CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP014869	Brevibacterium linens strain BS258 chromosome, complete genome	3 crisprs	csa3,WYL,cas3,DEDDh,cas4,DinG	0	0	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP014869_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014869_1

2253677-2253771

Orphan

Consensus_repeat	Method
CTGTAGTTCGGCTGCGAACCGTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP014869_1

>merge|NZ_CP014869|1|2253677-2253771|CRISPRCasFinder
CTGTAGTTCGGCTGCGAACCGTACTGGGGAGCCTGCTGCCCGTACTGCTGCGAACCGTCGTTGCCGCCCTGGCCGTAGTTCGGCTGCGAACCGTA

>NZ_CP014869|1|1|2253677-2253771|CRISPRCasFinder
CTGTAGTTCGGCTGCGAACCGTA	CTGGGGAGCCTGCTGCCCGTACTGCTGCGAACCGTCGTTGCCGCCCTGG
CCGTAGTTCGGCTGCGAACCGTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014869.1\|WP_062861755.1\|2258768_2259257_-\|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl\|CDD\|234575
NZ_CP014869.1\|WP_039207386.1\|2245734_2246331_-\|crossover-junction-endodeoxyribonuclease-RuvC	unknown	unknown	gnl\|CDD\|234587
NZ_CP014869.1\|WP_062861745.1\|2241148_2243263_-\|protein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
NZ_CP014869.1\|WP_062861751.1\|2254912_2255275_+\|TIGR02611-family-protein	unknown	unknown	gnl\|CDD\|131660
NZ_CP014869.1\|WP_082819361.1\|2259253_2260288_-\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|376820
NZ_CP014869.1\|WP_062861753.1\|2256512_2257451_-\|GTPase-Era	unknown	unknown	gnl\|CDD\|234624
NZ_CP014869.1\|WP_062861752.1\|2255405_2256413_-\|cell-division-protein-ZapE	unknown	unknown	gnl\|CDD\|224402
NZ_CP014869.1\|WP_062861757.1\|2262388_2263429_-\|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
NZ_CP014869.1\|WP_062861749.1\|2249845_2250451_-\|HIT-domain-containing-protein	unknown	unknown	gnl\|CDD\|238606
NZ_CP014869.1\|WP_062861756.1\|2260388_2261150_-\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl\|CDD\|367950
NZ_CP014869.1\|WP_062862852.1\|2243334_2243889_-\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|376903
NZ_CP014869.1\|WP_039207381.1\|2250447_2252454_-\|threonine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237050
NZ_CP014869.1\|WP_062861747.1\|2247196_2247676_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240041
NZ_CP014869.1\|WP_062862853.1\|2243979_2245002_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl\|CDD\|234619
NZ_CP014869.1\|WP_062861746.1\|2245073_2245670_-\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NZ_CP014869.1\|WP_039207369.1\|2261146_2262262_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|237654
NZ_CP014869.1\|WP_156483875.1\|2257452_2258766_-\|DUF21-domain-containing-protein	unknown	unknown	gnl\|CDD\|224173
NZ_CP014869.1\|WP_039207384.1\|2246330_2247083_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|234640
NZ_CP014869.1\|WP_062861748.1\|2247806_2249849_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP014869.1\|WP_082819362.1\|2263609_2264473_+\|DUF3097-domain-containing-protein	unknown	unknown	gnl\|CDD\|378628

Protein	Function_ID	Function_description	E-value
NZ_CP014869.1\|WP_062861755.1\|2258768_2259257_-\|rRNA-maturation-RNase-YbeY	gnl\|CDD\|234575	PRK00016, PRK00016, metal-binding heat shock protein; Provisional.	2.19397e-54
NZ_CP014869.1\|WP_039207386.1\|2245734_2246331_-\|crossover-junction-endodeoxyribonuclease-RuvC	gnl\|CDD\|234587	PRK00039, ruvC, Holliday junction resolvase; Reviewed.	5.15234e-75
NZ_CP014869.1\|WP_062861745.1\|2241148_2243263_-\|protein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	3.72325e-114
NZ_CP014869.1\|WP_062861751.1\|2254912_2255275_+\|TIGR02611-family-protein	gnl\|CDD\|131660	TIGR02611, Putative_membrane_protein, TIGR02611 family protein. Members of this family are Actinobacterial putative proteins of about 150 amino acids in length with three apparent transmembrane helix and an unusual motif with consensus sequence PGPGW. [Hypothetical proteins, Conserved].	7.84417e-15
NZ_CP014869.1\|WP_082819361.1\|2259253_2260288_-\|PhoH-family-protein	gnl\|CDD\|376820	pfam02562, PhoH, PhoH-like protein. PhoH is a cytoplasmic protein and predicted ATPase that is induced by phosphate starvation.	5.07986e-135
NZ_CP014869.1\|WP_062861753.1\|2256512_2257451_-\|GTPase-Era	gnl\|CDD\|234624	PRK00089, era, GTPase Era; Reviewed.	1.09568e-162
NZ_CP014869.1\|WP_062861752.1\|2255405_2256413_-\|cell-division-protein-ZapE	gnl\|CDD\|224402	COG1485, COG1485, Predicted ATPase [General function prediction only].	2.53003e-63
NZ_CP014869.1\|WP_062861757.1\|2262388_2263429_-\|heat-inducible-transcriptional-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	1.53142e-132
NZ_CP014869.1\|WP_062861749.1\|2249845_2250451_-\|HIT-domain-containing-protein	gnl\|CDD\|238606	cd01275, FHIT, FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.	7.90676e-66
NZ_CP014869.1\|WP_062861756.1\|2260388_2261150_-\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl\|CDD\|367950	pfam04452, Methyltrans_RNA, RNA methyltransferase. RNA methyltransferases modify nucleotides during ribosomal RNA maturation in a site-specific manner. The Escherichia coli member is specific for U1498 methylation.	4.22767e-56
NZ_CP014869.1\|WP_062862852.1\|2243334_2243889_-\|preprotein-translocase-subunit-YajC	gnl\|CDD\|376903	pfam02699, YajC, Preprotein translocase subunit. See.	6.38828e-18
NZ_CP014869.1\|WP_039207381.1\|2250447_2252454_-\|threonine--tRNA-ligase	gnl\|CDD\|237050	PRK12305, thrS, threonyl-tRNA synthetase; Reviewed.	0
NZ_CP014869.1\|WP_062861747.1\|2247196_2247676_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240041	cd04685, Nudix_Hydrolase_26, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	5.51135e-37
NZ_CP014869.1\|WP_062862853.1\|2243979_2245002_-\|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl\|CDD\|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NZ_CP014869.1\|WP_062861746.1\|2245073_2245670_-\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	2.34543e-67
NZ_CP014869.1\|WP_039207369.1\|2261146_2262262_-\|molecular-chaperone-DnaJ	gnl\|CDD\|237654	PRK14278, PRK14278, chaperone protein DnaJ; Provisional.	1.75189e-166
NZ_CP014869.1\|WP_156483875.1\|2257452_2258766_-\|DUF21-domain-containing-protein	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	7.35631e-88
NZ_CP014869.1\|WP_039207384.1\|2246330_2247083_-\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|234640	PRK00110, PRK00110, YebC/PmpR family DNA-binding transcriptional regulator.	1.51415e-140
NZ_CP014869.1\|WP_062861748.1\|2247806_2249849_-\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	6.08898e-70
NZ_CP014869.1\|WP_082819362.1\|2263609_2264473_+\|DUF3097-domain-containing-protein	gnl\|CDD\|378628	pfam11296, DUF3097, Protein of unknown function (DUF3097). This family of proteins with unknown function appears to be restricted to Actinobacteria.	4.93676e-137

>NZ_CP014869.1|WP_039207381.1|2250447_2252454_-|threonine--tRNA-ligase
MADSIDCAGESIPFKEGLTGTEIFSTDRTVVAMWLNGEPADLSRVLQAGDRIAPITIDSDAGLDILRHSTGHVTAQAVQELFPGTKLGIGPYITDGYYFDFDVAEPFTPEDLKAIQKKAAQIVKSGQTFNRVVVTEDEARARMANEPYKLELIDDKGKGGDEETSVEVGGGELTVYENVDRKGEVVWQDLCRGPHLPNTKLIGNGFAITRSSAAYWRGDQANASLQRVYGTAWASKDDLKAYQDRIAEAERRDHRKLGAEMDLFSFPEELGSGLPVFHPKGGVIKREMEDYVRARHIDEGFEYVGTPHISKETLYYTSGHLPYYGENMFPAMSVDEVRDESGKVVKEGTPYRLKAMNCPMHNLIYRSRGRSYRDLPLRLFEFGTVYRDEASGVIHGLTRVRALTQDDSHSYVAQEDAAAEIRHLLNFVLSLLRDFGLDDFYLELSTRDEEGKKADKFIGSDEQWAEATSVLEEVAQETGLELVPDPGGAAFYGPKISVQARDAIGRTWQMSTVQLDFNQPERFGLEYVAADGSRKQPVMIHSAKFGSIERFLGVLTEHYAGAFPVWLAPVQVTCIPVADEFNDYLAEVADQLRKAGVRVEIDDSDDRFPKKIRNASKSKVPFTLIAGGEDRDAGAVSFRFRSGEQENGVPVAEAVRRILDSIETKAQV
>NZ_CP014869.1|WP_062861749.1|2249845_2250451_-|HIT-domain-containing-protein
MSGGDDDRSAQENPDGRLGEGIPHPEAAAGFPGEPDGFQRLWTPHRMVYIDGQDKPNDDRAEECPFCTAPSKTDEDGLIIARGETVYAVLNLYPYNPGHLLICPYRHVPDYTELTGDETVELAEFTQKAMRVIRAVSGPHGFNLGMNQGPVAGAGIAAHLHQHVVPRWGGDANFLPVIAQTKALPQVHADVQARLSKEWNR
>NZ_CP014869.1|WP_062861748.1|2247806_2249849_-|S9-family-peptidase
MNPEDLGTLAEYSSPVLRGHDTVITIRRPDLESNSYLSQLFSLTEDSSRRLTHSWSDSTPQCGPNWSGYLSGEKKAAPQLFVGDSLETAHQITDNHLGVAEFALDDSRSRALYVARVAEPGRYGLDDSIPAAEEAPRRITTASYLANGLGYTNDRPARAFLVDLAEPGLGTVGLRGASEVPLSTLLTTPDTDVHDPQFSPNGTRVSVISALHPDRGQPDLRSTVWLLGGDDPTPLDLPSMDVGLHRWLDEDTVLLVGNALTRDELDFVGQMPGLFIHDVTTGSTRRLTDPETVALAGVPPRIHGGAVVAAVDADGATRIVRVALDAAEISFDELEFLTDDTTVVNGFDIDDDTLVFTGSTPQSPAVLGRIALRGRAESGTASVMGDTVIVKEHPAPANSVLPQVLRVPGVSGTITGWLAKPHGDGPFPVILNIHGGPFAQYTHSWFDETQVLTSAGYAVVFSNPRGSGGRTRSWGTAVQGDMAQPAMADVLAVLDHALESDPSLDRSRLGIQGGSYGGYLTAMTIAADQRFRAAIVERGYLDPDSFVGTSDIGRFFTEEYTSRSREAIAAQSPLAHAPQVGTPTLVMHSELDLRCPLEQAQQYYAALQRAGVDTEMLIFPGENHELSRAGQPRHRRQRFEAILDWWDRRLSGGNRTQPADERHLSEAADPEAASASDSAS
>NZ_CP014869.1|WP_062861747.1|2247196_2247676_-|NUDIX-domain-containing-protein
MKPRKASRVVLLNERDEVLLIRAQDLLTPSLQWWMTCGGGSELGESAAQTAARELAEETGIECEPHELIGPLATRDEVFEFTEKSLRQVETYFAFRTTEDIELEDAVWTDIEKRSLLEFRWWSREELLATTETIYPRNLLGLIDLATAGSVPEVPLVID
>NZ_CP014869.1|WP_039207384.1|2246330_2247083_-|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MSGHSKWATTKHKKAAIDAKRGKLFAKLIKNIEVAARNGGPDPDGNPTLFDAIQKAKKNSVPADNITRAVKRGGGLDGSGVNYETIMYEGYAAGGVALLIECLTDNRNRAASEVRVAVTRNGGSMADPGSVTYNFNRKGVITVNAEETDEEAILLATMDAGAEEVKEVGEKFEIICEATDLVAVRTALVDAGIDYDSAEASFVPELEVSLDADTAQKVFTLIDALEDSDEVQNVYSNADVSDEVLAELDA
>NZ_CP014869.1|WP_039207386.1|2245734_2246331_-|crossover-junction-endodeoxyribonuclease-RuvC
MRILGVDPGLTRCGLGVIDTLPARKAKMVAVDVLRTPSADSVDLRLGAIAEAFDTWLDTYRPDVVAIERVFARNDVSTIMGTAQASGLTMGLAARRGLPVAMHTPSEVKAAITGSGRADKKQVTSMVTRILGLDAPPKPADAADALAIAICHSWRGALSAQSTPGKNKDLTERKAGGRQGSGLTKAQQQWAEAMRRAR
>NZ_CP014869.1|WP_062861746.1|2245073_2245670_-|Holliday-junction-branch-migration-protein-RuvA
MISFLSGTVHRIAADHLVVLTYGVGRKVHVTPDTLTGTRHGAEIELVTSLVVREDSMTLYGFGTEDENHTFEVLLSISGIGPRLAMAILSVMGPDELAAAITNQDANALTRVPGIGKKGASRIILELENKLPKLTAAAPGPALSFGGGNQQVVDALVGLGWKEAQAEDVVAEVVKETGADAGTSVVLKAALKVLGAKR
>NZ_CP014869.1|WP_062862853.1|2243979_2245002_-|Holliday-junction-branch-migration-DNA-helicase-RuvB
MTGAERERLVSGRAETAERDDEAALRPKGLADFIGQPKVREQLSLVLDAAKARQKAPDHVLLSGPPGLGKTTLAMIVAHEMNSSLRVTSGPAVQHAGDLAAILSSLEEGEVLFIDEIHRMARAAEEMLYVAMEDFRVDVIVGKGPGATAIPLDLPQFTLVGATTRSGLLPAPLRDRFGFTALLDFYSSADLLTVLQRSARMLGIESELAGLQEISTRSRGTPRIANRLLRRVRDWAQVRGNGIIDEEAATNALRVYEVDELGLDRLDRSVLQVLCKRFGGGPVGLGTLAVSVGEEADTVETVSEPYLVREGLISRTPRGRVATTAAWEHLKMQIPANYEF
>NZ_CP014869.1|WP_062862852.1|2243334_2243889_-|preprotein-translocase-subunit-YajC
MIPLALAALLIFFLFNSRRKQKARAEQIKSGLMPGATVMTTFGVFGTVLSIDEENNQVTIESGPGTVLRVHRQAIGQVESNQAAESADAPGAAAPAADADNDADASDEKPAITDAELDAMNERKRAETDTPDDAAEDVTSDDAAAKTEDVDAEDIAETDGDSADADVDSTDSTDSSDSDTDKKN
>NZ_CP014869.1|WP_062861745.1|2241148_2243263_-|protein-translocase-subunit-SecD
MRFLWLTIITLVLAAIIAGGVIWSNATTTPKLALDLEGGTSIILEPQVSKGTDISKEQLDQAVAIIRQRVDSTGVSEAEITTQGDRNIVVNLPGNPDEETRNLVRSSAQLVFRRVALVGDPRSQEQIQKEQEKNGEEKSGADDGLSDEERKRLEDLTGADSKGDAQGEEQAPSGGGDVVNAGGSAEKKTKEASEKTKSSESAAKDAEKSGEGSDSSDDTKVTDSTPRPLFDPEKDAAEWQTDKIIKEYTELDCTNKKNRTGGQQKPSDEPVVSCSEDGQAKYILGPVELSGDHLADANAGYAAGANGVQTNNPAVNLSFDATGREIFKQITSDITGKQQPYNQFAIELDGLVLSAPSSNAVITDGNAQITGNFSLDEAQTLANQLKNGSLPLSFQVQSEDQISPTLGSNYLKIGLLTGLVGLLLVVVYSLLQYRVLGLVTVSSLVVAGVLTYLLLLLASWRYGYRLSLAGVAGIIIGIGMAADSFIVYFERVRDELRSGRNLLSAVEVGWDRAKRTIYASKAVNMLAAVILYILAVGSVRGFAFTLGLTVIIDVLIVFLFTHPMLQVLARTKFFGEGHPMSGMDPRLLGVKPAAYRGALNLSIDDKDKSPEAKRREKARRRKAGITDPDSETTDTTASESEKTSTKSTTEKTKTAKSKNAKSKTAKTATATGAMTIAERKAAARRAEEDDAAEDSATDGKEADK
>NZ_CP014869.1|WP_062861751.1|2254912_2255275_+|TIGR02611-family-protein
MLANAHTAAIYRSIVGGLGTIIVLVGLALVPLPGPGWLIVIIGLFIISSEFHWAQRLLHFVRVNVERWTHWIMAQRLWVRWTVGAATAAFVGIVVWCTLRLTGLPDWVPDLRVLDLIGLR
>NZ_CP014869.1|WP_062861752.1|2255405_2256413_-|cell-division-protein-ZapE
MNAEQTLVALSDRSPQVAPEELIEGLVPPPQFEDVSFDSYRTDPAEPSQEEARNKLREFTQRSTSQGFLGKLFSKGKSSAKGVYLDGGYGVGKTHLLASAWHANEKPATFGTFVEYTNLVGALGFARARDDLSKMKLVCVDEFELDDPGDTVLMSRLMRELTDAGVKIIATSNTLPGALGEGRFAAQDFLREIQALSDQFEVYRIDGKDYRARELTAPADPLPEAELDAAASELVGVVARDDFSALLEHLSTVHPSRYGRMVDGIDGAVWENVRTIDNESVALRFVALVDRLYDRNVHIINSGAALDKVFTEESLAGGYKKKYMRCLSRLTALSS
>NZ_CP014869.1|WP_062861753.1|2256512_2257451_-|GTPase-Era
MEFRTDYPEDYRAGFACFVGRPNTGKSTLTNALVGEKVAITSAKPQTTRHTIRGIVHKDDHQLILIDTPGLHKPRTLLGSRLNDLVASTLGEVDVIGFCLPADEPIGPGDRYIASQLSLLDGRTPIVALVTKVDRVPKDKVAEALMAVGELADFADVVPVSAVEDFQVDTVDSVLAAHLPKSPPLYPDGDLTDEPEEKMIAELVREAALEGVRDELPHSLAVQVEEMYPREGRSEDNPLWNVHVNLYVERPSQKAIIIGKGGSRLKAIGSESRQGIERLLGTKVYLDLHVKVAKDWQRDPKQLGRLGFDFNN
>NZ_CP014869.1|WP_156483875.1|2257452_2258766_-|DUF21-domain-containing-protein
MFMFFLGAALCLIIAATLSAVDAALLNVSHHAVEEAEEDGKRAAVRVERILADLPTNINVIIFVRNFLEALATVFIALAYDSYYSVGPLMVFLTVLTASVAVFIIAGVSPRTIGKRRSLAVSLNLSWVVRIVLVALKPLTRILVVLGNLLTPDKVYKDGPFVTSEQLRDLVERASESDIIEDGEREMIQSVFNLSDTSANEVMVPRTDLVTVDAEVSLQKAMSLFFRSGFSRIPVCGEDLDDVRGVAYLKDVARRLYLHPEEGDRPVGNLARSVLFVPETKPADDLLRQMQLDSTHLAILVDEYGGTAGLVTIEDIVEEIVGEIEDEYDNGDDELVAADDGSFIISTRMSISDFAEYFDVRIDEDDVNSVGGLLSKLIDRVPIDGSHAEIEGLEIEAMEGQGRRHRITHVRVTRTHEDNRDEAQTVAADGSGTKEED
>NZ_CP014869.1|WP_062861755.1|2258768_2259257_-|rRNA-maturation-RNase-YbeY
MNTEILNETDAEVDLDEVVALTEYLGEALHMHPGAELAVTMVDSSAMSELHVTWMDLEGPTDVMSFPMDQLHQGEPDSPAEGQMGDIIICPEVAEAQAGAAGHSTMDEILLLTVHGFLHLLGYDHGEPEAREEMFALQRHLLLTFFAARYDGRTDIPTPTEV
>NZ_CP014869.1|WP_082819361.1|2259253_2260288_-|PhoH-family-protein
MNPTDSDTAAAGDGAAVNDAVTDPRGAERDTVRLVIPDSIDLVAFFGPGESNLRALEKTFDDLDIHVRANQVQVTGDPKRVESFVSVIGELKKLHTAGHRINEETIDRVTTFSSEGAAASAVLGTNILSTRGKSIRPKTMGQHDYVKAIRNHTITFGIGPAGTGKTYLAMAMAVNALQHKEVSRIILTRPAVEAGESLGYLPGTLNDKIDPYVRPLYDALHDMVDPESIPLLIETGTIEVAPLAYMRGRTLNDAFIILDEAQNTTAEQMKMFLTRLGFGSRMVVTGDISQIDLPGKTRSGLKVVRDILDGIDDLQFCELGSKDVVRHSLVTKIVEAYDLWGSAE
>NZ_CP014869.1|WP_062861756.1|2260388_2261150_-|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MSLPVFRSATAAEAVVGSALTLGEDVAGHAVRVRRIGPGEEIEIVDGDGTRVRGTVTAASANELTIDVTAVTNEEHTGPRLVLVQALAKGDRDLQAIETATEIGVDDVIPWAAERSIADWPAKKREKMAAKWENLLGAASLQARRSRVPVLHELVRGAALAKAFDETDAVFVLHETAQRRLSEALADLTADGSSRLPERIVFVVGPEGGISDGELDALTGRGATPVLLGPTILRSSSAGSAGLVMAQNSLGRW
>NZ_CP014869.1|WP_039207369.1|2261146_2262262_-|molecular-chaperone-DnaJ
MADHYETLGVSKDASAAEIKSSYRKLARKYHPDVNPGHEDEFKAISLAYDVLSDPEKRRNYDMGGGENGQGFPAGGGFGGFGDIFETFFGGGGGQAGGPIPRTQRGKDALVGVNIDLKTAAFGGTVDLDVTTAVVCDTCSGAGTQEGTKIETCSLCHGAGSVQRMTRTLLGQMVTNQTCNSCHGFGTVIPNPCLNCQGDGRVRKQRTMKIRIPAGVSDGTRIQLSSQGEVGPGGGPAGDLFVEVMVTRHEVFQRDGDNLRAAVSVPMTAATLGATIPFETFDGTQDLNIAAGTQSGTVVKLSGLGATRLRSETRGDLLITVDVLTPDKLDDEQRELLEKLAELRGEETPRAQISTENRGMFSRMRERFAGR
>NZ_CP014869.1|WP_062861757.1|2262388_2263429_-|heat-inducible-transcriptional-repressor-HrcA
MNDSRRAQVLRAIVEDFVATNEPVGSKAIVQRHTLGVSPATIRNDMAQLEQEGYIAQPHTSAGRIPTDLGYRMFVDRIDEFKPLTTAERRAIFQLIDGDVELDEMLDRTVRVLSGLTRQVALIQYPTVARARIKHIEVVGLGPGRILVVLITDAGQVEQKSVITPTPLDEDAVRGLRDQINAEFAGRTLAQIFGSSPTTEAVATEPSEPAVRDDSGLTQVRAAVVDLVAATREERIIMAGTANLARSGSEFGEKMAPILEAFEEQVVLLKLLTSMAEDHEGISVRIGRENTHESFSSTSVVAAEYGHDAGSSARLAVLGPTRMDYPTTISAVRAVAKYVSSILDRG
>NZ_CP014869.1|WP_082819362.1|2263609_2264473_+|DUF3097-domain-containing-protein
MPVNAFDRYGPDVLSGSSPSSHRPKKSRQVELGLGMVLEDAMSGYVGAVVGAEKTTAGVVVKLEDRVGKVRVFPLGPGFLLEGQPVDVQLPKKNPQQPGRTASGSRAVVGAKARVARGSRIWVEGKHDAELVEKIWGDDLRIEGVVVEPLGGLDDVADKLEAFGPDREHRVGVLADHLVHGTKESRIAEAVRADPRYRDVVHIIGHPYVDIWQAVKPHVVGIREWPVVPRGEDWKTGILRRIGWPHADHRDVARGWVRILGKVSTIADVEPTLSGRVEELIDFVTVG

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Crispr_ID: NZ_CP014869_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014869_2

2433166-2433272

Orphan

Consensus_repeat	Method
GGAACTTCGGTTGCGTATGTGCAGTCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP014869_2

>merge|NZ_CP014869|2|2433166-2433272|CRISPRCasFinder
GGAACTTCGGTTGCGTATGTGCAGTCCGGAGGGTGCTCAATCGTGATTGTTCAGTCCCGCGGGTCTGCCTGGTCGTGGGGAACTTCGGTTGCGTATGTGCAGTCCGG

>NZ_CP014869|2|2|2433166-2433272|CRISPRCasFinder
GGAACTTCGGTTGCGTATGTGCAGTCCGG	AGGGTGCTCAATCGTGATTGTTCAGTCCCGCGGGTCTGCCTGGTCGTGG
GGAACTTCGGTTGCGTATGTGCAGTCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014869.1\|WP_062861834.1\|2436955_2437615_-\|(d)CMP-kinase	unknown	unknown	gnl\|CDD\|236546
NZ_CP014869.1\|WP_039208294.1\|2431575_2432349_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213186
NZ_CP014869.1\|WP_152609616.1\|2440277_2441063_-\|segregation/condensation-protein-A	unknown	unknown	gnl\|CDD\|224273
NZ_CP014869.1\|WP_062861832.1\|2427174_2427918_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187594
NZ_CP014869.1\|WP_062861831.1\|2425923_2427123_-\|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl\|CDD\|180843
NZ_CP014869.1\|WP_062861829.1\|2421171_2422488_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240541
NZ_CP014869.1\|WP_039208287.1\|2435447_2436959_-\|ribosome-biogenesis-GTPase-Der	unknown	unknown	gnl\|CDD\|179525
NZ_CP014869.1\|WP_062861835.1\|2437611_2438760_-\|prephenate-dehydrogenase	unknown	unknown	gnl\|CDD\|235824
NZ_CP014869.1\|WP_062243177.1\|2438756_2439617_-\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108
NZ_CP014869.1\|WP_039208301.1\|2429666_2430533_+\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119324
NZ_CP014869.1\|WP_062862866.1\|2434100_2435243_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|183405
NZ_CP014869.1\|WP_039208292.1\|2432348_2433053_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223487
NZ_CP014869.1\|WP_062862867.1\|2441179_2442049_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|379293
NZ_CP014869.1\|WP_062861838.1\|2442087_2443038_-\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|234713
NZ_CP014869.1\|WP_062861833.1\|2428366_2429581_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380559
NZ_CP014869.1\|WP_039208289.1\|2433347_2433974_-\|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl\|CDD\|183245
NZ_CP014869.1\|WP_082018872.1\|2420428_2420635_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP014869.1\|WP_167556064.1\|2424921_2425791_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|238038
NZ_CP014869.1\|WP_062861836.1\|2439634_2440288_-\|SMC-Scp-complex-subunit-ScpB	unknown	unknown	gnl\|CDD\|377219
NZ_CP014869.1\|WP_064485793.1\|2430529_2431579_+\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119323

Protein	Function_ID	Function_description	E-value
NZ_CP014869.1\|WP_062861834.1\|2436955_2437615_-\|(d)CMP-kinase	gnl\|CDD\|236546	PRK09518, PRK09518, bifunctional cytidylate kinase/GTPase Der; Reviewed.	7.26828e-67
NZ_CP014869.1\|WP_039208294.1\|2431575_2432349_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	4.05644e-111
NZ_CP014869.1\|WP_152609616.1\|2440277_2441063_-\|segregation/condensation-protein-A	gnl\|CDD\|224273	COG1354, scpA, Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair].	1.54677e-36
NZ_CP014869.1\|WP_062861832.1\|2427174_2427918_-\|SDR-family-oxidoreductase	gnl\|CDD\|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	2.64956e-99
NZ_CP014869.1\|WP_062861831.1\|2425923_2427123_-\|acetyl-CoA-C-acyltransferase	gnl\|CDD\|180843	PRK07108, PRK07108, acetyl-CoA C-acyltransferase.	0
NZ_CP014869.1\|WP_062861829.1\|2421171_2422488_-\|MATE-family-efflux-transporter	gnl\|CDD\|240541	cd13136, MATE_DinF_like, DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.70796e-98
NZ_CP014869.1\|WP_039208287.1\|2435447_2436959_-\|ribosome-biogenesis-GTPase-Der	gnl\|CDD\|179525	PRK03003, PRK03003, GTP-binding protein Der; Reviewed.	0
NZ_CP014869.1\|WP_062861835.1\|2437611_2438760_-\|prephenate-dehydrogenase	gnl\|CDD\|235824	PRK06545, PRK06545, prephenate dehydrogenase; Validated.	1.36965e-114
NZ_CP014869.1\|WP_062243177.1\|2438756_2439617_-\|rRNA-pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	1.31137e-88
NZ_CP014869.1\|WP_039208301.1\|2429666_2430533_+\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	4.67665e-73
NZ_CP014869.1\|WP_062862866.1\|2434100_2435243_-\|AI-2E-family-transporter	gnl\|CDD\|183405	PRK12287, tqsA, pheromone autoinducer 2 transporter; Reviewed.	2.4732e-43
NZ_CP014869.1\|WP_039208292.1\|2432348_2433053_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	8.55214e-113
NZ_CP014869.1\|WP_062862867.1\|2441179_2442049_-\|ParA-family-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	1.06356e-85
NZ_CP014869.1\|WP_062861838.1\|2442087_2443038_-\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|234713	PRK00283, xerD, tyrosine recombinase.	9.1247e-129
NZ_CP014869.1\|WP_062861833.1\|2428366_2429581_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380559	cd06336, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.	6.21137e-98
NZ_CP014869.1\|WP_039208289.1\|2433347_2433974_-\|threonylcarbamoyl-AMP-synthase	gnl\|CDD\|183245	PRK11630, PRK11630, threonylcarbamoyl-AMP synthase.	7.9619e-84
NZ_CP014869.1\|WP_082018872.1\|2420428_2420635_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.95093e-10
NZ_CP014869.1\|WP_167556064.1\|2424921_2425791_+\|HNH-endonuclease	gnl\|CDD\|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	4.70682e-10
NZ_CP014869.1\|WP_062861836.1\|2439634_2440288_-\|SMC-Scp-complex-subunit-ScpB	gnl\|CDD\|377219	pfam04079, SMC_ScpB, Segregation and condensation complex subunit ScpB. This is a family of prokaryotic proteins that form one of the subunits, ScpB, of the segregation and condensation complex, condensin, that plays a key role in the maintenance of the chromosome. In prokaryotes the complex consists of three proteins, SMC, ScpA (kleisin) and ScpB. ScpB dimerizes and binds to ScpA. As originally predicted, ScpB is structurally a winged-helix at both its N- and C-terminal halves. IN Bacillus subtilis,one Smc dimer is bridged by a single ScpAB to generate asymmetric tripartite rings analogous to eukaryotic SMC complex ring-shaped assemblies.	3.61795e-56
NZ_CP014869.1\|WP_064485793.1\|2430529_2431579_+\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119323	cd06581, TM_PBP1_LivM_like, Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	6.25681e-79

>NZ_CP014869.1|WP_039208292.1|2432348_2433053_+|ABC-transporter-ATP-binding-protein
MLTLDNVSTGYDATNVLHGVSITAQPGELTVVLGANGSGKTTLFKTISGLMRVRAGSIDYEGRQLHRARPNAIVKAGIAHCPEGRHLFGKMSVEKNLRLGSYPHRNSSRTEEIYAEVLDMFPILKEKAKQPAGSLSGGQQQMVAIGRALMSDPSLLILDEPSMGLAPIIVEQVLESVAQINRNGIGVLLSEQNAKASLAIAHKGYVLAEGRIVLADEASRLLDNPEVQAAYLGL
>NZ_CP014869.1|WP_039208294.1|2431575_2432349_+|ABC-transporter-ATP-binding-protein
MTLLEIRGLGKRFGGLDAVKDVSLDVEEGQITAVIGPNGAGKSTLFNLVHGFYRPTAGAISFKGEDITHSSPHRTVAGGIARTFQTTNLFDDSTLLENVLAGRIVRSKSNVFDAVFHTPRHRRESRINEDKAMEALEFCGVAEYRHDLASNVPQEVQKRTAVAMALATEPELLLLDEPAGGIPEEETVDFGNLIRSLPQQGVSVLLVEHKMTMIMGLADTILVLDHGQKLALGSPAEIQSNPDVIRAYLGSTAEEEN
>NZ_CP014869.1|WP_064485793.1|2430529_2431579_+|branched-chain-amino-acid-ABC-transporter-permease
MSPMKNPRIIGTIAVIILLGLTPLAFAQENYTMRVITVGMCAAIAVYGLNIILGFTGQLNLAQGGFFGIGAYGVGLLTTDYDWSFWAAFVASVIGTAVIGYLCGLLALRTKDEYFAIFTMAIGFIIFLVISRWESVTHAHSGVNNVKFPEGGGIIDFESPVAMFYLVFAVLLVCVYTTYAIRRSSVGRTLLTIRTSEDLADAVGVRVGFSKQLAFAASAVFGGVGGGLYATVVGFIGPDSASIDKTFEFLMFILVGGMGTVAGPLLGSMIVTFLFELFQDFQAYRFIVLGPIIVALVIFAPRGIVGYLGGFVDKRNRRRRSAEARRSEHDESAPSDSAAAVGTNSEEKK
>NZ_CP014869.1|WP_039208301.1|2429666_2430533_+|branched-chain-amino-acid-ABC-transporter-permease
MTLFIQQLFNGLALGGVYCLAAIGLTLVFGVLRIPNLAHGALYMLGAYITYFFLTTVGVPYIAAIGIAAIALFVVGVGLERLVFHPLRNSPHTHHMIAAVGAMFFFQALAQAIWGADFRRMDTPITGGLQIFGAEISAQRIVIIVTAVIVLALLALFIKRSIHGQTIEAIEQDRVGASLVGINPSMVSMLTLGLSALLATIAAGLVAPINLLSPTMGDALNLKVFAIIILGGLGSLPGAIVGGFALAIAETMTATYISSAVGETVAFVVLVAVLAIKPNGLFTKAVQR
>NZ_CP014869.1|WP_062861833.1|2428366_2429581_+|ABC-transporter-substrate-binding-protein
MNSVSQSRRRRLSAAAVLGAIALTATACGGGGGSGEGDTVVIGYTGPLSGGGAAYGENVKVGLEMVIDDLNADGVEVDGNPVTLELKSLDDKYAPSTAASNAQRLADQDKAPVVVSPNAGAIKAIQQINSGRSNFLISAYTSDPAIMQADNPLTMMIPPNFESYADEFSETAMEHGGKKLALLGTESEYGQQWTKSIKDAWSEAGGKIGGDNSVDYATVSDFAGPVSKALSEKPDAIFVGGPSQPTALIMEEARKQGFKGSFLVMDQAKLDEMATVTKIDNLKNSVGVLPVSEYEDPGTKDFLKKFAEKAGEKKVPTSETALNYQGIAIIAKAMEVAGTTDDPEKIREAIGQALPEVDDKYKVNGFPDEITEQGHLLNPNLEATFLDEDGKYTKVPIEQVSDDK
>NZ_CP014869.1|WP_062861832.1|2427174_2427918_-|SDR-family-oxidoreductase
MTRTAIVTGGGRGIGAAIAKRLGADGLKVAVLDMGPTGETVAAIKDAGGEALGLEADVSDEDSVNAAVKQVAETLGAPTVLVNNAGILRDNLLFKMTYEEFNKVLSVHLGGAFLMAKAVQSYMVEEKFGRIISMSSTSAQGNRGQTNYSAAKAGIQGITKTWAIELGKFGITANAIAPGFIETDMTKATAERVGMDFDEFVEASAKQIPVARSGKPEDIAHTASFLASEGAGFVSGQVIYVAGGPKD
>NZ_CP014869.1|WP_062861831.1|2425923_2427123_-|acetyl-CoA-C-acyltransferase
MREAVIVSTARTPIGKAYRGAFNDTQAQELAGHAIKHAVERAGLEGGEVEDVILGAALQQGSQGSNVARQAALRAGLPTTVPGMSIDRQCSSGLMGIATAAKQILFDDQEIVVGGGVESVSLVQNDKMNTFRAKDPWLDEHVPGIYYPMLATAEVVAERYGISREAQDEYSLSSQQRTAAAQEAGRFDAEIVPLPTTKVVVDKETKETSRQDVVLEADEGNRPSTTLESLAGLNPVLDPGVASKVPSITAGNASQLSDGASASVVMSSDEASRRGLEPMGIYRGMAVAGCEPDEMGIGPVFAIPKLLKNHGLSIDDIGLWELNEAFAVQTLYCRDRLGIDPEKYNVDGGGISVGHPYGMTGARLVGHALIEGRRRGVKYVVVTMCIGGGQGAAGLFEVC
>NZ_CP014869.1|WP_167556064.1|2424921_2425791_+|HNH-endonuclease
MLPNGSPIPAEMARRVAGYSTTWTRLLTDPATGTPVDAKATSYAIPNSVRKTLVAQFMTCTFPGCTQPAEVTEVDHIDPFNHSDPTQGGLTRFGNLHCLCKAHHLQKTNGNFDVRMAEPGHLEYVFRKGVTAEVVSPDNPISIEHARLFLERFGARLPRTGRAVTSEQANIEDPLADESVPATEHQSDAEGDPDVERQSDSETASAHNSGDPNVKHPVPGVRKQAQECPEPAATDRSPGWREFIANDPDAFAPKTAPRSADEASGTARSGKDDAELRNWFWDSGEPPPF
>NZ_CP014869.1|WP_062861829.1|2421171_2422488_-|MATE-family-efflux-transporter
MAAIDKDILRLALPALGALIAEPIFLLTDTAMVGHLGAGALGSLAIASTILQTVLGLMIFLAYATTPRVAKRMGSGDRPGAITAGFDGIWLALGTSILLIIIGLPLLSTAIGAFDPDPAITEGAHSYLAISWWGLPFMLMVIAATGLLRGLQDTKTPLIVAAAGCIANIGLNAFFIYGLDMGVAGSAMGTVIAQAGMCAVYLTISIRAARRLHASIRPDWSGVFTSAKTSGWLLVRNASLRAALILLVFLATAMGTTDLAAIQVAQSIFFALALALDSLAIAGQAMIGLELGAKNTDAVAAINRRLCLWGIIFGIVVGVVLFAGSGIIPRAFASDPAVVSALAALLPVLALSMPIAGYVFVLDGVLMGAEDAKYLALAQLVAVIGYAILLIPIINIWPGAPGLWAGFCIGFVGFRALTLGWRVRNRAWIERAVEKGIS
>NZ_CP014869.1|WP_082018872.1|2420428_2420635_-|GNAT-family-N-acetyltransferase
MAVLPDHQGQGIGGALLDTICALARMSGYPAVSLSVEDGNGAAKLYADHGFVSVGRNGDSDVLVRKLG
>NZ_CP014869.1|WP_039208289.1|2433347_2433974_-|threonylcarbamoyl-AMP-synthase
MATLLNIHPENPQDRLIEKAAESLRNGGLIAYPTDSCYALGCALDNKEGIERITRIRHLGSKHHFTLMCHDFAQLGQFVIVDNSDFRAIKSMTPGPFTFIMKATKEVPRRMMHPKKHSVGARIPQNVTALALVEAMGEPILSSTLLLPGDEDPLTHAEDVMDQLGNDLDIVIESGVPGVVPTSVIDFTGKYPEVARVGAGDVSRFADE
>NZ_CP014869.1|WP_062862866.1|2434100_2435243_-|AI-2E-family-transporter
MVESASAGAEPDLADEARPWHSRQPARALMIAVTLAGLAYALMFFRGLQDIVAPVFLALNFYIVVYPVQRLLTRIKVPRAIGACISVGLVLCMIFAFFGLTAWSVAELVILIPSYSNELVDTYQNTLAMLSDIGVTSSVIQQQLKAFDVRSVLDAVYPLLTNLSSVAGLLTTVIMAVFFVAMDSMGIDKRMKMLLDVKPTLSASIGDFASGVRRYWVVATIFGLIVALLDVIALAIIDVPLIWVWGVLAFLTNYIPNIGFVIGLVPPALLALVDSGWQSALWVVIAYSVLNFVIQAIIQPKFTGESVGVTPLISFLSLLFWVWILGWLGALLALPATLLIKALLVDADPKARWVNILLASDPGTARAELVKGLKKPEAAV
>NZ_CP014869.1|WP_039208287.1|2435447_2436959_-|ribosome-biogenesis-GTPase-Der
MSESEFHETPDEDLVERVESISDEEAEQRATALEAGLESYELEDEDRALLRAYGFEEDEDEALGAAPVLAVVGRPNVGKSTLVNRILGRREAVVEDVPGVTRDRVSYRAEWNTKEFTLVDTGGWDQDSKGMASRIAIQSEVAVDMADAVLLVVDATTGPTSTDEMVVKMLRRKKKPVLLAANKVDDERGELMAAELWGLGLGQPWTVSALHGRGVADLLDEVLTILPEVSAVDTRVEEGGPRRVALVGRPNVGKSSLLNQLIGSDRVLVDNVAGTTRDPVDELIELGDKQWRFVDTAGIRRRAHQASGADFYAALRTQTALERAEVALVLMEVQDPLSEQDVRIVTTAVEAGRAVVLAFNKWDLLDDERRFYLEREIERDLGHVAWAPRVNISAKTGRHAEKLVPAMEAALEGWDTRIPTGRLNAFLGELVAANPHPVRGGKQPRILFGTQAQSRPPKFVLFTTGFLDPGYRRFIIRRLRETFGFKGTPIEVSMRIREKRRGR
>NZ_CP014869.1|WP_062861834.1|2436955_2437615_-|(d)CMP-kinase
MSVVAIDGPSGVGKSSTAKEVARRLGYQYLDTGAMYRAMAWLCLNRGVTDPVDVLEQVRGADLEISLSADEFFVSVDDIDVTEEIRGEEVSANVQTVSGVIDAREELIEMQRAYITAAPEGIVVEGRDITTVVAPDADVRILMTARDEVRVARRAKEVHGNADAEAIAATQDLVTGRDAKDSATTSFLEAADGVFTLDTSDIDFDQVVETVLQLVKDSQ
>NZ_CP014869.1|WP_062861835.1|2437611_2438760_-|prephenate-dehydrogenase
MRVHIIGTGLLGASLGLALSAKGHQVTLEDTSPTAQQLAADLGAGQVVTPKATNAEAADPTAGTDASSPASHPDIVVVATPPDVAARVIASALEDYPNATVTDVASVKTRLLEAVRELATGTQLDRYIGCHPMAGREKSGAIAAQSDLFTARPWVICSDEDTPADRLGDVIAMAEDTGASVLHLDPRIHDAAVAKVSHVPQVVASLVASQLRHAPLEEISLAGQGLRDVTRIAASDPGLWTQILTGNAEEVRSVLVDLRTELDEVISALELGPGSTGLLAKAIALGNEGHDRIPGKHGQPPTTYAVVTILVPDTPGTLARLFKDIGDLGVNVEDFRMDHASGRKLGMVDVSVVPAIQQELEIGLLSKGWQIPESAIEKEGTA
>NZ_CP014869.1|WP_062243177.1|2438756_2439617_-|rRNA-pseudouridine-synthase
MSPYRDHRAPGGRQNRPSRKQRAMTAKQASNKGGTGAGQTSDAHVSGGVRLQKVLAEAGLGSRRACEQLIVDGRVEVDGSIVTELGTRIDPETQSVYVDTVRISTQTKKVYLVLNKPAGVVSTMSDPEGRPCLADYVRNNTERLFHVGRLDTETEGIILLTNDGELSNRLAHPRYEIPKTYVAKVKGQLAKDAGAILKAGIDLEDGFVKVDDFKLVDSTPGKSVVELTLHSGRNRIVRRLLAEIGHPVERLVRLKFGPIVLDEQKQGKIRPLRSDEVGALFEAVGL
>NZ_CP014869.1|WP_062861836.1|2439634_2440288_-|SMC-Scp-complex-subunit-ScpB
MIDDEILAGIEAVLMITDSAVTAEDLAGSLGLDEDTVLEAIRTLKTDYDGDENHRQRGFEIRHVAGGFRIFSRGDYHEVVKDFLTAGQSAKLSQAALETLAVIAYRQPISRPRIAAIRGVSVDGVIRTLLLRGLIVEAGKEASTSALLYATTPTFLDTMGMNAIDDLPDIAPYLPEDADVAELGAEDTEVLAEIDGALDDDLDDETDSSAEMSRVAD
>NZ_CP014869.1|WP_152609616.1|2440277_2441063_-|segregation/condensation-protein-A
MLLGLISKRRLDVTEIALAEVTDEFIAYTTELKDQANLAEISQFLLVAATLLDLKTARLLPHEEGEEVLDLELLEARDLLFARLLQYKAYKSVSGYLAEAMAAGSIRAPRDVDLEPEFQDVLPPLELNIGPGELAGIFATVLQRDHTPPSVAVDHIHLPLVSVSEQRGHILSLLRAGDVDFQDLLETAENTLVVVARFLALLELFKVGLCDFDQPEPLGRLLIHRTEMNEDGVDLRTEGDWSGDEDDNQAANDDGGVQNDR
>NZ_CP014869.1|WP_062862867.1|2441179_2442049_-|ParA-family-protein
MNTQEALEIPQQRTAAAEPQDFPEPAPLDSHGPARIIAMVNQKGGVGKTTSSINLGAALAAYGRKMLLVDFDPQGALSVGLGLNPYELDISIYNLLMNPRLDPHEVIVETDFENIDILPANIDLSAAEVQLVGEVAREQVLARALSKVADEYDVILIDCQPSLGLLTVNALTAAHGVVIPLETEFFALRGVALLVETIEKVQDRLNPSLEVDGILATMFDSRTLHSKEVMSRVTEAFGNKVFETVINRTVKFPDASVAAEPITSFAPKHAGSEAYRRLARELIARGGAP
>NZ_CP014869.1|WP_062861838.1|2442087_2443038_-|site-specific-tyrosine-recombinase-XerD
MARHGAELLPEDLSEDLRRAFESYLASLRFERGLSMNSIDAYARDLARYGTWLTEDGVSRLGEVDRQKVESYALHLLDSGLAPRSRARALVAVRRFHTFALGENLASTDPASEVSPPQEGLRLPKALALDDIEAMIATTDGEEPAQIRAAALLELLYATGARISEAVGVDLDDLDLDSGLVRLYGKGGKERIVPFGSHAARALGAWVSRARPSMAAKAKSSAPAGALFLNARGTRLSRVSAWQIVKDAGKAAKIDAEVSPHTFRHSFATHLLEGGADIRVVQELLGHASVTTTQIYTKVSEETLREVYATSHPRAR

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Crispr_ID: NZ_CP014869_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014869_3

3402624-3402726

Orphan

Consensus_repeat	Method
CCCCGCCGAGGCGGCCGGACCGTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP014869_3

>merge|NZ_CP014869|3|3402624-3402726|CRISPRCasFinder
CCCCGCCGAGGCGGCCGGACCGTTGCCTGCGGAAGCGGAGTTGCCTGCAGACGCGGGGTTGGCGGCGACGCCGCCGTTCCCCGCCGAGGCGGCCCGACCGTTG

>NZ_CP014869|3|3|3402624-3402726|CRISPRCasFinder
CCCCGCCGAGGCGGCCGGACCGTTG	CCTGCGGAAGCGGAGTTGCCTGCAGACGCGGGGTTGGCGGCGACGCCGCCGTT
CCCCGCCGAGGCGGCCCGACCGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014869.1\|WP_082819589.1\|3397591_3398278_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP014869.1\|WP_062862432.1\|3405724_3406528_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|379138
NZ_CP014869.1\|WP_039208416.1\|3392369_3393458_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NZ_CP014869.1\|WP_062241246.1\|3399653_3400049_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP014869.1\|WP_062862426.1\|3387837_3388986_-\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|226614
NZ_CP014869.1\|WP_062862427.1\|3389071_3392080_+\|aminopeptidase-N	unknown	unknown	gnl\|CDD\|341065
NZ_CP014869.1\|WP_052239887.1\|3410362_3411355_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP014869.1\|WP_062862433.1\|3407724_3409380_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NZ_CP014869.1\|WP_062862428.1\|3393728_3394814_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274646
NZ_CP014869.1\|WP_082819462.1\|3413512_3415000_-\|diaminopimelate-decarboxylase	unknown	unknown	gnl\|CDD\|143505
NZ_CP014869.1\|WP_082018849.1\|3409379_3410363_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP014869.1\|WP_082819461.1\|3406619_3407732_-\|LD-carboxypeptidase	unknown	unknown	gnl\|CDD\|132882
NZ_CP014869.1\|WP_167556066.1\|3411508_3413311_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173853
NZ_CP014869.1\|WP_062862434.1\|3415098_3416985_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NZ_CP014869.1\|WP_082819460.1\|3400374_3401844_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP014869.1\|WP_052239862.1\|3398549_3399578_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223566
NZ_CP014869.1\|WP_062862431.1\|3401913_3402615_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NZ_CP014869.1\|WP_082819588.1\|3394931_3395882_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|238038
NZ_CP014869.1\|WP_062862951.1\|3403995_3405153_-\|DUF819-domain-containing-protein	unknown	unknown	gnl\|CDD\|227792
NZ_CP014869.1\|WP_039208407.1\|3405285_3405597_-\|DUF3870-domain-containing-protein	unknown	unknown	gnl\|CDD\|372419

Protein	Function_ID	Function_description	E-value
NZ_CP014869.1\|WP_082819589.1\|3397591_3398278_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.35677e-16
NZ_CP014869.1\|WP_062862432.1\|3405724_3406528_-\|serine-hydrolase	gnl\|CDD\|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.39338e-39
NZ_CP014869.1\|WP_039208416.1\|3392369_3393458_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	3.48069e-32
NZ_CP014869.1\|WP_062241246.1\|3399653_3400049_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.49298e-17
NZ_CP014869.1\|WP_062862426.1\|3387837_3388986_-\|FUSC-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	8.39406e-16
NZ_CP014869.1\|WP_062862427.1\|3389071_3392080_+\|aminopeptidase-N	gnl\|CDD\|341065	cd09602, M1_APN, Peptidase M1 family including aminopeptidase N catalytic domain. This model represents the catalytic domain of bacterial and eukaryotic aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	0
NZ_CP014869.1\|WP_052239887.1\|3410362_3411355_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.25716e-117
NZ_CP014869.1\|WP_062862433.1\|3407724_3409380_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	0
NZ_CP014869.1\|WP_062862428.1\|3393728_3394814_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	8.06052e-117
NZ_CP014869.1\|WP_082819462.1\|3413512_3415000_-\|diaminopimelate-decarboxylase	gnl\|CDD\|143505	cd06836, PLPDE_III_ODC_DapDC_like_1, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Uncharacterized Proteins with similarity to Ornithine and Diaminopimelate Decarboxylases. This subfamily contains uncharacterized proteins with similarity to ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC). ODC and DapDC are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. ODC participates in the formation of putrescine by catalyzing the decarboxylation of ornithine, the first step in polyamine biosynthesis. DapDC participates in the last step of lysine biosynthesis, the conversion of meso-2,6-diaminoheptanedioate to L-lysine. Proteins in this subfamily may function as PLP-dependent decarboxylases. Homodimer formation and the presence of the PLP cofactor may be required for catalytic activity.	0
NZ_CP014869.1\|WP_082018849.1\|3409379_3410363_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.63802e-90
NZ_CP014869.1\|WP_082819461.1\|3406619_3407732_-\|LD-carboxypeptidase	gnl\|CDD\|132882	cd07025, Peptidase_S66, LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein. LD-carboxypeptidase (Muramoyltetrapeptide carboxypeptidase; EC 3.4.17.13; Merops family S66; initially described as Carboxypeptidase II) family also includes the microcin c7 self-immunity protein (MccF) as well as uncharacterized proteins including hypothetical proteins. LD-carboxypeptidase hydrolyzes the amide bond that links the dibasic amino acids to C-terminal D-amino acids. The physiological substrates of LD-carboxypeptidase are tetrapeptide fragments (such as UDP-MurNAc-tetrapeptides) that are produced when bacterial cell walls are degraded; they contain an L-configured residue (L-lysine or meso-diaminopimelic acid residue) as the penultimate residue and D-alanine as the ultimate residue. A possible role of LD-carboxypeptidase is in peptidoglycan recycling whereby the resulting tripeptide (precursor for murein synthesis) can be reconverted into peptidoglycan by attachment of preformed D-Ala-D-Ala dipeptides. Some enzymes possessing LD-carboxypeptidase activity also act as LD-transpeptidase by replacing the terminal D-Ala with another D-amino acid. MccF contributes to self-immunity towards microcin C7 (MccC7), a ribosomally encoded peptide antibiotic that contains a phosphoramidate linkage to adenosine monophosphate at its C-terminus. Its possible biological role is to defend producer cells against exogenous microcin from re-entering after having been exported. It is suggested that MccF is involved in microcin degradation or sequestration in the periplasm.	2.21021e-88
NZ_CP014869.1\|WP_167556066.1\|3411508_3413311_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	5.64691e-125
NZ_CP014869.1\|WP_062862434.1\|3415098_3416985_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	2.17028e-17
NZ_CP014869.1\|WP_082819460.1\|3400374_3401844_-\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	8.69123e-38
NZ_CP014869.1\|WP_052239862.1\|3398549_3399578_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	3.44807e-47
NZ_CP014869.1\|WP_062862431.1\|3401913_3402615_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	3.27984e-56
NZ_CP014869.1\|WP_082819588.1\|3394931_3395882_-\|HNH-endonuclease	gnl\|CDD\|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	2.20872e-12
NZ_CP014869.1\|WP_062862951.1\|3403995_3405153_-\|DUF819-domain-containing-protein	gnl\|CDD\|227792	COG5505, COG5505, Predicted integral membrane protein [Function unknown].	3.74284e-96
NZ_CP014869.1\|WP_039208407.1\|3405285_3405597_-\|DUF3870-domain-containing-protein	gnl\|CDD\|372419	pfam12986, DUF3870, Domain of unknown function (DUF3870). A family based on the C-terminal domain of 3KOG which shows structural similarity to pore-forming proteins, suggesting it may have a lytic function.	1.01941e-37

>NZ_CP014869.1|WP_062862431.1|3401913_3402615_-|type-1-glutamine-amidotransferase
MTRLLVIVNDIESQPGLLTRWMISENVEFDLRIGGVSTLPKPAELDAYDGLIMLGGGFMPDETDRAPWLADEAELVRHALDTDLPQFGICLGGQLIAHVIGADVRAQTGAPEKGYTRIDTTDEAAADPVFSAIRPRTSFVESHVDRIVALPEEATLLATSEACEFQAFRVGRAWGTQFHPESTRENIERWDAAKLQTLGFDKDTLLEEAMELGPESERDSKALFSAFLAVVRN
>NZ_CP014869.1|WP_082819460.1|3400374_3401844_-|APC-family-permease
MRHSRRIGHGGIVSDKEPTTTIDAGDGQQPETLKRVMGPKLLLLFIVGDILGTGVYALTGKVAGQVGGAGWAPVILAFLIALITAFSYMELVTKYPQAAGAALYTHKAFGVHFVTFLVAFAVLSSGITSASTASNVFAANLVAGFGWDISGTGVMWIALAFLTLIALINLRGVGESVWFNVVLTLIELSGLLLVIVVGFFALGSGDADFSRVMIFETEGDKSVFLAVTGATALAFFSMVGFEDSVNMVEETKDPSVFPKIMLSGLTITGIIYVLVSLVTVAAVPIGVLTESETPLLEVVREGAPGLPIDTIFPFMTMFAVANSALINMLMASRLLYGMAKQDVLPPVFAKVLAGRRSPWVSILFTTLIAFALIFVVSTVLPETVTASLGGTTSLLLLAVFAVVNVAVLLLRKDKSGNPDHFKAPTVLPWIGVITCVFLVGPWARLDELIQYQIAAALVGIGVVLWIITWFWNRSTKGTSTRFRNPEELT
>NZ_CP014869.1|WP_062241246.1|3399653_3400049_-|universal-stress-protein
MTVLVGYVNNPAGHAALDAGIAQAKKDGKELVVVNASRSAQRSDSYRLGEGELKSVNNYLSRADVEFRVLTLGSEYDPAEQILDTATEVGAELIVLGTRKRTPVGKFLLGSTIQKVILDAEAPVLCVKAAH
>NZ_CP014869.1|WP_052239862.1|3398549_3399578_+|NAD(P)/FAD-dependent-oxidoreductase
MTIPTAPENSQPSAPDENPESAQNAFDVAVIGGGAGGLAASIALARSLRSVVVIDAGQLRNSSSAHAHNVLGHEGIRPQDLVEKGRAEAEEYGVTVINATVRQAHNLVSEPNPAEAAPRHRFELTTSAGVEIRARRIIIATGLSDELPDIPGLAEGWGDTVLHCPYCHGYEVRGQRIGVIGTTTMSYHQAMLFSQLSDRVSFIRHNAPAPDSEQEAMLDTLGIEYIDSTVTEVARTESGTVVSLVAGESAGEASTLTFDALTVGTYGRANAELFSQLGGEVVAHPSGMGTYIPTQMAGQTDVPGVWAVGNSADVSAVVVASTASGVMAGAHVNADLIMERLR
>NZ_CP014869.1|WP_082819589.1|3397591_3398278_-|helix-turn-helix-transcriptional-regulator
MAESKESGRRTNRGATGERGTHAADRISDILADGPAPIEAEEAIRQSLAGVGARLRGLRQEQGRTLEEVAELAGMSTSTLSRLESGKRKPSLELLLPLAGVYGLPLDELVGTPPIGDPRIHISPRKFHDQTVLPLSRGAIGVQAFKHIVDGRQTPKLGSLKTHPGFEWVYVIRGRLTLILGDRTMILSAGEAAEFDTRSPHWFGGADDGGVEYLSLFGPEGQRVHMKS
>NZ_CP014869.1|WP_082819588.1|3394931_3395882_-|HNH-endonuclease
MKDGTWTLKGCLDEETGGILNGLLTSRIKTDSQSDEDTCANAAGIDASFADDARPAAESGGESENDLDQEVVDAYTEVLRGDRSDCLDPSLDFTPPQVGANGEIPQGAGVKQDGTLVAMAAEQPSVRRRIYERFSSVIGSIEMNRIKAGAAYALVITAKAEDLANRTGKAVTGAEAPFPIDSAALEGLNGSLFFHLMSEKTKSMALATERRLATEKQLAILASRDQGCTFPGCDTPPGWCEAHHIVPWASNGKTDINNLTLACSAHHHLLDYTDWDCRMLIDGRPAWIPPASIDPAQEPVLHARFIAREIGETLFG
>NZ_CP014869.1|WP_062862428.1|3393728_3394814_-|LLM-class-flavin-dependent-oxidoreductase
MKLSILDLVPVRTGQTTADSFAASKQIIDTADKLGFTRYWVAEHHNMPSIASTMPGPELMHLGQGTQQIRLGSGGVMLPNHAPLAVAELFALLSAVFGDRIDLGIGRAPGTDPITSAAMRGHLGEGRMVDREGRAIDPVEQFPRHVIDTLSLMQPEGMRVPLHGGREHVLKATPAAAPGTQPLPWLLGSSGYSARLAAELGMPYVFANHFASGATTGMKIYRDNFTPGAYGDEPQTFVTANLVVAPTEEEAQLRSEPFMLQMARMRTGGPMEKLHLAGDDVRSVMTDQERMVGEELSNNWIIGDPKSAAAQLEELAERFDVDEIMIQPIAGAMEGEDVREDPGRIQTIELLAAEFLGGVNV
>NZ_CP014869.1|WP_039208416.1|3392369_3393458_-|C40-family-peptidase
MRTKIAVSAALGVGLVFGAGAPALSSNLSSTDAANTSGISADVVPGQELERITDGKIEKGETAYVDVTVATLWTDPKAPRKVDKPALQHPVDLKKWNKNLESTDVRRGLTGKTETQATYGAEVSVLDVKGSWAKVAVTDQKTPKNKKGYPGWMPKKQLVENDRFGNLREDQPRAVVTKPKSELEGIEFTKDTGADVSFNVDLPLIAQDVDDVRVALPGGGAAWIDIDDVDVFDVGDKPEKPSGKDLVKTAKQFDGLRYLWAGVSAYGFDCSGFTYSIFKAHGIDLPRDSGEQAKAGKAVSSSNLKPGDLLFFSTSSGTVHHVGMYVGDGKMIHSPNASKDVYVTDWKKWDTGNEFSGARRIL
>NZ_CP014869.1|WP_062862427.1|3389071_3392080_+|aminopeptidase-N
MTTNLTRSEAQSRTQLLEVDSYSVHIDVSNAETDADTYLSRTVVDFSARFVDSTFIDLIADSVSSVLINGESLSPAEVFDGARVTFPVRAGRNSLTIEAQARYSTSGEGLHRFTDPADGKTYLYTQYEPTDARRVFANFDQPDLKAEFIFTVTAPAHFQVLSNRTEARTEPGDGSAGAVTHYFEPTLKQSSYITCITAGAYEGATDEWTDPRTGQTVQLGAWTRASLVDHLDADDIFGVTKAGLEFFTSEFDYPYPWGKYDQIFVPEYNLGAMENPGLVTFTDNLIFRDKVTDANYESRANVILHEMAHMWFGDLVTMKWWDDLWLKESFADFMGGLALAEATRFTDGWVTFALRRKAWAYTQDLYPTTHPIVADIPDVEAAKLNFDGITYAKGASVLKQLVAFVGREAFFAGSRLYFKRFEYGNTELADFLDCLAEAAPDRDIANWASAWLGTSGVSELSLQLTTSDGSAEASEGSSAVSGGSSSAGSIGFANGGASASAVSAQSGGRGKLVTSSSGARLRSPDASDGSFDAATGAAHEAGSGASGSVEPPRRRSGSEKITGATITQADSAEGTALLRPHTIEIATLGRSGRSIVPLDSFRFEFSTESADVEQLIGRSAGVITLLNFNDLDYARVRLDPESTEAAVTSASRIKDPLSRALVWSALDNAVRDGLMPVQKYLTAYARSLGKESHAGIMAGLSQTALTCIDQWVADRNFDAAIMGLLGAALDALAAAKAGSDAQLHLANLVLALTSRTARCAAGSSAVAMGRGFASQVLAVPVGEEIDRMYAGAPGQSGQVGSAGQSAETSGGTRAGRGADHSTATLPFRGLINDHALRWNALTALVSLGWADQTDIARENHSDPSSSGRLRAETASAALPLPIVKIRAWEAIREAGALSNDVLSAIIAGFIAPSAMPLIEEYVDEYFDGLLGFWMDNSIEIARRLVLGLYPRWSVDEEAVVEKTDAWLAANVDAPAALRRLVIERRDDLARAIFLKSTQSSRH
>NZ_CP014869.1|WP_062862426.1|3387837_3388986_-|FUSC-family-protein
MAETRVSDLPRRGFSVVSHRLRMGLKRVWVNSGQLVQIPIAATAAYAFCVYVLDHPYPFLAAVASAVGIGPVVDRRLRRALEIGIGATFGVLVGEILVNLYGSGIWQLALTLIIGLVIGTILNSGGIFITQIAVQSVYVVVVPASATTMPFPRTLDALTGSVCAILLALLIPRDARKVPRRLAADMLEEVDAVLRMMKRALRDADVTMAGRALERARETQDIIDSWGSSLRISREAAKINARARRHAAEVTRLSRAHTFSDRAMRTMRVIARRVVGVTELGVGKPVIADYVGSLADGAKKLEIALRRGTDRSLAEAALSEAAGTLDPRAKSDWDIHDESMVLLLRTVAVDLLQAAGLTRAEAQSRLPPLAEDADDDGGPVVE
>NZ_CP014869.1|WP_062862951.1|3403995_3405153_-|DUF819-domain-containing-protein
MITDGYLFISLLLAISAALVVADRSGRFKLFKYVPGFVILYIVAALLNTIGVFDHSSGDIDAVGDTLRTALLPAMILLMLFKCDVRQIIKLGPKLLLTFAVTAGSIIIGFIVSYLILHSSLDPEAWKALGALNASWTGGSANMVAVQEVLQAPKNVFGYVLIVDTVLYSFWLLLVFSSVTVSDKFDKWTKADMSKLDFTDKVTAEEEKPMTLSSIFGLIGFALLTSALAIHLGELLPEVGAVIDGTAWTILIVSVLGLAIGSTRFGKAAGSNELATILLYLIIGIIASGSDFTSLAEAPLYLVAGIIVLVVHIVIMLIYAKLSRTELFSIAVASTANIGGIASAPVVAGAFNRQLVPVGVLFALMGTFLGTFLGLWSAQILSGLA
>NZ_CP014869.1|WP_039208407.1|3405285_3405597_-|DUF3870-domain-containing-protein
MSDTIYLTGEAKAPSNNPITSQFGLFYVAFEIEPDTHRILDVDCTATLALTRNFIRSLFVDADITDPGRLIERIQRRYHGSSQKALITAVNNAAKKYREVAAQ
>NZ_CP014869.1|WP_062862432.1|3405724_3406528_-|serine-hydrolase
MMSELKFDGLPGVRFSALAFDVDSGERVFAHNENDELDTASMGKVFLLHTALQMYKDGTLDLEERLHRRPSERVDESGIWYLMEQDDLSIFDVALLIGAFSDNFATNVLIRRVGLENVADQVEKLGYRNSGLHDFLRWPRPAKAPRTLSTGTAAEISDFMSRHAKDEFWDESTNEVFRRWLGAGADTSMVASAFDLDPLAHYNYQRDVWVWNKTGTNGTIRADAGIVMTPQRRVAYAVFANWEPGTDRVVDVMPVMREAGDAIHRFL
>NZ_CP014869.1|WP_082819461.1|3406619_3407732_-|LD-carboxypeptidase
MSESEFVGVDRAAEVGRTTEVEFAGADEPSPYLESAPLAAGDTVRLIAPSGPTDEESLQRAIAQLESWGLKVVPGDNVRARHPRVKYLAGTDAERRADLVDAWCDPDTDAVIALRGGFGAMRLLDGIDFDLMRRHMLRRDGRPKLLTGSSDITALHQAWEHHLGVATLFCPMVGNDPFKNSTVVPDEVASWLFQPWGGRELGFPAEEPAGSLASGVAARPLSRAQTLVPGTAKGRLGGGNLSLIAAGMGSPELIDVRERRERRGPSILMLEDVDEELYRLDNLMVQLVRGGWFTSADAVVLGSWEDCAPVHEVEALMIDYLGGLGIPIVSEMGFGHDPDAPSVPLGVDVTLDAEPGERPRLRVDHAGGQA
>NZ_CP014869.1|WP_062862433.1|3407724_3409380_-|ABC-transporter-ATP-binding-protein
MTDLSFENVSITYRSSSDRGDVVAVEDVSLDLPAGATLGIAGESGSGKSTLIMSALRLLPKSARLDGRVLLGGQDIRELSFGQIRAVRWAQASIVFQGALHSLNPVREVGSQIIEALEHHSKGTWTTPQKRRDRMFELLAEVNLEAAKSSAYPHELSGGQKQRIMIAMALACEPDIIIADEPTTALDVIVQKQILSGLARLVAERGISLLMISHDLAVLSAVCADLAIMRHGRLVEYGPSDKVCLSPQEDYTKQLAGAFPQIGDSESRLNPRTLKPAEVARAEPFTMTDEVVLEAKDLSVSFDTRRGRERAVRGVDLKLRKAEILAVVGQSGSGKTTLARSLLGLQEVEPGSQLSFAGKPLPRKAKELRTFRRQVQMILQDPAGSLNPKRSVYEAVVEGLKVQGIKDREYERVIGALEAAELTPAEDYLESIPQELSGGQRQRVVIAGALALDPQVLIADEPVASLDASVRGEILSLFLALKKNLGMSALIITHDLGLAWNIADTVAVMKRGEIVEYGEVDRVLSDPQHEYTQELLAAVPRLGSQSLVRNE
>NZ_CP014869.1|WP_082018849.1|3409379_3410363_-|ABC-transporter-permease
MSANTPAEAAPGPSSNEPDPRGSGSRTSTSAVDGAKLVRERRLNNAKKNWALFRSDVPALIGAVVLLFFVIIAIAAPLIAPASMLDVTKQLDVDRYAPPSLDHPLGTDDFGREMWVRILWGARVSILVGVAATVMSMVIGTIMGLAAGHFTGLFGGIIMRIVDFFIVLPSLLLAIVLSSVLERGVFTIVVAIGLTSWASTARIVRSQTLSVESRLYIERARILGAGHSHILFRHLLPAVMPLVLANTTLTVGGAIIAESTLSFLGLGDTSKESWGTILKNSMDVSAATSGYWWYVLTPGIAILLVVLAFTMVGRAFEAIINPALRSR
>NZ_CP014869.1|WP_052239887.1|3410362_3411355_-|ABC-transporter-permease
MDEPPAGGSFARYLLRKLGGAATSMVLVILLGFFAFRMLPGDPVLKIAKERPMSPAQIAELRSQYGLDKPVIMQFWDYLVGIVTGDLGESYVYRKSVSSLIGDYLGPTLLLTATAAVIAIVMGLWLGQLSAWRRNTLFDKIASSTSLIFWSVPTFWLGLILLMIFGGTLQWLPTGGMITPGLDPWSPAGIIDVIKHLILPVVSLVAVVYAQFLMIMRASLLEEMSEDYLTTARAKGLTEDEVRRRHAVPNALLPTVTVVFLHIGGLIAGAVTVEAVFSWPGLGKLTFEAIRGPDLPLLQGTFVVFSAIIIVMNLAADIVYRFLDPRVRRA
>NZ_CP014869.1|WP_167556066.1|3411508_3413311_-|ABC-transporter-substrate-binding-protein
MRRGWQRCLAGVAALALAGSMATSPAQAATSEAPASDNVLRIATDGFIDSFNPFTSFYLVPTNTFRYMYENLVANDAKDGSVTEGLATEWNTDSEGKVWTYTIRPDMKWSDGEPLTAKDVAWTYNQMMEKEEMAVANGSLVENFAKVEAPDDGTVKITLKKPQANNPGQEIPVVPEHVWSKVDKPGEFKNDKKSVGSGPFQLESYEANKSITLKANPNFWRGKPKLDEIQYRYYTNSDAQVQAIRSGEVDFITGLSPDQFTALEDADNVELNDGNGRRFNGISINSGIADSKNKEFGTGHEALKDKKVRQAIRAGIDSETLRKQVMQDYAQPATSFIPAVYPDWALKSDNPVISGFDVKKAKKLLDDAGWKEGSDGIREKDGEKLELRFLTDADIPTEQSTAKFLKPWMKDIGIDLKNESTDADTESERTTKGDYDMYFSGWSINPDPDYQLSINTCGQRPDAEGNGGTSQDGWCNKEFDKLYKAQHVELDQAKRQDLVQKALAIHYEETPSVTLWYPNQLEAYRSDRFDNFTKQPTDGGAIANQVGYWGYTSVEPVSEEEATGGGMGAGGWIGIGAAVIVVLGGGGWLLSRRKKSDDRE
>NZ_CP014869.1|WP_082819462.1|3413512_3415000_-|diaminopimelate-decarboxylase
MPSHHHAIPNRRARAIRAIAENSAPPTDAGVSAQPSSASAQPSSAPTQSAAVPALTDDAAVLGLMDLDWVDAAFERLTSAFASDREVLHAVACKAVPLPSLLSRYAEMGAGCEVASPGELELALSAGFAPDRIVFDSPAKTWAELHRAVNLGVSINVDNFDELARLDTILAERNSATATAASARIGVRINPQSGTGLIGALSTATQTSKFGIGLADSGSREALIEAFLARPWLNQIHVHSGSQGISLDKAAVGIRAAVDLAEEINSRASARRITRIDIGGGLSVNFDGEDIAPTFADYRAVLEEQVPGLFDFDIVTEFGRALLAKAGTVLTRVEYAKTTGGRRIAMTQAGVQVATRTAYAPNDWPLRILPFTPDGNPKIAEAADSEIVPTDVAGPACFSGDLLARDRMLPRLDAGDLVAVPETGAYYFSNPFSYNLLPRVPIFGYRTAPDGGTEFFLIRRGQTIAEVLAEAGETELRALSPEHRDFAAEPIAQGS
>NZ_CP014869.1|WP_062862434.1|3415098_3416985_-|helix-turn-helix-domain-containing-protein
MTETASPRLSRLIRDTEGLLLPLTEMADDVVVARVEFGFDLPKVPAAPSATPQTASIAEAAGHVALAGAVVLATGPVHSRAGLDSVLNDYAGAAAIVVPPGTHSHLGDGVELRGSGAPIPVLLERSPHVTWSEILVHLRQLIEGATSAVAWPDIDDLSALAAVIAETTGASITIEDPASRVLTHANLGDELDEIRRETILSGAIPDWRIAELEESGFLDTIRRSTDVVERPAEGTSPARSVIALRSEGELIGTIWAAYPAEVDPEPLREVLRDAARAALPVMLRTLRRSPFEKRIRREALGAILAGSADLGPSATLLSLPFSGSFCVLAFTEVAPDREPVLRFHLRAAFADAVLAHVSSAGAGPAGAGQSRAGSASIGPAGAVSAHAGAGGAAAGERVHLAALVQMSEPTSADQVRDHVIAALRRSLPKTETLCFGVGTPVDRLDAVHRSWTEAAYVVDAVQSSTEDDGGANDDDGEETASRKRSGTYGSQGAHGRIVGATIRDVAARVVGLQVADVLLSADDQSIGGGRVPVGQRGSADQRGPGGGVLAPAQALAAHDELHNGSLLETLRVYFATVGNSAEASRRLHVHTNSLRHRLGRIEEITGLSTAEPADRLWLELSVLAFDRS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

997618 : 1046428

Bacillus_phage(28.57%)

transposase,protease,tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062861109.1\|997618_998695_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_062862769.1\|998741_1002146_-	bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_062861110.1\|1002303_1003845_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_082819282.1\|1003896_1004508_+	uridine kinase	A0A1V0SAA3	Catovirus	2.9e-32	38.6
WP_062861112.1\|1004616_1006281_+	HNH endonuclease	NA	NA	NA	NA
WP_062861113.1\|1006467_1006917_+	hypothetical protein	NA	NA	NA	NA
WP_062861114.1\|1006900_1008616_+	hypothetical protein	NA	NA	NA	NA
WP_062861115.1\|1008654_1010610_-	phenol 2-monooxygenase	NA	NA	NA	NA
WP_082018823.1\|1010655_1012059_-	MHS family MFS transporter	NA	NA	NA	NA
WP_039207935.1\|1012188_1013679_+	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_082819283.1\|1013639_1014398_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_062861116.1\|1014394_1015900_+	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase	NA	NA	NA	NA
WP_062861117.1\|1015907_1017044_+	3,4-dihydroxyphenylacetate 2,3-dioxygenase	NA	NA	NA	NA
WP_062861118.1\|1017055_1017841_+	2-oxo-hepta-3-ene-1,7-dioate hydratase	NA	NA	NA	NA
WP_062861119.1\|1017825_1018614_+	HpcH/HpaI aldolase/citrate lyase family protein	NA	NA	NA	NA
WP_062861120.1\|1018674_1020624_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_156483835.1\|1021237_1022749_+\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_062861121.1\|1022758_1023949_+\|protease	MarP family serine protease	A0A1B1IRH0	uncultured_Mediterranean_phage	1.4e-06	30.9
WP_062245057.1\|1023973_1024915_-	endonuclease/exonuclease/phosphatase family protein	NA	NA	NA	NA
WP_062245054.1\|1024990_1025809_-	winged helix-turn-helix transcriptional regulator	W8CYM9	Bacillus_phage	4.3e-07	42.7
WP_039207917.1\|1026075_1026714_-	uracil phosphoribosyltransferase	NA	NA	NA	NA
WP_062861122.1\|1026787_1027342_+\|tRNA	tRNA adenosine deaminase-associated protein	NA	NA	NA	NA
WP_039207913.1\|1027353_1027785_+	nucleoside deaminase	NA	NA	NA	NA
WP_062861123.1\|1028211_1029672_+	NCS2 family permease	NA	NA	NA	NA
WP_062861124.1\|1029868_1031326_+	2Fe-2S iron-sulfur cluster binding domain-containing protein	A0A0P0IVM8	Acinetobacter_phage	2.8e-62	36.2
WP_062861125.1\|1031325_1033704_+	xanthine dehydrogenase molybdopterin binding subunit	A0A0P0I429	Acinetobacter_phage	1.1e-183	45.6
WP_062861126.1\|1033700_1034486_+	xanthine dehydrogenase accessory protein XdhC	NA	NA	NA	NA
WP_062861127.1\|1034529_1035813_+	guanine deaminase	NA	NA	NA	NA
WP_062861128.1\|1035983_1036808_+	TIM barrel protein	NA	NA	NA	NA
WP_062861129.1\|1036842_1037730_+	2-hydroxy-3-oxopropionate reductase	NA	NA	NA	NA
WP_062861130.1\|1037811_1039605_+	glyoxylate carboligase	M4QSI1	Ostreococcus_lucimarinus_virus	6.0e-38	27.5
WP_062861131.1\|1039710_1041066_+	allantoinase AllB	NA	NA	NA	NA
WP_167556028.1\|1041133_1041598_-\|transposase	transposase	NA	NA	NA	NA
WP_062861133.1\|1042874_1043489_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_062245021.1\|1043898_1044888_+	DUF559 domain-containing protein	NA	NA	NA	NA
WP_039208238.1\|1044986_1045553_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_082018836.1\|1045549_1046428_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	8.8e-59	42.7

DBSCAN-SWA_2

1064703 : 1110196

Gordonia_phage(25.0%)

integrase,transposase,protease,tRNA

attL 1084707:1084734|attR 1086275:1086302

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_156483970.1\|1064703_1065918_+\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	6.2e-63	34.6
WP_062862772.1\|1066113_1066725_-	queuosine precursor transporter	A0A1W7AG82	Streptococcus_virus	1.1e-23	35.0
WP_062861147.1\|1066852_1069435_-	peptidyl-dipeptidase Dcp	NA	NA	NA	NA
WP_062861148.1\|1069529_1070600_+	AI-2E family transporter	NA	NA	NA	NA
WP_062861149.1\|1070617_1070839_-	hypothetical protein	NA	NA	NA	NA
WP_062861150.1\|1070897_1071368_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_062861151.1\|1071364_1071919_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_062861152.1\|1071911_1072586_+	HAD family hydrolase	NA	NA	NA	NA
WP_082819286.1\|1072551_1073190_+	peptidoglycan DD-metalloendopeptidase family protein	NA	NA	NA	NA
WP_062861153.1\|1073358_1074882_+	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_062861154.1\|1074881_1075301_+	DUF779 domain-containing protein	NA	NA	NA	NA
WP_062861155.1\|1075413_1076724_-	alkylhydroperoxidase domain protein	NA	NA	NA	NA
WP_062861156.1\|1076725_1077778_-	putative FMN-dependent luciferase-like monooxygenase	NA	NA	NA	NA
WP_062861157.1\|1077783_1079478_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.4e-15	30.6
WP_062861158.1\|1079474_1080356_-	ABC transporter permease	NA	NA	NA	NA
WP_062861159.1\|1080352_1081432_-	ABC transporter permease	NA	NA	NA	NA
WP_062861160.1\|1081428_1083150_-	TIGR04028 family ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_062861161.1\|1083340_1084042_+	VOC family protein	NA	NA	NA	NA
WP_062861162.1\|1084029_1084698_+	VOC family protein	NA	NA	NA	NA
1084707:1084734	attL	NA	NA	NA	NA
WP_167556022.1\|1084751_1085717_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_062861163.1\|1085776_1086205_-	hypothetical protein	NA	NA	NA	NA
WP_062861164.1\|1086331_1087105_+	DUF3152 domain-containing protein	NA	NA	NA	NA
1086275:1086302	attR	NA	NA	NA	NA
WP_039207840.1\|1087221_1089771_+\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	4.0e-128	39.7
WP_062861165.1\|1089862_1090669_-	membrane protein insertase YidC	NA	NA	NA	NA
WP_039207834.1\|1090793_1091099_-	hypothetical protein	NA	NA	NA	NA
WP_082018820.1\|1091245_1091890_+\|protease	ATP-dependent Clp protease proteolytic subunit	G3M9Z8	Bacillus_virus	1.4e-21	35.2
WP_062244927.1\|1091886_1092468_+\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	1.6e-29	40.0
WP_082819287.1\|1092498_1092858_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_062244923.1\|1093036_1094065_+	iron-siderophore ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_062862774.1\|1094112_1095615_-	L,D-transpeptidase	NA	NA	NA	NA
WP_082819288.1\|1095941_1097366_-	RNA polymerase subunit sigma-24	NA	NA	NA	NA
WP_062861166.1\|1097326_1097758_-	hypothetical protein	NA	NA	NA	NA
WP_052239815.1\|1098387_1099536_+	dimethyl sulfone monooxygenase SfnG	NA	NA	NA	NA
WP_062861167.1\|1101334_1101868_-	type 1 glutamine amidotransferase	NA	NA	NA	NA
WP_062861168.1\|1102106_1102802_-	hypothetical protein	NA	NA	NA	NA
WP_062861169.1\|1103066_1103474_+	hypothetical protein	NA	NA	NA	NA
WP_062861170.1\|1103498_1104698_+	RNA polymerase subunit sigma-24	NA	NA	NA	NA
WP_062861171.1\|1104746_1105679_-	RNA polymerase sigma factor SigJ	NA	NA	NA	NA
WP_062861172.1\|1105675_1106707_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_167556029.1\|1106936_1108007_+	FUSC family protein	NA	NA	NA	NA
WP_062862776.1\|1108118_1108784_+	DNA alkylation repair protein	NA	NA	NA	NA
WP_082819290.1\|1108974_1109154_-\|transposase	transposase	NA	NA	NA	NA
WP_082819291.1\|1109138_1109888_-\|transposase	IS3 family transposase	A0A1B3AZE5	Gordonia_phage	6.6e-47	46.9
WP_040342619.1\|1109884_1110196_-\|transposase	transposase	A0A1B3AZF8	Gordonia_phage	2.1e-15	47.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP014869

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection