDGAGKSTQVEALAEWIRAKGHEVVVTREPGATPVGKRLRSILLDVSSAGLSNRAEALLYAADRAEHVDSVIRPALDRGAIVISDRYIDSSVAYQGAGRDLSPTEIARISRWATDGLVPNLTVLLDVSPEAARERFTEAPDRLESEPAEFHQRVRSGFLTLAAADPGRYLVVDAGQEPGSVTTVVRHRLDQLLPLSDAEIKAREEARKAAEEAARRKAEEEAARKAEEERLERERQEQLAKLRAEEEERKRRELEEARQREAERQAEEARQRAEEARRRAEEERQRREAEERARQAEQERLRKQAEEEARLRKEAEERRLEKQRKAEEALLKAEQARRAAEAAAAAAAAASAVETTVTTPVVKPDEVTQEVPVPGGSHDATSVLPKVPDETETTMLPKVPDEAETTMLPPVRDARAADETAVLPPVRDAGPADRVPPGIFRDEHEERGVGGGNERTTELPQVDPSAERPRRRSDWAEETPLDDLPTLADELLGPHEDDENDGGRGRRGRRG
>NZ_CP011340.1|WP_005314336.1|4090479_4091685_-|DNA-polymerase-III-subunit-delta'
MAVWDDVVGQERVQEQLSAAARDADAHVTAHAAGEPVPPASKMTHAWLFTGPPGSGRVTAARAFAAALQCTGPDRALGGTPGCGFCDGCHTALIGTHADVSWIAATGTQILVSDMRDTVRKSFTAPANGRWQVILVEDAERLNERSANAVLKAVEEPAPRTVWLLCAPSVEDVLPTIRSRCRHLTLRTPPVAAVADVLIRRDGVEPDLAATAARATQGHIGRARRLATDERARARRSAVLKMPLRVEDIGGCLRAAQELVDAAADDAKQVAEDTDVKETEELRAALGASEGGRMPRGTAGLMKELEDLQKRRKTRTQRDSLDLALTDLTGFYRDVLALQMGSRVALANEDVRDSLDRIARSSTPESTLRRIEAIVACREALERNVAPLLAVEAMTVALRAG
>NZ_CP011340.1|WP_005314334.1|4088833_4090375_-|alpha/beta-hydrolase
MDTRRLLRTYALPLATVGLLVSGCTTGGPSVSESEAPGTAGRSAPSAALAPYYGQKLDWRECGVPNFECATMKAPLDYAKPEGETIKLAVSRAKATGPGKRLGSLLVNPGGPGGSAVGYLQAYAGIGYPAPVRARYDMVAVDPRGVARSEPVQCLSGPEMDRYTQVDQTPDDAAEADTLEQAYEKFATGCEKRSGKVLPHVSTTEAARDMDIARAVLGDEKLNYVGASYGTFLGATYAELFPDRTGRLVLDGAMDPALPARELNRDQTAGFETAFKSFAADCVKQADCPLGKKSVADATTRLKDFFAKLDASPVPTGQDRELGESLATTGVIAAMYDDGAWPQLRTALAAAQDGDGAPLLAMADSYYEREADGSYANLMFANAAVNCLDLPAAFKTSDAVRAAAPEFEKASPVFGRGFAWAALNCGHWPVPPTGKPHPIEAKGAAPIVVVGTTRDPATPYKWAESLAGQLSSGRLLTYDGDGHTAYGRGSDCVDTAINTYLLEGEAPKDGTRC
>NZ_CP011340.1|WP_005314331.1|4085943_4088202_+|VCBS-repeat-containing-protein
MIHARPARRRLAAAVVTVLAVTAVGASALTVPAIAVPAAEGTTGAAAASTAGVVPFPAKSTIFGATANGYLTSTEVPPMDEGGPTYTAHWVRADGSPATDIAWAARVESTGSGDIVAFGWASGGRLTDMATGTNLRSITFGEDTAYAGAAGKALFTTTLNVDGNRLLHMHTTTSGAVRMTAGLPGDATGVVVKAGTAEHALLTYSTGTGTTAKKYVAMLDLATNAVTETYELPAAAARGDLAVSATHLAWVEYDANHNVTVVAVDRATKNPQRFTVGNAWRSDVEVGLVGDWVTYGTRSGLTDLEVDPLYALTARSLKDGTTTRKLLDHTLTAASAPDGTQVVRGGTVADGEGLYRIAPGADGAAPTASLVASSGESTKVALLSTKIPAVIDLDQNRGRVPLEWTLSRYTATATVTLRHVRTGRTSVAGFIQPENAVVRYDWLGDLNNDSALSESAYNGDYTWEISAKPLNGIGPELKQTGTFKVTRKAAPHDYNDNGSPDLLLRDSAGQLTRADSYYNPWINTGQLSAAEQKVIGSGWNMHNRIEAAGNLAGDATGDIVARDTTGVLWHYLGKGDGTFATRTKIGGGWQIYNRIAAGSDLTGDGRPDLVATDAAGALWLYKATGSTSAPFAARQKIGLSGWQQFDIIEATGNIAGGSAGDLVARDKDGVLWLYQGRGDGTFAGRVKIGGGWNTYKHLVGIGDANRDGRPDLFAYGSTGTYLYKGTGSSTAPFGAREATSLPDAALTHTSVV
>NZ_CP011340.1|WP_005314329.1|4085187_4085760_+|GNAT-family-N-acetyltransferase
MTIEVRPASVFEDVRTLLGPKSPDANVCWCLSYRIPSRLNNELRGPARGAYVAELCRTGPPPGVLAYDGDEPVGWAAVAPRSDTSFARNRKIPHVDDLPVWSLWCIRVRPGHRKQGISHALIAGAVEFARAHGAPAVEAYPLDNGGAKVDLTMAYAGIRKNFERAGFTKAADTTSVLAGHPRILMRLDLR
>NZ_CP011340.1|WP_158685170.1|4084326_4084491_-|hypothetical-protein
MSDERITPPDPGPARSSALEQYEIDVSRIYAHDPDHVYSGSDARGVEDPAMRGL
>NZ_CP011340.1|WP_050791513.1|4083402_4084236_-|hypothetical-protein
MTIEAVSPAMTMREAAVALLAHGNVPGPHVDAEQVARIDRMIARHRLTLDEKLTAAKRQYSAEHYARTTALLPAELISELRAEARRLADLNTRRIDITVPVTGDTPRRLGSLPNSLFQEQSKLFTALYNSVEFRSVLSTVVGTPVLDASFEDEKITGTHQSRAGDTHGWHWGDHEFAFIFIAEAPSIEHGGMLQAVPHTVWDKKNPAVHENLAGGTIRTYHHEAGESYVFKTDTTLHRTVPIQTEGVERIIVNLTLASLKDWLEEKSYETTNAVYTD
>NZ_CP011340.1|WP_037774106.1|4082065_4083388_-|hypothetical-protein
MTTILFAKESDCEENPGGHDLRATLVPQDVRRYVDRGFDVVIQQGLGEGIGYLDRQYELEGARVEPYPSCYGGKDLVVKLKGPSAAEVAQLSYGTTLFSMGHLYCFPERERLLRDKGVRLVGMETVTDPQEPSDGYLAGIAAGSGVDVDALGPEPEVLIDSSAPQEYVNGLLRSLMRYGRKPLRVRYTDTDGPEQSRAAVSGSAVLTAGDGVTDLAPAVGAPYRLGEEDLPAGRDGLLAEERGKPVRAIGQIREVGIGGTKYGLDLFRSRNAGRTPEVLVLGYGNCSMGAFEHLRDRRVEFTVLGRPQTSPEELPGRLASAQLIVNGAETPGQSEYIITRRNAERDVPVGAVVIDLIGGSPALRSPVESFVWTTFLPDIHFEEHGRFFAGLWGWDMYYSMHDTALEYSRRIAKVLTSGDRYAKSLDDFVSDYAYALQLEG
>NZ_CP011340.1|WP_053557075.1|4098864_4100364_-|methyltransferase
MSTTSLPVPDHAPRLREALLLAAFTADGLLDLLGAPAYAALARSETVPALRATRGEGVLETLVRLFLLQRAVPLEGARKALPLEECLTDGWVKQDGDEVRATVDVRPYGGPEGQDWFIVSDLGCAVGGAGGAGGQGEGVVLGVGGASTTLAGITIRTPVGSALDLGTGSGIQALHAAQHATRVTATDLNPRALHFTRLTLALSGAREADLREGSLFEPVGSDTYDLIVSNPPFVISPGARLTYRDGGMGGDDLCRSLVQQAGDRLNDGGHAQFLANWQHVEGEDWQDRLRSWVPPGCDAWIVQREVQDVTQYVELWLRDSGDHSTDPDRYAARYDAWLDEFEARRTKSVGFGWITLRKSGAERPSIVTEEWPHPVEQPLGDTVRAHFARQDYLRERDDAALLADHFVLTEEIMQEQVGMPGAEDPEHVVLRQNRGMRRATKVDTVGAGFAGACDGSLSAGQILDAIAQLLGEDPVLLRDRTPQALRLLIEEGFLEPAPR
>NZ_CP011340.1|WP_053557076.1|4100631_4101219_-|hypothetical-protein
MNKKLAAALSGGAVLVLALSGCGDDSEEKVNAWAKDVCDQAQPQIKKRADAQQAIISTAADGKPADIQAADSKAFADIAAADKALAKAVRDAGVPPVDNGEKLQQDAVKELDATAAAYLDLKKKVDELDPKNQQKFADGLQTVADGLKKIERMDQEALAKLQSGELGKAMAKQPGCQRADTSSPAGGASPSSGKA
>NZ_CP011340.1|WP_005314347.1|4101418_4103824_-|sodium-translocating-pyrophosphatase
MAGLFNPHLIDHPTSLAAAVLTDDNRLIVIVIAAVALAALVVAQLLVRQVLAAGEGTDSMKKIAAAVQEGANAYLARQLRTLGVFAVVVFFLLMLLPADDWAQRAGRSVFFLVGALFSAATGYIGMRLAVRANVRVAAAAREATPAEGEPEKDLTAVSHKAMKIAFRTGGVVGMFTVGLGLLGASCVVLVYAADAPKVLEGFGLGAALIAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAGMAADLFESYAVTLVAALILGMAAFGDAGLAFPLIVPAIGVVTAMIGIFAVAPRRADRSGMTAINRGFFISALISLVLVAVAAFVYLPGSYAELDGVGDAAVRAHDGDPRVLALVAVAIGIVLAALIQQLTGYFTETNRRPVRDIGKSSLTGPATVVLAGISIGLESAVYTALLIGLGVYGAFLLGGTSIMLALFAVALAGTGLLTTVGVIVAMDTFGPVSDNAQGIAEMSGDVTGAGAQVLTDLDAVGNTTKAITKGIAIATAVLAAAALFGSYRDAIATAATDVGEKLGDGAPMNLVMDISQPNNLVGLVLGAAVVFLFSGLAINAVSRSAGAVVYEVRRQFREHPGIMDYTEKPEYGRVVDICTKDALRELTTPGLLAVLTPIAVGFSLGVGALGSFLAGAIGTGTLMAVFLANSGGAWDNAKKLVEDGHHGGKGSEAHSATVIGDTVGDPFKDTAGPAINPLLKVMNLVALLIAPAVIQFSYGDDASAGVRAVVAVLAILIIVGAVYISKRRGIAVGDDSGAAERSAKPTDPAVVS
>NZ_CP011340.1|WP_005314349.1|4104396_4104840_-|ATP-binding-protein
MATVELRFSAQPEHVRTARLVAAAVARRAGVEEAVLDEVRLAVGEACSRAVGLHRSHGITAPVRVVLADEEKIFSIEVGDEVPSAGAGSTAVSGGRGEGAEDFDAEGEDEMGLAVISGLVDDVEVSSTEDGGVIRMSWPAASFAITP
>NZ_CP011340.1|WP_003967428.1|4104951_4105305_-|STAS-domain-containing-protein
MDLSLSTRNVSGPGGDRTVVEVGGEIDVYTAPKLREQLVELVNDGSYHLVVDMEGVDFLDSTGLGVLVGGLKRVRAHEGSLRLVCNQERILKIFRITGLTKVFPIHTTVDEAVAATD
>NZ_CP011340.1|WP_005314359.1|4105383_4107867_+|DEAD/DEAH-box-helicase
MAFNHLPAAMHDALGPLSVTPVTHSVPMAMNHRPSRPPGSVENRPSPSTVLDRLAAGASRAARITHTEHLPPRPGRHAVWPDRIRAEVISAVRDAGIEHPWAHQATAAEHALDGESVVIATGTASGKSLAYLAPVLSTLLDGAEAANGRGTTALYLAPTKALAADQRRSVKELAAPLGNRIRPAVYDGDTPVEEREWVRQYANYVLTNPDMLHRGILPAHPRWSSFLRSLRYVVIDECHTYRGVFGSHVAQVLRRLRRLCARYGANPVFLLASATSAEPAVSAGRLTGLPVHEVADDASPRGELVFALWEPPLTELQGEKGAPVRRTATAETADLLTDLTVQGVRSVAFVRSRRGAELISVIAKERLAEVDRSLPRRVAAYRGGYLPEERRALERALHSGELLGLAATTALELGVDVAGLDAVVIAGYPGTRASLWQQAGRAGRSAEGALAVLVARDDPLDTYLVHHPEALFDRPVESTVLDPDNPYVLAPHLCAAAAELPLTEPDLELFGPGAADLMPQLEAARLLRRRASGWHWTRRERAADLTDIRGGGGRPVQIVESATGRLLGTVDEGAAHTAVHDGAVHLHQGRTYLVERLVLEDSVALVKEAGPPYSTTARDTTSISVLETDVEVPWGDGRLSYGSVEVTNQVVSFLRRRLITGEVLGESKLDLPPRTLRTRAVWWTVTEDQLDAARVNPEQLGGALHAAEHASIGMLPLFATCDRWDIGGVSVPLHPDTLLPTVFVYDGHPGGAGFAERAFHTAREWLTATREAIASCECEAGCPSCIQSPKCGNGNDPLHKRGAVRLLTELLRTAPAAQETPTAPPGP
>NZ_CP011340.1|WP_050791726.1|4107802_4108129_-|flp-pilus-assembly-TadE/G-like-family-protein
MATTVLCAVFAIILAMGQAVVARHRAGAAADLAALAAADNALRGTAEACATAGRVADAQGARIVRCSVAGETADVTALARFGPYAPTVRARAGPSESPEPPALSGAVR
>NZ_CP011340.1|WP_005314364.1|4109083_4109284_-|DUF4244-domain-containing-protein
MWQAMRVRLTALRRRMRTDDGMTTSEYAMGTIAACAFAAVLYKIVTSGTVSGALEAVIGKALDAQF
>NZ_CP011340.1|WP_005314366.1|4109352_4110141_-|type-II-secretion-system-F-family-protein
MNGEAVHRLGTTAAILSALACLVSLAAAKRREGRARTRGAALLRAGPEAPRRRVDLGRWAKPWAAPLGVAVVGWFLIGGATGGAVGLVAAVGVRRWQRGREKRTGAGTPAADARKEAARQLPLAADLMAACISAGASPREAAEAVGESLGGPVGAGLARTAAQLRLGAEPSPAWGCFGEIPGAEPLARCLERADSAGAPAADPVSRLAGRLRAERARAVAGRGRRAQVLITAPVGLCFLPAFLAVGVAPVVIGLAGGLLHGN
>NZ_CP011340.1|WP_005314369.1|4110137_4110974_-|integral-membrane-protein
MCAAALCLVAATWLLTVGQERALRRARLMLAGPGAAVLPPWWSWRGLLPVITFRKEWWCLPAGVAVAVAGESPLPLAAGAVAVPLVRRWLRARERRRDEDRRARGVIGLCGATAGELRAGLQPAQALLFAVGATDVLGDAEARVLAAARFGGDVPEALRSAARQPGAEGLAGVAACWRVAVDGGAGLAAGLDRLEASLRAEMDQREELAAQLAGAWSTIVLLALLPVAGLAMGWALGADPLHVLFHSPAGIACLVIGGLLETAGLCWAGRIVRAGEEA

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Crispr_ID: NZ_CP011340_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_13

4616376-4616459

Orphan

Consensus_repeat	Method
CCGTGTCACCGGGCGGTGCGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_13

>merge|NZ_CP011340|13|4616376-4616459|CRISPRCasFinder
CCGTGTCACCGGGCGGTGCGGGGCGGGAGTGGCGTCCGCCCGCGGAGAAGGGGGCGGCGCCCCGTGTCACCGGGCGGTGCGGGG

>NZ_CP011340|13|12|4616376-4616459|CRISPRCasFinder
CCGTGTCACCGGGCGGTGCGGGG	CGGGAGTGGCGTCCGCCCGCGGAGAAGGGGGCGGCGCC
CCGTGTCACCGGGCGGTGCGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_106428547.1\|4615421_4616168_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP011340.1\|WP_053557136.1\|4613973_4615350_-\|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|379143
NZ_CP011340.1\|WP_037774292.1\|4627103_4628783_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP011340.1\|WP_053557134.1\|4608680_4609871_+\|hemin-transporter	unknown	unknown	gnl\|CDD\|237337
NZ_CP011340.1\|WP_086025651.1\|4611853_4612885_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP011340.1\|WP_053557135.1\|4613013_4613958_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381307
NZ_CP011340.1\|WP_037776596.1\|4628800_4630075_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NZ_CP011340.1\|WP_107082437.1\|4620007_4622158_+\|asparagine-synthase	unknown	unknown	gnl\|CDD\|273676
NZ_CP011340.1\|WP_005315409.1\|4630235_4630805_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP011340.1\|WP_107082436.1\|4610039_4611398_+\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP011340.1\|WP_005315370.1\|4603665_4606704_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379232
NZ_CP011340.1\|WP_053557139.1\|4625500_4626976_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP011340.1\|WP_005315372.1\|4607024_4607198_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005315416.1\|4636697_4637372_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP011340.1\|WP_037776594.1\|4624393_4625176_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP011340.1\|WP_005315420.1\|4637368_4638652_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP011340.1\|WP_078535306.1\|4607282_4607996_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NZ_CP011340.1\|WP_053557138.1\|4622230_4624195_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|214816
NZ_CP011340.1\|WP_086025599.1\|4617811_4619350_-\|sporulation-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005315374.1\|4608154_4608598_+\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|273242

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_106428547.1\|4615421_4616168_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	7.51484e-90
NZ_CP011340.1\|WP_053557136.1\|4613973_4615350_-\|PrsW-family-intramembrane-metalloprotease	gnl\|CDD\|379143	pfam13367, PrsW-protease, Protease prsW family. This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Aflv_1074, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress.	4.54747e-52
NZ_CP011340.1\|WP_037774292.1\|4627103_4628783_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	3.10795e-50
NZ_CP011340.1\|WP_053557134.1\|4608680_4609871_+\|hemin-transporter	gnl\|CDD\|237337	PRK13289, PRK13289, NO-inducible flavohemoprotein.	2.55279e-134
NZ_CP011340.1\|WP_086025651.1\|4611853_4612885_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	3.18018e-37
NZ_CP011340.1\|WP_053557138.1\|4622230_4624195_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|214816	smart00776, NPCBM, This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins.	1.24574e-34
NZ_CP011340.1\|WP_037776596.1\|4628800_4630075_-\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.12628e-60
NZ_CP011340.1\|WP_107082437.1\|4620007_4622158_+\|asparagine-synthase	gnl\|CDD\|273676	TIGR01536, Asparagine_synthetase_1, asparagine synthase (glutamine-hydrolyzing). This model describes the glutamine-hydrolysing asparagine synthase. A poorly conserved C-terminal extension was removed from the model. Bacterial members of the family tend to have a long, poorly conserved insert lacking from archaeal and eukaryotic sequences. Multiple isozymes have been demonstrated, such as in Bacillus subtilis. Long-branch members of the phylogenetic tree (which typically were also second or third candidate members from their genomes) were removed from the seed alignment and score below trusted cutoff. [Amino acid biosynthesis, Aspartate family].	0.00024063
NZ_CP011340.1\|WP_005315409.1\|4630235_4630805_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	6.88678e-20
NZ_CP011340.1\|WP_107082436.1\|4610039_4611398_+\|serine/threonine-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.51906e-43
NZ_CP011340.1\|WP_053557139.1\|4625500_4626976_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	1.52949e-101
NZ_CP011340.1\|WP_037776594.1\|4624393_4625176_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	6.21235e-11
NZ_CP011340.1\|WP_005315416.1\|4636697_4637372_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.32002e-71
NZ_CP011340.1\|WP_005315420.1\|4637368_4638652_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.97231e-40
NZ_CP011340.1\|WP_078535306.1\|4607282_4607996_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.19692e-23
NZ_CP011340.1\|WP_053557135.1\|4613013_4613958_+\|aldo/keto-reductase	gnl\|CDD\|381307	cd19081, AKR_AKR9C1, AKR9C family of aldo-keto reductase (AKR). Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).	3.15571e-156
NZ_CP011340.1\|WP_005315370.1\|4603665_4606704_+\|hypothetical-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	8.09501e-06
NZ_CP011340.1\|WP_005315374.1\|4608154_4608598_+\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|273242	TIGR00738, Putative_HTH-type_transcriptional_regulator, Rrf2 family protein. This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General].	1.91427e-26

>NZ_CP011340.1|WP_106428547.1|4615421_4616168_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MRAKSEPRFPGGPAADPAGSHHERRIRSFQPRRSRVTAGQEDALQRLWPLWGLDIDGHRVLDLEEMFGGLPVVLEIGFGMGEATAQMAADDPGTGILAVDVHTPGQGNLLALAERNGLSNIRVANGDAIILLREMLPPRSLTGMRVYFPDPWPKKRHHKRRLIQPEFLTLAARPLAPGAILHCATDWEPYAEQMLEVLSAHPDFENTQEDGGFAPRPAFRPLTRFEGQGLDKGHKVRDLLFRRVTTRA
>NZ_CP011340.1|WP_053557136.1|4613973_4615350_-|PrsW-family-intramembrane-metalloprotease
MSDPSAQQPPEHRPQRRAVPPHPVLPAREQEHVDASLTEVPAPARRRYRPRAASRIWRSRAFRAGAVITLLALCALVILVLVREQTGTHGFLVGLGLATLPVPLLLAAFRWLDRVEPGPWRNLLFAFAWGAFAAALVAIIANTFATRWIATATADPASADTLGATVIAPVVEESAKAAAILLLFVFRRRDFTGIVDGVVVAGFTATGFAFTENILYLGSAFGEDQAIGTSGLASVTAATFFVRIVMSPFAHPLFTVLTGLGFGVAALGARRHRRLRRIALPLLGLALAMGMHALWNGSASMLGPWGFYAVYGAFMVPAFALLTWLSIWTRQRELRTISEELPAYAAAGWMSAAEPRALSSMRARTVARDFARRAYGPAAGHAVAEYEAFATTLAFLRHRAHRGAAGPDFVEREHELLHHLWQRRDVAGPSLAYAAQATARTPLPPPHRDYSGYNPYRY
>NZ_CP011340.1|WP_053557135.1|4613013_4613958_+|aldo/keto-reductase
MTSLRTLGSSGLTVFPLALGGNVFGWTADEARTFAVLDAYTAAGGNFVDTADSYSSWAPGNEGGESETLIGKWLAARGNRSDVVIATKVGAHPHHKGLSATTIKAAAEESLTRLGTDHIDLYYTHFDDPSVPVEEIITALDQLVKDGKVRAIAASNISAERLRASLDFSEREGLARYVALQPHYNLVSRHTYEGELRDTAARAGLAAVPYYALASGFLTGKYRPGATVDSARAQGASKHLESERGLKVLGALDRIAQDRGAEIATVALAWLAAQPTVAAPIASARTAEQVPALVAVADLALTDGELAELTAASA
>NZ_CP011340.1|WP_086025651.1|4611853_4612885_+|M23-family-metallopeptidase
MPAPEARFASERFSADAPERTWEEWNPTEDSVRPVRGKHRVIKQRGGIARSSTVLGVGVIAAVGAGGIATAQDKPAVSISLPDSIADKLPDAKSLPGVGSLLSDGSDDSDGEVHAAPLTAATTVADTGAGAQAAGSGEALRARILQQAEQQQAEADAEAKAAAEALAAEQAAAAAEKQQSAAEAKAAEEKRKAEEAARAAAEAARLAELARSYSLPTSSYTITSTYGESGAMWSSGQHTGLDFAAPTGTPVKAVHGGTVKSAGWSGSYGYRIVLELEDGTEVLYAHLSSMTASAGQQVSTGETIGRVGATGNVTGPHLHLEVHTAGGSGIDPMAWLRDKGLTI
>NZ_CP011340.1|WP_107082436.1|4610039_4611398_+|serine/threonine-protein-phosphatase
MTPARWSIEKIDHRAGGFSGSATPVARSGDGKSPRGASASSLRWARYCPQPSADPVGPGRRPPLGQEWRDQGGARRAPWFVRVLPMAMIVGGVVFDVLTPPRFTAVPLYAAAPLVAAPVLTWMATLLTGLAALLALSVLHAVNRSFWQITVLTETTTVVTVVVLALFINTLVRRSGQRLASARVIAETAQRAVLPAPADRIGGLHIAARYEAAQAGAFIGGDLFAVQDTPHGVRLLVGDVRGKGLGAVGTVAVLIGAFREAAEQERSLEGVAQRLERALKREGTRREGLDAVEGFTTAVLGEIPRGKALVRLVNRGHPEPLVLRADGALDVLAPAQPALPLGMGDLAAWPDRADEYPLPDGATLLLYTDGVTEARDTRGVFYDPVERLAGRLFPGPGELLDALVDDVRRYTGGGSSDDMALLAVGRPAEGQPEWRRTVPVVPPEPGGRGGSG
>NZ_CP011340.1|WP_053557134.1|4608680_4609871_+|hemin-transporter
MLSEQSVPVVRATLPVVGAAIGDITELFYRKLFDDRPELLRDFFNRGNQATGEQKQALAGSIAAFAGMLLERPEERPDAMLARIANKHASLGVTSEQYKLVHQHLFAAITEVLGDAVTPEVAAAWDEVYWLMANALTAVEARLYQEAGTADGEVWRGMEIVERREETPDVVSFLLQPDDGSPAGAFRPGQYVSVQAELPDGARQIRQYSLSTAPGRPHWRITVKRVRGAAGPQGEVSSWLHGTARVGDRLTVSVPFGDLVLDDGEGPLLLASAGIGSTPMLAMLGHLAATGSARPVVVVHADRDPADHAHREELRRLVDALPSASLHLWYETGGDADAATGQVDIGALDLPEGLTACLCGPLPFMRAVRGDLLRRGVPAAAVHYEVFGPDLWLGQE
>NZ_CP011340.1|WP_005315374.1|4608154_4608598_+|Rrf2-family-transcriptional-regulator
MRLTKFTDLALRAVMRLAVLEQGGPLTTREVAEEMNVPYAHMAKAIARLQHLGVLEARRGRGGGLELTVLGRRASVGWLVRELEGEGEVVACEGDAPCPLRGACRLRRALRDAQEAFHATLDPLTVADLVASPAGPVLVGLSGRRTG
>NZ_CP011340.1|WP_078535306.1|4607282_4607996_-|methyltransferase-domain-containing-protein
MGHPRRPPKGTFVTNGKSDADYEGMRPDRREQAEAFDAIGDSYDDAFPHKEGQVSAGDWLAGALSTGARVLDLGCGTGVPTARRLADAGFQVVGVDLSKEMVRLAQENVPEGEFHQLDIADLRPDGAADLGRFDAVTAFFSLLMLPRAEIPEALRTVRHLLVPGGLFVLSMVEADMDNRAIPFLGKSIRVSGYLREELRKVVEQDFEILEESSYTYAPAISDVPPEEQVFLCCRRRG
>NZ_CP011340.1|WP_005315372.1|4607024_4607198_+|hypothetical-protein
MALEDDCDHTTGIQHDITRTEDEELGAKRYLCGKCGHEYTVPRQDTATEDPGDRPAG
>NZ_CP011340.1|WP_005315370.1|4603665_4606704_+|hypothetical-protein
MAAATLVAGVGPFALTATAAEGDGVVFPAAAASQPRTVVPLVAGPTGYLRYEQGVGHFWSTYAGVSTPISVEEEGPEADGTYGAGLDGFATYLADWTPRSDSVRLVNMATDSVSYLDIPSGHRYVGAFGSTVVTFTQETATAPRAWHLLRLVNGSVQDTPVTGWPEGALPPAKAVTGGADGVLVTYEVGGVPRSGWVDLASAQVRPLPADATARPVSTVHGPTEVVEWAKDGKARFYAKGGADASGPLALTATADLPYNEGDVLLGVVGDRLIVGRASGQASSAPYRVVSVPRTGGDETTLFAHGRGQVMAAPDGGLLLVAGTAADALGVQRLRAEGDGTTAAELADVTPLTSKPRSLSFSHGRLHSLERMPDETNSYRSRTVSVTGELTAGATQEHGDFGFPLEECTDSNGCPEPMATGDGRMVVQPPYGSDLPALVVEPGGTSGRVLSDELENVRINDVSGRYAIGSGRTGTGEWVSNTAFDLDTGKRLATFEVPFDHDLYGDTLWTQGAVNGTVVGYDVRTGAVKRTVDLGTGCRAEFLKVTAHWLSWSCAGIPDRGGIYDLDKNTNLDYTEPFSQLGDGYVVQTHGREVRVTDVRGPEPVLKATYLTSDYNYESGLYAVDTAAGRVAYQENAAGDIRVADLGIPASPLARIDADVATGADLKAGAWKPRWWLSKPAGSWQLTLTSRTTGAVVRTLSGGEARGVVGPVWDGKDTAGRFVGNGAYTWALSVKPADGQGADLTAAGAVSVTGAGAVRRDLVGDDGAGDLLVMDSAGLVSLYKGTGSGGLSARIAGSGGVFPTSSVPVPFGDVNGDRCNDVLVRVGDQLRAYRPGCGRIVSASSPYTLIGTGWGQYDVLTSPGDVNGDGYQDLVARQASTGDMYFYAGTADHRLKSRVKIGTNWKTYTKITGVGDLNGDGHGDLLGIDSAGALWRYYGTASGAVTPRVKLATGWGGYTSVVGVGDISGDGKPELVGRTGDGRLYRHSATGTGTLAARVVIGTGGWQAFKGLY
>NZ_CP011340.1|WP_086025599.1|4617811_4619350_-|sporulation-protein
MRGSRLRVEGWRMSREQRGPNEKLGTVLALAGISNAGLARRVNDLGAQRGLTLRYDKTSVARWVSKGMVPQGAAPHLIAAAIGAKLGRPVPLHEIGLADADPAPEVGLAFPRDVGEAVKSATELYRLDLAGRRAGGGGIWQSLAGSFAVSAYATPASRWLITPADASVERLFDVTGGSSVSSDPAGGSQEAGAVTDSPETADAADTPARVGHSDVAKLREAAEDARRWDSKYGGGDWRSSMVPECLRVDAAPLLLGSYSDEVGRALFGATAELTRLAGWMAFDTGQQEAAQRYYIQALRLARAAADVPLGGYVLASMSLQATYRGFADEGVDLAQAALERNRGLATARTMSFFRLVEARAHAKANDAAAAGAALKAAEGWLERSREGDGDPSWLGFYSYDRFAADAAECYRDLKAPRQVRRFTEQALSRPTEEYVRSHGLRLVVSAVAELESGNLDAACAAGTRAVEVAGRISSARTTEYVRDLLHRLEPYGDEPRVMELRERARPLLMTPA
>NZ_CP011340.1|WP_107082437.1|4620007_4622158_+|asparagine-synthase
MRWLVGWSSIAANFGTAGAVGASEEGRTLHPVGAQLLWGDPDPLWAVGDWRPDEVRVITAEPHQRPYATPGNGQAPTVTRLAVLGCCAASDEQLRVGLFAARGGALRHLTAWAGSYTVVVQVGRRITVVGDLAGARPVFYTPWANGTAYATAALPLADLIEAQLDIGHLAALLACPESPEALRDSTPYAGVKRIPPGHALILREGSREITGYEPVASLAVAAPQVEAARAIDGVRDALVEAVRARLTAPRHAPETLPPDPGPVPGMGPAERRAARGAPTPGIGSDLSGGSASSTLALLAAGLPGVPGTVLGHGTGAGERLLAVTFNDLATSGHELREPELERARLIAANPRLHHVVVAAGEEGLPYANLDSGPLTDEPAPSLVTAERHRGRLAAGSADHFTGTGARQVLDAHPARLADLLLDRRRRHLLRPVTALARSERPSPQSLFVPLTVYRAARKLARTPYRTGLEAAAEDLLLANRPGPALRNGAVGASLAALAWSRPGPAARWLTGEALAEVSVRLTEAATRPTSVQRPGETRARAALARHAFDHRILEQAAEVRSQRLHAPYLDNQVVRACRDLPESLRVQPGARAAVLRTVLGGAGIHDLPPGWGSPTHASSAAAARTGLRSALPHLIALFDAPLLADAGLIEARVVRRALRAASEGEPVPLDGLADLVSTELWLRRLLSRRGTCWTGTAAPRQRAVAGGVPRRPTLQS
>NZ_CP011340.1|WP_053557138.1|4622230_4624195_-|sigma-70-family-RNA-polymerase-sigma-factor
MSGDGRDETLSGAAGREADELSASQVPGQGGRGPSPGGTGSAGPAGRTPDGSRTLSAVPSGQQDHYAVPQQREAGSHDSVLPPPRELPPADAELILRMRDGDDSAYEELFRRHADAVRRYARTCCRDADTADDLTAEVFTRTLQAVRGGAGPEQAVRAYLLTTVRRVAAHWMKTAKREQLVEDFAVFATEAARSADASNEDTLDLGADVRAMHEAERSLAMQAFRSLPERWQAVLWHTTVEEESPSDVAPLFGLTANATAVLASRAREGLKQAYLQAHVSTALTTGGDCARYADRLGAYARGGLRMRAERGLRKHLDECVKCRLAAGELAHVNAGIPALLPVAVIGWFAAGYSLKAAGIVAGGAAGAAGAGAAAAATGGASGGASGGAAGEALGAPAKVGIAAAVAAVAAAGLVWALSGDPQPVPDPVAKPPVAQPVEPPPAPEPEPPAPPAPNPPPPAPAVEPVAAPEPTPAPPRPTPPKPSPTPEPSPSPTPTPTPTPTPTPPPPAPEVYQVSRLEYGTFGDHTGPEVRLGESSWLWQRSSMSIGGTQYAHGATVHAKSSITIDLNRRCTTYEAFVGIDDLTRGLGMGAVRFSVYGDGTRLWSSPVVRSGEPAVPVHVPIAGRTTLRLVAEPETPQDQVALADWAESRITCE
>NZ_CP011340.1|WP_037776594.1|4624393_4625176_-|helix-turn-helix-transcriptional-regulator
MHIQDSHWQTAVAPASTVDGNGNGRAGSGGTSRSAPLRVDAQRNLEHVLRAAREVFGELGYGAPMEDVARRARVGVGTVYRRFPSKDVLVRRIAEEETSRLTEQARTALGQEEEPWSALARFLRTSVASGAGRLLPPQVLRVGVDGDEPTVVTDTDTEPLDDTRVPQQRAMAQPGLRVVAPRPVPVEEQDDSGAADLLEVVGRLVDRARAAGELRGDVTVADVLLVIATAAPSLPDAAQQEAASARLLDILLEGLRPRSL
>NZ_CP011340.1|WP_053557139.1|4625500_4626976_+|NAD(P)/FAD-dependent-oxidoreductase
MVKAANTRGTTPDTPPRKRILVVGGGYVGMYTALRLQRKLKPELARGEMEIVVVTPDPYMTYQPFLPEAAAGSISPRHVVIPLRRVLGRCTIVIGEAKAVDHAKRTATVSTLATEEEGAGAVEITYDELVIAPGSISRTLPVPGLADFGIGFKTVEEAIGLRNHVIEQMDIASSTRDPAIRDAALTFVFVGGGYAGVEALAELEDMARYTSRYYHNIKPEDLKWILVEAQGRILPEVGEQMGRYAVRELRARNIDVRLETRLDSCEDRVAVLSDGSRFPTRTLVWTAGVKPAPVLAATDLPLNERGRLKCTARLSVEGVDHAWAAGDAAAVPDVTSDRPGAECAPNAQHAVRQTKVLAENIVASLRGAPMQDYAHKYAGSVASLGLHKGVAHVYGRKLKGYPAWMMHRAYHLSRVPTFNRKARVLAEWTLSGLFKREIVSLGSLEHPRAEFELAAGGGRPANGSKEQPSAGREEGPQEQSADGSPDGPKGS
>NZ_CP011340.1|WP_037774292.1|4627103_4628783_+|SpoIIE-family-protein-phosphatase
MNFTRWSARLPGTQRRAAARGSDRGLSPAQRSEGSVPAARGEYGHSEPLPDVPALEDFSVPEMLGRLPALVALVHGPEHRIVYVNDAYAAAFGPRPAGATVADVCPELTELGLLPLMDQVLRSGKPRTVKSRRIQGTGESARRGEGSYTITCLPAERADGSKETEGVFVFAADVTDHAEAAERLRASERRHRETAVTLQRSLLPQELEQPDDLRFAATYQPGGIDAAVGGDWYDVITLGAGRTALVIGDVMGRGVRAAAVMGQLRTAVRAYARLDLPPHEVLQLLDGLASEIDASQIATCVYAVHDPNEGRLVYASAGHLPILVRDEDGTVHKAAEPTGPPLGTGGWLHTSGAIDLPPGSTAVLYTDGLVERRGEDIDEGVAALERALSGATGTPQVVCDRLIRSLGVTAEHDDDVAVLVLQHPTRKGADAELFHNAALDLLGGIEAAPRARAFASGVLASWRFPPELHDLGVLAVSELVANSLQHGTPPMRLRLRRTDRRLIVEVTDGDDHLPRRRRAETEDEAGRGISIIATIASSWGSRRTPGGGKAVWCEFALPR
>NZ_CP011340.1|WP_037776596.1|4628800_4630075_-|MFS-transporter
MRRIQAGNALSAFGLGFTVPYLYVYVAQVRDLGASTAGAVLAVFAMAALVALPFTGRVIDRRGPLPVLVAAAVLASAGAVGMGLSGSIPAVVLSAALLGAGTAVMQPALATMIVWCSETATRTRAFATQFFLQNLGLGVGGLIGGHIVDESRPSSFTLLFGIEAAMFLVLAAIALTVRLPHSPTLHDSRPSGAESGAKGGLRALLGHRAMVQLLVLGFVLFFACYGQFESGLAAYGTEAAGIEPATLGTALAANTAVIVLAQFLVLRFVEQRRRSRVIASVGLIWAVAWLAAGYAGLGNGSQAMATAAFISTYALFGLGEAMLSPTVAPLVADLAPEAMVGQYNSAFALVKQLALAVGPAVGGPMGAALHGPYIVTFVLFSLSVTVLALRLGKRLTPVQDRPSLAARTRVVAVHKPEEAVAPAR
>NZ_CP011340.1|WP_005315409.1|4630235_4630805_+|MarR-family-transcriptional-regulator
MPTETPEASLTSGPHEPSLDEQIAAYQREFGDLDPQVEKVVSALGRLNRRMNVAYGRQVADLGISNTEWEVLKTLVLSGSPYRMGPGELAKRLGLTPAAMTHRIDRMAGEGLVTRDRDENNRVRVIVELTDEGRAKWLEAMRMATNFEEDLLQDLSGDERAVLGELLIRVLRRVEHDQPDAGGRLTDLD
>NZ_CP011340.1|WP_005315416.1|4636697_4637372_-|response-regulator-transcription-factor
MTTVLIVDDQPMQRFGFRMLLESQDDMAVVGEAGNGTDAVRQTAELHPDVVLMDIRMPGLDGIEATRRIVASGARTRVLIVTTFDLDEYAYKGLRAGASGFLIKDAMPEELLSGIRAVAAGDAVVAPSLTRRLLDTYVQHLPESTAAGTVEPVPDERLARLTEREREILTVIGQGWTNTEIASRFHLAESTVKTHVSRILAKTGARDRVQAVILAYDTRLVNPS
>NZ_CP011340.1|WP_005315420.1|4637368_4638652_-|sensor-histidine-kinase
MRIARQQRPPRTGPAPQDWSTGAQPLTRRLQRLTERLRAFDRRRPLVWDLHLTGVFVFAALVDAAGGWRNVAFNDEVPSWLVLVMSLGFSVPLLWRRGHPLAVLLVMLPFSLANAASGAHLQASFLQMIAVLNIALRLPLRTLVWSLCTVLVPLAVGATAYPVGSWDQQFVPMLYSFALVALLGLAVRSRQEYTASLVERARQLEVERDQQAQLAAAAERTRIAREMHDIIGHNLSVITGLADGGAYAAASSPQRAAQALEAIGTTSRQALTELRRLLDVLREDGDAPPAAELAPQPALTDLERLVDGVRGAGLPVDLTVEGDPGRLPAGRQLTVYRVVQEALTNSLKHGGPKATATVAVRYGADAVTVTVTDTGAGGDATRTGTGRGLAGMRERTAMYDGTLEAGPLRRPPGGWRVRLHLPKEPDQ

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Crispr_ID: NZ_CP011340_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_12

4612322-4612420

Orphan

Consensus_repeat	Method
GCCGAGGCCAAGGCGGCCGCGGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_12

>merge|NZ_CP011340|12|4612322-4612420|CRISPRCasFinder
GCCGAGGCCAAGGCGGCCGCGGAGGCGCTCGCCGCCGAGCAGGCGGCGGCCGCCGCCGAGAAGCAGCAGAGCGCGGCCGAGGCCAAGGCGGCCGAGGAG

>NZ_CP011340|12|11|4612322-4612420|CRISPRCasFinder
GCCGAGGCCAAGGCGGCCGCGGAG	GCGCTCGCCGCCGAGCAGGCGGCGGCCGCCGCCGAGAAGCAGCAGAGCGCG
GCCGAGGCCAAGGCGGCCGAGGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_053557136.1\|4613973_4615350_-\|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|379143
NZ_CP011340.1\|WP_106428547.1\|4615421_4616168_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP011340.1\|WP_037774292.1\|4627103_4628783_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP011340.1\|WP_053557138.1\|4622230_4624195_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|214816
NZ_CP011340.1\|WP_053557134.1\|4608680_4609871_+\|hemin-transporter	unknown	unknown	gnl\|CDD\|237337
NZ_CP011340.1\|WP_078535306.1\|4607282_4607996_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NZ_CP011340.1\|WP_053557131.1\|4599953_4600316_+\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|223317
NZ_CP011340.1\|WP_107082437.1\|4620007_4622158_+\|asparagine-synthase	unknown	unknown	gnl\|CDD\|273676
NZ_CP011340.1\|WP_053557137.1\|4616441_4617671_-\|L-2-hydroxyglutarate-oxidase	unknown	unknown	gnl\|CDD\|183292
NZ_CP011340.1\|WP_107082436.1\|4610039_4611398_+\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP011340.1\|WP_086025599.1\|4617811_4619350_-\|sporulation-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005315370.1\|4603665_4606704_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379232
NZ_CP011340.1\|WP_053557133.1\|4601242_4603396_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_CP011340.1\|WP_053557139.1\|4625500_4626976_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP011340.1\|WP_005315372.1\|4607024_4607198_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_037776594.1\|4624393_4625176_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP011340.1\|WP_078535504.1\|4599121_4599463_+\|metallopeptidase-family-protein	unknown	unknown	gnl\|CDD\|240572
NZ_CP011340.1\|WP_053557135.1\|4613013_4613958_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381307
NZ_CP011340.1\|WP_005315362.1\|4599459_4599957_+\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|376809
NZ_CP011340.1\|WP_005315374.1\|4608154_4608598_+\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|273242

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_053557136.1\|4613973_4615350_-\|PrsW-family-intramembrane-metalloprotease	gnl\|CDD\|379143	pfam13367, PrsW-protease, Protease prsW family. This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Aflv_1074, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress.	4.54747e-52
NZ_CP011340.1\|WP_106428547.1\|4615421_4616168_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	7.51484e-90
NZ_CP011340.1\|WP_037774292.1\|4627103_4628783_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	3.10795e-50
NZ_CP011340.1\|WP_053557138.1\|4622230_4624195_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|214816	smart00776, NPCBM, This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins.	1.24574e-34
NZ_CP011340.1\|WP_053557134.1\|4608680_4609871_+\|hemin-transporter	gnl\|CDD\|237337	PRK13289, PRK13289, NO-inducible flavohemoprotein.	2.55279e-134
NZ_CP011340.1\|WP_078535306.1\|4607282_4607996_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.19692e-23
NZ_CP011340.1\|WP_053557131.1\|4599953_4600316_+\|CrcB-family-protein	gnl\|CDD\|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	5.98304e-28
NZ_CP011340.1\|WP_107082437.1\|4620007_4622158_+\|asparagine-synthase	gnl\|CDD\|273676	TIGR01536, Asparagine_synthetase_1, asparagine synthase (glutamine-hydrolyzing). This model describes the glutamine-hydrolysing asparagine synthase. A poorly conserved C-terminal extension was removed from the model. Bacterial members of the family tend to have a long, poorly conserved insert lacking from archaeal and eukaryotic sequences. Multiple isozymes have been demonstrated, such as in Bacillus subtilis. Long-branch members of the phylogenetic tree (which typically were also second or third candidate members from their genomes) were removed from the seed alignment and score below trusted cutoff. [Amino acid biosynthesis, Aspartate family].	0.00024063
NZ_CP011340.1\|WP_053557137.1\|4616441_4617671_-\|L-2-hydroxyglutarate-oxidase	gnl\|CDD\|183292	PRK11728, PRK11728, L-2-hydroxyglutarate oxidase.	0
NZ_CP011340.1\|WP_107082436.1\|4610039_4611398_+\|serine/threonine-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.51906e-43
NZ_CP011340.1\|WP_005315370.1\|4603665_4606704_+\|hypothetical-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	8.09501e-06
NZ_CP011340.1\|WP_053557133.1\|4601242_4603396_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	4.95032e-120
NZ_CP011340.1\|WP_053557139.1\|4625500_4626976_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	1.52949e-101
NZ_CP011340.1\|WP_037776594.1\|4624393_4625176_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	6.21235e-11
NZ_CP011340.1\|WP_078535504.1\|4599121_4599463_+\|metallopeptidase-family-protein	gnl\|CDD\|240572	cd12952, MMP_ACEL2062, Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein. The subfamily includes an uncharacterized protein from Acidothermus cellulolyticus (ACEL2062) and its homologs from bacteria. Although its biological role remains unclear, ACEL2062 contains a minimal metalloprotease (MMP)-like domain consisting of 3-stranded mixed 2-beta sheets and a HExxHxxGxxD/S (x could be any amino acid) motif. It may belong to a superfamily of bacterial zinc metallo-peptidases, which is characterized by a conserved HExxHxxGxxD motif.	7.93105e-47
NZ_CP011340.1\|WP_053557135.1\|4613013_4613958_+\|aldo/keto-reductase	gnl\|CDD\|381307	cd19081, AKR_AKR9C1, AKR9C family of aldo-keto reductase (AKR). Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).	3.15571e-156
NZ_CP011340.1\|WP_005315362.1\|4599459_4599957_+\|CrcB-family-protein	gnl\|CDD\|376809	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB). CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance.	7.56376e-30
NZ_CP011340.1\|WP_005315374.1\|4608154_4608598_+\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|273242	TIGR00738, Putative_HTH-type_transcriptional_regulator, Rrf2 family protein. This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General].	1.91427e-26

>NZ_CP011340.1|WP_107082436.1|4610039_4611398_+|serine/threonine-protein-phosphatase
MTPARWSIEKIDHRAGGFSGSATPVARSGDGKSPRGASASSLRWARYCPQPSADPVGPGRRPPLGQEWRDQGGARRAPWFVRVLPMAMIVGGVVFDVLTPPRFTAVPLYAAAPLVAAPVLTWMATLLTGLAALLALSVLHAVNRSFWQITVLTETTTVVTVVVLALFINTLVRRSGQRLASARVIAETAQRAVLPAPADRIGGLHIAARYEAAQAGAFIGGDLFAVQDTPHGVRLLVGDVRGKGLGAVGTVAVLIGAFREAAEQERSLEGVAQRLERALKREGTRREGLDAVEGFTTAVLGEIPRGKALVRLVNRGHPEPLVLRADGALDVLAPAQPALPLGMGDLAAWPDRADEYPLPDGATLLLYTDGVTEARDTRGVFYDPVERLAGRLFPGPGELLDALVDDVRRYTGGGSSDDMALLAVGRPAEGQPEWRRTVPVVPPEPGGRGGSG
>NZ_CP011340.1|WP_053557134.1|4608680_4609871_+|hemin-transporter
MLSEQSVPVVRATLPVVGAAIGDITELFYRKLFDDRPELLRDFFNRGNQATGEQKQALAGSIAAFAGMLLERPEERPDAMLARIANKHASLGVTSEQYKLVHQHLFAAITEVLGDAVTPEVAAAWDEVYWLMANALTAVEARLYQEAGTADGEVWRGMEIVERREETPDVVSFLLQPDDGSPAGAFRPGQYVSVQAELPDGARQIRQYSLSTAPGRPHWRITVKRVRGAAGPQGEVSSWLHGTARVGDRLTVSVPFGDLVLDDGEGPLLLASAGIGSTPMLAMLGHLAATGSARPVVVVHADRDPADHAHREELRRLVDALPSASLHLWYETGGDADAATGQVDIGALDLPEGLTACLCGPLPFMRAVRGDLLRRGVPAAAVHYEVFGPDLWLGQE
>NZ_CP011340.1|WP_005315374.1|4608154_4608598_+|Rrf2-family-transcriptional-regulator
MRLTKFTDLALRAVMRLAVLEQGGPLTTREVAEEMNVPYAHMAKAIARLQHLGVLEARRGRGGGLELTVLGRRASVGWLVRELEGEGEVVACEGDAPCPLRGACRLRRALRDAQEAFHATLDPLTVADLVASPAGPVLVGLSGRRTG
>NZ_CP011340.1|WP_078535306.1|4607282_4607996_-|methyltransferase-domain-containing-protein
MGHPRRPPKGTFVTNGKSDADYEGMRPDRREQAEAFDAIGDSYDDAFPHKEGQVSAGDWLAGALSTGARVLDLGCGTGVPTARRLADAGFQVVGVDLSKEMVRLAQENVPEGEFHQLDIADLRPDGAADLGRFDAVTAFFSLLMLPRAEIPEALRTVRHLLVPGGLFVLSMVEADMDNRAIPFLGKSIRVSGYLREELRKVVEQDFEILEESSYTYAPAISDVPPEEQVFLCCRRRG
>NZ_CP011340.1|WP_005315372.1|4607024_4607198_+|hypothetical-protein
MALEDDCDHTTGIQHDITRTEDEELGAKRYLCGKCGHEYTVPRQDTATEDPGDRPAG
>NZ_CP011340.1|WP_005315370.1|4603665_4606704_+|hypothetical-protein
MAAATLVAGVGPFALTATAAEGDGVVFPAAAASQPRTVVPLVAGPTGYLRYEQGVGHFWSTYAGVSTPISVEEEGPEADGTYGAGLDGFATYLADWTPRSDSVRLVNMATDSVSYLDIPSGHRYVGAFGSTVVTFTQETATAPRAWHLLRLVNGSVQDTPVTGWPEGALPPAKAVTGGADGVLVTYEVGGVPRSGWVDLASAQVRPLPADATARPVSTVHGPTEVVEWAKDGKARFYAKGGADASGPLALTATADLPYNEGDVLLGVVGDRLIVGRASGQASSAPYRVVSVPRTGGDETTLFAHGRGQVMAAPDGGLLLVAGTAADALGVQRLRAEGDGTTAAELADVTPLTSKPRSLSFSHGRLHSLERMPDETNSYRSRTVSVTGELTAGATQEHGDFGFPLEECTDSNGCPEPMATGDGRMVVQPPYGSDLPALVVEPGGTSGRVLSDELENVRINDVSGRYAIGSGRTGTGEWVSNTAFDLDTGKRLATFEVPFDHDLYGDTLWTQGAVNGTVVGYDVRTGAVKRTVDLGTGCRAEFLKVTAHWLSWSCAGIPDRGGIYDLDKNTNLDYTEPFSQLGDGYVVQTHGREVRVTDVRGPEPVLKATYLTSDYNYESGLYAVDTAAGRVAYQENAAGDIRVADLGIPASPLARIDADVATGADLKAGAWKPRWWLSKPAGSWQLTLTSRTTGAVVRTLSGGEARGVVGPVWDGKDTAGRFVGNGAYTWALSVKPADGQGADLTAAGAVSVTGAGAVRRDLVGDDGAGDLLVMDSAGLVSLYKGTGSGGLSARIAGSGGVFPTSSVPVPFGDVNGDRCNDVLVRVGDQLRAYRPGCGRIVSASSPYTLIGTGWGQYDVLTSPGDVNGDGYQDLVARQASTGDMYFYAGTADHRLKSRVKIGTNWKTYTKITGVGDLNGDGHGDLLGIDSAGALWRYYGTASGAVTPRVKLATGWGGYTSVVGVGDISGDGKPELVGRTGDGRLYRHSATGTGTLAARVVIGTGGWQAFKGLY
>NZ_CP011340.1|WP_053557133.1|4601242_4603396_+|DEAD/DEAH-box-helicase
MSTFSTDHAVMPENDEIVETVVVDAAEAAEASEEPQTTFSDLGLPEGVVRKLAQNGVTTPFPIQAATIPDALAGKDILGRGRTGSGKTLSFGLPTLATLAGGHTEKKKPRAIILTPTRELAMQVADALQPYGDVLGLKMKVVCGGTSMGNQIYALERGVDVLVATPGRLRDIINRGACSLENVRVAVLDEADQMSDLGFLPEVTELLDQIPAGGQRMLFSATMENEISTLVKRYLTDPVTHEVDSAQGNVTTMSHHVLVVKPKDKAPVTAAIAARKGRTIIFVRTQLGADRIAEQLRESGVKADALHGGMTQGARTRTLADFKEGYVNALVATDVAARGIHVDGIDLVLNVDPAGDHKDYLHRSGRTARAGKSGVVVSLSLPHQRRQIFRLMEDAGVDASRHIVGGAGAFDPEVAEITGARSLTEVQADSANNAAKQAEREVVELTRQLERVQRRATELREEADRLVARAARERGEDPEAAVAEVTEAAVAELAAVPEQAEPVRDSRDERPSSDRRDERGNFRRDDRRDDRGGRSFERRDDRGGDRGGDRGGFRRDDRGGRSFERRDGDRGGFRRDNDRGGDRGGFRRDDRRDDRGGRTFERRDDRGGDRGGFRREDDRGGRSFERRDGDRGGFRRDNDRGGDRGGFRRDDRPAGHRGSDRPFNRDRRDDRPSSGFRPGAGDRPYGRRDDHRGGAGSSSGSFGGGRRDDKPRWKRNG
>NZ_CP011340.1|WP_053557131.1|4599953_4600316_+|CrcB-family-protein
MNWLLVMVGAALGAPLRYLTDRAVQVRHDSVFPWGTFVVNAAGSLLLGAVAGAAVSSPAYTLLGTGLCGALTTYSTFSYETLRLAERGWRFLAAANVGASVLVGLGSVFLGLELARALTA
>NZ_CP011340.1|WP_005315362.1|4599459_4599957_+|CrcB-family-protein
MRSGADAAGGAEAIDPDVDLHVPAQRAETAGGRKWPVLAAISAGGAVGACARYGATLLWPTPEGTFPWAIFWVNVSGCALIGVLMVLVSEKGRTAPPLVRPFLGVGVLGGFTTFSTYAHDFSGLLEREEAGIALAYAGGTLAGAMGAVWLGASATRAALGRTAAS
>NZ_CP011340.1|WP_078535504.1|4599121_4599463_+|metallopeptidase-family-protein
MTREEFEELVSEALDRIPPELTRLMDNVAVFVEDEPASDDPDLLGLYEGTPLTDRGEWYAGVLPDRITIYRGPTLRMCESREDVVAETEITVVHEIAHHFGIDDERLHELGYG
>NZ_CP011340.1|WP_053557135.1|4613013_4613958_+|aldo/keto-reductase
MTSLRTLGSSGLTVFPLALGGNVFGWTADEARTFAVLDAYTAAGGNFVDTADSYSSWAPGNEGGESETLIGKWLAARGNRSDVVIATKVGAHPHHKGLSATTIKAAAEESLTRLGTDHIDLYYTHFDDPSVPVEEIITALDQLVKDGKVRAIAASNISAERLRASLDFSEREGLARYVALQPHYNLVSRHTYEGELRDTAARAGLAAVPYYALASGFLTGKYRPGATVDSARAQGASKHLESERGLKVLGALDRIAQDRGAEIATVALAWLAAQPTVAAPIASARTAEQVPALVAVADLALTDGELAELTAASA
>NZ_CP011340.1|WP_053557136.1|4613973_4615350_-|PrsW-family-intramembrane-metalloprotease
MSDPSAQQPPEHRPQRRAVPPHPVLPAREQEHVDASLTEVPAPARRRYRPRAASRIWRSRAFRAGAVITLLALCALVILVLVREQTGTHGFLVGLGLATLPVPLLLAAFRWLDRVEPGPWRNLLFAFAWGAFAAALVAIIANTFATRWIATATADPASADTLGATVIAPVVEESAKAAAILLLFVFRRRDFTGIVDGVVVAGFTATGFAFTENILYLGSAFGEDQAIGTSGLASVTAATFFVRIVMSPFAHPLFTVLTGLGFGVAALGARRHRRLRRIALPLLGLALAMGMHALWNGSASMLGPWGFYAVYGAFMVPAFALLTWLSIWTRQRELRTISEELPAYAAAGWMSAAEPRALSSMRARTVARDFARRAYGPAAGHAVAEYEAFATTLAFLRHRAHRGAAGPDFVEREHELLHHLWQRRDVAGPSLAYAAQATARTPLPPPHRDYSGYNPYRY
>NZ_CP011340.1|WP_106428547.1|4615421_4616168_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MRAKSEPRFPGGPAADPAGSHHERRIRSFQPRRSRVTAGQEDALQRLWPLWGLDIDGHRVLDLEEMFGGLPVVLEIGFGMGEATAQMAADDPGTGILAVDVHTPGQGNLLALAERNGLSNIRVANGDAIILLREMLPPRSLTGMRVYFPDPWPKKRHHKRRLIQPEFLTLAARPLAPGAILHCATDWEPYAEQMLEVLSAHPDFENTQEDGGFAPRPAFRPLTRFEGQGLDKGHKVRDLLFRRVTTRA
>NZ_CP011340.1|WP_053557137.1|4616441_4617671_-|L-2-hydroxyglutarate-oxidase
MRASGHDFDCDVLVVGGGIVGLSTAYALSRSAPGTRVTVLEKEQGPARHQTGRNSGVIHSGIYYRPGSLKARFAVRGAAEMVKFCAEYGIGHEVTGKLIVATDRDELPRLHALVQRGRENGIPVRELGPAQISEYEPEVRGLAAIHVATTGICDYGAVAAQLATASGADVRYGEEVTAVDRRPWGVAVRTRSGTVVRARVLVNCAGLHCDRVARLAGDDPGMRIVPFRGEYYDLARPGLVRGLVYPVPDPAFPFLGVHLTRGIDGGVHVGPNAVPALAREGYRWSAVRPLELAGTLGWPGSWHIARRHWRYGAGELRRSLSKRAFTSAVRRLLPAVTEDDLRPAPAGVRAQAVLRDGTLADDFLIREAPRTVHVLNAPSPAATASLPIGREVARRALTALEPSRPRTAR
>NZ_CP011340.1|WP_086025599.1|4617811_4619350_-|sporulation-protein
MRGSRLRVEGWRMSREQRGPNEKLGTVLALAGISNAGLARRVNDLGAQRGLTLRYDKTSVARWVSKGMVPQGAAPHLIAAAIGAKLGRPVPLHEIGLADADPAPEVGLAFPRDVGEAVKSATELYRLDLAGRRAGGGGIWQSLAGSFAVSAYATPASRWLITPADASVERLFDVTGGSSVSSDPAGGSQEAGAVTDSPETADAADTPARVGHSDVAKLREAAEDARRWDSKYGGGDWRSSMVPECLRVDAAPLLLGSYSDEVGRALFGATAELTRLAGWMAFDTGQQEAAQRYYIQALRLARAAADVPLGGYVLASMSLQATYRGFADEGVDLAQAALERNRGLATARTMSFFRLVEARAHAKANDAAAAGAALKAAEGWLERSREGDGDPSWLGFYSYDRFAADAAECYRDLKAPRQVRRFTEQALSRPTEEYVRSHGLRLVVSAVAELESGNLDAACAAGTRAVEVAGRISSARTTEYVRDLLHRLEPYGDEPRVMELRERARPLLMTPA
>NZ_CP011340.1|WP_107082437.1|4620007_4622158_+|asparagine-synthase
MRWLVGWSSIAANFGTAGAVGASEEGRTLHPVGAQLLWGDPDPLWAVGDWRPDEVRVITAEPHQRPYATPGNGQAPTVTRLAVLGCCAASDEQLRVGLFAARGGALRHLTAWAGSYTVVVQVGRRITVVGDLAGARPVFYTPWANGTAYATAALPLADLIEAQLDIGHLAALLACPESPEALRDSTPYAGVKRIPPGHALILREGSREITGYEPVASLAVAAPQVEAARAIDGVRDALVEAVRARLTAPRHAPETLPPDPGPVPGMGPAERRAARGAPTPGIGSDLSGGSASSTLALLAAGLPGVPGTVLGHGTGAGERLLAVTFNDLATSGHELREPELERARLIAANPRLHHVVVAAGEEGLPYANLDSGPLTDEPAPSLVTAERHRGRLAAGSADHFTGTGARQVLDAHPARLADLLLDRRRRHLLRPVTALARSERPSPQSLFVPLTVYRAARKLARTPYRTGLEAAAEDLLLANRPGPALRNGAVGASLAALAWSRPGPAARWLTGEALAEVSVRLTEAATRPTSVQRPGETRARAALARHAFDHRILEQAAEVRSQRLHAPYLDNQVVRACRDLPESLRVQPGARAAVLRTVLGGAGIHDLPPGWGSPTHASSAAAARTGLRSALPHLIALFDAPLLADAGLIEARVVRRALRAASEGEPVPLDGLADLVSTELWLRRLLSRRGTCWTGTAAPRQRAVAGGVPRRPTLQS
>NZ_CP011340.1|WP_053557138.1|4622230_4624195_-|sigma-70-family-RNA-polymerase-sigma-factor
MSGDGRDETLSGAAGREADELSASQVPGQGGRGPSPGGTGSAGPAGRTPDGSRTLSAVPSGQQDHYAVPQQREAGSHDSVLPPPRELPPADAELILRMRDGDDSAYEELFRRHADAVRRYARTCCRDADTADDLTAEVFTRTLQAVRGGAGPEQAVRAYLLTTVRRVAAHWMKTAKREQLVEDFAVFATEAARSADASNEDTLDLGADVRAMHEAERSLAMQAFRSLPERWQAVLWHTTVEEESPSDVAPLFGLTANATAVLASRAREGLKQAYLQAHVSTALTTGGDCARYADRLGAYARGGLRMRAERGLRKHLDECVKCRLAAGELAHVNAGIPALLPVAVIGWFAAGYSLKAAGIVAGGAAGAAGAGAAAAATGGASGGASGGAAGEALGAPAKVGIAAAVAAVAAAGLVWALSGDPQPVPDPVAKPPVAQPVEPPPAPEPEPPAPPAPNPPPPAPAVEPVAAPEPTPAPPRPTPPKPSPTPEPSPSPTPTPTPTPTPTPPPPAPEVYQVSRLEYGTFGDHTGPEVRLGESSWLWQRSSMSIGGTQYAHGATVHAKSSITIDLNRRCTTYEAFVGIDDLTRGLGMGAVRFSVYGDGTRLWSSPVVRSGEPAVPVHVPIAGRTTLRLVAEPETPQDQVALADWAESRITCE
>NZ_CP011340.1|WP_037776594.1|4624393_4625176_-|helix-turn-helix-transcriptional-regulator
MHIQDSHWQTAVAPASTVDGNGNGRAGSGGTSRSAPLRVDAQRNLEHVLRAAREVFGELGYGAPMEDVARRARVGVGTVYRRFPSKDVLVRRIAEEETSRLTEQARTALGQEEEPWSALARFLRTSVASGAGRLLPPQVLRVGVDGDEPTVVTDTDTEPLDDTRVPQQRAMAQPGLRVVAPRPVPVEEQDDSGAADLLEVVGRLVDRARAAGELRGDVTVADVLLVIATAAPSLPDAAQQEAASARLLDILLEGLRPRSL
>NZ_CP011340.1|WP_053557139.1|4625500_4626976_+|NAD(P)/FAD-dependent-oxidoreductase
MVKAANTRGTTPDTPPRKRILVVGGGYVGMYTALRLQRKLKPELARGEMEIVVVTPDPYMTYQPFLPEAAAGSISPRHVVIPLRRVLGRCTIVIGEAKAVDHAKRTATVSTLATEEEGAGAVEITYDELVIAPGSISRTLPVPGLADFGIGFKTVEEAIGLRNHVIEQMDIASSTRDPAIRDAALTFVFVGGGYAGVEALAELEDMARYTSRYYHNIKPEDLKWILVEAQGRILPEVGEQMGRYAVRELRARNIDVRLETRLDSCEDRVAVLSDGSRFPTRTLVWTAGVKPAPVLAATDLPLNERGRLKCTARLSVEGVDHAWAAGDAAAVPDVTSDRPGAECAPNAQHAVRQTKVLAENIVASLRGAPMQDYAHKYAGSVASLGLHKGVAHVYGRKLKGYPAWMMHRAYHLSRVPTFNRKARVLAEWTLSGLFKREIVSLGSLEHPRAEFELAAGGGRPANGSKEQPSAGREEGPQEQSADGSPDGPKGS
>NZ_CP011340.1|WP_037774292.1|4627103_4628783_+|SpoIIE-family-protein-phosphatase
MNFTRWSARLPGTQRRAAARGSDRGLSPAQRSEGSVPAARGEYGHSEPLPDVPALEDFSVPEMLGRLPALVALVHGPEHRIVYVNDAYAAAFGPRPAGATVADVCPELTELGLLPLMDQVLRSGKPRTVKSRRIQGTGESARRGEGSYTITCLPAERADGSKETEGVFVFAADVTDHAEAAERLRASERRHRETAVTLQRSLLPQELEQPDDLRFAATYQPGGIDAAVGGDWYDVITLGAGRTALVIGDVMGRGVRAAAVMGQLRTAVRAYARLDLPPHEVLQLLDGLASEIDASQIATCVYAVHDPNEGRLVYASAGHLPILVRDEDGTVHKAAEPTGPPLGTGGWLHTSGAIDLPPGSTAVLYTDGLVERRGEDIDEGVAALERALSGATGTPQVVCDRLIRSLGVTAEHDDDVAVLVLQHPTRKGADAELFHNAALDLLGGIEAAPRARAFASGVLASWRFPPELHDLGVLAVSELVANSLQHGTPPMRLRLRRTDRRLIVEVTDGDDHLPRRRRAETEDEAGRGISIIATIASSWGSRRTPGGGKAVWCEFALPR

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Crispr_ID: NZ_CP011340_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_14

5128880-5128958

Unclear

Consensus_repeat	Method
CGGGCTGCCTGCCCGGCGCTGCATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_14

>merge|NZ_CP011340|14|5128880-5128958|CRISPRCasFinder
CGGGCTGCCTGCCCGGCGCTGCATTGCCACGAATCCGGGCGGGCGCCGCGAACCCGGGCTGCCTGCCCCGCGCTGCATT

>NZ_CP011340|14|13|5128880-5128958|CRISPRCasFinder
CGGGCTGCCTGCCCGGCGCTGCATT	GCCACGAATCCGGGCGGGCGCCGCGAACC
CGGGCTGCCTGCCCCGCGCTGCATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_005316619.1\|5140358_5141147_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP011340.1\|WP_005316584.1\|5120605_5121076_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005316590.1\|5124336_5125314_-\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|179535
NZ_CP011340.1\|WP_005316616.1\|5138448_5139972_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
NZ_CP011340.1\|WP_037774454.1\|5129695_5130202_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373065
NZ_CP011340.1\|WP_005316599.1\|5129193_5129685_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379608
NZ_CP011340.1\|WP_053557200.1\|5127491_5128814_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP011340.1\|WP_005316593.1\|5125438_5126914_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl\|CDD\|184641
NZ_CP011340.1\|WP_053557199.1\|5121376_5122606_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NZ_CP011340.1\|WP_053557203.1\|5134709_5136311_-\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
NZ_CP011340.1\|WP_005316612.1\|5136307_5136781_-\|DUF485-domain-containing-protein	unknown	unknown	gnl\|CDD\|377315
NZ_CP011340.1\|WP_005316587.1\|5122749_5123343_-\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NZ_CP011340.1\|WP_078951276.1\|5130433_5131447_+\|cell-wall-assembly-protein-Knr4	unknown	unknown	gnl\|CDD\|378155
NZ_CP011340.1\|WP_053557202.1\|5131454_5134235_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373070
NZ_CP011340.1\|WP_005316621.1\|5141143_5143714_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NZ_CP011340.1\|WP_005316581.1\|5119736_5120423_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|235899
NZ_CP011340.1\|WP_005316588.1\|5123446_5124043_-\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	unknown	unknown	gnl\|CDD\|235534
NZ_CP011340.1\|WP_005316577.1\|5115668_5116679_-\|stearoyl-CoA-9-desaturase	unknown	unknown	gnl\|CDD\|224316
NZ_CP011340.1\|WP_005316579.1\|5116895_5119625_+\|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl\|CDD\|366019
NZ_CP011340.1\|WP_005316615.1\|5136939_5138223_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_005316619.1\|5140358_5141147_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.20661e-111
NZ_CP011340.1\|WP_005316587.1\|5122749_5123343_-\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	1.82303e-94
NZ_CP011340.1\|WP_005316590.1\|5124336_5125314_-\|ribose-phosphate-diphosphokinase	gnl\|CDD\|179535	PRK03092, PRK03092, ribose-phosphate diphosphokinase.	0
NZ_CP011340.1\|WP_005316616.1\|5138448_5139972_-\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.57114e-59
NZ_CP011340.1\|WP_037774454.1\|5129695_5130202_-\|hypothetical-protein	gnl\|CDD\|373065	pfam14431, YwqJ-deaminase, YwqJ-like deaminase. A member of the nucleic acid/nucleotide deaminase superfamily prototyped by Bacillus YwqJ. Members of this family are present in a wide phyletic range of bacteria and a few basidiomycetes. Bacterial versions are predicted to function as toxins in bacterial polymorphic toxin systems.	5.1571e-16
NZ_CP011340.1\|WP_005316599.1\|5129193_5129685_-\|hypothetical-protein	gnl\|CDD\|379608	pfam14433, SUKH-3, SUKH-3 immunity protein. This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems.	1.7442e-64
NZ_CP011340.1\|WP_053557200.1\|5127491_5128814_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.57213e-33
NZ_CP011340.1\|WP_005316593.1\|5125438_5126914_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl\|CDD\|184641	PRK14352, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NZ_CP011340.1\|WP_053557199.1\|5121376_5122606_-\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.15238e-31
NZ_CP011340.1\|WP_053557203.1\|5134709_5136311_-\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	1.6282e-125
NZ_CP011340.1\|WP_005316615.1\|5136939_5138223_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.89426e-41
NZ_CP011340.1\|WP_005316612.1\|5136307_5136781_-\|DUF485-domain-containing-protein	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	1.49892e-20
NZ_CP011340.1\|WP_078951276.1\|5130433_5131447_+\|cell-wall-assembly-protein-Knr4	gnl\|CDD\|378155	pfam09346, SMI1_KNR4, SMI1 / KNR4 family (SUKH-1). Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.	5.40223e-11
NZ_CP011340.1\|WP_053557202.1\|5131454_5134235_+\|hypothetical-protein	gnl\|CDD\|373070	pfam14440, XOO_2897-deam, Xanthomonas XOO_2897-like deaminase. A member of the nucleic acid/nucleotide deaminase superfamily prototyped by Xanthomonas XOO_2897. Members of this family are present in a wide phyletic range of bacteria and are predicted to function as toxins in bacterial polymorphic toxin systems. The Xanthomonas XOO_2897 lack an immunity protein and is predicted to be deployed against its eukaryotic host.	7.94352e-37
NZ_CP011340.1\|WP_005316621.1\|5141143_5143714_+\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	6.08707e-28
NZ_CP011340.1\|WP_005316581.1\|5119736_5120423_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|235899	PRK06975, PRK06975, bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed.	8.31463e-05
NZ_CP011340.1\|WP_005316588.1\|5123446_5124043_-\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	gnl\|CDD\|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	3.49451e-69
NZ_CP011340.1\|WP_005316577.1\|5115668_5116679_-\|stearoyl-CoA-9-desaturase	gnl\|CDD\|224316	COG1398, OLE1, Fatty-acid desaturase [Lipid metabolism].	4.4107e-70
NZ_CP011340.1\|WP_005316579.1\|5116895_5119625_+\|phosphoenolpyruvate-carboxylase	gnl\|CDD\|366019	pfam00311, PEPcase, Phosphoenolpyruvate carboxylase.	0

>NZ_CP011340.1|WP_053557200.1|5127491_5128814_+|sensor-histidine-kinase
MTTTGAQQEASGSTARGPLWWRRRRSAVLDVGLAVASAVECALQGVGFADQAALPVPLGVLFGLVVGSVLVLRRRWPIAVVLVSIATTPAEMGFLMGLVGLYTLAASDVPRRITATLAGMALSATFIVTFVRVRQDVEAGDYSAPYVPLMAVFMSLGLTAPPVLLGLYIGARRRLMESLRERADSLEQELSLLADRAEQRAQWARQEERTRIAREMHDVVAHRVSLMVVHAAALQAVALKDPQKAVKNAALVGDMGRQALTELREMLGVLRSGESGVRARSDVPPLAAVGAAAAAAAAAAAEDGPCIADIDVLVGQSRQAGMVVELAVQGDVRAYPPEVEQTAYRVIQEALTNVHKHAAGAKVMVRLAHRDEEVAMQVENGAPDAAGGAADAGLPSGGNGLVGMRERVTALGGVFVSGPTDAGGFRVSAVLPDRAEVSLR
>NZ_CP011340.1|WP_005316593.1|5125438_5126914_-|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MSANRPAAVVVLAAGEGTRMKSKTPKVLHEIAGRSLVGHVVSAARELGPEQLVVVVGHAREQVEAHLGEHYAGTRTAFQAEQNGTGHAVRMGLEELGDAWGSPQAEGSGGGTVVVVCGDTPLLSGATLSALTATHTADGNAVTVLTAEVPDSTGYGRIVRDAATGAVTAIVEHKDATDEQRAIREINSGVFAFDGQLLADALTKVRTDNSQGEEYLTDVLGILREAGHRVGASVAGDHREILGINNRVQLAEARRLMNERLLEQAMMAGVTVVDPASVIVDVTVTFEPDAVVHPGTQLLGATHIGEGAEVGPNSRLTNTTVRAGARVDNTVADSATVGEGATVGPFAYLRPGTRLGVKAKAGTFVEVKNSSLGEGTKVPHLSYVGDATIGDYTNIGAASVFVNYDGESKHHTTIGSHCRTGSDNMFVAPVTVGDGAYTAAGSVITKDVPAGSLAVARGQQRNIEGWVARKRPGSAAAQAAAVATEQVAEEN
>NZ_CP011340.1|WP_005316590.1|5124336_5125314_-|ribose-phosphate-diphosphokinase
MTGIKTTGEKKLMLFSGRAHPELAEEVAHQLGVGLVPTKAFDFANGEIYVRFQESARGADCFLIQSHTAPINKWIMEQLIMIDALKRASARSITVIIPSYGYARQDKKHRGREPISARLIADMLKCAGAHRILTVDLHTDQIQGFFDGPVDHLSALPVLADYVGAKVDRDKLTIVSPDAGRVRVADRWCDRLDAPLAIVHKRRDKDVANQVTVHEVVGEVKGRVCVLVDDMIDTGGTICAAADALFAHGAEDVIVTATHGILSGPAADRLKNSKVSEFVLTNTLPTPGELELDKIKVLSIAPTIARAVREVFEDGSVTSLFEEQA
>NZ_CP011340.1|WP_005316588.1|5123446_5124043_-|50S-ribosomal-protein-L25/general-stress-protein-Ctc
MSEVKLTAERRSEFGKGAARRIRRDNKVPGVLYGHGTDPVHVTLPGHELLLALRTPNVLISLDLGGTSELAIPKAVQRDPLKGFLEHVDLLLVKRGEKVSVDIPVHTEGDLAPGAFLVEHVLNALPVEAEATHIPESVTVSIEGLSAGDSVLAKDITLPKGTTLTVEDDTVVLQVLAAQAEEPAAEGAEGEGEEAAEA
>NZ_CP011340.1|WP_005316587.1|5122749_5123343_-|aminoacyl-tRNA-hydrolase
MSDTNAPWLIVGLGNPGPGYAANRHNVGFMVADLLAERIGGSFKRAGKAQAQALEGRIGAPGPSNRRVILAKPMSYMNLSGGPVTALRDFYKVPTSNIVAVHDELDIDYGTLRLKLGGGDNGHNGLKSMTKAMGPDYHRVRFGIGRPPGRMQVADFVLKDFSSAERKELDYFVDRAADAVECLVIDGLERAQGTYNS
>NZ_CP011340.1|WP_053557199.1|5121376_5122606_-|MFS-transporter
MPNLLPPAGPQRTLALAQLSNSVGDGAYYVTSALYFTHVVGLPPTRIGLGLTVAWAVGSVVGVPLGRVADRRGPRGTAVLLALATGAAVASFLAVRDFLPFLAAACLYATAQSGLAAARQALLAGLVAKEERTGALAHLQSTLNAGLAVGAGLGGVALSVGTRSAYLAVFAIDALSFLLCALVLLRLPAVAPVHVARGAKLEVLRDRPYAVVTLLNTVLLLRMPLLSLGLPLWITERTDAPEWLVSALFILNTGAVVLFQVRTARSVTGLGTAARAVRRSGVLMLLTCATFAVSAGTPPWVAITALVGGSVLLVAAEMLQSAGAWQLGFDLAPAGRIGEYQGFFGAGVTIARSAGPLLLTALLMGSGAAGWLLLGGLFLVTSCALGPATRWAARTRHAPAPTGAATRTA
>NZ_CP011340.1|WP_005316584.1|5120605_5121076_-|hypothetical-protein
MKRNSSGRILVLARGAAMALVALLLLVAGFWSSWGTAQHIMLSKGREHGTLAVTRCDDDTCTGAYTPKAPAPDRAQVTIEKSVAVKKGRTLDVVLKPGTAEAVRTGPAGGLYAWVPLGGALLLAALVIGGGLRLTRLAWGAAGVGGALLLASFLAL
>NZ_CP011340.1|WP_005316581.1|5119736_5120423_-|LPXTG-cell-wall-anchor-domain-containing-protein
MRTLTATGALLAAAALSLTAAPAALATPPGDNGTVKIHDATTGEELRKNEPKVCTFYLDAFGFDAGQKVDWHIEAWAANDLDKGTSVKAGSITLDADGHERTEDLTLPDGQYKLFWNFEGEHGSAKHKVFKTDCEGEGPAPSATPSTTPSGKPGEEPSSTPTAPDASSPAASAPGGGDGPAPSADGASGDLAETGNGAPVGALAAAAAALVATGGYLLARRRTAGRQH
>NZ_CP011340.1|WP_005316579.1|5116895_5119625_+|phosphoenolpyruvate-carboxylase
MSSADQTPTASAELRADIRRLGDLLGETLVRQEGPELLDLVERVRALTRTDGEAAAELLGDTDLETAAKLVRAFSTYFHLANVTEQVHRGHEMRARRAAEGGLLAITADRLKDADPQHLRETVKNLNVRPVFTAHPTEAARRSVLNKLRRIAELLESPVIAADRRRHDLRLAEHIDLIWQTDELRVVRPEPADEARNAIYYLDELHAGAVGDVLEDLAAELERVGVELPPGTRPLTFGTWIGGDRDGNPNVTPAVTWEVLILQHEHGITDAIEVIDYLRGLLSNSIRYAGATEELLASLQTDLERLPEISPRYKRLNAEEPYRLKATCIRQKLVNTRERLAKGTPHEDGRDYLGTAELIADLTLIQTSLREHRGGLFADGRMDRVIRTLSAFGLQLATMDVREHADAHHHALGQLFDRLGEESWRYADMPRDYRQKLLAKELRSRRPLAPTPAPLDAAGQKTLGVFHTVKEAFERFGPEVIESYIISMCQGADDVFAAAVLAREAGLIDLHAGWAKIGIVPLLETTDELKAADVILEGMLADPSYRRLVSLRGDVQEVMLGYSDSSKFGGITTSQWEIHRAQRRLRDVAHRHGVRLRLFHGRGGTVGRGGGPSHDAILAQPWGTLEGEIKVTEQGEVISDKYLIPSLARENLELTVAATLQASALHTAPRQSDEALSRWDAAMDTVSDAAHAAYRRLVEDPDLPAYFFAATPVDQLAELHLGSRPSRRPDSGAGLDGLRAIPWVFGWTQSRQIVPGWFGVGSGLKALREAGLDTVLAEMHGNWHFFRNFIANVEMTLAKTDLRIARHYVDTLVPENLKHVFEVIEAEHALTVSEVLKVTGNDELLGSNPVLQQTFAIRDAYLDPISYLQVALLKRQRDAAERGEEADPLLARALLLTVNGVAAGLRNTG
>NZ_CP011340.1|WP_005316577.1|5115668_5116679_-|stearoyl-CoA-9-desaturase
MTTSPDLLDDVAGTPDSPLPSATRGGDSKRSIEQITLLLFITVPFLALLAAVPLAWGWGVSWLDIGLLVAMYYIGCHGITIGFHRYFTHGSFKAKRPLRIALAIMGSLAVEGPLVRWVADHRKHHKFSDAEGDPHSPWRFGETVPALMKGLWWAHIGWMFDEEQTPQQKYAPDLIKDPALRRISRDFIYWTILSLAIPPLVGGLVTMSWWGAFTAFFWGSLVRVALLHHVTWSINSICHAVGKRPFKSRDRSGNVWWLAVLSCGESWHNLHHADPTSARHGVLRGQLDSSARLIRWFEKAGWAYDVRWPQQSRLDARRDDSGRGETRRKGDAANAA
>NZ_CP011340.1|WP_005316599.1|5129193_5129685_-|hypothetical-protein
MPDHLSTTRFPVAVDAALRDAGWQPGRWDIKQAEHWADTLRAHVSPAGHQHTVFPAVVEAWAEFGGLTVVAPGPGRQHAPAPLRFDPLEGLHLARTLADLGRALDTEISPLGMEGDQQAVLAMDVEGRVYSIDHTGDWYLGADIDQALSTLVTGVQPTRLTPG
>NZ_CP011340.1|WP_037774454.1|5129695_5130202_-|hypothetical-protein
MHTAQPSTSGDPRLSWSADGSGRAPGLRHRRDGILPAVAAALSVRGETLTCTAGKGDQPPVLHPLVQDFLDTLTSGQRERFTGRCPEAILLSRHLTAAETQRSKRAQRKPLTHGEARRALKHAKLTARRIREDGDPLHGSYAPPCRSCTAMLDHFGVRPVAPTAPENG
>NZ_CP011340.1|WP_078951276.1|5130433_5131447_+|cell-wall-assembly-protein-Knr4
MTTGRQGLGAATGPGAGAGTAPPNAAYAGQVVHFPDPVRASRHPRGVRVDDGGYPDFSPYARAAAEIAEPPEGFGVDELRLTDFVSANAALAADGHPLWDTVPAVATPHGWTWHHVPNSRRLELVPVEVKALLRHHGGLTTAAVDHSKRGTRPLQETRPAHFGLPKGAVSVTEQQLRHVEEDLGYRLPGAYRSFLKAAGGSAPVGAALDAELGLLVDQPFFTVREEAAVNDLVYVNKCLRDHLTKDYLGVAFVQGGILALKVRGTDIGSVWFCAYDDARDQDGWHVQERVERLLLPCGEDFDAFLQRLAGNPPELETVANLMVDGGFARAVPVSGEG
>NZ_CP011340.1|WP_053557202.1|5131454_5134235_+|hypothetical-protein
MVTFAQAQERAEEWVNGDVPAYQHREVRVREFDLGFVVWAEDREQGARSDGGRQRLVIARDSGEATLWPGLPVGEVIRRYEEEYGATQDASQAPAPEAPQRIDLNQTSFLLSPPEWLQDAADRMGIPDRRSSPDSPAPAGPSTPAEPAVPAAAADESPAPAAGAFDDQGAVGSNASQSTGSSAASSLSSSPSSAPSSSSSSAASASSSAGSGWPEAGSSQGADASRGGSAWPSAGAVDYEPTASDGVPATPSGGTGWTDTSSAGPDDASVPLPATVFAPPVSLDDSSTPPPVGADAPTALMSGGSQLPRTAIVPGLGAQPQPEPSRQQQTPPPAPGAGAADIADAATSKAVLPPRGARGGTGSTTPPPPGAPGTPGARPGPGATPPPSGPGAPGAPAGGYLPTQLVSQLGPEGPQPPGPPGPPRPPGSTPPPGPPAPPGSTPPPAGGVHQAATMLAGPAQMGPGAPQPPGPPGPPRPPGSTPPPGPPAAPGSTPPPGSTPPPAGGVHHAATMLADPSQMGPGAPQPPGPPGSPAPPGSTPPPAGGVHQAATMLAGPAQMGPGAPQPPGPPGPPGAPGPVPNAPQPPMGGGRPPYGYPQQPTGVPTVGPGYQAVLRYRAPDGSEAQLIRRSAPGTPHPEWQILHELRAMNVPPQQVLELHTELESCELPGAYCARMIRETWPQARITSIASYGRDHASRQQGMQQLLSHQGELHQVADGPARPAPVRSPLPQVPPAPPIPPEGVAQELVGAFGPQGLCRFDQRAVSRQGVPEIVAATLVWAGLPGDFNPFFWAQPAQPVVPTLAELAAQRQVQPASDAGSYLVIGSDFGRAICVQYGTAHIVAVPVESGPGGQPVAPQFVNTGLPEFTRSLALLGRMWRLRFGLTPEQAGRWTVDFQAQLAALDPAALASPESWWSVLLEQMWDGLL
>NZ_CP011340.1|WP_053557203.1|5134709_5136311_-|cation-acetate-symporter
MNGFSSEAQTMSLMAFIAVITVTLLLCVMTGPDRDDLGEFYTGYRSLTPMQSGLAIAGDYISAGTVLGTIGIIALLGYDGLTLTLSTVLSLVLMMFLLAEPLRNAGRFTMGDVFGRRAPGPVVRITAAAVTLTALLPLVIFQLAGAGDLLAVVLGFHADGFKTGSIVFLGLLMITYAAIGGMKGTAFIQIVKTVVLLGAATVIAVLILERFDFSPPALLDAAKEGSGLRDAYLTPGLQFGGDGLDMVSTQLTVVLGAAVLPHITMRMFTARNARAVRRSMSWAVSIVVVTCLLIAVIGFGAAALVGHKELAAGDPQGKTAFLMVSQAVMGPDPNTVETLVFTAVATAIFLTLLASVAGITLACANTLAHDLIAHGLRDARLTDRAEMVIARAAAAGVGLVAIAIAAGARHLNLQALLTLSFCIGASAVAPALVYTLFWRRYTRTGLLATLIVGTVSALVLTAGSNLVSGSPQSVFPDQDFNWFPYTTAGLVSIPLGFLAGWLATVLYDNDAAAQRARYEDLEPTILAGAPTNS
>NZ_CP011340.1|WP_005316612.1|5136307_5136781_-|DUF485-domain-containing-protein
MSYHHQLFPDPPPQPRAPGRHRQEAADPAWGFEPQPWDRPHGPQHHQADDGHVRELQSLGSAYRRLRRVSTLTALGYFVLFLLLSAYAPSSMTGEVSGGLTGGLVLGLVQLPVALAAIAVYERIARRRVDPLVASVRQRAERSAQHGGRQPMGGARA
>NZ_CP011340.1|WP_005316615.1|5136939_5138223_-|MFS-transporter
MGRQRLGRSFGLLWSAYATGTVGTWLAFGAFPLIAIQVLGAGPAAVSALAATGPAAGAMLALPLGQWIEQRRRKPVLIATYAVRFAALLSIPVAYAAGLLTYPQLLAVSVVGAAANIAGTAASGAYLRSLVTPGQLLVAGARFESTTWTATAVGPTLGGAAVTLLGPVATVIANAAGFLLSALAIGAIRDHGTGTAPRATTRPRSTAVLDGWRFILADRDLRPLFWNTVTVNALIMATEPLLAVLLLGDLDWSAWQYGLAFGLPCLGGFLGARLAPRLAARHGHRRVLLVSGVLRAMWPIGLVLVTPGTAGMFVVLAVELVLITCMGVFNPLFATERLERVPAEQVTRVLVAWRATNAWAIAVLTALWGVLAAAIGARAAIGAAGVLLLATPLLLPRRTDLPKPAGESATGTEEAGDLPGIPGKHGI
>NZ_CP011340.1|WP_005316616.1|5138448_5139972_-|MFS-transporter
MGSTGRTERLSGADTGAAAPPGRAPVVAALMLGMALAALDGTVVSTAVPQIVGDLGGFAVFSWLFSGYLLAVTVTLPVYGKLSDTFGRKPVLIAGIVLFLLGSLLCAVAWNMAALIAFRVVQGLGGGALQGTVQTIAADLYPLKERPRIQARLSTVWATAAVAGPAVGGLLAGYADWRWIFLVNLPVGAVALFLVARYFVEPARPAPAVRPRVDWAGALCVFGAGALLLTALVQGGTAWPWLSAPSLALFGGGAVLVAVTVVVERRAAEPIIPGWVWRRRTIAAVNLALGALGLLMVAPTVFLPTYAQSVLGLGPIAAGFVLSVMTLSWPVSAALSDRVYNRIGFRRTAILGITAAMLVLLSFPLLPFPGEPWQPALAMLLLGAALGLFQLPLIVGVQSTVGWSERGTTTASVLFCRQVGQSMGAALFGAVANAVLLSRLGGGSLDSVSHALENPATLTADATEGLRRAVDAAVDHVYVGAAAAAGAALLVLVFVAPKRFPVRTDAE
>NZ_CP011340.1|WP_005316619.1|5140358_5141147_+|ABC-transporter-ATP-binding-protein
MTTAVTTPAPGETGGRTAVAARGRQVVKAYGAGETRVVALDHVDVDIARGQFTAIMGPSGSGKSTLMHCLAGLDTVTSGQIFIDDTEITGLKDKKLTRLRRDRIGFIFQAFNLLPTLNALENITLPMDIAGRKPDAAWLNRVVETVGLGERLRHRPTQLSGGQQQRVAVARALAARPEIIFGDEPTGNLDSRAGAEVLGFLRRSVDELGQTIVMVTHDPVAASYADRVLYLADGRIVDEMLRPTAEAVLDRMKDFDARGRTS
>NZ_CP011340.1|WP_005316621.1|5141143_5143714_+|FtsX-like-permease-family-protein
MTVFRTSLRNFFAHKGRMALSAVAVLLSVAFVSGTLVFTDTMNTTFDKLFAVSSADVTVSPKGAEDTEAPATGRPETLPASLVEQVGKVEGVKSAEGAVSSMSVTVVDSKNKNMGSTSGAPTIAANWTRNDLRSMEIASGHAPRGPTEVMVDADTADKHKLKLGDELRTIAVTGDFTAKITGIASFKVTNPGAAVVFYDTATAQRELLGKEGLFTNVMVVADEGVSDEALKKNLASALEQPYKLQTAKEAADSGREEVGSFLDVMKYAMLGFAGIAFLVGIFLIVNTFSMLVAQRTREIGLMRAIGSSRKQVNRSVLVEALLLGLVGSIAGVAAGVGLAVGLMKMMSAVGMNLSTDDLTVKWTTPVVGMVLGIVVTVLAAYIPARRAGKVSPMAALRDSGMPADGRAGRIRGGIGLVLTGAGAAALLVATQADKASEGSMFLGLGVVLSLIGFVVVGPLLAGGVVRVISALVLRMFGPVGRMAERNALRNPRRTGATGAALMIGLALVACLSVVGSSMVASATEELDKSVGADFIVQSATMGPIVPQAQEALKKTPGLEHVTEYKGVDAKITAPDGTAEDLQLVAADPTYAKDLRRETLAGELSAAYGKDAMSVGSDYAEKRGVKVGDTIKVEFKNGSPADLKVAAITSDDTNVDKGAMYLNITTAAQYVPAEKMPENMIMFAKAVDGQEKEAYTALKKSLAGYPQYKVQNQTDFKQDLKDQIGQLLNIVYGLLALAIIVAILGVVNTLALSVVERTREIGLMRAIGLSRRQLRRMIRLESVVIALFGALLGLGLGMGWGTSAQQLLALEGLGVLEIPWPTIITVFVGSAFVGLFAALVPAFRAGRMNVLNAIATE

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Crispr_ID: NZ_CP011340_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_15

5892479-5892583

Orphan

Consensus_repeat	Method
ATCCCCTGTAGCTCAATTGGCAGAGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_15

>merge|NZ_CP011340|15|5892479-5892583|CRISPRCasFinder
ATCCCCTGTAGCTCAATTGGCAGAGCAGCCGGCTGTTAACCGGCAGGTTACTGGTTCGAGTCCAGTCGGGGGAGCGCGATCCCCTGTAGCTCAATTGGCAGAGCA

>NZ_CP011340|15|14|5892479-5892583|CRISPRCasFinder
ATCCCCTGTAGCTCAATTGGCAGAGCA	GCCGGCTGTTAACCGGCAGGTTACTGGTTCGAGTCCAGTCGGGGGAGCGCG
ATCCCCTGTAGCTCAATTGGCAGAGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_053557332.1\|5906111_5907155_-\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|336482
NZ_CP011340.1\|WP_053557330.1\|5901416_5902763_-\|acetyl-CoA-carboxylase	unknown	unknown	gnl\|CDD\|223895
NZ_CP011340.1\|WP_053557329.1\|5897665_5901364_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173815
NZ_CP011340.1\|WP_037774741.1\|5896624_5897413_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NZ_CP011340.1\|WP_005318040.1\|5892988_5893669_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_037774728.1\|5877354_5878107_+\|sirohydrochlorin-chelatase	unknown	unknown	gnl\|CDD\|225049
NZ_CP011340.1\|WP_053557331.1\|5902755_5904201_-\|acyl-CoA-synthetase	unknown	unknown	gnl\|CDD\|236096
NZ_CP011340.1\|WP_037774745.1\|5907236_5907821_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_037774737.1\|5892006_5892306_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005318030.1\|5886721_5888644_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP011340.1\|WP_053557327.1\|5890490_5891936_-\|sugar-kinase	unknown	unknown	gnl\|CDD\|198375
NZ_CP011340.1\|WP_053557325.1\|5879645_5880917_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|170080
NZ_CP011340.1\|WP_078951288.1\|5904505_5906089_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|226951
NZ_CP011340.1\|WP_037774730.1\|5882916_5883900_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl\|CDD\|378065
NZ_CP011340.1\|WP_037776854.1\|5888640_5890374_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP011340.1\|WP_078951287.1\|5894679_5896632_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366226
NZ_CP011340.1\|WP_005318019.1\|5878153_5879491_+\|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl\|CDD\|235098
NZ_CP011340.1\|WP_005318042.1\|5893763_5894180_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319899
NZ_CP011340.1\|WP_053557326.1\|5880951_5882877_+\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NZ_CP011340.1\|WP_037774733.1\|5883896_5884547_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_053557332.1\|5906111_5907155_-\|rod-shape-determining-protein	gnl\|CDD\|336482	pfam06723, MreB_Mbl, MreB/Mbl protein. This family consists of bacterial MreB and Mbl proteins as well as two related archaeal sequences. MreB is known to be a rod shape-determining protein in bacteria and goes to make up the bacterial cytoskeleton. Genes coding for MreB/Mbl are only found in elongated bacteria, not in coccoid forms. It has been speculated that constituents of the eukaryotic cytoskeleton (tubulin, actin) may have evolved from prokaryotic precursor proteins closely related to today's bacterial proteins FtsZ and MreB/Mbl.	3.06211e-137
NZ_CP011340.1\|WP_053557330.1\|5901416_5902763_-\|acetyl-CoA-carboxylase	gnl\|CDD\|223895	COG0825, AccA, Acetyl-CoA carboxylase alpha subunit [Lipid metabolism].	1.46132e-49
NZ_CP011340.1\|WP_053557329.1\|5897665_5901364_+\|S8-family-serine-peptidase	gnl\|CDD\|173815	cd07490, Peptidases_S8_6, Peptidase S8 family domain, uncharacterized subfamily 6. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	2.85445e-80
NZ_CP011340.1\|WP_037774728.1\|5877354_5878107_+\|sirohydrochlorin-chelatase	gnl\|CDD\|225049	COG2138, COG2138, Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism].	4.82693e-32
NZ_CP011340.1\|WP_053557331.1\|5902755_5904201_-\|acyl-CoA-synthetase	gnl\|CDD\|236096	PRK07787, PRK07787, acyl-CoA synthetase; Validated.	0
NZ_CP011340.1\|WP_037774741.1\|5896624_5897413_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	2.50153e-27
NZ_CP011340.1\|WP_005318030.1\|5886721_5888644_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP011340.1\|WP_053557327.1\|5890490_5891936_-\|sugar-kinase	gnl\|CDD\|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	2.21768e-121
NZ_CP011340.1\|WP_053557325.1\|5879645_5880917_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	4.68231e-73
NZ_CP011340.1\|WP_078951288.1\|5904505_5906089_-\|GAF-domain-containing-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.41913e-12
NZ_CP011340.1\|WP_037774730.1\|5882916_5883900_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl\|CDD\|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	8.43544e-14
NZ_CP011340.1\|WP_037776854.1\|5888640_5890374_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.18675e-164
NZ_CP011340.1\|WP_078951287.1\|5894679_5896632_+\|hypothetical-protein	gnl\|CDD\|366226	pfam00652, Ricin_B_lectin, Ricin-type beta-trefoil lectin domain.	2.71509e-14
NZ_CP011340.1\|WP_005318019.1\|5878153_5879491_+\|deoxyguanosinetriphosphate-triphosphohydrolase	gnl\|CDD\|235098	PRK03007, PRK03007, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0
NZ_CP011340.1\|WP_053557326.1\|5880951_5882877_+\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NZ_CP011340.1\|WP_005318042.1\|5893763_5894180_-\|VOC-family-protein	gnl\|CDD\|319899	cd06588, PhnB_like, Escherichia coli PhnB and similar proteins. The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.	8.50139e-49

>NZ_CP011340.1|WP_037774737.1|5892006_5892306_-|hypothetical-protein
MRYKLTFVAGLAIGFVLGTRAGRERYEQLKKSARQISQNPAVRNAAESAAHNGREAAGKAFHAVSDKVGDRVPDSVSDRVRALRERGGGAEDDWGTTNT
>NZ_CP011340.1|WP_053557327.1|5890490_5891936_-|sugar-kinase
MGIVAGLDSSSGFTRIVVCDADTGAVLRQGCAPHPVEPKATDIDPQAWLLSLGEAATGGLLEGVQAIGVSAQQHGLITLDAQGAPVRPALLGNDKRAQAAAADLIDALGGRQAWAEAVGSVPQSGQPVAKLRWLARAEPDAARRVAAVMQPHDWLVWQLLGRPARRTTDRGGASGTGYWSAGTGAYRTDLVELALGQQCALPEVLGPAEAAGTTPEGLLISAGTGETMAAAFGLGVAVGDAVVSLGASGSVMAVHHEALPDPTGTITSFADATGMHLPVVHTLNAVRALRGSAELLGVTDLSELSALAMKSTPGSSGLVLLPYLEGERTPQLPHTAGTLTGLRRESMKPEHLARASFEGMLCSLADAMDVLRRRGVEVRRVFLLGAAAELPAVQALAPAIFGAQVVVPQPADYAALGAARQAAWALGAAQGTLSPQAPPAWQGAAAQVFEPGEELAVGQAVRQQYGATRDQIHPGAFDATS
>NZ_CP011340.1|WP_037776854.1|5888640_5890374_-|ABC-transporter-ATP-binding-protein
MLIRLLRTYLRPYKKPIGLLVALQLLQTSATLYLPTLNADIIDNGVVKGDTGYILALGALMIGVSVVQVLCNIGAVFYGARTAAALGRDVRADIFGRVQSFSAREVGHFGAPSLITRTTNDVQQVQMLVLMAFTLMVSAPIMCVGGIVMALGQDVPLSAVLLAVVPVLGICVSLIVKRMRPLFRTMQERLDTVNRVLREQITGNRVIRAFVRDEYEKGRFRGANQELTDVSMSTGRLMALMFPTVMTVVNVSSVAVVWFGAQRIDSGAIQIGALTAFLAYLMQIVMAVMMATFMFMMVPRAEVCAERIQEVLDTDSSVVPPLAPVTELRGRGRLEVRGVDFRYPGAEEPVLRGIDLVARPGETTAIIGSTGSGKSTLLGLVPRLFDVTGGEVLVDGVDVRELEPALMARTVGLVPQKPYLFSGTVATNLRYGKPDASDEELWQALETAQAADFVRGLEGGLNAPIAQGGTNVSGGQRQRLAIARTLVQRPEIYLFDDSFSALDYATDAALREALARETSGATVVIVAQRVSTIRDADRIVVLDEGRVVGAGSHHELMEGNETYREIVLSQLTEAEAA
>NZ_CP011340.1|WP_005318030.1|5886721_5888644_-|ABC-transporter-ATP-binding-protein
MSGPGGRMMTGPVERSMDFKGSGKRLLRQLAPERATLWVMLAAGVLSVAFAVVGPKILGRATDLIFAGIVGRQMPEGTSKEQALEGMRRSGDDGLADMLSGVDFVPGEGIDFNAVGEVLLLALAVFVAAGLTMLVATRLSITVINRTVYRMREDVQAKLSRLPLSYFDRAKRGEVLSRATNDIDNISQTLQQTMGQMINSLLTIIGVLAMMFWISPLLALVALVTVPVSVFVAAKVGKRSQPQFVAQWKSTGALNAHIEEMYTGHSLVKVFGRQEESAQGFAEQNEALYEAGFKAQFNSGMMQPLMFFISNLNYVLVAVVGGLRVASGSLSIGDVQAFIQYSRQFSMPLTQVASMANLVQSGVASAERIFELLDAEEQESDAPSAEQLERPRGEVSLEKVSFRYDPDKPLIEDLSLAVEPGHTVAIVGPTGAGKTTLVNLLMRFYEVTGGRIALDGVDIAKMSREDLRSGIGMVLQDTWLFGGTIAENIAYGASREVTREEIEEAARAAHADRFIRTLPDGYDTVIDDEGSGVSAGEKQLITIARAFLSDPVILVLDEATSSVDTRTEVLIQKAMARLAHGRTSFVIAHRLSTIRDADVILVMEDGSIVEQGTHEELLAADGAYARLYSAQFAQAVVEVE
>NZ_CP011340.1|WP_037774733.1|5883896_5884547_-|hypothetical-protein
MPGARPLWETAPVNRLCEYETHVTVRCTDDAARAGLDSWAGAAGLKVTHIVLARGRMVSQPMLTLRGAEDLASQRAAAERLVARLRSGGFEPVRVKIETTPWSPEVRTAEGGYFEHHLKLLLEEDFDREALTALAVRHGAHLSWNARRVASGGRHERFVTQRRRGVPAEEAGAACDALVAELTAEGFDVLGEEREFVLYDSDLSVDDGWIDEGAGR
>NZ_CP011340.1|WP_037774730.1|5882916_5883900_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MNTKWEPTIPGGPDDPAEPDEERRRRRTELPRTLHAGVGPGASRHRLFDPALKHFDSAYRPADSVVAEELRPAWRAARRRALESVVTAVSASGWGDSLVLRGSMLLADRFGDAAREPKDLDFVVVPADWRIEEERTTTMLDEIASAAQRGTEGHGDGPVIDAAGAESEYIWTYERVPGRRMVLPWQAPGLPAGQVQLDFVFNEQLPVEPRSGTVCGVPLRAATLELSLAWKVLWLIDDLYPQGKDLYDAVLLAERCPLGNALLQEVFRLSGNELPSGGQEELRLEHLQDSLRYLDWDHFAQDYPQFADGREQYVRRLLAALGPTFAA
>NZ_CP011340.1|WP_053557326.1|5880951_5882877_+|DNA-primase
MAGRINDDDVKAVRDAVPIDAVVSEYLQLRNAGGGNLKGLCPFHDEKSPSFQVSPSKGLFHCFGCQEGGDTIAFVMKIDHLSFSETVERLAAQAGITLRYEEGGYNPTHQRGERIRLVEAHKIAAQFYVEQLDGPEAEIGRKFLAERGFDQAAAQHFGVGYSPAGWDHLTRYLRGKGFSDKELTLSGLSQEGRRGPIDRFRGRLMWPIRDITGEVVGFGARKLRDDDNGPKYLNTPETAIYKKSQVLYGIDLAKKEIARTSTAVVVEGYTDVMACHLAGVTTAIATCGTSFGGDHIKILRRLLMDNATAEVIFTFDGDAAGQKAALRAFEDDQKFAAETSIAITPGGMDPCELRLAEGDESVQKLVETRTPLFEFAIRQMVRRHNLETPAGRAAALDEAAPIVAGIKNVAIQHESAVQLAGILGILDTQFVVKRVAQLARWARDRGGDRAERGGRGGRGQDRPGTARAYEPQATTGTSGPAINLRSPAHRTERELLKLALQHPELVSPAFDAYGVDEFTAPPYAAVRRTIEEAGGAEQGTRDASGYLARVREAAPDDTVRALVTELAVEAVHARTVDEVYAGVQLVQVRLRAVDRRIRDVQGTMARLGAGGDPERYAAVANELWVLQQYAQSLRNQGAAAL
>NZ_CP011340.1|WP_053557325.1|5879645_5880917_+|FAD-dependent-oxidoreductase
MVDAHRTFVIVGGGLAGAKAAETLRAEGFTGRVILIGDERDHPYERPPLSKAYLTGKDERDSVFVHEPAWYARADIELHLGQTVVSIDRESRSVRLGDGTVVHYDKLLLATGAEPRRLEIPGTGLAGVHHLRRLPHADRLRHVLAALGRDNGHLIIAGAGWIGLEVAAAARGYGAEVTVVEPAPTPLYQVVGPELGQVFAELHRERGVRFHFGVRLTEIIGQDGMVLAARTDDGEEHPAHEILAAIGAAPRTALADAAGLDLADRAEGGGIAVDESLRTSDPDIYAAGDVAAALHPLLGTRLRVEHWANALNGGPAAARAMLGQDVTYDRVPYFFSDQYDLGMEYSGWAPPGSYDQVVLRGDVGRREFIAFWLKDRRVLAGMNVNVWDVTAPIQQLIRTRAEVDAQTLGDPGVALTDLVNLSG
>NZ_CP011340.1|WP_005318019.1|5878153_5879491_+|deoxyguanosinetriphosphate-triphosphohydrolase
MDGTTSTTGTPPGHGTGNGTAPDGYDAAAVERWAGEPDKRPGRTAFQRDRARVLHSSALRRLAGKTQVVTPGTRSLAWDASPRTRLTHSLECAQVGRELGAALGCDPDLVEAACLAHDMGHPPFGHNGEQALNEFAEDCGGFEGNAQSLRLLTRIEPKRFVHAPETGEPVSVGLNLTRAALDAATKYPWPRGGHPTDPGSAKFGVYEDDLPVFEWARLGAPAFRKCLEAQVMDWSDDVAYSVHDFEDGLHAGHIDPNCLMSETERAGIWSVAIGRYVPHDTDPQELSEALDRLVEQAWWPHHYDGSAVAQARLKDATSQLIGRFALAAEGATRQAYGGGLLTRYGAELVVPRATRNECAVLKAVADRYVMQRAEQEALRADQRVVLAELAQALTARAPEGLEPQFRAMFEAAGDDRARKRVIVDQIANLTDASARTLHVRLTARR
>NZ_CP011340.1|WP_037774728.1|5877354_5878107_+|sirohydrochlorin-chelatase
MRPTDRPTLVAVAHGSRDPRALSTVTALLDRVRELRPGLDVRLGHVELNEPLLDDTLRSLGTTPTVLVPLLLSRGHHVKHDLPRAAAAVPGGDIRIARPLGPHPLLAEALAARLAEAGWRPRDGSSRNAGVVLASAGSRDPESAADTRRMADMLGERLGGVPVVPAYASALAPTVPAAVKALTARGRHRIAVASYFAAPGLFAGRSAAAAPWIAAEPLGTHPALARLLLHRYDQARALPRAVRRLELSAA
>NZ_CP011340.1|WP_005318040.1|5892988_5893669_-|hypothetical-protein
MTTVHRLATAPAAPTPGEHIWYASYGSNMDTDRLRYYLTGGRPPGAARSYPGCRDRRPPVRSSPVEFPGTLYFATESPVWQGGRAFYDPATVGVVWGRAHLVTAQQFSDIAAQEMYEVPGKDLDLAAVLTEGRAALGPGRYETLMLLGHLEGIPVLTFTAPWRLPEVTWNKPSAPYLLHLAHGLCGDGTWEPAAVARYLSRCPGAAEAWTLDELTTLIEGLEGPGE
>NZ_CP011340.1|WP_005318042.1|5893763_5894180_-|VOC-family-protein
MSSRLNPYISFAGNAREAMEFYKNVLGGNLRLNTYADIGGETSPSDADKIMHGMLETDRGFTLMGADTPPGMEHKPGNNFSISLSGEDAGELRGYWEKLSADGTVNVPLEKQMWGDTFGMCVDRFGISWMVNINESQG
>NZ_CP011340.1|WP_078951287.1|5894679_5896632_+|hypothetical-protein
MQQPRTPGTVPSSQPGRAPGVSDEELAAALQAGGGGLEVRPMATLLARHWQSVFDYASICATSNKTASMLTAAAFAQLMESLARNAAAGALRPHLLVTVRHIAKVWAGDPTVASVLTGLMNPEGPGENRQLVSRAFHVMPMTAQVLLWHAEVEAEGISIPAGLSGLDPRVASAQLEQAREQFRQACVRVHREYAPTAECRHYNRLLDISLRRGGVLIPDIQVHLSECSYCRFAADQLRHSGGRLGMLLAEALLGGAARSYLDSRPGRRRRAKAAQDAAGPGPRGPRGSGRHSRGGGPRTLRSLALKSRRIAAVGIAPGALTVGAAAAVTGLLVITLASALWQEDDRQAGPSVPSGAVTGTAPPAPGAGAPGPSTPAPDPTATSAGHPAAPLTTRLRNAEAGLCLDITDPAPRAGTEVTMAACSAAPTQKWVYESDGRLRSSAAPALCLNSHGLDGIVVLDGCTSRTAPDAVDVRYDLTIQGQVIPRWNDRLAMVPASTEPGANVVVKVRDESPAQVWRTDASPVGTRQQSGTGQTAPYAEEVNAPPSADHGCAGEPCSAPSAGRGAGAAPGDPGVPSGAGQGAAPDAGRAPEGVPGGEAGDPAEDGLRRVDDPPPDQGAQQSPPPLVTAVVSRNATLPPAGPAAPGPWVR
>NZ_CP011340.1|WP_037774741.1|5896624_5897413_-|VOC-family-protein
MAAHPEGTPCWADAMFPDVEAAKAFYGELLGWTFDEGSPEFGGYTQAFSDGKAVAAVVPRMPGTGGPPAWNLYFATSDVASAAERIRDNGGALLMDPMPVGSFGTMVTAEEPSGVFFSLWQPDAHTGFGKTGEPGAYCWAEVTTRDVERADHFFGSLFPYEAKRMQQDSLDFTVWHLGGEPVAGRLRMTDDFPPDLHPYVNVYFGVEDCDAAIDTVTRLGGTLQRGPLDSAYGRYASVRDPQGAAFSVIDVTTTAGEMPAFT
>NZ_CP011340.1|WP_053557329.1|5897665_5901364_+|S8-family-serine-peptidase
MTRAPARRRARLIAAGVSLVLLPAGQAFATGSDREPVGAAAGTAAARAAQAAHTVTLVTGDKVTVTDLGGGKKSVAVERPKGAVGAVRSEITDGRVTVVPDEARPYLAAGVLDKRLFDVTGLIEQGLAGQDGLPLIVGYAKGAQRTATRGADTVRPLPSVNGAAVEAAASGEFWRAVTSAKSRSAFGAGIAKVWLDGRVEADMAESNAQIGTPTAWEAGLTGKGVKVAVLDTGVDASHSDLKDRVTESRSFIEGEEVADRNGHGTHVSSTVGGSGAASGGLEKGVAPGAELAVGKVLSDEGSGSESQIIAGMEWAAKDIDAKIVSMSLGSQEGSDGTDPMAQAVNTLSAETGALFVVAAGNSGTSGSIGSPGAADAALTIGAVDASDQAAYFTSQGPRFGDNALKPDLSAPGVDILAARSQLTAGEGPYTAMSGTSMATPHVAGVAALLAEKHPDWDGQQLKDALMSTSEQLDASAYALGAGRLDVPGAVGATVTATGSASLGFFRWPYAENEPVTRTVTYTNHSDAPVTLDLALENAPAGVFSLADTTLTVPAHGTAQTSVTGDGTGAPVGNISARIVAKAGERTVARTAVGLVKEEERYTLTVRVLDRDGAATAAHLGVRKLEKGHDPFPATVGDSGTLELRLPPGTYTVSSFLDVRGSNGKGSLGIGFLTDPEITLDRDREITLDGRTLREVRADVGRRTETRQLLMEFDRDANGVSYGGAVQVPPLYDSVFAAPTDKPATGSFEYRTVWRLGKPMLDVSAGGRLLADTRLQAGAAVLDGKQRLDVVDAGAGTTADYTGKDVRGKAVVVRHTGAVDPARLAQNAQDAGAKVLFVTDDAPGRLMAWFGTESYEDRPLHVATVGAADGARLTEAARRHQRLELTGTQYTPFVYDLSEGHPGAVPDRDLVHRPGKRDLAVLDAKFHAAEPADGGEFRYSITDTFPIGFGFQEKIAFPVERTDYVSAGAGQHWHESMSIGPGAIEQRSGTPSYKGGTRSELNWFKPVLHPWLGTGLGWGQTRSGNDLQFNTPGWGDSGPDHTGFGDVWSDDSMTQFTEVYADGELVDRRMSSGAYARDADPAEKTYKVVTDTTLDAERWRLATKGHTEWTVRSAKTPADRRTVLPMLNLGFDVDTDLRGDVRAGKRLGLGIFAEYVKGAADTGRIGGGSLEVSFDDGRTWTAVELDGVRGASAAWEGTVRVPGDARYISVRASAKDDRGGSVQQEIIRAVGVK
>NZ_CP011340.1|WP_053557330.1|5901416_5902763_-|acetyl-CoA-carboxylase
MAERVSAREAIALVSSGFTEQELADLPDAGDGPLGWEGYGAQRDRASRRTGSAESVVYGTALIGGTECVLISFEFGFLGGSLSERAGDRLEAAYALARERRLPLVSLIATGGSRMQEGMIALGQLQRVARASVLLREAGVAHIAVLRDPTTGGGWATLGAGADVILALPGAQVGFAGSRVRPADADPAAYTAEGQLAAGQIDAVVPPGSLRDTLAFWVRALAPATLAAEREPVDPPRALGAGGEPSRTGWDAVRQARGADRPRAEAYLDDYFTRREPLRGDRCGGEDPGMLCGVGLRDGRPVAYVAQGGTATTPAGYRTAARVVRLADRLGLPVLTLIDTPGAANDAEAERSGAGAAIAELFTAVAAARTPLTSLLIGEGGSGGALALAAPGNTWATPASYFSVIAPELAAAILKRSPDQVPHLADQLRLRPQDLVELGVVRGIVGPG
>NZ_CP011340.1|WP_053557331.1|5902755_5904201_-|acyl-CoA-synthetase
MSSLFPALAATATGTDRVALRFGERSLTYAQLRGAAGSLALRIGGAERVALWAGPTLETAVGVVAALLAGVPVVPLNPRTGDRELAHIVADSAPTAVLAAPDDQLPAPLQPLRRVDIAVTGTAGELPPEPAAGSPALIVYTSGTTGPPKGAVLPRRAVAASLDALQDAWQWSSDDVLVHALPLFHVHGLILGVLGPLRRGGEVRHLGRFTAEGVARELGSGGTMLFGVPTMYHRLAEALDDDAELTKALAGARLLVSGSAALPLPDHARIAEATGRRVIERYGMTETLMNTSVRVDGEARPGTVGVPLRGVELRLVDEDGTEIAVRDGETIGEIQVRGDNLFTEYLNRPDATAAAFDGDWFRTGDMAVREPDGYVRIVGRKTTDLIKSGGYKIGAGEIENVLLDHPAVREAAVTGEPDADLGERVVAWIVAADPAAPPSAEELTGHVASQLAPHKRPRTVRFLDVLPRNDMGKIMKRALHG
>NZ_CP011340.1|WP_078951288.1|5904505_5906089_-|GAF-domain-containing-protein
MATGPADPGAGAGAGGPAVPDGPRESDPDTPGGTGRPGQRPVGASRLAALLEAVTGIGTDLDLRTTLQQIVDTAAVLTGARGASLGVVDPERGGLAERFTATAGGAGRSPDPSGGPAAPADAPSAGAEPLRIPIRVDAEMFGDLRLTPPTGDAFSEEDLALLQVLAAQAGIAIGNTRLHETARQRERWIEGAAAVTNALLAGESADDALMTVAEQARNLAEAAAGVVLQPTQEGGMEIVTASTLEDPRDIVGTTIRPGSPVLVQLLGGEPVFIEDAATDPRMTTHVRSRFGPSMMLPLQSGGRLIGTLALPRRRGGRPYTGLERLLATQFASQAALALVLADARHNREQLAVYEDRDRIARDLHDLVVQRLFATEMMLESTRRRAEAGSTDRLLGQAVDELDSTIQEVRTTIFALQQPPADAPATFRGQVLRETRGAAVPLGLLPSVHFSGAVDTLVQEPADRELLAALRGALAAAHRRSDVSSVDVHVDATVRLPDGRQGVRLTVTDDGLDDEGTRGTTLTWYRPL
>NZ_CP011340.1|WP_053557332.1|5906111_5907155_-|rod-shape-determining-protein
MTVSLEQLRRCHVAVDLGAARTRVFVKGVGLVVDEPSVAAVNTRTGALIAVGELAEKMTGRTPGYIRVARPVSGGTVVDIDMAQRMLRHLLGEKLRRQLRRKPRLRAAASTPHDSDPLAQRATVETLVGLGARRVELVDTLIAAAVGCGLPVEQPSATMIMVCGAATTQIAVLSLGSIVTATRIPIGGNAIDNAVIQHLRHRHELMLPSQSVRPLQLALHGNGLTPQGPASTEIHGRDVATGLARSVRVDTAAVREAIHTPLTSVLDGIGKVLRDCPPDLVADLVDRGIMMVGGSALLPGLDQMLHDATGMTVSIAERPDTCTVQGLGAMLEGRIQPLDLDSLATAD
>NZ_CP011340.1|WP_037774745.1|5907236_5907821_-|hypothetical-protein
MTPDARFGPLDFQLVLLRRMADFQPGLAEDARHALGVSLAQQREANRRWQAMLRARGSRGSLSRYRSVLGEPEQVLRRRIGDLECDALLWRLPLWPDLRFEVLAADNGAVWNEWLVRAPGAAGPELRTADDLVPWSCTVDEVARAFPPARPMEGSAPTRWRLSFTLPDGGSRVAEFTWGLLQRLVDRSVGPSGR

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Crispr_ID: NZ_CP011340_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_16

5960624-5960718

Orphan

Consensus_repeat	Method
GCGGATAGCCGTACGACGGCTGCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_16

>merge|NZ_CP011340|16|5960624-5960718|CRISPRCasFinder
GCGGATAGCCGTACGACGGCTGCGGCGGTGCCGGGACGTACGCGGGCGCGGGCTGCGTCACGTCCGACGGCGGATAGCCGTACGACGGCGCGGCC

>NZ_CP011340|16|15|5960624-5960718|CRISPRCasFinder
GCGGATAGCCGTACGACGGCTGCGGC	GGTGCCGGGACGTACGCGGGCGCGGGCTGCGTCACGTCCGACG
GCGGATAGCCGTACGACGGCGCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_037774769.1\|5955509_5955950_+\|DUF3052-domain-containing-protein	unknown	unknown	gnl\|CDD\|378615
NZ_CP011340.1\|WP_005318151.1\|5956061_5956520_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239316
NZ_CP011340.1\|WP_005318152.1\|5956689_5957265_+\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NZ_CP011340.1\|WP_005318141.1\|5949356_5950967_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP011340.1\|WP_005318173.1\|5969244_5969943_-\|DUF4383-domain-containing-protein	unknown	unknown	gnl\|CDD\|379556
NZ_CP011340.1\|WP_078535520.1\|5970226_5971570_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NZ_CP011340.1\|WP_037776871.1\|5951472_5952225_-\|potassium-channel-family-protein	unknown	unknown	gnl\|CDD\|369572
NZ_CP011340.1\|WP_053557342.1\|5961535_5962699_+\|HpcH/HpaI-aldolase/citrate-lyase-family-protein	unknown	unknown	gnl\|CDD\|379744
NZ_CP011340.1\|WP_005318169.1\|5968224_5968869_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP011340.1\|WP_037776874.1\|5962716_5965272_+\|phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|378594
NZ_CP011340.1\|WP_037774767.1\|5951114_5951492_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377188
NZ_CP011340.1\|WP_005318157.1\|5959275_5960019_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226595
NZ_CP011340.1\|WP_053557343.1\|5966345_5966981_-\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP011340.1\|WP_005318154.1\|5957372_5957948_+\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NZ_CP011340.1\|WP_005318168.1\|5967091_5968234_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP011340.1\|WP_005318177.1\|5971710_5972499_-\|DUF4097-family-beta-strand-repeat-protein	unknown	unknown	gnl\|CDD\|372574
NZ_CP011340.1\|WP_005318156.1\|5958019_5959165_+\|DUF475-domain-containing-protein	unknown	unknown	gnl\|CDD\|237583
NZ_CP011340.1\|WP_005318171.1\|5969018_5969234_-\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|274226
NZ_CP011340.1\|WP_053557340.1\|5952327_5955069_-\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	unknown	unknown	gnl\|CDD\|236500
NZ_CP011340.1\|WP_158685193.1\|5973863_5974079_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133458

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_037774769.1\|5955509_5955950_+\|DUF3052-domain-containing-protein	gnl\|CDD\|378615	pfam11253, DUF3052, Protein of unknown function (DUF3052). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.31753e-68
NZ_CP011340.1\|WP_005318151.1\|5956061_5956520_+\|peroxiredoxin	gnl\|CDD\|239316	cd03018, PRX_AhpE_like, Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater similarity to 2-cys PRXs than 1-cys PRXs. PRXs are thiol-specific antioxidant (TSA) proteins that confer a protective role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. The first step of catalysis is the nucleophilic attack by the peroxidatic cysteine on the peroxide leading to the formation of a cysteine sulfenic acid intermediate. The absence of a resolving cysteine suggests that functional AhpE is regenerated by an external reductant. The solution behavior and crystal structure of AhpE show that it forms dimers and octamers.	5.7381e-77
NZ_CP011340.1\|WP_005318152.1\|5956689_5957265_+\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	3.91864e-120
NZ_CP011340.1\|WP_005318141.1\|5949356_5950967_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	7.35272e-72
NZ_CP011340.1\|WP_005318173.1\|5969244_5969943_-\|DUF4383-domain-containing-protein	gnl\|CDD\|379556	pfam14325, DUF4383, Domain of unknown function (DUF4383). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 137 and 164 amino acids in length.	2.90708e-08
NZ_CP011340.1\|WP_078535520.1\|5970226_5971570_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.000228633
NZ_CP011340.1\|WP_037776871.1\|5951472_5952225_-\|potassium-channel-family-protein	gnl\|CDD\|369572	pfam07885, Ion_trans_2, Ion channel. This family includes the two membrane helix type ion channels found in bacteria.	2.15612e-14
NZ_CP011340.1\|WP_053557342.1\|5961535_5962699_+\|HpcH/HpaI-aldolase/citrate-lyase-family-protein	gnl\|CDD\|379744	pfam15617, C-C_Bond_Lyase, C-C_Bond_Lyase of the TIM-Barrel fold. This family of TIM-Barrel fold C-C bond lyase is related to citrate-lyase. These genes are found in the biosynthetic operon, with other enzymatic domains, associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.	5.86084e-171
NZ_CP011340.1\|WP_005318169.1\|5968224_5968869_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.56775e-38
NZ_CP011340.1\|WP_037776874.1\|5962716_5965272_+\|phosphoribosyltransferase	gnl\|CDD\|378594	pfam11202, PRTase_1, Phosphoribosyl transferase (PRTase). This PRTase family is fused to a C-terminal RNA binding Pelota domain, pfam01248. These genes are found in the biosynthetic operon associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.	7.32599e-153
NZ_CP011340.1\|WP_037774767.1\|5951114_5951492_+\|hypothetical-protein	gnl\|CDD\|377188	pfam03995, Inhibitor_I36, Peptidase inhibitor family I36. This domain is currently only found in a small set of S. coelicolor secreted proteins. There are four conserved cysteines that probably form two disulphide bonds. Proteins 2SCK31.15C and SCO3675 also have probable beta-propellers at their C-termini. This family includes Streptomyces nigrescens SmpI, a known peptidase inhibitor of known structure. This protein has a crystallin like fold pfam00030 and is distantly related by sequence. It is not known whether other members of this family are peptidase inhibitors.	0.000149905
NZ_CP011340.1\|WP_005318157.1\|5959275_5960019_+\|hypothetical-protein	gnl\|CDD\|226595	COG4110, COG4110, Uncharacterized protein involved in stress response [General function prediction only].	2.13895e-48
NZ_CP011340.1\|WP_053557343.1\|5966345_5966981_-\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	1.04627e-38
NZ_CP011340.1\|WP_005318154.1\|5957372_5957948_+\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	1.40603e-119
NZ_CP011340.1\|WP_005318168.1\|5967091_5968234_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	5.75635e-40
NZ_CP011340.1\|WP_005318177.1\|5971710_5972499_-\|DUF4097-family-beta-strand-repeat-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	2.12408e-08
NZ_CP011340.1\|WP_005318156.1\|5958019_5959165_+\|DUF475-domain-containing-protein	gnl\|CDD\|237583	PRK14013, PRK14013, hypothetical protein; Provisional.	5.50372e-174
NZ_CP011340.1\|WP_005318171.1\|5969018_5969234_-\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|274226	TIGR02605, CxxC_CxxC_SSSS, putative regulatory protein, FmdB family. This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions].	3.86499e-11
NZ_CP011340.1\|WP_053557340.1\|5952327_5955069_-\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	gnl\|CDD\|236500	PRK09405, aceE, pyruvate dehydrogenase subunit E1; Reviewed.	0
NZ_CP011340.1\|WP_158685193.1\|5973863_5974079_+\|hypothetical-protein	gnl\|CDD\|133458	cd06849, lipoyl_domain, Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.	8.98207e-11

>NZ_CP011340.1|WP_005318157.1|5959275_5960019_+|hypothetical-protein
MAIWDNLWRGRAAQFDSGSAASNSIALTRRNPSVSLTKQGAASGNLRVNLSWRMRSSDIEGRSRQGGRLLSNPLKLFQPDVVQAHTQGVVNVDLDLGCLYELTDGSKGVVQPLGSFFGDLNGPPFVKLSGDDRFGAPSGETIFVNLDHRESIKRLLFFVYIYDQTPAFDRTHAHVTLYPSNGPRVEIELDERAPQARSCAVFSVENTKGDLTVRREVKFVYGFQAELDRLYGWGLQWGRGYKSQSRA
>NZ_CP011340.1|WP_005318156.1|5958019_5959165_+|DUF475-domain-containing-protein
MVLKTFGWSFAVTALGLAFAAWQWGWEAFGIVLILSILEISLSFDNAVVNAGILKKMNAFWQKIFLTIGILIAVFGMRLVFPVVIVAISAKVGPIEAVQLAMDQPDRYEDLVTDAHAAIAAFGGMFLLMIFLDFIFEEREHKWLAWLERPLAKLGKVDMLSVCIALIVLLLTAITFATNAHTSTGHADKSATVLLSGVAGLITYLVVGGLSGYFEDKLEEEEEREHEEEEKAKREGKPVSAVGLAGKAAFFLFLYLEVLDASFSFDGVIGAFAITNHIFWMALGLGIGAMYVRSLTVYLVRQGTLDDYVYLEHGAHYAIGALAVILLITIQHEISELITGFIGVVLIAASFWSSLRRNKALEASEGKPGGPEEKAEVSSGV
>NZ_CP011340.1|WP_005318154.1|5957372_5957948_+|TerD-family-protein
MGVTLAKGGNVSLSKAAPNLTQVLVGLGWDARSTTGAPFDLDASALLCQSGRVLGDEWFVFYNQLKSPDGSVEHTGDNLTGEGDGDDESLLVDLAKVPANVDKIIFPVSIHDADNRGQTFGQVSNAFIRVVNQADGQELARYDLSEDASTETAMIFGELYRYGGEWKFRAVGQGYASGLRGIALDFGVNVS
>NZ_CP011340.1|WP_005318152.1|5956689_5957265_+|TerD-family-protein
MGVSLSKGGNVSLTKAAPNLTAVTVGLGWDVRTTTGTDFDLDASALLTNAEGKVTGDGNFVFFNNLKSSDGSVEHTGDNLTGEGEGDDEQIKVNLAAVPADVDKIVFPVSIYEAESRQQSFGQVRNAFIRVVNQADNNELARYDLSEDASTETAMVFGELYRNGAEWKFRAIGQGYASGLRGIAQDFGVNV
>NZ_CP011340.1|WP_005318151.1|5956061_5956520_+|peroxiredoxin
MAIEVGDKAPEFELKDNHGRTVALSDFRGEKNVVLLFYPFAFTGVCTGELCALRDELPKFVNEETQLLAVSNDSIHTLRVFGEQEGLEYPLLSDFWPHGETSRAYGVFDEEKGCAVRGTFIIDKEGVVRWTVVNGLPDARDLNDYVKALDAL
>NZ_CP011340.1|WP_037774769.1|5955509_5955950_+|DUF3052-domain-containing-protein
MSATADHAEERTNPAARLGFEPGQVVQEIGYDDDVEQELREGIEAATGQELVDEDYDDVADVVVLWFRDEDGDLTDALVDAIGLIDEGGVVWLMTPKTGRDGYVEPSDINEAAQTAGLSQTKSINAGKDWSGSRLVTPKGAKSGKR
>NZ_CP011340.1|WP_053557340.1|5952327_5955069_-|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type
MASGSDRNPIIIGGLPSQVPDFDPEETQEWLDSLDAAVDERGRERARYLMLRLIERAREKRVAVPEMRSTDYVNTIATKDEPFFPGNEEIERKILNATRWNAAVMVSRAQRPGIGVGGHIATFASSASLYDVGFNHFFRGKDDGKGGDQIFFQGHASPGIYARAFLLDRLSEQQLDAFRQEKSKEPYGLSSYPHPRLMPDFWEFPTVSMGLGPLGAIYQARMNRYMEARGIADTSDSHVWAFLGDGEMDEPESLGQLSIAAREGLDNLTFVVNCNLQRLDGPVRGNGKIIQELESQFRGAGWNVIKLVWDRSWDPLLAQDRDGILVNKLNTTPDGQFQTYATETGAYIREHFFGGDQRLRAMVENMTDEQILHLGRGGHDHRKVFAAYTAAKAHKGQPTVILAQTIKGWTLGPNFEGRNATHQMKKLTVDDLKRFRDRLHLPITDQQLESGAPPYYHPGRDSEEIQYMHDHRKACGGYVPTRIVRAKPLQLPEDKTYAAVKKGSGQQSIATTMAFVRLLKDLMRNKEIGKRFVLIAPDEYRTFGMDSFFPSAKIYNPLGQQYEAVDRELLLAYKESPTGQMLHDGISEAGCTASLIAAGSAYATHGEPLIPVYVFYSMFGFQRTGDQFWQMADQLARGFVLGATAGRTTLTGEGLQHADGHSQLLASTNPGCVAYDPAFGFEIAHIVQDGLRRMYGGTPEENEDIFYYLTVYNEPIQHPAEPADVDVEGILKGIHRFKQGEQGAIPAQIMASGVAVPWAIEAQRILAEEWNVRADVWSATSWNELRREAVDVERHNLLHPEEEQRVPYVTRKLSGSEGPFVAVSDWMRSVPDQISRWVPGTYQSLGADGFGFADTRGAARRFFHIDAQSIVLAVLTELAREGKVDRGALKQAVDRYQLLDVSAADPGAAGGDA
>NZ_CP011340.1|WP_037776871.1|5951472_5952225_-|potassium-channel-family-protein
MRWEKRMQTPLLALALVFAVAYTVPIVAPGAPSFVHRACQVAEWVVWGTFAVDYLVRLSLAPGKWLFLRSHPLDLLAVLLPLVQPLRLLRVVSTLLLVGRRARMAPQITLTTYVGGAVVGLMMFGSLAVLQVERDAPGGNIKTLGDAVWWSFTTMTTVGYGDHSPTTGLGRLLAVGLMISGIALLGVVTANIAAWFISRFERDDAEERRQTALLEALTAEVRGLRAEVARLSGTPLSGAPEVPGPSSPRS
>NZ_CP011340.1|WP_037774767.1|5951114_5951492_+|hypothetical-protein
MRKTVTAAALAAAALLPLLLQPPQTAAAAPPRLGACAAGELCLWAENDFRGARSTHELAGTDIESCVPLPPGTSAKALANRTGRPVTTYQSEECAETGEFETYPGGGTWLPRSPYRVRAFKIWEN
>NZ_CP011340.1|WP_005318141.1|5949356_5950967_+|MFS-transporter
MTSQTTVEKAPRDPQDSAPAPVKGLRGHPWLTLFSVAIGVMMVALDGTIVAIANPAIQKDLGASLADVQWITNGYLLALAVALITAGKLGDRFGHRQTFIIGIAGFAAASAAIGLSDSIVLVIAFRVLQGLFGALLMPAALGLLRATFPAEKLNMAIGIWGMVIGASTAGGPILGGVLVEHVSWQSVFFINVPVGILAVVLGLVILKDHRAENAPKSFDILGILLLSGAMFSLIWPLIKAGEWGWGSAGTLGWLAGSVVLFGLFAFWESKVDEPLVPLAMFRSVPLSAGVVLMVLMAFAFMGGLFFVTFFLQGVQEMSPVDSGLRLLPLTGMMIVSSPLAGALITKFGPRLPLVGGMVCTAAAMFGMTTLSEGTGTFAMSLWFALLGLGLAPVMVGATEVIVGNAPMELSGVAGGLQQAAMQVGGALGTAVLGAVMSAKVSAEFADNWKAAGIPAPPDPRLEQAAEFGTVPGELAQAPGMTPELVTTIGDVIHDTFMSGMGLAFTVAGIVAVVAALVAVLTKRGENAEAGAGAAHI
>NZ_CP011340.1|WP_053557342.1|5961535_5962699_+|HpcH/HpaI-aldolase/citrate-lyase-family-protein
MRHFGHIPPAARARLFHQEPCDFGADSAARTLAAALGATLYSPATRPKLADDVLKQAARGVVSMVLCLEDSIDDAEVVDGEANLVRQFADLDARGVEVPLLFIRVRTPEQIPDLVRRLGPSGRLLSGFVLPKFTDERGVPFLEAIVTAEAAGGRRLFAMPVLESPELLHLETRTEALTGIARTVDKYRDRVLALRLGVTDFCSAYGLRRSPDMTAYDVRIVTSVIADVVNVLGRSDGTGFTITGPVWEYFRSQERMFKPQLRRSPFLEGRAEELRTTLIEHDLDGLLREIELDRANGLMGKTCIHPSHVLPVHALSVVSHEEFSDAQDILRPERGGGGVLRSAYTNKMNEVKPHRAWAERTLLRAEVFGVAKEDIGFVELLAAGLTD
>NZ_CP011340.1|WP_037776874.1|5962716_5965272_+|phosphoribosyltransferase
MTTRGEENVVWSGSWVAERLGVSLVGDEGLQELLGLALRRNPKRAHLLVSNVLGKHVPQQPLVVWRAGHDLGLRVRDLLGADECRRAVVLGYAETATGLGHSVADGIGLAPYLHSTRRPVEGVATAGGFEESHSHATSHLLLPEDPDLLGGPGPLVLVDDEFSTGNTVLNTIRDLHARYPRERYVVVALVDMRSAADMGRLDAFAEEIGARVDLVAMASGTVRLPDGVLEKGQALVAAHQQAPPDAGVTPVTAGAGAPRHTRVDLEWPAGVPDGGRHGFTPEHRTALEAALPGMAARISDALRSVPAGRDTGGTRRVLVLGNEELMYAPLRLAAALQQNTHAGTAHDAPAETVCAQARTEVYYSTTTRSPVLAVDDPGYAIRTRLVFPAHDDPADGPGERYAYNVAGAGFDAVVAVVDSTADTDRLHAPDGLLAQLAAHTGHVVLAVVPSYVPALPGHAPDHHAPEGPERPSMLPQPLRGPDFSSYAPEEVGWLLQDLSEVELEAPTEEREEAIQSGGAHYAESLPVEYQPDEQYQQLFEAALTASAARIARAVGTVTDTVLAERTPRPVLVSLARAGTPVGVLMRRWAQHRHGLDLPHYAVSIVRGRGIDANALRWLAENHDPADVVFVDGWTGKGAITRELAEALRDFPGFDPEIAVLADPGGCVRTYGTREDFLIPSACLNSTVSGLISRTVLRADLVGPDDFHGAKFYRELAGSDVSGHFLDTVAARFDEVMPAVDADVKELLSADRTPTWEGWGAVERISEEYGIHDVNLVKPGVGETTRVLLRRVPWKILAGRGAGADLDHVRLLAEQRGVPVEEVDELPYSCVGLIHPKYTRGATGADGRAVAK
>NZ_CP011340.1|WP_053557343.1|5966345_5966981_-|DedA-family-protein
MSSGIESSAPGWVNGLMETLGAPGAGIAIALENLFPPLPSEVILPLAGFAASSGQMGLVAVLLWTTAGSVAGALALYGIGALLGRDRTVAIAARLPLLKVADIERTEAWFARHGAKAVFFGRMIPVFRSLISVPAGVERMPLPLFLTLTTLGSAIWNTVFVLAGHTLGERWEDVTGYVSAYSKAVLVAAVLAVLLFAAVRLLRPGAGSRRG
>NZ_CP011340.1|WP_005318168.1|5967091_5968234_+|sensor-histidine-kinase
MKALAVRGTQYAAGLLLGTLTAVVELIFALLGGLALLLVLAWPHGRRAVRQPLGDVAARLAHLERRRLGRFLGARISSSYSSGHAVRYVVARWPLGLLGGLVVFCVLLGLLYAGYAALGWTVDDIEYPWAVAGTGLLGLFLVFLAGQSVFGLALLEGHLARRLLGPSHHDELERRIAQLATTRAGMMDAVDGERRRIERDLHDGVQQRLVALGMLLGRARRSRDPDRAAQLLLQAHEESRRALAELRDVAWRIYPTVLDEAGLRAALETVAERTPLPVHLTYEVPEPPRSRQVETVAYFVVCETVTNVVKHAGATRITVTLRRDGPRLALRVEDDGVGGADPAGGGLTGLASRVAALDGRFRVDSPAGGPTTVTAELPCV
>NZ_CP011340.1|WP_005318169.1|5968224_5968869_+|response-regulator-transcription-factor
MRLILAEDSTLLREGLVRLLAEEGHEVLAAVGDATALLAAVDASPPDVVIADVRMPPTHTDEGLRAALEIRRNRPRVGVLVLSQYVEKRYATELLTADDGGVGYLLKDRVVQVDEFLDALERVGRGQAAFDPEVVRQLLARSTRGDPLSRLTARERDVLAEMAEGHTNAAIAGRLHVSQSAVEKHINAIFEKLELTGTTGYSRRVLAVLRYLGS
>NZ_CP011340.1|WP_005318171.1|5969018_5969234_-|zinc-ribbon-domain-containing-protein
MPRYEFRCRTCGDTFEVNRPMAESSAPANCPEGHDDTVKLLSAVAVGGTKSAAPAPSGGGGGGCCGGGCCG
>NZ_CP011340.1|WP_005318173.1|5969244_5969943_-|DUF4383-domain-containing-protein
MAAHVLRSRSVGRVRRRITLDEHLPVDHRLSRFYRVGAGIMGLVLVAFGILGLIDRIGFFDTRGDTVAGLNTNGALSVLSIAVGLLLFVGMVIGGNFASTVNMVLGILFILSGFVNLALLDRSFNPLAFRIQNVMFSFVVGVLLMFFGMYGRVSASLPHDNPYWRARHPDQSERELRASRRRAELAAMQPLAPRPSGPGTAAGASPGGVRGTRGIRAAIARRLLSRKPRARR
>NZ_CP011340.1|WP_078535520.1|5970226_5971570_-|hypothetical-protein
MRGDVRSVLALVLVPLPLFAAVAAVLPAAFAGGGGTRRWFGGRGESQRADAQAAKDAAAAAFYELDTAQRDLRISIETITAVDSSPEARRAVEGFAALGRRIDEVSHAYITAVDAHDLDRDDLDVSVAAQARTQLTRAKDELVRVKGELDRFEQGLGTLLDKAETQLARLAPAVERARQALLSASNALDSVRGSGLRADDLAARLARLAPELTKLNEGAGRHGVPETLQRADRVLRDAEAVRTEAERLPERAAEIDKRLVSLRTRAQALTTRSAQVEPVLSELRRRFTAACWQDLQPVPEQAAVSVRQAEEKLREAGKAREEQRWPDATALLGTVRALLNSTDEAVSAAGDRLRRLNAVAKDPQEEIERTRFAIRDAQRLAMTGRNTPDPRHARPLDDSVARLERAVAGLEGRHPDYWHFLTETEAVRRTVQRVVDQIREERGAGAA
>NZ_CP011340.1|WP_005318177.1|5971710_5972499_-|DUF4097-family-beta-strand-repeat-protein
MTSGLRRHHRRAVRGGVAACGVVLLAVGLSGCGSADASEAPVEKKSFALSGKTLTIASDNTDIELVPADVDEVEVTRQVDGWVFLGSGPDASWKMADGKLTLKVKCDAIASDCVARHTVKVPRGTSVTVDDGNGSVTASGFDTALKLRSDNGSVKVTDSSGALELDSENGSVVAEGVTGKNVVATSDNGSVRLELAAVPDRVETHSDNGRVEITLPGAGAPYAVDAKSDNGDVDVAVPTDDNSARVVKARSDNGEVVVRSAN
>NZ_CP011340.1|WP_158685193.1|5973863_5974079_+|hypothetical-protein
MEDGQWDEFQLFVHLSVGAGDRVWKNQPLFDLETVKVRFEVPSPVEGKVLGVYVDDGARVGPNAPIMKISF

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Crispr_ID: NZ_CP011340_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_17

6019467-6019562

Orphan

Consensus_repeat	Method
ACCTACAGCGGCGACCAGGGCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_17

>merge|NZ_CP011340|17|6019467-6019562|CRISPRCasFinder
ACCTACAGCGGCGACCAGGGCGGCTCATGCGTCGAGTGTGCCCCTCTCGGCGGCGCCGCCTGGCGCAAGTCGAGCTACAGCGGCGACCAGGGCGGC

>NZ_CP011340|17|16|6019467-6019562|CRISPRCasFinder
ACCTACAGCGGCGACCAGGGCGGC	TCATGCGTCGAGTGTGCCCCTCTCGGCGGCGCCGCCTGGCGCAAGTCG
AGCTACAGCGGCGACCAGGGCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_053557357.1\|6018619_6019462_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP011340.1\|WP_005318272.1\|6024354_6026277_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NZ_CP011340.1\|WP_053557356.1\|6013573_6013912_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|225209
NZ_CP011340.1\|WP_005318256.1\|6016031_6018056_+\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|379588
NZ_CP011340.1\|WP_005318251.1\|6013974_6014646_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_CP011340.1\|WP_005318247.1\|6012376_6013024_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005318265.1\|6020684_6021929_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP011340.1\|WP_053557786.1\|6026273_6027398_-\|cobalt-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223692
NZ_CP011340.1\|WP_053557360.1\|6028428_6029676_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238362
NZ_CP011340.1\|WP_053557354.1\|6011778_6012243_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP011340.1\|WP_005318263.1\|6019702_6020644_+\|class-A-beta-lactamase	unknown	unknown	gnl\|CDD\|185339
NZ_CP011340.1\|WP_005318280.1\|6031163_6032624_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143457
NZ_CP011340.1\|WP_053557355.1\|6013023_6013548_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_050791570.1\|6014662_6015775_-\|DUF2330-domain-containing-protein	unknown	unknown	gnl\|CDD\|370813
NZ_CP011340.1\|WP_005318268.1\|6022225_6023395_+\|steroid-3-ketoacyl-CoA-thiolase	unknown	unknown	gnl\|CDD\|181145
NZ_CP011340.1\|WP_053557359.1\|6027766_6028429_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_037776885.1\|6009678_6011745_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
NZ_CP011340.1\|WP_078951371.1\|6030018_6031083_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293807
NZ_CP011340.1\|WP_050791571.1\|6018109_6018502_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP011340.1\|WP_053557358.1\|6023506_6024358_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|378961

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_053557357.1\|6018619_6019462_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	3.43226e-07
NZ_CP011340.1\|WP_005318272.1\|6024354_6026277_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	1.82414e-82
NZ_CP011340.1\|WP_053557356.1\|6013573_6013912_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	6.32977e-22
NZ_CP011340.1\|WP_005318256.1\|6016031_6018056_+\|DUF2029-domain-containing-protein	gnl\|CDD\|379588	pfam14378, PAP2_3, PAP2 superfamily.	2.55536e-41
NZ_CP011340.1\|WP_005318251.1\|6013974_6014646_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	1.86755e-54
NZ_CP011340.1\|WP_005318265.1\|6020684_6021929_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	9.65098e-96
NZ_CP011340.1\|WP_053557786.1\|6026273_6027398_-\|cobalt-ABC-transporter-permease	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	4.70009e-10
NZ_CP011340.1\|WP_053557360.1\|6028428_6029676_-\|hypothetical-protein	gnl\|CDD\|238362	cd00688, ISOPREN_C2_like, This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.	2.54524e-10
NZ_CP011340.1\|WP_053557354.1\|6011778_6012243_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.12335e-12
NZ_CP011340.1\|WP_005318263.1\|6019702_6020644_+\|class-A-beta-lactamase	gnl\|CDD\|185339	PRK15442, PRK15442, beta-lactamase TEM; Provisional.	1.12629e-53
NZ_CP011340.1\|WP_050791570.1\|6014662_6015775_-\|DUF2330-domain-containing-protein	gnl\|CDD\|370813	pfam10092, DUF2330, Uncharacterized protein conserved in bacteria (DUF2330). Members of this family of hypothetical bacterial proteins have no known function.	1.09156e-80
NZ_CP011340.1\|WP_005318268.1\|6022225_6023395_+\|steroid-3-ketoacyl-CoA-thiolase	gnl\|CDD\|181145	PRK07850, PRK07850, steroid 3-ketoacyl-CoA thiolase.	0
NZ_CP011340.1\|WP_005318280.1\|6031163_6032624_+\|aldehyde-dehydrogenase	gnl\|CDD\|143457	cd07139, ALDH_AldA-Rv0768, Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like. The Mycobacterium tuberculosis NAD+-dependent, aldehyde dehydrogenase PDB structure, 3B4W, and the Mycobacterium tuberculosis H37Rv aldehyde dehydrogenase AldA (locus Rv0768) sequence, as well as the Rhodococcus rhodochrous ALDH involved in haloalkane catabolism, and other similar sequences, are included in this CD.	0
NZ_CP011340.1\|WP_037776885.1\|6009678_6011745_+\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	9.56553e-96
NZ_CP011340.1\|WP_078951371.1\|6030018_6031083_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.02218e-30
NZ_CP011340.1\|WP_050791571.1\|6018109_6018502_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	1.17949e-15
NZ_CP011340.1\|WP_053557358.1\|6023506_6024358_-\|ECF-transporter-S-component	gnl\|CDD\|378961	pfam12822, ECF_trnsprt, ECF transporter, substrate-specific component. Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.	1.66165e-12

>NZ_CP011340.1|WP_053557357.1|6018619_6019462_+|helix-turn-helix-domain-containing-protein
MSDVRHINALDPGASPLDYYGYELRRHRETAGLTQKQLGAIVNYTGSLVGQVETARKLPTAEFSERVDAALGTGGLLSRLLGLVLRSQLPAWFQQVAELEARATEICTFHTHLVHGLLQTRGYARAVLGAMEVANLDDRTTVRLARQSIFGKQASPVLWAIFGEAALRQEIGGPEVMRTQLRHLLSYTDDPRVNIQVLPFKAGVHAGLEGSFDLFHFTSDPSILYTEGYGTGHPTANPDTVKDCSLRYDHLQAAALSIKDSAQLIRDIMEERYGEHDGVA
>NZ_CP011340.1|WP_050791571.1|6018109_6018502_-|ATP-binding-protein
MRFTAGAHSARHIRRIVRCYLILWKLRELTESVELAVTELLANVVRHVPGGRCGLLILRHPQGVRVEVSDGCAQLPVPQRAGAEDESGRGLALLEAVVDKWGVDSRGGTGKTVWFEVAQVAERADLADDD
>NZ_CP011340.1|WP_005318256.1|6016031_6018056_+|DUF2029-domain-containing-protein
MANAEHSVRGSATADSRIGAARAALWLFAAVLAVRQTAAVLTSPPGERLTDLGTWIGENGVLHVPGSLYDEGRFTGTPFAGLVLKPLARSAEQSLGVAWTFGTLLLVVALGLVAARALPIPVSRRSTLLAAPVAISLLMLSLPVRNSFHLGQTSIIPVLLVLLGCLAVRSERPAGLLIGIGAALQPTVLLFAPLLWFTGRRRAAVTAAGSFAALSALAWAAMPGDSWAYWVHHVAGAGLGESPDSLANQSLHGALLRFGLEGPLEIAVFSLLAAAVVFFGLRRAVRYAQDGQLLLAVALTGCVAVAVSPTAWQHQLLWVLLAVVGRVGRRASDRMLWPVLVVLAITLPGKMLLPNLTVLHPVRDNVLLVAALAAACAVPFLKLDSPYFRRPVPTQYAAPAPARWARVPLLPFWRRVLSRPNLLLELLVIRVGYSVYSHIRAAATGSVGAAEEHARQIHSVEGALGIDIEHWVNQAVVRTEWLEAFFNFYYTSFHFVVPLSILGVLYVRRPSDYRWARASLAFATVLALLGFWLYPLAPPRLMPGMGFIDTVHGPQDLANPDYGAMTAVTNQYAAMPSLHFGWSLWCGLVVLVLAPKLWMKLLALLHPLFTVCAIVATANHWVLDAVGGAAVVGAGFGLTYVLAGRRKLLIPARSVPSARSAHDADDKETAAARV
>NZ_CP011340.1|WP_050791570.1|6014662_6015775_-|DUF2330-domain-containing-protein
MRGNIQEFGVRARLVTVLLAVLVLQLGSLISPAYACGCGAMVVDRNAEISVARESSVIDWDGRTEQIVMRFTVDSNAPEAAWIMPVPNRATVELADGALFDELVRIAAPQHRTRHYFWPRGGDWPFDDTDGAGAPAPGAAAPGVGVVGRERLGDFDVARLTATDPDALGDWLAENGFELPEGLGQDLEPYVDAGWEYVAVKLAPSSEGTTLDGTLDPLRLSFASEKLVYPMRLSRRATTPQSLGLFVLAGHRMEPRDNIGGSEPEVTYAGKVEPRGAVGRLTGGEERFLTALDQHFPEPGRIDGDHELVATAQDTPFRRVIWDDDLLTVAGVPVWLLTVGGGAAVVAVAVVSLLRVRVRRRGTPVPGVAS
>NZ_CP011340.1|WP_005318251.1|6013974_6014646_-|O-methyltransferase
MTQDQWQAVDGYISDLLVAEDEALTEALAASAAAGLPAINVAPNQGKLLHLLAQTQGARTALEIGTLGGYSTIWLARALPEDGRLISLEYDPAHAEVARANIARAGLAKIAEVRTGAALETLPRIAAEPGAGPFDLVFIDADKRNNPRYVEWALRLTRPGSLIIVDNVVRGGGVVDATSEDPSILGTREMFELVAREPRLDATALQTVGVKGYDGLLVARVIA
>NZ_CP011340.1|WP_053557356.1|6013573_6013912_-|antibiotic-biosynthesis-monooxygenase
MSIVKINVLTVPDEQREVLEKRFASRAGAVESSDGFEWFELLRPVEGTDQYLVYTRWRDEASFQAWMEGPMKAAHQGGATQDGGGERPKPAATGSTVWSFEVVQQAAPKSRS
>NZ_CP011340.1|WP_053557355.1|6013023_6013548_+|hypothetical-protein
MPHPNHQESPRTAVPPGTAGDAGDLGVPAAPVGRDGKDDVRAPGLRAGRGAAHGARPGPVAEPLKPAVDPAGTPLTAPGAGDAEPRAARLLPQDECERLEHGLRDALTGFVDSPRHAVEEAAGVLEDAVDRITASLAEHSRTLRHSADAGAGDTEELRRTLQAYREVTERLLRV
>NZ_CP011340.1|WP_005318247.1|6012376_6013024_+|hypothetical-protein
MSTLTTVLIVAAVIVVLLITAGALYARSRGGHAGGRRALRRRFGPEYDRVLARHDGDTKAADRDLHDRVRRYGDLTAQPLAPGVRAQYDAAWAAVQERFVDDPRGAVADADQLLGRIAADRGFPAAGRYEEQLAALSVHHPRHVEGYRRVHRAARAGSEASTEHLREAMVHARELFDDLVADRSVDHGRHRPGGTADRSHGRGRGHLLHPRGSGV
>NZ_CP011340.1|WP_053557354.1|6011778_6012243_-|GNAT-family-N-acetyltransferase
MAPEPFDSPDATALRRAYYHDVASRYWGRPATVEEVDEGLTGDGAELLTPPTGRFVVGRYGGEAAACGGVLMLDQERAELTQVFLLHDFRGRKGASLLMETLEHEARALGARRMVLNTRLDLVEARALYARHGYVEIPAYCTGPYMDIWYGKDL
>NZ_CP011340.1|WP_037776885.1|6009678_6011745_+|MFS-transporter
MAQEVSSAQVGPAPGEGHDRRTVLVAIGALLLGMLLAALDQTIVATALPTIVSELGGMDHLSWVVTAYMLAATAATPLWGKLGDQYGRKKLFQTAIVIFLVGSALCGISQNMPQLIAFRAVQGLGGGGLMVLSMAIVGDLVSPRERGKYQGLFGAVFGATSVLGPLLGGFFTEHLSWRWVFYINLPIGVVALLVIAAVLHIPVRRTRHTIDYLGTFLIASVATCLVLVASLGGTTWAWGSARIIGLAVLGAVLLVAFVAVERKAAEPVLPLKLFRIRTFTLVAVISFIIGFAMFGAMTYLPTFLQVVQGISPTMSGVHMLPMVFGLLLTSTASGQIVSRTGRWKVFPIAGTAVTALGLLLLHQLEANSSTWQMSLYFFVFGAGLGLVMQVLVLVVQNAVGYEDLGVATSGATFFRSIGASFGVAIFGTIFTNRLEHKLTDALAGQRVPPGAGAAELAADPRAIAELPADLRPSVLNAYSTAITDVFLYALPVVALAFLIAWFLKEDKLRGSVTAPDHSETLASNPVERSSYDEVARALSVLGSREGRRHIYEKITARAGYDLLPASSWLLLRMKRHGVVEPARLAETTPVPLRAITEASREVEGRGLARREGLDLMLTESGEEAAVRLAQAREESLAELLGDWWGPERPTDLVQLVHELNAELCGSDAERPHSPESHRDHEYPKGHAV
>NZ_CP011340.1|WP_005318263.1|6019702_6020644_+|class-A-beta-lactamase
MTSSGPAVTRRALLGAAALLPLAGCATNKPVSPSPTGTPSSSVASSPPADRHDRLVELERKYDARLGMYALATGSGKVIAHRADERFAFCSTFKGLAAAAVLDRNPLSHLDTLVRYTEADLLKNASITPRHVSTGMTIRGLCDAAVRHSDGTAGNLLLRDLGGPAELTAYVRGLGDTVTRMDRIEPLITEATPGDPRDTTSPRAFGSDYREIVLGDALPPEKRAFLRDLLERNATGAGAARVRAGVPKGWAVADKTGTGSYGTLNDIAVVWPPGSAPIVISIMSSKATEDAAYDQALIAEAAAYAVAVLAPRG
>NZ_CP011340.1|WP_005318265.1|6020684_6021929_-|cytochrome-P450
MSCPHLPPGFDFTDPDLLQARVPHPEFAEMRRTAPVWWCEQPAGISGFDDEGYWVVTRHADVRHVSTHPELFSSWTNTAVIRFNESISRDQIEVQKLIMLNMDPPEHTRVRQIVQRGFTPRAVRSLEAALRRRARSIVETARSGARPDGSFDFVTNIAVELPLQAIAELIGVPQEDRSKIFDWSNKMAAYDDPEYAITEEVGTEAAMEIVSYAMNLAAARKECPAGDIVSRLVAAEDEGNLSSDEFGFFVILLAVAGNETTRNAISHGMHAFLTHPEQWELYKRLRPDTTAEEIVRWATPVVSFQRTATQDVVLGGARIKKGDRVGLFYSSANNDPTVFDHPERFDITRDPNPHLGFGGGGPHFCLGKSLAVMEINLIFDAIADALPDLRLAGDPRRLRSAWLNGIKELRVTTG
>NZ_CP011340.1|WP_005318268.1|6022225_6023395_+|steroid-3-ketoacyl-CoA-thiolase
MAAEPVIVEAVRTPIGKRGGLLANLHPAYLLGETYRELLARTGIPADCVEQIVGGTVTHAGEQSMNPARTAWLTVGLPYETAATTVDCQCGSSQQAGHMVANMISAGVIDIGISCGVEAMSRVPLGSGSKHGPGKPFPDEWNVDLPNQFEAAERIARRRGLSREDVDRLGLLSQQRAAVAWSEERFKRETYAVQVPTTEEEQAAGQGMWRLVDRDEGLRDTSAEALAGLKPVMPTAVHTAGNSSQISDGAAALMWASKRMARALKLKPRARIVAQALVGADPHYHLDGPIDATRAVLGRAGMSLKDIDVVEINEAFASVVLSWAQVFDQDLDKVNVNGGGIALGHPVGATGARLVTTALHELERQDKEFALIAMCAGGAQATGTIIQRI
>NZ_CP011340.1|WP_053557358.1|6023506_6024358_-|ECF-transporter-S-component
MSSPAPPTPRVTRPVRLGPRSIAALVLISAIGVVFFGWPLLAGGSSGLAAHSGDAPWLFGALLPLLVAVVVATIADSGMDAKAVAMLGVLAAVGAALRPLGAGTAGLEPMFFLMVLSGRVLGPGFGFVLGAVTMFASALLTGGVGPWMPFQMLSMGWFTMGAGLLPGAERLRGRAELLMLAVYGALAAFAYGTVMNLYGWTIISGLSSGISFHPGAPVHENLVRFLAYCAATSLGWDLGRAVLTVVLTFTLGATLLKALRRATRRAAFEAPATFEAPGGGPRP
>NZ_CP011340.1|WP_005318272.1|6024354_6026277_-|ABC-transporter-ATP-binding-protein
MIRFENVTVTYEGAAAPTLENIDLTVPEGELVLLVGPSGVGKSTLLGAVSGLVPHFTGGTLRGRVTVCGRDTRTHKPRELADVVGTVGQDPLAHFVTDTVEDELAYGMESLGLAPAVMRRRVEETLDLLGLVELRDRPIATLSGGQQQRVAIGSVLTTHPKVLVLDEPTSALDPAAAEEVLAVLQRLVHDLGTTVLMAEHRLERVVQYADRVVLLPAPGAAPVVGDPATVMADSPVHPPVVTLARLAGWSPVPLSIRDARRRAGALRERLAGTGAMPPRPDASGSPYGPAAVGGGTSHAARRRGSAPSEAGVVGGAGSAERMPAGPAIEGTAEGRTGSGACPGSRKGRGGEQAPRGGGPTRHRPTRRLLARLLRTAPPAEPAAGSPTHLVATTTGLAVRRARVEALRRVDLAIAPGETVALMGRNGAGKSTLLNALVGMIEPTAGTVTVGGRTPHRTPPRELIRQVGLVPQEPRDLLYADTVAAECAAADSDAEAAPGTCRALVTELLPGVPDATHPRDLSEGQRLALALAIVLTGRPPLLLLDEPTRGLDYAAKARLVAVLKGLAGAGHAIVLATHDVELAAELAHRVVILAGGEVVADGPTADVVVSSPAFAPQVAKILAPQPWLTVSQVEAALEAAP
>NZ_CP011340.1|WP_053557786.1|6026273_6027398_-|cobalt-ABC-transporter-permease
MLNALNALRAPAVSRSNALHAGAWWLWALGLAVAASRTTNPLLLGLLVGVAGYVVAARRTDAPWARSYGAFVKLGLLVIGIRVAFSVALGSPIAGTHVLFTLPEVPMPGWADGVRIGGRVFAEQIVFALYDGAKLATLLICVGAANALANPARLLKSLPGALYEAGVAVVVAMTFAPNMVADVLRLRTARRLRGRPTGGVRAVAQIGLPVLEGALERSVAVAASMDARGYGRTAQVPPAVRHTTTALTLGGLLGVCAGSYGLLAAEGARFGVPLLVAGLAAAAGGLWLGGRRSVRSRYRPDRWGVRSWLVAGSGAAVAALMVRAATVPGSEALHPGVVPLTAPELPLWPALSVLIGLLPAFVAPVPVGAKESTR
>NZ_CP011340.1|WP_053557359.1|6027766_6028429_-|hypothetical-protein
MRARLLSLLGLCALLLVAVAAPAQAAGYRYWSFWKSSGGEWTYATEGPATARPADGSVHGFRFSVSEDSGDAATPRTAPDFATICAGTPAKDGTKRIALVIDFGTAPDAPQGETPPARRTACARVAPAATTAEALAQVAKPLRYNSEALLCGIAGYPASSCGDQALPADLPTPGTGSRSAVVTTKEPAGGDGPSVGVYTGIAAVLTLAGAAAWRSRRTPR
>NZ_CP011340.1|WP_053557360.1|6028428_6029676_-|hypothetical-protein
MTTVRRGAAALVVSAVLGLSAAPAAFAAPSAPSPTPSVELPAGLYGKGDPTYDGVWRQSLALLAQDTAGVKPADAAVAFLTGQQCAGGGFPSYRADTAKDCDAKLPLDTNAGAAAVQALAALGGQDAVVDKTVGWLKSVQNEDGGWGYNPGGASDANSTSVVIGALAAAGEQPAAARSKGGKTPYDALLTFAKPCGGQDGGAFVYQVASPGIVADSTAAAVIAAHGKGLAATGGGTKDAKGTACEKATDLEGAAHNGAAYLANGLAEKGHFDTPPMPGAEDSAPAPDFGNTADAIVALSTQGLAEQAKKPLSWLQQNSAAWAEQNGPAAYAQLIFAARAAGADPRSFGGQDLVAALNATGPAPQAAASPSASAKSEKDSGDSSDSSSSTWWIVGVFFVAAVGVGFLFSGRRKNQS
>NZ_CP011340.1|WP_078951371.1|6030018_6031083_-|MBL-fold-metallo-hydrolase
MGPTTDEAAAGHVTDHGGGVRSLRVPIPDNPLGHTLVHLLDTDRGPVLVDTGWDDPTAWDTLSAGLAACGTSPAEIHGVVVTHHHPDHHGLSGRVREASGAWIAMHAADATVVRRTREAEPGLWLDYLTGKLTRAGAPEAHIAPLRAARAAGGGGALPGLRPALPDREIVPGELLDLAGRRLRAVWTPGHTPGHVCLHLEETHPAGRPGNGRLFSGDHLLPGITPHIGLYEDPDDATVTDPLGDYLDSLERVGRLAPAEVLPAHQHAFTGAQDRVRELLAHHEQRLTGLLALLVRPLTPWQVAERMEWNRPWEQIPYGSRNIAVSEAEAHLRRLVKLGRAETATGGEPVRYVAV
>NZ_CP011340.1|WP_005318280.1|6031163_6032624_+|aldehyde-dehydrogenase
MTELVEHGELFIGGELTAPLGTEVIEVISPHSEQVLGRVPHASRADVDRAVAAARRAFDEGPWPRATLEERIEVVGRIKDAIAVRHEEIARSISAQNGSPYSWSVLAQALGAMMVWDSAISVARDFTHEERRDGVLGPILVRREPVGVVAAVVPWNVPQFTAAAKLAPALLAGCTVVLKPSPETPLDSYILGEIAREAGLPEGVLSILPAGREVSEYLVGHKGVDKVSFTGSVEAGRRVMEVASRNLTRVTLELGGKSAAVILPDADLATAVAGIVPAAWMNNGQACVAQTRILAPRSRYDEIAEAFAAAASALVVGDPLDAATQVGPLVAERQRRRSLDYIRIGQEEGAKILCGGGRPAGLERGWYVEPTLFGGVDNSMRIAREEIFGPVICLLPYGDEDEAAAIADDSDYGLSGSVWTSDVEHGIDFARRVRTGTYNVNTFSLDMLGPFGGYKNSGVGREFGPEGYGEFLEHKMIHLPAGHGSH

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Crispr_ID: NZ_CP011340_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_18

6162773-6162988

Orphan

Consensus_repeat	Method
CGCCGCCGTCCTGGCCGTCGTTCT	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP011340_18

>merge|NZ_CP011340|18|6162773-6162988|CRISPRCasFinder
CGTTGCCGGCCTGGCCGCCGTTGTCGTTGTTGCCGTCGTTCCCGTTGTTGTCCCCGTTGTCGCCGTCGTTGTTGTCGCCGTCACCGTTGTCGTCCTGGCCGCCGCCGTCCTGGCCGCCGTCCTGGTTCTGGTCCTGGTCGCCGCCGTCCTGGCCGTCGTTCTGGCCGTCGTTCTGCCCGCCGTTCTGGTCACCGCCGCCGTCCTGGCCGTCGTTGT

>NZ_CP011340|18|17|6162773-6162988|CRISPRCasFinder
CGTTGCCGGCCTGGCCGCCGTTGT	CGTTGTTGCCGTCGTTCCCGTTGT
TGTCCCCGTTGTCGCCGTCGTTGT	TGTCGCCGTCACCGTTGTCGTCCTGGC
CGCCGCCGTCCTGGCCGCCGTCCT	GGTTCTGGTCCTGGT
CGCCGCCGTCCTGGCCGTCGTTCT	GGCCGTCGTTCTGCCCGCCGTTCTGGTCAC
CGCCGCCGTCCTGGCCGTCGTTGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_005318455.1\|6157057_6157858_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NZ_CP011340.1\|WP_005318458.1\|6161121_6161697_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|164795
NZ_CP011340.1\|WP_078951372.1\|6154980_6156888_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_053557378.1\|6147277_6147709_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319924
NZ_CP011340.1\|WP_053557382.1\|6170357_6171377_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|177922
NZ_CP011340.1\|WP_005318469.1\|6169440_6169977_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|294013
NZ_CP011340.1\|WP_037774864.1\|6172977_6173673_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_037774862.1\|6171862_6172783_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP011340.1\|WP_005318448.1\|6152314_6153394_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP011340.1\|WP_053557379.1\|6148050_6151038_+\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	unknown	unknown	gnl\|CDD\|237613
NZ_CP011340.1\|WP_078535525.1\|6153472_6153958_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
NZ_CP011340.1\|WP_005318464.1\|6164275_6165544_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP011340.1\|WP_053557380.1\|6154071_6154812_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP011340.1\|WP_053557790.1\|6166269_6167253_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187575
NZ_CP011340.1\|WP_005318467.1\|6168013_6169444_+\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|225723
NZ_CP011340.1\|WP_050791754.1\|6167445_6167955_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005318462.1\|6163628_6164291_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP011340.1\|WP_053557381.1\|6157884_6161019_-\|alpha-N-acetylglucosaminidase	unknown	unknown	gnl\|CDD\|377453
NZ_CP011340.1\|WP_005318447.1\|6151346_6152240_-\|inositol-phosphorylceramide-synthase	unknown	unknown	gnl\|CDD\|379588
NZ_CP011340.1\|WP_037774869.1\|6174308_6174671_-\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239332

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_005318455.1\|6157057_6157858_-\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	9.63801e-70
NZ_CP011340.1\|WP_005318458.1\|6161121_6161697_+\|hypothetical-protein	gnl\|CDD\|164795	PHA00370, III, attachment protein.	0.00241744
NZ_CP011340.1\|WP_053557378.1\|6147277_6147709_-\|glyoxalase	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.26723e-22
NZ_CP011340.1\|WP_053557382.1\|6170357_6171377_-\|glutamine-synthetase	gnl\|CDD\|177922	PLN02284, PLN02284, glutamine synthetase.	1.0304e-164
NZ_CP011340.1\|WP_005318469.1\|6169440_6169977_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|294013	cd00383, trans_reg_C, DNA-binding effector domain of two-component system response regulators. Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.	1.84293e-32
NZ_CP011340.1\|WP_037774862.1\|6171862_6172783_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.43522e-25
NZ_CP011340.1\|WP_005318448.1\|6152314_6153394_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.1122e-93
NZ_CP011340.1\|WP_053557379.1\|6148050_6151038_+\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	gnl\|CDD\|237613	PRK14109, PRK14109, bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase.	0
NZ_CP011340.1\|WP_078535525.1\|6153472_6153958_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.96454e-05
NZ_CP011340.1\|WP_005318464.1\|6164275_6165544_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.37621e-42
NZ_CP011340.1\|WP_053557380.1\|6154071_6154812_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.85227e-12
NZ_CP011340.1\|WP_053557790.1\|6166269_6167253_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187575	cd05265, SDR_a1, atypical (a) SDRs, subgroup 1. Atypical SDRs in this subgroup are poorly defined and have been identified putatively as isoflavones reductase, sugar dehydratase, mRNA binding protein etc. Atypical SDRs are distinct from classical SDRs. Members of this subgroup retain the canonical active site triad (though not the upstream Asn found in most SDRs) but have an unusual putative glycine-rich NAD(P)-binding motif, GGXXXXG, in the usual location. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.0599e-71
NZ_CP011340.1\|WP_005318467.1\|6168013_6169444_+\|PepSY-domain-containing-protein	gnl\|CDD\|225723	COG3182, PiuB, Uncharacterized iron-regulated membrane protein [Function unknown].	6.23869e-67
NZ_CP011340.1\|WP_005318462.1\|6163628_6164291_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.66919e-38
NZ_CP011340.1\|WP_053557381.1\|6157884_6161019_-\|alpha-N-acetylglucosaminidase	gnl\|CDD\|377453	pfam05089, NAGLU, Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold.	2.12448e-134
NZ_CP011340.1\|WP_005318447.1\|6151346_6152240_-\|inositol-phosphorylceramide-synthase	gnl\|CDD\|379588	pfam14378, PAP2_3, PAP2 superfamily.	2.8733e-45
NZ_CP011340.1\|WP_037774869.1\|6174308_6174671_-\|arsenate-reductase-family-protein	gnl\|CDD\|239332	cd03034, ArsC_ArsC, Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.	5.69115e-42

>NZ_CP011340.1|WP_005318458.1|6161121_6161697_+|hypothetical-protein
MRTSTSTSTWRAARTGLAVVVLALAAACGSGGDDDGRVGPDKGAKEQRTATGSLEDLARQADCEPNIQTDADELRQANCRTADGRYILATFATDRGQREWINEANDYGGTYLVGRKWVAVGDEKVVAALRERLGGTVETGAQHGSGHEGGDSGSGGDGDGGHEGHDGGEGHDGGGESGGSAGEGHEGHQGS
>NZ_CP011340.1|WP_053557381.1|6157884_6161019_-|alpha-N-acetylglucosaminidase
MNELSRRTLLGTAGAVGAGAVLAAHTPAAAALPRPASPPAAPGAGAEDAFRTGPAAAALHRLLPDHADQVRLTALTGPERFRVTGSAGRIEVAGTGPGVLLTGVHWYLKYVCRAHISWSGSQLDLPRRLPAVRRPIERKATVRHRFAYNDTHDGYTAPYADWPRWERLIDVLALHGCNEVLVTPGQEAVYHRLLTDFGYSDEEARTWLPAPSHQPWWLLQNMSGFGGPMSAALIERRTELGRRITDRLRELGMHPVLPGYFGTVPDDFPGHNPGSDARVIPQGTWGGGMRRPDWLDPRTQAFSDVAAAFYRHQGELFGDVSHFKMDLLHEGGTAGDVPVPDAARAVETSLQTARPGATWVILGWQSNPRPVMLDSIDTSRVLIVDGLSDLDTVTDREADWGGAPYAFGTIPNFGGRTTIGANTDRWTEKFTAWRDKPGSALVGTAYMPEAAERDPAALELFSELAWREEKIDREAWFAEYAQIRYGGVDHSAREAFAALAATAYKLTSTDGRPYDSLFSRRPSLTTAIGTAFDPAGFDRAFAALLAVRAPLRDSDAYRHDLTDVARQALANRSRTLQLALRAAYRNKDVATFRAVSALWLKVMRLSDTMAGCHRQFLLGPWLEDAKRLATSPEEAVQLERTARTLITTWADRPTANSLSNYANRDWQGLMADVHVPQWEAFLTEQADAMAAGRAPKSFDWYPQEEAWTQERHTYPVRPTGDAYSTALRVFDTLARAPYQGVVTVEVEPPAFTPGSTGTVTAVFRNINGLSGTGRVDFALAGLDAAPEGPSALEGVPAAGSGEVSWRVTAPGDPLTEPLRPMPYELTTQYGPLGEDRVTTTQPGNVYIAAPLDPAWRTFTSNGAVFGQLGDRFAINGAGNDLWRGTTQFGTAYLPGAFTEGASIVLRVDAQDNTGTWARAGIMVRNSLATPGDLGFLNLAVTPGQGVALSYDSNGDGTLDNYGRITGIRAPVLLRLTKNAGTSFTGACSTDGGATWRAVATVAVPGTAATQDAGIFMSATNGGSGVRGTVRFSGWSLTGGVAAGG
>NZ_CP011340.1|WP_005318455.1|6157057_6157858_-|tyrosine-protein-phosphatase
MNAIPSTTVANLRDLGGTPLPGGRSVRSGLLFRSGQLDRMDTASDPAVAALGIRTVVDFRTRAEREARPDRLPEGGRLLLADVMADQVAAGRMPAAARLRRLLADPAVAEQELGDGRGRELFGAIYRGFVTTDSARASYRAFLNAVADPDPGPLLFHCTAGKDRTGWAATIVLTLLGATPKTVEAEYMSVNTAVREAFAPLVEGYTLQGGQPETALSIIGVVPDYLAAALDEVDARFGSMEKYVQEGLGVTPAALERIRGRLVVQG
>NZ_CP011340.1|WP_078951372.1|6154980_6156888_-|hypothetical-protein
MEVGQAEAALVEHYPRLVRIAYLVLPSSLGQGRRVLTAHAVVQRSLPRGDAAATPVPAVPPARRPEGAGDPGYTYVRDRVLRQALDAARPLRRRGLPRRAQFPPLLPHVWGLRVFPRSGGADELALDQRLSALSGPARAAYVLRHLEKLSDRDVRQALTAAGAADPDSALADADADGVADGRRGAEVLRSPEFDACSLQVRPTDLMRRRRHARAAVVAAAALAVCGTLLLLPGDGNGGGGDPPSARVPAVEAALDPDRLVRVAPAAWRESARRDFSVWPARGSLSFDHALLRRSLTAWAAPGESVRVTSTPGTPSGPPMGPPQLLFAGQVGAARVVVLHDGLRIVRYAETTGAPGAARDASLDFARTDGADAAGSGALVAGRSRDNIRYLTAPWVRAVSVRDLLDPAGRPRPVRRDASGLTERLPSPVQQHACRAWQGLELSDGRTLTLVTDLGELTPAQLTYGPPGAPQEVTGGAARASWARTACLLPGVRAHGVRSVNLWQYARQPLPEANGTAGWVCTRAETWRGTGSRVMAQFQPPAERPGAPGTVVARAEDSPACGVREPRVLAGVLWQSRAGQWYVLAAGSSQLVSVGVAGSGVEGGATGNVVAVRSREGSRPELNGLLADGTRVHPLR
>NZ_CP011340.1|WP_053557380.1|6154071_6154812_-|TetR/AcrR-family-transcriptional-regulator
MTTGVRRRMGVEERRQQLIGVALELFSHRSPDDVSIDEIAAAAGISRPLVYHYFPGKQSLYEAALRRAADELAARFMEPREGPLGARLLRVMGRFFDFVDEHGPGFSALMRGGPAVGSSTANAMIDEVRQAAHDQILVHLGIADPSPRLELVVRSWVSLAESTALIWLDGRRVPRAELELQLVHDFAALAAVSAAHDEEMAALLVRILADEPMDGPFGDLMGRLAALLPAITRTAPAAHVPAQRLR
>NZ_CP011340.1|WP_078535525.1|6153472_6153958_-|GNAT-family-N-acetyltransferase
MLRHGIDQWKPGDKDADHFRRRIAEGEVWLLEAGGRIAGAYELWWDDLPAWGVRPPVAGYVHRLMTARTHAPAGSGRAMLAHAERRIAAAGRQLARLDCLSRNPRLRTYYEGAGYEVVGEEPAKRAADGSSYGVLLLEKRLPPATPAPNSLTPGARWEEAR
>NZ_CP011340.1|WP_005318448.1|6152314_6153394_-|LacI-family-DNA-binding-transcriptional-regulator
MTAPARLADIATQAGVSEATVSRVLNGRPGVAATTRQSVLAALDVLGYERPVRLRLRSAGLVGLITPGLDNPIFPALAQVVGQALTRQGYTPVLATQTPGGSTEDELTEMLVERGVSGIIFVSGLHADTTADMDRYDRLRAKGVPFVLVDGFAPGVRAPFISADDRGAMQLAVTHLASLGHTRIGLAVGPRRFVPVLRKIEGFRLALHEQLGIPPESSAELIEHSLYTLEGGQAAAATLMDRGCTAVVCASDMMALGAIRAARHRGLEVPDDISVVGFDDSPLIAFTDPPLTTVRKPVQAMGQASVRALLEETGDSHSASAPDRPRAPVHGEFVFMPELVVRGSTASGPGGRPGDTPRP
>NZ_CP011340.1|WP_005318447.1|6151346_6152240_-|inositol-phosphorylceramide-synthase
MGEATVKTLEGRAATPSPIVEDEAAESPVRSRTRPPRTPARPSIWFEVMLIAVSYWTYSLIRNAVPEQKSQAMRNADWIWQLEKTLGIAVEESVNHAVNSVTWLIVSMNYYYATLHFVVTISVLVWLYRVHPGRYAAARLVLFATTGVALVGYYLYPLAPPRLMNGQHFIDTVLVHDTWGSMASGNFKNMSNQYAAMPSMHIGWSVWSGVIIFAMATAPWAKILGVLYPTLTLVVIVATANHFWLDAVGGVLCLLFGFAVSYAWYRALPHRLPQLVVELPRDPGTGGVRRFLPAART
>NZ_CP011340.1|WP_053557379.1|6148050_6151038_+|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase
MTVPGRRSSTFTRLLRHGFTDPSAAAQLLELPDMASVRSDPVLLDALGATADPDLALRSLVRLAEAHEPDERRRFLDNLITAKPLRDRLLGVLGASEALGDHLARHPRDWHALATYESADLHPGVADFERGLADATDPVSLRVSYRRCLLAIAARDVCGTTDVAEAAAELADLATATLRAALGIARTAAPHDAAACRLAVIAMGKCGGHELNYVSDVDVIFVAEPTGGTEEAKALQAATRLASHLMRICSETTVEGTIWPVDANLRPEGRNGPLVRTLSSHVAYYQRWAKTWEFQALLKARPVAGDLALGEAYTEAVAPLVWQAAERENFVADVQKMRRRVVDNIPVAEIERELKLGPGGLRDVEFAVQLLQLVHGRSDATLHSGTTLEALQALAAGGYVGRADAAQLDEAYRFLRAMEHRIQLHKLRRTHLVPEQEADLRRLARSLGLRTDPVTTLNREWKRHASVVRRLHEKIFYRPLLDAVAQLTPGETRLSPKAAGQRLEALGYADPAAAMRHLEALASGVSRKAAIQRTLLPVLLGWFADSADPDAGLLGFRKVSDALGKTPWYLRLLRDEGAAAENLARVLSAGRLAPDLLLRAPEAVAILGDPEGLRPRGRDHLEQEILAAVGRADTAEAAVAAARGVRRRELFRTAAADIIGSYGTEENPAEADAGALVDQVGDAITELTAATVAGALRAAVRDKWGDTLPTRFAVIGMGRFGGHELGYGSDADVLFVHQPRDGVDEQEAARAANAVVSEMRRLLQLPTADPPLLIDADLRPEGKSGPLVRTLASYGAYYRRWSLVWESQALLRARPMAGDTELAEAFIELVEPLRHPREGLDDEAVREIRRLKARMESERLPRGADPTLHTKLGRGGLSDVEWTVQLLQMRHGWEVPGLRTTRTREALRAARAAGLVSEDDARTLDEAWVLATRVRNGVMLVRGRAGDTFPSDVRELAAVGRYLGYGPGHVGDMLDDYRRVTRRARAVMEAAFYDA
>NZ_CP011340.1|WP_053557378.1|6147277_6147709_-|glyoxalase
MEMTLEVVPVPVADLDRAKTFYSEACGFKADIDSEVAPGMRIIQLTPPGSRCSIVLMSGMPAHPDQPTMSPGALHGLQLCVTDLAKAHSELMSRGVPVTSIQHVGPTGWEEGPGEEWNAFMFFKDPDGNSWCVQEAPAPLSER
>NZ_CP011340.1|WP_005318462.1|6163628_6164291_-|response-regulator-transcription-factor
MRVVLAEDLFLLRDGLVRMLEAFGFEILAAVETGPELGKALAELEPDVAVVDVRLPPSHTDEGLQCALAARRARPGLPVLVLSQHVEQLYARELLADGNGGVGYLLKDRVFDAEQFVDAVRRVAAGGTAMDPQVISQLLSRRSQDRPMGRLTPREREVMELVAQGRSNAAIASQLVVTERAVAKHTSNIFAKLGLPVSDDDNRRVLAVLAYLDHGRTNGS
>NZ_CP011340.1|WP_005318464.1|6164275_6165544_-|sensor-histidine-kinase
MAIKKARGALAAGGQGLVLASAALVGSVVLFSLATVSIALIPVGVGMFTTPRVLTLLRAHVNRRRLLAAQWSRVRIPVRYRPLPEDVRKGVTGQVERCSLMLRDPATWRDMRWLLADMTGGAVVAVLAPALILEGVFGLLLAAGLWKPIVEASGTYWYTFLPVDSSDTARLAALLGLVWMIVALHVNTRLVRAHFRLAGAVLNPGRQEELEQRIDRLTETRHDALDTSAAELRRIERDLHDGAQARLVAMGMNLGTIEALIEKDPAQAKELLSKARESSAEALTELRDLVRGIHPPVLAERGLGDAVRALALRLPVPAEVEVELPGRPDAPVESAAYFAVSEALTNAVKHSGADRVWVDMTYTDGALRISVTDNGKGGAVVGAGSGLSGVERRLGTFDGVLAVSSPAGGPTMVTMEIPCELF
>NZ_CP011340.1|WP_053557790.1|6166269_6167253_-|NAD-dependent-epimerase/dehydratase-family-protein
MRLLILGGTEFAGRAVTEAALARGWDVTVFHRGRHPAPKGAAVLLGDRLGDLDALAGGEWDAVVDTWSGAPSAVRRTARLLAGRVGRYVYISSCSVYVWPQPAGYDETAPLVDSSPDAVDVPYAEAKRGGELAVLDAFGEEHSLLVRSGLILGPWENIGRLPWWLGRIARGGDVLAPGPRENALQYIDVRDLAEWTLDAVAAGRSGPYNLVSEPGHTTMGELLDACVTVTGSTARLRWTEAETILAAGVEPWTDLPVWIPPTQEAYGALHAVNVDRATATGLRCRPVVDTVRDTWAWLQSLGGTAPHRVDRPRVGLSPEVEQRLLEG
>NZ_CP011340.1|WP_050791754.1|6167445_6167955_+|hypothetical-protein
MGHSSLSAHDIPPSALLAALVVTAAAGWFAAGRRRGPGAIGAGLLAVQGALHLIFSDAGQPAGHHPGHRAEAATGLADGAGMLAVHLLAAAGCALWLAHGEAAFFRLAGAAFAFAFTPLRLLLGAVRLPEPPRPVVRPVVRARHRSVVLAHTVVRRGPPPPAIPRATAP
>NZ_CP011340.1|WP_005318467.1|6168013_6169444_+|PepSY-domain-containing-protein
MSVDAPDQGAAPEAVTGRAESTSTWAALRPLVLRLHFYAGLLIAPLLLVAAVSGLLYSLSFQAEKFVYRDELTAPVSGPYLPLGAQVDAAREARPDATVTAVWPAYEEGMTTRVLMDAPGVAEGRSLAVFVDPYTTGIRGELPSYGSSGALPLRAWLDELHRDLHLGDVGRYYSELAASWLWVVALGGLLLWLGRRRRTKRDLVLPERGAKGRRRTLSWHGSVGLWAVTGLVLLSATGLTWSRYAGENIGALQDRLGGATPTVSAAIGEGGAAGGDGHEGHGGTGHGTQHQGADIGIDVAVAAAHEAGVDGRIAVTLPSDGTGYVVKETDTQYPVHLDSVAVDPADGRVIDELRFADYPLLAKLTRFGIDGHMGVLFGLANQLVLAALMGALILLIVWGYRMWWLRRPTKERTLGAGRPAPRGAWRKVPVTVLLPLAAATAAAGWFVPMLGISLLVFLAVDVAVGAAARTRARTGS
>NZ_CP011340.1|WP_005318469.1|6169440_6169977_-|winged-helix-turn-helix-transcriptional-regulator
MANTRSFSTVARPVRLPSDRHRLRAVDRDEVVDVADLLPPGATWLPAPPHTLPDLPGRPPMVGYLVLVPAGGQPLPTDAPREATDGGPVLIDPVRRTAQVDGRALDLTYLEFELLAHLVAHPQRVHTRDQLVTTVWGYGHVGDGRTVDVHVARLRRKLGAEHRRTIQTVRRVGYKYAP
>NZ_CP011340.1|WP_053557382.1|6170357_6171377_-|glutamine-synthetase
MTFKAEYIWIDGTEPTAKLRSKTKILNDGAELPVWGFDGSSTNQAKGHASDRVLKPVFSCPDPIRGGDDVLVLCEVLNTDMTPHESNTRAALAEVYERFAAQEPIFGIEQEYTFFDGERPLGFPAGGFPAPQGGYYCGVGADEIFGRDVVEAHLENCLKAGLGISGINAEVMPGQWEFQVGPLAPLEVADQLWVARWLLYRTAEDFKVSATLDPKPVKGDWNGAGAHTNFSTKAMREGYDAIITACESLGEGSKPLDHVKNYGAGIDDRLTGLHETAPWNEYSYGVSDRGASVRIPWQVEQDGKGYIEDRRPNANVDPYVVTRLLVDTCCAALEKAGQV
>NZ_CP011340.1|WP_037774862.1|6171862_6172783_+|Gfo/Idh/MocA-family-oxidoreductase
MTKQTQPLRIGLIGAGPWAGMTQAPALAGHPDVMFSGVWGRRPEAAAALADAHGTAAFTGDEGIEALFAVSDAVAFAVPPDVQAPLAARAAAAGRHLLLDKPVATNVAAARAAARAAQDAQVASVVFCTLRFAADTAPWVAEQAAADGWFTAHAQWLGSLYSDDSDSPFAASPWRREKGGLWDVGPHALSALLPVLGDVTTLSAGRGPADTVHLVLRHTSGASSTVTLGLSAPGKAAGTSLVLLGERGRAELPEGWGDPVDSFRRAVDALLGAARTGQAHDCDIHFGVRLTEILAEAEELLAGTAP
>NZ_CP011340.1|WP_037774864.1|6172977_6173673_-|hypothetical-protein
MSRKKTLSGKKKLALLVGAAAMAGGTAIVMTGTSQASVACDGLAQAVRNNENFIAGQRANPDAQSEARIANREAVIAQIRVQQEAAGCDAGDGGGQAAAPPAEQPPAEAPPAEEGAGEDQGSGEDQGAGEGQDAGQGDQAGEEAGGGATGEVVCAGSTVTLSGEGGAPAASSSEFPVGTQLKVTNLDNDKSTTVEVTSVSGSCALLNNAAFEQVREAGKFLIRNARIERVG
>NZ_CP011340.1|WP_037774869.1|6174308_6174671_-|arsenate-reductase-family-protein
MEIWINPACSKCRSAVDLLDAEGAEYTVRRYLEDVPTEDEIRAVLERLGLEPWDITRTGEAVAKELGIAGWPKDAASRDRWVAALSEHPKLIQRPIITADDGSAVVGRSEEAVRDALGRG

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Crispr_ID: NZ_CP011340_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_19

7135449-7135552

Orphan

Consensus_repeat	Method
ACACGCCGCGACCGCGGGCACCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_19

>merge|NZ_CP011340|19|7135449-7135552|CRISPRCasFinder
ACACGCCGCGACCGCGGGCACCTGAGACCGCCACCGGCCGCGGCCGGGGCCGCCCCGCCAGGTGGCCGGCGCCTGCGACGACACGCCGCGACCGCCGGCACCTG

>NZ_CP011340|19|18|7135449-7135552|CRISPRCasFinder
ACACGCCGCGACCGCGGGCACCTG	AGACCGCCACCGGCCGCGGCCGGGGCCGCCCCGCCAGGTGGCCGGCGCCTGCGACG
ACACGCCGCGACCGCCGGCACCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_005320082.1\|7122723_7124268_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_053557531.1\|7131203_7134017_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|377989
NZ_CP011340.1\|WP_053557814.1\|7139496_7139913_-\|benzoylsuccinyl-CoA-thiolase	unknown	unknown	gnl\|CDD\|224462
NZ_CP011340.1\|WP_005320111.1\|7146455_7147373_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_053557813.1\|7120142_7121015_+\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238870
NZ_CP011340.1\|WP_005320073.1\|7117702_7118827_+\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340842
NZ_CP011340.1\|WP_005320106.1\|7140373_7141189_-\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|350616
NZ_CP011340.1\|WP_005320110.1\|7144356_7146333_+\|acetoacetate--CoA-ligase	unknown	unknown	gnl\|CDD\|235134
NZ_CP011340.1\|WP_053557532.1\|7134013_7134469_+\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|367422
NZ_CP011340.1\|WP_053557528.1\|7124353_7125277_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_053557533.1\|7138312_7139500_-\|lipid-transfer-protein	unknown	unknown	gnl\|CDD\|180373
NZ_CP011340.1\|WP_037775282.1\|7121075_7122353_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340929
NZ_CP011340.1\|WP_053557534.1\|7139991_7140342_-\|DUF962-domain-containing-protein	unknown	unknown	gnl\|CDD\|377609
NZ_CP011340.1\|WP_053557815.1\|7141769_7144142_-\|glycoside-hydrolase-family-31-protein	unknown	unknown	gnl\|CDD\|376446
NZ_CP011340.1\|WP_106428475.1\|7141249_7141756_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240031
NZ_CP011340.1\|WP_005320101.1\|7137260_7138022_-\|aquaporin-family-protein	unknown	unknown	gnl\|CDD\|223653
NZ_CP011340.1\|WP_005320100.1\|7135664_7137179_-\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|198362
NZ_CP011340.1\|WP_005320076.1\|7118823_7119993_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340842
NZ_CP011340.1\|WP_005320095.1\|7134473_7134878_+\|DUF742-domain-containing-protein	unknown	unknown	gnl\|CDD\|283084
NZ_CP011340.1\|WP_053557530.1\|7130296_7130737_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_053557531.1\|7131203_7134017_+\|HAMP-domain-containing-protein	gnl\|CDD\|377989	pfam08376, NIT, Nitrate and nitrite sensing. The nitrate- and nitrite sensing domain (NIT) is found in receptor components of signal transducing pathways in bacteria which control gene expression, cellular motility and enzyme activity in response to nitrate and nitrite concentrations. The NIT domain is predicted to be all alpha-helical in structure.	2.0393e-35
NZ_CP011340.1\|WP_053557814.1\|7139496_7139913_-\|benzoylsuccinyl-CoA-thiolase	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	4.40887e-16
NZ_CP011340.1\|WP_053557813.1\|7120142_7121015_+\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238870	cd01832, SGNH_hydrolase_like_1, Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. Myxobacterial members of this subfamily have been reported to be involved in adventurous gliding motility.	3.95061e-44
NZ_CP011340.1\|WP_005320073.1\|7117702_7118827_+\|glycosyltransferase-family-1-protein	gnl\|CDD\|340842	cd03814, GT4-like, glycosyltransferase family 4 proteins. This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.	1.50356e-110
NZ_CP011340.1\|WP_005320106.1\|7140373_7141189_-\|M15-family-metallopeptidase	gnl\|CDD\|350616	cd14817, D-Ala-D-Ala_dipeptidase_VanX, D-Ala-D-Ala dipeptidase VanX. D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. It belongs in the MEROPS peptidase family M15, subfamily D.	2.72403e-134
NZ_CP011340.1\|WP_005320110.1\|7144356_7146333_+\|acetoacetate--CoA-ligase	gnl\|CDD\|235134	PRK03584, PRK03584, acetoacetate--CoA ligase.	0
NZ_CP011340.1\|WP_053557532.1\|7134013_7134469_+\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|367422	pfam03259, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	2.48057e-22
NZ_CP011340.1\|WP_053557534.1\|7139991_7140342_-\|DUF962-domain-containing-protein	gnl\|CDD\|377609	pfam06127, DUF962, Protein of unknown function (DUF962). This family consists of several eukaryotic and prokaryotic proteins of unknown function. The yeast protein YGL010W has been found to be non-essential for cell growth.	5.85029e-32
NZ_CP011340.1\|WP_053557533.1\|7138312_7139500_-\|lipid-transfer-protein	gnl\|CDD\|180373	PRK06059, PRK06059, lipid-transfer protein; Provisional.	0
NZ_CP011340.1\|WP_037775282.1\|7121075_7122353_-\|MFS-transporter	gnl\|CDD\|340929	cd17371, MFS_MucK, Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.44799e-141
NZ_CP011340.1\|WP_106428475.1\|7141249_7141756_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240031	cd04674, Nudix_Hydrolase_16, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.36412e-46
NZ_CP011340.1\|WP_005320101.1\|7137260_7138022_-\|aquaporin-family-protein	gnl\|CDD\|223653	COG0580, GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism].	2.32611e-63
NZ_CP011340.1\|WP_005320100.1\|7135664_7137179_-\|glycerol-kinase-GlpK	gnl\|CDD\|198362	cd07789, FGGY_CsGK_like, Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases. This subgroup corresponds to a small group of bacterial glycerol kinases (GK) with similarity to Cellulomonas sp. glycerol kinase (CsGK). CsGK might exist as a dimer. Its monomer is composed of two large domains separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The regulation of the catalytic activity of this group has not yet been examined. Members in this subgroup belong to the FGGY family of carbohydrate kinases.	0
NZ_CP011340.1\|WP_005320076.1\|7118823_7119993_+\|glycosyltransferase	gnl\|CDD\|340842	cd03814, GT4-like, glycosyltransferase family 4 proteins. This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.	4.3995e-64
NZ_CP011340.1\|WP_005320095.1\|7134473_7134878_+\|DUF742-domain-containing-protein	gnl\|CDD\|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	5.79895e-32
NZ_CP011340.1\|WP_053557815.1\|7141769_7144142_-\|glycoside-hydrolase-family-31-protein	gnl\|CDD\|376446	pfam01055, Glyco_hydro_31, Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.	2.01352e-122

>NZ_CP011340.1|WP_005320095.1|7134473_7134878_+|DUF742-domain-containing-protein
MSESLRHGRRSHHWIDADAGPVVRPYAMTRGRTSHAGRHRLDLIALVVPEAAADDPGRDQTLSPEHVEIVERCGSTPQSIAELAAGLDLPVGVVRVLVGDLVDDALVHVTRPVPPAELPDVSILREVINGLRAL
>NZ_CP011340.1|WP_053557532.1|7134013_7134469_+|roadblock/LC7-domain-containing-protein
MTAPHAAATDATGDRFGAQRPGGLNWLLDELVDRVASIRKALVLSSDGLATGTSRELTREDSEHLAAVASGFHSLAKGVGRHFDAGQVRQTVVELDEAFLFVTAAGDGSCLAVFADADSDVGQVAYEMTLMVKRVGAHLVTAPRTGQAAGG
>NZ_CP011340.1|WP_053557531.1|7131203_7134017_+|HAMP-domain-containing-protein
MRFRGKSIRRKIVALLLVPLLSLTALWGFATVLTGREANQLLAASSVAEKVGMPVEDTIDVIQQERRQTLVYLADRRASGAQQTMNTRRSATDTAVAAVRRNAQSSSVREDLTSDSSRRLTSLMEAFDGLDALRRSVDTNTVTRAQALEFYNGLIEPSHGFLLTLHALDDVELERQGRALVGLSRAREMLSREDALIASALTTRKTTAREIRELSDHAAHRQVYYETNLEMLPARDRGTFQQYWRSPETAPLRDAEERIIAAGPSEGLPPSEAERWQQAATPVLDNLDREAADARDRYQDRVEPAAYGVLVKAGVAGVLGFLALLVSVIVSVRIGRDLVRDLSRLRKEAHEVSGVRLPSVMRRLAAGEHVDVETEAPRLEYEKDEIGQAGQALNTLQRAAVEAAVRQADMRRGVSEVFVNLARRNQVLLHRQLSLLDTMERRTEDTEELADLFRLDHLTTRMRRHAEGLVILSGAAPSRQWRKPIQLMDVVRAAVAEVEDYERIEVRRLPRIGVGGPAVADLTHLIAELLENATVFSPPHTGVQVLGERVANGFTLEIHDRGLGMAADALLEANLRLAETPEFELSDTDRLGLFVVSRLAQRQNVRVSLQQSPYGGTTAVVFIPAALLTEAPETQGTGFRLDRKSESAAGRRGDGRQPALTKLPSGLGGAAVLDGPVELEAPIGALGPDERDRSLLGDDPTLPADPGRLADLEDSESERGGIFRPRRRGEATGEQHQQARERSEEHRAGPVPLPRRRPPTLVADHGRRVDERATDGRGHPTPDSGRAVEPTPFARPPLSAAPTPLTAERRERGRSGPVSGPAPVPPSGDGAPPWPARQSDGDTAPLLDGLPRRVRQASLAPQLRASGSAAGPGAASPEAGEPERDAEEVRSRMASMQRGWQRGRRRNAEEAAAEQGTDPAVGDGRTAPGSTSEGDGR
>NZ_CP011340.1|WP_053557530.1|7130296_7130737_-|hypothetical-protein
MDTDERREATPAVDDLCVPRQLWVEEPATRRRMAEPVRRAAVRAVIIVSLTMIQAMTALLFTLSGAWLAFPLVLSTVAGTVVATWAVLDVWVTRQVWNQRNGVVSVPSSTARQLRRERRRARRAARAAARGASRIRQRAGGRLSQA
>NZ_CP011340.1|WP_053557528.1|7124353_7125277_+|hypothetical-protein
MSDHHAEPPAAWSDPAAPQGPPSGPMSAAAPGPGGVTPADAADAARLVSFGLQPKLLPARDAEYAELLRRYREDPAFARLADAVATGLGLVVLEVSPRAGMAVTAGEDSVFAVRMGDYARRASAESADRFLHGLAHLAVAALAFPRPEDLADDGYIGRITVNGVDAFVRQACRRLEERADEQGENTDPASDAPGLEAAWRVYARRSATGATKDARRLAGSTTGIVGKAVAFLTDSGFLQRTGDDAGGAYRTTARYQLQVRDMAGSAAMAELLELGVVPVGDGSATLVAPPDGDDLDLAADAGLPFHA
>NZ_CP011340.1|WP_005320082.1|7122723_7124268_+|hypothetical-protein
MTSPASTDLAPPQLSAGPRPAQGPAADEGLARRLRALACTAPLHDLDVRKANLAGEYSVYAMAEVALAAIDLVTLNMDFDTGADHDQIVARLVPRVAAQAPRRPAAEHERVARWVLENLINVGSVDRGFRAVYGTFGPDGVYTRRDYDFKLIEEVPGRDGTVYLRTTDEAVNVLVGALDTDVTSAQIAAEVKLEVLISRGRLADAQLAAEQARYRTVQYSETLRRTLEATRRNVRAVDWLNTVPDMIAEALDHVADRYRHENAILTNIRKARDEAETGADPKTAEHKRRAAELVDIVKDCIRRHTQLQSRLLEAGPLFRAEQDRQAFARPAARSGLDLYGQLLAPLLPLPVESAIRVTDAFFASGTGLRTPSSVRVGDLVDLLLTPPAEREHLGAEMPEPDLIATPDDSRFSEEQLASAMELLDLEHDAPRRLSGLLAEARRRDPDLPYLVALLAVHAASPPVGTAYRQGEQRLLFAVDDGTELDDPEFGGADLIVGTALLDAVGMAAARSEAT
>NZ_CP011340.1|WP_037775282.1|7121075_7122353_-|MFS-transporter
MSTPQVRQKHDQLPEDSGTFAWLRALGPRGRRAFGGAFGGYALDSYDYFTLPLSMVAISAYFSLDNGRTGLLTTVTLVVSAVGGALAGILADRVGRVKALMATVITYAVFTVLCGFAPNYETLLVFRALQGLGFGGEWAVGAILVAEYATAKHRGRTLGAVQSAWAAGWALAVIVYTLVFRFVDADTAWRVLFWTGALPALLVIYVRRNVSDAPKAAEVRRAGTARGSFTTIFKKDLLRITLFATLLSTGVQGGYYTLATWVPTYLKTERGLTVVGTGGYLTFLISGAFIGYLTGGYLTDRIGRKKNIALFAVLSSVGIIAYTNIPPGSNSLLLVLGFPLGFCMSAIFSGFGSFLSELYPTAVRGTGQGFTYNSGRAVGAFLPTLVGFLSDSWGVGGALVLGAAGYGLAVLALTGLPETRDRELL
>NZ_CP011340.1|WP_053557813.1|7120142_7121015_+|SGNH/GDSL-hydrolase-family-protein
MRTVRFAALGDSLTAGVGDPVAGGRRGWAALLAGTMGGAGMSVVFRNLAVSGALSKDVAEIQAPAALAFSPDVASVVVGVNDTLRRTFDIADVARRLDGVTSALAARGTVLLTACLPDPGAMFGLPAPLARPLARRQRAVNAVVHALSDRYDTVHLHAAEAAWVADRAMWSADRLHPGERGHRMLARRFHELLAARGLADGLPPDAEPDQPPVTAAASLLWLATAGTAWTARRCTDLLPQLLRLAGDEVHHWVRGTSARLDRSSDLALSAALAAVSPAVPGARPGPGAGD
>NZ_CP011340.1|WP_005320076.1|7118823_7119993_+|glycosyltransferase
MSGEHGLRIVRLANFVTPSSGGLRTALAELGRGYLAAGHEPVLVVPGDVESDRHTDQGRVITLPGPEIPGTGGYRVLAGRRRLRRVLEELAPDRLEVSDRTTLRWTGEWARRRRIPSVMVSHETADGVLRTWGLTGSVAAGTADRLNRRSAWAYSRIVCTTEWAEREFVRIGARNVVRAPLGVDLRRCRPERRSALLRARHAAGADVLLLLCSRLSVEKRPATALDALAALRERGLRVSMVVAGDGPLKASLVRRAHTDRLPVRFLGHVPDRESVADLQAAADVCLAPGPAETFGLSALEALACGTPVVASASSALPEVVGDAGIAAADTGADFAAAVLELLSRPAEARRRVARARAELFGWQRSVAAFLAAHQALPAGDPASGPGSGR
>NZ_CP011340.1|WP_005320073.1|7117702_7118827_+|glycosyltransferase-family-1-protein
MRVVIVTESFPPDVNGVAHCAQQTARHIAARGHEPLVVAPAAAGATSCDAAAPYPVVRVPSLPLPGYPQVRVALPSRRVAAAIAAHRADLVHLASPFVLGVRGMAAAARLGLPAVAVYQTDLAGYARTYVGAGEGAAWRRIRAVHGAADRTLAPSTAALRDLEEHGVERVRLWPRGVETTRFRPELRDEELRRTLAPDGEVIVGYVGRLAPEKHVELLAGVCALPGVRLVVVGDGPSGAALRAALPGATFLGRRTGDDLARIFASLDVFAHTGPYETFCQTVQEAMACGIPVIAPAAGGPLDLVAHGRTGLLVEPHSADAVRAAVVALAGDPALRAAYGRAGLAAVEGRTWAVVGDLLLDHYADVLGARTAVAA
>NZ_CP011340.1|WP_005320100.1|7135664_7137179_-|glycerol-kinase-GlpK
MTDRFVAAIDQGTTSSRCIIFNQDGAIVAVDQREHRQIFPKPGWVEHDATEIWSKVQAVVAGAVAKAGLRADQLSALGITNQRETTLMWERATGKPVHNAIVWQDTRTAALCHELGGADGQDRFRDATGLPLASYFSGPKAAWLLDNVPGLRARAERGEIAFGTVDSWLIWNLTGGTDGGVHVTDVTNASRTMLMDLRTLQWDEEILAAMNVPKAVLPEIRSSSEVYGTAVGQLAGVPVASALGDQQAAIFGQACYDTGTAKNTYGTGSFLLLNTGNRPVPSKSGLITTLGYKIGDESPVYCLEGSIAITGALVQWFRDQLGIIRSAGEIETLAASVEDNGGAYIVPAFSGLYAPYWRSDARGVVTGLTRYVTKAHLARAVLEATSWQTREVVDAMYQDSGVQITTLKVDGGMTANHLLMQHQADVLGVPVIRPKVSETTCLGAAYAAGLATGVWADLDELKTHWQRDVEWSPRMEAEVREREYHNWRKAVEKSFGWEEEAGGS
>NZ_CP011340.1|WP_005320101.1|7137260_7138022_-|aquaporin-family-protein
MSNSDIFLGEVIGTAILILFGAGVCAAVTLYHSKARAAGWVVIAFGWGFGVLAGAYTAAPLSGGHLNPAVTVGLAVDTGEWSKVPLYILAQMVGAVLGAVLAYLVYFAQFQANADTAHAQPTLGIFATGPEIRKPWANVLTEVIATIGLVLPLLAFGRNDGIGIGQIPGQDAGIYGSGISILLVSLLVVGIGLSLGGPTGYAINPARDLGPRILHAVLPIPNKGTSDWGYAWVPVAGPVIGGLLAGLIFNAAF
>NZ_CP011340.1|WP_053557533.1|7138312_7139500_-|lipid-transfer-protein
MSGDVAVLGAGMHPWGKWGRGFVRYGTAAARAALADAGVEWRQVRSVVGANTVRGGYPGQVSGAAFAQALGWQGARVTSVYAACAAGAQAIATARAQILAGLADVVLVVGAESAPKGFFAPAGGDRPEDPDWLRFRMLGATNPAYFGLYARRRMALHGDTTEDFALVKVKNSAYGALNPYARYRERVSAEQVAASAPVADPLRLLDICATSDGAAALVLSGMDFARRHGATDPVRIRAVSTVTPGYPRQGLDLPDIATDSAAALPPARPFRASIALAAYEEAGLGPEDLSLAEVYDLSTALELQWYEDIGLCPEGEGAALLRSGATGPGGRVPVNPSGGLASFGEAVPAQAIAQVCELTWQLRGTAGDRQVPGARAGITANQGLFGHGSAVVAVR
>NZ_CP011340.1|WP_053557814.1|7139496_7139913_-|benzoylsuccinyl-CoA-thiolase
MVTGWFTDGGEEGFRLLGTRCRDCSSVFFPREDAFCRNPACAGDVLEEVALSERGRVWSYTDGRYRPPAPYVCDPDVPWEPYALVAVELEAERMVVLGQAAPGVRTTDLAVGMEVEVVPGVLADGSPTWHWRPVGTTA
>NZ_CP011340.1|WP_053557534.1|7139991_7140342_-|DUF962-domain-containing-protein
MAQQQTFESYEEFWPYYVAMHSRAATRWVHLTGTLTGLAVSVYGLARGRKRYAAALPLIGYGTAWPAHFLIEGNNPATFGHPAWSLRGDVQMIRMMLSGRDGELAEIAAKWLAENR
>NZ_CP011340.1|WP_005320106.1|7140373_7141189_-|M15-family-metallopeptidase
MTRLGSAVRVLTAAAAALLCVTTAAPAAGAAPEPKAPREFVALRTVAPTIIQEMRYTTEHNFVGEPVDGYRQPVCILTRPAAEALRRAQSQLLRQGYSLKVYDCYRPQRAVDHFVRWAKDLQDEEMKQEFYPKVDKSRLFADGYIAEKSGHSRGSTVDLTIVKLPAAPTRPYVPGEALVPCYAPQEDRFPDNSVDMGTGYDCFDTLSHTDDPRVGPEQRANRDLLRGTLAAVGFVNLPEEWWHFTYKPEPFPGTYFDFPVAVRSVAGHRAG
>NZ_CP011340.1|WP_106428475.1|7141249_7141756_+|NUDIX-domain-containing-protein
MSKDSHCGNCGAPYGADAGRPRTCPACGTTAYSNPLPVAVALQPVRDPAHGTGLVVITRSIEPARGGTALPGGFIDHGEDWRHAVVRELREETGLEVPEHEVRLADVLSSPAHLLVFGLLPERPAAALPPFVPTAETGGRRLLHAVETLAFPLHTVAVRNWFAGAYDR
>NZ_CP011340.1|WP_053557815.1|7141769_7144142_-|glycoside-hydrolase-family-31-protein
MDGRDLVRAVTTLGTAQGLRVMRSAWRRHRADATGLPPRGAERARVPGPAEGAEPLPGGGTVRFARSELHIIVTVGGAVFRGWDGARPEPSYALAGPPPEPDPRAGLEPDKDGGWQVVSERLTVVVSRHGAVEIRTPGGVVLRRDLPPRWWEPVEGGPARWVQRSEIAADARLFGLGGRASGPRLRDGTYRLWNTAPRAGFGPGDDPLHVTMPVQTVVADAGCHLAFHDNTWDGRVIVREGREGAGSGHDRPGTVEVRMDGGPLRSWVLVGPPARVLGGWAQLTGAPALPPSWALGPQHVRPGGEEDVRRAVDAHREHGLPLSAVHVGGGGPRRAPAGPAADLEGFPRLSALAKDLRDDGVRLVRAVGPAVGAGPMEALYGHGSAAGLFVRDAGGAEVRGVSGRGDCVFPDFTDPRVREWWGELSGQGASEGFAGMWLDGNEPVSCTVFAGATLPRSSRHVLEGRGGDHREAHNVYGLAMARAAYEGMRGVFPEERPFVVSRSGWAGMQRYGGAWAGDVTAGWPGLRASLSLVLGLGLCGVPYSGPDVDGDDGPSAELFLRRLQLSSYMPLLRMRASASPWVYGPEVMAQARAVLVERRRLGPYFMTLAHLARLAGAPYVRPLWWRSPGDRALRDCEDAFLLGDSLLVAPVLEPGADRRAVRLPRGRWYDTHSGRPYDGPGQVLVDAPLSRIPVLARAGAVLPVLDDGGAQGDASQAAGTRTGRVGLEVWAPAAGRRGGGLVVRDAGEGWAEPEIERYTSRLAGGRVVVERATDDGQSAVEGPVRVRGLE
>NZ_CP011340.1|WP_005320110.1|7144356_7146333_+|acetoacetate--CoA-ligase
MTSAANHAPLWQPDPDRIAAARITRFQAWAAEHHGAPAEGGYQALHRWSVEELETFWQAVAEWFEIRFSTPYAQVLGDRSMPGAQWFPGATLNYAEHALRTAQDPARAHDPALLHVDETHEPTPISWSELRRQVGALAAELRALGVRPGDRVSGYLPNIPQAVTAFLATAAVGAVWTSCAPDFGARSVLDRFQQVEPVVLFTVDGYRYGGKEHDRTGTVAELRRELPTLRAVVHIPLLGTEAPEGTLDWSAVTAGDTEPVFEQVPFDHPLWVLYSSGTTGLPKAIVQSQGGILLEHFKQIGLHCDLGPGDRFFWYTSTGWMMWNFLVSGLLTGTTVVLYDGSPGYPDTGAQWRVAERTGATLFGTSAAYVMACAKADVHPGRDFDLSRVKCVATTGSPLPPDGFRWLHDEVADDLWIASVSGGTDVCSCFAGAVPTLPVEIGELQAACLGTDLRSWDPEGKPVVGEVGELVVTNPMPSMPIRFWNDPDGSRYRDSYFEMYPGVWRHGDWITITDRGSVIIHGRSDSTLNRQGVRMGSADIYEVVERLPEIRESLVIGLEEPDGGYWMPLFVHLAEGAALDDGLRARIKQSIRENLSPRHVPDDIIEVPGVPHTLTGKRIEVPVKRLLQGTPLAKAVNPGSVDNLELLAFYEAIARNRT
>NZ_CP011340.1|WP_005320111.1|7146455_7147373_+|hypothetical-protein
MAHTKQSKRAGTDAAQRRALRREVPSTVGILADEQDFTRMRRYRTFAFDDYTTYLRQSEQLLKTLSARQLHTSVALFDPEEFAEYCAEAGIDADAPAGRSRFTAELAGRGANVPYTGQPLGNLLPQLINRTVRRATWEYATLLLADLGMCADCGQDIGRSAFDRASNILMRLLEVAGPGEHHLVCSVPGPDEQLLAVLHAQGGTTPSASSAQIDAEEGAEFVTVLAAGIALEGTGGLVLRTSGPDTADRVHGWRLHRGRLEPLTAGEVFSAYCTDAATGDPLSPEPGVEYCAGFPVTTDDPDSHH

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Crispr_ID: NZ_CP011340_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_20

7402603-7402932

Orphan

Consensus_repeat	Method
TGTCGCCGACCAGGCTGTCGTCGCCCG	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP011340_20

>merge|NZ_CP011340|20|7402603-7402932|CRISPRCasFinder
AGTCGCCGATGAGGCCGTCGTTGCCCTCGCCGCCTTCGAGGCGGTCGCTCGCGCCGCCGGAGGCGCTCTCCCCGTTGGTGTCGCCGACCAGGCTGTCGTCGCCCGGGCCGCCGTACAGGGAGTCGCGCGCTGCCCCACTGGCAGTGCCCTGGAAACCCGCGGAGTTGTCGCCCACCAGGCTGTCGTCGCCCGCGCCGCCGAGCAGACGGTCCGTTCCGGTGGCGCCCGTAACGCCGGTCGCGTCGAAGCTGTCCCCGACAACTCCGTCGTTGCCGTCACCGCCGTCGATCGAGTCATTGCCGGGGCCGCCCCTCAGGCGGTCGTCGCCAC

>NZ_CP011340|20|19|7402603-7402932|CRISPRCasFinder
AGTCGCCGATGAGGCCGTCGTTGCCCT	CGCCGCCTTCGAGGCGGTCGCTCGCGCCGCCGGAGGCGCTCTCCCCGTTGG
TGTCGCCGACCAGGCTGTCGTCGCCCG	GGCCGCCGTACAGGGAGTCGCGCGCTGCCCCACTGGCAGTGCCCTGGAAACCCGCGGAGT
TGTCGCCCACCAGGCTGTCGTCGCCCG	CGCCGCCGAGCAGACGGTCCGTTCCGGTGGCGCCCGTAACGCCGGTCGCGTCGAAGC
TGTCCCCGACAACTCCGTCGTTGCCGT	CACCGCCGTCGATCGAGTCATTGCCGG
GGCCGCCCCTCAGGCGGTCGTCGCCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_005320559.1\|7412585_7412765_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_037775362.1\|7410857_7411676_+\|DUF4397-domain-containing-protein	unknown	unknown	gnl\|CDD\|379570
NZ_CP011340.1\|WP_078535538.1\|7403706_7404147_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP011340.1\|WP_037775359.1\|7391712_7393002_+\|aldolase	unknown	unknown	gnl\|CDD\|367449
NZ_CP011340.1\|WP_005320560.1\|7412924_7413968_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239217
NZ_CP011340.1\|WP_005320526.1\|7390580_7391543_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NZ_CP011340.1\|WP_053557566.1\|7396144_7397107_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP011340.1\|WP_050791613.1\|7394938_7395919_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP011340.1\|WP_005320538.1\|7397318_7398197_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236600
NZ_CP011340.1\|WP_005320554.1\|7409023_7410004_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133379
NZ_CP011340.1\|WP_005320558.1\|7411876_7412311_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005320542.1\|7400687_7401608_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP011340.1\|WP_005320549.1\|7404275_7406393_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP011340.1\|WP_005320552.1\|7407583_7408957_+\|deoxyribodipyrimidine-photo-lyase	unknown	unknown	gnl\|CDD\|223492
NZ_CP011340.1\|WP_053557567.1\|7406471_7407374_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235633
NZ_CP011340.1\|WP_053557565.1\|7393078_7394908_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP011340.1\|WP_005320541.1\|7399740_7400691_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP011340.1\|WP_005320556.1\|7410141_7410756_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|237125
NZ_CP011340.1\|WP_005320540.1\|7398403_7399741_+\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NZ_CP011340.1\|WP_005320524.1\|7389737_7390523_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|238847

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_037775362.1\|7410857_7411676_+\|DUF4397-domain-containing-protein	gnl\|CDD\|379570	pfam14344, DUF4397, Domain of unknown function (DUF4397). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 120 amino acids in length.	1.95506e-26
NZ_CP011340.1\|WP_078535538.1\|7403706_7404147_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.17715e-11
NZ_CP011340.1\|WP_037775359.1\|7391712_7393002_+\|aldolase	gnl\|CDD\|367449	pfam03328, HpcH_HpaI, HpcH/HpaI aldolase/citrate lyase family. This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.	1.83572e-06
NZ_CP011340.1\|WP_005320560.1\|7412924_7413968_+\|NUDIX-domain-containing-protein	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	8.28446e-15
NZ_CP011340.1\|WP_005320526.1\|7390580_7391543_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	2.62969e-107
NZ_CP011340.1\|WP_053557566.1\|7396144_7397107_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	6.52985e-66
NZ_CP011340.1\|WP_050791613.1\|7394938_7395919_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.38493e-95
NZ_CP011340.1\|WP_005320538.1\|7397318_7398197_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236600	PRK09636, PRK09636, RNA polymerase sigma factor SigJ; Provisional.	1.11144e-79
NZ_CP011340.1\|WP_005320554.1\|7409023_7410004_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133379	cd01104, HTH_MlrA-CarA, Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA. Helix-turn-helix (HTH) transcription regulator MlrA (merR-like regulator A), N-terminal domain. The MlrA protein, also known as YehV, has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella typhimurium. Its close homolog, CarA from Myxococcus xanthus, is involved in activation of the carotenoid biosynthesis genes by light. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules. Many MlrA- and CarA-like proteins in this group appear to lack the long dimerization helix seen in the N-terminal domains of typical MerR-like proteins.	1.10059e-18
NZ_CP011340.1\|WP_005320542.1\|7400687_7401608_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.20306e-77
NZ_CP011340.1\|WP_005320549.1\|7404275_7406393_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	7.55476e-76
NZ_CP011340.1\|WP_005320552.1\|7407583_7408957_+\|deoxyribodipyrimidine-photo-lyase	gnl\|CDD\|223492	COG0415, PhrB, Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair].	1.50389e-128
NZ_CP011340.1\|WP_053557567.1\|7406471_7407374_+\|SDR-family-oxidoreductase	gnl\|CDD\|235633	PRK05872, PRK05872, short chain dehydrogenase; Provisional.	9.25368e-111
NZ_CP011340.1\|WP_053557565.1\|7393078_7394908_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.46493e-107
NZ_CP011340.1\|WP_005320541.1\|7399740_7400691_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.49076e-67
NZ_CP011340.1\|WP_005320556.1\|7410141_7410756_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|237125	PRK12519, PRK12519, RNA polymerase sigma factor; Provisional.	1.25533e-32
NZ_CP011340.1\|WP_005320540.1\|7398403_7399741_+\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	1.18041e-28
NZ_CP011340.1\|WP_005320524.1\|7389737_7390523_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	9.40146e-81

>NZ_CP011340.1|WP_005320542.1|7400687_7401608_+|carbohydrate-ABC-transporter-permease
MTLDTAPPPTRTTAVAPVRSRPRRGPGRFGVHAFLMAVSLAFLAPLILAVYASLRPYEETSEHGYFSWPDNLSLDYYQQAFTDSGMTKYFVNTLIIAVPGVLLALFFASFVAFAVARLRLRGSIVLLMLFTAGNLLPQQVIVTPLYVLFNRIPLPYWMSDSMTMFDSYWAVVLVQTGFQIGFCVFVLANFMRTLPQEILEAAIVDGAGVWTQYWRVTLPLCRPALAALGTLQFTWMYNDFLWALVFISDGDKLPITSALNNLRGQFFTDYNLLAAGSVIVALPTLVVFLLLQRHFIAGLTLGSTKG
>NZ_CP011340.1|WP_005320541.1|7399740_7400691_+|sugar-ABC-transporter-permease
MPIGRLMPMMREREAPPVPTRTVGRRRRFTRRDAGVIGVLLGIPVLLDVFVVWGPTLASVVLSFTSWDGIGDISWVGTDNYENLFTNYPAFWPAVRHNVLWLAFLGLVSTPFGLLLAVLVDRGVRFSRFYQSALYMPVVLSLAVVGFIAQLVFSRDQGALNAVLGGGTNPTDWLGDPDLNIWMILLAAAWRHTGYVMILYLAGLKAVDPALKEAAAIDGASERQTFFRVVLPTLRPVNIIVGVITVIEALRAFDIVYAVNKGRNGLELLSVLVTDNIIGEASRIGFGSAIAVVLLLVSMGFVVTFLVQEMRGEKNR
>NZ_CP011340.1|WP_005320540.1|7398403_7399741_+|carbohydrate-ABC-transporter-substrate-binding-protein
MAQVSFDGSAVPGGRVSRRSLLRGAAAGAGAVALPAVLAACGSGPGGDGRTIRLGSNSSDPVPKKAFAAAFAAYEKQSKEGRKVKVNTVDHNTFQENINRYLQGKPDDVFMWFAGYRMQFFAKKGLLHDISDIWGSYEGFSPALKAQSTGEDGKQYLTPYYYYPWAVFHRRSVFEERGYQAPGTLDEYIALARQMQKDKLVPIAFCDKDGWPAMGTFDYINMRTNGYEFHRRLMAGEEAWTSNEVRQVFDTWRSLLPYCQPAANGRTWQEAATSLQKKQAGMAVFGLPHPGQQFPEEEQDDIDFFPFPVINPEHGQDAVEAPIDGFLLAKKSKSLKQDKVMESAKDLLKWLSTGEAEDIYLAGDPNNIAVSDRADTSKYTALQKKAVELVSGAKQISQFLDRDTRPDFSSVVMIPAIQSFINDPKDVDGLVNGIERQKKTIFAAD
>NZ_CP011340.1|WP_005320538.1|7397318_7398197_-|sigma-70-family-RNA-polymerase-sigma-factor
MDEHAWSKERFEEHRPRLKAVAYRMLGSASEAEDAVQEAWLRVDRAGTSDIENPGGWLTTIVARVCLNMLRTRERRREEPLEPATADKADGPDPEQEALLADSVGLALLVVLDMLSPAERLAFVLHDMFAVPFDEIAPMIERSPTATRQLASRARRRVRGTAPAPETDRTQQRRVVEAFLAAARGGDFDALVAVLHPDVVFRADRAVGPTPEPLVFHGAEAVARGASAASERVRFSEPALVNGSVGLVMAPRGRLFLVLEFTIEDDRITEIDVIAEPDRLREVHLALLDSPA
>NZ_CP011340.1|WP_053557566.1|7396144_7397107_+|ROK-family-protein
MHNSLVAALDIGGTKIAGALVDGNGAILHRAQCPTPAHDDGETVMRAVESILAELTASPLWVRATALGIGSAGPVDASAGTVSPVNVPGWRAFPLVDRVSHAVGRHLPVTLVGDGVAMTAAEHWQGAARGYDNALCMVVSTGVGGGLVLGGKPHAGPSGNAGHIGHISVDLDGDLCPCGGRGCVERIASGPNIARRALENGWRPGPGGDTSAAAVAEAARAGDPVATASYERAAQALAAGIAATATLVEIEIAVVGGGVAGAGEVLFGPLRRALRDYAALSFVQRLTVAPAVTGTDAGLVGAAAAATLGQGEAAVPAGRA
>NZ_CP011340.1|WP_050791613.1|7394938_7395919_-|LacI-family-transcriptional-regulator
MKDVAARAGVGLKTVSRVVNGEPGVTPDTERRVQEAIESLGFRRNDSARVLRKGRTASIGLVLEDLADPFYGPLSRAVEEVARAHGALLINGSSAEDPEREQELALALCARRVDGLIVIPAGDDHRYLEPEMKAGVATVFVDRPPGRIEADVVLSDSFGGARAGVAHLIAHGHRRIAFIGDQPRIHTAVERLRGYRAAMEDAGLVIDDSWVALGSTAPERVQEAVKSVLAGPEPVTAIFAGNNRVTVTAVRVLAGHDQRVALVGFDDIELADLLGITVIAQDAAALGRTAAERLFRRLDGVNDEPSQVALETVLVPRGSGEIPPPS
>NZ_CP011340.1|WP_053557565.1|7393078_7394908_+|serine/threonine-protein-kinase
MSTGENERLAGRYRLVGQLGRGGMGVVWRAVDEVLGREVAVKELRTYTDSSAPELADLTVRMQREARAAARVRHPGVVAVHDVAEHEGRPVIVMELVDGPSLDDVLNTRGVLDPREAAGIGARVLEALGAAHRAGVLHRDVKPGNVLLDRSGRVVLTDFGIAAMDDPGDGSTSRLTRSGEIVGSLDYLAPERAQGNDPGPASDVWALGATLYAAVEGSSPFRRTSTWSTLTAIVAEPLPEPLRAGPLAPVLRQLMHKDPARRPDADAAARMLSAVAAGEDPAGHTAPLGPPVDGPREQAPPRVPTVLSAAPYQPQGFGPAEPEPAAGGAVPGPPGTYAAPAAGAVPGPVASYTPQAAGPPGTPPGGGPVRHGRGKVMIAAAVAAVLLAGGGVTYALVGKDDGGTTRGDLAGGEAAGPSAGAGPSGDTPGTGPAGERSPSAGSGPDEKGGEGTKSPSPASKAPVPGGAAAEPDAGDSTGGSESGSGGGSDGGASGGSTGGSSTGGGGTTGGGDSEPAPACHAIGAGKYNCQVWKTAQSYNDGGAQVGVLNAGTNYFYCQANLGRRETSGEWTNVWWAKTDDDSGNRNVWVSDVYVQGGANDEPVPGLPVC
>NZ_CP011340.1|WP_037775359.1|7391712_7393002_+|aldolase
MGQQEKVATSLAGAVSEDISASLATVDAELARRYPGDPGTRQPVHTVYVPGNDFAADTIRSWGDRALAALDEHAPDARTFARVLGLADELAEPVYTRVRAKLEREPVEDLRVDFEDGYAGPDEDADAARAARLISEAYEQGTAAPYMGIRMKCMEAAVRDRGIRTLDIFLTGLMERGGLPGGLVLTLPKVTYPQQVTAMVRLLEQFEKSRGLEPGRIGFEIQIETSQSILAADGTATVARMIDAAEGRATGLHYGTFDYSACLGVSAAYQSSDHPAADHAKAVMQVAAAGTGVRVCDGSTNVLPVGPAEKVHDAWRLHHGLTRRALARAYYQGWDMHPGQLPTRYAAVFAFYREGFEQAAARLAAYAGHVGGDVMDEPATAKALSSYLLRGIDCGALDEAEVTGLTGLDRASLDGFARPRRGDLTATAG
>NZ_CP011340.1|WP_005320526.1|7390580_7391543_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MAEVLVYVDHVDGAVRKPTLELLTLARRIGEPVAVALGSGAESTAAALAEHGAVKVLTADAPEFAEYLVVPKVDALQAAYEAVSPAAVLVPSSAEGKEIAARLAVRIGSGIITDAVDLEAGDEGPVATQSAFAASFTTKSRITKGTPVITVKPNSAAVEAAPAAGSVEALSVSFSEQATGTKVTSRTPRESTGRPELTEAAIVVSGGRGVNGAENFAIIEALADSLGAAVGASRAAVDAGWYPHTNQVGQTGKSVSPQLYIASGISGAIQHRAGMQTSKTIVAINKDAEAPIFDLVDYGVVGDLFEVVPQLTEEVKTRKG
>NZ_CP011340.1|WP_005320524.1|7389737_7390523_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MSLRIVVCVKYVPDATGDRHFADDLTVDRDDVDGLLSELDEYAVEQALQIADEADDAEVTVLTVGPEDAKDALRKALSMGADKAVHVEDDDLHGSDVMGTSLVLAKAVEKTGYDLVICGMASTDGTMGVLPAILAERLGVPQVTLLSEVSVEDGTVKGRRDGDTASEQLEASLPAVVSVTDQSGEARYPSFKGIMAAKKKPVESLDLEDLEIDAEEVGLEGAWTKVDSAAERPARTAGTIVKDEGEGGKQLAEFLASQKFI
>NZ_CP011340.1|WP_078535538.1|7403706_7404147_-|MarR-family-transcriptional-regulator
MQDFAVLLRRMNGEFNRIAQEFAQSQGLHLTDVQALIAILDGDHADEAGPMTPGRLRKQLNLTSGAMTACLDRLEKAGHIRRVRAADDRRVVHLHYAEGAKQVARDYFQPLARGTDAARGRFTTQELRVVVRFLAEMNRELAALRR
>NZ_CP011340.1|WP_005320549.1|7404275_7406393_+|MMPL-family-transporter
MRSTPRWARWLVPVTLLIVWLGIGGTLGPYAGKLGEVATNDQAAFLPRSAESTKALEAREAFDHAETVPAIVVWTTDGNRVGEAQQATATRVVGELAGRPGIVGRPSPALVSKDGAAMQAVIQLEPDLGDELPAVLDEVRAAAGDVPGATARIAGPAASQADLSDAFAGIDGLLLGVALGAVLLILLLVYRSVLLPFLIILGAVFALGLACAVVYALADRDIVRVDGQVQGILSILVIGAATDYALLLAARFREELAVREDRTAAALAAVRRSFGAITASAATVALGLLALLASDLTNNRALGPVGAIGIVCAVLSTLTFLPAVLVLLGRAAYWPARLKPSDGTAEGHGVWRRVAALVDRRPRRVWVATALVLTAFAAFSPALSSKGVPLDEIFVNDAPSVAAQESLGKHFPGGSGNPAVIIADAERAAQVTAAAEGTEGVASAGAVSASGRPGAGEPLVVDGRVRIDATLEAAADSDAAKDAIERLRENVHAVSGADALVGGYTAQQYDTQQTAARDRTVIVPVVLGIILLILVLLLRSLLVPVLLVATVALNFLATLGVATLVFDLLGFSGTDASVPLYGFVFLVALGVDYNIFLMSRVREEALTHGTRQGVLRGLATTGGVITSAGVVLAATFAALMVIPLAFLVQIAFIVAFGVLLDTLVVRSLLVPALVVDIGPRAWWPSSLAKVATVDSRAGGEAGRTA
>NZ_CP011340.1|WP_053557567.1|7406471_7407374_+|SDR-family-oxidoreductase
MAAKVSPLRGRTAVVTGAARGLGEAVARRLADRGADVALLGREENALARVRDSLTGPGRALCWEVDVTDDAGMARVAAEVRERLGAPSVVVANAGVAEGGPFAESDPATWRRVIEVNLIGSAVTARSFLPALFDTRGFFLQVASLASIGAAPMMSAYCASKAGVESFAHSLRAELAHRQVGVGIAYINWTDTDMIRDADAHAVLRELRGHMPPPARRVYPAAQVAGRLVAAVERRRPTVYMPSWLRATQLVRAAMPPVVTMLSRRELPRLAAAEPFEGTGLLGAGGRADVAPARGSSSGA
>NZ_CP011340.1|WP_005320552.1|7407583_7408957_+|deoxyribodipyrimidine-photo-lyase
MTVAVVLFTSDLRLHDHPPLRAALRAADEVVPLFVLDPGIGAAGFEAPNRCAFLADCLADLDASLRERGGRLVVRSGPVAQQVGAIAAECGAGEVHMAAGVTRYARRREELLRTVLRERGATLRTHDAVITVVAPGAVTPAGSDHYSVFTPYFRRWSQQRLRDPCRAPRTVPVPVTMHGEPLPSRDAVPRISPGLPAGGESAGRKRFHDWEASGLDAYDVQHDSLAGDMTSRLSPYLHFGALSPLELVREASAHGGTGAEAFVRQLCWRDFHHQVMAARPASSVEDYRPRHDRWRTQDDAAEDITAWKEGATGFPVVDAAMRQLRHEGWMHNRARLLVASFLTKTLYVDWRIGARYFLDRLVDGDIVNNQLNWQWVAGTGTDTRPHRVLNPVVQGKRFDPRGEYVRRWVPELREIPDGAVHEPWRLPADRRARLDYPDPLIDLAEGLARFKHARGRI
>NZ_CP011340.1|WP_005320554.1|7409023_7410004_-|MerR-family-transcriptional-regulator
MTSAREDTGESGGLTTGEVARRLGVAPTTVRSWDRRYGLGPDAHTGGKHRRWTAADIARLERMCALTTTGVPPAEAARLAREGAPLDTRQPSAEAAGVSRSGPVRSRARTGLQLGDVRQECKGLARAALRLDAAALDELLASVITAHGLVTAWNEVIMPTLQAVGRKWETSGEKYVEVEHFLSWHVAGALRRGSPPVAAERPGATVVLACVPGESHTLPLEVLAAALAERGLPVRMFGAALPVEALVEAVRRTGPAAVGLWAQSRTTASRPLAQHVAAMEWGVRGARRQPVVLTLGPGWAGRTLPGLLRPTGLVEALAAVESVVRR
>NZ_CP011340.1|WP_005320556.1|7410141_7410756_+|sigma-70-family-RNA-polymerase-sigma-factor
MSTITRPRDHLRPPAEERQQEAELTRGLFAADERVFATIYRQWSPLVRTMATRTLGDAREAEDVTQLVFLAAWRGRSGFRPDKGPLGAWLVGITRRKIVDALAARTRRLRLIDAAADASTATALRRGDAGPDSVLDRVLLADEISRLPLPQRQVLRMAFYEDLTQRQISERTGLPLGTVKSHARRGLHRLRHRIEQNRPSDTDE
>NZ_CP011340.1|WP_037775362.1|7410857_7411676_+|DUF4397-domain-containing-protein
MTSRTPLTLVASAGVCVFALAAAAPAMASSAQDEKAMVSVFHGVPGLDVDVYANGDELLGDFKPGTLTEPQSLAAGTYDIQVFAAGEGPGGTPAVEKSIDVPAGANATIAAHLSADGKPQLTAFVNDMSALEAGKTRLTVRHVAAAPAVDVRAGGQPLFTGLENPKQATTEVDAGAVSADVVLAGTDTVAVGPADLDLKEGTGNVVYAWGSAQDKNLALKVQSFSGMESASGADGAAVPRNSSQPWLASAAAAGVVAVPGLLVARRAAGRRG
>NZ_CP011340.1|WP_005320558.1|7411876_7412311_-|hypothetical-protein
MSSDHERPDSRHRRPSGVTRATVEALGALSKALETTERARGALYSFHQLTGSADLVLDDAVRLLREAGHGREADRVEREVLGRNVIPDHWTFQIIEAYNATYYRPFQQLEEEIRSELADGRDHLYEAEMKEERRTKHHPDHTAC
>NZ_CP011340.1|WP_005320559.1|7412585_7412765_-|hypothetical-protein
MRRTVLEKFPAGDPRGSRQAEEYARHRRDEGLAAEVVMDLDSDAFLVVVPQQQSSERGW
>NZ_CP011340.1|WP_005320560.1|7412924_7413968_+|NUDIX-domain-containing-protein
MIVWINGAFGAGKSTTARELIDLIPNSTLFDPELIGAGMRHLLPAKRLAEVGDYQDLPIWRRLVVDTAAALLAELGGVLVAPMTLLRQDYRDEIFGGLASRRIAVRHVLLAPAETILRERIAAREAFPDDAEESERVRRWAVGNIERYQAALGWLAGDAHVIDTSRLGARAVAAAVADAVRTGAAPASDIVQTPEPAAETLAAGVLLFDEHDRVLLVDPTYKPGWEFPGGVVERGEAPARAGMREVAEELGIELTEVPRLLLVDWEPPAPPGFGGLRLLFDGGRLPEGDAARVLLPGSELRGWKFATEHEAAGMLPPVRYERLRWALRARERGTVLNLEAGVPVGGS

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Crispr_ID: NZ_CP011340_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011340_21

8427407-8427509

Orphan

Consensus_repeat	Method
CGCCGGCCTGATCGTCGACGGCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011340_21

>merge|NZ_CP011340|21|8427407-8427509|CRISPRCasFinder
CGCCGGCCTGATCGTCGACGGCGACACCGGCCCGGCCACGGTGAAGGCCATGCAACGCCACCTCAACACCATGACCGGCGCCGGCCTGACCGTCGACGGCGAC

>NZ_CP011340|21|20|8427407-8427509|CRISPRCasFinder
CGCCGGCCTGATCGTCGACGGCGAC	ACCGGCCCGGCCACGGTGAAGGCCATGCAACGCCACCTCAACACCATGACCGG
CGCCGGCCTGACCGTCGACGGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011340.1\|WP_053556605.1\|8427565_8429422_+\|DUF839-domain-containing-protein	unknown	unknown	gnl\|CDD\|225752
NZ_CP011340.1\|WP_005322090.1\|8420691_8421399_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213984
NZ_CP011340.1\|WP_005322079.1\|8416787_8417378_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP011340.1\|WP_005322101.1\|8429485_8429872_-\|glyoxalase/bleomycin-resistance/dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|319925
NZ_CP011340.1\|WP_005322116.1\|8437008_8437932_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP011340.1\|WP_005322109.1\|8433111_8434128_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP011340.1\|WP_158685257.1\|8431984_8432149_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011340.1\|WP_005322097.1\|8424840_8425260_+\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP011340.1\|WP_106428503.1\|8430732_8431950_+\|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|366736
NZ_CP011340.1\|WP_005322087.1\|8418314_8419589_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129987
NZ_CP011340.1\|WP_005322088.1\|8419786_8420092_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367559
NZ_CP011340.1\|WP_005322111.1\|8434411_8435728_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP011340.1\|WP_037777449.1\|8422636_8423503_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|223532
NZ_CP011340.1\|WP_037775665.1\|8416256_8416688_-\|4-oxalocrotonate-tautomerase	unknown	unknown	gnl\|CDD\|224853
NZ_CP011340.1\|WP_037775668.1\|8432261_8432876_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|223340
NZ_CP011340.1\|WP_005322092.1\|8421695_8422457_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_CP011340.1\|WP_005322096.1\|8423646_8424663_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238042
NZ_CP011340.1\|WP_005322104.1\|8430179_8430383_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP011340.1\|WP_086025621.1\|8435896_8437012_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NZ_CP011340.1\|WP_037775666.1\|8420160_8420607_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759

Protein	Function_ID	Function_description	E-value
NZ_CP011340.1\|WP_053556605.1\|8427565_8429422_+\|DUF839-domain-containing-protein	gnl\|CDD\|225752	COG3211, PhoX, Predicted phosphatase [General function prediction only].	3.91529e-140
NZ_CP011340.1\|WP_005322090.1\|8420691_8421399_+\|hypothetical-protein	gnl\|CDD\|213984	cd12109, Hr_FBXL5, Hemerythrin-like domain of FBXL5-like proteins. Human FBXL5 (F-box and leucine-rich repeat protein 5) protein plays a role in cellular iron homeostasis. It is part of an E3 ubiquitin ligase complex that targets the iron regulatory protein IRP2 for proteasomal degradation. The FBXL5's stability is regulated by iron concentration, with its iron- and oxygen-binding hemerythrin domain acting as a ligand-dependent regulatory switch.	5.84411e-50
NZ_CP011340.1\|WP_005322079.1\|8416787_8417378_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.66426e-09
NZ_CP011340.1\|WP_005322101.1\|8429485_8429872_-\|glyoxalase/bleomycin-resistance/dioxygenase-family-protein	gnl\|CDD\|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.88115e-18
NZ_CP011340.1\|WP_005322116.1\|8437008_8437932_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.56568e-77
NZ_CP011340.1\|WP_005322109.1\|8433111_8434128_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.89695e-112
NZ_CP011340.1\|WP_037775668.1\|8432261_8432876_-\|DNA-binding-protein	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	7.69353e-15
NZ_CP011340.1\|WP_005322097.1\|8424840_8425260_+\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	4.78793e-10
NZ_CP011340.1\|WP_106428503.1\|8430732_8431950_+\|aminoglycoside-phosphotransferase-family-protein	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	1.41298e-11
NZ_CP011340.1\|WP_005322087.1\|8418314_8419589_+\|amino-acid-permease	gnl\|CDD\|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.21435e-48
NZ_CP011340.1\|WP_005322088.1\|8419786_8420092_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	5.85406e-21
NZ_CP011340.1\|WP_005322111.1\|8434411_8435728_+\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.12755e-28
NZ_CP011340.1\|WP_037777449.1\|8422636_8423503_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|223532	COG0456, RimI, Acetyltransferases [General function prediction only].	1.59872e-06
NZ_CP011340.1\|WP_037775665.1\|8416256_8416688_-\|4-oxalocrotonate-tautomerase	gnl\|CDD\|224853	COG1942, COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only].	3.81304e-06
NZ_CP011340.1\|WP_005322092.1\|8421695_8422457_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	1.19079e-38
NZ_CP011340.1\|WP_005322096.1\|8423646_8424663_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.57682e-09
NZ_CP011340.1\|WP_005322104.1\|8430179_8430383_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.65858e-36
NZ_CP011340.1\|WP_086025621.1\|8435896_8437012_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.86743e-80
NZ_CP011340.1\|WP_037775666.1\|8420160_8420607_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.00388e-09

>NZ_CP011340.1|WP_005322097.1|8424840_8425260_+|peptidoglycan-binding-protein
MRRPTKLAAVTAVIGTALLAPAGPAAAAPPAAATAGIQAYSCDVTTTGDKLYAGYYSGESVTPSSTSVTAAGKEAQCLLRKRGFDPGTVDGIFGSNSQTAAKKFQLYVNGRCGRAVLDVDGKVGPRTWPYLRQVAFCFE
>NZ_CP011340.1|WP_005322096.1|8423646_8424663_-|helix-turn-helix-transcriptional-regulator
MLRIHFTDADLARTRVAAAPDPLWEICTSLHRFQSRQGRWAYADWHRTARAQLHATGFVRTLRTLLLPLVPRAAYFPDFLTPPESAGGLDAGLEAILATPKHRVMEEVGILAHTSGAPSWAPRLTEPGFREDLVKAMRTYHDTVIAPHHDVIQARIEAERSACARAVLDDGVEGILRNLGAPVLQWRRPVLHTVYPEDRDLRLDGRGLLLVPSYFCWGNPVTFGDTAHDPVLIYALNHEPHPATLKEEFSSGASLAALLGRTRAAVLRAAAVGATTGELARAVGVSAPSASQHARALRDAGLVTSRRNAASVLHTLTPLGAALLRANRRRGSNEGAQR
>NZ_CP011340.1|WP_037777449.1|8422636_8423503_-|GNAT-family-N-acetyltransferase
MAIVLGTPEVDGLGEAVGVLREWQYEGAPMQLHPGDLGWFWRSGAEATAAAVRTWRRDGRILAVGLLDGPGLLRLTIAPDARQDEELARQLAEDVSGPERGVLPAGKVNVEAPVGALVQDLLSEDGWGTDEPWTPLRRDLTEPVKDPGVRIEVVGPEQAHVFATALRAAFDGSRFTAERWHAMAAGLPYADARCLVAYDEAGGAAAVVTVWSAGPGRPGLLEPMGVHREHRRRGYGVAVTVAAAAALEELGSSSAIVCTPSSNAGAVATYRSAGFRPRPEVRDRYRDA
>NZ_CP011340.1|WP_005322092.1|8421695_8422457_+|MerR-family-transcriptional-regulator
MDWPIAEVARMSGVTARTLRHYDEIGLLPPARTGANGHRYYEENQLLLLQQILVLRALGLGLPEIGRILAEQVDEVEALRGHHRRLLAERDRLEALAGTVRRTIAELEKSRKDGTPMTAINRPENLFEGVRPAQYEESLHDFPEHAEAIARKVAAMTEQDVEAGQRERTAQMIRLAELMAGGHPADAEPVQAEADAQYRALSELRAVSAEEYRAIGRSCVDNDAWRAAYEAIAPGLAAYQRDAIEAYAATRLS
>NZ_CP011340.1|WP_005322090.1|8420691_8421399_+|hypothetical-protein
MPRIDLYRTVHMGQRERLFALAVETGAADTAEPECAGHLAKRCLAMTQELREHADHEDRFIHPLLRERAPEAADALDAEHVRLDAALTALDDRARRLPTTPAGSLPDAQHGLYLAVNELISAYLAHLHAEETVAMPALWDRCSDAELGEVFAAFKASRTPEESLADLRGMLPSLPPAVRTAIVRATLEAAPDDDAGRTLAAVSTTLDPRRRSRLYDDLGAPEAWALVESEREQAH
>NZ_CP011340.1|WP_037775666.1|8420160_8420607_-|winged-helix-turn-helix-transcriptional-regulator
MSDEMALLVADVFEAAGALRRLGEHTAQAEGLTQARWQVLSVVSETALTVPQAARRLGVSRQNVQRVANDLVTFGHAAYTANPDHRGSPLLALTPQGQEVLARVTTRASAVHRTLFAALPEEEIGRTRGLLRRLLEELDRREQADGRR
>NZ_CP011340.1|WP_005322088.1|8419786_8420092_-|helix-turn-helix-transcriptional-regulator
MREFQRGAVRLHILHHAAEEEIHGAWMTEELASHGYRISPGTLYPTLHRLEADGLLVSEQRVVDGRARRVYRATEAGRRALAEDRRALRELAREVLGDDAP
>NZ_CP011340.1|WP_005322087.1|8418314_8419589_+|amino-acid-permease
MSKPPAAAGVPDELRRRLGVPDAVMIGLGAMIGAGIFAALAPAAQAAGSGLLIGLALAAVVAYCNATSSARLAARYPASGGTYVYGRERLGDFWGYLAGWGFIVGKTASCAAMALTVGSYVWPGQAHAVAVAAVVALTVVNYAGVQKSAVLTRVIVAVVLAVLAAVVVAALTSGAFDPARLGIGDDATVGGVLQAAGLLFFAFAGYARIATLGEEVRDPARTIPLAVPVALGITLVVYAAVAVAVLTVLGPEGLARAAAPLSDAARAAGADRLVPVVRAGAALAALGSLLALILGVSRTTLAMARDRHLPHALAAVHPRFKVPHRAELAVGAVVAVLAATADVRGAIGFSSFGVLAYYAVANASAWTLSAEEGRPARIVPVVGLAGCLVLAFALPLSSVISGAVVLALGAAAYAVRRKVAARTS
>NZ_CP011340.1|WP_005322079.1|8416787_8417378_+|TetR/AcrR-family-transcriptional-regulator
MVRSSSGTQSRERIVAGAADMISRRGLSATSIREMAKHAEAPLGSTYHYFPEGKQQLAAEAVRHTGEWVARALRKELEAGPAAGLRAFLALWRKIVVDTDFHAGCPVLAVAIEEPPADEVPPALAAAAEVFDRWEGLLADSLREHGADAEQAAQVATLIVAAVEGTVALCRAKRSTEPLDRTAAQLQALIATTISG
>NZ_CP011340.1|WP_037775665.1|8416256_8416688_-|4-oxalocrotonate-tautomerase
MPMIRLTVPTGALTGQGRATVQRDLAAVLLRWEGAPDTAFFRAQAWSYLTELPGGAQVTAEDDAPRFLVEVTVPQGALSERRKAGLAREATATVLAAAGLSPAEAPRVWVLVNEQPDGTWGAGGSVVRYADLVALAKGRQADA
>NZ_CP011340.1|WP_053556605.1|8427565_8429422_+|DUF839-domain-containing-protein
MRDDRHADADTARPDATGPSRRNIVAGGALAAAGLLVLGAPQAAAAPSAGRSATARRPLAPFTAVAASESDTVTVPTGCTATVLAPWGRPIRASGPRWRTDAGDTAAEQAQQVGSHHHGVQFFPLADGAAGNRHGLLVIGHEATDPDLLGGGADKAIAAQGLTVLEVRRSAGTWQAVDSARNRRVTGDTPVRFSGPVAVDGRPRGVLACSGHGITPWGTYLAAEENVNAAFGTDDPHWRRDEQHVRYGLSANGFGHPWHHFDARFDLAAPEARPEEFGWIVELDPHDPSALPVKRTALGRFAHGSATVTETAGRLVLHSTDAEDGGHLYKFVSSDNWRRLRDLGRSPLDHGTLYAARISPDGTGRWLPLTHGHGPLTRANGWHDQADVLVRARTAADALGATPLARPERVAVSPLDGRVYLALANSTGSSPCAGEAANGTTHTPCARSADPYGRVIRWRESEATPDRDGDGATPLSFHWEEFLTPDDPALRADGAFAAPKGLWFGADGTLWISTGVSGHTLNGPDDIHRTAGNNALLAADPTTKEVRRFLTAPRGAEVTGVTSTPDGQTLFVNIQHPGERTARWGAPGPDNPRAVSNWPDHSRNGRPRSATVAVHRTT
>NZ_CP011340.1|WP_005322101.1|8429485_8429872_-|glyoxalase/bleomycin-resistance/dioxygenase-family-protein
MVHVLGSRVLLRPTDPDRSRAFYGGALGLAVSREFGTGPERGTVYFLGGGFLEVSGRSENPPAPGLGLWLQVEDVQAAFEELRAAGVEVLRAPVMEPWGLIEMWIADPDGVRIAVVEVPENHPLRYRP
>NZ_CP011340.1|WP_005322104.1|8430179_8430383_-|cold-shock-protein
MATGTVKWFNPEKGFGFIEQDGGGPDVFVHYSAIASTGFRELFEGQKVQFDVTQGPKGPQAENVTPA
>NZ_CP011340.1|WP_106428503.1|8430732_8431950_+|aminoglycoside-phosphotransferase-family-protein
MDGGSRAAQRCLYRTTRTKSVRDTPVAPGPTAPDTRAPTGAQRRRPCPPGRARTSRRCAVNAPAKPSGTTYERAVHRLRRALGPVDVAGGRALTGGLYNCVHLFELADGRRLVLKSAPSAEAPALTHERQLLGTETIFHRLAATKGVSVPTVLHYEPAGPDDPGEWLLLDFLADSTWSEVGEDLPADGRPALRHRLGSALARTATATGPRFGYPQPVPGLQGDTWLEAFTGMMHAVLKDASRFGSPLPAATDTLAALPDRFADALDEVSRPALVHFDAWEGNVILTRDGDGGWRFGGLIDGERAFFGDPLAELVGLDPLGAAEDDPDLMAGYRSVTSDLPTTTPAARSRLALYRIYLALIMRVESIPRAYGPEHSAWLRSWSTERITQQLAVLDRLAAGQRLPSP
>NZ_CP011340.1|WP_158685257.1|8431984_8432149_+|hypothetical-protein
MGLTLRPAEAGPWLQLGNWPVLFDTASPLPSDMDGSWVEISVEADHVAVHPYRT
>NZ_CP011340.1|WP_037775668.1|8432261_8432876_-|DNA-binding-protein
MTRIIADISVSLDGFVTGPDPGPDNGLGTGGEALHTWAFSDDPDDRRVLREATVRSGAVVLGRRLFDVVDGPNGWDDTTGYGAGEVGKPAFVVVTSSPPESVRLTGLDWTFVTTGLPDAVAAARERAEAASSDSGKDLDVVLMGGGATVASALDAGLVDELTLHLAPVVLGAGTPLFTGVARRALVQRSVTSTSTATHLTYDVL
>NZ_CP011340.1|WP_005322109.1|8433111_8434128_-|LacI-family-transcriptional-regulator
MGGSRRPTIKTVAARAGVGRTTVSRVINGSPLVSDEARDAVLAAISELGYVPNSVARGLVTSRTDSIALVIPESESRLGSEPYFSAVIRGVSTGLADTRTQLQLVLVRDKGEQDQLTDSVAARRVDGVLLVSVHERDPLPGLLEDMGLPTVLAGRRSPAESLSHAHSDNVGGAAAAVRHLVERGRETITTITGPLDMDVGRSRLRGWREALDAAGRDSGEHLVAAADFTEEGGRQAMRSLLERVPGLDAVFAASDVMAVGAMTELRAQGRRIPQDVAVIGFDDSFIARHTDPPLTTVRQPVEEIGRTIARILLAEIVDPDAPRQHVVLPTELVVRDST
>NZ_CP011340.1|WP_005322111.1|8434411_8435728_+|extracellular-solute-binding-protein
MSRNQKLLRTRITGAVSAVAALGLIVGCSGGGGDSGTGGGVKDGKVTITMGLFGVMGYKETGLLDRYMKENPNVTIKAEVAGDEQTYYTALQTHLAAGSGLKDIQGIEIGRAKELVDTQADKFVDLAGVPGIDHYLPWKLSQVTTPDKKLIGLGTDIGPMAVCYRKDLFEQAGLPTDRNEVAKLWAGDWSKYVQAGKDFKAGFKGDGVAFMDSASGLFNAMIYGNSEQFYDKDGKLIYRDSPTVTGAWDLASQAATSGLTAKLRQFQPGWDPGLANSTFATTVCPAWMLGHITEKAGPKNKGKWDVAKAPKGANWGGSFLGVMEQSPVKEEAKKLVAWLTAPEQQEFVFQKLGNFPSSQKALTSPAVTGAKQEYFGNAPIGEIFGAAAQEIPDEQVLGRKDGTIKDIFSQGLTLIESQNKSPEEAWKTTDERIEKATG
>NZ_CP011340.1|WP_086025621.1|8435896_8437012_+|ABC-transporter-permease-subunit
MHGTGPRSLIRPDPNDRPRPSTSRPHRKAVPVAASTPVAPAGGPAGKHPAPGAPEDSAPPRRRALLHRLDVRGAPYAFVAPFFIVFAAFSFYPLVYTSWISLHRVELATMNVMEWVAFDNYVALWEDERFWNAVGNTITLGVISTVPQLLMALGLAHLLNYRMRGSTFFRVAALTPYATSVGAAALVFTMLFERDFGMINWMLGLFGFDNVDFENNKWAAQIAISTIVIWRWTGYNALLYLAAMQAVPRERYEAAAIDGASRWQQFLTVTVPGIRSTIVFTIVLSTIGATQLFGEPLIFGQGPNGITGGADNQYQTLGLLLYEEGWKNYQMGRAATVAWVMFLLLVLVFVIQRVVRRAASRRSAPTRSTAS
>NZ_CP011340.1|WP_005322116.1|8437008_8437932_+|carbohydrate-ABC-transporter-permease
MTTDSLPARAEPRPGDVQKSTGRTRRRPTLRIRAGRQHHAGPLAYVLLAIAALTSLFPLYWTMVAASTDNTRVTQTPPPLLPGPNLFENLARAWDEAAMGKAMINSLIVAGCIALATVLFATLAGFAFAKLRFKARNVLLMLVIGTMMVPPQLSVVPLFMMMSDLGWGQKLPAVIFPTLVSAVGVFFMRQYLAEALPDELVEAGRVDGAHSLRIFWSIVLPIARPAMSVLFMITFVHAWNDFFWPFIALDMSNPTVPVALTQLSAGYIRDQSLIMAGALLGTLPLLAMFVVFGRQIVGGIMQGAVKG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP011340_2	2.1\|288885\|49\|NZ_CP011340\|CRISPRCasFinder	288885-288933	49	NZ_CP011340.1	8243660-8243708	0	1.0

1. spacer 2.1|288885|49|NZ_CP011340|CRISPRCasFinder matches to position: 8243660-8243708, mismatch: 0, identity: 1.0

gctggtaccgcgtcgtgctcgtggtgcgggaccgcgttccgctcgtggt	CRISPR spacer
gctggtaccgcgtcgtgctcgtggtgcgggaccgcgttccgctcgtggt	Protospacer
*************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP011340_18	18.1\|6162797\|24\|NZ_CP011340\|CRISPRCasFinder	6162797-6162820	24	NZ_CP009431	Sphingopyxis macrogoltabida strain 203 plasmid unnamed, complete sequence	82738-82761	2	0.917
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP015094	Pelagibaca abyssi strain JLT2014 plasmid pPABY6, complete sequence	30671-30697	2	0.926
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP013536	Rhizobium phaseoli strain R650 plasmid pRphaR650d, complete sequence	790142-790168	2	0.926
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP013546	Rhizobium phaseoli strain R620 plasmid pRphaR620d, complete sequence	123833-123859	2	0.926
NZ_CP011340_18	18.1\|6162797\|24\|NZ_CP011340\|CRISPRCasFinder	6162797-6162820	24	NZ_LR134446	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 4, complete sequence	71167-71190	3	0.875
NZ_CP011340_18	18.1\|6162797\|24\|NZ_CP011340\|CRISPRCasFinder	6162797-6162820	24	NZ_CP009336	Bacillus thuringiensis strain HD1011 plasmid 1, complete sequence	71390-71413	3	0.875
NZ_CP011340_18	18.1\|6162797\|24\|NZ_CP011340\|CRISPRCasFinder	6162797-6162820	24	NZ_CP015601	Pseudomonas antarctica strain PAMC 27494 plasmid pP27494_1, complete sequence	117203-117226	3	0.875
NZ_CP011340_18	18.1\|6162797\|24\|NZ_CP011340\|CRISPRCasFinder	6162797-6162820	24	MH479924	Gordonia phage Rofo, complete genome	19941-19964	3	0.875
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP035420	Leisingera sp. NJS204 plasmid unnamed3, complete sequence	116595-116621	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP035420	Leisingera sp. NJS204 plasmid unnamed3, complete sequence	115758-115784	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP031958	Phaeobacter sp. LSS9 plasmid unnamed2, complete sequence	18019-18045	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP010678	Phaeobacter gallaeciensis strain P75 plasmid pP75_e, complete sequence	63172-63198	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_023142	Phaeobacter gallaeciensis DSM 26640 plasmid pGal_F69, complete sequence	63201-63227	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP010789	Phaeobacter gallaeciensis strain P63 plasmid pP63_e, complete sequence	63166-63192	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_010580	Beijerinckia indica subsp. indica ATCC 9039 plasmid pBIND01, complete sequence	22520-22546	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP010660	Phaeobacter piscinae strain P71 plasmid pP71_d, complete sequence	63162-63188	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP010642	Phaeobacter gallaeciensis strain P73 plasmid pP73_f, complete sequence	63172-63198	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP010773	Phaeobacter piscinae strain P13 plasmid pP13_f, complete sequence	63632-63658	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP010648	Phaeobacter piscinae strain P36 plasmid pP36_e, complete sequence	63598-63624	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP010593	Phaeobacter gallaeciensis strain P11 plasmid pP11_e, complete sequence	63198-63224	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP026928	Agrobacterium tumefaciens strain 1D1609 plasmid pAt1D1609b, complete sequence	104493-104519	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP015747	Shinella sp. HZN7 plasmid pShin-11, complete sequence	29900-29926	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_021911	Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1f, complete sequence	163567-163593	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_021911	Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1f, complete sequence	164536-164562	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_006569	Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence	167349-167375	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_010997	Rhizobium etli CIAT 652 plasmid pC, complete sequence	896728-896754	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_010997	Rhizobium etli CIAT 652 plasmid pC, complete sequence	899249-899275	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_010997	Rhizobium etli CIAT 652 plasmid pC, complete sequence	900218-900244	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_007949	Polaromonas sp. JS666 plasmid 1, complete sequence	26041-26067	3	0.889
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_007949	Polaromonas sp. JS666 plasmid 1, complete sequence	27631-27657	3	0.889
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	NZ_CP021653	Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence	781675-781701	4	0.852
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	NZ_CP012688	Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence	781682-781708	4	0.852
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	CP047139	Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence	798051-798077	4	0.852
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	CP047137	Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence	761341-761367	4	0.852
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	NZ_CP007796	Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence	55424-55450	4	0.852
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP015747	Shinella sp. HZN7 plasmid pShin-11, complete sequence	15907-15933	4	0.852
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP015234	Epibacterium mobile F1926 plasmid unnamed4, complete sequence	10299-10325	4	0.852
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP015234	Epibacterium mobile F1926 plasmid unnamed4, complete sequence	45056-45082	4	0.852
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_021911	Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1f, complete sequence	166084-166110	4	0.852
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP010732	Phaeobacter inhibens strain P88 plasmid pP88_g, complete sequence	64564-64590	4	0.852
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP032687	Rhizobium sp. CCGE531 plasmid pRCCGE531b, complete sequence	507347-507373	4	0.852
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP021045	Phaeobacter gallaeciensis strain P129 plasmid pP129_e, complete sequence	63076-63102	4	0.852
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP010685	Phaeobacter piscinae strain P14 plasmid pP14_d, complete sequence	62915-62941	4	0.852
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP032696	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525b, complete sequence	2919-2945	4	0.852
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP024313	Rhizobium sp. NXC24 plasmid pRspNXC24b, complete sequence	375639-375665	4	0.852
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP034347	Roseovarius sp. MME-070 plasmid pMME07001, complete sequence	52437-52463	4	0.852
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP049248	Rhizobium rhizoryzae strain DSM 29514 plasmid unnamed2, complete sequence	22338-22364	4	0.852
NZ_CP011340_5	5.1\|1901043\|26\|NZ_CP011340\|CRT	1901043-1901068	26	NZ_CP034156	Rhodococcus sp. NJ-530 plasmid unnamed4, complete sequence	63131-63156	5	0.808
NZ_CP011340_5	5.2\|1901091\|31\|NZ_CP011340\|CRT	1901091-1901121	31	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	1407230-1407260	5	0.839
NZ_CP011340_5	5.3\|1901144\|27\|NZ_CP011340\|CRT	1901144-1901170	27	MN329675	Microbacterium phage SansAfet, complete genome	36162-36188	5	0.815
NZ_CP011340_5	5.3\|1901144\|27\|NZ_CP011340\|CRT	1901144-1901170	27	NC_018022	Mycolicibacterium chubuense NBB4 plasmid pMYCCH.01, complete sequence	546558-546584	5	0.815
NZ_CP011340_14	14.1\|5128905\|29\|NZ_CP011340\|CRISPRCasFinder	5128905-5128933	29	NC_011758	Methylorubrum extorquens CM4 plasmid pCMU01, complete sequence	149755-149783	5	0.828
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	NZ_CP040723	Rhodococcus pyridinivorans strain YF3 plasmid unnamed4, complete sequence	96527-96553	5	0.815
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	NZ_CP016820	Rhodococcus sp. p52 plasmid pDF02, complete sequence	9873-9899	5	0.815
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	NZ_CP016820	Rhodococcus sp. p52 plasmid pDF02, complete sequence	149359-149385	5	0.815
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	NC_014309	Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome	771981-772007	5	0.815
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	NZ_CP027023	Streptomyces sp. WAC00288 plasmid p1, complete sequence	110878-110904	5	0.815
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	NC_013857	Azospirillum sp. B510 plasmid pAB510c, complete sequence	567222-567248	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP015234	Epibacterium mobile F1926 plasmid unnamed4, complete sequence	12424-12450	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_021909	Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1e, complete sequence	169228-169254	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_021909	Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1e, complete sequence	517263-517289	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP021031	Rhizobium sp. NXC14 plasmid pRspNXC14a, complete sequence	182304-182330	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP020910	Rhizobium etli strain NXC12 plasmid pRetNXC12d, complete sequence	369019-369045	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP018229	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence	535377-535403	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_HG938354	Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence	580415-580441	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_HG938354	Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence	582242-582268	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_011368	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence	794695-794721	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP025431	Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence	253614-253640	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP025431	Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence	254499-254525	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP021830	Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence	649798-649824	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP023072	Sinorhizobium fredii CCBAU 83666 plasmid pSF83666a, complete sequence	379477-379503	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP014598	Yangia sp. CCB-MM3 plasmid unnamed2, complete sequence	74121-74147	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP017104	Rhizobium gallicum strain IE4872 plasmid pRgalIE4872c, complete sequence	115734-115760	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	CP006879	Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602b, complete sequence	116203-116229	5	0.815
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP041045	Paracoccus sp. AK26 plasmid pAK1, complete sequence	280920-280946	5	0.815
NZ_CP011340_5	5.2\|1901091\|31\|NZ_CP011340\|CRT	1901091-1901121	31	NZ_CP040720	Rhodococcus pyridinivorans strain YF3 plasmid unnamed1, complete sequence	239407-239437	6	0.806
NZ_CP011340_5	5.2\|1901091\|31\|NZ_CP011340\|CRT	1901091-1901121	31	NZ_CP016821	Rhodococcus sp. p52 plasmid pDF01, complete sequence	81167-81197	6	0.806
NZ_CP011340_5	5.3\|1901144\|27\|NZ_CP011340\|CRT	1901144-1901170	27	NZ_CP044217	Mesorhizobium sp. NIBRBAC000500504 plasmid unnamed, complete sequence	121750-121776	6	0.778
NZ_CP011340_14	14.1\|5128905\|29\|NZ_CP011340\|CRISPRCasFinder	5128905-5128933	29	KT221034	Streptomyces phage SF3, complete genome	34418-34446	6	0.793
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	50414-50440	6	0.778
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	MH727561	Mycobacterium phage Serendipitous, complete genome	67172-67198	6	0.778
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	MF417927	Uncultured Caudovirales phage clone 9F_2, partial genome	19257-19283	6	0.778
NZ_CP011340_18	18.4\|6162935\|30\|NZ_CP011340\|CRISPRCasFinder	6162935-6162964	30	MN856022	Bacteriophage sp. isolate 138, complete genome	9030-9059	6	0.8
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP025013	Rhizobium leguminosarum strain Norway plasmid pRLN1, complete sequence	298306-298332	6	0.778
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NC_021240	Paracoccus marcusii strain DSM 11574 plasmid pMARC3, complete sequence	4194-4220	6	0.778
NZ_CP011340_20	20.4\|7402879\|27\|NZ_CP011340\|CRISPRCasFinder	7402879-7402905	27	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1412063-1412089	6	0.778
NZ_CP011340_5	5.2\|1901091\|31\|NZ_CP011340\|CRT	1901091-1901121	31	NZ_CP033584	Streptomyces sp. ADI95-16 plasmid pADI95-16c, complete sequence	2889-2919	7	0.774
NZ_CP011340_5	5.2\|1901091\|31\|NZ_CP011340\|CRT	1901091-1901121	31	NZ_CP012477	Arthrobacter sp. ERGS1:01 isolate water plasmid unnamed2, complete sequence	321093-321123	7	0.774
NZ_CP011340_5	5.2\|1901091\|31\|NZ_CP011340\|CRT	1901091-1901121	31	NZ_CP032325	Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence	98842-98872	7	0.774
NZ_CP011340_9	9.2\|3409702\|27\|NZ_CP011340\|CRISPRCasFinder	3409702-3409728	27	NZ_CP029179	Acidibrevibacterium fodinaquatile strain G45-3 plasmid unnamed3, complete sequence	6173-6199	7	0.741
NZ_CP011340_9	9.2\|3409702\|27\|NZ_CP011340\|CRISPRCasFinder	3409702-3409728	27	NZ_CP034352	Streptomyces sp. W1SF4 plasmid p2, complete sequence	164826-164852	7	0.741
NZ_CP011340_14	14.1\|5128905\|29\|NZ_CP011340\|CRISPRCasFinder	5128905-5128933	29	NZ_CP029830	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed1, complete sequence	547515-547543	7	0.759
NZ_CP011340_18	18.2\|6162845\|27\|NZ_CP011340\|CRISPRCasFinder	6162845-6162871	27	MN908685	Microbacterium phage PauloDiaboli, complete genome	101705-101731	7	0.741
NZ_CP011340_18	18.4\|6162935\|30\|NZ_CP011340\|CRISPRCasFinder	6162935-6162964	30	NZ_CP025013	Rhizobium leguminosarum strain Norway plasmid pRLN1, complete sequence	780045-780074	7	0.767
NZ_CP011340_18	18.4\|6162935\|30\|NZ_CP011340\|CRISPRCasFinder	6162935-6162964	30	NZ_CP048281	Rhizobium leguminosarum bv. viciae 248 plasmid pRle248e, complete sequence	434968-434997	7	0.767
NZ_CP011340_5	5.2\|1901091\|31\|NZ_CP011340\|CRT	1901091-1901121	31	NC_015724	Cupriavidus necator N-1 plasmid pBB2, complete sequence	52820-52850	8	0.742
NZ_CP011340_5	5.2\|1901091\|31\|NZ_CP011340\|CRT	1901091-1901121	31	NZ_CP045095	Streptomyces sp. GY16 plasmid unnamed1, complete sequence	15225-15255	8	0.742
NZ_CP011340_5	5.2\|1901091\|31\|NZ_CP011340\|CRT	1901091-1901121	31	LN997843	Streptomyces reticuli genome assembly TUE45, plasmid : II	580949-580979	8	0.742
NZ_CP011340_5	5.2\|1901091\|31\|NZ_CP011340\|CRT	1901091-1901121	31	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	2396828-2396858	8	0.742
NZ_CP011340_5	5.2\|1901091\|31\|NZ_CP011340\|CRT	1901091-1901121	31	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	47942-47972	8	0.742
NZ_CP011340_5	5.2\|1901091\|31\|NZ_CP011340\|CRT	1901091-1901121	31	MK112530	Mycobacterium phage BigPaolini, complete genome	4864-4894	8	0.742
NZ_CP011340_18	18.4\|6162935\|30\|NZ_CP011340\|CRISPRCasFinder	6162935-6162964	30	MN204493	Streptomyces phage Zuko, complete genome	37831-37860	8	0.733
NZ_CP011340_18	18.4\|6162935\|30\|NZ_CP011340\|CRISPRCasFinder	6162935-6162964	30	NZ_CP029209	Nitratireductor sp. OM-1 plasmid pOM-1, complete sequence	284590-284619	8	0.733
NZ_CP011340_13	13.1\|4616399\|38\|NZ_CP011340\|CRISPRCasFinder	4616399-4616436	38	NZ_CP029452	Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence	2177418-2177455	10	0.737
NZ_CP011340_13	13.1\|4616399\|38\|NZ_CP011340\|CRISPRCasFinder	4616399-4616436	38	NZ_CP023071	Sinorhizobium fredii CCBAU 83666 plasmid pSF83666b, complete sequence	2243722-2243759	10	0.737

1. spacer 18.1|6162797|24|NZ_CP011340|CRISPRCasFinder matches to NZ_CP009431 (Sphingopyxis macrogoltabida strain 203 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.917

cgttgttgccgtcgttcccgttgt	CRISPR spacer
cgtagttgccgtcgttcacgttgt	Protospacer
*** ************* ******

2. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP015094 (Pelagibaca abyssi strain JLT2014 plasmid pPABY6, complete sequence) position: , mismatch: 2, identity: 0.926

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
aaccgccgtcgatcgagtcgttgccgg	Protospacer
 ******************.*******

3. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP013536 (Rhizobium phaseoli strain R650 plasmid pRphaR650d, complete sequence) position: , mismatch: 2, identity: 0.926

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccgtcaatcgagtcattgccga	Protospacer
**********.***************.

4. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP013546 (Rhizobium phaseoli strain R620 plasmid pRphaR620d, complete sequence) position: , mismatch: 2, identity: 0.926

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccgtcaatcgagtcattgccga	Protospacer
**********.***************.

5. spacer 18.1|6162797|24|NZ_CP011340|CRISPRCasFinder matches to NZ_LR134446 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 4, complete sequence) position: , mismatch: 3, identity: 0.875

cgttgttgccgtcgttcccgttgt	CRISPR spacer
cgttgttgccgccgtgcccgttga	Protospacer
***********.*** *******

6. spacer 18.1|6162797|24|NZ_CP011340|CRISPRCasFinder matches to NZ_CP009336 (Bacillus thuringiensis strain HD1011 plasmid 1, complete sequence) position: , mismatch: 3, identity: 0.875

cgttgttgccgtcgttcccgttgt	CRISPR spacer
cgttgttcccgtcgctcccgttgc	Protospacer
******* ******.********.

7. spacer 18.1|6162797|24|NZ_CP011340|CRISPRCasFinder matches to NZ_CP015601 (Pseudomonas antarctica strain PAMC 27494 plasmid pP27494_1, complete sequence) position: , mismatch: 3, identity: 0.875

cgttgttgccgtcgttcccgttgt	CRISPR spacer
tgttgttgccgttgttgccgttgt	Protospacer
.***********.*** *******

8. spacer 18.1|6162797|24|NZ_CP011340|CRISPRCasFinder matches to MH479924 (Gordonia phage Rofo, complete genome) position: , mismatch: 3, identity: 0.875

cgttgttgccgtcgttcccgttgt	CRISPR spacer
cgttgttgccgtcgttgccggtgg	Protospacer
**************** *** **

9. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP035420 (Leisingera sp. NJS204 plasmid unnamed3, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
aactgccgtcgatcgtgtcattgccgg	Protospacer
 **.*********** ***********

10. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP035420 (Leisingera sp. NJS204 plasmid unnamed3, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cattgccgtcgatcgtgtcattgccgg	Protospacer
**..*********** ***********

11. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP031958 (Phaeobacter sp. LSS9 plasmid unnamed2, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccatcgatccagtcattgccgt	Protospacer
*******.****** ***********

12. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP010678 (Phaeobacter gallaeciensis strain P75 plasmid pP75_e, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccatcgatccagtcattgccgt	Protospacer
*******.****** ***********

13. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_023142 (Phaeobacter gallaeciensis DSM 26640 plasmid pGal_F69, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccatcgatccagtcattgccgt	Protospacer
*******.****** ***********

14. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP010789 (Phaeobacter gallaeciensis strain P63 plasmid pP63_e, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccatcgatccagtcattgccgt	Protospacer
*******.****** ***********

15. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_010580 (Beijerinckia indica subsp. indica ATCC 9039 plasmid pBIND01, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
gacccccgtcgatcgtgtcattgccgg	Protospacer
 *** ********** ***********

16. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP010660 (Phaeobacter piscinae strain P71 plasmid pP71_d, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccatcgatccagtcattgccgt	Protospacer
*******.****** ***********

17. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP010642 (Phaeobacter gallaeciensis strain P73 plasmid pP73_f, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccatcgatccagtcattgccgt	Protospacer
*******.****** ***********

18. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP010773 (Phaeobacter piscinae strain P13 plasmid pP13_f, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccatcgatccagtcattgccgt	Protospacer
*******.****** ***********

19. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP010648 (Phaeobacter piscinae strain P36 plasmid pP36_e, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccatcgatccagtcattgccgt	Protospacer
*******.****** ***********

20. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP010593 (Phaeobacter gallaeciensis strain P11 plasmid pP11_e, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccatcgatccagtcattgccgt	Protospacer
*******.****** ***********

21. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP026928 (Agrobacterium tumefaciens strain 1D1609 plasmid pAt1D1609b, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
ctccgccgtcgatcttgtcattgccgg	Protospacer
* ************  ***********

22. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP015747 (Shinella sp. HZN7 plasmid pShin-11, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccgtcgatggtgtcattgccag	Protospacer
************* * *********.*

23. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_021911 (Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1f, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
ctccgccgtcgagcgtgtcattgccgg	Protospacer
* ********** ** ***********

24. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_021911 (Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1f, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
ctccgccgtcgagcgtgtcattgccgg	Protospacer
* ********** ** ***********

25. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_006569 (Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgccaccgtcgatcgtgtcattgccgg	Protospacer
*.**.********** ***********

26. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_010997 (Rhizobium etli CIAT 652 plasmid pC, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
ctccgccgtcgagcgtgtcattgccgg	Protospacer
* ********** ** ***********

27. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_010997 (Rhizobium etli CIAT 652 plasmid pC, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
ctccgccgtcgagcgtgtcattgccgg	Protospacer
* ********** ** ***********

28. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_010997 (Rhizobium etli CIAT 652 plasmid pC, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
ctccgccgtcgagcgtgtcattgccgg	Protospacer
* ********** ** ***********

29. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_007949 (Polaromonas sp. JS666 plasmid 1, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgccgccgtcaagcgagtcattgccgg	Protospacer
*.********.* **************

30. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_007949 (Polaromonas sp. JS666 plasmid 1, complete sequence) position: , mismatch: 3, identity: 0.889

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgccgccgtcaagcgagtcattgccgg	Protospacer
*.********.* **************

31. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP021653 (Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.852

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
tgtcgccgtcgccgttgtcgtcttcgg	Protospacer
**********.***********.* *

32. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP012688 (Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.852

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
tgtcgccgtcgccgttgtcgtcttcgg	Protospacer
**********.***********.* *

33. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to CP047139 (Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.852

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
tgtcgccgtcgccgttgtcgtcttcgg	Protospacer
**********.***********.* *

34. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to CP047137 (Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.852

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
tgtcgccgtcgccgttgtcgtcttcgg	Protospacer
**********.***********.* *

35. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP007796 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence) position: , mismatch: 4, identity: 0.852

tgtcgccgtcaccgttgtcgtc-ctggc	CRISPR spacer
cgtcgccgtcaccgttgccgtcgctcg-	Protospacer
.****************.**** ** *

36. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP015747 (Shinella sp. HZN7 plasmid pShin-11, complete sequence) position: , mismatch: 4, identity: 0.852

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
gaccgccgtcgatcgtgtcgttgccgc	Protospacer
 ************** ***.******

37. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP015234 (Epibacterium mobile F1926 plasmid unnamed4, complete sequence) position: , mismatch: 4, identity: 0.852

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
agccaccttcgatcgagtcattgccgg	Protospacer
 .**.** *******************

38. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP015234 (Epibacterium mobile F1926 plasmid unnamed4, complete sequence) position: , mismatch: 4, identity: 0.852

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
agccaccttcgatcgagtcattgccgg	Protospacer
 .**.** *******************

39. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_021911 (Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1f, complete sequence) position: , mismatch: 4, identity: 0.852

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
ctccgccgtcgagcgtgtcattgcccg	Protospacer
* ********** ** ********* *

40. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP010732 (Phaeobacter inhibens strain P88 plasmid pP88_g, complete sequence) position: , mismatch: 4, identity: 0.852

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caccgccatcgatccagtcattgccat	Protospacer
*******.****** **********.

41. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP032687 (Rhizobium sp. CCGE531 plasmid pRCCGE531b, complete sequence) position: , mismatch: 4, identity: 0.852

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
gaccgccgtcgatccagtcatttcccg	Protospacer
 ************* ******* ** *

42. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP021045 (Phaeobacter gallaeciensis strain P129 plasmid pP129_e, complete sequence) position: , mismatch: 4, identity: 0.852

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgccgccatcgatccagtcattgccgt	Protospacer
*.*****.****** ***********

43. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP010685 (Phaeobacter piscinae strain P14 plasmid pP14_d, complete sequence) position: , mismatch: 4, identity: 0.852

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgccgccatcgatccagtcattgccgt	Protospacer
*.*****.****** ***********

44. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP032696 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525b, complete sequence) position: , mismatch: 4, identity: 0.852

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
aaccgccgtcgatccagtcatttcctg	Protospacer
 ************* ******* ** *

45. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP024313 (Rhizobium sp. NXC24 plasmid pRspNXC24b, complete sequence) position: , mismatch: 4, identity: 0.852

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
gaccgccgtcgatccagtcatttcccg	Protospacer
 ************* ******* ** *

46. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP034347 (Roseovarius sp. MME-070 plasmid pMME07001, complete sequence) position: , mismatch: 4, identity: 0.852

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgccgccgccgatcgtgtcattgcctg	Protospacer
*.******.****** ********* *

47. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP049248 (Rhizobium rhizoryzae strain DSM 29514 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.852

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
caaggccgtcgatcacgtcattgccgg	Protospacer
**  **********. ***********

48. spacer 5.1|1901043|26|NZ_CP011340|CRT matches to NZ_CP034156 (Rhodococcus sp. NJ-530 plasmid unnamed4, complete sequence) position: , mismatch: 5, identity: 0.808

aaaagccgcacacgaacggcgtcgcc	CRISPR spacer
cgaagccgaacacgaccggcgtcgca	Protospacer
 .****** ****** *********

49. spacer 5.2|1901091|31|NZ_CP011340|CRT matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 5, identity: 0.839

gaccg--ccgcacccggacccgtccgggcggca	CRISPR spacer
--ccgtcccgcacccggacccgcccgggcgggc	Protospacer
  ***  ***************.********

50. spacer 5.3|1901144|27|NZ_CP011340|CRT matches to MN329675 (Microbacterium phage SansAfet, complete genome) position: , mismatch: 5, identity: 0.815

acgcgccgcgccccaagggcctcacgc	CRISPR spacer
tcgagccgcgcgccaagggcctcaaga	Protospacer
 ** ******* ************ *

51. spacer 5.3|1901144|27|NZ_CP011340|CRT matches to NC_018022 (Mycolicibacterium chubuense NBB4 plasmid pMYCCH.01, complete sequence) position: , mismatch: 5, identity: 0.815

acgcgccgcgccccaagggcctcacgc	CRISPR spacer
ccgcgccgcggcccgagggcctcagcc	Protospacer
 ********* ***.*********  *

52. spacer 14.1|5128905|29|NZ_CP011340|CRISPRCasFinder matches to NC_011758 (Methylorubrum extorquens CM4 plasmid pCMU01, complete sequence) position: , mismatch: 5, identity: 0.828

gccacgaatccgggcgggcgccgcgaacc	CRISPR spacer
cgaacggatccgcgcgggcgccgcgaacc	Protospacer
   ***.***** ****************

53. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP040723 (Rhodococcus pyridinivorans strain YF3 plasmid unnamed4, complete sequence) position: , mismatch: 5, identity: 0.815

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
ccacgccgtcaccgtcgtagtcctggc	Protospacer
.  ************.** ********

54. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP016820 (Rhodococcus sp. p52 plasmid pDF02, complete sequence) position: , mismatch: 5, identity: 0.815

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
ccacgccgtcaccgtcgtagtcctggc	Protospacer
.  ************.** ********

55. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP016820 (Rhodococcus sp. p52 plasmid pDF02, complete sequence) position: , mismatch: 5, identity: 0.815

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
ccacgccgtcaccgtcgtagtcctggc	Protospacer
.  ************.** ********

56. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to NC_014309 (Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome) position: , mismatch: 5, identity: 0.815

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
cgtcgccgtcgccgttgtcgtcttcgg	Protospacer
.*********.***********.* *

57. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP027023 (Streptomyces sp. WAC00288 plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.815

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
cgtcgccgtcaccgtcgtcgtcgggga	Protospacer
.**************.******  **

58. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to NC_013857 (Azospirillum sp. B510 plasmid pAB510c, complete sequence) position: , mismatch: 5, identity: 0.815

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
gctggccgtcaccgttgtcgccgtggc	Protospacer
  * ****************.* ****

59. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP015234 (Epibacterium mobile F1926 plasmid unnamed4, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
agccaccttcgatcgagtcattgccag	Protospacer
 .**.** *****************.*

60. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_021909 (Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1e, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
gaccaccgtcgatccagtcattgccca	Protospacer
 ***.********* ********** .

61. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_021909 (Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1e, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
gaccaccgtcgatccagtcattgccca	Protospacer
 ***.********* ********** .

62. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP021031 (Rhizobium sp. NXC14 plasmid pRspNXC14a, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgcgaccgtcgatccagtcattgccgc	Protospacer
*.* .********* ***********

63. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP020910 (Rhizobium etli strain NXC12 plasmid pRetNXC12d, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgcgaccgtcgatccagtcattgccgc	Protospacer
*.* .********* ***********

64. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP018229 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
tgccgccgtcgagcgtgtcattgccag	Protospacer
..********** ** *********.*

65. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_HG938354 (Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgccgccgttgatcgcgtcattgccct	Protospacer
*.*******.***** *********

66. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_HG938354 (Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgccgccgttgatcgcgtcattgccct	Protospacer
*.*******.***** *********

67. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_011368 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
ccgcgccgtcgatcgcgccattgccgc	Protospacer
*  ************ *.********

68. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP025431 (Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cggcgccgtcgagcgtgtcattgccgt	Protospacer
*. ********* ** **********

69. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP025431 (Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgtcgccgtcgatcacgtcattgccgc	Protospacer
*..***********. **********

70. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP021830 (Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgccgccgtcgatggcgtcattgcctc	Protospacer
*.*********** * *********

71. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP023072 (Sinorhizobium fredii CCBAU 83666 plasmid pSF83666a, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
ctcgaccgtcgatccagtcattgccgt	Protospacer
* * .********* ***********

72. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP014598 (Yangia sp. CCB-MM3 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cggcgccgtccatcgagtcgttgccgt	Protospacer
*. ******* ********.******

73. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP017104 (Rhizobium gallicum strain IE4872 plasmid pRgalIE4872c, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgcgaccgtcgatccagtcattgccgc	Protospacer
*.* .********* ***********

74. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to CP006879 (Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602b, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
cgcgaccgtcgatccagtcattgccgc	Protospacer
*.* .********* ***********

75. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP041045 (Paracoccus sp. AK26 plasmid pAK1, complete sequence) position: , mismatch: 5, identity: 0.815

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
ccgtgccgtcgatcgcggcattgccgg	Protospacer
*  .*********** * *********

76. spacer 5.2|1901091|31|NZ_CP011340|CRT matches to NZ_CP040720 (Rhodococcus pyridinivorans strain YF3 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.806

----gaccgccgcacccggacccgtccgggcggca	CRISPR spacer
acgacaccg----acccggacccggccgggcggca	Protospacer
     ****    *********** **********

77. spacer 5.2|1901091|31|NZ_CP011340|CRT matches to NZ_CP016821 (Rhodococcus sp. p52 plasmid pDF01, complete sequence) position: , mismatch: 6, identity: 0.806

----gaccgccgcacccggacccgtccgggcggca	CRISPR spacer
acgacaccg----acccggacccggccgggcggca	Protospacer
     ****    *********** **********

78. spacer 5.3|1901144|27|NZ_CP011340|CRT matches to NZ_CP044217 (Mesorhizobium sp. NIBRBAC000500504 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.778

acgcgccgcgccccaagggcctcacgc	CRISPR spacer
cgaagctgcgccccaagggcctcaagc	Protospacer
  . **.***************** **

79. spacer 14.1|5128905|29|NZ_CP011340|CRISPRCasFinder matches to KT221034 (Streptomyces phage SF3, complete genome) position: , mismatch: 6, identity: 0.793

gccacgaatccgggcgggcgccgcgaacc	CRISPR spacer
ccgaccagtccgggcgggcgccgcgagct	Protospacer
 * ** *.******************.*.

80. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 6, identity: 0.778

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
tgtcgccgtcaccgttggcgaccatca	Protospacer
***************** ** **

81. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to MH727561 (Mycobacterium phage Serendipitous, complete genome) position: , mismatch: 6, identity: 0.778

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
acacgccgtcaccgtcgtcgtccttgg	Protospacer
   ************.******** *

82. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to MF417927 (Uncultured Caudovirales phage clone 9F_2, partial genome) position: , mismatch: 6, identity: 0.778

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
catcgcggtcgccgttgtcgtcctgct	Protospacer
..**** ***.************** .

83. spacer 18.4|6162935|30|NZ_CP011340|CRISPRCasFinder matches to MN856022 (Bacteriophage sp. isolate 138, complete genome) position: , mismatch: 6, identity: 0.8

ggccgtcgttctgcccgccgttctggtcac	CRISPR spacer
gaccgtcgctctgcccgcggttctgacaac	Protospacer
*.******.********* ******.. **

84. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP025013 (Rhizobium leguminosarum strain Norway plasmid pRLN1, complete sequence) position: , mismatch: 6, identity: 0.778

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
tctcgccgtcgatcgagtcatcggcga	Protospacer
. .******************.* **.

85. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NC_021240 (Paracoccus marcusii strain DSM 11574 plasmid pMARC3, complete sequence) position: , mismatch: 6, identity: 0.778

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
ttccgccgtcgatggagtcatttccta	Protospacer
. *********** ******** ** .

86. spacer 20.4|7402879|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 6, identity: 0.778

caccgccgtcgatcgagtcattgccgg	CRISPR spacer
agtcggcgttgatcgagtcattgccgc	Protospacer
 ..** ***.****************

87. spacer 5.2|1901091|31|NZ_CP011340|CRT matches to NZ_CP033584 (Streptomyces sp. ADI95-16 plasmid pADI95-16c, complete sequence) position: , mismatch: 7, identity: 0.774

gaccg--ccgcacccggacccgtccgggcggca	CRISPR spacer
--ccagtccgaacccggacccgtcggggcgggg	Protospacer
  **.  *** ************* ****** .

88. spacer 5.2|1901091|31|NZ_CP011340|CRT matches to NZ_CP012477 (Arthrobacter sp. ERGS1:01 isolate water plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.774

gaccgccgcacccggacccgtccgggcggca	CRISPR spacer
gacggccgcacccggacccgtcgccaccgcc	Protospacer
*** ******************   .* **

89. spacer 5.2|1901091|31|NZ_CP011340|CRT matches to NZ_CP032325 (Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence) position: , mismatch: 7, identity: 0.774

gaccgccgcacccggacccgtccgggcggca	CRISPR spacer
gttcgccgcacccggaccggtgcgggtgacc	Protospacer
* .*************** ** ****.*.*

90. spacer 9.2|3409702|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP029179 (Acidibrevibacterium fodinaquatile strain G45-3 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.741

gagttcccgtccccgccggcaaggtca	CRISPR spacer
agcgcgccgtccccgccggcaagatca	Protospacer
..  . *****************.***

91. spacer 9.2|3409702|27|NZ_CP011340|CRISPRCasFinder matches to NZ_CP034352 (Streptomyces sp. W1SF4 plasmid p2, complete sequence) position: , mismatch: 7, identity: 0.741

gagttcccgtccccgccggcaaggtca	CRISPR spacer
accagcccgtccccgccggccaggtcg	Protospacer
.    *************** *****.

92. spacer 14.1|5128905|29|NZ_CP011340|CRISPRCasFinder matches to NZ_CP029830 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.759

gccacgaatccgggcgggcgccgcgaacc	CRISPR spacer
ccgccgaatccgggcggccgccgcgcgtc	Protospacer
 *  ************* ******* ..*

93. spacer 18.2|6162845|27|NZ_CP011340|CRISPRCasFinder matches to MN908685 (Microbacterium phage PauloDiaboli, complete genome) position: , mismatch: 7, identity: 0.741

tgtcgccgtcaccgttgtcgtcctggc	CRISPR spacer
ggtcgccgtcaccgttgtcgatgatgt	Protospacer
 ******************* .   *.

94. spacer 18.4|6162935|30|NZ_CP011340|CRISPRCasFinder matches to NZ_CP025013 (Rhizobium leguminosarum strain Norway plasmid pRLN1, complete sequence) position: , mismatch: 7, identity: 0.767

ggccgtcgttctgcccgccgttctggtcac	CRISPR spacer
cgccgccggtctgcccgccgttctcgacca	Protospacer
 ****.** *************** * *

95. spacer 18.4|6162935|30|NZ_CP011340|CRISPRCasFinder matches to NZ_CP048281 (Rhizobium leguminosarum bv. viciae 248 plasmid pRle248e, complete sequence) position: , mismatch: 7, identity: 0.767

ggccgtcgttctgcccgccgttctggtcac	CRISPR spacer
cgccgccggtctgcccgccgttctcgacca	Protospacer
 ****.** *************** * *

96. spacer 5.2|1901091|31|NZ_CP011340|CRT matches to NC_015724 (Cupriavidus necator N-1 plasmid pBB2, complete sequence) position: , mismatch: 8, identity: 0.742

gaccgccgcacccggacccgtccgggcggca	CRISPR spacer
tctcgccgcacccggacccggccgtgccggt	Protospacer
  .***************** *** ** *

97. spacer 5.2|1901091|31|NZ_CP011340|CRT matches to NZ_CP045095 (Streptomyces sp. GY16 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.742

gaccgccgcacccggacccgtccgggcggca	CRISPR spacer
cgcggtaccaccaggacccgtccgggcggcg	Protospacer
 .* *.  **** *****************.

98. spacer 5.2|1901091|31|NZ_CP011340|CRT matches to LN997843 (Streptomyces reticuli genome assembly TUE45, plasmid : II) position: , mismatch: 8, identity: 0.742

gaccgccgcacccggacccgtccgggcggca	CRISPR spacer
gcccgccgcacccgcacccggccggccccgc	Protospacer
* ************ ***** **** *

99. spacer 5.2|1901091|31|NZ_CP011340|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 8, identity: 0.742

gaccgccgcacccggacccgtccgggcggca	CRISPR spacer
cgccgccgcacccggacccgtgcaggagctg	Protospacer
 .******************* *.** * ..

100. spacer 5.2|1901091|31|NZ_CP011340|CRT matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.742

gaccgccgcacccggacccgtccgggcggca	CRISPR spacer
gcctgccgcaccccgtcccgtccgggccagg	Protospacer
* *.********* * *********** . .

101. spacer 5.2|1901091|31|NZ_CP011340|CRT matches to MK112530 (Mycobacterium phage BigPaolini, complete genome) position: , mismatch: 8, identity: 0.742

gaccgccgcacccggacccgtccgggcggca	CRISPR spacer
tggtgcgtcacccggacaggtccgggcggca	Protospacer
 . .**  *********  ************

102. spacer 18.4|6162935|30|NZ_CP011340|CRISPRCasFinder matches to MN204493 (Streptomyces phage Zuko, complete genome) position: , mismatch: 8, identity: 0.733

ggccgtcgttctgcccgccgttctggtcac	CRISPR spacer
cctggtcgttctgcccggcgtcctggtcgt	Protospacer
  . ************* ***.******..

103. spacer 18.4|6162935|30|NZ_CP011340|CRISPRCasFinder matches to NZ_CP029209 (Nitratireductor sp. OM-1 plasmid pOM-1, complete sequence) position: , mismatch: 8, identity: 0.733

ggccgtcgttctgcccgccgttctggtcac	CRISPR spacer
tgccgccattctgcccgccgttctctacta	Protospacer
 ****.*.****************   *

104. spacer 13.1|4616399|38|NZ_CP011340|CRISPRCasFinder matches to NZ_CP029452 (Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence) position: , mismatch: 10, identity: 0.737

cgggagtggcgtccgcccgcggagaagggggcggcgcc	CRISPR spacer
cagacgcccgctccgcccgcggagcaggaggcggcgcc	Protospacer
*.*. *.    ************* ***.*********

105. spacer 13.1|4616399|38|NZ_CP011340|CRISPRCasFinder matches to NZ_CP023071 (Sinorhizobium fredii CCBAU 83666 plasmid pSF83666b, complete sequence) position: , mismatch: 10, identity: 0.737

cgggagtggcgtccgcccgcggagaagggggcggcgcc	CRISPR spacer
cagacgcccgctccgcccgcggagcaggaggcggcgcc	Protospacer
*.*. *.    ************* ***.*********

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP011340

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection