CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP013126	Acidipropionibacterium acidipropionici strain CGMCC 1.2230 chromosome, complete genome	11 crisprs	csa3,WYL,DEDDh,cas3,DinG	0	4	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP013126_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013126_1

223992-224078

Orphan

Consensus_repeat	Method
CCGTCCCACCGAGTCCCGGACCTCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013126_1

>merge|NZ_CP013126|1|223992-224078|CRISPRCasFinder
CCGTCCCACCGAGTCCCGGACCTCACAGGTCGCAGGACCACGATGAGCCGGGAGAGGAGGTCCGTCCCACCGTGTCCCGGACCTCAC

>NZ_CP013126|1|1|223992-224078|CRISPRCasFinder
CCGTCCCACCGAGTCCCGGACCTCAC	AGGTCGCAGGACCACGATGAGCCGGGAGAGGAGGT
CCGTCCCACCGTGTCCCGGACCTCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013126.1\|WP_015069487.1\|232048_234646_-\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529
NZ_CP013126.1\|WP_015069498.1\|219353_220061_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP013126.1\|WP_015069490.1\|228812_230162_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NZ_CP013126.1\|WP_051281536.1\|236195_237101_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP013126.1\|WP_015069491.1\|227650_228748_+\|PfkB-domain-containing-protein	unknown	unknown	gnl\|CDD\|238917
NZ_CP013126.1\|WP_027588481.1\|211240_214399_+\|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223683
NZ_CP013126.1\|WP_015069494.1\|224187_225120_-\|DUF559-domain-containing-protein	unknown	unknown	gnl\|CDD\|225408
NZ_CP013126.1\|WP_154662003.1\|214781_217358_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_015069495.1\|223234_223771_-\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|223149
NZ_CP013126.1\|WP_076692615.1\|210136_211240_+\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341156
NZ_CP013126.1\|WP_015069486.1\|234780_236163_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270451
NZ_CP013126.1\|WP_015069493.1\|225409_226759_-\|glycoside-hydrolase	unknown	unknown	gnl\|CDD\|133432
NZ_CP013126.1\|WP_015069488.1\|231133_231931_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP013126.1\|WP_015069502.1\|217485_217602_-\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NZ_CP013126.1\|WP_051143621.1\|220108_220918_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|365804
NZ_CP013126.1\|WP_095532344.1\|217841_218105_-\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NZ_CP013126.1\|WP_015069492.1\|226755_227517_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP013126.1\|WP_138575432.1\|230291_231134_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP013126.1\|WP_015069496.1\|220914_223089_+\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
NZ_CP013126.1\|WP_015069499.1\|218255_219122_-\|NmrA-family-NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|187578

Protein	Function_ID	Function_description	E-value
NZ_CP013126.1\|WP_015069487.1\|232048_234646_-\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NZ_CP013126.1\|WP_015069498.1\|219353_220061_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.31455e-11
NZ_CP013126.1\|WP_015069490.1\|228812_230162_+\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.48996e-64
NZ_CP013126.1\|WP_051281536.1\|236195_237101_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.46742e-85
NZ_CP013126.1\|WP_015069491.1\|227650_228748_+\|PfkB-domain-containing-protein	gnl\|CDD\|238917	cd01942, ribokinase_group_A, Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.	7.57352e-47
NZ_CP013126.1\|WP_027588481.1\|211240_214399_+\|type-I-restriction-endonuclease-subunit-R	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	1.04865e-154
NZ_CP013126.1\|WP_015069494.1\|224187_225120_-\|DUF559-domain-containing-protein	gnl\|CDD\|225408	COG2852, COG2852, Very-short-patch-repair endonuclease [Replication, recombination, and repair].	0.000101626
NZ_CP013126.1\|WP_138575432.1\|230291_231134_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	8.36654e-72
NZ_CP013126.1\|WP_015069495.1\|223234_223771_-\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	4.93805e-29
NZ_CP013126.1\|WP_015069492.1\|226755_227517_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.38825e-73
NZ_CP013126.1\|WP_015069486.1\|234780_236163_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.93988e-90
NZ_CP013126.1\|WP_015069493.1\|225409_226759_-\|glycoside-hydrolase	gnl\|CDD\|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	5.59186e-174
NZ_CP013126.1\|WP_015069488.1\|231133_231931_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.64651e-69
NZ_CP013126.1\|WP_051143621.1\|220108_220918_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|365804	pfam00005, ABC_tran, ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide as in CFTR, or belong in different polypeptide chains.	4.33319e-18
NZ_CP013126.1\|WP_076692615.1\|210136_211240_+\|restriction-endonuclease-subunit-S	gnl\|CDD\|341156	cd17267, RMtype1_S_EcoAO83I-TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S.EcoAO83I TRD1-CR1 and S.AbaB8342I TRD2-CR2. Escherichia coli strain A0 34/86 S subunit (S.EcoAO83I) recognizes 5'... GGANNNNNNNNATGC ... 3, and Acinetobacter baumannii B8342 S subunit (S.AbaB8342I) recognizes 5'... TTCANNNNNNTCC ... 3. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example S.AbaB8342I-TRD1 recognizes TTCA/TGAA and S.AbaB8342I-TRD2 recognizes GGA/TCC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It also includes TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases such as Type IIG restriction enzyme/N6-adenine DNA methyltransferases from Thermus scotoductus RFL1 (RM.TstI) and Acinetobacter lwoffi Ks 4-8 (RM.AloI), as well as type I DNA methyltransferases such as Sideroxydans lithotrophicus ES-1 Type I N6-adenine DNA methyltransferase (M.SliESORF1090P). RM.TstI recognizes 5' ... CACNNNNNNTCC ... 3' and RM.AloI recognizes 5' ... GAACNNNNNNTCC ... 3'.	9.91942e-75
NZ_CP013126.1\|WP_015069496.1\|220914_223089_+\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	6.01399e-73
NZ_CP013126.1\|WP_015069499.1\|218255_219122_-\|NmrA-family-NAD(P)-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.86218e-84

>NZ_CP013126.1|WP_015069495.1|223234_223771_-|Hsp20/alpha-crystallin-family-protein
MALVEYNPFRGLDRFFDQFAQMASGDSRLMPMDLYRDGDDFVARMDLPGVDPSSIDIDVHDNVLTVRAERKANDVKHDEHSGWVSRERSYGSFARQLSLDSSLDASRITADYTDGELVLTIPVAEEAKPQKIQVTQGQHRAVTVGTDESDASEQKAETSTDAKAAPEPMGPSEPEHHN
>NZ_CP013126.1|WP_015069496.1|220914_223089_+|YhgE/Pip-domain-containing-protein
MTSFLRLIQFEFRRFKGKSKLALIFILVIPLLYGGVYLHANWDLYNNTDKVKIAVVNHDRPASYAGATVDGGAAFEQALKKQGTFDWQFLGTDDDKANEGLRKGDYYMVINVPSNFSTNIVSAGNFKPARASLQLHRDDANGFIIGLLTSQVDNAVGKTLDATVSQTYFDALFVNLGTIKSSLGTASSGAKTLDTNLATATKGVKTMNDSVLGATKSLSGLSAATTKNSDALNNIDTASTKLSTAMTQAQGGVNTISSAAGDLTGDAKKMTSSTAALADKAAKDYPTIKAKAANLVTATGRMQNSGTIQTQTDINASLTSLASLEASHPDLAKDSDYVALRKQLNAAATANTTVTANVNTVVNASAGLNLQLNQSDLDKLAADAKKDAANLNADADKVNKGVQQLNSAMKTADDGVQNIDKGVKQATSAGRDLLAVAPKAIDGVMQLSNALGSLNTAMPQLSNGMHTLATGLDKGNKQIPDLSDRQRTNLADVMSSPVDITQTVDHSAKYYGRGLAPMFLSIAMWIACISTFLVVRTASGRSLTGRANSLKIAMMGFGPLATIGLAGSFLMVAGVWLLLGLDPVHPWLFIGFVTVTSLAWMALAYWIRLILGSPQTAVFLILLVLQLPTCGGTFPVTMLPPFYQKLSVIMPMKYSVDTFRALISGGQMSTVGLGFGVQAGILAASIGLIVWLIRRHKIFRMRDLHPPMVTSTTTADYAFSVRPR
>NZ_CP013126.1|WP_051143621.1|220108_220918_+|ATP-binding-cassette-domain-containing-protein
MSPTGASPSGSGLVLHARGLTASGSRGVIFGPVDLDLSPRQLTVIHGPKGTGKSALLLALTGRFRRTRGTLIIDGIDAIADPYRAIRRTSVATIGDYVQPEDRLTLAESVAERSYLDSVPLAHAEDRMRRIEELVGYTIERSTELEQLTAMERAIASVALAMIRPSKLIVIDDADVMVPHAEQKELFEIFLRMTELDDSAIVATTVDDDMAPPGSIDIALPARHRAKVHPISGEQVAASPATPDDADDSADGDPSHAPSSTQATEVTDS
>NZ_CP013126.1|WP_015069498.1|219353_220061_+|TetR/AcrR-family-transcriptional-regulator
MQTATHPDLTVETDNTTRDDAPGAVSPADAPAHAPLPGRPSHDSVRAKILEAAAANFEEFGYAGTNLRKIASDAGFTKGAVYSNFGSKPDLFCQVATERMSGAGADVFASLTPVLATAADRRELVEGLGRALTQSLLGYTAWELIIAEFRGLAPTDPQVAAGYAALSRERIDRLIELLVTSPLLAELADPDLRSLAAGALGLLNVMAVDHIAAPEVYTEDFITEIVTHAVEGLIR
>NZ_CP013126.1|WP_015069499.1|218255_219122_-|NmrA-family-NAD(P)-binding-protein
MTIAITGATGQLGGLVIDSLLARVPATEIVALARNTEKAAGLASRGIDVRHFDYNQPEGLEPALKGVDRLLLISGNAVGQRIPQHKAVIDAAVAADVEFIAYTSFLHTEEASIIAVAPEHKETEKLLAAAPIKVGLLRNGLYTENFIPQAQQAAETGTLLTSAGAGRISSAVRKDFAEAAAAVISAESADDAVYELSGDESFTYGDLANVIAELTGKPVALKNVSAEEHEQILKAAGVPEFGIGFATSTDLAIKEGELFDEHPGTLSKLIGHPTTSLKDALAPALTQG
>NZ_CP013126.1|WP_095532344.1|217841_218105_-|ribbon-helix-helix-protein,-CopG-family
MPMTEMINGRPVTEDQIAEWAAEAEAGYDVEKLRRRGRGRPGRGAQPSQAVAVRLTPDELAEVDERAAAAHKTRSAYIRGVLLPESA
>NZ_CP013126.1|WP_015069502.1|217485_217602_-|ribbon-helix-helix-protein,-CopG-family
MTVRLSESELDAVMARANREHRSRSDAIREALDEWAHA
>NZ_CP013126.1|WP_154662003.1|214781_217358_+|hypothetical-protein
MEIQGTLANRLDEALCASGTHWSDPTDHLSRALRLVELTYPAIAATIEDADRAQLCESWAQQRDATVRKVLYELAGPDAAFSAQDLAQVLRQRSAARRTVRLQAFNTDEAALRSYLERIHMPNVPSGSVVVLQGDFGSGKSEVAETWHRACINELAMGDIAPIPVWFNASAMTGMSLENALDAQTGHAWRRGQGASITIDGLDEIEPATAQALLDASRVLAKTYTSIRVLLTSRPGILTPTTDEEQAIDLLSASDALDLVEAIGGERRETWRWTTDMRETVRRPFFALAAGIMLASGSVPDGEADLIRNLVEHALATGAERQAVTSSTTRGVLEKLAVRLTHSGRDGLSFSDRQVARSSRLVADGPQGSVIFSLPIFQHWFAAQAILAGDVPPEDIVATRQSFVRWRWAAAVAVMSLTDDSQIDELLGTWVSGNPGAAAWIIREAFSGRGNFHTDADGSLDAISSRRRILRALRTWTNGLGPFAPGLLPDSLVHGPVGLGVAVSGRCINIAFAEPSPKSDYVTELPEGIHPLSWGSISKPAWIPWMCGGVPRGSAWPWTMTRELIARETLKKLSNDPHLGTSDGIWTQERRFDLSRVLLRRGRQSLDPLPADEVRTRAVELFESLGGNRKSSVTFNLGGSYSGAELEDLILSIDTNRPSVIASPLPQPDLNPPPPSSWIWEWYSQQRIMEFEVAVYSRACKAYDEALDNAFARLGWSMSSSILAPFGVVMRLNLNDDDSERRLRDRWGSISLSLTRVPMALLPELAPTDPEPIWSTDRRVVISRSEVSLETAYFSWVLERIGSWLQMQERELIGGLSWSTTIANQMSKVRPACDIAAKWLYDDLKKTGLGEGTFPQLR
>NZ_CP013126.1|WP_027588481.1|211240_214399_+|type-I-restriction-endonuclease-subunit-R
MISEADWEADMLDWLGELGWEPGTGSDIDGQRRSAADLVLQTDLLNALRRLNPDVPDQRLAEAAAEITAPKSQDAIAENERLHDFLVHGFRGLTYIDTQGREQTPTLRLLSDNPTENTYRAIHQVTIVSGQHSRRFDVVLYVNGLPLVIAELKKASASATITDAYNQLQTYLAEFPTAFRTVVATVISDGLEAKYGTPFTPSNHFTPWNLNDQGDRIDDDNEGLQHLCYGLLEPRRFVDIVKHFVTFEHDDGVTKKIAKPHQYMAVRKAVERTLTAVDSNGKAGVVWHTQGSGKSMEMELYANLVMSDPKLLNPTIVVITDRRDLDGQLYDTFARSTLLPEKPTQIRRRQELRDSLSNRNSGGIYFTTLQKFGLTDEERGRGADHPLLTDRHNVIVIVDEAHRSHYDDLDGYARHLKDALPHGTLIAFTGTPISEPERNTRDVFGDYIDIYDLTQAVEDGATVPVHFEPRLVKVSLASELTPEEIDEAADKETAGLDDSERERIERTVAVINAIYGAPERLEALARDIVTHWERRRDLMDEYLQPSDPDDDAVPHGKGIIVCSTREIAAKLYDEIVKLRPGWHSDDDRTGVIKVVYSGSASDPDPIQKHVRRESQNKAIKNRLKNVNDELELVIVKDMMLTGFDAPAWHTMYLDRPLKGAQLMQALARVNRIFRGKKDGLLVAYAPLADNLKKALGEYTTRDAQNEPVGKNISEAVRETRRLVEALRALLAGCDWRPVLAGGGRRAAKDAVSMAVNYLRSPSTPGNRVEEGQATLKERFRMLSGQLGRMWALSAGSEHLDDLRHEIRFYEEVRGWMAKWDAREREALGQPIPEDVRRMLKGLVAEATAAGEVTDIYAEAGIDLPDLRELTPEKAEELARSDKPQLAIEALRDMLMAEAKAATAHNLTRRTMFSERINGLMIRYTNQQLTSVEAITLILGMAGDVAAEAARGERFNPPLSADELAFYDAVSQNDSAVELMGDDVLAEIARELVGVMQRDTRTDWRVRADMQAKLRVSIKRLLRKYKYPPDKQPAAVKRVIDQMEELAPRYPTK
>NZ_CP013126.1|WP_076692615.1|210136_211240_+|restriction-endonuclease-subunit-S
MLRKLTDCCESIDYGFTQSSSAEEIGPHFLRITDIDPECIDWESVPYCEASPAERNKYALAAGDIVVARTGASTGNSRWIESPHGSVFASYLVRLVARPEVNSRYLSYVLKGAQWNHYVSSISSSKSAQPNMSASAMGQFTFEIHSLPEQQAIAEVLGALDDKIAANRKLVTTSLTLAEAVHDLALSDEQRPLGDFMEFAYGKSLPATRRIPGEVPVVGSGGVTGSHDEALVNRPGIVVGRKGSMGTVRWMDEPFFPIDTTFYVTNKTGIPDQFWYFSLKQARFEGLNSDSAVPGLNREAALEQLTRTPSESGIKRFEDFALPLFELATANRRESQTLSQLRDTLLPALMDGTIRVKDAERLTEEAV
>NZ_CP013126.1|WP_015069494.1|224187_225120_-|DUF559-domain-containing-protein
MKARTVPPRSLLIFAGEQCDVVTMRQALEGGMTRDGVRGMVHSGRWVRLSSGVFSIGPPTWEQWASAGVVIGGPGSAVGGKAAAFLHGMGPQPEIIDIWAPRGTSYKWRASPHPWDFHRGTRKSIGRPPRLTVEETVLELCSAGGADNVNGWLGKALSDYRTTPDRLRAAIVRAPTLPNRRLILEGIDAVSIGAQSSMEVRYLRDVEKAHGLPRGVRQKSVVAHKFTDVIYEQYKLVVELDGLVGHFGEGENHDTWRDSELLLRGIESMRFGWADVTVRPCEVAAMVAGVLQVRGWDGQMQLCPSCPVPR
>NZ_CP013126.1|WP_015069493.1|225409_226759_-|glycoside-hydrolase
MKLAILGGGGFRVPLVHGAVLDQMGPEDGTRIDEIWLHDVSSERLDTMVRVLRGQVAGRPGAPSLHATISLPEAVAGADFVFSAIRVSGLEGRCCDERVALDMGLLGQETTGAGGLIYGLRTLPEAMRIARVVAEEAPGAWVINFTNPAGMITQAMQQVLGPRVIGICDSPIGLGRRAAQALGLDPAATRFGYSGLNHLGWLQSLTVQGRDVLPDLLARPDLLKGTEEGRLFGPEWLGMLGAIPNEYLYYYYFNRDAVAAIRGAAETRGEYLRRTQAQFYRDAAASDDPYRVWVEAHHGRDASYMAEARAEGEERDEADMAAGGYEGVAVAIMRAISAGERASIILNVRNGSALAGLPADAVVEVPCVVDGSGPVPLEPEQLTGHMLGLAATVKECEMGIISAAESGSDAEAVRALAVHPLVDSVTAAGELLAGYRAAIPEVEAVFSGR
>NZ_CP013126.1|WP_015069492.1|226755_227517_-|DeoR/GlpR-transcriptional-regulator
MKAIRQGQIQAMLARHEICTVAELVRGLGVSPSTIRRDLADLAARGEVVRERGGARSADSSDADEATPFVEVAEHNRLAKEAIARRAVSMVADGDVVIIDIGTTTRLLARHLRGRAVTVVTTSLTVLDELRPDPATEVILVGGVLRRAYHSLVGVIAEDVLSKLSADLAFLGTSGVNARGQVLDTSLVEVPVKRAMLRAAGRHVLLADHDKFPGAGALEVTGVEGFDAVVTDHQTGQEALEMLADRQVEVVVA
>NZ_CP013126.1|WP_015069491.1|227650_228748_+|PfkB-domain-containing-protein
MTQQDGNPSPHRPADVVLTGTVFWDLVMTGLPRIPGNGEEIRVQRMATAPGGVANLAIASARLGLRTALVTEMGRDMAGRFCWSTLEQEGVDLSASRIHEGWTTPVTVSMTHDGDRRMVTHQTPPPAGPTTDDGLATVPSPRAALIDLDQLHSADQTRSSGRLSDWVRHAHDAGTVVLADIGFDETGRWDPAVLDGLRHCDLFTPNATEAMGFTRTATARDAARALAARVPLVVVTDGLDGAWAVDSSAGTEIHAAAVPVPPDEVVDATGAGDVFDAALVWGTLAGWPLDRRLDLACLCSSLAVRGLTGSMGAPGWAEVGAWWRGIAGSAADPDLADRFAFLDECELDAPPRLPAPTSIGWNLPA
>NZ_CP013126.1|WP_015069490.1|228812_230162_+|extracellular-solute-binding-protein
MKRRDFLTMSAGLALLAGCAPGSGQSTSTGSATAPSAVSTDPAKIGRATLTVWDQEVRGGGNSELTKLIASFQKAYPDITIKRVSRSFDDLTKTLRLALSGNDAPDVIQANNTRSQMGEFVKAKYIIPLDSYATAYKWNDRYSESLRATASYSTDAKTFGSGTLYGLPQMGEVVAIYTNKSKLSSLGIKSPSTWEEFEAALARAKSSGEVPLAFGNLDKWPAIHILGVLQGQYEQPAAARKLGYGDAGASWTSEGNRKALTKFQEWVTKGYFTPGFNGLGYDPAWQQFSKGKGVFLIAGTWLAADLTTAMKDNVGFILPPPAKAGGVSYTTGATSLPFAITGKCKNPDAAAAFINHITSSEAMKVIAETGNLPVVESDKQKAPDALSKQLFDAFGTTTKNDALLPYLDWATPTMSDTLGAALQDLLAKRASVDQTAQTIQKDYGDFTSK
>NZ_CP013126.1|WP_138575432.1|230291_231134_+|sugar-ABC-transporter-permease
MAWLYILPGFLIYGLFLLYPLIRSVQISLYDWDGLTLGTWAGLGNYAKVFTDVSLRGAFGHALVLMVFFAVLPLVIGLVLAAAINHGKVRGLSFFRTVIFLPQVVAMVAIGVAWRHIYEPDGPLNQALQGIGLGALARAWLGDYTWSLPAVGFVGTWFEIGLVTILMLAGMSRIGRDQYEAARLDGAGPVREFFAITLPSVRGETAVALTMTVIAALKTFDLVYIMTKGGPGNQTSVPSYEVYHRAFELGNVGTAAAIGVVLTALIFVISVGIQRLGRQD
>NZ_CP013126.1|WP_015069488.1|231133_231931_+|carbohydrate-ABC-transporter-permease
MRTSRSETLVNYLILGIFAVFALAPLATLLSSALGHDTGAPGGVANFATAWTQGHFGRSMVTSIVVSVIVVVVATTASIMTGYAFGTMRFRGSTPVFYLFLLGMMMPSEAIVVPLYFDLRSLHMTDTIWAIVLPQTAQSIAFGTFWLRAYFRTSSRELVEAARLDGLNSWQTLWRIVAPVGRPSILTLVVLEFMWTWNEFLIPLVMASSESLRTAPLGLAFFQGQYTQGFTLLAAGAVIVALPVVIAYVFLQRHFIAGMTEGAVK
>NZ_CP013126.1|WP_015069487.1|232048_234646_-|ATP-dependent-chaperone-ClpB
MDTNLTTMSRDAVSAASRHALAHGNPSVEPSHLLHALFTIPDNTVGPLVKGLGAEPEQVDRVATEAMRKLPSSSGASVSQPQLSGSFARVIADAQNRAQQLGDSFVATEHLLISLTTVPSDVQPGLAALGLRADALTRAFNEARGDRRVTSEESEGGESALAKYSVDLTERARSGKLDPVIGRDAEIRRVVQVLARRTKNNPVLIGEPGVGKTAVVEGLAQRVVAGDVPDSLKGRRVVSLDLSSMVAGAKYRGEFEERLKAVLNEIKEAEGQIITFIDELHTVVGAGATGEGSMDAGNMLKPMLARGELRMIGATTLDEYREHIEKDPAFERRFQQVFVGEPSVEDTIAILRGLRERYEAHHKVRITDGALVAAASLSNRYITARQLPDKAIDLIDEAASRLRMEIDSSPEEIDTLRREVDRMKMEIFAVEKEEDPASRQRLARLQGEMADKQERLRGLESRWQAEKAGLNRVGELKTQIDGLRTTADKFQREGDFGKASEILYGQIPGLEKEMEAAAQAEEETPRMVSEEVGTTDIAEVVSAWTGIPVGRMMQGEQEKLLKMESRIHDRLIGQDKAVATVADAVRRSRAGISDPNRPTGSFLFLGPTGVGKTELAKSLAEFLFDDESSMVRIDMSEYMEKHSVSRLVGAPPGYVGYEEGGQLTEAVRRRPYSVILLDEVEKAHRDVFNILLQVLDDGRLTDGQGRTVDFRNTILILTSNLGSQFLSDQSLDETARREAVMGAVHAAFRPEFLNRLDDIVLFDPLTTADLSRIVDTNLAKLNSRLAERQITVELTQAAKDWLAMTGYDPVYGARPLRRLIQTTVEDKLARRMLSGQTVEGDAVTFDVSSDSDGLEIVTGDPAPVA
>NZ_CP013126.1|WP_015069486.1|234780_236163_-|ABC-transporter-substrate-binding-protein
MLHDISGRALSRRSLLGLAGIGVSAAALTACSGPSTTATAASASSSASGGPSFTGVTPAKSISFWSNHPGGSQAVTQSIIDAFKKQSGITVKLVTAGSSYEDVAQKFQSAQAGGQLPDLVVLSDVWWFRYFMQDSIIPLGNVLKAAGLSLSDYRPGLVADYQYKGEQWAVPWARSTPLFYYNKSHFKAAGLPDRAPATWAEFAAWGPRLMAVKAATKAKYAYEVPALADYAGWTLQNILWGYGGGWSKKDSFDITCDSAASIAALQVVADSVRRSKWAGVASTAAIDDLAAGACSSTIESTGSLVGVQKAVGSRFEVGVGNLPGGPAATRPVCPTGGCGVGIPKGIDKSRQLAAAKFIAFLTNPQNTVTFSGATGYLPVRTSADTSGLLAKNPLIGTAISQLDVIRTQDWARVFMPGADQEMAKSVAAIVSQGAEVSTTMKALRTTLEGIYTSQVKPHLG
>NZ_CP013126.1|WP_051281536.1|236195_237101_-|carbohydrate-ABC-transporter-permease
MSLVLNRTRVRIPKAAGVPADESIVGPDPWTRRLLGGYLPLIAACLLIVAPLLWMVLGSFKTSGEVVTQDLVLWPHHPSFDAYTSASSKVNFPRLFANSVLVTAVGAFIKLVLAITSGYAFSFLRFPERRIIFTLILVALMVPSQVSMVPNYITIAGLGGVNTYWGIILPGLGTAFGTFLLRQSFMALPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDSRMTLPVGLTLLKNIEGDPSAYPVLMAGAVVVIAPVLLIFLFLQRHIVAGLTQGAVK

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Crispr_ID: NZ_CP013126_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013126_2

371517-371604

Orphan

Consensus_repeat	Method
GGGTCTGTGACCGAGCCCAGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013126_2

>merge|NZ_CP013126|2|371517-371604|CRISPRCasFinder
GGGTCTGTGACCGAGCCCAGCCCCTCCACGCTCGCGCAGGCGCTCGCTTCCTCCCCGAACAGGTTGGGTCTGTGACCGAGCCCGGCCC

>NZ_CP013126|2|2|371517-371604|CRISPRCasFinder
GGGTCTGTGACCGAGCCCAGCCC	CTCCACGCTCGCGCAGGCGCTCGCTTCCTCCCCGAACAGGTT
GGGTCTGTGACCGAGCCCGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013126.1\|WP_028701396.1\|359548_360367_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223635
NZ_CP013126.1\|WP_015069348.1\|382170_383544_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP013126.1\|WP_015069353.1\|377244_378618_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP013126.1\|WP_051281996.1\|376526_377255_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225140
NZ_CP013126.1\|WP_015069364.1\|365600_366380_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP013126.1\|WP_015069362.1\|367157_368990_+\|beta-galactosidase	unknown	unknown	gnl\|CDD\|366567
NZ_CP013126.1\|WP_015069367.1\|360366_361170_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|369792
NZ_CP013126.1\|WP_015069361.1\|369134_370358_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NZ_CP013126.1\|WP_015069356.1\|375214_375571_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_015069359.1\|370767_371388_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_CP013126.1\|WP_015069358.1\|371631_371961_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NZ_CP013126.1\|WP_015069360.1\|370394_370709_-\|thiamine-binding-protein	unknown	unknown	gnl\|CDD\|376658
NZ_CP013126.1\|WP_081583319.1\|381239_382010_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375436
NZ_CP013126.1\|WP_028701395.1\|355818_359148_-\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235681
NZ_CP013126.1\|WP_060539034.1\|378648_379182_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226089
NZ_CP013126.1\|WP_060539035.1\|379178_380264_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226089
NZ_CP013126.1\|WP_015069363.1\|366376_367003_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP013126.1\|WP_015069351.1\|380260_381247_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP013126.1\|WP_154662072.1\|361326_362985_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NZ_CP013126.1\|WP_028701399.1\|372060_374982_-\|DNA-polymerase-III-subunit-gamma-and-tau	unknown	unknown	gnl\|CDD\|236090

Protein	Function_ID	Function_description	E-value
NZ_CP013126.1\|WP_028701396.1\|359548_360367_-\|HAD-family-phosphatase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.06059e-52
NZ_CP013126.1\|WP_015069348.1\|382170_383544_+\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.41906e-37
NZ_CP013126.1\|WP_015069353.1\|377244_378618_+\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.40872e-39
NZ_CP013126.1\|WP_051281996.1\|376526_377255_+\|hypothetical-protein	gnl\|CDD\|225140	COG2231, COG2231, Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair].	2.9251e-53
NZ_CP013126.1\|WP_015069364.1\|365600_366380_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.08732e-104
NZ_CP013126.1\|WP_015069362.1\|367157_368990_+\|beta-galactosidase	gnl\|CDD\|366567	pfam01301, Glyco_hydro_35, Glycosyl hydrolases family 35.	2.12659e-128
NZ_CP013126.1\|WP_015069367.1\|360366_361170_-\|HAD-family-phosphatase	gnl\|CDD\|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	7.7484e-43
NZ_CP013126.1\|WP_015069361.1\|369134_370358_+\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.08522e-58
NZ_CP013126.1\|WP_015069359.1\|370767_371388_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	2.79453e-119
NZ_CP013126.1\|WP_015069358.1\|371631_371961_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	1.47163e-30
NZ_CP013126.1\|WP_015069360.1\|370394_370709_-\|thiamine-binding-protein	gnl\|CDD\|376658	pfam01910, Thiamine_BP, Thiamine-binding protein. The crystal structure of two of these members shows that this domain has a ferredoxin like fold and is likely to exists as at least homodimers. Sulphate ions are are located at the dimer interfaces, which are thought to confer additional stability. Although the function of this domain remains to be identified, its structure suggests a role in protein-protein interactions possibly regulated by the binding of small-molecule ligands. Solution of the structure of the hyperthermophilic anaerobic Thermotoga maritima sequence, UniProtKB:Q9WYV6, shows that this has a beta-alpha-beta-beta-alpha-beta ferredoxin-like fold and assembles as a homotetramer. It was possible to identify a pocket in each monmer that bound an unidentified ligand. It was also found that it bound charged thiamine though not hydroxymethyl pyrimidine. It is proposed that it is transporting charged thiamine around the cytoplasm. Under oxidative conditions this bacterium is under stress, and the transcriiptional unit within which this protein is expressed is up-regulated in these conditions, suggesting that the chelation of cytoplasmic thaimine is part of the response mechanism to such oxidatvie stress, which is mediated by this family.	2.91823e-31
NZ_CP013126.1\|WP_081583319.1\|381239_382010_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|375436	pfam17933, TetR_C_25, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in Rv1219c of Mycobacterium tuberculosis. Structural studies indicate that the helix alpha 10 of the C-terminal end of Rv1219c forms a long arm feature, a feature which is unique in Rv1219c compared to some other members of the TetR family. Furthermore, it has been shown that substrate binding occurs in the C-terminal regulatory domain of Rv1219c.	2.95487e-27
NZ_CP013126.1\|WP_028701395.1\|355818_359148_-\|isoleucine--tRNA-ligase	gnl\|CDD\|235681	PRK06039, ileS, isoleucyl-tRNA synthetase; Reviewed.	0
NZ_CP013126.1\|WP_060539034.1\|378648_379182_-\|hypothetical-protein	gnl\|CDD\|226089	COG3559, TnrB3, Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane].	5.7875e-22
NZ_CP013126.1\|WP_060539035.1\|379178_380264_-\|ABC-transporter-permease	gnl\|CDD\|226089	COG3559, TnrB3, Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane].	2.05966e-64
NZ_CP013126.1\|WP_015069363.1\|366376_367003_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.112e-16
NZ_CP013126.1\|WP_015069351.1\|380260_381247_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.15477e-78
NZ_CP013126.1\|WP_154662072.1\|361326_362985_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	1.7195e-42
NZ_CP013126.1\|WP_028701399.1\|372060_374982_-\|DNA-polymerase-III-subunit-gamma-and-tau	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0

>NZ_CP013126.1|WP_015069359.1|370767_371388_-|recombination-protein-RecR
MYDGPLQDLIDALSRLPGIGPKGAQRIAFHILDASQEEVDALADTLREVKEKAKFCSVCFNVSADETCRYCRDSRRDQSVICVVEESKDVIAVERTREFRGLYHVLGGAISPLDGKGPADLHIRELCTRLADGVVTEVILATNPNLEGEATASYLSRLLTPMGVKVSRLASGLPVGGDLEYADEVTLGRAFEGRRYVSAEPDARTA
>NZ_CP013126.1|WP_015069360.1|370394_370709_-|thiamine-binding-protein
MIAAFSLVPSGGRASREDGGVAEAVAAAVRVIRESGLPNRTNSMFTEIEGSWDECMDVVKKATEAVAEYGTRVSLVLKADIRPGRTGEMTGKLERLEAEISKQA
>NZ_CP013126.1|WP_015069361.1|369134_370358_+|MFS-transporter
MTSAASATRFAPPRQAVRARMGTLMLFATNGLTFASLIPRYPEIKADLGASQTLWGLAVGIGPIGGLALGLATARLMSRFGSRNVAAWPQILSTAGLLLMANAPHVGWVFVAMIAMSAFDAVTDTAMNYQALRVQEMYKRSIINTFHGWWSVGAVLGGFIGSAMAQWRVDINLQASLTMVVLALVCALSWSLMLPGRDTGTDRSTSDGDQRRARVPATTWLHIIGLGLLGALAGGIEIGGSTWAPLYMDAQFNSTPFIAGMGFTILMVAETAGRLIGDLIVNRFGQAFAVAQGSVICLVGMAVAIAWPTTASTLIGFAAAGWGVATIIPLAMNVADSLPGVRSGAGLTIATWVMRLGFMLFPIGIGALGDAVALRWAMICLPAGALVMLALVPLVGAGRRRRAPEAV
>NZ_CP013126.1|WP_015069362.1|367157_368990_+|beta-galactosidase
MAENAALIRADGALLRVTDDGALTRAGAPHRIMSGSMHYFRVHPGQWRDRLRRLVDMGLNTLDTYVAWNFHQPQEGRPATFDGWCDVERFIGMAGEEGLDVIVRPGPYICAEWSNGGLPSWLTRRTASENGVGRRPLVPRSSDPGFTRRVARWFDDLIPRIAALQACHGGPVVAVQVENEYGSYGDDAAYLTWLRTALVERGVTELLFTADGPTELMLDGGTLDGTLAAVTLGSGARAARELQQSRRPGEPFLAAEFWDGWFDHWGEKHHVRSADSATAALSEILDAGSVSIYMAHGGTNFGLWAGSNEDNGKIQPTVTSYDSDAPIAEDGRLTPKFHAFRELLGATGPLLSTEPRFLPETSVPLTPAAGLLPGLMANGIPTPRTPAPASFEQLRLDAGISVHRARPVLPHGPVTLRITDLADRAVVFVDGERVGALEGPGQITVEGHGRRVDLLLIVEAYGRINYGPLLGAPKGLLGPVMVERRMIHGWWNRAVPLQDWGDLELARAMAAGDDVNNEGTGFATASWSVEEPADTHLMLPGSGRGYCWINGFLLGRYDERGPQCSLYCPAPLLHPGSNTVTVLETEHLGDSVEMRQHPDLGPTEEYIEQF
>NZ_CP013126.1|WP_015069363.1|366376_367003_-|PadR-family-transcriptional-regulator
MSIRFAILALLDERASYGYEIKAEFDRRTNRTWPLNIGQVYTTLDRLERDQLVSRGSENAEGRVMYEITPGGSRAVSDWFASVIPDYPQRDELAIKIAMAATRPGCDVGAIIQNQRRESMRALQNHHQALRGIDEEDLAGELVIQSLIYSSEAQIRWLDHCETAALRASRSASRGAGGPGGAGTPRATGADAAAPAGKRATRITRDAR
>NZ_CP013126.1|WP_015069364.1|365600_366380_-|ABC-transporter-ATP-binding-protein
MTAPVRAADRPEAPAGRTVLSLDHVSRTFEAGSQPVHALSDVCIGVDPGAFISVMGPSGSGKSTLLALAGGLDQPTAGAVSVCGQPLAGLSRDDLARIRRRQLGFVFQDFNLVSTLTALENVALPLELDGVGARQARTVAEEALDRVGLPELGDRFIEEMSGGQQQRVAIGRAIVGDRRLLLADEPTGALDSATGDEIMALIRKLADEGVAVVLVTHEARHAAWADRVVFLRDGRLVDESESESDPMSLLAEGPRRGSW
>NZ_CP013126.1|WP_154662072.1|361326_362985_+|threonine/serine-exporter-family-protein
MSGTQGGTPSRSRRLWRVPLERYLRDARPLPPSRDLESVCEDEMAAAQAREVFDLIMRVTVVAVSVGASSAEAIAMGLRIADAYGINVHIDITNSSVIVTQHRSLDDDPITALRVVRTRTADYQRLGRLEQLVADVSARRIEPAPARERLNDLMTAPRLYKKWFVTVNMGVMGAAMAALYGASVLDVVIAFAAICLVDIAVQGLARRRVASFFVQAVGGAIPTAVALVLMLLRTATGMRLDLSPSLVVAAGMISLLAGTGAVAAAQDALDGYYVTSAGRFLEVLLQTGGIIFGVMTTLWIGLKLGVPGYISPQLVWTSAPWVQIVASVIASIAFGATAHSGPRTLGVCGILGGLGWSEYLVGMWLTDSMVIASGIGAVAIGLVSAAAAKRWRVPQVALVTISVVPLMPGMMLYRGLYMTMAGQLGIPAPGTGVTVLAQSLLIGVALAAGSSLGALAARPFAIPSDHRTRRAVMASWFRGSAVPRDWVPRRHRRRTPRPVPTAEPDGPEATASVPAPQHRTGGGDERPHGEAREGRDAQCQSDQVSPGDREGH
>NZ_CP013126.1|WP_015069367.1|360366_361170_-|HAD-family-phosphatase
MLIATDLDGTLVRSDNTISPRALKAIAAAEEAGVPVVPVTGRQFGGLRDILGAFSRYALVNNGSMGVDLADGQRTMFCETTPAATVAAFVDAVREYSPKASFAAVREEGRVFAHTDGYLELTRPDELIKDPAEYRRVEVAEIGTQDCLKLMVRSAEMPLEEFVARTLGLGVAGAHTSWSGFPMVEMCADGLTKATGLDRLTRLLGMTRADVVALGDGGNDVEMLGWAGRSFAMADGQQVARDAATDVAPPADEDGFAQVVESLLETL
>NZ_CP013126.1|WP_028701396.1|359548_360367_-|HAD-family-phosphatase
MFIATDLDGTLLTPSGTISARSAAAIAAAEEAGVPVVPVTARQLYGLDDLRSRLGRWALCSNGAVCWDLHAETVLFHLETSAEVASTFARELLAVEPRTRFASIQRDGAFFASQAGYADLCVFTDHHRDPADMPRLGIEEVVGAPTLKLVARHPSLSVQELAAVARRLPSASAVHITSSGAGMLEISAAGVTKSAGLQVFADHLGMTGADAVAFGDGENDVEMLRWAGRSWAVANAVPAALEAAGKIAGSNAEDGVAQVIEELLEQRNATVA
>NZ_CP013126.1|WP_028701395.1|355818_359148_-|isoleucine--tRNA-ligase
MSDATSAQQSPGTSSPGTYNSVPPQIDLPAMEHEIIDLWHENHTFEKSLEQTADGQPWTFFEGPPTANGQPGTHHIEARVFKDVFPRFKSMQGYRVDRKAGWDCHGLPVELAVERELGFSGKPDIEKYGVEPFNAKCRESVTRHVDAFSELTERMGYWVNMDEAYWTMHPQYVESVWWGLKQVFNKGLLGEDYRVAPYCPRCGTTLSDHELAQGYQDDRDPSIYVQFPITSGPLAGRAKLLVWTTTPWTLVSNTAVAVHPDVTYVVAHRNPAPQTDADSETTAEADPGEDLVIAEPLFDAVLGEEWSRTGESFQGTEMEFWTYERPYDWVKWPATEHRTLDGRETPADANFVILADYVTVEDGTGLVHQAPAFGADDFATCRAYGLPMVNPVRPDGTFEADIPMVGGVFFKTADKPLCEDLEKRGILWRLEMHWHSYPHCWRCDTPLIYYAQPSWYIRTTQIKDQLLAQNEATTWYPETIKHGRYGDWLENNIDWAVSRTRYWGTPLPLWRNDDDRDDVICVGSLKELSQYVGRDLSGLDPHRPFIDEITFERNGHIYHRVPEVADAWLDSGSMPFAQWGYPHVPGSEEKFLAHYPADFICEAIDQTRGWFYTLMAVGTLVFDQSSYKNVLCLGHILAADGRKMSKHLGNILLPIPLMDKHGADAVRWFMAADGSPWSARRVGDDTIQETVRKILLTYWNTVSFHALYARANDWSPAAATAGEGDCAQTGAPRGLGGVVPPALEDRHVLDRWLTSATNVLVRDVTASLNDFNTQHAGALIQEFIDELSNWYVRRSRRRFWDGDPSALWTLHETLNVLTRLMAPMVPFITERVWQDLFVPTDPNAPESVHLASWPVADESVIDEDLDHAMDLARRVVELGRGARAEAKMKVRQPLSRALIAGSALAKLDEPLQAEIRAELNIGALEAFGSSGDLVDHSAKGNFRSLGKRFGKATPKVAAAVAACDASMLATELAAGHEVTLDVPEAEGGKATIGADDVIISERPREGWSVVNEQGETVALDLEITPELARAGLAREAVRFIQDTRKHVGLEVSDRISLTWHADGDLAEAIRDHAGEIADEVLATSMGEGTPDDAWATEPDLGLSISVVKA
>NZ_CP013126.1|WP_015069358.1|371631_371961_-|YbaB/EbfC-family-nucleoid-associated-protein
MTTPEGGFDMSGFDMNGLLAQAQAMQAQLAQAQQELAAATFEGSAGGGLVTATVSGSGELQALVIKPEAVDPEDTETLSDLIVAAVRDASAKAAAKQASLVPKIPGLGM
>NZ_CP013126.1|WP_028701399.1|372060_374982_-|DNA-polymerase-III-subunit-gamma-and-tau
MADEPSDDDRLDEYVQDGPDLFGGEPEPAEPGAGAEPTPADDVEEEPDDGPVDAFSGPETPLEPEGLDSEEDVDPDDLIVPEVEEPEPEPEDEPDAGPVDVPSDDVPEPPLALYRRYRPETFDEVIGQEHVTEPLKRAILNNRVNHAYLFSGPRGCGKTTSARILARALNCEKGPTPTPCGVCQSCRDLGRGGPGSIDVIEIDAASHGGVDDARDLRERAFFAPVASRYKIYIIDEAHMVTTQGFNAMLKLVEEPPPHVKFIFATTEPEKVIGTIRSRTHHYPFRLVPPKTLVTYLEQICQQEGIAVDHAVLPLVVRAGGGSVRDSLSVLDQLLGGAQADGVSYEQAAALLGYTPDALLDQIVDAFAAGDAHEVFATIDKVIEVGQDPRRFAEDLLRRMRDLVILAAVPDACTSGLIDVSPEQAGRLSHQVAGLGSGELTRAAEVLATGLTQMRGTTAPRLHLELMCSRILLPGADAGDRGYSARLERLERRMGMGDGVAGEMPAAPVPVTPVQSTGSAAPVASAETSQPSRTAGGETPQSRWQESPRQASPQPPQELDTSGAGAPPPRSSGASATSPQQPSQPRRRPRPSSRDYAPGGQGPEARRDQPQARPQENRPEQPRQDRSRQESPSSPRPDAGPRPGEQASGPAPSGQGQVDIAMVRRAWPQVLDVVRGRRKVAWMVLSQYAQVVEVHGRSATIAFANPGARQMFESGPDQATLHDAVVEVLGVDLTFTPVLGGGQGPAGPAPSGPSQPEPYSAGPGGGSGPGYGSEPGGPQEAPPDPSEPGRDQTDRDRAVDGPVGVVVDPAGGVPVPARDAADRESVAARPDSPVPAPDSTPISDGVRASAPSPAGVPMPSSGPSPSSGPSPASGPSPASASTPPERAAGDPAGGKDAGAIDDAAHHVMTHRWSARAKENIRAMSHRVDEAPPEEPPEEADWTDSEIVEAPQQSPAQLIMAELGGVVIDDPLAEQ
>NZ_CP013126.1|WP_015069356.1|375214_375571_-|hypothetical-protein
MTERRIITTNRAGVIWSGITWVCVLLFLPAGLASMAMQTLLPANLGYPQLDAPSGVPVWLNRTVLVLDILVFVIPPLVVTLANKKAKRLGHRVKGVVAGSWAVAGLVAAIALMLWFFG
>NZ_CP013126.1|WP_051281996.1|376526_377255_+|hypothetical-protein
MPTTLDLRDLPAALRAHLGPRTAWWTVRSPFEILVGCVLVQNTNWRNVEGSLAGLRDASVDSPADLLNTTTPELTALIRSSGFQTSKERALRGLCGWWATRLGGTGPAIKAPVEASALLATSALLPETPTPQLRAELLGLRGIGPETADVIMLYLLGRGVFVSDTYARRLLTRLGLAVPRSYNALARLVTRQVDLDLAGWQEFHGLIDDYGKQYCTGDAAWERGPLAGHRLAPKDGGAVHAR
>NZ_CP013126.1|WP_015069353.1|377244_378618_+|APC-family-permease
MPVDRLTAPPRRDHRPDRRGDGGLRRSLTLPTLIVYGLLFIGPTSPMGTFGVLDARSHGAIGLVFIIATLAVAFTAWSYARMSRAVPLAGSVFAYASAGLGRRPGFIAGWMLGLDYLFMPSMMSLILGIAAHHLVPSVPAWVFTAAGIVLMTGLNLAGIRTTTTVSFIILGVEIVMLAVFVVAAVVVLATHGPQRGWLSPLTGVGPFDPAGVIGAVSIAVLSFLGFDGIASFAEETTGSSRQVSRALVVCLVLAGALFVVQTYLAALLSPRTPGYLAAHQGEQGTDFYQLLDSQIGTWLGTTVTVVKAIGPVFSAMVAQAAASRLMYGMARDGALPRPLARIDRRTRTPRNAVLVTAVLTLSISVSAAIRPDGLDLLSSLVTVGALVGFLFLHAAVIGYFVCGRRTSHRAAHIVIPVIGGLIIATVLALAAHPALVVAGIWLAIGLAALAVRERTAG
>NZ_CP013126.1|WP_060539034.1|378648_379182_-|hypothetical-protein
MTALAVHLVLRLREEESAGRIEHQIAMGAGRIGVMGGWLAVSAVGVTLALLASAVGLGIGTASALDDRAWLWRLIGATLGYLPAVLAVLGLAVALVGWAPRAAKAAWILVGWIAVVVFFEDLLGIPDAVADISPVALTPTAPAEDASVMVLICLTAAAAVLSGIGLWGMRRRDLTGA
>NZ_CP013126.1|WP_060539035.1|379178_380264_-|ABC-transporter-permease
MTPLTGTLRLLGWGLRRDRLRIGMWCLGVGLTAGATVPAVRDAYPDAAARIARAEISRMPGTVVMTGPFFGAGPSGSAHDPGVGAVVVSEIGMFLLVAVAIMSILAAVSHTRGDEEAGRTELVRALPTGRAAPASAAMLLVVLMNALVAAVVAGCLVATGLDLAGSLAFGASCLVTGLAFGALALCAAQLAEHSRSAGGLAMAVLGALFLARAVGDVDDPDGGSWLSWLSPIAWAQQIRAFADLRWWPLGLGLGLAVLALVVAWLLAGRRDLGEGLLPARRGRASAPAGLVSPAGMALRLLRPSIIAWTIALLVLGVVFGSLAGAIEDLVAETPEIATWLGARGRCWIRSAVSSPPIWPPA
>NZ_CP013126.1|WP_015069351.1|380260_381247_-|ABC-transporter-ATP-binding-protein
MNDAPIDCRGLEKSFGRTRALNGFDLRVEPGEIAGFLGPNGAGKSTTIRILLGVLRADGGTARVLGADPWADAVALHRRMAYVPGDVSLWPGISGGEIIDYLVGLRSTAYRRSDQYRRRRRDLLERFQLDPTKKAGTYSKGNRQKVALVAALSCDADLYLFDEPTSGLDPLMEALFTAELARLRDEGRTVLLSSHILGEVENACDTVTIIRDGRAAESGRLDELRHLRRAGVEAVLSGEAADRLGALDGVHDVSRDGERMAFTVDDAAMTQVLGTLADVDAREVSIQPVRLERLFLDHYESSSDRDIPGEDGEGRHAEGKTDARGTRR
>NZ_CP013126.1|WP_081583319.1|381239_382010_-|TetR/AcrR-family-transcriptional-regulator
MDSTNESGDRAPSGPGRKAGGTRGGARAQVAEETRARILDAAFGVFAEQGFAAPLRAVADRAGVSAALIVHYFGSHDGLRRACDERFDELTTELKTDVLDPVAGPAEARRQSDDIAHYAPMIGYLIRVLRAGDAASIRFVDRMSEAAEQYLARGVEAGMIRPTGDEPARARTLVAMSLGAVMLGFPTLDGRIDLETLPERLDEYRGRSLVPMLEIATYGYLTDSRILDALTHDDTTDHEPTDDDITHHNAEADGHE
>NZ_CP013126.1|WP_015069348.1|382170_383544_+|APC-family-permease
MAKDNAAAQAPETREDSGLRRSLTLRDLIVYGLLFIGPTAPMGTFGVLDARSGGAIGLVFVVATLAMAFTAWSYARMSRAVPLAGSVFAYASAGLGRRPGFIAGWMIGLDYLFIPSMASLFTGIAAHQLIPAVPVWVFTLIGILIITGLNLAGVKTAAIVGFVMLAIEVAVLAVFVVAAAVVLARHGAQRPWLSPLTGLDGFDLAGILGAVSVAVLAFLGFDAIASFAEETTGSNRQVSRALQFCLALAGALFVVQTYLGALLSPLTPAYLNAHQGEQGTAFYQLLDTQIGTWFGTTVTLIKAVGPVFSALVAQAAVSRLMFGMARDGALPKALATVDPRTRTPRTAVLVSAVFTILIAIAAAVREDGLEVLSSMVTVGALVGFLFLHAAVIGYYVRGRRTEQRTRHIVVPVVGAVIIAIVLALAAHLALAIAAVWLVIGVVVLVIRESRRKEPERS

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Crispr_ID: NZ_CP013126_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013126_3

511011-511149

Orphan

Consensus_repeat	Method
CACCCGCAACGCGTGGCCACGGGTGCCGACCCACCTCCCACGGACCCGACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013126_3

>merge|NZ_CP013126|3|511011-511149|CRISPRCasFinder
CACCCGCAACGCGTGGCCACGGGTGCCGACCCACCTCCCACGGACCCGACCGTCGGGGAGGCAGCCCCCAAGCACGGCCACGGACTTCACCCGCAACGCGTGGCCACGGGTGCCGACCCGCCTCCCACGGACCCGACCG

>NZ_CP013126|3|3|511011-511149|CRISPRCasFinder
CACCCGCAACGCGTGGCCACGGGTGCCGACCCACCTCCCACGGACCCGACCG	TCGGGGAGGCAGCCCCCAAGCACGGCCACGGACTT
CACCCGCAACGCGTGGCCACGGGTGCCGACCCGCCTCCCACGGACCCGACCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013126.1\|WP_081685342.1\|521999_524237_+\|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|380193
NZ_CP013126.1\|WP_028700505.1\|505163_505481_-\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NZ_CP013126.1\|WP_028700514.1\|517252_518083_-\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NZ_CP013126.1\|WP_028700512.1\|515017_515632_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239646
NZ_CP013126.1\|WP_036936405.1\|507720_508716_+\|zinc-binding-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|176214
NZ_CP013126.1\|WP_028700515.1\|518213_518459_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_028700507.1\|506571_507087_-\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|223463
NZ_CP013126.1\|WP_028700510.1\|509713_510331_+\|DNA-3-methyladenine-glycosylase	unknown	unknown	gnl\|CDD\|234840
NZ_CP013126.1\|WP_028700509.1\|508739_509060_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_051281618.1\|507101_507611_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP013126.1\|WP_028700513.1\|515762_517112_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP013126.1\|WP_015069255.1\|511195_512371_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340825
NZ_CP013126.1\|WP_028700506.1\|505522_506533_-\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP013126.1\|WP_028700517.1\|519009_520143_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_076692606.1\|512474_515021_-\|ATP-dependent-helicase-HrpB	unknown	unknown	gnl\|CDD\|273901
NZ_CP013126.1\|WP_036936328.1\|502845_504675_+\|Na+/H+-antiporter-NhaA	unknown	unknown	gnl\|CDD\|377746
NZ_CP013126.1\|WP_154662022.1\|518443_518908_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_076692607.1\|509035_509665_-\|RNA-2',3'-cyclic-phosphodiesterase	unknown	unknown	gnl\|CDD\|274058
NZ_CP013126.1\|WP_015069256.1\|510362_510899_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_157756364.1\|520523_521948_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369025

Protein	Function_ID	Function_description	E-value
NZ_CP013126.1\|WP_081685342.1\|521999_524237_+\|leucine-rich-repeat-domain-containing-protein	gnl\|CDD\|380193	NF033189, internalin_A, class 1 internalin InlA. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin A (InlA), a class 1 (LPXTG-type) internalin.	7.88021e-37
NZ_CP013126.1\|WP_028700505.1\|505163_505481_-\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	4.86712e-44
NZ_CP013126.1\|WP_028700514.1\|517252_518083_-\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	1.15542e-74
NZ_CP013126.1\|WP_028700512.1\|515017_515632_-\|NUDIX-domain-containing-protein	gnl\|CDD\|239646	cd03674, Nudix_Hydrolase_1, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, U=I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.60953e-27
NZ_CP013126.1\|WP_036936405.1\|507720_508716_+\|zinc-binding-alcohol-dehydrogenase-family-protein	gnl\|CDD\|176214	cd08252, AL_MDR, Arginate lyase and other MDR family members. This group contains a structure identified as an arginate lyase. Other members are identified quinone reductases, alginate lyases, and other proteins related to the zinc-dependent dehydrogenases/reductases. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.66514e-157
NZ_CP013126.1\|WP_028700510.1\|509713_510331_+\|DNA-3-methyladenine-glycosylase	gnl\|CDD\|234840	PRK00802, PRK00802, DNA-3-methyladenine glycosylase.	2.12282e-84
NZ_CP013126.1\|WP_051281618.1\|507101_507611_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.07514e-20
NZ_CP013126.1\|WP_015069255.1\|511195_512371_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	1.59766e-77
NZ_CP013126.1\|WP_028700513.1\|515762_517112_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	5.45347e-117
NZ_CP013126.1\|WP_028700506.1\|505522_506533_-\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	2.62337e-146
NZ_CP013126.1\|WP_076692606.1\|512474_515021_-\|ATP-dependent-helicase-HrpB	gnl\|CDD\|273901	TIGR01970, ATP-dependent_RNA_helicase_HrpB, ATP-dependent helicase HrpB. This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity].	9.58995e-178
NZ_CP013126.1\|WP_036936328.1\|502845_504675_+\|Na+/H+-antiporter-NhaA	gnl\|CDD\|377746	pfam06965, Na_H_antiport_1, Na+/H+ antiporter 1. This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyze the exchange of H+ for Na+ in a manner that is highly dependent on the pH.	1.07282e-149
NZ_CP013126.1\|WP_076692607.1\|509035_509665_-\|RNA-2',3'-cyclic-phosphodiesterase	gnl\|CDD\|274058	TIGR02258, UPF0097_protein_AF_2157, 2'-5' RNA ligase. This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing].	4.54527e-24
NZ_CP013126.1\|WP_028700507.1\|506571_507087_-\|glutathione-peroxidase	gnl\|CDD\|223463	COG0386, BtuE, Glutathione peroxidase [Posttranslational modification, protein turnover, chaperones].	1.29832e-67
NZ_CP013126.1\|WP_157756364.1\|520523_521948_+\|hypothetical-protein	gnl\|CDD\|369025	pfam06662, C5-epim_C, D-glucuronyl C5-epimerase C-terminus. This family represents the C-terminus of D-glucuronyl C5-epimerase (EC:5.1.3.-). Glucuronyl C5-epimerases catalyze the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans.	1.19827e-06

>NZ_CP013126.1|WP_015069256.1|510362_510899_-|hypothetical-protein
MAHNAYKALSRVFSVVLPAAGAGLIAGGRFAHQYVADQLAGQRITMPGGKDLPTEEMKSALARYSGLPMTTGPQAEAYANHYIGAHLAAAAKGRTYEEISQEYMAASADPDRKDTQEAADLGQLKEMLFTGSSLRGMLLNAYGWWTVGSIASWAGVGATGLGAVLAVPGWARRRGHRA
>NZ_CP013126.1|WP_028700510.1|509713_510331_+|DNA-3-methyladenine-glycosylase
MIDLSQPALDVAPLLLGAVISHTVVLDDGSRAEVRIRLTEVEAYMGPDDPASHAFRGPTPRTAVMFGPPSHLYVYLSYGIHRCVNVVCSPDGRASAVLLRAGEVVSGEDLARRRRSGAARQVPDRRLACGPGNLGQALGAGLSDSGAVLWQSEGLCPPPEAATWRLEPPGSPTPCSRSRRVGISHNAEKLWRFTIPDDPTVSRPR
>NZ_CP013126.1|WP_076692607.1|509035_509665_-|RNA-2',3'-cyclic-phosphodiesterase
MGHRMYAALVPPAEVLEAVDATLERMAERTSPGDPRRLRWSRPGDAHITLVFMADVDDPDTLIDALAASLADQPPVAVGLAGAGAFPQPGRARILWLGVNDPADTLPALARRARSAARGAGGRPKSGRFSPHVTAARAHDADVTGEIEALSSFSTPMWVARSVTVFESHLPNPSRGGRRGGGGGVRHEPVAQIGLEGIPRRSQFRSPNQ
>NZ_CP013126.1|WP_028700509.1|508739_509060_+|hypothetical-protein
MKNCLKDPESLSTAPVVAAGLIGGWQVARATGVRPIGGVVLAAAGVLAGRSWWARKGAATAVGLSAAYLGAFGASHPLAKRIGAWPSVLTVTAAAAGAAYWFGDRN
>NZ_CP013126.1|WP_036936405.1|507720_508716_+|zinc-binding-alcohol-dehydrogenase-family-protein
MPAVAARALPITNPDSLVDVTVPVPTPGPNDLLVEVRAVSVNPIDIKLRNGAGTPEQPLILGFDAVGTVVAVGEAVEGFSVGDEVWHSGDRTRPGTYARFTLIDHRVAAMRPGTLAAAQAAALPLTAITASEALREHMRLGGNDSFLMIGGAGGVGSIAVQLAKLLTDGPVVATASHDESADWCLKLGADAVIDHRRPLPDQAAEIGVDGFDGVLSPHTVGKVAELAEVMAPFGHLVTIDGLPDFDILAFKPKSLTVTSESMFTRTQFHTPDIAEQGRILARVAELVDSGKVKTTMTTRLQGINAATLRKATEMVEQGHMIGKVVVEADAW
>NZ_CP013126.1|WP_051281618.1|507101_507611_-|MarR-family-transcriptional-regulator
MDEESTRIGTVTDLVEQTEPLEQMVCFAMYSATQATVQYYRDVLAPFGITYQQFLVLVELNLAGRQSPTHLADALHLDCSSVSGLLNRMERSGLVERIRDDKDRRAVSVAATDRSREIFSRLGFLGGCVSGAMGLEPDEMRALLKALHKVRDAMVSAPRPQPEPELVTA
>NZ_CP013126.1|WP_028700507.1|506571_507087_-|glutathione-peroxidase
MTTTQARQTVDLKDLPVTTLQGEHTTFGDIVGDRTALVVNVASRCGLSPQYEQLEALQKKYADRGFTVIGFPCRQFLGQELKSEKAIEEYCSTTWGVTFPMSARIKVNGSQTDPIYVQLKDFPRQEDGKDGRITWNFEKFVVSRDGHVTRFSPTTKPDEPQVINAIEKTLS
>NZ_CP013126.1|WP_028700506.1|505522_506533_-|thioredoxin-disulfide-reductase
MRDVIIIGSGPAGLTAAIYAARANLNPLLIASSVDVGGELMQTTEVENFPGFPDGIQGPDLMAAMQAQAEKFGTEVVYDDVAALDITGPVKKVTVGEGDTFEARTLIYATGSAYRKLGIDRETELSGRGISWCATCDGAFFRDRHVAVIGGGDSAMEEATFLSRFASKVTVIHRRDALRASAAMIERAKADPKIEFHWNSTVADFLGDQKVDGMRLRDTVTGDTEEMPIDGVFEAIGADPRTHLVHGVLDLTDAGTIAVDGRSSRTSVPGVFAAGDVIDPTYKQAATAAGSGVVAALDVQAYLATLDDAKTAQIDDAGNTEAAQSVVAEDTVPAAV
>NZ_CP013126.1|WP_028700505.1|505163_505481_-|thioredoxin
MSINVTDASFETDVLKSDKTVVVDFWATWCGPCRQVSPILDRIADEHSDKITLAKIDVDANPGIAQQYGITSIPAIFVFKDGELAKTTVGAKPKPVLERELAEFL
>NZ_CP013126.1|WP_036936328.1|502845_504675_+|Na+/H+-antiporter-NhaA
MDRNPENQNLQPLRRSMRIHRWLTNDIYAAIALALATVAALLWANIGSSYETFWHSHFGFILGSLDFELTLHEWVDEGIMAIFFFMVGLDVRRDLTLGELRSKRRAVLPIAAALGGLIVPAALFLIIEGGSEGAAAWGAVISTDTAFAVGMLAVVAPRNAPRLRVFLLALAVIDDIAALTVIAIFYTTDLNLIALGLATLGLIGVWLLERANVWRVGPYLVLALYTWGCFFASGVHATLAGVLIALLMPVYPPRRSDLQTASHVFDLFHQAPQPDMAKRAREALTFSVPMNQRLSSAIAPYVNYLVVPLFALANAGVVLSGDSLSTAFTSRLTWGLIAGLVVGKAIGITLASMLVLKLSPGSRLPGLDAPRIAGVGALSGMGFTISLLVAGMALDDPAATDQARVGIIAASLLALGLSWTIFRLSKKFNPLPPPSDAHLARDVDPEADHIRGPVDAPATLVVYASMNYTYRRQTAIAVSQTRAALGDQLRVVLRHAPVDDAAVTGALALEAAGSQGKFWEMHDEMLGIRGPLDSDLVREAAERIGLDVGRFERRIEKQTDRERVDDDGLDLAGFETSEKPVIYLNGERVANAANSLTLTLGARKALAGA
>NZ_CP013126.1|WP_015069255.1|511195_512371_-|glycosyltransferase-family-4-protein
MPNRRVTVINHYAFPPGSGGITRNFDMFSRLKNWTPHFFAANINHTSGQKMTVDDPRYTLVPIPEYQGNGVKRMLGWVAFAAGAGARALVRPADVIFASSPQILAPAAAMVVAKLRRKPFVVEIRDLWPDSLVSGGAVKEGSLLHKVLVGLERTIYANARRIVVVPTGWEDHFRELGIDVDKITVVPNGADLAEYDVPESKEELRSRYGISGFTAVFSGTHANYVGLDLIVDAAEKLPDVNFLLVGSGARKQWAVDEVASRGLANVTFHDQVPKSELVRILKACDVGLHTVTPQEVFNKGMSPNKLYDYMAAGLAVVSNAKVPLRDVIVDDEVGAVVEPYDLVEGISRVRDADEATMERWHAKARDLMADRFSLQASVDKLETVLDKSLYR
>NZ_CP013126.1|WP_076692606.1|512474_515021_-|ATP-dependent-helicase-HrpB
MIDLERIGAGLPVADHADRLRDALAGRRLVVQAPPGTGKTTFVPPLVATTVPGRVVVTQPRRIAARAAARRLASLTGTRAGALAAHTVRGESTLTPSTRVEFVTTGVLVQRLLRDPELIGVDAVILDEVHERHLDADLALAMVCELAELRDDLTVAAMSATLDAPMWAGLLGDGSTGEGGPAPVVEIPSVLHPLEVRWAPTPGSATDARGVRRAFIDHVVAQTALAFAAEEPAEREEGNGALVFMPGAREVDAVVAGLRGRDDLAGVDVMALYGRMDARAQDAALKPSDRPRIVVATSVAESSLTVPGVRLVIDSGLSREPRLDRGRQMTGLVTVRESQASATQRAGRAARLGPGVAVRCLRHEDWAGMAPEAPPEAEHADLVGPLLTLACWGTPRGEGMALPGALPPDRVAEAEEELRGLGAVDAEGRATPRGRDLAQIPADPRLARALTDARGIGSRAVAEVVAMLASDEPAADGDLVALLRALRSGRHPGSRSWKQQARRLESLVPRAAAAETTADVQVGTVVALAHPGWIARRRDNGGYLLVSGTGADLPRGSSLTGQEWLAVAETSRVAGRGSGALIRAAVPIDEGLALEAAAGYEVTEDRARWRAGRVSGRRVHRLGAVTLTSTPVKATRAAARRAVADALAEEGLGIDGHGVFTWSRGAIELRRRLGLLHRVIGGPWPAMDEDSLAARAEEWLGPELDALARGRGAGGASMASALRRLLPWPAAAHLDELVPESVVVPTGSHIRLEYPEVGSDLAPVLAVKLQECFGWTTGPTVCDGRVRVVLHLLSPARRPLAVTDDLASFWVNAYPQVRAENRGRYIKHPWPEDPLTAPPQRGTKKSGR
>NZ_CP013126.1|WP_028700512.1|515017_515632_-|NUDIX-domain-containing-protein
MAHLNTEPHGHDVTISAWIFRQVDGVTKALVHKHRKMGIWLQPGGHIEHTENPWQALVHEMREETGYEPEQYAVLQPLPRMRDGVHDVMHPVPAVMNTHSPYQGHFHSDLIMVLTTDEDPAHEPRPGESRAMAWLSPQEYASHEDAEPDAVAIMTMLAEKVVGHWYRTPATDWSLADAEPDPLTDRTPEQATAPDPEDDRETSW
>NZ_CP013126.1|WP_028700513.1|515762_517112_+|NAD(P)/FAD-dependent-oxidoreductase
MPALFSRFGYDPAFTKDRPKVAVVGGGFGGMAAAKALAAEGCHVTIIDKNPYTTFQPLLYQVATGGLNPGDVTYRLRSFTAKLGAHARFRRASVTDIDTDARLVHVDNGEPIPYDYVVLAQGVGANFFGIPGAAERSDTIYTRASSLRARDVIFSHLEALDTDKTRSFDVIIVGGGPTGVETAGTLAEMKSVGIPAIFPDVSIDRVHVTLVEMGPHLLAPFDAGLRHYTRKQLQRRGVDVRTETAIKEIREDSVLLGDGQTLPADMVIWAAGVGAHKKAVGWGFETGRGGRIVTDKNLRVHGQDRIFAVGDGAIIDENPLPQLAQPAIQEGELVASQVVHLERGEALQEFSYVDKGTMATIGRNAAVVELANGPKFTGFPAWLVWVMIHIYSLLGGRNRIQAMVNLGSRYLTFNREAGAIVGDVLTEDGEPESQKPESERPAASSKADD
>NZ_CP013126.1|WP_028700514.1|517252_518083_-|sulfurtransferase
MTPLLPTPLVSVDDLSDALAGPDGRRIVILDVSMGASAADPHIPGALRFDLDGPMSDQSTGLPHTMPAPDVLQESLRGLGISADSHVIVTETDFLFAAARPWWMLRAMGVDAVSILDGGNPAWERAGHPLVTEETPEPAPGDLVVEPRPGLLVDEEHVKRSLAAGETVVDARSRARFAGIEPEPRPGLRAGHMPGAVNLPYTELQREGRLLPVVDLASAVDRTAGRGPIVASCGSGVTACIVALAAVISGRDDVAVYDGSWSEWGRQGGPAVVTGC
>NZ_CP013126.1|WP_028700515.1|518213_518459_+|hypothetical-protein
MSRNTFVAVAAVVLAGGIVIARSRRSGRSSSEVGDKDLRHLQKRKPTGGRRTRRADPYADGHATPAGGDTRPKGAPAYFKA
>NZ_CP013126.1|WP_154662022.1|518443_518908_-|hypothetical-protein
MDSTPLVSRRLSLAAALLPWVTVVVPIRSTWKDLAVEEFLLDEGSIGLLAMTLLFGVTAVLALVPAARRWWGWCAAGVSLASAVVLAVYTVPGQVNWDGVDSQGRPTGGVELILPDFGWGILVLAWAAMTAAAVIALVTRRRAASARASGQALK
>NZ_CP013126.1|WP_028700517.1|519009_520143_-|hypothetical-protein
MRSSGTPREALVTAGAGVGLWLVQRVAVVVIWLIQGGSLPGDLMKWDAQWYARIAAGGYHWPVPQPGHTDPWLSDLAFFPGFPALTRAGTLGGLDARWATLVVAWIGFACAAGVIALVGREVGGAWTGVLLVLLWGAAPRSLVQILGYSEGWFIALVGLGLLMGLRRQWIRAGLAICVAGVIRPAVVPMGVLLGLAWVAAWPVFRRGVDSGERRRRFLGAALTPWGFLAYTVVVAHRTGRWDGYLLVQRAWGSSLGWSNEMFHQVREYWPIAPYNWTYFGLVAASVILYAALLVAMIAMREKPLLWGQVALVLLLTVFSVGYFQSKARFLLPAFPAFLPVARLLEKAPRWLCVATMVVITGLSTWWSIYVLGGRYSP
>NZ_CP013126.1|WP_157756364.1|520523_521948_+|hypothetical-protein
MTRRAMLAGTAALVGATTLMSTSPSRAQADNTFFKTFGGSVVPLPAGPRQTLSDGYIGALRIGPDGVPLTQLNGGWVIHPTILGNYLNSLLNSYETVSGGQPKNLARVVTTMEALLARAARRNGAVFLKYEFPWHAFNGDLPDPWYSSFGQSKFPQVAWRLWKITGERRWLQACRELVQAFYEGPVPGKTGLPWIAKVDPNHNLWLDEYPTPSGRESAVFNGHYYALHELSVYSQLSGDAQAQKLVSGAVQTLADYRNLCRHAGTFSHYFASTSANVPSYHYINTSCYLNVYNNTGWAPFATTVDQMISDWRFTEGKSAQLYLSGGYNHTIRKVTGSAGANAGSATTWKPGSNMVVASGARTQYVAFNGVWSRMDSGPRKGYWLLESIYGYPEGFDTDRCEYRFPRVLYFEKGKVTTFIADSRGHMTNPRVTTFNARSSAHTSLRAKVNGRQYAKLTDGSFAGRWAPLGGTVHF
>NZ_CP013126.1|WP_081685342.1|521999_524237_+|leucine-rich-repeat-domain-containing-protein
MRMSHAVTSATLCLGLIAAGTFYGPASPARAEGPSQPVITSVDTHVTSTAGGALVRLHGSGLTSDAMVKISGRSAEVRSASGGTMTVIAPAAPRGVAHIQVTTAGRTSDTNSTTAIAYVDQIPGTRPKARTTTDRTRLRPRSVTTAISDSNLALCVNDQLGLDPSTPPTPEQLSSLTALYCTDRTINSLAGISLLTNLQTLDVGGNTITDIGPLASMTGLKELGLQSNRVADLTPLSALTSLTRLDAWTNPVSSLAPLKSLTNLGYLDVSDTGVSSLEPLTGLTRLISLDANFTTVSSLTPLRSAAGLQELQLWQARVSDLTPLAGLTSLRYLDVSANRVTGITTLSRLTRLETLNLEDNDVADATALAGLTRMYSLNLSGNRISSVAPLAKLSALQWLFVQRNRIADLSPLSGLKPNSIEAQDQTVAAPVTTGKYTTFRMADRTGTSVTASGGFASYSGGRITFAHAGTTILSFRNSNATFTGTVLASCTYNIPMVTGDGTGDRIADLYGIGGDGKLHFFRGSATGGVSALPDPWQDAADATALVQIPDVNGDKRSDLLAREPDGQLLMRTGLGNGYLGTAKKFGTGWTSMDLIISAGHLSATSSNFLLARRHSDGSLVRYTLTSSGLSGTTIVGWRWGSMRAIIGAPDWNGDGRDDVLAIRDDGTLWLYTSSVRGTPNPGVRVGLGWSNFSTVTSPGDISGDGRSDLVAQRKDGVLFAYHLANRRFASPREIGRGLQDYRLIG

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Crispr_ID: NZ_CP013126_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013126_4

680900-680977

Orphan

Consensus_repeat	Method
GGCGGCACGCGACCAGCTGACGGCG	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP013126_4

>merge|NZ_CP013126|4|680900-680977|CRISPRCasFinder
GGCGGCACGCGACCAGCTGACGGCGCGGCCATGCACGGGGCGGCCTCGCGCTCGGCGGCACGCGACCTGCTGACGGCG

>NZ_CP013126|4|4|680900-680977|CRISPRCasFinder
GGCGGCACGCGACCAGCTGACGGCG	CGGCCATGCACGGGGCGGCCTCGCGCTC
GGCGGCACGCGACCTGCTGACGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013126.1\|WP_028701536.1\|672948_674616_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP013126.1\|WP_002546835.1\|669397_669745_-\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|223713
NZ_CP013126.1\|WP_015069148.1\|687440_688436_+\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|187558
NZ_CP013126.1\|WP_015069149.1\|686006_687395_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225121
NZ_CP013126.1\|WP_060539048.1\|681151_682411_-\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NZ_CP013126.1\|WP_015069156.1\|675023_675509_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|379804
NZ_CP013126.1\|WP_028701534.1\|677083_679069_+\|FAD/NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|379196
NZ_CP013126.1\|WP_071161980.1\|699553_699838_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_028701533.1\|679080_680790_+\|diaminopimelate-decarboxylase	unknown	unknown	gnl\|CDD\|143509
NZ_CP013126.1\|WP_015069150.1\|682915_685984_+\|DUF4981-domain-containing-protein	unknown	unknown	gnl\|CDD\|236673
NZ_CP013126.1\|WP_036938199.1\|689954_691373_+\|IS30-like-element-ISPfr9-family-transposase	unknown	unknown	gnl\|CDD\|225382
NZ_CP013126.1\|WP_028701541.1\|691522_692878_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|180907
NZ_CP013126.1\|WP_028701535.1\|675807_676995_+\|2,3-diaminopropionate-biosynthesis-protein-SbnA	unknown	unknown	gnl\|CDD\|274872
NZ_CP013126.1\|WP_015069142.1\|699834_700140_+\|CopG-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|279710
NZ_CP013126.1\|WP_008598604.1\|669857_670280_+\|arsenite-efflux-transporter-metallochaperone-ArsD	unknown	unknown	gnl\|CDD\|377741
NZ_CP013126.1\|WP_015069139.1\|700143_700437_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_097959151.1\|693266_694477_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP013126.1\|WP_154662081.1\|669226_669370_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|181958
NZ_CP013126.1\|WP_028701537.1\|672142_672952_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|366760
NZ_CP013126.1\|WP_028701538.1\|670308_672069_+\|arsenical-pump-driving-ATPase	unknown	unknown	gnl\|CDD\|275109

Protein	Function_ID	Function_description	E-value
NZ_CP013126.1\|WP_028701536.1\|672948_674616_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.07962e-17
NZ_CP013126.1\|WP_002546835.1\|669397_669745_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|223713	COG0640, ArsR, Predicted transcriptional regulators [Transcription].	9.08737e-17
NZ_CP013126.1\|WP_015069148.1\|687440_688436_+\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|187558	cd05247, UDP_G4E_1_SDR_e, UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	9.97922e-129
NZ_CP013126.1\|WP_015069149.1\|686006_687395_+\|MFS-transporter	gnl\|CDD\|225121	COG2211, MelB, Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism].	3.74411e-77
NZ_CP013126.1\|WP_060539048.1\|681151_682411_-\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	2.89616e-153
NZ_CP013126.1\|WP_015069156.1\|675023_675509_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|379804	pfam16242, Pyrid_ox_like, Pyridoxamine 5'-phosphate oxidase like. This domain, approximately 140 residues in length, is mainly found in general stress proteins in various Xanthomonas species. It is composed of a six-stranded antiparallel beta-barrel flanked by five alpha-helices and can bind to FMN and FAD, suggesting that it may help the bacteria to react against the oxidative stress induced by the defense mechanisms of the plant.	1.42039e-43
NZ_CP013126.1\|WP_028701534.1\|677083_679069_+\|FAD/NAD(P)-binding-protein	gnl\|CDD\|379196	pfam13454, NAD_binding_9, FAD-NAD(P)-binding.	2.59615e-20
NZ_CP013126.1\|WP_028701533.1\|679080_680790_+\|diaminopimelate-decarboxylase	gnl\|CDD\|143509	cd06842, PLPDE_III_Y4yA_like, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA. This subfamily is composed of the hypothetical Rhizobium sp. protein Y4yA and similar uncharacterized bacterial proteins. These proteins are homologous to eukaryotic ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC). ODC and DapDC are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. ODC participates in the formation of putrescine by catalyzing the decarboxylation of ornithine, the first step in polyamine biosynthesis. DapDC participates in the last step of lysine biosynthesis, the conversion of meso-2,6-diaminoheptanedioate to L-lysine. Proteins in this subfamily may function as PLP-dependent decarboxylases.	4.55736e-137
NZ_CP013126.1\|WP_015069150.1\|682915_685984_+\|DUF4981-domain-containing-protein	gnl\|CDD\|236673	PRK10340, ebgA, cryptic beta-D-galactosidase subunit alpha; Reviewed.	0
NZ_CP013126.1\|WP_036938199.1\|689954_691373_+\|IS30-like-element-ISPfr9-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	4.24052e-91
NZ_CP013126.1\|WP_028701541.1\|691522_692878_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|180907	PRK07251, PRK07251, FAD-containing oxidoreductase.	2.7292e-162
NZ_CP013126.1\|WP_028701535.1\|675807_676995_+\|2,3-diaminopropionate-biosynthesis-protein-SbnA	gnl\|CDD\|274872	TIGR03945, cysteine_synthase, 2,3-diaminopropionate biosynthesis protein SbnA. Members of this family include SbnA, a protein of the staphyloferrin B biosynthesis operon of Staphylococcus aureus. SbnA and SbnB together appear to synthesize 2,3-diaminopropionate, a precursor of certain siderophores and other secondary metabolites. SbnA is a pyridoxal phosphate-dependent enzyme. [Cellular processes, Biosynthesis of natural products].	5.31283e-136
NZ_CP013126.1\|WP_015069142.1\|699834_700140_+\|CopG-family-transcriptional-regulator	gnl\|CDD\|279710	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family. The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. The helix-turn-helix-like structure is involved in dimerization and not DNA binding as might have been expected.	0.00653122
NZ_CP013126.1\|WP_008598604.1\|669857_670280_+\|arsenite-efflux-transporter-metallochaperone-ArsD	gnl\|CDD\|377741	pfam06953, ArsD, Arsenical resistance operon trans-acting repressor ArsD. This family consists of several bacterial arsenical resistance operon trans-acting repressor ArsD proteins. ArsD is a trans-acting repressor of the arsRDABC operon that confers resistance to arsenicals and antimonials in Escherichia coli. It possesses two-pairs of vicinal cysteine residues, Cys(12)-Cys(13) and Cys(112)-Cys(113), that potentially form separate binding sites for the metalloids that trigger dissociation of ArsD from the operon. However, as a homodimer it has four vicinal cysteine pairs.	2.60017e-53
NZ_CP013126.1\|WP_097959151.1\|693266_694477_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	6.91127e-50
NZ_CP013126.1\|WP_154662081.1\|669226_669370_-\|hypothetical-protein	gnl\|CDD\|181958	PRK09564, PRK09564, coenzyme A disulfide reductase; Reviewed.	1.02399e-06
NZ_CP013126.1\|WP_028701537.1\|672142_672952_-\|ATP-binding-protein	gnl\|CDD\|366760	pfam01695, IstB_IS21, IstB-like ATP binding protein. This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.	2.63236e-57
NZ_CP013126.1\|WP_028701538.1\|670308_672069_+\|arsenical-pump-driving-ATPase	gnl\|CDD\|275109	TIGR04291, Arsenical_pump-driving_ATPase, arsenical pump-driving ATPase. The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).	0

>NZ_CP013126.1|WP_028701533.1|679080_680790_+|diaminopimelate-decarboxylase
MTEEPTLREACQGTPPLSARLEPWMQELLADPATCSSLLERYGSPLNVHDFSALPRNAAELTEVAEGSGVDLRISVARKANKTFGMVRAAHRAGLGVDVGSERELGQVLEAGVPPHDVVVTAAIKPDPVLRLALESRSLLVLDNLDEVAASRRVAEQVTGARSAEPGRPADGASGAPEPFPVALRLAPKPSDLIPPTRFGESARAWLELIDSGGLGDLLRVDGVHFHLHGYDPTARATALGEALELIDALRERGLAQDGAFVDIGGGIPMSYLDDAEQWDAFWQAHERQAPESGLGGGARAADDDRPAAAPDAGEDAPTAPLTWRREPLRQVYPYHQQVIRGPWLERFLGHEIRPGATAGQALRERGVQLRCEPGRSMMDGCGMTLARVIQRTSASDGVPLVGLEMNRTQCRSTSDDFLVDPILVRTGTRDDATDPSVAGAGQSRASERFEGFLVGAYCIEAELILRRRLAFPQGVAVGDVIALPNTAGYLMHILESASHQIPLASNVERVGGGEAGGSGGDHPSAEVADRSRMGGTDHSSTAVEGSDPRPDVPGFKRDGIDRVLPIRA
>NZ_CP013126.1|WP_028701534.1|677083_679069_+|FAD/NAD(P)-binding-protein
MAAAETPLRPAADAPLRLAVVGAGPKALYALEELTALLDAAGSATATADDAGAAASESSAASGLIVTVIDPVAVPGTGAAYHSGQPHHLRLNVTAAILDEPATGDFPAYPSWVQDPYPQLADEPYPPRAVVGEYLAQRWQQMIHGLSRHARVEHARARVTDLRREGSAWHLTTDAAPADVGPVDEVLIATGHAAGHRGALVHHWSSPLPLVPAVLPAERMLSAEQVPPGSRVAVRGGALTFIDACLTLTEGRGGTFTESTEVDASGGTEADVPARLVHHRGPHEPTVIRPITRQGLLLDAKPDPGSPLTGSGERAVEQARARFTSGQGMGPDAVLAIVVDAATAMLEGTPAPKKHASTSGRDARDTVAGSRAAVEHTLSTGAEPDLPRGAGRAEAALRRSIETAQGHRSPGPAWALGRVWQTLYSLVSAALRGSDAPEEEWARFRQTAQVLERFAFGPPLVNARKLLAMIDSGAVDLSWMDGGTGIDGNSIHVAPVTESSDATATGRHVDATATGRHDDAPSGGDVDVVIDAVLTPPGLLNLTDELAGSLLHRGLVQVRPGRRGAMIDEAGSPVGRDDAPLVAPDGRTVAGLALIGRPTEDHVIGHDSLNRHLHHEGRCWARRIADRVAGVADAAPADAAAPAAPADAAVPAAPAPAVAPE
>NZ_CP013126.1|WP_028701535.1|675807_676995_+|2,3-diaminopropionate-biosynthesis-protein-SbnA
MTHTSGSPQREHTSSTPADDRPPATPTEAATSGPDIPVGLDNAPEGPGVSAAGFASPVPAIVAGISEAIGNTPLIRLDSLFPDSGVEILAKLESVNPGGSTKDRPAMGMVRDALQTGRLAPGGTVVESSSGNLGVALARACNAHDVRFVCVVDARTNATTVRTIQALGGEIDLVSEPDPATGDLLTARFNRVKELLEEIPDAVNLYKYGNPANPRAHYDGTMREIAEATGHQVDVLMAAVSTTGTIGGCSAYIRDHGMSTRAIAVDAVGSVLFGGTAAPRPLPGMGAGVVTELSRQVQPDQVIRVEGLDCVVGARHLARSEGILAGGSTGGIVHALGGLIPSLEPGTRVVFVVHDGGVPYLETVYDDQWVRENLDADTDAIAEGIEQLRRTARRG
>NZ_CP013126.1|WP_015069156.1|675023_675509_-|pyridoxamine-5'-phosphate-oxidase-family-protein
MSTDQDFTQQDVVEKLRGTSIVMLTTARADGKLLSHPMTVQDVTDDADVWLFVGLQGDQADALRQGPEVNLNVSEAGSWLSVAGRAKFVEDRAKIAELWDDSAKSYFPDGVDDPNLALVLVTSESAQYWGLPGGKVAGVAQILKAKVTGGDTPGGTGTTEL
>NZ_CP013126.1|WP_028701536.1|672948_674616_-|IS21-family-transposase
MGSRVQLYADIRHDARVDGLSIRELARKHGVHRRTVRQALAAAEPPPRKKPVRTAPRLDPYKPAIDEMLTYDLTAPRKQRHTATRILARLRDEHGATDLSYSTVRDYVRVRRAQIDLEAGRRVEAMVPQDHAPGAEAEVDFGEVYVILDGVKTKCHMFVYRLSHSGKAIHRVYPTGGQEAFLEGHIEAFHALGGIPTRHIRYDNLTSAVVQVIHGGDRLRDENERWVLFRSHYGFDAFYCQPGIDGAHEKGGVEGEVGWFRRNHLTPMPEVATLDELNDKIRAWEHDDNTRRITGHANTIGQDHHAELPHLAPLPADDFDPGLILHPRVDRSALITVCMVKYSVPAHLIGQRVRVSLRASCVVVFEGRTVLATHPRRGTRGVTRVELDHYLEVLRHKPGAFPGSTALAQARAAGAFTAAHDAFWAAARKTSGDVAGTQALIDVLLLHRSLPSDAVIAGITSALSVGAISPDVVAVEARRHATTHTPAPASPTRGGTVVNLPPRRPTNPHQVIAHLPEDTRPLPTVTAYDELLRRRQPDPAPAPAETHHHTPTGTP
>NZ_CP013126.1|WP_028701537.1|672142_672952_-|ATP-binding-protein
MTTTSTSRPASLRRRQGLTEQAAQAAIDQACRRLRLPTIRAVVDDAVTAATKEQLTYQGFLAELLLAEVDDRDRRSTLRRIKSAGFPREKWLADFDFDANPSINPATINELATGDWIRRGDPLCLIGYSGTGKSHLLIALGTAAAEQGYRVRYILATRLVNELVEAADEKQLTKTINRYGRVDLLVIDELGYMELDRRGAELLFQVLTEREEKNAIAIASNQSFSAWTDTFTDPRLCAAIVDRLTYNAIIIETGTNSYRLAHTRARQAG
>NZ_CP013126.1|WP_028701538.1|670308_672069_+|arsenical-pump-driving-ATPase
MTQFLDNPPPHFFFTGKGGVGKTSIACATAVHLAHQGKRVLLVSTDPASNIAQVFGATIGNKITPIPQVPGLDALEIDPDEAAEAYRNKILEPVRAVLPIKEIEAITEQLSGSCTTEIASFNEFTDLLADTQATAGYDHVIFDTAPTGHTIRLLQLPGSWTSYLDNGKGDASCLGPMSGLEKNRATYRAAVEALTDPTSTRLVLVARAQQSTLREVARTLDELAELDIHATNLVVNGVLPAAAATDDLSRAIHDREQAALAAMPAALAALPRDTVSLKSVNMVGLEALATLFHDEDAPQADAQDTGGQGIGQQPHLAGLVDALPAEADHGLVMTMGKGGVGKTTVAAAIAIALVQRGKKVLLTTTDPAAHLSTTLGNDVDGLEVSAIDPEKAIQEYRDHVMASKGAKLDDAGRAALAEDLMSPCTEEIAVFQQFSRAVNKARDQFVIMDTAPTGHTLLLMDATGSYHRDITRHLDDDQRGHVTTPLMRLQDPDHTKIIVVTLPETTPVTEAQALASDLERANIHPWAWVVNNSLAAAHPTSPLLATRARSEQQQLDAVAATTNRMAVIPTQTREPVGTQQLTALSN
>NZ_CP013126.1|WP_008598604.1|669857_670280_+|arsenite-efflux-transporter-metallochaperone-ArsD
MPVIRVFEPALCCNTGVCGPDLDQELVDFTAAVNALKAQGVDVHRANLASEPAQFAEHPVVVKFLQAAGSEGLPLTLVDDVTVLAGRHPRRDELERYAGLNPTKDAQPQGGCCGPQQEAPAASTGCCGQPATTSTVSGCC
>NZ_CP013126.1|WP_002546835.1|669397_669745_-|helix-turn-helix-transcriptional-regulator
MTELLEAPMAAAEACAPGGGTISMEQAERVALVVKALADPVRLRILHHIAASRCSSVCACHMPEVFGVTQPTLSHHLKKLVEAGLVDKEMRGKWAHFTPRPEGLAALHEYLAMLG
>NZ_CP013126.1|WP_154662081.1|669226_669370_-|hypothetical-protein
MHVVCVGGSDAGISAGLRARELDPSTEVTVVVADAYPNFSICGIWTA
>NZ_CP013126.1|WP_060539048.1|681151_682411_-|IS256-family-transposase
MTAAHIVDPTRVLDQALGQASPDLLRSLLATMINMLLSADADQVAGAEYGRPDPDRLVQRNGYRHRDLDTRVGTVDVAIPKLRQGSYFPEWLLERRKRAESAMITVVADAYLAGVSTRRMDKLVKQLGIDSLSKSQVSRMAADLDAQVEAFRHRPLGEAGPFTFVAADALTMKVREAGRVINAVVLTATGVNADGHREVLGLQVATAETGPAWNTFFADLVARGLSGVRLVTSDAHAGLREAIAANLPGAAWQRCRTHYAANLMSVCPKSLWPAVKAMLHSVYDQPSAAAVDAQFDRLLDYVEAKLPQVHAHLDAARADLLAFTSFPVDVWRQIWSNNPQERLNKEIRRRTDAVGIFPNREAVIRLVGAVLAEQTDEWAEGRRYLGLEVLERSRIPQTPVSEDQTRLEGADPIPPELAA
>NZ_CP013126.1|WP_015069150.1|682915_685984_+|DUF4981-domain-containing-protein
MSIPKHHQGLEVLHENTLAAHAYFVPASAAVTDVVTARESSDRVQLLNGQWDFRYHHSVNDLDEAFMDPGCTVEGFAPITVPGTWQHQGYDAHQYTNVRYPIPLDPPHVPVDNPCGAYRTTFDHHADAAAPDTTLVFEGVDSCFYVWVNGHYVGYSQVSHATSEFDITEALVEGTNHMAVLVFKWCDGTYLEDQDKFRTSGIFRDVYLVDRPTRHLFDYFTTTQIHEAGATVRLRASYVGGPVETRATLLGADGTTVASGVLAEANDARGYSHAVELHVNRPRLWNPEHPELYTLLLEMPDEVVTDQVGLREVSIDDVVLRLNDCPVTLRGVNRHDSAPATGPTVDVAHMRRDLELMVRHNINAVRSSHYPNDPRFYQLCDQYGLLVMSEADNESHGTQAQFLADESWDNVVEHWNELIADSPDWTEATLDRVQRCVQREKNRPSIFSWSAGNECAYGCTLEVSLAWMKEFDPDRVTHYESAFYRNSKRSYDYSNIDLYSRMYPSQQEMLDYLAGDPDKPLVLVEYCHAMGNGPGDLEDYWQLIHTDPRLCGGFVWEWCDHAVLADHTDDGRPCYLYGGDSGEVIHDGNFCVDGLVWPDRRPHPGLLELKNVQRPARVVAHDPGAGMLTLRNDLDFTNLDEVVYLSWELVCDGIVLDRGDLSFTRPVPPHTETQVTCRPQLPRVGRCHLRVTQRLRVGDAVRAAGQELGFDEVAVPVADPRNQQSVQLLEAPPGGVSPAVEQDPSAITVRGDGFQYRFDTGTGMPTSMLVGDQEMFTAPAEVNIWRAPTDNDRRIRLEWERARYPYAAVRAHECSAQTLDGSVVVRARMTLDAATIQPILRLDASWTIDVAGRLRCQMDVTRTPGFPTLPRLGLRFFLAPELDQASWVGLGPGENYPDKRQASRHGHFTSSIDGLFVDYLRPQENGSRGDCDWVRVEQADAARGLTVTSPRPFSFNASRITQEQLSITRHDVELDPDDQVVLCIDHAMAGIGSNSCGPELLARYRVDDETYHVDLVLAPTRR
>NZ_CP013126.1|WP_015069149.1|686006_687395_+|MFS-transporter
MPTHAASSGKTYLTWGNKIGYGSGDIAGNVVYTFLSAFLMIYLTDQMGLNAGVIGTLMMVAQLFNGVTDIGFGALLDRTHTRMGKARPWMLWPYIGCAVTLVASFAIPGGLSETGKYIWFFLAYTLLNSVFFTANNIAYSALTALITRNSAERVQMGSIRFMFAFTTSMLIQTFTVQGVRMLGGGADGWRAIAIIYAVIGLAVNTISVLSVKELPPEELDEGHDPAAAERYSFKEGARILLANKFYLIILVIYLVQQIFTATLNMGIYFMTYVLGDATRLGAFAWAINIPLIIGLLFTPVLVKRYGQMYRLNIWGYVVAVLGRLGVVAGGYMGSIPLMIASSAIASLGMSPLQGTLNALIAEASEYTFLRTGKHIDGMMFSCTTLGVKIGGGVGTALAGWLLAASGYVSNATTQSSSAIHMLYFMYLWIPAIANLIILAFLTRLDVEKANRALRTSADRVTA
>NZ_CP013126.1|WP_015069148.1|687440_688436_+|UDP-glucose-4-epimerase-GalE
MSWLVTGGAGYIGSHVVRAFIEQGITPIVVDDLSSGHREFVPDGVDFVEGQVQDTSLLERTMREHDVEGVMHIAGYKYAGVSVARPLHTYSQNVQGTAAVLEAMQRVGVSRIVFSSSAAVYGTPDVDLVTEDHPTAPESPYGQSKLIGEWLLADQARALELTDGATPLQHVSLRYFNVVGSGTDEVYDTSPHNLFPLVIEALIEGRTPRINGTDYPTPDGTCVRDYVHVADLATSHVAAATAMAEGRELRPVYNLGSGDGLSVREIMDAMQRGTGHTFEPVIGERRPGDPARIVANGDAAARDLDWRMRHSIDDMVTSAWQARTAHPDISE
>NZ_CP013126.1|WP_036938199.1|689954_691373_+|IS30-like-element-ISPfr9-family-transposase
MRTGDVPEGLRRQWRADRALRPAMFSPGRPQPSRTVQRDFWRLIATGISTAEAALVVGVSIPVASRWFRHAGGMPPISLVEPSGRYLSFAEREEIAILKAQGKGVRTIAQALGRDPGTISRELRRNAATRGGKLEYRAMVAQWKAHEAAKRPKEAKMVTNPRLRDYVQDRLAGKVTHPDGRTVNGPDTPVWKGLNKPHRADRRWSKAWSPEEISRRLRIEFGDDESMRISHEAIYQSLFIEGRGALKRDLVTCLRTGRALRSPRERSRNKPHGHVTADVVISERPAEAADRAVPGHWEGDLIIGTGRSAIGTLVERHSRATILVHLPRLEGWGQTPPVKNGPSLGGYGAVAMNTALAASITALPQQLRKTITWDRGKELSAHATFALETGTKVYFADPHSPWQRPSNENTNGLLRQYFPKGTDLFRWTAEDLEAVAHTLNNRPRKTLGWRTPAEVFEEQLQSLEEAGVATTG
>NZ_CP013126.1|WP_028701541.1|691522_692878_+|FAD-dependent-oxidoreductase
MDVDLLVIGWGKAGKTLAGRFAAAGKTVALVERSPEMYGGTCINIACVPTKDLVVSAEERRDSDDPQEFFRTAVAGRDALIGTLNAANHQMLEKPGVTLVDGTARFTGPRTVVVDTAEGQVELTGETVVIGTGATSRRVDLPGFDSPRVFDSTTIQHIDPLPERLVIVGGGFIGLEFASMFTHFGSKVTILDRGEEFLPRVDRDVAEAVRQTLLDMGVTIEQGVRPTSLDDDGTHAVVHTTKGDFAAEAVLVAAGRVPVTGELGLEAARIEVDERGFVVVDDQLQTSVPGVYAVGDVNGGPQFTYISLDDNRIVWDAVMGQGTRRRSDRVAVPNTTFITPPLSMVGMDETQARKSGRNVLMAKKEVAKIAAMPRPKIVGETHGLFKLFVDADSQEILGATIFSIDSQELVNMVALAIRLGAKVSDLRDGIWTHPSSTEAFNEVLGTLEPLA
>NZ_CP013126.1|WP_097959151.1|693266_694477_-|IS3-family-transposase
MSTGNEKTRRQRRKFTAQYRHEAARMVIDSGRTIAEVSQELGLGPQLLGRWVKAEKETMTPSTLSPDEREELKRLRKENADLRMDNEFFGKSSGLLRCEASVSEKYTLMQAEKARYPIARMARLLKVSTSGYYAWVAAQQRDGDHLLPSLRARRRLDEAVRRIWVDSRSTYGYLRVCAQLRREGVVVDRKTVAASMRRQGLAGISPRRFRPVTTIPGTRTHSIPDRVKRHWDTGQVDRVWVTDITYLRTRAGWVYLCAIKDACSRKVIATVMSTTMTTDLVEEALRRARILRPNAPRKVIIHSDRGTQFTSEQMYECCRELHLDQSMGRTGVCWDNAMIESQWSVLKAEFYDRYEWDTPQQAIQGVEEWIHDFYNTKRLNSAIGYQTPVEFEAQHAAALTRAA
>NZ_CP013126.1|WP_071161980.1|699553_699838_+|hypothetical-protein
MLSVTFTHSAGRHGVSEQDAIWAIEHALLAKPSFQRSRLPDMPDPSLFVGPDTSGRIIEVMAVRTDDDLIIFHAMRARPQFVDQIRTPRKGAHR
>NZ_CP013126.1|WP_015069142.1|699834_700140_+|CopG-family-transcriptional-regulator
MTDPTTPDWDRMADWAESQAPLTDDSAPMLAGEQARQAGRQFLRGRPNVGADHATGAGQSRKRATRLDEQTDAALVARARREHKSVSAVIRDVLRDELAKS
>NZ_CP013126.1|WP_015069139.1|700143_700437_-|hypothetical-protein
MRYTLIWEEPPIDAVRRRRRRRAGGSAGDALERILNAGIDLAHAERAGYPLDEAELMALDRCDEIGGVRGIVAAEYGDPYPRDPQAPDDPGDPRWDF

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Crispr_ID: NZ_CP013126_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013126_5

889964-890063

Orphan

Consensus_repeat	Method
GGGGTCAGCGAGCGCCTGCGCGAGCGCAGGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013126_5

>merge|NZ_CP013126|5|889964-890063|CRISPRCasFinder
GGGGTCAGCGAGCGCCTGCGCGAGCGCAGGGGGACGCCGAACCCGGACGCAGACCCAACCCGCTCGAGGGGTCAGCGAGCGCCTGCGCGAGCGCAGGGGG

>NZ_CP013126|5|5|889964-890063|CRISPRCasFinder
GGGGTCAGCGAGCGCCTGCGCGAGCGCAGGGGG	ACGCCGAACCCGGACGCAGACCCAACCCGCTCGA
GGGGTCAGCGAGCGCCTGCGCGAGCGCAGGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013126.1\|WP_081685365.1\|886431_888147_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP013126.1\|WP_015068994.1\|890083_891214_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NZ_CP013126.1\|WP_015068986.1\|898864_899986_-\|sodium-ion-translocating-decarboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|377182
NZ_CP013126.1\|WP_015069002.1\|878986_879475_+\|DUF309-domain-containing-protein	unknown	unknown	gnl\|CDD\|377120
NZ_CP013126.1\|WP_036936932.1\|892508_893141_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226789
NZ_CP013126.1\|WP_015068998.1\|883820_884450_+\|ArsR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NZ_CP013126.1\|WP_028700782.1\|880007_881078_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_015068995.1\|888206_889925_+\|ABC-transporter-family-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173866
NZ_CP013126.1\|WP_028700778.1\|893302_894766_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143421
NZ_CP013126.1\|WP_015069004.1\|876761_877001_+\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|238219
NZ_CP013126.1\|WP_082632924.1\|885779_886154_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378990
NZ_CP013126.1\|WP_028700777.1\|897189_898611_-\|phosphoglucomutase/phosphomannomutase-family-protein	unknown	unknown	gnl\|CDD\|100093
NZ_CP013126.1\|WP_148279460.1\|877017_879042_+\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|225127
NZ_CP013126.1\|WP_028700780.1\|892077_892512_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_081583297.1\|881031_883824_+\|multicopper-oxidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|259871
NZ_CP013126.1\|WP_076692596.1\|891376_892078_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_051281742.1\|895713_897066_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669
NZ_CP013126.1\|WP_051281762.1\|894922_895717_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP013126.1\|WP_015069001.1\|879497_879872_+\|DUF488-family-protein	unknown	unknown	gnl\|CDD\|225730
NZ_CP013126.1\|WP_028700776.1\|899988_900471_-\|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein-subunit	unknown	unknown	gnl\|CDD\|236449

Protein	Function_ID	Function_description	E-value
NZ_CP013126.1\|WP_081685365.1\|886431_888147_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.1313e-88
NZ_CP013126.1\|WP_015068994.1\|890083_891214_-\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	6.30011e-141
NZ_CP013126.1\|WP_015068986.1\|898864_899986_-\|sodium-ion-translocating-decarboxylase-subunit-beta	gnl\|CDD\|377182	pfam03977, OAD_beta, Na+-transporting oxaloacetate decarboxylase beta subunit. Members of this family are integral membrane proteins. The decarboxylation reactions they catalyze are coupled to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis.	0
NZ_CP013126.1\|WP_015069002.1\|878986_879475_+\|DUF309-domain-containing-protein	gnl\|CDD\|377120	pfam03745, DUF309, Domain of unknown function (DUF309). This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.	1.03966e-24
NZ_CP013126.1\|WP_036936932.1\|892508_893141_+\|hypothetical-protein	gnl\|CDD\|226789	COG4339, COG4339, Uncharacterized protein conserved in bacteria [Function unknown].	3.60252e-20
NZ_CP013126.1\|WP_015068998.1\|883820_884450_+\|ArsR-family-transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	2.69226e-19
NZ_CP013126.1\|WP_015068995.1\|888206_889925_+\|ABC-transporter-family-substrate-binding-protein	gnl\|CDD\|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	8.51484e-143
NZ_CP013126.1\|WP_028700778.1\|893302_894766_-\|NAD-dependent-succinate-semialdehyde-dehydrogenase	gnl\|CDD\|143421	cd07103, ALDH_F5_SSADH_GabD, Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like. Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.	0
NZ_CP013126.1\|WP_015069004.1\|876761_877001_+\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	1.47766e-14
NZ_CP013126.1\|WP_082632924.1\|885779_886154_+\|hypothetical-protein	gnl\|CDD\|378990	pfam12911, OppC_N, N-terminal TM domain of oligopeptide transport permease C. Oligopeptide permeases (Opp) have been identified in numerous gram-negative and -positive bacteria. These transport systems belong to the superfamily of highly conserved ATP-binding cassette transporters. Typically, Opp importers comprise a complex of five proteins. The oligopeptide-binding protein OppA is responsible for the capture of peptides from the external medium. Two integral highly hydrophobic membrane spanning proteins, OppB and OppC, form a channel through the membrane used for peptide translocation. This N-terminal domain appears to be the first TM domain of the molecule.	5.39598e-10
NZ_CP013126.1\|WP_028700777.1\|897189_898611_-\|phosphoglucomutase/phosphomannomutase-family-protein	gnl\|CDD\|100093	cd05800, PGM_like2, This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four structural domains (subdomains) with a centrally located active site formed by four loops, one from each subdomain. All four subdomains are included in this alignment model.	0
NZ_CP013126.1\|WP_148279460.1\|877017_879042_+\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|225127	COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism].	0
NZ_CP013126.1\|WP_081583297.1\|881031_883824_+\|multicopper-oxidase-domain-containing-protein	gnl\|CDD\|259871	cd04208, CuRO_2_CuNIR, Cupredoxin domain 2 of Copper-containing nitrite reductase. Copper-containing nitrite reductase (CuNIR), which catalyzes the reduction of NO2- to NO, is the key enzyme in the denitrification process in denitrifying bacteria. CuNIR contains at least one type 1 copper center and a type 2 copper center in the protein. The type 2 copper center of a copper nitrite reductase is the active site of the enzyme. A histidine, bound to the Type 2 Cu center, is responsible for binding and reducing nitrite. A Cys-His bridge plays an important role in facilitating rapid electron transfer from the type 1 center to the type 2 center. A reduced type I blue copper protein (pseudoazurin) was found to be a specific electron transfer donor for the copper-containing NIR in bacteria Alcaligenes faecalis.	3.69553e-54
NZ_CP013126.1\|WP_051281742.1\|895713_897066_+\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	1.28692e-06
NZ_CP013126.1\|WP_051281762.1\|894922_895717_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	5.96029e-91
NZ_CP013126.1\|WP_015069001.1\|879497_879872_+\|DUF488-family-protein	gnl\|CDD\|225730	COG3189, COG3189, Uncharacterized conserved protein [Function unknown].	4.25455e-46
NZ_CP013126.1\|WP_028700776.1\|899988_900471_-\|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein-subunit	gnl\|CDD\|236449	PRK09282, PRK09282, pyruvate carboxylase subunit B; Validated.	1.32121e-28

>NZ_CP013126.1|WP_015068995.1|888206_889925_+|ABC-transporter-family-substrate-binding-protein
MTHRSPAGRRPAARLTSAAAGLVALSLVAAGCSAGSSTGSDSSTPRSTAAIGKTDYNPQPYEKLKDGGSYTTAGSFSGDDTQGLPWNLNTTLTGSRIWSWYNPVAITYSPTGEVQINKDYYTGATAKTVGGKQVVTITINPKAQFNDGSPIDWHAIESTWKVANGSNKNFQVGSTNGYDQIESVRKGTDDRQAVITFSTPYTAWPALFSNFINPKAATVANFNGAYSNKLEPQWGAGPYTVSSYDPNSKKIVFTRNPKWWGRKGKLDKRIYLDYPNAQAQVNAYKNGQLDYTSVSTPEDLSEVKNVKGAQIRQGGSPFQYSLFLNGKSPILSDVAVRHAVLAAVDRKQIADIQFQGLDYSEPLRGSALYYGFQKGYQDNVAAVLKSGASEASKILEAAGWKKGSDGIRVKNGKPLTISYTIFSDTALDKATAASLAASEKKAGINLKITTLDASQWASTINGGKFDTVLSGNRSTDPFGSFNLSSTYGSKNAANITGVGSPALDKEISAVNAIPDPTKQVQQANQVERKALSLYGQLPLYSGPSTYSVKKGLANVGATLLYSPLPETIGYQK
>NZ_CP013126.1|WP_081685365.1|886431_888147_+|ABC-transporter-ATP-binding-protein
MADHRPPHHPQPGIPAHRQRHPRRCLHRPHRDLAVLPRVRHQAARRLPGCDAPGRIGRPDHRPVDLPGAVGGPGAPDRLGHPHRRRPARCPRPRLRPWRHPVTLLNVRDLHVTFESERGPVRAVRGVDLNLERGRTLWLVGIREPAKRASDFPHEFSGGMRQRVVIAMAVANNPDLIIADEPTTALDVTVQAQILETLRTAQRETGAGVLLITHNLGVVAGYADDVDVMYAGKVVEQAPVEPAFAAPRMPYTIGLLGAVPTVSSQEREPLTAIPGEPPQLAAEPTGCPFADRCPAAVEACRQGEPELRRVGPDHAAACVRADEIAAGTLDVASLFGRGPSPEQGVDRHESEEVLRVRGLVKTYPITKGAILRRTVGRTTAVRGVDLDLRAGETLGLVGESGSGKSSTLMELMRLAPPESGSVELLGTPITDDLTSADRSRIRSGVQLVMQDVSGSLSPRLTVYDILAEPLQVSGLGRSAIESRVYELLDLVGVDRSAVDRFPSAFSGGQRQRIGIARALALGPRVVILDEPVSALDMSVQAEVLNLLVHLQKRLAPVNGATHQVACHAAAA
>NZ_CP013126.1|WP_082632924.1|885779_886154_+|hypothetical-protein
MTALPPADAATIAAESAVTDGAAVAPTPDETGEFVRIGRRRILLRRFLRNPSAITGSIIFLLLIAFSIFGGLLTPYSYDQPDFLALTRPRAASTRWTRHRAATTCWPRWCTPCSAPSSLPSRSR
>NZ_CP013126.1|WP_015068998.1|883820_884450_+|ArsR-family-transcriptional-regulator
MTENQHTLTDPGADSPADRVVEALRRRGGTASAAEVGADLGIHVSTARFHLDHLVEDGRARSGREKRATRGRPRTMFTLTPDPKEGPRAYQMLAGVLVDHLSRQDDAVALAHQAGVEWGRRYAGVDVTEILEQIGFAPCTTLVDDDQDEGPDGEARIALRHCPFIDVVQEHAALLCPLHRGVVEGVVGHPVTLEAHPGATCYVDLEQAG
>NZ_CP013126.1|WP_081583297.1|881031_883824_+|multicopper-oxidase-domain-containing-protein
MVLIQPIHTTGGPVPEITSRPQEDPGRPAPKGSDRTRRSAWHRKASAPVSVWLVALLAVVIGGHWIPQQRWLLVHMVTLGVATTSILVWGQYFTESILHEKLAEPDRKRQVWRIRILNLGVLACCVGMVPSWPWVVVAGATVVGLAMCWYALDLGLQVRRALPGRFDATVRFYSAAACLLPLGAIAGAVMAFSPEEPWRTRLLMAHQGLNIMGFVGLTAVGTLVTLWPTVLRTKMQPTQDRNGRRALWIMCAAVLVMTVGSLAGWWWLEAAGVLAELAGLCVVGVDLVRCAMKKPPRDFPGYSMGAAVIWFAIWLGWLAATILIKRDHLLQEDITALTVPVVVGFLLQLLLGAMSYLMPMVMGGGPAIVRATNARMHTLGALRATATNAGLVIWALAAGTWTSRIGLGLAILGMAGFLPAMVAMVKTGVGMLRAKRAAAEQKAPVPAADRADHSPEGRSGAPEPGKAAPASKMRTPTNHPAPAPTAPASRRSFAEAAIGLGAALGAVAVGRRLDGDTSGSGSSGHVTATGRTTTVKISMKDMHYHPSAVEVPAGNRLVVQLHNADPEQTHDLYFPSGAASRRLAPGQSQTVDAGVISAPTQGWCTIVGHRSMGMELEVTVGGASASQNGSSAATSTRRKIDLTKAPGAGFRTRDARLPALLAGRDHTMTLTVTESTQEVAPGATIRAMTYNGRVMGPAIHARIGDTMDVHLVNRGSMGHSIDFHAGTVSPNAVMRTISPGASLDYRFTLHRSGVWLYHCSTMPMSSHIAAGMYGAVVVPPHDLARADREYLLVQSETYLDAANGKEVDADKIAAETPDLTMFNGHANQYVFAPLTAKVGERVRIWVLAAGPSRGISFHVVGTQFDTVFKEGAYLLRPDNAEGGGAQALDLASAQGGFVEMVFEEPGRYTFVNHSFVEMERGARGLIEVIS
>NZ_CP013126.1|WP_028700782.1|880007_881078_+|hypothetical-protein
MVGAGFSLLASLDGALILLGVWSPVLTARLSQWHGPFMTLGFIGTVICLERAVALDRTWGYLAPLASGIGSILLASPAPVQIGLALLLLGQIGMLAIYIPLWRRSEDDATVIQAAGSACAVGAAGLLLAGVEVRSVIGWLSCYLVLTILGERLELSRLTMTRNRFLPAAALCLLAALVIQTASPKVGWPLLGVVLVVMSVWLIDKDVARVGMRRGGQAAYIGGMLMAGYVWLAIAGVVWIFSGPLGTGTGYDAAVHAVFLGFVMGMILGHAPIILPAVLRIRLDWSNWFWVPAVLLEASLVIRLGIGDGLGMPLAVQIGGTINVIALLSLIAVVVTHAHSRDGAHSAHPHDRRSRA
>NZ_CP013126.1|WP_015069001.1|879497_879872_+|DUF488-family-protein
MTTFQIANIRDDIREGSADSGYRVLVDRIWPRGVSKERAGLDEHRKEVAPSNELRKWFGHDPVRFDEFTAHYRAELDASGAAETFARDMAGHPLVTLLYGAKDHEHNQAVVLKQVLEELDGHTA
>NZ_CP013126.1|WP_015069002.1|878986_879475_+|DUF309-domain-containing-protein
MADRDRDAQGRPRNSRPRDGLGRPLPRGQEGVPVTPDDLELPGPETLEMAQELLDRGRPFHAHEVLEARWKNCPEAERDLWHGLAQLAVGVTHQMRGNTTGAIRLIGRGAMYLRPYATAAAPARVEEVDVAGILSWADATVTALEDGHGIDTVVTLRQKASS
>NZ_CP013126.1|WP_148279460.1|877017_879042_+|heavy-metal-translocating-P-type-ATPase
MRRRRMMSAIRRPGPRLAAAGILIAAALVMGRLGTDWALPGNIAMAAAAIISTIPIAAAALRALRSRTIGIDLLVTIASIGALAIGNYWEAAAVTFLFAFGHVLEQGAMTRTRSALTDLVRSAPQDAVLVRDGRTETVPTRTLRPDDVVLVAAGSSVPVDGTVISGSGAADESAVTGESMPAEKTPGDQVRSGTTLTSGMVQVRAEKVGSQTLLARIVARVEEAQDARGRVQTMMDRFGRWYTPAIIVLAIVVGLISGSLTLALTLLVIGCPGALVISVPVAVVAGIGRGARDGILIRGGEHLETAAKVDTVVFDKTGTLTTGHPELTDVVAYGAADEEEVLRWAALAEIGSGHPLAGPILDAARSHGVAPEGVPGEADAIPGRGLIADVLDAEHPQTRHRVVVGTVELAGQELGSDKESDTAWAARTSARLAGGGATPVTVVRDGVLLGVLAIADTIRADAPAALARLRRTGVTRLVMLSGDRQEVASAVADQLGIDDARGGLLPEDKLAAVQELRAGGAVVAMVGDGINDAPALAAADVGVAMGAAGSALAVETSDIALMADDLTRLPESLRLARRTRAVIRQNIVIAVATVTLLLAGVLLGGVTMALGMLVHEASVLVVIVNALRLLGRRARTREESRQDQAGKQDQPWQTSEHGGSRSGRPGASPQQQAA
>NZ_CP013126.1|WP_015069004.1|876761_877001_+|heavy-metal-associated-domain-containing-protein
MSTNEITTTHTVLRAEGFSCPSCVAKITGALEKLPGVGDVTVHFASGRIEADHDEARTSVDDLIAAVGKLGYPATASAF
>NZ_CP013126.1|WP_015068994.1|890083_891214_-|6-phosphofructokinase
MAKKKKVGILTAGGDCPGLNAAIRGFGKAAIRQHGMELIGFQDGVRGLAENRYIPLDGRALSGILTIGGTILGTSRDKVNRMVVDGETRDMIPTIKENYEKLGLDALVTLGGGGTARNANKLSKAGLNVLHLPKTIDNDIVGTDDSFGFSTALEIATDAIDRLHSTAHSHHRIILAEIMGHRAGWLALGSGIAGGADIILLPEVPYHLDSIVKAVEQRRKDGLNFSVIAVAEGARDETDALAMSGAQALVDESRTPDTKAAAKKAKKDLERSMRDNTIKLATQLEDATGLESRVTILGYVQRGGTPCAQDRLLATRLGTKGAQLVDDGQFGIMVTAQGTGTGTIPLKDVGGKVKYVPLDHPWVEAARSVGTSLGDD
>NZ_CP013126.1|WP_076692596.1|891376_892078_+|hypothetical-protein
MGAMHGWALTVDQRRSRMSEDLVPALQRVLAELPVLDDTGATPARPPRWDLPAERTAGDEVQAFTTDPGTLVAAVWAVCGQKLWWCGVGLGAVRTPLPGSTREAAGSAYIAARVAVEEAKKAINGVSVEVAEAPAPRLVQVLDVLAEVVGSLTSAELDVCDLYDRGMARPAIAGRLGISAPAVSKRLTTRRWEFLRRTRALAVDLAAEALSERTAQDQALSKRTVSKSTGRGD
>NZ_CP013126.1|WP_028700780.1|892077_892512_+|hypothetical-protein
MLIDVLVTLVLAVIAVPGGAPVVRAVFWAATPSAERRTSLWTAMWSRQTDDGVLRGGRWIGYLERLGIAATLLAGQPGGVAVIAGVKTLARYAELHSTPAPGTDAGQARRQSQAAIEQFIIGTLTSFIWAGMLALLTRRLWWVW
>NZ_CP013126.1|WP_036936932.1|892508_893141_+|hypothetical-protein
MSPDDSDLIRRWERLGVESTKAAGLGSRLIARWGRPHRFYHGLEHLRGALDALERFGGGRLEAVAVFFHDSVWTLPSDPDHGADEARSADLARTWLVGALPAEQIEEVARLVMVTADHLPEAADPPGCRVSDADLAVLAAPWPRYAESVAGLRVEAGLAGPGTAEDWSALRRGQIAELLGRPWLYRVAPPAWETAARANLTRERDLLTIL
>NZ_CP013126.1|WP_028700778.1|893302_894766_-|NAD-dependent-succinate-semialdehyde-dehydrogenase
MTTTDRSLPTDLPNQLLIGGRWVDADESRTFDVIDPATEDVLISIADAGEDQGLDALTAAVDAQDAWAATAPRERAEILRRGWEIVTERKDDFARLMTLEMGKPLAEAYGEVTYGAEFLRWFSEEAVRIRGDYGILPEGKVRQLVMKRPVGPCLFITPWNFPLAMATRKSGPALAAGCTVIIRPASSTPLTTLLFAKAMQDAGLPDGVLNVITGLDHGVTDKILADRRLRKLSFTGSTPVGRHLLSQASEHVLRTSMELGGNAPFIVFEDADVDAAVEGAKGAKMRNMGEACISANRFIVHESVAEEFTEKFTAYMSGLVVGDGMEKGTDVGPIIGEGDRQKINALVESARNAGGTVLTGGEIPSGRGYFYPPTVITGVPADAEVMTTEIFGPVAPITTFSTEEEALRIANSVPVGLAGYVYTRDVDRIQRMGAKLETGMVGANIGVFSNAAAPFGGVKESGLGREGSYQGIEEFLETIYVALPNPA
>NZ_CP013126.1|WP_051281762.1|894922_895717_+|ABC-transporter-ATP-binding-protein
MLSRTVHQTSPAQAGDPLAGHPPVIIADSLVKTYGPTRALDGVGTIIGAGESVAVMGPSGSGKTTLLHCLSGILAADSGSVELLTPEGGIRVDGLDAAGRARLRRERLGFVFQQGMLVPELTAVENVALPLMLNGVDRTTAEARASQWLAALGLPGLEGRRIGQLSGGQAQRVAIARAQVTDPAIVFADEPTGALDSRTAEEVMGALLESTTGRGRTLVVVTHDLNVARTCGRILTLADGRIVADQRRPGTAAHTENSRQEALR
>NZ_CP013126.1|WP_051281742.1|895713_897066_+|FtsX-like-permease-family-protein
MNATWPILRMLARPTLADRRSWALPVTAFAVIATIILDVTAGAAMFWRIPGDMATTYRGLAGVAVVLLVLPLVTLASSATRLSARRRDDRLSALRLLGATSGTLRLLTLAESGAYALAGSLIGVVGYAITLPLLAMLPFNGGPIGVGSLLLGPLPLLGVIAALVVLALASSAVSLRRVEISPLGVAMRSSAQGVSRMRIIAGGALLAVAAGAAAIAPRLGMAAAPIIVIMVVLLAIGAGLTVINIVGPKLLAVHFRSRLRRARTAPALVAARMVLESPKAAWRQVSALGSVCFVGVAGGAGVALLSRTSGSGADRAEAILIGDIRTGIILTIVFAFATVACSVGINQTSAVLDRRDIEVGLDLVGMTAAEQEEVRRRAVLGPLWFVMAVSVLSSVAVLLPLVGAALVMSPVTMAVTAGVIAAGAGMVALGLRATHGTLAGVLEEGLARVE
>NZ_CP013126.1|WP_028700777.1|897189_898611_-|phosphoglucomutase/phosphomannomutase-family-protein
MADEIEFGTGGWRAVIADTFTKANVRRVAQGLADRIHDEDVADRPVVIGYDQRFLSPEFAWWAAEVLAGNGIHVRVIDRPAPTPMIMWTVRDKGCAYGMAITASHNPATYNGIKIFTEGGRDAEVEVTGPLQAHINTIADADIKALGRDEAVEQGLVRVQTSMNWYIDSILDQVDLDVIRHAHLKIVLDPMFGVSKTCLQTILLTARCDVDTIHERRDTLFGGRLPSPNSKTLKALAGVVVERGADLGIATDGDADRLGIIDDRGNFLHPNQILVLLYSYLLEEKGWIGPCVRNLATTHLLDRVAEAHGQTCYEVPVGFKWVSSKMAETGAVIGGESSGGLTVKGHIAGKDGVYAGTLLVEMIARKGKPLSQIYADIEKRYGRLEMIEDDFSFAPEAKEGLKKRIYIDQDLPDFDVEIDHISDMDGIKVYFANGGWIIVRFSGTEPLLRVFCEMPDAASAQRCIDAVVAKYGL
>NZ_CP013126.1|WP_015068986.1|898864_899986_-|sodium-ion-translocating-decarboxylase-subunit-beta
MDPTTWDNLLRGILNVQWQGLVMIAVGLLLIWLAIAKEYEPLLLLPIGAGCVLANMPVSSMLGEHGMLSIFYNVGVANELFPLLIFIGIGAMTDFGPLLENPKMVLLGAAGQFGIFLTLILALVLGFDRPEAASIGIIGAIDGPTSIYVSGKLAPGLLGPITVAAYSYMSLVPIIMPPVMRLLTTKKERTIRMAYSQRQISARTRIIFPIVVTIVVGILVPFALPLIGSLMLGNLMRESHVVERLTGAAQNELTNIVTLLLGLAIGSTMVGTQFLKVQTLMILVLGLVAFVLDTAAGVCFGKLLNVFSRDGFNPLIGAAGISAFPMAARVVQQEVSREDDGNFVLMHAMGANAAGQVASAMAGGVLLALMGSF
>NZ_CP013126.1|WP_028700776.1|899988_900471_-|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein-subunit
MRRYTITVAGTTHEIEVEETSATQFQVRVDGQQVEVELTAHQDVGDQPVVPQIDPRHESAPKAPRVPQQVRTRATGSPSPALTGGADLAYSMTAPMPGVIASVDAGPGDEVAKGQTVLVLEAMKMKNELHASRSGVIAEVLVAEGDQVKYGQTLLCFEKA

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Crispr_ID: NZ_CP013126_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013126_6

1480903-1481004

Orphan

Consensus_repeat	Method
GTCTGAGCTGGCATTCATCGGGCACTCCTCG	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP013126_6

>merge|NZ_CP013126|6|1480903-1481004|CRISPRCasFinder
GTCTGAGCTGGCATTCATCGGGCACTCCTCGGGCAGGTGTAGACGGTCGAATCGGTGATGGTGACGTTGTCGTCTGAGCTGGCATTCATCGGGCACTCCTCG

>NZ_CP013126|6|6|1480903-1481004|CRISPRCasFinder
GTCTGAGCTGGCATTCATCGGGCACTCCTCG	GGCAGGTGTAGACGGTCGAATCGGTGATGGTGACGTTGTC
GTCTGAGCTGGCATTCATCGGGCACTCCTCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013126.1\|WP_015071790.1\|1489239_1489893_+\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuD	unknown	unknown	gnl\|CDD\|132048
NZ_CP013126.1\|WP_076692575.1\|1473982_1475677_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|238038
NZ_CP013126.1\|WP_015071806.1\|1470577_1471486_-\|FAD:protein-FMN-transferase	unknown	unknown	gnl\|CDD\|376782
NZ_CP013126.1\|WP_015071807.1\|1469592_1470585_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP013126.1\|WP_081583500.1\|1477466_1478390_+\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|224629
NZ_CP013126.1\|WP_028700679.1\|1489942_1490689_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP013126.1\|WP_015071796.1\|1482323_1483799_+\|Family-2-glutamate-cysteine-ligase	unknown	unknown	unknown
NZ_CP013126.1\|WP_015071808.1\|1468912_1469596_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP013126.1\|WP_028700678.1\|1487528_1488428_+\|ectoine/hydroxyectoine-ABC-transporter-substrate-binding-protein-EhuB	unknown	unknown	gnl\|CDD\|270223
NZ_CP013126.1\|WP_028700666.1\|1468185_1468908_+\|VIT-family-protein	unknown	unknown	gnl\|CDD\|153123
NZ_CP013126.1\|WP_154662034.1\|1477281_1477440_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_028700669.1\|1471482_1472004_-\|FMN-binding-protein	unknown	unknown	gnl\|CDD\|226484
NZ_CP013126.1\|WP_028700672.1\|1476385_1477129_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|182593
NZ_CP013126.1\|WP_015071794.1\|1484355_1484679_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP013126.1\|WP_015071791.1\|1488436_1489240_+\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuC	unknown	unknown	gnl\|CDD\|223836
NZ_CP013126.1\|WP_028700676.1\|1481763_1481976_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_148279585.1\|1472006_1473530_-\|ferric-reductase-like-transmembrane-domain-containing-protein	unknown	unknown	gnl\|CDD\|99795
NZ_CP013126.1\|WP_148279583.1\|1484672_1487252_-\|glycoside-hydrolase-family-65-protein	unknown	unknown	gnl\|CDD\|224471
NZ_CP013126.1\|WP_154662035.1\|1481057_1481741_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_015071795.1\|1483838_1484339_-\|SRPBCC-domain-containing-protein	unknown	unknown	gnl\|CDD\|176910

Protein	Function_ID	Function_description	E-value
NZ_CP013126.1\|WP_076692575.1\|1473982_1475677_-\|HNH-endonuclease	gnl\|CDD\|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	1.12227e-13
NZ_CP013126.1\|WP_015071806.1\|1470577_1471486_-\|FAD:protein-FMN-transferase	gnl\|CDD\|376782	pfam02424, ApbE, ApbE family. This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis. It acts as an FAD:protein FMN-transferase, catalyzing the attachment of an FMN residue to a threonine residue of a protein via a phosphoester bond in such bacterial flavoproteins.	7.85249e-36
NZ_CP013126.1\|WP_015071807.1\|1469592_1470585_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.0184e-37
NZ_CP013126.1\|WP_081583500.1\|1477466_1478390_+\|restriction-endonuclease	gnl\|CDD\|224629	COG1715, Mrr, Restriction endonuclease [Defense mechanisms].	1.31175e-89
NZ_CP013126.1\|WP_015071790.1\|1489239_1489893_+\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuD	gnl\|CDD\|132048	TIGR03003, ectoine_ehuD, ectoine/hydroxyectoine ABC transporter, permease protein EhuD. Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.	4.80077e-75
NZ_CP013126.1\|WP_015071808.1\|1468912_1469596_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.29703e-53
NZ_CP013126.1\|WP_028700678.1\|1487528_1488428_+\|ectoine/hydroxyectoine-ABC-transporter-substrate-binding-protein-EhuB	gnl\|CDD\|270223	cd01002, PBP2_Ehub_like, Substrate binding domain of ectoine/hydroxyectoine specific ABC transport system; the type 2 periplasmic binding protein fold. This family represents the periplasmic substrate-binding component of ABC transport systems that involved in uptake of osmoprotectants (also termed compatible solutes) such as ectoine and hydroxyectoine. To counteract the efflux of water, bacteria and archaea accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.12816e-81
NZ_CP013126.1\|WP_028700666.1\|1468185_1468908_+\|VIT-family-protein	gnl\|CDD\|153123	cd02432, Nodulin-21_like_1, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	1.17894e-98
NZ_CP013126.1\|WP_148279585.1\|1472006_1473530_-\|ferric-reductase-like-transmembrane-domain-containing-protein	gnl\|CDD\|99795	cd06198, FNR_like_3, NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P) binding domain. The N-terminal domain may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Ferredoxin is reduced in the final stage of photosystem I. The flavoprotein Ferredoxin-NADP+ reductase transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) which then transfers a hydride ion to convert NADP+ to NADPH.	4.3573e-47
NZ_CP013126.1\|WP_028700672.1\|1476385_1477129_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	3.11759e-15
NZ_CP013126.1\|WP_028700679.1\|1489942_1490689_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	9.34602e-140
NZ_CP013126.1\|WP_015071791.1\|1488436_1489240_+\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuC	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.05368e-70
NZ_CP013126.1\|WP_015071794.1\|1484355_1484679_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	3.87209e-15
NZ_CP013126.1\|WP_148279583.1\|1484672_1487252_-\|glycoside-hydrolase-family-65-protein	gnl\|CDD\|224471	COG1554, ATH1, Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism].	0
NZ_CP013126.1\|WP_028700669.1\|1471482_1472004_-\|FMN-binding-protein	gnl\|CDD\|226484	COG3976, COG3976, Uncharacterized protein conserved in bacteria [Function unknown].	3.75958e-15
NZ_CP013126.1\|WP_015071795.1\|1483838_1484339_-\|SRPBCC-domain-containing-protein	gnl\|CDD\|176910	cd08901, SRPBCC_CalC_Aha1-like_8, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	1.96802e-52

>NZ_CP013126.1|WP_081583500.1|1477466_1478390_+|restriction-endonuclease
MAPVLRVLSDGEIHVLKDIRDAAAEVLNLTAEARAETIPSGQLRYQNRCTWAVSYLKHAAAIESVARGRYRITEEGRGLLVRHPQRIVEADLEEIAGYDPKDSWNSRTAKRALPDGSPGLADDVCPAPTSGTLDELSPTEQVEQAVDQLKAEVAEELLTRLRGNDPDFFERAVVEVLLGMGYGGADKRGKVIGGTGDGGVDGVIDQDALGLDQIYVQAKRYAEGNNVGRQTLQAFVGALQWKNVTRGVFITSSDFTREALDFARTVSTRIILINGARLAELMIRYHVGVQVKETYWIPAIDEDFFVD
>NZ_CP013126.1|WP_154662034.1|1477281_1477440_+|hypothetical-protein
MITGDLRNRIDSVRDAFWFGGILNPLEVILEGQRADGEFVTSLQSRAFTGEL
>NZ_CP013126.1|WP_028700672.1|1476385_1477129_-|sulfite-exporter-TauE/SafE-family-protein
MSIGSLVLLLVAGAAAGLVGYISGLASLVSYPALLAVGLNPLLANTTNTLAQVGAGMGATLRAGRQVWAGGRRRTLQQLAIAAIAGAAGGALLVATGESSFGKVAPWLILFASLMMLASPHLWRLRGESGHWAGYLVALVPVCLYGGYFGAGAGVVFLAAVLMLTTQEYRQSVLMKSVLLAVSNLTASIIFICFTTVDWLVVAVMFVGQLIGGSLGPAVQRHVPNSVSRWVIAVGGVVMACWLWMRG
>NZ_CP013126.1|WP_076692575.1|1473982_1475677_-|HNH-endonuclease
MRRDFWELSGVIEQALDAIDHSGDARMPAVKKVAAMTKARALADRMAALAAVYTDLVARSGATEATAGSPLSDYLAATEGRTSSEANGLVHQASRIGADPAVRDAALAGTVSPGKAAAIGRVLRELPRHDMTPDQRQAAADVLLGQAAGGATTRQIAGSTDRILEQVAPNLAPTPEGRAAEAERQRRRAIRERELTFTDTGKGSVRIFGQVPQMEGDLLRSVVGACVERGRGDERRELEALKIQRASGDLSAGEYLAARTALQEREHRTTAQRQADALTDMIAALQDQGKIPAAGGETPRVVVTLDYMKLLQLAVGAAATGTRPDGTMLDKVLVARLQAALTGTSETGADVPASLVRQACCDAGLLPVVLGDASEILDVGREHRLVTPPIRKALALRDGGCIVPGCTVPASACQAHHVVPWWAGGVTALGNLVLVCRHHHGLIEPHRYNPGSDQWRIDFDQTGTPHVHPPRRMRGDLPADHPDARQNSALSPRPEGIEPVDAATNAGLWQDSAHSPAAGVLENAGPVGSAIPGLVELEPGAEDDREYSVHPPGERGPTQDALIA
>NZ_CP013126.1|WP_148279585.1|1472006_1473530_-|ferric-reductase-like-transmembrane-domain-containing-protein
MNPTTTLATPRRAAPPTSGDIRRQGAPQSSTGRPPARRRLSRQHWQYAATAVIWLTSLFVVAIWVKGGGIEDAVSLGSNLFMSIGRLSGLVSANLLLLQTILLAQIPVFERGFGRAGITRMHRLTGIWSFSLMVAHIVLITMAYSLQGRMGLLSQFWDFTLHYPDMIFADIAVLLIILVMVTSARRARRRLRYESWHLLHLWAYLGVALAIPHMLSTGGDFLTSPLATAYWWTLWGVAAASIVIFRVGMPLMRSLRHGVRVSRVIPDGSRGVTVQMTGRDLDRLGAHAGQFFTWRFLDGHGWTRGHPFSLSAAPTATTLQISARVVGDGTRRLARLRPGTRVLLEGPFGHMTGQERGEGGLLMLAAGAGVAPMVSILEEEAFAPGQAVLVTRDHDAAELMRSEAIRRLVREKGLVHRPMDGPRARRGASWLPAGHAGWSGARLLQRLAPRSGRIGIDRCEVYVCGPDPWMDAVLRDLARAGFSADRIHSESFNPVPEPSPAPERQNH
>NZ_CP013126.1|WP_028700669.1|1471482_1472004_-|FMN-binding-protein
MKKAFTATMGAVSAVVLAGSYYASLRGAEPSATYVPQTTTGSATSGATSTSGATSGTSSSSSGSTSTSSNSTSSKSTAASSLKDGTYTGSSVQNPFGTVQVQVTISGGKITSVKVPQYPTGHHSDEINQQAVPTLVNETISAQSSQVDMVSGATFTSQGYTTSLQNALDQAKA
>NZ_CP013126.1|WP_015071806.1|1470577_1471486_-|FAD:protein-FMN-transferase
MTGATTPLLKTHRLVRTAEIMGTVVSVHVILDRGEDDGNLSESPLPDSAASDSPVPDPAAPDDAVAAIERSFGELREMDRIFSTYRADSDISRIRAGSLTVEEADPLVALVRRACDRAEVVTGGLFSARWRGGFDPTGYVKGWAVERAFNRWLRPLLGLDGVIAVGMNAGGDMQLATRPDADWRWRVGIADPSRPGMLLATTELTDGAVATSGTAERGAHIRDPRSAKPPTTGAAGATVIADRLSDADVWATAAVVAGINDLGWVARARHTSGLVVGYDGRIRRWAAGDEVDAVRKAGSAVS
>NZ_CP013126.1|WP_015071807.1|1469592_1470585_+|HAMP-domain-containing-histidine-kinase
MTLRPRAADDRSIRSSTLRIGLMVGVTSALVIAGGIAILLWRISARSRPEAAEGMRRDHGHDHVVVDVNDVVPWLVVFGIAAVVLLGVIAWYSARRAVAPLAEALRRQRHFVADASHEMRTPLSALVSRTQILERRRARGEPIDDVIARLRGDAEAMSEVLTDLLTAAAADAGSLQEDAPDTPAHPMEALGRAAERMEPLASPHDVRIEVTGGSTASVQLAAPTLERICVALIDNAIDHSPQGGVVAVSCAQKGSTVEIRVGNQGPEISEEDRARAFERFARGAETGRHRGFGLGLALVREVAIRARGSVEIEETSPAGTVFLLRLPAVS
>NZ_CP013126.1|WP_015071808.1|1468912_1469596_+|response-regulator-transcription-factor
MTLPDVLYAEDDDQLAEMTVEVLSEYYDVDHVADGAEALDHALHRSYGVIVLDRRLPGMDGLALVRAIRQARIATPVLLLTALGAVDDRVEGLDAGANDYLVKPFAFEELLARMRALHRGFTAAGRRRRIGEWILTPDTQAIYSPTEARIPLTATETALLDVLAASPEHIFSRQELVGAVHRADQDEDRETVSTASVDTYVHYVRRKTVPEIIETVRGRGYRLGDPR
>NZ_CP013126.1|WP_028700666.1|1468185_1468908_+|VIT-family-protein
MDENVKPHEDEQHATNTGQKLNWLRAGVLGANDGIVSTAGVVIGVAGATPHNVAAIATAGIAALVAGAFSMAGGEYVSVSTQRDTEKALIAKEKWELENMPEEEREELADLYRQRGLSEHLAHQVAEELMAKDALAAHAEIELGIDPDHYTSPWAAAASSFVSFTVGALIPLIMILLPVGEHRIWIAAAAVVLGLFLTGLISATLGGAPRGRAIIRNVLMGSATMVATYLIGLAFGTAVL
>NZ_CP013126.1|WP_154662035.1|1481057_1481741_+|hypothetical-protein
MDKLTGMDPGSLADWISAIATVAATVAAVFAGFYAYKALRIEQAGDAERHEDRRRAQAEQVNAWAEHIRPDPRSPGFNTTGSNGVVQNSSGHDGVRLVVKLQNLSNAPVYAVRIGFILGRRPREGEVPDGVHPPKRPLYADWEFLLPPTDEPLVLVEFNWRAMQAWQEWRLRQESMNHMDARPYVELTFQDGSGTWWLRDARGRLTDISENDAVHRFEYPNAAGPLR
>NZ_CP013126.1|WP_028700676.1|1481763_1481976_-|hypothetical-protein
MRPCPSCGSYKRIELAPSFYECTALVAPSKDSATGEPVPCGVHYLDTSDRLTPVPLTPFGTRFDSLITGS
>NZ_CP013126.1|WP_015071796.1|1482323_1483799_+|Family-2-glutamate-cysteine-ligase
MGRDTSSTTYTRSERTRYRLKLHENLETFARYLPRADFSDAATIGIEMEINLTDADGHPVRRALDALDAIGNDEFQTEIGAHNIELNLPAVPVAGRGLEHLEDVARQRLHDARIAVEEIGVELVPVGMLPTLTEDDLRSEGWRNPENRYKALDNAILEARGEDIHIHVQGDDEIDLTIDSIAPESACTSAQLHLQVPPSQFAAAWNAAQAIAGPQVAVAANAPFFLGQAGWVENRIPVFTQATDTRPPEFANQNVRPRVWFGERWINTVFDLWEENVRYFPAILPESRQAAGQALLTEGAAPRLHELVLHNGTIWRWNRPVYDPGSGGRPNLRIENRLLPTAPTVLDQISDAAFFYGLVGRLVHDPRPLWSRMPFSDARANFQACAKDGLTADVVWPGLGSVPVAELVGEVLIPLAREGLVIQEVDDDLIDRYLSVIEARAHTGHNGAAWQRRMVEQLESVWMGREEALAEMTRRYRQNQVTGKPVHTWDI
>NZ_CP013126.1|WP_015071795.1|1483838_1484339_-|SRPBCC-domain-containing-protein
MTDDNTPTSPDDEPLTELSFTVSGRVSRPVAEVYEAVADPDQLSHYFTTGGAHGRLESGATVSWDFHDFPGRFPVTVVEATPPRRIEIRWGADKPEDGLTETTVVFEFSPIDEGRRTLVTITESAWRATSPGARNAFGNCEGWTGMLAALKVWVEHGINLREGFYA
>NZ_CP013126.1|WP_015071794.1|1484355_1484679_+|winged-helix-turn-helix-transcriptional-regulator
MTDAKGTPSDDDLVFKALASPVRRQILDLLKESPRTTGEVCAKIEDLDRTTVLQHLRVLETAGLVNGDKVGRQRRLTLAPLPIKRIYDRWIGDYARAAVDLLESLGQ
>NZ_CP013126.1|WP_148279583.1|1484672_1487252_-|glycoside-hydrolase-family-65-protein
MGAGRRGPAPEGGTVDTLDPDADPLDRMRYPVDPWELRETEPPVADARTAETLFAVGNGYLGIRGTSPEGHDATSPGSYVNGFHETYPIHHAEEAYGFARVGQEMIPVPDATVMRLYVGDEPLHLPVADLEAYERRLDLRSGILTRTVVWRTPSKVRVRVVSRRMVSFTRPHLAVMELEVTPLDGDLGLTVVSTVVNRIDAQTALAEDEAGDASLATPLQAELESHPAGPVPDPRKSSKLGAHVLVSTHLGSEGTCTSLGYRAAASGMTLAVGVDHDVTADGPISQYHEESPDAATREFRTRARSGSTLRVVKYAAYHTSRSSASSELAQRCRRTIHDARDVGVDGLVAEQRAWCEGFWARSDVEIAGRPELQQAVRFNIFHVAQAAMCSAGHGIPAKGLTGNGYSGHYFWDGEVYVLPFFSYTTPEVSRSALRFRCTMLPAARRRAHEINMSGALFPWRTINGHEASANYAQGTAQYHIDADIAYALMLYVRTTGDRDFLTRDAIDMLVETARMWADLGFFRTDGQDAFHIHGVTGPDEYTTVVDDNLYTNIMARGNLRDAVAAVRGLRRDRPEQYARMVKRVVLKPDEVALWEHAADAMAIPYDEQLQVHPQDDRFLTKEVWDLPHTSASDFPLLLHYHPLVIYRFQVIKQTDVVLAEFLHSGEFTAEEKARDFHYYEPLTTGDSSLSAVAQAIMAAEIGHDAEAVGHFRELLFVDLADTHHNTDDGIHIASAGGVWSALVYGFGGLRDDPAGGGVRLEPRLPAAWEGLTFRITVQGTRVRVELTHGRIALSVEEGPGTRIEVCGTSYDVSPDSPVVISPQPRERLGEMPTLDDIVGQVRADGTVITPRLPSRSAHH
>NZ_CP013126.1|WP_028700678.1|1487528_1488428_+|ectoine/hydroxyectoine-ABC-transporter-substrate-binding-protein-EhuB
MLHARTPLSITKRLAAVTTGLALLAGMTACSGDGKIPEAAGASGGGLTVEKAKQQGTLNIAIGNEPPYTKIAGDGSVTGAEPDVVRAVAKRMGIKNVKGTVTPYDSMIPGLKAGRWDTVAAGLFMKQSRCSQVIYTSPVIVSTESFAVPTGNPKKLTTIADVTKDPKLKVAVLKGGFEEGILDGIKLAGGQKVVVSDAQTGVEALKSNRADAFLLPTLSLTDLKKTTGGFDVTKAISDAPVTGSGAAFATTDKAFADAYNAELEKFKKTSEFDSIMSKWGFDADAARKATVTELCKSKG
>NZ_CP013126.1|WP_015071791.1|1488436_1489240_+|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuC
MDALLNFRPLLQSGFVTTLIVTVLGALVALIIAFLVGVARYSKNRILSIPAGIFIEVFRGTSLIVQMFWLFYVLPFFGIDLPPMVTAVIALGFNEGAYAAEIVRSALAAVPKGQNEASIALSLSPRRTLWRIKMPQAIAIMLPSLGNVLVDLFKNTSLVSLVTVVELTFAAQQIRTSTGQTLAVYGFLLVVYFVVSLLLGRLVALAERVVSRRFGTGGPGRRSTGRRTAAAAGPAGVSPVSVPAQVSPMSVPAQVSPVSVPARGGVS
>NZ_CP013126.1|WP_015071790.1|1489239_1489893_+|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuD
MWDPDFAAFVFPSLLRGLGVTIEITLIGSAIALVLGLIVAILRNLRIPVLQQVLWFYVEFIRGTPVLVQAYFAFFVMPKLGVSIDPLQTGILVMGINYSAYMAEVYRAGIESIPKGQWEAVRALSLPGSRAWRRIIIPQAVPPIVPALGNYVIQMFKDSAILSAITVTEMMSRALSAGSSYYRYIEPLTIAGLLFLVVSYLSSILVRRLEKRLVINQ
>NZ_CP013126.1|WP_028700679.1|1489942_1490689_+|amino-acid-ABC-transporter-ATP-binding-protein
MIEFRAVHKAWGANTVLDGLDFKVSHGEKVTIIGPSGSGKTTILRILMTLETPDSGAVLVDGQTLWPVQGSRRGGGRAQDAIRREIGMVFQHFNLFPHLSVVDNIIEAPINVLGLPKDQARAEAADLLERVGLTDHADHKPHQLSGGQQQRAAIARALAMRPRLLLFDEPTSALDPEMVGGVLDVIREVADSHAITMLLVTHEMRFASEISDRVVMFDSGTVVEQGSPDQVFGNPTNERTRRFLSALS

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Crispr_ID: NZ_CP013126_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013126_7

1585926-1586064

Orphan

Consensus_repeat	Method
GTCGCGGGCCCGGCGCAGCGGTTCAGGTCTGCGTCCGCGTCCGGGTGCTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013126_7

>merge|NZ_CP013126|7|1585926-1586064|CRISPRCasFinder
GTCGCGGGCCCGGCGCAGCGGTTCAGGTCTGCGTCCGCGTCCGGGTGCTGCCTGCTCGGGCGGTGACAGGCCCGGTGAGGGGGTCGGCGTCGCGGGCCCGGCGCTGCGGTTCAGGTCTGCGTCCGCGTCCGGGTGCTGC

>NZ_CP013126|7|7|1585926-1586064|CRISPRCasFinder
GTCGCGGGCCCGGCGCAGCGGTTCAGGTCTGCGTCCGCGTCCGGGTGCTGC	CTGCTCGGGCGGTGACAGGCCCGGTGAGGGGGTCGGC
GTCGCGGGCCCGGCGCTGCGGTTCAGGTCTGCGTCCGCGTCCGGGTGCTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013126.1\|WP_081583496.1\|1579223_1580093_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|366837
NZ_CP013126.1\|WP_028700875.1\|1582302_1583226_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270324
NZ_CP013126.1\|WP_015071700.1\|1593240_1593996_-\|AzlC-family-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224215
NZ_CP013126.1\|WP_015071701.1\|1592938_1593244_-\|AzlD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377512
NZ_CP013126.1\|WP_028700876.1\|1584633_1585791_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224050
NZ_CP013126.1\|WP_015071706.1\|1587725_1588271_-\|LytR-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379163
NZ_CP013126.1\|WP_051143581.1\|1576168_1577239_+\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176237
NZ_CP013126.1\|WP_157756383.1\|1577845_1578763_+\|aromatic-amino-acid-DMT-transporter-YddG	unknown	unknown	gnl\|CDD\|183277
NZ_CP013126.1\|WP_051143580.1\|1592040_1592790_+\|DUF559-domain-containing-protein	unknown	unknown	gnl\|CDD\|367957
NZ_CP013126.1\|WP_015071713.1\|1580447_1581971_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP013126.1\|WP_015071698.1\|1594318_1595662_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273344
NZ_CP013126.1\|WP_015071710.1\|1583995_1584637_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NZ_CP013126.1\|WP_015071716.1\|1578763_1578967_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_015071718.1\|1577431_1577662_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_015071705.1\|1588283_1588577_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl\|CDD\|227737
NZ_CP013126.1\|WP_015071711.1\|1583318_1583999_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NZ_CP013126.1\|WP_015071697.1\|1595812_1596487_-\|septal-ring-lytic-transglycosylase-RlpA-family-protein	unknown	unknown	gnl\|CDD\|223868
NZ_CP013126.1\|WP_015071707.1\|1586143_1587652_+\|potassium/proton-antiporter	unknown	unknown	gnl\|CDD\|235410
NZ_CP013126.1\|WP_015071703.1\|1590629_1591805_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|224090
NZ_CP013126.1\|WP_015071704.1\|1588709_1590338_+\|DUF853-family-protein	unknown	unknown	gnl\|CDD\|283518

Protein	Function_ID	Function_description	E-value
NZ_CP013126.1\|WP_081583496.1\|1579223_1580093_-\|HNH-endonuclease	gnl\|CDD\|366837	pfam01844, HNH, HNH endonuclease. His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.	2.5221e-13
NZ_CP013126.1\|WP_028700875.1\|1582302_1583226_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270324	cd13606, PBP2_ProX_like, Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold. This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.08106e-128
NZ_CP013126.1\|WP_015071700.1\|1593240_1593996_-\|AzlC-family-ABC-transporter-permease	gnl\|CDD\|224215	COG1296, AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism].	8.00143e-36
NZ_CP013126.1\|WP_028700876.1\|1584633_1585791_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	7.40873e-129
NZ_CP013126.1\|WP_015071704.1\|1588709_1590338_+\|DUF853-family-protein	gnl\|CDD\|283518	pfam05872, DUF853, Bacterial protein of unknown function (DUF853). This family consists of several bacterial proteins of unknown function. BMEI1370 is thought to be an ATPase.	0
NZ_CP013126.1\|WP_051143581.1\|1576168_1577239_+\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176237	cd08276, MDR7, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	6.85782e-157
NZ_CP013126.1\|WP_157756383.1\|1577845_1578763_+\|aromatic-amino-acid-DMT-transporter-YddG	gnl\|CDD\|183277	PRK11689, PRK11689, aromatic amino acid efflux DMT transporter YddG.	1.93978e-113
NZ_CP013126.1\|WP_015071710.1\|1583995_1584637_-\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	9.18235e-39
NZ_CP013126.1\|WP_051143580.1\|1592040_1592790_+\|DUF559-domain-containing-protein	gnl\|CDD\|367957	pfam04480, DUF559, Protein of unknown function (DUF559).	0.000304047
NZ_CP013126.1\|WP_015071713.1\|1580447_1581971_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	3.39204e-41
NZ_CP013126.1\|WP_015071698.1\|1594318_1595662_+\|hypothetical-protein	gnl\|CDD\|273344	TIGR00927, retinal_rod, K+-dependent Na+/Ca+ exchanger. [Transport and binding proteins, Cations and iron carrying compounds].	1.08862e-05
NZ_CP013126.1\|WP_015071705.1\|1588283_1588577_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl\|CDD\|227737	COG5450, COG5450, Transcription regulator of the Arc/MetJ class [Transcription].	1.15513e-09
NZ_CP013126.1\|WP_015071701.1\|1592938_1593244_-\|AzlD-domain-containing-protein	gnl\|CDD\|377512	pfam05437, AzlD, Branched-chain amino acid transport protein (AzlD). This family consists of a number of bacterial and archaeal branched-chain amino acid transport proteins. AzlD is known to be involved in conferring resistance to 4-azaleucine although its exact role is uncertain.	5.60609e-10
NZ_CP013126.1\|WP_015071706.1\|1587725_1588271_-\|LytR-C-terminal-domain-containing-protein	gnl\|CDD\|379163	pfam13399, LytR_C, LytR cell envelope-related transcriptional attenuator. This family appears at the C-terminus of members of the LytR_cpsA_psr, pfam03816, family.	1.66934e-15
NZ_CP013126.1\|WP_015071711.1\|1583318_1583999_-\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	4.42462e-51
NZ_CP013126.1\|WP_015071697.1\|1595812_1596487_-\|septal-ring-lytic-transglycosylase-RlpA-family-protein	gnl\|CDD\|223868	COG0797, RlpA, Lipoproteins [Cell envelope biogenesis, outer membrane].	2.89184e-33
NZ_CP013126.1\|WP_015071707.1\|1586143_1587652_+\|potassium/proton-antiporter	gnl\|CDD\|235410	PRK05326, PRK05326, potassium/proton antiporter.	0
NZ_CP013126.1\|WP_015071703.1\|1590629_1591805_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|224090	COG1168, MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism].	3.2424e-120

>NZ_CP013126.1|WP_028700876.1|1584633_1585791_-|ATP-binding-cassette-domain-containing-protein
MISFTDVVKVYADGTRAVDGLPLEAPTGRITVLVGPSGCGKTTSLRMINRMIEPSSGTIAIDGRDVASLNPDELRRGIGYVIQSGGLFPHRTVVDNIATVPRLLGRSRRQARSEAMELLERMGLDADLAGRYPAQLSGGQQQRVGVARALAADPPVMLMDEPFSAVDPQVRAQLQDEFLRLQSELGKTIVLVTHDIDEAIRLGDEVAVLRPGGTLAQLDPPSRLLADPADDFVADFLGRDRGYQRLGFTPAPPLPLADETTVALGTEAEEARRRAAAQSPAWRRPWLLVVDEQNSPLGWVRPESVTGQVERTDLHRGGTVARADGSLRAVLDAALSSPARRGVVVDGHGGLLGTVLAQDVLALIEDDGDDGAGPEAPGADGGEPS
>NZ_CP013126.1|WP_015071710.1|1583995_1584637_-|ABC-transporter-permease
MSWFLSHTDQVWGLLGHHAALAALPLLIGVLVALPLGWLARRHRALYTPMVAGAGLLFTIPSLALFILMPLILGTGILDPTNVVVALSLYTLALMVRTVADALGSVPPQVTSAARAMGIGSLRRFLTVELPLATPAISAGMRVAAVSNVSIVSVAALIGVPQLGSLFTDGFNRTFVTEIVVGLVACIALALAFDAVIVVATRLVTPWTRGRAS
>NZ_CP013126.1|WP_015071711.1|1583318_1583999_-|ABC-transporter-permease
MNLLWDWLANPVNWAGPDGVWARLAEHLAYSGAALLIAAAIGIPLGLWIGHTGRGRAVTVNLVNGMRAVPTLGLLFAAVLVIGPRLHGDAAFQVPAIVVLVILATPPILAGTYSGIDAVPPDARDAARGMGMTPGQVLGRVEVPCALPLIFSGVRSAALQVIATAILAAYVGLGGLGYFLQLGQGSRDYGMMAGGAVLVALLALAVDLILAGVQRLTLSPGLRTRT
>NZ_CP013126.1|WP_028700875.1|1582302_1583226_-|ABC-transporter-substrate-binding-protein
MRHRRVLAAALAVVTTMAIAGCGGSSDPLAEGSASGSASGSGGIVVGSANFPENELLADIYAGALNHQGVKASTKLNIASRETYIPALKKGEINLIPEYTGNLARYFDKSASISDSATADASLKKALPKGLTALTPAPAENKDSMVVTKQTAEQKKLKSISDLSASASGMVLGAPPEFKTRVDGVSGLKREYGLTFKEFKPLDEAGPLTVQALKNGQVQVANLFSTDPNIAANGFVVLDDPKNLFGAQNIVPVMTSSKASPKATKALDAVSAKLTTPVVQKLVEKVVIDKQDASAVAQQWLKANDLG
>NZ_CP013126.1|WP_015071713.1|1580447_1581971_-|serine-hydrolase
MITAEEIDQRAIGRIVEEAVSGWSICAPTWAAAVFDRSGVIAFASAASQGFERPARGDIFRIASMSKSFLVACMLLLVERGDLDLDAPVDRYIPSFQTPSTDVVTVKMLISNASGLPEDNGWSDHNLDLPRAEFIALLRKGFHFTEPPGQAYQYSNVAFTVASMILEIVSGERYETFLNHEILEPLGLDSTRYRAGDDPQSAPLARGFSTFDRGISWVAREFAEPGATAPVGALFSTVDDIAQWSAWLSAPFQADAHGGGDVARPRLSLLSGASRARMQRIHTPIPSIAGRWTSPRDDAAGYGLGLFVEHDSRFGPIAQHSGGLPGLSANMRWQLDSGIGVVAYATSEGQPVSDRAADLLDAVLRARDVPARHIRLWPQTFEAARRIDSMLRGGADHRKVSDLLAGSVFADMPAEIRRNQFEAAVARAGGLSHDVAPLADRALWCVSAAQLVWRLPCARSDLQVRIELAEVARQPVQRLVIEPLGAELAGLPADRDLVVRHHRPVLP
>NZ_CP013126.1|WP_081583496.1|1579223_1580093_-|HNH-endonuclease
MKRYFSGEVFQAHLKELSSVVTEHNEIAAYAAEIRAGGQFGLGTSGTGSRSSLATFENTSRHDYRRDRNVAHYQALNVHNCSLQVVRNASADPLKYLIKYFGVEATEEGLAQVEKLGETISRLENAVNNLKTREADITGEFNPPKFILKHYEKQFTERVGVNLSPISVPCPEYVFEYVSAGGNSSQRTTVKLNTPTIDGLIEALSERIRRRRSAAGQRALMTARFREEIKRRDDYTCRYCSVSLDDEPHLLLEVDHIVPVSRGGLSTEDNLQTLCWRCNRSKSNKMIDA
>NZ_CP013126.1|WP_015071716.1|1578763_1578967_-|hypothetical-protein
MTPQAHGQQEELAQRWQDVATAMWRRAVDQRRDNAGARDAALAQVAAQTAANVLAGLHAPAPEDLIY
>NZ_CP013126.1|WP_157756383.1|1577845_1578763_+|aromatic-amino-acid-DMT-transporter-YddG
MASTPQAVQSRRATAIGVAAILLWSGIVGLIRVTTQHFGATLGPSLIYTLAAALLWLTRRPKSLRGFSARYLLLGGGMFVIYEVALAMAVGLSDDAHQTIEVSIVNYLWPTLTVALAAVVNRRERRPGLLIIPGVLLATVGVVGAVGGEAGLSPTRIAANVMSNPLPYLLSLMAAAVWAAYSVFSPRLAGGRDGITVFISGVAAALWIVNLVSPAPVGDITASGVAGLIGAAAVIASGYASWNVGILHGNITLLASASYATPVLSTAVSSLLLGAVLPLTFWGNVLLVVAGSLAGWWATRRTGRR
>NZ_CP013126.1|WP_015071718.1|1577431_1577662_+|hypothetical-protein
MMKTSELFATQLVAFQAARDALDRRADDDGVDPPAGRITRNGAIVETTSAELTDAVDSGDLPGIQGPPQIGSTPRP
>NZ_CP013126.1|WP_051143581.1|1576168_1577239_+|NAD(P)-dependent-alcohol-dehydrogenase
MWTSRELLDLRGDTRAEGRTVFTYRFDHLDGLDSLTRHEEESPSPQRGEVLVRVRSVALNYRDIAIPLGRYVWDARPGLIPCSDAAGEIVETGDGVDSFEPGDRVVSCFHSRWFGGRPPANLMLDTYGSGKDGWLTQYAVVSQDAVVKIGDELSFGEASTLPCAGVTAWNALSGPSPIRPGDTVLTQGSGGVSIFAIQLAKALGASVIATTTSADKEALLRDLGADRTINTRDTPEWGGVVRDMTGDGVDRIVEVVGPQTIHQSLAAIRWNSEIVLVGFLSSTGPDINYFTLKGSGASIRSIGVGDRTMLEELIRVVAAAGIRPVIDSTYSFNEAPQAFRHLADGRHTGKIVIELT
>NZ_CP013126.1|WP_015071707.1|1586143_1587652_+|potassium/proton-antiporter
MPLFDLDLLVGAAVALLAVFAARVSSRLGLPALLLFLLVGMMLGPLGFGIQFSDAGMAHGLGFAALVLILAEGGLSTKWSSIKPALGVAGLLATVGIGGSIALMAVFAHFALHLPWTVAVLLGAVTAPTDSAAVFSVLRGVSIPTRLRSILEAESGLNDAPTVLVVIAMTGLAAGHQPSGGIPGLIGSIVVELAGGILLGVVMGWIAVRITRRVSLPSSGLYALAALAWAVLAYGVGVWVGVSGFASVYVASVVIGNGRLPYRNATRSFAEGVGWMAQIGLFVMLGLLADLDRLTWTEVLEGVVAGLFLTVIARPLSVALCASWFKMPPRHQAFVSWAGLRGAVPIILATIPLAARIPEAGKLFDIVLVFVVVFTCIQGPTLAAAGRLLGLVDPDAATDVDIEVAPLDEIDAVLLQVHVPVDSHLIGVTVRELRLPRNAFISLIIRADESFVPHASTALMRADELLLVTPEAERRQVEERLTEIGRGGRLARWNGLRVKAEE
>NZ_CP013126.1|WP_015071706.1|1587725_1588271_-|LytR-C-terminal-domain-containing-protein
MTQSARHYLKLVATPITLLVLLAIIVVGFWYGWKALTAPFGPKAVPCVNTNVGKSLTTKSIELDVVNGGHTRGLAKQVANQLTAKGFSVTDTGNTDERVKQTVIVGVAKDSPEVKLVSAFFPKSTVRVDTTRVDHSVTVMVGENYGGFNAKAPTSLAVSGPVCLPSPSATPSPSGSATPAS
>NZ_CP013126.1|WP_015071705.1|1588283_1588577_-|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MIFKRVGDSRPYPDHGYVQKQWSEIPPVQVRLDQLVTTKSTLDLGSLLEDDSTFYGDLFAHVVAWRGELYLEDGLHRALRAALQQRQTVHARVLELH
>NZ_CP013126.1|WP_015071704.1|1588709_1590338_+|DUF853-family-protein
MSQTPRESEPVAEAVDDALIDAITTGYTFEEPALDLGALSTDAGAVPSARVRIPLSMVNRHGLVAGATGTGKTKTLQVMAEQLSAAGVPVFAADIKGDLSGLASAGEASDKLAARTAKLGQQWAATGYPVEFYALGGAGRGIPVRATVSSFGPVLLSKVLSLNDVQESSLGLVFHFADKAGLPLLDLKDLQAVLNHLGSEEGKADLKGIGGLSSATLGVIIRKIVTFADQGAAEFFGEPEFDTADLMRTAADGRGIISLLELPDLADRPALFSTFLMWLLADLFSDLPEVGDAERPKLVFFFDEAHLLFDDASKAFLDAIAQTVRLIRSKGVGVFFVTQTPKDVPDDVLAQLGSRVQHQLRAHTPNDAKALKQTVATFPKSSYDLAEVLQSLGIGEAIVTVMDPDGAPTPVARTKIFAPTSLMAPTPDAQIDAAVKGSSLYSKYAEAVDRDSAYEMLARKLADGAQRAAEEKRAAEQQAAQEQAAEQQARQAPRAEARPAGRGRQEKSVVDKVLGSSVVRQFARSAGREIVRSLFGTARRRS
>NZ_CP013126.1|WP_015071703.1|1590629_1591805_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MTQFDFDSPTTDWLKARGTARWHDVADGVIPLWVAEMDFPVAPPVQAAIQDIVTKQAYGYPRDNGLKEAWANWAKNHQGLEVDPAKVTVLPDVLTGVRLALRTFSPAGSPLVLPTPAYMPFWDVPGLIGRRIISVPMITGADGRSTFDLEGIGRAFAQGARSIILCSPYNPLGRVFTETELLGLSEVVEEHGAFVVADEIHGPLVPAGGEAQGRTVPYASVSEKAAAHSINLMSASKSWNLAGLLTAVGTLFTDENQRLWKKEVHELETEGASTVGMAANLAAFTSGQPWLDEANEYIHANAVWLHDELARELPQAHFTVPEATYLGWIDFRDYGLPDNAGTWLLKNARIRLNDGPTFGPGGEGHARINLATPRYLLVEALGRMADAVNSR
>NZ_CP013126.1|WP_051143580.1|1592040_1592790_+|DUF559-domain-containing-protein
MVIRSDVVDDPDAWMVAAHQWRPSAIITGGAALRALHGLPIGFPIVVADHLDRASTERVRFLRTRFPPELLIDEGAGAFTVDEVSVLVCAALGDFAPVCHALREGWVTLDTLHEAAALLPPRSWLGMAAPELLRDLRDTPWSVAELLVQRHLRKARITGWVANPTLIIAGKEYEPDLLFRRRRLIVEVVGLEFHSGKEAVRRDISRAADLLAAGYRIVSVTADMVKFEPERVLGLIASQLGWYELRGST
>NZ_CP013126.1|WP_015071701.1|1592938_1593244_-|AzlD-domain-containing-protein
MSIFLMIPVAAAITFGLRFIPLLGIDRLKGHDSVERLSALMPGGIMIILVAYTLVDPGREGPLWTWLVAIAVTVAVHLWRRSPLITMLTGIGAYALLAALV
>NZ_CP013126.1|WP_015071700.1|1593240_1593996_-|AzlC-family-ABC-transporter-permease
MPETASTPTRSGWIDDLRWAVHASGPVAMGYVPLGMALGALVVNLGLHWWLAPVMATAVYAGSMEFLLAGFLVSAPGLASVALATLAVNFRHVFYPLAYPTHLLGRPWQKVLGAWQLTDEMYALMAGGTRPQNSRQVLMLSSVTQFWWVSGTVLGTAIGNLVPAGFRGLDFAMTGLFIALALNFFLSSAAWRVAGYAAVGIGAALLLPGPFLAWSLSVFTLCCLAEVWVVERRDAGPDDAEGQDDERREAR
>NZ_CP013126.1|WP_015071698.1|1594318_1595662_+|hypothetical-protein
MDISAMDPQSIQQLFDAEVVGPEGEAIGTVEQIFADDVTGAPTFVTVKDARTGAESFLPVSGADYNGRRVEVPFSQDVVQAAPSANGGEDLSPEREAEVYGYYGIRAPRRSRQEEAEPDDSWGEDAEFTPAQEPSGETQSDEAEGDDGASDEQDEAATDEPGEQDEAVTDEPGDPDEAAPAVVPEDATAQTVLGQDEPQFEPTEEAEDPATEFRSDVEIDEETDPAVPDEASADENPAEETAVLAGGSFPGAATSAGLVTAGSAAAAGSEPDRSDDAIATGDPDAVLDADDEGLAAGTEVDDAALSTDRLDGESPEAAREDEAESPDDEADSDEPDEDEAGGDASEADDQSESDDRSAASAIPGLPAGATLRKYVVTEMVTVQVPVRREVVCWVDAEGGVHELEPVEAPEATQKKDLHDPATWWFGSEAASETGDDKGPEHEEGPES
>NZ_CP013126.1|WP_015071697.1|1595812_1596487_-|septal-ring-lytic-transglycosylase-RlpA-family-protein
MTSTRGAHTSLRRLATLAATTGLVFAGATVGQAHAAPQQAPSRTVPAAGSVVYKKWAWATVNVNVHKWANASSANVVVLGKGRALGVITTNTAKGWVKVNYKGQAGYIQTRYVKIASTGVNPLKKAASTSGAVGTCKASYYGEGSRTANGERFNPSAMTAAHKTYKFGTKLKVTNKANGKSVVVRINDRGPYVSGRCLDLSTGGFKKIASTSAGVATVTYQVVR

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Crispr_ID: NZ_CP013126_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013126_8

2124878-2124988

Orphan

Consensus_repeat	Method
TCGGGGGTCGCGGGGGGGTCGTCTCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013126_8

>merge|NZ_CP013126|8|2124878-2124988|CRISPRCasFinder
TCGGGGGTCGCGGGGGGGTCGTCTCCCCGGTTGGTCGGCGCGTCGGGGGTCGCGAGGGGGTCGTCTCCCCGGTTGGTCGGCGCGTCGGGGGTCGCGAGGGGGTCGTCTCCC

>NZ_CP013126|8|8|2124878-2124988|CRISPRCasFinder
TCGGGGGTCGCGGGGGGGTCGTCTCCC	CGGTTGGTCGGCGCGTCGGGGGTCGCGAGGGGGTCGTCTCCCCGGTTGGTCGGCGCG
TCGGGGGTCGCGAGGGGGTCGTCTCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013126.1\|WP_028700961.1\|2118611_2120324_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NZ_CP013126.1\|WP_028700959.1\|2121642_2122296_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213052
NZ_CP013126.1\|WP_051281809.1\|2132107_2132887_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_015071183.1\|2134935_2136783_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP013126.1\|WP_015071185.1\|2132915_2133899_-\|type-I-pantothenate-kinase	unknown	unknown	gnl\|CDD\|235466
NZ_CP013126.1\|WP_015071191.1\|2127620_2128031_+\|YccF-domain-containing-protein	unknown	unknown	gnl\|CDD\|236975
NZ_CP013126.1\|WP_028700962.1\|2117020_2117641_-\|superoxide-dismutase	unknown	unknown	gnl\|CDD\|223678
NZ_CP013126.1\|WP_071162058.1\|2117772_2118615_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|378961
NZ_CP013126.1\|WP_028700960.1\|2120320_2121634_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223692
NZ_CP013126.1\|WP_015071190.1\|2128409_2128853_+\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NZ_CP013126.1\|WP_028700963.1\|2116152_2116842_-\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|235919
NZ_CP013126.1\|WP_028700957.1\|2123221_2124112_-\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|211337
NZ_CP013126.1\|WP_028700958.1\|2122618_2123209_-\|methyltransferase	unknown	unknown	gnl\|CDD\|225370
NZ_CP013126.1\|WP_036937246.1\|2124108_2124813_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP013126.1\|WP_028700964.1\|2115504_2116152_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366312
NZ_CP013126.1\|WP_028700954.1\|2130748_2132101_+\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237672
NZ_CP013126.1\|WP_015071193.1\|2125027_2125513_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP013126.1\|WP_015071188.1\|2129804_2130521_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235914
NZ_CP013126.1\|WP_015071189.1\|2128875_2129403_+\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NZ_CP013126.1\|WP_015071184.1\|2133984_2134809_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181382

Protein	Function_ID	Function_description	E-value
NZ_CP013126.1\|WP_028700961.1\|2118611_2120324_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	1.03222e-75
NZ_CP013126.1\|WP_028700959.1\|2121642_2122296_-\|hypothetical-protein	gnl\|CDD\|213052	cd12087, TM_EGFR-like, Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases. PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER, ErbB) subfamily members include EGFR (HER1, ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and similar proteins. They are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane (TM) helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. They are activated by ligand-induced dimerization, resulting in the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Collectively, they can recognize a variety of ligands including EGF, TGFalpha, and neuregulins, among others. All four subfamily members can form homo- or heterodimers. HER3 contains an impaired kinase domain and depends on its heterodimerization partner for activation. EGFR subfamily members are involved in signaling pathways leading to a broad range of cellular responses including cell proliferation, differentiation, migration, growth inhibition, and apoptosis. The TM domain not only serves as a membrane anchor, but also plays an important role in receptor dimerization and optimal activation. Mutations in the TM domain of EGFR family RTKs have been associated with increased breast cancer risk.	0.00213839
NZ_CP013126.1\|WP_015071183.1\|2134935_2136783_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP013126.1\|WP_015071185.1\|2132915_2133899_-\|type-I-pantothenate-kinase	gnl\|CDD\|235466	PRK05439, PRK05439, pantothenate kinase; Provisional.	0
NZ_CP013126.1\|WP_015071191.1\|2127620_2128031_+\|YccF-domain-containing-protein	gnl\|CDD\|236975	PRK11770, PRK11770, YccF domain-containing protein.	1.32844e-47
NZ_CP013126.1\|WP_028700962.1\|2117020_2117641_-\|superoxide-dismutase	gnl\|CDD\|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	1.75462e-90
NZ_CP013126.1\|WP_071162058.1\|2117772_2118615_-\|ECF-transporter-S-component	gnl\|CDD\|378961	pfam12822, ECF_trnsprt, ECF transporter, substrate-specific component. Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.	3.40359e-06
NZ_CP013126.1\|WP_028700960.1\|2120320_2121634_-\|ABC-transporter-permease	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	9.64014e-11
NZ_CP013126.1\|WP_015071190.1\|2128409_2128853_+\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	8.53986e-96
NZ_CP013126.1\|WP_028700963.1\|2116152_2116842_-\|glutamine-amidotransferase	gnl\|CDD\|235919	PRK07053, PRK07053, glutamine amidotransferase; Provisional.	4.48433e-95
NZ_CP013126.1\|WP_028700957.1\|2123221_2124112_-\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|211337	cd02570, PseudoU_synth_EcTruA, Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1). Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E. coli TruA makes psi38/39 and/or 40 in tRNA. psi38 and psi39 in tRNAs are highly phylogenetically conserved. P. aeruginosa truA is required for induction of type III secretory genes and may act through modifying tRNAs critical for the expression of type III genes or their regulators.	6.18598e-97
NZ_CP013126.1\|WP_028700958.1\|2122618_2123209_-\|methyltransferase	gnl\|CDD\|225370	COG2813, RsmC, 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis].	6.69992e-32
NZ_CP013126.1\|WP_036937246.1\|2124108_2124813_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	2.42636e-71
NZ_CP013126.1\|WP_028700964.1\|2115504_2116152_+\|hypothetical-protein	gnl\|CDD\|366312	pfam00797, Acetyltransf_2, N-acetyltransferase. Arylamine N-acetyltransferase (NAT) is a cytosolic enzyme of approximately 30kDa. It facilitates the transfer of an acetyl group from Acetyl Coenzyme A on to a wide range of arylamine, N-hydroxyarylamines and hydrazines. Acetylation of these compounds generally results in inactivation. NAT is found in many species from Mycobacteria (M. tuberculosis, M. smegmatis etc) to man. It was the first enzyme to be observed to have polymorphic activity amongst human individuals. NAT is responsible for the inactivation of Isoniazid (a drug used to treat Tuberculosis) in humans. The NAT protein has also been shown to be involved in the breakdown of folic acid.	6.86684e-05
NZ_CP013126.1\|WP_028700954.1\|2130748_2132101_+\|phosphoglucosamine-mutase	gnl\|CDD\|237672	PRK14318, glmM, phosphoglucosamine mutase; Provisional.	0
NZ_CP013126.1\|WP_015071193.1\|2125027_2125513_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.13064e-20
NZ_CP013126.1\|WP_015071188.1\|2129804_2130521_-\|SDR-family-oxidoreductase	gnl\|CDD\|235914	PRK07041, PRK07041, SDR family oxidoreductase.	3.99905e-49
NZ_CP013126.1\|WP_015071189.1\|2128875_2129403_+\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	4.30772e-72
NZ_CP013126.1\|WP_015071184.1\|2133984_2134809_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	4.01577e-29

>NZ_CP013126.1|WP_036937246.1|2124108_2124813_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MRRSPRMNTSQEHAMARLGSRYLVDVPHDTTSTSVAPGSRLDPTEIFGRRAPLTVEIGSGSGDVLASVAAAHPERDFIGFEVYLPSVASSLTRLDHAGARNVRIIIADAAAGLEHLFGPGDLDELWTFFADPWHKKRHHKRRIVSPDLARLVASRLRPGGLWRLATDWQDYADWMLDVLTREPGLVPVDAGPEGYAPRWSERPITRYEKKGVAAGRTVRDLLYRNAREAEETAG
>NZ_CP013126.1|WP_028700957.1|2123221_2124112_-|tRNA-pseudouridine(38-40)-synthase-TruA
MSEVTRRWRLDIAYDGADFSGWAAQPDRRTVQGELERWIPRVLRLDPPVPLTVAGRTDAGVHARGQVAHIDLPAALEPRPDLARRLRRVLEPDVVVRRVSAVPDAFDARFSALWRRYVYRLWDADSDPDPLDRRHVVQVREHLDVDLLNAAGASLLGLRDFAPFCKRREGATTIRTLMDCRAVRLDDPAGTIELTVRADAFCHSMVRSLVGALAAVGASRRRQQWLDEVAASPTRASSVVVMPAAGLTLEEVGYPDEDGLAARAAQSRAVRSADELADCGCDGPDLPTTPTTHAAR
>NZ_CP013126.1|WP_028700958.1|2122618_2123209_-|methyltransferase
MSHYFQTPTGPVETRTIRARIWDEELTFTTAGGVFSGSRLDLGTSVLFRSVEPPSGPGTFLDLGCGYGPIACALALAVPGARVHAVDVNDLAVSLTDRNARSLGVGDRVRASRPEEVDPDLRFDEIWSNPPIRVGKETLHEMLLTWLGRLSADGVAHLVVGRNLGADSLARWLGGQGYAATRVASAKGFRVLDVTG
>NZ_CP013126.1|WP_028700959.1|2121642_2122296_-|hypothetical-protein
MHSPAHPLQRLAALFSALLLCAAMLASGAASASAQGLPAATPQDCLKAGNVWVYVTYSDGSVVANSCATDFGTGEAALKSAGVDVGKDAKGMICSLDKKPNPCPAKFNGQYWNYYTSTDGKTFTYSQKAADQSKPVKGSIEAWCYNKASEKSCTPKTLSLTAEVPDASSSTPSSSASPAASSDSGGSSSSTAWGVGIVAAVIVIGVVVYLVVRRRRN
>NZ_CP013126.1|WP_028700960.1|2120320_2121634_-|ABC-transporter-permease
MPRLLERPADPVITDDGAGRRPSPGAGPLEARPGRAGGTNRPARTAGGAPTHPVAWWAWALATGAAVSMTTSPLLIVLVIAALALVVANRRSDAPWARSAGTYITLALSVIIIRMVFQILLGGSDTGTVLVRLPRIPLPLGVTLGGPVTAEGLATTGYDALRLATMLACFGAANTLADPRGVLKSVPAALHDISVAVVIALSVFPQLIVSVARVRRARRLRGGRAKGLRALTSILIPVLQDAVESSMDLSRAMESRGFGRTRDNRRVRPGTATGLVASMCGLVIGVYLLLTDPRWASAPRLSAQLVGAVVLGLSAIGAVAGLRSSGRRLRVTRYRPHRWTPRSIAVIGCGLLVVICTAALNSLAPAAVNPSTSPLEWPVLHPLMLGIAALVAAPAFLTSPPRRARAAQPRQRDLPAQPRQRDLPAQPRPNHPDRRGR
>NZ_CP013126.1|WP_028700961.1|2118611_2120324_-|ABC-transporter-ATP-binding-protein
MTPAIRLDDVSITLPDAEAPVLSHLDLAVQEGDLALVIGRTGAGKSTLLGALNGLVPHFSGGRLEGTVTVAGRDTRGHRPRDLADVVGVVGQNPMAGFVTDTVEDEIAYGMEQLGISPSIMRKRVEETLDLLSIADLRSRPLLDLSGGQQQRVAIASVLAAQPRILVLDEPTSALDPTAAQDVLASITTLVDDVGLTVVLAEHRLERVMHAADTVIWLPGDGSAVQGDPSEVLLKADVTPPLAQLSRLLGWDSVPLSVRRARRRVHDEERIPARSAPEPSEALSWSADPDDDVAELEDLCVSYGDLDAVDHVDLALQSGTVTALMGRNGAGKSSLMWAVQGATRSSGSVRVRSNPAPAARPASGAQEWSDPRTASPEQARRLVSLVPQAAADLLYLPSVGDECEQADRESEVAPGTTASILDRLGAGLPADRDPRDLSEGQRLALVLAIQLAARPTVVLLDEPTRGLDYAMKAQLARIVRGIADGSGPGLPGSPAAVLISTHDVEFAAASSDRTVVMADGQIVADGTTRSVCTSSPAFSPQMAKVFHPADVLTPDEVARALKEPAEGGSR
>NZ_CP013126.1|WP_071162058.1|2117772_2118615_-|ECF-transporter-S-component
MRVTALATPTSSRIILVLTAVLGLLAFTWPLLLNPGTQADYESRAPFLLAGVLALGVVILLSDLGSAGIDAKALAMLGVLTACGAALRPLSAGTAGIEFIFLLIILGGRVFGAGMGFLLGATTFLTSAVLTAGFGPWLPYQMVAAGFVGLGAGLLPRLSGWAETVMLAGYGFVTAFGYGWLMDFAFWPFSLGLSTSISYSAQASIGTNLKHFVMFNIATSMVWNLGRALTNVVLITLLGQPIMRVLRRAARKASWGSRGGPATRSTPARPAVDLPATRPE
>NZ_CP013126.1|WP_028700962.1|2117020_2117641_-|superoxide-dismutase
MAVYTLPDLDYDYSALEPHISGQIMQLHHDKHHQTYVTGANTALEKLEEARAKGDFGAINKLEKDLAFNLGGHINHSVFWKNMSPDGGGRPEGNELAAAIDEYFGSFEGFQKQFNEAAKGLQGSGWGILAWDALGQRLNTFQLFDQQGNLPTSQIPIVQLDMWEHAYYLQYQNVKANYVDAWWNVVNWADATARFDRARTQTAGLI
>NZ_CP013126.1|WP_028700963.1|2116152_2116842_-|glutamine-amidotransferase
MPTAIALRHVHFEDLGVIEPVLRDAGYGLRYVDVADSPGAIARLDPDLLVSLGAPVGADDVARYPWLTAESELLRRRADAGAPVLGICLGAQLLALAMGGHLVSGGSTEIGYAPIELTESGQESPLRHLEGVPVLHWHGDRFTTPPDAVRLAATRIDPDQAFSQGPTVLGLQFHVEADPGHIERWLIGHAHEMASVGVDPDRVRQDALLHGERLTAAARAMARDWLAGL
>NZ_CP013126.1|WP_028700964.1|2115504_2116152_+|hypothetical-protein
MKRSLLVLAASAAAVVGPVIMAAPGPHPAGQTVQGRDGRRRRIDSIDDVVAAVEESGAQGWELVNLATGIVHRMYTHYSTWHLWLTPAQSARRGQGHSQQYNLALGAVLRRLGVDVETVHAARVRMEHHPWYHTGHTWLRVTVGGKTLDVCASRPGNRAGEVGFLPVTEVRPLGPLTRLDSALALTPFVVTSVWKTWLTGRGVQRWLYRPFGQSA
>NZ_CP013126.1|WP_015071193.1|2125027_2125513_-|MarR-family-transcriptional-regulator
MGPECAPTQGPDDPSAPPDEDFTSRFTTAISRISRRIRVTSFTMTYGALSALATIDRSGPLRPAELADIERVTRPSITRIVAALESRGYISRTDDPDDGRAFVVAITSSGRTALKQARTERAGDIACLMEGLTDPQLEALHQALPALERIARNASTGTERR
>NZ_CP013126.1|WP_015071191.1|2127620_2128031_+|YccF-domain-containing-protein
MRTLLNIIWLFLGGIWLGLGYLVAGVLACILVVTIPVGLASFRMARYVLWPFGSAVVRRPGAGAGSALMNLVWFVIAGWWLALLHVIAAAAQSITVVGIANAVVSLKMIPVSLFPFGRMIVPRGSLAPGERPLHSV
>NZ_CP013126.1|WP_015071190.1|2128409_2128853_+|50S-ribosomal-protein-L13
MTTYSPKPGEVTRNWYVIDAEDIVLGRLATTAANLLRGKHKPQYAPHIDTGDFVVVVNASKIAVTGNKATKSLRHDHSGRPGGLRTTTIGELLAKNPRRAVERAVWGMMPKNKLSRQQMSKLKVYGGPEHPHAAQKPQPFEITQIAQ
>NZ_CP013126.1|WP_015071189.1|2128875_2129403_+|30S-ribosomal-protein-S9
MTETTNHDENLESEVKPFTEGEREIAYRTDSNPSVAAGEAVRPAVVAPGAATGRRKEAIARVRIVPGSGKWSINGGRTLEDYFPNKVHQQIASEPFATAGVEGSYDVIVRITGGGVTGQAGALRLGIARALNAIDAEASRPALKKAGMLTRDARIKERKKAGLKKARKAPQYSKR
>NZ_CP013126.1|WP_015071188.1|2129804_2130521_-|SDR-family-oxidoreductase
MSTDLTGQRVLVIGGSRDLGLAVARAAASAGAVVIIGARDEQKASDAAASIQNAEWVRMDITDEASVEAGLAGAGKIDHIVILTAAHHNVPVDRLDHDRTVTAFEAKVIGPLMVAKHAAAVLAPTGSIVLFSGVAAWNPQKGFSVMGITNGAVSFAASHLAKELAPIRVNAISPGIIDSGSWDGMGANKQKFLQEAAGGNLVGRWGASSDIADAVVWLLSATFVSGETIHVEGGARHY
>NZ_CP013126.1|WP_028700954.1|2130748_2132101_+|phosphoglucosamine-mutase
MARLFGTDGVRGVANQDLTAELALDLSVAAAHVLGEAGAFGHRQPTALVARDPRASGEFLEAAVCAGLASAGVDVMRVGVIPTPAAAYLVNEYRTDLGVMLSASHNPMPDNGIKFFQRGGVKLADDLEDAIEARMEEPWQRPTGERVGRIRTSTDAVKTYIDHLVASLRQDKTLSGLKVVLDCANGASSKTGPTAFREQGADVTAIHASPDGININDACGSTHPEKLQAKVVELGADLGLAFDGDADRCLAVDHEGNIVDGDQVLAILALGLQEDHRLASNTVVATIMSNLGLTLAMKEHDIHVDQTKVGDRYVLESMNANGFSLGGEQSGHVIMSEFATTGDGVLTGLHVAARVARTGKTLKDLASVMKRLPQSLVNVRGVDKLRAGMDPEVNRAVADANQKLGETGRVVLRPSGTEPLVRVMVEAATQKEADKICHDLATIVKQRLAI
>NZ_CP013126.1|WP_051281809.1|2132107_2132887_+|hypothetical-protein
MGLFIRLRPDPDLGSLDTRSADRVRDLVRSSLDALGIEASVDGGHIDSSLGYLSLEPVARECADQDRGSWPVIVDEVVKRMVRSLVDGADQLSDATIGQHVVWRLLPDAERMGRSFRYVRPVQGADGAVPGVSVALAWDGEETLDVLNDAALSEVRDLDVAFRAGRENLVEDLAAAPVETTELAEGVVEISSPSWLTASWALLPEEVAARFLPGGAPVLLAAPDHRHLLVGPDAEAARTVLGQAAGETPVLPVVRRPSR
>NZ_CP013126.1|WP_015071185.1|2132915_2133899_-|type-I-pantothenate-kinase
MDLTPIPPADDDNTEAGPYIELSRAAFADLAERTDIDIDEEALERIRGLGDPTSQRDVVEIYRPLTQLIHLYCMHTGALFEASDAFLRLGDHGMRRTPFVIGIAGSVAVGKSTVARLLKELLARSPRRPEVELITTDGFLYPNSVLEEKGLLERKGFPESYDRKALLQFVVDVKSGVPEVAAPVYSHISYDIVPDEKVVVRHPDILIVEGLNVLQPPRLRSNNTTGLTLSDFFDFSVYVDAREDDIIDWYLSRFLALRRTAFTDPDSYFTEYAALPDDQAVAVAREIWDQINGPNLRHNVLPTRGRATAILHKGHDHEIESIWIRKI
>NZ_CP013126.1|WP_015071184.1|2133984_2134809_-|methyltransferase-domain-containing-protein
MKTSQSYTETGYTHGHSAPVLAAHATRSAATSAGYLLPELEPGMSLLDIGCGPGTVALDLAERVRPGRVVGVDPSLEALEAARDEASRRGDRTTDFMAADVAELPFADASFDVVHAHQVLQHLQDPVGALREMARVSASLVAVRDVEYRTMSWYPDIPGLDMWLDTYRAIARANAAEPDAGRHLKSWARAAGLEDLQVTASTWCYTDPESVHWWSTSQAARVAGQTFTRQAVEIGRSRADVEEMRRAWLDWGASPDAYFAMVHTELLARVPARR
>NZ_CP013126.1|WP_015071183.1|2134935_2136783_+|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYCGHQQAEHVIIEGLRRLEYRGYDSAGLAVVADGSLHWAKKSGKLANLVSELESHRLPESTQGIGHTRWATHGAPTDANAHPHLSADGKVAVVHNGIIENFATLKAELIAEGVTFVSDTDTEVAAHLIGRETAKGAGLAEAMGRVASRLAGAFTLVAVSADEPDVVVAARRNSPLVVGLGEGENFLASDVAAFIEHTRDALELGQDQVVTITPESVTVTDFEGRPSEARPYHVDWDLSAAEKQGHDWFMRKEIFEQPKAVADTLLGRWSDRGELVLDELRISPEELRRINKIVIVACGSSFYAGMVAKYAIEHWTRVACEVELASEFRYRDPIIDPMTLVVTISQSGETADTLMAIRHAREQQARVIAICNTNGATIPRESDAVIYTHAGPEIGVASTKGFLTQVVACYLLGLYLAQVRGMKYGDEVHAIVDELNSMPDKIQAVLDGIEPVYKLARKMAMSEDAVFFLGRHVGYPVALEGALKLKEIAYLHAEGFAAGELKHGPIAVIEQDTPVFVVVPPEGRDQLHDKVVSNIEEIRARGARTIVLAEEGDAAAESFADMVIPLPKCSTLLQPLVAAVPLQAFACELATAKGHDVDQPRNLAKSVTVE

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Crispr_ID: NZ_CP013126_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013126_9

2536168-2536277

Orphan

Consensus_repeat	Method
CGCCAGGGGGTGCAGGGGGGTTGCCCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013126_9

>merge|NZ_CP013126|9|2536168-2536277|CRISPRCasFinder
CGCCAGGGGGTGCAGGGGGGTTGCCCCCCCCTGGGGTGCGCTGTCCGGCCTGCGACGCGGTCGTGGGATCTGCGAGGTTGCCGCCAGGGGGTGCAGGGGGGTTGCCCCCC

>NZ_CP013126|9|9|2536168-2536277|CRISPRCasFinder
CGCCAGGGGGTGCAGGGGGGTTGCCCCCC	CCTGGGGTGCGCTGTCCGGCCTGCGACGCGGTCGTGGGATCTGCGAGGTTGC
CGCCAGGGGGTGCAGGGGGGTTGCCCCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013126.1\|WP_028701372.1\|2548123_2549122_+\|HAD-IIA-family-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP013126.1\|WP_051282148.1\|2527668_2528784_-\|IS630-family-transposase	unknown	unknown	gnl\|CDD\|315923
NZ_CP013126.1\|WP_028701850.1\|2523622_2524339_+\|L-ribulose-5-phosphate-4-epimerase	unknown	unknown	gnl\|CDD\|235829
NZ_CP013126.1\|WP_036938780.1\|2524398_2525910_+\|L-arabinose-isomerase	unknown	unknown	gnl\|CDD\|179503
NZ_CP013126.1\|WP_028701841.1\|2534871_2536167_+\|citrate-synthase	unknown	unknown	gnl\|CDD\|99867
NZ_CP013126.1\|WP_028701840.1\|2536280_2537240_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|223739
NZ_CP013126.1\|WP_028701845.1\|2531032_2531587_-\|antirestriction-protein-ArdA	unknown	unknown	gnl\|CDD\|377800
NZ_CP013126.1\|WP_028701848.1\|2526035_2527049_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380488
NZ_CP013126.1\|WP_028701844.1\|2531724_2531922_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP013126.1\|WP_015070790.1\|2537321_2537903_+\|DUF3090-domain-containing-protein	unknown	unknown	gnl\|CDD\|378626
NZ_CP013126.1\|WP_028701371.1\|2547423_2548131_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236983
NZ_CP013126.1\|WP_028701846.1\|2529933_2530935_-\|IS481-family-transposase	unknown	unknown	gnl\|CDD\|372671
NZ_CP013126.1\|WP_028701839.1\|2538032_2538704_+\|nicotinamide-mononucleotide-transporter	unknown	unknown	gnl\|CDD\|377432
NZ_CP013126.1\|WP_028701837.1\|2540506_2540989_+\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787
NZ_CP013126.1\|WP_154662090.1\|2529070_2529589_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_015070787.1\|2539039_2539900_+\|ATP-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234781
NZ_CP013126.1\|WP_015070788.1\|2538761_2539028_+\|phosphoribosyl-ATP-diphosphatase	unknown	unknown	gnl\|CDD\|212154
NZ_CP013126.1\|WP_051281980.1\|2549255_2549876_+\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|224187
NZ_CP013126.1\|WP_015070786.1\|2539948_2540470_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_028701842.1\|2533514_2534867_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|181163

Protein	Function_ID	Function_description	E-value
NZ_CP013126.1\|WP_028701372.1\|2548123_2549122_+\|HAD-IIA-family-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.12177e-81
NZ_CP013126.1\|WP_051282148.1\|2527668_2528784_-\|IS630-family-transposase	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.25008e-14
NZ_CP013126.1\|WP_028701850.1\|2523622_2524339_+\|L-ribulose-5-phosphate-4-epimerase	gnl\|CDD\|235829	PRK06557, PRK06557, L-ribulose-5-phosphate 4-epimerase; Validated.	4.40997e-147
NZ_CP013126.1\|WP_036938780.1\|2524398_2525910_+\|L-arabinose-isomerase	gnl\|CDD\|179503	PRK02929, PRK02929, L-arabinose isomerase; Provisional.	0
NZ_CP013126.1\|WP_015070790.1\|2537321_2537903_+\|DUF3090-domain-containing-protein	gnl\|CDD\|378626	pfam11290, DUF3090, Protein of unknown function (DUF3090). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.47393e-71
NZ_CP013126.1\|WP_028701840.1\|2536280_2537240_-\|aldo/keto-reductase	gnl\|CDD\|223739	COG0667, Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion].	8.05385e-98
NZ_CP013126.1\|WP_028701845.1\|2531032_2531587_-\|antirestriction-protein-ArdA	gnl\|CDD\|377800	pfam07275, ArdA, Antirestriction protein (ArdA). This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.	1.79564e-27
NZ_CP013126.1\|WP_028701848.1\|2526035_2527049_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380488	cd01574, PBP1_LacI, ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of LacI is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	4.01771e-112
NZ_CP013126.1\|WP_028701844.1\|2531724_2531922_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.60495e-07
NZ_CP013126.1\|WP_028701841.1\|2534871_2536167_+\|citrate-synthase	gnl\|CDD\|99867	cd06114, EcCS_like, Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS reaction is thought to proceed through three partial reactions and involves both closed and open conformational forms of the enzyme: a) the carbanion or equivalent is generated from AcCoA by base abstraction of a proton, b) the nucleophilic attack of this carbanion on OAA to generate citryl-CoA, and c) the hydrolysis of citryl-CoA to produce citrate and CoA. There are two types of CSs: type I CS and type II CSs. Type I CSs are found in eukarya, gram-positive bacteria, archaea, and in some gram-negative bacteria and are homodimers with both subunits participating in the active site. Type II CSs are unique to gram-negative bacteria and are homohexamers of identical subunits (approximated as a trimer of dimers). Some type II CSs including EcCS are strongly and specifically inhibited by NADH through an allosteric mechanism. Included in this group is an NADH-insensitive type II Acetobacter acetii CS which has retained many of the residues used by EcCS for NADH binding.	0
NZ_CP013126.1\|WP_028701846.1\|2529933_2530935_-\|IS481-family-transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	4.18466e-22
NZ_CP013126.1\|WP_028701839.1\|2538032_2538704_+\|nicotinamide-mononucleotide-transporter	gnl\|CDD\|377432	pfam04973, NMN_transporter, Nicotinamide mononucleotide transporter. Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide.	1.12437e-42
NZ_CP013126.1\|WP_028701371.1\|2547423_2548131_+\|hypothetical-protein	gnl\|CDD\|236983	PRK11788, PRK11788, tetratricopeptide repeat protein; Provisional.	7.09734e-05
NZ_CP013126.1\|WP_015070787.1\|2539039_2539900_+\|ATP-phosphoribosyltransferase	gnl\|CDD\|234781	PRK00489, hisG, ATP phosphoribosyltransferase; Reviewed.	1.82391e-138
NZ_CP013126.1\|WP_015070788.1\|2538761_2539028_+\|phosphoribosyl-ATP-diphosphatase	gnl\|CDD\|212154	cd11547, NTP-PPase_HisE, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs. This family includes M. tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs. M. tuberculosis HisE is encoded by the hisE gene, which is a separate gene presenting in many bacteria and archaea but is fused to hisI in other bacteria, fungi and plants. HisE is responsible for the second step in the histidine-biosynthetic pathway. It can irreversibly hydrolyze phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate. HisE dimerizes into a four alpha-helix bundle, forming two inferred PRATP active sites on the outer faces. M. tuberculosis HisE has been found to be essential for growth in vitro, thus making it a potential drug target for tuberculosis.	3.12418e-40
NZ_CP013126.1\|WP_051281980.1\|2549255_2549876_+\|biotin-transporter-BioY	gnl\|CDD\|224187	COG1268, BioY, Uncharacterized conserved protein [General function prediction only].	4.29784e-27
NZ_CP013126.1\|WP_028701837.1\|2540506_2540989_+\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	1.85723e-13
NZ_CP013126.1\|WP_028701842.1\|2533514_2534867_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|181163	PRK07906, PRK07906, hypothetical protein; Provisional.	0

>NZ_CP013126.1|WP_028701841.1|2534871_2536167_+|citrate-synthase
MDQLVDETCTLTLDGHEYTLPVRTGSTGDRVIDISGLRAATGGVTTFDPSFANTSSCESSISWIDGENGRLTYRGIPIEILASEKVSFVEVAWLLIFGSLPTKVEREHFTELLTEYSSLHRSMDLHFNAFPPNGHPMAIMSSMINAMSTHDRPKITDEMSFTDSAAKLLSKVRTIAAASYKASIGEPAIYPRYDLKYVENFMHMMFSLPYRPFEADPIVARALNLFFVLHADHGQNCSTSTVRMVASSGANLFTSCSAGVCALWGPRHGGANVDAVQALQKIKDSGLTPRQYVARAKDNGERISGFGHRIYRNWDPRARILRGTCSQLLDSLNRTDPLLNIARELEDAVLSDDYFVERRLFPNVDFYSGIVLRALNIPLNMFTVMFAIGRMPGWIAHWREATSDPKGKIARPRDLYVGPDNTAWVPRSQRG
>NZ_CP013126.1|WP_028701842.1|2533514_2534867_+|M20/M25/M40-family-metallo-hydrolase
MDQPTDPEVRAADSPDAEVVPICQELVRIDSSNYGRHDARGETEVARLVAGLLSEIGVRSRIYESEPGRATLVAEWAPEGTDMSRPALLLHGHSDVVPAVADDWSIDPFSGELRDGCLWGRGALDMKGYLAMVLSAIRARHRRGQPPSRPIRFILFADEEGSGTLGSTWLGAHHPEAFDGVTEAISEVGGFSVTTPGGQRAYVVQAAEKGLWWFRMTATGSAGHGSMRNRDNAVSRLAEALGRISGYAWPDLHHPVQEEFLSRFEQLWGIGVDHDRLEESLAALGPLSRMVAACSANTVTPTVLSAGYKVNVIPTSASAELDARFIPGHEQEMIDTIKGLAGPGIEFETISHKPSAEAPFEGPAVDAIRSALAVEDPGAVVLPYLNSAGTDAKGFARLPDGRVINCYGCTPLRLPPDFDFISLFHGVDERVPLDTLAFGARVVDHILQEA
>NZ_CP013126.1|WP_028701844.1|2531724_2531922_-|helix-turn-helix-transcriptional-regulator
MSRRPNPAKGIGKDIRDARKSQHRLASEAGISRPTIARVETGSNISTGTLEKVAKALGKRLRIDA
>NZ_CP013126.1|WP_028701845.1|2531032_2531587_-|antirestriction-protein-ArdA
MTTTSPQTTDTTPRAWLGCLSCYNAGRLVGDWFDAVDADAVTSYDIHGAHSRADSHDELWVFDHENLPVSGELDTVTAASWGRCLAEVDEHLRPALCAWIRSGDYVAEGNSDLPSIGDFEERYCGEWDSFREYAESPVDDVGLLDGVPEEIANYFDWTSWTRDLAMDYSTYPNPDGGVYVFRDL
>NZ_CP013126.1|WP_028701846.1|2529933_2530935_-|IS481-family-transposase
MTHANAPLTPEGRRRLAVLVVEQGWSLRRAAERFQCSPATVKRWADRYRAGLPLIDRSSRPTSSPNRLSRKTEHRIVALRFTRRWGPHRIAYHLRLHRSTVGRVLARYKMPKLINIDQATGLPVRRPKPTRYEVAAPGQLVHVDIKKQGRIPDGGGWRAHGRGSMQDRHAGVARDKAARAGAAGSRGYRYLHHAVDDHSRIAYSEILDDERKETAAGFWTRANAFFAGLGVTVTAVMTDNGSCYRSGAFADALGDHVKHKWTRPYRPQTNGKVERFNRTLAVEWAYAKPYASEAERAAAYETWLHHYNHHRPHTGIGGQTPSARVHNVTGKYT
>NZ_CP013126.1|WP_154662090.1|2529070_2529589_+|hypothetical-protein
MATSAVATSAQAAGSERATTEVNPVSVIAKAKHDSPKSLAEKVAILRKSDALMDLFVGSPDSRTTNTYLEFFAAISTIDQVRGFVEKTAGKHFVASGPDSNPTVTLEDGLPISARGSCCKCWKARVASIAYFAASGLTCAAVGAMTGAVGGFVCGGVFYAMESLPNFDAACK
>NZ_CP013126.1|WP_051282148.1|2527668_2528784_-|IS630-family-transposase
MASPRTEPVHLTDEERAVLEGWTRGRTLAAWRARRARIILELDGGATIGRAAELVGCSRTTVGKWRSRFAADRLDGLEDAPRPGRPRAVTDEAVQALVERTLHSKPTNGDRAWSTRSAAQASGMSQSMVSRVWRAFGLKPQAIDSWKLSTDPEFVDKVRDVVGLYMDPPADALVLAVDEKTQIQALDRTAPILPVLPTSPAKASHDYVRHGTTSLFAALDIASGSVITEHHARHTAAQFIGFLTTIDKAVPQDLDLHLVLDNYATHKTAKVHTWLLRHPRFHLHFTPTYSSWLNLVERWFAELTCRKLHGSAHRSVTELKADIQAWINQWNHDPKPFIWTKTADQILSTLAAYCTILNHTNDQPETSDSGH
>NZ_CP013126.1|WP_028701848.1|2526035_2527049_+|LacI-family-DNA-binding-transcriptional-regulator
MSETSRPPGMMDVARLAGVSHQTVSRVLNNADSVRPATREKVRRAIAELGYRRNLSARALVTNRTRVIGVVVARGGYYGPGSTSSAIQTAARGRGYATIVASLRDGSPGELAAVVDMLTDHGVEGITAIAPQLGFVEGLRKVARSVPIVVVADGFEVSEGMHPVSVDQRHGARLATQHLIGLGHRRIAHISGPDDWFDSRERVIGWRETLQDAGLEVPEVMVGDWSAESGYAMGGRLLEEGLPDAVFSSNDTMALGLLACLADLGIRVPDDISLVGYDDANGAAFFQPPLTTIRQPFEELGARCVEVLLEAIEGHEPEPQRIRPSLRVRRSCRRHQN
>NZ_CP013126.1|WP_036938780.1|2524398_2525910_+|L-arabinose-isomerase
MINNPFEAKEIWFFTGSQDLYGPEVLDQVAAQSKEIAAQIDGASTVPVKIVWKPVLKDREAIRTAALEANADDACVGVIAWMHTFSPAKMWILGMDALTKPLLQLHTQYAEKLPYATLDMDYMNLNQSAHGDREFGYLLTRLGKNRRIVVGHASHPDTALRIGTWARAATAWNALHHMKLARFGDNMRNVAVTEGDKTEAELRLGVSVNTWSVNDLVEVVDAVEESSIDELVATYDAQYDVAEELRPGGAARESLRYGARIELGLRKFLDDGGFEAFSTNFEDLGGLRQLPGLAVQRLMADGYGFGAEGDWKTAVLVRIAKIMGYGLDGGASLMEDYCYEFTPGKEKILGAHMLEICPSLTGKKPSLEIHPLDIGGREDPVRLVFDADPADGLVVALSDMRERFRLTANIVKIVGPDEPLPNLPVARAVWEPAPSFQTSTECWLTSGGAHHTVMTTNTDREMWEDLADIADIELALIDEDTTVRGFAKERLLETAIHRLNGGR
>NZ_CP013126.1|WP_028701850.1|2523622_2524339_+|L-ribulose-5-phosphate-4-epimerase
MTIHLSELDAGTRGLVAQTRQTVSDLHAELPRNNLVVWTAGNVSQRVPGTELFVIKPSGVSYDELTADAMVVCTLDGKKIDDGTPEHLQPSSDTAAHAYVYRHMPEVGGVVHTHSPYATAWAARREPVPCVLTMMGDEFGGEIPVGPFALIGDDSIGRGIVETLSHSNSRAVLMANHGPFTIGKDGRDAVKAAVMCEEVAKTVHFARQLGEPVPIPADDVAHLFDRYQNVYGQHDENA
>NZ_CP013126.1|WP_028701840.1|2536280_2537240_-|aldo/keto-reductase
MLARTVGASGLKVSRMGLGTLTWGGQTDTRDARTMLRSFVEAGGNLVDTAPAYGSGAAEKLIGRVIHSDLDRDDLVIATKAGFTVNGENRVVDTSRAAMLRDLEGSLRRLHTDHVDLWQVHAWGDAPLEETCDALDHAVRSGMARYVGVSNFVGWQSATAATWQRALRSRIPIISNQVEYSLLARRAEIEMMPSAHHHRMGVLAWSALGRGVLTGRYRTGTPKDSRGANDQLSWFVEPYLAAKSRAVVEAVAKAAQGLGVTTAQVALSWVRDAPQVASALVGARTPEQLDELLATDDEQLPAEITAALDDITGGANLMR
>NZ_CP013126.1|WP_015070790.1|2537321_2537903_+|DUF3090-domain-containing-protein
MARLTHRYLRPDRFVCGTVGRPGERTFFIQTRQDGQITSVRCDKEQLQVLTTHLARILDDLARLAAGGILVPGPVDEPVDDEPLDMPLEEEFTAGAIAIAWDSAAGRLVVEVFAISDDEMMEADPQLLLAASPQDAPDSLEVHLSPAQARDFVARGQLVISSGRPACPFCGQPISGSGHICPRANGYRRPLFL
>NZ_CP013126.1|WP_028701839.1|2538032_2538704_+|nicotinamide-mononucleotide-transporter
MGDVIMRFLNAQLDIGLGRPVLWREIIGNIFGLASALGGARRRIWAWPVGIVGNVLLFTVFLGGVFHTPQDLNLWGQAGRQVFFLITSAYGWVQWAAYRRSHRSSGGAAVAPRWATPKERMATAAAVVMLIVFYIVLKALGSWGPASDSWILTGSILATFGMARGWNEFWFIWIAVDLVGVPLLLSAHYYPSGLMYIFYGGFCLYGFFTWWRLRDQDRSVDIP
>NZ_CP013126.1|WP_015070788.1|2538761_2539028_+|phosphoribosyl-ATP-diphosphatase
MSKTFEELFAELSRKAAERPEGSGTVAELDRGVHAIGKKIVEEASEVWIAAEYEGNERTAEEISQELYHLQVMMVRLGIGLEDVYKYL
>NZ_CP013126.1|WP_015070787.1|2539039_2539900_+|ATP-phosphoribosyltransferase
MSGQNVLRIAVPNKGALSEAAASLLSEAGYRQRTDRKDLRLLDEANGVEFFYLRPRDIAIYVGEGTLDLGITGRDLLLDSMAQAVEVRGLGFGRSRFRFAAPAGRHNTVEGLAGRRIATSYPGLLRSYLDERGIDAHLIHLDGAVESSIGLGVADAIADVVETGTTLRKAGLEIFGEVILESEGVLIRRHGFEAGSAYEHFMKRIEGVQVARSYVMLDYDVPEANLAAASDLTPGLEAPTVSPLSRQGWYAVRAMVPRGQVQTLMDQLWDAGARAILSTDIAACRI
>NZ_CP013126.1|WP_015070786.1|2539948_2540470_-|hypothetical-protein
MADSTLTIIVSVVLIALPLLWGVLHWARRRSVRSMVRSIGLALVPAGLWILGVMGMVTQWGRQAVDWVRATTMDTTRWVGVAIAGVGVIAMITGSFIAPVTRQQARERRSGSRETTSGGSAKQVGPAKKPVQPPASKAAQKPGGKKQAGNPDKAGFTDEDRELMELLKERGID
>NZ_CP013126.1|WP_028701837.1|2540506_2540989_+|SseB-family-protein
MVSLLKPGGDLGDADEPTRAAMAAATTREGYLDAVVAMCSSRLLMPVMSPGASAPEGSTQVTELGAAVLTNERGESALLCFTGIDSLQAWDARARPVPGTLDDLAATVEEAGASSLLVDVAGPVPMVIGPDLVVQLSRGRRLVRLSDGYGWLEVTPGDRV
>NZ_CP013126.1|WP_028701371.1|2547423_2548131_+|hypothetical-protein
MDFDEKALPPSVKAELRGVPSDVAHIIEGHLVAAAELIDTDPELANKHAQAARRRAARLPVLREAAADTAYAAGEFASALNDYRTLRRMTGNDNYLPVMADCERALGRPQAALRLIKEAEEAGDLSSSQSVELVLVKAGARQDMGQDAEALRLLHSAVSGVHGSDEARARLYYAYAEALLRKGDTAAAREWFTSSDDLDASGLLDADERIARIDGVDLGDEDEQDDGEDPEDSDD
>NZ_CP013126.1|WP_028701372.1|2548123_2549122_+|HAD-IIA-family-hydrolase
MTEAVIDAYDAALFDLDGVIYLGPEAIPAAPATVEALLGRGIQVGFVTNNAARSTEVVAEQLNGMGIPVTRADVVSSAEAIAQLVAEQLPAGSPVLVAGAQALIDEVAGHGLRPVSSADDGPVAVIQGYDPQMTWPRLDECCIAIQRGARWYVSNPDSTRPTDRGLVPGAGAQMAVVATSVTGEPVMAGKPHRPLLDATVARLGCHRPIFVGDRLDTDILGANRAGMDSLLVLTGAHGGHDLLDAEPQFRPTRIARDLSGLLEPERRAVVEGGRAVCGHAEAQEVDGVVRITSAIGGDLDGQLDALAAVLALVWEGAARGEHDELDRLDLVH
>NZ_CP013126.1|WP_051281980.1|2549255_2549876_+|biotin-transporter-BioY
MADTTSPQASVKARAGGFQGTDLALIAVFAALVAVLSVIPPLFVVAAVPFALQMVAVMLTPLVLGAVRGGAALALYLVVGLLGLPVFAGQSSGPGVLLGATGGFLIGYIVAALAAGALATAVLRRRPRKPVLAVQLYLVALVDLVVVYAFGIAGMMINASLSLPAALAANGLFMVGDLVKALLAVAIAVAVLTAFPRLMPAVRAPR

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Crispr_ID: NZ_CP013126_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013126_10

3313321-3313412

Orphan

Consensus_repeat	Method
CGAAGCGACGTGGAGGGGTCCTCCCC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP013126_10

>merge|NZ_CP013126|10|3313321-3313412|CRISPRCasFinder
CGAAGCGACGTGGAGGGGTCCTCCCCGGATGCGACCGCTGACCCGACCCGCGCGGGGAGGCAGGAGCGAAGCGACGTGGAGGGGTCGTCCCC

>NZ_CP013126|10|10|3313321-3313412|CRISPRCasFinder
CGAAGCGACGTGGAGGGGTCCTCCCC	GGATGCGACCGCTGACCCGACCCGCGCGGGGAGGCAGGAG
CGAAGCGACGTGGAGGGGTCGTCCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013126.1\|WP_015069980.1\|3307227_3307917_-\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|238317
NZ_CP013126.1\|WP_015069967.1\|3321470_3321746_+\|Lrp/AsnC-ligand-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366431
NZ_CP013126.1\|WP_028701690.1\|3321813_3322392_-\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|366759
NZ_CP013126.1\|WP_015069965.1\|3322538_3323051_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223725
NZ_CP013126.1\|WP_051282098.1\|3318265_3319387_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NZ_CP013126.1\|WP_148279620.1\|3313421_3314057_-\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP013126.1\|WP_071162015.1\|3301497_3302712_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_028701693.1\|3314259_3315486_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|226951
NZ_CP013126.1\|WP_028701697.1\|3308064_3308478_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_028701692.1\|3316320_3317091_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP013126.1\|WP_051143638.1\|3302998_3305200_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226482
NZ_CP013126.1\|WP_015069982.1\|3305126_3306044_-\|methylenetetrahydrofolate-reductase	unknown	unknown	gnl\|CDD\|273212
NZ_CP013126.1\|WP_051282097.1\|3319638_3321453_+\|DEDD-exonuclease-domain-containing-protein	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|236123
NZ_CP013126.1\|WP_097959137.1\|3310176_3311124_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP013126.1\|WP_028701698.1\|3306105_3307206_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|173833
NZ_CP013126.1\|WP_015069972.1\|3315469_3316324_-\|phospholipid/glycerol-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP013126.1\|WP_015069970.1\|3317175_3318261_-\|ROK-family-glucokinase	unknown	unknown	gnl\|CDD\|273246
NZ_CP013126.1\|WP_028701696.1\|3308619_3310080_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP013126.1\|WP_028701694.1\|3311846_3313241_-\|3-deoxy-7-phosphoheptulonate-synthase-class-II	unknown	unknown	gnl\|CDD\|366662
NZ_CP013126.1\|WP_015069976.1\|3311125_3311773_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|225130

Protein	Function_ID	Function_description	E-value
NZ_CP013126.1\|WP_015069980.1\|3307227_3307917_-\|thiamine-phosphate-synthase	gnl\|CDD\|238317	cd00564, TMP_TenI, Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl) thiazole phosphate to yield thiamine phosphate. TenI is a enzymatically inactive regulatory protein involved in the regulation of several extracellular enzymes. This superfamily also contains other enzymatically inactive proteins with unknown functions.	6.8516e-35
NZ_CP013126.1\|WP_015069967.1\|3321470_3321746_+\|Lrp/AsnC-ligand-binding-domain-containing-protein	gnl\|CDD\|366431	pfam01037, AsnC_trans_reg, Lrp/AsnC ligand binding domain. The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold.	1.75817e-13
NZ_CP013126.1\|WP_028701690.1\|3321813_3322392_-\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|366759	pfam01694, Rhomboid, Rhomboid family. This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.	6.10179e-10
NZ_CP013126.1\|WP_015069965.1\|3322538_3323051_-\|peptidylprolyl-isomerase	gnl\|CDD\|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	1.14374e-68
NZ_CP013126.1\|WP_051282098.1\|3318265_3319387_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	2.66672e-33
NZ_CP013126.1\|WP_148279620.1\|3313421_3314057_-\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.98916e-57
NZ_CP013126.1\|WP_015069982.1\|3305126_3306044_-\|methylenetetrahydrofolate-reductase	gnl\|CDD\|273212	TIGR00676, 510-methylenetetrahydrofolate_reductase., 5,10-methylenetetrahydrofolate reductase, prokaryotic form. The enzyme activities methylenetetrahydrofolate reductase (EC 1.5.1.20) and 5,10-methylenetetrahydrofolate reductase (FADH) (EC 1.7.99.5) differ in that 1.5.1.20 (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while 1.7.99.5 (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as 1.5.1.20 and 1.7.99.5, this model describes the subset of proteins found in bacteria, and currently designated 1.7.99.5. This protein is an FAD-containing flavoprotein. [Amino acid biosynthesis, Aspartate family].	7.89656e-109
NZ_CP013126.1\|WP_028701693.1\|3314259_3315486_-\|ATP-binding-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.33084e-18
NZ_CP013126.1\|WP_028701692.1\|3316320_3317091_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	5.68538e-49
NZ_CP013126.1\|WP_051143638.1\|3302998_3305200_+\|AAA-family-ATPase	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	2.01203e-74
NZ_CP013126.1\|WP_051282097.1\|3319638_3321453_+\|DEDD-exonuclease-domain-containing-protein	gnl\|CDD\|236123	PRK07883, PRK07883, DEDD exonuclease domain-containing protein.	0
NZ_CP013126.1\|WP_097959137.1\|3310176_3311124_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	2.82549e-16
NZ_CP013126.1\|WP_028701698.1\|3306105_3307206_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	8.92543e-59
NZ_CP013126.1\|WP_015069972.1\|3315469_3316324_-\|phospholipid/glycerol-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	1.36584e-11
NZ_CP013126.1\|WP_015069970.1\|3317175_3318261_-\|ROK-family-glucokinase	gnl\|CDD\|273246	TIGR00744, Glucokinase_Glucose_kinase., ROK family protein (putative glucokinase). This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General].	1.16495e-87
NZ_CP013126.1\|WP_028701696.1\|3308619_3310080_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.82504e-104
NZ_CP013126.1\|WP_028701694.1\|3311846_3313241_-\|3-deoxy-7-phosphoheptulonate-synthase-class-II	gnl\|CDD\|366662	pfam01474, DAHP_synth_2, Class-II DAHP synthetase family. Members of this family are aldolase enzymes that catalyze the first step of the shikimate pathway.	0
NZ_CP013126.1\|WP_015069976.1\|3311125_3311773_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|225130	COG2220, COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only].	2.38233e-16

>NZ_CP013126.1|WP_028701694.1|3311846_3313241_-|3-deoxy-7-phosphoheptulonate-synthase-class-II
MLNGVPNLAELHAMPQMQQPSYPEPAAVADVVSRLRGLPPLVFAGECDDLRDKLAAVADGRGFLLQGGDCAETFAGVNADNIKGKLRVLLSMAVVMTYAAQVPVVKVGRIAGQYAKPRSKDTETRNGVTLPSYRGDAVNGFEFTPESRTHDPRRLLQIYNSSAATLNLVRAFVKGGFADLRGINAWNADFVRNSNVEARYEALAHEIESALAFMIACGVDDEQLSTVDFYASHEALLLDYEHAMTRIDSRSQLPYDTSGHLLWIGERTRQPDGAHVAFMRRVNNPLGIKLGPSTSGEDAVLTAELLDPDRIPGRITFITRMGAGNVREKLPPIIDAVESTGRKVVWTCDPMHGNTFESANGFKTRSFVDVCAEVNAFFDVHEEMGTWPGGVHVELTGDDVTECLGGVDALDEADLANRYETACDPRLNRNQSLELAFMIAERLSDGRLKRHAVSPLEPFRGMDM
>NZ_CP013126.1|WP_015069976.1|3311125_3311773_-|MBL-fold-metallo-hydrolase
MRITHLGHSCVLVEAADARILIDPGNFSDAWHGLTGLTAILVTHAHPDHVDPEHIEELVNANSGAICRAEKGAAAAVPQLDADPIMPGDIIEVGGARIEAVGGQHAVIHRDIPRIGNVGYLVGEGLGTILFHPGDELDETPHGVDVLACPAYGPWAAMKETVDFARAVGARDGFLIHDGLLNERGWRTAFDRHDEMTDTTFHDLRDGRPWEAPGR
>NZ_CP013126.1|WP_097959137.1|3310176_3311124_+|DMT-family-transporter
MVGFRSSRLAPAALMVMALLWGSTLVVMKDAYAHLSPTDLLANRFLVGALALGLLMPRAWRANARTIGKGLLLGLLFGAGQVLQAVGLSSTPASVNGFIGGLYVVVTPLLGAIFFGKRVPRQIWIAVALATVGLGSLALDPADLGAGIGVGELLTFAASVCFAAQIVALGRFATARNVASLALYQTIGAALVCAICAAPGGIRIASSGSEWFAVLYLGVVCSAAIAVLQSWAQARVEATRASVIMCTEPLWGAVFAIGLAGDPVTLRIILGGVSILAAMVMVVRPPRRRRGLTQDEAGPRQIEQAGIGDLVGDSK
>NZ_CP013126.1|WP_028701696.1|3308619_3310080_+|serine/threonine-protein-kinase
MSMTVSTDPLVGRVLGGRYEITSRIARGGMATVYRAQDTHLRRGVAVKVMHEGLYEDEEFARRFDLEAKAAARLVNPHVVSVFDQGVDDMRPYIVMEYVPGCTLRHVIVQEAPLTPRHALAMLEPVVSALASAHDDGLVHRDVKPENVLISDRGQIKVADFGLARAVTAQSATATGLLVGTVSYLPPELVVSNRADERSDVYSTGIVLFEMLTGHKPHTGDTPIQVAWAHVHEDVPAPSTYLAGDGRRGRELAEHIPAYLDALVRTCTARDPSDRPADGRVLLGLIRSARVSLAQGRADDPAITSLMHRGGGPRPTSPVPAPGAPTGSPARTRTPVSPIDRAGAVRPGAVATPRTDVSHRPDASHRAVSLRTPREAPNPTIRSAAPTRPRNPGAARTPRAGTVPTARVRSGRAPAPARTRNSYRGRRNLIAMLLITALAVTVGLLAYRFGVSLRTAASSVAVSGAAGSSSTTAAPLTGPEDPPSIR
>NZ_CP013126.1|WP_028701697.1|3308064_3308478_+|hypothetical-protein
MSIRKPIAAAITAVTILTGCSGHAQEAPSTPSADSDSRQVVTAYLKAAVGHDCQVTRSLTASSTWAWCDKPRMTAYKGIGSVVKLSAQEAGVALECYPMTVTTRDGQGRGLKEGTRPWTLCFQHTEAGYKLYQQGMR
>NZ_CP013126.1|WP_015069980.1|3307227_3307917_-|thiamine-phosphate-synthase
MTALLGLAARLQMSTLCLVTDLTPRAGELVDVVVSAVAGGVDMVQIRDTDADHEALAEGVAAIADALAGSQVLLGVHGVAATVEGTRADVLHLSAEGYPGPARTALGPHGLLGRSAHDVAQLERAAADCDYLFIGPVWSGPVRRQGGLELVGRAALDCRDHDDRPIPWFAAGGITAHNVGRVLEAGARRVAVGRAVTAASDPGEVARQISRAVGRAWLDDPLTGPVQPG
>NZ_CP013126.1|WP_028701698.1|3306105_3307206_+|polyprenyl-synthetase-family-protein
MSAPFDPADPAGDSFRQAVQSAITGFLVDQRPVLAGIGEELEPLRLAAVDYTGGGKRLRPAFSYWGAVAAAGQPVDAAPLLRAVSSLELLHVSALLHDDLMDHSDTRRGVPAAHRRFGAAHERAGGSGPAGDFGADMAILLGDLLLVWSMEMFTTSGIEPLRLAATGPLLEAVRTEVTCGQVLDVTAEAGMTGGGRESGLDLANRIVEYKTARYTVARPAQIGVSLAGGTADLQQAMLTFGSPLGRAFQFRDDLLGVFGDAQVTGKPAGDDIREGKRTTLVAHAIVASTPGDARALETLLGRHDLDDADIASARRIIEASGARAGVEADIERAYRQALDALGAASMTHEGRIALTELARQCVQRSS
>NZ_CP013126.1|WP_015069982.1|3305126_3306044_-|methylenetetrahydrofolate-reductase
MLSTTSPAETIAELLTRAERPLTSFEFMPPRSEEDVYRLWRATDELVPLRPDFISVTYGANGSRRDRTLRCTQHMVASGLRTVGHLTAVSQSVAELEQTVSDYHDAGVDHILAIRGDMPGGAAEPWVARPDGLANATELVRLVKRVNPGACVGVGAFPDCHPASGDLDLDARIVAEKAEAGASFAITQLFFIPEHYTDLVARVRALGCGIPIIPGIMPITSFSQIRRFGELSGTDVPADLVARLSEVAEDRAAVREIGLEAAARLSCRLLDEGAPGLHYYTLNRSRATTELHAMVRDRRPGLWDR
>NZ_CP013126.1|WP_051143638.1|3302998_3305200_+|AAA-family-ATPase
MASEQAHVDRVYAQLRSETEAAKRLARASQEIYHSDRTTWVREEDSTAMYERDAFAYNAARRLAVLDSEHEGLVFGRIDLSDDSEVRHIGRIGVRDADYEPLVIDWRAPAAEAFYRATSTSPMGVVRRRVLRCRDDRVIGIEDDLLDSTKNRDDLPIVGEGALMAALSRARDTRMHSIVATIQSEQDEAIRAPYQGVTTISGGPGTGKTVVALHRAAFLLYSHRARLENGGVLVVGPSSVFMNYIERVLPSLGEDSVTLRAMGELASDVLGLDSDRLDESAAATLKGSLRMIDVIAALAALPLTPDPASLSLRVTIKGEVLILDAKALARTRARILRRNRYNSARQIVETSLLDQLWSKVPPETLSGYELTREDFDEAITSQASYRMFMNAWWPPMTAEQALGRLADPQVVARVATGLSAEDQKVLADSIPTSVDGGRRDWSITDIALLDELVAILGPAPVDLTAEQPVFIEGGEVSELVTVADTLADTRTVDPDDDPQDTFAHVLVDEAQDITPMQWRMLRRRGPQASWTIVGDPAQSAYPFPEETASAVAELTGHAPSRTFRLSKNYRSPAEVFDLAAGVITTVHPDADLPEAVRSTGIRPILRTSSRASLSEDLAATVRTLAGQVEGTIGIICPPSLAQVARDLAAGPLADLSGRVIPLTAMQAKGLEYDAAVVVDPDDLVAEAPGGVRVLYVALTRPTQRLVVTDLSDPTSPAGDHAPWRAALSSHGTD
>NZ_CP013126.1|WP_071162015.1|3301497_3302712_+|hypothetical-protein
MEVRGEGLIALAASLRLARLGHRVTLVAADPAWRSRARRPLSGELPPVLEVPAAWRDLFGKSGRNMDAELARDGFALTEAPPVLHRMEKETLALPTERAAQIAAVRTHWSPDVARIWSHLLDRADEAWQARRALGLEYPVAGALRGGDLPRALAGRHLTDGCDDLPALLRAVVGHLGPVAGGTRAGRGGTPLLADLAVPRVFGRWQLTRLDDGSATTLQPLLDALDRRLGARGVEVAAGPPRRPDLVIDTEPPRRRFGHDRPFLAPTVRLTRSPDTAPGGRRAERGVEHSVDHTPAGPVLRWSWSEQGQRATLTHDHTRPVRRPDLGRAIDSTAAWRRRPPLQWIRDDGAPVLAASPAAHGGPEPWAQLLTGALAAYLSHERLTGQDVSPHNRAVGADGRLRRH
>NZ_CP013126.1|WP_148279620.1|3313421_3314057_-|response-regulator
MLVDDHPMWIDALGQDLTADGFDIVAVAHDGSECLRRARAAQPDVLVIDLKIPEPDGATCTQLLTTEFPRMHVLVISASGEREDVLRAAKAGACGYMVKSATRAELLDGVRRTAQGDAVFTPGLAGLVLGEFRRMAIQPGGEDDSRPRLTDREVEVLRRVAKGMAYREIAEELVVSHRTVQNHVQNVLRKLQLHNRVELTLYALENGIGPD
>NZ_CP013126.1|WP_028701693.1|3314259_3315486_-|ATP-binding-protein
MGTSTEQTDGRPEHDGHGGAPHFTPLSTARVQHIVTVLRWVFLAHAVLMTVVRWDTVAHPGWMLALLAVMLVWTAIVTVQSRLRGLRWRPVVAVDLAVSVLVTVTSRVVLGPGVPTAGFEGVGYYWVVCAPLAVALSYGGVAGALAALLMILPGAFGVGHGHLWAWSADLLLLASCWGAGRLMDQMRSLLAENQRSHAITARMAERERLGRIVHDGALQVLSMVEREGPELGERGVVLAGLAREQGAQLRRLLQSAAGESALEADPDSGTVDLVATIEDHGSESVTVSAMAGELLLPAETVHEIDAALQQVLSNVAQHAGPGAHCWILIEQEERTIVISVRDNGVGMSPEQADQASREGRMGISRSIIGRIHDVGGTSEMTSAPGHGVEWEFRVPLDEKGGRPPLNPS
>NZ_CP013126.1|WP_015069972.1|3315469_3316324_-|phospholipid/glycerol-acyltransferase
MSRLPRWTGGQVDLTGEPLPDGPVVVAVHHTRYDDAVVVRAALHAVRSPWLGLVTPTRAVPWGTSARSRALAALRAGRVIVVFPEGSTAPGRAIYKGDVEVAHLALEAGAPVVPALLAEDRSALQLGAPLDFSRHASIPHSRAVLRAVTDEVMEALSGLADLPYHDLPAAAARQEEVQARRERVRADRAGRAAARQKAALQRQEAKAEAAEEAADLAQAAISAREAARSQAREAALADRLRAAGIRPGVPDDGETDGGATPRTPDSAATDDRETDEGDTDGDQH
>NZ_CP013126.1|WP_028701692.1|3316320_3317091_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MWYQVFKVGLFGPGVRALWRPWVVGEENLPREGGAVVACNHISVLDPIIVAAMLDRQMTYPAKKELFQGDHGLWSKIVAWFLKAVDQVPLDRSGGKRSVEGMAPVLTRLGEGGLIGIFPEGTRSADGELYKGKTGVARMALHADVPVVPVALIGTEPVKGRFGIPTVRHPGVIIGEPLHFSELAGRQDEVAVLRWVTNEVMDAIQRLGGQQYVDVYGFRVKYGNLKGKDLSRWRRPRPGGTPAPAPRETDRAGEQR
>NZ_CP013126.1|WP_015069970.1|3317175_3318261_-|ROK-family-glucokinase
MLSVGIDIGGTKVAAGVVDEQGTILRRLKRPTPSHSPEAVENAIVESVAELSVGLGVGAVGIGAAGWVDTEQALVRFSPHLAWRNEPLRDRLATRISVPVLVDNDANAAAWAEYRFGAGQGSRVMVCLTLGTGIGGALVINGRMFRGRYGMAGEFGHMTVVPDGHWCPCGNRGCWEQYASGNSLVRDAKALIAEGSPRAQGLLDHVAGRDPDQLIGPDVTAAAVDGDATAIELIADVGTWLGKGMAGLGAALDPDLFVIGGGVSAAGELLLGPARTAFARNLTGRGFRPLAEIEHARFGPDAGLIGAADLARHSIAEPPGPARGFWPRRRHPRRTVRRRPILHTFTSGFGAPVEQGSEPRP
>NZ_CP013126.1|WP_051282098.1|3318265_3319387_-|C40-family-peptidase
MAQNRQAGSKTRGAEKGRRLGRGLAATALSSAIVVSGLVAGQTRAAAEPDTVSEAKSELAAIEAQSHKLDAQYTTAQANLDKAEKSLKSAEKDLVSQRAKVASMRKTLSALAANDYQNGNISLSAQMVTSGDAGQFLSRLTTMQNVSDRTKSRFQSFQSEQARLQTLEKQAASDRTTIKASRDSQAVLLKKTKAKEDDAKKVLASLTAQEQQKLAREQAAAAQSRANAASQNSRSEVRSDTSASPASPSGSSSNTSASGRAATAIAFAKSKIGGPYVYGGTGPTGYDCSGLMQAAWAAAGVSLPRTSQEQFGAGTSVSTSNLQPGDLVFYYSGPSHVGMYIGGGQIVHAANPSAGIKISSVGEMPITGARHVG
>NZ_CP013126.1|WP_051282097.1|3319638_3321453_+|DEDD-exonuclease-domain-containing-protein
MSSMTAQDLQPSFDDLGTPLFDVTFCVVDLETTGGSGDDEITEIGAVKVRGGEVLGELATLVRPGSHIRGSVQMLTGITDEMVADAPSIGSVLPSWLEFSRGCVLVAHNARFDIGFLRRACDAHDRPWPGNTVLDTLALARSCLGRDEVHDHKLGTLARYFTATTSPSHRALDDARATVDVMHGIIERVSGLGVTTLEDLLEVTHKVAPGRRARRTWADSLPESPGIYWFQADRPTAGQPPEVLYVGTSVNVRRRVRQYFTASETRRRMDEMVRVATGVDALACATTLEAGVRELRMIDAHSPRYNRRSRRQNAVNWVCLTDDRYPRLSVVRSTSRTDRTYWGPFTNRQEAADAGSLIAEFAGIRQCSGTPASHPHGCPLAEMGRCVAPCLTGGGDDPSTLAQALAASPTGSSPRPPSTDPYRGAVDRARQAMTVDVRPLIEAASTRIASLSRQERFEEAAALTSRARSCLRAGRRRARIASLADCAEIVAARPVDRTWEIHIVRHGRLAAAALSPAGQNPVPTIEAARATAETATAAAPGIPACTAEEAELVAEWLETPGVRLVDIDGSWDWPVHCAAEDRALSDAVALASGRITDQECGRTA
>NZ_CP013126.1|WP_015069967.1|3321470_3321746_+|Lrp/AsnC-ligand-binding-domain-containing-protein
MFNAIVLIQASSNRIPEVAQEVLALPGVSEVYSTAGHIDLIAMVRASTMEEVAEIIADRINKVEGVVDTDTHIALRTYSEHDLEAMFSIGD
>NZ_CP013126.1|WP_028701690.1|3321813_3322392_-|rhomboid-family-intramembrane-serine-protease
MAAATLVVAVLSNLVPLATWLAAGSSPVFDFQVWRPLLYGLTTGSILQGIINGVFLVLVGRSLEPILGSADFAAVYLLSGLGGATALSLTGVPASFSGAICGIFGILAATAVIKHLEHQDIRGDIILITLFVIWGILAGARDWTADIGAIVIGAVIGWVWARNRWATRGRSRIAYAVIAGVCLAALVVTWLT
>NZ_CP013126.1|WP_015069965.1|3322538_3323051_-|peptidylprolyl-isomerase
MASTATLHTNHGDIVLNLFGDQAPKTVKNFVGLADGTQEYTDPLTGQKTTGRFYDGLTFHRIIDGFMIQGGCPLGTGTGGPGYQFADEFHPDLHFSKPYLLAMANAGPGTNGSQFFITVAPTPHLNRRHTIFGEVADEASRKVVDEIAQVKTDRMDRPADPVVIETVEIA

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Crispr_ID: NZ_CP013126_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013126_11

3526577-3526687

Orphan

Consensus_repeat	Method
CTCCACGTCGCTGCGCTCCTGCCTCCCCGAGCGGGTCAGGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013126_11

>merge|NZ_CP013126|11|3526577-3526687|CRISPRCasFinder
CTCCACGTCGCTGCGCTCCTGCCTCCCCGAGCGGGTCAGGTCCGCGACCGCGTCCCACTCCCGACGGGACTCCACGTCGCTGCGCTCCTGCCTCCCCGAGCGGGTCAGGTC

>NZ_CP013126|11|11|3526577-3526687|CRISPRCasFinder
CTCCACGTCGCTGCGCTCCTGCCTCCCCGAGCGGGTCAGGTC	CGCGACCGCGTCCCACTCCCGACGGGA
CTCCACGTCGCTGCGCTCCTGCCTCCCCGAGCGGGTCAGGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013126.1\|WP_028701455.1\|3519015_3520287_+\|DNA-recombination-protein-RmuC	unknown	unknown	gnl\|CDD\|376878
NZ_CP013126.1\|WP_028701449.1\|3528772_3528973_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_015069778.1\|3525734_3526556_+\|isoprenyl-transferase	unknown	unknown	gnl\|CDD\|237825
NZ_CP013126.1\|WP_015069769.1\|3533800_3534190_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_028701453.1\|3521310_3522576_+\|exodeoxyribonuclease-VII-large-subunit	unknown	unknown	gnl\|CDD\|272979
NZ_CP013126.1\|WP_028701443.1\|3534186_3534636_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_051282015.1\|3524932_3525613_-\|hemolysin-III-family-protein	unknown	unknown	gnl\|CDD\|224191
NZ_CP013126.1\|WP_028701444.1\|3533162_3533792_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|234604
NZ_CP013126.1\|WP_015069782.1\|3522572_3522827_+\|exodeoxyribonuclease-VII-small-subunit	unknown	unknown	gnl\|CDD\|179195
NZ_CP013126.1\|WP_028701445.1\|3532393_3533071_+\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NZ_CP013126.1\|WP_028701450.1\|3526697_3528734_-\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|224250
NZ_CP013126.1\|WP_015069780.1\|3523410_3524775_-\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224787
NZ_CP013126.1\|WP_028701447.1\|3530058_3531093_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013126.1\|WP_028701452.1\|3522834_3523353_-\|DUF4245-domain-containing-protein	unknown	unknown	gnl\|CDD\|379430
NZ_CP013126.1\|WP_028701459.1\|3514619_3517010_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650
NZ_CP013126.1\|WP_015069774.1\|3529507_3530005_+\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NZ_CP013126.1\|WP_015069775.1\|3529022_3529463_+\|DUF4307-domain-containing-protein	unknown	unknown	gnl\|CDD\|379491
NZ_CP013126.1\|WP_028701446.1\|3531104_3532283_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP013126.1\|WP_036937985.1\|3520210_3521179_-\|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	unknown	unknown	gnl\|CDD\|234893
NZ_CP013126.1\|WP_028701456.1\|3517613_3518891_-\|M18-family-aminopeptidase	unknown	unknown	gnl\|CDD\|235073

Protein	Function_ID	Function_description	E-value
NZ_CP013126.1\|WP_028701455.1\|3519015_3520287_+\|DNA-recombination-protein-RmuC	gnl\|CDD\|376878	pfam02646, RmuC, RmuC family. This family contains several bacterial RmuC DNA recombination proteins. The function of the RMUC protein is unknown but it is suspected that it is either a structural protein that protects DNA against nuclease action, or is itself involved in DNA cleavage at the regions of DNA secondary structures.	1.2972e-113
NZ_CP013126.1\|WP_015069778.1\|3525734_3526556_+\|isoprenyl-transferase	gnl\|CDD\|237825	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional.	3.61711e-118
NZ_CP013126.1\|WP_028701453.1\|3521310_3522576_+\|exodeoxyribonuclease-VII-large-subunit	gnl\|CDD\|272979	TIGR00237, exodeoxyribonuclease_VII_large_subunit, exodeoxyribonuclease VII, large subunit. This family consist of exodeoxyribonuclease VII, large subunit XseA which catalyses exonucleolytic cleavage in either the 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. Exonuclease VII consists of one large subunit and four small subunits. [DNA metabolism, Degradation of DNA].	2.17334e-142
NZ_CP013126.1\|WP_051282015.1\|3524932_3525613_-\|hemolysin-III-family-protein	gnl\|CDD\|224191	COG1272, COG1272, Predicted membrane protein, hemolysin III homolog [General function prediction only].	5.05709e-45
NZ_CP013126.1\|WP_028701444.1\|3533162_3533792_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|234604	PRK00058, PRK00058, peptide-methionine (S)-S-oxide reductase MsrA.	9.01747e-104
NZ_CP013126.1\|WP_015069782.1\|3522572_3522827_+\|exodeoxyribonuclease-VII-small-subunit	gnl\|CDD\|179195	PRK00977, PRK00977, exodeoxyribonuclease VII small subunit; Provisional.	1.98944e-17
NZ_CP013126.1\|WP_028701445.1\|3532393_3533071_+\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	1.14033e-121
NZ_CP013126.1\|WP_028701450.1\|3526697_3528734_-\|thioredoxin-domain-containing-protein	gnl\|CDD\|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP013126.1\|WP_015069780.1\|3523410_3524775_-\|PhoH-family-protein	gnl\|CDD\|224787	COG1875, COG1875, NYN ribonuclease and ATPase of PhoH family domains [General function prediction only].	6.63752e-179
NZ_CP013126.1\|WP_028701452.1\|3522834_3523353_-\|DUF4245-domain-containing-protein	gnl\|CDD\|379430	pfam14030, DUF4245, Protein of unknown function (DUF4245). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 188 and 235 amino acids in length.	5.61397e-40
NZ_CP013126.1\|WP_028701459.1\|3514619_3517010_+\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	4.39358e-07
NZ_CP013126.1\|WP_015069774.1\|3529507_3530005_+\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	1.47607e-57
NZ_CP013126.1\|WP_015069775.1\|3529022_3529463_+\|DUF4307-domain-containing-protein	gnl\|CDD\|379491	pfam14155, DUF4307, Domain of unknown function (DUF4307). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	2.04323e-29
NZ_CP013126.1\|WP_028701446.1\|3531104_3532283_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	2.24023e-43
NZ_CP013126.1\|WP_036937985.1\|3520210_3521179_-\|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	gnl\|CDD\|234893	PRK01045, ispH, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed.	4.99818e-174
NZ_CP013126.1\|WP_028701456.1\|3517613_3518891_-\|M18-family-aminopeptidase	gnl\|CDD\|235073	PRK02813, PRK02813, putative aminopeptidase 2; Provisional.	0

>NZ_CP013126.1|WP_015069778.1|3525734_3526556_+|isoprenyl-transferase
MHPAEHYIAKAGELLDRLHPSGLLYNTYEARLLDQLDRTRLPQHVAVLADGNRRWARLNAPGEPLVAGYQAGSDKLQAFCHWCDGVGIPVVTLWVLSTDNLQRAETGELGPLLKIIESLVITLARNPRWRVQTVGDMGLLPDDMAASLAEARKATADHDGMHINVAIAYGGRHELRDAVRSLLAEEAAKGTSLEELSQSLEIDQIAEHLYTKGQPDPDLIIRTSGEQRLSGFLMWQSAHSEFYFCEALWPDFRKVDFLRALRSFTQRERRYGR
>NZ_CP013126.1|WP_051282015.1|3524932_3525613_-|hemolysin-III-family-protein
MKTVVPERRRLLAAPAEVEPAPRLRGWIHTVMAPLVLVTGLGLIIAGDSWGNRFAVAVWICTGLALFGNSAVYHRIPWAPRIKAVLRRIDHANIAVFIAGTYTPLAVSMLTGASRVVLLSVIWGCAAAGVVFRVLWTDAPRWLYTGLYIVMGWVALWWLPQFWRSGGAAVVILILAGGVCYTLGAVAYARRRPDPSPTWFGFHEVFHAGTALGAVCHAVAIGLAVI
>NZ_CP013126.1|WP_015069780.1|3523410_3524775_-|PhoH-family-protein
MPTHSDPSSRLRAAIPTPGRGRRTYVVDTSVLLSDPRALLNFAEHHVVLPIVVITELEAKRTHPELGYFARAALRILDRLRIENDGLQRPVPLNDEGGTLNVELNHSDPGCLPDGLRLGDNDTRILAVAANYRQAGHRVVLVTKDMPLRIKASAIGLEAEEYRHELARDTTWTGMVELEVSDEVIGRLYRDGSLALDGADGSPGADDLTVNSGLVLQGPSSTALARTMPDQTARLVRSDQEVFGIHGRSAEQRVALDLLLDPEVGIVSLGGRAGTGKSALALCAGLDAVLERQIYQKVLVFRPLYAVGGQELGYLPGNEGEKMAPWGQAVMDTLTSVTNSYVIDEVLERGMLEVLPLTHIRGRSLHDAFVIVDEAQSLERNVLLTVLSRIGQNSRVVLTHDVAQRDNLRVGRHDGVAAVVERLRGNPLFGHVTLTRSERSPIAALVTRMLEDLV
>NZ_CP013126.1|WP_028701452.1|3522834_3523353_-|DUF4245-domain-containing-protein
MLRSLAVILIPLLVIIWVFTRTPDEPQVDPVDWRPAVADARSGAGYPVLAPVEVPTDWKPVKARYVDRGGQWVGSTQAAGNRWELGFRSGDDIYMAVNQSDEPGKDAYIGSVTRSSHPDGTSTIDGQTWQRRVSQDGRTRSLVRAVGGSTAVVVADTGYPALESFAQTLRTS
>NZ_CP013126.1|WP_015069782.1|3522572_3522827_+|exodeoxyribonuclease-VII-small-subunit
MTEQPQETTSPEATTDPEIGYEQARDELVEVVRRLESGGTSLADTMTLWERGEKLAAICQTWLDGARRRIEEARSASEGGPEEA
>NZ_CP013126.1|WP_028701453.1|3521310_3522576_+|exodeoxyribonuclease-VII-large-subunit
MASSSTPPEQTRSLAWVVRAVKDWVERCGKVWVEAQVIELNRRSGPTQFLTLRDVEEEISVTATCHRRVLDAAGPVESGMTVTALLRPTVWSRTGRLSFECSEIRPSGEGRLLAQLERRRRLLEAEGLFDSRLHKPLPLLPRGIGLITGARSDAERDVIRNATLRWPAVRFVVRNTLVQGARAVEQIIGALAELDADPGVDVIVIARGGGSLEDLLPFSDETLVRAVHAARTPVVSAIGHEADSPILDLVADLRASTPTDAGKRIVPDVAEELAGLRDVTARIRQSVASRIATEQSWLDSVRSRPVMMDPAATLDIASERLGATLARLRLATDRALETESREIDHQLRSVRAMSPKATLDRGYAVLADADGASVGSVSATREDARLDVYLSDGALGVTVDAVRPGGPATPTTPSPQKGTKS
>NZ_CP013126.1|WP_036937985.1|3520210_3521179_-|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase
MPDAPRKLVLAAPRGYCAGVDRAVITVEKALESYGAPVYVRKQIVHNRHVVETLEERGAIFVDELDAVPDGALVVFSAHGVSPAVKSEAARRGLRTIDATCPLVTKVHHEARRFSQEGAQILLIGHAGHEEVEGTTGEAPQDITLVQSPSDVDGLELDPDRPVAWLSQTTLSVDETAETVQRLREKTPDLVDPPSDDICYATTNRQQGVKQIAAHCDLMIVVGSRNSSNTLRLVDVALEAGARAAHRVDDAGEVKDSWLDGVAEIGVTSGASVPERLVQEVVEHLQGRGWPAPEEEQLIEESLSFALPPQLRSRRTRSARAH
>NZ_CP013126.1|WP_028701455.1|3519015_3520287_+|DNA-recombination-protein-RmuC
MTSMTTSHFVVLFIGLAIGLVVGWLLAELRARSALAQATSRADVAEAHRQAAEERAELTAGDRDSLADRFRALSAEALNTQQLRADRAAERTATDTQRLLAPVSQALEKLEHRLGEVERERSAMTARLGQQVEMVNAAGEGLRKETASLVTALRKPQVRGAWGEVQLRRVVELAGMVEHCDFEVQSTTTASGKALRPDMTVRMAGGRCVHVDAKTPLSAFLDAAATDDPDERAAHMAHFARNVRGHIDDLSSKGYWRTEVDSPEFVVLFLPSDAFLQAALDQIPDLHEYASRHDIVLADPSVLIPMLRVIALAWRQEDVARSAAEVAALGRDLHDRLGTLSTHLDKLGRSLTGAVRSYNSAVGSLETRVLVSARRFETTGVTTATLPSPGTVTDAVRPLSAPELTSSDDSEAEEEARRTTTPR
>NZ_CP013126.1|WP_028701456.1|3517613_3518891_-|M18-family-aminopeptidase
MTSPARAHVDDVISFVESSPTSYHAAAELARRLEEAGFERLDETADWSGAASVEGRRFVVRDGAVIAWATPETIGPRAGFRIVGSHTDSPSFKLKPHATFTNLGWQQVGMEVYGGGLLNSWLDRDLGLAGRLVTLDGETHLVRTGPILRISQLAPHLDRTVNQDLTLDRQRHLMPILSVGRPDLDVEDLLCEEAGIDRSRLGFHDILAYPTERPAVIGPAGEFLASSRMDNLSSVHSSIAAMVDVEVGEDIAVMACFDHEEVGSSTRSGACGPFLEDVLVRIADGLGRRGDAYRAMIARSTCISSDAGHGVHPNYPEKFDPANHPLLGQGPLLKINANQRYATDGVGGALWQRVCRAADVPTQAFVSNNSVPCGSTIGPLTATRLGMLTVDVGLPLMSMHSTRELAGVADLSSLSTALGAFWAGA
>NZ_CP013126.1|WP_028701459.1|3514619_3517010_+|ABC-transporter-permease
MPHHLYLRYIRSDLRRNRAVTLCLALVLTLSAFLMAGGAIMMERLAGSVGQIFTVAKPPHFLQMHQGTINRPALQRFSVNHPEIEAWQICEMIGFDGQAISWQRTGDDAGGDLSASLIDNLFVTQNRQFDLLLDAGADTAPRPAAGEVRVPVAYQQQFGLRAGDRLRIRTGSGTTSLRITGFVRDAQMASSMSSAIRFLVSPADFQRLSASGGGIPESIVEYRLRDTAGIGNLQRDYEADPALPRNGQAVTLVMIRLVNMVSDGLVAIALVFASLLLIVIAMLNVRLLIRATLEDEIHEIATMRAIGLPARDISSLYGLRYGILTLAGCLVGGALAIPAVGAMTAPMRATFADPPITWITVAAPLLALTVVLGIVMWLCRATLRRVRRIDIVDALVHGSTGPRKGRRRGTAPRSRLAGARPGRLWARLALAELRDERGRWVLLPVVFGLTTVLVTVPANVLATFQSPRFVTYMGAPSSDMRADIGSAAASGEPADDAHARLRSQLAGDTRVSATHDYAQLLYQTYGEDGWETIRIEVGDYSHTTMVFLSGAAPSAGQIAVSALNADKYGLSVGDTISVRRDDRSRSLTVSGIYQDVTSGGYTAKMQGAITAGADRWTVYIDLDPGADPVSLARQYNAAVPGASVIPMLEYVTQTFSYATDALHTASLVTLWLGLAASALITALFLRLRLARSRAGLATLSSIGFPSTELRAQLWLKAVLAVTIGVAAGSIIAATLAGPAVSALLSGLGTGITRLTLLPNPWISYLAYPLLLLTAGALATWVTARQIRDGRPLRWLS
>NZ_CP013126.1|WP_028701450.1|3526697_3528734_-|thioredoxin-domain-containing-protein
MPNHLADATSPYLLSHAANPVDWFGWGSDAFDEARSRDLPLLISVGYSSCHWCHVMALESFSDPEVAEVVNEYFVPVKVDREENPEVDASLMQATLALTGSGGWPNTVFCTPDGRPFFAGTYFPPEPRDGQPAFVDVVRALGQAWQERRDEVVQQAGVITDQLRAMASAQEPDDGAATGMPTAQELLDAVSTDYDIVNGGFGGPTKFPTPTLIDALLVKGDPTSLDMAQNTCEHLVRGGIFDQVGGGFHRYSTDSQWTVPHFEKMLNDNGLLLGTMARCWRRTADHDPDRRALYDHAVRRTVDWLRREMTTEEGLLAASLDADSDDLAGHTHEGIFYLWNTQLLVDALGEEEAGWLRPLLHLGDQGNFEGDLSTLQMRGRLDWERINADLDRMLEYRALRSRPARDEKVVTAWNAMVIDSLVEAGMILREWSWVEWAGELADKLWRAHWQGGRLLRTSLHGRPGTGAVTEDHAHLGLALAGLAGATGRRVWLDRAVEVLDAAVDRFSEPDGGFADAAASDLVVAPARTLTDDANPSPTSAMVKALRRVGLMAGREDLVERADLASRRLARVVVGAPRYAGWALADHLISDDARRGLRPAAVVVVEEDAEPGELAAAAWRMAPSGSALMRGAAGTDGFAEWFDERGDEQGPTAYVCRGTVCFEPVTDYLELKDPLWRRV
>NZ_CP013126.1|WP_028701449.1|3528772_3528973_-|hypothetical-protein
MPVQLISPGILNLIVFLALAAFGVIAWFSIRHNIHGIDFDEVPSGPELKSGPDRGEEGSGETGPRQ
>NZ_CP013126.1|WP_015069775.1|3529022_3529463_+|DUF4307-domain-containing-protein
MSPVTHGATQPGGRRLSPQEQERLAQRYPQRRRRLWIPLACLAAALLVGWTVWSGLHHSAEPMRVQLFGYQVVDATRVDVTVDVHRSDPSVSGSCTLYALSHDNQRVGEAPLRISPAGDQDVRIRAHLKTFSRAVTAQLENCQASR
>NZ_CP013126.1|WP_015069774.1|3529507_3530005_+|transcription-elongation-factor-GreA
MPESQDTVWLTQEAYDKLTQELAHLKGEGRTEISKKIAEARSEGDLSENGGYHAAREEQGQAEARIIQLDHMLRNAQVGEKPAGSHKVVPGSKVTVCYFGDKSDTETFLLGSREMMGLDDSVDTPVYSPQSPLGAAVLDLEIGATASYSAPNGKTIEVTVLDVAG
>NZ_CP013126.1|WP_028701447.1|3530058_3531093_-|hypothetical-protein
MSATPDLSGILADLAAGRIDAAEASRRIDAANRQADDHDEKEAPAPGPEDGPAGRNGEESKQNEERADGGSARGDAGPRGFFDESWNRVPPEAREGLRSAWRRVAGAAESVVDAASGQSSPRSAQRGPAGSEAGPRDTVTRLSVRCVGRRVTIIGDPGTPGVQVEGKHNRRRIGDVVEITSEGRIAPDLSGLLKLRFPKDAEGLKDLGLGPELIIRMHPDLALEVELAGGALRLSGVPDVDSVRVTAAVADIADVHHIGEALFQAGGSTLAGPIDTGRSRIRVESGNLTVRLAAGANVAIRADARPGLISWPDGGASVDEYIVGNGAARMDMSTVMGRIAVRTA
>NZ_CP013126.1|WP_028701446.1|3531104_3532283_-|AI-2E-family-transporter
MTDRHTSDASGDETDDAIPRGLRTAAGWSWRVLIIAALVAVVAFALAEISEVSIPVAVALMLTAALWPLANFLSRHRVPRGLASGLCLLALIVVIGGIFTLVGAQIASQWPVLSEQSVASFKQVMQWLDKGPLHIGSDQIDAYIAQAEAWAKGSQSRIASWAAAAGSGVGRFLTGLIMALFATFFFIYQGGSIARSVSVLIPTGSRPRILDAARSGWVALVGYVRAAVIVAFVDGLGAGIGAAIIGSGVAVAIGALTFVLAFIPIAGALIAGVISVAVVLVTLGFVKAVIMLLIFVGVMELESHILQPFLLGKAVSIHPLAILLGIAIGSVLAGIVGALFAIPLVAFGVAFAKALAHRYSEDGQAEPDEKPDEEETGAEDDELKDEDADATS
>NZ_CP013126.1|WP_028701445.1|3532393_3533071_+|uracil-DNA-glycosylase
MTAQPLSQLVAEDWAEALAPVEPVIHEMGDFLRSELAAGHGYLPSGDRVLRAFSRPMSQVKVLIVGQDPYPTPGHAVGLSFSVERDVRPLPRSLQNIYAELQSDLGIPPCPHGDLTGWFEQGVLLLNRCLTVRPGKPASHRNKGWEKVTQLAIESLVARGGPLVAILWGRDAQTLEPMLGDIPVVKSPHPSPMSARYGFFGSRPFSRANELLEKQGAQPIEWRLE
>NZ_CP013126.1|WP_028701444.1|3533162_3533792_+|peptide-methionine-(S)-S-oxide-reductase-MsrA
MSGDKIIDPVHALPGRSTPFLAMPFRHRVLGAPLNSHFDNAQEIYLAFGCFWGAEKLYWQTEGVLMTAVGYMGGVTPNPTYDEVCTGRTGHAETVRVTFDPQVLPVEEVLRLFFENHDPTQGMRQGNDVGAQYRSAIWCTGSGQYIAATAIRGQYQGALLGEGYGQITTTIEMAEGHPFYPAEAEHQQYLEANPFGYCPVHATGVCLVR
>NZ_CP013126.1|WP_015069769.1|3533800_3534190_-|hypothetical-protein
MSLRTAEHMLVTSYDDEGRAQTSLEQLVAVDDGQVGYWLANDQGVRDRFPDDCVVSVRAATSRGKPVIEEPVIEGRASVLADGPDFDRVKAGIREKYPSRSWVSTAMDRTREIFGGRTPECVVLIHLLG
>NZ_CP013126.1|WP_028701443.1|3534186_3534636_-|hypothetical-protein
MMKAVKWVLIVLGAVCLGVGLYMVIRLSMDMRTIMGAANAGKSVDVLQNPMRTVWIVGAVALGAGALLGAGIGLPRRTLGSVRRETLEGAAAQRESAIRENALRRAGRPRPEAATGDGELPAGSDRPQLETSADPETDDEAGKDDGGAR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP013126_4	4.1\|680925\|28\|NZ_CP013126\|CRISPRCasFinder	680925-680952	28	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	69884-69911	4	0.857
NZ_CP013126_4	4.1\|680925\|28\|NZ_CP013126\|CRISPRCasFinder	680925-680952	28	NZ_CP049317	Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence	1097435-1097462	4	0.857
NZ_CP013126_4	4.1\|680925\|28\|NZ_CP013126\|CRISPRCasFinder	680925-680952	28	NZ_CP049157	Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence	545233-545260	4	0.857
NZ_CP013126_4	4.1\|680925\|28\|NZ_CP013126\|CRISPRCasFinder	680925-680952	28	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	1007900-1007927	4	0.857
NZ_CP013126_11	11.1\|3526619\|27\|NZ_CP013126\|CRISPRCasFinder	3526619-3526645	27	NZ_CP023713	Rhodococcus ruber strain YC-YT1 plasmid unnamed2, complete sequence	16077-16103	4	0.852
NZ_CP013126_4	4.1\|680925\|28\|NZ_CP013126\|CRISPRCasFinder	680925-680952	28	NZ_CP013526	Rhizobium phaseoli strain R744 plasmid pRphaR744d, complete sequence	758895-758922	5	0.821
NZ_CP013126_4	4.1\|680925\|28\|NZ_CP013126\|CRISPRCasFinder	680925-680952	28	NZ_CP039965	Pseudorhodobacter sp. S12M18 plasmid unnamed1, complete sequence	1478164-1478191	6	0.786
NZ_CP013126_4	4.1\|680925\|28\|NZ_CP013126\|CRISPRCasFinder	680925-680952	28	NZ_CP038257	Microbacterium sediminis strain YLB-01 plasmid unnamed, complete sequence	26145-26172	6	0.786
NZ_CP013126_1	1.1\|224018\|35\|NZ_CP013126\|CRISPRCasFinder	224018-224052	35	MK524530	Mycobacterium phage Pharaoh, complete genome	24249-24283	7	0.8
NZ_CP013126_5	5.1\|889997\|34\|NZ_CP013126\|CRISPRCasFinder	889997-890030	34	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	1256279-1256312	9	0.735
NZ_CP013126_5	5.1\|889997\|34\|NZ_CP013126\|CRISPRCasFinder	889997-890030	34	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	41834-41867	9	0.735

1. spacer 4.1|680925|28|NZ_CP013126|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 4, identity: 0.857

cggccatgcacggggcggcctcgcgctc	CRISPR spacer
aggccatgaacggcgcggcctcgcgcgc	Protospacer
 ******* **** ************ *

2. spacer 4.1|680925|28|NZ_CP013126|CRISPRCasFinder matches to NZ_CP049317 (Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence) position: , mismatch: 4, identity: 0.857

--cggccatgcacggggcggcctcgcgctc	CRISPR spacer
gacggc--tgcacgtggcggcctcgcgctt	Protospacer
  ****  ****** **************.

3. spacer 4.1|680925|28|NZ_CP013126|CRISPRCasFinder matches to NZ_CP049157 (Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence) position: , mismatch: 4, identity: 0.857

--cggccatgcacggggcggcctcgcgctc	CRISPR spacer
gacggc--tgcacgtggcggcctcgcgctt	Protospacer
  ****  ****** **************.

4. spacer 4.1|680925|28|NZ_CP013126|CRISPRCasFinder matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 4, identity: 0.857

cggccatgcacggggcggcctcg-cgctc	CRISPR spacer
cggccatgcgccgggcggcctcgatgct-	Protospacer
*********.* *********** .***

5. spacer 11.1|3526619|27|NZ_CP013126|CRISPRCasFinder matches to NZ_CP023713 (Rhodococcus ruber strain YC-YT1 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.852

cgcgaccgcgtcccactcccgacggga	CRISPR spacer
cgtgaccgcgtcccgctcccgaccgca	Protospacer
**.***********.******** * *

6. spacer 4.1|680925|28|NZ_CP013126|CRISPRCasFinder matches to NZ_CP013526 (Rhizobium phaseoli strain R744 plasmid pRphaR744d, complete sequence) position: , mismatch: 5, identity: 0.821

cggccatgcacggggcggcctcgcgctc	CRISPR spacer
cagagatgaacggggcggcctcacgctc	Protospacer
*.*  *** *************.*****

7. spacer 4.1|680925|28|NZ_CP013126|CRISPRCasFinder matches to NZ_CP039965 (Pseudorhodobacter sp. S12M18 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.786

cggccatgcacggggcggcctcgcgctc	CRISPR spacer
tcgccatgcacggggcggctttgcgcat	Protospacer
. *****************.*.**** .

8. spacer 4.1|680925|28|NZ_CP013126|CRISPRCasFinder matches to NZ_CP038257 (Microbacterium sediminis strain YLB-01 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.786

cggccatgcacggggcggcctcgcgctc	CRISPR spacer
cgtccatgcacggggcgccctcgtcgac	Protospacer
** ************** *****.   *

9. spacer 1.1|224018|35|NZ_CP013126|CRISPRCasFinder matches to MK524530 (Mycobacterium phage Pharaoh, complete genome) position: , mismatch: 7, identity: 0.8

aggtcg--caggaccacgatgagccgggagaggaggt	CRISPR spacer
--gttgatggggaccacgatgagcccggagaggatgt	Protospacer
  **.*   .*************** ******** **

10. spacer 5.1|889997|34|NZ_CP013126|CRISPRCasFinder matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 9, identity: 0.735

acgccgaacccggacgcagacccaacccgctcga	CRISPR spacer
aaccggaacccggacgcagactcgacccggcctg	Protospacer
*  * ****************.*.***** .* .

11. spacer 5.1|889997|34|NZ_CP013126|CRISPRCasFinder matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 9, identity: 0.735

acgccgaacccggacgcagacccaacccgctcga	CRISPR spacer
aaccggaacccggacgcagactcgacccggcctg	Protospacer
*  * ****************.*.***** .* .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

667265 : 694477

Mycobacterium_phage(10.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060539046.1\|667265_668591_-\|transposase	ISL3 family transposase	A0A2H4PDF8	Mycobacterium_phage	3.5e-192	76.0
WP_169792794.1\|668684_669197_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	1.4e-35	48.4
WP_154662081.1\|669226_669370_-	hypothetical protein	NA	NA	NA	NA
WP_002546835.1\|669397_669745_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_008598604.1\|669857_670280_+	arsenite efflux transporter metallochaperone ArsD	NA	NA	NA	NA
WP_028701538.1\|670308_672069_+	arsenical pump-driving ATPase	NA	NA	NA	NA
WP_028701537.1\|672142_672952_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.5e-33	34.5
WP_028701536.1\|672948_674616_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_015069156.1\|675023_675509_-	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_028701535.1\|675807_676995_+	2,3-diaminopropionate biosynthesis protein SbnA	A0A1W6JHY1	Lactococcus_phage	6.2e-31	33.2
WP_028701534.1\|677083_679069_+	FAD/NAD(P)-binding protein	NA	NA	NA	NA
WP_028701533.1\|679080_680790_+	diaminopimelate decarboxylase	NA	NA	NA	NA
WP_060539048.1\|681151_682411_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.6e-77	41.9
WP_015069150.1\|682915_685984_+	DUF4981 domain-containing protein	L0N6M2	Herpes_simplex_virus	3.6e-139	32.7
WP_015069149.1\|686006_687395_+	MFS transporter	NA	NA	NA	NA
WP_015069148.1\|687440_688436_+	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	2.7e-40	33.2
WP_036938199.1\|689954_691373_+\|transposase	IS30-like element ISPfr9 family transposase	W5R8L2	Staphylococcus_phage	1.0e-32	35.9
WP_028701541.1\|691522_692878_+	FAD-dependent oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	6.0e-91	42.6
WP_097959151.1\|693266_694477_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	1.9e-35	34.4

DBSCAN-SWA_2

978284 : 987180

Brucella_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_051281943.1\|978284_980087_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	4.6e-30	25.7
WP_028701328.1\|980598_982041_-	MFS transporter	A0A0M3UL24	Mycobacterium_phage	4.0e-32	28.6
WP_028701327.1\|982590_983802_+	RtcB family protein	A0A1I9SAD2	Rhodococcus_phage	3.2e-107	51.8
WP_028701326.1\|983939_984236_+	type II toxin-antitoxin system RelE/ParE family toxin	A0A141GEX6	Brucella_phage	5.8e-15	48.0
WP_028701325.1\|984232_984535_+	putative addiction module antidote protein	A0A141GEX5	Brucella_phage	2.9e-09	41.9
WP_015068915.1\|984623_984923_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_076692652.1\|984919_985276_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_015068914.1\|985406_986066_+	response regulator transcription factor	NA	NA	NA	NA
WP_051281955.1\|986523_987180_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.3e-34	42.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP013126

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection