CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP013743	Streptomyces sp. CdTB01 chromosome, complete genome	13 crisprs	DEDDh,Cas14u_CAS-V,csa3,WYL,DinG,cas3,cas4,Cas9_archaeal	0	5	0	0
NZ_CP013744	Streptomyces sp. CdTB01 plasmid unnamed, complete sequence	1 crisprs	cas2,csa3,DEDDh	0	4	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP013743_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_1

251866-251959

Orphan

Consensus_repeat	Method
CGTGCGCGGCGATCACGGTCGGGCCGCGGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013743_1

>merge|NZ_CP013743|1|251866-251959|CRISPRCasFinder
CGTGCGCGGCGATCACGGTCGGGCCGCGGTCATCGGCCGGCGTGGCAGCGGAGGCGAAGGAAGCGTGCGCGGCGATCACGGTGGGGCCGCGGTC

>NZ_CP013743|1|1|251866-251959|CRISPRCasFinder
CGTGCGCGGCGATCACGGTCGGGCCGCGGTC	ATCGGCCGGCGTGGCAGCGGAGGCGAAGGAAG
CGTGCGCGGCGATCACGGTGGGGCCGCGGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_058920500.1\|223005_232545_-\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
NZ_CP013743.1\|WP_107416234.1\|260247_261789_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP013743.1\|WP_058920513.1\|254413_254713_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378956
NZ_CP013743.1\|WP_058920507.1\|246012_246939_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234835
NZ_CP013743.1\|WP_079078342.1\|261881_263453_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|312032
NZ_CP013743.1\|WP_058927851.1\|254922_255345_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP013743.1\|WP_058920515.1\|257689_257929_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058920512.1\|253464_254271_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|377092
NZ_CP013743.1\|WP_058920516.1\|257925_259080_+\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP013743.1\|WP_058927850.1\|245702_245915_+\|MbtH-family-protein	unknown	unknown	gnl\|CDD\|377081
NZ_CP013743.1\|WP_058920501.1\|232541_240701_-\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
NZ_CP013743.1\|WP_058920508.1\|247107_248478_-\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379262
NZ_CP013743.1\|WP_058920511.1\|252524_252959_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058920504.1\|243122_244439_-\|methylaspartate-mutase	unknown	unknown	gnl\|CDD\|238149
NZ_CP013743.1\|WP_058920509.1\|248653_251704_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276938
NZ_CP013743.1\|WP_058920502.1\|240828_242106_-\|glutamate-synthase	unknown	unknown	gnl\|CDD\|239202
NZ_CP013743.1\|WP_058920505.1\|244435_244933_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179400
NZ_CP013743.1\|WP_058927852.1\|259456_260134_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|378924
NZ_CP013743.1\|WP_058920506.1\|245271_245553_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180839
NZ_CP013743.1\|WP_058920514.1\|255606_257376_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367570

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_058920500.1\|223005_232545_-\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NZ_CP013743.1\|WP_058920513.1\|254413_254713_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|378956	pfam12802, MarR_2, MarR family. The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	3.41001e-05
NZ_CP013743.1\|WP_058920507.1\|246012_246939_-\|hypothetical-protein	gnl\|CDD\|234835	PRK00779, PRK00779, ornithine carbamoyltransferase; Provisional.	3.95538e-88
NZ_CP013743.1\|WP_079078342.1\|261881_263453_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	2.44486e-09
NZ_CP013743.1\|WP_058927851.1\|254922_255345_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.74571e-15
NZ_CP013743.1\|WP_107416234.1\|260247_261789_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.72049e-66
NZ_CP013743.1\|WP_058920512.1\|253464_254271_-\|ABC-transporter-permease	gnl\|CDD\|377092	pfam03649, UPF0014, Uncharacterized protein family (UPF0014).	4.08508e-42
NZ_CP013743.1\|WP_058920516.1\|257925_259080_+\|serine/threonine-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	9.06932e-39
NZ_CP013743.1\|WP_058927850.1\|245702_245915_+\|MbtH-family-protein	gnl\|CDD\|377081	pfam03621, MbtH, MbtH-like protein. This domain is found in the MbtH protein as well as at the N-terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.	3.97015e-24
NZ_CP013743.1\|WP_058920501.1\|232541_240701_-\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NZ_CP013743.1\|WP_058920508.1\|247107_248478_-\|XRE-family-transcriptional-regulator	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	3.18426e-07
NZ_CP013743.1\|WP_058920504.1\|243122_244439_-\|methylaspartate-mutase	gnl\|CDD\|238149	cd00245, Glm_e, Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate. The first step in the catalysis is a homolytic cleavage of the Co-C bond of the coenzyme B12 cofactor to generate a 5'-deoxyadenosyl radical. This radical then initiates the rearrangement reaction. C. cochlearium Glm is a sigma2epsilon2 heterotetramer. Glm plays a role in glutamate fermentation in Clostridium sp. and in members of the family Enterobacteriaceae, and in the synthesis of the lipopeptide antibiotic friulimicin in Actinoplanes friuliensis. S. tendae Tu901 glutamate mutase-like proteins NikU and NIkV participate in the synthesis of the peptidyl nucleoside antibiotic nikkomycin. NikU and NikV proteins have sequence similarity to Clostridium Glm sigma and epsilon components respectively, and may catalyze the rearrangement of 2-oxoglutaric acid to 2-keto-3-methylsuccinic acid during nikkomycin synthesis.	3.21061e-147
NZ_CP013743.1\|WP_058920509.1\|248653_251704_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	1.84976e-38
NZ_CP013743.1\|WP_058920502.1\|240828_242106_-\|glutamate-synthase	gnl\|CDD\|239202	cd02808, GltS_FMN, Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.	3.92437e-28
NZ_CP013743.1\|WP_058920505.1\|244435_244933_-\|hypothetical-protein	gnl\|CDD\|179400	PRK02261, PRK02261, methylaspartate mutase subunit S; Provisional.	2.43644e-10
NZ_CP013743.1\|WP_058927852.1\|259456_260134_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|378924	pfam12697, Abhydrolase_6, Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.	2.00658e-09
NZ_CP013743.1\|WP_058920506.1\|245271_245553_+\|hypothetical-protein	gnl\|CDD\|180839	PRK07103, PRK07103, polyketide beta-ketoacyl:acyl carrier protein synthase; Validated.	0.00985435
NZ_CP013743.1\|WP_058920514.1\|255606_257376_-\|hypothetical-protein	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	1.50349e-20

>NZ_CP013743.1|WP_058920509.1|248653_251704_+|tetratricopeptide-repeat-protein
MSDAEAGSLRFNVLGPLEGWADGSRLRLGGLIQERVLGTLLLEPGRVLPISRLVESAWAENPPATASHQVRKAIAYLRRRIPDGGEVIVTDGPGYRAVLTPEQLDLTEFALLVKTARNAMGEGRPGEAAEALRRALGLWRGPILSGAGGPVIEAAATAFEERRLAAAEYLFELRLGFGESSELVVDLRDFVRSHPLRETLRAQLMLALYRAGRQAEALEEYGRVRELLVEELGVDPGPGLTRVYEGILREDPKLAAPPPSPPAPVPAPAPASPPAAVPAAPADALCTLPYDLADFTGRERELTELLDCAGRDYARHSRIVALDGMGGSGKTSLAVHAAHQLADAFPDGQLYIDLRGYTPGEEPVTAGGALDSLLRALGIPGERIPEDLAGRTALWRATITGRRLLLLLDNAADADGVRPLMPTGPGCLVLVTSRARLVDLDSAHWISVDVMSPQECAKLVAETLGEQRYAAEPEAAAELARLCGHLPLALRIATARLRNRPRWTLRYLADRLRDEARRLDELSSGQRSVAATLRLSYQALDQECRTAFRILALHPRGDIDVHAAAALLGTDPRDAEDILELLLDVHLMQQPEIGLYTFHDLVRSFAHSLRSEATEGDDDASVHRLLDYYLTAAESACQVMFPGRRQIPTGREETGVPVPRFAGRGQAEQWFAREQGALLGMVGVARRLGCDRHTVLLTRNLAFQLSARGQLEEFRTMGLEAVSAARRLGELPLLGVSLSNLGVACWKLGRFTEAVEIATEGRDVAEQLGDLQTMAHSESTLGQLNSLLGHFPQALSHLEKSIAYERRLGASRAEAESLTLLSTLYEQWGRHEEAAAAARRAITLCDELGRHENKLVALTDLAFAQACLGDDEAAEVSLKQARALCEDNRDPGQVALTSALSAEVCHRLGRTERAAEFGEHALNTVSSNVSPLRRAKVENTVGRYLLRRGDAAPALSLHERAYELAGSLDFRIEMAYAHSGIARAQTALGRSEEADRHERSAEELFTAMGVPAGRRR
>NZ_CP013743.1|WP_058920508.1|247107_248478_-|XRE-family-transcriptional-regulator
MTEQAATDGLARQLIAARRWAGITQEQLAGLSTVSVRAIRDLEQGRVRHPRRETLRLLADAMRLGDVRRAALELAVEGAPADSVMRDAFGAELAPPPEPLRRLVGRGEELRALTGLLATEHERLLTVVGIAGVGKTRLAQEAALLMHTRDRMPVLWVDMETAVPQPVSATVRSPRAALTGWARSLAVGGPGLDELASVVGDRAALMVLDGHDAVPRLAPQLLELLHGCERLKVLITAREPHRTPGNRLLPLAPLPLPAPQPSADAASPLPGQSLTAGEPAVELMLSYVGHMRPDLLPTDSVVRTVAQVCHALDAVPRAMESAASWLLLHSLEELLAIARTSPLDLVDDAALSDVNEEGLGALLAAAVDRLDDTQATLLGDLGALADGWTAEQASAVLAVPAATVAREVHALMLRGLVRRLPATGEGASRFGVLNLVRGLAADRAETAARQSVALVH
>NZ_CP013743.1|WP_058920507.1|246012_246939_-|hypothetical-protein
MRNLISLADLRPEQLARIVARAVEFGRGDVTDRPLAGRQVGIYFRKSSTRTRTSFWSGATRLGADVITFGPDELQLSTGETVEDTSRVLGQYLDALVVRTNGDVEEMRRLGTSPHLAVVNALSLDEHPTQAVADLTTLTEHFGSLAGRHLLVVGEGNSSGAALALAGALVPELRVTLLCPAGYEVPKNTLDLVDELSGGRHQVVQITDPDAVQGPVDAIYTSRWQTMGVPKADPDWLASFEGFRIDRDFFDRYSGPDTVFLHDLPAVRGQEVTDEILDGERSLAWRQAYHKMTAAMAVLEWCVVGPRD
>NZ_CP013743.1|WP_058927850.1|245702_245915_+|MbtH-family-protein
MATNPFDDADGRFVVLVNDEGQHSLWPARVRRPDGWQQVREEGSKQECTEYVEANWTDLRPRSVVAAMGG
>NZ_CP013743.1|WP_058920506.1|245271_245553_+|hypothetical-protein
MSQLVPVAAPDASLTAALRAAMSRTDRHEPVGEAKFAVLEAALQLLDADRPELADQPQLRTELLREALGSVRAAAVAAGVAVTRARQVTGAPV
>NZ_CP013743.1|WP_058920505.1|244435_244933_-|hypothetical-protein
MTQPAQSAPRDPSGPLDVVVTGLPSDAHTWNLVFMQLLLEDLGHHVVNLGPCIAQDEIVESCCKYQPDLLVVSSVNGHGFHDAEQLARALRARWELAGLPAVVGGKLGVHGAEGQAGHHRLLLSAGFDAVFHDEEGLAPFTAFVTALAADRTPPVPAGTRQGATR
>NZ_CP013743.1|WP_058920504.1|243122_244439_-|methylaspartate-mutase
MTSFGRFVAAARARGALVVQPRMGFSDPARMRAGLLATKGAADAVAGTLTIDSYTRVGDEPAAVRALNADVPLNGYPITSYSPLTSHWVLDGIPGPDFPVQVRHGSASPQRIVSALARLGLTATEGGPISYCLPYGRTPLVDSVRNWQQACEELAALRDEGAEPHLESFGGCMLGQLCPPGLLVAISALEGLFFHRAGLRSISLSYTQQTNPAQDRQAVRALRRLAAELLPDTDWHVVLYTYMGVYPRTPHGARALLERSAELAVRAGADRLIVKTAAEAHRIPTVAENTHALRIAARTAARTTKEAGAESHESADNPVYAEARALVDAVLDLDTDLGKALLAAFEHGYLDVPFCLHPDNAGRTRSHIDAAGRLTWSDIGALPIGRVTAPRGAQLTADGLYDALTYVQRRYDDAPAPRSAPGPQHPADEEHAHDLLEV
>NZ_CP013743.1|WP_058920502.1|240828_242106_-|glutamate-synthase
MNTALVAHGFPEEQVRARARHGAAAVFPAQSGYGSGLLGAGPHTPDADDELERIRIVPPVFMPERLKKLIDLGREPLYSDVDLETVIGGFTSRMPLYVSAFGSTQVASHDLGEAAGRQAAQLGIPLVIGENVVPVNGYRSADDAGVSPLLGRIAAYAEAAGEEYGGVAVQQSTEDADAEVWNLIYSDPVSEPLLATGRLAFELKVGQGAKPGLGGLTVLDRDTAGRVAEQYATDEVFGADSDRVLRVSSPGTFTEEILRQQVRLMRNNFPRVKVWVKLHPGRDVAEAAATAWAAGADAVTVDGAEGGTAWAPTGFLSHVGLPLADCLRRVGRKDSCLLASGRMWEGTRAVKALALGARAVGLGRAALLAVDEDREAGLRRLAEAFALEVRMLTSAVGKYHVNALDPQDLLFPAAWRMPSAAPGAA
>NZ_CP013743.1|WP_058920501.1|232541_240701_-|non-ribosomal-peptide-synthetase
MSHPHPAQAVTPVDLTAYNDTAATLPEGALHELFAAQAARTPDAPALVCEGRELTYRALDRAADALAHRLRSHGVRPGDAVALLQDRSLDYVVAVLAVLKSGGCYVPLDPRQPEQRRAFILDDTGAVLLLTDRDDQHATAFAGSVPVLRLTDDVTEPAAAPTEPLNTPVHPDQLAYVMYTSGSSGTPKGVANTHRNVVELALDPWWGAGRRHRRVLAYSPLAFDSSTYELWVPLLSGGTAIVLPAPKLDIAELAKALTEHHATAVYFTTALFDAMASEAVGALAGLEEIWTGGDVLSAPALQRVLEECPATTVVHAYGPTESTVFCSYQVFGPGERTVERLHLGVPMANTRMYVLDEGLRPVVPGVVGELYVAGSHLAWGYVGRAALSSERFVADPFGPAGERMYRTGDLARWNEHGEIVFEGRADQQVKLRGFRIELGEIESVLVAHEAVSQAAVIVREDRPGDKRLVAYVVAEADTDTLHTHCAERLAEYLVPSAFVVLPALPLTANGKLDRRALPAPQAGGATGRAPRTPAEEVLCGLFADILNMPAVGIDDDFFRLGGHSLLATRLVGRIRSALATELSLRDFFQYPTVARLAEHLTDGAGTAAARPQLTVAPRSDEDLPLSAAQRRLWFLDQMEGPSATYNIPLTLTLTGTVEPELLRAALGDVLARHEVLRTSYPEHDGEPRQHIAGPDEVSVALSVADVTEDELPGRIAKEAAHLFDLATDLPLHAALLRLTPARSVLVLVVHHIASDGWSTTPLMRDLGTAFTARAEGTAPTWEPLPVQYADYALWQRDLLAEHEEAQLEHWRTALAALPAESTLPPDRPRPAVASYRGSTHTVHCPAETHQALTALARESGATFFMVVQAATIALLSRSGAGTDIPVGSLVAGRTDEALEDLVGFFVNTLVLRTDTGGDPTFRELLDRVRETDLAAWAHQDLPFDRLVEALNPERSAARHPLFQVMLTLAEAADPAPALPGVRAETGRPGMGTAKFDLTVNFHEHRDRAGRPSGLDIVLEYATDLYDPATIETAADRLTRVLDAVITDPDVPVADIELLTDDQRRTLLTAYNDTAAALPEGTLHELFAAQAARTPHAPALVCGEHELSYRALDHASDAFARRLAGHGVVPGTAVGLFLDRSPEYVVAVLGVLKAGGTYVPLDARQPAERLAFILADTGATLVVTDRGAPAEGLTTLPPPDVPALLAEAGTEPFHAPVHADQLAYVMYTSGSSGTPKGVANTHRNVVELALDPWWGAGGRHRRVLAYSPLAFDSSTYELWVPLLSGGTAVILPVAKVDVAELGDALVRHDITAVYFTTALFDAMASEAVGALAGLEEIWTGGDVLSAPALQRVLEECPTTTVVHAYGPTESTVFCSYQVFGPGERTAERLHLGVPMANTRMYVLDEGLRPVVPGVVGELYVAGSHLAWGYVGRPGLSSERFVADPFGPAGERMYRTGDLARWNEHGEIVFEGRADQQVKLRGFRIELGEIESVLVAHEAVSQAAVIVREDRPGDKRLVAYVVAAGDGRVDTDALRRHTLAALPEYMVPAAFVELDLLPLTANGKLDRRALPEPRLGTGPGGRQGRTPVEEVLCGLFADALGLPAVGIDDDFFRLGGHSLLATRLVSRIRRTLGARLSVRDLFRQPTVARLADFLADATDTDRRPPLTAGERPQRVPLSAAQRRLWFLDQMEGPSATYNIPLAVRLTGALDADALHLALGDVVTRHEALRTVFPAEQGTPYQHILPAEQGRPALALIPVTPQALPAVLRDLSATTFDLARELPLRADLLQLQDDEHVLLLVTHHIASDGWSTTPLMRDLAAAYTARTEGAAPVWEPLPVQYADYALWQQALLAADEERQLEHWRRALQGLPEEVTLPTDRARPATSSYRGASLTVRCPAGLHASLTRLARESGTTLFMVAQAATAALLARSGAGPDIPLGSPVAGRGEEALEDLVGFFVNTLVLRTDVSGDPTFRELLDRVRTTDLAAWAHQDVPFDRLVEALNPERSAARHPLFQVMLSVTDAADPVPRLPGLHGASEFTTLDIAKFDLTFTFHEHRAPDGGPAGLGITVEYATDLYDPATVSAVTARLVRLLQAAADTPDTRIGALDVLADDERARLLDTWHGARRVRPAAALPELFAAQAARTPDAVALTHGTQRLTYAELDRRANRLAHRLIAEGVRPGSRVALFQERSVEAVVAILAVVKAGAVYVPLDTRYPKDRVDLIVRMAGAQVFLTDRDASGLQLPQGARVLAVAEAGGSFPDTAPEVGVHPDQLAYVMFTSGSTGVPKGVAVTHRNVTELAADGRFTGGAHRRILLHSPLAFDATTYELWVPLLSGGTLVVAPPGLLDTAALARILTEESITGLWLTAGLFRLVAEEDPAAFAGLGEVWTGGDVVPPEAVRRVMDACPNLQVVNGYGPTETTTFATSHFLHRPFDYAGALPIGRPLDNTRLYVLDEHLGLVAPGVPGELYIAGTGLAQGYLDRPGLTAERFVADLYGPAGSRMYRTGDLVRWSRDGEIEYLGRADQQVKLRGFRIEPGEIESALVAHPSVSQAAVIVREDRPGDKRLVAYVVGDGVDLDALRSHAHEALPDYMVPAAFMTLNALPLTANGKLDKRALPQPPVTAGSGGRAPRNPREEVLCGLFAEVLGLPSVTVDDDFFRLGGHSLLATRLVSRIRTVLGAELPVPALFENPNVARLAERLEGAENARPKLRPMRRMGASQ
>NZ_CP013743.1|WP_058920500.1|223005_232545_-|non-ribosomal-peptide-synthetase
MIPLSYAQQRLWFLAQLEGPSATYNIPLALRLSGDLDTEALTWALADVVARHESLRTLYPEREGTPYQHILPAEDARPALPVLTAGEDTLADVLAAESAHVFDLAADLPVHARLIRLGDREHVLLVVMHHIASDGWSIAPLLRDLAHAYAARRDGHAPEQQPLEIQYADFTLWQQEVLGEPDAEDSLMNRQLAYWKKQLADLPEEVTLPADRPRPAVASYRGDTVTVHCPAGTHAALADLARESGATLFMAAQAALATVLAAGGAGPDIPLGSPVAGRTEEALNDLVGFFVNTLVLRTDVTGDPTFRELLNRVRSTDLAAWAHQDVPFDRLVEILNPERSGARHPLFQVMLTLVQAGSTDPGADFRGLRARAEYSATRTAKFDLTVGFDEHLTPDGRPAGLDITAEYATDLYDRDTIEALLARLLRLLGEASARPDTPLSGLDLLDAAERTLLLDTWTGRATPVPEASLAALFAEQAARTPDAVALTHAGRSWTYAEADAVSSRFAHRLTALGVGPESVVAVLMERSADLVLALLAIVKAGGVYAPLNAVDPVSRLTRILADTAAPLLLTDPHLADHEIVAEAGTTGTRILRVDDLTADPENAPYPASAPKVATHPDQWLYVMFTSGSTGVPKGVAITHRNVAELALDHRWDRPAHRRVLFHSPHTFDASTFELWVPWLTGGTVAVAPAGVLDTAALAAVLAEESITGLWLTAGLFRLVAEEDPAAFAGLGEVWTGGDVVPPEAVRRVMDACPDLQVVNGYGPTETTTFATSHFLHRPFDYAGALPIGRPLDNTRLYVLDEHLGLVAPGVPGELYIAGAGLARGYLRRPAQSAERFVADPHGPAGARMYRTGDLVRWSRDGEIEYLGRADQQVKLRGFRIEPGEIESALVAHASVSQAAVVVREDRPGDKRLVAYVVGDGVDLDALRSHASQVLPDYMVPAAFMTLNALPLTGNGKLDRRALPAPDLSADSTGRAPRNPAEEVLCGLFADVLGRPSVTIDDHFLRLGGHSLLATRLVSRIRTAFGVRITVRDMFQHPTVAQLAELIRTSNGDQPRPALTAAERPARLPLSSAQQRLWFLDQLEGPSATYNIPLALRLTGPLDTDALRLALTDVVGRHEALRTVFRTADGEAYQLVLPADGITVPLPVTPADEDSLPALLAEESARTFDLAAALPLRASLLRLTDEDHVLVVVTHHIASDGWSNAPFFTDLHHAYAARTEGAAPEWAPLPVQYADYTLWQHQLLANEQSPQLAFWRAALADLPEEATLPTDRPRPAVASYQGATLTVSCPAATHAALTGLARESGTTLFMVAQAAVATVLSRCGGGVDVPIGSPVAGRTDEALDDLVGFFVNTLVLRTDVGGDPTFRELLARVRETDLAAWAHQDLPFDRLVEVLNPERSASRHPLFQVMLTVGDTTVSEPELGSLTARFITPETRVAKFDLTFAFGERRAADGSPDGLDITVEYATDLYDTTTAASIAGRLARLLDAAVSTPDQPVSTLPLLTDDDHSRLTHWSGPLTRAPQLGLDGLFSGQAARSPEAVALVFEDQQVTYGELEVWSNRLARYLSGKGVRPGDLVGVHVERSPHMVAAILAVLKTGAGYTMLDPQFPQERLNGVLEQVRPSALVTQSHLPPLRTDAVRIDLTGEVADISATSGAAVETGGCPESVACVMFTSGSTGVPKGVAASHRALAATFVGPDYLAFGPQQTFLQCSPVSWDAFALEVFGPLLHGGVCVLQPGQHTDPHQIVELVERHQVTTLQMSASLFNHMLDEHPAVFGQLREAMTAGEAASPAHVARALEAHPHLRLLNGYGPAESMGFTTTYTIEPGTAEGVASIPVGGPLAGKHTYVLDANLELVAPGVPGELYVAGHGLAHGYIGQPGLSADRFVANPHGPAGSRMYRTGDLARWNEQGALEYLGRGDQQIKLRGFRIEPGEVEAALTSHPLVQQAACVVREDRPGDKRLVAYVVGDTADSAALLRHTAARLPEYMVPAAVVVLDELPRTVNGKLDRRALPAPDLSAASEGRAPRNPAEEILCGLFADTLGLASVTIDDHFFHRGGHSLLATRLTSKIRQAFGVRLGVREIFQYPTAGRLAELIAAGTGADERPALLAGERPARPPLSSAQQRLWFLDQLEGPSPTYNIPLTVRLTGTLDAEALRRALLDVVGRHEALRTTFPSENGTPHQAVRSLAETDLALPVTPVTEESLHQTLARLAGVTFDLAADLPIRADLLALSPEEHVLLVVMHHIASDGWSNGPLLRDLATAYTARSQGVAPEWVPLPVQYADYSLWQRRLLTTEEERQLAFWQAELAELPQEATLPADRPRPAVASYRGATHKVTAPAATHAALTGLARESGTTLFMVAQAAVATVLSRCGGGVDVPIGSPVAGRTDEALDDLVGFFVNTLVLRTDVGGDPTFRELLARVRETDLAAWAHQDLPFDRLVEVLNPERSASRHPLFQVMLTVGDTTAGTPDLAGLETAFLDPELNIAKFDLTFAFGERRAADGSPDGLDITVEYATDLYEPRTVGLLLERTLLLLESAAAAPDTPVGSLPLLTPEEQTLLDTWSGPATAAPRLGLDGLFSAQAARSPEAVALVFEDQQVTYGELEVWSNRLARYLSGKGVRPGDLVGVHVERSPHMVAAILAVLKTGAGYTMLDPQFPQERLNGVLEQVHPAALVTQSHLPPLRTGAVRVDLTAETAEISAVPGGPVETGGCPESVACVMFTSGSTGLPKGVAASHRALAATFVGPDYLAFGPQQTFLQCSPVSWDAFALEVFGPLLHGGVCVLQPGQHTDPHQIVELVERHQVTTLQMSASLFNHMLDEHPAVFGQLREAMTAGEAASPSHTAQALARFPHLRLLNGYGPAESMGFTTTYTIEPGTAEGVASIPVGGPLSGKHTYVLDANLELVAPGVPGELYVAGHGLAHGYIGQPGLSADRFVANPHGPAGSRMYRTGDLARWSRDGEIEYLGRADQQVKLRGFRIEPGEIESALVAHPSLSQAAVVVREDRPGDKRLVAYVVGDTADSAALLRHTAARLPEYMVPAAVVVLDELPRTVNGKLDRRALPAPDLSAACEGRAPRNPAEEILCGLFADTLGLASVTIDDHFFHRGGHSLLATRLISRIRTVWDTRVTIRDLFQSPTPALLAEHIAAGSGGNPLDTVLPIRAAGRDTQAAPCSACTPSPG
>NZ_CP013743.1|WP_058920511.1|252524_252959_-|hypothetical-protein
MKHPHPPDRIDVAAGLRRILQDLSAVERWAEGDGAAPPVPYADEEPWEGPEFSVETVSDSGMHTVVDIVPRRCPGSLQTGRERPGEDEVAALRSTVRALLDLADVGSGRAWTTVVLTKRGPRVVSCRLGAGETVYAREPVLGRD
>NZ_CP013743.1|WP_058920512.1|253464_254271_-|ABC-transporter-permease
MTSSAASLIPVNIPLGILLAVLLLVAAAVAGKFHLDPHPYRSRAREILVAGVRAAVQLAVVSVVIAWAVKSVLGLVAFLLVMSCVAVRTAGRRITGNNTWWLTAAPIGAGVMPVVAVLLLTGLVPLKGIALIPITGQLIGGALTVTVLAGRRALDELAQRHGEVEAAMALGFLDRDARMEIARPAASDALLPGIDQTRTVGLVTLPGAFVGMLLAGAGPVMAGAVQLFVLIALMAVQSIAVAVTLELVARHRLHRLPRAPRLPAKEAT
>NZ_CP013743.1|WP_058920513.1|254413_254713_-|MarR-family-transcriptional-regulator
MNEHSAGWAFLTSHARVLLTIARDGDLRLRDIAAACHITERAAQGIVTDLERAGYLSRERDGRRTRYTLHLHGTLHHPAEVHLPVRGLLALLTPSGGER
>NZ_CP013743.1|WP_058927851.1|254922_255345_+|ATP-binding-protein
MVGEAFEGSENISAARRLALSFLADVHQVHGVPVSDRATGGVQLVVSELVTNARKYAPGPCLLTLEVKEGVVEVTVWDSNPSLPVAQAADPDRVGQHGLEIVMALCQSFQMHREPVGKRIVAAITLADDPVGDVAATQIG
>NZ_CP013743.1|WP_058920514.1|255606_257376_-|hypothetical-protein
MGVAGGLERWLGLRLERVPGWVAGVLGVVCVAVGLVLLVRPFRSLSVLLVVMAFAAAVMGVSAVAQSGHAPRRWVQVAVGVVWLLLSAALVAVPAISLGLLSVVAGIGLVVEGVLSVIAAVRDQSDARVAGVLQGAAGIVFGVLAVMWADVTLLVVAVIFGARTVLFGCSTVLAAVHRARGVDRRPARRRPRWMRTVGAGLSLLLAVVLALVSAVVHRGEPSVTAFYTPPSTVPDRPGQLLRSEAFDRDVPAGAAGYRILYTTTRADGRPAVASGIVLAPRGSGGPSPVVAWAHGTTGVDTTCAPSLLEHPFKAGALPALGGVVKAGWALVATDYVGLGTRQPHPYLIGQGEARSVLDAVRAARQLHTVKLSDKTVVWGHSQGGHAALWTGQVAASYAPDVPLAGVAALAPASDLRALVSNLDTVPGGAIFASYVFTGYRDHYPDVTAGEYLRPAARGLVREWAGRCLAEPEVFASITTSLMLDKPIFSRSPLTGAFERRLTDNTPRGRIAAPVLIAQGGSDPLVLPAVQRAYARTACAAGNRIDYRTYPGLDHNGIIGDGSPLLPQLLAWTADRFQGRPAAGTCPIRS
>NZ_CP013743.1|WP_058920515.1|257689_257929_+|hypothetical-protein
MIVRRLHDAGVTSEHAYTAAAASIGLSLVSWLASSRTENVERADRWGIFVGEWAPTFFALGLALANYEQRAEDAGRTAV
>NZ_CP013743.1|WP_058920516.1|257925_259080_+|serine/threonine-protein-phosphatase
MTSGGPRKAARPAARTVRHAWLLGAVFALIVSVTVVDILTPPEVHLGPFLVAAPAVTASFAGPRLTGFVGAVAVLAQAAVAIVRTSLTDLNHTYQIIALILISALATLFASLREREEQRVARLRSIAHTAQSVVLRPLPERAGPLVIASLYLAAQEEAHIGGDLYAAARTPNGTRLLIGDAKGKGLDAVSEASLVLGAFRVTAGRTHELPELIAHLDAAVGSAQDTGTTDAGDAASACPGSGMWWEAFVTALVLEIPDDESVVHIVSCGHPPPLLLRDGRVLPLDGVEAGLPLGLSDAAPPRVTVHTFPFGGGDALLLYTDGVIETRNPQRNFYPLTERLDTRSDHAPQALIDHLKADLQSFAGGHLGDDAAFVAVQRLHRHSE
>NZ_CP013743.1|WP_058927852.1|259456_260134_-|alpha/beta-fold-hydrolase
MTTFVLVPGGWRGGWYFSGLADRLRTAGHRALAITPTGVGDRAHLNAADVNLDTHIDDVLAVLATEEVSDAVVVGHSYGGMVITGAADRAPSGVVRRLVYCDAYVPEDGQSCWDLTSDAYRSVFLDGAAADGYTVQPRPGSDPRVTAHPLASFLQRIRLDGAGLREVTTRDYVYLSGWDGTPFTAVRDRLSHDPAWRVHTLHSGHDVCRDAPREFLEILLLGEEP
>NZ_CP013743.1|WP_107416234.1|260247_261789_-|serine-hydrolase
MSTAAAVGCATASLATAPPAAASPRSAPQGGGTGDTANPLFSALDAKIEEGMRAYAIPGAAVGVLLNGQEYIRGYGVTNVDHPVPVDGDTVFRVGSTTKTFTGTTLMRLAEQGKVELDAPVRRYLPDFAVADPFASAQVTVRQLLNHSAGWLGDDYQDFGQGDDALTRFVASMARLPQLTEPGTVFAYNNAALCVAGRIIEAVTGKTYEAAVRALVIDPLGLGHTRFSSDEIVGFNVAASHDVVDGKAVLEPSFWPQPRSLAPTGGLISSVRDQLNWARFHLGDGTAPDGTRLLSRPSLEAMRSRPGPGGTLVVELDGMGVTWMLRPSAQGRRIVQHGGTWPGQISGFLMVPSRGFALTLLTNSEGGTGLRDELFTDDWALSRYAGVTNLPATAETLNAQELKPYEGRYMAQRINEEGAVEDVVMELTRRNGRLHATQTAHGPAGQDDAASEEEDSAQDQSTELQAAFYKQDFALDLDAEGQPIGTRSDFVRGPDKTVLWWRNHGRLYRHQTP
>NZ_CP013743.1|WP_079078342.1|261881_263453_-|alpha/beta-fold-hydrolase
MRWDSVYDLNRQTIEHEALRHGYPSSDRGHWIFPGTLLTLPPPQAARAQPSRFVPAACPTTYGELKDTRCGFLVVPENRARPSSRTLRLAVARVRSASPTPHADPIVFFTGGPGADALADIAGLTEAGLNRDRDLIVLSQRGTYSSERPLTCPEIDRFYGERVHLLYDAPSTGDLYAQAAARCHDRLTAQGIDLAAYNTSENAADAADLRTALGIGQWNVLSHSYGTQLALTYMRMFPKGVRSVTVDGVVPPSVATPGWTWSSMRESFDNIVSACAAQPSCRQHYPGIGATYLRMVRRLEAHPVTTHVTVPQVGRVKVVLDGGALLNWMVRASHAPETFAVGVDELAHGRPERIAQQWASAWLPGSQGMFAHGFSLSVWCSEWVPFETSQEQLAKGRQAFPELPRSVLAQAPQLPFLRQACQAWNVPKAPDSVREATSSSIPTLAISGSFDAQTGAQWGRYVARTLSRSTVVTLAGVAHGAFDNPCGAKVITSFFDDPEHPDTRCVNTVKPAPFAIGSEGAGK

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Crispr_ID: NZ_CP013743_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_2

3431667-3431741

Orphan

Consensus_repeat	Method
TGGGGCTCCGGCATGATGGGCAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013743_2

>merge|NZ_CP013743|2|3431667-3431741|CRISPRCasFinder
TGGGGCTCCGGCATGATGGGCAACGACAATGGCTCATGGGGCCCCGGCATGATGGGCTCCGGCATGATGGGCAAC

>NZ_CP013743|2|2|3431667-3431741|CRISPRCasFinder
TGGGGCTCCGGCATGATGGGCAAC	GACAATGGCTCATGGGGCCCCGGCATG
ATGGGCTCCGGCATGATGGGCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_058922890.1\|3441365_3443324_-\|copper-resistance-protein-CopC/CopD	unknown	unknown	gnl\|CDD\|377255
NZ_CP013743.1\|WP_058922873.1\|3423266_3423719_+\|DUF3093-domain-containing-protein	unknown	unknown	gnl\|CDD\|378627
NZ_CP013743.1\|WP_058928144.1\|3428110_3428386_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225993
NZ_CP013743.1\|WP_058922877.1\|3429161_3430796_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP013743.1\|WP_058922878.1\|3430816_3431188_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058922872.1\|3422660_3423224_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238449
NZ_CP013743.1\|WP_058922875.1\|3426038_3426986_+\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
NZ_CP013743.1\|WP_079078441.1\|3439623_3440271_-\|DUF305-domain-containing-protein	unknown	unknown	gnl\|CDD\|367619
NZ_CP013743.1\|WP_058922888.1\|3440246_3440927_-\|DUF3105-domain-containing-protein	unknown	unknown	gnl\|CDD\|378632
NZ_CP013743.1\|WP_058922876.1\|3428470_3429169_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP013743.1\|WP_058922879.1\|3432304_3434218_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377255
NZ_CP013743.1\|WP_058928143.1\|3427002_3427413_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP013743.1\|WP_159104166.1\|3440991_3441363_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058922874.1\|3423722_3424544_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058928146.1\|3434217_3434724_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058922883.1\|3436737_3437613_-\|exo-alpha-sialidase	unknown	unknown	gnl\|CDD\|271234
NZ_CP013743.1\|WP_058922886.1\|3438940_3439585_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_CP013743.1\|WP_058922885.1\|3438583_3438835_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058928142.1\|3424474_3425218_+\|DUF1775-domain-containing-protein	unknown	unknown	gnl\|CDD\|377951
NZ_CP013743.1\|WP_058922884.1\|3437642_3438407_-\|cytochrome-C-biogenesis-protein-ResC	unknown	unknown	gnl\|CDD\|280792

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_058922873.1\|3423266_3423719_+\|DUF3093-domain-containing-protein	gnl\|CDD\|378627	pfam11292, DUF3093, Protein of unknown function (DUF3093). This family of proteins with unknown function appears to be restricted to Actinobacteria. Some members are annotated as alanine rich membrane proteins however this cannot be confirmed.	1.34635e-45
NZ_CP013743.1\|WP_058928144.1\|3428110_3428386_+\|hypothetical-protein	gnl\|CDD\|225993	COG3462, COG3462, Predicted membrane protein [Function unknown].	1.2944e-09
NZ_CP013743.1\|WP_058922877.1\|3429161_3430796_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.04667e-70
NZ_CP013743.1\|WP_058922872.1\|3422660_3423224_+\|hypothetical-protein	gnl\|CDD\|238449	cd00884, beta_CA_cladeB, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	1.23589e-33
NZ_CP013743.1\|WP_058922875.1\|3426038_3426986_+\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	3.04699e-110
NZ_CP013743.1\|WP_079078441.1\|3439623_3440271_-\|DUF305-domain-containing-protein	gnl\|CDD\|367619	pfam03713, DUF305, Domain of unknown function (DUF305). Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	1.414e-44
NZ_CP013743.1\|WP_058922876.1\|3428470_3429169_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.19508e-81
NZ_CP013743.1\|WP_058922879.1\|3432304_3434218_-\|hypothetical-protein	gnl\|CDD\|377255	pfam04234, CopC, CopC domain. CopC is a bacterial blue copper protein that binds 1 atom of copper per protein molecule. Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm.	2.47483e-24
NZ_CP013743.1\|WP_058928143.1\|3427002_3427413_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.1934e-27
NZ_CP013743.1\|WP_058922890.1\|3441365_3443324_-\|copper-resistance-protein-CopC/CopD	gnl\|CDD\|377255	pfam04234, CopC, CopC domain. CopC is a bacterial blue copper protein that binds 1 atom of copper per protein molecule. Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm.	2.09775e-19
NZ_CP013743.1\|WP_058922888.1\|3440246_3440927_-\|DUF3105-domain-containing-protein	gnl\|CDD\|378632	pfam11303, DUF3105, Protein of unknown function (DUF3105). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	2.04643e-60
NZ_CP013743.1\|WP_058922883.1\|3436737_3437613_-\|exo-alpha-sialidase	gnl\|CDD\|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	2.86465e-05
NZ_CP013743.1\|WP_058922886.1\|3438940_3439585_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	9.96891e-22
NZ_CP013743.1\|WP_058928142.1\|3424474_3425218_+\|DUF1775-domain-containing-protein	gnl\|CDD\|377951	pfam07987, DUF1775, Domain of unkown function (DUF1775). Domain found in bacteria with undetermined function. Its structure has been determined and is an immunoglobulin-like fold.	1.66349e-12
NZ_CP013743.1\|WP_058922884.1\|3437642_3438407_-\|cytochrome-C-biogenesis-protein-ResC	gnl\|CDD\|280792	pfam02683, DsbD, Cytochrome C biogenesis protein transmembrane region. This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange proteins. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.	3.12335e-37

>NZ_CP013743.1|WP_058922878.1|3430816_3431188_+|hypothetical-protein
MTRNQRKRTILAAAVLAPALALTGGLAYAANNGDGDTAPAHPTGTSATPTARPDRTTTPTHRDDCRHGYRTPGTGSGYDHRQTAPSTGGGNRSGWGPGDCGDHPWGYTQGNGYSSSHGYDDCH
>NZ_CP013743.1|WP_058922877.1|3429161_3430796_+|HAMP-domain-containing-histidine-kinase
MRRRLRGGLPARSFAFRLGLAFALVALVGASATALVVNAAFASRFRQYAEQQQHARVTGITAAAGQSYAGNQQWDLRALQALSSAAGTASVRILTPSGQDVWRWDGHEMSWNGQWMEDDQDDQGGDSGTGSGGGQGDCGSWDHCGPGNMSDSRESGDGHSGMPDAAATAASAVVWPVADTTPTPGPSSPSGLGTAQRLPMTSGGKVVGTALVRLPKAASLPDAIAFRDRVVGMVLLGGATGAVLAAALGTLLARHSTRPVRRLTAAARALAAGDRHTRLDTSRGDEFGEMTRAFNTMADAAEGAERLRQEFASDVAHELRTPLTILRSQVEGMRVGVLDAGPDALTSLDEEVQRMTRLVADLQILGAADAAGFTLERAPTPLQDLAEQAVREFAGLFEASEIQLHTRLDPVTACVDRDRVRQILANLLSNALKFTPAGGQVRVDLFTEAKQAVLCVGDSGPGIPTDELPHVFDRFFRGRGARPAGSGIGLAVVRELTQAHGGTVQVSSAPGQGTTFTVRLPLEATSPPNRFHTDPSQPPPSVKS
>NZ_CP013743.1|WP_058922876.1|3428470_3429169_+|response-regulator-transcription-factor
MGTATVLVVDDERKIRDTVRAFLERERYAVLTTGSGQEALDVALRLKPDLVVLDLMLPDLAGEEVARSLRAISRVPIIMLTAKASEAERVAGLQLGADDYVVKPFSPLELVARVDAVLRRARPGGAEGLLSFGGGELVIDPAGREVRLDGAEVALTRSEFDLLAALVTTPGRVFSRRELVARVHGYDYGGYERTADVHVKNLRAKLGDDPKEPRWVLTVPGVGYKFRARPDA
>NZ_CP013743.1|WP_058928144.1|3428110_3428386_+|hypothetical-protein
MWDDGGWGWGGGFVMALLTLLFWAMVIAGVVVLVRYLTGSRHGRQSGPPPSAGEPGWGSRQAEDLLAERFARGEIDEDEYKRWLALLREHR
>NZ_CP013743.1|WP_058928143.1|3427002_3427413_-|universal-stress-protein
MVVGIDGSPVSEKALRWAVEETRLRAATLRVVHAWSSPYHGSEIARRASDAMHGPLERAAEETIDAALGHIVDTDLAVERRVVESLPAQALIEAARGADLLVVGARGHGGFADLLLGSVSHQCAQHAPCPVVIVHG
>NZ_CP013743.1|WP_058922875.1|3426038_3426986_+|cation-transporter
MAHDQRDSSTPGVPGGDGHVHGPRMGSAGGRHQKPLTIAFLLTAAYALVEVVGGIVTGSLALISDAAHMGTDVLGLGLALAAIHFSKRPAAGQRTYGTYRLEVLAAVINGLLLFGVAFYVLYEAVQRFRNPPEVLGAPMLVVASVGLLVNVVSFRLLNGGAKESLNVKGAYLEVLSDMLGSIGVILGAIVITVTGFRYIDAIVAAAIGLFILPRTWQLMRQALRILMEVAPPGVDVEAAARDLAAVPGVREVHDLHIWTLTSGMEAATAHVVIENGADWHAVLDRTRQILAERYGVTHPTVQIEPAEHVEDPAGF
>NZ_CP013743.1|WP_058928142.1|3424474_3425218_+|DUF1775-domain-containing-protein
MPTSVHPVARAGRRIALAGAAALTATLALAAPASAHAEVEADTPQALAENVTLSFVSEAESDSAGFTQLRIVLPDGIAPGDVTLDEAPKGWKLKTTSGGYSVAGPALKAGVDAEHKIKIRQLPDAKEIAFKTVETYSDGKISRWIELPTGGAEPEQPAPVLKLKAAAPGAKAVSPSPSATESATPSPAPTATESDIAAAGSDTDAKAAEVDDDSSTGVIIGVVLAALAILGAGVWWLVQRRNASSQS
>NZ_CP013743.1|WP_058922874.1|3423722_3424544_+|hypothetical-protein
MTVPREGVTGHEVRAGAGRASCAGTCARAGLFAVLGTVLATFGHHAIAEGTVPWRLVGASNVAQFVAVWPLARCRYTPAATVLCTLAVQGALHLALSYADSDPPAAMTGHTMHAGHGTGAVGDGHAWHHAGAAMTAVHVVAALVVAWLLCRADARMTAALGTLGTLAKTAVAALAQVLLRPFFDTARLGFALPHRRPGASFEVAAPAWADVLEHAVVRRGPPRREHLQSVTRSRLLRDRFFPYQQGVPLCPSPRPFTRWPAPAAVSRSPVPPL
>NZ_CP013743.1|WP_058922873.1|3423266_3423719_+|DUF3093-domain-containing-protein
MASPTRLVYDERLTAPRTWWLIAVLFGLSLALVFMPYGLIAALIALMIGTCLAGMYVSAQGSTRIRVTEDTLFVSDARIPLAALGQPEVLEGEEARAWRTYKADLRSFMVMRSFLPSAVRVEVVDPDDPTPYLYLASRTPERLAAALGRE
>NZ_CP013743.1|WP_058922872.1|3422660_3423224_+|hypothetical-protein
MQYLIDQARVFRARAAAHSLHLDGLAQQHRPRAMFISCSDARLVPALLTAARPGDLFELRTYGGVVPPYDTKTPTSESRTIGYAVDVAVSDIVVCSHSHCAVVTAAMSDNRTVSGVTGCDADAAPLTGDVTAAGHWHVLTQLDALANYPCVVPRLADRSLRLHAWFHELDTGATLHYHPRASAFLPL
>NZ_CP013743.1|WP_058922879.1|3432304_3434218_-|hypothetical-protein
MTAAPVPTATRRARTPLTALLLLGAVLALLLGGAGTASAHATLNRSDPTDSAVVKTAPKQITLTFSEAVTLSDGSLRVLSPKNLRVDRGPVGHAAGKADTARVTLAGKLPEGTYTVAWRAVSSDSHPISGAFTFSIGQPSATSAALPTDSPEDTAASRLYGFFRYVAYGGLALFIGGAVFTLGCWPAGAGLRPLRRLLLSGWTALFASTVVLLLLRGPYETGRGVTAVFDPSLLGSTVVGRTGVALGMRLLLLAVAGILFARFTRFARFARFARFATRLGAGARAVGALLAVGLALTWATAEHASAGLQVPLAIPVAVLHLLAMAVWLGGLLALLVVLFRAPADEVIPVEAVTRFSRLAVATVVVLAATGVYQSWRQVGSFAALSTTEYGRLLTLKIAAVVLVLTAAAFSRQWLDRLTGEQSTETLSAAASQPVRVAQTVGAGTSSGGGTAGAAEAPVSRGLPDTPEPSASDTHRRALRRSVAVDAVLGVVVLAITTLLTGTQPSRAAIANAAAVAAAQQPTARVVMVPFDVGTPNGHGTVQLTFAPGRVGDNTVEAVAYGPDKGFVTVPELRLTLTQRAQRIGPLDAKLVDRKGYWATDRLRLPLAGTWTLRLTVRVTDVDQVTVTKDVTIRPSPG
>NZ_CP013743.1|WP_058928146.1|3434217_3434724_-|hypothetical-protein
MRRRDVPHHPQTERTGRLVRGAALAASLALVPLTAACSGGGDDDGAAERKQAKISVTAAPAAGVVAPAKVEVIATLTGCKPKIRINATELRQGVCHTKKVDYLVTTFPTDELKETFLESASMYGGKYLVGPRWIVSAQPEKLPGFRDKLGGTIRELRGMGPTAAPSAS
>NZ_CP013743.1|WP_058922883.1|3436737_3437613_-|exo-alpha-sialidase
MKTRRRPLVAVTGTLLAAVLTAACSSGSDTAAKHTADDGLVVSHVHGLGIDPADGRLYVATHQGVIAVPEKGSAKRVGDKADYMGFTVIGPKTFLGSGHPAEGSGGDADRGLIESTDAGKTWKSLSLAGTTDFHALKYAHNTVYGYDSTSGVLRVSTNRTTWDTRAQLAALDIAVSPKDSKLVLATTEAGIAKSTDGGKTFGKGSGQILAFLSWPKADALYGVDLAGGLHRSTDNGGTWTKTGTVPGGQPQALTALDADHILAAAQNGVYESRDGGRTFTKRLAISAGMGH
>NZ_CP013743.1|WP_058922884.1|3437642_3438407_-|cytochrome-C-biogenesis-protein-ResC
MSVTDTVSSGPLLLAAPIALAAGAITVASPCCLPLVPGYLSYATGMTGTDVEASQVDGRIRRRALLGTALFVSGFAALFAAYGAFFGSLGNVLLAQQDIITRVLGALTILLGLMFMGALDRVPLLSRTFKPRFTPRAGLASAPLLGVMFGLGWTPCIGPTLAAVISLSMSTGSASRGAFLSFLYAMGIGIPFLLLTFALGKSLRVLSFTRRHARAVTVIGGGLLVLVGVLQVSGAWTWMISQLRYWTGTYQLPL
>NZ_CP013743.1|WP_058922885.1|3438583_3438835_+|hypothetical-protein
MRELLYVLPALACPIGMGVMMWLMMRPHRDGAPKASGPSPNPPLSTDQPEAPHDVAALRKEIAGLRAELDRRSADPPAVERTP
>NZ_CP013743.1|WP_058922886.1|3438940_3439585_+|class-I-SAM-dependent-methyltransferase
MTTTGRKELQHPRFARQYLKIAVESDRRGGTAHRDRLLAGLTGRMLEVGAGQGRNFRHYPDTVTEVVALEPDDTLRAVAEQAAGSSDVRVTVVPGEAAELPGKDGEFDAVVASLVLCSVTDVPAALAEIARVLRPGGELRFYEHVRSPRRWAGWLEDAITPLWSRAGGGCHPNRDTEAAIRAAGFTVTEIDRFGFSFSPFLPNTLHIVGTAVRP
>NZ_CP013743.1|WP_079078441.1|3439623_3440271_-|DUF305-domain-containing-protein
MHGREVLVTGRLSRLLIAVAFGAVLAAGAVTAVLLWPASSTASATPDRESADAGFARDMAVHHQQAVELSFIVRDRTDDEEVRRLAYDVINTQANQRGMLLGWLDAWDLPKSSQQPPMTWMGHGSMHEAHDGSLMPGMATNAQMDKLRKADSKQAEILYLQLLTAHHKGGITMSEAAAGMAKTEQVRRLARGMVEGQESEMRLMADMLKERGATA
>NZ_CP013743.1|WP_058922888.1|3440246_3440927_-|DUF3105-domain-containing-protein
MASASSRNSNASKGNKNKPSSKAKADARRARIEEQRRAERARERRNRIITIVASTAILAGLVGGGWYLVDSANQKEQGKAAPISGEKTWSKLSRNHVTTTVKYPMTPPVGGNHAPVWQDCNGNVYTQPLQNENAVHSLEHGAVWVTYNTKAADADVKALAAKVKKTPYTLMSPYPSESAPITLNAWGHQLKVNKASDPRVDEFLSKYVQGKQTPEPGAACTGGKSS
>NZ_CP013743.1|WP_159104166.1|3440991_3441363_-|hypothetical-protein
MSVRRRSGAVVLGLLVALATLLGVACLCSHGHALQAEPVAVASVSYDGPHHHARDHACLSPGHDHCGAKLSVDTPTTGPGPHPQPLGLPVRVDPRPILAPTATTWYAAAPRAPDLHVLQVLRT
>NZ_CP013743.1|WP_058922890.1|3441365_3443324_-|copper-resistance-protein-CopC/CopD
MFKVWGGSVRRSVRLVVALVLALAGLLVGAPASQAHAVLLFASPSIEGAVPTAPQSISLVFDEPVQPSGSRTVRLTTSAGRSVAVGTASRSEGGRQLAVPVRGMLEPGVYTLAWQATAQDGDVMGGSYRFAVGSAAAGLSAGSAGGQQQVSGAGTTGVLRWVLFAAFALTLGGLVGERLAARQGIRSPRPWLRTGAVSGLVASLGLAVLIAGGGSLVEGVSSPSGSALFGGRAGALAVVESAGWLLAAVALFRGWRPSAWTGLAAAVVSEGLRAHPAGASSVWGPVLTTVHLASAAVWIGALVYLVWVGIARRWDAGFRRALAGYARLALVLVVAVLLTGTLSGLLLVSPSELLDTSFGKVLTVKLTLVVAVCALATLARRRMAQAAPRSLVRVEASALVAILAVTAWLSVTQPPRDAQATLPFAPPATGDAITVGGRADQIGIAATASAGQVVLRLTAPTTDLERGDSRSYRASLRLADAAGKARTLTLRGCGEGCFYAPVTWKNGANLLTVRAEAKDWGGGKDSLRVMWPVRPDTALLERTVKAMRAVKQLTVHEQVASDTARLGVAPTLLKVSGAHFVDSEPYAQGKATQTSRFTDAEGHTVLALGYPGERLALELTLDDHDRLVRETLVAPNHFIRRSFTYPEPEGSG

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Crispr_ID: NZ_CP013743_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_3

4085383-4085620

Orphan

Consensus_repeat	Method
CGGAGACCACCCCGCGCCGCCGCACCCGCAAGGCCGCGGCGACCCCGGA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP013743_3

>merge|NZ_CP013743|3|4085383-4085620|PILER-CR
CGCCGCCGCACCCGCAAGTCCGCGGAGCCGACGGTGGTTTCGGCCGAGACGGCCGTCGCCGAGACCCCGGCGCCGGCGGTCACGGAGCCCGAGGCGCCGGAGGCCACGCCGCGCCGCCGTACCCGCAAGGCGACGGCGGCCGCGGAGACCGTGCTGGACACGGCCGAGTCGGCCCCGGAGACGGTGGCGGAGACCACCCCGCGCCGCCGCACCCGCAAGGCCGCGGCGAGCCCGGAGA

>NZ_CP013743|3|1|4085383-4085620|PILER-CR
CGCCGCCGCACCCGCAAGTCCGCGGAGCCGACGGTGGTTTCGGCCGAGACGGC	CGTCGCCGAGACCCCGGCGCCGGCGGTCACGGAGCCCGAGGCGCCGGAGGCCACGCCGCGCCGCCGTACC
CGCAAGGCGACGGCGGCCGCGGAGACCGTGCTGGACACGGCCGAGTCGGCCCC	GGAGACGGTGGCGGAGACCACCCCGCGCCGCCGCACCCGCA
AGGCCGCGGCGAGCCCGGAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_079078452.1\|4082612_4083350_-\|tRNA-2-methylthio-N6-isopentenyl-adenosine(37)-hydroxylase-MiaE-like-protein	unknown	unknown	gnl\|CDD\|205967
NZ_CP013743.1\|WP_058923378.1\|4073762_4074761_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP013743.1\|WP_058923388.1\|4089065_4089671_-\|MarC-family-protein	unknown	unknown	gnl\|CDD\|225006
NZ_CP013743.1\|WP_058923381.1\|4077769_4079338_-\|DUF3152-domain-containing-protein	unknown	unknown	gnl\|CDD\|371483
NZ_CP013743.1\|WP_058923385.1\|4081840_4082068_+\|DUF3107-domain-containing-protein	unknown	unknown	gnl\|CDD\|378634
NZ_CP013743.1\|WP_058923380.1\|4075748_4077467_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173871
NZ_CP013743.1\|WP_058923383.1\|4080565_4080790_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058923382.1\|4079345_4080392_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP013743.1\|WP_058923390.1\|4090686_4091328_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058923389.1\|4089719_4090577_-\|PHP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223686
NZ_CP013743.1\|WP_058923384.1\|4080995_4081640_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP013743.1\|WP_079077986.1\|4086772_4087651_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|274729
NZ_CP013743.1\|WP_058923394.1\|4095009_4095522_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058928192.1\|4087672_4088566_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350235
NZ_CP013743.1\|WP_058928190.1\|4082286_4082556_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058923393.1\|4093855_4094986_+\|magnesium-and-cobalt-transport-protein-CorA	unknown	unknown	gnl\|CDD\|213364
NZ_CP013743.1\|WP_058923392.1\|4092762_4093347_-\|suppressor-of-fused-domain-protein	unknown	unknown	gnl\|CDD\|377450
NZ_CP013743.1\|WP_058923391.1\|4091494_4092721_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NZ_CP013743.1\|WP_058923395.1\|4095527_4096271_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058923379.1\|4074757_4075744_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_079078452.1\|4082612_4083350_-\|tRNA-2-methylthio-N6-isopentenyl-adenosine(37)-hydroxylase-MiaE-like-protein	gnl\|CDD\|205967	pfam13794, MiaE_2, tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like.	9.88409e-96
NZ_CP013743.1\|WP_058923381.1\|4077769_4079338_-\|DUF3152-domain-containing-protein	gnl\|CDD\|371483	pfam11350, DUF3152, Protein of unknown function (DUF3152). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	1.9084e-73
NZ_CP013743.1\|WP_058923382.1\|4079345_4080392_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.94027e-27
NZ_CP013743.1\|WP_058923388.1\|4089065_4089671_-\|MarC-family-protein	gnl\|CDD\|225006	COG2095, MarC, Multiple antibiotic transporter [Intracellular trafficking and secretion].	3.28587e-41
NZ_CP013743.1\|WP_058928192.1\|4087672_4088566_-\|NYN-domain-containing-protein	gnl\|CDD\|350235	cd10911, PIN_LabA, PIN domain of Synechococcus elongatus LabA (low-amplitude and bright) and related proteins. This subfamily contains Synechococcus elongatus PCC 7942 LabA which participates in cyanobacterial circadian timing, it is required for negative feedback regulation of the autokinase/autophosphatase KaiC, a central component of the circadian clock system, and appears to be necessary for KaiC-dependent repression of gene expression. This subfamily belongs to the LabA-like domain family which includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Also included in the LabA-like domain family are human ZNF451, uncharacterized Bacillus subtilis YqxD, uncharacterized Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously Pseudomonas putida S16 NicB , which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.44998e-06
NZ_CP013743.1\|WP_058923385.1\|4081840_4082068_+\|DUF3107-domain-containing-protein	gnl\|CDD\|378634	pfam11305, DUF3107, Protein of unknown function (DUF3107). Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.	6.54875e-36
NZ_CP013743.1\|WP_058923380.1\|4075748_4077467_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173871	cd08506, PBP2_clavulanate_OppA2, The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold. Clavulanic acid (CA), a clinically important beta-lactamase inhibitor, is one of a family of clavams produced as secondary metabolites by fermentation of Streptomyces clavuligeru. The biosynthesis of CA proceeds via multiple steps from the precursors, glyceraldehyde-3-phosphate and arginine. CA possesses a characteristic (3R,5R) stereochemistry essential for reaction with penicillin-binding proteins and beta-lactamases. Two genes (oppA1 and oppA2) in the clavulanic acid gene cluster encode oligopeptide-binding proteins that are required for CA biosynthesis. OppA1/2 is involved in the binding and transport of peptides across the cell membrane of Streptomyces clavuligerus. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	6.12026e-179
NZ_CP013743.1\|WP_058923378.1\|4073762_4074761_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.76571e-95
NZ_CP013743.1\|WP_058923389.1\|4089719_4090577_-\|PHP-domain-containing-protein	gnl\|CDD\|223686	COG0613, COG0613, Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only].	1.15238e-51
NZ_CP013743.1\|WP_058923384.1\|4080995_4081640_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	8.74765e-17
NZ_CP013743.1\|WP_079077986.1\|4086772_4087651_+\|alpha/beta-hydrolase	gnl\|CDD\|274729	TIGR03695, menH_SHCHC, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase. This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	1.02908e-14
NZ_CP013743.1\|WP_058923393.1\|4093855_4094986_+\|magnesium-and-cobalt-transport-protein-CorA	gnl\|CDD\|213364	cd12830, MtCorA-like, Mycobacterium tuberculosis CorA-like subfamily. This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	3.84883e-171
NZ_CP013743.1\|WP_058923392.1\|4092762_4093347_-\|suppressor-of-fused-domain-protein	gnl\|CDD\|377450	pfam05076, SUFU, Suppressor of fused protein (SUFU). SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.	3.22816e-29
NZ_CP013743.1\|WP_058923391.1\|4091494_4092721_+\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.20099e-89
NZ_CP013743.1\|WP_058923379.1\|4074757_4075744_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.85951e-74

>NZ_CP013743.1|WP_079078452.1|4082612_4083350_-|tRNA-2-methylthio-N6-isopentenyl-adenosine(37)-hydroxylase-MiaE-like-protein
MTTPDNTPDAPAEHTGVAAQDWATASAEPQYRAAVVDLLGALAYGELAAFERLAEDAKLAPTLADKAELAKMASAEFHHFERLRNRLTEIGEEPTGAMEPFVAALDGFHKQTAPSDWLEGLVKAYVGDSIASDFYREVAARLDSDTRELVLAVLDDTGHAGFAVEKVRAAIDAEPRVGGRLALWARRLMGEALSQSQRVVADRDALSTMLVGGVADGFDLAEVGRMFSRITEAHTKRMAALGLAA
>NZ_CP013743.1|WP_058928190.1|4082286_4082556_+|hypothetical-protein
MLIEALGSALLGLVLAWTANRRLGHRLPARSLVLATGVAGALFGAFLTHSAFDPGNSLLVLIGAAIVSAASLSLLLRPAGRLRRRQAPA
>NZ_CP013743.1|WP_058923385.1|4081840_4082068_+|DUF3107-domain-containing-protein
MEVKIGVQHAPREIVLESGQSAEEVERIVAEALAGKSQLLSLVDEHGRKVLVPAERLAYVELGEPAPRKVGFGAL
>NZ_CP013743.1|WP_058923384.1|4080995_4081640_+|TetR/AcrR-family-transcriptional-regulator
MTAIEQTEAARPRGTRLPRRARRNQLLGAAQEVFVAQGYHAAAMDDIAERAGVSKPVLYQHFPGKLDLYLALLDQHCESLIQAVRSALASTTDNKQRVRATMDAYFAYVEDDGGAFRLVFESDLTNEPAVRERVDKVTNECAEAICDVIAEDTGLSRAESMLLASGLGGLAQVVARSWLHSDRSVPRDQAVQLLTSLAWRGIAGFPLHGTDQNH
>NZ_CP013743.1|WP_058923383.1|4080565_4080790_+|hypothetical-protein
MTVDPTDPETFADEEARKASEFDVEAPENDAAEQQADLAPDQDDPLDDVDPARANEADVVEQRRVVSLDEDDYR
>NZ_CP013743.1|WP_058923382.1|4079345_4080392_-|alpha/beta-hydrolase
MSSTDLPSVPASNVLPKVAPVRVAEGERLRSVGLPGITLAIRSRPPAREGLPPALYVHGLGGSSQNWSALMQELEGVVDGEALDLPGFGDSPPPDDGDYSVTGHARAVIRHLDAAGRGPVHLFGNSLGGAVTTRVAALRPDLVRTLTLVSPALPEIRVQRSAVPTGLLALPGVAALFYRLTREWTAEQRVTGVMALCYGDPGRVTPEGFRHAVEEMERRLQLPYFWDAMARSARGIVNAYTLGGQHSLWRQAERVLAPTLLVYGGRDQLVGFRMARRAARAYRDSRLLTMPDAGHVAMMEYPDTVARAFVELLGETGQLPDGVTSRGRGSVGRGAVGEDETAAESAGS
>NZ_CP013743.1|WP_058923381.1|4077769_4079338_-|DUF3152-domain-containing-protein
MGRHSRRGSAPAAKGEAERERAGRGSRASQEPPGARERGTAQRADGAPARGVSRPSEGTPAGGAPRYADGTPARGIPRLPDGTPARGVPRFPDGTPARGVPQVRGGHPQQREPGGGWGELRGQGGSGRVPPAGRGPSHGPSTGTGSSTGTGSSTGTGPSTGTGSSTGAGPSTGRRPSAGPGVAIPRQRQEPRFGPRQDYLDAFDEEDESDDVFARRPGVTAHAAEPYPSAAGRTPRPGVGVPSETDEDEAPPTGVPAQTTGSKGRTFTGIAAAAVTTVLAVVVAGQVTHGRDDTGVGTQAATDQARDVRSTPSAAPSPSVATLTYEQAMGEKYALGATFRGPGKFDAVPGTDRAPGKGRKYTYRVDVERGLGLDGALFAEAVQKTLNDDRSWAHDGARTFERVDTTGKPDFVITLASPGTTATWCAKSGLDTTEDNVSCDSASTERVMINAYRWAQGSTTYGDRIHAYRQMLINHEVGHRLGYGHVTCSKSGQLAPVMQQQTKFLDHDGIHCLPNPWPYPRS
>NZ_CP013743.1|WP_058923380.1|4075748_4077467_-|ABC-transporter-substrate-binding-protein
MRHPSDIARRAAAASVGLVLAAGAAACGPKDNDAKGSAGDSAPHKGGTLTVLNSEPQTDFDPARLYTSGGGNVPSLVFRTLTTRNRENGAAGAKVVPDLATDTGRPSENATVWTYTLKKGLKYEDGTAITSADIKYGIERSFAPELSGGAPYLRDWLVGAADYQGPYKDKKGLSAIETPDSRTIVFHLNKPEGEFPYLATQTQFTPVPKAKDTGTKYAEHPVSSGPYKVVSNDNDGEHLVLVRNTYWSAATDAERKAYPDKVDVRSGLDSSVINQRLSASQGADATAVTTDTNLGPAELAKVTGDKELAARVGTGHFGYTNYIAFNPKVKPFDNAKVRQAISYAVDRSSVINAAGGSALAEAATTFLPNQKSFGYTPYDLFPAGRTGNAAKAKELLAQAGYKNGLTVTLTHSNSKGFETSPEIATALQDALKKAGITVKLQGLEDNDYRDKIHSVKTEPGFFLAHWGADWPSGGPFLAPIFDGRQIVKDGANFNNGLLDDKSVNAEIDAINKLTDLDAAAKRWGALDKRIGEQALTVPLFHPVYKRLVGKDIRNVVISDWTGVLDISQVAVK
>NZ_CP013743.1|WP_058923379.1|4074757_4075744_-|ABC-transporter-permease
MSEALVAVEVPGASASGTSGARQFRRRLRAQRAALVAASVVALLVLIALAAPLLTAIEGQDPTTYHPSLVDSARGGVPIGSFGGASAEHWLGVEPQTGRDLFARLVYGARVSLGVALGATAVQVLLGVVVGITAALGNRWVDQLLSRISDIIVAMPLMIMALALLAVVPGSFPRPVLVALIIGFVAWGTIAKITRAATLTLKELDYVAAARLSGWSTLRIARRELLPGLAAPVITYAALMVPVNIGIEASLSFLGVGVKPPTPSWGQMLSSADVWYQAAPQYLLLPAGALFVTVLALTVLGDGVRTALDPRTASRLRVGTGHKGEAKA
>NZ_CP013743.1|WP_058923378.1|4073762_4074761_-|ABC-transporter-permease
MTGFTGFALRRALGAIVTLLAISVIVYVVFYATPGDVAQITCGPRCSPAQVHQVAQQLKLDDPLYLRYWHFLQGVVAGQDYSTGTSTEHCSAPCLGLSYRSDRQVMQIILGKLPVSLSLVLGAMVLWLLLGVGTGVLSAWRRGRLTERALTGVTLAGVATPSFVIGLVLMIVVCGQLELLPFPEYVPLSADPEQWMWNLLLPWLTLALGEAAYFARLTRASMLETLAEDHIRTFRAYGVGERSIVGRHALRGALAPIIALNANDVGAMVGGAVLTETLFGLPGIGQELVHAVNVVDLPVVVGMVLVIGFFVVLANAVADVLYAVADRRVVLT
>NZ_CP013743.1|WP_079077986.1|4086772_4087651_+|alpha/beta-hydrolase
MSRPPTFTPPPGARAYALHTGRGEFAVVDAPVAAGVPERGTALLLPGFTGSKEDFNPLHAPLAARGYRTVAVDGRGQYESDGPAEDESAYAQEELARDVLAQAAALGTPLHLVGHSLGGQIARAAVLLDHSPFRSLTLMASGPAHISASQQERVKLLRDALAVMSMAEVWEAIRAMEAPEETDTGDLDAGLDDQEDLRRRWLGNKPAQLLATGRQLCVEPDRVAELAAVPLPFHVLSGERDDTWPVPLLDDMSRRLRAHRTVVEGAEHSPNTDRPLDTARAFADFWDATGAA
>NZ_CP013743.1|WP_058928192.1|4087672_4088566_-|NYN-domain-containing-protein
MNDDLAALTARIDRTNELLQRMLAEVAKTPSTHAIFVDAGYLYAAAGRLVAGTEDRRAFDLDAEGLIEALIDRARTIFADSRLLRVYWYDGARRRIHTAEQQSIAELPDVKVRLGNLNANNQQKGVDSLIRTDLESLARHRAISDAALLGGDEDLVSAVEAAQGYGARVHLWGIEAPEGRNQAEPLLWEVDSQRTLDLEFFKPYVARRTAPAYEAGTTRPTRENVRFVGAQIAAKWLAARGRESLVELLPGHPYLPGSVDQDLLVEAEGLLQYSLRGQADLRRALRDGFWDHLQTQY
>NZ_CP013743.1|WP_058923388.1|4089065_4089671_-|MarC-family-protein
MFDLAVFGSLFLTLFVIMDPPGITPIFLALTAGRPGKVQKRMAFQAVCVAGGVIAVFGVLGHQILDYLHVSVPALMIAGGLLLLLIALDLLTGKTDEPKQTKDVNVALVPLGMPLLAGPGAIVSVILAVQKADSVATQVSVWCAILAIHVVLWMVMRYSLLIIRIIKDGGVVLVTRLAGMMLSAIAVQQIINGVTQVIKGA
>NZ_CP013743.1|WP_058923389.1|4089719_4090577_-|PHP-domain-containing-protein
MRIDLHTHSTASDGTDTPAELMRNAAAAGLDVVALTDHDTTRGHAEAVAALPAGLTLVTGAELSCRVDGVSLHMLAYLFDPDEPALLAERELVRDDRVPRAQGMVAKLNGLGVPVTWEQVLRIAGDGSVGRPHVATALVELGVVPTVSDAFTPEWLADGGRAYVEKHETDPFEAIRLVKAAGGVTVFAHPGAHKRGRTVPEATIAELAAAGLDGIEVDHMDHAPDTRARLRGLAGELGLLVTGSSDYHGSRKTCVLGEYTTDPEVYGEITRRATGAFPVPGTGGA
>NZ_CP013743.1|WP_058923390.1|4090686_4091328_-|hypothetical-protein
MRGEPSCPKCGGRVRAPGLFADSWQCDVHGTVHPVQPVVPPSVEALSVVVHRTQVPVWMPWPLPVGWLFTGVACAGDDRHGGRATAVACSGPGPLGGMGELILVAEELGVGLGARYAGVEGPDPGPYLDVEKPPQTKVLAGGRPTPLWLVSGSPGDRAVFAGEALGLWLWAVVWPEQSGLLMYDELVLTDLRDAGAEIELVPCGALSPRLLKP
>NZ_CP013743.1|WP_058923391.1|4091494_4092721_+|MFS-transporter
MADPFDAGAGGILRQPKAVWATAGASVVAFMGIGLVDPILPSIAQGLDATASQVSLLFTSYFLITAVAMLLTGFVSSRIGGRKTLLLGLALVVLFAGLAGTSGSVGELVGFRAGWGLGNALFVSTALAVIVGAAAGGSAAAILLYESALGLGMACGPLLGAVLGNVSWRYPFFGTATLMAVGFLCITAFLKEQPKPARRTSILDPIRALGHGGLASAAASAFFYNYTFFTVLAFTPFVLNMTPYRSGAVFFAWGLLLAVFSVVVAPRLQARFGSLKVLGGSLVLLAADVLVLGYGDHTTAVVCTILSGAFIGVNNTVYTELALGVSDAPRPVASAGYNFVRWFAAAAAPYFAPKIEEWTDIHVPFVVAAVTALLGALVVLVRRRALTHDAEQLETAHATEDGVTVFAN
>NZ_CP013743.1|WP_058923392.1|4092762_4093347_-|suppressor-of-fused-domain-protein
MVDVLPLVEARLRTALGEPDARAAVTFLGTDRIEVLRFHEGDIVRYATLGMSAQPMSDPTAVLADPVKGPRAELVLSVRAGLADTDKALRPLAVLAASPQVEGVIVAPGASLEVGEPLWPGAPFSSVLVAEPGGLVEDLVLDEPLDPVRFLPLLPMTANEAAFKRVHGAQVLQERWLTHGTDLRDPSRKSVPLD
>NZ_CP013743.1|WP_058923393.1|4093855_4094986_+|magnesium-and-cobalt-transport-protein-CorA
MSMIRDLRAAVRPSRPSLRKSALHLDNGGYDTTRDPATPSAVVDCAVYRDGARVQTPQPMTPHEAMRSVRRDGGFVWIGLHEPTESEFSGIASEFGLHPLAVEDAVQAHQRPKLERYDDSLFTVFKTIHYVEHDELTANSEIVETGEVMCFTGRDFFITVRHGGQGSLRALRHRLQDDPELLAKGPSAVLHAIADHVVDGYLAVADAMQDDIDEVETEVFSPGRGGVARGVDSARIYQLKREVLEFKRAVSPLLRPMQLLSERPMRLIDPDIQKYFRDVADHLARVQEQVFSFDELLNSILQANLAQASVAQNEDMRKITAWAAIIAVPTMVTGVYGMNFDSMPELHWHYGYPTVLCVTVALCVGIHRSLKRNGWL
>NZ_CP013743.1|WP_058923394.1|4095009_4095522_+|hypothetical-protein
MTSELLDQALVEEATKKSGLIWVRGAGVPARALWHVWHEGAACVVGDGPGEQPLSGLADGGPAEVTVRSKDKGGRLVTWPATVVELASGSEAWQAAVAELKGKRLNAPDGEAMPQRWARECRVLRLEPAGTPAPLPDGSLAEAPLPTPATTRRPVPAGLPRLLFKKKRGR
>NZ_CP013743.1|WP_058923395.1|4095527_4096271_-|hypothetical-protein
MSVIPQDRIRRTTLLGAMCALVVTGTGFLTGCSEDPDAGTNGVGKLSAAQIQSRTRAAAESARTVRLAGTVVTNGRTYTLDMRLKADGGTGSVTSKGVAFGLLRIGGKLYLKAGAGFWNHADGGTGATSAGKLDGKYVKVPQGDPSYKRFSGFTDKDVLLEGLLTLHGSLATDGHHEQSGTRTIRITGDKGSGGTLDVSLEGKPYPLRLQRAGGAGTLTFSAWDKDFALSEPDRSETVDYGKQLPTS

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Crispr_ID: NZ_CP013743_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_4

4841989-4842080

Orphan

Consensus_repeat	Method
GATCGCCATGACGCCGGCCATCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013743_4

>merge|NZ_CP013743|4|4841989-4842080|CRISPRCasFinder
GATCGCCATGACGCCGGCCATCATGCCCTGGTACTTGCCCCGCTCCCGGGGCGGGATCAGGTCGCCGATGATCGCCATGACGCCGACCATCA

>NZ_CP013743|4|3|4841989-4842080|CRISPRCasFinder
GATCGCCATGACGCCGGCCATCA	TGCCCTGGTACTTGCCCCGCTCCCGGGGCGGGATCAGGTCGCCGAT
GATCGCCATGACGCCGACCATCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_058923989.1\|4837364_4838702_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP013743.1\|WP_079078027.1\|4847562_4847814_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058923990.1\|4838992_4839847_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|377216
NZ_CP013743.1\|WP_058923995.1\|4843221_4844001_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP013743.1\|WP_058923994.1\|4842617_4843217_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP013743.1\|WP_058923996.1\|4844361_4844961_+\|hydrolase	unknown	unknown	gnl\|CDD\|319765
NZ_CP013743.1\|WP_058923988.1\|4836642_4837347_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP013743.1\|WP_058924000.1\|4849159_4849711_-\|amino-acid-N-acetyltransferase	unknown	unknown	gnl\|CDD\|236132
NZ_CP013743.1\|WP_058923992.1\|4840338_4840758_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NZ_CP013743.1\|WP_058923984.1\|4831907_4833032_+\|DNA-integrity-scanning-protein-DisA	unknown	unknown	gnl\|CDD\|237395
NZ_CP013743.1\|WP_058923998.1\|4847990_4848614_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058923986.1\|4835353_4835893_+\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP013743.1\|WP_079078026.1\|4833055_4833886_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|164795
NZ_CP013743.1\|WP_058923991.1\|4839843_4840278_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319924
NZ_CP013743.1\|WP_058923985.1\|4834179_4835127_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NZ_CP013743.1\|WP_079078028.1\|4849720_4850125_-\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747
NZ_CP013743.1\|WP_058923999.1\|4848592_4848928_-\|Lsr2-family-protein	unknown	unknown	gnl\|CDD\|378714
NZ_CP013743.1\|WP_058924002.1\|4850272_4850452_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058923987.1\|4835880_4836534_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058923997.1\|4845034_4847560_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|214361

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_058923989.1\|4837364_4838702_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.23065e-31
NZ_CP013743.1\|WP_058923990.1\|4838992_4839847_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|377216	pfam04072, LCM, Leucine carboxyl methyltransferase. Family of leucine carboxyl methyltransferases EC:2.1.1.-. This family may need divides a the full alignment contains a significantly shorter mouse sequence.	5.28046e-49
NZ_CP013743.1\|WP_058923995.1\|4843221_4844001_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	7.912e-40
NZ_CP013743.1\|WP_058923994.1\|4842617_4843217_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.70976e-16
NZ_CP013743.1\|WP_058923996.1\|4844361_4844961_+\|hydrolase	gnl\|CDD\|319765	cd01624, HAD_VSP_like, vegetative storage proteins and related proteins, similar to soybean VSPalpha and VSPbeta proteins; belongs to the haloacid dehalogenase-like superfamily. Soybean [Glycine max (L.) Merr.] vegetative storage protein VSPalpha and VSPbeta levels were identified as storage proteins due to their abundance and pattern of expression in plant tissues, they accumulate to almost one-half the amount of soluble leaf protein when soybean plants are continually depodded. They possess acid phosphatase activity which appears to be low compared to several other plant acid phosphatases; it increases in the leaves of depodded soybean plants, but to no more than 0.1% of the total acid phosphatase activity in these leaves. This acid phosphatase activity has maximal activity at pH 5.0 - 5.5, and can liberate Pi from different substrates such as napthyl acid phosphate, carboxyphenyl phosphate, sugar-phosphates, glyceraldehyde 3-phosphate, dihydroxyacetone phosphate, phosphoenolpyruvate, ATP, ADP, PPi, and short chain polyphosphates; they cleave phosphoenolpyruvate, ATP, ADP, PPI, and polyphosphates most efficiently. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Soybean VSPalpha and VSPbeta lack this active site aspartate, other members of this family have this aspartate and may be more active. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.39693e-47
NZ_CP013743.1\|WP_058923988.1\|4836642_4837347_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	5.64314e-82
NZ_CP013743.1\|WP_058924000.1\|4849159_4849711_-\|amino-acid-N-acetyltransferase	gnl\|CDD\|236132	PRK07922, PRK07922, amino-acid N-acetyltransferase.	5.55879e-112
NZ_CP013743.1\|WP_058923992.1\|4840338_4840758_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	6.49488e-31
NZ_CP013743.1\|WP_058923984.1\|4831907_4833032_+\|DNA-integrity-scanning-protein-DisA	gnl\|CDD\|237395	PRK13482, PRK13482, DNA integrity scanning protein DisA; Provisional.	0
NZ_CP013743.1\|WP_058923986.1\|4835353_4835893_+\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	4.46436e-58
NZ_CP013743.1\|WP_079078026.1\|4833055_4833886_-\|hypothetical-protein	gnl\|CDD\|164795	PHA00370, III, attachment protein.	2.85397e-06
NZ_CP013743.1\|WP_058923991.1\|4839843_4840278_-\|glyoxalase	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	7.20832e-29
NZ_CP013743.1\|WP_058923985.1\|4834179_4835127_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	4.70257e-83
NZ_CP013743.1\|WP_079078028.1\|4849720_4850125_-\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	9.03509e-23
NZ_CP013743.1\|WP_058923999.1\|4848592_4848928_-\|Lsr2-family-protein	gnl\|CDD\|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	1.13015e-56
NZ_CP013743.1\|WP_058923997.1\|4845034_4847560_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|214361	CHL00095, clpC, Clp protease ATP binding subunit.	0

>NZ_CP013743.1|WP_058923992.1|4840338_4840758_-|helix-turn-helix-transcriptional-regulator
MDKMRQLRLAKDAMDRDWADSGLDLDAVAAHAGYSRFHFLRAFKEAYGETPRQYLTHRRIERAEEMLRSADLSVTEICHLVGFSSLGTFSARFKTRTGLPPSEYRTEHVGRGAALIPGCYAMLWAGGFPRRESNSEEAP
>NZ_CP013743.1|WP_058923991.1|4839843_4840278_-|glyoxalase
MILGLGISTVWTFDQQRTKAFFTEKLDFEVRSEVSMGEMKWVTVAAKDQPDLELTLMSLDGPGLDPESAAALKKLVSKGVLGAGAFRTDDCRGDYETFRARGVEFLQAPQERPYGIEAIFRDDNGNWYSLTERSEELDLSKDFG
>NZ_CP013743.1|WP_058923990.1|4838992_4839847_-|class-I-SAM-dependent-methyltransferase
MSAEEPGPEHTAVRVALWRALHLLADAPPHVVEDEVGLRIADPGEGWRERPDMDVDATRRTRASIVARARFVEDLVEELAEQGVRQYVVLGAGLDTFAQRRAADAGRLGLRVFEVDRPGPQAWKRQRLAALGLDVPAWLRFVPVDFEGDWWGRLAAAGLDPAAPAVVASAGVTMYLSEDDVSATFRLVAGLAPGSTFVTTFLRPVEDVEPEQQAQLRVAMEGARAAGTPFVSFYRPGPLIALAREAGFREARHVSAADLEKRYFTDRTDGLRPSRGEELLVATV
>NZ_CP013743.1|WP_058923989.1|4837364_4838702_+|HAMP-domain-containing-histidine-kinase
MRGTFRGEGTHEAGGIRTGLRWKLSAAIALVGALIAITLSLVVHNAARVSMLDNARDLADERLQIAQRNYELSGRLNFPNLQRDDPDLPRALREKVDEGRRATYVTERHNGVPDIWAAVPVKDGHVLSLHTGFTDRSTDILKDLDQALVIGSIAVVLGGSALGVLIGGQFSRRLRKAAAAANRVAKGETDVRVRAAIGGVVRDETDDLASAVDAMADALQQRLEAERRVTADIAHELRTPVTGLLTAAELLPPGRPTELVLDRAKAMRTLVEDVLEVARLDGASERAELQDLLLGEFVTRRVAAKDPGIEVRVVHESMVTTDPRRLERVLFNLLANAARHGKPPIQVTVEGRVIRVRDHGPGFPADLLADGPSRFRTGSSDRSGHGHGLGLTIAAGQARVLGARLTFRNVRPAGAPDHVPAEGAVAVLWLPEHAPTNTGSYPVLP
>NZ_CP013743.1|WP_058923988.1|4836642_4837347_+|response-regulator-transcription-factor
MADQTHVLFVEDDDVIREATQLALERDGFAVTAMPDGLSGLEAFRANRPDIALLDVMVPGLDGVSLCRRIRDESTVPVIMLSARADSIDVVLGLEAGADDYVTKPFDGAVLVARIRAVLRRFGHAGGGEKSDEGADGVSGGVLTFGELEIDTEGMEVRRAGQPVALTPTEMRLLLEFSSAPGTVLSRDKLLERVWDYGWGGDTRVVDVHVQRLRTKIGQDRIETVRGFGYKLKA
>NZ_CP013743.1|WP_058923987.1|4835880_4836534_+|hypothetical-protein
MRGLTPAGPEPGRGNLRAACTAVAVLAAVGLLASACATGGTGARDEGPAHADSVAGAAATPSSAPSASKAAKRVDAVKLVKDDPTVSAEVKRELKPCVADEYPVDVSYGDLTGGTVDDVVVNVLTCGDAVGVGSYVYREQGGRYQNVFQAEEPPVYAEIDRGDLVVTKQVYEKGDPVSSPSGEVVTTYSWAAGRFTERFHTRNDYSNAVGGGASPSS
>NZ_CP013743.1|WP_058923986.1|4835353_4835893_+|SigE-family-RNA-polymerase-sigma-factor
MAQGEVLEFEEYVRTRQDALLRSARRLVPDPTDAQDLLQTALVRTYGRWDGIADKRLADAYLRRVMINTRTEWWRARKLEEVPTEQLPDASVDDATEQHADRALLMDIMKVLAPKQRSVVVLRHWEQMSTEETAAALGMSAGTVKSTLHRALARLREELESRDLDARALEHEERERCAV
>NZ_CP013743.1|WP_058923985.1|4834179_4835127_+|A/G-specific-adenine-glycosylase
MTALTNIPAATAETPAAETPGTAPSPTALHSPVIDWFTENARDLPWRRPEAGPWGVMVSEFMLQQTPVNRVLPVYEQWLSRWPRPADLAEDAPGEAVRAWGRLGYPRRALRLHGAAVAIAERHGGDVPTDHAQLLALPGIGEYTAAAVASFAYGQRHPVLDTNVRRVLARAVTGVQYPPNATTAAERRLARALLPEDEHTASRWAAASMELGALVCTAKNESCHRCPIAAQCAWRLAGKPEHDGPPRRGQTYAGTDRQVRGKLLAVLREAHAPVPQSALDRVWHEPVQRARALDGLVADGLVEPLPGGLYRLPLT
>NZ_CP013743.1|WP_079078026.1|4833055_4833886_-|hypothetical-protein
MGSLRNPVGPLPSTIYWRRRVVLLSVLALLALLITWIVTSGGGGGKKDDGANGRTPAPTISAGPSSSGPAISQAPGGRDESSGGGSGSDAGGTGSAGSSGSGGDGSGSGSGAGGSSGAGGASGGGAGSGVGQGDTVPAGSTLPNCTAGAVKLSVRSLHNSYSPGDTVTLLVTAKNSSAGDCKVDLGPKSAVLTISKSTDSADDYWSSADCPKTAGSLLFRAPAKSGITYTVKWDRKPSAPQCATPPAGSAGAGTYLVELAAPGYGKTQTSFVLEND
>NZ_CP013743.1|WP_058923984.1|4831907_4833032_+|DNA-integrity-scanning-protein-DisA
MAANDRAAAPGKSGGSSGADGLMRASLSAVAPGTAMRDGLERVLRGNTGGLIVLGFDKTVEAMCTGGFVLDVEFTATRLRELCKLDGGIVLSSDLSKILRAGVQFVPDAMIPTEETGTRHRTADRVSKQVGFPVVSVSQSMRLIALYVDGQRRVLEDSAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVSAVAQRLEMVRRIATEIAEYVVELGTDGRLLALQLDELIAGVEPERELVVRDYVPEPTAKRSRTVDEALYELDALTHAELLELTTVAKALGYTGSPEALDSAVSPRGFRLLAKVPRLPGAIIDRLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRLAESSILERYV
>NZ_CP013743.1|WP_058923994.1|4842617_4843217_+|TetR/AcrR-family-transcriptional-regulator
MGGTMDGTKRQRRGNTRQRIQDVALELFAEQGYEKTSLREIAERLDVTKAALYYHFKTKEEILVSIFEDLSEPIEELIEWGKLQPHTLETKQEIIRRYNEALSQALPLFRFMQENQATVKELRIGEMFRNRMMGMRDILIDPDAALVDQVRCISAVFAMHAGMFALNDLPGTDKEKREAVLEVATALVVQAHQGTHTAG
>NZ_CP013743.1|WP_058923995.1|4843221_4844001_-|M23-family-metallopeptidase
MSPRLTSRSSRTSALRTRAAVLAAGFGMSAVLGAGVAVAADTTSVGTSASASASVSGVASAVEAQAAAQAKAAKTAAAAKAKAAAAKAKAAAAKKAAAKKAAAKAAAKKKAAAKAAAKKAASWVHPVRKYTLSAKFAQAGGMWQSTHSGQDFAVNSGTDVVAAHGGTVVKAGPNGAGDGPAYGNAIVIRHGNGTYSQYAHLSRIDVRVGQVVRTGQHIARSGNTGNSSGPHLHFEIRRTADYGSAIDPVAFLRAKGLSL
>NZ_CP013743.1|WP_058923996.1|4844361_4844961_+|hydrolase
MTSRRLWARRTAVITVSASALAALAAPANAATSTGSVDYATWQKDCQSVMDQALPYLKERIAAAGTGEKQAVVLDIDNTALETDFGFSWPQPANKPVLEVARYAQQHGVSLFFVTARPGIIYLPTEYNLEHDGYQVSGLYVRGLVDLFKDVAAYKTAQRVAIENKGYDIIANIGNSATDLSGGHADKTFKLPDYDGQLS
>NZ_CP013743.1|WP_058923997.1|4845034_4847560_-|ATP-dependent-Clp-protease-ATP-binding-subunit
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKALESLGISLEAVRQQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNRVRQQVIQLLSGYQGKETAAAGGPAEGTPSTSLVLDQFGRNLTQAARESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVKGEVPETLKDKHLYTLDLGALVAGSRYRGDFEERLKKVLKEIRTRGDIILFIDELHTLVGAGAAEGAIDAASILKPMLARGELQTIGATTLDEYRKHLEKDAALERRFQPIQVAEPSLPHTIEILKGLRDRYEAHHRVSITDEALVQAATLADRYISDRFLPDKAIDLIDEAGSRMRIRRMTAPPDLREFDEKIAGVRRDKESAIDSQDFEKAASLRDKEKQLLAAKAKREKEWKAGDMDVVAEVDGELIAEVLATATGIPVFKLTEEESSRLLRMEDELHKRVIGQKDAVKALSKAIRRTRAGLKDPKRPGGSFIFAGPSGVGKTELSKALAEFLFGDEDALISLDMSEFSEKHTVSRLFGSPPGYVGYEEGGQLTEKVRRKPFSVVLFDEVEKAHPDIFNSLLQILEDGRLTDSQGRVVDFKNTVIIMTTNLGTRDISKGFNLGFAASGDTKSNYERMKNKVSDELKQHFRPEFLNRVDDVVVFPQLTQEDILAIVDLMISKVDERLKDRDMGIELSQSAKELLSQKGYDPVLGARPLRRTIQREIEDTLSEKILFGELRPGHIVVVDTEGEGETKTFTFRGEEKSALPDVPPIEQAAGGAGPNLSKEA
>NZ_CP013743.1|WP_079078027.1|4847562_4847814_-|hypothetical-protein
MGGGDTQARWSHVRHRRTGEWGNCLACGNIVSHHRVGADVGVRGQEAIDGVGSWNERSPLAGLSCGRTGRGSSPHCLTALRSD
>NZ_CP013743.1|WP_058923998.1|4847990_4848614_+|hypothetical-protein
MVGSDPSVTPDLTVPLPRRPLEAGSRIREWYENELEWRTVPVRPGAPVRLSVGERFDVLDVPAAAGRAGLRHLGPYSPVALQGERMRLLVAPGSAEELPGLLDWLEWGGLVPDLRAIGEGGVMDAPSPPDRGDTLQGAAVWLRPPEPGRAVEASLPTLSATGGVGGAPDLVRLVDTVAAHCHRLRLRRACALPSAVDPASDQALAFS
>NZ_CP013743.1|WP_058923999.1|4848592_4848928_-|Lsr2-family-protein
MAQKVQVLLVDDLDGGEADETVTFALDGKTYEIDLTTANADKLRGLLEPYVKGGRRTGGRSAGGRGKTRPASGGSQDTAQIRAWAKENGYEVNDRGRVPASIREAYEKANA
>NZ_CP013743.1|WP_058924000.1|4849159_4849711_-|amino-acid-N-acetyltransferase
MSAESPEGLEGPEVSAKAITVRRARTGDVAAVRRLLDTYVRDRILLDKATVTLYEDIQEFWVAERDDNAEVVGCGALHVMWEDLAEVRTLAVKPGLKGAGVGHQLLEKLLHTARWLGVRRVFCLTFEVDFFGKHGFVEIGETPVDMDVYAELLRSYDEGVAEFLGLERVKPNTLGNSRMLLHL
>NZ_CP013743.1|WP_079078028.1|4849720_4850125_-|BlaI/MecI/CopY-family-transcriptional-regulator
MGELEDAVMTRVWKWNRPVTVREVLEDLQQERSIAYTTVMTVLDNLHQKGWVRREAEGRAYRYEAVSTRAAYAAALMNDAWSQSDNPAAALVAFFGMMSEEQRQALRDAVRMVQGPEEAAEQENPGSPPGDGGR
>NZ_CP013743.1|WP_058924002.1|4850272_4850452_-|hypothetical-protein
MDYVSALVPPVVMAVFFIGVIRVIVKTQGGANKAKEDAAVDAVLARTEGARQEIAKTDG

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Crispr_ID: NZ_CP013743_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_5

5470224-5470298

Orphan

Consensus_repeat	Method
CCCGCGCGGCGACGCCTCGGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013743_5

>merge|NZ_CP013743|5|5470224-5470298|CRISPRCasFinder
CCCGCGCGGCGACGCCTCGGCCGCTGGACCGGCCAGAGGCGCCGGGAGAGCCCCCGCGCGGCGACGCACTCGGCC

>NZ_CP013743|5|4|5470224-5470298|CRISPRCasFinder
CCCGCGCGGCGACGCCTCGGCCG	CTGGACCGGCCAGAGGCGCCGGGAGAGCC
CCCGCGCGGCGACGCACTCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_058924459.1\|5457795_5458458_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP013743.1\|WP_058924464.1\|5462626_5463037_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319899
NZ_CP013743.1\|WP_058924460.1\|5458469_5459279_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|180440
NZ_CP013743.1\|WP_058928315.1\|5479596_5480808_-\|L-2-hydroxyglutarate-oxidase	unknown	unknown	gnl\|CDD\|183292
NZ_CP013743.1\|WP_058924461.1\|5459528_5460311_+\|DUF4097-family-beta-strand-repeat-protein	unknown	unknown	gnl\|CDD\|372574
NZ_CP013743.1\|WP_058924473.1\|5476266_5477211_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381307
NZ_CP013743.1\|WP_058924466.1\|5463952_5466082_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_CP013743.1\|WP_058924474.1\|5477229_5478603_-\|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|379143
NZ_CP013743.1\|WP_058924462.1\|5460556_5462146_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|365906
NZ_CP013743.1\|WP_058924476.1\|5480896_5482321_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058924475.1\|5478666_5479539_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP013743.1\|WP_079078489.1\|5473721_5474765_+\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP013743.1\|WP_058924465.1\|5463175_5463739_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP013743.1\|WP_058924472.1\|5475148_5476168_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP013743.1\|WP_079078488.1\|5462230_5462572_-\|metallopeptidase-family-protein	unknown	unknown	gnl\|CDD\|240572
NZ_CP013743.1\|WP_058924469.1\|5471639_5472164_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP013743.1\|WP_058924467.1\|5466230_5467793_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|273331
NZ_CP013743.1\|WP_079078072.1\|5468034_5469954_-\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|376556
NZ_CP013743.1\|WP_058924468.1\|5470850_5471492_-\|GTP-cyclohydrolase-II	unknown	unknown	gnl\|CDD\|234745
NZ_CP013743.1\|WP_058924470.1\|5472231_5473365_+\|5-amino-6-(5-phosphoribosylamino)uracil-reductase	unknown	unknown	gnl\|CDD\|180169

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_058924459.1\|5457795_5458458_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.63981e-14
NZ_CP013743.1\|WP_058924464.1\|5462626_5463037_-\|VOC-family-protein	gnl\|CDD\|319899	cd06588, PhnB_like, Escherichia coli PhnB and similar proteins. The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.	1.33343e-53
NZ_CP013743.1\|WP_058924460.1\|5458469_5459279_-\|glucose-1-dehydrogenase	gnl\|CDD\|180440	PRK06172, PRK06172, SDR family oxidoreductase.	1.32756e-77
NZ_CP013743.1\|WP_058928315.1\|5479596_5480808_-\|L-2-hydroxyglutarate-oxidase	gnl\|CDD\|183292	PRK11728, PRK11728, L-2-hydroxyglutarate oxidase.	0
NZ_CP013743.1\|WP_058924461.1\|5459528_5460311_+\|DUF4097-family-beta-strand-repeat-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	1.18016e-07
NZ_CP013743.1\|WP_058924473.1\|5476266_5477211_+\|aldo/keto-reductase	gnl\|CDD\|381307	cd19081, AKR_AKR9C1, AKR9C family of aldo-keto reductase (AKR). Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).	1.95402e-165
NZ_CP013743.1\|WP_058924466.1\|5463952_5466082_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	2.26244e-115
NZ_CP013743.1\|WP_058924474.1\|5477229_5478603_-\|PrsW-family-intramembrane-metalloprotease	gnl\|CDD\|379143	pfam13367, PrsW-protease, Protease prsW family. This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Aflv_1074, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress.	5.17195e-51
NZ_CP013743.1\|WP_058924462.1\|5460556_5462146_-\|metallophosphoesterase	gnl\|CDD\|365906	pfam00149, Metallophos, Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.	4.08308e-14
NZ_CP013743.1\|WP_058924475.1\|5478666_5479539_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	2.54165e-93
NZ_CP013743.1\|WP_079078489.1\|5473721_5474765_+\|serine/threonine-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	4.89052e-40
NZ_CP013743.1\|WP_058924465.1\|5463175_5463739_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	1.00764e-06
NZ_CP013743.1\|WP_058924472.1\|5475148_5476168_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	2.47983e-36
NZ_CP013743.1\|WP_079078488.1\|5462230_5462572_-\|metallopeptidase-family-protein	gnl\|CDD\|240572	cd12952, MMP_ACEL2062, Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein. The subfamily includes an uncharacterized protein from Acidothermus cellulolyticus (ACEL2062) and its homologs from bacteria. Although its biological role remains unclear, ACEL2062 contains a minimal metalloprotease (MMP)-like domain consisting of 3-stranded mixed 2-beta sheets and a HExxHxxGxxD/S (x could be any amino acid) motif. It may belong to a superfamily of bacterial zinc metallo-peptidases, which is characterized by a conserved HExxHxxGxxD motif.	5.22551e-47
NZ_CP013743.1\|WP_058924469.1\|5471639_5472164_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	7.29118e-15
NZ_CP013743.1\|WP_058924467.1\|5466230_5467793_+\|amino-acid-permease	gnl\|CDD\|273331	TIGR00907, Choline_transport_protein, amino acid permease (GABA permease). [Transport and binding proteins, Amino acids, peptides and amines].	1.31803e-133
NZ_CP013743.1\|WP_079078072.1\|5468034_5469954_-\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|376556	pfam01510, Amidase_2, N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.	4.89793e-32
NZ_CP013743.1\|WP_058924468.1\|5470850_5471492_-\|GTP-cyclohydrolase-II	gnl\|CDD\|234745	PRK00393, ribA, GTP cyclohydrolase II RibA.	1.0611e-114
NZ_CP013743.1\|WP_058924470.1\|5472231_5473365_+\|5-amino-6-(5-phosphoribosylamino)uracil-reductase	gnl\|CDD\|180169	PRK05625, PRK05625, 5-amino-6-(5-phosphoribosylamino)uracil reductase; Validated.	1.81155e-43

>NZ_CP013743.1|WP_079078072.1|5468034_5469954_-|transglycosylase-SLT-domain-containing-protein
MTTHSDRRGHASPLRRTALLAAVAALAAAGATTVPVTAAAADASGRPAPSLERAFTAAADAYHVPRQVLLAVSYQESAWDTHPGQHSTDGGYGPMHLTDVTPAMLASGPAGAAGRGDLAQLAADPALHTLQAAAKLTGLSATKLRTDPAANIRGGAALLASYQKKVTGGTSADPGNWYGAVARYSQSTQRRGAAAFADRVFASLRKGAARTTSDGRRMSLAADSGIRPATGQLAGLHLKSAAATDVECPATLDCTFVPAAASNGQVSNRPANGIKIDTIVIHDTESSYDAAIKTAQAAGGAAAHYVMRSADGAVTQMVPTKDLAFHAGNYTANMHSIGIEHEGYAAHGATWYTEAQYEATAELVAYLAARYDIPLDRQHIIGHDNVAGPKSSLVSGMHWDPGPSWDWNHFMNLLGVHSGPHGVGPVGSAVTIAPRFANNLQTVQICPADDPTGATTACTETQQPSNFVYLRTEPSDTAPLFGDQAVHPGAAGTDRINDWGSTAVAGQQFVVADRDGDWTAIWYSGAKVWFYNPHGCNTAPAYGVQVISAAGASPVAVYGSAYPDAAEYPSGLSPSTQAPLSMYSVPAGQAYVATEPPAPTQDFFPSGGTVVTGAKSMYTIQYNHRVALVYAGDVTAAAQ
>NZ_CP013743.1|WP_058924467.1|5466230_5467793_+|amino-acid-permease
MTDDAIGSGQSGVSDEERLAQLGYTQVLARRMSAFSNYAVSFTIISVLSGCLTLYAFGMNTGGPAVITWGWVAVGLMTLFVGLSMAEICSAYPTSAGLYFWAHRLAPPRTAAAWAWFTGWFNVLGQVAVTAGIDFGAASFLGAYLNLQFGFEVTKGRTVLLFAAILLLHGLLNTFGVKIVALLNDISVWWHVLGVGVIVGALAFVPDHHQSASFVFGKFVNNTGWGSGVYVVLLGLLMAQYTFTGYDASAHMTEETHDASTAGPKGIVQSIWTSWIAGFVLLLGFTFAIQSYDKELGSATGAPPAQILLDALGATAGKLLLLVVIGAQLFCGMASVTANSRMIYAFSRDGALPFSRVWHTVSPRTRTPVAAVWLGAAGALVLGLPYLINVTAYAAVTSIAVIGLYIAYVIPTLLRVRKGDAFERGPWHLGRWSTPIGWVSVVWVGVITVLFMLPQVSPVTSETFNYAPVAVLVVLGFAAAWWAASARHWFLNPSHDRTRAREAARAGSSGGAGGAQKVDP
>NZ_CP013743.1|WP_058924466.1|5463952_5466082_+|DEAD/DEAH-box-helicase
MSISSTDHVVVSENEGTEDAVEVTFADLGLPEGVVRKLAQNGVTTPFPIQAATIPDALAGKDILGRGRTGSGKTLSFGLPTMTRLAGGRTEKHKPRAVILTPTRELAMQVADALQPYGDVLGLKMKVVCGGTSMGNQIYALERGVDILVATPGRLRDIINRGACSLENVEVAVLDEADQMSDLGFLPEVTELLDQIPAGGQRMLFSATMENEISTLVKRYLSNPVTHEVDSAQGNVTTMSHHILIVKPKDKAPVTAAIASRKGRTIIFVRTQLGADRIAEQLRDAGVKADALHGGMTQGARTRTLADFKDGYVNALVATDVAARGIHVDGIDLVLNVDPAGDHKDYLHRAGRTARAGRTGTVVSLSLPHQRRQIFRLMEDAGVDAGRHIINSGTAFEPEVAEITGARSMTEVQSESAANAAQQAEREVAQLTKELERAQRRATELREEADRLVARVARERGEDPEAAVAEAQAVVTEAAEIVAEASVPAQPAAQDVERTEPAPSYERRERRDNDRGGFRRDDRRDDRGGRSFERRDDRGGRGFERRDNDRGGFRRDDRRDDRPAGRSFERRDDRGGRGFERRDNDRGFERRDNDRGGFRRDDRRDDRPAGRSFERRDDRGGRSFERRDNDRGGFRRDDRPAAGRSFERRDERGGHRGSDRPFNRDRRDDRPGFRSGGHDRPYGRRDDHRGTGTGSFGRRDDKPRWKRNG
>NZ_CP013743.1|WP_058924465.1|5463175_5463739_+|hypothetical-protein
MRPMYVPVRLAATLMAVATAAGCMSVGEDAGGDGARPSHSAGRHGGEAAAGDTAASGGGWGLGAAADGKHPGKKGKGKDGGESASPSASPSAGASASAPARGGAGKTDQPGAPTPTRATPTPTHTDPQPPTPTEQPTSSAPEPPPSAEPSSSAHPDAGPQMVQREPAPTAGSPVQERRDGTARGAGV
>NZ_CP013743.1|WP_058924464.1|5462626_5463037_-|VOC-family-protein
MQIAAAQKITTFLMFEGDAEDAMNFYVSLFDDAEIVALTRYGADGPGKEGSVQHAAFSLAGTQFMCIDSPAHHDFTFTPAVSLFVQCDDEAELDRLHAALSEGGGELMPPGDYGFSRKFTWVNDRFGVSWQLNLPA
>NZ_CP013743.1|WP_079078488.1|5462230_5462572_-|metallopeptidase-family-protein
MTRESFEELVSQALDRIPPELTRVMDNVAVFVEDEPPADDPDLLGLYEGTPLTDRGEWYAGVLPDRISIYMGPTLRHCATREDVVHEVAVTVIHEIAHHFGIDDARLHELGWG
>NZ_CP013743.1|WP_058924462.1|5460556_5462146_-|metallophosphoesterase
MARVPAIAVTVVNRVRKSPHILTRRHRRTRRPAPALELVLQPRPWVRALGLVAVVLLGAWLGLLIVGNVRVPVGPMNTTMTLRPSLSGGTKINVSPLGALELNTHHAPVRLDVNVDQLDPTRAQALVDHPERLSGLQDEVVHDVEHGTLDLALRSCVAVVAGATALGLAVYRRPRRALAAGGTALALLMASGASAYATWNKDAVLEPKYSGLLSSAPSLVGNARNIVTEFDVYQKELARLVTNVTKLYDVTSTLPAYQPDPTTIRVLHVSDIHLNPASWKIIASLVTQYKVDVIVDTGDTMDHGTAAENGFLDPIASLGAPYVWVRGNHDSHVTQRYLERMKNVHVLDEGRAETVAGLRFAGLGDPQFTPDRSTVTGADQSEELAGAQLAAALNDQKAAGTPVDVAMIHEPSAARGVDGTVPLVLCGHLHHEGDEILEYGTRLRMEGSTGGSGLRALEHKYPAPVEASVLYFDRDTRRLQAWDSIKLGGLGETTAEVTRHLPKENRPGATPSPSGSATPGSPSPSPSGS
>NZ_CP013743.1|WP_058924461.1|5459528_5460311_+|DUF4097-family-beta-strand-repeat-protein
MQVFHTPAPIRAVVELGVGDVRITAGDRTDTTVDVLPADRADFRDLVTAAEAVVTCDGEELLVSVPRAGELPRGGGSVSVAIEVPAGSAVHGSALAADFHVTGRLGECRIVVDCGHVRLDRTGPLRLDSLLGNVTVGRVAGDVEAVAESGDVRIDSVEGRTRLTRTQGATHLGEVTGDVHVSVGSGDVRIGRAHAAVEVRVGRGDIGVGEAVRGPLALEAEHGTMEIGIADKAVEVRARTGAGDIVIRRAEFGADEEPSC
>NZ_CP013743.1|WP_058924460.1|5458469_5459279_-|glucose-1-dehydrogenase
MTPAQASVRPAPNTSGQAASLKGKVVLITGASSGIGQAAARLFAGRGARVVLVARRKKKLADLTDEIRATGGEVSYVVADVQNSAEIADAVAHTTTTYGRLDAAFNNAGTAVAPRPLHLIEDEAYEEVMNTNVRGVWNCMRHEIGALISSGGGSIVNTSSTAGLVATSAGAAYIASKHAVIGLTKAAAVEYVKDGIRVNVIAPGLTRSEMTDGWFARHPGARERSLTSAPQGRAADPEEVAEAAAWLCSDAASFVTGATLPVDGGATAW
>NZ_CP013743.1|WP_058924459.1|5457795_5458458_+|TetR/AcrR-family-transcriptional-regulator
MAQQERAIRTRAAILQAAAEVFAERGYAATTVADILKVAGVTKGALYFHFDSKKALAKGVLGVQTSLDVPAQNFKLQEMVDTAMVVAHRLTHDPVLRAGAKLSEDRDGRSQYGSAWPAWIELLTRYLVEAQQRNEVLAHVVPRETAEFVLTAFHGAQTYSHLEKNLTDIEYRVSVLFRHMLPSIAAPAVLANLDTAPDRGARVYAQMQSESEELPALRAG
>NZ_CP013743.1|WP_058924468.1|5470850_5471492_-|GTP-cyclohydrolase-II
MPDFPAATPRSRVRVPLRFDDGYSVDAELVTFHGLTDGREHLAVVLGDPAPGTVPLVRLHSECLTGDVFGSARCDCGPQLREAVERIAARGGVLLYLRQEGRGIGLYNKLDAYALQDQGLDTYEANAALGLPEDARDYTAAAQMLRSLGITEVDLLSNNPDKAGQLRDLGITVHDRVPTGVFTTTHNVRYLRAKVLQTQHTLPLAELTELSAG
>NZ_CP013743.1|WP_058924469.1|5471639_5472164_-|MarR-family-transcriptional-regulator
MTTRWLTGKEQRAWRAYIAATHLLEDAIDRQLQQDAGMPHLYYSILANLSEAPERRLRMTDLAEKSKITRSRLTYAVTRLEKDGLIRREDCQWDKRSSFAALTDEGMAVLERTAPGHVETVRAAVFDHLSEEQVERLEEISSAIVRALEGEETPRPTSDEVPWRRRSSPCSGSS
>NZ_CP013743.1|WP_058924470.1|5472231_5473365_+|5-amino-6-(5-phosphoribosylamino)uracil-reductase
MPYPHVLLSAAVSLDGYLDDTGPERLLLSSPADFDRVDEVRASVDAILVGAGTIRADNPRLLVNSPERRAARTAAGKPEYPLKVTVSGSGDLEPTAQFWHTGGEKVLYTTDEGARRAGAAGLAADVVPLGPGLDWRRLLEHLHDVRGVERLMVEGGGTVHTQLLLQGLADELQLVLAPVFVGDTKAPRLFGPGGYQGGRLRLVDSRRIEDVVLMRYEPTAPGTGPVPAAADHHWLRLACALAAQCPPSRTAFSVGAVVVAADGTELGRGHSREAGDPTVHAEEAALAKIDPADPRLAGATVYSSLEPCARRASRPKPCARLILEAGVRRVVTAWREPDTFVEEADGSGLLAAAGVDVVLLAEHEAAAKAPNGHLLGG
>NZ_CP013743.1|WP_079078489.1|5473721_5474765_+|serine/threonine-protein-phosphatase
MLPVLLLVAGAFYDWFTPAGFTAAPFFTAVPLVAAPLYSRLGTILAGVACVLVVLLIHTGLGILLHIDALTELVTVATVAALAVLINALVRRGDEQLASQRAIAEAAQRAVLPAPAERIGAFTIAARYEAAQRDAAIGGDLYAVQDSPYGVRLVVGDVRGKGMGAVAAVAVVIGAFREAAEQEATLEAVAGRLDRALAREGSRREGLDAFEGFTTAVLAELPHGDGVVRIVNRGHPPPLLLCPDGTVRPLPAREPALPLGMGELGAWPDRAEETRFPGGATLLLYTDGLCEARDRHGDFYDPAASLAGRAFPDPAGLIAVLAQEVHRHTGDGTTDDMAMLAVRRHAR
>NZ_CP013743.1|WP_058924472.1|5475148_5476168_+|M23-family-metallopeptidase
MASNPPAPAAPFVPSTEPFGFAPRTDEGQWEEWNPTAESIRPVRGKHRVSKQRGGGLARSSTVLGVGVIAAVGAGGMASANTGKPPVSISLPDLASVSHVFGDDEAPQGSATALSSVGVTTEDTAQGAKDAGEALRDRIMAQAEAQRVQVDSKAQAVTEATFSKQVDAAAAKAEQEAAAKAADAKEKAEAEAKKKEEQARLAELAKQFKLPVGSYTITGTFGQAGSMWSSGYHTGLDFAAPTGTLIKAIHSGTITEAGWAGSYGYRTILTLDDGTELWFCHQSSISVSVGQKVATGDVIGRVGATGNVTGPHLHLEVHPDGQATGIDPMTWLRGKGLNP
>NZ_CP013743.1|WP_058924473.1|5476266_5477211_+|aldo/keto-reductase
MTSLRKLGNSDLEVFPLSLGGNVFGWTADEATSFAVLDAYTAAGGNFVDTADSYSAWVEGNSGGESETIIGRWLAARGNRDDVVIATKVSQHPEFPGLSAANIKAAAEASLRRLGTDRIDLYYTHFDKPETPVEEIVGALDELVREGKVRAIAASNISAERLAESLEFSDREGLAKYVALQPHYNLVSRDTYEGPLQDLASRQGLATVPYYALASGFLTGKYRPGATVDGARAAGAGKHLQTERGRKVLAALDEVAEAHDAPVATVALAWLAAQPTVAAPIASARTPEQLPALLGVADLTLTDAELTRLTEASA
>NZ_CP013743.1|WP_058924474.1|5477229_5478603_-|PrsW-family-intramembrane-metalloprotease
MATFPPYPTYPPHSPHPDGPASGALGHAHWWQRKWVRYGALSTLLALSGLVILALVRQQTGTEGFLVGLGLAVLPVPLLIAAFRWLDRVAPGPWRNLLFAFAWGACAAALIAIVANSFATRWIATATADPSSADTLGATVIAPVVEESAKAAAVLLVFLFRRRDFTGIVDGVVIAGITATGFAFTENILYLGTAFGTDQLTGDRGIASVTAATFFVRVIMSPFAHPLFTVLTGIGFGLAATAAERQHVRRLLIPLCGLLLAMGMHATWNGSSTFGEFGFFAVYAVFMVPAFGLLTWLVIWTRQRELRTVREELPAYAAAGWLTPAEPFALGSMRARRLARDHAAHHFGKPAAQAVLQYEAYATSLAFLRHRGRRGRAGADFAVRERELLAELWNRREIAGPALNYAARATAPPVPVAAPPWPGHGGYGTHGAYGAYGQQTYPTYPPTPYPAYNPYRS
>NZ_CP013743.1|WP_058924475.1|5478666_5479539_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MSDSHHAPEAPRPAAHASAEPAGQPAHVPGVSVRHTRAKGEPRFPDGPRADPAGSHFERRIRSFQPRRSRVTAGQADALQRLWPKWGLDIDGQRVIDLAELFGNDNPVVLEIGFGMGEATAQMAAADAGTNILAVDVHTPGQGNLLNLADQNGLSNVRVGNGDAIILLREMLTPDALDGLRVYFPDPWPKKRHHKRRLIQPEFLDLVATRIRPGGIVHCATDWEPYAEQMLEVLTAHPEFENTRPDGGFSPRPDFRPLTRFEGQGLDKGHVVNDLLFRRVQHHNQPPTGA
>NZ_CP013743.1|WP_058928315.1|5479596_5480808_-|L-2-hydroxyglutarate-oxidase
MRAEVAYDCDVLVVGGGIVGLSTAYAITRAAPGTRVTVLEKEAGPARHQTGRNSGVIHSGIYYRPGSLKARYAVRGAAEMVKFCAEYGIAHAVTGKLIVATDKAELPRLHALVQRGRENGIPVRELGAPQIAEYEPEVRGLAAIHVGTTGVCDFVGVARQLAHGSGAEIRYGARVERIDRRAGLGVAVRTRTGDIVRARVLVNCAGLYCDEVARMTGDDPEMRIVPFRGEYYELARPELVRGLVYPVPDPAFPFLGVHLTRGIDGGVHIGPNAVPALAREGYGWGVVRPRELAGTLAWPGSWQLARRHWRYGAGELRRSVSRAAFTTAVRRLLPAVTADDLVPTAAGVRAQAVLRDGALVDDFMIKEGPRAVHVLNAPSPAATASLPIGREVARRALTMLGSV
>NZ_CP013743.1|WP_058924476.1|5480896_5482321_-|hypothetical-protein
MSREQRGPNEKLGAVLALAGISNAGLARRVNDLGAQRGLTLRYDKTSVARWVSKGMVPQGAAPHLIAAAIGQKLGRPVPLHEIGLADADPAPEVGLAFPRDVGQAVRSATELYRLDLAGRRAGSGGIWQSLAGSFAVSAYATPASRWLITPADSSVAREANSTEGSGAPLKVGHSDVQKLREAAEDARRWDSKYGGGDWRSSMVPECLRVEAAPLLLGSYSDEVGRALFGASAELTRLAGWMAFDTGQQEAAQRYYIQALRLARAAADVPLGGYVLASMSLQATYRGFGDEGVDLAQAALERNRGLATARTMSFFRLVEARAHARAGDAQAAGAALKAAEGWLERSREGDNDPSWLGFYSYDRFAADAAECYRDLKAPRQVRRFTEQALSKPTEEFVRSHGLRLVVSAVAELESGNLDAACEQGVRAVEVAGRISSARTTEYVKDLLHRLEPYGDEPRVVELRERARPLLMAPA

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Crispr_ID: NZ_CP013743_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_6

5535468-5535679

Orphan

Consensus_repeat	Method
CGCCTCGGAGCACCCCGGGCGTCCGGCGCCTGAGGAGGCCTCGTGTCGCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013743_6

>merge|NZ_CP013743|6|5535468-5535679|CRISPRCasFinder
CGCCTCGGAGCACCCCGGGCGTCCGGCGCCTGAGGAGGCCTCGTGTCGCCGGCTGCCTCCAGGCGCCTTAAGTGCCCTGCCGCCTCGGAGCACCTCGGGCGTCCGGCGCCTGAGGAGGCCTCGTGTCGCCGGTCGCCTCCAGGCGCCTCAAGTGCCCCGCCGCCTCGGAGCACCTCGGGCGTCCGGCGCCTGAGGAGGCCTCGTGTCGCCGG

>NZ_CP013743|6|5|5535468-5535679|CRISPRCasFinder
CGCCTCGGAGCACCCCGGGCGTCCGGCGCCTGAGGAGGCCTCGTGTCGCCGG	CTGCCTCCAGGCGCCTTAAGTGCCCTGCCGCCTCGGAGCACCTCGGGCGTCCGGCGCCTGAGGAGGCCTCGTGTCGCCGGTCGCCTCCAGGCGCCTCAAGTGCCCCGC
CGCCTCGGAGCACCTCGGGCGTCCGGCGCCTGAGGAGGCCTCGTGTCGCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_058924512.1\|5539132_5540917_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP013743.1\|WP_058924518.1\|5545479_5546502_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP013743.1\|WP_058924513.1\|5540906_5541638_-\|PH-domain-containing-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058924506.1\|5531389_5532205_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058924505.1\|5530749_5531289_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NZ_CP013743.1\|WP_058924510.1\|5535756_5536683_-\|mycothiol-synthase	unknown	unknown	gnl\|CDD\|132489
NZ_CP013743.1\|WP_058924519.1\|5546599_5547379_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP013743.1\|WP_058924504.1\|5528087_5530322_-\|RNA-degradosome-polyphosphate-kinase	unknown	unknown	gnl\|CDD\|235469
NZ_CP013743.1\|WP_058924511.1\|5536874_5538671_+\|bifunctional-metallophosphatase/5'-nucleotidase	unknown	unknown	gnl\|CDD\|277357
NZ_CP013743.1\|WP_058924514.1\|5541721_5543182_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP013743.1\|WP_058924502.1\|5526587_5527019_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239645
NZ_CP013743.1\|WP_058924509.1\|5534751_5535423_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058924503.1\|5527015_5528107_-\|CHAD-domain-containing-protein	unknown	unknown	gnl\|CDD\|214880
NZ_CP013743.1\|WP_058924516.1\|5543977_5544157_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058924515.1\|5543178_5543916_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP013743.1\|WP_058924507.1\|5532201_5533062_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213231
NZ_CP013743.1\|WP_058924501.1\|5525492_5526326_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058924508.1\|5533058_5534594_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058924517.1\|5544190_5545348_-\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|273938
NZ_CP013743.1\|WP_058924500.1\|5524822_5525170_+\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376835

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_058924512.1\|5539132_5540917_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.40652e-158
NZ_CP013743.1\|WP_058924518.1\|5545479_5546502_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.08182e-97
NZ_CP013743.1\|WP_058924505.1\|5530749_5531289_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	7.57843e-32
NZ_CP013743.1\|WP_058924510.1\|5535756_5536683_-\|mycothiol-synthase	gnl\|CDD\|132489	TIGR03448, mycothiol_MshD, mycothiol synthase. Members of this family are MshD, the acetyltransferase that catalyzes the final step of mycothiol biosynthesis in various members of the Actinomyctes, Mycothiol replaces glutathione in these species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	3.31258e-130
NZ_CP013743.1\|WP_058924519.1\|5546599_5547379_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	5.78835e-47
NZ_CP013743.1\|WP_058924504.1\|5528087_5530322_-\|RNA-degradosome-polyphosphate-kinase	gnl\|CDD\|235469	PRK05443, PRK05443, polyphosphate kinase; Provisional.	0
NZ_CP013743.1\|WP_058924511.1\|5536874_5538671_+\|bifunctional-metallophosphatase/5'-nucleotidase	gnl\|CDD\|277357	cd07412, MPP_YhcR_N, Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain. YhcR is a Bacillus subtilis sugar-nonspecific endonuclease. It cleaves endonucleolytically to yield nucleotide 3'-monophosphate products, similar to Staphylococcus aureus micrococcal nuclease. YhcR appears to be located in the cell wall, and is thought to be a substrate for a Bacillus subtilis sortase. YhcR is the major calcium-activated nuclease of B. subtilis. The N-terminal metallophosphatase domain belongs to a large superfamily of distantly related metallophosphatases (MPPs) that includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	5.51976e-134
NZ_CP013743.1\|WP_058924502.1\|5526587_5527019_-\|NUDIX-hydrolase	gnl\|CDD\|239645	cd03673, Ap6A_hydrolase, Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most preferred substrate, hydrolyzes to produce two ATP molecules, which is a novel hydrolysis mode for Ap6A. These results indicate that Ap6A hydrolase is a diadenosine polyphosphate hydrolase. It requires the presence of a divalent cation, such as Mn2+, Mg2+, Zn2+, and Co2+, for activity. Members of the Nudix superfamily are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site.	5.96195e-42
NZ_CP013743.1\|WP_058924517.1\|5544190_5545348_-\|trypsin-like-serine-protease	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	4.36249e-62
NZ_CP013743.1\|WP_058924503.1\|5527015_5528107_-\|CHAD-domain-containing-protein	gnl\|CDD\|214880	smart00880, CHAD, The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family. It has conserved histidines that may chelate metals.	7.25901e-07
NZ_CP013743.1\|WP_058924515.1\|5543178_5543916_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.27343e-92
NZ_CP013743.1\|WP_058924514.1\|5541721_5543182_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.89605e-51
NZ_CP013743.1\|WP_058924507.1\|5532201_5533062_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213231	cd03264, ABC_drug_resistance_like, ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.86228e-101
NZ_CP013743.1\|WP_058924500.1\|5524822_5525170_+\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|376835	pfam02583, Trns_repr_metal, Metal-sensitive transcriptional repressor. This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression.	1.16818e-33

>NZ_CP013743.1|WP_058924509.1|5534751_5535423_+|hypothetical-protein
MRGLVRELAGPVFRTLPWRAVAAGSLLGLVAAAVPRLSDGAGGPWVALNLLRAAVLAHALALAFLLDDRARHTTAAVPTRRPLRAALRLAPVVPVTALWWTAALLLVPSSVRPPTGAVTLEAAAACTLALAGAALAVRLSDEPRPGQSVAGALLVTAVLAVLLWPERWPLFVAPGDPKWAGAHERWAWLLAAALLVLGACLPEPTRGRLRHRQPRRPLTPSGA
>NZ_CP013743.1|WP_058924508.1|5533058_5534594_+|hypothetical-protein
MSAVLETTMPPVAVPERRPRWADVIQLARFEARQQLWFLPVFATLVLYVGYTVWRLLFPPDGMAAYPALQDVDRATQTGPLLLGIALFVCVNRAALRDRRRGTDRQVDAAPMEPWRRTLAHVLSVVPYAVLTALVVLGSFTWQALKPGAVGHGSPAELAVGPLCVLLFGALGVLAARLIPSSFAAPLLVVGLFAGALFLSAGTGDAPWSRWLSPVVSENSGDTLPSDLIGRPAAWHALYLTGLVLLAALGAVLAGGGRTRVLKAGLAGALALTLAGAVAQSGGDTPQLRAARVRASVSPEKVQTCVRHEGSTYCAFPEWTPRTATWAKVVDEVRSLAGGAAHTQPLLVRQRVEARYGLDSSSAFEPFAAPHRVSVGAAWGGNRVPEFSAAVASVLVAGDEKTAGDLCDGRMVTVMWLALAWQDDPMRSLRNVRLDDTVSGSAIVLSPTNPLRMTAAQTDVVRELLGKPKRAVEAAVKAHWTELTAPKLTTADAARLLGAAAPKGGEEKCES
>NZ_CP013743.1|WP_058924507.1|5532201_5533062_+|ABC-transporter-ATP-binding-protein
MTPTVSASGLCLRYGGTRALDDVSLRLTPGVTGLIGPNGAGKTTLLRVLATAVPADTGAFTVLGHDPATASGRQDVRRRLGYLPQTPGFHPDFTPFEFVDYVAILKELTDRGARHREVRRVLEMVDLGDVRGRRIKKLSGGMRQRVALAAALAGDPGFLVLDEPTVGLDPEQRMRFRELIAQAGEGRTVLLSTHQTEDVAMLCHRVLVMAGGGIRFDGTPAELAERAAGRVWSSAERDPGAKAGWRTGTGSFRNVGTPPSGADLLEPTLEDGYLLTLDDAGAEVAA
>NZ_CP013743.1|WP_058924506.1|5531389_5532205_+|hypothetical-protein
MTWHVEDDVLRAYALGELAAPMLWSADAHLMACGRCREVLARVGQPVDAGWERLDAELDAPRPGLVERLLLRAGVADHVARLLAATPVLRRSWLGAVVAVLATSVVAAQTAGSLTLFLALAPLLPLAGVALAYGPVLDPTYEMAVVSPMHGFRLLMIRTIAVLITGLGLDGLATLALPGYGLRVLTWLLPALALTSTGLALSARLGPVLAPSLVGGVWVALLLAADAHNTTATLAPFTALGQGVAAAVAALAGGLLFLSRDRFDRLQGSAV
>NZ_CP013743.1|WP_058924505.1|5530749_5531289_+|RNA-polymerase-sigma-factor
MSETRSDGELLRAAADGDRRAFEELYRRYAPWLTARLRGRCADGGVVDDVVQETFLAIWRGRARYHEDGDVAGWLWRIGSRRLIDALRGDGARGRLRQALARLRHRDEASAEERVLAGVEHGDLAGALVRLSPELRAVLQATVIDGLTTREAAVLLGIPPGTVKTRAMRARKQLREALT
>NZ_CP013743.1|WP_058924504.1|5528087_5530322_-|RNA-degradosome-polyphosphate-kinase
MSQPETAQAQVQHAQPSVGSIAAHRPHTVAAVVSDLEPDIDADLDAYEETPVDGVQLPQGRFLDRERSWLAFNERVLELAEDPNTPLLERANFLAIFASNLDEFFMVRVAGLKRRIATGVATRSASGLQPREVLEMIWARSRELMARHAACYHEDVAPALAEEGIHLVRWSELTEKEQARLFTLFRHQIFPVLTPLAVDPAHPFPYISGLSLNLAVVVRNPVTGHRHFARVKVPPLLSRFLESSPGRYVPIEDVIAAHLEELFPGMEVLEHHAFRLTRNEDLEVEEDDAENLLQALEKELMRRRFGPPVRLEVEESIDREVLDLLVRELKISEAEVYPLPGPLDLTGLFRIASLDRPELKYKKFIAGVHRDLAEVESASAPDIFAALRSRDVLLHHPYDSFSTSVQAFLEQAANDPDVLAIKQTLYRTSGDSPIVDALIDAAESGKQVLVLVEIKARFDEHANIKWARKLEEAGCHVVYGLVGLKTHCKLSLVVRQEGDTLRRYSHVGTGNYHPKTARLYEDLGLLTADPQVGADLSDLFNRLSGYSRRETYRRLLVAPKSLRDGLIARINKEVQHHRAGRPAFIRIKVNSMVDEALIDALYRASQAGVPVDVWVRGICAIRPGVTGLSDNIRVRSILGRFLEHSRVFAFGNGGEPEVWIGSADMMHRNLDRRIEALVRVTDPAHRAALNRLLETGMSDNTASWHLGPDGEWIRHATDADGQPLRNIQEMLIDARRRRRGTATP
>NZ_CP013743.1|WP_058924503.1|5527015_5528107_-|CHAD-domain-containing-protein
MAQQHLDPTDPTAGPAPTGDALAGYLRAQATEFLRALRQHRETGTAPGTAEGSVEATRALRRSVRRISASLHTYRPLLDADWSEGLRPELAWLSGTLSMEHAYAARLERLLLALQRLSGAAVFPAQTGVATVGRAPDTVQLQAAHAAAGPPSPTPDRGNLTVGAAKAGALLERQLTLARTRAHSTALQALGSSRFHAVADTIAVLASEVPLTATAPGADLRPLAIAAEERLTDAVAALPLVTAGHPYNAAALIHGLSPDPSPHPQDAPWHQVRLLLRLHRYAREALYGDKASLDVRLLTAGQALHRHRDASEAAAAAASAARTPRIAPATAYALGVLHADQRHEVEAARFAFQQCWQKQVVST
>NZ_CP013743.1|WP_058924502.1|5526587_5527019_-|NUDIX-hydrolase
MTAVPENYGSLVHAAGCVLWRRSPVDGDLEVCLVHRPKYDDWSHPKGKLKRGEDHLAGALREVAEETGYTAQPGAELSTVRYFAQNRPKQVRYWAAEAASGGFTPTDEVDRILWLSPAAARSRLTQHRDRGLVDELLTTLRHA
>NZ_CP013743.1|WP_058924501.1|5525492_5526326_-|hypothetical-protein
MTQQRRGWRGAVAAGVAVCLGCLCASGCSGGAAADDARSSDPVPLLREAGQTLEEAGTSKATTSMEMATGGTRVTIRGQGVYDYGRRLGRLKVTLPQDPAGTNEHRPIIELLAPGALFMKNRGAGVPADKWVRVDTAGLSDGNLVTGGATDPFTAAALLRGTRTAVYLGRTELAGTGVRHYRGTADLRLAAKGAPPGVRESLAAAAKGFASAEVPFDVYLDDQGRIRKIRHRFGFVGGADTGTVAVASTTLLYDFGAPADVRLPAPKDIYAGRIAEH
>NZ_CP013743.1|WP_058924500.1|5524822_5525170_+|metal-sensitive-transcriptional-regulator
MTTTESGATAPSENGTQSTQHATHGYHKQKDEHLKRLRRIEGQIRGLQRMVDEDVYCIDILTQVSASTKALQSFALQLLEEHLRHCVADAALRGGDEIDAKVDEATKAIARMLRT
>NZ_CP013743.1|WP_058924510.1|5535756_5536683_-|mycothiol-synthase
MTSDDIARTGRPRSIETHSALTGEQTEAVLALLAEAALTDGRQAVSEQGRLQLRGGAREGVSHLLLTVDGELVGYAQLEDTDPVEAPAAELVVHPAHRGHGHGRALGTALLAASGKRLRVWAHGGHAAARHLAQVLGLTLFRELRQMRRSLTGLNLPDPVLPPEVTVRAFVPGRDDAAWLAVNAAAFAHHPEQGSLTQRDLDDRMAEPWFDPAGFFLAFRGDDLVGFHWTKVHAEEGLGEVYVLGVRPGEQGGGLGKALTTIGLRHLAGQGLPNAMLYVDADNKTAVSVYERLGFITYETDLMYRTET
>NZ_CP013743.1|WP_058924511.1|5536874_5538671_+|bifunctional-metallophosphatase/5'-nucleotidase
MPATSQPYPQRRRAYRLFAAAAGLATVGALAAALPADAHENRGGHHPSRYQDVQLLSFNDLHGNLEPPSGSSGRVTELQPDGTTKTIDAGGVEYLATHLREARQGKAYSITAAGGDMVGASPLVSGLFHDEPTIEALNKLDLDVTSVGNHEFDEGSKELKRLQYGGCHPTDGCYTDEGFEGADFPYLAANVLDEKTNRPILKPYWVWKKKDVRIGFIGVTLEDTPGVVSADGVKGLKFKDEVETINKYAKVLRAQGVNSIVALIHEGGLPASGAYNYDCDSSGAGAGISGPIVDIAKNITPSVDALVTGHTHAAYVCTIPDPSGKPRMVTSAASFGRLYTDTTLTYDRLTGDIVRTAVKSANHVVTRTVAKAPDMTDLISRWNTLAAPVGNRPIGYISADVPNTGTESPMGDLIADAQLAYGRKLDPETDLALMNPGGVRAGLTYAAKGAEGDGVVTYAEGFTVQPFSNTVNLQNFTGAQLIQVLKEQVSGTNTAAPKILQPSANLSYTLDLTKAGADRVVTDSIRLNGAAIDPAATYRVATNSFLAGGGDGFTTLGQGTDDLVGTDDLAALAEYLTANSSASGPLAPPAANRITIVQ
>NZ_CP013743.1|WP_058924512.1|5539132_5540917_+|ABC-transporter-ATP-binding-protein
MREIRAAFGRFWPLTRGDRRWLVTIVACVIVSAIAETASILLFAELTDNALKAGSLSAFWGPAGAWLGVAALGALVGYLGNSLATWTAERFVLRLRAGVFRHVQDLPPHFFQRHRQGDLVERLTGDVEAIEQLVVSGVVGTVSAAFSAVFYACAALYLRWDLALATFVLTPLFLLAARRFSGRIKAASQDERVADGAITSVVEESLGNIVLTQAYNRRADEERRLDREARAWMRASVRGARLSEMYEQFVEVVETLCVLAVIGLGVWEISAGRMTLGQLLAFAAFIGYLYPPVRSLGQLGLTLTAATAGAERLNEILDARPAVTDPARPAAEWPVRGWVGFHQVSFRYPESRRASLRDVTFSAGPGELVIVTGASGAGKSTLSKLLTRFYDPAQGVITLDGVPLTDLSLRFLRENVALLPQETLILNGTIRENIACGRPGASDEEIRRAAREAAADNFITALPEGYDTPIAPGTAALSGGQLQRVAIARAMLRAAPVLVLDEPTAGLDAVAARQVVTPLRRLMAGRTTIMITHDLSLAPDADRILVVDRGRLVETGTHPELLARGGAYAALAQPLPDAVADRPQATDETMILRW
>NZ_CP013743.1|WP_058924513.1|5540906_5541638_-|PH-domain-containing-protein
MGGDTGAVERVYRRRRRPPLLQLGVAVLIGGNALFRAGGVGDPAADRHGPPHWMPLSVGVLFTATLVRIALEQLRAHTRVTASGITVQGRLRSRFWYWADVYDIRVEPAPRGSGSQGPRWLTYLYDVEGRRHLLWHLDDRQVGDPYAEVSELCLAAAPYRSLAWEPSPRVEELIRRGAARRKAWNRAGYSALAVFFAMFAVDFWEVVTGRPEHLFLLLVVVPLACFGILGAVLQRWSALRPTT
>NZ_CP013743.1|WP_058924514.1|5541721_5543182_-|HAMP-domain-containing-histidine-kinase
MKKVLRRFQTLPIRSRLAMLVAAAVAFAVAAVSVTCWFIVQGKLYEQVNADLQKQLGNRQFPLRDQADQAVNHCTTKVTQDSGNPPRTTYFQVVSETGRTCVLPFSAGTVKVTQTDKRLIKEGNDGDGVFHNSVDSNGNAVRVLALPGFAITDRDTGVSSKAALLIALPLKNTEKTLNDLALILLLVSGVGVLGAGAAGLAVARAGLRPVDKLTEAVEHVARTEDLGIRIPVEDDAEDEVARLSRSFNSMTSSLASSRELQQQLIADAGHELRTPLTSLRTNVELLTRSEETGRPLPEADRKALLASVKAQMTELASLIGDLQELSRSEGQRGERVQVVSLRDTAEAALRRARLRGPELTITADLESWYVRVEPSALERALVNILDNAVKFSPDGGTVDVRLSEGVLTVRDHGPGIPEDELPHVFDRFWRSPSARALPGSGLGLSIVARTVQQAGGEVTLERAHGGGTVATVRLPGAPTPPPDAAR
>NZ_CP013743.1|WP_058924515.1|5543178_5543916_-|response-regulator-transcription-factor
MSPADGDREPQRILIVDDEPAVREALQRSLAFEGYDTEVAVDGADALDKATAYRPDLVVLDIQMPRMDGLTAARRIRGAGDTTPILMLTARDTVGDRVTGLDAGADDYLVKPFELDELFARVRALLRRSSYAAAAGAATADEDEALTFADLRMDLATREVTRGGRPVELTRTEFTLLEMFMAHPRQVLTREQILKAVWGFDFEPSSNSLDVYVMYLRRKTEAGGEPRLVHTVRGVGYVLRQGGAE
>NZ_CP013743.1|WP_058924516.1|5543977_5544157_-|hypothetical-protein
MIQQVSHPGAGTGPAAFTLALEVAYALHAPAGRAPEVAPVRAAGRRATTARTRRRTARA
>NZ_CP013743.1|WP_058924517.1|5544190_5545348_-|trypsin-like-serine-protease
MTESFRRDGEYEQYENPYQGARQHSSPVNPEWPPPPAYRPAQAEPVSTAPGTPAWPGGPQPMAGGEGGGNGGGTAVLPTVPAEPAPGAAPAARKRARGPFALLAAVAIVAAAIGGGTAYAFQELTGTDTAASSSTTASVVPSSKKGDVASIAAAVSPSVVEVSATLSNGTSTGSGVIITSGGEIVTNNHVVSGAQSIKVTTSDGKSYTAKVVGTDSKKDLALIKLAGASGLKPATLGNSSGVKVGDTVVAIGSPEGLSGTVTSGIVSALDRDVTVSTDENQGQQQGGGDGNWPFQFGGRQFNGDTGSSTTTYKAIQTDASLNPGNSGGALIDAGGNIIGINSAMYSASSSSGSSSSDAGSIGLGFAIPINTVKADLATLRSGSTS
>NZ_CP013743.1|WP_058924518.1|5545479_5546502_-|LacI-family-transcriptional-regulator
MAKVTRDDVARLAGTSTAVVSYVINNGPRPVAPATRERVLAAIKELGYRPDRVAQAMASRRTDLIGLIIPDARQPFFGEMAHAVEQAASERGKMVLVGNTDYVAEREVHYLRAFLGMRVSGLILVSHALNDLAAAEIDAWDARVVLLHERPEAIDDVAVVTDDLGGAHLAVQHLLEHGYDYVACMGGTAETPAVGDPVSDHVEGWRRAMEEAGKPTEGRLFEAPYNRYDAYRIALEILAGPRRPPAVFCSTDDQAIGVLRAARELRIDVPGELAVAGFDDIKEAALTDPPLTTIASDRSAMARAAVDLVLDDGLRVAGARRERLKTFPSRLVVRRSCGCD
>NZ_CP013743.1|WP_058924519.1|5546599_5547379_-|response-regulator-transcription-factor
MSSLLLLTNALQPSTEVLPALGLLLHNVRVAPAEGPALVDTPGADVILIDGRRDLPQVRSLCQLLRSTGPGCPLILVVTEGGLAAVTADWGIDDVLLDTAGPAEVEARLRLAMGRQQIVNDDSPMEIRNGDLSVDEATYSAKLKGRVLDLTFKEFELLKYLAQHPGRVFTRAQLLQEVWGYDYFGGTRTVDVHVRRLRAKLGPEHESLIGTVRNVGYRFVTPEKADRVPDEAKAAADRAKAEDADTASARDGAEVPADA

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Crispr_ID: NZ_CP013743_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_7

6508012-6508105

orTypeII

Consensus_repeat	Method
CGCCCGGGCGGGGGTCGTTGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013743_7

>merge|NZ_CP013743|7|6508012-6508105|CRISPRCasFinder
CGCCCGGGCGGGGGTCGTTGCCGTAACCGGGGGACCGCCGGGGCGGGGGTCGTTGCCGTAGCCGGAGGGGGCGCCCGGGCGCGGGTCGTTGCCG

>NZ_CP013743|7|6|6508012-6508105|CRISPRCasFinder
CGCCCGGGCGGGGGTCGTTGCCG	TAACCGGGGGACCGCCGGGGCGGGGGTCGTTGCCGTAGCCGGAGGGGG
CGCCCGGGCGCGGGTCGTTGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_058925240.1\|6513889_6515218_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058928409.1\|6515273_6516317_-\|glutamate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270408
NZ_CP013743.1\|WP_058925230.1\|6497884_6498562_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058925232.1\|6499712_6502427_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225669
NZ_CP013743.1\|WP_058925227.1\|6495091_6495544_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239217
NZ_CP013743.1\|WP_058928407.1\|6494866_6495076_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058925241.1\|6516331_6517777_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP013743.1\|WP_058925234.1\|6505787_6506201_-\|globin	unknown	unknown	gnl\|CDD\|381280
NZ_CP013743.1\|WP_058925239.1\|6511400_6513893_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|319004
NZ_CP013743.1\|WP_058925235.1\|6506268_6507282_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|275041
NZ_CP013743.1\|WP_058925233.1\|6502428_6505674_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376899
NZ_CP013743.1\|WP_058925231.1\|6498562_6499540_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP013743.1\|WP_058925243.1\|6518955_6520221_-\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|133432
NZ_CP013743.1\|WP_058925229.1\|6497474_6497888_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NZ_CP013743.1\|WP_058925228.1\|6495807_6497472_+\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NZ_CP013743.1\|WP_058925244.1\|6520228_6521122_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP013743.1\|WP_058925242.1\|6517993_6518965_-\|ATPase	unknown	unknown	gnl\|CDD\|225518
NZ_CP013743.1\|WP_058925238.1\|6508669_6510016_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|375997
NZ_CP013743.1\|WP_063824482.1\|6510113_6511400_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|223704
NZ_CP013743.1\|WP_058925245.1\|6521124_6522066_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_058925244.1\|6520228_6521122_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.98366e-84
NZ_CP013743.1\|WP_058928409.1\|6515273_6516317_-\|glutamate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.30037e-87
NZ_CP013743.1\|WP_058925232.1\|6499712_6502427_-\|ABC-transporter-permease	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	0.000143484
NZ_CP013743.1\|WP_058925227.1\|6495091_6495544_-\|NUDIX-domain-containing-protein	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	6.44571e-10
NZ_CP013743.1\|WP_058925241.1\|6516331_6517777_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.000726078
NZ_CP013743.1\|WP_058925234.1\|6505787_6506201_-\|globin	gnl\|CDD\|381280	cd14771, TrHb2_Mt-trHbO-like_O, Truncated hemoglobins, group 2 (O); Mycobacterium tuberculosis hemoglobin O like. The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. TrHbs are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). This group includes a Mycobacterium tuberculosis TrHb2, Mt-trHbO, encoded by the Mycobacterium tuberculosis glbO gene, which is expressed throughout the Mycobacterium growth phase. It also includes a TrHb2 from the thermophilic Thermobifida fusca ( Tf-trHb) which has a high thermostability and at the optimal growth temperature for Thermobifida fusca (between 55 and 60 degrees C ), it is capable of efficient O2 binding and release. Tf-trHb shares a relatively slow rate of oxygen binding with Mt-trHbO.	6.31015e-68
NZ_CP013743.1\|WP_058925239.1\|6511400_6513893_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|319004	pfam16918, PknG_TPR, Protein kinase G tetratricopeptide repeat. This domain is found at the C-terminus of protein kinase G and contains a tetratricopeptide repeat (TPR).	1.01083e-93
NZ_CP013743.1\|WP_058925235.1\|6506268_6507282_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|275041	TIGR04188, conserved_hypothetical_protein, methyltransferase, ATP-grasp peptide maturase system. Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).	4.36848e-78
NZ_CP013743.1\|WP_058925229.1\|6497474_6497888_+\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	2.67307e-29
NZ_CP013743.1\|WP_058925233.1\|6502428_6505674_-\|ABC-transporter-permease	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	8.53277e-07
NZ_CP013743.1\|WP_058925231.1\|6498562_6499540_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	4.69857e-91
NZ_CP013743.1\|WP_058925243.1\|6518955_6520221_-\|6-phospho-beta-glucosidase	gnl\|CDD\|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_CP013743.1\|WP_063824482.1\|6510113_6511400_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	9.4925e-38
NZ_CP013743.1\|WP_058925228.1\|6495807_6497472_+\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NZ_CP013743.1\|WP_058925242.1\|6517993_6518965_-\|ATPase	gnl\|CDD\|225518	COG2971, COG2971, Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism].	3.65518e-25
NZ_CP013743.1\|WP_058925238.1\|6508669_6510016_-\|VWA-domain-containing-protein	gnl\|CDD\|375997	pfam18571, VWA_3_C, von Willebrand factor type A C-terminal domain. This is the C-terminal domain of von Willebrand factor type A pfam13768.	1.6084e-17
NZ_CP013743.1\|WP_058925245.1\|6521124_6522066_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.93014e-70

>NZ_CP013743.1|WP_058925235.1|6506268_6507282_+|methyltransferase-domain-containing-protein
MGTHTLDEELADLAVTARAALVREIERSGAWEGDPVWREAFEAVPRHLFVPYYYVGVRGGYERRWGESPDRAAREKWMRGAYADAPLATRLRDGDLVSSSSQPSLMARMLAELRVGDGDRVLEVGTGTGYNAALLAHRLGDDDLVTTVDLYPEITETARRHLAAAGHRPAVVTGDGARGVPERAPFDRIMATCTLSSVPLAWLAQCAPGARVLTPLATGLIALTVEDAGHAEGRFLPTPAYFVPLRGESRPEPEPARLGNVPAPARGDDHFRFLSALTRGTLDPQEAYVLWEREGRPRRERYGVTVDGGGEWAWLDDPEGPYAWPLPARRPFSPGGR
>NZ_CP013743.1|WP_058925234.1|6505787_6506201_-|globin
MEHVKEIRRGTLETQTFYEQVGGEETFRRLVHRFYEGVADDPVLRPMYPEEDLGPAEERLTLFLIQYWGGPTTYSDHRGHPRLRMRHAPFVVNREAHDAWLRHMRTAVDDLGLSEEHEQELWRYLTYAAASMINTPD
>NZ_CP013743.1|WP_058925233.1|6502428_6505674_-|ABC-transporter-permease
MTGFGALARFVVLRARAHRLLLAAALLTVLLTTAVLATLTAYAGAIGDAALRHSLRDPRTAADSALIVKSEVPADRRAAADTAVRQAARRTFDGLPVTVRTLVRSGPYALPRSLQPPAERSGDPDLTYVAALDATQVRIVEGRMPRQAAGVEAALPQNAARRLGLRPGARLTLTDRLGGPKVRVTLTGLYRPVAADAPYWRLDDLGGRGVTTVDFTTYGPLLAAPGVLSGGKVSAGQSSWLVAADFSTLTTDRIGELRAAARAGGAALRRQPALGGSTAVTTGLPDVLDRVERSLLVSRSTLLIVALQLGLLAGCALLLVARLLSAERSGETRVLRARGASRARIAAFAALEALFLAVPAVVCAPLLSGPLTRLMAGQGALARIGLHPDVPAAGRPGVWLVAAGVALGCALAVTLPALTDEGRRPGRARALPGSVRAGADLGLLAVAAVAYWQLGRQTSGAVSGDRSGTLGIDPLLVAAPALALLAGTVLTLRLLPLVARLAERRAAGGRGLTAALAGWQLSRRPMRGAGPVLLLVLAVALGMLAIGQGASWSRSQDDRADFAAGAPVRVLGAGDGGPGRTETYAAVPGVRRTAPAVRTELPLSGDRTATLLALDTAHAADTLLLRRDLAPEPARPLLASLGTRTPSTGAKVPAHTARLRLTATLSSAPRTSAAADVTVTLEDAYGTPYQIPAGDLRPDGRPHTLDIPVSGGPLRLTGVQLVLPVPVGKAERQRLTLGGLTATGTDGGVRRIDLPGTWRAASSSDSDASAPDGSTDPAEPRVGTSGTPTVAYGTGYLPDAIHWDAAALTLRMQVAQPTPREVPAVATDRFLASVGARTGQRVDVTVAGESVPVRLTRAVRELPTAGEAGGGALLMDLRSLNRVLQTRYGTGVTPTEWWLGTGPGDSARVAAALRALPDLDPAQVVVRQETAAQLRDDPFGAGPEAAFAAAAGVAAALAAVGFAVSAAGSLRERGAELAVLRALGAPRRRLARMIAVEQGVLVTLALVVGTALGTVLTRAVIPLIVLTGRATRPVPAVLVELPLPQVALLLAAVAAAPLAVTAALAVRRGDPVVSLREQGGE
>NZ_CP013743.1|WP_058925232.1|6499712_6502427_-|ABC-transporter-permease
MRPVQAPWVRTRLRSAPGAAVALALLVVLTACLAAALPRAVDRYEDAGLRRAVERAQPKSTTVAVWAQPPSPLLSQEQREAALRPGPLAARYERIRAVVRAPLVPDPGQSTYGVRTATPMEASDGWLPRPSGLPARISLAAQQGLAAHVSAVTGRLPRTDGPVTARTPEVEAAVTAATAKSLRIRIGSRVHVPGVGRASLAVRVTGIVTPRDPKGAYWSTQPLLRTPALAVVPSNDPNKDYYWLGALLLSPDAAPALLGTSAVPWSYWQYAPTAGSLHSYDTDRLRSVIASLEGGPGLRRIGALTGPTTTVSTDLDDVLGTYTALRSGVRPLVAVAAFGAGTVAAVVLLMAGGLAADRRRTELALLRARGASLRGLMGRLVAETAVVALPAGALGCGVALLALPDARASYAIAAAATVTAVACATPAVRAALAHRVVRVHGGRADVASVRPSRRRTVAELTLAAVALGAVETLRRQGAQDNQLTSLAPVLTGVVAALLLVRLHPLPLRALARPAARLRGTVAHLSLARAARTSASAVLPLLALLTALTTAAFGGSVLAGVREARDQAALLAVGADARVETSAPLPAGLPERVRGMPGVRGLAAVSIAYQAQPGDGTQSVPLAGVDPREYAELADRTGLGRFSRSDLTARASSGAVPALASPAVAERYGSRPFPVRLEDGSTVTVRVAVVRPRTPAVTGDDFLVVDRAALSRTAARPNALLLTGAHLDGPALRRAAGDTASVRLRATERARYVDSPLQSGAEDVYTASVAAGAGYAVLALLLSLLRASPERAALLARLRTMGLTRGQGRRLLVLESLPQAALAAAGGALTGWATIRLLSPAVDLTTIALAAHDTPTAPAALRTDPTSLLLPALAVVAVTVGAAGLQAWWTGRRGSVSELRAGDTR
>NZ_CP013743.1|WP_058925231.1|6498562_6499540_-|ATP-binding-cassette-domain-containing-protein
MTATNPTLADLTTRAQSTRTRPAYGHDALITCDRLVRIFTTDGIEVQALQGLDLLVREGELMALVGASGSGKSTLMNILAGLDTPTAGAARVAGQDLLTMTAKDRLAYRRSTVGFIWQQTSRNLLPYLTAAQNIALPMQLAGTGSRPSRTSRRAHAERALELLELLEIPDCRDRRPHQMSGGQQQRVAIAVALANDPAVLLADEPTGELDSHTAEHVFAAFRTANERLGTTIVIVTHDQAVAGEVRRTVAIRDGRTSTEVLRRSEVDETTGHETVVAREYAMLDRAGRLQLPAEYTEALGMRDRVALELEPDHIAVRPDDSEDGT
>NZ_CP013743.1|WP_058925230.1|6497884_6498562_+|hypothetical-protein
MTVLHLADEGEAADLAAFLSRLIHYDRSAAVRLQAAGTALAVFGRPASFEVLAIRAVRLAKPYENGLDVTLDVTVSAGELLETVDESGATAAVPGAVTGPPWAGVLPPRGGWRPESGLSAPDELRATVGAAVAEFRSRTQELTPERRTRAELDAIGRDIWSRTVGDTPLPVRAVHAAQSLGFLRPGAPVDLFSSGAWLRLRTPFGSVAVRRAGVGAAALGVSVRR
>NZ_CP013743.1|WP_058925229.1|6497474_6497888_+|acyl-CoA-thioesterase
MRHLYRCPLRWSDMDAYGHVNNAVFVRYLEEARIDFLFRPEKDFKQGSVVARHEIDYKRQLVHRHHPVDIELWVSQIRAASFTITYEVKDDDVVYVRASTVVVPFDFEAQRPRRLTAEEKEFLEEYRDDAEEEAVAA
>NZ_CP013743.1|WP_058925228.1|6495807_6497472_+|energy-dependent-translational-throttle-protein-EttA
MAEFIYTMRKARKAHGDKVILDDVTLNFLPGAKIGVVGPNGAGKSTVLKIMAGLEQPSNGDAFLSPGYSVGILLQEPPLNEEKTVLENVQEGVAEIKGKLDRFNEIAELMATDYSDALLDEMGKLQEELDHANAWDLDAQLEQAMDALGCPPGDWPVTTLSGGERRRVALCKLLLEAPDLLLLDEPTNHLDAESVNWLEQHLAKYAGTVVAITHDRYFLDNVAEWILELDRGRAYPYEGNYSTYLETKQTRLKVEGQKDAKRAKRLKEELEWVRSNAKGRQAKSKARLARYEEMAAEAEKMRKLDFEEIQIPPGPRLGSIVVEVNNLNKAFGDKVLIDDLSFTLPRNGIVGVIGPNGAGKTTLFKMIQGLETPDSGSIKVGETVKISYVDQSRENIDPKKTLWAVVSDELDYINVGQVEMPSRAYVSAFGFKGPDQQKPAGVLSGGERNRLNLALTLKQGGNLLLLDEPTNDLDVETLSSLENALLEFPGCAVVVSHDRWFLDRVATHILAYEGDSKWFWFEGNFESYEKNKIERLGADAARPHRATYKKLTRG
>NZ_CP013743.1|WP_058925227.1|6495091_6495544_-|NUDIX-domain-containing-protein
MKVRHTVRAVLLDDGHLVFLRRGWPGGSPYCTTVGGGVEPYDADLEAALRREVREEIGATIGAATEFLTLTEPGEKVTVVQHYFRAEVLDIDPTRRGGPELDDPDTGDFSPVRVALDASAVAALELQPPELADYLCEHAETWGGVGPALR
>NZ_CP013743.1|WP_058928407.1|6494866_6495076_+|hypothetical-protein
MVAAVLATWVTLIVLLLAPSLLPDRWQYYIYSPASVGLWMLTMLVAPFVVCAAAWRWIRTGTRRPKDAA
>NZ_CP013743.1|WP_058925238.1|6508669_6510016_-|VWA-domain-containing-protein
MANFSKSNVPQFSMDVYQNEYLPEGGREVNAIVTVTATGGGTVGGAVTAPQLYSPGQGPSAAVALMVDCSGSMDYPPTKMRNARDATAAAIDTLRDGVHFAVIGGTHVAKEVYPGGGRVAVADATTREQAKQALRKLSAGGGTAIGTWLRLADRLLSSADVTIRHGILLTDGRNEHESPEDLRAALDSCAGRFTCDARGVGTDWEVKEVTGIASALLGTADIVADPAGLAADFTRMMETAMGKEVGDVALRLWTPVGTTIKFVKQVAPTVEELTDRRSEAGPRAGDYPTGSWGDESRDYHVCVEVPPAAVGREMLAARVSLVVPRPDGTAENLGAQGLVRAVWTDDMTASTSINPQVAHYTGQAELARAIQQGLDLRKAGDFDGATAKLGRAVQLASVSGNADTAKLLAKVVDVVDAATGTVRLKAKVAEADEMTLETRSTKTVRVKK
>NZ_CP013743.1|WP_063824482.1|6510113_6511400_-|serine/threonine-protein-phosphatase
MMSQMPQLSACPSCEWPLESGDRFCGACGYDLSALPPRPDDHPTVALNSPVAAPEGTDRPTAPEPAGPPAPEAAGVPLPPQAQPTGSPVSPASGVRFDRPPEPEEYPLQAPDPRVADLSAPGGEPKLCVACRAGRVDGDGYCENCGHAQPRERDHMEQECGPLAAVSDRGLRHHRNEDAFGIGHTALPDGTPASVAIVCDGVSSATRPDDASLAAARAASESVLAALPRGTHPQQALHDAIVAASHAVNALADEPATAREHAPHQNAPACTIVGAVVTSGLLVVGWVGDSRAYWVPVDRSSPPARLTEDDSWAAQMVAAGLMNEAEAYADERAHAITGWLGADAYELDPHTASFKPDRPGVVVVCTDGLWNYAEAAQEMAEAVPADADRHPLHSARVLVGHALDGGGHDNVTVAVVPFPAVSQGAGSA
>NZ_CP013743.1|WP_058925239.1|6511400_6513893_-|tetratricopeptide-repeat-protein
MSQAQQTCQRPDCEGSYEDVGGGELYCDTCGLAPVVAPGSPSSGSGATGSAGDNDGSGSGGSRPTGRGSSRTSSQSSKSRRSVSGRLSRSLSGRASGRSVSVRSSGSSSGTSGRGRLGAGLVQVPDVPRPDPRAMVLENPEVPERKRFCSRSDCGAPVGRSREERAGRTEGFCTKCGHPYSFVPKLKAGDVVHGQYEVAGCLAHGGLGWVYLAVDKAVSDRWVVLKGLLDTGDQDAMAAAISERRFLAEIEHANIVRIYNFVEHLDQRTGSMDGYIVMEYVGGKSLKEIANDRRTPDGKRDPLPVEQACAYGIEALEALGHLHSRNLLYCDFKVDNAIQTEDQLKLIDMGAVRRMDDEESAIYGTVGYQAPEVAEVGPSVASDLYTVARTLAVLTFDFQGYTNVFVDSLPDPDNIEVFRAYESFYRLLVRATDPDPARRFASAQEMGEQLTGVLREVVSLQTGRARPALSTLFGPELRVTDPELFPKLHGEVSRLGARAVLPRKAPARLPGSGDPSPGIVKPVDSPAAALALPIPRVDPADPNAGFLAGLMTTAPAELLGALSAAPAQSVETRLRQIRAWLENGDSEAALTSLATLEDEEPDDWRVVWYRGVAALVTGDREGAALAFDAIYDAFPGEMAPKLALGLCAEMLGQLDNAAEYYRLVWSTDPSYVSAAFGLARVQLAAGDRRSAVGTLESVPESSIHYTAARVAAVRARLRGRTAVPGDVPFLEDLTAAAGQVEALDAYGLDPARREQLSAEVLGCALDWILSGGRGSAPEGRRTLLGSELDERGLRFGLERSYRTLARLARGGEERIDLVERANRYRPRTWV
>NZ_CP013743.1|WP_058925240.1|6513889_6515218_-|hypothetical-protein
MGVTDPAGPVMDRDEVDRALARLGAEHEAIETSLLALQDHAGRRLLEGAELTGVTKERWASAEASITLLWAYFDAYSDALRSAREIRARRRWSSREDLVELTELLRGESVTLAGSTTAVANAPTLQGGSGRLSEQFSLSALVDRMNDLYATSLDMVVAADAVWSALPARIDLLAAELQRTRKLAHSVGVRPGEHPAGDDLERITRTLTSLREQVVSDPLAYWVPAQGSSAPGGGRPDLTVYDRQARALEDVRREIDAVLTVRQDAEQRLIRLRDVLSRADRTLAEARTARGEVLAKIAATEVPVVSGPPTALQEQLATAAEYRRHAQWHRLSPLLESLEQKAEDELLRARESLTAVTAPLAVRAELRGRLDAYKAKVARHGLAEDPFLIERYDAARRMLWSAPCDLRVAEQAVLRYQRAAAELLGAPRVPEQGGPEDRRGES
>NZ_CP013743.1|WP_058928409.1|6515273_6516317_-|glutamate-ABC-transporter-substrate-binding-protein
MNARSLTRSLRAGLRGWGGVSAMAVVCALALAFVLLLPRTQPVGAAAADAGQGLAHGVQAKADEKCTDGRPPQDHSLSPSGTSASQENVDAIKTRGRLVVGVDTNSYRWGYLNPNNANGALEGFDIDLAHRIARDLLGDADKVAFKAIPTSRRIDAIDDGEVDMVVRTMTITCDRLGQVDFSAPYFKTGQQVLAPKNSTITGYNATLAGKKVCSAATSTALDNLKADKGHRIPASTDIGTVVPNQLDCLVKLQLGEVDAVVTDGALAASQAAQDPTVELKGGLFTDEYYGVAMKKGSEDLVRQVNRTLANYIKDGGWADSYKTWLHPTMDQDNKKSPSATPPEATYR
>NZ_CP013743.1|WP_058925241.1|6516331_6517777_-|hypothetical-protein
MTTPPKSSTAPPGSGVPTLPAVPPQPASPAPPGPAPAPEPAPARRTAFAEGADRLRAAATTEPGRLRVIGALLALLVVAFGAVAAWQMTDRASAADDVLNSSQPLSSDAAEIYASLADANTAAASGYLAGPQEKPSVRQRYQRDIDTAAAKLVTAAASSKAGSRSARTIAELNKLLPAYQGLVETARANNRQGYPVGGAYLRAANETMQHQMLPKAEALYQRENQRLNSDYADAKAFPWAAVCLGVAALAALGWSQRRNYLRTNRVLNHGLVTASAASVVVLLWLVVGHTVARAGLNDSYDHGVRSLNVLHDARIASLTARSDENLSLIRRGADTTLVDKKPKDTYAVGYDTQIAKLAGSLTKAGSLADDAAGRKPVKDADSFMRAWKDRHAVAQKQNDQGDYRQARDKVIGVGKDPTSVCFDNVDAALQTALGHENREFRQAASGGRDALDGLPYGAAVLAVLGAAGAVLGIGRRLSEYR
>NZ_CP013743.1|WP_058925242.1|6517993_6518965_-|ATPase
MGMTARVLAVDAGNSKTDVAVVAADGTVLATARGGGFRPPVTGVEAAVDAVAAAVERAFTACGVTSVEHVSACLANADFPVEEERLAAALHARGWGASVEVRNDTFAILRAGVTEPRGVAVVCGAGINCVGMRPDGRTARFPALGRISGDWGGGWGLAEEALWHAARAEDGRGEPTALARTLPAHFGLTSMLALIEALHLETVAPARRHELTPVLFATAADGDPVARAIVDRLADEVVTMATVALTRLGLLEEETPVLLGGGVLAARHPQLDDGIRDLLAVRAPKAVPRVVTASPVLGAALLGLDKAGATAEAHERVRAHFER
>NZ_CP013743.1|WP_058925243.1|6518955_6520221_-|6-phospho-beta-glucosidase
MKLTVVGGGSTYTPELIDGFARLRDTLPIEELVLVDPAAERLELVGGLARRIFARQGHAGRIVTTSDLDAGVEGADAVLLQLRVGGQAARQQDETWPLECGCVGQETTGAGGLAKALRTVPVVLDIAERVRRTNPDAWIIDFTNPVGIVTRALLQAGHKAVGLCNVAIGFQRKFANLLGVTPADIHLEHVGLNHLTWETGVRLGGPEGENALPKLLAEHGDAIAADLHLPRALLDRLGVVPSYYLRYYYAHDEVVEELRTKPSRAAEVAEMERQLLTMYGDPELAEKPALLAKRGGAYYSEAAVDLAAGLLGAGGSPYQVVNTLNRGTLPFLPDDAVIEVQAAVGPKGPTPLPVPAVDPLYAGLTANVTAYEDLALEAALRGGRDRVFRALLAHPLVGQYAYADALTDRLIAHNREHLAWA
>NZ_CP013743.1|WP_058925244.1|6520228_6521122_-|carbohydrate-ABC-transporter-permease
MTQVLERPVRLKAPVSPAERTARRRSLLQWIAVHSLGVAAALFFVLPFVFVFLTSLMSDTQALSRDLVPHTWEWGNYRKVFDTPGFLTWWRNTLVYAGLGTVLTVVSSIPVAYALAKFRFRGRNLSLMLVISMMMLPPQVIIIPMYLFWAKQLDLSGTLWPLIIPMAFGDAFSIFLLRQFLMTIPNEYIDAAKVDGCGDLRTLLKVVVPMAKPGIAAVGLFQFFYAWNDYFGPQIYASENPGAWTLSYGLESFKGAHHTDWNLTMAATVLVMAPVILVFFFAQKAFVEGVTLTGVKG
>NZ_CP013743.1|WP_058925245.1|6521124_6522066_-|sugar-ABC-transporter-permease
MSAITLASKRRRSALRTLAFMSPWLIGFAVFFAYPLISTVYFSFMHYDGFRAPTWSGTKNWTYVFEHYPFFWPALRNTLWLVLVMVTLRVVFGLGVGMLITKIKTGTGVFRTLFYLPYLAPPVAATMAFAFLLNPGTGPVNSILEKAGIPAPGWFNDPSWSKPALTLLALWGIGDLMVIFMAALLDVPQEQYEAAELDGASAWQRFRFVTLPNIAPIVMFAVVTGVIQTMQYYTQPLIAGKVASGVIQGAGTQFEPGYPDKSTLTLPQLVYNLGFQRFDYGSACVVALVLFALSMVFTAFLMRRRGGLNLAGD

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Crispr_ID: NZ_CP013743_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_8

6935562-6935861

Orphan

Consensus_repeat	Method
CACNGANCCGTCNCCGNN	CRT

5 spacers

The CRISPR arrays of NZ_CP013743_8

>merge|NZ_CP013743|8|6935562-6935861|CRT
CACCGACCCGTCGCCCGTCCGCGCCTTCACCCGGTACGCCGCCTTCGGCACCGCGACCGTGACCGACCCGTCGCCGCTGCGCGAGTCCACCAGGTCCGGCACGACGCCGAACTCCAGATGCACCGACCCGTCGCCGGACGCCGCCCGCACCGTGCGCGAGTCGACCTCGGCGCGCACCGACCCGTCACCGGTGCGCAGCTCCAGCGGACCGGTGGAGTCGGCGACCCGCACGGAGCCGTCACCGGTGTGGATGCTCAGCGCGTCCCGGAAACCCCGCGCACGCACGCTGCCGTCCCCGTC

>NZ_CP013743|8|1|6935562-6935861|CRT
CACCGACCCGTCGCCCGT	CCGCGCCTTCACCCGGTACGCCGCCTTCGGCACCGCGACCGT
GACCGACCCGTCGCCGCT	GCGCGAGTCCACCAGGTCCGGCACGACGCCGAACTCCAGATG
CACCGACCCGTCGCCGGA	CGCCGCCCGCACCGTGCGCGAGTCGACCTCGGCGCG
CACCGACCCGTCACCGGT	GCGCAGCTCCAGCGGACCGGTGGAGTCGGCGACCCG
CACGGAGCCGTCACCGGT	GTGGATGCTCAGCGCGTCCCGGAAACCCCGCGCACG
CACGCTGCCGTCCCCGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_058928433.1\|6940227_6941130_-\|2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|235821
NZ_CP013743.1\|WP_058925564.1\|6944692_6945337_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|377857
NZ_CP013743.1\|WP_058925550.1\|6926886_6929382_+\|phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|378594
NZ_CP013743.1\|WP_058925557.1\|6938280_6938607_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058925560.1\|6941224_6941449_+\|DUF2277-domain-containing-protein	unknown	unknown	gnl\|CDD\|378364
NZ_CP013743.1\|WP_058925547.1\|6923916_6924654_+\|Tellurium-resistance	unknown	unknown	gnl\|CDD\|226595
NZ_CP013743.1\|WP_058925562.1\|6942257_6942710_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP013743.1\|WP_058925549.1\|6925693_6926866_+\|HpcH/HpaI-aldolase/citrate-lyase-family-protein	unknown	unknown	gnl\|CDD\|379744
NZ_CP013743.1\|WP_058925565.1\|6945728_6946310_+\|TMEM165/GDT1-family-protein	unknown	unknown	gnl\|CDD\|225030
NZ_CP013743.1\|WP_058925559.1\|6939743_6940217_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP013743.1\|WP_058925553.1\|6932677_6933970_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200598
NZ_CP013743.1\|WP_079078517.1\|6930743_6932630_+\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223815
NZ_CP013743.1\|WP_058925554.1\|6934010_6935390_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NZ_CP013743.1\|WP_058925548.1\|6924676_6925483_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376767
NZ_CP013743.1\|WP_058925551.1\|6929381_6930197_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319822
NZ_CP013743.1\|WP_058925561.1\|6941470_6942082_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP013743.1\|WP_058925546.1\|6922652_6923801_+\|DUF475-domain-containing-protein	unknown	unknown	gnl\|CDD\|237583
NZ_CP013743.1\|WP_058925558.1\|6938733_6939648_+\|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270704
NZ_CP013743.1\|WP_058925552.1\|6930222_6930438_-\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|274226
NZ_CP013743.1\|WP_058925563.1\|6942978_6944607_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|277335

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_058928433.1\|6940227_6941130_-\|2-dehydropantoate-2-reductase	gnl\|CDD\|235821	PRK06522, PRK06522, 2-dehydropantoate 2-reductase; Reviewed.	9.07865e-51
NZ_CP013743.1\|WP_058925564.1\|6944692_6945337_-\|HNH-endonuclease	gnl\|CDD\|377857	pfam07510, DUF1524, Protein of unknown function (DUF1524). This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.	3.81954e-10
NZ_CP013743.1\|WP_058925550.1\|6926886_6929382_+\|phosphoribosyltransferase	gnl\|CDD\|378594	pfam11202, PRTase_1, Phosphoribosyl transferase (PRTase). This PRTase family is fused to a C-terminal RNA binding Pelota domain, pfam01248. These genes are found in the biosynthetic operon associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.	7.39725e-149
NZ_CP013743.1\|WP_058925561.1\|6941470_6942082_-\|hypothetical-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	5.81241e-13
NZ_CP013743.1\|WP_058925560.1\|6941224_6941449_+\|DUF2277-domain-containing-protein	gnl\|CDD\|378364	pfam10041, DUF2277, Uncharacterized conserved protein (DUF2277). Members of this family of hypothetical bacterial proteins have no known function.	4.89634e-25
NZ_CP013743.1\|WP_058925547.1\|6923916_6924654_+\|Tellurium-resistance	gnl\|CDD\|226595	COG4110, COG4110, Uncharacterized protein involved in stress response [General function prediction only].	2.37481e-50
NZ_CP013743.1\|WP_058925562.1\|6942257_6942710_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	4.3194e-14
NZ_CP013743.1\|WP_058925549.1\|6925693_6926866_+\|HpcH/HpaI-aldolase/citrate-lyase-family-protein	gnl\|CDD\|379744	pfam15617, C-C_Bond_Lyase, C-C_Bond_Lyase of the TIM-Barrel fold. This family of TIM-Barrel fold C-C bond lyase is related to citrate-lyase. These genes are found in the biosynthetic operon, with other enzymatic domains, associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.	4.86543e-170
NZ_CP013743.1\|WP_058925565.1\|6945728_6946310_+\|TMEM165/GDT1-family-protein	gnl\|CDD\|225030	COG2119, COG2119, Predicted membrane protein [Function unknown].	2.98991e-24
NZ_CP013743.1\|WP_058925559.1\|6939743_6940217_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	3.9575e-20
NZ_CP013743.1\|WP_058925553.1\|6932677_6933970_+\|hypothetical-protein	gnl\|CDD\|200598	cd10976, CE4_CDA_like_3, Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins. The family includes many uncharacterized bacterial hypothetical proteins that show high sequence similarity to insect chitin deacetylase-like proteins. Chitin deacetylases (CDAs, EC 3.5.1.41) are secreted metalloproteins belonging to a family of extracellular chitin-modifying enzymes that catalyze the N-deacetylation of chitin, a beta-1,4-linked N-acetylglucosamine polymer, to form chitosan, a polymer of beta-(1,4)-linked d-glucosamine residues.	7.7545e-127
NZ_CP013743.1\|WP_079078517.1\|6930743_6932630_+\|penicillin-binding-protein	gnl\|CDD\|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	5.2695e-112
NZ_CP013743.1\|WP_058925554.1\|6934010_6935390_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	3.02108e-07
NZ_CP013743.1\|WP_058925548.1\|6924676_6925483_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	1.20692e-69
NZ_CP013743.1\|WP_058925551.1\|6929381_6930197_+\|hypothetical-protein	gnl\|CDD\|319822	cd07520, HAD_like, uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.12622e-05
NZ_CP013743.1\|WP_058925546.1\|6922652_6923801_+\|DUF475-domain-containing-protein	gnl\|CDD\|237583	PRK14013, PRK14013, hypothetical protein; Provisional.	0
NZ_CP013743.1\|WP_058925558.1\|6938733_6939648_+\|aminoglycoside-phosphotransferase-family-protein	gnl\|CDD\|270704	cd05155, APH_ChoK_like_1, Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and Choline kinase. This subfamily is composed of uncharacterized bacterial proteins with similarity to APH and ChoK. Other APH/ChoK-like proteins include ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). These proteins catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates, such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides, and macrolides leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	6.19205e-87
NZ_CP013743.1\|WP_058925552.1\|6930222_6930438_-\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|274226	TIGR02605, CxxC_CxxC_SSSS, putative regulatory protein, FmdB family. This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions].	1.83075e-10
NZ_CP013743.1\|WP_058925563.1\|6942978_6944607_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|277335	cd07389, MPP_PhoD, Bacillus subtilis PhoD and related proteins, metallophosphatase domain. PhoD (also known as alkaline phosphatase D/APaseD in Bacillus subtilis) is a secreted phosphodiesterase encoded by phoD of the Pho regulon in Bacillus subtilis. PhoD homologs are found in prokaryotes, eukaryotes, and archaea. PhoD contains a twin arginine (RR) motif and is transported by the Tat (Twin-arginine translocation) translocation pathway machinery (TatAyCy). This family also includes the Fusarium oxysporum Fso1 protein. PhoD belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	8.03097e-32

>NZ_CP013743.1|WP_058925554.1|6934010_6935390_-|hypothetical-protein
MTATPSQPYSPSVPRAHRHRHAFADTLALLALPLVAALALPAAFAGGGTRRWFGGRAESQRAEAQAAKDAAAAAFYELDTAQRDLRISIETITAVDSTPAARRAVSDFEALGRRIDEASQRYISAVDAHDLDRDDLEASVAAQARTELTQAKDELANVKRELDRFSEGLGPLLGKAETQLARLAPAVERARQGLLAASNALDAVRGSGLKADDLAARLAALAPELTKLNQGAGQHGVPQTLERAERVAREAEAVRVEAERLPEKAAEIDHRLVSLRTRAEALTTRAGQVEPVLSELRRRFSAACWQDLQQVPEHAVENVRQAETKLKEAQAARDAQRWPDATALLSTVRALLNTTDESVSAARDRLLRLNAVQKDPQAEVERTRFAIRDAQRLAMSGRSTPDPRHARPLDDSVARLDRAIASLQGRHPDYWHFLTETEAVRRTAARVVAQIREERGTAS
>NZ_CP013743.1|WP_058925553.1|6932677_6933970_+|hypothetical-protein
MSRTVQGAKAKGRRRKERAPRRPARPEVLTLAAFLVVASLVAGALALTRQDHPQPAASSQRSAKARPKAEPTWDGKTKVLGDGSTSYTGPQSGQLKPVPLKPGEKPPQFVVFSWDGALEGSDHLFSHYRELAEQYDAHMTFFLTGIYLLPKEKKTLYEPPLHKPGAAAIDYPTDEHVRTTLEQLRLAYNEGNEIGTHFNGHFCDSKTSGKYWTTDEWKQEIDQFYSLVEKWKTNTGFKDIPALPFDFKKEVVGGRAPCLEGQKNLLKVIKKYGYRYDASSPGGFQIWPTKNNGIWDFPLQLLPYQGADYQGLSMDFNFLYNQSGGETDGNPADYPTWQQQTVASYMDGFNRVYYGSRAPLFIGNHFEDWNGGIYMKAVDQVIKNVCKKKGVKCVSFKELADWLDVQKPETLAALRALDPAQSPDWTTVVK
>NZ_CP013743.1|WP_079078517.1|6930743_6932630_+|penicillin-binding-protein
MGWQRWLPSWRQWLGGFLGAIGLTSLFLVIAYAATDIPKNLNSYATQQDNVFYWSDGTPMARTGWVRRQAMPLKDIPEDVRWAVLAAENESFYSDPGISLKGITRALYRTIGKGDTEGGSTITQQYVKNVYLTQNQTVSRKFTEAMIALKLDNRMSKDQILEGYLNTSWFGRGTYGIQRAAQAYYGTDVSHLNASQGAFLASLLKGAGLYDPTLSPANHKRAVERWSWILDRMVKIGKLSPAERATYKTFPEPLKTARVYDTGKQSDYLVELAQQYAKKSANISDKQFDLGGYQIYTTFDRKRETRLTDAVTKARKEAKKQDPKAAKTVHYGAASVATDGRILAVYGGPDHRTQGYNESNASTVPAGSAFVPFVYAAGLEHGIRKTRTGPTTTVTPETVYDGDDGAVVTTPEGPYWDRSGKRVLAHNDDGKSYGQISLGNALAQGVNAPFTQLGMDTGLDKVRQTAVAAGLLSSSLGAQVPALATGSSTPSAIRMASGYATFAADGMHTEPYSVRRITKNGSRVPLATPTAHRAIGAEVAKDVSAALTSSLLRTHPTVPAVRAGGMAGIASDDKAAWYTGNTDTLSTAVVVYRMDLTKSLEPLPLKGIAGRPTGSVPFAVWSGAMGFD
>NZ_CP013743.1|WP_058925552.1|6930222_6930438_-|zinc-ribbon-domain-containing-protein
MPRYDYRCRTCGDTFEVSRPMARSSDPAACPAGHDDTVKLLSTVAVGGTASAPASKGAGGGGGCCGGGCCG
>NZ_CP013743.1|WP_058925551.1|6929381_6930197_+|hypothetical-protein
MPVLVASDLDRTLIYSPAALALTMPDARAPRLLCVEVHESRPLSFMTETAAALLTDLGDAAVFVPTTTRTRKQYLRINLPGPAPKYAICANGGHLMVDGVSDLDWHARVTARLADECAPLDEVREHLLVSADPLWVRKHRVAEDLFAYLVVERELLPEEWVKDLAVWAENRGWTVSLQGRKIYAVPKPLTKSAAMREVARRTGAELTLAAGDSLLDADLLLAADRGWRPGHGELAEAAWTAPQIAALPERGVLAGERILREFLRATRGGAS
>NZ_CP013743.1|WP_058925550.1|6926886_6929382_+|phosphoribosyltransferase
MINAVNDGQWSGTWVAERLGVELMGDDELTGLLGLALRRNPKRAHLLVSNVLGKHVPQSPSVVYGYGFALGRRVRELLGAEEAGEAVVLGYAETATGLGHSVADGIGSAPYLHSTRRPVAGVAAAGGFEESHSHATSHLLLPEDPALLAGDGPLVLVDDEFSTGNTVLNTVRDLHGRYPRRRYVVVALVDMRSAADAGRLEEFAAEIGARVDLVAAASGTVRLPEGVLEKGQALVARYEAESAAGGASSGAGEWGLVAQFPAPLAPTHPHPTVNRVDLLWPRDLPDGGRHGFTPAHRARLDAALPAMAARLAEALPPGARRVHVLGFEELMYAPLRLARELEQVAQGVEVRYSTTTRSPVLAVDDPGYAIRSRITFPAHDDPADGPGERYAYNVAGAGFDAVVAVVDSAADTPALHAPDGLLAQLAAHTPHVLLAVVPSYVPERPSMLPEPLRGPAFSSYAPEEVGWLLQDLSEVTLEAPTEEREEAIQSGGAHYAESLPVEYQPSEQYQELFHAALESAATRIAQAVGAVTELVLAERSPRPVLVSLARAGTPVGVLMRRWAQFRHGLDLPHYAVSIVRGRGIDANALRWLAAHHDPADVVFVDGWTGKGAITRELADAIQEFEASDGITGFDPEIAVLADPGSCVRTYGTREDFLIPSACLNSTVSGLISRTVLRADLVGPHDFHGAKFYRELAGADVSVDFLDAVSACFPEVTEAVDAQTKELLSADRAPTWEGWAAVERISEEYGIHDVNLVKPGVGETTRVLLRRVPWKILARAGAGADLDHVRLLAEQRGVPVEEVGELPYTCVGLIHPRFTRGATGADGKAVNV
>NZ_CP013743.1|WP_058925549.1|6925693_6926866_+|HpcH/HpaI-aldolase/citrate-lyase-family-protein
MRHFGHIAPEVRGRLFHQEPCEFDTDSPARTLSAALGATLYSPATRPRLADDIVKQAGLGVVSMVLCLEDSIDDADVVAGEENLVRQFAELDARAAAGAGLPLLFIRVRTPEQIADLVRRLGATVRLLSGFVFPKFTEERGIPFLEALAGAEAASGRRLFGMPVLETPELMYRETRVDALEGIARSVEKYRDRVLALRLGVTDFCSSYGLRRAPDMTAYDVQIIASVIADVVNMLGRADGTGFTVTGPVWEYFRVPERMFKPLLRTSPFLEGQAVELRERLIEHAMDGLLREISLDQANGLLGKTCIHPTHVLPVHALSVVSHEEFSDAADILRPERGGGGVLRSSYTNKMNEVKPHRAWAERTMLRAEVFGVAREDVSFVDLLAAGIPG
>NZ_CP013743.1|WP_058925548.1|6924676_6925483_-|TetR-family-transcriptional-regulator
MTHAMLKGSNVPLETTTVRAVLRWTPGQGVPDVDASALLLGPDGRVRSDEDFVFYNQPRHPSGKIWWLGKKRLADGPTDTIQTDLAGVESDVSRILLVASAEDVPFGRVPGLRILLYDARTADGEPLISFDIKPETGGETALICGELYRRGDTWKFRALGEGYADGLKGLATDYGISVDESEPETAQPQPAATSPAQPLPPEQPTAVPSQPAYGYPQPAPATQPAYGYPQPAPATAGAQTGYGYPPQVTTLPNPDFRLPPQGPQFIGR
>NZ_CP013743.1|WP_058925547.1|6923916_6924654_+|Tellurium-resistance
MGFFDGLLGSRTADFDSGSAATNSIELTKRHHQVSLTKQGAATGHLRVNLSWRMRTSDIGGSQRESLLRHPFKALRPPEVMGHSQSMVNVDLDLGCLYELTDGAKGVVQPLGGYLGDVNAPPYVKLSGDDRFGSGSGEDMYINLDHRDALKRLLVFVYIYDQTPAFDRTHAIVTLYPSNGPRIEIHLDERHPQARSCAVVMIENVKGELVVRREVKFVYGFQAELDRLYGWGLQWGRGYKAKAER
>NZ_CP013743.1|WP_058925546.1|6922652_6923801_+|DUF475-domain-containing-protein
MLLKTFGWSFAVTALGLVAAVFYGGWEAFGIVAILSVLEISLSFDNAVVNAGILKKMNAFWQKIFLTVGVLIAVFGMRLVFPVVIVAVTAKLNPIDAVNLALTDKDQYQQLVTDAHPAIAAFGGMFLLMIFLDFIFEDRDIQWLRWIERPLAKLGKVDMLSVCIALIVLLITSFTFATHAHQHGGAHVDKAQTVLISGIAGLITYMIVGGLSGYFEDKLEEEEEREHEEEERAEREGKPKSAVVLAGQAAFFMFLYLEVLDASFSFDGVIGAFAITNDIVLMALGLGIGAMYVRSLTVYLVRQGTLDDYVYLEHGAHYAIGALAVILMVTIQYQINEVITGLVGVVLIAWSFWSSVRRNRALAAAEGKAEGSDDKTEVPSGV
>NZ_CP013743.1|WP_058925557.1|6938280_6938607_-|hypothetical-protein
MATTYDFPSDLLAGQEELHQVRAELSALLKRLPWSVEPLDGFSDNGGWRKVERPASPGWTPDEQAEVEKLRRREHELAVFVTTHRFWTEVTAGDRVDARTTLKHAHEH
>NZ_CP013743.1|WP_058925558.1|6938733_6939648_+|aminoglycoside-phosphotransferase-family-protein
MTHTEIEITAELVRELLADQHPDLAGLPVRFGAHGWDNQLWRLGDDLAVRLPWATGSADALLRKEHAWLPALAPRLPLPVPVPQRVGEPSERFPRPWLVTTWVPGTPADRAPVTRGAEAADALAAFLDALHRPAPDGAPSGRDRGGPLSGSAEGFAGMLATATGLGLLPEPDAVRAVWEDAVAAPGWQGPASWLHADLHPANVLTGDGTLCGVIDFGDLCAGDPACDLAAAWLLLPEGAVDRFHAGCRSAADPASRRRARGWAVLKALSCALIGEAGVRGRPGGKPAWGPPARAALRRLVETAP
>NZ_CP013743.1|WP_058925559.1|6939743_6940217_+|carboxymuconolactone-decarboxylase-family-protein
MEARLNLMASPVAAKALKQIVAASHALGESGLPFATREFVSLRASQINGCAGCVDMHTKELAHAGESAVRINLVAVWREATVFSEAERAALELTEEGTRIADAAGGVPDEVWENAAKHYDEEQLVALVAQIAIINAFNRGNVMTRQPAGDYQVGRYR
>NZ_CP013743.1|WP_058928433.1|6940227_6941130_-|2-dehydropantoate-2-reductase
MANDALTVAVLGPGGIGGLLAGLLARAGHRVICLAGEETVQVLREDGVRVRSGRFGDFTARVEADTVLREPVDACLVAVKHTALEAALDRVPPQALGDGLLVPFLNGVEHPAALRARYGPGLVAPAVIRVESTRLAPGVIEHGSPFAEIDLTGEGVDRERLGALALALEAAGPVTRVLDDETAALWAKMSFLAPFALLTTLHAVPLGDVRTRHRDELTALVEETAAVSRACGGPADPAQAMARYDAFPPQTKSSMQRDAEAGRPLELDAIGGALLRAADRHGVSVPVTARVVRELTRAHA
>NZ_CP013743.1|WP_058925560.1|6941224_6941449_+|DUF2277-domain-containing-protein
MCRSIKTLRPPALPDEATEEEIRAAALQFVRKVSGFRAPAAHNREVFDHAVDVIAQATAELLDGLEVRGQRASA
>NZ_CP013743.1|WP_058925561.1|6941470_6942082_-|hypothetical-protein
MLESVGSLTGTPWIYAMVALSVLLDVFLPVLPSGVLVITAATAAAAGSATGRVPHGVPDILALTLCAALASLLGDLVAYRLAWRGGERLDRAIARSRRLTAAQERLGGALARGGGALVILARFAPAGRSVVSLGAGAAHRRARDFLPWSALAGLTWAAYSVALGYYGGQWLGATWLGTGVSVLALFAAGSGAAYVMRRPVKAS
>NZ_CP013743.1|WP_058925562.1|6942257_6942710_-|DoxX-family-protein
MSARLDAAQPYALGLFRMVVGLLFACHGAASLFGVLGGAFGTGATVRAGAWPSWYAAVIELVGGILVLLGLATRAAAFIASGSMAYAYFKVHQPHALWPIENGGEPAAFFCWAFLLLVFTGSGAFGLDRLLARRSTAQHERAAEQTPVTA
>NZ_CP013743.1|WP_058925563.1|6942978_6944607_-|alkaline-phosphatase-family-protein
MAELRLGPLLRYADGSSATVWVETSRPCTAEVRCADGSGGEAPTFQIAGHHYALVPVTGLTAGTTTSYDVHLDGALVWPPPDSRFPPSVIRAPREDDEVKVGFGSCRWAAPPADEPDPVGPDALDTLALRMAADPEGERPDVLLLLGDQVYADETSPATQRWLAARRDLGDPPGSQVADYEEYTRLYYESWLDPEVRWLLSTVPTCMIFDDHDVIDDWNTSAAWVEDMRATPWWRERLLSGLMSYWVHQHLGNLSPAELATDPLYAAVRELPDGTDELRAFASRADVDPASVRWSYRRDFGRVRLVMVDSRAARVLDEEHRAMLDPGEERWLREQVLDPGAYDHLLIGTSLPWLLPHLVHDAEAWSAALCRGDRGARWARFGEKLRRGADLEHWAAFPASFTGLAELIAQAGSGAGAPSTVLVLSGDVHHAYVAEASWPAGGGPDARVLQLTCSPVHNAVPRAIRVAFRFGWSTAARVLGRRFLRHGRCAPVPVKWRKTGGPWFGNQLMTLTMEGRSARLRLEQAREEGVLATVAESRLSPS
>NZ_CP013743.1|WP_058925564.1|6944692_6945337_-|HNH-endonuclease
MPKFYARRRLSILAALTGLIASVGLLNGPSASAALPTPVSASTARSYLASLTVATENRTGYSRDLFPTWITISGTCNTREYILKRDGTNVVTDSACAATSGSWYSPYDGATWTAASDLDIDHLVPLAEAWDSGASKWTTAQRQAFANDITRPQLLAVTDNVNQSKGDQDPATWVPSRSAYVCTYVRAWVQVKYYYDLSVDSAEKSALTSYLSGC
>NZ_CP013743.1|WP_058925565.1|6945728_6946310_+|TMEM165/GDT1-family-protein
MISITVLALVFGVVFLAELPDKTALAGLVLGARYRASYVFAGVAAAFLLHVVLAVAAGSVLTLLPQRLVHAVTGLLFLGGAAMLLFGKGDGEEEIRRPEDQSFWKVAGTGFMLILVAEFGDLTQIMTANLAARYDDPLSVGLGAVLALWAVAGLGIVGGKALMRRVPLKLITKIAALLMAGLGVWGLWEAVAG

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Crispr_ID: NZ_CP013743_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_9

7309293-7309355

Orphan

Consensus_repeat	Method
GGCCAGATGGGCGGCCCCATGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013743_9

>merge|NZ_CP013743|9|7309293-7309355|CRISPRCasFinder
GGCCAGATGGGCGGCCCCATGGGCCAGCCCCCCATGCAGCAGCAGATGGGTGGCCCGATGGGC

>NZ_CP013743|9|7|7309293-7309355|CRISPRCasFinder
GGCCAGATGGGCGGCCCCATGGGC	CAGCCCCCCATGCAG
CAGCAGATGGGTGGCCCGATGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_058925854.1\|7317402_7318989_+\|Na+/H+-antiporter	unknown	unknown	gnl\|CDD\|129911
NZ_CP013743.1\|WP_058925847.1\|7308444_7308729_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|376765
NZ_CP013743.1\|WP_058925857.1\|7321008_7321578_+\|dienelactone-hydrolase	unknown	unknown	gnl\|CDD\|223489
NZ_CP013743.1\|WP_058925856.1\|7319797_7320901_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|366370
NZ_CP013743.1\|WP_058925855.1\|7319037_7319778_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP013743.1\|WP_058925858.1\|7321587_7321938_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_107416171.1\|7306147_7306876_+\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|376831
NZ_CP013743.1\|WP_058925850.1\|7313905_7315159_+\|TraR/DksA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224648
NZ_CP013743.1\|WP_063824490.1\|7315220_7315796_+\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|237810
NZ_CP013743.1\|WP_058925840.1\|7299920_7301348_+\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	unknown	unknown	gnl\|CDD\|179297
NZ_CP013743.1\|WP_058925852.1\|7315902_7316847_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP013743.1\|WP_058925845.1\|7306881_7307601_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|143483
NZ_CP013743.1\|WP_058925843.1\|7303861_7304662_+\|FtsQ-type-POTRA-domain-containing-protein	unknown	unknown	gnl\|CDD\|135428
NZ_CP013743.1\|WP_058925846.1\|7307730_7308372_+\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|377370
NZ_CP013743.1\|WP_058925841.1\|7301369_7302731_+\|putative-lipid-II-flippase-FtsW	unknown	unknown	gnl\|CDD\|274232
NZ_CP013743.1\|WP_058925849.1\|7310172_7313310_-\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235681
NZ_CP013743.1\|WP_058925839.1\|7298853_7299924_+\|phospho-N-acetylmuramoyl-pentapeptide--transferase	unknown	unknown	gnl\|CDD\|234638
NZ_CP013743.1\|WP_058925842.1\|7302737_7303835_+\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	unknown	unknown	gnl\|CDD\|234825
NZ_CP013743.1\|WP_058925853.1\|7316843_7317317_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225064
NZ_CP013743.1\|WP_058925844.1\|7304940_7306137_+\|cell-division-protein-FtsZ	unknown	unknown	gnl\|CDD\|236468

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_058925854.1\|7317402_7318989_+\|Na+/H+-antiporter	gnl\|CDD\|129911	TIGR00831, Putative_Na+/H+_exchanger_Rv2287/MT2345/Mb2309., Na+/H+ antiporter, bacterial form. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds].	3.77482e-85
NZ_CP013743.1\|WP_058925847.1\|7308444_7308729_+\|YggT-family-protein	gnl\|CDD\|376765	pfam02325, YGGT, YGGT family. This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown.	0.000436233
NZ_CP013743.1\|WP_058925857.1\|7321008_7321578_+\|dienelactone-hydrolase	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	6.81853e-19
NZ_CP013743.1\|WP_058925856.1\|7319797_7320901_-\|mechanosensitive-ion-channel	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	7.13687e-27
NZ_CP013743.1\|WP_058925855.1\|7319037_7319778_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.0555e-54
NZ_CP013743.1\|WP_107416171.1\|7306147_7306876_+\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|376831	pfam02578, Cu-oxidase_4, Multi-copper polyphenol oxidoreductase laccase. Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.	1.98191e-85
NZ_CP013743.1\|WP_058925850.1\|7313905_7315159_+\|TraR/DksA-family-transcriptional-regulator	gnl\|CDD\|224648	COG1734, DksA, DnaK suppressor protein [Signal transduction mechanisms].	3.9307e-22
NZ_CP013743.1\|WP_063824490.1\|7315220_7315796_+\|signal-peptidase-II	gnl\|CDD\|237810	PRK14764, PRK14764, lipoprotein signal peptidase; Provisional.	5.7044e-90
NZ_CP013743.1\|WP_058925840.1\|7299920_7301348_+\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	gnl\|CDD\|179297	PRK01438, murD, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional.	0
NZ_CP013743.1\|WP_058925852.1\|7315902_7316847_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.67961e-101
NZ_CP013743.1\|WP_058925845.1\|7306881_7307601_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|143483	cd00635, PLPDE_III_YBL036c_like, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins. This family contains mostly uncharacterized proteins, widely distributed among eukaryotes, bacteria and archaea, that bear similarity to the yeast hypothetical protein YBL036c, which is homologous to a Pseudomonas aeruginosa gene that is co-transcribed with a known proline biosynthetic gene. YBL036c is a single domain monomeric protein with a typical TIM barrel fold. It binds the PLP cofactor and has been shown to exhibit amino acid racemase activity. The YBL036c structure is similar to the N-terminal domain of the fold type III PLP-dependent enzymes, bacterial alanine racemase and eukaryotic ornithine decarboxylase, which are two-domain dimeric proteins. The lack of a second domain in YBL036c may explain limited D- to L-alanine racemase or non-specific racemase activity.	7.25305e-77
NZ_CP013743.1\|WP_058925843.1\|7303861_7304662_+\|FtsQ-type-POTRA-domain-containing-protein	gnl\|CDD\|135428	PRK05529, PRK05529, cell division protein FtsQ; Provisional.	2.42544e-23
NZ_CP013743.1\|WP_058925846.1\|7307730_7308372_+\|cell-division-protein-SepF	gnl\|CDD\|377370	pfam04472, SepF, Cell division protein SepF. SepF accumulates at the cell division site in an FtsZ-dependent manner and is required for proper septum formation. Mutants are viable but the formation of the septum is much slower and occurs with a very abnormal morphology. This family also includes archaeal related proteins of unknown function.	1.06835e-30
NZ_CP013743.1\|WP_058925841.1\|7301369_7302731_+\|putative-lipid-II-flippase-FtsW	gnl\|CDD\|274232	TIGR02614, Putative_lipid_II_flippase_FtsW, cell division protein FtsW. This family consists of FtsW, an integral membrane protein with ten transmembrane segments. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	1.25549e-131
NZ_CP013743.1\|WP_058925849.1\|7310172_7313310_-\|isoleucine--tRNA-ligase	gnl\|CDD\|235681	PRK06039, ileS, isoleucyl-tRNA synthetase; Reviewed.	0
NZ_CP013743.1\|WP_058925839.1\|7298853_7299924_+\|phospho-N-acetylmuramoyl-pentapeptide--transferase	gnl\|CDD\|234638	PRK00108, mraY, phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional.	2.04083e-160
NZ_CP013743.1\|WP_058925842.1\|7302737_7303835_+\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	gnl\|CDD\|234825	PRK00726, murG, undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional.	3.46025e-139
NZ_CP013743.1\|WP_058925853.1\|7316843_7317317_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225064	COG2153, ElaA, Predicted acyltransferase [General function prediction only].	5.21544e-20
NZ_CP013743.1\|WP_058925844.1\|7304940_7306137_+\|cell-division-protein-FtsZ	gnl\|CDD\|236468	PRK09330, PRK09330, cell division protein FtsZ; Validated.	0

>NZ_CP013743.1|WP_058925847.1|7308444_7308729_+|YggT-family-protein
MSVVLQVIYIALMCFLIVLIFRLVMDYVFQFARSWQPGKAMVVVLEATYTVTDPPLKLLRRFIPPLRLGGVALDLSFFVLMIIVYILISIVSRL
>NZ_CP013743.1|WP_058925846.1|7307730_7308372_+|cell-division-protein-SepF
MAGAMRKMAVYLGLVEDDGYDGRGFDPDDDFEPELDPEPERDHRRHEPSHQSHAAHQSQRDEEVRIVQPSVPREPVARSASLPAESGRPARIAPVASITQERASLEKNAPVIMPKVVSEREPYRITTLHPRTYNEARTIGEHFREGTPVIMNLTEMDDTDAKRLVDFAAGLVFGLHGSIERVTQKVFLLSPANVDVTAEDKARIAEGGFFNQS
>NZ_CP013743.1|WP_058925845.1|7306881_7307601_+|YggS-family-pyridoxal-phosphate-dependent-enzyme
MTDRKDELAANLAKVERRIADACAAVGRARDEVTLIVVTKTYPASDVRILAELGVRHVAENRDQDAAPKAAACSDLPLTWHFVGQLQTNKVRSVVGYADMVQSVDRARLVTALSREAERQERELGCLIQVALDAGESGRGERGGVGPGGIEELGDLVAGAPGLRLAGLMTVAPLTGPYAGREQAAFERLMDLSTDLRRAHPAANMVSAGMSADLEQAVAAGATHVRVGTAVLGVRARLG
>NZ_CP013743.1|WP_107416171.1|7306147_7306876_+|peptidoglycan-editing-factor-PgeF
MTKQRDTVSGAHFAFTDRWGGVSAVPYEELNLGGAVGDDPDAVRTNRELAAGSLGLDPAHVVWMNQVHGADVAVVDGPWGDSPVPEVDAIVTTRRGLALAVLTADCTPVLLADPVAGVVAAAHAGRPGMVAGVVPAALRAMTELGADPARIVARTGPAVCGRCYEVPEQMRAEVAAVEPAAYAETSWGTPAVDVTAGVHAQLDRLGVRDRWQSPACTRESADHFSYRRDRTTGRLAGYVWLD
>NZ_CP013743.1|WP_058925844.1|7304940_7306137_+|cell-division-protein-FtsZ
MAAPQNYLAVIKVIGVGGGGVNAINRMIEVGLKGVEFIAINTDAQALLMSDADVKLDVGRELTRGLGAGANPAVGRKAAEDHREEIEEVLKGADMVFVTAGEGGGTGTGGAPVVANIARSLGALTIGVVTRPFTFEGRRRANQAEDGIAELREEVDTLIVIPNDRLLSISDRQVSVLDAFKSADQVLLSGVQGITDLITTPGLINLDFADVKSVMSEAGSALMGIGSARGDDRAVAAAEMAISSPLLEASIDGARGVLLSISGGSDLGLFEINEAAQLVSEAAHPEANIIFGAVIDDALGDEVRVTVIAAGFDGGQPPARRETVMGSSSSSARREEPTPVRQPESRPSFGSLGSVTPKEDPEPAPEPVADLPVAPPVPPSRSYTDSAAEELDVPDFLK
>NZ_CP013743.1|WP_058925843.1|7303861_7304662_+|FtsQ-type-POTRA-domain-containing-protein
MAGPTTAERGERQQESSGPPLARRLRRLKPPRVRTIIILAVALVLLGAGTVWVLYGSSWTRVERVSVSGTRVLTPAQVREAAEVPVGAPLISVDTGEIETRLRAKLPRIHTVDVVRSWPHGIGLKVVERTPVLIVQKGGKFVEVDDEGVRFATVSQAPKSVPALELRLSRGSAAASLRRFGEARLVREAVRVADAVPAAVARETTTVEVRSYDDILLLLSGGRTVAWGSSERSALKARTLTALMKAAPDARHFDVSVPTAPASSGS
>NZ_CP013743.1|WP_058925842.1|7302737_7303835_+|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase
MHVVLAGGGTAGHIEPALALADALRRQDPTVGITALGTERGLETKLVPQRGYELALIPAVPLPRKPTPELITVPGRLRGTIKATEQILERTKADAVVGFGGYVALPGYLAAKRLGVPIVIHEANARPGLANKIGSRYAAQVAVATPDSKLRNSRYIGIPLRHTIATLDRAAARPEARHMFGLDPNLPTLLVSGGSQGARRLNEVVQQVAPWLQQAGIQILHAVGPKNELPQVQQMPGMPPYIPVSYLDRMDLAYAAADMMLCRAGAMTVAELSAVGLPAAYVPLPIGNGEQRLNAQPVVKAGGGLLVDDAELTPDWVRANVLPVLADPHRLYEMSRAAAEFGRRDADDLLVGMVYEAIAAHRAQH
>NZ_CP013743.1|WP_058925841.1|7301369_7302731_+|putative-lipid-II-flippase-FtsW
MPSSRTGRPPVQRAVRRPAGPRPPRDNPVLRAYLNAKRAWDRPLTAYYLIAGGSFLITVLGLVMVYSASQITALQMSLPGSFFFRKQLLAAVIGGVLLLIASRMPVKLHRALAYPILAGGVFLMALVQVPGIGMSVNGNQNWISLGGSFQIQPSEFGKLALVLWSADLLARKQDKNLLNQWKHMLVPLVPVAFLLLGLIMLGGDMGTAIILTAILFGLLWLAGAPTRLFVGVLSVAATLGVILIKTSPNRMARLACIGATEPKSGVADCWQAVHGIYALASGGIFGSGLGASVEKWGQLPEAHTDFIFAVTGEELGLAGTLSVLALFAALGYAGIRVAGRTEDPFVRYAAGGVTTWIIAQAVINIGAVLGLLPIAGVPLPLFSYGGSALLPTMFAIGLLIAFARDEPAARAALSLRQPRFGRKRAGGAVRDRGPRRWNTMRRRASAARSSGER
>NZ_CP013743.1|WP_058925840.1|7299920_7301348_+|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase
MTSSVPEGSSEFQGKHVSVAGLGVSGIPAAKVLQARGAIVTVVNDGDDARAREQAAELQALGVTVRLGDGATLPEGTELVVTAPGWKPDKPLFEAARAAGVEIWGDVELAWRLRGPDAAPWLAVTGTNGKTTTVQMLASILKAAGLRTAAVGNIGVSLLDAVLGEEQYDVLAVELSSYQLHWAPSLRAHSAAVLNLAPDHLDWHGSMEAYARDKGRIYEGNRVACVYNAADKATEDLVREADVEEGCRAIGFTLGTPGPSQLGVVEGILVDRAFVENRHKNAQELAEVSDVNPPAPHNIANALAAAALARAFGVPAAAVRDGLRNFTPDAHRIAHVADVDGVAYVDDSKATNTHAAEASLAAYESIVWIAGGLAKGATFDELVAKSAKRLRGAVLIGADRALIREALARHAPEVPVVDLDRTDTGAMLAAVQEAKRLAAEGDTVLLAPACASMDMFANYNKRGDAFAEAVRELGA
>NZ_CP013743.1|WP_058925839.1|7298853_7299924_+|phospho-N-acetylmuramoyl-pentapeptide--transferase
MKQILFSGVIGLFLTLVGTPLLIKLLARKGYGQYIRDDGPREHASKRGTPTMGGIAFILATVAAYFLSKVITGQPPTYSGLLVLGLMCGMGLVGFLDDYIKIVKRRSLGLRAKAKMAGQLIVGISFAVLALQFSDARGNTPASTKLSFITDFGWTIGPVLFVVWALFMILAMSNGVNLTDGLDGLATGASVLVFGAYTFIGVWQFQESCANAQTLTNPGACYEVRDPLDLAVIASALMGACLGFLWWNTSPAKIFMGDTGSLALGGVLTGLAICSRTELLVAIMGGLFVLITMSVVIQVGSFRLTGKRVFRMAPLQHHFELKGWSEVLVVVRFWIIQGICVIVGLGLFYAGWAADK
>NZ_CP013743.1|WP_058925849.1|7310172_7313310_-|isoleucine--tRNA-ligase
MTTPTYRQVPAQVDLPALEHAVLDFWREQKIFAKTLEQSEGRPEWVFYEGPPTANGMPGAHHIEARVFKDVFPRFRTMRGHHVARKAGWDCHGLPVELAVEKELGFSGKPDIEKYGIAEFNAKCRESVTRHTDAFTELTTRMGYWVDLDDAYRTMDPEYIESVWWSLKTIFDKGLLVQDHRVAPWCPRCGTGLSDHELAQGYETVVDPSVYVRFPLTSGPLAGEAALLVWTTTPWTLVSNTAVAAHPDVTYVVATNGEEKLVVAEPLVEKALGEGWETTGRSFTGAEMERWTYQRPFELVEFPEPAHYVVNAEYVTTEDGTGLVHQSPAFGEDDLKVCRAYGLPVVNPVRPDGTFEEDVPLVGGVFFKKADEKLTEDLQQRGLLFKHIPYEHSYPHCWRCHTALLYYAQPSWYIRTTAIKDRLLQENENTNWFPDTVKHGRYGDWLNNNIDWALSRNRYWGTPLPIWRCEDEHLTVVGSRAELTELTGTDQSELDPHRPYIDDVAFACPTCEKTATRVPEVIDAWYDSGSMPFAQWGYPYKNKELFESRYPAQFISEAIDQTRGWFYTLMAVGTLVFDKSSYENVVCLGHILAEDGRKMSKHLGNILQPIPLMDQHGADAVRWFMAAGGSPWTARRVGHGTIQEVVRKTLLTYWNTVAFQALYARTSDWAPSEADPAPADRPVLDRWLLSELHALTDQVTQALESYDTQRAGKLLSAFVDDLSNWYVRRSRRRFWQGDKAALRTLHEVVETVTKLMAPLTPFITERVWQDLVVPVTPGAPESVHLASWPEADLTAIDPELSKQMLLVRRLVELGRATRAESGVKTRQPLSRALVAAAGFESLDTELHAQITEELNVSSLASLSEVGGSLVDTTAKANFRALGKRFGKRVQDVAKAVANADAAALSLALREGTASVEVDGETISLAPDEVIITETPREGWSVASDSGATVALDLEITEELRQAGLARDAIRLIQEARKNSGLDVADRIALRWTSTDPAVIAALSEHTGLIADEVLATDFGQGEADDTYGSAFTDEGLSLTFRLRKV
>NZ_CP013743.1|WP_058925850.1|7313905_7315159_+|TraR/DksA-family-transcriptional-regulator
MVAKKTAVQHSAPGRSTQAPGGAAKDVSGKKSARGGAGGRAGGAAKTEQSAEPAKRVRGAAAAKGSGPPPEAEPGPEAKPTSKRAAGKATGAAKAAGAAKTAGAAKAAGAAKATGATKAAGAAKATGAARTAGAAKAAAGKAGAAEAGAKTAAVGKAAAGEAGAGRSGAGKKAAGKKTSARKAAPKKETAAKAVAGEAAGKGAAAATAPRKRAAKKTAARAGGGAGKALAPASAGEKNDSTAKKAGAAQAAEQTGATTVVAKKTPGTATAAKSAVPKARLAAAVEPGELAVRPGEDPWTTEEVEEARAELQSEQQRLSDEISSSEAALQGLMRDSGDGAGDDQADTGTKNITREHEMALAANAREMLTQTEHALQRLDAGTYGLCENCGNPIGKARMQAFPRATLCVECKQKQERRY
>NZ_CP013743.1|WP_063824490.1|7315220_7315796_+|signal-peptidase-II
MAEAERIIGTPDTPEAAGSASRQDTVARPEGRRRIAVLFAVAAFAYLLDLGSKLLVVAKLEHHAPIEVAGDWLKLEAIRNAGAAFGFGEAFTVIFTVIAAAVIVVIVRLARKLYSLPWAIALGLLLGGALGNLTDRIFRSPGVFEGAVVDFIAPKGFAVFNLADSAIVCGGVLIVLLSFRGLDPDGTVHKD
>NZ_CP013743.1|WP_058925852.1|7315902_7316847_+|RluA-family-pseudouridine-synthase
MSTIPEIRTLPVPDGLEGERVDAAISRMFGFSRTKAAELAAAGKVMVDGSVVGKSERVHGGAWLEVEMPQAPAPVQVVAEPVEGMEIVHDDDDVVVIVKPVGVAAHPSPGWTGPTVIGGLAAAGYRISTSGAAERQGIVHRLDVGTSGLMVVAKSEYAYTSLKRQFKERTVDKRYHTLVQGHPDPTSGTIDAPIGRHPQHDYKWAVTAEGKPSVTHYDLIEAFRSASLLDVKLETGRTHQIRVHMAAHRHPCVGDLTYGADPTLAKRLHLTRQWLHAVRLGFEHPGDGQWVEFSSDYPADLQKALDQVREETYG
>NZ_CP013743.1|WP_058925853.1|7316843_7317317_+|GNAT-family-N-acetyltransferase
MSGTPAYEVRVAEDPADLEACFAVRKEVFVGEQGVPEDIEYDAYDAVAVHVLAVREDGFTLGTGRLLHGEAAADKVGGDLSVGSLGRLAVAREARGLGIGVALVRAIEDAARARGLTAVDLHAQTHALGFYERLGYEAYGPEYLEAGIAHRAMRRAL
>NZ_CP013743.1|WP_058925854.1|7317402_7318989_+|Na+/H+-antiporter
MDQLALLFVLLLGAVLSVPVGDRFGLPAPVLMTLLGIVLAVADFVPDVNVPPDLILPLLLPPLLYAAVRRTSWRQFAANVRPIFLLAVALVFVTTVCVAAVAHAVVPGLPVAAAVALGALVAPPDPVAATAVAGQLGLPRRLVSILEGEGLFNDVTAIVLYHVAVAAAVSGEFHAGRAALDLVLSAVVAIAVGVALGWGANRLLDLLGDATLQVGLTLLVPYASYVLAEELHGSGVLAVLTTALFLAEYATDPDDVMTRLAGHTFWDIVDTLVTGVAFGLIGLELHNAIRTASGRWGELLAWSALILGVVVLVRLVYLLPATWLTQRLHARRDHDEDIPAGWRETVVMWWSGMRGVASVALALAIPLKTDAGSAFPDRDEIIFIAFGVIMGTLVLQGLTLPWLVKKLGVQSDTEREKKFERELAVRAAKAAKRRLREIEEVEELPEELSEQMLRRAFEIGVRISPDLGEEERREAHEMRVRRLKRMRRIQGELLSAARHEVLAARNEPGADPEVVDRVLRHLDVRSLR
>NZ_CP013743.1|WP_058925855.1|7319037_7319778_+|SDR-family-oxidoreductase
MARNVVISGGGTGIGLAAARLFAADGDRVLLLGRREEVLKRADVPGASTYAADLGDPAAVRGVADFVAREFGTVDVLVHGAGGNGQLEPPAESADPLDRVAHAWTLTFRINTLTAVLLTEALKDRLASPGGRVLFVSSIAAYRGSGSGAYAGAKAALHPYAHDLARELGPRGITANVVAPGYIEDTEFFGPRIDPARRERLVAETSNGRAGTPGDVAATLHWLASPGAGHVTSQILQVNGGAERGH
>NZ_CP013743.1|WP_058925856.1|7319797_7320901_-|mechanosensitive-ion-channel
MENVLRPLIVIGGSVVLTLFIGWATDLLLRKADQRDSETQLWGLLRRGRFPYQLVLCAALLRGSYDQARLTREHRVAVGQFLTLVLIGAAAWLVIRIAAAIVETSYTRYARAHHDAARVRRVRTQVSLIMRVVTAIVGVVAVAAMLLTFPAMRAAGASLLASAGILGIVAGVAAQSTLSNMFAGLQIAFGDMVRLGDTVVVDGEWGTVEEITLTFLTVRTWDERRITMPVSYFTSKPFENWSRGTPQMTGIVYWHLDHSAPVEEMRAKLRDILRQCPAWDGRDYGLAVTDSTPNTIQVRALVTAKDADDIWTVRVTVREQMVRWLNERHPHALPRVNTAEAVLPPGLVPHQDGHRHRAFETPRTGRG
>NZ_CP013743.1|WP_058925857.1|7321008_7321578_+|dienelactone-hydrolase
MNIMLFHSTYGLRPAVREAADRLRGAGHEVWTPDLFDGRTFETVEEGMAHKDEIGKDELLKRAVLAAAPYSERGLVYAGFSLGASIAQTLALGDDKARGLLLLHGTSDIAPNAAVDELPVQLHVAEPDPFETDDWLSAWYLQMDRAGADVEIYRYAGAGHLYTDPGLPDWDEEAAEATWRVALGFLETL
>NZ_CP013743.1|WP_058925858.1|7321587_7321938_-|hypothetical-protein
MATPQSVLRKTAVLGAALALAGITATTQAQEASAAPAYVNLTVLDVHGAPLYAKPTSSSTRFRVEPFKTTLRIQCSTTKTPSGALWFRLYDSKPQTWVWSGHFESLVHNPKECFPG

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Crispr_ID: NZ_CP013743_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_10

7314165-7314322

Orphan

Consensus_repeat	Method
CGAAGGCTGCGGGGGCTGCGAAG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP013743_10

>merge|NZ_CP013743|10|7314165-7314322|CRISPRCasFinder
GCAAGGCGACGGGGGCCGCGAAGGCTGCGGGGGCTGCGAAGACGGCGGGGGCTGCGAAGGCTGCGGGGGCCGCGAAGGCGACGGGAGCTACGAAGGCTGCGGGGGCCGCGAAGGCGACGGGTGCTGCCCGGACGGCGGGGGCTGCGAAGGCTGCGGCC

>NZ_CP013743|10|8|7314165-7314322|CRISPRCasFinder
GCAAGGCGACGGGGGCCGCGAAG	GCTGCGGGGGCTGCGAAGACGG
CGGGGGCTGCGAAGGCTGCGGGG	GCCGCGAAGGCGACGGGAGCTA
CGAAGGCTGCGGGGGCCGCGAAG	GCGACGGGTGCTGCCCGGACGG
CGGGGGCTGCGAAGGCTGCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_058925855.1\|7319037_7319778_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP013743.1\|WP_058925847.1\|7308444_7308729_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|376765
NZ_CP013743.1\|WP_058925859.1\|7322041_7323712_-\|alkaline-phosphatase	unknown	unknown	gnl\|CDD\|226070
NZ_CP013743.1\|WP_058925857.1\|7321008_7321578_+\|dienelactone-hydrolase	unknown	unknown	gnl\|CDD\|223489
NZ_CP013743.1\|WP_058925856.1\|7319797_7320901_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|366370
NZ_CP013743.1\|WP_058925858.1\|7321587_7321938_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_107416171.1\|7306147_7306876_+\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|376831
NZ_CP013743.1\|WP_063824490.1\|7315220_7315796_+\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|237810
NZ_CP013743.1\|WP_058925852.1\|7315902_7316847_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP013743.1\|WP_058925860.1\|7323804_7324617_-\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|372611
NZ_CP013743.1\|WP_058925854.1\|7317402_7318989_+\|Na+/H+-antiporter	unknown	unknown	gnl\|CDD\|129911
NZ_CP013743.1\|WP_058925848.1\|7308782_7309997_+\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377456
NZ_CP013743.1\|WP_058925845.1\|7306881_7307601_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|143483
NZ_CP013743.1\|WP_058925843.1\|7303861_7304662_+\|FtsQ-type-POTRA-domain-containing-protein	unknown	unknown	gnl\|CDD\|135428
NZ_CP013743.1\|WP_058925846.1\|7307730_7308372_+\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|377370
NZ_CP013743.1\|WP_058925841.1\|7301369_7302731_+\|putative-lipid-II-flippase-FtsW	unknown	unknown	gnl\|CDD\|274232
NZ_CP013743.1\|WP_058925849.1\|7310172_7313310_-\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235681
NZ_CP013743.1\|WP_058925842.1\|7302737_7303835_+\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	unknown	unknown	gnl\|CDD\|234825
NZ_CP013743.1\|WP_058925853.1\|7316843_7317317_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225064
NZ_CP013743.1\|WP_058925844.1\|7304940_7306137_+\|cell-division-protein-FtsZ	unknown	unknown	gnl\|CDD\|236468

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_058925855.1\|7319037_7319778_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.0555e-54
NZ_CP013743.1\|WP_058925847.1\|7308444_7308729_+\|YggT-family-protein	gnl\|CDD\|376765	pfam02325, YGGT, YGGT family. This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown.	0.000436233
NZ_CP013743.1\|WP_058925859.1\|7322041_7323712_-\|alkaline-phosphatase	gnl\|CDD\|226070	COG3540, PhoD, Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism].	2.56637e-143
NZ_CP013743.1\|WP_058925857.1\|7321008_7321578_+\|dienelactone-hydrolase	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	6.81853e-19
NZ_CP013743.1\|WP_058925856.1\|7319797_7320901_-\|mechanosensitive-ion-channel	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	7.13687e-27
NZ_CP013743.1\|WP_107416171.1\|7306147_7306876_+\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|376831	pfam02578, Cu-oxidase_4, Multi-copper polyphenol oxidoreductase laccase. Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.	1.98191e-85
NZ_CP013743.1\|WP_063824490.1\|7315220_7315796_+\|signal-peptidase-II	gnl\|CDD\|237810	PRK14764, PRK14764, lipoprotein signal peptidase; Provisional.	5.7044e-90
NZ_CP013743.1\|WP_058925852.1\|7315902_7316847_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.67961e-101
NZ_CP013743.1\|WP_058925860.1\|7323804_7324617_-\|thioredoxin-domain-containing-protein	gnl\|CDD\|372611	pfam13462, Thioredoxin_4, Thioredoxin.	1.75588e-31
NZ_CP013743.1\|WP_058925854.1\|7317402_7318989_+\|Na+/H+-antiporter	gnl\|CDD\|129911	TIGR00831, Putative_Na+/H+_exchanger_Rv2287/MT2345/Mb2309., Na+/H+ antiporter, bacterial form. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds].	3.77482e-85
NZ_CP013743.1\|WP_058925848.1\|7308782_7309997_+\|DivIVA-domain-containing-protein	gnl\|CDD\|377456	pfam05103, DivIVA, DivIVA protein. The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype. These proteins appear to contain coiled-coils.	1.42247e-16
NZ_CP013743.1\|WP_058925845.1\|7306881_7307601_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|143483	cd00635, PLPDE_III_YBL036c_like, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins. This family contains mostly uncharacterized proteins, widely distributed among eukaryotes, bacteria and archaea, that bear similarity to the yeast hypothetical protein YBL036c, which is homologous to a Pseudomonas aeruginosa gene that is co-transcribed with a known proline biosynthetic gene. YBL036c is a single domain monomeric protein with a typical TIM barrel fold. It binds the PLP cofactor and has been shown to exhibit amino acid racemase activity. The YBL036c structure is similar to the N-terminal domain of the fold type III PLP-dependent enzymes, bacterial alanine racemase and eukaryotic ornithine decarboxylase, which are two-domain dimeric proteins. The lack of a second domain in YBL036c may explain limited D- to L-alanine racemase or non-specific racemase activity.	7.25305e-77
NZ_CP013743.1\|WP_058925843.1\|7303861_7304662_+\|FtsQ-type-POTRA-domain-containing-protein	gnl\|CDD\|135428	PRK05529, PRK05529, cell division protein FtsQ; Provisional.	2.42544e-23
NZ_CP013743.1\|WP_058925846.1\|7307730_7308372_+\|cell-division-protein-SepF	gnl\|CDD\|377370	pfam04472, SepF, Cell division protein SepF. SepF accumulates at the cell division site in an FtsZ-dependent manner and is required for proper septum formation. Mutants are viable but the formation of the septum is much slower and occurs with a very abnormal morphology. This family also includes archaeal related proteins of unknown function.	1.06835e-30
NZ_CP013743.1\|WP_058925841.1\|7301369_7302731_+\|putative-lipid-II-flippase-FtsW	gnl\|CDD\|274232	TIGR02614, Putative_lipid_II_flippase_FtsW, cell division protein FtsW. This family consists of FtsW, an integral membrane protein with ten transmembrane segments. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	1.25549e-131
NZ_CP013743.1\|WP_058925849.1\|7310172_7313310_-\|isoleucine--tRNA-ligase	gnl\|CDD\|235681	PRK06039, ileS, isoleucyl-tRNA synthetase; Reviewed.	0
NZ_CP013743.1\|WP_058925842.1\|7302737_7303835_+\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	gnl\|CDD\|234825	PRK00726, murG, undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional.	3.46025e-139
NZ_CP013743.1\|WP_058925853.1\|7316843_7317317_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225064	COG2153, ElaA, Predicted acyltransferase [General function prediction only].	5.21544e-20
NZ_CP013743.1\|WP_058925844.1\|7304940_7306137_+\|cell-division-protein-FtsZ	gnl\|CDD\|236468	PRK09330, PRK09330, cell division protein FtsZ; Validated.	0

>NZ_CP013743.1|WP_058925849.1|7310172_7313310_-|isoleucine--tRNA-ligase
MTTPTYRQVPAQVDLPALEHAVLDFWREQKIFAKTLEQSEGRPEWVFYEGPPTANGMPGAHHIEARVFKDVFPRFRTMRGHHVARKAGWDCHGLPVELAVEKELGFSGKPDIEKYGIAEFNAKCRESVTRHTDAFTELTTRMGYWVDLDDAYRTMDPEYIESVWWSLKTIFDKGLLVQDHRVAPWCPRCGTGLSDHELAQGYETVVDPSVYVRFPLTSGPLAGEAALLVWTTTPWTLVSNTAVAAHPDVTYVVATNGEEKLVVAEPLVEKALGEGWETTGRSFTGAEMERWTYQRPFELVEFPEPAHYVVNAEYVTTEDGTGLVHQSPAFGEDDLKVCRAYGLPVVNPVRPDGTFEEDVPLVGGVFFKKADEKLTEDLQQRGLLFKHIPYEHSYPHCWRCHTALLYYAQPSWYIRTTAIKDRLLQENENTNWFPDTVKHGRYGDWLNNNIDWALSRNRYWGTPLPIWRCEDEHLTVVGSRAELTELTGTDQSELDPHRPYIDDVAFACPTCEKTATRVPEVIDAWYDSGSMPFAQWGYPYKNKELFESRYPAQFISEAIDQTRGWFYTLMAVGTLVFDKSSYENVVCLGHILAEDGRKMSKHLGNILQPIPLMDQHGADAVRWFMAAGGSPWTARRVGHGTIQEVVRKTLLTYWNTVAFQALYARTSDWAPSEADPAPADRPVLDRWLLSELHALTDQVTQALESYDTQRAGKLLSAFVDDLSNWYVRRSRRRFWQGDKAALRTLHEVVETVTKLMAPLTPFITERVWQDLVVPVTPGAPESVHLASWPEADLTAIDPELSKQMLLVRRLVELGRATRAESGVKTRQPLSRALVAAAGFESLDTELHAQITEELNVSSLASLSEVGGSLVDTTAKANFRALGKRFGKRVQDVAKAVANADAAALSLALREGTASVEVDGETISLAPDEVIITETPREGWSVASDSGATVALDLEITEELRQAGLARDAIRLIQEARKNSGLDVADRIALRWTSTDPAVIAALSEHTGLIADEVLATDFGQGEADDTYGSAFTDEGLSLTFRLRKV
>NZ_CP013743.1|WP_058925848.1|7308782_7309997_+|DivIVA-domain-containing-protein
MPLTPEDVRNKQFTTVRLREGYDEDEVDAFLDEVEAELTRLLRENEDLRAKLAAATRAAAQNQQNMRKPPEGPGGPQDQQQGGMPQQGGMPQQGGMPQQGMRGPGAPVPAGISGPPQQQMGGPMGGPPQLPSGAPQLPAGPGGQGGPQGPGPMGQGPMGQGPMGQGQMGQGQMGGPMGQPPMQQQMGGPMGGPMGGPMGGPGQGPGGDSAARVLSLAQQTADQAIAEARSEANKIVGEARSRAEGLERDARAKADALERDAQEKHRVAMGSLESARATLERKVEDLRGFEREYRTRLKSYLESQLRQLETQADDSLAPPRTPATASLPPSPAPSMAPAGASAPSYGGNQSMGGAPSPAGPSYGGQQQMSPAMTQPMAPVRPQGPSPMGQAPSPMRGFLIDEDDN
>NZ_CP013743.1|WP_058925847.1|7308444_7308729_+|YggT-family-protein
MSVVLQVIYIALMCFLIVLIFRLVMDYVFQFARSWQPGKAMVVVLEATYTVTDPPLKLLRRFIPPLRLGGVALDLSFFVLMIIVYILISIVSRL
>NZ_CP013743.1|WP_058925846.1|7307730_7308372_+|cell-division-protein-SepF
MAGAMRKMAVYLGLVEDDGYDGRGFDPDDDFEPELDPEPERDHRRHEPSHQSHAAHQSQRDEEVRIVQPSVPREPVARSASLPAESGRPARIAPVASITQERASLEKNAPVIMPKVVSEREPYRITTLHPRTYNEARTIGEHFREGTPVIMNLTEMDDTDAKRLVDFAAGLVFGLHGSIERVTQKVFLLSPANVDVTAEDKARIAEGGFFNQS
>NZ_CP013743.1|WP_058925845.1|7306881_7307601_+|YggS-family-pyridoxal-phosphate-dependent-enzyme
MTDRKDELAANLAKVERRIADACAAVGRARDEVTLIVVTKTYPASDVRILAELGVRHVAENRDQDAAPKAAACSDLPLTWHFVGQLQTNKVRSVVGYADMVQSVDRARLVTALSREAERQERELGCLIQVALDAGESGRGERGGVGPGGIEELGDLVAGAPGLRLAGLMTVAPLTGPYAGREQAAFERLMDLSTDLRRAHPAANMVSAGMSADLEQAVAAGATHVRVGTAVLGVRARLG
>NZ_CP013743.1|WP_107416171.1|7306147_7306876_+|peptidoglycan-editing-factor-PgeF
MTKQRDTVSGAHFAFTDRWGGVSAVPYEELNLGGAVGDDPDAVRTNRELAAGSLGLDPAHVVWMNQVHGADVAVVDGPWGDSPVPEVDAIVTTRRGLALAVLTADCTPVLLADPVAGVVAAAHAGRPGMVAGVVPAALRAMTELGADPARIVARTGPAVCGRCYEVPEQMRAEVAAVEPAAYAETSWGTPAVDVTAGVHAQLDRLGVRDRWQSPACTRESADHFSYRRDRTTGRLAGYVWLD
>NZ_CP013743.1|WP_058925844.1|7304940_7306137_+|cell-division-protein-FtsZ
MAAPQNYLAVIKVIGVGGGGVNAINRMIEVGLKGVEFIAINTDAQALLMSDADVKLDVGRELTRGLGAGANPAVGRKAAEDHREEIEEVLKGADMVFVTAGEGGGTGTGGAPVVANIARSLGALTIGVVTRPFTFEGRRRANQAEDGIAELREEVDTLIVIPNDRLLSISDRQVSVLDAFKSADQVLLSGVQGITDLITTPGLINLDFADVKSVMSEAGSALMGIGSARGDDRAVAAAEMAISSPLLEASIDGARGVLLSISGGSDLGLFEINEAAQLVSEAAHPEANIIFGAVIDDALGDEVRVTVIAAGFDGGQPPARRETVMGSSSSSARREEPTPVRQPESRPSFGSLGSVTPKEDPEPAPEPVADLPVAPPVPPSRSYTDSAAEELDVPDFLK
>NZ_CP013743.1|WP_058925843.1|7303861_7304662_+|FtsQ-type-POTRA-domain-containing-protein
MAGPTTAERGERQQESSGPPLARRLRRLKPPRVRTIIILAVALVLLGAGTVWVLYGSSWTRVERVSVSGTRVLTPAQVREAAEVPVGAPLISVDTGEIETRLRAKLPRIHTVDVVRSWPHGIGLKVVERTPVLIVQKGGKFVEVDDEGVRFATVSQAPKSVPALELRLSRGSAAASLRRFGEARLVREAVRVADAVPAAVARETTTVEVRSYDDILLLLSGGRTVAWGSSERSALKARTLTALMKAAPDARHFDVSVPTAPASSGS
>NZ_CP013743.1|WP_058925842.1|7302737_7303835_+|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase
MHVVLAGGGTAGHIEPALALADALRRQDPTVGITALGTERGLETKLVPQRGYELALIPAVPLPRKPTPELITVPGRLRGTIKATEQILERTKADAVVGFGGYVALPGYLAAKRLGVPIVIHEANARPGLANKIGSRYAAQVAVATPDSKLRNSRYIGIPLRHTIATLDRAAARPEARHMFGLDPNLPTLLVSGGSQGARRLNEVVQQVAPWLQQAGIQILHAVGPKNELPQVQQMPGMPPYIPVSYLDRMDLAYAAADMMLCRAGAMTVAELSAVGLPAAYVPLPIGNGEQRLNAQPVVKAGGGLLVDDAELTPDWVRANVLPVLADPHRLYEMSRAAAEFGRRDADDLLVGMVYEAIAAHRAQH
>NZ_CP013743.1|WP_058925841.1|7301369_7302731_+|putative-lipid-II-flippase-FtsW
MPSSRTGRPPVQRAVRRPAGPRPPRDNPVLRAYLNAKRAWDRPLTAYYLIAGGSFLITVLGLVMVYSASQITALQMSLPGSFFFRKQLLAAVIGGVLLLIASRMPVKLHRALAYPILAGGVFLMALVQVPGIGMSVNGNQNWISLGGSFQIQPSEFGKLALVLWSADLLARKQDKNLLNQWKHMLVPLVPVAFLLLGLIMLGGDMGTAIILTAILFGLLWLAGAPTRLFVGVLSVAATLGVILIKTSPNRMARLACIGATEPKSGVADCWQAVHGIYALASGGIFGSGLGASVEKWGQLPEAHTDFIFAVTGEELGLAGTLSVLALFAALGYAGIRVAGRTEDPFVRYAAGGVTTWIIAQAVINIGAVLGLLPIAGVPLPLFSYGGSALLPTMFAIGLLIAFARDEPAARAALSLRQPRFGRKRAGGAVRDRGPRRWNTMRRRASAARSSGER
>NZ_CP013743.1|WP_063824490.1|7315220_7315796_+|signal-peptidase-II
MAEAERIIGTPDTPEAAGSASRQDTVARPEGRRRIAVLFAVAAFAYLLDLGSKLLVVAKLEHHAPIEVAGDWLKLEAIRNAGAAFGFGEAFTVIFTVIAAAVIVVIVRLARKLYSLPWAIALGLLLGGALGNLTDRIFRSPGVFEGAVVDFIAPKGFAVFNLADSAIVCGGVLIVLLSFRGLDPDGTVHKD
>NZ_CP013743.1|WP_058925852.1|7315902_7316847_+|RluA-family-pseudouridine-synthase
MSTIPEIRTLPVPDGLEGERVDAAISRMFGFSRTKAAELAAAGKVMVDGSVVGKSERVHGGAWLEVEMPQAPAPVQVVAEPVEGMEIVHDDDDVVVIVKPVGVAAHPSPGWTGPTVIGGLAAAGYRISTSGAAERQGIVHRLDVGTSGLMVVAKSEYAYTSLKRQFKERTVDKRYHTLVQGHPDPTSGTIDAPIGRHPQHDYKWAVTAEGKPSVTHYDLIEAFRSASLLDVKLETGRTHQIRVHMAAHRHPCVGDLTYGADPTLAKRLHLTRQWLHAVRLGFEHPGDGQWVEFSSDYPADLQKALDQVREETYG
>NZ_CP013743.1|WP_058925853.1|7316843_7317317_+|GNAT-family-N-acetyltransferase
MSGTPAYEVRVAEDPADLEACFAVRKEVFVGEQGVPEDIEYDAYDAVAVHVLAVREDGFTLGTGRLLHGEAAADKVGGDLSVGSLGRLAVAREARGLGIGVALVRAIEDAARARGLTAVDLHAQTHALGFYERLGYEAYGPEYLEAGIAHRAMRRAL
>NZ_CP013743.1|WP_058925854.1|7317402_7318989_+|Na+/H+-antiporter
MDQLALLFVLLLGAVLSVPVGDRFGLPAPVLMTLLGIVLAVADFVPDVNVPPDLILPLLLPPLLYAAVRRTSWRQFAANVRPIFLLAVALVFVTTVCVAAVAHAVVPGLPVAAAVALGALVAPPDPVAATAVAGQLGLPRRLVSILEGEGLFNDVTAIVLYHVAVAAAVSGEFHAGRAALDLVLSAVVAIAVGVALGWGANRLLDLLGDATLQVGLTLLVPYASYVLAEELHGSGVLAVLTTALFLAEYATDPDDVMTRLAGHTFWDIVDTLVTGVAFGLIGLELHNAIRTASGRWGELLAWSALILGVVVLVRLVYLLPATWLTQRLHARRDHDEDIPAGWRETVVMWWSGMRGVASVALALAIPLKTDAGSAFPDRDEIIFIAFGVIMGTLVLQGLTLPWLVKKLGVQSDTEREKKFERELAVRAAKAAKRRLREIEEVEELPEELSEQMLRRAFEIGVRISPDLGEEERREAHEMRVRRLKRMRRIQGELLSAARHEVLAARNEPGADPEVVDRVLRHLDVRSLR
>NZ_CP013743.1|WP_058925855.1|7319037_7319778_+|SDR-family-oxidoreductase
MARNVVISGGGTGIGLAAARLFAADGDRVLLLGRREEVLKRADVPGASTYAADLGDPAAVRGVADFVAREFGTVDVLVHGAGGNGQLEPPAESADPLDRVAHAWTLTFRINTLTAVLLTEALKDRLASPGGRVLFVSSIAAYRGSGSGAYAGAKAALHPYAHDLARELGPRGITANVVAPGYIEDTEFFGPRIDPARRERLVAETSNGRAGTPGDVAATLHWLASPGAGHVTSQILQVNGGAERGH
>NZ_CP013743.1|WP_058925856.1|7319797_7320901_-|mechanosensitive-ion-channel
MENVLRPLIVIGGSVVLTLFIGWATDLLLRKADQRDSETQLWGLLRRGRFPYQLVLCAALLRGSYDQARLTREHRVAVGQFLTLVLIGAAAWLVIRIAAAIVETSYTRYARAHHDAARVRRVRTQVSLIMRVVTAIVGVVAVAAMLLTFPAMRAAGASLLASAGILGIVAGVAAQSTLSNMFAGLQIAFGDMVRLGDTVVVDGEWGTVEEITLTFLTVRTWDERRITMPVSYFTSKPFENWSRGTPQMTGIVYWHLDHSAPVEEMRAKLRDILRQCPAWDGRDYGLAVTDSTPNTIQVRALVTAKDADDIWTVRVTVREQMVRWLNERHPHALPRVNTAEAVLPPGLVPHQDGHRHRAFETPRTGRG
>NZ_CP013743.1|WP_058925857.1|7321008_7321578_+|dienelactone-hydrolase
MNIMLFHSTYGLRPAVREAADRLRGAGHEVWTPDLFDGRTFETVEEGMAHKDEIGKDELLKRAVLAAAPYSERGLVYAGFSLGASIAQTLALGDDKARGLLLLHGTSDIAPNAAVDELPVQLHVAEPDPFETDDWLSAWYLQMDRAGADVEIYRYAGAGHLYTDPGLPDWDEEAAEATWRVALGFLETL
>NZ_CP013743.1|WP_058925858.1|7321587_7321938_-|hypothetical-protein
MATPQSVLRKTAVLGAALALAGITATTQAQEASAAPAYVNLTVLDVHGAPLYAKPTSSSTRFRVEPFKTTLRIQCSTTKTPSGALWFRLYDSKPQTWVWSGHFESLVHNPKECFPG
>NZ_CP013743.1|WP_058925859.1|7322041_7323712_-|alkaline-phosphatase
MTSRYRTSEASQPPNSLSPRRRTVVKAAAATAVLAGPLAAALPARAAAETPQFLHGVASGDPLPDGVLLWTRVTPTAEATPGSGLGPDTEVGWVVATDRALTNIVAKGSVTATAASDHTVKADIRGLRPATDYWFRFSAGGTDSPVARTRTAPAADAAVTSLRFGVVSCANWEGGYFASYRHLADRGDLDAWLHLGDYIYEYKSGEYAARGTVVRPHAPANEIITLADYRTRHGKYKTDPDLQALHLKAPVVAIWDDHEFADNAWSGGAVNHTEGAEGAWTDRKAAAKQAYFEWMPVRPAIAGTTYRRLRFGKLADLSLLDLRSFRSQQASSGSGSVDDPDRTITGRAQLDWLKAGLKASDTTWRLVGNSVMIAPFVVGSLSADLLKPLAKLLGLPQEGLAVNTDQWDGYTDDRRELLAHLRSNAIRNTVFLTGDIHMAWANDVPVDAGTYPLSASAATEFVVTSVTSDNLDDIVKVPEGTVSAIAAPVIRAANRHVHWVDTDRHGYGVLDITADRAQMDYYVLSDRTDRNATSTWVRSYRTRSGTQKVERTYDPV
>NZ_CP013743.1|WP_058925860.1|7323804_7324617_-|thioredoxin-domain-containing-protein
MSKRNSQTAKTAARERLRVERERQAKRAKAKRQVIVACSIVAVLAAAGGIGYAVVQANKPSYWEGLKDAKVVAPAHTTGAKGTTVVIGKSNAKTLKVYEDPRCPICASFEQTVGSTVKKDIDGGKYKIQYIGATFIDNKDNGQGSKNALSALGAALNVSDEAFLQYKSAMYSAKWHPDETTDKFKDDSYLIKIANTVPALKDNTQFQNAVKKGTYDAWAVAMSKTFDTNKDGVTGTPGFVMNGKQLTSSDQNQGWTVATFNQAVDAALKG

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Crispr_ID: NZ_CP013743_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_11

7443066-7443150

Orphan

Consensus_repeat	Method
GGCCGAGCAGCGGTGCCACGACTGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013743_11

>merge|NZ_CP013743|11|7443066-7443150|CRISPRCasFinder
GGCCGAGCAGCGGTGCCACGACTGCCCGAGCTGTCCCTGGGCCCGGGTAGGGGCGGCCGGCCCAGCAGCGGTGCCACGACTGCCC

>NZ_CP013743|11|9|7443066-7443150|CRISPRCasFinder
GGCCGAGCAGCGGTGCCACGACTGCCC	GAGCTGTCCCTGGGCCCGGGTAGGGGCGGCC
GGCCCAGCAGCGGTGCCACGACTGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_058925962.1\|7448602_7450552_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP013743.1\|WP_058925948.1\|7433698_7434226_-\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|224109
NZ_CP013743.1\|WP_058925954.1\|7439051_7440020_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293840
NZ_CP013743.1\|WP_058925952.1\|7436836_7438300_+\|NCS1-family-nucleobase:cation-symporter-1	unknown	unknown	gnl\|CDD\|271404
NZ_CP013743.1\|WP_058925959.1\|7445330_7446104_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369778
NZ_CP013743.1\|WP_058925961.1\|7447566_7448256_+\|DUF899-domain-containing-protein	unknown	unknown	gnl\|CDD\|377584
NZ_CP013743.1\|WP_058925949.1\|7434301_7434994_+\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|381681
NZ_CP013743.1\|WP_058925960.1\|7446123_7447077_-\|endonuclease	unknown	unknown	gnl\|CDD\|197338
NZ_CP013743.1\|WP_058925963.1\|7451613_7452048_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058928477.1\|7448413_7448596_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058925953.1\|7438305_7439046_+\|Asp/Glu/hydantoin-racemase	unknown	unknown	gnl\|CDD\|226611
NZ_CP013743.1\|WP_079078182.1\|7443838_7445164_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP013743.1\|WP_058925957.1\|7441200_7443060_+\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|379231
NZ_CP013743.1\|WP_058925965.1\|7452930_7453791_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP013743.1\|WP_058925956.1\|7440479_7440893_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|223329
NZ_CP013743.1\|WP_058925951.1\|7436010_7436673_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP013743.1\|WP_058925950.1\|7435032_7435995_+\|prolyl-aminopeptidase	unknown	unknown	gnl\|CDD\|130316
NZ_CP013743.1\|WP_107416306.1\|7443212_7443773_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP013743.1\|WP_058925955.1\|7440021_7440483_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP013743.1\|WP_058925964.1\|7452044_7452704_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_058925962.1\|7448602_7450552_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.46392e-82
NZ_CP013743.1\|WP_058925948.1\|7433698_7434226_-\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	2.3271e-28
NZ_CP013743.1\|WP_058925954.1\|7439051_7440020_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293840	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	4.81948e-59
NZ_CP013743.1\|WP_058925952.1\|7436836_7438300_+\|NCS1-family-nucleobase:cation-symporter-1	gnl\|CDD\|271404	cd11555, SLC-NCS1sbd_u1, uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	0
NZ_CP013743.1\|WP_058925959.1\|7445330_7446104_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369778	pfam08242, Methyltransf_12, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	7.42667e-15
NZ_CP013743.1\|WP_058925961.1\|7447566_7448256_+\|DUF899-domain-containing-protein	gnl\|CDD\|377584	pfam05988, DUF899, Bacterial protein of unknown function (DUF899). This family consists of several uncharacterized bacterial proteins of unknown function.	2.54709e-107
NZ_CP013743.1\|WP_058925949.1\|7434301_7434994_+\|uracil-DNA-glycosylase	gnl\|CDD\|381681	cd10031, UDG-F5_TTUDGB_like, Uracil DNA glycosylase family 5, includes Thermotoga maritima TTUDGB and similar proteins. Uracil DNA glycosylase family 5 includes Thermus thermophilus HB8 TTUDGB (also called UDGb) which is not only a UDG acting on double-stranded uracil-containing DNA, but also a hypoxanthine DNA glycosylase acting on double-stranded hypoxanthine-containing DNA (except for the C/I base pair), as well as a xanthine DNA glycosylase acting on both, double-stranded and single-stranded xanthine-containing DNA. TTUDGB also excises thymine from G:T mismatched DNA, and removes analogs of uracil from DNA, including 5-hydroxymethyluracil (hmU) and 5-fluorouracil (fU). This subfamily also contains Bradyrhizobium diazoefficiens family 5 homolog Blr5068 (UdgB) which has been found to efficiently excise uracil from ssDNA and dsDNA. Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Similar to family 4 UDGs, members of this family possess four conserved cysteine residues required to coordinate the [4Fe-4S] iron-sulfur cluster. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.	8.2104e-116
NZ_CP013743.1\|WP_058925960.1\|7446123_7447077_-\|endonuclease	gnl\|CDD\|197338	cd10283, MnuA_DNase1-like, Mycoplasma pulmonis MnuA nuclease-like. This subfamily includes Mycoplasma pulmonis MnuA, a membrane-associated nuclease related to Deoxyribonuclease 1 (DNase1 or DNase I, EC 3.1.21.1). The in vivo role of MnuA is as yet undetermined. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.	2.08694e-19
NZ_CP013743.1\|WP_058925953.1\|7438305_7439046_+\|Asp/Glu/hydantoin-racemase	gnl\|CDD\|226611	COG4126, COG4126, Hydantoin racemase [Amino acid transport and metabolism].	5.08924e-55
NZ_CP013743.1\|WP_079078182.1\|7443838_7445164_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	4.66466e-49
NZ_CP013743.1\|WP_058925957.1\|7441200_7443060_+\|FUSC-family-protein	gnl\|CDD\|379231	pfam13515, FUSC_2, Fusaric acid resistance protein-like.	2.11083e-13
NZ_CP013743.1\|WP_058925965.1\|7452930_7453791_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	3.87239e-07
NZ_CP013743.1\|WP_058925956.1\|7440479_7440893_-\|RidA-family-protein	gnl\|CDD\|223329	COG0251, TdcF, Putative translation initiation inhibitor, yjgF family [Translation, ribosomal structure and biogenesis].	2.34576e-19
NZ_CP013743.1\|WP_058925951.1\|7436010_7436673_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	2.4421e-46
NZ_CP013743.1\|WP_058925950.1\|7435032_7435995_+\|prolyl-aminopeptidase	gnl\|CDD\|130316	TIGR01249, Putative_proline_iminopeptidase, proline iminopeptidase, Neisseria-type subfamily. This model represents one of two related families of proline iminopeptidase in the alpha/beta fold hydrolase family. The fine specificities of the various members, including both the range of short peptides from which proline can be removed and whether other amino acids such as alanine can be also removed, may vary among members.	8.64583e-97
NZ_CP013743.1\|WP_107416306.1\|7443212_7443773_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.51323e-58
NZ_CP013743.1\|WP_058925955.1\|7440021_7440483_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.03888e-16
NZ_CP013743.1\|WP_058925964.1\|7452044_7452704_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	3.98198e-15

>NZ_CP013743.1|WP_058925957.1|7441200_7443060_+|FUSC-family-protein
MSRPAPAFRLPPWLAHALRAQRAPVSWSAVTRGALSAGPLLLTAVLLDRTALGVIAAIAAMLAGINDRPGSRRASVKRLGLPALAGAAGLLVGTYAGVHADPVVLTLLFTGIGLLAGGVSAVGPVASGAGTQLLVASAVGAGMPAPEAGWARALAFVAGAGWLLGLRLLLPTPGATAGDFRFDGERVAVAAVYDAVADLLDAAGTEAAVARRVALTAALDHAQDALAGPRLRRYASSSAERRLHAQYAAALPLAEAATALAWAGEPVTGRTSEGPRRLAAAVRENTHTGPLPAPHRSVPALRALDDALLHAADAFDRGSGGDLHTRNRSVRDLLRVAFGAGGREYGLRVALCFGASAAVAQALHHARWYGQHTHWYWLPATAVFLVKPDLGPLASRVLSRAAGTVLGALLFAGFAAVLPRPEGLVVLVTLCGALIPVSTRHFAAQTTVVTVLVLALVMVGGEPQASVSRIGETLLACAIVLVVGHLPMPGQRGGGVRARLAAAGDATQAYLAHVLSESADRATRWTLRREAYRALAEARAAIALTAAELPPLARHSEGADEVVASLERLADAITACAVHLDDSGHLSAHDREQIAALLAELAKDGERARLRLPEVLLAG
>NZ_CP013743.1|WP_058925956.1|7440479_7440893_-|RidA-family-protein
MIRRVTSPSLFPPPRYSHASVVEAGSRLAFLAGAVPLDSEGKVIGEGDPVRQAEQVLVNLGEQLRAVGSDFAHVVATDVYVVSGDTSVLSAVWDVVEASGLGLGPHSSTLLGVNCLGYSGQLVEITAIAVVPEAVAS
>NZ_CP013743.1|WP_058925955.1|7440021_7440483_-|GNAT-family-N-acetyltransferase
MSPSQPPAVLRRATAPDALAAADVWLDSFAAALPTVVSPRSADEVRAYFRDVVVPSRETWVAEAADRIVGVMVLAGDELSQLYLSPDWRGRGIGDRFVALAKERSPGGLELWTFQVNKPAHRFYERHGFVAVEYTDGSGNEEREPDVRYAWRP
>NZ_CP013743.1|WP_058925954.1|7439051_7440020_+|MBL-fold-metallo-hydrolase
MNLPDALTPVADGLHLWAPPHTGTWGFANCLLITSGKRAALVDTPYDRPMTEAMIAAARPVLPAGAAGIGTIVNTHVNGDHTFGNGLFPGAEIIATEASAEHLCREPSPQQMHFLTTGTPADQPLGWYAREHFGRYRYEDVEAVPPTVTFSGRYDLEVGGIRAELIEVGPAHSAGDLIVHLPEQRVVCAGDVLFADDHPVHWDGPLARIAAACETILALEPQTVIPGHGPVMGPRDVRDYVTYLRRLEALVHDRHAAGVPAGEAAADILDSGFYDHLGLRERIVILTAVEFRHLNGETGEPDLVGLAAQAAGWAFGRRQAAA
>NZ_CP013743.1|WP_058925953.1|7438305_7439046_+|Asp/Glu/hydantoin-racemase
MRIVVTNCNTTQEMTAEIVRGARAAAGPGTTVRGLTPAWGPESAEGWLDSHLSAAAVIDLLRTYDGPAYDAVVLAGFGEHGREGVRELVDVPVVDITEAAAHLACLLGRRYGVVTTLERSCGQIEDSLELAGVGRNCAAVVGTGLGVLDLGDADRTEAAFLSAAERAREAGAEVLVLGCAGMTGLQRAVGEKLGLPVVDGVGAAVKLAESLVALGLTTSRAGSYAKPVPKRRVWGRLPEGDRPRPQ
>NZ_CP013743.1|WP_058925952.1|7436836_7438300_+|NCS1-family-nucleobase:cation-symporter-1
MSLADRAAATGAPAFVPDPRLTNEDLAPAGKRNWKVFDLFAMWMSDVHNLGNYTFAAGLLVLGMNVWQVFTALLVGFVLIYVGMNWMGRIGQRHGVPFPVVSRISFGVWGANIPALIRAVIAIMWYGIQTYLASVAVNVMLLAAFPELVSWTHHSFLGLDALGWCSFVSLWLIQALIISQGMESVRKFQDFCGPAIWLVMIALAVWVLWKADWSISLTSTPHPVPVGEQWRQWFGAIGLILATYGTLMLNFCDFSRFAPDYRTVRRGNFWGLPVNSTAFVVVSVIVTAGSLEAFGTAITDPAELVAKIGNTWVLVVAAFTFAVATMGVNIVANFVSPAYDLANVWPQKITFRIGGMISTVAALVVTPWNLFSNPTVVNYFLGGLGAFLGPLFGVIMVDYHLIKRGRVNVDELFDARPGSRYYYKKGVNPKALWAFLPSAAVAAVLALVKSFSDVAPYSWFIGTALAAGLYLLICRTERASEPAAVEV
>NZ_CP013743.1|WP_058925951.1|7436010_7436673_-|GntR-family-transcriptional-regulator
MSSPTKTEPLGAVRERVLANLRQEIIAGRLLPGDRLVERELADRYGVSRVPVREAIRALVAEGFVHFETPRRTVVRRLTPNDVRELFELREALEVYAAGLAASNATPEDLAEVEELLRRAAAATEAGDAELITDINSRLHDRIVAMAGNSLLTAALEPVAGRLRWMTRRNEEWPQLLVEHRELYEAIASGDPERARTHALTHVRTNYRSTVRHLFGDAES
>NZ_CP013743.1|WP_058925950.1|7435032_7435995_+|prolyl-aminopeptidase
MPLYPETEPYDHGLLDVGDGNRVYWETCGNPRGKAALVLHGGPGSGSSPYYRRLFDPAAYRIVLLDQRGSGRSVPHASAYDTDMSVNTTAYLLADLELLRRHLGIERWLVWGVSFGSVLGLRYAQTHPGAVSEVVVTGVATGSNAEVTLLTRGVGRFFPEAFERFKAALPAGERDGNLAAACNRLLESPDPEVRARAARTWTDWETATVPAPPRSIPRFEDPEFRYGFARTVTHYWGNDHFLGEGNDEGVVLRDAPVLKDVPGTLVQGSLDFGNLLGISWRLHHAWPGSELVIVDDVGHSVGDPGMAEALVAATDRYARR
>NZ_CP013743.1|WP_058925949.1|7434301_7434994_+|uracil-DNA-glycosylase
MDSLVELDSRIAGCAACPRLVEWREEVGRTKRAAFRDWTYWARPVPGFGPADASLLIVGLAPAAHGGNRTGRMFTGDRSGDVLYRALYDVGLASRPTSVAVDDGLELLGVRITSPVHCAPPENKPTAAERDTCRSWLVQELRLLRPTLRAVVVLGAFGWQAALPAFAEAGWAVPRPRPVFAHGTRVPLDGLDLFGCFHVSQRNTFTGKLTPDMLRDVLRTAGEAAGLPVK
>NZ_CP013743.1|WP_058925948.1|7433698_7434226_-|RNA-binding-S4-domain-containing-protein
MAPQADEDGTAGPQNTVQEADAEKAVDPQVAAAIAAAEAAGPASGESVRVDSWIWAVRLIKTRSLGAAACKGGHVRVNGQNVKPSHSLRVGDEVRLRHEGRERIVIVKRLIRKRVGAPVAVQCYVDNSPPPPPREAVAPIGIRDRGTGRPTKRDRRELERLRGLLGGGAGRPDGR
>NZ_CP013743.1|WP_107416306.1|7443212_7443773_-|response-regulator-transcription-factor
MASAEGIEVVGEAGSGEEALALAARLRPDVVLMDLQLGDGMDGVAAIRELTASQSPPHVLVLTMFDTDADITRAIEAGATGYLLKAERPEELFTAVHSAARGRTALSAPVADRLLARMRSPHPVLSAREREILGQLARGLGNREIARALFISEATVKTHLGRIYGKLGVETRAGAVAVAKERRLLG
>NZ_CP013743.1|WP_079078182.1|7443838_7445164_-|sensor-histidine-kinase
MENTEAPPGGREAEGPGTGSGGSPDERRLLVVVHAAFLLLLGSSFARFLTRDQGGSRTAWVAGLFAVFALLYGLGHLLAPPPRAGTPPGARHLAWLASVSAVWAALLALAPSATWCAMPLLFAGLYALPPRIAVPLAGVLTALVVVCEVRAAEGPLNPNMVVAPIAVAAVATAVFVHLQRQGARQRALIDDLVRTRRDLAATERRAGVLAERQRLSAEIHDTLAQGLSSQRMLLQAAQRVWPTDPETARAHVREAADVTARSLAEARRFVHDLAPADLAGRSLPAALAALAERESGPGLTVGFHLVGDLPVPLPERTDAALLRIAQGALANVREHAAATRAALTLTCLDEQISLDVADNGRGFDPAPALPATTVASPTAAPGRTRGHGLPAMRIRARQSGGTLTVESAPGEGTVVTAAIPLAPAEAARADTAYGPTPEPAA
>NZ_CP013743.1|WP_058925959.1|7445330_7446104_+|class-I-SAM-dependent-methyltransferase
MPARNLTVNRAALGHRLGYALRHPDRVPRHLARAARDLWLSHRHRDHIDYYRAVMRSDTRDSPDAAVGSRTRERWLALGAMQFDYLVGHGLRPAHRMLEIGCGNLRGGWRFIRHLEPGHYYGIDISPDILFAAQDTIVEMGLEKRLPTLTPVRDLTFRFLPDAHFDVVHAHSVFSHSPLHVIEECLAHVGRVLAPGGWFDFTFDRTEGEEHHVLREDFYYRTRTLVHLAGKYGLRARFMEDWEALPHGQSKIRVTAG
>NZ_CP013743.1|WP_058925960.1|7446123_7447077_-|endonuclease
MLLGTWNLENLFRPGDPGGPPDEATYRTKLAALAAVVTELDPALLGVQEVGDPDALQDLLDLVGGDWHTALSKHEDGRHIRVGVISRAPLRVLADTNAFPPGLHPVQVNDSGTELSAAGRGFLAVEVTADGGPLRVAVAHLKSKLLEYPGNRFFPHDEGERARYGAYALYRRAAEAATLRALADELLDGDGRARDVAVLGDMNDEVQAATTQMLLGPPGSEIGTTGYDRPDQGDAERLWDVAPLIPPEQRYSRINSGRRELIDHILLSHRLVHRVTAAGTGLPGGGTPHLPSVGPDPTERRGKPGSDHAPVWARVGR
>NZ_CP013743.1|WP_058925961.1|7447566_7448256_+|DUF899-domain-containing-protein
MSLPEIVSRAQWRAARANLLVKEKAATRARDALNAERRRLPMVAVDREYVFEGGDGKATLDDLFEGRPQLIVHHFMFAPEWDAGCRCCSAFLDQIGHVAHLAARGTTFAVVSRAPYTKILPFKARMGWSLPWYSSSGGDFPHDFEATMERDGELVDRAGVSCFLRDGERICHTYSTYGRGLDGLGSTTSLLDLTALGRQEEWEEPKGRASALGTPVNSAPVRYHDEYED
>NZ_CP013743.1|WP_058928477.1|7448413_7448596_+|hypothetical-protein
MNGRMVLERFPAGGPRGSWPAEEFAHARRLEGLPAEVVMDLATDMFLVIVRGDTAADAVA
>NZ_CP013743.1|WP_058925962.1|7448602_7450552_-|ABC-transporter-ATP-binding-protein
MRSRKRAGAGEPGVSESERLLFGGPLRYDMGWNSHNDAFLELSLRAMVTRLPELLGASCRLAWQADRRAARAVVAAEVGRGVAQAVGLLAMNSVLGRLIARGAIEHRLRDAVPVLAVLGAVALVGALLRAASTWATGRLEPKVERVATELYLERAAAVELAAIEDHAFHKLLDTAQYGAGSARRMISYATRVVSALISLVAAASVLTVLHPVLLPLLATMTLPTAWGALTNARRRYESWHTWVQHARASRLVSGLLTEPEAAPEIRVHGVGPFLLRHYRAMAETAEAEQARLARLAARTGVIASAWTGVTTVATYATLTGLLLAGAMALSVAGTAVIAIRTGSSSLDNLVVAVNSLHEDALFVGDLQRLYVEAAERAIPVGGDALPEDPREIRFEHVSFSYPGDSARPALDDVTLSLPLGRIVALVGENGSGKTTLVKLLAGLYRPDSGRILWDDVDAATADRYQLAERVAMVAQDFKRWPFTARVNVAIGRSSAPLTEERMASAVAEAGAEGVVAGLPNGLDTLLARQFSGGHELSGGQWQRLGISRAAYRRGRILVVDEPTAALDARAELEVFDKIRALASAGQTVILITHRLASVRHADLVHVLDQGRLAESGTPEELLAGGGIYAELYSLQAEQFTAPVPAPEAG
>NZ_CP013743.1|WP_058925963.1|7451613_7452048_-|hypothetical-protein
MRAASGGQVLSLDTLVRLKRGLHGSSRPRRLPVPEGMTAPLGCDAVAVPARFGPLLMPRLPRVGCVYADEAHWWWLVPSDSDYALEWPAPALYAAGAVVPDAPAVPGLIHRPDGTLPYTPPIPLYLALCRVTGTTPTWSRPVIA
>NZ_CP013743.1|WP_058925964.1|7452044_7452704_-|ATP-binding-protein
MASVIPSAPLGTDAAAGHPHSLGAAPGADPTGVAAERRFRFELAAHPGSPAQARRMTRARLNGWAVCEDICDTAALVVTELVTNALVHTASSLIVCELHDGADLVRIAVRDEGCAPGAPHPSRARPEEEHGRGLLLIDSLCHAWGAHEHGPGLLVWAELPRQADEPWHDCGPCNDLGWGARPKPGQAGGSGDGEDAEAQHGTGAVGAAPAGRLREGGRE
>NZ_CP013743.1|WP_058925965.1|7452930_7453791_+|helix-turn-helix-domain-containing-protein
MSEPRSAPTVGQVVLGRRLLDLRERAGLKREEAAKVLRVAPATVRRMEMAEVGLKIPYLQLLLKSYGVSDEEAETFVQLAEEANKPGWWQRFHDILPGWFSMYVSLEGAASLIRSYDPHFVPGLLQTEDYARGVLKSGAIGQTRPEDIERHVALRIQRQELLTRTDAPRFWAVFDETALRRPVGGPEVMRAQIDKLLDATKLPHVTLQVAPFLSGPHPGTFGPFVLFRFAMSELPDMVYSEYLTGAVYLDARSEVATHLEVMDRMAAQAATAHRTKEILQDLRKEL

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Crispr_ID: NZ_CP013743_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_12

7827384-7827473

Orphan

Consensus_repeat	Method
AAGGGGCGCGGGGAACTGCGCGA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP013743_12

>merge|NZ_CP013743|12|7827384-7827473|CRISPRCasFinder
AAGGGGCGCGGGGAACTGCGCGAGCAACCCCCACTTCCCGCACCCGACATGCGTCCGCCACACCCCCAAGGGGCGCGGGGAACTGCGCGA

>NZ_CP013743|12|10|7827384-7827473|CRISPRCasFinder
AAGGGGCGCGGGGAACTGCGCGA	GCAACCCCCACTTCCCGCACCCGACATGCGTCCGCCACACCCCC
AAGGGGCGCGGGGAACTGCGCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_058926261.1\|7815610_7817848_+\|molybdopterin-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|239163
NZ_CP013743.1\|WP_058926263.1\|7819425_7820649_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP013743.1\|WP_058926270.1\|7828332_7828974_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367243
NZ_CP013743.1\|WP_058926273.1\|7831295_7831757_-\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|239534
NZ_CP013743.1\|WP_058926274.1\|7831865_7832342_+\|redox-sensitive-transcriptional-activator-SoxR	unknown	unknown	gnl\|CDD\|131005
NZ_CP013743.1\|WP_058926277.1\|7834352_7834955_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058926262.1\|7817986_7819402_+\|citrate:proton-symporter	unknown	unknown	gnl\|CDD\|225407
NZ_CP013743.1\|WP_058926265.1\|7822228_7823569_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226359
NZ_CP013743.1\|WP_058926268.1\|7826190_7827138_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP013743.1\|WP_058928505.1\|7829063_7830215_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NZ_CP013743.1\|WP_058926267.1\|7825085_7826165_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176240
NZ_CP013743.1\|WP_058926272.1\|7830649_7831273_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380061
NZ_CP013743.1\|WP_058926275.1\|7832352_7833420_-\|RNA-ligase-(ATP)	unknown	unknown	gnl\|CDD\|274075
NZ_CP013743.1\|WP_058926276.1\|7833512_7834244_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225785
NZ_CP013743.1\|WP_058926264.1\|7820705_7821296_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_079078195.1\|7821282_7822047_+\|class-F-sortase	unknown	unknown	gnl\|CDD\|320678
NZ_CP013743.1\|WP_058926260.1\|7814860_7815478_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380058
NZ_CP013743.1\|WP_058926271.1\|7830276_7830522_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377503
NZ_CP013743.1\|WP_058926269.1\|7827533_7828253_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP013743.1\|WP_058926266.1\|7823683_7825072_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143456

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_058926261.1\|7815610_7817848_+\|molybdopterin-oxidoreductase-family-protein	gnl\|CDD\|239163	cd02762, MopB_1, The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NZ_CP013743.1\|WP_058926263.1\|7819425_7820649_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.44948e-25
NZ_CP013743.1\|WP_058926273.1\|7831295_7831757_-\|MaoC-family-dehydratase	gnl\|CDD\|239534	cd03450, NodN, NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their legume hosts, a symbiotic process that requires production of Nod factors, which are signal molecules involved in root hair deformation and meristematic cell division. The nodulation gene products, including NodN, are involved in producing the Nod factors, however the role played by NodN is unclear.	2.14561e-91
NZ_CP013743.1\|WP_058926274.1\|7831865_7832342_+\|redox-sensitive-transcriptional-activator-SoxR	gnl\|CDD\|131005	TIGR01950, HTH-type_transcriptional_activator_SoxR_homolog, redox-sensitive transcriptional activator SoxR. SoxR is a MerR-family homodimeric transcription factor with a 2Fe-2S cluster in each monomer. The motif CIGCGCxxxxxC is conserved. Oxidation of the iron-sulfur cluster activates SoxR. The physiological role in E. coli is response to oxidative stress. It is activated by superoxide, singlet oxygen, nitric oxide (NO), and hydrogen peroxide. In E. coli, SoxR increases expression of transcription factor SoxS; different downstream targets may exist in other species. [Cellular processes, Detoxification, Regulatory functions, DNA interactions].	2.63154e-78
NZ_CP013743.1\|WP_058926262.1\|7817986_7819402_+\|citrate:proton-symporter	gnl\|CDD\|225407	COG2851, CitM, H+/citrate symporter [Energy production and conversion].	5.81784e-171
NZ_CP013743.1\|WP_058926265.1\|7822228_7823569_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226359	COG3839, MalK, ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism].	1.31503e-131
NZ_CP013743.1\|WP_058926268.1\|7826190_7827138_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	8.66867e-18
NZ_CP013743.1\|WP_058928505.1\|7829063_7830215_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	1.58379e-163
NZ_CP013743.1\|WP_058926272.1\|7830649_7831273_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	3.42246e-35
NZ_CP013743.1\|WP_058926275.1\|7832352_7833420_-\|RNA-ligase-(ATP)	gnl\|CDD\|274075	TIGR02306, hypothetical_protein_44RRORF209c, RNA ligase, DRB0094 family. The member of this family from Deinococcus radiodurans, a species that withstands and recovers from extensive radiation or dessication damage, is an apparent RNA ligase. It repairs RNA stand breaks in nicked DNA:RNA and RNA:RNA but not DNA:DNA duplexes. It has adenylyltransferase activity associated with the C-terminal domain. Related proteins also in this family are found in Streptomyces avermitilis MA-4680 and in bacteriophage 44RR2.8t. The phage example is unsurprising since one mechanism of host cell defense against phage is cleavage and inactivation of certain tRNA molecules. A fungal sequence from Neurospora crassa scores between trusted and noise cutofffs and may be similar in function.	3.95979e-157
NZ_CP013743.1\|WP_058926276.1\|7833512_7834244_-\|hypothetical-protein	gnl\|CDD\|225785	COG3246, COG3246, Uncharacterized conserved protein [Function unknown].	3.90698e-22
NZ_CP013743.1\|WP_058926267.1\|7825085_7826165_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176240	cd08279, Zn_ADH_class_III, Class III alcohol dehydrogenase. Glutathione-dependent formaldehyde dehydrogenases (FDHs, Class III ADH) are members of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. Class III ADH are also known as glutathione-dependent formaldehyde dehydrogenase (FDH), which convert aldehydes to corresponding carboxylic acid and alcohol. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of an beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding.	3.07855e-161
NZ_CP013743.1\|WP_058926266.1\|7823683_7825072_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143456	cd07138, ALDH_CddD_SSP0762, Rhodococcus ruber 6-oxolauric acid dehydrogenase-like. The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid, and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and other similar sequences, are included in this CD.	0
NZ_CP013743.1\|WP_079078195.1\|7821282_7822047_+\|class-F-sortase	gnl\|CDD\|320678	cd05829, Sortase_F, Sortase domain found in the class F family of sortases. Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.	1.77384e-50
NZ_CP013743.1\|WP_058926260.1\|7814860_7815478_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380058	pfam17928, TetR_C_22, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the TetR Transcriptional Repressor present in sco1712 proteins from Streptomyces coelicolo which act as a regulator of antibiotic production.	3.37716e-18
NZ_CP013743.1\|WP_058926271.1\|7830276_7830522_+\|hypothetical-protein	gnl\|CDD\|377503	pfam05360, YiaAB, yiaA/B two helix domain. This domain consists of two transmembrane helices and a conserved linking section.	2.20022e-16
NZ_CP013743.1\|WP_058926269.1\|7827533_7828253_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.30417e-13
NZ_CP013743.1\|WP_058926270.1\|7828332_7828974_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|367243	pfam02909, TetR_C, Tetracyclin repressor, C-terminal all-alpha domain.	6.65598e-15

>NZ_CP013743.1|WP_058926268.1|7826190_7827138_-|DMT-family-transporter
MMRTAPSRPRLLPAAAAATTVVLWASAFVSIRSAGAAYSPGALALGRLLSGCLVLGVFMVVRREGLPPRAAWRGILISGLLWFGFYSVVLNWGEQQVDAGTAALVVNIGPILIALLGARLLGDPMPPRLLAGMAVSFAGAVTVGLSMSGGGGSSVLGVVLCLLAAVGYAGGVVAQKPALGQASALQVTTFGCVVGAVMCLPFAGQLAGEAADAPLSATLNMVYLGVFPLALAFTTWAYALARTTASRMGATTYAVPALVVLMSWLVLGEVPGPLTLAGGALCLAGVAVSRSRARARAAAQETVPEPRPERAPDSV
>NZ_CP013743.1|WP_058926267.1|7825085_7826165_+|zinc-binding-dehydrogenase
MVRAAVLPEVGAPLQLTDIELPDPGPGRVRVRLAAAGVCHSDLSLSNGTMRVPVPAVLGHEGAGTVVSVGEGVADIAPGDPVVLNWAPSCGHCHACSLGEVWLCANALNGAADVYARSAAGVDLHPGLNVAAFAEETVVPASCLLPLPEGVPLTDAALLGCAVLTGYGAVHHSAKVRPGETVAVFGVGGVGLAALQAARIAGAARIIAVDVSLEKEELARNAGATDYVVASENTAREIRGLTGKQGVDVAVECVGRATTIRTAWDSTRRGGRTTVVGIGGKDQQVTFNALEIFHWGRTLSGCVYGNSDPAQDLPVLADHIRSGRLDLGALVTERIALDGIPAAFENMLAGKGGRALIVF
>NZ_CP013743.1|WP_058926266.1|7823683_7825072_+|aldehyde-dehydrogenase-family-protein
MKAHDGMYIDGAWRPAAGTDVIEVVNPVDEQVIGHVPAGTAADVDAAVRAARAALPAWSATPPTERAARLTALRDALLARKDEIAETVTAELGAPLQFSQNVHAAVPIAVAGSYAELAATYAFEEKAGNSTVYLEPVGVVGAITPWNYPLHQVVAKVAPALAAGCTIILKPAEDTPLVAQLFAEAVHEAGVPAGVFNLVTGLGPVAGQALAEHPDVDLVSFTGSTAVGRRIGATAGAAVKRVALELGGKSANVILPSADLAKAVNVGVANVMSNSGQTCSAWTRMLVHRERYEEAVELAAAAAAKYGPRIGPVVNAKQRARVRGYIDKGVAEGARLVAGGTEPPHEQGYFVSPTVFADVTPDMTIAQEEIFGPVLAILPYEDEEDALRIANGTVYGLAGAVWAGDEAEAVAFARRMDTGQVDINGGRFNPLAPFGGYKQSGVGRELGAHGLAEYLQTKSLQF
>NZ_CP013743.1|WP_058926265.1|7822228_7823569_+|ABC-transporter-ATP-binding-protein
MTRAISLQDVSKTYTRGVRVVDRLSLHIEPGEFLVLLGPSGCGKSTVLRMIAGLEEITEGTLLLDGEEANDLVPSERNMAMVFQNFALYPNMTSRGNIGFPLRVENPGEDPRPRVDATARMLGIEDLLDRFPAQLSGGERQRVAMGRAIARHPSAFLMDEPLSNLDAKLRNHLRAEISKLTRELGVTTVYVTHDQAEAMSLGDRVAVLRGGVLQQVGTPRSVYALPRNVFVAAFIGTPRINLLRGLVRAPLDGAMTISLGKQFLRLPEPLSRDHQLLRVQQGREVIVGLRSEAVRIAKHSSARPGEVPLTGLVEHVEFQGHEILVHFDTGSQPAVVPDLEAPRPASRPSRRRRREGGVTVLGRLRERAEAMRAGPVVVLDEPAGPDPAAPSEPRLPGDLVVRTTPDIDLRRGLQVPLLVDLAHLFVFDQHGERICPAPARLPDLDE
>NZ_CP013743.1|WP_079078195.1|7821282_7822047_+|class-F-sortase
MAGRNSRTPGPGARRPSAHRGRARRPRPWYRTRAYRLSRTLVLGFLLVVGAVRCSQDDGPPTTTAAPEPAPARSQSPAPRADDARPAPPRTAPPRTAPPPRPLSRSRATRVVIPYIGVDAPVFGLGLDRDHRLTAPPEDDGHRVGWYEGGPSPGEQGTVVVVGHLDTRTGPAVFAGLGELGPGHLVELRRADGHSAFYTVDKVRTYEKAHFPNGEVYGARGRPELRLITCGGAYDRRTGYAGNTVVFAHLTRTR
>NZ_CP013743.1|WP_058926264.1|7820705_7821296_+|hypothetical-protein
MPTMPLQRRAGARTAALAALTIAGSALLGSPALAAPTPVPGDNGDVKIHKVGASVPEKDNQPHVCRFYLDAFNFDAAEKVTWTIAGQPPTAGAGTKTGTLTTDATGAAHTNPVTLSNGHYKLTWTTSLGHGAGKMKVFWVDCATSTAAPNGGPPAGGGGLARDAAINPVAGAAAVGLAAVGGAVYFRLRRRPHGRA
>NZ_CP013743.1|WP_058926263.1|7819425_7820649_+|MFS-transporter
MRPGGNRGWLLRLVIAFSFAQGAVSMARPAVSYRALALGADERAVGVIAGVYALLPLFAAVPLGRRTDHGRCAPLLPVGVALIAGGCALSGLAGSLWAMAVWSGVMGLGHLCFVIGAQSLVARQSAPHEQDRNFGHFTIGASLGQLVGPIAAGALIGGPDMAGTSALALLVAGAGAAAAFTSLWRIEDRTAGNSPAAQVDRVAVGSILRARGVPAGMLVSLSVLSATDILTAYLPVVGEHRAIAPSVIGVLLSLRAGATIACRLVLTPLLRLLGRPALLTVTCLLAAVLCAGVALPVPVWALGLMLTVLGFCLGVGQPLSMTTVVQAAPDGARSTALALRLTGNRLGQVAAPATAGLVAGLVGAAAPFVMLGGLLLLSAGVALRSPAPDGGKVTGRRATLPQSARRM
>NZ_CP013743.1|WP_058926262.1|7817986_7819402_+|citrate:proton-symporter
MLTLLGFAMIATFLVLIMLKKMSPIAALVLIPALFCVFVGKGAKLGDYVIDGVTSLAPTAAMLMFAIVYFGVMIDVGLFDPIVRGILKFCKADPLRIVVGTAVLAAIVSLDGDGSTTFMITVSAMYPLYKRLKMSLVVMTGVAAMANGVMNTLPWGGPTARAATALKLDASDIFVPMIPALAMGLLFVFALAYVLGRRERKRLGVLTLDEVLVEEPAEQETVLVGAGAGNGAKNGNGPKSGGGSGAGAALPDAPEDEGFQGLDPDRPTLRPKLYWFNALLTVVLLTAMIMEWLPIPVLFLLGAALALTVNYPHMPDQKARIAAHAENVLNVSGMVFAAAVFTGVLQGTGMVDHMAEWLVRNIPDGMGPHMAFVTGVLSIPLTYFMSNDGFYFGILPVLAEAGQAHGVSSLEIARASLIGQPLHMSSPLVPAVYVLVGMAKVEFGDHTRFVVKWAALTSLVVLGAGILFGII
>NZ_CP013743.1|WP_058926261.1|7815610_7817848_+|molybdopterin-oxidoreductase-family-protein
MSRTALRICPLCEATCGLTLTIDGTRVTGARGDRDDVFSKGFICPKGASFGAVDGDPDRLRTPLVRRDGELREATWEEAFDAVAAGLRGVVDAHGPHAVGVVLGNPNVHTVAGGLYPPVLLAGLGTRSIFTASTVDQMPKHVSSGLLFGDANAIPVPDLDRTDHLLLIGANPLESNGSLCTAPDFPGKLKALKARGGTLVVIDPRRTRTAKLADLHIPIRPGTDALLLAAMAYVLFDEGLVDLGELAPHVEGVDELRAELGDFTPEAVAEACDVEPALIRTLARDLAAAPTAAVYGRIGSCTVPYGTLGSWLVDVLNILTGNLDRPGGSLFPQAATDRTPRPAGPSHGFALGRWHSRVSKHPEAKGELPLSALAEEIDTATEEGESVRALIAVAANPVLSAPDGDRLDKALAGLDFMVSVDPYLNETSRHATVVLPPPPPSQSPHHDFAFNTLAVRNQVRYTRPAVPLEPGRMAETEILARLILAATGMHGADPSAVDDLVVGQTLGKAVEEAHSPVHGRDPKELAALLTGENGPERRLDMMLRLGPYGDGFGVRPDGLSLQKLLAHPHGIDLGPLAPRLPQPLKTRSGKVELLARPIADDLPRLRRALGELPDGLVLVGRRHLRSNNSWMHNVPALTGGSNRCTLHLHPEDAERLGVRDGDPVRVKGAGGEVTAPAEVTDAVRRGVVSLPHGWGHDRPGTRMSHAASDPGVNVNQLLDGSLLDPLSGNAVLNGVPVEVAAALPA
>NZ_CP013743.1|WP_058926260.1|7814860_7815478_+|TetR/AcrR-family-transcriptional-regulator
MKPVPHATSLRRAPVQRRSAERLTRILDACADLLDEVGYDALSTRAVALRAGVPIGSVYRFFGNKRQMADALAQRNLERFTEHVTERLKDSGEGGWRIAMDAVLDEYLSMKRTAPGFSLVDFGNQIPVGARDAGPNHRVADRLSDLLSGYLDREPDEDLRRTFLIAVETADTLVHLAFRMAPEGDAKIIEEAREMLRAYLARVLD
>NZ_CP013743.1|WP_058926269.1|7827533_7828253_-|winged-helix-turn-helix-transcriptional-regulator
MTTKDPQAPRLARLAGLIADETRAACLLALLDGRAWTAGELARHAGVAASTLSEHLGKLVAGGLLSEERQGRHRYVRLADARVAQLVEELAAHAGAGPGDVVGRPRGLRAVSAGSAMARGRTCYDHLAGRLGIAVTDALALRGLLRVDTGFALTDAGVEWFGAAGIALRRSGRRPLVRACLDWTERRPHLAGVAGAALCGHALEAGWCVRIGSERAVKVTAVGERALHELLGIEEGALR
>NZ_CP013743.1|WP_058926270.1|7828332_7828974_-|TetR/AcrR-family-transcriptional-regulator
MARPRKPLLSTDRIVEAARALVDTEGLAAVSTRRLAAELGVSGPSLYNHFRTKDEILEAVADSVSAQVDLSMFDDGRDWRTALHDWAVSYRAALRDHPNIVPVLATGPGRRPAGLRLADAVYGAMVRAGWPAAQATSIGALMRYFIMGSALGSFAGGFVDDATAYDPADYPHLGQAHLLAEHQEKIDERAFETGLTALLDGLAQQYEQVRRRV
>NZ_CP013743.1|WP_058928505.1|7829063_7830215_+|acyl-CoA-dehydrogenase
MNLGLSEEQEAVRRLARDFVAREITPNVVAWDRAEEVDRAIVKKLGEVGFLGLTIDEEYGGSGGDHLAYCLVTEELGRGDSSVRGIVSVSLGLVAKTIAAWGSEEQKRRWLPGLTSGDHVGCFGLTEPGTGSDAGNLTTRAVRDGDDYVVSGTKMFITNGTWADVVLLFARSTDAPGHKGVSAFLVPTDTPGLTRRTIHGKLGLRGQATAELVLEDVRVPASAMVGEEGKGFSVAMSALAKGRMSVAAGCVGIAQAALDAAVGYAGEREQFGRPIAHHQLVQELISDIAVDVDAARLLTWRVADLIDRGLPFAVESSKAKLFASEAAVRAANNALQVFGGYGYIDEYPAGKLLRDARVMTLYEGTSQIQKLLIGRALTGVSAF
>NZ_CP013743.1|WP_058926271.1|7830276_7830522_+|hypothetical-protein
MSETSGKQQNTAAFYGQAVASFAVAMAATAIGIFKLNADAWVRAFLGIAVLYLVTSAFTLAKVIRDRQEAVERSYHPFEKL
>NZ_CP013743.1|WP_058926272.1|7830649_7831273_+|TetR/AcrR-family-transcriptional-regulator
MSTAEETAGGEVAPWGEVTPDAARRLLMAAVEAFAERGYHATTTRDIAGRAGMSPAALYIHYKTKEELLHRISRIGHEKAVDILRTAARGEGTPAERLADAVSSFVRWHAGGRTTARVVQYELDSLGPDARAEILALRRQCDAEVRGIIEDGIAVGDFEVLDVKGTTLAVLSLCIDVARWFNVHGPWTPDEVGALYADLVLRMVGVK
>NZ_CP013743.1|WP_058926273.1|7831295_7831757_-|MaoC-family-dehydratase
MAEPRIFTSADELKAAVGEQLGYTDWLEIDQKRIDLFAEATGDHQWIHVDPEKAASGPFGTTIAHGYLTLSLLPLFGPQLIQVEGVKMGVNYGTNKVRFPAPVPVGSRLRATARISGVEDVPGGVQVAVAYSVEREGGDKPVCVAESVARFYL
>NZ_CP013743.1|WP_058926274.1|7831865_7832342_+|redox-sensitive-transcriptional-activator-SoxR
MPQIPETIHELTVGQLAARSGAAVSALHFYESKGLISSRRTAGNQRRYTRDTLRRVAFVRAAQRVGIPLATIREALSELPEERTPTREDWARLSENWRSELDERIRQLNRLRDHLTDCIGCGCLSLDSCVLSNPDDAFGERRSGSRLMVERRSAAAGE
>NZ_CP013743.1|WP_058926275.1|7832352_7833420_-|RNA-ligase-(ATP)
MSTLRVTAEVLTVHEHPDADALELAQVGLYRAVVAKGAYRTGDAAVYIPEQAVLPAGLIEELGLTGRLAGTKADRVKAVRLRGELSQGIVCRPKALADVDLTRAAAEGTDFAEALGITKWVPPIPPTMNGDVESAPELLPWVDIENIQRFPDVFAPGEAVVLTEKLHGSACLLTYAADEGRVYVSSKGFGAKSLALKEDPRNLYWRAVHGHGVAEVAKRLAGRLGARRVGIFGEVYGAGVQDLTYGADGRRESLGYAVFDVCAEVDGAVRWLDAAELLDGELPLVPRLYEGPYDVERVLEIASGRETVSGRGLHLREGVVIRTAVERHSPVTGGRAIAKAVSPAYLTRKGGTEYE
>NZ_CP013743.1|WP_058926276.1|7833512_7834244_-|hypothetical-protein
MVQVCLNGTRGSADGAMIPLTPQALGESAAEAVAAGATDVHVHPKTPCGRDALSPRVLGPVLEAIRARVRVPVGVTTGAWAEPDPAARLARVRSWADLPAPPDHASVNWHEEGAEEIAAALIGLGVGVEAGIWSGTDGAARFAVSPLKGRVLRVLAEVTDTSAGTAEDSARALLAGLGPALGRPVLLHGEDGGAWPVLRLAGRLGLATRIGLEDTLVLPDGEPALSNAELVAEGLRQYRAARR
>NZ_CP013743.1|WP_058926277.1|7834352_7834955_-|hypothetical-protein
MAGFRSLARQVRDPRCDLALRRYSLRKCLERFAPYGHRATWDHLCSRAGFGPEDRSPDPARLVAALEELEEARSVWLAYEVEFAERRKKEKHDGLRRPGSVDDWHRLTWGGFGVAWCDDPRVHPREPLAEVLRRLISALEREPGAECPVCGGERLVWTYDLDHEPSSGPVCSNCGILVPRPVLKPEALADARRGRLLVSA

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Crispr_ID: NZ_CP013743_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013743_13

9263814-9263923

Orphan

Consensus_repeat	Method
CTTCGTCCCCGGCGGGTGCCGTCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP013743_13

>merge|NZ_CP013743|13|9263814-9263923|CRISPRCasFinder
CTTCGTCCCCGGCGGGTGCCGTCGCCTCCGCGTGATGACGCTGCCGTCGGGCACGGCGGTGCGGCCTCGCCATCGCTCGCGCGTCTTCGCCCCCGGCGGGTGCCGTCGCC

>NZ_CP013743|13|11|9263814-9263923|CRISPRCasFinder
CTTCGTCCCCGGCGGGTGCCGTCGCC	TCCGCGTGATGACGCTGCCGTCGGGCACGGCGGTGCGGCCTCGCCATCGCTCGCGCGT
CTTCGCCCCCGGCGGGTGCCGTCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013743.1\|WP_058927393.1\|9269360_9270206_+\|lysozyme	unknown	unknown	gnl\|CDD\|119374
NZ_CP013743.1\|WP_058927394.1\|9270360_9270570_-\|DUF4177-domain-containing-protein	unknown	unknown	gnl\|CDD\|379366
NZ_CP013743.1\|WP_079078258.1\|9258547_9259897_+\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|235917
NZ_CP013743.1\|WP_058927391.1\|9266490_9267117_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239489
NZ_CP013743.1\|WP_107416324.1\|9265234_9266494_+\|diacylglycerol-kinase	unknown	unknown	gnl\|CDD\|224513
NZ_CP013743.1\|WP_058927389.1\|9261528_9262095_-\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|213983
NZ_CP013743.1\|WP_058927386.1\|9259980_9260421_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP013743.1\|WP_058927384.1\|9254810_9255389_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NZ_CP013743.1\|WP_058927383.1\|9254243_9254738_-\|FBP-domain-containing-protein	unknown	unknown	gnl\|CDD\|379860
NZ_CP013743.1\|WP_107416325.1\|9268376_9269276_+\|sugar-kinase	unknown	unknown	gnl\|CDD\|238920
NZ_CP013743.1\|WP_058927395.1\|9270701_9271448_+\|DUF4097-family-beta-strand-repeat-protein	unknown	unknown	gnl\|CDD\|372574
NZ_CP013743.1\|WP_058927385.1\|9255405_9256626_+\|lipase	unknown	unknown	gnl\|CDD\|238881
NZ_CP013743.1\|WP_107416216.1\|9256708_9258265_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NZ_CP013743.1\|WP_058927388.1\|9260918_9261446_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058927396.1\|9271496_9273563_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP013743.1\|WP_058927390.1\|9264048_9264921_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_107416323.1\|9262273_9263470_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|349921
NZ_CP013743.1\|WP_058927392.1\|9267344_9268259_+\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP013743.1\|WP_058927397.1\|9274521_9274839_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013743.1\|WP_058927387.1\|9260484_9260721_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP013743.1\|WP_058927393.1\|9269360_9270206_+\|lysozyme	gnl\|CDD\|119374	cd06412, GH25_CH-type, CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme (acetylmuramidase) and diacetylmuramidase activity. The first member of this family to be described was a muramidase from the fungus Chalaropsis. However, a majority of the CH-type lysozymes are found in bacteriophages and Gram-positive bacteria such as Streptomyces and Clostridium. CH-type lysozymes have a single glycosyl hydrolase family 25 (GH25) domain with an unusual beta/alpha-barrel fold in which the last strand of the barrel is antiparallel to strands beta7 and beta1. Most CH-type lysozymes appear to lack the cell wall-binding domain found in other GH25 muramidases.	2.44542e-110
NZ_CP013743.1\|WP_079078258.1\|9258547_9259897_+\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|235917	PRK07046, PRK07046, aminotransferase; Validated.	0
NZ_CP013743.1\|WP_058927391.1\|9266490_9267117_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|239489	cd03395, PAP2_like_4, PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	2.6509e-24
NZ_CP013743.1\|WP_107416324.1\|9265234_9266494_+\|diacylglycerol-kinase	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	3.09127e-34
NZ_CP013743.1\|WP_058927389.1\|9261528_9262095_-\|hemerythrin-domain-containing-protein	gnl\|CDD\|213983	cd12108, Hr-like, Hemerythrin-like domain. Hemerythrin (Hr) like domains have the same four alpha helix bundle and a similar, but slightly different active site structure than hemerythrin. They are non-heme diiron binding proteins mainly found in bacteria and eukaryotes. Like Hr, they may be involved in oxygen transport or like human FBXL5 (F-box and leucine-rich repeat protein 5), a member of this group, play a role in cellular iron homeostasis.	3.60221e-14
NZ_CP013743.1\|WP_058927383.1\|9254243_9254738_-\|FBP-domain-containing-protein	gnl\|CDD\|379860	pfam16571, FBP_C, FBP C-terminal treble-clef zinc-finger. FBP_C is a family from the C terminal end of fibronectin-binding proteins. It forms an extended four-cysteine zinc-finger with a unique structural fold. Fibronectin-binding proteins bind to elongation factor G - EF-G, which is mediated by the zinc-finger binding to the C-terminus of EF-G. FBPs release ribosomes by competing with them for EF-G.	1.46613e-83
NZ_CP013743.1\|WP_107416325.1\|9268376_9269276_+\|sugar-kinase	gnl\|CDD\|238920	cd01945, ribokinase_group_B, Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time. .	2.2605e-55
NZ_CP013743.1\|WP_058927395.1\|9270701_9271448_+\|DUF4097-family-beta-strand-repeat-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	5.34657e-07
NZ_CP013743.1\|WP_058927385.1\|9255405_9256626_+\|lipase	gnl\|CDD\|238881	cd01844, SGNH_hydrolase_like_6, SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	4.8587e-66
NZ_CP013743.1\|WP_107416216.1\|9256708_9258265_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	1.44153e-07
NZ_CP013743.1\|WP_058927384.1\|9254810_9255389_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	2.20166e-18
NZ_CP013743.1\|WP_058927396.1\|9271496_9273563_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.52734e-45
NZ_CP013743.1\|WP_058927394.1\|9270360_9270570_-\|DUF4177-domain-containing-protein	gnl\|CDD\|379366	pfam13783, DUF4177, Domain of unknown function (DUF4177).	1.22703e-16
NZ_CP013743.1\|WP_107416323.1\|9262273_9263470_+\|amidohydrolase	gnl\|CDD\|349921	cd05672, M20_ACY1L2-like, M20 Peptidase aminoacylase 1-like protein 2-like, amidohydrolase subfamily. Peptidase M20 family, aminoacylase 1-like protein 2 (ACY1L2; amidohydrolase)-like subfamily. This group contains many uncharacterized proteins predicted as amidohydrolases, including gene products of abgA and abgB that catalyze the cleavage of p-aminobenzoyl-glutamate, a folate catabolite in Escherichia coli, to p-aminobenzoate and glutamate. p-Aminobenzoyl-glutamate utilization is catalyzed by the abg region gene product, AbgT. This subfamily includes Staphylococcus aureus antibiotic resistance factor HmrA that has been shown to participate in methicillin resistance mechanisms in vivo in the presence of beta-lactams. Aminoacylase 1 (ACY1) proteins are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	4.98621e-123
NZ_CP013743.1\|WP_058927392.1\|9267344_9268259_+\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	1.13326e-11
NZ_CP013743.1\|WP_058927386.1\|9259980_9260421_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	3.758e-25

>NZ_CP013743.1|WP_107416323.1|9262273_9263470_+|amidohydrolase
MGHAVDEAVGRVAGEVAVRADRLWETARTLHGDPEYAFAEHRAAELLSAELEREGFTVERDLAGLPTAFAARSGTPRRPAVALLLEYDALPGLGHACGHNLIAAAGLGAALAARAVLGDGDGTVWAVGTPAEEGGGGKVIETDAGVFDDLDAALMFHPGVHDWRWAPLTAQAQYRVGFHGRAAHPTGNPTEGIDALAALIQLFNTLAVVERRLPQGSHVQGIITDGGRATNIVPEYAEGLFGLRAATTAGLEDLAGELLTCAHGVARATDTTVTVERATPRYEHFRDCGVLSGRFAHHLSRAGIDLTPPQPGVFLGSSDIGNVSGRVPAIHPFVAVMGEDGSDHTPEFAAAAASDRGRRVMLAATEALACTAVELLLSPDLRDRAWSEHERHTVAPVG
>NZ_CP013743.1|WP_058927389.1|9261528_9262095_-|hemerythrin-domain-containing-protein
MGHGGNVIDELMTDHREVEEIFGRIEALPTGHKDRKVYADQATMELIRHSVAEEEYLYPAVREHVAGGDAIADKEIEDHSEAEQLMKDLESCEADHGEFDRLIGKLMTEVRSHIADEEQNLFPKLRAACSPEALDKLGDKVRQAKKTAPTRPHPSAPDTPPANKLLAPGAGMVDRMRDALSGRGKLDH
>NZ_CP013743.1|WP_058927388.1|9260918_9261446_+|hypothetical-protein
MLTDLSPLIAATAEWLTRAYPASGGALASALCEVQARQAVTVAASLRYPTPTDAALVGIVGPGGSGRLDWITGADAGAHSGDDAHAWRTWVDEVVASWAAALLTDPELSRLAVTALAEGGHDTGAPVRFRRLLAPDATDRRAAALLRHPDLLAPVASLHQDRLMDLLKPGRALIA
>NZ_CP013743.1|WP_058927387.1|9260484_9260721_+|hypothetical-protein
MTSSTETGGVTGTPNKDYNLIWYVEACLSNALRLESYIQDAEREKDGEVADLFRKAQADSRKGAELGKNLLRARLSGG
>NZ_CP013743.1|WP_058927386.1|9259980_9260421_+|Lrp/AsnC-family-transcriptional-regulator
MDEIDRAILRELQTDGRIAYADLGPKVGLSASAARQRLQRLLDTKTVQVVGVTDPMAMGGQAMALLGIAVDGDPRAVADELARREEVVYAVLTSGGFDLFAEVVAPGPRELLDFVNDVVRPVEGVRQIQSFPYFGIHTHRFLWDVG
>NZ_CP013743.1|WP_079078258.1|9258547_9259897_+|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme
MDRSRLQDLLARETAEAVRRCPRSKDAYGRADHLFGRVPMTWMNKTAGSFPRYLAAARGARVTDIDGHEYIDFCLGDTGAMTGHSPAAVADAVQHRFTDLGGATAMLPTEDAEWVGAELTRRFGLARWSFSLTATDANRWAIRLARAVTGRPKILFNSYSYHGSVDESLIVVGPDGRGEARPGNVGAPCDVTLTSRVAEFNDLEQLERELAHGDVAAVLMEPALTNIGIVLPEPGYLEGVRELTRRHGTLLINDETHTFSAGPGGCTAAWGLDPDLLTIGKAIGGGIPAGAYGLSAELADRLLGRSDLDLIDMGGVGGTLAGNALSVAAMRATLEHVLTDDAFAHMSKLSERFEAGVRAGIDAHGLPWTVSRLGARTEYRFASPAPRTGTESAAAADAVLEDFLHLYLANRGILLTPFHNMALMCPDTTEQDVDTHTEHFAAALDELVP
>NZ_CP013743.1|WP_107416216.1|9256708_9258265_+|helix-turn-helix-domain-containing-protein
MHEEKGDMTGPTDDARPARTTGAADASWARELLDLMRPGGRDDVHRVVAWLARTVRGTACLHDGDGTLLAGTPVPLDPDLVADITAGRIASAAWGDPGRHLRLVGVELPHPGTAGVLTVSRTTPFDPRASDVVTHTAQVLALLLRARETTRAARRLRRATSDLRLAILQLLMVEDTVSARRVAAGLWPGLLDTDTACVYVLEGDVGERDHIAEECLDATRERALVVRCPAMDAHVIVLAPRDAAADALRSLTARRPGLLLGGSAPHTLARTATAYGQAVSALAVARFRPDKQAVYAERTHPERLMDPSVLRAWTASLLEPLDTLAHHTRAELLATSRLGLEFTAVSAAKVLGVSRNTVRARMERVEALLGADFSDLTARAVVHLALNTQVGLADDDRRPDRAEADRARLGDLLAGPALRTWAHDLLTRLEADARDLRRTLRTWIAAGANAERAAECLGMHAQTVRDHVRSAECVLERQLLSGGSDLYEVVLAHLALGDLDEPPLHGTKRGHSGSPVHG
>NZ_CP013743.1|WP_058927385.1|9255405_9256626_+|lipase
MDTEHDWITTPVTAELLRGAIDVEHTERGLLPHRLPAWARAQYDDGQLAMAESQPSGVRLVFRTRATAVELDALPLKRAYTGAPARPDGLYDLLVDGRPAGQASVAGGDTVTIDMSTGGTELRSGEPGTLRFTDLPDRLKDIEIWLPHNETTRLVALRTNAPVEPAPDHGRKVWLHHGSSISHGSDAASPTTTWPALAASLAGVELINLGLAGSALLDPFTARTLRDTPADLISVKLGINVVNADVMRLRAFTPAVHGFLDTIREGHPTTPLLVVSPILCPIHEDTPGPTAWDMSALSAGRLRFQAAGDPAERDSGKLTLTVIREELARIVEQRAADDPHLFHLDGRSLYGEADHAELPLPDDLHPDAAAHRRIGERFADLVFAEDGAFGKSGSFGKSGSLGKSGS
>NZ_CP013743.1|WP_058927384.1|9254810_9255389_+|TetR/AcrR-family-transcriptional-regulator
MGRAGLTTERVVRAGAELADEVGFEQVTVSEVARRFDVKVASLYSHVRNSQDLKTRIALFALEELADRAADAVAGRAGKDALVAFANAYRDYGREHPGRATAARFPLDSETAAASAGVRHARMTRAILRGYDLAEPEQTHAVRLLGSVFHGYSSLETAGGFSHSAPDSEESWTRVLDALDVLLRNWPATPTP
>NZ_CP013743.1|WP_058927383.1|9254243_9254738_-|FBP-domain-containing-protein
MEPLTEQEIRAAFVNCSKGEAKRLHVPRDLADRPWEDLDYLGWRDPQAPDRAYLAAPLDARPVAVVLRTSSAGSWQARRSMCSICLTVHSGGVSLMVAPKAGKAGQQGNSVGAYLCDDLACSLYVRGRKDAGAGARMHETITLEEKIRRTVANLAAFVAKVRTA
>NZ_CP013743.1|WP_058927390.1|9264048_9264921_-|hypothetical-protein
MVTQAARAMWERFEPVHDLVYFAPEARRAADGLGMRGFWMGYFALRAAPLGPVSAPVVTACFYVFHPNRVARALPDAWRYAAPGDVLDARAQAMDAAMTRLLGTDVVSSAWMTEAADLAWRAAEAADTAGRPLAAANQALDRPRRPHTRLWQALTTLREHRGDGHVATLVGHGVAPVEAMVLKAASGESDAALLREGRKWDPADWRRAEAQLRERGWLDEAGALTPAGVTGRAAIEAQTDAVAEAPWKALGQDGTARLAALLDPLTTTVATSGLLPHGNPVGVTRAGAGG
>NZ_CP013743.1|WP_107416324.1|9265234_9266494_+|diacylglycerol-kinase
MLAGAGQWLILLLGLAGLALAGAGLWWALAHRGLARFFGALLAIGAPIGVLVLYAVSGLWVVAVAAVAAWTTAVACARSALRRLRSPHGMRHRTARPFRRAVFIMNPRSGGGKVGQFGLVERAEALGARVILLDLDTAPDPAALAREAVSEGADLLGAAGGDGTQALVASVAAEHGLPFVVVAAGTRNHFAMDLGLDRDDPSKSLDALTDGVELRVDLGEVGGLPFVNTASFGTYAQIVQSPEYRDAKAATALEQLPDLLTGDAAAPLTARTDDEVVEAPQAVLVSNNPYARADPLGVGRRPRLDAGSLGVIAVRVESAARAAELALLGERASGITSLTSRRVVIESDDELIPVAVDGEALTLPSPVVCRVRPAALRVRVPRHRPGAPYIAPSVDWRRVVRLAFDRTPDPREKEPGAQR
>NZ_CP013743.1|WP_058927391.1|9266490_9267117_+|phosphatase-PAP2-family-protein
MTDCPPREQRVPRGLLHDLAALDQALYEAVTVTSTPTLDVALRRLSAAADHSKISFAVAGALALWPGSSRRAAALGVAAIGVASATANLLGKRLVRRPRPHRAEDSPFPGRHVPMPESASFPSGHTASAVAFAATVGTAFPAATVPLGLLACAVGYSRVHTGVHYPGDVIAGAVLGTGAASAVLTAARWDGLSTIRPSALAPFKASRK
>NZ_CP013743.1|WP_058927392.1|9267344_9268259_+|peptidoglycan-binding-protein
MSEQAGPGCPECGEPRAADGTPTCSCTLRAADVRSETRTVEAAAAEDFDPVRIRPYVEIDVVADHGPADGPGADGTHPHPGLPGEFDDLLTAGDEPTEPLPPSPGDASPARRRRSRALLVTGVGAAAAVLVTGGVVGGIFWYDSPARKDSVADGVRAGLPDQRPSASGPASGRPSATASSARPSTTPSSSPSATASDGPATPTGSGTPSATPTATATATGAPAPTESGGRPPVLRLGDKGPEVVELQLRLRQVGYYDGPADGTFDSDVENAVRGYQFTRVILQDEPGVYGTATRASLESETKEP
>NZ_CP013743.1|WP_107416325.1|9268376_9269276_+|sugar-kinase
MGGAGGERRPAGLFVGLCTLDVIQLVDHAPGPDEKVTARQQEVAAGGPATNAAVTFHHLGGSATLLTAVGTHPLGAGVAADLRRLGVTVSDLAADSPEPPAVSSVLVTASTGDRAVASTNAAGHRLAPPDDLDALLVGCDLVEFDGHHMELAVATARRARETGRTTLFDGGSWKEGTPALLSSIDVAVCSSDFRPPGARTPADTLRFMRERGVAWAAVSGGAEPLVWEGPDGGGTVDVPRVRVVDTLGAGDVLHGALAHQLALRGPITAAGFVEALRAAAATAARACASFGTRAWLRDG
>NZ_CP013743.1|WP_058927393.1|9269360_9270206_+|lysozyme
MDGMRRSISAQHGRARRRLVASLTGLLALSSALTATPASAESIPERGTAYMGMGIMAHDGIAGGPDGSPPTTRAVHTEGVDVSSHQREVAWSTLWSNGVTWAYTKATEGTSYRNPYFDQQYGGAHDTGMIRGAYHFATPDSGSGTAQADYFVDHGGGWSGDGRTLPGALDIEWNPYGDSCYGKSKSGMVSWIRDFLNRYRSRTGRDAVVYTSTSWWSSCTGDYTGFGSNPLWVARYASTVGELPAGWSSYTMWQYTSSGQTVGDHDKFNGSADKLRQFADD
>NZ_CP013743.1|WP_058927394.1|9270360_9270570_-|DUF4177-domain-containing-protein
MSQAYEYKVVTFRESLIGDALDSDKLEKTLNKQAEDGWQLKAITSADVKGRIGPGAVEGLLLTFERPRV
>NZ_CP013743.1|WP_058927395.1|9270701_9271448_+|DUF4097-family-beta-strand-repeat-protein
MKATTTRRVLSLALTLTVLPVAAACGGHGDAASPALATDVPGGRLVVTTDNGLRLRPTDGHRVTVDDRVHAEWSHRGRTWTLDLSCRDAKGTDGSCPRMPAVRVPDGLSVTVSARNAGIDAAGVAAALDLTTVNGDMTVTRSGRADAPVRLATRNGSVRATGLDAARVRAATTNGDVVLACATAPSSVTATTTNGSVDVTVPHDAPAYRVTADTDNGRATTNVPASKGSRGPDMTLTTVNGDVEARLG
>NZ_CP013743.1|WP_058927396.1|9271496_9273563_-|SpoIIE-family-protein-phosphatase
MTAESFPPEGDAYGLDTPPPTRLLDVLSVAATVVDADGRIVFWTPQAEELFGYSAQEALGKYAARLFIHPEHLKAVVRLFTEVLETGRSWAGAFPIRHKDGSTRLMEFRNMRLQDDLGDLYALGIAADHNLLQRVETDLALCEKLIAQSPIGLALLDPDLRHVLVNPALARIDGMSAEDHVGRGLRETLPLPDIDTIESALRRVLTTGMPMLDQYHVGRLSVDAEDDRAWSLSFYRLEDPGGRVLGAAMSVVDVTERHRAAAEADRARRRLALIADASVRVGTTLEVEETARELAEITVPQLADVVAVDILDSALACRRSRVPDDGPELFRALALKAAHPSEALRAADPPGGLAAYDGDRLVTLCVHSGRPVLVRHVDAQDLPRIARDAEAGSLLARAGVHSYLAVPLIAHGEVIGALDLKRTSNPIPFDEDDVVLATELAGRAAVAIDNARWFQSVRNTALTLQRSLLPDHPPEHSGLELASRYQPAQATSEVGGDWYDVIPLSDDKTALVVGDVMGNGIDAAATMGRLRTATCAYADLDLAPADVLQHLDKITCDLEHYIVTCLYAVYDPRTRLCHVANAGHMPPAVAHPGRSPELLDLPSGAPLGVGGVAFEATTVRLDPGDLLVLYTDGLVETRQHPIDDRLEVLLGFLDEPQRPLEETCDLLLYGLRHPDDHDDVALLIARAV
>NZ_CP013743.1|WP_058927397.1|9274521_9274839_+|hypothetical-protein
MTTYVISVPGTFTGDAGQQTQDELARALRPADPHHTHMGNEEDLDVLTVNDDGTFTVRVTVDAASGPEAEREARRYAEAALDSVGLDEGSAPLGPAVITGIDSGD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP013743_10	10.3\|7314278\|22\|NZ_CP013743\|CRISPRCasFinder	7314278-7314299	22	NZ_CP041223	Porphyrobacter sp. YT40 plasmid pYT40, complete sequence	181001-181022	2	0.909
NZ_CP013743_1	1.1\|251897\|32\|NZ_CP013743\|CRISPRCasFinder	251897-251928	32	NC_016623	Azospirillum lipoferum 4B plasmid AZO_p3, complete sequence	249199-249230	6	0.812
NZ_CP013743_5	5.1\|5470247\|29\|NZ_CP013743\|CRISPRCasFinder	5470247-5470275	29	NZ_CP046575	Rhodococcus sp. WAY2 plasmid pRWAY03, complete sequence	47789-47817	6	0.793
NZ_CP013743_11	11.1\|7443093\|31\|NZ_CP013743\|CRISPRCasFinder	7443093-7443123	31	NZ_CP020568	Kitasatospora aureofaciens strain DM-1 plasmid unnamed1, complete sequence	246433-246463	6	0.806
NZ_CP013743_2	2.1\|3431691\|27\|NZ_CP013743\|CRISPRCasFinder	3431691-3431717	27	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	1118704-1118730	7	0.741
NZ_CP013743_1	1.1\|251897\|32\|NZ_CP013743\|CRISPRCasFinder	251897-251928	32	NC_015383	Burkholderia gladioli BSR3 plasmid bgla_4p, complete sequence	200513-200544	8	0.75
NZ_CP013743_1	1.1\|251897\|32\|NZ_CP013743\|CRISPRCasFinder	251897-251928	32	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	249680-249711	8	0.75
NZ_CP013743_1	1.1\|251897\|32\|NZ_CP013743\|CRISPRCasFinder	251897-251928	32	NZ_CP012748	Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence	1233044-1233075	8	0.75
NZ_CP013743_1	1.1\|251897\|32\|NZ_CP013743\|CRISPRCasFinder	251897-251928	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	4559917-4559948	8	0.75
NZ_CP013743_11	11.1\|7443093\|31\|NZ_CP013743\|CRISPRCasFinder	7443093-7443123	31	NZ_LR027520	Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence	111500-111530	8	0.742
NZ_CP013743_1	1.1\|251897\|32\|NZ_CP013743\|CRISPRCasFinder	251897-251928	32	NC_010625	Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence	68577-68608	9	0.719
NZ_CP013743_1	1.1\|251897\|32\|NZ_CP013743\|CRISPRCasFinder	251897-251928	32	NZ_CP017191	Xanthomonas campestris pv. vesicatoria str. 85-10 plasmid p_XCV_1, complete sequence	78416-78447	9	0.719
NZ_CP013743_1	1.1\|251897\|32\|NZ_CP013743\|CRISPRCasFinder	251897-251928	32	NZ_CP018463	Xanthomonas euvesicatoria strain LMG930 plasmid pLMG930.2, complete sequence	42997-43028	9	0.719
NZ_CP013743_1	1.1\|251897\|32\|NZ_CP013743\|CRISPRCasFinder	251897-251928	32	NC_010878	Thermus sp. 4C plasmid pL4C, complete sequence	3083-3114	9	0.719
NZ_CP013743_1	1.1\|251897\|32\|NZ_CP013743\|CRISPRCasFinder	251897-251928	32	NC_007507	Xanthomonas campestris pv. vesicatoria str. 85-10 plasmid pXCV183, complete sequence	167087-167118	9	0.719
NZ_CP013743_1	1.1\|251897\|32\|NZ_CP013743\|CRISPRCasFinder	251897-251928	32	NC_011758	Methylorubrum extorquens CM4 plasmid pCMU01, complete sequence	297668-297699	10	0.688

1. spacer 10.3|7314278|22|NZ_CP013743|CRISPRCasFinder matches to NZ_CP041223 (Porphyrobacter sp. YT40 plasmid pYT40, complete sequence) position: , mismatch: 2, identity: 0.909

gcgacgggtgctgcccggacgg	CRISPR spacer
ccgacgggtgctgctcggacgg	Protospacer
 *************.*******

2. spacer 1.1|251897|32|NZ_CP013743|CRISPRCasFinder matches to NC_016623 (Azospirillum lipoferum 4B plasmid AZO_p3, complete sequence) position: , mismatch: 6, identity: 0.812

atcggccggcgtggcagcggaggcgaaggaag	CRISPR spacer
ctcggccggctgggcagcggaggcgaccgacg	Protospacer
 *********  **************  ** *

3. spacer 5.1|5470247|29|NZ_CP013743|CRISPRCasFinder matches to NZ_CP046575 (Rhodococcus sp. WAY2 plasmid pRWAY03, complete sequence) position: , mismatch: 6, identity: 0.793

ctggaccggccagaggcgccgggagagcc	CRISPR spacer
ccggaacggccagaggcgccgcgaggagc	Protospacer
*.*** *************** ***.. *

4. spacer 11.1|7443093|31|NZ_CP013743|CRISPRCasFinder matches to NZ_CP020568 (Kitasatospora aureofaciens strain DM-1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.806

gagctgtccctgggcccgggtaggggcggcc	CRISPR spacer
acggtgtccccgggcccgggcaggggcgggc	Protospacer
. * ******.*********.******** *

5. spacer 2.1|3431691|27|NZ_CP013743|CRISPRCasFinder matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.741

gacaatggctcatggggccccggcatg	CRISPR spacer
cggatgggctcatggggccccggcacc	Protospacer
 . *  *******************.

6. spacer 1.1|251897|32|NZ_CP013743|CRISPRCasFinder matches to NC_015383 (Burkholderia gladioli BSR3 plasmid bgla_4p, complete sequence) position: , mismatch: 8, identity: 0.75

atcggccggcgtggcagcggaggcgaaggaag	CRISPR spacer
ctgggccggcgtggccgcggcggcgaagcgct	Protospacer
 * ************ **** ******* .

7. spacer 1.1|251897|32|NZ_CP013743|CRISPRCasFinder matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 8, identity: 0.75

atcggccggcgtggcagcggaggcgaaggaag	CRISPR spacer
aagggccggcgtggcagcggcggcgagcaggg	Protospacer
*  ***************** *****. ...*

8. spacer 1.1|251897|32|NZ_CP013743|CRISPRCasFinder matches to NZ_CP012748 (Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.75

atcggccggcgtggcagcggaggcgaaggaag	CRISPR spacer
cgccgccgtcgtggccgcggaggcgaagaagt	Protospacer
  * **** ****** ************.*.

9. spacer 1.1|251897|32|NZ_CP013743|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 8, identity: 0.75

atcggccggcgtggcagcggaggcgaaggaag	CRISPR spacer
tgcggccgccgtggccgcggaggcgatgtcgg	Protospacer
  ****** ****** ********** *  .*

10. spacer 11.1|7443093|31|NZ_CP013743|CRISPRCasFinder matches to NZ_LR027520 (Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence) position: , mismatch: 8, identity: 0.742

gagctgtccctgggcccgggtaggggcggcc	CRISPR spacer
taaggcccccgtggcccgggtaggggcggcc	Protospacer
 *.   .***  *******************

11. spacer 1.1|251897|32|NZ_CP013743|CRISPRCasFinder matches to NC_010625 (Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence) position: , mismatch: 9, identity: 0.719

atcggccggcgtggcagcggaggcgaaggaag	CRISPR spacer
cgcggcgggcgtggcagcggaagcgatcacgg	Protospacer
  **** **************.****  . .*

12. spacer 1.1|251897|32|NZ_CP013743|CRISPRCasFinder matches to NZ_CP017191 (Xanthomonas campestris pv. vesicatoria str. 85-10 plasmid p_XCV_1, complete sequence) position: , mismatch: 9, identity: 0.719

atcggccggcgtggcagcggaggcgaaggaag	CRISPR spacer
gcccgttggcgcagcagcggaggcgaaggacc	Protospacer
..* *..****..*****************

13. spacer 1.1|251897|32|NZ_CP013743|CRISPRCasFinder matches to NZ_CP018463 (Xanthomonas euvesicatoria strain LMG930 plasmid pLMG930.2, complete sequence) position: , mismatch: 9, identity: 0.719

atcggccggcgtggcagcggaggcgaaggaag	CRISPR spacer
gcccgttggcgcagcagcggaggcgaaggacc	Protospacer
..* *..****..*****************

14. spacer 1.1|251897|32|NZ_CP013743|CRISPRCasFinder matches to NC_010878 (Thermus sp. 4C plasmid pL4C, complete sequence) position: , mismatch: 9, identity: 0.719

atcggccggcgtggcagcggaggcgaaggaag	CRISPR spacer
ggcgggcggcgtggaagcggaggcggggcggg	Protospacer
. *** ******** **********..* ..*

15. spacer 1.1|251897|32|NZ_CP013743|CRISPRCasFinder matches to NC_007507 (Xanthomonas campestris pv. vesicatoria str. 85-10 plasmid pXCV183, complete sequence) position: , mismatch: 9, identity: 0.719

atcggccggcgtggcagcggaggcgaaggaag	CRISPR spacer
gcccgttggcgcagcagcggaggcgaaggacc	Protospacer
..* *..****..*****************

16. spacer 1.1|251897|32|NZ_CP013743|CRISPRCasFinder matches to NC_011758 (Methylorubrum extorquens CM4 plasmid pCMU01, complete sequence) position: , mismatch: 10, identity: 0.688

atcggccggcgtggcagcggaggcgaaggaag	CRISPR spacer
ggcggcaggcgaggcagcggaggcgcccgcga	Protospacer
. **** **** *************   * ..

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP013744

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP013744_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013744_1

26221-26537

Unclear

Consensus_repeat	Method
GTTTCTATGCCCTTNGAGCGGGCGTTGTTCTGAAAT	CRT

4 spacers

cas2,csa3

The CRISPR arrays of NZ_CP013744_1

>merge|NZ_CP013744|1|26221-26537|CRT
GATCATTATCCGTTCGAGCGGGCGTTGTTCTGAAATCCCAAACCTTCACCCAGCAGCGCCGTCGCGGCTTCTTGTTTCTATGCCCTTCGATCGGGCGTTGTTCTGAAATGTGTGCTCAACGTCATCCAGACCAAGGTGTTTCTATGCCCTTCGAGCGGACGTTGTTCTGAAATGCAGGGAATGCAAAAGTCCCGGCAGATCCTGCGGATGGTTTCTATGCCCTTTGAGCGGGCGTTGTTCTGAAACGATTGCGTATCTTGGTAGAAGTCATACCTGGTAAGGTTTCTATGCCCCTTGAGCGGGCGTTGTTCTGAGCT

>NZ_CP013744|1|1|26221-26537|CRT
GATCATTATCCGTTCGAGCGGGCGTTGTTCTGAAAT	CCCAAACCTTCACCCAGCAGCGCCGTCGCGGCTTCTT
GTTTCTATGCCCTTCGATCGGGCGTTGTTCTGAAAT	GTGTGCTCAACGTCATCCAGACCAAGGT
GTTTCTATGCCCTTCGAGCGGACGTTGTTCTGAAAT	GCAGGGAATGCAAAAGTCCCGGCAGATCCTGCGGATG
GTTTCTATGCCCTTTGAGCGGGCGTTGTTCTGAAAC	GATTGCGTATCTTGGTAGAAGTCATACCTGGTAAG
GTTTCTATGCCCCTTGAGCGGGCGTTGTTCTGAGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013744.1\|WP_058928725.1\|17960_18668_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013744.1\|WP_058928736.1\|34549_35152_-\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NZ_CP013744.1\|WP_159104247.1\|19866_20532_-\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319790
NZ_CP013744.1\|WP_058928730.1\|22925_23975_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|223609
NZ_CP013744.1\|WP_058928731.1\|23971_24637_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|334214
NZ_CP013744.1\|WP_079078565.1\|20549_21563_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|366154
NZ_CP013744.1\|WP_058928734.1\|31429_33175_-\|cytochrome-c-biogenesis-protein-ResB	unknown	unknown	gnl\|CDD\|377471
NZ_CP013744.1\|WP_058928943.1\|28497_29439_-\|arsenic-resistance-protein	unknown	unknown	gnl\|CDD\|223869
NZ_CP013744.1\|WP_159104246.1\|18727_19816_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|99740
NZ_CP013744.1\|WP_079078595.1\|26776_27463_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP013744.1\|WP_058928737.1\|35193_35838_-\|vitamin-K-epoxide-reductase-family-protein	unknown	unknown	gnl\|CDD\|240605
NZ_CP013744.1\|WP_058928945.1\|33352_33721_-\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP013744.1\|WP_058928724.1\|17715_17901_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013744.1\|WP_159104245.1\|17419_17704_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013744.1\|WP_159104248.1\|21688_22648_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP013744.1\|WP_058928732.1\|24624_25587_-\|phosphotransferase	unknown	unknown	gnl\|CDD\|270702
NZ_CP013744.1\|WP_058928942.1\|27488_28268_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP013744.1\|WP_058928944.1\|29516_30224_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133398
NZ_CP013744.1\|WP_058928733.1\|30338_31433_-\|c-type-cytochrome-biogenesis-protein-CcsB	unknown	unknown	gnl\|CDD\|274447
NZ_CP013744.1\|WP_058928735.1\|33793_34546_-\|cytochrome-C-biogenesis-protein-ResC	unknown	unknown	gnl\|CDD\|280792

Protein	Function_ID	Function_description	E-value
NZ_CP013744.1\|WP_058928736.1\|34549_35152_-\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.48583e-43
NZ_CP013744.1\|WP_159104247.1\|19866_20532_-\|HAD-IA-family-hydrolase	gnl\|CDD\|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.75144e-20
NZ_CP013744.1\|WP_058928730.1\|22925_23975_+\|radical-SAM-protein	gnl\|CDD\|223609	COG0535, COG0535, Predicted Fe-S oxidoreductases [General function prediction only].	1.21411e-19
NZ_CP013744.1\|WP_058928731.1\|23971_24637_+\|hypothetical-protein	gnl\|CDD\|334214	pfam00696, AA_kinase, Amino acid kinase family. This family includes kinases that phosphorylate a variety of amino acid substrates, as well as uridylate kinase and carbamate kinase. This family includes: Aspartokinase EC:2.7.2.4. Acetylglutamate kinase EC:2.7.2.8. Glutamate 5-kinase EC:2.7.2.11. Uridylate kinase EC:2.7.4.-. Carbamate kinase EC:2.7.2.2.	5.54075e-11
NZ_CP013744.1\|WP_079078565.1\|20549_21563_-\|glycosyltransferase	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	4.81042e-19
NZ_CP013744.1\|WP_058928734.1\|31429_33175_-\|cytochrome-c-biogenesis-protein-ResB	gnl\|CDD\|377471	pfam05140, ResB, ResB-like family. This family includes both ResB and cytochrome c biogenesis proteins. Mutations in ResB indicate that they are essential for growth. ResB is predicted to be a transmembrane protein.	1.03898e-178
NZ_CP013744.1\|WP_159104246.1\|18727_19816_-\|hypothetical-protein	gnl\|CDD\|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	3.63279e-13
NZ_CP013744.1\|WP_079078595.1\|26776_27463_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.71373e-24
NZ_CP013744.1\|WP_058928737.1\|35193_35838_-\|vitamin-K-epoxide-reductase-family-protein	gnl\|CDD\|240605	cd12922, VKOR_5, Vitamin K epoxide reductase family in bacteria. This family includes vitamin K epoxide reductase (VKOR) mostly present in actinobacteria. VKOR (also named VKORC1) is an integral membrane protein that catalyzes the reduction of vitamin K 2,3-epoxide and vitamin K to vitamin K hydroquinone, an essential co-factor subsequently used in the gamma-carboxylation of glutamic acid residues in blood coagulation enzymes. All homologs of VKOR contain an active site CXXC motif, which is switched between reduced and disulfide-bonded states during the reaction cycle. In some bacterial homologs, the VKOR domain is fused with domains of the thioredoxin family of oxidoreductases which may function as redox partners in initiating the reduction cascade.	3.2347e-69
NZ_CP013744.1\|WP_058928945.1\|33352_33721_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	2.29309e-15
NZ_CP013744.1\|WP_058928732.1\|24624_25587_-\|phosphotransferase	gnl\|CDD\|270702	cd05153, HomoserineK_II, Type II Homoserine Kinase. This subfamily is composed of unusual homoserine kinases, from a subset of bacteria, which have a Protein Kinase fold. These proteins do not bear any similarity to the GHMP family homoserine kinases present in most bacteria and eukaryotes. Homoserine kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to L-homoserine producing L-homoserine phosphate, an intermediate in the production of the amino acids threonine, methionine, and isoleucine. The Type II homoserine kinase subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.63122e-12
NZ_CP013744.1\|WP_159104248.1\|21688_22648_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.17866e-43
NZ_CP013744.1\|WP_058928942.1\|27488_28268_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	9.22551e-18
NZ_CP013744.1\|WP_058928943.1\|28497_29439_-\|arsenic-resistance-protein	gnl\|CDD\|223869	COG0798, ACR3, Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism].	2.5894e-41
NZ_CP013744.1\|WP_058928944.1\|29516_30224_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133398	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators. Helix-turn-helix (HTH) heavy metal resistance transcription regulators (HMRTR): MerR1 (mercury), CueR (copper), CadR (cadmium), PbrR (lead), ZntR (zinc), and other related proteins. These transcription regulators mediate responses to heavy metal stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	8.78976e-34
NZ_CP013744.1\|WP_058928733.1\|30338_31433_-\|c-type-cytochrome-biogenesis-protein-CcsB	gnl\|CDD\|274447	TIGR03144, cytochrome_c_biogenesis_protein_chloroplast, cytochrome c-type biogenesis protein CcsB. Members of this protein family represent one of two essential proteins of system II for c-type cytochrome biogenesis. Additional proteins tend to be part of the system but can be replaced by chemical reductants such as dithiothreitol. This protein is designated CcsB in Bordetella pertussis and some other bacteria, resC in Bacillus (where there is additional N-terminal sequence), and CcsA in chloroplast. We use the CcsB designation here. Member sequences show regions of strong sequence conservation and variable-length, poorly conserved regions in between; sparsely filled columns were removed from the seed alignment prior to model construction. [Energy metabolism, Electron transport, Protein fate, Protein modification and repair].	2.52076e-95
NZ_CP013744.1\|WP_058928735.1\|33793_34546_-\|cytochrome-C-biogenesis-protein-ResC	gnl\|CDD\|280792	pfam02683, DsbD, Cytochrome C biogenesis protein transmembrane region. This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange proteins. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.	2.63924e-43

>NZ_CP013744.1|WP_058928732.1|24624_25587_-|phosphotransferase
MTMPFVVNHPDRFGALALRLLADARVPVLSHCPAVRLERGFMMQVDTPAGTFYFKFIPDASHTELRSETTVLSALAARVGWVPRPYDFDGEPFFVAKAWPRSGMAVVGTSCVEGLTLQHADEGLRREIAERVAEMHTVLAARGDVHDAVELRTDYQRLLQLSIAYRELLRVGSFAPAIEVLLNRGVAERPLLPIHGDLRYENLIVKAGALRGIIDFSDARRSTREDELGRFFQYLIYSRGLTPTELTPLLAAYEDRAGYRVDVAGLSLSVAYHTLFRYVHDSRDADTASRAALDDRVRRILTGLARDPGGFCGTSSGYSG
>NZ_CP013744.1|WP_058928731.1|23971_24637_+|hypothetical-protein
MTVDYVIKLGGSLLNDIAAARPFVTKLANTRARCVFTVGSGPLGEFFIALGLERQTNLPFDSSVECWAALQSINARLLCAMSDRLVLAPDYASASRGPAGRHAIIDAFPLAARFARLPHQTADVRAAQIAHDLDCDTLVVFTDVNGVYRTDPKIDAAAVPLRSLPASHPLLRERTSVDEGLAEMLTAYKITAYVAGAPHFTQSPLGLGDYLARCATAIYPE
>NZ_CP013744.1|WP_058928730.1|22925_23975_+|radical-SAM-protein
MSESEGARMREVLLKVVDACPCDCAFCDSNEMFNTRFARRTFELDTWTRITNDLIANGLEVAIITGGDPLSKRQVVIPLIRHLRAAGVFVSVNTSGAQFTSESLLTALLADYPDLLVFSIDSAHAGQHDESRIRPGLFDLIVATISRLKSAGDHPVAIRVVITNRNYTQIPEIIALFHGYGVDCMKFTHIEDDREGDYLLSVDQLRDFDVTVRPRILEVLQGCYFETDALRDDAVMKFTKLLSGNDVTFEQLARGEFSPALSGPTECEIIRRFSVIQSNGQVLPCCESEHHYDPVLGNLATTAASEIFSEKNRRYLKILRNRQSYCTRCTEPHNLQISFRSRMLTVQKR
>NZ_CP013744.1|WP_159104248.1|21688_22648_-|Gfo/Idh/MocA-family-oxidoreductase
MHSAVLRSGVVEGIRLAAVCDVEEERAQKLATAGIPAFDGLSTMVSNCPDIDAVAVLTESGYHAEHALQVLELGRHAIVEKPVDLTNAGVDALAARERADARVAVVHQNRFNTAVVALAGALAQGALGNVVTVAAHVAWGRSEEYYRSGSWRGTRKLDGGALANQGVHHLDILLRLFGPVAGLHALARRRRHAIECEDTISVLLDFADGAQGVLQVTTATDRDYEGSLTVTGTRGFVRLAGECLNRVDRWEAAVPPPTPDPDPSYSALGIPSLYGYGHVAFYRDFVNCVRTSAPFACTLAEARETVRLLNSIYDSCRVA
>NZ_CP013744.1|WP_079078565.1|20549_21563_-|glycosyltransferase
MADVLVTARPAPLMVARRRNPRMPLPPHAVTVIVPVRDRPDLLAKLTKSLASARKAARSEIQGEVVCIVVDDRSKVAPSLPGDLPGRVIASAGPGPGTARNTGAQAATSAWLLFTDSDCAVEPDWLLAAARHLRDPTKHVVQGDPTRYSQSTVYGAREEALYRHMFATYVAADRLRTKMLDSRNLLVRRDALLGVGGFDTSGLDAMAESRTLAARFRAAGTELHYAEDMVVRHEAPASLDHEMAAKFRHGRGRVGVWGRRPPEEAAMAWRYFAEPLGKGMDPGYVFPVHIAFLAGYSHETCASPTDLPTRVLRLLPEAALHSAAIEAGFRWLRRSEG
>NZ_CP013744.1|WP_159104247.1|19866_20532_-|HAD-IA-family-hydrolase
MTPVEAVVWDFDGTLASRPDMWCAAIAEAIHLCGGPPEVTAADFEETAYLHLPWHSPTLGHAFQSSSAEWWEGFLSRVQPLVAAVTGEAAMDVKRFGATVRSIILDPRRYSKIPGSTRAVDALHRRGVLQFVLSNHVPELAGIVSYLFPNRFEEVWTSGQLGVEKPRAEAFHHALDRIGRAPATVLMVGDDVRRDLEPAARLGMRTLHVEDMASTRRGDWL
>NZ_CP013744.1|WP_159104246.1|18727_19816_-|hypothetical-protein
MVTALEGVFDTRFDETPLLAAEAELRHILGFPEVLLTSSATAAAHAVFLRSRADGDTRLGLPAHVFPGIAGAAVTTGLDPVFVPVNRDLIADAAGYDSCDAALVHFPWGDVRGAADLVGRLPQRLVVLDVSHATPRVPRRVWERGGPVAAIGSLGAGKFLSGMEMGFVASNSRAFLRSVAALGAVRREGTFDVPAPVATKLRPHPLAVAVLRAQIRRLPAKLEAHDETWEYLSPRLAEINGVRVVTTSAPAERVFWRCLIDVNPLDGDSAAEYELVKALRTHRLPVSLPEYLDEAVPWTTAYPRPATTREAQQAPGAAVPPPIPRRYLVLPGFVRLPRPDCDELLRGLDAGLRHFRAARRTG
>NZ_CP013744.1|WP_058928725.1|17960_18668_-|hypothetical-protein
MEAVGEALGDLAPDWVDLSVIDHCLQDYAAGVPGGVGLGAYRAAGVPDHVERVDDGFIDALARDVVARVAASRATALTFGSGEFRTWLYKRAGGDASRTRRDLTVFARHLARRASVSGISVLVEPLNRRESPVWNSLRTCAADLEGVKASLVADRQHTWAEVENPRTPALAQVRVVHLGGPGRSVPDEDDVPAMIAQAVSIPGVERVLWECRWTAPQQVAAVLAASRRTLQRSGR
>NZ_CP013744.1|WP_058928724.1|17715_17901_-|hypothetical-protein
MSRISASRLSLPQVLQADELGRGSWHLPGRWRRPSVPICWDQPITEMSDLIFSRANAATLP
>NZ_CP013744.1|WP_159104245.1|17419_17704_+|hypothetical-protein
MLLEQNQALRRDLETVRFELRTIRTRDLATAVRGDLTALPRRDIALEELRKERDQALAAGRLAEADLVVLRSVVQRLMPENTRLLGGPSDTPGS
>NZ_CP013744.1|WP_079078595.1|26776_27463_-|CRISPR-associated-endonuclease-Cas2
MSPPSTVGTQTRPAHPGAAAPVPDGALARWGRFSARHRIAVLVLAVVATVLAGVLGAGAGERMGSGGLTDPDAPSAQAQRLLASRFDAGDPQLVLLAEASGPVDEPGASAAGTALTDRVRGIAGVRGVDSYWSPGRYTYLITYDIADDDRRTTVSDLLAGHGARVQYSVFEVTLPTRKVIQRLRAQLRKRIDRDEDQIRLYPLPGPVLNELVILGNRRIEERADYWIL
>NZ_CP013744.1|WP_058928942.1|27488_28268_-|helix-turn-helix-transcriptional-regulator
MVLHETLSVQRRWSGAVTVEPGRLAFSGAIGSSAPHAHACVQVLMVTVGEVVLADVYGGEVTTRGGAVIPAGVRHEVRALPGARGVSTYVDPSTAAGRLLAARVAASHCEGDRVASWVAFATSAVSGEEGGVEVPLHPRLDRALRLGVQRAGGPPELVELAAAVGISPSRLGHLFADQLGLAYPAWRRWVCLRRAVEAVRAGATLTEAAHDAGFADSAHLSRTCRAMFGLTPTEAVRAAGWRDEGSGSVQAIGGGIGRL
>NZ_CP013744.1|WP_058928943.1|28497_29439_-|arsenic-resistance-protein
MERHQVSVYVGAMAAGALVGWAAPAARPGLEHAIYPVLGTLLYVTFLQVPAAELVRSLRAGRFLAAALVVNFVVVPLVVAAMFAFLPDDQAVRLGVLLVLLAPCVDYVIVFSGLAGGSSQRLLAATPLLLIAQMVLLPGFLFLFMGSDLAYVVEAGPFVEAFLVLIVIPLALAWLTQGWAARRPAGQKVADAMGATMVPLMAATLLTVVASQVPKLNDSVADVARVVPFYVLFLLVMAFAGLGVARLFRLDVPAGRAIVFTGATRNSLVVLPLALALPDRLAIAAVVVVTQTLVEVVGMVIYVRAVPRLLPVS
>NZ_CP013744.1|WP_058928944.1|29516_30224_-|MerR-family-transcriptional-regulator
MQISKLAERTGVPATTLWFYEIAGLLPAERTPAGYRRYGEDAVQRLAFIGAAKHLGLSLEEIAELLGVWQSGACKEVKADLRPRIAARIAEAERSGAELAAFTAALHRALEHLDALPDRSGRCDPQCAILTPDDAVPVQPTAPRADGAGAERWRTAPVACSLSGEGIAERAGQVAALAAAEQQCCPFLDFRLHLGGQDQAHTVEDRHAFGPVLRLEVRAPAEAADVLAELFTPAA
>NZ_CP013744.1|WP_058928733.1|30338_31433_-|c-type-cytochrome-biogenesis-protein-CcsB
MNIAAAANEDMASISNVLIYSAMAVYTLAFLAHITEWVFGSRSKVGRTAAALTQHTVTAPPAAVTVTAARKTGGTTVIERAEVTTRSTTGSRDVPDGPGAAAGDQKGELYGRIAISLTVLAFLVHLGGVVARTVSVQRAPWGNMYEFSTTFSLVAVGGYLLFLTLGKNIRWIGLPLVTSVLLDLGLAVTVLYTDSDQLVPALHSYWLWIHVSCAIISGAMFYLGALATVLYLFRDRYETKLASAEGKQPGPAASSILGRLPAAASLDKFAYRINAVIFPLWTFTIIAGAIWAEAAWGRYWGWDPKETWSFITWVAYACYLHARATAGWKGRKAAYLVLIAFACFIFNYYGVNMFITGLHSYAGV
>NZ_CP013744.1|WP_058928734.1|31429_33175_-|cytochrome-c-biogenesis-protein-ResB
MSKTTTPPRDTSGESSGRSRNASTAEEPALGAAGAQLSTAPSEDRGVPVLGFVGWVRWCWRQLTSMRVALILLFLLSLASIPGSLVPQRGSDPAKVDQYKTDHDVLGPIAEKLQLFNVYSSVWFSAIYILLFISLIGCIVPRSWQFAGQLRGRPPAAPRHLVRLPAHTTWRTDAEPEQVLAAVHRLLKRRRYRAYTAGDAVASEKGYLREVGNLVFHVSLIVMLVAFATGQLWNSEGGKLVVEGDGFSNTLSQYDDLKSGALFDREELPPFGFTLEGFDATYERTGPQKGTPRTFQARISYWEGSDGEPRPSTITVNHPLEVGGSKVYLLGHGYAPVVTVKDGQGTIAYQGPVAFLPQDSNVTSLGVIKVPNYRDAKGSKDQLGFQGVFVPTFGGAGSGSMFSQFPALDFPVMALTAYRGDLGLDSGLPQNVYQLDLKNMKQFVDAKGNKFRKMLRPGETMTLPGGAGSLTFDGIKEWATFQVSYRPGNRLALAGALAALIGLSASLFIQRRRIWVKATPGEDGTTVVEVAGLGRSEWARLPEEVAAVALALRPDAPALPPAQDAPDSVPASADPEQGARS
>NZ_CP013744.1|WP_058928945.1|33352_33721_-|helix-turn-helix-transcriptional-regulator
MSVERPDSCDLLCLDLPVAEDIRARMPQLPGLEQAAAAAKALADPTRLGVAAALAEGGELCVCDVSWVVGQAQNLVSHHLRQLRTAGLAASRRDGRLVMYTLTDRGRHLLQTLLGTTAAKPA
>NZ_CP013744.1|WP_058928735.1|33793_34546_-|cytochrome-C-biogenesis-protein-ResC
MVIAAGLEATVLSGSVLLALPIAALAGAVSFFSPCVLPLVPGYLSYVTGVSGADLAEARRGRILAGTLLFLAGFTAVFVSFGAAFGYAGNTLLEYQDVLIRVLGGATIVMGLSFMGVLPGMSREWRWHHRPAAGLAGAPMLGVLFGLGWTPCIGPTLAAVQALAFTEASATRGAVLTVAYCAGLGLPFLAAGLAFRKALGVFTWVKAHYQWVMRIGGGMMIATGLLMVTGVWSYLISQMQSWSAGFTVGI
>NZ_CP013744.1|WP_058928736.1|34549_35152_-|TlpA-family-protein-disulfide-reductase
MTSTPAGAGARIPRCAAVLALTLAALSAAGCTTQGNDAPPSAGKAVDRQLLQILAADRQAAPDVRGETLTGEQAGLADYRGKIVVINVWGSWCAPCRAEAPHLEKVYEDTRDQGVAFLGINTRDATKTNALNFEKEFGITYPSLWDPAGRQLLKFKGTISPSAIPSTVVIDRKGRIAARALKALSETELRKMIDPLLKQG
>NZ_CP013744.1|WP_058928737.1|35193_35838_-|vitamin-K-epoxide-reductase-family-protein
MTVTAPPTPTQATDTEAGVPVGQRLLAVVLAVGGAIGFLAAFTLTVEKIALLKDPSYSPSCSINPVLSCGSVMTTPQAEVFGFPNPLLGIAGFAVMTAVGVVLLAGAVLPRWFWWGLQAGVVFGVVFVHWLIFQSLYRIGALCPYCMVVWTVMIPVFWYTTVHNLTRGHVPVPGRVRRAATAVAGYHGVVLTAWYLVIVVLILQRFWMYWTTLL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP013744_1	1.1\|26257\|37\|NZ_CP013744\|CRT	26257-26293	37	NZ_CP013744	Streptomyces sp. CdTB01 plasmid unnamed, complete sequence	26257-26293	0	1.0
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP013744	Streptomyces sp. CdTB01 plasmid unnamed, complete sequence	26330-26357	0	1.0
NZ_CP013744_1	1.3\|26394\|37\|NZ_CP013744\|CRT	26394-26430	37	NZ_CP013744	Streptomyces sp. CdTB01 plasmid unnamed, complete sequence	26394-26430	0	1.0
NZ_CP013744_1	1.4\|26467\|35\|NZ_CP013744\|CRT	26467-26501	35	NZ_CP013744	Streptomyces sp. CdTB01 plasmid unnamed, complete sequence	26467-26501	0	1.0
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	KX683423	Mycobacterium phage BabyRay, complete genome	40704-40731	5	0.821
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP021016	Xanthomonas citri pv. phaseoli var. fuscans strain CFBP6991 plasmid pF, complete sequence	97252-97279	5	0.821
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP020890	Xanthomonas citri pv. citri strain TX160197 plasmid unnamed1, complete sequence	91225-91252	5	0.821
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP020883	Xanthomonas citri pv. citri strain TX160042 plasmid unnamed1, complete sequence	35279-35306	5	0.821
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP020886	Xanthomonas citri pv. citri strain TX160149 plasmid unnamed1, complete sequence	122509-122536	5	0.821
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	MN813693	Mycobacterium phage Imvubu, complete genome	38763-38790	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	MN224566	Mycobacterium phage Herbertwm, complete genome	40593-40620	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_KY494864	Pseudomonas aeruginosa strain FFUP_PS_37 plasmid pJB37, complete sequence	278300-278327	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_LT969519	Pseudomonas aeruginosa isolate RW109 genome assembly, plasmid: RW109 plasmid 1	385858-385885	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP029094	Pseudomonas aeruginosa strain AR441 plasmid unnamed3, complete sequence	115400-115427	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NC_023284	Streptomyces sp. F2 plasmid pFRL4, complete sequence	20190-20217	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP040126	Pseudomonas aeruginosa strain PA298 plasmid pBM908, complete sequence	275783-275810	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP016215	Pseudomonas aeruginosa strain PA121617 plasmid pBM413, complete sequence	351119-351146	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	MG592438	Vibrio phage 1.060.A._10N.261.48.B5, partial genome	32114-32141	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	MG592659	Vibrio phage 1.291.O._10N.286.55.F6, partial genome	33693-33720	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NC_018850	Pseudomonas phage UFV-P2, complete genome	7738-7765	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_KU130294	Pseudomonas putida strain 12969 plasmid p12969-DIM, complete sequence	371015-371042	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP039989	Pseudomonas aeruginosa strain T2436 plasmid pBT2436, complete sequence	382677-382704	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP039991	Pseudomonas aeruginosa strain T2101 plasmid pBT2101, complete sequence	399401-399428	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_MN433457	Pseudomonas aeruginosa strain PAB546 plasmid pNK546-KPC, complete sequence	11805-11832	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP029096	Pseudomonas aeruginosa strain AR439 plasmid unnamed2, complete sequence	411176-411203	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP045003	Pseudomonas aeruginosa strain PAG5 plasmid pPAG5, complete sequence	276285-276312	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP045917	Pseudomonas aeruginosa strain CF39S plasmid pCF39S, complete sequence	354641-354668	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	MF344569	Pseudomonas aeruginosa plasmid p12939-PER, complete sequence	456093-456120	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	MF344570	Pseudomonas aeruginosa plasmid pA681-IMP, complete sequence	392356-392383	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP039294	Pseudomonas aeruginosa strain PABL048 plasmid pPABL048, complete sequence	185320-185347	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	CP027478	Pseudomonas koreensis strain P19E3 plasmid p1, complete sequence	35795-35822	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP027170	Pseudomonas aeruginosa strain AR_0356 plasmid unnamed2, complete sequence	243548-243575	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP015879	Pseudomonas citronellolis strain SJTE-3 plasmid pRBL16, complete sequence	263120-263147	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_KY883660	Pseudomonas putida strain SY153 plasmid pSY153-MDR, complete sequence	421962-421989	6	0.786
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	NZ_CP029831	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence	590878-590905	7	0.75
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	MG592657	Vibrio phage 1.287.O._10N.286.55.C7, partial genome	35186-35213	7	0.75
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	MG592654	Vibrio phage 1.284.A._10N.286.55.A5, partial genome	34971-34998	7	0.75
NZ_CP013744_1	1.2\|26330\|28\|NZ_CP013744\|CRT	26330-26357	28	MG592658	Vibrio phage 1.289.A._10N.286.55.E8, partial genome	34695-34722	7	0.75
NZ_CP013744_1	1.1\|26257\|37\|NZ_CP013744\|CRT	26257-26293	37	NZ_CP031166	Euzebya sp. DY32-46 plasmid pEDY32-46I, complete sequence	274939-274975	11	0.703

1. spacer 1.1|26257|37|NZ_CP013744|CRT matches to NZ_CP013744 (Streptomyces sp. CdTB01 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

cccaaaccttcacccagcagcgccgtcgcggcttctt	CRISPR spacer
cccaaaccttcacccagcagcgccgtcgcggcttctt	Protospacer
*************************************

2. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP013744 (Streptomyces sp. CdTB01 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gtgtgctcaacgtcatccagaccaaggt	Protospacer
****************************

3. spacer 1.3|26394|37|NZ_CP013744|CRT matches to NZ_CP013744 (Streptomyces sp. CdTB01 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

gcagggaatgcaaaagtcccggcagatcctgcggatg	CRISPR spacer
gcagggaatgcaaaagtcccggcagatcctgcggatg	Protospacer
*************************************

4. spacer 1.4|26467|35|NZ_CP013744|CRT matches to NZ_CP013744 (Streptomyces sp. CdTB01 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

gattgcgtatcttggtagaagtcatacctggtaag	CRISPR spacer
gattgcgtatcttggtagaagtcatacctggtaag	Protospacer
***********************************

5. spacer 1.2|26330|28|NZ_CP013744|CRT matches to KX683423 (Mycobacterium phage BabyRay, complete genome) position: , mismatch: 5, identity: 0.821

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gcaagcccaacgtcatcgagaccaaggt	Protospacer
*.. **.********** **********

6. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP021016 (Xanthomonas citri pv. phaseoli var. fuscans strain CFBP6991 plasmid pF, complete sequence) position: , mismatch: 5, identity: 0.821

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gtgtgctcaacgtcggccagaccgaaat	Protospacer
**************. *******.*..*

7. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP020890 (Xanthomonas citri pv. citri strain TX160197 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.821

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gtgtgctcaacgtcggccagaccgaaat	Protospacer
**************. *******.*..*

8. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP020883 (Xanthomonas citri pv. citri strain TX160042 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.821

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gtgtgctcaacgtcggccagaccgaaat	Protospacer
**************. *******.*..*

9. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP020886 (Xanthomonas citri pv. citri strain TX160149 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.821

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gtgtgctcaacgtcggccagaccgaaat	Protospacer
**************. *******.*..*

10. spacer 1.2|26330|28|NZ_CP013744|CRT matches to MN813693 (Mycobacterium phage Imvubu, complete genome) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gtctgctcaacgccatccagaccacccg	Protospacer
** *********.***********

11. spacer 1.2|26330|28|NZ_CP013744|CRT matches to MN224566 (Mycobacterium phage Herbertwm, complete genome) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
agaagcccaacgtcatcaagaccaaggt	Protospacer
. . **.********** **********

12. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_KY494864 (Pseudomonas aeruginosa strain FFUP_PS_37 plasmid pJB37, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

13. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_LT969519 (Pseudomonas aeruginosa isolate RW109 genome assembly, plasmid: RW109 plasmid 1) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

14. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP029094 (Pseudomonas aeruginosa strain AR441 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

15. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NC_023284 (Streptomyces sp. F2 plasmid pFRL4, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gcaacctcaacgtcctcaagaccaaggt	Protospacer
*..  ********* ** **********

16. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP040126 (Pseudomonas aeruginosa strain PA298 plasmid pBM908, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

17. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP016215 (Pseudomonas aeruginosa strain PA121617 plasmid pBM413, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

18. spacer 1.2|26330|28|NZ_CP013744|CRT matches to MG592438 (Vibrio phage 1.060.A._10N.261.48.B5, partial genome) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gcttgctcaacgtcatccataccagcga	Protospacer
*. **************** ****. *

19. spacer 1.2|26330|28|NZ_CP013744|CRT matches to MG592659 (Vibrio phage 1.291.O._10N.286.55.F6, partial genome) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gattgctcaacgtcatccataccagcga	Protospacer
*  **************** ****. *

20. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NC_018850 (Pseudomonas phage UFV-P2, complete genome) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
tggtgctcaacgccatccacaccaatgg	Protospacer
  **********.****** ***** *

21. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_KU130294 (Pseudomonas putida strain 12969 plasmid p12969-DIM, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

22. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP039989 (Pseudomonas aeruginosa strain T2436 plasmid pBT2436, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

23. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP039991 (Pseudomonas aeruginosa strain T2101 plasmid pBT2101, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

24. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_MN433457 (Pseudomonas aeruginosa strain PAB546 plasmid pNK546-KPC, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

25. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP029096 (Pseudomonas aeruginosa strain AR439 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

26. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP045003 (Pseudomonas aeruginosa strain PAG5 plasmid pPAG5, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

27. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP045917 (Pseudomonas aeruginosa strain CF39S plasmid pCF39S, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

28. spacer 1.2|26330|28|NZ_CP013744|CRT matches to MF344569 (Pseudomonas aeruginosa plasmid p12939-PER, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

29. spacer 1.2|26330|28|NZ_CP013744|CRT matches to MF344570 (Pseudomonas aeruginosa plasmid pA681-IMP, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

30. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP039294 (Pseudomonas aeruginosa strain PABL048 plasmid pPABL048, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

31. spacer 1.2|26330|28|NZ_CP013744|CRT matches to CP027478 (Pseudomonas koreensis strain P19E3 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

32. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP027170 (Pseudomonas aeruginosa strain AR_0356 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

33. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP015879 (Pseudomonas citronellolis strain SJTE-3 plasmid pRBL16, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

34. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_KY883660 (Pseudomonas putida strain SY153 plasmid pSY153-MDR, complete sequence) position: , mismatch: 6, identity: 0.786

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
atcggctcaacgtcatccagatcaaagg	Protospacer
.*  *****************.***.*

35. spacer 1.2|26330|28|NZ_CP013744|CRT matches to NZ_CP029831 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed7, complete sequence) position: , mismatch: 7, identity: 0.75

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
tgctgctcaccgtcatccagaccatgtc	Protospacer
   ****** ************** * .

36. spacer 1.2|26330|28|NZ_CP013744|CRT matches to MG592657 (Vibrio phage 1.287.O._10N.286.55.C7, partial genome) position: , mismatch: 7, identity: 0.75

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gcttgctcaacgtcatccataccagcaa	Protospacer
*. **************** ****. .

37. spacer 1.2|26330|28|NZ_CP013744|CRT matches to MG592654 (Vibrio phage 1.284.A._10N.286.55.A5, partial genome) position: , mismatch: 7, identity: 0.75

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gcttgctcaacgtcatccataccagcaa	Protospacer
*. **************** ****. .

38. spacer 1.2|26330|28|NZ_CP013744|CRT matches to MG592658 (Vibrio phage 1.289.A._10N.286.55.E8, partial genome) position: , mismatch: 7, identity: 0.75

gtgtgctcaacgtcatccagaccaaggt	CRISPR spacer
gcttgctcaacgtcatccataccagcaa	Protospacer
*. **************** ****. .

39. spacer 1.1|26257|37|NZ_CP013744|CRT matches to NZ_CP031166 (Euzebya sp. DY32-46 plasmid pEDY32-46I, complete sequence) position: , mismatch: 11, identity: 0.703

cccaaaccttcacccagcagcgccgtcgcggcttctt	CRISPR spacer
cgttgctgctcagccagcagcgccgttgcggcttctg	Protospacer
* . . . .*** *************.*********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

60778 : 113051

Streptomyces_phage(50.0%)

transposase,integrase,protease

attL 47745:47763|attR 88508:88526

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
47745:47763	attL	NA	NA	NA	NA
WP_058928754.1\|60778_61681_+\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_058928755.1\|61769_62234_-	hypothetical protein	NA	NA	NA	NA
WP_159104250.1\|62255_62459_-	hypothetical protein	NA	NA	NA	NA
WP_079078566.1\|62802_64128_+	putative lipid II flippase FtsW	NA	NA	NA	NA
WP_058928757.1\|64250_65114_-	undecaprenyl-diphosphate phosphatase	NA	NA	NA	NA
WP_159104251.1\|65496_65664_+	hypothetical protein	NA	NA	NA	NA
WP_079078567.1\|65981_66530_-	hypothetical protein	NA	NA	NA	NA
WP_058928760.1\|66480_68661_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_058928761.1\|68657_70436_-	hypothetical protein	NA	NA	NA	NA
WP_058928762.1\|70435_71821_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_063824642.1\|71983_72754_-	MFS transporter	NA	NA	NA	NA
WP_079078568.1\|72750_73227_-	NUDIX domain-containing protein	A0A0M4RQ80	Streptomyces_phage	8.8e-13	36.3
WP_058928763.1\|73588_75157_+\|integrase	integrase	NA	NA	NA	NA
WP_079078569.1\|75189_77052_+	hypothetical protein	NA	NA	NA	NA
WP_058928765.1\|77048_79190_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_058928766.1\|79186_79606_+	hypothetical protein	NA	NA	NA	NA
WP_058928767.1\|79665_80166_-	hypothetical protein	NA	NA	NA	NA
WP_058928769.1\|81544_81904_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_058928770.1\|82167_82668_+	SH3 domain-containing protein	NA	NA	NA	NA
WP_063824647.1\|82782_83790_+	hypothetical protein	NA	NA	NA	NA
WP_058928772.1\|83944_84145_+	hypothetical protein	NA	NA	NA	NA
WP_107416343.1\|84318_85269_+	cation transporter	NA	NA	NA	NA
WP_058928774.1\|85299_86109_+	hypothetical protein	NA	NA	NA	NA
WP_058928775.1\|86154_86907_+	DivIVA domain-containing protein	NA	NA	NA	NA
WP_058928776.1\|87116_88232_+	esterase	NA	NA	NA	NA
WP_079078572.1\|88352_90200_+	DUF2156 domain-containing protein	NA	NA	NA	NA
88508:88526	attR	NA	NA	NA	NA
WP_079078573.1\|90743_91982_-	aminotransferase class V-fold PLP-dependent enzyme	NA	NA	NA	NA
WP_058928777.1\|92807_93455_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_107416344.1\|93475_94312_-	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_079078574.1\|94780_95257_+	hypothetical protein	NA	NA	NA	NA
WP_058928778.1\|95268_95688_+	hypothetical protein	NA	NA	NA	NA
WP_058928779.1\|95785_96448_+	DUF3105 domain-containing protein	NA	NA	NA	NA
WP_058928954.1\|96551_97160_+	DUF305 domain-containing protein	NA	NA	NA	NA
WP_058923184.1\|97630_97996_-	peptidoglycan-binding protein	NA	NA	NA	NA
WP_058923185.1\|98382_100281_-	hypothetical protein	NA	NA	NA	NA
WP_058928170.1\|100280_100784_-	hypothetical protein	NA	NA	NA	NA
WP_058928780.1\|102764_103184_+	hypothetical protein	NA	NA	NA	NA
WP_058928781.1\|103426_103648_-	hypothetical protein	NA	NA	NA	NA
WP_058928782.1\|103733_104141_-	hypothetical protein	NA	NA	NA	NA
WP_058928783.1\|104449_106990_-	peptide synthetase	NA	NA	NA	NA
WP_079078575.1\|107613_108741_+	cation transporter	NA	NA	NA	NA
WP_058928784.1\|108750_109806_+	mechanosensitive ion channel	NA	NA	NA	NA
WP_058928785.1\|110409_110904_-	hypothetical protein	NA	NA	NA	NA
WP_058928786.1\|110986_111286_-	hypothetical protein	NA	NA	NA	NA
WP_058928787.1\|111282_111630_-	hypothetical protein	NA	NA	NA	NA
WP_079078576.1\|112634_113051_+\|transposase	transposase	Q6H9S4	Enterobacteria_phage	2.1e-10	41.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP013743

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP013744

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection