CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP012604	Leptospira interrogans serovar Hardjo str. Norma isolate Cattle chromosome II, complete sequence	0 crisprs	csa3	0	0	0	0
NZ_CP012603	Leptospira interrogans serovar Hardjo str. Norma isolate Cattle chromosome I, complete sequence	17 crisprs	WYL,csa3,DinG,cas3,RT,DEDDh,cas6,cas1,cas2,cas8b3,cas7,cas5,cas8c,cas4,Cas9_archaeal	1	12	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012603_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_1

1231636-1231738

Orphan

Consensus_repeat	Method
CTCTTAGAACGATCAAGATTTTGATATGAAATTAAAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012603_1

>merge|NZ_CP012603|1|1231636-1231738|CRISPRCasFinder
CTCTTAGAACGATCAAGATTTTGATATGAAATTAAAAAATGCAGTAGTTCCCACAGAATTACGTCTCTTAAAACGATCAAGATTTTGATATGAAATTAAAAAA

>NZ_CP012603|1|1|1231636-1231738|CRISPRCasFinder
CTCTTAGAACGATCAAGATTTTGATATGAAATTAAAAAA	TGCAGTAGTTCCCACAGAATTACGT
CTCTTAAAACGATCAAGATTTTGATATGAAATTAAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_002187436.1\|1222210_1223245_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377013
NZ_CP012603.1\|WP_001001361.1\|1230483_1230915_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379324
NZ_CP012603.1\|WP_001045091.1\|1236971_1237718_+\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|273139
NZ_CP012603.1\|WP_000508810.1\|1232114_1233284_+\|DUF1577-domain-containing-protein	unknown	unknown	gnl\|CDD\|369443
NZ_CP012603.1\|WP_000079210.1\|1225687_1226590_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275263
NZ_CP012603.1\|WP_000377363.1\|1226567_1227287_-\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|132880
NZ_CP012603.1\|WP_000459252.1\|1241771_1242710_+\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
NZ_CP012603.1\|WP_025177634.1\|1220473_1222204_-\|apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|234721
NZ_CP012603.1\|WP_000365021.1\|1227426_1229127_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173838
NZ_CP012603.1\|WP_000493049.1\|1229297_1229963_-\|protein-L-isoaspartate-O-methyltransferase	unknown	unknown	gnl\|CDD\|178974
NZ_CP012603.1\|WP_000833715.1\|1239838_1241767_+\|protein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
NZ_CP012603.1\|WP_000723997.1\|1239081_1239828_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275213
NZ_CP012603.1\|WP_000421041.1\|1223331_1224351_+\|4-phosphoerythronate-dehydrogenase	unknown	unknown	gnl\|CDD\|240635
NZ_CP012603.1\|WP_000876121.1\|1230141_1230384_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000196651.1\|1233742_1234516_+\|outer-membrane-lipoprotein-carrier-protein-LolA	unknown	unknown	gnl\|CDD\|319983
NZ_CP012603.1\|WP_000358329.1\|1235661_1236975_+\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl\|CDD\|223694
NZ_CP012603.1\|WP_001072287.1\|1234537_1235653_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379173
NZ_CP012603.1\|WP_000141830.1\|1238758_1239085_+\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|376903
NZ_CP012603.1\|WP_000433680.1\|1237692_1238703_+\|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234682
NZ_CP012603.1\|WP_000944038.1\|1219703_1220474_-\|exonuclease	unknown	unknown	gnl\|CDD\|379215

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_002187436.1\|1222210_1223245_-\|hypothetical-protein	gnl\|CDD\|377013	pfam03280, Lipase_chap, Proteobacterial lipase chaperone protein.	8.69416e-08
NZ_CP012603.1\|WP_001001361.1\|1230483_1230915_+\|ATP-binding-protein	gnl\|CDD\|379324	pfam13671, AAA_33, AAA domain. This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	1.41408e-13
NZ_CP012603.1\|WP_001045091.1\|1236971_1237718_+\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl\|CDD\|273139	TIGR00560, pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis].	4.27529e-35
NZ_CP012603.1\|WP_000508810.1\|1232114_1233284_+\|DUF1577-domain-containing-protein	gnl\|CDD\|369443	pfam07614, DUF1577, Protein of unknown function (DUF1577). A family of hypothetical proteins in Leptospira interrogans.	1.24948e-102
NZ_CP012603.1\|WP_000079210.1\|1225687_1226590_-\|radical-SAM-protein	gnl\|CDD\|275263	TIGR04470, hypothetical_protein_ALIPUT_00462, radical SAM mobile pair protein B. Members of this family are the downstream member (B) of a pair of tandem-encoded radical SAM enzymes. Most of these radical SAM gene pairs have an additional upstream regulatory gene in the MarR family. Examples of high sequence identity (over 96 percent) from cassettes in several Treponema species of the oral cavity to those in multiple Firmicutes in the gut microbiome suggest recent lateral gene transfer, as might be expected for antibiotic resistance genes. The function is unknown.	1.56313e-20
NZ_CP012603.1\|WP_000377363.1\|1226567_1227287_-\|DNA-alkylation-repair-protein	gnl\|CDD\|132880	cd06561, AlkD_like, A new structural DNA glycosylase. This domain represents a new and uncharacterized structural superfamily of DNA glycosylases that form an alpha-alpha superhelix fold that are not belong to the identified five structural DNA glycosylase superfamilies (UDG, AAG/MNPG, MutM/Fpg and helix-hairpin-helix). DNA glycosylases removing alkylated base residues have been identified in all organisms investigated and may be universally present in nature. DNA glycosylases catalyze the first step in Base Excision Repair (BER) pathway by cleaving damaged DNA bases within double strand DNA to produce an abasic site. The resulting abasic site is further processed by AP endonuclease, phosphodiesterase, DNA polymerases, and DNA ligase functions to restore the DNA to an undamaged state. All glycosylase examined to date utilize a similar strategy for binding DNA and base flipping despite their structural diversity.	3.37587e-09
NZ_CP012603.1\|WP_000459252.1\|1241771_1242710_+\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	1.44272e-88
NZ_CP012603.1\|WP_025177634.1\|1220473_1222204_-\|apolipoprotein-N-acyltransferase	gnl\|CDD\|234721	PRK00302, lnt, apolipoprotein N-acyltransferase; Reviewed.	2.97299e-61
NZ_CP012603.1\|WP_000365021.1\|1227426_1229127_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	8.20482e-42
NZ_CP012603.1\|WP_000833715.1\|1239838_1241767_+\|protein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	2.95752e-150
NZ_CP012603.1\|WP_000723997.1\|1239081_1239828_+\|hypothetical-protein	gnl\|CDD\|275213	TIGR04420, Sec_Non_Glob, Sec region non-globular protein. Members of this family occur only in the genus Leptospira, always encoded between genes for the YajC and SecD components of the Sec preprotein translocase. Sequences have an N-terminal signal peptide and a C-terminal transmembrane segment. Between these are regions of non-globular, low-complexity sequence including Lys-rich and Ser/Thr/Asn/Glu-rich regions.	6.82364e-87
NZ_CP012603.1\|WP_000421041.1\|1223331_1224351_+\|4-phosphoerythronate-dehydrogenase	gnl\|CDD\|240635	cd12158, ErythrP_dh, D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains. D-Erythronate-4-phosphate Dehydrogenase (E. coli gene PdxB), a D-specific 2-hydroxyacid dehydrogenase family member, catalyzes the NAD-dependent oxidation of erythronate-4-phosphate, which is followed by transamination to form 4-hydroxy-L-threonine-4-phosphate within the de novo biosynthesis pathway of vitamin B6. D-Erythronate-4-phosphate dehydrogenase has the common architecture shared with D-isomer specific 2-hydroxyacid dehydrogenases but contains an additional C-terminal dimerization domain in addition to an NAD-binding domain and the "lid" domain. The lid domain corresponds to the catalytic domain of phosphoglycerate dehydrogenase and other proteins of the D-isomer specific 2-hydroxyacid dehydrogenase family, which include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence.	8.91783e-107
NZ_CP012603.1\|WP_000493049.1\|1229297_1229963_-\|protein-L-isoaspartate-O-methyltransferase	gnl\|CDD\|178974	PRK00312, pcm, protein-L-isoaspartate(D-aspartate) O-methyltransferase.	2.53546e-55
NZ_CP012603.1\|WP_000196651.1\|1233742_1234516_+\|outer-membrane-lipoprotein-carrier-protein-LolA	gnl\|CDD\|319983	cd16325, LolA, LolA, a periplasmic chaperone. This family contains periplasmic molecular chaperone LolA which binds to outer-membrane specific lipoproteins and transports them from inner membrane to outer membrane (OM) through LolB, a lipoprotein anchored to outer membranes. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts OM-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. Studies have shown that hydrophobic surface patches large enough to accommodate acyl chains of the OM lipoproteins and the structural flexibility of LolA are important factors for its role as a periplasmic chaperone.	1.73701e-24
NZ_CP012603.1\|WP_000358329.1\|1235661_1236975_+\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	gnl\|CDD\|223694	COG0621, MiaB, 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis].	1.1642e-119
NZ_CP012603.1\|WP_001072287.1\|1234537_1235653_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379173	pfam13413, HTH_25, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.16019e-20
NZ_CP012603.1\|WP_000141830.1\|1238758_1239085_+\|preprotein-translocase-subunit-YajC	gnl\|CDD\|376903	pfam02699, YajC, Preprotein translocase subunit. See.	1.26653e-26
NZ_CP012603.1\|WP_000433680.1\|1237692_1238703_+\|anthranilate-phosphoribosyltransferase	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	7.96128e-154
NZ_CP012603.1\|WP_000944038.1\|1219703_1220474_-\|exonuclease	gnl\|CDD\|379215	pfam13482, RNase_H_2, RNase_H superfamily.	5.30157e-30

>NZ_CP012603.1|WP_001001361.1|1230483_1230915_+|ATP-binding-protein
MNEEKSLILLRGLPGAGKSRLAKLLSENGKYPVFSVDDYFTDSKTQEYNFDYKKNHLAYKHCEDCVRKEAERGTSKIFSDNTFTLSWEMEPYFQIASEFEYTIFVITVENYHNGKNVHSIDDESLKKMASKYKIRLLPEILSE
>NZ_CP012603.1|WP_000876121.1|1230141_1230384_-|hypothetical-protein
MKYLETEQIIPSKGMSYTMYEVEGEDQIQKMMTYIPNTDEIHIYPKPPVKKLYKPELCKVIDEVVFSELWKLGEERKAAK
>NZ_CP012603.1|WP_000493049.1|1229297_1229963_-|protein-L-isoaspartate-O-methyltransferase
MFSSSKVCNPILREQERKNMVDLQIASRGIRDKKILSAMLSIPRECFVPNSHILQAYEDKPLPIGCNQTISQPFMVAWMSLLLEVRKGDRIFEIGTGSGYQSAVLIFLEATLYSVEFFDSLSKTATQNLECWNPGCTQTNRFMIGSATEILKPELQFDKMISCAALPNLPDTKSSYFQSLIPGGIFIFPMGKRDQSLIFAKRNLNDWSFESKGGVRFVPLL
>NZ_CP012603.1|WP_000365021.1|1227426_1229127_-|acyl-CoA-dehydrogenase
MDLLNPKKTEFKHLDEKSRNIMKRTIAFFEKKGKNKLKEDDRNQTWYADFLEFQKSEKIFATLMTPSGYGENDSRWDTTRICDFNEIAGFYGLCYWYTWQVSMLGLGPIWNSKNEEIKHKTAKLLLDGEIFAFGLSEKEHGADLISSDMSLENKGNGNYIANGRKYYIGNSNKAAIVSTFGKMKDTGNYVFFAVNSGHKNYELIQNVVNSQSYVGEYALKDYPISEKEILSKDREAWDASLSTIAVCKYNLGWASIGICTHSFYEALNHASKRKLFNRNVTDFSQIKQMFVDAYCRLFSMKLFAARAKDYMRSASATDRRYLLFNPMVKMKVTMQGEEVINLLWDVIAAKGFEKNMYFEMAAKDIRGLPKLEGTAHVNMALIIKFMNNYFFEPNSSLPVVPKIDDFKNDDFLFNQGTTSKGFEKITFRDYNEVYSNIDLPNVLIFRKQIAVLKEFLKSTPPDSKQSKDLDFMLILGELFTLVAYGQLLIENAAIEKVDNDLLDQIFDFMVRDCSKYALQLYSKRSSTKEQMEKCLAMIFKPAENEELFNRVCAKVYSYKDAYEMAP
>NZ_CP012603.1|WP_000377363.1|1226567_1227287_-|DNA-alkylation-repair-protein
MDSIRSKKEIKLILSKLSDSDESLWIFIIESELLKKKIKFPLLEFVGKELYFKIPEMNQIYFTDQIIKLGHMGGYVISAIILQLRMEKHFEQSLNKAVEYILLGNEWYVCDIIGERIMGYFLLKEPEKTLPILKNYINDKNGWIVRSVGVASHYAVKKGLGKKYVEVTFYLLLSKTDTKDFHTKKGIGWALKTISKFYPDIIQKFESNLLANPSIQPFFRKKIEIGLSRSSKYGSKYSD
>NZ_CP012603.1|WP_000079210.1|1225687_1226590_-|radical-SAM-protein
MAQSIRIKNILNKTKRRDPWFLDDYTINPYSGCSFRCLYCYVKGSKYGLNVEDKLSIKENAVEILDKQLSNLAKKNRHGIIVLSSATDPYLQLEKERGLTRELLKIILKYKFPVHILTKSDLILRDLDLLSEIEKNAILPVDLQNQLSRKSFITFSFSILDDSIAKIFEPGATSPSLRISALKETLKEGFFSGVSLMPLLPHISDTGENLEFMFQTFQEIGIRYIFPASLTLFGGNDPLDHKNLIFKAIENHFPHLLSKYQKFFSKNFRMPNFYQNALYHKTSELCSKYGLQKGILTTEF
>NZ_CP012603.1|WP_000421041.1|1223331_1224351_+|4-phosphoerythronate-dehydrogenase
MELKKPILYYPEGTIGAKEIFSSFEKLEVRSYPNDRIREISRDEPTILIANTRFQVNRDNIQNFPTVKIFATVSSGTDHVDFNALKEFKKIFLNAPGCNAGSVAEYCFAGLLNRFKESELKGLKIGLVGHGHTGKEFYKILISKGVNCIFYDPFYKTESRPLSEVLDASVLSFHVPLTKDGPEPTFRFVSTSLIDSLKSGTIFINTSRGEILSREAFNRLIARNDIFKILDVFDPEPPTLEMGRKLSEVKHSILTPHVAGYSQLGRIGGTYRVAEKLSILYQDKPLPPLNFFLQTSGEFKTSTFLKEEDRLLREAWRNGDTNYFEKRRNTYPIRLDWDF
>NZ_CP012603.1|WP_002187436.1|1222210_1223245_-|hypothetical-protein
MKTLQQKITFPILVGLISVTLIMLIWFVFFSGSKITTSSSASLDPESSSGSEGWILNQAIINTSRRIFDENGNWLSFDELIQYASNGEINLISELSDLRRQCPENIHYEQCNEIIRAFIADHYFGKDAEYLMKLFSSYLKYETKMKELEISDKLSRAEKYELIKKQRREFFSDKDTKLIFGLEEAEETYLDSLGGFLKDTETLSGEQRMQKYEEFRKNVYGQYYNTIKKREPKYNTYETEMFLREKELERMSSSERNSKTRHIREKYFGKDGADRMETVYQESEEKEKKEKQTAQEESDWIRKNPNVKVEIKEKALMEIRIKNLGKEEAEEYSRRLKYEEEIKK
>NZ_CP012603.1|WP_025177634.1|1220473_1222204_-|apolipoprotein-N-acyltransferase
MFYNFISKDSILYRLILCFGIGIGTVFGLSPFSFFSAGVFASISCIFLFFSLNRTSIWKAFLWLLILSQILNFTAFYWIPGAISRISGANTFVSILFFFLYGLISHLKFFLFYTLFRFSKIDSASKTYILLIFPAAGTLSDMITFQIFPWYWGNLISGSIVFEQFASICGVYGLSFLLLFISSTFLILVNYYKYKNSKEFKTSIASLICIAFIYGFGLYRIGYINQSQNELKPKNLSVLMIQPDTSPGTKDLKADASYLSATMSKVFSLAIPTFENSPSLIVIPESAIPFHGTIDSEENRKEKIYSSTMEGIVLYLSKHTGADVLFNELNLDENKLRNQVSLFKNLDGKTERYNKRRLLPFGEYLPMEKNFPFLRSIFQETSRYVPGEFPKLLIGNKIQNQRSFLPPEISKLNEPKTYRYEFSSIVEHTNKIRNLEYSYSILPLLCYEAMFTELVLDYFQNEQKPEVLINITNDSWFDSELEAYQHSGAVRLRAIETGLPLIRSAVSGISEVWDARGIPMIVPIGFHETGTRAFSIRLDAIESTIYTRFGNSFLWIFCILILISRLIFVSRIERKS
>NZ_CP012603.1|WP_000944038.1|1219703_1220474_-|exonuclease
MLRHTFCHLPGIDSKEEKNLWEKGIYDWKDLEIYLKTEPAPIRNLILDALEFSKKELERENFFYFFHVFSPKHHWRLFPTIRKKLLYMDIETTGLGNDDRTTVIGTFDGYEYRSYIRGFNLDFFLENLSQDQIFVSYNGIAFDVPFLEREFNVRFRNNHIDIMFFLRSLGIRGGLKGCEKTLGVHRPETAAITGIEAVNLWKQYVDYDDMDALKILEEYNREDTVNLEILFIKGYNLKIKETPFYGEVIQEPLQLR
>NZ_CP012603.1|WP_000508810.1|1232114_1233284_+|DUF1577-domain-containing-protein
MGGIKLKERDLDVINSPEQRKHIIEKHLLNQSLRIKGDLNRETITIQRYVDSGEKIIAGISDETHFSENDEIVLYKILAKYVQLECSFIRKTRPGVAEFSVNKVSIAKSNRAFPRYSVAEDAAHVTNINSSKTVIDASLFNIPTLVKVSFEDYKTKLKPDQLGLVEIDVFRSDQDEKFELIKRTKKYIHIENTSLEESYKSKSENQVDVEDEIHEEIPSLMRKYKDEKIVSEIIYPIIYINHSRQSIPLGYIWVRNKEKTLGNNTIEKLAELSKEMVARIKESNTVLTTEKFPIIDISNNGICIKITEPHLIQTLPKHTGFVFDIYIRMQGYFKVFGAIRWLSYDEVGSLILGMELVAKSSFPGEREKFHRNVELLGQGKFTGLKTHAI
>NZ_CP012603.1|WP_000196651.1|1233742_1234516_+|outer-membrane-lipoprotein-carrier-protein-LolA
MTRFPRHLILVKKIPGDPVFLMKKTIILSFFILFLALEPSLLAQPAHNWNSPSEVVKQVKKKFSDLNSYKADFQIQTVSNKKSKNMKGVCLYKKGGRIRYQFNEPSGDEIVSDGKTLYIYIARLNAVGKQDLTLNKSNKSGPIFSNFTDEGLSRIFRKYHYKFDSIEQPQTSSKDGRKYFVLNLEQREKIGGFETMLLYVDAQTYFIQKAVASDGRGKETTIEFSNLEINPDLEDGQFNFHIGGNAKIINNPLVSEQ
>NZ_CP012603.1|WP_001072287.1|1234537_1235653_+|helix-turn-helix-domain-containing-protein
MNQKRVGQILREAREEKKLSVKDVARETNISVKYILALETEDYSQFPGETFTMGFLKNYGGYLKLDTGQLINLYRGEKIEESQAPLEELTRPTASYYTKINVDKNKIFTIASVLIILISAYLIIDSFIGPSSDEDSVEESGKKLDIPENIDFLSRSIPENRSESFILTPDKGVSFSVSNQQCKLFIDSVEKGGAVNTAVLAFNVYPELTVYKFRLSEGQEKILSYTIPEISSLRRNVRIISQAVTENSAKVLVTLSDEEQKQENNNSVDNTKTLGDVPIQVTLFFNKPSYAEFIIDGQMGFRGLVQTGETRSLEAKDRLELKVGDGSAVEMIQNGKPKITLGRPGKLVKKIFVKTQNPYDSTQSIIKELGE
>NZ_CP012603.1|WP_000358329.1|1235661_1236975_+|30S-ribosomal-protein-S12-methylthiotransferase-RimO
MDKKFYITTLGCPKNIADSMSMHHSLLEEGFTPASLPEESDFHFINTCTFIQSATEETIQTILSAAQVKKQNHQKLVVVGCFAERYPDNIHSEIPEVDLFFGTGKYSQAGKILREKFPELSPSQLEFNDSLLERWKLSSKIENYSKPYAYVKVSDGCNRGCSFCIIPSFRGKFVESPLDDILRDTNRAIRAGAKEICLVSQDTVYYGRDSEILLDMVRKVAEIDSLEILRLLYLYPDKKTEKLIRLMGETSKIAPYLESPLQHVSSKILKVMNRTGESSYFKDLFSLAREVKPGLEIRTSFIIGYPGEEPEDVDQILRFIEDTRPEKVNLFSYSPQEGTKGAQLKQTVSEKEKSKRINLIRDSHLEILEEIHESRIGRTYDAIVDGIEDGQVVVRRFQDAPEMDEVVYVDDVSLLPGRIGKVRIDSFYEYDMNGTWV
>NZ_CP012603.1|WP_001045091.1|1236971_1237718_+|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MNKVIFNIPNILTMLRVAAVPFFVWFLFQKELEYHIAALILFSVASLTDLIDGYLARKWNQETEFGKFLDPLADKIIVTGCFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQGQSIRTTMLGKVKTVFQMGAIVLILVFFILISSKKRILINQAYATGKANGLTVFEFATNNAIQFFRNLDQNNGLGDVVFGLGTFVPYWGMLVTTTITVISGIRYLVSNSKVLYPSNLKGMFQKNGTKSSRS
>NZ_CP012603.1|WP_000433680.1|1237692_1238703_+|anthranilate-phosphoribosyltransferase
MEPRAAVLKLIEHKHLTALEAESFMNHVMKGEVSEILLSSFLTAMRFNGESVEEVLGCTLALRKNALRPKTVFPFDLLDTCGTGGDGQGTINISTLSAIVLASLGIKVAKHGNRSVSSHTGSSDILTRLGYQTETTQEEVEAHLVNRGFTFLFAPMWHPSMKHAGPVRKELGFRTVFNMIGPLSNPFSPQFQIIGVYQPELMELFIKVLQSLGLKRALVCHSRDGLDEFSIFQITDYTFLENGVISRHSFDPKILGLSSLNKEEVYASSSDHAEVLARKVLNSESIAGTHAVALNAGAGLFVMGKIDTIEQGYQIAKEAILSGKTKKYFEDLISKE
>NZ_CP012603.1|WP_000141830.1|1238758_1239085_+|preprotein-translocase-subunit-YajC
MTFDILLQLAQAAGEGDKSPFSTLLLIPIMLVIMYFLVIRPQRNEEKKRKEMIDSLKKGDEVVTSSGIHGKVVEIKDNNEVVVLNIAKDTNVSFTASTVLKKKQQADK
>NZ_CP012603.1|WP_000723997.1|1239081_1239828_+|hypothetical-protein
MKKISILILIFLFLGNLALFSQDGEEIDFLEKVTEPKKTVSKKSSNTAGASSGTSTPKKKEKKRSKKKRSKKSSSSIPNNLEETQKKNVIPNTNETSSGNNNSNLNGSNSGSSNTLESGNVDEQRVSASKMDLRDLPKPYWVNEEVQIHPNNLPGYTVSQKSEQGSSFGSGLSEILKLGEDKKKEENKKKVQEVQKSGSFTGFISEYKKPIIIIVFILLFALYRLKAGKSRGSSSRKSPVTINKMRRD
>NZ_CP012603.1|WP_000833715.1|1239838_1241767_+|protein-translocase-subunit-SecD
MKSATWIFLPLLIILAATVILYPNFATRELELAVRKEFISISPEQKKAILSRFEERWNREYKQSDWVISPSPSELKDESFLLVKGRFITSAKINQISQENPELILEAKNKLRPTLVEEWITKGRPLTIKLGLDLQGGMRVAMKGDFEDYASKLRESYIKEIENLNKTVTDPSADEKEKKKAKDRLSEIESYFELSPSRKLLELEKAKLIIDNRLTSQNLTEPQVRIQKDQDSIEVSLPGVTNSSQILEIIQNTETVEYRLEEPENSAGNGLTYASIIQQEENRLLELKRREETDIVQYQNIIKQKLGKAEQDKFLQGLEEKYKIPRDRYRVFAYWARGNHQNSTLLPRKFVVLEKAIALDGRDMRDARPSFENNSFGYIVSFTLTSSGAEKFFEITSQNKGRNLAIVWGDKVVSAPTIRSAIAGGVAQIDGSFTKEEAVDLANVISEGALPIPLRVLEMRFIGPTLGIESIEVGMKAVLIGFVLVMFYMILIYRLSGLVANAALFANIVILSALLSLMGFTLTLPGFAGIILTVGMAVDANVIIYERIKEELRAGKSATVAVAQGFDNAFWTIIDSNVTTLISGILMIRLGNGPIKGFAITLCWGIITSLFTSLFLSRLVMDLLVNRLGVQKLQLGFKKLES
>NZ_CP012603.1|WP_000459252.1|1241771_1242710_+|protein-translocase-subunit-SecF
MFDFIKYKYVSICISLALIVFGFSYTYAVHGGFANSLDFNGGLRTVVEFDQNMDRKKLENYFAENKIEAVLLLLDKEKHHYQIDIGLGSVDSILLKYREKNGLKPTDKVELSGIDALISILIADFRIDKSNILSANQVGAIVGGELSSTGTTLLGLTMAIILAYISFRFQFKFALGAILALTHDLILTVAFIGFFQIKPSVPIIAALLTLLGYSINDTIVVFDRIRENSAGNLNQTFGQTINSAINQTLGRTFNTSFATLISIVAIIIGGATELFDFAYVLTFGIVIGTYSSIFIAAPLVDIYDQVIRKARD

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Crispr_ID: NZ_CP012603_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_2

2471280-2471379

Orphan

Consensus_repeat	Method
TTAGTGGTAGTTCTCACATTTTAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012603_2

>merge|NZ_CP012603|2|2471280-2471379|CRISPRCasFinder
TTAGTGGTAGTTCTCACATTTTAGTGTAAATCTTTGACTTAGTGGTAGTTCCCACATTTTAGTGTAAATCTTTGACTTAGTGGTAGTTCCCACATTTTAG

>NZ_CP012603|2|2|2471280-2471379|CRISPRCasFinder
TTAGTGGTAGTTCTCACATTTTAG	TGTAAATCTTTGACTTAGTGGTAGTTCCCACATTTTAGTGTAAATCTTTGAC
TTAGTGGTAGTTCCCACATTTTAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_002187452.1\|2483931_2485218_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275380
NZ_CP012603.1\|WP_001281423.1\|2466787_2467468_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188258.1\|2458549_2461294_-\|biotin-requiring-enzyme	unknown	unknown	gnl\|CDD\|236307
NZ_CP012603.1\|WP_002187461.1\|2482280_2483861_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215061
NZ_CP012603.1\|WP_000004280.1\|2466188_2466497_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002187497.1\|2487585_2488020_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001973770.1\|2461300_2462953_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit	unknown	unknown	gnl\|CDD\|227136
NZ_CP012603.1\|WP_000616854.1\|2456676_2457720_+\|chemotaxis-response-regulator-protein-glutamate-methylesterase	unknown	unknown	gnl\|CDD\|234828
NZ_CP012603.1\|WP_025180781.1\|2458137_2458476_+\|YceK/YidQ-family-lipoprotein	unknown	unknown	gnl\|CDD\|227932
NZ_CP012603.1\|WP_000915022.1\|2480821_2481793_-\|membrane-protein	unknown	unknown	gnl\|CDD\|275130
NZ_CP012603.1\|WP_002187492.1\|2486626_2487565_-\|tRNA-epoxyqueuosine(34)-reductase-QueG	unknown	unknown	gnl\|CDD\|272993
NZ_CP012603.1\|WP_000116243.1\|2467470_2468007_+\|peptide-deformylase	unknown	unknown	gnl\|CDD\|237227
NZ_CP012603.1\|WP_002187457.1\|2477707_2479924_-\|leucine-rich-repeat-protein	unknown	unknown	gnl\|CDD\|215061
NZ_CP012603.1\|WP_000839353.1\|2468026_2471269_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP012603.1\|WP_001971044.1\|2476036_2477110_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000406879.1\|2463044_2463374_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP012603.1\|WP_025177636.1\|2485427_2486273_-\|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|275380
NZ_CP012603.1\|WP_000612757.1\|2463357_2466174_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP012603.1\|WP_100225741.1\|2477181_2477376_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001080347.1\|2471384_2472467_-\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|377164

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_002187452.1\|2483931_2485218_-\|hypothetical-protein	gnl\|CDD\|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	1.29771e-44
NZ_CP012603.1\|WP_002188258.1\|2458549_2461294_-\|biotin-requiring-enzyme	gnl\|CDD\|236307	PRK08591, PRK08591, acetyl-CoA carboxylase biotin carboxylase subunit; Validated.	1.02425e-44
NZ_CP012603.1\|WP_002187461.1\|2482280_2483861_-\|hypothetical-protein	gnl\|CDD\|215061	PLN00113, PLN00113, leucine-rich repeat receptor-like protein kinase; Provisional.	1.22433e-38
NZ_CP012603.1\|WP_000616854.1\|2456676_2457720_+\|chemotaxis-response-regulator-protein-glutamate-methylesterase	gnl\|CDD\|234828	PRK00742, PRK00742, chemotaxis-specific protein-glutamate methyltransferase CheB.	2.87962e-174
NZ_CP012603.1\|WP_000116243.1\|2467470_2468007_+\|peptide-deformylase	gnl\|CDD\|237227	PRK12846, PRK12846, peptide deformylase; Reviewed.	6.93109e-80
NZ_CP012603.1\|WP_001971044.1\|2476036_2477110_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27
NZ_CP012603.1\|WP_000915022.1\|2480821_2481793_-\|membrane-protein	gnl\|CDD\|275130	TIGR04327, hypothetical_protein_LlicsVM_10020, outer membrane protein, LA_2444/LA_4059 family. Members of this family are predicted outer membrane proteins, apparently restricted to the Leptospiraceae (Leptospira and Leptonema).	2.03606e-103
NZ_CP012603.1\|WP_002187492.1\|2486626_2487565_-\|tRNA-epoxyqueuosine(34)-reductase-QueG	gnl\|CDD\|272993	TIGR00276, iron-sulfur_cluster-binding_protein, epoxyqueuosine reductase. This model was rebuilt to exclude archaeal homologs, now that there is new information that bacterial members are epoxyqueuosine reductase, QueG, involved in queuosine biosynthesis for tRNA maturation. [Protein synthesis, tRNA and rRNA base modification].	1.09992e-79
NZ_CP012603.1\|WP_001973770.1\|2461300_2462953_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	3.23486e-128
NZ_CP012603.1\|WP_002187457.1\|2477707_2479924_-\|leucine-rich-repeat-protein	gnl\|CDD\|215061	PLN00113, PLN00113, leucine-rich repeat receptor-like protein kinase; Provisional.	3.05488e-41
NZ_CP012603.1\|WP_000839353.1\|2468026_2471269_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP012603.1\|WP_025180781.1\|2458137_2458476_+\|YceK/YidQ-family-lipoprotein	gnl\|CDD\|227932	COG5645, COG5645, Predicted periplasmic lipoprotein [General function prediction only].	0.00172596
NZ_CP012603.1\|WP_000406879.1\|2463044_2463374_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	4.89607e-25
NZ_CP012603.1\|WP_025177636.1\|2485427_2486273_-\|leucine-rich-repeat-domain-containing-protein	gnl\|CDD\|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	3.93551e-41
NZ_CP012603.1\|WP_000612757.1\|2463357_2466174_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	7.32649e-56
NZ_CP012603.1\|WP_001080347.1\|2471384_2472467_-\|PepSY-domain-containing-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	1.95887e-51

>NZ_CP012603.1|WP_000839353.1|2468026_2471269_+|efflux-RND-transporter-permease-subunit
MKSLVEFFLSKSIFVNLLTFLVILIGGFTAVKMNREAFPNINFDIVSVVTVFPGASPSEMEKLVTKPLEEAIQEVDGIKEFRSASIENRSGIVITLDPDSKNTQKVVDDIKSAIDRVEDLPEEAEDPIVTEITTSRQPVIEINISLKSNDSSIEAEKHLKAQAKIVEQALEDIPGVARISKRGWRDTEMQVDIDPVAMFSKYLTSQDIIFALKNRNINFPGGNIAGNQKEVILRTIGEFNSPKEIETVHVRSNEVGNSIRIDNVARVTEGLKEAEYLDKVNGKKTIALTVIKREKADAILVVDEAKKIIEEFKKNSKNEFEYAFVNDLSKYIRRRLGVLLSNAIGGLILVTASLFLFLGWRVALMTALGIPVSFGATFVIMDYLGLTLNLISMFGLIIVVGILVDDAIIICENVYRYMEEGMPAYEAALKGTSEVIDPVTATVTTTVAAFAPMLFMTGIFGKFIYSIPLVVIIALLASLSEAFFILPSHLYDINKHKFHSGEIKEESGWFYKLKVNYYLPLLKFALKHRLQIFIYLFAMLVGSFALFAVFGRFKLFPGSVDVFQIKLTGQTGISLQEMEKFTHALETELAKISKEEIENYVTRVGIIQKDPNDPFTKRGKHYAQVLVYMTPEENRKRGTDTIISEIREKTIWLLNEKSVKTLEETRKKEAEKKKEEYKPFNLNEYPAEFSRFKGQLLALDFEKLAGGPPVGKPVAIEIRGDDYDTLIRIGEEYKSVMAKVPGVTDIGDDFNEGKDEIRIKVNESLASTAGVSVFKVAQAINTAFQGTVATKIKRADEEVEVKVRFPEEVRKSIGSLNNIFVSNQLGKLIPVSRLINYVREPGFANINHLDGKRLLTVTANLDEIKTDTRRANAEIAKLSKGIIDKYPGYRMRFGGENKDTEESLASLGRAFLVAFIIIFMILASLFRSLIQPVIVVSSIPFSLIGVILAFVLHGEYFGFLAFLGIVGLAGVVVNDSIVLVDFANQLKLEKPGEDIDSILVETGLLRLRPVVLTTVTTVLGLLPTAYGIGGKDPFLVPMALAFGWGLAFSSFLTLVAVPVLYKTVHNVQLKINRVFLKSKR
>NZ_CP012603.1|WP_000116243.1|2467470_2468007_+|peptide-deformylase
MSVRKILRMGDPILRKISEPVTEDEIQTKEFKKLIRDMFDTMRHAEGVGLAAPQIGILKQIVVVGSEDNERYPGTPDVPERIILNPVITPLTKDTSGFWEGCLSVPGMRGYVERPNQIRMQWMDEKGNQFDETIDGYKAIVYQHECDHLQGILYVDRLKDTKLFGFNETLDSSHNVLD
>NZ_CP012603.1|WP_001281423.1|2466787_2467468_+|hypothetical-protein
MSDLIQIRRWNIDNKNVLILIPDLESKERQLYAKNFYSHFSIREVELSTKLVRFDFPKTEEWIDRLSREILDSKRKVKLIGEGLWGGIVFELLKKYPQMIEAACILNPPLNRKEENWFPKNVEWILERFPWNLFSEGIYTFYQTLETKLQFGLTNSKLLPTIVFTKTPEKITKQIQTLQKFPVFRIESSNLKSIHELLENLILKILTEVPISSVQKKSKFKIDPGF
>NZ_CP012603.1|WP_000004280.1|2466188_2466497_-|hypothetical-protein
MSESIEDLQKKLKIQNDIIKGYEKVLRLNEQELENADEIIRMYEGIIQYSGKELKDVKEAFDATNVVTNLSREELMSALSRIKELENVNKKLREEALKFQTG
>NZ_CP012603.1|WP_000612757.1|2463357_2466174_-|SpoIIE-family-protein-phosphatase
MIPNKKQDSLLRQGSDGSLYLEDNPGLTVVFESLLTEIIHITSAKFGIFSFRLEDGTLKSIYGNHPSNKIEEAKLVSEFCFKTGQDLNLKKGESPNKLIPQLEQNSVCCVLHVGELGDSSLEDQKKIFGTILLGRSDQEGGEFRESDFIHLKATVRIISDLLEKSFISGESSLVVLSLMTISRVALESVQIRKQTDRFDFLLTEIIRVSGLINKSLDLSQLLEAIMLSSKSVFRTEACSVLLLDDTKEYLYFHTVLGEKRDEVTKVKVPVGKGIAGMVVQDKKPMIINDAMNDPRVYREVDKASHFVTRNIMAAPLLVEGQVIGVIETINTIDRNSFTEEDLELFLSFSGTSALAIQKTGLLQNLEDANKDLRKKVSELESLFELSQVVSSAKSQADLMKHSIPVIHNEMDAGRTGIFLINRRMGLLTCISYTSEKIVEIFRTKDYQGSFIYRSVEEEKTTIKEDIQNFEFNHELDLEFLKGSYIVLPLTNPERNAFGVITVSDRVDKLSYNYSHLRLLQTFASLIARGHETLKLQNEMISRKAMQRSLEREIEITREIQKNILPESKVFHSNFDLGVKSVPAKEVSGDFYDYYQYQDGQYSFLISDVSGKSLPAAIFMAMSSSIIRTLARDHDLDPEEILKQGNALIYEDSHNGMFVTTFFIHYNPAIFTLDYASAGHNDQVLIRKDDSWEIIKGSGPPLGVLPSASYKGGSLTVEPGDMLILYTDGAIEEKNSKDEEFGLERMIREVIARKHLTSQEIVEELFGLVRKFSGAPELFDDFTVMILKFNDNYQFSRIFEAKTSEIPLFREFVYQTIKVRNLEDSQRDDILLACDEAGTNIVMHGYENTDLKNPKFECKIRFTGDWITIVLIDSGKVFHREEVQDPSIEDNLSGKRKGGFGVYLIEKLMDSVDYSSEGGKNFLVLKKNFRNKASNGNNV
>NZ_CP012603.1|WP_000406879.1|2463044_2463374_-|STAS-domain-containing-protein
MEITSEIKNHSKIIHLIGNLDVHNTHKIESAFMEQIKTGNSRVIVLDLSSVEFISSAGLRIIVAALRICREKDVEFRLAGIKPAVKKVFEIIDMNSMFSIFETLESAIK
>NZ_CP012603.1|WP_001973770.1|2461300_2462953_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit
MSEAKYSLENPFQSTSEPEVLKPRGLYEEANELGKELLNKPLLGGGVDRILVQHSKDRMTVWERIKVLTDQEPNILYQNWGKSLDGASLVTGILNINGRDVAVYGHDFTLRAGSMDATNGSKLARLIYMAGEHGIPLIGMNDSAGAYVPAGVGGLDGYSEAFTALRKISGVVPSLMLMFGFNAGGGAYLPRQGSFMIQCDNTFFGLTGPGVVKSVLGEDISADDLGGPKVHGQSGVVDIVTGDELGSLRTALRLLSYLPDNNHSFAPFHATSDPTNRFIYEEEILFKKTFNSPTGMNTPFDITLYLQNICDHGQYFEIQGQRSRNLVTAFGRIGGHVVAFVANNSAVSSGQIDIGAARKGTRFIRFCNLYNIPIVFLEDTTGFLPGKEQEQNGIVLEGRKLLDSIIDIRTPRLTLIIRNAFGGAYACFNSYHTGADMVFALPTARIAVMGPAGKDYVYKDEVSSIQKEYQENVKKGMSEKEAIVIRDKKLQTLSTQYEKELMNPKEALSLGSVSRIVLPGTTRNILFQNLDYLIRHYKPAPLSGPQREFE
>NZ_CP012603.1|WP_002188258.1|2458549_2461294_-|biotin-requiring-enzyme
MIDFQNNRIQFHQSSSPWIRSFSLESIKCLIVCRGPVRKEAMEIFDSIGIREYGILLSEKDSVVYPMALAPELRGFRFPNNIHRVPDYMGAGKEEKMERIEQIISIAKDNKYTHIFAGYGFMAEDSEFISAIEKSGVVFMGPASYVADQAGSKDAAKKIARKLEVSVTPGVDNISSLALLAKAPDAKSLEKIAKEKGIDFIFDPSLSLEVNAENLLELGYSKIIEFVSIADLQVEAEKECKKIWEKYSKNRIRFKYIGGGGGKGQRVVSKPEEVKGAVQEILSESKVTAPGTNKNFLIELNIENTRHNEIQLIGNGEWCLALGGRDCSVQMHEQKLLELSLTQELLEKEIAACAATHPKKAEVLKGDLKVLREMEEQSERFGAAVKLNSVSTFESIVEGTNHFFMEVNTRIQVEHRVTEMVYSLKFKNPENQNEFFIVDSLIEAMALLSLHGKRLQKPERIFRFPSGAEVRINATNKAIQPHAGGVIMNWSKPLADEIRDDQGISIRNPDMGLFVHYKVAGAYDSNIALLISHGENRKDNLIRLGNILRKTELRGYDLQTNLLVHYGLIHWILGKDAMFKPSTSFMISYLAGVGALEKIIKDVDLEIAWKKIISEASADLKKVLSRKLTLITRPIGELIKDAHLSAGFIGFHLNRSWKISDSKIEWLRNPIFILADLYHYLNMEADPSLPPSEQIWDHDDEVLQKALSFYQELAKRTGSNPDSIELVASLNAGKSLNGIEAGLLPSILASHNGYQSGLELLKLLPYAGLNSGFYKLEVDEKLEAVIPEEFRKTETRDSLIKFLAPPPKASSDEIVAPMGGMFYSKEAPDLPPMIKVGDHFKAGQPLFIVEVMKMFNKISAPFSGTVKEILLNDSDGKIISKGQTIFKIVPDEVIHIETEAEITERKKKITLSLI
>NZ_CP012603.1|WP_025180781.1|2458137_2458476_+|YceK/YidQ-family-lipoprotein
MRIKPFFLILIVLQISIFLNCGTIFGIFQTYSYEKRMENRKSSMILGMPTDHSPIFAGVNFEYSMMKFLKAENIYFYLLILDFPLTILMDTVFLPISVPLSIHHYYKDKQQP
>NZ_CP012603.1|WP_000616854.1|2456676_2457720_+|chemotaxis-response-regulator-protein-glutamate-methylesterase
MIQVFIVDDSAVVRQVLTQILNKDPEIEIIGFASDPIFASEKLSSVWPDVFILDIEMPRMDGISFLKKIMSEKPTPVIICSSLAEKESETAVLAMKLGAVDIIEKPKVGLKNFLEESEILFIDSVRAASNARVKTHSFQNDDSKFLENHKQPKTDFSKIDTTDKLIAIGTSTGGTQALEFILTQLNIHCPGIVIVQHMPEKFTEAFANRLNQVCKIQVKEAKDGDRVQLGSAYIAPGNKHMEIYLSGAQFHIRVLDGPLVNRHRPSVDTLFHSVAKAAGKNAKGIIMTGMGNDGANGLLKMKQSGAHTIAQDEASCVVFGMPKEAILKGAVNTILPLSKIVGEVQYF
>NZ_CP012603.1|WP_001080347.1|2471384_2472467_-|PepSY-domain-containing-protein
MNRKKLYKLHSILGISTGVFLVIVGLSGSLLVFGKEIDQLLNPNLWYISASKERLSIDVLRAKLKQELPSHALAGWLLSEKQNQPDQVWLHFLDSKDRKESIILLNPYTGKILGILSENRSDSFYSWMLKLHYSLLMGSFGYFLTTLFGVIFIFQGFSGMILYRRIWQNLFRLRTRQSLRTFFSDLHKLVGVFSLVFNISLGFTGAWWNVQAIVGLLSAQEERKVEKFFKESISVDSLLKEIKMQLPEFQTGFVSFPHHHEKDPIQFYGTERLTNPFRSRFGSYFRFDSESGKLLEIFNLSNENLFYTIIDSFRPIHYGTFGGIITKILWVILGLSPGILYISGIGILISKRNLQEKRKN
>NZ_CP012603.1|WP_001971044.1|2476036_2477110_-|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_100225741.1|2477181_2477376_+|hypothetical-protein
MRGQLCEVATHGFAVADLDSSMDRGLSPKRAINLPPAFLTPSIQEYHIRNCLTFKKHTNLQIAL
>NZ_CP012603.1|WP_002187457.1|2477707_2479924_-|leucine-rich-repeat-protein
MNFRITLIYLQKITIGLLFLITLSCEIQADEVEPGTYMDLTKALQNPLNVRILDLSGQNFTTLPKEIEQLKNLQELDLGDNQLATFPAVIVELQKLESLDLSENRLVMLPNEIGRLQNLQELGLYKNKLITFPKEIGQLQNLQTLNLQDNQLATLPVEIGRLQNLEKLNLRKNRLTVLPKEIGQLQNLQTLNLQDNQLATLPVEIGQLQNLQTLGLSENQLTTFPKEIGQLENLQELDLNGNQLKTLPKEIGQLQKLEKLNLDGNQITTLPKGNQLTTLPAEIGQLKNLQILSLSYNRLATLPREIGQLQNLKSLDLGGNQLTTLPREINKLKNLKELYLNGNKLTIVPKEIWELENLTILQLKNNRISTLPKEIEKSKNLQELNLRGNRLVTLPGEIGELKLLEELNLENNRIKILPNEIGALENLWIFNLSGNKLASIPKEIGNLQNLRMLYLENNQLKTLPRQMEKLQDLEVLNLLINPLLSEERKKIQALLPNCNIDLRDVEEGGTYRNLNLALEQPLKILSLSLEYQQFSLFPKEILRLKNLRSLSLYDTSLVALPKEIVRLKHLEHLSLGLNQLKSLPKEIGLLRNLRSLDIGANNEFEVLPKEIARLQNLRSLLLNQNRFKIFPKEIWELKKLVILNVNTNQLDALPEKIGRLKGLQMLDLSHNRLTTLPSEIGQLHNLTELYLQYNRIKMLPEEIARLQNLRKLTLYENPIPPQELDKIRKLLPNCEIRF
>NZ_CP012603.1|WP_000915022.1|2480821_2481793_-|membrane-protein
MLKKTSYFSIWQKGFKVSIFLIFYILFPSSVLSQAEENKKNTFELLIKRQTYRWTPYDYTSYTERSILETTIKTDSIKQNQKVLIPLVFRYDQLEKKFRIEVSAYEIELANPNTNVIESGTLGYETRKQYFNPMLRSEAELNYYKILNLYPNWDFFAGAGIRNINKYKYGYFLREGVYEEYFYTYGPQFVFRTEYRFAENWSLSLAADLFYTQGTRFYKPQALTLESMTVSAGTAGAQGIYRGYELDILLGYRVFDSVKFFVGYNYIYSYFSYYSFHQTDIRLQISSLDPFISENSSAPILHMFRSGNHDILQGLYLGMSVSF
>NZ_CP012603.1|WP_002187461.1|2482280_2483861_-|hypothetical-protein
MNFRITLIYLQKITIGLLVLVTLSCEIQAEEVEPGTYRDLTKALQNPLDVRVLNLSGEKLTALPKEIGQLKNLQELNLKWNLLTVLPKEIGQLENLQELDLRDNQLATFPAVIVELQKLESLDLSENRLIILPNEIGRLQNLQDLGLYKNKLTTFPKEIGQLQNLQKLWLSENRLTALPKEIGQLKNLQTLDLQDNQFTTLPKEIGQLQNLQTLNLVNNRLTVFPKEIGQLQNLQDLELLMNPLSLKERKRIQKLFPDSNLDLREVAENGVYRNLNLAQEEPLKVFELSLEYKDFSQSFPKVILKFRNLRGLNLYDCGFSTLPKEISRLKNLKYLALGLNGLKNIPSEIGQLKNLEALNLEANELERLPKEIGQLRNLQKLSLHQNTLKIFPAEIEQLKKLQKLDLSVNQFTTFPKEIGKLENLQTLNLQRNQLTNLTAEIEQLKNLQELDLNDNQFTVLPKEIGKLKKLQTLDLRNNQLTTLPTEIGQLQNLQWLYLQNNQLSLKEQERIRKLLPLKCKIIFEVY
>NZ_CP012603.1|WP_002187452.1|2483931_2485218_-|hypothetical-protein
MNFRITLIYLQKITIGLLFLITLSCEIQADEVKPGTYMDLTKALQNPLNVRVLDLSGQNFTTLPKEIEQLKNLQKLYLFDNRLKTLPKEIGQLKNLQELNLSSNQLTILPKEIGKLENLQRLDLYDNRLTILPIEIGKLQNLQTLYLSSNQLTTLPRESGKLENLQELNLSDNQLTTLPQEIGQLQNLQTLNLKSNQLTTLFKEIEQLKNLQTLNLSDNQLTTLPIEIGKLQNLHTLNLSDNQLAILLIEVGKLQNLHTLNLSDNQLTTLPIEIGKLQNLHTLNLSGNQLTTLPIEIGKLQNLQDLNLHSNQLTTLSKEIEQLKNLQTLSLSYNRLVILPKEIGQLQNLQELNLWNNQLTALPIEIGQLQNLQTLSLYKNRLMTFPKEIGQLKNLQTLYLGGHNQFSSEEKERIRKLLPNCKIYFGDN
>NZ_CP012603.1|WP_025177636.1|2485427_2486273_-|leucine-rich-repeat-domain-containing-protein
MDFTLRSRIKSCGESTMKFRITLIYLQKITIFLLFLIYLSCEIQAEAPEDEPGTYRDLTEALQNSLDVRILILSEQKLTTLPKKIEQLKNLQMLDLCYNQFKTVPKKIEQLKNLQMLDLCYNQFKTVPKKIGQLKNLQVLNLSSNQLTTLPKEIGKLENLQVLNLSSNQLTTLPKEIGKLENLQVLNLGSNRLKTLPKGIEQLKNLQTLYLNYNQLTTLPREIGRLQSLTELHLQHNQIATLPDEIIQLQNLRKLTLYENPIPPQELDKIRKLLPNCEIRF
>NZ_CP012603.1|WP_002187492.1|2486626_2487565_-|tRNA-epoxyqueuosine(34)-reductase-QueG
MIESKEIISEFKTLIEGSGFDLYGICEANIPEEDRENILLWVKEHKHGNMEWYPKNMDLRLDFKNLGFDPQSVIVLGAIYNDPEYEKIRSGMTFQFSKYAVGEDYHRVLRKHAKPLIKALQKKYPNHHFRQGVDSLPVPEKVLARLAGLGWKGKNTNLIHPEIGSFFFITVILTDLPIYTTQVQIKDRCGTCTACIDACPTGALKPYQIDAGKCISHHTLEDGSEEIPDTYGWLVGCDICQDVCPWNRVKAFKKGIRTGLEEFKVRSYLKENPESILTLNEQEFEKKFSDSAISRMNFKMYQRNVNKLKNKI
>NZ_CP012603.1|WP_002187497.1|2487585_2488020_+|hypothetical-protein
MQKELSENSNFTRKDLTIFAKPPISISRSDFITAARLTLSSTNINFATSNPSEQQTLKNNRKFSKQIIFASVLGALKGFEERDLKPFHVNHKPIFTEIGSEILNTEFNPILNEDKIQILKNAFDYGIRKVYHLEWKLYTSKELY

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Crispr_ID: NZ_CP012603_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_3

2748173-2748268

Orphan

Consensus_repeat	Method
AGGAAAGCGTTGTGTTGAGTTTTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012603_3

>merge|NZ_CP012603|3|2748173-2748268|CRISPRCasFinder
AGGAAAGCGTTGTGTTGAGTTTTCCAACGCGACCTGCAGAGCGACCCTTAGGGAGCGATGCATTGAGTTTGAGGAAAGCGTTGTGTTGAGTTTTCC

>NZ_CP012603|3|3|2748173-2748268|CRISPRCasFinder
AGGAAAGCGTTGTGTTGAGTTTTCC	AACGCGACCTGCAGAGCGACCCTTAGGGAGCGATGCATTGAGTTTG
AGGAAAGCGTTGTGTTGAGTTTTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000142583.1\|2738741_2739887_-\|DUF445-family-protein	unknown	unknown	gnl\|CDD\|377281
NZ_CP012603.1\|WP_025176935.1\|2746571_2746874_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|367760
NZ_CP012603.1\|WP_000837198.1\|2749510_2749888_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227933
NZ_CP012603.1\|WP_000127192.1\|2757864_2758746_+\|DUF2225-domain-containing-protein	unknown	unknown	gnl\|CDD\|378340
NZ_CP012603.1\|WP_000492790.1\|2759542_2760361_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000203920.1\|2747206_2747626_+\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366911
NZ_CP012603.1\|WP_001165809.1\|2739883_2742190_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000332802.1\|2743190_2743613_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000601964.1\|2735555_2736677_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|226434
NZ_CP012603.1\|WP_002119423.1\|2744868_2745138_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000568850.1\|2753476_2753977_-\|biotin/lipoyl-binding-protein	unknown	unknown	gnl\|CDD\|133459
NZ_CP012603.1\|WP_001068702.1\|2755433_2756231_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|223282
NZ_CP012603.1\|WP_080010667.1\|2758742_2759540_+\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NZ_CP012603.1\|WP_002105649.1\|2737095_2738205_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|226434
NZ_CP012603.1\|WP_000623976.1\|2753973_2755437_-\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	unknown	unknown	gnl\|CDD\|227111
NZ_CP012603.1\|WP_001970653.1\|2748816_2749350_-\|DUF1493-family-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000825586.1\|2756610_2757720_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002187789.1\|2751060_2752773_-\|peptide-chain-release-factor-3	unknown	unknown	gnl\|CDD\|179105
NZ_CP012603.1\|WP_001983101.1\|2745575_2746487_-\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|240081
NZ_CP012603.1\|WP_001968065.1\|2743722_2744682_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000142583.1\|2738741_2739887_-\|DUF445-family-protein	gnl\|CDD\|377281	pfam04286, DUF445, Protein of unknown function (DUF445). Predicted to be a membrane protein.	7.05074e-12
NZ_CP012603.1\|WP_025176935.1\|2746571_2746874_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	2.09579e-15
NZ_CP012603.1\|WP_000837198.1\|2749510_2749888_-\|hypothetical-protein	gnl\|CDD\|227933	COG5646, COG5646, Uncharacterized conserved protein [Function unknown].	5.30994e-28
NZ_CP012603.1\|WP_000127192.1\|2757864_2758746_+\|DUF2225-domain-containing-protein	gnl\|CDD\|378340	pfam09986, DUF2225, Uncharacterized protein conserved in bacteria (DUF2225). This domain, found in various hypothetical bacterial proteins, has no known function.	6.00995e-67
NZ_CP012603.1\|WP_000203920.1\|2747206_2747626_+\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|366911	pfam02082, Rrf2, Transcriptional regulator. This family is related to pfam001022 and other transcription regulation families (personal obs: Yeats C).	6.79677e-30
NZ_CP012603.1\|WP_000601964.1\|2735555_2736677_-\|histidine-kinase	gnl\|CDD\|226434	COG3920, COG3920, Signal transduction histidine kinase [Signal transduction mechanisms].	3.43923e-49
NZ_CP012603.1\|WP_000568850.1\|2753476_2753977_-\|biotin/lipoyl-binding-protein	gnl\|CDD\|133459	cd06850, biotinyl_domain, The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.	1.99904e-26
NZ_CP012603.1\|WP_001068702.1\|2755433_2756231_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|223282	COG0204, PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism].	1.6769e-09
NZ_CP012603.1\|WP_080010667.1\|2758742_2759540_+\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	2.42801e-95
NZ_CP012603.1\|WP_002105649.1\|2737095_2738205_-\|histidine-kinase	gnl\|CDD\|226434	COG3920, COG3920, Signal transduction histidine kinase [Signal transduction mechanisms].	1.06766e-42
NZ_CP012603.1\|WP_000623976.1\|2753973_2755437_-\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP012603.1\|WP_002187789.1\|2751060_2752773_-\|peptide-chain-release-factor-3	gnl\|CDD\|179105	PRK00741, prfC, peptide chain release factor 3; Provisional.	0
NZ_CP012603.1\|WP_001983101.1\|2745575_2746487_-\|nitronate-monooxygenase	gnl\|CDD\|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	3.78102e-89
NZ_CP012603.1\|WP_001968065.1\|2743722_2744682_-\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	6.09454e-41

>NZ_CP012603.1|WP_000203920.1|2747206_2747626_+|Rrf2-family-transcriptional-regulator
MTSRFTVAIHILSLLSLGEGKTKTSEELAESVNTNPVVIRKILSLLKNQGIVRNQMGPNGGYVLAKTPASINLKEIYEAIDEKIFQMHSKSPNKKCICGHAIQPILSKVYEKAQKVLEEELGSTDLDSITKEILNFSKK
>NZ_CP012603.1|WP_025176935.1|2746571_2746874_+|antibiotic-biosynthesis-monooxygenase
MIVVVSSYKVLEEKIEEFKKASQEMAKESTESEEGVLRLDVLQGDGDPGRFLFMEIYKNETARKQHLESPQFISWRRAVPEWFSQGSTSIQYIPVHIDFK
>NZ_CP012603.1|WP_001983101.1|2745575_2746487_-|nitronate-monooxygenase
MKLNTRITKMLGIDLPIIGAPMFLVSYPDLVVAVSEAGGIGCFPSLNYRSPEQLKDGLQEIRSKTKKPIGVNLILHKSHNPNWSKQLQVVLDAKVELLITSLGSPRTVVNEAKSVGAKVFCDVTTLKHANIVAKAGADALIAVAQGAGGHAGNISPFSLYPYLKKETGLPIVAAGAISSGAQMLAAFSLDADAVYVGTRLIATPEAQASEEYKKMLIDSGPEEIVYTEKISGIPANWLKKSVEKAGDLSHSGQSQNLDQEYKRWRDIWSAGHGVAQIQGLIPAREVVLGMAKEYSDILNRLPR
>NZ_CP012603.1|WP_002119423.1|2744868_2745138_+|hypothetical-protein
MHLILSAVKIGAVLFWIVFGALLFGFISVEFHLSFLIKAVGYGTLVVHLLEIVYFWFLLRNKSNNLFLDCIQILIFGVFHMISLRNKRA
>NZ_CP012603.1|WP_001968065.1|2743722_2744682_-|amidohydrolase
MLPCCHHLLSSNRISNETSPFPWKDPKCLPPLRDDQSPEHIPLMEKYGIPFLIDIHTHFFPEYVMKQIWKWFDGVHWEIAYRETETKRLEILNRNRIFHFTTLNYAHKAKMAEGLNRWVYETHTKTKGAILFGTFFPEEGCLDYTKRAVEEYGFCGFKLHCEVGRLDLTRADLSETFYYLEKKEIPIVIHSGDAPLPGPYTNIRYFKSFIERYPKLKVIVAHMGASEVWEYSELLEIYPELRMDTTMVFVDFLATGENTNSYLEILERYPDRIHFGSDFPNIPYALSHPICNLLNTSLSEEIKRKIFLENSAKLFGISI
>NZ_CP012603.1|WP_000332802.1|2743190_2743613_-|hypothetical-protein
MCDFLKRIFGFILAGFLTIQCGKKNSTQSEETYKRVADAYCTQMNRCKEPYLSSLEGKFRKEAALTYPDNVQCYSDFNYDYDKSEPIVLKKLSDNLKLEAELCIKSVKRADCGSIVTYQIPECAEYNTFLETISIPSLTK
>NZ_CP012603.1|WP_001165809.1|2739883_2742190_-|hypothetical-protein
MQIIQRKWKIPHAARKPLVFFLVFLFLSVQFRFLFSDQVPDSVSLQNQYLIAQDYQILFKNFLSSGYDRSLQGGSPIFYFQAPFFFFLVSFLHTFILFFLPFGVSFNLGILLGLFLFSYAFLKLGFLFLTETNLSPGNTLLTITGLMFYFLYPGDRVVGAGIVGVFQNSISFSVGLAIALLSIYYLEKFRYTGKVSSFFKNLIAGTLVFYTHYETSLFYLIALGIYFLFYKDEFEILEILLIFLVPLLFAFPILWNYFAYISFQQNPPVSFPINGLLSLLGEEFSNSIARPEKILDLIKQILMDQYWIHLLFPILFVIGIRLLFIRKLLPPISRFLIFGALFFYWMATDSSLSMIFPWLHAKWHTALNVSLVFLTLSSLVTARFFLKNLPPGKWKLWSGLILFILGLYRFIVTIPGPATGIETFTDNPSVIWKQKEEWIRVFEKTSYGALIASEEILEEKDFADSRWASVLIRQSVRRNITLKNRFEKSFPASIEEIIRLFPEQGTKTFLNKEEKQINFHPALEREKLSELFSKLLSERGVSYVLLGSDSLNQLAIVSPKYFYKIDQKGKWILWKLNSSRSFMELLPKKPIAILIEDFSLQKLKLESVLDLKFEQNLTLIPVSKEEFKSDQNSFSDVCEVSSCFREKVKEKESFQNKTGTKTDLVGLPTEIWPVTWSDSEIRWEISKEKQSEVCFPTLVHSSFFPLWKLVSGEKVYRTLEDQFYFCSKERKNEFIFYDIRTYLITFVQLLLPLAFLGATFLTRRKVSN
>NZ_CP012603.1|WP_000142583.1|2738741_2739887_-|DUF445-family-protein
MTFFTKDLRKTPFRKRQTLSNSILIGFSAAILFILFLGNPETPIVKIILSALEGGLIGGFCDWFAVWKTYKAIEEDGSKLSTEIGNWVANDLLHHEVIRSRIRMVLEDPSTRNEVHEVLLETFGNEEKTKEVLNGLFSKVEEEIVQYLIHYQFSGTDVALLKELNRQKEIMDTIKLLIGESMIKVADTEEFKSLLQEILGKMNLVAQVVLNLIVDFPKKLKEYGNHVKQGLEIESKDEKTIEKLVSLMAASSETYISSWNELRLDQREKAVRSLMGFLKDQSSRLLAALIQTHLKEIGEVKTLQEYSPLRAVLEFVEKRIDENVSGYIGRQITVRLQSLEPKDLRKNLEWKTRNVLETIRINGSILGFFLGCITGLIRFFF
>NZ_CP012603.1|WP_002105649.1|2737095_2738205_-|histidine-kinase
MVFEKFKRIYAQEPFILRVRALYLLLFNVVVFMFASLSFTFFFNEKEPTYRPSYILFIIASFLSIFLLWIGQFKKALFLTLFSVATGLTWVLLFGNPIGNALWSLSILVILFLLFTDIRTTLYISLFSFILILLFFYRLNLMDKLNSVFVLDSIIGFILFTLLAFLIVNLLNSYIKEKDELIKEIHHRVRNNLQVLSGLAILHNKDDADLQRVLFEFQNRILAMSEVHNYLYKSDNYHSIEFSNVIEKIIENLKSKHKDSKITILNYSEKINLPIEKAIPCAMIFNELLNNSLIHAFKESKNPNIEIHFSKNVSIYKLAVKDNGTGMAIPENWKNSNTIGFTLIQILSRQIHANFEIFNDRGLVAVLEF
>NZ_CP012603.1|WP_000601964.1|2735555_2736677_-|histidine-kinase
MILLKNIILKRFQRIYSQESFILRIRALYLFVFNFVTFAFPGITFCFFFNEVTYRPSFIMLISFSFLSMILVWYGQYQKALILTLFTVVVGITLGLFFGDPDGNALYSFPILVIIFLLFTSIRTTIYISIYSFILIFYFLYVLSQRGTLKTNFAVDSILGFFFFTSIALLTVNLLNSYIKEKDELIKEIHHRVRNNLQVLSGLADLHRNDKSDSQKILFEFQNRILAMSEVHNYLYKSDNYHSIEFSNVIEKIIENLKSKHKDSNVTILNYIEKVDLPIETAIPCAMIFNELLNNSLTHAFKESKDPNIEIHFSKSGENYKLTLKDNGVGMSAPIDLQKSKTTGFTLVYILSKQIRANFKIFNDQGLVTVLEF
>NZ_CP012603.1|WP_001970653.1|2748816_2749350_-|DUF1493-family-protein
MRGIRFVYEFESSKKIDILRISKKIFICIVRHTRKDLDKLSLKTCIVKDLRISGDDVDDLVQDINRYFQIDWSSLNFKEYFGGEGFSIVEFFVFLIRFILNLISNLMKTILRVLINFNFSRFNFFKNNQKDFQIENLIIAAYYGKWDNTLLSHSIPIKKEIQNWQIQYWNRFKRRYY
>NZ_CP012603.1|WP_000837198.1|2749510_2749888_-|hypothetical-protein
MKSKKLNFKNIDEYINNFPKDLQDQLKKLRSTIRKAAPNAEEKISYQMPTFALYGNLVYFAAYKKHIGFYPTSSGIKEFQSELTEYKTSKGAVQFPIDQPLPLKLIAKIVKYRVKENIQTKKSKS
>NZ_CP012603.1|WP_002187789.1|2751060_2752773_-|peptide-chain-release-factor-3
MALNLVGISRSNCPFGLVNDSRFYKKNLEGGRSKTVSDTVEQKSNRTIEEETRRRRTFAIIAHPDAGKTTLTEKLLLYGGAIQLAGAVKARKNRKAATSDWMEMEKEKGISITSAALQFEYSGHVLNLLDTPGHEDFSEDTYRTLIAADTAVMVLDAGKGVEPQTIKLFKVCRDRGIPIVTFINKMDRPTKNLFSLLDEIEKVLGISAVPMVWPIGTGVDFSGVYSRKDKKILTYDKTPGGSQKSTFQTSGVNDPELDSRFEDWVIKTFREELELVEGGISEFSQEDFLDSKITPVFFGSAVNNFGIQLFLDEFIKIAPPPLFFPLKDGSKLDPIQTPFSGFIFKVQANMNRQHRDRIAFLRVTSGKFERGLNVLHGRLGKSVKLSSSFAFFGQDRNTVDEAYPGDIIGLVNPGTYAIGDIVASSKVPDLKSLPVFAPELFATISSSDTSSMKSFRKGIDQLAEEGILHLFSSQTIGGGLPIIGAMGQLQFEVFRRRLLDEYNAPSTITILPYVISCWIGQEDLGKVPSSANLVTDRGGRAALLFDTEWDKGYFQKKNPEITLLDYPPSI
>NZ_CP012603.1|WP_000568850.1|2753476_2753977_-|biotin/lipoyl-binding-protein
MIEENFRFRHREEEIPVRVRSGSPGDVSVSITLGGVVHDFRISRNFQSEGNGLFSGPGNHWRILRKGNQIFIHHKGWNTKVLLSNREIHLEEGSGGLIKSPMPGKVIRVGVSVGTTVKKGSVLAIVEAMKMENNLLSPGDGIVEEVLVKEGNMVSQDDVILKLNLG
>NZ_CP012603.1|WP_000623976.1|2753973_2755437_-|acetyl-CoA-carboxylase-biotin-carboxylase-subunit
MISKLLIANRGEIAVRVIRTCKKLGIKTVAIYSDADRDSPHVKLADESVYVGEPSPASSYLNISNILEAIKKTKTDAVHPGYGFLSEKSEFAKALEKENVLFLGPSPESMELMGDKINSRIKMEASGVPVVPGYNGQNQDPKILQKEAEKIGYPLMIKATAGGGGKGMKRVYKSEEFLFALESAQREAQKAFGDGTVFLEKYVETPRHIEVQVFGDKHGNVMHLFERECSIQRRHQKVIEESPAPNLPISLRDEICRVAVKAAQSIGYVGAGTVEFILGKDSKFYFLEMNTRLQVEHPVTEYITGQDLVEWQIQVAEGKKLSELTKGKTVIQNGHAIEARIYAEDPENNFLPSTGILEYIEFPDREFLRVDTGVETGSEITVYYDPMIAKMIAWGKTREECTARLKESIDSTVIFGPVTNTFYLSGILSHEEFKKGNTHTHFLEEQTILFTPEKEVQADAFSFAAAALSEKKKSQGIWEAVGPGGFW
>NZ_CP012603.1|WP_001068702.1|2755433_2756231_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MNPLKFMESRLGRFPKSYRKIVLKTYLITIVLVFSFAFPSLVAGLFFALIGNQKRKNASFLKGSAVWADAIIWMTKTRFFKIGDFQIPPKGHMIFSNHVNELDFPYDCLVINKPYLANQVIKKTLIAYWWMRAMGSQVFETTKAATIAVSVRNVLKGLDTTSFVVYPEGHNSYREEIQPLQKGMIKLAWENKIPVAIVLKSGLTGYQTLEKGFVVAYKQAGIYDPTQYSSWEEFKDFIFETMDREKKALDSMLSSEVQKESVLVS
>NZ_CP012603.1|WP_000825586.1|2756610_2757720_-|hypothetical-protein
MKRLILISILISILPVSVFGEAVSSKAYKKRVELLLYLRAIEPIVRNYKGEVPGGQNQQNTGATAANNQQTGGAPEQDGDRVKKYKELKRLYQEGLQYFFENNHVNAYRRFLEAQLGTEMLLEELSQFYVERTEEILKSAIEKKNPNNPEDRNLVDIAIEWSKNSFIVRDMTANREAPLTRRMYNPRDFHYVTNKYAIEKNMEMGYKFLGLAKETRNNALKIEKHLEKHQKLQPSHRKHRIEHYIAAIQLCRDARANAINIFKLKYPYDNYYLFKSDAKTEAIKDDEGKAGPSEPVSLNGVTYDFSQNPTLEYDHRMSPVFDRRIPEEYRRDAVDILEKIYDDEVKNRIFLKWDQEKRKQLMGDKAPNK
>NZ_CP012603.1|WP_000127192.1|2757864_2758746_+|DUF2225-domain-containing-protein
MTASALAQGKKISFRAKEDTVCPICNEVHQKENMFQGGGRLIAGKLTIELRRLYEKNKKFGRVSPNDYVISVCPRCLYSSFSKDWSTLDAEEIEKVRSQFDTRRSNLEKILGPLDFYQDRNLVLGAASYLLAIECYQNRKATVAPTPKKAVCSVRGAWYFEDLNNDFPNMGFDKVRDLLYQKAAGWYTETMEIMQSGSEPVDQASYILGPDTDKNWAFDGVIYLSAYLTMKFRDELAPDPAAKLNLLVRAKRTLSRLYGSGKGSKSKPSVIIDMAKELYDEYSKLIEEMGGEK
>NZ_CP012603.1|WP_080010667.1|2758742_2759540_+|tRNA-pseudouridine(38-40)-synthase-TruA
MNYALLVEYDGLCFHGFQTQKGLSSIQENLEKAAKILLKEEIHISGAGRTDTGVHARGMIVNFKTQRVIQNFSKFLLSLNAITDSGLSILNMTEVDENFDSRFSCNSREYEYWILNTKYPRPTWKNRTFWYQHRIDVPRLEAELELLKGEHDFRSLAKVASLKGRSTVRTILDVKLERSLELEGLLKVKIRANGFLHNMIRILTGTLLEISNGKRKDTNVLEILSSKDRTIAGITLPPYGLYFIRAYYDSYPKIDFMYSHLDFLK
>NZ_CP012603.1|WP_000492790.1|2759542_2760361_+|hypothetical-protein
MFSRCRIFLKPTTLIWFAILPGALSASPQKPGTFELLGGYQPNWNRLFTEFLPKRTAQTGNLPSSGVISREEEDIENPEETEEDKQEGYQDNRKTEVGVWVGASNPLPGTETQKYLDTTLGGGFFFRIPWPWIFYLEMGAFYANYLSATERALTTIPVYLALGYKIPLDLPISFILRAGGGEAFVVARPSNTSRWDPMMIVGLETSFVAGKKIRIGIRIDYNKIYESRMDAPRETKYPYTSPYEDSRLSNPNYYRVVDTEFFQFGLMVSVFL

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Crispr_ID: NZ_CP012603_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_4

2764198-2764364

Orphan

Consensus_repeat	Method
TCCCATTTTAATTCATTATGTTTTTTGAAAGTTTTTCAATTATTAAAAAATTGTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012603_4

>merge|NZ_CP012603|4|2764198-2764364|CRISPRCasFinder
TCCCATTTTAATTCATTATGTTTTTTGAAAGTTTTTCAATTATTAAAAAATTGTATTAGTTTTCAGAATTTCACTGTAAAACTACAGCTTGAAAGAGTTCCCACAAATTACGTCCCATTTTAATTCATTATGTTTTTTGAAAGTTTTTCAATTATTAAAAAATTGTA

>NZ_CP012603|4|4|2764198-2764364|CRISPRCasFinder
TCCCATTTTAATTCATTATGTTTTTTGAAAGTTTTTCAATTATTAAAAAATTGTA	TTAGTTTTCAGAATTTCACTGTAAAACTACAGCTTGAAAGAGTTCCCACAAATTACG
TCCCATTTTAATTCATTATGTTTTTTGAAAGTTTTTCAATTATTAAAAAATTGTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000599731.1\|2775775_2776288_-\|rod-shape-determining-protein-MreD	unknown	unknown	gnl\|CDD\|274574
NZ_CP012603.1\|WP_002187841.1\|2771120_2771903_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000465997.1\|2768926_2769337_-\|6-carboxytetrahydropterin-synthase	unknown	unknown	gnl\|CDD\|376501
NZ_CP012603.1\|WP_001971044.1\|2762459_2763533_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000492790.1\|2759542_2760361_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000900432.1\|2773830_2775774_-\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NZ_CP012603.1\|WP_000693594.1\|2766804_2767809_+\|sulfate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224529
NZ_CP012603.1\|WP_000739010.1\|2764946_2766776_+\|alginate-export-family-protein	unknown	unknown	gnl\|CDD\|372583
NZ_CP012603.1\|WP_000141324.1\|2769464_2769692_+\|DUF1858-domain-containing-protein	unknown	unknown	gnl\|CDD\|274898
NZ_CP012603.1\|WP_000964329.1\|2776284_2777382_-\|rod-shape-determining-protein-MreC	unknown	unknown	gnl\|CDD\|237560
NZ_CP012603.1\|WP_000568850.1\|2753476_2753977_-\|biotin/lipoyl-binding-protein	unknown	unknown	gnl\|CDD\|133459
NZ_CP012603.1\|WP_001068702.1\|2755433_2756231_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|223282
NZ_CP012603.1\|WP_080010667.1\|2758742_2759540_+\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NZ_CP012603.1\|WP_000801434.1\|2772338_2773844_-\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NZ_CP012603.1\|WP_000831279.1\|2760357_2761647_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000672053.1\|2769990_2770734_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000623976.1\|2753973_2755437_-\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	unknown	unknown	gnl\|CDD\|227111
NZ_CP012603.1\|WP_000825586.1\|2756610_2757720_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_100225746.1\|2763604_2763847_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000127192.1\|2757864_2758746_+\|DUF2225-domain-containing-protein	unknown	unknown	gnl\|CDD\|378340

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000599731.1\|2775775_2776288_-\|rod-shape-determining-protein-MreD	gnl\|CDD\|274574	TIGR03426, shape_MreD, rod shape-determining protein MreD. Members of this protein family are the MreD protein of bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. It is highly hydrophobic (therefore somewhat low-complexity) and highly divergent, and therefore sometimes tricky to discover by homology, but this model finds most examples. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	6.58697e-07
NZ_CP012603.1\|WP_000465997.1\|2768926_2769337_-\|6-carboxytetrahydropterin-synthase	gnl\|CDD\|376501	pfam01242, PTPS, 6-pyruvoyl tetrahydropterin synthase. 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.	7.99295e-37
NZ_CP012603.1\|WP_000127192.1\|2757864_2758746_+\|DUF2225-domain-containing-protein	gnl\|CDD\|378340	pfam09986, DUF2225, Uncharacterized protein conserved in bacteria (DUF2225). This domain, found in various hypothetical bacterial proteins, has no known function.	6.00995e-67
NZ_CP012603.1\|WP_001971044.1\|2762459_2763533_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27
NZ_CP012603.1\|WP_000900432.1\|2773830_2775774_-\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP012603.1\|WP_000693594.1\|2766804_2767809_+\|sulfate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224529	COG1613, Sbp, ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism].	0
NZ_CP012603.1\|WP_000739010.1\|2764946_2766776_+\|alginate-export-family-protein	gnl\|CDD\|372583	pfam13372, Alginate_exp, Alginate export. This domain forms an 18-stranded beta-barrel pore which is likely to act as an alginate export channel.	1.64429e-18
NZ_CP012603.1\|WP_000141324.1\|2769464_2769692_+\|DUF1858-domain-containing-protein	gnl\|CDD\|274898	TIGR03980, conserved_hypothetical_protein, hybrid cluster protein-associated redox disulfide domain. Members of this protein family resemble the domain of unknown function DUF1858 described by pfam08984, but all members contain an apparent redox-active disulfide. In at least one member protein, a cysteine in the CXXC motif is substituted by a selenocysteine. Most member proteins consist of this domain only, but a few members are fused to or adjacent to members of the hybrid-cluster (prismane) family or the nitrite/sulfite reductase family. [Energy metabolism, Electron transport].	1.06335e-17
NZ_CP012603.1\|WP_000964329.1\|2776284_2777382_-\|rod-shape-determining-protein-MreC	gnl\|CDD\|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	4.05585e-52
NZ_CP012603.1\|WP_000568850.1\|2753476_2753977_-\|biotin/lipoyl-binding-protein	gnl\|CDD\|133459	cd06850, biotinyl_domain, The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.	1.99904e-26
NZ_CP012603.1\|WP_001068702.1\|2755433_2756231_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|223282	COG0204, PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism].	1.6769e-09
NZ_CP012603.1\|WP_080010667.1\|2758742_2759540_+\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	2.42801e-95
NZ_CP012603.1\|WP_000801434.1\|2772338_2773844_-\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	5.93069e-65
NZ_CP012603.1\|WP_000623976.1\|2753973_2755437_-\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0

>NZ_CP012603.1|WP_100225746.1|2763604_2763847_+|hypothetical-protein
MRGQLCEVATHGFAVADLDSSMDRGLSPKRAINLPPAFLTPSIQEYHIRNCLTFKKHTNLWIAFYIETKDDYYIMFSVCN
>NZ_CP012603.1|WP_001971044.1|2762459_2763533_-|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_000831279.1|2760357_2761647_+|hypothetical-protein
MKRSYLRFFLILSCFLMFFCKVGDWHGKHSKNPVISTLFNQRMLLLVKGTYATDNPIGFEAYSGGTGQLYQDTSGEGADPAFGLDGVPLAQNLPIFIDIGEIRLSTKYQEGAFDLSLVKNVKDTKSLWDEIAPNRQVFCTIPYTTNSNSCRLNDGEFKAIQFFNGEGVAYPSNDPTSATDWGAFGNGPVQFYYTGLYLRSLVTAWATEPGLTFSNLTLFDNYRVPGINIVPRLSYKPGADATTKSVFPPLVFPVLYKAEKGDQDMLIYPGFDPYILEVRINLKENLMIHSYVSSIGGVRTLVGISDWKPDSDHKGESDMGGGLLVRSRIIRPEKASSLTVLGGTTSTTHYYSVYRLSESEIDTKLPLMASPVQGVSTKMKYIHSGDYRLRCMGDLAKVDGYPETVVRETVFTVPENAPHSEVQVNLTCP
>NZ_CP012603.1|WP_000492790.1|2759542_2760361_+|hypothetical-protein
MFSRCRIFLKPTTLIWFAILPGALSASPQKPGTFELLGGYQPNWNRLFTEFLPKRTAQTGNLPSSGVISREEEDIENPEETEEDKQEGYQDNRKTEVGVWVGASNPLPGTETQKYLDTTLGGGFFFRIPWPWIFYLEMGAFYANYLSATERALTTIPVYLALGYKIPLDLPISFILRAGGGEAFVVARPSNTSRWDPMMIVGLETSFVAGKKIRIGIRIDYNKIYESRMDAPRETKYPYTSPYEDSRLSNPNYYRVVDTEFFQFGLMVSVFL
>NZ_CP012603.1|WP_080010667.1|2758742_2759540_+|tRNA-pseudouridine(38-40)-synthase-TruA
MNYALLVEYDGLCFHGFQTQKGLSSIQENLEKAAKILLKEEIHISGAGRTDTGVHARGMIVNFKTQRVIQNFSKFLLSLNAITDSGLSILNMTEVDENFDSRFSCNSREYEYWILNTKYPRPTWKNRTFWYQHRIDVPRLEAELELLKGEHDFRSLAKVASLKGRSTVRTILDVKLERSLELEGLLKVKIRANGFLHNMIRILTGTLLEISNGKRKDTNVLEILSSKDRTIAGITLPPYGLYFIRAYYDSYPKIDFMYSHLDFLK
>NZ_CP012603.1|WP_000127192.1|2757864_2758746_+|DUF2225-domain-containing-protein
MTASALAQGKKISFRAKEDTVCPICNEVHQKENMFQGGGRLIAGKLTIELRRLYEKNKKFGRVSPNDYVISVCPRCLYSSFSKDWSTLDAEEIEKVRSQFDTRRSNLEKILGPLDFYQDRNLVLGAASYLLAIECYQNRKATVAPTPKKAVCSVRGAWYFEDLNNDFPNMGFDKVRDLLYQKAAGWYTETMEIMQSGSEPVDQASYILGPDTDKNWAFDGVIYLSAYLTMKFRDELAPDPAAKLNLLVRAKRTLSRLYGSGKGSKSKPSVIIDMAKELYDEYSKLIEEMGGEK
>NZ_CP012603.1|WP_000825586.1|2756610_2757720_-|hypothetical-protein
MKRLILISILISILPVSVFGEAVSSKAYKKRVELLLYLRAIEPIVRNYKGEVPGGQNQQNTGATAANNQQTGGAPEQDGDRVKKYKELKRLYQEGLQYFFENNHVNAYRRFLEAQLGTEMLLEELSQFYVERTEEILKSAIEKKNPNNPEDRNLVDIAIEWSKNSFIVRDMTANREAPLTRRMYNPRDFHYVTNKYAIEKNMEMGYKFLGLAKETRNNALKIEKHLEKHQKLQPSHRKHRIEHYIAAIQLCRDARANAINIFKLKYPYDNYYLFKSDAKTEAIKDDEGKAGPSEPVSLNGVTYDFSQNPTLEYDHRMSPVFDRRIPEEYRRDAVDILEKIYDDEVKNRIFLKWDQEKRKQLMGDKAPNK
>NZ_CP012603.1|WP_001068702.1|2755433_2756231_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MNPLKFMESRLGRFPKSYRKIVLKTYLITIVLVFSFAFPSLVAGLFFALIGNQKRKNASFLKGSAVWADAIIWMTKTRFFKIGDFQIPPKGHMIFSNHVNELDFPYDCLVINKPYLANQVIKKTLIAYWWMRAMGSQVFETTKAATIAVSVRNVLKGLDTTSFVVYPEGHNSYREEIQPLQKGMIKLAWENKIPVAIVLKSGLTGYQTLEKGFVVAYKQAGIYDPTQYSSWEEFKDFIFETMDREKKALDSMLSSEVQKESVLVS
>NZ_CP012603.1|WP_000623976.1|2753973_2755437_-|acetyl-CoA-carboxylase-biotin-carboxylase-subunit
MISKLLIANRGEIAVRVIRTCKKLGIKTVAIYSDADRDSPHVKLADESVYVGEPSPASSYLNISNILEAIKKTKTDAVHPGYGFLSEKSEFAKALEKENVLFLGPSPESMELMGDKINSRIKMEASGVPVVPGYNGQNQDPKILQKEAEKIGYPLMIKATAGGGGKGMKRVYKSEEFLFALESAQREAQKAFGDGTVFLEKYVETPRHIEVQVFGDKHGNVMHLFERECSIQRRHQKVIEESPAPNLPISLRDEICRVAVKAAQSIGYVGAGTVEFILGKDSKFYFLEMNTRLQVEHPVTEYITGQDLVEWQIQVAEGKKLSELTKGKTVIQNGHAIEARIYAEDPENNFLPSTGILEYIEFPDREFLRVDTGVETGSEITVYYDPMIAKMIAWGKTREECTARLKESIDSTVIFGPVTNTFYLSGILSHEEFKKGNTHTHFLEEQTILFTPEKEVQADAFSFAAAALSEKKKSQGIWEAVGPGGFW
>NZ_CP012603.1|WP_000568850.1|2753476_2753977_-|biotin/lipoyl-binding-protein
MIEENFRFRHREEEIPVRVRSGSPGDVSVSITLGGVVHDFRISRNFQSEGNGLFSGPGNHWRILRKGNQIFIHHKGWNTKVLLSNREIHLEEGSGGLIKSPMPGKVIRVGVSVGTTVKKGSVLAIVEAMKMENNLLSPGDGIVEEVLVKEGNMVSQDDVILKLNLG
>NZ_CP012603.1|WP_000739010.1|2764946_2766776_+|alginate-export-family-protein
MKKNAIFKVSAGALLFCCIIPLNLFSQNSKKEKTNGPVLNLDPPSDVRYEEQPNDGKGIPEIQEELAKEEPYKSPYKGKLPGEFMKSMLLSPEHQEAIRRTDKLWFGDIFRTGFQIRPRFDYSHNADFDKRTQDDRNYATQNSQVFFVVDPNPYVAAKVTIQDVRVFGGEQSRKDGQLGYLGLSNSAGIELSSAPTANNSVSIKNNTDLREGFVQLKNFADGFEIFIGRQIFGFGDNRYVGGRNDGQTGNSFDGARVKYNSKYFNSEAFTSIIAEDSNAGAGNNTANGVKRGTVNDTYLSGLYNTVKFEDFNVDLYYFNVDRKWEQGPNPATSQDRTRQRDDLNTVGFRLTNRTDNNRLPKTKAWDWTLEASWQYGYNGQRVNAGWDTLKQTVDGNPNSKRIYTERVEYDSKFFIAQTGYTFFDRFRVGIQYSIGSGDPNRTDNKVATYDASFATRSGGFPYFDSGNGIANATFWSNTRTKSIHLMYNSPNYGRFIFVVYDIQKASVNDAWYSSGGAANTGLTTENPTGAAFGGYKLGEKGGKRLFYEFDLIYQFYLKDYVSIWTGGSYLLAGDAVRNARVNPWAPNINDRYTLDNRAYSFFLFVQFAM
>NZ_CP012603.1|WP_000693594.1|2766804_2767809_+|sulfate-ABC-transporter-substrate-binding-protein
MKIKFFKITTIVFFTMTSNLGLFAKDITLLNVSYDPTRELYAEYNKLFASYWKSKTGDEVRVNQSHGGSGKQARSVIDGLEADIVTLALAYDIDIIASKGLISRDWLKSLPNNSTPYTSTIVFVVRKGNPKNIKDWDDLVKSKISVITPNPKTSGGARWNYLAAWAFAQKKFNNDTNKVQDFIKTLYKNVPVLDSGARGSSNTFAQNGIGDVLIAWENESFLILEEFGKDKYEVVIPSLSILAEPPVAIVEKNADKHGNLETAKAYLKSLYSEAAQEIIAKHGYRPRSQTILKKYETKFPKLDLITVDGHFNGWQKAHKDHFADGASFDQLYVK
>NZ_CP012603.1|WP_000465997.1|2768926_2769337_-|6-carboxytetrahydropterin-synthase
MFFQESGRFYIRIEERFESSHYLYKYFPDGSDEPIHGHSWKVELYLSGKKNIGDDGISFDFLTSKQKLKELVGRLDHILINDLEEFKKINPTSENIARWFYHYLKESVHTAGGKVDRIVIHEGPENLAFFEPTSLS
>NZ_CP012603.1|WP_000141324.1|2769464_2769692_+|DUF1858-domain-containing-protein
MTEVVKPRFYKEMTVGEAMAVHPEAGLVFSSYHLGGCSHCSINELETIEQVCMGYGVEVDVLVESLNNLLEDSED
>NZ_CP012603.1|WP_000672053.1|2769990_2770734_+|hypothetical-protein
MKFRFQKLGSIFVCIFYNLFFSFVSLEAITIEVFIPLCDGKSLVCGKGKAGDPRSLEENLYWGAAFGAETFFKRNSNFKILEIKERKLDSPILRTLIIEKKRKQNETYTKLIIYAYAGDKIDNALLDFLNASSGKSLADIIVWSGHNRLMDRISPKLQSQSAKTVAVLACESEKYFDSVLRSIGAKPIVLTKTFMAPEAYLLEALTETVSKFGAEDKKSIRSAMIRSYAKYQKISLKAAGSVFSKLE
>NZ_CP012603.1|WP_002187841.1|2771120_2771903_-|hypothetical-protein
MDPVKDSRFFFDLKRKFEVILEEVEKKTFDQKDEIRELESLWEEMFELAGKNDSPYFQIRLKNLKKQLETFVKNKGYEKQEFDRIYHQLGKMKQNDSVEFLDESLRNRLERIAQKHYSPGDMTSSEVVATSKKGKYYITFRCGTIYFITDWSSYTVLKDLDRRKNTVEYKGSVYRIFPSAFVYGLSEEEYRNENFLTMNLLVLKRESGLEFYRFDTLGEILQINEGTFLKGLKPIESSEIDKRIRNYFRKAGIRYYYIPV
>NZ_CP012603.1|WP_000801434.1|2772338_2773844_-|rod-shape-determining-protein-RodA
MKPDKSIEKIDYFLVISVVIVVLCSVTTLYSQEVNFEDGPGKWYRQLFYFIIGLAIMYFVSRVNYQLLGAYALVIYVFTVFLLMITLIPGIGYLPSGRGARSWIKLGPVGIQASEFAKLSTVILLGQFMVLKEKDMRNLVVLSIPFIIVIVPMIFILLQPDFGTAVSFLPILFTMLFLGGADILHIGSLLAFGGITLMVPMFVEYSKLTLINDISDFLQRTGKTDLLSVVNRLGGKIWLALDGKDVKAANLTPKTLNALQEVVDQVVEVEGGFFFKIFSNQKLLLTFGALFLIASIVMVGIRIARGSKTLRQYYIPLGILGISLISAVVVMKTVPFRENQVIRLTAFLNPEEFKQGAGYHLRASKPAVGSGRFFGKGLMNAEMTEGRIPHVPESSTDFIFASWAEQTGFLGSVFLLFFLFSIPLRGLQISYESKDRFGSLLASGIVALLFYHMAINIGIVIGLMPVTGIPLSFMSYGGSHLVMSMTAVGIILSIKSRKHAN
>NZ_CP012603.1|WP_000900432.1|2773830_2775774_-|penicillin-binding-protein-2
MLGGAQSASEYRLEKSFRLRLYTFSGLVVFALAAFIFQLFNLQILNGTDNALKAEKFVRKSEIMPAARGQMFDRNFLTPETSMALVSNYSSLDVVLNTSLFKYDPTSVKAFIQEFARTLSIPISYYQDELIEPRFSRNLKAKKPIVLLEGISTAQQERISVFDNISKYIVLLPSPRRVYKMGPALAHVTGYIGKPTRDDLVSGKIKSYQYLGKDGLELEYDSELRGVDGFRIQKRSSEGNIEEERVVEHSSPGNNLVLTIDKDIQIAAYKALKGSRGTAIAIKVATGEILAMVSNPSYDPNILSGKNRADRTAHFKRVKDNGGFLNLAIKSKFPPASTYKTLVALAALESQHKIGYTPETTFSCNGSFVLKSTFAGVPDQVFLCWEKGGHGTNDLAHALQKSCSVYFYNLGYKLGSDAILNYSRLFGLENKSKVDLPDETAGFVPSSAWKKRTYGTKWFDGDTINLSIGQGFISTTPIGMALFYMGLLNRGQIYQPYVVSEIRDPVDNSIINRTTPQILRDIPINQSSVEAIKEGLKLVVKSGTAAHVLNKPFLPEIAGKTGTAQTRRRGASGSNHAWFVGYAPANAPASEQVLVVVFVEYGIGGAAGAAPVAREMFHAAFPPGTFKKTQEVNPQPKIGQEGTLEAR
>NZ_CP012603.1|WP_000599731.1|2775775_2776288_-|rod-shape-determining-protein-MreD
MILEKLVIAIGILIAHFLNGSNLFEIGSAIKPDFMILLVLFFALRRGPLYGLWIGFFGGLLTDSGLGGEISVGNVVTYKIGLHSLTFCLIGYLVGKFARSAYHENYLSITIYSLLITFITRLATYYLFSLFFHENMSYSLFFTSLFNALIAPAFFYALTWIYQLDHMGDA
>NZ_CP012603.1|WP_000964329.1|2776284_2777382_-|rod-shape-determining-protein-MreC
MLWFQLSRSKETLSLLFCILFSILSLTFRSNVIVRGIASFQRVGDVVSGSIDSFGGFFKGAYNKLESFETIRKERDSCVAVMEDYKLLPQDLEKANRENDALRKELKFHSRQKYSSLKAEVLSVRLNSIYRTIIIDKGSDSGIKPYMPVTARAVDQKGAIIEALVGKVIAVTGGSAVVQPLINSNFNMGISMPDTNLWANLSGNSGRGTEALLNYIDSGIIIDPRVFGEYPMGPSEMIQYTESLSKIGKPVYTSGGGGVFPSGIPVGIITEEGPRNGSFKSAYLKPFVRFEMLESVTILLKLPEKWLETWPEGQNITIENPYFGELNFPGEDRLKENQTKTPNTNQTQTNETKNQPSTPNEEDLQ

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Crispr_ID: NZ_CP012603_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_6

3285950-3286130

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

2 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP012603_6

>merge|NZ_CP012603|6|3285950-3286130|CRISPRCasFinder
ACTTACAAAAATCGGGTGCCGGTAGGCGTTGAGCACTTGGTTCTTTTGTATATTTAAAACGACTTACAGTTTCTGAATATAACTTTGATGCCATTAGGCGTTGAGCACATTTCTGCATCCTCTTTTTCGTTCAGTTTCCACAGCCTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

>NZ_CP012603|6|6|3285950-3286130|CRISPRCasFinder
ACTTACAAAAATCGGGTGCCGGTAGGCGTTGAGCAC	TTGGTTCTTTTGTATATTTAAAACGACTTACAGTTT
CTGAATATAACTTTGATGCCATTAGGCGTTGAGCAC	ATTTCTGCATCCTCTTTTTCGTTCAGTTTCCACAGC
CTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP012603.1\|WP_000110275.1\|3284718_3284922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP012603.1\|WP_001072139.1\|3279548_3279935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000451411.1\|3280118_3280331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP012603.1\|WP_002188754.1\|3300886_3301069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP012603.1\|WP_050561984.1\|3276551_3276761_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_157787513.1\|3297516_3297702_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP012603.1\|WP_001110347.1\|3278654_3279206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.4159e-28
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP012603.1|WP_000110275.1|3284718_3284922_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP012603.1|WP_000683530.1|3284313_3284598_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP012603.1|WP_060684644.1|3282688_3284314_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVDLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP012603.1|WP_080010676.1|3282000_3282210_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP012603.1|WP_000578381.1|3280592_3281468_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP012603.1|WP_000451411.1|3280118_3280331_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP012603.1|WP_001072139.1|3279548_3279935_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP012603.1|WP_001110347.1|3278654_3279206_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP012603.1|WP_001971044.1|3276973_3278047_+|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_050561984.1|3276551_3276761_-|hypothetical-protein
MRNCLTFKKHTNLWIAFYIETKDKISHYISFMQLIDQDRELGPATPNLPLELLKNEFSISVLWKRLIEY
>NZ_CP012603.1|WP_001216977.1|3289628_3290024_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP012603.1|WP_000026902.1|3290304_3290937_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP012603.1|WP_000601700.1|3290933_3293192_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP012603.1|WP_000098750.1|3293193_3295077_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP012603.1|WP_002188755.1|3295141_3295981_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP012603.1|WP_000371343.1|3296001_3296625_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP012603.1|WP_157787513.1|3297516_3297702_-|hypothetical-protein
MRWPIWIHLRNGVLQSPKRAINLPPAFLTPSIQEYHTSTCLTSKNHTNLRIALENSTQRSL
>NZ_CP012603.1|WP_002164578.1|3299090_3300164_+|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP012603.1|WP_001140542.1|3300465_3300894_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP012603.1|WP_002188754.1|3300886_3301069_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP012603_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_5

3284965-3285794

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	PILER-CR
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRT

11 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP012603_5

>merge|NZ_CP012603|5|3284965-3285794|PILER-CR,CRISPRCasFinder,CRT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACCCAGCGGGATTCTTGGAAATAAATTACTCAACAAACTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTTAAATCGGAAGCATGTTGCGACTCGATTTCGAAATCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACCAAATATTCATGGCGCCTTGTCTCCCTGGGCTTCACACTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTTTTGGACAACAACTTCCTCGCTCCCCGCATGTTCTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTAACAACATAGTCTTTAGAGATAGAGGCCATGACAAGCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACACATACTAATTTTTGATCCAACTGTTGTTGTGTTAATCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACACAAAAAAAGACAAGTTGGTCCGGAATGCGTTTGGCCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACCTAGAGTGGCGTGAATTTTTGCATGAGTTGACCCTTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTATCGTTATCCGCCAAGGCGTTATCAGTTCTACAATCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACTTAACAACCATATCTGTAGTCTTATATGCAATTTTCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACATCGGAATATTTGCCCCTTTTGTATCATAGTCGTAACTGAATATAACTTTGATGCCGTTAGGCGATTTAGACG

>NZ_CP012603|5|1|3284965-3285721|PILER-CR
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CCAGCGGGATTCTTGGAAATAAATTACTCAACAAA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTAAATCGGAAGCATGTTGCGACTCGATTTCGAAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CAAATATTCATGGCGCCTTGTCTCCCTGGGCTTCACA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTTTGGACAACAACTTCCTCGCTCCCCGCATGTTCT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TAACAACATAGTCTTTAGAGATAGAGGCCATGACAAG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACATACTAATTTTTGATCCAACTGTTGTTGTGTTAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACAAAAAAAGACAAGTTGGTCCGGAATGCGTTTGGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CTAGAGTGGCGTGAATTTTTGCATGAGTTGACCCTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TATCGTTATCCGCCAAGGCGTTATCAGTTCTACAAT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTAACAACCATATCTGTAGTCTTATATGCAATTTT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC

>NZ_CP012603|5|5|3284965-3285794|CRISPRCasFinder
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CCAGCGGGATTCTTGGAAATAAATTACTCAACAAA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTAAATCGGAAGCATGTTGCGACTCGATTTCGAAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CAAATATTCATGGCGCCTTGTCTCCCTGGGCTTCACA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTTTGGACAACAACTTCCTCGCTCCCCGCATGTTCT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TAACAACATAGTCTTTAGAGATAGAGGCCATGACAAG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACATACTAATTTTTGATCCAACTGTTGTTGTGTTAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACAAAAAAAGACAAGTTGGTCCGGAATGCGTTTGGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CTAGAGTGGCGTGAATTTTTGCATGAGTTGACCCTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TATCGTTATCCGCCAAGGCGTTATCAGTTCTACAAT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTAACAACCATATCTGTAGTCTTATATGCAATTTT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	ATCGGAATATTTGCCCCTTTTGTATCATAGTCGTAA
CTGAATATAACTTTGATGCCGTTAGGCGATTTAGACG

>NZ_CP012603|5|1|3284965-3285793|CRT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CCAGCGGGATTCTTGGAAATAAATTACTCAACAAA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTAAATCGGAAGCATGTTGCGACTCGATTTCGAAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CAAATATTCATGGCGCCTTGTCTCCCTGGGCTTCACA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTTTGGACAACAACTTCCTCGCTCCCCGCATGTTCT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TAACAACATAGTCTTTAGAGATAGAGGCCATGACAAG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACATACTAATTTTTGATCCAACTGTTGTTGTGTTAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACAAAAAAAGACAAGTTGGTCCGGAATGCGTTTGGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CTAGAGTGGCGTGAATTTTTGCATGAGTTGACCCTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TATCGTTATCCGCCAAGGCGTTATCAGTTCTACAAT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTAACAACCATATCTGTAGTCTTATATGCAATTTT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	ATCGGAATATTTGCCCCTTTTGTATCATAGTCGTAA
CTGAATATAACTTTGATGCCGTTAGGCGATTTAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP012603.1\|WP_000110275.1\|3284718_3284922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP012603.1\|WP_001072139.1\|3279548_3279935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000451411.1\|3280118_3280331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188749.1\|3285809_3286043_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP012603.1\|WP_050561984.1\|3276551_3276761_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_157787513.1\|3297516_3297702_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP012603.1\|WP_001110347.1\|3278654_3279206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.4159e-28
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP012603.1|WP_000110275.1|3284718_3284922_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP012603.1|WP_000683530.1|3284313_3284598_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP012603.1|WP_060684644.1|3282688_3284314_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVDLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP012603.1|WP_080010676.1|3282000_3282210_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP012603.1|WP_000578381.1|3280592_3281468_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP012603.1|WP_000451411.1|3280118_3280331_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP012603.1|WP_001072139.1|3279548_3279935_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP012603.1|WP_001110347.1|3278654_3279206_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP012603.1|WP_001971044.1|3276973_3278047_+|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_050561984.1|3276551_3276761_-|hypothetical-protein
MRNCLTFKKHTNLWIAFYIETKDKISHYISFMQLIDQDRELGPATPNLPLELLKNEFSISVLWKRLIEY
>NZ_CP012603.1|WP_002188749.1|3285809_3286043_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP012603.1|WP_001216977.1|3289628_3290024_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP012603.1|WP_000026902.1|3290304_3290937_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP012603.1|WP_000601700.1|3290933_3293192_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP012603.1|WP_000098750.1|3293193_3295077_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP012603.1|WP_002188755.1|3295141_3295981_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP012603.1|WP_000371343.1|3296001_3296625_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP012603.1|WP_157787513.1|3297516_3297702_-|hypothetical-protein
MRWPIWIHLRNGVLQSPKRAINLPPAFLTPSIQEYHTSTCLTSKNHTNLRIALENSTQRSL
>NZ_CP012603.1|WP_002164578.1|3299090_3300164_+|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP012603.1|WP_001140542.1|3300465_3300894_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI

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Crispr_ID: NZ_CP012603_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_7

3286288-3286395

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP012603_7

>merge|NZ_CP012603|7|3286288-3286395|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACCAACGTTTCGCGGGACCTTGATTCCTTCGGAGCGACTGAATATAACTTTGATGCCGGTAGGCGATTTAGATG

>NZ_CP012603|7|7|3286288-3286395|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	CAACGTTTCGCGGGACCTTGATTCCTTCGGAGCGA
CTGAATATAACTTTGATGCCGGTAGGCGATTTAGATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP012603.1\|WP_000110275.1\|3284718_3284922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP012603.1\|WP_001072139.1\|3279548_3279935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000451411.1\|3280118_3280331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188749.1\|3285809_3286043_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188754.1\|3300886_3301069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP012603.1\|WP_157787513.1\|3297516_3297702_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP012603.1\|WP_001110347.1\|3278654_3279206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.4159e-28
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP012603.1|WP_002188749.1|3285809_3286043_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP012603.1|WP_000110275.1|3284718_3284922_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP012603.1|WP_000683530.1|3284313_3284598_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP012603.1|WP_060684644.1|3282688_3284314_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVDLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP012603.1|WP_080010676.1|3282000_3282210_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP012603.1|WP_000578381.1|3280592_3281468_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP012603.1|WP_000451411.1|3280118_3280331_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP012603.1|WP_001072139.1|3279548_3279935_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP012603.1|WP_001110347.1|3278654_3279206_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP012603.1|WP_001971044.1|3276973_3278047_+|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_001216977.1|3289628_3290024_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP012603.1|WP_000026902.1|3290304_3290937_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP012603.1|WP_000601700.1|3290933_3293192_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP012603.1|WP_000098750.1|3293193_3295077_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP012603.1|WP_002188755.1|3295141_3295981_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP012603.1|WP_000371343.1|3296001_3296625_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP012603.1|WP_157787513.1|3297516_3297702_-|hypothetical-protein
MRWPIWIHLRNGVLQSPKRAINLPPAFLTPSIQEYHTSTCLTSKNHTNLRIALENSTQRSL
>NZ_CP012603.1|WP_002164578.1|3299090_3300164_+|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP012603.1|WP_001140542.1|3300465_3300894_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP012603.1|WP_002188754.1|3300886_3301069_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP012603_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_8

3286550-3286657

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP012603_8

>merge|NZ_CP012603|8|3286550-3286657|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACAGCGTTTCTAATTTTTCGTCTACAGTCACTTTACGCTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

>NZ_CP012603|8|8|3286550-3286657|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	AGCGTTTCTAATTTTTCGTCTACAGTCACTTTACG
CTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP012603.1\|WP_000110275.1\|3284718_3284922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP012603.1\|WP_001072139.1\|3279548_3279935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000451411.1\|3280118_3280331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188749.1\|3285809_3286043_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188754.1\|3300886_3301069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP012603.1\|WP_157787513.1\|3297516_3297702_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP012603.1\|WP_001110347.1\|3278654_3279206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.4159e-28
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP012603.1|WP_002188749.1|3285809_3286043_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP012603.1|WP_000110275.1|3284718_3284922_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP012603.1|WP_000683530.1|3284313_3284598_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP012603.1|WP_060684644.1|3282688_3284314_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVDLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP012603.1|WP_080010676.1|3282000_3282210_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP012603.1|WP_000578381.1|3280592_3281468_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP012603.1|WP_000451411.1|3280118_3280331_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP012603.1|WP_001072139.1|3279548_3279935_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP012603.1|WP_001110347.1|3278654_3279206_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP012603.1|WP_001971044.1|3276973_3278047_+|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_001216977.1|3289628_3290024_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP012603.1|WP_000026902.1|3290304_3290937_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP012603.1|WP_000601700.1|3290933_3293192_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP012603.1|WP_000098750.1|3293193_3295077_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP012603.1|WP_002188755.1|3295141_3295981_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP012603.1|WP_000371343.1|3296001_3296625_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP012603.1|WP_157787513.1|3297516_3297702_-|hypothetical-protein
MRWPIWIHLRNGVLQSPKRAINLPPAFLTPSIQEYHTSTCLTSKNHTNLRIALENSTQRSL
>NZ_CP012603.1|WP_002164578.1|3299090_3300164_+|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP012603.1|WP_001140542.1|3300465_3300894_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP012603.1|WP_002188754.1|3300886_3301069_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP012603_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_9

3286814-3286921

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP012603_9

>merge|NZ_CP012603|9|3286814-3286921|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACCTTCAAAACACGATGCTCCCCGGAGTCGCTGGAACTTGAATATAACTTTGATGCCGTTAGGCGATTTAGAAT

>NZ_CP012603|9|9|3286814-3286921|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	CTTCAAAACACGATGCTCCCCGGAGTCGCTGGAAC
TTGAATATAACTTTGATGCCGTTAGGCGATTTAGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP012603.1\|WP_000110275.1\|3284718_3284922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP012603.1\|WP_001072139.1\|3279548_3279935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000451411.1\|3280118_3280331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188749.1\|3285809_3286043_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188754.1\|3300886_3301069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP012603.1\|WP_157787513.1\|3297516_3297702_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP012603.1\|WP_001110347.1\|3278654_3279206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.4159e-28
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP012603.1|WP_002188749.1|3285809_3286043_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP012603.1|WP_000110275.1|3284718_3284922_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP012603.1|WP_000683530.1|3284313_3284598_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP012603.1|WP_060684644.1|3282688_3284314_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVDLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP012603.1|WP_080010676.1|3282000_3282210_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP012603.1|WP_000578381.1|3280592_3281468_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP012603.1|WP_000451411.1|3280118_3280331_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP012603.1|WP_001072139.1|3279548_3279935_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP012603.1|WP_001110347.1|3278654_3279206_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP012603.1|WP_001971044.1|3276973_3278047_+|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_001216977.1|3289628_3290024_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP012603.1|WP_000026902.1|3290304_3290937_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP012603.1|WP_000601700.1|3290933_3293192_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP012603.1|WP_000098750.1|3293193_3295077_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP012603.1|WP_002188755.1|3295141_3295981_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP012603.1|WP_000371343.1|3296001_3296625_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP012603.1|WP_157787513.1|3297516_3297702_-|hypothetical-protein
MRWPIWIHLRNGVLQSPKRAINLPPAFLTPSIQEYHTSTCLTSKNHTNLRIALENSTQRSL
>NZ_CP012603.1|WP_002164578.1|3299090_3300164_+|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP012603.1|WP_001140542.1|3300465_3300894_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP012603.1|WP_002188754.1|3300886_3301069_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP012603_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_11

3287559-3287666

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP012603_11

>merge|NZ_CP012603|11|3287559-3287666|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACTGTCAGTGACGGCGAATTTCATGAGCCTGCATTTTCTGAATATAACTTTGATGTCGTTAGGCGGTTTAGAAT

>NZ_CP012603|11|11|3287559-3287666|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	TGTCAGTGACGGCGAATTTCATGAGCCTGCATTTT
CTGAATATAACTTTGATGTCGTTAGGCGGTTTAGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP012603.1\|WP_000110275.1\|3284718_3284922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP012603.1\|WP_001072139.1\|3279548_3279935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000451411.1\|3280118_3280331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188749.1\|3285809_3286043_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188754.1\|3300886_3301069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP012603.1\|WP_157787513.1\|3297516_3297702_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP012603.1\|WP_001110347.1\|3278654_3279206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.4159e-28
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP012603.1|WP_002188749.1|3285809_3286043_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP012603.1|WP_000110275.1|3284718_3284922_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP012603.1|WP_000683530.1|3284313_3284598_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP012603.1|WP_060684644.1|3282688_3284314_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVDLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP012603.1|WP_080010676.1|3282000_3282210_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP012603.1|WP_000578381.1|3280592_3281468_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP012603.1|WP_000451411.1|3280118_3280331_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP012603.1|WP_001072139.1|3279548_3279935_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP012603.1|WP_001110347.1|3278654_3279206_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP012603.1|WP_001971044.1|3276973_3278047_+|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_001216977.1|3289628_3290024_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP012603.1|WP_000026902.1|3290304_3290937_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP012603.1|WP_000601700.1|3290933_3293192_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP012603.1|WP_000098750.1|3293193_3295077_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP012603.1|WP_002188755.1|3295141_3295981_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP012603.1|WP_000371343.1|3296001_3296625_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP012603.1|WP_157787513.1|3297516_3297702_-|hypothetical-protein
MRWPIWIHLRNGVLQSPKRAINLPPAFLTPSIQEYHTSTCLTSKNHTNLRIALENSTQRSL
>NZ_CP012603.1|WP_002164578.1|3299090_3300164_+|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP012603.1|WP_001140542.1|3300465_3300894_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP012603.1|WP_002188754.1|3300886_3301069_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP012603_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_13

3288045-3288152

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP012603_13

>merge|NZ_CP012603|13|3288045-3288152|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGTTAGGCGTTGAGCACCTTCAAAACACGATGCTCCCCGGAGTCGCTGGAACCTGAATATAACTTTGATGCCGTTAGGCGATTTAGACG

>NZ_CP012603|13|13|3288045-3288152|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGTTAGGCGTTGAGCAC	CTTCAAAACACGATGCTCCCCGGAGTCGCTGGAAC
CTGAATATAACTTTGATGCCGTTAGGCGATTTAGACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP012603.1\|WP_000110275.1\|3284718_3284922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP012603.1\|WP_001072139.1\|3279548_3279935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000451411.1\|3280118_3280331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188749.1\|3285809_3286043_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188754.1\|3300886_3301069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP012603.1\|WP_157787513.1\|3297516_3297702_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP012603.1\|WP_001110347.1\|3278654_3279206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.4159e-28
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP012603.1|WP_002188749.1|3285809_3286043_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP012603.1|WP_000110275.1|3284718_3284922_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP012603.1|WP_000683530.1|3284313_3284598_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP012603.1|WP_060684644.1|3282688_3284314_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVDLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP012603.1|WP_080010676.1|3282000_3282210_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP012603.1|WP_000578381.1|3280592_3281468_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP012603.1|WP_000451411.1|3280118_3280331_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP012603.1|WP_001072139.1|3279548_3279935_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP012603.1|WP_001110347.1|3278654_3279206_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP012603.1|WP_001971044.1|3276973_3278047_+|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_001216977.1|3289628_3290024_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP012603.1|WP_000026902.1|3290304_3290937_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP012603.1|WP_000601700.1|3290933_3293192_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP012603.1|WP_000098750.1|3293193_3295077_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP012603.1|WP_002188755.1|3295141_3295981_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP012603.1|WP_000371343.1|3296001_3296625_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP012603.1|WP_157787513.1|3297516_3297702_-|hypothetical-protein
MRWPIWIHLRNGVLQSPKRAINLPPAFLTPSIQEYHTSTCLTSKNHTNLRIALENSTQRSL
>NZ_CP012603.1|WP_002164578.1|3299090_3300164_+|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP012603.1|WP_001140542.1|3300465_3300894_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP012603.1|WP_002188754.1|3300886_3301069_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP012603_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_12

3287778-3287888

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP012603_12

>merge|NZ_CP012603|12|3287778-3287888|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGTTAGGCGTTGAGCACAGCGTACTAGGTCGTGAATCACTTACTGGGGCTGAAAACTGAATATAACTTTGATGCCGTTAGGCGATTTAGACG

>NZ_CP012603|12|12|3287778-3287888|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGTTAGGCGTTGAGCAC	AGCGTACTAGGTCGTGAATCACTTACTGGGGCTGAAAA
CTGAATATAACTTTGATGCCGTTAGGCGATTTAGACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP012603.1\|WP_000110275.1\|3284718_3284922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP012603.1\|WP_001072139.1\|3279548_3279935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000451411.1\|3280118_3280331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188749.1\|3285809_3286043_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188754.1\|3300886_3301069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP012603.1\|WP_157787513.1\|3297516_3297702_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP012603.1\|WP_001110347.1\|3278654_3279206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.4159e-28
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP012603.1|WP_002188749.1|3285809_3286043_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP012603.1|WP_000110275.1|3284718_3284922_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP012603.1|WP_000683530.1|3284313_3284598_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP012603.1|WP_060684644.1|3282688_3284314_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVDLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP012603.1|WP_080010676.1|3282000_3282210_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP012603.1|WP_000578381.1|3280592_3281468_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP012603.1|WP_000451411.1|3280118_3280331_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP012603.1|WP_001072139.1|3279548_3279935_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP012603.1|WP_001110347.1|3278654_3279206_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP012603.1|WP_001971044.1|3276973_3278047_+|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_001216977.1|3289628_3290024_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP012603.1|WP_000026902.1|3290304_3290937_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP012603.1|WP_000601700.1|3290933_3293192_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP012603.1|WP_000098750.1|3293193_3295077_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP012603.1|WP_002188755.1|3295141_3295981_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP012603.1|WP_000371343.1|3296001_3296625_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP012603.1|WP_157787513.1|3297516_3297702_-|hypothetical-protein
MRWPIWIHLRNGVLQSPKRAINLPPAFLTPSIQEYHTSTCLTSKNHTNLRIALENSTQRSL
>NZ_CP012603.1|WP_002164578.1|3299090_3300164_+|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP012603.1|WP_001140542.1|3300465_3300894_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP012603.1|WP_002188754.1|3300886_3301069_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP012603_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_10

3287078-3287401

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACAC	PILER-CR

4 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP012603_10

>merge|NZ_CP012603|10|3287078-3287401|CRISPRCasFinder,PILER-CR
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACTGCGAAATAGAAGAACTTTTGATGTTTGATATAAAGCTGAATATAACTTTGATGCCGATAGGCGTTGAGCACACGGACCAACCAGGTATAAAACTCCAACAGATTACCCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACACGGACCAACCAGGTATAAAACTCCAACAGATTACCCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACCCACGAAACAGATACAAAGCCTTCTATTTTTCCCTCTGAATATAACTTTGATGCCGGTAGGCGGTTTAGATG

>NZ_CP012603|10|10|3287078-3287401|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	TGCGAAATAGAAGAACTTTTGATGTTTGATATAAAG
CTGAATATAACTTTGATGCCGATAGGCGTTGAGCAC	ACGGACCAACCAGGTATAAAACTCCAACAGATTACC
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	ACGGACCAACCAGGTATAAAACTCCAACAGATTACC
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	CCACGAAACAGATACAAAGCCTTCTATTTTTCCCT
CTGAATATAACTTTGATGCCGGTAGGCGGTTTAGATG

>NZ_CP012603|10|2|3287150-3287331|PILER-CR
CTGAATATAACTTTGATGCCGATAGGCGTTGAGCACAC	GGACCAACCAGGTATAAAACTCCAACAGATTACC
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACAC	GGACCAACCAGGTATAAAACTCCAACAGATTACC
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP012603.1\|WP_000110275.1\|3284718_3284922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP012603.1\|WP_001072139.1\|3279548_3279935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000451411.1\|3280118_3280331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188749.1\|3285809_3286043_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188754.1\|3300886_3301069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP012603.1\|WP_157787513.1\|3297516_3297702_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP012603.1\|WP_001110347.1\|3278654_3279206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.4159e-28
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP012603.1|WP_002188749.1|3285809_3286043_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP012603.1|WP_000110275.1|3284718_3284922_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP012603.1|WP_000683530.1|3284313_3284598_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP012603.1|WP_060684644.1|3282688_3284314_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVDLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP012603.1|WP_080010676.1|3282000_3282210_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP012603.1|WP_000578381.1|3280592_3281468_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP012603.1|WP_000451411.1|3280118_3280331_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP012603.1|WP_001072139.1|3279548_3279935_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP012603.1|WP_001110347.1|3278654_3279206_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP012603.1|WP_001971044.1|3276973_3278047_+|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_001216977.1|3289628_3290024_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP012603.1|WP_000026902.1|3290304_3290937_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP012603.1|WP_000601700.1|3290933_3293192_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP012603.1|WP_000098750.1|3293193_3295077_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP012603.1|WP_002188755.1|3295141_3295981_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP012603.1|WP_000371343.1|3296001_3296625_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP012603.1|WP_157787513.1|3297516_3297702_-|hypothetical-protein
MRWPIWIHLRNGVLQSPKRAINLPPAFLTPSIQEYHTSTCLTSKNHTNLRIALENSTQRSL
>NZ_CP012603.1|WP_002164578.1|3299090_3300164_+|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP012603.1|WP_001140542.1|3300465_3300894_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP012603.1|WP_002188754.1|3300886_3301069_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP012603_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_16

3289268-3289447

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

2 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP012603_16

>merge|NZ_CP012603|16|3289268-3289447|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGTTAGGCGTTGAGCACAGTTAATCAAAAAGATTCTGAGTATTTTAGAAGAGCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACGGTTCGAAGGCGCTAAGGCTTGGATGAAAGCGCTCGGCTGAATATAACTTTGATGCCGGTAGGCGATTTAGGA

>NZ_CP012603|16|16|3289268-3289447|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGTTAGGCGTTGAGCAC	AGTTAATCAAAAAGATTCTGAGTATTTTAGAAGAG
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	GGTTCGAAGGCGCTAAGGCTTGGATGAAAGCGCTCGG
CTGAATATAACTTTGATGCCGGTAGGCGATTTAGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP012603.1\|WP_000110275.1\|3284718_3284922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP012603.1\|WP_001072139.1\|3279548_3279935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000451411.1\|3280118_3280331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188749.1\|3285809_3286043_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188754.1\|3300886_3301069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP012603.1\|WP_157787513.1\|3297516_3297702_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP012603.1\|WP_001110347.1\|3278654_3279206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.4159e-28
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP012603.1|WP_002188749.1|3285809_3286043_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP012603.1|WP_000110275.1|3284718_3284922_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP012603.1|WP_000683530.1|3284313_3284598_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP012603.1|WP_060684644.1|3282688_3284314_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVDLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP012603.1|WP_080010676.1|3282000_3282210_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP012603.1|WP_000578381.1|3280592_3281468_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP012603.1|WP_000451411.1|3280118_3280331_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP012603.1|WP_001072139.1|3279548_3279935_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP012603.1|WP_001110347.1|3278654_3279206_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP012603.1|WP_001971044.1|3276973_3278047_+|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_001216977.1|3289628_3290024_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP012603.1|WP_000026902.1|3290304_3290937_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP012603.1|WP_000601700.1|3290933_3293192_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP012603.1|WP_000098750.1|3293193_3295077_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP012603.1|WP_002188755.1|3295141_3295981_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP012603.1|WP_000371343.1|3296001_3296625_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP012603.1|WP_157787513.1|3297516_3297702_-|hypothetical-protein
MRWPIWIHLRNGVLQSPKRAINLPPAFLTPSIQEYHTSTCLTSKNHTNLRIALENSTQRSL
>NZ_CP012603.1|WP_002164578.1|3299090_3300164_+|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP012603.1|WP_001140542.1|3300465_3300894_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP012603.1|WP_002188754.1|3300886_3301069_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP012603_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_14

3288309-3288629

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	PILER-CR

4 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP012603_14

>merge|NZ_CP012603|14|3288309-3288629|CRISPRCasFinder,CRT,PILER-CR
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACGAATAACTCGTTCGGAAAGCGTTCTGCGGATCTTCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACTTGATCGAAAGTCTTCGAATATTAAAATCCGATCCCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACGACAGAATATTAAAAACGAAAGAACAAGAAATCTTGCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTTGATCACGACCGGGACTTTGATTGCTGTAGCTATCTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

>NZ_CP012603|14|14|3288309-3288629|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	GAATAACTCGTTCGGAAAGCGTTCTGCGGATCTT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTGATCGAAAGTCTTCGAATATTAAAATCCGATCC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GACAGAATATTAAAAACGAAAGAACAAGAAATCTTG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTGATCACGACCGGGACTTTGATTGCTGTAGCTAT
CTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

>NZ_CP012603|14|2|3288309-3288628|CRT
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	GAATAACTCGTTCGGAAAGCGTTCTGCGGATCTT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTGATCGAAAGTCTTCGAATATTAAAATCCGATCC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GACAGAATATTAAAAACGAAAGAACAAGAAATCTTG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTGATCACGACCGGGACTTTGATTGCTGTAGCTAT
CTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAA

>NZ_CP012603|14|3|3288379-3288557|PILER-CR
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTGATCGAAAGTCTTCGAATATTAAAATCCGATCC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GACAGAATATTAAAAACGAAAGAACAAGAAATCTTG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP012603.1\|WP_000110275.1\|3284718_3284922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP012603.1\|WP_001072139.1\|3279548_3279935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000451411.1\|3280118_3280331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188749.1\|3285809_3286043_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188754.1\|3300886_3301069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP012603.1\|WP_157787513.1\|3297516_3297702_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP012603.1\|WP_001110347.1\|3278654_3279206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.4159e-28
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP012603.1|WP_002188749.1|3285809_3286043_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP012603.1|WP_000110275.1|3284718_3284922_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP012603.1|WP_000683530.1|3284313_3284598_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP012603.1|WP_060684644.1|3282688_3284314_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVDLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP012603.1|WP_080010676.1|3282000_3282210_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP012603.1|WP_000578381.1|3280592_3281468_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP012603.1|WP_000451411.1|3280118_3280331_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP012603.1|WP_001072139.1|3279548_3279935_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP012603.1|WP_001110347.1|3278654_3279206_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP012603.1|WP_001971044.1|3276973_3278047_+|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_001216977.1|3289628_3290024_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP012603.1|WP_000026902.1|3290304_3290937_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP012603.1|WP_000601700.1|3290933_3293192_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP012603.1|WP_000098750.1|3293193_3295077_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP012603.1|WP_002188755.1|3295141_3295981_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP012603.1|WP_000371343.1|3296001_3296625_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP012603.1|WP_157787513.1|3297516_3297702_-|hypothetical-protein
MRWPIWIHLRNGVLQSPKRAINLPPAFLTPSIQEYHTSTCLTSKNHTNLRIALENSTQRSL
>NZ_CP012603.1|WP_002164578.1|3299090_3300164_+|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP012603.1|WP_001140542.1|3300465_3300894_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP012603.1|WP_002188754.1|3300886_3301069_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP012603_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_15

3288787-3289111

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	PILER-CR

4 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP012603_15

>merge|NZ_CP012603|15|3288787-3289111|CRISPRCasFinder,CRT,PILER-CR
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACTTATACGACGAGAGCGAGGTGGCGGCTCTGTTACGCCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACGCAAATTGAGTTTTAGGATTTCTGCTACAATATCTTTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACCATTTTTGCTCTTCCTTAATATTCATTTTGTTTACTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACACTTAAGACCAAATCGTAACGTCTGGTTTGAGACTCTGAATATAACTTTGATGCCGTTAGGCGATTTAGACA

>NZ_CP012603|15|15|3288787-3289111|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	TTATACGACGAGAGCGAGGTGGCGGCTCTGTTACGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GCAAATTGAGTTTTAGGATTTCTGCTACAATATCTTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CATTTTTGCTCTTCCTTAATATTCATTTTGTTTACT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACTTAAGACCAAATCGTAACGTCTGGTTTGAGACT
CTGAATATAACTTTGATGCCGTTAGGCGATTTAGACA

>NZ_CP012603|15|3|3288787-3289110|CRT
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	TTATACGACGAGAGCGAGGTGGCGGCTCTGTTACGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GCAAATTGAGTTTTAGGATTTCTGCTACAATATCTTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CATTTTTGCTCTTCCTTAATATTCATTTTGTTTACT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACTTAAGACCAAATCGTAACGTCTGGTTTGAGACT
CTGAATATAACTTTGATGCCGTTAGGCGATTTAGAC

>NZ_CP012603|15|4|3288859-3289039|PILER-CR
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GCAAATTGAGTTTTAGGATTTCTGCTACAATATCTTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CATTTTTGCTCTTCCTTAATATTCATTTTGTTTACT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP012603.1\|WP_000110275.1\|3284718_3284922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP012603.1\|WP_001072139.1\|3279548_3279935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000451411.1\|3280118_3280331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188749.1\|3285809_3286043_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188754.1\|3300886_3301069_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP012603.1\|WP_157787513.1\|3297516_3297702_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP012603.1\|WP_001110347.1\|3278654_3279206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_000683530.1\|3284313_3284598_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP012603.1\|WP_000578381.1\|3280592_3281468_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP012603.1\|WP_002164578.1\|3299090_3300164_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.4159e-28
NZ_CP012603.1\|WP_000098750.1\|3293193_3295077_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP012603.1\|WP_002188755.1\|3295141_3295981_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP012603.1\|WP_000371343.1\|3296001_3296625_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP012603.1\|WP_000026902.1\|3290304_3290937_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP012603.1\|WP_000601700.1\|3290933_3293192_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP012603.1\|WP_080010676.1\|3282000_3282210_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP012603.1\|WP_001216977.1\|3289628_3290024_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP012603.1\|WP_060684644.1\|3282688_3284314_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP012603.1\|WP_001140542.1\|3300465_3300894_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP012603.1\|WP_001971044.1\|3276973_3278047_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP012603.1|WP_002188749.1|3285809_3286043_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP012603.1|WP_000110275.1|3284718_3284922_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP012603.1|WP_000683530.1|3284313_3284598_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP012603.1|WP_060684644.1|3282688_3284314_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVDLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP012603.1|WP_080010676.1|3282000_3282210_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP012603.1|WP_000578381.1|3280592_3281468_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP012603.1|WP_000451411.1|3280118_3280331_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP012603.1|WP_001072139.1|3279548_3279935_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP012603.1|WP_001110347.1|3278654_3279206_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP012603.1|WP_001971044.1|3276973_3278047_+|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP012603.1|WP_001216977.1|3289628_3290024_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP012603.1|WP_000026902.1|3290304_3290937_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP012603.1|WP_000601700.1|3290933_3293192_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP012603.1|WP_000098750.1|3293193_3295077_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP012603.1|WP_002188755.1|3295141_3295981_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP012603.1|WP_000371343.1|3296001_3296625_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP012603.1|WP_157787513.1|3297516_3297702_-|hypothetical-protein
MRWPIWIHLRNGVLQSPKRAINLPPAFLTPSIQEYHTSTCLTSKNHTNLRIALENSTQRSL
>NZ_CP012603.1|WP_002164578.1|3299090_3300164_+|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP012603.1|WP_001140542.1|3300465_3300894_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP012603.1|WP_002188754.1|3300886_3301069_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP012603_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012603_17

3754758-3754872

Orphan

Consensus_repeat	Method
AATAGAGTAGTTGAAAAATAAATTCTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012603_17

>merge|NZ_CP012603|17|3754758-3754872|CRISPRCasFinder
AATAGAGTAGTTGAAAAATAAATTCTCCTATCTGTTTCTATTTTATGGAAACGGTCGATTGAAATAGTTTTGTTAATCCCGCTATAGAATAGAGTAGTTGAAAAATTAATTCTCC

>NZ_CP012603|17|17|3754758-3754872|CRISPRCasFinder
AATAGAGTAGTTGAAAAATAAATTCTCC	TATCTGTTTCTATTTTATGGAAACGGTCGATTGAAATAGTTTTGTTAATCCCGCTATAG
AATAGAGTAGTTGAAAAATTAATTCTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012603.1\|WP_002189465.1\|3760179_3762078_-\|DUF1561-domain-containing-protein	unknown	unknown	gnl\|CDD\|284921
NZ_CP012603.1\|WP_000738676.1\|3764016_3764937_+\|lipase	unknown	unknown	gnl\|CDD\|224001
NZ_CP012603.1\|WP_000688306.1\|3748278_3749112_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_CP012603.1\|WP_001008156.1\|3750361_3750607_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012603.1\|WP_002189443.1\|3755472_3757692_-\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NZ_CP012603.1\|WP_000952672.1\|3767413_3770530_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226220
NZ_CP012603.1\|WP_001216306.1\|3743985_3744735_-\|FtsQ-type-POTRA-domain-containing-protein	unknown	unknown	gnl\|CDD\|369897
NZ_CP012603.1\|WP_000656645.1\|3752720_3753176_+\|GyrI-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|214874
NZ_CP012603.1\|WP_060589297.1\|3762259_3762508_-\|DUF1563-domain-containing-protein	unknown	unknown	gnl\|CDD\|203693
NZ_CP012603.1\|WP_033108074.1\|3759825_3759960_-\|DUF1563-domain-containing-protein	unknown	unknown	gnl\|CDD\|203693
NZ_CP012603.1\|WP_001054065.1\|3745417_3746218_+\|MCE-family-protein	unknown	unknown	gnl\|CDD\|367096
NZ_CP012603.1\|WP_000570773.1\|3746892_3747423_-\|SET-domain-containing-protein	unknown	unknown	gnl\|CDD\|380940
NZ_CP012603.1\|WP_060684645.1\|3751751_3752423_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|131984
NZ_CP012603.1\|WP_162490610.1\|3765468_3766542_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP012603.1\|WP_000481668.1\|3751098_3751692_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|376578
NZ_CP012603.1\|WP_000183410.1\|3754064_3754691_+\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|198303
NZ_CP012603.1\|WP_000681097.1\|3757906_3758200_-\|metal-sensing-transcriptional-repressor	unknown	unknown	gnl\|CDD\|197387
NZ_CP012603.1\|WP_000659126.1\|3757688_3757889_-\|copper-resistance-protein-CopZ	unknown	unknown	gnl\|CDD\|225127
NZ_CP012603.1\|WP_002189487.1\|3758572_3759514_-\|DUF1561-family-protein	unknown	unknown	gnl\|CDD\|284921
NZ_CP012603.1\|WP_000684307.1\|3749108_3750365_-\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|225459

Protein	Function_ID	Function_description	E-value
NZ_CP012603.1\|WP_002189465.1\|3760179_3762078_-\|DUF1561-domain-containing-protein	gnl\|CDD\|284921	pfam07598, DUF1561, Protein of unknown function (DUF1561). A family of paralogous proteins in Leptospira interrogans.	0
NZ_CP012603.1\|WP_000738676.1\|3764016_3764937_+\|lipase	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	2.75616e-17
NZ_CP012603.1\|WP_000688306.1\|3748278_3749112_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	3.72642e-09
NZ_CP012603.1\|WP_002189443.1\|3755472_3757692_-\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP012603.1\|WP_000952672.1\|3767413_3770530_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|226220	COG3696, COG3696, Putative silver efflux pump [Inorganic ion transport and metabolism].	0
NZ_CP012603.1\|WP_001216306.1\|3743985_3744735_-\|FtsQ-type-POTRA-domain-containing-protein	gnl\|CDD\|369897	pfam08478, POTRA_1, POTRA domain, FtsQ-type. FtsQ/DivIB bacterial division proteins (pfam03799) contain an N-terminal POTRA domain (for polypeptide-transport-associated domain). This is found in different types of proteins, usually associated with a transmembrane beta-barrel. FtsQ/DivIB may have chaperone-like roles, which has also been postulated for the POTRA domain in other contexts.	1.31152e-13
NZ_CP012603.1\|WP_000656645.1\|3752720_3753176_+\|GyrI-like-domain-containing-protein	gnl\|CDD\|214874	smart00871, AraC_E_bind, Bacterial transcription activator, effector binding domain. This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.	6.69035e-18
NZ_CP012603.1\|WP_060589297.1\|3762259_3762508_-\|DUF1563-domain-containing-protein	gnl\|CDD\|203693	pfam07599, DUF1563, Protein of unknown function (DUF1563). A small family of short hypothetical proteins in Leptospira interrogans.	3.22718e-15
NZ_CP012603.1\|WP_033108074.1\|3759825_3759960_-\|DUF1563-domain-containing-protein	gnl\|CDD\|203693	pfam07599, DUF1563, Protein of unknown function (DUF1563). A small family of short hypothetical proteins in Leptospira interrogans.	2.44197e-16
NZ_CP012603.1\|WP_001054065.1\|3745417_3746218_+\|MCE-family-protein	gnl\|CDD\|367096	pfam02470, MlaD, MlaD protein. This family of proteins contains MlaD, which is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. The family also contains the mce (mammalian cell entry) proteins from Mycobacterium tuberculosis. The archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. This family contains proteins of unknown function from other bacteria.	4.90451e-13
NZ_CP012603.1\|WP_000570773.1\|3746892_3747423_-\|SET-domain-containing-protein	gnl\|CDD\|380940	cd10542, SET_SUV39H, SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins. This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.	2.782e-17
NZ_CP012603.1\|WP_060684645.1\|3751751_3752423_-\|PAS-domain-S-box-protein	gnl\|CDD\|131984	TIGR02938, Nitrogen_fixation_regulatory_protein, nitrogen fixation negative regulator NifL. NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions].	2.10887e-12
NZ_CP012603.1\|WP_162490610.1\|3765468_3766542_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.85067e-28
NZ_CP012603.1\|WP_000481668.1\|3751098_3751692_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|376578	pfam01625, PMSR, Peptide methionine sulfoxide reductase. This enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine.	9.9266e-88
NZ_CP012603.1\|WP_000183410.1\|3754064_3754691_+\|glutathione-S-transferase-family-protein	gnl\|CDD\|198303	cd03194, GST_C_3, C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases. Glutathione S-transferase (GST) C-terminal domain family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain.	4.8177e-58
NZ_CP012603.1\|WP_000681097.1\|3757906_3758200_-\|metal-sensing-transcriptional-repressor	gnl\|CDD\|197387	cd10152, SaCsoR-like_DUF156, Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156. This domain family includes Staphylococcus aureus CsoR (SaCsoR). SaCsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis; it represses a genetically unlinked copA-copZ operon. copA encodes a copper efflux P-type ATPase, and copZ, a copper chaperone. This family belongs to a larger superfamily that contains various transcriptional regulators that respond to different stressors such as Cu(I), Ni(I), sulfite, and formaldehyde, and includes Mycobacterium tuberculosis CsoR (MtCsoR), Bacillus subtilis CsoR, and Thermus thermophilus CsoR. The latter three proteins do not belong to this family. CsoRs form homotetramers (dimer of dimers). In MtCsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily, including this family, and a conserved Tyr and a Glu residue that facilitate allosteric regulation of DNA binding for CsoRs are also well conserved.	3.95318e-36
NZ_CP012603.1\|WP_000659126.1\|3757688_3757889_-\|copper-resistance-protein-CopZ	gnl\|CDD\|225127	COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism].	4.56214e-08
NZ_CP012603.1\|WP_002189487.1\|3758572_3759514_-\|DUF1561-family-protein	gnl\|CDD\|284921	pfam07598, DUF1561, Protein of unknown function (DUF1561). A family of paralogous proteins in Leptospira interrogans.	2.38695e-163
NZ_CP012603.1\|WP_000684307.1\|3749108_3750365_-\|NAD(P)-binding-protein	gnl\|CDD\|225459	COG2907, COG2907, Predicted NAD/FAD-binding protein [General function prediction only].	3.58781e-53

>NZ_CP012603.1|WP_000183410.1|3754064_3754691_+|glutathione-S-transferase-family-protein
MTNLQLVIGDKKLSSWSMRPWILLKEKNIPFIEISLTLNTPEFYEKIKLYSNASKVPVLIDGDIKIWDTNSIVEYLAETFPEKNLWPKDKTLRAIARSIVAEMHSGFSDLRKNLPMKIIERLYGKSFPEEVWKDIQRIESIWKDCLNLYQGPFLFGKEFTIADAFYTPVVGRFITYGIELDSEANKYVSTISGLHSYKEWIEEALKSK
>NZ_CP012603.1|WP_000656645.1|3752720_3753176_+|GyrI-like-domain-containing-protein
MKECLMPKKYLIGIGTRTKNENEMGSNGNIPKLWEKFFGEVLPKLKTTDKFIYAVYKDYESDENGEYSYFIGVPSDEINIFETVQLPEGKYLELTSLKGKSPNIVIELWQKVWTNSDIKRRRAFEVDYEIYPIDFSETPETQVHLLLSVKD
>NZ_CP012603.1|WP_060684645.1|3751751_3752423_-|PAS-domain-S-box-protein
MNLSSILVSYFYQYPHAMFITNRCGMIEYINPVFETLSGYSRSELIGQNPKLFQAGVHDPNFYEELWKTILSGKEYEGNFLNRNGSGETIAWKERITPLRDEAGNISNFLCRVDLSSKDEVSAVPTEEQSMPVENFQNTKVKESLFPQLQREYGLTCQEAKICERLVAGQTRACLIQQLGVHSGTLKNHLKAIYRKTIKKDLPQPGQGRDKLQRLTMFLIRLC
>NZ_CP012603.1|WP_000481668.1|3751098_3751692_+|peptide-methionine-(S)-S-oxide-reductase-MsrA
MFNFKILIFIYIIFFSPNLMATPKTEKATFAGGCFWCMEGPFESLPGVISVVAGYSGGKEFYPTYQEVSRGKTGHRESVQIEFDSSKIRYEELLTVFWNQIDPTDNGGQFADRGNQYRTGIFYHNQTQKKAAEKSKREISESKKFPGSIVVEIIPFTSFYPAEDYHQNYYKTNSEQYKKYKKYSGREDYLEKMCRQR
>NZ_CP012603.1|WP_001008156.1|3750361_3750607_-|hypothetical-protein
MNEYLLSSDKYFIQKNVCKRIEIISQVKKEHQTYTPTKGLKFSLRIDSIIKKSFERINMIFILKEKNPMFSFQKSKIKNQI
>NZ_CP012603.1|WP_000684307.1|3749108_3750365_-|NAD(P)-binding-protein
MKIAILGSGIAGLSACWYLSKEHDVILIERHSLPGMDAHGTDISLKDGVFRFDVPFRAFKQNYYPCLIEMYNEAGIEFRPVDYSFSLSERDGTTYFQFATIGIGGNFYPFVSPVCFKNGESRKIFSDTIRFYGESAKQLESLRGEQLTISGFLQRFGYSKEFENKYLIPMFATINTCTILSAKNYPAEAVIRYHSKGLKFLRFLTASHGTKDITEKLSIGAKELRLKTNPRKIEQNGKKVFVSFDDGKEEFDRVIIATPANQAISLLPDEMAPEKELLSSFHYEESEILMHTDPSFMPNKKRHWAPLCFTLSPETDKPSATIRLNKVLPEIGKVEIFQTWNPLEEPKRGTLISRSRFERPIIDLKNQKTVEKLKALQEQPGRKIWFCGSYARYGIPLLEAGVSTSLDVKRWVENSERF
>NZ_CP012603.1|WP_000688306.1|3748278_3749112_+|class-I-SAM-dependent-methyltransferase
MKIFFKKKRIEAPDTLAHLYLNPKNSSWANFGYWKDTTDYPTACKELALLLGRKADLKPGLKVLDLGFGCGDQFFVWKEKFSLNFSDLVGVNGSFVQTEFAKKLIESKSNVSPKLICSSVEKAILSFPHQSLDRILCLDSASFFSDRIEFCKQAFKILKPGGKLVSAELILKNSKLGMIDSWFRKMICKSGSIPKNNRVTPDSLSQLLRSSGFLLEGFDFLEKYIFEGFSNFLKMKSKESSIPKEISRKYSYFAEFLGGERMKKYFQFVLYSAVKPD
>NZ_CP012603.1|WP_000570773.1|3746892_3747423_-|SET-domain-containing-protein
MIEKRINKFGENGTFATKDIPKGTLLFSYSEWIEDEEFGWKVLTVEEAESLPDSEKDIFMKYGYDVDFGLVTGPTSDQYVINHSNFMNHSCDPNMWYDQDDNIVAKRDIRAGEELTIDYANFIVNFDQTFECGCGSVNCRKFIRKDDWKLLVNEYQMNFPKFIQKEIKKLYVKIPV
>NZ_CP012603.1|WP_001054065.1|3745417_3746218_+|MCE-family-protein
MNLSKHTAVLTGIVFFLAFSLSMYVSVIEKAGTKDEYPYTMKIYYPRLEGIHPGAPVRILGVEKGIVRSLDVVPIDEVEDQRFLNKDQTKAIEIIVRLKEPITLWDNYKITFQTNTILSGRTIDIDPGSFDKEETSFFQPTYLEEEQKSPDFLPSADYFEDFFAASTGVIRENREDIRTSFNNFYEISEKLKSNRGTIPQIINSPETYDNVIELLTDARIFGNDARRYLEGNRKLERSAPIPLTINMYRRTTLIGNVSNRYYFGKL
>NZ_CP012603.1|WP_001216306.1|3743985_3744735_-|FtsQ-type-POTRA-domain-containing-protein
MRHNLIDFLREFVQKRRNVLLLALLIGILSIGMILGFGYQGMIPRELNKLIITGHEKLKTEEIVRMLEIQPGTSFDSLDLDLLEKKLSRLPRINSVRITKKSEDQLLVELTERKASYVVNSSGHLYEIDSELRLLSQDDIREKDLCVLSGNFQIKGGAIQDASFRDLYNSVEHAFKMYPALKPRISEVLLQEDGEIFFFADEPIRLRIQIGTLLHRDQVRKLYAILAYFEKDRIQSELVDIRGEDAVYH
>NZ_CP012603.1|WP_002189443.1|3755472_3757692_-|copper-translocating-P-type-ATPase
MKVQQELHLNEVTLDVIGMTCANCALRIEKGLKKIPGVKDVRVNFAMETAKIDFESSISKEILMDKIDFLGYRAVVHEDIQIDGEIQKKEFKKLKVRVIVSAFLSLPLLLSMIGHFENNLNFEYLSFLMNPWLQFILATPIQFWIGASFYKGSFRALRNGGANMDVLVVLGTSAAYFYSVYLTFIFNEKYIHKTANLYYETSSVLITLILFGKLLEHIVKGKSSKAIQSLVNLQPKKANVIREKEIQEIPLLAVRSGDLILVKPGESIPVDGIIEEGSSTIDESMLTGESIPVEKTISNFVYGGSLNQNGTFKFRALKVGKETLLSGIIRAVREAQGTKAPIQRIADQISEIFVPVIVLISVITLCVWYFWILPSTFSVALEKAIAVLVVACPCALGLATPISVLTGSGKAATMGILFRSAEALEILHKVNAIVFDKTGTLTYGKLVLKSLESLNIAKENNLLTLAASAEQNSEHPLSKAIVESAKKKGLVLAIPENFETIPGGGISAIVEGNRILIGTERLFYAKGIELNQELNNLKRIREEEGNTVVHLSVNEIHSAILTLADTLKESTPATIAKLKSLGIEVYMITGDNERTARVISKDCGIERVLAEVLPEKKAMEVKNLKSLGKVVSMVGDGINDAPALAISDLGIAMGTGTDVAMESSDLVIVNGDLNSIVNAITISRKTVYNIRQNFFWALLYNTLGIPIAAAGFLAPWVAGGAMALSSVSVVLNALRLQRD
>NZ_CP012603.1|WP_000659126.1|3757688_3757889_-|copper-resistance-protein-CopZ
MKEIRLTVEGMTCLHCLKTIESALKEAGFTGKANLENREVVYYGKGTTEELSKVKETILKKGYKPE
>NZ_CP012603.1|WP_000681097.1|3757906_3758200_-|metal-sensing-transcriptional-repressor
MKHKPKHKLISDPKESKNLILRLKKIEGQIRGIQGMIENEKYCDDVLNQISSVKSALDGVSRGLLKSHIRTCVTERIRENDSKILEEFMTTVGYILR
>NZ_CP012603.1|WP_002189487.1|3758572_3759514_-|DUF1561-family-protein
MGRWIVLLLVLLISLGVGYSYGVNPDQYCPASKKENHNIRIKRTLPPNFQLTEEWLRRLYDIATSASLTEGQIHGICGVCLLQTFQMLAELQEYHSHGPLQSGGYFFNTAPDTDPFDSFRQRYPELDTMLTDAATAYGPAYNTTRLLTLVSAMTMMPQYEWTPSREFTTRSDMHSHIRSLIDSPPGSIWLGLMQRRESDETLRWHALPILRTSQGLIVIQTRVSTMSFELYRLYLTPSTSIVQIINDYLEEADRTLTVLVTIQLEQAYQNLFDFMVSNMNCTGEGENRRGSGGYPTSATVNQCSGGRCALPNW
>NZ_CP012603.1|WP_033108074.1|3759825_3759960_-|DUF1563-domain-containing-protein
MMNIILIGFFLLETLENLYTTYVECSLKQIFLDKTQKIFKANRK
>NZ_CP012603.1|WP_002189465.1|3760179_3762078_-|DUF1561-domain-containing-protein
MGRWIVLLLVLLISFGVGYSYGVNPDVVPISSSDIPGSIIQRPTDKPKDKPIKVNVSSGGTFCYGPNFSGGESYIVIEQCWQMHVMNARYDVFQRISYNINDTWLCITVSESVVKGETNWDYVHLRPCTINNPLQRWIVKENSFWTADERYRLKDTNWYAYISRNSGDRYNHTLDSSMSDWINTVATPGNISILTSIAWDLGSDRYFIRSGGSDKNTTPIYYNPESGHLAQYNPVSGLLSCMYSRVGSYDWNWVTWALCSDAPISKDNPAYWNVYLATEEGGMIMDYQGNALRVTRYGPNWGVAYAAKLSYLKKDTTYNPTSLFIVDRNLLNWVRYTVSNLGKTDQYCPAGKKENHNIRIKRTLPPDFQLTEEWLRRLYDIAISTSFTSEGQVHGICGTCLLQTFQMLAELQEYHSHGPIQGGGYFFNTAHDRDPFDSFRQRYPELDAMLVNIPIVYSQDGNVPRMGLASARTMLPQYDWTLSREFTTRSEMLSHITSLIASPPGSMWLSMFRVRRPDGTTGGHAVPILRTSQGLVVIPTNSASLSFFTYRRFATPTTDPVQVMNNLEMSSWTLEILVTAQLEGLYYNTFDFTISNRNCTGEGRDRRGSGGYPTRTTVNQCSGRGGGRCVLL
>NZ_CP012603.1|WP_060589297.1|3762259_3762508_-|DUF1563-domain-containing-protein
MMNIILIGFFLLETLENLYATYVEYFLKQTFLDSIQKISKMDQKQNEIPVLPIFKILIFQVISSKGIFLNLSDNKIYQRYKL
>NZ_CP012603.1|WP_000738676.1|3764016_3764937_+|lipase
MKKMNLKILLTLVFLITNVTYASGGGTSSKPLSGSYPIVLAHGLFGWGNGSTVVDYWGGNAAYLRNQGAYVLTPSVTALNSSSSRASQLKTSILAAMAANNYTGKVHIIGHSQGGLDARYMVSNLSMSTKVATLTTLNTPHQGSPIANIVAAVIPNWALPYVSTVLNTIIGFVYGDSSQNAISALKLLTTDGLKTFNSVTPNVSGVKYFSYGSTISVPDLIQHPAMGILHPICAIGAPFYGMSIANDGVVPDSSQRWGTWKGGPSIPILTTGIDHLEATNALYLGQLWYDTNAYFLKMANNAKSNQ
>NZ_CP012603.1|WP_162490610.1|3765468_3766542_-|IS110-family-transposase
MESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEKEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLAQYGLM
>NZ_CP012603.1|WP_000952672.1|3767413_3770530_-|efflux-RND-transporter-permease-subunit
MLSRLLNISLSNPILSTGTVFFLFIYSFFTLKDVPIDAVPDITNTQVIVIAKTGSLDPEQVEKVVTFPLETELMGMPNLIDVRSVSKFGLSNISLIFKEGTDIYQARSMVLERISSAQEKLPKGISPTIVPNTTGLGEIFFYTVEAKQGSKLASLPEKERLLYLRTVQDYTVRPQIKALVPGIVEVDSNGGYEKEIHIDLNPNKMKFWGITIDQLIGELSTIGESFGGGFIENDGKLAIVRAYGIKKSLNSLSEVTVRRTLTGSPIRVSDIAEVKEHGKQRLGGASSEGKEIVLGTAMMLRGENSFQVNSDLNRAVSLLKLPEDVQVRILLERSFLIHSTILTVTKNLSEGAVLVILTLFFILYNIKASIIVAAIIPGSMLLTAIFMKVFGISANLMSLGAIDFGLLVDASIVITENVLTRFERDAIFSREEKIRTILNASLEVLKPVSFGIVVIMLVYVPIFTLDGIPGKMFRPMAQTVLFALGFSLILAVFFLPPLLFFFITPPKRIVNQEVKKSRIVILYETYLPVLLKKPKLIIIGSILFFLLTLFIYFRMGTVFLPKLMEGDLMLVIVREGDISIEESLKEQKEVEKLLMQMPEIQSVFSRIGTSSVANDPMGTFNADTFIILKKESLNDLLEEKNWENLLNRIHKKVQESFPKSELTLSQPLEARFNELLEGSRADISVRILGKDLNTLLDLQNSLKDILHNIPGAAEVELDPIMALRKSTVVDIIPDPFKLKYYNISLPLFNSAVESSMSGFELGGYYEEEVRFPIKIWLSEEFRNHESEISNIGIGTEDGGMIPIKLLASIEKKEKIMTISRNKSRRFVAVSVNLRGRDLEGFYSEAKDKISNMNIPQGYSVFWGGQIENLSKAKDKLSVILPSTFLMIFVVLYLGLKSVRRALLVFFCVPFALTGGIWLLFLRGMDLSVSAFVGCIALSGISVLNGLVKLDTIHRIREKEKISLRDAVLKGATSRIRPVIMTALVASFGFMPMAFGSGLGSEVQKPLATVVIGGIVSSTILTLVILPVFYYWLEDDFKN

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Identity
NZ_CP012603_3	3.1\|2748198\|46\|NZ_CP012603\|CRISPRCasFinder	2748198-2748243	46	NZ_CP012603.1	979448-979493	1.0
NZ_CP012603_3	3.1\|2748198\|46\|NZ_CP012603\|CRISPRCasFinder	2748198-2748243	46	NZ_CP012603.1	2720727-2720772	1.0
NZ_CP012603_3	3.1\|2748198\|46\|NZ_CP012603\|CRISPRCasFinder	2748198-2748243	46	NZ_CP012603.1	2841662-2841707	1.0
NZ_CP012603_3	3.1\|2748198\|46\|NZ_CP012603\|CRISPRCasFinder	2748198-2748243	46	NZ_CP012603.1	2841733-2841778	1.0
NZ_CP012603_3	3.1\|2748198\|46\|NZ_CP012603\|CRISPRCasFinder	2748198-2748243	46	NZ_CP012603.1	3566022-3566067	1.0
NZ_CP012603_3	3.1\|2748198\|46\|NZ_CP012603\|CRISPRCasFinder	2748198-2748243	46	NZ_CP012603.1	4126490-4126535	1.0
NZ_CP012603_3	3.1\|2748198\|46\|NZ_CP012603\|CRISPRCasFinder	2748198-2748243	46	NZ_CP012603.1	4126560-4126605	1.0

1. spacer 3.1|2748198|46|NZ_CP012603|CRISPRCasFinder matches to position: 979448-979493, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

2. spacer 3.1|2748198|46|NZ_CP012603|CRISPRCasFinder matches to position: 2720727-2720772, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

3. spacer 3.1|2748198|46|NZ_CP012603|CRISPRCasFinder matches to position: 2841662-2841707, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

4. spacer 3.1|2748198|46|NZ_CP012603|CRISPRCasFinder matches to position: 2841733-2841778, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

5. spacer 3.1|2748198|46|NZ_CP012603|CRISPRCasFinder matches to position: 3566022-3566067, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

6. spacer 3.1|2748198|46|NZ_CP012603|CRISPRCasFinder matches to position: 4126490-4126535, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

7. spacer 3.1|2748198|46|NZ_CP012603|CRISPRCasFinder matches to position: 4126560-4126605, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP012603_5	5.4\|3285217\|36\|NZ_CP012603\|PILER-CR,CRISPRCasFinder,CRT	3285217-3285252	36	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	821-856	0	1.0
NZ_CP012603_5	5.5\|3285289\|37\|NZ_CP012603\|PILER-CR,CRISPRCasFinder,CRT	3285289-3285325	37	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	53283-53319	0	1.0
NZ_CP012603_5	5.6\|3285362\|37\|NZ_CP012603\|PILER-CR,CRISPRCasFinder,CRT	3285362-3285398	37	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	50052-50088	0	1.0
NZ_CP012603_16	16.1\|3289304\|35\|NZ_CP012603\|CRISPRCasFinder	3289304-3289338	35	NZ_CP040842	Leptospira weilii strain CUDO6 plasmid pDO6, complete sequence	54220-54254	0	1.0
NZ_CP012603_16	16.1\|3289304\|35\|NZ_CP012603\|CRISPRCasFinder	3289304-3289338	35	NZ_CP040845	Leptospira weilii strain CUD13 plasmid pD13, complete sequence	60471-60505	0	1.0
NZ_CP012603_10	10.4\|3287330\|35\|NZ_CP012603\|CRISPRCasFinder	3287330-3287364	35	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	7368-7402	1	0.971
NZ_CP012603_12	12.1\|3287814\|38\|NZ_CP012603\|CRISPRCasFinder	3287814-3287851	38	NZ_CP039286	Leptospira interrogans strain FMAS_AW1 plasmid pLiSL3, complete sequence	66415-66452	1	0.974
NZ_CP012603_15	15.2\|3288895\|37\|NZ_CP012603\|CRISPRCasFinder,CRT,PILER-CR	3288895-3288931	37	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	6936-6972	1	0.973
NZ_CP012603_7	7.1\|3286324\|35\|NZ_CP012603\|CRISPRCasFinder	3286324-3286358	35	NZ_CP006725	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence	25961-25995	3	0.914
NZ_CP012603_7	7.1\|3286324\|35\|NZ_CP012603\|CRISPRCasFinder	3286324-3286358	35	NZ_CP039285	Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence	54324-54358	3	0.914
NZ_CP012603_5	5.2\|3285072\|36\|NZ_CP012603\|PILER-CR,CRISPRCasFinder,CRT	3285072-3285107	36	NZ_CP039285	Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence	52974-53009	5	0.861
NZ_CP012603_5	5.2\|3285072\|36\|NZ_CP012603\|PILER-CR,CRISPRCasFinder,CRT	3285072-3285107	36	NZ_CP006725	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence	27310-27345	5	0.861
NZ_CP012603_5	5.10\|3285651\|35\|NZ_CP012603\|PILER-CR,CRISPRCasFinder,CRT	3285651-3285685	35	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	2876-2910	6	0.829
NZ_CP012603_16	16.1\|3289304\|35\|NZ_CP012603\|CRISPRCasFinder	3289304-3289338	35	HQ633071	Synechococcus phage S-SKS1 genomic sequence	140881-140915	7	0.8
NZ_CP012603_16	16.1\|3289304\|35\|NZ_CP012603\|CRISPRCasFinder	3289304-3289338	35	NC_017791	Deinococcus gobiensis I-0 plasmid P2, complete sequence	98983-99017	8	0.771
NZ_CP012603_15	15.3\|3288968\|36\|NZ_CP012603\|CRISPRCasFinder,CRT,PILER-CR	3288968-3289003	36	MG675557	Pseudoalteromonas phage Maelstrom, complete genome	1991-2026	9	0.75
NZ_CP012603_10	10.1\|3287114\|36\|NZ_CP012603\|CRISPRCasFinder	3287114-3287149	36	NC_011777	Bacillus cereus AH820 plasmid pAH820_272, complete sequence	22200-22235	10	0.722

1. spacer 5.4|3285217|36|NZ_CP012603|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 0, identity: 1.0

ttttggacaacaacttcctcgctccccgcatgttct	CRISPR spacer
ttttggacaacaacttcctcgctccccgcatgttct	Protospacer
************************************

2. spacer 5.5|3285289|37|NZ_CP012603|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 0, identity: 1.0

taacaacatagtctttagagatagaggccatgacaag	CRISPR spacer
taacaacatagtctttagagatagaggccatgacaag	Protospacer
*************************************

3. spacer 5.6|3285362|37|NZ_CP012603|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 0, identity: 1.0

acatactaatttttgatccaactgttgttgtgttaat	CRISPR spacer
acatactaatttttgatccaactgttgttgtgttaat	Protospacer
*************************************

4. spacer 16.1|3289304|35|NZ_CP012603|CRISPRCasFinder matches to NZ_CP040842 (Leptospira weilii strain CUDO6 plasmid pDO6, complete sequence) position: , mismatch: 0, identity: 1.0

agttaatcaaaaagattctgagtattttagaagag	CRISPR spacer
agttaatcaaaaagattctgagtattttagaagag	Protospacer
***********************************

5. spacer 16.1|3289304|35|NZ_CP012603|CRISPRCasFinder matches to NZ_CP040845 (Leptospira weilii strain CUD13 plasmid pD13, complete sequence) position: , mismatch: 0, identity: 1.0

agttaatcaaaaagattctgagtattttagaagag	CRISPR spacer
agttaatcaaaaagattctgagtattttagaagag	Protospacer
***********************************

6. spacer 10.4|3287330|35|NZ_CP012603|CRISPRCasFinder matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 1, identity: 0.971

ccacgaaacagatacaaagccttctatttttccct	CRISPR spacer
ccacgagacagatacaaagccttctatttttccct	Protospacer
******.****************************

7. spacer 12.1|3287814|38|NZ_CP012603|CRISPRCasFinder matches to NZ_CP039286 (Leptospira interrogans strain FMAS_AW1 plasmid pLiSL3, complete sequence) position: , mismatch: 1, identity: 0.974

agcgtactaggtcgtgaatcacttactggggctgaaaa	CRISPR spacer
agcgtactaagtcgtgaatcacttactggggctgaaaa	Protospacer
*********.****************************

8. spacer 15.2|3288895|37|NZ_CP012603|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 1, identity: 0.973

gcaaattgagttttaggatttctgctacaatatcttt	CRISPR spacer
gcaaattgagctttaggatttctgctacaatatcttt	Protospacer
**********.**************************

9. spacer 7.1|3286324|35|NZ_CP012603|CRISPRCasFinder matches to NZ_CP006725 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence) position: , mismatch: 3, identity: 0.914

caacgtttcgcgggaccttgattccttcggagcga	CRISPR spacer
ccgtgtttcgcgggaccttgattccttcggagcga	Protospacer
* ..*******************************

10. spacer 7.1|3286324|35|NZ_CP012603|CRISPRCasFinder matches to NZ_CP039285 (Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence) position: , mismatch: 3, identity: 0.914

caacgtttcgcgggaccttgattccttcggagcga	CRISPR spacer
ccgtgtttcgcgggaccttgattccttcggagcga	Protospacer
* ..*******************************

11. spacer 5.2|3285072|36|NZ_CP012603|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039285 (Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence) position: , mismatch: 5, identity: 0.861

ttaaatcggaagcatgttgcgactcgatttcgaaat	CRISPR spacer
ttaaatcggaagcatgttgcgactcgattccgtggg	Protospacer
*****************************.** ..

12. spacer 5.2|3285072|36|NZ_CP012603|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006725 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence) position: , mismatch: 5, identity: 0.861

ttaaatcggaagcatgttgcgactcgatttcgaaat	CRISPR spacer
ttaaatcggaagcatgttgcgactcgattccgtggg	Protospacer
*****************************.** ..

13. spacer 5.10|3285651|35|NZ_CP012603|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 6, identity: 0.829

ttaacaaccatatctgtagtcttatatgcaatttt	CRISPR spacer
ttaacaaccatatctgtagtcttatattttgtata	Protospacer
*************************** . .* *

14. spacer 16.1|3289304|35|NZ_CP012603|CRISPRCasFinder matches to HQ633071 (Synechococcus phage S-SKS1 genomic sequence) position: , mismatch: 7, identity: 0.8

agttaatcaaaaagattctgagtattttagaagag	CRISPR spacer
atttaaatctaaagattctgaatatttttgaagag	Protospacer
* **** .  ***********.****** ******

15. spacer 16.1|3289304|35|NZ_CP012603|CRISPRCasFinder matches to NC_017791 (Deinococcus gobiensis I-0 plasmid P2, complete sequence) position: , mismatch: 8, identity: 0.771

agttaatcaaaaagattctgagtattttagaagag	CRISPR spacer
tttggtttaaaaagattcagagtattttagaggag	Protospacer
  * . *.********** ************.***

16. spacer 15.3|3288968|36|NZ_CP012603|CRISPRCasFinder,CRT,PILER-CR matches to MG675557 (Pseudoalteromonas phage Maelstrom, complete genome) position: , mismatch: 9, identity: 0.75

catttttgctcttccttaatattcattttgtttact	CRISPR spacer
tctttttgctcttcgttcatattcatttcatccaat	Protospacer
. ************ ** **********..*..* *

17. spacer 10.1|3287114|36|NZ_CP012603|CRISPRCasFinder matches to NC_011777 (Bacillus cereus AH820 plasmid pAH820_272, complete sequence) position: , mismatch: 10, identity: 0.722

------tgcgaaatagaagaacttttgatgtttgatataaag	CRISPR spacer
atcatttgt------gaataacttttgatgtttgatattaat	Protospacer
      **.      *** ******************* **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

614307 : 666360

uncultured_virus(20.0%)

transposase,holin,integrase,tRNA

attL 612264:612284|attR 620083:620103

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
612264:612284	attL	NA	NA	NA	NA
WP_000846379.1\|614307_615603_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_002188477.1\|615800_616547_+	hypothetical protein	NA	NA	NA	NA
WP_000817677.1\|616681_617659_+	DUF1016 family protein	A0A218ML12	uncultured_virus	7.9e-08	39.4
WP_060684555.1\|617791_619900_+	hypothetical protein	NA	NA	NA	NA
WP_002188342.1\|619914_620523_+	lipoprotein, tandem type	NA	NA	NA	NA
620083:620103	attR	NA	NA	NA	NA
WP_144421853.1\|621029_621299_-\|transposase	transposase	NA	NA	NA	NA
WP_000568654.1\|621587_621881_-\|transposase	transposase	NA	NA	NA	NA
WP_000569939.1\|621953_622508_+	hypothetical protein	NA	NA	NA	NA
WP_000019011.1\|623060_623672_-	DUF3365 domain-containing protein	NA	NA	NA	NA
WP_000014140.1\|623858_624608_+	YebC/PmpR family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_001257919.1\|625625_626141_+	crossover junction endodeoxyribonuclease RuvC	NA	NA	NA	NA
WP_000636526.1\|627603_627786_-	hypothetical protein	NA	NA	NA	NA
WP_002188329.1\|627791_630356_+	sulfatase-like hydrolase/transferase	NA	NA	NA	NA
WP_139343784.1\|630669_630894_-\|transposase	transposase family protein	S5WIN0	Leptospira_phage	4.3e-18	72.3
WP_002074720.1\|632243_632609_+\|transposase	transposase	NA	NA	NA	NA
WP_002188338.1\|633981_634422_-	host attachment protein	NA	NA	NA	NA
WP_060684557.1\|635126_635894_+	Fe-S cluster assembly ATPase SufC	A0A285PWH2	Cedratvirus	1.9e-09	30.1
WP_002188343.1\|635862_637098_+	Fe-S cluster assembly protein SufD	NA	NA	NA	NA
WP_000010050.1\|637094_637406_+	non-heme iron oxygenase ferredoxin subunit	NA	NA	NA	NA
WP_000010076.1\|637411_638653_+	cysteine desulfurase	Q2XUY6	environmental_halophage	2.2e-103	45.8
WP_000058819.1\|638636_639071_+	SUF system NifU family Fe-S cluster assembly protein	A0A2P1CJL8	Mycobacterium_phage	4.3e-14	37.8
WP_033108622.1\|639398_639722_+	DUF59 domain-containing protein	NA	NA	NA	NA
WP_000908611.1\|640199_640991_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000860665.1\|641547_642075_-	DUF1697 domain-containing protein	NA	NA	NA	NA
WP_000282990.1\|643287_645204_-	DUF1561 domain-containing protein	NA	NA	NA	NA
WP_060684637.1\|646128_647091_-	hypothetical protein	NA	NA	NA	NA
WP_060684558.1\|647247_648525_+	EAL domain-containing protein	NA	NA	NA	NA
WP_001146925.1\|649485_650445_-	hypothetical protein	NA	NA	NA	NA
WP_002108878.1\|650462_651764_-	hypothetical protein	NA	NA	NA	NA
WP_000777856.1\|651766_652291_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_000812417.1\|652577_653852_-	hypothetical protein	NA	NA	NA	NA
WP_060684559.1\|654933_656250_-	hypothetical protein	NA	NA	NA	NA
WP_000891135.1\|658330_659374_-\|tRNA	tRNA dihydrouridine(20/20a) synthase DusA	NA	NA	NA	NA
WP_001047901.1\|659535_660552_+	hypothetical protein	NA	NA	NA	NA
WP_002188340.1\|660551_662495_+\|tRNA	bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC	NA	NA	NA	NA
WP_000433097.1\|663446_664424_+	hypothetical protein	NA	NA	NA	NA
WP_000602007.1\|664607_665300_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_000121149.1\|665778_665967_+	hypothetical protein	NA	NA	NA	NA
WP_000581113.1\|665973_666360_+\|holin	phage holin family protein	NA	NA	NA	NA

DBSCAN-SWA_2

674140 : 688746

Leptospira_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_082269148.1\|674140_674233_+\|transposase	transposase	NA	NA	NA	NA
WP_112120681.1\|674257_674440_+	hypothetical protein	NA	NA	NA	NA
WP_000480703.1\|674439_675288_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	1.0e-40	34.2
WP_082280485.1\|675336_675477_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_000905909.1\|676003_676786_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	1.5e-113	79.2
WP_002074414.1\|676812_677076_-\|transposase	transposase	S5WIS5	Leptospira_phage	8.5e-10	85.4
WP_002188383.1\|678878_679922_-	tetraacyldisaccharide 4'-kinase	NA	NA	NA	NA
WP_000172205.1\|679945_681775_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.8e-56	33.0
WP_000348635.1\|681825_683385_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000010432.1\|683362_685771_-	penicillin-binding protein	NA	NA	NA	NA
WP_000717898.1\|686122_686923_-	DUF1835 domain-containing protein	NA	NA	NA	NA
WP_001971044.1\|687672_688746_-\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

3127459 : 3144583

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188275.1\|3127459_3134563_-	RHS repeat-associated core domain protein	S5VY91	Leptospira_phage	5.9e-278	32.2
WP_002188287.1\|3134998_3135883_+	hypothetical protein	S5VSU6	Leptospira_phage	5.8e-135	81.0
WP_002188281.1\|3135879_3137250_+	kelch repeat protein	S5VKK9	Leptospira_phage	6.3e-229	86.4
WP_002188291.1\|3137259_3137883_+	tetratricopeptide repeat protein	S5VKQ0	Leptospira_phage	8.2e-51	57.5
WP_002188267.1\|3138065_3139499_-	hypothetical protein	S5W9F7	Leptospira_phage	2.5e-167	66.9
WP_000818560.1\|3139968_3140598_-	DUF3102 domain-containing protein	Q9G092	Leptospira_phage	3.6e-14	42.7
WP_000691796.1\|3140581_3141334_-	AAA family ATPase	Q9G093	Leptospira_phage	3.0e-23	34.5
WP_000105514.1\|3141746_3142124_-	hypothetical protein	NA	NA	NA	NA
WP_060684611.1\|3143149_3144583_+	helix-turn-helix domain-containing protein	S5VKY0	Leptospira_phage	1.2e-126	58.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP012603

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection