CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Prophage number
NZ_CP010991	Pseudonocardia sp. EC080625-04 plasmid pFRP1-2, complete sequence	0 crisprs	NA	0	1
NZ_CP010989	Pseudonocardia sp. EC080625-04 chromosome, complete genome	6 crisprs	csa3,DEDDh,WYL,cas4,DinG,cas3	1	4
NZ_CP010990	Pseudonocardia sp. EC080625-04 plasmid pFRP1-1, complete sequence	0 crisprs	NA	0	3

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

63958 : 89428

Sinorhizobium_phage(50.0%)

integrase

attL 62319:62334|attR 92227:92242

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
62319:62334	attL	NA	NA	NA	NA
WP_060722615.1\|63958_64993_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_145982895.1\|65142_65448_-	hypothetical protein	NA	NA	NA	NA
WP_060722616.1\|65570_66311_-	RNA polymerase sigma factor	A0A0F6TH34	Sinorhizobium_phage	7.8e-08	32.5
WP_060722617.1\|66613_70546_+	PD40 domain-containing protein	NA	NA	NA	NA
WP_060722618.1\|70485_71880_-	hypothetical protein	NA	NA	NA	NA
WP_145982896.1\|73102_73357_+	hypothetical protein	NA	NA	NA	NA
WP_060722211.1\|74284_75562_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_168170503.1\|75666_78033_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_082399521.1\|78316_79261_+	MinD/ParA family protein	NA	NA	NA	NA
WP_145982669.1\|79281_79923_-	hypothetical protein	NA	NA	NA	NA
WP_060722621.1\|80034_80451_+	hypothetical protein	NA	NA	NA	NA
WP_060722622.1\|80450_81737_+	glycoside hydrolase family 16 protein	NA	NA	NA	NA
WP_060722623.1\|81804_84255_+	hypothetical protein	NA	NA	NA	NA
WP_060574667.1\|84190_85537_+\|integrase	tyrosine-type recombinase/integrase	A0A0M4RD74	Mycobacterium_phage	3.0e-05	31.0
WP_145982901.1\|85986_88125_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_082399315.1\|88414_89428_-\|integrase	site-specific integrase	NA	NA	NA	NA
92227:92242	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP010989

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP010989_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010989_1

493137-493217

Orphan

Consensus_repeat	Method
GCCCGGCGCTGGGGAGCGGCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010989_1

>merge|NZ_CP010989|1|493137-493217|CRISPRCasFinder
GCCCGGCGCTGGGGAGCGGCCGGTGCCGTGGAGGAATCCGGTACCGCCGTGCGGGGCCGACCGGCGCTGGGGAGCGGCCGG

>NZ_CP010989|1|1|493137-493217|CRISPRCasFinder
GCCCGGCGCTGGGGAGCGGCCGG	TGCCGTGGAGGAATCCGGTACCGCCGTGCGGGGCC
GACCGGCGCTGGGGAGCGGCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010989.1\|WP_060574866.1\|480082_481258_+\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NZ_CP010989.1\|WP_010235746.1\|481263_482151_+\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
NZ_CP010989.1\|WP_060574875.1\|502953_503787_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP010989.1\|WP_010234099.1\|501736_502069_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_060721837.1\|504419_507008_+\|bifunctional-FO-biosynthesis-protein-CofGH	unknown	unknown	gnl\|CDD\|236422
NZ_CP010989.1\|WP_010225768.1\|486506_488069_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NZ_CP010989.1\|WP_029239886.1\|497635_498487_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase	unknown	unknown	gnl\|CDD\|237637
NZ_CP010989.1\|WP_060576450.1\|485895_486510_+\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|235544
NZ_CP010989.1\|WP_060574865.1\|478793_479807_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224001
NZ_CP010989.1\|WP_082398787.1\|491284_492811_-\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349873
NZ_CP010989.1\|WP_060574874.1\|502111_502957_+\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197336
NZ_CP010989.1\|WP_060574871.1\|493306_496663_+\|error-prone-DNA-polymerase	unknown	unknown	gnl\|CDD\|235553
NZ_CP010989.1\|WP_060574868.1\|483956_485705_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NZ_CP010989.1\|WP_082398786.1\|489615_491262_+\|DNA-polymerase-Y-family-protein	unknown	unknown	gnl\|CDD\|176458
NZ_CP010989.1\|WP_060574872.1\|498521_498830_+\|DUF3017-domain-containing-protein	unknown	unknown	gnl\|CDD\|378602
NZ_CP010989.1\|WP_060574876.1\|503828_504338_+\|YbaK/EbsC-family-protein	unknown	unknown	gnl\|CDD\|239825
NZ_CP010989.1\|WP_060574873.1\|499255_501487_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|377178
NZ_CP010989.1\|WP_174521758.1\|488521_489619_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_145982526.1\|482304_483765_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP010989.1\|WP_033200406.1\|496744_497404_-\|membrane-protein	unknown	unknown	gnl\|CDD\|366504

Protein	Function_ID	Function_description	E-value
NZ_CP010989.1\|WP_060574866.1\|480082_481258_+\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NZ_CP010989.1\|WP_010235746.1\|481263_482151_+\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
NZ_CP010989.1\|WP_060574875.1\|502953_503787_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.06145e-34
NZ_CP010989.1\|WP_060721837.1\|504419_507008_+\|bifunctional-FO-biosynthesis-protein-CofGH	gnl\|CDD\|236422	PRK09234, fbiC, FO synthase; Reviewed.	0
NZ_CP010989.1\|WP_010225768.1\|486506_488069_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_CP010989.1\|WP_029239886.1\|497635_498487_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase	gnl\|CDD\|237637	PRK14193, PRK14193, bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional.	1.57247e-171
NZ_CP010989.1\|WP_060576450.1\|485895_486510_+\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|235544	PRK05647, purN, phosphoribosylglycinamide formyltransferase; Reviewed.	3.72396e-86
NZ_CP010989.1\|WP_060574865.1\|478793_479807_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	5.78635e-16
NZ_CP010989.1\|WP_082398787.1\|491284_492811_-\|M28-family-peptidase	gnl\|CDD\|349873	cd03876, M28_SGAP_like, M28 Zn-peptidase Streptomyces griseus aminopeptidase and similar proteins. Peptidase family M28; Streptomyces griseus Aminopeptidase (SGAP, Leucine aminopeptidase (LAP), aminopeptidase S, Mername-AA022 peptidase) subfamily. SGAP is a di-zinc exopeptidase with high preference towards large hydrophobic amino-terminal residues, with Leu being the most efficiently cleaved. It can accommodate all except Pro and Glu residues in the P1' position. It is a monomeric (30 kDa), calcium-activated and calcium-stabilized enzyme; its activation by calcium correlates with substrate specificity and it has thermal stability only in the presence of calcium. Although SGAP contains a calcium binding site, it is not conserved in many members of this subfamily. SGAP is present in the extracellular fluid of S. griseus cultures.	5.05348e-108
NZ_CP010989.1\|WP_060574874.1\|502111_502957_+\|exodeoxyribonuclease-III	gnl\|CDD\|197336	cd10281, Nape_like_AP-endo, Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Neisseria meningitides Nape and related proteins. These are Escherichia coli exonuclease III (ExoIII)-like AP endonucleases and belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiences. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity; for example, Neisseria meningitides Nape and NExo. Nape, found in this subfamily, is the dominant AP endonuclease. It exhibits strong AP endonuclease activity, and also exhibits 3'-5'exonuclease and 3'-deoxyribose phosphodiesterase activities.	5.52672e-110
NZ_CP010989.1\|WP_060574871.1\|493306_496663_+\|error-prone-DNA-polymerase	gnl\|CDD\|235553	PRK05672, dnaE2, error-prone DNA polymerase; Validated.	0
NZ_CP010989.1\|WP_060574868.1\|483956_485705_+\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	9.08062e-08
NZ_CP010989.1\|WP_082398786.1\|489615_491262_+\|DNA-polymerase-Y-family-protein	gnl\|CDD\|176458	cd03468, PolY_like, DNA Polymerase Y-family. Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.	1.49205e-44
NZ_CP010989.1\|WP_060574872.1\|498521_498830_+\|DUF3017-domain-containing-protein	gnl\|CDD\|378602	pfam11222, DUF3017, Protein of unknown function (DUF3017). This bacterial family of proteins with unknown function appear to be restricted to Actinobacteria.	1.89692e-13
NZ_CP010989.1\|WP_060574876.1\|503828_504338_+\|YbaK/EbsC-family-protein	gnl\|CDD\|239825	cd04333, ProX_deacylase, This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro) deacylase and also the cis-acting prolyl-tRNA synthetase-editing domain (ProRS-INS). While ProX and ProRS-INS hydrolyze misacylated Ala-tRNA(Pro), the E. coli YbaK hydrolyzes misacylated Cys-tRNA(Pro). A few CD members are N-terminal, YbaK-ProX-like domains of an uncharacterized protein with a C-terminal, predicted Fe-S protein domain.	1.03592e-53
NZ_CP010989.1\|WP_060574873.1\|499255_501487_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|377178	pfam03971, IDH, Monomeric isocitrate dehydrogenase. NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism, as it controls the carbon flux within the citric acid cycle and supplies the cell with 2-oxoglutarate EC:1.1.1.42 and NADPH for biosynthetic purposes.	0
NZ_CP010989.1\|WP_145982526.1\|482304_483765_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	2.09691e-07
NZ_CP010989.1\|WP_033200406.1\|496744_497404_-\|membrane-protein	gnl\|CDD\|366504	pfam01184, Grp1_Fun34_YaaH, GPR1/FUN34/yaaH family. The Ady2 protein is required for acetate in Saccharomyces cerevisiae, and is probably an acetate transporter. A homolog in Yarrowia lipolytica (GPR1) has a role in acetic acid sensitivity.	1.15881e-09

>NZ_CP010989.1|WP_082398787.1|491284_492811_-|M28-family-peptidase
MRTATTGTTPGGSTRRRVAGRRLARVLGAGVAVAALAACANVPAGPGTAVLPPGAAGTDGATPQSDPGLPARLAGAVSGDAAYAHLEQLQKIADANDGNRAIGTPGYDASVDYVSRTLREAGYDVQTPSFDVRTFTAGDARLTVAGAPVPTEVLSFSPATPPGGLTAPLSVRPRAPQDPSPGCEAEDYAEMPAGAIAVVERGVCEFGQKSRLAGAAGAVAVIVTNTEDAALPATLGETPGVVPTAAVQRTAGAALRDGQQATLLLDTTIQQQTSRNVIAETSTGDPDRVVMAGAHLDSVPEGAGINDNGSGSAALLDVAQKLGAAPPAGQKVRFAWWGAEEIGLVGATRYVESLSQQDRAKVGLYLNFDMVASPNAAYLVYDGDDSDRLGGEAGPPGSGAAEQVLTESLVAAGVQGPEGTAFDGRSDYGPFIEAGIPAGGLFTGAEERKTPEQAQKWGGTPGQSYDACYHTPCDRLTNIDRVALDRNVTAMGNAIGRFAVDMTGVPAR
>NZ_CP010989.1|WP_082398786.1|489615_491262_+|DNA-polymerase-Y-family-protein
MSAAGSAADVADPAARGPGGAGARVPDPRVLAVWSPDWPVTAAARAAHVPAHRPAAVFHANRVLACSAIARRHGVRRGLRRREAQARCPDLAVLAPDPGRDARLFEPVAAAVEGLAPGVEVVRPGLLVLPARGPVGWFGGEREAIERLIDQVALHAATECQIGVADGMFAAELAARRGRGVPSGRSAEFLAPLEVAELDRDPETDRSALIDLLRRLGLRSLGAFGALTEADVASRFGADAVAAYRLARGLDPRPPVRRVPPEELAAAIELDPPVDRVDAAAFAARGLATRLHEALAGHGLACTRLGVHARTDSGEDLLRVWRCAEPLTPAGTVDRVRWQLDSWLGRGGSGTLVALRLTPEDTVVAGALQRGLWGDVGENDERAGRALVRVQALLGPESVVTAVPTGGRDPGERVRLVPWGEERVVEAPAPPRSGVPKDPPASWPGRLPAPSPATVLPDPAPVRLLDADGSEVSLPAPDLLDGDPHRISGGGGPDREIAGWAGPWPVHTRWWAPDAPGPTARLQVALADGAALLLVHRGTRWEVAGVYD
>NZ_CP010989.1|WP_174521758.1|488521_489619_+|hypothetical-protein
MIGSAPDGAGEPGGGPEPRYRPETGEPHPGPEEAAGPVIGAGVRSAGTDGEPVPAGRAGSGAGPRAGLAGSRDPGSGREPLHGARGPVGGPVSDRLARARQVLHRVETRADVERSRPVARPGCGATAADAGPARTTGTADPDDAVLLPVPGPLAGLLPAGGLRRGSTVAVGAGAGAGSLLFALLAAASAEGCWAGVVGRPGLGAAAAAEAGVRLDRLALVPDPGADLVGVTAALLDGLDLVVVAGPERAGLRAGDRQRLTARARQRGAVLLALGSWPGADLRLHCERPRWEGVGRGEGRLRYRRIEVRASGRGIGPAGRGAEVLLPGPGGAVLAAPEQVPAGSRPTPVAAPGQVLPGRPVVQVAG
>NZ_CP010989.1|WP_010225768.1|486506_488069_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MSERRPVRRALISVYDKAGLLDLATGLHAAGVEIVSTGSTAQRIADAGVPVTPVEEVTGFPECFDGRVKTLHPRVHAGLLADTRKDEHVVQLEQLNIAPFDLLVSNLYPFRETVASGASRDEAVEQIDIGGPAMVRASAKNHESVAVVVEPSRYEWVLEQVAAGGFVVADRRRLAADAFRHTAAYDVSVATWMGEQFPAGDGTEATPEWFGATWTRERALRYGENPHQAAALYADGGATGLAGAEQLHGKEMSYNNYVDADAAWRAAHDHGDRPTVAVIKHANPCGIAVGADVAEAHRKAHATDPVSAFGGVVAVNGEVSVAMAEQVAEIFTEVVVAPSYADGALEVLQRKKNVRLLRIPGEVARGGTELRPISGGVLVQQRDLVDAAGDDPAAWKLVTGDPASPELLADLAFAWRACRAVKSNAILLAHDGAAVGVGMGQVNRVDAAKLAVERAGDRVRGAVVASDAFFPFPDGLEVLLDAGVAAVVQPGGSVRDEQVVAACAKAGVPMYLTGTRHFAH
>NZ_CP010989.1|WP_060576450.1|485895_486510_+|phosphoribosylglycinamide-formyltransferase
MHAQEQAGPFRVVVLVSGAGTLLQALLDASPAGPSGYRVVAVGADRPGAAGLDRAREAALPTFVERVADHPDRDAWNAALAAAVVAHRPDVVVGAGFMKLVAPAFLDAIGCPMLNTHPALLPAFPGAHAVRDALAAGVRTTGATVHEVDAGLDTGPVLAQVEVPVLPTDDETVLHERIKTEERRLLVETVLRLAAAGRTHEVSQ
>NZ_CP010989.1|WP_060574868.1|483956_485705_+|hypothetical-protein
MSTPPRPARGRPASRSRPSGPGASRSRDDAAARDGRGGVAERERPRATTRRPAPDRRPGDGNGLDRLRILLASTMGAVLAGYTLLVPVAALIAGTGGVPVTADAALATAVPMWLAAHQIPIALDGRPLGVLPLLPTLVIVAVVAWFSRWAVRRLGGRVRHDAGAVVAAQAGAAAAVAVLAGALLPKEMAVTAPWASLLGAGLIGGAAAGAGVVHACGMPAAWKRVLAGWPGAALAGVRVAATSLLLTGALVLTGALLLTATAVSDAAARLGPGIGAGFGVLVLAVGYLPNALVGAVSWMLGAGVSVGVATSGPLLAEPGPLPAFPLTALLPVTTVPPAAPLVLLLPVLAGVLTGLACRRALADGAPMAERAVAPATAAVVVATGAGALATVAGGPLAGGPYDPVSFHPGAVLGAVLLLVGLPALLTCAGPELARHVPMGGPAGGRAGRAPGTGSRAVRRERSSTVADLVEGRRRSGASSRSGGSGGRDGRVRREGRRDPAGAVGDGAARVGDAPHDDPDHDHPDHDHPDHEGPGDPGTADHDGPADHADHDGPDHDDPGHDPGPDRDGPRRGSRGDDRDPTG
>NZ_CP010989.1|WP_145982526.1|482304_483765_+|hypothetical-protein
MSSNQPPSPGAGPDDAVTPPAGTVRLAVLGGAAAALLVLVTAFFGLPPAAAYALAMVVAGGIAGGLSLLPGTGRVLVAGTVLSGTGFLTLLFLFTASGSPVAAGAVGWVAVAFALLSVAGLFYGQLLLSGVLAAPAPRAARPAHAPSNEPPWATPGLPQQPGHGRPGQAGGYDAYGPGRGGHPGAHEGPGQYAQQPGHYGAQHGQYAAEPGQYGGQPGQYGGQPGQYGIQPGQFTQQPGQYGAQAGQPGAQPGAPAGQYGIPAADQYGGQPGQYGGQPGQYGGQAGQYGQQPGQYGEPGQYGQQPQGAGQAVPGSYAPSTAASGGAFSGVAYGERAADPGRGHGGGAVPAVPGQQAAGADAPGAPGQGGPAGPAEFGQQGPAEQPAQGAAQHTPDEVAGQHLPGEPAVGQTAHGVPGAGQNGPGGQAVDPNAPGVPAAGARGQSGTPEQQASGEQSPGHDPARQTPVTDDDATRAFRAGGGRPPSS
>NZ_CP010989.1|WP_010235746.1|481263_482151_+|succinate--CoA-ligase-subunit-alpha
MSIFLNENSKVIVQGITGGEGTKHATKMIASGTNIVGGVNARKAGTTHTVGDKDVTVYGTVEEAMKETGADVSVLFVPPKFAKDAVIEAIDAEIPLAVVITEGIPVHDSAYFWAHAVAKGNKTRIIGPNCPGIISPGKSNAGIIPANIAGPGKIGLVSKSGTLTYQMMFELREFGFSTAIGIGGDPVIGTTHIDALEAFEADPDTEAIVMIGEIGGDAEERAADFIKANVTKPVAGYVAGFTAPEGKTMGHAGAIVSGSAGTAQAKKEALEAAGVKVGKTPSETAALMKEILSAK
>NZ_CP010989.1|WP_060574866.1|480082_481258_+|ADP-forming-succinate--CoA-ligase-subunit-beta
MDLYEYQAKDLFAAHGVPVLPGKTVDNAADAAAAASELGTAVVVKAQVKTGGRGKAGGVKLAQSADEAKEKAEAILGLDIKGHTVHQVLVTEASDISEEYYFSFLLDRSNRTFLAMCSAEGGMEIEELAVERPEALARIAIDPIAGVDKAKADEIVAAGKIPAAVADEAANVIVKLWETFVAEDATLVEVNPLVRDPQDKVIALDGKVTLDENAAFRHEAHAELVDERTENPLEAKAKAKGLNYVKLDGGQVGVIGNGAGLVMSTLDVVAYAGEAHGGVKPANFLDIGGGASAQVMADGLDVILGDDEVKSVFVNVFGGITACDAVANGIVEALKILGDDATKPLVVRLDGNNVEEGRKILADANHPLVTVVGTMDDAAAKAAELANAAGA
>NZ_CP010989.1|WP_060574865.1|478793_479807_-|alpha/beta-fold-hydrolase
MATSLPGWRRLRAIASGATDLASDLGQATGYAVRTFTSPAGLRGLAVEWAWLSAHLALYPIGLAEETVRAHGHWRTDTLPPVKRSLVVADPAAAGTPILLIHGIMDNRSVFTVFAHALRRRGFGTVHAINYSLLTGDLRSAAHELRGHVERLREATGSDKVHIVGHSLGGVVARYYVQRMGGDDVVDTLVTLGSPHSGSNLARLAPTALCRQLRPGSEVLAELDAPAPGCRTRFLVAWSRMDEVVVPQRNARLQHPDLDVQELRLDDVGHLSLPIDRRTVHWVASTLARGEVERREHDAVRDRRLRGSLRPAGRHAVDAELDGTGGGVPGVPGAPAS
>NZ_CP010989.1|WP_060574871.1|493306_496663_+|error-prone-DNA-polymerase
MGWQNPDVPWSELEGALSGRSVRDGSSLRGGPEADGGDAPAWSAHRGPYEPPAGLRAGAATVPYAELHCHSHFSFLDGASAPEELVERAAELGLEAIALTDHDGMYGVVRFAEAARALGIRTVFGAELSLGLSAPQNGVADPEGEHLLLLARGPDGYRALCRTISTAQMRGGEKGRPVYDLDEVVADTAGRVVVLTGCRKGAVRRALDRHGPGAAAAALERLAERFGRENVRVELTVHGEPCDTERNDALAALAAAAGVATVATTAAHYAAPDRAPLAATVAAVRARRSLDEIDPWLPAAGTAHLRSGREMTRRFEDRHPGAVARAAGLGRELAFELHLVAPDLPPFDVPEGETEASWLRALTERGRLQRYGSHDENPFAAYTVERELAIIEEKNFPGYFLIVHDIVDFCRREDIFCQGRGSAANSAVCYALGITNVDAVRHGLLFERFLSPDRDGYPDIDLDIESGRREEAIQYVYRRYGRLFAAQVANVITYRPRSAVRDTARALGFSPGQQDAWSKRVERWHALEASELGTGGEQTLQMPPLLLDLAGQLMGAPRHLGIHSGGMVICDRPVSEVVPVEWARMEDRTVVQWDKEDCAAAGLVKFDLLGLGMLTALHLMADLVERNDGTRIELHRIGESDPEVYAMLSRADSVGVFQVESRAQMATLPRLRPREFYDLVVEVALIRPGPIQGGSVHPYIRRRNRIDDWEHDHPLLKPALDKTLGIPLFQEQMIQIAVDVAGFSAAEADELRRAMGAKRSTEKMERLRGRFFDGMAANGITGELAETIFTKMLAFANFGFPESHSISFAALVYYSAWFKLYHPAAFCAALLNAQPMGFYSPQSLVADARRHGVRVRRPDVNEGRADAILQPDPDSTGGWAVRLGLSGIRTIGTDLAGAVDAVRASAGPFADLPDLARRVRLTGPQAEALATAGAFGCFGVERREALWAAGVVAGVRPEHLPGTAVGFDAPALPGMTDAELTVSDVWATGVSPDSHPVQHLRGKLDGLGAVRIDRLDDVGRRAGPDAPPRVLVGGLVTHRQRPATARGVTFVNLEDESGMLNVTCSEGLWARYRSVALGSAALLVRGRLERSPEGVLNLLADRLQRMPLAVPVQSRDFR
>NZ_CP010989.1|WP_033200406.1|496744_497404_-|membrane-protein
MSVESETAGAQTAAPPAAAAPAANPALMGLICFLPSGITLGLWFVGYLDTTALPGGMIPIVTFSAGLFLLLAAMSALRVGDSVTAAIFGVFSAFWTSFGVLLMALNNGWIIDAGTGGPLATDQIGSIQSAYLLSFTLVFILLTLATLRLPLMFTIGFVLVDITFVLAYLGVTAGNAGLFPIAGITTFGFCIVFAYILFDAFGQTLGGRAMAMGNPLVKS
>NZ_CP010989.1|WP_029239886.1|497635_498487_+|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase
MSATVMDGKATLAELLEDLRVRVEKLTAAGRTPGLGTVLVGDDPGSHAYVRGKHRDCAKVGITSLQRELPADASQAQVDDTIDELNADPSCTGFIVQLPLPAGLDSGAALERVDPLKDADGLHPVNLGRLVLGEPGPLPCTPRGIVALCRRFGVELDGARVVVVGRGVTVGRPLGLLLTRRSENATVTLCHTGTTDLTAHLREADVVVAAAGRAGLITADQVKPGAAVLDVGVTRTDLGLVGDVAPEVAEVAGLLAPMPGGVGPMTRGMLLTNVVEAAERAAG
>NZ_CP010989.1|WP_060574872.1|498521_498830_+|DUF3017-domain-containing-protein
MATTRSGFGLRARLRAYWPLLTVLAIALIGLQRVATEHWREGSAALGVAMLVAAVLRVVLPPDRVGLLAVRGRYVDALVYGGFGLAVLALALTITRGSLTVS
>NZ_CP010989.1|WP_060574873.1|499255_501487_-|NADP-dependent-isocitrate-dehydrogenase
MKLIYTYTDEAPALATHSFLPVIEAFAGQAGVDVETRDISLAARILAKFPDRLTDAQRVPDSLAELGELAKTPDANIIKLPNISASIPQLKAAIKELQGAGYDVPDYPEDPRTDDEKAARAAYDAVKGSAVNPVLREGNSDRRAPASVKNFARKHPHSMGAWNSDSKSHVATMSDGDFRHSEKSFTVAADGALRIEHVAADGTVTVLKDAVKVLAGEVIDGSVMRREALQAFLAEQVADAKAKGVLFSVHLKATMMKVSDPKIFGHAVRAYFADVFAAYGDDLASVGADPDDGLASVLSALEKLPADKREAIEKAITAAYETGPALAQVDSSRGITNLHVPSDVIIDASMPAAIRSSGQMWNADDATQDAKFVIPDSSYADLYDETVKHCIANGAFDPTTMGTVPNVGLMAQKAEEYGSHDKTFEIVSAGTVRVVDAASGEEKLSHEVAEGDIWRACQTKDAPIRNWVGLAVDRARATGSPAVFWLDSSRAHDAQLIAKVETYLGELDTDGLTIEILPVGEATRYTLERARKGEDTISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQLQKENHLRWDSLGEFLALAVSLEMLASKSPDPLRAKLLGQALDDATGLLLENGKSPSRKVNELDNRGSHFYVAWYWAQALAEQTEDPELAAVFAPLAKALGEQEETILGELNGAQGDPVDLGGYYYVDRAKADSVMRPSATLNAAIDGFAGRS
>NZ_CP010989.1|WP_010234099.1|501736_502069_+|hypothetical-protein
MAKVKIPGLTRTTFLSGWPLVALIAVGLTAVALLYGGATDEFGSTCRVTVQAAEVTVRAAPAASAQPVDTLTRGEEVGAETIVDSGFRKLTGGDRWVPSNSVAATAGSVC
>NZ_CP010989.1|WP_060574874.1|502111_502957_+|exodeoxyribonuclease-III
MPPPVRALATANVNGVRAATGKGLLDWLAVTDVDAVCLQEVRARPEELPAALTDALAAAGWHLRLAPCETAKGRNGVAVLSRSEPEAVRIGFGDPATDLDGRYLEVDLPGDLTVASLYLPKGVAGTDKQDAKDAFLKTFGDHLRTAFARCAATGREMVVAGDWNIAPTEQDLRNWRNNQRNSGFLPHEREWFAGLLEHGWTDVVRALHPGTDGPYSWWTYRGRAFDNDVGWRIDHLLTTPGLAAAAHEAVVERAPSHDTRWSDHAPVVVRLGPGAPAGGTE
>NZ_CP010989.1|WP_060574875.1|502953_503787_+|protein-kinase
MIESRVVGGRYLLLDELDRRGFGPSRRAEDRITGRTVAVTEIVMPADGAARQRLLAEVRAAGRLRHPGVVGVLDLITDRAADGGMREYLVTEHPDARPLGRLVAGDDPPSLRAVAGIGREVLAALRDVHAGAGTHGGLDPDCVLITPDGRALVTDVGLSRAVGPRAAGADTGAFTAPERDGGTGDTPAADLWSLGAVLHHAGGREAAPGSPLAQAITGLTAADPAERLGPDDADALLGRAAGPRGSGGDLGRNRWILLVVAALLAVAVVAMLLWVVR
>NZ_CP010989.1|WP_060574876.1|503828_504338_+|YbaK/EbsC-family-protein
MSETTGAAEHPADHPRVASVKESLRRAGADPASIAGLALLPDAVTTAAAAAAALDVEVGQIANSLVFDAGGEPLLVLTSGRHRVDTDRVAALLGVAVGRADKEFVRTATGQVIGGVAPVGHPAPLRTLVDVALDDYDRVWAAGGVARSVFPTTFAELVAVTGGTAAEVA
>NZ_CP010989.1|WP_060721837.1|504419_507008_+|bifunctional-FO-biosynthesis-protein-CofGH
MADTPAAPVPAEAAPSDSALRRALRRVRDGSTLDVTEAAVLLAARGEHLDELLSHAGRVRDAGLVEEGRPGVVTYSRNVFIPLTRLCRDRCHYCTFATVPHRLDSMFLERDEVVEIARQGAAQGCKEALFTLGDRPEERWPQAREWLEARGYDSTLDYVRACAIAVLEETGLLPHLNPGVMSWEEITRLKPVAASMGMMLETTSQRLFEKGGPHFGSPDKEPAVRVRALADAGRVGVPFTTGILIGIGENRTERAESLFAIRSAARQHGHVQEVIVQNFRAKPDTAMANDPDADLDDLAATIAVSRLVLGPKVRLQAPPNLVGDEQALMLRAGIDDWGGVSPVTVDHVSPEMPWPAVDELARVTAEEGFELRERLTAYPKYVRAGSPWIDTRLHGHVAALATADGLADPGAVVQGLPWQEPDGGFESTGRTDLHTAVDTEGRTDDRRSDFGSVYGDWDEVAAELESQRARAPERLAGDVKAGLELAASDPAALLDPANEAAAMAVLTGEGPALRELTRLADDVRRQVNGDDVTYVVNRNINFSNVCYVGCRFCAFAQRERDADAFRLSLDEIAQRAAEAARDGATEVCVQGGIDPQLPVSFYADLVRAVHEAVPGMHVHAFSPMEIVSAAAKAGVSIREWLSELKAAGLGSIPGTAAEILDDEVRWVLTKGKLPASQWIEVVSTAHELGIPSSSTMMYGHVDEPRHWLGHLRTLASVQDRTGGFTEFVPLPFVHHNAPIYLAGIARPGPTERDNRAVHAFARLALHGRIDHVQVSWVKLGDELAGQVLNGGADDMGGTLMEETISRMAGSENGSERSVEELTEIAHAAGRPVRQRTTTYRGEPSVLTPARPSGPRMLPLAPA

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Crispr_ID: NZ_CP010989_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010989_2

745427-745513

Orphan

Consensus_repeat	Method
GGGCGTCACGCACCCCGTCGCCGTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010989_2

>merge|NZ_CP010989|2|745427-745513|CRISPRCasFinder
CTGCCCGCCGCACCCCGTCCCCGCGCGCCGCACCCCGTGGCGGGCGTCACGCACCCCGTCGCCGTGCCGCGCACCCCGTCGCCGCGC

>NZ_CP010989|2|2|745427-745513|CRISPRCasFinder
CTGCCCGCCGCACCCCGTCCCCGCGC	GCCGCACCCCGTGGCGGGCGTCACGCACCCCGTCG
CCGTGCCGCGCACCCCGTCGCCGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010989.1\|WP_082398805.1\|748776_750009_-\|GAF-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP010989.1\|WP_060574974.1\|753044_753704_+\|endonuclease-NucS	unknown	unknown	gnl\|CDD\|235114
NZ_CP010989.1\|WP_060574975.1\|753717_754140_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_010228021.1\|747321_748752_-\|form-I-ribulose-bisphosphate-carboxylase-large-subunit	unknown	unknown	gnl\|CDD\|173977
NZ_CP010989.1\|WP_060576472.1\|752430_752937_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239516
NZ_CP010989.1\|WP_060576469.1\|744410_745277_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176112
NZ_CP010989.1\|WP_010242591.1\|738360_739098_-\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238017
NZ_CP010989.1\|WP_060574973.1\|751717_752479_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319830
NZ_CP010989.1\|WP_082398802.1\|739113_740184_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179385
NZ_CP010989.1\|WP_010242595.1\|740219_741110_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270223
NZ_CP010989.1\|WP_060574968.1\|734404_736423_+\|protein-meaA	unknown	unknown	gnl\|CDD\|239653
NZ_CP010989.1\|WP_060574972.1\|742775_744008_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP010989.1\|WP_010224404.1\|733853_734192_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_060574969.1\|736441_738364_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP010989.1\|WP_082398801.1\|732994_733846_+\|DUF1206-domain-containing-protein	unknown	unknown	gnl\|CDD\|377695
NZ_CP010989.1\|WP_010228026.1\|750005_750668_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP010989.1\|WP_010228028.1\|750776_751721_+\|phosphoribulokinase	unknown	unknown	gnl\|CDD\|180975
NZ_CP010989.1\|WP_082398804.1\|745824_746862_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|200217
NZ_CP010989.1\|WP_060574970.1\|741134_741908_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|181249
NZ_CP010989.1\|WP_010228019.1\|746848_747307_-\|ribulose-bisphosphate-carboxylase-small-subunit	unknown	unknown	gnl\|CDD\|177052

Protein	Function_ID	Function_description	E-value
NZ_CP010989.1\|WP_082398805.1\|748776_750009_-\|GAF-domain-containing-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.57233e-54
NZ_CP010989.1\|WP_060574974.1\|753044_753704_+\|endonuclease-NucS	gnl\|CDD\|235114	PRK03298, PRK03298, endonuclease NucS.	2.20877e-176
NZ_CP010989.1\|WP_060576469.1\|744410_745277_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176112	cd08420, PBP2_CysL_like, C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold. CysL, also known as YwfK, is a regular of sulfur metabolism in Bacillus subtilis. Sulfur is required for the synthesis of proteins and essential cofactors in all living organism. Sulfur can be assimilated either from inorganic sources (sulfate and thiosulfate), or from organic sources (sulfate esters, sulfamates, and sulfonates). CysL activates the transcription of the cysJI operon encoding sulfite reductase, which reduces sulfite to sulfide. Both cysL mutant and cysJI mutant are unable to grow using sulfate or sulfite as the sulfur source. Like other LysR-type regulators, CysL also negatively regulates its own transcription. In Escherichia coli, three LysR-type activators are involved in the regulation of sulfur metabolism: CysB, Cbl and MetR. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.73289e-41
NZ_CP010989.1\|WP_010228021.1\|747321_748752_-\|form-I-ribulose-bisphosphate-carboxylase-large-subunit	gnl\|CDD\|173977	cd08212, RuBisCO_large_I, Ribulose bisphosphate carboxylase large chain, Form I. Ribulose bisphosphate carboxylase (Rubisco) plays an important role in the Calvin reductive pentose phosphate pathway. It catalyzes the primary CO2 fixation step. Rubisco is activated by carbamylation of an active site lysine, stabilized by a divalent cation, which then catalyzes the proton abstraction from the substrate ribulose 1,5 bisphosphate (RuBP) and leads to the formation of two molecules of 3-phosphoglycerate. Members of the Rubisco family can be divided into 4 subgroups, Form I-IV , which differ in their taxonomic distribution and subunit composition. Form I is the most abundant class, present in plants, algae, and bacteria, and forms large complexes composed of 8 large and 8 small subunits.	0
NZ_CP010989.1\|WP_060576472.1\|752430_752937_-\|NUDIX-hydrolase	gnl\|CDD\|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	1.80236e-38
NZ_CP010989.1\|WP_010242591.1\|738360_739098_-\|FHA-domain-containing-protein	gnl\|CDD\|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	0.000176264
NZ_CP010989.1\|WP_082398801.1\|732994_733846_+\|DUF1206-domain-containing-protein	gnl\|CDD\|377695	pfam06724, DUF1206, Domain of Unknown Function (DUF1206). This region consists of two a pair of transmembrane helices and occurs three times in each of the family member proteins.	2.8489e-10
NZ_CP010989.1\|WP_060574973.1\|751717_752479_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319830	cd07528, HAD_CbbY-like, subfamily of beta-phosphoglucomutase-like family, similar to Rhodobacter sphaeroides xylulose-1,5-bisphosphate phosphatase CbbY. This family includes Rhodobacter sphaeroides and Arabidopsis thaliana xylulose-1,5-bisphosphate phosphatase CbbY which convert xylulose-1,5-bisphosphate (a potent inhibitor of Ribulose-1,5-bisphosphate carboxylase/oxygenase, Rubisco), to the non-inhibitory compound xylulose-5-phosphate. It belongs to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), Saccharomyces cerevisiae phosphatases GPP1 and GPP2 that dephosphorylate DL-glycerol-3-phosphate and DOG1 and DOG2 that dephosphorylate 2-deoxyglucose-6-phosphate, and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.72931e-54
NZ_CP010989.1\|WP_082398802.1\|739113_740184_-\|hypothetical-protein	gnl\|CDD\|179385	PRK02224, PRK02224, DNA double-strand break repair Rad50 ATPase.	0.000122533
NZ_CP010989.1\|WP_010242595.1\|740219_741110_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270223	cd01002, PBP2_Ehub_like, Substrate binding domain of ectoine/hydroxyectoine specific ABC transport system; the type 2 periplasmic binding protein fold. This family represents the periplasmic substrate-binding component of ABC transport systems that involved in uptake of osmoprotectants (also termed compatible solutes) such as ectoine and hydroxyectoine. To counteract the efflux of water, bacteria and archaea accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.39761e-69
NZ_CP010989.1\|WP_060574968.1\|734404_736423_+\|protein-meaA	gnl\|CDD\|239653	cd03681, MM_CoA_mutase_MeaA, Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, MeaA-like subfamily; contains various methylmalonyl coenzyme A (CoA) mutase (MCM)-like proteins similar to the Streptomyces cinnamonensis MeaA, Methylobacterium extorquens MeaA and Streptomyces collinus B12-dependent mutase. Members of this subfamily contain an N-terminal MCM domain and a C-terminal coenzyme B12 binding domain. S. cinnamonensis MeaA is a putative B12-dependent mutase which provides methylmalonyl-CoA precursors for the biosynthesis of the monensin polyketide via an unknown pathway. S. collinus B12-dependent mutase may be involved in a pathway for acetate assimilation.	0
NZ_CP010989.1\|WP_060574972.1\|742775_744008_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	7.52338e-94
NZ_CP010989.1\|WP_060574969.1\|736441_738364_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.32722e-86
NZ_CP010989.1\|WP_010228026.1\|750005_750668_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	8.7726e-56
NZ_CP010989.1\|WP_010228028.1\|750776_751721_+\|phosphoribulokinase	gnl\|CDD\|180975	PRK07429, PRK07429, phosphoribulokinase; Provisional.	7.00396e-132
NZ_CP010989.1\|WP_082398804.1\|745824_746862_-\|AAA-family-ATPase	gnl\|CDD\|200217	TIGR02880, Protein_CbxX_chromosomal, probable Rubsico expression protein CbbX. Proteins in this family are now designated CbbX. Some previously were CfxQ (carbon fixation Q). Its gene is often found immmediately downstream of the Rubisco large and small chain genes, and it is suggested to be necessary for Rubisco expression. CbbX has been shown to be necessary for photoautotrophic growth. This protein belongs to the larger family of pfam00004, ATPase family Associated with various cellular Activities. Within that larger family, members of this family are most closely related to the stage V sporulation protein K, or SpoVK, in endospore-forming bacteria such as Bacillus subtilis.	5.86039e-147
NZ_CP010989.1\|WP_060574970.1\|741134_741908_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|181249	PRK08139, PRK08139, enoyl-CoA hydratase; Validated.	2.03552e-87
NZ_CP010989.1\|WP_010228019.1\|746848_747307_-\|ribulose-bisphosphate-carboxylase-small-subunit	gnl\|CDD\|177052	CHL00130, rbcS, ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit; Reviewed.	2.13961e-77

>NZ_CP010989.1|WP_060576469.1|744410_745277_-|LysR-family-transcriptional-regulator
MRAFVALADQGSVRGAAARLVVTESTVSAAVRALAEEVGVPLVERDGRGVRLTPAGHRYAGYARRVLGLLEEGAAAARGEADPEHGRVRLAAVTTAGEHLLPDLLAGFRDRHPGVTLEVDVAPSDRVWPMLAHHEVDVAVAGRPPAAATGPGASGPPLVRAVRENTLVVVGAQAAEHDPARATWLLREPGSGTRATQEALLADLGVDPPRLLLGSHGATVAAARAGLGITLVSRDAVRRFLADGELTELAVPGTPLDRPWHVVTHPDATASTALLLAHVLATAPWHAR
>NZ_CP010989.1|WP_060574972.1|742775_744008_+|cytochrome-P450
MTASTEPRDLLSPDLTADPYAAYGRMREEAPAVTVTMMGTPPAVMVTRHDDVRTVLTDPRFVTDVELVGGAESMREAMFEKLGVPDDLAGYLLRNILTTDGAEHARLRKLVSRAFTVKRVQALRPRVEEITARLLDRIGDAGRVDLVETFGYPLPITVICELVGVPDGEREQWHEWGRVLASMDPQRVPAVLRAAVDHVHALVDARRAEPADDLISALVAAQDDDGDRLTDREMVTMIFALVMAGHETTAHLISNGALALLTHPDQLAVLRERPELWPQAVDELMRFRGPVQFTQFRYPTEDVELGGVAIPAGTPVIAGLLPANHDPRAYDRPDELDVGRDTGRGDGHLGFGRGAHYCLGAALARQEGEVALRMLFDRFPSLALDAPAAEILWVPRPGFSRVGELPVRVS
>NZ_CP010989.1|WP_060574970.1|741134_741908_-|enoyl-CoA-hydratase/isomerase-family-protein
MSDYEHLLVKQDGDTVRITMNRPQRRNSLTEGHLRELLDAFESAGRTDATGIVLAGEGKAFSSGHDFGDVADRDLAGVRELLRLCTTVMRTVQEVPQVVVARVHATAWAAGCQLVASCDLAVAAESASFALPGGKGGWFCHTPAVPVARTVGRKRLMELALTGDAIDAATAADWGLVNYAVPDDELDTRVDELLARATRGSRLSKAVGKQTLYAQLDRPEADAYAIATEVMASMSQSGGAREGMASFLGKRAPVWPD
>NZ_CP010989.1|WP_010242595.1|740219_741110_-|transporter-substrate-binding-domain-containing-protein
MSDPSLLSRRRLFGAAAALGGAALLAGCGRESGDALTRLRAGGDVVVGLSGERPFGFTDGSGRPTGESPEVARAVVGEIGGGGLVAVQLAFDQLVPALLDGRFDMIAVGLTVTPLRCQQVAFSRPDYIARTGLLVPTGNPLGVATLGGVRRSGATLGVLRSSAEQEYAYAARIPNEKIVTFDSQGALVRGIARQEAQVGALTRISLQDEVRRNAGIGLEVTGGFEPEVNGRPVVGAGAFAFRPADTGFREEFDRGLTALQESGRWLEAARPFGFTEENVPPRGLTIDDLCARTPES
>NZ_CP010989.1|WP_082398802.1|739113_740184_-|hypothetical-protein
MSLRIAGIPVPGPSDLLSGAASVVDRTGELAETVAGLPSRAGELLDEVGSLVGRIGTIATRAEALLDRVDGVVDRAEDLIGTVGSVAAEATDVVARVRPVADRADELVARVSTVADDADSLVERVTGVAENADGLVRKVTTVADDADGLVRRVTTVAENADGLVQKVTTVSEDASGLVRRVTTVSERADGLVEQVSAVAGNAEGLVARVDAVAGNADGLITTVTTVSDRAGDLITQVERVTGSATTVVDQASGISDRAGELVDLYAPLARRAAPLATKFLDELSEDEVHAAIRLVDQLPVLTEHLEDDILPILATLDRVGPDVHELLDVLKEVRQAIIGIPGFKLLSRRGGEKDDS
>NZ_CP010989.1|WP_010242591.1|738360_739098_-|FHA-domain-containing-protein
MQQRPSAEHTLFVQTLAGSATFGPKEGREVLFGRNRPLVHLTLGEDDPQVSREHGRLRFTGGRWWLSNSGRTGIRFPAGTELRPGGEPVPVPPGYTLVTVLGSPGREHALEVRVSGPDRVRPLPRHDDSTRVPRPWPLDGDERLAALALARRYLQNDPRPAPQSWRQVSDEMQQADPGGGWTHRRAEHTVRAIRERLSAAGVAGLLASEIEPPVGNRLNENLVAELIRTNTVTEPDLDELDREPG
>NZ_CP010989.1|WP_060574969.1|736441_738364_-|serine/threonine-protein-kinase
MTAPLVEGTVVAGRYEVRERLGAGGMGVVHRARDTALDRDVALKQVQTGAAAEDGAAAMRRLRREAQVAAQLHHGRIVTVFDVLELPAGPLLVMEYVPSAGLDALLTGTGPLAPGAAARIGAQVAEALAALHTAGIVHRDVKPGNVLVSDDGPVKLTDFGISLIPGRHSLTVGTLGTPAYFAPETARGDEPAAPADVYGLGATLRVAVDGEPPFGWADDSPLALIRRIADADPVPPPALDGPLGALLATMTAADPAARPTAAEAARRLWALADRDEPEPAAPADPGPTARRTTTPEVRPDDPTDPPGHATADGPVAARRRRLLFGGAAVVAVVAVVAAVALIPQERGADAPAPAPVALPASVPPLAAGDQRTADPCLADPAALAPFAPAVREPDYGNLAACSIVFVVGGDDAGGVDIRYRRATGSPPEGEQQRLGDAVLVRRPAEGTSCMRFLWLDDGTQVSISADHDAGRTRGLDPCAAAEAAAASAATRLAADGIPRRPVPPPGGSVLWTTDACGTLRPEDLTMLPAPARTDSYRDFAGWSCSWDAGDAGADLQLTVSFDRYDTPSATGQPLAGTAAFVRDDGPDACNGEVPVREFTGTNGRPMAELVRVKAEEGGRSTSQLCELAGRLADTAAARVR
>NZ_CP010989.1|WP_060574968.1|734404_736423_+|protein-meaA
MPYPTDRERDRPWVIRTYAGHSSAEKTNELYRRNLAKGQTGLSVAFDLPTQTGYDPDDELAKGEVGKVGVPVSHIGDMRALFDGIPVAEANTSMTINAPAMWLLSLYVAVAEEQAEQQGLDYSEVRAKLAGTTQNDIVKEYLSRGTYVFPPGPSLRLITDMVAWSVTEIPKWNPINICSYHLQEAGATPTQELAYALSTAIAVLDSVRDSGQVPPEKFGDVVGRISFFVNAGLRFVEEMCKMRALARLWDEITLERYGVENPKQRRLRYGVQVNSLGLTEAQPENNVQRIVLEMLAVTLSKDARARAVQLPAWNEALGLPRPWDQQWALRMQQVLAYETDLLEYEDIFDGSRVVEAKVSELVEGARAEIDRVQEMGGAVAAVESGYMKGELVSSLAAYRREMESGDRVVVGVNKFDTTEPSPLQAEGAGAIFTVDPETERSAIEAIGRWRSERDAAAVDESLRALRDAAKTEQNLMQVSIDCAKAGVTTGEWAGALREVFGEFRAPTGVSSASASGEGAGEIAEVRERVRATGDELGQRLRMLVGKPGLDGHSNGAEQVAVRARDVGFEVVYQGIRLTPSQIVAAAVQEGVHAVGLSVLSGSHLEVVPAVVQGLRDAGAGDIPVVVGGIIPPEDEKRLREGGIAAVFTPKNFRLTGMMDEIVTLVRDAQGLS
>NZ_CP010989.1|WP_010224404.1|733853_734192_-|hypothetical-protein
MEMDVVPRLGTIVGLVVVLVAIGLLLRWTFGHQKNVTLPTDDPDDPVATGLLTEVSRVPGKDAARILRDRLRAQGIRATITPGSDDRGGFALLVFPKDVPDARVVLSRGALD
>NZ_CP010989.1|WP_082398801.1|732994_733846_+|DUF1206-domain-containing-protein
MVSTPDAADVSRAGRRAASGARDVAHSTPVRIAARVGIAANGVLHLLIGWLAVQVALGSGAQADQNGALGAIAAEPLGRAFLWVLVVGFAAVVLWRAVSAVWGFGYVGDRSRRLVKRVVSAGQAVVYAVLAVAAAPTALSGRASSGGGGQATAGLLGLPGGQIVTALVGLGVLVGGGVMVWNGWQQRFLEDQDLAGADRRVRRLDARTGQIGFIAKGVAIGVLGILVGVAALTFDPARANGLDSALKALREQPYGVFLLVAVGLGIACYGVFCFFDARYHRVT
>NZ_CP010989.1|WP_082398804.1|745824_746862_-|AAA-family-ATPase
MPSTERAGARPGTGPAGAGAVSTRIAFGAAAPRPADPDPVSGSLSDDGGPELAPGDTVDLGEVRRAAGVDDVLDALDRELVGLAPVKQRLRELAALLVVDRVRARFGTATDRPTLHMCFTGNPGTGKTTVAQRMAGLLHGLGYLRRGHLVTATRDDLVGQYVGHTAPKTKEIVQKALGGVLFVDEAYYLHRPGNERDYGGEAIEILLQAMEDHRDDVAVILAGYADRMDTFFTANPGMQSRVAHHVDFPDFSVGELAEIGQRMVSDLDLELSGEARTTLHEYLTLRVEQPWFAGARSVRNALDRARMRQALRLSAGTGRIGLPELRTLTAADLRASRVFDGGLSR
>NZ_CP010989.1|WP_010228019.1|746848_747307_-|ribulose-bisphosphate-carboxylase-small-subunit
MRITQGTFSFLPDLTDDEITAQIGWALDHGWPCAVEFTDDPHPRNTYWEMWGMPMFDLADPAGVLAEIDACRREHPENYVRVNAYDASLGRQTVALSFLVQRPSEEPGFRLDRAEGGDRRIGYTVHPYATERPSGARYPVTGGHDGNGRAEH
>NZ_CP010989.1|WP_010228021.1|747321_748752_-|form-I-ribulose-bisphosphate-carboxylase-large-subunit
MSDRWSAGVIPYAEMGYWQPDYEPKDTDLLCAFRVTPQDGVPPEEAGAAVAGESSTATWTVVWTDRLTTYEHYQAKCYAVEPVPNTPGQWIAYIAYDLDLFEEGSIANLTSSIIGNVFGFKPLKALRLEDMRIPAHYVKTFPGPPHGIVTEREYLDKFGRPLLGATTKPKLGLSARNYGRVVYEALRGGLDFTKDDENINSQPFMRWRDRYLACMEAVNRAQAATGEVKGHYLNVTAATMEDMYERAEFARELGSVIVMVDLTVGYTAIQSLSTWARRNGVILHLHRAGHGTYTRQKNHGVSFRVIAKWMRLAGVDHIHAGTVVGKLEGDPNAVAGFYDVLRKGRYAADPVKGLYFDQDWVSMPATMPVASGGIHAGQMHQLLHHLGEDTVLQFGGGTIGHPMGIAAGAEANRVAVEAMIKARNEGADYLAQGPEILRAAARRNRPLETALATWGDVTFDYASTDTPDVVSTPTPA
>NZ_CP010989.1|WP_082398805.1|748776_750009_-|GAF-domain-containing-sensor-histidine-kinase
MTAAGRGLGLGDPERENAVLLGIIEATASGPGVEPLAAAVARMITEATATDVCFVHVLDDTDTALTLAGATPPFDARVGTVHLPLGHGVSGWVAAHRTPAVITDDKTSDPRYLPIPELRGQDYTSMVSVPMLSEPYGLAGVLNVHTVDRREFGDRDVRLLLAIGRLLAAALHQARMHRRLRAREQAHERFAEQTVAAQETERRRLARDIHDGISQRLVTLSFHLDAAGTLLGHGDTGGARTELACAAGLVGTTLDEARAAIGALRPPVLDDLGLAGALAALAREVPELDVRLDLDERRLPDHVEVALYRIAQEALQNVQKHAGAHRVVVRLADDDGGVRLDITDDGGGFATHGGPPGGYGMASMRERAELIGGTLRVRARPGSGTTVVVTAPGDTEPIDEESARNTRLSD
>NZ_CP010989.1|WP_010228026.1|750005_750668_-|response-regulator-transcription-factor
MTQATPLRLVVVDDHEMVVQGLKAMLAPFRGRVRVVGTAHDVTAAMDAALSLAPDIVLCDVRMAGDSGLDLCRRLHDRLPGQKVVLLSVYDDEQYLFQALRAGAAGYLLKRIGGEELVRQLELAATGVTVVDATMAGRAAASAARLERNEFWPGARLGLTHRESEVLALLVAGHSNRSVAAELVIGEETVKSHVRSVLRKLDVPDRTAAVAAALREGVFR
>NZ_CP010989.1|WP_010228028.1|750776_751721_+|phosphoribulokinase
MPDKSLRIRRAGPEEARRRPIMLAIAGDSAAGKTTLTRGLVEALGPDRCVSLCTDDYHRYDRAERRDLPFTALHPDCNFVEIMEQHLQLLATGEPVLKPVYDHSTGELARPEPVEPAEVVIVEGLLPLHSKLSRACFDVTVYLDPPEEIRRDWKVQRDCAKRGYTPDQVLAELDRREPESAEHIRPQRRHADLVVRFAPIESRDDPEGTPLSATVMLRPTIPHPDLSGVMQPGLTRAMHLKLERDPDGRPVESLHVHGYVPHEESVAVEKSIWAEMGDAGRDTPDCLGRVGDGRSEPLAIAQLLILFHLMELGR
>NZ_CP010989.1|WP_060574973.1|751717_752479_+|HAD-IA-family-hydrolase
MSAPEAVLFDVDGTLAETERDGHRPAFNRAFAEHDLGLHWTPAHYTRLLRVPGGRQRIAADLRTRGVPGVEADRVAAAVHRTKTALFAEHARSGSIPARPGVRTLVADLRRHGTRIGVVTTGRREWAEPLVRHLIGDVAGALDVAVYGDDVTALKPDPQAYRLALRRLGLPASCAVAVEDSAPGLQAALGAGLMTVVVRSEPTAGHDARGAALVRDSFDGDPPLDAVLLRELLTAAEDQALAARRSSCRRSSA
>NZ_CP010989.1|WP_060576472.1|752430_752937_-|NUDIX-hydrolase
MTVREDGIRLSDGTEGIYGVVDKPTYALVVPRDDDGRLHLVEQFRYPVGERRWEFPAGTAPDRADQDPAELAVRELAEETGLAASSMALLGTLDCAPGMSSQRGHVYLATGLTEGPPRREHQEQDMRAAWFTAVEFERMILDGRLTDAQTLAAYALLRLHDERRAASA
>NZ_CP010989.1|WP_060574974.1|753044_753704_+|endonuclease-NucS
MRLVIARCQVDYAGRLTAHLPMAPRLLLVKADGSVSVHADDRAYKPLNWMSPPCWLTEEPGVWTVKNKADESLVITIDEVLHDSSHELGVDPGLVKDGVEAHLQELLAAHPETFGDGWTLVRREYMTAVGPVDLLCRDGDGGHVAVEIKRRGEIDGVEQLTRYLELMNRDPLLAPVQGVFAAQQIKPQARTLATDRGIRCLTVDYDELRGMTSKDMRLF
>NZ_CP010989.1|WP_060574975.1|753717_754140_-|hypothetical-protein
MPIASILLAALVVTGCAAGRTEGAAPAATGVPTTASAPPTTTAAPDPTCTGSMERRTDGRTSTNFGGGAGGTLQTSDAGTFVSCGDGPRIRIRIDPGAALVASFEGRDVRIGERRSDAVGPYRVAVTSLTGNAVRFTVTP

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Crispr_ID: NZ_CP010989_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010989_3

4286383-4286541

Orphan

Consensus_repeat	Method
CCCCGGCTCCGCTGCCCACCCCGGAGGACCCCTGTCGCGGAATCGCTTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010989_3

>merge|NZ_CP010989|3|4286383-4286541|CRISPRCasFinder
CCCCGGCTCCGCTGCCCACCCCGGAGGACCCCTGTCGCGGAATCGCTTCCCCAAGCAGCGAATCCACAGAACCCCCTCCACCCAGAGCAGCTCCCGAGCCCGGCCCGCGCCCCCGCTCCGCTGCCCACCCCGGAGGACCCCTGTCGCGGAATCGCTTCC

>NZ_CP010989|3|3|4286383-4286541|CRISPRCasFinder
CCCCGGCTCCGCTGCCCACCCCGGAGGACCCCTGTCGCGGAATCGCTTCC	CCAAGCAGCGAATCCACAGAACCCCCTCCACCCAGAGCAGCTCCCGAGCCCGGCCCGCG
CCCCCGCTCCGCTGCCCACCCCGGAGGACCCCTGTCGCGGAATCGCTTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010989.1\|WP_060573569.1\|4297829_4299206_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP010989.1\|WP_060633801.1\|4275065_4276256_+\|aminotransferase	unknown	unknown	gnl\|CDD\|181026
NZ_CP010989.1\|WP_060573560.1\|4287652_4288870_-\|mycofactocin-biosynthesis-FMN-dependent-deaminase-MftD	unknown	unknown	gnl\|CDD\|274885
NZ_CP010989.1\|WP_060573567.1\|4294709_4295720_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223687
NZ_CP010989.1\|WP_029239769.1\|4296831_4297833_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NZ_CP010989.1\|WP_060573556.1\|4284029_4284872_+\|DUF5134-domain-containing-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_082399531.1\|4276392_4277724_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP010989.1\|WP_060573547.1\|4277792_4278926_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|225109
NZ_CP010989.1\|WP_060722231.1\|4273777_4274953_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340913
NZ_CP010989.1\|WP_010236091.1\|4301108_4302548_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP010989.1\|WP_060573548.1\|4278949_4280599_-\|GMC-family-oxidoreductase	unknown	unknown	gnl\|CDD\|225186
NZ_CP010989.1\|WP_082399537.1\|4284928_4286299_+\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|377164
NZ_CP010989.1\|WP_060722232.1\|4281971_4283237_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|226363
NZ_CP010989.1\|WP_060573554.1\|4283303_4283900_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|237130
NZ_CP010989.1\|WP_139324044.1\|4295656_4296778_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|376439
NZ_CP010989.1\|WP_075300051.1\|4292852_4294592_+\|LCP-family-protein	unknown	unknown	gnl\|CDD\|224235
NZ_CP010989.1\|WP_060573572.1\|4299249_4300854_-\|asparagine-synthase-(glutamine-hydrolyzing)	unknown	unknown	gnl\|CDD\|236513
NZ_CP010989.1\|WP_010235877.1\|4286710_4287604_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235737
NZ_CP010989.1\|WP_060573550.1\|4280803_4281928_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|99740
NZ_CP010989.1\|WP_060573563.1\|4290468_4291407_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP010989.1\|WP_060573569.1\|4297829_4299206_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.2559e-122
NZ_CP010989.1\|WP_060633801.1\|4275065_4276256_+\|aminotransferase	gnl\|CDD\|181026	PRK07550, PRK07550, aminotransferase.	2.79822e-156
NZ_CP010989.1\|WP_010236091.1\|4301108_4302548_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	1.75069e-150
NZ_CP010989.1\|WP_060573567.1\|4294709_4295720_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|223687	COG0614, FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism].	1.23926e-52
NZ_CP010989.1\|WP_029239769.1\|4296831_4297833_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	8.88896e-68
NZ_CP010989.1\|WP_139324044.1\|4295656_4296778_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	3.80425e-74
NZ_CP010989.1\|WP_082399531.1\|4276392_4277724_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	9.25376e-58
NZ_CP010989.1\|WP_060573547.1\|4277792_4278926_+\|diguanylate-cyclase	gnl\|CDD\|225109	COG2199, COG2199, c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms].	1.64429e-10
NZ_CP010989.1\|WP_060722231.1\|4273777_4274953_-\|MFS-transporter	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.86874e-57
NZ_CP010989.1\|WP_060573548.1\|4278949_4280599_-\|GMC-family-oxidoreductase	gnl\|CDD\|225186	COG2303, BetA, Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism].	6.80691e-32
NZ_CP010989.1\|WP_060722232.1\|4281971_4283237_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|226363	COG3844, COG3844, Kynureninase [Amino acid transport and metabolism].	6.77919e-110
NZ_CP010989.1\|WP_082399537.1\|4284928_4286299_+\|PepSY-domain-containing-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	7.77081e-67
NZ_CP010989.1\|WP_060573560.1\|4287652_4288870_-\|mycofactocin-biosynthesis-FMN-dependent-deaminase-MftD	gnl\|CDD\|274885	TIGR03966, actino_HemFlav, heme/flavin dehydrogenase, mycofactocin system. Members of this protein family possess an N-terminal heme-binding domain and C-terminal flavodehydrogenase domain, and share homology to yeast flavocytochrome b2, to E. coli L-lactate dehydrogenase [cytochrome], to (S)-mandelate dehydrogenase, etc. This enzyme appears only in the context of the mycofactocin system. Interestingly, it is absent from the four species detected so far with mycofactocin but without an F420 biosynthesis system.	0
NZ_CP010989.1\|WP_060573554.1\|4283303_4283900_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|237130	PRK12535, PRK12535, RNA polymerase sigma factor; Provisional.	1.2127e-46
NZ_CP010989.1\|WP_075300051.1\|4292852_4294592_+\|LCP-family-protein	gnl\|CDD\|224235	COG1316, LytR, Transcriptional regulator [Transcription].	8.00356e-36
NZ_CP010989.1\|WP_060573572.1\|4299249_4300854_-\|asparagine-synthase-(glutamine-hydrolyzing)	gnl\|CDD\|236513	PRK09431, asnB, asparagine synthetase B; Provisional.	1.70749e-170
NZ_CP010989.1\|WP_010235877.1\|4286710_4287604_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235737	PRK06197, PRK06197, short chain dehydrogenase; Provisional.	5.95758e-122
NZ_CP010989.1\|WP_060573550.1\|4280803_4281928_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	7.54166e-105

>NZ_CP010989.1|WP_082399537.1|4284928_4286299_+|PepSY-domain-containing-protein
MFRGLKPLITRVHFYAGLFVGPFLLVAAVTGLLYTVSPQIERWVHADALTVPVSGPERPIGDQVSAALATQPGLTVTEVRPSPEPGTTTRVSFDADLPESYARTVFVDPYTAQPVSTLDTYAEWLPVRGVIDNLHRSLLLGPPGQVYTELAASWLAVLTLSGLVVQLSRRVRARRDRFVPRAAGSQRARLRSWHGAVGLWASVGFLFLAATGLTWSLFAGSNVTQLRQAMDWTTPSVSSTLPDAAPGGSGGSGDTGSPGGSAGTDPAATAQRVLDAARADGLGGPVEIAPGDAGEAWRVQQAVRSWPEQQDSVAVDPATGVVTDRLAFADWPVAAKLARWGVDAHMGLLFGTVNMIALAALALALIVLVVWGYRMWWLRRPAVRGAGAGPPGSRERPSPASVALLAGLAVVVGIVLPVLGVSLILFLLLDAALTARRGAGAGDQSPDPVGRPGPVG
>NZ_CP010989.1|WP_060573556.1|4284029_4284872_+|DUF5134-domain-containing-protein
MITSVPLAWALTALFTATGGYALARWSEAVSARRSAAHRTAELAHVVMSAAMVLMTWTWSGTAGLAVQIALFAVFALFFVVTAARGIHCGPTGPVAGAAHALMAAAMVWMLAAMPVIMPVAAASSGGGGHAGHAGHGGGSGDAGHAMHAGQAGWAVAATVVLCAALLAVAGFWAVRALSHGTRSGDPFTPDDDVTGGAAVGCPDGCAPGTDAATAAAPAGVDSDVPARADSAAAGTATVLAERPAATPAASRLGARTDAACHAVMSVGMVVMLAAMVAGW
>NZ_CP010989.1|WP_060573554.1|4283303_4283900_+|sigma-70-family-RNA-polymerase-sigma-factor
MSRRPDDATVTAWALAAGAGDQAALSSFVRATQADVHRFLVHLNGRADAEDLAQETYLRALRTLPTFEARSSARTWLLSVARRVAVDAVRTAVRRPRTRDLGEDTAEVIERALPRTGAHEAVLLRALIDDLAADRREAFVLTQVLDLGYAEAAEVCRCPVGTIRSRVARAREDLVRALDADGGTRTERAGRAARSAPS
>NZ_CP010989.1|WP_060722232.1|4281971_4283237_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MTGPLDPAPHDDADPLARFRDRFAPAPGVVAYLDGNSLGRPPAATAERLARFVREDWGTRLIRGWDEGWWTRPEDLGDRLGALALGAAPGQTVVADSTTVLLYKLARAAVALRPGRDEIVTDAADFPTDRDLLAGIAAERGLRLRRIDTDPAGGITPEEVSAAVSERTALVSLSHVAYRSGRIADAAAITRIAHDAGALVLWDLSHSAGSVPVELDRWGADLAAGCGYKYLNGGPGAPAFGYARAGLLPGIENPVRGWVGRAEPFAMDADFAPDPGIRRLLSGTPPVLATVPLQVSLEMLAEAGTGAVREKSLRLTSYVLDLADAWLEPLGVTVASPRDPRHRGGHVMLTRPGFADLLAPLHAAGVIPDFREPDGLRIGPAPLSTSFAEVHAGMAVLRDMIAREPGSAPGSVRTAPVDHRT
>NZ_CP010989.1|WP_060573550.1|4280803_4281928_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MAATVRVLGRGELGRFTGGDRSEVARFERELAAHVGTGHALAVNSGTSALVAALVGAGIGPGDEVLVPAYTWVSTAAAALAVGAVPVLVEIDGSLTMDPADLKDRITTRSRAVVPVHMGNQVADMDAIMEVAAAHDLVVIEDACQAIGVSYRGRKVGSIGHAGCFSFNQHKNIRAGEGGALVTNDAALFERASMYHDVGSYERPGWAGNDADLIVGVNLRMPELSAAVLRPQLAGLDRQIARRRRHRTIVLDALASRKDLEPVPHHDPLAAAGLAVRFDGAADPVRSATAFAGNRGVHRLIDTGRHVYTNWRSLQARNPVHPALDQYAAVDADIDHGPTACPRTLEILARTCAVDLAPELPTPAFRLLAGRIAG
>NZ_CP010989.1|WP_060573548.1|4278949_4280599_-|GMC-family-oxidoreductase
MLIDTRRALPGSWFEAEVCVIGSGPAGAAVAAELADRGLRVVVLEGGGPGLGRTARDTYRGVTGRGAHDPVDAVRQKRLGGTSIVWGGRCAPLDDVDFAERDWLPGSGWPISHDELQGWYAVAQRHLDAGACEYSAASSGFPLTPSGVSSDVLRWDDLWRWSPPTSFAPRVEAMARAGRIRLFLHATVTRLERDPVSGAATEAVVVPRPGLEVRVRARHFVVAAGGLESTRILLASDGYGGTGMGTGIGDEYGQVGRHYMTHPVGEVGRLRLTKAGRSLGLGYLPTDDGVYARRMLSLTPRAQADHRLGNLKAALWFADPKDPAHGDALLSTFALTYWGMGRIRTGFKAAGTHAQYARTTGIGRHVRNVAADPLRVARFARGWVRPRITGERRVPSFMPLDTGHCRLRFDAEQTPDPANRVTLDRERDALGQHRLRVDYRVSAADRDAIATSLTLIGKELERTGLAHVDLSDVEQVHSMDMTDGTHQMGLLRMSDSPRTGVVDPDCRVHGTPNVHIASSAVFPSAGAVGPTLALVALACRSAEGIALES
>NZ_CP010989.1|WP_060573547.1|4277792_4278926_+|diguanylate-cyclase
MRGAGPEPVTVADDAGRPSRTVTTPLLAAVSRAVEDFALAPSRDRPTAVVGLVQRAGYLEPHLGTWARIAERCGDGAVVAVAGEPPEGLPPGLGYVPLADGEPAAREWSVTVLTPRSGATVVAHDLEAVDGSARSLERGRLFTARWSFRHSDAHAELLRLRRELGPRLGPRRTGALDEVLSRVVPIPGTATDHRYDAAADRLARSLSDERRRADLAENRLDAHEPGAERDPRSGLPTRAFLDRWMHGSAPGTLPLGLVLLRVHGLGTVNRMHGFRAESSVLQGVARLLGGHTGATGRPVRVGREEFLLVLPGLDVRTLAGTARRLCESVAGLSSAFPFVPTPCHAVITRTRDRPLPLDALWAALDGAAGTGVTLLRG
>NZ_CP010989.1|WP_082399531.1|4276392_4277724_+|MFS-transporter
MAMLDNTVVTIALPRIGEELGAGFAGLQWTVNGYTLTLAWLILLGGSLGDRFGRRRVFVTGAVWFAVASLLCALAPTVELLAVARALQGVGGALLTPGSLALISASFHGADRAAAIGAWSGLGGVAGALGPFVGGTLVEWSWRAVFLINLPLAAVVVAVALRHVPESRDPEAPHRPDLPGSVLAVAGLALLTWAGTAAGTGGTPGPAVWAAGAAGVVALVAFALAERRSPSPLVPPDLFTGSAGRRFTGANLVTVAVYAALSLLFVLIAVQLQVVAGFSPLLAGTATLPVTVLMLLLSPRAGRLATRTGPAPLVTTGLLLAAAGAFLAGRLDAGASWLLDVLPATALVGLGLSAAVAPLTTAVLDAASDRHAGVASGVNNAIARAAGLLAVAVVPAVAGIRGDGPADAASFGPGFGVAMTIASALLVVGAVLAAALLRRSDAT
>NZ_CP010989.1|WP_060633801.1|4275065_4276256_+|aminotransferase
MRLDPTTAAGSDSPIGAALALAGERDPARDAEHPLLDLSQAAPAYPPAPEVVEQVVATAQDPATLGYAPVPGLPPLRRAIADELSRDYAGTVTPDDVTVTAGCNQAFAVVADALAGPGDEMIMPLPYYFNHQMWLTMRGVRPVYLEPDEQLVPRAADAEALITPRTRAIVLVTPGNPSGVTVPPSEIVAFAGLARRHGIALVVDETYRSFRDAADEPAHPLFADPDWRDTVVSLHSYSKDLAIPGYRAGSVVAGADLTRQVLKLLDCVAICAPRVGQEAALAGLTRAGTWRAERVAEVARRRAWLGAALADRPGGFEVVALGAFFAWVRHPFEGTPTLDVVRELVLGHDTLTIPGTAFLPDDRRMLRLSVGKVDEAAAATLATRLAAAGSRAGAAS
>NZ_CP010989.1|WP_060722231.1|4273777_4274953_-|MFS-transporter
MHDPVPRRRVLAVLRLTELTSWGVLYYALPVLAPAISDDTGWSHSAVTGAFSAGLVVSALAGIGVGRVLDRWGPRWPMTAGSLLAVPAVVAIACAGSWPWFLAAWLLAGLAQSATLYPPAFAALTRWWGTDRVRALTWVTLAGGLASTVFAPLTAALLEPFGWRGTYLVLAVVLGVVTVPAHLFGLRGPWPEAPEPPRGARPGAITRSPAFLLTVAAVCLGVFCSFAVAVNQVPLLIERGLDVQTAAWALGLGGLGQVAGRAFYARTVGRLGVRTRAVVVLAGLGATTALLGLLPGPAWLLVAVAVLTGAARGITTLLQATAVSDRWPSRYYGRLNGLLSAPATAAVAISPWAGAALAGPLGGYPALFVVLAGATTLGALLALGSRPPSSR
>NZ_CP010989.1|WP_010235877.1|4286710_4287604_+|SDR-family-NAD(P)-dependent-oxidoreductase
MFRNSPAPWTAADIPDQSGRTVVVTGANSGLGLETARALVDAGARVVLAVRDTAKGDAVAGELGGAATVRRLDLADLTSVREFAAGVEGPIDVLVNNAGLMAVPQSRTADGFETQLGVNFLGHFALTGLLADRITDRVVTLSSVMHRIGRIDLDDLNFRRRRYERWTAYGQSKLACLMFAYELEHRFVAAGSRLRSTAAHPGYSATNLQSRTESVQDAVMGVLNRIVAQPAAAGALPTLFAATVTDLPGGAYIGPDGIGEARGHPRPVGSTAASHDRRVQAALWERAEELTKVAFPV
>NZ_CP010989.1|WP_060573560.1|4287652_4288870_-|mycofactocin-biosynthesis-FMN-dependent-deaminase-MftD
MASTKDWFETVAEAQRRARRRLPKSVYYALVAGAEQGITLADNVAAFDEIGFRPHIAGLPPQREQRTSVLGQEIDFPVVISPTGVQAVDPEGEVAVARAAASSNIQNPLNPEQTVSTAMGLSSFASRSVEDVCAVNDKVFFQVYWAGSREDILARAMRAKRAGAKGLIVTLDWTFATRRDWGSPPIPEKMDLKAMMQFAPEVINKPRYLLDWARSGKLPDLKTPNMAPPDGGDAPTFFGAYGVWWTSPLPTWEDLAWLREQWDGPFVIKGIMHPDDARRAVDAGATAISVSNHGGNNLDGTPAAIRALPAVVDAVGDQVEVLMDGGIRRGADVVKALALGARACLIGRAYLWGMAAQGERGVTNVLSILYKGIDEALLGLGKSSIHELSRDDLIVPENFTRTSKL
>NZ_CP010989.1|WP_060573563.1|4290468_4291407_+|hypothetical-protein
MRPAAVLTAVLALCAVLAGCTSDPPAAAEPPPPAPAAPPADAAPPVPELPGGGTEVFPGRRMAALYGHPGTPSMGVLGEQDLPRSIARARDLAADFQPLVREPVVPAFEIIATVADSVPGADGDYSAEMSVDELRPWVTEAGKAGVYVVIDLQPGRADFLTQAKRYTELLAQPHVGLALDPEWRLEPGQRHGDQIGSVDAAEVNATSAWLAGLVRERGLPQKVFLMHQFRVPMIADRQAVVTSHPELATVLHADGYGTPQEKLDTWNVLHSAPRPEGLWWGWKNFLDEDTPTFTPRRTYDVRPESPVFVSYQ
>NZ_CP010989.1|WP_075300051.1|4292852_4294592_+|LCP-family-protein
MAGAAAGAAPGAVAPGRTGRPGAADEDRQEDDRPPGRRRTLDTARASLGAALGLTAASTVLPGSGHLALRRRRTGGLILGTLLAVVVGLAVLVLLTRRSVLLQNLLSTTTLTVIAGALVLGGIGWIAQVARTYALARPRTLPLGQKIIGTGTAALLCLTVAVPFGYGVELLNSQRGLLDSLFQGGGTSAAEALGKPRLNVLLLGSDAGDDRSGTRTDTMMVASIDTRSGRTTLFSLPRNIQRAEFPPGSPAAEEFPDGFHDSSQPLSGDYLLNGVFAYGEQNPEIAPPTPTAEPGLNLLQSTISYMTGLPIDYYLEVNMAGFSSMIDAVGGVTVNVGQEPIPVGGVTAFGRYVTPDRYIPPGMQTLNGEDALWFARSRRDGTDYQRMGRQRCLIQAVISETSATELIGRFQSIAAVTRDNVSTDMPQQVLPSLAVLADEGFRLESVAFDPSLPDPNSSTGYFVTADPDADYMREVVRGAIADPPPPPDPALAAPAPAPAPAAPSSEAPSSSESGAPSSSAAPEPASTAPQSVEDSCASTGAADVPSEEEQGAAESAEDSGSGTTTTGLGPVGGIRPDEY
>NZ_CP010989.1|WP_060573567.1|4294709_4295720_+|iron-siderophore-ABC-transporter-substrate-binding-protein
MLRRTPSVLAALLAALALLAGCGSGSDPAPGGEGATAPAADGAFPVTIPTAFGEVTVPEQPQRVVALGWSDAETALALGVEPVGAADWLAVGGDGLGPWVPQDYTTPPTVLGTLEVDLEAVAALDPDLILDTRAAGTRDRYDRLTQLGVPVVSIPAGGENYLTNWRDQLRMVGAAVGRPGEAAQLQSGLEQRFADARAQHPQLAGATVVSGARNTLGEYAAYTAGSGRMEFLEELGMTLAPQIAALPTEGFSTPISRERMNLLDADVTVMQPIGKDATEIENDPLWQAVPSVAAGRGVLLSDRDVSQAFSAASVQGWTFALDRTVPRLADAAAAAP
>NZ_CP010989.1|WP_139324044.1|4295656_4296778_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MDVRAGPHGAAPGGRGRGRTVTAGPAAPAVAEPDAPPAAARRARVRRAAVVLVVLLAGSVTASMLVGAGMLAPATVADALFGDGPVTPESLVVTDVRLPRTVLALLAGAALGVAGVLAQGMTRNPIAEPGLLGLNTGAALAVVLGIGVFGVSTLTGYVWFGFLGAALAAVVVGGVAGVGRSSRTVSPAALALAGAAVAAGLGSVITVFLLTNPTLFDDYRFWQVGSVAGRDLSIAAQAAPFVVAGLALALTCGQRLDALALGDDVARSFGRRPGADRLVCGLALVLLAGTATAAAGPIAFVGLAVPHVLRALTGPGHRTLLPLAVLAGPSLLLLADVLGRVVVPPAEVQAGVVTAVVGVPLFVALVRRRKFVR
>NZ_CP010989.1|WP_029239769.1|4296831_4297833_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MRARRRRRVLVSGAVVAAAVLAAFVVTLSAGAQLVPPADVVAALLGSGSPRTELVVLRLRLPRALTAVLVGAALGLAGALFQRLLRNQLASPDIIGISAGASAAAVAGTVLLGLSAAGVSVAAVLGAVATTVLILALTHRDGLHGVRFVLVGLGIGTGLLAVVSFLMIRASLTSAQENLVWLTGSINQADWSRTVPLVAACAVLVPLALVLARALPRLELGDDTATALGLPVGRARLALIAVGVLLVATAVAAAGPVSFVALVCGPLATRAAGPGNGSLPHAAGIGALVVLVSDLVARHLVNDVALPVGVVTGAVGAPYLLWLLARARTRGTT
>NZ_CP010989.1|WP_060573569.1|4297829_4299206_+|ATP-binding-cassette-domain-containing-protein
MSLTADDLVLRYDDRVVADGLTVRLPPGRITAIVGPNACGKSTLLRGLGRIITPAAGHVALDGTDVREIGGRELARRLGLLPQSPVAPDGITVADLVERGRSPHQGWFGGHGDADDAAVAAAMRATGVLELADRPVDELSGGQRQRVWIAMVLAQDTGVLLLDEPTTFLDMTHAVEVLDLLVDRNRAEGTTVAVVLHDLNLACRYADHLIAMRDGAVVAEGPPAATMTVDLVRRVFAMESQVVPDPVTGTPMVVPAGRHLPVPAPGAGPRTADGPGPRTESDLREVVGEPHPLVLDKSADRIDDVAASFVAAATLAFVGTVGASGSVTVTPRGNPPGDGPRVLDGGRRIALPERPGNRRLDSLRNLLDRSGIGLTFCVPRVEHVLRVNGHGRVVRDAEVLGLWEDPPELAIVVDVEETFVHCGRALRTSGTWRPEDWADPSGVPSSKELAAAARATRD
>NZ_CP010989.1|WP_060573572.1|4299249_4300854_-|asparagine-synthase-(glutamine-hydrolyzing)
MCGIVAAFGGTAVGAPKDFEKYERMLARVAHRGPDDTGVQVVGNTWLGHQRLSIMDVSGGHQPMSDADETAWIVGNGEIYNHERISKAFPDGTVRTKSDTEAALHAVMWDGQVAVASLNGMFAVAMGREDGSGLVARDPFGVKPLYWVPPADVGGTDVPYTAPDPEATVLFASELRAFDEEDRPYVESFPPGCLWSPSSGLVRFAEAVPVEVRPSRRAIRPGWDEADLSRVREAVVSAVRRRMMSDVGVGVFLSGGLDSALVAAIAAQEARARGEQLPTFAVGTADSGDLIAARKVAAHIGSDHHEIIVTAEDIGEALDHAVEVIEHYDPALVRSSVPNLILAREAAKKVKVVLTGEGADELFAGYSYTHTDDYADPDTLQAELVRSLEQLHHLNLQRCDRTTMYFGLEAREPFLDSGLVRTALALPPEWKQRTDGRPEKAILREAFEGWLPEDLLWRGKEQFGDGSGAGTVLAELAGRKAAEARESGETRSVPEQPEYSWPLRSEEEYLYYEIWQSHFAGIRPDRVLGAFATA
>NZ_CP010989.1|WP_010236091.1|4301108_4302548_+|NAD(P)/FAD-dependent-oxidoreductase
MSTAGHDEGTGRQKVVIVGGGFGGVQAAKALKGADVDVTIVDRTNHHLFQPLLYQVATGILSPGLIAPALRRVLKKQDNVRTLLAEVGEIDLETKIVHAASPDGQHIDLPYDTLVVAAGATHAYFGHPEWAEHAPGMKSIEDARLLRSRILGAYELAEVAPTEEEQRAWTTFVVVGAGPTGVELAGQLSELARHVLPREYRAIDTRDARIILLDAAPAVLPPFAKKLQNYTRKTLEKKGVEVRLNTMATDIDADSITVKGPQGTDRIVARTKVWAAGVQASPLAELLAKASGGEVDRAGRLSVDPDCSLPGRRDVFAIGDMVSTIDRLPGVAQVAMQQGTYVGKLIKARSKGDDTTPAPFTYFDKGSMATIGAREAVADVRGVKFTGWLGYLMWCYVHVMFLIGWGNRLGTLYNWVRSLRYARYRGHRLISVTASYDKAEPHHGDAGLPAEKAEHRSEVDPRTAPGTPAPPEEKPAASA

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Crispr_ID: NZ_CP010989_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010989_4

4313189-4313293

Orphan

Consensus_repeat	Method
GCTCACCCGATCGCACGAGCGGGGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010989_4

>merge|NZ_CP010989|4|4313189-4313293|CRISPRCasFinder
GCTCACCCGATCGCACGAGCGGGGCCGCATTCCGTGAGCGGCGCGGCGCGGCACCCAGACGCTCAGCGGTTCCGGCCACGCTCACCCGATCGCATGAGCGGGGCC

>NZ_CP010989|4|4|4313189-4313293|CRISPRCasFinder
GCTCACCCGATCGCACGAGCGGGGCC	GCATTCCGTGAGCGGCGCGGCGCGGCACCCAGACGCTCAGCGGTTCCGGCCAC
GCTCACCCGATCGCATGAGCGGGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010989.1\|WP_060573589.1\|4318044_4319544_+\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP010989.1\|WP_060573577.1\|4303768_4304677_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|131480
NZ_CP010989.1\|WP_060573581.1\|4305350_4306991_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225827
NZ_CP010989.1\|WP_060573593.1\|4322650_4323061_-\|TIGR03618-family-F420-dependent-PPOX-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NZ_CP010989.1\|WP_060573592.1\|4321814_4322615_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293841
NZ_CP010989.1\|WP_060573586.1\|4309641_4309983_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|272994
NZ_CP010989.1\|WP_145982682.1\|4302640_4303084_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|377824
NZ_CP010989.1\|WP_060573579.1\|4304658_4305354_-\|response-regulator	unknown	unknown	gnl\|CDD\|226931
NZ_CP010989.1\|WP_010236095.1\|4303320_4303632_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_060722234.1\|4308234_4309632_+\|GntP-family-permease	unknown	unknown	gnl\|CDD\|308194
NZ_CP010989.1\|WP_010229352.1\|4311851_4313099_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173852
NZ_CP010989.1\|WP_010242245.1\|4316008_4317175_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_CP010989.1\|WP_060573591.1\|4319742_4321125_+\|sugar-porter-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340917
NZ_CP010989.1\|WP_050802561.1\|4314377_4315688_-\|TMEM165/GDT1-family-protein	unknown	unknown	gnl\|CDD\|225030
NZ_CP010989.1\|WP_060722236.1\|4323071_4324286_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|376311
NZ_CP010989.1\|WP_060573583.1\|4307058_4308066_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP010989.1\|WP_060573595.1\|4324365_4325529_+\|citrate-synthase/methylcitrate-synthase	unknown	unknown	gnl\|CDD\|99862
NZ_CP010989.1\|WP_060722235.1\|4313464_4314286_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187578
NZ_CP010989.1\|WP_010229351.1\|4310247_4311417_+\|dimethyl-sulfone-monooxygenase-SfnG	unknown	unknown	gnl\|CDD\|274923
NZ_CP010989.1\|WP_060576278.1\|4321134_4321761_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223659

Protein	Function_ID	Function_description	E-value
NZ_CP010989.1\|WP_060573589.1\|4318044_4319544_+\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	8.10741e-89
NZ_CP010989.1\|WP_060573577.1\|4303768_4304677_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	8.29582e-23
NZ_CP010989.1\|WP_060573581.1\|4305350_4306991_-\|sensor-histidine-kinase	gnl\|CDD\|225827	COG3290, CitA, Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms].	1.1406e-108
NZ_CP010989.1\|WP_060573593.1\|4322650_4323061_-\|TIGR03618-family-F420-dependent-PPOX-class-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	5.46349e-18
NZ_CP010989.1\|WP_060573592.1\|4321814_4322615_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293841	cd16283, RomA-like_MBL-fold, Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain. Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.24379e-36
NZ_CP010989.1\|WP_060573586.1\|4309641_4309983_+\|HD-domain-containing-protein	gnl\|CDD\|272994	TIGR00277, Ribonuclease_Y, HDIG domain. This domain is found in a few known nucleotidyltransferes and in a large number of uncharacterized proteins. It contains four widely separated His residues, the second of which is part of an invariant dipeptide His-Asp in a region matched approximately by the motif HDIG. This model may annotate homologous domains in which one or more of the His residues is conserved but misaligned, and some probable false-positive hits.	0.000547664
NZ_CP010989.1\|WP_145982682.1\|4302640_4303084_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|377824	pfam07366, SnoaL, SnoaL-like polyketide cyclase. This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalyzing intramolecular aldol condensation.	5.62643e-05
NZ_CP010989.1\|WP_060573579.1\|4304658_4305354_-\|response-regulator	gnl\|CDD\|226931	COG4565, CitB, Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms].	2.71416e-64
NZ_CP010989.1\|WP_060576278.1\|4321134_4321761_-\|hypothetical-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	1.63979e-16
NZ_CP010989.1\|WP_060722234.1\|4308234_4309632_+\|GntP-family-permease	gnl\|CDD\|308194	pfam02447, GntP_permease, GntP family permease. This is a family of integral membrane permeases that are involved in gluconate uptake. E. coli contains several members of this family including GntU, a low affinity transporter, and GntT, a high affinity transporter.	6.22454e-101
NZ_CP010989.1\|WP_010229352.1\|4311851_4313099_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173852	cd01163, DszC, Dibenzothiophene (DBT) desulfurization enzyme C. DszC is a flavin reductase dependent enzyme, which catalyzes the first two steps of DBT desulfurization in mesophilic bacteria. DszC converts DBT to DBT-sulfoxide, which is then converted to DBT-sulfone. Bacteria with this enzyme are candidates for the removal of organic sulfur compounds from fossil fuels, which pollute the environment. An equivalent enzyme tdsC, is found in thermophilic bacteria. This alignment also contains a closely related uncharacterized subgroup.	1.7131e-132
NZ_CP010989.1\|WP_010242245.1\|4316008_4317175_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	5.10241e-170
NZ_CP010989.1\|WP_060573591.1\|4319742_4321125_+\|sugar-porter-family-MFS-transporter	gnl\|CDD\|340917	cd17359, MFS_XylE_like, D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily. This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.29967e-115
NZ_CP010989.1\|WP_050802561.1\|4314377_4315688_-\|TMEM165/GDT1-family-protein	gnl\|CDD\|225030	COG2119, COG2119, Predicted membrane protein [Function unknown].	1.0752e-41
NZ_CP010989.1\|WP_060722236.1\|4323071_4324286_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|376311	pfam00285, Citrate_synt, Citrate synthase, C-terminal domain. This is the long, C-terminal part of the enzyme.	5.74665e-57
NZ_CP010989.1\|WP_060573583.1\|4307058_4308066_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.59843e-60
NZ_CP010989.1\|WP_060573595.1\|4324365_4325529_+\|citrate-synthase/methylcitrate-synthase	gnl\|CDD\|99862	cd06109, BsCS-I_like, Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and OAA to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. The overall CS reaction is thought to proceed through three partial reactions and involves both closed and open conformational forms of the enzyme: a) the carbanion or equivalent is generated from AcCoA by base abstraction of a proton, b) the nucleophilic attack of this carbanion on OAA to generate citryl-CoA, and c) the hydrolysis of citryl-CoA to produce citrate and CoA. This group contains proteins similar to BsCS-I, one of two CS isozymes in the gram-positive B. subtilis. The majority of CS activity in B. subtilis is provided by the other isozyme, BsCS-II (not included in this group). BsCS-I has a lower catalytic activity than BsCS-II, and has a Glu in place of a key catalytic Asp residue. This change is conserved in other members of this group. For E. coli CS (not included in this group), site directed mutagenesis of the key Asp residue to a Glu converts the enzyme into citryl-CoA lyase which cleaves citryl-CoA to AcCoA and OAA. A null mutation in the gene encoding BsCS-I (citA) had little effect on B. subtilis CS activity or on sporulation. However, disruption of the citA gene in a strain null for the gene encoding BsCS-II resulted in a sporulation deficiency, a characteristic of strains defective in the Krebs cycle. This group contains proteins which functions exclusively as either a CS or a 2MCS, as well as those with relaxed specificity which have dual functions as both a CS and a 2MCS. Many of the gram-negative species represented in this group have a second CS isozyme which is in another group.	5.12314e-130
NZ_CP010989.1\|WP_060722235.1\|4313464_4314286_-\|NAD(P)H-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.28621e-39
NZ_CP010989.1\|WP_010229351.1\|4310247_4311417_+\|dimethyl-sulfone-monooxygenase-SfnG	gnl\|CDD\|274923	TIGR04021, LLM_DMSO2_sfnG, dimethyl sulfone monooxygenase SfnG. This family of FMNH2-dependent members of the luciferase-like monooxygenase (LLM) family includes SfnG, a monooxygenase that converts dimethylsulphone (DMSO2) to methanesulphonate. This step can be followed immediately by methanesulfonate sulfonatase (an alkanesulfonate monooxygenase - see TIGR03565) for the FMNH2-dependent conversion an inorganic form. [Central intermediary metabolism, Sulfur metabolism].	0

>NZ_CP010989.1|WP_010229352.1|4311851_4313099_+|acyl-CoA-dehydrogenase-family-protein
MTTTENRSGTATVAEVVDWTAAPAPTDEAGWLRRAGEVRRILERDAAARDRAGATPYDEVALLKESGLVTLLGPVEHGGGGQEWPTAYRVIREVAAGDGSIGQLLGYHLLWFWAARLVGTPEQIEAVEADATRNRWFFGGAVNPRDSDLLIRDEGDEIVYNGRKSFSTGSTISDVTVLEGVLEGTDTHVFAIVPSEQDGIVFHDDWDNIGQRLTESGSVTITDVRVPWASAAGFTDKAFQPRVYNTLNVPTIQLVFVNFYLGIARGALETGARYTRTVTRPWLHGDAERAVDEPYQLDLYGDYRSKLWAVEALADAVAEEGLAIHRDAWNVTEEQRGEHEVRVAAVKARATDVALEITSGIFEGLGARATSAELAFDRFWRNVRTHTLHDPVAYKRREVGAHLLRDELPQPTWYT
>NZ_CP010989.1|WP_010229351.1|4310247_4311417_+|dimethyl-sulfone-monooxygenase-SfnG
MTDTTADNLDTTLNAQISEPLKFAYWVPNVSGGLVTSTIEQRTDWGFDYNVKLAQTAENNGFDYALSQIRYMASYGADHQHEATSFSLALGLATERLKVIAAVHPGLWQPAVLSKWIATADHLTKGRIAVNVVSGWLKDEFTSMGEPWLEHDERYRRTDEFIRVLREIWTAGDGGAEFAGDFYRVHGFDLKPKPVDVPGRPHPEIFQGGNSTAARRNGGRVSDWYFSNGKDYDGFTEQVEEVLGHAKTAPRLQPVRFGLNGFMIARDDEKEARDTLREIIEKANKPAVEGFRDAVQQAGNSTGDKRGMWADSSFSDLVQYNDGFKSQLIGTPEQIADRAIEYKRRGANLLLLGFLHFQEEVEYFGEKVLPIIREKEAELAAREPRPVTV
>NZ_CP010989.1|WP_060573586.1|4309641_4309983_+|HD-domain-containing-protein
MGFDAARALAETLLAHQRPELWVRAQRAAIRARELAEERGLDRDLLMTAAILHPVGHSPVVRRSGDPVRDAARFLGARGFDPRVVELVGGGADGPHAEALRTCADGQADPSGR
>NZ_CP010989.1|WP_060722234.1|4308234_4309632_+|GntP-family-permease
MENWTSPLGTGPLLGIALGAIVVLLVAIIRFKIHPLLALTVVSALTAFAARIPADAVLDVLVDGFGETLGEVALLVGLGAMFGRLAEVSGAAGALSDALVSRFGDRRAPFALGVASLLFGFPIFFDAAFMVMLPIIFTVARRVGGGVLVHTLPAAAALSTMHVFLPPHPGAVASTVLLGGDVGLVVLIGVLVAVPTWYLGAYFYSVWIGRRIVLPVPELLTGGPQTDDDETGPPPRPRVVVGLLLLPLVLIFANTLAATLADTGAVDPEAPWVVLPQFLGATPVALLITVLVATWVLATRRGRRAAFVEDLLDNALKPIAPVVFITGAGGMFGAVLIASGIGDALAGTLGATGLPVIVSVFLVAAILRIALGTATVTITTAAGLLGASVVEAGLGPVQTVAVVLALAAGSSIFPHVNDASFWLLGRLLGMDVPTTFKTWSVIKTLISLVGFALSCVVFVLASLAG
>NZ_CP010989.1|WP_060573583.1|4307058_4308066_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MTDTATGGPARPSRRAFCAGLAAGLVALATGAAAGCGGPEPVRGLRFLVPNAPGGGYDVTARSAAKALSDAGITGPAEVFSLPGAGGIAGLGRVVNEAGNDRLVLSMGLGLVGAARSTDATGLLTAATPLARLTRETEIVVVARDSPFRDLPQLLAAWRADPAGNAVGGGSSTGGPDHLATMLVAESAGVPPRRVGYVPHDGGGELLASLLADEVTFGVSGLGEFADQIASGALRILAITAGAPIPGVGAPTLREAGIDLEVTNWRGILAPPGLTPGQVGGLDDCFAAMVRTPQWQDVLRRNNWQDAYLPGPEFGTFLRSEDERVGRVLTGLGLG
>NZ_CP010989.1|WP_060573581.1|4305350_4306991_-|sensor-histidine-kinase
MGRRGGTRTPLARQFLVWQLVVVLVLLGAVAALAAVQSAESFRETQGRRMLSVAEDVASVPTVREALQRRQYDLLPSFARSAENLSGADEIEIVDAGLVVRTSPDPSRVRERFDPGASTAPAGRAWVGAPDGRTVVAQVPVIDDRGAVAGLVSAGIRAPSLWESLAGARTETVALLGLALGVGVAGSLLLARRVRRQTLGLEPGEIVELVQRREAMLLGIKEGVVGLDTADRITLLNPVARELLELPGARPGDPVADLGLDDRLREVLTGAAAGEDQLVLRDTRALVLNRMPVRLDGREVGAVVTLRDRTELTTLQHRLDASHTVTDTLRAQAHEFSNRLHTIAGLTELGEHEEVRRFVAGIVAASEGWRREVSSRVGDAATAALLVAKNSRAAERGVELTFDPDSRLEPTDPERDPDLSADLVTVLGNLIDNAVDATAGRSGERRVQIGLSGGGDDDGGEVWIEVRDSGPGVASELAEEVFRAGFSTKAAEIGGRGLGLALARQACLRRGGMIAVQDAAEGTGAVFVAVLPVAGKPATTGEEVQR
>NZ_CP010989.1|WP_060573579.1|4304658_4305354_-|response-regulator
MRVLVVDDDFMVAKVHSGYVERIEGCTVVGVAHRGAEALERAAELRPDLVLLDVYLPDMSGIEVLRGLRTGAADDPFVLVVTAADDPDTVAAALHGGALHYLVKPFDSAALAAQVHRARRLRRDLDRVRGQSDIDRLFGGTGGMPAGSAGGPERMPKGLTTPTADLVARTLREHTGAGDADLSATECAEATALSRVSARRYLEHFVTTGTATVRLRYGGTGRPERRYRWVG
>NZ_CP010989.1|WP_060573577.1|4303768_4304677_+|alpha/beta-fold-hydrolase
MEREVEIEPGVTLWVEDLPAHRETPAHPVLLVMGANASGIGWPDALVELLRERHRVVRYDHRDTGRSSHAFEDHPYGIADLAGDALTVLDACGIGRAHVVGMSMGGVLVQLLALDAPDRLASAALLCTAALGADLAGLPGPPRDVLRMWQEMHDPRDERSELAWRVEHWRRLSGGALPFEPAEFEELERRVMAHSGRVEAPTAHAQADPGGLDRGDELGSITVPTLVVEAPADPVNPPPHAAFLAERIAGRRAAPPVRLVSIEGMGHALPSAVLEPLAWELLEHAAEAEDEAAGAPGQPTQR
>NZ_CP010989.1|WP_010236095.1|4303320_4303632_+|hypothetical-protein
MALPTLTPEQRAEALKKAAAARTARKELRDKIASGEETIPGVLGRAKTDQIVGKTKVADLLKSVPGWGPAKVSKVMEEAGIDASRRAAGLGERQRQALIEKVG
>NZ_CP010989.1|WP_145982682.1|4302640_4303084_+|nuclear-transport-factor-2-family-protein
MTPAMQTLMRDVARLWDDAADGLYDRGDPAPATAVLGDGVVWTELPTGAGGTGPDAMGGHLAVVAASLPGGGTRTRLSRTLDVRRIADEVRFAFTHDHELPWLLPGVAPTGRRVEVHAVQLVRVRQGRIDELRTLWDVAGLRTTLGF
>NZ_CP010989.1|WP_060722235.1|4313464_4314286_-|NAD(P)H-binding-protein
MTILVTGATGNIGRLVVDHLIARTGEPVRALTVDPARAALPDGVEAVRGSVRRPAALDGAFDAVRAMYLAPYEPTAAEVLASAADAGVEHVVALTGEPDSWWGTVTKAVEAAGPAWTHLWPADFVENYEMWLPQIRATGVVREPWPALASTPTAMTDIAEVAAVALTAPGYTGRALTLTGPEPVSRRDAVAAIAEATGVGIGFEQVTPDEAVAALEPSAGRDAAEMVVHTILGFLHDAEPAPNGVVEEVTGRPATTVAAWAHSHADRLRAAIT
>NZ_CP010989.1|WP_050802561.1|4314377_4315688_-|TMEM165/GDT1-family-protein
MDGFLAAFAVSFGVIFVAELGDKSQLMALTFATRFKAIPVLVGITIATSVTHLVSVAVGYGLGASIPTGWIALVASVAFVAFGAWTLRGDSLTDDEEQKAKRAGGSAVVAASVAFFLAELGDKTMLATITLATQYSWFGVWLGSTLGMVAADALAIVVGRKLGQKLPERVISVGAAIMFFVFGAWLFAEAVPQVWGDDAWARLADAMGHQGFGWAALALGLVAVGTGLVVRGRAHRARGERRLDVARAPGSPAWWARTLFVVAAVLGFGAPLLVALDVLEPISVLSRPAVAVVGAGLLLLGFAVVAVAMLQLGTVWRRSATEAGAAAAGDPDAARRPVLATGGLYRRVRNPALTGLIVGCAGMLFMAPTLLGVLAGVLILVAVQIQARAVYEPGLGSALGPEYDAYRLRTGRFLPRVRRTGADGDATAGDDHTRVG
>NZ_CP010989.1|WP_010242245.1|4316008_4317175_+|thiolase-family-protein
MPEAVVCEAVRTPIGKRKGSLSEVHPVDLSAAVLTALAERTGIDPGVVDDVVWGCVNQVGDQAAQIGRYALLAAGWPETVPGVTINRACGSSQSAFDFAAGMVLAGQYDVVVAGGVESMTRVPLGAGRELGRPYGPLVRDRYREDLTSGEFPNDDFNQGVGAERIARDWGLSRTRLDEYAARSHELAAAAIDSGAFDGQLVDVPGAPGFAADEGLRRGTTAETLAALKPVFSGTGVIHAGNSSQISDGASAVLVTTPERAAELGLTPIVRYHSGAVSGADPLRMLTGPIPATQKVLKRSGLAIGDIGAFEVNEAFAPVPLAWQAELGADDARLNPLGGAIAVGHPLGASGTILLTRLVHHMRDRGIRYGLQTMCEGGGTANATVVELV
>NZ_CP010989.1|WP_060573589.1|4318044_4319544_+|trypsin-like-peptidase-domain-containing-protein
MTEYGPGTGGRADGETSTGGGATDPTRPDPRAAGDGPGHADGRSAQEATDVTDTDHRRQQEQAPPPWASASNPTIPAHGAGSPPTSVYPPFPAQAPAPKPPRRFGAGLVTVAVAAGLVGGGVGFGGAYAVLGGDTGSSTATLSSSAAPGTPAQAADGSIAGAAAAITPSTVDIQVRTAQGTAEGSGVILTADGEVLTNNHVVSGAGDGGQITVSTADGTQHRATVVGTSPSYDLAVIRLEGASNLKAATLGQSSGVQVGEQVVATGSPQGLSGTVTAGIVSALNRTVSASGDGGTPVVYNGLQTDAPINQGNSGGPLVNLAGQVVGINSAIATSGQNAGSIGLGFAIPVDTAKRVAQELMSDGVATKPQLGVQGSVSASGSETAGTGGAQVAAVEPGSPAANAGVAAGDVVTKVDEYPVSSFADLIARVGNFTPGQQVTLTIGSGADARQVPVTLGSAQDTEAATARQGALTTPEGSGQGGGSAPSAPFGINPFGGGGN
>NZ_CP010989.1|WP_060573591.1|4319742_4321125_+|sugar-porter-family-MFS-transporter
MTTHGDTGDTGHRTRQGRGIGLATTVAAAGGLLFGYDTGVISGALLFIAPEFGLGEAGQQLLVSGLLVGALVGALAGGAITDALGRRRTLVGVAAVFLLGAVLSGLAPGTGVLLGARVLLGLAIGVSSVCVPLYIAEIAPKESRGRLVSMNQFLITVGILLSYLVNSLFAEAESWRWPLLLAGVPALAMLVGLAGAQESPRWLVLRGRVDEARAALAGRTPEQADAEIAEIRAAARDEARWTWSDLRRPQLRPALTLGIGVAAVNQLVGVNAVIYYAPTILSGVFGSDTGALLATVGIGVVNTVVTAVALARIDSWGRRPLLLGGLAVVVAALVALVVLFLLPSQDGIVGVLVVVALCVYIAAFAASLGIAIWLVNSEVFPTAVRGKAAGLGATTHWGIDLVIASTTLTLITTLGESGLFAIFAVIGVAGFVFLHRLMPETKGRSLEEIDAALQERAGRT
>NZ_CP010989.1|WP_060576278.1|4321134_4321761_-|hypothetical-protein
MSPDAGRVAYLVVGGGVLFGSILPVVPTGAIVGAAAATAMTSPALSLPVVLVLAFAAALAGDLVTYAVARRGSVPVLDAVAGGRFGGARTGERVARVRAAFADRGWLLVLVGRVAPAGRVPTLIAAAASGMAWSVLLPAVAAGAVLWTLLYGVLGVLTGNLTDSPLVAAGLAVGLVAVVGAVTALVGRLRSRRRERRAHSPGEPAHDR
>NZ_CP010989.1|WP_060573592.1|4321814_4322615_-|MBL-fold-metallo-hydrolase
MDLPETTFLGHSTLRLRLGGRTVLTDPVLTSAVGPLRRMAPAVDPAGLDGVDLVLISHLHADHLHLGSLALLPRDTEVVVPAGAAAWLRRRGVARVSELAVGQRRTFGGLHVTGTPADHSGHRWGPRLTHGPQADAMGHLLEGDGLRVYAAGDTGLFPGLGDVAAQGPIDLAALPVWGWGPSLGPGHLDPAGAAEAVRRLAPRAALPVHWGTLAVTGLCSVPGRTGGRMRELLVRPPHDFAAAVAAAGPPARTLVVPPGAAVGAAV
>NZ_CP010989.1|WP_060573593.1|4322650_4323061_-|TIGR03618-family-F420-dependent-PPOX-class-oxidoreductase
MTRRRSLSDGVSDRFRELWSERRPCVLVTPRRDGTPHAVPVGVTVDVEDGIARVLSSGGSQKARNVAAAGPDGARVTVTAVDGRTWSTLEGVAVVDPTPEGVHAAERRYAAEYKEPRVNPQRVVLRIVVDRVLGNA
>NZ_CP010989.1|WP_060722236.1|4323071_4324286_-|helix-turn-helix-domain-containing-protein
MEFLNAAETAERLGVKRETVYAYASRGLLTSVRGAQRRGSRFAQDEVEALAARGREAGEPSGAVERIRTRITLVADGGPWFRGVPVGELAVAGTLGDAAAVLWETPGPVAFDADPALLPVARGALAALPGGARTTDRFRVAVAALAAADPLRADVAPAAVVRTASGLLGTVVDALAGGGDGPLAARLWPALARDPDGEPPPAALDHVRAALVLLADHGLAASTVAARVAASTLADVHAVVSAGLGALDGPRHGLASGLAHRFLAGALDDPRGALAERLRAGERVPGFGHTVYRGPDPRATVLLDRLRDDPAAERVLACVDAVAGDLDRGGEGPAPNVDLALAALLHAHGLRRDAGELLFATARTVGWVAHAREEYAEPGLRFRPSGVYTGPRPGSREHPPGTAG
>NZ_CP010989.1|WP_060573595.1|4324365_4325529_+|citrate-synthase/methylcitrate-synthase
MTTTERAAVPEVPPGLRGVAVTTTTLGDVRGDEGFYHYRQYSAVELARTRTFVCAWFLAARGRLPDPDERAAFAARIAQRRALPAALSALLPGIAAACGDDLLAGLRAALSVLGPLHGMRPVWDAGPERGADDALTVCAATPTILAALHRLRSGLDPVPPRPDLEPAADWLWMLTGAEPDPGHARAVDAYLVSTLDHGFNASTFTARVVASTGADVASAVTAATGAFSGPLHGGAPDRALEGLDAIDRDAGGSPERWVADRLAAGERIMGFGHAVYRGPDPRTALLREVAERLGGPLPARAADVERRVAATLAELRPDRPLHANVEFYAGVVMAGCGIPRSMFTPTFATSRVVGWCAHVLEQAEQRRLIRPSATYVGPPPPEPVPPR

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Crispr_ID: NZ_CP010989_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010989_5

4480946-4481104

Orphan

Consensus_repeat	Method
GGCCTTCTTCTCGGCCTTGGC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP010989_5

>merge|NZ_CP010989|5|4480946-4481104|PILER-CR
GGCCTTCTTCTCCGCCTTGTCCGCCTTCTCGCGCTTCGCGACCTTCTCGAGCCGGGCGGCCTTGGCCTGCTTCGCGGCCTTCTTCTCGGCCTTGGCGGCGTCCTTCTGGGCCTTGCGCTGCTCGTCGGCCTCGGCCTTGGCCTTCTTCTCGGCCTTCGC

>NZ_CP010989|5|1|4480946-4481104|PILER-CR
GGCCTTCTTCTCCGCCTTGTC	CGCCTTCTCGCGCTTCGCGACCTTCTCGAGCCGGGCGGCCTTGGCCTGCTTCGC
GGCCTTCTTCTCGGCCTTGGC	GGCGTCCTTCTGGGCCTTGCGCTGCTCGTCGGCCTCGGCCTT
GGCCTTCTTCTCGGCCTTCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010989.1\|WP_010228973.1\|4474114_4474918_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349977
NZ_CP010989.1\|WP_010232861.1\|4476222_4477038_+\|crotonase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|235714
NZ_CP010989.1\|WP_060573761.1\|4487497_4487914_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_082399110.1\|4481737_4482571_-\|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274373
NZ_CP010989.1\|WP_010224581.1\|4479588_4479891_-\|energy-coupling-factor-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|179494
NZ_CP010989.1\|WP_060722259.1\|4482753_4483170_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NZ_CP010989.1\|WP_050802195.1\|4486631_4487483_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176125
NZ_CP010989.1\|WP_010224644.1\|4489036_4489798_-\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|187629
NZ_CP010989.1\|WP_010224586.1\|4483200_4483344_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_060573755.1\|4478009_4478861_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|184199
NZ_CP010989.1\|WP_060573762.1\|4487856_4489008_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173849
NZ_CP010989.1\|WP_060573753.1\|4472912_4474079_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP010989.1\|WP_082399109.1\|4477195_4478005_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|252734
NZ_CP010989.1\|WP_060573751.1\|4472251_4472929_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP010989.1\|WP_139323790.1\|4474971_4476147_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP010989.1\|WP_010224582.1\|4479887_4480595_-\|energy-coupling-factor-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|181384
NZ_CP010989.1\|WP_060573760.1\|4484516_4485677_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NZ_CP010989.1\|WP_060573759.1\|4483585_4484470_+\|MaoC-family-dehydratase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|226300
NZ_CP010989.1\|WP_010224589.1\|4485673_4486522_+\|CoA-ester-lyase	unknown	unknown	gnl\|CDD\|225184
NZ_CP010989.1\|WP_060573756.1\|4478857_4479589_-\|cobalt-ECF-transporter-T-component-CbiQ	unknown	unknown	gnl\|CDD\|274139

Protein	Function_ID	Function_description	E-value
NZ_CP010989.1\|WP_010228973.1\|4474114_4474918_-\|RNA-methyltransferase	gnl\|CDD\|349977	cd18104, SpoU-like_RNA-MTase, SAM-dependent RNA methylase related to SpoU-TrmH. RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	1.86883e-62
NZ_CP010989.1\|WP_010232861.1\|4476222_4477038_+\|crotonase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|235714	PRK06142, PRK06142, crotonase/enoyl-CoA hydratase family protein.	3.17268e-119
NZ_CP010989.1\|WP_082399110.1\|4481737_4482571_-\|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274373	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. This group of similar sigma-70 factors includes clades found in Bacilli (including the sporulation factors SigF:TIGR02885 and SigG:TIGR02850 as well as SigB:TIGR02941), and the high GC gram positive bacteria (Actinobacteria) where a variable number of them are found depending on the lineage.	1.71465e-101
NZ_CP010989.1\|WP_010224581.1\|4479588_4479891_-\|energy-coupling-factor-ABC-transporter-substrate-binding-protein	gnl\|CDD\|179494	PRK02898, PRK02898, energy-coupling factor ABC transporter substrate-binding protein.	1.09794e-38
NZ_CP010989.1\|WP_060722259.1\|4482753_4483170_+\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	1.19707e-22
NZ_CP010989.1\|WP_050802195.1\|4486631_4487483_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176125	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold. GltC, a member of the LysR family of bacterial transcriptional factors, activates the expression of gltA gene of glutamate synthase operon and is essential for cell growth in the absence of glutamate. Glutamate synthase is a heterodimeric protein that encoded by gltA and gltB, whose expression is subject to nutritional regulation. GltC also negatively auto-regulates its own expression. This substrate-binding domain has strong homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.26139e-75
NZ_CP010989.1\|WP_010224644.1\|4489036_4489798_-\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|187629	cd05371, HSD10-like_SDR_c, 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs. HSD10, also known as amyloid-peptide-binding alcohol dehydrogenase (ABAD), was previously identified as a L-3-hydroxyacyl-CoA dehydrogenase, HADH2. In fatty acid metabolism, HADH2 catalyzes the third step of beta-oxidation, the conversion of a hydroxyl to a keto group in the NAD-dependent oxidation of L-3-hydroxyacyl CoA. In addition to alcohol dehydrogenase and HADH2 activites, HSD10 has steroid dehydrogenase activity. Although the mechanism is unclear, HSD10 is implicated in the formation of amyloid beta-petide in the brain (which is linked to the development of Alzheimer's disease). Although HSD10 is normally concentrated in the mitochondria, in the presence of amyloid beta-peptide it translocates into the plasma membrane, where it's action may generate cytotoxic aldehydes and may lower estrogen levels through its use of 17-beta-estradiol as a substrate. HSD10 is a member of the SRD family, but differs from other SDRs by the presence of two insertions of unknown function. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.15864e-138
NZ_CP010989.1\|WP_060573755.1\|4478009_4478861_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|184199	PRK13639, cbiO, cobalt transporter ATP-binding subunit; Provisional.	1.68394e-87
NZ_CP010989.1\|WP_060573762.1\|4487856_4489008_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	1.96207e-161
NZ_CP010989.1\|WP_060573753.1\|4472912_4474079_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.47748e-35
NZ_CP010989.1\|WP_082399109.1\|4477195_4478005_-\|SAM-dependent-methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	2.20933e-63
NZ_CP010989.1\|WP_060573751.1\|4472251_4472929_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.72478e-68
NZ_CP010989.1\|WP_139323790.1\|4474971_4476147_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.71718e-23
NZ_CP010989.1\|WP_010224582.1\|4479887_4480595_-\|energy-coupling-factor-ABC-transporter-permease	gnl\|CDD\|181384	PRK08319, PRK08319, energy-coupling factor ABC transporter permease.	1.76475e-118
NZ_CP010989.1\|WP_060573760.1\|4484516_4485677_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	1.82839e-138
NZ_CP010989.1\|WP_060573759.1\|4483585_4484470_+\|MaoC-family-dehydratase-N-terminal-domain-containing-protein	gnl\|CDD\|226300	COG3777, COG3777, Uncharacterized conserved protein [Function unknown].	2.38495e-53
NZ_CP010989.1\|WP_010224589.1\|4485673_4486522_+\|CoA-ester-lyase	gnl\|CDD\|225184	COG2301, CitE, Citrate lyase beta subunit [Carbohydrate transport and metabolism].	6.5255e-64
NZ_CP010989.1\|WP_060573756.1\|4478857_4479589_-\|cobalt-ECF-transporter-T-component-CbiQ	gnl\|CDD\|274139	TIGR02454, Uncharacterized_protein_MJ1089, cobalt ECF transporter T component CbiQ. This model represents the CbiQ component of the cobalt-specific ECF-type. CbiQ is now recognized as the T component of energy-coupling factor (ECF)-type transporters. The S component confers specificity (CbiM-N for cobalt systems), which CbiO is the ABC-family ATPase. In general, proteins found by this model reside next to the other putative subunits of the complex, identified as CbiN, CbiO, or CbiM. Note that the designation of cobalt transporter has been spread excessively among ECF system transporters with many other specificities. [Transport and binding proteins, Cations and iron carrying compounds].	8.32786e-31

>NZ_CP010989.1|WP_010224582.1|4479887_4480595_-|energy-coupling-factor-ABC-transporter-permease
MHIAEGYLPPLHAAAWTVVAAPFVVHGARAVVVRVREDPDTKLLLAAAGAFTFVLSALKIPSVTGSSSHPTGTGLGAVLFRPPVMALLGTVVLFFQAVLLAHGGLTTLGANAFSMAIAGPWIAYGAYVLVRRLGGGLGPAVFAAAFLGDLGTYTITSAQLALAFPDPTSGFGGAFVTFASIFSLTQIPLAVAEGLLTVLVVRLLVRITPDELRRLGVLRPKDTAGDGAASKEASA
>NZ_CP010989.1|WP_010224581.1|4479588_4479891_-|energy-coupling-factor-ABC-transporter-substrate-binding-protein
MSRSTLVNVLLVVAVVALFAIPVLFVPGEYSGADGQAGEAIEASGYEPWFSPVWEPPSGEIESGIFALQAAAGAGVLGYCLGVARTRSRQRGADSAPTET
>NZ_CP010989.1|WP_060573756.1|4478857_4479589_-|cobalt-ECF-transporter-T-component-CbiQ
MLLIDEIAHANRWRGRHPGEKAFLALGLLVLAVALPPWPGALLTGTAAVALLLAGARVRPGTALRLLRLPLGFVLVGALPLLVTLGGDPWLALAPGGPARAAELVGRSMAAVGCLILFAATTPLADTLPRLRFVPPAVLEITLLIYRMLFLLLDSLNAVREAQSLRVGFRTRRATFRSLAGQGSAVFVRAFDRARRLEAGLASRGYDGSLRVRVTSRPVSPRFVAASAALLVAVGATALAVRA
>NZ_CP010989.1|WP_060573755.1|4478009_4478861_-|ATP-binding-cassette-domain-containing-protein
MTAPVLEARGVAFAYRDGPPVLDGADLAVRTGRRLAVLGPNGGGKTTLFRLLLGLLEPARGEVLLDGAPLDRSRRGLARLRESAQLVLQDPDDQLFAADVAQDVSFGPLNLGLPDAEVDARVGEALAAVGMAELADRPTHRLSFGQRKRVAIAGALAVRPRILVLDEPTAGLDPAGVEELVAVLGRLHDEGTAVVLSTHDVDLAHRWADDVAVVHDGRVRRGPSAEILGDTGLLAAARLGPAWAPAVARLLAAAGHPGPAPRTAAELHDVLTALALREEIARG
>NZ_CP010989.1|WP_082399109.1|4477195_4478005_-|SAM-dependent-methyltransferase
MIDPDRAGGPDLSLPNPARVYDYMLGGAHNFDADRAFAERLLEALPGARDAAVANRAFLGRAVRACLDRGCRQFLDLGSGIPTAEPLHEIVRRHDPAARVAYVDSEPVAVAMSREILDGVDGVTISAADLTDADAVLAAPDVADLFDPTVPTAVLAVSVLHFVRDDAVLTRLLDRYCDAFGPGGLLVLSHGSTDVDDERAAEEMRTIERFTQESAQPAAARDRATLRRLLHRVDLLEPGLVDVSRWRPEPGHEPGRVVGMYAAVGEIVH
>NZ_CP010989.1|WP_010232861.1|4476222_4477038_+|crotonase/enoyl-CoA-hydratase-family-protein
MGEPTGIAVEVADGVARLRLDRAEAANALNEPMWFGLRDALRALDDDPAVRVVVISGNGRHFCSGIDVAMLGGLKETAADDSPGHGADRLRRVILDLQECLTAVERCRTPVIAAVHGVCLGAGLDLAVACDLRYATADASFVLKEVDMGLAADVGVLQRLPRIVGEGVAREMAYTCRPVSGTEARELRLVNGVYDDAAALEEGVAGLAAELAAKSPLAMRGTKYAITYARDHTVADSLDQIATWNGGQLVSADLQEAVSAFLEKRPGTYRD
>NZ_CP010989.1|WP_139323790.1|4474971_4476147_-|MFS-transporter
MRQRGAGDRTWWVACGLLFATAFGTNVPTPLLLVYRTELDLAPSTLAAIFGVYALGLAPSLLLGGPASDRFGRVRVLLPASVGVVLASLLFLGGASALWLLFAARFVQGLASGAVFSVGSAWLQDRAGADGAGRAARAASVAQTAGFCLGPLASGLLAAYGPLPLTLPYLVHVGLLVVAVAAVLVTVGTGSPPVGVVPRGLLPRPGFDPAARRTFVRVVVPTAVCVYAFPSVSVTVLPLLLPGASGLVAFTGLLAALTLGTGTLVQPFAHRPGARAGALGAALGALGFATGVVAALTGSVVAVAVAGILLGAGGGLCLNAGLTLVGRLAPASGRGAANGVFYTAAYLGFATPFLVTASAPVQALAVPLAVLVAVTVATAAWLAARAGDTAS
>NZ_CP010989.1|WP_010228973.1|4474114_4474918_-|RNA-methyltransferase
MPDLTSTANPRVKNLVRLRTRRHRDAAGVTLVEGHDELSLALDAGVRPTEVYWAPDLVRSEELLERMPGARATSVTREVFARIAYRESPDGWLAVAPAPGRPLDELELRPDALVLVAEGIEKPGNVGAMLRTAEACGVDAVVIATPDRAGTDFANPNVVRASKGTVFAVPVASAPTAEVQEWLRRRGVRSVVTTPAGTTELGRADLTGPTALVIGTEATGVTGPWLAGADATVVIPMRGTVNSLNASIAAAVVLFEAVRQRSGTSAG
>NZ_CP010989.1|WP_060573753.1|4472912_4474079_-|sensor-histidine-kinase
MPTVRDVLVALVVGAAAVAGALFADPSGRPLLPWGAVLIALATLLLCWRSRHPVPVLVAVMVPTALYYWLDHPDGPASLLVAVAVYTVASRVSWPHAVLTGVLVVLAWTGTEQLIVGPPPELHLDHYSWIVVTVALGVAVGAVRRAAEASAGRAEERLVRRVEQERLRIARDVHDVVSHSLSMIVVQAGVGAHVAARRPEEAVAALERIRDAGTDALRELRGTLALLRDPADPGADPGDGDGTAPDRHAGGLDRLDEVVRAGRAAGITVTVAGDAGALPPEVDRAAFGTVREAVTNTVRHAPDASAARVTLDRHGDLLHLRISDDGGPPAPAGERGRPEGQGLRGLAERAAALGGRCTAAPDGDGFVVTAELPVAIRTTPAAGGAAGA
>NZ_CP010989.1|WP_060573751.1|4472251_4472929_-|response-regulator-transcription-factor
MRRVPDVRVLLADDQPLIRAGLRVLLETEDGYAVAAEAADGAEAVRRARETRPDVALMDVRMPGTDGLDALSAITGDPELAGTRVIVLTTFDLDDYVYRALRSGASGFLLKDTDPVALLRAIDLVHAGEALLAPSVTRRLITEFARHGPAAPPGTDRLAVLTGREREVLALVGRGHTNGEIAAQLVISPATARTHVGRLLTKLGARDRVQLVVIAHETGLVGQRR
>NZ_CP010989.1|WP_082399110.1|4481737_4482571_-|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor
MAEPDTRMDTATVATDDEYAHLDAPLRAFAAAPGDDPERAALREQLARGFHPVVRHIAGRYRHRGEPADDLEQVGAIGLLNALDRFDPEQGTPFLAYAVPTITGEIRRHFRDRTWSMRVPRRLKDFQTRMTRAQEELAVRHGRAPKVSELAEHLGTSREEVIEGLQAQDSYRSDSLDRLAGDTESPLGEIVGGADAGIGTVEDREALRPALRRLPERERTILLLRFFGNRTQTQIAEEVGLSQMHVSRLLARSLATLRRHLVEEPGGDSVSPMSDAG
>NZ_CP010989.1|WP_060722259.1|4482753_4483170_+|ATP-binding-protein
MGPRLHVELPADPGAAGRSRRETGRWLTSLCGADRPCETAQDLVLAVNEAVSNCVEHGYRAAPSGTVSLRGTADGARVRMEISDRGSWREPPEDNGCRGRGLGMVEAVTEDVRVERGPGGTTVTFHGTLGRCPGVCSD
>NZ_CP010989.1|WP_010224586.1|4483200_4483344_-|hypothetical-protein
MSESSTQHADAGWPHPASEAARLDGRYSPDRTGAPTRLTDDAGIHRD
>NZ_CP010989.1|WP_060573759.1|4483585_4484470_+|MaoC-family-dehydratase-N-terminal-domain-containing-protein
MPETAATGVLADLVRDWDPPQVTDSRRVDPWPAAAFADLLDAPVPDLRDGAALPPMWHWLLLLPHPRTSEIGEDGHPTDGPFLPPVPGRRRMFAGGRFHAHGTIPFGSVLGSRSSVTTVTPKSGRSGEMLFVTVRHELTVDGGDDVVAVEEQDIVYRSEPEGTERRVVERPVADQPDPGGAWRLRRPTDSVLLSRFSALTYNGHRIHHDLPYVTGVEGYPDLVIHGPLMALLALELPRQNAPSDRVTGFEYRLARPAFVPSALVATGDRSGAEATVAVAAEGVQPSLTATVHLG
>NZ_CP010989.1|WP_060573760.1|4484516_4485677_+|acyl-CoA-dehydrogenase-family-protein
MGVLSTEEQAVVDVVRDFVDREVKPSVNEVEHSGEYPEKWIEQMKELGIYGLAVPEPWGEAPVSMPCYALVTAELARGWMSLAGAMGGHTVVAKLLVEFGTQEQKDRYLPRMATGELRATMALTEPGGGSDLQNMATHAAPDGDGYVINGSKTWISNARRSGLIALLCKTDPAAEPKHRGISVLLVEHGPGLTVSKDLPKLGYKGVESCELIFDDMRVPAGAVLGGTPGRGFGQMMKGLETGRIQVASRALGVADAALEDSLRYAQDRESFGKPIWQHQSVGNHLADMATKITAARQLILYAAQKYDRGERCDMEAGMAKLFTSEIAMEVALNAVRIHGGYGYSTEFDVERYFRDAPLMIVGEGTNEIQRNVIAAQLVKRGGLERG
>NZ_CP010989.1|WP_010224589.1|4485673_4486522_+|CoA-ester-lyase
MTDTTTDTGYTLRGPALLFCPGDRPERYAKAAAAADTVILDLEDAVGPDGKDAARAAVVAGLAELDPAAVVVRVNAPGTAWHDADVAALAGHPDVAVMLPMAARAADVAALAPRPVIALCETAAGVLAAPEIAAAPNCTGLMWGSEDLVADLGGRPGRAPGGGYRPAVEEARIRILYAARAAGVTPVDTVLVAIDDLDTLRTDSESAVGSGYAAKACIHPKQVTVVREAFLPTDDEVAEAREVLDAAREHTGGGVFRLHGRMIDAPVLAHAREVLRQAGAPV
>NZ_CP010989.1|WP_050802195.1|4486631_4487483_+|LysR-family-transcriptional-regulator
MTRAAEKLSVAQPTLSRALGRLERQVGAPLFDRVARRLRLNASGEIMLEHARRSLAELAAAGDRIATLRDPDHGTVRLAFLHSIAAGLTPEMLRAYRSHAPGVVFELTQAAGHEIIEHVRAGRADLGLTAPRPDDDELAWTGLYRQQLCLAVPADHRLAGRPRVALSAAGTDPFVALRAPIGLRRLTDELCARAGLSPRFAFESTEIGTLEGFVSAGLGVAIVPEPRPDRAEPGVSYVPLTDATAHRSIGLTWLRERPAPPVVARFADFVVERYRDRAPGTRP
>NZ_CP010989.1|WP_060573761.1|4487497_4487914_+|hypothetical-protein
MPDDPTTIPLGHDELRAVTAFAVACARPALEIVEHACPGDPRPRDAVDAAHAFAGGADRTRATRDAAWAAHRAAQETRDAGLAAASDAARAAGHAAGADGSASWSGDWTRRSGDAAVPGPQSPRPRPMTSFMISVVPP
>NZ_CP010989.1|WP_060573762.1|4487856_4489008_-|acyl-CoA-dehydrogenase-family-protein
MRRTLYESDHEDFRSAFRAFVDKEVAPHGERWTADGIVPRELFTTAGANGFLGMDVPESYGGGGVPDFRFNAVVIEELMDAGAGGLGLGMTLHNDIVIPYLLAYGSDEQKQRWLPDAVSGNAILAIAMTEPGTGSDLASMTTTAVREGDHYVVNGSKTFITNGINADLVVVAVKTDPSQKHKGMSLLVLERGMEGFERGRNLDKLGQHAQDTAELSFTDVRVPVGNLLGPDEGQGFTQLVTNLPQERLSIAVAGVAAARTALTQSLEYVKERKAFGSPIGSFQNSKFVLAELDTEIDIAEHYVDDCVRALNAGELTAVDASKAKYWCTELQGRVVDKCLQLHGGYGYMSEYPISTAYADARITRIYGGTTEIMKEVIGRGLGL
>NZ_CP010989.1|WP_010224644.1|4489036_4489798_-|3-hydroxyacyl-CoA-dehydrogenase
MDINGSVAVVTGGASGLGLATTEKLVEQGGKVVIIDLPSSQGEAVADKLGDAVRFVPADVTDEAQVGAALDAAEELGTVRIAVNCAGIGNAAKTYGKKGAFPLDGFTKVINVNLIGTFNVIRLAAERIATAEPVDGDRGVVINTASVAAFEGQIGQAAYSASKGGIVGMTLPIARDLADLGIRVCTIAPGLFETPLLGALPEDVKASLGKQVPHPSRLGQPAEYAKLAAHIVENPMLNGETIRLDGAIRMQPR

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Crispr_ID: NZ_CP010989_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010989_6

4742344-4742498

Orphan

Consensus_repeat	Method
CCCGTACGTACATACCGGAAGGGG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP010989_6

>merge|NZ_CP010989|6|4742344-4742498|CRISPRCasFinder
CCCGTACGTACATACCGGAAGGGGAAAGAATTTTTCTCCTTGATGTGAGCACATGCTCATGCTCACCCGTACGTACATACCGGAAGGGGTCGGAGGTTCCCGAGCCCTTTGTGACCAACCCCTTGCGGTCACCCCTACGTACTGGTTAGAAGGGG

>NZ_CP010989|6|5|4742344-4742498|CRISPRCasFinder
CCCGTACGTACATACCGGAAGGGG	AAAGAATTTTTCTCCTTGATGTGAGCACATGCTCATGCTCA
CCCGTACGTACATACCGGAAGGGG	TCGGAGGTTCCCGAGCCCTTTGTGACCAACCCCTTGCGGTCA
CCCCTACGTACTGGTTAGAAGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010989.1\|WP_082399135.1\|4742619_4743168_+\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|372608
NZ_CP010989.1\|WP_060721787.1\|4746656_4748108_-\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|366234
NZ_CP010989.1\|WP_145982836.1\|4741070_4741544_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271175
NZ_CP010989.1\|WP_050802359.1\|4733029_4733980_+\|D-2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240625
NZ_CP010989.1\|WP_060576312.1\|4748171_4748780_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_060633589.1\|4734078_4735488_+\|amidase	unknown	unknown	gnl\|CDD\|180437
NZ_CP010989.1\|WP_060573899.1\|4735522_4735987_-\|Sec-independent-protein-translocase-subunit-TatB	unknown	unknown	gnl\|CDD\|179538
NZ_CP010989.1\|WP_060573909.1\|4745851_4746664_-\|ExeA-family-protein	unknown	unknown	gnl\|CDD\|225806
NZ_CP010989.1\|WP_145982696.1\|4748868_4749624_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_145982695.1\|4744840_4745287_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_060721796.1\|4751717_4753013_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NZ_CP010989.1\|WP_145982697.1\|4750744_4751725_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226974
NZ_CP010989.1\|WP_010241558.1\|4738336_4738972_-\|RNA-polymerase-sigma-factor-SigE	unknown	unknown	gnl\|CDD\|236606
NZ_CP010989.1\|WP_060573903.1\|4741747_4742104_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_145984032.1\|4744349_4744763_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_145982693.1\|4743508_4744066_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010989.1\|WP_060722282.1\|4739233_4739833_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|234698
NZ_CP010989.1\|WP_060573901.1\|4737686_4738340_-\|zf-HC2-domain-containing-protein	unknown	unknown	gnl\|CDD\|274904
NZ_CP010989.1\|WP_060573900.1\|4736037_4737594_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP010989.1\|WP_060721796.1\|4739889_4741185_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151

Protein	Function_ID	Function_description	E-value
NZ_CP010989.1\|WP_082399135.1\|4742619_4743168_+\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|372608	pfam13455, MUG113, Meiotically up-regulated gene 113. This is a family of fungal proteins found to be up-regulated in meiosis.	4.11987e-06
NZ_CP010989.1\|WP_060721787.1\|4746656_4748108_-\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	2.05872e-28
NZ_CP010989.1\|WP_145982836.1\|4741070_4741544_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.72645e-09
NZ_CP010989.1\|WP_050802359.1\|4733029_4733980_+\|D-2-hydroxyacid-dehydrogenase	gnl\|CDD\|240625	cd05300, 2-Hacid_dh_1, Putative D-isomer specific 2-hydroxyacid dehydrogenase. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomains but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric. Formate dehydrogenase (FDH) catalyzes the NAD+-dependent oxidation of formate ion to carbon dioxide with the concomitant reduction of NAD+ to NADH. FDHs of this family contain no metal ions or prosthetic groups. Catalysis occurs though direct transfer of the hydride ion to NAD+ without the stages of acid-base catalysis typically found in related dehydrogenases. FDHs are found in all methylotrophic microorganisms in energy production and in the stress responses of plants.	2.97747e-120
NZ_CP010989.1\|WP_060633589.1\|4734078_4735488_+\|amidase	gnl\|CDD\|180437	PRK06169, PRK06169, putative amidase; Provisional.	0
NZ_CP010989.1\|WP_060573899.1\|4735522_4735987_-\|Sec-independent-protein-translocase-subunit-TatB	gnl\|CDD\|179538	PRK03100, PRK03100, Sec-independent protein translocase subunit TatB.	2.86237e-52
NZ_CP010989.1\|WP_060573909.1\|4745851_4746664_-\|ExeA-family-protein	gnl\|CDD\|225806	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion].	7.48269e-79
NZ_CP010989.1\|WP_060721796.1\|4751717_4753013_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	2.81815e-60
NZ_CP010989.1\|WP_010241558.1\|4738336_4738972_-\|RNA-polymerase-sigma-factor-SigE	gnl\|CDD\|236606	PRK09647, PRK09647, RNA polymerase sigma factor SigE; Reviewed.	3.61929e-112
NZ_CP010989.1\|WP_145982697.1\|4750744_4751725_+\|hypothetical-protein	gnl\|CDD\|226974	COG4626, COG4626, Phage terminase-like protein, large subunit [General function prediction only].	8.8454e-18
NZ_CP010989.1\|WP_060573901.1\|4737686_4738340_-\|zf-HC2-domain-containing-protein	gnl\|CDD\|274904	TIGR03988, antisig_RsrA, mycothiol system anti-sigma-R factor. Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors].	1.26882e-05
NZ_CP010989.1\|WP_060573900.1\|4736037_4737594_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	6.09008e-77
NZ_CP010989.1\|WP_060722282.1\|4739233_4739833_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	1.0338e-31
NZ_CP010989.1\|WP_060721796.1\|4739889_4741185_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	2.81815e-60

>NZ_CP010989.1|WP_060573903.1|4741747_4742104_-|hypothetical-protein
MTVFSVESDRVEGLYGTREEAERAAEEYREAERTEHEIPAVSVWGYELNQGPGRLVTVYPRRNAKLMELTLDELLTRDRELQAGPSKERSALVAEMRKRFDKEGWRRFQDQLIAQRED
>NZ_CP010989.1|WP_145982836.1|4741070_4741544_+|tyrosine-type-recombinase/integrase
MARGQRPAPGRARPCRRGVPGRQARRTTRRPHPTQSRLKDLHPQVLTIAPLALRRYLRARQVDSESLFLSQKGPMTVSTLGQALHRRGALAGVKGVHPHRFRHQFAHDWLAAGGSEGDLQRLAGWSSRAMLQRYGSSGAAARAVEAHRSMGLDQKYA
>NZ_CP010989.1|WP_060721796.1|4739889_4741185_+|IS256-family-transposase
MLSVVPSEPDDRDDHTTGAAQESSSLIDQIVRDGARRMLAEALQAEVDAYCARFSHERDEHGRRMVVRNGSHQPREILTSAGAVEVTAPRVNDRRVDPDTGQRRRFSSAILPPWCRKTPKINEVLPLLYLHGLSSGDFGPALGQFLGSSAGLSSSAITKLTETWKAEQRAFAERELSGVDYVYLWADGIHVNVRLEEHKLCLLVMIGVRADGRKELIALTDGYRESTESWADLLRDCARRGMSAPILAVGDGALGFWGALREVFPQAREQRCWFHKIANILGALPKSAHPAAKKALAEVWNAEDRRHALNAAAAFEAAYGAKFPKAVAKLTDDLDELLAFYDYPAEHWIHLRTTNPIESTFATVRNRSKITKGPGSRAAGLAMAFKLIEAAQDRWRAVNAPHLVALVRAGAVFQAGKLVERPDDHTQPKAA
>NZ_CP010989.1|WP_060722282.1|4739233_4739833_+|tyrosine-type-recombinase/integrase
MDASLVDDWKLSLTIANKAPSTITGYLSTARCYVAWCGARSGLTKRDLQGFLAHRIDAGYSPAGTANHYRCLQAWFKWMVEEEIIERSPFDKLKAPFVPEKEVPLLTRDEVSKLLNACKQGRKITGLRDTAVIRLLLDTGLRASELCRLTLDDVDFDLQTIRVYGKGRKFRTVVFGDKPALAEQCLESVDDEEGSYPPG
>NZ_CP010989.1|WP_010241558.1|4738336_4738972_-|RNA-polymerase-sigma-factor-SigE
MPAPRTADDAPVRDAAGTRPGEGADWTPPSWDEVVREHADRVYRLAYRLSGNQHDAEDLTQETFIRVFRSLASYKPGTFEGWLHRITTNLFLDMVRRRARLRMEGLPEDTERLPGGGPEPETVFAINHLDPHLQAALDELPPDFRVAVVLCDVEGLSYEEIGATLGVKLGTVRSRIHRGRTALRASLERHRAAERDEAVATDRNPVAELTS
>NZ_CP010989.1|WP_060573901.1|4737686_4738340_-|zf-HC2-domain-containing-protein
MTDRRRFQVVPPDWGEAHLTLEAVVAYVDDELARGPHDRATRHLGHCPDCAAEVAEQRRARSALRGADAPTLPPSLMSALRSIPQDTELPPPPAGLSLTPDGELVSVLRPAEFGDTGERRSRRSRRVRLGTGAAVSGIALGALAFGVPAATTSAPAPGGPGPGAAAVARFATTPTQAPRQRSSSATPAPGTPASPTGGVAPAAPTSTVRNAGLPPSG
>NZ_CP010989.1|WP_060573900.1|4736037_4737594_-|trypsin-like-peptidase-domain-containing-protein
MSGTPDHGDDRPGDPAGSAPPRLEPRPLTRPDTDPGERAAFGRPDGVGSSFAPPSRHGSRNGSGLPAAPPPTAAVARAFGRPEDEGPGLQRPAADEAEGPATPGEQSKEAFWPGGSTDDPWRDPGTPVVASAPHGDADPEPGPDPEDGPRLSVRDVLFGKRVQPRALALLGVLALGIGALGGLVGHWTASGASELTSPGAVLASAEEAKERPPGSVPEVAGRVLPSVVSLEVSVGNQAGNGSGIVIDPEGYVLTNDHVVAPAAGPGEGSVEAVFSDGSRLPATVVGADPMTDLAVVKVPVANPTVAAIGRSSELAVGDAVIAIGSPFGLAGTVTTGIVSAVDRPVRLDPEGSAGDAVIDAVQTDAAINPGNSGGPLVDATGAVVGINTAIRSASAAEGGGQGGSIGLGFAIPIDDARAIAEELIRSGRVAHADLGVNARSVTDGSTDGAQVQNVVAGGPAAAAGVVEGDVVVRVAGRPIAGADEFVVAVREHDPGEQIPIELVRQGRPLTVTATLGER
>NZ_CP010989.1|WP_060573899.1|4735522_4735987_-|Sec-independent-protein-translocase-subunit-TatB
MFENIGMWEILVLVVAGLFILGPDRLPEAARWLGSAVRQVKDYATGAQNHLKKELGPEFDQIRQPLDDLRSLRSLNPRRAITRSLFSDDDPVKPNGFAPGAAGSNGSAAAAGGVAATGAAGAAGAATSAPAPAPRPPQQPLSSGEQPPVDPDAT
>NZ_CP010989.1|WP_060633589.1|4734078_4735488_+|amidase
MSETTADLSATELLAAYRTGEVSPVQATRDALDRIEAHDGAVNAYCLVDADSALARAKESEARWQAGEPIGPLDGVPTSIKDMLLTIGWPTRRGSTTTSPDGPFEVDGPPVARVRAAGAVLLGKNTTPELAWKGVTDSPLTGVTTNPWDPTRTAGGSSGGSASAVGLGMGPLSLGTDAGGSVRIPAAFTGTVAHKPTYGRIAHYPGSAFGTLAHVGPMTRTVADAALLHDVVAQPDTRDPWVFDVPRESAVDRLAGGAQGLRIAFSPTLGFVDVDPEVAALVADAVAVFSRALGATVEHADPGFADPIEPFHTLWFAAAAKSLEPIGAEARAAMDPALVGIAEQGERVSALDYLGAMAVRNELGTLMGAFHDSYDLLLTPTLPITAFEGGREVPEGWHDPRWTSWTPFTYPFNMTQQPATSVPCGFTSAGLPVGLQVVGPRHADATVLAAAHAYQQATEHHLRRPALLG
>NZ_CP010989.1|WP_050802359.1|4733029_4733980_+|D-2-hydroxyacid-dehydrogenase
MTALCAGDAPPGIDDRIGDARLRIVSSADELAAALPGSDVLLTWDFTSDAVRQVWSPERTADLRWVHTASAGVDRVAFPELLSSPVTLTNSRGVFDRPMAEFVLGAVIAFAKDTARSLALQRERTWQHRETETVAGKVATVVGSGPIGHAIADLLGAVGMTVRLVGRRAADGVHAFDELPGLLPDSDHLVLAAPLTDATRGMLHSGTIALLPERARVINVGRGPLVVQDDLTDALASGRIAGAALDVFEVEPLPADSPLWDMENVLLSPHMSGDVVGWKTMLVDLFADNLARFREGRELRNVVDPERGYVSTGANS
>NZ_CP010989.1|WP_082399135.1|4742619_4743168_+|GIY-YIG-nuclease-family-protein
MNNVCTRIIDDSNPGSPSGNEYGSPRMCGSTEAVQITKDGFLACQDCRIEVTNRQLYKSDKAVLEANTPTSIYILKTPQGSLKIGRAVDLYRRLQELHRDQFGGRLQVLASFVGTHQDEADLHIWFNDFRITGVLGEQFYDVPAIRDHAQSVGIDPAGQLAVSRYSRYTPQNDPKTNKDYVK
>NZ_CP010989.1|WP_145982693.1|4743508_4744066_+|hypothetical-protein
MDRKQFKGKDPFSDEFQEELEKQQAAREAEQQAQVVSRTPAVPNGAVDPIANPRRAKKTSPGPKKQEPADDGGQVPWRKPASQAEHMKAIRSSHSLKGNARLVAFDAHLQIGLESVSNGTEFPDTKKELTAAYLAMFTGLSENKARDWMKEACRLGFFRRVDNGKGGRNNSNRATYLPTVPQWFS
>NZ_CP010989.1|WP_145984032.1|4744349_4744763_-|hypothetical-protein
MVYAKKGFGLQQDEIRELQRDKRADQASQVVSWAEKDTPNFYRVKLVNNSSIPVYLVYFWLTDGTGARRGGTRVGLLPPGTSVERVGPVRWRSTLYSEMAFVDSHNRYWLRSFNGNLDEIEPGEWVGRTGRAFTDED
>NZ_CP010989.1|WP_145982695.1|4744840_4745287_-|hypothetical-protein
MNEFWKAVSKAQDKIEKAAEKVQDQEDGQLLLFQYLEARTGISEAMNELHETVIKRLRDLDPMTHKTLTQAGSPPPLVASEGKYLVEQFDEEGELERKHWVDNRYEAVVLVKAFTDYLEHDGEGLRLMASGENDHLLAEGQRFVVTKL
>NZ_CP010989.1|WP_060573909.1|4745851_4746664_-|ExeA-family-protein
MIDQLSGYFGFSRTPFGRDLAPGMLHRHHAHGEAVARIQWCIGEHALGVITGEVGVGKTVAVRAALAGIDPARHIVIYLGNPDVGTRGIQHAIVTALGGVPRPHRATLIPQALDALATEYAERGRVPVVVLDEAHQLSHEQLEGVRMLTNHDMDSSSPLACLLVGQPTLRRKIKLGMLAALDQRIAVRYHLGGMTGDETVSYLRHHLTLVGRSDTLFSDDAVSLIHTTSRGAPRAVNNLALQSLLAAYAADKTIVDESSARTAVTEVTTE
>NZ_CP010989.1|WP_060721787.1|4746656_4748108_-|DDE-type-integrase/transposase/recombinase
MSQTDNDARRRAERARRVALFRYELIQEVIDPTLTARQRGKLVRELAERAHPGPFAEPVQVTRHTIDRWVRAWRVGGFEALVPQPAKVTARTPPEVLATAAALKRENPGRTAAQITRILRAQSGWAPNERTLQRHFERLELGLIVDEAGHEQRLTAAPAAFGRFEADRPDELWVGDALHGPQIAGHKVYLFAFLDDRSRAVMAARFGFSEDTVRLAAALRPALASRGVPESIYVDNGSAFVDSWLLRGCASLGIKLVHSTPGRPQGRGKIERFFRTVREQFLVEITPDRAAEIADLAELNRLFTAWVETEYHPRTHSETGVAPMARWLDGLASPLPRPTPAQLREAFLWSEHRTVAKTATVSLHGNTYQVDELLVGRKVELVFDPFDLTELVVRYSGREFGTAVAHHIGRHAHPKARPEIPDTTLEPTGIDYLRLIDTTHTERLEGRINYSALLERHHSNTPVEPESVELTIPELQAQETQDD
>NZ_CP010989.1|WP_060576312.1|4748171_4748780_-|hypothetical-protein
MVTVGKNVVEVEARLVAGRLECRCGGRLRPWGHARARVLRGTGALGWRLRPRRARCSGCGTTHVLLPVGVLARRADLVAVIGAALALAATGWGHRRVAERVGRAAGTVRGWLRRWRARAEGLRVEFTALAAALDPLAAMPDPASSGTGDAVAALLAAAAAVTRRWAATVDGLSPWELAGAVTSGRLLAPPSSTESINTRCPW
>NZ_CP010989.1|WP_145982696.1|4748868_4749624_+|hypothetical-protein
MITLSSHTNAIGPRTRPHRVVTANDGPRSTRGHEERRRTNDPRNRNHRRVWQYLVDEFGKSRSVDTAYQIYKADYPDKAMSRLTFKRYAETPPAGTKNWIWKMNEPYNDLDVQAHTNWLRDSDDSPSAWAQAVPGCLEVLTPAERRAVDAFYEGENVFSSSHPSRKSFSRAKAKLAVELDGYETLTEPEVEVPADLLELVGIKTRRSTVKLRHSIEGSGRSFPVQAIVSDSSPDGDSLNKTGRIAKGLPRA
>NZ_CP010989.1|WP_145982697.1|4750744_4751725_+|hypothetical-protein
MALKPLPGATLIGSTTPRLFTEPLQELTPETSLGFEAIRFANVILGIELLPWQEWWLIHALELHDGRLRYKTVVTLLPRQNGKTELLSIFSLYLMFSDRAKLILGTAQALDIAREAWTKSVDHAQASPHTAPEIKDVRRTNGEQCITLRSGARYRISATTRGAGRGLSVDLLILDELREHRDWDSWSALAATTTARPESLKVGISNAGDSSSVVLNTLRASALTGDETTLGLFEWSAPDGCELDDPDAWVSSNPSLGYLITEDTLRGALATSTPAVFRTEHLCQTVESSNAWNLWMTRRGRTLPDDLQGLKQDRRANAGREGTTHA
>NZ_CP010989.1|WP_060721796.1|4751717_4753013_+|IS256-family-transposase
MLSVVPSEPDDRDDHTTGAAQESSSLIDQIVRDGARRMLAEALQAEVDAYCARFSHERDEHGRRMVVRNGSHQPREILTSAGAVEVTAPRVNDRRVDPDTGQRRRFSSAILPPWCRKTPKINEVLPLLYLHGLSSGDFGPALGQFLGSSAGLSSSAITKLTETWKAEQRAFAERELSGVDYVYLWADGIHVNVRLEEHKLCLLVMIGVRADGRKELIALTDGYRESTESWADLLRDCARRGMSAPILAVGDGALGFWGALREVFPQAREQRCWFHKIANILGALPKSAHPAAKKALAEVWNAEDRRHALNAAAAFEAAYGAKFPKAVAKLTDDLDELLAFYDYPAEHWIHLRTTNPIESTFATVRNRSKITKGPGSRAAGLAMAFKLIEAAQDRWRAVNAPHLVALVRAGAVFQAGKLVERPDDHTQPKAA

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP010989_2	2.1\|745453\|35\|NZ_CP010989\|CRISPRCasFinder	745453-745487	35	NZ_CP010989.1	745514-745548	1	0.971

1. spacer 2.1|745453|35|NZ_CP010989|CRISPRCasFinder matches to position: 745514-745548, mismatch: 1, identity: 0.971

gccgcaccccgtggcgggcgtcacgcaccccgtcg	CRISPR spacer
gccgcaccccgtggtgggcgtcacgcaccccgtcg	Protospacer
**************.********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

75 : 52937

Mycobacterium_phage(50.0%)

transposase,integrase

attL 43943:43959|attR 56012:56028

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_082399267.1\|75_867_+\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
WP_060577643.1\|992_2972_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_060577624.1\|2962_4042_+	ATP-binding protein	NA	NA	NA	NA
WP_060577623.1\|4038_4839_+	hypothetical protein	NA	NA	NA	NA
WP_060577642.1\|5219_6356_+	AAA family ATPase	NA	NA	NA	NA
WP_060577622.1\|6410_6656_+	hypothetical protein	NA	NA	NA	NA
WP_060577621.1\|6873_7296_-	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_145986130.1\|7485_8013_-	TIGR03086 family protein	NA	NA	NA	NA
WP_174521802.1\|8737_9553_+	phytanoyl-CoA dioxygenase	NA	NA	NA	NA
WP_060722397.1\|9632_10481_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_060721784.1\|10708_11350_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_060721785.1\|11389_11692_-	hypothetical protein	NA	NA	NA	NA
WP_168170443.1\|11725_12325_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_145982511.1\|12594_13539_+	WYL domain-containing protein	NA	NA	NA	NA
WP_060573909.1\|13702_14515_-	ExeA family protein	NA	NA	NA	NA
WP_060721787.1\|14507_15959_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_060576312.1\|16022_16631_-	hypothetical protein	NA	NA	NA	NA
WP_060721788.1\|17005_18304_-	cation:proton antiporter	NA	NA	NA	NA
WP_060721789.1\|20248_20527_+	FCD domain-containing protein	NA	NA	NA	NA
WP_060721790.1\|20616_21108_+	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_060721791.1\|21166_22390_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_145982512.1\|22927_23176_+	ribbon-helix-helix domain-containing protein	NA	NA	NA	NA
WP_060721793.1\|27677_28910_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_145982513.1\|29020_30285_-\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	4.2e-94	56.5
WP_082398747.1\|30402_30837_+	hypothetical protein	NA	NA	NA	NA
WP_060721796.1\|30893_32189_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.8e-178	72.7
WP_145982514.1\|32209_32557_+	hypothetical protein	NA	NA	NA	NA
WP_145982515.1\|32932_33259_-\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	3.5e-21	58.3
WP_060721798.1\|33422_33815_-	hypothetical protein	NA	NA	NA	NA
WP_082398748.1\|33811_34021_-	hypothetical protein	NA	NA	NA	NA
WP_168170444.1\|34407_36711_-	HAD-IC family P-type ATPase	M1HLC0	Paramecium_bursaria_Chlorella_virus	1.2e-33	25.9
WP_145982777.1\|37008_37422_-	DoxX family protein	NA	NA	NA	NA
WP_010229591.1\|37672_38368_-	dienelactone hydrolase family protein	NA	NA	NA	NA
WP_060577504.1\|39441_40224_-	hypothetical protein	NA	NA	NA	NA
WP_060577503.1\|42266_42920_-	GPP34 family phosphoprotein	NA	NA	NA	NA
WP_060577502.1\|43070_44729_+	APC family permease	NA	NA	NA	NA
43943:43959	attL	NA	NA	NA	NA
WP_060721800.1\|44948_45305_-	hypothetical protein	NA	NA	NA	NA
WP_060577500.1\|45599_45809_+	hypothetical protein	NA	NA	NA	NA
WP_082398750.1\|45910_47494_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_060577625.1\|47642_48206_+	TIGR03086 family protein	NA	NA	NA	NA
WP_060721801.1\|50075_50594_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_060573909.1\|50680_51493_-	ExeA family protein	NA	NA	NA	NA
WP_060721787.1\|51485_52937_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
56012:56028	attR	NA	NA	NA	NA

DBSCAN-SWA_2

963480 : 1015022

Rhodococcus_phage(10.0%)

transposase,protease,integrase

attL 974337:974353|attR 1013064:1013080

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_082399315.1\|963480_964494_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_060721881.1\|965570_966719_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_082399317.1\|966755_966974_+	transglycosylase family protein	A0A1I9SA30	Rhodococcus_phage	4.6e-09	54.4
WP_060575097.1\|967113_968661_+	serine/threonine protein kinase	M1PCM5	Moumouvirus	3.0e-17	28.3
WP_060575098.1\|968647_970528_-	S9 family peptidase	NA	NA	NA	NA
WP_060575099.1\|970610_973187_-	carboxylate--amine ligase/circularly permuted type 2 ATP-grasp protein	NA	NA	NA	NA
974337:974353	attL	NA	NA	NA	NA
WP_082398825.1\|975065_975872_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_060721882.1\|975889_976564_-	DUF429 domain-containing protein	NA	NA	NA	NA
WP_010225435.1\|976582_977050_+	ribose-5-phosphate isomerase	A0A222YX14	Synechococcus_phage	1.7e-08	28.7
WP_060575100.1\|977049_977865_+	Fpg/Nei family DNA glycosylase	A0A1V0CNR6	Kaumoebavirus	1.8e-05	26.1
WP_010225439.1\|977876_978656_+	HAD family hydrolase	NA	NA	NA	NA
WP_060575101.1\|978702_980163_-	acetyl-CoA carboxyl transferase	NA	NA	NA	NA
WP_060575102.1\|980159_981347_-	CoA transferase	NA	NA	NA	NA
WP_060575103.1\|981376_982741_-	SLC13 family permease	NA	NA	NA	NA
WP_060722408.1\|982931_983615_+	FadR family transcriptional regulator	NA	NA	NA	NA
WP_139323942.1\|983630_984293_-	RraA family protein	NA	NA	NA	NA
WP_082398827.1\|984303_985767_-	AMP-binding protein	Q75ZG1	Hepacivirus	1.3e-27	32.6
WP_050802427.1\|985763_987080_-	MHS family MFS transporter	Q6JIH2	Burkholderia_virus	1.2e-32	30.6
WP_060575105.1\|987232_988111_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_060575106.1\|988118_988874_+	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	3.3e-06	27.4
WP_010228145.1\|989213_989504_+	hypothetical protein	NA	NA	NA	NA
WP_010228144.1\|989585_991034_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_010228143.1\|991228_992092_+	universal stress protein	NA	NA	NA	NA
WP_010228142.1\|992088_992616_-	DsbA family protein	NA	NA	NA	NA
WP_010228141.1\|992666_994007_+	Na+/H+ antiporter NhaA	A0A2H4J5W3	uncultured_Caudovirales_phage	5.1e-58	39.8
WP_060575107.1\|994008_995085_-	AlkZ family DNA glycosylase	NA	NA	NA	NA
WP_060575108.1\|995081_995408_-	DUF4180 domain-containing protein	NA	NA	NA	NA
WP_145982543.1\|995507_995963_+	hypothetical protein	NA	NA	NA	NA
WP_060575110.1\|996051_997095_+	NAD(P)-dependent alcohol dehydrogenase	K7Z7U2	Megavirus	6.9e-10	24.5
WP_060575111.1\|997142_997751_+	hypothetical protein	NA	NA	NA	NA
WP_060575112.1\|997778_998729_-	phosphotransferase	NA	NA	NA	NA
WP_060575113.1\|998800_999157_+	VOC family protein	NA	NA	NA	NA
WP_060575114.1\|999191_999866_-	class F sortase	NA	NA	NA	NA
WP_033199283.1\|999935_1000739_-	hypothetical protein	NA	NA	NA	NA
WP_060576498.1\|1001130_1002051_+	ferritin-like domain-containing protein	NA	NA	NA	NA
WP_060721883.1\|1002140_1002839_-	ANTAR domain-containing protein	NA	NA	NA	NA
WP_060575116.1\|1002923_1003529_-	response regulator transcription factor	NA	NA	NA	NA
WP_168170454.1\|1003525_1004755_-	two-component sensor histidine kinase	NA	NA	NA	NA
WP_145982545.1\|1004763_1005681_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_060721884.1\|1005990_1006377_-	hypothetical protein	NA	NA	NA	NA
WP_060575119.1\|1006521_1007451_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_060576499.1\|1007623_1008100_+	NUDIX domain-containing protein	NA	NA	NA	NA
WP_168170455.1\|1008367_1008649_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_168170456.1\|1010013_1010187_-	hypothetical protein	NA	NA	NA	NA
WP_145982547.1\|1010308_1010530_+	hypothetical protein	NA	NA	NA	NA
WP_060575120.1\|1010587_1010806_-	cold shock domain-containing protein	NA	NA	NA	NA
WP_060575121.1\|1011049_1011967_+\|integrase	tyrosine-type recombinase/integrase	A0A142F1N9	Bacillus_phage	2.6e-13	25.1
WP_060575122.1\|1012233_1012431_-	hypothetical protein	NA	NA	NA	NA
WP_082399092.1\|1013924_1015022_+\|transposase	IS110 family transposase	NA	NA	NA	NA
1013064:1013080	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1172340 : 1235438

Agrobacterium_phage(25.0%)

transposase,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060572134.1\|1172340_1173564_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_082398847.1\|1173868_1174534_-	RNA polymerase sigma factor	NA	NA	NA	NA
WP_010232510.1\|1174696_1174879_+	CsbD family protein	NA	NA	NA	NA
WP_010232509.1\|1174971_1175277_+	hypothetical protein	NA	NA	NA	NA
WP_060575214.1\|1175495_1176947_+	trigger factor	NA	NA	NA	NA
WP_029239652.1\|1177244_1177841_+\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	4.9e-37	44.4
WP_010232505.1\|1177840_1178533_+\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	8.8e-38	43.3
WP_010232504.1\|1178737_1180027_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	4.6e-141	60.9
WP_060575215.1\|1180162_1181566_+	OFA family MFS transporter	NA	NA	NA	NA
WP_010232502.1\|1181562_1181706_+	hypothetical protein	NA	NA	NA	NA
WP_060575216.1\|1181786_1183331_+	alkaline phosphatase D family protein	NA	NA	NA	NA
WP_082399331.1\|1183352_1184612_-	family 43 glycosylhydrolase	NA	NA	NA	NA
WP_145982562.1\|1184608_1186087_-	MFS transporter	NA	NA	NA	NA
WP_060721899.1\|1186186_1186609_-	PPOX class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_060575218.1\|1186673_1187888_+	MFS transporter	NA	NA	NA	NA
WP_145982563.1\|1187920_1188436_+	hypothetical protein	NA	NA	NA	NA
WP_060721900.1\|1188576_1191213_+\|tRNA	valine--tRNA ligase	A0A1V0SK04	Klosneuvirus	4.1e-144	39.4
WP_082398849.1\|1191218_1192886_+	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_050802419.1\|1192945_1193302_+	DUF4233 domain-containing protein	NA	NA	NA	NA
WP_082399335.1\|1193345_1193546_+	ribbon-helix-helix protein, CopG family	NA	NA	NA	NA
WP_060575221.1\|1193553_1193943_+	Fic family protein	NA	NA	NA	NA
WP_060576517.1\|1193990_1194401_+	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	2.1e-26	47.7
WP_060575222.1\|1194397_1194919_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_060575223.1\|1194987_1195764_+	hypothetical protein	NA	NA	NA	NA
WP_010232594.1\|1195843_1196722_+	4-hydroxy-tetrahydrodipicolinate synthase	NA	NA	NA	NA
WP_060721901.1\|1196736_1197348_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_060575225.1\|1197431_1199030_+	AMP-binding protein	NA	NA	NA	NA
WP_060576518.1\|1199077_1202221_+	carbamoyl-phosphate synthase large subunit	NA	NA	NA	NA
WP_060575226.1\|1202320_1203367_+	glycerophosphodiester phosphodiesterase	NA	NA	NA	NA
WP_060575227.1\|1204326_1205238_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_010231659.1\|1205326_1206385_+	ferredoxin reductase	NA	NA	NA	NA
WP_029239612.1\|1206593_1207658_+	acyl-CoA desaturase	NA	NA	NA	NA
WP_010231665.1\|1207720_1208146_+	hypothetical protein	NA	NA	NA	NA
WP_010231668.1\|1208156_1208537_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_010231670.1\|1208730_1209480_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_060575229.1\|1209488_1210700_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_082398850.1\|1210696_1212079_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_060575230.1\|1212395_1214396_+	TIGR03960 family B12-binding radical SAM protein	NA	NA	NA	NA
WP_139317096.1\|1214535_1214937_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_060575231.1\|1214879_1215701_-	hypothetical protein	NA	NA	NA	NA
WP_060575232.1\|1215789_1216605_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_060575005.1\|1216707_1217799_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_174521760.1\|1217856_1218663_+	DUF2344 domain-containing protein	NA	NA	NA	NA
WP_060575233.1\|1218836_1222235_+	translation initiation factor IF-2 N-terminal domain-containing protein	NA	NA	NA	NA
WP_010235601.1\|1222398_1222704_+	50S ribosomal protein L21	NA	NA	NA	NA
WP_010235598.1\|1222716_1222974_+	50S ribosomal protein L27	NA	NA	NA	NA
WP_060575234.1\|1223072_1224572_+	GTPase ObgE	NA	NA	NA	NA
WP_010240124.1\|1224568_1225681_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.1e-53	39.4
WP_060575235.1\|1225732_1226956_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	NA	NA	NA	NA
WP_033200394.1\|1226977_1227379_-	nitroreductase family deazaflavin-dependent oxidoreductase	NA	NA	NA	NA
WP_060721902.1\|1227448_1228495_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_050802511.1\|1228553_1230683_-	RecQ family ATP-dependent DNA helicase	Q9DSV4	Diadromus_pulchellus_ascovirus	3.7e-42	33.3
WP_010240136.1\|1230639_1231539_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_082398851.1\|1231627_1232614_+	ATP-binding cassette domain-containing protein	W5SAS9	Pithovirus	2.1e-16	30.0
WP_060575236.1\|1232610_1233417_+	ABC transporter permease	NA	NA	NA	NA
WP_060575237.1\|1233496_1234381_+	MoxR family ATPase	NA	NA	NA	NA
WP_145982793.1\|1234715_1235438_+\|protease	serine protease	NA	NA	NA	NA

DBSCAN-SWA_4

4739233 : 4754196

Mycobacterium_phage(66.67%)

transposase,capsid,integrase

attL 4739779:4739838|attR 4751607:4753046

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060722282.1\|4739233_4739833_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
4739779:4739838	attL	NA	NA	NA	NA
WP_060721796.1\|4739889_4741185_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.8e-178	72.7
WP_145982836.1\|4741070_4741544_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_060573903.1\|4741747_4742104_-	hypothetical protein	NA	NA	NA	NA
WP_082399135.1\|4742619_4743168_+	GIY-YIG nuclease family protein	NA	NA	NA	NA
WP_145982693.1\|4743508_4744066_+	hypothetical protein	NA	NA	NA	NA
WP_145984032.1\|4744349_4744763_-	hypothetical protein	NA	NA	NA	NA
WP_145982695.1\|4744840_4745287_-	hypothetical protein	NA	NA	NA	NA
WP_060573909.1\|4745851_4746664_-	ExeA family protein	NA	NA	NA	NA
WP_060721787.1\|4746656_4748108_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_060576312.1\|4748171_4748780_-	hypothetical protein	NA	NA	NA	NA
WP_145982696.1\|4748868_4749624_+	hypothetical protein	NA	NA	NA	NA
WP_145982697.1\|4750744_4751725_+	hypothetical protein	A0A222ZEP5	Arthrobacter_phage	4.1e-73	47.7
WP_060721796.1\|4751717_4753013_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.8e-178	72.7
WP_082399136.1\|4752939_4754196_+\|capsid	phage major capsid protein	NA	NA	NA	NA
4751607:4753046	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP010990

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

6741 : 51841

Mycobacterium_phage(60.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060573872.1\|6741_7992_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_060722477.1\|8250_8757_+	hypothetical protein	NA	NA	NA	NA
WP_082399757.1\|9018_9831_-	hypothetical protein	NA	NA	NA	NA
WP_060721796.1\|9917_11213_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.8e-178	72.7
WP_060722479.1\|11647_11914_-	hypothetical protein	NA	NA	NA	NA
WP_168170572.1\|11990_12143_-	hypothetical protein	NA	NA	NA	NA
WP_060722480.1\|12713_13673_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	4.1e-09	31.0
WP_082399759.1\|13771_14218_-	hypothetical protein	NA	NA	NA	NA
WP_082399661.1\|14392_14695_-	hypothetical protein	NA	NA	NA	NA
WP_060722483.1\|15053_15323_-	hypothetical protein	NA	NA	NA	NA
WP_060722484.1\|15465_16158_-	hypothetical protein	NA	NA	NA	NA
WP_082399761.1\|16207_16729_-	hypothetical protein	NA	NA	NA	NA
WP_060722486.1\|17231_17495_-	hypothetical protein	NA	NA	NA	NA
WP_174521823.1\|17650_17800_-	hypothetical protein	NA	NA	NA	NA
WP_082399092.1\|17948_19046_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_082399664.1\|19218_20250_-	bifunctional DNA primase/polymerase	Q854C1	Mycobacterium_phage	5.7e-09	31.8
WP_060722487.1\|20576_21056_-	hypothetical protein	NA	NA	NA	NA
WP_060722488.1\|21115_21637_-	hypothetical protein	NA	NA	NA	NA
WP_082399666.1\|21717_22125_-	WhiB family transcriptional regulator	A0A142K674	Streptomyces_phage	3.0e-09	51.5
WP_060722489.1\|22218_22626_-	single-stranded DNA-binding protein	A0A1J0MC80	Streptomyces_phage	1.7e-12	39.3
WP_060722490.1\|22957_23461_-	hypothetical protein	NA	NA	NA	NA
WP_145982852.1\|23595_24860_-\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	1.4e-94	56.8
WP_060722494.1\|27065_27569_-	DUF3145 family protein	NA	NA	NA	NA
WP_060722495.1\|27572_27803_-	hypothetical protein	NA	NA	NA	NA
WP_060722496.1\|27930_28245_-	hypothetical protein	NA	NA	NA	NA
WP_145982878.1\|28346_29447_-	DUF932 domain-containing protein	A0A140G6P2	Arthrobacter_phage	3.8e-83	44.9
WP_060577586.1\|29945_30224_+	hypothetical protein	NA	NA	NA	NA
WP_082399765.1\|30223_30526_+	hypothetical protein	NA	NA	NA	NA
WP_060722577.1\|30601_31621_-	hypothetical protein	NA	NA	NA	NA
WP_060722498.1\|32133_32427_-	hypothetical protein	NA	NA	NA	NA
WP_060577583.1\|32755_33736_-	bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase	NA	NA	NA	NA
WP_060577582.1\|33732_34257_-	hypothetical protein	NA	NA	NA	NA
WP_168170573.1\|35484_36363_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_060577579.1\|36368_36938_-	hypothetical protein	NA	NA	NA	NA
WP_060577578.1\|36934_37342_-	hypothetical protein	NA	NA	NA	NA
WP_082399676.1\|38054_39017_+	hypothetical protein	NA	NA	NA	NA
WP_145982854.1\|39013_39667_+	hypothetical protein	NA	NA	NA	NA
WP_145982513.1\|39696_40961_-\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	4.2e-94	56.5
WP_060722502.1\|41528_42602_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_145982855.1\|43084_43309_-	hypothetical protein	NA	NA	NA	NA
WP_174521824.1\|43777_45289_-	recombinase XerD	NA	NA	NA	NA
WP_060575992.1\|45303_45636_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_060721796.1\|45831_47127_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.8e-178	72.7
WP_060722505.1\|48616_49453_+	NAD(P)H-binding protein	NA	NA	NA	NA
WP_060722506.1\|49842_50553_+	hypothetical protein	NA	NA	NA	NA
WP_060721796.1\|50545_51841_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.8e-178	72.7

DBSCAN-SWA_2

88623 : 151908

Mycobacterium_phage(30.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060721796.1\|88623_89919_-\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.8e-178	72.7
WP_060721796.1\|91892_93188_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.8e-178	72.7
WP_082399681.1\|93114_93945_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_060722515.1\|94556_95876_-	MHS family MFS transporter	Q6JIH2	Burkholderia_virus	1.1e-33	28.1
WP_082399683.1\|96972_97077_-	rubredoxin	NA	NA	NA	NA
WP_060722517.1\|97656_97950_+\|transposase	transposase	Q9ETV7	Enterobacteria_phage	5.4e-05	33.7
WP_168170571.1\|98452_98692_+	hypothetical protein	NA	NA	NA	NA
WP_145982513.1\|98713_99977_+\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	4.2e-94	56.5
WP_060575005.1\|100316_101408_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_060575006.1\|101930_102350_-	PIN domain nuclease	NA	NA	NA	NA
WP_060576479.1\|102340_102565_-	hypothetical protein	NA	NA	NA	NA
WP_145982879.1\|103075_104285_+\|transposase	IS3 family transposase	A0A160DCU2	Gordonia_phage	6.0e-74	48.1
WP_060722519.1\|104447_104810_+	hypothetical protein	NA	NA	NA	NA
WP_082399689.1\|104849_105206_+	maleylpyruvate isomerase N-terminal domain-containing protein	NA	NA	NA	NA
WP_060575005.1\|105721_106813_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_082399691.1\|110192_110987_+	FadR family transcriptional regulator	NA	NA	NA	NA
WP_060577556.1\|112747_115423_+	DUF2156 domain-containing protein	NA	NA	NA	NA
WP_060722522.1\|115896_116406_-\|transposase	transposase	NA	NA	NA	NA
WP_145982858.1\|116490_117315_-\|transposase	IS3 family transposase	Q6H9S6	Enterobacteria_phage	9.5e-31	38.3
WP_060577558.1\|117311_117623_-\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	5.5e-16	50.9
WP_060575005.1\|117742_118834_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_060721796.1\|119855_121151_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.8e-178	72.7
WP_082399697.1\|121178_122102_+	DegT/DnrJ/EryC1/StrS family aminotransferase	A0A2D2W2B8	Stenotrophomonas_phage	5.3e-06	38.1
WP_060722525.1\|122491_123571_+	inositol-3-phosphate synthase	A0A0H4IPK5	Stenotrophomonas_phage	1.9e-71	44.1
WP_082399699.1\|123986_124301_+	hypothetical protein	NA	NA	NA	NA
WP_060722526.1\|124423_125362_-	glucose-1-phosphate thymidylyltransferase RfbA	K7QKA7	Escherichia_phage	8.4e-92	57.4
WP_168170574.1\|125491_125884_-	hypothetical protein	NA	NA	NA	NA
WP_060722580.1\|126070_126589_-	isochorismatase family protein	NA	NA	NA	NA
WP_145982859.1\|127069_128377_+\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	1.2e-11	30.3
WP_145982860.1\|128984_130248_+\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	1.4e-94	56.8
WP_145982861.1\|130858_132114_-\|transposase	IS3 family transposase	A0A160DCU2	Gordonia_phage	1.9e-62	43.8
WP_168170575.1\|132334_133474_-	HAMP domain-containing protein	W8CYF6	Bacillus_phage	3.6e-12	21.0
WP_060577533.1\|133557_134220_-	response regulator transcription factor	W8CYM9	Bacillus_phage	3.4e-23	31.4
WP_060577532.1\|134432_135566_-	hypothetical protein	NA	NA	NA	NA
WP_145982862.1\|135756_135969_+	hypothetical protein	NA	NA	NA	NA
WP_168170576.1\|136055_136232_+	hypothetical protein	NA	NA	NA	NA
WP_060722582.1\|136347_137037_-	aminopeptidase P family protein	NA	NA	NA	NA
WP_060722529.1\|137206_138376_+	NAD-dependent formate dehydrogenase	A0A1B1IVB5	uncultured_Mediterranean_phage	2.8e-20	26.9
WP_060577127.1\|138372_138816_+	cyanase	NA	NA	NA	NA
WP_145982880.1\|138800_139892_-	ATP-binding cassette domain-containing protein	NA	NA	NA	NA
WP_168170577.1\|141623_141791_-	hypothetical protein	NA	NA	NA	NA
WP_168170578.1\|142047_142773_+	class E sortase	NA	NA	NA	NA
WP_145982865.1\|142938_143328_+	hypothetical protein	NA	NA	NA	NA
WP_168170579.1\|143381_143543_+	hypothetical protein	NA	NA	NA	NA
WP_168170580.1\|143840_144230_+	hypothetical protein	NA	NA	NA	NA
WP_145982866.1\|144420_144999_+	hypothetical protein	NA	NA	NA	NA
WP_060577524.1\|145024_145462_-	hypothetical protein	NA	NA	NA	NA
WP_145982867.1\|145458_146301_-	hypothetical protein	NA	NA	NA	NA
WP_145982868.1\|146820_147045_+	hypothetical protein	NA	NA	NA	NA
WP_168170581.1\|147131_148103_+	DNA ligase	A0A068CDF3	Rhizobium_phage	7.3e-22	32.2
WP_082399709.1\|148188_149091_-	hypothetical protein	NA	NA	NA	NA
WP_082399711.1\|149112_150654_-	TraM recognition domain-containing protein	NA	NA	NA	NA
WP_145982860.1\|150644_151908_+\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	1.4e-94	56.8

DBSCAN-SWA_3

160165 : 214261

Mycobacterium_phage(50.0%)

integrase,transposase

attL 170338:170356|attR 214521:214539

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060577510.1\|160165_160912_+\|transposase	IS66 family transposase zinc-finger binding domain-containing protein	NA	NA	NA	NA
WP_082399717.1\|160884_161073_+\|transposase	transposase	NA	NA	NA	NA
WP_168170583.1\|161069_161207_-	hypothetical protein	NA	NA	NA	NA
WP_145982852.1\|161280_162545_-\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	1.4e-94	56.8
WP_168170589.1\|163974_164382_+\|transposase	transposase	NA	NA	NA	NA
WP_145982881.1\|164744_165128_+\|transposase	transposase	NA	NA	NA	NA
WP_060722537.1\|167508_167817_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_060722538.1\|167813_168188_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_060575005.1\|168270_169362_-\|transposase	IS630 family transposase	NA	NA	NA	NA
170338:170356	attL	NA	NA	NA	NA
WP_060577632.1\|171143_171458_+	multidrug efflux SMR transporter	NA	NA	NA	NA
WP_060577633.1\|171457_171835_+	multidrug efflux SMR transporter	NA	NA	NA	NA
WP_082399771.1\|174622_176008_-	DUF839 domain-containing protein	NA	NA	NA	NA
WP_082399725.1\|178667_179009_-	transcriptional regulator	NA	NA	NA	NA
WP_060576312.1\|179097_179706_+	hypothetical protein	NA	NA	NA	NA
WP_060721787.1\|179769_181221_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A2H4JEQ4	uncultured_Caudovirales_phage	5.4e-05	24.7
WP_060573909.1\|181213_182026_+	ExeA family protein	NA	NA	NA	NA
WP_145982869.1\|182205_182496_+	hypothetical protein	NA	NA	NA	NA
WP_082399773.1\|183229_184252_+	acetylxylan esterase	NA	NA	NA	NA
WP_060577564.1\|184768_186241_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_060577565.1\|186440_187487_-	aldo/keto reductase	NA	NA	NA	NA
WP_060577566.1\|187554_188577_-	methyltransferase	NA	NA	NA	NA
WP_060572134.1\|189259_190483_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_060577567.1\|190488_191892_-	hypothetical protein	NA	NA	NA	NA
WP_060722583.1\|191980_193129_-	3-deoxy-7-phosphoheptulonate synthase	NA	NA	NA	NA
WP_082399726.1\|194334_195381_-	hypothetical protein	NA	NA	NA	NA
WP_060577635.1\|195597_196035_-	3-dehydroquinate dehydratase	NA	NA	NA	NA
WP_082399728.1\|197636_198509_+	hypothetical protein	NA	NA	NA	NA
WP_082399775.1\|198686_200264_+	FAD-dependent oxidoreductase	S4VXI2	Pandoravirus	2.0e-24	25.7
WP_082399777.1\|200351_201971_+	oligo-1,6-glucosidase	NA	NA	NA	NA
WP_168170584.1\|202189_202777_+	hypothetical protein	NA	NA	NA	NA
WP_060577571.1\|203090_203996_-	ROK family protein	NA	NA	NA	NA
WP_145982870.1\|204352_204784_-	hypothetical protein	NA	NA	NA	NA
WP_060577572.1\|206430_207483_-	hypothetical protein	NA	NA	NA	NA
WP_060577573.1\|207479_208673_-	hypothetical protein	NA	NA	NA	NA
WP_168170585.1\|209100_209451_+	VOC family protein	NA	NA	NA	NA
WP_060577574.1\|210027_210627_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_145982882.1\|210718_211303_-\|transposase	transposase	NA	NA	NA	NA
WP_174521825.1\|212223_212928_-	hypothetical protein	NA	NA	NA	NA
WP_145982513.1\|212997_214261_+\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	4.2e-94	56.5
214521:214539	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP010991

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP010989

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP010990

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection