CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP013610	Lactobacillus delbrueckii subsp. bulgaricus strain MN-BM-F01 chromosome, complete genome	3 crisprs	cas3,DEDDh,cas9,cas1,cas2,csn2,DinG,csa3,Cas14u_CAS-V,c2c9_V-U4,cas14j,WYL	0	9	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP013610_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013610_1

499640-499729

Orphan

Consensus_repeat	Method
TAGAGCGAGTAAGACTTACACAAGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013610_1

>merge|NZ_CP013610|1|499640-499729|CRISPRCasFinder
TAGAGCGAGTAAGACTTACACAAGACTACACAAGACTACACAAGACTAAAAAGCCTGCTTAGCCTTAGAGCGAGTAGGACTTACACAAGA

>NZ_CP013610|1|1|499640-499729|CRISPRCasFinder
TAGAGCGAGTAAGACTTACACAAGA	CTACACAAGACTACACAAGACTAAAAAGCCTGCTTAGCCT
TAGAGCGAGTAGGACTTACACAAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013610.1\|WP_060597895.1\|499959_500205_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013610.1\|WP_002877046.1\|491559_491748_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013610.1\|WP_060597890.1\|495158_496112_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP013610.1\|WP_060597900.1\|505034_507353_+\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|224588
NZ_CP013610.1\|WP_003618885.1\|502848_503985_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP013610.1\|WP_003622651.1\|491819_492647_-\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|234712
NZ_CP013610.1\|WP_060597897.1\|500553_500904_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013610.1\|WP_081044821.1\|493806_494949_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP013610.1\|WP_002877037.1\|504619_505015_+\|DUF1149-family-protein	unknown	unknown	gnl\|CDD\|369003
NZ_CP013610.1\|WP_003622668.1\|504030_504588_+\|tRNA-(cytidine(34)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|349967
NZ_CP013610.1\|WP_060597899.1\|501417_501882_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013610.1\|WP_003622648.1\|490580_491474_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP013610.1\|WP_060597898.1\|500908_501352_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013610.1\|WP_011543720.1\|502458_502839_+\|PTS-glucitol/sorbitol-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|367683
NZ_CP013610.1\|WP_060598259.1\|496485_496803_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013610.1\|WP_060597891.1\|496291_496486_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP013610.1\|WP_060597893.1\|497288_498152_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214926
NZ_CP013610.1\|WP_060597892.1\|496974_497292_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013610.1\|WP_060597896.1\|500223_500541_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013610.1\|WP_060597889.1\|492669_493680_-\|lactonase-family-protein	unknown	unknown	gnl\|CDD\|378416

Protein	Function_ID	Function_description	E-value
NZ_CP013610.1\|WP_060597890.1\|495158_496112_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.85972e-11
NZ_CP013610.1\|WP_003622651.1\|491819_492647_-\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|234712	PRK00281, PRK00281, undecaprenyl-diphosphate phosphatase.	1.70758e-106
NZ_CP013610.1\|WP_081044821.1\|493806_494949_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	7.36996e-51
NZ_CP013610.1\|WP_002877037.1\|504619_505015_+\|DUF1149-family-protein	gnl\|CDD\|369003	pfam06619, DUF1149, Protein of unknown function (DUF1149). This family consists of several hypothetical bacterial proteins of unknown function.	7.8976e-37
NZ_CP013610.1\|WP_003622668.1\|504030_504588_+\|tRNA-(cytidine(34)-2'-O)-methyltransferase	gnl\|CDD\|349967	cd18094, SpoU-like_TrmL, SAM-dependent tRNA methylase related to TrmL. tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	1.2921e-80
NZ_CP013610.1\|WP_011543720.1\|502458_502839_+\|PTS-glucitol/sorbitol-transporter-subunit-IIA	gnl\|CDD\|367683	pfam03829, PTSIIA_gutA, PTS system glucitol/sorbitol-specific IIA component.	8.39384e-38
NZ_CP013610.1\|WP_003622648.1\|490580_491474_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	2.24655e-76
NZ_CP013610.1\|WP_060597900.1\|505034_507353_+\|DNA-translocase-FtsK	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	4.65437e-169
NZ_CP013610.1\|WP_003618885.1\|502848_503985_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	1.56202e-62
NZ_CP013610.1\|WP_060597891.1\|496291_496486_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	7.38094e-05
NZ_CP013610.1\|WP_060597893.1\|497288_498152_+\|hypothetical-protein	gnl\|CDD\|214926	smart00942, PriCT_1, Primase C terminal 1 (PriCT-1). This alpha helical domain is found at the C terminal of primases.	9.05454e-13
NZ_CP013610.1\|WP_060597889.1\|492669_493680_-\|lactonase-family-protein	gnl\|CDD\|378416	pfam10282, Lactonase, Lactonase, 7-bladed beta-propeller. This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyze 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.	5.1637e-137

>NZ_CP013610.1|WP_060597893.1|497288_498152_+|hypothetical-protein
MSVYIEQGLTSKNMFESDYGLEECLLRAGASPAVNITEENCDRIKATQGYYAISGEMVKLEHETENIVSRDALALDLDDVSPQIANFDDLEDEIRGVLKGTWYLYPTAKNGLRGTRARLIIPLDTPANKEQYEALAYGLTSYLIKQGVLTGADESSFRFGQLFGLPIRNQFSKGDLVRINRGKLLSTESYTAFKKPEKPSRAGDYPARSGGQSYGASLLDRIFNGIPNGQRNNSMFELACYYVKIGVQNQASLLDYLRLINSNYFSPPLGDDELIRVFESARKKVLN
>NZ_CP013610.1|WP_060597892.1|496974_497292_+|hypothetical-protein
MNINKLTKQEEQVLACLPKGEKNAKKVKTIVLQSGCDARELHVIKQSLLKKGVAIGSSRHKPYGWFIPANKEEAKRGLLEYSSQAATMNKTVARFKAAIQEEFGQ
>NZ_CP013610.1|WP_060598259.1|496485_496803_+|hypothetical-protein
MLDQEQEQEIKKYLFNLVKESFEGMHLEPESRPYLNRNQIAAFFGVSPNTIDIWVRAGAPVAVVEGRKFYGKESLTNWLKQHEEPKESTKKTVSGQTEKSTLTVL
>NZ_CP013610.1|WP_060597891.1|496291_496486_+|helix-turn-helix-domain-containing-protein
MSEYLSKRQAMEYLGLAPTSYRSIDQYIKEGLPVFVIGNKPRFSKKSIDTFMDKHKRGGEVSCK
>NZ_CP013610.1|WP_060597890.1|495158_496112_-|helix-turn-helix-domain-containing-protein
MTNRIKQLRKENGLTLKELSREVGIPASTISQYENERRKIPESASKILSTFFEVPENYILGAWSKKEVLELMSSSLKANYDRIYKMAIEYGGDGEEWRLLDEISVDGGDQIYITGSGQVMKFNESALSSTPSKKKFIDELRRNYFEGLAFAVLKFVYYRGVCHNFHTEEHFDYEARIEADDKLTDAEKKIRLNYKSYPEIKGHENVHRFMMNFWRKRNSAKRLAFLDAFFHEYDDNSILEDAVVNKIMQEKVPAETMALVLTSVINSATNSFGIAVRSENELYIISRLEQQYNELSNEFDELQKENDRLKAELASKR
>NZ_CP013610.1|WP_081044821.1|493806_494949_-|site-specific-integrase
MNKKDIIKYQTASGKDRYKFIVYAGKDETTGKSIIVRKQGFKTLKEAKQAYLDVQQAILDGDYLPINQKRLTYKGLLELYLPLYAQTVKETSFYQFKRCMELQVLPVLGDVYLDKITPQLCQKAVNQWAKDTPGGFVRVAAWSSRVLKYAFQIGLIDSNPFDRVIKPKKPAKKKKDNFYTKDELETFLNGARDAGMMKYTLFRLLAFSGMRIGELIALEWSDVDFFRKTVSINKTLTLDKGGKSTIGSPKTASGNRTIMLDDATMNALQKWRAEQSRRIIYLGKPKNDLVFPSEHGSYLVNSVIQYWNEKIAEKQGLRKISLHGFRHTHASLCFEAGLTMQDVKERLGHSNISTTMDIYTHVTKSRKEESIQQLAKFMRA
>NZ_CP013610.1|WP_060597889.1|492669_493680_-|lactonase-family-protein
MHILIGGYTKHESAGIYQFDFIGSGDQAHLEQRRNVVEVGGPTYFQKDGQFIFTIKNENGQGGIAAFANGKLVSQLLHEGSSPAYIGINKEKKLLYTANYHTGVLAVISYDDQGQLTLLDQVKHENKALGPRPEQAGAHPHYFDETPGGHLVSCDLGQDRVDFYGFDGQKLTHLASYQNKDGFGSRHLAFSPDGKYFYVAGELSSQVNVVKFDEENWMFRSLATYSTIPESWDQHNGAAAIRLSSDGKFLYVSNRGHDSIAVFAVLPDQALKLVQRVSTFGEFPRDFNWDAEEKYVVAANQNSNNATLYQRQSDGTLTPLEKDIAVPEGTRVLFTD
>NZ_CP013610.1|WP_003622651.1|491819_492647_-|undecaprenyl-diphosphate-phosphatase
MLDIFKAIILGIIEGVTEFLPISSTGHLYLADYIIKLDQPTSFINMFMVVIQLGAILSVIVIYFNKLNPFAPSKSKREKGQTWQIWFKVIAAVLPSIIIGLPLNDWLEENMTSWQVISATLIIYGILFIVLENYYAKRQPSLTDLNKMSNKTALLIGCFQVLSMIPGTSRSGATILGAMLIGSSRYVATEFSFFLAIPTMFGASLLKLVKFFKAGHVFVGNQLAILLVGMVVSFIVAYLSIKFLLKYVQTHDFKPFGWYRIVLGIIVTICGLVFA
>NZ_CP013610.1|WP_002877046.1|491559_491748_-|hypothetical-protein
MLSLLCLLFILWLCWKMGVALWRVLIFLIGVGLAFALLSSVVLPLLAICALGGLAWAVISNA
>NZ_CP013610.1|WP_003622648.1|490580_491474_+|RluA-family-pseudouridine-synthase
MIVAKNDPGQLSHFLLKKGFSRRAVNNCKNHGGMMLVNHHRRNGSYRLKEGDVVHFLMGQEPVNPWLKVSRRPLDIVEETADYLVINKPAGLLSIPSGFHAEDAVINRVLAYFEKQGVNPAYVKPHIVTRLDQDTSGLVLLGKNAIAHDRFSKLGKDAFIKKYHAIVHGNFAEGDLSGLIDKPLARVGDTVKREVNPKGQRALTEYRVLNQVPGASLVELRLLTGRTHQIRIHMASIGHVLYGDDLYGARDAFARQALNCFYLAFPNPFSGEEREIEIPDPGDMQGLWRQLKQEAGK
>NZ_CP013610.1|WP_060597895.1|499959_500205_+|hypothetical-protein
MTTKEEIKLEEQYSEKYKTLQNLVAMVEDQYSGSFIITPAGEQIPEPHGWTLVEISKLALEMYGLTTALDQDNKTALYIDC
>NZ_CP013610.1|WP_060597896.1|500223_500541_+|hypothetical-protein
MTKQSNEPTKRASKKDPAMNNTTKASYLLSERNRYLLEVVAMFKKEHRYPGRDADPVELDQAAAQFNARHREEISPKLEKAEQYEKAFVSYASPEELAQAEILFN
>NZ_CP013610.1|WP_060597897.1|500553_500904_+|hypothetical-protein
MTKQLTLEKVQEAQALFEKLENDLAILLQDKEEQIKADLSGQRDALSEAYDEARDDFQLSSECLLEAPASDRPGPEDFLQAGRLLIDLAIVAAQLDELDQEEQAFYQLKKKAVKEG
>NZ_CP013610.1|WP_060597898.1|500908_501352_+|hypothetical-protein
MKKSKKQAAIKKWSVIVEEMQVLRDVSGEELTHSLNMRKLASQHDQKAEKISASMDNMETRGILGNVDQAFQELKDEAEKLTSLSDQFERENILSRSYEAEANYHIRRLIERWSNFSLEEFLSLPGADPAMYNQFEARINLLAKLIN
>NZ_CP013610.1|WP_060597899.1|501417_501882_+|hypothetical-protein
MPRIVERTPLPPAGPATDTEALLCFLELCSITAIKPSFPIDEQELAATVNATRESARASLYLFSAQYLLCINDAIAGIPTEVERFRGYRDPQKLIIAKYIERKPVYEFQEENSLQSTKFRRLQRIGLKSFTENFNQAIIKRGFNLAPIESTCKA
>NZ_CP013610.1|WP_011543720.1|502458_502839_+|PTS-glucitol/sorbitol-transporter-subunit-IIA
MKWISTIKAIGPNAISEKDRVVILFGQTAKDELQDVSVIQTFDDEQAAQAVVLKKGDTVTIDGTTFLINYVGPMAVSNLRALQHASLFFTDKVPKKPMSNALYLDLPEDQEMPKFRVDDKIVYEHL
>NZ_CP013610.1|WP_003618885.1|502848_503985_+|AI-2E-family-transporter
MKKRDTSLFTDWVLNNRFSVGLINVLLVLVIVLVFNKISFILNPVNTFISAILPPLLVAMVQYYLMEPVVDKLEEKFKVPRTVTIMVIFAIVTVFLIWAINSLIPVVQSQIDSLVKNWPTIWKNSTNAVDELLHSPKFSGLRDSLQKQMTSLQKNFSKSMGSTVSSALGNLTSAVTVATAVFTTLATAPFLLFFMLKDGHKLRPFLVKFAPQRWEQATSKLLHEVNQAVSSYVIGQVSVAICVGIMFFIGYTIIGEPYGAALAICAGFLNLIPYFGAFIGLIPALIIALVTDLPMVAKVLVVFFIEQIIETRVISPLVVGNRLKMHPATTIIVMLGAGSVWGLWGVIGGIPIYAVMKILLTHVYRYYRKVSHLYDDSF
>NZ_CP013610.1|WP_003622668.1|504030_504588_+|tRNA-(cytidine(34)-2'-O)-methyltransferase
MTNHIVLFEPEIPDNTGNIARTCAGTNTVLDLIEPLGFRLDDKHLKRAVLDYGGEVEIRRHDDLRAFLATLPDNAEMYLISKFSSKVYTDVDYTDESKDYYFVFGRETTGLPETFMRQYADRNLRIPMSDKIRAFNLSNSAAIVIFEALRQQGFPHMEKSHHYENDKLKDDYNRPGRYQRNLPKH
>NZ_CP013610.1|WP_002877037.1|504619_505015_+|DUF1149-family-protein
MEFNKQTPIIVRAFHYDLLDEPEEKNEVNVAIRQVVATGEDGVEDAGEAGGYYEVAVVYDVTPDEDNIIEISGVNTQVVQLLGYHGDGQDLDQETYRLLSRPLVEYIETLTYEVSQVALDEPINLDFEPNF
>NZ_CP013610.1|WP_060597900.1|505034_507353_+|DNA-translocase-FtsK
MPRKKRQANRKNKNKKKTEESLSWVVTGIVSILVAILALLRFGWLGKELANLLRLLIGDSYLLGGAFLAILGLVMLIYGQPPRFGFKRTSGLILAYLGLLYILASRFFNVRSVHSEFLTAFKNVIFEELARANVTVSVGGGWIGSFLYGILYQLLGQIGGLCLAVLNIISGILMFFDVKFRSLVAAFQKISRSFIQQSKDGAGQLKEKYSEYREQQRKDPNNREKLTDPWRDSEEAKPSLPEIQVAEQHPDPPVTNSLELDDLLKPRSQAEDDQKMILADQQVDHGLDKSTVSYDDNYQFPPLSLLKAVQASDQSSDKDKTRQNTAILEETFKSFGVEVNVKRAILGPTITRYEVQPAVGVKVSRIVNLADDLALALAAKDIRIEAPIPGKPYIGIEVPNQKAQSVAFKDAMEHQDQKAKDHPLMVPLGKDVTGQIISADLTKMPHLLVAGSTGSGKSVAINTILTSILMKARPDEVKLVLIDPKMVELSVYSGVPHLMIPVVTDSRLASKALKKVVDEMERRYKLFAAGSVRNMGEYNRKVAENNKDTSRPVMEPLPYILVVVDELSDLMMVGGHDVENSIVRLGQMARAAGIHMILATQRPSVDVITGLIKANVPSRISFAVSSGVDSRTILDQVGAEKLLGRGDMLYLPIGASKPDRIQGGYIDVDEVEAVVDWVKGQQSAEYDEEMIPQAGDDDESSDDDVDDEYYQQAVDLVRRQQSASTSMLQRRFRIGYNRAARLIDELEEHGVVGPPEGSKPRKVLLPPEGQEE

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Crispr_ID: NZ_CP013610_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013610_2

767269-768625

TypeII

Consensus_repeat	Method
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	PILER-CR
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CRISPRCasFinder
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CRT

20 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_CP013610_2

>merge|NZ_CP013610|2|767269-768625|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCGTTGCCACCGCATTTTCTGGCTTTTTGTAGGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCGTAAGTTTACTTTGGTTGATGCAGCTAATGGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCAACTGACAGCAGTGTAGACCGAATTCGTGAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCGGCTTTTGCCTTGCACGACTTTTGCCTGCAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCGTGTCGTCGTCAGATAATCTACATCCTGTGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCAGACTCATTGTCAAGACCTTACAGAAGTTGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCATTTGTCAAGGAGTACGGCTGGCGGATTGAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCATACATACCGGCCCTTTGCGCCGTCAACATGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCGCTGCCATGGCGTCAATCGGCCGGGTGTTAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCACTTGCCTCCCCTTTTTAAGCCAGCCCCTGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCATTTAATAACGCCTGTAATCTTGCCCTCTTGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCGTATATCTGGCGCTGATAGTCACAGTAGTCGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCTGCCGGCAGTTGACCAAGCCTTATAAGGTAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCAATAACTGTGTGATTTTAATCGGAAGACTGGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCATATCCGTGCGCTCAGCCTCATGGACAGCGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCAAATTTAAGCCAAATGCTGATACCAGCACGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCCGTTTTCCGTCACATGATACTCCGGCATCGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCATATGGATTCAATTTGAACACTCAAACATTGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCACAAATATCGCGGTTTTGATCGGTCGTCCGAGTTTTAGAAGGTTGTCTATTCAGTAAGGTTTAACCCCAACCGACATCACTGTTGCTCAAGGCGCAGGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCG

>NZ_CP013610|2|1|767269-768559|PILER-CR
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTTGCCACCGCATTTTCTGGCTTTTTGTAG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTAAGTTTACTTTGGTTGATGCAGCTAATG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AACTGACAGCAGTGTAGACCGAATTCGTGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GGCTTTTGCCTTGCACGACTTTTGCCTGCA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CGTGTCGTCGTCAGATAATCTACATCCTGT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CAGACTCATTGTCAAGACCTTACAGAAGTT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ATTTGTCAAGGAGTACGGCTGGCGGATTGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ATACATACCGGCCCTTTGCGCCGTCAACAT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GCTGCCATGGCGTCAATCGGCCGGGTGTTA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CACTTGCCTCCCCTTTTTAAGCCAGCCCCT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ATTTAATAACGCCTGTAATCTTGCCCTCTT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTATATCTGGCGCTGATAGTCACAGTAGTC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TGCCGGCAGTTGACCAAGCCTTATAAGGTA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AATAACTGTGTGATTTTAATCGGAAGACTG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CATATCCGTGCGCTCAGCCTCATGGACAGC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CAAATTTAAGCCAAATGCTGATACCAGCAC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CCGTTTTCCGTCACATGATACTCCGGCATC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ATATGGATTCAATTTGAACACTCAAACATT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACAAATATCGCGGTTTTGATCGGTCGTCCGA
GTTTTAGAAGGTTGTCTATTCAGTAAGGTTTAACCC

>NZ_CP013610|2|2|767269-768625|CRISPRCasFinder
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTTGCCACCGCATTTTCTGGCTTTTTGTAG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTAAGTTTACTTTGGTTGATGCAGCTAATG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AACTGACAGCAGTGTAGACCGAATTCGTGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GGCTTTTGCCTTGCACGACTTTTGCCTGCA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CGTGTCGTCGTCAGATAATCTACATCCTGT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CAGACTCATTGTCAAGACCTTACAGAAGTT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ATTTGTCAAGGAGTACGGCTGGCGGATTGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ATACATACCGGCCCTTTGCGCCGTCAACAT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GCTGCCATGGCGTCAATCGGCCGGGTGTTA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CACTTGCCTCCCCTTTTTAAGCCAGCCCCT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ATTTAATAACGCCTGTAATCTTGCCCTCTT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTATATCTGGCGCTGATAGTCACAGTAGTC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TGCCGGCAGTTGACCAAGCCTTATAAGGTA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AATAACTGTGTGATTTTAATCGGAAGACTG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CATATCCGTGCGCTCAGCCTCATGGACAGC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CAAATTTAAGCCAAATGCTGATACCAGCAC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CCGTTTTCCGTCACATGATACTCCGGCATC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ATATGGATTCAATTTGAACACTCAAACATT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACAAATATCGCGGTTTTGATCGGTCGTCCGA
GTTTTAGAAGGTTGTCTATTCAGTAAGGTTTAACCC	CAACCGACATCACTGTTGCTCAAGGCGCAG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCG

>NZ_CP013610|2|1|767269-768625|CRT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTTGCCACCGCATTTTCTGGCTTTTTGTAG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTAAGTTTACTTTGGTTGATGCAGCTAATG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AACTGACAGCAGTGTAGACCGAATTCGTGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GGCTTTTGCCTTGCACGACTTTTGCCTGCA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CGTGTCGTCGTCAGATAATCTACATCCTGT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CAGACTCATTGTCAAGACCTTACAGAAGTT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ATTTGTCAAGGAGTACGGCTGGCGGATTGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ATACATACCGGCCCTTTGCGCCGTCAACAT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GCTGCCATGGCGTCAATCGGCCGGGTGTTA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CACTTGCCTCCCCTTTTTAAGCCAGCCCCT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ATTTAATAACGCCTGTAATCTTGCCCTCTT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTATATCTGGCGCTGATAGTCACAGTAGTC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TGCCGGCAGTTGACCAAGCCTTATAAGGTA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AATAACTGTGTGATTTTAATCGGAAGACTG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CATATCCGTGCGCTCAGCCTCATGGACAGC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CAAATTTAAGCCAAATGCTGATACCAGCAC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CCGTTTTCCGTCACATGATACTCCGGCATC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ATATGGATTCAATTTGAACACTCAAACATT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACAAATATCGCGGTTTTGATCGGTCGTCCGA
GTTTTAGAAGGTTGTCTATTCAGTAAGGTTTAACCC	CAACCGACATCACTGTTGCTCAAGGCGCAG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013610.1\|WP_060597960.1\|765377_766289_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NZ_CP013610.1\|WP_003619897.1\|774056_774563_-\|aminoacyl-tRNA-deacylase	unknown	unknown	gnl\|CDD\|237976
NZ_CP013610.1\|WP_035162685.1\|766266_766572_+\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
NZ_CP013610.1\|WP_060597955.1\|756871_757096_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379188
NZ_CP013610.1\|WP_011543818.1\|756328_756532_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013610.1\|WP_060597962.1\|768980_770081_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_CP013610.1\|WP_060597963.1\|770082_771309_+\|hydroxymethylglutaryl-CoA-reductase,-degradative	unknown	unknown	gnl\|CDD\|153082
NZ_CP013610.1\|WP_060597956.1\|757548_757995_+\|FMN-binding-protein	unknown	unknown	gnl\|CDD\|226484
NZ_CP013610.1\|WP_003619905.1\|778018_778456_+\|D-tyrosyl-tRNA(Tyr)-deacylase	unknown	unknown	gnl\|CDD\|235383
NZ_CP013610.1\|WP_060597966.1\|775728_777990_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NZ_CP013610.1\|WP_003619893.1\|771312_772476_+\|hydroxymethylglutaryl-CoA-synthase	unknown	unknown	gnl\|CDD\|213655
NZ_CP013610.1\|WP_060597958.1\|758806_759475_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP013610.1\|WP_060598264.1\|760896_765159_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	mkCas0193_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|374653
NZ_CP013610.1\|WP_060597961.1\|766568_767237_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
NZ_CP013610.1\|WP_060597959.1\|759477_760737_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP013610.1\|WP_060597965.1\|774643_775588_+\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|234786
NZ_CP013610.1\|WP_003624319.1\|778739_780026_+\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|273080
NZ_CP013610.1\|WP_060597964.1\|772640_773999_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NZ_CP013610.1\|WP_060597967.1\|780041_781886_+\|aspartate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234775
NZ_CP013610.1\|WP_060597957.1\|758195_758810_+\|GTP-pyrophosphokinase	unknown	unknown	gnl\|CDD\|225232

Protein	Function_ID	Function_description	E-value
NZ_CP013610.1\|WP_060597960.1\|765377_766289_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	7.94292e-95
NZ_CP013610.1\|WP_003619897.1\|774056_774563_-\|aminoacyl-tRNA-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	1.02683e-65
NZ_CP013610.1\|WP_035162685.1\|766266_766572_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	3.0201e-28
NZ_CP013610.1\|WP_060597955.1\|756871_757096_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	0.000566178
NZ_CP013610.1\|WP_060597962.1\|768980_770081_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.91126e-162
NZ_CP013610.1\|WP_060597963.1\|770082_771309_+\|hydroxymethylglutaryl-CoA-reductase,-degradative	gnl\|CDD\|153082	cd00644, HMG-CoA_reductase_classII, Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR). Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR), class II, prokaryotic enzyme is a homodimer. Class II enzymes are found primarily in prokaryotes and Archaeoglobus fulgidus and are soluble as they lack the membrane region. Enzymes catalyze the synthesis of coenzyme A and mevalonate in isoprenoid synthesis. Bacteria, such as Pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3-hydroxy-3-methylglutaryl-CoA. Human and bacterial HMGR differ in their active site architecture.	0
NZ_CP013610.1\|WP_060597956.1\|757548_757995_+\|FMN-binding-protein	gnl\|CDD\|226484	COG3976, COG3976, Uncharacterized protein conserved in bacteria [Function unknown].	1.46378e-11
NZ_CP013610.1\|WP_003619905.1\|778018_778456_+\|D-tyrosyl-tRNA(Tyr)-deacylase	gnl\|CDD\|235383	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional.	3.03729e-86
NZ_CP013610.1\|WP_060597966.1\|775728_777990_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NZ_CP013610.1\|WP_003619893.1\|771312_772476_+\|hydroxymethylglutaryl-CoA-synthase	gnl\|CDD\|213655	TIGR01835, 3-hydroxy-3-methylglutaryl_CoA_synthase, 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade. This clade of hydroxymethylglutaryl-CoA (HMG-CoA) synthases is found in a limited spectrum of mostly gram-positive bacteria which make isopentenyl pyrophosphate (IPP) via the mevalonate pathway. This pathway is found primarily in eukaryotes and archaea, but the bacterial homologs are distinct, having aparrently diverged after being laterally transferred from an early eukaryote. HMG-CoA synthase is the first step in the pathway and joins acetyl-CoA with acetoacetyl-CoA with the release of one molecule of CoA. The Borellia sequence may have resulted from a separate lateral transfer event.	9.16099e-131
NZ_CP013610.1\|WP_060597958.1\|758806_759475_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.51734e-66
NZ_CP013610.1\|WP_060598264.1\|760896_765159_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|374653	pfam16592, Cas9_REC, REC lobe of CRISPR-associated endonuclease Cas9. The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defense against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.	5.82324e-124
NZ_CP013610.1\|WP_060597961.1\|766568_767237_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	1.63723e-68
NZ_CP013610.1\|WP_060597959.1\|759477_760737_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.77881e-28
NZ_CP013610.1\|WP_060597965.1\|774643_775588_+\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|234786	PRK00517, prmA, 50S ribosomal protein L11 methyltransferase.	4.37885e-91
NZ_CP013610.1\|WP_003624319.1\|778739_780026_+\|histidine--tRNA-ligase	gnl\|CDD\|273080	TIGR00442, hisS, histidyl-tRNA synthetase. This model finds a histidyl-tRNA synthetase in every completed genome. Apparent second copies from Bacillus subtilis, Synechocystis sp., and Aquifex aeolicus are slightly shorter, more closely related to each other than to other hisS proteins, and actually serve as regulatory subunits for an enzyme of histidine biosynthesis. They were excluded from the seed alignment and score much lower than do single copy histidyl-tRNA synthetases of other genomes not included in the seed alignment. These putative second copies of HisS score below the trusted cutoff. The regulatory protein kinase GCN2 of Saccharomyces cerevisiae (YDR283c), and related proteins from other species designated eIF-2 alpha kinase, have a domain closely related to histidyl-tRNA synthetase that may serve to detect and respond to uncharged tRNA(his), an indicator of amino acid starvation; these regulatory proteins are not orthologous and so score below the noise cutoff. [Protein synthesis, tRNA aminoacylation].	0
NZ_CP013610.1\|WP_060597964.1\|772640_773999_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	1.1106e-63
NZ_CP013610.1\|WP_060597967.1\|780041_781886_+\|aspartate--tRNA-ligase	gnl\|CDD\|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NZ_CP013610.1\|WP_060597957.1\|758195_758810_+\|GTP-pyrophosphokinase	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	5.33792e-64

>NZ_CP013610.1|WP_060597961.1|766568_767237_+|type-II-A-CRISPR-associated-protein-Csn2
MIITYKAHKSFEIENGKVNVIATSSPIAYCNLIEGMQEKNELLCAVSEDYDAIPLSKAVDWLGDPLISESLLQKYMTKLTSYVVDELSADGRNRIITFYRDLLNAVQDELLMEDLPLEISFDTDLKKLFKFGGLHFNKTLTHDPYGIIETVLRIHDRLDLKSTVVFSNVAHYLDVEQFIEISKLCLELKKSIIFIEFCSHKDQVVYGDAKFSYIDEDLVDWY
>NZ_CP013610.1|WP_035162685.1|766266_766572_+|CRISPR-associated-endonuclease-Cas2
MRLMIMFDLPVDTAVDRKQYRQFRKNLINEGFVMIQYSVYVRVCASKKAAELLEKRIRGYVPEYGVIQSLMLTEKQYNDMHFLLGEPVKDIRNTSDRTVIL
>NZ_CP013610.1|WP_060597960.1|765377_766289_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRNVIITQHSKLSYSSNMMVVHTKDGVSQIPVSDINMLVVLTTQAVITSALIAELAKKQTKVIFVDEKQEPICETENYYSTNCHPEKLIKQFNWDEDRKQILWTKIVAAKIQNQMNVLRIYGLPTDEIEKDFLELELNDASNREATTARKYFTELFGKDFKRREGSNALNAALNYGYSILLSAVNRKITMDGNRTYMGVHHSSKHNPFNLGSDLMEPFRPFVDYWLYDHKNIKEFTPDIKYGLVELLSLRIIYNGDRMILGNAINQYVHDCLRYLDGNLFEMDIELGVDYEVPNDAIDDNV
>NZ_CP013610.1|WP_060598264.1|760896_765159_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MAKPKDYTIGLDIGTNSVGWVVTDDQNNILRIKGKKAIGARLFTEGKVAAERRSFRTTRRRLSRRRWRIKMLEELFDEEIAKVDPSFFARLHESWISPKDKRKRYSAIVFPSPEEDKKFHESYPTIYHLRDKLMKDDQKHDIREIYIAVHQMIKARGNFLHDESVETYRSGMSSLGGRSERNILSVQTLEELNDLFAENEGTEEVELNVASAEQINDILTGGHLNADSQKEISNLLLPSSFPSFDDKAKEKQVKKLINNVATNISKAWLGYKADFSTILNLAKVDKDQKKIFAFALQGGDEEDKVQELESLLEQSQTDIVDRLIEIRHAIVLSEIVPVGMTLSEAMIDKYDQHKEDLITLKAVIRNTKDKKKAAKLQAIYDLYVKNRHADLAKAMKLTGIKKRSELLDPEELKKGISSLLDDSPEAVEIKQRLEEKTFLPLQRSNNNGVIPNQLHQVELDEIIKKQSKYYPFLAEKNPDESEEAQKKAPTKLDALLTFRVPYYVGPMITKEEQEAQNGHSFAWMVRRDPQDHEAITPWNFEKKVDKMASATQFIKRMTTKDTYLLGEDVLPASSLKYQLFTVLNELNNLRVNGKKLTSDEKEQVIEGLFKKQKTVKADKFVKYWQAKHIGADIKVKGLSDPSKFNSTMSTYIDFKKIFGDQLNDVNRQNDFEKIIEYSTIFEDRKILEDKLRVDFAWLSEEQIKQLCRLRLQGWGRLSDKLLTRLTDADGQNVLERLWNSNDNFVQIVSDPNIKAKIEQENQKLLRDSQSDNAVESILDDAYTSPQNKKAIRQVMRVVHDIVKACDGNVPAKFAIEFARSQEDDPKRTTARVNQMQKIYDQISDEVVSQGVKEQLSGMKSLKDRYYLYFMQGGRDAYTGAKLNIDRLSDYDVDHIMPQSFVKDDSLDNRVLVARAVNNQKSDKVPALLFGNKVVADLGITVREMWDKWQKLGMISKRKLSNLLTDSDALTEYRAQGFIRRQLVETSQVIKLTATILQSEFPDSKIIEVPAKYNSIVRKQFDLYKSREVNDFHHAIDAYLSTIVGNYLYQVYPNLRRMFVYGEFKKFSSNAEESAHDVARRVKSMNFLDDLLRGTHGDNIYCRSTGEIVFNRNDIISKLKQAYSFKQMLVTQEVFTKKSALFNQTVYPSPKRDGSKRSGLIPRKRGMDPEIYGGYAHNQDSYFVLAKIEKVKGYTLQIVGVPIRSLEIINKAEDFSTALLDIIKSKVMYNEKTGQPKRGIKNVEILVNKLPYRQPILEKDVSYMLGSSAYKYNIKQITLSRQSMKYILDYIDDPNFTKHEMTMIDEQNERECLLSVYDEILEKVDKYLPLFDGNKFREKLHSARKEFVSLSVDDEASAIEKILRGLHANSEMPSLENLKIKPALGFFQMKNGITLSNDAVLLYQSPTGLFERRVKVSDLLK
>NZ_CP013610.1|WP_060597959.1|759477_760737_+|HAMP-domain-containing-histidine-kinase
MIKKIRRRFIWLATLSLFLVMFFSFSSLIGISLFESSHEADQVLSIIVKNNGRLDEVQAKKRLGDQYNKEGMFKYRYFTANINTKKQTLTVIDADHIIGYSINSVSGRKKQISRRLSAGQLKGTIHSNGVRFRYLAKKISANKYYICFIDLSPLMQSALLLVRYALIFTFGGILVFVIIMTLLADKAIQPIKDAYYKQRRFITNAGHELKTPLAVISANAEMEELLGNDDEWSESTKEQVVRMTGLINQLITLTRMSEPEELVLSKVNFSEITKESADSFKSVLAKDNKKYVVSIDPDLYINAEQRSLLELVNILIDNAQKYCDPEGEVMVVLAKSRLNQNAVLTVTNSYKNGAGIDTNRFFERFYREDESHHYDQKQKNGFGIGLSMAQDLVAAFGGKINASWSDGVMNFTVTFKRVH
>NZ_CP013610.1|WP_060597958.1|758806_759475_+|response-regulator-transcription-factor
MKILLAEDEAQLNRVLTVAMQKSGYDVDSVFNGQEAVDAVKKHPYDVIIMDIMMPVKNGLDAVNEIRSTGDKTYIMMLTAKSEIDDKVTGLDVGADDYLTKPFSLKELLARLRSKERRSEDYNSTQELNYDNLKLDLNSQELSSNNSISLSKQETGLMRYFLLNPGKAISTEELFNHVWKNEDESEDVVWVYISFLRSKLASIGANVQISGEKGGEFCLERA
>NZ_CP013610.1|WP_060597957.1|758195_758810_+|GTP-pyrophosphokinase
MSIYGKYADYLPQILDSVLQQIQGIGQEYSAEHGQKLYGHLEGRVKGEESMAQKCERKGLPLTTESALIENRDAIGLRIVCNFIDDIYTCIDLLKKQDNFKIINEKDYITDAKPNGYRSYHLIMEVVTPFEDVHGNKPGTYYVEIQLRTIAMDTWASLEHEMKYKHDIKNPERISKELKRVADELASCDVSMQTIRQLIKEGEL
>NZ_CP013610.1|WP_060597956.1|757548_757995_+|FMN-binding-protein
MYKKGDYEVEAEGHHSTVKLRVSFDEEKLTKIEVLEENETQAFVDDLKDRFIPEVVANQSLNVDAISGATKLAKAVTSSVEEAITEAGGDPKTFIEAAHVAKDDQVIPGMYVVGTDYSPYYDIPGFCYGSCIGSGVIAGHGASAYAKA
>NZ_CP013610.1|WP_060597955.1|756871_757096_-|helix-turn-helix-domain-containing-protein
MNALQEYLDQNGVTRYQVAKQTGIANTTLANAVKETKPLSGQTVKVISAVAQTLGKTPGQVLDDLIELDEDNSK
>NZ_CP013610.1|WP_011543818.1|756328_756532_+|hypothetical-protein
MGESKEDKRMRAKWESLSGAEKSEFKKNYAMRRGITIDFIRRWAWNEGDLDNLEYHIAERRKKFREF
>NZ_CP013610.1|WP_060597962.1|768980_770081_+|thiolase-family-protein
MQDIYIVAAKRTPFGRYHKQLADFSAIDLGQIALRGALKEAGLDAEDLDALFMGNVLSAGLGQNMARQIALNAGMRQDSVAVSINEVCGSSLKAARLAEAQMLIGDLGLVAVGGSESMTNAPKEIMFSDGLVDSFSGKSMGITAENVAKRNHISRQDADAFSLSSHQKAVKAQAEGLFADEIIQIEDLKQDENVRPDTSLEALAGLKTSFLEDGTVTAGNASPISDGASMIILATAEKVAEYQLTPLAKLGAYAEVGYDPEFMGYGPYYAIRKLLNETGRQVADYDFFEINEAFAATTLAVARDLEIPLAKVNKQGGAIALGHPLGASGTRLLATAARQLQRGGQRAIASLCIGGGLAIAFEIEKA
>NZ_CP013610.1|WP_060597963.1|770082_771309_+|hydroxymethylglutaryl-CoA-reductase,-degradative
MKFYQLPPEERRQFLQEDGVALEDIPAADLARLDEMSENVVGEVKFPLSCLTSALVNGKNWRIPMTTEEASVVAAANHGMSVFAKAGGVKATSQRDGIYGQIVLEVTEAFSLAGFKKEFPAYIKEANKEFASLIRHGGGLKDLTARQEADLVYLLALVDPAEAMGANKTNAILEFLAQKMLAFPGVEAKLFAILSNYPSQLTTAKVAIPVSLLSKKGDLAEGRELAKKMALLAKIGSSDPYRAVTNNKGIMNGVDAVMLATGNDYRAVEAACHAYAAKSGQYRSLSSWKLEGENLLGQVTLPLALGVVGGSISSRPDIRQSYAILGKIKAAELAELTASVALANNFAALSAISTKGIQAGHMRLQSRNVVQTLPASAEEKEAVYQMMISQGKYGETAAKNFLKELRGQ
>NZ_CP013610.1|WP_003619893.1|771312_772476_+|hydroxymethylglutaryl-CoA-synthase
MDIGIDQIGFYTPNKFVDMVDLANARNQDPNKFLIGIGQDRMAVADKTQDAVSMGINATAEYLDQVDLEQLGLLIFATESGIDQSKSASLFVKEALNLPARIRTFEIKEACFALTASLQVARDYVRAHPHHSAMIIGSDIARYGLATAGEVTQGAGAISMLIKENPAIIALEDGHTSHSENINDFWRPNNLATAVVDGHYSRDVYLDFFKSTFKPFLAEKQLQVSDFAGICYHLPYTKMGYKAHKIAIEGQDDETVKRLSDNFQLSAKYSRQVGNIYTASLYMSVLSLLENGDLEAGDRIGFFSYGSGAMAEFFSGKVVAGYQKRLRPALHARMLKERIRLGVGQYEDIFTEGLEALPENVEFTSDANHGTWYLAGQEGYVRQYKQK
>NZ_CP013610.1|WP_060597964.1|772640_773999_+|threonine/serine-exporter-family-protein
MKTESTEQEYQHHLSHHHHMQVQWEEFFQSDDETKIKEATLIEKGSIISRVGMMILSCGTGAWRVRDAMDTLARTLDLTCSTDIGLISIVCTYFDVDNQSYSQSLALPTTGINMAKLNELEKFVRQFEAAGGDFEIKTVRRRLGEIEHMKGRYPLWGSSLAAALACSGFIFLLGGGLPEIICSFIGAGLGQFARGSLAKRRITVAATTAVGVAAACLSYYLAFMLGHLLFNVDMIHMRGYIGAMLFVIPGFPFITSGLDIAKLDMRSGLERMAYAILIILIATGTGWVMATALQIKPGDLPALHLSKAILTACRLLASFCGVFGFSLMFNSHRRMAAAAGLVGAIANTMRLSLVDFAHFPAPLAAFLAALLAGLLAGYVREKVGYPRIALTVPSIVIMVPGLYMYRGIFFLALTNVGAGATWMTEALMLVMSLPAGLLTARILNDKKWRRVD
>NZ_CP013610.1|WP_003619897.1|774056_774563_-|aminoacyl-tRNA-deacylase
MSKKKKNKDKLDKTLVEKILDQHKIAYEQHISEISEDHGVAQVGTGKPVLDGHPVYKTLAVNGNKTGPIVGVVPLSGHLDLKKIAKASGNKKCEMIPLKQLEKTTGYVHGANTPIGIYHSKKFPIFLDESVLKEDGIWVSSGEVGRSVMVNPLDLQKLVKATVADLQE
>NZ_CP013610.1|WP_060597965.1|774643_775588_+|50S-ribosomal-protein-L11-methyltransferase
MKLLEIKIESSYDVEDALAYFATEDLKALGTEARRRSDFEQAGWLHDSTVVDMDDIPNLPDELEFIAYFDEETDPEEMVKRFKDKLAELAGYGLKTAPGEISVDYVADQDWNTVWKKYYHVINLSRHLAIVPEWEDYQPAFKDQEIIRLDPGLAFGTGNHQTTQLAMLGIERAMVKPLTVADVGTGSGILAIAAHKLGAKSVLATDISDESMTAAEENAALNGIYDIALQKTSLLADVDGKFDLIVANILAEILLDLIPQLDSHLNEDGQVIFSGIDYLQLPKIEQALAENSFQIDLKMRAGRWIGLAISRKHD
>NZ_CP013610.1|WP_060597966.1|775728_777990_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MSKYTEMTHEQVMAACNKYMTANQLAFVESAYQFAARAHEGQTRASGQPYIVHPTQVAGILANLGLDPDTVAAGFLHDTVEDTSVTNDDIKEKFGADVAFIVDGVTKLNKYEYKSHKEFLAENHRKMLIAMAKDLRVILVKLADRLHNMHTLEHLRPDKQRRIAAETLDIYAPLADRLGIGTIKWKLEDMSFHYMNPEAYYKIVSMMDAKRSEREGYIKDAIDYLRGTLDSLGIKYDISGRPKHIYSIYKKMVNKHKNFNEIYDLLAVRVIVPTVKDCYAVLGAVHTKWKPMPGRFKDYIAMPKANGYQSLHTTIIGPGGKPLEIQIRTEEMHKVAEYGVAAHWAYKRGNFQGVDEKEGGALDIGREILELQKDSSDADEFMEAVHSDIFADKVYVFTPKGEVYELPKGSVTLDFAYAIHTQVGDHAIGAKVNDKLVPLDYKLKNGDVVDILTQSNARPSRDWAEMVKTSRAKNKIRRYFRDVDREESLARGKSELVDLLKENGLSAKDFLDKSHIDEVLDHFSFKTDEDMYAAIGFGNMSAVSIYNRLTADLRRQQEEEKQKQFEAQIMSAGQQAAASSVVKKAAPQKDDAKSKTKGKKPDSLVRVQGLEDLDMHFAKCCNPVPGDLIVGYVTKGRGVTVHRVDCRNVVSADPAAQGRMIDVEWNNIDEGKQASFNANFELFGYNRQKLLGDVINRLNALTKNITNVSASVNEENIAHFYITVEVRNAAQLNDIMAKLRDIPDVYDTKRTDN
>NZ_CP013610.1|WP_003619905.1|778018_778456_+|D-tyrosyl-tRNA(Tyr)-deacylase
MRVVIQRVNHAAVRIDGETVGQIQKGLLLLVGLAEGDGEEQVVKAADKIAKMRIFEDEAGKTNLGIKDVGGQILSVSQFTLLADTKRGNRPSFVHAMRPPKSSQLWEEFNQELVKRGLTVETGEFGADMKVELENDGPFTIVLDL
>NZ_CP013610.1|WP_003624319.1|778739_780026_+|histidine--tRNA-ligase
MRVQRPKGTVDILPETSGQWEKVEQTARDLFKRANYHEIRTPSFENYELFSRSSGETSDVVEKEMYDFEDKGGRHIALRPEGTAGVVRAYVENKIYGPDYVKPFNVYYIAAMYRYERPQAGRQREFHQIGVESFGSNGYLADVETILLGHDLLAELGVKNYELHINTLGDSEVRQAYHDALVDYFTPVKDQLSEDSQRRLGKNPLRILDSKAEEDQQFLSEAPKIRDYLDEESKENFNKILASLDKLGVKYVIDDDLVRGLDYYTGVIFEFMVDDPTLWASPSTVLGGGRYNHLVEEFSGPETPAVGFGIGEERLMLVLSKQNPEMFEDQGIDFFITNIGEGTDIKAVEVARQLRSLGFSAQYDVDQKKLKAQFRKADRVGARYVVTLGAKELAEGKLTVKRLSDGQQFSLEFTDLEDKTNLLSKIEK
>NZ_CP013610.1|WP_060597967.1|780041_781886_+|aspartate--tRNA-ligase
MMQMEKRTDYCGNITSQYLDQDVLLYGWVQRVRNLGQLIFIDLRDREGIVQVVVNHDSGQELMDVASSLGQEYVVEVKGHVNERSSKNPDMKTGDVEVIASEITVLNKAKTPPFEIKDDLVASEQTRLKYRYLDLRRPTLQNALIMRAQIMTATNAYLSGVGFINIETPDLGKSTPEGARDYLVPSRVYPGSFYALPQSPQIFKQLLMGAGFDKYYQIARCFRDEDLRGDRQPEFTQIDLETSFMDEEGVQEVTEGLLAKVMKDVKGIDLQLPLPRITWQESMDKYGCDKPDTRYEMLIHDLGNVFAKSGFKVFASALENGGFVRGIAVKGGAKFYSRKKIEAMQDYIKRYHAKGLAWVKYEDGDFSGPVSRFLSEEEKAGLVQEFSLEGGELLLFIADQWKVCCDSLDYLRRQTAKETGIIPKDTYKYLWVVDWPLFEYDEGDERWIAAHHPFTMPDDKGIELLETDPHKAHARSYDIVLNGYELGGGSIRIHKRDIQEKMFKALGFTKERAYEQFGFLMDALDMGFPPHAGLAIGLDRFAMLLAGKDNIRDVIAFPKNASASEPMMHAPAPVADQQLTDLGIEVAEAAKEGVEKYEASLEAEAAEDVKSHEE

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Crispr_ID: NZ_CP013610_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013610_3

1796223-1796325

Orphan

Consensus_repeat	Method
GTTGGCGTAGGGGAGTGAGAACGATGAAGATCGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013610_3

>merge|NZ_CP013610|3|1796223-1796325|CRISPRCasFinder
GTTGGCGTAGGGGAGTGAGAACGATGAAGATCGATGTTATTCGATACCTCGACGACAGTGGTATAATAGTTGGCGTAGGGAAGTGAGAACGATGAAGATCGAT

>NZ_CP013610|3|3|1796223-1796325|CRISPRCasFinder
GTTGGCGTAGGGGAGTGAGAACGATGAAGATCGAT	GTTATTCGATACCTCGACGACAGTGGTATAATA
GTTGGCGTAGGGAAGTGAGAACGATGAAGATCGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013610.1\|WP_003616492.1\|1800875_1801073_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP013610.1\|WP_003624630.1\|1796673_1798764_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NZ_CP013610.1\|WP_003620346.1\|1803427_1804177_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|224982
NZ_CP013610.1\|WP_003624033.1\|1802362_1803274_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP013610.1\|WP_003620448.1\|1786322_1787237_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013610.1\|WP_080582668.1\|1799597_1799861_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP013610.1\|WP_060598222.1\|1783477_1784881_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NZ_CP013610.1\|WP_060598226.1\|1805052_1805931_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|283645
NZ_CP013610.1\|WP_155589469.1\|1798982_1799156_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013610.1\|WP_014565400.1\|1789024_1790605_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP013610.1\|WP_014565408.1\|1801510_1801813_+\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_CP013610.1\|WP_003624638.1\|1793111_1793870_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NZ_CP013610.1\|WP_011544317.1\|1785326_1785566_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|236766
NZ_CP013610.1\|WP_060598224.1\|1788130_1788913_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NZ_CP013610.1\|WP_081044860.1\|1799785_1800448_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|283235
NZ_CP013610.1\|WP_003620345.1\|1804181_1804988_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319818
NZ_CP013610.1\|WP_003620452.1\|1787630_1788131_-\|O-acetyl-ADP-ribose-deacetylase	unknown	unknown	gnl\|CDD\|394878
NZ_CP013610.1\|WP_003624639.1\|1790591_1792787_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|223589
NZ_CP013610.1\|WP_060598223.1\|1787295_1787535_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013610.1\|WP_003620465.1\|1795450_1796119_+\|cobyric-acid-synthase	unknown	unknown	gnl\|CDD\|225974

Protein	Function_ID	Function_description	E-value
NZ_CP013610.1\|WP_003616492.1\|1800875_1801073_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	8.85016e-33
NZ_CP013610.1\|WP_003624630.1\|1796673_1798764_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP013610.1\|WP_003620346.1\|1803427_1804177_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl\|CDD\|224982	COG2071, COG2071, Predicted glutamine amidotransferases [General function prediction only].	6.08738e-85
NZ_CP013610.1\|WP_003624033.1\|1802362_1803274_-\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	8.49631e-22
NZ_CP013610.1\|WP_081044860.1\|1799785_1800448_-\|hypothetical-protein	gnl\|CDD\|283235	pfam05525, Branch_AA_trans, Branched-chain amino acid transport protein. This family consists of several bacterial branched-chain amino acid transport proteins which are responsible for the transport of leucine, isoleucine and valine via proton motive force.	2.74036e-43
NZ_CP013610.1\|WP_080582668.1\|1799597_1799861_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.3701e-06
NZ_CP013610.1\|WP_060598222.1\|1783477_1784881_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NZ_CP013610.1\|WP_060598226.1\|1805052_1805931_-\|alpha/beta-hydrolase	gnl\|CDD\|283645	pfam06028, DUF915, Alpha/beta hydrolase of unknown function (DUF915). This family consists of several bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.	1.90863e-57
NZ_CP013610.1\|WP_014565400.1\|1789024_1790605_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.26845e-65
NZ_CP013610.1\|WP_014565408.1\|1801510_1801813_+\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	1.97915e-35
NZ_CP013610.1\|WP_003624638.1\|1793111_1793870_-\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	4.24726e-64
NZ_CP013610.1\|WP_011544317.1\|1785326_1785566_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|236766	PRK10811, rne, ribonuclease E; Reviewed.	0.00182211
NZ_CP013610.1\|WP_060598224.1\|1788130_1788913_-\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	7.66079e-73
NZ_CP013610.1\|WP_003620345.1\|1804181_1804988_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.06283e-71
NZ_CP013610.1\|WP_003620452.1\|1787630_1788131_-\|O-acetyl-ADP-ribose-deacetylase	gnl\|CDD\|394878	cd02908, Macro_OAADPr_deacetylase, macrodomain, O-acetyl-ADP-ribose (OAADPr) family. Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. This family includes eukaryotic macrodomain proteins such as human MacroD1 and MacroD2, and bacterial proteins such as Escherichia coli YmdB; these have been shown to be O-acetyl-ADP-ribose (OAADPr) deacetylases that efficiently catalyze the hydrolysis of OAADPr to produce ADP-ribose and free acetate. OAADPr is a sirtuin reaction product generated from the NAD+-dependent protein deacetylation reactions and has been implicated as a signaling molecule. By acting on mono-ADP-ribosylated substrates, OAADPr deacteylases may reverse cellular ADP-ribosylation.	3.16627e-94
NZ_CP013610.1\|WP_003624639.1\|1790591_1792787_-\|serine/threonine-protein-kinase	gnl\|CDD\|223589	COG0515, SPS1, Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair].	1.05424e-08
NZ_CP013610.1\|WP_003620465.1\|1795450_1796119_+\|cobyric-acid-synthase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	1.65312e-72

>NZ_CP013610.1|WP_003620465.1|1795450_1796119_+|cobyric-acid-synthase
MDDNLIRIAYLYEDLMNTYGDSGDVKILRYFLQKKGWQTQIDNISLGSQFNAADYDFVFFGGGQDYEQSIVAKDLQRFKETLNDYIQAGNPMLAICGGYELMGTHYNTISGTKIKGLGILPLHTEFDPEKRMIGDTKYETEWGPTIGFENHSGQTFLDDRKMLKPFAKVVEGYGNNHEEKEDGVRYKNFIGSWSHGPMLKNENVANALVDMILKRHAARVAQ
>NZ_CP013610.1|WP_003624638.1|1793111_1793870_-|tyrosine-protein-phosphatase
MPKRIVKLEAGYNCRDLGGYVSQDGRTVKWGRLYRSGSLSHLTKADQSELVRRKIVVDCDLRSRHEQDNFPDKLWPGAKLVDAHFYSESGDEEEEAEAAWEKYSGKLPKLSYLAMVYQQNLVAPRTGLVMRKIFKEMLALEDDEALIYHCSMGKDRTGMVSVIVLMALGLEDREILRDYLLSREYSWDWDEADENDRLGQQIAKMNQTQVSQTAFYGITETIRQTWGGFDRYFASLGFGQGDLDRLRDKFLE
>NZ_CP013610.1|WP_003624639.1|1790591_1792787_-|serine/threonine-protein-kinase
MKYKLINGDFCVRQYNHVDVVPTNFLGLSREIISRDPHHVFLQINKSAASLPRQGFKIHVSATLQNYQVILDKVYDLSCENNFTFKYISNYSLLEQYLGGTGPLWMTGKYITIYPETESRFEKLIRTIYDLVGKEDGIPIFTDQAFRDSKNVYYRYGIINSDDDFIRDERNNKLYRDHELRTYQLPSFVKEPFESKNEHKLETIGKKYLLKGIISRKSSGGVYRAQDIYGRDVVIKRAKYRFKDSEETEIQKLQNERKNLINWEKYDFIPKVLDSFYEQKDFFLVESYIKGVLIDDLRAEFIGDKRNSFYFAKIRHIVLNYLRCLQRLHNDSFFLGDISASNIIVDFESEKVFLVDVSQSALLTNMDESFYYRTKGFYDRRVDNLSPELQDVHQSGYLVMSVFSRANDFLKIDQSGKQSWNFFIKQAAQEKIPAVFIKVMKVLINATAGSLDRAIEILQKDDMNVLSQITTTQQLPLKSLLQGLQRPVAIEQIEENSLDEKNSEDEVVKALLSVELGNNNCPVPAFEQSQLKIFEELSRTRPSMEKILRQLFLIVEYLRERVPTASVKFDNFDITIKKIESMFWVENNDFCGYRLFAKSKYISPYLKNGMAGMLIVLMNAKVIYQTKAYDRRIKQLANELSKMAYAKNGTFIEGLSGITWILIKYVEQSHDRDYMPLIERQLSFYQYFCVDCHGLMYLIDSRSEALDTSLFYGNRGMAFVLKEWEKLNENR
>NZ_CP013610.1|WP_014565400.1|1789024_1790605_-|ABC-transporter-ATP-binding-protein
MKIGELVKQNRLRFTCAVALEVLGQLCVAVGNYIIGFILDLLVKRETSRFYLVLAVFFVLYIGGYVLISFAEYLYIVQVQEYVHQLRRKTVDYYYQNHETVAEMQSHLTNDFQMLFDNFTQPLFVFFDSALAVVFSAYALVTMHWILLVTTVLLSVMFLYLPSIFSKKYQERTLIFSNMNTAYLTSIKNWLGGLAEIQRYDARHKLVEVLEKRSKKLEGSLVTRQVSAIEINFINGFMSIFCQVVLDVVTGTLILAGTISIGKLVAVGQFSSTIFNSLVMLSNYLEQIKSTKPLNEKVAAALADPPKDVCTDEELTSFDHLQTTGLSFSYDHGETINYPDLKIKVGEKILLTGDSGTGKSTLLKVLAGELKATTGNIAFYDHDDRKIDISLKAMHYVPQDPVLFPVSIAENITMFKPKLDDKVGEYLQKVDLAKDIAKFPKGQDTVIDVEELNVSGGQRQKIVLARAELNQSDFILIDEATAAVDQDSTKRILKNLLKTNATIIFIGHNFTNEMVDMFDRQIVLSK
>NZ_CP013610.1|WP_060598224.1|1788130_1788913_-|tyrosine-protein-phosphatase
MEMQRVIELDMPVNFRDLGGYQGLDGRQVKWRKIYRSAALNEMSARDRVKLANLRITVDCDLRSSREQRSYPDLLWPGVRFVNIGLYAEGDRFNQAHPFLRLFHHLPEFDDYLPKIYQQVLLNEHSEEGIKRVFEELLKLPEDQALVYHCAAGKDRTGIISILILMALGVDDKTIAEDYLLTDELYDFSIEKQHPTNEKLSLVIAKMNVTRGEGTAVKGITETIRQGWGSFDKFFTRKLGFKQADLEKFREMYLEEEEED
>NZ_CP013610.1|WP_003620452.1|1787630_1788131_-|O-acetyl-ADP-ribose-deacetylase
MNLEIWQGDITTLKVDAIVNAANRELRGGGGVDGAIHRAAGPKLNEACRALGSCETGEAKITPGFNLPAKYIIHTVGPVYSGSHSDPLLLAACYRNSLRVAKENGLHSVAFSAISTGVYGYPLDAASKVAFGEVRKWLREHKDYEMRVIMVAYDARTYALYQKLLG
>NZ_CP013610.1|WP_060598223.1|1787295_1787535_-|hypothetical-protein
MLRKYYVTIVFTLLALLNLLSSWGTLQYRLVMLAFNLVCGFSMEYLVNKKAPAEKYNLWKGCTAAVLLAVNLLWIFLTK
>NZ_CP013610.1|WP_003620448.1|1786322_1787237_+|hypothetical-protein
MARMSRRQYQERQEQTAQKQTRQTNPNSVPRLDTDGASRSEQKVRLNFWQIFADRPYVTVIMISLALFCILAKWWIGLAIIIILTIAGIFVIGRSHHPNRVLSLEFKLKASRKLSMIKALQLLGSTIMFLAAYMRQIVSVDFSSAGATDSLTVIQNMLSNQGTFGQQGSYFLSLFNQLTGGSLWGTYRYATNSSQMMNSTAGTMIILWIFLLMIAPAFCVLSQFFREPYSRHVMTVASLISTISFTLTPTLMNRWVISYAVQNQMSQAAAENAVQVGGMVYPAIISAVFVFILAIYREIKKDEF
>NZ_CP013610.1|WP_011544317.1|1785326_1785566_-|LPXTG-cell-wall-anchor-domain-containing-protein
MTVVNTDEEPATKSAAKTPTLVTKLANTAPVAKAPAATAAQLPQTGEKDAKPGILAGILSLLAGVSLFGFSFEKRKQEK
>NZ_CP013610.1|WP_060598222.1|1783477_1784881_-|class-II-fumarate-hydratase
MAEQEYRIESDTIGEVKIPKEALWGPQTERSRNNFPSGELMPLAIIRAFLHLKKAAAESNVEVGDEPAEKGQAIEEAIDQLLALSDEDLRKNFPLHVLQTGSGTQTNMNVNEVVANLANKLHPGLNILPNDDVNRGQSSNDTYPTAMNIVAVEAVDKLEPAIEHLIDELKVKQDKYWKTVKVGRTHLQDATPLTFGQEVSGYISALKHDLAYIQELKPSLYELAIGGTAVGTGLNAAPGMTEAIAGKLSEVYGHEFRVDTNKFWGLAHHSALSVMHGAFKTLANDMFKIAQDIRFLASGPRAGYGELNIPANEPGSSIMPGKVNPTQAEAVTMAVARVLGNDVTINFAASQGNFEMNVFKTVMIAAFLESADILAGTITGFADKMIHGLTVNEQRMDDLLENSLMTVTALSPKIGYHEAAVIAQTAQREGTTLKEAALKSGKVTEEQYDEWMDYMAMTNIDRTKPEE
>NZ_CP013610.1|WP_003624630.1|1796673_1798764_+|ATP-dependent-Clp-protease-ATP-binding-subunit
MDYNNFNDMDDLFRELMNGLGGFNSENRRYLINGRQVTPEEFAEYQKTGQLPGQGQAKNFQGKQKKANGILEKLGRNLTAEAREGKLDPVIGRNKEIQETAEILSRRIKNNPVLVGDAGVGKTAVVEGLAQAIVHGDVPEAIKNKEIISIDISSLEAGTQYRGSFEQNIQDLVKEVKDRGNVILFFDEIHQILGAGGMGDGNGSKGMSDILKPALSRGEITVIGATTQDEYRNTIMKDAALARRFNEVTVNAPSQADTFKILMGIRSLYEKHHNVELPDDVLKAAIDYSVQYIPQRSLPDKAIDLLDMTAAHLAAQHPVTDAKTIEKQIKEEKQAQKKAAENEDYQAALDHKTKAEKLEKQLSENHEERKTVATPADVAAAVERLTGIPVSKMGASDIERLKGLSSRLKGKIIGQDEAVEAVAKAIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDMFGSKDAIIRLDMSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTEKVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNTIIIATSNAGFGNEQLMGDAKKDEKLMDRLAPYFRPEFLNRFNAVIEFSHLTKEDLKEIVNLMLADVNKTLAKKGISLTVSESAKDYLIEQGYDEAMGARPLRRVIEQEIRDKVTDYYLDHLDVKKLKADMVDGALVISEDK
>NZ_CP013610.1|WP_155589469.1|1798982_1799156_-|hypothetical-protein
MDVEADHFWQSQAVVVQKVLVSPQEVPLSVLPEDAQLDLVGDGIPEVFRLDLPATWY
>NZ_CP013610.1|WP_080582668.1|1799597_1799861_+|diguanylate-cyclase
MVLRDFTDTDTVAEKDRQFRKELEHARVLDLYMNITVSAGYAYGIANNSDEIKSMIRLADHNLYQVKKNGRKDICGSPFQPNFFEYE
>NZ_CP013610.1|WP_081044860.1|1799785_1800448_-|hypothetical-protein
MGFAGIAIIYLILVALGAGSLHYFKLSENGGIAFAQIAHHYLDTFGEALLATLATITCMFTAIGLVVAFAQDFHKRFPKISYRTFLTFNCLFSFAIANFGLTTIIAWSTPVLMFLYPLAIALIFCGLTSKFFNNDPAVYKFAVYFTIIPAIFDGLNAAPSIISNTAFAKAALAFAGRYLPQKIQRESKLSFHAVSFYSYSKKFGWKGLPQMSLRPFFLTW
>NZ_CP013610.1|WP_003616492.1|1800875_1801073_+|cold-shock-protein
MQNGTVKWFNADKGFGFITGSDGDVFVHFSSIKTNGFKSLEEGQKVSYDVEQGNRGPQATNVVPQ
>NZ_CP013610.1|WP_014565408.1|1801510_1801813_+|recombinase-family-protein
MAKIGYARVSSKEQHLDRQLAALKDVDKLFTDKLSGANTNRPELQKMLAYIREGDIVMVTELDRLGRNNQDLTNSLANKYSIKLLVMALMPPACTSGGGK
>NZ_CP013610.1|WP_003624033.1|1802362_1803274_-|EamA-family-transporter
MKDKHLGILLAITGAALWGTSGTAAEMLYQSPNINTFWLVDVRSWLAGASLLLISLVHKGKGTFAIFKNPRDLLYAALFSMLGITGAQFTYFYTVAASNAPTATVLVFLAPVLIICFMAAKTRQMPRRIDLIAVLLAVVGTVVLVTNGNFSHLAVTPKTLVWGFFSALTQALAIAMPAKLFKKYGTITILAWGMLLGGIILSPALAVMPATGVTVKEWSLVIYIVIAGTVFAYSLYLSSVMYISAGLVSMLEAFEPLVATILSVTLLGSDFGIMKMAGGVLIILATCLQVVPSPRRGKLQRKL
>NZ_CP013610.1|WP_003620346.1|1803427_1804177_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MVKAVIGISASEVTIQSGPFMGEPRTYVNAAYVDSVLKNGGIPLVIPFTAGGEEMAFKQLDLVDGLILSGGHDLNPHLYGEEIDQKSGETWPDRDAFDMALLKRAEETGKPVLGICRGAQIINVAHGGSMWQDLSLRPGNTLKHMQAIRPDVGTHVVKIKSGTTLKKIMGESSLMTNSFHHQLIKEVAPDLTESASASDGVTEALESTDGKVIAVQWHPEEMHANPAPEAAIMNRLFKYLIDKAEEEKQ
>NZ_CP013610.1|WP_003620345.1|1804181_1804988_-|Cof-type-HAD-IIB-family-hydrolase
MKIKLIAVDLDGTLLTSRKKVSPKTLATLKKAREKGILVVPLSGRPLPGVLKVFEPFKLDPADNFAICYNGGLVQRMDGEVLSASPLTDENVEHMLALKQTGIFGPYFMDTKDFYVAPKGSSFGVGFLAKARNMGVKRMVPGQHYEFIKGEFVSLPSKIKKFRAGFSPATEQEFEISASGGQCLEFNTPGTSKGQALTTLLDLLNIQPEEAMVFGDNNNDLSDFQLPGVFKVAMGNAIDEIKAAADYVTASNNQDGIALAVEKFVDMG
>NZ_CP013610.1|WP_060598226.1|1805052_1805931_-|alpha/beta-hydrolase
MFKSRNWKLIVVALTIIILLAVPGYSWMKKTNKEHAERQRSQLSPLIMVPGSSATVNRFNELVDLLNENTPYKHSLLKVEISEDGTLTYSGSMKKEDNEPFIVIGFQNNHDGYSNIKKQAGWLDDAFYEIAKTYMFNNFKAFGHSNGGLIWTYWLEHYYSNNYSDEITIKSLMTLGSPYNFSEKSIKYKTQMMTDFIKYRKRLPKNMIVYSLSGGENYESDGIVPESSVEAGKYIFQNQVKSYTTMTVTGAEAQHSSLPQNKQVVKIIQEYLLKQQVKPGPNNSQNSKHKEN

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP013610_2	2.6\|767635\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767635-767664	30	NC_004937	Lactobacillus delbrueckii subsp. lactis plasmid pLL1212, complete plasmid sequence	4410-4439	3	0.9
NZ_CP013610_2	2.6\|767635\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767635-767664	30	NC_004849	Lactobacillus delbrueckii subsp. lactis plasmid pJBL2	7039-7068	3	0.9
NZ_CP013610_2	2.6\|767635\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767635-767664	30	NC_002191	Lactobacillus delbrueckii subsp. bulgaricus plasmid pLBB1, complete plasmid sequence	4703-4732	3	0.9
NZ_CP013610_2	2.6\|767635\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767635-767664	30	NC_010909	Lactobacillus delbrueckii subsp. bulgaricus plasmid pDOJ1, complete sequence	4799-4828	4	0.867
NZ_CP013610_2	2.6\|767635\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767635-767664	30	NC_014728	Lactobacillus delbrueckii subsp. bulgaricus ND02 plasmid unnamed, complete sequence	4799-4828	4	0.867
NZ_CP013610_2	2.6\|767635\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767635-767664	30	NZ_MF191707	Lactobacillus delbrueckii strain BioLb89 plasmid p89, complete sequence	4632-4661	5	0.833
NZ_CP013610_2	2.6\|767635\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767635-767664	30	CP029251	Lactobacillus delbrueckii subsp. lactis isolate NWC_1_2 plasmid p1, complete sequence	2584-2613	5	0.833
NZ_CP013610_2	2.6\|767635\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767635-767664	30	CP031024	Lactobacillus delbrueckii subsp. lactis isolate NWC_2_2 plasmid pNWC_2_2, complete sequence	3807-3836	5	0.833
NZ_CP013610_2	2.6\|767635\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767635-767664	30	NC_004850	Lactobacillus delbrueckii subsp. lactis plasmid pN42	6726-6755	5	0.833
NZ_CP013610_2	2.9\|767833\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767833-767862	30	NZ_LR594664	Variovorax sp. RA8 plasmid 3	181983-182012	6	0.8
NZ_CP013610_2	2.14\|768163\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	768163-768192	30	NZ_CP033894	Serratia liquefaciens strain FG3 plasmid p1-159, complete sequence	137628-137657	6	0.8
NZ_CP013610_2	2.6\|767635\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767635-767664	30	NC_019777	Cyanobacterium aponinum PCC 10605 plasmid pCYAN10605.01, complete sequence	12288-12317	7	0.767
NZ_CP013610_2	2.7\|767701\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767701-767730	30	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	771705-771734	7	0.767
NZ_CP013610_2	2.7\|767701\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767701-767730	30	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	2137343-2137372	7	0.767
NZ_CP013610_2	2.20\|768560\|30\|NZ_CP013610\|CRISPRCasFinder,CRT	768560-768589	30	NZ_CP019037	Massilia putida strain 6NM-7 plasmid unnamed2, complete sequence	25171-25200	7	0.767
NZ_CP013610_2	2.20\|768560\|30\|NZ_CP013610\|CRISPRCasFinder,CRT	768560-768589	30	AP013753	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C63A-MedDCM-OCT-S44-C48, * SEQUENCING IN PROGRESS *	9981-10010	7	0.767
NZ_CP013610_2	2.20\|768560\|30\|NZ_CP013610\|CRISPRCasFinder,CRT	768560-768589	30	AP013471	Uncultured Mediterranean phage uvMED DNA, complete genome, group G18, isolate: uvMED-CGR-C63A-MedDCM-OCT-S41-C57	15908-15937	7	0.767
NZ_CP013610_2	2.20\|768560\|30\|NZ_CP013610\|CRISPRCasFinder,CRT	768560-768589	30	AP013752	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C63A-MedDCM-OCT-S30-C46, * SEQUENCING IN PROGRESS *	6201-6230	7	0.767
NZ_CP013610_2	2.4\|767503\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767503-767532	30	NC_029071	Salmonella phage 36, complete genome	34053-34082	8	0.733
NZ_CP013610_2	2.14\|768163\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	768163-768192	30	NZ_LR699116	Aquicella lusitana strain SGT-39 plasmid 3	74914-74943	8	0.733
NZ_CP013610_2	2.15\|768229\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	768229-768258	30	LR606149	Rhizobium sp. Q54 genome assembly, plasmid: 6	134529-134558	8	0.733
NZ_CP013610_2	2.15\|768229\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	768229-768258	30	NC_048733	Microbacterium phage Burro, complete genome	24231-24260	8	0.733
NZ_CP013610_2	2.16\|768295\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	768295-768324	30	MG557979	Lactobacillus phage Lpa804, complete genome	11269-11298	8	0.733
NZ_CP013610_2	2.19\|768493\|31\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	768493-768523	31	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	2527534-2527564	8	0.742
NZ_CP013610_2	2.20\|768560\|30\|NZ_CP013610\|CRISPRCasFinder,CRT	768560-768589	30	NC_009928	Acaryochloris marina MBIC11017 plasmid pREB3, complete sequence	65263-65292	8	0.733
NZ_CP013610_2	2.20\|768560\|30\|NZ_CP013610\|CRISPRCasFinder,CRT	768560-768589	30	NC_009926	Acaryochloris marina MBIC11017 plasmid pREB1, complete sequence	59718-59747	8	0.733
NZ_CP013610_2	2.4\|767503\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767503-767532	30	AY308796	Bacteriophage TLS, complete genome	38481-38510	9	0.7
NZ_CP013610_2	2.4\|767503\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767503-767532	30	NC_009540	Enterobacteria phage TLS, complete genome	38481-38510	9	0.7
NZ_CP013610_2	2.4\|767503\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767503-767532	30	NC_047823	Citrobacter phage CF1 DK-2017, complete genome	20132-20161	9	0.7
NZ_CP013610_2	2.4\|767503\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767503-767532	30	LR597656	Escherichia phage Stevie_ev116 genome assembly, chromosome: 1	29660-29689	9	0.7
NZ_CP013610_2	2.4\|767503\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767503-767532	30	NC_042066	Salmonella phage FSL SP-126, partial genome	45399-45428	9	0.7
NZ_CP013610_2	2.4\|767503\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	767503-767532	30	MH102284	Salmonella phage vB_SenS_PHB07, complete genome	8320-8349	9	0.7
NZ_CP013610_2	2.15\|768229\|30\|NZ_CP013610\|PILER-CR,CRISPRCasFinder,CRT	768229-768258	30	NC_013855	Azospirillum sp. B510 plasmid pAB510a, complete sequence	1160570-1160599	9	0.7

1. spacer 2.6|767635|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_004937 (Lactobacillus delbrueckii subsp. lactis plasmid pLL1212, complete plasmid sequence) position: , mismatch: 3, identity: 0.9

cagactcattgtcaagaccttacagaagtt	CRISPR spacer
ccaactcattgtcaaaaccttacagaagtt	Protospacer
* .************.**************

2. spacer 2.6|767635|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_004849 (Lactobacillus delbrueckii subsp. lactis plasmid pJBL2) position: , mismatch: 3, identity: 0.9

cagactcattgtcaagaccttacagaagtt	CRISPR spacer
ccaactcattgtcaaaaccttacagaagtt	Protospacer
* .************.**************

3. spacer 2.6|767635|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_002191 (Lactobacillus delbrueckii subsp. bulgaricus plasmid pLBB1, complete plasmid sequence) position: , mismatch: 3, identity: 0.9

cagactcattgtcaagaccttacagaagtt	CRISPR spacer
ccggcttattgtcaagaccttacagaagtt	Protospacer
* *.**.***********************

4. spacer 2.6|767635|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_010909 (Lactobacillus delbrueckii subsp. bulgaricus plasmid pDOJ1, complete sequence) position: , mismatch: 4, identity: 0.867

cagactcattgtcaagaccttacagaagtt	CRISPR spacer
ccggcttattgtcaagaccttacaaaagtt	Protospacer
* *.**.*****************.*****

5. spacer 2.6|767635|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_014728 (Lactobacillus delbrueckii subsp. bulgaricus ND02 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.867

cagactcattgtcaagaccttacagaagtt	CRISPR spacer
ccggcttattgtcaagaccttacaaaagtt	Protospacer
* *.**.*****************.*****

6. spacer 2.6|767635|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NZ_MF191707 (Lactobacillus delbrueckii strain BioLb89 plasmid p89, complete sequence) position: , mismatch: 5, identity: 0.833

cagactcattgtcaagaccttacagaagtt	CRISPR spacer
tcggcttattgtcaagaccttacaaaagtt	Protospacer
. *.**.*****************.*****

7. spacer 2.6|767635|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to CP029251 (Lactobacillus delbrueckii subsp. lactis isolate NWC_1_2 plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.833

cagactcattgtcaagaccttacagaagtt	CRISPR spacer
tcggcttattgtcaaggccttacagaagtt	Protospacer
. *.**.*********.*************

8. spacer 2.6|767635|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to CP031024 (Lactobacillus delbrueckii subsp. lactis isolate NWC_2_2 plasmid pNWC_2_2, complete sequence) position: , mismatch: 5, identity: 0.833

cagactcattgtcaagaccttacagaagtt	CRISPR spacer
tcggcttattgtcaaggccttacagaagtt	Protospacer
. *.**.*********.*************

9. spacer 2.6|767635|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_004850 (Lactobacillus delbrueckii subsp. lactis plasmid pN42) position: , mismatch: 5, identity: 0.833

cagactcattgtcaagaccttacagaagtt	CRISPR spacer
tcggcttattgtcaaggccttacagaagtt	Protospacer
. *.**.*********.*************

10. spacer 2.9|767833|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR594664 (Variovorax sp. RA8 plasmid 3) position: , mismatch: 6, identity: 0.8

gctgccatggcgtcaatcggccgggtgtta	CRISPR spacer
cctgccatggcttcaatcggccgaaagttg	Protospacer
 ********** ***********.. ***.

11. spacer 2.14|768163|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033894 (Serratia liquefaciens strain FG3 plasmid p1-159, complete sequence) position: , mismatch: 6, identity: 0.8

aataactgtgtgattttaatcggaagactg	CRISPR spacer
aataactatgtgattctaatcggagatccg	Protospacer
*******.*******.********.. *.*

12. spacer 2.6|767635|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_019777 (Cyanobacterium aponinum PCC 10605 plasmid pCYAN10605.01, complete sequence) position: , mismatch: 7, identity: 0.767

cagactcattgtcaagaccttacagaagtt	CRISPR spacer
ccaaaacattatcaagaccatacagaagta	Protospacer
* .*  ****.******** *********

13. spacer 2.7|767701|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 7, identity: 0.767

atttgtcaaggagtacggctggcggattga	CRISPR spacer
agcggtcaaggagtacagccggcggattag	Protospacer
* . ************.**.********..

14. spacer 2.7|767701|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 7, identity: 0.767

atttgtcaaggagtacggctggcggattga	CRISPR spacer
agcggtcaaggagtacagccggcggattag	Protospacer
* . ************.**.********..

15. spacer 2.20|768560|30|NZ_CP013610|CRISPRCasFinder,CRT matches to NZ_CP019037 (Massilia putida strain 6NM-7 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.767

caaccgacatcactgttgctcaaggcgcag	CRISPR spacer
gccgtgacatcgctgttgcacaaggcgcag	Protospacer
    .******.******* **********

16. spacer 2.20|768560|30|NZ_CP013610|CRISPRCasFinder,CRT matches to AP013753 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C63A-MedDCM-OCT-S44-C48, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.767

caaccgacatcactgttgctcaaggcgcag	CRISPR spacer
taaccgacatgactgttgatcaagcactag	Protospacer
.********* ******* *****   .**

17. spacer 2.20|768560|30|NZ_CP013610|CRISPRCasFinder,CRT matches to AP013471 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G18, isolate: uvMED-CGR-C63A-MedDCM-OCT-S41-C57) position: , mismatch: 7, identity: 0.767

caaccgacatcactgttgctcaaggcgcag	CRISPR spacer
taaccgacatgactgttgatcaagcactag	Protospacer
.********* ******* *****   .**

18. spacer 2.20|768560|30|NZ_CP013610|CRISPRCasFinder,CRT matches to AP013752 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C63A-MedDCM-OCT-S30-C46, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.767

caaccgacatcactgttgctcaaggcgcag	CRISPR spacer
taaccgacatgactgttgatcaagcactag	Protospacer
.********* ******* *****   .**

19. spacer 2.4|767503|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_029071 (Salmonella phage 36, complete genome) position: , mismatch: 8, identity: 0.733

ggcttttgccttgcacgacttttgcctgca	CRISPR spacer
tgcttttgccttgcacaactttcatatggt	Protospacer
 ***************.*****... **

20. spacer 2.14|768163|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR699116 (Aquicella lusitana strain SGT-39 plasmid 3) position: , mismatch: 8, identity: 0.733

aataactgtgtgattttaatcggaagactg	CRISPR spacer
tgtttaggtgcgattttaatcggacgactg	Protospacer
 .*    ***.************* *****

21. spacer 2.15|768229|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to LR606149 (Rhizobium sp. Q54 genome assembly, plasmid: 6) position: , mismatch: 8, identity: 0.733

catatccgtgcgctcagcctcatggacagc	CRISPR spacer
ggcaagcgttcgctcagcctcattgacagg	Protospacer
 ..*  *** ************* *****

22. spacer 2.15|768229|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_048733 (Microbacterium phage Burro, complete genome) position: , mismatch: 8, identity: 0.733

catatccgtgcgctcagcctcatggacagc	CRISPR spacer
gcccgcggtgagctcagcgtcatggacagc	Protospacer
  .  * *** ******* ***********

23. spacer 2.16|768295|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to MG557979 (Lactobacillus phage Lpa804, complete genome) position: , mismatch: 8, identity: 0.733

caaatttaagccaaatgctgataccagcac	CRISPR spacer
caactttaagccatatgctgataatctaag	Protospacer
*** ********* ********* .   *

24. spacer 2.19|768493|31|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 8, identity: 0.742

acaaatatcgcggttttgatcggtcgtccga	CRISPR spacer
caatatatcgcgctgttgatcggtcgtgccg	Protospacer
  * ******** * ************ * .

25. spacer 2.20|768560|30|NZ_CP013610|CRISPRCasFinder,CRT matches to NC_009928 (Acaryochloris marina MBIC11017 plasmid pREB3, complete sequence) position: , mismatch: 8, identity: 0.733

caaccgacatcactgttgctcaaggcgcag	CRISPR spacer
ataccgacctcactgttgttcaaggatgac	Protospacer
  ****** *********.******   *

26. spacer 2.20|768560|30|NZ_CP013610|CRISPRCasFinder,CRT matches to NC_009926 (Acaryochloris marina MBIC11017 plasmid pREB1, complete sequence) position: , mismatch: 8, identity: 0.733

caaccgacatcactgttgctcaaggcgcag	CRISPR spacer
ataccgacctcactgttgttcaaggatgac	Protospacer
  ****** *********.******   *

27. spacer 2.4|767503|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to AY308796 (Bacteriophage TLS, complete genome) position: , mismatch: 9, identity: 0.7

ggcttttgccttgcacgacttttgcctgca	CRISPR spacer
tgcttttgccttgcacaactttcatatagt	Protospacer
 ***************.*****... *.

28. spacer 2.4|767503|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_009540 (Enterobacteria phage TLS, complete genome) position: , mismatch: 9, identity: 0.7

ggcttttgccttgcacgacttttgcctgca	CRISPR spacer
tgcttttgccttgcacaactttcatatagt	Protospacer
 ***************.*****... *.

29. spacer 2.4|767503|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_047823 (Citrobacter phage CF1 DK-2017, complete genome) position: , mismatch: 9, identity: 0.7

ggcttttgccttgcacgacttttgcctgca	CRISPR spacer
tgcttttgccttgcacaactttcatatatt	Protospacer
 ***************.*****... *..

30. spacer 2.4|767503|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to LR597656 (Escherichia phage Stevie_ev116 genome assembly, chromosome: 1) position: , mismatch: 9, identity: 0.7

ggcttttgccttgcacgacttttgcctgca	CRISPR spacer
tgcttttgccttgcacaactttcatatatt	Protospacer
 ***************.*****... *..

31. spacer 2.4|767503|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_042066 (Salmonella phage FSL SP-126, partial genome) position: , mismatch: 9, identity: 0.7

ggcttttgccttgcacgacttttgcctgca	CRISPR spacer
tgcttttgccttgcacaactttcatatagt	Protospacer
 ***************.*****... *.

32. spacer 2.4|767503|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to MH102284 (Salmonella phage vB_SenS_PHB07, complete genome) position: , mismatch: 9, identity: 0.7

ggcttttgccttgcacgacttttgcctgca	CRISPR spacer
tgcttttgccttgcacaactttcatatagt	Protospacer
 ***************.*****... *.

33. spacer 2.15|768229|30|NZ_CP013610|PILER-CR,CRISPRCasFinder,CRT matches to NC_013855 (Azospirillum sp. B510 plasmid pAB510a, complete sequence) position: , mismatch: 9, identity: 0.7

catatccgtgcgctcagcctcatggacagc	CRISPR spacer
gtccgccgtgcgcccatcctcatggacatg	Protospacer
  .  ********.** ***********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

228806 : 245358

Planktothrix_phage(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003619471.1\|228806_229850_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.7e-19	32.2
WP_003619469.1\|229864_230818_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.6e-21	33.3
WP_081044819.1\|230899_231037_+	DUF975 family protein	NA	NA	NA	NA
WP_060597824.1\|231171_232485_-	aminopeptidase	R4TV59	Phaeocystis_globosa_virus	1.3e-61	32.5
WP_060597825.1\|232536_233850_-	aminopeptidase	R4TV59	Phaeocystis_globosa_virus	8.8e-63	33.5
WP_003619462.1\|233946_234372_-	Hsp20/alpha crystallin family protein	NA	NA	NA	NA
WP_011677979.1\|234600_235062_+	transcription elongation factor GreA	NA	NA	NA	NA
WP_003622306.1\|235145_236435_-	adenylosuccinate synthase	L7Y4J5	Megavirus	1.6e-72	38.2
WP_003622309.1\|236620_237613_+	GMP reductase	Q4ZCY7	Staphylococcus_virus	1.8e-132	68.4
WP_060597826.1\|237741_239049_+	Y-family DNA polymerase	M1Q231	Streptococcus_phage	1.0e-87	40.8
WP_003619451.1\|239041_239401_+	hypothetical protein	E3W8I0	Leuconostoc_phage	7.8e-06	34.8
WP_060597827.1\|239470_240763_-	purine permease	Q9KX94	Enterobacteria_phage	6.3e-29	31.1
WP_003619447.1\|240792_241362_-	xanthine phosphoribosyltransferase	NA	NA	NA	NA
WP_003619444.1\|241716_242874_+	guanosine monophosphate reductase	A0A1V0SHK8	Klosneuvirus	4.1e-56	31.3
WP_003619442.1\|242873_244427_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	3.5e-18	30.2
WP_003616790.1\|244748_245000_+	type II toxin-antitoxin system HicA family toxin	NA	NA	NA	NA
WP_003616793.1\|244986_245358_+	toxin-antitoxin system HicB family antitoxin	A0A0K2CZV4	Paenibacillus_phage	8.9e-21	45.6

DBSCAN-SWA_2

960470 : 1053347

Streptococcus_phage(27.78%)

protease,transposase,tRNA,integrase

attL 956480:956498|attR 1053803:1053821

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
956480:956498	attL	NA	NA	NA	NA
WP_003621053.1\|960470_961112_-\|integrase	tyrosine-type recombinase/integrase	A3F636	Streptococcus_phage	2.3e-24	34.9
WP_060597994.1\|963220_964507_+	MATE family efflux transporter	NA	NA	NA	NA
WP_060597993.1\|964713_964938_-	diguanylate cyclase	NA	NA	NA	NA
WP_011543913.1\|976937_977888_-	2-hydroxyacid dehydrogenase	A0A1J0F959	Only_Syngen_Nebraska_virus	7.6e-32	34.2
WP_060598004.1\|978074_978536_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_011678292.1\|978535_980263_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.6e-32	27.2
WP_060598005.1\|980262_982020_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.3e-41	24.5
WP_060598006.1\|982102_982411_-	rhodanese-like domain-containing protein	NA	NA	NA	NA
WP_081044835.1\|982455_982854_-	ribonuclease HI	M4QMN0	Micromonas_pusilla_virus	2.4e-08	34.7
WP_011543917.1\|984721_985204_-	hypothetical protein	NA	NA	NA	NA
WP_060598007.1\|985410_985677_-	N-acetyltransferase	NA	NA	NA	NA
WP_011678298.1\|985678_986398_-	HAD family hydrolase	M1H9H9	Acanthocystis_turfacea_Chlorella_virus	1.9e-06	24.6
WP_060598008.1\|986737_986935_-	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_081044836.1\|987196_987937_-	FAD-binding protein	NA	NA	NA	NA
WP_060598009.1\|988142_989366_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	6.6e-97	48.2
WP_060598010.1\|989623_990409_-	DNA polymerase III subunit epsilon	A0A1X9I5C8	Streptococcus_phage	1.1e-17	31.3
WP_060598011.1\|991020_991794_-	DUF218 domain-containing protein	NA	NA	NA	NA
WP_060598012.1\|991786_992086_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_060598013.1\|994564_995008_-	hypothetical protein	NA	NA	NA	NA
WP_060598015.1\|995323_997357_-	DUF87 domain-containing protein	NA	NA	NA	NA
WP_060598016.1\|997349_998645_-	SIR2 family protein	NA	NA	NA	NA
WP_060598019.1\|999310_999769_-	hypothetical protein	NA	NA	NA	NA
WP_081044837.1\|1000023_1000953_-	restriction endonuclease	NA	NA	NA	NA
WP_060598021.1\|1001737_1004920_-	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	1.4e-18	22.4
WP_138464002.1\|1005032_1005281_-	hypothetical protein	NA	NA	NA	NA
WP_060598023.1\|1005604_1006795_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	2.6e-05	23.5
WP_060598269.1\|1006787_1009379_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	1.7e-97	42.4
WP_060598024.1\|1009773_1009983_-	type II toxin-antitoxin system RelB/DinJ family antitoxin	NA	NA	NA	NA
WP_013439619.1\|1012113_1012305_-	hypothetical protein	NA	NA	NA	NA
WP_041806519.1\|1012354_1013203_-	LD-carboxypeptidase	NA	NA	NA	NA
WP_060598025.1\|1013247_1014672_-	NOL1/NOP2/sun family putative RNA methylase	NA	NA	NA	NA
WP_003623050.1\|1014664_1015639_-	hypothetical protein	NA	NA	NA	NA
WP_003623049.1\|1015638_1016379_-	hypothetical protein	NA	NA	NA	NA
WP_002880372.1\|1016489_1016687_-	hypothetical protein	NA	NA	NA	NA
WP_035175777.1\|1016832_1017444_-	pyroglutamyl-peptidase I	NA	NA	NA	NA
WP_011543931.1\|1017522_1018275_+\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_060598026.1\|1019425_1020856_-	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_003620545.1\|1020956_1022477_-	ABC transporter permease/substrate-binding protein	NA	NA	NA	NA
WP_060598027.1\|1022480_1023404_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.1e-26	38.7
WP_003623037.1\|1023737_1024199_+	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_041806782.1\|1024645_1025065_+	3-beta hydroxysteroid dehydrogenase	NA	NA	NA	NA
WP_003620537.1\|1025126_1026038_-	M48 family metallopeptidase	NA	NA	NA	NA
WP_060598028.1\|1026757_1027930_-	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_011543937.1\|1027947_1028109_-	hypothetical protein	NA	NA	NA	NA
WP_060598029.1\|1028199_1034076_-	S8 family serine peptidase	A0A1B0T6A2	Bacillus_phage	7.8e-10	30.3
WP_060598030.1\|1034865_1035336_-	hypothetical protein	NA	NA	NA	NA
WP_060598031.1\|1035456_1036071_+	DedA family protein	NA	NA	NA	NA
WP_060598032.1\|1036421_1037438_+	aspartate--ammonia ligase	A0A1C9C5F0	Heterosigma_akashiwo_virus	4.1e-60	39.1
WP_011543871.1\|1037513_1038812_+\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	8.2e-53	28.4
WP_060598033.1\|1038864_1040169_-\|transposase	ISL3-like element ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	1.4e-57	33.0
WP_060598034.1\|1040425_1041649_-\|transposase	IS110-like element ISL4 family transposase	A0A1X9I619	Streptococcus_phage	1.3e-95	48.2
WP_003619632.1\|1043098_1046125_-	DUF4981 domain-containing protein	L0N6M2	Herpes_simplex_virus	1.3e-141	32.9
WP_060598035.1\|1046128_1048012_-	PTS sugar transporter subunit IIA	NA	NA	NA	NA
WP_003618241.1\|1052019_1052331_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_011678333.1\|1052510_1053347_+\|integrase	site-specific integrase	NA	NA	NA	NA
1053803:1053821	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1103077 : 1116468

Erwinia_phage(12.5%)

protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003623888.1\|1103077_1104472_-\|protease	ATP-dependent protease ATPase subunit HslU	A0A1B2IB03	Erwinia_phage	8.5e-32	26.2
WP_003618695.1\|1104474_1105008_-\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_003618694.1\|1105117_1106005_-	tyrosine recombinase XerC	S5W9T9	Leptospira_phage	1.4e-24	30.2
WP_003618693.1\|1106004_1107324_-\|tRNA	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	NA	NA	NA	NA
WP_060598057.1\|1107455_1109639_-	type I DNA topoisomerase	A0A1V0SCS0	Indivirus	4.7e-93	34.8
WP_003618691.1\|1109765_1110605_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	1.4e-29	37.4
WP_014565035.1\|1110703_1111474_-	ribonuclease HII	G9E3X7	Emiliania_huxleyi_virus	9.5e-25	37.2
WP_003623895.1\|1111463_1112321_-	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_002880201.1\|1112395_1112626_-	YozE family protein	NA	NA	NA	NA
WP_011543974.1\|1112629_1113475_-	DegV family protein	A0A0N9SI50	Staphylococcus_phage	1.0e-19	45.0
WP_003623898.1\|1113609_1114272_+	hemolysin III family protein	NA	NA	NA	NA
WP_003618685.1\|1114297_1115488_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	2.4e-43	47.8
WP_003618684.1\|1115568_1116468_+	YitT family protein	M1Q1P6	Streptococcus_phage	1.8e-51	39.8

DBSCAN-SWA_4

1269484 : 1278056

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004560838.1\|1269484_1270066_-	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	1.9e-25	35.4
WP_035169900.1\|1270065_1271109_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	8.3e-64	41.3
WP_004560839.1\|1271111_1272590_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.9e-51	33.2
WP_004560840.1\|1272565_1274788_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.1e-142	40.1
WP_003618413.1\|1274787_1275462_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_003615547.1\|1275461_1275710_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_003615550.1\|1275714_1276437_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	1.3e-36	36.8
WP_011544054.1\|1276760_1278056_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.4e-20	32.6

DBSCAN-SWA_5

1713233 : 1719011

Streptomyces_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060598203.1\|1713233_1714013_-	hydrolase	A0A1V0DZX6	Clostridioides_phage	1.1e-07	36.9
WP_014565354.1\|1714914_1715697_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	4.5e-14	42.7
WP_011544282.1\|1715884_1716358_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	1.9e-15	41.9
WP_060598204.1\|1716528_1717575_-	lactate dehydrogenase	M1H502	Paramecium_bursaria_Chlorella_virus	1.2e-27	29.7
WP_003621166.1\|1717858_1718344_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	2.3e-16	41.1
WP_059217012.1\|1718468_1719011_-	AAA family ATPase	U5J9X2	Bacillus_phage	1.7e-12	35.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP013610

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection