CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP012712	Parageobacillus thermoglucosidasius strain DSM 2542 chromosome, complete genome	11 crisprs	cas3,cas8b1,cas7b,cas5,cas4,cas1,cas2,cas6,csa3,WYL,DEDDh,csm6,csx1,cmr1gr7,cas10,cmr3gr5,cmr4gr7,cmr5gr11,DinG	0	12	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012712_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012712_1

9938-11228

Orphan

Consensus_repeat	Method
GTTTGTATCTTACCTATAAGGAATTGAAAC	PILER-CR
GTTTGTATCTTACCTATAAGGAATTGAAAC	CRISPRCasFinder
GTTTGTATCTTACCTATAAGGAATTGAAAC	CRT

19 spacers

The CRISPR arrays of NZ_CP012712_1

>merge|NZ_CP012712|1|9938-11228|PILER-CR,CRISPRCasFinder,CRT
GTTTGTATCTTACCTATAAGGAATTGAAACCTTCATCCAGCGTCAAGTCGTTCATTTCACTTGTCGTTTGTATCTTACCTATAAGGAATTGAAACTTGGGTGGCGCTGTCGCGCACTCCCTTGACCCTCAAGTTTGTATCTTACCTATAAGGAATTGAAACTTTCACATTCCGGCGCTTTTGTTTCAAGAACAGCCTCGTTTGTATCTTACCTATAAGGAATTGAAACTCGACGGCCCCTGAATTAGATCAGCTTGGTGGTATCTCGTTTGTATCTTACCTATAAGGAATTGAAACCTTCAAATGGGATGACTCTAACTATATCAGGATTTCAGTTTGTATCTTACCTATAAGGAATTGAAACATTGAAATGATATGCGACTGGAAAGCTGCGGTGATGTTTGTATCTTACCTATAAGGAATTGAAACCGCTTTCAAACGCCATTAAATCGTCACCTCCTCGGTGTTTGTATCTTACCTATAAGGAATTGAAACTCTGGAACACAAATGAAAGGAGTAATAACTGGATGAAGTTTGTATCTTACCTATAAGGAATTGAAACTCCGTCGAAGAAATGATTTCTTTGCTATTCCGGCTCTCGTTTGTATCTTACCTATAAGGAATTGAAACAGAATATCCATTGAGTAATTGCACTCGACCATGATGTTTGTATCTTACCTATAAGGAATTGAAACCACTATTTTTTGTTATTTCGAGTTGAGCAGCTGTTGTGTTTGTATCTTACCTATAAGGAATTGAAACATGAAAGCACCTTCTTTAGAACGCGACGCTCTCATCGTTTGTATCTTACCTATAAGGAATTGAAACGAAGTAATTAGTCAAGCAATTAGGTGGCAAGGCATGTGTTTGTATCTTACCTATAAGGAATTGAAACTCACGTTTCGAGATATGAGAAAAGAACACGGTCATTTGTTTGTATCTTACCTATAAGGAATTGAAACTGAAGCACCTTGGCGTGAAGAGAAAGTTAAAAAAGGTTTGTATCTTACCTATAAGGAATTGAAACTGACTTCTGCCAAAATCGCTCTATCCTCATTGGCTTGTTTGTATCTTACCTATAAGGAATTGAAACCAGGCGCAGCGAACGCCTTATAGGCACAGCGAACGCCGTTTGTATCTTACCTATAAGGAATTGAAACTCAAGCCGGCCGATTCGCATTCTTTTGGCGGACGAGGTTTGTATCTTACCTATAAGGAATTGAAACTAAACTCAGTAATGTCTGGCTGCCAATCTGCAAGCAGTTTGCATCTTACCTATAAGGATTAAAACC

>NZ_CP012712|1|1|9938-11162|PILER-CR
GTTTGTATCTTACCTATAAGGAATTGAAAC	CTTCATCCAGCGTCAAGTCGTTCATTTCACTTGTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTGGGTGGCGCTGTCGCGCACTCCCTTGACCCTCAA
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTTCACATTCCGGCGCTTTTGTTTCAAGAACAGCCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCGACGGCCCCTGAATTAGATCAGCTTGGTGGTATCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	CTTCAAATGGGATGACTCTAACTATATCAGGATTTCA
GTTTGTATCTTACCTATAAGGAATTGAAAC	ATTGAAATGATATGCGACTGGAAAGCTGCGGTGAT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CGCTTTCAAACGCCATTAAATCGTCACCTCCTCGGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCTGGAACACAAATGAAAGGAGTAATAACTGGATGAA
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCCGTCGAAGAAATGATTTCTTTGCTATTCCGGCTCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	AGAATATCCATTGAGTAATTGCACTCGACCATGAT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CACTATTTTTTGTTATTTCGAGTTGAGCAGCTGTTGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	ATGAAAGCACCTTCTTTAGAACGCGACGCTCTCATC
GTTTGTATCTTACCTATAAGGAATTGAAAC	GAAGTAATTAGTCAAGCAATTAGGTGGCAAGGCATGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCACGTTTCGAGATATGAGAAAAGAACACGGTCATTT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TGAAGCACCTTGGCGTGAAGAGAAAGTTAAAAAAG
GTTTGTATCTTACCTATAAGGAATTGAAAC	TGACTTCTGCCAAAATCGCTCTATCCTCATTGGCTT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CAGGCGCAGCGAACGCCTTATAGGCACAGCGAACGCC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCAAGCCGGCCGATTCGCATTCTTTTGGCGGACGAG
GTTTGTATCTTACCTATAAGGAATTGAAAC

>NZ_CP012712|1|1|9938-11228|CRISPRCasFinder
GTTTGTATCTTACCTATAAGGAATTGAAAC	CTTCATCCAGCGTCAAGTCGTTCATTTCACTTGTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTGGGTGGCGCTGTCGCGCACTCCCTTGACCCTCAA
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTTCACATTCCGGCGCTTTTGTTTCAAGAACAGCCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCGACGGCCCCTGAATTAGATCAGCTTGGTGGTATCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	CTTCAAATGGGATGACTCTAACTATATCAGGATTTCA
GTTTGTATCTTACCTATAAGGAATTGAAAC	ATTGAAATGATATGCGACTGGAAAGCTGCGGTGAT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CGCTTTCAAACGCCATTAAATCGTCACCTCCTCGGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCTGGAACACAAATGAAAGGAGTAATAACTGGATGAA
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCCGTCGAAGAAATGATTTCTTTGCTATTCCGGCTCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	AGAATATCCATTGAGTAATTGCACTCGACCATGAT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CACTATTTTTTGTTATTTCGAGTTGAGCAGCTGTTGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	ATGAAAGCACCTTCTTTAGAACGCGACGCTCTCATC
GTTTGTATCTTACCTATAAGGAATTGAAAC	GAAGTAATTAGTCAAGCAATTAGGTGGCAAGGCATGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCACGTTTCGAGATATGAGAAAAGAACACGGTCATTT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TGAAGCACCTTGGCGTGAAGAGAAAGTTAAAAAAG
GTTTGTATCTTACCTATAAGGAATTGAAAC	TGACTTCTGCCAAAATCGCTCTATCCTCATTGGCTT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CAGGCGCAGCGAACGCCTTATAGGCACAGCGAACGCC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCAAGCCGGCCGATTCGCATTCTTTTGGCGGACGAG
GTTTGTATCTTACCTATAAGGAATTGAAAC	TAAACTCAGTAATGTCTGGCTGCCAATCTGCAAGCA
GTTTGCATCTTACCTATAAGGATTAAAACC

>NZ_CP012712|1|1|9938-11228|CRT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CTTCATCCAGCGTCAAGTCGTTCATTTCACTTGTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTGGGTGGCGCTGTCGCGCACTCCCTTGACCCTCAA
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTTCACATTCCGGCGCTTTTGTTTCAAGAACAGCCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCGACGGCCCCTGAATTAGATCAGCTTGGTGGTATCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	CTTCAAATGGGATGACTCTAACTATATCAGGATTTCA
GTTTGTATCTTACCTATAAGGAATTGAAAC	ATTGAAATGATATGCGACTGGAAAGCTGCGGTGAT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CGCTTTCAAACGCCATTAAATCGTCACCTCCTCGGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCTGGAACACAAATGAAAGGAGTAATAACTGGATGAA
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCCGTCGAAGAAATGATTTCTTTGCTATTCCGGCTCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	AGAATATCCATTGAGTAATTGCACTCGACCATGAT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CACTATTTTTTGTTATTTCGAGTTGAGCAGCTGTTGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	ATGAAAGCACCTTCTTTAGAACGCGACGCTCTCATC
GTTTGTATCTTACCTATAAGGAATTGAAAC	GAAGTAATTAGTCAAGCAATTAGGTGGCAAGGCATGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCACGTTTCGAGATATGAGAAAAGAACACGGTCATTT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TGAAGCACCTTGGCGTGAAGAGAAAGTTAAAAAAG
GTTTGTATCTTACCTATAAGGAATTGAAAC	TGACTTCTGCCAAAATCGCTCTATCCTCATTGGCTT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CAGGCGCAGCGAACGCCTTATAGGCACAGCGAACGCC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCAAGCCGGCCGATTCGCATTCTTTTGGCGGACGAG
GTTTGTATCTTACCTATAAGGAATTGAAAC	TAAACTCAGTAATGTCTGGCTGCCAATCTGCAAGCA
GTTTGCATCTTACCTATAAGGATTAAAACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012712.1\|WP_013400094.1\|4315_4573_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_013400086.1\|17038_17287_-\|DUF1871-family-protein	unknown	unknown	gnl\|CDD\|370210
NZ_CP012712.1\|WP_013400090.1\|7963_8149_-\|H-type-small-acid-soluble-spore-protein	unknown	unknown	gnl\|CDD\|377962
NZ_CP012712.1\|WP_013400088.1\|14497_14731_+\|DUF378-domain-containing-protein	unknown	unknown	gnl\|CDD\|377214
NZ_CP012712.1\|WP_003248367.1\|8276_9272_+\|potassium-channel-protein	unknown	unknown	gnl\|CDD\|236711
NZ_CP012712.1\|WP_013400092.1\|5221_6400_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NZ_CP012712.1\|WP_013400087.1\|15254_16427_-\|aminotransferase	unknown	unknown	gnl\|CDD\|181082
NZ_CP012712.1\|WP_003248361.1\|14768_15134_-\|general-stress-protein-13	unknown	unknown	gnl\|CDD\|181215
NZ_CP012712.1\|WP_003248357.1\|16423_16924_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP012712.1\|WP_003248349.1\|19265_19469_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_013400093.1\|4633_5122_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_CP012712.1\|WP_042385161.1\|6405_7689_-\|purine/pyrimidine-permease	unknown	unknown	gnl\|CDD\|183124
NZ_CP012712.1\|WP_042385166.1\|18668_19193_-\|superoxide-dismutase-family-protein	unknown	unknown	gnl\|CDD\|238186
NZ_CP012712.1\|WP_003248353.1\|17392_18553_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|224090
NZ_CP012712.1\|WP_003248364.1\|11671_13021_-\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|184504
NZ_CP012712.1\|WP_003248366.1\|9268_9673_-\|YugN-like-family-protein	unknown	unknown	gnl\|CDD\|370164
NZ_CP012712.1\|WP_003248362.1\|13180_14344_-\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341466

Protein	Function_ID	Function_description	E-value
NZ_CP012712.1\|WP_013400086.1\|17038_17287_-\|DUF1871-family-protein	gnl\|CDD\|370210	pfam08958, DUF1871, Domain of unknown function (DUF1871). This set of hypothetical proteins is produced by prokaryotes pertaining to the Bacillus genus.	6.82674e-35
NZ_CP012712.1\|WP_013400090.1\|7963_8149_-\|H-type-small-acid-soluble-spore-protein	gnl\|CDD\|377962	pfam08141, SspH, Small acid-soluble spore protein H family. This family consists of the small acid-soluble spore proteins (SASP) of the H type (sspH). SspH are unique to spores of Bacillus subtilis and are expressed only in the forespore compartment during sporulation of this organism. The sspH genes are monocistronic and are recognized by the forespore-specific sigma factor for RNA polymerase - sigma-G. The specific role of this protein is unclear but is thought to play a role in sporulation under conditions different from that of the common laboratory tests of spore properties.	2.55553e-19
NZ_CP012712.1\|WP_003248367.1\|8276_9272_+\|potassium-channel-protein	gnl\|CDD\|236711	PRK10537, PRK10537, voltage-gated potassium channel protein.	1.25493e-16
NZ_CP012712.1\|WP_013400087.1\|15254_16427_-\|aminotransferase	gnl\|CDD\|181082	PRK07682, PRK07682, aminotransferase.	0
NZ_CP012712.1\|WP_013400092.1\|5221_6400_+\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.54057e-77
NZ_CP012712.1\|WP_003248361.1\|14768_15134_-\|general-stress-protein-13	gnl\|CDD\|181215	PRK08059, PRK08059, general stress protein 13; Validated.	6.72299e-64
NZ_CP012712.1\|WP_003248357.1\|16423_16924_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.44506e-34
NZ_CP012712.1\|WP_013400093.1\|4633_5122_-\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	2.03628e-56
NZ_CP012712.1\|WP_042385161.1\|6405_7689_-\|purine/pyrimidine-permease	gnl\|CDD\|183124	PRK11412, PRK11412, uracil/xanthine transporter.	8.87309e-63
NZ_CP012712.1\|WP_003248362.1\|13180_14344_-\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341466	cd08187, BDH, Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process. The butanol dehydrogenase (BDH) is involved in the final step of the butanol formation pathway in anaerobic micro-organism. Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process. Activity in the reverse direction is 50-fold lower than that in the forward direction. The NADH-BDH has higher activity with longer chained aldehydes and is inhibited by metabolites containing an adenine moiety. This protein family belongs to the so-called iron-containing alcohol dehydrogenase superfamily. Since members of this superfamily use different divalent ions, preferentially iron or zinc, it has been suggested to be renamed to family III metal-dependent polyol dehydrogenases. This family also includes E. coli YqhD enzyme, an NADP-dependent dehydrogenase whose activity measurements with several alcohols demonstrate preference for alcohols longer than C3. The active site of YqhD contains a Zn metal, and a modified NADPH cofactor bearing OH groups on the saturated C5 and C6 atoms, possibly due to oxygen stress on the enzyme, which would functionally work under anaerobic conditions.	0
NZ_CP012712.1\|WP_042385166.1\|18668_19193_-\|superoxide-dismutase-family-protein	gnl\|CDD\|238186	cd00305, Cu-Zn_Superoxide_Dismutase, Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene causes familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Cytoplasmic and periplasmic SODs exist as dimers, whereas chloroplastic and extracellular enzymes exist as tetramers. Structure supports independent functional evolution in prokaryotes (P-class) and eukaryotes (E-class) [PMID:.8176730].	1.41274e-47
NZ_CP012712.1\|WP_003248353.1\|17392_18553_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|224090	COG1168, MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism].	0
NZ_CP012712.1\|WP_003248364.1\|11671_13021_-\|glucose-6-phosphate-isomerase	gnl\|CDD\|184504	PRK14097, pgi, glucose-6-phosphate isomerase; Provisional.	0
NZ_CP012712.1\|WP_003248366.1\|9268_9673_-\|YugN-like-family-protein	gnl\|CDD\|370164	pfam08868, YugN, YugN-like family. This family of proteins related to B. subtilis YugN are functionally uncharacterized.	1.96652e-77
NZ_CP012712.1\|WP_013400088.1\|14497_14731_+\|DUF378-domain-containing-protein	gnl\|CDD\|377214	pfam04070, DUF378, Domain of unknown function (DUF378). Predicted transmembrane domain of unknown function. The majority of the family have two predicted transmembrane regions.	3.72143e-26

>NZ_CP012712.1|WP_003248366.1|9268_9673_-|YugN-like-family-protein
MIEIPSQLEGKTFPLFQLEQLLKPLGYTIGGNWDYDHGSFDYKIADEAGYQFLRVPFEAIDGQLDSHGTTVKLGRPFLLSHKYQSGVDDHAYAGNFGAAFNQFSEPQDPDAAVSEKYINVGKALVKDLENRLID
>NZ_CP012712.1|WP_003248367.1|8276_9272_+|potassium-channel-protein
MKNWDVFISYLRLPVFMRLLIIGTIMIVIFGTLIHFVEPATFRHVFDGIWWAIVTAATIGYGDMVPKTVAGKIVAISLILLGTGVITTYFASLSAAAVAKESALSNGQLRYMQKGHIIIVGWNERAREVIAKLSEYTPPVRCVIIDATLNELPVPFKNVHFIKGNPSYDDVLHKANATEAQMILITANQHKSEADADKDSILTLLAVKGIHPSIYAIVEILTEQNVNNAKRAGADEVIQTNLLASFTMANSLQSPGVSKAIIELLHQLHGKKLQLIAAEGPLIGKTFLESSEMLLDKRMILIGVMREEEGYINPSPHFLIEKGDRLFVITP
>NZ_CP012712.1|WP_013400090.1|7963_8149_-|H-type-small-acid-soluble-spore-protein
MDINRVKQIVSSPADIPVYYNGVSVWIDDYNEQEETATIHLRDGHLREQREVPVEELTEKQ
>NZ_CP012712.1|WP_042385161.1|6405_7689_-|purine/pyrimidine-permease
MRQVISSLQWFLFIISGSIVVPVTVASLYQLETADAMAFISRTFFVLAVAGLLQTAFGHRLPLNEGPAGIWWGIFILYASFGVALYGTRAETLRVLESALIMSGILFMLLSLLGIVDRLARLFTPTVTGTYLLLLAVQLSGSFLKGLLGVDETGKVSIVVAALSTIIIFLSLWMTNHPVLRQFSIIVSMITGWILFRLFGFAPSIHWTEKWFEFPKWFAFGPPRWEWGIVPTAFFVTLLLLTNMLASVKVVESVMKAEKANAGNPSPKRAGFMMGISHMISGVLAAIGSVPISGAASFIATSKITKRLPFVIACVLIMLMSLFMPAVSLFTAMPAAVGYAAIFPMFAGMITLGLKELEQNGGWKERAEQVSLPLFTGIGVMFVPSEAFAPLPPVIASVASNGLIVGTLLSILLEAVAGKKGATSASK
>NZ_CP012712.1|WP_013400092.1|5221_6400_+|MFS-transporter
MNRTAIVYLVSLAAFLGPFTQTIYTPILPEVTKDFGTSSFLVNLTISIFTFFLALMQMVYGPLTDTKGRRNVLLFGVFLYITASLGCFFSNSIYVLLVFRALQAIGIAAGSVVAATVIGDLFEGKARGKAMGTFQMMVSLGPVAGPIVGGFLGGRFNFHSVFLVLVLAGLLIWVGNFIFLQETKPEKQLAKTFRLRDFIPILRHRTGSSIILLGFIQYYAMYNFLVFLPSILTERYGLSAEEKGIAYLAMSCMIVIGSFIGGRIQGHWQERHIILATSYLNVASILLFLIVSHISISLLLISIMLFGLFLGTSLPVQTTLLTYVFQANRSTAIGVYNFFRYMGMALGPMIGSLLFSLGGYALVYGFTDIGFFFFSLWLTARVMFMNRPTSSI
>NZ_CP012712.1|WP_013400093.1|4633_5122_-|N-acetyltransferase
MIRNANIEDLPAIVQIYNETIPSRMVTADLEPVTVESRKAWFFNHDPHTRPLWVVELDGHVRAWLSFQSFYGRPAYRHTAEISIYISGAYRGKGIGKQLLQKAVEEAPSLDIKTLLGFIFAHNEPSLRLFMRFGFETWGHLPKVAELDGIERDLLIVGKRMV
>NZ_CP012712.1|WP_013400094.1|4315_4573_-|hypothetical-protein
MNVMPIRLFTIQDGEGFVADAFQCPVTGNLIYKSSGTPSVIAYNALTEEQIQYLEKYGFRRMNGASAAAASSPGSSTLEELLPEQ
>NZ_CP012712.1|WP_003248364.1|11671_13021_-|glucose-6-phosphate-isomerase
MTHIRFDYSKALAFFGEHELTYLRDAVKVAHHSLHEKTGVGNDFLGWIDLPVNYDKEEFARIQKAAAKIQADSDVLLVIGIGGSYLGARAAIEMLHHSFYNALSKEKRRTPQIIFVGNNISSTYMKDVMDLLEGKDFSINVISKSGTTTEPAIAFRIFRKLLEEKYGKEEARKRIYATTDRARGALKTLATAEGYETFIIPDDVGGRYSVLTAVGLLPIAVSGANIEEMMKGAAQAREDFSNSELEENAAYQYAAIRNILYNKGKTIELLINYEPALQYFAEWWKQLFGESEGKDQKGIFPASANFSTDLHSLGQYIQEGRRDLFETVLKVEKPRHELVIEAEENDLDGLNYLAGKTVDFVNTKAFEGTLLAHTDGGVPNLVITLPELNEYTFGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGYEEKKAELEKRLK
>NZ_CP012712.1|WP_003248362.1|13180_14344_-|iron-containing-alcohol-dehydrogenase
MENFSFQNPTKLIFGKGQIEQLKEEIPRYGKKILLVYGGGSIKRNGLYDEVMNLLNELKVEVTELPGVEPNPRLSTVRKGVEICKTEGIEFLLAVGGGSVIDCTKAIAAGAKYDGDPWDFITKKVKVFEALPFGTVLTLAATGSEMNAGSVITNWETKEKYGWNSPATFPQFSILDPTYTLTVPRDHTVYGIVDMMSHVFEQYFHHTANTPLQDRMCEAVLRTVMEAAPKLVNDLQNYELRETILYCGTIALNGLLQMGLRGDWATHNIEHAVSAVYDIPHAGGLAILFPNWMKHVLDENVSRFAQLAVRVFDVNPEGKAERDVALEGIEKLREFWSSIGAPSRLADYGIGEESLELIADKAMANGEFGKFKKLNRDDVLAILRASL
>NZ_CP012712.1|WP_013400088.1|14497_14731_+|DUF378-domain-containing-protein
MNALQRIALLLTIIGAINWGLIGFFQFDLVAAIFGGQDSVLSRIIYGLVGIAGLINLALLFKPAEELGRTEPKASRT
>NZ_CP012712.1|WP_003248361.1|14768_15134_-|general-stress-protein-13
MSNIEVGSIVKGKVTGIQPYGVFVELDRETQGLVHISEISHGFVKNIKDYVNVGDEITVKVLSIDPHTKRASLSMRAVEEGQRNMRKRHVKVKMSLNPGFHTLKEKLQEWIEQSKKEDLSK
>NZ_CP012712.1|WP_013400087.1|15254_16427_-|aminotransferase
MMQQTKKSYVSETVARLKPSGIRRFFDLASSMEGVVSLGVGEPDFVTSWSIREASILSLEQGYTSYTANAGLLELRQEIAAYLARKFHVEYDPEAEILVTVGASQAIDLALRATVNPGDEVIVVEPSFVSYGPLVTLAGGVPVPVGTTGEDHFKLRPDQIERVITDRTKALIVCSPNNPTGTVLHKEDLEAIAQIVKKHDLLVISDEIYAELTYDEPYISFAAVDGMRERTILVSGFSKGFAMTGWRLGFTAAPAEILQAMLKIHQYAIMCAPTMAQYAAIEALRNGEQDVEYMKKSYRRRRNYFVQSLNEIGLSCHMPGGAFYAFPSIRATGLTSEQFAEKLLLEEKVAVVPGSVFGAGGEGYIRCSYASSMEQLQEAIKRIKRFLERL
>NZ_CP012712.1|WP_003248357.1|16423_16924_-|Lrp/AsnC-family-transcriptional-regulator
MKLTEKEIEIIEILEKDARIPTETLAKMVSLSVDETEAILKKLEETKVIVQYTALVDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFPEVKSVYLMSGAYDLSVVIEGRSMSEIANFVSEKLSTLDSVISTTTHFILKKYKHDGTVFDQGDQDHRIVMAP
>NZ_CP012712.1|WP_013400086.1|17038_17287_-|DUF1871-family-protein
MNWQLLHAIRAWDPFGYGNDAYETEAVDVLQAVHDCDEPTTLAGKIQAIYEFSFERKIPLNECIKMAKSLLAMKQAAACSLP
>NZ_CP012712.1|WP_003248353.1|17392_18553_+|pyridoxal-phosphate-dependent-aminotransferase
MYSFDDVIDRRNTHSLKWDATERIFGVKDVLPMWVADMDFPAPPAVIEALNKRVEHGIFGYTIIPDSLKNAVKHWLQSRHQWEIETSWLSFSTGVIPAIATAIEAFTNEEDRIVVLTPVYPPLFQLVKKHRRTLVTSSLRLAETQYEIDWDDFEEKIRGAKLLVLCSPHNPGGRVWTKEELIKIGELCVEHGVIVISDEIHADLTLPPYQHVPFASIDPAFAEKSVTCIAPTKTFNLAGLQAAAAIIPNETLKRQFNNVQQRQGILTLNTFAVAGAEAAYQHGGEWLDALLPYLQKNINRLCSYIETNLPKLRVIRPEATYLVWVDCRPLGKTERQLKQLLLEKGKIAVEFGSKFGEEGRGFIRINIACPQKTLEDALHRLTAALQ
>NZ_CP012712.1|WP_042385166.1|18668_19193_-|superoxide-dismutase-family-protein
MFQKAGLLFAAAILFAVGCQKENVTNLEVNMINSAGDSIGTVKLTEQAKGMKLKLDLEGLPPGEHAIHIHEKGVCTKPDFQSAGNHYNPDGKKHGLLHPEGAHAGDLPNIIVKEDGTVNTELTAPNVTLKEGKKGTLLTKDGTAIVIHAGKDDGMTQPAGDAGERIACGEIKNR
>NZ_CP012712.1|WP_003248349.1|19265_19469_-|hypothetical-protein
MAVSYILSFMLYFPEDKREYIPAAVTCMIFLIAAILTTRLIIKISRYQEEKAKRLEEQLIRDNKNQE

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Crispr_ID: NZ_CP012712_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012712_2

355292-355988

Orphan

Consensus_repeat	Method
GTTTGTATCTTACCTATGAGGAATTGAAAC	PILER-CR
GTTTCAATTCCTCATAGGTAAGATACAAAC	CRISPRCasFinder
GTTTCAATTCCTCATAGGTAAGATACAAAC	CRT

10 spacers

The CRISPR arrays of NZ_CP012712_2

>merge|NZ_CP012712|2|355292-355988|PILER-CR,CRISPRCasFinder,CRT
GTTTCAATTCCTCATAGGTAAGATACAAACACGCATGGCGCGGGATTGCAGCGCATGTTATCAGCACGCGTTTCAATTCCTCATAGGTAAGATACAAACGTATAAGTGATGGCGCCGCTTGGATGTTTGTCATCCACGTTTCAATTCCTCATAGGTAAGATACAAACATATATTAAAAAGTGTAATATCATCTGCCAAAAATGGTTTCAATTCCTCATAGGTAAGATACAAACTCCCAAGCGCCTTTCCAATCACCTTTCAAGATAGCTGGTTTCAATTCCTCATAGGTAAGATACAAACTCTTCTCCTGTAATTTCCTTGTACTCAGCTAAAGTAAGTTTCAATTCCTCATAGGTAAGATACAAACGGTTACGGATTTGTAACGGAACTTGACCTCGCCAAGTTTCAATTCCTCATAGGTAAGATACAAACGACTAAAAACATACTAGAAAAAGCATTACGTCAATGTTTCAATTCCTCATAGGTAAGATACAAACAGTTGTTTGCTGAAACTTCTTTTTGTGATTTGGAAGCGTTTCAATTCCTCATAGGTAAGATACAAACATTTTGCGAACCATGTTTATTTTAGCCGAGCTGCTTTGTTTCAATTCCTCATAGGTAAGATACAAACTTTGCCTCCGGCTTTCTGCTGTTCCAAATAGCCTCGGTTTCAATTCCTCATAGGTAAGATACAAAC

>NZ_CP012712|2|2|355292-355988|PILER-CR
GTTTCAATTCCTCATAGGTAAGATACAAAC	ACGCATGGCGCGGGATTGCAGCGCATGTTATCAGCACGC
GTTTCAATTCCTCATAGGTAAGATACAAAC	GTATAAGTGATGGCGCCGCTTGGATGTTTGTCATCCAC
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATATATTAAAAAGTGTAATATCATCTGCCAAAAATG
GTTTCAATTCCTCATAGGTAAGATACAAAC	TCCCAAGCGCCTTTCCAATCACCTTTCAAGATAGCTG
GTTTCAATTCCTCATAGGTAAGATACAAAC	TCTTCTCCTGTAATTTCCTTGTACTCAGCTAAAGTAA
GTTTCAATTCCTCATAGGTAAGATACAAAC	GGTTACGGATTTGTAACGGAACTTGACCTCGCCAA
GTTTCAATTCCTCATAGGTAAGATACAAAC	GACTAAAAACATACTAGAAAAAGCATTACGTCAAT
GTTTCAATTCCTCATAGGTAAGATACAAAC	AGTTGTTTGCTGAAACTTCTTTTTGTGATTTGGAAGC
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATTTTGCGAACCATGTTTATTTTAGCCGAGCTGCTTT
GTTTCAATTCCTCATAGGTAAGATACAAAC	TTTGCCTCCGGCTTTCTGCTGTTCCAAATAGCCTCG
GTTTCAATTCCTCATAGGTAAGATACAAAC

>NZ_CP012712|2|2|355292-355988|CRISPRCasFinder
GTTTCAATTCCTCATAGGTAAGATACAAAC	ACGCATGGCGCGGGATTGCAGCGCATGTTATCAGCACGC
GTTTCAATTCCTCATAGGTAAGATACAAAC	GTATAAGTGATGGCGCCGCTTGGATGTTTGTCATCCAC
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATATATTAAAAAGTGTAATATCATCTGCCAAAAATG
GTTTCAATTCCTCATAGGTAAGATACAAAC	TCCCAAGCGCCTTTCCAATCACCTTTCAAGATAGCTG
GTTTCAATTCCTCATAGGTAAGATACAAAC	TCTTCTCCTGTAATTTCCTTGTACTCAGCTAAAGTAA
GTTTCAATTCCTCATAGGTAAGATACAAAC	GGTTACGGATTTGTAACGGAACTTGACCTCGCCAA
GTTTCAATTCCTCATAGGTAAGATACAAAC	GACTAAAAACATACTAGAAAAAGCATTACGTCAAT
GTTTCAATTCCTCATAGGTAAGATACAAAC	AGTTGTTTGCTGAAACTTCTTTTTGTGATTTGGAAGC
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATTTTGCGAACCATGTTTATTTTAGCCGAGCTGCTTT
GTTTCAATTCCTCATAGGTAAGATACAAAC	TTTGCCTCCGGCTTTCTGCTGTTCCAAATAGCCTCG
GTTTCAATTCCTCATAGGTAAGATACAAAC

>NZ_CP012712|2|2|355292-355988|CRT
GTTTCAATTCCTCATAGGTAAGATACAAAC	ACGCATGGCGCGGGATTGCAGCGCATGTTATCAGCACGC
GTTTCAATTCCTCATAGGTAAGATACAAAC	GTATAAGTGATGGCGCCGCTTGGATGTTTGTCATCCAC
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATATATTAAAAAGTGTAATATCATCTGCCAAAAATG
GTTTCAATTCCTCATAGGTAAGATACAAAC	TCCCAAGCGCCTTTCCAATCACCTTTCAAGATAGCTG
GTTTCAATTCCTCATAGGTAAGATACAAAC	TCTTCTCCTGTAATTTCCTTGTACTCAGCTAAAGTAA
GTTTCAATTCCTCATAGGTAAGATACAAAC	GGTTACGGATTTGTAACGGAACTTGACCTCGCCAA
GTTTCAATTCCTCATAGGTAAGATACAAAC	GACTAAAAACATACTAGAAAAAGCATTACGTCAAT
GTTTCAATTCCTCATAGGTAAGATACAAAC	AGTTGTTTGCTGAAACTTCTTTTTGTGATTTGGAAGC
GTTTCAATTCCTCATAGGTAAGATACAAAC	ATTTTGCGAACCATGTTTATTTTAGCCGAGCTGCTTT
GTTTCAATTCCTCATAGGTAAGATACAAAC	TTTGCCTCCGGCTTTCTGCTGTTCCAAATAGCCTCG
GTTTCAATTCCTCATAGGTAAGATACAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012712.1\|WP_042384771.1\|362544_363561_-\|sugar-binding-protein	unknown	unknown	gnl\|CDD\|380537
NZ_CP012712.1\|WP_013876140.1\|358105_359404_-\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NZ_CP012712.1\|WP_042384752.1\|344216_344996_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224041
NZ_CP012712.1\|WP_013399878.1\|366189_367554_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|178402
NZ_CP012712.1\|WP_003247761.1\|350923_351937_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|236863
NZ_CP012712.1\|WP_042384763.1\|356249_357071_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP012712.1\|WP_042384768.1\|359548_361099_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|227095
NZ_CP012712.1\|WP_080695340.1\|361076_362552_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NZ_CP012712.1\|WP_042384773.1\|367571_368549_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NZ_CP012712.1\|WP_035501691.1\|346290_347259_+\|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270275
NZ_CP012712.1\|WP_042384766.1\|357070_358042_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP012712.1\|WP_003247760.1\|351926_352592_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NZ_CP012712.1\|WP_042384761.1\|353515_354913_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274819
NZ_CP012712.1\|WP_003247778.1\|343810_344179_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238431
NZ_CP012712.1\|WP_013399879.1\|364561_365998_-\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NZ_CP012712.1\|WP_042384756.1\|348094_349423_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274819
NZ_CP012712.1\|WP_042384758.1\|349520_350846_+\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP012712.1\|WP_003247768.1\|347287_348064_+\|aliphatic-sulfonate-ABC-transporter-permease-SsuC	unknown	unknown	gnl\|CDD\|183100
NZ_CP012712.1\|WP_013399880.1\|363802_364537_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP012712.1\|WP_042384753.1\|345106_346225_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274652

Protein	Function_ID	Function_description	E-value
NZ_CP012712.1\|WP_042384771.1\|362544_363561_-\|sugar-binding-protein	gnl\|CDD\|380537	cd06314, PBP1_tmGBP, periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs. Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs from other bacteria. They are members of the type 1 periplasmic binding protein superfamily which consists of two domains connected by a three-stranded hinge. TmGBP is specific for glucose and its binding pocket is buried at the interface of the two domains. TmGBP also exhibits high thermostability and the highest structural similarity to E. coli glucose binding protein (ecGBP).	4.65991e-113
NZ_CP012712.1\|WP_013876140.1\|358105_359404_-\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	5.15656e-56
NZ_CP012712.1\|WP_042384752.1\|344216_344996_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	6.19937e-112
NZ_CP012712.1\|WP_013399878.1\|366189_367554_-\|FAD-binding-protein	gnl\|CDD\|178402	PLN02805, PLN02805, D-lactate dehydrogenase [cytochrome].	1.09948e-128
NZ_CP012712.1\|WP_003247761.1\|350923_351937_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|236863	PRK11153, metN, DL-methionine transporter ATP-binding subunit; Provisional.	0
NZ_CP012712.1\|WP_042384763.1\|356249_357071_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	9.76829e-80
NZ_CP012712.1\|WP_042384768.1\|359548_361099_-\|response-regulator-transcription-factor	gnl\|CDD\|227095	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms].	1.03838e-82
NZ_CP012712.1\|WP_080695340.1\|361076_362552_-\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	3.28724e-54
NZ_CP012712.1\|WP_042384773.1\|367571_368549_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	0
NZ_CP012712.1\|WP_035501691.1\|346290_347259_+\|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270275	cd13557, PBP2_SsuA, Substrate binding domain of sulfonate binding protein, a member of the type 2 periplasmic binding fold superfamily. This subfamily includes the sulfonate binding domains SsuA found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.30874e-122
NZ_CP012712.1\|WP_042384766.1\|357070_358042_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.30418e-79
NZ_CP012712.1\|WP_003247760.1\|351926_352592_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	1.13708e-94
NZ_CP012712.1\|WP_042384761.1\|353515_354913_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP012712.1\|WP_003247778.1\|343810_344179_+\|hypothetical-protein	gnl\|CDD\|238431	cd00851, MTH1175, This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This domain is a predicted small-molecule-binding domain (SMBD) with an alpha/beta fold that is present either as a stand-alone domain (e.g. NifX and NifY) or fused to another conserved domain (e.g. NifB) however, its function is still undetermined.The SCOP database suggests that this domain is most similar to structures within the ribonuclease H superfamily. This conserved domain is represented in two of the three major divisions of life (bacteria and archaea).	0.00032433
NZ_CP012712.1\|WP_013399879.1\|364561_365998_-\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	0
NZ_CP012712.1\|WP_042384756.1\|348094_349423_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP012712.1\|WP_042384758.1\|349520_350846_+\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	5.79157e-60
NZ_CP012712.1\|WP_003247768.1\|347287_348064_+\|aliphatic-sulfonate-ABC-transporter-permease-SsuC	gnl\|CDD\|183100	PRK11365, ssuC, aliphatic sulfonate ABC transporter permease SsuC.	7.06173e-105
NZ_CP012712.1\|WP_013399880.1\|363802_364537_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	1.14066e-62
NZ_CP012712.1\|WP_042384753.1\|345106_346225_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274652	TIGR03565, alk_sulf_monoox, alkanesulfonate monooxygenase, FMNH(2)-dependent. Members of this protein family are monooxygenases that catalyze desulfonation of aliphatic sulfonates such as methane sulfonate. This enzyme uses reduced FMN, although various others members of the same luciferase-like monooxygenase family (pfam00296) are F420-dependent enzymes. [Central intermediary metabolism, Sulfur metabolism].	4.9574e-119

>NZ_CP012712.1|WP_042384761.1|353515_354913_+|LLM-class-flavin-dependent-oxidoreductase
MAKQIILNAFEMASAMHNSHGLWKHPESKRQRGYKDIEYWIKMAKLLERGKFDAVFFADVLGVYDTYRQSKAPSIRDGLQFPVNDASLVIPVMASVTKHLSFALTVSTTYEHPFNIARRFSTLDHLTKGRIAWNVVTSYLPNAARNFGLPEMIKHDQRYDIADEFLEVTYKLWEGSWEDDAFIEDKQNGILIDPDKVHEIHHAGKFFAVEGPHLCEPSPQRTPVIYQAGTSERGREFAAKHAECVFVGGPTPERIKYYTNDIKRRAEKYGRNPDNIKVFAFLTVIVGKTTEEAEQKFAELNHLWSPDASKAQFSGASGYDLAEYETKDLNAPFEFKNTEHGHYKAASLTKDASKKLSIGEALNKLEQLDRESIIVGNPEEVADAIQHRFEESGVDGFNLNHLITPSSLEDFIELVIPILQKRGLYKTEYKPGTLREKLFNYGSSLLPEDHPGSAYRSNRSKSFIV
>NZ_CP012712.1|WP_003247760.1|351926_352592_+|ABC-transporter-permease
MLLDALIRLIPELNKAFLETIYMVAISLFAAVVAGLPLGILLFVTDRGLFLENIAVKSVLGFIVNMIRSIPFIILLVGLLPLTKLITGTTIGPTAASVSLSVAAVPFFARIVETSLREIEKGVIEAAIAVGATPWMIIKDVLLPETRPGIVHGITITTISLVGYSAMAGIVGGGGIGDLAIRFGYYRYDNTIMITTIVILICLVQIIQFIGDRIARLVDKR
>NZ_CP012712.1|WP_003247761.1|350923_351937_+|methionine-ABC-transporter-ATP-binding-protein
MIEIKNVTKIYSMKKKQVVGVDNISLTIQDGEIFGIIGYSGAGKSTLLRCLNLLERPTSGQVIIDGVDLTSLNDKQLRQARLKIGMIFQHFYLISSKTVFENVAFALKAAKKPKEEIEKRVNELLEMVGLSDKRDAYPSQLSGGQKQRVGIARALANDPTVLLCDEATSALDPSTTKSILALLKKINRELGITIVLITHEMEVVKEICDRVAVMQNGRIIELGTVYDIFTNPQEELTKSFINSVLRFEIPDHLLQKRTGTMVKIHFKGEIAEEAVISDMLQSFKVKGNILHGKIEYIQEIPLGIFVMELIGEQEEIQRAIDYISQRTNALEVIAYAA
>NZ_CP012712.1|WP_042384758.1|349520_350846_+|acyl-CoA/acyl-ACP-dehydrogenase
MLRNSQSSGTSFLLPLFNWAHAKECIAGQKYKKGEIMLSIASKKNHRSYLSDELSRKFVQNERQEFLLHLASELAEQFHKTADIIDQEGRFPFENFQKLKDCNYQSLTIPKQYGGEEISLYEFLLMQERLSQGDASTALCIGWHLGVIYDLRERQTWDSEKFKWLCHEVVQNKVLINRVATEDGTGSPTRGGKPETVAVKRNGKWVITGRKSFASMAIALDYSLVTATIQESGKVGSFLVDHRLQGVSVEETWDMIGMRGTRSDDLVLDQVELPEDALVELDQLESPKGNMGRAWLLHVPACFLGIAIAARNYAISFASEYQPNSLPGPIKDVPEVQRKIGEMDLELLKARHTLYSVAHRWDTYPEKRMEMSGELAAAKHIAVNSANKVVDLAMRIVGARSLQKSSPLQRYYRDVRAGLHNPPMDDAVISLLAKQALQSFH
>NZ_CP012712.1|WP_042384756.1|348094_349423_+|LLM-class-flavin-dependent-oxidoreductase
MKKKQMKLGVFLMGTGHHIASWRHPHVQADGCEDFAFFHKIAKIAEKGKLDMLFLSDGLSFNELSHPAELVRFEPITLLAALSVVTSHIGLAATATTTYNEPFHIARKFSSLDHLSKGRAAWNVVTSYYEDEAKNFSQDAHLDHHLRYERAKEFVEVVKGLWDSWEKDALVRDKQSGVYFDPKKLHPLNHKGKYFSVKGPLNSSRSPQGRPVLIQAGSSEDGVNFAAQIADVIFTAQQTLEEAQHFYRKVKKKAAEFGRNPDEVIIMPGVSPYIGNTEQEAREKYEQLQELIVPEIGLAFLSDYLGGIDLSRYSLDDPLPDEIPETNGNKSRRKLIIDLARRENLTIGELYKRIAGSRGHRIIFGTPEQIADQLEEWIIHEGADGFNLMFPYYPDGLSEFVDQVIPILQERGLFRKEYEGTTLREHLGLPEPESRYSPAPSQ
>NZ_CP012712.1|WP_003247768.1|347287_348064_+|aliphatic-sulfonate-ABC-transporter-permease-SsuC
MKKIRKIYDQIAPWIVPILLLIAWQLFSAIGWISERVLPSPLEVLLAAITLTKNGELFTNIGVSFTRAFIGFVIGGGIGLILGLLNGIYPVAEKYLNTTIQMFRNIPHLALIPIVILWFGVGEEAKIFLVIIGVFFPIYINTYHGVISVPKDLIEMGKVYGLSKWILFSNVIFPSALPSILVGLRYALGVMWLTLIVAETVAASSGIGYMAMNAREFMQLDVVVLSILLYALLGKLADSLAKCLERYFLKWNPAYQKK
>NZ_CP012712.1|WP_035501691.1|346290_347259_+|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein
MRSMKRSKHILWIIHFLVFSLLLSSCGKAEETGGKNKEIHIGYQKNGTTLLLKHKQELQKELEKEGYKVTWSEFNTGSSILEALNAGSIDFAGAGDIPSIFALEKGSNFNYIASEPSSPSSEGILVRKDSGIQSLEDLKGKRIAFNKASIAQYLLTKALDSAGLSMDDVEPVYLNPPEASIAFEQGEVDAWVVWDPYMTVAESKGHIILKDATGIVPYRTFYFSTPEIAKEHPEIVKKFVEHLSNIGKQINHDPTEAAALLQKATNIPAETWEKVLNNKKSDVHFMDEKAVRDLQTEADDLLKIGLIKKQVQIEDYVWYPEK
>NZ_CP012712.1|WP_042384753.1|345106_346225_+|LLM-class-flavin-dependent-oxidoreductase
MVEFITMAPTSGDSTLVGLANNSSKLNSWTGTDENAERPPTQEYIKAIAQAAEKGGFSTLLLPTGTGCLDSLAVAANLIAYTSKLKFLFAIRPGFIAPATFAKQFATVDYWSNGRALVNIVTGGSPVELASEGDYLDHDTRYKRTREYMQILKKLFTEESVDYEGEFFTLKGASLFPKPVKTPLIYFGGASEIAKEVAAEEADVYMMWGETFENTKQRLEEMKQRAAKHNRTLSYSVSFQVILGNTEEEAWEKANKLISKVSASILAKKEEMIAKGDSIGAKRLHQLMESSKERNFKIGPNLWAGLTQVLSGNSIALVGTPEQIAERIVELVELGFDKVLLRGFPHLETIEQLGELVIPKVREKLAQKQLVK
>NZ_CP012712.1|WP_042384752.1|344216_344996_+|ATP-binding-cassette-domain-containing-protein
MPETSGVELSIHQLEKSFGHLHVLRKIDLQIASGEFVAIVGKSGCGKSTLLRLIAGLEKATSGEIRQNGKIIKELNPQARIMFQEARLLPWRSVLENVGVGLRLQKDWKQRAIWALKQVGLEERAHDWPSVLSGGQKQRVSLARALAAQPQLLLLDEPLGALDALTRMEMQALIEEIWQQQKFTALLVTHDVNEAITLADRVVLIEKGTIKMDLPIPLPRPRNRSDSAFIELEEKVLAHVLEKTSLKKETENLKSVANE
>NZ_CP012712.1|WP_003247778.1|343810_344179_+|hypothetical-protein
MRSMIIALVLDHDENIVPIIDGTIVRIYDTESGKYQDYPNPALHLKEGRRGAVLRFAQEKGAAVFASPPKTFCELSYAKAQENHIQFCQLDGPITFDAFQELFNNGKILIKDHLPAQEIVPS
>NZ_CP012712.1|WP_042384763.1|356249_357071_-|carbohydrate-ABC-transporter-permease
MRQRAWSRLFLYAICIFMSLFFLMPVYVMLVTSVKPLDEVTLADMWKLPSAFDWSSYQTAFAKLAPNFWNSVYLVVPATLLSAILGALNGYVLSKWKFKGADTIFTLILFGMFIPYQSILIPLIQFLREIGLYNTIPGLIFVHVVYGIPITTLMFRNFYAAIPDEMIESAKIDGAGFLRIFRYIMLPLSVTGFVVVAIWQFTNIWNEFLFAVTITTSSQQPIMVALQNLSGSQIVQWNVQMAGALLAALPTLLVYIFLGKYFVRGLLAGSVKG
>NZ_CP012712.1|WP_042384766.1|357070_358042_-|sugar-ABC-transporter-permease
METVKTVSERSVTAVPAPRKKRKWTADHWLAIAFLTPSVVLIFIFVYGFIGWTGYVSLSNWNSLVPDLSFAGLKNYVYLFHDFRFQADLRNTLVFTILFIGVVIVLGQLLAVLLDQKLRGESLFRNIFFFPMALSFVVTGVVWQWLLNPSTGVNLFLKKIGFDSKWYTDTTIFGGFHLGKIEFGVPVAIVAVVIAAVWQMTGFAVAMYLAGLRAIPEEVREAARIDGATELQIYRKIIIPLLRPITVSVIIIMAHISLKIFDLIYAMTGPGANFVTDVPGVYMFETTFRGNYYANGAAIAVIMLLSVAIFIVPYLISGRKGGS
>NZ_CP012712.1|WP_013876140.1|358105_359404_-|carbohydrate-ABC-transporter-substrate-binding-protein
MKKKRLWLSLALVAGLALSGCNSDSASNSNSKEDQGGSKGHEKLEIFSWWTGAGEEDGLKALLKLFQEKYPDIPVENAAVAGGAGTNAKAVLASRMQGNDPPATFQVHGGAELNEGWVAAGKMEPLNDLYEKEGWMDKFPKSLIDMVSKDGKIYSVPVNIHRGNVLWYNKKIFAENGLEPPKTFDEFFQVADKLKAKGITPLALGDKEPWTATHIFETVLLGTLGTEDYKKLWTGELPFDDPKVKEAVNTFKKMLDYVNEDHSSRNWQDAAQLVGKGEAAMNIMGDWVKGYFVNDLKLKVNEDFGYVPTPNTEGKFMVITDTFGLPKGVKNPDDVKKFLSVLGSVEGQDAFNPLKGSIPARIDADTSKYDEYGKQTMEDFKTAELAPSLAHGSAAPEGFVTKVNQAVNIFVTQKDTKTFIDTLVSASAELKK
>NZ_CP012712.1|WP_042384768.1|359548_361099_-|response-regulator-transcription-factor
MKIAIVDDEALERKALQKMIRGHLPTMEVIAEAANGREAVEVADQYKPDVMLMDIKMPGIDGLEAIELIRRKHPEIKFIIVSAFDTFDYAKQAMRHGVKEYLLKPSRKEEVVGALQRVYDELMEERRKEEENRELQQRVRQLQKLVEKEWLSVLMLEEVSSQEWKQWETLLPFSIDAGMFMVIQFPSGEKREDWKNWIEQVLSEKETTHYIIGKMVDGQMPVLFFHDVAVKAFSWKPVIQSLSLELIQQFERQYGTALYIGLGSPASRLEELRHSYYEALAAAQYYASQKKAKSGFLPKKSVLAAASGHIEKEKRLLDAVRQGDLEQALLQCYTYIEEEAAHHPLSVVQQKLEETFVLLGRMFADFGIAYERTATFHSCRSPEELKKTAAEQLRHMTCHILAWRHQQANGKLGKAKDYIDEHYHHPLTLEEVAEYVGISPCYFSKLFKDRFGMTFIDYVTDVRIARAKKEMADPNKSLKEICFLVGYNDPNYFSRVFKKHTGMSPSEYRKKLHSAT
>NZ_CP012712.1|WP_080695340.1|361076_362552_-|sensor-histidine-kinase
MIKIRTKALFYFGIFIVLLNGTVFFFYQSSEDIVTDYDYSMRRLLLFNEISQRTNRMVEQLNAYLTEKDGRYFREYERQYRWLQQHRRQVGETLSNRNNRLLVKNYEHMIESLLEEGALTVYHFQAGNISLYSSHLHEAMKIASFIQETTLSLIDEELTTYQHFYNEVEARNRYFRYMGIGLSMTTFLLGVLLAVWFSGGLTRPIARLSRAAREIASGKLDGPDVISTTNDELKLLTDTFNDMRRNLKRLIEEMKQKSELDRLVKELELKSLQGQMNPHFLFNTLNAVAKMAYLEEANQTSRLIEAIAAILRYNLGDLQRTVTLADEVRIAHEYFFIQQTRFFDRIKFSMDVEESCLSLPIPPLTLQPLIENAFIHGIESYEKGAVLSLTVEKKKDLVVVEIRDNGVGMSEEVKEKLTAFIKGEEAGSILHGQTRGHSTGIGMYNVIRRLQLFYGMQDVIEIESAAGKGTTIRLLLPITKGGEANENRHCR
>NZ_CP012712.1|WP_042384771.1|362544_363561_-|sugar-binding-protein
MSRTWWKWVIYAGSIAALIVSASFTIYCAWKVYAYHQPGEGAAAEAEKNAFHFVLVPEELDNDYWRLVEQGAKAAAKETGVYLEYAGPRQANIDEHIHILEKAAASKVDGIMTQGLTEKEFTPVINHIVEKNIPVVTIDTDAPTSKRTAYIGTDNYYAGFIAGRALAEDMHGKANVAIITGSFTASNQQLRVQGFKDAVKEEKGIHIVAVEESHITRVQAAEKAYNILKKHPEVNAFYGTSALDAIGIAKVVEQFHREKGTYIIGFDTLPETIRYLQKGTIHATVVQEPYEMGYRAVKMMVDIRKGNNVPSVINTETKVIRKQDLPLRPSRNYEVNHD
>NZ_CP012712.1|WP_013399880.1|363802_364537_+|MurR/RpiR-family-transcriptional-regulator
MFTPEQIARFSELDYIIYNYVTKHANEVVYMRIRELAEEVHVSPPTILRFCRKVGCDGFSEFKTKLKLYLQQNERSFITNAQDTLTEFFERTLKIDYQQTIREAAAAIARADNVIFVGSGSSGILAEYGSRYFSALKKFSVYIKDPFFPIYGHYFNNCVVIALSVSGETSYTLSQVHRFKEKGSTIISITNRKHCSLANMSDYNLTYYVNTEFVEQTNITTQIPVIYLLESLAKEMYRMLNKPT
>NZ_CP012712.1|WP_013399879.1|364561_365998_-|glycoside-hydrolase-family-1-protein
MEHKQLRPFPDRFLWGSASAAYQVEGAWNEDGKGLSVWDVFAKQPGRTFKGTNGDVAVDHYHRYKEDVALMAEMGLKAYRFSVAWSRVFPNEKGEINEKGLQFYDNLINELLKHNIEPIITLYHWDVPQALMDEYGAWESRQIIDDFHDYAVTLFQRFGDRVKYWVTLNEQNLFITFGYRLGLHPPGVKDAKRMYEANHIANLANAKVIQAFRHYVPDGKIGPSFAYSPMYPYDCRPENVLAWENAEEFQNHWWMDVYVWGTYPQAAWNYLEQQGWAPTIKSGDMELLKAGKPDFMGVNYYRSQTVQYNPLDGVGEGVMNTTGKKGTSTESGIPGLFKIVRNPHLEATNWDWEIDPVGLRIGLRRIANRYGLPVFITENGLGEFDKLEDGDIVNDDYRIDYLRRHIQEIQRAITDGVDVIGYCTWSFTDLLSWLNGYQKRYGFVYVNRDDESEKDLRRIKKKSFYWYKQVIASNGKEL
>NZ_CP012712.1|WP_013399878.1|366189_367554_-|FAD-binding-protein
MGVYEDLLEQIGDRERVTVNETVLEQHSKGIAYHAPRKPDVVVFPKTAAEVSAVLAYANERRIPVTPFGAGSSLEGHIIPVQGGITLNLTMMNHIIDIRPDDFLAIVEPGVTRMQLNQALKKYGLFFPVDPGADATLGGMAATNASGTNSVKYGVMRDQVLGLEVVLADGKIVHTGGMAAKSSAGYDLTGLFVGSEGTLGVFTKMIVRLQGIPEATNAIKASFPTLTAAAQAAALLLKAGVSPGKIELVDEQTIQAVNQYKQTNYPEAPTLFIELSGSAASVKDGTEVVKEWCAAENAVSFETEDDPAGRAKLWEARHHAAFAIQAAHPGKTMLSTDVCVPVSKLPEAIAETRKLVDEYGITAAIFGHVGDGNYHTVLTFDPADAEEVKRVEEINARIVRYALSHGGTCTGEHGIGIGKRHFLYEEHRDSVPLMQGIKRLFDPNGIMNPGKIFL
>NZ_CP012712.1|WP_042384773.1|367571_368549_-|alpha-ketoacid-dehydrogenase-subunit-beta
MAEKTMIQAINEAIRQEMERDERVIVLGEDVGKNGGVFRATDGLFEQFGDRRVFDTPLAESGIIGTSIGLAVNGFRPVAEIQFLGFAYQAMDQLAAQAARLRFRSAGRFTCPLVVRSPYGGGVRTPELHSDALEALFTHSPGLKVVMPSNAFDAKGLLISAIRDEDPVLFLEPMKLYRALRMEVPDEPYEIPLGTARVVKEGEDVTIISWGATVPLVAKLAEEMKEKGIDAEVIDLRSLQPLDIDAIVQSVEKTGRVMIVHEAVKTNGFGAEIAALISERALFSLSAPIVRVTGYDTPYPVPSVEDEWLPNAARIVEGVQMLMRY

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Crispr_ID: NZ_CP012712_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012712_3

389075-389162

Orphan

Consensus_repeat	Method
TTTGTATTCAAACAATCAGCCAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012712_3

>merge|NZ_CP012712|3|389075-389162|CRISPRCasFinder
TTTGTATTCAAACAATCAGCCAGCTGATTCTGGAAGCAAAAGGGAAGAAAGCGTCCGAATTTCGTTTGTATTCAAACAACCAGCCAGC

>NZ_CP012712|3|3|389075-389162|CRISPRCasFinder
TTTGTATTCAAACAATCAGCCAGC	TGATTCTGGAAGCAAAAGGGAAGAAAGCGTCCGAATTTCG
TTTGTATTCAAACAACCAGCCAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012712.1\|WP_013876128.1\|387240_388542_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NZ_CP012712.1\|WP_003247693.1\|398939_399650_-\|DsbA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|239322
NZ_CP012712.1\|WP_003247717.1\|379531_380695_+\|DUF819-domain-containing-protein	unknown	unknown	gnl\|CDD\|227792
NZ_CP012712.1\|WP_003247697.1\|395075_397037_+\|LTA-synthase-family-protein	unknown	unknown	gnl\|CDD\|224287
NZ_CP012712.1\|WP_148259566.1\|388517_388754_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_003247699.1\|393271_394612_-\|TrkH-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|273349
NZ_CP012712.1\|WP_003247718.1\|379104_379452_+\|DUF3870-domain-containing-protein	unknown	unknown	gnl\|CDD\|372419
NZ_CP012712.1\|WP_003247692.1\|399791_400484_-\|DUF1129-family-protein	unknown	unknown	gnl\|CDD\|181074
NZ_CP012712.1\|WP_042384782.1\|381811_382819_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NZ_CP012712.1\|WP_003247700.1\|391005_392841_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP012712.1\|WP_003247695.1\|397050_398376_-\|S8-family-peptidase	unknown	unknown	gnl\|CDD\|173812
NZ_CP012712.1\|WP_003247710.1\|384407_384608_-\|DUF3311-domain-containing-protein	unknown	unknown	gnl\|CDD\|371707
NZ_CP012712.1\|WP_042384790.1\|401364_402591_-\|threonine-synthase	unknown	unknown	gnl\|CDD\|181283
NZ_CP012712.1\|WP_003247691.1\|400480_400813_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP012712.1\|WP_003247712.1\|382938_384411_-\|sodium:solute-symporter	unknown	unknown	gnl\|CDD\|223664
NZ_CP012712.1\|WP_042384785.1\|385868_387098_-\|Zn-dependent-hydrolase	unknown	unknown	gnl\|CDD\|236456
NZ_CP012712.1\|WP_003247702.1\|390236_390896_-\|sporulation-membrane-protein-YtaF	unknown	unknown	gnl\|CDD\|274321
NZ_CP012712.1\|WP_003247709.1\|384659_385844_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|349941
NZ_CP012712.1\|WP_003247704.1\|389167_390127_-\|sporulation-protein	unknown	unknown	gnl\|CDD\|369195
NZ_CP012712.1\|WP_042384779.1\|380713_381790_+\|dipeptide-epimerase	unknown	unknown	gnl\|CDD\|239435

Protein	Function_ID	Function_description	E-value
NZ_CP012712.1\|WP_013876128.1\|387240_388542_-\|transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	0.00114778
NZ_CP012712.1\|WP_003247693.1\|398939_399650_-\|DsbA-family-oxidoreductase	gnl\|CDD\|239322	cd03024, DsbA_FrnE, DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins.	1.98941e-103
NZ_CP012712.1\|WP_003247717.1\|379531_380695_+\|DUF819-domain-containing-protein	gnl\|CDD\|227792	COG5505, COG5505, Predicted integral membrane protein [Function unknown].	1.09768e-109
NZ_CP012712.1\|WP_003247697.1\|395075_397037_+\|LTA-synthase-family-protein	gnl\|CDD\|224287	COG1368, MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane].	0
NZ_CP012712.1\|WP_003247700.1\|391005_392841_-\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.23617e-24
NZ_CP012712.1\|WP_003247699.1\|393271_394612_-\|TrkH-family-potassium-uptake-protein	gnl\|CDD\|273349	TIGR00933, Trk_system_potassium_uptake_protein_trkH., potassium uptake protein, TrkH family. The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds].	3.42578e-110
NZ_CP012712.1\|WP_003247718.1\|379104_379452_+\|DUF3870-domain-containing-protein	gnl\|CDD\|372419	pfam12986, DUF3870, Domain of unknown function (DUF3870). A family based on the C-terminal domain of 3KOG which shows structural similarity to pore-forming proteins, suggesting it may have a lytic function.	2.03319e-42
NZ_CP012712.1\|WP_003247692.1\|399791_400484_-\|DUF1129-family-protein	gnl\|CDD\|181074	PRK07668, PRK07668, hypothetical protein; Validated.	5.74452e-09
NZ_CP012712.1\|WP_042384782.1\|381811_382819_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	5.66052e-34
NZ_CP012712.1\|WP_003247695.1\|397050_398376_-\|S8-family-peptidase	gnl\|CDD\|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	4.51964e-126
NZ_CP012712.1\|WP_003247710.1\|384407_384608_-\|DUF3311-domain-containing-protein	gnl\|CDD\|371707	pfam11755, DUF3311, Protein of unknown function (DUF3311). This is a family of short bacterial proteins of unknown function.	1.21887e-13
NZ_CP012712.1\|WP_042384790.1\|401364_402591_-\|threonine-synthase	gnl\|CDD\|181283	PRK08197, PRK08197, threonine synthase; Validated.	0
NZ_CP012712.1\|WP_003247691.1\|400480_400813_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	3.81002e-25
NZ_CP012712.1\|WP_003247712.1\|382938_384411_-\|sodium:solute-symporter	gnl\|CDD\|223664	COG0591, PutP, Na+/proline symporter [Amino acid transport and metabolism / General function prediction only].	3.27026e-71
NZ_CP012712.1\|WP_042384785.1\|385868_387098_-\|Zn-dependent-hydrolase	gnl\|CDD\|236456	PRK09290, PRK09290, allantoate amidohydrolase; Reviewed.	0
NZ_CP012712.1\|WP_003247702.1\|390236_390896_-\|sporulation-membrane-protein-YtaF	gnl\|CDD\|274321	TIGR02840, conserved_hypothetical_protein, putative sporulation protein YtaF. This protein family was identified, at the time of the publication of the Carboxydothermus hydrogenoformans genome, as having a phylogenetic profile that exactly matches the subset of the Firmicutes capable of forming endospores. The species include Bacillus anthracis, Clostridium tetani, Thermoanaerobacter tengcongensis, Geobacillus kaustophilus, etc. This protein, previously named YtaF, is therefore a putative sporulation protein. [Cellular processes, Sporulation and germination].	5.33075e-55
NZ_CP012712.1\|WP_003247709.1\|384659_385844_-\|amidohydrolase	gnl\|CDD\|349941	cd08021, M20_Acy1_YhaA-like, M20 Peptidase aminoacylase 1 subfamily, includes Bacillus subtilis YhaA and Staphylococcus aureus amidohydrolase, SACOL0085. Peptidase M20 family, uncharacterized subfamily of bacterial proteins predicted as putative amidohydrolases or hippurate hydrolases. These are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine). This family includes Staphylococcus aureus amidohydrolase, SACOL0085, which contains two manganese ions in the active site, and forms a homotetramer with variations in interdomain orientation which possibly plays a role in the regulation of catalytic activity.	0
NZ_CP012712.1\|WP_003247704.1\|389167_390127_-\|sporulation-protein	gnl\|CDD\|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	3.49085e-67
NZ_CP012712.1\|WP_042384779.1\|380713_381790_+\|dipeptide-epimerase	gnl\|CDD\|239435	cd03319, L-Ala-DL-Glu_epimerase, L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of the murein peptide of peptidoglycan, of which L-Ala-D-Glu is a component. L-Ala-D/L-Glu epimerase is a member of the enolase-superfamily, which is characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	3.32849e-132

>NZ_CP012712.1|WP_148259566.1|388517_388754_-|hypothetical-protein
MRIGKERNQQELDHHINRSGARVFEAVANKTYDRQEIRAIAEKMIAGLLVDMPVAVLATRNFSALKRRDRRFAYGWEY
>NZ_CP012712.1|WP_013876128.1|387240_388542_-|transcriptional-regulator
MRIRLGILGADDSLAIIQNVTNEYKELHCIPVIYWDEEEIIDFIRPYMHQVDMWLFSGQVPYSIVKEWGEIDCPMFYVPHTGASLYRTLLRIYYERQIPVQQLSFDTYHPSEIERLLEEVGIGERVPYVKHYQGGISAAALAQYHYGLWKQGLTKAAVTCLRTAQLELEKLGVPVYRVLPARSAVESVVQMIIRTGEMLRFQDAQIAVQMMEVDSLFAISNETFSTDEIYKMEMKVTEKLLKYAKKIQGSLKIAGPGRYVIFTTRGALKDITDHYKIIPTIKELEDMDREIAACGIGVGRTAYEAEIHAGKAFLHAKKYGRGTWMVVFDDDTIAGPLGRAEQIRYSFDCAELQAISQKTNLSVATLSKISAILRKLGKNEMNAYELAAYMQILPRSARRILHELEMKGLAEVVGETNPYPRGRPRKVYRIFLG
>NZ_CP012712.1|WP_042384785.1|385868_387098_-|Zn-dependent-hydrolase
MINGDRLWNRLLELGTIGKQPSGGITRLSFTKEERAAKEKVASYMKEAGLAVYEDAVGNLIGRKEGKEKDAPAVLVGSHIDSVYNGGMFDGPLGVLAAVEVLQTMNERGVKTKHPIEVVAFTDEEGARFSYGMIGSRGMAGTLSEEELVHQDKYGISLAAAMEEAGLDPGKIGKAARRKGSVKAYVELHIEQGRVLEQANLPVGIVTGIAGLIWAKLTVKGKAEHAGATPMPIRRDPLVAAAQIIQVIEQEAKKTGTTVGTVGQMQVFPGGINIIPERVEFSLDLRDLDAAVRDSVFLSIIERAKQIGNERNVDVAVELLQKMPPVLCSELVQNAAKEACRQLGFDVFTLPSGASHDGVQLAGLCPIGMIFVRSKDGVSHSPEEWSSKEDCAAGANVLYHTVLSLAMTA
>NZ_CP012712.1|WP_003247709.1|384659_385844_-|amidohydrolase
MTNEEIKRLVDEVKEEVIAWRRHLHANPELSFQEEKTAQFVYETLQSFGNLEISRPTKTSVMARLIGPQPGRVVAIRADMDALPIQEENTFAFASKNPGVMHACGHDGHTAMLLGTAKILSQLRDQIKGEIRFLFQHAEELHPGGAEEMVQAGVMDGVDVVIGTHLWSPLERGKIGIVYGPMMAAPDRFFIRIHGKGGHAALPHQTIDAIAVGAQVVTNLQYIVSRNVDPLEPLVVSVTQFVAGTTHNVIPGSVEIQGTVRSFDETLRKSVPKLMERIIKGITEAHGATYEFEFEYGYRPVINNNEVTRVIEETVREVFGEEAVDHIKPNMGGEDFSAFQQKAPGSFFYVGAGNKEKGIVYPHHHPRFTIDEDALEIGVRLFVHAAFKLLAEAS
>NZ_CP012712.1|WP_003247710.1|384407_384608_-|DUF3311-domain-containing-protein
MKGIRWLMVLPFLGILGGIPFANKVTPYVLGMPFILFWLVAWVIMTSIIMAVVYRFDPDVREEERT
>NZ_CP012712.1|WP_003247712.1|382938_384411_-|sodium:solute-symporter
MNAALVIIFAFLLFSLYLGVQARKGKDMNLEQWTVGGRGFGTIFVFLLMAGEIYTTFTFLGGSGWAYGKGGPTFYIIAYGCLAYVLSYWMLPKVWKYAKEHKLMSQSDFFVSKYNSPLLGVLVSLVGVIALIPYLVLQLKGLGIIVSEASYGTISSTAAIWIGVLAVTVYVTISGIHGSAWTAVVKDIMILVVAIFLGLYLPFHYYGGIQPMFEAIEQAKPGFLALPDKGMSVSWFISTVLLTVLGFYMWPHTFGSIYSAKSANVFRKNAMILPIYQLVLLFVFFVGFAAILQIPHLEGSDADLALLRLSIQTFDPWVVGLIGAAGLLTAMVPGSMILMTASTLLAKNVYKVFSPSATDEQVAKLAKYLVPVIAFISLYFTFRGGNTIVALLLMGYSLVTQLFPSFVLSLMKNNFVTKQGAFAGIIAGVATVAYITLSGSSIGTLFPSLPQAVQDLNVGIIALIVNIVVTVVVSWIPTRSASFDTEKSAM
>NZ_CP012712.1|WP_042384782.1|381811_382819_+|C40-family-peptidase
MKKWKWYLTAFLCFCMVFGFLLPANAKTDNDEAAYVDVSVATLWTEPNIARDIDSPSLSNPVDMWKWTKSMTYEEKLWLVGNLETQALYGMKVTILEKRGDWAKVVVHGQPTPRHPLGYPGWMPIRQLTKGKVFAPFQAKPFAQVTSPTAWLYKDPKGNHKFMEISFNTRLPVVHSTKNAVKVMTPSDGAKWLKKEDVQIFRTEADIPSPTGEDLVNTAKQFLGLPYLWAGTSGFGFDCSGFTHTIYKAHGITIPRDSSVQAQFGIPVPESELQPGDLLFFAYNNGKGRIHHVGMYIGNGKMIHSPNSSTTVRIDDYRAPGYGEEFAGARRYIQK
>NZ_CP012712.1|WP_042384779.1|380713_381790_+|dipeptide-epimerase
MKIKDATIAVQSTPLIKPFKTALRTATQIESIVVKITLDNGMEGYGAAVPTEAITGETKQGIIGILENVLIPKIIGREIEEINKNDKDIQTSCIGNTSAKAALEMAMYDALCKLLNIPLYQLFGGKMNHHVNDMTISVNNVEEMVNDAKKVTEKGFSILKIKVGKEAEKDIERIERIYDEVGPNISLRIDANQGWTAKDAVKIIQSLEQLHLPIEFIEQPVSKHDIKGLQFIRERVNVPIMADESVFSARDALELIRHHAVDLINIKLMKTGGLREAYKIASLAEAAGIECMIGSMMEPTLSVLAAAHLAMAHPNITKVDLDAPLWINDDSSRSFFQESKINVPYLPGIGYVPSMPNH
>NZ_CP012712.1|WP_003247717.1|379531_380695_+|DUF819-domain-containing-protein
MIQDGVVYLSILLAYVALIAFAEQKSKSKLFKVVPGIIFIYVGGALMQTFGVFGKTNSIDNTYNTVRNVLLPAMLILMLLHCDLRKIIKMGPKILLTFFAASFTIIIGFTVTYLLLKEFYAKDTWKAFAALSSSWTGGSANMVILQKILDVPENIFGYALIMDTVNYSIWVMFMFWLVPFADRFNRWTKAKAIEVPVAADEVATTTENHQGKMGFTELIVLLGFSILLSTICTEIGNALPELGAVFNGTTWTIVFASVIGLLLAMTKAAKIPGANDVSKVMLYVIIALIASKADFSQLFQAPIYIISGFLILLIHALLMLIIAKVCKLDLFTMGVTSLANIGGVASTPILAGAYHQSLIPVGILTALLGNLLGTYYGLLTARILSSL
>NZ_CP012712.1|WP_003247718.1|379104_379452_+|DUF3870-domain-containing-protein
MFENNTVYIIGDAKAPSNNPITQQYKAFFIGLVVNKENSMIVDADCSATIELTKSFVKSLLVGRSILDIDTVTKEIQTRYFGSSQKAFIVAFKNASLKYQNIVSSAASSVLSSRR
>NZ_CP012712.1|WP_003247704.1|389167_390127_-|sporulation-protein
MWKKLLSKLGVGAAKVDLVLHHPRVRVGEQLKGEFLIEGGTVEQHIRKLEVELQLMVQADGKAYRRTVAVIPVSSSFTIQPGERKALPFSYVLPLHLPITRPRVRYAFVTRLDIADGVDAFDQDAIDILPPLPLEKLFHALGNIGFREKPSSGKITAYGQEFAFFPTKEWMGVVEEVEFSAQIEENGIRLYLEVDVRSGFGGFHETELKREIFFSNEEIENVEEMSGKLRAVIGEMIQQPRSYVGPSHVPYSSYPSQHVSHHHGGHGMMGAIGGFAAGMLAGMVAEELLEDVVEDALDDGIEDVMDDIGDWFDGGDDIL
>NZ_CP012712.1|WP_003247702.1|390236_390896_-|sporulation-membrane-protein-YtaF
MWKYISMIMLAFVVSMDSLSVGVTYGIRKIQFPLRSKLVIACMSGAMLLLSMCVGSVFLLFLPGQAERWLASAILIALGIWAIYNVVKKETDKEEKMEPLAPPPRIKAWRFQLKRFGIVVQVLKCPAMGDLDSSGSISMKEAMLIGFALSMDAFGAGISASFLKYPPLLLALLVCTLNIIFIGLGLKAGNLLSKIKAVRKVTVIPGTILICLGIMKIFF
>NZ_CP012712.1|WP_003247700.1|391005_392841_-|APC-family-permease
MASLKRLLIGSPMETKRLQHEKLPKWKALAVFSSDALSSVAYATEEILLVLMLLGTSVFFYSLPIAVAILVLLLLVTLSYRQIIYAFPSGGGAYVVARDHLNTTTSLVAGAALMIDYVLTVAVSISSGVAALTSAFPGLLPWKVEIAVALVLLLMILNLRGITESATVFAYPTYLFIISVLVLIVAGGWQLWHEGWHGFNYKEHASAAHFFASGYSMFILLRAFASGCSAMTGIEAISNGVPAFKPDSSKNAAITMGWMSLLLGTMFLGITVLAAGFGVTPVEHKTVISQIGHHVFGNSIFFYLFQMITMFILVLAANTSFAGFPQLASIIANDRFLPRSLSARGDRLVFSNGIILLSILAIVLIVAFHGETHSLIPLYAVGVFLSFTIGQSGLLKKIWKEKEKRNITTLVIVMTGMTVTGLVTVITVVAKFTQGAWLVIVAIPSLVWLFYRIHDHYVKLGEQLKLDEQEWTRREKMLKPKVIIPISGVSKVVAQSVQYARSISNDITAVSVIFYEEEEQKLRAKWEKFYPDIPLRVIYSPYRTILSPILDYINEVEKQANSSPITILMPQFVVKKWWHALLHNQTAVVLRFFLIMKKDIVIATLPYHLKE
>NZ_CP012712.1|WP_003247699.1|393271_394612_-|TrkH-family-potassium-uptake-protein
MKKARKYYLDPPKVLVAGFAVIILVGTALLMLPIATNDGKGLPFLDALFTATSATCVTGLVVVDTGTAFTLFGQLVILALIQVGGLGFMTFATLFAFLLGKRISLKERLLLQEAMNNLTIEGIVRLVKRVLIFTVVIELIGGLLLAVRFSFDMPLLKAFYFGMFHAVSNFNNAGFDLMGNFRSLTGYVEDPVVTLVICALITLGGIGFIVMNEVYEYRQTRRFSLHTKVAVATSGILLASSILLIFLLEFHNPNTLEPLSPLGKFLATLYQAVTPRTAGSNTLNISDLTQPTLFLIIFLMFVGASPGSTGGGIKTTTFAILLGAVWSQIRGKEDVVFFKKRIMYDTIYKSLTVTISGLFIVIFVTMLLTITEQGKDFLMILFEATSAFSTVGLSMGLTPELSPFGKVIIMCTMFAGRVGPLTIAYAVTLHRKPDPFRYPKGKIMIG
>NZ_CP012712.1|WP_003247697.1|395075_397037_+|LTA-synthase-family-protein
MKRIGGKLLEKYRSLPDQYISFFIFAIFLFWMKTYAAYQAEFHLGISNSMQEFLLFINPVSSAVFFFGLALLAKGKRTYTWLIIINFVLSFILYANIVYYRFFSDFITLPTLTQTKNFGDLGSSIWELIKWYDIFYFLDTVILIAIVTSKRFSLPAVQVGRYKKSIVFAIAALIFSVNLALAEMDRPQLLTRTFDRNYIVKYLGVYNYLIYDAVQSMKSSTQRAFANKSDITTVLNHVQATYAKPNPQYFGVAKGMNVIYIHLESFQNFLINYKLHGQEVTPFLNSLVRDPNTFYFDNFFHQTGQGKTSDAEFMLENSLFGLPQGAVFTTKGQNTYHAAPALLHQHGYTTAVFHGNYKTFWNRDEIYKSFGFDHFFDASYYDMSDENVLNYGLKDKPFFRESIPLLESLREPFYVKFITLSNHFPYPISEEDATIEPANTGDGSVDRYFQTARYLDESLKEFFDYLKKSGLYDRSVIILYGDHYGISENHNKAMSQVLGKEITPFEHAQLQRVPLFIRVPGVKGGIMHQYGGQIDLLPTVLHLLGIDTKNYVHFGTDLLSPEHQEIVPFRNGDFVTPTVTAVNGKYYDSKTGEPIPETPEVKQLEQIVRTKLDLSDKVVYGDLLRFYTPKGFKPVDPTKYDYNNRDEEKKGSK
>NZ_CP012712.1|WP_003247695.1|397050_398376_-|S8-family-peptidase
MFEYSIVQLARHYAHKLDRPLRHFLVSIYKPFLYTPCIIHKQLERWMKKMKRIPVIIQFHEENGVFALKEVEKQHFRMKIHHQFRYIPSCSAEVTPQALEQILQRHDVKKVYLNRKVSALLNNAVPSANAKNVAVNGTALSGKGVTIAIVDTGIYPHPDLEGRIAGFVDFVNGRTEPYDDNGHGTHCAGDAAGNGSVSSGLYRGPAYEANVVGVKVLNKVGAGRLDTIIRGIEWCIQYNETSKDEKIDIISLSLGGESQPFPEENDDPLVQAAEKAWDKGIVVCAAAGNAGPEYRTISSPGISDKIITVGALDDRDTAETREDDEIADFSSRGPTYYGVSKPDIVVPGVNIVSLRAPKSFLDKYQKQNRIGQYYMSMSGTSMATPICAGIVALMLQYKPDATPDEIKRALKEGAGLWKDRDPNIYGAGYVDAQRAIGLLAK
>NZ_CP012712.1|WP_003247693.1|398939_399650_-|DsbA-family-oxidoreductase
MKIEVWSDFVCPFCYIGKRRLEKALEQFPHKDQVEVVFRSFELDPDAKKHYDMSIHEIIAKKYGISVEEAKRVNADIGRQAESVGLTFRFDTMKPTNTFDAHRLAKYAEERGKLPEVAERLFQAYFTDSQQISDHNVLIDLAGEAGLDREEARQVLESSRYGDEVRKDEAEAARLGVRGVPFFVLNRKYAISGAQPIEVFMQALEKVWEEEKTTSPLQPLSSDGGGQCTDGSCQVQ
>NZ_CP012712.1|WP_003247692.1|399791_400484_-|DUF1129-family-protein
MNAKDLVALNNEKRKQLNEHNRNYYENMLVYIRSQLLLSEQQSEELLMELLDHLLEAQKHGKMAEDIFGTDAKAYCDELIRQLPKEKKRNIYAFIGYLAVRLFALGVLVTGAVELVAEWFTDVDDTVYLGKASVLFVIDFAVILLAVALVMRWIRKSAFHDDSSTFGGKVKEFLGIWFACCLVIGMFVLAKKLVPEFGYRIEAGGMVRILFGLFVFAVTWQLNKKFRITK
>NZ_CP012712.1|WP_003247691.1|400480_400813_-|PadR-family-transcriptional-regulator
MSLRSQLLKGVLEGCILAIIKKESVYGYELSVKLQKFGLNDVSEGSIYPLLLRLQKAGLIKGEMRDSPSGPKRKYYHLTEKGEEALQDFIAEWESIRKPVEKILRGGNME
>NZ_CP012712.1|WP_042384790.1|401364_402591_-|threonine-synthase
MPFSYVSHLYCPKCQKTYGTNKKHQLCECGSPLLVAYHLDALRADLSREIIASREPNLWRYHELLPVENPEHIVSLGEGMTPLVPMPRLGKDMDIEQLYMKDEGVIPTGTFKARGAAVGISKAKELGVKKLAMPTNGNAGAAWSLYAARAGIQVTVVMPVDAPTITRNECAIAGADLYLVNGLISDAGAIVSKAIQERNLYDASTLKEPYRIEGKKTMGLEIAEQFSWQLPDVILYPTGGGVGLIGIYKVLKELQDLGWVQGKMPRLVAVQAQNCAPIVKAWNERKRVSEFWPNSSTVAFGINVPKALGDFLVLDALYKTDGCAIAVEDDAIINEQRNVANLEGAFICPEGAAAFVAARRLRERGWIRRGERVVVLNTGIGLKYTHTVSIEVPILQPGDHLPERKDYS

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Crispr_ID: NZ_CP012712_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012712_4

1052869-1054869

TypeI-B

Consensus_repeat	Method
GTTTGTATCTTACCTATGAGGAATTGAAA	PILER-CR
GTTTGTATCTTACCTATGAGGAATTGAAAC	CRISPRCasFinder
GTTTGTATCTTACCTATGAGGAATTGAAAC	CRT

29 spacers

cas6,cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1

The CRISPR arrays of NZ_CP012712_4

>merge|NZ_CP012712|4|1052869-1054869|PILER-CR,CRISPRCasFinder,CRT
GTTTGTATCTTACCTATGAGGAATTGAAACTGCTGATAATGCGTTAATTATTGACACGAAAAAATCTGTTTGTATCTTACCTATGAGGAATTGAAACATCGCGGCCGTAGATGATGTGTACGGAACGTTTCACGTTTGTATCTTACCTATGAGGAATTGAAACGCAACGATGAACTCTAATGTATCGTCGTTGCTGTCTCGTTTGTATCTTACCTATGAGGAATTGAAACCATTTTCCGCTTGGTGAAGCACTAGAAGAGATGCGCACGTTTGTATCTTACCTATGAGGAATTGAAACACTTGGTTGAAAAACCTACTGATGAAAAGATACGAAAGTTTGTATCTTACCTATGAGGAATTGAAACTGTTTTCTTGAGGTTTTTCTAATGTTAACTGTAAAATGTTTGTATCTTACCTATGAGGAATTGAAACTCAGTTGTTTCCTGCTGTTTTTCTTGTGTATCCCCCGTTTGTATCTTACCTATGAGGAATTGAAACCCACGATGTCATGACATTGTATAGACGTTCCAGATAGTTTGTATCTTACCTATGAGGAATTGAAACTGTTTTTTCGGATAAGGATTTTGAGAGAGTATTAGAGTTTGTATCTTACCTATGAGGAATTGAAACCTAATCTCGAACCAGTCCATAAAATAGTCATCGATCTCGTTTGTATCTTACCTATGAGGAATTGAAACCGGCTATCAAGCGAGAAATAAGCCTCATCGACAATCAGTTTGTATCTTACCTATGAGGAATTGAAACAGGATTGGAGAACATGCTGACCAACATGTTCGTCCAGTTTGTATCTTACCTATGAGGAATTGAAACCTGTAGGTATGCGTTGTTCAACATAAGTAGGGAAAGGTTTGTATCTTACCTATGAGGAATTGAAACAGTCAACAGTTTCAAGTAATTCTGTTTGCTTTCCAGGTTTGTATCTTACCTATGAGGAATTGAAACTCAGAACTAGCGTAGAGGATAGAACAGGTAGCTATCGCCGTTTGTATCTTACCTATGAGGAATTGAAACACGCACCTAGATCACTTATTACCTTATCTGAACTTCGATGTTTGTATCTTACCTATGAGGAATTGAAACTGAAAAGTATATAAAGCATTTTAATATTGGAGGCGATTGTTTGTATCTTACCTATGAGGAATTGAAACTCCGAACGATAGCTTTCCGACACTTTGCCGATGGCACGTTTGTATCTTACCTATGAGGAATTGAAACTCCCGCAGGAAACATCTCCTTTGATGAGAGTTTAAAGTTTGTATCTTACCTATGAGGAATTGAAACAAGGAATATTCGTTCGAATCGTTTTTGCCGCGTGAGTTTATATCTTACCTATGAGGAATTGAAACTGGTAATATGAAAGTATGGGTAGATCAAGATTAGAGTTTGTATCTTACCTATGAGGAATTGAAACAACAATGCGGAAGTGATTCCGATTCCGACGCGTCCTGGTTTGTATCTTACCTATGAGGAATTGAAACACCGATAACGGTGGAAGTGCTGTTTCAACTATCGCAGAGTTTGTATCTTACCTATGAGGAATTGAAACTCCTTCCTCATAAAACCCTATACCGAAACGTATGGACGGGTTTGTATCTTACCTATGAGGAATTGAAACTATCTTTGAGCATGCTTTTCACTTCCCGTTTGTCCGCTGTTTGTATCTTACCTATGAGGAATTGAAATCTTTTTCATTCATGAGTATTCCCCCTTCTTTGTTTAGTTTGTATCTTACCTATGAGGAATTGAAATTCAGCCGCCCCGTATCCATATGCTCGTACCATTGGATTCGTTTGTATCTTACCTATGAGGAATTGAAATTTGTGCGAATCATAAAAAACCCCACTCGTCCGAGTAGTTTGTATCTTACCTATGAGGAATTGAAACGTGGTCTGCGATTTGACAGCTTTCGTGTCGCGTGCCTGTTTTATATCTTATGGACCGATTTTGCCTGTTTTTATCTTAGCTACGAAGATTGTCCCC

>NZ_CP012712|4|3|1052869-1054772|PILER-CR
GTTTGTATCTTACCTATGAGGAATTGAAA	CTGCTGATAATGCGTTAATTATTGACACGAAAAAATCT
GTTTGTATCTTACCTATGAGGAATTGAAA	CATCGCGGCCGTAGATGATGTGTACGGAACGTTTCAC
GTTTGTATCTTACCTATGAGGAATTGAAA	CGCAACGATGAACTCTAATGTATCGTCGTTGCTGTCTC
GTTTGTATCTTACCTATGAGGAATTGAAA	CCATTTTCCGCTTGGTGAAGCACTAGAAGAGATGCGCAC
GTTTGTATCTTACCTATGAGGAATTGAAA	CACTTGGTTGAAAAACCTACTGATGAAAAGATACGAAA
GTTTGTATCTTACCTATGAGGAATTGAAA	CTGTTTTCTTGAGGTTTTTCTAATGTTAACTGTAAAAT
GTTTGTATCTTACCTATGAGGAATTGAAA	CTCAGTTGTTTCCTGCTGTTTTTCTTGTGTATCCCCC
GTTTGTATCTTACCTATGAGGAATTGAAA	CCCACGATGTCATGACATTGTATAGACGTTCCAGATA
GTTTGTATCTTACCTATGAGGAATTGAAA	CTGTTTTTTCGGATAAGGATTTTGAGAGAGTATTAGA
GTTTGTATCTTACCTATGAGGAATTGAAA	CCTAATCTCGAACCAGTCCATAAAATAGTCATCGATCTC
GTTTGTATCTTACCTATGAGGAATTGAAA	CCGGCTATCAAGCGAGAAATAAGCCTCATCGACAATCA
GTTTGTATCTTACCTATGAGGAATTGAAA	CAGGATTGGAGAACATGCTGACCAACATGTTCGTCCA
GTTTGTATCTTACCTATGAGGAATTGAAA	CCTGTAGGTATGCGTTGTTCAACATAAGTAGGGAAAG
GTTTGTATCTTACCTATGAGGAATTGAAA	CAGTCAACAGTTTCAAGTAATTCTGTTTGCTTTCCAG
GTTTGTATCTTACCTATGAGGAATTGAAA	CTCAGAACTAGCGTAGAGGATAGAACAGGTAGCTATCGCC
GTTTGTATCTTACCTATGAGGAATTGAAA	CACGCACCTAGATCACTTATTACCTTATCTGAACTTCGAT
GTTTGTATCTTACCTATGAGGAATTGAAA	CTGAAAAGTATATAAAGCATTTTAATATTGGAGGCGATT
GTTTGTATCTTACCTATGAGGAATTGAAA	CTCCGAACGATAGCTTTCCGACACTTTGCCGATGGCAC
GTTTGTATCTTACCTATGAGGAATTGAAA	CTCCCGCAGGAAACATCTCCTTTGATGAGAGTTTAAA
GTTTGTATCTTACCTATGAGGAATTGAAA	CAAGGAATATTCGTTCGAATCGTTTTTGCCGCGTGA
GTTTATATCTTACCTATGAGGAATTGAAA	CTGGTAATATGAAAGTATGGGTAGATCAAGATTAGA
GTTTGTATCTTACCTATGAGGAATTGAAA	CAACAATGCGGAAGTGATTCCGATTCCGACGCGTCCTG
GTTTGTATCTTACCTATGAGGAATTGAAA	CACCGATAACGGTGGAAGTGCTGTTTCAACTATCGCAGA
GTTTGTATCTTACCTATGAGGAATTGAAA	CTCCTTCCTCATAAAACCCTATACCGAAACGTATGGACGG
GTTTGTATCTTACCTATGAGGAATTGAAA	CTATCTTTGAGCATGCTTTTCACTTCCCGTTTGTCCGCT
GTTTGTATCTTACCTATGAGGAATTGAAA	TCTTTTTCATTCATGAGTATTCCCCCTTCTTTGTTTA
GTTTGTATCTTACCTATGAGGAATTGAAA	TTCAGCCGCCCCGTATCCATATGCTCGTACCATTGGATTC
GTTTGTATCTTACCTATGAGGAATTGAAA	TTTGTGCGAATCATAAAAAACCCCACTCGTCCGAGTA
GTTTGTATCTTACCTATGAGGAATTGAAA

>NZ_CP012712|4|4|1052869-1054773|CRISPRCasFinder
GTTTGTATCTTACCTATGAGGAATTGAAAC	TGCTGATAATGCGTTAATTATTGACACGAAAAAATCT
GTTTGTATCTTACCTATGAGGAATTGAAAC	ATCGCGGCCGTAGATGATGTGTACGGAACGTTTCAC
GTTTGTATCTTACCTATGAGGAATTGAAAC	GCAACGATGAACTCTAATGTATCGTCGTTGCTGTCTC
GTTTGTATCTTACCTATGAGGAATTGAAAC	CATTTTCCGCTTGGTGAAGCACTAGAAGAGATGCGCAC
GTTTGTATCTTACCTATGAGGAATTGAAAC	ACTTGGTTGAAAAACCTACTGATGAAAAGATACGAAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TGTTTTCTTGAGGTTTTTCTAATGTTAACTGTAAAAT
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCAGTTGTTTCCTGCTGTTTTTCTTGTGTATCCCCC
GTTTGTATCTTACCTATGAGGAATTGAAAC	CCACGATGTCATGACATTGTATAGACGTTCCAGATA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TGTTTTTTCGGATAAGGATTTTGAGAGAGTATTAGA
GTTTGTATCTTACCTATGAGGAATTGAAAC	CTAATCTCGAACCAGTCCATAAAATAGTCATCGATCTC
GTTTGTATCTTACCTATGAGGAATTGAAAC	CGGCTATCAAGCGAGAAATAAGCCTCATCGACAATCA
GTTTGTATCTTACCTATGAGGAATTGAAAC	AGGATTGGAGAACATGCTGACCAACATGTTCGTCCA
GTTTGTATCTTACCTATGAGGAATTGAAAC	CTGTAGGTATGCGTTGTTCAACATAAGTAGGGAAAG
GTTTGTATCTTACCTATGAGGAATTGAAAC	AGTCAACAGTTTCAAGTAATTCTGTTTGCTTTCCAG
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCAGAACTAGCGTAGAGGATAGAACAGGTAGCTATCGCC
GTTTGTATCTTACCTATGAGGAATTGAAAC	ACGCACCTAGATCACTTATTACCTTATCTGAACTTCGAT
GTTTGTATCTTACCTATGAGGAATTGAAAC	TGAAAAGTATATAAAGCATTTTAATATTGGAGGCGATT
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCCGAACGATAGCTTTCCGACACTTTGCCGATGGCAC
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCCCGCAGGAAACATCTCCTTTGATGAGAGTTTAAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	AAGGAATATTCGTTCGAATCGTTTTTGCCGCGTGA
GTTTATATCTTACCTATGAGGAATTGAAAC	TGGTAATATGAAAGTATGGGTAGATCAAGATTAGA
GTTTGTATCTTACCTATGAGGAATTGAAAC	AACAATGCGGAAGTGATTCCGATTCCGACGCGTCCTG
GTTTGTATCTTACCTATGAGGAATTGAAAC	ACCGATAACGGTGGAAGTGCTGTTTCAACTATCGCAGA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCCTTCCTCATAAAACCCTATACCGAAACGTATGGACGG
GTTTGTATCTTACCTATGAGGAATTGAAAC	TATCTTTGAGCATGCTTTTCACTTCCCGTTTGTCCGCT
GTTTGTATCTTACCTATGAGGAATTGAAAT	CTTTTTCATTCATGAGTATTCCCCCTTCTTTGTTTA
GTTTGTATCTTACCTATGAGGAATTGAAAT	TCAGCCGCCCCGTATCCATATGCTCGTACCATTGGATTC
GTTTGTATCTTACCTATGAGGAATTGAAAT	TTGTGCGAATCATAAAAAACCCCACTCGTCCGAGTA
GTTTGTATCTTACCTATGAGGAATTGAAAC

>NZ_CP012712|4|3|1052869-1054869|CRT
GTTTGTATCTTACCTATGAGGAATTGAAAC	TGCTGATAATGCGTTAATTATTGACACGAAAAAATCT
GTTTGTATCTTACCTATGAGGAATTGAAAC	ATCGCGGCCGTAGATGATGTGTACGGAACGTTTCAC
GTTTGTATCTTACCTATGAGGAATTGAAAC	GCAACGATGAACTCTAATGTATCGTCGTTGCTGTCTC
GTTTGTATCTTACCTATGAGGAATTGAAAC	CATTTTCCGCTTGGTGAAGCACTAGAAGAGATGCGCAC
GTTTGTATCTTACCTATGAGGAATTGAAAC	ACTTGGTTGAAAAACCTACTGATGAAAAGATACGAAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TGTTTTCTTGAGGTTTTTCTAATGTTAACTGTAAAAT
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCAGTTGTTTCCTGCTGTTTTTCTTGTGTATCCCCC
GTTTGTATCTTACCTATGAGGAATTGAAAC	CCACGATGTCATGACATTGTATAGACGTTCCAGATA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TGTTTTTTCGGATAAGGATTTTGAGAGAGTATTAGA
GTTTGTATCTTACCTATGAGGAATTGAAAC	CTAATCTCGAACCAGTCCATAAAATAGTCATCGATCTC
GTTTGTATCTTACCTATGAGGAATTGAAAC	CGGCTATCAAGCGAGAAATAAGCCTCATCGACAATCA
GTTTGTATCTTACCTATGAGGAATTGAAAC	AGGATTGGAGAACATGCTGACCAACATGTTCGTCCA
GTTTGTATCTTACCTATGAGGAATTGAAAC	CTGTAGGTATGCGTTGTTCAACATAAGTAGGGAAAG
GTTTGTATCTTACCTATGAGGAATTGAAAC	AGTCAACAGTTTCAAGTAATTCTGTTTGCTTTCCAG
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCAGAACTAGCGTAGAGGATAGAACAGGTAGCTATCGCC
GTTTGTATCTTACCTATGAGGAATTGAAAC	ACGCACCTAGATCACTTATTACCTTATCTGAACTTCGAT
GTTTGTATCTTACCTATGAGGAATTGAAAC	TGAAAAGTATATAAAGCATTTTAATATTGGAGGCGATT
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCCGAACGATAGCTTTCCGACACTTTGCCGATGGCAC
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCCCGCAGGAAACATCTCCTTTGATGAGAGTTTAAA
GTTTGTATCTTACCTATGAGGAATTGAAAC	AAGGAATATTCGTTCGAATCGTTTTTGCCGCGTGA
GTTTATATCTTACCTATGAGGAATTGAAAC	TGGTAATATGAAAGTATGGGTAGATCAAGATTAGA
GTTTGTATCTTACCTATGAGGAATTGAAAC	AACAATGCGGAAGTGATTCCGATTCCGACGCGTCCTG
GTTTGTATCTTACCTATGAGGAATTGAAAC	ACCGATAACGGTGGAAGTGCTGTTTCAACTATCGCAGA
GTTTGTATCTTACCTATGAGGAATTGAAAC	TCCTTCCTCATAAAACCCTATACCGAAACGTATGGACGG
GTTTGTATCTTACCTATGAGGAATTGAAAC	TATCTTTGAGCATGCTTTTCACTTCCCGTTTGTCCGCT
GTTTGTATCTTACCTATGAGGAATTGAAAT	CTTTTTCATTCATGAGTATTCCCCCTTCTTTGTTTA
GTTTGTATCTTACCTATGAGGAATTGAAAT	TCAGCCGCCCCGTATCCATATGCTCGTACCATTGGATTC
GTTTGTATCTTACCTATGAGGAATTGAAAT	TTGTGCGAATCATAAAAAACCCCACTCGTCCGAGTA
GTTTGTATCTTACCTATGAGGAATTGAAAC	GTGGTCTGCGATTTGACAGCTTTCGTGTCGCGTGCCTGTTTTATATCTTATGGACCGATTTTGCCT
GTTTTTATCTTAGCTACGAAGATTGTCCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012712.1\|WP_013877553.1\|1040086_1041364_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340874
NZ_CP012712.1\|WP_013877550.1\|1049884_1050382_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP012712.1\|WP_042383926.1\|1055082_1055982_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381364
NZ_CP012712.1\|WP_042383925.1\|1059696_1060764_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224428
NZ_CP012712.1\|WP_003253142.1\|1060813_1061587_+\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132844
NZ_CP012712.1\|WP_042383938.1\|1043540_1045511_+\|TIGR02556-family-CRISPR-associated-protein	cas8b1	pfam09484_cas8b1_CAS-I-B	gnl\|CDD\|187861
NZ_CP012712.1\|WP_042383931.1\|1050384_1051392_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NZ_CP012712.1\|WP_042383933.1\|1047401_1049885_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NZ_CP012712.1\|WP_042383929.1\|1051939_1052686_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NZ_CP012712.1\|WP_003253145.1\|1059257_1059746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_003253159.1\|1051401_1051665_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP012712.1\|WP_035502873.1\|1057144_1059226_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|223964
NZ_CP012712.1\|WP_003253141.1\|1061946_1063020_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_CP012712.1\|WP_003253139.1\|1063009_1063801_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224097
NZ_CP012712.1\|WP_013401699.1\|1046623_1047358_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|187823
NZ_CP012712.1\|WP_013401694.1\|1056184_1056862_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|273017
NZ_CP012712.1\|WP_013401689.1\|1064614_1065688_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270381
NZ_CP012712.1\|WP_042383936.1\|1045673_1046609_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NZ_CP012712.1\|WP_003253168.1\|1042288_1043044_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP012712.1\|WP_003253137.1\|1063811_1064618_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224098

Protein	Function_ID	Function_description	E-value
NZ_CP012712.1\|WP_013877553.1\|1040086_1041364_+\|MFS-transporter	gnl\|CDD\|340874	cd17316, MFS_SV2_like, Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily. This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.52016e-32
NZ_CP012712.1\|WP_013877550.1\|1049884_1050382_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.04208e-69
NZ_CP012712.1\|WP_042383926.1\|1055082_1055982_+\|aldo/keto-reductase	gnl\|CDD\|381364	cd19138, AKR_YeaE, Escherichia coli YeaE and similar proteins. Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.	1.07907e-179
NZ_CP012712.1\|WP_042383925.1\|1059696_1060764_+\|hypothetical-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	1.13095e-06
NZ_CP012712.1\|WP_003253142.1\|1060813_1061587_+\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132844	cd07205, Pat_PNPLA6_PNPLA7_NTE1_like, Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1. Patatin-like phospholipase domain containing protein 6 (PNPLA6) and protein 7 (PNPLA7) are included in this family. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. PNPLA7 is an insulin-regulated phospholipase that is homologus to Neuropathy Target Esterase (NTE or PNPLA6) and is also known as NTE-related esterase (NRE). Human NRE is predominantly expressed in prostate, white adipose, and pancreatic tissue. NRE hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid, but shows no lipase activity with substrates like triacylglycerols (TG), cholesteryl esters, retinyl esters (RE), phosphatidylcholine (PC), or monoacylglycerol (MG). This family includes subfamily of PNPLA6 (NTE) and PNPLA7 (NRE)-like phospholipases.	6.66772e-66
NZ_CP012712.1\|WP_042383938.1\|1043540_1045511_+\|TIGR02556-family-CRISPR-associated-protein	gnl\|CDD\|187861	cd09730, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as TM1802 family.	7.31032e-82
NZ_CP012712.1\|WP_042383931.1\|1050384_1051392_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	1.77071e-168
NZ_CP012712.1\|WP_042383933.1\|1047401_1049885_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	4.35816e-47
NZ_CP012712.1\|WP_042383929.1\|1051939_1052686_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.95694e-26
NZ_CP012712.1\|WP_003253139.1\|1063009_1063801_+\|ABC-transporter-permease	gnl\|CDD\|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	4.88049e-78
NZ_CP012712.1\|WP_003253159.1\|1051401_1051665_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	6.70309e-30
NZ_CP012712.1\|WP_035502873.1\|1057144_1059226_+\|MMPL-family-transporter	gnl\|CDD\|223964	COG1033, COG1033, Predicted exporters of the RND superfamily [General function prediction only].	7.29995e-74
NZ_CP012712.1\|WP_003253141.1\|1061946_1063020_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	3.65673e-168
NZ_CP012712.1\|WP_003253137.1\|1063811_1064618_+\|ABC-transporter-permease	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	1.30318e-79
NZ_CP012712.1\|WP_013401699.1\|1046623_1047358_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|187823	cd09692, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	2.68143e-32
NZ_CP012712.1\|WP_013401694.1\|1056184_1056862_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|273017	TIGR00331, Heat-inducible_transcription_repressor_HrcA, heat shock gene repressor HrcA. HrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures. In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene. [Regulatory functions, DNA interactions].	2.06605e-05
NZ_CP012712.1\|WP_013401689.1\|1064614_1065688_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270381	cd13663, PBP2_PotD_PotF_like_2, The periplasmic substrate-binding component of an uncharacterized active transport system closely related to spermidine and putrescine transporters; contains the type 2 periplasmic binding fold. This group represents the periplasmic substrate-binding domain that serves as a primary polyamine receptor of an uncharacterized ABC-type transport system from gram-negative bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, as well as plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	8.78223e-154
NZ_CP012712.1\|WP_042383936.1\|1045673_1046609_+\|type-I-B-CRISPR-associated-protein-Cas7/Csh2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	3.54215e-72
NZ_CP012712.1\|WP_003253168.1\|1042288_1043044_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.7267e-87

>NZ_CP012712.1|WP_042383929.1|1051939_1052686_+|CRISPR-associated-endoribonuclease-Cas6
MRMIIQFRPKNGALILPINYEEVLQGFLYRSIQDFELAHFLHDVGYTKEKRRFKMFTFSRLYGTYRIHRHEKKIEFFDQVTWYISSALDSLIVNLAQNYLLREQFALNGQPIHIEETAVKRLEISEKRSYQIRMLSPLTVYSTYENQHGEKRTHFFSPFDAEFSKMVEKNFYNKFQAYFQQAPTEKVTISPIRVTKRDKVITVFKGFRINAWNGMYEIQAPLPYVKFMYDVGIGSKNSQGFGMFEFIK
>NZ_CP012712.1|WP_003253159.1|1051401_1051665_+|CRISPR-associated-endonuclease-Cas2
MFVILVYDFEKKRVAKALKIARKYLYWVQNSVFEGEISEANYVKLKMELENIMDPDVDSVVFYTFRTQKYSKREEMGLRKGGEENIL
>NZ_CP012712.1|WP_042383931.1|1050384_1051392_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKTLYIFQSGELSREDNSICFETTERKQKLPVEDVNDIYIFGEVNATKKFLELMAQKNICIHYFNHYGYYTGTFYPREHLNAGHVILKQAEAYLNPEKRLVLARKFIDGSIGQMIQVLKYYQNRVKTNNAKFKEMILDFQSSRAKLEQWTSVEEMMSTEGHVREKYYSMFDDILNHNPDFLFEKRSKRPPLNRLNAMISFGNQICYTMVLSEIYKTYLDPRIGFLHATNFRRFSLNLDVAEIFKPIMVDRLIFTLVNKKMITKKDFDKHMEGILLSEEGRKKFVGELDKRMKTTVNHRHLGKSVSYRRLIRLELYKIQKHLLGEKEYEPYRSLW
>NZ_CP012712.1|WP_013877550.1|1049884_1050382_+|CRISPR-associated-protein-Cas4
MDVNGTHIWYYFICKREVWLIAHQIAADQEDDNLEIGRFISETSYQRQKKELLIGNIKVDRIRREGDTLVVGEVKKSSTYEKSAYYQLLFYLDTLRKMGIEAKGELLFPKEKKVTKVEWTEEGKRVLEEAVADIRRIARLPVPPEPKKIGFCRSCAYREYCFAEE
>NZ_CP012712.1|WP_042383933.1|1047401_1049885_+|CRISPR-associated-helicase/endonuclease-Cas3
MYLSHNNPDKKLTVHLKEVYEYSQDMLKHVPLSDENRDMLEYISKIVAVAHDFGKYLSYFQDYLRTGETNGDLHHHSFISAVFAAHLLRHPANLNASWSEFAPLLGYFVVMHHHGNLRDISLDVTKSRHIAENTVQDSLYYRVNTLKQQIDDIKNHASAIVEDLSPLWDELSIPLSLSAELHSFLQNYEKAFDEVYRQYYLIDKRRKQELTRELYYYVLLLYSVLIDADKLSAANIERKPRVHIPAHLVDQYRETNFDVNVTEGTNGWRNRMYNVVMERIEELFKTKPEQRLFTLTAPTGAGKTLLSLSVALKWREQTERQHGYTPKIIYALPFTSVIDQNEKVIRDLLSQLDDFHANEQRYLVKHHHLSAFQYKTENEELPLRKALLLTESWEAELIVTTFVQLFHTLIGYENRALKKFHQIAGSIIILDEIQNVPMEYWPLLRSVLYKMAELFSCKILLLTATQPLIFPEGETVELLESEMVKPIDFFKEMERVELHWLGGDKGAYSPEEWMELFQNRFEDGKTYLAIFNTIKTSIEIYEGIKEWLKERGYDVIYLSTNIVPCERKRRIEQVRQLLKEKKKVVVISTQVVEAGVDVDFDVVYRDLGPIDSIVQAAGRCNRNGKLHELGKVYITPIEREGKLESQYVYKGVHTNIAKEVLPKTPVSEHQFFDIIMQYFTEVRGRKSFDASDGIISAMEELKFDAKDKSGSKNKPRYVSEFQLIENAHQAVDVFVEVDDQAMDIWQQYIQQVIEEKDFETRFENYLRLKKDVRQYVISAPIKLVKNLDRDLYEKTRMIHLSNDILNQYYNSEYGLIRTSEMVDAWIM
>NZ_CP012712.1|WP_013401699.1|1046623_1047358_+|type-I-B-CRISPR-associated-protein-Cas5
MKMLIFDLIGKMGHFRKIDTNSSSLSYAFPPRTTIVGMIAGILGMERDSYYEVFSPDQCQIAISVRTPIRKVMQTVNYMFVKSKAHLNNSGGHTQIPLEFVLPGGEEANLRYRIYFSHSDRSVYESVKERIQSGRYVYPPYLGLSELLGQLQWVAEAEGMLKESNDLVPIHSVVRIPDLRERSIQFSRDTRFLKEFMTRQFTNERMIQETDYYLFEQSRQLIAVPAVPYIAVAYGEAKENILWM
>NZ_CP012712.1|WP_042383936.1|1045673_1046609_+|type-I-B-CRISPR-associated-protein-Cas7/Csh2
MNNSDILFLYDAKLTNPNGDIDEENRPRMDYERSLNLVSDVRLKRYIRDYLEQIGHEIFVGKVDGETVNATERMKRLFEKYDGKVNINKLSKEQQNWMLDQFIDVRMFGATMPIKSEDKGSSMTFTGPIQFNWGYSLNKVTLVESASITSHFGSDDKNDGGNIGKDYRVYYSFLAFHGVISGHRAAHTRLTEEDIHLFDQAVVKAIPLSATRSKVGQYPRLYVRVEYHSPEFIAGDLRDLVHLEETEGLRSISEVTLHVDALVNKLLEVNVEIARIHYWQDSNLTLNYEGQKGLLADLLPSELADKLVSVL
>NZ_CP012712.1|WP_042383938.1|1043540_1045511_+|TIGR02556-family-CRISPR-associated-protein
MIKTIYTLGSKYLTEEKPSMIQAITLPIAKSDGATKYVVIVDFSIAEKKIRLTPKEIGASTSSELLWIGTADGAASPQWYGTVSNVEYLLSQTIPNLLERWDQKDFYYSLLKEARDVFFLDLGAAKKSDERYRYVFNPAYVSGELTETEGKKAVKEVAKQFQAFMEKEANVNIKDVLLYSLAINGQLVVSQPEYERLVIAEKLSVFEDAKKGVCALTNKEAFVTGETTKLKFNYYINDKISFASDLEKKSFVKNLSISKDAYQAIMAGEAYILRHFNTRFSGLPCYIIPDFLYDVPFANVPLQDISEHIHQFVRTVKTVETAEDLHREIEDYKEFDEQMDNHISLHFLFYTKAQSALKVNKLLSDVPLTHLRRLSFEMRKTGEIGQRFFGSEKFNLGLEPIYYLIPMRVQRGENFEKRKILQVYESLLTNKSLSYQWLITQFVQLAKVHMYANYNLYQYSSDKEEPNDFRLVNAMVRAQLFLKMLQNLNLIKEEREMTKVTYDLLDAHMVEYMETMNYNVAQSSLFLLGYLIAKIGAEQVRRTKARAEALGQAWGGKTVNKPILSKINYHGMNKQRLMLLSHEVFDKLRQLKIASLQNETVYIEHKRLFDLALQEKWNLSDRESVFYLLSGYAYGTKRILNSSKKDNSDPDFENEE
>NZ_CP012712.1|WP_003253168.1|1042288_1043044_+|DeoR/GlpR-transcriptional-regulator
MLAIERRQKIIEIIQKDKRALVSDLSKRFNVTEETIRRDLEKLEKEGIVTRTYGGAILNQHTNVDLPFATRKDINIPIKQEIAKKAINYIDERDSLFVDSSSTCFELVKLLENNRIVTVITNSAKILNEISSDSLHIISTGGTLRPYSSSLVGSIPQETVKKYNTDWAILSCKGIDMNRGIMDSNELDAELKKVMVQQASKTMMLVDHTKFDKVAFTSFLDFQQIDYLVTDKKPSDEWIKFLHEQNVTVIY
>NZ_CP012712.1|WP_013877553.1|1040086_1041364_+|MFS-transporter
MADGAKGGLKATITVAMSNYLEAGSIVAGAGGLSLWVEYLKLDDIKVGLLGAVSANGFGSAVGAFIGGILVDRFGRKFIYKYDLLVYMLGVLLITLSFNFPMLLLGYIITGLAVGAGIPAAWTYISEEAPANERAARVGWGQFAWSVGPVISLLLSVLLAPLGILGSRIIFAQLFVVAAITWIMQQQIRESMIWEEERQKQAELKAKYQISKSSTKELFTIKANLHAMILLIGIYCFWNLVAGVMGYFMPYIYEKVGGLTAAQANLLQAFLWILTVASTYFVFIKLGDKVNRRVLYGLGALMEIVAWIILSFAGMGKIQLMLFVILWGTAAGFGAQAFYALWAGELFHTKYRAKAQGFLFSVARIAVGLISLVVPTMITQLGFKFAGTVMIGFLLIAAIIGVAMAPETRGKTLKEIQQERYGTNY
>NZ_CP012712.1|WP_042383926.1|1055082_1055982_+|aldo/keto-reductase
MGVLDSKKIMEIRSRIEKRVVTLPDGTTVPCIGQGTWHMGEKPQEKAKEIKALQLGIELGMKVIDTAEMYGNGASERLVGEAIKGRRDDVFLVSKVYPHNAGLDKISTACENSLKRLGTDYLDLYLLHWRGRIPLEETIEGMEKLRKEGKILRWGVSNFDTDDMKELWNTTNGSNCATNQVLYHLGSRGIDFDLLPWHREHHVPIMAYSPLAQGGALRKQLLTDPIVNEIAKKYNVKPLQIALAWTIRTNDVIAIPKAGQEQHVLENAEAAAIELTQEDLKRLDEAFPKPRKKVPLDII
>NZ_CP012712.1|WP_013401694.1|1056184_1056862_+|helix-turn-helix-domain-containing-protein
MLLTERRKQFLQKLIDLYQKTNVPVHYETLAKALGVSKWTAYDMLKELEKLGYLTRDYTLNPGETGRSQIVFLPTAKATSLFEQERSEAINLEEWHKTKEKILEFLNSLKNCSLSAAVRKVLEEIPKAQIRVAFCAYIIGLFLVYLRKLGGKTEVLIKNLVQNAPTNEMRMTMFVGTVLGSIIQTMNHEIGVEVTELVGRYLKSIADLSHFEKEMLSDFLHEALA
>NZ_CP012712.1|WP_035502873.1|1057144_1059226_+|MMPL-family-transporter
MKSRIAIIVLSLILVIPALSGIVKTQINYDIFAYLPEKLPSVQGQNIMNKVFGFGGTGILMVKNQTDVEVENLKRKLEQVDGVETVNWITDIADLAVPREFLPEELVDQFYSGNSTIMQIQFEEEAASEKTHYAVQEIKNILGPNTYFAGTPPMLSELRQLLESEKFVYAVSAIGFILLLLGLTLPSLFIPFLILFSIGVSIIYNLGLAYYLNGSMSYVTAAIAGALQLGVTMDFSIFLVHRYEEERKTKEKNEAMIAAIKHTAMAILTSSATAVAGFLAMVTMSLGLGEDLGMTMARGILLSVLMILTLLPSFILVFDKWIREYQHRVMIPNFHLLAKFVTNRHKLVFVVFLLLFIPAFLGFKNVHIVYDLEQLMPKTLPSIQNLDEIKKEFTSTDSAFLVMDSKISDQERLKIKQQIGEIDGIKKVIGYDTFADPAIPSEFVPENLKNMFIKDQYNYMLVQMEYGSYDERTTRAIQQINKLTEPYEGHMYLTGQAVLQNDLTTTVRDDMKKVDVISVVAVFLIIALAFRSVALPVVLVGGIELAILFNQGLDFYLGRSMPFIGTFAIGAIQLGSTINYAILLVTRYKEELMNYPKEEAMYRAITASGEAILSSALALFAAVIGIWLFSDITLLRDLTFMIARGAIISLAVILFLLPAVLLTLESFISKTTFGWPKAKSMKEDETLSELSLN
>NZ_CP012712.1|WP_003253145.1|1059257_1059746_+|hypothetical-protein
MNAVKATIPVLTAATLLLSSATGTYAAAPDQVVDRETVYTLLNSDGTVKKSIVVDWLYFKGNGNVTVTDYGPLQHIRNISGLEKPVVQNGQIIWDAEVKGERSIYYSGETSQPLPVDVSINYYLNGEKSGCSLIGREKWHSKNRDNVEEPAETKEKHFLFRL
>NZ_CP012712.1|WP_042383925.1|1059696_1060764_+|hypothetical-protein
MKNQLKQKKNISYSGYKGVRHSVEKELYTPILSLVSLNIPTEHFTDMKLGDAMTVMSGKTMSATWMIVPNPEETITLEMKGTDIELEPITITLIPKLPPVSEVPVKEQLEKLTDGIQQISSALDQIGDGANQLASGNRQVKNGLNQLSEGLGQLNQVNQAHEGLVKQSLETNRQLLALAQNLAAEKPQDANLQALVQGLKGQQQMLKMLAEGGNLQGKPFPGLDKMEEGLKGSKAGADKLAVAAGQLEKGSLQLKTGIEKLSGGTAEIKNGLITGLNKLYEGEAILHQSKTAAEQYDTFLGKPKGAKGEVRFILKTDPIEPVKAKGSAEQKPDTGSEEESISFFAKVKKWLSDLF
>NZ_CP012712.1|WP_003253142.1|1060813_1061587_+|patatin-like-phospholipase-family-protein
MKVGLALGGGAVRGLAHIGVLKVLKKHQIPIDFIAGTSMGGAIGGLVAAGIDIEEMEEFILTTPSYRFVDIGILKRGIFAGNKIYAMLIQFLEQKGLGNIRIEDLNIPFRAVSVDLIKGEVFVFEKGSLSLAIRATTSVPGIFSPVHYQDKVLVDGGILNNLPADLLREAGMDVVMAVDVEREHEEEEPRNIFDVVYRSFTIMMTRQRRANLRYADVVFRPEVGHILAFDTTRIQECIEAGEREAQQKIQEVLSFIK
>NZ_CP012712.1|WP_003253141.1|1061946_1063020_+|ABC-transporter-ATP-binding-protein
MEKEAIIRFERVTKEYDGLVVLDDVSFEIERGKFYTLLGPSGCGKTTILRLIAGFAEPTKGTIYFHGKPVNHVPANKRQVNTVFQDYALFPHLNVFENVAFGLRIKKKKRSEIEEKVQQALRFVNLEGYENRSIQEMSGGQRQRVAIARAIVNEPEVLLLDEPLSALDLKLRTEMQYELRELQRRLGITFIFVTHDQEEALAMSDQIFVLNKGKIQQSGTPKDIYDEPVNRFVADFIGESNILRGTMIEDYLVEFAGKRFTCVDKGFRPNEPVDVVIRPEDLEITTKDQGKLQVRVDSQLFRGVHYELCCYDEDGNEWLVHSTKKAEVGEEIGLYFDPEDIHVMHISEDDGEGSDEK
>NZ_CP012712.1|WP_003253139.1|1063009_1063801_+|ABC-transporter-permease
MKNSVRNVYLLPYIIWIGLFVVAPILLILYYSFFDIDGNWTFANYKTFFTPIYLKMAASSVWYAFLITFFSLLVAYPTAYFLTKTKHKQLWLLLMILPTWVNLLLKVYAFLGIFGTYGLANAILETIGIGTKQILFTDFSFVFVSVYIFIPFMILPIFNSLEELNPTLIDAARDLGASAWTTFRRVVFPLTLDGVKAGCQAVFIPALSLFMITRLVAGNRVITLGTAIEEHFLVTQNWGMGSTIAVFLIIAMAIVVIMTGNRK
>NZ_CP012712.1|WP_003253137.1|1063811_1064618_+|ABC-transporter-permease
MRSNKKWATVYLVFVFLILYTPIIYLIYYSFNSGGMMHDFQHFTLKWYQEVLHDTRLWIIVLNTLTIALLSAAISTILGVIGALAIYYVKKRHMKQLLLTLNNVLIVSPDVIIGASFLILFTIIGIQLGFTSVLLSHIAFSVPIVVLMVLPKLQEMSPTLIDAARDLGANQWDVLTKVILPFITPGIFAGFFMALTYSLDDFAVTFFVTGNGFSTLSVEIYSRARQGISLSINALSTLLFLFTVVLVIGYYFISQKSSTLYGMRGRRK
>NZ_CP012712.1|WP_013401689.1|1064614_1065688_+|ABC-transporter-substrate-binding-protein
MRKLISLFAAVFFASFVLLYVSALLNKTEGYSGKNTLTVYNWGDYIDPALIKKFEKQTGIKVIYQTFDSNEAMMAKIAQGGTTFDVAVPSEYAISKMKEEGLLIPLDHSKLPNLKYINPRFLNLSFDPGNKYSVPYFWGTVGIVYNPEMIGGKKITSWNDLWDKDLRNQILLVDGAREVIGMGLNSLHYSLNDTNKKHLQEAKEKLDRLTPNVKAIVGDEIKMLLVNEEAAIGVVWSGDAAEIIAENDKLDYVVPKEGSNLWFDNMVIPKTAKNIEGAHQFINFMLDPKNAAQNAEYVGYSTPNEKALDYLPKEVTEDKRFYPDFESVGNLEVYENLGKRMLAYYNELFLQFKMHRK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP012712_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012712_5

1364439-1364538

Orphan

Consensus_repeat	Method
TGTCTTTCACAAACACCTCATTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012712_5

>merge|NZ_CP012712|5|1364439-1364538|CRISPRCasFinder
TGTCTTTCACAAACACCTCATTTGTTAAGGAGTTTCGCGTTTTCTCACCGCATATAACGGTGTTGCTTCGATAATGGTGTCTTTGACAAACACCTCATTT

>NZ_CP012712|5|5|1364439-1364538|CRISPRCasFinder
TGTCTTTCACAAACACCTCATTT	GTTAAGGAGTTTCGCGTTTTCTCACCGCATATAACGGTGTTGCTTCGATAATGG
TGTCTTTGACAAACACCTCATTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012712.1\|WP_013401511.1\|1361231_1361849_+\|HTH-type-transcriptional-regulator-Hpr	unknown	unknown	gnl\|CDD\|237501
NZ_CP012712.1\|WP_042383683.1\|1369043_1370081_+\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NZ_CP012712.1\|WP_003252550.1\|1362911_1363748_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|179537
NZ_CP012712.1\|WP_042383687.1\|1365440_1366637_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|377581
NZ_CP012712.1\|WP_013401510.1\|1362381_1362561_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_003252530.1\|1371045_1372482_+\|protoporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|237009
NZ_CP012712.1\|WP_013877361.1\|1367325_1368726_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_042383685.1\|1366649_1367153_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|225209
NZ_CP012712.1\|WP_003252551.1\|1361841_1362183_-\|YhaI-family-protein	unknown	unknown	gnl\|CDD\|370213
NZ_CP012712.1\|WP_003252557.1\|1359116_1360199_+\|3-phosphoserine/phosphohydroxythreonine-transaminase	unknown	unknown	gnl\|CDD\|235428
NZ_CP012712.1\|WP_071880410.1\|1362630_1362720_-\|YjcZ-family-sporulation-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_013401503.1\|1375738_1375876_-\|YhfH-family-protein	unknown	unknown	gnl\|CDD\|379490
NZ_CP012712.1\|WP_013401504.1\|1373208_1375611_+\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
NZ_CP012712.1\|WP_003252556.1\|1360310_1360835_+\|tryptophan-transporter	unknown	unknown	gnl\|CDD\|293704
NZ_CP012712.1\|WP_013401512.1\|1358822_1359008_+\|sporulation-YhaL-family-protein	unknown	unknown	gnl\|CDD\|290852
NZ_CP012712.1\|WP_003252559.1\|1357659_1358643_+\|3'-5'-exoribonuclease-YhaM	unknown	unknown	gnl\|CDD\|237394
NZ_CP012712.1\|WP_042383681.1\|1370094_1371030_+\|ferrochelatase	unknown	unknown	gnl\|CDD\|183526
NZ_CP012712.1\|WP_003252547.1\|1364706_1365444_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP012712.1\|WP_003252549.1\|1363789_1364212_-\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611
NZ_CP012712.1\|WP_013401505.1\|1372567_1373140_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
NZ_CP012712.1\|WP_013401511.1\|1361231_1361849_+\|HTH-type-transcriptional-regulator-Hpr	gnl\|CDD\|237501	PRK13777, PRK13777, HTH-type transcriptional regulator Hpr.	2.99262e-128
NZ_CP012712.1\|WP_042383683.1\|1369043_1370081_+\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	0
NZ_CP012712.1\|WP_003252550.1\|1362911_1363748_+\|peptidylprolyl-isomerase	gnl\|CDD\|179537	PRK03095, prsA, peptidylprolyl isomerase PrsA.	1.33826e-66
NZ_CP012712.1\|WP_042383687.1\|1365440_1366637_+\|ABC-transporter-permease	gnl\|CDD\|377581	pfam05975, EcsB, Bacterial ABC transporter protein EcsB. This family consists of several bacterial ABC transporter proteins which are homologous to the EcsB protein of Bacillus subtilis. EcsB is thought to encode a hydrophobic protein with six membrane-spanning helices in a pattern found in other hydrophobic components of ABC transporters.	7.41248e-113
NZ_CP012712.1\|WP_003252556.1\|1360310_1360835_+\|tryptophan-transporter	gnl\|CDD\|293704	pfam17099, TrpP, Tryptophan transporter TrpP. TrpP is a bacterial transmembrane protein that is probably involved in tryptophan uptake. Its expression is regulated by tryptophan-activated RNA-binding regulatory protein (TRAP).	1.07855e-40
NZ_CP012712.1\|WP_003252530.1\|1371045_1372482_+\|protoporphyrinogen-oxidase	gnl\|CDD\|237009	PRK11883, PRK11883, protoporphyrinogen oxidase; Reviewed.	0
NZ_CP012712.1\|WP_042383685.1\|1366649_1367153_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	1.88052e-16
NZ_CP012712.1\|WP_003252551.1\|1361841_1362183_-\|YhaI-family-protein	gnl\|CDD\|370213	pfam08963, DUF1878, Protein of unknown function (DUF1878). This domain is found in a set of hypothetical bacterial proteins.	3.44416e-48
NZ_CP012712.1\|WP_003252557.1\|1359116_1360199_+\|3-phosphoserine/phosphohydroxythreonine-transaminase	gnl\|CDD\|235428	PRK05355, PRK05355, 3-phosphoserine/phosphohydroxythreonine transaminase.	0
NZ_CP012712.1\|WP_013401503.1\|1375738_1375876_-\|YhfH-family-protein	gnl\|CDD\|379490	pfam14149, YhfH, YhfH-like protein. The YhfH-like protein family includes the B. subtilis YhfH protein, which is functionally uncharacterized. Its expression is repressed by the Spx paralogue MgsR, which regulates genes involved in stress response. This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 53 amino acids in length.	3.88651e-14
NZ_CP012712.1\|WP_013401504.1\|1373208_1375611_+\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	1.16036e-162
NZ_CP012712.1\|WP_003252559.1\|1357659_1358643_+\|3'-5'-exoribonuclease-YhaM	gnl\|CDD\|237394	PRK13480, PRK13480, 3'-5' exoribonuclease YhaM; Provisional.	0
NZ_CP012712.1\|WP_013401512.1\|1358822_1359008_+\|sporulation-YhaL-family-protein	gnl\|CDD\|290852	pfam14147, Spore_YhaL, Sporulation protein YhaL. This family of proteins is involved in sporulation. In B. subtilis its expression is regulated by the early mother-cell-specific transcription factor sigma-E.	7.2104e-19
NZ_CP012712.1\|WP_042383681.1\|1370094_1371030_+\|ferrochelatase	gnl\|CDD\|183526	PRK12435, PRK12435, ferrochelatase; Provisional.	0
NZ_CP012712.1\|WP_003252547.1\|1364706_1365444_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.99434e-81
NZ_CP012712.1\|WP_003252549.1\|1363789_1364212_-\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	1.7969e-57
NZ_CP012712.1\|WP_013401505.1\|1372567_1373140_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.70149e-15

>NZ_CP012712.1|WP_003252549.1|1363789_1364212_-|HIT-family-protein
MSECIFCKIVNGDIPAAKVYEDENVLAFLDISQVTKGHTLVIPKVHKANIFELTPDVASHVFTAIPKIANAIKKQFSPVGLNLLNNNGEQAGQTVFHYHVHLIPRYGKGDGFGAVWKSHASDYTFDDLQDIAATIQKGLQ
>NZ_CP012712.1|WP_003252550.1|1362911_1363748_+|peptidylprolyl-isomerase
MKKWMIAAAVASVFALSACSNGDSEVIVKTKDGDITKEEFYNEMKARVGKEVIRDLVHEKVLSKKYKVTDKEIDKEIENLKDMYGVQYDLVVQQNGEKAIRDMVKLDLLRQKAAMEDIKVTDKELKDYYENYKPKIRASHILVKDEKTAKEIKAKLDKGEDFAKLAKQYSQDPGSASNGGDLGWFGQGKMVKEFEDAAYKLKVGEISDPVKTEYGYHIIKVTDKEEKKPFNEMKEEIEFEVKRSKLDPAKMQAKVEKLVKDAKADIKDKDLQDALKQQ
>NZ_CP012712.1|WP_071880410.1|1362630_1362720_-|YjcZ-family-sporulation-protein
MSGAPYAGGFALIVVLFILLIIVGCACLF
>NZ_CP012712.1|WP_013401510.1|1362381_1362561_+|hypothetical-protein
MTVYFIPLAVIILFLINQLTSRLCAQREIPEEKQPGVFRTINVLITILLITSYFEVLFT
>NZ_CP012712.1|WP_003252551.1|1361841_1362183_-|YhaI-family-protein
METLEERIAKLEFHRSLLMEMVDKTKKPFYYLVIQANLTKEEVDEVLALCQQLSEEYEKQKAEGLTIFTPLLLHFAGMLHPSLPLEQTIDALLQQQMFVPLMTELKKLIQTVS
>NZ_CP012712.1|WP_013401511.1|1361231_1361849_+|HTH-type-transcriptional-regulator-Hpr
MGGTMKTTEQNYSIKEALLFSQRIAQLSKALWKSIEKDWQQWIKPFDLNINEHHILWIAYHFKGASISEIAKFGVMHVSTAFNFSKKLEERGLLSFSKKQDDKRNTYIELTEKGEEVLLKLMESYDPTKNAVFNGALPLRDLYGKFPEILEMMCIIRNIYGDDFMEIFERAFENIKSDFVEQDGKLVKRNARPQEKEKELTSQPS
>NZ_CP012712.1|WP_003252556.1|1360310_1360835_+|tryptophan-transporter
MNTRVLVSLALLVGIGAVLHAVIPGIFFGMKPDMMLTMMFLAILLFPNVKTAGLVGIVTGVISAMTTGFPGGQVPNIIDKIITAFVFFAFVCLLKKYGQTVVSAAILTAVGTVISGTIFLTAALLFAGLPGGATFSALFLTVVLPATAINTIVMVIIYPIVSAIFKRMNITVHV
>NZ_CP012712.1|WP_003252557.1|1359116_1360199_+|3-phosphoserine/phosphohydroxythreonine-transaminase
MKRAYNFNAGPSALPLPVLKRAQEELLNFQNTGMSVMELSHRSKEYDAVHNSAKQRLKKLMNIPDTHDILFLQGGASLQFSMVPMNLLGKDKVANYVLTGSWSEKALKEAKKIGKTHIAASSKEANYTYIPRLEDIQLSENAAYLHITSNNTIFGTQWREFPDLPVDLVADMSSDILSREINVGQFALIYAGAQKNLGPSGVTVVIIRNDLLERIPDNLPTMLDYRTHSSSNSLYNTPPTFAIYMLSLVLEWVEEQGGVKAIEARNKEKAAVVYEAIDASNGFYAPHAEKDSRSLMNVTFTLPNEELTKQFLAEAKEKGFVGLAGHRSVGGCRASIYNAVPLEACEALAGFMNDFYRRFS
>NZ_CP012712.1|WP_013401512.1|1358822_1359008_+|sporulation-YhaL-family-protein
MLSMPWWIYLVVAGIIFSGYMTVRTAAREREIDEAMIEKEGEIYMERIREERKRRQQAKSL
>NZ_CP012712.1|WP_003252559.1|1357659_1358643_+|3'-5'-exoribonuclease-YhaM
MAKGIIHYDVGEQVDVYLLIKSVTKGIASNGKPFLTLILQDKTGDIEAKLWDVSPEDENVYVPESIVKVFGDIHNYRGKTQLRIRSIRPARAGDDVRVSDFLETAPMKREEMMEKITQYILDMENPNIQRITRYLLKKYEQKFFDYPAATKNHHEFISGLAYHVVSMLELATALVNLYPSLNKDLLYAGVILHDLGKVIELSGPVSASYTLEGNLLGHISIMVSEISKAAEHLGISGEEVVVLQHMVLSHHGKTEWGSPKPPMVKEAEILHYIDNLDAKLNMIDRALEKVKPGEFTERIFALENRSFYKPMFLSAPAVSKQEKRGIS
>NZ_CP012712.1|WP_003252547.1|1364706_1365444_+|ABC-transporter-ATP-binding-protein
MALLEVHHLYGGYTKQNVLEDVSFTVDRGEIVGLIGLNGAGKSTTIKHIIGLMEPRKGTITINGTMFSEQPDAYRSQFTYIPETPILYEELTLEEHLQLTAMAYGLEKSEYERRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLVEPALYIIDEPFLGLDPLGIHSLLEQMQRMKKKGAGILMSTHILATAEKYCDSFVILHNGKVRAKGTMAELREQFSSPAATLDELYIELTKEDSV
>NZ_CP012712.1|WP_042383687.1|1365440_1366637_+|ABC-transporter-permease
MINGKRLWNDRLYQEARKMRRYLRYMLNDHLLFILLIGIGLGAVAYRHWVQTLPPHFPYPIVAALVFSFMLTFGSLRTLFQEADIVFLLPAETKLGPYIQRAFLLSFLLQAYGLLLIWLAVAPLHQKFSDVSIWRLFLVLLVLKGWNLFISWKGNYFIESLTHRLSALSRFGLNAAFVYFLLADASFFFLLAICALMAGITFYVVQATKRKGWKWERIIEQEAKAVRAFYRIANLFTDVPQWKEEAKRRRWLDFLISMIPYQQKNTFLYLYVRTFLRSGGYFSLYVRLIAIGLLLLYIVPTEYGKIAASLFFLYITGFQLFALIDHHRTNLLIRLYPLPDDVRKQAVCRLLFFLLIVQNSVFSLFLFLLDAGVIWMVSWAAGAVFSYWLLFHYLKRRK
>NZ_CP012712.1|WP_042383685.1|1366649_1367153_+|antibiotic-biosynthesis-monooxygenase
MKKMYITTGTTDYLQKVKDMHKNETMLLLEREEDAVLLHETDGETVFKEPRCYEVIDAAGELGGAFVVCNNIPVTDEGRPLFEHRFQQRARLIENEPGFVAIRVLRPLSNDTYVIMTLWEAKKYFEQWQRSNAFAKAHAQRKEEQKPSRQIFPRPSYVTTYSVVQER
>NZ_CP012712.1|WP_013877361.1|1367325_1368726_+|hypothetical-protein
MGVELTVLHWIYLAFIVLIIGFMIARKDTSLVCIVGIFLLSVAATHSLSAAISGVFHSFIYAMTELLPTILVISIIVAMSKAMTATGINDVMVSPFTRFIRTPGWAYWTIGILMMVISCFFWPSPAVALMGAVLLPVAIRVGLPPLGAAMTMNLFGHGVALSGDFVIQGAPKLTADAAGLPVSEVIAASVPLVLVMGATTTLTAFLLLRRDMKRGYFANEANEVAVTADAALEKTKRLLSNQVKNMLAAIIPAMFVLDVIAMFYLRLQGGEATALIGGTAIFILILISIFAHKKESFGEITNYLVEGFQFGIKVFAPVVPIAAFFYLGDAGFAKIIGEHLPKLSQGIVNDLGVALAHIVPLNNGIGAVTLTVVGAITGLDGSGFSGISLAGSVAHLFATAIGGGAATLTALGQIAAIWVGGGTLVPWALIPAAAICGVDPFELARRNLVPVTVGIVITTIVAMFLM
>NZ_CP012712.1|WP_042383683.1|1369043_1370081_+|uroporphyrinogen-decarboxylase
MSKWMNDTFLRACRGEKTDYVPVWYMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTRLPVEQYNVDAAILYKDIMSPLPAIGVDVEIKAGVGPVIANPIRSMADVERLGEIHPEEDVPYVLETIKLLTTEQLNVPLIGFAGAPFTLASYMIEGGPSKNYNKTKAFMYAEPKAWFALMDKLADMTIRYVKAQIRAGADAIQIFDSWVGAVSVDDYRTFIKPTMARIFAALREENVPLIMFGVGASHLAKEWNDLPLDVIGLDWRLSLREARQSGITKALQGNLDPAVLLAPWEVIEKRVKQILDEGMERPGYVFNLGHGIFPEIRPETLKRLTAFIHEYTSRK
>NZ_CP012712.1|WP_042383681.1|1370094_1371030_+|ferrochelatase
MAKKKMGLLVMAYGTPYKEEDIERYYTHIRHGRKPSPELLEDLKQRYKAIGGISPLAQITLDQAKQLEKRLNSVQDDMEFQMYLGLKHIEPFVEDAVRQMHEDGIEEAVGIVLAPHFSTFSIQSYNERAKAEAEKLGGPVIYTIDSWYDEPKFIDYWVEKVKEVFASMSEEECDKAVLIVSAHSLPEKIIAAGDPYPQQLAETAKLIAEKAGVKHYAVGWQSAGNTPEPWLGPDVQDLTRQLHQEHGYTSFVYVPAGFVADHLEVLYDNDIECKQVTEEIGANYYRPEMPNTNAKFIDALATVVLKRTKLL
>NZ_CP012712.1|WP_003252530.1|1371045_1372482_+|protoporphyrinogen-oxidase
MNDEKYTVVIIGGGITGITAAYYLQKAVKERQLPIECKLVEATHRLGGKVQTVVRDGFVIERGPDSFLARKTSAFRLVREVGLENEIVHNATGKSYILVNGKLYPIPGGAIMGIPTQIGPFITTRLFSPLGKLRAAFDFILPPTKAEGDLSLGQFFRRRLGDEVVDNLIEPLLSGIYAGDIDQMSLMATFPQFFQIEQKYGSLVLGAKRTAPKAQKERKGAFQTLKTGLQSLVDEVEKRMEQGSVIKGVRVERVWREGTGYRLRLSNGDIWKADSIIVAAPHSSVPAMFADYPFFEPFQSIPSTSVATVALAFPESAIEQDIDGTGFVVSRRNDYTITACTWTHKKWPHTAPDGKALLRCYVGRPGDEEIVEQSDDEIVRVVMDDLSKIMRISGRPELIAISRWKEAMPQYTVGHKERLAKIKTHMDAELPGVFLAGSSYEGLGLPDCIDQGENAVKKVLDYLQTAPRKLAEVNSKMS
>NZ_CP012712.1|WP_013401505.1|1372567_1373140_+|TetR/AcrR-family-transcriptional-regulator
MSIDRKRQIIEAAAKSFSLFGYKATTMEQIAKLANVGKGTIYTFFKNKEDLLDAIVSSLILEIIEEAEQAMDPDRPFSENAHRALYRILEFRQQHQLTAKLLQEVRNLGTPAVQEVMKKLDLAIIDYIRKKIDIAIKKGEIRDCDAEITAFLMLKTYIALIVDWEKDHEPLTKEEIAQLFELYFLKGLSK
>NZ_CP012712.1|WP_013401504.1|1373208_1375611_+|YhgE/Pip-domain-containing-protein
MRGFSLLWKEAEAIFRNRKVLISIIAVICIPLLYSGMFLWAFWDPYAHLDQLPVAVVNNDKGATMNGEKLEIGDKLVEKLKENKKFDWHFVSEKEAEKGLQHQTYYMAIEIPDDFSKNATTLQTEHPKPMKLIYKPNEAFNFLSAQIGDSAVEKIKEEISNTVTETYVEAMFDNIREMANGLNQASDGAKQLHDGIKKAKDGGAALQSGLHSAKEGSGKLQQGAHAAKNGADELYKNLKLLAEKSLMFENGMQSASDGADRLNEGLHQLQNGFAKMQEGHSQLLAGAKQVENGAKQLSGGLHQSLDGMEQMKGNIPQLTKGTQDLQNGAQQLSASMEQWQQGAEKTNKGALQVSQGLEKAVEQLDALAAQATDPNEKVLLQTLKQQLLPLSEGSKQVAQGTEQLANSASQLKTGADQLAEGASRLHNGQLALSKGVETLLAGQQRLANGADALVAGQSKVVQGLTTFGEKLQEGKNGVQQLASGSNQLSSGLRQLAQGSSQFKDGTNQLADGSGKLASGINDLENGATALSNGMNQLANGSDQLVNGMKKLDDGSNELADKLTDGAKKASDVKANDDVYKMFADPVKKNNEKMHHVPNYGTGFTPYFLSLGLFVGALLLSIVFPLREPVGVPKSGFSWFIGKFGVLLVIGVIQSLLVDALLLGALDIHVKSVPRFVLFTIITSITFITLIQFLVTTLGDPGRFIGIIILILQLTTSAGTFPLELIPSELQHFNAWLPMTYSVHGFKAVISSGDFAFMWHNAAILALFIAVFITATISYFLVQHKRKFYTVAQQMNKASEA
>NZ_CP012712.1|WP_013401503.1|1375738_1375876_-|YhfH-family-protein
MLGKVLEFFKNLPPKKCVQCGKEIEEQHECYGNTCEDCLGAAYHQ

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP012712_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012712_6

2189422-2189518

Orphan

Consensus_repeat	Method
GAAAGCAATGAAAGTATTAGATGTTCAGGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012712_6

>merge|NZ_CP012712|6|2189422-2189518|CRISPRCasFinder
GAAAGCAATGAAAGTATTAGATGTTCAGGGACAAGGTGGATCCGAAAAAACATCAGGGGCATTCTGGAAAGCAATGAAAGTATTAGATGTTCAGGGA

>NZ_CP012712|6|6|2189422-2189518|CRISPRCasFinder
GAAAGCAATGAAAGTATTAGATGTTCAGGGA	CAAGGTGGATCCGAAAAAACATCAGGGGCATTCTG
GAAAGCAATGAAAGTATTAGATGTTCAGGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012712.1\|WP_042386085.1\|2184282_2185359_-\|iron-containing-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|341451
NZ_CP012712.1\|WP_013401057.1\|2184158_2184353_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_157777078.1\|2191180_2191543_+\|DUF5085-family-protein	unknown	unknown	gnl\|CDD\|374871
NZ_CP012712.1\|WP_013401060.1\|2182832_2183126_+\|4a-hydroxytetrahydrobiopterin-dehydratase	unknown	unknown	gnl\|CDD\|376528
NZ_CP012712.1\|WP_167542249.1\|2191083_2191242_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_045844694.1\|2188702_2188984_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_003251178.1\|2181653_2182484_+\|nicotianamine-synthase	unknown	unknown	gnl\|CDD\|308600
NZ_CP012712.1\|WP_042386083.1\|2186499_2187897_+\|membrane-protein	unknown	unknown	gnl\|CDD\|288673
NZ_CP012712.1\|WP_042386338.1\|2189084_2189369_+\|YwqI/YxiC-family-protein	unknown	unknown	gnl\|CDD\|375099
NZ_CP012712.1\|WP_042385573.1\|2194709_2195114_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|227161
NZ_CP012712.1\|WP_003251153.1\|2192635_2193433_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|372253
NZ_CP012712.1\|WP_013401058.1\|2183809_2183989_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_042385589.1\|2197462_2198485_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|225070
NZ_CP012712.1\|WP_003251156.1\|2191746_2192646_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP012712.1\|WP_042385576.1\|2193432_2194110_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP012712.1\|WP_042385588.1\|2198554_2199265_+\|iron-sulfur-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|366850
NZ_CP012712.1\|WP_013401059.1\|2183148_2183685_+\|YdbC-family-protein	unknown	unknown	gnl\|CDD\|374476
NZ_CP012712.1\|WP_003251180.1\|2180338_2181643_+\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240541
NZ_CP012712.1\|WP_003251161.1\|2190627_2191080_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_042385570.1\|2195547_2196015_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|214628

Protein	Function_ID	Function_description	E-value
NZ_CP012712.1\|WP_042386085.1\|2184282_2185359_-\|iron-containing-alcohol-dehydrogenase-family-protein	gnl\|CDD\|341451	cd08172, GlyDH-like, Glycerol_dehydrogenase-like. This family contains glycerol dehydrogenase (GlyDH)-like proteins that have yet to be characterized, but show sequence homology with glycerol dehydrogenase. Glycerol dehydrogenases (GlyDH) is a key enzyme in the glycerol dissimilation pathway. In anaerobic conditions, many microorganisms utilize glycerol as a source of carbon through coupled oxidative and reductive pathways. One of the pathways involves the oxidation of glycerol to dihydroxyacetone with the reduction of NAD+ to NADH catalyzed by glycerol dehydrogenases. Dihydroxyacetone is then phosphorylated by dihydroxyacetone kinase and enters the glycolytic pathway for further degradation. The activity of GlyDH is zinc-dependent; the zinc ion plays a role in stabilizing an alkoxide intermediate at the active site.	0
NZ_CP012712.1\|WP_042385573.1\|2194709_2195114_+\|phage-holin-family-protein	gnl\|CDD\|227161	COG4824, COG4824, Phage-related holin (Lysis protein) [General function prediction only].	4.05432e-37
NZ_CP012712.1\|WP_003251178.1\|2181653_2182484_+\|nicotianamine-synthase	gnl\|CDD\|308600	pfam03059, NAS, Nicotianamine synthase protein. Nicotianamine synthase EC:2.5.1.43 catalyzes the trimerisation of S-adenosylmethionine to yield one molecule of nicotianamine. Nicotianamine has an important role in plant iron uptake mechanisms. Plants adopt two strategies (termed I and II) of iron acquisition. Strategy I is adopted by all higher plants except graminaceous plants, which adopt strategy II. In strategy I plants, the role of nicotianamine is not fully determined: possible roles include the formation of more stable complexes with ferrous than with ferric ion, which might serve as a sensor of the physiological status of iron within a plant, or which might be involved in the transport of iron. In strategy II (graminaceous) plants, nicotianamine is the key intermediate (and nicotianamine synthase the key enzyme) in the synthesis of the mugineic family (the only known family in plants) of phytosiderophores. Phytosiderophores are iron chelators whose secretion by the roots is greatly increased in instances of iron deficiency. The 3D structures of five example NAS from Methanothermobacter thermautotrophicus reveal the monomer to consist of a five-helical bundle N-terminal domain on top of a classic Rossmann fold C-terminal domain. The N-terminal domain is unique to the NAS family, whereas the C-terminal domain is homologous to the class I family of SAM-dependent methyltransferases. An active site is created at the interface of the two domains, at the rim of a large cavity that corresponds to the nucleotide binding site such as is found in other proteins adopting a Rossmann fold.	7.52377e-15
NZ_CP012712.1\|WP_042386083.1\|2186499_2187897_+\|membrane-protein	gnl\|CDD\|288673	pfam11840, DUF3360, Protein of unknown function (DUF3360). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 489 to 517 amino acids in length.	5.14083e-05
NZ_CP012712.1\|WP_003251180.1\|2180338_2181643_+\|MATE-family-efflux-transporter	gnl\|CDD\|240541	cd13136, MATE_DinF_like, DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	3.63855e-144
NZ_CP012712.1\|WP_042385588.1\|2198554_2199265_+\|iron-sulfur-cluster-assembly-protein	gnl\|CDD\|366850	pfam01883, FeS_assembly_P, Iron-sulfur cluster assembly protein. This family has an alpha/beta topology, with 13 conserved hydrophobic residues at its core and a putative active site containing a highly conserved cysteine. Members of this family are involved in a range of physiological functions. The family includes PaaJ (PhaH) from Pseudomonas putida. PaaJ forms a complex with PaaG (PhaF), PaaI (PhaG) and PaaK (PhaI), which hydroxylates phenylacetic acid to 2-hydroxyphenylacetic acid. It also includes PaaD from Escherichia coli, a member of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation. Furthermore, several members of this family are shown to be involved in iron-sulfur (FeS) cluster assembly. Iron-sulfur (FeS) clusters are inorganic co-factors that are are able to transfer electrons and act as catalysts. They are involved in diverse cellular processes including cellular respiration, DNA replication and repair, antibiotic resistance, and dinitrogen fixation. The biogenesis of such clusters from elemental iron and sulfur is an enzymatic process that requires a set of specialized proteins. Proteins containing this domain include the chloroplast protein HCF101 (high chlorophyll fluorescence 101), which has been described as an essential and specific factor for assembly of [4Fe-4S]-cluster-containing protein complexes such as the membrane complex Photosystem I (PSI) and the heterodimeric FTR (ferredoxin-thioredoxin reductase) complex and is involved in the assembly of [4Fe-4S] clusters and their transfer to apoproteins. The mature HCF101 protein contains an N-terminal DUF59 domain as well as eight cysteine residues along the sequence. All cysteine residues are conserved among higher plants, but of the two cysteine residues located in the DUF59 domain only Cys128 is highly conserved and is present in the highly conserved P-loop domain of the plant HCF101 (CKGGVGKS). SufT protein from Staphylococcus aureus is composed of DUF59 solely and is shown to be involved in the maturation of FeS proteins. Given all this data, it is hypothesized that DUF59 might play a role in FeS cluster assembly.	4.82532e-12
NZ_CP012712.1\|WP_013401060.1\|2182832_2183126_+\|4a-hydroxytetrahydrobiopterin-dehydratase	gnl\|CDD\|376528	pfam01329, Pterin_4a, Pterin 4 alpha carbinolamine dehydratase. Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerization cofactor of hepatocyte nuclear factor 1-alpha).	8.53903e-36
NZ_CP012712.1\|WP_042385589.1\|2197462_2198485_+\|amidohydrolase	gnl\|CDD\|225070	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	4.14043e-40
NZ_CP012712.1\|WP_003251156.1\|2191746_2192646_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	6.69824e-89
NZ_CP012712.1\|WP_042385576.1\|2193432_2194110_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.37269e-13
NZ_CP012712.1\|WP_042386338.1\|2189084_2189369_+\|YwqI/YxiC-family-protein	gnl\|CDD\|375099	pfam17279, DUF5344, Family of unknown function (DUF5344). This is a Bacterial family of unknown function. Most of the members of this family are predicted to contain a coiled-coil region.	2.55247e-19
NZ_CP012712.1\|WP_013401059.1\|2183148_2183685_+\|YdbC-family-protein	gnl\|CDD\|374476	pfam16291, DUF4937, Domain of unknown function (DUF4937. This family consists of uncharacterized proteins around 120 residues in length and is mainly found in various Bacillus species, such as Bacillus subtilis and Bacillus amyloliquefaciens. Several members are annotated as ydbC, but the specific function of this family is unknown.	4.6067e-38
NZ_CP012712.1\|WP_157777078.1\|2191180_2191543_+\|DUF5085-family-protein	gnl\|CDD\|374871	pfam16895, DUF5085, Domain of unknown function (DUF5085). This protein is believed to be involved in the type VII secretion system.	0.00041196
NZ_CP012712.1\|WP_003251153.1\|2192635_2193433_+\|ABC-transporter-permease	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	1.00412e-30
NZ_CP012712.1\|WP_042385570.1\|2195547_2196015_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|214628	smart00344, HTH_ASNC, helix_turn_helix ASNC type. AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli).	8.34037e-35

>NZ_CP012712.1|WP_042386338.1|2189084_2189369_+|YwqI/YxiC-family-protein
MSGEIKIVYEEVESSITNMERATQSLEPVFPSSLGGENALDVVTRLNELMQALQQTFLAYKELLIQNEIDTRQSVQMMRRTDEEVATGISRPSH
>NZ_CP012712.1|WP_045844694.1|2188702_2188984_+|hypothetical-protein
MSLSSLYALLREKERQLMRLQTCESQLRQCQSEFFQQEHLCTKPELTAKTWHGNRAEQLDSLRDSGILWQYRVIEHVQFDDTLQALRNKIIQL
>NZ_CP012712.1|WP_042386083.1|2186499_2187897_+|membrane-protein
MKWKNRPHGAETPYIPAGPFKIRLPFIHYRFEWPDYVQGLLMCAVDLGAITLLTDHLGMPFEVALAVVILNGLLYLLHHLLGDPVIPGWVTPAIPLIVLFVKQFPEGPDRVYALIAFQLTLGILSIILGVTGLASKVVRLVPDAIKSGIILGAGIGAVVSIFEEGGKFESFPYTITICVGFAFYLIFSKHFETLKQKNKIWALLGNLGILPAILLAVIVAPLVGEAKWPDIQWGVSKPDFATLWSEYTVFGLGFPAFSFFVKAIPAVLATYLVVFGDVLKTKALLSESDIVRTDEKVDYNPNRAHLIFGGRNVLMSMIGPDITMCGPMWAAMQVVVIERFKKGKKAMHSFFGGAGSFRWGTNTGLFLLPIVSLVQPILGVALSLTLLVQGYVSVRIGVMQARSQRDLGIAGVVGAILVVKGATLAFAAGILLCILLYGKDFLLGENDRIFTHHSQEAEYKEKEAI
>NZ_CP012712.1|WP_042386085.1|2184282_2185359_-|iron-containing-alcohol-dehydrogenase-family-protein
MDMIEVRGAPNYYVCESGVLTHLEALLQKHGFKNVFVICGERSWKAAEPYFPKNGKLTYSFFRYNGECSLAEIERLSSLSVHFDVIIGIGGGKVLDLAKAVANQTHLDVVLIPTLASTCAAWTPLSVIYDENGTFIRYDIFPKSTLMVLVDTRILLHSPVVYLRAGIADTLAKWYEADCIIRQLSNPPLSVKIAHQTAYLCKTELLEHSRAAINDLVEKRDTLSFRKVIETIIMAGGMVGGFGDQYGRIAAAHSVHNGLTKVPETHHLLHGEKVAYGILVQLALEENWDEIHYLLPFYRDLKLPYTLKQLGLDATEKEKLTYIAEEIVQPHESIHLMNIPVDSEKIVQAFYQLEKLEV
>NZ_CP012712.1|WP_013401057.1|2184158_2184353_+|hypothetical-protein
MPMHTVKNHLKKNVTWQLARIPLYLLFNKFLYDAIMKTKERFKLLTSPVGKMLGRSSRYQPEYS
>NZ_CP012712.1|WP_013401058.1|2183809_2183989_+|hypothetical-protein
MNLVGHKIYLRFLKDTDAGPLAEMHRKNREFWQRYTPDRPEEFYTEEYQFHRKKFALFK
>NZ_CP012712.1|WP_013401059.1|2183148_2183685_+|YdbC-family-protein
MLLKWIRCEVDEEKKAAFSAAQETWRDLQGYPGFLGQIGGWNAAKPQEAWILAFWENLDFYQSFMSDKHDEILERSKQTGTYHNISVDIIEIKQRAEIPYISMAEVLQKSKMLYVISPNRLREKRLFSDTIKHGKHILATFRSAHQLAVLCASMEFHPSEWKNMPHTQVKLESAWTVV
>NZ_CP012712.1|WP_013401060.1|2182832_2183126_+|4a-hydroxytetrahydrobiopterin-dehydratase
MRLTEEELQAFLRGMEGWKLVEERWIAKKYRFQDYLQGIEFVRRIAAISEEANHHPFISIDYKLVTVKISSWRAKGLTKLDFELAKKYDEVYEKMKD
>NZ_CP012712.1|WP_003251178.1|2181653_2182484_+|nicotianamine-synthase
MPLAESFQLKEQIIEQYKHAYKILMAEHDLSPNNPIINETLYSLVNNLGQFFEHELEEEILSDREIGKIRSDMLRKLETAETLMEFYYAEKFIQDTPHINNLRKFIYWDNYKKLVDIELKKFFALAERQQLSAIAFVGSGPLPLSTILLQRQTGKPVVCLDINPAAYNIGKKLIDRYGLQHSLTYVLADGASYHYEGCDLVWIASLVPNKQEVVKRIYETNPNAVVAIRSVDGIYQLLYEPVDEAIFQHIIGKEIGRTKANSSIINSTIFYRFQHV
>NZ_CP012712.1|WP_003251180.1|2180338_2181643_+|MATE-family-efflux-transporter
MTHRAYLSLAIPLIISTITTPLLGAVDTAVVGQLSDPAYIGGVAVGTMIFNTMYWLFGFLRVSTSGFAAQAHGAQDSKQCFFYLVRPFLIALAIGLTFILFQWPIKHAALTLIDPDEKVTAFADEYFSIRIWGAPFVLANYVILGWLIGISRVKISLFLQVFMNLSNIALDLLFVNILHQDVKGVATATFISEAAAFLLGMYIVLKLSKIRFSAIFHSKLWNLGELKKMMAVNRDLFIRTICLLAVLNVFTARGASFGTEILAANAVLIQIHYIMAYFLDGFANASSILVGKAVGANDETLYKRTLSLSSQWAVISPLFMMLIYILFKNSIISVFTKNQEVIELASSYSIWITIFPLAASFGLILYGVFTGATVTAPIRNSMLISLALYIVFLLIFIPVFHNHGLWLAFIVFSLGRSLFLAMYVPMLNRTLFQK
>NZ_CP012712.1|WP_003251161.1|2190627_2191080_+|hypothetical-protein
MGIEVRSLIFDNLLIYETRQRKQNWLETYFWMEDFTLTHGIYKNGPVFFSVSEESSDDASAHFTYYLPINEPVQLTDETHFRFQRKLHIKKALVLRQADEELDFQTAYKKLKDYAVNHQILLENTYYCVLLEVYDDYLIDLYVPIKKMEE
>NZ_CP012712.1|WP_167542249.1|2191083_2191242_+|hypothetical-protein
MVVENHRIAYRNVASKIYQFYPEEIHVAITDFDEILRNHGYHSNGNTFFCHS
>NZ_CP012712.1|WP_157777078.1|2191180_2191543_+|DUF5085-family-protein
MRFCATMVITRMEIRFFAILSDPTDEIMVAEIFLSIAEDHFQVPEDENIFFRSYFSIYPMIMTRIVQHIEEQSQVKYWELIEYMNNHNLKQRTPVFVGFKATKSGKIYAEMSVGIESPLS
>NZ_CP012712.1|WP_003251156.1|2191746_2192646_+|ABC-transporter-ATP-binding-protein
MKVVDIKNLTKTYKKNRGIIDLTFSIEEGEIFGFIGPNGAGKSTTIRTLLNFIYPTSGSATIFGKDIIKHSKEIRQHVGYLPSEVHYYDDMKVIDLLKYSAGFYKKFNSKRMKELAERLDLDLHKKIEDLSFGNRKKVGIVQALLHEPKLLILDEPTGGLDPLMQNTFFELLAEERKKGTTIFFSSHILSEVQKMCDRVAIIKEGKLVKVETIENLTKKNLRYITIAFEQQAEQINFELEGIVKKEVNGNEMTLLYSGDIKALLNRLNALPMKDLLIEEPTLEEVFMHYYEKGGVDNDF
>NZ_CP012712.1|WP_003251153.1|2192635_2193433_+|ABC-transporter-permease
MIFKRELKRNLKSLIIWSIVLSGLILLTLSIYPQFAEQQKEMTKLLESYPESIKKVFGMNELNMGDLLGFYGVEIYMMTTLLGSIYAAILASNILAKEENEKTIEFLLSKPVSRSRIVTEKLLAVLVNILIFNGVSAAASIIGFQFAKDPDVPADTFSLLIVATILLHLTFGAIAFLLSALMRKTRNILSISLGVVLAAYFMNVMAGISEDLEFLKYFSPFKYVDAAAIINDNEIKPLYIFIMAAVILVSIFTSYMVYRKKDIAV
>NZ_CP012712.1|WP_042385576.1|2193432_2194110_+|TetR/AcrR-family-transcriptional-regulator
MKLEVLTLYPAFEKQPQEKKDLIIKVAIEEFVKNGYEKASTDVITRRAGISKGILFHYFKSKKNLYLYLVNYVKDFLTEIAMTKLKKIQSDDFFERIKEIVLLKQEIMIQYLQETQFITDAFLNPPVAVKAEMEKIIKEYYEAYQEDFLLEHVYIKELIQTEKLREDISADTVIRMTMCIVDQLSNKYLALYKIKQIDIMDTTEFMLRELNEYLKIVKYGIYKPE
>NZ_CP012712.1|WP_042385573.1|2194709_2195114_+|phage-holin-family-protein
MERLDVAFKTGAATIGGMVVFFFGGWMIPLRILVSLSIVDYVSGLIAGAVEKKLSSKVGFKIAKKVMMFTLVATGNLVDIAIGKGHVFRDAVIFFYMGNEILSILESAGRIGLPIPEQLRSAIEILKGKEKRQR
>NZ_CP012712.1|WP_042385570.1|2195547_2196015_-|Lrp/AsnC-family-transcriptional-regulator
MKIGEIDLKIIAELKKNSRLSMRELGRKVNLSPPSVTERVKRLEDSGVIEGYTIQVNRKKLGFTIDCIIEVTIKNGEHKRFKEFIEQYPTALSCYRIAGRACYMVMLTVSRLEEIEEFINDISTFATTLTHIIFSEVKIKNNLEAHTPLLRSDEK
>NZ_CP012712.1|WP_042385589.1|2197462_2198485_+|amidohydrolase
MIKTSNGEEIFIIDAHIALWDGSKENQLNIHGEQFISCFYDYHKNLSPKEYWWPKNEFVKYSPEKLVNDVFIEGCVDMAIFQPVLLKEFYKNGFGNFEANEELAKKYPSRFICNGTFDPRHGERGLEQLEENKEKYNWQGVKLYTADWYGNSKGYKLSDDWSKRYLEKCQELGIRNIHIHKGPTITPLNRDAFDVADVDDAASCFPELNFIVEHVGLPRLEDFCWIATQEKNVYAGLAVAIALIHTRPRYFAQIISELLYWLDEDRIIFGSDYAIWEPKWIIEKFLEFELPEDIQEETGVTLDLEVKKKILAGNVARLYNIDIEKQKEKLKNCKLYKYTA
>NZ_CP012712.1|WP_042385588.1|2198554_2199265_+|iron-sulfur-cluster-assembly-protein
MDKEKQVYSMLEKVYDPELDQPLTELGFIDHIVIKDNHVEVVIRLPTYWCSPNFAYIMAEDIKKYVSELEWVKTVQIHLLDHCTSDEISRGASAGKSFSEVFGALSDGDLEELRKTFDIKAYYARQEKLIKYLLNRGMTKKEINSLSLQELNELPLPEEGKLLREKYLEKKKVLNHSSTFAITTPEGKPLSEEEFSDYLQGAKLTRLSMEFNAHYCRGLLEARYNLSAAHEGSLAK

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Crispr_ID: NZ_CP012712_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012712_7

2529953-2532187

TypeIII

Consensus_repeat	Method
GGTTTTATCTTACCTATAAGGAATTGAAAC	CRISPRCasFinder
GGTTTTATCTTACCTATAAGGAATTGAAAC	CRT
TTTTATCTTACCTATAAGGAATTGAAAC	PILER-CR

33 spacers

csm6,csx1,cmr1gr7,cas10

The CRISPR arrays of NZ_CP012712_7

>merge|NZ_CP012712|7|2529953-2532187|CRISPRCasFinder,CRT,PILER-CR
GGTTTTATCTTACCTATAAGGAATTGAAACCTCAACGATGAAGAATCCATACTATAATATCTGCAGATAGGTTTTATCTTACCTATAAGGAATTGAAACTTGTGTGAAGTTCTTTTTCTTCCCCTGTTGTTGAATGGTTTTATCTTACCTATAAGGAATTGAAACTCGTACCATTCGACTTTGGTGTATTCGTTGTTGTCGGTTTTATCTTACCTATAAGGAATTGAAACATGCGAGAAACAAATCACTTTCTCCAAACAAAAAAGGTTTTATCTTACCTATAAGGAATTGAAACTCTTTCCACGCTAATGATAAAAACCAAGCCATGATGGTTTTATCTTACCTATAAGGAATTGAAACATGGCCTTCACTGCGGAACGCGGCAATTCGAACCGTGGTTTTATCTTACCTATAAGGAATTGAAACAATGAAAGAAAACAAAGAAAAAGTCATTGACGTTTCTGGTTTTATCTTACCTATAAGGAATTGAAACGAGTCTTTAGTTAGGACGTTTTCTGATTCGGAAACGGTTTTATCTTACCTATAAGGAATTGAAACCGCTACATATCTATCGAAAGGAGGGACGAGTATGGCACGGTTTTATCTTACCTATAAGGAATTGAAACTGGAAAAGGAAGTCGGGCATTGGAAAGAGCTTTTCGAAGGTTTTATCTTACCTATAAGGAATTGAAACTTGGATATCCATACTTTTCTATCATGGCATGCTTCGGGTTTTATCTTACCTATAAGGAATTGAAACAGAACACCAGCAATAAATGATTCCCCCGGCGAACAAGGTTTTATCTTACCTATAAGGAATTGAAACAAGCTGGCAGCGTTCGGCAGGCGCTCCGCCTGTCGAGGGGTTTTATCTTACCTATAAGGAATTGAAACCGTCGAATTCGAATTTTTCGCCGTAAAAGTCTGTGCCGGTTTTATCTTACCTATAAGGAATTGAAACAAAGGTGGCCAAGGTGTTTTGAAGCGCGGCACCGTGGGTTTTATCTTACCTATAAGGAATTGAAACACAAAGAGCTTGAAAAAATTCCGGTCCGCATCGACGAGGTTTTATCTTACCTATAAGGAATTGAAACTTTTCTTCTCGGAGCCTTTTCTTTGCGAGCCGTATTGGGTTTTATCTTACCTATAAGGAATTGAAACCACGATGAAACCACTAGGAATTGTCCGCAAAATCGACGGTTTTATCTTACCTATAAGGAATTGAAACATCGGTCTAACCGATAAACTAGTACAATATCGATAGTTTTTATCTTACCTATAAGGAATTGAAACGAACTGTATGCTATATCTTTTTCAATATGGCTGAACAGTTTTTATCTTACCTATAAGGAATTGAAACAATGCCCCGACTTGCACGCGATAAACCTTCCCTTGTGTGTTTTTATCTTACCTATAAGGAATTGAAACTGTAGGGAAAGCCAGTGGATGGATCGCGTCTATTTGTTTTTATCTTACCTATAAGGAATTGAAACAACAAGTAAATATGAATGAACACCAAGCTGCAGCTCTTGTTTTTATCTTACCTATAAGGAATTGAAACACGATAGAATCATGCTTCTATCTAATGAAATGATATTTTGGTTTTATCTTACCTATAAGGAATTGAAACACATTTGCAAGGTGGGAAAATGAAGAAAAGTATAAGGGTTTTATCTTACCTATAAGGAATTGAAACGAGCCGAGTCGCCGCGTTAGTTTGGGGTTGAGCTAATGGTTTTATCTTACCTATAAGGAATTGAAACGGCATCTCCCTCGAGGAACTAGCCGCCGCAACTGAAGGGTTTTATCTTACCTATAAGGAATTGAAACTGGAAGAAAAAGATTTCGAAAATAAAAATAAATAAGGGCGGTTTTATCTTACCTATAAGGAATTGAAACAATGGCTAGCGGTCGGGAAGCGTGCCGGCCTTTCTTTGGTTTTATCTTACCTATAAGGAATTGAAACCTCACACCCTACCAACACCTTATCCACAAACTTATCCGTTTTATCTTACCTATAAGGAATTGAAACATATATCGAACCTTCACCAACATAGCTCGCTGCGTTGTAGTTTTATCTTACCTATAAGGAATTGAAACTCGGCTTGCCATCATCAGCGCGTAGGTCGCCATCCCACGTTGTATCTTACCTATAAGGAATTGAAACGAAGTAATCTTGAAAACAGCAGCACAGGCTGCCTTGGAGTTTTTATCTTACCTATAAGAAATTAAAGC

>NZ_CP012712|7|7|2529953-2532187|CRISPRCasFinder
GGTTTTATCTTACCTATAAGGAATTGAAAC	CTCAACGATGAAGAATCCATACTATAATATCTGCAGATA
GGTTTTATCTTACCTATAAGGAATTGAAAC	TTGTGTGAAGTTCTTTTTCTTCCCCTGTTGTTGAAT
GGTTTTATCTTACCTATAAGGAATTGAAAC	TCGTACCATTCGACTTTGGTGTATTCGTTGTTGTC
GGTTTTATCTTACCTATAAGGAATTGAAAC	ATGCGAGAAACAAATCACTTTCTCCAAACAAAAAA
GGTTTTATCTTACCTATAAGGAATTGAAAC	TCTTTCCACGCTAATGATAAAAACCAAGCCATGAT
GGTTTTATCTTACCTATAAGGAATTGAAAC	ATGGCCTTCACTGCGGAACGCGGCAATTCGAACCGT
GGTTTTATCTTACCTATAAGGAATTGAAAC	AATGAAAGAAAACAAAGAAAAAGTCATTGACGTTTCT
GGTTTTATCTTACCTATAAGGAATTGAAAC	GAGTCTTTAGTTAGGACGTTTTCTGATTCGGAAAC
GGTTTTATCTTACCTATAAGGAATTGAAAC	CGCTACATATCTATCGAAAGGAGGGACGAGTATGGCAC
GGTTTTATCTTACCTATAAGGAATTGAAAC	TGGAAAAGGAAGTCGGGCATTGGAAAGAGCTTTTCGAA
GGTTTTATCTTACCTATAAGGAATTGAAAC	TTGGATATCCATACTTTTCTATCATGGCATGCTTCG
GGTTTTATCTTACCTATAAGGAATTGAAAC	AGAACACCAGCAATAAATGATTCCCCCGGCGAACAA
GGTTTTATCTTACCTATAAGGAATTGAAAC	AAGCTGGCAGCGTTCGGCAGGCGCTCCGCCTGTCGAGG
GGTTTTATCTTACCTATAAGGAATTGAAAC	CGTCGAATTCGAATTTTTCGCCGTAAAAGTCTGTGCC
GGTTTTATCTTACCTATAAGGAATTGAAAC	AAAGGTGGCCAAGGTGTTTTGAAGCGCGGCACCGTG
GGTTTTATCTTACCTATAAGGAATTGAAAC	ACAAAGAGCTTGAAAAAATTCCGGTCCGCATCGACGA
GGTTTTATCTTACCTATAAGGAATTGAAAC	TTTTCTTCTCGGAGCCTTTTCTTTGCGAGCCGTATTG
GGTTTTATCTTACCTATAAGGAATTGAAAC	CACGATGAAACCACTAGGAATTGTCCGCAAAATCGAC
GGTTTTATCTTACCTATAAGGAATTGAAAC	ATCGGTCTAACCGATAAACTAGTACAATATCGATA
GTTTTTATCTTACCTATAAGGAATTGAAAC	GAACTGTATGCTATATCTTTTTCAATATGGCTGAACA
GTTTTTATCTTACCTATAAGGAATTGAAAC	AATGCCCCGACTTGCACGCGATAAACCTTCCCTTGTGT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TGTAGGGAAAGCCAGTGGATGGATCGCGTCTATTT
GTTTTTATCTTACCTATAAGGAATTGAAAC	AACAAGTAAATATGAATGAACACCAAGCTGCAGCTCTT
GTTTTTATCTTACCTATAAGGAATTGAAAC	ACGATAGAATCATGCTTCTATCTAATGAAATGATATTTT
GGTTTTATCTTACCTATAAGGAATTGAAAC	ACATTTGCAAGGTGGGAAAATGAAGAAAAGTATAAG
GGTTTTATCTTACCTATAAGGAATTGAAAC	GAGCCGAGTCGCCGCGTTAGTTTGGGGTTGAGCTAAT
GGTTTTATCTTACCTATAAGGAATTGAAAC	GGCATCTCCCTCGAGGAACTAGCCGCCGCAACTGAAG
GGTTTTATCTTACCTATAAGGAATTGAAAC	TGGAAGAAAAAGATTTCGAAAATAAAAATAAATAAGGGC
GGTTTTATCTTACCTATAAGGAATTGAAAC	AATGGCTAGCGGTCGGGAAGCGTGCCGGCCTTTCTTT
GGTTTTATCTTACCTATAAGGAATTGAAAC	CTCACACCCTACCAACACCTTATCCACAAACTTATC
CGTTTTATCTTACCTATAAGGAATTGAAAC	ATATATCGAACCTTCACCAACATAGCTCGCTGCGTTGT
AGTTTTATCTTACCTATAAGGAATTGAAAC	TCGGCTTGCCATCATCAGCGCGTAGGTCGCCATCCCA
CGTTGTATCTTACCTATAAGGAATTGAAAC	GAAGTAATCTTGAAAACAGCAGCACAGGCTGCCTTGGA
GTTTTTATCTTACCTATAAGAAATTAAAGC

>NZ_CP012712|7|4|2529953-2532187|CRT
GGTTTTATCTTACCTATAAGGAATTGAAAC	CTCAACGATGAAGAATCCATACTATAATATCTGCAGATA
GGTTTTATCTTACCTATAAGGAATTGAAAC	TTGTGTGAAGTTCTTTTTCTTCCCCTGTTGTTGAAT
GGTTTTATCTTACCTATAAGGAATTGAAAC	TCGTACCATTCGACTTTGGTGTATTCGTTGTTGTC
GGTTTTATCTTACCTATAAGGAATTGAAAC	ATGCGAGAAACAAATCACTTTCTCCAAACAAAAAA
GGTTTTATCTTACCTATAAGGAATTGAAAC	TCTTTCCACGCTAATGATAAAAACCAAGCCATGAT
GGTTTTATCTTACCTATAAGGAATTGAAAC	ATGGCCTTCACTGCGGAACGCGGCAATTCGAACCGT
GGTTTTATCTTACCTATAAGGAATTGAAAC	AATGAAAGAAAACAAAGAAAAAGTCATTGACGTTTCT
GGTTTTATCTTACCTATAAGGAATTGAAAC	GAGTCTTTAGTTAGGACGTTTTCTGATTCGGAAAC
GGTTTTATCTTACCTATAAGGAATTGAAAC	CGCTACATATCTATCGAAAGGAGGGACGAGTATGGCAC
GGTTTTATCTTACCTATAAGGAATTGAAAC	TGGAAAAGGAAGTCGGGCATTGGAAAGAGCTTTTCGAA
GGTTTTATCTTACCTATAAGGAATTGAAAC	TTGGATATCCATACTTTTCTATCATGGCATGCTTCG
GGTTTTATCTTACCTATAAGGAATTGAAAC	AGAACACCAGCAATAAATGATTCCCCCGGCGAACAA
GGTTTTATCTTACCTATAAGGAATTGAAAC	AAGCTGGCAGCGTTCGGCAGGCGCTCCGCCTGTCGAGG
GGTTTTATCTTACCTATAAGGAATTGAAAC	CGTCGAATTCGAATTTTTCGCCGTAAAAGTCTGTGCC
GGTTTTATCTTACCTATAAGGAATTGAAAC	AAAGGTGGCCAAGGTGTTTTGAAGCGCGGCACCGTG
GGTTTTATCTTACCTATAAGGAATTGAAAC	ACAAAGAGCTTGAAAAAATTCCGGTCCGCATCGACGA
GGTTTTATCTTACCTATAAGGAATTGAAAC	TTTTCTTCTCGGAGCCTTTTCTTTGCGAGCCGTATTG
GGTTTTATCTTACCTATAAGGAATTGAAAC	CACGATGAAACCACTAGGAATTGTCCGCAAAATCGAC
GGTTTTATCTTACCTATAAGGAATTGAAAC	ATCGGTCTAACCGATAAACTAGTACAATATCGATA
GTTTTTATCTTACCTATAAGGAATTGAAAC	GAACTGTATGCTATATCTTTTTCAATATGGCTGAACA
GTTTTTATCTTACCTATAAGGAATTGAAAC	AATGCCCCGACTTGCACGCGATAAACCTTCCCTTGTGT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TGTAGGGAAAGCCAGTGGATGGATCGCGTCTATTT
GTTTTTATCTTACCTATAAGGAATTGAAAC	AACAAGTAAATATGAATGAACACCAAGCTGCAGCTCTT
GTTTTTATCTTACCTATAAGGAATTGAAAC	ACGATAGAATCATGCTTCTATCTAATGAAATGATATTTT
GGTTTTATCTTACCTATAAGGAATTGAAAC	ACATTTGCAAGGTGGGAAAATGAAGAAAAGTATAAG
GGTTTTATCTTACCTATAAGGAATTGAAAC	GAGCCGAGTCGCCGCGTTAGTTTGGGGTTGAGCTAAT
GGTTTTATCTTACCTATAAGGAATTGAAAC	GGCATCTCCCTCGAGGAACTAGCCGCCGCAACTGAAG
GGTTTTATCTTACCTATAAGGAATTGAAAC	TGGAAGAAAAAGATTTCGAAAATAAAAATAAATAAGGGC
GGTTTTATCTTACCTATAAGGAATTGAAAC	AATGGCTAGCGGTCGGGAAGCGTGCCGGCCTTTCTTT
GGTTTTATCTTACCTATAAGGAATTGAAAC	CTCACACCCTACCAACACCTTATCCACAAACTTATC
CGTTTTATCTTACCTATAAGGAATTGAAAC	ATATATCGAACCTTCACCAACATAGCTCGCTGCGTTGT
AGTTTTATCTTACCTATAAGGAATTGAAAC	TCGGCTTGCCATCATCAGCGCGTAGGTCGCCATCCCA
CGTTGTATCTTACCTATAAGGAATTGAAAC	GAAGTAATCTTGAAAACAGCAGCACAGGCTGCCTTGGA
GTTTTTATCTTACCTATAAGAAATTAAAGC

>NZ_CP012712|7|4|2529955-2532119|PILER-CR
TTTTATCTTACCTATAAGGAATTGAAAC	CTCAACGATGAAGAATCCATACTATAATATCTGCAGATAGG
TTTTATCTTACCTATAAGGAATTGAAAC	TTGTGTGAAGTTCTTTTTCTTCCCCTGTTGTTGAATGG
TTTTATCTTACCTATAAGGAATTGAAAC	TCGTACCATTCGACTTTGGTGTATTCGTTGTTGTCGG
TTTTATCTTACCTATAAGGAATTGAAAC	ATGCGAGAAACAAATCACTTTCTCCAAACAAAAAAGG
TTTTATCTTACCTATAAGGAATTGAAAC	TCTTTCCACGCTAATGATAAAAACCAAGCCATGATGG
TTTTATCTTACCTATAAGGAATTGAAAC	ATGGCCTTCACTGCGGAACGCGGCAATTCGAACCGTGG
TTTTATCTTACCTATAAGGAATTGAAAC	AATGAAAGAAAACAAAGAAAAAGTCATTGACGTTTCTGG
TTTTATCTTACCTATAAGGAATTGAAAC	GAGTCTTTAGTTAGGACGTTTTCTGATTCGGAAACGG
TTTTATCTTACCTATAAGGAATTGAAAC	CGCTACATATCTATCGAAAGGAGGGACGAGTATGGCACGG
TTTTATCTTACCTATAAGGAATTGAAAC	TGGAAAAGGAAGTCGGGCATTGGAAAGAGCTTTTCGAAGG
TTTTATCTTACCTATAAGGAATTGAAAC	TTGGATATCCATACTTTTCTATCATGGCATGCTTCGGG
TTTTATCTTACCTATAAGGAATTGAAAC	AGAACACCAGCAATAAATGATTCCCCCGGCGAACAAGG
TTTTATCTTACCTATAAGGAATTGAAAC	AAGCTGGCAGCGTTCGGCAGGCGCTCCGCCTGTCGAGGGG
TTTTATCTTACCTATAAGGAATTGAAAC	CGTCGAATTCGAATTTTTCGCCGTAAAAGTCTGTGCCGG
TTTTATCTTACCTATAAGGAATTGAAAC	AAAGGTGGCCAAGGTGTTTTGAAGCGCGGCACCGTGGG
TTTTATCTTACCTATAAGGAATTGAAAC	ACAAAGAGCTTGAAAAAATTCCGGTCCGCATCGACGAGG
TTTTATCTTACCTATAAGGAATTGAAAC	TTTTCTTCTCGGAGCCTTTTCTTTGCGAGCCGTATTGGG
TTTTATCTTACCTATAAGGAATTGAAAC	CACGATGAAACCACTAGGAATTGTCCGCAAAATCGACGG
TTTTATCTTACCTATAAGGAATTGAAAC	ATCGGTCTAACCGATAAACTAGTACAATATCGATAGT
TTTTATCTTACCTATAAGGAATTGAAAC	GAACTGTATGCTATATCTTTTTCAATATGGCTGAACAGT
TTTTATCTTACCTATAAGGAATTGAAAC	AATGCCCCGACTTGCACGCGATAAACCTTCCCTTGTGTGT
TTTTATCTTACCTATAAGGAATTGAAAC	TGTAGGGAAAGCCAGTGGATGGATCGCGTCTATTTGT
TTTTATCTTACCTATAAGGAATTGAAAC	AACAAGTAAATATGAATGAACACCAAGCTGCAGCTCTTGT
TTTTATCTTACCTATAAGGAATTGAAAC	ACGATAGAATCATGCTTCTATCTAATGAAATGATATTTTGG
TTTTATCTTACCTATAAGGAATTGAAAC	ACATTTGCAAGGTGGGAAAATGAAGAAAAGTATAAGGG
TTTTATCTTACCTATAAGGAATTGAAAC	GAGCCGAGTCGCCGCGTTAGTTTGGGGTTGAGCTAATGG
TTTTATCTTACCTATAAGGAATTGAAAC	GGCATCTCCCTCGAGGAACTAGCCGCCGCAACTGAAGGG
TTTTATCTTACCTATAAGGAATTGAAAC	TGGAAGAAAAAGATTTCGAAAATAAAAATAAATAAGGGCGG
TTTTATCTTACCTATAAGGAATTGAAAC	AATGGCTAGCGGTCGGGAAGCGTGCCGGCCTTTCTTTGG
TTTTATCTTACCTATAAGGAATTGAAAC	CTCACACCCTACCAACACCTTATCCACAAACTTATCCG
TTTTATCTTACCTATAAGGAATTGAAAC	ATATATCGAACCTTCACCAACATAGCTCGCTGCGTTGTAG
TTTTATCTTACCTATAAGGAATTGAAAC	TCGGCTTGCCATCATCAGCGCGTAGGTCGCCATCCCACG
TTGTATCTTACCTATAAGGAATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012712.1\|WP_042385326.1\|2545511_2546825_+\|TIGR02221-family-CRISPR-associated-protein	csx1	cd09732_csx1_CAS-III	gnl\|CDD\|378186
NZ_CP012712.1\|WP_155267350.1\|2532765_2533002_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224513
NZ_CP012712.1\|WP_013400887.1\|2521733_2522015_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_003250633.1\|2515903_2517121_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340849
NZ_CP012712.1\|WP_042385323.1\|2544306_2545506_+\|CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
NZ_CP012712.1\|WP_013876957.1\|2524903_2525869_-\|anti-sigma-factor-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|372728
NZ_CP012712.1\|WP_013876950.1\|2546850_2547756_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	cd09657_cmr1gr7_CAS-III-C	gnl\|CDD\|187788
NZ_CP012712.1\|WP_013400889.1\|2518189_2519614_+\|phosphomannomutase/phosphoglucomutase	unknown	unknown	gnl\|CDD\|100091
NZ_CP012712.1\|WP_042384899.1\|2517101_2518193_+\|glycosyl-transferase	unknown	unknown	unknown
NZ_CP012712.1\|WP_013876949.1\|2547752_2549399_+\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
NZ_CP012712.1\|WP_003250613.1\|2525852_2526365_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274361
NZ_CP012712.1\|WP_013400931.1\|2528363_2529599_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NZ_CP012712.1\|WP_042384901.1\|2520622_2521264_-\|DUF2238-domain-containing-protein	unknown	unknown	gnl\|CDD\|378345
NZ_CP012712.1\|WP_042385318.1\|2535071_2536529_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP012712.1\|WP_013399800.1\|2522293_2523844_+\|IS1182-family-transposase	unknown	unknown	gnl\|CDD\|226192
NZ_CP012712.1\|WP_003250604.1\|2533975_2535070_+\|CotS-family-spore-coat-protein	unknown	unknown	gnl\|CDD\|131952
NZ_CP012712.1\|WP_013400886.1\|2524081_2524726_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_042385319.1\|2537061_2538393_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NZ_CP012712.1\|WP_155267349.1\|2532417_2532702_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224513
NZ_CP012712.1\|WP_003250597.1\|2538532_2539516_+\|NAD-dependent-epimerase	unknown	unknown	gnl\|CDD\|187563

Protein	Function_ID	Function_description	E-value
NZ_CP012712.1\|WP_042385326.1\|2545511_2546825_+\|TIGR02221-family-CRISPR-associated-protein	gnl\|CDD\|378186	pfam09455, Cas_DxTHG, CRISPR-associated (Cas) DxTHG family. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.	1.25868e-70
NZ_CP012712.1\|WP_155267350.1\|2532765_2533002_+\|hypothetical-protein	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	2.69556e-10
NZ_CP012712.1\|WP_003250597.1\|2538532_2539516_+\|NAD-dependent-epimerase	gnl\|CDD\|187563	cd05253, UDP_GE_SDE_e, UDP glucuronic acid epimerase, extended (e) SDRs. This subgroup contains UDP-D-glucuronic acid 4-epimerase, an extended SDR, which catalyzes the conversion of UDP-alpha-D-glucuronic acid to UDP-alpha-D-galacturonic acid. This group has the SDR's canonical catalytic tetrad and the TGxxGxxG NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NZ_CP012712.1\|WP_003250633.1\|2515903_2517121_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340849	cd03822, GT4_mannosyltransferase-like, mannosyltransferases of glycosyltransferase family 4 and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.	4.58495e-98
NZ_CP012712.1\|WP_013876949.1\|2547752_2549399_+\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	3.13284e-93
NZ_CP012712.1\|WP_042385323.1\|2544306_2545506_+\|CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	3.03838e-10
NZ_CP012712.1\|WP_013876957.1\|2524903_2525869_-\|anti-sigma-factor-C-terminal-domain-containing-protein	gnl\|CDD\|372728	pfam13791, Sigma_reg_C, Sigma factor regulator C-terminal. This family is the C-terminal domain of a sigma factor regulator, this may represent a sensory domain.	1.76867e-20
NZ_CP012712.1\|WP_013876950.1\|2546850_2547756_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	gnl\|CDD\|187788	cd09657, Cmr1_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	8.14003e-12
NZ_CP012712.1\|WP_042385318.1\|2535071_2536529_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	4.03275e-71
NZ_CP012712.1\|WP_013400889.1\|2518189_2519614_+\|phosphomannomutase/phosphoglucomutase	gnl\|CDD\|100091	cd03089, PMM_PGM, The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a bisphosphorylated sugar intermediate. The reaction involves two phosphoryl transfers, with an intervening 180 degree reorientation of the reaction intermediate during catalysis. Reorientation of the intermediate occurs without dissociation from the active site of the enzyme and is thus, a simple example of processivity, as defined by multiple rounds of catalysis without release of substrate. Glucose-6-phosphate and glucose-1-phosphate are known to be utilized for energy metabolism and cell surface construction, respectively. PMM/PGM belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the phosphoglucomutases (PGM1 and PGM2). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_CP012712.1\|WP_003250613.1\|2525852_2526365_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|274361	TIGR02950, RNA_polymerase_ECF-type_sigma_factor, RNA polymerase sigma factor, SigM family. This family of RNA polymerase sigma factors is a member of the Sigma-70 subfamily (TIGR02937) and is restricted to certain lineages of the order Bacillales. This family encompasses at least two distinct sigma factors as two proteins are found in each of B. anthracis, B. subtilis subsp. subtilis str. 168, and B. lichiniformis (although these are not apparently the same two in each). One of these is designated as SigM in B. subtilis (Swiss_Prot: SIGM_BACSU) and is activated by various stressors.	4.33334e-21
NZ_CP012712.1\|WP_013400931.1\|2528363_2529599_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	1.74074e-156
NZ_CP012712.1\|WP_042384901.1\|2520622_2521264_-\|DUF2238-domain-containing-protein	gnl\|CDD\|378345	pfam09997, DUF2238, Predicted membrane protein (DUF2238). This domain, found in various hypothetical bacterial proteins, has no known function.	1.96264e-60
NZ_CP012712.1\|WP_013399800.1\|2522293_2523844_+\|IS1182-family-transposase	gnl\|CDD\|226192	COG3666, COG3666, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.62493e-31
NZ_CP012712.1\|WP_003250604.1\|2533975_2535070_+\|CotS-family-spore-coat-protein	gnl\|CDD\|131952	TIGR02906, Spore_coat_protein_S, spore coat protein, CotS family. Members of this family include the spore coat proteins CotS and YtaA from Bacillus subtilis and, from other endospore-forming bacteria, homologs that are more closely related to these two than to the spore coat proteins YutH and YsxE. The CotS family is more broadly distributed than YutH or YsxE, but still is not universal among spore-formers. [Cellular processes, Sporulation and germination].	3.10075e-110
NZ_CP012712.1\|WP_042385319.1\|2537061_2538393_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NZ_CP012712.1\|WP_155267349.1\|2532417_2532702_+\|hypothetical-protein	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	1.13126e-11

>NZ_CP012712.1|WP_013400931.1|2528363_2529599_+|IS256-family-transposase
MAQYHITLNDELLHGLFTRDEGLAKLLEQVLNQILEAQVEEQLGARRYERTEERKGYRNGSYPRQLTTRVGRLTLRVPRTRDGEFSTELFQRYQRSEQALVLALMEMVVNGVSTRKITQITEELCGTSFSKSTVSSLCKGLDPIIQDWNYRSLHEHVYPFVLVDAIYTKVREDGRVRSRAVLIATGVNEEGYREILGLQIGNSESESSWSEFFGWLKDRGLRGVDLIISDQHGGLVQAIEKHFQGATWQRCQTHFIRNILDAAPKYMQDALLEEIRGILHAPNKQTARLLLEQVLAKWEEKAPKAMQILEEGFEDATAVLDYPDRYRRRLRTTNGVERLNEEIRRRERVIRIFPNRESVYRLVGAVLIEIDEKWMSGRKYLDMAEYWKWRKTKEQGVRSVNQEAPAIKRVG
>NZ_CP012712.1|WP_003250613.1|2525852_2526365_-|RNA-polymerase-sigma-factor
MNDFELGEKLHEQLERVKVYLLKMGASLQDAEDITQETAYKFLTYIDSVNIENVESWLFRVSVNQYYDLCRKHNRQKNISLKFNYKELFEEFTPEKAVLQKEFEKDIYILLDRLKPKYAQFLILKYSIGLKLTEIAALYDMKVDSVKTIIHRARKQFIEEYRRHQNERRE
>NZ_CP012712.1|WP_013876957.1|2524903_2525869_-|anti-sigma-factor-C-terminal-domain-containing-protein
MNEENEFLPQDPDFRKLVKKAKRNSALRIVVISLIISIIVVIAFYFVGNSIMINKVNEEVRNDAIWHSIHGANIEEQGTSINYSLFSATSKTEFIKKVNGIPVPWVPVEKEYSIFGQSKIIISKGASGTGNVDEKRIPMYFNGERVIEFIHPKVNSSLFDDRSIVSSMDDDKVIELALSFDKGYKVTDVQKIFNKNISWFWVDTYSESDIKNYNNFIKETGKDFTIIGDDAIGFHYINQPESKWGAEYFIRSLKELKQNGSYKDVADKIIQNITHSNKEKLSAENLEIIGVVITGTPSEIEKFNNVPFVRAASLGVTADRY
>NZ_CP012712.1|WP_013400886.1|2524081_2524726_-|hypothetical-protein
MKKIIKIGIGVFGIVAFGIGLLIFVFLQSMKADEDEVKKVKIQAQGYIKNTFKDEIVIYDTLFDNMGNFPTFDYAAKAENKKDNTQFLIYYNEETKQMEDTYIAEKWEKELENNIRPYIEQKLGTLDEFWVEYDERAGITYNVNPNKPSSYKEYDAAPTILISVPRKPDKKDEEILNEIVAFLQKDVGLKHGTVSMSYIKNGAPLDDKEWFKTF
>NZ_CP012712.1|WP_013399800.1|2522293_2523844_+|IS1182-family-transposase
MYIYYNRDQLILPMDLEILIPKHHLCRIVDLAVEKMDPALLVSLYPGGGRPAYHPKMMLKVILYAYANRIYSSRQIAKQLKENIYFMWLSGHQTPDFRTINRFRSERMKDIIYETFFSIVDLLRQEGLVKLEDYFLDGTKIEASANKYTFVWRKSTEKYDQKLEEKFRKIVASIEQVVKEDEESEQEGDFQEKLEASPITSEKIEAVIEQVEEHLKKEPKNRTLKKAKQQLEQDILPRKKKYEEYKKVLGERNSFSKTDPDATFMRMKDDHMKNGQLKPGYNVQIGTENQFITGFSVHQRAGDAGCFIPHLEQLAAYGRPMPKRAIADSAYGSEENYTYCEKKQIVALIKYNTLDREQTKAWAKEIGRIENMTYDEELDEWICAKGERLVFVYKRKETTDNGYVIVKRTYRCTACAGCPFQAACAKGKDTKTIRVSLKNQQQRQEIRKRLSTEEGATTYRRRQIENEPVFGQIKHNQQFHRFSLRGLPKITLEWGLVCAAHNLRKWATTTDPTRKK
>NZ_CP012712.1|WP_013400887.1|2521733_2522015_+|hypothetical-protein
MKNIMPKLSLTVIIAALLFFFMSFFMAVFLGLIIPAPIIRIIINLGIIVSFVLALLSPKGKWKNAALTVVIIIGLLYLIGIELMGFLFRGNGF
>NZ_CP012712.1|WP_042384901.1|2520622_2521264_-|DUF2238-domain-containing-protein
MKHDGSRKIHLFLLLVIIAVFIWSAIKPASYLTWALEVSPAVVGLIIVITIYYRFRFTTLSYVIMAVLAILMFIGGHYIYSKVPLFDWIKDTYDLKRNHYDRFGHLLKGLFAIVLREILLRKTPLTKGTWLFAIVVSMSLAIAALYEIIEWLVSKISKGGEASKNFLGIQGDIWDTQWDMLYSLTGSIVALLIFSKLHDKLLKKEIRTSNAQH
>NZ_CP012712.1|WP_013400889.1|2518189_2519614_+|phosphomannomutase/phosphoglucomutase
MNFSMAQQQFVLPTHVFKEYDIRGRAGEELDENFAYLLGLAFAEMVRQAGEQKVVVGHDNRISSPTLHRALIAGLSQASCQVIDIGLVTTPMFYYSLEYTNVPCGIIVTASHNPGDENGFKIAMNKTTIYGERIQELRRIMERLQTQGVNRSDSWKEGYVEKLDIKPAYLEMLENKIKLGARKLKVVVDCGNGTASIIAPKALEAWGCEVVPLYCESDPTFPNHHPDPVVPENLQDLIDTVRREKADVGLAFDGDGDRLGVVDEEGNIRWGDQLMILFWREILRRYPGADAPVEVKCSQALVEEIERLGGKPFFHRTGHSHIKATLRSRPEIPFAGEMSGHLFFNDEFYGYDDALYAAGRLLRILSSDDRKLSQLFADVPSYHATPETRVPCPEEKKAEAIAAVKQRFADSHEVVDVDGARIQFKDGWGLVRPSNTQPILVLRAEAASPEALADIKQQLADVLSKPPLNLNITW
>NZ_CP012712.1|WP_042384899.1|2517101_2518193_+|glycosyl-transferase
MSPAAVKFDHLERLTDDTGLLEHCLGRIPRRREGYTTDDNARAIWACVEWLDLLKGDESGERRRLYRLLDRYLAFLLWAQREDGTFQNNFHFDRTPEAEEHSDDCLGRSIWAAAAAYVSLDDEARRRVVAEIFRQALPASGGMQFLRGQAWGLAACCLMLSKRNNGSALPSGVAAAELANLADNFEQRLLAAYRAHRTDDWHWFEPQITYANGLLPWALFVAYRYHGRDETLQVAKESLDFLAAKMSGQNGVIRPVGNRGWCSIDRRADWDQQPVDVMKLALAAREAYRALGDETYRELVRRCRNWFYGDNDLGTPLADPSDGSCCDGLNPDGPNPNRGAESTLSYLLTEAMAQSLQLEVVSR
>NZ_CP012712.1|WP_003250633.1|2515903_2517121_+|glycosyltransferase-family-4-protein
MKRIAYVSTYPPRRCGIATFTEHLLQSVRIAGKRRDIDPVIVLYNENDDDSVYRNDPKFWPLAAEDRAAYARMAERVNHSDVSVVVLQHEFGIFGGEAGEYILDFVRALKKPLVTTFHTIFADPQPPYRHVQQQIADESDAIVVMNRQAIPYLTKAFHLPESKIFYIPHGSPVPRREERDRLRRRLGFAGRKVMFTFGLLNRGKGIESVLAALPGVIREVPETLYVIAGQTHPEVKKREGEAYREELMEMVRRLGLENNVQMINRYFSEEELVDYLTACDLYVTPYPGMQQITSGTLAYAVGVGRPVLTTPYEHARDLLRGCEELLLPYGDTEAWERQLRRLLADDAALRQWEERIWKIGEATHWPCVGAQYVQLFAQICGEKGGEETAETQLKGEVKSVVSGSR
>NZ_CP012712.1|WP_155267349.1|2532417_2532702_+|hypothetical-protein
MDYKKALERILMGKQRKIDVGRIDEEYCITVVGIGLDGKVAEVNNISKYKKWFNFIRLGALSYVLSFLQVLLKYRPVNIQLNVDGEKLVFLMSG
>NZ_CP012712.1|WP_155267350.1|2532765_2533002_+|hypothetical-protein
MMDFSTFASVHSITKRDLLRTFPKAYKGKHIFHPGVAMIKGKQVEVTSELPVIVQSDGEVLAKTPVNVTIRKDALLIV
>NZ_CP012712.1|WP_003250604.1|2533975_2535070_+|CotS-family-spore-coat-protein
MESIFIEPWEVDESTHEFFIPDYINELADKVLKHYDFSVESIQVVTTKPDKGGAIWKLETSAGPKSLKLLHRRPTRSLFSLGAQEYLVDVRHARVPPIVKTKDGTNYVEAGGKLWFVAEWIESLTPVTKDLEGAKLLCSALGEFHRLSKGYVPPPQAETASRLHKWRRNYEKIIYKMDWFRNIAKAYNELPASSYLLNVIDEFEEQARRSLERLDQSSYFELIKHGNAYWGLVHQDYGWSNGQMGRDGMWIIDLDGVAFDLPIRDLRKLISGTMADLYKWDAKWIREMIKAYHKENPISPELYEILMIDLSLPNEFYKNIKEVVYDPEMFLNEQTVQLMKTIIDTDQTKWPVLAEIQNDWKEVE
>NZ_CP012712.1|WP_042385318.1|2535071_2536529_+|glycosyltransferase-family-4-protein
MKILMICTEKLPVPPVRGGAIQTYISGVLPYLSKHHDITVLGISDPSLPDQETLDGVHYVRVPGKIFEIYREGVVRYIESNSFDLIHIFNRPRLVLPVRQAAPHAKITLSMHNDMFNIEKIDPEEATAVLEEVSSIVTVSNYVGNVIRQLYPQASPKIRTIYSGVDTERFLPGSHPKMQETRKEIRKAHGLENKTVILFAGRLSRNKGVDKLVRALPELSKKFKDLALVIVGSNWFSQNNVTDYVAYVRALAKKVPVPVVTTGFVAPDEIQNWFAAADLFVCTSQWQEPLARVHYEAMAAGLPIVTTARGGNPEVIFSEENGLVVENPEDPSNFAEKIAKILFDKSLMKKMGERGRELAVSRYKWERVASELLEVWNQAVHMTSTTAVEQDSTDKTNQTGAKELEYVIEHNSETKKEDEKAAMEQDSAEKISEDEVNNTEVEEPESVARIKIIDVDEETIRNSIWFSSTYKRGRKRNNRRGRKGS
>NZ_CP012712.1|WP_042385319.1|2537061_2538393_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MNIAMIGAGYVGTATSVAFAEYGHKVYVIERDWEKLKKLKMSVLPFFEEGMEELFKKHSANGNLLFFHYIEEVIDQCEILMITVGTPSLPNGEADLSYVEEAARQIGRSMNEYKAIVIKSTVPVGTGDKINKIIKTELKKRNKEISFDLISNPEFLREGKALQDALHPERIVIGCETEKARQVMKELYSGINSPILFTTVKDAEMIKYASNAFLATKISFINELARLCDKVGANVIQVAKGMGLDSRIGPQFLQAGIGFGGSCFPKDVKALLALASAEKTPLQILQAVLDVNETQAQWFMEKVKKALGSLSRKRIAVLGLTFKPQTDDIREASSLKIIHYLLQNNACITAYDPQGTEHVKKIYPTINYAKTTLEALNGADAALIVTEWKEIIEIDWKKAKSILSQPFVFDGRNCLDASVMLELGYHYEGVGTPNLDERINGSF
>NZ_CP012712.1|WP_003250597.1|2538532_2539516_+|NAD-dependent-epimerase
MQNNAKYIFITGCAGFIGFHLTKRLLDEGFSVLGMDDMNDYYDTSLKYDRLKIVMKHPHFRFVKGSIENIELLEKLFSQYDVDTVVNLAAQPGVRYSLKNPHKYIQANVVGFANILECCKKHKIRHLIYASSSSVYGNNKNAPFSVADRTDSPVSLYAATKKANELMAYTYSHLYRLPTTGLRFFTVYGPWGRPDMALFKFANAIVKQQPIEIYNYGNMKRDFTYVDDVTESILRLIDKGPSTESPYKIYNIGNNQPVQLNYFIEVLEEHLGKKAIKKLLPMQPGDVPETFADIDELVKDINYKPKVSIEEGIKRFVEWFKDYYKIN
>NZ_CP012712.1|WP_042385323.1|2544306_2545506_+|CRISPR-associated-protein
MYQHIVITCGISLLTGKANVFSINRDETMAEIRSLLDVKEINKEIEKKVERWLQYAKQFSHEVVHRPNHVSAEYSTVHELRKKGKLVERPTIVLFVTQTVGGRIVESILTSLLEMHFQANVRVIYVDIDVKNPKRMHETLGEYMSKLSYALSKGEPTSTCSAPIGGYKVMTSLGYIVGAFLNYPTAYLHEDHQVLHEIPPVPIHIKEEFVYEHLDLLRKCQKDVVPVQELSYQEKRCVEQYPSLFYQEDGFVCLSAFGEFLLEHEKYRHLFDTAYFVSKQILDVMEHNRHQSLFIFQQFHELVKKLKYKEGNMFELQHEKEFKTIRQKQIKYHLYKGASNGQTAFRLAYRYDEQKDRLYANYLWLDHKRYEREASQGRGLYEDWSEFFDITNDLMTVVK
>NZ_CP012712.1|WP_042385326.1|2545511_2546825_+|TIGR02221-family-CRISPR-associated-protein
MARNVLLSFLGRNDYEYCFYTYRGQRSSYTRFVQTAIYELFRNEEPMDVIIFATKEAKESNWNDKVREGQQVKGIQTAFQQIAPEATVKLVEIESGQDESANWKLFDSIIAEIGEGDTIYFDITHSFRSIPFVALIVLNYARLVKKATIGALAYGWFEKLGRPNEVKQLSPEQRLVPIVDLTNMAQLLDWTNGVDQFLRTGDASLIKELTARENRKVFCDANASPLLKREVEKLNKLAKQLDRTGNSIRTCRSLQVEEEVEKFRYQLEQVRHSQAEAIKPLVPILDEMEKKYSNFGGNTIINGWEVARWCVDNGLIQSALTMLSENVVTAICRAFQLEVTNVEIRNDLHSAIRIIIRRTKKEEWEVHSVPFVEEMVEKLLPYRELLKPFGEVAELRNDMNHAGVRERPLTADRFAQRVKTLLDAIKPFFEEMAALSQ
>NZ_CP012712.1|WP_013876950.1|2546850_2547756_+|type-III-B-CRISPR-module-RAMP-protein-Cmr1
MVDNERMKASAIVETTYKLKLITPMAMHGANAGEKAEFRISSLRGVWRYWWRTLQEEKNHTALLEQEEEWFGGTQIKKQKSPVNLLLQRSLSGLKRESILPHRTKKSFAVRTIPAGQETAVVMRTLQKHKQLLETYELYFQYMLHLAGMGQRARRGFGAVQWEGHHWETVADFVASLQEVLIRLGQSERFQFSDSGCIVKRKGEARTYHPVLSAVWVGEGQKTPQEVLKRFGVASHEANRYGRLGAVRPKRFASPLWCTVRKIGDLYYPVVTEVKADSSVYKQPQYQRDRDLFLEIAGVRV
>NZ_CP012712.1|WP_013876949.1|2547752_2549399_+|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MSKRQLVIFTVGPVQSFIASARKTEDFWSGSYILSYLVREAMKALYQAAPHCEIVYPLVTKEELENPSSRHLHIASIPNRFTAIVNGEAEKVEAILQETDQSVRNVFCDFCFQAIDNVFPFLLDHEKEKLKTTTEAQIRSFLEIYWVAEPYDETESFRQIRERAERRLGALKNEKRYGSVPQHGLVCTVCKEREALCLEDIDEFDRYGAMKQKLVRTWERRAGIYKEPEENSEQEQYVGRIKKNEFLCGICLGKRVARDYFTPIFETAGTKFRIFPSVTEIGSGKYYAIVMMDGDNMGKWFSGENKEDYSRISRKLAHFSQEVVPNIVEKDYHGRLVYAGGDDVLAFVPVDEALKIAEELRFAFSDEKKGLGKGATASVGLIVAHKKAPLQLVLNEVRRLEQKAKSYYSETTKHQKDALAIAVHTRSGEISEAVLPWTVEQEKITDELHQFLLLLKESLSPTFIHHFTQAFYPLLHEDYHSKWENKEMVRTELRRLLKRSVKEGAKINNLDSHVETLMKLYDIVPSGYDFLYLLKILTFFKRKEGTEK

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Crispr_ID: NZ_CP012712_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012712_8

2541638-2543934

TypeIII

Consensus_repeat	Method
GTTTTTATCTTACCTATAAGGAATTGAAAC	PILER-CR
GTTTTTATCTTACCTATAAGGAATTGAAAC	CRISPRCasFinder
GTTTTTATCTTACCTATAAGGAATTGAAAC	CRT

34 spacers

csm6,csx1,cmr1gr7,cas10,cmr3gr5,cmr4gr7,cmr5gr11

The CRISPR arrays of NZ_CP012712_8

>merge|NZ_CP012712|8|2541638-2543934|PILER-CR,CRISPRCasFinder,CRT
GTTTTTATCTTACCTATAAGGAATTGAAACTCAAAGGATACAAATTGAGATGCTTGTTGCAGTACCGGTTTTTATCTTACCTATAAGGAATTGAAACCACTCACAATGAGCACCCTAAAAATTCAAGTATTCGTGGTTTTTATCTTACCTATAAGGAATTGAAACTATATAGATCAAACAACAACTCTCTTGGGAGTTCGTTTGTTTTTATCTTACCTATAAGGAATTGAAACTGGCATTTGTGAAGCAGCGATACCTTTTGCCATCCAGGTTTTTATCTTACCTATAAGGAATTGAAACGGCGTTCACCCCTTCGATTTTGATTCCGAGGAGGTCAGTTTTTATCTTACCTATAAGGAATTGAAACAAGGCGTAAGAAAAGAACACTGATCATTAAAATTATTGTTTTTATCTTACCTATAAGGAATTGAAACTGATTCTTATACCACTTTGAAAAAGCGACAGAATCGTTTTTATCTTACCTATAAGGAATTGAAACACACCAGGCATCTTGAAGACCGTGACACTCTTCGTCCCGTTTTTATCTTACCTATAAGGAATTGAAACATGACGCAAACCAACGCCACTAATTGCGTCCTCGCGTTTTTATCTTACCTATAAGGAATTGAAACTTTTCGTTTTGTTTCCGCAGCGAATGAACGTTTATGTTTTTATCTTACCTATAAGGAATTGAAACAACGCCGTGTCGTTGCTAGCAACCGACGGCAAAACCGTTTTTATCTTACCTATAAGGAATTGAAACCAGTTTTGGTTGATATCATCGATGGGGTCGAAAGTGTGTTTTTATCTTACCTATAAGGAATTGAAACTCGGTTATGCCGCTGGATTCATGGTATTGAAATCCAGTTTTTATCTTACCTATAAGGAATTGAAACTAAAATTACACATGACTTGGCGAAGAAAATCGCGCAGGTGTTTTTATCTTACCTATAAGGAATTGAAACTCAAACGGTCGATGATACCGAGCCGGAACCCTAACATGTTTTTATCTTACCTATAAGGAATTGAAACGGCGAATAAAATCTGACGAAAATTCGTTCGAGGGGGTTTTTATCTTACCTATAAGGAATTGAAACTAATAAATATAATTCGTAGTCACACTAGTAACCTCAAAGTTTTTATCTTACCTATAAGGAATTGAAACCACTACTGCATGCACGAACTCCGCTATTCACCATCACAGTTTTTATCTTACCTATAAGGAATTGAAACCCAAAATCACTGGACAGTATTGGGTAGGCATACCGAGGTTTTTATCTTACCTATAAGGAATTGAAACCAAGTCATGTGATATGACGTAAATGAACCGTCTGTTGTTTTTATCTTACCTATAAGGAATTGAAACGGGAAGTTGCCACTAAAGATGTATCAAAAGACGGAACGTTTTTATCTTACCTATAAGGAATTGAAACATTTCGGTCGAACGAGTGCATCCTCCAAGAATCACACGTTTTTATCTTACCTATAAGGAATTGAAACTGTTTATTTAAGAAAGATGAAAGGATTGGCATGTATCCGTTTTTATCTTACCTATAAGGAATTGAAACTTTTATAAACAAGCTTTTGGTACGGATTTAGTTGGCGAGTTTTTATCTTACCTATAAGGAATTGAAACAAGCCACGCTGGGCAAACGATGTGCCAAGCCGCAGAGGTTTTTATCTTACCTATAAGGAATTGAAACATACAATGTTAAAAGATTTATATGCATTAGGCATGACGTTTTTATCTTACCTATAAGGAATTGAAACTCTATTCTTCCGTGATAAAACAAGTAAACTATCTGAGTTTTTATCTTACCTATAAGGAATTGAAACTTTTGATAGTCTGTTTTCACTTTTTCTAATTCCTCGTTTTTATCTTACCTATAAGGAATTGAAACAAACGCAGATGGAGGCTTTATCGAAAGGCGTCAACGTTTTTATCTTACCTATAAGGAATTGAAACCAAGAAAATTTGAAGATTGGAAAAAAGGATACTTGCGTTTTTATCTTACCTATAAGGAATTGAAACAGTCGTTCATGGTGTCATACGGAATGACAATATCATGGTTTTTATCTTACCTATAAGGAATTGAAACAGATCAACCCTCGCGATAGTGATGCGGTCAATCTGGTTTTTATCTTACCTATAAGGAATTGAAACACGGAATGGAGGACGCAAAATCATGACGCAAACAACGTTTTTATCTTACCTATAAGGAATTGAAACATGGCGGCAACGCACATTTGCAAGTAACAGAACTGTCGTTTTTATCTTACCTATGAAGAATTGAAAC

>NZ_CP012712|8|5|2541638-2543934|PILER-CR
GTTTTTATCTTACCTATAAGGAATTGAAAC	TCAAAGGATACAAATTGAGATGCTTGTTGCAGTACCG
GTTTTTATCTTACCTATAAGGAATTGAAAC	CACTCACAATGAGCACCCTAAAAATTCAAGTATTCGTG
GTTTTTATCTTACCTATAAGGAATTGAAAC	TATATAGATCAAACAACAACTCTCTTGGGAGTTCGTTT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TGGCATTTGTGAAGCAGCGATACCTTTTGCCATCCAG
GTTTTTATCTTACCTATAAGGAATTGAAAC	GGCGTTCACCCCTTCGATTTTGATTCCGAGGAGGTCA
GTTTTTATCTTACCTATAAGGAATTGAAAC	AAGGCGTAAGAAAAGAACACTGATCATTAAAATTATT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TGATTCTTATACCACTTTGAAAAAGCGACAGAATC
GTTTTTATCTTACCTATAAGGAATTGAAAC	ACACCAGGCATCTTGAAGACCGTGACACTCTTCGTCCC
GTTTTTATCTTACCTATAAGGAATTGAAAC	ATGACGCAAACCAACGCCACTAATTGCGTCCTCGC
GTTTTTATCTTACCTATAAGGAATTGAAAC	TTTTCGTTTTGTTTCCGCAGCGAATGAACGTTTAT
GTTTTTATCTTACCTATAAGGAATTGAAAC	AACGCCGTGTCGTTGCTAGCAACCGACGGCAAAACC
GTTTTTATCTTACCTATAAGGAATTGAAAC	CAGTTTTGGTTGATATCATCGATGGGGTCGAAAGTGT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TCGGTTATGCCGCTGGATTCATGGTATTGAAATCCA
GTTTTTATCTTACCTATAAGGAATTGAAAC	TAAAATTACACATGACTTGGCGAAGAAAATCGCGCAGGT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TCAAACGGTCGATGATACCGAGCCGGAACCCTAACAT
GTTTTTATCTTACCTATAAGGAATTGAAAC	GGCGAATAAAATCTGACGAAAATTCGTTCGAGGGG
GTTTTTATCTTACCTATAAGGAATTGAAAC	TAATAAATATAATTCGTAGTCACACTAGTAACCTCAAA
GTTTTTATCTTACCTATAAGGAATTGAAAC	CACTACTGCATGCACGAACTCCGCTATTCACCATCACA
GTTTTTATCTTACCTATAAGGAATTGAAAC	CCAAAATCACTGGACAGTATTGGGTAGGCATACCGAG
GTTTTTATCTTACCTATAAGGAATTGAAAC	CAAGTCATGTGATATGACGTAAATGAACCGTCTGTT
GTTTTTATCTTACCTATAAGGAATTGAAAC	GGGAAGTTGCCACTAAAGATGTATCAAAAGACGGAAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	ATTTCGGTCGAACGAGTGCATCCTCCAAGAATCACAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	TGTTTATTTAAGAAAGATGAAAGGATTGGCATGTATCC
GTTTTTATCTTACCTATAAGGAATTGAAAC	TTTTATAAACAAGCTTTTGGTACGGATTTAGTTGGCGA
GTTTTTATCTTACCTATAAGGAATTGAAAC	AAGCCACGCTGGGCAAACGATGTGCCAAGCCGCAGAG
GTTTTTATCTTACCTATAAGGAATTGAAAC	ATACAATGTTAAAAGATTTATATGCATTAGGCATGAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	TCTATTCTTCCGTGATAAAACAAGTAAACTATCTGA
GTTTTTATCTTACCTATAAGGAATTGAAAC	TTTTGATAGTCTGTTTTCACTTTTTCTAATTCCTC
GTTTTTATCTTACCTATAAGGAATTGAAAC	AAACGCAGATGGAGGCTTTATCGAAAGGCGTCAAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	CAAGAAAATTTGAAGATTGGAAAAAAGGATACTTGC
GTTTTTATCTTACCTATAAGGAATTGAAAC	AGTCGTTCATGGTGTCATACGGAATGACAATATCATG
GTTTTTATCTTACCTATAAGGAATTGAAAC	AGATCAACCCTCGCGATAGTGATGCGGTCAATCTG
GTTTTTATCTTACCTATAAGGAATTGAAAC	ACGGAATGGAGGACGCAAAATCATGACGCAAACAAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	ATGGCGGCAACGCACATTTGCAAGTAACAGAACTGTC
GTTTTTATCTTACCTATGAAGAATTGAAAC

>NZ_CP012712|8|8|2541638-2543934|CRISPRCasFinder
GTTTTTATCTTACCTATAAGGAATTGAAAC	TCAAAGGATACAAATTGAGATGCTTGTTGCAGTACCG
GTTTTTATCTTACCTATAAGGAATTGAAAC	CACTCACAATGAGCACCCTAAAAATTCAAGTATTCGTG
GTTTTTATCTTACCTATAAGGAATTGAAAC	TATATAGATCAAACAACAACTCTCTTGGGAGTTCGTTT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TGGCATTTGTGAAGCAGCGATACCTTTTGCCATCCAG
GTTTTTATCTTACCTATAAGGAATTGAAAC	GGCGTTCACCCCTTCGATTTTGATTCCGAGGAGGTCA
GTTTTTATCTTACCTATAAGGAATTGAAAC	AAGGCGTAAGAAAAGAACACTGATCATTAAAATTATT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TGATTCTTATACCACTTTGAAAAAGCGACAGAATC
GTTTTTATCTTACCTATAAGGAATTGAAAC	ACACCAGGCATCTTGAAGACCGTGACACTCTTCGTCCC
GTTTTTATCTTACCTATAAGGAATTGAAAC	ATGACGCAAACCAACGCCACTAATTGCGTCCTCGC
GTTTTTATCTTACCTATAAGGAATTGAAAC	TTTTCGTTTTGTTTCCGCAGCGAATGAACGTTTAT
GTTTTTATCTTACCTATAAGGAATTGAAAC	AACGCCGTGTCGTTGCTAGCAACCGACGGCAAAACC
GTTTTTATCTTACCTATAAGGAATTGAAAC	CAGTTTTGGTTGATATCATCGATGGGGTCGAAAGTGT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TCGGTTATGCCGCTGGATTCATGGTATTGAAATCCA
GTTTTTATCTTACCTATAAGGAATTGAAAC	TAAAATTACACATGACTTGGCGAAGAAAATCGCGCAGGT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TCAAACGGTCGATGATACCGAGCCGGAACCCTAACAT
GTTTTTATCTTACCTATAAGGAATTGAAAC	GGCGAATAAAATCTGACGAAAATTCGTTCGAGGGG
GTTTTTATCTTACCTATAAGGAATTGAAAC	TAATAAATATAATTCGTAGTCACACTAGTAACCTCAAA
GTTTTTATCTTACCTATAAGGAATTGAAAC	CACTACTGCATGCACGAACTCCGCTATTCACCATCACA
GTTTTTATCTTACCTATAAGGAATTGAAAC	CCAAAATCACTGGACAGTATTGGGTAGGCATACCGAG
GTTTTTATCTTACCTATAAGGAATTGAAAC	CAAGTCATGTGATATGACGTAAATGAACCGTCTGTT
GTTTTTATCTTACCTATAAGGAATTGAAAC	GGGAAGTTGCCACTAAAGATGTATCAAAAGACGGAAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	ATTTCGGTCGAACGAGTGCATCCTCCAAGAATCACAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	TGTTTATTTAAGAAAGATGAAAGGATTGGCATGTATCC
GTTTTTATCTTACCTATAAGGAATTGAAAC	TTTTATAAACAAGCTTTTGGTACGGATTTAGTTGGCGA
GTTTTTATCTTACCTATAAGGAATTGAAAC	AAGCCACGCTGGGCAAACGATGTGCCAAGCCGCAGAG
GTTTTTATCTTACCTATAAGGAATTGAAAC	ATACAATGTTAAAAGATTTATATGCATTAGGCATGAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	TCTATTCTTCCGTGATAAAACAAGTAAACTATCTGA
GTTTTTATCTTACCTATAAGGAATTGAAAC	TTTTGATAGTCTGTTTTCACTTTTTCTAATTCCTC
GTTTTTATCTTACCTATAAGGAATTGAAAC	AAACGCAGATGGAGGCTTTATCGAAAGGCGTCAAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	CAAGAAAATTTGAAGATTGGAAAAAAGGATACTTGC
GTTTTTATCTTACCTATAAGGAATTGAAAC	AGTCGTTCATGGTGTCATACGGAATGACAATATCATG
GTTTTTATCTTACCTATAAGGAATTGAAAC	AGATCAACCCTCGCGATAGTGATGCGGTCAATCTG
GTTTTTATCTTACCTATAAGGAATTGAAAC	ACGGAATGGAGGACGCAAAATCATGACGCAAACAAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	ATGGCGGCAACGCACATTTGCAAGTAACAGAACTGTC
GTTTTTATCTTACCTATGAAGAATTGAAAC

>NZ_CP012712|8|5|2541638-2543934|CRT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TCAAAGGATACAAATTGAGATGCTTGTTGCAGTACCG
GTTTTTATCTTACCTATAAGGAATTGAAAC	CACTCACAATGAGCACCCTAAAAATTCAAGTATTCGTG
GTTTTTATCTTACCTATAAGGAATTGAAAC	TATATAGATCAAACAACAACTCTCTTGGGAGTTCGTTT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TGGCATTTGTGAAGCAGCGATACCTTTTGCCATCCAG
GTTTTTATCTTACCTATAAGGAATTGAAAC	GGCGTTCACCCCTTCGATTTTGATTCCGAGGAGGTCA
GTTTTTATCTTACCTATAAGGAATTGAAAC	AAGGCGTAAGAAAAGAACACTGATCATTAAAATTATT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TGATTCTTATACCACTTTGAAAAAGCGACAGAATC
GTTTTTATCTTACCTATAAGGAATTGAAAC	ACACCAGGCATCTTGAAGACCGTGACACTCTTCGTCCC
GTTTTTATCTTACCTATAAGGAATTGAAAC	ATGACGCAAACCAACGCCACTAATTGCGTCCTCGC
GTTTTTATCTTACCTATAAGGAATTGAAAC	TTTTCGTTTTGTTTCCGCAGCGAATGAACGTTTAT
GTTTTTATCTTACCTATAAGGAATTGAAAC	AACGCCGTGTCGTTGCTAGCAACCGACGGCAAAACC
GTTTTTATCTTACCTATAAGGAATTGAAAC	CAGTTTTGGTTGATATCATCGATGGGGTCGAAAGTGT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TCGGTTATGCCGCTGGATTCATGGTATTGAAATCCA
GTTTTTATCTTACCTATAAGGAATTGAAAC	TAAAATTACACATGACTTGGCGAAGAAAATCGCGCAGGT
GTTTTTATCTTACCTATAAGGAATTGAAAC	TCAAACGGTCGATGATACCGAGCCGGAACCCTAACAT
GTTTTTATCTTACCTATAAGGAATTGAAAC	GGCGAATAAAATCTGACGAAAATTCGTTCGAGGGG
GTTTTTATCTTACCTATAAGGAATTGAAAC	TAATAAATATAATTCGTAGTCACACTAGTAACCTCAAA
GTTTTTATCTTACCTATAAGGAATTGAAAC	CACTACTGCATGCACGAACTCCGCTATTCACCATCACA
GTTTTTATCTTACCTATAAGGAATTGAAAC	CCAAAATCACTGGACAGTATTGGGTAGGCATACCGAG
GTTTTTATCTTACCTATAAGGAATTGAAAC	CAAGTCATGTGATATGACGTAAATGAACCGTCTGTT
GTTTTTATCTTACCTATAAGGAATTGAAAC	GGGAAGTTGCCACTAAAGATGTATCAAAAGACGGAAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	ATTTCGGTCGAACGAGTGCATCCTCCAAGAATCACAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	TGTTTATTTAAGAAAGATGAAAGGATTGGCATGTATCC
GTTTTTATCTTACCTATAAGGAATTGAAAC	TTTTATAAACAAGCTTTTGGTACGGATTTAGTTGGCGA
GTTTTTATCTTACCTATAAGGAATTGAAAC	AAGCCACGCTGGGCAAACGATGTGCCAAGCCGCAGAG
GTTTTTATCTTACCTATAAGGAATTGAAAC	ATACAATGTTAAAAGATTTATATGCATTAGGCATGAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	TCTATTCTTCCGTGATAAAACAAGTAAACTATCTGA
GTTTTTATCTTACCTATAAGGAATTGAAAC	TTTTGATAGTCTGTTTTCACTTTTTCTAATTCCTC
GTTTTTATCTTACCTATAAGGAATTGAAAC	AAACGCAGATGGAGGCTTTATCGAAAGGCGTCAAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	CAAGAAAATTTGAAGATTGGAAAAAAGGATACTTGC
GTTTTTATCTTACCTATAAGGAATTGAAAC	AGTCGTTCATGGTGTCATACGGAATGACAATATCATG
GTTTTTATCTTACCTATAAGGAATTGAAAC	AGATCAACCCTCGCGATAGTGATGCGGTCAATCTG
GTTTTTATCTTACCTATAAGGAATTGAAAC	ACGGAATGGAGGACGCAAAATCATGACGCAAACAAC
GTTTTTATCTTACCTATAAGGAATTGAAAC	ATGGCGGCAACGCACATTTGCAAGTAACAGAACTGTC
GTTTTTATCTTACCTATGAAGAATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012712.1\|WP_042385329.1\|2550522_2551410_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl\|CDD\|274210
NZ_CP012712.1\|WP_155267350.1\|2532765_2533002_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224513
NZ_CP012712.1\|WP_003250597.1\|2538532_2539516_+\|NAD-dependent-epimerase	unknown	unknown	gnl\|CDD\|187563
NZ_CP012712.1\|WP_042385319.1\|2537061_2538393_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NZ_CP012712.1\|WP_042385336.1\|2554293_2556174_+\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|224250
NZ_CP012712.1\|WP_042385323.1\|2544306_2545506_+\|CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
NZ_CP012712.1\|WP_013876957.1\|2524903_2525869_-\|anti-sigma-factor-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|372728
NZ_CP012712.1\|WP_013876950.1\|2546850_2547756_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	cd09657_cmr1gr7_CAS-III-C	gnl\|CDD\|187788
NZ_CP012712.1\|WP_013876949.1\|2547752_2549399_+\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
NZ_CP012712.1\|WP_003250592.1\|2556245_2556665_+\|CoA-binding-protein	unknown	unknown	gnl\|CDD\|224745
NZ_CP012712.1\|WP_003250613.1\|2525852_2526365_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274361
NZ_CP012712.1\|WP_013400931.1\|2528363_2529599_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NZ_CP012712.1\|WP_042385318.1\|2535071_2536529_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP012712.1\|WP_035502040.1\|2554042_2554225_+\|DUF255-domain-containing-protein	unknown	unknown	gnl\|CDD\|367384
NZ_CP012712.1\|WP_042385326.1\|2545511_2546825_+\|TIGR02221-family-CRISPR-associated-protein	csx1	cd09732_csx1_CAS-III	gnl\|CDD\|378186
NZ_CP012712.1\|WP_003250604.1\|2533975_2535070_+\|CotS-family-spore-coat-protein	unknown	unknown	gnl\|CDD\|131952
NZ_CP012712.1\|WP_013400886.1\|2524081_2524726_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_155267349.1\|2532417_2532702_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224513
NZ_CP012712.1\|WP_013876948.1\|2549395_2550523_+\|type-III-B-CRISPR-module-associated-protein-Cmr3	cmr3gr5	pfam09700_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
NZ_CP012712.1\|WP_042385332.1\|2551424_2551832_+\|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	gnl\|CDD\|378242

Protein	Function_ID	Function_description	E-value
NZ_CP012712.1\|WP_042385329.1\|2550522_2551410_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	2.40797e-74
NZ_CP012712.1\|WP_155267350.1\|2532765_2533002_+\|hypothetical-protein	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	2.69556e-10
NZ_CP012712.1\|WP_003250597.1\|2538532_2539516_+\|NAD-dependent-epimerase	gnl\|CDD\|187563	cd05253, UDP_GE_SDE_e, UDP glucuronic acid epimerase, extended (e) SDRs. This subgroup contains UDP-D-glucuronic acid 4-epimerase, an extended SDR, which catalyzes the conversion of UDP-alpha-D-glucuronic acid to UDP-alpha-D-galacturonic acid. This group has the SDR's canonical catalytic tetrad and the TGxxGxxG NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NZ_CP012712.1\|WP_042385319.1\|2537061_2538393_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NZ_CP012712.1\|WP_042385336.1\|2554293_2556174_+\|thioredoxin-domain-containing-protein	gnl\|CDD\|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP012712.1\|WP_042385323.1\|2544306_2545506_+\|CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	3.03838e-10
NZ_CP012712.1\|WP_013876957.1\|2524903_2525869_-\|anti-sigma-factor-C-terminal-domain-containing-protein	gnl\|CDD\|372728	pfam13791, Sigma_reg_C, Sigma factor regulator C-terminal. This family is the C-terminal domain of a sigma factor regulator, this may represent a sensory domain.	1.76867e-20
NZ_CP012712.1\|WP_013876950.1\|2546850_2547756_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	gnl\|CDD\|187788	cd09657, Cmr1_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	8.14003e-12
NZ_CP012712.1\|WP_013876949.1\|2547752_2549399_+\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	3.13284e-93
NZ_CP012712.1\|WP_003250613.1\|2525852_2526365_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|274361	TIGR02950, RNA_polymerase_ECF-type_sigma_factor, RNA polymerase sigma factor, SigM family. This family of RNA polymerase sigma factors is a member of the Sigma-70 subfamily (TIGR02937) and is restricted to certain lineages of the order Bacillales. This family encompasses at least two distinct sigma factors as two proteins are found in each of B. anthracis, B. subtilis subsp. subtilis str. 168, and B. lichiniformis (although these are not apparently the same two in each). One of these is designated as SigM in B. subtilis (Swiss_Prot: SIGM_BACSU) and is activated by various stressors.	4.33334e-21
NZ_CP012712.1\|WP_013400931.1\|2528363_2529599_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	1.74074e-156
NZ_CP012712.1\|WP_042385318.1\|2535071_2536529_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	4.03275e-71
NZ_CP012712.1\|WP_035502040.1\|2554042_2554225_+\|DUF255-domain-containing-protein	gnl\|CDD\|367384	pfam03190, Thioredox_DsbH, Protein of unknown function, DUF255.	8.26522e-23
NZ_CP012712.1\|WP_013876948.1\|2549395_2550523_+\|type-III-B-CRISPR-module-associated-protein-Cmr3	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	2.87238e-53
NZ_CP012712.1\|WP_003250604.1\|2533975_2535070_+\|CotS-family-spore-coat-protein	gnl\|CDD\|131952	TIGR02906, Spore_coat_protein_S, spore coat protein, CotS family. Members of this family include the spore coat proteins CotS and YtaA from Bacillus subtilis and, from other endospore-forming bacteria, homologs that are more closely related to these two than to the spore coat proteins YutH and YsxE. The CotS family is more broadly distributed than YutH or YsxE, but still is not universal among spore-formers. [Cellular processes, Sporulation and germination].	3.10075e-110
NZ_CP012712.1\|WP_042385326.1\|2545511_2546825_+\|TIGR02221-family-CRISPR-associated-protein	gnl\|CDD\|378186	pfam09455, Cas_DxTHG, CRISPR-associated (Cas) DxTHG family. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.	1.25868e-70
NZ_CP012712.1\|WP_155267349.1\|2532417_2532702_+\|hypothetical-protein	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	1.13126e-11
NZ_CP012712.1\|WP_003250592.1\|2556245_2556665_+\|CoA-binding-protein	gnl\|CDD\|224745	COG1832, COG1832, Predicted CoA-binding protein [General function prediction only].	1.09542e-64
NZ_CP012712.1\|WP_042385332.1\|2551424_2551832_+\|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	1.19338e-35

>NZ_CP012712.1|WP_003250597.1|2538532_2539516_+|NAD-dependent-epimerase
MQNNAKYIFITGCAGFIGFHLTKRLLDEGFSVLGMDDMNDYYDTSLKYDRLKIVMKHPHFRFVKGSIENIELLEKLFSQYDVDTVVNLAAQPGVRYSLKNPHKYIQANVVGFANILECCKKHKIRHLIYASSSSVYGNNKNAPFSVADRTDSPVSLYAATKKANELMAYTYSHLYRLPTTGLRFFTVYGPWGRPDMALFKFANAIVKQQPIEIYNYGNMKRDFTYVDDVTESILRLIDKGPSTESPYKIYNIGNNQPVQLNYFIEVLEEHLGKKAIKKLLPMQPGDVPETFADIDELVKDINYKPKVSIEEGIKRFVEWFKDYYKIN
>NZ_CP012712.1|WP_042385319.1|2537061_2538393_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MNIAMIGAGYVGTATSVAFAEYGHKVYVIERDWEKLKKLKMSVLPFFEEGMEELFKKHSANGNLLFFHYIEEVIDQCEILMITVGTPSLPNGEADLSYVEEAARQIGRSMNEYKAIVIKSTVPVGTGDKINKIIKTELKKRNKEISFDLISNPEFLREGKALQDALHPERIVIGCETEKARQVMKELYSGINSPILFTTVKDAEMIKYASNAFLATKISFINELARLCDKVGANVIQVAKGMGLDSRIGPQFLQAGIGFGGSCFPKDVKALLALASAEKTPLQILQAVLDVNETQAQWFMEKVKKALGSLSRKRIAVLGLTFKPQTDDIREASSLKIIHYLLQNNACITAYDPQGTEHVKKIYPTINYAKTTLEALNGADAALIVTEWKEIIEIDWKKAKSILSQPFVFDGRNCLDASVMLELGYHYEGVGTPNLDERINGSF
>NZ_CP012712.1|WP_042385318.1|2535071_2536529_+|glycosyltransferase-family-4-protein
MKILMICTEKLPVPPVRGGAIQTYISGVLPYLSKHHDITVLGISDPSLPDQETLDGVHYVRVPGKIFEIYREGVVRYIESNSFDLIHIFNRPRLVLPVRQAAPHAKITLSMHNDMFNIEKIDPEEATAVLEEVSSIVTVSNYVGNVIRQLYPQASPKIRTIYSGVDTERFLPGSHPKMQETRKEIRKAHGLENKTVILFAGRLSRNKGVDKLVRALPELSKKFKDLALVIVGSNWFSQNNVTDYVAYVRALAKKVPVPVVTTGFVAPDEIQNWFAAADLFVCTSQWQEPLARVHYEAMAAGLPIVTTARGGNPEVIFSEENGLVVENPEDPSNFAEKIAKILFDKSLMKKMGERGRELAVSRYKWERVASELLEVWNQAVHMTSTTAVEQDSTDKTNQTGAKELEYVIEHNSETKKEDEKAAMEQDSAEKISEDEVNNTEVEEPESVARIKIIDVDEETIRNSIWFSSTYKRGRKRNNRRGRKGS
>NZ_CP012712.1|WP_003250604.1|2533975_2535070_+|CotS-family-spore-coat-protein
MESIFIEPWEVDESTHEFFIPDYINELADKVLKHYDFSVESIQVVTTKPDKGGAIWKLETSAGPKSLKLLHRRPTRSLFSLGAQEYLVDVRHARVPPIVKTKDGTNYVEAGGKLWFVAEWIESLTPVTKDLEGAKLLCSALGEFHRLSKGYVPPPQAETASRLHKWRRNYEKIIYKMDWFRNIAKAYNELPASSYLLNVIDEFEEQARRSLERLDQSSYFELIKHGNAYWGLVHQDYGWSNGQMGRDGMWIIDLDGVAFDLPIRDLRKLISGTMADLYKWDAKWIREMIKAYHKENPISPELYEILMIDLSLPNEFYKNIKEVVYDPEMFLNEQTVQLMKTIIDTDQTKWPVLAEIQNDWKEVE
>NZ_CP012712.1|WP_155267350.1|2532765_2533002_+|hypothetical-protein
MMDFSTFASVHSITKRDLLRTFPKAYKGKHIFHPGVAMIKGKQVEVTSELPVIVQSDGEVLAKTPVNVTIRKDALLIV
>NZ_CP012712.1|WP_155267349.1|2532417_2532702_+|hypothetical-protein
MDYKKALERILMGKQRKIDVGRIDEEYCITVVGIGLDGKVAEVNNISKYKKWFNFIRLGALSYVLSFLQVLLKYRPVNIQLNVDGEKLVFLMSG
>NZ_CP012712.1|WP_013400931.1|2528363_2529599_+|IS256-family-transposase
MAQYHITLNDELLHGLFTRDEGLAKLLEQVLNQILEAQVEEQLGARRYERTEERKGYRNGSYPRQLTTRVGRLTLRVPRTRDGEFSTELFQRYQRSEQALVLALMEMVVNGVSTRKITQITEELCGTSFSKSTVSSLCKGLDPIIQDWNYRSLHEHVYPFVLVDAIYTKVREDGRVRSRAVLIATGVNEEGYREILGLQIGNSESESSWSEFFGWLKDRGLRGVDLIISDQHGGLVQAIEKHFQGATWQRCQTHFIRNILDAAPKYMQDALLEEIRGILHAPNKQTARLLLEQVLAKWEEKAPKAMQILEEGFEDATAVLDYPDRYRRRLRTTNGVERLNEEIRRRERVIRIFPNRESVYRLVGAVLIEIDEKWMSGRKYLDMAEYWKWRKTKEQGVRSVNQEAPAIKRVG
>NZ_CP012712.1|WP_003250613.1|2525852_2526365_-|RNA-polymerase-sigma-factor
MNDFELGEKLHEQLERVKVYLLKMGASLQDAEDITQETAYKFLTYIDSVNIENVESWLFRVSVNQYYDLCRKHNRQKNISLKFNYKELFEEFTPEKAVLQKEFEKDIYILLDRLKPKYAQFLILKYSIGLKLTEIAALYDMKVDSVKTIIHRARKQFIEEYRRHQNERRE
>NZ_CP012712.1|WP_013876957.1|2524903_2525869_-|anti-sigma-factor-C-terminal-domain-containing-protein
MNEENEFLPQDPDFRKLVKKAKRNSALRIVVISLIISIIVVIAFYFVGNSIMINKVNEEVRNDAIWHSIHGANIEEQGTSINYSLFSATSKTEFIKKVNGIPVPWVPVEKEYSIFGQSKIIISKGASGTGNVDEKRIPMYFNGERVIEFIHPKVNSSLFDDRSIVSSMDDDKVIELALSFDKGYKVTDVQKIFNKNISWFWVDTYSESDIKNYNNFIKETGKDFTIIGDDAIGFHYINQPESKWGAEYFIRSLKELKQNGSYKDVADKIIQNITHSNKEKLSAENLEIIGVVITGTPSEIEKFNNVPFVRAASLGVTADRY
>NZ_CP012712.1|WP_013400886.1|2524081_2524726_-|hypothetical-protein
MKKIIKIGIGVFGIVAFGIGLLIFVFLQSMKADEDEVKKVKIQAQGYIKNTFKDEIVIYDTLFDNMGNFPTFDYAAKAENKKDNTQFLIYYNEETKQMEDTYIAEKWEKELENNIRPYIEQKLGTLDEFWVEYDERAGITYNVNPNKPSSYKEYDAAPTILISVPRKPDKKDEEILNEIVAFLQKDVGLKHGTVSMSYIKNGAPLDDKEWFKTF
>NZ_CP012712.1|WP_042385323.1|2544306_2545506_+|CRISPR-associated-protein
MYQHIVITCGISLLTGKANVFSINRDETMAEIRSLLDVKEINKEIEKKVERWLQYAKQFSHEVVHRPNHVSAEYSTVHELRKKGKLVERPTIVLFVTQTVGGRIVESILTSLLEMHFQANVRVIYVDIDVKNPKRMHETLGEYMSKLSYALSKGEPTSTCSAPIGGYKVMTSLGYIVGAFLNYPTAYLHEDHQVLHEIPPVPIHIKEEFVYEHLDLLRKCQKDVVPVQELSYQEKRCVEQYPSLFYQEDGFVCLSAFGEFLLEHEKYRHLFDTAYFVSKQILDVMEHNRHQSLFIFQQFHELVKKLKYKEGNMFELQHEKEFKTIRQKQIKYHLYKGASNGQTAFRLAYRYDEQKDRLYANYLWLDHKRYEREASQGRGLYEDWSEFFDITNDLMTVVK
>NZ_CP012712.1|WP_042385326.1|2545511_2546825_+|TIGR02221-family-CRISPR-associated-protein
MARNVLLSFLGRNDYEYCFYTYRGQRSSYTRFVQTAIYELFRNEEPMDVIIFATKEAKESNWNDKVREGQQVKGIQTAFQQIAPEATVKLVEIESGQDESANWKLFDSIIAEIGEGDTIYFDITHSFRSIPFVALIVLNYARLVKKATIGALAYGWFEKLGRPNEVKQLSPEQRLVPIVDLTNMAQLLDWTNGVDQFLRTGDASLIKELTARENRKVFCDANASPLLKREVEKLNKLAKQLDRTGNSIRTCRSLQVEEEVEKFRYQLEQVRHSQAEAIKPLVPILDEMEKKYSNFGGNTIINGWEVARWCVDNGLIQSALTMLSENVVTAICRAFQLEVTNVEIRNDLHSAIRIIIRRTKKEEWEVHSVPFVEEMVEKLLPYRELLKPFGEVAELRNDMNHAGVRERPLTADRFAQRVKTLLDAIKPFFEEMAALSQ
>NZ_CP012712.1|WP_013876950.1|2546850_2547756_+|type-III-B-CRISPR-module-RAMP-protein-Cmr1
MVDNERMKASAIVETTYKLKLITPMAMHGANAGEKAEFRISSLRGVWRYWWRTLQEEKNHTALLEQEEEWFGGTQIKKQKSPVNLLLQRSLSGLKRESILPHRTKKSFAVRTIPAGQETAVVMRTLQKHKQLLETYELYFQYMLHLAGMGQRARRGFGAVQWEGHHWETVADFVASLQEVLIRLGQSERFQFSDSGCIVKRKGEARTYHPVLSAVWVGEGQKTPQEVLKRFGVASHEANRYGRLGAVRPKRFASPLWCTVRKIGDLYYPVVTEVKADSSVYKQPQYQRDRDLFLEIAGVRV
>NZ_CP012712.1|WP_013876949.1|2547752_2549399_+|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MSKRQLVIFTVGPVQSFIASARKTEDFWSGSYILSYLVREAMKALYQAAPHCEIVYPLVTKEELENPSSRHLHIASIPNRFTAIVNGEAEKVEAILQETDQSVRNVFCDFCFQAIDNVFPFLLDHEKEKLKTTTEAQIRSFLEIYWVAEPYDETESFRQIRERAERRLGALKNEKRYGSVPQHGLVCTVCKEREALCLEDIDEFDRYGAMKQKLVRTWERRAGIYKEPEENSEQEQYVGRIKKNEFLCGICLGKRVARDYFTPIFETAGTKFRIFPSVTEIGSGKYYAIVMMDGDNMGKWFSGENKEDYSRISRKLAHFSQEVVPNIVEKDYHGRLVYAGGDDVLAFVPVDEALKIAEELRFAFSDEKKGLGKGATASVGLIVAHKKAPLQLVLNEVRRLEQKAKSYYSETTKHQKDALAIAVHTRSGEISEAVLPWTVEQEKITDELHQFLLLLKESLSPTFIHHFTQAFYPLLHEDYHSKWENKEMVRTELRRLLKRSVKEGAKINNLDSHVETLMKLYDIVPSGYDFLYLLKILTFFKRKEGTEK
>NZ_CP012712.1|WP_013876948.1|2549395_2550523_+|type-III-B-CRISPR-module-associated-protein-Cmr3
MTKLTLKPVDTFFFKNHHVTEAGEDTVMESMFPPRPNTIYGALRAAYIHTHTTFDEFVRETDEHVKRWMGTPNQRGEFRLQYCALTYKQDILLPLPLDYQVIEEKKSLKAYPLLLANDEKPSSLQGKWRLASTRREKTKSSQHQYVSLQEWKHAILHEAPISSLISLSKLVVREEKVGIRLDIGSRTAQEGLLYRVMQGRFRDDGALAVYIGNGPDFSKVKFARIGGENRPWIIQQSEETFTLWDEKEKKQLAEKIAQTKVAKIIFLSPAIFESGSRPCNFDGEKVTLPNGVTVKWLTAAIGRPELYGGWDIVRHRPKPRKWMVPAGSVIYVEVEEEDISKLLFVANGMHFTDEGAEEGFGFAVIASASKSEEEL
>NZ_CP012712.1|WP_042385329.1|2550522_2551410_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MYSIVRPFFLHAVTSVHAGSGSEIGLVDLPIQREKHTGFPKIESSSLKGALRYHITQSLREKGEDKKLELIFGSEKGKENETQASAIALSDARVLLFPVKSLRGVFAWITCPQVLERWNNEIALYDISIDPLLVPSPNTVSSDRLIAANQHIVLEEYTFEVTVSDDAKQLADQLAKLLSDHVQINIQDRLVVLSDDDFTDFVKLSTEVNARIKIDHEKGTVDKDNGALWYEENVPPETIFYSFLYIGNVRGKGMEGLQKAEDVKAFLVKENTFPKVFQLGGNSTLGRGILRTIWV
>NZ_CP012712.1|WP_042385332.1|2551424_2551832_+|type-III-B-CRISPR-module-associated-protein-Cmr5
MAKNIQRVGIENGRAAFAFEAVKKVKEDKRIGKFENYRSYVKKMPSLIQVNGLGQALAFCYQKEKEYEAIYQALHEWFQEKYPHAFQGDKKEFVQVVINLPSAEYRLWTMEALALLNWMRKFVDGMAKENEEKEQ
>NZ_CP012712.1|WP_035502040.1|2554042_2554225_+|DUF255-domain-containing-protein
MKEYLERERYNEKYNWLVMSKSPYLKQHETNPVNWLEWSPEAFQKAKREGKPVFLSIGYS
>NZ_CP012712.1|WP_042385336.1|2554293_2556174_+|thioredoxin-domain-containing-protein
MAHESFEDEEVAKILNEKYISIKVDREERPDIDSVYMRVCQMMTGQGGWPLSVFLTPEGKPFYAGTYFPKQSRYGRPGFIELLTRLYDKYKENPDEIVHVAEQVTEALRQSARASGTERLPFAAIEKAYRQLLNGFDAVYGGFGGAPKFPIPHMLMFLMRYYQWKRDDRALLMVEKTLNGMANGGIYDHIGYGFARYSTDAMWLVPHFEKMLYDNALLVIVYTEAYQLTKKERYKEIAEQIIEFVKREMTSQDGAFYSAVDADSEGVEGKYYVWTPDEVVNVLGAELGELYCRVYDITEEGNFAGKNVPNLIHARMERIARRYRLTEEELRERLEEARKQLLAERSSRVRPHVDDKILTAWNALMIAALAKAAKVYERRDYLQMAKQALSFIETRLWQNGRLMVRYRGGEAKHLGIIDDYAYLVWAYVEMYEATLDLAYLQKAKTCVERMISLFWDEKHGAFFMTGNDAEALIIREKEIYDGALPSGNSVAAVQMIRLARLTGDLALLEKAETMYKVFRRQVEAYESGHTFFLQGLLLIETPAAEVVLFGKQGDEKREQFILKWQHAFAPNVFLLVAEHPADVAGIAPFAAEYEPLGDETTVYVCENFACQQPTTDVEFVAEQLFE
>NZ_CP012712.1|WP_003250592.1|2556245_2556665_+|CoA-binding-protein
MPITNPSREEIGEILRKAKRIAVVGLSDNPERTSYTVAKAMKDAGYEIIPVNPMIEEWEGIKAVKKLTDIDGHVDIVNVFRRSEHLPEIAREFVQIDADVFWAQLGVVNEEAYEFLKEKGYTVVMDRCIKVEHALTQQH

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Crispr_ID: NZ_CP012712_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012712_9

2553171-2553530

TypeIII

Consensus_repeat	Method
GTTTTTATCTTACCTATGAGGAATTGAAAC	PILER-CR
GTTTTTATCTTACCTATGAGGAATTGAAAC	CRISPRCasFinder
GTTTTTATCTTACCTATGAGGAATTGAAAC	CRT

5 spacers

cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7,csx1,csm6

The CRISPR arrays of NZ_CP012712_9

>merge|NZ_CP012712|9|2553171-2553530|PILER-CR,CRISPRCasFinder,CRT
GTTTTTATCTTACCTATGAGGAATTGAAACTCATCTTACTAGAGACAAAGAAGCTTTCCACGTCGGAGTTTTTATCTTACCTATGAGGAATTGAAACTATCAACCTCCATTTGATTTTTGAAGGCGATTCCTGTTTTTATCTTACCTATGAGGAATTGAAACATGATTTGGCCATCTGTTTGGAATCCTTTGGCCAAGTTTTTATCTTACCTATGAGGAATTGAAACCTCGGCTGGGAAATCGACGCGAACGGGATGCTTGTTGTTTTTATCTTACCTATGAGGAATTGAAACTTAATTCTCTGATATATGCCTTCTCCTTTTCATCTAAGTTTTTATCTTACCTATAAGGAATTGAAAC

>NZ_CP012712|9|6|2553171-2553530|PILER-CR
GTTTTTATCTTACCTATGAGGAATTGAAAC	TCATCTTACTAGAGACAAAGAAGCTTTCCACGTCGGA
GTTTTTATCTTACCTATGAGGAATTGAAAC	TATCAACCTCCATTTGATTTTTGAAGGCGATTCCT
GTTTTTATCTTACCTATGAGGAATTGAAAC	ATGATTTGGCCATCTGTTTGGAATCCTTTGGCCAA
GTTTTTATCTTACCTATGAGGAATTGAAAC	CTCGGCTGGGAAATCGACGCGAACGGGATGCTTGTT
GTTTTTATCTTACCTATGAGGAATTGAAAC	TTAATTCTCTGATATATGCCTTCTCCTTTTCATCTAA
GTTTTTATCTTACCTATAAGGAATTGAAAC

>NZ_CP012712|9|9|2553171-2553530|CRISPRCasFinder
GTTTTTATCTTACCTATGAGGAATTGAAAC	TCATCTTACTAGAGACAAAGAAGCTTTCCACGTCGGA
GTTTTTATCTTACCTATGAGGAATTGAAAC	TATCAACCTCCATTTGATTTTTGAAGGCGATTCCT
GTTTTTATCTTACCTATGAGGAATTGAAAC	ATGATTTGGCCATCTGTTTGGAATCCTTTGGCCAA
GTTTTTATCTTACCTATGAGGAATTGAAAC	CTCGGCTGGGAAATCGACGCGAACGGGATGCTTGTT
GTTTTTATCTTACCTATGAGGAATTGAAAC	TTAATTCTCTGATATATGCCTTCTCCTTTTCATCTAA
GTTTTTATCTTACCTATAAGGAATTGAAAC

>NZ_CP012712|9|6|2553171-2553530|CRT
GTTTTTATCTTACCTATGAGGAATTGAAAC	TCATCTTACTAGAGACAAAGAAGCTTTCCACGTCGGA
GTTTTTATCTTACCTATGAGGAATTGAAAC	TATCAACCTCCATTTGATTTTTGAAGGCGATTCCT
GTTTTTATCTTACCTATGAGGAATTGAAAC	ATGATTTGGCCATCTGTTTGGAATCCTTTGGCCAA
GTTTTTATCTTACCTATGAGGAATTGAAAC	CTCGGCTGGGAAATCGACGCGAACGGGATGCTTGTT
GTTTTTATCTTACCTATGAGGAATTGAAAC	TTAATTCTCTGATATATGCCTTCTCCTTTTCATCTAA
GTTTTTATCTTACCTATAAGGAATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012712.1\|WP_042385329.1\|2550522_2551410_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl\|CDD\|274210
NZ_CP012712.1\|WP_003250597.1\|2538532_2539516_+\|NAD-dependent-epimerase	unknown	unknown	gnl\|CDD\|187563
NZ_CP012712.1\|WP_042385319.1\|2537061_2538393_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NZ_CP012712.1\|WP_003250588.1\|2561232_2561598_+\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NZ_CP012712.1\|WP_042385323.1\|2544306_2545506_+\|CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
NZ_CP012712.1\|WP_003250585.1\|2562557_2563976_+\|PTS-system-trehalose-specific-EIIBC-component	unknown	unknown	gnl\|CDD\|273916
NZ_CP012712.1\|WP_013876950.1\|2546850_2547756_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	cd09657_cmr1gr7_CAS-III-C	gnl\|CDD\|187788
NZ_CP012712.1\|WP_013876949.1\|2547752_2549399_+\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
NZ_CP012712.1\|WP_013400877.1\|2564089_2565778_+\|alpha,alpha-phosphotrehalase	unknown	unknown	gnl\|CDD\|274115
NZ_CP012712.1\|WP_003250589.1\|2558791_2561236_+\|DNA-topoisomerase-IV-subunit-A	unknown	unknown	gnl\|CDD\|235503
NZ_CP012712.1\|WP_042385336.1\|2554293_2556174_+\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|224250
NZ_CP012712.1\|WP_042385318.1\|2535071_2536529_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP012712.1\|WP_035502040.1\|2554042_2554225_+\|DUF255-domain-containing-protein	unknown	unknown	gnl\|CDD\|367384
NZ_CP012712.1\|WP_003250590.1\|2556821_2558792_+\|DNA-topoisomerase-IV-subunit-B	unknown	unknown	gnl\|CDD\|235542
NZ_CP012712.1\|WP_003250587.1\|2561637_2562309_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133392
NZ_CP012712.1\|WP_035502036.1\|2565801_2566515_+\|trehalose-operon-repressor	unknown	unknown	gnl\|CDD\|274116
NZ_CP012712.1\|WP_013876948.1\|2549395_2550523_+\|type-III-B-CRISPR-module-associated-protein-Cmr3	cmr3gr5	pfam09700_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
NZ_CP012712.1\|WP_042385332.1\|2551424_2551832_+\|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	gnl\|CDD\|378242
NZ_CP012712.1\|WP_042385326.1\|2545511_2546825_+\|TIGR02221-family-CRISPR-associated-protein	csx1	cd09732_csx1_CAS-III	gnl\|CDD\|378186
NZ_CP012712.1\|WP_003250592.1\|2556245_2556665_+\|CoA-binding-protein	unknown	unknown	gnl\|CDD\|224745

Protein	Function_ID	Function_description	E-value
NZ_CP012712.1\|WP_042385329.1\|2550522_2551410_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	2.40797e-74
NZ_CP012712.1\|WP_003250597.1\|2538532_2539516_+\|NAD-dependent-epimerase	gnl\|CDD\|187563	cd05253, UDP_GE_SDE_e, UDP glucuronic acid epimerase, extended (e) SDRs. This subgroup contains UDP-D-glucuronic acid 4-epimerase, an extended SDR, which catalyzes the conversion of UDP-alpha-D-glucuronic acid to UDP-alpha-D-galacturonic acid. This group has the SDR's canonical catalytic tetrad and the TGxxGxxG NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NZ_CP012712.1\|WP_042385319.1\|2537061_2538393_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NZ_CP012712.1\|WP_003250588.1\|2561232_2561598_+\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	3.12053e-08
NZ_CP012712.1\|WP_042385323.1\|2544306_2545506_+\|CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	3.03838e-10
NZ_CP012712.1\|WP_003250585.1\|2562557_2563976_+\|PTS-system-trehalose-specific-EIIBC-component	gnl\|CDD\|273916	TIGR01992, phosphotransferase_system_trehalose_permease, PTS system, trehalose-specific IIBC component. This model represents the fused enzyme II B and C components of the trehalose-specific PTS sugar transporter system. Trehalose is converted to trehalose-6-phosphate in the process of translocation into the cell. These transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci and Streptococci which contain their own A domain as a C-terminal fusion. This family is closely related to the sucrose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively). In E. coli, B. subtilis and P. fluorescens the presence of this gene is associated with the presence of trehalase which degrades T6P to glucose and glucose-6-P. Trehalose may also be transported (in Salmonella) via the mannose PTS or galactose permease systems, or (in Sinorhizobium, Thermococcus and Sulfolobus, for instance) by ABC transporters.	0
NZ_CP012712.1\|WP_013876950.1\|2546850_2547756_+\|type-III-B-CRISPR-module-RAMP-protein-Cmr1	gnl\|CDD\|187788	cd09657, Cmr1_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	8.14003e-12
NZ_CP012712.1\|WP_013876949.1\|2547752_2549399_+\|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	3.13284e-93
NZ_CP012712.1\|WP_013400877.1\|2564089_2565778_+\|alpha,alpha-phosphotrehalase	gnl\|CDD\|274115	TIGR02403, Trehalose-6-phosphate_hydrolase, alpha,alpha-phosphotrehalase. Trehalose is a glucose disaccharide that serves in many biological systems as a compatible solute for protection against hyperosmotic and thermal stress. This family describes trehalose-6-phosphate hydrolase, product of the treC (or treA) gene, which is often found together with a trehalose uptake transporter and a trehalose operon repressor.	0
NZ_CP012712.1\|WP_003250589.1\|2558791_2561236_+\|DNA-topoisomerase-IV-subunit-A	gnl\|CDD\|235503	PRK05561, PRK05561, DNA topoisomerase 4 subunit A.	0
NZ_CP012712.1\|WP_042385336.1\|2554293_2556174_+\|thioredoxin-domain-containing-protein	gnl\|CDD\|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP012712.1\|WP_042385318.1\|2535071_2536529_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	4.03275e-71
NZ_CP012712.1\|WP_035502040.1\|2554042_2554225_+\|DUF255-domain-containing-protein	gnl\|CDD\|367384	pfam03190, Thioredox_DsbH, Protein of unknown function, DUF255.	8.26522e-23
NZ_CP012712.1\|WP_003250590.1\|2556821_2558792_+\|DNA-topoisomerase-IV-subunit-B	gnl\|CDD\|235542	PRK05644, gyrB, DNA gyrase subunit B; Validated.	0
NZ_CP012712.1\|WP_003250587.1\|2561637_2562309_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133392	cd04764, HTH_MlrA-like_sg1, Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators. Putative helix-turn-helix (HTH) MlrA-like transcription regulators (subgroup 1). The MlrA protein, also known as YehV, has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella typhimurium. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules. Many MlrA-like proteins in this group appear to lack the long dimerization helix seen in the N-terminal domains of typical MerR-like proteins.	9.88211e-13
NZ_CP012712.1\|WP_035502036.1\|2565801_2566515_+\|trehalose-operon-repressor	gnl\|CDD\|274116	TIGR02404, Trehalose_operon_transcriptional_repressor, trehalose operon repressor, B. subtilis-type. This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions].	2.55799e-107
NZ_CP012712.1\|WP_013876948.1\|2549395_2550523_+\|type-III-B-CRISPR-module-associated-protein-Cmr3	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	2.87238e-53
NZ_CP012712.1\|WP_042385332.1\|2551424_2551832_+\|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	1.19338e-35
NZ_CP012712.1\|WP_042385326.1\|2545511_2546825_+\|TIGR02221-family-CRISPR-associated-protein	gnl\|CDD\|378186	pfam09455, Cas_DxTHG, CRISPR-associated (Cas) DxTHG family. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.	1.25868e-70
NZ_CP012712.1\|WP_003250592.1\|2556245_2556665_+\|CoA-binding-protein	gnl\|CDD\|224745	COG1832, COG1832, Predicted CoA-binding protein [General function prediction only].	1.09542e-64

>NZ_CP012712.1|WP_042385332.1|2551424_2551832_+|type-III-B-CRISPR-module-associated-protein-Cmr5
MAKNIQRVGIENGRAAFAFEAVKKVKEDKRIGKFENYRSYVKKMPSLIQVNGLGQALAFCYQKEKEYEAIYQALHEWFQEKYPHAFQGDKKEFVQVVINLPSAEYRLWTMEALALLNWMRKFVDGMAKENEEKEQ
>NZ_CP012712.1|WP_042385329.1|2550522_2551410_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MYSIVRPFFLHAVTSVHAGSGSEIGLVDLPIQREKHTGFPKIESSSLKGALRYHITQSLREKGEDKKLELIFGSEKGKENETQASAIALSDARVLLFPVKSLRGVFAWITCPQVLERWNNEIALYDISIDPLLVPSPNTVSSDRLIAANQHIVLEEYTFEVTVSDDAKQLADQLAKLLSDHVQINIQDRLVVLSDDDFTDFVKLSTEVNARIKIDHEKGTVDKDNGALWYEENVPPETIFYSFLYIGNVRGKGMEGLQKAEDVKAFLVKENTFPKVFQLGGNSTLGRGILRTIWV
>NZ_CP012712.1|WP_013876948.1|2549395_2550523_+|type-III-B-CRISPR-module-associated-protein-Cmr3
MTKLTLKPVDTFFFKNHHVTEAGEDTVMESMFPPRPNTIYGALRAAYIHTHTTFDEFVRETDEHVKRWMGTPNQRGEFRLQYCALTYKQDILLPLPLDYQVIEEKKSLKAYPLLLANDEKPSSLQGKWRLASTRREKTKSSQHQYVSLQEWKHAILHEAPISSLISLSKLVVREEKVGIRLDIGSRTAQEGLLYRVMQGRFRDDGALAVYIGNGPDFSKVKFARIGGENRPWIIQQSEETFTLWDEKEKKQLAEKIAQTKVAKIIFLSPAIFESGSRPCNFDGEKVTLPNGVTVKWLTAAIGRPELYGGWDIVRHRPKPRKWMVPAGSVIYVEVEEEDISKLLFVANGMHFTDEGAEEGFGFAVIASASKSEEEL
>NZ_CP012712.1|WP_013876949.1|2547752_2549399_+|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MSKRQLVIFTVGPVQSFIASARKTEDFWSGSYILSYLVREAMKALYQAAPHCEIVYPLVTKEELENPSSRHLHIASIPNRFTAIVNGEAEKVEAILQETDQSVRNVFCDFCFQAIDNVFPFLLDHEKEKLKTTTEAQIRSFLEIYWVAEPYDETESFRQIRERAERRLGALKNEKRYGSVPQHGLVCTVCKEREALCLEDIDEFDRYGAMKQKLVRTWERRAGIYKEPEENSEQEQYVGRIKKNEFLCGICLGKRVARDYFTPIFETAGTKFRIFPSVTEIGSGKYYAIVMMDGDNMGKWFSGENKEDYSRISRKLAHFSQEVVPNIVEKDYHGRLVYAGGDDVLAFVPVDEALKIAEELRFAFSDEKKGLGKGATASVGLIVAHKKAPLQLVLNEVRRLEQKAKSYYSETTKHQKDALAIAVHTRSGEISEAVLPWTVEQEKITDELHQFLLLLKESLSPTFIHHFTQAFYPLLHEDYHSKWENKEMVRTELRRLLKRSVKEGAKINNLDSHVETLMKLYDIVPSGYDFLYLLKILTFFKRKEGTEK
>NZ_CP012712.1|WP_013876950.1|2546850_2547756_+|type-III-B-CRISPR-module-RAMP-protein-Cmr1
MVDNERMKASAIVETTYKLKLITPMAMHGANAGEKAEFRISSLRGVWRYWWRTLQEEKNHTALLEQEEEWFGGTQIKKQKSPVNLLLQRSLSGLKRESILPHRTKKSFAVRTIPAGQETAVVMRTLQKHKQLLETYELYFQYMLHLAGMGQRARRGFGAVQWEGHHWETVADFVASLQEVLIRLGQSERFQFSDSGCIVKRKGEARTYHPVLSAVWVGEGQKTPQEVLKRFGVASHEANRYGRLGAVRPKRFASPLWCTVRKIGDLYYPVVTEVKADSSVYKQPQYQRDRDLFLEIAGVRV
>NZ_CP012712.1|WP_042385326.1|2545511_2546825_+|TIGR02221-family-CRISPR-associated-protein
MARNVLLSFLGRNDYEYCFYTYRGQRSSYTRFVQTAIYELFRNEEPMDVIIFATKEAKESNWNDKVREGQQVKGIQTAFQQIAPEATVKLVEIESGQDESANWKLFDSIIAEIGEGDTIYFDITHSFRSIPFVALIVLNYARLVKKATIGALAYGWFEKLGRPNEVKQLSPEQRLVPIVDLTNMAQLLDWTNGVDQFLRTGDASLIKELTARENRKVFCDANASPLLKREVEKLNKLAKQLDRTGNSIRTCRSLQVEEEVEKFRYQLEQVRHSQAEAIKPLVPILDEMEKKYSNFGGNTIINGWEVARWCVDNGLIQSALTMLSENVVTAICRAFQLEVTNVEIRNDLHSAIRIIIRRTKKEEWEVHSVPFVEEMVEKLLPYRELLKPFGEVAELRNDMNHAGVRERPLTADRFAQRVKTLLDAIKPFFEEMAALSQ
>NZ_CP012712.1|WP_042385323.1|2544306_2545506_+|CRISPR-associated-protein
MYQHIVITCGISLLTGKANVFSINRDETMAEIRSLLDVKEINKEIEKKVERWLQYAKQFSHEVVHRPNHVSAEYSTVHELRKKGKLVERPTIVLFVTQTVGGRIVESILTSLLEMHFQANVRVIYVDIDVKNPKRMHETLGEYMSKLSYALSKGEPTSTCSAPIGGYKVMTSLGYIVGAFLNYPTAYLHEDHQVLHEIPPVPIHIKEEFVYEHLDLLRKCQKDVVPVQELSYQEKRCVEQYPSLFYQEDGFVCLSAFGEFLLEHEKYRHLFDTAYFVSKQILDVMEHNRHQSLFIFQQFHELVKKLKYKEGNMFELQHEKEFKTIRQKQIKYHLYKGASNGQTAFRLAYRYDEQKDRLYANYLWLDHKRYEREASQGRGLYEDWSEFFDITNDLMTVVK
>NZ_CP012712.1|WP_003250597.1|2538532_2539516_+|NAD-dependent-epimerase
MQNNAKYIFITGCAGFIGFHLTKRLLDEGFSVLGMDDMNDYYDTSLKYDRLKIVMKHPHFRFVKGSIENIELLEKLFSQYDVDTVVNLAAQPGVRYSLKNPHKYIQANVVGFANILECCKKHKIRHLIYASSSSVYGNNKNAPFSVADRTDSPVSLYAATKKANELMAYTYSHLYRLPTTGLRFFTVYGPWGRPDMALFKFANAIVKQQPIEIYNYGNMKRDFTYVDDVTESILRLIDKGPSTESPYKIYNIGNNQPVQLNYFIEVLEEHLGKKAIKKLLPMQPGDVPETFADIDELVKDINYKPKVSIEEGIKRFVEWFKDYYKIN
>NZ_CP012712.1|WP_042385319.1|2537061_2538393_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MNIAMIGAGYVGTATSVAFAEYGHKVYVIERDWEKLKKLKMSVLPFFEEGMEELFKKHSANGNLLFFHYIEEVIDQCEILMITVGTPSLPNGEADLSYVEEAARQIGRSMNEYKAIVIKSTVPVGTGDKINKIIKTELKKRNKEISFDLISNPEFLREGKALQDALHPERIVIGCETEKARQVMKELYSGINSPILFTTVKDAEMIKYASNAFLATKISFINELARLCDKVGANVIQVAKGMGLDSRIGPQFLQAGIGFGGSCFPKDVKALLALASAEKTPLQILQAVLDVNETQAQWFMEKVKKALGSLSRKRIAVLGLTFKPQTDDIREASSLKIIHYLLQNNACITAYDPQGTEHVKKIYPTINYAKTTLEALNGADAALIVTEWKEIIEIDWKKAKSILSQPFVFDGRNCLDASVMLELGYHYEGVGTPNLDERINGSF
>NZ_CP012712.1|WP_042385318.1|2535071_2536529_+|glycosyltransferase-family-4-protein
MKILMICTEKLPVPPVRGGAIQTYISGVLPYLSKHHDITVLGISDPSLPDQETLDGVHYVRVPGKIFEIYREGVVRYIESNSFDLIHIFNRPRLVLPVRQAAPHAKITLSMHNDMFNIEKIDPEEATAVLEEVSSIVTVSNYVGNVIRQLYPQASPKIRTIYSGVDTERFLPGSHPKMQETRKEIRKAHGLENKTVILFAGRLSRNKGVDKLVRALPELSKKFKDLALVIVGSNWFSQNNVTDYVAYVRALAKKVPVPVVTTGFVAPDEIQNWFAAADLFVCTSQWQEPLARVHYEAMAAGLPIVTTARGGNPEVIFSEENGLVVENPEDPSNFAEKIAKILFDKSLMKKMGERGRELAVSRYKWERVASELLEVWNQAVHMTSTTAVEQDSTDKTNQTGAKELEYVIEHNSETKKEDEKAAMEQDSAEKISEDEVNNTEVEEPESVARIKIIDVDEETIRNSIWFSSTYKRGRKRNNRRGRKGS
>NZ_CP012712.1|WP_035502040.1|2554042_2554225_+|DUF255-domain-containing-protein
MKEYLERERYNEKYNWLVMSKSPYLKQHETNPVNWLEWSPEAFQKAKREGKPVFLSIGYS
>NZ_CP012712.1|WP_042385336.1|2554293_2556174_+|thioredoxin-domain-containing-protein
MAHESFEDEEVAKILNEKYISIKVDREERPDIDSVYMRVCQMMTGQGGWPLSVFLTPEGKPFYAGTYFPKQSRYGRPGFIELLTRLYDKYKENPDEIVHVAEQVTEALRQSARASGTERLPFAAIEKAYRQLLNGFDAVYGGFGGAPKFPIPHMLMFLMRYYQWKRDDRALLMVEKTLNGMANGGIYDHIGYGFARYSTDAMWLVPHFEKMLYDNALLVIVYTEAYQLTKKERYKEIAEQIIEFVKREMTSQDGAFYSAVDADSEGVEGKYYVWTPDEVVNVLGAELGELYCRVYDITEEGNFAGKNVPNLIHARMERIARRYRLTEEELRERLEEARKQLLAERSSRVRPHVDDKILTAWNALMIAALAKAAKVYERRDYLQMAKQALSFIETRLWQNGRLMVRYRGGEAKHLGIIDDYAYLVWAYVEMYEATLDLAYLQKAKTCVERMISLFWDEKHGAFFMTGNDAEALIIREKEIYDGALPSGNSVAAVQMIRLARLTGDLALLEKAETMYKVFRRQVEAYESGHTFFLQGLLLIETPAAEVVLFGKQGDEKREQFILKWQHAFAPNVFLLVAEHPADVAGIAPFAAEYEPLGDETTVYVCENFACQQPTTDVEFVAEQLFE
>NZ_CP012712.1|WP_003250592.1|2556245_2556665_+|CoA-binding-protein
MPITNPSREEIGEILRKAKRIAVVGLSDNPERTSYTVAKAMKDAGYEIIPVNPMIEEWEGIKAVKKLTDIDGHVDIVNVFRRSEHLPEIAREFVQIDADVFWAQLGVVNEEAYEFLKEKGYTVVMDRCIKVEHALTQQH
>NZ_CP012712.1|WP_003250590.1|2556821_2558792_+|DNA-topoisomerase-IV-subunit-B
MTKPSVYEYNDDAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGYGNYILVKIHKDNSVTVLDEGRGMPTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIHRDGFIYQQRFENGGKPVTTLEKIGTTNKTGTIIQFKPDPAIFSTTTFNYETLSERLRESAFLLKGLKIELIDERTGMSDVFHYENGIKAFVEYLNEDKDVLHPVVYFEGEQNGIEVEFAFQFNDGYSENVLSFVNNVRTKDGGTHEAGAKTAMTRVFNEYARKNGLLKEKDKNLEGTDIREGLSAIVSVRIPENLLQFEGQTKGKLGTSEARSAVDAIVSEHLTYFLQENPDVSTMLIKKAIRAYQAREAARKAREEARSGKKRKGKETVLSGKLTPAQSRNPQKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADILKNEEINTIIHAIGGGVGPDFSLDDINYDKVIIMTDADTDGAHIQVLLLTFFYRYMRPLIEAGKVYIALPPLYKVSKGSGKKEIVEYAWTDAQLKEITKKLGKGYTVQRYKGLGEMNAEQLWETTMNPETRTLIRVRIEDAARAERRVTTLMGDKVEPRRKWIEANVAFGLEDDPNILDNEHVFIAGGDY
>NZ_CP012712.1|WP_003250589.1|2558791_2561236_+|DNA-topoisomerase-IV-subunit-A
MAERLLDLPLEDVLGDRFGRYSKYIIQERALPDARDGLKPVQRRILYAMYIDGNTADKPFRKAAKTVGNVIGNFHPHGDSSVYEAMVRMSQDWKLRNILIEMHGNNGSIDGDPPAAMRYTEARLSSIALELLRDIEKQTVEFVPNFDDTTNEPVVLPAMFPNLLVNGSTGISAGYATEIPPHHLGEVIDAVIMRIDKPKCTVDELMTVIQGPDFPTGGIIQGKDGIKKAYETGKGKIIIRGKAAIEQGKGGKKQIIITELPYEVNKANLVKKIDELRFDKKLDGIADVRDETDRTGLRIVIELKKDADAEGILNYLYKNTDLQVPYSFNMVAIHERRPKLLSLPELLDAYIEHRKEVVTNRSQYELKKAYERQHIVEGLMKALSILDEVIATIRASRDKRDAKDNLIAKYEFTEAQAEAIVSLQLYRLTNTDITALQQEAEQLEKTIQELTTILNSEKKLLAVIKRELKAMKKQYADERRTVIEDEIEELKINLEVMIPSEDVIVTVTKEGYVKRTSYRSYNASNGQDFGMKESDRLLSQMEMNTTDVLLLFTRKGNYLYCPVYELPDIRWKDVGQHISNLIPLDRDDDLIAAVPVKRFDEPLSLVFVTKQGMVKRTELAQYKVQRYTRPLVAINVKEGDEVIHVHATDGQQSLLLITNQGYGLWFDEAEISMVGVRAAGVKGINLKEGDHVVSAHPIVAEGEQYLVIVTQRGAIKKMPLSEFTKTSRAKRGVVMLRELKTNPHRIVASVLTDKNDEMLFIRTETGEIETLSVSSLRVADRYSNGSFIIDSDEAGNVIDMWKQPFNILGKEEMR
>NZ_CP012712.1|WP_003250588.1|2561232_2561598_+|PilZ-domain-containing-protein
MKFKRQEAFRYQFGQPLPCTFRLVHDDEKYIEIEEKNAHIHDISPRGMKLETPARIPCERGQEIEIIFTLNDVEFCFLGKIVWERPFARMHYYGVRLLISNEQGEKLISEIKRHAALHRKR
>NZ_CP012712.1|WP_003250587.1|2561637_2562309_-|MerR-family-transcriptional-regulator
MKSYTLREAAKKVEVAPRILKQWEKEFAQYITVPRTKQGARIYNDELLEQFTKIKQWFSEKKTKHDIIQYLQEEQQNTGAGGEAIDAPHPLRHDSHYIAEQLAKTMKEEIVGELKKETTEAVQQAVAEMKIYMEEICENSAATKQEIHQSLARYTKTLQEETEEIHEHLDNVVTFLQEEKEKQRRYEEQILEREKAFRELVLSFRQTAASTNAKRSNKWWKFW
>NZ_CP012712.1|WP_003250585.1|2562557_2563976_+|PTS-system-trehalose-specific-EIIBC-component
MGAYEQSVAKIVEAIGGKENIVAATHCVTRLRFALKDEGKVNKEALESIDIVKGSFSANGQFQVVIGQGLVDKVYNELVEMTGIGRATKQEIKDAAEAKLNPLQRAIKILADIFIPILPAIVTAGLLMGINNILTGPDIFYEGKSFVEVHKEWADFANMINLIANTAFVFLPGLIGWSAVTKFGGSPLLGIVLGLMLVHPDLLNAWGWGAAKEKGEIPIWNLFGFEVQKVGYQGQVLPVLVAAYVLAKIEQFLRKRIPDAFQLLLVAPIALLITGFLAFIAIGPITFAIGNAITHVFVSVFDNVPAIGGFLYGALYAPLVVTGMHHTFLPVDLQLIANTGGTFLWPILVMSNIAQGSAALAMMFVAKDEKLKGLSFTSAVSAYLGITEPAMFGVNLRFRYPFISAMTGAAIAGMFITLNKVIAPSIGVGGLPGFLSIVPQKWVPFFIGMAIAIIVPFVLTFVFSKFRKEESR
>NZ_CP012712.1|WP_013400877.1|2564089_2565778_+|alpha,alpha-phosphotrehalase
MQHPWWKKAVVYQIYPKSFNDTNGDGIGDLAGIIEKLDYLKQLGVDVIWLTPIYKSPQRDNGYDISDYFQIHDEYGTMEDFDRLLEEVHRRGMKLIMDMVVNHTSTEHEWFKQARTSKDNPYRNFYIWRDPKPDGSAPTNWQSKFGGSAWEYDEKTGQYYLHLFDVTQADLNWENEELRRRIYDMMHFWFQKGVDGFRLDVVNLLSKDQRFLDDDGSMPPGDGRKFYTDGPRIHEFLHEMNQEVFSKYDVMTVGEMSSTTIDHCIKYTNPERRELNMVFNFHHLKVDYPNGEKWAVADFDFLALKRILSEWQVEMHKGGGWNALFWCNHDQPRIVSRYGDDGKYHKESAKMLATVIHMMQGTPYIYQGEEIGMTDPKFERIDDYRDVESLNMYHILREQGKSEQEVLEILKRKSRDNSRTPMQWDDSENAGFTTGKPWIRVAPNYQQINVKKALEDPTSVFYHYQRLIQLRKQYDIITTGDYQLLLEDHPDIFAYLRNGENEKLLVVNNFYGRETTFILPDDVAVNGYASEILISNYDDSPSDFRKITLRPYESIVYYLTKS
>NZ_CP012712.1|WP_035502036.1|2565801_2566515_+|trehalose-operon-repressor
MYENKYLTIYHDLAGKIRQGYWKPYDKLPSENELVKRYRTSRETIRKALNLLSEHGYIQKMKGKGSLVLDVGKYDFPVSGLVSFKELAQNMKQPVKTIVNELEVIKPDPDLKRYLHATSKDEIWKVIRSREIEGERIILDKDFFYKKYVPTLTREICEDSIYEYLEKQLKLKISFAKKEMTVEKVNDEDRKYLDLNGYDHIVVVKNFVYLDDATLFQYTESRHRLDKFRFVDFARRK

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Crispr_ID: NZ_CP012712_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012712_10

2854698-2854794

Orphan

Consensus_repeat	Method
TCCCTGAACATCTAATACTTTCATTGCTTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012712_10

>merge|NZ_CP012712|10|2854698-2854794|CRISPRCasFinder
TCCCTGAACATCTAATACTTTCATTGCTTTCCAGAATGCCCCTGATGTTTTTTCGGATCCACCTTGTCCCTGAACATCTAATACTTTCATTGCTTTC

>NZ_CP012712|10|10|2854698-2854794|CRISPRCasFinder
TCCCTGAACATCTAATACTTTCATTGCTTTC	CAGAATGCCCCTGATGTTTTTTCGGATCCACCTTG
TCCCTGAACATCTAATACTTTCATTGCTTTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012712.1\|WP_072000129.1\|2848435_2848549_-\|YjcZ-family-sporulation-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_003250106.1\|2853761_2854235_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_045844675.1\|2854846_2855131_-\|YwqI/YxiC-family-protein	unknown	unknown	gnl\|CDD\|375099
NZ_CP012712.1\|WP_003250090.1\|2860129_2860447_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379495
NZ_CP012712.1\|WP_013400684.1\|2859602_2859761_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_167542272.1\|2855153_2855297_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_013400690.1\|2850982_2851861_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP012712.1\|WP_003250115.1\|2846705_2848064_+\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|234981
NZ_CP012712.1\|WP_071880425.1\|2848581_2848680_-\|YjcZ-family-sporulation-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_013400691.1\|2849945_2850893_-\|magnesium-transporter-CorA-family-protein	unknown	unknown	gnl\|CDD\|213356
NZ_CP012712.1\|WP_148259577.1\|2847986_2848445_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_155267342.1\|2855360_2855513_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_013400686.1\|2857954_2858662_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NZ_CP012712.1\|WP_013400688.1\|2855722_2855890_-\|DUF4937-domain-containing-protein	unknown	unknown	gnl\|CDD\|374476
NZ_CP012712.1\|WP_003250108.1\|2853312_2853693_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_013400683.1\|2859855_2860014_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_003250111.1\|2852191_2852446_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_013400687.1\|2856974_2857787_-\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|350624
NZ_CP012712.1\|WP_013400685.1\|2859094_2859496_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_013400692.1\|2848886_2849822_-\|EamA-family-transporter-RarD	unknown	unknown	gnl\|CDD\|225510

Protein	Function_ID	Function_description	E-value
NZ_CP012712.1\|WP_013400686.1\|2857954_2858662_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	6.28437e-164
NZ_CP012712.1\|WP_013400690.1\|2850982_2851861_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	1.77809e-84
NZ_CP012712.1\|WP_045844675.1\|2854846_2855131_-\|YwqI/YxiC-family-protein	gnl\|CDD\|375099	pfam17279, DUF5344, Family of unknown function (DUF5344). This is a Bacterial family of unknown function. Most of the members of this family are predicted to contain a coiled-coil region.	2.33078e-19
NZ_CP012712.1\|WP_013400688.1\|2855722_2855890_-\|DUF4937-domain-containing-protein	gnl\|CDD\|374476	pfam16291, DUF4937, Domain of unknown function (DUF4937. This family consists of uncharacterized proteins around 120 residues in length and is mainly found in various Bacillus species, such as Bacillus subtilis and Bacillus amyloliquefaciens. Several members are annotated as ydbC, but the specific function of this family is unknown.	2.68837e-14
NZ_CP012712.1\|WP_013400691.1\|2849945_2850893_-\|magnesium-transporter-CorA-family-protein	gnl\|CDD\|213356	cd12822, TmCorA-like, Thermotoga maritima CorA-like family. This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.98633e-68
NZ_CP012712.1\|WP_003250115.1\|2846705_2848064_+\|MATE-family-efflux-transporter	gnl\|CDD\|234981	PRK01766, PRK01766, multidrug efflux protein; Reviewed.	0
NZ_CP012712.1\|WP_003250090.1\|2860129_2860447_-\|hypothetical-protein	gnl\|CDD\|379495	pfam14191, YodL, YodL-like. The YodL-like protein family includes the B. subtilis YodL protein, which is functionally uncharacterized. This domain family is found in bacteria, and is approximately 100 amino acids in length. There are two completely conserved residues (Y and D) that may be functionally important.	0.000226429
NZ_CP012712.1\|WP_013400687.1\|2856974_2857787_-\|M15-family-metallopeptidase	gnl\|CDD\|350624	cd14852, LD-carboxypeptidase, L,D-carboxypeptidase DacB and LdcB, and related proteins. This L,D-carboxypeptidase family includes LdcB LD-Carboxypeptidase from Streptococcus pneumoniae, Bacillus anthracis, and Bacillus subtilis, and L,D-carboxypeptidase DacB from Streptococcus pneumonia and Lactococcus lactis. These enzymes are active against cell-wall-derived tetrapeptides and synthetic tetrapeptides lacking the sugar moiety but are inactive against tetrapeptides terminating in L-alanine. L,D-carboxypeptidase DacB plays a key role in the remodeling of S. pneumoniae peptidoglycan during cell division. It adopts a zinc-dependent carboxypeptidase fold and acts as an L,D-carboxypeptidase towards the tetrapeptide L-Ala-D-iGln-L-Lys-D-Ala of the peptidoglycan stem. This family also includes vanY D-Ala-D-Ala carboxypeptidase which is vancomycin-inducible and penicillin-resistant. VanY hydrolyzes depsipeptide- and D-alanyl-D-alanine-containing peptidoglycan precursors; it is insensitive to beta-lactams. All these enzymes belong to the MEROPS family M15 subfamily B.	1.74342e-79
NZ_CP012712.1\|WP_013400692.1\|2848886_2849822_-\|EamA-family-transporter-RarD	gnl\|CDD\|225510	COG2962, RarD, Predicted permeases [General function prediction only].	2.37016e-98

>NZ_CP012712.1|WP_003250106.1|2853761_2854235_-|hypothetical-protein
MDLFTLGSQKYGIHFSKDTLLNFTYIILLIGFLIFIVTFICFYILLIKGHYRKGSRKEEQRDNMENLIKSYLPVIIAGSVGLLFVMQFLFRKLNIGFNADDIQNLIIIILGICLFFAMMVVLPEQLVLLYCKYRFEGFNFYMSGHLKELDEKSNKKF
>NZ_CP012712.1|WP_003250108.1|2853312_2853693_-|hypothetical-protein
MFKSARIDEIHVVFENCEHIEIPYKDVRYIHLDGISESIWDNNVSNADEFDLSFQKNAKYLRLMIKDKPEYKRIKEHYDITWIEFLRYGEVIERIAIQWVGDNEDINLGQTVKEENGEIDIMVSPN
>NZ_CP012712.1|WP_003250111.1|2852191_2852446_+|hypothetical-protein
MSLHWYHTCCRYHGKVVRIHDKFGNVHIGRIVHVTPTRVYIAPVGARNLGGFGYAFVGWGWGWGWGYGIALAAIAAIALIGLFW
>NZ_CP012712.1|WP_013400690.1|2850982_2851861_-|cation-transporter
MVKYVEKKWEAELGAWISIISYIILAISKLIVGSVAHSDGVKADGWNNFSDIIASVAILIGIKIAKKPRDHNHPYGHSRAENISSLVAAFMMMSIGIDVIIEGISSLFHSGAESAPEPLAAFVAIVSAFAMLAVYSFNARLAKRTNSQALAAAAKDHLSDALVSIGTVVGIAGAQVHLLWLDPLVAVLIGGMICKTAWGVFMETSHALTDGFDEHILTTYKHEIATVDGVKNVADIKARMLGNYVILEVTIHVDPHLTVVKSHEIADEVERLMKQHHNIAATHVHIEPERIP
>NZ_CP012712.1|WP_013400691.1|2849945_2850893_-|magnesium-transporter-CorA-family-protein
MLDNDVIADMNNHYAPAGKDACWLHFTKASKTDLERLLQTMSVHPLAKQRLLCGTDVPMVDEYERCLFISLFTVRSQLQIMKTQMIATEKYIISYAEEENDPFIEHVKEKLLHHREHASHPGYVLYYFLDVSTRHFLQLIDDIADRIQLLEKQVFQTPFANEIGRSIYRWKIRIHELRQIAEAQEEMMKLLQHTKFPYIHEETNPYMQDVVGRFSRITAALDKFKETLSGIFDLQLSLKSDHMNVIMKTLTLVSVIFMPMTFIAGVYGMNFAAMPELKWKYGYVYALLLMATLGISVALYFKKKGWWGENDTKEK
>NZ_CP012712.1|WP_013400692.1|2848886_2849822_-|EamA-family-transporter-RarD
MNRISEEKIGILYTAFSYLLWGILPLYWKMLESRPALEILAHRIIWSFFFMVTLLVVTRQITSWRKLVSLMAKQPKLAWGISAAAILISANWFVYIWAVNHGHVVETSLGYYINPLVSVVLGMVVLKERLNVWQWISFFLATIGVFIMTFQYGAFPWVALSLAFSFGIYGLVKKLASVDSAIGLTLETMVVTPISLIYLFVLYHHHASLLSTITIWQALLLIGAGPATAVPLLYFAKGAKRISLTMLGFLQYIAPTLTLLFGIFLFHEAFTKVHIYAFSCIWAALIIFSFSKTKWMQGWHDKIVKRNSFGI
>NZ_CP012712.1|WP_071880425.1|2848581_2848680_-|YjcZ-family-sporulation-protein
MGAAYGGGFALIVVLFILLIIVGCACIGGWGY
>NZ_CP012712.1|WP_072000129.1|2848435_2848549_-|YjcZ-family-sporulation-protein
MSYGSGGCGYGGYGYGHGFVLIVVLFILLIIVGATWC
>NZ_CP012712.1|WP_148259577.1|2847986_2848445_-|hypothetical-protein
MVLTVQSITNDHREEASQPLLPISSFFRKRGVRITYWLKRIAKRRWRKYFNEKINIAICALFPLARSSRWHAKREEMWVRKSGNRLRAWNNNEKEASYSLFFVSMNPPCSRIAFRHVMKATGGECRFSLDGNLPVAALDIKETEKEEYCPGS
>NZ_CP012712.1|WP_003250115.1|2846705_2848064_+|MATE-family-efflux-transporter
MKETMTRKEKTIQLLHIFLPVFITQVGQYAMNFADVTMSGHASSSDLAGVAIGSNLWVPVFTGMSGILLALTPIVAHHLGAKRYEQISQAVIQAIYLAIVIALVIIAGGAVTLNPILNGMDLEAKVQRIAHDYLIALAFGMIPLFLYYVLRCFIDALGQTKITMWITLTALPINILFNYLLIYGKWGFPELGGVGSGYATAITYWYSCFIAIIVVVRFRRFARFKMFQRFYRPSFAAWKELLKIGLPIGFAVFFETSIFAAVTLLMSEFHTTTIAAHQSAMNFASFLYMVPLSISMALTIAVGFEVGAKRYKDAKQYSFIGIGMAVSIAIVTSLLLYFFRGDIAKIYTDEQDVLSLTAQFLLYAMFFQFSDAVAAPIQGALRGYKDVNATFWAAFASYWCIGLPFGYILANFTAFGAFGYWIGLIAGLASGAVFLFFRLLYIQRRYRQVSVQ
>NZ_CP012712.1|WP_045844675.1|2854846_2855131_-|YwqI/YxiC-family-protein
MSGEIKIVYEEVERSITNMERATQSLEPVFPSSLGGENALDVVTRLNELMQALQQTFLAYQELLIQNEIDTRQSVQMMRRTDEEVATGISRPSH
>NZ_CP012712.1|WP_167542272.1|2855153_2855297_-|hypothetical-protein
MIEHVQFDDTLQALRNKIIQLQNEISELRSSIAYLEAKQAEMLKQQN
>NZ_CP012712.1|WP_155267342.1|2855360_2855513_-|hypothetical-protein
MSLSSLYALLREKERQLMRWQTCESQLRQCQSEFFQQEHLCTKPELTAKT
>NZ_CP012712.1|WP_013400688.1|2855722_2855890_-|DUF4937-domain-containing-protein
MRLKWIRCEVDEEKKVAFSAAQEIWRDLEGCPGFLGQILLDISPLTEESTASGCF
>NZ_CP012712.1|WP_013400687.1|2856974_2857787_-|M15-family-metallopeptidase
MKQLFQWIAVALLFLFSGCSQPNHFSSEKAADNINKVDGHAAIDKNEKKKPATDLELLLEPEYWNIVEVQNGIKVIMNPSNILALVNKEQSLPATYKPDDLVVPRVPFSFSETGVDKRYMRAEAAKALEALFAAARKDGIQLVAVSGYRSYERQKMIFAEEVKEKGEEKAIHAVALPGQSEHQTGLAMDITSPAVGYQLTTAFGETKEGKWVALHAHEYGFIIRYPKGKEAITGYQYEPWHLRYVGKKAAKVIFERNITLEEYFRIVKKM
>NZ_CP012712.1|WP_013400686.1|2857954_2858662_-|purine-nucleoside-phosphorylase
MSIHIEAKQQEIAEKILLPGDPLRAQYIAETFLEGATCYNRVRGMLGFTGTYKGHRISVQGTGMGVPSISIYVNELIQSYHVQTLIRVGTCGAIQKDVNVRDVILAMSASTDSNMNRLTFRGRDYAPTANFALLRTAYEVGAEKGLPLKVGSVFTADMFYNDEPDWETWARYGVLAVEMETAALYTLAAKFGRKALSVLTVSDHILTGEETTAQERQTTFNDMIEVALETAIRVE
>NZ_CP012712.1|WP_013400685.1|2859094_2859496_-|hypothetical-protein
MAALIVSMLLSVVSVIVLLFAKEWIERLFFRWKDIPFLHVVNVLIAGGIVAASYYTFSDIGVQLAKIKWTEQFLYVYAGAIEIVLPMYIFGYWFVRKRKEREKKYTRSKDKKVLYINEKYLARRRDDYHSKTS
>NZ_CP012712.1|WP_013400684.1|2859602_2859761_+|hypothetical-protein
MGKKHRNRINGQKKNNHIPKEALIAEETAHAKEHSAAGGRKNGPGHHDNPDS
>NZ_CP012712.1|WP_013400683.1|2859855_2860014_-|hypothetical-protein
MKKKKRDNGFPTIAPGIDDDEELNEKATKEEIARGDYTKVVTLSFDEVDPAT
>NZ_CP012712.1|WP_003250090.1|2860129_2860447_-|hypothetical-protein
MVHLFMKKMLHIKREYDITIFQTPSFGQAKGYRQVYRLTISAANHHQALSHIYRMFNVPDLLPEDYQARFMSTGDIVFIDEGLNGQTYYKLCPGGWKKVSRIHIR

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Crispr_ID: NZ_CP012712_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012712_11

3867477-3868498

Orphan

Consensus_repeat	Method
GTTTGTATCTTACCTATAAGGAATTGAAAC	PILER-CR
GTTTGTATCTTACCTATAAGGAATTGAAAC	CRISPRCasFinder
GTTTGTATCTTACCTATAAGGAATTGAAAC	CRT

15 spacers

The CRISPR arrays of NZ_CP012712_11

>merge|NZ_CP012712|11|3867477-3868498|PILER-CR,CRISPRCasFinder,CRT
GTTTGTATCTTACCTATAAGGAATTGAAACCTTCATCCAGCGTCAAGTCGTTCATTTCACTTGTCGTTTGTATCTTACCTATAAGGAATTGAAACTTGGGTGGCGCTGTCGCGCACTCCTTGACCCTCAAGTTTGTATCTTACCTATAAGGAATTGAAACTTTCACATTCCGGCGCTTTTGTTTCAAGAACAGCCTCGTTTGTATCTTACCTATAAGGAATTGAAACTCGACGGCCCCTGAATTAGATCAGCTTGGTGGTATCTCGTTTGTATCTTACCTATAAGGAATTGAAACTTCGAAGAAATGATTTCTTTGCTATTCCGGCTCTCGTTTGTATCTTACCTATAAGGAATTGAAACAGAATATCCATTGAGTAATTGCACTCGACCATGATGTTTGTATCTTACCTATAAGGAATTGAAACCACTATTTTTTGTTATTTCGAGTTGAGCAGCTGTTGTGTTTGTATCTTACCTATAAGGAATTGAAACATGAAAGCACCTTCTTTAGAACGCGACGCTCTCATCGTTTGTATCTTACCTATAAGGAATTGAAACGAAGTAATTAGTCAAGCAATTAGGTGGCAAGGCATGTGTTTGTATCTTACCTATAAGGAATTGAAACTCACGTTTCGAGATATGAGAAAAGAACACGGTCATTTGTTTGTATCTTACCTATAAGGAATTGAAACTGAAGCACCTTGGCGTGAAGAGAAAGTTAAAAAAGGTTTGTATCTTACCTATAAGGAATTGAAACTGACTTCTGCCAAAATCGCTCTATCCTCATTGGCTTGTTTGTATCTTACCTATAAGGAATTGAAACCAGGCGCAGCGAACGCCTTATAGGCACAGCGAACGCCGTTTGTATCTTACCTATAAGGAATTGAAACTCAAGCCGGCCGATTCGCATTCTTTTGGCGGACGAGGTTTGTATCTTACCTATAAGGAATTGAAACTAAACTCAGTAATGTCTGGCTGCCAATCTGCAAGCAGTTTGCATCTTACCTATAAGGATTAAAACC

>NZ_CP012712|11|7|3867477-3868432|PILER-CR
GTTTGTATCTTACCTATAAGGAATTGAAAC	CTTCATCCAGCGTCAAGTCGTTCATTTCACTTGTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTGGGTGGCGCTGTCGCGCACTCCTTGACCCTCAA
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTTCACATTCCGGCGCTTTTGTTTCAAGAACAGCCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCGACGGCCCCTGAATTAGATCAGCTTGGTGGTATCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTCGAAGAAATGATTTCTTTGCTATTCCGGCTCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	AGAATATCCATTGAGTAATTGCACTCGACCATGAT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CACTATTTTTTGTTATTTCGAGTTGAGCAGCTGTTGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	ATGAAAGCACCTTCTTTAGAACGCGACGCTCTCATC
GTTTGTATCTTACCTATAAGGAATTGAAAC	GAAGTAATTAGTCAAGCAATTAGGTGGCAAGGCATGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCACGTTTCGAGATATGAGAAAAGAACACGGTCATTT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TGAAGCACCTTGGCGTGAAGAGAAAGTTAAAAAAG
GTTTGTATCTTACCTATAAGGAATTGAAAC	TGACTTCTGCCAAAATCGCTCTATCCTCATTGGCTT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CAGGCGCAGCGAACGCCTTATAGGCACAGCGAACGCC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCAAGCCGGCCGATTCGCATTCTTTTGGCGGACGAG
GTTTGTATCTTACCTATAAGGAATTGAAAC

>NZ_CP012712|11|11|3867477-3868498|CRISPRCasFinder
GTTTGTATCTTACCTATAAGGAATTGAAAC	CTTCATCCAGCGTCAAGTCGTTCATTTCACTTGTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTGGGTGGCGCTGTCGCGCACTCCTTGACCCTCAA
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTTCACATTCCGGCGCTTTTGTTTCAAGAACAGCCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCGACGGCCCCTGAATTAGATCAGCTTGGTGGTATCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTCGAAGAAATGATTTCTTTGCTATTCCGGCTCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	AGAATATCCATTGAGTAATTGCACTCGACCATGAT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CACTATTTTTTGTTATTTCGAGTTGAGCAGCTGTTGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	ATGAAAGCACCTTCTTTAGAACGCGACGCTCTCATC
GTTTGTATCTTACCTATAAGGAATTGAAAC	GAAGTAATTAGTCAAGCAATTAGGTGGCAAGGCATGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCACGTTTCGAGATATGAGAAAAGAACACGGTCATTT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TGAAGCACCTTGGCGTGAAGAGAAAGTTAAAAAAG
GTTTGTATCTTACCTATAAGGAATTGAAAC	TGACTTCTGCCAAAATCGCTCTATCCTCATTGGCTT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CAGGCGCAGCGAACGCCTTATAGGCACAGCGAACGCC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCAAGCCGGCCGATTCGCATTCTTTTGGCGGACGAG
GTTTGTATCTTACCTATAAGGAATTGAAAC	TAAACTCAGTAATGTCTGGCTGCCAATCTGCAAGCA
GTTTGCATCTTACCTATAAGGATTAAAACC

>NZ_CP012712|11|7|3867477-3868498|CRT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CTTCATCCAGCGTCAAGTCGTTCATTTCACTTGTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTGGGTGGCGCTGTCGCGCACTCCTTGACCCTCAA
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTTCACATTCCGGCGCTTTTGTTTCAAGAACAGCCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCGACGGCCCCTGAATTAGATCAGCTTGGTGGTATCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TTCGAAGAAATGATTTCTTTGCTATTCCGGCTCTC
GTTTGTATCTTACCTATAAGGAATTGAAAC	AGAATATCCATTGAGTAATTGCACTCGACCATGAT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CACTATTTTTTGTTATTTCGAGTTGAGCAGCTGTTGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	ATGAAAGCACCTTCTTTAGAACGCGACGCTCTCATC
GTTTGTATCTTACCTATAAGGAATTGAAAC	GAAGTAATTAGTCAAGCAATTAGGTGGCAAGGCATGT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCACGTTTCGAGATATGAGAAAAGAACACGGTCATTT
GTTTGTATCTTACCTATAAGGAATTGAAAC	TGAAGCACCTTGGCGTGAAGAGAAAGTTAAAAAAG
GTTTGTATCTTACCTATAAGGAATTGAAAC	TGACTTCTGCCAAAATCGCTCTATCCTCATTGGCTT
GTTTGTATCTTACCTATAAGGAATTGAAAC	CAGGCGCAGCGAACGCCTTATAGGCACAGCGAACGCC
GTTTGTATCTTACCTATAAGGAATTGAAAC	TCAAGCCGGCCGATTCGCATTCTTTTGGCGGACGAG
GTTTGTATCTTACCTATAAGGAATTGAAAC	TAAACTCAGTAATGTCTGGCTGCCAATCTGCAAGCA
GTTTGCATCTTACCTATAAGGATTAAAACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012712.1\|WP_167542277.1\|3863874_3865212_-\|purine/pyrimidine-permease	unknown	unknown	gnl\|CDD\|183124
NZ_CP012712.1\|WP_013400088.1\|3871776_3872010_+\|DUF378-domain-containing-protein	unknown	unknown	gnl\|CDD\|377214
NZ_CP012712.1\|WP_013876330.1\|3856151_3857024_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NZ_CP012712.1\|WP_042385152.1\|3852027_3852744_-\|alanyl-tRNA-editing-protein	unknown	unknown	gnl\|CDD\|225427
NZ_CP012712.1\|WP_013400094.1\|3861838_3862096_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012712.1\|WP_013400090.1\|3865487_3865673_-\|H-type-small-acid-soluble-spore-protein	unknown	unknown	gnl\|CDD\|377962
NZ_CP012712.1\|WP_003248362.1\|3870459_3871623_-\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341466
NZ_CP012712.1\|WP_013876329.1\|3857044_3858505_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143469
NZ_CP012712.1\|WP_013400093.1\|3862156_3862645_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_CP012712.1\|WP_042385159.1\|3860776_3861718_+\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NZ_CP012712.1\|WP_003248361.1\|3872047_3872413_-\|general-stress-protein-13	unknown	unknown	gnl\|CDD\|181215
NZ_CP012712.1\|WP_013876331.1\|3853250_3855074_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|372624
NZ_CP012712.1\|WP_042385154.1\|3858653_3859418_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407

Protein	Function_ID	Function_description	E-value
NZ_CP012712.1\|WP_167542277.1\|3863874_3865212_-\|purine/pyrimidine-permease	gnl\|CDD\|183124	PRK11412, PRK11412, uracil/xanthine transporter.	2.5744e-62
NZ_CP012712.1\|WP_013400088.1\|3871776_3872010_+\|DUF378-domain-containing-protein	gnl\|CDD\|377214	pfam04070, DUF378, Domain of unknown function (DUF378). Predicted transmembrane domain of unknown function. The majority of the family have two predicted transmembrane regions.	3.72143e-26
NZ_CP012712.1\|WP_013876330.1\|3856151_3857024_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	9.56153e-26
NZ_CP012712.1\|WP_042385152.1\|3852027_3852744_-\|alanyl-tRNA-editing-protein	gnl\|CDD\|225427	COG2872, COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only].	3.51017e-87
NZ_CP012712.1\|WP_003248361.1\|3872047_3872413_-\|general-stress-protein-13	gnl\|CDD\|181215	PRK08059, PRK08059, general stress protein 13; Validated.	6.72299e-64
NZ_CP012712.1\|WP_013400090.1\|3865487_3865673_-\|H-type-small-acid-soluble-spore-protein	gnl\|CDD\|377962	pfam08141, SspH, Small acid-soluble spore protein H family. This family consists of the small acid-soluble spore proteins (SASP) of the H type (sspH). SspH are unique to spores of Bacillus subtilis and are expressed only in the forespore compartment during sporulation of this organism. The sspH genes are monocistronic and are recognized by the forespore-specific sigma factor for RNA polymerase - sigma-G. The specific role of this protein is unclear but is thought to play a role in sporulation under conditions different from that of the common laboratory tests of spore properties.	2.55553e-19
NZ_CP012712.1\|WP_003248362.1\|3870459_3871623_-\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341466	cd08187, BDH, Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process. The butanol dehydrogenase (BDH) is involved in the final step of the butanol formation pathway in anaerobic micro-organism. Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process. Activity in the reverse direction is 50-fold lower than that in the forward direction. The NADH-BDH has higher activity with longer chained aldehydes and is inhibited by metabolites containing an adenine moiety. This protein family belongs to the so-called iron-containing alcohol dehydrogenase superfamily. Since members of this superfamily use different divalent ions, preferentially iron or zinc, it has been suggested to be renamed to family III metal-dependent polyol dehydrogenases. This family also includes E. coli YqhD enzyme, an NADP-dependent dehydrogenase whose activity measurements with several alcohols demonstrate preference for alcohols longer than C3. The active site of YqhD contains a Zn metal, and a modified NADPH cofactor bearing OH groups on the saturated C5 and C6 atoms, possibly due to oxygen stress on the enzyme, which would functionally work under anaerobic conditions.	0
NZ_CP012712.1\|WP_013876329.1\|3857044_3858505_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143469	cd07151, ALDH_HBenzADH, NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like. NADP+-dependent, p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid and other related sequences are included in this CD.	0
NZ_CP012712.1\|WP_013400093.1\|3862156_3862645_-\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	2.03628e-56
NZ_CP012712.1\|WP_042385159.1\|3860776_3861718_+\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	1.05151e-21
NZ_CP012712.1\|WP_013876331.1\|3853250_3855074_-\|APC-family-permease	gnl\|CDD\|372624	pfam13520, AA_permease_2, Amino acid permease.	2.9131e-32
NZ_CP012712.1\|WP_042385154.1\|3858653_3859418_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	3.02303e-65

>NZ_CP012712.1|WP_013400090.1|3865487_3865673_-|H-type-small-acid-soluble-spore-protein
MDINRVKQIVSSPADIPVYYNGVSVWIDDYNEQEETATIHLRDGHLREQREVPVEELTEKQ
>NZ_CP012712.1|WP_167542277.1|3863874_3865212_-|purine/pyrimidine-permease
MRQVISSLQWFLFIISGSIVVPVTVASLYQLETADAMAFISRTFFVLAVAGLLQTAFGHRLPLNEGPAGIWWGIFILYASFGVALYGTRAETLRVLESALIMSGILFMLLSLLGIVDRLARLFTPTVTGTYLLLLAVQLSGSFLKGLLGVDETGKVSIVVAALSTIIIFLSLWMTNHPVLRQFSIIVSMITGWILFRLFGFAPSIHWTEKWFEFPKWFAFGPPRWEWGIVPTAFFVTLLLLTNMLASVKVVESVMKAEKANAGNPSPKRAGFMMGISHMISGVLAAIGSVPISGAASFIATSKITKRLPFVIACVLIMLMSLFMPAVSLFTAMPAAVGYAAIFPMFAGMITLGLKELEQNGGWKERAEQVSLPLFTGIGVMFVPSEAFAPLPPVIASVASNGLIVGTLLSIFAGSSGRKKRGYFCIEVALLYRRGWTIHKHDARG
>NZ_CP012712.1|WP_013400093.1|3862156_3862645_-|N-acetyltransferase
MIRNANIEDLPAIVQIYNETIPSRMVTADLEPVTVESRKAWFFNHDPHTRPLWVVELDGHVRAWLSFQSFYGRPAYRHTAEISIYISGAYRGKGIGKQLLQKAVEEAPSLDIKTLLGFIFAHNEPSLRLFMRFGFETWGHLPKVAELDGIERDLLIVGKRMV
>NZ_CP012712.1|WP_013400094.1|3861838_3862096_-|hypothetical-protein
MNVMPIRLFTIQDGEGFVADAFQCPVTGNLIYKSSGTPSVIAYNALTEEQIQYLEKYGFRRMNGASAAAASSPGSSTLEELLPEQ
>NZ_CP012712.1|WP_042385159.1|3860776_3861718_+|thermonuclease-family-protein
MKKFVSALAIIVSTAIFPGNSFAHPGALDKLGGHFRKSDCTYLLHEPTPIAMQAKDKAALAQLIKKYNSNSECVRQLTLDKIDLQGHTLGGTSSSAASSPKQSTNQSSSLQLGQKYPAKLVTCIDGDTARFMVNGREYTTRFLFIDTPESTIQVEPYGKEASRFTCSRLSRGDITLETDGSTLFDKYRRLLAWVWVGDKLLQEEIAKAGLVEDFYDYGDYKYEDRIRKAMDEAKQAGAGMYGASSSKMNSADQQTKSEGQKPDIPSPDNEQKNQQADQETTAKETSDSNTERPVFYLLVFAFIVAFFYFLSRK
>NZ_CP012712.1|WP_042385154.1|3858653_3859418_-|N-acetylmuramoyl-L-alanine-amidase
MVKIFIDPGHGGADPGAIGNGLQEKNVTLQIAVRIRDILLAEYDNVSIRMSRIGDQTVSLTERTAAANTWGADFYLSIHVNSGGGTGYEDYVYPGVGSPTTTYQKNIHEEIIKLVDFLDRGMKQANFFVLRETNMPAVLTENGFIDNANDAPKLKSSSFIENIARGHVNGIVRSFGLPKKSAGTLYKVQIGAFRVKTNADHLAAKAKAKGFNVYVIYKDGLYKVQIGAFANLENAKQLAEKAKAAGFEAIIIQE
>NZ_CP012712.1|WP_013876329.1|3857044_3858505_+|aldehyde-dehydrogenase-family-protein
MVNFKLLNKQYISGEWKDGTSNRQLIDFNPYNNEVITTFTCASLKDVDEAYRSAKEAQKKWQHTNPIEKRAVFENAVKYIEENKESIENIIIEELGGTKLKAAFEIDLVINIIKEAATYPFRMEGKILPSPVDGKENRLYRIPVGVVGVISPFNFPFFLSMKSVAPALGAGNGVVLKPHEHTPITGGTLIAKIFEEAGLPKGLLNVVITEIEEIGDGFIEHPIPKVISFTGSSKVGKHIGEVAGRHLKKVSLELGGNSALIVLDDADIDLAVSAAVFSRFTHQGQICMSANRIIVHEKVYDEFLTKYVRKVASLKCGDPRDPETIIGPLMNERQVQMIINLIETGIKEGATPILKGEVKGNIVEPVIFTDVTPDMTIAKEELFGPVVCIMKVENDQQAIEYANNSDFGLSGAIHTSNIERGAEMAKQIETGMIHINDGTINDEPIVAFGGEKNSGLGRLNGSWSLDAFTTVKWISIQHTPRKYPYS
>NZ_CP012712.1|WP_013876330.1|3856151_3857024_+|methyl-accepting-chemotaxis-protein
MEKVEEKEKTNAEDIELLDAFLKVAPYLNQLVHEDITVGIYDTEKLIVNYPAKTFSLNVKPGDPLQEGDIITNAIKQNKLLSAIVPKELFGVGLIAKAMPIHDRNGRVVGGIGIGVNMEKAMQLSEISSNLSTVMEEITATIQSMADSITELSNEITTISEKAKEAAENVGKIEGISNLVKEIADQSNLLGLNAAIEAARAGEHGKGFSIVANEVRKMANTSKQHVEEINEKTNQMKNLIKQLNDFIQSVSEESSAQSAAIEELSATMQEINTNIQVLAEIAKQNIEIEK
>NZ_CP012712.1|WP_013876331.1|3853250_3855074_-|APC-family-permease
MVSSLKRFLIGRPLKSTELGEQKLNKLKALAVLSSDALSSVAYGTEQILLVLATIGAIAFWYSLPIAIGVLILLMALILSYRQIIYSYPHGGGAYVVSKTNLGVNPGLIAGGSLLVDYILTVAVSVSAGTDAITSAFPTLHQYTVGIAIAMVVFITILNLRGINESASVLAYPVYLFVLALVILIIVGIFRIINGQVPSTLHTPVGTAVPGITLFLLLRAFASGCSALTGVEAISNAVPNFKEPAAKNAAKTLVMMGFILAFLFVGVTFLAYWYGIAPKAEETVVSQLASEVFGRSAMYYFIQGATALILILAANTGFSAFPLLAYNLASDKYMPRMYLIRGDRLGYSNGIITLGLASILVIVAFNGQTEQLIPLYAVGVFIPFTLSQTGMIVKWVREKPTGWVPKLLTNLLGAAITLTVLCIFFITKFTQVWAVLVFLPIIVFIFHQIHKHYDAVAEQLRVNPNEIPDKIEGNVVLVPVAGITKVVEQSLNYAQAIGDYVFAVYVAFDRESMLRMEGKWKKWHPDVRLVTLFSYYRDLITPISKLVDTIESKAEERNYTVTVLIPQFIPKKGWHNFLHNQSSVLLRLYLLYKKNVIVSTVPYRLHK
>NZ_CP012712.1|WP_042385152.1|3852027_3852744_-|alanyl-tRNA-editing-protein
MTRELFLEDSYKKAHHAKVIEIKEDKIILDETIFYPTGGGQPHDTGMIKQGNETFKVNKVQRENGQIVHYVDNVEKLKQGPVEILIDWDRRYKFMRYHSLLHVLAGYLYNKFGALAIGNQIFEDRARIDFQFEEPLTNEQFNEIEDEINKLIQEDHQVSIRTVSREEAERIDGSIKTVINLLPPSIKNVRLVAIGDIDEQACGGTHVKETKEIGPFQISKIKSKGQNKKRLEVTLNCT
>NZ_CP012712.1|WP_003248362.1|3870459_3871623_-|iron-containing-alcohol-dehydrogenase
MENFSFQNPTKLIFGKGQIEQLKEEIPRYGKKILLVYGGGSIKRNGLYDEVMNLLNELKVEVTELPGVEPNPRLSTVRKGVEICKTEGIEFLLAVGGGSVIDCTKAIAAGAKYDGDPWDFITKKVKVFEALPFGTVLTLAATGSEMNAGSVITNWETKEKYGWNSPATFPQFSILDPTYTLTVPRDHTVYGIVDMMSHVFEQYFHHTANTPLQDRMCEAVLRTVMEAAPKLVNDLQNYELRETILYCGTIALNGLLQMGLRGDWATHNIEHAVSAVYDIPHAGGLAILFPNWMKHVLDENVSRFAQLAVRVFDVNPEGKAERDVALEGIEKLREFWSSIGAPSRLADYGIGEESLELIADKAMANGEFGKFKKLNRDDVLAILRASL
>NZ_CP012712.1|WP_013400088.1|3871776_3872010_+|DUF378-domain-containing-protein
MNALQRIALLLTIIGAINWGLIGFFQFDLVAAIFGGQDSVLSRIIYGLVGIAGLINLALLFKPAEELGRTEPKASRT
>NZ_CP012712.1|WP_003248361.1|3872047_3872413_-|general-stress-protein-13
MSNIEVGSIVKGKVTGIQPYGVFVELDRETQGLVHISEISHGFVKNIKDYVNVGDEITVKVLSIDPHTKRASLSMRAVEEGQRNMRKRHVKVKMSLNPGFHTLKEKLQEWIEQSKKEDLSK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP012712_7	7.19\|2531181\|35\|NZ_CP012712\|CRISPRCasFinder,CRT	2531181-2531215	35	NC_009552	Geobacillus virus E2, complete genome	23291-23325	0	1.0
NZ_CP012712_7	7.19\|2531181\|35\|NZ_CP012712\|CRISPRCasFinder,CRT	2531181-2531215	35	NZ_AP022559	Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence	38187-38221	0	1.0
NZ_CP012712_8	8.32\|2543737\|35\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543737-2543771	35	NC_008376	Geobacillus phage GBSV1, complete genome	13156-13190	0	1.0
NZ_CP012712_4	4.46\|1054038\|37\|NZ_CP012712\|CRISPRCasFinder,CRT	1054038-1054074	37	NC_015665	Parageobacillus thermoglucosidasius C56-YS93 plasmid pGEOTH01, complete sequence	15913-15949	1	0.973
NZ_CP012712_7	7.52\|2531181\|37\|NZ_CP012712\|PILER-CR	2531181-2531217	37	NZ_AP022559	Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence	38185-38221	1	0.973
NZ_CP012712_7	7.52\|2531181\|37\|NZ_CP012712\|PILER-CR	2531181-2531217	37	NC_009552	Geobacillus virus E2, complete genome	23291-23327	1	0.973
NZ_CP012712_2	2.9\|355856\|37\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	355856-355892	37	NC_008376	Geobacillus phage GBSV1, complete genome	33483-33519	2	0.946
NZ_CP012712_2	2.9\|355856\|37\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	355856-355892	37	NC_009737	Bacillus virus 1, complete genome	32938-32974	2	0.946
NZ_CP012712_4	4.18\|1054037\|38\|NZ_CP012712\|PILER-CR	1054037-1054074	38	NC_015665	Parageobacillus thermoglucosidasius C56-YS93 plasmid pGEOTH01, complete sequence	15913-15950	2	0.947
NZ_CP012712_1	1.6\|10301\|35\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	10301-10335	35	NC_031245	Bacillus phage SP-15, complete genome	160495-160529	8	0.771
NZ_CP012712_8	8.26\|2543341\|37\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543341-2543377	37	NZ_CP009639	Bacillus cereus 03BB108 plasmid pBFI_1, complete sequence	16852-16888	8	0.784
NZ_CP012712_8	8.26\|2543341\|37\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543341-2543377	37	NZ_CP053963	Bacillus cereus strain FDAARGOS_802 plasmid unnamed3, complete sequence	58385-58421	8	0.784
NZ_CP012712_9	9.4\|2553398\|36\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2553398-2553433	36	NC_011880	Cyanothece sp. PCC 7425 plasmid pP742501, complete sequence	147269-147304	8	0.778
NZ_CP012712_8	8.26\|2543341\|37\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543341-2543377	37	NZ_CP024391	Borrelia miyamotoi strain Izh-4 plasmid pIzh4-lp72, complete sequence	61365-61401	10	0.73
NZ_CP012712_8	8.26\|2543341\|37\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543341-2543377	37	NZ_CP024334	Borrelia miyamotoi strain Yekat-1 plasmid pYkt1-lp72, complete sequence	60224-60260	10	0.73
NZ_CP012712_8	8.26\|2543341\|37\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543341-2543377	37	NZ_CP024317	Borrelia miyamotoi strain Yekat-6 plasmid pYkt6-lp72, complete sequence	12149-12185	10	0.73
NZ_CP012712_8	8.26\|2543341\|37\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543341-2543377	37	NZ_CP024206	Borrelia miyamotoi strain Izh-5 plasmid pIzh5-lp72, complete sequence	12154-12190	10	0.73
NZ_CP012712_8	8.26\|2543341\|37\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543341-2543377	37	NZ_CP024352	Borrelia miyamotoi strain Izh-16 plasmid pIzh16-lp72, complete sequence	12165-12201	10	0.73
NZ_CP012712_8	8.26\|2543341\|37\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543341-2543377	37	NZ_CP024372	Borrelia miyamotoi strain Izh-14 plasmid pIzh14-lp72, complete sequence	12143-12179	10	0.73
NZ_CP012712_1	1.2\|10033\|36\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	10033-10068	36	NC_022358	Sulfuricella denitrificans skB26 plasmid pSCD, complete sequence	4703-4738	11	0.694
NZ_CP012712_7	7.28\|2531783\|39\|NZ_CP012712\|CRISPRCasFinder,CRT	2531783-2531821	39	MN694485	Marine virus AFVG_250M19, complete genome	63987-64025	11	0.718
NZ_CP012712_8	8.30\|2543604\|36\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543604-2543639	36	NZ_CP014152	Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence	27857-27892	11	0.694
NZ_CP012712_8	8.30\|2543604\|36\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543604-2543639	36	NZ_CP006909	Clostridium botulinum CDC_1436 plasmid pCBG, complete sequence	102044-102079	11	0.694
NZ_CP012712_8	8.30\|2543604\|36\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543604-2543639	36	NZ_CP013684	Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence	243086-243121	11	0.694
NZ_CP012712_8	8.30\|2543604\|36\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543604-2543639	36	NZ_CP013710	Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence	6709-6744	11	0.694
NZ_CP012712_8	8.30\|2543604\|36\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543604-2543639	36	NC_010379	Clostridium botulinum B1 str. Okra plasmid pCLD, complete sequence	62150-62185	11	0.694
NZ_CP012712_8	8.30\|2543604\|36\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543604-2543639	36	NZ_CP013700	Clostridium botulinum strain AM1195 plasmid pRSJ11_1, complete sequence	198403-198438	11	0.694
NZ_CP012712_8	8.30\|2543604\|36\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543604-2543639	36	NC_025146	Clostridium botulinum plasmid pCB111 DNA, complete sequence, strain: 111	223804-223839	11	0.694
NZ_CP012712_8	8.30\|2543604\|36\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543604-2543639	36	NC_012654	Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence	139615-139650	11	0.694
NZ_CP012712_8	8.30\|2543604\|36\|NZ_CP012712\|PILER-CR,CRISPRCasFinder,CRT	2543604-2543639	36	NZ_CP031095	Clostridium botulinum strain CFSAN034200 plasmid p1_CDC51232, complete sequence	242533-242568	11	0.694

1. spacer 7.19|2531181|35|NZ_CP012712|CRISPRCasFinder,CRT matches to NC_009552 (Geobacillus virus E2, complete genome) position: , mismatch: 0, identity: 1.0

atcggtctaaccgataaactagtacaatatcgata	CRISPR spacer
atcggtctaaccgataaactagtacaatatcgata	Protospacer
***********************************

2. spacer 7.19|2531181|35|NZ_CP012712|CRISPRCasFinder,CRT matches to NZ_AP022559 (Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence) position: , mismatch: 0, identity: 1.0

atcggtctaaccgataaactagtacaatatcgata	CRISPR spacer
atcggtctaaccgataaactagtacaatatcgata	Protospacer
***********************************

3. spacer 8.32|2543737|35|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NC_008376 (Geobacillus phage GBSV1, complete genome) position: , mismatch: 0, identity: 1.0

agatcaaccctcgcgatagtgatgcggtcaatctg	CRISPR spacer
agatcaaccctcgcgatagtgatgcggtcaatctg	Protospacer
***********************************

4. spacer 4.46|1054038|37|NZ_CP012712|CRISPRCasFinder,CRT matches to NC_015665 (Parageobacillus thermoglucosidasius C56-YS93 plasmid pGEOTH01, complete sequence) position: , mismatch: 1, identity: 0.973

tccgaacgatagctttccgacactttgccgatggcac	CRISPR spacer
tccaaacgatagctttccgacactttgccgatggcac	Protospacer
***.*********************************

5. spacer 7.52|2531181|37|NZ_CP012712|PILER-CR matches to NZ_AP022559 (Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence) position: , mismatch: 1, identity: 0.973

atcggtctaaccgataaactagtacaatatcgatagt	CRISPR spacer
atcggtctaaccgataaactagtacaatatcgatatt	Protospacer
*********************************** *

6. spacer 7.52|2531181|37|NZ_CP012712|PILER-CR matches to NC_009552 (Geobacillus virus E2, complete genome) position: , mismatch: 1, identity: 0.973

atcggtctaaccgataaactagtacaatatcgatagt	CRISPR spacer
atcggtctaaccgataaactagtacaatatcgatatt	Protospacer
*********************************** *

7. spacer 2.9|355856|37|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NC_008376 (Geobacillus phage GBSV1, complete genome) position: , mismatch: 2, identity: 0.946

attttgcgaaccatgtttattttagccgagctgcttt	CRISPR spacer
attttgcgaaccatgtttattttagctgaactgcttt	Protospacer
**************************.**.*******

8. spacer 2.9|355856|37|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NC_009737 (Bacillus virus 1, complete genome) position: , mismatch: 2, identity: 0.946

attttgcgaaccatgtttattttagccgagctgcttt	CRISPR spacer
attttgcgaaccatgtttattttagctgaactgcttt	Protospacer
**************************.**.*******

9. spacer 4.18|1054037|38|NZ_CP012712|PILER-CR matches to NC_015665 (Parageobacillus thermoglucosidasius C56-YS93 plasmid pGEOTH01, complete sequence) position: , mismatch: 2, identity: 0.947

ctccgaacgatagctttccgacactttgccgatggcac	CRISPR spacer
atccaaacgatagctttccgacactttgccgatggcac	Protospacer
 ***.*********************************

10. spacer 1.6|10301|35|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NC_031245 (Bacillus phage SP-15, complete genome) position: , mismatch: 8, identity: 0.771

attgaaatgatatgcgactggaaagctgcggtgat	CRISPR spacer
gtcgaaatgatatgtgactggaaagctgcaactct	Protospacer
.*.***********.**************...  *

11. spacer 8.26|2543341|37|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009639 (Bacillus cereus 03BB108 plasmid pBFI_1, complete sequence) position: , mismatch: 8, identity: 0.784

atacaatgttaaaagatttatatgc-attaggcatgac	CRISPR spacer
atacaatgttaaatgatttatatccaaatcggtttaa-	Protospacer
************* ********* * * * **. *.*

12. spacer 8.26|2543341|37|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053963 (Bacillus cereus strain FDAARGOS_802 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.784

atacaatgttaaaagatttatatgc-attaggcatgac	CRISPR spacer
atacaatgttaaatgatttatatccaaatcggtttaa-	Protospacer
************* ********* * * * **. *.*

13. spacer 9.4|2553398|36|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NC_011880 (Cyanothece sp. PCC 7425 plasmid pP742501, complete sequence) position: , mismatch: 8, identity: 0.778

ctcggctg--ggaaatcgacgcgaacgggatgcttgtt	CRISPR spacer
--ggggtgaaagaaatccacgcgaacgggttgcttgtc	Protospacer
   ** **  .****** *********** *******.

14. spacer 8.26|2543341|37|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024391 (Borrelia miyamotoi strain Izh-4 plasmid pIzh4-lp72, complete sequence) position: , mismatch: 10, identity: 0.73

atacaatgttaaaagatttatatgcattaggcatgac	CRISPR spacer
tttcattgttaaaagatttatatgaattaacttagaa	Protospacer
 * ** ****************** ****. .  **

15. spacer 8.26|2543341|37|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024334 (Borrelia miyamotoi strain Yekat-1 plasmid pYkt1-lp72, complete sequence) position: , mismatch: 10, identity: 0.73

atacaatgttaaaagatttatatgcattaggcatgac	CRISPR spacer
tttcattgttaaaagatttatatgaattaacttagaa	Protospacer
 * ** ****************** ****. .  **

16. spacer 8.26|2543341|37|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024317 (Borrelia miyamotoi strain Yekat-6 plasmid pYkt6-lp72, complete sequence) position: , mismatch: 10, identity: 0.73

atacaatgttaaaagatttatatgcattaggcatgac	CRISPR spacer
tttcattgttaaaagatttatatgaattaacttagaa	Protospacer
 * ** ****************** ****. .  **

17. spacer 8.26|2543341|37|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024206 (Borrelia miyamotoi strain Izh-5 plasmid pIzh5-lp72, complete sequence) position: , mismatch: 10, identity: 0.73

atacaatgttaaaagatttatatgcattaggcatgac	CRISPR spacer
tttcattgttaaaagatttatatgaattaacttagaa	Protospacer
 * ** ****************** ****. .  **

18. spacer 8.26|2543341|37|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024352 (Borrelia miyamotoi strain Izh-16 plasmid pIzh16-lp72, complete sequence) position: , mismatch: 10, identity: 0.73

atacaatgttaaaagatttatatgcattaggcatgac	CRISPR spacer
tttcattgttaaaagatttatatgaattaacttagaa	Protospacer
 * ** ****************** ****. .  **

19. spacer 8.26|2543341|37|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024372 (Borrelia miyamotoi strain Izh-14 plasmid pIzh14-lp72, complete sequence) position: , mismatch: 10, identity: 0.73

atacaatgttaaaagatttatatgcattaggcatgac	CRISPR spacer
tttcattgttaaaagatttatatgaattaacttagaa	Protospacer
 * ** ****************** ****. .  **

20. spacer 1.2|10033|36|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NC_022358 (Sulfuricella denitrificans skB26 plasmid pSCD, complete sequence) position: , mismatch: 11, identity: 0.694

ttgggtggcgctgtcgcgcactcccttgaccctcaa	CRISPR spacer
gatggttgcgctgtcgcgcgctcccttgaggtcaag	Protospacer
   *** ************.*********  .. *.

21. spacer 7.28|2531783|39|NZ_CP012712|CRISPRCasFinder,CRT matches to MN694485 (Marine virus AFVG_250M19, complete genome) position: , mismatch: 11, identity: 0.718

tggaagaaaaagatttcgaaaataaaaataaataagggc	CRISPR spacer
ataaaataaaagaattagaaaataaaaataaataactat	Protospacer
  .**. ****** ** ******************  ..

22. spacer 8.30|2543604|36|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014152 (Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence) position: , mismatch: 11, identity: 0.694

caagaaaatttgaagattggaaaaaaggatacttgc	CRISPR spacer
gtaaaaaatttgaagattggttaaaaggatctgctt	Protospacer
  *.****************  ******** . . .

23. spacer 8.30|2543604|36|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006909 (Clostridium botulinum CDC_1436 plasmid pCBG, complete sequence) position: , mismatch: 11, identity: 0.694

caagaaaatttgaagattggaaaaaaggatacttgc	CRISPR spacer
gtaaaaaatttgaagattggttaaaaggatctgctt	Protospacer
  *.****************  ******** . . .

24. spacer 8.30|2543604|36|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013684 (Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence) position: , mismatch: 11, identity: 0.694

caagaaaatttgaagattggaaaaaaggatacttgc	CRISPR spacer
gtaaaaaatttgaagattggttaaaaggatctgctt	Protospacer
  *.****************  ******** . . .

25. spacer 8.30|2543604|36|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013710 (Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence) position: , mismatch: 11, identity: 0.694

caagaaaatttgaagattggaaaaaaggatacttgc	CRISPR spacer
gtaaaaaatttgaagattggttaaaaggatctgctt	Protospacer
  *.****************  ******** . . .

26. spacer 8.30|2543604|36|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NC_010379 (Clostridium botulinum B1 str. Okra plasmid pCLD, complete sequence) position: , mismatch: 11, identity: 0.694

caagaaaatttgaagattggaaaaaaggatacttgc	CRISPR spacer
gtaaaaaatttgaagattggttaaaaggatctgctt	Protospacer
  *.****************  ******** . . .

27. spacer 8.30|2543604|36|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013700 (Clostridium botulinum strain AM1195 plasmid pRSJ11_1, complete sequence) position: , mismatch: 11, identity: 0.694

caagaaaatttgaagattggaaaaaaggatacttgc	CRISPR spacer
gtaaaaaatttgaagattggttaaaaggatctgctt	Protospacer
  *.****************  ******** . . .

28. spacer 8.30|2543604|36|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NC_025146 (Clostridium botulinum plasmid pCB111 DNA, complete sequence, strain: 111) position: , mismatch: 11, identity: 0.694

caagaaaatttgaagattggaaaaaaggatacttgc	CRISPR spacer
gtaaaaaatttgaagattggttaaaaggatctgctt	Protospacer
  *.****************  ******** . . .

29. spacer 8.30|2543604|36|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NC_012654 (Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence) position: , mismatch: 11, identity: 0.694

caagaaaatttgaagattggaaaaaaggatacttgc	CRISPR spacer
gtaaaaaatttgaagattggttaaaaggatctgctt	Protospacer
  *.****************  ******** . . .

30. spacer 8.30|2543604|36|NZ_CP012712|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031095 (Clostridium botulinum strain CFSAN034200 plasmid p1_CDC51232, complete sequence) position: , mismatch: 11, identity: 0.694

caagaaaatttgaagattggaaaaaaggatacttgc	CRISPR spacer
gtaaaaaatttgaagattggttaaaaggatctgctt	Protospacer
  *.****************  ******** . . .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

946622 : 956422

Synechococcus_phage(50.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003253332.1\|946622_947918_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	3.5e-19	35.2
WP_042384021.1\|947994_948717_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	9.2e-46	43.0
WP_013401753.1\|948709_948964_+	phosphoribosylformylglycinamidine synthase subunit PurS	A0A0E3FKD5	Synechococcus_phage	1.9e-06	38.3
WP_003253326.1\|948960_949647_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_013401752.1\|949630_951859_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.3e-169	42.5
WP_042384018.1\|951834_953247_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.6e-48	32.6
WP_042384016.1\|953261_954302_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	2.0e-70	44.1
WP_013401749.1\|954298_954868_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.9e-30	40.2
WP_042384014.1\|954883_956422_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	3.3e-77	53.0

DBSCAN-SWA_2

1523720 : 1547817

Brevibacillus_phage(40.0%)

transposase,integrase

attL 1519904:1519919|attR 1555860:1555875

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1519904:1519919	attL	NA	NA	NA	NA
WP_052518160.1\|1523720_1524035_-\|integrase	site-specific integrase	S5MNZ2	Brevibacillus_phage	2.3e-25	66.3
WP_052518158.1\|1524018_1524942_-\|integrase	tyrosine-type recombinase/integrase	S5MNZ2	Brevibacillus_phage	3.2e-43	37.6
WP_042383584.1\|1526245_1526431_+	hypothetical protein	NA	NA	NA	NA
WP_155267339.1\|1526540_1526717_+	hypothetical protein	NA	NA	NA	NA
WP_042383583.1\|1526784_1526994_+	hypothetical protein	NA	NA	NA	NA
WP_042383582.1\|1526971_1527211_+	hypothetical protein	NA	NA	NA	NA
WP_155267338.1\|1527667_1527811_+	hypothetical protein	NA	NA	NA	NA
WP_042383580.1\|1528153_1528621_+	hypothetical protein	A0A0N6W8H7	Bacillus_phage	1.1e-36	53.5
WP_072000104.1\|1528781_1529156_+	hypothetical protein	NA	NA	NA	NA
WP_042383579.1\|1529363_1529555_+	hypothetical protein	NA	NA	NA	NA
WP_042383578.1\|1529579_1530008_+	ArpU family transcriptional regulator	S6AVV9	Thermus_phage	1.6e-45	65.2
WP_042383572.1\|1531637_1532030_-	helix-turn-helix domain containing protein	NA	NA	NA	NA
WP_045844641.1\|1532210_1533449_+	hypothetical protein	NA	NA	NA	NA
WP_042383568.1\|1534031_1535309_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_157777065.1\|1535879_1536461_+	hypothetical protein	NA	NA	NA	NA
WP_042383719.1\|1536611_1537199_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_052518154.1\|1537218_1537953_+	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_052518151.1\|1537946_1538438_+	hypothetical protein	NA	NA	NA	NA
WP_042383566.1\|1538439_1539699_+	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_125010315.1\|1539941_1540364_-\|transposase	transposase	NA	NA	NA	NA
WP_155267337.1\|1540471_1540612_+	hypothetical protein	NA	NA	NA	NA
WP_003252231.1\|1540673_1540913_+	hypothetical protein	NA	NA	NA	NA
WP_042383563.1\|1540955_1541315_-	response regulator	NA	NA	NA	NA
WP_003252226.1\|1541896_1542409_+	DUF3231 family protein	NA	NA	NA	NA
WP_003250680.1\|1542785_1544021_+\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	3.4e-141	62.3
WP_035502272.1\|1544764_1545025_+	hypothetical protein	NA	NA	NA	NA
WP_042384991.1\|1545361_1546282_+	hypothetical protein	NA	NA	NA	NA
WP_003252218.1\|1546902_1547391_+	DUF1648 domain-containing protein	NA	NA	NA	NA
WP_080561277.1\|1547679_1547817_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
1555860:1555875	attR	NA	NA	NA	NA

DBSCAN-SWA_3

3186146 : 3196953

Pandoravirus(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003249589.1\|3186146_3187166_-	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	8.6e-66	41.7
WP_042384049.1\|3187158_3188685_-	anthranilate synthase component I	A0A0B5J984	Pandoravirus	1.0e-30	29.8
WP_042384172.1\|3188869_3189274_-	chorismate mutase	NA	NA	NA	NA
WP_013876725.1\|3189282_3190386_-	3-dehydroquinate synthase	E5ERI4	Ostreococcus_lucimarinus_virus	4.1e-21	24.6
WP_013876724.1\|3190385_3191552_-	chorismate synthase	A0A291AU41	Pandoravirus	1.8e-43	36.7
WP_013400511.1\|3191670_3192444_-	protein-glutamate O-methyltransferase CheR	NA	NA	NA	NA
WP_003249570.1\|3192572_3193019_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	1.4e-28	45.8
WP_013400510.1\|3193118_3194084_-	heptaprenyl diphosphate synthase component II	A0A1V0SE37	Indivirus	7.8e-08	24.4
WP_013400509.1\|3194098_3194803_-	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_003249566.1\|3194807_3195623_-	heptaprenyl diphosphate synthase component 1	NA	NA	NA	NA
WP_003249564.1\|3195713_3195938_-	trp RNA-binding attenuation protein MtrB	NA	NA	NA	NA
WP_013400508.1\|3195972_3196539_-	GTP cyclohydrolase I FolE	E7DN69	Pneumococcus_phage	2.2e-50	55.4
WP_003249561.1\|3196680_3196953_-	HU family DNA-binding protein	A0A0H3UZA0	Geobacillus_virus	1.3e-29	72.2

DBSCAN-SWA_4

3259417 : 3269220

Staphylococcus_phage(44.44%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042384113.1\|3259417_3260557_-	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	8.5e-22	34.2
WP_042384115.1\|3260750_3261662_-	superoxide dismutase	Q56AR7	Bacillus_thuringiensis_phage	6.2e-39	43.1
WP_052518169.1\|3261905_3262217_+	DUF2935 domain-containing protein	A0A2I2L551	Orpheovirus	7.5e-13	41.7
WP_013876686.1\|3262260_3262740_-	YpuI family protein	NA	NA	NA	NA
WP_003249426.1\|3262775_3263195_-	hypothetical protein	NA	NA	NA	NA
WP_003249425.1\|3263258_3263849_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	3.9e-18	39.2
WP_013876685.1\|3263835_3264606_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	3.9e-10	42.1
WP_003249423.1\|3264722_3265238_+	DUF309 domain-containing protein	NA	NA	NA	NA
WP_003249422.1\|3265250_3265598_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_042384118.1\|3265717_3266185_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	4.2e-44	63.5
WP_042384121.1\|3266257_3267451_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.6e-116	53.8
WP_042384123.1\|3267471_3268119_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.3e-43	48.8
WP_003249415.1\|3268134_3269220_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	7.0e-58	37.5

DBSCAN-SWA_5

3771273 : 3779684

Staphylococcus_phage(57.14%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003248519.1\|3771273_3772860_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	9.9e-194	63.8
WP_003248518.1\|3772888_3773131_-	DUF2584 domain-containing protein	NA	NA	NA	NA
WP_003248515.1\|3773160_3773949_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	7.9e-35	39.4
WP_003248509.1\|3774049_3775048_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_003248508.1\|3775066_3775840_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.3e-34	37.9
WP_013400212.1\|3775823_3776633_+	ABC transporter permease	NA	NA	NA	NA
WP_013400211.1\|3776647_3777109_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	1.4e-18	36.0
WP_003248503.1\|3777203_3777527_-	hypothetical protein	NA	NA	NA	NA
WP_013400210.1\|3777600_3777996_-\|holin	phage holin family protein	A0A0N7GFE6	Paenibacillus_phage	1.7e-25	47.5
WP_003248499.1\|3778120_3778561_-	DNA starvation/stationary phase protection protein	A0A0A7RTZ1	Clostridium_phage	2.2e-58	76.0
WP_003248497.1\|3778813_3779287_-	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_013400209.1\|3779453_3779684_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	4.5e-23	65.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP012712

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection