CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP012649	Trueperella pyogenes strain 2012CQ-ZSH, complete genome	1 crisprs	cas3,DEDDh,csa3,cas4,WYL,DinG	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012649_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012649_1

1467618-1467715

Orphan

Consensus_repeat	Method
GGCCATGTACACCATGCACACTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012649_1

>merge|NZ_CP012649|1|1467618-1467715|CRISPRCasFinder
GGCCATGTACACCATGCACACTACTAGGTTTTCTTGGTGTACACGGGTTTAGCCTCGTGTACCAGGCAAATCGAGGCCAATGTACACCATGCACACTA

>NZ_CP012649|1|1|1467618-1467715|CRISPRCasFinder
GGCCATGTACACCATGCACACTA	CTAGGTTTTCTTGGTGTACACGGGTTTAGCCTCGTGTACCAGGCAAATCGAG
GCCAATGTACACCATGCACACTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012649.1\|WP_053793706.1\|1457316_1457763_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012649.1\|WP_024964002.1\|1462100_1462634_+\|SsrA-binding-protein-SmpB	unknown	unknown	gnl\|CDD\|376590
NZ_CP012649.1\|WP_053793714.1\|1471912_1472482_+\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_CP012649.1\|WP_024964006.1\|1457772_1458903_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NZ_CP012649.1\|WP_080999119.1\|1475559_1476777_+\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP012649.1\|WP_053793713.1\|1470832_1471906_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366631
NZ_CP012649.1\|WP_053793717.1\|1473299_1474529_-\|relaxase/mobilization-nuclease-domain-containing-protein	unknown	unknown	gnl\|CDD\|367497
NZ_CP012649.1\|WP_053793712.1\|1469006_1470836_+\|N-6-DNA-methylase	unknown	unknown	gnl\|CDD\|280533
NZ_CP012649.1\|WP_155467677.1\|1472749_1473382_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012649.1\|WP_024964005.1\|1459056_1459749_+\|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl\|CDD\|225438
NZ_CP012649.1\|WP_053793715.1\|1472527_1472734_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012649.1\|WP_155467679.1\|1475195_1475570_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012649.1\|WP_053793710.1\|1465725_1467321_-\|recombinase	unknown	unknown	gnl\|CDD\|214861
NZ_CP012649.1\|WP_024964001.1\|1462730_1463495_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP012649.1\|WP_053794049.1\|1474525_1474846_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368576
NZ_CP012649.1\|WP_053793707.1\|1459745_1460654_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225088
NZ_CP012649.1\|WP_053793711.1\|1468251_1468782_+\|antirestriction-protein-ArdA	unknown	unknown	gnl\|CDD\|377800
NZ_CP012649.1\|WP_038567834.1\|1460674_1461994_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|223810
NZ_CP012649.1\|WP_053793709.1\|1464669_1465236_+\|adenylate-kinase	unknown	unknown	gnl\|CDD\|181235
NZ_CP012649.1\|WP_053793708.1\|1463487_1464585_-\|LD-carboxypeptidase	unknown	unknown	gnl\|CDD\|132883

Protein	Function_ID	Function_description	E-value
NZ_CP012649.1\|WP_024964002.1\|1462100_1462634_+\|SsrA-binding-protein-SmpB	gnl\|CDD\|376590	pfam01668, SmpB, SmpB protein.	4.02477e-75
NZ_CP012649.1\|WP_053793714.1\|1471912_1472482_+\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	3.65956e-49
NZ_CP012649.1\|WP_024964006.1\|1457772_1458903_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NZ_CP012649.1\|WP_080999119.1\|1475559_1476777_+\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	7.26681e-16
NZ_CP012649.1\|WP_053793713.1\|1470832_1471906_+\|hypothetical-protein	gnl\|CDD\|366631	pfam01420, Methylase_S, Type I restriction modification DNA specificity domain. This domain is also known as the target recognition domain (TRD). Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity subunit (this family), two modification (M) subunits and two restriction (R) subunits.	3.46078e-14
NZ_CP012649.1\|WP_053793717.1\|1473299_1474529_-\|relaxase/mobilization-nuclease-domain-containing-protein	gnl\|CDD\|367497	pfam03432, Relaxase, Relaxase/Mobilisation nuclease domain. Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation. The relaxase, in conjunction with several auxiliary proteins, forms the relaxation complex or relaxosome. Relaxases nick duplex DNA in a specific manner by catalyzing trans-esterification.	5.12227e-14
NZ_CP012649.1\|WP_053793712.1\|1469006_1470836_+\|N-6-DNA-methylase	gnl\|CDD\|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	1.18511e-20
NZ_CP012649.1\|WP_024964005.1\|1459056_1459749_+\|cell-division-ATP-binding-protein-FtsE	gnl\|CDD\|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	2.54336e-112
NZ_CP012649.1\|WP_053793710.1\|1465725_1467321_-\|recombinase	gnl\|CDD\|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	2.15838e-32
NZ_CP012649.1\|WP_024964001.1\|1462730_1463495_+\|HAD-family-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.02989e-118
NZ_CP012649.1\|WP_053794049.1\|1474525_1474846_-\|hypothetical-protein	gnl\|CDD\|368576	pfam05713, MobC, Bacterial mobilisation protein (MobC). This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis-active site of a mobilising plasmid, the origin of transfer (oriT) region. The absence of MobC has several different effects on oriT DNA. Site- and strand-specific nicking by MobA protein is severely reduced, accounting for the lower frequency of mobilisation. The localized DNA strand separation required for this nicking is less affected, but becomes more sensitive to the level of active DNA gyrase in the cell. In addition, strand separation is not efficiently extended through the region containing the nick site. These effects suggest a model in which MobC acts as a molecular wedge for the relaxosome-induced melting of oriT DNA. The effect of MobC on strand separation may be partially complemented by the helical distortion induced by supercoiling. However, MobC extends the melted region through the nick site, thus providing the single-stranded substrate required for cleavage by MobA.	0.00339411
NZ_CP012649.1\|WP_053793707.1\|1459745_1460654_+\|ABC-transporter-permease	gnl\|CDD\|225088	COG2177, FtsX, Cell division protein [Cell division and chromosome partitioning].	4.70973e-43
NZ_CP012649.1\|WP_053793711.1\|1468251_1468782_+\|antirestriction-protein-ArdA	gnl\|CDD\|377800	pfam07275, ArdA, Antirestriction protein (ArdA). This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.	2.88313e-20
NZ_CP012649.1\|WP_038567834.1\|1460674_1461994_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|223810	COG0739, NlpD, Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane].	1.59081e-35
NZ_CP012649.1\|WP_053793709.1\|1464669_1465236_+\|adenylate-kinase	gnl\|CDD\|181235	PRK08118, PRK08118, DNA topology modulation protein.	5.66955e-11
NZ_CP012649.1\|WP_053793708.1\|1463487_1464585_-\|LD-carboxypeptidase	gnl\|CDD\|132883	cd07062, Peptidase_S66_mccF_like, Microcin C7 self-immunity protein determines resistance to exogenous microcin C7. Microcin C7 self-immunity protein (mccF): MccF, a homolog of the LD-carboxypeptidase family, mediates resistance against exogenously added microcin C7 (MccC7), a ribosomally-encoded peptide antibiotic that contains a phosphoramidate linkage to adenosine monophosphate at its C-terminus. The plasmid-encoded mccF gene is transcribed in the opposite direction to the other five genes (mccA-E) and is required for the full expression of immunity but not for production. The catalytic triad residues (Ser, His, Glu) of LD-carboxypeptidase are also conserved in MccF, strongly suggesting that MccF shares the hydrolytic activity with LD-carboxypeptidases. Substrates of MccF have not been deduced, but could likely be microcin C7 precursors. The possible role of MccF is to defend producer cells against exogenous microcin from re-entering after having been exported. It is suggested that MccF is involved in microcin degradation or sequestration in the periplasm.	2.76189e-85

>NZ_CP012649.1|WP_053793710.1|1465725_1467321_-|recombinase
MKVYPPFNENSMVVAYYRYSSSSQNEASIEQQREMVQRWASAQGFFVVSEYEDAARTGTTADRPGYQLMLRDLPKIKPAYVAVWKNDRLARDRAELLLVKQAIRSVGARLHYIEGISPNDSPDSVLMEGVADAFAEYYSRQLSANIRRGQRYNAERALSNGQKVFGYVRSADKRYIPDPETAPLVTQIFSDYASGISMQKIADRLNAQGVRTVRGAKFSTKTLNKMLKNRAYLGVYAYGEYVHEDGMPRLVDDETFDKVQRRFSINKRLGAKTKAELSAQGEEAPDYWLTGRMYCRKCGAPMEGVSGTSKTGRKYRYYYCLNQRKKKCDAKPVRKDEIELQVEDIIASFLDDPEMLASLAVDMADHYRKTHGQGNEVLKALEARRKDVEMKLGNFAKAIAQGIFNETTAAAMRSLEEQKHELDDAIQTENVRTALFEDEASIGAFYKRFAKATLDTVETRDQLFEYFVDKIYLSKEQVIVVTYYFDSVKTFEVDDLDEALKNLHENGELRTFSRTSRREFNSSPFSGDGEN
>NZ_CP012649.1|WP_053793709.1|1464669_1465236_+|adenylate-kinase
MPRAIFDDVARARRILFYGVTGSGKSTAATRFGQARGLPVVLVDDAVGWLPADVAPWTNRDDEAMRAIAADLAAEEEWVFDSAYSQFRDVVYGRAQLMIALDYPRWLSLGRLVRRTWRRVVDGDEVCNGNRENWKQVFSRDSILRWHFHSFASKRDRIRELEASLTGVPVLRLTHPSQLEELIAFVRR
>NZ_CP012649.1|WP_053793708.1|1463487_1464585_-|LD-carboxypeptidase
MTNKMLAPKTINPGDKVALLSPAWAAPAYFPQIHVQAVERLERLLDVEVVEYPTTRKMNASVTERAADVNAAFADPEIRAILTTVGGDDLIRVVPHLDPALPQADPKPFFGYSDNTNILNWLWANGVSAYHGGATQVHFGPGSLVDAEHLFTFRAALFGQGDTVIPIPEDSQDFGFDWSSPKALTEDSPRGPALPVEFLGSDDAVTGLTWGGCMEVLDQLAMADRLPSAAELEGAILLFETSELIPPADTVGRWIRAFGERGYLEAAAGLVFARPVVDDRDAPAPPPVLQSRRDAYTEYVLSNLSLYRQDMPVCLNLPFGHTRPQVVLPYGGHITIDPVAEQVIAHFPGLATSPGTLPAEDGVVK
>NZ_CP012649.1|WP_024964001.1|1462730_1463495_+|HAD-family-hydrolase
MTSAWLIDMDGVLVHEGMALDGAKEFLERLDEHGIPHLILTNNSIFTTRDLSARLATSGLNVPPERIWTSALATAKFLAGQTENRRAFVVGEAGLTTALYEEGFVMTSAEPDFVVLGETRTYSFELLTKAIRLIQDGARFIATNPDPTGPSADGDIPATGAVAAMIEKATGRQPFFVGKPNPVMLRNGLNKIGAHSEETSIVGDRMDTDIQAGVETGLTTHLVLTGSTKRKDIVRYPYRPDHVHESIRDVIEFI
>NZ_CP012649.1|WP_024964002.1|1462100_1462634_+|SsrA-binding-protein-SmpB
MPKAWKKNNAKLTPAQKAKEAADAKQVVARNKKARHDYFIDKTYEAGLVLAGTEVKALRAGRASLMEAWIDFDRRGEAWLVGANIPVWSTGGWTNHAPTQKRKLLLHKDELRTLAVKVKEKGTTVVPLELYFIRGRAKVEIGLARGKQEWDKRETLRRKQDQREAERAVAEARKRAR
>NZ_CP012649.1|WP_038567834.1|1460674_1461994_+|peptidoglycan-DD-metalloendopeptidase-family-protein
MSAIAAMVLAAGVLAAPALADERSDLVDKQHEQKAEKERLQSELEGIDVNLQEAYLHLEETRGKIPEAEAAVQSAEVELAASVRELEANTALLQAAQGELRGIKTEIEENEASADATRKTLGELARATYRGDTMPSALDMLVGSATAEDFTNAYRAQSAVSRSQAASLVQFQQRAAQSKNRQARQSAVEEQIEDLKAKSEELVGAQKAKKAEADSRKAELLSLESSLVTQSKDFEERKSNYQSSLKNLETQSEQTAKRIAEIDEENRRKEAAERAARKAAERARRQPNAPAAPAAPGGSWIQPPVPAPVYVTSPFGMRVYPFGGRWMHNGVDLRSRCGEPQTAPADGVVSAVVPAAGNGTHGNQIFINHGMVGGSSYVTVTNHLSAFNVKPGQSVKQGQVIGWTGQTGLVTACHVHFEVWQNGRVIDPMSLPSFTRRYS
>NZ_CP012649.1|WP_053793707.1|1459745_1460654_+|ABC-transporter-permease
MRLRFIFSQVFKGLRTNFALSASVTLVAFVSLLFVGAAVLLQNQIESAKNAWYDRVEVSAFLCAPDQNTAQCAGGEATQEQIDALDKFLHSPQMAGYVEKVFFETKEEAYKNFREYLKDSAWVDTVSPQQMQASFRVKLVNPEEYDVVRESIEGRPGVDTVIDQREQLEPLFKMLNRFTLIAGVLASVMIITALLLIPATIRLSAMFRKNETEIMRFVGASNSFIHAPFILEGMLAALVGSLAAAATLWITVEYFIQDWFAGSWLRIITGHDVLVLMPWLIVGALIVAGFASFLALRRYTRV
>NZ_CP012649.1|WP_024964005.1|1459056_1459749_+|cell-division-ATP-binding-protein-FtsE
MITFDNVTKVYQRGAAPALDDVSLNIDRGEFVFLVGASGSGKSTMLALILAEERPTQGRVHVLGKDLASVSSRRVPFLRRQIGTVFQDFRLLEDKNVFDNVALAMQVTGRPRHAILKEVPQVLELVGLDGKEKRRMHELSGGEKQRVAIARAMVNRPELLLADEPTGNLDHKTALGIMRLLDRINRQGTTVVMATHDQAIVNQLRKRVIELVAGNVVRDQDRGVYGGSQA
>NZ_CP012649.1|WP_024964006.1|1457772_1458903_+|peptide-chain-release-factor-2
MAIDYQQELDKLRRTFDQIEAVSDVPALKASIADLTEKSAAPDLWDDPDAAQAVTSKLSHAQSKLERIEKMGERVEDAETLYEMAVEESTSDVASGQELYAELDSEITKISADLSDLEIKTLLSGEYDERDAVVTIRSGAGGVDAADFAQMLQRMYLRWAERHGYKTKVMDTSYAEEAGIKSTTFEVSAPYAYGTLSVEAGTHRLVRISPFDNQGRRQTSFAAVEVIPLIETTDSIEIPDTELKIDVFRSSGPGGQSVNTTDSAVRMTHIPTGITVSMQDEKSQIQNRAAALRVLQSKLLQKRHEEEQAKKRELAGDVKASWGDQMRSYVLHPYQMVKDLRTGHEVGNTDAVFDGDLDGFIDAGIRWRQSDKNSEG
>NZ_CP012649.1|WP_053793706.1|1457316_1457763_+|hypothetical-protein
MTAQADRRYAGAAGRCTGAEEGNLIVLGLGVWVVVISLIVILASVIHIHGVRRDMLNTADALALELAQDLADSAYYSSSALNLIPEPPASGTITVDGREVRFRTEVANDAVVVTLVGKVQIVFFPRFLDAMDEVELTVTSTAALRQMP
>NZ_CP012649.1|WP_053793711.1|1468251_1468782_+|antirestriction-protein-ArdA
MTTQSTTVRPAVWIGCLACYNEGVLNGEWFAAEDAEKVTLLTLHRNPTDHEEIWAFDIEGFPRGTSEMSAHTAALWGELFHEVGETLWEPLLAWVENGSYVEDSNGLPDFSSFEDRYRGCWPSFADYLADEIEALQQGWPEEAIRYFDEKAYERDAQFDYDILDAPGGEIFIFASF
>NZ_CP012649.1|WP_053793712.1|1469006_1470836_+|N-6-DNA-methylase
MSPHPMTEDEVRENAGVALGFSEVDSSVARAGVGQITTLKQLGFIGEGASLKPDGWYLPVDRGLPAFVLETKAPGVMSIDAPALKAQVEKYCDVIRSRYDIVIGIVYDGEQVRAYLNSQPFEVPNELQTVKYYTDRLLDQPIDKERIYELTMRINNSLHGDFGIKNLYHRMIFTACALVARRYDAVLVRGMDYPDFHNGILSALNKAIRSDKEQNSKLQLLADVYSEIKMNVSTDDDDPRAVQRLTNLIGDFIDWITEISGLINSSRWDGEDVMAIFFNEFNRYKKKSESGQVFTPDHVTGFMYRLLGVNMNDRVLDACAGSGSFLVKAMSNMIREAGGVGTRKAKQIKREQLYGIEFDREIYALACANMLIHKDGKTNLAHMDARTDSASEWMQSTRATKVLMNPPYENKFGCMTIVENVLNSVDRGILCGFILPDKKLEKTPKVQMSRILRHHRLLKVVKMPENLFFGIGVTTSIFIFQTGVPQDGKEFFAVNIAEDGLVTVKNKGRHDVYNKWPELEDYWVDAIAKQNDTRFGTGQWHSPDECLSWQAPVKPFELTEEDLARTAMDYVMFQQGIDAAETRERLGAIATYAADITEDDQRFRMEVEK
>NZ_CP012649.1|WP_053793713.1|1470832_1471906_+|hypothetical-protein
MTTIDTSTWGEFVVTDLFEHIERGKGSGAGSFMNGAVPYIAASFANNGYVRGVADADGSLTSDGNCIAMIVNGNGGIGRNTYQADPFVGSSDLQLGYHPRLNVYTGLFLVACLNKSIERYGYNFQWKRTGNAFAQETVFLPVTIDGQPDWNYMQSVMERQIAEQEERLNSLLGISSSPVRKVDSSNWANFQIQDLFTIERAKRRTINSYAKGGVPYVTNSAFNNGVTDYLQPKSKDDIEKGRCITINTVDGSVFWQPHDFLANSSGNGLIILRRENLEETAALFLCSIIEAHLDPTFQMMLTTDDIRNLTLPLPATVDGAPDWVFMTTKMEKELLAAEAKIAMLHRVMTDVRIEEEG
>NZ_CP012649.1|WP_053793714.1|1471912_1472482_+|recombinase-family-protein
MKIGYARVSTARQGQSLDTQREALVDAGCDAQHLYSDTISGTKWSRPGLTNALDYMRPGDTLVVTRLDRLGRNLYETVTTIADLAERDINVQVLDPSLDTSRPADKVVVNVMASLAEWERELLVERTREGVAHARAQGRVAGPKPKLTDEQARQARQLVDGGESVSAVARSFGVSRQTLYRALERETVS
>NZ_CP012649.1|WP_053793715.1|1472527_1472734_-|hypothetical-protein
MDLKPIIGPNLKISKPRVKNTRADRERQAERLDGSVRKGESVSEYQSRMIRQINSLDWSSKVDDELEL
>NZ_CP012649.1|WP_155467677.1|1472749_1473382_-|hypothetical-protein
MKKSDLESYIMMTNLKETMETTTSSLVELKKVVGNGRTVRVDVEALGKYTVGVLDQRLAKAVEAPVQRIEATLDEFEQRVAEIGSQRVSETTKQVDKTLDKADELIKEIGHAEKRLEALERRVTWTSVSRLCVALLPLAAVLLVVGGLTMGVFHALGFGPLLGWAWGSFAAASTWWAKALIALGTLGGIALFSSVIWWAAKKINDELRTW
>NZ_CP012649.1|WP_053793717.1|1473299_1474529_-|relaxase/mobilization-nuclease-domain-containing-protein
MSTVNVQPTTSARSAVSYALYGTGKRRDEHAKEDTTRAALMSCTLESPEAIVMRAEQVSSAFNRRNEMYTYTQNFSPEEFDVNNPEHVKRVHELGVKLAKRMNSADHLVVTHTDSAGGHLHNHIYVINHDNLTGKALSRCRSWSRGLRQINDELMRDEGCQVLPDPQQPKPDWDVRREAFKEGGFEQLLGDKVMEALLDPRSVDREAFEQVLAEHEVRLRITDRDGWTYSMRRLDNGKWGRKKASALCDEFMNAKVEEVFAFHQQNNEKEKEDERVGQAQGAAASIGTISSLGAAPRRRGTERHHVGEELRPGEQVPQRDGQEPGGRDGGAGNVDLAAARQALTEAAEQRDRDQAERDREDAERRRRAADRENRRKAAERRAREEVRLGVLHHDDESQGDYGDDDFELG
>NZ_CP012649.1|WP_053794049.1|1474525_1474846_-|hypothetical-protein
MRLTPNELDAIKRRASVLGVKPSQWARAVLRDALDSRRHEVEVLAAQAGMTRPRPELAKAVEQVRRIGVNLNQVVRAGTAVDEDILRDVLDAVREVRALLGDEVSL
>NZ_CP012649.1|WP_155467679.1|1475195_1475570_-|hypothetical-protein
MEITHPIVLGWATFRPSFLGYFSTVTDKMSENTMKNLDQLIKDAKDKHAAHLKRLRQQAAKEEQQLYVRVAQLFEQHEHDRFAQYRARAAQLIEQERAERAARAKAAREAKLAEQSDESGDGCD
>NZ_CP012649.1|WP_080999119.1|1475559_1476777_+|IS21-family-transposase
MISMDDWAQIRILRNEGMSIRKIASTVGCAKKTVERALASNTPPSYKQRAPQKTAFDEFELDVRALIDDVPDLPATVLAQRVGWTGSMSWFRENVRRIRPEYMPKDPVDVLDHKAGQQIQCDLMFPDDGITNDMGVPAKFPVLVMVSSYSRFMAACVLPTKTTGDLVSGMWMLLHDRFQVVPQHLLWDHESGIGNKRLVDQVVGFSGTLGLKVRQAPPRDPETKGIVERHNEYLQTSFFPGRRFTDPIDAQAQLDSWIDNIANKRIHATLKQRPVDRWAADKEAMSALPPYAPQTGLRRQVRLPRNYYVSVDSNRYSVSPAAIGKIVTIFVELHRVVITDSAGVIVADHRRVWGKNVTVTDPDHQRLAKQMRQSLAAPKPRACDIAVEAADLSIYDKIAGWEQSA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

645359 : 656499

Enterobacteria_phage(50.0%)

transposase,protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080999170.1\|645359_646070_-\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_024963122.1\|646073_646595_-	peptidylprolyl isomerase	A0A2H4UTF4	Bodo_saltans_virus	1.4e-19	42.2
WP_052250962.1\|646805_647600_+	hypothetical protein	NA	NA	NA	NA
WP_080999171.1\|647685_648963_-	peptidoglycan bridge formation glycyltransferase FemA/FemB family protein	NA	NA	NA	NA
WP_053793405.1\|649079_650354_+	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_039661480.1\|650506_651250_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_053793406.1\|651475_651817_-	hypothetical protein	NA	NA	NA	NA
WP_155467627.1\|651844_653070_-\|transposase	IS3 family transposase	Q6H9S3	Enterobacteria_phage	9.7e-56	43.3
WP_053793409.1\|653068_653386_+\|transposase	transposase	NA	NA	NA	NA
WP_080999119.1\|653563_654781_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_052251142.1\|654777_655575_+	DNA replication protein	U5N3V8	Enterobacteria_phage	8.8e-50	46.0
WP_155467629.1\|655587_656499_+\|transposase	IS3 family transposase	A0A1P8CWQ3	Bacillus_phage	3.0e-25	30.0

DBSCAN-SWA_2

1333436 : 1347346

uncultured_virus(11.11%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_024963390.1\|1333436_1333733_+	co-chaperone GroES	A0A221S308	uncultured_virus	1.8e-19	47.9
WP_155467669.1\|1333959_1334415_+	hypothetical protein	NA	NA	NA	NA
WP_039662050.1\|1334553_1335045_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	1.0e-19	38.8
WP_039662051.1\|1335112_1335820_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3FGF0	Synechococcus_phage	2.1e-39	38.9
WP_053793666.1\|1335852_1337352_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	4.4e-58	35.3
WP_053793667.1\|1337348_1338392_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	7.0e-63	43.6
WP_053793668.1\|1338388_1338967_+	phosphoribosylglycinamide formyltransferase	NA	NA	NA	NA
WP_053793669.1\|1338963_1340226_+	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
WP_053793670.1\|1340234_1343984_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	9.3e-33	25.1
WP_080753912.1\|1344077_1344323_+	hypothetical protein	NA	NA	NA	NA
WP_024963400.1\|1344473_1344770_-	WhiB family transcriptional regulator	A0A2P1CGA4	Mycobacterium_phage	7.9e-12	45.8
WP_024963401.1\|1344971_1346474_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	1.5e-95	41.0
WP_053793671.1\|1346623_1347346_-	DNA polymerase III subunit epsilon	Q1WDI5	Streptomyces_phage	1.2e-48	45.7

DBSCAN-SWA_3

2113460 : 2204272

Erysipelothrix_phage(39.02%)

holin,transposase,protease,portal,tail,capsid,terminase,tRNA,head

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_053793894.1\|2113460_2114816_-\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA
WP_039662652.1\|2114805_2115360_-	ribosome maturation factor RimM	NA	NA	NA	NA
WP_024963427.1\|2115440_2115677_-	RNA-binding protein	NA	NA	NA	NA
WP_024963426.1\|2115676_2116123_-	30S ribosomal protein S16	NA	NA	NA	NA
WP_053793895.1\|2116430_2117369_+	cation transporter	NA	NA	NA	NA
WP_053793896.1\|2117343_2117889_-	menaquinone-dependent protoporphyrinogen IX dehydrogenase	NA	NA	NA	NA
WP_053793897.1\|2117939_2118998_-	amidohydrolase family protein	NA	NA	NA	NA
WP_053793898.1\|2119004_2120546_-	signal recognition particle protein	NA	NA	NA	NA
WP_114949831.1\|2120631_2121762_-	signal recognition particle-docking protein FtsY	D6PHS7	uncultured_phage	1.4e-11	31.1
WP_039662662.1\|2122000_2123605_-	cholesterol-dependent cytolysin pyolysin	NA	NA	NA	NA
WP_039662664.1\|2124224_2124587_-	hypothetical protein	NA	NA	NA	NA
WP_053793899.1\|2124673_2128249_-	chromosome segregation protein SMC	NA	NA	NA	NA
WP_053793900.1\|2128386_2128800_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	6.0e-26	44.8
WP_053793901.1\|2128872_2130363_-	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_053793902.1\|2130362_2133566_-\|tRNA	isoleucine--tRNA ligase	A0A2I2L3Y0	Orpheovirus	4.1e-154	32.8
WP_039662670.1\|2133884_2134157_-	hypothetical protein	NA	NA	NA	NA
WP_053793903.1\|2134167_2135259_-	hypothetical protein	NA	NA	NA	NA
WP_053793904.1\|2135367_2136171_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	1.9e-31	36.2
WP_155467719.1\|2136167_2136707_-	hypothetical protein	NA	NA	NA	NA
WP_053793906.1\|2136789_2139423_+\|tRNA	valine--tRNA ligase	A0A2K9KZB8	Tupanvirus	4.0e-163	37.6
WP_052251370.1\|2139576_2141358_+	long-chain fatty acid--CoA ligase	A0A1V0SBX8	Catovirus	5.2e-58	25.9
WP_024964059.1\|2141382_2141694_-	chorismate mutase	NA	NA	NA	NA
WP_039662682.1\|2141750_2143019_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	8.6e-132	58.3
WP_039662684.1\|2143174_2143858_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	9.9e-34	41.0
WP_024964056.1\|2143867_2144497_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	1.6e-46	54.2
WP_053793907.1\|2144710_2146240_-	trigger factor	NA	NA	NA	NA
WP_053793908.1\|2146406_2147357_-	aldo/keto reductase	NA	NA	NA	NA
WP_039662689.1\|2147447_2148338_-	haloacid dehalogenase	NA	NA	NA	NA
WP_053793909.1\|2148337_2150107_-	beta-hexosaminidase	NA	NA	NA	NA
WP_053793910.1\|2150140_2151562_-	sugar (glycoside-pentoside-Hexuronide) transporter	NA	NA	NA	NA
WP_053793911.1\|2151813_2153586_+	beta-glucuronidase	B9U1V4	Vaccinia_virus	3.2e-169	50.0
WP_039662696.1\|2153623_2154616_-	LacI family transcriptional regulator	NA	NA	NA	NA
WP_025295903.1\|2155394_2155694_-	type II toxin-antitoxin system RelB/DinJ family antitoxin	NA	NA	NA	NA
WP_053793912.1\|2155949_2157575_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L0W2	Tupanvirus	4.8e-26	24.0
WP_053793913.1\|2157822_2159376_-	recombinase family protein	Q6DMS5	Streptococcus_phage	1.3e-126	47.9
WP_080999253.1\|2159380_2160619_-	recombinase family protein	A0A2K5B2B2	Erysipelothrix_phage	1.6e-58	35.7
WP_053793914.1\|2160698_2160881_-	hypothetical protein	NA	NA	NA	NA
WP_080999254.1\|2160877_2161279_-	hypothetical protein	A0A1B0RXC6	Streptococcus_phage	3.6e-15	34.5
WP_053793915.1\|2161479_2162418_-	hypothetical protein	A0A221J6T7	Arthrobacter_phage	2.5e-27	53.4
WP_080999255.1\|2162414_2162975_-\|holin	phage holin family protein	A0A2K5B2A2	Erysipelothrix_phage	4.2e-38	62.4
WP_053793916.1\|2162998_2163241_-	hypothetical protein	NA	NA	NA	NA
WP_053793917.1\|2163233_2163686_-	hypothetical protein	NA	NA	NA	NA
WP_053793918.1\|2163723_2166948_-	hypothetical protein	A0A1B1P770	Bacillus_phage	1.7e-46	37.6
WP_053793919.1\|2166944_2167637_-	hypothetical protein	NA	NA	NA	NA
WP_053793920.1\|2167645_2170294_-	tape measure protein	A0A2K9V3J7	Faecalibacterium_phage	8.9e-38	40.5
WP_053793921.1\|2170571_2170973_-	hypothetical protein	A0A2K5B295	Erysipelothrix_phage	1.8e-22	49.6
WP_053793922.1\|2170984_2171593_-\|tail	phage tail protein	A0A2K5B294	Erysipelothrix_phage	2.2e-69	66.0
WP_053793923.1\|2171611_2171962_-	hypothetical protein	A0A2K5B293	Erysipelothrix_phage	4.2e-20	40.9
WP_053793924.1\|2171958_2172381_-	hypothetical protein	A0A2K5B292	Erysipelothrix_phage	3.0e-20	43.0
WP_053793925.1\|2172505_2172883_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_053794061.1\|2172975_2173575_+	hypothetical protein	NA	NA	NA	NA
WP_080999285.1\|2173594_2173915_-\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_053793927.1\|2173935_2174253_-\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_053794062.1\|2174280_2175513_-\|capsid	phage major capsid protein	A0A2I4R671	Erysipelothrix_phage	1.1e-128	57.7
WP_053793928.1\|2175535_2176318_-\|protease	Clp protease ClpP	E4ZFM4	Streptococcus_phage	3.4e-54	58.8
WP_053793929.1\|2176314_2177610_-\|portal	phage portal protein	A0A2K5B287	Erysipelothrix_phage	2.1e-170	71.0
WP_053793930.1\|2177655_2178036_+	hypothetical protein	NA	NA	NA	NA
WP_053793931.1\|2178005_2179616_-\|terminase	terminase large subunit	A0A2K5B285	Erysipelothrix_phage	5.5e-232	74.3
WP_053793932.1\|2179687_2180002_-	hypothetical protein	NA	NA	NA	NA
WP_053793933.1\|2180195_2180579_-	hypothetical protein	NA	NA	NA	NA
WP_053793934.1\|2180783_2181083_-	hypothetical protein	NA	NA	NA	NA
WP_053793935.1\|2181210_2182071_-	DUF4314 domain-containing protein	A0A2K5B280	Erysipelothrix_phage	4.5e-23	34.9
WP_053793936.1\|2182172_2183408_-	DNA modification methylase	E4ZFL4	Streptococcus_phage	1.1e-131	57.6
WP_053793937.1\|2183379_2184564_-	methionine adenosyltransferase	A0A2K5B278	Erysipelothrix_phage	4.3e-101	53.4
WP_053793938.1\|2184659_2185235_-\|terminase	terminase	A0A2K5B277	Erysipelothrix_phage	3.4e-51	53.7
WP_080999286.1\|2185477_2185855_-	HNH endonuclease	A0A2K5B276	Erysipelothrix_phage	5.5e-34	54.6
WP_053793939.1\|2185973_2186189_+	hypothetical protein	NA	NA	NA	NA
WP_053793940.1\|2186334_2186793_-	hypothetical protein	NA	NA	NA	NA
WP_053793941.1\|2186795_2188154_-	DEAD/DEAH box helicase	A0A1L6BZE2	Pasteurella_phage	1.2e-155	62.2
WP_053794063.1\|2188134_2188413_-	VRR-NUC domain-containing protein	A0A2K5B272	Erysipelothrix_phage	1.2e-17	54.4
WP_053793942.1\|2188552_2190817_-	DNA primase	A0A1B0RXC5	Streptococcus_phage	1.1e-193	47.6
WP_053793943.1\|2190813_2191245_-	hypothetical protein	A0A2K5B270	Erysipelothrix_phage	1.0e-28	43.6
WP_053793944.1\|2191241_2192039_-	phage antirepressor KilAC domain-containing protein	A0A1Q1PVZ8	Staphylococcus_phage	2.6e-49	43.7
WP_080999287.1\|2192394_2193255_+	Abi family protein	A3QSC6	Clostridium_virus	4.2e-21	28.1
WP_053793946.1\|2193267_2195217_-	DNA polymerase	A0A1W6JQ98	Corynebacterium_phage	1.3e-203	54.6
WP_053793947.1\|2195312_2195864_-	DUF2815 family protein	A0A2K5B2A9	Erysipelothrix_phage	2.6e-64	66.7
WP_053793948.1\|2195881_2197015_-	DUF2800 domain-containing protein	A0A1W6JQ97	Corynebacterium_phage	4.7e-121	61.0
WP_053794064.1\|2197007_2197373_-	hypothetical protein	NA	NA	NA	NA
WP_053793949.1\|2197417_2197714_-	hypothetical protein	NA	NA	NA	NA
WP_053793950.1\|2197800_2198409_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_126920325.1\|2198897_2199656_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_080999258.1\|2199776_2201324_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_011152926.1\|2201362_2201410_+	erythromycin resistance leader peptide	NA	NA	NA	NA
WP_011152925.1\|2201509_2202364_+	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(X)	E4ZFQ0	Streptococcus_phage	1.2e-12	27.6
WP_080999258.1\|2202724_2204272_+\|transposase	IS1634 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage