CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP012731	Streptococcus suis strain 90-1330 chromosome, complete genome	2 crisprs	cas2,cas1,cas9,DinG,cas3,DEDDh,csa3	1	5	9	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012731_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012731_1

189953-190448

TypeII

Consensus_repeat	Method
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CRISPRCasFinder
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CRT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	PILER-CR

7 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_CP012731_1

>merge|NZ_CP012731|1|189953-190448|CRISPRCasFinder,CRT,PILER-CR
TGATTACGATAATATAAATCTTGAGAGTACAAAAACTACAAATGTTATGGGGATAACTACCAGAAGGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTAACTGAAAATTAGTAGCGTAAGGAAGTGGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACGACAAGGTCGAAAAGAAATACATTGATGTTGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACCCTGCAGATGTTAACCCACTCAATAATCCGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACACATCATTTGTTTATCGGGACCCAACCAATGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACCAGTATTAATTGGGATATTATTTATCTTAGGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACCAACATGGTTTTGATCCCACGTTTGGCCAGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

>NZ_CP012731|1|1|189953-190448|CRISPRCasFinder
TGATTACGATAATATAAATCTTGAGAGTACAAAAAC	TACAAATGTTATGGGGATAACTACCAGAAG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TTAACTGAAAATTAGTAGCGTAAGGAAGTG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	GACAAGGTCGAAAAGAAATACATTGATGTT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CCTGCAGATGTTAACCCACTCAATAATCC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	ACATCATTTGTTTATCGGGACCCAACCAAT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CAGTATTAATTGGGATATTATTTATCTTAG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CAACATGGTTTTGATCCCACGTTTGGCCA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

>NZ_CP012731|1|1|189953-190448|CRT
TGATTACGATAATATAAATCTTGAGAGTACAAAAAC	TACAAATGTTATGGGGATAACTACCAGAAG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TTAACTGAAAATTAGTAGCGTAAGGAAGTG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	GACAAGGTCGAAAAGAAATACATTGATGTT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CCTGCAGATGTTAACCCACTCAATAATCC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	ACATCATTTGTTTATCGGGACCCAACCAAT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CAGTATTAATTGGGATATTATTTATCTTAG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CAACATGGTTTTGATCCCACGTTTGGCCA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

>NZ_CP012731|1|1|190019-190448|PILER-CR
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TTAACTGAAAATTAGTAGCGTAAGGAAGTG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	GACAAGGTCGAAAAGAAATACATTGATGTT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CCTGCAGATGTTAACCCACTCAATAATCC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	ACATCATTTGTTTATCGGGACCCAACCAAT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CAGTATTAATTGGGATATTATTTATCTTAG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CAACATGGTTTTGATCCCACGTTTGGCCA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012731.1\|WP_024395102.1\|187636_188848_-\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
NZ_CP012731.1\|WP_009910394.1\|202212_202995_-\|TPM-domain-containing-protein	unknown	unknown	gnl\|CDD\|224429
NZ_CP012731.1\|WP_002935569.1\|179759_180377_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|240029
NZ_CP012731.1\|WP_002935618.1\|200083_201547_-\|flotillin-family-protein	unknown	unknown	gnl\|CDD\|259798
NZ_CP012731.1\|WP_002935600.1\|191871_192786_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NZ_CP012731.1\|WP_002935629.1\|203066_203645_-\|uracil-DNA-glycosylase-family-protein	unknown	unknown	gnl\|CDD\|381683
NZ_CP012731.1\|WP_009910389.1\|187280_187637_-\|ArsC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|239332
NZ_CP012731.1\|WP_013730441.1\|189176_189851_-\|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl\|CDD\|234816
NZ_CP012731.1\|WP_002935599.1\|191551_191875_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_CP012731.1\|WP_002935572.1\|182556_183135_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_CP012731.1\|WP_002935570.1\|180363_181104_-\|acyl-ACP-thioesterase	unknown	unknown	gnl\|CDD\|366738
NZ_CP012731.1\|WP_002935598.1\|190508_191555_-\|hypothetical-protein	csn2	cd12217_csn2_CAS-II-A	gnl\|CDD\|213410
NZ_CP012731.1\|WP_002935585.1\|186459_187269_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NZ_CP012731.1\|WP_002935571.1\|181334_182462_-\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309
NZ_CP012731.1\|WP_009910392.1\|199686_199995_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012731.1\|WP_002935608.1\|197004_198378_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NZ_CP012731.1\|WP_024409212.1\|192952_196321_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|273840
NZ_CP012731.1\|WP_002935621.1\|201558_202140_-\|LemA-family-protein	unknown	unknown	gnl\|CDD\|377192
NZ_CP012731.1\|WP_002935583.1\|185713_186427_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NZ_CP012731.1\|WP_009910385.1\|183269_185537_-\|glycogen/starch/alpha-glucan-family-phosphorylase	unknown	unknown	gnl\|CDD\|340853

Protein	Function_ID	Function_description	E-value
NZ_CP012731.1\|WP_024395102.1\|187636_188848_-\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
NZ_CP012731.1\|WP_009910394.1\|202212_202995_-\|TPM-domain-containing-protein	gnl\|CDD\|224429	COG1512, COG1512, Beta-propeller domains of methanol dehydrogenase type [General function prediction only].	1.62582e-30
NZ_CP012731.1\|WP_002935569.1\|179759_180377_-\|NUDIX-hydrolase	gnl\|CDD\|240029	cd04672, Nudix_Hydrolase_14, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	3.31442e-61
NZ_CP012731.1\|WP_002935618.1\|200083_201547_-\|flotillin-family-protein	gnl\|CDD\|259798	cd03399, SPFH_flotillin, Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. The flotillin (reggie) like proteins are lipid raft-associated. Individual proteins of this SPFH family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. In addition, microdomains formed from flotillin proteins may be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and interact with a variety of proteins. They may play a role in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and in cancer invasion, and metastasis.	7.80101e-47
NZ_CP012731.1\|WP_002935600.1\|191871_192786_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	2.0775e-122
NZ_CP012731.1\|WP_002935629.1\|203066_203645_-\|uracil-DNA-glycosylase-family-protein	gnl\|CDD\|381683	cd10033, UDG_like, uncharacterized family of the uracil-DNA glycosylase superfamily. Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Uracil may arise from mis-incorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations; thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other. UDG family 1 is the most efficient uracil-DNA glycosylase (UDG, also known as UNG) and shows a specificity for uracil in DNA. UDG family 2 includes thymine DNA glycosylase which removes uracil and thymine from G:U and G:T mismatches, and mismatch-specific uracil DNA glycosylase (MUG) which in Escherichia coli is highly specific to G:U mismatches but also repairs G:T mismatches at high enzyme concentration. UDG family 3 includes Human SMUG1 which can remove uracil and its oxidized pyrimidine derivatives from, single-stranded DNA and double-stranded DNA with a preference for single-stranded DNA. Pedobacter heparinus SMUG2, which is UDG family 3 SMUG1-like, displays catalytic activities towards DNA containing uracil or hypoxanthine/xanthine. UDG family 4 includes Thermotoga maritima TTUDGA, a robust UDG which like family 1, acts on double-stranded and single-stranded uracil-containing DNA. UDG family 5 (UDGb) includes Thermus thermophilus HB8 TTUDGB which acts on double-stranded uracil-containing DNA; it is a hypoxanthine DNA glycosylase acting on double-stranded hypoxanthine-containing DNA except for the C/I base pair, as well as a xanthine DNA glycosylase which acts on both double-stranded and single-stranded xanthine-containing DNA. UDG family 6 hypoxanthine-DNA glycosylase lacks any detectable UDG activity; it excises hypoxanthine. Other UDG families include one represented by Bradyrhizobium diazoefficiens Blr0248 which prefers single-stranded DNA and removes uracil, 5-hydroxymethyl-uracil or xanthine from it.	1.02931e-96
NZ_CP012731.1\|WP_009910389.1\|187280_187637_-\|ArsC-family-transcriptional-regulator	gnl\|CDD\|239332	cd03034, ArsC_ArsC, Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.	1.01834e-20
NZ_CP012731.1\|WP_013730441.1\|189176_189851_-\|ribose-5-phosphate-isomerase-RpiA	gnl\|CDD\|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	3.34018e-113
NZ_CP012731.1\|WP_002935599.1\|191551_191875_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	9.7745e-25
NZ_CP012731.1\|WP_002935572.1\|182556_183135_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	9.00811e-06
NZ_CP012731.1\|WP_002935570.1\|180363_181104_-\|acyl-ACP-thioesterase	gnl\|CDD\|366738	pfam01643, Acyl-ACP_TE, Acyl-ACP thioesterase. This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid.	7.63063e-88
NZ_CP012731.1\|WP_002935598.1\|190508_191555_-\|hypothetical-protein	gnl\|CDD\|213410	cd12217, Stu0660_Csn2, Stu0660-like CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. This family of Csn2 proteins includes Stu0660, the proteins are larger than other (canonical) Csn2 proteins as they have an additional alpha-helical C-terminal domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	2.6417e-137
NZ_CP012731.1\|WP_002935585.1\|186459_187269_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	6.03224e-162
NZ_CP012731.1\|WP_002935571.1\|181334_182462_-\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0
NZ_CP012731.1\|WP_002935608.1\|197004_198378_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NZ_CP012731.1\|WP_024409212.1\|192952_196321_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	3.78961e-178
NZ_CP012731.1\|WP_002935621.1\|201558_202140_-\|LemA-family-protein	gnl\|CDD\|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	8.85941e-67
NZ_CP012731.1\|WP_002935583.1\|185713_186427_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	4.90632e-151
NZ_CP012731.1\|WP_009910385.1\|183269_185537_-\|glycogen/starch/alpha-glucan-family-phosphorylase	gnl\|CDD\|340853	cd04300, GT35_Glycogen_Phosphorylase, glycogen phosphorylase and similar proteins. This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism. The allosteric control mechanisms of yeast and mammalian members of this family are different from that of bacterial members. The members of this family belong to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	0

>NZ_CP012731.1|WP_013730441.1|189176_189851_-|ribose-5-phosphate-isomerase-RpiA
MTNLKEQVGIKAAEFVTDGMIVGLGTGSTAYYFVQEIGRRVAEEGLQITGVTTSHATAEHAASLGIPLKNIDEVEYVDLTVDGADEVDGDFNGIKGGGAALLMEKVVAVNSKDCIWIVDESKVVQTLGAFKLPVEVVQYGAENLFRLFEKKGYRPSFRMRNGEKHITDMQNFIIDLDLRRIEDTYALAEELDRTVGVVEHGLFIGLISKVIVGTLEGPNIIEKK
>NZ_CP012731.1|WP_024395102.1|187636_188848_-|phosphopentomutase
MPKFKRVHLVVMDSVGIGAAPDSDKFFNAGVADTESDTLGHISEKAGLEVPNMTKIGLGNIPRDTALATVPAESHPTGYVTKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWDGFPEEILTKIEEFSGRKIIREANKPYSGTAVIDDFGPRQMETGELIVYTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIARPYVGEPGNFSRTANRHDYAVSPFKATVLNKLADAGVPTYSVGKISDIFNGSGITNDMGHTKSNMHGVDVLIDTLKLSDFEEGFSFTNLVDFDAVYGHRRNIEGYRDCLQEFDARIPEIIDNMREDDLLLITADHGNDPSYAGTDHTREYVPLLAYSKAFKGSGVLPVGHFADISATVAENFGVDTAMIGESFLSQLV
>NZ_CP012731.1|WP_009910389.1|187280_187637_-|ArsC-family-transcriptional-regulator
MEKLTVYYNPNCSKCKKLRILLSSQDMEVKWVNYLETPLRGAELTALLEKMGSQPSAVTRLKEEERLALSEEEIFERLVEEPATLNRPIIEREQTAFLCRPLEIIKEKMPEYDWSDYL
>NZ_CP012731.1|WP_002935585.1|186459_187269_-|purine-nucleoside-phosphorylase
MSLLAKINETKTFLEEKGLVKPEFGLILGSGLGELAQEVENAIVIDYADIPNWGKSTVVGHAGKLVYGDLAGRKVLALQGRFHFYEGNPMEVVTFPVRVMKALGCEGVIVTNAAGGIGYGPGTLMAITDHINMTGQNPLIGENLEEFGPRFPDMSNAYTKEYREKAHAVAEKLGIKLDDGVYLGVTGPTYETPAEILAFKTMGAHAVGMSTVPEVIVAAHSGMKVLGISAITNFAAGFQSELNHEEVVEVTEQIKGNFKGLVKAILAEL
>NZ_CP012731.1|WP_002935583.1|185713_186427_-|purine-nucleoside-phosphorylase
MSIHISAKPGEIADKILLPGDPLRAKFIAENFLEDAVCFNEVRNMFGYTGTYKGHRVSVMGTGMGMPSISIYAHELINEYGVKKLIRVGTAGSLNEDVHVRELVLAQAAATNSRMINIDWPEYDLPQIADFDLLDKAYHIAKELNMTTHVGNVLSSDSFYSPKLFSRNLELGQLGVKAVEMEAAALYYLGAKFGVQTLAIMTISDSLVNPEENTTAEERQNTFTDMMKVGLETLIAE
>NZ_CP012731.1|WP_009910385.1|183269_185537_-|glycogen/starch/alpha-glucan-family-phosphorylase
MINLQNFVQSMYAKRIEDCTDQELYYALLAFTKQQSEAKYTNDQKKKVYYISAEFLIGKLLSNNLINLGLYDEVKSQLVAAGKDLIAIEDMELEPSLGNGGLGRLAACFLDSIASLGLNGDGVGLNYHFGLFRQLFEYHQQSAVPNEWITPRSWLTESPISYQVPFANFTLTSKLYDIDVPGYKMERKNRLRLFDLGSVDDNIIYDGIEFDKEDIFRNLTLFLYPDDSTDEGKVLRIFQQYFMVSNAAQLLIDEAVAKGSNLHDLPDYAVVQINDTHPSLVIPELIRLLELRGISFDEAVEIVKKMTAYTNHTILSEALEKWPLDFLNYVVPHLVPFIVELDRRAKEVKDDPAVNIIDEYGRVHMAHMDIHYGYSINGVAALHTEILKTSELKAFYELYPEKFNNKTNGITFRRWLMHANPSLASYLDGLLGHGYHHDASELEKLLDYKNDKELKSWLEKTKQHNKRKLQRHIAKTQGVHVNPESIFDVQIKRMHEYKRQQMNVLYVIHKYLDIKAGNIPTRPLTVFFGGKAAPAYTTAQDIIHLILVLSQVIKNDSEVAPHLQLVMIENYNVTEASFIIPAADISEQISLASKEASGTGNMKFMLNGALTIGTDDGANVEIHELVGDENIYIFGQDSQTVIEHYANRTYHPYSFYEREVIRPLIDFITSDTIRHAGGIDERLWRLQDNLKHNDHFMTLLDLEDYIVTKERMLADYEDRDSWLEKVIVNIAKAGFFSSDRTIQQYNEDIWHLEAK
>NZ_CP012731.1|WP_002935572.1|182556_183135_+|VanZ-family-protein
MKKEIIYDCINLILSFLLCRWLFMTFLFYQFSNIFMTIDFWPTLAAILLMTGFCFTLFRLVYKPHISRLTLWFFYACYGLLLVYLLFFKSMGVRGVNWNLLSTFSQDLFLNPTILVFNLLLFLPLGLLFSFSWKKLSLFVGAILLVEACQFFFSLGFFDLGDILLNTSGFALGNFLGQSAIAQSFKNRIQKK
>NZ_CP012731.1|WP_002935571.1|181334_182462_-|oxygen-independent-coproporphyrinogen-III-oxidase
MKKRPTSAYIHIPFCTQICYYCDFSKVFIKNQPVDEYLAALMEEVKFYDLPALRTLYIGGGTPSALSADQLDYLLTNLEDLLDLSQLEEFTIEANPGDLTADKIAVLKKSKCNRVSLGVQTFDDRMLKKIGRSHNQAQIYETIATLKEAGFYNISIDLIYALPGQTMEQVVDNVAKALELDIPHMSLYSLILENHTVFMNRQRRGNLHLPNEDVESDMFDYILQELEKNGFEHYEISNFTKPGFESRHNLMYWDNSEYYGLGAGASGYIDGMRYRNRGPIQHYLKSIREKGHSRLHEEFLSQTEQMEEEMFLGLRKKTGVSIERFEEKFGISFEDRYGQVVRDLKNEGLLQEEDRWLRMTKKGLFLGDTVAERFI
>NZ_CP012731.1|WP_002935570.1|180363_181104_-|acyl-ACP-thioesterase
MGLTYQEEFTIPFDMVDVKQEIKLPDFISYCLGVSGRQSEELGRSDLYVFQEFGLIWVVTDYELTIQRLPKYNETITIKTEAVAYNKFFCHRMFYIYDAAGNLLLDILCYFVLIDFETRKVAPVPEDLIAPYQSEQVKKLPRAPKYQLLENPSVQEFPVRYFDLDMNGHVNNGKYLEWMYEALGYDFLLCHVPKKIQLKYLKEVEATSLVSSRMVAEAGGSQHEIVVDGHIHAQAVIEWRERHVAG
>NZ_CP012731.1|WP_002935569.1|179759_180377_-|NUDIX-hydrolase
MSQDKWLEWAVRLQALAQTGLAYGKDVYDMERFEEIRQIAAEMLVEPSGQPLEVVKDLFCNETGYQTPKLDTRAAIFQEDKILLVQENDGLWSLPGGWCDVDQSVKDNVVKEVKEEAGLDVEAQRVVAILDKHKNNPAKSAHRVTKVFILCRLLGGEFQPNSETVASGFFSLDDLPPLYLGKNTAEQLALCLEASRSEHWETRFD
>NZ_CP012731.1|WP_002935598.1|190508_191555_-|hypothetical-protein
MKWLITHHVLNNIPIHVGQFTQIVGQNYELKYYIWQILIWYFGGKKYSEEDLILFNQEEPVISQDSEAIKRNAFKIISIAEVGDILEQISYKKGTIGFSYLSLKMQNIEIIEELEILNYHLHKIAQKVNSSISLINDEIEYEVGTTDLLPEQILTKQLTPHFKKSRDEIAIEFISNEKKLCFLLQMLNAIMQEQTKPILLVLKNLDDYLTYDSFVRIAQYLEELSNKYPYFNTILFPSQEGYLYLTEATLETVNIVSDRIEHYPAFTFLYTRYQQSYPSTSPLGEKEFLNSLRKISSYLFSSDINRVVSLADIDLVTLKIVNSLYQYDIKMVYMYKGISKLEENYLSS
>NZ_CP012731.1|WP_002935599.1|191551_191875_-|CRISPR-associated-endonuclease-Cas2
MRYDAMRLLCFFDLPMETTQEKRQYRLFRKELIANGFEMLQFSVYYRTCPNRSFATKFYKKLQQSHLPAGNVRLLAVTEKQFSEMVLIVGGKTRQEEAISDRKLVII
>NZ_CP012731.1|WP_002935600.1|191871_192786_-|type-II-CRISPR-associated-endonuclease-Cas1
MTWRIVHIHQSEKMRLKLDNLVIKKQGDEFTIPLSDISIIVAEGGDTVVTLRLLSALSKYNIALIVCDNHHLPTGIYHSQNGHFRAYKKLQAQLSWAPLQKDKLWQIIIYFKITNQQDVLAMQEKSLSTIQLLSDYREHIELGDRTNREGHAAKVYFNELFGKQFVRLTQQETDAVNAGLNYGYTIFRAQMARIIAGYGLNALIGIFHKNEYNQFNLADDLMEPFRQIVDVWVYMNLREADFLTYQHRLELTNLLNAKIRYGKENCSVTVAMDKFVKGFIRCIEDKDTNQFFCPVVSSLEMEKL
>NZ_CP012731.1|WP_024409212.1|192952_196321_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MSNGKILGLDIGIASVGVGVIDAQTGEIIHASSRIFPSANAANNAERRTFRGSRRLIRRKKHRIKRLDDLFNDFHINLDGEMSTDNPYVLRVKGLSQKLTVEELYISIKNIMKRRGISYLDDAESDNEAGRSDYAKAIERNRQLLTSKTPGEIQLERLEKYGQLRGNFTIIDEEGQSQQIINVFSTSDYVKEVEKILDCQKMYHKFISDEFCDKLIELLREKRKYYVGPGNEKSRTDYGIYRTDGTTLENLFGILIGKCTFYPDQYRSSRASYTAQEFNFLNDLNNLTVPTETKKLSQEQKEFLVNYAKETSVLGAGKILQQIAKLADCKVEDIRGYRLDNKDKPELHTFETYRAMKGLVPLVDIGVLSREQLDILADILTLNTDFEGIREALKKQLPNVFDEKQVKGLASFRKSKSQLFAKGWHNLSQKIMLEVIPELYATSDEQMTILTRLGKFEKSSVAEYPSSINVDEITDEIYNPVVAKSIRQTIKIINASIKKWGEFDQIVIEMPRDRNEDEEKKRIADGQKANAKEKADSILRAAELYCAGKVLPDYVYNGHNQLATKIRLWYQQGERCIYTGQPISIHDLIHNQNQYEIDHILPLSLTFDDSLSNKVLVLATANQEKAQRTPYNYLKSATSAWSYREFKDYVTKRKGIGKKKCEYLTFEEDINGFEVRSKFIQRNLVDTRYASKVILNALQDYFKISGIQTKVSVVRGQFTSQLRHKWGIEKTRETYHHHAVDALIIAASSQLRLWKKQESPLVVDYQEGRQVDLETGEILELTDEQYKELVYQPPYQGFVNTISSSAFDNEILFSYQVDSKVNRKISDATIYATRNAQLGKDKTEGIYVLGKIKDIYTQAGYEAFLKRYTKDKTSFLMYHKDLDTWEKVIEIILRDYREYDEKGKEIGNPFERYRRENGYVKKYSRKGNGTAIKSLKYYDNKLGNHIDITPENSRNAVVLQSLKPWRTDVYFNKETGKYEFLGIKYSDLSFEKGTGEYGISQEKYDSIKIAEGVAKKSIFKFTLYKQDLLFIKDIENNFGKLLRFTSKNDTSKHYVELKPYDKNKFGTEEPLLPVLGNVAKSGRCIKGLNKSNISIYKVRTDILGYRHFIKQEGEHPQLKFKK
>NZ_CP012731.1|WP_002935608.1|197004_198378_+|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MITKEFDTITAISTPLGEGAIGIVRLSGTDAFAIASKVFKGKDLATVPSHSLNYGHIIDPATGQVLDEVILGVMRSPKTFTREDVIEINTHGGIAVTNEILQLLIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDVIRAKTDKAMHNAVRQLDGSLSQLINDTRQEILNTLAQVEVNIDYPEYDDVEEATTELVREKTLQFQALLENLLRTARRGKILREGIATAIIGRPNVGKSSLLNNLLREEKAIVTDIAGTTRDVIEEYVNIKGVPLKLIDTAGIRETDDIVEKIGVERSKKALEEADLILLVLNASEPLTEQDRNLLAISDLANRIVLLNKTDLEEQIEADQLPEDVIRISVLKNQNIDQIEEKINQLFFENAGLVEQDATYLSNSRHISLIEQAVQSLQAVNDGLEMGMPVDLLQVDLTRCWQILGEITGDAAPDELITQLFSQFCLGK
>NZ_CP012731.1|WP_009910392.1|199686_199995_-|hypothetical-protein
MKMFRNSKKSKLFIQKINELLSDSELKLSKALKFQLLEAMELCEKGSKISYLSYKIYPWVLEELALNRIQSDKLKMFKRYLEQERWKYYFGSALGMAFTSIR
>NZ_CP012731.1|WP_002935618.1|200083_201547_-|flotillin-family-protein
MDFGFDILAIMIPIIVVVLFVLLFVFGYVSAKPNEAIVITGLGKPRTLIGRSGFMIPFIEKRSYISIEQFSTDVQTTDFVPTLDFINVKADAVVKVKVGISDELLNAAAQNFLNWKTADISASIQDVLEGNLREIIGQMELRDMVNNRQAFAEKVQSNAAPDLAKMGLEIIAFTVQSFTDDNDVIKNLGIDNIVTIQKDAANARAKAEREQAEVRAREDKAANDARVAADLEIAKKQNELAIEQANLKRQSDVQLAQANAAYGIEEQAQRKEIERATAEANIVKQQKEAEVKAEEVKVREQELSATIRKQAEAEKYARQQAAEADLIERQRKAEAELYETQREAEAQKARAEAAKYAAEQEAAGIEAKGRAEAEAIRLKLEAEAEGLSKKADAMAKFNDAAVTEMVVNVLPEIAKNIAAPLGNVDKITMYGEGNASKMVGDLMTTMDKTTEGLGLNVRDLISATLTGRAMSTGLLTAQETKEAEGDK
>NZ_CP012731.1|WP_002935621.1|201558_202140_-|LemA-family-protein
MKKKWLAILLPILALLFLGMGAVGQYNGLVDSYAEVENAQANVDTQLQRRYDLIPNVVAAVKGAMEHEEEIFTAIAEARAKIGSSQVGTSDYNQAQSQLDSAVSRLLVVAENYPQLTANQQVSALITELEGTENRILVARKDYNSVATTYNKKIKRFPTSIYANLFGYEKVELFQATNDAATTVPSVDLSDKE
>NZ_CP012731.1|WP_009910394.1|202212_202995_-|TPM-domain-containing-protein
MRKWKKIIIGCFAILTVCLLFAPTLARANQIPDRPTGTTVVDETQLLSSETIAEIDQLNRSWASTEQALQVGVYVTESLSSDIESLANETFRHWQVGFAGTDNGVLLVVAIADRAFRIETSDNAATVITDVEAKDILENAREFFRQEDYSGGISYIVNSIGDRFYGTSIGKNQLAAIEEGTSEKDDGFWLFLIVILIAILFGIIDKSSRGGGGPGNLLWMLVDDHHHYHNHHSSNSSSSSFGGGSWSGGGGGGGGASSGW
>NZ_CP012731.1|WP_002935629.1|203066_203645_-|uracil-DNA-glycosylase-family-protein
MELADIRQAIIEDVANRDFTNKGIAPLFQAPSTAKILIIGQAPGLKTQEKGRLFDDASGNNLRQWLGVDRQTFYESGHFAILPMDFYYPGKGKSGDLPPRKDFAPKWHPLIMKQLPQIELTILVGNYAQTYYLEKSQRNLTERVKHADDYLPKYFPLPHPSPRNNIWQAKHPWFVEQTLPILKNNINILLGK

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Crispr_ID: NZ_CP012731_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012731_2

2118339-2118422

Orphan

Consensus_repeat	Method
GGAGGTTGGAAATTGAGCGAACGAAGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012731_2

>merge|NZ_CP012731|2|2118339-2118422|CRISPRCasFinder
GGAGGTTGGAAATTGAGCGAACGAAGTTCATTTCTACAAAGGTTTGGGGAAACTTGGGAGGTTGGAAATAGAGCGAACGAAGTT

>NZ_CP012731|2|2|2118339-2118422|CRISPRCasFinder
GGAGGTTGGAAATTGAGCGAACGAAGTT	CATTTCTACAAAGGTTTGGGGAAACTTG
GGAGGTTGGAAATAGAGCGAACGAAGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012731.1\|WP_032497578.1\|2124200_2125028_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|235317
NZ_CP012731.1\|WP_002935243.1\|2125760_2126327_+\|CYTH-domain-containing-protein	unknown	unknown	gnl\|CDD\|143627
NZ_CP012731.1\|WP_002935242.1\|2125002_2125674_-\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232
NZ_CP012731.1\|WP_002935238.1\|2120577_2122314_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP012731.1\|WP_002935231.1\|2113193_2114225_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP012731.1\|WP_002935234.1\|2115614_2116415_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225484
NZ_CP012731.1\|WP_029694144.1\|2118472_2118865_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|224961
NZ_CP012731.1\|WP_002935233.1\|2115012_2115483_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012731.1\|WP_002935232.1\|2114450_2114993_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012731.1\|WP_009909911.1\|2108910_2109843_-\|tagatose-6-phosphate-kinase	unknown	unknown	gnl\|CDD\|237405
NZ_CP012731.1\|WP_002935226.1\|2111023_2111791_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP012731.1\|WP_013730386.1\|2117077_2118238_-\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NZ_CP012731.1\|WP_002935225.1\|2110394_2110817_-\|galactose-6-phosphate-isomerase-subunit-LacA	unknown	unknown	gnl\|CDD\|181505
NZ_CP012731.1\|WP_002935240.1\|2123307_2124201_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP012731.1\|WP_002935224.1\|2109852_2110368_-\|galactose-6-phosphate-isomerase-subunit-LacB	unknown	unknown	gnl\|CDD\|181506
NZ_CP012731.1\|WP_062897151.1\|2118848_2120591_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP012731.1\|WP_002935239.1\|2122315_2123290_-\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|236609
NZ_CP012731.1\|WP_009909915.1\|2112069_2112825_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012731.1\|WP_002935247.1\|2127459_2128575_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NZ_CP012731.1\|WP_009909926.1\|2126471_2127449_+\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|235039

Protein	Function_ID	Function_description	E-value
NZ_CP012731.1\|WP_032497578.1\|2124200_2125028_-\|NAD-kinase	gnl\|CDD\|235317	PRK04885, ppnK, inorganic polyphosphate/ATP-NAD kinase; Provisional.	1.85355e-172
NZ_CP012731.1\|WP_002935243.1\|2125760_2126327_+\|CYTH-domain-containing-protein	gnl\|CDD\|143627	cd07762, CYTH-like_Pase_1, Uncharacterized subgroup 1 of the CYTH-like superfamily. Enzymes belonging to the CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) superfamily hydrolyze triphosphate-containing substrates, require metal cations as cofactors, and have a unique active site located at the center of an eight-stranded antiparallel beta barrel tunnel (the triphosphate tunnel). The name CYTH originated from the gene designation for bacterial class IV adenylyl cyclases (CyaB) and from thiamine triphosphatase. Class IV adenylate cyclases catalyze the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. Thiamine triphosphatase is a soluble cytosolic enzyme which converts thiamine triphosphate to thiamine diphosphate. This domain superfamily also contains RNA triphosphatases, membrane-associated polyphosphate polymerases, tripolyphosphatases, nucleoside triphosphatases, nucleoside tetraphosphatases and other proteins with unknown functions. Proteins of this subgroup are of bacterial origin and have not been characterized.	3.30094e-69
NZ_CP012731.1\|WP_002935242.1\|2125002_2125674_-\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	5.5421e-94
NZ_CP012731.1\|WP_002935238.1\|2120577_2122314_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	5.29037e-130
NZ_CP012731.1\|WP_002935225.1\|2110394_2110817_-\|galactose-6-phosphate-isomerase-subunit-LacA	gnl\|CDD\|181505	PRK08621, PRK08621, galactose-6-phosphate isomerase subunit LacA; Reviewed.	6.97048e-84
NZ_CP012731.1\|WP_002935234.1\|2115614_2116415_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225484	COG2932, COG2932, Predicted transcriptional regulator [Transcription].	2.87242e-15
NZ_CP012731.1\|WP_029694144.1\|2118472_2118865_-\|PaaI-family-thioesterase	gnl\|CDD\|224961	COG2050, PaaI, HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism].	5.94332e-25
NZ_CP012731.1\|WP_002935247.1\|2127459_2128575_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	3.30339e-174
NZ_CP012731.1\|WP_009909911.1\|2108910_2109843_-\|tagatose-6-phosphate-kinase	gnl\|CDD\|237405	PRK13508, PRK13508, tagatose-6-phosphate kinase; Provisional.	1.63555e-171
NZ_CP012731.1\|WP_002935226.1\|2111023_2111791_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.73173e-82
NZ_CP012731.1\|WP_013730386.1\|2117077_2118238_-\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	1.46415e-147
NZ_CP012731.1\|WP_002935231.1\|2113193_2114225_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.90416e-22
NZ_CP012731.1\|WP_002935240.1\|2123307_2124201_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	7.61445e-90
NZ_CP012731.1\|WP_002935224.1\|2109852_2110368_-\|galactose-6-phosphate-isomerase-subunit-LacB	gnl\|CDD\|181506	PRK08622, PRK08622, galactose-6-phosphate isomerase subunit LacB; Reviewed.	8.87204e-126
NZ_CP012731.1\|WP_062897151.1\|2118848_2120591_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.5188e-169
NZ_CP012731.1\|WP_002935239.1\|2122315_2123290_-\|phosphate-acetyltransferase	gnl\|CDD\|236609	PRK09653, eutD, phosphotransacetylase.	0
NZ_CP012731.1\|WP_009909926.1\|2126471_2127449_+\|ribose-phosphate-diphosphokinase	gnl\|CDD\|235039	PRK02458, PRK02458, ribose-phosphate pyrophosphokinase; Provisional.	0

>NZ_CP012731.1|WP_013730386.1|2117077_2118238_-|A/G-specific-adenine-glycosylase
MLDLKEYGIEMWPEEKIQAFRKALLDWYDANKRDLPWRRTKDPYAIWVSEIMLQQTRVDTVIPYYERFLHYLPTISDLAQAPEEVILKLWEGLGYYSRVRNMQKAAQQMVEDFDGQFPTTHAAISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLSRLFEVDYDIGLPANRKIFQAMMELLIDPERPGDFNQALMDLGSDIESPVNPRPQDSPVKAFSAAYLNGTMDKYPIKAPKKKPIPVAYQGFLIRNKDNQFLLEKNNEAGLLSGFWSFPLLEKGAIVEKQVSLFEVAEEVVQPDIRQSFTELYGLTVDWQEQEFGIVQHIFSHRKWQIEMVEGVAETLNLPESKELKWVSVEDFPTYPFAKPQQKMWENFIKEKEKQKS
>NZ_CP012731.1|WP_002935234.1|2115614_2116415_+|helix-turn-helix-transcriptional-regulator
MILGDILKEYRSKNKLSMDKFAELSGLTKGYISMLEKNQHPKTKKALLPTMDTLEKVAKGMAISVGELIEQLDSNQDIALTITPSQFKLFQQPIHPEVQTLDNELKGDFHAQWLTFGQEQLAAMQTTSITPSASILHLDDYRERIDLPVPGKVSAGTGYWQDTDMNNLVSFYNDEIPDNQSYDTIAQVVGDSMAPHIEDGDYLFIRLTPHIPLNTIGIFSVNGENFVKKFKGDYLQSLNSDYDDIYFSPEDDIRPIGQVVDIYSPD
>NZ_CP012731.1|WP_002935233.1|2115012_2115483_-|hypothetical-protein
MKRMTEISWNDIYKEWETYANHFGLTTPINTENLRDQKSKDFGKGSLITLDLLADYDTDSEKTAAIWVASFCRDLIQDYAYLLNGRAYLTVNQIYFQALKQFQSGAVIWSKPLTRLQPKLFVSYRLLENLDLSHYSCVVELAMLQASMVRTQILEK
>NZ_CP012731.1|WP_002935232.1|2114450_2114993_-|hypothetical-protein
MFNLLNKKAEVSKVAEYWNDTLIERGILSADELLEGKCWRCKSSHGVAVCQIVSSKWSKDASLANQMVLCLSCQHEKPNVADTEIVWQWLEVENDERYWTLQGMAEYEKMYKKSVLQELWDMGIRDGEEVETLVNKVTSLSRKNDIVLNRATLAGLFRCEIEQMRRKAFLNWTGIFKLVS
>NZ_CP012731.1|WP_002935231.1|2113193_2114225_+|tyrosine-type-recombinase/integrase
MATITKRGNSYRATVSLYKKGEYKRETKTFSNRKDAELWTLEMELEKGRGKNIAERSTLFPDFYRNWVHTVKKTDVREATFINYKRTLVIVDDLFDGIQLKHLDDLVMQKKIDQYAETHSKKTVKELVLKIRGSLKYAYARGLISNDFGHLLKSKGQEQPKSITEFKKLRQYCLSHTENEFNVLVALALETVARRGELLGIKKEDIFEYGIKILRSISPTNDDTRLKTKYSKRDISINEDVYQAVTKLAQTKEGYIFDWNGFKQASQLQKLLKQLGLTKTTFHGLRDTHASFLFSKDISLDYISRHLGHNSILTTQQYYLELMPEKKHQQDADALSLLNDLSL
>NZ_CP012731.1|WP_009909915.1|2112069_2112825_+|hypothetical-protein
MALGNVEKDTEGWIELINQYLQYCIEIGLSPYTQATYKVALTKVLGVSSTNFIATQPRTRANRMNNRVLHKDYRLSNKNNDYWHKVVTSTGLRKSELIHVTGDALQRGRDGRWYLNLAGHKHHTKGRRDRWSPIMATSQEEEEWLVAIFQRAGEKKVFHVPKDLILDDFDGKKVPTALKSHKYPTEYAERVYRSVAREISKIRNRKEVIHLRKELVGISLNRKACKIVIKTLGHNRPEEFPRSYAYILLKR
>NZ_CP012731.1|WP_002935226.1|2111023_2111791_-|DeoR/GlpR-transcriptional-regulator
MNKRERLEEITRLVNKKGTVRISEIVELLNVTDMTVRRDFIELEEQGVLTKIHGGARSNKAFQYREYSHSEKHIQNKEAKQEIAERAAQLIEDGDTVFLGPGTTVAFLAEAIKNSRLTVITNCMPVFTILSQKKTEEFQVFLLGGEYRQVTESFVGEITNTSLEKMRFSKIFFSGNGLKGTDVMTSTLAEAYTQNIAIKHSLEKYLLLDASKIGKDDFTSFCDLHDVTALVTDMNAKDENYQLLSKHIEIITTKL
>NZ_CP012731.1|WP_002935225.1|2110394_2110817_-|galactose-6-phosphate-isomerase-subunit-LacA
MTIIIGADPAGSKLKDVIKDYLLEKSYDFKDVSDGSDFVDTTLAVVAEVNQQEGNLGIVIDAYGVGPFMTATKVKGMIAAEVSDERSAYMTRGHNNSRIITIGSEIVGEGIAKNIVKGFVEGEYDGGRHQIRVDMLNKMC
>NZ_CP012731.1|WP_002935224.1|2109852_2110368_-|galactose-6-phosphate-isomerase-subunit-LacB
MKIAIGCDHIVTYEKIAVVDYLKNQGYEVLDFGTYDNVRTHYPIFGKKVGEAVASGQADLGICICGTGVGINNAVNKVPGVRSALVRDMTSALYAKEELNANVIGFGGKITGELLMCDIIEAFIKAEYKPTEANKRLIEKIAAVETLNQEQANPEFFTEFLEKWDRGEYQD
>NZ_CP012731.1|WP_009909911.1|2108910_2109843_-|tagatose-6-phosphate-kinase
MILTITLNPSVDIAYQLDTFHLDTVNRVEKVQKTAGGKGLNVTRVLKQIGEDVVATGFIGGEIGSYVKKQLTRNDIKNSFVEIGSETRNCIAVLHDGKQTEILEQGPTIQEHEALNFIEHLEIILNNVDVVVISGSLPKGLASNYYVEIVELCKKCGVAVVLDCSGEALKNVLESQQKPTVIKPNTEELSQLIGKEVTDDIQELKSVLSGQLFQGIDWIVVSLGAQGAFAKYKDKFYRVRIPKIKVVNPVGSGDSTVAGIAAGLVHALPEAELLKNANVLGMLNAQEEQTGYVNLVHSESLYSQIEVEEV
>NZ_CP012731.1|WP_029694144.1|2118472_2118865_-|PaaI-family-thioesterase
MKVLDKLNLQPITVLDDYQATMLNEKEVLLTTKVTEKSLNPYGMAHGGFLFTLADSVAGLTTVAGGSYSVTLQSNIHYMKAAKLGDTLSVTGSCTHDGSRTKVVEVKIKNQDKQLLASASFTMFVTGKVE
>NZ_CP012731.1|WP_062897151.1|2118848_2120591_-|ABC-transporter-ATP-binding-protein
MKQSSFKELVRLVLGQPFQMYLMLVGTLVQVLLTVYLPILIGQAVDAVLIADGQVLLGIIGKMVMVILLNTLVQWYLPLVTNRLVYGMVADLREQVYVKLHQMPLSYLDRHSVGDLVARFSSDSEQLTNGLLMVFNQFFIGILTIFLTIFTMARLDLTMMLLVVALTPVSLLVARYIAKKSYGYYRKQTQARGKQSQLLEESISQLTLVQSFNAQEQFTQGFQVVNDQYATYSQQAIFASSTVNPSTRFINAIIYALLAGLGALRIMAGQFTVGSLTTFLNYASQYSKPFNDISSVLSELQSALACADRLFAILALDSIDDQAERKIDSEELKGAISFDNVSFSYSPERSLIEHLDIDVEAGQKVAIVGPTGAGKSTMINLLMRFYDVTAGQIVLDGVPIRQYSHEDLRRQIGMVLQETWIKSGTIHDNIAYGYPNATRELVIEAAKAANADFFIRQLPQGYDTVLADGGEGLSQGQRQLLSIARVFVKIPKILILDEATSSIDTRTEILVQEAFAKLMEGRTSFIIAHRLSTIQSADLILVMVDGKIVEQGNHEALMAEQGVYYQMQTSQQTEEDESVR
>NZ_CP012731.1|WP_002935238.1|2120577_2122314_-|ABC-transporter-ATP-binding-protein
MKFLSRYFKDYIKESILGPVFKLLEACFELLVPLIIAYIVDTIIPNGSQGNLVAMLFLLVGLACIGIIVSLIAQYYSAKAAVGVTKELTNDLYQKVLSLPKSSRDILSSSSLLTRLTSDTLQIQTGINTFLRLFLRAPIVVFGSLIMAFYISPSLSAYFLEMIILLIFIVTVISVMTSRIYQSMRKELDGLVGQVRETVTGWRVIRAFGQREREIKAFQGINQIYKKQQLQAGFWSSLLSPLTFLVVNGTLLILIWQGNIAISHNLLEQGMLVALINYLLQILVELVKMIMVVSTLNQTYISAQRIQEVFDQTSEDVESSLPKVVSEDKEIIFSVRHISFSYPKSAEESLSDIAFDLRKGQFMGIIGGTGSGKSTLVDLLQALYSVPTNQLSLFIDGKSPKNLKEWRQQIAIVPQQAQLFAGTVRSNLSLGLESVLDSELWAALEIAQAKSFIEDKGGLDSPVEAFGKNFSGGQRQRLTIARAILQKAPILVLDDATSALDYLTESRLLAAIRRAFPAQTLIMVSQRTNSLRTADQILVFDQGRQVGLGRHEDLLRSSAIYQEIDQSQHREEDSHETI
>NZ_CP012731.1|WP_002935239.1|2122315_2123290_-|phosphate-acetyltransferase
MKIFEQLATKLEGKKVRIVLPEGEEPRILQATKRLVNESDVVPVLLGNPDRIKIYLDIEGITEGFEIIDPAHYDRYDEMVAALVERRKGKVSEEQAHELLKDVNYFGVMLVYMGVVEGMVSGAIHSTASTVRPALQIIKTEPGVSKTSGAFLMVKGEERYIFGDCAINIDPDAQTLAEIAINSARTAKMFGIDPKVAMLSYSTKGSGAGPKVDKVVEATKIAQKLRPELDLDGELQFDAAFVPTTGKLKAPGSSVAGQATVFIFPGISAGNIGYKIAERMGGFAAVGPVLQGLNQPVNDLSRGCNPDDVYNLTLITAVQALEHR
>NZ_CP012731.1|WP_002935240.1|2123307_2124201_-|RluA-family-pseudouridine-synthase
MRFEFIADQHTKIKTFLKKHGVSKGLLAKIKYTGGNIWVNDIEQNATYLLDIGDRVTIDIPAEEDLTGSLKPIFFPLDIVYEDDHFLSINKPVGYASIPSALHSSTIANFVKGYLIEQNYENKQVHIVTRLDRDTSGVMLFAKHGYAHARLDKQLQAKLIHKRYYALVKGNGQLEETGDIIAPIGRPEDSIITRCVTKNGKYAHTSYRVVQSWGDIHLVDIQLHTGRTHQIRVHFSHIGFPLLGDDMYGGSLECGIERQALHCHNLAFDNPFSAERIDLEAPLPEDFQAVINQLISK
>NZ_CP012731.1|WP_032497578.1|2124200_2125028_-|NAD-kinase
MIQMKNTGRKKIALLASRNPKSEAVSKELWTKLKEANFILTPKNPDIVISIGGDGMLLSAFHKYEKLIDRVRFVGIHTGHLGFYTDYRDFEVDKLIENLKLDTGARVSYPILNVKVKMTDGRIVEARALNEATVKRLSKTMVADIIINNVPFERFRGDGISVSTPTGSTAYNKSLGGAVLHPTIEALQIAEVASLNNRVYRTLGSSVVVPKKDKIVIEPKHSDRYSIAVDNKTFVYDSIESIEYQIDNSKIHFVATPSHTSFWNRVKDAFIGEVE
>NZ_CP012731.1|WP_002935242.1|2125002_2125674_-|GTP-pyrophosphokinase-family-protein
MDFNWEEFLDPYIQTVGELKIKLRGIRKQYRKANRHSPIEFVTGRVKPIESIKEKMALRHIKLENLAQDMQDIAGLRIMVQFVDDIEEVLAILRKRKDMQIVHERDYINNMKASGYRSYHVVIEYPVDTINGNETVLAEIQIRTLSMNFWATIEHSLNYKYKGNFPEEIKKRLEVTAKIAYELDEEMRKIRNDIQEAQALFDPAYRKLNDGVGNSDDTDEEYR
>NZ_CP012731.1|WP_002935243.1|2125760_2126327_+|CYTH-domain-containing-protein
MKNHLEIEYKTLLTKSEYKRLLTDFSDVSPILQTNHYIDTPDLDMKNHRFSLRIRTFEDSAELTLKIPQEVGNQEYNQVLDIQTAHDLLENFQLPAGQISDIISATEIPLDKLAVWGILTTKRYEKQTSIGLMALDENDYVGQKDYELEVEVTDADAGKILFDEFLKKKSIQFKYASSKVARTAAHMK
>NZ_CP012731.1|WP_009909926.1|2126471_2127449_+|ribose-phosphate-diphosphokinase
MVQPLGEHNIKLFSLNSNRDIAEKIADSAGIPLGKLSSRQFSDGEIQINIEESVRGVDVYIIQSTSYPVNNHLWELLIMIDACKRASANTITAVIPYFGYARQDRTASPREPITAKLVANMLVKAGVDRVLTLDLHASQIQGFFDIPVDNLLTEPLFAAYYMEKGLCGEDVVIVSPKNSGIKRARNIAEFLNAPIAIIDYAQDDSERSEGYIIGDVAGKKAILVDDILNTGRTFSQASKIVQEGGATEIYAVASHGLFAGTATQLLDEAPIKEILVTDSVASKEQHPKNIVFLTASDLIADAIHRIQEHQPLSPLFKFTSPEKEN
>NZ_CP012731.1|WP_002935247.1|2127459_2128575_+|cysteine-desulfurase
MIYLDNAATTALSPTALQRMMEVAQENYGNPSSIHQSGRKANQRLRQSRQEIAQILSASPEQIIFTSGGSEADTLAIQGYALAHQSKGKHLITTAIEHHAVLHTMQYLEERFGFEVTYIQPVDQVITAQQIQDALRPDTILVSVMFANNETGQLLPIKEIGELLADHQAVFHVDAVQAIGKIAISPSNYGIDLLAASAHKFHGPKGTGFLYSKVHKFDSLIHGGKQEQQHRAGTENLPAIAAMATALTEQYESLDTHHQHVSELRQHIIEGLSGLDYYLNQAGPHLPHVLNIGFPGKLNEQLLMQLDLAGIAVSSGSACTAGVVQNSHVLEAMYGKDSHRLKESIRISLSEINTKEEIDTLIIELKKILGG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP012731_1	1.7\|190384\|29\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190384-190412	29	NZ_CP012731.1	1929478-1929506	0	1.0

1. spacer 1.7|190384|29|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to position: 1929478-1929506, mismatch: 0, identity: 1.0

caacatggttttgatcccacgtttggcca	CRISPR spacer
caacatggttttgatcccacgtttggcca	Protospacer
*****************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP012731_1	1.3\|190121\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190121-190150	30	MK448982	Streptococcus phage Javan554, complete genome	21889-21918	0	1.0
NZ_CP012731_1	1.6\|190318\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190318-190347	30	MK448365	Streptococcus satellite phage Javan212, complete genome	12488-12517	6	0.8
NZ_CP012731_1	1.6\|190318\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190318-190347	30	NZ_CP026119	Halobacillus litoralis strain ERB 031 plasmid pLDW-31, complete sequence	127386-127415	6	0.8
NZ_CP012731_1	1.7\|190384\|29\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190384-190412	29	NZ_CP012032	Leptospira borgpetersenii serovar Ballum strain 56604 plasmid lbp2, complete sequence	6830-6858	6	0.793
NZ_CP012731_2	2.1\|2118367\|28\|NZ_CP012731\|CRISPRCasFinder	2118367-2118394	28	NZ_CP043555	Vibrio cholerae strain RFB16 plasmid unnamed, complete sequence	6368-6395	6	0.786
NZ_CP012731_1	1.1\|189989\|30\|NZ_CP012731\|CRISPRCasFinder,CRT	189989-190018	30	AJ609634	Bacteriophage EJ-1 proviral DNA, complete genome	6909-6938	7	0.767
NZ_CP012731_1	1.1\|189989\|30\|NZ_CP012731\|CRISPRCasFinder,CRT	189989-190018	30	NC_005294	Streptococcus prophage EJ-1, complete genome	6909-6938	7	0.767
NZ_CP012731_1	1.1\|189989\|30\|NZ_CP012731\|CRISPRCasFinder,CRT	189989-190018	30	KY065449	Streptococcus phage IPP5, complete genome	7026-7055	7	0.767
NZ_CP012731_1	1.3\|190121\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190121-190150	30	NZ_CP013208	Paenibacillus sp. IHB B 3084 plasmid pHD05, complete sequence	11448-11477	7	0.767
NZ_CP012731_1	1.3\|190121\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190121-190150	30	NZ_MG205643	Paeniclostridium sordellii strain S0804018 plasmid pCS1-5, complete sequence	56962-56991	7	0.767
NZ_CP012731_1	1.6\|190318\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190318-190347	30	AP019559	Escherichia phage SP15 DNA, complete genome	91136-91165	7	0.767
NZ_CP012731_1	1.6\|190318\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190318-190347	30	NZ_CP014221	Clostridium botulinum strain B515 plasmid pRSJ21_2, complete sequence	10259-10288	7	0.767
NZ_CP012731_1	1.6\|190318\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190318-190347	30	NZ_CP013852	Clostridium botulinum strain B305 plasmid pRSJ6_2, complete sequence	8743-8772	7	0.767
NZ_CP012731_1	1.6\|190318\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190318-190347	30	NZ_CP014172	Clostridium botulinum strain B609 plasmid pRSJ22_1, complete sequence	744-773	7	0.767
NZ_CP012731_2	2.1\|2118367\|28\|NZ_CP012731\|CRISPRCasFinder	2118367-2118394	28	NZ_CP040462	Enterococcus sp. M190262 plasmid pM190262, complete sequence	148656-148683	7	0.75
NZ_CP012731_1	1.6\|190318\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190318-190347	30	MT679222	Proteus phage 2, complete genome	96921-96950	8	0.733
NZ_CP012731_1	1.6\|190318\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190318-190347	30	MT679223	Proteus phage 1, complete genome	97178-97207	8	0.733
NZ_CP012731_1	1.6\|190318\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190318-190347	30	NZ_CP053952	Bacillus cereus strain FDAARGOS_798 plasmid unnamed1, complete sequence	451906-451935	8	0.733
NZ_CP012731_1	1.6\|190318\|30\|NZ_CP012731\|CRISPRCasFinder,CRT,PILER-CR	190318-190347	30	NZ_CP053949	Bacillus cereus strain FDAARGOS_799 plasmid unnamed1, complete sequence	101964-101993	8	0.733

1. spacer 1.3|190121|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to MK448982 (Streptococcus phage Javan554, complete genome) position: , mismatch: 0, identity: 1.0

gacaaggtcgaaaagaaatacattgatgtt	CRISPR spacer
gacaaggtcgaaaagaaatacattgatgtt	Protospacer
******************************

2. spacer 1.6|190318|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to MK448365 (Streptococcus satellite phage Javan212, complete genome) position: , mismatch: 6, identity: 0.8

cagtattaattgggatattatttatcttag	CRISPR spacer
tagtattaattggaatagtatttatctctt	Protospacer
.************.*** *********.

3. spacer 1.6|190318|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP026119 (Halobacillus litoralis strain ERB 031 plasmid pLDW-31, complete sequence) position: , mismatch: 6, identity: 0.8

cagtattaattgggatattatttatcttag	CRISPR spacer
gagtattaattgggttattatttattgttc	Protospacer
 ************* **********. *

4. spacer 1.7|190384|29|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP012032 (Leptospira borgpetersenii serovar Ballum strain 56604 plasmid lbp2, complete sequence) position: , mismatch: 6, identity: 0.793

caacatggttttgatcccacgtttggcca	CRISPR spacer
aaaatcggtttttttcccacgtttggcca	Protospacer
 **  .******  ***************

5. spacer 2.1|2118367|28|NZ_CP012731|CRISPRCasFinder matches to NZ_CP043555 (Vibrio cholerae strain RFB16 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.786

catttctacaaaggtttggggaaacttg	CRISPR spacer
aatttctacaaagttttggggaaggtat	Protospacer
 ************ *********. *

6. spacer 1.1|189989|30|NZ_CP012731|CRISPRCasFinder,CRT matches to AJ609634 (Bacteriophage EJ-1 proviral DNA, complete genome) position: , mismatch: 7, identity: 0.767

tacaaatgttatggggataactaccagaag	CRISPR spacer
taaaaatgttaaggggataactaaagaaac	Protospacer
** ******** ***********  ..**

7. spacer 1.1|189989|30|NZ_CP012731|CRISPRCasFinder,CRT matches to NC_005294 (Streptococcus prophage EJ-1, complete genome) position: , mismatch: 7, identity: 0.767

tacaaatgttatggggataactaccagaag	CRISPR spacer
taaaaatgttaaggggataactaaagaaac	Protospacer
** ******** ***********  ..**

8. spacer 1.1|189989|30|NZ_CP012731|CRISPRCasFinder,CRT matches to KY065449 (Streptococcus phage IPP5, complete genome) position: , mismatch: 7, identity: 0.767

tacaaatgttatggggataactaccagaag	CRISPR spacer
taaaaatgttaaggggataactaaagaaac	Protospacer
** ******** ***********  ..**

9. spacer 1.3|190121|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP013208 (Paenibacillus sp. IHB B 3084 plasmid pHD05, complete sequence) position: , mismatch: 7, identity: 0.767

gacaaggtcgaaaagaaatacattgatgtt	CRISPR spacer
aagcaggacgaaaagaaatccattgatgca	Protospacer
.*  *** *********** ********.

10. spacer 1.3|190121|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to NZ_MG205643 (Paeniclostridium sordellii strain S0804018 plasmid pCS1-5, complete sequence) position: , mismatch: 7, identity: 0.767

gacaaggtcgaaaagaaatacattgatgtt	CRISPR spacer
gatacacccgaaaagaaagacattgatgtc	Protospacer
**.* . .********** **********.

11. spacer 1.6|190318|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to AP019559 (Escherichia phage SP15 DNA, complete genome) position: , mismatch: 7, identity: 0.767

cagtattaattgggatattatttatcttag	CRISPR spacer
cagtatttaatgggatattatttagaacaa	Protospacer
******* * **************   .*.

12. spacer 1.6|190318|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP014221 (Clostridium botulinum strain B515 plasmid pRSJ21_2, complete sequence) position: , mismatch: 7, identity: 0.767

cagtattaattgggatattatttatcttag	CRISPR spacer
taagactaattgggatagtatttttcttat	Protospacer
.*. *.*********** ***** *****

13. spacer 1.6|190318|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP013852 (Clostridium botulinum strain B305 plasmid pRSJ6_2, complete sequence) position: , mismatch: 7, identity: 0.767

cagtattaattgggatattatttatcttag	CRISPR spacer
taagactaattgggatagtatttttcttat	Protospacer
.*. *.*********** ***** *****

14. spacer 1.6|190318|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP014172 (Clostridium botulinum strain B609 plasmid pRSJ22_1, complete sequence) position: , mismatch: 7, identity: 0.767

cagtattaattgggatattatttatcttag	CRISPR spacer
taagactaattgggatagtatttttcttat	Protospacer
.*. *.*********** ***** *****

15. spacer 2.1|2118367|28|NZ_CP012731|CRISPRCasFinder matches to NZ_CP040462 (Enterococcus sp. M190262 plasmid pM190262, complete sequence) position: , mismatch: 7, identity: 0.75

catttctacaaaggtttggggaaacttg	CRISPR spacer
catttctacaacggtttgcggaacaaat	Protospacer
*********** ****** ****

16. spacer 1.6|190318|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to MT679222 (Proteus phage 2, complete genome) position: , mismatch: 8, identity: 0.733

cagtattaattgggatattatttatcttag	CRISPR spacer
tcgtattagttgggatattagttatccgta	Protospacer
. ******.*********** *****.  .

17. spacer 1.6|190318|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to MT679223 (Proteus phage 1, complete genome) position: , mismatch: 8, identity: 0.733

cagtattaattgggatattatttatcttag	CRISPR spacer
tcgtattagttgggatattagttatccgta	Protospacer
. ******.*********** *****.  .

18. spacer 1.6|190318|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP053952 (Bacillus cereus strain FDAARGOS_798 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

cagtattaattgggatattatttatcttag	CRISPR spacer
agagattgattgggatattttttatcttga	Protospacer
 .. ***.*********** ********..

19. spacer 1.6|190318|30|NZ_CP012731|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP053949 (Bacillus cereus strain FDAARGOS_799 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

cagtattaattgggatattatttatcttag	CRISPR spacer
agagattgattgggatattttttatcttga	Protospacer
 .. ***.*********** ********..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

102855 : 153464

Streptococcus_phage(30.0%)

protease,tRNA,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002935153.1\|102855_104058_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	3.2e-213	93.8
WP_009910073.1\|104350_107845_-	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_009910076.1\|107941_108250_-	preprotein translocase subunit YajC	NA	NA	NA	NA
WP_002936073.1\|108256_109072_-	PTS mannose/fructose/sorbose transporter family subunit IID	NA	NA	NA	NA
WP_002936077.1\|109058_109835_-	PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC	NA	NA	NA	NA
WP_002936080.1\|109854_110346_-	PTS system mannose/fructose/N-acetylgalactosamine-transporter subunit IIB	NA	NA	NA	NA
WP_002936082.1\|110355_111546_-	glycoside hydrolase family 88 protein	NA	NA	NA	NA
WP_002936085.1\|111557_111992_-	PTS sugar transporter subunit IIA	NA	NA	NA	NA
WP_022540650.1\|112277_112919_-	bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase	NA	NA	NA	NA
WP_002936090.1\|112929_113931_-	sugar kinase	NA	NA	NA	NA
WP_002936092.1\|113947_114589_-	RpiB/LacA/LacB family sugar-phosphate isomerase	NA	NA	NA	NA
WP_002936093.1\|114640_115456_-	gluconate 5-dehydrogenase	NA	NA	NA	NA
WP_002936094.1\|116366_117461_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_002936095.1\|117568_118243_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_002936096.1\|118252_118570_-	hypothetical protein	NA	NA	NA	NA
WP_012775187.1\|118579_119269_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_009910094.1\|119294_119501_-	hypothetical protein	NA	NA	NA	NA
WP_013730414.1\|119522_120281_-	DUF3169 family protein	NA	NA	NA	NA
WP_009910096.1\|120277_120493_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013730415.1\|120505_121072_-	DUF3267 domain-containing protein	NA	NA	NA	NA
WP_002938096.1\|121222_121417_-	hypothetical protein	NA	NA	NA	NA
WP_002938097.1\|121620_122073_-	cytidine deaminase	NA	NA	NA	NA
WP_009910105.1\|122147_124766_-\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	1.5e-61	34.2
WP_002938099.1\|125045_125531_-	LURP-one-related family protein	NA	NA	NA	NA
WP_002938100.1\|125795_126797_-	peptidylprolyl isomerase PrsA	NA	NA	NA	NA
WP_009910106.1\|126857_127577_-	O-methyltransferase	NA	NA	NA	NA
WP_002938103.1\|127651_128200_-	hypothetical protein	NA	NA	NA	NA
WP_002938105.1\|128215_128656_-	hypothetical protein	NA	NA	NA	NA
WP_009910108.1\|128657_130460_-	oligoendopeptidase F	NA	NA	NA	NA
WP_002938107.1\|130691_131633_-	competence protein CoiA	NA	NA	NA	NA
WP_074390814.1\|131696_133754_-\|tRNA	methionine--tRNA ligase	A0A1V0SEZ7	Hokovirus	5.8e-85	31.1
WP_002938116.1\|133853_134447_+	DUF1361 domain-containing protein	NA	NA	NA	NA
WP_002938119.1\|134747_135785_+	3-deoxy-7-phosphoheptulonate synthase	S4W5F1	Pandoravirus	2.2e-45	34.3
WP_002938121.1\|135794_136820_+	3-deoxy-7-phosphoheptulonate synthase	S4W5F1	Pandoravirus	3.2e-44	35.2
WP_002938123.1\|136865_137735_+	shikimate dehydrogenase	NA	NA	NA	NA
WP_002938125.1\|137747_138815_+	3-dehydroquinate synthase	NA	NA	NA	NA
WP_002938126.1\|139018_139819_-	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	9.0e-10	23.8
WP_013730419.1\|139828_140722_-	ABC transporter permease	NA	NA	NA	NA
WP_013730420.1\|140776_141751_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013730421.1\|141774_142734_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013730422.1\|143474_144476_-	tagatose-bisphosphate aldolase	NA	NA	NA	NA
WP_013730423.1\|144499_145645_-	N-acetylglucosamine-6-phosphate deacetylase	NA	NA	NA	NA
WP_002935153.1\|146024_147227_+\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	3.2e-213	93.8
WP_024390310.1\|147775_148606_-	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_009909533.1\|148632_149265_-	amino acid ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	6.6e-32	38.9
WP_013730426.1\|149274_149916_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_013730427.1\|150089_151901_-	glutamine--fructose-6-phosphate transaminase (isomerizing)	Q84421	Paramecium_bursaria_Chlorella_virus	9.5e-100	37.6
WP_013730428.1\|152207_153464_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	7.5e-128	56.4

DBSCAN-SWA_2

236910 : 251450

Streptococcus_phage(100.0%)

integrase

attL 238730:238746|attR 248186:248202

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002935693.1\|236910_237096_+	hypothetical protein	W6LMT3	Streptococcus_phage	2.3e-17	68.9
WP_062897072.1\|237128_237770_-	HAD family hydrolase	NA	NA	NA	NA
WP_009910443.1\|237936_238197_-	type II toxin-antitoxin system RelE/ParE family toxin	A0A1S5S8E8	Streptococcus_phage	3.9e-23	55.8
WP_012775256.1\|238198_238420_-	hypothetical protein	A0A1X9I609	Streptococcus_phage	1.2e-33	100.0
238730:238746	attL	NA	NA	NA	NA
WP_009910447.1\|239526_239736_-	hypothetical protein	A0A1X9I6N3	Streptococcus_phage	1.0e-34	100.0
WP_009910448.1\|239847_240300_-	type II toxin-antitoxin system HicB family antitoxin	A0A1X9I727	Streptococcus_phage	1.7e-82	100.0
WP_009910449.1\|240339_240522_-	type II toxin-antitoxin system HicA family toxin	A0A1X9I5W4	Streptococcus_phage	3.7e-28	100.0
WP_009910450.1\|240705_241092_-	hypothetical protein	A0A1X9I5X3	Streptococcus_phage	4.6e-60	100.0
WP_024409209.1\|241231_241732_-	hypothetical protein	A0A1X9I5V2	Streptococcus_phage	1.3e-94	100.0
WP_024409208.1\|241801_242242_-	hypothetical protein	A0A1X9I5V5	Streptococcus_phage	2.0e-75	100.0
WP_024409207.1\|242709_243555_-	ATP-binding protein	A0A1X9I6C4	Streptococcus_phage	2.6e-156	100.0
WP_079269917.1\|243570_244365_-	DnaD domain protein	A0A1X9I617	Streptococcus_phage	1.3e-149	100.0
WP_024409205.1\|244378_244594_-	hypothetical protein	A0A1X9I5W7	Streptococcus_phage	2.4e-34	100.0
WP_162841287.1\|244598_244757_-	hypothetical protein	A0A1X9I5Z1	Streptococcus_phage	3.1e-23	100.0
WP_024409204.1\|244767_245034_-	hypothetical protein	A0A1X9I6M4	Streptococcus_phage	5.6e-41	100.0
WP_024409203.1\|245044_245248_-	hypothetical protein	A0A1X9I725	Streptococcus_phage	2.8e-29	100.0
WP_024409202.1\|245240_245444_-	hypothetical protein	A0A1X9I5V6	Streptococcus_phage	4.4e-30	100.0
WP_024409201.1\|245433_245709_-	hypothetical protein	A0A1X9I5W5	Streptococcus_phage	8.0e-43	100.0
WP_024409200.1\|245887_246076_-	hypothetical protein	A0A1X9I5U7	Streptococcus_phage	7.2e-27	100.0
WP_024409199.1\|246233_246779_+	helix-turn-helix transcriptional regulator	A0A1X9I5U6	Streptococcus_phage	9.5e-96	100.0
WP_024415669.1\|246862_248026_+\|integrase	site-specific integrase	A0A1X9I6A9	Streptococcus_phage	9.7e-223	99.7
WP_002935704.1\|248185_249493_-	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	8.3e-247	100.0
248186:248202	attR	NA	NA	NA	NA
WP_013730449.1\|249642_250095_+	DUF1694 domain-containing protein	NA	NA	NA	NA
WP_002935708.1\|250104_250332_-	hypothetical protein	NA	NA	NA	NA
WP_002935718.1\|250322_251450_-	glycerate kinase	W6LM47	Streptococcus_phage	5.7e-87	58.0

DBSCAN-SWA_3

508070 : 523847

Streptococcus_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002935370.1\|508070_508898_+	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	8.3e-152	99.6
WP_009909675.1\|509197_510097_+	cation transporter	M1Q1N9	Streptococcus_phage	1.3e-161	98.3
WP_002935368.1\|510113_510467_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.9e-60	100.0
WP_002935366.1\|510450_510957_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.2e-92	97.0
WP_002935365.1\|510959_512141_-	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	2.7e-220	99.7
WP_002935364.1\|512514_513072_-	GNAT family acetyltransferase	M1PSC3	Streptococcus_phage	4.5e-93	98.4
WP_002935363.1\|513071_514163_-	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	1.5e-204	98.6
WP_002935362.1\|514632_515496_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	2.1e-158	99.7
WP_002935361.1\|515497_515815_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	3.1e-54	100.0
WP_002935359.1\|515834_516719_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	3.6e-153	98.3
WP_002935358.1\|516715_517354_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.6e-113	98.6
WP_002935357.1\|517528_518395_+	YitT family protein	M1Q1P6	Streptococcus_phage	4.6e-153	99.7
WP_002935355.1\|518431_519703_-	toxic anion resistance protein	M1PLC8	Streptococcus_phage	1.7e-212	100.0
WP_002935354.1\|519708_520536_-	hypothetical protein	M1PFV6	Streptococcus_phage	6.6e-133	97.8
WP_002935353.1\|520629_521286_-	CBS domain-containing protein	M1NSC5	Streptococcus_phage	2.1e-113	99.1
WP_002935351.1\|521464_521608_-\|transposase	transposase	NA	NA	NA	NA
WP_009909666.1\|521609_523847_-	DNA internalization-related competence protein ComEC/Rec2	M1PSD2	Streptococcus_phage	1.4e-97	94.0

DBSCAN-SWA_4

602434 : 638332

Streptococcus_phage(97.67%)

portal,integrase,transposase

attL 629766:629780|attR 638142:638156

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_009909562.1\|602434_603112_-	tyrosine-protein kinase	A0A1X9I5D6	Streptococcus_phage	1.6e-121	100.0
WP_011922111.1\|603121_603811_-	capsular polysaccharide biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	1.3e-110	96.1
WP_024409273.1\|603828_605274_-	LCP family protein	A0A1X9I5X1	Streptococcus_phage	1.6e-227	99.8
WP_012775019.1\|605378_606113_-	peroxide stress protein YaaA	A0A1X9I5I0	Streptococcus_phage	1.5e-120	99.5
WP_024409272.1\|606234_607494_+	PLP-dependent aminotransferase family protein	A0A1X9I5H2	Streptococcus_phage	7.0e-243	100.0
WP_013730272.1\|607592_608444_-	DegV family protein	A0A1X9I5J4	Streptococcus_phage	6.3e-155	100.0
WP_013730271.1\|608570_608975_+	TetR/AcrR family transcriptional regulator	A0A1X9I6A2	Streptococcus_phage	1.1e-64	100.0
WP_009909545.1\|608997_609783_-	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	1.6e-136	100.0
WP_009909544.1\|609792_611031_-	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	1.2e-223	100.0
WP_013730270.1\|611095_612172_-	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	2.1e-195	100.0
WP_024409271.1\|612333_614847_-	bifunctional DnaQ family exonuclease/ATP-dependent helicase	A0A1X9I5C8	Streptococcus_phage	0.0e+00	100.0
WP_009909540.1\|614909_615548_+	MBL fold metallo-hydrolase	A0A1X9I5D3	Streptococcus_phage	4.6e-126	100.0
WP_162487885.1\|617172_618465_+\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	1.3e-212	93.5
WP_022540567.1\|618666_618900_-	hypothetical protein	A0A1X9I5G0	Streptococcus_phage	1.6e-39	100.0
WP_013730185.1\|620117_621383_-\|portal	phage portal protein	A0A1X9I693	Streptococcus_phage	5.4e-243	100.0
WP_024409219.1\|621379_621739_-	hypothetical protein	A0A1X9I6S2	Streptococcus_phage	9.8e-41	99.2
WP_013730183.1\|621830_622178_-	HNH endonuclease	A0A1X9I5C9	Streptococcus_phage	1.3e-61	100.0
WP_002937915.1\|622274_622709_-	DUF1492 domain-containing protein	A0A1X9I5B5	Streptococcus_phage	2.0e-72	100.0
WP_013730182.1\|622781_623096_-	hypothetical protein	A0A1X9I5C1	Streptococcus_phage	5.2e-54	100.0
WP_013730181.1\|623284_623500_-	hypothetical protein	A0A1X9I5W1	Streptococcus_phage	9.7e-36	100.0
WP_013730180.1\|623501_623810_-	DUF1372 family protein	A0A1X9I5G5	Streptococcus_phage	3.8e-49	100.0
WP_013730179.1\|623806_623962_-	hypothetical protein	A0A1X9I5E8	Streptococcus_phage	9.7e-22	100.0
WP_079253058.1\|624339_625719_-	helicase	A0A1X9I5H6	Streptococcus_phage	3.8e-266	99.8
WP_013730177.1\|625702_626530_-	bifunctional DNA primase/polymerase	A0A1X9I684	Streptococcus_phage	4.6e-158	100.0
WP_022540565.1\|626540_626939_-	single-stranded DNA-binding protein	A0A1X9I6R5	Streptococcus_phage	2.7e-68	100.0
WP_022540564.1\|626935_627232_-	hypothetical protein	A0A1X9I5B1	Streptococcus_phage	1.6e-52	100.0
WP_013730175.1\|627231_627930_-	ERF family protein	A0A1X9I5A9	Streptococcus_phage	2.2e-113	100.0
WP_013730173.1\|628279_629452_-	hypothetical protein	M1PF69	Streptococcus_phage	7.0e-229	98.7
WP_013730172.1\|629420_629885_-	hypothetical protein	A0A1X9I5S7	Streptococcus_phage	7.1e-84	100.0
629766:629780	attL	NA	NA	NA	NA
WP_013730171.1\|629865_630111_-	hypothetical protein	A0A1X9I5F0	Streptococcus_phage	4.3e-40	100.0
WP_013730170.1\|630107_630587_-	siphovirus Gp157 family protein	A0A1X9I5D2	Streptococcus_phage	4.8e-67	100.0
WP_013730169.1\|630586_630928_-	hypothetical protein	A0A1X9I5G6	Streptococcus_phage	2.1e-56	100.0
WP_022540561.1\|630932_631085_-	hypothetical protein	A0A1X9I663	Streptococcus_phage	2.0e-19	100.0
WP_013730168.1\|631074_631323_-	hypothetical protein	A0A1X9I6Q0	Streptococcus_phage	1.1e-38	100.0
WP_013730167.1\|631363_631618_-	hypothetical protein	A0A1X9I581	Streptococcus_phage	9.7e-43	100.0
WP_013730166.1\|631691_632018_-	hypothetical protein	A0A1X9I594	Streptococcus_phage	8.0e-58	100.0
WP_002937001.1\|632087_632288_-	helix-turn-helix transcriptional regulator	A0A1X9I583	Streptococcus_phage	9.6e-30	100.0
WP_002937004.1\|632472_632853_+	helix-turn-helix transcriptional regulator	A0A1X9I5A1	Streptococcus_phage	3.9e-64	100.0
WP_013730165.1\|632859_633243_+	ImmA/IrrE family metallo-endopeptidase	A0A1X9I5R2	Streptococcus_phage	2.9e-67	100.0
WP_013730164.1\|633290_634022_+	hypothetical protein	A0A1X9I5E4	Streptococcus_phage	3.7e-103	100.0
WP_024409220.1\|634218_635376_+\|integrase	site-specific integrase	A0A1X9I5C3	Streptococcus_phage	2.2e-219	100.0
WP_002937015.1\|635605_636532_+	cysteine synthase A	A0A1X9I5F1	Streptococcus_phage	9.9e-170	100.0
WP_002937017.1\|636558_636930_-	S1 RNA-binding domain-containing protein	NA	NA	NA	NA
WP_002937018.1\|636931_638332_-	Cof-type HAD-IIB family hydrolase	A0A1V0S9I2	Catovirus	2.3e-24	43.5
638142:638156	attR	NA	NA	NA	NA

DBSCAN-SWA_5

1071469 : 1089478

Streptococcus_phage(72.22%)

integrase,transposase

attL 1076349:1076367|attR 1088176:1088194

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014637236.1\|1071469_1072951_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	3.6e-97	41.9
WP_086558053.1\|1073111_1074404_+\|transposase	IS110-like element ISSsu7 family transposase	A0A1X9I619	Streptococcus_phage	1.4e-225	100.0
WP_002936177.1\|1074843_1075938_-	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_002936175.1\|1075940_1076324_-	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	4.6e-36	94.5
1076349:1076367	attL	NA	NA	NA	NA
WP_013730693.1\|1076461_1077634_-\|integrase	site-specific integrase	A0A1X9I5Y5	Streptococcus_phage	3.1e-216	96.9
WP_013730692.1\|1077798_1078629_-	KilA-N domain-containing protein	Q4ZC41	Staphylococcus_virus	1.2e-89	62.1
WP_013730691.1\|1078992_1079706_-	helix-turn-helix transcriptional regulator	Q708R9	Streptococcus_phage	3.7e-15	50.6
WP_013730690.1\|1079859_1080087_+	helix-turn-helix transcriptional regulator	Q38329	Lactococcus_phage	2.8e-09	51.6
WP_013730689.1\|1080105_1080852_+	Bro-N domain-containing protein	A0A0A7RW33	Clostridium_phage	2.1e-24	50.7
WP_013730688.1\|1080864_1081491_+	Rha family transcriptional regulator	A0A192Y918	Salmonella_phage	9.5e-15	32.8
WP_013730687.1\|1081929_1082319_+	hypothetical protein	NA	NA	NA	NA
WP_013730686.1\|1082306_1082510_+	hypothetical protein	A0A1X9I5T6	Streptococcus_phage	7.2e-25	79.1
WP_013730685.1\|1082521_1082671_+	hypothetical protein	A0A1X9I6A8	Streptococcus_phage	2.4e-17	89.8
WP_024409270.1\|1082667_1083006_+	hypothetical protein	A0A1X9I5Z6	Streptococcus_phage	5.1e-47	97.8
WP_013730683.1\|1082995_1083280_+	hypothetical protein	A0A1X9I5U9	Streptococcus_phage	8.9e-37	83.9
WP_013730682.1\|1083266_1084082_+	DnaD domain protein	A0A2I6QQV2	Streptococcus_phage	2.0e-81	66.0
WP_013730681.1\|1084094_1084553_+	hypothetical protein	A0A1X9I5V5	Streptococcus_phage	7.6e-22	42.0
WP_013730680.1\|1084630_1085179_+	hypothetical protein	A0A1X9I5U4	Streptococcus_phage	4.7e-50	58.1
WP_172792758.1\|1085867_1087160_+\|transposase	IS110-like element ISSsu7 family transposase	A0A1X9I619	Streptococcus_phage	6.8e-225	99.8
WP_024381289.1\|1087465_1087807_+	DUF1492 domain-containing protein	NA	NA	NA	NA
WP_009911054.1\|1088224_1089478_+	insulinase family protein	A0A1X9I714	Streptococcus_phage	4.2e-232	99.0
1088176:1088194	attR	NA	NA	NA	NA

DBSCAN-SWA_6

1758035 : 1794923

Streptococcus_phage(93.33%)

transposase,holin,protease,capsid,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004194722.1\|1758035_1760210_-	LTA synthase family protein	W6LM83	Streptococcus_phage	1.1e-230	60.3
WP_004194720.1\|1760325_1761489_+	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	2.1e-140	64.7
WP_004194719.1\|1761485_1762160_+	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	7.7e-79	64.6
WP_004194717.1\|1762163_1763330_+	chorismate synthase	A0A291AU41	Pandoravirus	3.5e-39	34.9
WP_013730266.1\|1763337_1764441_+	prephenate dehydrogenase	NA	NA	NA	NA
WP_002938966.1\|1764450_1764789_+	YlbF/YmcA family competence regulator	A0A1X9I5Y8	Streptococcus_phage	1.9e-54	100.0
WP_002935153.1\|1765091_1766294_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	3.2e-213	93.8
WP_024390460.1\|1766568_1766823_+	hypothetical protein	A0A1X9I5Y1	Streptococcus_phage	1.2e-40	100.0
WP_024390459.1\|1766822_1767053_+	hypothetical protein	A0A1X9I6E9	Streptococcus_phage	4.8e-33	100.0
WP_024409245.1\|1767136_1768552_+\|terminase	terminase	A0A1X9I637	Streptococcus_phage	1.2e-267	100.0
WP_024409244.1\|1768632_1769097_+	DUF4355 domain-containing protein	A0A1X9I604	Streptococcus_phage	5.5e-76	100.0
WP_024390456.1\|1769100_1769991_+\|capsid	phage major capsid protein	M1PF50	Streptococcus_phage	6.8e-168	100.0
WP_024409243.1\|1769992_1770211_+	hypothetical protein	A0A1X9I6Q1	Streptococcus_phage	8.6e-32	100.0
WP_024409242.1\|1770214_1770610_+	hypothetical protein	A0A1X9I730	Streptococcus_phage	3.7e-65	100.0
WP_024409241.1\|1770596_1770935_+	hypothetical protein	A0A1X9I5Z3	Streptococcus_phage	4.7e-61	100.0
WP_024409240.1\|1770927_1771167_+	hypothetical protein	A0A1X9I5Y4	Streptococcus_phage	4.8e-36	100.0
WP_024409239.1\|1771163_1771499_+	hypothetical protein	A0A1X9I5X7	Streptococcus_phage	6.5e-55	100.0
WP_024409238.1\|1771514_1772102_+	hypothetical protein	A0A1X9I5X2	Streptococcus_phage	3.3e-102	100.0
WP_024415622.1\|1772112_1772391_+	hypothetical protein	M1Q1D2	Streptococcus_phage	3.6e-43	100.0
WP_024409236.1\|1772387_1772771_+	DUF5361 domain-containing protein	A0A1X9I625	Streptococcus_phage	3.6e-65	100.0
WP_002937855.1\|1772760_1775343_+	hypothetical protein	M1NRZ6	Streptococcus_phage	6.2e-262	100.0
WP_002937853.1\|1775342_1776038_+	adenylosuccinate synthetase	M1PFK1	Streptococcus_phage	5.8e-130	100.0
WP_024409235.1\|1776034_1781341_+	hypothetical protein	A0A1X9I6P1	Streptococcus_phage	0.0e+00	100.0
WP_024409234.1\|1781340_1781556_+	hypothetical protein	A0A1X9I729	Streptococcus_phage	4.3e-28	100.0
WP_024409233.1\|1781558_1781903_+	hypothetical protein	A0A1X9I5X6	Streptococcus_phage	6.7e-63	100.0
WP_029743088.1\|1781948_1782335_+\|holin	phage holin family protein	A0A1X9I5Y2	Streptococcus_phage	1.1e-61	100.0
WP_024409231.1\|1782431_1783169_+	PlySs2 family phage lysin	A0A1X9I5W6	Streptococcus_phage	1.9e-139	100.0
WP_024394270.1\|1783233_1783611_+	hypothetical protein	A0A1X9I733	Streptococcus_phage	1.9e-63	100.0
WP_162096930.1\|1784012_1785305_+\|transposase	IS110-like element ISSsu7 family transposase	A0A1X9I619	Streptococcus_phage	8.8e-225	99.8
WP_002935451.1\|1785519_1787310_-	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	0.0e+00	100.0
WP_002935455.1\|1787476_1787815_+	hypothetical protein	NA	NA	NA	NA
WP_002935458.1\|1787999_1789367_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_009909707.1\|1789656_1791936_+	DNA helicase PcrA	A7KV33	Bacillus_phage	1.2e-128	41.0
WP_009909709.1\|1792377_1793118_+	hypothetical protein	NA	NA	NA	NA
WP_013730335.1\|1793396_1794080_+	noncanonical pyrimidine nucleotidase, YjjG family	NA	NA	NA	NA
WP_013730336.1\|1794158_1794923_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_7

1951334 : 1964773

Streptococcus_phage(71.43%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_024383728.1\|1951334_1952027_+	helix-turn-helix transcriptional regulator	A0A1B0RXB1	Streptococcus_phage	1.3e-86	72.5
WP_024383729.1\|1952169_1953585_+	Y-family DNA polymerase	Q6DMX4	Streptococcus_phage	1.2e-198	71.8
WP_024383730.1\|1953581_1953932_+	hypothetical protein	M1PLN9	Streptococcus_phage	4.3e-25	51.6
WP_024383731.1\|1953918_1954212_+	hypothetical protein	E4ZFJ0	Streptococcus_phage	6.3e-30	64.6
WP_024383732.1\|1954258_1954897_-	single-stranded DNA-binding protein	NA	NA	NA	NA
WP_024406080.1\|1954893_1962165_-	DEAD/DEAH box helicase family protein	A0A248SL14	Klebsiella_phage	4.1e-287	37.4
WP_050571928.1\|1962183_1962555_-	hypothetical protein	NA	NA	NA	NA
WP_024406079.1\|1962632_1963592_-	DNA cytosine methyltransferase	D2IZY5	Enterococcus_phage	7.3e-75	49.5
WP_029742340.1\|1963588_1964773_-	DNA (cytosine-5-)-methyltransferase	A0A141E1L1	Streptococcus_phage	1.4e-123	58.4

DBSCAN-SWA_8

2007539 : 2028559

Streptococcus_phage(86.67%)

terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062897132.1\|2007539_2008013_-\|terminase	phage terminase small subunit P27 family	A0A1X9I6K0	Streptococcus_phage	1.4e-79	92.4
WP_044693299.1\|2008072_2008363_-	hypothetical protein	NA	NA	NA	NA
WP_062897133.1\|2008346_2008745_-	hypothetical protein	NA	NA	NA	NA
WP_062897134.1\|2008726_2010070_-	hypothetical protein	NA	NA	NA	NA
WP_062897135.1\|2010069_2010459_-	hypothetical protein	NA	NA	NA	NA
WP_062897136.1\|2010565_2010931_-	HNH endonuclease	A0A1B0RXJ3	Streptococcus_phage	2.1e-67	94.2
WP_062897137.1\|2010955_2011327_-	hypothetical protein	D0R0C2	Streptococcus_phage	1.2e-57	96.5
WP_079764356.1\|2012429_2013293_-	zeta toxin family protein	NA	NA	NA	NA
WP_000301765.1\|2013294_2013567_-	antitoxin	A0A1X9I6E5	Streptococcus_phage	5.0e-05	100.0
WP_000527317.1\|2013583_2013793_-	peptide-binding protein	A0A1X9I6D5	Streptococcus_phage	6.3e-32	100.0
WP_001809760.1\|2013890_2014787_-	ParA family protein	A0A1X9I765	Streptococcus_phage	1.9e-154	99.3
WP_073459356.1\|2014889_2015174_-	topoisomerase DNA-binding C4 zinc finger domain-containing protein	A0A1X9I6W8	Streptococcus_phage	2.3e-40	93.0
WP_001038796.1\|2015319_2016057_-	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	E4ZFQ0	Streptococcus_phage	2.4e-134	99.6
WP_062897138.1\|2016181_2016277_-	23S rRNA methyltransferase attenuation leader peptide	NA	NA	NA	NA
WP_002935077.1\|2016297_2016462_-	peptide-binding protein	A0A1X9I6D5	Streptococcus_phage	1.0e-13	97.4
WP_002352589.1\|2016587_2018732_-	type IA DNA topoisomerase	A0A1X9I6W8	Streptococcus_phage	2.4e-267	97.8
WP_002321671.1\|2018731_2019349_-	recombinase family protein	A0A219YA40	Aeromonas_phage	2.9e-16	37.2
WP_011528024.1\|2019744_2019918_-	cysteine-rich KTR domain-containing protein	D0R0F6	Streptococcus_phage	1.7e-27	98.2
WP_000691759.1\|2019969_2021889_-	tetracycline resistance ribosomal protection protein Tet(O)	A0A1B0RXH7	Streptococcus_phage	0.0e+00	99.7
WP_024399226.1\|2022255_2022630_-	TnpV protein	D0R0F4	Streptococcus_phage	1.9e-63	96.0
WP_062897139.1\|2022610_2028559_-	N-6 DNA methylase	A0A248SL14	Klebsiella_phage	5.4e-176	31.3

DBSCAN-SWA_9

2048354 : 2058555

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062897147.1\|2048354_2049710_-	DNA (cytosine-5-)-methyltransferase	A0A141E1L1	Streptococcus_phage	5.2e-127	55.9
WP_024408847.1\|2049861_2050677_-	replication initiator protein A	A0A286QNA4	Streptococcus_phage	2.8e-11	36.6
WP_032497901.1\|2050679_2050847_-	hypothetical protein	NA	NA	NA	NA
WP_002936483.1\|2051046_2051412_-	50S ribosomal protein L7/L12	NA	NA	NA	NA
WP_002936486.1\|2051477_2051972_-	50S ribosomal protein L10	NA	NA	NA	NA
WP_062897148.1\|2052548_2054642_-	type I DNA topoisomerase	A0A1V0SCS0	Indivirus	9.0e-102	36.3
WP_009909860.1\|2054734_2055577_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	4.7e-33	44.3
WP_009909862.1\|2055635_2056193_-	sugar O-acetyltransferase	A0A191KBJ5	Streptococcus_virus	4.9e-07	38.6
WP_009909865.1\|2056203_2056464_-	metal-sensitive transcriptional regulator	NA	NA	NA	NA
WP_002936495.1\|2056582_2056906_+	rhodanese-like domain-containing protein	NA	NA	NA	NA
WP_002936496.1\|2056902_2058555_+	FAD-dependent oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	6.2e-13	24.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP012731

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection