CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Prophage number
NZ_CP012862	Persicobacter sp. JZB09 plasmid JZB09-Plasmid4, complete sequence	0 crisprs	RT	0
NZ_CP012864	Persicobacter sp. JZB09 plasmid JZB09-Plasmid6, complete sequence	0 crisprs	NA	0
NZ_CP012861	Persicobacter sp. JZB09 plasmid JZB09-Plasmid3, complete sequence	0 crisprs	RT	1
NZ_CP012851	Persicobacter sp. JZB09, complete genome	2 crisprs	RT,csa3,DEDDh,cas3,cas6	2
NZ_CP012859	Persicobacter sp. JZB09 plasmid JZB09-Plasmid16, complete sequence	0 crisprs	NA	0
NZ_CP012865	Persicobacter sp. JZB09 plasmid JZB09-Plasmid7, complete sequence	1 crisprs	NA	0
NZ_CP012853	Persicobacter sp. JZB09 plasmid JZB09-Plasmid10, complete sequence	0 crisprs	NA	0
NZ_CP012857	Persicobacter sp. JZB09 plasmid JZB09-Plasmid14, complete sequence	0 crisprs	PD-DExK	0
NZ_CP012854	Persicobacter sp. JZB09 plasmid JZB09-Plasmid11, complete sequence	0 crisprs	NA	1
NZ_CP012852	Persicobacter sp. JZB09 plasmid JZB09-Plasmid1, complete sequence	0 crisprs	cas3,RT,csa3	4
NZ_CP012867	Persicobacter sp. JZB09 plasmid JZB09-Plasmid9, complete sequence	0 crisprs	NA	0
NZ_CP012858	Persicobacter sp. JZB09 plasmid JZB09-Plasmid15, complete sequence	0 crisprs	NA	0
NZ_CP012855	Persicobacter sp. JZB09 plasmid JZB09-Plasmid12, complete sequence	1 crisprs	NA	0
NZ_CP012856	Persicobacter sp. JZB09 plasmid JZB09-Plasmid13, complete sequence	0 crisprs	NA	0
NZ_CP012860	Persicobacter sp. JZB09 plasmid JZB09-Plasmid2, complete sequence	0 crisprs	Cas9_archaeal,RT,WYL,DEDDh	1
NZ_CP012863	Persicobacter sp. JZB09 plasmid JZB09-Plasmid5, complete sequence	0 crisprs	NA	0
NZ_CP012866	Persicobacter sp. JZB09 plasmid JZB09-Plasmid8, complete sequence	0 crisprs	RT	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

384495 : 475298

Bacillus_phage(20.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060686085.1\|384495_386034_-\|transposase	transposase	U5N3F9	Enterobacteria_phage	2.3e-22	27.9
WP_060689759.1\|386589_403488_-	T9SS C-terminal target domain-containing protein	NA	NA	NA	NA
WP_060689760.1\|404251_404680_+	hypothetical protein	NA	NA	NA	NA
WP_060689761.1\|404897_406457_+\|transposase	DDE transposase	NA	NA	NA	NA
WP_060689762.1\|406453_406681_+	hypothetical protein	NA	NA	NA	NA
WP_060689763.1\|406662_407334_+	hypothetical protein	NA	NA	NA	NA
WP_060689764.1\|407704_407947_-	hypothetical protein	NA	NA	NA	NA
WP_084792994.1\|408525_410409_+	hypothetical protein	NA	NA	NA	NA
WP_060689765.1\|410877_411789_-	cobalamin biosynthesis protein CobW	NA	NA	NA	NA
WP_060689903.1\|412616_413297_+	NUDIX hydrolase	G3MA14	Bacillus_virus	3.8e-33	42.6
WP_060689766.1\|413362_414196_+	phosphoribosylpyrophosphate synthetase	A0A2H5BPY9	Vibrio_phage	6.2e-46	39.5
WP_060689767.1\|414206_415676_+	nicotinate phosphoribosyltransferase	A0A218KC49	Bacillus_phage	9.6e-151	55.9
WP_060689768.1\|415775_416420_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_060689769.1\|416844_417384_-	hypothetical protein	NA	NA	NA	NA
WP_060689770.1\|417413_418001_-	hypothetical protein	NA	NA	NA	NA
WP_060685483.1\|418152_419046_+\|transposase	IS1595 family transposase	NA	NA	NA	NA
WP_060687448.1\|419592_420783_+\|transposase	transposase	NA	NA	NA	NA
WP_060689771.1\|421001_421292_+	hypothetical protein	NA	NA	NA	NA
WP_060689772.1\|421273_421471_-	hypothetical protein	NA	NA	NA	NA
WP_060689773.1\|421597_422641_-	hypothetical protein	NA	NA	NA	NA
WP_060689774.1\|422745_423072_-	hypothetical protein	NA	NA	NA	NA
WP_060689775.1\|424321_424639_-	hypothetical protein	NA	NA	NA	NA
WP_060689776.1\|424631_424865_-	hypothetical protein	NA	NA	NA	NA
WP_071932231.1\|425368_426187_+	hypothetical protein	S5W9T9	Leptospira_phage	2.3e-29	28.6
WP_084792995.1\|426186_426687_+	hypothetical protein	NA	NA	NA	NA
WP_084792996.1\|426616_427354_+	hypothetical protein	NA	NA	NA	NA
WP_060689778.1\|427644_428100_-	hypothetical protein	NA	NA	NA	NA
WP_060689779.1\|428249_429017_-	hypothetical protein	NA	NA	NA	NA
WP_060689780.1\|429374_429608_+	hypothetical protein	NA	NA	NA	NA
WP_060689781.1\|429864_431484_+	DUF3843 domain-containing protein	NA	NA	NA	NA
WP_084792997.1\|432012_433524_-	hypothetical protein	NA	NA	NA	NA
WP_060689783.1\|434130_437274_+	hypothetical protein	NA	NA	NA	NA
WP_060689784.1\|437371_438685_+	hypothetical protein	NA	NA	NA	NA
WP_060689785.1\|439127_440291_+	MFS transporter	NA	NA	NA	NA
WP_060689786.1\|440287_441187_+	ROK family protein	NA	NA	NA	NA
WP_060689905.1\|441194_442961_+	hypothetical protein	NA	NA	NA	NA
WP_060689787.1\|443201_445538_+	glycoside hydrolase family 92 protein	NA	NA	NA	NA
WP_084792998.1\|445768_449677_-	hypothetical protein	W8CYF6	Bacillus_phage	1.1e-23	30.3
WP_060689789.1\|449969_451805_-	hypothetical protein	NA	NA	NA	NA
WP_060689790.1\|451801_454555_-	hypothetical protein	NA	NA	NA	NA
WP_060689791.1\|454606_456139_-	RagB/SusD family nutrient uptake outer membrane protein	NA	NA	NA	NA
WP_060689792.1\|456148_459358_-	TonB-dependent receptor	NA	NA	NA	NA
WP_060689793.1\|459780_462159_+	beta-glucosidase	NA	NA	NA	NA
WP_084793011.1\|462151_463723_+	sulfatase	A0A2P0VMN7	Tetraselmis_virus	1.9e-16	26.8
WP_060689794.1\|463842_464772_+	alpha/beta hydrolase	A0A076YS55	Mycobacterium_phage	8.3e-07	27.5
WP_060689795.1\|464771_466166_+	hypothetical protein	A0A2K9L727	Tupanvirus	2.7e-09	21.1
WP_060689796.1\|466169_467582_+	hypothetical protein	NA	NA	NA	NA
WP_060689797.1\|467568_469203_+	hypothetical protein	NA	NA	NA	NA
WP_060689798.1\|471409_472183_-	hypothetical protein	NA	NA	NA	NA
WP_060689799.1\|472220_472940_-\|transposase	transposase	NA	NA	NA	NA
WP_060689800.1\|473218_473800_-	hypothetical protein	NA	NA	NA	NA
WP_060689801.1\|473796_474192_-	hypothetical protein	NA	NA	NA	NA
WP_060685439.1\|474329_475298_+\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	4.8e-42	37.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP012851

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012851_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012851_1

811077-811196

Orphan

Consensus_repeat	Method
GCAGGGACTCGAACCCCGAACCGCCTGCTTAGAAGGCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012851_1

>merge|NZ_CP012851|1|811077-811196|CRISPRCasFinder
GCAGGGACTCGAACCCCGAACCGCCTGCTTAGAAGGCAGGTGCTCTATCCAGTTGAGCTACTAGACCATTGTGGTGATCGCGCAGGGACTCGAACCCCGAACCGTCTGCTTAGAAGGCAG

>NZ_CP012851|1|1|811077-811196|CRISPRCasFinder
GCAGGGACTCGAACCCCGAACCGCCTGCTTAGAAGGCAG	GTGCTCTATCCAGTTGAGCTACTAGACCATTGTGGTGATCGC
GCAGGGACTCGAACCCCGAACCGTCTGCTTAGAAGGCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012851.1\|WP_060685160.1\|815713_816388_-\|energy-transducer-TonB	unknown	unknown	gnl\|CDD\|367555
NZ_CP012851.1\|WP_053406234.1\|805289_806606_-\|aspartate-kinase	unknown	unknown	gnl\|CDD\|236376
NZ_CP012851.1\|WP_060685155.1\|807958_808675_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|188247
NZ_CP012851.1\|WP_060685152.1\|801158_801488_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP012851.1\|WP_060685159.1\|814518_815193_-\|energy-transducer-TonB	unknown	unknown	gnl\|CDD\|367555
NZ_CP012851.1\|WP_060685157.1\|809886_810996_+\|DNA-replication-and-repair-protein-RecF	unknown	unknown	gnl\|CDD\|234608
NZ_CP012851.1\|WP_053406224.1\|816480_816849_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227939
NZ_CP012851.1\|WP_071932190.1\|817479_824496_-\|cell-surface-protein-SprA	unknown	unknown	gnl\|CDD\|275042
NZ_CP012851.1\|WP_053406221.1\|825415_825838_-\|secondary-thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|376651
NZ_CP012851.1\|WP_060685162.1\|825884_826772_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378965
NZ_CP012851.1\|WP_053406223.1\|816918_817296_-\|glycine-cleavage-system-protein-H	unknown	unknown	gnl\|CDD\|234918
NZ_CP012851.1\|WP_060685161.1\|824655_825249_-\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NZ_CP012851.1\|WP_053406233.1\|806696_807173_-\|6,7-dimethyl-8-ribityllumazine-synthase	unknown	unknown	gnl\|CDD\|376408
NZ_CP012851.1\|WP_060685156.1\|808742_809771_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|274473
NZ_CP012851.1\|WP_053406227.1\|813315_814200_+\|YicC-family-protein	unknown	unknown	gnl\|CDD\|236993
NZ_CP012851.1\|WP_084792831.1\|802756_804865_-\|ferrous-iron-transport-protein-B	unknown	unknown	gnl\|CDD\|223447
NZ_CP012851.1\|WP_060685153.1\|801629_801959_+\|type-II-toxin-antitoxin-system-HigB-family-toxin	unknown	unknown	gnl\|CDD\|378301
NZ_CP012851.1\|WP_053406235.1\|804869_805094_-\|ferrous-iron-transport-protein-A	unknown	unknown	gnl\|CDD\|377199
NZ_CP012851.1\|WP_060685154.1\|802103_802502_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|227786
NZ_CP012851.1\|WP_060685158.1\|811337_813191_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223953

Protein	Function_ID	Function_description	E-value
NZ_CP012851.1\|WP_060685160.1\|815713_816388_-\|energy-transducer-TonB	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	3.86573e-20
NZ_CP012851.1\|WP_053406234.1\|805289_806606_-\|aspartate-kinase	gnl\|CDD\|236376	PRK09084, PRK09084, aspartate kinase III; Validated.	5.11927e-138
NZ_CP012851.1\|WP_060685155.1\|807958_808675_-\|hypothetical-protein	gnl\|CDD\|188247	TIGR02795, Uncharacterized_protein_in_oprL_3'region, tol-pal system protein YbgF. Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.	0.000364179
NZ_CP012851.1\|WP_060685152.1\|801158_801488_+\|transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.84052e-35
NZ_CP012851.1\|WP_060685159.1\|814518_815193_-\|energy-transducer-TonB	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	2.00272e-20
NZ_CP012851.1\|WP_060685157.1\|809886_810996_+\|DNA-replication-and-repair-protein-RecF	gnl\|CDD\|234608	PRK00064, recF, recombination protein F; Reviewed.	1.54763e-108
NZ_CP012851.1\|WP_053406224.1\|816480_816849_-\|hypothetical-protein	gnl\|CDD\|227939	COG5652, COG5652, Predicted integral membrane protein [Function unknown].	2.37857e-07
NZ_CP012851.1\|WP_071932190.1\|817479_824496_-\|cell-surface-protein-SprA	gnl\|CDD\|275042	TIGR04189, gliding_motility-related_protein, cell surface protein SprA. SprA is a cell surface protein widely distributed in the Bacteroidetes lineage. In Flavobacterium johnsoniae, a species that shows gliding motility, mutation disrupts gliding.	0
NZ_CP012851.1\|WP_053406221.1\|825415_825838_-\|secondary-thiamine-phosphate-synthase	gnl\|CDD\|376651	pfam01894, UPF0047, Uncharacterized protein family UPF0047. This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.	6.8031e-63
NZ_CP012851.1\|WP_060685162.1\|825884_826772_-\|hypothetical-protein	gnl\|CDD\|378965	pfam12836, HHH_3, Helix-hairpin-helix motif. The HhH domain is a short DNA-binding domain.	1.84972e-10
NZ_CP012851.1\|WP_053406223.1\|816918_817296_-\|glycine-cleavage-system-protein-H	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	8.29465e-66
NZ_CP012851.1\|WP_060685161.1\|824655_825249_-\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	5.87907e-74
NZ_CP012851.1\|WP_053406233.1\|806696_807173_-\|6,7-dimethyl-8-ribityllumazine-synthase	gnl\|CDD\|376408	pfam00885, DMRL_synthase, 6,7-dimethyl-8-ribityllumazine synthase. This family includes the beta chain of 6,7-dimethyl-8- ribityllumazine synthase EC:2.5.1.9, an enzyme involved in riboflavin biosynthesis. The family also includes a subfamily of distant archaebacterial proteins that may also have the same function. The family contains a number of different subsets including a family of proteins comprising archaeal lumazine and riboflavin synthases, type I lumazine synthases, and the eubacterial type II lumazine synthases. It has been established that lumazine synthase catalyzes the penultimate step in the biosynthesis of riboflavin in plants and microorganisms. The type I lumazine synthases area active in pentameric or icosahedral quaternary assemblies, whereas the type II are decameric. Brucella, a bacterial genus that causes brucellosis, and other Rhizobiales have an atypical riboflavin metabolic pathway. Brucella spp code for both a type-I and a type-II lumazine synthase, and it has been shown that at least one of these two has to be present in order for Brucella to be viable, showing that in the case of Brucella flavin metabolism is implicated in bacterial virulence.	1.48536e-70
NZ_CP012851.1\|WP_060685156.1\|808742_809771_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl\|CDD\|274473	TIGR03182, Pyruvate_dehydrogenase_E1_component_subunit_alpha, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	1.01835e-179
NZ_CP012851.1\|WP_053406227.1\|813315_814200_+\|YicC-family-protein	gnl\|CDD\|236993	PRK11820, PRK11820, YicC family protein.	1.25344e-103
NZ_CP012851.1\|WP_084792831.1\|802756_804865_-\|ferrous-iron-transport-protein-B	gnl\|CDD\|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	0
NZ_CP012851.1\|WP_060685153.1\|801629_801959_+\|type-II-toxin-antitoxin-system-HigB-family-toxin	gnl\|CDD\|378301	pfam09907, HigB_toxin, HigB_toxin, RelE-like toxic component of a toxin-antitoxin system. HigB_toxin is a family of RelE-like prokaryotic proteins that function as mRNA interferases. HigB cleaves translated mRNA only, and cleavage depended on translation of the target RNAs. HigB belongs to the RelE super-family of RNases. The toxin-antitoxin gene-pair is induced by environmental stress factors.	1.29236e-25
NZ_CP012851.1\|WP_053406235.1\|804869_805094_-\|ferrous-iron-transport-protein-A	gnl\|CDD\|377199	pfam04023, FeoA, FeoA domain. This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	1.86346e-18
NZ_CP012851.1\|WP_060685154.1\|802103_802502_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|227786	COG5499, COG5499, Predicted transcription regulator containing HTH domain [Transcription].	2.51327e-11
NZ_CP012851.1\|WP_060685158.1\|811337_813191_-\|hypothetical-protein	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	2.82975e-93

>NZ_CP012851.1|WP_060685157.1|809886_810996_+|DNA-replication-and-repair-protein-RecF
MFLFNIQLLNFKNYEELNMQFSPQINCLVGENGSGKTNLLDAIHYLSLAKSVFPGQDQQSIRHQEPFFSIRGEFRNEDRQHQVLCALQQGAKKVLRCDQVPYERLSDHVGRFPVVMMAPHDTDLIREGSEERRRFFDAIICQTDRNYLQWLMEYNGLLKQRNALLRQWQKNHMPADQDLLETYNIPLLDRAAKIAQARISFLDQFEPLFQAHYQALSGGREEVSLRYRTEVLKEDFKEKFDQATEKDVVMGRTTLGVHRDDFRFLIGGHPVKRFGSQGQQKSFVVALKLSHFDLIHQQKGFKPILLLDDIFDKLDDQRMQHLLKMVAGHKFGQIFITDARPERTKGLVKEIDEEVKIFEIEKGVIQNKE
>NZ_CP012851.1|WP_060685156.1|808742_809771_-|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MSNQTANTGSAATEERFSKETYMWWYENMLHMRRFEEMSGRVYGQQKISGFCHLYIGQEACAAGAVSALKKGDKYITAYRDHAHPIALGSDPKRIMAELYGKATGLSKGKGGSMHIFDVENGFYGGHGIVGGQIPLGAGLAFAEQYKGTDNLCIAYMGDGAARQGAVHEAFNMAMTMKLPIIFVIENNGYAMGTSVQRTSNVIELYKLGESYDMPSRPVDGMSVEEVHIACEEAAEHIRAGKGPVLLEFRTYRYKGHSMSDPAKYRTKEEVESYKQKDPVQQVKATILEKGYATEEELKEMDNRIKESVKECVKFAEESPLPDPKEIFTDVYAQEDYPFVRE
>NZ_CP012851.1|WP_060685155.1|807958_808675_-|hypothetical-protein
MAKNKKKQEEAEKYTGQELLENPEAIADRLSKSEEFLEKNKVAVIGGSVALIVAVGLFFFYQSFISGKDKTAQAEMFQAQYYFEQDSLNLALNGDGNSYGFLKIADEYGSTPAGKLANYYTGVIYLRQGEFDNAINTLKGFSPSDQLIQAKTYALIGDGYMEKKSYGDALSYYQKAANYKANKFFSPIYLKKAALAAELKGDLKTAKSSLETIVNDYSDANEYQEARKQLARVNGMIN
>NZ_CP012851.1|WP_053406233.1|806696_807173_-|6,7-dimethyl-8-ribityllumazine-synthase
MATALKNLSEYSDKNLSDVSGKTFAIVVSEWNEEVTEALYKGAKETLLVNGVSEKNIIRKNVPGSYELSLGAQWMAQRADVDAVICLGCVIQGETKHFDFINQAVAIGITEVNLKFNKPVIFGVLTPDTQEQALDRAGGKHGNKGDEAAITAIKMLGF
>NZ_CP012851.1|WP_053406234.1|805289_806606_-|aspartate-kinase
MQVYKFGGTSVGRPERMHRVAELIQADSERKIVVLSALSGTTNALVAIGDALTAKNNDLARQLIEELYEHYLAFYPKLVIGDNALAKAKQIIDEHFSFIRTLPGHFFNKRLNKELLAQGELMSTKLFTTYLHEQGVKAQLLPALDFMLVNEDHEPDLDFTSRELSALVEAAEGTQLFITQGYICRDHEGEVSNLSRGGSDYTATLIGAAIQASETQIWTDIDGMHNNDPRVVENTFPIPELSFDEASELAYFGAKILHPTSIIPAQRYNVPVRLKNTMEPKAPGTLISQHFSATGAVKAVAAKDGITAIKIRSNRMVLAYGFIRQIFEVFEKYKTPIDMITTSEVAVSLTIDNDEQLPQILETLEKFGQVQVDRNQSIVCVVGDFGEEKVGIATKVLDAMEEVPIRMISYGGSDYNISLLVGSENKEKSLCRLNEFLF
>NZ_CP012851.1|WP_053406235.1|804869_805094_-|ferrous-iron-transport-protein-A
MNIADLKIGQKGIVTGFSDEELSLRLLDMGCLPGEEITLSCIAPLGDPIAIDVAGSRVSLRKKEASTVMIEKIS
>NZ_CP012851.1|WP_084792831.1|802756_804865_-|ferrous-iron-transport-protein-B
MRENILKVALIGNPNAGKTSIFNLLTGLNQKVGNFPGVTVDKKSGPCNKIKSRKVQIVDFPGTYSIYPRSADERVFFTEVTNPESDNFPDMAVVVVDAAHLKRNLLLFSQIKDMGVPAIIAMTMLDVLPEKDQLDLELLAQKLDSPIIPVNGRNGEGMEELIAEIERFEYHIPEPFLPMESYVHDDLFFRATAAFPDEHPYRVYQMMQQTDTYAGIGPEDIDIIDEIKENSSFKSHQLQAQETINRYRLLDDILREVKPHNKKIEENLRVSSQLDKILTHPLWGYFIFIGILFFMFQAIYSWASIPMDFIDEQFGALGEWISATLPDGSLNSLISEGIIPGIGGIVIFVPQIAILFAFIALLEETGYMARAVFLTDRIMRVFGLNGKSIVPLISGVACAIPAVMAARNIENWKERLITILVAPLISCSARLPVYTILIALVIPDESIGFFNLQGLVLMGLYVLGFVLALGIALIMHKIINSPQRPFLIMELPSFRMPRWKNVGLTIYEKSKTFVFSAGKIIFIISIVLWVLASYGPGSEIAQAESIVTDQYQGDNQEELENLIASYKLEHSFAGYLGKAIEPVIEPLGYDWKIGIALITSFAAREVFVGSMATIYSVGTDAENTKTVKDRLATEINPKTGLPVFNLASGISLMIFYAIAMQCMSTLAIVKRETKSWKWPMVQLAYLTGLAYVSALIAYQTLI
>NZ_CP012851.1|WP_060685154.1|802103_802502_+|helix-turn-helix-domain-containing-protein
MEALKYKIIKDREQYEDYCEQLEALLALENPELEDEIELLTFLIEKYDEEHSSFKELSPIALLRELMASHGLNQSQLGEIMGVQKSTVSKVLNLQKGLSKESIRRLADHFKLRQEAFNRPYELLNQETLKTS
>NZ_CP012851.1|WP_060685153.1|801629_801959_+|type-II-toxin-antitoxin-system-HigB-family-toxin
MRVHLIKRQTVEDYMRSNASSKAAFEAWLMAIRYADWYQPQDILSTFNSVDILGKGSDRVIFNIGGNSHRMICKYLFGRKVHLFVKWIGTHAEYDKICKKGLQYSISEF
>NZ_CP012851.1|WP_060685152.1|801158_801488_+|transcriptional-regulator
MEAEKSCGVCPLAETMEVIGSKWKPLILFHLREGAERSGILQRRVKGITNKMFTQSIRELEADGLVARKVYPVVPPKVEYMLSARGKSLLPILEQLDQWGREVLLAEKV
>NZ_CP012851.1|WP_060685158.1|811337_813191_-|hypothetical-protein
MDKNSLLDLFEKAVHAFGPQPLFWQWQEGVFSPITYQETSQHVHGYANGWKNSGLNRGEKVALWLDSSPLWVITEISIWYAGGVAVPMNLKTEINTLIWQIKHAECQHLVLEEHLVEQILPHLSALPENLHLWYNRKNQRFEHPQITPLQELLDFGDQVPLIPTTDLATIIFTSGTSADPRAVLLSHENLRTNVLQIKKRIPIPPEARTFMLLPLDHAFAHTVGLYSVIIQGGSIGFPPQGKSMMEILRMIPEILQSFQPDFLLLVPALIKSLRLYVERAVRSLGEEVEKDYRNALALAYQKARSGDELGYVKRLSAFFMTHAVLNKLKDKLFPNLKFMVTGGAYLDRNVIFYFNALGLPVYQGYGLTEAGPVVSTNNEQYQKVGSVGMPLSMIEVEIRDEKGERLPLEKTGEIVVKGTNVTRGYFKNTEATNLLIRDKWLHTGDIGKIDSEGYLYVLGRIKSLLISSDGEKFPPEMVEADIEEFCSCIDAVCLYNNQSPYTLALVVPNVANIRKKALEKHIGNKELIPFTLKTIEEELINFRKATAFEAKWTPNRFRLMMEPMSIQNRFLNHNYKMIRPRVHDFYAAEIEEIFRKKDRNTNDPKNLERASNLHVSH
>NZ_CP012851.1|WP_053406227.1|813315_814200_+|YicC-family-protein
MIKSMTGYGSANLDTESISIQVEVRTLNSKFLDTNLKLPRTFSDREIEIRNTIGDCLERGKVAVNIEFNRKDDTTPKVQVNEGLFQNYYAALKALAENTGASEQELFKLVLQMPEVLVNEREELGSEEDWKLLHSALNAALKDCDAFRLKEGAVLAEKLVSYIDVIDGCLQKVPQFEEERVETVKNRLRQNLEDLQQKEDYDQNRFEQEIIFYLEKYDINEEKVRLANHLKYFKEVILKPTQASNGKKLGFISQEIGREINTLGSKANHAAIQRLVVQMKEELEKIKEQSLNIL
>NZ_CP012851.1|WP_060685159.1|814518_815193_-|energy-transducer-TonB
MELKKDPGKDLKKRRSLFFTIGLCLSLAFSIAAFNWRVYEDKIDITGIPIDGDDIEIVEIPASRTEPPKPPRVVNPVIIEIPDTEDILDPDDIDIDIEVTETDKIEDVIFTDAPKEEDPEEIVVFVEKQPAYPGGIPAFYKYVSKNMNYPSQAKRQGISGKVFVQFVVDRDGSISNVEIMKGIGAGCDEEAKRVLANSPKWNPGKQRGRAVRVRMVLPITFKLN
>NZ_CP012851.1|WP_060685160.1|815713_816388_-|energy-transducer-TonB
MEIKKNPGKDLTKKSGLFFNIGLCISLGLVILAFEWKSYDDVKIADAAVAEVDFEEVTEVPQTQQPPPPPPKIQAPVIVEVPDEEVIDEDIDVDLDVDVTEDAVIEEVVFEEAPEEEEVEEVFTIVEDQPEFPGGMPAFYKYIGKNLKYPSQARRMGIEGKVFVQFVVGKDGKISEVQVIKGIGAGCDEEAKRVIEGSPKWKAGKQRGRAVKVRMILPITFKLG
>NZ_CP012851.1|WP_053406224.1|816480_816849_-|hypothetical-protein
MILRYQLFTIIWVIIILFLTLLPASSLPSGINWYIPFDKLAHAGVFGILALLLTIGSCKQYSVEHMKRFPYHWTISLCFVFGLLIEVLQGSFTSRHFEWMDLVADMIGAFIGLIVFFFVYKW
>NZ_CP012851.1|WP_053406223.1|816918_817296_-|glycine-cleavage-system-protein-H
MNIPAELKYTKDHEWIRIEGNTAIVGVTDFAQKELGDIVYVEVETVDEEIEAGEVFGTVEAVKTVSDLFMPISGTIVEFNESLESEPEKVNADAYGEGWMIKIEMNNPAEVETLLSAEAYEELIG
>NZ_CP012851.1|WP_071932190.1|817479_824496_-|cell-surface-protein-SprA
MRNENQKDSIPEKYVPSRTPQVNPESDRPGAPFTDPNLGLSPLYLKDPSNVKMDVELDTSNNYTIYEKMGDVNFRPTTNMTFDEFNQYNNQQIQKEYWLERSKGLDGESAVSGRQLIPPIYVSPIFDRIFGGSYIDITPSGYATLDFALRYQRVANPAVPVSQQRNGGFEFQNQISMNVIGEIGDKLKVTANFDNNKAFNFQNDFRVEYTGYKEEIIKKIEVGNVSLPSSNSLITGAQNLFGVKAQFQFGKLYATTLFSTQRGKSNTIVLEGNSGGQGKQFEMVASNYDENRHFFLGHFFKDNYENWLRGLPQVLSGVNVTRVEVYVLNRNNDTQTLRNVAGLLDMAEPNRDNMNKPDNSFNQPINPAFPNDNRANGMFNSLQQDPSLRNADTFTDAMIAKGFENSEDFVKINGARKLDPQEYSIHSALGYISLFRRLQNDEMLAVAYEYTYNGQAYKVGEMSEDYQNRPDAELIFLKMLRPNKIDVESPAWQLMMRNVYNLGSSQIGPEGFDLKVIYRDDRTGIDNPSLHEGTNTKDKPLVELLRADRLNRNGDPQPDGIFDYVADVTVFSDNGNIFFPVLQPFGNTLDEQFLPTEDVLKEKYVFEELYSRTKADAELVTEKNKFFIKGSFQAGSGSEITLPGIDISPGSVVLSAGGIPMTEGVDYTVDYNLGRVNITNQAILNSGKSITITYEQADLLNFQTRSLLGTRLDYRVDDRLNIGGTLLYLNERAVVSRVGIGDEPVRNVKYGFDVSFQDESRFLTRMVDALPLVQTKETSTVSINAEFAQLIPGTSNKVNGSGTAYIDDFETTITPFSVSNNWFLGATPETTGNRLIEDNGEDKLGINYKRAKLAWYTIDNTFYQTNSRNKPANINTEDTQNNYVRNIPPQEIFRERDETLINANIATFDMAFFPQERGPYNYNPNLTNEGLLPEPEDNWGAITRAITSDVDFDKTNIEYIEFWMMDPFIEGTNGRVLDGRLNTNNTTGGDLYFNLGSVSEDLMKDGKHAFENGLPPDGSDGGFDTNEWGKVTTQQYLNNAFDNDPNSRPFQDVGLDGLRSEEELEFFRENFIDRLVVAPEVLTAISQDPSGDNFRHYLDASYTDMDAKILERYKDFNGMDGNSPIQSNNNNFTSAGSAYPDNEDLNNDNTISDLEEYYEYKISLKPGDLEVGKNNIVDKVTNSEANASWYLFRIPVRQPSGSYGGISGFKTIRFMRTYLTGWQQPVVLRMAKFQLVGSQWRRYENSLFDNGLDEVPEPFDTDFQVSVVNLEENSSALNKIPYRVPPGISRDYDNTSVVSRQLNEQSIQLVMKDLQNKDARAVFKNTTLDLINYGRLKMFVHGQDPITQSDELRVFMRIGTDLTQNFYEIEWPLKITPEGSNTSEEIWPAENNLDIALNDLYAIKSRRNREGFEQALPYSQQVGRYKITIVGRPELSTVQTIMLGARNPDTFDKQSKDITVWFNELRATDFDSENGWAGNVRFNTKLADLGVLSGSSSYISSGFGGIQDNISARTRESSLNYDIAANVNLDKFGLDRFGLRIPMYVSYEHNKITPKWDPLDPDIPLEASLESFDTQAERDAYRKLVEDNTYRRAISFNNVRKVKVKEDAIPHIYDIENWAFSYAYSEITRTNINLADYINFNHKVGLAYNYNANPFILEPFKNSKGLKSDWLRLIKDFNLALWPSSISVRGDLDRSFIRNQLFNEDLTTVGIEPTYEKYFNFNRYYNIRWALTQNLSLTYNARAFATIDEPEGDINTQAARDSIRANLMRLGRLKTFDQNIRADYRLPLDKIPLTDFLNADLNYSVNYTWTAGPVNIEEEFDFANTIQNYRQYGGTGKIDLVKLYNKNKFLRDINKPKRKRRSSSRSTTRKIEADTIKAPAEMKGLKGMLRLLMMVRDVNATISYTDGTSLPGFEPTPNLFGQNFDNNAPGWPFILGSQDAGIRNQLADQDLLIQNGNLTQQFSQNQMINMNLNANLEPIKDLKIRLSMTKTKNSFYQELFRYDTISNSFESNTPARNGSYSISYFMLPTTFSSFDTDLVDKAFRDFESYRAIIKDRLDALNPNGGEYNINSQDVLIPAFIAAYTGKSAEEAKLSPFPKIPIPNWRLDYSGLRNIPALKDIFSSVNITHAYNSTYSVNSYTNSLEYTDNLELSNDIENYPLATKINEETGFYTPVYVLDQIVMSEQFSPLIGLNVRTKSKVSAKIEYRWERNLALNISNIQMTEMRNKDWSFDIGYTKGGMKMPFRWKGRTVVLDNDLTFRLNFVIRDTETLQRKLDDVSTITNGNVNYQIRPTVAYVVNNRLNIQAYYERTVNEPKISTSYLRTATNFGVQVRFNFSN
>NZ_CP012851.1|WP_060685161.1|824655_825249_-|Holliday-junction-branch-migration-protein-RuvA
MIAYIRGRITEKEPTYVVLDVGGLGYEVRISLNTYEKLQDNKEEVRLATYLQVKEDAHTLFGFFDILEKKLFLHLIGVNGVGANTAMVMLSSMNVRELKEAIASEDVKTIQKIKGIGAKTAQRIILELKDKLLKEGVDAPASSAGGGLAHQAKEEALIALTTLGIPKATAEKSITNILKKHGSDIGVEEIIKLALKN
>NZ_CP012851.1|WP_053406221.1|825415_825838_-|secondary-thiamine-phosphate-synthase
MKFFQHQLRLPAFRRGFHLITEEVMAHMPELSQIKVGILHVFIQHTSASLTINENADPTVRQDFEAHMNKMVPEGASYFKHTYEGPDDMPAHIKASLMGPALTIPITNGQLNMGTWQGIYLCEHRDYGGERKIIITAQGI
>NZ_CP012851.1|WP_060685162.1|825884_826772_-|hypothetical-protein
MRFFRQFQKKYNLSDRELWSVILLHLFIIIILGLGNTLPQLLKPTAIKLGIIEEITISPQLLALQKEWEKDSLFTFNPNKANTLQLHQLGFKEKSIQHLLNFRKKGYHFRLKKDLLKIADIDSLHFQKIYAYIDLPESFPKLNPKAKAKPKMAKPYSPPKKLNINLNTADKHNLSKIFGIGPKRAEQILKYRKLLGGYVEKEQLAEVYALEGETEVLKNCYQACFITPHFQPETISINQDDFKKLVRHPYLEYEEVKVICNYRREFPIENSSHLKKILSCSDRKIQKLAPYLNFD

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Crispr_ID: NZ_CP012851_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012851_2

2599345-2599437

Orphan

Consensus_repeat	Method
TTTCCTCACCCATGAATTTAATCAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012851_2

>merge|NZ_CP012851|2|2599345-2599437|CRISPRCasFinder
TTTCCTCACCCATGAATTTAATCATTGGGCCAAGCCAGAAGAAAGGATTACCACTTTAACGCCTACTATTTCCTCACCCATGAATTTATTCAT

>NZ_CP012851|2|2|2599345-2599437|CRISPRCasFinder
TTTCCTCACCCATGAATTTAATCAT	TGGGCCAAGCCAGAAGAAAGGATTACCACTTTAACGCCTACTA
TTTCCTCACCCATGAATTTATTCAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012851.1\|WP_060686374.1\|2602663_2603881_+\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|223283
NZ_CP012851.1\|WP_060686380.1\|2610548_2610893_-\|IS66-family-insertion-sequence-hypothetical-protein	unknown	unknown	gnl\|CDD\|377551
NZ_CP012851.1\|WP_060686363.1\|2589214_2589835_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012851.1\|WP_060686378.1\|2608829_2609063_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012851.1\|WP_060686379.1\|2609053_2610490_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376980
NZ_CP012851.1\|WP_060686377.1\|2607637_2608495_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378820
NZ_CP012851.1\|WP_060686368.1\|2593945_2594767_+\|DUF3298-domain-containing-protein	unknown	unknown	gnl\|CDD\|378702
NZ_CP012851.1\|WP_060686371.1\|2598825_2599320_-\|transposase	unknown	unknown	gnl\|CDD\|376616
NZ_CP012851.1\|WP_060686376.1\|2605059_2606676_-\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NZ_CP012851.1\|WP_060686373.1\|2602195_2602378_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012851.1\|WP_060686366.1\|2591436_2592102_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NZ_CP012851.1\|WP_060686369.1\|2595095_2597438_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|379720
NZ_CP012851.1\|WP_060686381.1\|2613131_2614862_-\|M1-family-peptidase	unknown	unknown	gnl\|CDD\|341066
NZ_CP012851.1\|WP_060686364.1\|2590029_2590536_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012851.1\|WP_060686365.1\|2590618_2591386_-\|S1/P1-Nuclease	unknown	unknown	gnl\|CDD\|211382
NZ_CP012851.1\|WP_060686370.1\|2597766_2598057_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376616
NZ_CP012851.1\|WP_053404943.1\|2592101_2592623_-\|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl\|CDD\|100051
NZ_CP012851.1\|WP_060686367.1\|2592657_2593944_+\|anthranilate-synthase-component-I-family-protein	unknown	unknown	gnl\|CDD\|223225
NZ_CP012851.1\|WP_060686372.1\|2599729_2601769_+\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP012851.1\|WP_084792738.1\|2604233_2604803_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112

Protein	Function_ID	Function_description	E-value
NZ_CP012851.1\|WP_060686374.1\|2602663_2603881_+\|6-phosphofructokinase	gnl\|CDD\|223283	COG0205, PfkA, 6-phosphofructokinase [Carbohydrate transport and metabolism].	1.64944e-50
NZ_CP012851.1\|WP_060686380.1\|2610548_2610893_-\|IS66-family-insertion-sequence-hypothetical-protein	gnl\|CDD\|377551	pfam05717, TnpB_IS66, IS66 Orf2 like protein. This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition.	2.55646e-39
NZ_CP012851.1\|WP_060686379.1\|2609053_2610490_-\|hypothetical-protein	gnl\|CDD\|376980	pfam03050, DDE_Tnp_IS66, Transposase IS66 family. Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.	2.94664e-91
NZ_CP012851.1\|WP_060686368.1\|2593945_2594767_+\|DUF3298-domain-containing-protein	gnl\|CDD\|378702	pfam11738, DUF3298, Protein of unknown function (DUF3298). This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.	3.65512e-14
NZ_CP012851.1\|WP_060686371.1\|2598825_2599320_-\|transposase	gnl\|CDD\|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	8.94176e-23
NZ_CP012851.1\|WP_060686376.1\|2605059_2606676_-\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	1.07274e-82
NZ_CP012851.1\|WP_060686366.1\|2591436_2592102_-\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	1.85674e-30
NZ_CP012851.1\|WP_060686369.1\|2595095_2597438_+\|TonB-dependent-receptor	gnl\|CDD\|379720	pfam14905, OMP_b-brl_3, Outer membrane protein beta-barrel family. This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.	9.77917e-41
NZ_CP012851.1\|WP_060686381.1\|2613131_2614862_-\|M1-family-peptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	2.11619e-129
NZ_CP012851.1\|WP_060686377.1\|2607637_2608495_+\|alpha/beta-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	1.8298e-11
NZ_CP012851.1\|WP_060686365.1\|2590618_2591386_-\|S1/P1-Nuclease	gnl\|CDD\|211382	cd11010, S1-P1_nuclease, S1/P1 nucleases and related enzymes. This family summarizes both S1 and P1 nucleases (EC:3.1.30.1) which cleave RNA and single stranded DNA with no base specificity. S1 nuclease is more active on DNA than RNA. Its reaction products are oligonucleotides or single nucleotides with 5' phosphoryl groups. Although its primary substrate is single-stranded, it may also introduce single-stranded breaks in double-stranded DNA or RNA, or DNA-RNA hybrids. It is used as a reagent in nuclease protection assays and in removing single stranded tails from DNA molecules to create blunt ended molecules and opening hairpin loops generated during synthesis of double stranded cDNA. P1 nuclease cleaves its substrate at every position yielding nucleoside 5' monophosphates, and it does not recognize or act on double-stranded DNA. It is useful at removing single stranded strands hanging off the end of double stranded DNA and at completely cleaving melted DNA for simple DNA composition analysis.	1.75811e-82
NZ_CP012851.1\|WP_060686370.1\|2597766_2598057_-\|hypothetical-protein	gnl\|CDD\|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	3.75057e-09
NZ_CP012851.1\|WP_053404943.1\|2592101_2592623_-\|gamma-carbonic-anhydrase-family-protein	gnl\|CDD\|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	3.14949e-75
NZ_CP012851.1\|WP_060686367.1\|2592657_2593944_+\|anthranilate-synthase-component-I-family-protein	gnl\|CDD\|223225	COG0147, TrpE, Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism].	9.36785e-114
NZ_CP012851.1\|WP_060686372.1\|2599729_2601769_+\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	4.76827e-83
NZ_CP012851.1\|WP_084792738.1\|2604233_2604803_+\|N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.12175e-31

>NZ_CP012851.1|WP_060686371.1|2598825_2599320_-|transposase
MGEFLQPGIYVRETFFLMDSMVFMSHSYSNVWIHMILVTKFRKPFIKHWLEADFHDFLKTELLNCGGKFVVINGTENHIHILYHHPLTLSISQIAKQLKGSSSRWFNQHYEVGEKFQWQVGFSVFSVSESQTDRVYHYIINQKSILLRREVEKEIEALRRLNGR
>NZ_CP012851.1|WP_060686370.1|2597766_2598057_-|hypothetical-protein
MVLINGAEPYIYILYHHPLTLSISQMAKQLKGSSSRWFNQHDEVGEKFQWQVGFSAFSVSQSQTDRVYHYIINQKSIHLRREVEKEIEALRRLNSR
>NZ_CP012851.1|WP_060686369.1|2595095_2597438_+|TonB-dependent-receptor
MKFRLPLFKLAFFLVFLFSLTVTQAQTIVSVSGQFVDSEKDEGVPFATVAIFKNKGDVNPIGSGFSEEDGSFEIILTESGTFFMQVQCMGFDGYEQALTVDISDIKLGQIPLKSQTQMLESVVITGEKVSGTSTPGAMKFNMDAQGSDDMEEIVSNMPGVEMDFDGNASIRGLSVTYLVNGEESGMENPLQEIPKQSIASIELMTNPPVEYASSGPVINIILKEDAKIGNSFRMGGNFGNLNSAKGYVGGSIRTENLTINPWVYYSQRDRETFGNNEQLNYDERFMEQSHTSKNGWRYGSAGTWWAYKFKDKSELSGTIRYSLSDNFSESWNNNDFYDLDSITFRNTNVRTNENNGFTRDFSYENKYRKTWESGQKLSLRYLMNYKESFSSQHQGSDYIYNAEEDNATILDRGDRTNDNMRHRFQARFTQPINEEMRVVTGYYFDYRKNNQTAEYDRKENQGDWIYNPDRRQDASTETMAHDVFASFTGKWDRFGLNLGMRYKMGKTDIHQWDAGMGIYDDFLNQFSNLNNTIKLSYDLKEEGENIMLSYRNNVRPPSAGQLNPFVNDANPLWITMGNPDLNSTKTHYLELEYLKVGDTYTFKGGAFGRKIFDQVARYQWSEADTIYNSYHNIEGVSVAGLNVYLQKDIVPGLRGTVDGSWSYEYMPDREGDLSKSQTYYFIKGNVEYKFAKNYRIALTGRYTSTKLSNNAQTAGYGSMDINFERKFYDGKGKVYLNIRDVLNTIEQNVLTSSDSFIRDSFAKQETRMFMLGMSFYLNGL
>NZ_CP012851.1|WP_060686368.1|2593945_2594767_+|DUF3298-domain-containing-protein
MISKPSKPINLMKNFGLIVMCLLTGLIACETKSNKEEHFEQNGLEFETLTFRVDEKDCEVEEKNACTYFEVELPYITKATLSGKEERFNQTVMDFFEEDSIKSVKEIPAFIENDMVIYEEFTEFLGDNRTKWFYSKKVDLIYTNPQLWSFHFTQEEYTGGAHGNTSHQYKVINSTTGQKLTLTDLFRPDFLPELTEMGEAAFKEARGISDSTSLSSLGFQFPKNDFELNNNFGLSEEGIRFYYNPYEIGPYSLGASFFDLPMEQIKAGLKFDI
>NZ_CP012851.1|WP_060686367.1|2592657_2593944_+|anthranilate-synthase-component-I-family-protein
MKRNQLSFPSFSEKQLLQWAASYEQLLFLNPNHYGLQEKFSHFPKMLAVGAKATLHIPEGGKAKAFEQLKAFHQKHGDWLFGHLNYDLKNEVEDLKSRHKAKTEFPDLHFFVPEHICFFEKDGVRIETYSSPSKLKEEILATKIADNPQLTKLHFHPQISQEAYLNMIDRLKEHIRQGDFYEINFCQEFIAEQADIQPVPAYWALNEMSPMPFSAFYKLKDQYAMVASPERYVKKVGHQIYSEPIKGTSRRRTDPIKDQEQINYLKTSEKEIAENMMIVDLVRNDLARTAIPGTVRVPELFEVYSFPQVHQLISTISATMASEYHWTDVLEKSFPMGSMTGAPKISVMQHADRYESGRRELYAGTLGYVSPEGDFDFNVVIRSLFYNDQKKFAHYWVGGAITIDSEAEDEYRECLLKAKAIQSIFSKN
>NZ_CP012851.1|WP_053404943.1|2592101_2592623_-|gamma-carbonic-anhydrase-family-protein
MALIKTIRGNVSPKFGKNVFLADNATVIGEVELGDNCSVWFNAVVRGDVHYIKVGDNTNIQDLACIHCSYQTHPTTIGSNVTIGHKAMIHGCTIEDNCLIGMNSVLLDGVVVKEGAIVAAGAVVLENTVVESGTIYAGIPAKKVKEIGDRKEMIQRIGENYYQKYATWYKEEE
>NZ_CP012851.1|WP_060686366.1|2591436_2592102_-|HD-domain-containing-protein
MKEDQKQQWIEQTAAYVREKFLGEGTGHDWWHIYRVWKNTKLILQGVPKANMFISEMGALLHDIADFKFHDGDETVGPRVAREYMEGLGVAEQDIAGVVHIIEHISYKGAGVENKMESIEGLVVQDADRLDAIGAIGVARTFAYGGSVGNPMHDPEQEPVLHKDFESYKNSRGSTINHFYEKLLLLKERMNTDAAKVIAEDRHAFMEDFLMRFYAEWDGKK
>NZ_CP012851.1|WP_060686365.1|2590618_2591386_-|S1/P1-Nuclease
MKKLNLVVLMMVALVGQSFGWGANGHRAVGEIAEQHLSSKARKAILALMGDENLAMASTWADEVKSDHAYDSCNVYHYVNMKGDETYERSTKNPEGDAVMALELMSSILKDPNATIEKKREAFRYIVHIVGDLHQPMHVGHAEDLGGNMVKVKWFRKDSNLHRVWDSDIINYLDLSYTELARHVGIAKEAEVKEWQSAKVLDWVEESHLIANELYDNVGEGNFGYRYVYDYKDVMYHQILKGGVRLAGYLNELFG
>NZ_CP012851.1|WP_060686364.1|2590029_2590536_+|hypothetical-protein
MNKLSLLILALFCFTACSEEPSPSITADLLESREAWENFKKEHANTYSFTSTTSSFTSLQTASTLIVSNGVVIRKDYYAQYRDDNGDLVEERFQETGGDIGLSPKGIRPMTMDEIYDLAETEWLKPEVPAEVFFEVDHLGILSKAGYQAEGCIDDCFKGITIEKITAL
>NZ_CP012851.1|WP_060686363.1|2589214_2589835_-|hypothetical-protein
MELTINIFALNEKHNKVLALTNEEIIISDKKHKTAESVLKSLEKKGMLETLSRIPLSQVVRLEYREEENALEIFFQNAEGKEKSKSVVMGSTEDRAYVIQQLKDNRNFVTTQRAEKKWLPLALNVFWMAFVGGMIWLGLTTNAALAHGEEITYSGRNRGMKKLMTMAFEFLGVEGVWAVGIGVIAYLIWSAYQRFQNPQTIYSIHE
>NZ_CP012851.1|WP_060686372.1|2599729_2601769_+|S9-family-peptidase
MFKRGLLLFSCLLMAWSVTAQKVLTPELLWEMGRVNGGEISPDQTTLLFGVVNYELSENSGKNTLFLKDLKSGEDRELKLPSSASSAVWTPDGQMIGFLMGGQVYEIRPDGSGLRKVTEVESGVSSFTYAASGDKLAFSTSVKLKPTTADLYPDYTKANAVVIDDLMYRHWAAWSDEFFNHVFVADYKEGSISNAKDIMSKEAFDCPTMPFGGGDDYTFSPDGSKLVYVCKKKEGKEYAVSTNTDLYVYDIAASTTQNFTEGMMGYDTHPTFSNDGTKLAWLSMARDGYESDKNDIVVYDFTAQTKTNITKDWDNTVDGFIWGEKDRNIYFVAGKEATYQLWDYKLGKKVADTKVADIRMITEGVHNYGSVAQLDSKTLIGSRMSMSSASELFKVDIKKGTETALTKVNQPIYDSIEMGKVEKRMVPTSDGKEELVWVIYPPNFDPNKKYPALLYCQGGPQSAVSQFFSFRWNFQLMAANGYIVVAPNRRGLPSFGTKWNEDISGDWGGQPMRDYLAAIDAVAAEPYVDNNALGCIGASYGGYSTYMLAGIHEGRFSAFVSHCGLFDMRSWYGTTEELFFANWDLGGAYWEKDAPKAYTEFNPSSYVQNWDTPMMVIHGGKDFRVPEGQGMQAFQAAKLQGIPSRFLYFPEEGHWVLSPQNGMIWHTEFFRWLDEWLKK
>NZ_CP012851.1|WP_060686373.1|2602195_2602378_-|hypothetical-protein
MLEKKAFSAGDFNELEGANPGFTEAGCWILSKPNYSKVDSGSHFKGGVFSFLILMLLIFQ
>NZ_CP012851.1|WP_060686374.1|2602663_2603881_+|6-phosphofructokinase
MKDAIAILCGGGPAPGINTVISSVAKVFLNKGYRVIGLHEGYKGLFSNETKIDEIDYEFADDIYTRGGSALRMSRFKPDLSKLNIPFFKENNIKLLVTIGGDDTASTANRISKYLEENNVSVQNIHVPKTIDNDLPLPEGIPTFGYNSAKNEGVAIANTVLEDARTSQNWFILSAMGREAGHLTIGIGSACHYPMIIIPEMFDKVPVTFENIVRLNISSILKRHILGLKYGASIISEGVFHFMNAEEINNSGIDFPKDDHGHPELHAISKSHVFASLVQKRVKELNLPNKMRPVELGFEVRCAKPIGYDLTYCTLLGFGVYQLFSNGDSRCMVSVDHNGEVKPLFLKDVEDENGRVKARLVNLHAANTQAVMNHGMHYISEEDYEAAKAYVENPEYYDFNQILNR
>NZ_CP012851.1|WP_084792738.1|2604233_2604803_+|N-acetyltransferase
MPMKTIEELPLLKGPKIHLKKPSHQDIPRICELLNEKEVSAYTLFIPHPYQEKDAIFWLNMGHQGLTNQNQFIFGIYKNDNGEFIGGIDLRLERRHKKGELGYWLGKPFWNLGLMTETLELIISWAMEDLKVNKVIALHDINNPASGRVMEKAGMQKEATLFDHYYINGKFISLNQYYIHQHLYNKQQK
>NZ_CP012851.1|WP_060686376.1|2605059_2606676_-|SulP-family-inorganic-anion-transporter
MKNSQSLSLSKSWPGDLLAGLVVFLVALPLCLGIALASGAPMFSGIIAGVVGGLIVAGISNSALGVSGPAAGLVVIVAGAIVDLGFEVFLLAVMISGLIQVAMGYLRAGIVAAFFPTSVIKGMLAGIGIIIILKQIQHALGYDRSFEGELAFMQSSGGNTFYEIVYAFLYFSPGAVMISVCSIILLIGWESKWIKSKQWLKLIPAPLLVVMLGVGLNEIFLHYFPLWAISNDYGNIHLVNLPEVVSFSELKGLLVLPDFGGIAQKEVYVVAVTLAIVGSLESLLSLEATDKMDPYKRVSSKNRELIAQGWGNFCSGLIGGLPITQVIVRSSTNIVSGGKTKLAAIFHGLFMLLFVLLIPAFLNKIPLASLSAILIMVGYKLAKPSVFKSIFQKGRRQFVPFMLTVLGLVFTDMLMGIAIGMSLALFYILLNNYHTPAFLSHVKNLDGGQITIRLAQEVSFLNRASIALMLEDIPEDCALLVDGSDCHFIDEDVLEEIENFAHHAAEHQIQFRVKGLPQLNIPAKWRIDGALPEPAMPV
>NZ_CP012851.1|WP_060686377.1|2607637_2608495_+|alpha/beta-hydrolase
MTDFKTRTYKALGFLTFLYLTVSGIFFFQQEKLMFHPNLLEKNHRFETEVPHYEHYFKMADGTKLHGVYLEAENPKGLVYYYHGNTGDISTYLPSCEFYVASGFDVFLMDYRGFGKSDGKISSEQQFLSDALEVYKMVGTDYTSEEKIIIGYSIGTAPAAYVASKVNSKEVILLAPFTSMHYLREHLYPWLPSIAVNYPLDIQQFLKEAPMPVTIFHGLEDNIIPFDCALQLRKDFKEEDQLFPIPGQDHMKFENQKQYRKQVKKILHRAPQAKKSPLFINPATT
>NZ_CP012851.1|WP_060686378.1|2608829_2609063_-|hypothetical-protein
MALIFLQVWLAEGLRITFNSRSLQGYYHHVRRMLHKWLNRRGGRPAWNWERYNRLITEWRPLLKPKIYHSFQKAKPI
>NZ_CP012851.1|WP_060686379.1|2609053_2610490_-|hypothetical-protein
MSAQEYESIIKGKDEEINSLNEKVDSLQQQLDAVLKLLKTGKSEKRKKSPKDSDIEKPPRKSPKAGSIPPVRKPISDHLEREVEHYKLEIPGAHFLGTEVSEYRKIYPERMVVRQIIRYKYKLPNGDIVIADFPPDIVLPKSGADASLIAYLLIGKFDDHLPWDRQIKILARETGESLAPSTVINWFNNVSRLMLPLFEEAVKMALEAGYLQMDESPIQVLDGEKPGSSHRGYMWVRHVPESGLVIFDYAKGRGKQIPKDLLKKLPDFLQTDGYAAYDQFGQIPDINLLACWAHVRRKFDAALKNHRKKAQIALDLIGRLYALETKAKEEQFSPEQILKMRKSDSIKILEELKSWALNEQKDALPRSLIGKAINYMLNLWDRLITFTQDPQLHPDNNLIENLIRPLALGKKNFLFAGSHAAAQNIAMYYSFFGTCKANGINPSKWLEDVLRRINNHSISKIRELLPLNENLAANPQWL
>NZ_CP012851.1|WP_060686380.1|2610548_2610893_-|IS66-family-insertion-sequence-hypothetical-protein
MLSVGPNDKLNFYAEAVDMRKGFDGLSGLVENELERDPTNGEIFIFINKARNKIKLLQWEAGGFAIYYKRLEKGTFEIPSQKAGDKSIPIPKHTLEMMLCGISLEQRIQRKRYA
>NZ_CP012851.1|WP_060686381.1|2613131_2614862_-|M1-family-peptidase
MPFFYDQHFPSEHHRGDVSDENYFSENSNSRKVILILGNRLESIPLIQSFMIYKFLRTGVLMALLTIASKSIAQQGIDVHHYDFHMMVNSLNDSLNATAQIHFLATEDLDQCTLELVSADENGGMEVLSVSRMGQSVKFEQLKRQLVVDLSLQQGDTASIKVAYRGVPKDGLIIGQNRYGKRTIFGDNWPNRAHHYLPVVDHPSDKATVNWHILAPEHYEVLANGILKEVRPFGGMYKEWFFEEKRDIPTKVMVFGAAQLEAWPLEGALPMKGYAYPEDVEDMKQALSVTQDVLNFFGEYIAPYPFESLWQSQSTTRYGGMENAACIFYDERAADNPKQMERLIAHEIAHQWWGNTVTEVRWNDLWLSEGFATYFTAMYLEHQYGTPALIAFMKEGKDKVFNYKKQFPSKVVVPEVVEDPNKMLNKYSYYKGAWVLHMLRQEIGDLAFRDGIQQYYQTFAGGNANTEDFVATMESVSGRSLKSFFYPWLMEAGLPRLSYKVTYDKETKESIVTVRQEQQNLTSFPLELMAITFEGDKIYFSEKLSEKEQVFRLAVGEEPNAIKLDPNGHLLFELAE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

915138 : 924697

Mycobacterium_phage(14.29%)

integrase

attL 918164:918179|attR 926734:926749

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060685224.1\|915138_915894_+	alpha/beta hydrolase	G1BRG0	Mycobacterium_phage	9.4e-09	28.6
WP_060685225.1\|915895_916609_+	SAM-dependent methyltransferase	NA	NA	NA	NA
WP_060685226.1\|916758_918015_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.1e-107	49.4
918164:918179	attL	NA	NA	NA	NA
WP_084792686.1\|918478_918847_-	ribosomal subunit interface protein	NA	NA	NA	NA
WP_060685227.1\|918870_919773_-\|integrase	integrase	A0A0K2CP59	Brevibacillus_phage	2.2e-33	32.8
WP_053406152.1\|919919_920114_-	30S ribosomal protein S21	NA	NA	NA	NA
WP_060685228.1\|920359_921691_+	UDP-glucose/GDP-mannose dehydrogenase family protein	A0A127AXI2	Bacillus_phage	7.8e-83	39.2
WP_053406150.1\|921696_922683_+	NAD-dependent epimerase/dehydratase family protein	A0A2K9KZK0	Tupanvirus	7.3e-70	44.6
WP_060685229.1\|922690_923740_+	dTDP-glucose 4,6-dehydratase	A0A1D7XFE8	Escherichia_phage	2.5e-84	50.5
WP_060685230.1\|923791_924697_+	glucose-1-phosphate thymidylyltransferase	I7I009	Enterobacteria_phage	9.3e-96	58.7
926734:926749	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1178677 : 1266128

uncultured_Mediterranean_phage(20.0%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_053404105.1\|1178677_1179703_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_053404105.1\|1180078_1181104_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_060685406.1\|1181389_1181716_+	hypothetical protein	NA	NA	NA	NA
WP_060687353.1\|1182076_1183387_+	30S ribosomal protein S12 methylthiotransferase RimO	NA	NA	NA	NA
WP_071932165.1\|1183846_1184485_+	hypothetical protein	NA	NA	NA	NA
WP_060685408.1\|1184665_1185358_+	hypothetical protein	NA	NA	NA	NA
WP_060685409.1\|1185807_1188690_-	ATP-dependent helicase	A0A0P0CJA9	Ostreococcus_lucimarinus_virus	2.1e-45	31.1
WP_060685410.1\|1189126_1190692_+	bacillithiol biosynthesis cysteine-adding enzyme BshC	NA	NA	NA	NA
WP_060685411.1\|1190720_1192199_-	carbon starvation protein A	NA	NA	NA	NA
WP_060685412.1\|1192400_1193219_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_060685413.1\|1193415_1195908_+	hypothetical protein	NA	NA	NA	NA
WP_060685414.1\|1197115_1199008_+	ABC transporter ATP-binding protein	A0A2K9L3Z8	Tupanvirus	1.3e-54	30.8
WP_060685415.1\|1200687_1203894_+	SusC/RagA family TonB-linked outer membrane protein	NA	NA	NA	NA
WP_060685416.1\|1203955_1205389_+	SusD/RagB family nutrient-binding outer membrane lipoprotein	NA	NA	NA	NA
WP_060685417.1\|1205410_1206727_+	hypothetical protein	NA	NA	NA	NA
WP_060685418.1\|1208062_1211101_+	TonB-dependent receptor	NA	NA	NA	NA
WP_060685419.1\|1211113_1212538_+	RagB/SusD family nutrient uptake outer membrane protein	NA	NA	NA	NA
WP_060685420.1\|1212560_1213415_+	hypothetical protein	NA	NA	NA	NA
WP_084792695.1\|1213498_1216903_+	hypothetical protein	NA	NA	NA	NA
WP_063790775.1\|1217540_1220528_+	TonB-dependent receptor	NA	NA	NA	NA
WP_060685423.1\|1220539_1222180_+	RagB/SusD family nutrient uptake outer membrane protein	NA	NA	NA	NA
WP_060685424.1\|1222230_1223742_+	hypothetical protein	NA	NA	NA	NA
WP_060685425.1\|1224092_1224278_+	hypothetical protein	NA	NA	NA	NA
WP_060685426.1\|1224877_1227877_+	TonB-dependent receptor	NA	NA	NA	NA
WP_060685427.1\|1227897_1229568_+	RagB/SusD family nutrient uptake outer membrane protein	NA	NA	NA	NA
WP_060685428.1\|1229627_1230713_+	hypothetical protein	NA	NA	NA	NA
WP_060685429.1\|1231170_1231725_+	hypothetical protein	NA	NA	NA	NA
WP_060685430.1\|1232059_1233469_-	ATP-dependent helicase	A0A1B1IS59	uncultured_Mediterranean_phage	2.0e-52	34.3
WP_060685431.1\|1233570_1234911_+	dihydroorotase	NA	NA	NA	NA
WP_060684661.1\|1237081_1238479_+	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	3.8e-32	31.8
WP_084792696.1\|1238690_1242134_-	hypothetical protein	NA	NA	NA	NA
WP_060685433.1\|1242540_1243815_+	ATP-dependent helicase	A0A1B1IS59	uncultured_Mediterranean_phage	7.3e-54	32.8
WP_053405906.1\|1243894_1244281_-	hypothetical protein	NA	NA	NA	NA
WP_053405905.1\|1244294_1245701_-	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	E4ZFI6	Streptococcus_phage	7.7e-57	30.3
WP_060685434.1\|1245846_1246635_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_060685435.1\|1246645_1247014_+	YccF domain-containing protein	NA	NA	NA	NA
WP_060685436.1\|1247072_1247708_+	acetyltransferase	NA	NA	NA	NA
WP_060685295.1\|1250320_1251385_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_060685439.1\|1251678_1252647_-\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	4.8e-42	37.9
WP_060685440.1\|1253048_1255034_-	hypothetical protein	NA	NA	NA	NA
WP_060685441.1\|1255248_1257732_+	endopeptidase La	A0A0R6PGP8	Moraxella_phage	1.7e-163	41.6
WP_060685442.1\|1257971_1258985_+	hypothetical protein	NA	NA	NA	NA
WP_060685443.1\|1259032_1260418_+\|protease	ATP-dependent protease ATPase subunit HslU	A0A2H5BJT2	Erwinia_phage	9.0e-42	28.8
WP_060685444.1\|1260526_1261252_+	hypothetical protein	NA	NA	NA	NA
WP_060685445.1\|1261228_1261762_-	hypothetical protein	NA	NA	NA	NA
WP_060685446.1\|1261918_1262557_+	ATP-binding protein	NA	NA	NA	NA
WP_060685447.1\|1262558_1263017_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_060685448.1\|1263084_1263537_-	CBS domain-containing protein	NA	NA	NA	NA
WP_060685449.1\|1263898_1265239_+	hypothetical protein	NA	NA	NA	NA
WP_053403906.1\|1265459_1266128_+\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	1.0e-43	50.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP012865

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012865_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012865_1

23225-23324

Orphan

Consensus_repeat	Method
TAAAGGGAGTAATTTGCCTATATTAAGGGAGAAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012865_1

>merge|NZ_CP012865|1|23225-23324|CRISPRCasFinder
TAAAGGGAGTAATTTGCCTATATTAAGGGAGAAATGTACTCCATTAAGGGAGTAATTTACGGTTTTAAAGGGAGTAATTTGCCTATATTAAGGGAGTAAA

>NZ_CP012865|1|1|23225-23324|CRISPRCasFinder
TAAAGGGAGTAATTTGCCTATATTAAGGGAGAAAT	GTACTCCATTAAGGGAGTAATTTACGGTTT
TAAAGGGAGTAATTTGCCTATATTAAGGGAGTAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012865.1\|WP_060690441.1\|11661_12186_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012865.1\|WP_060690452.1\|25216_26050_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214678
NZ_CP012865.1\|WP_060690455.1\|29886_31809_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012865.1\|WP_060686527.1\|36787_37915_+\|IS4/IS5-family-transposase	unknown	unknown	gnl\|CDD\|376573
NZ_CP012865.1\|WP_060690444.1\|12880_14011_-\|IS630-family-transposase	unknown	unknown	gnl\|CDD\|315923
NZ_CP012865.1\|WP_060690446.1\|15452_16496_-\|linear-amide-C-N-hydrolase	unknown	unknown	gnl\|CDD\|238303
NZ_CP012865.1\|WP_060690442.1\|12271_12463_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012865.1\|WP_060690445.1\|14040_15294_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|365903
NZ_CP012865.1\|WP_060690450.1\|22026_22323_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012865.1\|WP_060690459.1\|38389_38857_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239530
NZ_CP012865.1\|WP_060690453.1\|26042_27122_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379293
NZ_CP012865.1\|WP_060690458.1\|35247_36456_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
NZ_CP012865.1\|WP_060690457.1\|33214_34615_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|365903
NZ_CP012865.1\|WP_060690448.1\|18815_19874_-\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|223597
NZ_CP012865.1\|WP_060690443.1\|12491_12824_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367760
NZ_CP012865.1\|WP_060690447.1\|17111_18113_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP012865.1\|WP_060690456.1\|31811_32858_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012865.1\|WP_060690451.1\|23533_24898_+\|RepB-family-plasmid-replication-initiator-protein	unknown	unknown	gnl\|CDD\|376444
NZ_CP012865.1\|WP_060690454.1\|27541_28381_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012865.1\|WP_060690449.1\|19873_21532_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|238625

Protein	Function_ID	Function_description	E-value
NZ_CP012865.1\|WP_060690458.1\|35247_36456_+\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	7.22264e-92
NZ_CP012865.1\|WP_060686527.1\|36787_37915_+\|IS4/IS5-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.16134e-12
NZ_CP012865.1\|WP_060690444.1\|12880_14011_-\|IS630-family-transposase	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.08415e-22
NZ_CP012865.1\|WP_060690445.1\|14040_15294_-\|hypothetical-protein	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	8.53582e-20
NZ_CP012865.1\|WP_060690452.1\|25216_26050_-\|hypothetical-protein	gnl\|CDD\|214678	smart00470, ParB, ParB-like nuclease domain. Plasmid RK2 ParB preferentially cleaves single-stranded DNA. ParB also nicks supercoiled plasmid DNA preferably at sites with potential single-stranded character, like AT-rich regions and sequences that can form cruciform structures. ParB also exhibits 5-->3 exonuclease activity.	4.50857e-08
NZ_CP012865.1\|WP_060690446.1\|15452_16496_-\|linear-amide-C-N-hydrolase	gnl\|CDD\|238303	cd00542, Ntn_PVA, Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal nucleophilic cysteine, as do other members of the Ntn hydrolase family to which PVA belongs. This nucleophilic cysteine is exposed by post-translational prossessing of the PVA precursor. PVA forms a homotetramer.	1.46281e-73
NZ_CP012865.1\|WP_060690457.1\|33214_34615_+\|hypothetical-protein	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	5.85137e-26
NZ_CP012865.1\|WP_060690459.1\|38389_38857_+\|hypothetical-protein	gnl\|CDD\|239530	cd03446, MaoC_like, MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.	2.45898e-37
NZ_CP012865.1\|WP_060690453.1\|26042_27122_-\|hypothetical-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	1.03844e-34
NZ_CP012865.1\|WP_060690448.1\|18815_19874_-\|GTP-binding-protein	gnl\|CDD\|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	7.89776e-75
NZ_CP012865.1\|WP_060690443.1\|12491_12824_-\|hypothetical-protein	gnl\|CDD\|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	0.000804993
NZ_CP012865.1\|WP_060690447.1\|17111_18113_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	3.65846e-23
NZ_CP012865.1\|WP_060690451.1\|23533_24898_+\|RepB-family-plasmid-replication-initiator-protein	gnl\|CDD\|376444	pfam01051, Rep_3, Initiator Replication protein. This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.	2.17671e-35
NZ_CP012865.1\|WP_060690449.1\|19873_21532_-\|amidohydrolase	gnl\|CDD\|238625	cd01300, YtcJ_like, YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.	5.46346e-105

>NZ_CP012865.1|WP_060690450.1|22026_22323_-|hypothetical-protein
MDPISKTISDAHALLRSHVWSLEEFIVKMKNEEIPAAILIADPNPISLKMEAINQLTQTPPYSVVFNQKWHMISSKGKHDAPGDSISTYLTINKQQVA
>NZ_CP012865.1|WP_060690449.1|19873_21532_-|amidohydrolase
MKKQKVTVFTAKKIRTMDPGRPEAEAVAVLDGKILSVGSVEFMKPWLDQYEVTIDNTFEDKIMVPGFIEPHSHGWMSAGFMGLDYIGPLAWPGLKGINPGHPAFEDVIAYLKELDQQKKDPNAPIIAWGFDPANQGGGLDRDTLDKITKTRPIFVIGFAPHFAYLNSAALELAKVPVDSKSSHIEHYPDGRLNGVFTEAEGVSIGIAPVLPIIAQLGGAKGVKFMSDICNRAGITLIADLMFGIINYDAELADHQEAVKDSDFPVRIVLTPHGPSIVAKHGDNSAEFVKNLSQYETDKLYFKGVKFLSDGSFPLMGSQVNFPGYLDGTNGIAGDSSYEGMLPFWKAGVQIHCHANGDWAVDRTLDMLAQLQEAHPRFDHRFTIEHYAMSNPMQARRLKALGGLASVNNYFTHFRSLLHSEHAYGPDRAQTEARLGTLEREGVIFALHSDYPQVVVPMDPLTAVYTAVNRIAEDGKTIVAPHEKIGVERALRAVTIDAAYILGIEDKLGSIEQGKMADFTILDEDPQEVKPEEIKEISVWGTVLGGKKFEIKD
>NZ_CP012865.1|WP_060690448.1|18815_19874_-|GTP-binding-protein
MEITNAHKKLASTRDPLQYALDSRQSVMGLVFAAMALNQSPISQEKNLPLTIIGGFLGAGKTTMLNHILSHPGGRKIVVLVNDFGKVNIDAALIESQTDDMINLSNGCACCAVSSDLTQSLKEITERDEQPDAIILECSGIAEPGAIAQTALANKALHLDGIITMIDAETFFERINDPQSNGLFLSQIHSSDMILLNKADLIGQEKLSKIRKRIEAEYPQKVLIETTLGAVSTEVVLGISSKQKHFEKDGRSKTVNHGFQSLSFEFDKPFEEEKLIDFLSGLPEKIIRAKGVLDLDQQGKEMIYQRVSSRWSLVPGNLWPKKQPKSILVFIANKGELNQEVLREKLMSCLKV
>NZ_CP012865.1|WP_060690447.1|17111_18113_+|AraC-family-transcriptional-regulator
MPVTFPKDPNDPIIVEFNEISSADNNQQLAEEIGGSWDGHHLQVKNEYFDLDVRHFFFLEQLTVEICELYLYKNTHFCQRLEKNRDHVCIRIGFSGLIVNLQEEKPFDSNGVYVYNTNQDFNIEFPAGATLRWVGLKFPTEVIPKIFTHEKPYKFKALARETAPWIHYFSLDAELEEHIKAIFEQGRASNGREATPLSRSIDIIGAVKEKLEMDDPTQVHERIHPEDLQKIITIKDQILSNMDQIPKLEEYSSEHGMSVSKMNALFKRVFKLPLLKFYNTQKLEEARRKIQHTNLSLTEIADELGFSHVAHMSRTFKKQYGFPPSALRRISAV
>NZ_CP012865.1|WP_060690446.1|15452_16496_-|linear-amide-C-N-hydrolase
MCTGIRLIANDGSPVFGRTEEFAEEMLHMHLLKAGRGTKFRGATHEGENGMSWEADYGFVAGIPFKMQAPIEGLNEAGLQGGVFFFQPYDKGRYQNHNPEEFDRTISAWQLLTFLLSKAASVADVKRLVNEIRVVNSIPQPRTPGWEFEPIAHWAINDDTGAAVVIEYLDGELNIFDNPLGTITNAPAFPWHQENLKQFTSLPIDQRPPFERQTGEQGASGLDIGSKTNLPGQITSANRFVRASIFTQYAFPFADSTEGVKRVLNILNNFDIPLGYKTYKNVDGDIFPQYTSFTTISDLRNRVLYFRLFGNPTLHKVDLKEVDFSKSEITFVPVNNEFTTVPVNMNV
>NZ_CP012865.1|WP_060690445.1|14040_15294_-|hypothetical-protein
MSNTKSNMHPIAEFKNGFTLEQSKAFRNHRDLNVWLGGGDASVWVNTKPSEAFPSTAYVPNRLPARTLAKDINPEIGQISTETNNFGNISLDDFMAHPDSRAQAFMVIHKGTIVYENYQALQPTDNHIWMSTAKVLPSLIMDLLIDEGKIEESKTVGDYLPDFKGTDWEHIKVIDVMDMTTGLNIEELQNGLWYAPGSIAQRMLSAEFGLTYNEKVEDFTAVLKDAKKVREPGYQYDYSSVATQVLVLIAEAITGERWAQTVDKRVWSKIGMEAPLLVHTTPDGIAMGHGMVSSRLSDFGRFGMLYTPSWNKISDEQIVTADILKRIQTGTRNLDFFMRGSGPLRVSQLNDDTMIGSSRQWDSVWEEGDFFKSGFQQQGLYVSPSRDLVIVHFSVNGPDDSIKHFLRPLVTSIAFKK
>NZ_CP012865.1|WP_060690444.1|12880_14011_-|IS630-family-transposase
MAHSKKGKLSISKEELKALKAISTSRTESSSKVNRSRIIIDYHSGVTVAAITRKYNTNRPLVERTIDKALAFGALAALNDLPRSGRPAEITDDAKAWVLSIACESPTKFGYAAETWTYSALASHIKKECIKAGYECLKNTGKGFLNSVLAKSNIKPHKISYYLEKKDPDFDAKMASVLHVYKEVALVNDNNACNYKQTTVSYDEKPGIQAIKNIAPQLLPVPNKYSSVGRDYEYKRLGTVSLLAAIDLHNGVVTPMVCDRHRSAEFIEFLKKLDNQYPKDWRIRIILDNHSSHISKETKKYLADIPNRFEFVFTPKHGSWLNMIEMFFSKIARSFLRNIRVNSKEELIERIYKGIEEINQEPVVFKWKYKLDELEC
>NZ_CP012865.1|WP_060690443.1|12491_12824_-|hypothetical-protein
MEEINFWSLLEVKVLNATAKEAVEKHTNMHAIAECVESIPGCLYGEDMLSDEDPQLMLTICGWKSKSDYEAWQQSPVRDKQVEAFAGLYTVEAKEHTFNSFHKVLQKLRK
>NZ_CP012865.1|WP_060690442.1|12271_12463_+|hypothetical-protein
MLAPHSSVSLEKTRNRKDPFIFSTLQPNEDLSMNNPGLHSLDAEIINIIFALNTSLQEGPVTF
>NZ_CP012865.1|WP_060690441.1|11661_12186_+|hypothetical-protein
MPVTFPKDSNAPVIVEYNEISSAENNQKLAEEIGGSWDGHHLQVKNEYFDLDVHHFFFLEQLTVEICELYLHKNTYFIQNLEKNRDHICIRVGFSGLIINLSEEKSFQSNGIFVYNTNQDFNVEFPAGATIRWVGLKFPKELISRIFTHEKTLQVSGIGPGACPLGTLTRIIHR
>NZ_CP012865.1|WP_060690451.1|23533_24898_+|RepB-family-plasmid-replication-initiator-protein
MENAYIFMAEVNLEYSIVKSNRLVESRNHFSVVQQRILAVAFSLLQPDQEKFEWIEIPVKSLFTGKIGKSQYNLVKKAVSEMTELTVYVTGDNGYWRKVSLLEASGYDADRTVKVRFIENARDLLMGFSGEYTKYLLGNVWSFDSSYSFNVYELCKQYQKVGKRTVSIIFLRERLGLIKHKPGTRGNSMMLSEEELMKMDTKYPAFKDFEKYVLQAAQRDINTQSDLHIEYEKHKKGRSIVSLTFEIKANPKYQRPKIESLPKGAVREYGHQDEKEVYVDEYIAKQKSVKNKSAYRKKLMNDPEFEDQFQSSQKQKKEAEKAAQQKAGEQELTLQIEEWKAEFNQLYKSVRLPYCQMANENGELISEFRSWYQAHGSVTDKRGILERIDAHEMKSSDWLKFGTFMIERMGTEEEKKYFLKANPQAFLEMKRSQWDAQYGVKITPAKPVFNGFDE
>NZ_CP012865.1|WP_060690452.1|25216_26050_-|hypothetical-protein
MAKRQRSTTFKANEQILKNHQDVQAKNSEQLHYKMLKTTALTTNRFIERYIEPLAPDSYAALRADIENRGVVDPLSVWENEDTYILVDGHHRKKIAEELKIDLLPIIKIEEIDSLEDAFRYMNSKQVGRRNISKLHKDYLIGRDYKLAKERQSNNDGSLVAVFSNKYGISQKSLFNNLDFYTGVELIKKEQPDQYEAILGLSDEKSLFNKSQVIQMAKEGSLEKETPAPKVALSPLEKHQKSAAVLFDRIKKMKDQHQKQQLIQELKNQIEQLEAEL
>NZ_CP012865.1|WP_060690453.1|26042_27122_-|hypothetical-protein
MEFNKQDALNQGLAKWIIKQKKLLNISAISEETGVSRTQLNRVLEGKADFNNGHFNKLFPVLKDWFGLTEEQLIELVQDAAKILAFWNQKGGVGKTTCCNSIAGVLTDQGKKVLVMDCDYQGNSTSLWNIDKQAFPMEIMDALEDTQGELIRDCIVQLHDISEQLYILPSYGKLNNLETSEKLTTKQKLESFKNIVNKIRFEYDYILMDMRPDMYGLFSEAPLGAAEWVFLPVEASLFSFDGLSRSVSYLKERKKDNPLLKIGGAFFNRTKPGKNQMEQIENYALGAEREGIYVFESIIRDSVGIQKAFTYRYDPTVFLNKFNEGEIADFPKTQLEPIKNAKSDFMELTTELLNRIQNG
>NZ_CP012865.1|WP_060690454.1|27541_28381_+|hypothetical-protein
MDNLDELNRYLKKYADQQNLKARSDFEGYSALEMQILLRGCFQERSLIKLGQLDREELEAIPLLQLVKQLLISVQQLGEMKLTPKGNLPVKVVKDLYTTEFFESQVIEHGLVKLSKEEAFYPIHLSRILAEVAGITKKRKGKLSLTKKGGKLLKDDQQLLECIFKSYCLDFNWAYGDGHEVEETGQLGFAFSCFLMQKYGDQYRPSEFYGERYFQAFPSLLTSRKDACLFVYDYRTFERMGEYFGLVTLKGEFKVIRNNYEVKPTPLFRKFIKITPPKG
>NZ_CP012865.1|WP_060690455.1|29886_31809_+|hypothetical-protein
MKRIWFVQFILVLASCQEPIDPVITSVQNTKQLLQSHIWTLEDFDIRTTNEEIPAPILFGATENHALWPGVSSDENQDDPMSVIFTPDRKVIASQGLHDALGDSISSYFVINDHLIRLSSQAVSINYEYLYSAQEKEFQFYTDAEGVMKLVHETNQKFISAVTEQTPQKVGDIIAALVYNNETIQQLINKLVVQALAGELSFLNEFDPEQVAQELAGKIIQLLQQIDWEQELTDILKPEFEKLNQIDPEEATQVVAQALAQYLQQALSEENLYKGILPLVLELKQHPKEGAATIAKLVNEIFLDFFDQEHISPIISEAWLKFSALDPQQVNQLAVELTRLLEAAFINEAELTQLCLPFIQKIEDTPLFELGELAATTTDALRGLIDQLNQQFPDLNLDPDYETMEGIIKAAFITAKPIIGLSGVETVAQEVAQLILTQVLTTDFLQQSIMVALESLQKLDPQNVGATLGQWIAQLALEVSPVLLSEVQQVVSPILAQLDAEGIASVIAASLSELVSEHLNPAQLEPLVFPLLEAISNVNAEALARLFAQSILELDAIKDLITEEKLVAILLPVLESVAAINPEELAQSIIDAVVATGIFDSVLTEERASALIAILWYNSLWEQVTVANNFESVTIKLAHP
>NZ_CP012865.1|WP_060690456.1|31811_32858_+|hypothetical-protein
MKKSLLFVLFLQIVAFSAIGQVSNLSIDDDYQHYRDSLKTTEYPWHLPIMGGKVRKMGFDIPYPNGFMFSYGHSSQNIFINNLEVGFHPDQMMGVDELARFQSIQSNVNAFVLKYDFWLFPFLNFFGLAGHINSTTNVHLALPFDLKFQTNNQGNTLGWGMVAAGGIGPLVVSGNLVNTWTWVPSLDRPSNTMVVDGRIGYMMRFPHKPQRNLVFLVGVEYMRLNPQSEGNVNLEKLLDISPQMKQDAGQQLDQWYDGLSNVEQGLVEGVYNGLSGWLNSSDPITMDYRFRKGLHHPMSMTAGVNFQYSHRWSYNLMNTFLGSRKQVVFSLNYRFGIKGNNVMSGFTF
>NZ_CP012865.1|WP_060690457.1|33214_34615_+|hypothetical-protein
MKLKLSLIALSVVAIQSCQQAQNPQQEEASTSVSQEVSNGYETLPNASTLTLAEHKQLLEEGYPIERVRRAKALFSARHFTVDAMDDLATAEDDALYYFNFMDEFMPSAKVQASPNKFDLARDLNPALAEVSYKDLEGKARPTFQEYINDPKSRLQAAMIIKKGKVVFETYPGMRPEDKHVWMSVSKPLAGVAVLDLIDKGQVDPNAPITQYVPRLQGSAWDGVPVKAVLTMTTGLNAADISGNMFKAGTMEQRYYQASFGDLYNGKKEDWIQVIRESKKIAEPYTLYQYASMNTQVLSIAVENITGKKFVDYLYERFFEYAGTGEFVANLFPDGSIHAATAMNSTLEDLARYGLLFTPTFEQITGKEVVSPRLIDYMFENKVPMEIFKESAVGKMGQMIMGEQVICGSGSQFDFLWEDGAFAKLGHNGQGIYVDPAREVVGVYFSASTELNYPVAYMRAAATALD
>NZ_CP012865.1|WP_060690458.1|35247_36456_+|CoA-transferase
MSIILEGIKVIEVASMAAAPSATVMLADLGAEVIKIEPPQGDLWRYGNKVAGMPASDIPYTTFIQNRSKKSVALDLKKPEAQDILNKLVETADVFLTNSPRAVQKHLGHTYEDIKAINPKIVYAWINGFGVAGPDKDAPGFDMTAWYARTGMMEELRPKDGSPVPLPVGVGDLGTASTLFGAVMTGLFHRQRTGEGVKVSTSLMNNGIWANSSMMQAALVGAPAMQKFHRTEWPNPVSGGVFKTKDDRYIIIVELNPKNIGNLRDAFGADHLKGDERFATPQARGVNHQALFDEMQKIVGAYDLATVRERLKSFGVNFSVVQTTEECTRDEHMIANGCFPEVAGTEGIRTVDSPIQVEGIAKVQPQNPPKVGGNTVEELSALGFSQDTIEGLAAAGAIGISK
>NZ_CP012865.1|WP_060686527.1|36787_37915_+|IS4/IS5-family-transposase
MFDSLHDKLTQQFPKWGKACWKNVLALSLGIIQKGTVCLNKVKDCIGSILENQSTSAFGHYKRLTRIFTKYSDTHLWSDLLQLSAMHMHKGGDFLMVDGTSWKLGDRTFHFMTLAILYNGIAVPIYFMNLEKKGISNQEERIQLLEEASKLFNLEGKILLADREYAGQKFIKYLEDNGFKYVLRVKECNFKTQWNEKSMTKAQMISKVTNSKVKGKTMSAKMKFEAGDNCRMVIKKSEDAEKEPVIFLLTNLSKNAYKVAEDYRKRWQIETCFRHLKTNGFDLEKMNVQGADRCRLMMAIVVFAYSVSIAHGLKKYKSVSLKTYANGKRYRSISVFRKGVECIAEAGYRIENWGEYILNHFLSHDQKISPKSINV
>NZ_CP012865.1|WP_060690459.1|38389_38857_+|hypothetical-protein
MSDNAKFFEDYNIGDFEIEKTDSRTITEADIVFHSMHSGDWMPHHNDEEWCKTQPFKHRIAHGNLSFCIGTGLIVMSSDRNPNCMSYGYEKLRFPHPVYAGDTLTASVKVLDKKDHPKHKTHGLMTHAETVTNQRGEVVCYAEHIFFTVRRTPKA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

4. NZ_CP012855

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012855_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012855_1

24866-24958

Orphan

Consensus_repeat	Method
TTGCGTACTTTTGTCGGTAGTTCGCGTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012855_1

>merge|NZ_CP012855|1|24866-24958|CRISPRCasFinder
TTGCGTACTTTTGTCGGTAGTTCGCGTACAATTGGTGGTTTTACTGCGTACTTCTTTCGGTAGTTTGCGTACTTTTGTCGGTAGTTCGCGTAC

>NZ_CP012855|1|1|24866-24958|CRISPRCasFinder
TTGCGTACTTTTGTCGGTAGTTCGCGTAC	AATTGGTGGTTTTACTGCGTACTTCTTTCGGTAGT
TTGCGTACTTTTGTCGGTAGTTCGCGTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012855.1\|WP_063791121.1\|28504_28987_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|273179
NZ_CP012855.1\|WP_060688784.1\|26450_26684_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012855.1\|WP_060688775.1\|16499_18614_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012855.1\|WP_060688788.1\|29589_29769_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012855.1\|WP_060688787.1\|29066_29537_+\|DUF4494-domain-containing-protein	unknown	unknown	gnl\|CDD\|379718
NZ_CP012855.1\|WP_060688789.1\|29916_30360_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012855.1\|WP_060688783.1\|25977_26340_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|269840
NZ_CP012855.1\|WP_060688774.1\|15612_16458_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|132933
NZ_CP012855.1\|WP_060688777.1\|19460_20087_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012855.1\|WP_060688786.1\|28239_28512_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012855.1\|WP_060688773.1\|15223_15613_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368550
NZ_CP012855.1\|WP_060688781.1\|23178_24633_-\|replication-initiation-protein	unknown	unknown	gnl\|CDD\|376444
NZ_CP012855.1\|WP_060688780.1\|21689_22760_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379293
NZ_CP012855.1\|WP_060688776.1\|18613_19459_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012855.1\|WP_060688778.1\|20127_20634_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012855.1\|WP_060688790.1\|30706_31498_-\|nucleotidyltransferase	unknown	unknown	gnl\|CDD\|375587
NZ_CP012855.1\|WP_060688785.1\|27339_28215_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012855.1\|WP_060688779.1\|20812_21685_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319261
NZ_CP012855.1\|WP_060688772.1\|14251_15217_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012855.1\|WP_060688782.1\|25082_25763_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|311152

Protein	Function_ID	Function_description	E-value
NZ_CP012855.1\|WP_063791121.1\|28504_28987_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|273179	TIGR00621, Single-stranded_DNA-binding_protein, single stranded DNA-binding protein (ssb). All proteins in this family for which functions are known are single-stranded DNA binding proteins that function in many processes including transcription, repair, replication and recombination. Members encoded between genes for ribosomal proteins S6 and S18 should be annotated as primosomal protein N (PriB). Forms in gamma-protoeobacteria are much shorter and poorly recognized by this model. Additional members of this family include phage proteins. Eukaryotic members are organellar proteins. [DNA metabolism, DNA replication, recombination, and repair].	2.21636e-45
NZ_CP012855.1\|WP_060688773.1\|15223_15613_-\|hypothetical-protein	gnl\|CDD\|368550	pfam05667, DUF812, Protein of unknown function (DUF812). This family consists of several eukaryotic proteins of unknown function.	0.00128907
NZ_CP012855.1\|WP_060688774.1\|15612_16458_-\|hypothetical-protein	gnl\|CDD\|132933	cd07022, S49_Sppa_36K_type, Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad. Signal peptide peptidase A (SppA; Peptidase S49; Protease IV) 36K type: SppA is found in all three domains of life and is involved in the cleavage of signal peptides after their removal from the precursor proteins by signal peptidases. Members in this subfamily are all bacterial and include sohB peptidase and protein C. These are sometimes referred to as 36K type since they contain only one domain, unlike E. coli SppA that also contains an amino-terminal domain. Site-directed mutagenesis and sequence analysis have shown these SppAs to be serine proteases. The predicted active site serine for members in this family occurs in a transmembrane domain. Mutagenesis studies also suggest that the catalytic center comprises a Ser-Lys dyad and not the usual Ser-His-Asp catalytic triad found in the majority of serine proteases.	4.12187e-37
NZ_CP012855.1\|WP_060688783.1\|25977_26340_-\|hypothetical-protein	gnl\|CDD\|269840	cd14692, bZIP_ATF4, Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain. ATF-4 was also isolated and characterized as the cAMP-response element binding protein 2 (CREB2). It is a Basic leucine zipper (bZIP) transcription factor that has been reported to act as both an activator or repressor. It is a critical component in both the unfolded protein response (UPR) and amino acid response (AAR) pathways. Under certain stress conditions, ATF-4 transcription is increased; accumulation of ATF-4 induces the expression of genes involved in amino acid metabolism and transport, mitochondrial function, redox chemistry, and others that ensure protein synthesis and recovery from stress. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.	0.0081821
NZ_CP012855.1\|WP_060688780.1\|21689_22760_-\|hypothetical-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	2.9729e-35
NZ_CP012855.1\|WP_060688781.1\|23178_24633_-\|replication-initiation-protein	gnl\|CDD\|376444	pfam01051, Rep_3, Initiator Replication protein. This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.	2.13976e-31
NZ_CP012855.1\|WP_060688787.1\|29066_29537_+\|DUF4494-domain-containing-protein	gnl\|CDD\|379718	pfam14902, DUF4494, Domain of unknown function (DUF4494). This family of proteins is found in bacteria. Proteins in this family are typically between 154 and 172 amino acids in length. There are two conserved sequence motifs: VDA and EAE. There is a single completely conserved residue E that may be functionally important.	1.32381e-60
NZ_CP012855.1\|WP_060688779.1\|20812_21685_-\|hypothetical-protein	gnl\|CDD\|319261	cd16404, pNOB8_ParB_N_like, pNOB8 ParB-like N-terminal domain, plasmid partitioning system protein domain. archaeal pNOB8 ParB acts in a plasmid partitioning system made up of 3 parts: AspA, ParA motor protein, and ParB, which links ParA to the protein-DNA superhelix. As demonstrated in Sulfolobus, AspA spreads along DNA, which allows ParB binding, and links to the Walker-motif containing ParA motor protein. The Sulfolobus ParB C-terminal domain resembles eukaryotic segregation protein CenpA, and other histones. This family is related to the N-terminal domain of ParB (Spo0J in Bacillus subtilis), a DNA-binding component of the prokaryotic parABS partitioning system and related proteins.	2.36768e-10
NZ_CP012855.1\|WP_060688790.1\|30706_31498_-\|nucleotidyltransferase	gnl\|CDD\|375587	pfam18144, SMODS, Second Messenger Oligonucleotide or Dinucleotide Synthetase domain. Nucleotide synthetase enzyme of the DNA polymerase beta superfamily. Experimental studies have demonstrated cGAMP synthetase activity in the Vibrio cholerae DncV protein, a member of the SMODS family. The diversity inherent to the SMODS family suggests members of the family could generate a range of nucleotides, cyclic and/or linear. The nucleotide second messengers generated by the SMODS domains are predicted to activate effectors in a class of conflict systems reliant on the production and sensing of the nucleotide second messengers.	8.21253e-43
NZ_CP012855.1\|WP_060688782.1\|25082_25763_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|311152	pfam07022, Phage_CI_repr, Bacteriophage CI repressor helix-turn-helix domain. This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic.	7.9967e-10

>NZ_CP012855.1|WP_060688781.1|23178_24633_-|replication-initiation-protein
MIDNQIPDLELSIVKSNKLVETRNHLSVLQQRILAVAFSRLKPQQERFDWMEIPMQALFTSRVGLRQYELVSNALKEMTTLTMDVSAKNGKYWRSVPLLEAEGDEDRRVVRVRFIENARDLLIDIDTAEGYTSYLLGHVWSFKSSHTFRIYELCKQYLSLGKRKVSVVFLRERLGLIIHPVGKKNRNNEILEDADLKKLKTRYPRFNDFETKVLKVAQEEINTTSDILIDYEKVRSGRAIEYIIFKIERNPDYVAENKQVKLKLPKVKPAAKSEQRTLDIPFEEVEKTEKTEKEIYAEQYIANQKGVKNPEAYKMKLMGDDAFHRQFVQDTETQKVQEAEAERVSQEKQRAQELEELEEKWAQEYGENYKKVRVPYCQMVNQKPELIDSFREWYMENGSSTGKREVLERIANRKLESGDWLKFGTYMIATIGTTEEKTWYLSADPRKYIEARREAWRAEQQNTPVKEPIENQAQSPLFTGFEDL
>NZ_CP012855.1|WP_060688780.1|21689_22760_-|hypothetical-protein
MKDLNIALSKWIAEKKKILNLSEINEQTEVSRTTLSQVINHQQVLSPKLTQQLLPYFEANYGLTEEKLLDLINPPAKVIAFWNQKGGVGKTTTSISIASAFANEGKKVLLIDADYQNNALAAYGISRYDLEEDGESVPSLMDVLVDNSKFEEALVQPMEALDNYHLLPNYGELTSLLKEGIGLSPLQKSKCFDTLIKSINRDYDIIIIDMRPDLDTIFSYAPLLGAEHVYLPLDASRFSIQGLVDSYNYISQIHKDNPKLKISGAFFNRITLAKKEDKEAIADISERLDELKIYVFENLVRDLSGIKKAMKYDMDPVSFGFELKAGKHPEMKGEKATCINAHDDFMSLYQELTQTM
>NZ_CP012855.1|WP_060688779.1|20812_21685_-|hypothetical-protein
MAKLVRKNKPNPDQKRSIVGNGISIDIHKTPPTALEVLPLFEQFIHPLSKSEFSNLKASIEKDGEIFDPIKVWDTGSEKFVIDGHHRLKIAKSLGFDQVPFRSIKALETRDDALEWMAKNQLSRRNITPMMTSFLRGMQLQKSSDVETTQEIAQKLGVSKRTLENDRNVFLALEAIGKENAHWKDYLILTSLEEATISEQEQAALSRVKKGDLEKLGVLLNKGEQIEIPVWLGLKAEEKALKIPLSNLDKYRKQADRWLKSAEKMEQEELQQLKVLLEETLKRVNEKVEF
>NZ_CP012855.1|WP_060688778.1|20127_20634_-|hypothetical-protein
MGLINQAYMNELNVYKIPVQPHVLQYLSKEYAHLQDEEGQFLISRRDPLGIIIQIISTGKTNAAYAIPDMRKQQGFREQRFEMMRVAASARFQNPIISREKINFINNFFDSEFKRALERWILASEVLGATTTESIKNFVDYYQIREEDYGFDSMRKHWQRHRKHRDAV
>NZ_CP012855.1|WP_060688777.1|19460_20087_-|hypothetical-protein
MRKTYLEPLKQPVRLQGGIARLYLVASRRVNIPRDYHGQLSGEETFDPGFGWKLWEVVADSAGLSDALSQVSAGQEHKVSIKFKIFRGGAEQAALLQYASREKFCALLPDRNGQEYVVGSKNIYLHFRLTLKSGDKTGELPYYDCELYSTGPIPVSIRSSGNPDQDPTDPSAPPALVVDGKGKVLAVLQPGQRFELRSGFNYGFRILD
>NZ_CP012855.1|WP_060688776.1|18613_19459_-|hypothetical-protein
MDFQDFLIKWNERFADNITGNISESDLREFAKDITRLDGFEAVSDPKFNGDRMVSREGIPNVNVGGATVTEFLERYFFPAIPPGISLSGGSTFEFTAAETVPVNLEWSVVRNTYPIKTITVDGEEIQATGNNQTGNKSVEAPANESSTFWAEVTDSEDTLRKASTSVSFRHRRFFFATPNNYFSASDQDLALSNTLNNYHLNRSELATSRAKSYSQPCDEEYFYYAYPKSWKAATFKVNGLLNDAVIEKEFQYTNQNGFVETYYLYRSNGKNTATLSIEVS
>NZ_CP012855.1|WP_060688775.1|16499_18614_-|hypothetical-protein
MDYRKEPKGTVLADPVVSHGKGTHFSHKQIGGFWTVPTEEARDSIPGGAVLNTDGWSCGQREHGMEVVVGYGQDRKRYKLEVPNFDAMPDSAKAQYLSNNDYWVLVPEGGSSGSGIIIANTDQDIIDGLSSLQEYDQAILTFFLTGSYGPYKTTFIEVINNLPRNALHEIRFLGTSMEHSIYLSPGQNYSLTYDVNLVFERCKISFTSSFLIELDGSVRLNFVHACMNLGAPGKFVFIGYSNLLGLYGAHLLGAAGSGLELIGCTSGNSVAIAGYGFTISEDALGTDELSEFGVGWYASQYRIGPQAAATITGVENENTWAIPGEGGDGGGGTPVEIPNLDQVLTQGNTSNKGINVAEVEVNSAASLRIKGSDLLIASSGAGIILEEGDDGSQLVFERIMDPGNAYFAPKIGKIELGQEDQRWVKAFFQALDSLSGYIRSLSFDSAFALGYASSNGPLASAFMRVRPQTIPGQTSPQSIIAFESLNVNADMGFSLGMEKLDPDTGNARFIIKHHNKSTTGAIALEIDINGVVKFLKSPTGPYPSADDDLATVKFVKDQLGGGTSPEASTTLRENWYLYYKKVEGGSNTSEKWEWNGLSLTRNETPLSFPHKAKVKSMRIYFRAMEHNEEKEISFYLRGSNGQSRCVAKIPFLVGNRHYHFSGDDFAANNEIAVDEKLNFWISPEFGDGLSQEMEAQVSIEFEAV
>NZ_CP012855.1|WP_060688774.1|15612_16458_-|hypothetical-protein
MIFLEEKYWHLEMHRAEAYRRWLMQGNKLEEAEQLSEHISFAQSTTVQAQFDHRLGMTVATVNNKKKIALIPVMGVMTRAGGACSYGMEYRAEQIYQAEKAGMDGIVLNIDSGGGAANSVEAPSEAVMATKIPLNAAVNQSCCSAAYWVASHADGIYATSERMSVIGSIGTLMVHWDQSQKDEKQFGKISIIRAPQSTQKAKVNSFEAIDAPTMALLNEELSGLTDHFINTVKANRPHIKDAHGVFQGQTFSPLQDEKFGLGLTDGVGSLANIIYQTAIQS
>NZ_CP012855.1|WP_060688773.1|15223_15613_-|hypothetical-protein
MRFFASGKQPEFKAPPLYAKLMGMEEGTVLKISQEEFDRVQQAEAHLETIQEDAEALEANISQLKGEIKQLQSTNTNLEEKLDAAPAAAPTLASIQQQEERQGKEPSFEEQTANLAHNKERDAAFGKED
>NZ_CP012855.1|WP_060688772.1|14251_15217_-|hypothetical-protein
MSINITDILTEYGAYYEKSGQNRNRVKQLLFQGLELMPYMVSNRSDETILKLAKGIIGDLMQPFQKGWTPKGGLTFTPNPLVKERVKVDDQLYPDDIVGSWLGFLEGMETAERKKWPLIRYVIEAYYIPKIQEERNLCHWKGVRKEPVEGQPGMVLDSITGLEKRITDGITAGTVNEVALGMLDDLTIVEQVESFADVIDQSHGGVYKGKALPIFMSAEWSTRYMRAAKKIYGVHPSFKPNDLMVYGTNKKVVGLNNMAGTSRMWSSPKENIIHLRKRNEKAPLHMEELKRQVFLMKDWWEGFGFALNEVVWSSDAANDNP
>NZ_CP012855.1|WP_060688782.1|25082_25763_-|helix-turn-helix-transcriptional-regulator
MDKSLMLNQIKEYYNFRKDGDFADFLGIKSNTLSSWKSRNTFDAERIFAKCNEISAEWLLTGRGEMVPQRKEKTITSYSCGDKNLSHQLIPLYNVEATAGLVNLFDSTQRQEVLDTIKIPNLPKCDGAVFVSGDSMYPLLKSGDIIAYKQILNFWENIFWGEMYLLSIDLEGEEYVTVKFIQKSEEGTDFIRLVSQNQHHAPKDVRLDKVRAMAMIKASIRMNTMN
>NZ_CP012855.1|WP_060688783.1|25977_26340_-|hypothetical-protein
MNDRFKELFNTLSFSRNLKKSTIAEKLESTQQNLSKLSSGDGNPSAKFLFNLVSEFPEVNLNWVFTGKGNMFLSDDVSTMSNSEITALKEENKSLRDRNDELNREMHALKDKMIDILSKK
>NZ_CP012855.1|WP_060688784.1|26450_26684_+|hypothetical-protein
MTETTLKCSSELKDRYDGLRRNQRTALKNAYKESWGDCSDGHFHKLIRGEARSSIQEEWLLKAIEKIIPSVPDRIMA
>NZ_CP012855.1|WP_060688785.1|27339_28215_+|hypothetical-protein
MIDRRLEQARKVTQDRKDPLGSSVSWKIFQLGGKERGLVGHSKWANITENPDPMHVLQKSVRMLLANGYFSKETRFMSNGKVKLPMERIEVYWNQLQGKKLVCTFFPEYALPTEEYMGNTELMSFIERLYHIIETGENTSNLVKQPKKSVGNLMPMTNCFRKLMDVHLHAERLINTYEFEPGRVQDWVRKYTEKHFPDGQPVKKQGRRAAPPVDQVNAVLIKYSQQYSQKQSTMSRFMEFMRRNSEDIFYRDMLIRVQSNKPTDQDIGIFRRWMVHEFGSQKEARLVGALR
>NZ_CP012855.1|WP_060688786.1|28239_28512_+|hypothetical-protein
MNHWPAGYFQNLSLIFYSMMTPKKFTMATRYTDGRKIWNVKFGRINELILQDDQGNVRRPKNIYKGKEMELQVDGMVPVQEEAEKEVADD
>NZ_CP012855.1|WP_063791121.1|28504_28987_+|single-stranded-DNA-binding-protein
MINKAIILGRLGHDPSTKTLQNGTMVTSLNVATTEKYKDRNTGERKESTEWHRVVLWSRLAEIANTYLKKGNLVYLEGKFETRSYQDQSGHTKYATEIVAKEIRLLPQGSHHERPSLPIEASVSRPGAAPSGTPSPAGHQGSLLNAQGQMAGHSEDDLPF
>NZ_CP012855.1|WP_060688787.1|29066_29537_+|DUF4494-domain-containing-protein
MNNWFLCKVKYRKEDDKGILKNIQEQYLVDAMTFTEAESRIHEELGSVIRGEFQVSNMSKSRIVDVFEYPDTDNWHKCKITYILADEEAKKEKKVTNLMIVSAANVKEAYERIQESLASMLVPFQVPEIVETPIVEIFKYKSPDQRVPEGFKPVDS
>NZ_CP012855.1|WP_060688788.1|29589_29769_+|hypothetical-protein
MATVILKKEGLQVEKEIEVCEVKAFKLPDYNEAVIQIKGKKGELAQFRLSKEEAKPIFN
>NZ_CP012855.1|WP_060688789.1|29916_30360_-|hypothetical-protein
MTMKYLFIPALSILLSVTAYSQETNIVLKDGHYVVIMDLFNYTDGDTEICSEDISFSDATFTDGTVKIKKLYSEIPTIGYKFKKTTCPNSITHLSGRFNPQLTNGIKTTEVLEEHIVQNVYGILESIIYVEYYCEKVNGDTPSPTSN
>NZ_CP012855.1|WP_060688790.1|30706_31498_-|nucleotidyltransferase
MSVLSHLNTLGSNLVLSSSETSSINTSITTLEKRLGYYFDNIKSSFVFGSFDRSTILPRSVDENSDIDYMIVFNDGVDFKPQTLLARLKRFAETYYSTSEIYQSSPTLVLNLNHIKFELVPAYENWWSLYIPAPASDYQDWISTDPNQMKANLTDKNGNNDYKIKPLIRVLKYWNVLNYKVYSSYELEKYIIDKSYNWCDNLKDYFFSAVDGLPTYRLPDYKRNKVERLQRNISEVKELLDGGMPFSAEIKLKEELPDCHILK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

5. NZ_CP012860

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

466729 : 538623

Enterobacteria_phage(40.0%)

transposase,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060686923.1\|466729_467626_-\|transposase	transposase	NA	NA	NA	NA
WP_060689252.1\|469521_470088_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_084792955.1\|470158_470530_+	hypothetical protein	NA	NA	NA	NA
WP_060686085.1\|470612_472151_+\|transposase	transposase	U5N3F9	Enterobacteria_phage	2.3e-22	27.9
WP_060686084.1\|472135_472906_+	AAA family ATPase	U5N3V8	Enterobacteria_phage	3.3e-33	33.0
WP_060689253.1\|472969_473566_+	hypothetical protein	NA	NA	NA	NA
WP_063791137.1\|474524_475100_+	hypothetical protein	NA	NA	NA	NA
WP_060689254.1\|475404_475599_+	hypothetical protein	NA	NA	NA	NA
WP_060689255.1\|475683_476475_-	glycine/betaine ABC transporter	NA	NA	NA	NA
WP_060689256.1\|476499_476721_-	hypothetical protein	NA	NA	NA	NA
WP_060689257.1\|477401_480104_+	hypothetical protein	NA	NA	NA	NA
WP_084792956.1\|480504_483267_+	TonB-dependent receptor	NA	NA	NA	NA
WP_060689259.1\|483325_484108_+	hypothetical protein	NA	NA	NA	NA
WP_060689260.1\|484261_484816_+	hypothetical protein	NA	NA	NA	NA
WP_060689523.1\|486018_486633_-	sugar O-acetyltransferase	NA	NA	NA	NA
WP_060689261.1\|487199_488771_+	potassium transporter Kef	NA	NA	NA	NA
WP_060689262.1\|489428_490802_+	hypothetical protein	NA	NA	NA	NA
WP_060689263.1\|490874_493442_-	hypothetical protein	NA	NA	NA	NA
WP_071932222.1\|493468_494773_-	hypothetical protein	A0A0R6PCP6	Moraxella_phage	7.8e-19	29.7
WP_060689265.1\|495834_496083_-	hypothetical protein	NA	NA	NA	NA
WP_060689266.1\|496596_497709_-	hypothetical protein	NA	NA	NA	NA
WP_060689267.1\|498174_499242_-	PorT family protein	NA	NA	NA	NA
WP_060689268.1\|499408_506512_-	T9SS C-terminal target domain-containing protein	NA	NA	NA	NA
WP_060689269.1\|506520_507609_-	hypothetical protein	NA	NA	NA	NA
WP_060689270.1\|508303_508855_-\|transposase	transposase	NA	NA	NA	NA
WP_060689271.1\|509765_510317_-\|transposase	transposase	NA	NA	NA	NA
WP_060689272.1\|510790_511108_-	hypothetical protein	NA	NA	NA	NA
WP_060689273.1\|511116_512199_-	hypothetical protein	NA	NA	NA	NA
WP_060689274.1\|513658_514282_-	hypothetical protein	NA	NA	NA	NA
WP_060689275.1\|514359_515442_-	hypothetical protein	NA	NA	NA	NA
WP_060689276.1\|519069_519309_-	hypothetical protein	NA	NA	NA	NA
WP_060689277.1\|519311_520205_+\|transposase	IS1595 family transposase	NA	NA	NA	NA
WP_060689278.1\|521564_524729_-	hypothetical protein	NA	NA	NA	NA
WP_060689279.1\|524748_525753_-	hypothetical protein	NA	NA	NA	NA
WP_060689280.1\|525755_526304_-	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_060689281.1\|526306_528064_-	hypothetical protein	NA	NA	NA	NA
WP_060689282.1\|528145_528709_+	hypothetical protein	NA	NA	NA	NA
WP_060689283.1\|528892_531874_-	hypothetical protein	NA	NA	NA	NA
WP_060689284.1\|531886_535105_-	hypothetical protein	NA	NA	NA	NA
WP_060689285.1\|535071_536409_-	ATP-binding protein	A0A0R6PCP6	Moraxella_phage	1.7e-16	28.6
WP_060689286.1\|537042_538623_+\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	3.6e-18	24.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

6. NZ_CP012854

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1524 : 9539

Vibrio_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060688707.1\|1524_2109_+	recombinase family protein	K7PGS7	Enterobacteria_phage	2.5e-09	30.7
WP_060688708.1\|2182_3025_-	hypothetical protein	A0A1B1INV8	uncultured_Mediterranean_phage	3.0e-16	38.2
WP_060688709.1\|3005_3779_-	ParA family protein	E2ELL2	Clostridium_phage	1.1e-12	27.3
WP_060688710.1\|4045_4792_-	hypothetical protein	NA	NA	NA	NA
WP_060688711.1\|4793_7787_-	DUF1738 domain-containing protein	A0A1V0EBY3	Caulobacter_phage	3.7e-32	35.9
WP_060688712.1\|7966_8563_-	hypothetical protein	H8YJ90	Vibrio_phage	1.5e-17	35.3
WP_060688713.1\|8559_9000_-	hypothetical protein	A0A2I7QIF0	Vibrio_phage	1.1e-25	51.1
WP_060688714.1\|8999_9539_-	hypothetical protein	I6P8D9	Pseudomonas_phage	3.1e-14	44.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

7. NZ_CP012852

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

56607 : 117366

Diachasmimorpha_longicaudata_entomopoxvirus(25.0%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060685483.1\|56607_57501_-\|transposase	IS1595 family transposase	NA	NA	NA	NA
WP_060687605.1\|57503_57911_+	hypothetical protein	NA	NA	NA	NA
WP_060687608.1\|58045_58480_+	hypothetical protein	NA	NA	NA	NA
WP_060687610.1\|59188_60034_+\|transposase	IS1595 family transposase	NA	NA	NA	NA
WP_060686923.1\|60115_61012_+\|transposase	transposase	NA	NA	NA	NA
WP_060687612.1\|61097_61460_+	hypothetical protein	NA	NA	NA	NA
WP_060687614.1\|61742_63128_+	hypothetical protein	NA	NA	NA	NA
WP_084792857.1\|63964_64837_+	hypothetical protein	NA	NA	NA	NA
WP_060687618.1\|64829_68465_+	hypothetical protein	NA	NA	NA	NA
WP_060687620.1\|68495_68684_+	hypothetical protein	NA	NA	NA	NA
WP_060687621.1\|69014_69236_-	hypothetical protein	NA	NA	NA	NA
WP_060687623.1\|69444_70377_+	hypothetical protein	NA	NA	NA	NA
WP_060687625.1\|70392_71700_+	hypothetical protein	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	4.8e-37	28.5
WP_060687627.1\|72052_72634_+	hypothetical protein	NA	NA	NA	NA
WP_060687629.1\|72900_74343_-	peptidase M19	NA	NA	NA	NA
WP_060687631.1\|74935_75415_+	response regulator	NA	NA	NA	NA
WP_060687634.1\|75761_76523_-	hypothetical protein	NA	NA	NA	NA
WP_060687636.1\|76689_77457_-	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	NA	NA	NA	NA
WP_060687638.1\|77456_78152_-	ATP-binding protein	NA	NA	NA	NA
WP_060687640.1\|78243_78912_-	nitroreductase family protein	NA	NA	NA	NA
WP_060687641.1\|78915_79692_-	hypothetical protein	NA	NA	NA	NA
WP_084792704.1\|80296_81583_+	hypothetical protein	NA	NA	NA	NA
WP_060687643.1\|83874_85518_-	long-chain fatty acid--CoA ligase	A0A1V0SBX8	Catovirus	1.5e-30	25.5
WP_060687645.1\|86143_87982_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_060685295.1\|88259_89324_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_060687646.1\|89597_90479_-	hypothetical protein	NA	NA	NA	NA
WP_071932197.1\|91652_92603_-\|transposase	transposase	NA	NA	NA	NA
WP_084792858.1\|93005_94847_-	hypothetical protein	A0A1V0SGX0	Hokovirus	1.2e-46	30.7
WP_060687650.1\|95099_96548_-	SusD/RagB family nutrient-binding outer membrane lipoprotein	NA	NA	NA	NA
WP_060687651.1\|96596_99845_-	SusC/RagA family TonB-linked outer membrane protein	NA	NA	NA	NA
WP_060687653.1\|100390_101257_-	VOC family protein	NA	NA	NA	NA
WP_060687655.1\|101555_102338_-	hypothetical protein	NA	NA	NA	NA
WP_060687656.1\|102577_102775_+	hypothetical protein	NA	NA	NA	NA
WP_060687661.1\|103422_103638_+	hypothetical protein	NA	NA	NA	NA
WP_060687663.1\|104164_105088_+	hypothetical protein	NA	NA	NA	NA
WP_060687664.1\|105282_105918_+	hypothetical protein	NA	NA	NA	NA
WP_060687666.1\|105914_106679_+	ATP-binding protein	NA	NA	NA	NA
WP_063790977.1\|106662_107433_+	DNA-binding response regulator	NA	NA	NA	NA
WP_060687668.1\|107429_107732_-	hypothetical protein	NA	NA	NA	NA
WP_060687670.1\|107883_108093_-	hypothetical protein	NA	NA	NA	NA
WP_060687672.1\|108191_108512_+	hypothetical protein	NA	NA	NA	NA
WP_060687674.1\|111453_113088_-	hypothetical protein	NA	NA	NA	NA
WP_060687676.1\|113418_113949_-	DUF3124 domain-containing protein	NA	NA	NA	NA
WP_060687677.1\|114070_115756_-	gamma-glutamyltransferase	NA	NA	NA	NA
WP_060687678.1\|116397_117366_-\|protease	zinc metalloprotease	A0A2K9L5D3	Tupanvirus	3.6e-21	32.8

DBSCAN-SWA_2

612205 : 674330

Staphylococcus_prophage(18.18%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060685439.1\|612205_613174_-\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	4.8e-42	37.9
WP_060688054.1\|613425_614250_-	hypothetical protein	A0A1V0SCG0	Catovirus	2.1e-14	24.9
WP_060688055.1\|614230_615115_-	hypothetical protein	NA	NA	NA	NA
WP_084792883.1\|615181_615538_-	hypothetical protein	NA	NA	NA	NA
WP_060688057.1\|616213_617776_-	flotillin family protein	A0A2I2L4B2	Orpheovirus	1.9e-16	24.0
WP_060688058.1\|617782_618358_-	hypothetical protein	NA	NA	NA	NA
WP_060688059.1\|618906_620394_-	deoxyribodipyrimidine photolyase	E3T4R9	Cafeteria_roenbergensis_virus	6.0e-84	36.4
WP_060688060.1\|620448_621921_-	deoxyribodipyrimidine photo-lyase	A0A1V0S949	Catovirus	5.9e-23	30.7
WP_060688612.1\|621913_623056_-	deoxyribodipyrimidine photolyase	NA	NA	NA	NA
WP_060688061.1\|623450_624161_+	hypothetical protein	NA	NA	NA	NA
WP_060688062.1\|625030_626296_-	glycoside hydrolase	NA	NA	NA	NA
WP_060688063.1\|626870_627095_-	hypothetical protein	NA	NA	NA	NA
WP_063790994.1\|627341_628799_-	hypothetical protein	NA	NA	NA	NA
WP_060688064.1\|629336_629534_-	hypothetical protein	NA	NA	NA	NA
WP_060688065.1\|629831_630362_-	DUF1697 domain-containing protein	NA	NA	NA	NA
WP_060688066.1\|630595_630868_+	hypothetical protein	NA	NA	NA	NA
WP_060688067.1\|631108_631801_-	DNA-binding response regulator	W8CYM9	Bacillus_phage	5.9e-26	33.0
WP_060688068.1\|631797_633165_-	sensor histidine kinase	NA	NA	NA	NA
WP_060688069.1\|633600_635298_-	hypothetical protein	NA	NA	NA	NA
WP_084792884.1\|636222_638634_+	TonB-dependent receptor	NA	NA	NA	NA
WP_060688071.1\|639236_639497_-	addiction module antidote protein, HigA family	NA	NA	NA	NA
WP_060688072.1\|640392_640710_-	hypothetical protein	NA	NA	NA	NA
WP_060688073.1\|640907_642026_-	hypothetical protein	NA	NA	NA	NA
WP_060688074.1\|642186_643488_-	sodium:proton antiporter	NA	NA	NA	NA
WP_060688075.1\|643926_645360_+	hypothetical protein	NA	NA	NA	NA
WP_060688076.1\|645977_646820_+	naphthoate synthase	NA	NA	NA	NA
WP_060688077.1\|646956_647676_+	short-chain dehydrogenase	NA	NA	NA	NA
WP_060688078.1\|647763_648342_-	hypothetical protein	NA	NA	NA	NA
WP_060688079.1\|648660_649212_-	hypothetical protein	NA	NA	NA	NA
WP_060688080.1\|649663_650959_-	PepSY domain-containing protein	NA	NA	NA	NA
WP_060688081.1\|650967_653301_-	TonB-dependent siderophore receptor	NA	NA	NA	NA
WP_060686085.1\|653690_655229_+\|transposase	transposase	U5N3F9	Enterobacteria_phage	2.3e-22	27.9
WP_060686084.1\|655213_655984_+	AAA family ATPase	U5N3V8	Enterobacteria_phage	3.3e-33	33.0
WP_060688082.1\|656412_657036_-	hypothetical protein	NA	NA	NA	NA
WP_060688083.1\|657676_658219_+	hypothetical protein	NA	NA	NA	NA
WP_060688084.1\|658605_659679_-	ATPase	A0A292GDQ9	Xanthomonas_phage	5.9e-33	38.5
WP_060688085.1\|660182_661622_+	hypothetical protein	A0A2P0VMN7	Tetraselmis_virus	6.1e-25	25.9
WP_060688086.1\|662000_662243_+	hypothetical protein	NA	NA	NA	NA
WP_060688087.1\|662433_662754_+	hypothetical protein	NA	NA	NA	NA
WP_060688088.1\|662765_663008_+	hypothetical protein	NA	NA	NA	NA
WP_060688089.1\|663120_664302_+	hypothetical protein	NA	NA	NA	NA
WP_060688090.1\|664535_664736_-	hypothetical protein	NA	NA	NA	NA
WP_060688091.1\|664753_665722_+\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	8.2e-42	37.3
WP_060688092.1\|666367_666589_+	hypothetical protein	NA	NA	NA	NA
WP_060684959.1\|666585_667479_-\|transposase	IS1595 family transposase	NA	NA	NA	NA
WP_060684959.1\|667562_668456_-\|transposase	IS1595 family transposase	NA	NA	NA	NA
WP_060688093.1\|669277_669637_-	hypothetical protein	NA	NA	NA	NA
WP_060688094.1\|669887_672557_+	hypothetical protein	NA	NA	NA	NA
WP_060688095.1\|672788_674330_+\|transposase	DDE transposase	NA	NA	NA	NA

DBSCAN-SWA_3

924459 : 1009332

Acidithiobacillus_phage(25.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060688248.1\|924459_925590_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_084792894.1\|926525_933518_-	PKD domain-containing protein	NA	NA	NA	NA
WP_060688250.1\|933445_934567_-	hypothetical protein	NA	NA	NA	NA
WP_060688251.1\|934855_935080_+	hypothetical protein	NA	NA	NA	NA
WP_060688252.1\|935276_935510_-	hypothetical protein	NA	NA	NA	NA
WP_060688253.1\|935615_936749_-	hypothetical protein	NA	NA	NA	NA
WP_060688254.1\|937130_937352_+	hypothetical protein	NA	NA	NA	NA
WP_063791013.1\|938454_941421_+	TonB-dependent receptor	NA	NA	NA	NA
WP_060688256.1\|941434_942916_+	RagB/SusD family nutrient uptake outer membrane protein	NA	NA	NA	NA
WP_060688257.1\|944550_944787_+	hypothetical protein	NA	NA	NA	NA
WP_060686999.1\|944783_945947_-	hypothetical protein	A0A218MNH3	uncultured_virus	2.7e-63	38.5
WP_060688258.1\|946294_948112_+	hypothetical protein	NA	NA	NA	NA
WP_060688259.1\|948754_951535_+	hypothetical protein	NA	NA	NA	NA
WP_084792895.1\|952100_952790_-	hypothetical protein	NA	NA	NA	NA
WP_060688261.1\|952794_956430_-	hypothetical protein	NA	NA	NA	NA
WP_060688262.1\|956494_957421_-	cobalamin biosynthesis protein CbiX	NA	NA	NA	NA
WP_060688263.1\|958064_960995_+	TonB-dependent receptor	NA	NA	NA	NA
WP_060688264.1\|961019_962672_+	RagB/SusD family nutrient uptake outer membrane protein	NA	NA	NA	NA
WP_060688265.1\|963050_963266_+	hypothetical protein	NA	NA	NA	NA
WP_060688266.1\|963456_963642_-	hypothetical protein	NA	NA	NA	NA
WP_060688267.1\|963925_964867_+	hypothetical protein	NA	NA	NA	NA
WP_060688268.1\|964915_966157_-	hypothetical protein	NA	NA	NA	NA
WP_060688269.1\|967865_969107_-	hypothetical protein	NA	NA	NA	NA
WP_060688270.1\|970400_971987_-	hypothetical protein	NA	NA	NA	NA
WP_060688271.1\|972483_973050_-	hypothetical protein	NA	NA	NA	NA
WP_060688272.1\|973042_974323_-	DUF2157 domain-containing protein	NA	NA	NA	NA
WP_060688273.1\|974585_974909_+	hypothetical protein	NA	NA	NA	NA
WP_060688274.1\|974918_975887_-\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	2.4e-41	37.6
WP_060688275.1\|975904_976354_+	hypothetical protein	NA	NA	NA	NA
WP_060688276.1\|976377_976593_-	hypothetical protein	NA	NA	NA	NA
WP_060688277.1\|976646_977741_-	hypothetical protein	NA	NA	NA	NA
WP_060688278.1\|977759_978062_-	hypothetical protein	NA	NA	NA	NA
WP_060688279.1\|978244_979117_+	hypothetical protein	NA	NA	NA	NA
WP_060688280.1\|979335_980883_+	hypothetical protein	K4I413	Acidithiobacillus_phage	1.8e-62	32.0
WP_060688281.1\|980887_981610_+	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	1.3e-39	38.5
WP_060688282.1\|981905_982178_+	hypothetical protein	NA	NA	NA	NA
WP_060688283.1\|983013_984042_-\|transposase	transposase	A0A1B1P773	Bacillus_phage	4.4e-09	23.4
WP_060688284.1\|984083_984395_-\|transposase	transposase	NA	NA	NA	NA
WP_060688285.1\|984866_986795_+	T9SS C-terminal target domain-containing protein	NA	NA	NA	NA
WP_060688286.1\|986984_987593_-	hypothetical protein	NA	NA	NA	NA
WP_060688287.1\|988170_989775_+	fumarate hydratase	NA	NA	NA	NA
WP_060688288.1\|989798_990023_+	hypothetical protein	NA	NA	NA	NA
WP_060688289.1\|991120_993253_-	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	4.7e-05	23.7
WP_060688290.1\|993252_994566_-	biotin carboxylase	NA	NA	NA	NA
WP_060688291.1\|994569_997197_-	hypothetical protein	M4ZS56	Bacillus_phage	3.9e-09	49.2
WP_084792896.1\|997803_998424_-	hypothetical protein	NA	NA	NA	NA
WP_060688293.1\|998526_999033_+	hypothetical protein	NA	NA	NA	NA
WP_060688294.1\|999530_999812_-	hypothetical protein	NA	NA	NA	NA
WP_060688295.1\|999995_1001246_-	DUF1566 domain-containing protein	NA	NA	NA	NA
WP_084792897.1\|1001254_1002589_-	hypothetical protein	NA	NA	NA	NA
WP_060688297.1\|1003039_1003321_-	hypothetical protein	NA	NA	NA	NA
WP_060688298.1\|1003518_1004673_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_060688299.1\|1004838_1005423_+	linear amide C-N hydrolase	A0A2K9L5Y5	Tupanvirus	4.8e-13	28.8
WP_084792898.1\|1005520_1005901_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_060688301.1\|1006032_1007013_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_060685483.1\|1007461_1008355_-\|transposase	IS1595 family transposase	NA	NA	NA	NA
WP_060685483.1\|1008438_1009332_-\|transposase	IS1595 family transposase	NA	NA	NA	NA

DBSCAN-SWA_4

1330607 : 1417376

Cronobacter_phage(25.0%)

transposase,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060688470.1\|1330607_1331597_+\|transposase	transposase	NA	NA	NA	NA
WP_084792907.1\|1331603_1332287_+	hypothetical protein	NA	NA	NA	NA
WP_060688629.1\|1333307_1335734_-	S9 family peptidase	NA	NA	NA	NA
WP_060688472.1\|1336222_1336555_+	hypothetical protein	NA	NA	NA	NA
WP_060688473.1\|1336647_1336866_+	hypothetical protein	NA	NA	NA	NA
WP_060688474.1\|1336867_1339150_-	T9SS C-terminal target domain-containing protein	K4FB16	Cronobacter_phage	3.4e-09	36.7
WP_060688630.1\|1340437_1341862_-	metal-independent alpha-mannosidase	NA	NA	NA	NA
WP_060688475.1\|1341919_1344541_-	hypothetical protein	NA	NA	NA	NA
WP_063791023.1\|1345751_1348877_+	SusC/RagA family TonB-linked outer membrane protein	NA	NA	NA	NA
WP_060688477.1\|1348879_1350817_+	SusD/RagB family nutrient-binding outer membrane lipoprotein	NA	NA	NA	NA
WP_060688478.1\|1351095_1351842_+	copper homeostasis protein CutC	NA	NA	NA	NA
WP_060688479.1\|1351849_1353085_+	hypothetical protein	NA	NA	NA	NA
WP_060688248.1\|1353551_1354682_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_060688631.1\|1354901_1356110_+	hypothetical protein	NA	NA	NA	NA
WP_060688480.1\|1356607_1357711_-	alkene reductase	NA	NA	NA	NA
WP_060688481.1\|1358957_1359761_-	hypothetical protein	NA	NA	NA	NA
WP_060688482.1\|1359803_1360655_-	hypothetical protein	NA	NA	NA	NA
WP_060688483.1\|1361095_1363897_+	T9SS C-terminal target domain-containing protein	NA	NA	NA	NA
WP_060688632.1\|1364765_1366475_-\|tRNA	glutamine--tRNA ligase/YqeY domain fusion protein	A0A222YZ70	Escherichia_phage	1.0e-180	58.5
WP_060688484.1\|1367556_1369218_+	alkaline phosphatase family protein	NA	NA	NA	NA
WP_060688485.1\|1369624_1369804_-	hypothetical protein	NA	NA	NA	NA
WP_060688486.1\|1369933_1371787_+	alpha-amlyase	NA	NA	NA	NA
WP_060688487.1\|1372759_1376035_+	SusC/RagA family TonB-linked outer membrane protein	NA	NA	NA	NA
WP_060688488.1\|1376068_1377508_+	SusD/RagB family nutrient-binding outer membrane lipoprotein	NA	NA	NA	NA
WP_060688489.1\|1378060_1378582_-	N-acetyltransferase	NA	NA	NA	NA
WP_060688490.1\|1378726_1379647_-	DUF697 domain-containing protein	NA	NA	NA	NA
WP_060688491.1\|1379908_1381219_-	hypothetical protein	NA	NA	NA	NA
WP_060688492.1\|1381578_1381839_+	hypothetical protein	NA	NA	NA	NA
WP_060688493.1\|1381931_1382234_+	hypothetical protein	NA	NA	NA	NA
WP_060688633.1\|1382363_1383281_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_060688494.1\|1384098_1385067_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_060688495.1\|1386565_1393966_+	T9SS C-terminal target domain-containing protein	A0A1B0T6A2	Bacillus_phage	2.9e-22	30.3
WP_060688496.1\|1394021_1397153_+	TonB-dependent receptor	NA	NA	NA	NA
WP_084792908.1\|1397159_1398632_+	RagB/SusD family nutrient uptake outer membrane protein	NA	NA	NA	NA
WP_060688498.1\|1399163_1400189_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_060688499.1\|1400305_1400644_-	hypothetical protein	NA	NA	NA	NA
WP_060688500.1\|1400680_1401802_-	ATP-dependent helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	3.7e-54	34.2
WP_060688501.1\|1402323_1402746_-	hypothetical protein	NA	NA	NA	NA
WP_060688502.1\|1403423_1403972_+	hypothetical protein	NA	NA	NA	NA
WP_084792909.1\|1404275_1404758_-	hypothetical protein	NA	NA	NA	NA
WP_060688504.1\|1405188_1407084_+	sodium:solute symporter	NA	NA	NA	NA
WP_060688505.1\|1407095_1408067_+	glycosidase	NA	NA	NA	NA
WP_060686527.1\|1408310_1409438_+\|transposase	IS4/IS5 family transposase	NA	NA	NA	NA
WP_060688506.1\|1410079_1411207_+	hypothetical protein	NA	NA	NA	NA
WP_063791024.1\|1411991_1412897_+\|protease	CPBP family intramembrane metalloprotease domain-containing protein	NA	NA	NA	NA
WP_060688508.1\|1413409_1414468_-	lactonase family protein	NA	NA	NA	NA
WP_060688509.1\|1415016_1415451_+	hypothetical protein	NA	NA	NA	NA
WP_060688510.1\|1415762_1417376_+\|transposase	DDE transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage