CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP013220	Streptomyces hygroscopicus subsp. limoneus strain KCTC 1717 chromosome II	1 crisprs	NA	0	0	4	0
NZ_CP013219	Streptomyces hygroscopicus subsp. limoneus strain KCTC 1717 chromosome I	12 crisprs	csa3,casR,DEDDh,WYL,cas4,Cas9_archaeal,cas3,DinG	2	3	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP013220_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013220_1

636802-636887

Orphan

Consensus_repeat	Method
CCGACCACGACCAGGCTCCGCTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013220_1

>merge|NZ_CP013220|1|636802-636887|CRISPRCasFinder
CCGACCACGACCAGGCTCCGCTCCTCCCGCACACCCACCCGATGCGCCGACCCGCCGCAGGACCGACCACGACCAGGCTCCACTCC

>NZ_CP013220|1|1|636802-636887|CRISPRCasFinder
CCGACCACGACCAGGCTCCGCTCC	TCCCGCACACCCACCCGATGCGCCGACCCGCCGCAGGA
CCGACCACGACCAGGCTCCACTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013220.1\|WP_058084623.1\|644399_645248_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|272862
NZ_CP013220.1\|WP_058084615.1\|625981_628237_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP013220.1\|WP_014669115.1\|646226_646688_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|238329
NZ_CP013220.1\|WP_028799214.1\|629063_629267_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP013220.1\|WP_058084616.1\|631048_631354_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341358
NZ_CP013220.1\|WP_058084622.1\|643215_644142_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223999
NZ_CP013220.1\|WP_015493116.1\|641000_641576_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP013220.1\|WP_058084620.1\|637128_640188_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|197715
NZ_CP013220.1\|WP_058084621.1\|642682_643111_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176861
NZ_CP013220.1\|WP_107113041.1\|641727_641937_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153102
NZ_CP013220.1\|WP_058084618.1\|632871_633222_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379171
NZ_CP013220.1\|WP_079088355.1\|642024_642564_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227803
NZ_CP013220.1\|WP_058084614.1\|625413_625701_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013220.1\|WP_014669098.1\|640349_640784_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013220.1\|WP_058084617.1\|631416_631737_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013220.1\|WP_058084613.1\|624460_625387_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223999
NZ_CP013220.1\|WP_058084625.1\|646841_647603_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP013220.1\|WP_014669103.1\|631865_632240_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013220.1\|WP_058085378.1\|629593_630919_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_CP013220.1\|WP_058084619.1\|633916_636739_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197715

Protein	Function_ID	Function_description	E-value
NZ_CP013220.1\|WP_058084623.1\|644399_645248_-\|SAM-dependent-methyltransferase	gnl\|CDD\|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	2.23856e-79
NZ_CP013220.1\|WP_058084615.1\|625981_628237_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.63617e-09
NZ_CP013220.1\|WP_014669115.1\|646226_646688_-\|acyl-CoA-thioesterase	gnl\|CDD\|238329	cd00586, 4HBT, 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).	1.68946e-12
NZ_CP013220.1\|WP_028799214.1\|629063_629267_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	2.08861e-34
NZ_CP013220.1\|WP_058084616.1\|631048_631354_+\|hypothetical-protein	gnl\|CDD\|341358	cd02205, CBS_pair_SF, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	0.00830742
NZ_CP013220.1\|WP_058084622.1\|643215_644142_-\|alpha/beta-hydrolase	gnl\|CDD\|223999	COG1073, COG1073, Hydrolases of the alpha/beta superfamily [General function prediction only].	6.97745e-23
NZ_CP013220.1\|WP_058084620.1\|637128_640188_-\|AAA-family-ATPase	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	9.38676e-16
NZ_CP013220.1\|WP_058084621.1\|642682_643111_+\|hypothetical-protein	gnl\|CDD\|176861	cd07819, SRPBCC_2, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	3.80491e-05
NZ_CP013220.1\|WP_107113041.1\|641727_641937_+\|hypothetical-protein	gnl\|CDD\|153102	cd01043, DPS, DPS protein, ferritin-like diiron-binding domain. DPS (DNA Protecting protein under Starved conditions) domain is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. Some DPS proteins nonspecifically bind DNA, protecting it from cleavage caused by reactive oxygen species such as the hydroxyl radicals produced during oxidation of Fe(II) by hydrogen peroxide. These proteins assemble into dodecameric structures, some form DPS-DNA co-crystalline complexes, and possess iron and H2O2 detoxification capabilities. Expression of DPS is induced by oxidative or nutritional stress, including metal ion starvation. Members of the DPS family are homopolymers formed by 12 four-helix bundle subunits that assemble with 23 symmetry into a hollow shell. The DPS ferroxidase site is unusual in that it is not located in a four-helix bundle as in ferritin, but is shared by 2-fold symmetry-related subunits providing the iron ligands. Many DPS sequences (e.g., E. coli) display an N-terminal extension of variable length that contains two or three positively charged lysine residues that extends into the solvent and is thought to play an important role in the stabilization of the complex with DNA. DPS Listeria Flp, Bacillus anthracis Dlp-1 and Dlp-2, and Helicobacter pylori HP-NAP which lack the N-terminal extension, do not bind DNA. DPS proteins from Helicobacter pylori, Treponema pallidum, and Borrelia burgdorferi are highly immunogenic.	1.32613e-17
NZ_CP013220.1\|WP_058084618.1\|632871_633222_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|379171	pfam13411, MerR_1, MerR HTH family regulatory protein.	7.49248e-09
NZ_CP013220.1\|WP_079088355.1\|642024_642564_-\|hypothetical-protein	gnl\|CDD\|227803	COG5516, COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only].	5.49156e-21
NZ_CP013220.1\|WP_015493116.1\|641000_641576_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.20705e-06
NZ_CP013220.1\|WP_058084613.1\|624460_625387_+\|alpha/beta-hydrolase	gnl\|CDD\|223999	COG1073, COG1073, Hydrolases of the alpha/beta superfamily [General function prediction only].	1.0729e-23
NZ_CP013220.1\|WP_058084625.1\|646841_647603_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	8.38387e-12
NZ_CP013220.1\|WP_058085378.1\|629593_630919_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	1.16385e-119
NZ_CP013220.1\|WP_058084619.1\|633916_636739_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	4.51156e-12

>NZ_CP013220.1|WP_058084619.1|633916_636739_+|helix-turn-helix-domain-containing-protein
MNAQTRLSPLTAVEEAQPALSLVAPRRGALPDDPGLVGRDRELRALEEFLREARAHGAARVLCGHPGAGKSALLEAAVQAAAATGMRVLRCTGIRGGYPPDLSGLLQIVWPVLTGPHRPDAAGPLDALERVLVDGAPAPGGPSWLPFAVLRVLESVSRAGQPLLVAVDDWDALDPPSRDVLAFVARRAEGHPLALLMTCRPHRTRPASLAGLPGLPLGPLDPAASARLLAARRPGLEAQAVRELLATAAGNPLALLELPAGSEDSPPCMPASSDRLASALAPGAAHLPPRTRDLLLVAALHPAGDLPLLLSAASRIGGAELDFTALDPAERAGLVAFDGMRLRFGHPATAGAVVHGTDPRRCRAAHAALAAVLAPGSVQMLWHRSQAVQECDPELAGRLEAVHAQALEQCEPLMAVRLLRRASDLHPLPADRGRCALRAAQLAHVLGLERMTRTMAHRALRQPLGPLGRLCAEALTGTGNGGQPPADPAAWPAPAGAAEQENALELARITAPAVAGDDARAEALLAFLDAMPDLSDEPRVLHAMATAGPVRRAATVLAGVSAVRHLADVPVRDLERLGAAALLAGDPLRALDLYRQAERRHRFHDRSDQLPRVLLRQGLAHLAMGDRGQSGHAFRRCAERAEAYGQDHHAAAARLLEDLVRGLRTGGTVRPGSAADLEAARRSVRSIDAVLAVGTACALVEAGEYGAAWPALSSLLADPRSHAAALFALIPFAEAAEAENASEEALATLDRIEADLGAECPPVVAVRFAVARAVLADDRDDQGDRGDQDAQTLSERAFAEDLSRWPSLEAPLRLAQGRRLRRRRQFADSRTALRQAAAGYTMLGAEARLARIAGELRAAGERADGGAPGVSRPAAARDLLTPQELRIAELAGRGLSNREVGEQLGLAPRTIGAYLYRIFPRLGVTARAQLTEALRDPQAA
>NZ_CP013220.1|WP_058084618.1|632871_633222_+|MerR-family-transcriptional-regulator
MTSDNPLNDRLDDDDYPAYTMGRAAEMLGTTPAFLRAIGEARLITPLRSEGGHRRYSRYQLRIAARARELVDKGTPIEAACRIVILEDQLEEAQRINAEYRRAASQSASGSGSGSA
>NZ_CP013220.1|WP_014669103.1|631865_632240_-|hypothetical-protein
MSNPDELLVAISAAVESERSNQMSLTVIVGGAVITGRLAPEAVWRERVAEVLKDSDRLGPFSDLFARAPRGNRPGRGEAPTHLHFHLARIVQGSLGIPETGGMYRVAIKDVSAWTVGDLIHFDR
>NZ_CP013220.1|WP_058084617.1|631416_631737_+|hypothetical-protein
MRCVIARYPFDLTRTGVLASMKGVRPELVTGASVTIGRRRYPVKQVGQVVTRQDPRDFTAGEVVRAMTRLGFTCHDRPEDAPVGAGGPTVLRTASAPLGGTGPVAV
>NZ_CP013220.1|WP_058084616.1|631048_631354_+|hypothetical-protein
MPDPAPVTAVEDTEGHGPRVSDDMTVEVALAVMAGARVEYLTVCDGDDESTGLVTRVRLAVVRNSSAYTDRIRLRDVRDGPLPTPGVGGHGRVPGVPAHSR
>NZ_CP013220.1|WP_058085378.1|629593_630919_+|DEAD/DEAH-box-helicase
MPAVESFADLAMPAPLLATLGHEGVTVPFPIQAATLPNALAGRDVLGRGRTGSGKTLAFGLAVLARTTGRRAEPRRPLALILVPTRELAQQVTEALAPYARSVSLRLATVVGGMSLGRQAQALRAGAEVVVATPGRLKDLIDRGDCRLDDVGTTVLDEADQMTDMGFMPQVTALLDQVRPEGQRLLFSATLDRNVDLLVRRYLTDPVVHSVDPSAGAVSTMEHHVLHVHDADKHRTTTEIAARDGRVIMFLDTKHAVDRLTEHLLNSGVRAAALHGGRSQPQRTRTLAQFKDGHVTVLVATNVAARGIHVDSLDLVVNVDPPSDHKDYLHRGGRTARAGESGSVVTLVTPGQRRGMTRLMASAGITPHITSVRSGEAELSRITGAQAPSGVPVVISAPVAERPRRGSSPSRSRRRRTGQGRPVGEGARRRAQRLPGKDSAA
>NZ_CP013220.1|WP_028799214.1|629063_629267_+|cold-shock-protein
MATGTVKWFNAEKGFGFIEQDGGGADVFAHYSNIATQGFRELLEGQKVSFDIAQGQKGPTAENIVPA
>NZ_CP013220.1|WP_058084615.1|625981_628237_+|helix-turn-helix-domain-containing-protein
MDKAEFGRLLRAARQRALLTLESLAEASGVSVRAISDMERGQSLPRQATLSELMDALELDEDERRRFVEAAMRRTEQVPRQLPPDLATFRGRTEALTAVHRLTSHVAGRGAHVVISAIGGMAGVGKTALAVHWAHQVADRFPDGQLYVNLRGFEDSGRPLDPGAALAGFLDALGVPRSSIPPGTEERAALFRERAASRRLIVVLDNARDEEQVRPLLPASAGCLTIVTSRSQLSGLAVAEGAALVGLDVWSREEALAALAARIGEERCRAEPRAAAELVELCGFLPLAVAIVGAQVSASPQVPLGPVVRELRDSRTRLDALASGDRRVDVRAVFSWSYRALTPGTARFFRHLALHPGPSVSAEAAASLADVGTAAARRHLRELISANLVSRDAEGLYVLHDLVRAYGAELVERERDDRLGAESRLLDYLRYNAHWANRLLGRSVSDSVGPPADGVVRVPLDTREEALVWFRQEESAVAAALRSLEDPRLLRFRMNLTQDWVTYYSVTGRWTEEIETKRIGLDAALRLDEPAAIARNAADLARALAETGRLDEADRQVELLLGLLDRLDPVDRAATERSIGWVRGRQQRHAEALHHARRALEIYRAQGDEGTTAREMNAVGWYLALLGRYEETIALCEEAVPLLRRHGNLRIEAAARDTMGYARQRLGDLDAAVADYQESLRLYGEAFDGYNQAEVLDHLATAQKERGDRAGARESWLRAADLLNAIHSPRAERMRANAHALDTATTPTEQT
>NZ_CP013220.1|WP_058084614.1|625413_625701_-|hypothetical-protein
MVTRTVWLVGFAFRSERGRLVQHFYVVPEAADAEAAREAALRRAGTPRERALRGGLDIEEATAETRLLVRDGLGVWRLGGRGPSSGQPSVFPAAV
>NZ_CP013220.1|WP_058084613.1|624460_625387_+|alpha/beta-hydrolase
MARTSVTFDSAGIEIAAHLYTPDTPAPGPRPALVVGHPGTAVKEQTSGTYAQRMAERGFLALAFDAAYQGASGGLPRGLEDPAQRVEDFKAAVSYLTTREDVDAGRIGLLGICASGGYSLTATGADHRVRAVATVSGVDVARQFRYGADGTQDPAVFQALLDAAAHARTAAARGEDPGVMPVFPPTAEQAGALGGEHGVEGFDYYCTSRGEHERSAKYFVWQSVDKLASFDAFLAVPLIGPRPILQIIGERAVTAWMAVQAHQRATGPKELHRIEGASHVDLYDKKQYIDPAIDKLTDFFTTHLGTTS
>NZ_CP013220.1|WP_058084620.1|637128_640188_-|AAA-family-ATPase
MSAHIGSYDVGSDGTGLLGRERERNMVAALLTALPRGEGRVLHLSGAPGTGKSAVVRFAAAAAGRQGIRVLTTAWAPGERGLRHAALHRLLRPALPGSTGLPARERALLDAAFGGGDAAPGTGEPAVADTCEPAAPGMCEPVVPGTSAVAGPVSARLVPSAPAEPAAPAPARLAATVMRLLTGAAEPVLLCVDDLDRLDGASRDTLRALARLCGATRVGLIVAERAAAGVRPLPDALAMTPDALTVTLGSLPAPQARALVTRAGRATGYAEEQLVLAVARGNPLALTELSLDGGHLGDAAGFGMLPATSRLAEAYAEDVEGLSAPARTVLLTAALSASPVTRDILRACTSLLGSGRAARAGLAETIARGLVAESAGDVGPAGVVGTGGAGAGAAELDEEGGEEGGGEGGEENRRLYFPEPLVRPAVLHLESAARRLAAHHALGRCLTSRPHAAWHTAQCVAGPDEELARRLEALAAGPRPGTAVLVALAALDRAARLSPDPERRAARLLRAAELACDHGLTDQALGHARRIDPSELGTFGRALLLWVHDLLPGNSAVGRERIAELCEAARAVAPQDPALTQKLLHAAARRCWWQQAGPGERHMVLRAFEDLRSGPRDARDTAVMALTAALPLPQAEPPHSAPGPAGGDGDGGGDGGGDGDGDEQHLAGQVAVLVSDLDRAAPLLEEAEAAVRAGGRYGRLPQLLVPRAMGQIWLGTQWHTAQALAEEGRMIAGRTGQPDWVARATGTLAIIAALRGQHDKALEYAAEVEEASLRLGQNRQLNLAALARALTASGTGRYVEAYARLRFLFADPAAPYAFEQMWGLAFLAEAALPAGEQADARTVVEHVTALTEAGRAPLPQRILEYADAVLAPDDEAEVRYRRALRPGAGAWPLLHGMTQFGYGAWLRRRRRVTDSRTPLATAESVLRSLGAQSRAEQAASELRATGQATDGQSGADDIARVLSPQQLTIARLAARGLTNRAIGEQLRLSPRTVASHLYQIFPKLGVSSRAQLAARIGPD
>NZ_CP013220.1|WP_014669098.1|640349_640784_-|hypothetical-protein
MQLHLNPPLEPANAPRHAAAIVAAAADISGAELDYSPESIDLVEDIVDGFRAEGVTGEDMAESLVAFGCYVGEILTRHIGGAWRHAPAARPVGVPIVVELPDARECHPIDWVFGRLEFGADVSIRDLYAAAGADSAFPDEPTCE
>NZ_CP013220.1|WP_015493116.1|641000_641576_+|TetR/AcrR-family-transcriptional-regulator
MARSRGFDTDAAVEQAMGLFWKQGYRATPMPRLTELLGIGSGSLYAAFGSKDGLYAQALRRYCEGLVAALDRDVRAGDDIRTALRRLLLAMVTADAADPERGCLLVNAIVERAAHDGTVRQVRTAMAAIEAVLAEALERARVRGELSGERSPVEVARFLTTFIQGLHVMSQARTDRAFLEPAVAVALRVLD
>NZ_CP013220.1|WP_107113041.1|641727_641937_+|hypothetical-protein
MVARQAHWNLYGPRIRSIRLQLDEVVTTAREYADVVAERAAALGVSPDGRAATSGVPASAPGWTNENRG
>NZ_CP013220.1|WP_079088355.1|642024_642564_-|hypothetical-protein
MRHVFPCGTPALDFVGTLQERRAPVPIERIGSPGLLDSWFVESGLLDERPASDRADLCAALELREAIYLLVRARLVGTPLPAGALTAVNRRAAGVPVALCLGPGGTSRSGTAAQALADLAREAVEIVAGPDSALLRECGHPDCTHVYLDRSRGRRREWCAMRTCGNRVKAAALRARRRQ
>NZ_CP013220.1|WP_058084621.1|642682_643111_+|hypothetical-protein
MAVVRFHLVSTLSPKDVLGVLTDFRPSRATAWPTIDAGHFEVHGLGDTWAEVTEGTAAAWERARYDWEPDGDTVTVTTLDSKLFGAGGGWVFRMTPEGDGTRVDVELTRQPSTFKGKMLASLLPLAAPSSLRKSFAGPLQAK
>NZ_CP013220.1|WP_058084622.1|643215_644142_-|alpha/beta-hydrolase
MARTSVTFDSAGIEIAAHLYTPDTPAPGPRAALVVGHPGTAVKEQTSGTYAQRMAERGFLALAFDAAYQGASGGLPRGLEDPAQRVEDFKAAVSYLTTREDVDAGRIGLLGICASGGYSLTATGADHRVRAVATVSGVDVARQFRYGADGAQDPAVFQALLDAAAAARTAAARGEDPGVMPVFPPTAEQAGALGGEHGVEGFDYYCTSRGEHERSAKYFVWQSVDKLASFDAFLAVPLIGPRPILQIIGERAVTAWMAVQAHQRATGPKELHRIEGASHVDLYDKKQYIDPAIDKLTDFFTTHLGTTS
>NZ_CP013220.1|WP_058084623.1|644399_645248_-|SAM-dependent-methyltransferase
MGMTAFLVAAARAIETSRPDAPARDEYAEHLVRAAPGCADWPRRFDEVPDGDADPLWGRLARFFGLRTRVFDGFLLSAAAGGCRQVVVLGAGLDTRAHRLPWPDGSTVFEIDLEEVLAFKQSVLDTLGAVPRATRVALAADLRRDWTHALIAAGFDPTRPTAWVAEGLVPYLPPAAEQELIATVNAHSAPGSAFGYEVKRGVDPAGQRDYPVYAAVRERLGIDLLALFGTAPRPCSVADLDARGWDTAVHTPFDFADRHGVGLRPTPDDALAANRWILAVRP
>NZ_CP013220.1|WP_014669115.1|646226_646688_-|acyl-CoA-thioesterase
MPPTPTVDTPGTDVGVLMPVVVHFDDLDPMGLLHNGHYQVLVERAWGWFWRDKGIGGKSGLEGDGFNVAKHFDITYDQPVAGIGEYAVHLWMTRLGTTSATAGYRVCSADGKTTYAHGSRTVVRLDSTTFTPTPWSERVWEIARTIGLPQERA
>NZ_CP013220.1|WP_058084625.1|646841_647603_+|TetR/AcrR-family-transcriptional-regulator
MTTETETEQAGTTLRQKIVLAAARLLEEGGLDAVSTRAVAARAGVPTPSIFRIFGDKEGLLEEVAEHGFRRYLDVKAELLTGDDPVQALRDAWDLHIRFGLEHPAYYSLVYGQVRPGHIPQAGRRAAAGLRHMITRVAAAGRLRMSVERATEVMHSAGVGTILTLMSRPEGVCDLRTADTAREMVIDTLTLPPAESGDGDDAAPRAAVVSSAMALLAALGQEGSVALSPAELSLLREWLNRLADAGDVGDADG

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

12792 : 70473

Tupanvirus(16.67%)

transposase,integrase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_058083625.1\|12792_14280_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_159103876.1\|14674_15151_-	hypothetical protein	NA	NA	NA	NA
WP_159103875.1\|15254_15926_-	hypothetical protein	NA	NA	NA	NA
WP_058083617.1\|17258_18059_+	rubrerythrin family protein	NA	NA	NA	NA
WP_058083616.1\|19030_19537_-	transglycosylase SLT domain-containing protein	A0A0M5M3L4	Enterococcus_phage	1.4e-16	46.1
WP_058083615.1\|20111_20585_-	hypothetical protein	NA	NA	NA	NA
WP_058083614.1\|20808_21123_-	plastocyanin	M4SLM5	Cyanophage	2.4e-06	35.7
WP_058084242.1\|21294_21585_+	helicase	NA	NA	NA	NA
WP_058083613.1\|22646_22901_-	hypothetical protein	NA	NA	NA	NA
WP_058083612.1\|23264_24320_-	hypothetical protein	NA	NA	NA	NA
WP_162493806.1\|24457_25262_-\|transposase	IS5 family transposase	A0A0M5M147	Mycobacterium_phage	4.9e-24	32.7
WP_058084247.1\|26006_26426_-	hypothetical protein	NA	NA	NA	NA
WP_058084248.1\|26719_27328_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_058084249.1\|28643_28850_-	hypothetical protein	NA	NA	NA	NA
WP_058084250.1\|29750_31124_+	deoxyribodipyrimidine photo-lyase	A0A1V0S949	Catovirus	1.7e-40	28.9
WP_058084251.1\|32839_34981_-	MMPL family transporter	NA	NA	NA	NA
WP_079088430.1\|35150_35558_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_058084253.1\|35698_35884_+	hypothetical protein	NA	NA	NA	NA
WP_058084254.1\|36020_36605_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_058084255.1\|36601_37357_+	anti-sigma factor	NA	NA	NA	NA
WP_058084256.1\|37376_37685_-	hypothetical protein	NA	NA	NA	NA
WP_058084257.1\|37771_38434_-	fasciclin domain-containing protein	NA	NA	NA	NA
WP_107113025.1\|38538_40284_-	sulfite oxidase	NA	NA	NA	NA
WP_058084259.1\|40901_41108_+	DUF397 domain-containing protein	NA	NA	NA	NA
WP_058085327.1\|41268_41982_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_058084261.1\|42779_43190_-	ATP-binding protein	A0A1V0E640	Streptomyces_phage	1.1e-06	38.0
WP_058084262.1\|43401_44208_-	DUF1295 domain-containing protein	NA	NA	NA	NA
WP_058084263.1\|44204_45512_-	class I SAM-dependent methyltransferase	A0A2K9L4K8	Tupanvirus	2.3e-23	27.0
WP_058084264.1\|45508_46807_-	methyltransferase domain-containing protein	A0A2K9L0U7	Tupanvirus	2.4e-28	29.0
WP_107113055.1\|46803_47568_-	DUF1365 domain-containing protein	NA	NA	NA	NA
WP_058084265.1\|47561_48857_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_058084266.1\|49276_49876_-	DNA starvation/stationary phase protection protein	NA	NA	NA	NA
WP_159103883.1\|49960_51340_+\|transposase	IS3 family transposase	A0A0N7C1X7	Escherichia_phage	4.9e-64	40.7
WP_058085329.1\|52049_52277_+	hypothetical protein	NA	NA	NA	NA
WP_058084268.1\|52444_53356_-	transcriptional regulator CynR	Q6JIH3	Burkholderia_virus	2.5e-08	27.6
WP_058084269.1\|53480_54089_+	carbonate dehydratase	NA	NA	NA	NA
WP_058084270.1\|54200_54671_+	cyanase	NA	NA	NA	NA
WP_058084271.1\|55416_55890_+	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_058085330.1\|56481_56610_+	hypothetical protein	NA	NA	NA	NA
WP_058084272.1\|57371_58637_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_058079300.1\|58772_59276_+	hypothetical protein	NA	NA	NA	NA
WP_079088222.1\|59418_60498_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_063823321.1\|60642_61251_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_058084274.1\|61175_61715_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_107113056.1\|62805_63990_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_079088306.1\|64584_68766_-	hypothetical protein	A0A1V0SLL0	Klosneuvirus	2.8e-22	31.2
WP_058084278.1\|69291_69591_+\|transposase	transposase	Q9ETV7	Enterobacteria_phage	4.5e-07	39.0
WP_079088307.1\|69587_69908_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_159103884.1\|70224_70473_+\|transposase	transposase	Q6J1X2	Lactobacillus_phage	7.8e-05	42.6

DBSCAN-SWA_2

81165 : 138206

Trichoplusia_ni_ascovirus(28.57%)

transposase,integrase

attL 84021:84038|attR 99324:99341

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_079087880.1\|81165_81957_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_063823322.1\|82289_82697_-	hypothetical protein	NA	NA	NA	NA
WP_058084285.1\|83018_83327_+	hypothetical protein	NA	NA	NA	NA
WP_159103889.1\|83323_83470_+	hypothetical protein	NA	NA	NA	NA
84021:84038	attL	NA	NA	NA	NA
WP_058084286.1\|84165_84645_+	hypothetical protein	NA	NA	NA	NA
WP_058084287.1\|84769_84958_+	hypothetical protein	NA	NA	NA	NA
WP_058084288.1\|85223_86081_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_058084289.1\|87186_87426_+	hypothetical protein	A0A1B3AYL7	Gordonia_phage	2.6e-05	46.7
WP_058084290.1\|87425_87803_+	hypothetical protein	NA	NA	NA	NA
WP_058084291.1\|89060_90464_+\|transposase	IS1380 family transposase	A0A222ZN33	Mycobacterium_phage	4.6e-86	43.8
WP_079088312.1\|90627_91152_+	hypothetical protein	NA	NA	NA	NA
WP_058084292.1\|91162_92263_-	hypothetical protein	NA	NA	NA	NA
WP_063823321.1\|93069_93678_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_058084274.1\|93602_94142_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_079088433.1\|95127_96186_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_159103892.1\|100659_101268_+	hypothetical protein	NA	NA	NA	NA
99324:99341	attR	NA	NA	NA	NA
WP_058084295.1\|101264_101603_+	hypothetical protein	NA	NA	NA	NA
WP_079088222.1\|102316_103396_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_058079300.1\|103538_104042_-	hypothetical protein	NA	NA	NA	NA
WP_030655824.1\|104804_105494_-	nickel pincer cofactor biosynthesis protein LarB	A0A096XTB6	Enterococcus_phage	4.7e-15	32.1
WP_058084297.1\|105490_106771_-	nickel-dependent lactate racemase	NA	NA	NA	NA
WP_058084298.1\|106767_107703_-	amidohydrolase family protein	NA	NA	NA	NA
WP_058084299.1\|107699_108695_-	aldo/keto reductase	NA	NA	NA	NA
WP_058084300.1\|108694_109546_-	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_058084301.1\|109658_110363_-	FadR family transcriptional regulator	NA	NA	NA	NA
WP_058084302.1\|110666_111974_+	fuconate dehydratase	NA	NA	NA	NA
WP_058084303.1\|111970_112729_+	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	1.9e-09	30.3
WP_058084304.1\|112829_113906_+	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_058084305.1\|113926_115435_+	sugar ABC transporter ATP-binding protein	A0A2R8FG22	Brazilian_cedratvirus	1.8e-11	32.3
WP_058084306.1\|116569_118987_+	glycoside hydrolase family 95 protein	NA	NA	NA	NA
WP_058084307.1\|119457_119775_-	hypothetical protein	NA	NA	NA	NA
WP_058084308.1\|120083_120866_+	FadR family transcriptional regulator	NA	NA	NA	NA
WP_058085335.1\|120850_121699_-	amidohydrolase family protein	NA	NA	NA	NA
WP_058084309.1\|121683_122022_-	L-rhamnose mutarotase	NA	NA	NA	NA
WP_058084310.1\|122018_123200_-	mandelate racemase/muconate lactonizing enzyme family protein	Q6A202	Oenococcus_phage	3.5e-10	23.9
WP_058084311.1\|123231_124140_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_058084312.1\|124136_125090_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_058084313.1\|125091_126462_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_058084314.1\|127383_128145_-	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	5.4e-12	31.6
WP_058084315.1\|128141_129161_-	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_079088313.1\|129249_130299_+	aldo/keto reductase	NA	NA	NA	NA
WP_058084316.1\|131458_134107_+	right-handed parallel beta-helix repeat-containing protein	NA	NA	NA	NA
WP_058084317.1\|135154_135478_+	hypothetical protein	NA	NA	NA	NA
WP_058084318.1\|135598_136417_-	endonuclease/exonuclease/phosphatase family protein	NA	NA	NA	NA
WP_058084320.1\|136928_138206_+\|transposase	IS701 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

174387 : 246658

Bacillus_phage(25.0%)

transposase,integrase

attL 166539:166559|attR 216315:216335

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
166539:166559	attL	NA	NA	NA	NA
WP_058084347.1\|174387_175374_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_058084348.1\|175846_176728_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_058084349.1\|176797_177721_+	EamA family transporter	NA	NA	NA	NA
WP_159103897.1\|177717_178227_+	ATP-binding protein	NA	NA	NA	NA
WP_159103898.1\|178603_178903_-	hypothetical protein	NA	NA	NA	NA
WP_058084351.1\|180986_181235_+	hypothetical protein	NA	NA	NA	NA
WP_058085341.1\|181203_181719_-	N-acetyltransferase	A0A1P8CWJ6	Bacillus_phage	3.4e-18	33.3
WP_058084352.1\|182092_182659_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_058084354.1\|184096_184549_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_058084355.1\|184562_185630_+	NAD-dependent epimerase/dehydratase family protein	L7RCI0	Acanthamoeba_polyphaga_moumouvirus	2.1e-06	22.4
WP_159103899.1\|186109_186340_+	LysE family transporter	NA	NA	NA	NA
WP_058084274.1\|186371_186911_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_063823321.1\|186835_187444_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_159103900.1\|187701_188607_-	hypothetical protein	NA	NA	NA	NA
WP_159103901.1\|189150_189879_+	hypothetical protein	NA	NA	NA	NA
WP_159103902.1\|190347_192552_-	CHAT domain-containing protein	NA	NA	NA	NA
WP_159103903.1\|192728_193295_-\|transposase	IS3 family transposase	A0A0N7C1X7	Escherichia_phage	8.5e-23	37.9
WP_058084359.1\|193532_193967_+	amidohydrolase family protein	NA	NA	NA	NA
WP_159103904.1\|194462_194666_+	hypothetical protein	NA	NA	NA	NA
WP_058084362.1\|195072_196533_-	DUF642 domain-containing protein	NA	NA	NA	NA
WP_058084363.1\|196661_197225_-	DUF642 domain-containing protein	NA	NA	NA	NA
WP_058084364.1\|198824_199049_-	hypothetical protein	NA	NA	NA	NA
WP_159103905.1\|200352_200502_-	hypothetical protein	NA	NA	NA	NA
WP_058084366.1\|202504_202846_-	hypothetical protein	A0A142K9D3	Gordonia_phage	4.4e-06	40.7
WP_107113029.1\|203073_204054_+\|transposase	IS481 family transposase	NA	NA	NA	NA
WP_058084368.1\|205253_206126_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_041664925.1\|206271_206676_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_063823301.1\|207162_209118_+	hypothetical protein	NA	NA	NA	NA
WP_159103906.1\|209102_209288_-	hypothetical protein	NA	NA	NA	NA
WP_058084370.1\|209353_209935_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_058084371.1\|209970_211233_+	alpha/beta hydrolase fold domain-containing protein	NA	NA	NA	NA
WP_058084372.1\|211290_211701_-	VOC family protein	NA	NA	NA	NA
WP_058084373.1\|212701_212905_-	hypothetical protein	NA	NA	NA	NA
WP_107113030.1\|212924_215741_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_058084374.1\|215961_216321_+	hypothetical protein	NA	NA	NA	NA
WP_058085343.1\|217950_220140_-	MMPL family transporter	NA	NA	NA	NA
216315:216335	attR	NA	NA	NA	NA
WP_079082465.1\|221664_222363_+	response regulator transcription factor	NA	NA	NA	NA
WP_159103907.1\|222907_223093_-	hypothetical protein	NA	NA	NA	NA
WP_058084377.1\|223233_224508_-	metallophosphoesterase	NA	NA	NA	NA
WP_058085344.1\|224766_225993_-	cytochrome P450	NA	NA	NA	NA
WP_058085345.1\|226004_227195_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_058084378.1\|227206_227404_-	ferredoxin	NA	NA	NA	NA
WP_058084379.1\|227642_228320_-	response regulator transcription factor	NA	NA	NA	NA
WP_058084380.1\|228316_229615_-	sensor histidine kinase	NA	NA	NA	NA
WP_058084381.1\|229966_232222_-	MMPL family transporter	NA	NA	NA	NA
WP_058085346.1\|232394_233246_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_107113060.1\|233664_234210_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_058085347.1\|234316_234721_+	winged helix DNA-binding protein	NA	NA	NA	NA
WP_041666057.1\|235672_235900_+	ferredoxin	NA	NA	NA	NA
WP_058084383.1\|235896_237264_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_058084384.1\|237299_238520_+	cytochrome P450	NA	NA	NA	NA
WP_041665681.1\|239225_239699_-	hypothetical protein	NA	NA	NA	NA
WP_058084385.1\|239963_240515_-	hypothetical protein	NA	NA	NA	NA
WP_058079306.1\|242148_243414_+\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_058084386.1\|243596_243809_-	hypothetical protein	NA	NA	NA	NA
WP_058084387.1\|243876_244611_+	hypothetical protein	NA	NA	NA	NA
WP_058084388.1\|245337_245883_-	hypothetical protein	NA	NA	NA	NA
WP_148282127.1\|246403_246658_+\|transposase	transposase family protein	NA	NA	NA	NA

DBSCAN-SWA_4

1803785 : 1861621

Acanthocystis_turfacea_Chlorella_virus(40.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_058085485.1\|1803785_1804556_+\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_058085300.1\|1806526_1807297_-	hypothetical protein	NA	NA	NA	NA
WP_058085301.1\|1807557_1808067_+	SigE family RNA polymerase sigma factor	NA	NA	NA	NA
WP_058085302.1\|1808059_1808872_+	hypothetical protein	NA	NA	NA	NA
WP_079088423.1\|1809885_1810671_+	TIM barrel protein	NA	NA	NA	NA
WP_058085303.1\|1810684_1810918_-	hypothetical protein	NA	NA	NA	NA
WP_058085304.1\|1810965_1812396_-	UbiD family decarboxylase	NA	NA	NA	NA
WP_058085305.1\|1812471_1813062_-	UbiX family flavin prenyltransferase	NA	NA	NA	NA
WP_058085306.1\|1813230_1814094_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_058085307.1\|1814571_1814781_+	hypothetical protein	NA	NA	NA	NA
WP_058085308.1\|1815666_1816449_+	hypothetical protein	NA	NA	NA	NA
WP_079088476.1\|1816526_1818575_+	ABC transporter substrate-binding protein	M1HTZ5	Acanthocystis_turfacea_Chlorella_virus	5.1e-09	26.1
WP_058085309.1\|1818577_1820731_+	ABC transporter substrate-binding protein	M1I231	Acanthocystis_turfacea_Chlorella_virus	1.3e-10	27.4
WP_058085310.1\|1820839_1821418_-	AAA family ATPase	NA	NA	NA	NA
WP_058085312.1\|1824274_1824844_-	hypothetical protein	NA	NA	NA	NA
WP_159103955.1\|1825347_1826019_-	hypothetical protein	NA	NA	NA	NA
WP_079088477.1\|1826763_1827714_+	oxidoreductase	NA	NA	NA	NA
WP_014670151.1\|1828273_1829113_+	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_014670152.1\|1829269_1829476_+	cold-shock protein	A0A2H4N7Y6	Lake_Baikal_phage	6.7e-18	62.7
WP_058085315.1\|1831359_1832505_-	cell surface receptor IPT/TIG domain-containing protein	NA	NA	NA	NA
WP_058085316.1\|1833334_1834405_+	hypothetical protein	NA	NA	NA	NA
WP_079088478.1\|1835400_1835823_-	Ig-like domain repeat protein	NA	NA	NA	NA
WP_079088425.1\|1836033_1837053_-	cell shape-determining protein	A0A222ZEQ0	Arthrobacter_phage	6.5e-05	37.2
WP_014670158.1\|1838043_1838790_+	cell surface protein	NA	NA	NA	NA
WP_079088426.1\|1839341_1845668_-	type I polyketide synthase	D0R7J2	Paenibacillus_phage	1.5e-27	33.7
WP_079088479.1\|1845912_1847181_-	ketoacyl synthase	NA	NA	NA	NA
WP_014670161.1\|1847926_1848331_-	hypothetical protein	NA	NA	NA	NA
WP_058085318.1\|1849603_1850155_+	ATP-binding protein	NA	NA	NA	NA
WP_079088429.1\|1851280_1852366_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_058085490.1\|1852435_1853266_-\|transposase	transposase	NA	NA	NA	NA
WP_058085320.1\|1853562_1853997_+	hypothetical protein	NA	NA	NA	NA
WP_058085321.1\|1855903_1857181_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_058079300.1\|1857303_1857807_+	hypothetical protein	NA	NA	NA	NA
WP_079088222.1\|1857949_1859029_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_058084249.1\|1859271_1859478_+	hypothetical protein	NA	NA	NA	NA
WP_079088222.1\|1860541_1861621_-\|transposase	IS630 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP013219

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP013219_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013219_1

460799-460882

Orphan

Consensus_repeat	Method
GGCCACGCGCGTACGGGACGTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013219_1

>merge|NZ_CP013219|1|460799-460882|CRISPRCasFinder
GGCCACGCGCGTACGGGACGTCCGTCGGGTGCCAACCCGAGGAGTGACCCCGTGAGGGGGCGGCCACGCCCGTACGGGACGTCC

>NZ_CP013219|1|1|460799-460882|CRISPRCasFinder
GGCCACGCGCGTACGGGACGTCC	GTCGGGTGCCAACCCGAGGAGTGACCCCGTGAGGGGGC
GGCCACGCCCGTACGGGACGTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013219.1\|WP_014670503.1\|457662_458310_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058079122.1\|454148_457652_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP013219.1\|WP_058079120.1\|451455_452748_+\|1,4-beta-xylanase	unknown	unknown	gnl\|CDD\|377643
NZ_CP013219.1\|WP_058079123.1\|458501_459290_+\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|252734
NZ_CP013219.1\|WP_058079131.1\|472285_473197_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP013219.1\|WP_058079117.1\|446938_447817_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP013219.1\|WP_058079132.1\|473374_473713_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058079126.1\|465419_466442_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP013219.1\|WP_058079121.1\|452872_454147_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP013219.1\|WP_058079128.1\|467981_470168_+\|beta-glucosidase	unknown	unknown	gnl\|CDD\|185053
NZ_CP013219.1\|WP_014670498.1\|449699_449990_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_014670505.1\|459509_460610_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP013219.1\|WP_058079129.1\|470230_470488_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058079130.1\|470510_471599_+\|chitin-binding-protein	unknown	unknown	gnl\|CDD\|376983
NZ_CP013219.1\|WP_058079125.1\|464506_465235_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187578
NZ_CP013219.1\|WP_058079118.1\|448123_449377_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|379258
NZ_CP013219.1\|WP_014670517.1\|473743_474115_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058079119.1\|450413_451223_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP013219.1\|WP_058079124.1\|461842_464485_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP013219.1\|WP_058079127.1\|466697_467825_+\|glycosyl-hydrolase-family-5	unknown	unknown	gnl\|CDD\|366751

Protein	Function_ID	Function_description	E-value
NZ_CP013219.1\|WP_058079122.1\|454148_457652_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.05165e-55
NZ_CP013219.1\|WP_058079120.1\|451455_452748_+\|1,4-beta-xylanase	gnl\|CDD\|377643	pfam06283, ThuA, Trehalose utilisation. This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium.	7.17594e-37
NZ_CP013219.1\|WP_058079123.1\|458501_459290_+\|SAM-dependent-methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	4.44545e-127
NZ_CP013219.1\|WP_058079131.1\|472285_473197_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.64484e-34
NZ_CP013219.1\|WP_058079126.1\|465419_466442_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.24606e-116
NZ_CP013219.1\|WP_058079117.1\|446938_447817_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.00156e-28
NZ_CP013219.1\|WP_058079121.1\|452872_454147_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.73576e-63
NZ_CP013219.1\|WP_058079128.1\|467981_470168_+\|beta-glucosidase	gnl\|CDD\|185053	PRK15098, PRK15098, beta-glucosidase BglX.	3.74843e-101
NZ_CP013219.1\|WP_014670505.1\|459509_460610_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.14511e-41
NZ_CP013219.1\|WP_058079130.1\|470510_471599_+\|chitin-binding-protein	gnl\|CDD\|376983	pfam03067, LPMO_10, Lytic polysaccharide mono-oxygenase, cellulose-degrading. This domain is found associated with a wide variety of cellulose binding domains. This is a family of two very closely related proteins that together act as both a C1- and a C4-oxidising lytic polysaccharide mono-oxygenase, degrading cellulose. This domain is also found in baculoviral spheroidins and spindolins, protein of unknown function.	1.01186e-49
NZ_CP013219.1\|WP_058079125.1\|464506_465235_-\|NAD(P)H-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	7.44164e-21
NZ_CP013219.1\|WP_058079118.1\|448123_449377_-\|transcriptional-regulator	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	5.54338e-19
NZ_CP013219.1\|WP_058079119.1\|450413_451223_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.81701e-06
NZ_CP013219.1\|WP_058079124.1\|461842_464485_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.6375e-45
NZ_CP013219.1\|WP_058079127.1\|466697_467825_+\|glycosyl-hydrolase-family-5	gnl\|CDD\|366751	pfam01670, Glyco_hydro_12, Glycosyl hydrolase family 12.	4.24548e-62

>NZ_CP013219.1|WP_014670505.1|459509_460610_-|serine/threonine-protein-phosphatase
MRWLPVLYVAALLLLEPVTPVEWPVSFVLIALPLVAAFAHGPAVVGGATVFAVVLEGVLAGTPCCAGREVGYLWDRHYVASYICTGLVGVLGMILAGHRIRRERTLADLRFVADIAQRVLLRPVPHQIGSLHLDSLYRSAAAEARIGGDLYEAVPTRYGVRLLIGDVRGKGLLAVETAAALLGAFREAAHDEPALPALADRVETSMNRRAVLLGGSEVGERFVTAVFAEIPFGEPLIRVVNCGHPPPVRIRSGEVCELDRGRSAPPLNLGVLLGEPYHVDAYSFRPGDQLLLYTDGITETRDAAGSFYPLLQRLRSWSALPPRELLERLHRDLLAYSGDRLQDDIAALAVRLPADEPAVPATPPPG
>NZ_CP013219.1|WP_058079123.1|458501_459290_+|SAM-dependent-methyltransferase
MTTDSLPPLEIDTSKAHPARVYDWLLGGKDNYPVDEAVGQRLPAEARDAARQNRQFMHRAAAWLAGQGIDQFLDIGTGIPTQPNLHQIVQEIVPTAKVVYTDNDPIVLRHAEALLISSDEGVTDYIQADVREPDAIVRHARRILDFDRPIALSLIALMHFVTDEQDAHGIVRNLIATLPTGSHLVLSHAASDLYPELAAQVTAEYAKGGIQLGFRTRPEVERFFDGLDLVPPGLVTATEWGVSGTDAVPEGSGIYAAVARVP
>NZ_CP013219.1|WP_014670503.1|457662_458310_-|hypothetical-protein
MTVRYYVYISDSKVDMLLSQIDPDFGRRSTTEAGVSVKLFSVRRSVEAPAPDRTAKLERVLRHLEETGQTGSVDDPGPYFRGSLPMQWGPLNGENGGSLVYFGGRTEQTVLGLGGASGHVLGASAPQAQEFAPSSVPTLLAGLASAFAADSAEMPAEESSLAWVHTAGRLLRGPRQQVEFVARRLLSGPSPYPELDARPGMRVLLGSPLYVALAD
>NZ_CP013219.1|WP_058079122.1|454148_457652_-|protein-kinase
MALGTWRPGEVVLDLYEVLDDVRSGGMGVVHRVRHRGWNVDLAVKTPRPELVASETGRRRFEAEAGTWVSLGLHPHTVNCAYVRTVDGLPRVFAEWVDGGSLAEAITGGSLYEGGPRAALARVLDVAVQTAWGLQHAHDTGLVHQDVKPANVMLEPDGTAKVTDFGLAGARPADTGGTGAAPSAVTFGGMTPAYCSPEQALAAAGRREIRLTPATDVWSWALTVLEMFTGRRPTRYGQAAAAVLEALLDAGPADPRVPPMPPAVVGLLRQCFRTEATARPARLDEVADVLRDAYGDLTGTPFPRRAPQAAALLADGLSNQALSLLDLGRTEEAEARWREAMTAEPHHLVATFNFGLHRWRTAQKTDLDLVAELESAREISGDDVLGARLIGLVHLERDDRERAAELLRPAAPGEPDPAETEAALAELTRHPGTRPVVLAGHEAGVSAVAVSADGGLVLSGDHRGGLRLWETAGGRCLRELTSEGPAVVVTALDAEGRIGLVGREQGPPEAWDLAHGERLPLPPGPVAAGVTAVALSADGSVGVTGHADGTLLFRHLRTGRVLGPVQSQVELMTVLELSDDGAVALTAGDLRDDKVRLWDVATGVCRAVLTEPRANPLHSAWGGFVRRAAAAPGARYAVQVWGGPMVLWDVRTGRIATQAPHHLTDVTALALTPDGSLAVVGSGNPLQVVQTATGRCLRTLDEGTARHVHHLAVSADGRYAVLRTTDGVRIRVQPLPVPGYRAPWAYARPRPAGELSDHAGRFRAAMREGERLLDEGRYARSAAWLRTARAVPGHARHPDLRHAWNALGRHGRRTGLLGAWQTFDFTGRVAHPSALAFVGDTSLFLAALHGDRFLLCDAANARQYRVIASTATADVALVVTGDGTRAVVHGMGEAALLDLRDDRTVMVPHDAVRAVAWADDSGWLLTGDDSGHLCRWDIEDVARRHDHAKPSLAFRAHQEQVESVAISPDGRYGASNAFAGAEEDRQRRHDQDELCGWDLASGQRLWRRTGRPGRAGLRFTPDGRTLLEYGLSSVHSYDAASGRRICAVDGPYSVRTLVTSADGRRAVIAGYGTLVVLDPATGRVLREIRDPGLINTLTLTSDGRFALAGLAHQEVHVWDLDQGRRLRVLSGHQGQVFGLALSADARHLLAAGVDSVRCWELDWDYDW
>NZ_CP013219.1|WP_058079121.1|452872_454147_-|protein-kinase
MPSVTLTPDGAPTAAAYVFSHRTTCLVGRASECGIRLARTETKVSRHHCLLDVNPPHLRVRDLDSRNGTYVNGERLAPGSAGRDLADGDEIRVGGAVLRVSVQAGEPSPAHADARDPVDALHTLLDAAEAGEPGLTGIRGYRLLQELGRGGQGVVHLVRNEETGELLALKTLPAHRAVDPAARDGFLREFACTRALRHPHVVAFHGGGVHDSTFYFTCEFCRLGSVADLVARAGGRLGVDQAVGVTLQALRGLHYAHGAEVPVRLADGTSATHRGLVHRDIKPQNLLLTGARDRATVKVADFGLSKAFDSAGLSGHTLTGAMGGSLAFMPRGQVIDFKYALPEVDLWAMTACLYWMLTGSPPRDFPSGADPVAVVLREPVVPVRDRLPTLPRRLAAVIDTALVDAPRVTLTSAADLARAIRQAL
>NZ_CP013219.1|WP_058079120.1|451455_452748_+|1,4-beta-xylanase
MQQVRSGAARIPMWLAFLLAALVSLTAQPPAQAAPAAEPFRVLALYNGTYDAAHISFVHEANQWFPQQAAANGFTYTASNNWDLLANGGVNNYQVVLFLDDLPQSAAQRAGFEQYMRNGGAWMGFHVSAFTTDAQSWPWYHNQFLGSGNFVSNTWGPTTAVLRVEDRTHPSTRNLPATFTSSVSEWYSWSNDLRKNPDIKILASVDPSSFPLGTDPNQTWYSGYYPILWTNTKYKMLYANFGHNAMNYDTNTALSSTFASATQNQFVLDGLKWLGGAASSQPPADGISETAWYTLGNTGNGTCVDARAAGTANGTVIQQYTCNSTTAQQFQFRSTDSGYTRIAARGNPQQVVDVVDRSTADNAPLQLWSYGGGTNQQWLPVKEATGRYHFTARHSGKCLTASGSAADSVQLTQRTCDGSAAQSFQLTAQP
>NZ_CP013219.1|WP_058079119.1|450413_451223_-|GNAT-family-N-acetyltransferase
MTDGEDRAESVESMEQLAVVWRAMVLDRDTDADVRDLPGIAVRWADCRFAFWNCVTLTDIDTDTALVRERLGQAADIMRAKRHPGFLWLFEDLLGDEARAGVRTAAEEAGLEYAFPGTGMAGDILPLPEPSHPDLTFVRVTTEEHVRAYADLNSRAYGFPLEDGRDGLLGSALWKHQVHAYLGLRDGVPVACAGTVEAEGRLFVVLVATSPDWQRRGYGEAVTRKALYEGSRATGLTRATLHATEAGAPVYPRIGFRPNSPIHFYALKQ
>NZ_CP013219.1|WP_014670498.1|449699_449990_-|hypothetical-protein
MRVRRQLTSTLGSFALAFAFLGAGTATATPAAADPCGFYETGSDAYYNHCTSDGSHVVIKVEVALAPDYERCVAPGRTWLGSATKIQGAYYVGRTC
>NZ_CP013219.1|WP_058079118.1|448123_449377_-|transcriptional-regulator
MAERRLRIRVGSDALQELIEELAERLERSVVVDDPLVRLICSSQHFGDEDPVRIRSLLRGRADDVAIRYVLDQGVARWTKPGFIPGRDDLGLLTRYCVPLRERGELLGLLMVVAPDGTLTREEADQVAQAVPAISAQLRADQLAASADEVDLHETLHSLFGTGEAARAAARRQILDGGVLPDAPHAVVSVVQVSRSVEPPGQVEIALRASLERFLRTRSADGAMAATPDGAVLLQVSSKPLAAQELADQATAVREALAAYLEASAAPVLGIGGTQDGLADAWTSHAQAMVAARAARRLPHLKGVGAWESLGELAVLLHVPDHALTRSLVPTPLHRLLDSPGGQRLVDTLRCFLEHAGSIPRTAEALQIHRTSLYYRLRQIQEITGLDLDSGGDRLVLHLGLRTLELLQAETDVQPAV
>NZ_CP013219.1|WP_058079117.1|446938_447817_-|alpha/beta-hydrolase
MGAVEQLTTGDGVRLVYRDSGGEGFPLVMLHGWGQTQEMFRHQVRGLSPAHRVITLDFRGHGVSDKPYHGYRIARFAADVLDLVDQLGLDRFDALGWSMGASVWWSFVDQYGTGRLRRFVAVDQPAAVAAVPWMSVEEQRQSGAIFDVAGLLALGAQLAGPDGEQARYEFVRGMFSGDPDPAILSFVAEQIKATPAHAGVPLLFDHCAQDWRDVLPRIDVPTLVVGCDGSHVHPRSQQFVAQRIPGARLHVFPATVANSHFPFLENPPAFNDVVGAFLSEQPDPVDHTDVNV
>NZ_CP013219.1|WP_058079124.1|461842_464485_+|SpoIIE-family-protein-phosphatase
MLQALIMLLLVAAGATALVVQGRYDARRTAEDRSLAVAEAFAHAPGTAVALRSAHPAAQLQPATEQVQKGSGVDFVSVLDRRGIRITDNDPTLIGTKAGGVGRAATGEMYTETFHGPPADAVRAVVPVTDPGRRVVGVVTAGIQYGNVGQVLDQQLPMLLGMAAGALLLATGGAALVSRRLLRQTHGLGPAEMTRMYEHHDAVLHAVREGVVIVGGDGCVVLANDEAHRLLGLPGDADRRHVRELGLGPVLTRLLLSGETASDQVVPAADRLLAVNTRPTAPYGGAQGLVATFRDTTELRALSGQAEVARSRLSFLYEAGVRIGTTLDVRRTAEELSEVAVPRVADFVTVELLDSVLRGQEPTSAVREMRRTALRASRGGHPLQPAGEVIRLLVADTPMAAALRRGKAVLVPDLHCAEDWRAQDPEGARRALDYGIHSLVTVPLRARGVVLGMVNFWRGAGFPRFEEEDVAVAEELVARAAVAIDNARRYSREHALAVTLQRNLLPLGLPDQDALEVASRYLPAESGVGGDWFDVIPLPGFRVALVVGDIVGHGLQAAVTMGRLRTAVLNFSSLDLAPDELLGHLDEMVTRLDTQLDGPSATADDDRVPLTGATCLYAVYDPVGGHCTLSRAGHLAPAVVDPRGRVSFPDLPLSPPLGVGGHPFEAGELELPEGSRLVLFTDGLIENRGRDVDEGLAMLSSAIADADRTPEETCRVLVERMLPGHPSDDVALLVARTRLLDPACVATWDVPFDVEAVSRVRGEASRRLADWGLEETAFGTELILSELLTNAIRYGAPPVRVRLLLGRTLVCEVADGSNTSPRLRRAASTDEGGRGLFLVSQFADMWGTRYAPRGKVIWAEQRLEGAPEPDPSALLEVLGN
>NZ_CP013219.1|WP_058079125.1|464506_465235_-|NAD(P)H-binding-protein
MKVAVIGGTGLIGSQVVRNLKAAGHEAVPHSHSTGVDVISGQGLDEAVAGADVVVNTTNSPTFDAASLTFFQTSMDNLLAAARKGGVGHIVILSIVGVDQVPELDYYRAKAFQENILAAGGVPYSIVRATQFMEFMDDVLSWTTEGDTVRLPATPIQPVAARDVADAVAEVAVGAPLNGIRNIAGPEVFTLDELGRTTLSRKGDDRDVVTDPTAGMFAVVRGDVLTDPHARLAPTRYEDWLS
>NZ_CP013219.1|WP_058079126.1|465419_466442_+|LacI-family-transcriptional-regulator
MGKRRPGSPTLEEVAAHAGVGRGTVSRVVNNAAGVKESTRRAVQQAIAELGYVPNLAARSLAGRRADAVALVMTEPDWRKFAEPFFSEIVRSLGDALSDTGMQLLLTLVRSDTDRERFLEYARGGRVDGVLVMSVHADDPLPDMLAEARLPTVLLGRRSADEHVSYVDADNVGGARSAVAHLLDKGRRTIATITGPLDMYVTRCRLRGYREALAHAGLDAPPSWVAEGDFSAESGRRAMTRLIERHPEIDGVLAASDTTAAGALEALRAAGRRVPEDVAVIGFDDFPLAERTEPRLTTVRQPLEEIGRAMVRLLLEEMEESSVAWRHVILRTELVVRESA
>NZ_CP013219.1|WP_058079127.1|466697_467825_+|glycosyl-hydrolase-family-5
MRPYKHPVRGARGLLGALLTALAALAALLTVAPAAQAGTAICEQYGSTTIQDRYVVQNNRWGTSETQCIDVTDSGFRVAQADGSVPTNGAPKSYPSVYNGCHYTNCSPGTKLPARLSSISRAPTSISYSYVSNAVYDAAYDIWLDPTPRTDGVNKTEIMVWFNKVGSIQPVGSQVGTATVAGRQWQVWSGNNGGNDVLSFVAPSAITSWSFDVMDFVRQAVSRGLAQDSWYLTSVQAGFEPWQNGAGLAVTSFSSTVDTGSGDPGGPGNPAACKVAYGTNVWQGGFTAEVTVTNTGSSPVSGWRLAFALPSGQRITSAWGAAVTPSSGAVTASDLTYNAQIAPGGQVTFGFQGSYGGTFAKPSGFTLNGAACTTA
>NZ_CP013219.1|WP_058079128.1|467981_470168_+|beta-glucosidase
MSLPLARRRPVTALAVCAATLALTASAVAAPEPVAASPAAVLPYQDPSAPVPDRVSDLLARMTLDDKLGQMTQVEKDALVPQSDLAAYRIGSVLSGGDSTVSPNNAQTWADTYDSLQRTALTTPLGIPVIYGIDAVHGHNAVRGATLFPHNIGLGATRDPALVQRIGRAVAEEVSGTGIDWDFAPCLCVARDDRWGRTYESYGETPELPSSLTTFITGLQGEPLGEGPAPVLATAKHYLGDGGTAGGVDQGDTRLSEAELRAVHLPPFKEAVRRGVGAVMLSYSSWNGVRSHANRYLVTDLLKGELGFGGFVVSDWAAVDQLDGQSGFTGAEITTAVNAGVDMVMVPHDYKKFLTLVRGEVAAGRIAQSRIDDANRRILTKKFQLGLFERPFTDRSYTPTVGSAAHRELARQAVRASQVLLKNEGGVLPLPKSAKLFVAGKSADDIGNQSGGWTVGWQGRSGPVTDGTTVLEGIRAAVTDPSRVTYDRYGNGIDSSYRAAVAVVGETPYAEGRGDRPGGLGLDQEDLQTLARLRASGVPVVVVLVSGRPLDVSGRLPDWTALLAAWLPGTEGAGVSDVLFGDYAPTGKLPVSWPRTSSQEPVNDGDGKDPLFPYGYGLTYSGAGPTPPPAPGACTARFRTASSWQGGYQAEVTVENTGSTALTGWSVDWDLGGSRVTSLWNGSLTTAGSRATVRDAAFNGSLRPGDTTTFGFTAEGTAGTPAPHCAGS
>NZ_CP013219.1|WP_058079129.1|470230_470488_+|hypothetical-protein
MTHPTRRTPAHRPRPGRGRHRAASLGALFATLALGLTGQLTAHPAVETSAGTPSARPLGAGVTYTDAPAVPPYSGTAPARGLPPV
>NZ_CP013219.1|WP_058079130.1|470510_471599_+|chitin-binding-protein
MARRNRLMSVAAALSTLLAALALTLLGQTSAQAHGVAMLPGSRTYLCYLDAHTTTGGLDPTNPACRDALAKSGASALYNWFAVLDSNAGGRGAGYVPDGTLCSAGDRSPYDFRAYNAARSDWPRTHLTSGATIQAQYSNWAAHPGDFRVYVTKQGWSPTSALRWADLDLVQTVTNPPQQGSPGTDGGHYYWDLKLPSGRSGDALLFIQWVRSDSQENFFSCSDIVFDGGHGEVTGIRTSGGTPTPTPTPTPTDPHTGSCMATYSVVNSWSGGFQASVEVMNHGTAPLDGWAVAWQPGAGTKISSVWNGTLSTGTDGTVTVRNVDHNRAVPADGSVTFGFTATSTGNNVPAGSIGCVTGQGTT
>NZ_CP013219.1|WP_058079131.1|472285_473197_-|LysR-family-transcriptional-regulator
MREPSVHQLRLLLAVAEELHFKRAAARMFISQPALSQQIRALEERLGIGLVERGSGGARLTTAGAAVVEEARAVVAAMERLLRVSDAQADAVRRELCVGSLGAEAAMPHARVVLAHLRDHHPHLQVEVRNLNFVEQFDALANGEVDAAFLRGPLPPGLQSVRLASEPRVVCLPADDPLAGETTLTLAQLADRTVVDMPRDVPRLWWDHLTVNPRPDGTPVRFGPVVRDTEAMVLAVLQARAITFLPAAARQLYPRPGLVYVDAPELGESESYLAWLPAHRDVLAVRALREAARATAQDREQPP
>NZ_CP013219.1|WP_058079132.1|473374_473713_+|hypothetical-protein
MRRTRVLAALGVLTAAVVVAPVGTAAAAADGTSYGVVPYENVNVRKLPTKDSAYLATLTAGQTYRAYCWTHGQTITDNGYTNDIWIGFADGYSSAVYFKGDAYANLPASAQC
>NZ_CP013219.1|WP_014670517.1|473743_474115_+|hypothetical-protein
MNKISRGLAVAVTAAASVVALSGAAQARPAAGDWNGCPYGAVCIWGQDRNPYLDPHPTNVYWSYGAHNLSNQYGDHYVFNNQYGGASMSLCTGYNGAGCHLALLEQEIGSFNLTPYNSVTLNR

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Crispr_ID: NZ_CP013219_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013219_2

873901-874023

Orphan

Consensus_repeat	Method
GGGGCGGGCCGAGGGTGATCGTCGGCCGGCGCCT	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP013219_2

>merge|NZ_CP013219|2|873901-874023|PILER-CR
GGGGCGGGCCGAGGGTGATCGTCGTCCGGCGCCTTCCCGTGGGCGAGCGGGGCGGACCGAGGGTGGCCACCGTCCGGTGTCTTGCCGTTGGGGCGGGCCGAGGGTGATCGTCGGCCGGCGCGT

>NZ_CP013219|2|1|873901-874023|PILER-CR
GGGGCGGGCCGAGGGTGATCGTCGTCCGGCGCCT	TCCCGTGGGCGAGC
GGGGCGGACCGAGGGTGGCCACCGTCCGGTGTCT	TGCCGTTGGGGCGGGCCGAGGGTG
ATCGTCGGCCGGCGCGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013219.1\|WP_058079357.1\|876378_877800_-\|bifunctional-heptose-7-phosphate-kinase/heptose-1-phosphate-adenyltransferase	unknown	unknown	gnl\|CDD\|225425
NZ_CP013219.1\|WP_058079351.1\|870477_870681_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058079363.1\|885554_886562_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187541
NZ_CP013219.1\|WP_058079352.1\|870781_871990_-\|ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|366782
NZ_CP013219.1\|WP_014670858.1\|869518_869869_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225177
NZ_CP013219.1\|WP_058083703.1\|868999_869371_-\|ferredoxin	unknown	unknown	unknown
NZ_CP013219.1\|WP_058079355.1\|874051_874993_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133029
NZ_CP013219.1\|WP_058079349.1\|867101_867962_-\|DUF2236-domain-containing-protein	unknown	unknown	gnl\|CDD\|378343
NZ_CP013219.1\|WP_058079353.1\|872169_872673_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP013219.1\|WP_058079347.1\|863681_865469_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|179620
NZ_CP013219.1\|WP_058079358.1\|877796_878774_-\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|240139
NZ_CP013219.1\|WP_014670871.1\|880958_881969_-\|glycosyltransferase-family-9-protein	unknown	unknown	gnl\|CDD\|340821
NZ_CP013219.1\|WP_058079348.1\|865484_867047_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NZ_CP013219.1\|WP_058079361.1\|882894_883890_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133029
NZ_CP013219.1\|WP_014670870.1\|879999_880962_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|223515
NZ_CP013219.1\|WP_058079350.1\|869927_870383_-\|RpiB/LacA/LacB-family-sugar-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223770
NZ_CP013219.1\|WP_058079360.1\|881965_882898_-\|HAD-IIIA-family-hydrolase	unknown	unknown	gnl\|CDD\|319806
NZ_CP013219.1\|WP_058079356.1\|874982_875987_-\|glycosyltransferase-family-9-protein	unknown	unknown	gnl\|CDD\|340821
NZ_CP013219.1\|WP_058079354.1\|872797_873730_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133029
NZ_CP013219.1\|WP_058079359.1\|878770_880003_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340830

Protein	Function_ID	Function_description	E-value
NZ_CP013219.1\|WP_058079357.1\|876378_877800_-\|bifunctional-heptose-7-phosphate-kinase/heptose-1-phosphate-adenyltransferase	gnl\|CDD\|225425	COG2870, RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane].	8.03902e-89
NZ_CP013219.1\|WP_058079358.1\|877796_878774_-\|SIS-domain-containing-protein	gnl\|CDD\|240139	cd05006, SIS_GmhA, Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).	2.76899e-66
NZ_CP013219.1\|WP_058079363.1\|885554_886562_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187541	cd05230, UGD_SDR_e, UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs. UGD catalyzes the formation of UDP-xylose from UDP-glucuronate; it is an extended-SDR, and has the characteristic glycine-rich NAD-binding pattern, TGXXGXXG, and active site tetrad. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.28703e-159
NZ_CP013219.1\|WP_058079352.1\|870781_871990_-\|ANTAR-domain-containing-protein	gnl\|CDD\|366782	pfam01740, STAS, STAS domain. The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.	2.81644e-07
NZ_CP013219.1\|WP_014670858.1\|869518_869869_+\|hypothetical-protein	gnl\|CDD\|225177	COG2268, COG2268, Uncharacterized protein conserved in bacteria [Function unknown].	0.00450808
NZ_CP013219.1\|WP_058079355.1\|874051_874993_-\|glycosyltransferase	gnl\|CDD\|133029	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	4.52168e-28
NZ_CP013219.1\|WP_058079349.1\|867101_867962_-\|DUF2236-domain-containing-protein	gnl\|CDD\|378343	pfam09995, DUF2236, Uncharacterized protein conserved in bacteria (DUF2236). This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	2.90078e-59
NZ_CP013219.1\|WP_058079353.1\|872169_872673_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	3.62939e-08
NZ_CP013219.1\|WP_058079347.1\|863681_865469_+\|serine-hydrolase	gnl\|CDD\|179620	PRK03642, PRK03642, putative periplasmic esterase; Provisional.	3.26683e-58
NZ_CP013219.1\|WP_014670871.1\|880958_881969_-\|glycosyltransferase-family-9-protein	gnl\|CDD\|340821	cd03789, GT9_LPS_heptosyltransferase, lipopolysaccharide heptosyltransferase and similar proteins. Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	3.98122e-57
NZ_CP013219.1\|WP_058079348.1\|865484_867047_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	2.3101e-63
NZ_CP013219.1\|WP_058079361.1\|882894_883890_-\|glycosyltransferase	gnl\|CDD\|133029	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	3.02166e-25
NZ_CP013219.1\|WP_014670870.1\|879999_880962_-\|glycosyltransferase	gnl\|CDD\|223515	COG0438, RfaG, Glycosyltransferase [Cell envelope biogenesis, outer membrane].	5.85654e-16
NZ_CP013219.1\|WP_058079350.1\|869927_870383_-\|RpiB/LacA/LacB-family-sugar-phosphate-isomerase	gnl\|CDD\|223770	COG0698, RpiB, Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism].	3.97352e-37
NZ_CP013219.1\|WP_058079360.1\|881965_882898_-\|HAD-IIIA-family-hydrolase	gnl\|CDD\|319806	cd07503, HAD_HisB-N, histidinol phosphate phosphatase and related phosphatases. This family includes the N-terminal domain of the Escherichia coli bifunctional enzyme histidinol-phosphate phosphatase/imidazole-glycerol-phosphate dehydratase, HisB. The N-terminal histidinol-phosphate phosphatase domain catalyzes the dephosphorylation of histidinol phosphate, the eight step of L-histidine biosynthesis. This family also includes Escherichia coli GmhB phosphatase which is highly specific for D-glycero-D-manno-heptose-1,7-bisphosphate, it removes the C(7)phosphate and not the C(1)phosphate, and this is the third essential step of lipopolysaccharide heptose biosynthesis. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	6.38966e-57
NZ_CP013219.1\|WP_058079356.1\|874982_875987_-\|glycosyltransferase-family-9-protein	gnl\|CDD\|340821	cd03789, GT9_LPS_heptosyltransferase, lipopolysaccharide heptosyltransferase and similar proteins. Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	2.72578e-46
NZ_CP013219.1\|WP_058079354.1\|872797_873730_-\|glycosyltransferase	gnl\|CDD\|133029	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	4.92031e-29
NZ_CP013219.1\|WP_058079359.1\|878770_880003_-\|glycosyltransferase	gnl\|CDD\|340830	cd03800, GT4_sucrose_synthase, sucrose-phosphate synthase and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.	4.15346e-141

>NZ_CP013219.1|WP_058079354.1|872797_873730_-|glycosyltransferase
MTSTAPEAPTRTAPDDRTTVVLITHNRRDELLRTLALLRRLPERPPVIVTDNASTDGTAEAVAREFPEMTLLRPGRNLGAIGRNLAVQRVRTPYVAFCDDDTWWAPGSLRRAADLLDAGPRLAGVTARILVEPGGTEDPVVRELRESPLSGPDWLPGPALGSFLAAATVLRAEAFRAGGGFHPGLWLGGEEELLACDLLRQGWWLAYAEELTVHHHASRLRDSTARRVLGLRNTLWFTWLRRPLLPALRRTGHLIRTVPRDAASARAFAHATAGLPWVLRQRDPVPPDLERRLAALERARRNSPARRYVG
>NZ_CP013219.1|WP_058079353.1|872169_872673_-|STAS-domain-containing-protein
METRSPREDGQPSPARVRPGGPAPLLLQTVHEHRPGLGGISVLKARGTVDASNARLFSEALAEHVAHAGQAGEHLLLDLSEAYLACADAVRSLDRATGALAHTGRALSVVQPRPHVREALTSAGLPGIRVHATLASALDALTSREPAGERAYQPAYEPARPDPGGLG
>NZ_CP013219.1|WP_058079352.1|870781_871990_-|ANTAR-domain-containing-protein
MIESSVVEGLPAEGALLLRMSGSLDADGAQAWSEELRGHLEQADRAGLRPVLDMAHVQLGGAAVLRTLSETTRARTGRPDLIIVRARPGVREAVHLARLEGVRLYATLDEALHELARVASRVEELPAWRSQMADPLRPSYEDLYKEVRALRARVRTAPVIGMAQGTLMVRYGLPDSGSAFRALREASQRFNVPLRVLVSAVVVARPPDGDVWFPGRRSLPVPQLRMLARGGRDPRYRRQMIDAVLREALAIGKAPAGYVQFVDPAVNVLMLETHYGCAETFLDQLVRGRGDGTADAAARVRGRQVSVPDVATDARLSDDCRRALLATGTQALHSVPVLSSAGSCTGVITLHWPDAGHRTTAGQAEAFTLLASDTSAWLSWYHRSVLLDALEHLHRALTRPTP
>NZ_CP013219.1|WP_058079351.1|870477_870681_-|hypothetical-protein
MSNPQQPEQRRSDKGGATPQDSGELKARVPAGRDAGGRPHGSDKAGKGGKGGGEGGGVPPAQQPDHP
>NZ_CP013219.1|WP_058079350.1|869927_870383_-|RpiB/LacA/LacB-family-sugar-phosphate-isomerase
MRISVSSDMDEPVARLLVAELRRRGHEVREHGALTPGADAQWAVCSEAAARDVAEGAADQAVVCCWTGTGASIAANKVPGVRAALCVDAGTADGARRWNDANVLALSLRLTSEPVLKEILDAWFAAEPSQDPEDRRNVARVDRLDAARDSC
>NZ_CP013219.1|WP_014670858.1|869518_869869_+|hypothetical-protein
MQLAAASGLMSLFLFIVAVAVLALLAGGFWMTSRVRYRESPRPRPEEQPKLPPEGPVHEVRENRESAEIPQIPKGDRPLTPYELTNMDTRTSASKERPRWSKGSSGSFGGGGLGAH
>NZ_CP013219.1|WP_058083703.1|868999_869371_-|ferredoxin
MTSPTSQQLYRFLEDRFTCAQACTECARACAVRASLVDPDGSEHQERARQLGIMCAEVCDATCRVLCEENRQDEESIRVRVDWCRSVCLDCARAFDEHPGAESAAAACRACADACADFLETLR
>NZ_CP013219.1|WP_058079349.1|867101_867962_-|DUF2236-domain-containing-protein
MGTHADPGDPGLFTPASVTWQMHGDPMMWVAGIRALYLQALHPRAVRGVMQNSDFRRDAWGRLMRTAHFVGTTTYGTSGAAERAGARVRKIHSMLTATDPDTGERYGVDEPELLLWVHCAEIDSYLHVLRRSGFPLTDAQADRYIAEHRVSARLVGLDPHTVPASRAELAAYFEAVRPELAAGPEAHDVDDFLLRPPAHPLLVPARALLWRRVALLAYAALPPYAHELYGRPAPAPAVVTRRLRVTAAVLRRIPARLRWQLPPKHILRAMARLGPQARPAPHKVRA
>NZ_CP013219.1|WP_058079348.1|865484_867047_-|NAD(P)/FAD-dependent-oxidoreductase
MSANEGSRAYDAVIVGAGHNGLVAAAYLARAGRSVLVLERLDHTGGAAVSTRPFAGVDARLSRYSYLVSLLPDKIVRDLGLDFRVRSRTISSYTPAERAGRPTGLLVGGGEQRTREAFARLTGGDREYEAWRRFYGMTGHVAQRVFPTLTEPLPTRDELRRRIDDETAWRALFEEPVGAAIERTFTDDLVRGVVLTDALIGTFADAHDPTLVQNRCFLYHVIGGGTGAWDVPVGGMGALTDALAAAARAAGARIATGHEAIRIDTDGTTAEVVYRTAAGEGTAAARHVLVNASPHELAVLTGGPAPEPVEGAQLKVNMLLTRLPRLRDPEADPREAFAGTFHIAEGYRQLATAHAQAAAGELPAAPPSEIYCHSLTDPTILGADLAERGYQTLTLFGLHAPARLFDRDNDAVREELLKSTLAQLDAHLAEPLANCLATDADGRPCIEAKTPLDLERDLRLPGGNIFHRALSWPYAEEDSGRWGVETRHPNVLLCGAGAVRGGGVSGVPGHNAAMAVLERR
>NZ_CP013219.1|WP_058079347.1|863681_865469_+|serine-hydrolase
MTDHVAGGRASGPTRRRLVAGTLAAGGALALAALPAGPAAAAPASGRHPTLRHGSPERAGLLPAHLRQLVTDAEAFLAPSPRHPWYAGAVLLAGRGGTVALHEPIGMAVRYARYDEKTDTGVELPPEQQLPMTRDTVFDLASVSKLFTSLLAVQQIERGTLALEGTVASYLPEFGRAGKQSVTIRQLLTHTSGFRAWLPLYDAPTYEGKLQLIWDEAPLNPPGTAYLYSDLNLITLQLVLEKITGRTLDVLLRDEITGPLGLDSTRYNPPASWKPRIAATEDARRPWSGLDRGMVWGEVHDENAYSLGGVAGHAGVFASAWDLAVLGRTLLGGGSYGRTRILRPESVDLMFTDFNTAFPGDEHGLGFELYQHWYMGAMATPRTAGHTGFTGTSLVLDPTTDSFLVVLGNSVHPVRSWRSGSAPRVAAGNHLARAVPVRPASGRTAWFSGMANATAATLTLPALDTSSGAARLRCALWWDTEPRSDLVALESTTDGGTTWHPVPFTTARRGEDPEDHPAGTVTGWSGRVWHRLTAALPADPRLVLRWRYTTDALYVGRGAYVDALRVDAGGTVLFDGARPADAARIAAVGWQGSAD
>NZ_CP013219.1|WP_058079355.1|874051_874993_-|glycosyltransferase
MSAERAPDRVHRPPTAGDPRVTVAVITRDRSASLVRTLDALAALPERPPVVVVDNSRDDTTRRAVAGHPAIARLLRPAANTGALGRNLAVRHAGTPYVAFSDDDSWWEPGSLARAADLLDQHPRLGLLAARTLVGDEAAEDPLNAVLAASPLPLEPDLPGRPVLGFLGCACVVRREAFLSAGGYHPLLFFGGEETLLAYDLAAAGWGVAYEPSLRARHHPEDHDRIGRSFLVRRNHVLTTCLRRPWPVVLRAGADLALAAAAGRPGARRALKETVARFPAALARRRPLPPRVEHAAGLLDRDPAARPRRGTGR
>NZ_CP013219.1|WP_058079356.1|874982_875987_-|glycosyltransferase-family-9-protein
MTRTPIPTPRPPAVLILRALGLGDLLAGVPALRGVRRAFPGHQVVLAQPPGLTGLALETGAVDAVFPAEAPGRAVPDLGHWPGPPPDVAVDLHGNGPESRDALAALRPRRLLAHACPDGPPWPDGANERDRWCAFLHAYGIAADPLDLRLPRPATPSPAPGAVVVHPGAASGSRRWPGERFAAVVRSLRAAGHRVVLTGGPGEDDLVRSVAERGGRRGCDVLTGGLPLGELSALVAGASLVLSGDTGLAHLAVAHGTPSVTLFGPVSPRLWGPTRSPDHLALWKPGPPGDPHGRTPDARLLRIGAGEVAAACLTLLRDVRGRQRQPGPEVSHVR
>NZ_CP013219.1|WP_058079357.1|876378_877800_-|bifunctional-heptose-7-phosphate-kinase/heptose-1-phosphate-adenyltransferase
MTASQTPLVVVGDALLDHDLCGRAERLAPDAPVPVVHGTRRSSRPGGAALAACLAAADGRPVTLVTALGADAASDTLRELLSGRVGLVEVPLEGTLSSKTRVLAGDRPLLRLDDGEGRAREATQEAVSTIAAAGGVLVADYGRGTADVLRDALAHTAAPVVWDPHVRGRPPVPGVRLATPSAQEARAFARQLDDAEPGDAAGLRTAARDARALVRAWRARAVAVTLGERGALLSHGETPLLVPTPAAATGDPCGAGDRFAAAAAGLLADGALTEAAVQAAVHAATRYVAEGGARAVAVPDQPETAEEAPGDGDTTADAVRTAARVRAAGGTVVAAGGCFDLLHAGHVALLQAARRAGDCLVVCVNSDDSVRRRKGDGRPLVPAVDRVRVLRALECVDAVAVFDEDTPERILGELRPHIWAKGGDYARTRLPEQPLVESWGGQVLLLPYLDGRSTTGLARRAALTPAPTGGDAR
>NZ_CP013219.1|WP_058079358.1|877796_878774_-|SIS-domain-containing-protein
MKSRTKAVTDTAHGSTATATTHCDDLAKALEAFRDDGPLIERWGIELARRLGAGARLLVAGNGGSAAQAQHLTAELVGRYRDDRPPFSAVALHADTSSTTAIANDYGVQEVFARQTAAHGRPGDVLLLLSTSGASANLLAAADRAHRLGMTVWALTGRAPNPLQLGADDALCVDAPLGATVQELHLVAVHMLCEAFDQAVDRGEADHWTADTGADDRADADADADTGDGPGGGGERRAEAERVARGRRGLDGRPDAGGGPGAGGRPGVDGRPGVDGRPSADGGSGADGQPGVDGKPGVVGRLVGRARTVGRAAPGAPAAPRKGHT
>NZ_CP013219.1|WP_058079359.1|878770_880003_-|glycosyltransferase
MSRIPHTAGRVAMVSEHASPLAALGGPDAGGQNVYVAQVARQLARKGYRVTVYTRRDSAGLPDRVTLIDGVQVVHVPAGPPAPVPKDELLPHMPEFGDFLARQWAQSPPDVVHAHFWMSGLAALAGARDAGIPVVQTYHALGTVKKRYQGAADTSPPQRLAIEEAIGHECARIIATCSDEVAELKAMGLPEDRISVVPCGVDPDQFAPVARTRPPGARRRLLAVGRLVPRKGFDRAIRALTDVPDAELLVAGGPEADLLGTEPEAERLYGIAGEYGVQDRVTLLGGVSRARMPRLMSSADLVLSLPRYEPFGIVPLEAMACATPVVATAVGGQLDTVVDGTTGVLVPADDDYDLGAVVRALLADPDRLARYGAAGRARVLGHYTWDRVADGVAAVYGAVSSIRSLSGVVR
>NZ_CP013219.1|WP_014670870.1|879999_880962_-|glycosyltransferase
MNILVWHVHGSWLTAFVRGPHTYLVPVTDDRGPDGLGRAVTWDWPQSVRERTPRELWDCDIDLMVLQRPHELDLALRWTGRRPGVDVPAVYVEHNSPDESPERQLHPLAGQSAIPVVHVTHFNRLMWDSGQAPTEVVEHGIVDPGALYTGTERRAAVVVNEPVRRGRTTGTDLLPRFARSAPLDVFGMRTDGLAEHLGLPPERCRTRDLPQHELHREMARCRVYLHPVRWTSLGLSLLEAMFLGMPVAALDTTEAREAIPEGAGVVSNRLDVLEDAVRAFLADPGLARRTGAAARAAAQGRYGERRFLDDWERLIKEVTR
>NZ_CP013219.1|WP_014670871.1|880958_881969_-|glycosyltransferase-family-9-protein
MKSLVVRLDSFGDVLLAGPAVRAVAARSSHVTLLCGPRGADAARLLPGVDEVLVWEAPWEGFDPPPVSPADIDGLVGRLRAGAYDTALVLTSFHQSPLPTALLLRLAGVGRIGADSVDHPGRLLDVRHRRLEGRHEAEAALDTAAAMGFLPPPGDDGRLRVLPPPDTGSLTGYGPYVVLHPGASAPARAWSPHRCAEAVALLADAGHRVVVTGGPEETGLTRRVSGDLAVDLGGRTSPRTLAGVLRMADVVISANTGPAHLAAAVGTPVVSLFAPVVPAGRWAPYGVPVILLGDQSAPCAGTRALTCPVPGHPCLDEVTGQDVVRAVHKLIQERQS
>NZ_CP013219.1|WP_058079360.1|881965_882898_-|HAD-IIIA-family-hydrolase
MSRLSAVLFDRDGTLVVDVPYNGDPARVRLMPGAAAAVALARSAGLPTGVVSNQSGVGRGLLTVDQVVRVNERADELLGGLDTWVFCPHAPDAGCACRKPRPGLVHTAAARLGVPPSECLVIGDIAADVLAARAAGARGVLVPNAATAPAEVERFAMESAPDPLTAVRAALTAAGLAPPRRPPHAPPARTAPAGDRMRWSRQGPVVVSEGRWSSVRNAETPDGIRPSGRAAVVSPSRRPSAPGPAAPHRARSPVQGEAASGEARASVSGEAAAEESAASVSLSGAAAPAESPASVRVEVAVGRPLGGWSV
>NZ_CP013219.1|WP_058079361.1|882894_883890_-|glycosyltransferase
MTDAPAYTVVVPTIGRPCLAECLRALAAAEGHPPHEVVVVDDRPAPDGGLPLEPAGQLLDRVRTLRTGGRGPAAARNAGWQTVRTPWTVFLDDDVQVLPDWSRRLADDLRQAGPDVGGVQGRLRVPLPLDRRPTDWERTTKGLENAAWATADMAYRTEALKRTGGFDERFPRAFREDADLALRVQRAGWSLARGTRVTRHPVRPAHWWASLPAQRGNADDALMNRLHGRDWWDRAQAPRGRLPRHLVVTGAALAAAGCALTGRRRAATACAALWTLGTTEFALARILPGPRTAREIAGMLGTSVLIPPLAVRHWLRGAVRHRHAEPLGGAG
>NZ_CP013219.1|WP_058079363.1|885554_886562_-|NAD-dependent-epimerase/dehydratase-family-protein
MTGDTQFSWRRALVTGGAGFLGSHLCERLLDSGVEVDCADNLACGRRENIAHLEDRPGFRYTHCDVCAPDCPERLAGPYDLVLHFACPASPADYLRMPLETLDVGSLGTRNVLAIAERDGARFLLASTSEVYGDPLVHPQHEGYWGNVNPVGPRSVYDESKRFAEALVTAHAGTRGTNAGIVRLFNTYGPRMRAHDGRAVPTFICQALAGEPLTVTGDGSQTRSLCYVDDTVDGILRVAASRSVRPVNIGGSDEITVADLARRVVALTGSRSPVAFVDRPVDDPGRRRPDTTLARELLGWSPQVPWEEGLKQTIAYFAAPPPDPDPRGEEPAPRS

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Crispr_ID: NZ_CP013219_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013219_3

2588944-2589063

Orphan

Consensus_repeat	Method
GCCCCTCCCAGCCAGTCGCCCCTGGCGGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013219_3

>merge|NZ_CP013219|3|2588944-2589063|CRISPRCasFinder
GCCCCTCCCAGCCAGTCGCCCCTGGCGGCCTGCCGACACCCGGGCCTCCACGCTCGCCATCCCTCCCAGCCCGCGGGGCCCTCGCCCGCCGCCCCTCCCAGCCAGTCGCCCCTCGCGGCC

>NZ_CP013219|3|2|2588944-2589063|CRISPRCasFinder
GCCCCTCCCAGCCAGTCGCCCCTGGCGGCC	TGCCGACACCCGGGCCTCCACGCTCGCCATCCCTCCCAGCCCGCGGGGCCCTCGCCCGCC
GCCCCTCCCAGCCAGTCGCCCCTCGCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013219.1\|WP_079087988.1\|2597089_2598082_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058080316.1\|2584375_2584561_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058080312.1\|2577753_2578779_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|130256
NZ_CP013219.1\|WP_058080317.1\|2585392_2586466_-\|exo-alpha-sialidase	unknown	unknown	gnl\|CDD\|271234
NZ_CP013219.1\|WP_014672358.1\|2586581_2587178_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_014672356.1\|2584641_2585355_-\|NADPH-dependent-F420-reductase	unknown	unknown	gnl\|CDD\|273873
NZ_CP013219.1\|WP_058080314.1\|2579610_2582868_-\|AfsR/SARP-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226418
NZ_CP013219.1\|WP_058083815.1\|2593071_2593326_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_079087987.1\|2589598_2590867_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP013219.1\|WP_014672360.1\|2590867_2591101_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_014672362.1\|2592065_2592263_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058083638.1\|2587325_2588543_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NZ_CP013219.1\|WP_014672354.1\|2583582_2584386_+\|site-2-protease-family-protein	unknown	unknown	gnl\|CDD\|100079
NZ_CP013219.1\|WP_058080315.1\|2582903_2583449_-\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NZ_CP013219.1\|WP_058080313.1\|2578775_2579597_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NZ_CP013219.1\|WP_058080318.1\|2591159_2592017_+\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
NZ_CP013219.1\|WP_058080319.1\|2592389_2593079_-\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461
NZ_CP013219.1\|WP_058080320.1\|2593844_2594981_+\|EfeM/EfeO-family-lipoprotein	unknown	unknown	gnl\|CDD\|225378
NZ_CP013219.1\|WP_014672367.1\|2594997_2596254_+\|deferrochelatase/peroxidase-EfeB	unknown	unknown	gnl\|CDD\|273606
NZ_CP013219.1\|WP_014672368.1\|2596257_2597130_+\|FTR1-family-protein	unknown	unknown	gnl\|CDD\|251822

Protein	Function_ID	Function_description	E-value
NZ_CP013219.1\|WP_014672368.1\|2596257_2597130_+\|FTR1-family-protein	gnl\|CDD\|251822	pfam03239, FTR1, Iron permease FTR1 family.	6.96092e-76
NZ_CP013219.1\|WP_058080312.1\|2577753_2578779_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	8.40824e-148
NZ_CP013219.1\|WP_058080317.1\|2585392_2586466_-\|exo-alpha-sialidase	gnl\|CDD\|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	4.47848e-99
NZ_CP013219.1\|WP_014672356.1\|2584641_2585355_-\|NADPH-dependent-F420-reductase	gnl\|CDD\|273873	TIGR01915, F420-dependent_NADP_reductase, NADPH-dependent F420 reductase. This model represents a subset of a parent family described by pfam03807. Unlike the parent family, members of this family are found only in species with evidence of coenzyme F420. All members of this family are believed to act as NADPH-dependent F420 reductase. [Energy metabolism, Electron transport].	5.38681e-87
NZ_CP013219.1\|WP_058080314.1\|2579610_2582868_-\|AfsR/SARP-family-transcriptional-regulator	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	3.84772e-55
NZ_CP013219.1\|WP_079087987.1\|2589598_2590867_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.02018e-60
NZ_CP013219.1\|WP_058083638.1\|2587325_2588543_-\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	5.73759e-58
NZ_CP013219.1\|WP_014672354.1\|2583582_2584386_+\|site-2-protease-family-protein	gnl\|CDD\|100079	cd06158, S2P-M50_like_1, Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with a minimal core protein and no PDZ domains.	2.07597e-46
NZ_CP013219.1\|WP_058080315.1\|2582903_2583449_-\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	4.9847e-15
NZ_CP013219.1\|WP_058080313.1\|2578775_2579597_+\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	1.4628e-20
NZ_CP013219.1\|WP_058080318.1\|2591159_2592017_+\|type-I-methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	1.75738e-145
NZ_CP013219.1\|WP_058080319.1\|2592389_2593079_-\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	1.74553e-21
NZ_CP013219.1\|WP_058080320.1\|2593844_2594981_+\|EfeM/EfeO-family-lipoprotein	gnl\|CDD\|225378	COG2822, COG2822, Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism].	1.79115e-95
NZ_CP013219.1\|WP_014672367.1\|2594997_2596254_+\|deferrochelatase/peroxidase-EfeB	gnl\|CDD\|273606	TIGR01412, Probable_deferrochelatase/peroxidase_EfeN, Tat-translocated enzyme. This model represents a small family of proteins with a typical Tat (twin-arginine translocation) signal sequence, suggesting that the family is exported in a folded state, perhaps with a bound redox cofactor. Members of this family show homology to Dyp, a dye-decolorizing peroxidase from Geotrichum candidum that lacks any typical heme-binding site.	0

>NZ_CP013219.1|WP_058083638.1|2587325_2588543_-|IS110-family-transposase
MFDTEDVGVFLGLDVGKATHHGHGLTPAGKKVFDKPLPNSEPKLRAVFDKLAAKFGTVLVIVDQPASIGALPLTVARDAGCQVAYLPGLAMRRIADLYPGEAKTDAKDAAVIADAARTMPHTLRSLELTDEITAELTVLVGFDQDLAAEATRTSNRIRGLLTQFHPSLERVLGPRLDHQAVTWLLERHGSPAALRKAGRRRLVELIRPKAPRMAQRLIDDVFDALDEQTVVVPGTGTLDIVVPSLAASLAAVHTQRRALEAQINALLEAHPLSPVLTSMPGVGVRTAAVLLVAVGDGTNFPTAAHLASYAGLAPATKQSGTSIHGEHAPQGGNRQLKRAMFLSAFACMNADPASRTYYDKQRARGKTHTQALLRLARQRISVLFAMLRDGTFYEPRIPEDVELAA
>NZ_CP013219.1|WP_014672358.1|2586581_2587178_+|hypothetical-protein
MDAVRVALLREVLAGTEWLGATRRFAAVLRGSVVAHGGGLLLVGTPEYEPWHLAAHLVDEAAWSGTPELAPTLVRQHARPSDPAHLAVGPGRIAAARRGETLLVVAPEEPAALLERVHDARRAGVTVLALGAGGGELAAMAHDTLAVPQGAELDLDSVQHLVSAAAGENGGSPRARRGFRDRLSRLTEALTAPPPAPW
>NZ_CP013219.1|WP_058080317.1|2585392_2586466_-|exo-alpha-sialidase
MTDVTVPFRAGHEGYASFRIPAVVASGSGTLLAFCEGRVDSAADHGHIDIVLKRSTDGGRTWGPLQVAADNGANLAGNPAPVVLDTGRVLLVHVRAAATATEAAILRGRVGEADGRRVWVQHSDDDGVTWSRPREITKQVKKPGWRWYATTPGHALQLTSGRVLVPANHTLPPTGTDTGAEARYNSGHCLLSDDRGESWYLGYLDENTDGYVNVNETTAAELPDGRVYLNTRNDSPSPGNRADAHSKDGGKSLVKPFRPQAGLTAPVCQGSVLQLRDPDLLLFSAPADPAARALMTIRASDDGGTTWRPAFTVDGLPAAYSDLVRVDPRTVGLLYETGDFGAYATITFRRVPVHRLT
>NZ_CP013219.1|WP_014672356.1|2584641_2585355_-|NADPH-dependent-F420-reductase
MTSTDSAQTPAKAPAKDPWDLPDVSGYVVGVLGGTGPQGKGLAYRLARAGQKVIIGSRAAERARAAAGELGHGVEGADNAETARRSDIVIVAVPWEGHGDTLKSLREELAGKLVVDCVNPLGFDKKGAYALKPEEGSAAEQAAALLPDSRVAAAFHHLSAVLLQDPEIEQIDTDVMVLGEERADVEIVQALAGRIPGMRGVFAGRLRNAHQVESLVANLISVNRRYKAHAGLRVTDV
>NZ_CP013219.1|WP_058080316.1|2584375_2584561_-|hypothetical-protein
MPRIALYTLIVCLLAVAAAVVSFVQGSWLGIVWVLLAGLSSNMTWYYAKRGKTARNGSVTS
>NZ_CP013219.1|WP_014672354.1|2583582_2584386_+|site-2-protease-family-protein
MTTATTRHGDRQVSPVFVGILAVTAVTGWATWSGFAAQPGIAVFLFVTAAWIVSLCLHEYAHARTALHSGDITVGAKGYLTLNPLKYTHALLSIVLPVLFVIMGGIGLPGGAVFIERGRIRGRWRHSLISAAGPLTNVLFAAVCTAPFWLHALDGVPADFRFALAFLALLQVTAALLNFLPVPGLDGYGVIEPWLSYNVKRQVEPFAPFGLLFVFALLWLPSVNSAFFDVIDSIMRALNVDDFSRYCGQDLYRFWQGDNEYCAAVSS
>NZ_CP013219.1|WP_058080315.1|2582903_2583449_-|Uma2-family-endonuclease
MTIAEGWVELVQDAIHVPKSARLRLTRNGLTLVPVTYAHRATQRRIENQIEERLPGWAATSEFSVVPPREGYKPEPDATAIPLDLVETDKSDISEELLPFVVEVVSPESKNRDYNTKPSHYALRRIPAYLIVDVLAGRWTLLTRPEDGEYQHQESGVFGDQIKIPVADQTLVLDSSQFIRI
>NZ_CP013219.1|WP_058080314.1|2579610_2582868_-|AfsR/SARP-family-transcriptional-regulator
MDPVRYRLLGTTQAIRPDGTAVPVGGARLRALLSVLALRAGRTVPAGVLVDEVWGADPPADATGALQALVGRLRRALGAGAVVSADGGYRLTAAPDDVDLGRFDRLTGDGLAALADGDPAKAAAVLDDALALWRGPALADLPDRTAEAVRWETRRLDALRARHTAALALGEAERALPELTALCDSHPLDEPLQALRLRALRDTGRPAQALAAYEDVRRLLADRLGSDPGPELRVLHAELLREEPAERPAVARLGNLPARLTSFVGREADLRAIGADLSTARLVTLLGPGGAGKTRLSQEVAEAVRHTVRDGVWLAELAPVDAPDAVPQAVLTAIGARETVLHGAGVDGMRAVSDRHGDPVERLVEHCARRRMLIILDNCEHVVDAAARLTEHLLARCPELTVLATSREPLGVPGELVRPVEPLPEPVALRLLADRGAAARPGFRVEDDPEACAEICRRLDGLPLAIELAAARLRMLTPRQIADRLDDRFRLLTSGSRTVLPRQQTLRAVVDWSWDLLDAGERDVLARLSVFAGGCDLAAAEAVCGPAALDALGSLVDKSLVVAAPAADGGMRYRLLETVAEYAAERLAETGHRAEAERAHLTYYRELARTTDPLLRGSEQRAAIDRFQLEYENLRTAFRHAIAERDEQEGLCLVLSLFWFWQMRDQRIEIRTWCREVMALGPDPFTEPVRRAEPVWQRCTDAPPPYTGELLAEARRGVHLAHLACMDTEIDLWQTPEAQAKLRVVAQVYEPGLPQTCRPPGMLWFFAGLLTGGADVVRTIVDANVRTCRETPGYEWELAGALHLRANLLANRASWAGDATRDADESLEIYHRLGDAWGITEALSARGEANERKGAHREAAADYQAAIEHAERLGAHAQVAVLRARLGSVLVQAGESERGERMLRDVTADRHGAHNEAVPFARLFLAGWLSLTGRTAEAREQLRRTREEVTIARFVVFDAMITSQEAWVDAVDERTEEALTRVRRAVRLGANPLSEALNPHLNSICLTIAAMALARADGGDRAADAARCLGAADALLPPGHIPSDVERRCHALTEARIREALDPLSYEAAYAEGGGLSLAEATALF
>NZ_CP013219.1|WP_058080313.1|2578775_2579597_+|ABC-transporter-permease
MTAATLSPTVPKTDTPIPLRAHLRHTGALIRRNLLWIRQDPESMFDAILFPVVFTLLFVYVFGGSIGKSLGGGQDQYVQYVIPGLMAMMGMNMAQGVGTGFNQDFNSGVMDRFRSLPIGRGSVLFAKIAVELMRMLFATVVLLVVALLVGYDINSWSGLLASVGLSAVFGSALMWVFLTLGVVMKNAQSVQAMGFLVLMPLQFGSSIFAPTASMPGWLQAFTDYNPLSSLADTARGLMEGGPVAHDLWVTLIWSVGLTAVMAPVAIHKFRTKS
>NZ_CP013219.1|WP_058080312.1|2577753_2578779_+|ATP-binding-cassette-domain-containing-protein
MTRIDDNPVGGRSAVTVRGLVKHYGETKALDGVDLDVREGTVMGVLGPNGAGKTTLVRILSTLISPDAGQATVAGYDVVRQPRQLRRVIGLTGQYASVDEKLPGWENLYLIGRLLDLSRKDARARADELLERFSLTEAARRPAGTYSGGMRRRLDLAASMIGRPAVLYLDEPTTGLDPRTRNEVWDEVKAMVGDGVTVLLTTQYMEEAEQLASELTVVDRGKVIANGGIEELKARVGGRTLRVRPVDPLELRPLATMLDELGITGLATTTMDAETGTLLVPILSDEQLTAVVGAVTARGITVSSITTELPSLDEVFLSLTGHRAGAPQDAMPADDRQEVAV
>NZ_CP013219.1|WP_079087987.1|2589598_2590867_+|MFS-transporter
MSRALLPDLAPWKASADFRRLWKSGLISNFGSFLTFVALPVQLKDLTGSAAAVGAIGAVELLPLIVCGLYGGALADALDKRKLIVWTEAGQGLLSAALLLNALLPRPAVWPLYVVAALSSALVSVQRPALDSLWPRIVAHADMPAAASLNSLRWTVGGVAGPAVAGVVVAYAGLGWAYAADLLTFAVSLAYIARIAPSPAAEEAAKPDLKAIAEGARYAWSRKELLGTYAVDLAAMFLAMPLAVLPFLADDLHARWALGLMYATIPAGALLVSLTSGWASRVHRHGLLVALSAAGWGLAVAAAGVCGNVWLVLLFLAVGGGFDMVSGVFRAAMWNQTIPDELRGRLAGIELLSYSVGPQLGQVRAGGMAAWAGVRASVWSGGLACAGAVGLLALCLPGLMTYDARTNEHAVRMRERRAAVSA
>NZ_CP013219.1|WP_014672360.1|2590867_2591101_-|hypothetical-protein
MALFKKRTVGKPGEWYYCLEHKKVEEGPDCPGKDRFGPYASPEEARRAMETAAERNLQWENDPRWHDAPAGGGTDED
>NZ_CP013219.1|WP_058080318.1|2591159_2592017_+|type-I-methionyl-aminopeptidase
MSGQSLLVPGELSPTRSVPGNIRRPEYVGKPAPAPYTGPEVQTPETIEAMRTAGRIAAQAMAEAAKHIAPGVTTDLLDKVAHEYMCDHGAYPSTLGYRGFPKSLCTSVNEVICHGIPDSTVLNDGDIVNLDVTAYIGGVHGDNNATYLVGDVDEESRLLVERTREALDRAIKAVKPGRQINVIGRVIESYAKRFGYGVVRDFTGHGISTSFHSGLIIPHYDSPHATTVMQPGMTFTIEPMLTLGTHEYDMWDDGWTVVTKDRKRTAQFEHTLVVTETGADILTLP
>NZ_CP013219.1|WP_014672362.1|2592065_2592263_-|hypothetical-protein
MRIRSVLAATALAAALAASGATTASAAHYDTKTDDEAVCSPYAGTLTSLENHLTWSGAHCSDYLR
>NZ_CP013219.1|WP_058080319.1|2592389_2593079_-|PhzF-family-phenazine-biosynthesis-protein
MTDYDVLRVFCGPNGGYGNELGVVRDGSVLPERSDRQALAAKLGFSETVFVDDPERGVIDIYTPTVRLPFAGHPCVGTAWLLDVPELVTPAGVVGTRLDGEFTWIEARPEWAPPRTLRRYASAAEVDALDVPPPGEWIYAWAWEDEAAGRVRARAFPGRIDERGDSRPGGAGACAGGIEEDEATGAAALLLTDLLGRALNITQGKGSQLLTAPQPHGWIEVGGRVHLER
>NZ_CP013219.1|WP_058083815.1|2593071_2593326_-|hypothetical-protein
MLLWWVTALDGWLLLDGHDRAVAALAEGRTPPCVVLTRVPDEEDWRREAREVTEEARTRSWPLPGGVSAWEALAAAAMFQFPGD
>NZ_CP013219.1|WP_058080320.1|2593844_2594981_+|EfeM/EfeO-family-lipoprotein
MRAVRLTVTAAATAAALTALSACTAKSDAKDGDAIQVTAADSTCETSSTSVPAGQVTLKIENTGSKATEVEILFPDDRIVSEKENIGPGTKYTLTAEVKAGSYEIACRPGMKGHGVRQKLTVTGGGSAAKRDPKLDSAVAEYRQYAQDQADETLPKAETFVKAVKDGDLEAAKKSYGLSRLGWERTEPVAESFGDIDPKVDVREDGLEAGQKWTGWHRLEKALWHDKKIGAEEKALADRLLTDLKDWQGRVGKAEITPTSMANGAKELLDEVATGKVTGEEDRYAHTDLVDFKGNVEGAQKAYELLKPVASKNDPALTEELDKQFAALDALLDKYRTDKTSYDFVSYDKVTKDQRKELSDAVNALAEPLSKLAAAVVK
>NZ_CP013219.1|WP_014672367.1|2594997_2596254_+|deferrochelatase/peroxidase-EfeB
MTETQETRANPSRRALIGWGGAGLALGAAAAGGAVAMARTGDDMDPAAAETGGAVEFHGVHQAGIATPVQDRLHFAAFDVKTDDREAFVQMLKDWTAAARRMTAGKTVGEGAYGGLAEAPPDDTGEALGLKPSRLTLTIGFGPSLFDKFDLADRRPEALVDLPKFPGDNLDRSRTGGDLCVQACSDDPQVAVHAIRNLARIGFGKVAIRWSQLGFGKTSSTTPDAQTPRNLMGFKDGTRNIAGTETDRLDKFVWVGEEDGPDWMTGGSYLVARRIRMNIETWDRASLQEQEDVFGRDKREGAPVGKAKEHDEPFLKAMKPDAHVRLAHPDSNNGITILRRGYSFTDGTDGLGRLDAGLFFLAYQRDVRKGFIPLQRRLAAHDALNEYIQHVGSAVFAVPPGVRDSGDWWGRTLFSKGA
>NZ_CP013219.1|WP_014672368.1|2596257_2597130_+|FTR1-family-protein
MFSNYLIGLREGLEASLVVCILIAYLVKTGRKDALRPIWIGIGIAIAIAMGFGCALEFGSQELTFQAQEALGGSLSVVAVGLVTWMVFWMRRTARHLKSELHGKLDAALALGTGALVATAFLAVGREGLETALFVWASVHAASDGTPRPLIGVALGLATAVLLGWLFYRGALKINLAKFFTWTGGMLVVVAAGVLAYGFHDLQEADWIPGLNDLAFDISGVIPPDSWYGTLLKGVFNFQPDPTVLQITVWALYLVPVLALFLSPVGFASGKGKVKEPDDQGTQPSAASQA
>NZ_CP013219.1|WP_079087988.1|2597089_2598082_+|hypothetical-protein
MTRERSRQRLRRRDRNALIAASLTALSLTASGCVVVHGERVVLPAATRAEAAKAVSAFTDAYNKADKAYDSSLDAPYVTGALSDIDSARLRAGHVNSPSGNANHTPLTLTDVKITIPEKAGWPRWFVADARGNKGGNYRWVLVFTRGDLGERWQVSYLTLMAPGTVPAFKTDEDGWAEAVPAGAGGLAVRPDELSKTYADYLKNGGKAFADGRDTSGLRADRAKEAKKPGLVRQFIDEPLTHGDYAPLALRTADGGALVFFTTHHYEKQTAYTGATVPVPNKDVRALIKGDVKQSLTLESIANQAVLDPAGSGPVRMLGRVQGLTSAQGA

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Crispr_ID: NZ_CP013219_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013219_4

2631303-2631391

Orphan

Consensus_repeat	Method
GGGGGACTCGGGGCGCTGCTCGCCGGGAG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_CP013219_4

>merge|NZ_CP013219|4|2631303-2631391|CRISPRCasFinder
GGGGGACTCGGGGCGCTGCTCGCCGGGAGCTTGCCCGGCGCGGGGGGCCTGCCCGGCGCTGGGAGCCGTGGGGTGCTGCTCGCTGGGGG

>NZ_CP013219|4|3|2631303-2631391|CRISPRCasFinder
GGGGGACTCGGGGCGCTGCTCGCCGGGAG	CTTGCCCGGCGCGGGGGGCCTGCCCGGCGCT
GGGAGCCGTGGGGTGCTGCTCGCTGGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013219.1\|WP_058080340.1\|2626590_2627439_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP013219.1\|WP_014672403.1\|2641755_2642580_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058080336.1\|2622361_2623771_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226984
NZ_CP013219.1\|WP_058080349.1\|2639960_2640578_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173776
NZ_CP013219.1\|WP_058080334.1\|2614614_2615028_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|366361
NZ_CP013219.1\|WP_058080345.1\|2632789_2633701_-\|Nif3-like-dinuclear-metal-center-hexameric-protein	unknown	unknown	gnl\|CDD\|376614
NZ_CP013219.1\|WP_058080337.1\|2623767_2624403_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058080348.1\|2638034_2639615_-\|alpha-N-arabinofuranosidase	unknown	unknown	gnl\|CDD\|370363
NZ_CP013219.1\|WP_107112980.1\|2618566_2622208_-\|BREX-2-system-adenine-specific-DNA-methyltransferase-PglX	unknown	unknown	gnl\|CDD\|380293
NZ_CP013219.1\|WP_058080341.1\|2627547_2628981_-\|RNB-domain-containing-ribonuclease	unknown	unknown	gnl\|CDD\|223631
NZ_CP013219.1\|WP_078611962.1\|2632049_2632793_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224495
NZ_CP013219.1\|WP_058083819.1\|2635514_2636372_-\|3-alpha,7-alpha,-12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|178455
NZ_CP013219.1\|WP_058080346.1\|2633888_2635190_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058080347.1\|2636716_2638069_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP013219.1\|WP_058080335.1\|2615383_2618458_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|372468
NZ_CP013219.1\|WP_058080343.1\|2629910_2630573_+\|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	unknown	unknown	gnl\|CDD\|235577
NZ_CP013219.1\|WP_014672404.1\|2642576_2643116_-\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP013219.1\|WP_058080342.1\|2629055_2629838_+\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|234999
NZ_CP013219.1\|WP_058080350.1\|2643436_2645179_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341047
NZ_CP013219.1\|WP_058080333.1\|2613532_2614522_-\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253

Protein	Function_ID	Function_description	E-value
NZ_CP013219.1\|WP_058080340.1\|2626590_2627439_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	3.89212e-26
NZ_CP013219.1\|WP_058080336.1\|2622361_2623771_+\|AAA-family-ATPase	gnl\|CDD\|226984	COG4637, COG4637, Predicted ATPase [General function prediction only].	3.51573e-22
NZ_CP013219.1\|WP_058080349.1\|2639960_2640578_-\|hypothetical-protein	gnl\|CDD\|173776	cd01026, TOPRIM_OLD, TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as RNase activity, consists of an N-terminal ABC-type ATPase domain and a C-terminal Toprim domain; the nuclease activity of OLD is stimulated by ATP, though the ATPase activity is not DNA-dependent. Functional details on OLD are scant and further experimentation is required to define the relationship between the ATPase and Toprim nuclease domains. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general acid in strand cleavage by nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.	9.05519e-07
NZ_CP013219.1\|WP_058080334.1\|2614614_2615028_+\|VOC-family-protein	gnl\|CDD\|366361	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	2.03315e-13
NZ_CP013219.1\|WP_058080345.1\|2632789_2633701_-\|Nif3-like-dinuclear-metal-center-hexameric-protein	gnl\|CDD\|376614	pfam01784, NIF3, NIF3 (NGG1p interacting factor 3). This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.	5.03792e-83
NZ_CP013219.1\|WP_058080348.1\|2638034_2639615_-\|alpha-N-arabinofuranosidase	gnl\|CDD\|370363	pfam09206, ArabFuran-catal, Alpha-L-arabinofuranosidase B, catalytic. Members of this family, which are present in fungal alpha-L-arabinofuranosidase B, adopt a beta-sandwich fold similar to that of Concanavalin A-like lectins/glucanase. The beta-sandwich fold consists of two anti-parallel beta-sheets with seven and and six strands, respectively. In addition, there are four helices outside of the beta-strands. The beta-sandwich strands are closely packed and curved with a jelly roll topology, creating a small catalytic pocket. The domain catalyzes the hydrolysis of alpha-1,2-, alpha-1,3- and alpha-1,5-L-arabinofuranosidic bonds in L-arabinose-containing hemicelluloses such as arabinoxylan and L-arabinan.	0
NZ_CP013219.1\|WP_107112980.1\|2618566_2622208_-\|BREX-2-system-adenine-specific-DNA-methyltransferase-PglX	gnl\|CDD\|380293	NF033451, BREX_2_MTaseX, BREX-2 system adenine-specific DNA-methyltransferase PglX. This protein, PglX, is a site-specific DNA methyltransferase associated with PGL (phage growth limitation), a type 2 BREX (bacteriophage exclusion) system. The phage resistance appears not be restriction, but does manage to inhibit phage replication.	0
NZ_CP013219.1\|WP_058080341.1\|2627547_2628981_-\|RNB-domain-containing-ribonuclease	gnl\|CDD\|223631	COG0557, VacB, Exoribonuclease R [Transcription].	6.61913e-81
NZ_CP013219.1\|WP_078611962.1\|2632049_2632793_-\|hypothetical-protein	gnl\|CDD\|224495	COG1579, COG1579, Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only].	3.6303e-26
NZ_CP013219.1\|WP_058083819.1\|2635514_2636372_-\|3-alpha,7-alpha,-12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA-hydratase	gnl\|CDD\|178455	PLN02864, PLN02864, enoyl-CoA hydratase.	5.94026e-70
NZ_CP013219.1\|WP_058080347.1\|2636716_2638069_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.64067e-47
NZ_CP013219.1\|WP_058080335.1\|2615383_2618458_-\|AAA-family-ATPase	gnl\|CDD\|372468	pfam13087, AAA_12, AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	1.74448e-25
NZ_CP013219.1\|WP_058080343.1\|2629910_2630573_+\|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	gnl\|CDD\|235577	PRK05718, PRK05718, keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional.	6.88003e-93
NZ_CP013219.1\|WP_014672404.1\|2642576_2643116_-\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	7.44217e-51
NZ_CP013219.1\|WP_058080342.1\|2629055_2629838_+\|peroxide-stress-protein-YaaA	gnl\|CDD\|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	8.60333e-74
NZ_CP013219.1\|WP_058080350.1\|2643436_2645179_+\|MFS-transporter	gnl\|CDD\|341047	cd17504, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.4248e-72
NZ_CP013219.1\|WP_058080333.1\|2613532_2614522_-\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.73873e-47

>NZ_CP013219.1|WP_058080343.1|2629910_2630573_+|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase
MTSPLPPFPAASVLDLAPVVPVVVLTDAADAVPLARALVAGGLPAIEVTLRTPAASAAIRAIAAEVPEAVVGAGTVITPEQVDACTADGARFLVSPGWTEALLEAMRGSGVPFLPGVSTTSEVVALLERGVREMKFFPAQAAGGTAYLSSLAGPLPQARFCPTGGIGPKTAPEYLALPNVGCVGGSWMVPADAVAARDWGRIEELARTAAGLRSSDGSGA
>NZ_CP013219.1|WP_058080342.1|2629055_2629838_+|peroxide-stress-protein-YaaA
MLVLLPPSEGKANAGEGAPLRLESLSLPGLTAAREAVLGELVELCSADEEKAREVLGLSEGLRGEVAKNAGLRTAGARPAGEVYTGVLYDALGLATLDAAARRRAADSLLVFSGLWGAVRVTDRIPSYRCSMGVKLPGLGALAGHWRAPMAEVLPEAAAGGLVLDLRSSAYAAAWRPKGEVAGRTATVRVLHAPTRKVVSHFNKATKGRIVRGLLTAGAAPRDPAELVEVLRELGYVVEAEAPGKAGKAWALDVLVDEIH
>NZ_CP013219.1|WP_058080341.1|2627547_2628981_-|RNB-domain-containing-ribonuclease
MPRRKIHVTGAPEAPLRAALAALRSELGIPEDFPPEVHAAAEQAAKDPALPVYDATDIPFFTLDPPTSTDLDQATHLSRQGTGYRVRYAIADVAAFVAPGGALDAEAHRRVTTLYFPDERVPLHPTVLSEGAASLLPGRTRPAVLWTIDLDAEGRTRAVDVRRALVRSRAKLDYAHVQRDIDKGTAEEPVALLKEIGEARERLEAERGGISLDVPEQEIVEQDHTYALRYRAPLPADRWNAQLSLLTGMAAADLMLAHGAGILRTLPTAPDGAVARLRRTATALHIDWPHHVSYAALLRTLDPHDPHHAAFLQECTTLLRGAGYTVFQDGRLPGLTTHAAVAAAYAHCTAPLRRLADRYASEICLAAVAGQDPPDWVLAALDALPRRMADGSRRAGTVERECVDIVEAALLKDRIGDVFDGCVVDVDEHRPNVGTVQVLSPAVIGRVEGTDLPLGERLRVRLTRADPGTSKILFTVA
>NZ_CP013219.1|WP_058080340.1|2626590_2627439_-|AraC-family-transcriptional-regulator
MGEQARWTRAKLGRCGPPLDLLTASFRRHVYAPHAHDEYTIGVCVGGSEIIDYRGGRIRTGPGTIVVLEPGEMHTGGPGNPTDGYAYRALYAEPSLLADGTLGGLPHFREPLVDDPALAEALRTAHTRLSACPDPLEAESVLPWVLTALARRHSTARPLADRVPGADAIARTVRDRLADELTDPPSLALLATDLGLSRYQLLRAFRTTMGIPPCAWLAQHRVTKARVLLENGLRPAEVAGLVGFADQAHLTRWFRRVLGVTPAAYRNSVQDSPGPGGRHSAA
>NZ_CP013219.1|WP_058080337.1|2623767_2624403_+|hypothetical-protein
MTVRALYLCEGSSDTGLSDHIKEIGAEMGREILVTPPDLDRLPDKPGHSVRDKLRAAQRLSDEWQVYDLVVIHRDSDGNPPERRRTEIAEAVTEVCPGLVHVPVIPVRMLEAWLLLNQQAIREVAGNPNGKVALDLPKATRAESVPDPKALLKQAIATASEDKGRRLEKLQKRFPENRARLLQMLDRAGPVQQLASWQAFTQDLREALNSL
>NZ_CP013219.1|WP_058080336.1|2622361_2623771_+|AAA-family-ATPase
MLTRLEVSGFKNLLDLNVEFGPFTCIAGENGTGKSNVFDAIQFLSLLTDHSMIEAAQAVRGTHGALHGDARDLFWNGYSDGEHRMEFAAEMIVPSEVEDDFGRLAEPTATFLRYDLHLGYQPPQGGERSGRLTLLREDLNQIRSSDAASHLRFSPARAFRSSVVRGRRSAPYISTSLETGEPVILVHADGSRKGKPRPAPGRRAAKTLLSSINLNDDPTILAARREMQSWRRLALEPSALRTSDNYRDPSEMQPDGLHLPRSLDRIARERFPDDPARVYSRVAGRLSDLSGLHVKTLHVEADDTRELLTIKLHEIDGMVLPARSLSEGTLRFLALCVLLEDPQAHGLLCMEEPENGIHPANLSAMVELVRDLAVDPSVPVDEDNPFRQVLINTHSPGVVQLVDAPDLLIADTASIPQGTGKAARGLRLRPLAGTWRASGAEKGYGTKADILAYLTSPPGARLTLAESAS
>NZ_CP013219.1|WP_107112980.1|2618566_2622208_-|BREX-2-system-adenine-specific-DNA-methyltransferase-PglX
MYGGEVAAVPPTRGADTGTPSLDREALLSGLRRQLRILETDLRERSDNVDQYRDRLRGAYEQERAEGRTAATYGAWRDERIMQVAVAWVLGTVFVRYCEDNDLISRPFIAGPGGRLAEAEERQRTYLAQHEEAQDRDWLVEAVTHLAWSHPVMDRIFDREHSPLWQLPPSPRAATGLVVFWRQRDEDGSLRFDFTDPQLDTRFLGDLYQDISEGARQAYALVQTPEFIEEFILDLTADPAIAIFGLKGFRSIDPACGSGVFLLGLFGRLLNAWRTVEPGTTDDELIRRALKSVHGCDVNPFAVNITRFRLLMAAVQASGRRRLLRQVPGWEVNVAAGDALLEGRGAPRELLHTTGDVAEFSASCDLLGVNSYHVVVGEPPYISVYDEMRRAAYRGAYDVAVGVFPLSLLFVERMFRLAVSKNEVTPGGYVGEYTSSSFTKRGFGEKLIEDFLPRVGLTHVIDTSGAYVPGHGTPTLILVGRNDSTMRDAPVRALFSVHGEPTEPEQPAQADQGIVWQSILAQIDRPGSSSEWVSVEDEPRHRFSRFPWPMVGGGAADLMDRLSGSPRRLTDVLSGPVGAGSAPGELDVFELGRPWFDRHADASGLSLGLVTGEVVRDWRAEAATEVLAPYDGNGSPLPLNLSSSWGRHLWTMRQVLRTASGRRESSQTRPWWTWRRRLPERHQGPVITFAAVASHNHFAQADDAEAFSRTAPVLRLPADASEDTYVGLLGVLNSSTACFWLKQTSPDKGNAGVTLSSAGKEWARTYSFTAKSLLQLPLPSDAPRARSRELTRLARLLDAQQPSTVFTDRRPPSRKALNAARAAYARTRHEMVALQEELDWDVYASYGLLSADERARLITSPDCELPTLRPGERAFEIVWARKVAEGTASPSWLEGPSWFDRHEVTLVTDVPNHWPAAYRDVVRARIDAIESRQAIALVERAEYKRRWATEPWEKSEERALRTWLLDRCEDERLWFEEKNGDRRPRPRTIGQLARELGDDARVRSAAALYAADHLGRREGTLADVLAAILDGEQVPYAAALTYKESGLRKRAQWERVWELQRREDETGEALGIPVPPKYVSADFQRASYWSIRGRLDIPRERFISYADVVDEGGGLLLGWSGWNETDRVRVLLDLVGAVGRQPNPSVYRITSLLAGVQELLRSMRRWEVQEYSMGRLGQFEVFQRHFEDLLSVYGLTTHDLTSWRPRRSAPKHP
>NZ_CP013219.1|WP_058080335.1|2615383_2618458_-|AAA-family-ATPase
MTGAERHHLVAELMRAARLEVAAELRSDGGNGPKASLREGRRTSGAGEGYEYEFECKRWPDALNGKPLLIRASRSRGSWAPVEAAPLSGQKIRVVTEADLGPNPAQVQLRVDDSATWRVLAERLATVGEEDHPVRLESAGWMIGLGSPKVAHDADPGRWVANWPSLKLNSRQRQAVEQALASEITFLWGPPGTGKTDVIAHIVEGSCRQGLNVLFLAPTKVAVDQALERICDLLAGENGFGAGLVQRAGDIDVESLRDRYGEYVEPERIAARLSEQLQSQLTEWNATLTAVRAGIALYDRTRGLEEGLATARTAYERAGKAAHSARQAFDQAQIAAGQLALRIKDMGQPTGWRAERKQAKLDAALSDFQAAGQQVSEAKRAENAAEAAQRKALADITRIRADITQLTPGLTGLPPRPDLVKQADAVQQSIDAAEAELRRITDAVRRNCRVLGTTVAKAVQSRPLLQRTDVVVIDEAGMVDLPSAWYVGGLAGKRVVVAGDFRQLPAITKAVEDRAATPDDRAHARRWSATDAFRAAGLVSPAGTVLQQPRLVALNTQYRMRPSICALVNAVAYPDAPLTTGRDDTSRIPFNTLVDAPIMMIDTSRHRVPGPSHLSNPVHTAVVHELVRGLQYDGVLPGRKWQNVPPGERAADRLAVITPYKDQVKALGQTLTERFGAEHEGLVATVHRFQGSQRPVVVLDTAAGSGDRLGRFYEETGLDSQTCRLLNVALSRAQDHLVVIADVEFLRLKLPARSEARVMLDHLEAHAQTLSVDQLIPIRSAADLAKLPQEELTRPAFFPADQVDRAVRWDIERAATRIDIYTFLLSPTRVRQWAKPFAERAAAGVEIVIHTRSPQEQRDPSGAERHQSLVDQLKSYGCTVTYRERMHEKVFMVDDTVLWHGSLNLLAAMGPTDLMMRLEDPESCAQARKVMEQARMERSVYQPRNESRRTRKEGPGGGKNPGKEEGVEVGAVVWGRLYLNVPYRYKDEAKSQLNASWDEDNKLWYVDAGRTSRDKLQRWLRPKH
>NZ_CP013219.1|WP_058080334.1|2614614_2615028_+|VOC-family-protein
MDFVSIRIITGDVARLVEFYERATGARATWANEDFAELRTAGATLAIGSTRTVPLFAPGSARAADNHSVITEFLVDDVDSVYDNLTGFVTDFVTKPTTMPWGNRSLLFRDPDGNLVNFFTPVTPTAIERFARATAAR
>NZ_CP013219.1|WP_058080333.1|2613532_2614522_-|YafY-family-transcriptional-regulator
MPRPTGRVLTLLELLQAGGTRTVAELADRLGVEGRTVRRYVDQLIDLDVPVESVRGRYGGYRLAPGYRLPPLMLSDDEALAVLLGLVAGRRAGLTTTERTANETASAKIRRVLPKHIARRLDTLLEALAFTDQPGEFDTPDAGVLLTVADAVRHRRPVSIRYTDRDGRPSERTLHAYGIVAHAGRWYVTGKDARIGEDRTFRLDRIADARTLPGSFEAPVGPAPAQRVLSGFATAGYRHEVTLRIHGTVEQIRAHLPVSVASLEEHEPAAGEDRATERWLRVELRVERLDWLPPVLASLGRPFVIERPDELRDLVIALADRLTSSARRA
>NZ_CP013219.1|WP_078611962.1|2632049_2632793_-|hypothetical-protein
MNAAPADQIRLLDVQALDVRLQQLAHKRRSLPEHAEIESLTKDLTQLRDLLVAAQTEESDCAREQTKAEQDVDQVRQRAARDQQRLDSGAVTSPKDLSNLQHEIASLAKRQGDLEDVVLEVMERREAAQERVNELTERVASVQSKIDDATGRRDAAFEQIDGEAASVTKEREVVAASVPADLLKLYDKLREQQGGIGAAKLYARTCQGCRQELAITELNEIRAAAPDTVVRCENCRRILVRTAESGL
>NZ_CP013219.1|WP_058080345.1|2632789_2633701_-|Nif3-like-dinuclear-metal-center-hexameric-protein
MPRLSEVIAALENLWPAERAESWDAVGTVVGDPAQEVTRVLFAVDPVQEIVDEAVRLGADLLVTHHPLYLRGTTTVAATHFKGRVVHTLIKNDIALHVAHTNADTADPGVSDALAGALDLRVVRPLVPDPADSEGRRGLGRVCELDHPLTVRELAARAAERLPATAQGIRVAGDPEAVVRTIAVSGGSGDSLFDQVRAAGVDAFLTADLRHHPASEAVAAHSPLALLDAAHWATEWPWCELAASQLDEISDRHGWDLRVHVSKTVTDPWTAHAASPATAHPSPTTTLPTSASRAPSDTTGAPN
>NZ_CP013219.1|WP_058080346.1|2633888_2635190_+|hypothetical-protein
MTVCAIEPPSTDGAADVPGTGCAITADGAYAARLARDGDSWFPERWTLDGPEPYAVPLPGNQPEGPGTEVQPMGDGRVLIHRPVAGRHAFSLLYPTGPGTGELPLGAVECAGPGTRLTLLPPAPGGVRAYALAVGPRSSVVWLVAGGAFGPQRCAEVPGRCSGGVWLDGSGRLLALDRELDGRTKTVVVDLERAGEVSPLLQIAEGSDDRLLLADPDSGLLLISSDAPSPGRERLGWGVLGSTLPVRFPECLRVPECVVTPFAIQPGQVLMPENCAVGLRIDGSLGTWVGVWRPAGREVRHLPAPEGWLAGTGLCTRDGVLRLPYATEATPCGVSDVPAPGGVAAPAPAGLGDAAREGTGNVAGEGTGSVAAERTGGVAAERTGDAQGPDPDGGAAGAFERVGPVGAEPGPPVPAAARPVPLQQAPLGRLVTN
>NZ_CP013219.1|WP_058083819.1|2635514_2636372_-|3-alpha,7-alpha,-12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA-hydratase
MPIDAAKALAAEPRSGEISWTRKDVLLYHLGIGAGVPATDPDELRYTLESRLHVLPSFATVAGAGSPGVISGLSMPGVDVDLARVLHGGQTLTLHRPLPAEGTATATGRIAAVYDKGSAAVLVMRTDVADSEGPLWTNDAQIFVRGEGGWGGDRGPSARREAPTGEPDRVVERRLREDQALLYRLSGDWNPLHADPEFAKLAGFERPILHGLCTYGVTLKAVVDTLLGGDVSRVRSYATRFAGVVYPGETLRIRMWASEASVRAAVSAVERDDAPVLADTIVQHS
>NZ_CP013219.1|WP_058080347.1|2636716_2638069_+|sensor-histidine-kinase
MAAWQRERPVWRADPRRSRAARRAARCEGADPSAAGHPGPPPTGFTLLPWLLLGMGSLSNVLQGETPNPWIGGLGLLAFNSLYVYVTFRAFDRSRRESASTRVALGLLGLVTTGLALGYGGNWLMFFPLLGLATGATLRGPWLGRVGLLLTLYAGAATWLRDGWDDASGIAYATFLSSMVTAAILSLSEAVRELRAAREELARRAVAEERLRFSRDLHDLLGHTLSVVVVKSEAARRLAPRDLDAALAQVSDIESVGRQALTEIREAVTGYREGSLATELTRARSALSAASVQPVVRQSGAPLAPQTEALLGWVVREAVTNVVRHSRADRCEITVEGAADRVRLTVADNGTGAGTPAAGAGAGGTGLTGLTERLAAAGGSLTAGPAPRGGFTVTADLPVSGDLPAGGDLPAGGAEWATAVGTGAGAGTGAGAATTDAAAVTAPRARRPPS
>NZ_CP013219.1|WP_058080348.1|2638034_2639615_-|alpha-N-arabinofuranosidase
MLTRTPRAPGAPRAARTPRALLSLLAVCATLAALFLGTGAPPAAAASSLPCDLYAAAGTPCVAAHSLVRALYASYNGPLYQVQRAKDGAKTNIGPLSAGGYADAAAQDSFCAGTTCVITEIYDQSPRHNDLTIEGAGGAGAADVGAPADALPVTAGGHQVYGLEISAGMGYRDNSTSGVAVNGQAEGMYMVTSGTHVNNRCCFDYGNAETNNMDTGNGHMDAINFGTECWFSPCYGQGPWVQADLENGLFQSDAGHSRNTSNTGTGPLPFVTALLKNNGQDHFALKYGNAQSGGLTTTYSGGEPTAGGYKPMHQEGAIVLGTGGDNSNGSIGSFFEGVMTAGIPTDAADNAVQADIVSVGYGGPTGSTGTLSPGSETSLRATTSCCTGDYVRHQNDAAVISPVTSGSSSLDKNDATWIVRRGLADSSCVSFESRNYPGDFLRHSNYRVYRQPMDGTAQFRADATFCPQTGKSGTGTSFASYNYPTRYLRHYDHTLYIASNGGANAFDSSTSWTADVSWAVAAPWAP
>NZ_CP013219.1|WP_058080349.1|2639960_2640578_-|hypothetical-protein
MADMGAFREAVTAWAAGGPGAPARELAARLSVRAAVLLEGPSDEAAVGALAAGRGRDLEAEGVCVLPMGGAMNVGRFAGLLGPAGLGLRLTGLCDERERPYYARGWERAGAAQHGFFVCAADLEDELIRALGVTRVAELVRAEGDLRALKTFLRQPAQRGRTAQQQLRRFLGTKKGRKIHYGRVLVEALDPDRTPAPLDGLLTSL
>NZ_CP013219.1|WP_014672403.1|2641755_2642580_-|hypothetical-protein
MMSADRENHDMTQTDIALLLADAADEVEIGIAPVQAVIRGGRRRRARRWAVAAATALVLAGSTGATLAFAGLPGERAGRGTPTAPGPASAEERHVYAPQRTELARGTEQGKQWRVWVEVWGAPRDAREADRQFDAMKAVGLRPAVDRAADLVGKTSYFSMRSYGGGRSLVVMFDTHQRIDRLSGTDLMAAAVSLEEPSPTAPERLVVGHVAKSAREVTCRWKDGGSTVARPAGSAPAAHDGTALIRPVAGYPGGNWFVCVAPEGTAYENADVTK
>NZ_CP013219.1|WP_014672404.1|2642576_2643116_-|SigE-family-RNA-polymerase-sigma-factor
MGDGKQTRNEEFQSFVVGRWPRLMRTAFLLTGEQHAAEDLVQSTLEQVYVAWRRVGGADDPEAYVRRVMINAHARRHRRRLREFLAPKDDSGLVREVADTGDLIAQADDRSALLKALAQLPVRQREAVVLRYWEDLTETQTAEAMGCSVGTVKSNAAKGIAKLRAIPGLADMVTHGGRK
>NZ_CP013219.1|WP_058080350.1|2643436_2645179_+|MFS-transporter
MPETTTDQPTRIAGGAVVPVLAFAGIVVAVMQTLLVPVIKDLPQLLDTAPSNATWVLTSTLLSGAVATPIMGRLGDLYGKRRMLVLSLAVMVVGALVSAFTDQLLTMIVGRTLQGFAMGAIPLGIGLMRDMLPREKLGSAMALMSSSIGVGGGLALPAAALVAQHTDWHALFYGAAGLGALAILLTFLVVPESPMRAAGSFDLLGALGLSAGLVLLLLPITKGSDWGWSSGTTLGLFAAAVVVLLLWGLYELRVQAPLVDLRTTARREVLLTNLASIMVGVSFYVVSLVLPQLLQLPTATGYGLGQSMVVAGLCVAPLGLTMMFTAPVYARLSARYGPKFTLITGLVVIAIGYGGGLGLMDAAWQTIITSVILGAGIGLAYSSLPALIVGAVPASETGAANGLNTLMRSIGTSVSSAVIGMVLANTANNVNGVAVPTMHGFRVSFLIATAAVAVGLVLAVFLPKAARPAQHTQLRASSEEEANLERAEEVLRGFRGRILDAGGAPVARAKVTLIDRRGRQAGATVSAEDGSYALAVPAQGAYVLAARALGHGPLASLATHSGEERTVALDLSLPGEAVNA

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Crispr_ID: NZ_CP013219_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013219_5

2856756-2856865

Orphan

Consensus_repeat	Method
CCGGCCACCCGCCCACCGCGACCGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013219_5

>merge|NZ_CP013219|5|2856756-2856865|CRISPRCasFinder
CCGGCCACCCGCCCACCGCGACCGCCGTCGAATGGCGCCGCCACGGCCCCTGCCCGCCGCAACCAACACCCGGCACCCGCACCCCGGCCACCCTCCCACCGCGACCGCCG

>NZ_CP013219|5|4|2856756-2856865|CRISPRCasFinder
CCGGCCACCCGCCCACCGCGACCGCCG	TCGAATGGCGCCGCCACGGCCCCTGCCCGCCGCAACCAACACCCGGCACCCGCACC
CCGGCCACCCTCCCACCGCGACCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013219.1\|WP_058080471.1\|2858705_2859302_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP013219.1\|WP_058080473.1\|2860740_2861445_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379235
NZ_CP013219.1\|WP_058080464.1\|2848712_2850059_-\|acyl--CoA-ligase	unknown	unknown	gnl\|CDD\|341228
NZ_CP013219.1\|WP_058080466.1\|2851286_2852141_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293835
NZ_CP013219.1\|WP_058080463.1\|2847936_2848716_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187594
NZ_CP013219.1\|WP_014672605.1\|2856960_2857713_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP013219.1\|WP_014672596.1\|2847661_2847943_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058080472.1\|2859478_2860492_+\|gamma-butyrolactone-biosynthesis-enzyme	unknown	unknown	gnl\|CDD\|367638
NZ_CP013219.1\|WP_058080468.1\|2853910_2854333_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP013219.1\|WP_058080478.1\|2866251_2868249_+\|dipeptide/oligopeptide/nickel-ABC-transporter-permease/ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP013219.1\|WP_058080475.1\|2862254_2863409_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225052
NZ_CP013219.1\|WP_014672603.1\|2854391_2855315_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319
NZ_CP013219.1\|WP_058080467.1\|2852219_2853665_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP013219.1\|WP_058080474.1\|2861536_2862136_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379235
NZ_CP013219.1\|WP_058080465.1\|2850055_2850853_-\|HAD-IB-family-hydrolase	unknown	unknown	gnl\|CDD\|319796
NZ_CP013219.1\|WP_058080462.1\|2846627_2847659_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368545
NZ_CP013219.1\|WP_058080469.1\|2855651_2856281_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP013219.1\|WP_058080470.1\|2857788_2858709_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187578
NZ_CP013219.1\|WP_058080476.1\|2863653_2865291_+\|twin-arginine-translocation-signal-domain-containing-protein	unknown	unknown	gnl\|CDD\|173853
NZ_CP013219.1\|WP_058080477.1\|2865295_2866252_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674

Protein	Function_ID	Function_description	E-value
NZ_CP013219.1\|WP_058080471.1\|2858705_2859302_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.14415e-09
NZ_CP013219.1\|WP_058080473.1\|2860740_2861445_+\|AAA-family-ATPase	gnl\|CDD\|379235	pfam13521, AAA_28, AAA domain.	3.48476e-07
NZ_CP013219.1\|WP_058080464.1\|2848712_2850059_-\|acyl--CoA-ligase	gnl\|CDD\|341228	cd04433, AFD_class_I, Adenylate forming domain, Class I, also known as the ANL superfamily. This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.	1.29455e-68
NZ_CP013219.1\|WP_058080466.1\|2851286_2852141_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293835	cd16277, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	7.74772e-51
NZ_CP013219.1\|WP_058080463.1\|2847936_2848716_-\|SDR-family-oxidoreductase	gnl\|CDD\|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	2.03391e-68
NZ_CP013219.1\|WP_014672605.1\|2856960_2857713_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.77031e-72
NZ_CP013219.1\|WP_058080472.1\|2859478_2860492_+\|gamma-butyrolactone-biosynthesis-enzyme	gnl\|CDD\|367638	pfam03756, AfsA, A-factor biosynthesis hotdog domain. The AfsA family are key enzymes in A-factor biosynthesis, which is essential for streptomycin production and resistance. This domain is distantly related to the thioester dehydratase FabZ family and therefore has a HotDog domain.	4.6112e-14
NZ_CP013219.1\|WP_058080468.1\|2853910_2854333_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.10192e-17
NZ_CP013219.1\|WP_058080478.1\|2866251_2868249_+\|dipeptide/oligopeptide/nickel-ABC-transporter-permease/ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	9.76103e-129
NZ_CP013219.1\|WP_058080475.1\|2862254_2863409_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|225052	COG2141, COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion].	5.23209e-45
NZ_CP013219.1\|WP_014672603.1\|2854391_2855315_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	9.06337e-35
NZ_CP013219.1\|WP_058080467.1\|2852219_2853665_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.17888e-51
NZ_CP013219.1\|WP_058080474.1\|2861536_2862136_+\|ATP-binding-protein	gnl\|CDD\|379235	pfam13521, AAA_28, AAA domain.	5.44348e-12
NZ_CP013219.1\|WP_058080465.1\|2850055_2850853_-\|HAD-IB-family-hydrolase	gnl\|CDD\|319796	cd02612, HAD_PGPPase, phosphatidylglycerol-phosphate phosphatase, similar to Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C. This family includes Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C, PgpC (previously named yfhB) which catalyzes the dephosphorylation of phosphatidylglycerol-phosphate (PGP) to phosphatidylglycerol (PG). This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.25896e-44
NZ_CP013219.1\|WP_058080462.1\|2846627_2847659_-\|hypothetical-protein	gnl\|CDD\|368545	pfam05655, AvrD, Pseudomonas avirulence D protein (AvrD). This family consists of several avirulence D (AvrD) proteins primarily found in Pseudomonas syringae.	5.2899e-158
NZ_CP013219.1\|WP_058080469.1\|2855651_2856281_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.06739e-10
NZ_CP013219.1\|WP_058080470.1\|2857788_2858709_-\|NAD(P)H-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.80004e-64
NZ_CP013219.1\|WP_058080476.1\|2863653_2865291_+\|twin-arginine-translocation-signal-domain-containing-protein	gnl\|CDD\|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	1.94381e-103
NZ_CP013219.1\|WP_058080477.1\|2865295_2866252_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.12509e-102

>NZ_CP013219.1|WP_058080469.1|2855651_2856281_+|TetR/AcrR-family-transcriptional-regulator
MVSQERAERTRGRLLEAAAREFSLQGYSGTSLQRVSRSAGVTMGALTFHFPTKPALAEAVHAQGSEITREAVARTGAEPAEERDYPLLQRVIRIAHAVAALLCEEPTVRAAGRLTRERVPGPADWTDSWLPDVRGLLDQASREKELRTGVDPEIVALLLRYLVLGVLDSPQPTEDCASHLSQLNAVWAVLLTGLIGTAVDTAQAEDAAG
>NZ_CP013219.1|WP_014672603.1|2854391_2855315_-|helix-turn-helix-domain-containing-protein
MIRRKRREAVPAPRRDAVQAPAAAKPADLRFAELGSFLAARRAEVTPEQVGLPGGGSRRLSGLRREEVAMLAGIGASWYAWIEQGRAKNVSPEILAAIAGVLRLDEAQCLYVMRLAGYTAPRRPRAGVEDDDLLGAEIVDGFLPGPAYFLDRYWDITAANTAAERLLGVEGGHANYLEMLFLDQGARSRFPLWERDAADAVARFRTQSGEFLGDPRLASLVGRLRERSPFFADLWDQHRISDGSGITQVVRHPGLGQVSLDQVCLDLSCRPGRQLILLRPHSGGDAERIGNWIREVSPAYTVSTVPA
>NZ_CP013219.1|WP_058080468.1|2853910_2854333_+|MarR-family-transcriptional-regulator
MAHSNTPGRLADGDVCSLVNALSQAIERHTRQVSDRFGLTSAQAVALRELPEPRTLRELARRMHCEASNATFVADRLEAMGLLERRPHPTDRRAKLLHLTPEGAALRKKVVRQLQVDSPIGRLTDEEQTTLRDLLARAAD
>NZ_CP013219.1|WP_058080467.1|2852219_2853665_-|MFS-transporter
MTSSGSARHKGLILAALALAQLIIALDYSIVFVALPDIGSGVGFSDQQLQWVIGAYAVAFGGFLLLGGRMSDLLGRRRMFLTGLALYALASVLGGLASDPWVLVAARAVQGVGGAFLAPATLSLLTSNFEEGPERNRALGVWGATGSSGMVVGSLLGGVLTQAFGWAAVFFVNVPLALGVALLGLRAIPADRPTERRQGFDLPGGITVTGGALLLVFGLVQGPEIGWAAPVTLVSFVAAAALIVGFVVIESRTADPLVPLRVFSFRSLRLGSMITFAFMATFGASAYFITLALQTVRGWSALATGLAFILPCACILVGTVIGGRMSTAIGVRSTLVIGLLVGAVGTAVFAAFLGNGSTYAQMVPGIVIFSIAQGVIWTAMFSAATTGVEEKLQGLASGLATSGQQVGAAVGLAVLVAVSNAVSGSDPAPAELSDGLQAATFTSAVLILLTVGLALALPKPAAAVTETPVPAETPVRANEAV
>NZ_CP013219.1|WP_058080466.1|2851286_2852141_-|MBL-fold-metallo-hydrolase
MPLPTGHNSSPTALSSLRLGGHTVTVVPDGAVQLHPRRWLPDSTDRDWTGDHAGLLDDQGYLGTSVASLLVEHDGRALLLDAGFGPHDIPAEDTIDTIGALRGGRLPDALARAGRAPADIEAVAFTHLHDDHIGWAFRPGPDRPSPFARATLLASADEWADWPAPPKTAGPPVTPGQEIFPGVTAWPAPGHTRGHTAYVISAGGRRVIAFGDVFHSPAQLARPDWRVSMDALPGQAVRTRREMLAELTRPDTLAFANHFAQGQLGRVVHGGGGTRWQPLSEETA
>NZ_CP013219.1|WP_058080465.1|2850055_2850853_-|HAD-IB-family-hydrolase
MNRTRVAFFDVDGTLTTSGSMFRLLAFYLAAMGHPPRVYEERRRELKAMAAIGCPREATNRAYFRGLQGVDAAVLAGVAGAWFAAELSTGGYYHEPALAALRRHQERGDHVVLVSGSFPAPLRPIAADLGVEEVWCTEPEIVHGRHTGDLKGPPMIGAAKAEAVRTVLARRGATPDDCVAYGDHVSDLPMFKAVGSAVVVGGDERLRTSARAHGWPLLPGTLPPPALPLPRTGPGAAARTRPAFHSPHSSFAPTSPTRYEMPETA
>NZ_CP013219.1|WP_058080464.1|2848712_2850059_-|acyl--CoA-ligase
MTAWFFERMHSFGDADAIVFDGRSHSYAQLLELTDRWKTFLDARQVRPGQVVALEGASSVEACAGLLALIDRGAVVVPLTPLPPAKRSEFLDIAEVEAVITVDALGGRHRFEATGRTAGHDLYGRLRAARTPGLVLFSSGTTGRSKATVLDFAKVLGKYGEARKPKRTLGFLNLDHIGGINTLLHTLSQGGALVTIDDRTPDTVCAAIAAHRIQVLPTTPTFLNMLLISRAYTRHDLSTLQLITYGTEPMPLGVLQRLDTTLPGVRLKQTYGLSELGILSTRSRDNDSLWVKLGGEGFDYRIRDGILWIRSDMAMLGYLNAPAPFDEEGYFNTQDAVETDGDYVRILGRKSEIINVAGEKVYPSEVENVLLEMDIIADATVSGRHSHITGQVVQARVKLTEPADPREVARRVRTYCARRLEAYKVPLLVEVTDDDQHSDRFKKIRSAA
>NZ_CP013219.1|WP_058080463.1|2847936_2848716_-|SDR-family-oxidoreductase
MNPAAHPAGPAPDGPGAPGAPVAVVSGGSRGLGRVLVERLLADGRRVATFSRRPNEFTEAMAGKHPDSFHWAAADLTDFAGLREFARDSARRFGRIDLLVNNAGVLHQELFLTGAPARMNDLVGANLLAPMHLAQACARVMTRTGGGTIVNVSSINAIRGYRGVAVYAAAKAGLEGLGRALARELGPLGIRVNTVTPGFFDSDMTADVTSRNREKIQHRTPLGRLGTVDEIAEAVLFLASPEARFITGHTLVIDGGITC
>NZ_CP013219.1|WP_014672596.1|2847661_2847943_-|hypothetical-protein
MLNTTRTSDIRAAVQREIDSVLLDEEGGTGYSLDDPLLTAGLNSLLLAQLLLQLEAELGVDPFGEDRSITDVRTVGELIDVYEEAIRAASAEV
>NZ_CP013219.1|WP_058080462.1|2846627_2847659_-|hypothetical-protein
MGTGRQLSLTSIDDYLGPSETRFFSRGYQRAGYRVRDVVVTPADAPDAGVRATVDVTYPADWSRKKDGTDLRPHLSTVDALVLGVQLAELHLAHGYGLDGAARTRMRLRKVVLRAGGAPQEELTDIPLAARLVRTEELPGSARHLSVHDCTVGNLRVRCEIEHDIATRTVEEARHESLEKALGPGTERFWGEGFKNRRHFIHDVRVDLDALAARADVHFAPEPDAGREGIEGGTQPSVSLIDAFVVNLQLVQVLMYELDSISRAESNTLWMMQTVLEAPRDGSPAPGGPDAPAVAEAALTGKRLLPLRGGIWRSVEIKAGLAGVRLRCGFAHELPAQAAATAA
>NZ_CP013219.1|WP_014672605.1|2856960_2857713_-|SDR-family-oxidoreductase
MFTGKTVMITGASSGIGAATARHLAAQGAAVVLMARREEKLEKLAAEIGAEGGRALPCPGDVTSAEDVRRVVDTAVSSFGSLDAAFNNAGWGTAGVRLHELTDDVYDQIMDVNVRGGWNCMRYQIPAMLAHQGGTILNTSSTAGQFATGAAAPYVAAKHALIGLTRAAAAEYGDQGIRINALVVGTTRTELMEAVIERHPEVETQGVSRAIQRRMADPLEIARAAAWLLSEQSSFVTGAAVPVDGGCSAV
>NZ_CP013219.1|WP_058080470.1|2857788_2858709_-|NAD(P)H-binding-protein
MTAPGAPAPARTGGPATGTAGPGIVITGATGAVGRHVARLLAQRAGARHSLFVRDPGKAAALGLPGPAVRGDYTDPESLRRALDGADAVFVVTANPLRSQDDERVLAAARAGGVRHAVKLSWCGVADPGADDLVARWNRRSEELLRDSGLSWTVLRIRTPMSNALAWAPSIRDRGVVRAFGGAARTACVDPRDVAAAAVAALTDPRHAGRTYALAGPEALSPREQTGVLAEVLGRPLVFEEVAEEEARAGWSRRYGERVAEALVSGARRRAGGAAAACDDGTLARLLGGRPRTFGEWATDHVREFV
>NZ_CP013219.1|WP_058080471.1|2858705_2859302_-|TetR/AcrR-family-transcriptional-regulator
MRTRALVARAAAEVFAECGFAGASVTKITQRAGLTLGAMYFHFENKEALAREIVRSQPDRVTPPHESRGLQHAIDITLTWAHQLLDDPFLLAGARLVMEQDLFIGPEENSHQQWTEVMAQDLALARKEREVRANVDVNAVARLVVNACTGAQMHAHLESGRRDLPQRVTEMWNVLLPTIATPSALNRMRLDESRGKSA
>NZ_CP013219.1|WP_058080472.1|2859478_2860492_+|gamma-butyrolactone-biosynthesis-enzyme
MATPTRQRSVSSRSSATDVKQYAGKVDLTEVLVTDWHPVTDRTHAVTVEWPAHHPFYTTTPQRHGLLFFIESVRQALSVASHLGLGVPRGYRMGWERLTCTASPEALATGPDPSVVQLTITHDDVVRRKSGVCRLTARVQATRNGLPLGTAQIGYTAYPPALYDRLRGARADAQAAFARALPPGPAVAPALVGRTDARDVTLAPDTSAGPDTAAGPGGTPRRWALRSDTGHRVLFDHPHDHIPGMVLLEAVIQAAHADAAPRPVVPVELDTVFHRYVEFDLPCAIVTEDTGTDEPGRQRRRISGVQDGQTAFTTLITGIVPDPAPLPRARRAGTAAG
>NZ_CP013219.1|WP_058080473.1|2860740_2861445_+|AAA-family-ATPase
MNLSISGTYSVGKTLTSMALAHLTGIPRTSAPTMRELLPISLPGKTLEECNGAELIMLITRRIQGRAVAESHLPNGFISDGSALHEWSYATVRVKVGINPNESVDLDNVEMTDEVRFYAEVMKQIAIPAKQHTKQSYDAFVHLPIEFPIVEDGHRPVNERFRQLAEELLLKTLEELEIPVHVVGGTIPERLARIVDIFGFTPVMSIEEAIDRAEDEYSKIDTRNELERLADVAA
>NZ_CP013219.1|WP_058080474.1|2861536_2862136_+|ATP-binding-protein
MRIAFVGAYGNGKTTLTTELSERLGLERVHGSAMRDPAGGTPKALEETNEPELIQLAVRRFTERAVDEARLQDGFLSDGSALHEWVYSKVRLAVGRYPEPSVTLADVHASTSPYEEVVDQLALLGKEHATANYDVVIHCPVEFPLPEGVDPISERFRTLSDELMLEIVKTLDVPLHIVTGTLEERIEQVLKIAGLPQTA
>NZ_CP013219.1|WP_058080475.1|2862254_2863409_+|LLM-class-flavin-dependent-oxidoreductase
MHSGIGVFLSPLHAPGQDPHLTIRRDLQLVEHLDELNYDECWFGEHHSLAWPTIGAPETIIAAAAERTRQIKLANGVVPLPFHHPYNVATRALMLDHLTRGRYILGVGPGATPNDSHQFGVAQDDLKRMASEAIPVVRELVNGEERVSAKTDWFVLQDAKMQLPRYSKPGIEMAISSIGTPNSPKVAGQFGLSLVSWGAPPPGLPAVDLAQQWRYAEESAEEHGNTMDRADWRVVVPLYIAETREQAYQDVRQGFSEWLWGYWGKAAGFDVAAGMEGVKSSQELEAGVEQGLAIVGSPEDAVAAIERLQEQTGGFGRFLVYAMNWASFEKTKQSYALLAEQVAPRFSGSTARGDESIQWSIDNRHVFPHTEARRAREAREARTV
>NZ_CP013219.1|WP_058080476.1|2863653_2865291_+|twin-arginine-translocation-signal-domain-containing-protein
MRDDDVNPGVPAPPRRQFLKYSGALGATAALSPALAACSAGPESTNDTGGGGSGKDRTLTAVIGYGNDGSWDPTQTASAFAMAANNHIYEGLLDTDPITREPYPALATAIPADPSATTWRFPLRSGATFHDGKPVTADDVVFVFDRILDPDTQTLAKGFFAPWLDSVRKVDARTVELVLKFPFPDGLSRLTLAKIMPRHVFSRPGAWDDAIKGLAVGSGPYRQTAHHPKSNTTFEAFAAYNGPRKPAFRKMNWLTIVDAAPRVAKISGTGAGAQIADNIPYANIPRLEQGGLKVAGGAGMNNLFLMFNTRHEPFDDVRVRQALHYAIDTEKMVRVALKGHGRPASSFLNEDNPGYRRARTVYDHDPDKAKALLRAAGVTGLKVEILAVNVSWIVDCLPTIKSSWDAIGVRTTLAPQETTAVFTKMDQKQDYQVVAAASNPNQFGRDADLIMHYNYGPGNLWMRYTRWAGHPVAQRLFKDMDRAAREPDPAKKKAMIQDYIDVVAEQAVLYPVVHNELMTAWDPRELSGIRAQPYPGINVLQAKWT
>NZ_CP013219.1|WP_058080477.1|2865295_2866252_+|ABC-transporter-permease
MTAVVRILLRRVALLVPLLLGIVLFVFLVMRFSHVDPASAFFQGANPTPGQLHDFRERNGLLDPLPLRYVHFVGDLLHGDLGTSALIRAPVVDQVTTALPLTLQLTFLGLALAVVLALAGGVTAAVYRDRLPDQLIRVVSLVGVAAPGFWLALLMIQYLAVDRGWFPTGGYVNPADSLTGWLRTMALPAFALSLPVAAQLTRIVRTSVVEELDKDYVRTAIGSGLPPRVVVGRNVLRNALVNPLTVLGLRVGYLLGGAVVIETIFSLPGMGKLMIDAVQNGDPAVVQGVVLTTATGFVVVNLLIDILYLLVNPRLRAA
>NZ_CP013219.1|WP_058080478.1|2866251_2868249_+|dipeptide/oligopeptide/nickel-ABC-transporter-permease/ATP-binding-protein
MVTRANLGKRLSRPGGVRLRGWRRLPPLSRTAVSFLAVVIVVAVLAPVLAPHDPLDQQDPVGGTGAPSAAHWLGQDSLGRDVLSRLMYGARWSLAIGLGATALALAVGALVGALAATSRKAVDETLMRCLDVVMAFPGIALAAVLVAVFGGGIGVLICAIAFLFTPPVARVVRANVLDQYGEDYVTAERVIGARTPHIVLRHVAVNCAAPVLVFCTVQVAEAIVFEASLSFIGAGVRPPDPSWGSVIADGKNMVLTGGWWATVFPGLLILLTVLALNILSEGVSDAWAAPAPREVEAPAQGARPADRPKTPEPGTGEVLPLPGLTQAARRLRSRARPLPDRSGQPVLAVERLAIGFPDRHRGVDIVAGVGFAVYPGEVLGLVGESGCGKSLTALTLMGLQPKGARVGGRVRFGQRDLLAEPTRVRRRLLGHEMAMVYQDALSSLNPAMTVRAQLKQLVRRGGRRGPRELMELVGLDPDRTLRSYPHELSGGQRQRVLIAMALSRDPRLIVADEPTTALDVTVQAQVMELLLRLRAELGFALILVSHDLALVADITDRVAVMYGGQIVETGVTADVVAAPAHHYTRGLLGSVLSLESAEERMTQIKGVVPAPADFPAGCRFADRCPLATEVCHTTAPVLAGTPAHTAACHHPAVELASAQSEEALQ

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Crispr_ID: NZ_CP013219_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013219_6

2974438-2974618

Orphan

Consensus_repeat	Method
CGGCCGGCTGCGGGGCGCT	CRT

3 spacers

The CRISPR arrays of NZ_CP013219_6

>merge|NZ_CP013219|6|2974438-2974618|CRT
CGGCCGGCTGCGGGGCGCTCCGCGCGGTACGGGCGGGGCGGGTGGCTTGCCTCGCCGGCCGGCTGCGGGGCGCTTGGGCACGGTGCGGGAGGGCTTGCCTCGCCGGTGCCCGCTGCGGGGCGCTCGGGGGGCGGGGCGGCTTGTCTCGCCGGCCGGCGGGGGCGCTCGGACGCGGGGCGGG

>NZ_CP013219|6|1|2974438-2974618|CRT
CGGCCGGCTGCGGGGCGCT	CCGCGCGGTACGGGCGGGGCGGGTGGCTTGCCTCGC
CGGCCGGCTGCGGGGCGCT	TGGGCACGGTGCGGGAGGGCTTGCCTCGCCG
GTGCCCGCTGCGGGGCGCT	CGGGGGGCGGGGCGGCTTGTCTCGCCGGCCGGCGGGGG
CGCTCGGACGCGGGGCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013219.1\|WP_058080518.1\|2966492_2968745_-\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NZ_CP013219.1\|WP_058080520.1\|2972446_2972809_-\|DUF4233-domain-containing-protein	unknown	unknown	gnl\|CDD\|379420
NZ_CP013219.1\|WP_058080516.1\|2963747_2965250_-\|CYTH-and-CHAD-domain-containing-protein	unknown	unknown	gnl\|CDD\|214880
NZ_CP013219.1\|WP_058080521.1\|2974781_2977406_-\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235582
NZ_CP013219.1\|WP_014672704.1\|2969582_2970521_-\|rod-shape-determining-protein-MreC	unknown	unknown	gnl\|CDD\|237560
NZ_CP013219.1\|WP_014672713.1\|2980032_2980698_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|237133
NZ_CP013219.1\|WP_041665168.1\|2983754_2983949_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_014672714.1\|2980765_2981383_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
NZ_CP013219.1\|WP_014672715.1\|2981655_2983044_-\|trigger-factor	unknown	unknown	gnl\|CDD\|234956
NZ_CP013219.1\|WP_014672706.1\|2971967_2972381_-\|nucleoside-diphosphate-kinase	unknown	unknown	gnl\|CDD\|179085
NZ_CP013219.1\|WP_014672708.1\|2972816_2974331_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	unknown	unknown	gnl\|CDD\|223362
NZ_CP013219.1\|WP_058080515.1\|2961715_2963677_-\|TIGR03960-family-B12-binding-radical-SAM-protein	unknown	unknown	gnl\|CDD\|188475
NZ_CP013219.1\|WP_058080523.1\|2985594_2986041_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|213552
NZ_CP013219.1\|WP_058080519.1\|2968891_2969569_-\|rod-shape-determining-protein-MreD	unknown	unknown	gnl\|CDD\|274574
NZ_CP013219.1\|WP_014672712.1\|2978574_2979861_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	unknown	unknown	gnl\|CDD\|235422
NZ_CP013219.1\|WP_041665170.1\|2986107_2987280_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP013219.1\|WP_014672705.1\|2970686_2971706_-\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|237562
NZ_CP013219.1\|WP_058080517.1\|2965299_2966496_-\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NZ_CP013219.1\|WP_014672717.1\|2984462_2985566_+\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|226122
NZ_CP013219.1\|WP_058080522.1\|2977542_2978502_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236669

Protein	Function_ID	Function_description	E-value
NZ_CP013219.1\|WP_058080518.1\|2966492_2968745_-\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP013219.1\|WP_058080520.1\|2972446_2972809_-\|DUF4233-domain-containing-protein	gnl\|CDD\|379420	pfam14017, DUF4233, Protein of unknown function (DUF4233). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 147 amino acids in length. Proteins in this family are integral membrane proteins.	2.00212e-24
NZ_CP013219.1\|WP_058080516.1\|2963747_2965250_-\|CYTH-and-CHAD-domain-containing-protein	gnl\|CDD\|214880	smart00880, CHAD, The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family. It has conserved histidines that may chelate metals.	1.39167e-39
NZ_CP013219.1\|WP_058080521.1\|2974781_2977406_-\|valine--tRNA-ligase	gnl\|CDD\|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0
NZ_CP013219.1\|WP_014672704.1\|2969582_2970521_-\|rod-shape-determining-protein-MreC	gnl\|CDD\|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	3.00044e-66
NZ_CP013219.1\|WP_014672713.1\|2980032_2980698_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|237133	PRK12553, PRK12553, ATP-dependent Clp protease proteolytic subunit; Reviewed.	2.02908e-121
NZ_CP013219.1\|WP_014672714.1\|2980765_2981383_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.6791e-115
NZ_CP013219.1\|WP_014672715.1\|2981655_2983044_-\|trigger-factor	gnl\|CDD\|234956	PRK01490, tig, trigger factor; Provisional.	1.61798e-153
NZ_CP013219.1\|WP_014672706.1\|2971967_2972381_-\|nucleoside-diphosphate-kinase	gnl\|CDD\|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	1.47618e-78
NZ_CP013219.1\|WP_014672708.1\|2972816_2974331_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	gnl\|CDD\|223362	COG0285, FolC, Folylpolyglutamate synthase [Coenzyme metabolism].	3.04605e-139
NZ_CP013219.1\|WP_058080515.1\|2961715_2963677_-\|TIGR03960-family-B12-binding-radical-SAM-protein	gnl\|CDD\|188475	TIGR03960, radical_SAM_domain_protein, radical SAM family uncharacterized protein. This model describes a radical SAM protein, or protein region, regularly found paired with or fused to a region described by TIGR03936. PSI-BLAST analysis of TIGR03936 suggests a relationship to the tRNA pseudouridine synthase TruA, suggesting that this system may act in RNA modification. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP013219.1\|WP_058080523.1\|2985594_2986041_-\|HD-domain-containing-protein	gnl\|CDD\|213552	TIGR00691, PppGpp_synthetase., (p)ppGpp synthetase, RelA/SpoT family. The functions of E. coli RelA and SpoT differ somewhat. RelA (EC 2.7.6.5) produces pppGpp (or ppGpp) from ATP and GTP (or GDP). SpoT (EC 3.1.7.2) degrades ppGpp, but may also act as a secondary ppGpp synthetase. The two proteins are strongly similar. In many species, a single homolog to SpoT and RelA appears reponsible for both ppGpp synthesis and ppGpp degradation. (p)ppGpp is a regulatory metabolite of the stringent response, but appears also to be involved in antibiotic biosynthesis in some species. [Cellular processes, Adaptations to atypical conditions].	3.48795e-14
NZ_CP013219.1\|WP_058080519.1\|2968891_2969569_-\|rod-shape-determining-protein-MreD	gnl\|CDD\|274574	TIGR03426, shape_MreD, rod shape-determining protein MreD. Members of this protein family are the MreD protein of bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. It is highly hydrophobic (therefore somewhat low-complexity) and highly divergent, and therefore sometimes tricky to discover by homology, but this model finds most examples. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	2.70413e-14
NZ_CP013219.1\|WP_014672712.1\|2978574_2979861_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	gnl\|CDD\|235422	PRK05342, clpX, ATP-dependent Clp protease ATP-binding subunit ClpX.	0
NZ_CP013219.1\|WP_041665170.1\|2986107_2987280_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.43741e-35
NZ_CP013219.1\|WP_014672705.1\|2970686_2971706_-\|rod-shape-determining-protein	gnl\|CDD\|237562	PRK13927, PRK13927, rod shape-determining protein MreB; Provisional.	0
NZ_CP013219.1\|WP_058080517.1\|2965299_2966496_-\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	6.43295e-123
NZ_CP013219.1\|WP_014672717.1\|2984462_2985566_+\|acyltransferase-family-protein	gnl\|CDD\|226122	COG3594, NolL, Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism].	2.59194e-28
NZ_CP013219.1\|WP_058080522.1\|2977542_2978502_+\|hypothetical-protein	gnl\|CDD\|236669	PRK10263, PRK10263, DNA translocase FtsK; Provisional.	2.74752e-07

>NZ_CP013219.1|WP_014672708.1|2972816_2974331_-|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase
MSEAPGTSDTPDPLDSFDEIIEAETTRDPDLAVIEAGSRTLRTQGGPAQADVPARPEDPEVDKALREVEAELATRWGETKLEPSVSRIAALMDVLGEPQRSYPSIHITGTNGKTSTARMIEALLGAFELRTGRYTSPHVQSITERISLDGAPITAERFIETYQDIKPYVEMVDGQQEYRLSFFEVLTGMAYAAFADAPVDVAVVEVGMGGSWDATNVIDGDVAVVTPIDLDHTDRLGETHAQIAGEKSGIIKQDATVILAQQPVDAAQVLLKKAVEVDATVAREGLEFGVVDRQVAVGGQLLTLRGLGGEYHEVYLPLHGAHQAHNAAVALAAVEAFFGVGAQRAEPLDIDTVRKAFAAVSSPGRLEVVRRSPTVVLDAAHNPAGAEATAEAVREAFDFTRLIGVVGASGDKNVRGLLEAFEPIFAEVVVTQNSSPRAMDADELAAIAVEVFGDERVQVEPRLPDALEAAITLAEEEGEFAGGGVLVTGSVITVGEARLLLGKG
>NZ_CP013219.1|WP_058080520.1|2972446_2972809_-|DUF4233-domain-containing-protein
MRTLCASTLIGEFFVIGFAGLVAMKDPGLSTSTVWLVSGIAMLLCVLLCGMVTRPGGVALGWALQIALIASGVVVPTMYFLGAVFAALWWASVHFGRKVDEAKARFAAQAQSSSSTPDAA
>NZ_CP013219.1|WP_014672706.1|2971967_2972381_-|nucleoside-diphosphate-kinase
MSQRTLVLLKPDAVRRGLTGEIISRIERKAGWQITALELRTLDQDTLEQHYGEHKGKPFYEPLVEFMSSGPVVALIVEGERVIEGVRQLAGPTDPIAAAPGSIRGDYGVIVRENLIHASDSEESAEREVKIFFPGRA
>NZ_CP013219.1|WP_014672705.1|2970686_2971706_-|rod-shape-determining-protein
MSFIGRDMAVDLGTANTLVYVRGRGIVLNEPSVVAINTNTGGILAVGAEAKKMIGRTPGNIVAVRPLKDGVIADFEITERMLRYFILKIHKRRYLARPRVVVCVPSGITGVERRAVIEASSQAGARQVHIIEEPMAAAIGSGLPVHEATGNMVVDIGGGTTEVAVISLGGIVTAQSIRVAGDELDNAIIQYIKKEYSLLLGERTAEQIKITIGSAYDLDTDEHTEVRGRDLVSGLPKTVVISAAEVRKAIEEPVNAIVDAVKTTLDKCPPELSGDIMDRGIVLTGGGALLRGLDERLRRETGMPIHIAEDPLDSVALGSGKCVEEFEALQQVLDAQPRR
>NZ_CP013219.1|WP_014672704.1|2969582_2970521_-|rod-shape-determining-protein-MreC
MRDTKESRLLLVLLVAIAFALITVDIRGGRNSPVDGARHAAAAVFGPVENGLSSAVNPVGDAVSAVRASGSRHDRLAALEKENAALKAKLGSDDRNRSRLKQLDKLLKVAGEGQYGIKGAQVIAIGSAQGFSWTITIDAGADDGIKRDMTVLNGDGLVGRVTTVGPSTSTVLLANDPDFTVGTRMEAGDELGFASGQGDRPLRVELLNGKAEVKKGDRLVTFGSQADKPFVPGVPVGVVSRVDPSGGGLTRTLYVTPYVSFTKLDIVGVVVAPPKQDPRDTVLPAKPKPVPTPTVTVTVTPSADAPATDEQQ
>NZ_CP013219.1|WP_058080519.1|2968891_2969569_-|rod-shape-determining-protein-MreD
MRVNRILLATPLVVVALVIQVSVLARLHLPGAVPDLLLLTVLGLAMVYGHVGGALVGFGAGLLADLAPPADHAAGRYALVLCVIGYLAGLVKPENGRLKSASGPMAVVVAAAIGSTLLYAGVGALVGDTAARHVGLPGLLFSAALYDLLLAPFVVPGVMWLARRADNDPLTETGPAAKAGDISSGWLSSGTGLRIGSQRSGLGALKAKARTRSARVGRIKGVKRL
>NZ_CP013219.1|WP_058080518.1|2966492_2968745_-|penicillin-binding-protein-2
MTNIPETGRTPRVQIRLVVIQILVLSLLGTLGGRLWYLQIREGAEYQKEASGNHVQQVVDPAVRGDILDARGVPLADNETRLVVSASRTDLLKQKDDGKAVLTKLAGVLGMSPAEVMQKVRLCDAKTPQPCWNGSPYQPIPITDEATAKQALQIRERSEDFPGITAEPEAVRRYPGPGKSNTAQVLGYLSPVTDAEIQQAKDSDSPYLRSDMVGRSGLERTYDKVLRGKAGVTRYEVDNLGRVIGKAKSDAAESGSNLVTSIDSRVQRVAEYELDKAMKAARQQFDKITGTNYKADSGAVVVMEAKTGRIVAMASAPTYDPNVWVGGISAKDYKALTGKDSDYPLLNRAIQGQAAPGSTFKVVSTAAAVEAGYDFDGRYPCTSSYSVGGQVFKNFEGENFGPIPLGRALEVSCDTVFYYLADKEWKKDGGINPKKGQPKDYFYKAAHQFGLGKETGVDLPNEVTGRVPDRQWKQAYWKANKDAWCKTGKKDGSYVEKIAYENCLEGNKMREGDSINYSIGQGDTLVTPIQEAVIYGAVANGGTMYQPTIGKAIISADGRTVREIKPTKRGRLPVSQATLKGMDDAFAGVITRGTAAWKFGGWPQDKIPLHAKTGTAEVYGKQTTSWLATYSKDYTVIMTIAQAGTGSGASGEAVRNIYSALYGVQGDGSIDSKKALLPEPQKGLPKVRTDGTIAAPKVTGDPAKDAETAQKNNPTNGDGQQPAGTTPSPGTGNRDTRRRPRRRGSRRMPS
>NZ_CP013219.1|WP_058080517.1|2965299_2966496_-|rod-shape-determining-protein-RodA
MTGANSFSVSGYGPERAGWTRIFARDSLTRRLDWPILLAATALSLLGSLLVYSATRNRTELNQGDPYFFLLRHLMNLGIGIALMIGTVWLGHRALRNAVPILYGLSVLLALVVLTPLGATINGQRNWLVIGGFSLQPAEFLKVSIILGMAMMLAARVDAGDKPYPDHRTVFQSLCLATVPILILLLMPDLGSVLAMVAIILGVLLASGASNRWVFGLLTAGVIGCVAIWQLHILDEYQINRFAAFANPDLDPAGVGYNTNQARIAIGSGGLTGAGLFHGSQTTGQFVPEQQTDFVFTVAGEELGFLGAGFIIFLLGVLLWRACRIARDSTELYGTIVAAGIVAWFAFQSFENIGMTLGIMPVTGLPLPFVSYGGSSMFAVWVAVGLLQSIKVQRPMSA
>NZ_CP013219.1|WP_058080516.1|2963747_2965250_-|CYTH-and-CHAD-domain-containing-protein
MADAKREIERKYESDDGGLPDLTGVGAVAAVLDKGLMELDATYYDTVDERLAAAALTLRRRTGGADAGWHLKFPVAPGVRDEIQAPLCDTVPEEIAALVRSRVRDAALVPLVRLRSARDVRHLVDADGALLAEASVDAVTAERLSGGSGVAQWTEIEVELADGGDPALLDQLEKRLGKAGVRPSRSPSKLARALEETAGGRRRKQAGPPPPVTAGDHVLAYLRAQRDAVVELDPAVRRDLPDAVHRMRVATRRARSTLRTFGALLDRTVTDPVGAELKWLAGELGVDRDQEVLADRLTTALDALPATLVTGPVPERLSAWSRARRGGAHAHLTGVLDSRRYLALLDALDALLADPPLRRAAGKKPGKALAKAVHKDQKKLTDVLEHALALPPGQDRDLALHEARKKAKRTRYAAEAATEALGAPARALTKAMKSLTTVLGDHQDSVMARRTLRELAAVAHAAGESAFTYGVLYGREEARAAAEEAELPRLWQEIRSGAVR
>NZ_CP013219.1|WP_058080515.1|2961715_2963677_-|TIGR03960-family-B12-binding-radical-SAM-protein
MPVESVFPQLEALLPHVQKPIQYVGGELNSTVKPWDECDVRWALMYPDAYEVGLPNQGVMILYEVLNEQEGVLAERTYSVWPDLEELMRKHGVPQFTVDSHRPVKAFDVFGLSFSTELGYTNMLAALDLAGIPLESGDRTIDDPIVLAGGHAAFNPEPIADFIDAAVIGDGEQAVLDMTRIIREWKAEGRPGGREEVLFRLARTGGVYVPAFYDVEYLPDGRIARVVPNKSGVPWRVSKHTVMDLDEWPYPKQPLVPLAETVHERMSVEIFRGCTRGCRFCQAGMITRPVRERSITGIGEMVDKGLKATGFEEVGLLSLSSADHSEIGDVAKGLADRYEDDKIGLSLPSTRVDAFNIDLANELTRNGRRSGLTFAPEGGSERIRKVINKMVSEEDLIRTVATAYGNGWRQVKLYFMCGLPTETDDDVLQIADMATRVIQKGREVSGSNDIRCTVSIGGFVPKPHTPFQWAPQLSAEETDERLAKLRDKIRGDKKYGRSIGFRYHDGKPGIVEGLLSRGDRRIGAVIRAVYDDGGRFDGWREHFSYDRWMRCADKALAPFGVDVDWYTTRERGYEEVLPWDHLDSGLDKDWLWEDWQDALDETEVEDCRWTPCFDCGVCPQMDTHIQIGPTGKKLLPLTVKNAGPTPAASGHTH
>NZ_CP013219.1|WP_058080521.1|2974781_2977406_-|valine--tRNA-ligase
MTENASQQPPAPDTELPTQYAPADVEGPLYERWVERGYFEADAKSDKPPYTVVIPPPNVTGSLHLGHAFEHTLIDALTRRKRMQGYETLWQPGMDHAGIATQNVVERELGKEGKSRQDLGREAFVERVWQWKAESGGQISGQMRRLGDGVAWSRERFTMDEGLSQAVQTIFKKLYDDELIYRAERIINWCPRCLTAISDIEVEYQDDDGELVSMRYGDGDDSIVVATTRAETMLGDTAVAVHPDDERYRHLVGKLIRLPLTDRSIPVVADTHVDPEFGTGAVKVTPAHDPNDFEIGQRHDLPTITVMDEHAVITVHGPFQGMDRLEARSAIVAALRAEGRIVAEKRPYVHSVGHCSRCKTTIEPRLSMQWWVKVGPLAKAAGDAVREGKVKIHPQEMEKRYFDWVDNLHDWCISRQLWWGHRIPVWYGPDGEVVCVGPDEEPPTGEGWHQETDVLDTWFSSGLWPFSTLGWPEQTESLAKFYPNSVLVTGYDILFFWVARMMMFGLYAMDGTPPFHTIALHGMVRDQFGKKMSKSFGNAVNPLDWMDEYGSDALRFTLARGANPGVDVPIGEAWVQGSRNFANKIWNATRFALMNGATVEGPLPDASRMSATDRWILSRLNSVVAEVDAYYEDFQFAKLSDALFHFAWDEVFDWYVELSKTVFQAGGEPAEVSKRVLGEVLDVTLKLLHPVVPFVTETLWTTLTGGESIVIADWPADSGFRDAAAEQEISTLQSVITEVRRFRADQGLQPGQRVPARLTLDGTQLAPHEAAIRQLLRLQPEGDAFTATATLPVAGAEVALDLSGTIDVAAERKRLAKDLAAAEKEKAQATAKLGNEAFLAKAPENVVDKIRTRLAKADEDIARITAQLEKLPEA
>NZ_CP013219.1|WP_058080522.1|2977542_2978502_+|hypothetical-protein
MSNNQPGPYGQPPQQPGPYGQQGQPGPYGQPGPYGQPPQAPQPGYGYPQQAPPAQQPGYGYPQQGAPQQPGPYGQQPNPYGQQQPYGMPQAPQPGGGKKKTGLIIGAVAVVAAVAVGAYFLLSGSGSGGAADDGPHKLTTPATVLSEYKKSKGDSGSMTPSDLKDAEKWGVHDPKDVSAAYDAGDPDNPLSKKQINFGGVYGTIDDPEKTVDAMFAYFKSESQKSSGGKDVVLKGEPTAYEPAGLDGAVLKCQQATAPTGAGSGGPKDVTLTICVWGDHSTIGMVMPMDYANLAAGRGSDPAKDAELTAKFRAEVRVKA
>NZ_CP013219.1|WP_014672712.1|2978574_2979861_-|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX
MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAETSEVRWEELPKPREIYEFLEGYVVGQEAAKKALSVAVYNHYKRVQAGENGGASGRDDAIELAKSNILLLGPTGSGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFAGLEKIIEARAGAKGIGFGATILSKRELEAKDVFEDVMPEDLVKFGMIPEFIGRLPVITSVHNLDREALLKILVEPRNALVKQYQRLFELDGVELDFEREALEAIADQAILRQTGARGLRAIMEEVLQGVMYEVPSRKDVARVVITADVVLSNVNPTLIPRDARGRGSGEQKTA
>NZ_CP013219.1|WP_014672713.1|2980032_2980698_-|ATP-dependent-Clp-protease-proteolytic-subunit
MSNFPGAASGMYEGPRPDSRYVIPRFVERTSQGIREYDPYAKLFEERVIFLGVQIDDASANDVMAQLLCLESMDPDRDISIYINSPGGDMTALTAIYDTMQFVKPDIQTVCMGQAASAAAILLAAGTPGKRMALPNSRVLIHQPAGSTGRGQLSDLEIIANEFTRMREQLENMLAKHSNRPIEKVREDIERDKILTAEEALEYGLVDQIISTRKLNNSTVR
>NZ_CP013219.1|WP_014672714.1|2980765_2981383_-|ATP-dependent-Clp-protease-proteolytic-subunit
MTNLMPSAAGEPSIGGGLGDQVYNRLLNERIIFLGQQVDDDIANKITAQLLLLAADPDKDIYLYINSPGGSVTAGMAIYDTMQYIPNDVVTIAMGMAASMGQFLLTGGAAGKRFALPHADIMMHQGSAGLGGTVSDIKIQAEYLMRTKKRMSELTALHSGQTVEAIIRDGDRDRWFTPEEAKEYGLIDEIITHASGVPGGGGTGA
>NZ_CP013219.1|WP_014672715.1|2981655_2983044_-|trigger-factor
MKSAVETLNPTRVRLTVEVPFEELKDSLDAAYKKINQQVTVKGFRKGKIPARVIDQRFGRGAVLEEAVNDALPKFYTEAVNEAELSPLGQPEVDITELKDGETLNFTAEVDVRPALEIPDYSGIEVEVDAVEVTDEDVEKSVEQLRERFASTSPVERAAEDGDVVTIDLEAKVDGEVLEDGIANGVSYTIGSGELLDGIDDAVKGLSAGEEATFTSELKGGSAAGKEAEVTVKVTQVAARELPELDDEFAQLASEFDTLEELKADSRKRLANMKQFDQATQAQERVLEKLLELVEVPVPEKLLEDEINTRKHNLEHHQLAQMGLTLDKYLEIQGKTAEEFETETREAAVKGIKTQFVLDELVKKENLNVNQEELTEHLMRRAASSGMSPDQFAQAVVEGGQVPLLVGEVARGKALAVVVESATVKDTNGEVVDLDDEEETEEAPAEAEATEASDSAEEKTEG
>NZ_CP013219.1|WP_041665168.1|2983754_2983949_-|hypothetical-protein
MAISLSVVLLLAIILVVLIRGGNIKAGPAIVAILFGFFLASTGMAPSINRFLNSIADSIDSIRF
>NZ_CP013219.1|WP_014672717.1|2984462_2985566_+|acyltransferase-family-protein
MPDRPTPTPAQEQSRTARPGRQRDAFFDNAKYLAIVLVALGHSWSAIKTDNRALEGLYNVVYTFHMPAFIVISGYFSRSFDMRPDRLKRLVTGIAVPYLLFQIAYSLFRRYAGQADDPISLVSPYYLTWFLCALFIWRLTTPLWKLVRRPLPLALGIAMVGSVTPGLDDNLDLGRVLQFLPCFVLGLLLKPEHFALIRRPAVRVLSVPVFAAALAVGWWTVPRVDGGWFYRQSSAQDIGAPWWTGPLMTLAMFGCALLLTACFLAWVPGRRTWFTALGAGTLYGYLLHGFVVKGTLYAGGFDLAERYGALGTVAVTVLAAAAVTVLCTKPVQRVFRFAMEPKMEWAFREDAAELARERQKQRETVGV
>NZ_CP013219.1|WP_058080523.1|2985594_2986041_-|HD-domain-containing-protein
MTRLTLAEVEAVARAAHEGQTDKAGLPYAEHLAAVAQGVRARGGDPEQIAAAWLHDSVEDDALSRQWLAAADLTPRTKAIVDALTKRPGEELEAYARRILATPGALLVKEADLAHNADPRRLAALDEPTRTRLAEKYARTRALLGLEA
>NZ_CP013219.1|WP_041665170.1|2986107_2987280_-|serine/threonine-protein-phosphatase
MAAGRQRRAKAETFTARWKMQWHRARVGLRRSAVDYFRGDGSDWIAFAGLLLMVPVLATMTLLDSVWCSPATLVLPIVAGGLLLRPASLLGLYAAAATALIVESVRLGPYTEGPSRVTPGVVLVVAACGFFGLLTAQFRSRVGVPWRRGGTMLFDLRERIRVQSKLPKLPQGWHHEMALRPAGGQSFSGDFVVAARTNGGRTLEAVLTDVSGKGMDAGSRALLLSGAFGGLLGSLPPHAFLPAANGYLLRQDWDEGFATSIHLVLDLDSGDYELYSAGHPPGLQLSAGSGRWEEKAAEGPLLGVYDGAQFDPVKGSLRPGDVLMLFTDGLVETSDRDIVEGIDRLTGEADRYVAGGFQGAAWHLIEAVAKDVNDDRALLLICRQPTANGR

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Crispr_ID: NZ_CP013219_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013219_7

4642018-4642104

TypeI-A

Consensus_repeat	Method
CGGGCATGGCCCCGACTGGGCAGGCG	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP013219_7

>merge|NZ_CP013219|7|4642018-4642104|CRISPRCasFinder
CGGGCATGGCCCCGACTGGGCAGGCGTAGCCACCGCGACCGGACAGGCGCAGCCCTTGGGGCGGGCATGGCCCCGACTGGGCAGGCG

>NZ_CP013219|7|5|4642018-4642104|CRISPRCasFinder
CGGGCATGGCCCCGACTGGGCAGGCG	TAGCCACCGCGACCGGACAGGCGCAGCCCTTGGGG
CGGGCATGGCCCCGACTGGGCAGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013219.1\|WP_058081384.1\|4633096_4634617_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|225443
NZ_CP013219.1\|WP_058081392.1\|4652625_4653405_-\|Clp-protease	unknown	unknown	gnl\|CDD\|223616
NZ_CP013219.1\|WP_058083960.1\|4655639_4656092_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_014674091.1\|4654994_4655510_-\|DUF4232-domain-containing-protein	unknown	unknown	gnl\|CDD\|379419
NZ_CP013219.1\|WP_058081389.1\|4643647_4645261_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|312032
NZ_CP013219.1\|WP_014674045.1\|4632072_4632684_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_079088256.1\|4625569_4627861_-\|DEAD/DEAH-box-helicase	cas3	mkCas0139_cas3_CAS-I	gnl\|CDD\|274800
NZ_CP013219.1\|WP_078611786.1\|4624100_4624301_+\|DUF4244-domain-containing-protein	unknown	unknown	gnl\|CDD\|379429
NZ_CP013219.1\|WP_058081393.1\|4653533_4654676_+\|DUF2786-domain-containing-protein	unknown	unknown	gnl\|CDD\|378525
NZ_CP013219.1\|WP_058081381.1\|4628130_4628472_+\|anti-sigma-factor-antagonist-BldG	unknown	unknown	gnl\|CDD\|132914
NZ_CP013219.1\|WP_058081391.1\|4650878_4652567_-\|bifunctional-3'-5'-exonuclease/DNA-polymerase	unknown	unknown	gnl\|CDD\|237876
NZ_CP013219.1\|WP_058081386.1\|4635468_4638300_+\|type-I-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|236048
NZ_CP013219.1\|WP_079088052.1\|4645819_4646713_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133029
NZ_CP013219.1\|WP_058081388.1\|4642293_4643499_+\|DNA-polymerase-III-subunit-delta'	unknown	unknown	gnl\|CDD\|236134
NZ_CP013219.1\|WP_014674040.1\|4624323_4624662_+\|membrane-protein	unknown	unknown	gnl\|CDD\|377921
NZ_CP013219.1\|WP_058081382.1\|4628654_4629089_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NZ_CP013219.1\|WP_058081390.1\|4647165_4650849_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276938
NZ_CP013219.1\|WP_058081383.1\|4629458_4631861_+\|sodium-translocating-pyrophosphatase	unknown	unknown	gnl\|CDD\|234827
NZ_CP013219.1\|WP_058081387.1\|4638410_4641740_+\|dTMP-kinase	unknown	unknown	gnl\|CDD\|234814
NZ_CP013219.1\|WP_107112883.1\|4656163_4656490_-\|30S-ribosomal-protein-S14	unknown	unknown	gnl\|CDD\|181574

Protein	Function_ID	Function_description	E-value
NZ_CP013219.1\|WP_058081384.1\|4633096_4634617_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|225443	COG2890, HemK, Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis].	5.17829e-18
NZ_CP013219.1\|WP_058081392.1\|4652625_4653405_-\|Clp-protease	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	2.37961e-20
NZ_CP013219.1\|WP_014674091.1\|4654994_4655510_-\|DUF4232-domain-containing-protein	gnl\|CDD\|379419	pfam14016, DUF4232, Protein of unknown function (DUF4232). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.	6.73852e-13
NZ_CP013219.1\|WP_058081389.1\|4643647_4645261_+\|alpha/beta-hydrolase	gnl\|CDD\|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	1.2204e-34
NZ_CP013219.1\|WP_058081390.1\|4647165_4650849_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	2.15319e-42
NZ_CP013219.1\|WP_079088256.1\|4625569_4627861_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|274800	TIGR03817, DECH_helic, helicase/secretion neighborhood putative DEAH-box helicase. A conserved gene neighborhood widely spread in the Actinobacteria contains this uncharacterized DEAH-box family helicase encoded convergently towards an operon of genes for protein homologous to type II secretion and pilus formation proteins. The context suggests that this helicase may play a role in conjugal transfer of DNA.	0
NZ_CP013219.1\|WP_078611786.1\|4624100_4624301_+\|DUF4244-domain-containing-protein	gnl\|CDD\|379429	pfam14029, DUF4244, Protein of unknown function (DUF4244). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 95 amino acids in length. There is a conserved EYA sequence motif.	1.33481e-16
NZ_CP013219.1\|WP_058081393.1\|4653533_4654676_+\|DUF2786-domain-containing-protein	gnl\|CDD\|378525	pfam10979, DUF2786, Protein of unknown function (DUF2786). This family of proteins has no known function.	5.57445e-12
NZ_CP013219.1\|WP_058081381.1\|4628130_4628472_+\|anti-sigma-factor-antagonist-BldG	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	4.47419e-34
NZ_CP013219.1\|WP_058081391.1\|4650878_4652567_-\|bifunctional-3'-5'-exonuclease/DNA-polymerase	gnl\|CDD\|237876	PRK14975, PRK14975, bifunctional 3'-5' exonuclease/DNA polymerase; Provisional.	0
NZ_CP013219.1\|WP_058081386.1\|4635468_4638300_+\|type-I-DNA-topoisomerase	gnl\|CDD\|236048	PRK07561, PRK07561, DNA topoisomerase I subunit omega; Validated.	0
NZ_CP013219.1\|WP_079088052.1\|4645819_4646713_+\|glycosyltransferase	gnl\|CDD\|133029	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.95016e-22
NZ_CP013219.1\|WP_058081388.1\|4642293_4643499_+\|DNA-polymerase-III-subunit-delta'	gnl\|CDD\|236134	PRK07940, PRK07940, DNA polymerase III subunit delta'; Validated.	0
NZ_CP013219.1\|WP_014674040.1\|4624323_4624662_+\|membrane-protein	gnl\|CDD\|377921	pfam07811, TadE, TadE-like protein. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in question is this family has a high proportion of hydrophobic amino acid residues.	0.00303273
NZ_CP013219.1\|WP_058081382.1\|4628654_4629089_+\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	7.55462e-29
NZ_CP013219.1\|WP_058081383.1\|4629458_4631861_+\|sodium-translocating-pyrophosphatase	gnl\|CDD\|234827	PRK00733, hppA, membrane-bound proton-translocating pyrophosphatase; Validated.	0
NZ_CP013219.1\|WP_058081387.1\|4638410_4641740_+\|dTMP-kinase	gnl\|CDD\|234814	PRK00698, tmk, thymidylate kinase; Validated.	3.09654e-81
NZ_CP013219.1\|WP_107112883.1\|4656163_4656490_-\|30S-ribosomal-protein-S14	gnl\|CDD\|181574	PRK08881, rpsN, 30S ribosomal protein S14; Reviewed.	3.44114e-07

>NZ_CP013219.1|WP_058081387.1|4638410_4641740_+|dTMP-kinase
MTRAEQPTAHTTAPDDALVADSRERAVRSLLRRPQLKRLWSAQLVSGVGDTLSLLVLVLLVLQSAIAEGAFGGGYRGVAFAVATVFAARVLAALLFGAVLLGPLTSLTAQEGPLDRRWTMVGADGLRAALMIIAPLWIDWTPDNALAVLLVTAFVTGVAERLWTVCRESAAPALLPAPPPEGATVRPLPDHLDALRRLSLRTTFLAVPLAAAALVVAALLNNLLGTGVAWFDQHQAALGSYVAAGLFAASLSVLTYLELPATRTPRARSPLEGLRRPRTVTGVDKGRTGAIPLLVPACAGVAGAIAAAVSVSVLHAKDLGGGPVLYGLLVLGLTGGVAVGIRTAPALLPSLSRRRLLALAIAVTGIALLAAGLVPDVTTVLLIVTLAGVGAGVAANTGHTLLDQETEDSRRARTTEHLHAMSRVFIALGALIAPLVAALIGPHRLENGKFVFAHGGAAFTFMLVGALLLPVAALVLAKVDDRSGVPLRQDLKDALLGGDDPVTAPAANGFFIALEGGDGAGKSTQAEALAEWIRAKGHEVVLTREPGATPVGKRLRSILLDVSSAGLSHRAEALLYAADRAEHVDTVVRPALERGAVVITDRYIDSSVAYQGAGRDLSPTEIARINRWATNGLVPHLTVLLDVSPETARERFTEAPDRLESEPAEFHARVRAGFLTLAASDPGRYLVVDAGQEPEAVTTVIRHRLDVVLPLSEAEIKAQEEARRKAEEEARRKAEEEAARKAEEERLERERQEQLAKLRAEEEERKRRELEEAQRREAERQAEEARQRAEEARRRAEEERQRLLAEEKARAEEEARRRAEEERRRKQAEEEARRRAEEEARQARLRAEEEARRLEAQRKAEEALLRAEEARRQAAEAAAAADAAARRPSTPLPTAPRVVPDAATVPTPVVSPEEAARGTDTRGTDDETTVLRPVREERAARDTRGAHPDSEVTAELPQPPAVAGPADETAALPQVPAGAADGTAVLPPVSADETAELPRVAPGAADETAVLPPVRDGDPADRVPPGFFREERPAAGPDGSEPRTREMPRIDADGTPRRRPRPDWAEETPLDDLPTLADELLGSYDEGQYGDHGDGGEQGRKGRGRGRRG
>NZ_CP013219.1|WP_058081386.1|4635468_4638300_+|type-I-DNA-topoisomerase
MSPTSETAQGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVPEKYTGEVRRLGVDVDHDFQPIYVINADKKAQVKKLKDLLKDSDELFLATDEDREGEAIAWHLQEVLKPKIPVKRMVFHEITKDAIREAVANPRQLNQKLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFSTGRAGDPSDPSSLVARLQTVDGRRVAQGRDFDSLGQLKSENTLHLDEATARALAAALENTRFSVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQIAQKLYENGYITYMRTDSTTLSDTAISAARAQVTQLYGADYLPPQPRTYAAKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFKLYELIWKRTVASQMKDATGNSVTVKIGGTAADGRDVEFSASGKTITFHGFLKAYVEGADDPNAELDDRERRLPQVAEGDALSAEEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIAAGEAKAVPWLKRFYFGEGTATGGAADAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGNDIVLRVGRYGPYIERGEKDTEQHQRADIPDDLAPDELTVELAEELLAKPSGDFELGTDPATGHAIVAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLDDALKLMSLPRVVGTDADGQEITAQNGRYGPYLKKGTDSRSLQSEDQLFTITLEEAQAIYAQPKQRGRAAAKPPLKELGEDPVSGKPVVVKDGRFGPYVTDGETNATLRSGDSVETITPERGFELLAEKRAKGPAKKTAKKAAAKKTAPAKKTAAKKTAAKKTTAAAKKTTAKKTTAKKATASRATASGAED
>NZ_CP013219.1|WP_058081384.1|4633096_4634617_+|class-I-SAM-dependent-methyltransferase
MTDSGPAPLPTADRPDIAARLRDALLAASFTADGLLDLLGAPAYAALARSETVPALRATRGDTPLETLVRLFLLQQPVPHARVAAVLPVEEAVEAGWLRRVGGDEVAATVDVRPYGGPGGEDWFIVSDLGCAVGGAGGIGQRAEGVVLGVGGASTTLAGITVRTPVAAALDLGTGSGIQALHAAQHATRVTATDLNPRALHITALTLALSGAPAADLREGSLFEPVRDDETFDLIVSNPPFVISPRARLTYRDGGMGGDDLCRSLVQQAGERLNEGGFAQFLANWQHVAGEDWQDRLRSWVPRGCDAWIVQREVQDVTQYAELWLRDAGDHRGDPAEYQARYDAWLDEFEARKVRAVGFGWITLRRTGSAEPVVTVEEWPHPVEQPLGETIRAHFERLDYLREHDDAALLDSRFKLVPEVVQEQVGLPGAEDPEHVVLRQHRGMRRATKVDTVGAGFAGVCDGTLSAGRILDAIAQLVGEDPVVLRDRTPAQIRLLVEQGFLEPAG
>NZ_CP013219.1|WP_014674045.1|4632072_4632684_+|hypothetical-protein
MNKKLAAALSGGAVLMVTVSGCSDGGDKGPDPKLVSWAKTVCDAVPAQDAKIRSANASIAAIATDTNLPPKDAQKTYAEAFQDMAEGYKALADALDSAGAPPGIDGGARLQQDAAKNLAGLSTSYADLKKKVDGLNTKDQGKFAKGLKEVALQTKEVGKQSDSGTEALKRLEKGDVKEAMAEQPSCKVTPSGSAQPTASTTAG
>NZ_CP013219.1|WP_058081383.1|4629458_4631861_+|sodium-translocating-pyrophosphatase
MAGLSTPQSDHLTPLAAAVLTDDNRIIVAVIAAVALAALVVAGILVRQVLAAGEGTDSMKKIAEAVQEGAKAYLARQLRTLGVFAVVVFFLLMLLPADDWNQRAGRSVFFLIGAAFSAATGYIGMWLAVRSNVRVAAAAREATPAEGEPEKDLTTVSHTAMKIAFRTGGVVGMFTVGLGLLGASCVVLVYAADAPKVLEGFGLGAALIAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAGMAADLFESYAVTLVAALILGKAAFGDSGLAFPLLVPAIGVITAMIGIFAVAPRRADRSGMSAINRGFFISAVISLALVAIAVFVYLPSKYSALDGVTDAAIKGKDGDPRILALVAVAIGILLAAVIQQLTGYFTETNRRPVRDIGKTSLTGPATVVLSGISVGLESAVYTALLIGLGVYGAFLLGGTSIMLALFAVALAGTGLLTTVGVIVAMDTFGPVSDNAQGIAEMSGDVEGAGAQVLTNLDAVGNTTKAITKGIAIATAVLAASALFGSYRDAITTNVQDVGAKLTGPGSPLSLSLDISQPNNLVGLIAGAAVVFLFSGLAINAVSRSAGSVVFEVRRQFREKPGIMDFSEKPEYGKVVDICTKDALRELATPGLLAVMAPIFIGFTLGVGALGSYLAGAIGAGTLMAVFLANSGGAWDNAKKLVEDGNHGGKGSEAHAATVIGDTVGDPFKDTAGPAINPLLKVMNLVSLLIAPAVIKFSYGDDKNLGVRIGVAVLALLVIVVAVYISKRRGIAVGDDDSAGRVANPPDAAVVS
>NZ_CP013219.1|WP_058081382.1|4628654_4629089_+|ATP-binding-protein
MATVELRFSALPEHVRTARLVAAAVARRAGVDEAVLDEVRLAVGEACSRAVGLHQNSGVTAPVKVALIEEEKQFSIEVGDEAPHAAPGGDTPGAGQEAQAEAEEDEMGLAVISGLVDDVEVTTGRNGGLIRMTWPTAPSAAALA
>NZ_CP013219.1|WP_058081381.1|4628130_4628472_+|anti-sigma-factor-antagonist-BldG
MDLSLSTRTVGDRTVVEVGGEIDVYTAPKLREQLVELVNDGNFHLVVDMEGVDFLDSTGLGVLVGGLKRVRAHEGSLRLVCNQERILKIFRITGLTKVFPIYTTVEEAVAATD
>NZ_CP013219.1|WP_079088256.1|4625569_4627861_-|DEAD/DEAH-box-helicase
MTHTEHLPPRAGRHAVWPDRIRPEVIAAVQACGIEHPWAHQALAAEHALDGDSVVVATGTASGKSLAYLVPVLSTLLDGAEAPNGRGATALYLSPTKALAADQCRSVKELSQPLGTSVRPAVYDGDTPFEEREWIRQYGNYVLTNPDMLHRGILPSHPRWSSFLRSLKYVVIDECHTYRGVFGSHVAQVLRRLRRLCARYGSFPVFLLASATAAEPAVAARRLTGLPVVEVADDASPRGELVFALWEPPLTELHGERGAPVRRTATAETADLLTDLTVQGVRSVAFVRSRRGAELIAVIAQERLAEVDRSLARRVAAYRGGYLPEERRALERALHSGELLGLAATTALELGVDVSGLDAVVISGYPGTRASLWQQAGRAGRSGQGALAVLVARDDPLDTFLVHHPEALFDQPVESTVLDPDNPYVLAPHLCAAAAELPLTEEDLDLFGPACADVLPQLEAAKLLRRRTKAWHWTRRERAADLTDIRGTGGRPVQVVEAGTGRLLGTVDAGAAHSAVHEGAVHLHQGRTYLVRSLDLEDSVALVEQADPPYSTVARDTTSIAILETDTEIPWGAGRLCYGSVEVTNQVVSYLRRRLITGEVLGETKLDLPPRTLRTRAVWWTVTEDQLDAARITPEILGGSLHAAEHASIGMLPLFATCDRWDIGGVSVPLHPDTLLPTVFVYDGHPGGAGFAERAFHTARAWLTATREAIASCECEAGCPSCIQSPKCGNGNDPLHKRGAVRLLTVLLRGAPAETDAGEGAGG
>NZ_CP013219.1|WP_014674040.1|4624323_4624662_+|membrane-protein
MTAEAAVVLPVLVAFTMALVWGLLVVAARIECVDAARAGARAAARQDPAEAVVTVTREAAPRGARVTVAREGDRVRVTVAAKPPVLSGLPFEVREEAVALAEDTVGPREEGP
>NZ_CP013219.1|WP_078611786.1|4624100_4624301_+|DUF4244-domain-containing-protein
MFEKIRKAAVRVRGACRQDGGMVTSEYAMGIIAAVGFALLLYKVVTSGQVQAELQAIVKKALSARM
>NZ_CP013219.1|WP_058081388.1|4642293_4643499_+|DNA-polymerase-III-subunit-delta'
MTVWDDLVGQEKVSAVLDAAARDADALVTAAAADQPLPETSKMTHAWLFTGPPGAGRNQAARAFAAALQCVSPDRALGGAPGCGFCDGCHTALLGTHADVTSVAAVGSEILVKDMRDTVRKSFTSPANGRWQIILVEDAERLNEKSANAVLKAVEEPAPRTVWLLCAPSIEDVLPTIRSRCRHLNLRTPSVEAVADMLMRRDGIEPEVAASAARATQGHVDRARRLATDPAARERRAAVLKLPLRLDEVGACLRAAQELVDAAAEDAKQLAEEMDGKEAEELKAALGAAQGGRMPRGTAGVMKELEDMQKRRRTRTQRDSLDVALGDLTAFYRDVLALQLGTRVALANSDAEDALERLARAGTPESTLRRIEAIAACREALDRNVAPLLAVEAMTMALRAG
>NZ_CP013219.1|WP_058081389.1|4643647_4645261_+|alpha/beta-hydrolase
MHTRPSPRTRRTRGTRARTTARLAATLLTAAALLVSACSSGSSTTSSAGGTVEAALAALPRATPSALTPYYGQRLSWRDCGVPGFQCATMKAPLDYARPDAGTVRLAVARKKATGKGKPLGSLLVNPGGPGGSAVGYLQQYAGIGYPAQIRARYDMVAVDPRGVARSEPVQCLDGRQMDAYTQTDITPDDQRERDALVAADRKFAESCGARSARLLRHVSTVEAARDMDILRAALGDRKLNYVGASYGTFLGATYAGLFPRQVGRMVLDGAMDPTLDARRLNLDQTAGFETAFQAFAKDCVRHSDCPLGGRGTTPARVGANLKAFFRKLDTHPAPAGDADGRKLGESLATTGVIASMYDEASWEQLREALTSAMRENDGAGLLALADSYYERDAKGHYSNLMMANAAVNCLDLPPAFSGPEDVEKALPEFEKASPVFGPGLAWASLNCAYWPVRATGEPHRIEAKGAAPIVVVGTVRDPATPYRWARSLARQLSSSRLLTYDGDGHTAYGRGSACIDTAIDTYVLRGTPPPAGKRCS
>NZ_CP013219.1|WP_079088052.1|4645819_4646713_+|glycosyltransferase
MVEPRIAVAVVTMGNRPAEVDALLESVAKQDLAPARIVIVGNGCRLPEFAHRLSLPGEVTTIDVEENLGCPGGRNVALARLREFGDVDVVVELDDDGLLVDPDVLRRVRDLYAADPRLGIVGFRIADERGETQQRHVPRIGKSDPLRGGYVTGFLGGGHALRMAMLAETGDWPAEFFFAHEETDLAWRAADAGWKILYAPELLLQHPKTSPARHAIYYRVNARNRVWLVRRRLPLPLVPVHLGVWTLLTLARTRSTAGLKAWFGGFTEGLREHAGERRPMRWRTVWRLTRLGRPPVI
>NZ_CP013219.1|WP_058081390.1|4647165_4650849_+|tetratricopeptide-repeat-protein
MRRCELHFGLLGPPVLYDRPPHGISYDSSSSTSPEISGTAPGTVGTSPGPSGAAPRSSGPPTARRPAGKAGHDAPDNGVRAIGSPKVRALLAALLLEPGRVVSVEALKDALWGGAPPVSAQASLHNHVTRLRRLLDDPERLRAVPPGYVLRVDHGELDVHVFDARVAEARAAHARRDWPDVVRACASALALWRGTPLSGLPADIGGYALVQRLTEARLLLLEVRYDAELALGGARLAALVPELAALVAEHPLREAYHRQLMLALHRTGRQAEALAVHRDLRARLVEELGVEPGPTVREAHAEVLRGSGEQRGRDGEYGGSARPAGQGGQPRREDDSAAGDGDGDRFGTDTPGHAVGGAGSPAPQAPPASPSAPPTASAPSASSREGDGPAARQTPRPAQLPAPPAHFTGRADVRRELRRTLTEPSAPAPAVAVVSGMAGVGKSALALHVAHELRERFTDGQLYVNLHGATPGMTPLTATQALAALLRDLGAAPRNIPEHPDAAAALLRSLLAPARILLVLDDAANAAQVRPLLPAGPGCAVIVTSRSPLTALDGARRFPLSPLTGEDSAALLRAVSGRAGLDAGHALVELTGRLPLALRVVAARLAARRALTPDVLAGQLAETGGRLRHLEYDDLSVRRSLAVAHDALAAAEREADRDAALALRHIGALDLPTYGAPLIARLTGTDERRAEAALDRLVDVALLEETAYGRYAPHDLVRDFARELADAAPRPTASPAADAAGTDAFGEAPAPVGNESPTETPGTAGSGASGTTDADDSTGTTDLTAPERTSGPSAVCDGAPSAESASPVPDRAPGPGPASPLPDRTPGPGPGPAVPDRTPRPEDAPAVPDLAALRWYAAMAERVLTAVVEPGIDQDDRRRPTSAQPAEHAADVAALAPFESAEEAFAWGELELENVVTLVARNAGTDDPRTAAPLSALVRLLFPYVQRSGRVAEMEVLGRAALGAARRLGDPEAEAYALGDLAGLHFLTGRQNDALALTDQALEIWGRLGTASRIRRCLNNRGLLLEGLGRFAESGEALRQSLAYSRLLNDPYGEAVTRSHLGNLYEHTDPRAAIEQHRRSLAIGDEIGAVIVQHSAHCNIGYAHLTLGEPAAAARHFEESLRILGGHGDWHGESQTRLGLVRALRRLGQTERAADECAELLRRADARADRYMGGLALHQHGFLLRERGRRAEAYDAWRAAREALDGTDEQAILAELRELVSGGSAAW
>NZ_CP013219.1|WP_058081391.1|4650878_4652567_-|bifunctional-3'-5'-exonuclease/DNA-polymerase
MTDRWALAPAEDEGVDVAPLGPDGLPAGPVRRESDLAAAVRSRPEVTRWVWRSTPEVYPRLLATGVRVERCYDIEDAETLLLGHEGRYGEPRSAAAALARLRGGPVPPDPPQRAADPSAQSSLFEPVGSRLPLPDLLAVYADQVRRHEKTAHPDRMRLLTAAESAGMLVAAEMNHAGLPWSAEVHRELLHDLLGERYAGGGEPRRLAELADEVSAAFGRRVRPDLPADVIKAFAQAGIKVKSTRRWEIQSVDHPAVEPLLEYKKLYRIWVAHGWSWLQDWVRDGRFRPEFLAGGTVTGRWVTNGGGALQIPKVIRRAVVADPGWRLVVADADQMEPRVLAAISRDPGLMEVAGRESDLYQSVSDRAFSGDRNQAKLAVLGAIYGQTSGDGLKNLAALRRRFPKAVAYVDEAARAGEEGRLVRTWLGRTCPPVARAGEDAAEEAGIPIGEEEPEGQTGWGPGSASTGSRARGRFARNFVVQGSAADWALLLLAALRRACAELKAELVFFQHDEVIVHCPAEEADAVVRAIRESAALAGRLTFGDTPVRFPFTTAVVRCYADAK
>NZ_CP013219.1|WP_058081392.1|4652625_4653405_-|Clp-protease
MATNPNITASVRLDDLIEAIKKAHSEPLDQLQDAVIAADHLGDVADHLIGHFVDQARRSGASWTDIGRSMGVTRQAAQKRFVPKESTDLDLSQGFSRYTPRARNVVMAAHNEAVAARNAEGRPEHLLLGLLAEPEGLAAKAITAQGVPLDAVRQAATAALAPASDDVPDLVPYGPEAKKVLELTFREALRLGHNYIGTEHLLLALLEHENGQGVLSGLGITKAATEEYVGKVLSLLLEQNKETAAAAEPATGAAEPDQD
>NZ_CP013219.1|WP_058081393.1|4653533_4654676_+|DUF2786-domain-containing-protein
MLSAGRGTIDDVTSTASTVERAFRAALYDDTDTGLDTGASLLAADPGADAELTRRGEDFVAGAWQRGWQPADVVRLVRRELDDVHVRLAAALIRAQAGRDRPRGRRWTDQLAALPAGPERTTDRFSHATAVLELYRLLLRLPSLEPLDEEPRRAPGPAASRMLTRIRALLAKAEATGYPEEAEALSAKAQELMARHSVDEALLAAEAPAPDAPGACRIGVEPPYEQAKAVLLDAVATANHCRAVWNEPLGFSTVVGFEADLEAVELLYTSLLVQATHAMTKAEAAQRAGGRKRTKTFRQSFLAAYAHRVGDRLAAAAETQVTQDLLPVLATRETAVTGRLERMFPETTTTRLRGVSDAAGWTEGARAADQAQVRARPRLG
>NZ_CP013219.1|WP_014674091.1|4654994_4655510_-|DUF4232-domain-containing-protein
MRAIPLTVTALAAALLLTACNDSGGNKTGKSGSACEIGGVSLEIGAASVAPAAGDTGEIPVSITNQSAPCTLDDFPDIELSGGGAKARVPVLKGAKAQKLKLAKGDSASFSISYVRGAEGAKNALAAQTVKITLPGSDTGRSFPWKYGPVAGKADGSGPDASVSAFQQVGD
>NZ_CP013219.1|WP_058083960.1|4655639_4656092_-|hypothetical-protein
MGLAGALTLTACSGGGSGGGDGTSASPSTNATAAPSPGAGSPAGASTRLQGSWITTADGKIVALVVTGKKAGIFATGGTMCSGTAGAEDGMQMIHLTCAGGDKDRTTGMVDSVNGTTLKVTWSGKTGQETYTKAEGGRLPSGLPTVPVRR
>NZ_CP013219.1|WP_107112883.1|4656163_4656490_-|30S-ribosomal-protein-S14
MARRLAERRGPAERPEPAGRREPVGRRGLDERREPAGPHGTPAPPVRVCDRGRADGRPCGHLPAIGLSRVGPRGSAHRGFPPGLRKSSWSLLVACAAGRPARAAGRYR

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Crispr_ID: NZ_CP013219_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013219_8

5011348-5011471

Unclear

Consensus_repeat	Method
GCTGCAACTCCTTGGGGGCCGGGGGGGAACCGTGCGACCGGGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013219_8

>merge|NZ_CP013219|8|5011348-5011471|CRISPRCasFinder
GCTGCAACTCCTTGGGGGCCGGGGGGGAACCGTGCGACCGGGCTCCACGCATCCGCGTGCGGTGCGGTGTGGTCGGCGGGCGCTGCAACTCCTTGGGGGCCGGGGGGAACCGTGCGACCGGGCT

>NZ_CP013219|8|6|5011348-5011471|CRISPRCasFinder
GCTGCAACTCCTTGGGGGCCGGGGGGGAACCGTGCGACCGGGCT	CCACGCATCCGCGTGCGGTGCGGTGTGGTCGGCGGG
CGCTGCAACTCCTTGGGGGCCGGGGGGAACCGTGCGACCGGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013219.1\|WP_058083982.1\|5009902_5011324_+\|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase	unknown	unknown	gnl\|CDD\|238576
NZ_CP013219.1\|WP_058081566.1\|5012029_5013193_+\|alanine-racemase	unknown	unknown	gnl\|CDD\|143481
NZ_CP013219.1\|WP_014674398.1\|5004560_5005490_-\|DUF389-domain-containing-protein	unknown	unknown	gnl\|CDD\|129372
NZ_CP013219.1\|WP_014674407.1\|5015179_5015377_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058081568.1\|5018563_5018821_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_014674410.1\|5016973_5017474_+\|ribosomal-protein-S18-alanine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|273701
NZ_CP013219.1\|WP_014674409.1\|5016287_5016944_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	unknown	unknown	gnl\|CDD\|274750
NZ_CP013219.1\|WP_058083981.1\|5000873_5001746_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_041665442.1\|5009460_5009832_+\|holo-ACP-synthase	unknown	unknown	gnl\|CDD\|234610
NZ_CP013219.1\|WP_058081567.1\|5014537_5015050_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl\|CDD\|376771
NZ_CP013219.1\|WP_079088064.1\|5006655_5008503_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP013219.1\|WP_058083983.1\|5015608_5016163_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_041665440.1\|5005511_5006480_-\|type-I-pantothenate-kinase	unknown	unknown	gnl\|CDD\|235466
NZ_CP013219.1\|WP_014674397.1\|5003191_5004550_+\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237672
NZ_CP013219.1\|WP_014674395.1\|5002014_5002458_+\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NZ_CP013219.1\|WP_058081569.1\|5019119_5020151_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380519
NZ_CP013219.1\|WP_014674396.1\|5002500_5003013_+\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NZ_CP013219.1\|WP_014674405.1\|5013312_5014572_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP013219.1\|WP_058081565.1\|5008578_5009361_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187605
NZ_CP013219.1\|WP_014674411.1\|5017466_5018567_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl\|CDD\|236585

Protein	Function_ID	Function_description	E-value
NZ_CP013219.1\|WP_058083982.1\|5009902_5011324_+\|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	1.27556e-60
NZ_CP013219.1\|WP_058081566.1\|5012029_5013193_+\|alanine-racemase	gnl\|CDD\|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	1.77114e-161
NZ_CP013219.1\|WP_014674398.1\|5004560_5005490_-\|DUF389-domain-containing-protein	gnl\|CDD\|129372	TIGR00271, Uncharacterized_protein_MJ0678, uncharacterized hydrophobic domain. This domain is in a family of archaeal proteins that includes AF0785 of Archaeoglobus fulgidus and in several eubacterial proteins, including the much longer protein sll1151 from Synechocystis PCC6803.	3.18346e-53
NZ_CP013219.1\|WP_014674409.1\|5016287_5016944_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	gnl\|CDD\|274750	TIGR03725, T6A_YeaZ, tRNA threonylcarbamoyl adenosine modification protein YeaZ. This family describes a protein family, YeaZ, now associated with the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family may occur as fusions with ygjD (previously gcp) or the ribosomal protein N-acetyltransferase rimI, and is frequently encoded next to rimI. [Protein synthesis, tRNA and rRNA base modification].	1.38681e-63
NZ_CP013219.1\|WP_014674410.1\|5016973_5017474_+\|ribosomal-protein-S18-alanine-N-acetyltransferase	gnl\|CDD\|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR\|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	6.04225e-30
NZ_CP013219.1\|WP_041665442.1\|5009460_5009832_+\|holo-ACP-synthase	gnl\|CDD\|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	1.59504e-46
NZ_CP013219.1\|WP_058081567.1\|5014537_5015050_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl\|CDD\|376771	pfam02367, TsaE, Threonylcarbamoyl adenosine biosynthesis protein TsaE. This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).	2.14619e-47
NZ_CP013219.1\|WP_014674405.1\|5013312_5014572_+\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	5.47029e-30
NZ_CP013219.1\|WP_041665440.1\|5005511_5006480_-\|type-I-pantothenate-kinase	gnl\|CDD\|235466	PRK05439, PRK05439, pantothenate kinase; Provisional.	0
NZ_CP013219.1\|WP_014674397.1\|5003191_5004550_+\|phosphoglucosamine-mutase	gnl\|CDD\|237672	PRK14318, glmM, phosphoglucosamine mutase; Provisional.	0
NZ_CP013219.1\|WP_014674395.1\|5002014_5002458_+\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	3.93594e-101
NZ_CP013219.1\|WP_058081569.1\|5019119_5020151_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|380519	cd06296, PBP1_CatR-like, ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group includes the ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group belongs to the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.77529e-112
NZ_CP013219.1\|WP_014674396.1\|5002500_5003013_+\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	2.43165e-72
NZ_CP013219.1\|WP_058081565.1\|5008578_5009361_-\|SDR-family-oxidoreductase	gnl\|CDD\|187605	cd05347, Ga5DH-like_SDR_c, gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs. Ga5DH catalyzes the NADP-dependent conversion of carbon source D-gluconate and 5-keto-D-gluconate. This SDR subgroup has a classical Gly-rich NAD(P)-binding motif and a conserved active site tetrad pattern. However, it has been proposed that Arg104 (Streptococcus suis Ga5DH numbering), as well as an active site Ca2+, play a critical role in catalysis. In addition to Ga5DHs this subgroup contains Erwinia chrysanthemi KduD which is involved in pectin degradation, and is a putative 2,5-diketo-3-deoxygluconate dehydrogenase. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107,15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.03177e-75
NZ_CP013219.1\|WP_079088064.1\|5006655_5008503_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP013219.1\|WP_014674411.1\|5017466_5018567_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl\|CDD\|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	0

>NZ_CP013219.1|WP_058083982.1|5009902_5011324_+|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase
METVRAAERALMARLPEGALMQRAAAGLAAACAELLGRVYGSRVVLLVGSGDNGGDALYAGARLARRGAGVTAVLLTPGRAHAGGLAALRRAGGTVATADSAAVDELVLRADLVVDGIVGIGGKGGLRPDAERLAGVVARSRAAVVAVDLPSGVDADTGEVRGAALRADLTVTFGAYKPGLLVDPAREYAGVVRLVGIGLEPPPAEAVLEALQHADVARLLPLPTGESDKYRRGVVGIAAGSARYPGAAVLAVSGALRGGAGAVRYVGPAGDAVIARFPETLVSDAGPAKAGRVQAWVVGPGAGDDAAAVAEVLEADVPVLLDADGLRLADRDAVRRRTSPTLMTPHAGEAAALLGVRREEVEAARLAAVRELAAVYRATVLLKGSTTLVADFAGGPVRVNATGTPWLATAGSGDVLSGLAGSLLAAGLRAPDAGSVAAYLHGLAGRFAAQGAPTGAHDVASHIPRAWRDVRG
>NZ_CP013219.1|WP_041665442.1|5009460_5009832_+|holo-ACP-synthase
MSIIGVGIDVAEIDRFRASLERTPGLADRLFVERELLLPSGDRRGIASLAARFAAKEALAKALGAPSGLQWTDAEVYVEDTGQPRLRVKGTVAARAAELGVRAWHVSLSHDAGVASAVVVAEG
>NZ_CP013219.1|WP_058081565.1|5008578_5009361_-|SDR-family-oxidoreductase
MTSSHAYLSGLFSLDGRVAVVTGGSSGIGRAIAGALARAGASVVIVARRKTELSSTVDELTADGCRAAWVSGDLGTRDGVRAAAEEAAAVFGEPDILVNSAGINLRPPMGELGEDVWDTTMAVNLDAPFLLGQRFGPGMAERGFGRIIHVTSQQAHRAFVQSGAYGVSKGGLESLARSQAEAWSPHGVTCNTLVPGFVLTPLNRRLQSDPEKVAALAARTMVGRNGLAEDFAGAAVFLAGRASAYITGQSIHVDGGFSVH
>NZ_CP013219.1|WP_079088064.1|5006655_5008503_+|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYVGSQSALDVVMAGLKRLEYRGYDSAGVAVLADGGLAAAKKAGKLVNLEKELVERPLPAGTTGIGHTRWATHGGPTDANAHPHLDNAGRVAVVHNGIIENFAVLRAELAERGHELNSETDTEVVAHLLAEEFSATADLAEAMRLVCRRLEGAFTLVAVHADDPDVVVGARRNSPLVVGVGEGEAFLASDVAAFIAHTRSAIELGQDQVVELRRDGVTVTGFDGRPAEVHSYHVDWDASAAEKGGYDYFMLKEIAEQPKAVADTLLGRIDPSGSLTLDEVRISPSELREIDKVVIVACGTAFHAGLIAKYAIEHWTRIPCEVELASEFRYRDPILDGRSLVIAVSQSGETMDTLMALRHAREQGSKVLAICNTNGSTIPRESDAVLYTHAGPEVAVASTKAFLTQLVACYLVALYLGQVRGTKWGDEIQAVIKDLSRISEEVERVLETMEPVRALARTLAGKDTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEEDVPVVVVVPSPRGRSVLHDKIVSNIQEIRARGARTIVIAEEGDEAVVPYADHLIRIPATPTLLQPLVATVPLQVFACELATARGNEVDQPRNLAKSVTVE
>NZ_CP013219.1|WP_041665440.1|5005511_5006480_-|type-I-pantothenate-kinase
MPRSAHRHRPEATPYVDLTRAEWSALRDKTPLPLTAEEVEKLRGLGDVIDLDEVRDIYLPLSRLLNLYVGATDGLRGALNTFLGEKGSQSGTPFVIGVAGSVAVGKSTVARLLQALLSRWPEHPRVELVTTDGFLLPTRELEARGLMSRKGFPESYDRRALTRFVADIKAGKGEVSAPVYSHLIYDIVPGEKLTVRRPDILIVEGLNVLQPALPGKDGRTRVGLADYFDFSVYVDASADDIENWYLNRFKKLRQTAFQNPNSYFRKYTQVSEEEALDYARTLWRTINKPNLVENIAPTRGRATLILRKGQDHKVQRLRLRKL
>NZ_CP013219.1|WP_014674398.1|5004560_5005490_-|DUF389-domain-containing-protein
MLHLRLITPAERTDEVVRLIETTVGTTHLVVLPGAARDPAGDVVLCDVAREAGDELIAGLRRLGLDDTGSIAVETIDLSLSRRAEEAEDEAPGEGADAVLWEGLTEATHEESTLSVTYAAFITLATMIAACGVVLDNAILIVGAMAVGPEFGPLAGICTALVRRRPRLAWRSLTALLVGFALAMAVTAGFSLLMDAVGLFSKARLEADRPNTGFIYAPDWFSFVVAVLAGIAGTLSLTSAKSGALVGVAISVTTVPAAANAAVALIYDDTHQAARSSEQLLLNLLGIVLAGTLTLLAQKSLWKRHRRHP
>NZ_CP013219.1|WP_014674397.1|5003191_5004550_+|phosphoglucosamine-mutase
MGRLFGTDGVRGVANADLTAEMALGLSVAAAHVLAEAGTFEGHKPTAVVGRDPRASGEFLEAAVVAGLASAGVDVLRVGVLPTPAVAYLTGALGADLGVMLSASHNAMPDNGIKFFARGGHKLADELEDRIEAVYDAHRHGEPWERPTGAGVGRVRSYEEGFESYVAHLLAVLPNRLDGLKIVLDEAHGAASGVSPEAFARAGAQVVTIGAEPDGLNINDGCGSTHLGKLKAAVVEHGADLGIAHDGDADRCLAVDHTGEEVDGDQILAVLALAMRERSALRSDTVVATVMSNLGFKLAMERAGIRLVQTAVGDRYVLEEMKEHGYALGGEQSGHVIILDHATTGDGTLTGLLLAARVAETGRTLRELASVMERLPQVLVNVPDVDKSRVRTSADLAAAVSEAERELGETGRVLLRPSGTEPLVRVMVEAADIEQARSVAGRLADAVKSALG
>NZ_CP013219.1|WP_014674396.1|5002500_5003013_+|30S-ribosomal-protein-S9
MAETTAEQPLEELDIDSYTTESEVPVEGEYTSESLASRFGEPQPAAGLGRRKNAIARVRIVPGTGKWKINGRTLEDYFPNKVHQQEVNEPFKVLELDGRYDVIARIAGGGVSGQAGALRLGVARALNEADVDNNRGPLKKAGFLRRDDRAVERKKAGLKKARKAPQYSKR
>NZ_CP013219.1|WP_014674395.1|5002014_5002458_+|50S-ribosomal-protein-L13
MRTYSPKPGDVTRQWHVIDAQDVVLGRLATTAATLLRGKHKPIYAPHVDAGDFVIIINADKVHLSGNKRTQKMAYRHSGYPGGLRSVRYDELLDKNPEKAIEKAVKGMLPKNSLGRQMLSKLKVYKGDQHPHAAQQPVPFEITQVAQ
>NZ_CP013219.1|WP_058083981.1|5000873_5001746_-|hypothetical-protein
MSYGQGGPQSQWDPWKPNSQQPWNSGSDDGTPDWAALAEASETRNKRRKLLFIAGGALATVAIGTAVAMAVVSANGGDPQAGPSNLPASGSLPGTGTATPSFAPTSAPPPLDPTDFISSAKKDTAPLSPDTLFPGTQLTMGGTVYKKGPTADTESCAGAAGGTLPKILTGNGCTRLMRVTYTNGGIAVTVGVAVFDDADRAAKAKGRTDDRSIVRSLFGKGVKPFCDGAFCRSTRNAYGRYAYFTISGFTSGKDVTTKDTKVFAAGNDLAQFTANQIHRRGQVQASAAAR
>NZ_CP013219.1|WP_058081566.1|5012029_5013193_+|alanine-racemase
MSETPAVPTAALRARAEIDLGALRANVRALRARAEGAALMAVVKSDGYGHGAVPCARAALAAGASWLGTATAEEALALRAAGLPGRILCWLWVPGGPWRQAIEADIDVSLSGMWALREVVEAARAAGRTARVHLKADTGLGRNGCQPGEDWAELVGAALRAEAEGLVRVTGVWSHFACADEPGHPSVAAQLTRFREMLAYAEEQGVRPEVRHIANSPATLTLPEAHFDLVRTGIALYGVSPSPELGTPADFGLHPVMTLSASLALVKHTPAGHGVSYGHHYVTPGETTLGLVPVGYADGIPRHASGTGPVLVGGKWRTIAGRVAMDQFVVDLGGDEPPVGSEAVLFGPGDRGEPTAEDWAQACGTIAYEIVTRIGTRVPRVYVNASM
>NZ_CP013219.1|WP_014674405.1|5013312_5014572_+|alpha/beta-hydrolase
MSESSAEVVADVVASAAAASAAGAAGSWRRATGLAGAAIGVLAAGAAAGVAIERMTVGRGMRRRARLALDAAGPYGTLRGTPGKAYADDGTELYYEVDEAEPDAGPNVSPRRRRLFGRKAPAPVTVVFCHGYCLSMDSWHFQRAALRGVVRTVHWDQRSHGRSGRGVAQTRDREPVTIDQLGRDLKAVLDAAAPDGPLVLVGHSMGGMTMMALAAQYPELIRDRVVATAFVGTSSGRLGEVNFGLPVAGVNAVRRILPGVLKALGQQAEWVEKGRRATADLFAGIIKRYSFAGRDVDPAVERFAERMIESTPIDVVAEFYPAFTDHDKTGALVCFRDMPVLVLAGVQDLVTPSEHSEAIADLLPDAELVLVPDAGHLVMLEHPEVVTDRLADLLTRAGAVPAGATVSGYGSTSSTAQPR
>NZ_CP013219.1|WP_058081567.1|5014537_5015050_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MEAPAAPHNPAETQLTVTSPEQMRELGRRLAKLLRAGDLVMLTGELGAGKTTLTRGLGEGLGVRGAVTSPTFVIARVHPSLGDGPPLVHVDAYRLSGGLDEMEDLDLDVSLPDSVIVVEWGEGKVEELTDDRLQVVIHRAVGDTTDEVRHVTVTGLGERWSETDLEPLSG
>NZ_CP013219.1|WP_014674407.1|5015179_5015377_+|hypothetical-protein
MPTVGPVSMRDLLAACAAADAVSRPPRPEHPDGARGPAEQVADAAWARPAETAPQPSGRASRHGA
>NZ_CP013219.1|WP_058083983.1|5015608_5016163_-|hypothetical-protein
MAGTSSGIVAALTAAALGTVGFLAYRAQATVPAGLGAGPVAHATPTSKAPRDRHHPTALPNGSGTGERVVYSVDDDRVWLVTPRNRVQRTFPVRPGTVDPPAGTYWVTSRSSTATGTDSVPIEHVVRFTSVDGVTVGFSAAVNGGAEGLTADSGVKTGGIRETRADGDAMWNFATIGVKVVVIR
>NZ_CP013219.1|WP_014674409.1|5016287_5016944_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB
MLLLALDTATPAVTVALHDGTDVIASSSQVDARRHGELLLPAVDRVLAEAGLKLEAVTGIVVGTGPGPYTGLRVGLMTADTFGLALGVPVHGLCTLDGLAYAADIEKGPFVVATDARRKEVYWATYADSRTRLTGPAVDRPADIAERVAGLPAVGAGALLYPDTFPRAHEPEHVSAASLASLAAEKLAAGEELTAPRPLYLRRPDAQVPKNYKVVTPK
>NZ_CP013219.1|WP_014674410.1|5016973_5017474_+|ribosomal-protein-S18-alanine-N-acetyltransferase
MRWWDIDPVLGLERDLFPEDAWSRGMFWSELAHSRGPEATRCYLVAESADGRVVGYAGLAAAGDLADVQTIAVARDHQGTGLGARLLTELLRAATAFECHEVMLECRVDNLPAQKLYERFGFTPIGFRRGYYQPGNVDALVMRLTTEPGSGSAAGSASVQGTDIND
>NZ_CP013219.1|WP_014674411.1|5017466_5018567_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MTDSRDEPLVLGIETSCDETGVGIVRGTTLLADAVASSVDEHARFGGVVPEVASRAHLEAMVPTIDRALKEAGVSAKDLDGIAVTAGPGLAGALLVGVSAAKAYAYALGKPLYGVNHLASHICVDQLEHGPLPEPTMALLVSGGHSSLLLSTDITSDVRPMGSTIDDAAGEAFDKIARVLNLGFPGGPVIDRYAKEGDPQAIAFPRGLTGPRDPAYDFSFSGLKTAVARWIEARRAAGEEVPVRDVAASFQEAVVDVLTRKAVRACKDEGVDHLMIGGGVAANSRLRALAQERCEAAGIRLRVPRPKLCTDNGAMVAALGAEMVARNRAASSWDLSADSSLPVTDPHVPGHDHDHVHEVSKENLYS
>NZ_CP013219.1|WP_058081568.1|5018563_5018821_+|hypothetical-protein
MTVALMWEARAAEGRGADLLAWVREQALAAEPLRRETFRAPRDRVLVVTWWDAPYDAPLPELPEPDPELVTRAVHRWRFEAVAED
>NZ_CP013219.1|WP_058081569.1|5019119_5020151_+|LacI-family-transcriptional-regulator
MKPSKPAGTQTATLAEIAREAGVSAPTVSKVLNGRADVSPATRTRVEELLRAYGYRRRRAEASRSPLIDVVFHELESAWAMEVIRGVENVARDAGLSVVLSESAGRLTPGRTWADQVAARRPHGVVLVLSELDESQRALLTSRSIPFVVMDPAGDPGPDVPSIGATNWQGGLAATRHLVELGHTRIGAISGPTRMMCSRARVDGYRAALETAGLPVDPSLVVAGDFHHDAGYRLGLELLRRPDRPTAVFAGNDLQALGLYEAARELGLRVPEDLSVVGFDDLPVARWVGPPLTTVRQPLTEMAEAAARLVLELGSEREERAATRVELATSLVVRSSTDAPPAG

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Crispr_ID: NZ_CP013219_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013219_9

5278085-5278189

Orphan

Consensus_repeat	Method
AACTGCGCGACCAGCCACAGCGCACCGGCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013219_9

>merge|NZ_CP013219|9|5278085-5278189|CRISPRCasFinder
AACTGCGCGACCAGCCACAGCGCACCGGCACCGGGCAACGGCCCGGGGCCCGGCGCCCTGAAGGGGCGCGGGGAACTGCGCGACCAGCCACAGCGCACCCGCACC

>NZ_CP013219|9|7|5278085-5278189|CRISPRCasFinder
AACTGCGCGACCAGCCACAGCGCACCGGCACC	GGGCAACGGCCCGGGGCCCGGCGCCCTGAAGGGGCGCGGGG
AACTGCGCGACCAGCCACAGCGCACCCGCACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013219.1\|WP_058081693.1\|5279657_5281196_+\|histidine-ammonia-lyase	unknown	unknown	gnl\|CDD\|236484
NZ_CP013219.1\|WP_058081691.1\|5277267_5278062_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|181069
NZ_CP013219.1\|WP_058081688.1\|5268759_5270532_-\|biotin/lipoyl-binding-protein	unknown	unknown	gnl\|CDD\|227111
NZ_CP013219.1\|WP_058081687.1\|5267499_5268396_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP013219.1\|WP_058081694.1\|5284513_5285959_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|223650
NZ_CP013219.1\|WP_014674609.1\|5282091_5282418_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058084002.1\|5287106_5290313_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173812
NZ_CP013219.1\|WP_014674611.1\|5283109_5284357_+\|L,D-transpeptidase	unknown	unknown	gnl\|CDD\|380079
NZ_CP013219.1\|WP_058081692.1\|5278426_5279569_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|128563
NZ_CP013219.1\|WP_014674600.1\|5272314_5272524_-\|acyl-CoA-carboxylase-subunit-epsilon	unknown	unknown	gnl\|CDD\|379386
NZ_CP013219.1\|WP_014674603.1\|5275356_5276481_+\|adenylate/guanylate-cyclase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NZ_CP013219.1\|WP_058081689.1\|5270924_5271482_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_014674598.1\|5271453_5272044_-\|septum-formation-inhibitor-Maf	unknown	unknown	gnl\|CDD\|178901
NZ_CP013219.1\|WP_014674610.1\|5282554_5282872_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058081690.1\|5274280_5275141_+\|biotin--[acetyl-CoA-carboxylase]-ligase	unknown	unknown	gnl\|CDD\|223417
NZ_CP013219.1\|WP_014674613.1\|5286081_5286765_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP013219.1\|WP_014674614.1\|5286884_5287145_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_014674608.1\|5281251_5282031_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058084001.1\|5276455_5277013_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237057
NZ_CP013219.1\|WP_014674601.1\|5272556_5274170_-\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|227136

Protein	Function_ID	Function_description	E-value
NZ_CP013219.1\|WP_058081693.1\|5279657_5281196_+\|histidine-ammonia-lyase	gnl\|CDD\|236484	PRK09367, PRK09367, histidine ammonia-lyase; Provisional.	0
NZ_CP013219.1\|WP_058081691.1\|5277267_5278062_+\|enoyl-CoA-hydratase	gnl\|CDD\|181069	PRK07657, PRK07657, enoyl-CoA hydratase; Provisional.	2.80986e-75
NZ_CP013219.1\|WP_058081688.1\|5268759_5270532_-\|biotin/lipoyl-binding-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP013219.1\|WP_058081687.1\|5267499_5268396_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	3.05237e-76
NZ_CP013219.1\|WP_058081694.1\|5284513_5285959_+\|FtsX-like-permease-family-protein	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	2.70063e-15
NZ_CP013219.1\|WP_014674611.1\|5283109_5284357_+\|L,D-transpeptidase	gnl\|CDD\|380079	pfam17964, Big_10, Bacterial Ig domain. This entry represents a bacterial Ig-like domain found associated with transpeptidase domains.	1.51583e-75
NZ_CP013219.1\|WP_058081692.1\|5278426_5279569_+\|GGDEF-domain-containing-protein	gnl\|CDD\|128563	smart00267, GGDEF, diguanylate cyclase. Diguanylate cyclase, present in a variety of bacteria.	4.49744e-40
NZ_CP013219.1\|WP_014674600.1\|5272314_5272524_-\|acyl-CoA-carboxylase-subunit-epsilon	gnl\|CDD\|379386	pfam13822, ACC_epsilon, Acyl-CoA carboxylase epsilon subunit. This family includes the epsilon subunits of propionyl-CoA carboxylase, EC:6.4.1.3, and acetyl-CoA carboxylase, EC:6.4.1.2. These enzymes are involved in the biosynthesis of long-chain fatty acids. The epsilon subunit is necessary for an efficient interaction between the alpha and beta subunits of these enzymes.	4.06401e-09
NZ_CP013219.1\|WP_014674603.1\|5275356_5276481_+\|adenylate/guanylate-cyclase-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	9.75181e-29
NZ_CP013219.1\|WP_014674613.1\|5286081_5286765_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	5.29988e-106
NZ_CP013219.1\|WP_014674598.1\|5271453_5272044_-\|septum-formation-inhibitor-Maf	gnl\|CDD\|178901	PRK00148, PRK00148, Maf-like protein; Reviewed.	2.7851e-94
NZ_CP013219.1\|WP_058084002.1\|5287106_5290313_+\|S8-family-serine-peptidase	gnl\|CDD\|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	5.39927e-77
NZ_CP013219.1\|WP_058081690.1\|5274280_5275141_+\|biotin--[acetyl-CoA-carboxylase]-ligase	gnl\|CDD\|223417	COG0340, BirA, Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism].	2.33479e-61
NZ_CP013219.1\|WP_058084001.1\|5276455_5277013_-\|hypothetical-protein	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	6.21038e-06
NZ_CP013219.1\|WP_014674601.1\|5272556_5274170_-\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0

>NZ_CP013219.1|WP_058081691.1|5277267_5278062_+|enoyl-CoA-hydratase
MGEERFGEFVLVRRHGHVAELVLDRPKAMNAVSTEMARSLAGACAALSVDRDARVVVLTSSHERAFCVGADLKERNSFTDADLVRQRPVARGAYTGVLELPMPTIAAVHGFALGGGFELALSCDLIVADRTAVVGLPEVSVGVIPGGGGTQLLPRRVGAARAAELIFSARRVEAAEAAELGLVDRLVEPGRDREEALALAERIAGNSPVGLRAAKRALRLGHGLDLRAGLEVEDAAWRSVAFSGDRAEGVAAFNEKRKPQWPGE
>NZ_CP013219.1|WP_058084001.1|5276455_5277013_-|hypothetical-protein
MLLAAGGLALAAGVLSLVRAAPDAGVGAPGTAEAEPRLGAGGGSADRSADAAATIAAAPTALPSATSAMGGRSLAPTPAGSPVRTAAPGPGPGTATTASGGTAVPTARTSRTPGPPSATSRPPAPTASAPRPAPATSTPTPAPSHGPAEPEPRPGGVCVPVIGLCVDVLGDSPRRPAATAGRRGG
>NZ_CP013219.1|WP_014674603.1|5275356_5276481_+|adenylate/guanylate-cyclase-domain-containing-protein
MTVDDTGSGAGGDGRVDPHAPETGDDPLALRLEQLILGAERRYTPFQAARSAGVSMELASRFWRAMGFADIGQAKALTEADVLALRRLAGLVEAGLLSEAMAVQVARSTGQTTARLAEWQIDSFLEGLTEPPEPGMTRTEVTYPIVELLLPELEEFLVYVWRRQLAASAGRVVQTADDEEMVDRRLAVGFADLVGFTRLTRRMEEEELGELVEAFETTAADLVAARGGRLIKTLGDEVLYAADDAGVAADIALRLVETLANDETMPELRVGMAFGTVTTRMGDVFGTTVNLASRLTSIAPRDAVLVDSAFAEELIRSGEAPASEAEAAEAAAAAEKEGEDPPVYRFALQPMWQRPVRGLGVVEPWLLTRRDGQP
>NZ_CP013219.1|WP_058081690.1|5274280_5275141_+|biotin--[acetyl-CoA-carboxylase]-ligase
MTPQNPSDDSRWSDLDRPPLNGAALRRGLVREEGLYCDIEVVQRTGSTNSDLAALAAAGNADEGAVLVAEEQTSGRGRLDRRWTAPPRSGLFFSVLLKPTEVPVARWGWLPLLTGVAVATGLSRAAGVDTALKWPNDLLVTVGGEERKAGGILAERAGDDGVVIGVGINVTLRADELPVPQAGSLALAGAPVTDRDPLLRAVLRSLEGWYGRWRATGGDPSASGLQETYTAGCATLGRVVRAELPGDRSVVGEAVALDGDGRLIIATENGVQEPVGAGDIVHLRPA
>NZ_CP013219.1|WP_014674601.1|5272556_5274170_-|acyl-CoA-carboxylase-subunit-beta
MSEPEERHEIQEIDIHTTAGKLADLQRRIHEATHAGSERAVEKQHAKGKLTARERIELLLDEGSFVELDEFARHRSTNFGLERNRPYGDGVVTGYGTVDGRPVAVFSQDFTVFGGALGEVYGQKIVKVMDFALKTGCPVIGINDSGGARIQEGVASLGAYGEIFRRNTHASGVIPQISLVVGPCAGGAVYSPAITDFTVMVDQTSHMFITGPDVIKTVTGEDVGFEELGGARTHNTASGVAHHMAGDEKDAIEYVKQLLSYLPSNNLSEPPVFPEEADLSPSDEDRELDTVVPDSANQPYDMHTVIEHVLDDGEFFETQALFAPNILTGFGRVEGHPVGVVANQPMQFAGCLDITASEKAARFVRTCDAFNIPVLTFVDVPGFLPGVDQEHDGIIRRGAKLIYAYAEATVPLITVITRKAFGGAYDVMGSKHLGADLNLAWPTAQIAVMGAQGAVNILHRRTIAEAEASGEDVEVVRARLIQEYEDTLLNPYVAAERGYVDAVIMPSDTRAHIVRGLRQLRTKRESLPPKKHGNIPL
>NZ_CP013219.1|WP_014674600.1|5272314_5272524_-|acyl-CoA-carboxylase-subunit-epsilon
MNIKVVRGNPTPEELAAALAVVRARAAAAAATPSGAEPPRDAWSDPSRIAAHRVPRPGPTSWTRTYWPS
>NZ_CP013219.1|WP_014674598.1|5271453_5272044_-|septum-formation-inhibitor-Maf
MLASQSPARLALLRQAGLAPEVIVSGVDEDAVTAPTPAELALALAEAKASVVAARPEVQGALVIGCDSVLELDGQALGKPADAEEATARWKSMRGRAGVLQTGHCVWDTEAKRYVSATASTVVRFGEPSDEEIAAYVASGEPLHVAGAFTLDGRSAPFIEGIDGDHGNVIGISLPLLRRLLAELGVGITELWAPER
>NZ_CP013219.1|WP_058081689.1|5270924_5271482_+|hypothetical-protein
MAVVLLAEAVFIAALNWFLGVVVDRQDMSLAGLDPGVMSTSSKIGGVVFGLYFALCALVAALVAVRDRAPVGLGRVLLISAAVVHGLLGAFAWGLVGWTAFLFMVVVLGLIVLLLMTYDRAGGPEGAAPGGTPGEGAGPAARAEPGVAPAGAGAPVSRTDEPQDGDDEPQDSVPARIIVPVPTTP
>NZ_CP013219.1|WP_058081688.1|5268759_5270532_-|biotin/lipoyl-binding-protein
MRKVLIANRGEIAVRVARACRDAGIASVAVYADPDRDALHVRAADEAFALGGDTPATSYLVIEKILNAARESGADAVHPGYGFLSENAEFAQAVLDAGLIWIGPPPQAIRDLGDKVAARHIAQRAGAPLVAGTPDPVSGADEVVAFAKEHGLPIAIKAAFGGGGRGLKVARTLEEVPELYDSAVREAVAAFGRGECFVERYLDRPRHVETQCLADKHGNVVVVSTRDCSLQRRHQKLVEEAPAPFLSEEQVAELYRASKAILKEAGYEGAGTCEFLVGQDGTISFLEVNTRLQVEHPVTEEVAGIDLVREMFRIADGEELGYGDPVLRGHSFEFRINGEDPGRNFLPAPGTVTRFDPPSGPGVRLDAGVEAGSVIGPAWDSLLAKLVVTGRTRKEALERAARALDEFQVEGMATAIPFHRVVVRDPAFAPELTGSQDPFTVHTRWIETEFVNEIKPFAAPADVEAEEELGRETVVVEVGGKRLEVSLPSSLGMSLARTGLAAGAKPKRRAAKKSGPVASGDTLASPMQGTIVKIAVEEGQEVKEGDLVVVLEAMKMEQPLNAHKTGTIKGLTAEVGASITSGAAICEIKD
>NZ_CP013219.1|WP_058081687.1|5267499_5268396_+|DeoR/GlpR-transcriptional-regulator
MVRANGAVSLRELARVVQTSEVTVRRDVRALEAEGLLDRRHGGAVLPGGFTRESGFPQKSHLATAEKTAIADLAASLVEEGEAIVVGAGTTTQELARRLARVPGLTVVTNSLLVAQALAHANRVEVVMTGGTLRGSNYALVGSGAEQSLQGLRVSKAFLSGSGLTAERGLSTSNMLSASVDRALVQAAAEVVVLADHTKLGTDTMFQTVPTDLITRLVTDEPPPHDDRAATELQALADQGVQIAVAGASGNPGGEQVPATRRAPLPGPRRGHVALRSGAGLGESAAAERGRVADLRRR
>NZ_CP013219.1|WP_058081692.1|5278426_5279569_+|GGDEF-domain-containing-protein
MGEDKRLTAVVALAQGMAAAHTPRECWQAAALGACHALDGSFAALSVWERELGRLRVLVNVGDRAPDEEEFPEAETYPVHQFPEITEFLHERWAGGGGPNAWVETAEGTAKGTPGYFHQRVAALRRRGRGCCVVAPVVLHGRAWGELYVARPVGEPLFARADADFATVLAAVVAAGIAQTERLEEARRLAYTDALTGLANRRAVDVGLEEAVERHRAEGVVVSLVVCDLNGLKRVNDTLGHAVGDRLLERFGSVLSLCGAMVPGALAARLGGDEFCLLAVGPPADDVVKAADELCRRAGELEPGEGVACGVASTEDAIGEVRDARRLFRLADAAQYRAKALRLDRPVVAGREGPDDPVVRLADAPPPSRAERRRFRGRRP
>NZ_CP013219.1|WP_058081693.1|5279657_5281196_+|histidine-ammonia-lyase
MHTVVVGTSGVTASDVLAVARGGARIELSAEAVAALAAAREIVDALAAKPDPVYGVSTGFGALATRHISQELRAQLQRNIVRSHAAGMGPRVEREVVRALMFLRLKTVCSGHTGVRPEVAQTMADVLNAGITPVVHEYGSLGCSGDLAPLSHCALTLMGEGEAEGPDGTVRPAGELLAEHGIAPVELREKEGLALLNGTDGMLGMLVMALADLDTLYKSADVTAALTLEALLGTDKVLAPELHAIRPHPGQGASAANMLAVLKGSQLTGHHQDDAPRVQDAYSVRCAPQVAGAGRDTLAHARLVAERELASAVDNPVVLPDGRVESNGNFHGAPVAYVLDFLAIAAADLGSIAERRTDRLLDKNRSHGLPPFLADDAGVDSGLMIAQYTQAALVSELKRLAVPASADSIPSSAMQEDHVSMGWSAARKLRTAVDNLTRVIAIELYAATRAIELREGLTPAPASRAVIEAVRGAGVQGPGPDRFLAPDLAAADAFVHGGDLVAAVEKVTGPLQ
>NZ_CP013219.1|WP_014674608.1|5281251_5282031_-|hypothetical-protein
MRLCATAAVSALSLALLTGCGDGGSKDSGDAKGPDAAKPAAKALSAAELKKLIIAKGDVPGYEVGPVEGGIPDRGKVTSDDAKCRPVLQAFTGIAPGEPAADTSRMATQDKKKDPTDDATSLDDLADGKFEDAINESMDLDVTVVTLASYDGDGAEQALKSVSDAVKACAGGFSGEQDGEKGTFTKVAEEKSSGTGDASVAFTATNDAGKDGALPLHAEVVRHGNTLATYTTINIGAMMSKKAYTVSAPVVKAQAAKLK
>NZ_CP013219.1|WP_014674609.1|5282091_5282418_-|hypothetical-protein
MSSARRPLLTATAAGTLLCALWFVPSANASQDAPARQTARTSAPSQVTQARAVTVATAEGADRAAEEETELADTGSFDTTPYVVGGSLFLAVGAGFVVYSVRRERLGF
>NZ_CP013219.1|WP_014674610.1|5282554_5282872_+|hypothetical-protein
MRLRVELVLEVQDDDEVAKAALRRIAADPELPEGERAQAEAAVTEDTAEALAYLVDPFDLVSEVPGVELQQASWSSERVDYDPDSPDWDLDEDDGADDEEEDGIG
>NZ_CP013219.1|WP_014674611.1|5283109_5284357_+|L,D-transpeptidase
MMTDSMRRRGLTAASALLGGVLVLTACSGGDADASGGKDTSQAKVDEAAAKKSSEAQITITPKDGSNNASINNSAAVTVRKGTLTAVTMTSQDGKTVDGRLSADKTSWKPSVQLERSTTYRLAAEAKDSDGRIAHENASFTTVSPANSFIGTFTPDDGATVGVGMPVSINFDKAITNKAAVQKGITVSSSSGQEVACHWFNANRMDCRPEEYWKEGSTVTLKLALDGVQGASGVYGVQQKTVTFHIGRNQVSYVDAQTKQMKITQDGKVVKTIPISAGSPENKTYEGQMVVSEKFKETRMNGATVGFTDDDGKGEYDIKDVPHAMRLTNSGTFIHGNYWGAPSVFGNVNTSHGCVGLQDKKGANDPSTPAAWFYSHTLIGDVVVVQHTGDKTVSPDNGLNGWNMDWAQWKAGSAV
>NZ_CP013219.1|WP_058081694.1|5284513_5285959_+|FtsX-like-permease-family-protein
MFFTYLRRELRRRRKAALVVASGLALGIALVIVVNSVSNGMGKAQDKVLQSLYGLGTDMTVTKAASASTGDAQRPRFRFDAQNNGDDATQSSDRVMVQGFQTLPASTVAEVGSQSGVSDAVGGLSLQVLKVSGQFTRGRFQQDESGGGFQRGGGTGGPQGEVKGGGADFDVNSYSVYGTDVTKPGLGPLTSSKITSGRTFKATETDAKVVVADSAYAKEKKYKTGSTVTIKGVTFTVIGIATADSGDSAANLYLPLKQAQTLADAKDKVTTVYVEAADSKKIDSVKSAIQKNVPGTTVTTSADLADTVSGSLSTASSLAADVGTWLSLAVLVAAFLVAGLLTSSAVSRRVREFGTLKALGWRSGRVTRQVVGEAMVNGLVGGALGIALGLAGAYVVTAISPGLKAQVGGGTGGGLGGGGGFPGGPGRRTAKTLEVALTAPVSVTTIVLAVGLAVAGGLIAGAFGGWRASRLRPADALRRVE
>NZ_CP013219.1|WP_014674613.1|5286081_5286765_+|ABC-transporter-ATP-binding-protein
MYELNNVTKRYTRGKDTVHALDGIDLTIPDGDRLVIQGPTGGGKSTLLQMLGGLDRPTSGEVVLDGTDLARLGEARLTRVRSESIGFVFQSFNLIPTLTAQENVETALVPLGIKVRERRELAAEALRSVGLGERLGHLPGEMSGGQQQRVAIARAVVKKPKVLLADEPTGNLDEGTRDEIMDVLERLWKEHGLTFIMVTHDSALAKKAPRLATLRKGKITVKENAAT
>NZ_CP013219.1|WP_014674614.1|5286884_5287145_-|hypothetical-protein
MLDGGLRGGGGSHRGAAGLRRRGAGHTRCEGDCCGRRHGGRSRVLHLSAQVLPLEMEYRANSPFTRSGVDSHTCPSTPRTSQYAGG
>NZ_CP013219.1|WP_058084002.1|5287106_5290313_+|S8-family-serine-peptidase
MAATAASKAAVKHHVTLITGDRVALDAKGRVVGLERAKGREHIAFQVRKASGHTLVIPADAAHLVASGTLDQRLFDITELNKAATRKAQKNGLKVIVGYRGSATAAKADVRDAGTLRRNLKALNADAVQTPVKDTAGLWDALTNGDRTASGIAHVWLDGVRKAALDKSVPQIGAPTAWAAGYTGKGVKVAVLDTGVDTSHPDLKDQVIESKNFTSAADATDHFGHGTHVASIVAGTGAKSGGKYKGVAPDAKLLNGKVLDDNGFGDDSGILAGMEWAASQGADVINLSLGGYDTPEIDPLEAEVNKLSAEKGVLFAIAAGNEGPQSIGSPGSADAALTVGAVDDKDQLADFSSTGPRAGDGAIKPDVTAPGVDITAAAAKGSVIDQEVGEKPEGYLTISGTSMATPHVAGAAAILKQEHPDWGYADLKGALTGSTKGGKYTPFQQGSGRIQVDKAIKQSIVADPVSVSFGVQQWPHTDDKPVTKKLTYRNLGDKDVTLTLSSTATNPKGAAAPSGFFKLGTTTLTVPAHGTASADFTVDTKLGGTVDGAYSAYVTATGDGQTVRTAAAVQREVESYDLTLKFIGRDGKPAPYYEADVSGVAGLANGVSLNPYDKSGTVKVRAPKGTYILNTSVYGDPQDASKGIDWIAQPKLTVDKKQTITIDARKAKPVDITVPASGVKSAFASPEYDVTIGNGQYGYGWFLDSYKNFRSAHLGPQLPAGTLWQQWDGHWTKGATEEYDVTTGGAVKQLATGYTKHYKAGELATVKARLGAAASGKKGSIDAVGWLPGSSGASSISIPQKLPGTRTLHLSATGGVKWELQFEQDGGVDQDGFPVAEAGYGLGQFTFKGGQTYTKTVNTAVFGPHLGKEFGLFRDGNEIFGALPLFADSAKHAGSSLFTSVNTTLYRNGTKVGSNTDPLFGEATFKVPSGDAAYKLTTSVKRSAKVSEASTRIDAAWTFRSKKPADFAKLPASAPHFGATTGLDSRVTAGKTVTFPVTVEGSAAGGNLKSLAVYVSYDGKNFKKVTVKNGKITVKNPAKNKAISFRANITDKKGNTSAITIYNAYFGK

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Crispr_ID: NZ_CP013219_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013219_10

5340446-5340531

Orphan

Consensus_repeat	Method
CGGGTCCGTCACCGACGTGAGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013219_10

>merge|NZ_CP013219|10|5340446-5340531|CRISPRCasFinder
CGGGTCCGTCACCGACGTGAGGTGGCCGGCCTCGTCGTACGTGAAGCGGGTCGTCTGGCCCGCCGGGTCCGTCACCGACGTGCGGT

>NZ_CP013219|10|8|5340446-5340531|CRISPRCasFinder
CGGGTCCGTCACCGACGTGAGGT	GGCCGGCCTCGTCGTACGTGAAGCGGGTCGTCTGGCCCGC
CGGGTCCGTCACCGACGTGCGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013219.1\|WP_058081713.1\|5329379_5330417_+\|sugar-kinase	unknown	unknown	gnl\|CDD\|238571
NZ_CP013219.1\|WP_058081718.1\|5334595_5335447_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP013219.1\|WP_014674656.1\|5331174_5331585_+\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100004
NZ_CP013219.1\|WP_079088261.1\|5337204_5337495_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058081720.1\|5336101_5336593_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058081714.1\|5330413_5331178_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP013219.1\|WP_058081725.1\|5346158_5347049_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058081715.1\|5331710_5333189_+\|permease	unknown	unknown	gnl\|CDD\|308194
NZ_CP013219.1\|WP_058081717.1\|5334395_5334593_-\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP013219.1\|WP_058081727.1\|5349064_5349445_+\|pilus-assembly-protein	unknown	unknown	gnl\|CDD\|377921
NZ_CP013219.1\|WP_014674672.1\|5349806_5351144_+\|CpaF-family-protein	unknown	unknown	gnl\|CDD\|227297
NZ_CP013219.1\|WP_058084006.1\|5343515_5344040_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_159103830.1\|5337673_5338105_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058081728.1\|5349446_5349788_+\|septum-formation-initiator	unknown	unknown	gnl\|CDD\|377921
NZ_CP013219.1\|WP_058081726.1\|5347821_5349057_+\|MinD/ParA-family-protein	unknown	unknown	gnl\|CDD\|349765
NZ_CP013219.1\|WP_058081716.1\|5333322_5333868_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058081723.1\|5342868_5343519_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058081724.1\|5344161_5345880_-\|chitinase	unknown	unknown	gnl\|CDD\|119350
NZ_CP013219.1\|WP_079088077.1\|5345904_5346129_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_014674668.1\|5347107_5347812_+\|Flp-pilus-assembly-protein-CpaB	unknown	unknown	gnl\|CDD\|379909

Protein	Function_ID	Function_description	E-value
NZ_CP013219.1\|WP_058081713.1\|5329379_5330417_+\|sugar-kinase	gnl\|CDD\|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	5.39705e-85
NZ_CP013219.1\|WP_058081718.1\|5334595_5335447_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	6.67423e-08
NZ_CP013219.1\|WP_014674656.1\|5331174_5331585_+\|RidA-family-protein	gnl\|CDD\|100004	cd00448, YjgF_YER057c_UK114_family, YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	6.72668e-34
NZ_CP013219.1\|WP_014674668.1\|5347107_5347812_+\|Flp-pilus-assembly-protein-CpaB	gnl\|CDD\|379909	pfam16976, RcpC, Flp pilus assembly protein RcpC/CpaB. RcpC is a family of Gram-negative proteins expressed from the tight-adherence tad locus. RcpC is an auxillary protein that sits in the inner membrane and interacts with TadB and TadZ, an AAA ATPase. A recent study has identified two tandem beta-clip domains in RcpC95. beta-Clip domains are known to interact with carbohydrate moieties in other systems, such as SAF.	1.43459e-20
NZ_CP013219.1\|WP_058081715.1\|5331710_5333189_+\|permease	gnl\|CDD\|308194	pfam02447, GntP_permease, GntP family permease. This is a family of integral membrane permeases that are involved in gluconate uptake. E. coli contains several members of this family including GntU, a low affinity transporter, and GntT, a high affinity transporter.	6.82595e-127
NZ_CP013219.1\|WP_058081717.1\|5334395_5334593_-\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	4.0771e-17
NZ_CP013219.1\|WP_058081727.1\|5349064_5349445_+\|pilus-assembly-protein	gnl\|CDD\|377921	pfam07811, TadE, TadE-like protein. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in question is this family has a high proportion of hydrophobic amino acid residues.	0.00299778
NZ_CP013219.1\|WP_014674672.1\|5349806_5351144_+\|CpaF-family-protein	gnl\|CDD\|227297	COG4962, CpaF, Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion].	2.24615e-136
NZ_CP013219.1\|WP_058081728.1\|5349446_5349788_+\|septum-formation-initiator	gnl\|CDD\|377921	pfam07811, TadE, TadE-like protein. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in question is this family has a high proportion of hydrophobic amino acid residues.	7.3925e-05
NZ_CP013219.1\|WP_058081724.1\|5344161_5345880_-\|chitinase	gnl\|CDD\|119350	cd02871, GH18_chitinase_D-like, GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (GH18) domain, a chitin-binding domain, and a fibronectin type III domain. The chitin-binding and fibronectin type III domains are located either N-terminal or C-terminal to the catalytic domain. This family includes exochitinase Chi36 from Bacillus cereus.	1.97627e-115
NZ_CP013219.1\|WP_058081726.1\|5347821_5349057_+\|MinD/ParA-family-protein	gnl\|CDD\|349765	cd03111, CpaE-like, pilus assembly ATPase CpaE. This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains 7 genes: pilA, cpaA, cpaB, cpaC, cpaD, cpaE and cpaF. These genes are clustered together on chromosome.	3.23031e-37
NZ_CP013219.1\|WP_058081714.1\|5330413_5331178_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	8.83188e-72

>NZ_CP013219.1|WP_159103830.1|5337673_5338105_-|hypothetical-protein
MTPNDEIKRQFEGAGFEVIGRFPESEPSVTKAFNRVMNVSAKPIERIPRNEPDIAEKVNTAWAAHARNAGVLADDGSFLAAGSLEYGWLQLRLTSASNIYSLRQPDGDLLFIARSLSGHRVCAVSREESEYWILEEQFLPDGY
>NZ_CP013219.1|WP_079088261.1|5337204_5337495_-|hypothetical-protein
MEHWKVGWAHEFQSEPVRSYSEIGSDRYDARKIQIYRDERILKADTSHESAEIGLREVPAGSIDDVANQPDFSASSISPEGFEQAWRTASWATRRQ
>NZ_CP013219.1|WP_058081720.1|5336101_5336593_+|hypothetical-protein
MPFIRRGLTMTTSLLALTGFIGTGAAAHAAQTDDGNGYRPCVITIQGNHNENSYQSCGQILTGTGHVTGANHTIGSGAPGRSNSLPQVGVTPTNLLSAPQDNADVVAFLPGGTDVSAACTVKSPAGDGIFYLVVTNVNNYPTAGWVPAESVQTTADFPACLPD
>NZ_CP013219.1|WP_058081718.1|5334595_5335447_-|helix-turn-helix-domain-containing-protein
MPRRQQPTARQERLGAELRKLREAAGLKGREAAALLGTDAAQMSQIEAGTAGVSEERVRRLAAQYSCTDAALINALVAMATDRTHGWWEEYRGRLPTPFMDLPELEHHASHRWDVEFLHIPGLLQTPEYARALFAYVNPEFPESDVERWVEHRMKRRVIIERPDPVPYEALVHEAALRIRVGDRSAARTQLVRVLELSEADHVTVRVIPFDLDDFGGAGSAMVYAGGPVPRLDTVVRDGPGGPVFIDAEAQLSRYRTLFRRVEAASLDPGRSRDLIHRLAKEL
>NZ_CP013219.1|WP_058081717.1|5334395_5334593_-|DUF397-domain-containing-protein
MLTPDTWQKSSFSGGGQGDACVEVCDRRTHISVRDSKAPIRATLTFPARAFTPFIEALKARHPAG
>NZ_CP013219.1|WP_058081716.1|5333322_5333868_+|hypothetical-protein
MKAESVKAEPVKVEPVMGAGFDPAFVPGITGPTPTDGVAKSPEPKGAQEPPSAEPASPERVDAEEAGAEAVADADAEDVADADAEDKADGPVFEASDRRARIVADRKGVRLSLDEEACEFRWDEIAAVETESPRFGKRYTITVHTPDRRWYPIEIEAAARARFKEWDEQIDAVLDAYFEEA
>NZ_CP013219.1|WP_058081715.1|5331710_5333189_+|permease
MSYPFAAPAPAAPPHTGGLLLLVDGTAGLLTVAAVGIALLLFLIIKVRLQPFVALLAVSIAVGLLAGLSVTELFGTVQRSDAVSTIESGMGGILGHVAIIIGLGTMLGAVLEVSGGAEVLASRLLALFGERRAPLAMGLTGLIFGIPVFFDVGIFVLAPIVYAAAKRSGRSILLYCLPLLAGLSMTHAFLPPHPGPVAAAGLLHVDLGWVILMGVVCGIPAVLAAWAYSAWIGRRVFVAVPQDMVEAAAEAKQAVLQEQRASGVEPREEPVPLGTVLAIIGTPLVLILAATFSSIAFDPSTGRSVVEFFGDPFVALTIALLLAYYLLGIRRGWSRKSLETVSTASLKPIGNILLVVGAGGVFGAVLKASGVAQALSDTFHDVGLPVIVLSYLISVVLRVAQGSATVAIVTTAGIVAPLLSEGQHSQAFVALVIMAISAGSIFASHVNDGGFWMVAKYFGISERDTLRTWTVLESVLSLAGFAVAAVVSVFVS
>NZ_CP013219.1|WP_014674656.1|5331174_5331585_+|RidA-family-protein
MTDKIALTPKTHTTPPAKFSHGVRKGNILQVAGQVGFLPAEEGKPPTPAGPSLREQTLQTLANVKAILEEGGAGWDDVMMIRVYLTDVGHFAEMNEIYNAYFEEQGLTQPPAARTTVYVGLPAGLLIEIDALAVLG
>NZ_CP013219.1|WP_058081714.1|5330413_5331178_+|IclR-family-transcriptional-regulator
MSQTVDRALSILPLLAEGPADLGQVADRLGVHKSTALRLLRTLHEHGLVYRQSDQRYRLGARLFALAQEAMENLDIREIAHPHLVRLNEQCGHTVHLAVYEENEVLYIDKVESRYPVRMYSRIGKPVAITVAAVAKLLLADLPEPERRALAQQLDYPLYTARSTPHAEAFLKELATVREQGWATDLGGHEESINCVAAPIRGADGRVVAAMSVSAPNVVVTAEELLTLLPLVRRTADAISGEYSGRTPVKDRTA
>NZ_CP013219.1|WP_058081713.1|5329379_5330417_+|sugar-kinase
MDVDVVALGESMVTFLPSRPGRLADVPSFDRAIGGAESNVACALAAFGHTARWVSRVGADGFGDHLLERIAGYGVDVTAVHRDPGRPTGVYFRTAGDRGTGAHEVAYYRAGSAASAMSPGNVDLTAARSARVLHLTGITAALSDECRELLHELTAPAPGRPLISFDVNYRPGLWGDGEGAHVLLELARRADIVFVGADEARDAWGLHGGASIVEALPQPDIVVVKQGKGGATAFARGTDGTEDAGGTATRVRAPGVDVVAHVGAGDAFAAGFLSATLRGLTVRDRLRYGHLFAAAALTTPGDLAAPPARGHADRLAALDDDAWGRLRLGPGWTQAEQAEEEANIP
>NZ_CP013219.1|WP_058081723.1|5342868_5343519_-|hypothetical-protein
MTGGGGEDLVAQGLGLIAKGLTEALGELKELGMVGEAGAGRGFSDIALSGLELGHEGLTDDFASFCERWEWGVRSLIHEGNGFAVKTGLAAGMYYETDQYVKGSFKIVANAAVGNPYASEEDVQKMGYGEIASSVGDVDYSKESFEQAWETGKHGWKDAGRDLMTSHTVGAMGLGPEDLHQAFGVSDKEYDQYLDDTFGPSPEARAKAAEQQGGEG
>NZ_CP013219.1|WP_058084006.1|5343515_5344040_-|hypothetical-protein
MIPSMVEDGRRTRRSRLYDYTDTVVPGPSGTTDDPERGRRQFAALLGEFRRTAVLVPLDPETGSPLTADFGGVRWFYVFSNEGALARFALARGEGEREWPYQRWLGARLLDAAVPAVGVPCGVALDCADGEDGMVFPPVRGIVPDAVAVDAGTEAEDTQDTQDTQDTQDMGDGR
>NZ_CP013219.1|WP_058081724.1|5344161_5345880_-|chitinase
MDRVPGIPRPRGRRLAAWSAATALALSVAGLATAGPASAADVNNVKNAGFESGLANWTCTAGSGTTVTSPAHGGTAALKATPAGQDNAQCSQTVAVKPNSTYTLSAWVQGGYSYLGVTGTGTTDVSTWTPDSASWKQLSTTFTTGSSTTSVTVYTHGWYGQAAYYADDLSVYGPDGGGGGDPAPTVPAAPAGLSVTGTTSSAVSLSWSAVSGATGYNVYRNGTKVTAVTGTSATVTGLTAATSYSFQVTATNAAGESARSATVTGTTASGTGGGGGGSLPKHAVTGYWQNFNNGATVQKLSDVPSSYDIIAVAFADATSTPGAVSFTLDSAGLNGYTVDQFKADIKAKQAAGKKVIISVGGEKGSVSVNDASSAANFANSVYSLMQTYGFDGVDIDLENGLNATYMTQALRALSSKAGSSLIITMAPQTIDMQSTSNTYFQTALNIKDILTVVNTQYYNSGSMLGCDGKVYSQGTVDFLTALACIQLEGGLSPSQVGLGVPASTRAAGSGYVSPTVVDNALDCLTAATNCGTFKPSKTYPALRGAMTWSTNWDAASNNAWSNTVGPHVHALP
>NZ_CP013219.1|WP_079088077.1|5345904_5346129_+|hypothetical-protein
MRGGEGGEGRWPPLAPKLVQTNPGVKRSRPKPAPLGDSTCPGLAGLDPGEFHTGFTNAVLRPYARGYSAQVVTQ
>NZ_CP013219.1|WP_058081725.1|5346158_5347049_+|hypothetical-protein
MGRAGVKSGELRVPTAIAVTSADMALPAQDERTMPAVVLTGLDHKPLDQALTELNALTEQYGYVVVVCSQATPEPVVRRLHTLRSLLESDRIALFRPELPPLGIAVLARQLRQLASCDLSPGVLASAGRLLTHYIHAGAVLGSVAKLDRVPVGLKAHARSWMPGSQFAVLAHPEPQLVKVAPDATLKGPDFSTWMLVAKGQSQSDWAAGLGTRWGVHGLREVPLPAESPVWWGTGRLVEFCGYLADLSVLYQLVTSVRQTSCHWCGLDVIGDRCVFCSATSPAYETPRALEQRTPA
>NZ_CP013219.1|WP_014674668.1|5347107_5347812_+|Flp-pilus-assembly-protein-CpaB
MNSRQRRGVILLILSVLCALGAFAGVLSVIHDANSKVGPEVAAYRVRSEVKPYTALDTGQFEKIEMPKRWLSGNAVTDLRQIRGKIAVTTLRAGSLLQTDMIVDRPALQPGQQEVAIMIDAATGVAGKITPGSRVNVYATFEGKKEGDPDQSKIIVTNARVIDVGRITALEPDRDKDRQPTEAVPITFALSTIDAQRVTYAESFAQRVRLALVAPGSETSVPDKDRTYELATDK
>NZ_CP013219.1|WP_058081726.1|5347821_5349057_+|MinD/ParA-family-protein
MPTRILPAGADPDAVRSLTTLLSQLPDAEPQPPVTDSTQLVDALARLAAESVDELPEVVVVHERIGPVPALELIREVALRFPAVGVILVTTDTSPGLFAAAMDSGARGLVALPLSYEELANRVQAVAQWSTGVRRHLGHGAEALAGAGGTVVTVSGAKGGVGTTLTAIQLALAAQASGRATALVDLDLQTGDVASYLDIQFRRSVADLAAITDISPRVLADAVFRHDTGLALLLAPGEGERGEEVTDRATRQLVSALRSRYEVVVVDCGAQLSGAGAAAVEMADTALLVTTPDVIAVRAAKRTVRMWDRLQIRKAEETTVVVNRHTRSTEIQPALVQRITGTALARTAVPANFKELQGVVDAGRVHELDARSTVKQALWGLAGELGLVKAAEGASHRGSGRGSVSLRRRKE
>NZ_CP013219.1|WP_058081727.1|5349064_5349445_+|pilus-assembly-protein
MRRPDGDRGQVSVEFLGMTPLIVLTLVLMWQAVLVGYTFTLAGNAADEAVRAGTAAPRGGARQAACAEAGMEHLSGAWKGDASVQCSASGYVTADVSLKVPVLFPGVISFPATVHGHAGAVEEVKD
>NZ_CP013219.1|WP_058081728.1|5349446_5349788_+|septum-formation-initiator
MPYRPGRDRGQVAIEYLGFIPVLLIVGLAGIQLGAVAYAAEQAGTAARAGARAASLDQSYAQACADAVSGGLKVSCSSAPGGDSVTVTATVHIPAIVWDLGSATKSATMPLDH
>NZ_CP013219.1|WP_014674672.1|5349806_5351144_+|CpaF-family-protein
MSLRARISTPEEHGSRGEDGHLVASYRAKLLEEIDLAEMSALAAAERRARLERVLGHIISREGPVLSTVERSQLIRRVVDEALGLGILEPLLEDASITEIMVNGPDAIFVERGGRVEQLPLRFVSADQLMQTIERIVSTVNRRVDESNPMVDARLPSGERVNVIIPPLSLTGPVLTIRRFPRSFTLQELIGLGSLDEHMVYLLAGLVQAKFNIIVSGATGTGKTTLLNALSGLIPAHERIITIEDSAELQLQQTHVVRLESRPPNVEGKGQVTIRDLVRNSLRMRPDRIVVGEVRGGESLDMLQAMSTGHDGSLATVHANSAEDALTRLQTLASMSDVEVPFVALHDQINSAVDVIVQLTRFADGARRITEIALLDSHGGEPYRLATVARFDARPMTPDGRVYGDFRYFPLPRRTADRLYMASQPVPQAFGVARSADQLATREAR

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Crispr_ID: NZ_CP013219_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013219_11

6102481-6102577

Orphan

Consensus_repeat	Method
GGCTGTCTGCCGTGGAGCGGCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013219_11

>merge|NZ_CP013219|11|6102481-6102577|CRISPRCasFinder
GGCTGTCCGCCGTGGAGTGGCTGTCTGCCGTGGAGCGGCGCCCCGCCGTGAAGTGGCTTTTCCCCCGTGGGCCGGCTGTCTGCCGTGGAGCGGCGGC

>NZ_CP013219|11|9|6102481-6102577|CRISPRCasFinder
GGCTGTCCGCCGTGGAGTGGCTGT	CTGCCGTGGAGCGGCGCCCCGCCGTGAAGTGGCTTTTCCCCCGTGGGCC
GGCTGTCTGCCGTGGAGCGGCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013219.1\|WP_058082102.1\|6097402_6100477_+\|translation-initiation-factor-IF-2	unknown	unknown	gnl\|CDD\|235401
NZ_CP013219.1\|WP_159103880.1\|6108097_6111610_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223531
NZ_CP013219.1\|WP_058082110.1\|6115798_6117064_+\|type-VII-secretion-associated-serine-protease-mycosin	unknown	unknown	gnl\|CDD\|274856
NZ_CP013219.1\|WP_058082103.1\|6101461_6102367_+\|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl\|CDD\|235113
NZ_CP013219.1\|WP_159103834.1\|6118392_6118704_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_014675351.1\|6101006_6101465_+\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|234787
NZ_CP013219.1\|WP_014675347.1\|6095319_6095847_+\|ribosome-maturation-factor-RimP	unknown	unknown	gnl\|CDD\|234627
NZ_CP013219.1\|WP_078611825.1\|6096960_6097257_+\|YlxR-family-protein	unknown	unknown	gnl\|CDD\|225350
NZ_CP013219.1\|WP_079088270.1\|6102932_6106925_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237057
NZ_CP013219.1\|WP_058082109.1\|6114250_6115774_+\|type-VII-secretion-protein-EccB	unknown	unknown	gnl\|CDD\|368288
NZ_CP013219.1\|WP_058082100.1\|6094090_6094591_-\|ferritin-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|373114
NZ_CP013219.1\|WP_058082101.1\|6094587_6095088_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_014675350.1\|6100672_6100966_+\|DUF503-domain-containing-protein	unknown	unknown	gnl\|CDD\|377364
NZ_CP013219.1\|WP_159103833.1\|6117658_6118357_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058082108.1\|6112681_6114043_-\|type-VII-secretion-protein-EccE	unknown	unknown	gnl\|CDD\|274857
NZ_CP013219.1\|WP_058082107.1\|6111932_6112682_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058082111.1\|6117173_6117527_-\|DUF4333-domain-containing-protein	unknown	unknown	gnl\|CDD\|379513
NZ_CP013219.1\|WP_079088269.1\|6095044_6095323_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_014675348.1\|6095849_6096836_+\|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl\|CDD\|237061
NZ_CP013219.1\|WP_058082105.1\|6107055_6108003_+\|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl\|CDD\|235536

Protein	Function_ID	Function_description	E-value
NZ_CP013219.1\|WP_058082105.1\|6107055_6108003_+\|bifunctional-riboflavin-kinase/FAD-synthetase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	1.86522e-148
NZ_CP013219.1\|WP_159103880.1\|6108097_6111610_-\|AAA-family-ATPase	gnl\|CDD\|223531	COG0455, flhG, Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility].	2.16611e-49
NZ_CP013219.1\|WP_058082110.1\|6115798_6117064_+\|type-VII-secretion-associated-serine-protease-mycosin	gnl\|CDD\|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	2.9254e-95
NZ_CP013219.1\|WP_058082103.1\|6101461_6102367_+\|tRNA-pseudouridine(55)-synthase-TruB	gnl\|CDD\|235113	PRK03287, truB, tRNA pseudouridine synthase B; Provisional.	1.54593e-163
NZ_CP013219.1\|WP_058082102.1\|6097402_6100477_+\|translation-initiation-factor-IF-2	gnl\|CDD\|235401	PRK05306, infB, translation initiation factor IF-2; Validated.	0
NZ_CP013219.1\|WP_014675347.1\|6095319_6095847_+\|ribosome-maturation-factor-RimP	gnl\|CDD\|234627	PRK00092, PRK00092, ribosome maturation protein RimP; Reviewed.	1.42223e-43
NZ_CP013219.1\|WP_078611825.1\|6096960_6097257_+\|YlxR-family-protein	gnl\|CDD\|225350	COG2740, COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription].	2.67521e-25
NZ_CP013219.1\|WP_079088270.1\|6102932_6106925_+\|hypothetical-protein	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	4.64982e-07
NZ_CP013219.1\|WP_058082109.1\|6114250_6115774_+\|type-VII-secretion-protein-EccB	gnl\|CDD\|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	8.67323e-60
NZ_CP013219.1\|WP_058082100.1\|6094090_6094591_-\|ferritin-like-domain-containing-protein	gnl\|CDD\|373114	pfam14530, DUF4439, Domain of unknown function (DUF4439). This domain has a ferritin-like fold.	1.05363e-30
NZ_CP013219.1\|WP_058082111.1\|6117173_6117527_-\|DUF4333-domain-containing-protein	gnl\|CDD\|379513	pfam14230, DUF4333, Domain of unknown function (DUF4333). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 140 and 255 amino acids in length. There are two completely conserved C residues that may be functionally important.	4.73365e-15
NZ_CP013219.1\|WP_014675350.1\|6100672_6100966_+\|DUF503-domain-containing-protein	gnl\|CDD\|377364	pfam04456, DUF503, Protein of unknown function (DUF503). Family of hypothetical bacterial proteins.	9.03361e-36
NZ_CP013219.1\|WP_058082108.1\|6112681_6114043_-\|type-VII-secretion-protein-EccE	gnl\|CDD\|274857	TIGR03923, T7SS_EccE, type VII secretion protein EccE. This model represents the transmembrane protein EccB of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccE1, EccE2, etc. This model represents a conserved core region, and many members have 200 or more additional C-terminal residues. [Protein fate, Protein and peptide secretion and trafficking].	7.75093e-48
NZ_CP013219.1\|WP_014675351.1\|6101006_6101465_+\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	7.95904e-50
NZ_CP013219.1\|WP_014675348.1\|6095849_6096836_+\|transcription-termination/antitermination-protein-NusA	gnl\|CDD\|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	0

>NZ_CP013219.1|WP_058082103.1|6101461_6102367_+|tRNA-pseudouridine(55)-synthase-TruB
MTQKHTTPDGLVIVDKPSGFTSHDVVAKMRGIARTRRVGHAGTLDPMATGVLVLGVERATKLLGHLALTEKEYLGTVRLGQNTLTDDAEGEITSSADASKVTRDAIDAGIAKLTGDIMQVPSKVSAIKIDGVRSYKRAREGEDFEIPARPVTISSFTVYDVRDAVAEDGTPVLDLVVSVVCSSGTYIRALARDLGADLGVGGHLTALRRTRVGPYKLDAAKTLDQLQQELTVMPIAEAATAAFPRWEVDGRRSRLLLNGVRLEIPDEYAGGGPVAVFDTEGRFLALVEEHRGKAKSLAVFG
>NZ_CP013219.1|WP_014675351.1|6101006_6101465_+|30S-ribosome-binding-factor-RbfA
MADNARAKRLADLIREVVAQKLQRGIKDPRLGSHVTITDTRVTGDLREATVFYTVYGDEEERKAAAAGLESAKGILRSEVGRAAGVKFTPTLTFVADALPDTARTIEDLLDKARQSDEKVREAATGATYAGGADPYRKPADDDSDTDGDATE
>NZ_CP013219.1|WP_014675350.1|6100672_6100966_+|DUF503-domain-containing-protein
MYVGTLSFDLLLGDVHSLKEKRSVVRPIVAELQRKYAVSAAEVDHMNLHRRAVIGLAAVSGDAAHLTDVLDRCERLVAGRPEVELLSVRRRFHGDDD
>NZ_CP013219.1|WP_058082102.1|6097402_6100477_+|translation-initiation-factor-IF-2
MAKVRVYELAKEFGVESKVVMAKLQELGEFVRSASSTIEAPVVRKLTDAFQGGGNGKSAGKPAPRKAAPRPAAPSPAQAARPAAPAPRPAAPKPPTAPAAQQPAAPSAPSAPAQAPAPGPRPVPGPKPAPRPAPAAPEFTAPPAPAAQTPQAPAAQGPRPGARPGAPKPGGARPAPGQGQGQGARPGQGGARPGGQAARPGARPAGPRPGNNPFTSGGNAGMARPQAPRPQGGPRPGPGGAPGAGPRPQAPGAQGGGPRPQAPGGNRPSPAGMPRPQGGPRPGPAGPRPNPGMMPQRPAAGPRPGPGGGRGPAGAGRPGGGGRPGGGGFAGRPGGGGGARPGGGGGFAGRPGGGGGFGGGPGGGGGGRPGFGGRPGGPGGRGGTQGAFGRPGGPARRGRKSKRQRRQEYEAMQAPSVGGVMLPRGNGETIRLSRGASLTDFAEKINANPASLVAVMMNLGEMVTATQSVSDETLQLLADEMNYTVQIVSPEEEDRELLESFDIEFGEDEGSDEDLVVRPPVVTVMGHVDHGKTRLLDAIRKTNVIAGEAGGITQHIGAYQVATEVNDEERKITFIDTPGHEAFTAMRARGAKSTDIAILVVAANDGVMPQTVEALNHAKAADVPIVVAVNKIDVEGADPTKVRGQLTEYGLVAEEYGGDTMFVDISAKQGLHIDSLLEAVILTADASLDLRANPNQDAQGISIESRLDRGRGAVATVLVQRGTLRVGDTMVVGDAYGRVRAMLDDNGNNVAEAGPSTPVQVLGLTNVPGAGDNFLVVEEDRTARQIAEKRAARERNAAFAKRTRRVSLEDLDKVLKAGEVQQLNLIIKGDASGSVEALESSLLQLDVGEEVDIRVLHRGVGAVTESDIDLAMGSDAIVIGFNVRAAGRAAQMAEREGVDVRYYSVIYQAIEEIEAALKGMLKPEYEEVELGTAEIREVFRSSKLGNIAGVLIRSGEVRRNTKARLIRDGKVIAENLNIEGLRRFKDDVTEIREGYEGGINLGNFNDIKVDDVIATYEMREKPRV
>NZ_CP013219.1|WP_078611825.1|6096960_6097257_+|YlxR-family-protein
MSGRTHARACPERTCVGCRERAAKNDLLRIVKIEDACVPDPRGTLPGRGAYVHPALVCLDQAVRRRAFPRALRVPGPLDTKALRRYVEQTTVAEQATP
>NZ_CP013219.1|WP_014675348.1|6095849_6096836_+|transcription-termination/antitermination-protein-NusA
MDIDMSALRGLVREKEISFDLLVEAIESALLIAYHRTEGSRRHARVELNRETGHVTVWAKEDPEDLAEGQEPREFDDTPSGFGRIAATTAKQVILQRLRDAEDDATLGEYAGREGDIVTGVVQQGRDPKNVLVDIGKLEAILPVQEQVPGESYSHGMRLRSYVVRVAKGVRGPSVTLSRTHPNLVKKLFALEVPEIADGSVEIAAIAREAGHRTKIAVRSTRSGLNAKGACIGPMGGRVRNVMGELNGEKIDIVDWSDDPAEMVANALSPARVSKVEVVDLASRSARVTVPDYQLSLAIGKEGQNARLAARLTGWRIDIRPDTEQAGE
>NZ_CP013219.1|WP_014675347.1|6095319_6095847_+|ribosome-maturation-factor-RimP
MSTTQSERLRELLEPLVTSQGLDLEEIAVDSVGRKRVLRVVVDSDAGADLDAIADVSRALSAKLDETNAMGDAAYDLEVGTPGAERLLTEHRHFVRATDRLVKFQLTEGGELVARILKVDDEGVDVEVPGVKGRKATARRLGFPEIAKARVQVEFNRKDSAGTAGEKDMKEEEEA
>NZ_CP013219.1|WP_079088269.1|6095044_6095323_+|hypothetical-protein
MRGPEGTREGGGYGTADVLGGSYEHTGGNAGPPLITVPASPSAPRHRLGGRPHPAADHPGPSMRTGPRRRQYPLIRHATHPTTAHAAEESPG
>NZ_CP013219.1|WP_058082101.1|6094587_6095088_-|hypothetical-protein
MPYPPPSRVPSGPRRRTLLVSAAGGALLTGCSAGPESGDDGPSATQRARARAARDSRGLLARYDAVLAAHPGLADRLRPLRAQVAAHAAAFTDGTAPTASATATASAVPVPAGEKDAVAGLAAAERALADRRAKDLLEAPGELARLLASVAAAGAAHAYLLTEGAR
>NZ_CP013219.1|WP_058082100.1|6094090_6094591_-|ferritin-like-domain-containing-protein
MSDGTEQAGTAELTALQAALAAEHAAVYGYGVVGGRIGERRRAEARSAYDAHRARRDALVRAVRDLGGAPVAASAAYALPFPVEDGAGALRLAARLEERVAGVYSDLVRATTGARRADAAGALREAAVRAVRWSGGSVAFPGLAERSGERTGAAGTAPSPSGSPPR
>NZ_CP013219.1|WP_079088270.1|6102932_6106925_+|hypothetical-protein
MGEDCAAGGPGEGPAHRALATTPADVAGAGAGTGRCAAALVRIRDLAGRPRGLGFLADHEGTLLTSHEAVDGLPRLVLHADGDRTCVVGPDAITALPGLDLALVRTGGLGVEPLPLTVRERIDAGTYVQVAAGCWREARVLAATQVTYTATDRFHLLDDALELAIGTAGRDALRLGGGAAGGPVLDARTGAVVGVLGTALHSAQRDAGFAVPLRPVDGALADLLARNAATVPAYGADLNLAGILQLTMTSVGQDGPPGAVEPVERAGIAGELTAFATGDRPALGLVGAPGSGRTTELAALAARRARGERPAPTLWLRGAGLRGTDASVADVARRALTRAARIIAASRSGRPEDLGDITPERVARLAARAGRPLLLLLDCPEEMPPALADRLSAWAQGTATWLTETGTRLVVACREEHWERTGRAFPPAALHVPGDPGEPVRTPPDDRVPAGGGEPSATESGAGAPTSDPGPDRAPADSAARADGAGAVYASAGSAVEAGGAGAVYAAAGSAAPAGGGEPLHSAPADPASSPDDAEPRVPLPRLALPAGSPDPHHPPARLASPADSPVPDPTPGTPVTPAQASPAPAEPVPGVPGVPGEAPLTPATDPLPPCLRVGDFTVGEARWARVRYGIPEGALGERDARHPLVLRLLSEVRAAVPDAPVVGPLDRHDVFAAYLDLMCLRIAVRLAAAGGLRGTAVRRLAARVAGQVHEAARRSLGPGQGELDGESFEAVFPWGPAPARLGGGTGWASAVLSEGLLVPAGTGYRFAHEELADWIQGMHLDLDAALLALVHRVGEPSAPRPVPYHRVGPVVQALLLLARQQGTGQLALRLRELVDALDRDTGSWWAARLLARTLLQVPDATPYTEVLRLLADRVVAWHGARRPVPADFRPAFWTGLPVPDTERLDLLRRLVLADPAPPAAGDRYLDAVAGLLTAAPTAVQPLLTRWFTDERPLPATPHATVATAAQALLHTHRHGALDDLTEVLVACSHRRADELLAVLAEEEPSALCRAVDRWAHDERPARRVAAVAFALRAAPHARSDADRELLRYAALTLLARPADRTLHGAALALLVRDPRSRDRHLPAALRHFTDGDPQFPPSALVPALTTHPEPVLEAFRVRLCAPGAGGPETGAVLRGLTQVGTPALARRVAALVQEALRLRPETAGPVAGQVAGQVGRRLEQGPTARPVLLPLVTGLLDGAPEPLRAALATVLAAPGTPASRPFRRELLEFLLAREEEPSVLLAVLHAATEHGGREEEARGLVHRTGLLLVRTPEGATRFDRALVDIGRHVPGFAARMARWLNETPDDWAAVVGPSARRMIESLAGVRVPA
>NZ_CP013219.1|WP_058082105.1|6107055_6108003_+|bifunctional-riboflavin-kinase/FAD-synthetase
MQRWRGLEDIPEDWGRSVVTIGSYDGVHRGHQLIIKHAVDRARELGVPAVVVTFDPHPSEVVRPGSHPPLLAPHHRRAELMTELGVDACLILPFTTEFSKLSPADFVVKVLVDKLHAKAVVEGPNFRFGHKAAGNVDFLIEQGRIYDFEVEVVDLYVTGEAGGGEPFSSTLTRRLVAEGDVAGAREILGRPHRVEGVVVRGAQRGRELGFPTANVETLPHTAIPADGVYAGYLHAQGEAMPAAISVGTNPQFDGTERTVEAYAIDRVGLDLYGLHVAVDFLAYVRGQAKFESLDALLEQMTADVKRCREIVAAEE
>NZ_CP013219.1|WP_159103880.1|6108097_6111610_-|AAA-family-ATPase
MRGGWDTPGDDQPDAEAVETTGEFTIDYAPPAWYTQNASGAGGTGAGGTGGAGGFAGSAGSAAAGDSGTPAAPGLPFPNTAPVPGPTPPPPATPPVGTPPQGTPFIPAQGPSYGPAEGTPYGPAQGASFTPPQGTAYAPPAGPAQPAPPTGDPVPMPRLPEGFEPQQAQPARPEASAASGAVEPETDNGDLESGATMRFSAVALKRQMAEIAERAGASGEPAESGDGGSGGAEGSADAEGSGGSEGSPGASGAEGSVDSEGDVDRAGTSGGEDGPEESGGEAAAQDGSVAEATVSGGCASDATAADEKTASDESDESDESDGSVAEQAPADKGDAEKDGADGGAVGAVRPAGADGSADSAQSDGPKPSDVGAASVTAEAGAPQPGAADDSALPGDGAADSGASDSAAQHADAAHPGTPESGAPQAHTPHPAPGQPGGYGFPQPDAAHPGAQPHAAQPAPGAPYGAVPPAPPAPQGAQPGWTPPAPQNGLPPLPPSYQPAAPAAAAQWPAQPGQQPAAAPPQPGPMPGRQPQATGGQGPAGMPGQQPPFQPQAPQPAPAAWHQPNQAGQATPAHQPGQPGQPGAPGAPAPGPQPAPDGPTPPSGYGFPQPGTPAPGAPTPPAQPGGYGFPQPPAPQPHSNGPTPPSGYGFPQPGAVNPPAQPGGYGFPQPGNPDPQAQQGGYGFPQPPQHPDGAPGAPHAPVDPRSGAAWPQPLQHDQRQPTNPGAAPLGYTAAVELSSDRLLNNKKQKAKSGRPAAAGGRFKLGGKKEEAERQRKLELIRTPVLSCYRIAVISLKGGVGKTTTTTALGSTLATERQDKILAIDANPDAGTLGRRVRRETGATIRDLVQAIPYLNSYMDIRRFTSQAPSGLEIIANDVDPAVSTTFNDEDYRRAIDVLGRQYPVILTDSGTGLLYSAMRGVLDLADQLIIISTPSVDGASSASTTLDWLSAHGYADLVSRSLTVISGVRETGKMIKVEDIVAHFETRTRGVIVVPFDEHLAAGAEVDLDMMRPKTREAYFNLAAMVAEDFTRHQQAHGLWTSDGNPPPVAAPPMPGGPMPSQPMPGQPMPGQPMPGQPVPEQLYGAGQPYPQAPGQPYPPAPGQPYAPAQQPYPPQQGQPQPYPGAPQQPGYPQTGQPQPQPQPPSQPQPQPQPGQQPQQPPQAPPAPPQQ
>NZ_CP013219.1|WP_058082107.1|6111932_6112682_-|hypothetical-protein
MTMTTSPTPSRPGLGERLRTGFGLLGPRHPRHTLPVEQVDTLTLPIGDDGVVVGVNNEGQPAILGVNRPTPYDIVLIGGLWTAQVMALRSAATGARVAVETGRPQAWMQMVHAMGGGQNGLSVYDVGRVPPQGASAGTPVLVVRDCGMRPPRGRVVSGPWQSVLTLLPYLSPVAPRLLRQARLAGIQRVSPDEAAELGRTMGLSRTEVESLPGLPDGVTLWCTDRDRQYVLTQPTDAEVGLLGTPRRMD
>NZ_CP013219.1|WP_058082108.1|6112681_6114043_-|type-VII-secretion-protein-EccE
MASATRTRSRSQSGSRSSGARRSGARGSSSGRDDAHQAPTPYQGAFAPRLESRSGRGGSFAVQRLVLLEIAGALALCGWLIGTMALIAVTPVSLVFVVLAVVRRRGRSLPEWLGTLLAMRSRIRRAASTPVPPGTDSGLAPAVECDPTLRTFSFNRGDDRDQRPIGMVGDGGFLTAVLQVESDVDALRAERGRRPLPMALVRDVLEVDGIQLESAQIVVHTQPAPALHLPQQSVVVSNYAPLQAQTGSPAVRITWIALKLDPELCPEAVAARGGGLLGAQKCLARSAEHLSSRLTGAGFRANVLTEEELTAAIATSACANPMVTAQAGRGEAPQRRTEESSRSWRCDNRRHTTYWVRRWPQLGGSGGSLAQLVAQLTAVPALATTFSLTLAKGAQQDVTVTGHVRITGRSKQELTDARRDLERAAQQARTGLARLDREQLPGVLATLPLGGAR
>NZ_CP013219.1|WP_058082109.1|6114250_6115774_+|type-VII-secretion-protein-EccB
MASRRDELNAYTFAKRRTLASFLRPSPSGSEEGAPKPLGALVPGVVVGVVILAVFGAIGMFSPTAPKGWDTPEEHVIVASKSTTRYVVLKTGKQKQLHPVLNMASAKLLLDPGKASVITVDEGILDSGKPPHGATIGIPYAPDRLPSPEEAEAAKRWAVCERPADGGRAIQKAAFVLAKKEWSKTEGADRLTRGDLMYVVGPDGKTQYVVDARGTAYKLADPGDKELLKALDTRGRAPQRVSQEWLDTLRKGDPIAIPPIEGTPGAKADAGIMPAQYDKVGEVIKAYDGQVLRYYVVLRGEVARISEFTATLLLNSGQLVGVGQAGEAQQVSPGAVADSTAFEEDKNWPTYKPRTVNDGSSATSGRNTVCNVLRSVGAKGATTLSTWVGKDFPAQLPTGSSSAYVTAGSGQLYRQFQGTETTAGGVFLVTDTGLRYALQSNSDSATDDKGIGTSAKKRKEELAEAKIAQTRLGYEKLTPTPIPLEWSTFLPTGPRLSEAAARQPQGS
>NZ_CP013219.1|WP_058082110.1|6115798_6117064_+|type-VII-secretion-associated-serine-protease-mycosin
MLKARTSEAATRAVVVAAAVALTAATTVLALPPSPARADDGQCTFPSKPYAGRPWALQRVNLDELWAQSTGKGVQVAVIDTGVDVRNPQLTKAVDASKGKNLLPDKNRKGEKIDRGNKSGTTDTVGHGTRVAGIIAARPAKGTGFVGLAPDATIIPIKQNDAEGDGTADSLASAITYAVQAGADVINISQDTAEALDPKTSKLKDAVDYALGHKVVVVASAGNDGLGGNVKVTYPASYEGVLAVAASDRNNERAAFSQSGDFVGVSAPGVDMISTVPGNGHCSDNGTSFSAPYVAGVAALLKSKYPDWTAQQVVAQIEQTAERAIPGRDRLVGWGVVDPVKALTEVDPAHPVESPKPENGVARGEAPSVTPLHFGETAEERDNRLATYTVVGGLVLVAGLTGTAVAVRDARRRRSGRPRAS
>NZ_CP013219.1|WP_058082111.1|6117173_6117527_-|DUF4333-domain-containing-protein
MAIARTSAAAWSISAVAAGVLLVGCSGSVTVEKSEPKLSAGKLADTVSEKLAAQTGRPKPDVTCPEDLAGKVGTTTRCTLTADDGSTLGVTVTVSSVKGSQINFDLKADDKASPPAR
>NZ_CP013219.1|WP_159103833.1|6117658_6118357_-|hypothetical-protein
MLIDALNDRRAKCSIGTCEHQKANSSMNFDDLPHPTKRRNVVIVNDREIPRRHFLLAAAGVFVLFGDAFSGIVWAGWSDTQENSRGDEEVSALVALARRRGWTYRARVAGGADRYEGAAPFPDVSSGLSVWDCVEGRHRGRTVRCFEYRDVRTVQSAGPGRSLTKTSYYAVFSVTAADTVRGSVLRAADADGSLRFDGGELITWTKGRLREEDVLPKLDYLCNVLDRASDSR
>NZ_CP013219.1|WP_159103834.1|6118392_6118704_+|hypothetical-protein
MADPDLGADSQSLKKGAKDIAEALRPTEGFDLEESAGRSSSFGHSSASSSFVAFCATWQAGAQILSGSTAQRAAGLISASGTLTDTDGQVRNAANSVKTNQGK

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Crispr_ID: NZ_CP013219_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013219_12

6250436-6250659

Orphan

Consensus_repeat	Method
GGTGCCCGTTCGGACGCCGGGCGTCCGCAGCCTGAGGAGAACGGATGAGCG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP013219_12

>merge|NZ_CP013219|12|6250436-6250659|PILER-CR
GGTGCCCGTTCGGACGCCGGGCGTCCGCAGCCTGAGGAGAACGGATGAGCGTCGGCCGGTGTGAGTCGGGACGGGTGTCGGGCGCGCAGGGGAATGGCCACCGTCCACCGGGCGTCCGCAGCCCGATCACCACGCGCACGCGTGCGGTGGGTCCAGGCGACGCCTCCGCCGGTGGTGCCCGTTCGGACGCCGGGCGTCCGCAGCCTGAGGAGAACGGATGAGCG

>NZ_CP013219|12|2|6250436-6250659|PILER-CR
GGTGCCCGTTCGGACGCCGGGCGTCCGCAGCCTGAGGAGAACGGATGAGCG	TCGGCCGGTGTGAGTCGGGACGGGTGTCGGGCGCGCAGGGGAATGGCCACCGTCCA
CCGGGCGTCCGCAGCCCGATCACCACGCGCACGCGTGCGGTGGGTCCAGGC	GACGCCTCCGCCGGTGGTGCCCGTTCGGACGCCGGGCGTCCGCAGCCT
GAGGAGAACGGATGAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013219.1\|WP_058082178.1\|6246612_6248778_-\|RecQ-family-ATP-dependent-DNA-helicase	unknown	unknown	gnl\|CDD\|223588
NZ_CP013219.1\|WP_014675460.1\|6238989_6239649_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP013219.1\|WP_058082184.1\|6264585_6265122_+\|DUF1453-family-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058082180.1\|6251314_6253264_+\|glycogen-debranching-protein	unknown	unknown	gnl\|CDD\|225942
NZ_CP013219.1\|WP_079088104.1\|6242730_6243285_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NZ_CP013219.1\|WP_079082428.1\|6242419_6242668_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058084062.1\|6244307_6244775_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058082176.1\|6243372_6244074_+\|ribonuclease-HII	unknown	unknown	gnl\|CDD\|234574
NZ_CP013219.1\|WP_014675477.1\|6261864_6263988_+\|type-IIA-DNA-topoisomerase-subunit-B	unknown	unknown	gnl\|CDD\|235501
NZ_CP013219.1\|WP_058082183.1\|6260238_6261093_+\|serine-protease	unknown	unknown	gnl\|CDD\|238113
NZ_CP013219.1\|WP_058082185.1\|6265118_6266270_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP013219.1\|WP_058082174.1\|6239661_6240567_+\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NZ_CP013219.1\|WP_058082177.1\|6245395_6246016_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_051009732.1\|6257253_6258141_+\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP013219.1\|WP_058084063.1\|6258576_6260118_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|235640
NZ_CP013219.1\|WP_058084061.1\|6240931_6242440_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP013219.1\|WP_014675476.1\|6261192_6261423_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013219.1\|WP_058082173.1\|6238234_6238840_+\|YdbC-family-protein	unknown	unknown	gnl\|CDD\|374476
NZ_CP013219.1\|WP_058082181.1\|6253416_6254175_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NZ_CP013219.1\|WP_058082182.1\|6254337_6257091_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054

Protein	Function_ID	Function_description	E-value
NZ_CP013219.1\|WP_058082178.1\|6246612_6248778_-\|RecQ-family-ATP-dependent-DNA-helicase	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	2.1361e-125
NZ_CP013219.1\|WP_014675460.1\|6238989_6239649_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	5.7892e-35
NZ_CP013219.1\|WP_058082180.1\|6251314_6253264_+\|glycogen-debranching-protein	gnl\|CDD\|225942	COG3408, GDB1, Glycogen debranching enzyme [Carbohydrate transport and metabolism].	1.89984e-23
NZ_CP013219.1\|WP_079088104.1\|6242730_6243285_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	6.66794e-17
NZ_CP013219.1\|WP_058082176.1\|6243372_6244074_+\|ribonuclease-HII	gnl\|CDD\|234574	PRK00015, rnhB, ribonuclease HII; Validated.	1.2469e-85
NZ_CP013219.1\|WP_014675477.1\|6261864_6263988_+\|type-IIA-DNA-topoisomerase-subunit-B	gnl\|CDD\|235501	PRK05559, PRK05559, DNA topoisomerase IV subunit B; Reviewed.	0
NZ_CP013219.1\|WP_058082183.1\|6260238_6261093_+\|serine-protease	gnl\|CDD\|238113	cd00190, Tryp_SPc, Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.	7.46985e-67
NZ_CP013219.1\|WP_058082174.1\|6239661_6240567_+\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	3.94324e-45
NZ_CP013219.1\|WP_058082185.1\|6265118_6266270_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.51875e-41
NZ_CP013219.1\|WP_051009732.1\|6257253_6258141_+\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	2.35265e-45
NZ_CP013219.1\|WP_058084063.1\|6258576_6260118_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	0
NZ_CP013219.1\|WP_058084061.1\|6240931_6242440_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.41423e-65
NZ_CP013219.1\|WP_058082173.1\|6238234_6238840_+\|YdbC-family-protein	gnl\|CDD\|374476	pfam16291, DUF4937, Domain of unknown function (DUF4937. This family consists of uncharacterized proteins around 120 residues in length and is mainly found in various Bacillus species, such as Bacillus subtilis and Bacillus amyloliquefaciens. Several members are annotated as ydbC, but the specific function of this family is unknown.	8.55665e-42
NZ_CP013219.1\|WP_058082181.1\|6253416_6254175_+\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	1.91835e-29
NZ_CP013219.1\|WP_058082182.1\|6254337_6257091_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.41723e-43

>NZ_CP013219.1|WP_058082178.1|6246612_6248778_-|RecQ-family-ATP-dependent-DNA-helicase
MEHTSNADLRAQADAVLARLVGDATGAARLREDQWRAIEALVADQRRALVVQRTGWGKSAVYFVATSLLRARGSGPTVIVSPLLALMRNQVDAAGRAGIHARTINSANTEEWEAVQAEIAAGDVDVLLVSPERLNNPDFRDQVLPKLSAATGLLVVDEAHCISDWGHDFRPDYRRLRTMLADLPPGVPVLATTATANARVTADVAEQLGTGGTSDALVLRGPLDRESLSLGVLRLPDAAHRMAWLADHLDDLPGSGIVYTLTVAAAEEVTAFLRQRGHAVAPYTGKTENAERQQAEDDLLANRVKALVATSALGMGFDKPDLGFVVHLGSPSSPIAYYQQVGRAGRGVDHAEVLLLPGREDEAIWQYFASLAFPSEDLVRRTLDVLARADGPLSLPALEPLVELRRSRLETMLKVLDVDGAVRRVKGGWIATGQPWSYDADRYAWVARQRAAEQQAMREYATTTECRMEFLQRQLDDEGAKPCGRCDNCTGPRFTSGLSPAALDAARSDLGRAGVEVEPRRMWPTGLPAIGIDLKGRIPAGDQASPGRALGRLSDIGWGNRLRPLLAPQTPDAAVPDDVARAVVDVLADWARGPGGWASGAPDAPSRPVGVVTVASRSRPRLIHSLGTRIAEVGRLPLLGSVEYAGDAPRSPRSNSAQRLKVLDGALTVPPDLASALAAGNGPVLLVDDFTETGWTLAVAARLLRKSGARGVLPLVLAVQG
>NZ_CP013219.1|WP_058082177.1|6245395_6246016_-|hypothetical-protein
MTFGFASSSAASLSTSTSAASASRLLEPAEWAAAGIPLLRNPREVVSGLHARHHPKPLTAIVAVLDPDERLRASASFTRRPAAADGWMFRNALLAQLRRVIPHDLRRRTPVRTAVLLYCREGDARWTEEDGAWMWGLRDACTLHGLRCGAYITLTHDGWQVLGEGRGGRRPNAHSAPEPFATAEAPPLVPRSGGPVSEVLRRAAAR
>NZ_CP013219.1|WP_058084062.1|6244307_6244775_+|hypothetical-protein
MQRTPRDVAPAKPGPSGPAAPAATAASPQIQLIPASAEGALDAAEEAVDLLLDSGRAPGDVLVITTGAQHPWAEHELSFGETSYWAQHDAGDDVFYADAAVASRAASRPVVVVAVNGGPASAAATALPLAHSRAGALLIVCGDPQQINSVLGAGV
>NZ_CP013219.1|WP_058082176.1|6243372_6244074_+|ribonuclease-HII
MPYEPPTHTVERSLRATTGAKVIAGVDEVGRGAWAGPVTVCAAITGLRRPPEGLTDSKLLTVKRRTELALILQSWVTAYALGHASPEEIDDLGMTAALRLAAVRALDALPVRPDAVILDGKHDYLGDPWQVRTVIKGDRSCVAVAAASVIAKVQRDKMMAELGIDHADFGFADNAGYPSPVHKAALEERGPTPHHRLSWAYLDALPQWRHLKKVRSWADGSVPEIEGQLVLDF
>NZ_CP013219.1|WP_079088104.1|6242730_6243285_+|TetR/AcrR-family-transcriptional-regulator
MLERAILDAALEQLSTVGWKGLTMEGVAAGAQTGKAAVYRRWPSKEDLVADALVSGLPRVEEAPDLGSVREDLLTLCRQVRRIMYSRPGVALRSVIHECDHVQVGRFEGVIFGTVVEPTVRLLREVITRGIERGEVRSDAANGYVFDAIPAMMMYRSKMCASEWSDQDLEEMVDQLMLPLLRPY
>NZ_CP013219.1|WP_079082428.1|6242419_6242668_+|hypothetical-protein
MPLPAGHARFPIVLEQLRGRHCGSPIQALVNARVHFRVHGSESPTVNASVHLIVRHVPRPPVAAARRHFPRNPRFPCMLEKH
>NZ_CP013219.1|WP_058084061.1|6240931_6242440_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MARREGHPGIALTVIAACQLMVVLDATIVNIALPHIQEALKFSTTDLTWVVSAYTLTFGGLLLLGARAGDILGRRRVFMAGILLFTFASLLGGLAQEPWQLLAARALQGVGGAIASPTSLALITTTSPEGPERNRAFGVFAAVSAGGGAIGLLAGGMLTDWLDWRWVLFVNVPIGVLIASLAPLYINESERHPGRFDLTGALTSTVGMASLVYGFIRAAEDGWRDGLTLGSFGAAVVLLFAFVFTEMRAKEPITPLRMFADRNRWGTYVIMLCLAAAMFGMFFYIVLFVQNVLGYSAIKAGLAFLPVTAAISVGAGLSQRLLPVLGPKPFMMGGSALVAVGLVWQAFIRPDSTYVGGVLGPMLVFGFGMGLNFVTATVTAVSGVAPHEAGAASGLLNAMQQVGGSLGLSILTTVFGSASTDEAKKQLPKFLADSSPEQKAQFAKTHQLPAPWGHDVLAHGISTAFIPAAAMAALAFLTAWLVLRVRKGDLDSLAGTAGPHLG
>NZ_CP013219.1|WP_058082174.1|6239661_6240567_+|ADP-ribosylglycohydrolase-family-protein
MTADSSSLVRLERALASLRGLAVGDALGSQFFVPANHPLLKRRELPAGPWQWTDDTEMACSVVAVLATHHRIDQDALARSFAEHHDFDRGYGPAVNRLLRLVREGEDWRRLAAGLFNGQGSWGNGAAMRIAPLGAWYADDPEQATHQAEISAYTTHQHREAVVGAMAVAAAAAMVGSPDGPPAPEALLDGVIALVPKSAVGQGLRRARDMLDYGDAATVAAVLGCGRRTTAHDTVPFALWSAARCLGDYTSAFWTTAQVGGDVDTTCAIVGGVLAAAEAGAPPAEWVRHTEALPDWVPAGS
>NZ_CP013219.1|WP_014675460.1|6238989_6239649_+|histidine-phosphatase-family-protein
MARPRRIVLVRHGESTGNADDSVYEREPDHALALTERGWRQAEETGKRLREVFGRERVSVYVSPYRRTHETLRAFHLDPDLIRVREEPRLREQDWGNWQDRDDVRLQKAYRDAYGHFFFRFPQGESGADVYDRVGGFLESLFRSFEAPDHPPNVLLVTHGLAMRLFCMRWFHWTVAEFESLSNPGNAEVRMLVLGEDGKYTLDRPFERWREPVPYWANG
>NZ_CP013219.1|WP_058082173.1|6238234_6238840_+|YdbC-family-protein
MLVKWIRCTVVDRRGFERGQRKWAGLPGEPGFRGQGGGWSRQRAGVAHIFTFWESRAFYDSFMARSHDRLAAAQSGTFKDAQVKLFEYRFDVKTGFEPRFTDADLIRVALCRIHEERVEHFTLMQEKVWNPAMAGSPGMIRGMFGEAPEQEFLILSMWRSAAEHGKYRTERVERLALRAQTEADIASLSGDIVDLEPSWTV
>NZ_CP013219.1|WP_058082180.1|6251314_6253264_+|glycogen-debranching-protein
MPELPPTHTALICVALPGLAISGESGQLAGRGLDGFYRGGRRLLSRCQVRVAGREPLPVQARMTGADSARFVGTLRTSAAAGPDPDVVVERTRHADGTERITLRSAAPRPLRLPVEVALGTDLAELGAIAAGTAGPELPASVHDSGLRWAEADTAACVTADPSPTDALASAGLLCWELELPPGGTASVELRVRPEGAGPLRAAGHAATSPVALARAAGDDPRVGPLLHSAVADLQALLLRDPAHPSDTYLAAGAPWRCGMAPAEALAAARMTLPLGTRLAAGTLRTLARTQLQGPGPRTGMIPGPRRDAGPHLPPGCTATEATLLFPVLLAEARRWGLPEQETQELLPSAERCLTWLRTTVRDGIYLSDPHPAGPARCETQAHAHRAALLGADLLDAYDRPGATELRQWAQTLRSAFRADFWVEDRSGGRPAMALTPDGRPVPHLAATAVHLLDTGLLGAGMFAPGLLDKVHTAHLARLLGTPAMDAGWGLRGLGTREAGHNPFGHRTGAVRVQETALAVAGLAAAGYEKEAAGLLNGLLDAAEHFGHRLPEMFAGEHRSAGTAPLPHPAACRPAATAAASVVLLLTVLAGIRPDAPARTVTLRPVRSAPLGELGLSGLRVAGAPFAVRISRLGLAMVEEAADGLQLGA
>NZ_CP013219.1|WP_058082181.1|6253416_6254175_+|NUDIX-hydrolase
MPYDPSAFPPFAVTVDLVVLTVRRHSLCALAVRRGEPPFQGRWALPGGFVRADEDLSQAAARELAEETGLCAHDPSVPAQDNGAHLEQLATYGDPKRDPRMRVVSVAHLALAPDLPAPRAGGDASNARWAPVEELLQQGGYGRGGEPVAPLAFDHAQILADGVERARSKIEYSSLATAFCPPEFTVGELRRVYEAVWGVALDPRNFHRKVTGTPGFLVPTGGTTTRQGGRPAQLFRAGGATLLNPPMLRPEV
>NZ_CP013219.1|WP_058082182.1|6254337_6257091_+|ATP-binding-cassette-domain-containing-protein
MIQAFGLTSNPRKAHPPAVDDVSFEARAGHVTALLGAAGAGKTTALKLMLELQPGRGITYFKGRPLHRIAHPSREVGVLLGDVPGHPSRSVRGHLRMLCAASGVPARRADEILEAVGLVSLRDERLGTLSRGMDRRLGLACALLPDPHTLVLDEPADGLSAREAQWLHSTLRAYAVQGGTVLFTTADTKEAARTADRVVTLDAGRVVADQEARAFARTRLRPRVAVRSPHAVRLAALLTKDARTTRRSVEVVREGGNRLSVYGTTTADVGEIAFRHGILVHQLADEIGDMGPGAGAESDAGVCSTEPLPTVPDSSRVERETRQDRTPAEPEPAAPETPYEKPKQASAGPSWARRRRTVPGCPAPEPAPGSALEPGSAALGDSPENPRGTVDELPAAPERARPGSEETATPALHAADSRATEPPVESRAPAADAATGGTRATTSDRSAPEPDTAAPGHSSVGTTIAGQPSGRREHALDSSAPESERAVRGLSPVGEGPLAPGLAARERGRTADGERTAPGRGLGQGGTAERPLIVSGATAHDAPSAGAAADGTHGRGGVAASGEKNTAGAEAGDTSARATGGRSTDPAATPDSGPGGVATASEPQTGRTRTPTATVTGTRTLLPGARNPAARQQRTGRAARPDGVRPFPAASALPPPISVHPARSPLRPLRYEIRRAGGIGTGFLICGAVLVVSAFIAVLLARLGHTPQARLFAAWPRELPLPPAALAAGLLGALAFGDEFRHPALAADRGTVPRRLGLLTAKLLVSGATAVLLAFLTVGCDAEVLYIVYGRELTQVPADWLSLIASWFGLVVGCAWAGVLAAGVFRSTTAGLAAVLAVPVLVVPLVHKAMQGPAVRMAADFPVRMREVFLLRWPFGGERYLVAAVRVLAQPVGGALALSLLALLCAYLLTALRIRFR
>NZ_CP013219.1|WP_051009732.1|6257253_6258141_+|FadR-family-transcriptional-regulator
MSTLAHTMMTAARSTDSGLAGPGELDRYPYAEAPVTDRVGAPAWDGGDPELGRVGRRASGSRGRGLHGQLVQQLGQMIVSGDLGADRPLVPEEIGQRFEVSRTVVRESLRVLEAKGLVSARPNVGTRVRPVSDWNLLDPDIIEWRAFGPQRDDQRRELSELRWTIEPLAARLAAGHGREEVQQRLCDMVEIMSHALAQGDALTYSRADTEFHALLIQIAGNRMLEHLSGIVSAALQVSGGPVTGCDRPNEASLAQHARIVDALGTGDGTAAETAMRQLLTVHPEVERVVPAPREH
>NZ_CP013219.1|WP_058084063.1|6258576_6260118_+|RNA-polymerase-sigma-factor
MSASTSRTLPPEIAESVSVMALIERGKAEGQIAGDDVRRAFEADQIPATQWKNVLRSLNQILEEEGVTLMVSAAEPKRTRKSVAAKSPAKRTATKTVAAKTVTTRKATATTAAPAAPAAPASADSAEEAAPAKKAVAKKVTAKKTVAKKAVAKKTAAKKTTAKKDDVELLEDEVLEDTKVADEPEGAESAGFVLSDEDEDDAPAQQVAAAGATADPVKDYLKQIGKVPLLNAEQEVELAKRIEAGLFAEDKLANADKLAPKLKRELEIIAEDGRRAKNHLLEANLRLVVSLAKRYTGRGMLFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLARVQRQMLQDLGREPTPEELAKELDMTPEKVIEVQKYGREPISLHTPLGEDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHSVLDTLSEREAGVVSMRFGLTDGQPKTLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
>NZ_CP013219.1|WP_058082183.1|6260238_6261093_+|serine-protease
MRRSVVRALIRPLALAATMTAIPLMSAAPAASDSVVVGGFPIDVSQSPWTVALASRDRFGGMRAGQFCGAVAVGRTTVVTAAHCLSEEALGTPPDRVRDLKVIAGRTDLLSEQGDEIDVREIRLNPAYDVTTHSGDFAVLGLAGPLPQSAVVPMAGAGDPAYAPGTRAVVSGWGDTTGAGSYAHRLHAARVRVLPDEMCARAFPGGPEGAYRAATMLCAGEVGGGPDACQGDSGGPLVAGGRLIGLVSWGSGCGRPGLPGVYTRVSEVVRALRPTAGTEPSGRS
>NZ_CP013219.1|WP_014675476.1|6261192_6261423_-|hypothetical-protein
MTTVLTPASPLTAADRCDRCGAQAYLRVVLLSGGELLFCAHHGRKFEPELKKIAAEIQDETERLTSVPNTASDEER
>NZ_CP013219.1|WP_014675477.1|6261864_6263988_+|type-IIA-DNA-topoisomerase-subunit-B
MTADTSVPSTALLAGADRDGSNYTARHLLVLEGLEAVRKRPGMYIGSTDSRGLMHCLWEIIDNSVDEALGGYCDHIEVILHDDGSVEVRDNGRGIPVDVEPKTGLSGVEVVMTKLHAGGKFGGGSYAASGGLHGVGASVVNALSARLDVEVDRGGHTHAISFRRGVPGAFSAEGADAKFEAKSGLRKAKKIPKTRTGTRVRYWADRQIFLKDAKLSLENLHQRARQTAFLVPGLTIVVRDEFGLGEGGSKGEESFRFDGGISEFCEYLANDKAICDVLRFSGRGTFKETVPVLDEHGQMTPTEVTRELGVDVAMRWGTGYDTTVRSFVNIIATPKGGTHVTGFEQALTQTLNDVLRAKKMLRVAEDNIVKDDALEGLTAVVTVRLAEPQFEGQTKEVLGTSAARRIVNSVISKELKAFLTATKRDAAAQARVVMEKVVAAARTRVAARQHKDAQRRKTALESSSLPAKLADCRSDDVDRSELFIVEGDSALGTAKLARNSEFQALLPIRGKILNVQRSSVTDMLKNAECGAIIQVIGAGSGRTFDIDQARYGKIIMMTDADVDGSHIRCLLLTLFQRYMRPMVEAGRVFAAVPPLHRIELIQPKKGQEKYVYTYSDRELRDKLMEFQSKGIRYKDSIQRYKGLGEMDADQLAETTMDPRHRTLRRINLSDLEAAEQVFDLLMGNDVAPRKEFISSSAATLDRSRIDA
>NZ_CP013219.1|WP_058082184.1|6264585_6265122_+|DUF1453-family-protein
MDGLVNVLVTVAVVAIVIARQFRARAIDTDRRWWLLPVILAVVALREPGILDPGHRAESAVLLVAELFIGLVTGVGWGWTTRLWTAPDGVVWTKSSKASGAVWIVGIALRAGVFALGSALGVHQDSSALMLGLAGTLLVRGGILTWRARSVGAPSRPTPSRPAPAYGDDERSAWKERV
>NZ_CP013219.1|WP_058082185.1|6265118_6266270_+|sensor-histidine-kinase
MTENAWTRWPSREALGRSGTTRPRRMLVWAVRLLLLAVLLWGVFSQRHVGRWEALAAAAAILLAGLVSWTFFRTTYEHRLVPSLALMGVLLGIAVAAEATGFTGPALVIWCGCGVSALERLPLGAAVPVASVALASYSAFTNDVWLTTAATVAGMALAGYVLRLDAEARGSAQRLLAQERAARAAEAESAALAERARIAREIHDVLAHSLSAQLVHLEAARLLIENGADRERILDRVVAARGMARDGLAETRQALSALRGELTPLEDFLAELVSTADGAEVTVTGERRPLPAEASQAVRRVAQEALTNVRKHAQGAKVTVRLDYSEHEVTLNVRDSGGEAGELNGSGGGYGLLGMRERAELLGGSLDAGPDEEGFVVTLKVPV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP013219_2	2.1\|873935\|14\|NZ_CP013219\|PILER-CR	873935-873948	14	NZ_CP013220.1	822757-822770	0	1.0
NZ_CP013219_12	12.2\|6250594\|48\|NZ_CP013219\|PILER-CR	6250594-6250641	48	NZ_CP013219.1	6250388-6250435	0	1.0

1. spacer 2.1|873935|14|NZ_CP013219|PILER-CR matches to position: 822757-822770, mismatch: 0, identity: 1.0

tcccgtgggcgagc	CRISPR spacer
tcccgtgggcgagc	Protospacer
**************

2. spacer 12.2|6250594|48|NZ_CP013219|PILER-CR matches to position: 6250388-6250435, mismatch: 0, identity: 1.0

atcaccacgcgcacgcgtgcggtgggtccaggcgacgcctccgccggt	CRISPR spacer
atcaccacgcgcacgcgtgcggtgggtccaggcgacgcctccgccggt	Protospacer
************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP013219_2	2.2\|873983\|24\|NZ_CP013219\|PILER-CR	873983-874006	24	NC_013856	Azospirillum sp. B510 plasmid pAB510b, complete sequence	227421-227444	3	0.875
NZ_CP013219_2	2.2\|873983\|24\|NZ_CP013219\|PILER-CR	873983-874006	24	NZ_CP024314	Rhizobium sp. NXC24 plasmid pRspNXC24c, complete sequence	2166145-2166168	3	0.875
NZ_CP013219_2	2.2\|873983\|24\|NZ_CP013219\|PILER-CR	873983-874006	24	NZ_CP020399	Burkholderia multivorans strain FDAARGOS_246 plasmid unnamed, complete sequence	208105-208128	3	0.875
NZ_CP013219_6	6.2\|2974512\|31\|NZ_CP013219\|CRT	2974512-2974542	31	NZ_LR134454	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 12, complete sequence	221047-221077	5	0.839
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	1102792-1102822	6	0.806
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	710334-710364	6	0.806
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_CP034351	Streptomyces sp. W1SF4 plasmid p1, complete sequence	293323-293353	6	0.806
NZ_CP013219_6	6.2\|2974512\|31\|NZ_CP013219\|CRT	2974512-2974542	31	NC_017805	Deinococcus gobiensis I-0 plasmid P1, complete sequence	268757-268787	6	0.806
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_LR134455	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 13, complete sequence	106618-106648	7	0.774
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	5155781-5155811	7	0.774
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NC_013857	Azospirillum sp. B510 plasmid pAB510c, complete sequence	534963-534993	7	0.774
NZ_CP013219_6	6.2\|2974512\|31\|NZ_CP013219\|CRT	2974512-2974542	31	NZ_CP054621	Azospirillum oryzae strain KACC 14407 plasmid unnamed6, complete sequence	20071-20101	7	0.774
NZ_CP013219_6	6.2\|2974512\|31\|NZ_CP013219\|CRT	2974512-2974542	31	NZ_CP018229	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence	497985-498015	7	0.774
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	CP000385	Mycobacterium sp. MCS Plasmid1, complete sequence	44541-44571	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NC_008704	Mycobacterium sp. KMS plasmid pMKMS02, complete sequence	70600-70630	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	MK977696	Gordonia phage SCentae, complete genome	83826-83856	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_CP012940	Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence	22048-22078	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_CP012944	Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence	1953763-1953793	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NC_017966	Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence	50215-50245	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NC_017575	Ralstonia solanacearum Po82 megaplasmid, complete sequence	49155-49185	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_CP026308	Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence	49155-49185	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_CP051295	Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence	21724-21754	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_CP026091	Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence	49179-49209	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NC_014309	Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome	42129-42159	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_CP044185	Salmonella enterica subsp. enterica strain AR-0403 plasmid pAR-0403	11848-11878	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_CP026093	Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence	49173-49203	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_CP021767	Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence	50035-50065	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NC_010392	Phage Gifsy-1, complete genome	10896-10926	8	0.742
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	525700-525730	9	0.71
NZ_CP013219_4	4.1\|2631332\|31\|NZ_CP013219\|CRISPRCasFinder	2631332-2631362	31	NZ_CP020695	Sulfitobacter sp. D7 plasmid p1SUD7, complete sequence	157325-157355	10	0.677

1. spacer 2.2|873983|24|NZ_CP013219|PILER-CR matches to NC_013856 (Azospirillum sp. B510 plasmid pAB510b, complete sequence) position: , mismatch: 3, identity: 0.875

gccaccgtccggtgtcttgccgtt	CRISPR spacer
ggcaccgtccggtgtcttgccggg	Protospacer
* ********************

2. spacer 2.2|873983|24|NZ_CP013219|PILER-CR matches to NZ_CP024314 (Rhizobium sp. NXC24 plasmid pRspNXC24c, complete sequence) position: , mismatch: 3, identity: 0.875

gccaccgtccggtgtcttgccgtt	CRISPR spacer
gccaccgtccggtgtcttgacggg	Protospacer
******************* **

3. spacer 2.2|873983|24|NZ_CP013219|PILER-CR matches to NZ_CP020399 (Burkholderia multivorans strain FDAARGOS_246 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.875

gccaccgtccggtgtcttgccgtt	CRISPR spacer
gtcaacgtccggtgtcttgccgtc	Protospacer
*.** ******************.

4. spacer 6.2|2974512|31|NZ_CP013219|CRT matches to NZ_LR134454 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 12, complete sequence) position: , mismatch: 5, identity: 0.839

tgggcacggtgcgggagggcttgcctcgccg-	CRISPR spacer
cgggcacggtgcgggagtgcctg-cgcgccgt	Protospacer
.**************** **.** * *****

5. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 6, identity: 0.806

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ccaccccggcgcggcgggccagcccggcgca	Protospacer
*.  ********** ***** *********

6. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 6, identity: 0.806

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ccaccccggcgcggcgggccagcccggcgca	Protospacer
*.  ********** ***** *********

7. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_CP034351 (Streptomyces sp. W1SF4 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.806

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
cctgcccgccgcggggggcctgccctccgag	Protospacer
*.****** ****************  **

8. spacer 6.2|2974512|31|NZ_CP013219|CRT matches to NC_017805 (Deinococcus gobiensis I-0 plasmid P1, complete sequence) position: , mismatch: 6, identity: 0.806

tgggcacggtgcgggagggcttgcctcgccg----	CRISPR spacer
tgggcgcggtgcgggagggct----tcgcggatgc	Protospacer
*****.***************    **** *

9. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_LR134455 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 13, complete sequence) position: , mismatch: 7, identity: 0.774

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ttccgccggcgcggcgggcctgcccgacgcg	Protospacer
.*.  ********* ***********.***

10. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 7, identity: 0.774

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
caaggccggcgcggtgggcctgcccgccgac	Protospacer
*  * ********* *********** ** .

11. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NC_013857 (Azospirillum sp. B510 plasmid pAB510c, complete sequence) position: , mismatch: 7, identity: 0.774

cttgcc--cggcgcggggggcctgcccggcgct	CRISPR spacer
--tggcgggggcgcggggggcgtgccgggcgcg	Protospacer
  ** *   ************ **** *****

12. spacer 6.2|2974512|31|NZ_CP013219|CRT matches to NZ_CP054621 (Azospirillum oryzae strain KACC 14407 plasmid unnamed6, complete sequence) position: , mismatch: 7, identity: 0.774

tgggcacggtgcgggagggcttgcctcgccg	CRISPR spacer
tgggcacggtgccggagggcttccgcgagcg	Protospacer
************ ********* * . . **

13. spacer 6.2|2974512|31|NZ_CP013219|CRT matches to NZ_CP018229 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.774

tgggcacggtgcgggagggcttgcctcgccg	CRISPR spacer
tgtcaacggtgcgggagcgctcgcctcgttg	Protospacer
**   ************ ***.******..*

14. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to CP000385 (Mycobacterium sp. MCS Plasmid1, complete sequence) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
tcagtgcggcgcggcgggcctgctcggcgcg	Protospacer
.. *. ******** ********.******

15. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NC_008704 (Mycobacterium sp. KMS plasmid pMKMS02, complete sequence) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
tcagtgcggcgcggcgggcctgctcggcgcg	Protospacer
.. *. ******** ********.******

16. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to MK977696 (Gordonia phage SCentae, complete genome) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ccagcccggctcgggcggcctgcccgggcag	Protospacer
*. ******* **** ***********

17. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_CP012940 (Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ccagagcggcggggcgggcctgcccggcgtg	Protospacer
*. *  ***** ** **************.

18. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_CP012944 (Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ccagagcggcggggcgggcctgcccggcgtg	Protospacer
*. *  ***** ** **************.

19. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NC_017966 (Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
cacgcccggcgcgcagggcctgcccgatgtg	Protospacer
* .********** .***********..*.

20. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NC_017575 (Ralstonia solanacearum Po82 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ccagagcggcggggcgggcctgcccggcgtg	Protospacer
*. *  ***** ** **************.

21. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_CP026308 (Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ccagagcggcggggcgggcctgcccggcgtg	Protospacer
*. *  ***** ** **************.

22. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_CP051295 (Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ccagagcggcggggcgggcctgcccggcgtg	Protospacer
*. *  ***** ** **************.

23. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_CP026091 (Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ccagagcggcggggcgggcctgcccggcgtg	Protospacer
*. *  ***** ** **************.

24. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NC_014309 (Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ccagagcggcggggcgggcctgcccggcgtg	Protospacer
*. *  ***** ** **************.

25. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_CP044185 (Salmonella enterica subsp. enterica strain AR-0403 plasmid pAR-0403) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
acagcccggcgcggtgcgcctgcccgcgact	Protospacer
 . *********** * *********  .**

26. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_CP026093 (Ralstonia solanacearum strain SFC plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ccagagcggcggggcgggcctgcccggcgtg	Protospacer
*. *  ***** ** **************.

27. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_CP021767 (Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
ccagagcggcggggcgggcctgcccggcgtg	Protospacer
*. *  ***** ** **************.

28. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NC_010392 (Phage Gifsy-1, complete genome) position: , mismatch: 8, identity: 0.742

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
acagcccggcgcggtgcgcctgcccgcgact	Protospacer
 . *********** * *********  .**

29. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 9, identity: 0.71

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
gccggccgacgcgggggccctgcccggccgg	Protospacer
 ..* ***.******** **********

30. spacer 4.1|2631332|31|NZ_CP013219|CRISPRCasFinder matches to NZ_CP020695 (Sulfitobacter sp. D7 plasmid p1SUD7, complete sequence) position: , mismatch: 10, identity: 0.677

cttgcccggcgcggggggcctgcccggcgct	CRISPR spacer
gcgcaacggcgcggggggcttgcccggccgc	Protospacer
 .    *************.********  .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

12785 : 64162

Gordonia_phage(50.0%)

integrase,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_058083625.1\|12785_14273_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_058078891.1\|14635_15589_+\|transposase	IS481 family transposase	NA	NA	NA	NA
WP_159103773.1\|16640_17018_+	hypothetical protein	NA	NA	NA	NA
WP_058078893.1\|17687_17960_-	DUF559 domain-containing protein	NA	NA	NA	NA
WP_058078894.1\|18056_18602_-	hypothetical protein	NA	NA	NA	NA
WP_159103774.1\|20136_20307_-	hypothetical protein	NA	NA	NA	NA
WP_058078895.1\|20955_23094_+	hypothetical protein	NA	NA	NA	NA
WP_159103775.1\|23090_23576_+	hypothetical protein	NA	NA	NA	NA
WP_159103776.1\|23701_23863_+	hypothetical protein	NA	NA	NA	NA
WP_058078897.1\|24508_24787_+	hypothetical protein	NA	NA	NA	NA
WP_159103777.1\|24798_25566_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_058078898.1\|25466_25790_+	hypothetical protein	NA	NA	NA	NA
WP_058078899.1\|26043_26610_-	hypothetical protein	NA	NA	NA	NA
WP_159103778.1\|26787_28086_-	protein kinase	NA	NA	NA	NA
WP_058078902.1\|28811_29732_-\|transposase	IS3 family transposase	Q6H9S6	Enterobacteria_phage	6.9e-46	40.2
WP_159103779.1\|29728_29992_-\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	3.7e-13	55.7
WP_159103780.1\|29923_30580_+	hypothetical protein	NA	NA	NA	NA
WP_159103781.1\|30679_31372_-	hypothetical protein	NA	NA	NA	NA
WP_107112966.1\|31653_32802_-	hypothetical protein	NA	NA	NA	NA
WP_159103782.1\|32993_33647_-	hypothetical protein	NA	NA	NA	NA
WP_058078906.1\|33957_34341_+	hypothetical protein	NA	NA	NA	NA
WP_058078907.1\|34588_34861_-	hypothetical protein	NA	NA	NA	NA
WP_058078908.1\|34845_38163_-	ATP-binding protein	NA	NA	NA	NA
WP_058083628.1\|38820_39561_-	hypothetical protein	NA	NA	NA	NA
WP_079087880.1\|40155_40947_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_058078909.1\|40903_41434_-	hypothetical protein	NA	NA	NA	NA
WP_058078910.1\|42948_43929_-	hypothetical protein	NA	NA	NA	NA
WP_058078903.1\|45821_46130_+\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	1.3e-17	52.0
WP_058078911.1\|46126_47047_+\|transposase	IS3 family transposase	A0A1P8CWQ3	Bacillus_phage	7.9e-34	33.3
WP_058078912.1\|47635_48406_+	GAF domain-containing protein	NA	NA	NA	NA
WP_058078913.1\|48402_48762_+	hypothetical protein	NA	NA	NA	NA
WP_159103783.1\|49085_49469_+	hypothetical protein	NA	NA	NA	NA
WP_079087883.1\|49351_49963_-	hypothetical protein	NA	NA	NA	NA
WP_058078915.1\|49928_50702_-	hypothetical protein	NA	NA	NA	NA
WP_159103784.1\|50698_51208_-	hypothetical protein	NA	NA	NA	NA
WP_063823242.1\|51236_51497_-	hypothetical protein	NA	NA	NA	NA
WP_079087884.1\|51544_58678_-	hypothetical protein	NA	NA	NA	NA
WP_058078917.1\|59262_62694_+	DNRLRE domain-containing protein	NA	NA	NA	NA
WP_058078918.1\|63070_64162_-\|transposase	IS630 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

745809 : 807606

Bacillus_phage(33.33%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_058079276.1\|745809_746763_-\|transposase	IS481 family transposase	NA	NA	NA	NA
WP_058079277.1\|746926_748258_-	MFS transporter	NA	NA	NA	NA
WP_058079278.1\|748341_748956_-	amino acid transporter	NA	NA	NA	NA
WP_058079279.1\|749022_749913_+	LysR family transcriptional regulator ArgP	NA	NA	NA	NA
WP_014670730.1\|750713_750965_+	WhiB family transcriptional regulator	A0A2P1JRB7	Mycobacterium_phage	1.1e-11	42.5
WP_058079280.1\|750985_751435_-	hypothetical protein	NA	NA	NA	NA
WP_058079281.1\|751525_753376_-	HAMP domain-containing protein	W8CYF6	Bacillus_phage	2.2e-27	32.7
WP_058079282.1\|753372_754080_-	response regulator transcription factor	W8CYM9	Bacillus_phage	6.7e-25	31.9
WP_058079283.1\|754100_754835_-	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_058079284.1\|754904_756314_-	M1 family metallopeptidase	NA	NA	NA	NA
WP_058079285.1\|756501_756837_+	DUF488 family protein	NA	NA	NA	NA
WP_058079286.1\|756839_758513_-	FAD-binding dehydrogenase	A0A2P0ZL82	Lactobacillus_phage	3.9e-07	32.4
WP_014670738.1\|758610_759231_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_058079287.1\|759346_759976_+	alpha-ketoglutarate-dependent dioxygenase AlkB	A0A1X6WG33	Pacmanvirus	9.5e-07	26.9
WP_058079288.1\|760057_760804_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_058079289.1\|761574_762810_+	DUF4032 domain-containing protein	NA	NA	NA	NA
WP_058079290.1\|762811_763678_-	universal stress protein	NA	NA	NA	NA
WP_014670743.1\|763674_763923_-	hypothetical protein	NA	NA	NA	NA
WP_014670744.1\|763938_765615_+	response regulator	G3MA85	Bacillus_virus	1.2e-32	29.7
WP_058079291.1\|765611_767063_+	cyclic nucleotide-binding domain-containing protein	NA	NA	NA	NA
WP_058079292.1\|767059_767410_+	UBP-type zinc finger domain-containing protein	NA	NA	NA	NA
WP_079087915.1\|768026_769790_-	M4 family metallopeptidase	NA	NA	NA	NA
WP_058083694.1\|771529_772858_-\|protease	serine protease	NA	NA	NA	NA
WP_058079294.1\|774130_775069_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015493185.1\|776069_776744_+	AIM24 family protein	NA	NA	NA	NA
WP_058079295.1\|776896_777937_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_058079296.1\|777933_778959_+	polyprenyl synthetase family protein	NA	NA	NA	NA
WP_058079297.1\|779050_780010_+	threonine/serine dehydratase	NA	NA	NA	NA
WP_058079298.1\|780163_781744_+	serine/threonine protein kinase	NA	NA	NA	NA
WP_058079299.1\|781794_782766_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_058079300.1\|782915_783419_+	hypothetical protein	NA	NA	NA	NA
WP_079088222.1\|783561_784641_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_058079301.1\|784687_785116_+	SsgA family sporulation/cell division regulator	NA	NA	NA	NA
WP_014670765.1\|785231_785840_+	DUF2238 domain-containing protein	NA	NA	NA	NA
WP_058079302.1\|785903_786398_-	hypothetical protein	NA	NA	NA	NA
WP_058079303.1\|786451_787435_-	aldo/keto reductase	NA	NA	NA	NA
WP_058079304.1\|787554_788184_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_058079305.1\|788180_789653_-	MFS transporter	NA	NA	NA	NA
WP_058083696.1\|789807_790488_-	lipase family protein	E5ERW5	Ostreococcus_lucimarinus_virus	3.5e-15	30.1
WP_058079306.1\|790963_792229_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_058079307.1\|792294_793497_-	FAD-binding monooxygenase	NA	NA	NA	NA
WP_079087917.1\|793648_793927_+	hypothetical protein	NA	NA	NA	NA
WP_079087918.1\|793851_794574_-	ribonuclease HI	A0A1D6Y7Z5	Golden_Marseillevirus	5.8e-16	35.4
WP_058079308.1\|794608_795403_-	VOC family protein	NA	NA	NA	NA
WP_058079309.1\|795522_796437_+	aminoglycoside phosphotransferase family protein	NA	NA	NA	NA
WP_014670775.1\|796459_796942_-	VOC family protein	NA	NA	NA	NA
WP_058079310.1\|797100_797514_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014670777.1\|797775_798666_+	RNA polymerase sigma factor SigF	A0A0A0RV91	Bacillus_phage	2.3e-22	32.3
WP_058079311.1\|798726_799206_-	ATP-binding protein	NA	NA	NA	NA
WP_058079312.1\|799358_799769_-	hypothetical protein	NA	NA	NA	NA
WP_058079313.1\|800133_800517_+	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_014670781.1\|800665_801658_-	L-glyceraldehyde 3-phosphate reductase	NA	NA	NA	NA
WP_014670782.1\|801769_802678_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_058083698.1\|802766_803267_+	DUF664 domain-containing protein	NA	NA	NA	NA
WP_058079276.1\|803622_804576_+\|transposase	IS481 family transposase	NA	NA	NA	NA
WP_058079314.1\|804572_805652_-	adenosine deaminase	NA	NA	NA	NA
WP_014670785.1\|805699_806089_-	VOC family protein	NA	NA	NA	NA
WP_058079315.1\|806676_807606_-\|protease	M48 family metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_3

1009332 : 1063859

Bacillus_phage(33.33%)

transposase,tail,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_058079445.1\|1009332_1012146_+\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_058079446.1\|1014764_1017536_+	SpoIIE family protein phosphatase	A0A1J0MCT1	Streptomyces_phage	2.6e-08	47.6
WP_058079447.1\|1017657_1017990_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_014671002.1\|1018242_1018986_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_058079448.1\|1019138_1023884_+	type IV secretion protein Rhs	A0A2H4JFP5	uncultured_Caudovirales_phage	1.3e-18	39.8
WP_014671004.1\|1023908_1024457_+	hypothetical protein	NA	NA	NA	NA
WP_058079449.1\|1024544_1025012_-	hypothetical protein	NA	NA	NA	NA
WP_058079451.1\|1025774_1027109_-	diaminopimelate decarboxylase	NA	NA	NA	NA
WP_058079452.1\|1027123_1027492_-	hypothetical protein	NA	NA	NA	NA
WP_058079453.1\|1027796_1028360_+	universal stress protein	NA	NA	NA	NA
WP_014671010.1\|1029159_1029843_-	response regulator transcription factor	W8CYM9	Bacillus_phage	7.9e-23	31.1
WP_058079455.1\|1029982_1030663_-	potassium-transporting ATPase subunit C	NA	NA	NA	NA
WP_058079456.1\|1030674_1032771_-	potassium-transporting ATPase subunit KdpB	M1HBF8	Paramecium_bursaria_Chlorella_virus	1.1e-27	23.5
WP_058079457.1\|1032803_1034465_-	potassium-transporting ATPase subunit KdpA	NA	NA	NA	NA
WP_016434100.1\|1034472_1034562_-	K(+)-transporting ATPase subunit F	NA	NA	NA	NA
WP_058079458.1\|1034558_1034906_-	hypothetical protein	NA	NA	NA	NA
WP_058079459.1\|1035073_1035457_+	hypothetical protein	NA	NA	NA	NA
WP_058079460.1\|1035374_1037873_-	sensor histidine kinase KdpD	NA	NA	NA	NA
WP_058079461.1\|1038547_1040500_+	APC family permease	NA	NA	NA	NA
WP_058079462.1\|1041151_1041985_+	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_058079463.1\|1042095_1043409_-	hypothetical protein	NA	NA	NA	NA
WP_079087928.1\|1043710_1044349_+	response regulator transcription factor	NA	NA	NA	NA
WP_058079465.1\|1044626_1046720_+	VWA domain-containing protein	NA	NA	NA	NA
WP_058079466.1\|1046729_1047425_+	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_058079467.1\|1047421_1049542_+	ATP-binding protein	A0A2D2W2C3	Stenotrophomonas_phage	1.9e-06	28.2
WP_058079468.1\|1051024_1051792_-\|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
WP_058079469.1\|1051864_1052248_+	hypothetical protein	NA	NA	NA	NA
WP_058083714.1\|1052854_1053250_+	hypothetical protein	NA	NA	NA	NA
WP_107112812.1\|1053265_1054146_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_079087932.1\|1054322_1055552_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_107112813.1\|1057901_1061294_-	hypothetical protein	NA	NA	NA	NA
WP_058079472.1\|1061799_1063365_+\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	7.3e-72	34.0
WP_014671025.1\|1063415_1063859_+\|tail	phage tail protein	NA	NA	NA	NA

DBSCAN-SWA_4

8584304 : 8621439

Bacillus_phage(50.0%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_058083590.1\|8584304_8585456_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_159103870.1\|8586354_8586828_+	hypothetical protein	NA	NA	NA	NA
WP_058083593.1\|8587502_8588810_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_058083595.1\|8589338_8589662_+	hypothetical protein	NA	NA	NA	NA
WP_058084234.1\|8592428_8593391_-	hypothetical protein	M1H502	Paramecium_bursaria_Chlorella_virus	5.5e-46	36.8
WP_159103871.1\|8594274_8594505_+	hypothetical protein	NA	NA	NA	NA
WP_058083597.1\|8594518_8595685_-	peptidoglycan bridge formation glycyltransferase FemA/FemB family protein	NA	NA	NA	NA
WP_079088206.1\|8595773_8596829_-	hypothetical protein	NA	NA	NA	NA
WP_058083598.1\|8597621_8598314_+	response regulator transcription factor	W8CYM9	Bacillus_phage	3.1e-19	29.1
WP_058084236.1\|8598306_8599440_+	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_058083599.1\|8600067_8601450_-	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	NA	NA	NA	NA
WP_058083600.1\|8602162_8603203_+	D-alanine--(R)-lactate ligase	NA	NA	NA	NA
WP_058083601.1\|8603199_8603808_+	D-Ala-D-Ala dipeptidase VanX	NA	NA	NA	NA
WP_159103872.1\|8603779_8604451_+	hypothetical protein	NA	NA	NA	NA
WP_058083944.1\|8606990_8607497_+	hypothetical protein	NA	NA	NA	NA
WP_107112877.1\|8607438_8608245_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_058083603.1\|8608529_8609879_-\|protease	trypsin-like serine protease	NA	NA	NA	NA
WP_058084237.1\|8609993_8610299_-	hypothetical protein	NA	NA	NA	NA
WP_159103873.1\|8610371_8610515_-	hypothetical protein	NA	NA	NA	NA
WP_159103874.1\|8611235_8612387_-	hypothetical protein	NA	NA	NA	NA
WP_107112961.1\|8612434_8613644_+\|transposase	IS3 family transposase	A0A1P8CWQ3	Bacillus_phage	4.8e-31	34.7
WP_063823273.1\|8613738_8614311_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_079088301.1\|8614927_8615269_+	DUF4440 domain-containing protein	NA	NA	NA	NA
WP_058083608.1\|8616089_8616992_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_058083609.1\|8617595_8618159_+	DinB family protein	NA	NA	NA	NA
WP_107113022.1\|8618420_8619902_+\|transposase	transposase	NA	NA	NA	NA
WP_079088209.1\|8620005_8621439_+\|transposase	IS1380 family transposase	A0A222ZN33	Mycobacterium_phage	5.2e-93	47.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP013220

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP013219

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection