CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP011502	Aeromicrobium erythreum strain AR18 chromosome, complete genome	17 crisprs	csa3,DEDDh,cas3,DinG,WYL	1	4	0	0

Cas Category Instructions

Results visualization

1. NZ_CP011502

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP011502_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_1

72936-73042

Orphan

Consensus_repeat	Method
GATTCCCAGGTCCACCTGGGAATCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011502_1

>merge|NZ_CP011502|1|72936-73042|CRISPRCasFinder
GATTCCCAGGTCCACCTGGGAATCTCCCAGCGAGGCACGATTTTCTGACGTTTGCACGGAAAGCACTCCGTGCTTCGCTGGGATTCCCAGGTCGACCTGGGAATCTC

>NZ_CP011502|1|1|72936-73042|CRISPRCasFinder
GATTCCCAGGTCCACCTGGGAATCTC	CCAGCGAGGCACGATTTTCTGACGTTTGCACGGAAAGCACTCCGTGCTTCGCTGG
GATTCCCAGGTCGACCTGGGAATCTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_144433846.1\|76114_76825_-\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|376566
NZ_CP011502.1\|WP_067861129.1\|62428_62983_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|132427
NZ_CP011502.1\|WP_067853122.1\|74837_75461_+\|DUF4232-domain-containing-protein	unknown	unknown	gnl\|CDD\|379419
NZ_CP011502.1\|WP_067853127.1\|77106_78477_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|235337
NZ_CP011502.1\|WP_067853105.1\|62984_63794_+\|TIGR03084-family-protein	unknown	unknown	gnl\|CDD\|274423
NZ_CP011502.1\|WP_162492508.1\|67992_69528_+\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|178415
NZ_CP011502.1\|WP_067853107.1\|63816_64152_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853124.1\|75467_76118_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380065
NZ_CP011502.1\|WP_083516149.1\|64911_66750_+\|DUF1446-domain-containing-protein	unknown	unknown	gnl\|CDD\|377804
NZ_CP011502.1\|WP_067853137.1\|85273_86881_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|365906
NZ_CP011502.1\|WP_067853109.1\|64382_64913_-\|exonuclease-SbcC	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853117.1\|73071_73818_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|236109
NZ_CP011502.1\|WP_067853130.1\|78566_82916_+\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NZ_CP011502.1\|WP_083516151.1\|82979_85127_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226482
NZ_CP011502.1\|WP_067861133.1\|66767_67928_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173849
NZ_CP011502.1\|WP_067853140.1\|86877_87822_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|309685
NZ_CP011502.1\|WP_067853119.1\|73831_74662_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853102.1\|60453_62229_-\|DUF3352-domain-containing-protein	unknown	unknown	gnl\|CDD\|371750
NZ_CP011502.1\|WP_067853111.1\|69835_71770_+\|biotin/lipoyl-binding-protein	unknown	unknown	gnl\|CDD\|227111
NZ_CP011502.1\|WP_067853114.1\|71766_72930_+\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_144433846.1\|76114_76825_-\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|376566	pfam01557, FAA_hydrolase, Fumarylacetoacetate (FAA) hydrolase family. This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyzes fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerises this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase.	7.15499e-54
NZ_CP011502.1\|WP_067861129.1\|62428_62983_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|132427	TIGR03384, betaine_BetI, transcriptional repressor BetI. BetI is a DNA-binding transcriptional repressor of the bet (betaine) regulon. In sequence, it is related to TetR (pfam00440). Choline, through BetI, induces the expression of the betaine biosynthesis genes betA and betB by derepression. The choline porter gene betT is also part of this regulon in Escherichia coli. Note that a different transcriptional regulator, ArcA, controls the expression of bet regulon genes in response to oxygen, as BetA is an oxygen-dependent enzyme. [Regulatory functions, DNA interactions].	3.99844e-10
NZ_CP011502.1\|WP_067853127.1\|77106_78477_+\|alpha/beta-hydrolase	gnl\|CDD\|235337	PRK05077, frsA, esterase FrsA.	4.10588e-14
NZ_CP011502.1\|WP_067853105.1\|62984_63794_+\|TIGR03084-family-protein	gnl\|CDD\|274423	TIGR03084, conserved_hypothetical_protein, TIGR03084 family protein. This family, like pfam07398, belongs to the larger set of probable enzymes modeled by TIGRFAMs family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized. [Hypothetical proteins, Conserved].	5.0966e-109
NZ_CP011502.1\|WP_162492508.1\|67992_69528_+\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|178415	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain.	0
NZ_CP011502.1\|WP_067853124.1\|75467_76118_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380065	pfam17939, TetR_C_30, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in the Pseudomonas aeruginosa PsrA which regulates the fadBA5 beta-oxidation operon. Functional analysis of PsrA indicated its importance in regulating b-oxidative enzymes. It has also been suggested that PsrA, a member of the TetR family of repressors, could affect global gene expression including activation of rpoS.	8.21943e-12
NZ_CP011502.1\|WP_083516149.1\|64911_66750_+\|DUF1446-domain-containing-protein	gnl\|CDD\|377804	pfam07287, AtuA, Acyclic terpene utilisation family protein AtuA. This family consists of several bacterial and plant proteins of around 400 residues in length. One member of this family has been characterized in Pseudomonas citronellolis as AtuA, a member of a gene cluster that is essential for the acyclic terpene utilisation (Atu) pathway.	0
NZ_CP011502.1\|WP_067853137.1\|85273_86881_+\|metallophosphoesterase	gnl\|CDD\|365906	pfam00149, Metallophos, Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.	4.84534e-06
NZ_CP011502.1\|WP_067853117.1\|73071_73818_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|236109	PRK07827, PRK07827, enoyl-CoA hydratase family protein.	2.20268e-79
NZ_CP011502.1\|WP_067853130.1\|78566_82916_+\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	4.33217e-07
NZ_CP011502.1\|WP_083516151.1\|82979_85127_+\|AAA-family-ATPase	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	2.90471e-73
NZ_CP011502.1\|WP_067861133.1\|66767_67928_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	5.5904e-126
NZ_CP011502.1\|WP_067853140.1\|86877_87822_+\|hypothetical-protein	gnl\|CDD\|309685	pfam04655, APH_6_hur, Aminoglycoside/hydroxyurea antibiotic resistance kinase. The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation utilising ATP. Likewise hydroxyurea is inactivated by phosphorylation of the hydroxy group in the hydroxylamine moiety.	5.8479e-33
NZ_CP011502.1\|WP_067853114.1\|71766_72930_+\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	2.62573e-87
NZ_CP011502.1\|WP_067853102.1\|60453_62229_-\|DUF3352-domain-containing-protein	gnl\|CDD\|371750	pfam11832, DUF3352, Protein of unknown function (DUF3352). This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 538 to 575 amino acids in length.	3.91697e-09
NZ_CP011502.1\|WP_067853111.1\|69835_71770_+\|biotin/lipoyl-binding-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP011502.1\|WP_067853122.1\|74837_75461_+\|DUF4232-domain-containing-protein	gnl\|CDD\|379419	pfam14016, DUF4232, Protein of unknown function (DUF4232). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.	2.60634e-20

>NZ_CP011502.1|WP_067853114.1|71766_72930_+|acyl-CoA/acyl-ACP-dehydrogenase
MSQFTESEERRELRKAVASLGAKYGEKYFHEAAAEGRKTTELWAEAGRLGYLGVSIPEEFGGGGGDIGDLAAVCEELATAGCPLLLMVVSPAIVGTTIAQYGTQEQKERWLPGLADGTATYAFSITEPDAGSNSHNIVTHAEKAEDGSWVLNGTKTYISGVDEASHLLVVARYSDARTGKLKPALFMVPTDADGFTKQQIEMGVVSPEKQFTLFFDDVRVAADALVGQEDAGLEQLFAGLNPERIMAASMATGTARWAIRKAVAYAKEREVWGKPIGAHQAISHPLARLHIDVEMARLLTQKAAALYAAGDLMGAGEAANMAKVAAGEAAAKAVDQAIQTHGGNGLALEYGLVQAVASSRLSNIAPVSKEMALNFVAQFSLGLPKSY
>NZ_CP011502.1|WP_067853111.1|69835_71770_+|biotin/lipoyl-binding-protein
MIRTVLVANRGEIARRVFRTCRDLGIRTVAVHSDADASAPFVAEADVAVRLEGNAPGETYLRADLVVDAARRAGADAVHPGYGFLSENAGFARAVADAGLTWIGPTPESIDAMGSKIRAKELMADAGVPILSVDPATARPEDFPLLVKASAGGGGRGMRVVERAEDLEGELTAAAAEAASAFGDDTVFVEPYLPTARHVEVQVLADTHGTTWILGDRDCSLQRRHQKVVEEAPAPNLSDPVRRTLHDAARNAAEAVGYVGAGTVEFLVADGHADDGRVYFLEMNTRLQVEHPVTEEVFGVDLVALQLSVAEGHPLPAERPAGPSGHAVEVRLYAEDPADDYAPQTGTLRTFEVPEGPGLRTDSAVESGSVVTHFYDAMIAKVVAHGADRAQAVRRLDDALRRTRVHGLTTNLGLLRGALADEEFAAGRVHTALLGERIEAWTRPLLDDDAVRRSALAAALAQARSASTSSPVLSRIPTAFRNVPSQPRTRRLRLGDDELVVEYRAEGGRLVSDLADVVSVEPERVVLAVDGVTEAYRVAVGEETVDVDGPAGSLSFDVVPTFVDPADVLAEGSLLAPMPASVVKVGVEAGQQVEKGDVVVVLEAMKMQHTITAPTDGVVAELAVTAGQQVESGAVLAVIEGDPA
>NZ_CP011502.1|WP_162492508.1|67992_69528_+|acyl-CoA-carboxylase-subunit-beta
MLERVADLAEQHAKALAGGGEKYVARHHARGKLTARERIELLVDPDTPFLELGALAGWGTDFTVGGSIITGIGVVEGVECMIVANDPTVKGGSSNPVTVKKGFRAAQVAEENGLPTINLVESGGADLPTQKDIFIPGGASFRNITRASEDRRPTVALVFGNSTAGGAYIPGMSDYVIMVDGGAKVFLGGPPLVKMATGEESDDESLGGASMHAKTSGLADYLAVDEHDAIRLGRQVVRRLNWRKKGATPRADYAEPVLDGEDLLGIVPTDLKIPFDPREVIARLVDGSEFDEFKPLYGSSLVTGYAQLHGYPIGILANAQGVLFSAEAQKAAQFIQLANQTDTPLLFLHNTTGYMVGAEYEQGGIIKHGAQMINAVSNSKVPHLSVVMGASYGAGHYGMSGRAYDPRFMFSWVGAKSAVMGPAQLAGVMEIVARQSAESKGQPFDAEGFRGVKDYVEQQIEEQSLAYFTSGMGYDDGVIDPRDTRAILGICLSAIHTAPVEGARGYGVFRL
>NZ_CP011502.1|WP_067861133.1|66767_67928_+|acyl-CoA-dehydrogenase-family-protein
MFATPERQALRTAVEQFTTREIVPHLPQWEDDGQLPRELHAATAKAGFLAVGYPEEVGGAGGDAVDACVVTEAMLAAGGSTGLQASLFTHSIALPHIIDAASSGAGGSRLVDLYVRPTLAGEKIGSLGVTEPSGGSDVANIRTRAVRDGDHYVVNGAKTFITSGVRADFVTTAVRTGGDGHAGISLLVIDKDTPGFTVSRSLRKMGWHCSDTAELAFDDVRVPVENLVGEENGGFYLVMQQFVGERLGLAVQAYGTAQRALDLAVAYARERDTFGKPLIARQVIRHKLVEMHARTSAARALTRQALVRSLETPKTDPSLILDAVTAKNVAVAAVEHVVHEAVQVFGGMGYMRESEIDRHYRDARILGIGGGATEVMKDLSAKLLGY
>NZ_CP011502.1|WP_083516149.1|64911_66750_+|DUF1446-domain-containing-protein
MPSWCRVVGGPSKNKQAGLTVCNVRCDAAEVTVRIGNCSGYYGDRPTAFREMLEGGELDYLTGDYLAELTMLILGKDRMKDPEAGYAKTFLRQLQDGLALAREKGVKVVANAGGLNPAGLAARIRELAQEQGIDVQVAHVEGDDLLPRAAELGLSDVGGGSLLTANAYLGAFGIAAALDAGADVVVTGRVTDASVVMGPAIHAHGWGRDDLDALAGALVAGHVIECGTQATGGNFSGFRDLDTWRPLGFPVAEVDADGSSVITKHASTGTTETGGAVTVDTVTAQLLYEVQGPAYLNPDVVAHLDTLALTQEGPDRVRISGVRGTPPPATTKVCLNLLGGFRNGVDLLLTGLDIEAKAAWVRREVEAALQDDPPDELVWTLDRTDVYDPPTQASATSYLRCAAKSSRPEPVGRAFSDAFVNVALASYPGFTLTAPPGRGTPYGVYRPAYVPQSEVPHVVVHADGRREDVAPPATTADVAVEPADVTAAPDLGASQPRPLGELVHARSGDKGGDANVGLWIPADHPRRADAVAWLVGIVNAGWVQGMLPEAADLDVDVHPLPNLGGVNVVVHGLLGEGVSSSTRLDPQAKAVGEWLRARVTAVPTRLLEGRRP
>NZ_CP011502.1|WP_067853109.1|64382_64913_-|exonuclease-SbcC
MPTPPGLDLTVEELRAVVRFAAACAADVLPVFESAVDDDARPREALDAARAFADGAARSNRQRTTAFAAHRAARDAPDEVARLAALACADAAGAAYLHPLAQATQVGHVLRSAACVARVAELRGEDVGVVRATLAERAAPPVPAVLRRYPRPRRGRTRLEELLVVLDTAVRGSDAR
>NZ_CP011502.1|WP_067853107.1|63816_64152_-|hypothetical-protein
MSSLVNEQPAPTTGGVPLPQPRPVWVGCLWQHDDGPMKETVPAWATHRSGKLILCDFWDPRTGDERAHWMEASFVRPRPIRTRTPQLRRHPAAAPSPRTVVPGTPRPRSQE
>NZ_CP011502.1|WP_067853105.1|62984_63794_+|TIGR03084-family-protein
MSSTSPRERLEQVLADLAAEGDQLDGWVADLPIQEWGAVTTPEGWTVAHQVGHLAWTDETSLAAVTDAEAFGALLKEAAQDPTGYVDTAADTWAAKPVPMLLDAWRAGRDALADALRAVPDGERVPWFGPPMSPTSMASARFMETWAHAHDVAETFGIEVPRTDRVRHVCHLGVRTRGFAYVMRGEEPPTSEVRVELAAPSGETWTWGEEGAEQRVTGDAWDFALLATRRRHRDDVDVRADGADADHWLDVAQAFAGLPGADPKRLSER
>NZ_CP011502.1|WP_067861129.1|62428_62983_+|TetR-family-transcriptional-regulator
MRLRLMEATVECLVELGWSGTSTTVVSQRAGVSRGAQLHHFPSKQALVVGAVEHLTERRRHAMADTVRTLPDVGRTRAVLDVLAEQFTSPVFFAALELWVAARTDPDLREAVAPLERRVGRETHAYALELLDVDEQRGRNRELVQATLDLLRGLGLAGTLTDDSRRRAAVLDAWAVTLDTGLER
>NZ_CP011502.1|WP_067853102.1|60453_62229_-|DUF3352-domain-containing-protein
MSDETPTSPPPPPAPDGPATPDATVEQPAAPEAASAAGGGNGKKIALGIGAVVAVAAVGGGAYAWTQLSGGGTQPHNVLPADTIAYVRLDLDPSASQKIDLFRLARRVPELSQELGIKDEGDDLRKIVLEDALKGCDDVDYAKDVEPWLGERVGLGVGPNLQDEEESLRIAVQVTDETAAKAGIGKLFGCSGEEFGIGFLDGYAIVTPTQKSADAAVKAASSESLADDADFARDQDALDEQGVLSGWVDVKDGLAAIKKAGIDDVLGPDAAQLETLADETSSLAFALSASSTSLTLDAVAHEGDKPTKLPQVRGLGALPEDTVVGLTVPGGGKAVEENWDEIKTSLGDLLSLRDFFTVPGLGSPSPQPEFDAEAYAADPEGYEEEYLAQLQQQTAPPSASSADVDATLEEIEKTLDVTLPDDLVTLLGDAFSVYVGREGLEDIAGPQGPADPADVAVGLVTEGDEAKAADLADRLTASLQRLAGVELATSTGDDADSIATSPKVAKELVEDGDLAGTDLFSSVIDGDGEAGGLFVDVGAILDAVAKAEPAVEQDDVFTSLRNIAAVGFSSTSPQDGYTGFSASVAFTERKQ
>NZ_CP011502.1|WP_067853117.1|73071_73818_+|enoyl-CoA-hydratase/isomerase-family-protein
MAELVHLDVADGVATVTLDSEHNRNALSRQLVTELADRLAQADADADVRAVLVRSAHRVFCSGADLSEAASGGMEEGARAIVALQRQIATAGTPVVVELAGPVRAGGLGIVGAADVVVAAESVTFALSEVRLALAPAVISLTLLERFTDRAAAELFLTGRQFDAREAQAAGLVTRAVPDADLAAAVAAVLADLVQGYPQGLRETKRLLNHDLVARIDALGDDVAAQSARLFGSDEAREAMTAFLQRKR
>NZ_CP011502.1|WP_067853119.1|73831_74662_-|hypothetical-protein
MIRRPEQRRSAHRRPTNRTVLAALALVAGSVALAAPAEAATYGVTLTASHAQRDVGQKLTLSGKVSGAKAAGKKLAVQRRVGTGAWRTIATPRTTKTRTFASRVTVSRTGTQQYRVVAPAAGSTQRGVSPARTVTGWTWLDLYDESYYSSGGVQRGWVGTVNGGTPPRETLGLYSSDGNAGSHGFVGWRSEGQCDRVTAAIGLSDGDSTAKYVRLEAGGPAQLLEVQPSEITKVDVPLVDDAGFSLRRFEGSGGGYVVVESPRAHCRVDRMPIAYD
>NZ_CP011502.1|WP_067853122.1|74837_75461_+|DUF4232-domain-containing-protein
MKTLPLVVAGALLLLTAGCSSHDASDPSVGSGRPSPTSTAPSSTTAPSTTGSSASATPTPTSSPSTSSAPTCTTADLRVTVRPDPNGAAAGSTFDDVLLRNTGGTTCLMTGWPGVSFVTGSQGRQVGAPAARQGTPAVVSLAPGASAEALLQVAEAGNFAPCTTTPVRGLRVYPPNQRDAVFVPLPTKACAQTSAQQLTVRPVVLRG
>NZ_CP011502.1|WP_067853124.1|75467_76118_-|TetR/AcrR-family-transcriptional-regulator
MSRTSTDASPAPRRRPREELREVLLDVAERSFARSGYAGVGVREITRDAGVRTATVSEVFGGKRELFRAVLLRRVEPLNAARRVRLAGATSLDDVVRAFTEPMLEQAGRPGWADYFRFVAQLSVSALPEQVLVAEEYNAIAATFVGRLQDLYPDARPEAVLDAYLLLVTSSLQLFAGPGRFEYLTEGAPAAPDLATRHDWLVQFVSGGLDTLLRGV
>NZ_CP011502.1|WP_144433846.1|76114_76825_-|fumarylacetoacetate-hydrolase-family-protein
MLFEQHTIDASRGLVRRFHPAQYRAARAVELLTRRPFPAFRPHRLLQEQPIYYLGNHLTFVPSGTEIRPPSYSSALDYELELGFVLARPLLDATPEEATAAIGGFVLVNDLSARDVQRREMASGFGPQKSKHFASSMSEVLVTAEAVLPHVDALQGRVVVNGEVVAEVSTAGMRWSLGEVLAHASRSERLLPGELFATGTLPGGSGMETGRWIGPGDELELVLDGVGRVEHRVLPA
>NZ_CP011502.1|WP_067853127.1|77106_78477_+|alpha/beta-hydrolase
MSSSGSASFVRRLLVTTCAATRTTGLAARFTGTAPFLPALFVLRYSNMGGLDPAVVATHLARCRTFGDRGWTTYWHRLAAEQLTVAESALGRVAGTDLSGRLVSAATSGEVVLPDVALGTLEDAAVLMADHGPQPTPDDVSRVVGTGRPEVLDAFTALDAWVKALTLEQVAAFPGHTPGRMRAYWRSRRLFDALVPVVTPRLGVDVRPVDVPVDGDVVRGYLVTPRDGGPRPVVLVTNGLEGTVQELLLPLLRYRESGLATFVMEMPGSYAYGQPMSPASEDVYGAVVDHLVRDPRVEGTRLGVVGVSFGGYWAARLAVVEPRLTCAVACGAPTNRTFLPGNAIGLPQVILEALKAVTGSRALLTMSHRLRTLSLRRRYRDVRVPLLVVNGDHDTLLSTQDSIDLAEQAPGASLLLYPDDDHCAMGHYRDWLDASQQWLVRHLAPPVDAPAPAGGD
>NZ_CP011502.1|WP_067853130.1|78566_82916_+|carboxypeptidase-regulatory-like-domain-containing-protein
MGASRAAARGCVLLVVSVLATLLGVAPAHAAPVALSGSVVGTSGAGLSGIEVAVTTRAGVAVQETTTDSTGAWSVQVEPGTYAVGYVDPEGWWKPEFWDDQTTLAASTALTVGTSGRTGVVARLAPYPVVSGTVRSGGEPVAGAEVRAYASANETDSVRVVTTAADGTWAVPLPSGSYRFAFESPDHVVEYWNDRATLAASDPVTVTTADVPGRDVTLTPLPVASGRVTAGGAAVRRPEVTVLVRDAATGLWSEQETVTGDAQGRWSVRLVAGRYSFRFAGDARYRPEFWADQTRRSDATPVDLGSAPVVLDADLAVLPTARGLVRDASGEPVEDADVVALDASGDEVARDRTGPDGVFGVPLAPGAYGVEVRARGYRTWTRSVVDDPLLVGQRGGDVGTVDLAPALAIRGRVTGPDGSPVRTDVVVHAPRVVAGQTRWVVADRVSTDASGRWSAPVVPGDYRLQVEGTDDLAGEFWDDAASLAAARTVTVGDADVLARDTVLAARSRSGVRGTVTTATGGALADARVSASVLRDGEWVVLDETTTAADGRYRLLLPDGTYRLGFSADRHRTTFGPGSATVGAAPSVVVAGSLVSRDVRLETVSARVQGTVRGPSGPLAGVDVRVLQGGSDDLVPVTSARTDSAGRYEVQVDAGRYVLAFEDPSGDHRGEYLAGASTWASATRVVVADGATLTGRDVTLAANPRLGGRVQTTSGAGVGDAVVRLVRPLDASGAGGDVVAETTTDGTGAYGLAAPAGTYTVEVVLDGDVRWTLSSLALATGTTTRTVTLADQRAVTGRLAGPDARPAAGVEVRAWRYDPRDDTAVVVGRAVSGTDGRYALAVPPGVYRVGFHGLPLGYATTFAGGPDLGTARVVRVASTDVADVDATLAAATGVTGSISDAAVLADAPPELEAIFLRFDTDAGRWVEQERTTPGYGAYQVELPPGRYRVRVVERQEPFRTTHHGGGAAFSSAADVEVVAGSLTPGVDVVVGSELGTLRPVAAPTVTGRAVVGGTLTADPGTWTPAATDVAYQWLRDGTPVTGATGRSYVPGAVDVGRAVAVRVVASRAGYRSALAVSTPATVAPGTLVSTSPPVLTSDPVVGTRTTASSGTWSPADVTFARQWLRDGVVVDGATGSEHVPTAADVGHALALRVTASAPGYTSLTVVSQPRTVTDPPLTATTPPVITGDATTGSTLGSTEPVWSRTPGTTTRQWLRDGRPVDGATGTTYRLGLDDVGSAVALQVVGRVDGQQPVTTTSAARTVAPAALTARTAPTVTGTARPGSTLTASPGTWDAGDPTTGATSFGYQWLRSGRAVAGATKPTYRAGTADLGRPLTVRVTATRPGHATASRTSASRTVKAQPTLAVTSTGGRGTATFTVVVRAAGATPTGTVRVRLGSRTLRSATLTTYRGARRAVVTVTRQAKGARTYTVEYRGDAKVEARSTHRRVTVR
>NZ_CP011502.1|WP_083516151.1|82979_85127_+|AAA-family-ATPase
MGSSQNDPREPRRGVSSEQQAAAEIAAEQAYVDVVYGRLDESTKVAQSLVTEGFARGHVGNEGGLVERDAMVFQATRRLSALNAAHDGLVFGRLDLQGGEARYIGRIGVRDAEREILLVDWRAPAAALFYQATAQDPTGVVRRRVLRSSGKTVVGVEDDLLDAENAPEDMVVVGEGALLASLSRARDSTMHSVVATIQKEQDEAIRAPSRGATIIGGGPGTGKTVVALHRAAYLLYTDRRRFESGGVLVVGPSSVFMSYIERVLPSLGETAVTLRSLGEVVDGVGAREHDEPVAAAAKGSSRMLPVLRRLATSPQPGEPTSFRYFYKDDVLVLDAKKLANIRRGLLSNLPRNRAYPKAPAAVARALWQQVSGERALEKGEEGFLDELTTDHRYVDFVEAWWPPVDAVELWRTLPKRVGELANGAFSREELDAMVTSWSSGVPAIEDVPLIDELRYLLGEVPPDDERDDDVPRQLMSFERREREVENELRSTTSIDDDGYAHVLVDEAQDLSPMQWRMLGRRGRYASWTIVGDLAQSSWPHADEAEQARVAALEGKVEHRFRLSTNYRNSAEIYDLAADVAQVAIPGADLAEAVRRTGEAPRHEWVADAALLDAVEAEADTMLERVEGTVAVVAARADLPRLRARLADRLAAHDRLRVLDGLDTKGLEFDAVVVVEPDAIIAESEAGWRTFYVVLTRATQLLTTVGTTQTWLSRVS
>NZ_CP011502.1|WP_067853137.1|85273_86881_+|metallophosphoesterase
MRKIAVGLVLLAAAVLTGLPVATSTFLHSERHLTIGAHQAVVSPQVDGHATIDFGPLLPEVRVPVDAPLGVGVNVRLGDSDAVGLEELLQRDAAIAAQPSGEVREVTAAVTDMAAEAALRGLGVGVLTVTVLVLGWRAVGADRRRRIRREMVQPSRGQVAGGVATVVVVVGALVLVSLPERQDAEPAQTWTAAREVFPELPADPVLDRLQLAQGSATTSSRALVEGALYLYRDSVSFYGALEEQATQVRVREPEDGETTALVVTDRHDNIGMDPVARNIADRAKARLLIDLGDDTSQGGAWETFSINSLARAFKGFDVVSIGGNHDSRRTTKDQEKAGFTVLDGDPVEVDGVRFLGDTDPRGTTLTGYTEDAKTRDTALDDQDEELTSTACDADERGERVGVLAVHSWASGRKVAASGCVDLVLTGHLHYQVGPRAIAGPDGRSTTRLTTGTTGGAVLPIALGSSLRRDAQVTIVTFDADGAPVGLQVVTFTPAGVIDVGDYTELPLTSSPSPADPDPTEDPTAEDQDPEAPVQP
>NZ_CP011502.1|WP_067853140.1|86877_87822_+|hypothetical-protein
MIQVPAAVAAFARRGPRWAAFVDALPRTVDDLLAEWSLRVTGDPVHGEVALVLPVLTERGVEAVLKVGHVDEESRHEHLTLTTWDGRGAVRLLRADPARGALLLERAGPTALSSLPVLDACEVVAGLYATLHVTAPRRLVPLSTLVVRWTEQLAAAQDVVPAPRRLVQQAVSLGRAFASDPGTDGLTIHADLHDANVLASRRAEGSGGDGTPWLVIDPKGISGDPAYEPAPLLWNRWDEVASARDVRFAVRRRFHTVVDVAGLDEHRVRDWVVVRMMLNALWTLQDAQEAGRPLDDADRSWTTRCVTIAKAVQD

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Crispr_ID: NZ_CP011502_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_2

111925-112009

Orphan

Consensus_repeat	Method
GTTTGCGTGGGGCCCCACGCAAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011502_2

>merge|NZ_CP011502|2|111925-112009|CRISPRCasFinder
GTTTGCGTGGGGCCCCACGCAAACGCGCAGTTCGGGCGCATGGTTGCGGTGGGGGGAGCCTGTTTGCGTGGGGCCCCACGCAAAC

>NZ_CP011502|2|2|111925-112009|CRISPRCasFinder
GTTTGCGTGGGGCCCCACGCAAAC	GCGCAGTTCGGGCGCATGGTTGCGGTGGGGGGAGCCT
GTTTGCGTGGGGCCCCACGCAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067853216.1\|116969_117872_+\|urate-oxidase	unknown	unknown	gnl\|CDD\|274554
NZ_CP011502.1\|WP_067853205.1\|113459_114554_+\|acetamidase/formamidase-family-protein	unknown	unknown	gnl\|CDD\|225279
NZ_CP011502.1\|WP_083516153.1\|106435_108283_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP011502.1\|WP_067853202.1\|112682_113375_-\|DUF1275-domain-containing-protein	unknown	unknown	gnl\|CDD\|377734
NZ_CP011502.1\|WP_067853198.1\|110528_111896_+\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NZ_CP011502.1\|WP_067853181.1\|103493_103877_-\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377198
NZ_CP011502.1\|WP_067853178.1\|102094_102973_-\|fructosamine-kinase-family-protein	unknown	unknown	gnl\|CDD\|225547
NZ_CP011502.1\|WP_144433611.1\|102983_103490_-\|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|319971
NZ_CP011502.1\|WP_067853208.1\|114550_116077_+\|DUF3225-domain-containing-protein	unknown	unknown	gnl\|CDD\|181375
NZ_CP011502.1\|WP_067853211.1\|116173_116665_+\|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline-decarboxylase	unknown	unknown	gnl\|CDD\|188295
NZ_CP011502.1\|WP_144433847.1\|119355_120531_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|223153
NZ_CP011502.1\|WP_067853193.1\|108342_109503_+\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NZ_CP011502.1\|WP_067853186.1\|104979_106050_+\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|179559
NZ_CP011502.1\|WP_067861147.1\|117943_119281_+\|allantoinase-AllB	unknown	unknown	gnl\|CDD\|238640
NZ_CP011502.1\|WP_067853195.1\|109499_110516_+\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NZ_CP011502.1\|WP_067861146.1\|112036_112672_-\|DUF1684-domain-containing-protein	unknown	unknown	gnl\|CDD\|377941
NZ_CP011502.1\|WP_067853183.1\|103936_104902_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP011502.1\|WP_067853222.1\|120527_121802_+\|allantoate-amidohydrolase	unknown	unknown	gnl\|CDD\|236456
NZ_CP011502.1\|WP_067853175.1\|101337_102030_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP011502.1\|WP_067853213.1\|116661_116967_+\|hydroxyisourate-hydrolase	unknown	unknown	gnl\|CDD\|376352

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067853216.1\|116969_117872_+\|urate-oxidase	gnl\|CDD\|274554	TIGR03383, Structure_Of_Uricase, urate oxidase. Members of this protein family are urate oxidase, also called uricase. This protein contains two copies of the domain described by the uricase model pfam01014. In animals, this enzyme has been lost from primates and birds. [Central intermediary metabolism, Other].	2.41386e-159
NZ_CP011502.1\|WP_067853205.1\|113459_114554_+\|acetamidase/formamidase-family-protein	gnl\|CDD\|225279	COG2421, COG2421, Predicted acetamidase/formamidase [Energy production and conversion].	1.48526e-56
NZ_CP011502.1\|WP_083516153.1\|106435_108283_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	3.4773e-65
NZ_CP011502.1\|WP_067853202.1\|112682_113375_-\|DUF1275-domain-containing-protein	gnl\|CDD\|377734	pfam06912, DUF1275, Protein of unknown function (DUF1275). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although most members have 6 TM regions, and may be putative permeases.	6.41532e-24
NZ_CP011502.1\|WP_067853198.1\|110528_111896_+\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	1.81041e-147
NZ_CP011502.1\|WP_067853181.1\|103493_103877_-\|phage-holin-family-protein	gnl\|CDD\|377198	pfam04020, Phage_holin_4_2, Mycobacterial 4 TMS phage holin, superfamily IV. These proteins are predicted transmembrane proteins with probably four transmembrane spans. The 1.E.40 is represented by the mycobacterial 4 phage holin, but it also contains many cyanobacterial. proteobacterial and firmicute proteins. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as in those of the bacteriophage of these organisms. The primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded the enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases.	2.70706e-11
NZ_CP011502.1\|WP_067853178.1\|102094_102973_-\|fructosamine-kinase-family-protein	gnl\|CDD\|225547	COG3001, COG3001, Uncharacterized protein conserved in bacteria [Function unknown].	1.07059e-56
NZ_CP011502.1\|WP_144433611.1\|102983_103490_-\|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	4.58166e-59
NZ_CP011502.1\|WP_067853208.1\|114550_116077_+\|DUF3225-domain-containing-protein	gnl\|CDD\|181375	PRK08310, PRK08310, amidase; Provisional.	3.60903e-119
NZ_CP011502.1\|WP_067853211.1\|116173_116665_+\|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline-decarboxylase	gnl\|CDD\|188295	TIGR03180, UraD_2, OHCU decarboxylase. Previously thought to only proceed spontaneously, the decarboxylation of 2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) has been recently been shown to be catalyzed by this enzyme in Mus musculus. Homologs of this enzyme are found adjacent to and fused with uricase in a number of prokaryotes and are represented by this model. This model is a separate (but related) clade from that represented by TIGR3164. This model places a second homolog in streptomyces species which (are not in the vicinity of other urate catabolism associated genes) below the trusted cutoff.	2.58408e-47
NZ_CP011502.1\|WP_144433847.1\|119355_120531_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|223153	COG0075, COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism].	1.16812e-135
NZ_CP011502.1\|WP_067853193.1\|108342_109503_+\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	5.29338e-166
NZ_CP011502.1\|WP_067853186.1\|104979_106050_+\|histidinol-phosphate-transaminase	gnl\|CDD\|179559	PRK03321, PRK03321, putative aminotransferase; Provisional.	2.30264e-157
NZ_CP011502.1\|WP_067861147.1\|117943_119281_+\|allantoinase-AllB	gnl\|CDD\|238640	cd01315, L-HYD_ALN, L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in biotechnology). But L-HYDs differ by having an L-enantio specificity and by lacking activity on possible natural substrates such as dihydropyrimidines. Allantoinase catalyzes the hydrolytic cleavage of the five-member ring of allantoin (5-ureidohydantoin) to form allantoic acid.	0
NZ_CP011502.1\|WP_067853195.1\|109499_110516_+\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	1.66413e-146
NZ_CP011502.1\|WP_067861146.1\|112036_112672_-\|DUF1684-domain-containing-protein	gnl\|CDD\|377941	pfam07920, DUF1684, Protein of unknown function (DUF1684). The sequences featured in this family are found in hypothetical archaeal and bacterial proteins of unknown function. The region in question is approximately 200 amino acids long.	6.25623e-42
NZ_CP011502.1\|WP_067853183.1\|103936_104902_-\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	3.49934e-20
NZ_CP011502.1\|WP_067853222.1\|120527_121802_+\|allantoate-amidohydrolase	gnl\|CDD\|236456	PRK09290, PRK09290, allantoate amidohydrolase; Reviewed.	2.27388e-148
NZ_CP011502.1\|WP_067853175.1\|101337_102030_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.06703e-86
NZ_CP011502.1\|WP_067853213.1\|116661_116967_+\|hydroxyisourate-hydrolase	gnl\|CDD\|376352	pfam00576, Transthyretin, HIUase/Transthyretin family. This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyze the conversion of 5-hydroxyisourate (HIU) to OHCU. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.	1.65434e-38

>NZ_CP011502.1|WP_067853198.1|110528_111896_+|2-oxo-acid-dehydrogenase-subunit-E2
MSEFRLPDVGEGLTEAEVLTWHVAVGDVVEVNQTIVDIETAKSVVELPSPFAGEVTALLVPEGTTVPVGTPIIAIGGPTGPVVPDDASSLVEADEPADDEGPADPSAGEKREPVLVGYGVRTASTRRRRRKGDASVQAAEPSGGVTTLERPTESEPRPRDVRALAKPPVRKLAKDHGVDLLDVPCDGPVVTRADVEAFIAGRRPTVAAPAAAPVRSVEGDTRIPVKGVRKATAQAMVSSAFSAPHVTEWVTLDVSATMELVERLKADRRFAGVKVSPTLVVAKAVCLALSRTPELNASWDEAAQEIVLKGSVNLGVAAATDRGLVVPNIPGADRMSLLELGEALADLTATARAGRTQPAQMSGGTFTITNVGVFGVDAGTPILNPGETGILCVGQIDRRPWVVGPDAGGAERIEPRWVTTLAVSFDHRVVDGQQGSRFLADVASILRDPALALTF
>NZ_CP011502.1|WP_067853195.1|109499_110516_+|alpha-ketoacid-dehydrogenase-subunit-beta
MSTSASTATSERTSAVGQRLSLGKAINAGLRAAMEADPKVVVMGEDVGPLGGVFRVTEGLQKDFGDDRVIDTPLGESGIVGAAVGMMLRGYRPVVEIQFDGFVYPAYDQIVSQVAKLHARSQGVVRMPAVIRIPFGGGIGAVEHHSESPEAQFCLTAGLRVVSPSNAHDAYWMIQQAIASDDPVVFMEPKRRYWDAGPVGQESTPLHASQVVRDGRHATLLAYGPMVRTCLESAEAAAEDGVDLEVIDLRTLSPLDLGPVHESVRRTGRAVVVHEASRTLGLGAEIAARVQEECFYSLEAPVLRVTGYDLPYPPSRVEEEFLPDLDRVLDAVDRAMAF
>NZ_CP011502.1|WP_067853193.1|108342_109503_+|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MTVPVHTPGPETVRPVTTPATVDTELVQLLTPEGRRVEHERYAFDGDDESIRSLYRDLLLVRRIDHEAHALQRHGELGLWAQCLGQEAAQVGSGRALRTQDFAFPTYREHGVAWCRGIDPARLLGLFRGVELGGWDPAETGMALYSIIIGAQTMHATGYAMALQRDGAVGTGDPARDAAALAYFGDGASSQGDVHEAFVWASSFNAPVVFFCQNNHWAISVPLARQSRTPLVQRAAGYGFGGVRVDGNDVLAVHAVTQAALQRARDGEGPTLVEAVTYRMGAHTTSDDPTRYRDTAEVEAWRHRDPLARVERHLRELDTPESFFTDLQTEADDLGAHLREACRSLPEPDLGALFDGVYADAHPELAAQKAEYLAYRDSFDTEGGAA
>NZ_CP011502.1|WP_083516153.1|106435_108283_-|FAD-dependent-oxidoreductase
MACSGGADVLVGGVTAVTPVVTVAGRRDDAKCAASYTGSVDHPVIVLASDEHASHLDDEFRRYHRDYDVRVVRTCADATALLERLCAADRQIALLVQDAGLPDADVWTSFAAWRRVVPTARRLVTVPWERFLEEGARLRPGLAHGKFDAFLLMPRGLRDEEFHAAVVELLSDWGSTVARPEVETIRLVSRPGNPLTAAVRDFAHRMGIPAGVHHPDSDVGREILAELATTRQESGTAEAPGEPVVASVYRAPFVATSVREVAQALNGSSGETVLTDVVDVAVVGAGPAGLATAVYAASEGLSTVVLEAEAVGGQAGTSSMIRNYLGFPRGVSGMRLAQRARNQAVRFGARFLTGWEVDALQPCDASLAHDEREHVLTTPGGGHVRARSVVIATGVAYRHLGVASVEELVGRGVYYGSAMTAAPEVEGQPVVVVGGGNSAGQAAIHLARFASSVTIVVRRDLTETMSQYLIDELRWNERVHVRVGVEVVDGGGAGLLEWLDLRTNASGEVERVPAAGLFLLLGARPTCGWLPPTVARDPRGFVLTGRDVPKEAWLGPGGVPGPWASDAIVPPDTLATTAPGVFAVGDIRSGSMKRVASASGEGASVVPLIHAWLAP
>NZ_CP011502.1|WP_067853186.1|104979_106050_+|histidinol-phosphate-transaminase
MTVPSPRPVFDAIPGYKAGRPAEHDELKLSSNENPFPPLPGVVERAAAELARINRYPDAGVARLHAALSRHLSRPEDTFAAGTGSVAVLFSLLDAYCGPGDEVVTAWRSFEAYPIAVTVTGATHVTVPLRADHTHDLDAMAAAVTDRTRVVVVCTPNNPTGPVVRHDELERFVAALPSSVLVVVDEAYVEFVRDPDAARGLDLQARFDNVLVLRTFSKAYGLAGLRVGYLVGHPDVAAAVRKATPPFSVSDVAQAAAVASLDAADELAARVEEVVQGRALLLEGLRAQGWTLPDSQANFVWLPSDQGPQLAEAFWPVAVRPFPGAVADGGGVRVSVGTTSANERLLDVAARHLTGR
>NZ_CP011502.1|WP_067853183.1|103936_104902_-|EamA-family-transporter
MSLSEQRVVRSPLVGYALVLTAAVLFGLNAGASRIPLRSGTDEATFTTVRITAALVVLVVVALVVDRRALRLPTLRRLPLLLGLGVLGIAGLQGFYNVAINRLPLGIALLLEYTGPVLVVLWVRFARRRPVHARMWPALGLTLAGLAVVSQVWSGLAFDGLGVAAALLAAVCFASYFLLGEDDGVSADPLHHIVWAFALAAVLMNVVAPVWRADALGADASMLGRLDDLTVPAWAAMAWIVLLGTVTPFFLLLLALRALPATVVSVVAMLEPVVASLVGWGWYAESLTAVQLGGVAMVLLGIVLAQTARRDPHPDELPPLT
>NZ_CP011502.1|WP_067853181.1|103493_103877_-|phage-holin-family-protein
MLSRLLTSWVLGAAALATAAWLLGTHMSIGTATDTTSERLITLAVVAAIFAVVNTFVAPVIKLLSLPFIILTLGLLLVVINAVLLLLTSRIADALNAPFFIDGFGWAVLASIVISVVNAVLGSFAED
>NZ_CP011502.1|WP_144433611.1|102983_103490_-|low-molecular-weight-phosphotyrosine-protein-phosphatase
MADAPLRLEVTCLGNICRSPMAHVVLEQRLADAGLADDVVVTSSGTGGWHEGEAMDERAAAALRDAGYDPSRHRARTFTRDTYAETDLMLAMDASNLADMTDLAPTVADAGRVRMFRSFDPEATEGDEEVDDPWYGGPEGFQRVLAVVERTSDAIVAAVPRLRAEATG
>NZ_CP011502.1|WP_067853178.1|102094_102973_-|fructosamine-kinase-family-protein
MARMTGTAARAEALIGHGVVATTPVAGGDICTTTRLRLSDGRVAVIKTRPQAPAGFFAREAAGLRWLAEVEGGAKVPELLGADDDCVVLAWVEPGKPTVEAAERFGQALARTHAAGAPTFGADVDGYIGLAPLPNRPLETWPEFYASRRVMPYVRAAVQRRALTAEQAATIERTMSRIHDVAGPAEPPARIHGDLWSGNVVWGTDGDAWLIDPAAHGGHRETDLAMLALFGLPHLQRVLESYDDAAPLADGWRGRVPLHQLHPLLVHAVLFGGTYGARAAAAAKAALEPPAD
>NZ_CP011502.1|WP_067853175.1|101337_102030_-|response-regulator-transcription-factor
MRILVVDDDRAVRDSLRRSLEFNGYTVELASDGAEALAVVPRTDPDIIVMDVMMPRLDGLEATRALRSAGNDVPILVLTARDAVSDRVDGLDAGADDYLTKPFALDELLARVRALMRRSARQAALEADEQPLEFADLTLDPVTRDVTRGGRAISLTRTEFALLELFMQRPKRVLERSFILEEVWGFDFPTTANSLEVYVGYVRRKLEAEGEPRLLHTVRGVGYVLRETPP
>NZ_CP011502.1|WP_067861146.1|112036_112672_-|DUF1684-domain-containing-protein
MLLTLVDWRVRVAALYEQVRADPDPERGHATWRQGRDELFRNHPQSPLPARDPLRETGLPYWPYDPAWRFELPLLPAPTDAWDPDERVVDGGGDGDVTMLRTGQLALPSGSTLDVWTLQQYAGGIFVPLRDATSGRADGAASYGAGRYLLDTAKGSWLGGRPTPQGGHTVVLDLNFAYHPSCRYDDRWRCPLASPGNTITDVVEAGERLPA
>NZ_CP011502.1|WP_067853202.1|112682_113375_-|DUF1275-domain-containing-protein
MLRRITSDRMNLVLMLALTFSTGVIDAVGYLGLDRVFTGNMTGNVVILGMAVVGADDLPILGPALALVGFLAGAALGGRVLKGARTGWSARTTTLIACVGASILALGVVLFVVGDDVGHAGQVVITTLLGAAMGLQAATARFIAVKDVTTVVVTSTITGLAADSVLGNGKGGGSGRRVAAVVLILAGAAAGALLLRWHLGAGLLLAAAVTLVVCLVGALHARAAVPASAP
>NZ_CP011502.1|WP_067853205.1|113459_114554_+|acetamidase/formamidase-family-protein
MTTRQGLPRSTPLDSAPLHTGTGVPSDATYLPSTGDHVLWGRLPCATDRAVLSVEPGEEVVVDTISHEGILEDQGRDPRAFFEPHGVDVLDDAVALAASGYARTFGVDGPHVVTGPIEVRGARPGDLLAMTLVDAQQRVPYGVVSNRHGRGALPGEYPLDGDVFSVFARAEGDTGVMTYGPQDERTVRFPLAPFLGIMGVAVAGDERPHTVPPGAHGGNLDINLLTAGATLYLPVQVAGALAYVGDPHFAQGGGEVALTAMEASLRATVRLDVVPREEAVAQFGELVGPLARTREYLVPTGLDPDLDVATQNCVRAAIGLLQARYGMDPRHAYAYLSAATDFDISQVVDVVKGVHARIRLADFA
>NZ_CP011502.1|WP_067853208.1|114550_116077_+|DUF3225-domain-containing-protein
MSDDAPEGLLEAFWAYETALMSDDLETLDALFADRPDTLRGDAAGVLVGHETISRFRGSRGGAPRRTIAEVHVRVVDATHALVVAVTAPERGGRGQQTQLWERTEVGWQVTAAHVAVPAPAVDTRVWRAVGDPLVRPGTGPLSGESVAVKDLFAVAGQPVGAGNPTWAANAPVESSHAWAVQTLLGAGASVRGIARTDEFAYSLAGTNAHFGTPPNAQAPGRISGGSSSGSASAVALGHATIGLGTDTGGSIRVPAAYQGLYGMRPTHGSVPTAGLMPLAPSFDTVGWMTRDAGLLRRVGSVLLPAAAPRPLRDVVVVPELLALASPDVRAAVEGFLGAGPRGGTGWGGDGGTVVEESWDLPETWPEVFRVHQAAQAWQSHGWWLRTRLDSLGADVRSRFEAAAEIDHDTAVQAADDAARARDAVRRLVGDRVVVLPSAPTVAPELGADLGEVRAATLRLTCVAGLGGLPAVSVPLTTSDGLPCGVCLVGPPRRDLDLLDLVTGPLHA
>NZ_CP011502.1|WP_067853211.1|116173_116665_+|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline-decarboxylase
MDITTFDTADAEKAAAVLRACADVGAWVDALVAGRPYGSVEALVARADALAAGWTGAQVEAALADHPRIGERHVGTGRSAELSGREQSGVDASVDTAARLAAGNAAYEERFDRIFLVRAAGRSAEEILALLEQRLTHDPETELAVTAGQLREIALLRLEDTFA
>NZ_CP011502.1|WP_067853213.1|116661_116967_+|hydroxyisourate-hydrolase
MTTLSTHVLDAALGRPAAGLVVSLDDSVTATTDADGRIRFDDPVDLGVHELVFATGPWFADQDRSTFYPVVRVAFEAGTGQEHHHVALLLSPFAYTTYRGS
>NZ_CP011502.1|WP_067853216.1|116969_117872_+|urate-oxidase
MATGDIVLGPNQYGKAENRLVRITRDTDRHEIEDLNVTSQLRGDFVACHVEGDNSQVVATDTQKNTVYAFAQQHGIGSPEQFLLTLGEHFVTSFDWVCGGRWEAELYAWERIAVDGRPHDHSFVRTGREVRTTVVQKDGDQTWVLAGFKDATVLKSTGSEFHGFPRDRYTTLRETTDRILATSVTAWWRYTSTDVDWNARYEAIKAVLLETFASVHSLALQQTIFAMGRAVLEQFDDVAEIRLSCPNKHHFLVDLEPFGLDNPNEVFFAADRPYGLIQATVQREGAPQAPQAWATVPGFC
>NZ_CP011502.1|WP_067861147.1|117943_119281_+|allantoinase-AllB
MRLDAIQAQQVLVNGQFRPATLTLDDGRVTAVGPLDDVPAGEVHRVPDTAYVVPGVVDTHVHVNEPGRTEWEGFSSATRAAVLGGVTTLVDMPLNSVPPTTTLEGLAAKRAAAQGQLAVDVGFWGGAVPGNVADLEPLWDAGVFGFKCFLSPSGVEEFPPLDRAEFDAALAEVARLDALMIVHAEDAAILDSTPAPGSRAYRDFVLSRPDASEVSAIRQVVDGARETGARVHVLHLSSARAIDLIADARAEGLPLTVETCPHYLTFSAETIPDAAPEFKCCPPIRDAGNREALWQALQEGLVDCIVSDHSPSTVEEKLKGDGDLQQAWGGVSGLQVGFAVLAHEARLRGIPLERLSRWMSTSTADLVGLSRKGRIAVGADADLAVYDPAVELHVEAARLAHRNPISAYDGLRLAGRVVSTVVRGELVDVDQVYHRHGRQLERPSS
>NZ_CP011502.1|WP_144433847.1|119355_120531_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MGPGPITADPRVLRAMSAQLVGQYDPAMTGYMVEVMGLYREVFATANEQTFLVDGTSRAGIEAALVSLLEPGDRVLVPVFGRFGHLLAEIGERCGAEVHTIETDWGTVFAPEQVEAAIVEVRPKVLAVVQGDTSTTMCQPLADLGEICRRHDVLLYCDATASLGGNPFETDAWGIDVATASLQKCLGGPSGSSPITISPRAVDVIDGRRHVEAGIAEERDVARGVRIASNYLDLAMIMDYWGPRRLNHHTEATTMLYGARECARLLVEEGMDAAVERHRLHGAAMLAGVRGLGLEVFGDVDHKMSNVVAVHIPDGVDGDAARAVMLEDFGIEIGTSFGPLHGKVWRIGTMGYNARKDAVLVTLAALEQVLRSGGVAVTAGGGVGAAQEVYA
>NZ_CP011502.1|WP_067853222.1|120527_121802_+|allantoate-amidohydrolase
MSAPTDLPTSGAAVGSAAEVLARCAELDLYSSHPEHLERVYLSPEHAAVNRVVARWMTRAGLAPRQDAAGNQYGRREGREPGLPALLLGSHLDTVPDAGSYDGMLGVLMGIAVAERLGDRVDDLPFALEVVGFSDEEGTRFGKALLGSCAAAGTWDPAWWDLCDAGGMTLRTAFEEFGLDPRAVGTAARRPDELVGYLEAHIEQGPYLEEADASLGYVTTIAGARRFVLEVEGEARHAGGTPYDRRKDAMVGAAECITAIERMVRPSGCIATTGRIEARPGAVNVIAGHVEVSLDLRAPTDAARDAMWEDLEAELQRLCAARGLGLRVTETHRAPAMPCAPWLTDAVVSGIVGTGDTTPMGLWSRAGHDGMAVGAVTDVAMLFVRCHDGVSHHPDEDVREIDVARGLDAFEAAVLEVAAKVAAS

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Crispr_ID: NZ_CP011502_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_3

131433-131521

Orphan

Consensus_repeat	Method
GTTTGCGTGGGGCCCCACGCAAACGTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011502_3

>merge|NZ_CP011502|3|131433-131521|CRISPRCasFinder
GTTTGCGTGGGGCCCCACGCAAACGTGCGGTTCGGGCCGATGTTTGCGGTGGGGGGAGCTGGTTTGGGTGGGGCCCCACGCAAACGTGC

>NZ_CP011502|3|3|131433-131521|CRISPRCasFinder
GTTTGCGTGGGGCCCCACGCAAACGTGC	GGTTCGGGCCGATGTTTGCGGTGGGGGGAGCTG
GTTTGGGTGGGGCCCCACGCAAACGTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067853244.1\|129816_130617_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223673
NZ_CP011502.1\|WP_067853265.1\|136146_136557_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP011502.1\|WP_067853230.1\|123493_126283_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|376913
NZ_CP011502.1\|WP_067853239.1\|127914_128982_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|378117
NZ_CP011502.1\|WP_067853262.1\|135505_136021_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853233.1\|126295_127207_-\|XdhC-family-protein	unknown	unknown	gnl\|CDD\|224886
NZ_CP011502.1\|WP_144433849.1\|129025_129817_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213260
NZ_CP011502.1\|WP_067853222.1\|120527_121802_+\|allantoate-amidohydrolase	unknown	unknown	gnl\|CDD\|236456
NZ_CP011502.1\|WP_144433612.1\|130613_131405_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223673
NZ_CP011502.1\|WP_067853253.1\|132917_133844_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235737
NZ_CP011502.1\|WP_067853256.1\|133896_134700_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|316740
NZ_CP011502.1\|WP_067853236.1\|127315_127792_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|238612
NZ_CP011502.1\|WP_083516157.1\|136546_136789_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176115
NZ_CP011502.1\|WP_067853276.1\|140130_141045_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP011502.1\|WP_067853250.1\|131550_132846_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|349949
NZ_CP011502.1\|WP_144433848.1\|122672_123497_+\|FAD-binding-molybdopterin-dehydrogenase	unknown	unknown	gnl\|CDD\|224238
NZ_CP011502.1\|WP_067853225.1\|121798_122662_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP011502.1\|WP_067853273.1\|137110_138988_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173842
NZ_CP011502.1\|WP_067853259.1\|134710_135505_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_CP011502.1\|WP_067861149.1\|139148_139721_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067853244.1\|129816_130617_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	4.79001e-26
NZ_CP011502.1\|WP_067853265.1\|136146_136557_+\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	2.88209e-06
NZ_CP011502.1\|WP_067853230.1\|123493_126283_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|376913	pfam02738, Ald_Xan_dh_C2, Molybdopterin-binding domain of aldehyde dehydrogenase.	6.50043e-160
NZ_CP011502.1\|WP_067853239.1\|127914_128982_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|378117	pfam09084, NMT1, NMT1/THI5 like. This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.	1.07541e-39
NZ_CP011502.1\|WP_067853233.1\|126295_127207_-\|XdhC-family-protein	gnl\|CDD\|224886	COG1975, XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones].	2.45914e-46
NZ_CP011502.1\|WP_144433849.1\|129025_129817_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213260	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters. NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	4.63903e-105
NZ_CP011502.1\|WP_067853222.1\|120527_121802_+\|allantoate-amidohydrolase	gnl\|CDD\|236456	PRK09290, PRK09290, allantoate amidohydrolase; Reviewed.	2.27388e-148
NZ_CP011502.1\|WP_144433612.1\|130613_131405_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	1.41713e-34
NZ_CP011502.1\|WP_067853253.1\|132917_133844_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235737	PRK06197, PRK06197, short chain dehydrogenase; Provisional.	8.46559e-108
NZ_CP011502.1\|WP_067853256.1\|133896_134700_+\|hypothetical-protein	gnl\|CDD\|316740	pfam14247, DUF4344, Putative metallopeptidase. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 247 and 291 amino acids in length. There is a conserved EED sequence motif. This is a putative metallopeptidase.	3.64724e-50
NZ_CP011502.1\|WP_067853236.1\|127315_127792_+\|nucleoside-deaminase	gnl\|CDD\|238612	cd01285, nucleoside_deaminase, Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on the substrate. The functional enzyme is a homodimer. Cytosine deaminase catalyzes the deamination of cytosine to uracil and ammonia and is a member of the pyrimidine salvage pathway. Cytosine deaminase is found in bacteria and fungi but is not present in mammals; for this reason, the enzyme is currently of interest for antimicrobial drug design and gene therapy applications against tumors. Some members of this family are tRNA-specific adenosine deaminases that generate inosine at the first position of their anticodon (position 34) of specific tRNAs; this modification is thought to enlarge the codon recognition capacity during protein synthesis. Other members of the family are guanine deaminases which deaminate guanine to xanthine as part of the utilization of guanine as a nitrogen source.	4.59276e-45
NZ_CP011502.1\|WP_083516157.1\|136546_136789_-\|hypothetical-protein	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.80259e-05
NZ_CP011502.1\|WP_067853276.1\|140130_141045_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.73822e-37
NZ_CP011502.1\|WP_067853250.1\|131550_132846_+\|MFS-transporter	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	1.35055e-26
NZ_CP011502.1\|WP_144433848.1\|122672_123497_+\|FAD-binding-molybdopterin-dehydrogenase	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	1.37755e-16
NZ_CP011502.1\|WP_067853225.1\|121798_122662_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	1.35398e-40
NZ_CP011502.1\|WP_067853273.1\|137110_138988_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	4.93846e-180
NZ_CP011502.1\|WP_067853259.1\|134710_135505_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	7.33748e-13
NZ_CP011502.1\|WP_067861149.1\|139148_139721_-\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	1.33461e-19

>NZ_CP011502.1|WP_144433612.1|130613_131405_+|ABC-transporter-permease-subunit
MRVLAVARPLLTILVVLAATIGAWYALVTLTGVSDLTTRLPQDVIAYLFTEDDAAANRAEVLGALGQTVIDAGIGFVAGLSAAFVLATVMVLWSGVEAATMPVVMIVRTVPLVALAPIITLLFGNGFWCVAVMSGIVVLFPALVNIAYGLRSVTPQMHDVVTVYGGSSWDVMRRVAFPTALPSIFAAIRISVPGAITGALIAEYFTTTDSVGKAVNQALALYQYDKLWSLVVVVTLVSVIGYALAQLAETFVLARYGRNAGRA
>NZ_CP011502.1|WP_067853244.1|129816_130617_+|ABC-transporter-permease-subunit
MSTLSLSPERTKTLGIGAAGLVGTVALWWLVAATVLARFQVPTPGEVLSTFADRGFDYYRTVFSITLEESLYGYLVGVALALTVAVLVLLVPFIEPIVMQLAVITYCLPIVVLAPILITVHEIPEKGGLSATAIDLAAVSVFFTTVVGAVLGFRAADQATLDVVEVYGGSRLQQLLRVRVVAALPALFTTLQIAAPAAFLGALLGEYFDRHLEIGVGPSLILSQNNRETALAWSLGIGCALVSGLAYALLGLLGRVVAPWSRGAAS
>NZ_CP011502.1|WP_144433849.1|129025_129817_+|ATP-binding-cassette-domain-containing-protein
MTVPTAGTGLHIQDLSKTFSVGRKEVVALTDATLHTDKGSFLSLLGPSGCGKSTILRILAGLEKPTSGRATVDGKSPTELRRDHELGIAFQDSALLPWRSVESNIRLPFQVSGEQPDDALVKELIALVGLEGFEKAKPAQLSGGMRQRVSIARSLVVKPSVLLLDEPFGALDDMTRQRLNVELLRIWTEKPATTLMVTHGISEAIFLSDQVAVMSPRPGRIKEVIDVDLPRPRVPEMMRTPEFHALHDQASELLFGAGGAAVE
>NZ_CP011502.1|WP_067853239.1|127914_128982_+|ABC-transporter-substrate-binding-protein
MNQSIRRGTTARVAAVLSAAALALSACGSSSDSADESSGDGLGDVTVQFSWIKNAEFAGEFIADSAGYYKDAGLGKATFLAGPVAQEEIVATGKADFGLSNAVSTASAITNSDFPLKIIGATYQKNPFSILSLADQGNIKTPQDLIGKKIGVQDPNLSLFKAFLAANDIDEKDVEIVPNGFDVAPLEDKQIDGLVAYVTNESLLVKSHGFDTVDLSFADNNLPFVAESIITTDETLKKKPDYVKAFLEAEIKGWKDACDGEAGYEKGAKLAVDTYGKDIDPPLELDKEIAQAKQQCELLVNTDETAKNGIFTISDDLVQANLTSLKAAGIDISADDLFDLEPLNELLKEKPELVQ
>NZ_CP011502.1|WP_067853236.1|127315_127792_+|nucleoside-deaminase
MSDEQDATWLALAVDLATQNVAEGGGPFGAVLVKGDELVATGQNRVTRDLDPSAHAEVVAIRAACRAIGDFSLAGLTLYSSCEPCPMCLATSLWSRVDRVVFAADRDDAARGGFDDREFYELFSRDRATWGTTVQATRTADASSPFDAWLSHAARTAY
>NZ_CP011502.1|WP_067853233.1|126295_127207_-|XdhC-family-protein
MLDIAPTLRTWTTEGRRVAVATLVAVHGSAPRAVGAAMAVDDTGRVVGSISGGCVEGALVAECEEVLAGGPTRRRTYSAGDWLEPGLMCGGTIEVLVCDLASLDAEQWHQVECAAGGRSATLTLAGTSISVQRPPKLVVVGAVEFAVALCALASRAGFAVTVLDHRATFATKERFPDATAVVVADLADWCATRTWSPEDAVCVLGHDLDRDTVVLASALEGGAGYVGAMGSRTTHERRVRALDGVDVSRLRSPLGLDLGGSGPEHTAVAILAEVLAVRHGGSAQPLSATTGPIHRSPARLDPA
>NZ_CP011502.1|WP_067853230.1|123493_126283_+|molybdopterin-dependent-oxidoreductase
MSSPVETGPVEAGPVERGTFEVRVNGASVTTAPTPGQCLRTYLRDHDRLDVKKGCDAGDCGACTVLVDGDPTHSCVFPAVRAAGREVTTASGLGTPDDLHPVQQRFVDAAGFQCGFCTAGMVVTASTLPEGLAHDDLCRSMKGNLCRCTGYRSVRDALAGTANVGEAPAGEAFGASVAAPAARRVVAGQEPFTLDLEAPADLLHVAVLGSPHPHARIASIDTSRAEALEGVHLVLTHHDAPDVLYSTGRHQSRLDDPDDTRMLDPVLRFAGQRVAVVVAETVATAQEACRLVDVEYEVLPAVLDPDAARRPGAPLVHGDKDPVVSRIAEPTRNVVAQLHDEHGDVEAALASAHAVVSGTWQTSRVSHAQLETHGGRGWLADDGTLVVRTSTQVPFLVRDELAHVLSLPRERVRVLAARVGGGFGGKQEMLVEDVIGLAVLRTGRPVQYELSREDQFTIVPCRHPMRVGVTLGADADGHLTALKLDVLSDTGAYGNHAVGVMFHGCHESVAQYRCPNKRVDAEAVYTHQLPSGAFRGYGLGQVMFGIESAMDDLAAELGLDPAELRRRNAVVPGDPFVVTALEEDDLEYGSYGLDQCLDLVDAALASGRGDDAPEGWPTGRGVAMAMIATIPPRGHFTDVAVAVDADGRYTVSVGTAEFGNGTTTVHVQLAATELATTPDRVRVRQSDTATSGYDTGAYGSAGSVVAGKAVHVAAERLHAELLTLAARAAGVARGHCTLERDGVRLPDGSLLSFREVVPDGLSAEGTHDGSPRSVAFNVHGFRVAVDPTSGEVRVLQSVHAADAGVVINPEQLRGQVEGGVAQAIGSALQEEVVVEDGHVVTRTFRSYRVPQMADVPTTEVLFADTHDELGPRGAKSMSEAPYNPVAPALANAITDALGARPRTLPMSRDRVWRLAQTGSDAPPSRQRRG
>NZ_CP011502.1|WP_144433848.1|122672_123497_+|FAD-binding-molybdopterin-dehydrogenase
MHTVETFRLPTGPDDLVLAPGETWLAGGTWLFSEPQVTTTGLVDLLALGWPDWELDAGAADGPTTGLTTGLTIGATCSLLDLVTHAERSGLPGLAVARPCVEALVMSSKVSRRATVGGNVCLALPAGGATSLLTGLGADAVVWGPGGERRVPVASLVTDVRRTSLDPGELVRAFEVPRASLASTTAFRRAALTPMGRSGAVLVGRREPDGGVHVSVTASTHRPHVLDLGPAPTESDVATAVSTIERWYDDPHGAPDWRAAQTLRCALEVVEELA
>NZ_CP011502.1|WP_067853225.1|121798_122662_+|MurR/RpiR-family-transcriptional-regulator
MSTTALDPSGAPREEARPIEVRITEKYADLAPQERRAADVLLEHLHDLAMYRASELADLAGVSKATMSRLFRRLDYEDFTQVRDQLLVLRNAGLPVPVGAPPSVARHLETEVEHLHRVLTAAEGAIEQAAALLAGAATVTVVGMRNSYPVALHLTQQLTQARTGVGVAPSPGQSLSDEVVGLGADDVVVVVAFRRRPPEIAALLDLVRSQGARVVLMADPSGRRLASPGDVWIECGASTQAAFDSYAAAMSVVAALSSRVLDALGPAAGQRVAAIAAAYRALGEIED
>NZ_CP011502.1|WP_067853222.1|120527_121802_+|allantoate-amidohydrolase
MSAPTDLPTSGAAVGSAAEVLARCAELDLYSSHPEHLERVYLSPEHAAVNRVVARWMTRAGLAPRQDAAGNQYGRREGREPGLPALLLGSHLDTVPDAGSYDGMLGVLMGIAVAERLGDRVDDLPFALEVVGFSDEEGTRFGKALLGSCAAAGTWDPAWWDLCDAGGMTLRTAFEEFGLDPRAVGTAARRPDELVGYLEAHIEQGPYLEEADASLGYVTTIAGARRFVLEVEGEARHAGGTPYDRRKDAMVGAAECITAIERMVRPSGCIATTGRIEARPGAVNVIAGHVEVSLDLRAPTDAARDAMWEDLEAELQRLCAARGLGLRVTETHRAPAMPCAPWLTDAVVSGIVGTGDTTPMGLWSRAGHDGMAVGAVTDVAMLFVRCHDGVSHHPDEDVREIDVARGLDAFEAAVLEVAAKVAAS
>NZ_CP011502.1|WP_067853250.1|131550_132846_+|MFS-transporter
MSATTRRGPVAVWLTGLSLYFLAVFHRSSLAVAGLAATERFGISAAQLSTFVMLQLVVYAGMQIPVGLLLDRFGPRRILTIGVVVLTLAQAAFALADTFAVALVARVFVGLGDAMTFVCVLRLVTTWFPSRRIPLVTQLTGVLGQLGALVAAVPMTWALRELGWTPTYLAAASLGLVLLVVLLVVVHDEPGSPRVLGAPLSWTTVRSSLAASWRHPGTRLGFWVHFTTQFSATTLGLLWGYPFFVRGEGRTSAQAGALLTILVLAVMVAGPVLAWAITRDPWHRSTIVLGIVGSIVAVWTVVLAWPGTAPSWLLVLLVVVVGVGGPASMVGFDLGRSFNPPDRLGAATGIINQGGFVASLLLVVAIGLVLDWRTPGASTDYAPGAFRWAMSVQYVLWAVGLTQIWRYRRRTRAQLLAEDPDAREHWRGRLA
>NZ_CP011502.1|WP_067853253.1|132917_133844_-|SDR-family-NAD(P)-dependent-oxidoreductase
MSWSTQDIPDLGGKRAVVTGVTGGLGFHTALELGRAGAGLTVTARNPQKADDTLARLREELPDVDVEVLSLDLADLADVRRATEELGSRHDRVDVLVNNAGIMIPPYSTTADGFELQIGTNHVGHFAWTAQVWPLLADDARVVSVSSLAHLQAKGIDLRSLTPEGSPRTYRRWVSYAESKLANLSFALELDRRLKSAGKAVVSTAAHPGFARTELQKTGVAMGNPFLGTVVQQVSALASQSAAAGALPSLRAATDPTFTGGEYVGPASLGGTRGAPVIAGMTRWARDEQLARDLWAATEQATGVTFEV
>NZ_CP011502.1|WP_067853256.1|133896_134700_+|hypothetical-protein
MRRIIVVATVALAALGGFTVGLLAAPGDARPEAAQGDAARGARVSVTYPDVADRWQGWQDRVRASGVLEDAARDLRATVSLPSPLVVEVTTCKDGTGYLAGEGRIELCLQDVRDSDAELEEAGADDVDATLEGIWRETFFHEAGHAVIDMLDLPFTGREEDVADQFAAWRLAEAGDDEATGALLSSAYEYQLLAAAYEADPTDEHTSDAARAVNYLCYLYGSDPDTWSGLVDDDPLTQDRADQCTDEWDRLRVGWRDLLAEAGALRS
>NZ_CP011502.1|WP_067853259.1|134710_135505_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MLQTYVDAWLASVRDTIALLEELDDAAWSTPTDLPGWTVADVAAHLAHLEAVTAGHVVDEAPTTASAGGIASVYTEAGVESRRGLTREQVLDELRRSVDVRAERLGGALPDDPTARAEHTPAGVGWTWDTMLRNRTVDVWCHEQDVRRAVDRPGNLDSAGAHVTTHTFAAAMPFVLGKKVGATAGTSVLWDLTGPIALQVGATVGDDGRARPGVPDSPTATLTLTSDAFAVLAAGRRRPGAVEVAVSGDTDLAHRVLEQMAVTF
>NZ_CP011502.1|WP_067853262.1|135505_136021_-|hypothetical-protein
MRLTSPLWYLAAFLLAIGGWMASAVVAAGAWDHVRDATLQNLTERVDAKGASLAVFTDVRQPERDVTCTATGPAKGAEPVTLEDAPIDLRVPQDGSTWYLIAFEREGSDQVAVRCTPKDRAADAATYRVAVADGFLDRTRNGAGIAWIAAAVAVALALATWWTRRKRTLED
>NZ_CP011502.1|WP_067853265.1|136146_136557_+|DoxX-family-protein
MDGVFLISRILFAYLVIGSGIGHLTATGAMAGYAESRGLSNAKVLVQVSGVALLAGGVSVLLGIWGDVGALGLAILLLVTAVLMHAFWKESDAQAKQMEMVAFNKNVALAGGALALFVLLSTDFAPYTLTGALINW
>NZ_CP011502.1|WP_083516157.1|136546_136789_-|hypothetical-protein
MSDSLDLVEDLVVAGLGVGMLPLWRRPRDGVTVVPFHDPGVTMRAHVWTRRGRATWPPLALVLERLLDAPSVSQPRVVTS
>NZ_CP011502.1|WP_067853273.1|137110_138988_-|acyl-CoA-dehydrogenase
MSHYKSNLRDVEFNLFELFGRQDVLGTGAFEELDLDTAKSILAETERLAREDLAPSFEDSDRNPPVYDPKAMTVTMNPAFAKSYKAWMDAEWWRLQVPEELGGQKAPSSLIWAIGEFVLGANPPIWMYSAGPAFARIVFENGTERDKKIAEFMTNRQWGATMVLTEPDAGSDVGAGRTKAYPNEDGSWNIEGVKRFITSAEHDMSENIMHLVLARPQGVEGVGGPGTKGLSLFLVPKIHFDHETGELTGERNGAYVTNVEKKMGIKVSTTCEVTFGDPSTGGGEPAKGWLLGEVHDGINQMFRVIENARMMVGAKAIATLSSGYLNALEYAKERVQGADLTQAADKTAPRVTITHHPDVRRSLMTQKAFAEGLRSLVFYTTTWQDAIMQKAESGEDASLEESVNDLLLPIVKGYGSERSWVLLGTESLQTFGGSGFLQDYPIEQYVRDAKIDTLYEGTTAIQGQDLFFRKIVKDKGRAIGYLAEQVGEFVKSEAGNGRLKVERELLATGLDDAQAILGAAFTDLMASNPADEKGDLKNLYKVGLNTTRLVYVLGDLVVSWLLLRGAEVALAKLDEGATGSEKAFYEGKIAAASFFARTVLPRLTAERAMAENVDASIMELDEAAF
>NZ_CP011502.1|WP_067861149.1|139148_139721_-|HAD-family-hydrolase
MTLVDSRPGIGATYRALAEETGTFIDVDLVTSRLGPPLEAELAHWFEPEQVPEVADRYRALYPDLAIPRVALLPGAREAVQAVLDAGGEAFVVTGKNGRNAALHLEHLAIDLDVVGEVWREGKADVFRARGVTAYVGDHVHDMEACRSADVVGVAVPTGPCSPDELRAAGADHVVDDLHGVVGLVPHLSR
>NZ_CP011502.1|WP_067853276.1|140130_141045_+|LysR-family-transcriptional-regulator
MDVRRLMVLRELAERGSVGAVADAMRVTPSAVSQQLKTLEKEAGYPLVEPAGRGVALTEAGRALARAATDIAVAIERAEGEWRAFMEQPAGRVTLVTFPTGGEMLLPGLLTRMAERPDVELVCTDTEDPDAVGDLTADHDVVLSDSPTTSAAWHDRGLQVVPLMSEPLDVALPQDHPLARKANLSPRDVVDETWIGVPPGYPFDRVLEQVVVATGQPVQVAQRFADNGVVEAMVAGGHGLAILPRFTTREHGNGLVTRPLLGVRARREISAVLRPDRFERPSVRLVVQALREEARLVADAHGAA

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Crispr_ID: NZ_CP011502_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_4

141051-141155

Orphan

Consensus_repeat	Method
GATTCCCAGGTCGACCTGGGAATCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011502_4

>merge|NZ_CP011502|4|141051-141155|CRISPRCasFinder
GATTCCCAGGTCGACCTGGGAATCCCCCACCGCGCACGGGAATCTCAGCCAAGCACGGAGAGCAAGCCGTGCGCGGCTGGGATTCCCAGGTCGACCTGGGAATCC

>NZ_CP011502|4|4|141051-141155|CRISPRCasFinder
GATTCCCAGGTCGACCTGGGAATCC	CCCACCGCGCACGGGAATCTCAGCCAAGCACGGAGAGCAAGCCGTGCGCGGCTGG
GATTCCCAGGTCGACCTGGGAATCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067853265.1\|136146_136557_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP011502.1\|WP_067853256.1\|133896_134700_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|316740
NZ_CP011502.1\|WP_067853292.1\|145744_146986_+\|ammonium-transporter	unknown	unknown	gnl\|CDD\|223083
NZ_CP011502.1\|WP_067853262.1\|135505_136021_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853289.1\|143720_144668_+\|oxidoreductase	unknown	unknown	gnl\|CDD\|99782
NZ_CP011502.1\|WP_067853280.1\|141166_141919_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|180298
NZ_CP011502.1\|WP_067853309.1\|147824_148220_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197716
NZ_CP011502.1\|WP_067853253.1\|132917_133844_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235737
NZ_CP011502.1\|WP_067853284.1\|142804_143188_+\|ethanolamine-utilization-protein	unknown	unknown	gnl\|CDD\|380357
NZ_CP011502.1\|WP_083516157.1\|136546_136789_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176115
NZ_CP011502.1\|WP_083516539.1\|141941_142538_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|379207
NZ_CP011502.1\|WP_083516540.1\|144622_145657_+\|DUF3445-domain-containing-protein	unknown	unknown	gnl\|CDD\|378763
NZ_CP011502.1\|WP_067853312.1\|148392_149898_+\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NZ_CP011502.1\|WP_067853306.1\|146987_147326_+\|P-II-family-nitrogen-regulator	unknown	unknown	gnl\|CDD\|223424
NZ_CP011502.1\|WP_067853250.1\|131550_132846_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|349949
NZ_CP011502.1\|WP_067853287.1\|143184_143724_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853276.1\|140130_141045_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP011502.1\|WP_067853273.1\|137110_138988_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173842
NZ_CP011502.1\|WP_067853259.1\|134710_135505_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_CP011502.1\|WP_067861149.1\|139148_139721_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067853265.1\|136146_136557_+\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	2.88209e-06
NZ_CP011502.1\|WP_067853256.1\|133896_134700_+\|hypothetical-protein	gnl\|CDD\|316740	pfam14247, DUF4344, Putative metallopeptidase. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 247 and 291 amino acids in length. There is a conserved EED sequence motif. This is a putative metallopeptidase.	3.64724e-50
NZ_CP011502.1\|WP_067853292.1\|145744_146986_+\|ammonium-transporter	gnl\|CDD\|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	5.58276e-130
NZ_CP011502.1\|WP_067853289.1\|143720_144668_+\|oxidoreductase	gnl\|CDD\|99782	cd06185, PDR_like, Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur [2Fe-2S] cluster domain. Although structurally homologous to FNR, PDR binds FMN rather than FAD in it's FNR-like domain. Electron transfer between pyrimidines and iron-sulfur clusters (Rieske center [2Fe-2S]) or heme groups is mediated by flavins in respiration, photosynthesis, and oxygenase systems. Type I dioxygenase systems, including the hydroxylate phthalate system, have 2 components, a monomeric reductase consisting of a flavin and a 2Fe-2S center and a multimeric oxygenase. In contrast to other Rieske dioxygenases the ferredoxin like domain is C-, not N-terminal.	3.17893e-79
NZ_CP011502.1\|WP_067853280.1\|141166_141919_-\|enoyl-CoA-hydratase	gnl\|CDD\|180298	PRK05870, PRK05870, enoyl-CoA hydratase; Provisional.	1.27294e-84
NZ_CP011502.1\|WP_067853309.1\|147824_148220_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|197716	smart00422, HTH_MERR, helix_turn_helix, mercury resistance.	3.57149e-26
NZ_CP011502.1\|WP_067853253.1\|132917_133844_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235737	PRK06197, PRK06197, short chain dehydrogenase; Provisional.	8.46559e-108
NZ_CP011502.1\|WP_067853284.1\|142804_143188_+\|ethanolamine-utilization-protein	gnl\|CDD\|380357	cd02228, cupin_EutQ, Clostridium difficile EutQ and related proteins, cupin domain. This family includes bacterial and fungal proteins homologous to ethanolamine utilization protein EutQ found in Clostridium difficile, as well as in other bacteria, including the enteric pathogens Salmonella enterica and Enterococcus faecalis. EutQ is encoded by the eutQ gene which is part of the eut (ethanolamine utilization) operon found to be essential during anoxic growth of S. enterica on ethanolamine and tetrathionate. In C. difficile, inability to utilize ethanolamine results in greater virulence and a shorter time to morbidity in the animal model, suggesting that, in contrast to other intestinal pathogens, the metabolism of ethanolamine can delay the onset of disease. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization. In contrast to the metal-binding catalytic cupins, the EutQ family does not possess the histidine residues that are responsible for metal coordination in the oxidoreductase and epimerase classes of cupins.	1.33444e-29
NZ_CP011502.1\|WP_083516157.1\|136546_136789_-\|hypothetical-protein	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.80259e-05
NZ_CP011502.1\|WP_067853259.1\|134710_135505_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	7.33748e-13
NZ_CP011502.1\|WP_083516540.1\|144622_145657_+\|DUF3445-domain-containing-protein	gnl\|CDD\|378763	pfam11927, DUF3445, Protein of unknown function (DUF3445). This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 264 to 418 amino acids in length. This protein has a conserved RLP sequence motif. This protein has two completely conserved R residues that may be functionally important.	2.07411e-68
NZ_CP011502.1\|WP_067853312.1\|148392_149898_+\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	5.83538e-128
NZ_CP011502.1\|WP_067853306.1\|146987_147326_+\|P-II-family-nitrogen-regulator	gnl\|CDD\|223424	COG0347, GlnK, Nitrogen regulatory protein PII [Amino acid transport and metabolism].	2.85779e-48
NZ_CP011502.1\|WP_067853250.1\|131550_132846_+\|MFS-transporter	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	1.35055e-26
NZ_CP011502.1\|WP_067853276.1\|140130_141045_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.73822e-37
NZ_CP011502.1\|WP_067853273.1\|137110_138988_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	4.93846e-180
NZ_CP011502.1\|WP_083516539.1\|141941_142538_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|379207	pfam13472, Lipase_GDSL_2, GDSL-like Lipase/Acylhydrolase family. This family of presumed lipases and related enzymes are similar to pfam00657.	6.28389e-20
NZ_CP011502.1\|WP_067861149.1\|139148_139721_-\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	1.33461e-19

>NZ_CP011502.1|WP_067853276.1|140130_141045_+|LysR-family-transcriptional-regulator
MDVRRLMVLRELAERGSVGAVADAMRVTPSAVSQQLKTLEKEAGYPLVEPAGRGVALTEAGRALARAATDIAVAIERAEGEWRAFMEQPAGRVTLVTFPTGGEMLLPGLLTRMAERPDVELVCTDTEDPDAVGDLTADHDVVLSDSPTTSAAWHDRGLQVVPLMSEPLDVALPQDHPLARKANLSPRDVVDETWIGVPPGYPFDRVLEQVVVATGQPVQVAQRFADNGVVEAMVAGGHGLAILPRFTTREHGNGLVTRPLLGVRARREISAVLRPDRFERPSVRLVVQALREEARLVADAHGAA
>NZ_CP011502.1|WP_067861149.1|139148_139721_-|HAD-family-hydrolase
MTLVDSRPGIGATYRALAEETGTFIDVDLVTSRLGPPLEAELAHWFEPEQVPEVADRYRALYPDLAIPRVALLPGAREAVQAVLDAGGEAFVVTGKNGRNAALHLEHLAIDLDVVGEVWREGKADVFRARGVTAYVGDHVHDMEACRSADVVGVAVPTGPCSPDELRAAGADHVVDDLHGVVGLVPHLSR
>NZ_CP011502.1|WP_067853273.1|137110_138988_-|acyl-CoA-dehydrogenase
MSHYKSNLRDVEFNLFELFGRQDVLGTGAFEELDLDTAKSILAETERLAREDLAPSFEDSDRNPPVYDPKAMTVTMNPAFAKSYKAWMDAEWWRLQVPEELGGQKAPSSLIWAIGEFVLGANPPIWMYSAGPAFARIVFENGTERDKKIAEFMTNRQWGATMVLTEPDAGSDVGAGRTKAYPNEDGSWNIEGVKRFITSAEHDMSENIMHLVLARPQGVEGVGGPGTKGLSLFLVPKIHFDHETGELTGERNGAYVTNVEKKMGIKVSTTCEVTFGDPSTGGGEPAKGWLLGEVHDGINQMFRVIENARMMVGAKAIATLSSGYLNALEYAKERVQGADLTQAADKTAPRVTITHHPDVRRSLMTQKAFAEGLRSLVFYTTTWQDAIMQKAESGEDASLEESVNDLLLPIVKGYGSERSWVLLGTESLQTFGGSGFLQDYPIEQYVRDAKIDTLYEGTTAIQGQDLFFRKIVKDKGRAIGYLAEQVGEFVKSEAGNGRLKVERELLATGLDDAQAILGAAFTDLMASNPADEKGDLKNLYKVGLNTTRLVYVLGDLVVSWLLLRGAEVALAKLDEGATGSEKAFYEGKIAAASFFARTVLPRLTAERAMAENVDASIMELDEAAF
>NZ_CP011502.1|WP_083516157.1|136546_136789_-|hypothetical-protein
MSDSLDLVEDLVVAGLGVGMLPLWRRPRDGVTVVPFHDPGVTMRAHVWTRRGRATWPPLALVLERLLDAPSVSQPRVVTS
>NZ_CP011502.1|WP_067853265.1|136146_136557_+|DoxX-family-protein
MDGVFLISRILFAYLVIGSGIGHLTATGAMAGYAESRGLSNAKVLVQVSGVALLAGGVSVLLGIWGDVGALGLAILLLVTAVLMHAFWKESDAQAKQMEMVAFNKNVALAGGALALFVLLSTDFAPYTLTGALINW
>NZ_CP011502.1|WP_067853262.1|135505_136021_-|hypothetical-protein
MRLTSPLWYLAAFLLAIGGWMASAVVAAGAWDHVRDATLQNLTERVDAKGASLAVFTDVRQPERDVTCTATGPAKGAEPVTLEDAPIDLRVPQDGSTWYLIAFEREGSDQVAVRCTPKDRAADAATYRVAVADGFLDRTRNGAGIAWIAAAVAVALALATWWTRRKRTLED
>NZ_CP011502.1|WP_067853259.1|134710_135505_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MLQTYVDAWLASVRDTIALLEELDDAAWSTPTDLPGWTVADVAAHLAHLEAVTAGHVVDEAPTTASAGGIASVYTEAGVESRRGLTREQVLDELRRSVDVRAERLGGALPDDPTARAEHTPAGVGWTWDTMLRNRTVDVWCHEQDVRRAVDRPGNLDSAGAHVTTHTFAAAMPFVLGKKVGATAGTSVLWDLTGPIALQVGATVGDDGRARPGVPDSPTATLTLTSDAFAVLAAGRRRPGAVEVAVSGDTDLAHRVLEQMAVTF
>NZ_CP011502.1|WP_067853256.1|133896_134700_+|hypothetical-protein
MRRIIVVATVALAALGGFTVGLLAAPGDARPEAAQGDAARGARVSVTYPDVADRWQGWQDRVRASGVLEDAARDLRATVSLPSPLVVEVTTCKDGTGYLAGEGRIELCLQDVRDSDAELEEAGADDVDATLEGIWRETFFHEAGHAVIDMLDLPFTGREEDVADQFAAWRLAEAGDDEATGALLSSAYEYQLLAAAYEADPTDEHTSDAARAVNYLCYLYGSDPDTWSGLVDDDPLTQDRADQCTDEWDRLRVGWRDLLAEAGALRS
>NZ_CP011502.1|WP_067853253.1|132917_133844_-|SDR-family-NAD(P)-dependent-oxidoreductase
MSWSTQDIPDLGGKRAVVTGVTGGLGFHTALELGRAGAGLTVTARNPQKADDTLARLREELPDVDVEVLSLDLADLADVRRATEELGSRHDRVDVLVNNAGIMIPPYSTTADGFELQIGTNHVGHFAWTAQVWPLLADDARVVSVSSLAHLQAKGIDLRSLTPEGSPRTYRRWVSYAESKLANLSFALELDRRLKSAGKAVVSTAAHPGFARTELQKTGVAMGNPFLGTVVQQVSALASQSAAAGALPSLRAATDPTFTGGEYVGPASLGGTRGAPVIAGMTRWARDEQLARDLWAATEQATGVTFEV
>NZ_CP011502.1|WP_067853250.1|131550_132846_+|MFS-transporter
MSATTRRGPVAVWLTGLSLYFLAVFHRSSLAVAGLAATERFGISAAQLSTFVMLQLVVYAGMQIPVGLLLDRFGPRRILTIGVVVLTLAQAAFALADTFAVALVARVFVGLGDAMTFVCVLRLVTTWFPSRRIPLVTQLTGVLGQLGALVAAVPMTWALRELGWTPTYLAAASLGLVLLVVLLVVVHDEPGSPRVLGAPLSWTTVRSSLAASWRHPGTRLGFWVHFTTQFSATTLGLLWGYPFFVRGEGRTSAQAGALLTILVLAVMVAGPVLAWAITRDPWHRSTIVLGIVGSIVAVWTVVLAWPGTAPSWLLVLLVVVVGVGGPASMVGFDLGRSFNPPDRLGAATGIINQGGFVASLLLVVAIGLVLDWRTPGASTDYAPGAFRWAMSVQYVLWAVGLTQIWRYRRRTRAQLLAEDPDAREHWRGRLA
>NZ_CP011502.1|WP_067853280.1|141166_141919_-|enoyl-CoA-hydratase
MSFVLLQSDGPLRTITLNDPERLNALDWPLLDELRDAVATVAADEHARALLVTGAGRAFCSGANVTNLFGDRTRPVDELREHLMKVYASFLPIRDLAIPTIAAVHGPAVGAGLNIALACDVIVAGPRAGFGPTFTQIGLHPGGGCTWMLTQRIGSANTAAALYASDVITADDALRLGIAQEIADDAQTRARDVALGWCERNPTLMAHVKQSLRVAATSDAATSLDVEAQFQAESLSSPEFERFAARFAKD
>NZ_CP011502.1|WP_083516539.1|141941_142538_-|SGNH/GDSL-hydrolase-family-protein
MEQVEPYARWWEDANRRALGSGRPLWVALGDSMTQGIGASAPDRGWVGQLAGDPPSALRDVAVLNLSFNGARVLDVLDRQLPALEQVRALGHEVALVTLLIGNNDLMSPRWSRRLPAATEQLLDAVPRGTVVATQPGLQRSAVAFNRVVDARARRGEIRVADFRVPHMRDWRGRLAEDRFHPNDRGYAGMAEVVRRAL
>NZ_CP011502.1|WP_067853284.1|142804_143188_+|ethanolamine-utilization-protein
MTADTQTATSVPPFRVTADGHVGLPPMNVGSTLGFIGDVYENPDDSVMCSGYFELLHTDAPLEYVYDYDEMKVVLEGELHLVNLDTGQELVARRHDAIFFPRGSRIGFSTPDRALAFYTGHRDASLL
>NZ_CP011502.1|WP_067853287.1|143184_143724_+|hypothetical-protein
MNPALELTSVPAWAVRPSTPPCDPTATACTAVAVGPDAVDVATTWLDEAVAPGRLHAADDTDEALAVVDAELAEARVGWRLLVAGPLTAVLPLRAHGLAGGLVDAELAVATTSTEELPVACAHCAAVTWAPTHVGGVVACTGCERRLVVHHHVSRRQGTFLGFQVDAERWETGQWEEGA
>NZ_CP011502.1|WP_067853289.1|143720_144668_+|oxidoreductase
MSAALDLVVAAVDDTVPGVRSVRLVRPDGGALPGFTPGSHVVVTCGPPGAPGNAYSLTGDSVAPRAYTISVLRLDAGRGGSRWVHALTTGDRVEVTPPRSAFPPVLAARRHLLVAGGIGVTPILSHLRSAVRWGRDVEVLYAHRPGAAAHLDDLRDLAGDALTCLTDRTTLGDHLQRRLADQPVGTHLYTCGPAGFMDTVTLAARRLGWPDERIHVEHFGVDDLDPGEPFEAVLRASGRTVPVPSGTSLLDALEGAGLSVPNLCRQGVCGECRVPVAAGTPLHRDLVLTDAEKAAADTLLCCVSRAADDRLELDL
>NZ_CP011502.1|WP_083516540.1|144622_145657_+|DUF3445-domain-containing-protein
MRVAGRRRPTGARPVTTQPSVDRALVAGFPFPFPTDRYRYSTNVEPAPRVVSTPAGQWGASLVDVDGEYHRELDERAAVLERDPSRYAVLDHMAPACWDTMLTLMRELAAAYPDVMSLDGDGPSYVWTNRLFDVEQPFTYAQPSTLPDEPLRYVASQVQEDLVLLDQRDGDLWGDAGLVTFAADWSFGFDVGMSFLEIHGPVPRLRETGVITRAREFIMRLQPGAPYRRTNWTLTVGRRLDVSTERYPEWGPDRPRMLTVDDVTFGREVHLRTEVQHLVRLEESGAVLFLIRTYLLPFEELARVEPWRATTAAVLADLPDDIADYKGIAGYRDRAVDWLHAHAP
>NZ_CP011502.1|WP_067853292.1|145744_146986_+|ammonium-transporter
MTAADVAWMLAAFAVVLIMFPGIALFYGGMVGPRNALNMLMMCMSTLAVVSVLYVLYGHGVVVGDSLGGWRVIGDPLQHLGWTGIYDDPGDGSIIDPYWFSFYVLFAAITVAIVASAAVGRMKFSAWLVFSGVWLTLVYLPLGHQVFAFDGEDTKGGWLRNVVQLHDYAGGTAVHMSAGFGALALALVLGKRRTVQMRPHNLPIVLVGVGMLWMGWIGFNGGTAGGANFLAQFAIMSTLLAGCTGMIGFCLVERVRDGHATTLGMCSGVIAGLVGITPSADAVDALGALFVGFASGAVVAWAVTWKSRLGIDESLDAFAVHGIGGIVGSLCVVLIGFEGAPAGIRGILLGGSWDIVWREVVGIVVVSGYAFVATYVIARVLDRVMGLRAPEEHELEGMDLTQHAESAYDLERT
>NZ_CP011502.1|WP_067853306.1|146987_147326_+|P-II-family-nitrogen-regulator
MKLVTAVVQPHRLDDVKEALTGLGMAGLTVTEVSGHGAQKGHAEVYRGAEYRVDFRPKVRVDVVVSDADLEAVLDAVTEAARTGRIGDGKIWATDLVEVVRVRTGERGESAV
>NZ_CP011502.1|WP_067853309.1|147824_148220_-|MerR-family-transcriptional-regulator
MTDGSGDASAFMQIGEVAARTELSLRSLRHWEEVGLLHPSGRTEGGFRLYTEDDVEKILVIRRMKPLGFSIEEMKAVMADLEALRGTGSPDDARAHLAQVRADAVARREKLERQLAMADEFLALLERESDG
>NZ_CP011502.1|WP_067853312.1|148392_149898_+|SulP-family-inorganic-anion-transporter
MSSTAVPVHEPTTVRAALRSPRVLRTEVLAGLVVALALIPEAISFSIIAGVDPRVGLFASFTMAVAISFLGGRPAMISAATGAIALVIAPVMREHGYDYLIATVLLGGAIQVVLALVGVARLMRFVPRSVMVGFVNALAILIFQAQLTHLVDVPWLVYPMVAVGIAVIVGFPRVNAVVPAPLVAIIALTGFTLLASITVPDVGDQGTLPDSLPSWFLPDVPLTLDTLRIIAPYALAMAVVGLLESLLTAKLVDDITDTPSDKTREAVGQGAANVITGFFGGMGGCAMIGQTMINVKVSGARTRISTFLAGVFLLVLVVGFGDVVALIPMAALVAVMMMVSVGTFDWHSVRPATLRRMPRSETAVMLVTVLGTVLTHNLAIGVVVGVLAAMTLFARRVAHLTDVERTVSSDADGTTTATYRVTGQLFFASSNELYTRFDYADDPARVVVDLSDARVWDASTVAALDAITTKYARRGSNVDIVGLDPASAERHERLTGRLGGH

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Crispr_ID: NZ_CP011502_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_5

251966-252051

Orphan

Consensus_repeat	Method
GAGCGCGTTTGCGTGGGGCCCCACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011502_5

>merge|NZ_CP011502|5|251966-252051|CRISPRCasFinder
GAGCGCGTTTGCGTGGGGCCCCACGTGAACGTGCACATCGGCCGCATGTTTGCGGTGGGGCGAGCCCGTTTGCGTGGGGCCCCACG

>NZ_CP011502|5|5|251966-252051|CRISPRCasFinder
GAGCGCGTTTGCGTGGGGCCCCACG	TGAACGTGCACATCGGCCGCATGTTTGCGGTGGGGC
GAGCCCGTTTGCGTGGGGCCCCACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_158509157.1\|258762_258930_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853606.1\|260863_264106_-\|cobalamin-B12-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|239650
NZ_CP011502.1\|WP_067853593.1\|258010_258766_-\|cobalamin-binding-protein	unknown	unknown	gnl\|CDD\|238564
NZ_CP011502.1\|WP_067853555.1\|245260_245557_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|316153
NZ_CP011502.1\|WP_067853587.1\|256615_257995_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP011502.1\|WP_067853600.1\|259502_259913_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NZ_CP011502.1\|WP_144433626.1\|246837_247572_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853561.1\|246343_246817_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853552.1\|243754_245128_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|215457
NZ_CP011502.1\|WP_083516168.1\|250329_251934_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|99778
NZ_CP011502.1\|WP_067853567.1\|247597_247903_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853584.1\|255514_256552_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853579.1\|252175_254791_+\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529
NZ_CP011502.1\|WP_067853581.1\|254882_255413_-\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_CP011502.1\|WP_067853609.1\|264217_264718_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP011502.1\|WP_067853597.1\|258992_259493_-\|thioesterase-family-protein	unknown	unknown	gnl\|CDD\|372545
NZ_CP011502.1\|WP_067853558.1\|245553_246177_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853570.1\|247899_248202_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067853573.1\|248198_249434_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067861168.1\|249460_250333_+\|FAD:protein-FMN-transferase	unknown	unknown	gnl\|CDD\|376782

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067853606.1\|260863_264106_-\|cobalamin-B12-binding-domain-containing-protein	gnl\|CDD\|239650	cd03678, MM_CoA_mutase_1, Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The reaction proceeds via radical intermediates beginning with a substrate-induced homolytic cleavage of the Co-C bond of coenzyme B12 to produce cob(II)alamin and the deoxyadenosyl radical. MCM plays an important role in the conversion of propionyl-CoA to succinyl-CoA during the degradation of propionate for the Krebs cycle. In some bacteria, MCM is involved in the reverse metabolic reaction, the rearrangement of succinyl-CoA to methylmalonyl-CoA. Members of this subfamily also contain an N-terminal coenzyme B12 binding domain followed by a domain similar to the E. coli ArgK membrane ATPase.	0
NZ_CP011502.1\|WP_067853593.1\|258010_258766_-\|cobalamin-binding-protein	gnl\|CDD\|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	5.77561e-44
NZ_CP011502.1\|WP_067853555.1\|245260_245557_-\|transcriptional-regulator	gnl\|CDD\|316153	pfam13601, HTH_34, Winged helix DNA-binding domain.	1.60821e-21
NZ_CP011502.1\|WP_067853587.1\|256615_257995_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	1.24613e-125
NZ_CP011502.1\|WP_067853552.1\|243754_245128_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|215457	PLN02852, PLN02852, ferredoxin-NADP+ reductase.	3.81626e-136
NZ_CP011502.1\|WP_083516168.1\|250329_251934_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|99778	cd00322, FNR_like, Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in many organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one- electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and 2 electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.01854e-41
NZ_CP011502.1\|WP_067853579.1\|252175_254791_+\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NZ_CP011502.1\|WP_067853581.1\|254882_255413_-\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	2.11078e-14
NZ_CP011502.1\|WP_067853609.1\|264217_264718_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.46409e-23
NZ_CP011502.1\|WP_067853600.1\|259502_259913_-\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	0.000568708
NZ_CP011502.1\|WP_067861168.1\|249460_250333_+\|FAD:protein-FMN-transferase	gnl\|CDD\|376782	pfam02424, ApbE, ApbE family. This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis. It acts as an FAD:protein FMN-transferase, catalyzing the attachment of an FMN residue to a threonine residue of a protein via a phosphoester bond in such bacterial flavoproteins.	3.88821e-27
NZ_CP011502.1\|WP_067853597.1\|258992_259493_-\|thioesterase-family-protein	gnl\|CDD\|372545	pfam13279, 4HBT_2, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	4.40339e-18

>NZ_CP011502.1|WP_083516168.1|250329_251934_+|FAD-dependent-oxidoreductase
MSTSRTSTGPRPSVDAILGRVSMYRLTTIVLSAIVAVYLLFTSTGVIDGLSTLGNLAALAVLLVASVASNRLLGLVWRRVPHDESAVITALLLFFLFVPLPEAASGSGSGVGAANLLWLAAAAVLASASKYLLAWRGRHVLNPAAAGALLVVVAQWAVGRESSINALWQTAATQALLPFVAVGALLVLWRTRRLDVGLVFVVVAATLVLVGLTVGFGTPLSQAWQTALYSYPIVFMAGFMVTEPLTLPPRRVQQWLVAAVMAVLLGFPTFADVLGVQAPTWGPLTMTPELAIVVGNLVAFALSRRTGVVLRTTGSRRLAGDTWEVTFRPTRPVRFVPGQYLELHLPHRGVDGRGVRRVFSISSPPQADDLSVAVRVPEPSSSFKQALVGLREGERVHATGVHGDFVWPRGGRPLLLVAGGIGVTPFLSQLRAGEARDVVLVYGVPDGDVVPYRDELVATGVRVVLVSPEPPADLPADWVHVAAPVVSGDVVAEAVPDAAERVAYVSGPPVMVSAVRGDLRRRCAKVRTDYFSGY
>NZ_CP011502.1|WP_067861168.1|249460_250333_+|FAD:protein-FMN-transferase
MAWGFEAIGTSWEVETAQPLDPDVRQAVRDVVERFDHAWSRFRADSTVTAMAREAGSWQLQGAGALLRLYDDLHVATDGAVTPLVGRSLEDLGYDARYSLQPNGRAVPPESWAQVRSDGSLVVDHETLATARPLLLDVGAAGKGFLVDLVVDVLADHGVDEATVDGSGDLRHVGGVPIRVALEHPGDASRAVGVVEVADGWALCASAVNRRVWGEGLHHVVDGRTGRPTRDVVATWALVDGSCMVADGLATAHFFADPQTLLDLHPHHFVRIHADGRVLRSPDLPGELFT
>NZ_CP011502.1|WP_067853573.1|248198_249434_+|hypothetical-protein
MSIDTEIEGSPSSVKGVATWLRQTLATALDDAAEAASTARTSALGSWDGEAGDEFLDVARRLRTGGDDLAGAARDMAGDLDEFATSLTTCQSDMADVRSTAREAGLTVAGFVVPHPGDGPARPPEHFEGTEAEVAARDQRVAEYNAHQDKLTAYAAAQTEASRVDRVYETACRSLQDQYTPGQHASWLLSLAEAVGEGAAAGVASQRANALRTQAQGLLDEASRAIADLQANPDRYVQRRWFFFERVDTARLEADRLAIAGKLDEAQDLLARANAAGESRLPANLGRVGKALGVIGLGLGVYNDYAEGETAPQIATSQGVSFLAGMGTGAAAGAAIGSVVPVAGTAVGAVAGTIIGAGVAIFSDGMIDSFFENGPDVGEALSEGVEALGDTASAIGDGIGGAVSAVGGWFD
>NZ_CP011502.1|WP_067853570.1|247899_248202_+|hypothetical-protein
MSIDVDLAVLGTIATDLTDAGTTLSGIDTAGSSGVDAGPMTAVIASMVAQVIDSAANVADGLSGTGALVGLSRDYYQRADADAEVSLEDIRSTMQEEGGR
>NZ_CP011502.1|WP_067853567.1|247597_247903_+|hypothetical-protein
MTQPFVQAGTGRPALPPVVYVPTSAADDPSLREVQMHTLEDGRTALFVYSAIDRLHDLYRPDVPWLLCDVATLQRVHDETPYDLLFLDLDPGLRDGEQARR
>NZ_CP011502.1|WP_144433626.1|246837_247572_+|hypothetical-protein
MGDAETTSYDRRARRADLGADLATLVFGLAGAAVILTQVPADVVAMQALAVYALFAALGAGVLAVARLRTRTFPGLREATVDGRPARGVRAWSGPFVHSVSLDVGLVALGAVVSSIGVASGSAWAALWVPALVATAWFAVRVVLVLVGRRRVDALWLTDQHVVHDSAAGRARIPRTDVESVRPWSGGLFVDGPTGRSGPPLGFRAGARARPGELRVDTSLMGVGPHDLAAWLREQLDDDARPRR
>NZ_CP011502.1|WP_067853561.1|246343_246817_+|hypothetical-protein
MTLRRHQKAVLAATAVPTLLLAAACGQASTSDDAAGSTPSSAATSESASTDTGSSESSGDYAPGTYEASGSYSNPGGTSTVDVEVTLGDGGTIDDVTVTPKASGTSKQYQEKFAGGIADEVVGKNIDDLDVSKVAGSSLTAGGFNQAIDEIKSEARG
>NZ_CP011502.1|WP_067853558.1|245553_246177_-|hypothetical-protein
MDDEQTRDRTPDLAESWAIIEAERDRARRSVRVDERIVYGVWAVAWGMGYLALWTWSGPQGEPGLPGPIVFGVLIAAAIVATVVHIEGRTRGIGGPDAEANAWLGWAWGLGFAGACLVAGALGRVGLEGEAAAIVYNAVPCLVVAVLYMGSAVAFHDRRQLVLGAWIALLVGGASFAGAPALYLLMALLGGGGFAVAALHAHREGRR
>NZ_CP011502.1|WP_067853555.1|245260_245557_-|transcriptional-regulator
MTDLDPVIHAQARLRVTAFLAALAPGETLTFPRLQKELGMTAGNLSTHLRKLEDAGYVHQTKTIDGRTPATHVSLTDAGRTAFETYTRTLRQLLQGDA
>NZ_CP011502.1|WP_067853552.1|243754_245128_-|FAD-dependent-oxidoreductase
MSRKLRVAIVGAGPAGVYAADILTKSEVPAPFEGASVDLIERDPTPFGLIRYGVAPDHPRIKEIVKALKRVMANKDIRFFGNVSFGDDLKLDDLRQFYDAVVFATGARRDRDLDLPGIDLDGSHGAADFVYWYDGHPDVERDWPFQPHQESVAVLGVGNVGLDVSRILAKTADELLVTEIPDNVYEGLKKNVAKDVHVFARRGPAQVKFTPMELRELSHSPTIDVIVHPEGFELDEGSLEAIRAAKSQKLVVDVLQNYLAKEPTGAPHRIHIHFCQNPVEILGEDGKVVGLRTEVTELDGTGNVRGTGEFQDWPVQAVYRAIGYYSDNLPGLPFDVTAGVVPNDGGRVIEIDGSALPGVYVTGWIKRGPVGLIGHTKSDAAQTISMLIDDAPGLAPAAQPDPESVDAYLESRGLEYTTWEGWEKLDAHELGLGEAHEHERERVKVVPREDMVRIARS
>NZ_CP011502.1|WP_067853579.1|252175_254791_+|ATP-dependent-chaperone-ClpB
MDLSNLTTRSQQALAAAMQQAAAAGNPAIEPAHVLTALLAQDGGTAVPLLQATGVDAGAVRTELQGVIGALPSAAGSSVQNPGLSRSTHEVLQRAADLAGELGDEFISTEHLVVGVATVDSPAKDVLTSRGATPDALRAAFETVRGGARVTSADAEDTYQALEKYGVDLTAVAREGKLDPVIGRDAEIRRVVQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQRIVDGDVPESLRGRRLISLDLGAMVAGAKYRGEFEERLKAVLEEIKASDGQVITFIDELHTVVGAGATGDSAMDAGNMLKPMLARGELRMIGATTLDEYRENVEKDPALERRFQQVLVGEPSVEDTIAILRGLKERYEAHHKVAIADAALVAAATLSDRYIPGRQLPDKAIDLVDEAGSRLRMEIDSSPVEIDELRRAVDRLRMEELHLQNETDDASRERLEKLRSELADRQETLRALEQRWESEKQSLNAVGEIKERIDEVRIAAERAQREGDLETAARLLYSEIPTMEAQLAAAQAAESAREAGDGTDRLVNEEVTADEIAEVVASWTGIPTGRLLEGETGKLLRMEDELGKRLVGQREAVTAVSDAVRRSRAGIADPDRPTGSFLFLGPTGVGKTELAKTLAEFLFDDERAMVRIDMSEYAEKHAVSRLVGAPPGYVGYDEGGQLTEAVRRRPYSVVLLDEVEKAHPEVFDILLQVLDDGRLTDGQGRTVDFRNVILILTSNLGSVFLADPSLDEQAKKDAVMDVVKASFKPEFLNRLDEIVTFEPLGTAELTHIVDLQLASLGRRLAARRITLDVTDAAKEWLALTGWDPAYGARPLRRLVQQAIGDRLAKALLAGEVRDGDTVRVDREVGPDGVPTDSLTVTAA
>NZ_CP011502.1|WP_067853581.1|254882_255413_-|VanZ-family-protein
MFRQVPVLPVVVLSAAAVLAVLLWHLRRRALLTAPRAAVALALCVYAAGVVANTVFPIYLDPVARSTRWSVQPVPFADYEWADAAMNVAVFVPLGILLALALGTPPWWRVLVAVAASSLAIELTQLVTGAFLGGGHVADVDDLLSNVTGGMLGLALLVGLNRVPAGARLVERSRWS
>NZ_CP011502.1|WP_067853584.1|255514_256552_+|hypothetical-protein
MADRPPRPPALTLTCIFVGVGCGLLLVNLVSALSSWGSIELQDAVRDALAQEPVKELGLSMDQALDYLRYAVYVGIVLTASGAVFAVYAARGHRTSRVMLTILCGIAFVVLATLGLPGLLPAAFAGLCGWSLWTPDARRWFDQVGGRAVADVPTSATKGADPFASRSAGPVGRPLDPPPAAGGPVATTTPTHPSAQPAPVGPVARPRSVTVAVVTTFVASGVVALLGLLLLLVTTVGADAYRTALTEPGLARDLVRSSGVSADEMIELLRVSAIVWLVACVAGVVAALAVVRRVPSGGTALVVVAAVTIGLSVFFLPLGVVTGAAAIVVIVQLRRPESRAWLSEE
>NZ_CP011502.1|WP_067853587.1|256615_257995_+|NAD(P)/FAD-dependent-oxidoreductase
MSNSVVPGSKRPHVVVVGGGFGGLSLVRKLKRADVDITLIDRHTYNTFQPLLYQVATASLNPGDITWFLRAVRAGQKNVRFLKGIVTSIDHQAKVLSLHGEVSVSYDYLVLANGVTTNFFGTPGAEEYSLPLYKRSQALQVRDRLFANLEEFAINGQDEDLRIIVVGGGATGVETAGAFAEFRNNDMPTTYPELDRARIHVTLLEMAPHVLGPFDEKLRDYAKRSLLKRDVDLRLNTAVKEVREDGVLVEAEGRTEFLKAGIVVWATGVTAHPTVLDWDVPQGRGGRIEVDDHLRVKDRPDVFAIGDIAIGPDPLPQLAQPAIQGGKHVAKFIKATTKGKADRVKPFKYSDKGTMATIGKSSAVAEITHAPKLTGFLAWIIWVALHIATLLGNRNRFATLINLSSKYLFSGSHNAIVGETPYVVSKHKLEITPLEKQKAERRVLERKAAAHEQEREHQS
>NZ_CP011502.1|WP_067853593.1|258010_258766_-|cobalamin-binding-protein
MTLDDLGHDVAVPTEARRVVSLVPSITEGLAAARPAAVVGATDWCTHPPDLDVVRVRGTKNPDRAAVEAARPDLVVANQEENRELDVQRLRDAGVPVWVTRIETVDDAFASLGRLFTDALGWGEPTWLADARQLWSAPAPAPRGRVAVPIWRDPWMVVGPRTFTADLLRRLGWEVTTGPEGDAHERYPHVDVADLDTSGVDLVLLPDEPYVFGPDDGPEAFTSVPTRLVSGRLLTWYGPSLVEAREVLGAL
>NZ_CP011502.1|WP_158509157.1|258762_258930_-|hypothetical-protein
MLAWGFIMVAVVVVLVVAGLGIAAASGRDGAERRSAMAEARQRAQARREARSDGA
>NZ_CP011502.1|WP_067853597.1|258992_259493_-|thioesterase-family-protein
MTTIPAYEQVASLPTVHEHVVGPEHLDENRHMNIAHYFTFGGSAIWARHQRDLAMADTYITERGLTTFTAEQHLRYLGESVEGDRLGVSVVVVDRADKVLHVAALITNHTRRELSCVMEAVTVHVDFGTRRPVPFPDDVAAVLDAAIAGDRPAWELPLSGGLGVRR
>NZ_CP011502.1|WP_067853600.1|259502_259913_-|hypothetical-protein
MDTWVWIVIAVVVALVVLAAVIVAARRSGEARRIRDRDRAVTLREEAAEAQVAAGRTEAGAAVARADADEARLEADRLERHAVDLENEAAEAQGRADDRLAEADRLDPDVADSGRPAGGPVEGEGEHSADPTEPRR
>NZ_CP011502.1|WP_067853606.1|260863_264106_-|cobalamin-B12-binding-domain-containing-protein
MTALHVPTHPVRLVTASALFDGHDASINIMRRIFQSQGAEVIHLGHNRSVQEVVDAAIEEDVQGVAVSSYQGGHVEYFEYLVESLREQGAGHVQVVGGGGGVIVPEEIARLRASGVTIFSPEDGQRMGLAGMISSVVEACDIDLTSLGALDVDAVLAGERAAVARAITFAETGRLTGADLERVRAAAAGHSSPVLGITGTGGSGKSSLTDELVRRFRVDQQDKLRVAVVAVDPTRRRGGGALLGDRIRMNSLGGAMSGGERTYFRSLATRGSHELPDCLDDVVAVLKAAGFDLVVVETPGIGQGDAAIVPHVDTAIYVMTPEFGAASQLEKIDMLDFADVVAINKFERRGAKDAYRDVGRQLVRNREAFGKKPEDMPIFGTSAATFNDDGVTALYQHLRDHLAERGLPVAEGTLAPVAVRCSSGIQAVVPADRARYLSEITETVRGYHAETERLADAADRAQRLQTTAAELDDAGLDADAVTTLLESARRQVPHDVADQIAGWPAVVESYSGDEQVVRVRDREIVTQLTRESLSGNKIPRVSLPRFTGHGDLVRFWRRENLPGFFPYTAGVFPFKRDGEDPARMFAGEGDPFRTNRRFKLLSEDGEATRLSTAFDSVTLYGRDPDPRPDVYGKVGTSGVSVATLDDMKALYDGFDLVSPSTSVSMTINGPAPTVLAFFLNTVIDQQVDAFREREGREPDETEHAELRSYALKNVRGTVQADILKEDQGQNTCLFSTEFSLRMMGDIQQYFIDEGVRNFYSVSISGYHIAEAGANPISQLAFTLANGFTYVESYLARGMDVDDFAPNLSFFFSNGMDPEYSVLGRVARRIWAVAMKEKYGANERSQKLKYHVQTSGRSLHAQEMDFNDIRTTLQALIAIYDNANSLHTNAYDEAVTTPTTESVRRALAIQLIINREWGLAMNENPLQGSYVIDELTDLVEAAVLAEFDAINERGGVLGAMETGYQRGRIQDESMLYEHRKHDGSLPIIGVNTFRRPDAEGEEHVVELARATESEKQSQLDRVHAFQQAHRSSAEEAITRLKDAATSGENVFAVLMEAARVCSLQQVTEAFFEVGGQYRRNV
>NZ_CP011502.1|WP_067853609.1|264217_264718_+|MarR-family-transcriptional-regulator
MPQEPRLAFDPLERAGELWEERIGDATAMRLATSIMRVHQLVISRLDAALKPHGITFARFEVLRLISFSRAGRLPLSKIGERLMVHPTSVTNAIDRLEAQGLVVREPDPTDRRRTFASLTPDGERVVEDATAALMDVQFGVAQLDADDQQAAYALLRGLRQVDFGA

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Crispr_ID: NZ_CP011502_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_6

421416-421500

Orphan

Consensus_repeat	Method
GTTTGCGTGGGGCCCCACGCAAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011502_6

>merge|NZ_CP011502|6|421416-421500|CRISPRCasFinder
GTTTGCGTGGGGCCCCACGCAAACCGGCTCGCCCCCACGCAACCGTGCGCCGGATCTGGGCGTTTGCGTGGGGCCCCACGCAAAC

>NZ_CP011502|6|6|421416-421500|CRISPRCasFinder
GTTTGCGTGGGGCCCCACGCAAAC	CGGCTCGCCCCCACGCAACCGTGCGCCGGATCTGGGC
GTTTGCGTGGGGCCCCACGCAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067853982.1\|425977_426955_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380478
NZ_CP011502.1\|WP_067853944.1\|410630_411320_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224332
NZ_CP011502.1\|WP_067853988.1\|428602_429607_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119321
NZ_CP011502.1\|WP_067861203.1\|412386_413631_-\|ammonium-transporter	unknown	unknown	gnl\|CDD\|223083
NZ_CP011502.1\|WP_067853969.1\|422914_424420_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341259
NZ_CP011502.1\|WP_067853996.1\|430464_431700_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173844
NZ_CP011502.1\|WP_067853965.1\|421576_422779_-\|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl\|CDD\|180843
NZ_CP011502.1\|WP_067861208.1\|418287_419469_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NZ_CP011502.1\|WP_067853974.1\|424416_425226_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP011502.1\|WP_067853957.1\|419465_420731_+\|allantoate-amidohydrolase	unknown	unknown	gnl\|CDD\|236456
NZ_CP011502.1\|WP_067853954.1\|416959_418291_+\|FMN-binding-glutamate-synthase-family-protein	unknown	unknown	gnl\|CDD\|239202
NZ_CP011502.1\|WP_067853949.1\|413953_415276_+\|type-III-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|274431
NZ_CP011502.1\|WP_067853947.1\|411323_411794_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371045
NZ_CP011502.1\|WP_067853961.1\|420741_421392_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380339
NZ_CP011502.1\|WP_067853985.1\|426959_428606_+\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NZ_CP011502.1\|WP_067853977.1\|425222_425885_+\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|319790
NZ_CP011502.1\|WP_067853951.1\|415314_416211_+\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|238888
NZ_CP011502.1\|WP_067853999.1\|431696_432476_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235975
NZ_CP011502.1\|WP_067853993.1\|429655_430465_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|180472
NZ_CP011502.1\|WP_067861205.1\|416252_416942_+\|protein-glxC	unknown	unknown	gnl\|CDD\|223148

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067853982.1\|425977_426955_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380478	cd01536, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of active transport systems that are members of the type 1 periplasmic binding protein (PBP1) superfamily. Periplasmic sugar-binding domain of active transport systems that are members of the type 1 periplasmic binding protein (PBP1) superfamily. The members of this family function as the primary receptors for chemotaxis and transport of many sugar based solutes in bacteria and archaea. The sugar binding domain is also homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR. Moreover, this periplasmic binding domain, also known as Venus flytrap domain, undergoes transition from an open to a closed conformational state upon the binding of ligands such as lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. This family also includes the periplasmic binding domain of autoinducer-2 (AI-2) receptors such as LsrB and LuxP which are highly homologous to periplasmic pentose/hexose sugar-binding proteins.	3.09627e-39
NZ_CP011502.1\|WP_067853944.1\|410630_411320_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	3.45785e-16
NZ_CP011502.1\|WP_067853988.1\|428602_429607_+\|ABC-transporter-permease	gnl\|CDD\|119321	cd06579, TM_PBP1_transp_AraH_like, Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group also contains E. coli RbsC, AlsC, and MglC, which are TMs of other monosaccharide transporters, the ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also be involved in low affinity ribose transport. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Proteins in this subgroup have a single TM which homodimerizes to generate the transmembrane pore.	1.75077e-70
NZ_CP011502.1\|WP_067861203.1\|412386_413631_-\|ammonium-transporter	gnl\|CDD\|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	1.47621e-135
NZ_CP011502.1\|WP_067853969.1\|422914_424420_+\|AMP-binding-protein	gnl\|CDD\|341259	cd05936, FC-FACS_FadD_like, Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD. This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	2.47728e-177
NZ_CP011502.1\|WP_067853996.1\|430464_431700_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	0
NZ_CP011502.1\|WP_067853965.1\|421576_422779_-\|acetyl-CoA-C-acyltransferase	gnl\|CDD\|180843	PRK07108, PRK07108, acetyl-CoA C-acyltransferase.	0
NZ_CP011502.1\|WP_067861208.1\|418287_419469_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	8.92997e-52
NZ_CP011502.1\|WP_067853974.1\|424416_425226_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.7069e-48
NZ_CP011502.1\|WP_067853957.1\|419465_420731_+\|allantoate-amidohydrolase	gnl\|CDD\|236456	PRK09290, PRK09290, allantoate amidohydrolase; Reviewed.	3.42738e-161
NZ_CP011502.1\|WP_067853954.1\|416959_418291_+\|FMN-binding-glutamate-synthase-family-protein	gnl\|CDD\|239202	cd02808, GltS_FMN, Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.	2.00242e-157
NZ_CP011502.1\|WP_067853949.1\|413953_415276_+\|type-III-glutamate--ammonia-ligase	gnl\|CDD\|274431	TIGR03105, gln_synth_III, glutamine synthetase, type III. This family consists of the type III isozyme of glutamine synthetase, originally described in Rhizobium meliloti, where types I and II also occur.	0
NZ_CP011502.1\|WP_067853947.1\|411323_411794_-\|hypothetical-protein	gnl\|CDD\|371045	pfam10428, SOG2, RAM signalling pathway protein. SOG2 proteins in Saccharomyces cerevisiae are involved in cell separation and cytokinesis.	0.000419012
NZ_CP011502.1\|WP_067853961.1\|420741_421392_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	2.39804e-17
NZ_CP011502.1\|WP_067853985.1\|426959_428606_+\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NZ_CP011502.1\|WP_067853977.1\|425222_425885_+\|HAD-family-phosphatase	gnl\|CDD\|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	7.03864e-35
NZ_CP011502.1\|WP_067853951.1\|415314_416211_+\|glutamine-amidotransferase	gnl\|CDD\|238888	cd01907, GlxB, Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases including glucosamine-fructose 6-phosphate synthase (GLMS or GFAT), glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase), asparagine synthetase B (AsnB), beta lactam synthetase (beta-LS) and glutamate synthase (GltS). The GlxB fold is also somewhat similar to the Ntn (N-terminal nucleophile) hydrolase fold of the proteasomal alpha and beta subunits.	2.89752e-66
NZ_CP011502.1\|WP_067853999.1\|431696_432476_+\|SDR-family-oxidoreductase	gnl\|CDD\|235975	PRK07231, FabG-like, SDR family oxidoreductase.	2.48264e-111
NZ_CP011502.1\|WP_067853993.1\|429655_430465_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|180472	PRK06210, PRK06210, enoyl-CoA hydratase; Provisional.	5.57168e-100
NZ_CP011502.1\|WP_067861205.1\|416252_416942_+\|protein-glxC	gnl\|CDD\|223148	COG0070, GltB, Glutamate synthase domain 3 [Amino acid transport and metabolism].	1.40776e-34

>NZ_CP011502.1|WP_067853961.1|420741_421392_+|helix-turn-helix-transcriptional-regulator
MTDDAPLLRNAAGSARDRDPAEPVEAMALEQAIAVNVRHHRTAAGLSVADMAQRLGLSKAMLSKIENAQTSCSLATLQRLATGLDVPVTSLVRGADEERQAVFTPAGQGPRIARHGTKEGHEYELLGALRGQHKRLESLMVTLTEDSQTYPLFQHPGTEFLHVLEGRMVYGHGRETYELGPGDSLQLDGEGAHGPVELKELPIRFLSVIAFPDASV
>NZ_CP011502.1|WP_067853957.1|419465_420731_+|allantoate-amidohydrolase
MTGAAPSPTRSRRPASVASLLADVRDVGRDPRRGGYSRFAYAPAELELRTWFEAEAARRSLDVVTDRNGILWAWRPGPGGSLDDAVVTGSHLDSVPGGGEFDGPLGVASAFAALDLLDARDVGGERPLAIVAFPEEEGGRFGRACLGSQLMTGEQDPDRVLGLLDADGTSLADALTGAGLDPVHLGRDEEALRRIGVFVELHVEQGRGLVDLDQPVAVASSILGHGRWRLTVTGEGNHAGATLMADRRDPMVAAAQVVVAVRDLASSRPDARATVGRLQPVPGGTNVIASRVDLWLDVRHPDDDVTRALVAQVLESAHAVCAAEGCAVELVEESYSGQVRFDAGLRDRLRGVLPDAPVLATGAGHDAGVLAAHVPSAMLFTRNPTGVSHSPEEHVDDADAEAGAAALADVLQDLLVPREPR
>NZ_CP011502.1|WP_067861208.1|418287_419469_+|FAD-binding-oxidoreductase
MSASRAVVVGGGLIGLSIARALTERGLGDVLVLERGLLASGGTGKSSGIVRAHYGVPSIAAMAWRSLPVFEALGAEVGFRQVGYTVVVGEENAGPLKDNTAMHQGLGIEVDLVDPDQVAALWPMMNVDDVALGAYEPRGGFADATQLALHYGQRARAHGARVRQNAPVARVVTSGSRVTGVELADGEVVEADLVVVAAGWWSARLLADLGVDFPVEAYRSELLVVDTGAPLPDLPVVSDLVSLQYCRLEGSGQFLVGNSDHADFGRKLVDPDHYSNHASDASLEAYAEKLLHRFPGFTDPSVTHTYAGVYDVPPDWNPVIGPVGDVDGLVLAAGFAGHGFKISPAVGDLVADLVLEGDSTDPDVPASDFRLSRFAEGDLLTSLHPYVGAGEMR
>NZ_CP011502.1|WP_067853954.1|416959_418291_+|FMN-binding-glutamate-synthase-family-protein
MTQYRTQPRTSATFDPATIAEIQRAADTGIYDIRGWGAKRALPHFDDLLFLGASMSRYPLEGYRERCGTDVVLGDRHAKYPLHLETPVTIAGMSFGALSGRAKEALGRGASEVGTSTTTGDGGMTPEERSQSKHLVYQYLPSRYGMNPDHLRQADAIEVVLGQGAKPGGGGMLLGQKITERVAQMRTLPQGVDQRSASRHPDWTGPDDLTIKIGELREITDWEKPVYVKVGATRTYYDVKLAVHAGADVVVVDGMQGGTAATQEVFIEHVGIPTLAAIPQAVQALQELGVHRKVQLIVSGGIRTGADVAKAMALGADAVAIGTAALVALGDNDPRWQADYEALGTTAGAYDDFQEGRDPAGITTQDPELQQRLDPVEGGRRLANYLRVLTMEAQTIARACGKAHLQHLEPEDLVAITLEAAAMARVPLAGTSWIPGQTPGGSW
>NZ_CP011502.1|WP_067861205.1|416252_416942_+|protein-glxC
MAATLELDLAVSTLREVNARLHDPDLGADDVVVTHPAGRHSVAVGLNRPMTVTVKGHVGYYAAGMNQSADVVVEGNVGVGVAENMMSGSVWVKGSASQSAGATAHGGLLVVEGDAAARCGISMKGVDIVVGGSIGHMSAFMAQAGRLVVRGDAGDALGDSIYEARIYVRGTVASLGADCVAKEMRPEHHEELATLLKSAGYEDDDTHAYTRYGSARSLYHFHVDNTSAY
>NZ_CP011502.1|WP_067853951.1|415314_416211_+|glutamine-amidotransferase
MCGIVGLHLRNPDLYPRLGELLTGMLCEMEDRGADSAGVAVYGDPTWAPPGVATVSVLADGVDATTLAEQLTAAVGSDVDVTTAGPTLLVHGPVEASTLAAAVRATAPDALVIGFGEDLAVLKGVGRPRDLAATFGLPSAQGWQGVGHTRMATESAVTPAGSHPYAVGPDQCMVHNGSFHNYPTIRRELEARGVRFDSGNDTEVGARFVAQCLEDGLDVETALKELCRTFDGFYTLLVSNRDSFAVVRDAIACKPAVVAETDDWVAMASEYRALVGLPGIESARLFEPEPERIYAWTR
>NZ_CP011502.1|WP_067853949.1|413953_415276_+|type-III-glutamate--ammonia-ligase
MTSTASPLATLAKESETTFILALFVDLTGKPCAKLVPVEAVEELAREGVGFAGYAAGAMGQEPKDPDIMAIPDPASFTPVPFVKEGLALVHCDPHVEGEPWRFAPRVILRRMIERAAERDLSVYLGAEIEYFLVAKDERGALVTADPSDSAARPCYDARGVTRMFDHLASVSTAMNQLGWGNYANDHEDGNGQFEQNFDYADVLTTADRVITARYLISMLAEQRGMTATFMPKPFGDRTGSGLHMHLSLWKDDEPLFPAADDPRGLGLSELAYQAIAGVLEHASALQALVAPTVNSYKRTGAVATTSGASWAPRVPTYGGNDRTHLVRVPDGNRIELRGGDGSANPYLAAAGAIGAVLDGVERRLDPGAPGGSDDADRAPLPLTLLHAVEALEADPAVSGVLDSVGPDVARYFADLKREEFFTWHSQVSAWEVDHYLTAF
>NZ_CP011502.1|WP_067861203.1|412386_413631_-|ammonium-transporter
MDTGTTAFILSCIIGLTMMVPGLALFYGGMVSVKSSLNMMVMTFGAVAVVGILWVLFGYSMVFGDSYGGAGLLGNVTEYAGLGGVLTEKDTALPLALFAVFQALFAAITVAIISGAAADRMKFSSWMVFAAVWAVLVYFPVAHWVFAFDATDGSTVGGWIANKLKAVDYAGGTAVHINSGAAALAIAIVLGKRRTWGTAPRPHNLPLTLLGAGLLWAGWYAFNGGSALAAGHNASVVMLTTFVATCAAMLAWLGVEIVRDGHATTMGAASGAIAGLVAITPSCGAVSPMGAILVGVAGGIVCPLALGLKERFGYDDSLDVVGVHLVGGVVGTLMVGLIATADAPSGQAGLLHGGGLRLLGVQATAAGAVLAYSFVLTLVIALALKKTIGLRVDPDHEEGGLDSALPRERAYDLA
>NZ_CP011502.1|WP_067853947.1|411323_411794_-|hypothetical-protein
MRIRTLSTAAACAVVLMLAVGAVALTSLGDGGDPSAAAEPRPSTSSPTPTPRSTDPGSERDAKDDDSRDEREPDPDSDSDGDSDRDSAASSGRTPDRGATTPTTPRPTTPGATPTGPTTHSPRPTSPTQQPSPSPSPSSSPSPGMLDGLLDPIMGR
>NZ_CP011502.1|WP_067853944.1|410630_411320_+|helix-turn-helix-domain-containing-protein
MSDHRSVGRIVDLLDVVARADVPPTVSDLARRLDVPRSSVHDLVSGLEQRGWLLRAGRGLRIGPAPLVLELLAARHVSWTSVDADAYAERFDLAAAAAVLVGRHVVYTARSEKVVDERYAHVADLHLPRDPLTTAAGRLLLSAAPAQVLASVLDETRETDPGLVADYEAQLPLIRRRRTAWSDGLSQDEVAAVAVFPHRDRPEALVLFGRRVVDAARLTAAARTLARAS
>NZ_CP011502.1|WP_067853965.1|421576_422779_-|acetyl-CoA-C-acyltransferase
MPRAAIVATARTPIGKAYRGAFNDTPAVELAGHAVRHAVERAGVDPAEVEDVVMGCAMPEGASGFNVARQAALRAGLPVSVPGSTVDRQCSSGLMAVAIAAKQILVDGQRVAVGGGVESISLVQNEHLNTHRAGDPWLRERVPGLYLPMLHTAENVASRYGVSRERQDEMGLQSQLRAAAAQEAGHLAEEIAPITVHTLRTDRTTGETSRVEVTVSADEGVRAGTTAEGLAGLRTVLEPGDVTAHPTVTAGNASQLSDGASANVLMDADLAASRGIDPLGYYVGIAVTGCEPDEMGIGPVAAIPRLLDQHGLTVGDVGVWELNEAFASQAVHCRDVLGIDPERMNVDGGAIALGHPYGMTGSRAVGHALLAGRRLGARWVVVTMCVGGGMGAAGLFEVAL
>NZ_CP011502.1|WP_067853969.1|422914_424420_+|AMP-binding-protein
MVNVAATVWSNAERDPQRMAVRSGRGDLTYGELREASARVGGAVAAAGLRPGDRVVLIAPSIVEFPVLYLGLHAVGVSVITMNTMATAAEIGYVLDDAEASLVLAWHECDAAASAAAAERGTTFWRVEDGARFDADPLPAAHDHAPDDTAIILYTSGTTGRPKGVELTAANLIDTTDSFLPVLNLTAEDRFGTGLPLFHVYGQAVVMNTVLVTGASLSLLAPFEPTAMLEMVRRDRLTVLAGVPTMWNAMLHAATDAFGPSDFEQLRLATSGGASLPVEVMRAFRDRFGCTILEGYGLTESTGAATFNDINRPQKAGTVGPALPGTAIEVRDPLGAVVGPDVVGEVFLKGPTIMKGYRNRPDATAADLQDGWLKTGDLGRLDAEGYLSIVDRAKDLIIRGGYNVYPREVEEVLYEHPDVVEVAVVGVPDAHFGEEVAAVVALREGAELTGEELRSWAKVQLSAYKVPRLYQFVTTLPKGATGKILKREIDRDAIRTAEVGA
>NZ_CP011502.1|WP_067853974.1|424416_425226_+|SDR-family-oxidoreductase
MKVEGSVAVVTGAAGGIGLAVAQRLLEHGAHVVVTDLDAARTSAAVASLEPHGADRVAGLAGDCSLEADVQAVLDLAVERFGPVDLYVANAGVGLGQGLASSEEDWSTSLDVNVMAHVRAARLLVPGWLERGRGYFLSTASAAGLLTQIGSPTYSVTKHAAVAFAEWLSVTYGTRGIAVSCLCPMGVNTAMLNGGADSDDPTARQGARAVTEAGGVLEPLDVADVVLDAIDDERFLVLPHPEVLEFYRRKASDYDRWLAGMRRYQDTLA
>NZ_CP011502.1|WP_067853977.1|425222_425885_+|HAD-family-phosphatase
MSAATTPRCRAALFDFGGVLTTSVLDAFGDHSERISGDRGLLLRLFGGGDAKAKQLLVDHEEGRLDHDGFEAGLAERLRAHGVEVEAEGLVAGLQSGLRPDTAMLDVVADLRAAGVPVGLVSNSLGRDCYAGYDLPALFDAVTISGQEGVRKPSRRLYEIGCERLGVAPHEVVMVDDLAQNIVAAERLGMAGVVHREAEETAEQLSQLLGVDVRRTAALR
>NZ_CP011502.1|WP_067853982.1|425977_426955_+|sugar-ABC-transporter-substrate-binding-protein
MNVRRFGLGLVATAALVVTAACGSGDTGGSGGGGGDDTYTIGIVKFASSEETSEAAIAAFREEAEAKGWKTTAVDPQGAVEKANGAMQDFVQKKVDLIVTAVFDSKTLTAGAQAAKAAGIPVVSISGGTTDGITANLDSGVAVGAPVAKQLVEDMGGKGELLVMGYKSGLPCIGREEALDDALKGTDIKVTRNEVPIPGQVEGGTQFAQAWLAKHPKGSTPLAIWGCFDDPALGAVSAAKSAGRDDVKIYGINGTPAAIKAVEAGDMRATVFLQVPEAGTKFADMVPEFIKGGVDAEPQEVELPNILVTTDSVTQFLADNPDATK
>NZ_CP011502.1|WP_067853985.1|426959_428606_+|sugar-ABC-transporter-ATP-binding-protein
MTDTSSRVRPAGPTPTEHPQESLMVETTPLDGPTAPTVTEPPCLEMSGISKQFGGHQALEDVSIALHPGQVLALCGANGAGKSTLVRILAGVESADSGTIRVRGQEESIATPGDATRLGLSFIHQELNLVPKFTALQNIAMGADHTRRSGVLDLRGLRRKALAVMDRIGYAVPLDAKVEQLSVSDRWMVSLARSLMRDARIVAMDEPTASFTQEEADRLYGIVDELTADGVGILYISHRLEEVLHVSDDVTVLRNGRLVGSYAARDLDVASLTRHIVGRDVDDLTHRVTDTDPTTAPVLLQTSGLTREPRVRDVDLTIHEGEILGVAGLVGAGRTELARLLIGADPAQSGSMTLDGTPYRPRSPFDGIKAGVALVPEERRSQGLVLRSSVASNITMASMRDPRRRLGTFSPRRAAATARDAVTRFGVKTSSVHDAVGHLSGGNQQKVVVSKCVLTGPRLLILDEPTVGVDVGARGEIYDIIRDLAASGTSILMISSDFDELAICDRVVVMREGALTHSVPASRATKDHLTSLCFGTTEHLGTTEQDPS
>NZ_CP011502.1|WP_067853988.1|428602_429607_+|ABC-transporter-permease
MTAALVDVPVLQAPPRSARVWRWFGRYGALLVLALLVVGTSALEPETFATWDNFINILNQSALSAIIAMGLTFALVTGEFDLSIGNVASLSGVLACTAMVSHDVSIPVAFLLAVAIGAAVGLANGLVVTLLNVNALVATLGIGTVAVGINYAVAGGLPVSLTDPGPFIQITLGRFLGIPYPVFIMLGLAAALWFVLNRTVLGQSMQAVGGNPVAAQLSGIRVDRVRVVAFVICGICAALTGLLLASRTGSAAVSGGDTYLLAAFAAAFFGSAVLRDGEFHIIGTLVGVITVSVGFNAIALIGLETYWQYLFQGLLLILGVGVGSLARHRAAAAH
>NZ_CP011502.1|WP_067853993.1|429655_430465_+|enoyl-CoA-hydratase/isomerase-family-protein
MTDRPAAQHEELVLAERLGGVLLLTLHRPERLNAWTNALEDAYYGALLEADADPDVRAIVVTGAGRGFCAGADMEDLAGVGDATDEQIDRPHPRHLPLTLHTPLVAAVNGAAAGLGMVEALYADVRFASPRAVFLTAFAQRGLVAEYGMAWLLPRLVGHGRASDLLLSGRRVDGEEAARIGLVEHLVPADELVERAVAYAQGLATSCSPWSMATIKSQLLLDAERSFAESVRSADALMRESFRGSDIAEGVASFTERRPPVFAPLTKEI
>NZ_CP011502.1|WP_067853996.1|430464_431700_+|acyl-CoA-dehydrogenase-family-protein
MEFAPSQRSVEYQEKLLEFMDDYIYPAESIYAAQMAESGNPNFHPPILEELKTEARKRGLWNLFHPHEREDWGSPGLSNLDYAPLAEITGRSPYIAPEAINCNAPDTGNMEVLELFGTEEHKEKWLKPLLAGEINSAFCMTEPEVASSDATNVQLRMDADGDEYVLNGRKWFASNALHANCKVLIVMGKTNVEAATHRQQSMMVVPLDTPGITIVRGLPVFGYMDREGHAEILFEDVRVPKTALLAGEGDGFMISQARLGPGRIHHCMRSIGMAERALDLMIQRAQSRVTFGEPVANRSNIQDWIAEARIEIEMIRLLTLKTAWLMDTVGNQKARVEIAAIKVAAPQVALKIIDRAIQVHGGGGITDDFPLASFYAHQRTLRLADGPDEVHKRTLAQVELRRIDADWNKKK
>NZ_CP011502.1|WP_067853999.1|431696_432476_+|SDR-family-oxidoreductase
MTGSLDGRTAIVTGASRGIGLAAAAALHDAGANVVLTARTEEAAAEAAASVGPRAMGVGAHVTDEDLARACVERTMERFGSVDVLVNNAGTNPAYGPVLQQDHGRFAKTLDVNLWGPILWSRLVVDAWMGEHGGSIVNTASIGGLSVGPDLGVYHVSKAALIHLTKQLAIELGPGIRVNAVAPGVVRTRLAEALWKEHEAAVDDRTPLGRIGEPTDVGAAIAFLASPAASWITGETLVIDGGQMIGAGAALDRLATQGG

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Crispr_ID: NZ_CP011502_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_7

438240-438326

Orphan

Consensus_repeat	Method
CGTTTGCGTGGGGCCCCACGCAAACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011502_7

>merge|NZ_CP011502|7|438240-438326|CRISPRCasFinder
CGTTTGCGTGGGGCCCCACGCAAACGGGCTCGCCCCCACGCAACCATGCGCCGGATCTGCGCGTTTGCGTGGGGCCCCACGCAAACG

>NZ_CP011502|7|7|438240-438326|CRISPRCasFinder
CGTTTGCGTGGGGCCCCACGCAAACG	GGCTCGCCCCCACGCAACCATGCGCCGGATCTGCG
CGTTTGCGTGGGGCCCCACGCAAACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_083516186.1\|439312_440527_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP011502.1\|WP_067854011.1\|437263_438223_+\|phosphotriesterase	unknown	unknown	gnl\|CDD\|224649
NZ_CP011502.1\|WP_067854014.1\|438404_438857_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NZ_CP011502.1\|WP_067853988.1\|428602_429607_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119321
NZ_CP011502.1\|WP_067854008.1\|436608_437103_-\|MaoC-family-dehydratase	unknown	unknown	gnl\|CDD\|239534
NZ_CP011502.1\|WP_067854017.1\|440523_440862_+\|DUF1801-domain-containing-protein	unknown	unknown	gnl\|CDD\|227936
NZ_CP011502.1\|WP_067854020.1\|440969_442325_+\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NZ_CP011502.1\|WP_067854032.1\|448472_449216_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067854037.1\|449212_450262_+\|HTTM-domain-containing-protein	unknown	unknown	gnl\|CDD\|214802
NZ_CP011502.1\|WP_144433638.1\|446173_448369_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224276
NZ_CP011502.1\|WP_083516185.1\|434937_435609_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP011502.1\|WP_067854002.1\|434561_434870_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NZ_CP011502.1\|WP_067854040.1\|450258_451041_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067854005.1\|435610_436612_-\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176190
NZ_CP011502.1\|WP_067853996.1\|430464_431700_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173844
NZ_CP011502.1\|WP_067861210.1\|433608_434565_+\|cyclase-family-protein	unknown	unknown	gnl\|CDD\|377240
NZ_CP011502.1\|WP_067854023.1\|442341_444732_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP011502.1\|WP_158509165.1\|444999_446034_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|372282
NZ_CP011502.1\|WP_067853993.1\|429655_430465_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|180472
NZ_CP011502.1\|WP_067853999.1\|431696_432476_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235975

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_083516186.1\|439312_440527_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.63093e-49
NZ_CP011502.1\|WP_067854011.1\|437263_438223_+\|phosphotriesterase	gnl\|CDD\|224649	COG1735, Php, Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only].	3.28699e-100
NZ_CP011502.1\|WP_067854014.1\|438404_438857_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	9.25785e-25
NZ_CP011502.1\|WP_067853988.1\|428602_429607_+\|ABC-transporter-permease	gnl\|CDD\|119321	cd06579, TM_PBP1_transp_AraH_like, Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group also contains E. coli RbsC, AlsC, and MglC, which are TMs of other monosaccharide transporters, the ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also be involved in low affinity ribose transport. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Proteins in this subgroup have a single TM which homodimerizes to generate the transmembrane pore.	1.75077e-70
NZ_CP011502.1\|WP_067854008.1\|436608_437103_-\|MaoC-family-dehydratase	gnl\|CDD\|239534	cd03450, NodN, NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their legume hosts, a symbiotic process that requires production of Nod factors, which are signal molecules involved in root hair deformation and meristematic cell division. The nodulation gene products, including NodN, are involved in producing the Nod factors, however the role played by NodN is unclear.	4.62964e-80
NZ_CP011502.1\|WP_067854017.1\|440523_440862_+\|DUF1801-domain-containing-protein	gnl\|CDD\|227936	COG5649, COG5649, Uncharacterized conserved protein [Function unknown].	2.28945e-34
NZ_CP011502.1\|WP_067854020.1\|440969_442325_+\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	5.55788e-122
NZ_CP011502.1\|WP_067854037.1\|449212_450262_+\|HTTM-domain-containing-protein	gnl\|CDD\|214802	smart00752, HTTM, Horizontally Transferred TransMembrane Domain. Sequence analysis of vitamin K dependent gamma-carboxylases (VKGC) revealed the presence of a novel domain, HTTM (Horizontally Transferred TransMembrane) in its N-terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is more likely caused by horizontal gene transfer than by early invention. The conservation of VKGC catalytic sites indicates an enzymatic function also for the other family members.	9.1902e-39
NZ_CP011502.1\|WP_144433638.1\|446173_448369_+\|hypothetical-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	5.65702e-10
NZ_CP011502.1\|WP_083516185.1\|434937_435609_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.19001e-11
NZ_CP011502.1\|WP_067854002.1\|434561_434870_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	3.61087e-23
NZ_CP011502.1\|WP_067854005.1\|435610_436612_-\|NADP-dependent-oxidoreductase	gnl\|CDD\|176190	cd05288, PGDH, Prostaglandin dehydrogenases. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.	2.50158e-159
NZ_CP011502.1\|WP_067853996.1\|430464_431700_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	0
NZ_CP011502.1\|WP_067861210.1\|433608_434565_+\|cyclase-family-protein	gnl\|CDD\|377240	pfam04199, Cyclase, Putative cyclase. Proteins in this family are thought to be cyclase enzymes. They are found in proteins involved in antibiotic synthesis. However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site.	7.9587e-12
NZ_CP011502.1\|WP_067854023.1\|442341_444732_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	2.36991e-14
NZ_CP011502.1\|WP_158509165.1\|444999_446034_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|372282	pfam12740, Chlorophyllase2, Chlorophyllase enzyme. This family consists of several chlorophyllase and chlorophyllase-2 (EC:3.1.1.14) enzymes. Chlorophyllase (Chlase) is the first enzyme involved in chlorophyll (Chl) degradation and catalyzes the hydrolysis of an ester bond to yield chlorophyllide and phytol. The family includes both plant and Amphioxus members.	1.63092e-05
NZ_CP011502.1\|WP_067853993.1\|429655_430465_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|180472	PRK06210, PRK06210, enoyl-CoA hydratase; Provisional.	5.57168e-100
NZ_CP011502.1\|WP_067853999.1\|431696_432476_+\|SDR-family-oxidoreductase	gnl\|CDD\|235975	PRK07231, FabG-like, SDR family oxidoreductase.	2.48264e-111

>NZ_CP011502.1|WP_067854011.1|437263_438223_+|phosphotriesterase
MTTVQTVTGPIDSSELGRTLVHEHVFVLNTEYNQNYQDDWDEEERIRDAVEKLTELKALGIDSIMDPTVLGLGRYIPRIQRIAAQVDLQIVVATGLYTYNDVPHQFEHRGPGLLVDMPEPLTEMFVKDVQEGIAGTGVRAGILKCAIELAGLTPGVERVMRAVGQAHVQTGAPITVHTNPANESGLVAQRVLEEEGVDLSKVIIGHSGDTNDVDYLCRLADAGSMLGMDRFGLDLFNPMQERVGTIIELVRRGYVEHVTLAHDANCFIDYFSADAKAHAAPNWHFRHISEDVIPALLEGGLTEADVETILVDNPRRHFE
>NZ_CP011502.1|WP_067854008.1|436608_437103_-|MaoC-family-dehydratase
MTTTPAVPRPTSIQELQDLVGSDLGPTAWHDITQERIDAFAELTGDHQWIHVDPARAADSAFGGTIAHGLYSLSLGPRFMEDLMAFDGFAHSLNYGYEKVRFPAPLPVGSRIRMHATVVSVDDVGGGSAHIVTRQTFEREGSDKPICVAHSVGRFTEYPEGSGR
>NZ_CP011502.1|WP_067854005.1|435610_436612_-|NADP-dependent-oxidoreductase
MTVARQVRLRARPVGLPDAGTWDVVDTELPALGDGEVLVRVTHLSLDPAMRGWLNDVRSYVPPVGVGEVMRAFGVGTVLASRSPEHAVGDAVSGITGVADHAVLRGSDLSPVDLAVASAPTWLGALSMPGLTAWFGLFDVARARPGETVLVSGAAGAVGSVVGQLATAHGCRVIGIAGGPEKTRWLTDELGFDAAIDYREGAVHRAVRAIAPEGVDVYFDNVGGEVLDSALRTLRRGARIALCGAISTYNATEPAPGPAHYMSLLVNRASMTGFVVFDYEDRYPEAIADLSARLRDGSLVARETVVRGGVDAFGDTLLMLFDGGNTGKLVLEL
>NZ_CP011502.1|WP_083516185.1|434937_435609_+|TetR/AcrR-family-transcriptional-regulator
MTDRSATERLDEVPALADTSGMKEPPTTARGVRTRAALVAAARTVFERDGFLASRLTDITAEAKCSIGTFYTYFTSKEEVFTAVLEAAQDDMLHPGMPRVDDADDPVAVIEASNRAYFETYQRNGRLMRLQEQVATIDEDFRRRRLERGEAFARRNAKSIEKLQQDGRVDATLDPMMTSRALSGMVSRLAYSSFALGEDWPVDDLVETSTRLWANALGLTTPR
>NZ_CP011502.1|WP_067854002.1|434561_434870_+|antibiotic-biosynthesis-monooxygenase
MSALDVVATLEAQEGRGDELVAVLQASLATVRAEDGCLRYDLHRVRRRPDEVVMVERWASVDALKAHGAAEHFQRTSAQLADLLAAPPVVRVLEAVDVADPA
>NZ_CP011502.1|WP_067861210.1|433608_434565_+|cyclase-family-protein
MTETPYVGDFLKDSPRNWGKWGPDDEVGSLNYLTSAEVLRGVAEVRSGEVFTLQVRIGDPSGDPVWPGREGIQRSNVMDEGFFQRGEGVETPGGAHYSDDVATMYLQASTQYDSLGHVWYDGQIWNGYDAATTDGAMQKASVLPIAERGVVGRGVLLDVARHRGKAALDKGETFTHEDLLDVARAQGCTIEKHDVLVIRTGFIGSFYRQSAEEFYDGFLEPGLTYSPELVQWFQDMEIPNLVTDTIANEVTVEPSSGVTLPLHSALMRNLGVAFTEIAWLEDLAAACAADERWTFLYTAAPLKIVSGTGAPVNPVVVR
>NZ_CP011502.1|WP_067853999.1|431696_432476_+|SDR-family-oxidoreductase
MTGSLDGRTAIVTGASRGIGLAAAAALHDAGANVVLTARTEEAAAEAAASVGPRAMGVGAHVTDEDLARACVERTMERFGSVDVLVNNAGTNPAYGPVLQQDHGRFAKTLDVNLWGPILWSRLVVDAWMGEHGGSIVNTASIGGLSVGPDLGVYHVSKAALIHLTKQLAIELGPGIRVNAVAPGVVRTRLAEALWKEHEAAVDDRTPLGRIGEPTDVGAAIAFLASPAASWITGETLVIDGGQMIGAGAALDRLATQGG
>NZ_CP011502.1|WP_067853996.1|430464_431700_+|acyl-CoA-dehydrogenase-family-protein
MEFAPSQRSVEYQEKLLEFMDDYIYPAESIYAAQMAESGNPNFHPPILEELKTEARKRGLWNLFHPHEREDWGSPGLSNLDYAPLAEITGRSPYIAPEAINCNAPDTGNMEVLELFGTEEHKEKWLKPLLAGEINSAFCMTEPEVASSDATNVQLRMDADGDEYVLNGRKWFASNALHANCKVLIVMGKTNVEAATHRQQSMMVVPLDTPGITIVRGLPVFGYMDREGHAEILFEDVRVPKTALLAGEGDGFMISQARLGPGRIHHCMRSIGMAERALDLMIQRAQSRVTFGEPVANRSNIQDWIAEARIEIEMIRLLTLKTAWLMDTVGNQKARVEIAAIKVAAPQVALKIIDRAIQVHGGGGITDDFPLASFYAHQRTLRLADGPDEVHKRTLAQVELRRIDADWNKKK
>NZ_CP011502.1|WP_067853993.1|429655_430465_+|enoyl-CoA-hydratase/isomerase-family-protein
MTDRPAAQHEELVLAERLGGVLLLTLHRPERLNAWTNALEDAYYGALLEADADPDVRAIVVTGAGRGFCAGADMEDLAGVGDATDEQIDRPHPRHLPLTLHTPLVAAVNGAAAGLGMVEALYADVRFASPRAVFLTAFAQRGLVAEYGMAWLLPRLVGHGRASDLLLSGRRVDGEEAARIGLVEHLVPADELVERAVAYAQGLATSCSPWSMATIKSQLLLDAERSFAESVRSADALMRESFRGSDIAEGVASFTERRPPVFAPLTKEI
>NZ_CP011502.1|WP_067853988.1|428602_429607_+|ABC-transporter-permease
MTAALVDVPVLQAPPRSARVWRWFGRYGALLVLALLVVGTSALEPETFATWDNFINILNQSALSAIIAMGLTFALVTGEFDLSIGNVASLSGVLACTAMVSHDVSIPVAFLLAVAIGAAVGLANGLVVTLLNVNALVATLGIGTVAVGINYAVAGGLPVSLTDPGPFIQITLGRFLGIPYPVFIMLGLAAALWFVLNRTVLGQSMQAVGGNPVAAQLSGIRVDRVRVVAFVICGICAALTGLLLASRTGSAAVSGGDTYLLAAFAAAFFGSAVLRDGEFHIIGTLVGVITVSVGFNAIALIGLETYWQYLFQGLLLILGVGVGSLARHRAAAAH
>NZ_CP011502.1|WP_067854014.1|438404_438857_-|C40-family-peptidase
MRHVTRALGVAMLLLSLSFGTTLAAGSASALTPQENKKVMKIAKSLRGTPYKWGGTSRSGFDCTGYTRYVFRKAHVTTLGRTAGQQAKQGIKISKYRKRVGDLIVFYGGNGAYHVGIYAGDNTIWHSPRTGQSVKRERIWTSSYKVRRMG
>NZ_CP011502.1|WP_083516186.1|439312_440527_+|GGDEF-domain-containing-protein
MLDVVSLRVSFAVVAVTLLALFYFVAYRSTRSAYAGWWCVALGAFLAGSAAYLLDGTSQQWWGNPLGNVCIVAGAASVWAGARAVSGLRVSWLAVAASLVVLLVASALDHPGRNDWSGGPFFLGLMTVYLALAATELHRAWRRLPAPGPRARVYRPILRSLTLMCTGVAAFYLARFVAFLAVGQDGRLFDVFLGSQVTTLVTTVMLATVSFSMTALSYADDTIDLRARATRDGLTGLLNRDELMQQLAQRWNAHRRRAVHGVVVMADLDHFKRVNDVHGHAAGDFALQMFAAACRSALGPEDLAGRVGGEEFVLYLDRADLDDARQAVEQVSSMLQHGSLPDGTVLPTVSYGLTVARRGDDPDVAIGRADRALYVAKSEGRDRVAVADGDEKAPAAPRPPTIAP
>NZ_CP011502.1|WP_067854017.1|440523_440862_+|DUF1801-domain-containing-protein
MSDWRADRVQQVRDLVRAAAPDAVEEVKWRKPSNPDGVPTFSCDGLLCTVETYKDKVKVTFARGASLDDPAHVFNASLDAGTRRAVDLREDDTLDADAFTALVSAAVAHNRA
>NZ_CP011502.1|WP_067854020.1|440969_442325_+|HlyC/CorC-family-transporter
MDTGTLLNLALVMVFVLVGGVFAATELALVSLRESQLGQMERSGSRGRKVAELARDPNTFLAAVQIGVTVAGFLSAAYGASTLAPDVAPSLEALGLSPGAASSLALVGMTLLIAYLSLVFGELVPKRFALQKSGTIALLVAPPLSRFATLMRPVIWLLSLSTNVLVRLLGGNPHATSEEMTEDELRDLVGAHESLEDDERQILQDVFTATDRTLREVMRPRGAVDFLDGGMSLAEAAGAALAMPHSRYPVTRRRSSDDVIGFVHVRDLLAVPTDSDAKVVADIVREIPVLPSTNRILPAMAQMRSEGVHIALVVDEYGGTDGIVTLEDIIEELVGEIRDEYDLAEKAELLHSPEGDDLDAGMHLDDLEELTGLELLHESGHYSTVAGLVLERLGHIPQVGETVDIGPYRLTVTAVDGRRIDRVTLTTRPSDEPSADGADVEAERPDGDERR
>NZ_CP011502.1|WP_067854023.1|442341_444732_-|LuxR-family-transcriptional-regulator
MTTALEEGRSIEIRGRRLSGRTTLLDRLGELSTSRRVPHRRVEGSEPLRDHPFGALLISGLLESATLAGPNPLRAAVEAVRRRLPSSGPAALLVDDADHLDAQSVAVLRHLERRGLVVAAAYRTDLAGRAAPRVVSGAPVVVDAPSLAPSSLLSTLRERLGGAVSARLLSEVFALSGGVVGVAEHLVDDGVFDGSITQVDGAWDLRGPLVSRSLDGLWQAFLRELPPADCHWLTTLATAGRSTLGTLPPAALDAVDRLESLGHVRTVRRGDGRAVLVSALLAEHVRRTSDAVARSASPPMWVPPVEVDGPAPGCVVGPVPRELGWRAQLVRQAAAPDPHDLSTQLVSGGTAEAPTLARVLGLAERSTRLTSDLSLLTSAREHLARLDDGSDDVRLALAAATTVLEVVAGVAHRHEPPADDPGAHALARAKACEARLYDALATGRFTATDDDLALASTLADESGDVVRLVPRLRGLQSLVTAFRGDLRTTRALVTQTVDDAVASGRLDQVAYVGSSVGVLMLVGGQLGLARRYVETALALPWEGAAQDSVSTPQLAAVLSLWDDDPALASALHTWAPDGPELGPDPYDTAAWRHTAVLRSSGRPEAASETLLDHAEDARRRGWLSTAAILAIHARDICSTPRSRELAETCSGTVDSPLTALYFRAIAARDACDVEAMTSLRHDMLEHGAVVGAYRLTLAASRLAPPGASARALAAELGELRRLHPEAVFVAERTTTGPSLTAREREVVMAVLQGRSNAEVAREQFVSVRTVESHLHRAMKKLGVTRRSELRGLVDLL
>NZ_CP011502.1|WP_158509165.1|444999_446034_+|alpha/beta-fold-hydrolase
MGMTARIVRRAVSVAVVAALAVGVATPPASADVAGAVASERGDATSVYADGPGPYEVASTAALGDCRLVQRWILQLAIGDADPRCSDAFPYGFDQPISSVVYYPHGVPGDGRLPVVDFVGGIFSDVGNYDTLARHWASHGFVVTVSSDFVNSGPEMHLLGLATARRLDADPTSPLHDRVDLGRVVLAGHSAGGAAALQAASVPADLLTRLDPRLRVSGTLAVEPGPGALGSTVRTPVLVLAGARDATVPAGSWPLLTQSGLVRSVPGWFATARTADHFSPVRTNLADDEFAGITTAYLLYRGTGDAEASTFFEGPDYRLARDTTFITHPLNPLRVRRNAAAGAL
>NZ_CP011502.1|WP_144433638.1|446173_448369_+|hypothetical-protein
MTQDLRRQRRQRRRRTTIAGTALMGLGLTMAAQSAMAGDEPGGFSGAVRNYGVFAGASLLDNRINLRANVAEGVAVADSAGLSPYQGTGVGSYAVPSTIANDPESRSYARASPIGAGAVGLNLQIVKAESAATTVVDGQRDDQDFGNLTIPTLGSLEALTGAAEARWNAQTVAQGGRLSYAETNTGKLTLIDPTLGFPLPGSIFPVGEADLGQNTSEVSLVPDSAVCPDGLALQSEATWNFADVQLFDGLVAVSWGGDAGGPDDIARIVAKANGKPAGATLEVPELPDMQIKIGDAALKLEPGLSIELSQVFNGSPVGESLSRLVDGELNYGGITNVVEASDGTHAAGSMNGLTADLTIAPIPGVAPNGLGSAELGFERVDVDAKAASGGINCTGGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGTDNSGRDNSGTDNSGRDNSGTDNSGRDNSGTDNSGRDNSGTDNSGRDSSGADSSGASTSGDDDTGGTSGADTSGAGQSAGKDQIAGGANGIGFSASASGISSGAVGGPRGGYLPNTGGPVSVPLLLWGLALTALGGATLVAGRRGRGARA
>NZ_CP011502.1|WP_067854032.1|448472_449216_+|hypothetical-protein
MTSDPQQPARPLPRGVRRVLVAVAVAAVAHTMVVALWILPDNLVTEQVSGRWLDAYIEPFFEQSWSVFAPIPKRGTIDLEVRGRDGDGWTSPWVSLTAPERDQIRYSLAPSRSALLTQTLAGSLNGAYGALSDDQRDVVSQHETARTLRKALFAADGEPAAARRYLRTDGVLEQLASVAAQTLWDGKATQVELRTVRRQVVEYGTAQDGRRTVTFRPVRYGWRNVVSVPQPDRGVLQDHLARVGVRP
>NZ_CP011502.1|WP_067854037.1|449212_450262_+|HTTM-domain-containing-protein
MRAVGQRRIDQRRETSRVAEVVDRLCTQPYGLHSLAACRILLGTMYVGVLLSNLRDRRLLWGPGSSWMTPLREGYGFDGWLVGLQHLSGGWFDLFYLAVLAAAVCFTLGRLTRTAGLLLLLGSIQLVESAPFLGDQGDNIARIGLFYLLWTRCSVVWSWDARLRWGGMDSTLQYLVWTRLGLARVLDRDAARAVGTFVSNVALGLLMAQIVMVYVTAGLYKARGGPWQFGTALYYPLSLPEFRPFGFLNDLLVAQPVLLALATWSVVLLQVLFPLTLPWAPARRVALVGIAGMHLGIALLMGLPWFSLSMLAFDTLFVSERTLLRVQAFAVDRWDDLVIAVQSRVRRTA
>NZ_CP011502.1|WP_067854040.1|450258_451041_+|hypothetical-protein
MTRRASRARSVLAAAALVLLAGLCLTGCSGRDDDAARERHPVPKADASTASREATPSASAMTDPHVGAALERLRAASRAAHVAGATRMTGSSSTAGERGTVRATGDLRSGAWEATVRAPRTRLEVRSRYNTTWVHADRTFWLRSGYTPASARAGARGWVLMERSAGDRLRDQLDPGRVLGRAAALRPADVARVRADEDRYEVVLDDDSGARTTFVVTRRGTPVLRSVRLRGEGVRADFDLRLLREPVVVATPRPDEVVRP

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Crispr_ID: NZ_CP011502_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_8

667474-667558

Orphan

Consensus_repeat	Method
GTTTGCGTGGGGCCCCACGCAAAC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP011502_8

>merge|NZ_CP011502|8|667474-667558|CRISPRCasFinder
GTTTGCGTGGGGCCCCACGCAAACAGGCTCCGCCCACCGCAGACATGCGGCGTGAGTGCACGTTTGCGTGGGGCCCCACGCAAAC

>NZ_CP011502|8|8|667474-667558|CRISPRCasFinder
GTTTGCGTGGGGCCCCACGCAAAC	AGGCTCCGCCCACCGCAGACATGCGGCGTGAGTGCAC
GTTTGCGTGGGGCCCCACGCAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_083516563.1\|655875_656895_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236108
NZ_CP011502.1\|WP_067861286.1\|667665_668010_+\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NZ_CP011502.1\|WP_067854609.1\|671370_672234_+\|NADH-quinone-oxidoreductase-subunit-NuoE	unknown	unknown	gnl\|CDD\|181024
NZ_CP011502.1\|WP_067854603.1\|669087_669858_+\|NADH-quinone-oxidoreductase-subunit-C	unknown	unknown	gnl\|CDD\|181115
NZ_CP011502.1\|WP_067861288.1\|668174_668534_+\|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl\|CDD\|181171
NZ_CP011502.1\|WP_067854587.1\|660570_662166_+\|choline-dehydrogenase	unknown	unknown	gnl\|CDD\|235000
NZ_CP011502.1\|WP_067854606.1\|670036_671374_+\|NADH-quinone-oxidoreductase-subunit-D	unknown	unknown	gnl\|CDD\|180385
NZ_CP011502.1\|WP_067854592.1\|663773_665042_-\|isochorismate-synthase	unknown	unknown	gnl\|CDD\|224091
NZ_CP011502.1\|WP_067854600.1\|668533_669088_+\|NADH-quinone-oxidoreductase-subunit-B	unknown	unknown	gnl\|CDD\|235797
NZ_CP011502.1\|WP_067854579.1\|655645_655852_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067854620.1\|677272_677863_+\|NADH-quinone-oxidoreductase-subunit-NuoI	unknown	unknown	gnl\|CDD\|235637
NZ_CP011502.1\|WP_083516220.1\|657893_658844_+\|o-succinylbenzoate-synthase	unknown	unknown	gnl\|CDD\|235084
NZ_CP011502.1\|WP_067854617.1\|676022_677276_+\|NADH-quinone-oxidoreductase-subunit-NuoH	unknown	unknown	gnl\|CDD\|235692
NZ_CP011502.1\|WP_067854611.1\|672226_673537_+\|NADH-quinone-oxidoreductase-subunit-NuoF	unknown	unknown	gnl\|CDD\|131014
NZ_CP011502.1\|WP_067854576.1\|654705_655596_-\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	unknown	unknown	gnl\|CDD\|235695
NZ_CP011502.1\|WP_067854595.1\|665074_665767_+\|demethylmenaquinone-methyltransferase	unknown	unknown	gnl\|CDD\|234689
NZ_CP011502.1\|WP_067854582.1\|657134_657788_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NZ_CP011502.1\|WP_067854584.1\|658840_660442_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236020
NZ_CP011502.1\|WP_067854614.1\|673533_676026_+\|NADH-quinone-oxidoreductase-subunit-G	unknown	unknown	gnl\|CDD\|236118
NZ_CP011502.1\|WP_067854590.1\|662162_663707_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143417

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_083516563.1\|655875_656895_+\|AMP-binding-protein	gnl\|CDD\|236108	PRK07824, PRK07824, o-succinylbenzoate--CoA ligase.	1.49634e-96
NZ_CP011502.1\|WP_067861286.1\|667665_668010_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	3.50247e-13
NZ_CP011502.1\|WP_067854603.1\|669087_669858_+\|NADH-quinone-oxidoreductase-subunit-C	gnl\|CDD\|181115	PRK07785, PRK07785, NADH dehydrogenase subunit C; Provisional.	7.60817e-141
NZ_CP011502.1\|WP_067854595.1\|665074_665767_+\|demethylmenaquinone-methyltransferase	gnl\|CDD\|234689	PRK00216, ubiE, bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE.	1.05702e-119
NZ_CP011502.1\|WP_067854587.1\|660570_662166_+\|choline-dehydrogenase	gnl\|CDD\|235000	PRK02106, PRK02106, choline dehydrogenase; Validated.	0
NZ_CP011502.1\|WP_067854606.1\|670036_671374_+\|NADH-quinone-oxidoreductase-subunit-D	gnl\|CDD\|180385	PRK06075, PRK06075, NADH-quinone oxidoreductase subunit D.	0
NZ_CP011502.1\|WP_067854592.1\|663773_665042_-\|isochorismate-synthase	gnl\|CDD\|224091	COG1169, MenF, Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	8.43202e-97
NZ_CP011502.1\|WP_067854600.1\|668533_669088_+\|NADH-quinone-oxidoreductase-subunit-B	gnl\|CDD\|235797	PRK06411, PRK06411, NADH-quinone oxidoreductase subunit NuoB.	1.34178e-100
NZ_CP011502.1\|WP_067854609.1\|671370_672234_+\|NADH-quinone-oxidoreductase-subunit-NuoE	gnl\|CDD\|181024	PRK07539, PRK07539, NADH-quinone oxidoreductase subunit NuoE.	6.01733e-75
NZ_CP011502.1\|WP_067854620.1\|677272_677863_+\|NADH-quinone-oxidoreductase-subunit-NuoI	gnl\|CDD\|235637	PRK05888, PRK05888, NADH-quinone oxidoreductase subunit NuoI.	3.93935e-80
NZ_CP011502.1\|WP_083516220.1\|657893_658844_+\|o-succinylbenzoate-synthase	gnl\|CDD\|235084	PRK02901, PRK02901, O-succinylbenzoate synthase; Provisional.	5.66002e-149
NZ_CP011502.1\|WP_067854617.1\|676022_677276_+\|NADH-quinone-oxidoreductase-subunit-NuoH	gnl\|CDD\|235692	PRK06076, PRK06076, NADH-quinone oxidoreductase subunit NuoH.	1.62388e-168
NZ_CP011502.1\|WP_067854611.1\|672226_673537_+\|NADH-quinone-oxidoreductase-subunit-NuoF	gnl\|CDD\|131014	TIGR01959, NADH-quinone_oxidoreductase_subunit_F, NADH-quinone oxidoreductase, F subunit. This model describes the F chain of complexes that resemble NADH-quinone oxidoreductases. The electron acceptor is a quinone, ubiquinone, in mitochondria and most bacteria, including Escherichia coli, where the recommended gene symbol is nuoF. This family does not have any members in chloroplast or cyanobacteria, where the quinone may be plastoquinone and NADH may be replaced by NADPH, nor in Methanosarcina, where NADH is replaced by F420H2. [Energy metabolism, Electron transport].	0
NZ_CP011502.1\|WP_067854576.1\|654705_655596_-\|1,4-dihydroxy-2-naphthoate-polyprenyltransferase	gnl\|CDD\|235695	PRK06080, PRK06080, 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated.	1.24872e-113
NZ_CP011502.1\|WP_067861288.1\|668174_668534_+\|NADH-quinone-oxidoreductase-subunit-A	gnl\|CDD\|181171	PRK07928, PRK07928, NADH dehydrogenase subunit A; Validated.	2.1433e-61
NZ_CP011502.1\|WP_067854582.1\|657134_657788_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.51304e-53
NZ_CP011502.1\|WP_067854584.1\|658840_660442_+\|hypothetical-protein	gnl\|CDD\|236020	PRK07449, PRK07449, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Validated.	1.40467e-149
NZ_CP011502.1\|WP_067854614.1\|673533_676026_+\|NADH-quinone-oxidoreductase-subunit-G	gnl\|CDD\|236118	PRK07860, PRK07860, NADH dehydrogenase subunit G; Validated.	0
NZ_CP011502.1\|WP_067854590.1\|662162_663707_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143417	cd07099, ALDH_DDALDH, Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like. The 4,4'-diapolycopene-dialdehyde dehydrogenase (DDALDH) involved in C30 carotenoid synthesis in Methylomonas sp. strain 16a and other similar sequences are present in this CD. DDALDH converts 4,4'-diapolycopene-dialdehyde into 4,4'-diapolycopene-diacid.	0

>NZ_CP011502.1|WP_067854595.1|665074_665767_+|demethylmenaquinone-methyltransferase
MSRAGLDKEPRDVARMFDTVAQRYDVTNDVLSLGQDRRWRRKVVDLVAPKPGERILDLAAGTGTSSEPFREAGATVVPCDFSLGMLQEGRRRFAHLPFVAGDGMRLPFADASFDAVTISFGLRNIHDPLQGLRELRRVTRPGGRIVVCEFSTPTWEPFAAVYSNYLMRALPSIARRTSSNPESYVYLAESIRAWPDQKGLALRMVEAGWGRVEWHNLSGGIVALHHSFRP
>NZ_CP011502.1|WP_067854592.1|663773_665042_-|isochorismate-synthase
MTSPPPVAAAASPLPSPLVARTVEVDDPGPLLALLHRDTDAVAWVHHGDGLVGWGRAASLSVDGPDRFDRAHRWWREVTRHSVTRDEVHVPGSGLVAFGSFAFADDGRGSSLVVPEVVVGRRDGRSWVTVVGTSISSPPSLTPTDPPQHPHGVELVDGSVDSDAWQDVVAEAVRRISAGQLDKVVLARDLVAELDTPLDVRSPLRRLARDYPGCWTFHVDGFFGSTPEMLVRLERGLVTSRVLAGTIRRTGDDTRDLALAASLARSSKDLEEHEYAVRSVAEALAPHCSSTNVPDAPFVLHLPNVMHLATDVTAVLRGDASALNLVAALHPSAAVGGTPTDAAVALIAEIEGLDRGRYAGPVGWIGAEGDGEWGIGLRSAQLEDEGRRVRLFAGCGIVADSVPADELAESQAKLVPVRDALA
>NZ_CP011502.1|WP_067854590.1|662162_663707_+|aldehyde-dehydrogenase-family-protein
MTSTFDRHPSPPPTSASVPADGVETFESLDPATGDLVGVHPVAGPEDVALAVERARDAAAWWGNLTFDERAEHLLTWRSVITRRIAQLSELSHRETGKPIPDAQLEIALAIDHVAWAAKHAKKVLGPQRVASGLVMANQKSTVEYKPLGVVGVIGPWNYPVFTPMGSIAYALAAGNTVVFKPSEYTPGVGVWLAETFAEVVGGIPVLQAITGLGATGAALCTSGVDKLAFTGSTATGKKVMAACAERLTPVVIEAGGKDSLIVDEDANIAKAAEAALWGGMSNAGQTCIGTERVYVHEKVFDAFVAEITEQAKGLRAGTDAGAKIGPITMPSQVDVIRGHVQDALDRGATAVVGGADAVGERFVQPTILTHVPETSTAITEETFGPTLAINPVRDMDEAVRLTNAGKYGLAGAVFSKRHGVEIARRIRSGMTSVNGIITFAGVPGLPFGGVGESGFGRIHGPDGLKEFTYAKAITRQRYAPPLNLTSFKRTVKDEKGLNLIVTLLHGGKKTLKP
>NZ_CP011502.1|WP_067854587.1|660570_662166_+|choline-dehydrogenase
MGIETFDYVVIGSGSGGGVVAARLTEDPDVRVLLLEAGPMDDDDMIHLPAGFSTLFKTSWDWGYQTTPQKHLGNRRADWPRMKALGGCTSMNAMIYIRGNHADYDEWRDAYGADGWGYDDVLPYFVRSEGNQRLRNSFHGNDGPLHVEDRRHDHELSHAFVESAVANGMKRTDDFNGAEQEGAGLYQVTCRKGRRWSVADAYIRPALSRPNLVLRTEAFVTSIDLEGAKGAKRAVGVTYRRGAFTETVRVNAEVVLAGGAINSPQLLMVSGIGPTAHLKDHGIDVQVDLPGVGQNLQDHPVSGVLAHTQGTTDIAASLNLPQLLKAQKLGRGPLTSNVAEAGAFFTSRDDLDLPDLQFHFAPTGFWDNGLHEPTQPALTLAATLVRVQSRGHVRLRSADPSWKPEIEAGYLDDRADLEALAAGIRRACEILKDGPLARYVKAPWEPASLDPTDDQVYASINRLCQTLYHPVATCAMGTGDESVVDPQLRVRGVEGLRVADASVMPAVPRGNTNAPTIMVGEKAADLLKESR
>NZ_CP011502.1|WP_067854584.1|658840_660442_+|hypothetical-protein
MSEQRSIGVARRLLHALLGHHVTDVVLAPGSRSAPLALAFHAAEQAGRIRLHVRVDEREAGFLALGLARTSHRVVPVVTTSGTAVANLHPAMLEALHAGVGVLAVTADRPARLRGTGANQTTVQPGIFPGVAYTDRVKGLLGVARPDAPGHLNLELDEPLVESVDWSLDRDPDALMLGRVGSWREPGVLTTLDLGPRTVVLAGDDSGARARVLAREAGWPLLAEPTSGSRTGGALSTYRLLLGHEPLAGRVERVVSFGHPTLSRPVTRLLARADVDVVHVGTQATFPVPAGPRVTFVDDVAAGSVDDPAWLQEWTDADARVQRAVDALLADHPDSGLAVARTVAEALPPDGLLVVGASQPIRDLDVVARPWTVGERRYVVANRGLAGIDGTVSTAVGAALARDSSWALALMGDLTFLHGSNGMLIGPDEPRPDLTVVVVNDDGGAIFSTLEQGGPEHADAFERVFATPTGADLGALCAGYRVAHRRVEPAGLAAALALPTGGLEVVEVVLRRDDRRALDAALRSATAAALADD
>NZ_CP011502.1|WP_083516220.1|657893_658844_+|o-succinylbenzoate-synthase
MHTFAIGMPVRFRGIHRREGLLMRGAAGWGEFSPFLDYDDEECVPWLRAALEAAHDGWPEPVRDRVPVNATVPAVGPEQAAQIVRTSGASTAKVKVAERGQTLADDVARVEAVRDVLGSGGRVRVDANGGWSVDDAVAAVKALDAVGTLEYVEQPCASVEELALVRRRVDVPVAADESIRRAADPYRVRDLEAADVAVLKVQPLGGVRACLRVAEEIGLPVVVSSAVESSVGLAAGVALAAALPELPYACGLGTTSLLGGDVTSSPLDPVDGWLPVRTVDVEEAALADVAADAATDAAWRARFERVDALRRAAVAR
>NZ_CP011502.1|WP_067854582.1|657134_657788_-|SDR-family-oxidoreductase
MSTIAIVGGHGQIALHLIEQLRARDHDVVALIRNDAHTSDVEQRGATARRLDIEQQDADAFASVFDGCDAVVFAAGGGPDGNIGRKRAVDLEGSLKSIEGARIAGVRRFVQVSAIGVDLPLPEDTDDVWRAYVEAKRDADVALRESGLDWTIIRPGRLTDDPARGSVTLGDSVARGEVPRADVAAVIAEVLHTGAGIGRQWDLVTGETPLDEAVASA
>NZ_CP011502.1|WP_083516563.1|655875_656895_+|AMP-binding-protein
MSGSARDVLDLLRPWVAGDDVEPLVVRTSGSTGEPKDVRLSRDAVLASAHATHARLGGPGQWLLALPVTGVGGLQVLVRSLLAEQEPVLLDDHDDLVDALRELDAPRTYASLVPTQLHRLASAGRLDVLAALDAVLVGGAALDPTLREQATSAGVRVVRTYGMSETSGGCVYDGVPLDGVRVRVADARDGVGRVQLAGPVLFDGYGDVARTDEWFDTADLGSVDAAGVLSVVGRADDVVVSGGVNVPLPAVERALRALPEVNDAAVAGVPDDEWGTRVVAVVVPADATCLDAVAADRLRDALEEQGLPRRWAPRDVTLVDTVPLLPNGKVDRLAVRRLF
>NZ_CP011502.1|WP_067854579.1|655645_655852_+|hypothetical-protein
MTQPPFPFVLVLLTGIFVWLAVTSDGGWLPLAAGFGALVTGAAALYQSRPVRDPLEEEPESEEWEPGS
>NZ_CP011502.1|WP_067854576.1|654705_655596_-|1,4-dihydroxy-2-naphthoate-polyprenyltransferase
MNDRSSATLSQWVEGARPRTLPAAVAPVLAGTGVAAYVADVVWGKALLALGVSLALQIGVNYANDYSDGIRGTDDDRVGPLRLVGSGLARPSAVKAAALGFLGLGALLGLALAATTTWWLLLVGVAALGAAWTYTGGPNPYGYRALGEVSVFLFFGLVAVLGTVYVQVEGLPWEAWAAAVGVGALACAILVANNLRDIPTDVEAGKRTLAVVLGDARSRQFYAALVGLSAALAVALAVGATPWALLALPGLLPAVPALRAVLSGAGGPALVPVLKATGVAELLWSAGLALGLVLGR
>NZ_CP011502.1|WP_067861286.1|667665_668010_+|helix-turn-helix-transcriptional-regulator
MEPAPSLRHDVEPTPERLAEASEVFGLLSDRTRLHLLWVLARQDADVTTLADTVGASRTSVSQHLAKLRLAGLVEAHREGRRVRYTLVGGHLRRLLLEALGHADHVVTGEPHHV
>NZ_CP011502.1|WP_067861288.1|668174_668534_+|NADH-quinone-oxidoreductase-subunit-A
MNEYTPVLVLGALAAGFAVFSIAIAPLTGPKRYNRAKLDRYESGIEPSPLPDGGGKVSVKYFFTAMMFIVFDIEIVFLYPFAVAFDQMSWFAVFAILLFLVNVTIAYAYEWRRGGMEWT
>NZ_CP011502.1|WP_067854600.1|668533_669088_+|NADH-quinone-oxidoreductase-subunit-B
MGLEEKLPSGVLLSTVEGLAGYMRKASFWPATFGLACCAIEMMTFGAPRFDSSRFGMEVFRPSPRQADLMIVAGRVSNKMAPVLRQIYDQMAEPKYVLAMGVCASSGGMFNNYAIVQGVDHVVPVDMYLPGCPPRPEMLIDAILKLHDKIQHTKLGAHRLEEIRADEAAALDAAPTSALKGLMR
>NZ_CP011502.1|WP_067854603.1|669087_669858_+|NADH-quinone-oxidoreductase-subunit-C
MADDKTRTVDDHTTTQDRSHDPVPDGGAPVVPAGTETFEVVDVRQGMFGVRGTGDTSGYGGITRPVAMPPASQPPFGPGDGPGWFDDVHDRLAELADGTDAIERVVVDRGEITFVVRRETLLDVVRHLRDDAALRYELCSSLSAVHFPHETGRELHVVLHLLSMTHRRRIRVETTCPDADPHVPSVVAVYPTADWQEREAYDMFGIVFDGHPALTRILMPDDWQGHPQRKDYPLGGIPVEYKGGTVPSPDQRRSYS
>NZ_CP011502.1|WP_067854606.1|670036_671374_+|NADH-quinone-oxidoreductase-subunit-D
MTDTTHDAYAGTSETTSGPVFTVTGQDWDTVDAAAVDGDRIVVNMGPQHPSTHGVLRLILEIDGETVKDARPGIGYLHTGIEKNMEYRTWTQGVTFCTRMDYVAPFSNEAAYVAAVERLLGVEDDVPERARTIRVLMLELNRISSHLVCIATGGMELGALTVMTCGFRDRELILDLFEAISGLRMNHAYLRPGGVAQDLPDGVVEQLRGTVALLRKRLPEYAALCNANPIFKGRLKGVGHLELDGCLALGLTGPVLRATGYDWDLRRTQPYWGYDTYDFDVVTWDEPDAYGRFRVRLEEMRQSLRIVEQAIDRLEDTAGAPVMVDDPKIAWPARLSVGSDGQGNSAEHIRHIMGESMEALIHHFKLVTEGFRVPPGQAYAAIEAPRGEIGCHAVSDGGTRPYRVHFRDPSFVNLQGTSIMSEGGMLSDVIVAIASIDPVMGGVDR
>NZ_CP011502.1|WP_067854609.1|671370_672234_+|NADH-quinone-oxidoreductase-subunit-NuoE
MSQGVTPPLDEATTAELRELMGRYPQARSALLPMLHLVQSVQGSVTSEGVETCAELLGLTTAEVSGVATFYTMYKRRTMGTHHVGVCTNTLCAVMGGDAIFERLSDHLDVGNDETTADGQVTLERIECNAACDYAPVLTVNWEFLDRQTPESAVDLVDRLRAGEPVQASRGATITSWRDAERVLAGFEDGRADEGPSAGDASLAGLRIAQERGWSAPPIPPVADTGTQDHGPGGGSGPRAEKEPGGGSGPWAEKDTAEAEADTRRAEDETVAEESAADVKGGGSADG
>NZ_CP011502.1|WP_067854611.1|672226_673537_+|NADH-quinone-oxidoreductase-subunit-NuoF
MADTLTPVLSRGWADERSWTREAYEARDGYSALRTALDMAPDEIVTLVKDAGLRGRGGAGFPTGMKWSFIPQENPNPKYLVVNADESEPGTCKDIPLMMANPHELIEGVVIASLAIRAEQAFVYVRGEVLHVVRRLRAACREAYEAGYLGADVMGSGRRVDLVIHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVEGLYASPTVINNVESIASVPAIVRGGVEWFGSMGTEKSKGFTLYSLSGHVKRPGQYEAPLGTTLRELLDLGGGLRDGAELKFWTPGGSSTPILTAEHLDVPLDYEGVGAAGSMLGTKALQVFDQTTSVVRCVLRWTEFYKHESCGKCTPCREGTWWLVQVLQRLDAGQGRAGDVELLLDLCDNILGRSFCALGDGATSPITSAVRHFRDEFEAGMHTSSAELFPPAASTLFAAEVSA
>NZ_CP011502.1|WP_067854614.1|673533_676026_+|NADH-quinone-oxidoreductase-subunit-G
MTVEASRETQTPVDLVTLTIDDVEVSVPKGTLVIRAAELVGTEIPRFCDHPLLEPVGACRQCLVEVPDAGNGRGFPKPQASCTLEVAPGMVVRTQVTSPVAEKAQHGTMELLLVNHPLDCPVCDKGGECPLQNQAMSHGRGESRFAETKRTFPKPLAVSEQVLLDRERCVLCARCTRFSEQIAGDPFIALVERGARQQVGIGPSVDAEAFGDRAGADGEGGGEQPFHSYFSGNTIQICPVGALTSADYRFRSRPFDLVSTPSVAEHDACGAAIRVDHRRGAVMRRLAGDDPEVNEEWVTDKDRFAFTWSRQDDRLRTPLVRDPGTGELVPTSWPGALAAAAAGLREAAGKVGVLPGGRLTAEDAYAYSVFARVALGTNDIDFRARPHSAEESAFLAARVATRQDVATRDLESASTVLLVGLEPEDEAGTLFLRLRKASRHGVRVVAVGSHTTRGLAKCGGELLAARPGEEASALDAIQDGDGSAGVGLDPRAVVLLGERLASSPGAFSAAVRLAERTGARLAWVPRRAGDRGAVETGCLPTLLPGGRPVADAEARADLAAAWGVRSVPAQTGRDTTAMLRAVAEGQLRALVVGGVELDDLPDAALAREALAAADFVVSLEVRESDVTRVADVVLPVAPPVEKSGTFVTWEGRLRPFGTVLEVPGSLTDVRVLAGVAEELGAPLGFRTTAGAMRSMRDLGPWDGEPLPAPDVPAREQPALEEPRPGGAVVLATWRQLVDDGRLQDGQDRYRATARRAVLKASAATLAAAGVEVGDVATIATDLGSASFPTEVADLPDGVVWAPGNNGVHLRGTLGADHGSTVRLLPGGEQA
>NZ_CP011502.1|WP_067854617.1|676022_677276_+|NADH-quinone-oxidoreductase-subunit-NuoH
MSEAFGNEAFWVVALKALLVFVILVVYTLFNIWFERRVVARMQHRVGPNVHGRFGLLQSLADGVKLALKEDIVVKAADKVVYVLAPIIATIPAFLAWAVIPFGPEVRIPFTDTVTPLQLTDMPVAVLYVLAVTSIGVYGIVLAGWSSGSTYSLLGGLRSSAQVISYEVAMGLSFVTVFLYAGTMSTSEIVAAQEDVWYFLPLLPSFIIYVIAMVGETNRAPFDLPEAEGELVGGFHTEYSSLKFALFFLAEYINMVTVSAIATTLFLGGWRAPFGIGTLWPGANEGYWPVLWFLGKTLGFIFLFIWLRGTLPRMRYDQFMAFGWKVLIPISLVWIVAVIVVRKGMTDGTFDQRTLFVAAGVAAAVLLVSLLLPERKPSDPEQTAEVDAPAPTDHGGGSYPTPPMPEQTWNQKEGVRR
>NZ_CP011502.1|WP_067854620.1|677272_677863_+|NADH-quinone-oxidoreductase-subunit-NuoI
MSDTNGGGSLKETLWDPIAGFGVTFRTMFRKPVTEQYPFEKRPTAPRFHGRHQLNRWPDGLEKCVGCELCAWACPADAIYVEGASNGTSDGTDGGGERFSPGERYGRVYQINYLRCILCGLCIEACPTRALTMTNEYELADDNRADLIYEKSDLLAPLLPGMVEPPHAMLISDDHHDYYAGKTLPVVEVTHGEATE

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Crispr_ID: NZ_CP011502_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_9

876152-876220

Orphan

Consensus_repeat	Method
ACCGGGTCGGGCGACGTGGAGGC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP011502_9

>merge|NZ_CP011502|9|876152-876220|CRISPRCasFinder
ACCGGCGAGCTCGACCTGGAGGGATCCGGACTCCTGCGGCTGCAGGCCGGGCCGACCGACGTGCGGGTC

>NZ_CP011502|9|9|876152-876220|CRISPRCasFinder
ACCGGCGAGCTCGACCTGGAGGG	ATCCGGACTCCTGCGGCTGCAG
GCCGGGCCGACCGACGTGCGGGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067855080.1\|874241_875978_+\|glycerol-3-phosphate-dehydrogenase/oxidase	unknown	unknown	gnl\|CDD\|223651
NZ_CP011502.1\|WP_067855069.1\|870269_870977_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067855095.1\|879733_880093_-\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|223317
NZ_CP011502.1\|WP_067855092.1\|878886_879684_+\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|372611
NZ_CP011502.1\|WP_158509170.1\|868058_868229_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067855072.1\|871040_871487_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067855106.1\|886470_888153_+\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NZ_CP011502.1\|WP_144433658.1\|881705_882914_+\|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|379143
NZ_CP011502.1\|WP_067855060.1\|867318_867999_+\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_CP011502.1\|WP_067855063.1\|868547_869399_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187572
NZ_CP011502.1\|WP_067861325.1\|883038_884745_+\|dynamin-family-protein	unknown	unknown	gnl\|CDD\|366045
NZ_CP011502.1\|WP_067855100.1\|880517_881468_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381391
NZ_CP011502.1\|WP_067855085.1\|877442_877646_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP011502.1\|WP_067861323.1\|868233_868533_-\|DUF503-domain-containing-protein	unknown	unknown	gnl\|CDD\|377364
NZ_CP011502.1\|WP_067855075.1\|873570_874116_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067855098.1\|880089_880482_-\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|376809
NZ_CP011502.1\|WP_083516246.1\|871862_873524_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NZ_CP011502.1\|WP_067855089.1\|878103_878736_-\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429
NZ_CP011502.1\|WP_083516247.1\|884741_886403_+\|50S-ribosome-binding-GTPase	unknown	unknown	gnl\|CDD\|206743
NZ_CP011502.1\|WP_067855066.1\|869457_869739_-\|zf-TFIIB-domain-containing-protein	unknown	unknown	gnl\|CDD\|226331

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067855080.1\|874241_875978_+\|glycerol-3-phosphate-dehydrogenase/oxidase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	5.49081e-166
NZ_CP011502.1\|WP_144433658.1\|881705_882914_+\|PrsW-family-intramembrane-metalloprotease	gnl\|CDD\|379143	pfam13367, PrsW-protease, Protease prsW family. This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Aflv_1074, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress.	2.44952e-38
NZ_CP011502.1\|WP_067855095.1\|879733_880093_-\|CrcB-family-protein	gnl\|CDD\|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	5.18747e-23
NZ_CP011502.1\|WP_067855092.1\|878886_879684_+\|thioredoxin-domain-containing-protein	gnl\|CDD\|372611	pfam13462, Thioredoxin_4, Thioredoxin.	4.75877e-25
NZ_CP011502.1\|WP_067855106.1\|886470_888153_+\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NZ_CP011502.1\|WP_067855089.1\|878103_878736_-\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	1.13074e-107
NZ_CP011502.1\|WP_067855060.1\|867318_867999_+\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.0458e-72
NZ_CP011502.1\|WP_067855063.1\|868547_869399_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187572	cd05262, SDR_a7, atypical (a) SDRs, subgroup 7. This subgroup contains atypical SDRs of unknown function. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.04375e-53
NZ_CP011502.1\|WP_067861325.1\|883038_884745_+\|dynamin-family-protein	gnl\|CDD\|366045	pfam00350, Dynamin_N, Dynamin family.	3.18314e-09
NZ_CP011502.1\|WP_067855100.1\|880517_881468_+\|aldo/keto-reductase	gnl\|CDD\|381391	cd19752, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	1.01401e-127
NZ_CP011502.1\|WP_067855085.1\|877442_877646_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.82633e-39
NZ_CP011502.1\|WP_067861323.1\|868233_868533_-\|DUF503-domain-containing-protein	gnl\|CDD\|377364	pfam04456, DUF503, Protein of unknown function (DUF503). Family of hypothetical bacterial proteins.	9.46133e-29
NZ_CP011502.1\|WP_083516246.1\|871862_873524_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	5.6948e-51
NZ_CP011502.1\|WP_067855098.1\|880089_880482_-\|CrcB-family-protein	gnl\|CDD\|376809	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB). CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance.	9.4419e-24
NZ_CP011502.1\|WP_083516247.1\|884741_886403_+\|50S-ribosome-binding-GTPase	gnl\|CDD\|206743	cd11383, YfjP, YfjP GTPase. The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.	1.78979e-29
NZ_CP011502.1\|WP_067855066.1\|869457_869739_-\|zf-TFIIB-domain-containing-protein	gnl\|CDD\|226331	COG3809, COG3809, Uncharacterized protein conserved in bacteria [Function unknown].	1.50794e-21

>NZ_CP011502.1|WP_067855080.1|874241_875978_+|glycerol-3-phosphate-dehydrogenase/oxidase
MRPVPLSPHARQAALDAMEAAPLDVLVIGGGVVGAGAALDAATRGLSVGLVEARDFASGTSSRSSKLMHGGLRYLEMLDFRLVAEALKERGLNLQKLAPHLVQEVAFLYPLQHRGWERFYAGSGVALYDAMSKASGYGKGVPLHRHHTRRGARKIFPGLRKDALVGALRYYDAQVDDARHTMFLARTSAAYGAHVASRTRVVDLLREGGRVVGARLKDLESGRELDVRASVVLNATGVWTDETQGMAAERGQFHVRASKGIHLVVPRDRIRGEGGLILRTEKSVLFVIPWGRHWIIGTTDTDWDLSKDHPAASRNDIDYLLEHVNRVLVEPLTHADVEGVYAGLRPLLAGEDEATSKLSREHAVSTSVKGLVVIAGGKYTTYRVMAKDAVDAAVHSMTRQLDRVVPASCTEDVPLLGADGFEALWNQRHRLAADSGLSVARIEHLLRRYGSLVVEVLDLVTTDATLGEPLGGADDYLRAEVVYGTTHEGARHLDDVIARRTRISIETFDRGTEVAREVADLMGDALGWTGEQRDVEVEHYLKRVAAERESQTMPDDETADAARMGAPDVVPVATADTP
>NZ_CP011502.1|WP_067855075.1|873570_874116_-|hypothetical-protein
MAVGILAGLALLAALLVPMGGSGASGRDAAAADDQGVERPGLSRSTPSPSMSAAASDPDAEPKGLAPRSVTGLQEPAGLPGSGGSFSVRARRITLSATSSEPIGVVGYLVPTSRDRPSGTVTGVGTSWSMSTLVYGRPDYAQMFMQAGPSGATITCTITVDGRVTEQRSSAGPYGQLFCQG
>NZ_CP011502.1|WP_083516246.1|871862_873524_-|NAD(P)/FAD-dependent-oxidoreductase
MTRRWFTQPEGSGWYAVPSDEVAESREETADVVVLGGGHNALVAATYLARAGLDVVLLERLDHVGGAAVSARTFPEHDARLSRYSYLVSLMPEALVRELGLDLELRSRGTASYTPYERDGEPRGLLVETDEGEATRVSFRALTGDDDAFEAWRAFYGEVGGLAAAVAPTLLQPLPRVGDLGPATGQPVWTDVVERPLGEALERRFADDVVRGVVGTDGLIGTFASLHDPSLAQNRCFLYHLVGNGTGEWRVPVGGMGAVTGELERVAREAGVRILTGATVTRVKQLEEREACDCGDPGEEAGVVVDAVGDDGPLHVSAAYALSGIAPHALDALLWPDDQAGLPRPSGSQLKINLLVSRLPRLRSGDDPTVAFAGTFHVDEAMSQVEALHAAAERGEQPFASGELYCHTLTDRSILGPELAATDAQTLTWFGLHTPYENLLDDGAAEREYRRFLTAIDAYLAEPLEPLVLGVEVKTPADVEQALAMPGGHIFHGDLAWPWLEDDEPAETPAQRWGVATAHDRILLCGSGARRGGAVSGIAGHNAAHALLELLGR
>NZ_CP011502.1|WP_067855072.1|871040_871487_-|hypothetical-protein
MTQILVALVTFGLPALVAIGSSSRRQLSLIREEVKTLKELPTDSIAAQRMRDQIDEAVRLYMVTSHGKSRFWNRLSLFIGLTLIYWGFAFALLLTADSSIVSDLYRDEREEAFGTVLAIGVTIAGVILIVVTLLQRLTHRRSAEGRRK
>NZ_CP011502.1|WP_067855069.1|870269_870977_-|hypothetical-protein
MDAGSLADWVAAVGTMLALVWALFLYRRNIREREERAARQVYPLDHGSGNVQPDEPAEFAPEVFDIFVHDDVEHGGYLIRSAAHGNPMRSTIVPKQVTLVYTAAIVNGSDEPITTVNFEIATLGGATVKSFTYDRVQIVLPGETKAVVLLLPHFKDRAGSSVLMLGLTVAVRFTDSSGRRWRRVVGWPTESVENEWYNGRRPRTFRRDVGRFRRKAAVRVKKIGRYFWPAKLNQK
>NZ_CP011502.1|WP_067855066.1|869457_869739_-|zf-TFIIB-domain-containing-protein
MKCPTDGSTLTMSERAGVEIDYCPECRGVWLDRGELDKILDRATADAPAAPAPRDERRPERDRDDRYRPDDRYRDDRYRKPKKKEHWLMEILG
>NZ_CP011502.1|WP_067855063.1|868547_869399_-|NAD-dependent-epimerase/dehydratase-family-protein
MKILLTGGTGFVGAAVLRRLVDDGHAVTAVVRSESSGQTVAAAGATPLQGDLFDRAWLAAQLREHDAGVHTAAPGDETSATMDDAVVDAAVEAFAGTDKPFVHTGGVWTYGSGADLDEETPYDAPAITAWRQAREDRLLDSSVRATVVQPGIVHAPGQGIAQQLVAAPRTGEGALELVGSGEQHWTTIHVDDLADLYALVVASGSGHGRLLGVSGHSPSVRDLGLALADAVAGTSVETVHERLGEAFGDALLLDQQASGAKARSLGWQPTRPTLVEELRAARA
>NZ_CP011502.1|WP_067861323.1|868233_868533_-|DUF503-domain-containing-protein
MWVGWLEAELLLGDVHTLKQKRAVVRPVVAELRRALDVSVAEVGHTDLYRRTVVGVALTSGDHAHADALLDRAERLLASRPDVDLLSVRRRLVRSDDLD
>NZ_CP011502.1|WP_158509170.1|868058_868229_+|hypothetical-protein
MTAAPDHRPVPAAPADEPRPPHTLQESLERFGGAWLAAGVTTVVGAVALTARVVVG
>NZ_CP011502.1|WP_067855060.1|867318_867999_+|response-regulator
MTVVLAVDDDAAILRTLGIAMRARGYEVETVADGRSALQSLTERVPDVVLLDLGLPDLDGTEVLRRIRETSQVPVVVLSARHESDDKVEALDLGADDYVTKPFGMEELLARVRAALRRAAPSRAPVVTVGDLVLDVEDRRATRAGEPVHLTPTEWKIVEVLARAQGRLVRQTTLLTEVWGPTYERETHYLRVYLAQLRRKLEDDPAHPRMLITDPGLGYRLLSDLS
>NZ_CP011502.1|WP_067855085.1|877442_877646_-|cold-shock-protein
MATGTVKWFNADKGFGFIAPDQGGEDVFAHFSAIQASGYRSLEENQKVEFDVEQGQKGLQAANIRPL
>NZ_CP011502.1|WP_067855089.1|878103_878736_-|oligoribonuclease
MNDRLVWIDCEMTGLSLETDALVEVAALVTDYELNVLGQGVDLVIKPPAQALEQMNDVVTRMHTASGLITELEAGTTLRDAEEQVLAYVREHVKEPRKAPLAGNTVGTDRTFLARDMVELEGFLHYRVIDVSSIKELARQWFPRAYFAAPAKAGHHRALADIAESIDELRYYRRAVFVGDPGPETEAARALAAEVAASSTLGRLEGSEES
>NZ_CP011502.1|WP_067855092.1|878886_879684_+|thioredoxin-domain-containing-protein
MSNDRKQRAEQMRKEREKADKRQRNVITIAIVAVVIALVGVGGYAVKSTADKNAKSTDLVAPKNTKDYGIVYDQAAAESADGGASDGGAASGDAKPVSVEVYEDFQCPVCQQFEQVAGPMLKQQVASGEIALTYKPFSFLDENGGSTNDYSKRATNAALCALDAGGVDDYVKVHDFLYANQPQEGTAGPENAKLVEDLKSLGITGAGIDSCVKSEKFVPWVVKAKEVAQDSDRKISGTPTVFVDGKKLDDFSPATIQKAVEEAKA
>NZ_CP011502.1|WP_067855095.1|879733_880093_-|CrcB-family-protein
MTGALLAGAVAVAGGAGSVLRLLVDTWVGQRSSGRFPWGIVAVNVTGSFLIGLAVGLLDDGAARTVVATGFLGGYTTFSTASLDSARLALRGRGGRAVAHAVGTAVVCVAAAWLGLLLT
>NZ_CP011502.1|WP_067855098.1|880089_880482_-|CrcB-family-protein
MATTWPRPDAVALVAAGGAVGTLVRYGVAASVDPVDGLPVGILGVNLLGAFLLGVLTATVASSRTRLLLGTGLMGGFTTYSAFALDTQGLLADGRPADALVYLLATVAGGFAASVGGLAVGRALRVRGAR
>NZ_CP011502.1|WP_067855100.1|880517_881468_+|aldo/keto-reductase
MDVSRLVLGTMYLGTRTDEATSRALLDRFLDAGGRTLDTANCYAFWVDPSGHGGASERVIGGWLAAEPSRRDRVELATKVGVEPLDVPRRDGHPVEGLSAEVVRAGCEASLRRLGIDVIDLYWAHGEDRGTPLEETVEAFGSLVAAGAVRRLGVSNHPTWRVERGRALAEARGLEPWTALQLTTSYVHPRPGAAVEGKDHRFGFVTDETVDYVSEHPDVELWAYSPLVRGAYDRPDRPFPQAYRHLGTERRLAVLDDVAQAHGVARSVVVLAWLLASRPEVRPILGVSSVEQLESALRVADVDLAPDELAALDAPA
>NZ_CP011502.1|WP_144433658.1|881705_882914_+|PrsW-family-intramembrane-metalloprotease
MSQPHAQEAAPEVAGRGTIPRRMPRYVERPRQRGRTVLIVLTGIGVALGLVEVVVVAAGAEALEGARLAIIYALVPLPVLWFVYWWLDRYEPEPRRYKVAAFVWGGVGAVGIALAVQVLLGETTDLTQKELATFVAPASEEPAKGLFLLLTFLRWRRIIDGFLDGLIVAGLVGLGFAFVENIGYYALSYAGGPDVPIAGAEGAAGTFVVRGIASPFAHPLFLSAFGIALGLAVGIRSKVLKVLVGTLGLAISMALHGLWNGSASYFGGVGFALTYVALFVLFVTLAVVAIVARSRQVRTLERSLSYVAERGWIHPAEIPYLSRFGYRKQARRHARRHHGRVAGRIVRRYQRLATEMAFLHDAIMRGQTKPHGVERTYALLDAMYGLRPALRFPPPLPVAHRR
>NZ_CP011502.1|WP_067861325.1|883038_884745_+|dynamin-family-protein
MLGALSKLLTDVTAAPLALEVPGVDEVRSTRAEMVDQLSDYVIPRLVQLEAPLLTVVGGSTGAGKSTLVNSLVGEQVTQSGVLRPTTRSPVLVHHPDDAEWFQPDRILPELPRTKAVTNDVYALRLAPSTGVPRGLAILDAPDIDSIDAANRELATQLLAAADLWLFVTSAARYADQVPWDYLGRAAERSTSVAVVLDRTHADAVVEVRGHLARMMTSRGLSDSPLFTVPESAVGEDGLLPREAVEPIRGWLRDLAADPEGRSAVVFGTLDGAVRHNVLRSHVVADGLDEQLAAARQLHDDATRTYAEAVDLLRRATADGTVMRGEVLTRWQEFVGNGELLRSVEERVSRIRDRLVDQVTGKRTRSAEVSEAVESGLQTLLVEQLEAAAEAVYRSWSSVGAGRALIASERGLDRASRDVRVKAERLVRDWQAEVLELVRAEGSDKRLTAKFLAFGVNGIGVALMVLVFVSGSAGLTGAEVGVAGGTAVVAQKLLEAIFGDQAVRRLAERAHTSLVTAVEALATAESRRYLDLVSDPAVIEASQARLRDAARRAEYARHIDFLDGETAS
>NZ_CP011502.1|WP_083516247.1|884741_886403_+|50S-ribosome-binding-GTPase
MSERPGPVARATSALFGGERNDVAARLDGLGEAVEAARGRLDDTLLDPAAALAERASERLRLSGEHTIVALAGATGSGKSSLFNCLTDLELAGVGVRRPTTSWALACSWGPDGAQELLEWMGIPARHQVSRMSMLDRSSADTKLDGLVLLDLPDHDSTEVSHHLEMDRLVQYADLLIWVLDPQKYADAAIHDRYIRPMAAYRDVTLVVLNQIDRIHFSERERALGDVRAILDREGLPGVPVLGVSAHRGDGVDDLKRELARRIRAKASAKERLAQDIAASAAGIVTVGGRSDIPGITDIDRQALDLALLDSVGAPQLVEAVEASTLRTARRHTGWPPLRWVGRLRKDPLRELGIDPDGSIASLSRAVRPSVGHVQRAQAESAVREISEKAAVGLERPWRDAVREASVSTSADVVRELDETVDRIDLGLSRTPFWWRAVDVLQWLAFAALVVGVGWGAVELLSGLVGWEVGDAPVVAGTSLPLLLLLGGLVGGVLLAALSRAAVRTSARRRAQQADATLRRAVAEVSEQKVVAPLQAELDRYERYRSGILRALG
>NZ_CP011502.1|WP_067855106.1|886470_888153_+|energy-dependent-translational-throttle-protein-EttA
MADYVLSLRNVRKAHGDKVVLDDVTLSFLHGAKIGVVGPNGMGKSSLLKLMAGLDQPNNGDIVRDPEATVGMLQQEPPLTEGKTVLENVEEAVSEVKDKMKRLEEAYAEMGEPDADYDALMAETGDLQTFLDSVNAWDLDSRLDQAMDALRCPPPDELVDHLSGGERRRVALCKLLLQQPDLLLLDEPTNHLDAESVQWLEGHLKTYPGAVLAVTHDRYFLDNVAEWIAEVDRGRIHGYEGNYSTYLETKKERLKIEGAKDAKRAKMLEKELDWVRSNAKGRQAKSKARLARYEELAAEAERARKIDTSEINIPAGPRLGDVVLDAKSLSKGFEGRTLWDDISFSLPRAGIVGVVGPNGVGKTTLFRMITGNEVPDAGTLEVGQTVKISYADQSRGSIAADKNVWEVVSDGLDFIKVANFEMNSRAYVASFGFKGADQQKKAGVLSGGERNRLNLALTLKQGGNLLLLDEPTNDLDVETLSSLEDALLDFPGCAVVTSHDRWFLDRIATHILAWEGTEDEPGRWFWFEGNFASYEENKIERLGEEAARPHRVTHRRLTRD

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Crispr_ID: NZ_CP011502_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_10

876410-876544

Orphan

Consensus_repeat	Method
ACCGGGTCGGGCGACGTGGAGGC	CRISPRCasFinder

2 spacers

DEDDh

The CRISPR arrays of NZ_CP011502_10

>merge|NZ_CP011502|10|876410-876544|CRISPRCasFinder
ACCGGGTCCGGCGACGTCGACGTCTCGGGACTCGACGGGGCGGTGGCCGTGCGGACCGGGTCGGGCGACGTGGAGGCCGAGCGGCTGCGCACGCAGGACCTCACCGTCCGCACCGGGTCGGGCGACGTCGAGGCG

>NZ_CP011502|10|10|876410-876544|CRISPRCasFinder
ACCGGGTCCGGCGACGTCGACGT	CTCGGGACTCGACGGGGCGGTGGCCGTGCGG
ACCGGGTCGGGCGACGTGGAGGC	CGAGCGGCTGCGCACGCAGGACCTCACCGTCCGC
ACCGGGTCGGGCGACGTCGAGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067855080.1\|874241_875978_+\|glycerol-3-phosphate-dehydrogenase/oxidase	unknown	unknown	gnl\|CDD\|223651
NZ_CP011502.1\|WP_067855069.1\|870269_870977_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067855095.1\|879733_880093_-\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|223317
NZ_CP011502.1\|WP_067855092.1\|878886_879684_+\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|372611
NZ_CP011502.1\|WP_158509170.1\|868058_868229_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067855072.1\|871040_871487_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067855106.1\|886470_888153_+\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NZ_CP011502.1\|WP_144433658.1\|881705_882914_+\|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|379143
NZ_CP011502.1\|WP_067855060.1\|867318_867999_+\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_CP011502.1\|WP_067855063.1\|868547_869399_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187572
NZ_CP011502.1\|WP_067861325.1\|883038_884745_+\|dynamin-family-protein	unknown	unknown	gnl\|CDD\|366045
NZ_CP011502.1\|WP_067855100.1\|880517_881468_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381391
NZ_CP011502.1\|WP_067855085.1\|877442_877646_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP011502.1\|WP_067861323.1\|868233_868533_-\|DUF503-domain-containing-protein	unknown	unknown	gnl\|CDD\|377364
NZ_CP011502.1\|WP_067855075.1\|873570_874116_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067855098.1\|880089_880482_-\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|376809
NZ_CP011502.1\|WP_083516246.1\|871862_873524_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NZ_CP011502.1\|WP_067855089.1\|878103_878736_-\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429
NZ_CP011502.1\|WP_083516247.1\|884741_886403_+\|50S-ribosome-binding-GTPase	unknown	unknown	gnl\|CDD\|206743
NZ_CP011502.1\|WP_067855066.1\|869457_869739_-\|zf-TFIIB-domain-containing-protein	unknown	unknown	gnl\|CDD\|226331

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067855080.1\|874241_875978_+\|glycerol-3-phosphate-dehydrogenase/oxidase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	5.49081e-166
NZ_CP011502.1\|WP_144433658.1\|881705_882914_+\|PrsW-family-intramembrane-metalloprotease	gnl\|CDD\|379143	pfam13367, PrsW-protease, Protease prsW family. This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Aflv_1074, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress.	2.44952e-38
NZ_CP011502.1\|WP_067855095.1\|879733_880093_-\|CrcB-family-protein	gnl\|CDD\|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	5.18747e-23
NZ_CP011502.1\|WP_067855092.1\|878886_879684_+\|thioredoxin-domain-containing-protein	gnl\|CDD\|372611	pfam13462, Thioredoxin_4, Thioredoxin.	4.75877e-25
NZ_CP011502.1\|WP_067855106.1\|886470_888153_+\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NZ_CP011502.1\|WP_067855089.1\|878103_878736_-\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	1.13074e-107
NZ_CP011502.1\|WP_067855060.1\|867318_867999_+\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.0458e-72
NZ_CP011502.1\|WP_067855063.1\|868547_869399_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187572	cd05262, SDR_a7, atypical (a) SDRs, subgroup 7. This subgroup contains atypical SDRs of unknown function. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.04375e-53
NZ_CP011502.1\|WP_067861325.1\|883038_884745_+\|dynamin-family-protein	gnl\|CDD\|366045	pfam00350, Dynamin_N, Dynamin family.	3.18314e-09
NZ_CP011502.1\|WP_067855100.1\|880517_881468_+\|aldo/keto-reductase	gnl\|CDD\|381391	cd19752, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	1.01401e-127
NZ_CP011502.1\|WP_067855085.1\|877442_877646_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.82633e-39
NZ_CP011502.1\|WP_067861323.1\|868233_868533_-\|DUF503-domain-containing-protein	gnl\|CDD\|377364	pfam04456, DUF503, Protein of unknown function (DUF503). Family of hypothetical bacterial proteins.	9.46133e-29
NZ_CP011502.1\|WP_083516246.1\|871862_873524_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	5.6948e-51
NZ_CP011502.1\|WP_067855098.1\|880089_880482_-\|CrcB-family-protein	gnl\|CDD\|376809	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB). CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance.	9.4419e-24
NZ_CP011502.1\|WP_083516247.1\|884741_886403_+\|50S-ribosome-binding-GTPase	gnl\|CDD\|206743	cd11383, YfjP, YfjP GTPase. The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.	1.78979e-29
NZ_CP011502.1\|WP_067855066.1\|869457_869739_-\|zf-TFIIB-domain-containing-protein	gnl\|CDD\|226331	COG3809, COG3809, Uncharacterized protein conserved in bacteria [Function unknown].	1.50794e-21

>NZ_CP011502.1|WP_067855080.1|874241_875978_+|glycerol-3-phosphate-dehydrogenase/oxidase
MRPVPLSPHARQAALDAMEAAPLDVLVIGGGVVGAGAALDAATRGLSVGLVEARDFASGTSSRSSKLMHGGLRYLEMLDFRLVAEALKERGLNLQKLAPHLVQEVAFLYPLQHRGWERFYAGSGVALYDAMSKASGYGKGVPLHRHHTRRGARKIFPGLRKDALVGALRYYDAQVDDARHTMFLARTSAAYGAHVASRTRVVDLLREGGRVVGARLKDLESGRELDVRASVVLNATGVWTDETQGMAAERGQFHVRASKGIHLVVPRDRIRGEGGLILRTEKSVLFVIPWGRHWIIGTTDTDWDLSKDHPAASRNDIDYLLEHVNRVLVEPLTHADVEGVYAGLRPLLAGEDEATSKLSREHAVSTSVKGLVVIAGGKYTTYRVMAKDAVDAAVHSMTRQLDRVVPASCTEDVPLLGADGFEALWNQRHRLAADSGLSVARIEHLLRRYGSLVVEVLDLVTTDATLGEPLGGADDYLRAEVVYGTTHEGARHLDDVIARRTRISIETFDRGTEVAREVADLMGDALGWTGEQRDVEVEHYLKRVAAERESQTMPDDETADAARMGAPDVVPVATADTP
>NZ_CP011502.1|WP_067855075.1|873570_874116_-|hypothetical-protein
MAVGILAGLALLAALLVPMGGSGASGRDAAAADDQGVERPGLSRSTPSPSMSAAASDPDAEPKGLAPRSVTGLQEPAGLPGSGGSFSVRARRITLSATSSEPIGVVGYLVPTSRDRPSGTVTGVGTSWSMSTLVYGRPDYAQMFMQAGPSGATITCTITVDGRVTEQRSSAGPYGQLFCQG
>NZ_CP011502.1|WP_083516246.1|871862_873524_-|NAD(P)/FAD-dependent-oxidoreductase
MTRRWFTQPEGSGWYAVPSDEVAESREETADVVVLGGGHNALVAATYLARAGLDVVLLERLDHVGGAAVSARTFPEHDARLSRYSYLVSLMPEALVRELGLDLELRSRGTASYTPYERDGEPRGLLVETDEGEATRVSFRALTGDDDAFEAWRAFYGEVGGLAAAVAPTLLQPLPRVGDLGPATGQPVWTDVVERPLGEALERRFADDVVRGVVGTDGLIGTFASLHDPSLAQNRCFLYHLVGNGTGEWRVPVGGMGAVTGELERVAREAGVRILTGATVTRVKQLEEREACDCGDPGEEAGVVVDAVGDDGPLHVSAAYALSGIAPHALDALLWPDDQAGLPRPSGSQLKINLLVSRLPRLRSGDDPTVAFAGTFHVDEAMSQVEALHAAAERGEQPFASGELYCHTLTDRSILGPELAATDAQTLTWFGLHTPYENLLDDGAAEREYRRFLTAIDAYLAEPLEPLVLGVEVKTPADVEQALAMPGGHIFHGDLAWPWLEDDEPAETPAQRWGVATAHDRILLCGSGARRGGAVSGIAGHNAAHALLELLGR
>NZ_CP011502.1|WP_067855072.1|871040_871487_-|hypothetical-protein
MTQILVALVTFGLPALVAIGSSSRRQLSLIREEVKTLKELPTDSIAAQRMRDQIDEAVRLYMVTSHGKSRFWNRLSLFIGLTLIYWGFAFALLLTADSSIVSDLYRDEREEAFGTVLAIGVTIAGVILIVVTLLQRLTHRRSAEGRRK
>NZ_CP011502.1|WP_067855069.1|870269_870977_-|hypothetical-protein
MDAGSLADWVAAVGTMLALVWALFLYRRNIREREERAARQVYPLDHGSGNVQPDEPAEFAPEVFDIFVHDDVEHGGYLIRSAAHGNPMRSTIVPKQVTLVYTAAIVNGSDEPITTVNFEIATLGGATVKSFTYDRVQIVLPGETKAVVLLLPHFKDRAGSSVLMLGLTVAVRFTDSSGRRWRRVVGWPTESVENEWYNGRRPRTFRRDVGRFRRKAAVRVKKIGRYFWPAKLNQK
>NZ_CP011502.1|WP_067855066.1|869457_869739_-|zf-TFIIB-domain-containing-protein
MKCPTDGSTLTMSERAGVEIDYCPECRGVWLDRGELDKILDRATADAPAAPAPRDERRPERDRDDRYRPDDRYRDDRYRKPKKKEHWLMEILG
>NZ_CP011502.1|WP_067855063.1|868547_869399_-|NAD-dependent-epimerase/dehydratase-family-protein
MKILLTGGTGFVGAAVLRRLVDDGHAVTAVVRSESSGQTVAAAGATPLQGDLFDRAWLAAQLREHDAGVHTAAPGDETSATMDDAVVDAAVEAFAGTDKPFVHTGGVWTYGSGADLDEETPYDAPAITAWRQAREDRLLDSSVRATVVQPGIVHAPGQGIAQQLVAAPRTGEGALELVGSGEQHWTTIHVDDLADLYALVVASGSGHGRLLGVSGHSPSVRDLGLALADAVAGTSVETVHERLGEAFGDALLLDQQASGAKARSLGWQPTRPTLVEELRAARA
>NZ_CP011502.1|WP_067861323.1|868233_868533_-|DUF503-domain-containing-protein
MWVGWLEAELLLGDVHTLKQKRAVVRPVVAELRRALDVSVAEVGHTDLYRRTVVGVALTSGDHAHADALLDRAERLLASRPDVDLLSVRRRLVRSDDLD
>NZ_CP011502.1|WP_158509170.1|868058_868229_+|hypothetical-protein
MTAAPDHRPVPAAPADEPRPPHTLQESLERFGGAWLAAGVTTVVGAVALTARVVVG
>NZ_CP011502.1|WP_067855060.1|867318_867999_+|response-regulator
MTVVLAVDDDAAILRTLGIAMRARGYEVETVADGRSALQSLTERVPDVVLLDLGLPDLDGTEVLRRIRETSQVPVVVLSARHESDDKVEALDLGADDYVTKPFGMEELLARVRAALRRAAPSRAPVVTVGDLVLDVEDRRATRAGEPVHLTPTEWKIVEVLARAQGRLVRQTTLLTEVWGPTYERETHYLRVYLAQLRRKLEDDPAHPRMLITDPGLGYRLLSDLS
>NZ_CP011502.1|WP_067855085.1|877442_877646_-|cold-shock-protein
MATGTVKWFNADKGFGFIAPDQGGEDVFAHFSAIQASGYRSLEENQKVEFDVEQGQKGLQAANIRPL
>NZ_CP011502.1|WP_067855089.1|878103_878736_-|oligoribonuclease
MNDRLVWIDCEMTGLSLETDALVEVAALVTDYELNVLGQGVDLVIKPPAQALEQMNDVVTRMHTASGLITELEAGTTLRDAEEQVLAYVREHVKEPRKAPLAGNTVGTDRTFLARDMVELEGFLHYRVIDVSSIKELARQWFPRAYFAAPAKAGHHRALADIAESIDELRYYRRAVFVGDPGPETEAARALAAEVAASSTLGRLEGSEES
>NZ_CP011502.1|WP_067855092.1|878886_879684_+|thioredoxin-domain-containing-protein
MSNDRKQRAEQMRKEREKADKRQRNVITIAIVAVVIALVGVGGYAVKSTADKNAKSTDLVAPKNTKDYGIVYDQAAAESADGGASDGGAASGDAKPVSVEVYEDFQCPVCQQFEQVAGPMLKQQVASGEIALTYKPFSFLDENGGSTNDYSKRATNAALCALDAGGVDDYVKVHDFLYANQPQEGTAGPENAKLVEDLKSLGITGAGIDSCVKSEKFVPWVVKAKEVAQDSDRKISGTPTVFVDGKKLDDFSPATIQKAVEEAKA
>NZ_CP011502.1|WP_067855095.1|879733_880093_-|CrcB-family-protein
MTGALLAGAVAVAGGAGSVLRLLVDTWVGQRSSGRFPWGIVAVNVTGSFLIGLAVGLLDDGAARTVVATGFLGGYTTFSTASLDSARLALRGRGGRAVAHAVGTAVVCVAAAWLGLLLT
>NZ_CP011502.1|WP_067855098.1|880089_880482_-|CrcB-family-protein
MATTWPRPDAVALVAAGGAVGTLVRYGVAASVDPVDGLPVGILGVNLLGAFLLGVLTATVASSRTRLLLGTGLMGGFTTYSAFALDTQGLLADGRPADALVYLLATVAGGFAASVGGLAVGRALRVRGAR
>NZ_CP011502.1|WP_067855100.1|880517_881468_+|aldo/keto-reductase
MDVSRLVLGTMYLGTRTDEATSRALLDRFLDAGGRTLDTANCYAFWVDPSGHGGASERVIGGWLAAEPSRRDRVELATKVGVEPLDVPRRDGHPVEGLSAEVVRAGCEASLRRLGIDVIDLYWAHGEDRGTPLEETVEAFGSLVAAGAVRRLGVSNHPTWRVERGRALAEARGLEPWTALQLTTSYVHPRPGAAVEGKDHRFGFVTDETVDYVSEHPDVELWAYSPLVRGAYDRPDRPFPQAYRHLGTERRLAVLDDVAQAHGVARSVVVLAWLLASRPEVRPILGVSSVEQLESALRVADVDLAPDELAALDAPA
>NZ_CP011502.1|WP_144433658.1|881705_882914_+|PrsW-family-intramembrane-metalloprotease
MSQPHAQEAAPEVAGRGTIPRRMPRYVERPRQRGRTVLIVLTGIGVALGLVEVVVVAAGAEALEGARLAIIYALVPLPVLWFVYWWLDRYEPEPRRYKVAAFVWGGVGAVGIALAVQVLLGETTDLTQKELATFVAPASEEPAKGLFLLLTFLRWRRIIDGFLDGLIVAGLVGLGFAFVENIGYYALSYAGGPDVPIAGAEGAAGTFVVRGIASPFAHPLFLSAFGIALGLAVGIRSKVLKVLVGTLGLAISMALHGLWNGSASYFGGVGFALTYVALFVLFVTLAVVAIVARSRQVRTLERSLSYVAERGWIHPAEIPYLSRFGYRKQARRHARRHHGRVAGRIVRRYQRLATEMAFLHDAIMRGQTKPHGVERTYALLDAMYGLRPALRFPPPLPVAHRR
>NZ_CP011502.1|WP_067861325.1|883038_884745_+|dynamin-family-protein
MLGALSKLLTDVTAAPLALEVPGVDEVRSTRAEMVDQLSDYVIPRLVQLEAPLLTVVGGSTGAGKSTLVNSLVGEQVTQSGVLRPTTRSPVLVHHPDDAEWFQPDRILPELPRTKAVTNDVYALRLAPSTGVPRGLAILDAPDIDSIDAANRELATQLLAAADLWLFVTSAARYADQVPWDYLGRAAERSTSVAVVLDRTHADAVVEVRGHLARMMTSRGLSDSPLFTVPESAVGEDGLLPREAVEPIRGWLRDLAADPEGRSAVVFGTLDGAVRHNVLRSHVVADGLDEQLAAARQLHDDATRTYAEAVDLLRRATADGTVMRGEVLTRWQEFVGNGELLRSVEERVSRIRDRLVDQVTGKRTRSAEVSEAVESGLQTLLVEQLEAAAEAVYRSWSSVGAGRALIASERGLDRASRDVRVKAERLVRDWQAEVLELVRAEGSDKRLTAKFLAFGVNGIGVALMVLVFVSGSAGLTGAEVGVAGGTAVVAQKLLEAIFGDQAVRRLAERAHTSLVTAVEALATAESRRYLDLVSDPAVIEASQARLRDAARRAEYARHIDFLDGETAS
>NZ_CP011502.1|WP_083516247.1|884741_886403_+|50S-ribosome-binding-GTPase
MSERPGPVARATSALFGGERNDVAARLDGLGEAVEAARGRLDDTLLDPAAALAERASERLRLSGEHTIVALAGATGSGKSSLFNCLTDLELAGVGVRRPTTSWALACSWGPDGAQELLEWMGIPARHQVSRMSMLDRSSADTKLDGLVLLDLPDHDSTEVSHHLEMDRLVQYADLLIWVLDPQKYADAAIHDRYIRPMAAYRDVTLVVLNQIDRIHFSERERALGDVRAILDREGLPGVPVLGVSAHRGDGVDDLKRELARRIRAKASAKERLAQDIAASAAGIVTVGGRSDIPGITDIDRQALDLALLDSVGAPQLVEAVEASTLRTARRHTGWPPLRWVGRLRKDPLRELGIDPDGSIASLSRAVRPSVGHVQRAQAESAVREISEKAAVGLERPWRDAVREASVSTSADVVRELDETVDRIDLGLSRTPFWWRAVDVLQWLAFAALVVGVGWGAVELLSGLVGWEVGDAPVVAGTSLPLLLLLGGLVGGVLLAALSRAAVRTSARRRAQQADATLRRAVAEVSEQKVVAPLQAELDRYERYRSGILRALG
>NZ_CP011502.1|WP_067855106.1|886470_888153_+|energy-dependent-translational-throttle-protein-EttA
MADYVLSLRNVRKAHGDKVVLDDVTLSFLHGAKIGVVGPNGMGKSSLLKLMAGLDQPNNGDIVRDPEATVGMLQQEPPLTEGKTVLENVEEAVSEVKDKMKRLEEAYAEMGEPDADYDALMAETGDLQTFLDSVNAWDLDSRLDQAMDALRCPPPDELVDHLSGGERRRVALCKLLLQQPDLLLLDEPTNHLDAESVQWLEGHLKTYPGAVLAVTHDRYFLDNVAEWIAEVDRGRIHGYEGNYSTYLETKKERLKIEGAKDAKRAKMLEKELDWVRSNAKGRQAKSKARLARYEELAAEAERARKIDTSEINIPAGPRLGDVVLDAKSLSKGFEGRTLWDDISFSLPRAGIVGVVGPNGVGKTTLFRMITGNEVPDAGTLEVGQTVKISYADQSRGSIAADKNVWEVVSDGLDFIKVANFEMNSRAYVASFGFKGADQQKKAGVLSGGERNRLNLALTLKQGGNLLLLDEPTNDLDVETLSSLEDALLDFPGCAVVTSHDRWFLDRIATHILAWEGTEDEPGRWFWFEGNFASYEENKIERLGEEAARPHRVTHRRLTRD

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Crispr_ID: NZ_CP011502_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_11

876647-876741

Orphan

Consensus_repeat	Method
ACCGGGTCGGGCGACGTGGAGGC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP011502_11

>merge|NZ_CP011502|11|876647-876741|CRISPRCasFinder
AGCGAGTCCGGCGAGGTCGACGACACCATCCCCGCCACCGACGCGCAGGACGCCCGCGTCGTACGCGTCAGGACGCAGTCCGGCGACGTCGAGGT

>NZ_CP011502|11|11|876647-876741|CRISPRCasFinder
AGCGAGTCCGGCGAGGTCGACGA	CACCATCCCCGCCACCGACGCGCAGGACGCCCGCGTCGTACGCGTCAGG
ACGCAGTCCGGCGACGTCGAGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067855080.1\|874241_875978_+\|glycerol-3-phosphate-dehydrogenase/oxidase	unknown	unknown	gnl\|CDD\|223651
NZ_CP011502.1\|WP_067855069.1\|870269_870977_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067855095.1\|879733_880093_-\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|223317
NZ_CP011502.1\|WP_067855092.1\|878886_879684_+\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|372611
NZ_CP011502.1\|WP_158509170.1\|868058_868229_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067855072.1\|871040_871487_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067855106.1\|886470_888153_+\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NZ_CP011502.1\|WP_144433658.1\|881705_882914_+\|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|379143
NZ_CP011502.1\|WP_067855060.1\|867318_867999_+\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_CP011502.1\|WP_067855063.1\|868547_869399_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187572
NZ_CP011502.1\|WP_067861325.1\|883038_884745_+\|dynamin-family-protein	unknown	unknown	gnl\|CDD\|366045
NZ_CP011502.1\|WP_067855100.1\|880517_881468_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381391
NZ_CP011502.1\|WP_067855085.1\|877442_877646_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP011502.1\|WP_067861323.1\|868233_868533_-\|DUF503-domain-containing-protein	unknown	unknown	gnl\|CDD\|377364
NZ_CP011502.1\|WP_067855075.1\|873570_874116_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067855098.1\|880089_880482_-\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|376809
NZ_CP011502.1\|WP_083516246.1\|871862_873524_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NZ_CP011502.1\|WP_067855089.1\|878103_878736_-\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429
NZ_CP011502.1\|WP_083516247.1\|884741_886403_+\|50S-ribosome-binding-GTPase	unknown	unknown	gnl\|CDD\|206743
NZ_CP011502.1\|WP_067855066.1\|869457_869739_-\|zf-TFIIB-domain-containing-protein	unknown	unknown	gnl\|CDD\|226331

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067855080.1\|874241_875978_+\|glycerol-3-phosphate-dehydrogenase/oxidase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	5.49081e-166
NZ_CP011502.1\|WP_144433658.1\|881705_882914_+\|PrsW-family-intramembrane-metalloprotease	gnl\|CDD\|379143	pfam13367, PrsW-protease, Protease prsW family. This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Aflv_1074, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress.	2.44952e-38
NZ_CP011502.1\|WP_067855095.1\|879733_880093_-\|CrcB-family-protein	gnl\|CDD\|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	5.18747e-23
NZ_CP011502.1\|WP_067855092.1\|878886_879684_+\|thioredoxin-domain-containing-protein	gnl\|CDD\|372611	pfam13462, Thioredoxin_4, Thioredoxin.	4.75877e-25
NZ_CP011502.1\|WP_067855106.1\|886470_888153_+\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NZ_CP011502.1\|WP_067855089.1\|878103_878736_-\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	1.13074e-107
NZ_CP011502.1\|WP_067855060.1\|867318_867999_+\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.0458e-72
NZ_CP011502.1\|WP_067855063.1\|868547_869399_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187572	cd05262, SDR_a7, atypical (a) SDRs, subgroup 7. This subgroup contains atypical SDRs of unknown function. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.04375e-53
NZ_CP011502.1\|WP_067861325.1\|883038_884745_+\|dynamin-family-protein	gnl\|CDD\|366045	pfam00350, Dynamin_N, Dynamin family.	3.18314e-09
NZ_CP011502.1\|WP_067855100.1\|880517_881468_+\|aldo/keto-reductase	gnl\|CDD\|381391	cd19752, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	1.01401e-127
NZ_CP011502.1\|WP_067855085.1\|877442_877646_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.82633e-39
NZ_CP011502.1\|WP_067861323.1\|868233_868533_-\|DUF503-domain-containing-protein	gnl\|CDD\|377364	pfam04456, DUF503, Protein of unknown function (DUF503). Family of hypothetical bacterial proteins.	9.46133e-29
NZ_CP011502.1\|WP_083516246.1\|871862_873524_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	5.6948e-51
NZ_CP011502.1\|WP_067855098.1\|880089_880482_-\|CrcB-family-protein	gnl\|CDD\|376809	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB). CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance.	9.4419e-24
NZ_CP011502.1\|WP_083516247.1\|884741_886403_+\|50S-ribosome-binding-GTPase	gnl\|CDD\|206743	cd11383, YfjP, YfjP GTPase. The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.	1.78979e-29
NZ_CP011502.1\|WP_067855066.1\|869457_869739_-\|zf-TFIIB-domain-containing-protein	gnl\|CDD\|226331	COG3809, COG3809, Uncharacterized protein conserved in bacteria [Function unknown].	1.50794e-21

>NZ_CP011502.1|WP_067855080.1|874241_875978_+|glycerol-3-phosphate-dehydrogenase/oxidase
MRPVPLSPHARQAALDAMEAAPLDVLVIGGGVVGAGAALDAATRGLSVGLVEARDFASGTSSRSSKLMHGGLRYLEMLDFRLVAEALKERGLNLQKLAPHLVQEVAFLYPLQHRGWERFYAGSGVALYDAMSKASGYGKGVPLHRHHTRRGARKIFPGLRKDALVGALRYYDAQVDDARHTMFLARTSAAYGAHVASRTRVVDLLREGGRVVGARLKDLESGRELDVRASVVLNATGVWTDETQGMAAERGQFHVRASKGIHLVVPRDRIRGEGGLILRTEKSVLFVIPWGRHWIIGTTDTDWDLSKDHPAASRNDIDYLLEHVNRVLVEPLTHADVEGVYAGLRPLLAGEDEATSKLSREHAVSTSVKGLVVIAGGKYTTYRVMAKDAVDAAVHSMTRQLDRVVPASCTEDVPLLGADGFEALWNQRHRLAADSGLSVARIEHLLRRYGSLVVEVLDLVTTDATLGEPLGGADDYLRAEVVYGTTHEGARHLDDVIARRTRISIETFDRGTEVAREVADLMGDALGWTGEQRDVEVEHYLKRVAAERESQTMPDDETADAARMGAPDVVPVATADTP
>NZ_CP011502.1|WP_067855075.1|873570_874116_-|hypothetical-protein
MAVGILAGLALLAALLVPMGGSGASGRDAAAADDQGVERPGLSRSTPSPSMSAAASDPDAEPKGLAPRSVTGLQEPAGLPGSGGSFSVRARRITLSATSSEPIGVVGYLVPTSRDRPSGTVTGVGTSWSMSTLVYGRPDYAQMFMQAGPSGATITCTITVDGRVTEQRSSAGPYGQLFCQG
>NZ_CP011502.1|WP_083516246.1|871862_873524_-|NAD(P)/FAD-dependent-oxidoreductase
MTRRWFTQPEGSGWYAVPSDEVAESREETADVVVLGGGHNALVAATYLARAGLDVVLLERLDHVGGAAVSARTFPEHDARLSRYSYLVSLMPEALVRELGLDLELRSRGTASYTPYERDGEPRGLLVETDEGEATRVSFRALTGDDDAFEAWRAFYGEVGGLAAAVAPTLLQPLPRVGDLGPATGQPVWTDVVERPLGEALERRFADDVVRGVVGTDGLIGTFASLHDPSLAQNRCFLYHLVGNGTGEWRVPVGGMGAVTGELERVAREAGVRILTGATVTRVKQLEEREACDCGDPGEEAGVVVDAVGDDGPLHVSAAYALSGIAPHALDALLWPDDQAGLPRPSGSQLKINLLVSRLPRLRSGDDPTVAFAGTFHVDEAMSQVEALHAAAERGEQPFASGELYCHTLTDRSILGPELAATDAQTLTWFGLHTPYENLLDDGAAEREYRRFLTAIDAYLAEPLEPLVLGVEVKTPADVEQALAMPGGHIFHGDLAWPWLEDDEPAETPAQRWGVATAHDRILLCGSGARRGGAVSGIAGHNAAHALLELLGR
>NZ_CP011502.1|WP_067855072.1|871040_871487_-|hypothetical-protein
MTQILVALVTFGLPALVAIGSSSRRQLSLIREEVKTLKELPTDSIAAQRMRDQIDEAVRLYMVTSHGKSRFWNRLSLFIGLTLIYWGFAFALLLTADSSIVSDLYRDEREEAFGTVLAIGVTIAGVILIVVTLLQRLTHRRSAEGRRK
>NZ_CP011502.1|WP_067855069.1|870269_870977_-|hypothetical-protein
MDAGSLADWVAAVGTMLALVWALFLYRRNIREREERAARQVYPLDHGSGNVQPDEPAEFAPEVFDIFVHDDVEHGGYLIRSAAHGNPMRSTIVPKQVTLVYTAAIVNGSDEPITTVNFEIATLGGATVKSFTYDRVQIVLPGETKAVVLLLPHFKDRAGSSVLMLGLTVAVRFTDSSGRRWRRVVGWPTESVENEWYNGRRPRTFRRDVGRFRRKAAVRVKKIGRYFWPAKLNQK
>NZ_CP011502.1|WP_067855066.1|869457_869739_-|zf-TFIIB-domain-containing-protein
MKCPTDGSTLTMSERAGVEIDYCPECRGVWLDRGELDKILDRATADAPAAPAPRDERRPERDRDDRYRPDDRYRDDRYRKPKKKEHWLMEILG
>NZ_CP011502.1|WP_067855063.1|868547_869399_-|NAD-dependent-epimerase/dehydratase-family-protein
MKILLTGGTGFVGAAVLRRLVDDGHAVTAVVRSESSGQTVAAAGATPLQGDLFDRAWLAAQLREHDAGVHTAAPGDETSATMDDAVVDAAVEAFAGTDKPFVHTGGVWTYGSGADLDEETPYDAPAITAWRQAREDRLLDSSVRATVVQPGIVHAPGQGIAQQLVAAPRTGEGALELVGSGEQHWTTIHVDDLADLYALVVASGSGHGRLLGVSGHSPSVRDLGLALADAVAGTSVETVHERLGEAFGDALLLDQQASGAKARSLGWQPTRPTLVEELRAARA
>NZ_CP011502.1|WP_067861323.1|868233_868533_-|DUF503-domain-containing-protein
MWVGWLEAELLLGDVHTLKQKRAVVRPVVAELRRALDVSVAEVGHTDLYRRTVVGVALTSGDHAHADALLDRAERLLASRPDVDLLSVRRRLVRSDDLD
>NZ_CP011502.1|WP_158509170.1|868058_868229_+|hypothetical-protein
MTAAPDHRPVPAAPADEPRPPHTLQESLERFGGAWLAAGVTTVVGAVALTARVVVG
>NZ_CP011502.1|WP_067855060.1|867318_867999_+|response-regulator
MTVVLAVDDDAAILRTLGIAMRARGYEVETVADGRSALQSLTERVPDVVLLDLGLPDLDGTEVLRRIRETSQVPVVVLSARHESDDKVEALDLGADDYVTKPFGMEELLARVRAALRRAAPSRAPVVTVGDLVLDVEDRRATRAGEPVHLTPTEWKIVEVLARAQGRLVRQTTLLTEVWGPTYERETHYLRVYLAQLRRKLEDDPAHPRMLITDPGLGYRLLSDLS
>NZ_CP011502.1|WP_067855085.1|877442_877646_-|cold-shock-protein
MATGTVKWFNADKGFGFIAPDQGGEDVFAHFSAIQASGYRSLEENQKVEFDVEQGQKGLQAANIRPL
>NZ_CP011502.1|WP_067855089.1|878103_878736_-|oligoribonuclease
MNDRLVWIDCEMTGLSLETDALVEVAALVTDYELNVLGQGVDLVIKPPAQALEQMNDVVTRMHTASGLITELEAGTTLRDAEEQVLAYVREHVKEPRKAPLAGNTVGTDRTFLARDMVELEGFLHYRVIDVSSIKELARQWFPRAYFAAPAKAGHHRALADIAESIDELRYYRRAVFVGDPGPETEAARALAAEVAASSTLGRLEGSEES
>NZ_CP011502.1|WP_067855092.1|878886_879684_+|thioredoxin-domain-containing-protein
MSNDRKQRAEQMRKEREKADKRQRNVITIAIVAVVIALVGVGGYAVKSTADKNAKSTDLVAPKNTKDYGIVYDQAAAESADGGASDGGAASGDAKPVSVEVYEDFQCPVCQQFEQVAGPMLKQQVASGEIALTYKPFSFLDENGGSTNDYSKRATNAALCALDAGGVDDYVKVHDFLYANQPQEGTAGPENAKLVEDLKSLGITGAGIDSCVKSEKFVPWVVKAKEVAQDSDRKISGTPTVFVDGKKLDDFSPATIQKAVEEAKA
>NZ_CP011502.1|WP_067855095.1|879733_880093_-|CrcB-family-protein
MTGALLAGAVAVAGGAGSVLRLLVDTWVGQRSSGRFPWGIVAVNVTGSFLIGLAVGLLDDGAARTVVATGFLGGYTTFSTASLDSARLALRGRGGRAVAHAVGTAVVCVAAAWLGLLLT
>NZ_CP011502.1|WP_067855098.1|880089_880482_-|CrcB-family-protein
MATTWPRPDAVALVAAGGAVGTLVRYGVAASVDPVDGLPVGILGVNLLGAFLLGVLTATVASSRTRLLLGTGLMGGFTTYSAFALDTQGLLADGRPADALVYLLATVAGGFAASVGGLAVGRALRVRGAR
>NZ_CP011502.1|WP_067855100.1|880517_881468_+|aldo/keto-reductase
MDVSRLVLGTMYLGTRTDEATSRALLDRFLDAGGRTLDTANCYAFWVDPSGHGGASERVIGGWLAAEPSRRDRVELATKVGVEPLDVPRRDGHPVEGLSAEVVRAGCEASLRRLGIDVIDLYWAHGEDRGTPLEETVEAFGSLVAAGAVRRLGVSNHPTWRVERGRALAEARGLEPWTALQLTTSYVHPRPGAAVEGKDHRFGFVTDETVDYVSEHPDVELWAYSPLVRGAYDRPDRPFPQAYRHLGTERRLAVLDDVAQAHGVARSVVVLAWLLASRPEVRPILGVSSVEQLESALRVADVDLAPDELAALDAPA
>NZ_CP011502.1|WP_144433658.1|881705_882914_+|PrsW-family-intramembrane-metalloprotease
MSQPHAQEAAPEVAGRGTIPRRMPRYVERPRQRGRTVLIVLTGIGVALGLVEVVVVAAGAEALEGARLAIIYALVPLPVLWFVYWWLDRYEPEPRRYKVAAFVWGGVGAVGIALAVQVLLGETTDLTQKELATFVAPASEEPAKGLFLLLTFLRWRRIIDGFLDGLIVAGLVGLGFAFVENIGYYALSYAGGPDVPIAGAEGAAGTFVVRGIASPFAHPLFLSAFGIALGLAVGIRSKVLKVLVGTLGLAISMALHGLWNGSASYFGGVGFALTYVALFVLFVTLAVVAIVARSRQVRTLERSLSYVAERGWIHPAEIPYLSRFGYRKQARRHARRHHGRVAGRIVRRYQRLATEMAFLHDAIMRGQTKPHGVERTYALLDAMYGLRPALRFPPPLPVAHRR
>NZ_CP011502.1|WP_067861325.1|883038_884745_+|dynamin-family-protein
MLGALSKLLTDVTAAPLALEVPGVDEVRSTRAEMVDQLSDYVIPRLVQLEAPLLTVVGGSTGAGKSTLVNSLVGEQVTQSGVLRPTTRSPVLVHHPDDAEWFQPDRILPELPRTKAVTNDVYALRLAPSTGVPRGLAILDAPDIDSIDAANRELATQLLAAADLWLFVTSAARYADQVPWDYLGRAAERSTSVAVVLDRTHADAVVEVRGHLARMMTSRGLSDSPLFTVPESAVGEDGLLPREAVEPIRGWLRDLAADPEGRSAVVFGTLDGAVRHNVLRSHVVADGLDEQLAAARQLHDDATRTYAEAVDLLRRATADGTVMRGEVLTRWQEFVGNGELLRSVEERVSRIRDRLVDQVTGKRTRSAEVSEAVESGLQTLLVEQLEAAAEAVYRSWSSVGAGRALIASERGLDRASRDVRVKAERLVRDWQAEVLELVRAEGSDKRLTAKFLAFGVNGIGVALMVLVFVSGSAGLTGAEVGVAGGTAVVAQKLLEAIFGDQAVRRLAERAHTSLVTAVEALATAESRRYLDLVSDPAVIEASQARLRDAARRAEYARHIDFLDGETAS
>NZ_CP011502.1|WP_083516247.1|884741_886403_+|50S-ribosome-binding-GTPase
MSERPGPVARATSALFGGERNDVAARLDGLGEAVEAARGRLDDTLLDPAAALAERASERLRLSGEHTIVALAGATGSGKSSLFNCLTDLELAGVGVRRPTTSWALACSWGPDGAQELLEWMGIPARHQVSRMSMLDRSSADTKLDGLVLLDLPDHDSTEVSHHLEMDRLVQYADLLIWVLDPQKYADAAIHDRYIRPMAAYRDVTLVVLNQIDRIHFSERERALGDVRAILDREGLPGVPVLGVSAHRGDGVDDLKRELARRIRAKASAKERLAQDIAASAAGIVTVGGRSDIPGITDIDRQALDLALLDSVGAPQLVEAVEASTLRTARRHTGWPPLRWVGRLRKDPLRELGIDPDGSIASLSRAVRPSVGHVQRAQAESAVREISEKAAVGLERPWRDAVREASVSTSADVVRELDETVDRIDLGLSRTPFWWRAVDVLQWLAFAALVVGVGWGAVELLSGLVGWEVGDAPVVAGTSLPLLLLLGGLVGGVLLAALSRAAVRTSARRRAQQADATLRRAVAEVSEQKVVAPLQAELDRYERYRSGILRALG
>NZ_CP011502.1|WP_067855106.1|886470_888153_+|energy-dependent-translational-throttle-protein-EttA
MADYVLSLRNVRKAHGDKVVLDDVTLSFLHGAKIGVVGPNGMGKSSLLKLMAGLDQPNNGDIVRDPEATVGMLQQEPPLTEGKTVLENVEEAVSEVKDKMKRLEEAYAEMGEPDADYDALMAETGDLQTFLDSVNAWDLDSRLDQAMDALRCPPPDELVDHLSGGERRRVALCKLLLQQPDLLLLDEPTNHLDAESVQWLEGHLKTYPGAVLAVTHDRYFLDNVAEWIAEVDRGRIHGYEGNYSTYLETKKERLKIEGAKDAKRAKMLEKELDWVRSNAKGRQAKSKARLARYEELAAEAERARKIDTSEINIPAGPRLGDVVLDAKSLSKGFEGRTLWDDISFSLPRAGIVGVVGPNGVGKTTLFRMITGNEVPDAGTLEVGQTVKISYADQSRGSIAADKNVWEVVSDGLDFIKVANFEMNSRAYVASFGFKGADQQKKAGVLSGGERNRLNLALTLKQGGNLLLLDEPTNDLDVETLSSLEDALLDFPGCAVVTSHDRWFLDRIATHILAWEGTEDEPGRWFWFEGNFASYEENKIERLGEEAARPHRVTHRRLTRD

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Crispr_ID: NZ_CP011502_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_12

2567030-2567156

Orphan

Consensus_repeat	Method
GGCGCATGTTTGCGTGGGGGCGAGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP011502_12

>merge|NZ_CP011502|12|2567030-2567156|CRISPRCasFinder
CGCGCACGTTTACGTGGGGCCCCACGCAAGCACGCACTTCTGGCGCATGTTTGCGTGGGGGCGAGCCGGTTTACGTGGGGCCCCACGTGAACGTGCACCTACGGCGCATGTTTGCGTGGGGGCGAGC

>NZ_CP011502|12|12|2567030-2567156|CRISPRCasFinder
CGCGCACGTTTACGTGGGGCCCCAC	GCAAGCACGCACTTCT
GGCGCATGTTTGCGTGGGGGCGAGC	CGGTTTACGTGGGGCCCCACGTGAACGTGCACCTAC
GGCGCATGTTTGCGTGGGGGCGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067859037.1\|2571973_2573188_-\|phytanoyl-CoA-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|227609
NZ_CP011502.1\|WP_067859005.1\|2556395_2557745_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	unknown	unknown	gnl\|CDD\|223362
NZ_CP011502.1\|WP_067859011.1\|2561169_2561682_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_169795983.1\|2570465_2571050_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
NZ_CP011502.1\|WP_067859014.1\|2561678_2561993_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_083516425.1\|2557907_2560076_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP011502.1\|WP_067858999.1\|2555327_2556014_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|225040
NZ_CP011502.1\|WP_067859042.1\|2574471_2575260_-\|TIM-barrel-protein	unknown	unknown	gnl\|CDD\|226149
NZ_CP011502.1\|WP_067859023.1\|2564420_2567018_+\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|380147
NZ_CP011502.1\|WP_083516426.1\|2575261_2576287_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|275173
NZ_CP011502.1\|WP_067859017.1\|2561989_2563768_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|283837
NZ_CP011502.1\|WP_067859002.1\|2556054_2556399_-\|DUF4233-domain-containing-protein	unknown	unknown	gnl\|CDD\|379420
NZ_CP011502.1\|WP_067859040.1\|2573316_2574348_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380530
NZ_CP011502.1\|WP_144433766.1\|2563776_2564301_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237276
NZ_CP011502.1\|WP_067859026.1\|2567203_2568361_-\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225807
NZ_CP011502.1\|WP_067859031.1\|2569866_2570469_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|237133
NZ_CP011502.1\|WP_067859045.1\|2576492_2577476_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP011502.1\|WP_067859034.1\|2571200_2571974_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|180462
NZ_CP011502.1\|WP_067859008.1\|2560108_2561104_+\|DUF2332-domain-containing-protein	unknown	unknown	gnl\|CDD\|378386
NZ_CP011502.1\|WP_067859029.1\|2568458_2569733_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	unknown	unknown	gnl\|CDD\|235422

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067859037.1\|2571973_2573188_-\|phytanoyl-CoA-dioxygenase-family-protein	gnl\|CDD\|227609	COG5285, COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism].	3.80167e-34
NZ_CP011502.1\|WP_067859005.1\|2556395_2557745_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	gnl\|CDD\|223362	COG0285, FolC, Folylpolyglutamate synthase [Coenzyme metabolism].	6.45253e-134
NZ_CP011502.1\|WP_067859017.1\|2561989_2563768_+\|hypothetical-protein	gnl\|CDD\|283837	pfam06259, Abhydrolase_8, Alpha/beta hydrolase. Members of this family are predicted to have an alpha/beta hydrolase fold. They contain a predicted Ser-His-Asp catalytic triad, in which the serine is likely to act as a nucleophile.	2.29344e-25
NZ_CP011502.1\|WP_169795983.1\|2570465_2571050_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.77949e-113
NZ_CP011502.1\|WP_067859040.1\|2573316_2574348_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380530	cd06307, PBP1_sugar_binding, periplasmic sugar-binding domain of uncharacterized transport systems. Periplasmic sugar-binding domain of uncharacterized transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily. The members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes.	9.14286e-79
NZ_CP011502.1\|WP_083516425.1\|2557907_2560076_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	9.37471e-81
NZ_CP011502.1\|WP_067858999.1\|2555327_2556014_-\|metallophosphoesterase	gnl\|CDD\|225040	COG2129, COG2129, Predicted phosphoesterases, related to the Icc protein [General function prediction only].	5.20256e-17
NZ_CP011502.1\|WP_067859042.1\|2574471_2575260_-\|TIM-barrel-protein	gnl\|CDD\|226149	COG3622, Hfi, Hydroxypyruvate isomerase [Carbohydrate transport and metabolism].	3.93022e-78
NZ_CP011502.1\|WP_067859023.1\|2564420_2567018_+\|valine--tRNA-ligase	gnl\|CDD\|380147	NF000540, alt_ValS, valine--tRNA ligase.	0
NZ_CP011502.1\|WP_083516426.1\|2575261_2576287_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|275173	TIGR04380, hypothetical_protein_HOLDEFILI_04020, inositol 2-dehydrogenase. All members of the seed alignment for this model are known or predicted inositol 2-dehydrogenase sequences co-clustered with other enzymes for catabolism of myo-inositol or closely related compounds. Inositol 2-dehydrogenase catalyzes the first step in inositol catabolism. Members of this family may vary somewhat in their ranges of acceptable substrates and some may act on analogs to myo-inositol rather than myo-inositol per se. [Energy metabolism, Sugars].	4.94091e-85
NZ_CP011502.1\|WP_067859002.1\|2556054_2556399_-\|DUF4233-domain-containing-protein	gnl\|CDD\|379420	pfam14017, DUF4233, Protein of unknown function (DUF4233). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 147 amino acids in length. Proteins in this family are integral membrane proteins.	2.89285e-24
NZ_CP011502.1\|WP_144433766.1\|2563776_2564301_+\|hypothetical-protein	gnl\|CDD\|237276	PRK13024, PRK13024, bifunctional preprotein translocase subunit SecD/SecF; Reviewed.	0.00982142
NZ_CP011502.1\|WP_067859026.1\|2567203_2568361_-\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	gnl\|CDD\|225807	COG3268, COG3268, Uncharacterized conserved protein [Function unknown].	1.05705e-39
NZ_CP011502.1\|WP_067859031.1\|2569866_2570469_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|237133	PRK12553, PRK12553, ATP-dependent Clp protease proteolytic subunit; Reviewed.	7.0524e-115
NZ_CP011502.1\|WP_067859045.1\|2576492_2577476_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.20209e-77
NZ_CP011502.1\|WP_067859034.1\|2571200_2571974_-\|SDR-family-oxidoreductase	gnl\|CDD\|180462	PRK06198, PRK06198, short chain dehydrogenase; Provisional.	1.57274e-131
NZ_CP011502.1\|WP_067859008.1\|2560108_2561104_+\|DUF2332-domain-containing-protein	gnl\|CDD\|378386	pfam10094, DUF2332, Uncharacterized protein conserved in bacteria (DUF2332). Members of this family of hypothetical bacterial proteins have no known function.	1.91811e-71
NZ_CP011502.1\|WP_067859029.1\|2568458_2569733_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	gnl\|CDD\|235422	PRK05342, clpX, ATP-dependent Clp protease ATP-binding subunit ClpX.	0

>NZ_CP011502.1|WP_067859023.1|2564420_2567018_+|valine--tRNA-ligase
MTTAQNRVPAKPALEGLEERWSGVWAEQGTYAFDRTKSRDEVYSIDTPPPTVSGSLHVGHVFSYTHTDLVARYQRMSGKEVFYPMGWDDNGLPTERRVQNYYGVRCDPSLPYDADFTPPAKPDTGSKSGGKQVPISRRNFIELCNELVVEDEKVFERLWRTLGLSVDWSQTYTTIGADAQATSQRAFLRNVGRGEAYMQDAPTLWDVTFQTAVAQAELEARDYPGAYHRVAYHLPDGSTVHVETTRPELTPAAVALIAHPDDERYSHLFGGTATSPLFGVEVPIHSSTLADPEKGSGIVHCCTFGDLTDVQWWRELQLPNRTVIGRDGRVLRDVPEWIAGGPGEQLWAELAGKTTFSAREAIVQALRDSGDLDGEPQPTQRVANFYERGEKPLEIVSTRQWYVKNGGRDADLRAALVARGDEIHWTPGYMQSRYTNWIEGLNGDWLISRQRFFGIPFPVWYRLDAEGQPDYDEPIFAAEDTLPVDPASQAPPGFEESQRGQAGGFVADPDVLDTWATSSLTPQIVCGWERDADLFERTFPMDLRPQGHDIIRTWLFSTVVRSHQEFGQVPWSHTALSGFVVDPDRKKMSKSKGNVVVPDEILDKYGADAVRWRAALARPGSDSPFDETQMKVGRRLAMKVLNASKFVLAAPEDYGLGATAADLDLARVTEPLDRSVLAALGRVVEQATAHFEAYDYSSALEVTEKFFWDFCDDYLELVKERARRDDEGGTSAKATFVLALSTQLRLLAPFLPYVTEEVWSWWQEGSVHRAAWPSVDDVAVDGDVALLPTAAEALAGIRGAKSVAKVSQRTEVSAVTVRGPQTSLDRLLLAVDDVRAAGRVTGELTTSADDSTTELVTDATLAPTE
>NZ_CP011502.1|WP_144433766.1|2563776_2564301_+|hypothetical-protein
MRGMIAMGLLALLLSACGGGDDDVPEGREGLSVIKTRADRGLAEATDAVGAVVRAEPRDVRGAYVQAGSSGSTLLYAYEAQATFRTQQPVDPEEVRTTLVDLGLETSEVLDGLDGGRSITASADDHVVSVDLDAGRTRLTLTSQTSGAELQASTLSTEEKADLREPKPLSLDLD
>NZ_CP011502.1|WP_067859017.1|2561989_2563768_+|hypothetical-protein
MSTVTITIPAAPVAVAPVPGDAAALRDFAADLLTVSSGLDDLATFAGDVLSGEHWEGEAAEAYRRAAVGTADDADDRSLVLRKVSGQVEDYATGLADRKRRRDGLVERRSTLLSRREDLTADVRAAVDVSDEAIQTLQQRAEQLRLDVEAFDRDHADLQQDCRTADEQIAQKLQAVDSSAEVTRAAVGLVDPADALLDRPGAPGTDGATPASVHDWWTSLDASQQQALIAAHPQIIGNTDGIPTAARDEANRISLALDLDRLETREDDGGSLTFAERRHLERAQAAQTALDDVAARRDPVTNEPLEGFLSLYDPTAFGGDGAVAVSVGNPDTAQNVSVSVPGMLNDGASIEGGTESVGNLYATARLANPGQSVASTMWIGYDAPSNFGVHGLDTLQVIDEGLADAGGERLADFLDGMREVRDEDVHGRAHLTVIGHSYGSTTVGNAATDHGIPADDVVLIGSPGAGHAADHATDLGLPAAHVWAGSASEDAVSHLARNGWVGTGLGLDPTDEDFGAQRFQAENVARGTHDWIWDHNQYYQPNTESLYNMGQIVAGNDDAVLDAEHRHDPWYGPMQDPEEDRQPARRDTGFEP
>NZ_CP011502.1|WP_067859014.1|2561678_2561993_+|hypothetical-protein
MSGAWSVQPGSLMRASTDWRDRADALEGTAKRLRLADQSGFPPSVEGAAAAFVREWATMVDDLAETARDFEDRMMEAHGAYVESDVRSQESFQEWLLQMGGGER
>NZ_CP011502.1|WP_067859011.1|2561169_2561682_+|hypothetical-protein
MSEPGGREPFWDVVRRRHPDVDVVLLPPAEATAPPGSDRDPVSVETAQELAARLDQEFASVWELLLGGPPEPSPVRWTSSPVPGTARPVRSQRSRDERGEDLVGTSRAVLTDLGWTTSEPQAGLPLLVAERDDRDLRLTVHDGAVLLEVHGPAVPVRPRTLRALRAEARS
>NZ_CP011502.1|WP_067859008.1|2560108_2561104_+|DUF2332-domain-containing-protein
MEHGQELAEEYREFAAQAADSATFMAWSAAVADDAEVLDWLATLPRAKQQPNLVLAAARLHGVPAPGPYAALREALLADGSDGPIRATVLERSTQTNEVGRLATLAPAFAIVAAQHDDAPLSLLEVGASAGLCLYPDRYTYRWRTEGGDVVVGTGPGLACDVTGPAPLPQRVPRVAARRGIDLNPLDVTSPDDVAWLETLVWPEHDDRRARLRAALEVARADPPHVVAGDLLTELPQLVEEAAADGPVVVLHSAVIAYLDDHQRVAFDELARGLVADGACHWVSNESSRVLPSITATASSPGPERHAFVLGLDGQAVAGAHGHGRTLHWLA
>NZ_CP011502.1|WP_083516425.1|2557907_2560076_+|MMPL-family-transporter
MSRQASSWIVHRFGTWGALVVLLVLLGGLGSFGSRLGEVQRNDAASFLPGGAESTRVIDQASTFADPDVVPAVVLLVRDGGARPDDVQRLAALKERLASLPGVTGDVIGPIPSQDREAAQLVVNLRVDPDEGFEQLPDTVDELRDVAAQDAGGADVYVAGPAALAADQAQAFAGIDGILLIAAISVVVVMLLLTYRSPVLWIIPLFCGVLSVFAAQGVVYLLAKYADLTVNGQSAGILSVLVLGAGIDYALLIVARYREELRNTEDRHAAMAHALHRAAPAVLASGSTVVVGLLCLLLAQMQATAGLGPVAAAGIVVALLTMLVLLPALLVVCGRWVFWPFVPRFGDPQPAEDGVWGRVGRRIARRPRAVWAVTTLLLAGFTVGLVQLDANGLSDAEQFTTEQPSIVAEGKLAEHFPGGAGAPVQVVVDAAHVDDAASTLQGVQGIAPDSVSEPVVRGDVGYVEGTLEAAPDSRAAFDTVDRARAALADVPGDPLVGGTTAINHDVQQASAADTRLIIPVVLLAVLLILGVLLRSVMAPLVLLVTVVLSFGAALGISALVFRHVLGFGGTDSSFPLYAFVFLVALGIDYNIFLMTRVREESLVHGTRRGALIGLAATGGVITSAGLVLAGTFAALGSLPIVFLAELGFAVALGVLLDTLVVRSVLVTALTLDLGRWMWWPSALFRTDGGHASSTGHPVAHHAADAAHPADHVAGHHAPDHRD
>NZ_CP011502.1|WP_067859005.1|2556395_2557745_-|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase
MSNPTYAEVEAALLGRWPETRLEPSLERITALCRLLGDPQDAYPVVHLTGTNGKSSTARMVDALLRALDLRTGRFTSPHLQSMTERISLDGEPLTEEQFVEAFADVAAYAQVVDDSQPHPVSFFELTVAMAFAAFADAPVDAAVVEVGMGGSWDATNVAHGKVAVVTPVAVDHARYLGDTAAEVAVEKSGIIKAGSHAVLAAQEPDVLDVLVRRSLEVGATVLREGVDFGVVERLNAVGGQQVALQGLNARYDDVLLRLHGAHQAQNAAVALATVEAFVDAELDGDLVRAAFGEVTSPGRLEVLRRSPTVLVDSAHNPHGVRAAVETVQDAFTFSPLVGVVGAMADKDVEEMLRELEPVLAHVVCTQNSLDRSMRAEELGELAEEVFGEDRVTVVRSLDDALVRAIAMAETGEGMEEAIGSGGVLVIGSVVTAGEARILLGGGPAGGAA
>NZ_CP011502.1|WP_067859002.1|2556054_2556399_-|DUF4233-domain-containing-protein
MRGMCAAMLTFEAILLGLSTPVMITVEDVPASTALPLGLGLAVLCILTAGMLRRPWGYTVGHLIQVASVALGFLVPAMFFVGGMFALLWVSAFVLGRRIEEDKRRWAEEGPDPV
>NZ_CP011502.1|WP_067858999.1|2555327_2556014_-|metallophosphoesterase
MVRVLAVSDEVVDSIHHPQVRRLAPDLVVGTGDLPWDYLEFLASALDVPVVFVPGNHDPEVVTRATGWRAVLTGDGMPHADPRPIGCRSADGRVVEAAGLRIAGLGGSIRYSNGANQYTQRQLARRARRLLRRAGEEPVDLLLTHSPPSGLGDEDDPPHRGFDALRQVLDVLRPTWHLHGHVHPYGMAKPDRHVGPTTLRNVIPYQLIDVEPVRRPVGVAVEGDSDGQ
>NZ_CP011502.1|WP_067859026.1|2567203_2568361_-|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein
MTVDITLFGATGFTGTLTAVYLGTHLPEGGTWAVAGRSAAKLQNVVDEVEAAGGTAPEIVLADVSDAASMRAMAEGTRVLISTVGPYVQHGDPAVRAAAEAGIAYVDLTGEPEFVDRTWLEHQETALRTGATLVHACGFDSIPYDLGVLYTVEQLPEGVPIDVKGYIRAGGTASGGTYHSAIGAFSRLRQSAATAKERKQREQRPQGRSVRGGGSIGRGAGGKGWALPLPTIDPQVVLRSARALERYGPQFTYSHFAQFTKLPVLAGTVVGAGVLLAGSQLAPTRKALLKLRAQGDGPSPEKRASSWFSLRLVGEGGGKRVVTQVSGGDPGYDETAKMLSESALCLAFDDVPKVAGQTTTAVAMGRPLIERLQAAGIRFETLETA
>NZ_CP011502.1|WP_067859029.1|2568458_2569733_-|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX
MARIGETADLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAEGAELSLGELPKPHEIFEFLNGYVVGQDNAKKNLAVAVYNHYKRVQAQATTGRAKDDGVELAKSNILMVGPTGCGKTYLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEVDKISRKAENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFAGLEEIIEQRSGKVGLGFNTGGVAEKKPETAPEKLFSQVLPEDLLKFGLIPEFIGRLPVIAAVDKLDKPALVSILTEPRNALTKQFVRLFELDDVELEFTDDACEAMADLALARDTGARGLRSIIEHVLQPVMYDIPSRDDVAKVVVTGATVRGEEGPTVLTRDEVAKKAS
>NZ_CP011502.1|WP_067859031.1|2569866_2570469_-|ATP-dependent-Clp-protease-proteolytic-subunit
MSYYIPQWEERTSYGFRRIDPYAKLFEDRIIFVGTPISDDVANAVMAQLLCLQQMDADRDIQLYINSPGGSFTAMTAIYDTMRYLKSDVQTVCLGQAASAAAVLLAAGTPGKRYALPNSRILIHQPYTEGTGGQISDLEIQANEILRMRSLMEQMIADATGKTPEDVSKDVERDKILTAEQAKEYGIIDQVFDSLKTPAV
>NZ_CP011502.1|WP_169795983.1|2570465_2571050_-|ATP-dependent-Clp-protease-proteolytic-subunit
MMAGTDVGPSDLDGHIYQRLLRERIIFLGSEVRDSNSNAICAQMLLLNAEDPNADIFLYINSPGGSVDSGMAIYDTMQFISNDVATVAMGLAASMGQFLLAAGAPGKRYALPHARIMMHQPSGGIGGSASDIKIQAQQSILLKKQLNELQSLHTGQSIEQIEADADRDRWFTPDQAKDYGFIDQVIKSAGEVAR
>NZ_CP011502.1|WP_067859034.1|2571200_2571974_-|SDR-family-oxidoreductase
MGSLDDRVVLVSGGTQGVGLAIAQAALREGARVVVTGRRADVGEAAAADLSALGDARFVRCDVADVEACRAAVEATVTAHGRVDGLVNAAGFTERGSVLDTTPEMFEQHVAVNLRGPFFLMQAAIGDMVRRGEPGSVVNVLTMSAHGGQPHLAPYSATKAGLAGLTKNAAYAHRFDRVRVNGVNIGWTDSDGEDVIQRRFHDAGDDWREQAAKRLPAGRLATPEDAAGIVVLLLSDASGVVTGSVMDWDQTVVGTSD
>NZ_CP011502.1|WP_067859037.1|2571973_2573188_-|phytanoyl-CoA-dioxygenase-family-protein
MSLVDHTAPADRGAARRARFTPDDVRLADLVEVVSEPTRADDYPHAAGVEQGVVVYASVTLRAAVASPEGEDAVRAELVHALTDGPGIVVLKGAWDDHDVVDRATAAFEEVIAQEKAAGGAAGDHFAKPGANDRIWNALEKLAVTDPATFVDYYANDVLALVSTAWLGPAYQVTSQVNVVRPGGVAQDPHRDYHLGFLSDEVAARYPAHVHLLSPVLTLQGAVAHVDMPVESGPTLYLPHSQKYGPGYLAYRRDDVRDYFADHHVQLPLEKGDAVFFNPALLHGAGSNVSADVQRVANLLQVSSAFGRAMEAVDRARATTAVYPTLLERRAAGWSDAALRRVVASVAEGYPFPTNLDLDQPVDGMTPLSQAEIVEQALAAGRDVDQVGQALGAYAARRRTDGAV
>NZ_CP011502.1|WP_067859040.1|2573316_2574348_+|LacI-family-DNA-binding-transcriptional-regulator
MPHRHKVREIAQQSGLSEATVDRVLHGRPGVRAATVAEVERAVEELDRQASQLRLVGRTFLLDLVMQAPVRFSTAVRAALEAELPSLRPAVVRSRFHLREEAGVAAMVATLRDVRRRRSHGVVLKAPDHPDVAAEVAALADAGVPVVTLVTDVPRSRRLAYVGIDNDAAGRTAAYLVAQGAPASGAVLVTLSRSDFRGEEQRVSAFVDALHDLSPARRVVDLTDTDGLDPTTGAGVRAALADHPDVDAVYSVGGGNRATLEAFADAGRAPRVFVAHDLDADNTELLRTRRVHYALHHDLRADTRRACRLLLQHHGALPGAPTSVPSQVQVVTPFNLPRAFTTP
>NZ_CP011502.1|WP_067859042.1|2574471_2575260_-|TIM-barrel-protein
MSFTLAICSEMVLTELPHLERVQHIHDAGFAVEIWDWTQKDAEALRATGASFTSMTGYVTGDLTTPGGADDLLRTAEESIPFAQAIGCPSLNIHGTGLGEGGLPVRPVEVTTGEDWVAAVRTLERVAELAERHDVTYVLENLNTAVDHPGTPFARAADTLALVRAVDSPHLRMNLDLYHAQIGEGNLVDLVREAVPFTGEVQVADVPGRCEPGTGEVRWSFVAQALADAGYTGVVAMEAWASDPSVDGSRRAMDAFREAFTV
>NZ_CP011502.1|WP_083516426.1|2575261_2576287_-|Gfo/Idh/MocA-family-oxidoreductase
MTSTPVRVALVGAGRIGAAHAETLARRVPDAHLVAVVDPRPGAATAVATPLGARAETEVDAVLGAADVDAVVVAASSVAHRDLVVAAADAGKHVFCEKPAGMSLVEIDEARRAATAAGVVFQVGFNRRFAREFAQARDLVESGTLGEVRQLRSLTRDPGRGPSDPDVVPPWTIFTQTLIHDFDTLNFLNPGAHAVDVVATADSLLFPGHATLLDHATVVVRYSNGALGTAEASFAAVYGYDVRGEVLGSEGMVTMGEGASSSLRVHGQGGRTASTAHSDTELLRDAYAAELAELCAAVREGRPPAVGADEAFAAFAVAQACIDSMTTGGRAAVATSVLQEA
>NZ_CP011502.1|WP_067859045.1|2576492_2577476_+|LacI-family-DNA-binding-transcriptional-regulator
MARTTLADVAREAGVSVALVSIVMRDAPGASDVTRARVRDVADRLGYVPDQRARLLRSTDTRLLGVTFDLHQPFHGDLVEHLYAAAAEHGYDVAISAVAPSRDERSAVQALRRERCDALVLLGPDLSTDDLAALGTDLPTLVVARRSGTPEVAAVRGDDELGVGLAVDHLVSLGHVRLAHVDGGSAPGAEERRRGFVEAARRHGLDPWVLAGGATERDGVRATATLLEASTPPTGVVAFNDHCASGVLDALLRARRDVPRQVSVTGYDDSRLAVARQDLMTTVSQSAREMAERAVAGALGLLAGEPARDVVLTPELVVRSTTGPAPA

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Crispr_ID: NZ_CP011502_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_13

2787248-2787333

Orphan

Consensus_repeat	Method
TGTTGGCGTGGGGCCCCACGCAAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011502_13

>merge|NZ_CP011502|13|2787248-2787333|CRISPRCasFinder
TGTTGGCGTGGGGCCCCACGCAAACCAGCTCCGCCCCACGCAAACATCGCGCGCATCTGCGTGTTTGCGTGGGGCCCCACGCAAAC

>NZ_CP011502|13|13|2787248-2787333|CRISPRCasFinder
TGTTGGCGTGGGGCCCCACGCAAAC	CAGCTCCGCCCCACGCAAACATCGCGCGCATCTGCG
TGTTTGCGTGGGGCCCCACGCAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067859584.1\|2781967_2784151_-\|methylmalonyl-CoA-mutase	unknown	unknown	gnl\|CDD\|236508
NZ_CP011502.1\|WP_067859579.1\|2781617_2781905_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067859592.1\|2787355_2787880_-\|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl\|CDD\|100051
NZ_CP011502.1\|WP_067861797.1\|2795754_2796132_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_CP011502.1\|WP_083516444.1\|2786117_2787227_+\|phosphoserine-transaminase	unknown	unknown	gnl\|CDD\|130433
NZ_CP011502.1\|WP_067859604.1\|2794756_2795758_-\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NZ_CP011502.1\|WP_083516446.1\|2793390_2794236_-\|dioxygenase	unknown	unknown	gnl\|CDD\|153375
NZ_CP011502.1\|WP_067861789.1\|2790786_2791008_+\|DUF2530-domain-containing-protein	unknown	unknown	gnl\|CDD\|378488
NZ_CP011502.1\|WP_067861786.1\|2787902_2789333_-\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NZ_CP011502.1\|WP_144433786.1\|2778535_2779207_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_144433787.1\|2779825_2780521_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372652
NZ_CP011502.1\|WP_067859601.1\|2794315_2794711_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP011502.1\|WP_083516445.1\|2791864_2793388_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP011502.1\|WP_067859577.1\|2780531_2781503_-\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl\|CDD\|236515
NZ_CP011502.1\|WP_067859572.1\|2779215_2779815_-\|MazG-family-protein	unknown	unknown	gnl\|CDD\|237065
NZ_CP011502.1\|WP_067859598.1\|2791026_2791761_-\|DUF3027-domain-containing-protein	unknown	unknown	gnl\|CDD\|378605
NZ_CP011502.1\|WP_067859587.1\|2784147_2786016_-\|methylmalonyl-CoA-mutase-small-subunit	unknown	unknown	gnl\|CDD\|239649
NZ_CP011502.1\|WP_067859596.1\|2789419_2790511_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378826
NZ_CP011502.1\|WP_067859566.1\|2776028_2777306_-\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NZ_CP011502.1\|WP_083516443.1\|2777658_2778537_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067859584.1\|2781967_2784151_-\|methylmalonyl-CoA-mutase	gnl\|CDD\|236508	PRK09426, PRK09426, methylmalonyl-CoA mutase; Reviewed.	0
NZ_CP011502.1\|WP_067861789.1\|2790786_2791008_+\|DUF2530-domain-containing-protein	gnl\|CDD\|378488	pfam10745, DUF2530, Protein of unknown function (DUF2530). This family of proteins with unknown function appears to be restricted to mycobacteria.	0.00034875
NZ_CP011502.1\|WP_067859592.1\|2787355_2787880_-\|gamma-carbonic-anhydrase-family-protein	gnl\|CDD\|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	2.75509e-77
NZ_CP011502.1\|WP_067861797.1\|2795754_2796132_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	2.89405e-09
NZ_CP011502.1\|WP_083516444.1\|2786117_2787227_+\|phosphoserine-transaminase	gnl\|CDD\|130433	TIGR01366, Putative_phosphoserine_aminotransferase_PSAT., phosphoserine aminotransferase, putative. This model represents a putative variant form of the serine biosynthesis enzyme phosphoserine aminotransferase, as found in Mycobacterium tuberculosis and related high-GC Gram-positive bacteria. [Amino acid biosynthesis, Serine family].	0
NZ_CP011502.1\|WP_067859604.1\|2794756_2795758_-\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	1.47168e-25
NZ_CP011502.1\|WP_083516446.1\|2793390_2794236_-\|dioxygenase	gnl\|CDD\|153375	cd07363, 45_DOPA_Dioxygenase, The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine. This subfamily is composed of plant 4,5-DOPA Dioxygenase, the uncharacterized Escherichia coli protein Jw3007, and similar proteins. 4,5-DOPA Dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA Dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain. Homologs of DODA are present not only in betalain-producing plants but also in bacteria and archaea. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon.	1.5765e-89
NZ_CP011502.1\|WP_067861786.1\|2787902_2789333_-\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	4.67962e-113
NZ_CP011502.1\|WP_144433787.1\|2779825_2780521_-\|hypothetical-protein	gnl\|CDD\|372652	pfam13624, SurA_N_3, SurA N-terminal domain. This domain is found at the N-terminus of the chaperone SurA. It is a helical domain of unknown function. The C-terminus of the SurA protein folds back and forms part of this domain also but is not included in the current alignment.	0.000695713
NZ_CP011502.1\|WP_067859601.1\|2794315_2794711_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	9.01796e-20
NZ_CP011502.1\|WP_083516445.1\|2791864_2793388_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.83489e-23
NZ_CP011502.1\|WP_067859577.1\|2780531_2781503_-\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl\|CDD\|236515	PRK09435, PRK09435, methylmalonyl Co-A mutase-associated GTPase MeaB.	1.69926e-177
NZ_CP011502.1\|WP_067859572.1\|2779215_2779815_-\|MazG-family-protein	gnl\|CDD\|237065	PRK12334, PRK12334, nucleoside triphosphate pyrophosphohydrolase; Reviewed.	5.32874e-68
NZ_CP011502.1\|WP_067859598.1\|2791026_2791761_-\|DUF3027-domain-containing-protein	gnl\|CDD\|378605	pfam11228, DUF3027, Protein of unknown function (DUF3027). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.47475e-97
NZ_CP011502.1\|WP_067859587.1\|2784147_2786016_-\|methylmalonyl-CoA-mutase-small-subunit	gnl\|CDD\|239649	cd03677, MM_CoA_mutase_beta, Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta heterodimers. For P. shermanni MCM, it is known that only the alpha subunit binds coenzyme B12 and substrates. The role of the beta subunit is unclear. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The reaction proceeds via radical intermediates beginning with a substrate-induced homolytic cleavage of the Co-C bond of coenzyme B12 to produce cob(II)alamin and the deoxyadenosyl radical. MCM plays an important role in the conversion of propionyl-CoA to succinyl-CoA during the degradation of propionate for the Krebs cycle. Methylobacterium extorquens MCM participates in the glyoxylate regeneration pathway. In M. extorquens, MCM forms a complex with MeaB; MeaB may protect MCM from irreversible inactivation. In some bacteria, MCM is involved in the reverse metabolic reaction, the rearrangement of succinyl-CoA to methylmalonyl-CoA. Examples include P. shermanni MCM during propionic acid fermentation and Streptomyces MCM in polyketide biosynthesis.	1.47531e-150
NZ_CP011502.1\|WP_067859596.1\|2789419_2790511_-\|hypothetical-protein	gnl\|CDD\|378826	pfam12200, DUF3597, Domain of unknown function (DUF3597). This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 126 and 281 amino acids in length. The function of this domain is unknown. The structure of this domain has been found to contain five helices with a long flexible loop between helices one and two.	0.000977164
NZ_CP011502.1\|WP_067859566.1\|2776028_2777306_-\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NZ_CP011502.1\|WP_083516443.1\|2777658_2778537_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	4.3946e-25

>NZ_CP011502.1|WP_083516444.1|2786117_2787227_+|phosphoserine-transaminase
MKIPARLLPQDGRFGSGPSKVRPEALAALAATGSSLLGTSHRAAPVKNVVASVRRGLGDLLELPDGYEVVLGLGGSHAFFDAAVHGLVERRSQHLVHGEFSRKFATAAARAPFLQEPDVLESAPSTHPLPRANPDVDVYAWAHNETSTGVMVPVERVPDADPDALVLVDATSAAGGLSVDVAQTDVYYFAPQKSFASDGGLWIAVMSPAAVERAERIAASGRYVPAFLDLPTAIENSRKDQTYNTPAVATLVLLDEQVRWLNEQGGMDFAARRVRDSSARLYEWAEASTFASPFVTAPTERSFVVGTIDLDASVPQKDLTGVLRENGVVDLDGYRGLGRNQLRVGMFPAVEPDDVSALTACIDWVVERL
>NZ_CP011502.1|WP_067859587.1|2784147_2786016_-|methylmalonyl-CoA-mutase-small-subunit
MASDLGSGVGPEATVAVPLADGVAPDVAAWEKATAAVLRKTKKLADDAPDADVWGLLTRRTLDGIGVTPLGTPALTADLPETGLPGQAPFTRGSAATRELDGWDVRAWFTDPDPDVTAEQVVTDLENGANSLWLSVGDGAIPTSALARVLEPVFVDLAPVVVEDPTDPLAAAQALDAVLDDKAVAPAPGTSYGADPLGAHARTVLGIGLEGAVTDPAVAVEVAHLAQRRGARGIVVDATAVHDAGASDVQELAYSLLAGAAYLRLLVEAGLDVDAAADQLDVRLAATDEQFPTIAKLRAARRTWARLLELSGVAETGRGQRQHVVTSRPMMASYDPYVNMLRTCVATFAAGVGGATSVTVLPFDEPLGLPEAFSRRIARNTSSLLISESHVARVTDPAGGSHAVEKLTDDLARSAWELFGELDAAASDGGLVAALEVLRPKVEQTVSDRALDIARRKRPVTGVSEFPNLHEELPQRRPYGRTQPVLRYAREFEAMRDDRAAQPVFLATLGRVAQHTARATFAANLFAAGGIDTVTAGATDGVEAVVEAYRQADAPAVVCLAGPDPLYAEWGGDLVAALREAGARHVVLAGKPESVDADVDDSCAAGLDALAFLRRTREEVTA
>NZ_CP011502.1|WP_067859584.1|2781967_2784151_-|methylmalonyl-CoA-mutase
MTIPASFAGLPLDPDEPTTPDPAAYAAAVDGAEPWDAPEGIAVKNLYTADDLADVDALDTYPGLAPFLRGPYPAMYTTQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVKGDVGMAGVAIDSIYDARQLFDGIPLDEMSVSMTMNGAVLPVLALYIVAAEEQGVTPEQLSGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFAYTAAKMPRFNSISISGYHIQEAGATNDLELAYTLADGVEYIRAGLDVGLDIDAFAPRLSFFWAIGMNFYMEIAKMRAARALWARLVRDFDPKNPKSLSLRTHSQTSGWSLTAQDVFNNVQRTCIEAMAATQGHTQSLHTNALDEAIALPTDFSARIARNTQLLLQQESGTTGVIDPWGGSYYVEKLTHDLANRAWAHIQEVEKAGGMAKAIEAGIPKMRVEEAAARTQARIDSGQQAVIGVNTYRLADEDPLDVLKVDNASVYAQQVAKLERLRAERDPQEVERALDALTASAERGASRDGSLDGNLLALAVDAARAKATVGEISYALEKVYGRHQAVIRTISGVYRTEAGQGGNVQKVIDATEAFEKAEGRRPRILVAKMGQDGHDRGQKVIVTAFADMGFDVDVGPLFSTPEEVAQQAVDADVHIVGVSSLAAGHLTLLPELKKALAELGGEDVMVVMGGVIPPDDVPTLKEMGAAEVFLPGTVIADSALSLLERLRASLQH
>NZ_CP011502.1|WP_067859579.1|2781617_2781905_+|hypothetical-protein
MNEPQVWTAIGILGTSLFGMLTLMSTMFVRIIRTEIGSVRTEIGSVRTEIGSVRTEIGSLRTEMQAEFASVRTEIRYLDRDVQVLTKRVFGDGAA
>NZ_CP011502.1|WP_067859577.1|2780531_2781503_-|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MVDVEKLAADVLDGRRAGVSRAITLVESSRADHRAAARELLAALAPHAGGAVRVGISGVPGVGKSTFIEALGTHLVEQGNRVGVLAVDPSSVRTGGSVLGDKTRMAQLAVSPQAYIRPSPSAGTLGGVARATSQAMTVLEAAGYDVVLVETVGVGQSEITVAGMVDTFLFLTIARTGDQLQGIKKGILEIADVIAVNKADGERAREAEVTAKDLAGALRLVYAGTQGWVPPVVTCSALEHQGIDTVWNRLVRHREFLGQRGLREKRAQQQLDFTWALVRDELDQRLRTDEGVARVRDEVREAVLSGELPAASAADLILEAYDQ
>NZ_CP011502.1|WP_144433787.1|2779825_2780521_-|hypothetical-protein
MRSRPVMPVTRRRSRSAGALVPPLTLSAVLLAGCGGSISPGAAATVDGTTITMAQADRTADVLCEVSLFSAAQSGGGSTIDNADVRRQAVSELVSGVVAREVAAREGIRVPRSAYVFTGEQRAQVEQALPDVDVDEAVRVLEAGQRTYAIAEKLGEAATGQRADDTNAQQLQQAGRSVLADALRKADVSIDPRFGLGDDGQQVAATGSLSVPAAADTRDRPLIAPATQRCS
>NZ_CP011502.1|WP_067859572.1|2779215_2779815_-|MazG-family-protein
MSDPRPGERLLDLVAVMARLRAECAWTGQQTHESLSRYLLEETYETLEALDDGDTDLLREELGDLLMQVVFHAAVAADTGEGWDVDDVAAGITDKLVRRNPHVFADGTARTPEEIDAAWQAVKAQEKAASGAREAHPLDGIARDLPALATARKALDRVPDLDTSGDDLGSRLLRLVAEAREQGVDAEEALRRAVRDRLA
>NZ_CP011502.1|WP_144433786.1|2778535_2779207_+|hypothetical-protein
MTWTRGRLVGVACAALSVLLLVGVGVTYVLSTRAAVDVRVTPASLQCIRPSDDAYRPMPWVVDTTQIPGKDATSTAAFAERGEPRDPGFFLTVDTRDMQCTMVLDVTNRGSIPVKVRAVRFYGWADEPSTRDDWVVSDEGTGAAVRAVGEERQDAAYVVDETLGAGDFARVEMDFQRRHGVCRSGGQFVSRQRPEIEVSTLGWRSSLDSDLTLATWFVPSLMC
>NZ_CP011502.1|WP_083516443.1|2777658_2778537_-|M23-family-metallopeptidase
MLDAPTRVGTASAISILSAQARRACPRRVLLPGKAVATPGPLEGADLLIDTVLIDRDRPSPPTSSLLVQATRISQQFRSARRNDRDHRRRFYSDEDGIPMRKITTVRTAAATLALCAAAGLTTAATAAAAPASGSNDPGANRPALEVPFPCGDVWSGQTRGADDPHPHNPLLAIDFNLPTGGDSDLGRWVQASNAGTVTFAGNKGPGYGNTVDIYHKGGWSTRYAHLKEIAVDKGQVVTARTGIGRVGKSGGQPSAHLHYEQRWNNDDQVIYFGNTKAKYWGTTNYTRKTLC
>NZ_CP011502.1|WP_067859566.1|2776028_2777306_-|phosphopyruvate-hydratase
MASIEAVGAREILDSRGNPTVEVEVALDDGTIGRAAVPSGASTGQFEAVELRDGGDRYLGKGVRKAVEAVNTTIAAEIVGFDADDQRAVDAAMIALDGTPNKAKLGANAILGVSLALSKAAADSAGLPLFRYVGGPNAHVLPVPMMNILNGGAHADSNVDVQEFMIAPIGAPTFAEALRQGTEVYHALKSVLKKDGLSTGLGDEGGFAPSLPSNRAALDLIATAVEKTGLTLGTDIALALDVASSEFFENGSYTFEAAPKTSGEMADYYAELVAAYPIVSIEDPLDEEDWDGWVALTERIGDQVQLVGDDLFVTNVERLTRGLEQGAANAMLVKVNQIGSLTETLDAVELAHRHGFSNMMSHRSGETEDVTIADLAVATNCGQIKTGAPARSDRVAKYNQLLRIEEALGSAAVYAGASAFPRLAL
>NZ_CP011502.1|WP_067859592.1|2787355_2787880_-|gamma-carbonic-anhydrase-family-protein
MLIDLGDDRRPRVAETAFVAPNATLVGSVLLEEGASVWYGAVLRADNEPITVGPRSNVQDGCAFHVDRGHPVVLGEGVSVGHNAVVHGATVEDHCLVGMGAVVMNGAVIGSESLVAAGALVTAGMQVPPRSLVAGVPAKVRRELSDAEVEGLHRNARIYEEHRELHRGATVVTP
>NZ_CP011502.1|WP_067861786.1|2787902_2789333_-|NCS2-family-permease
MLERHFKIAARGSSVGREVRGGVVTFLTMAYIIVLNPIILAGVPDADGNFLGGGSEPGSGFTTIAACTALAAGVLSILMGAVANFPLAIATGLGLNAFVAYSVASQMTWADAMGLVVIEGLVILLLVLTGFRKAVFDAVPAQLKTAIAVGIGLFITLIGLVDAGFVRTTGNAAPPIGLGIGGELAGWPVLVFCLGLLLMIALHARGVPGAILIGILATTVLAGVVQAITDTPGGGGDPTSKGWNLNVPSLPDTIVQTPDFSLLGQFSLLGSFERVGVVAASLLVFTLLLADFFDTMGTMTAIGAEAGLNDEGGSPEGAQRILVVDSIAAAAGGAAGVSSNTSYIESAAGVGDGARTGLASIVTGVLFLLATFFAPLVQHIPNEAAVPALVLVGFLMMSQVTGISWDDPDIAIPAFLTIVLMPFTYSITAGIGAGFIAWVVLRVTRGRIASIHPLMWVVTALFVIYFAIDPITRWLT
>NZ_CP011502.1|WP_067859596.1|2789419_2790511_-|hypothetical-protein
MNPRRRRLLFPALLVVLLVVAAVVSLARDADARPLDPSSLGALPAPATLSRADDETAVAARVVSTVRDPRISESSGLAVSAVHDDLAYTINDSGNADVVYAVRISTGEVVGTTTVSGTPWVDTEAMTLHDGKLWIGDVGDNSAQRRDTAIYAIDEPGPGTHAARSTRYPVGYSDGPHDVESLAVDGDGRFLLVTKDLLSGQVLRFPDALSTQRTNVPEPVGDPTLLMATDASTSPDGRYVVVRNYIAAAVLNASDLSLVRTEALPEQPQGETLAFEPSGGSYLIGSEGSPWQLQRVGFSAERAGAAVPSATPTPTATTPAAATTPSAPAPTELGRPWFAVAVGGLAVLLLAAFGVWITRRDDD
>NZ_CP011502.1|WP_067861789.1|2790786_2791008_+|DUF2530-domain-containing-protein
MDLDGVRTMTVGTILWGVVAVALVPFLGTLEEQGRTWWLWTAIAGFGLGLLGIEYCRLRRNALRHQPGRRRDG
>NZ_CP011502.1|WP_067859598.1|2791026_2791761_-|DUF3027-domain-containing-protein
MRTHPALGAAHDVARAALLEATDESAVGEHLRVVDDGERLATHLFACTGPGYRGWTWAVSLSAGVEDDAVTVNDVVLLPGDDAVVAPAWTPYRDRIKPGDLSPGDVLPPEEDDARLVPAWSAGDHLDTVDRAFAREVGLGRAWVLSLEGRDLAAQRWNDGEQGPDNPMTKQAPGTCDSCGFLVSLAGPLSDRFGVCANGSANDDGRVVALDHGCGAHSGARLSRSAGPQKLPPPVWDTVDVDEL
>NZ_CP011502.1|WP_083516445.1|2791864_2793388_+|MFS-transporter
MAPTSDGDDRTPGPDWPGPSGSRAAGTAGDRDTLDDLGPDQEAPTGADTGTPPPRRGAKVASGLRRTGRTVARGGAGAVAGARRFTHAGGAGESGLSRLLELHAFNTAGDAAVAVSLAGTLFFTVPTEQASGQVALFLVLTMLPFAFVAPLIGPFLDRFRRGRRWAIGGTLAIRAFCCWVLAGAVAEESPAFYLAALGCLVASKAYGVTRASAVPRLLPEEFTLVKANSRISLTGTAAAAVSAPLAVGAAAIGAEWSLRYAFVLFVVGTVLAILLPARVDSSEGEEQVDLSDLSGRPAKRGITVSRHVVDALRSNAGLRLITGFLTIFMAFTLREPPASLGWTGNATILMGLVIGAAGAGNTLGVVIGSWTRSRSPHRVVLVVLLVDIVALVVAAAFFRWPVAALLGLTVGLCQSLGKLSLDALIQRDIGEEVRTSMFARSETLLQLSWVIGGLIGIGLFTLDADVALAMFVTAGVVVAWGVFVLRQAHLARRLPTEPVGPVPPPAP
>NZ_CP011502.1|WP_083516446.1|2793390_2794236_-|dioxygenase
MTTIPSGPRVEHRLSDLEQRLRPSERMPVLFVGHGNPMHAIRENHYTHTWTVEGQRLPEPQAIVVVSAHWLTPGRTHVTDAPRNRVIYDFGGFPEELSRVQYDTVGDHEVARVLAHRLAEYEAALDSQWGLDHGTWSVLKYLAPAPQVPVLQISIDDTLPLPRLHELYGRLRRLRDQGVLFIGSGNIVHALGRARWEPEAPAWDWAEQFDADTAAALTDRRLDQLLDPYGTWREARIAVPTDEHYRPMVAALSLLHPEEEVRFFNASIDMGSIGMRSFVTV
>NZ_CP011502.1|WP_067859601.1|2794315_2794711_-|cold-shock-protein
MPTGKVKWYDTEKGFGFISSDEGGDVYVRSDALPADVTALKSGTRVEFGVAQGRRGDQALQVRVIEGSAPVSRTQARARRKKPEEMVTIVEDLIRLLDGLGEGYRHGRHPDARSAKPVAQLLRALATELDG
>NZ_CP011502.1|WP_067859604.1|2794756_2795758_-|YihY/virulence-factor-BrkB-family-protein
MSAVDKVDRFQRRHRFVGLPLAVIYKYFDDQGPYLAAIVTYYAFVAVFPLLLISTSILGFVLQGDPQLRESLLNTALSQFPIVGDQLGSEQGLQGSTTAIVVGSIAALYGAMGLGQAAQNAANIAWSVPRNSRANPFLMRLRSLIFLAIAGIGILVLAVATSVLANPDAFGGLVGPATGWIVRGTGFVLTAAIFVGLFRLVSAGRAHTRSVLPGAIFAAVGWQLLQLAGNSYVTRVINRASQTVNQTFALVLGLLAFIFVAAVLVVMALELNVVLRRHLYPRALLTPFTDNVELTEADERAYTAYAKAQRHKGFQVIEARFEKDEDEPPGTTP
>NZ_CP011502.1|WP_067861797.1|2795754_2796132_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MTYAPKPDGRPDPGEIVWTWVPYEDDPAQGKDRPVLVVGRDGARLVGLMLTSKDHDRDAAQEARDGRFWLDIGSGPWDAQGRPSEVRVNRLIDVDPDAVRREGAVLDEPRFAAVLAAAAEHLELA

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Crispr_ID: NZ_CP011502_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_14

2978166-2978291

Orphan

Consensus_repeat	Method
CCCAGTAGCGCGTGTCACCTACCGCTCACCCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011502_14

>merge|NZ_CP011502|14|2978166-2978291|CRISPRCasFinder
CCCAGTAGCGCGTGTCACCTACCGCTCACCCACATTCCGCATCCCACCTACCGCGCCAGAGGGTGCAGCGGTAGGTAGCACGCGTCATCAGGCCCCAGTAGCGCGTGTCACCTACCGCTCACCCAC

>NZ_CP011502|14|14|2978166-2978291|CRISPRCasFinder
CCCAGTAGCGCGTGTCACCTACCGCTCACCCAC	ATTCCGCATCCCACCTACCGCGCCAGAGGGTGCAGCGGTAGGTAGCACGCGTCATCAGGC
CCCAGTAGCGCGTGTCACCTACCGCTCACCCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067860077.1\|2971154_2971784_-\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	unknown	unknown	gnl\|CDD\|225687
NZ_CP011502.1\|WP_067860089.1\|2975774_2976701_-\|asparaginase	unknown	unknown	gnl\|CDD\|377601
NZ_CP011502.1\|WP_067860083.1\|2974126_2974390_-\|DUF2516-family-protein	unknown	unknown	gnl\|CDD\|378483
NZ_CP011502.1\|WP_067860071.1\|2968307_2968937_-\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NZ_CP011502.1\|WP_067860073.1\|2968933_2969665_-\|endonuclease-III	unknown	unknown	gnl\|CDD\|223255
NZ_CP011502.1\|WP_067860103.1\|2985616_2986732_+\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP011502.1\|WP_067860075.1\|2969766_2970444_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NZ_CP011502.1\|WP_144433803.1\|2986765_2988550_-\|DUF4012-domain-containing-protein	unknown	unknown	gnl\|CDD\|379067
NZ_CP011502.1\|WP_067860081.1\|2972253_2973942_-\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_CP011502.1\|WP_083516468.1\|2985046_2985487_+\|D-tyrosyl-tRNA(Tyr)-deacylase	unknown	unknown	gnl\|CDD\|235383
NZ_CP011502.1\|WP_067860087.1\|2975258_2975687_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP011502.1\|WP_083516467.1\|2979528_2981397_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|236941
NZ_CP011502.1\|WP_067860099.1\|2982931_2983477_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319972
NZ_CP011502.1\|WP_067861828.1\|2983478_2984438_-\|folate-binding-protein-YgfZ	unknown	unknown	gnl\|CDD\|223431
NZ_CP011502.1\|WP_067860094.1\|2978317_2979502_-\|mannose-6-phosphate-isomerase,-class-I	unknown	unknown	gnl\|CDD\|380414
NZ_CP011502.1\|WP_067860092.1\|2976839_2977925_+\|mannose-1-phosphate-guanylyltransferase	unknown	unknown	gnl\|CDD\|133003
NZ_CP011502.1\|WP_067860079.1\|2971876_2972185_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067861830.1\|2984496_2985009_-\|FABP-family-protein	unknown	unknown	gnl\|CDD\|378046
NZ_CP011502.1\|WP_067860106.1\|2988557_2989304_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|380149
NZ_CP011502.1\|WP_158509215.1\|2981595_2982909_+\|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl\|CDD\|349772

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067860077.1\|2971154_2971784_-\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	gnl\|CDD\|225687	COG3145, AlkB, Alkylated DNA repair protein [DNA replication, recombination, and repair].	2.45085e-27
NZ_CP011502.1\|WP_067860089.1\|2975774_2976701_-\|asparaginase	gnl\|CDD\|377601	pfam06089, Asparaginase_II, L-asparaginase II. This family consists of several bacterial L-asparaginase II proteins. L-asparaginase (EC:3.5.1.1) catalyzes the hydrolysis of L-asparagine to L-aspartate and ammonium. Rhizobium etli possesses two asparaginases: asparaginase I, which is thermostable and constitutive, and asparaginase II, which is thermolabile, induced by asparagine and repressed by the carbon source.	3.55766e-128
NZ_CP011502.1\|WP_067860083.1\|2974126_2974390_-\|DUF2516-family-protein	gnl\|CDD\|378483	pfam10724, DUF2516, Protein of unknown function (DUF2516). This family is conserved in Actinobacteria. The function is not known.	7.20546e-15
NZ_CP011502.1\|WP_067860071.1\|2968307_2968937_-\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	2.11721e-32
NZ_CP011502.1\|WP_067860073.1\|2968933_2969665_-\|endonuclease-III	gnl\|CDD\|223255	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair].	2.65178e-95
NZ_CP011502.1\|WP_067860103.1\|2985616_2986732_+\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	1.08695e-52
NZ_CP011502.1\|WP_067860075.1\|2969766_2970444_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	4.62141e-52
NZ_CP011502.1\|WP_144433803.1\|2986765_2988550_-\|DUF4012-domain-containing-protein	gnl\|CDD\|379067	pfam13196, DUF4012, Protein of unknown function (DUF4012). This is a family of uncharacterized proteins found in archaea and bacteria.	7.931e-43
NZ_CP011502.1\|WP_067860081.1\|2972253_2973942_-\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	0
NZ_CP011502.1\|WP_083516468.1\|2985046_2985487_+\|D-tyrosyl-tRNA(Tyr)-deacylase	gnl\|CDD\|235383	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional.	1.06435e-81
NZ_CP011502.1\|WP_067860087.1\|2975258_2975687_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	5.19582e-14
NZ_CP011502.1\|WP_083516467.1\|2979528_2981397_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|236941	PRK11634, PRK11634, ATP-dependent RNA helicase DeaD; Provisional.	0
NZ_CP011502.1\|WP_067860099.1\|2982931_2983477_-\|hypothetical-protein	gnl\|CDD\|319972	cd16344, LMWPAP, low molecular weight protein arginine phosphatase. Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.	3.35055e-31
NZ_CP011502.1\|WP_067861828.1\|2983478_2984438_-\|folate-binding-protein-YgfZ	gnl\|CDD\|223431	COG0354, COG0354, Predicted aminomethyltransferase related to GcvT [General function prediction only].	1.60832e-58
NZ_CP011502.1\|WP_067860094.1\|2978317_2979502_-\|mannose-6-phosphate-isomerase,-class-I	gnl\|CDD\|380414	cd07011, cupin_PMI_type_I_N, type I phosphomannose isomerase in eukaryotes and bacteria, N-terminal cupin domain. This subfamily contains type I phosphomannose isomerase (PMI; E.C. 5.3.1.8; also known as mannose-6-phosphate isomerase) found in eukaryotes and some bacteria such as Salmonella enterica. PMI catalyzes the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P), the first committed step in the synthesis of mannosylated glycoproteins. The active site, located within the N-terminal jelly roll-like beta-barrel cupin fold, contains a single essential zinc atom and forms a deep, open cavity large enough to contain M6P or F6P. PMI type I also has a C-terminal beta-barrel fold which has diverged considerably from the N-terminal domain and is not included here. This subfamily contains an alpha helical domain that is found in eukaryotic and some prokaryotic PMIs but is not present in their archaeal counterparts. F6P is a substrate for glycolysis and gluconeogenesis, while M6P is a substrate for production of activated mannose donor guanosine 5'-diphosphate D-mannose, an important precursor of mannosylated biomolecules such as glycoproteins, bacterial exopolysaccharides and fungal cell wall components. PMI is also essential for survival, virulence and possibly pathogenicity of some bacteria and protozoan parasites, as well as for cell wall integrity of certain yeasts. Thus, PMI is a potential target against fungal infections causing serious illness or death.	2.13553e-98
NZ_CP011502.1\|WP_067860092.1\|2976839_2977925_+\|mannose-1-phosphate-guanylyltransferase	gnl\|CDD\|133003	cd02509, GDP-M1P_Guanylyltransferase, GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose. GDP-mannose-1-phosphate guanylyltransferase, also called GDP-mannose pyrophosphorylase (GDP-MP), catalyzes the formation of GDP-Mannose from mannose-1-phosphate and GTP. Mannose is a key monosaccharide for glycosylation of proteins and lipids. GDP-Mannose is the activated donor for mannosylation of various biomolecules. This enzyme is known to be bifunctional, as both mannose-6-phosphate isomerase and mannose-1-phosphate guanylyltransferase. This CD covers the N-terminal GDP-mannose-1-phosphate guanylyltransferase domain, whereas the isomerase function is located at the C-terminal half. GDP-MP is a member of the nucleotidyltransferase family of enzymes.	1.08816e-110
NZ_CP011502.1\|WP_067861830.1\|2984496_2985009_-\|FABP-family-protein	gnl\|CDD\|378046	pfam08768, DUF1794, Domain of unknown function (DUF1794). This domain forms a beta barrel structure but the function is unknown. The GO annotation for this protein indicates that the protein has a function in nematode larval development and has a positive regulation on growth rate.	4.30867e-58
NZ_CP011502.1\|WP_067860106.1\|2988557_2989304_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|380149	NF012181, MSCRAMM_SdrD, MSCRAMM family adhesin SdrD. Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.	6.62399e-07
NZ_CP011502.1\|WP_158509215.1\|2981595_2982909_+\|polysaccharide-biosynthesis-tyrosine-autokinase	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	3.68786e-67

>NZ_CP011502.1|WP_067860092.1|2976839_2977925_+|mannose-1-phosphate-guanylyltransferase
MSTAPSDLDDLHVIIPAGGAGTRLWPLSRAGRPKFLLDLTGSGRTLLQQTWDRVTKLVPPERVHVVTGPRHADAVRAQLPGLTSVFVEPSPRDSMPAIGLATAVVLARHPEAVVASFAADHVITGEDRFADAVAQAVRTARTGAVTTIGISPRSPSTAFGYVESGAPLAVDGAPSARTVVRFVEKPDEETARAYLRAGTFSWNAGMFVTRADVLLGHLARLQPTLHAGLQRIAAAWDGPDAQTVLEAVWPSLTRIAIDHAVAEPVSLTGGIATVPGRFGWDDIGDFAALHELGVSGDTGVVWVDADGLVRTTGGVTVAVVGIPGAVVVQTDDALLVTTVEHAQRVKEVPAALAASGRTDLV
>NZ_CP011502.1|WP_067860089.1|2975774_2976701_-|asparaginase
MDVVAEVVRSGLVESRHRGMAVRVDPDGQTVWSIGDPGTVVFPRSTNKPFQAAGLVREGLDLEPRLLALAAASHSAEPFHLEGVREILARGDLDESALQTPPSYPVDPHEHAAVLRAGEGRLPIRMDCSGKHAAMLLTCVQRGWSTHDYLDPDHPVQRAITATFTELVGPPDVVGVDGCGAPLLATSLERLARGVGRLMRAEPGSAERRVADAMVAHPEQVSGTRRPDLALARAVPGSLVKSGAESVVVAGLADGSALAVKIEDGGERPLFVVLHRALELAGVDADLLRERPVVLGGGRPVGEVRPVL
>NZ_CP011502.1|WP_067860087.1|2975258_2975687_-|helix-turn-helix-transcriptional-regulator
MAKLHVGGAVETLGDYLREQRRQAQMSLRQLAEKSEVSNPYLSQIERGVRRPSAEVLQQIAKALRISAESLYVRAGLIDVDESGARMVEDAIALDPRLTERQKTALLDIYRSFVGADVATDETLAETVTEANSDTSSEETPP
>NZ_CP011502.1|WP_067860083.1|2974126_2974390_-|DUF2516-family-protein
MFEVQSSLMLLLSLVLFAVKAFALVDCVLRDAGRFSVADSLPKNTWLVILGLAVVAHAVFWAPLSLLNLAGTVAALVYLAQLRGSHV
>NZ_CP011502.1|WP_067860081.1|2972253_2973942_-|BCCT-family-transporter
MSTRTEHEHAPQARWRTRIDPVVFGVTGAVAIAFVVWGLVSTDGLKAASDASRSWVIVNTGWFFVLVASFFVLFVLWLAASKYGRVPLGEDDEKPEFRTVSWIAMMFSAGMGIGLMFWGVAEPLSHFASPPPGTGEPQSEEALQSAMASTMFHWGLHPWAIYAVVGIAIAYGTFRKGRSQLISSAFRPLIGRRAEGPAGRVIDILAIFATLFGSAASLGLGALQIGAGLQFNGWIDQPGKIALVAIIAVLTVLFILSAVSGIERGIQWLSNTNMVLALALAVFVFVVGPTLFILNMLPTTLGDYASQMTEMASRTAASGDQAMEAWLSSWTIFYWAWWVSWTPFVGMFIARISRGRTIREFVTGVLLVPTLVSLVWFAVFGGSAIFEQRASGGLIGSDGSVASDFALFQLLEKYPAAGITSVLVMVLVGIFFVSGADAASIVMGTLSERGATEPSRVSVIFWGALTGAVAAIMLVIGGSDALTGLQNITIVASVPFVFVMVALCVSLWKDLQSDPVVVRHRLGQEAVEGAVVVGVEEHDGDFALVVEPTDSSAEPASDEKQQ
>NZ_CP011502.1|WP_067860079.1|2971876_2972185_+|hypothetical-protein
MSAWDALLDRVDEIVDTRAPVDAEVQSELTELLLGAMRDGTADRELDPGEAGLWLAALLRTHADVQDAGERRADDALSTLRVIITRWLHPGRLDQAPPTFGA
>NZ_CP011502.1|WP_067860077.1|2971154_2971784_-|alpha-ketoglutarate-dependent-dioxygenase-AlkB
MWFQGSLLDVGDEAVVGSLGAAVQRRELTHGAWVDVRPGWVQGADPLFLSLQTEVRWRAERRQMYDETVDVPRLLAHFGAADTLPHPALDAARAALNAHYADELGEEFVTAGLCYYRDGRDSVAWHGDRIGRGRAEDTMVAILSLGAPRRLSLRPVDHGAGDTIGFVVGHGDLLVMGGSCQRTWEHAVLKTAKPVGPRISVQFRPRGVL
>NZ_CP011502.1|WP_067860075.1|2969766_2970444_+|Crp/Fnr-family-transcriptional-regulator
MNDDVLRQAPLFSGLDDDAAGALEASMSPLSLKRGEVLFNEGDDGNQLYVVTEGKIKLGRTAPDGRENLLAILGPGQMFGELSFFDPGPRSATATSVTDVTVQSLSHEALTPVLSSHAEVALALLNQLAGRLRRTNEVVGDLVFSDVPGRVAKALLDLASRFGRKAEDGVHVNHDLTQEELAQLVGASRETVNKALADFASRGWLRLEPRSVVILDLERLQRRAR
>NZ_CP011502.1|WP_067860073.1|2968933_2969665_-|endonuclease-III
MPPAAPEAPVKPPTSLVRRARKIHRVLAETYPEAGCELDFRTPFELLVATVLSAQTTDRRVNAVTPALFAAYPDAAALAAADRTAVEEIIRSTGFYRAKTDSVLGLSAALVERYDGEVPARLRDLVTLPGVGRKTANVVLGNAFDVPGLTVDTHFARLVRRFEWVDDDVAKDPVKTEHAVGALFPRRDWTMLSHRLIWHGRRRCHARKPACGACPVAHWCPAYGTGPTDPVEAARLVTTQGRA
>NZ_CP011502.1|WP_067860071.1|2968307_2968937_-|TlpA-family-protein-disulfide-reductase
MRRLAVAVAVLALLLAGCSDVDTSSGKPTFGGGSLDGGDPQSASVRSGVQDAGVRPCSDLPLADAGAEGDGALPALELPCLGGDGSVDLSRLRGPAVVNFWASNCKPCREELPLLARLDRDTGDRLTVVGLDVRDADPDAAVALARRSRVTYPQLSDPTFRTRGAFRVLGLPQTVFVDAQGRMVATERVPYTSYADLTGAVRRHLEVQP
>NZ_CP011502.1|WP_067860094.1|2978317_2979502_-|mannose-6-phosphate-isomerase,-class-I
MRRLDNPDRDYDWGSPDAIPRFLGRTPDGAPVAEIWMGTHPLNPSTVQGADGPVSLREVAGELPFMLKILAADRPLSIQVHPNAVLAQEGFEAEEAAGVPLDAPHRVYKDPHPKPEMVYALTAFDTLVGFRPTAEILRVLAAIDVPRVHQLVENLRRQPGFLGIVRIVEDLLTDRPSPEEVAAVVAACRAGVDRGIDIKRAYATAVLVDEHHPGDVGVVMSLLLNRLTLQPGEAAYLGAGIIHAHLSGLCVEVMVSSDNVLRGGLTGKHLDPQGLVRCLDRGMSRLARVDADQFGFSTDVYSPGLHEFALSVTQCSSAEPDGARLPDDGRRIVVCLGGEVEVVNEAGEREHLARGEAVFADESDGVLHAVGTGEVAQAYTPAPDLPPTELTDLV
>NZ_CP011502.1|WP_083516467.1|2979528_2981397_-|DEAD/DEAH-box-helicase
MTDDRPASDLSDQTPEQEASTVPEAAAPGARFAALGLGDELVEVLGGLGYEAPTPIQEAAVPALLAGRDVVGLAQTGTGKTAAFALPILEKIDPDRASTQALVLAPTRELALQVCEAMTSYTPRSRRIRVLPVYGGQGYGAQLAGLERGAHVVVGTPGRVMDHLDRGSLDLSGLDHLVLDEADEMLAMGFAEDVERILADTPEYKQVALFSATMPPAIRRLAKRYLHDPADIATPQARSSTSTVRQRWIPVSHHAKLDALTRLLEVESGDAMIIFVRTKSATEELAERLRSRGFSAAAINGDLVQAQRERTVTALKNGSLDILVATDVAARGLDVDRITHVVNYDIPHDPEAYVHRVGRTGRAGRSGEAILFVTPRERRLLSAIEKVSGRPVEETGVPSVDEVNARRTAKFAQAITDSMGSAQFHAFRGLVEDYVREHDVEMLDVAAALAVMSTDDKEFFLRPDPPKKERRERPERQDRPARDAGDRPARPSKDGWAPYRIAVGKRHKVTPSMIVGALANEGGLRRADFGKITLGIDHAVVELPQDLPPAVFEALADTRISGRRIDLQADRGARGGRSSRDDRPTAHRKGSGAPGGKGKGGQRGSWSKDGESPRKPRHPKGH
>NZ_CP011502.1|WP_158509215.1|2981595_2982909_+|polysaccharide-biosynthesis-tyrosine-autokinase
MVLLGLLGALAGQLVVSGLTPRYEASAEVLVSSPPASVDGSARAVTARTVESYGRLLSQPYLLDRAARALDESSLPADSVRSGVVGDSDVLRVTVRDDSLDVARERAGAIAEAFTAWLEDSQQALRPNQQVTGLVIDPGTGSTGPVSPRRWPYLLGGLLVGLLLGLGVARWRQLADRGVASADELEATTEAPLLGAIAYDRSVQDAPLLTSLSPQHPRAESIRILRTNLQFVDVDHDRTVITVTSAVEAEGKTSTACNLAIALAQSGLRVALVEGDLRRPQLAEQFGLESTVGLTTVLVGRVELDEAMQETEIPGLDVLTSGARPPNPAEIVQTGAMEQLVADLRRAYDIVLIDAPPLLPVTDATILALLSDGALLVVRHGRTGHDQVRAAVERLQTVGATLFGTVLSMSPRRAAGRFGYGYEYATQSSRRRPRRGR
>NZ_CP011502.1|WP_067860099.1|2982931_2983477_-|hypothetical-protein
MGARPEPARWSILTVCTANVCRSPLMELLLRERLDPARFEIASAGVMGWRDAPVDSMVRLELARLGVDGSDFRSRPLHPAHVKAADVVLTATKEHRASVLELDPGALRKTFTLLELAALVEDRTADSLPELVADAARRRSTAPSLLDVPDPFRRAPEVHRSTADLIDDATERLARTFGTLA
>NZ_CP011502.1|WP_067861828.1|2983478_2984438_-|folate-binding-protein-YgfZ
MLGLDGAVEADAPDSGVAAHYGELTVEQRRLERGEGFVDLSHRDVLTVTGPDRLTWLHSLTTQHLESLPPGVRTEVLVLTPQGRIEHAFEGVDDGTTFWAHTEPGAGAALVTFLDRMRFMMRVEVADVSDAHAVLGRVEPGSDGAPGRAVWAIEPRADVASWPERHGRPAGTWAWEALRIASGTPRLGLDTDDRTIPNEVGLLERAVHLDKGCYRGQETVARVHNLGRPPRRLTLLHLDGSADRLPAPGSPVERADAPGQAVGVLGSRGLHHELGPIGLALLKRSVPTDATLVVDGVAAAQELVVDPEVGLHVRPRSGG
>NZ_CP011502.1|WP_067861830.1|2984496_2985009_-|FABP-family-protein
MAFEIPADLHPDVAPLAWLLGTWHGNGRGEYPTIEPYAFEQDVVFAHDTRPFLHYFSRSWTTDEEGNRTGPGDLETGFLRPAGLVEGGKGINVELVLAHPTGYAEVWYGVAEGPRITLATDIVARTATAVEYTAGQRMYGLVEGALMYAVDKAAEGQSMQSHLWGKLARV
>NZ_CP011502.1|WP_083516468.1|2985046_2985487_+|D-tyrosyl-tRNA(Tyr)-deacylase
MRAVVQRVTQASVVVEGEVVGSVGGGEEDGGHLLVLLGVTHDDTVQKAESLARKVHGLRVLREERSVADTGGSVLVVSQFTLYGDARKGRRPSWTAAAPGAVAEPLYEEFCAALRALGTDVPTGRFGADMQVASVNDGPVTILLEL
>NZ_CP011502.1|WP_067860103.1|2985616_2986732_+|LCP-family-protein
MSRRLKRERRAVAGKRRMGGTPWHRRHRRLLVGVVGVLVVVLGTASGYAYYLNSQLDNVGRVDTQLKEKDRPDPDRGRALNILLLGSDKGKEEPGARDTTLAEDAAASRWPAGKYRSDTLMIAHITSDRRKVYLVSIPRDTFTDIHDQTGAVRSKQKINDAFSEYGPDGAISTVENLTNLRMRHLAIIDWDGFESLSSAVGGVPVFIPRAFYDPKQEVQWQAGQQTLEGKKALAYVRTRYGLVRGDFDRIARQQNFLRSLMKKMLARDTLSNPIKLTRTLTAVTKNLTVDADWDPGDMRALALSLRGVRSDDVTFLTAPVAGTELDPTYGDVVVLDQAKCAELFDALRNDRMDAYLRKYPDDRLADERQIG
>NZ_CP011502.1|WP_144433803.1|2986765_2988550_-|DUF4012-domain-containing-protein
MRPPRRFLPERWDRAGWARLVLSVVGGVVLVCGVVLAWQGVRAAILLQRASDASQVLLAQVAQGDADGARRTAEVLEDAARRSHDSTDGPLWAVASWLPVVGDDVDAVRVVSREVDRVATRAVPTVVDVTAQVGLDAFSPRDGRVDIANLESVAPRLGAPRRALDEAARNVGDIRPEDVVGRLQVPVRRLQDVLTGAASAARVADTAATLLPDMLGAQERRRYLLLIQNNAEVRSLGGIPGSWAVIEADRGRVRMTEQGSAIDVPPVDDPRLAVPASQYGAVPVSAAEDLRNTTSVPDFPEAARFAGSLVGEATDTRFDGVVSVDPVTLGYLLQGLGPVTLGDGTRLTSENAVDELLNGVYRRYTTDPLAQDAVFEDAARSIFDAFVGGRGATQPVLEALVRAAVDNRVMVWSADRSEQRRIRTTGVSGVLSQDADRARVGVFVDDSKGSKLQYYLETSHTLTSSRCVDDRSQELTLRTRLSSVVPRSGLPVSITGFRLPGLSATDQRLSVRVVAPAGGVLQQVRLGDVDRQPVGGRLGDRRVTVVPLTLRAGESVDLTVTMRTGDGQTDDPVLTSTPGIRAEPNDVRVRSACG
>NZ_CP011502.1|WP_067860106.1|2988557_2989304_-|LPXTG-cell-wall-anchor-domain-containing-protein
MKKHLAALVASVVAAVGLVALPSATLAPAQGATLPYPVLVCDIQVSKTRVAPGETFTATVTADVPTTITATYEGQTRSASNTKKLVATFTAPQVTRSTSTTVRAICGDKAGSGAEVVVAPSGGSNGDGGSQGDSDADGGSQGDADADGGSQGDADVSADGGSQSDADADGGSQGDADVNADGLGSQGDADVNAGGAGTDGVADADAGTEDRNGILPGTGGTDFWLLVLGALLVLAGVGAVVARRRRDG

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Crispr_ID: NZ_CP011502_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_15

3015773-3015865

Orphan

Consensus_repeat	Method
TCCGGTGGAGGATCCACCGCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011502_15

>merge|NZ_CP011502|15|3015773-3015865|CRISPRCasFinder
TCCGGTGGAGGATCCACCGCCCGCGCGCCCACGCCCCGAGCGGTGCGAGATCCACCCGAAGAACCGCTCCTCCGGTGGACGATCCACCGCCCG

>NZ_CP011502|15|15|3015773-3015865|CRISPRCasFinder
TCCGGTGGAGGATCCACCGCCCG	CGCGCCCACGCCCCGAGCGGTGCGAGATCCACCCGAAGAACCGCTCC
TCCGGTGGACGATCCACCGCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067860170.1\|3024392_3025643_-\|MSMEG_0569-family-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274942
NZ_CP011502.1\|WP_067860163.1\|3018772_3019573_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NZ_CP011502.1\|WP_067861842.1\|3023547_3024393_-\|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|143587
NZ_CP011502.1\|WP_158509216.1\|3021071_3022460_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341252
NZ_CP011502.1\|WP_067860145.1\|3010734_3010953_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_083516469.1\|3019666_3020419_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|236173
NZ_CP011502.1\|WP_144433804.1\|3013825_3014164_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223377
NZ_CP011502.1\|WP_169795973.1\|3010239_3010389_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067860139.1\|3007450_3008230_+\|phosphate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|184587
NZ_CP011502.1\|WP_067860157.1\|3015880_3016990_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|234821
NZ_CP011502.1\|WP_067860149.1\|3012023_3012386_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067860159.1\|3016986_3018000_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270276
NZ_CP011502.1\|WP_067860161.1\|3017996_3018788_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
NZ_CP011502.1\|WP_067860141.1\|3008502_3009528_-\|inorganic-phosphate-transporter	unknown	unknown	gnl\|CDD\|376541
NZ_CP011502.1\|WP_067860151.1\|3012469_3013642_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|367155
NZ_CP011502.1\|WP_067860143.1\|3009531_3010149_-\|DUF47-domain-containing-protein	unknown	unknown	gnl\|CDD\|224310
NZ_CP011502.1\|WP_067860147.1\|3011095_3011647_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067860168.1\|3022456_3023551_-\|MSMEG_0565-family-glycosyltransferase	unknown	unknown	gnl\|CDD\|274943
NZ_CP011502.1\|WP_067860165.1\|3020507_3021065_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380054
NZ_CP011502.1\|WP_067860155.1\|3014684_3015347_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067860170.1\|3024392_3025643_-\|MSMEG_0569-family-flavin-dependent-oxidoreductase	gnl\|CDD\|274942	TIGR04046, predicted_flavoprotein_involved_in_K+_transport, flavin-dependent oxidoreductase, MSMEG_0569 family. Members of this protein family belong to a conserved seven-gene biosynthetic cluster found sparsely in Cyanobacteria, Proteobacteria, and Actinobacteria. Distant homologies to characterized proteins suggest that members are enzymes dependent on a flavinoid cofactor.	0
NZ_CP011502.1\|WP_067861842.1\|3023547_3024393_-\|carbon-nitrogen-hydrolase-family-protein	gnl\|CDD\|143587	cd07197, nitrilase, Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes. This superfamily (also known as the C-N hydrolase superfamily) contains hydrolases that break carbon-nitrogen bonds; it includes nitrilases, cyanide dihydratases, aliphatic amidases, N-terminal amidases, beta-ureidopropionases, biotinidases, pantotheinase, N-carbamyl-D-amino acid amidohydrolases, the glutaminase domain of glutamine-dependent NAD+ synthetase, apolipoprotein N-acyltransferases, and N-carbamoylputrescine amidohydrolases, among others. These enzymes depend on a Glu-Lys-Cys catalytic triad, and work through a thiol acylenzyme intermediate. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. These oligomers include dimers, tetramers, hexamers, octamers, tetradecamers, octadecamers, as well as variable length helical arrangements and homo-oligomeric spirals. These proteins have roles in vitamin and co-enzyme metabolism, in detoxifying small molecules, in the synthesis of signaling molecules, and in the post-translational modification of proteins. They are used industrially, as biocatalysts in the fine chemical and pharmaceutical industry, in cyanide remediation, and in the treatment of toxic effluent. This superfamily has been classified previously in the literature, based on global and structure-based sequence analysis, into thirteen different enzyme classes (referred to as 1-13). This hierarchy includes those thirteen classes and a few additional subfamilies. A putative distant relative, the plasmid-borne TraB family, has not been included in the hierarchy.	2.56248e-64
NZ_CP011502.1\|WP_158509216.1\|3021071_3022460_-\|AMP-binding-protein	gnl\|CDD\|341252	cd05929, BACL_like, Bacterial Bile acid CoA ligases and similar proteins. Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.	1.96066e-113
NZ_CP011502.1\|WP_144433804.1\|3013825_3014164_-\|hypothetical-protein	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	4.17824e-25
NZ_CP011502.1\|WP_083516469.1\|3019666_3020419_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|236173	PRK08177, PRK08177, SDR family oxidoreductase.	1.00709e-56
NZ_CP011502.1\|WP_067860163.1\|3018772_3019573_-\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	2.27048e-75
NZ_CP011502.1\|WP_067860139.1\|3007450_3008230_+\|phosphate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|184587	PRK14241, PRK14241, phosphate transporter ATP-binding protein; Provisional.	0
NZ_CP011502.1\|WP_067860157.1\|3015880_3016990_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|234821	PRK00719, PRK00719, alkanesulfonate monooxygenase; Provisional.	1.37241e-149
NZ_CP011502.1\|WP_067860159.1\|3016986_3018000_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270276	cd13558, PBP2_SsuA_like_2, Putative substrate binding domain of sulfonate binding protein, the type 2 periplasmic binding protein fold. This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.57658e-95
NZ_CP011502.1\|WP_067860161.1\|3017996_3018788_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	4.95567e-98
NZ_CP011502.1\|WP_067860141.1\|3008502_3009528_-\|inorganic-phosphate-transporter	gnl\|CDD\|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	9.22512e-96
NZ_CP011502.1\|WP_067860151.1\|3012469_3013642_-\|HNH-endonuclease	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	4.96359e-24
NZ_CP011502.1\|WP_067860143.1\|3009531_3010149_-\|DUF47-domain-containing-protein	gnl\|CDD\|224310	COG1392, COG1392, Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism].	3.97829e-32
NZ_CP011502.1\|WP_067860168.1\|3022456_3023551_-\|MSMEG_0565-family-glycosyltransferase	gnl\|CDD\|274943	TIGR04047, MSMEG_0565_glyc, glycosyltransferase, MSMEG_0565 family. A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity].	1.89602e-135
NZ_CP011502.1\|WP_067860165.1\|3020507_3021065_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380054	pfam17920, TetR_C_16, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins found in Actinobacteria. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.	2.47555e-11

>NZ_CP011502.1|WP_067860155.1|3014684_3015347_-|hypothetical-protein
MQEAPVEEPPVETVAEPTVPLEPTPAPTALASDGAGSTEATSSDATSSGGTSVARVLLVLGVIAALVAGGYFGISALTGDDDSGSPVAGTSASKDSDDKGGDKGGDEASGSGDSDQFCSVMKDLRDSSLSSLDNLNSEGGTPDLDALRQQLDETAAKYEALRKAAPAEIADDVKVLADLMSSSASASSSGGTSPFADFSSKEYLDASTKVSQYYYTHCST
>NZ_CP011502.1|WP_144433804.1|3013825_3014164_-|hypothetical-protein
MLYTGIKSYVLDMSQALDMELKPHGVHVTALCPGFTRSEFHATMGSAEAANRLPALLWQEADAVAREGWAAVESGKPVCVPGRVNKVLSHAMRPVPFRLQYLMGRSLNPFKH
>NZ_CP011502.1|WP_067860151.1|3012469_3013642_-|HNH-endonuclease
MSSTALAARLEAVAAELRAYPTSTDALRLLQGLSNAIDAEKVALVAEIDEHRDFEAEGCSSLKNWLRDQLHLDGKQAGQLVRSGRTLRDMPDLESLAVEGAVSLDHVDAFGYAARHIDPMVVEHSMDWMLRLAERAEPVQIRKAVKKLRATAHPDDLDEAWIKGMDRHDLKVSVVGDGVAVTGFLPFDTGTKLKTVLQSLSAPTCAEDDRPVSIRRVTALDALLSSVLASGLPQDKGVRPHITLTADLTDLAQDASTATGELAGFGTIGPTQLQQMLCDSDITPILTAGKHTVLDVGRTHRLATPHQRKAVVNRQGGTCAGPGCHGPVVHVHHIEYWSDGGPTDLANLIGLCPRCHAAVHQGFFTIDPDTHQTHRTLRTRRTNARRTRAG
>NZ_CP011502.1|WP_067860149.1|3012023_3012386_+|hypothetical-protein
MEPGSLADAAASGDLADLLLPDGSQPYTHHLRIEHFAYTFVPVPTLTLVLPPSSDDGPSTRVRFVDAVVTDWTTEASYSPDDPNDELCELRWDGWRTFLLDFLSFKIIVRAGRLDVEVIE
>NZ_CP011502.1|WP_067860147.1|3011095_3011647_-|hypothetical-protein
MDRLGVRTSRVALLDGDQRSRQDGSATAVLEWTINGVPLRKIVDNPTSTTPLYAAADEDQRRELLLRLRGDRTDLPTFVPRFERTRLDRLLGRRGTPWAPFGPAFEDGRVVLLECPCGDLDCGALTTEVVVADDAVEWREIGWQVTYEPFAGYNAEVWSARFDRSQYVAVIDDVLAMDWSQVQ
>NZ_CP011502.1|WP_067860145.1|3010734_3010953_+|hypothetical-protein
MEIEALGRAGNVQLARDLGRKFPGLLIQGDTLRILLSDLEEEAPESFALETVRDWIATYEELMAQRGLRLPY
>NZ_CP011502.1|WP_169795973.1|3010239_3010389_-|hypothetical-protein
MLEPLDDRLRDDDVLDEIELTSRLIIAASGRETPMSQAEIDAFLGLDVH
>NZ_CP011502.1|WP_067860143.1|3009531_3010149_-|DUF47-domain-containing-protein
MRFRIRPVETTFYDLFAESASHLVDGANLLAQVLDPDVDRTALAEQMRDAEHQADETTHKIVKRVNSTFVTPFDREDIYRLASSLDDVMDFMEETVDLIGLYEIKELPAQFAAQVEVLQRACQLTAEAMPRLRTMKDLEEYWIEINRLENQGDRSYRRILADLFGGGYKSLEVLKLKDVVDSLEHAIDALESVANTVEQIAVKES
>NZ_CP011502.1|WP_067860141.1|3008502_3009528_-|inorganic-phosphate-transporter
MDLVLAMVIAVVVIALVFDYTNGFHDAANAIATSISTRALTPRIALAMAAVLNFVGALLGVGVAQTIQGIIDIDSQVSSGVSIDRAHGLTIVLAALVGAITWNLITWYFGIPSSSSHALIGGIVGAGAASSTTVDWGTLVEKVAIPMVASPLIGFVGAFALMTAIMWIFRRANPGKVSRGFRHAQTVSAAGMSLGHGLQDAQKTMGVIVLALVAGGFEDGSDVPLWVIVAAASAIAAGTYSGGWRIMRTLGRRIIDLDPPRGFAAEGVAATVLYVMAIGLHAPVSTTHTITSAIMGSGATKRFSAVRWGVAKGIVTAWIVTIPAAAAVAAVFYFIARLFLP
>NZ_CP011502.1|WP_067860139.1|3007450_3008230_+|phosphate-ABC-transporter-ATP-binding-protein
MAKSIDVSDLNIYYGDFLAVEGVNIAIPARSVTAFIGPSGCGKSTFLRSLNRMHEVIPGAHVQGKVLIDGEDLYADEMDPVNVRRMVGMVFQRPNPFPTMSIYDNVLAGQKLNSKRMKKSESDAIVERSLRSAGLWAEVKDRLSRPGSGLSGGQQQRLCIARAISVEPEVLLMDEPCSALDPISTSVIEDLIHELKEKYTIVIVTHNMQQAARVSDETAFFNLSGVGKPGKLVESGRTEKIFSNPDEEATEAYIQGRFG
>NZ_CP011502.1|WP_067860157.1|3015880_3016990_-|LLM-class-flavin-dependent-oxidoreductase
MTAFHWFLPTTGDGRTLVGGGHGVPGGLGHPGGRAGTANAFRPPSIDYLAQVARTAELLDYEGVLTPTGTWCEDAWLTTAALVRETSRLKFLVAFRPGSIEPTLAAQMAATYQRLSNGRLLLNVVTGGEPAEQARFGDRLTQEQRYARTDEFLTVVRGAWDGGFDFTGEYYDVRDARTREAPDPLPELYFGGSSPAAGPVAAKHVDVYLTWGEPVDLVAEKLDWIRGLAKEQGRELRFGIRLHVITRDTSEAAWAVAQQMLDELDPAVVAQAQDTLGASLSVGQQRMRALHEGRRDARDAHDLEVAPGLWAGVGLVRGGAGTALVGSHREVAELVEQYRAIGIEEFVLSGYPHVEEAYWFAEGVRPLLG
>NZ_CP011502.1|WP_067860159.1|3016986_3018000_-|ABC-transporter-substrate-binding-protein
MNRSRLALPAVLAAAALVIAGCGGSSNADAVGADGTVDLSKVTLVVGDQKGGSEALLTAAGELDDVTYDVQWKPFTSGPPLLDAVASGAVDVGGVGNTPPLFAIDQDKKLKVVQASKQGAQGDAIVVPKGSDVTSVADLEGKKVAVAKGSSANYHLLAQLKTAGLTLDDIDPVWLQPAEGLAAFTGGHVDAWSIWDPFTSQAEVANGAKVLVTGDGVVNGLAFQVASDDALDDPATEAAVSDYLQRLARAQAWANSHRSEWAKAWAKETGLPADVTESAIGRRTYQPIPVADAVPSEQDMWDAFVAQGQLSRDVSLADYFDDRYDDAVLAAAKGAGA
>NZ_CP011502.1|WP_067860161.1|3017996_3018788_-|ABC-transporter-ATP-binding-protein
MATRLNAPHALRAPTVPPTVQVRGLRRAFGDTVVLDDLDLDVAPGELVALLGRSGSGKSTLLRLLAGLDAPDAGTAEVDGVTSVAFQEPRLLPWRRVAQNVALGLRTGSRRERDERARQLLGEVGLTEKADVWPVTLSGGQAQRASLARALVSEPGLLLLDEPFSALDALTRIEMHDLLLRVWARHRASVLLVTHDVDEALLLADRVIVLDQGRVAHSLRLDLPRPRALHDPRLVAHRATLLDQLGVRPSSATLTSTAQEAIS
>NZ_CP011502.1|WP_067860163.1|3018772_3019573_-|ABC-transporter-permease
MSLTAPLARTRRPRRPGQPRRAWRRAISPLALLAVWQLASSTGVLPREKLDSPLNVLDSLVGLWTDGRLLDAIQVSVTRVLVGFVLGAVVGVGLAVLAGLSRLGEDVVDAPMQMLRTLPHFGLLPLFILWFGIDEAPKYALIALGVAFPLYVNTFAGIRGVDPKYLDAARAFGLGWTERLRHIVLPGALPSTLVGLRLSLGVAWLTLIVAEQINTTAGIGYLVSDAAGFGRTGEVVAGLLIYSVLGLLTDALVRILERKALAWRLG
>NZ_CP011502.1|WP_083516469.1|3019666_3020419_-|SDR-family-NAD(P)-dependent-oxidoreductase
MKDNSSDTRDTDTRHTDTRATTRKVLVVGATRGLGLAVVEEYVGRGAHVVATERSDGPSGLRTLAERHREAVEVERLDVTRPEQVAALRERLRGRTFDLLLVVAGISLAPQEAVGVDIATDDFTRMMETNVLGVMRTVEGLDGLVAADGTVAVMSSGQGSVANNTSGGFEVYRATKAALNQMVRSYAVRQAGGSRSILLLAPGWVRTDMGGSGATLEVSESIPPLVDTIEAQRGRPGLRFLDRHGDDVPW
>NZ_CP011502.1|WP_067860165.1|3020507_3021065_+|TetR/AcrR-family-transcriptional-regulator
MTDSQPTRAQRREATAARILEAAQEEFGTHGDGATIRGIARRAGVDPSLVLQHYGSKQALFALAVRPVDDLDHDDVPRHLEEVLDVRLHELPAPTRALLRSMLTSPQAAEVMSTYLQERAATLAATMDDEQAATRAALVVSSIMGVTIARHFLDLPGLADASGSDLAELVERWLEPGPDRPARQG
>NZ_CP011502.1|WP_158509216.1|3021071_3022460_-|AMP-binding-protein
MTDLPIGRAFAVLAERSPDAVAVRDGDDVWTRRRLEDDTNRLARAWSDRVGVDDVVTVVLPSGIDLVRACVAAWKLGATPQPLAPTLDVAERQAVLDLTGPALVIDASLGEVDGDPRPLPDAVASSWKAPTSSGSTGRPKVVRAAAPATVDLDRPVAPFVPRHAVQLVASPLFHAAPFVYAMRGLMTGHELVLMPTFEPAEWLRLVERRRVTWSVLVPATMHRVHRLGPDALAAADVSSLEQVLHLGARCPAWLKRAWIDWLGPERVVEVYAGTESQGVAMITGEEWLAHPGSVGRGCGGTRFRVARPDGEDCAPGERGEILMRRDHPTYSYVGAEPTVRDGWHTLGDVGYLDAEGFLYVEDRLADVVTTGGTVVYPADVEGVLEAHPDVRACVVVPADDDRLGQVVHAVVETDADLADLERWAAERLAPERRPRSWQRVTERLRPDTGKVNRSRWRPSADG
>NZ_CP011502.1|WP_067860168.1|3022456_3023551_-|MSMEG_0565-family-glycosyltransferase
MRVALLTYSTKPRGGVVHTLALAEALARAGADVDVWTLARGGDRTFFRAVDPAVGLRPVPFPDVPGEAVGARILRSIRTLRDALRGAEYDVVHAQDCISANAALAAGLRCLRTVHHLDTFTTPELVACHDRAVLEPAGHVCVSEAVAREVREQYGVQPVVIANGVDAGRFEQAASPAAAPQRDRWRDQLGHYVLAVGGIEPRKGSIDLLEAFALLRPRHPHLRLVLAGGETLFDYRDYRAAFDRRARDLGVEPTMLGVVDDDALPSLVAAARTMAFVSTKEGFGLAALEALAAGVPVVARDLPVLREVFGSTVAFATDPAGIAEAVDGVLRGPTDAVPGRGLARSYTWDAAARAHLEVYAGHAS
>NZ_CP011502.1|WP_067861842.1|3023547_3024393_-|carbon-nitrogen-hydrolase-family-protein
MRIGAVAAHFGRDLDRALAKVRAIIDSARADGVELLVLPDATLGGYLTDLRDPRADLPPTLAQDDPRLAEVAAAAGDMVVCLGYTESAEVDGEQLRHNAALCVSGDGVLGRHRKVHQPLGESLVYAPGDRFEAFDTPLGRLGMLIDYDKTFPESARSLALDGAHVVACLSAWPASVTDRASRLPQDRQSRLFDLYDSARAAENQVVWASSNQTGVLGGLRFLGQAKVVGPGGDVLARTWSKGGIAVADVDVEHEVARSRRVLHHLDELRPDSYVTTGRDPS
>NZ_CP011502.1|WP_067860170.1|3024392_3025643_-|MSMEG_0569-family-flavin-dependent-oxidoreductase
MTRVAIVGAGQAGLSVSHHLTRLGVEHVLLEAATPAHEWADNRWDNFTLVTPNWHCRLPGHVYEGPDPDGFMTRDEVVAWLDDYVRSFDPPVRTHTRVVEARERDGGGFVLDLETPDGPDTLEADDVVVATGGYHRPIEPAFARAIDPSVTQLHSQQYRNADQLPEGGVLVVGTGQSGAQIAEDLHLEGRQVHLALGDAPRVARFHRGRDCMTWLADMGLYDTAVAQYPGGLAAREKTNHYVTGRDGGRDIDLRAFALDGMRLYGKLTDAQGTDLTFAPTLTRSLDAADAVYTSIRRDIDRFIEREGIDAPPEPDYVPPWAPDADPTSLDLAAEGITSVVWAIGYRPDYRWLRVGVFDGTGRPTHTRGVTAVPGLFFVGLPWMHTWGSGRFLGVAADAEHVAQCIVGARRSVPAEA

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Crispr_ID: NZ_CP011502_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_16

3108952-3109144

Orphan

Consensus_repeat	Method
GCCCTCGGCGCCACCGTCAGCG	CRT

3 spacers

DEDDh

The CRISPR arrays of NZ_CP011502_16

>merge|NZ_CP011502|16|3108952-3109144|CRT
ACCGTCGGCGCCACCGTCCTGCACGCCCGGCGTGCCCTCGGCGCCACCGTCAGCGGGGCCCTCGGCGCCACCGTCAGCGCCGCCGTCCTGCACGCCCGGCGTGCCCTCGGCGCCACCGTCAGCGGGGCCCTCGGCGCCACCGTCGGCGCCGCCGTCCTGGACACCCGGGGTGCCCTCGGCGCCACCGTCAGCG

>NZ_CP011502|16|1|3108952-3109144|CRT
ACCGTCGGCGCCACCGTCCTGC	ACGCCCGGCGTGCCCTCGGCGCCACCGTCAGCGGG
GCCCTCGGCGCCACCGTCAGCG	CCGCCGTCCTGCACGCCCGGCGT
GCCCTCGGCGCCACCGTCAGCG	GGGCCCTCGGCGCCACCGTCGGCGCCGCCGTCCTGGACACCCGGGGT
GCCCTCGGCGCCACCGTCAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067860285.1\|3100445_3101207_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187629
NZ_CP011502.1\|WP_067860288.1\|3101220_3102360_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NZ_CP011502.1\|WP_067860295.1\|3104168_3104981_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP011502.1\|WP_067860293.1\|3103470_3104172_+\|lysoplasmalogenase	unknown	unknown	gnl\|CDD\|377946
NZ_CP011502.1\|WP_067860301.1\|3106772_3107678_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227101
NZ_CP011502.1\|WP_067860316.1\|3114162_3115629_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NZ_CP011502.1\|WP_067860318.1\|3115953_3116487_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_144433809.1\|3115558_3115957_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_144433808.1\|3109930_3111079_-\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP011502.1\|WP_067860312.1\|3112686_3113178_+\|inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|376376
NZ_CP011502.1\|WP_067860290.1\|3102495_3103461_+\|sensor-domain-containing-diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP011502.1\|WP_067860299.1\|3105915_3106731_-\|hypothetical-protein	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|181176
NZ_CP011502.1\|WP_067860305.1\|3109250_3109868_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378373
NZ_CP011502.1\|WP_067860322.1\|3116731_3117292_-\|stage-II-sporulation-protein-M	unknown	unknown	gnl\|CDD\|376676
NZ_CP011502.1\|WP_067861876.1\|3107685_3108855_-\|cupin-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|369647
NZ_CP011502.1\|WP_144433810.1\|3116483_3116714_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067860310.1\|3111184_3112588_-\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl\|CDD\|200042
NZ_CP011502.1\|WP_067860297.1\|3105052_3105919_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|235628
NZ_CP011502.1\|WP_083516478.1\|3113480_3114164_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP011502.1\|WP_067860283.1\|3099644_3100412_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|235852

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067860285.1\|3100445_3101207_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187629	cd05371, HSD10-like_SDR_c, 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs. HSD10, also known as amyloid-peptide-binding alcohol dehydrogenase (ABAD), was previously identified as a L-3-hydroxyacyl-CoA dehydrogenase, HADH2. In fatty acid metabolism, HADH2 catalyzes the third step of beta-oxidation, the conversion of a hydroxyl to a keto group in the NAD-dependent oxidation of L-3-hydroxyacyl CoA. In addition to alcohol dehydrogenase and HADH2 activites, HSD10 has steroid dehydrogenase activity. Although the mechanism is unclear, HSD10 is implicated in the formation of amyloid beta-petide in the brain (which is linked to the development of Alzheimer's disease). Although HSD10 is normally concentrated in the mitochondria, in the presence of amyloid beta-peptide it translocates into the plasma membrane, where it's action may generate cytotoxic aldehydes and may lower estrogen levels through its use of 17-beta-estradiol as a substrate. HSD10 is a member of the SRD family, but differs from other SDRs by the presence of two insertions of unknown function. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	5.96212e-111
NZ_CP011502.1\|WP_067860288.1\|3101220_3102360_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	1.10274e-167
NZ_CP011502.1\|WP_067860295.1\|3104168_3104981_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	3.66686e-43
NZ_CP011502.1\|WP_067860293.1\|3103470_3104172_+\|lysoplasmalogenase	gnl\|CDD\|377946	pfam07947, YhhN, YhhN family. The members of this family are similar to the hypothetical protein yhhN expressed by E. coli. Many are annotated as possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues. A human member of this family, formerly known as TMEM86B, is a lysoplasmalogenase that catalyzes the hydrolysis of the vinyl ether bond of lysoplasmalogen. Putative conserved active site residues have been proposed for the YhhN family.	1.82269e-16
NZ_CP011502.1\|WP_067860301.1\|3106772_3107678_-\|hypothetical-protein	gnl\|CDD\|227101	COG4759, COG4759, Uncharacterized protein conserved in bacteria containing thioredoxin-like domain [Posttranslational modification, protein turnover, chaperones].	7.7915e-24
NZ_CP011502.1\|WP_067860316.1\|3114162_3115629_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	1.28968e-99
NZ_CP011502.1\|WP_144433808.1\|3109930_3111079_-\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	6.22867e-06
NZ_CP011502.1\|WP_067860312.1\|3112686_3113178_+\|inorganic-diphosphatase	gnl\|CDD\|376376	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase.	1.29465e-79
NZ_CP011502.1\|WP_067860290.1\|3102495_3103461_+\|sensor-domain-containing-diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.73865e-40
NZ_CP011502.1\|WP_067860299.1\|3105915_3106731_-\|hypothetical-protein	gnl\|CDD\|181176	PRK07942, PRK07942, DNA polymerase III subunit epsilon; Provisional.	1.4203e-57
NZ_CP011502.1\|WP_067860305.1\|3109250_3109868_-\|hypothetical-protein	gnl\|CDD\|378373	pfam10060, DUF2298, Uncharacterized membrane protein (DUF2298). This domain, found in various hypothetical bacterial proteins, has no known function.	0.00733909
NZ_CP011502.1\|WP_067860322.1\|3116731_3117292_-\|stage-II-sporulation-protein-M	gnl\|CDD\|376676	pfam01944, SpoIIM, Stage II sporulation protein M. SpoIIM is on e of four stage II sporulation proteins that is necessary for the forespore inside the mother-cell to be properly internalized through the breakdown of peptidoglycans trapped between the membranes of the septum separating the forespore and the mother-cell. The four proteins working in sequence are SpoIIB, pfam05036, SpoIIM, SpoIIP, pfam07454, and finally SpoIID, pfam08486. D, M and P are in a complex with each other and the complex assembles in a hierarchical manner such that M, which serves as a membrane anchor, recruits P to the septum and P, in turn, recruits D to the septum.	4.4692e-05
NZ_CP011502.1\|WP_067861876.1\|3107685_3108855_-\|cupin-like-domain-containing-protein	gnl\|CDD\|369647	pfam08007, Cupin_4, Cupin superfamily protein. This family contains many hypothetical proteins that belong to the cupin superfamily.	2.74143e-31
NZ_CP011502.1\|WP_067860310.1\|3111184_3112588_-\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl\|CDD\|200042	TIGR00666, D-alanyl-D-alanine_carboxypeptidase_DacB, D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family. In E. coli, this protein is known as penicillin binding protein 4 (dacB). A signal sequence is cleaved from a precursor form. The protein is described as periplasmic in E. coli (Gram-negative) and extracellular in Actinomadura R39 (Gram-positive). Unlike some other proteins with similar activity, it does not form transpeptidation. It is not essential for viability. This family is related to class A beta-lactamases. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	3.63702e-52
NZ_CP011502.1\|WP_067860297.1\|3105052_3105919_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|235628	PRK05855, PRK05855, SDR family oxidoreductase.	1.78897e-27
NZ_CP011502.1\|WP_083516478.1\|3113480_3114164_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.64852e-11
NZ_CP011502.1\|WP_067860283.1\|3099644_3100412_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|235852	PRK06688, PRK06688, enoyl-CoA hydratase; Provisional.	1.85053e-69

>NZ_CP011502.1|WP_067861876.1|3107685_3108855_-|cupin-like-domain-containing-protein
MRRLVVDPVGFAADTWGRAPLLTRAADLPGAFDDLFGETAVDDLVSTHGLRTPFLRVAKDGSTLPTRAFTSGGGVGAGIADQVDDTRLTALFADGATLVLQALHRTWPPVVAFAQQLVADLGHPVQVNAYVTPPQSRGFDDHYDVHDVFVLQISGAKRWRIHAPVHEAPLRDQPWTDRREAVRAEAERECLIDEVLEPGDVLYLPRGTLHAATALGDVSTHLTFGVHTWNRHHLAEEVVAAALAAVADDPDVRTSLPLGVDVADPDDLHAHAELVRDRLLAAVRAVPTDTLAAALGGRDGTSGRAAPVGPLAQLRLAQGLTDDTALVLRGSLAAHVADGHLRGRGVDVDVADLEADVLHGLLDGQVVTVARLGHETARRLVAAGVLVAA
>NZ_CP011502.1|WP_067860301.1|3106772_3107678_-|hypothetical-protein
MADLDDLCAARARVRADPLPGTALHVQRLLLVEHQGPWPFHALESEGLDPDVVARLVEATREAGGRTVLIRRPGRRSDADGPRAWAVVDVPAGRLRWGTWTEPADLLDSCPVLREPADHDGWTDEPAVLVCAHGRHDTCCAVRGRPVAAALAERFGDAVWECSHVGGDRFAANVVVVPDTTYYGGLDDDTSLDVIDEHLAGRVTPWALRGSSAMPPVAQAAAVAVHERWGPAGPRDVQCVEVTALAGDRWRVRLSCDGILPPRVVADVRAVQREAAVLTCQAPRATSARAFVVDALEPDGR
>NZ_CP011502.1|WP_067860299.1|3105915_3106731_-|hypothetical-protein
MRTNRFEGFCAACTLHVLAGAGRLTGTPGAWRTWCVACAPRPPARGGHDGWHRLPLASLDLETTGTDALHDRVVSFALLDEPGFEIAGLVRPDVPVPEAAAAVHGITDAMLQDAPTSAEALPVVLDWLATLAERRVGLVVFNACYDLSMLRAEARRHGLAEPDWERLLVVDPYVVDWGIERGALGRRRLGDVAAYYGVALDGAHDATCDAVAARQVAVELAARHADVGTLDLEQLMHAQRGWYAERAEDWNAYARRVGRDLDDPAGWPLVG
>NZ_CP011502.1|WP_067860297.1|3105052_3105919_+|alpha/beta-fold-hydrolase
MAFSETTAVAVGDLTFDVRHAGPDDGTPVVLLHGFPTTSLSWSPVVPALADAGLRVVAPDQRGYSPGARPADVAAYATDRLAQDVVSLADALGLDRFHLVGHDWGAAVAWYVAAHHGHRLETLTTFSVPHLAAYNAALAHDADARERGSYIGLFRREGKAEDLLLADDARRLRAMYQGAVPQHLVDAYVAQLQEPGALTAALGWYRAMTPELAGLPSVDVPTTFVWSDDDLAIGRAGADACGAHVSADYRYEVLEGVTHWIPEQAPDAAAAAILDRVRGVDPEAPRPI
>NZ_CP011502.1|WP_067860295.1|3104168_3104981_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MRPDPTRPARATRRSDRTYRWVNRAGALLLRAWGVRLRARGLEHLPRDGAAVLAANHTGYLDFVLLEWAARQRGRLVRFMSKASVFDAPVVGRLMRAMGHVRVERWTGASAYRHARRLVTSGEVVGVFPEATISRSFRVKRLKPGAAALALHATRTTGVVVPLVPCVVWGGHRLLTVDGRRTLRRGVAVDVVVGEPLLPREDESVAELTARLREALVRLLDDAVGHYPQQPRSDADRWWVHADRGGTAPDVATGAALDRAALQRAGAPSD
>NZ_CP011502.1|WP_067860293.1|3103470_3104172_+|lysoplasmalogenase
MDERHSGGWRGIPFLVAFVAVLSVHLVLLAADATPWDSVTKCLLAPVLVAWVVAERGPGLLVAALVLCLGGDLLLEVDGLFVAGMASFAAAHVCLVTLFVRAGAVRERRPHPLLVATYLLAGVARVAWAWGGLAADLRPVVPVYAVLLLATAVTSSCVDVLAGVGGALFLVSDGLIALGEAGRVDPGSATVSVAVMILYGAAIALLTAGALRVSGDLSTRGPVLRQPSGEPLT
>NZ_CP011502.1|WP_067860290.1|3102495_3103461_+|sensor-domain-containing-diguanylate-cyclase
MEPLSPATGTDTFSAVANRVVEYLRRSTPISDWSVNRRIEGEQVFLHTTNGTLVRVGDRRPWDQSYCHRAFDLGADAIVDDVTTHPQYSDLRIGATRSYAGVPIRDPEGEMFGMLCGLGVDPLDGADVDAELLAVLGDLLGAHLSLARRAESDDRERRTAEALAQTDALTGLVNRRGWDSVLADAAVRASAYGDLAAVVLCDLDGLKDVNDRHGHAAGDTLLQRTAHALTRARGAHDTLARYGGDEFVVLVEDVSPRLLSRTLQRYRDALEHEGVEASFGWSLVFPGDEPVDLAFQRADRSMYEDKRARRAARREPDTAAG
>NZ_CP011502.1|WP_067860288.1|3101220_3102360_-|acyl-CoA-dehydrogenase-family-protein
MPADRLMPTPESADLIALTRELVDDKLRPRVDEAERTATFPRDVFAMLGRAGLLGLPYPEELGGGGQPYEVYLQVVEEIASAWAAVGVGVSVHALSCFGLAEAGTDEQRQRWLPDLLGGDLLGAYCLSEAHAGSDPAAMRTKAVRQGDDYVITGAKAWTTHGGQADFYKVMARTSDEKGRGISCFLVPADAEGLTADVPEQKMGLMSSTTATMLFDGVRVPAERRLGAEGQGLAIALAGLDAGRLGIAAVAVGVAQGALDAAVAYAQEREAFGRAIIDHQGLGFLLADMAAAVDSARATYLHAARLKDAGRPYGRAASVAKLVATDNAMKVTTDAVQVLGGAGYTKDFPVERYMRETKVMQIFEGTNQIQRLVISRHLK
>NZ_CP011502.1|WP_067860285.1|3100445_3101207_-|SDR-family-NAD(P)-dependent-oxidoreductase
MQLTGTSAVVTGGASGLGAATAAALAAAGAAVVAVDLAQSIEKAPDVEGVTYVEADVTDEAQVRNAVAAASEQAPLRVAVSCAGIGTAGRVLGKGGQGIHDLGLFARIVNVNLVGTFTVLAVAAEAMAATEPLEHGQRGVVVNTASIAAFDGQIGQAAYSASKGGVVGMTLPTARDLAQYGIRVNTIAPGIIDTPMLATVGEEIRAALAKGVPFPQRLGRPDEYAQLVRMIVEHDYLNGETIRMDGSLRMAPR
>NZ_CP011502.1|WP_067860283.1|3099644_3100412_-|enoyl-CoA-hydratase/isomerase-family-protein
MTDAPVLLTVDDGVAHVELNRPEASNTIDLPYTAAFADVLTQVRDDDAVRVVLLTGRGRMFCAGGDLGAMDAAPDRSAFLQELADALHVGVRLLDGLEKPVVVGVQGAAAGAGLSLVLGGDLVVAGRSAAFVTAYTSVGLTPDGGQSWLLPRVVGLQRALELTLTPRRLSAEEAQAWGIVTRVVDDEAVADEAHALARRLADGPARAFGRARRLVRGSFGTPLSEQLDREARTIATSVAEPESAALITRFLSRGR
>NZ_CP011502.1|WP_067860305.1|3109250_3109868_-|hypothetical-protein
MSDDQVQRPARDDHDVDRSHGKDERRYVPSEVDPKRWVKRLAAVLVGVAVVYLLALVAGAFFPRWWAQRVADQVNGDITSGVLWGLFYGFVFTIVPLLVVVQLRRRFFSWTWRGILLLVAVVLAAPNWFTLSIVVGAGSAAHAGERILDVDAPGFRVASAIGAVGAVALVVILTVTGALAHRRRRQVRDLKGQLHERDERPGTGA
>NZ_CP011502.1|WP_144433808.1|3109930_3111079_-|peptidoglycan-binding-protein
MRRLGLACVAALLCATTLTAISGTTSTAASSTPVAFPSKPKGLKAPVTLPKDVDPASAYVPQVACQPGTPRGVALTRDLVMRTYGVGGAGNTARSCTEGVSEHADGRAWDWMVDVTKPSERAAAADFLAWLTKDGGTNARRLGVMYVIYNEKIWAIYRAKEGWRPSSGHRDHVHVSFSWNGARGTTSFWTGKVHPVDYGPCARYSGQPGVVNGQARTTPCPALTALVRKTSRSTEELGSRASTVRSAQTALGVKVTGTLDTTTRSALARYQKAHDLPPTATLDQPTWSSLVPASTTWDAAGSMTSGEAARYGAKNYPTTLGPWATGKSVLVLQVALAVPRADRNGYLGPRTVAAVKARQQALGRPVTGRWSKADWAALAAAS
>NZ_CP011502.1|WP_067860310.1|3111184_3112588_-|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MTRRDRGRVGLPWLLGTLVLVGALVAAVAFGWTTGRLNPLVCGGACGPEAVATPAGLTLDTVPERTAPDPVVTRRPDPDAVRAAVGGLLDDPDLGGRVGVSVLALDGTSLLDRDASATFVPASTTKLLTAYATLSRLDPTARFSTSTVLDGEQVVLVGGGDPYLASTRPSRPTRVDRADLRTLARRTADALRAAGRTTVRIGYDAGLFTGPAVNPTWESSYVADQVVTPVSALWADQGERDGVRSTTPAQDATARFAGYLRDAGIRVRGDATRADPGSSAQPLAVVRSATVAQVVDAMLVRSDNEAAEVLLRHVGIAAGGAGSVADGTRAVVATLRENDVPVPGLRLRDGSGLSRANRIAPATLAGVLRAASARAATAPLLADLPVGGFTGTLANRFGTDSAGRGLVRAKTGTLTGVHSLAGYVTDRDGTPLVFAVMTDDTEDVNPFVTQAAVDDVAAALAGCSCGG
>NZ_CP011502.1|WP_067860312.1|3112686_3113178_+|inorganic-diphosphatase
MIFDVTVEIPKGERNKYEVDHKDHRIRLDRTLFTATQYPADYGFIDDTLGLDGDPLDALVLLPSPTFPGCVITCRAIGMFRMTDEAGGDDKVLCVPATDPRQEHLRDIHHVAEFDRLEIQHFFTVYKDLEPGKSVEGSNWTGRVEAEAEIERSFQRFKDNGGY
>NZ_CP011502.1|WP_083516478.1|3113480_3114164_-|TetR/AcrR-family-transcriptional-regulator
MFRILSVSEFRDQCRGPRHREAAVSVDSERGTTRAERQAQTRERLVEVARELFLADGYAGTSLDKVAVAAGFSKGAVYSNFSGKEELCMAVLDTIHEEQVEGVVAAFTADTDLDGRIDAFAAWVREKLGKPRWTALEVEFAAVARQSPWVAGELVKRHRMLVTASADLIDRVLADAGLRLDFGAHKAAVALLSLGIGLGAMRSLDPELDVDVFAETMRALLRSSTSA
>NZ_CP011502.1|WP_067860316.1|3114162_3115629_+|NAD(P)/FAD-dependent-oxidoreductase
MITTDTLVIGTGFSGMGMAMKLREAGRTDFVVIEKADDVGGTWRDNTYPGAECDIQSHMYSFSYELNKDWSREYSGQQEIWEYMRSVARKHDLYDVIHFGTEVTGAVWDEDRLRWTVSTSKETYDARVVVSGIGGLHIPNIPDLPGAESFSGPRFHSAQWQHDVDLTGKKVAVVGTGASAIQFIPQIVGDVAQLDVYQRTAPWVVPKHNHDIEGRKGAFIKRLPGGTRAYRNAMYWLNEAQQLAFTGPLQNVSKVMENKVSDYIRRTVKDPEVAEKLIPDYRLGCKRILKTDNYVPVYNRDNVELVTDGIEEITADGIRAKDGTFREADVIIYGTGFHVTDAFEWVHVTGKGGRDLSKTFKEKGIETYLGISVTDFPNFFFLLGPNTALGHNSVVFMIEQQTKWIIAMLDEMDERGAQAVEPTSQAQREFNDALQEKVSKGVWSQGGCTSWYLDSQGKNRTIWPGFTFRYWWATRKVEAQDFAWEKAA
>NZ_CP011502.1|WP_144433809.1|3115558_3115957_-|hypothetical-protein
MSRRLAVVVVLLVAGVVTLAALALQHRVDGRRADATRAFAQVVPGLSEREVRAILGPPDPTVQDLAPPGGGCVVYVRADRTTDPFVALCFVDGRLRCLSTVGPPTGRERVRPPSPTRSPAPRPCASPTSSGT
>NZ_CP011502.1|WP_067860318.1|3115953_3116487_-|hypothetical-protein
MTRRRRPALLVGAQVLAAYVLVACVALEAGTRRGGASLDAVPGEHPRGVVVSLGVLVLLSLPVVVLLALLLSAAMLQVALGLLDVELTLGRAVEVMLWAAVPLAIRNVLLGGVALAVGGEQAAALIRFGDPFVLAAAVVVVARLHALGVQTWRATAAALFVVGLPIVLQVVLGSSAA
>NZ_CP011502.1|WP_144433810.1|3116483_3116714_-|hypothetical-protein
MEENAPAHGLPVVLSVLLSLAALLLGWRGDIGVAWAVVAVLLAGAAPALALLPHGRWPSVLALLGSVVTLALAVAA
>NZ_CP011502.1|WP_067860322.1|3116731_3117292_-|stage-II-sporulation-protein-M
MSVSATRRPGAARRPGTTTRLVAGFLVVVLVAVVAGTVAGHAHPAEAERSRGRPAHAEEILQHNLVVLVVVGVLALLSVGLLAVLYLLPSFWIVGFQVGQSWQEHGPGPTLHGLLWHAPLELTAFALCAATATVQSRRLWSAAGGRERGATRAAEVLGPLLRGWVTSVGLLVLAALVEASLSAGPR

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Crispr_ID: NZ_CP011502_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP011502_17

3223977-3224069

Orphan

Consensus_repeat	Method
AACTCCCCCACGCAAACGACAGCCCCCAGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP011502_17

>merge|NZ_CP011502|17|3223977-3224069|CRISPRCasFinder
AACTCCCCCACGCAAACGACAGCCCCCAGCGCCTGTTTACGTGGGGCCCCACCCAAAAGTGAACTCCCCCACGCAAACGACAGCCCCCAGCGC

>NZ_CP011502|17|16|3223977-3224069|CRISPRCasFinder
AACTCCCCCACGCAAACGACAGCCCCCAGCGC	CTGTTTACGTGGGGCCCCACCCAAAAGTG
AACTCCCCCACGCAAACGACAGCCCCCAGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP011502.1\|WP_067860487.1\|3212384_3213773_-\|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|236520
NZ_CP011502.1\|WP_067860506.1\|3225200_3226169_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP011502.1\|WP_067860491.1\|3216370_3218995_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP011502.1\|WP_067860500.1\|3222951_3223872_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235633
NZ_CP011502.1\|WP_067860489.1\|3213778_3215329_-\|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|236507
NZ_CP011502.1\|WP_067860508.1\|3226355_3226844_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377576
NZ_CP011502.1\|WP_083516652.1\|3235173_3237207_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|350677
NZ_CP011502.1\|WP_067860492.1\|3219085_3219778_-\|DUF4272-domain-containing-protein	unknown	unknown	gnl\|CDD\|379466
NZ_CP011502.1\|WP_158509218.1\|3219774_3220401_-\|suppressor-of-fused-domain-protein	unknown	unknown	gnl\|CDD\|377450
NZ_CP011502.1\|WP_067860510.1\|3226943_3227786_+\|Ku-protein	unknown	unknown	gnl\|CDD\|238408
NZ_CP011502.1\|WP_083516490.1\|3230459_3231923_+\|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|237234
NZ_CP011502.1\|WP_083516488.1\|3215601_3216270_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|377857
NZ_CP011502.1\|WP_067860498.1\|3221912_3222857_-\|1,4-dihydroxy-2-naphthoyl-CoA-synthase	unknown	unknown	gnl\|CDD\|181386
NZ_CP011502.1\|WP_067860518.1\|3234456_3235032_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067860504.1\|3224862_3225210_+\|DUF3817-domain-containing-protein	unknown	unknown	gnl\|CDD\|378962
NZ_CP011502.1\|WP_067860512.1\|3227795_3230405_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|236599
NZ_CP011502.1\|WP_067860516.1\|3231919_3233842_+\|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl\|CDD\|225922
NZ_CP011502.1\|WP_067860502.1\|3224107_3224749_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153159
NZ_CP011502.1\|WP_067860496.1\|3221030_3221726_-\|DUF3800-domain-containing-protein	unknown	unknown	unknown
NZ_CP011502.1\|WP_067860494.1\|3220571_3220913_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP011502.1\|WP_067860487.1\|3212384_3213773_-\|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-beta	gnl\|CDD\|236520	PRK09444, pntB, Re/Si-specific NAD(P)(+) transhydrogenase subunit beta.	0
NZ_CP011502.1\|WP_067860506.1\|3225200_3226169_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.1448e-36
NZ_CP011502.1\|WP_067860491.1\|3216370_3218995_-\|GGDEF-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.96074e-88
NZ_CP011502.1\|WP_067860500.1\|3222951_3223872_+\|SDR-family-oxidoreductase	gnl\|CDD\|235633	PRK05872, PRK05872, short chain dehydrogenase; Provisional.	2.62831e-106
NZ_CP011502.1\|WP_067860489.1\|3213778_3215329_-\|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-alpha	gnl\|CDD\|236507	PRK09424, pntA, Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha.	0
NZ_CP011502.1\|WP_067860510.1\|3226943_3227786_+\|Ku-protein	gnl\|CDD\|238408	cd00789, KU_like, Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku homologs are predicted to form homodimers. It is proposed that the Ku homologs are functionally associated with ATP-dependent DNA ligase and the eukaryotic-type primase, probably as components of a double-strand break repair system.	3.20021e-116
NZ_CP011502.1\|WP_083516652.1\|3235173_3237207_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|350677	cd17919, DEXHc_Snf, DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins. Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	5.93796e-46
NZ_CP011502.1\|WP_067860502.1\|3224107_3224749_-\|hypothetical-protein	gnl\|CDD\|153159	cd04887, ACT_MalLac-Enz, ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains. The ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI, a malolactic enzyme (MalLac-Enz) which converts malate to lactate, and other related ACT domains. The yqkJ product is predicted to convert malate directly to lactate, as opposed to related malic enzymes that convert malate to pyruvate. Members of this CD belong to the superfamily of ACT regulatory domains.	7.14675e-21
NZ_CP011502.1\|WP_158509218.1\|3219774_3220401_-\|suppressor-of-fused-domain-protein	gnl\|CDD\|377450	pfam05076, SUFU, Suppressor of fused protein (SUFU). SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.	1.58929e-47
NZ_CP011502.1\|WP_067860512.1\|3227795_3230405_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|236599	PRK09632, PRK09632, ATP-dependent DNA ligase; Reviewed.	0
NZ_CP011502.1\|WP_083516490.1\|3230459_3231923_+\|glucose-6-phosphate-dehydrogenase	gnl\|CDD\|237234	PRK12854, PRK12854, glucose-6-phosphate 1-dehydrogenase; Provisional.	0
NZ_CP011502.1\|WP_083516488.1\|3215601_3216270_-\|HNH-endonuclease	gnl\|CDD\|377857	pfam07510, DUF1524, Protein of unknown function (DUF1524). This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.	2.13109e-17
NZ_CP011502.1\|WP_067860498.1\|3221912_3222857_-\|1,4-dihydroxy-2-naphthoyl-CoA-synthase	gnl\|CDD\|181386	PRK08321, PRK08321, 1,4-dihydroxy-2-naphthoyl-CoA synthase.	0
NZ_CP011502.1\|WP_067860504.1\|3224862_3225210_+\|DUF3817-domain-containing-protein	gnl\|CDD\|378962	pfam12823, DUF3817, Domain of unknown function (DUF3817). This domain is of unknown function. It is sometimes found adjacent to pfam07690 and pfam03176 which are both transporter domains.	1.04994e-25
NZ_CP011502.1\|WP_067860516.1\|3231919_3233842_+\|glycoside-hydrolase-family-15-protein	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	4.3278e-100
NZ_CP011502.1\|WP_067860492.1\|3219085_3219778_-\|DUF4272-domain-containing-protein	gnl\|CDD\|379466	pfam14094, DUF4272, Domain of unknown function (DUF4272). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 221 and 399 amino acids in length.	3.38879e-35
NZ_CP011502.1\|WP_067860508.1\|3226355_3226844_+\|hypothetical-protein	gnl\|CDD\|377576	pfam05957, DUF883, Bacterial protein of unknown function (DUF883). This family consists of several hypothetical bacterial proteins of unknown function.	0.00391764

>NZ_CP011502.1|WP_067860500.1|3222951_3223872_+|SDR-family-oxidoreductase
MALFARKGFTGKVLLVTGAARGIGAGVARAYVAQGGKVALLGLEPDLLEALAAELGPAAAWWEADARDGRAMTEAIDAAAAHFGRIDHVLANAGIASYGTVRQIDEASFERVVDINVNGVYRTLHASIPHLERTRGYALVVASLAAFTNLAGLASYNASKAGAESLALATRQEVAHLGIKVGVAHPSWIDTDIVRGAEADLPTFKTIRGKLPYPANSTTTLADCVDAIVAGLRRRKTRVYVPRGVLLANWTKPLLNSPVAWLFMRPQLKRHVPDLEREVAALGRFQHAHVPLTDPKKPLEETPSTP
>NZ_CP011502.1|WP_067860498.1|3221912_3222857_-|1,4-dihydroxy-2-naphthoyl-CoA-synthase
MSALPGVSETFDPSAWDEVPGFEHLTDVTYHRARAHGTVRVAFDRPDVLNAFRPQTVDELLQVLDHARTSADVGCVLLTGNGPSEKNGKRSFCTGGDQRIRGRFGYQYEDGEASGSDTGAEEPSPIDKARLARLHILEVQRLIRFMPKIVICVVPGWAAGGGHSLHVVADLTLASAEHARFKQTDADVGSFDGGFGSAYLARQVGQKFAREIFFLADEYSAEDGVRMGTVNRAVPHDELEATALEWGRKINAKSPTAQRMLKYSFNLIDDGLVGQQVLMGETTRLAYMTDEAQEGRDQFLEKRDPDWSPFPWYY
>NZ_CP011502.1|WP_067860496.1|3221030_3221726_-|DUF3800-domain-containing-protein
MRELSIFVDESGDFGPFEKHSPFYVLSLVFHDQSDDIAQHLEKIRDALVARGLPADHAIHTGPLVRREQDYRLLDMPSRRSIFRVLVDFVRTSEVTHHSWVFSKRELGDTDRLVSAMSRELGELIRSSYEFFSSWERIVIYYDNGQKEITNLVNSVFNAHLSVEVRKVIPADYSLFQAADLCCTLSMLRRKIETSGLSASERGFFSTSKDSAERALRKGYFKSLDRQRFGG
>NZ_CP011502.1|WP_067860494.1|3220571_3220913_-|hypothetical-protein
MDSTTLWRPTGPQELALVEASGWRAWPPRLPDQPIFYPVLNEDYAVRIARDWNVPASGVGYVTRFEVETSFLDAYDVQQAGGDTILEYWIPAEDLAGLNEHIVGTIDVVQVFR
>NZ_CP011502.1|WP_158509218.1|3219774_3220401_-|suppressor-of-fused-domain-protein
MDAVDRHLEQWVGPVETVFHEIVSDLVHVDVHLVPAGEGRPFHTLATSGMSDRRMTVPQDLQGQVPDRVEVMVMLPPDWPVDEASWVDERSYWPVRALKVLARFPHEYETWLGAWHSLPNGDPAEPYADDTRFCGLMLAPPLRLPQGARTFRTDDGREVALLAMLPLLPDELEMKLTEGVDGLLDGLDAHGVTELLDPDRPSVLGPPR
>NZ_CP011502.1|WP_067860492.1|3219085_3219778_-|DUF4272-domain-containing-protein
MRWSRGRDASRGHGDAAAEARRRSLAALPGLGFPQPPSHLPPVADAADPLVLVDEEQVMQRALVLTVRVNLALRMPPELARAWLAEQGLLASLSPRERALLSGEVEPDYSDEAQVEALWALAWVLGLVPELDASAPCGDQLASLMPDLRTSEPVAAWRSRTGPRRRDVEDVLPVLDLHLALTWGITDARLAGRPHPGRVDPSVLWERRRALEWTAGDGVHDSWDDVDLST
>NZ_CP011502.1|WP_067860491.1|3216370_3218995_-|GGDEF-domain-containing-protein
MERLLGLESSAPRTRTRSAALALGFAVLFALAFLAGRATRVPPAQLALAWPAAGVVILWLLAARSSLERIVACVVVVVVSGVLNQLTGTEPLGAWLFGLVNLSHGAVGAVLLHRWRPAWLRSTWTTLGDVGVLLGVAAAAATTSGLLGSLVAWWRFDEPFLEGLFIIGFRNVVSSFVVLNALLALPQLWRTRRERGAGCPLTVAAGLVVTGALLWLPWPVDFAIVPIVVVVALRCGAQATSVLVALQGVLVVAATVAGNGQFASLDDPQARVVAAQAFVLVLAVVGVVLATLEDARDAALVQSRRDRDQLQDHMEAALLASAHVVVDPDGFVHVDAVNAALVTLTGRPRHALLGVDPRTWFVDDDVEAFRQGVCELTLGRALGWRTQLRLDDAWGGGWVDVALALVDPDLDPSLSLGGSGASSAAITLQMIDVTAQKEAEQALAHAALHDDLTGLANRALWADSLERAAQVVGSERPALAVMFIDVDRFKQVNDGRGHAVGDAVLVELAERLSALVGDGATVARLGGDEFVVLCTSAGTREELAAEAQRIMDRLSEPVVLQDGTTVSVTVSIGIAAADEQAEAPLLLRHADQALYAAKDRGRGRAEFYDPTVHAGIESSARLLVDLERAQASGEFSLVFQPIVDVATGYLHAVEALLRWDHPIRGQLRPGDFMPVLEVSDLMHQVGDGVLRGACAHAAALAAQGTPVPVHVNVSAVELGRAGLVARVLSVLDEVGLPPSMLVLEITETQLLDVTGGLVVDLFALRDHGVRIAVDDFGTGYSTLAHLVDLPVDVVKLDGSFVARMTHSRRARSVCAGVVAMAQGIGIDVVAEGVETAEQQTALESLGYRLLQGYHLGRPAPATPPTAGVGAQGRG
>NZ_CP011502.1|WP_083516488.1|3215601_3216270_-|HNH-endonuclease
MPLRAASSTVHVRPAVGRRRRRLTHVVGLLVATLVATVLVAPAASASPESQLAELTVRAEANGTTYDRDAFRHWIDADGDGCNTRAEVLMDESSSATGRTGTCTITSGSWLSRYDNVRFTDAGSLDIDHMVPLKEAWISGASGWTASRRESFANDLGDARSLIAVSASTNRSKSDQDPDSWLPPATGYRCTYVSDWIAVKYRWGLSVDSAEKAALQDVLAGC
>NZ_CP011502.1|WP_067860489.1|3213778_3215329_-|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-alpha
MRIGVVAESRAGETRVAATPATVARLLKLGYDVSVESGAGAKAAFADEAFAEAGASVVTGEEAWTADVVLKVNPPSTAEIDRLNDHATLVSLIAPATSPELLEALSARPLTVLAMDAVPRISRAQSMDVLSSMANIAGYRAVVEAAHEFGRFFTGQVTAAGKVPPAKVLVAGAGVAGLAAIGAASSLGAIVRATDPRPEVADQVKSIGGEYLAVDVEVEKSTDGYAKATSEEYDRRAAEIYSEQAADVDIVVTTALIPGRQAPRLLTEADVASMKPGSVIVDMAAAQGGNVAGSVAGEKVVTANGVTILGYTDLAGRLPTQASQLYGQNLVNLLTLLTPGKDGQLVLDHSDVVQRGVTVVHDGDVLWPPPPVQVSAAPAPTAEMPAVQEKPEPRPGLTQRGKYLLIAAGIAALFLVNAYAPPPLPEHFFVLTLSVVIGYYVIGKVHHALHTPLMSVTNAISGIIVVGALLQIGVGDGADNAWAIRLLAFVAVLLASINIFGGFAVTRRMLSMFSKG
>NZ_CP011502.1|WP_067860487.1|3212384_3213773_-|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-beta
MTAQSIATAAYIVAALLFILSLAGLSKHETARSGVAYGIAGMTIALVATIVLAVEDAETVGVVLLVGAIVIGAGIGIWRAREVEMTGMPELIALLHSFVGMAAVLVGWNGYLEHPVYPLESLERIHSAEVFVGVFIGAVTFTGSIVAYLKLSARIKSSPLVLPGKNYLNIGALVLFFVLTVVFVASPNIWLLILVTALALALGWHLVASIGGGDMPVVVSMLNSYSGWAAAAAGFLLSNNLLIVTGALVGSSGAYLSYIMCQAMNRSFISVIAGGFGIEAPAGEATDYGEHREVDAEGVAELLKDASSVVITPGYGMAVAQAQYPVADLTRKLRERGVDVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEVNDDLADTDVVLVIGANDTVNPAAAEDPTSPIAGMPVLRVWEASNVVVFKRSMAAGYAGVQNPLFFRENSQMLFGDAKDRVEDILRAL
>NZ_CP011502.1|WP_067860502.1|3224107_3224749_-|hypothetical-protein
MAFLLRVELPDVPGSLGALATALGGAGADIEAIEIVEHRADGKAVDDVLLELPPSVMADALVTACHELDGVRVHWISRYNAGANLSMDLEAVEQFTSEPQHAVERLVEVVPATFRTDWAMALRRVDGEASVLFASPSAPKLVPEAAEWLSIRSSSRLEGVEAWSSTLLAGTHAKDRQGRGFVVVVGRHGGPEFLASELARLGHMTSLAGSVQA
>NZ_CP011502.1|WP_067860504.1|3224862_3225210_+|DUF3817-domain-containing-protein
MRRWFRIFAFAEAVSWGALLVAMFFKWVVQDDPHAGLEGGVPIVGPIHGVLFLAYCSLAVVAWSTFRWNLKTLALALAASIPPFFTIWFETWAERRGLLTSVADDPDPAPGVTQV
>NZ_CP011502.1|WP_067860506.1|3225200_3226169_-|GGDEF-domain-containing-protein
MLRKVAELRRAVGWPAMTAATVLLSLTALCMLALTLATWQPDNNPRWVLYVLVVVALGGLAWTVRRGALLEPREVAAMVSLCFVALAVLTWGTERQVAVLANGTSTPTLAVFAVWFLPLALARVVSYVGTALWVLAVASHHDPQMLGPTVAVVVQVLVGTEVLGRLRLRLDRLARTDQLTGALNRWGVQAVVDAQLVRRRRLGTPLTVLALDVDDLRAVNTLGGHAAGDRLLTSVVEHLRAGLREGDVLGRLGGDEFLVVMPGADHGVADVVARRLQVGAPASWSCGVAQARADDDVASLLARADDRMYAQKQGRRPESGQT
>NZ_CP011502.1|WP_067860508.1|3226355_3226844_+|hypothetical-protein
MSLRKNKTVRDKVQERLEGRLDDLVAQADSVRQQLADRAPEVRDTVVAKAQSGVADLRERLPEIGHDLLDRAPELSEKTYDRLPKGVADRLPEEVKPKKKRRLRRVVGIGLLIGAGAAAFATLKGKQTPPPPPYQPATPPPAPPKPAAPADSLDSVDAPGTN
>NZ_CP011502.1|WP_067860510.1|3226943_3227786_+|Ku-protein
MRSLWKGSISFGLVNVPVRVYSATESHDVSLHQVHAEDGGRIRYQRRCEVCGEVVAYEDIAKAYDDGENTVVLTADDLASLPAESAKEIEVLEFVPAQQIDPIRLDKAYFLEPDKTAIKPYTLLRRALEDTDRSAVVRFALRQKSRLAVLRVRDKTLLLQTMLWDDEVRTADFDVLETVPRISAKERDMASQLVDSLAADFDASQFTDDYQEQLRTLVEAKLEQGDTIDTAATFGTSDDDGDDAEVVDLMEALKRSVERSKERRGQGGSTASKPRARKKA
>NZ_CP011502.1|WP_067860512.1|3227795_3230405_+|ATP-dependent-DNA-ligase
MPSRGSSSSQTVTIDGRRLRLTNPDKVLYPATGTTKAEVISYYVAVADRLLPHASGRPVTRKRWPDGVGAVGEAPGGGSGPRAEKAPGGGSGPRAEKAPGGGSGPRAEKSAELFFEKNLPDSAPDWVRRVVVRHKSHVNVYPLVDGPAALAWLGQVAALELHVPQWRVEADGTPRHPDRLVLDLDPGPGVGLAECVEVAHAARDLLADVGLEAFPVTSGSKGLHLYAHLTGEHDADYVNAFAKQVAAALQDELPDLVVSSMKKSLREGRVLVDWSQNNQAKTTIAPYSLRGRAAADGEGPFVAAPRSWDELGPDLRHLTMEEVLERDDDPLAGLDPQPTSGDEAPVAAPDRLTVYRSMRDASRTPEPVPAEAPTERGADPIFVVQEHHATRLHYDVRLEREGVLVSWAVPKGPPTDPSRNHLAVPTEDHPMEYATFEGTIPRGEYGAGQVSIWDHGTYTLEKWKEGEVIAVLHGSAGGGLGGSVRFALIRTGENWLMHRMDPPAAPDTAAADTAAADDGTAPTTTPTTDEPDGGGPPDAGRLETVAPMLASRPDGLDPHRDADAWAFEMKWDGVRVVATCDGGAVRLVGRSGKDVTTTYPEVAEALAGLHLDDAVVDGEVVALGDDGAPSFGRIQQRIGLVRPRDVAAARRAVPVRYVVFDLLRLGGTDVTGLPYVQRRELLEGLDLDDADRVDVPAAFDGDLDAALASSRELGLEGVVAKRRSSRYRPGSRSAHWVKLKHEDHVEVVVVGWRPGRGGRTGGVGSLLVAVPDAAGGLRYAGRVGTGFDERALADLARRLEPLRRDQPTVEAPRDVAREAVWTEAELVGEVTAAGWTDSGHLRHPVWRGLRADKTVADVEPVADPRPDPS
>NZ_CP011502.1|WP_083516490.1|3230459_3231923_+|glucose-6-phosphate-dehydrogenase
MRSPTVAPSVERDPVSLTPGRVVSSSSSLPPQVVVLFGATGDLAKRKLFPGLYRLALADRLPADYRVIGSGRHEPKKDFREQVMDGLKEFVDDLDVDVAERLVSRTSFQTSDADDGSDLAAAVRDAESELGGDARRLVYLSVPPAAMEPMIRMLGETGIADGARIVVEKPFGTDLESSRSLQATLDEVAGEDSVFRIDHFLGKEAVQNVLALRFANGLLEPSWDAEHVCAVQIDVPEELTIEGRGSFYEATGALRDMVSTHLSQVLGFLAMERPESIDADHLRDAKAAVFADLQPLRADDVVRGQYEGYRDEEGVDDDSEVETFVAVRVHVDNDRWRGVPFLLRTGKAMAATRRTATLFFRAPEPLFDERQDGDDRLVLELGEAPEVTAALHVKRPGPTFELTRASATFKLPDDDPEHRPLEAYERLLLDVMHGDQTLFTRGDEVDRLWQVITPVLEDPPPVQTYEKGSWGPQAALDLAGERGWHLR
>NZ_CP011502.1|WP_067860516.1|3231919_3233842_+|glycoside-hydrolase-family-15-protein
MTGSPPGPTSGPLPISDHGLVGDLRTAALVGTDGTIGWFCPGRFDAPSVFASVLDDERGGAWELEPVDGSVRSQQFYFPDTAILATRFLTDDGVVEVHDFMPVLRAEDPDHRQRLVRRVVAVRGRSVVRTRVAARPHYGRTTPDLELLDVASGHGVSLTCEGRGDDPGVRMAFGATVPLEVDAGDVTAEFTLEEGERALFVLEVLDPHADTPTDGCDDTDTSALFEATSQFWRSWLSQSTYAGRWRETVHRSAITLKLLTHEPSGAIVAAPTTSLPETIGGTRNWDYRYVWIRDAGFSLYALLRLGFTSEANAFTRWLSERLGEEREDEAELGPLRVLYDIDGSAPTDEHELDHLSGYRDSRPVRVGNAAVDQMQLDIYGEVIDAVYLFDKYGPGISHDAWNDLRRVLDWVLEHWDADDAGMWEIRGDVRAHTTSRLMCWVAVERMIRMARRRGLPGDVGAWSRVRDEIHERILSDHWDPHHETFLMAEADPDAAPDDDPVLDAGVLLMPMVKFCSPVDPRFLSTLAAVEEQLVADSLVFRYDVHAAPDGIEDADADGDGVGDGEGTFSLCSFWYVEALTRAGRLREAEVALEKMFTYANHLGLYAEQIGATGDQLGNFPQAFTHLSLISAAINLDRALA
>NZ_CP011502.1|WP_067860518.1|3234456_3235032_+|hypothetical-protein
MGTPTTTQAGSTARRLVAAVAVLVALAGCGAAGGPRYDIPHDAASGGQTLRQAQAAVSSIPGLTIDVAGGEPPNIKGNTGYDVRVTVAPGYRIVDGPALVTFLVESAWSVRTGYLPNTYITVSVDTGDGPEFDVDAAAAEGGWVERGEPVPGQTSFSLVNVRTDDGSPARERLGDWPGDVPAFPRGVTARR
>NZ_CP011502.1|WP_083516652.1|3235173_3237207_-|DEAD/DEAH-box-helicase
MPVLAKAVREVENAVQRRRVTASTRATFQAVGLLVREERARVKTATDLTEPQRADQLKRLDGVATILAKTATREPALLMLLTDDAEISSSTLALKRELMAAAGLELAVEPPAATTELRVDRSVVPRSVVARQLANPFMPPEFSPEPPPRTGPSRLATWELIGPLLSSFERAAAGAPACMELPEPLPLNHRGPDLMRHQAQLVSSAAEGHRTFLLADEPGLGKTAQSLLAAHAAQAYPLLVVVPNVVKANWAREVGLWTPQRAVTVVHGNGDDIDAFADIVVVNYEILDRHAGWLGDLGFRGMVLDEAHFIKNTSSQRSRHVLRIADRIRSRTARPLMMALTGTPLINDVEDFRAIWQFLGWIDEKKPLPELMHRLDETGLTPLDPGFFPAARQAVIDMGIVRRRKIDVAADIPARRIADMPVELDGEAGRSIRAAEAELARRLVARYDRAAAARVEAGHPVADVLDLDLVRKVAAWEREEANESTGENVFSMVRRIGQAKAGLAADYTAQLARSVGKVVFFAKHLDVMDAAQKAFEERGIGYSTIRGDQTAAARAKAIDAFQNDPGTQIIVCSLTAAGVGINLQVASNVVLAELSWTDAEQMQAIDRVHRIGQEEPVTAWRIIASQTIDTRIVELIDSKAGLAARALDGEDTEVDVTDVQLEALVGILSDSLRSRRR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP011502_16	16.1\|3108974\|35\|NZ_CP011502\|CRT	3108974-3109008	35	NZ_CP011502.1	3109112-3109146	2	0.943

1. spacer 16.1|3108974|35|NZ_CP011502|CRT matches to position: 3109112-3109146, mismatch: 2, identity: 0.943

acgcccggcgtgccctcggcgccaccgtcagcggg	CRISPR spacer
acacccggggtgccctcggcgccaccgtcagcggg	Protospacer
**.***** **************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP011502_16	16.2\|3109031\|23\|NZ_CP011502\|CRT	3109031-3109053	23	NC_016587	Azospirillum lipoferum 4B plasmid AZO_p4, complete sequence	452705-452727	2	0.913
NZ_CP011502_16	16.2\|3109031\|23\|NZ_CP011502\|CRT	3109031-3109053	23	MN693666	Marine virus AFVG_250M158, complete genome	24913-24935	3	0.87
NZ_CP011502_16	16.2\|3109031\|23\|NZ_CP011502\|CRT	3109031-3109053	23	NZ_CP021082	Deinococcus ficus strain CC-FR2-10 plasmid pDFI1, complete sequence	318786-318808	3	0.87
NZ_CP011502_16	16.2\|3109031\|23\|NZ_CP011502\|CRT	3109031-3109053	23	NZ_CP034351	Streptomyces sp. W1SF4 plasmid p1, complete sequence	232677-232699	4	0.826
NZ_CP011502_16	16.1\|3108974\|35\|NZ_CP011502\|CRT	3108974-3109008	35	NC_011044	Mycobacterium phage Nigel, complete genome	46026-46060	7	0.8
NZ_CP011502_10	10.1\|876433\|31\|NZ_CP011502\|CRISPRCasFinder	876433-876463	31	NC_017966	Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence	543341-543371	8	0.742
NZ_CP011502_10	10.1\|876433\|31\|NZ_CP011502\|CRISPRCasFinder	876433-876463	31	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	2510185-2510215	8	0.742
NZ_CP011502_10	10.1\|876433\|31\|NZ_CP011502\|CRISPRCasFinder	876433-876463	31	NZ_CP009112	Rhodococcus opacus strain 1CP plasmid pR1CP1, complete sequence	40288-40318	8	0.742
NZ_CP011502_10	10.1\|876433\|31\|NZ_CP011502\|CRISPRCasFinder	876433-876463	31	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	1117120-1117150	8	0.742
NZ_CP011502_10	10.1\|876433\|31\|NZ_CP011502\|CRISPRCasFinder	876433-876463	31	NC_013852	Allochromatium vinosum DSM 180 plasmid pALVIN01, complete sequence	12993-13023	8	0.742
NZ_CP011502_10	10.1\|876433\|31\|NZ_CP011502\|CRISPRCasFinder	876433-876463	31	MN234196	Gordonia phage CloverMinnie, complete genome	37663-37693	8	0.742
NZ_CP011502_10	10.1\|876433\|31\|NZ_CP011502\|CRISPRCasFinder	876433-876463	31	NZ_CP034352	Streptomyces sp. W1SF4 plasmid p2, complete sequence	112622-112652	9	0.71
NZ_CP011502_10	10.2\|876487\|34\|NZ_CP011502\|CRISPRCasFinder	876487-876520	34	NZ_CP021082	Deinococcus ficus strain CC-FR2-10 plasmid pDFI1, complete sequence	334213-334246	9	0.735
NZ_CP011502_16	16.1\|3108974\|35\|NZ_CP011502\|CRT	3108974-3109008	35	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	1626062-1626096	10	0.714
NZ_CP011502_16	16.1\|3108974\|35\|NZ_CP011502\|CRT	3108974-3109008	35	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	411617-411651	10	0.714

1. spacer 16.2|3109031|23|NZ_CP011502|CRT matches to NC_016587 (Azospirillum lipoferum 4B plasmid AZO_p4, complete sequence) position: , mismatch: 2, identity: 0.913

ccgccgtcctgcacgcccggcgt	CRISPR spacer
ccggcgtcctgcacgcccagcgt	Protospacer
*** **************.****

2. spacer 16.2|3109031|23|NZ_CP011502|CRT matches to MN693666 (Marine virus AFVG_250M158, complete genome) position: , mismatch: 3, identity: 0.87

ccgccgtcctgcacgcccggcgt	CRISPR spacer
gcgccgtcccgcacgcccggcgg	Protospacer
 ********.************

3. spacer 16.2|3109031|23|NZ_CP011502|CRT matches to NZ_CP021082 (Deinococcus ficus strain CC-FR2-10 plasmid pDFI1, complete sequence) position: , mismatch: 3, identity: 0.87

ccgccgtcctgcacgcccggcgt	CRISPR spacer
ccgccgtcctgcccgcccggcac	Protospacer
************ ********..

4. spacer 16.2|3109031|23|NZ_CP011502|CRT matches to NZ_CP034351 (Streptomyces sp. W1SF4 plasmid p1, complete sequence) position: , mismatch: 4, identity: 0.826

ccgccgtcctgcacgcccggcgt	CRISPR spacer
acgccgtcctgcacgcccggatc	Protospacer
 *******************  .

5. spacer 16.1|3108974|35|NZ_CP011502|CRT matches to NC_011044 (Mycobacterium phage Nigel, complete genome) position: , mismatch: 7, identity: 0.8

acgcccggcgtgccctcggcgccaccgtcagcggg	CRISPR spacer
accaccttcatgccctcgtcgccaccgtcaccggg	Protospacer
**  **  *.******** *********** ****

6. spacer 10.1|876433|31|NZ_CP011502|CRISPRCasFinder matches to NC_017966 (Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence) position: , mismatch: 8, identity: 0.742

ctcgggactcgacggggcggtggccgtgcgg	CRISPR spacer
gtcggggcttgacggggcggtggccggttcc	Protospacer
 *****.**.****************  .

7. spacer 10.1|876433|31|NZ_CP011502|CRISPRCasFinder matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.742

ctcgggactcgacggggcggtggccgtgcgg	CRISPR spacer
gccgggacacgaccgggcggtggccgcggcc	Protospacer
 .****** **** ************.*

8. spacer 10.1|876433|31|NZ_CP011502|CRISPRCasFinder matches to NZ_CP009112 (Rhodococcus opacus strain 1CP plasmid pR1CP1, complete sequence) position: , mismatch: 8, identity: 0.742

ctcgggactcgacggggcggtggccgtgcgg	CRISPR spacer
cgacggacccgacgaggcggtggccgtggcc	Protospacer
*   ****.*****.*************

9. spacer 10.1|876433|31|NZ_CP011502|CRISPRCasFinder matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 8, identity: 0.742

ctcgggactcgacggggcggtggccgtgcgg	CRISPR spacer
gccgggacacgaccgggcggtggccgcggcc	Protospacer
 .****** **** ************.*

10. spacer 10.1|876433|31|NZ_CP011502|CRISPRCasFinder matches to NC_013852 (Allochromatium vinosum DSM 180 plasmid pALVIN01, complete sequence) position: , mismatch: 8, identity: 0.742

ctcgggactcgacggggcggtggccgtgcgg	CRISPR spacer
atcgggactcggcggggcggtggtctcctcg	Protospacer
 **********.***********.* . . *

11. spacer 10.1|876433|31|NZ_CP011502|CRISPRCasFinder matches to MN234196 (Gordonia phage CloverMinnie, complete genome) position: , mismatch: 8, identity: 0.742

ctcgggactcgacggggcggtggccgtgcgg	CRISPR spacer
cagtgcgctcgacggcgcggtggccatgcgc	Protospacer
*   * .******** *********.****

12. spacer 10.1|876433|31|NZ_CP011502|CRISPRCasFinder matches to NZ_CP034352 (Streptomyces sp. W1SF4 plasmid p2, complete sequence) position: , mismatch: 9, identity: 0.71

ctcgggactcgacggggcggtggccgtgcgg	CRISPR spacer
tgggcagttccacggggcgggggccgtgcgg	Protospacer
.  * ...** ********* **********

13. spacer 10.2|876487|34|NZ_CP011502|CRISPRCasFinder matches to NZ_CP021082 (Deinococcus ficus strain CC-FR2-10 plasmid pDFI1, complete sequence) position: , mismatch: 9, identity: 0.735

cgagcggctgcgcacgcaggacctcaccgtccgc	CRISPR spacer
cgagcgccagcgcacgcaggacctgccgggtggt	Protospacer
****** * ***************  * * . *.

14. spacer 16.1|3108974|35|NZ_CP011502|CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 10, identity: 0.714

acgcccggcgtgccctcggcgccaccgtcagcggg	CRISPR spacer
acgcccggcatgacctcggcgccactgctgtgacg	Protospacer
*********.** ************.*...  . *

15. spacer 16.1|3108974|35|NZ_CP011502|CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 10, identity: 0.714

acgcccggcgtgccctcggcgccaccgtcagcggg	CRISPR spacer
acgcccggcatgacctcggcgccactgctgtgacg	Protospacer
*********.** ************.*...  . *

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage