CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP014857	Lysinibacillus sphaericus III(3)7 plasmid, complete sequence	2 crisprs	cas5,cas8c,cas7,RT	0	6	0	0
NZ_CP014856	Lysinibacillus sphaericus III(3)7, complete genome	1 crisprs	csa3,cas3,WYL,DEDDh,DinG,RT,c2c9_V-U4	0	0	8	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP014857_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014857_1

58815-59110

TypeI

I-C

Consensus_repeat	Method
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT	PILER-CR
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT	CRISPRCasFinder
GTCGCTCTCCTTAGNGGGAGCGTGGATTGAAAT	CRT

4 spacers

cas7,cas8c,cas5,RT

The CRISPR arrays of NZ_CP014857_1

>merge|NZ_CP014857|1|58815-59110|PILER-CR,CRISPRCasFinder,CRT
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAATATTAAAAAAAATCAAAGCAGAGGATAAGCTAACGGTCGCTCTCCTTAGGGGAGCGTGGATTGAAATTATATGGGCTGATAACATTTCATTAATTTGCTGCAGTCGCTCTCCTTAGGGGAGCGTGGATTGAAATATTACCATTTATATCTCTTATTATAAATCTTGCGTCGCTCTCCTTAGGGGAGCGTGGATTGAAATTGGTACATGCTTATAGGGTGTCTAGTTAGCTTTCGTCGCTCTCCAGGTGGAGGGCGTGGGTTGAAA

>NZ_CP014857|1|1|58815-59044|PILER-CR
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT	ATTAAAAAAAATCAAAGCAGAGGATAAGCTAACG
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT	TATATGGGCTGATAACATTTCATTAATTTGCTGCA
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT	ATTACCATTTATATCTCTTATTATAAATCTTGC
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT

>NZ_CP014857|1|1|58815-59044|CRISPRCasFinder
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT	ATTAAAAAAAATCAAAGCAGAGGATAAGCTAACG
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT	TATATGGGCTGATAACATTTCATTAATTTGCTGCA
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT	ATTACCATTTATATCTCTTATTATAAATCTTGC
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT

>NZ_CP014857|1|1|58815-59110|CRT
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT	ATTAAAAAAAATCAAAGCAGAGGATAAGCTAACG
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT	TATATGGGCTGATAACATTTCATTAATTTGCTGCA
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT	ATTACCATTTATATCTCTTATTATAAATCTTGC
GTCGCTCTCCTTAGGGGAGCGTGGATTGAAAT	TGGTACATGCTTATAGGGTGTCTAGTTAGCTTTC
GTCGCTCTCCAGGTGGAGGGCGTGGGTTGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014857.1\|WP_061504570.1\|64325_64742_+\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|372305
NZ_CP014857.1\|WP_012291762.1\|51643_51901_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291756.1\|55232_55961_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	gnl\|CDD\|187782
NZ_CP014857.1\|WP_041659309.1\|51960_52212_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_061504572.1\|63542_63722_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291755.1\|55976_57797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	pfam09709_cas8c_CAS-I-C	gnl\|CDD\|187887
NZ_CP014857.1\|WP_145912398.1\|50512_51475_+\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|235511
NZ_CP014857.1\|WP_012291754.1\|57789_58647_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|187820
NZ_CP014857.1\|WP_041659307.1\|52427_53285_+\|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl\|CDD\|238192
NZ_CP014857.1\|WP_155726289.1\|63285_63435_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_061504568.1\|65569_65782_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291758.1\|54101_54437_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_061504566.1\|66401_66767_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291753.1\|59871_60036_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291757.1\|54452_54953_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291752.1\|60794_62600_+\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209
NZ_CP014857.1\|WP_061504569.1\|65151_65340_+\|DUF3797-domain-containing-protein	unknown	unknown	gnl\|CDD\|289447
NZ_CP014857.1\|WP_061504573.1\|62726_63212_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291759.1\|53320_54061_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_061504567.1\|65932_66328_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP014857.1\|WP_061504570.1\|64325_64742_+\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|372305	pfam12773, DZR, Double zinc ribbon. This family consists of a pair of zinc ribbon domains.	0.000189377
NZ_CP014857.1\|WP_012291752.1\|60794_62600_+\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	1.22524e-124
NZ_CP014857.1\|WP_012291756.1\|55232_55961_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187782	cd09651, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	2.64406e-72
NZ_CP014857.1\|WP_041659307.1\|52427_53285_+\|DNA-(cytosine-5-)-methyltransferase	gnl\|CDD\|238192	cd00315, Cyt_C5_DNA_methylase, Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.	8.41566e-54
NZ_CP014857.1\|WP_012291755.1\|55976_57797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	1.58415e-125
NZ_CP014857.1\|WP_145912398.1\|50512_51475_+\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|235511	PRK05574, holA, DNA polymerase III subunit delta; Reviewed.	9.38561e-51
NZ_CP014857.1\|WP_012291754.1\|57789_58647_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|187820	cd09689, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csd2 family.	1.64382e-110
NZ_CP014857.1\|WP_061504569.1\|65151_65340_+\|DUF3797-domain-containing-protein	gnl\|CDD\|289447	pfam12677, DUF3797, Domain of unknown function (DUF3797). This presumed domain is functionally uncharacterized. This domain family is found in bacteria and viruses, and is approximately 50 amino acids in length. There is a conserved CGN sequence motif.	1.29802e-05

>NZ_CP014857.1|WP_012291754.1|57789_58647_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MTKNEIKAINKKDFAIVFSVKNANPNGDPNNGNRPRQSPFDSIGEISDVAIKRKIRNRFMDYDQDIFVQSEDRTIDGFRSLKDRADSIEGLKGADSETYKKIACETWIDVRTFGQVFSFKGDKNDSVSVGVRGPVAIQSAFSVHPIEITSTKITKSVNLVTSNKKTSDTMGEKHRVNYGLYVCYGSINSQLAQDTKFSDKDAALLKEILSSIFENDLSAARPSGSMEVHNVYWWEHNSPLGQYSSAKVHRSLEIKQTVESPTSYDDFEIKVNELDGLSVEVLPGY
>NZ_CP014857.1|WP_012291755.1|55976_57797_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSLLNALVQTYDNNLEVVGKVNKKRNGTEYTLLPIAHSTQVTHVEVFVSNQGEFLSAAVIEGERNTVIPVTEASSGRTSGLAPHPIHDKLMYVAGDYSDYISGKSKAREAFKLYLEQLSKWCDSEYGHESLSNLYEYLKKGTLIEDLVKNKTLYLDDNGMLLLKWQKKNEKTPDIYKIVSNVADVAIRFTIEGLEPVMWENTDIRNLHIQKTISDITELDFCYVTGEYAPISVNQPKKIRNTMDQAKLISSSNANALTFKGRFAEARDSFNISYEASQKAHNALKWLINRQSINIDGRVFLVWSDGMEQPKNWDELLRAGEQEAKEFYLNLTGVKEGHIDSKNTYLTILDAATPGRLAVTSFEQLTTSSYYKRVYNFYNKYIWYFTHRKNDNGENQEGLAAPTLKEILNVIYPDTTRADILKNTYNTLLICVLYNRPIPREYINRAVARLKNGNEMGTWEWDKNLSITCALINYERGKGEFSVSLDTQNNNRSYLFGRLLAVAEVLERSALGSENRPTNAARYTASFVQAPARTWTILQQKIVPYQNKLNSKLAAYYQAIIDNIISLMNPNDFSNKTLEETYLLGFYSQRKDLYTKKEKKGDKSND
>NZ_CP014857.1|WP_012291756.1|55232_55961_+|type-I-C-CRISPR-associated-protein-Cas5
MAWTIEFLVYGRNALFTDPFSKTGGEKTTTLIPTYEAMKGVAESIYWKPSIKWHIDSIRVMKAIRTESKGVLPRVYSGGKMLSLYTYLHDVAYQVRATISPNESRPDLKNDYNMVKHHQMALRSLDKGGRRDIFLGVRECQAYVEPCKFGSEDGEYDSTGTIGFGLMVHGFNYPNNRSKLFEVRFWKPEMLNGIINFPKPSDCIYTRKIREMNVKQGARFQSVDDALDILIREDGLGFFNNI
>NZ_CP014857.1|WP_012291757.1|54452_54953_+|hypothetical-protein
MKNEYVGIKEIAEIGASIEFEKDGQILDLAVYEVFEDHVVVTGGINVQHKDYTITAYDLQERKMRELPRVNLLFTEQEVGKEMMEKFIITQKDNDFAEIGHCFRCKFDGEKVTIHNDMSWWSVTIPLEQFRNEFKEMSKEDYSTYINACNEGEDQVIESVIKKYLG
>NZ_CP014857.1|WP_012291758.1|54101_54437_+|hypothetical-protein
MNKWNNFETLEHHKGKIWVSKLFKLENRGNICYLQNGEFLMLAYVSPSMLENKLLDTVIKDIIIANGTPYMLSEDTITCSVCGNSYDEGDVNIVDYPDDVCVTCEKNYTGS
>NZ_CP014857.1|WP_012291759.1|53320_54061_+|hypothetical-protein
MKSTHEIIAEAAKQLKLGVFNRVAVREESWALDKEKYYNRHLDDNEYIEIITFYNNKRNKTGNFIESLHVYFRWSLDDINVCAYTTSENQSVYQGTKIRNLKNPTKIGEVTTTFKDIAAVLKQFVLDAQKVLNIYLNKKIDPQFEATVKLLVETYSDKSNNLECMTVHFAIHSPSVSINLETGWGGDDFFFTVSKDRKKASMKIKLDAFELAPGDRTTYIETVDINEGDFLTAYKKFFYDYHLITQ
>NZ_CP014857.1|WP_041659307.1|52427_53285_+|DNA-(cytosine-5-)-methyltransferase
MITAKSYFSGAGGLDLGIIEAGIDVIESFEIDKKACNTLRNNFKHIINETDITKITVLDQQDADVYIGTFPCTKYSNIADIHGTRTGDDLFLHFFRHVALAQPEAYVIENVPGMKKFQVVMECLTKLPNYYVRVECPVNANMWLPQERKRLIVIGTKRPFNNLDYPESTPIKMRDIIDVGTEVYTPKYVQKRLEGHYRDKPIITDLDGIAPTCVAHYSKDRSTRLINDGVKIRPYSVREWARLQGFPDWFKFDGTDNDAYKMIGNAVPVNMGLWVGKQLKKYFAG
>NZ_CP014857.1|WP_041659309.1|51960_52212_+|hypothetical-protein
MLILNDNKTIESIFEGYDEWLLIGNEPQRKDVDEYTERYDLAGNRTCLYCSSRLPEDHPLTVCDSCYPDEDQTIESDLEGYDE
>NZ_CP014857.1|WP_012291762.1|51643_51901_+|hypothetical-protein
MNLKTAANWKWSLHQYLQVGDIVDDEIYSHFVNVLPPATFKQSLVQMGEPYCHVEGQPTYPTLQKTEHGWKYMGNCFRGEVVNKD
>NZ_CP014857.1|WP_145912398.1|50512_51475_+|DNA-polymerase-III-subunit-delta
MYNSCKGGTILIHLLFGTEDFLIAEKKKEICRVEGVSISSFDMRETSLTSALEDAQMSDLFGGKKIVFLNDSYFLTGDTSKKITHDTDALLDYLESPNPDSTVVLVVNNEKLDKRKKVVKELLQKATTTFEAKPLYNAEKWLVERCKVYGKTLTRQAAVIMQQQLGKDLFLLDTELTKLVLAVDNPTISEKDLEGVLSRTLEGDVFKIVDHVIYKRSEALEILDDLFRLGHDSIQILLILAGQFRLIHQVKAIHELGESPKNILKGIHPYRLSMAEEQCQLYSIEDLQQRLKDCAELDLQMKRGYCDKVIGLETLILKWL
>NZ_CP014857.1|WP_012291753.1|59871_60036_+|hypothetical-protein
MTLGKASEIKFALIASNGRQQLQEWLEENRDVEVLDIKFDFDNYPKFLVIYRDN
>NZ_CP014857.1|WP_012291752.1|60794_62600_+|group-II-intron-reverse-transcriptase/maturase
MSTTLRHAEYYDMQSIFDDLYERSKNNATKGLNLYEHIISKNNILLAYRNIKANTGSKTAGTDGITIEQYKIEDVETFVDEIRATLKNYKPQTVRRVEIPKPNGKTRPLGIPTMRDRLIQQMFKQILEPICEARFYNHSYGFRPNRSTHHAMGRCQFLANIALNQHVVDIDIQGFFDNVSHSKLLKQMYSIGICDKRVLSVVSKMLKAPIKGIGIPTKGTPQGGILSPLLSNIVLNDLDWWISNQWENMKTKFNYKERKNKVLMIKRTTTLKEMYIVRYADDFKIFTKSHKNAIKLYHAVKGYLKNHLNLDISNEKSKITNLRKRASEFLGFSLKVIKKGKRYVANTHVMDDKVKTILQKARKLIHEIKKNPTAKMAMNYNAYVLGIKNYYKIATHVNTDFSEIAYRLSRTLYNRLKSIGNYGIPIKPSETYKRFNKNNFKTFEIENIHLFPIADIKTVNSTNFSQDLCNYTKEGRLKLHKQLKNDVAIEINRLLKTISYNDNLEYADNRISRYSMQSGKCAITGDFLVAEEVHCHHRIPRYMGGSDEFKNLVIVHSNVHKLIHATETETIERYKSLLQLDGKQLEKLNQFRKKCNLVALV
>NZ_CP014857.1|WP_061504573.1|62726_63212_+|hypothetical-protein
MGMYTAFRGKVIIKEQYKELVELINSGEWGIAVNKYPFLKEFYEIQRSTIIPYDIERIRKQLDKDGEIYLEHDPSDWASDSTYFTGLNGLEWTFITSLKDYPDREHGNKSPIVTFIDVVLSEVTSKVITIQEAYEEWIYNDIPFVEYDFDKVVINKITIKI
>NZ_CP014857.1|WP_155726289.1|63285_63435_+|hypothetical-protein
MSIHEAEWIVSEYEKGEKRFSNETVHKAYNLLEASPYEKYECDFVILNG
>NZ_CP014857.1|WP_061504572.1|63542_63722_+|hypothetical-protein
MRAVTMVLSISALIFTLWIIFFVDINSFEEVKQLSYNWIAFVVLVLMFFGGIFYSLKRK
>NZ_CP014857.1|WP_061504570.1|64325_64742_+|zinc-ribbon-domain-containing-protein
MFKTQLSRYCPNCQRIKHEPQAAFCFLCGTALKNGSLLEFYQTLKIPFAKIQIEKRYSEKYTSSAFPFFLWKHDRINKTIEVVTFHEYPKGVRLYVKLPARSSQANSSEEILLKEGTLDKLLKEGFEWFHQTEKETLW
>NZ_CP014857.1|WP_061504569.1|65151_65340_+|DUF3797-domain-containing-protein
MPLLFSEISPIKIFFFILKHKKCHECGSTLVGNGEGHFELTEKGFKRECKCGASVQTGFCKS
>NZ_CP014857.1|WP_061504568.1|65569_65782_-|hypothetical-protein
MNKTWEPLLCGNERLVHDAMFSMKKRGGTITAITSFHRKFNKNSVIVAVQGLEAKGLVKYDNLSQEYTLV
>NZ_CP014857.1|WP_061504567.1|65932_66328_-|hypothetical-protein
MSVVYRGLISPLYEEPVYFSERGIPLLSQYFEDVNENELMKPLLTMENYEKWYSMYIIYPDGKVEKFSSSTKENCDTWYDHAVYPSYFHLIAKRLGCTYDNRTFALVCERFVEDVLDGDWTALHNYLPKER
>NZ_CP014857.1|WP_061504566.1|66401_66767_-|hypothetical-protein
MGYDISLYKIPTKLKEQHINEDELFEIVYGDVYGEDDEEYLLAYTNFSMGNPKSSDFAEVFNIFLTNNDYFKIYKMSDYYEAKRRLQSMELDDGLLERINKFLNVIEDELNKGEMIFFCCG

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Crispr_ID: NZ_CP014857_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014857_2

59516-59661

TypeI

Consensus_repeat	Method
GAGGGCGTGGGTTGAAAT	PILER-CR

2 spacers

cas7,cas8c,cas5,RT

The CRISPR arrays of NZ_CP014857_2

>merge|NZ_CP014857|2|59516-59661|PILER-CR
GCGTGGGTTGAAATTCAGATTACTAGGAGATTTAAGAATAAAGTATTGTCGCTCTGTGCTCAGAGGGTGTGGATTGAAACATCGATGGGAAACGTGCTGGCCTTTTTAGTTTAAGTCGCTCTCTATTTGAGGGCGCGGGTTGAAAT

>NZ_CP014857|2|2|59516-59661|PILER-CR
GCGTGGGTTGAAATTCAG	ATTACTAGGAGATTTAAGAATAAAGTATTGTCGCTCTGTGCTCAGAGG
GTGTGGATTGAAACATCG	ATGGGAAACGTGCTGGCCTTTTTAGTTTAAGTCGCTCTCTATTTGAGG
GCGCGGGTTGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014857.1\|WP_061504570.1\|64325_64742_+\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|372305
NZ_CP014857.1\|WP_012291762.1\|51643_51901_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291756.1\|55232_55961_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	gnl\|CDD\|187782
NZ_CP014857.1\|WP_041659309.1\|51960_52212_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_061504572.1\|63542_63722_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291755.1\|55976_57797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	pfam09709_cas8c_CAS-I-C	gnl\|CDD\|187887
NZ_CP014857.1\|WP_145912398.1\|50512_51475_+\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|235511
NZ_CP014857.1\|WP_012291754.1\|57789_58647_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|187820
NZ_CP014857.1\|WP_041659307.1\|52427_53285_+\|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl\|CDD\|238192
NZ_CP014857.1\|WP_155726289.1\|63285_63435_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_061504568.1\|65569_65782_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291758.1\|54101_54437_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_061504566.1\|66401_66767_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291753.1\|59871_60036_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291757.1\|54452_54953_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291752.1\|60794_62600_+\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209
NZ_CP014857.1\|WP_061504569.1\|65151_65340_+\|DUF3797-domain-containing-protein	unknown	unknown	gnl\|CDD\|289447
NZ_CP014857.1\|WP_061504573.1\|62726_63212_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_012291759.1\|53320_54061_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014857.1\|WP_061504567.1\|65932_66328_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP014857.1\|WP_061504570.1\|64325_64742_+\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|372305	pfam12773, DZR, Double zinc ribbon. This family consists of a pair of zinc ribbon domains.	0.000189377
NZ_CP014857.1\|WP_012291752.1\|60794_62600_+\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	1.22524e-124
NZ_CP014857.1\|WP_012291756.1\|55232_55961_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187782	cd09651, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	2.64406e-72
NZ_CP014857.1\|WP_041659307.1\|52427_53285_+\|DNA-(cytosine-5-)-methyltransferase	gnl\|CDD\|238192	cd00315, Cyt_C5_DNA_methylase, Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.	8.41566e-54
NZ_CP014857.1\|WP_012291755.1\|55976_57797_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	1.58415e-125
NZ_CP014857.1\|WP_145912398.1\|50512_51475_+\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|235511	PRK05574, holA, DNA polymerase III subunit delta; Reviewed.	9.38561e-51
NZ_CP014857.1\|WP_012291754.1\|57789_58647_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|187820	cd09689, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csd2 family.	1.64382e-110
NZ_CP014857.1\|WP_061504569.1\|65151_65340_+\|DUF3797-domain-containing-protein	gnl\|CDD\|289447	pfam12677, DUF3797, Domain of unknown function (DUF3797). This presumed domain is functionally uncharacterized. This domain family is found in bacteria and viruses, and is approximately 50 amino acids in length. There is a conserved CGN sequence motif.	1.29802e-05

>NZ_CP014857.1|WP_012291754.1|57789_58647_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MTKNEIKAINKKDFAIVFSVKNANPNGDPNNGNRPRQSPFDSIGEISDVAIKRKIRNRFMDYDQDIFVQSEDRTIDGFRSLKDRADSIEGLKGADSETYKKIACETWIDVRTFGQVFSFKGDKNDSVSVGVRGPVAIQSAFSVHPIEITSTKITKSVNLVTSNKKTSDTMGEKHRVNYGLYVCYGSINSQLAQDTKFSDKDAALLKEILSSIFENDLSAARPSGSMEVHNVYWWEHNSPLGQYSSAKVHRSLEIKQTVESPTSYDDFEIKVNELDGLSVEVLPGY
>NZ_CP014857.1|WP_012291755.1|55976_57797_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MSLLNALVQTYDNNLEVVGKVNKKRNGTEYTLLPIAHSTQVTHVEVFVSNQGEFLSAAVIEGERNTVIPVTEASSGRTSGLAPHPIHDKLMYVAGDYSDYISGKSKAREAFKLYLEQLSKWCDSEYGHESLSNLYEYLKKGTLIEDLVKNKTLYLDDNGMLLLKWQKKNEKTPDIYKIVSNVADVAIRFTIEGLEPVMWENTDIRNLHIQKTISDITELDFCYVTGEYAPISVNQPKKIRNTMDQAKLISSSNANALTFKGRFAEARDSFNISYEASQKAHNALKWLINRQSINIDGRVFLVWSDGMEQPKNWDELLRAGEQEAKEFYLNLTGVKEGHIDSKNTYLTILDAATPGRLAVTSFEQLTTSSYYKRVYNFYNKYIWYFTHRKNDNGENQEGLAAPTLKEILNVIYPDTTRADILKNTYNTLLICVLYNRPIPREYINRAVARLKNGNEMGTWEWDKNLSITCALINYERGKGEFSVSLDTQNNNRSYLFGRLLAVAEVLERSALGSENRPTNAARYTASFVQAPARTWTILQQKIVPYQNKLNSKLAAYYQAIIDNIISLMNPNDFSNKTLEETYLLGFYSQRKDLYTKKEKKGDKSND
>NZ_CP014857.1|WP_012291756.1|55232_55961_+|type-I-C-CRISPR-associated-protein-Cas5
MAWTIEFLVYGRNALFTDPFSKTGGEKTTTLIPTYEAMKGVAESIYWKPSIKWHIDSIRVMKAIRTESKGVLPRVYSGGKMLSLYTYLHDVAYQVRATISPNESRPDLKNDYNMVKHHQMALRSLDKGGRRDIFLGVRECQAYVEPCKFGSEDGEYDSTGTIGFGLMVHGFNYPNNRSKLFEVRFWKPEMLNGIINFPKPSDCIYTRKIREMNVKQGARFQSVDDALDILIREDGLGFFNNI
>NZ_CP014857.1|WP_012291757.1|54452_54953_+|hypothetical-protein
MKNEYVGIKEIAEIGASIEFEKDGQILDLAVYEVFEDHVVVTGGINVQHKDYTITAYDLQERKMRELPRVNLLFTEQEVGKEMMEKFIITQKDNDFAEIGHCFRCKFDGEKVTIHNDMSWWSVTIPLEQFRNEFKEMSKEDYSTYINACNEGEDQVIESVIKKYLG
>NZ_CP014857.1|WP_012291758.1|54101_54437_+|hypothetical-protein
MNKWNNFETLEHHKGKIWVSKLFKLENRGNICYLQNGEFLMLAYVSPSMLENKLLDTVIKDIIIANGTPYMLSEDTITCSVCGNSYDEGDVNIVDYPDDVCVTCEKNYTGS
>NZ_CP014857.1|WP_012291759.1|53320_54061_+|hypothetical-protein
MKSTHEIIAEAAKQLKLGVFNRVAVREESWALDKEKYYNRHLDDNEYIEIITFYNNKRNKTGNFIESLHVYFRWSLDDINVCAYTTSENQSVYQGTKIRNLKNPTKIGEVTTTFKDIAAVLKQFVLDAQKVLNIYLNKKIDPQFEATVKLLVETYSDKSNNLECMTVHFAIHSPSVSINLETGWGGDDFFFTVSKDRKKASMKIKLDAFELAPGDRTTYIETVDINEGDFLTAYKKFFYDYHLITQ
>NZ_CP014857.1|WP_041659307.1|52427_53285_+|DNA-(cytosine-5-)-methyltransferase
MITAKSYFSGAGGLDLGIIEAGIDVIESFEIDKKACNTLRNNFKHIINETDITKITVLDQQDADVYIGTFPCTKYSNIADIHGTRTGDDLFLHFFRHVALAQPEAYVIENVPGMKKFQVVMECLTKLPNYYVRVECPVNANMWLPQERKRLIVIGTKRPFNNLDYPESTPIKMRDIIDVGTEVYTPKYVQKRLEGHYRDKPIITDLDGIAPTCVAHYSKDRSTRLINDGVKIRPYSVREWARLQGFPDWFKFDGTDNDAYKMIGNAVPVNMGLWVGKQLKKYFAG
>NZ_CP014857.1|WP_041659309.1|51960_52212_+|hypothetical-protein
MLILNDNKTIESIFEGYDEWLLIGNEPQRKDVDEYTERYDLAGNRTCLYCSSRLPEDHPLTVCDSCYPDEDQTIESDLEGYDE
>NZ_CP014857.1|WP_012291762.1|51643_51901_+|hypothetical-protein
MNLKTAANWKWSLHQYLQVGDIVDDEIYSHFVNVLPPATFKQSLVQMGEPYCHVEGQPTYPTLQKTEHGWKYMGNCFRGEVVNKD
>NZ_CP014857.1|WP_145912398.1|50512_51475_+|DNA-polymerase-III-subunit-delta
MYNSCKGGTILIHLLFGTEDFLIAEKKKEICRVEGVSISSFDMRETSLTSALEDAQMSDLFGGKKIVFLNDSYFLTGDTSKKITHDTDALLDYLESPNPDSTVVLVVNNEKLDKRKKVVKELLQKATTTFEAKPLYNAEKWLVERCKVYGKTLTRQAAVIMQQQLGKDLFLLDTELTKLVLAVDNPTISEKDLEGVLSRTLEGDVFKIVDHVIYKRSEALEILDDLFRLGHDSIQILLILAGQFRLIHQVKAIHELGESPKNILKGIHPYRLSMAEEQCQLYSIEDLQQRLKDCAELDLQMKRGYCDKVIGLETLILKWL
>NZ_CP014857.1|WP_012291753.1|59871_60036_+|hypothetical-protein
MTLGKASEIKFALIASNGRQQLQEWLEENRDVEVLDIKFDFDNYPKFLVIYRDN
>NZ_CP014857.1|WP_012291752.1|60794_62600_+|group-II-intron-reverse-transcriptase/maturase
MSTTLRHAEYYDMQSIFDDLYERSKNNATKGLNLYEHIISKNNILLAYRNIKANTGSKTAGTDGITIEQYKIEDVETFVDEIRATLKNYKPQTVRRVEIPKPNGKTRPLGIPTMRDRLIQQMFKQILEPICEARFYNHSYGFRPNRSTHHAMGRCQFLANIALNQHVVDIDIQGFFDNVSHSKLLKQMYSIGICDKRVLSVVSKMLKAPIKGIGIPTKGTPQGGILSPLLSNIVLNDLDWWISNQWENMKTKFNYKERKNKVLMIKRTTTLKEMYIVRYADDFKIFTKSHKNAIKLYHAVKGYLKNHLNLDISNEKSKITNLRKRASEFLGFSLKVIKKGKRYVANTHVMDDKVKTILQKARKLIHEIKKNPTAKMAMNYNAYVLGIKNYYKIATHVNTDFSEIAYRLSRTLYNRLKSIGNYGIPIKPSETYKRFNKNNFKTFEIENIHLFPIADIKTVNSTNFSQDLCNYTKEGRLKLHKQLKNDVAIEINRLLKTISYNDNLEYADNRISRYSMQSGKCAITGDFLVAEEVHCHHRIPRYMGGSDEFKNLVIVHSNVHKLIHATETETIERYKSLLQLDGKQLEKLNQFRKKCNLVALV
>NZ_CP014857.1|WP_061504573.1|62726_63212_+|hypothetical-protein
MGMYTAFRGKVIIKEQYKELVELINSGEWGIAVNKYPFLKEFYEIQRSTIIPYDIERIRKQLDKDGEIYLEHDPSDWASDSTYFTGLNGLEWTFITSLKDYPDREHGNKSPIVTFIDVVLSEVTSKVITIQEAYEEWIYNDIPFVEYDFDKVVINKITIKI
>NZ_CP014857.1|WP_155726289.1|63285_63435_+|hypothetical-protein
MSIHEAEWIVSEYEKGEKRFSNETVHKAYNLLEASPYEKYECDFVILNG
>NZ_CP014857.1|WP_061504572.1|63542_63722_+|hypothetical-protein
MRAVTMVLSISALIFTLWIIFFVDINSFEEVKQLSYNWIAFVVLVLMFFGGIFYSLKRK
>NZ_CP014857.1|WP_061504570.1|64325_64742_+|zinc-ribbon-domain-containing-protein
MFKTQLSRYCPNCQRIKHEPQAAFCFLCGTALKNGSLLEFYQTLKIPFAKIQIEKRYSEKYTSSAFPFFLWKHDRINKTIEVVTFHEYPKGVRLYVKLPARSSQANSSEEILLKEGTLDKLLKEGFEWFHQTEKETLW
>NZ_CP014857.1|WP_061504569.1|65151_65340_+|DUF3797-domain-containing-protein
MPLLFSEISPIKIFFFILKHKKCHECGSTLVGNGEGHFELTEKGFKRECKCGASVQTGFCKS
>NZ_CP014857.1|WP_061504568.1|65569_65782_-|hypothetical-protein
MNKTWEPLLCGNERLVHDAMFSMKKRGGTITAITSFHRKFNKNSVIVAVQGLEAKGLVKYDNLSQEYTLV
>NZ_CP014857.1|WP_061504567.1|65932_66328_-|hypothetical-protein
MSVVYRGLISPLYEEPVYFSERGIPLLSQYFEDVNENELMKPLLTMENYEKWYSMYIIYPDGKVEKFSSSTKENCDTWYDHAVYPSYFHLIAKRLGCTYDNRTFALVCERFVEDVLDGDWTALHNYLPKER
>NZ_CP014857.1|WP_061504566.1|66401_66767_-|hypothetical-protein
MGYDISLYKIPTKLKEQHINEDELFEIVYGDVYGEDDEEYLLAYTNFSMGNPKSSDFAEVFNIFLTNNDYFKIYKMSDYYEAKRRLQSMELDDGLLERINKFLNVIEDELNKGEMIFFCCG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP014857_1	1.1\|58847\|34\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58847-58880	34	NC_010381	Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence	105108-105141	0	1.0
NZ_CP014857_1	1.1\|58847\|34\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58847-58880	34	NZ_CP014644	Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence	40395-40428	0	1.0
NZ_CP014857_1	1.1\|58847\|34\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58847-58880	34	NZ_CP014857	Lysinibacillus sphaericus III(3)7 plasmid, complete sequence	58847-58880	0	1.0
NZ_CP014857_1	1.2\|58913\|35\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58913-58947	35	NC_010381	Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence	105041-105075	0	1.0
NZ_CP014857_1	1.2\|58913\|35\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58913-58947	35	MT075580	Lysinibacillus sphaericus strain SSII-1 plasmid pSSII-1, complete sequence	10228-10262	0	1.0
NZ_CP014857_1	1.2\|58913\|35\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58913-58947	35	NZ_CP014644	Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence	40328-40362	0	1.0
NZ_CP014857_1	1.2\|58913\|35\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58913-58947	35	NZ_CP014857	Lysinibacillus sphaericus III(3)7 plasmid, complete sequence	58913-58947	0	1.0
NZ_CP014857_1	1.3\|58980\|33\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58980-59012	33	NC_010381	Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence	104976-105008	0	1.0
NZ_CP014857_1	1.3\|58980\|33\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58980-59012	33	MT075580	Lysinibacillus sphaericus strain SSII-1 plasmid pSSII-1, complete sequence	10163-10195	0	1.0
NZ_CP014857_1	1.3\|58980\|33\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58980-59012	33	NZ_CP014644	Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence	40263-40295	0	1.0
NZ_CP014857_1	1.3\|58980\|33\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58980-59012	33	NZ_CP014857	Lysinibacillus sphaericus III(3)7 plasmid, complete sequence	58980-59012	0	1.0
NZ_CP014857_1	1.4\|59045\|34\|NZ_CP014857\|CRT	59045-59078	34	NZ_CP014857	Lysinibacillus sphaericus III(3)7 plasmid, complete sequence	59045-59078	0	1.0
NZ_CP014857_1	1.4\|59045\|34\|NZ_CP014857\|CRT	59045-59078	34	NC_010381	Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence	104910-104943	0	1.0
NZ_CP014857_1	1.4\|59045\|34\|NZ_CP014857\|CRT	59045-59078	34	NZ_CP014644	Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence	40197-40230	0	1.0
NZ_CP014857_2	2.1\|59534\|48\|NZ_CP014857\|PILER-CR	59534-59581	48	NZ_CP014857	Lysinibacillus sphaericus III(3)7 plasmid, complete sequence	59530-59577	0	1.0
NZ_CP014857_2	2.1\|59534\|48\|NZ_CP014857\|PILER-CR	59534-59581	48	NC_010381	Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence	104411-104458	0	1.0
NZ_CP014857_2	2.1\|59534\|48\|NZ_CP014857\|PILER-CR	59534-59581	48	MT075580	Lysinibacillus sphaericus strain SSII-1 plasmid pSSII-1, complete sequence	9665-9712	0	1.0
NZ_CP014857_2	2.1\|59534\|48\|NZ_CP014857\|PILER-CR	59534-59581	48	NZ_CP014644	Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence	39698-39745	0	1.0
NZ_CP014857_2	2.2\|59600\|48\|NZ_CP014857\|PILER-CR	59600-59647	48	NZ_CP014857	Lysinibacillus sphaericus III(3)7 plasmid, complete sequence	59596-59643	0	1.0
NZ_CP014857_2	2.2\|59600\|48\|NZ_CP014857\|PILER-CR	59600-59647	48	NC_010381	Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence	104345-104392	0	1.0
NZ_CP014857_2	2.2\|59600\|48\|NZ_CP014857\|PILER-CR	59600-59647	48	MT075580	Lysinibacillus sphaericus strain SSII-1 plasmid pSSII-1, complete sequence	9599-9646	0	1.0
NZ_CP014857_2	2.2\|59600\|48\|NZ_CP014857\|PILER-CR	59600-59647	48	NZ_CP014644	Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence	39632-39679	0	1.0
NZ_CP014857_1	1.1\|58847\|34\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58847-58880	34	NC_019325	Vibrio anguillarum plasmid pJV, complete sequence	816-849	3	0.912
NZ_CP014857_1	1.3\|58980\|33\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58980-59012	33	NZ_CP033246	Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence	201110-201142	7	0.788
NZ_CP014857_1	1.3\|58980\|33\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58980-59012	33	NZ_CP033248	Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence	201150-201182	7	0.788
NZ_CP014857_1	1.1\|58847\|34\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58847-58880	34	NC_012219	Clostridium botulinum plasmid pC2C203U28 DNA, complete sequence, serotype: type C, strain: (C)-203U28	95653-95686	8	0.765
NZ_CP014857_1	1.1\|58847\|34\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58847-58880	34	NZ_CP029459	Clostridium novyi strain 150557 plasmid pCN1, complete sequence	4718-4751	8	0.765
NZ_CP014857_1	1.1\|58847\|34\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58847-58880	34	NZ_CP029459	Clostridium novyi strain 150557 plasmid pCN1, complete sequence	124551-124584	8	0.765
NZ_CP014857_1	1.3\|58980\|33\|NZ_CP014857\|PILER-CR,CRISPRCasFinder,CRT	58980-59012	33	MN693262	Marine virus AFVG_25M29, complete genome	34438-34470	8	0.758

1. spacer 1.1|58847|34|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NC_010381 (Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence) position: , mismatch: 0, identity: 1.0

attaaaaaaaatcaaagcagaggataagctaacg	CRISPR spacer
attaaaaaaaatcaaagcagaggataagctaacg	Protospacer
**********************************

2. spacer 1.1|58847|34|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014644 (Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

attaaaaaaaatcaaagcagaggataagctaacg	CRISPR spacer
attaaaaaaaatcaaagcagaggataagctaacg	Protospacer
**********************************

3. spacer 1.1|58847|34|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014857 (Lysinibacillus sphaericus III(3)7 plasmid, complete sequence) position: , mismatch: 0, identity: 1.0

attaaaaaaaatcaaagcagaggataagctaacg	CRISPR spacer
attaaaaaaaatcaaagcagaggataagctaacg	Protospacer
**********************************

4. spacer 1.2|58913|35|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NC_010381 (Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence) position: , mismatch: 0, identity: 1.0

tatatgggctgataacatttcattaatttgctgca	CRISPR spacer
tatatgggctgataacatttcattaatttgctgca	Protospacer
***********************************

5. spacer 1.2|58913|35|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to MT075580 (Lysinibacillus sphaericus strain SSII-1 plasmid pSSII-1, complete sequence) position: , mismatch: 0, identity: 1.0

tatatgggctgataacatttcattaatttgctgca	CRISPR spacer
tatatgggctgataacatttcattaatttgctgca	Protospacer
***********************************

6. spacer 1.2|58913|35|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014644 (Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

tatatgggctgataacatttcattaatttgctgca	CRISPR spacer
tatatgggctgataacatttcattaatttgctgca	Protospacer
***********************************

7. spacer 1.2|58913|35|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014857 (Lysinibacillus sphaericus III(3)7 plasmid, complete sequence) position: , mismatch: 0, identity: 1.0

tatatgggctgataacatttcattaatttgctgca	CRISPR spacer
tatatgggctgataacatttcattaatttgctgca	Protospacer
***********************************

8. spacer 1.3|58980|33|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NC_010381 (Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence) position: , mismatch: 0, identity: 1.0

attaccatttatatctcttattataaatcttgc	CRISPR spacer
attaccatttatatctcttattataaatcttgc	Protospacer
*********************************

9. spacer 1.3|58980|33|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to MT075580 (Lysinibacillus sphaericus strain SSII-1 plasmid pSSII-1, complete sequence) position: , mismatch: 0, identity: 1.0

attaccatttatatctcttattataaatcttgc	CRISPR spacer
attaccatttatatctcttattataaatcttgc	Protospacer
*********************************

10. spacer 1.3|58980|33|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014644 (Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

attaccatttatatctcttattataaatcttgc	CRISPR spacer
attaccatttatatctcttattataaatcttgc	Protospacer
*********************************

11. spacer 1.3|58980|33|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014857 (Lysinibacillus sphaericus III(3)7 plasmid, complete sequence) position: , mismatch: 0, identity: 1.0

attaccatttatatctcttattataaatcttgc	CRISPR spacer
attaccatttatatctcttattataaatcttgc	Protospacer
*********************************

12. spacer 1.4|59045|34|NZ_CP014857|CRT matches to NZ_CP014857 (Lysinibacillus sphaericus III(3)7 plasmid, complete sequence) position: , mismatch: 0, identity: 1.0

tggtacatgcttatagggtgtctagttagctttc	CRISPR spacer
tggtacatgcttatagggtgtctagttagctttc	Protospacer
**********************************

13. spacer 1.4|59045|34|NZ_CP014857|CRT matches to NC_010381 (Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence) position: , mismatch: 0, identity: 1.0

tggtacatgcttatagggtgtctagttagctttc	CRISPR spacer
tggtacatgcttatagggtgtctagttagctttc	Protospacer
**********************************

14. spacer 1.4|59045|34|NZ_CP014857|CRT matches to NZ_CP014644 (Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

tggtacatgcttatagggtgtctagttagctttc	CRISPR spacer
tggtacatgcttatagggtgtctagttagctttc	Protospacer
**********************************

15. spacer 2.1|59534|48|NZ_CP014857|PILER-CR matches to NZ_CP014857 (Lysinibacillus sphaericus III(3)7 plasmid, complete sequence) position: , mismatch: 0, identity: 1.0

tcagattactaggagatttaagaataaagtattgtcgctctgtgctca	CRISPR spacer
tcagattactaggagatttaagaataaagtattgtcgctctgtgctca	Protospacer
************************************************

16. spacer 2.1|59534|48|NZ_CP014857|PILER-CR matches to NC_010381 (Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence) position: , mismatch: 0, identity: 1.0

tcagattactaggagatttaagaataaagtattgtcgctctgtgctca	CRISPR spacer
tcagattactaggagatttaagaataaagtattgtcgctctgtgctca	Protospacer
************************************************

17. spacer 2.1|59534|48|NZ_CP014857|PILER-CR matches to MT075580 (Lysinibacillus sphaericus strain SSII-1 plasmid pSSII-1, complete sequence) position: , mismatch: 0, identity: 1.0

tcagattactaggagatttaagaataaagtattgtcgctctgtgctca	CRISPR spacer
tcagattactaggagatttaagaataaagtattgtcgctctgtgctca	Protospacer
************************************************

18. spacer 2.1|59534|48|NZ_CP014857|PILER-CR matches to NZ_CP014644 (Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

tcagattactaggagatttaagaataaagtattgtcgctctgtgctca	CRISPR spacer
tcagattactaggagatttaagaataaagtattgtcgctctgtgctca	Protospacer
************************************************

19. spacer 2.2|59600|48|NZ_CP014857|PILER-CR matches to NZ_CP014857 (Lysinibacillus sphaericus III(3)7 plasmid, complete sequence) position: , mismatch: 0, identity: 1.0

atcgatgggaaacgtgctggcctttttagtttaagtcgctctctattt	CRISPR spacer
atcgatgggaaacgtgctggcctttttagtttaagtcgctctctattt	Protospacer
************************************************

20. spacer 2.2|59600|48|NZ_CP014857|PILER-CR matches to NC_010381 (Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence) position: , mismatch: 0, identity: 1.0

atcgatgggaaacgtgctggcctttttagtttaagtcgctctctattt	CRISPR spacer
atcgatgggaaacgtgctggcctttttagtttaagtcgctctctattt	Protospacer
************************************************

21. spacer 2.2|59600|48|NZ_CP014857|PILER-CR matches to MT075580 (Lysinibacillus sphaericus strain SSII-1 plasmid pSSII-1, complete sequence) position: , mismatch: 0, identity: 1.0

atcgatgggaaacgtgctggcctttttagtttaagtcgctctctattt	CRISPR spacer
atcgatgggaaacgtgctggcctttttagtttaagtcgctctctattt	Protospacer
************************************************

22. spacer 2.2|59600|48|NZ_CP014857|PILER-CR matches to NZ_CP014644 (Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

atcgatgggaaacgtgctggcctttttagtttaagtcgctctctattt	CRISPR spacer
atcgatgggaaacgtgctggcctttttagtttaagtcgctctctattt	Protospacer
************************************************

23. spacer 1.1|58847|34|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NC_019325 (Vibrio anguillarum plasmid pJV, complete sequence) position: , mismatch: 3, identity: 0.912

attaaaaaaaatcaaagcagaggataagctaacg	CRISPR spacer
aatgaaaaaaatcaaagcagaggataagctaagg	Protospacer
* *.**************************** *

24. spacer 1.3|58980|33|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033246 (Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence) position: , mismatch: 7, identity: 0.788

attaccatttatatctcttattataa-atcttgc	CRISPR spacer
atcaccatctatatctcttattatagcattcta-	Protospacer
**.*****.****************. **..*.

25. spacer 1.3|58980|33|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033248 (Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence) position: , mismatch: 7, identity: 0.788

attaccatttatatctcttattataa-atcttgc	CRISPR spacer
atcaccatctatatctcttattatagcattcta-	Protospacer
**.*****.****************. **..*.

26. spacer 1.1|58847|34|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NC_012219 (Clostridium botulinum plasmid pC2C203U28 DNA, complete sequence, serotype: type C, strain: (C)-203U28) position: , mismatch: 8, identity: 0.765

attaaaaaaaatcaaagcagaggata-agctaacg	CRISPR spacer
attgaaaaaaatcaaagtagaggatgcagttggt-	Protospacer
***.*************.*******. **.*...

27. spacer 1.1|58847|34|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029459 (Clostridium novyi strain 150557 plasmid pCN1, complete sequence) position: , mismatch: 8, identity: 0.765

attaaaaaaaatcaaagcagaggata-agctaacg	CRISPR spacer
attgaaaaaaatcaaagtagaggatgcagttggt-	Protospacer
***.*************.*******. **.*...

28. spacer 1.1|58847|34|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029459 (Clostridium novyi strain 150557 plasmid pCN1, complete sequence) position: , mismatch: 8, identity: 0.765

attaaaaaaaatcaaagcagaggata-agctaacg	CRISPR spacer
attgaaaaaaatcaaagtagaggatgcagttggt-	Protospacer
***.*************.*******. **.*...

29. spacer 1.3|58980|33|NZ_CP014857|PILER-CR,CRISPRCasFinder,CRT matches to MN693262 (Marine virus AFVG_25M29, complete genome) position: , mismatch: 8, identity: 0.758

attaccatttatatctcttattataaatcttgc	CRISPR spacer
tttaccatttttatttcttattatagcacctgt	Protospacer
 ********* ***.**********.  *.**.

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP014856

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP014856_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014856_1

2449379-2449599

Orphan

Consensus_repeat	Method
TTTTAATTAAACTTTATTTTAAA	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP014856_1

>merge|NZ_CP014856|1|2449379-2449599|CRISPRCasFinder
TTTTAATCAAACTTTTTTATAAAAAATAACTCCTTCACAAAATTAAATCCATCCATTGTGATTAATCTTTTTTCAAAATGGATGGGTTTCTTCTATTGTAAAATCAGCATTTGTAGCACGGTTTTAATTAAACTTTATTTTAAACCAGCACAAAATGGATTCTTCTTATTTACCGTAAAATACGGGTTTGTAAGGTGTTTTTAATTAAACTTTATTTCAAA

>NZ_CP014856|1|1|2449379-2449599|CRISPRCasFinder
TTTTAATCAAACTTTTTTATAAA	AAATAACTCCTTCACAAAATTAAATCCATCCA
TTGTGATTAATCTTTTTTCAAAA	TGGATGGGTTTCTTCTATTGTAAAATCAGCATTTGTAGCACGG
TTTTAATTAAACTTTATTTTAAA	CCAGCACAAAATGGATTCTTCTTATTTACCGTAAAATACGGGTTTGTAAGGTGT
TTTTAATTAAACTTTATTTCAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014856.1\|WP_012293832.1\|2445851_2446862_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|236060
NZ_CP014856.1\|WP_012293824.1\|2439668_2440403_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|379263
NZ_CP014856.1\|WP_012293828.1\|2443325_2443724_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP014856.1\|WP_036161262.1\|2451239_2451470_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014856.1\|WP_036162670.1\|2443723_2444920_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NZ_CP014856.1\|WP_031419520.1\|2447001_2447883_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP014856.1\|WP_012293845.1\|2457794_2459612_-\|oligoendopeptidase-F	unknown	unknown	gnl\|CDD\|341072
NZ_CP014856.1\|WP_012293839.1\|2453214_2453961_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP014856.1\|WP_012293827.1\|2442607_2443162_-\|DJ-1/PfpI-family-protein	unknown	unknown	gnl\|CDD\|153243
NZ_CP014856.1\|WP_051563215.1\|2450319_2451168_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173803
NZ_CP014856.1\|WP_031419511.1\|2442251_2442572_+\|DUF3889-domain-containing-protein	unknown	unknown	gnl\|CDD\|372435
NZ_CP014856.1\|WP_031419527.1\|2455743_2456136_-\|ribonuclease-HI-family-protein	unknown	unknown	gnl\|CDD\|260011
NZ_CP014856.1\|WP_012293844.1\|2456583_2457567_-\|SEC-C-domain-containing-protein	unknown	unknown	gnl\|CDD\|376935
NZ_CP014856.1\|WP_012293843.1\|2456326_2456518_+\|zinc-finger-domain-containing-protein	unknown	unknown	gnl\|CDD\|378493
NZ_CP014856.1\|WP_031419525.1\|2453972_2454629_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP014856.1\|WP_012293825.1\|2440820_2441657_+\|type-II-pantothenate-kinase	unknown	unknown	gnl\|CDD\|237346
NZ_CP014856.1\|WP_031419526.1\|2454694_2455492_-\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270217
NZ_CP014856.1\|WP_036161260.1\|2449745_2450306_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014856.1\|WP_031419509.1\|2441785_2442010_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014856.1\|WP_012293835.1\|2448240_2448630_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP014856.1\|WP_012293832.1\|2445851_2446862_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|236060	PRK07581, PRK07581, hypothetical protein; Validated.	0
NZ_CP014856.1\|WP_012293824.1\|2439668_2440403_+\|SDR-family-oxidoreductase	gnl\|CDD\|379263	pfam13561, adh_short_C2, Enoyl-(Acyl carrier protein) reductase.	2.83016e-83
NZ_CP014856.1\|WP_012293828.1\|2443325_2443724_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.82965e-25
NZ_CP014856.1\|WP_031419526.1\|2454694_2455492_-\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270217	cd00996, PBP2_AatB_like, Polar amino acids-binding domain of ATP-binding cassette transporter-like systems that belong to the type 2 periplasmic binding fold protein superfamily. This subfamily includes periplasmic binding domain of ATP-binding cassette transporter-like systems that serve as initial receptors in the ABC transport of amino acids and their derivatives in eubacteria. After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically-located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The Abp proteins belong to the PBPI superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.16192e-113
NZ_CP014856.1\|WP_036162670.1\|2443723_2444920_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.25827e-81
NZ_CP014856.1\|WP_031419520.1\|2447001_2447883_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	5.64464e-63
NZ_CP014856.1\|WP_012293845.1\|2457794_2459612_-\|oligoendopeptidase-F	gnl\|CDD\|341072	cd09609, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3B oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and is similar to oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity. The PepF gene is duplicated in L. lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid.	0
NZ_CP014856.1\|WP_012293839.1\|2453214_2453961_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	2.67607e-134
NZ_CP014856.1\|WP_012293827.1\|2442607_2443162_-\|DJ-1/PfpI-family-protein	gnl\|CDD\|153243	cd03169, GATase1_PfpI_1, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	8.47678e-84
NZ_CP014856.1\|WP_051563215.1\|2450319_2451168_-\|S8-family-serine-peptidase	gnl\|CDD\|173803	cd07477, Peptidases_S8_Subtilisin_subset, Peptidase S8 family domain in Subtilisin proteins. This group is composed of many different subtilisins: Pro-TK-subtilisin, subtilisin Carlsberg, serine protease Pb92 subtilisin, and BPN subtilisins just to name a few. Pro-TK-subtilisin is a serine protease from the hyperthermophilic archaeon Thermococcus kodakaraensis and consists of a signal peptide, a propeptide, and a mature domain. TK-subtilisin is matured from pro-TK-subtilisin upon autoprocessing and degradation of the propeptide. Unlike other subtilisins though, the folding of the unprocessed form of pro-TK-subtilisin is induced by Ca2+ binding which is almost completed prior to autoprocessing. Ca2+ is required for activity unlike the bacterial subtilisins. The propeptide is not required for folding of the mature domain unlike the bacterial subtilases because of the stability produced from Ca2+ binding. Subtilisin Carlsberg is extremely similar in structure to subtilisin BPN'/Novo thought it has a 30% difference in amino acid sequence. The substrate binding regions are also similar and 2 possible Ca2+ binding sites have been identified recently. Subtilisin Carlsberg possesses the highest commercial importance as a proteolytic additive for detergents. Serine protease Pb92, the serine protease from the alkalophilic Bacillus strain PB92, also contains two calcium ions and the overall folding of the polypeptide chain closely resembles that of the subtilisins. Members of the peptidases S8 and S35 clan include endopeptidases, exopeptidases and also a tripeptidyl-peptidase. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The S53 family contains a catalytic triad Glu/Asp/Ser. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	3.63882e-47
NZ_CP014856.1\|WP_031419511.1\|2442251_2442572_+\|DUF3889-domain-containing-protein	gnl\|CDD\|372435	pfam13028, DUF3889, Protein of unknown function (DUF3889). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two completely conserved residues (A and Y) that may be functionally important.	3.94589e-29
NZ_CP014856.1\|WP_031419527.1\|2455743_2456136_-\|ribonuclease-HI-family-protein	gnl\|CDD\|260011	cd09279, RNase_HI_like, RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD) residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Most archaeal genomes contain only type 2 RNase H (RNase HII); however, a few contain RNase HI as well. Although archaeal RNase HI sequences conserve the DEDD active-site motif, they lack other common features important for catalytic function, such as the basic protrusion region. Archaeal RNase HI homologs are more closely related to retroviral RNase HI than bacterial and eukaryotic type I RNase H in enzymatic properties.	3.77189e-52
NZ_CP014856.1\|WP_012293844.1\|2456583_2457567_-\|SEC-C-domain-containing-protein	gnl\|CDD\|376935	pfam02810, SEC-C, SEC-C motif. The SEC-C motif found in the C-terminus of the SecA protein, in the middle of some SWI2 ATPases and also solo in several proteins. The motif is predicted to chelate zinc with the CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain.	3.6762e-12
NZ_CP014856.1\|WP_012293843.1\|2456326_2456518_+\|zinc-finger-domain-containing-protein	gnl\|CDD\|378493	pfam10782, zf-C2HCIx2C, Zinc-finger. This bacterial family of proteins is a zinc-finger domain of the C2HC type with an additional cysteine.	2.10345e-22
NZ_CP014856.1\|WP_031419525.1\|2453972_2454629_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	3.91768e-70
NZ_CP014856.1\|WP_012293825.1\|2440820_2441657_+\|type-II-pantothenate-kinase	gnl\|CDD\|237346	PRK13317, PRK13317, pantothenate kinase; Provisional.	1.70999e-130

>NZ_CP014856.1|WP_012293835.1|2448240_2448630_+|hypothetical-protein
MLRKIIIISFALIFLCVGCSNDTKKIILEMADENGDFKESLEILDKDQVSIINKILTKVKWKEKSKESFGLLKFRMSFDFIDPDKELKSSYYLIYVNSKEQVTLVENDMKYTKLSKEESKELLEILANK
>NZ_CP014856.1|WP_031419520.1|2447001_2447883_+|LysR-family-transcriptional-regulator
MELRQLKTFYTLASTLNFSRAAEVQNYVPSTVTMQMKALEEELGVKLVDRLGKKVILTDAGRRFLDYVVRILSELEEAEHAVKQSGEMTGTLVISADETLCTYRLPAILRLFRLRYPGIRLIFKPLSHANLKQSLREGDADIIFMLDEDKHEIGFCGEKMQDESFYILVAPDHPLASRTELDIEDFNGETFLLTEKGCSYRTFFERSLSQKGMGGITELEFNSAEAIKQCAKIGMGIAILPEMAVTAELSRGELVSLPWDMSATSFATQMFWHEEKWISPAIQAFLNLARDFA
>NZ_CP014856.1|WP_012293832.1|2445851_2446862_-|alpha/beta-fold-hydrolase
MKDYKLYELGDIQLQSGDILPNAVLAYQTYGTLNAEKNNAIVYPTWFAGLHTDNEWLIGTGKALDPEKYFIIIPNMLGNGLSSSPSNTPAPYHQANFPLISIYDNVRLQHQLVTQKFGISKIALVVGWSLGAVQTFQWGASYPEMVERIAPFGGTAMTRPHAKVVFEGMIAALQADSNWKNGFYTEQPKEGLAAMGRVYAAWGFSQAYYLEQLYQQEGYETLEEYLVDYWDQVFLSFDANDLISMLRTGITGNISANSTYDGDFELALSKITARALVMPGSTDLFFPPEDNNYDALHMPNARFLPIESKWGHCAGIGQHEPDSEFIDKNLKMLLLE
>NZ_CP014856.1|WP_036162670.1|2443723_2444920_+|MFS-transporter
MNLQQGKNTQIWTKRFISLFLTNISVFFVFYGLVTTLPLYAIGELHQTDKEAGLLLSGFLLSAIIVRPFSGKLLDVFGKKKLLVLSIAGYFACTVLYLFIHPFGLLLGLRFIQGIFFSIITTAAGSLAADIVPAKRKGAGLGYFTMSTNLAVVIGPFIGLLLIQYSTFNVLFIVMSFCILAGGILALTVHTDDLPQPAHKGKLTFTFHDLFERKALPVAAIASLVAFSYASVLSFLSVYAQQKGLMAVASLFYAVFAAAMLITRPYTGKLYDTKGPQFVIIPGIISFAIGLIMLAFVEGPMLFLSAAIFVGFGYGAVTTSLQALAVQSTAIQRSGYATATYFTMFDLGIALGSYILGMVAVQAGYASVYLSGAGLLGVVFIIYLLRLAKMKPKKVVNI
>NZ_CP014856.1|WP_012293828.1|2443325_2443724_+|MarR-family-transcriptional-regulator
MNPIFHALFQKSRYLTNCLNEVLKQHQLYSSQWTILYCLHKNGPMTLTQIWKYLNVEAPSITRAITRLETLGWVERLDGEDKREKIVTLTAQANDRLPAITETILAFEEEMVGSLTAEEQQQFMILLEKMKG
>NZ_CP014856.1|WP_012293827.1|2442607_2443162_-|DJ-1/PfpI-family-protein
MGKRVLILAGDAVEALEIFYPYYRCLEAGFDVTIAAPSAKKLQTVLHDFVEGVDTYIERPAYGLEAHASFADIDPSQFDGLMIPGGRAPEYIRLNEYVPTIVSHFFETNKPIAAVCHAAQIFATIPEVLKGRELTAYIACKPEVQVAGATYIDANLHTDGNLVSGHAWPDLPGLMHEFIKKLEG
>NZ_CP014856.1|WP_031419511.1|2442251_2442572_+|DUF3889-domain-containing-protein
MKNVYVMLGLLFAVPLHIPEIVLAQQETPAYAKWGKLAVEEVKGKYPHAKIVDYLHEGKEVHGASTIEKFKLWLKQPDKEFGVHVRISYLTSTQEVEKIELQESQS
>NZ_CP014856.1|WP_031419509.1|2441785_2442010_+|hypothetical-protein
MGNRNNKNSKKTMNARTHNPFGTYKSKDLDRSNSNNNNPNDNLNEEFAAEFDAKAKNKNNKTNHDKNQQSNKKN
>NZ_CP014856.1|WP_012293825.1|2440820_2441657_+|type-II-pantothenate-kinase
MPKAIGIDAGGTLTKVAYLDEDNELILTTFPSNDLLSVKNWIIDHPDIEDIGVTGGRTEQLLDVIKTMKSIHYIVEFEATLKGVRFLLNKEGYLFERSMITNIGTGTSIHYMEDNTHIRVGGTGVGGGTLIGLSALTTGITDYNEIREMAANGHREGIDLLVKDIYQGMDTPIDGHLTASNFGKVGITQSMKHPAEDIIATVQGLVGEVITTLSIQYAEEKNTQHIVYIGSTLSNNEHLARVIANYTRTKKHTPVFINDHGFSGAVGALLNITEYTIV
>NZ_CP014856.1|WP_012293824.1|2439668_2440403_+|SDR-family-oxidoreductase
MGRLNNKITMITGGASGMGAAMAKLFAQEGATVIAADINEENLAKISELENVEGMKLDVSSDENWAEVTKAIVEKYGRIDILINNAGISSEKGPDQITQADWSIMHNINAFGPFLGIKHASKYMKEAGKGSIVNTSSYTAIIGAGFNAYTASKGSLRAIARAAASELGAFNVRVNTVFPGVIETPMTAKLSEAKEAMDMLVKTTPMGRLGQPEEVANAILFLASDEASYITGAELVIDGGYSAR
>NZ_CP014856.1|WP_036161260.1|2449745_2450306_-|hypothetical-protein
MIKKMFKLVPLLILTLLFSAIASPISKANEVAAKDDAINNSTYYSVKTHEIVLFEEEALSLNPYLENQELNYVKNYLKNLSDEEIDEILIQNGYNLDDIKIDTELGHANIVWFVPIVVGAIIVAGGIIFSALYFSHKEKMTLIDKCYANGGYPEIDSKDKAGAKGTTDGGAATKAGGYKFECKKKK
>NZ_CP014856.1|WP_051563215.1|2450319_2451168_-|S8-family-serine-peptidase
MKSRLILMCFISLFFLNACTNNENKDSWNLKIQNVGNYSKEDGDKKIKIAILDSGINKRHFAKNLITKSYNVITNENKTNDEFDHGTKIASIIIDEKIGINTNVELFDIQVINNKGQTTINNVCDGISKAIEYEADVINMSLGFNTNNKQLKECIDKAHKKNIILVASSGDTMSDISDYPAEYKNVISVAAIDKNKELFGFSSTGKIDFFAPGVDVIAKNNKGNYIRTEGSSIASANFTGVLSIYLNKNIDKKEIYLQDNVEFFNFNGRVINILIFNKNTNK
>NZ_CP014856.1|WP_036161262.1|2451239_2451470_+|hypothetical-protein
MKNVNGDYNYIQIAIIIVFTLLLVFAILIAVKSYFNNKEIGLLSSGCLKNDGEYELVITNKLTQSYEFSCNEKEEQ
>NZ_CP014856.1|WP_012293839.1|2453214_2453961_-|amino-acid-ABC-transporter-ATP-binding-protein
MALMAVTNLKKSFNQVEVLKQISFSVEKNDVIAVIGPSGSGKSTMLRSLIHLEEIDGGSILVDGDYLVQDGVYAKPQEIKNLTAKMGMVFQHFNLFPHLTVQQNLEMAPRLLKQESAEAISSRCLDLLKKIGLSEKANAYPANLSGGQKQRVAIARALMMNPQILLFDEPTSALDPELTGEVLKVMKSLAEDQMTMIVVTHEMGFAREVANKVVFMDDGQIIESDHPDNFFTNPQNDRTKAFLQKNLK
>NZ_CP014856.1|WP_031419525.1|2453972_2454629_-|amino-acid-ABC-transporter-permease
MTDYWQTMIWPMLEGAKMTVILFFIAILISIPFGFLLTLAVKSRIKPLSWLAHTYIYIMRGTPLLLQLLLICFGLPMLPVIGEYLVLDRFVAACLGFILNYAAYFAEIFRGGLLAIDKGQYEAAQVLGLSKWQTTTRVILPQMFRVALPALSNESVTLIKDTALLYAVAVPELLHFAQTAVNRDFTIVPFFIAGAIYLIMTLILTVFFKWLEKRFKFE
>NZ_CP014856.1|WP_031419526.1|2454694_2455492_-|amino-acid-ABC-transporter-substrate-binding-protein
MKRIITLVMMLTAVIVLAACGTSKEKSTEKDPSSADQEKIIIGIDDKFAPMGFRDDKNEIVGFDIDLARAAAEHMGVEAEFQPIDWKTKEAELLSGRIDLIWNGYTITDERKEKVLFTKPYLENSQVVMTKADSKIVKLTDLAGTEVGIQSLSSAADALNGNPIHKEIKTITEFSDNVLALSDLKTGRVDAVVIDAVVAEYYMTQEPDTFKLLEESLAPEQYGIGVKPGNEALLEKLQAALDKMNEDGTAADISTKWFGEDKVLK
>NZ_CP014856.1|WP_031419527.1|2455743_2456136_-|ribonuclease-HI-family-protein
MLEVYIDAASAGNPGPSGIGIFIKGEGQHIQISEYIGETNNHIAEFTALVRGLEEAQKLSSTLVSVRSDSKIVVASMEKEYVKNEEFKPFLEKALSLSNTFDLFFIKWVPDSQNKAADALARKAIQNNNH
>NZ_CP014856.1|WP_012293843.1|2456326_2456518_+|zinc-finger-domain-containing-protein
MDKVTVMKDIDELHDTYCADCLVIQQLRKERGKPGAHRFCIEACSIGEKLQFLGEELLKVYSK
>NZ_CP014856.1|WP_012293844.1|2456583_2457567_-|SEC-C-domain-containing-protein
MVKRNDPCPCGSGKKYKKCCEGKQQVTVETVQIEELERVLQTFYLEYPERKDVRAYIEHVGTWQPKLESVLQRELIEAIALDDFFFHQEPSIWKSYLKKTKKKAVRPSTVKVLEDWSHPALFIGTVSVVEENYFKASHLLTNEELYIRRENDKPIPEGMHVFAFILPDGTKKLSHYLAVSTLIFFPEDHLKVFEEFKKNFEASEKKVGAFLKEEHLAFWELLVSNGYKGEEFTNFESTVLSQVKEFLEQNDRETAPMLELLEDYLIEGQPTARKEAAIVAGAIRYGQEKELFESLSMTVKEIAATFDISASSLTKYYQDLNSYVETK
>NZ_CP014856.1|WP_012293845.1|2457794_2459612_-|oligoendopeptidase-F
MEVLPLRKDIAVEETWDLTDLLKNDADFEPTLAQLVEEAISFEQTYKGTITDAQKVIDVLTAFENLQKSIVPIGTYASLNLQADRTDDVAQMRAAKFSTAIGKISSALSFVRSELLALDEAVLQEAATLSPLYKHYLEELLKRKPHQLHPEVEKALAAFSSTFDAPYETYNTTKLVDMNFGEFEANGEKHPLSFVLYENDWEFEANTEVRRAAFKAFSSKLSDYQHTTAQVYNTHIQQEKTMADLRGFDSIFDYLLFDQDVDRSLYNRQIDLISKELAPHMRRYAKLIQKANGIEHMTFADLKIALDAAYDPKLSMDEAKEYVDKALAIMGEDYNHLIDRAFKERWIDYAPNKGKSTGAFCSSPYGSHPYILMSWNERMNEVFTLIHELGHAGHFANTHAHQSYFNSRPSLYFIEAPSTMNEMLLANYLLTHNEDVRFKRWVISNIVSKTYYHNFVTHLLEAAYQRKVYELVDAGESVNANILNQLKRSVLEDFWGDAVDITEGVELTWMRQPHYYMGLYPYTYSAGLTISTQVSQRILKEGDAAVEEWLAVLQAGGTKSPVELAQMAGVDITTDQPLRDTIAYIGHLVDELERLTLEIEAVQQS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

142628 : 151040

Synechococcus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012292017.1\|142628_143198_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.3e-23	37.3
WP_012292016.1\|143197_144253_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	8.6e-61	43.7
WP_012292015.1\|144346_145771_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.4e-52	34.0
WP_012292014.1\|145746_147981_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.4e-156	40.4
WP_012292013.1\|147967_148651_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_012292012.1\|148653_148902_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_012292011.1\|148904_149615_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SS43	Cyanophage	3.4e-45	41.0
WP_012292010.1\|149744_151040_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	4.7e-16	31.5

DBSCAN-SWA_2

172922 : 180390

Bacillus_virus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012291991.1\|172922_173747_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	3.8e-72	54.2
WP_036160402.1\|173765_175226_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	5.0e-115	46.7
WP_012291989.1\|175538_175880_+	P-II family nitrogen regulator	NA	NA	NA	NA
WP_012291988.1\|175893_177195_+	ammonium transporter	H8ZJB2	Ostreococcus_tauri_virus	1.8e-68	40.5
WP_012291987.1\|177261_177762_-	methylated-DNA--[protein]-cysteine S-methyltransferase	A0A0G2Y1B6	Acanthamoeba_polyphaga_mimivirus	3.2e-21	46.6
WP_012291986.1\|177861_178593_+	phosphate ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.1e-17	34.6
WP_012291985.1\|178589_179342_+	iron export ABC transporter permease subunit FetB	NA	NA	NA	NA
WP_012291984.1\|179415_180390_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	1.1e-86	51.1

DBSCAN-SWA_3

1313103 : 1374421

Bacillus_phage(54.55%)

transposase,integrase

attL 1317063:1317121|attR 1384337:1384395

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_139015310.1\|1313103_1314455_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.9e-124	81.8
WP_036160752.1\|1315983_1320855_+	DNRLRE domain-containing protein	I1TLF2	Bacillus_phage	3.4e-11	26.6
1317063:1317121	attL	NA	NA	NA	NA
WP_036160758.1\|1323035_1325192_+	hypothetical protein	NA	NA	NA	NA
WP_012292800.1\|1326198_1326399_+	hypothetical protein	NA	NA	NA	NA
WP_036160763.1\|1327161_1327527_+	hypothetical protein	I1TLF2	Bacillus_phage	2.3e-05	45.1
WP_012292803.1\|1327513_1328989_+	DNRLRE domain-containing protein	NA	NA	NA	NA
WP_012292804.1\|1328991_1331979_+	RHS repeat-associated core domain-containing protein	NA	NA	NA	NA
WP_012292805.1\|1331991_1332360_+	hypothetical protein	NA	NA	NA	NA
WP_012292806.1\|1333048_1333303_+	hypothetical protein	NA	NA	NA	NA
WP_080695165.1\|1333387_1333891_+	RHS repeat-associated core domain-containing protein	NA	NA	NA	NA
WP_012292809.1\|1334068_1334683_+	hypothetical protein	NA	NA	NA	NA
WP_139015351.1\|1335247_1335673_+	hypothetical protein	NA	NA	NA	NA
WP_012292811.1\|1335800_1336277_+	hypothetical protein	NA	NA	NA	NA
WP_036160766.1\|1336948_1337242_+	hypothetical protein	NA	NA	NA	NA
WP_139015311.1\|1338735_1339053_+	hypothetical protein	NA	NA	NA	NA
WP_139015312.1\|1339401_1339596_+	hypothetical protein	A0A1P8CWQ3	Bacillus_phage	2.3e-12	67.3
WP_080695166.1\|1339547_1339808_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A1P8CWQ3	Bacillus_phage	2.0e-11	65.4
WP_012292817.1\|1339849_1340257_+	hypothetical protein	NA	NA	NA	NA
WP_139015313.1\|1342535_1343414_-	hypothetical protein	NA	NA	NA	NA
WP_012292822.1\|1343952_1344414_+	hypothetical protein	NA	NA	NA	NA
WP_036160769.1\|1346318_1346894_+	hypothetical protein	NA	NA	NA	NA
WP_036160771.1\|1347480_1350093_-	hypothetical protein	A0A0K2CYN4	Paenibacillus_phage	2.5e-133	35.9
WP_012292826.1\|1350277_1352626_-	EAL domain-containing protein	G3MA91	Bacillus_virus	4.3e-20	34.3
WP_012292827.1\|1353299_1354733_-	HTH domain-containing protein	NA	NA	NA	NA
WP_012292828.1\|1355974_1356847_-	hypothetical protein	NA	NA	NA	NA
WP_012292829.1\|1357171_1357609_+	hypothetical protein	NA	NA	NA	NA
WP_080695167.1\|1357748_1357847_-	hypothetical protein	NA	NA	NA	NA
WP_012292831.1\|1358714_1360448_+	methyl-accepting chemotaxis protein	NA	NA	NA	NA
WP_012292832.1\|1361141_1361885_+	hypothetical protein	NA	NA	NA	NA
WP_036160776.1\|1362513_1362834_-	DUF4183 domain-containing protein	NA	NA	NA	NA
WP_012292834.1\|1362881_1363292_-	DUF4183 domain-containing protein	NA	NA	NA	NA
WP_139015314.1\|1364098_1364509_-	hypothetical protein	NA	NA	NA	NA
WP_036160781.1\|1364930_1366058_-	Ger(x)C family spore germination protein	NA	NA	NA	NA
WP_012292837.1\|1366087_1367488_-	spore germination protein	NA	NA	NA	NA
WP_036160788.1\|1369930_1370824_+\|integrase	tyrosine-type recombinase/integrase	A0A0K2CP59	Brevibacillus_phage	1.4e-19	25.7
WP_012292840.1\|1370829_1371663_+\|integrase	tyrosine-type recombinase/integrase	A0A142F1N9	Bacillus_phage	3.0e-16	26.5
WP_080695238.1\|1372604_1373579_+\|integrase	tyrosine-type recombinase/integrase	W5RV39	Staphylococcus_phage	1.0e-07	25.5
WP_036160791.1\|1373584_1374421_+\|integrase	tyrosine-type recombinase/integrase	A0A0K2CP59	Brevibacillus_phage	2.3e-24	30.3
1384337:1384395	attR	NA	NA	NA	NA

DBSCAN-SWA_4

2065793 : 2082643

Clostridium_phage(56.25%)

tail,holin,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012293468.1\|2065793_2066126_+	hypothetical protein	A0A290FZR5	Caldibacillus_phage	5.2e-12	33.9
WP_012293469.1\|2066922_2067381_+	hypothetical protein	NA	NA	NA	NA
WP_139015320.1\|2067352_2067565_+	hypothetical protein	NA	NA	NA	NA
WP_012293471.1\|2067566_2068889_+	hypothetical protein	X5JAJ1	Clostridium_phage	2.5e-126	51.6
WP_012293472.1\|2068904_2069420_+\|tail	phage tail tube protein	A0A0A8WJ62	Clostridium_phage	4.5e-47	58.4
WP_012293473.1\|2069480_2069915_+	hypothetical protein	X5JAB6	Clostridium_phage	5.7e-27	45.9
WP_008174525.1\|2069944_2070109_+	hypothetical protein	NA	NA	NA	NA
WP_012293474.1\|2070323_2072246_+	hypothetical protein	A0A0A8WJT6	Clostridium_phage	3.7e-17	23.8
WP_036161043.1\|2072238_2072922_+	LysM peptidoglycan-binding domain-containing protein	A0A0A8WFE5	Clostridium_phage	4.9e-41	47.9
WP_139015321.1\|2072914_2073877_+	hydrolase	H7BVH4	unidentified_phage	3.8e-87	50.6
WP_012293477.1\|2073878_2074193_+	DUF2577 domain-containing protein	A0A0A7RTJ2	Clostridium_phage	3.9e-09	30.8
WP_012293478.1\|2074192_2074597_+	DUF2634 domain-containing protein	A0A0A8WFW6	Clostridium_phage	4.7e-31	52.8
WP_012293479.1\|2074596_2075682_+\|plate	baseplate J/gp47 family protein	A0A0A8WJT7	Clostridium_phage	1.4e-85	48.4
WP_012293480.1\|2075674_2076223_+	DUF2313 domain-containing protein	A0A0A8WII4	Clostridium_phage	2.6e-16	32.9
WP_012293481.1\|2076222_2077848_+	hypothetical protein	S6B1J7	Thermus_phage	1.2e-24	50.7
WP_012293482.1\|2077861_2078281_+	hypothetical protein	NA	NA	NA	NA
WP_051563194.1\|2078455_2078761_+	hypothetical protein	A0A0H3UZE6	Geobacillus_virus	1.3e-09	38.6
WP_012293484.1\|2078773_2079040_+\|holin	holin	A0A2H4JAH4	uncultured_Caudovirales_phage	4.0e-15	53.6
WP_012293485.1\|2079036_2079759_+	N-acetylmuramoyl-L-alanine amidase	A0A060AC40	Listeria_phage	2.9e-44	49.1
WP_012293486.1\|2080188_2081601_+	hypothetical protein	NA	NA	NA	NA
WP_012293487.1\|2081815_2082643_+	M23 family metallopeptidase	D6QWN5	uncultured_phage	4.3e-15	38.4

DBSCAN-SWA_5

2983238 : 3033265

Paenibacillus_phage(16.67%)

integrase,transposase,protease,tRNA

attL 2975966:2975982|attR 3034024:3034040

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2975966:2975982	attL	NA	NA	NA	NA
WP_012294431.1\|2983238_2983862_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_036161646.1\|2984180_2984603_+	hypothetical protein	NA	NA	NA	NA
WP_012294433.1\|2984910_2985873_+	YafY family transcriptional regulator	A0A1B0RXM1	Streptococcus_phage	4.7e-13	28.0
WP_012294434.1\|2985949_2986582_+	glutamine amidotransferase	NA	NA	NA	NA
WP_081112813.1\|2986798_2987170_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_012294436.1\|2987173_2987500_+\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	3.0e-28	62.3
WP_080695197.1\|2987441_2987609_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_012294438.1\|2987712_2988369_-	response regulator transcription factor	NA	NA	NA	NA
WP_080695198.1\|2990018_2990459_+	hypothetical protein	NA	NA	NA	NA
WP_012294440.1\|2990957_2991938_+	hypothetical protein	A0A2I7SC07	Paenibacillus_phage	7.6e-19	28.0
WP_012294441.1\|2992098_2992428_+	hypothetical protein	NA	NA	NA	NA
WP_051563241.1\|2992452_2992785_+	DUF4288 domain-containing protein	NA	NA	NA	NA
WP_036161659.1\|2993815_2994253_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012294444.1\|2994249_2995431_+	glucosyltransferase	Q6QXI9	Agrotis_segetum_granulosis_virus	9.5e-08	27.0
WP_031415857.1\|2996337_2997360_+	alpha/beta hydrolase	M1PGN2	Moumouvirus	1.3e-16	26.3
WP_036161662.1\|2997649_2998576_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_012294449.1\|2999190_3000690_+	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	9.9e-10	37.2
WP_139015334.1\|3001733_3002882_+	copper amine oxidase N-terminal domain-containing protein	NA	NA	NA	NA
WP_012294451.1\|3003080_3003221_-	hypothetical protein	NA	NA	NA	NA
WP_012294452.1\|3003811_3005698_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_012294454.1\|3006139_3007813_+\|tRNA	arginine--tRNA ligase	A0A2I2L3K1	Orpheovirus	1.4e-73	32.5
WP_036161666.1\|3007913_3009089_+	MFS transporter	NA	NA	NA	NA
WP_012294457.1\|3009345_3010446_+	hypothetical protein	NA	NA	NA	NA
WP_036161669.1\|3010453_3012226_+	DNA helicase RecQ	A0A0G2Y8K9	Acanthamoeba_polyphaga_mimivirus	3.5e-70	35.4
WP_012294459.1\|3012303_3012825_-	peptide-methionine (S)-S-oxide reductase MsrA	NA	NA	NA	NA
WP_012294460.1\|3013001_3013952_+	LCP family protein	NA	NA	NA	NA
WP_012294461.1\|3014016_3015216_+	AI-2E family transporter	NA	NA	NA	NA
WP_012294462.1\|3015694_3016870_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_012294463.1\|3017181_3017997_+	ATP-binding protein	NA	NA	NA	NA
WP_031415877.1\|3018247_3018568_-	hypothetical protein	NA	NA	NA	NA
WP_012294465.1\|3018826_3019621_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_012294466.1\|3019982_3020858_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_012294467.1\|3020910_3021765_-	transglutaminase family protein	NA	NA	NA	NA
WP_080695199.1\|3021826_3022792_-	alpha-E domain-containing protein	NA	NA	NA	NA
WP_012294469.1\|3022745_3024233_-	circularly permuted type 2 ATP-grasp protein	NA	NA	NA	NA
WP_036161672.1\|3024311_3024725_+	hypothetical protein	NA	NA	NA	NA
WP_012294471.1\|3025064_3026027_+	tyrosine recombinase XerC	A0A160DCT0	Gordonia_phage	8.5e-15	29.6
WP_012294472.1\|3026080_3026578_+	DinB family protein	NA	NA	NA	NA
WP_004230023.1\|3027172_3027322_+	hypothetical protein	NA	NA	NA	NA
WP_012294474.1\|3027525_3027696_+	hypothetical protein	NA	NA	NA	NA
WP_012294475.1\|3028073_3029795_+	phosphodiesterase	G3MA91	Bacillus_virus	2.6e-14	33.9
WP_036161675.1\|3030127_3031564_+\|tRNA	proline--tRNA ligase	A0A2K9L3R9	Tupanvirus	4.9e-99	38.8
WP_012294477.1\|3032095_3033265_-\|transposase	transposase	D2XQ03	Bacillus_virus	1.8e-96	49.7
3034024:3034040	attR	NA	NA	NA	NA

DBSCAN-SWA_6

3243524 : 3249536

Pneumococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012294683.1\|3243524_3244064_-	hypothetical protein	E7DND6	Pneumococcus_phage	1.0e-04	27.0
WP_036161829.1\|3244109_3244838_-	7-carboxy-7-deazaguanine synthase QueE	E7DN68	Pneumococcus_phage	4.7e-50	43.4
WP_012294685.1\|3244830_3245304_-	6-carboxytetrahydropterin synthase QueD	J9PV91	Bacillus_phage	3.3e-60	72.2
WP_012294686.1\|3245306_3245966_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	6.6e-67	56.3
WP_031418567.1\|3246085_3246586_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	4.4e-47	61.1
WP_012294688.1\|3247181_3249536_+	peptidase	E3T4I7	Cafeteria_roenbergensis_virus	6.4e-72	30.0

DBSCAN-SWA_7

3815849 : 3889227

Vibrio_phage(18.92%)

transposase,head,tRNA,coat,tail,holin,plate,capsid,portal,integrase,terminase,protease

attL 3854704:3854726|attR 3879726:3879748

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080695219.1\|3815849_3816092_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A0N9SIX5	Staphylococcus_phage	9.0e-14	62.9
WP_012295236.1\|3816218_3816443_-	hypothetical protein	NA	NA	NA	NA
WP_012295237.1\|3816458_3817580_-	Nif3-like dinuclear metal center hexameric protein	NA	NA	NA	NA
WP_031417022.1\|3817580_3818273_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_012295240.1\|3818437_3818797_-	cytochrome c	NA	NA	NA	NA
WP_036162150.1\|3819110_3819674_-	hypothetical protein	NA	NA	NA	NA
WP_012295242.1\|3819906_3821034_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	2.4e-37	38.1
WP_012295243.1\|3821066_3822899_-	DNA primase	A0A1S5RH72	Helicobacter_phage	6.6e-48	34.8
WP_008178459.1\|3823106_3823919_-	kinase/pyrophosphorylase	NA	NA	NA	NA
WP_008178461.1\|3823936_3824569_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012295244.1\|3825248_3826634_+\|tRNA	glycine--tRNA ligase	A0A2I2L3K8	Orpheovirus	2.2e-48	31.1
WP_031417025.1\|3826684_3828403_-	HD domain-containing protein	NA	NA	NA	NA
WP_036162156.1\|3829151_3830555_+	S-layer homology domain-containing protein	NA	NA	NA	NA
WP_036162158.1\|3830579_3831368_-	DNA repair protein RecO	NA	NA	NA	NA
WP_036162160.1\|3831559_3832477_-	GTPase Era	NA	NA	NA	NA
WP_008179431.1\|3832463_3832877_-	cytidine deaminase	NA	NA	NA	NA
WP_012295251.1\|3832942_3833293_-	diacylglycerol kinase family protein	NA	NA	NA	NA
WP_012295252.1\|3833293_3833767_-	rRNA maturation RNase YbeY	NA	NA	NA	NA
WP_012295253.1\|3833775_3835896_-	HD family phosphohydrolase	NA	NA	NA	NA
WP_031417032.1\|3836119_3837076_-	PhoH family protein	L7TP00	Rhizobium_phage	3.2e-46	46.9
WP_012295255.1\|3837078_3838191_-	stage IV sporulation protein	NA	NA	NA	NA
WP_012295256.1\|3838192_3838441_-	hypothetical protein	NA	NA	NA	NA
WP_012295257.1\|3838496_3838976_-	hypothetical protein	NA	NA	NA	NA
WP_008179446.1\|3839001_3840006_-	flotillin-like protein FloA	NA	NA	NA	NA
WP_031417037.1\|3840009_3841338_-	membrane protein	NA	NA	NA	NA
WP_004227078.1\|3841639_3841813_-	30S ribosomal protein S21	NA	NA	NA	NA
WP_036162163.1\|3842322_3843660_+	ATP synthase subunit J	NA	NA	NA	NA
WP_012295261.1\|3843686_3844343_+	TrkA family potassium uptake protein	NA	NA	NA	NA
WP_031417041.1\|3844390_3844960_-	hypothetical protein	NA	NA	NA	NA
WP_012295262.1\|3844984_3845248_-\|coat	spore coat protein CotJB	NA	NA	NA	NA
WP_036162165.1\|3845244_3845469_-\|coat	spore coat associated protein CotJA	NA	NA	NA	NA
WP_012295263.1\|3845595_3846267_-	deoxyribose-phosphate aldolase	NA	NA	NA	NA
WP_012295264.1\|3846791_3847331_-	hypothetical protein	A0A2H4JA12	uncultured_Caudovirales_phage	2.0e-21	67.9
WP_051563278.1\|3847331_3847931_-	hypothetical protein	A0A1S5QTS6	Bacillus_phage	2.0e-46	48.7
WP_036162167.1\|3847872_3849168_-	cell division protein FtsK	A0A2H4J9G1	uncultured_Caudovirales_phage	4.7e-133	57.5
WP_036162170.1\|3849550_3850444_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012295268.1\|3850617_3850821_+	helix-turn-helix transcriptional regulator	A0A0A0RVA6	Bacillus_phage	8.6e-10	45.5
WP_012295269.1\|3850929_3851400_-	hypothetical protein	NA	NA	NA	NA
WP_036162175.1\|3851505_3851844_-	hypothetical protein	NA	NA	NA	NA
WP_036162852.1\|3851837_3852062_-	transcriptional regulator	NA	NA	NA	NA
WP_080695220.1\|3852204_3852900_-	N-acetylmuramoyl-L-alanine amidase	A0A060AC40	Listeria_phage	1.1e-43	50.3
WP_012295273.1\|3852896_3853286_-\|holin	holin	Q8SBN5	Clostridium_phage	2.9e-22	52.1
WP_012295274.1\|3853338_3854595_-	DNA (cytosine-5-)-methyltransferase	A0A141E1L1	Streptococcus_phage	2.4e-134	60.5
3854704:3854726	attL	NA	NA	NA	NA
WP_012295275.1\|3854873_3855314_-	hypothetical protein	S5MUI6	Brevibacillus_phage	3.0e-07	29.7
WP_080695221.1\|3855332_3856688_-\|tail	phage tail protein	A0A2H4J194	uncultured_Caudovirales_phage	8.0e-43	53.4
WP_012295277.1\|3856668_3857316_-\|tail	phage tail protein I	A0A059WLJ8	Vibrio_phage	5.0e-19	31.1
WP_012295278.1\|3857308_3858439_-\|plate	baseplate J/gp47 family protein	A0A067ZJB4	Vibrio_phage	2.4e-69	38.8
WP_036162860.1\|3858428_3858713_-	hypothetical protein	NA	NA	NA	NA
WP_051563280.1\|3858731_3859406_-	SH3 domain-containing protein	A0A067ZI88	Vibrio_phage	3.6e-20	40.9
WP_012295281.1\|3859416_3859608_-	hypothetical protein	NA	NA	NA	NA
WP_012295282.1\|3859607_3860624_-	bacteriophage regulatory protein	A0A0C5AJ59	Bacteriophage	4.2e-44	33.3
WP_036162178.1\|3860620_3860836_-	hypothetical protein	A0A067ZJB1	Vibrio_phage	6.1e-06	37.5
WP_051563282.1\|3860828_3863780_-\|tail	phage tail tape measure protein	A0A0N9SJR9	Paenibacillus_phage	1.7e-98	62.4
WP_012295286.1\|3863928_3864327_-\|tail	phage tail assembly protein	NA	NA	NA	NA
WP_012295287.1\|3864354_3864876_-\|tail	phage major tail tube protein	A0A0E3Y6F4	Fusobacterium_phage	3.8e-25	33.5
WP_036162181.1\|3864893_3866324_-	hypothetical protein	A0A0C5AEE8	Bacteriophage	2.0e-100	41.5
WP_012295288.1\|3866325_3866631_-	hypothetical protein	NA	NA	NA	NA
WP_012295289.1\|3866620_3867112_-	hypothetical protein	NA	NA	NA	NA
WP_012295290.1\|3867111_3867663_-	hypothetical protein	NA	NA	NA	NA
WP_080695222.1\|3867675_3868017_-	hypothetical protein	NA	NA	NA	NA
WP_012295292.1\|3868000_3868366_-	hypothetical protein	NA	NA	NA	NA
WP_012295293.1\|3868377_3869403_-\|capsid	major capsid protein	A0A059WRQ2	Vibrio_phage	1.1e-57	38.1
WP_012295294.1\|3869406_3869772_-\|head	head decoration protein	NA	NA	NA	NA
WP_012295295.1\|3869772_3870840_-\|protease	Clp protease ClpP	A0A0A7RWX3	Clostridium_phage	1.8e-45	49.0
WP_012295296.1\|3870826_3872404_-\|portal	phage portal protein	A0A0C5AJ48	Bacteriophage	2.4e-155	58.3
WP_036162184.1\|3872419_3872653_-	hypothetical protein	A0A067ZJ01	Vibrio_phage	1.1e-13	49.4
WP_036162186.1\|3872628_3874464_-\|terminase	phage terminase large subunit family protein	A0A2K9V3X4	Faecalibacterium_phage	3.5e-174	52.6
WP_012295298.1\|3874423_3875002_-	hypothetical protein	A0A0E3Y4U4	Fusobacterium_phage	4.2e-09	28.0
WP_012295299.1\|3875151_3875346_-	hypothetical protein	NA	NA	NA	NA
WP_012295301.1\|3875740_3876322_-\|integrase	tyrosine-type recombinase/integrase	A0A0S2GLG4	Bacillus_phage	5.6e-46	52.1
WP_012295302.1\|3876318_3876786_-	hypothetical protein	A0A1B1P7B2	Bacillus_phage	5.4e-15	36.2
WP_012295303.1\|3876791_3877127_-	hypothetical protein	NA	NA	NA	NA
WP_012295304.1\|3877221_3877380_-	hypothetical protein	NA	NA	NA	NA
WP_012295306.1\|3877762_3878482_-	hypothetical protein	A0A068EMK6	Bacillus_phage	3.9e-20	30.7
WP_012295307.1\|3878556_3878925_-	hypothetical protein	NA	NA	NA	NA
WP_012295308.1\|3878914_3879121_-	hypothetical protein	NA	NA	NA	NA
WP_012295309.1\|3879120_3879978_-	DUF3102 domain-containing protein	A0A2H4J025	uncultured_Caudovirales_phage	3.3e-18	45.6
3879726:3879748	attR	NA	NA	NA	NA
WP_012295310.1\|3879974_3881516_-	hypothetical protein	A0A0E3XCJ0	Enterococcus_phage	6.4e-12	32.8
WP_051563285.1\|3881528_3882002_-	hypothetical protein	NA	NA	NA	NA
WP_012295313.1\|3881976_3882909_-	hypothetical protein	Q0SPI6	Clostridium_phage	1.0e-33	37.9
WP_012295314.1\|3883196_3883547_-	hypothetical protein	NA	NA	NA	NA
WP_012295315.1\|3883540_3883714_-	hypothetical protein	NA	NA	NA	NA
WP_155726286.1\|3883968_3884124_-	hypothetical protein	NA	NA	NA	NA
WP_051563287.1\|3884310_3884676_+	helix-turn-helix transcriptional regulator	A0A0A8WJK5	Clostridium_phage	1.2e-17	43.4
WP_036162189.1\|3884721_3885084_+	helix-turn-helix transcriptional regulator	A0A0A8WJK5	Clostridium_phage	8.2e-11	33.0
WP_036162191.1\|3885091_3885271_-	hypothetical protein	NA	NA	NA	NA
WP_139015344.1\|3885760_3887674_+	recombinase family protein	A0A0A7RUB1	Clostridium_phage	1.0e-144	49.7
WP_036162193.1\|3887877_3889227_+\|tRNA	tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))- methylthiotransferase MtaB	NA	NA	NA	NA

DBSCAN-SWA_8

4327000 : 4336336

Staphylococcus_phage(66.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_036162332.1\|4327000_4328182_+	NupC/NupG family nucleoside CNT transporter	B2YG43	Musca_hytrovirus	2.5e-08	21.6
WP_012295731.1\|4328326_4330744_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	73.8
WP_031416439.1\|4331105_4332848_-	STAS domain-containing protein	A0A2H4J153	uncultured_Caudovirales_phage	5.8e-46	28.1
WP_012295733.1\|4332905_4333253_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_036162335.1\|4333399_4334578_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	5.8e-106	49.2
WP_031416441.1\|4334804_4335761_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	5.1e-60	75.2
WP_012295735.1\|4335757_4336336_+	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	2.9e-42	49.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP014857

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP014856

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection