CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	2 crisprs	NA	0	6	0	0
NZ_CP014335	Geobacillus thermoleovorans strain KCTC 3570 chromosome, complete genome	7 crisprs	cas14k,csa3,c2c10_CAS-V-U3,DEDDh,RT,cas3,DinG,WYL,cas14j	0	1	12	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP014336_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014336_1

2748-2978

Orphan

Consensus_repeat	Method
GTTTTTATCTTACCTATGAGGAATTGAAAC	PILER-CR
GTTTTTATCTTACCTATGAGGAATTGAAAC	CRISPRCasFinder
GTTTTTATCTTACCTATGAGGAATTGAAAC	CRT

3 spacers

The CRISPR arrays of NZ_CP014336_1

>merge|NZ_CP014336|1|2748-2978|PILER-CR,CRISPRCasFinder,CRT
GTTTTTATCTTACCTATGAGGAATTGAAACTGTTCGCTTTGGCTCGGACGACAAGACAGGCGGGTTTGTTTTTATCTTACCTATGAGGAATTGAAACGTCATGTCAATCTCCCGGATGCGTTTCCCTGTGCGTACGTTTTTATCTTACCTATGAGGAATTGAAACGCTGATAACATGGAATTGATTAATTCAGTAGTCCATGTTTTTATCTTACCTATGAGGAATTGAAAC

>NZ_CP014336|1|1|2748-2978|PILER-CR
GTTTTTATCTTACCTATGAGGAATTGAAAC	TGTTCGCTTTGGCTCGGACGACAAGACAGGCGGGTTT
GTTTTTATCTTACCTATGAGGAATTGAAAC	GTCATGTCAATCTCCCGGATGCGTTTCCCTGTGCGTAC
GTTTTTATCTTACCTATGAGGAATTGAAAC	GCTGATAACATGGAATTGATTAATTCAGTAGTCCAT
GTTTTTATCTTACCTATGAGGAATTGAAAC

>NZ_CP014336|1|1|2748-2978|CRISPRCasFinder
GTTTTTATCTTACCTATGAGGAATTGAAAC	TGTTCGCTTTGGCTCGGACGACAAGACAGGCGGGTTT
GTTTTTATCTTACCTATGAGGAATTGAAAC	GTCATGTCAATCTCCCGGATGCGTTTCCCTGTGCGTAC
GTTTTTATCTTACCTATGAGGAATTGAAAC	GCTGATAACATGGAATTGATTAATTCAGTAGTCCAT
GTTTTTATCTTACCTATGAGGAATTGAAAC

>NZ_CP014336|1|1|2748-2978|CRT
GTTTTTATCTTACCTATGAGGAATTGAAAC	TGTTCGCTTTGGCTCGGACGACAAGACAGGCGGGTTT
GTTTTTATCTTACCTATGAGGAATTGAAAC	GTCATGTCAATCTCCCGGATGCGTTTCCCTGTGCGTAC
GTTTTTATCTTACCTATGAGGAATTGAAAC	GCTGATAACATGGAATTGATTAATTCAGTAGTCCAT
GTTTTTATCTTACCTATGAGGAATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014336.1\|WP_049752141.1\|4477_4885_-\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NZ_CP014336.1\|WP_020961687.1\|5853_6075_+\|DUF1659-domain-containing-protein	unknown	unknown	gnl\|CDD\|377933
NZ_CP014336.1\|WP_011229515.1\|6536_7007_+\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|350620
NZ_CP014336.1\|WP_062899124.1\|3576_4356_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|224113
NZ_CP014336.1\|WP_011229512.1\|5181_5712_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368849
NZ_CP014336.1\|WP_011229476.1\|8829_9981_+\|replication-initiation-protein	unknown	unknown	gnl\|CDD\|376444
NZ_CP014336.1\|WP_011229514.1\|6370_6517_+\|YvrJ-family-protein	unknown	unknown	gnl\|CDD\|378969
NZ_CP014336.1\|WP_041467679.1\|6093_6306_+\|DUF2922-domain-containing-protein	unknown	unknown	gnl\|CDD\|378571
NZ_CP014336.1\|WP_053532345.1\|7188_7758_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271192
NZ_CP014336.1\|WP_053532343.1\|10991_12311_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP014336.1\|WP_020961687.1\|5853_6075_+\|DUF1659-domain-containing-protein	gnl\|CDD\|377933	pfam07872, DUF1659, Protein of unknown function (DUF1659). This family consists of hypothetical bacterial proteins of unknown function.	1.36319e-07
NZ_CP014336.1\|WP_053532345.1\|7188_7758_+\|site-specific-integrase	gnl\|CDD\|271192	cd01192, INT_C_like_3, Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain. Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.24408e-62
NZ_CP014336.1\|WP_011229515.1\|6536_7007_+\|M15-family-metallopeptidase	gnl\|CDD\|350620	cd14845, L-Ala-D-Glu_peptidase_like, L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase. This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.	2.02094e-61
NZ_CP014336.1\|WP_062899124.1\|3576_4356_-\|ParA-family-protein	gnl\|CDD\|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	2.77154e-46
NZ_CP014336.1\|WP_011229512.1\|5181_5712_+\|hypothetical-protein	gnl\|CDD\|368849	pfam06338, ComK, ComK protein. This family consists of several bacterial ComK proteins. The ComK protein of Bacillus subtilis positively regulates the transcription of several late competence genes as well as comK itself. It has been found that ClpX plays an important role in the regulation of ComK at the post-transcriptional level.	0.00772907
NZ_CP014336.1\|WP_011229476.1\|8829_9981_+\|replication-initiation-protein	gnl\|CDD\|376444	pfam01051, Rep_3, Initiator Replication protein. This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.	9.10497e-70
NZ_CP014336.1\|WP_011229514.1\|6370_6517_+\|YvrJ-family-protein	gnl\|CDD\|378969	pfam12841, YvrJ, YvrJ protein family. This family of short proteins are related to B. subtilis YvrJ protein. None of the members of this family have been functionally characterized.	3.65767e-13
NZ_CP014336.1\|WP_041467679.1\|6093_6306_+\|DUF2922-domain-containing-protein	gnl\|CDD\|378571	pfam11148, DUF2922, Protein of unknown function (DUF2922). This bacterial family of proteins has no known function.	9.10911e-20

>NZ_CP014336.1|WP_062899124.1|3576_4356_-|ParA-family-protein
MGIQKGGCGKSTTTGVLAYLLSRDGYRVLAVDMDSQGNLTELLSRKPSNEFTEKSVLEAMQERDPEPYIVKVNDRLDLLPANNFLATFPRWIYTGETYLGKYIRYKGKPTLILDDTLDKIRHRYDFIVIDTPPSLSEQTTNALCASQYVIMMFECSNWCYSAVPNFMESVEGARVHGRHNTRLLGILRTMNDVRRNDAKAFNEMIEEDYPNEVFKTIITRKAPIGRLSLYGFEENNELNQALEQYENFYKEMMERVQSR
>NZ_CP014336.1|WP_049752141.1|4477_4885_-|ribbon-helix-helix-protein,-CopG-family
MMEGRCYERHDFQVLVLQEFGKRRPRSPEETKRLQEEYLRLLEEIPRMWEEFVEKHKNIYERFGYLDVVVHDDLRVERKKLQRGRPKEEKSKSYRITVRLDDELYELLQKYCQTKNMSESEAVRQLISELKWKRF
>NZ_CP014336.1|WP_011229512.1|5181_5712_+|hypothetical-protein
MDWKEVKRFAYAGQAFIPVNVENRGDSVKLFFRSGETKLLDVQSSLFLKRLLTFFGTSISINRHRYGELVGKKQLVPIVLSYGFTIIPFNVREPVGRQSRVGWFVSREIEQFRQRSPQCTTIHLLSGHQIPVFHSRKFCIDQLKNAKWIEMCYGEIHEPHRRQWINGSAVCETVVM
>NZ_CP014336.1|WP_020961687.1|5853_6075_+|DUF1659-domain-containing-protein
MAASEMVSGRTLVLDFYAGKDSDGKDIIRSQTFRVKSDASVQSLYDAAAAIASLSSGSLRYVRTTLTSHIINA
>NZ_CP014336.1|WP_041467679.1|6093_6306_+|DUF2922-domain-containing-protein
MKTLELTFNAQAGPARILIRYPKEPVDPVQVKTVMNQLVAANVFMTGNGELVSPKSARIIERETQDIQLP
>NZ_CP014336.1|WP_011229514.1|6370_6517_+|YvrJ-family-protein
MDLFSMISEVSFPILVSIYLLYRMETKLDQLTKSIQDLTIALSRGPQN
>NZ_CP014336.1|WP_011229515.1|6536_7007_+|M15-family-metallopeptidase
MELVELLFRAEKRLSGLHPLVADKARALIRKAYEEGIYIIITQGFRTVEEQNRLYALGRTKPGRIVTNARGGYSYHNFGLAFDVCVCNVFKGTLIPSWSLDRRWFRVGQIGKSLGLEWGGDWKSFKDYPHFQYTFGLSLAQLRAGKRPPAAVVAKK
>NZ_CP014336.1|WP_053532345.1|7188_7758_+|site-specific-integrase
MHTVHPIKDREKIEAMKKILRASSLRDELLFTIGINTGLRISDILALRVGDVRNQKGVVERIEIVEKKTKKTRVVALNRKTRRLIELYLAQERPHARGDEPLFRSQKGGRAISRQHAHYILNRAAKAVGIVDRIGTHSLRKTFGYFAYKQGTDLAMIQKILNHSSQAETLRYIGITQEQIDEVTAGLDL
>NZ_CP014336.1|WP_011229476.1|8829_9981_+|replication-initiation-protein
MQTPAVQPQYNSAVTKSNALIEANYKLSTIEQKIILYIISQIRKDDADFKMYKLPIQEFSELLGYRGSPKYTELREITKNLMRKVLEIREGQKLKQLSWVSYVEYDEHSGYVSLAFDPRLKPYLLQLKREFTTYRLKNVMELKSSYSIRMYELLKRWQYMGEVVIRLDDLRMMVGAGDKYSEYHNFKKRVLNPAKKEIAEKTDIMFTYEEIREKRKVAAIRFQIREKVVEPVVVALEEKKEAQADDRYLQFLAVVQAYDRYITEQQFTKIAVLAQKAFGGNWMDELIQTARRIMQRNDIREPIAFLTYFLNEKVQRIQVGIDPNEVTIHSHGGARFVRREIVPDWLRGYEEQLAAESAKSKEVDEDIEQMRRELEERLKKYKD
>NZ_CP014336.1|WP_053532343.1|10991_12311_+|hypothetical-protein
MENLKLENMEISPLDRAKRHVWIQHRGASGWITLAKKEPDGGWRQYHYQPNELAVELPKWLGEDVYFSQNTFYKPQRRIENIRQLRALYVDVDCHTIGYEPEWVVGKLDIEVFYDNILPEPNLIIFSGRGIVCVWLIEPVPYKALPLWKAVENYFYEQLSYVGADKKSLDPTRVFRIDGSVNSKSKREVVVEYRHGDRYVLRDLQYEYLPELTRAETGKKGRKGKLVRLHNIQTLHYARLLDLIRLAELRNYDLKGYRELFCFLYRYWSCCLTDDPDEALRQMIELNAGFKEPLSEKEVIRATKSAEKAWMAKNDAKANEEARKKGYPGAGYNLKNSTIIRWLDITPEEQRHLQTIIDANEKRRRKRERDRARTGELRRGQGAKTREEYLEEQRERTEDKAWQLQKAMERHPDATNKHLAMMLQISVRRVQQLKRLVKN

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Crispr_ID: NZ_CP014336_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014336_2

35506-35736

Orphan

Consensus_repeat	Method
GTTTTTATCTTACCTATGAGGAATTGAAAC	PILER-CR
GTTTTTATCTTACCTATGAGGAATTGAAAC	CRISPRCasFinder
GTTTTTATCTTACCTATGAGGAATTGAAAC	CRT

3 spacers

The CRISPR arrays of NZ_CP014336_2

>merge|NZ_CP014336|2|35506-35736|PILER-CR,CRISPRCasFinder,CRT
GTTTTTATCTTACCTATGAGGAATTGAAACTGTTCGCTTTGGCTCGGACGACAAGACAGGCGGGTTTGTTTTTATCTTACCTATGAGGAATTGAAACGTCATGTCAATCTCCCGGATGCGTTTCCCTGTGCGTACGTTTTTATCTTACCTATGAGGAATTGAAACGCTGATAACATGGAATTGATTAATTCAGTAGTCCATGTTTTTATCTTACCTATGAGGAATTGAAAC

>NZ_CP014336|2|2|35506-35736|PILER-CR
GTTTTTATCTTACCTATGAGGAATTGAAAC	TGTTCGCTTTGGCTCGGACGACAAGACAGGCGGGTTT
GTTTTTATCTTACCTATGAGGAATTGAAAC	GTCATGTCAATCTCCCGGATGCGTTTCCCTGTGCGTAC
GTTTTTATCTTACCTATGAGGAATTGAAAC	GCTGATAACATGGAATTGATTAATTCAGTAGTCCAT
GTTTTTATCTTACCTATGAGGAATTGAAAC

>NZ_CP014336|2|2|35506-35736|CRISPRCasFinder
GTTTTTATCTTACCTATGAGGAATTGAAAC	TGTTCGCTTTGGCTCGGACGACAAGACAGGCGGGTTT
GTTTTTATCTTACCTATGAGGAATTGAAAC	GTCATGTCAATCTCCCGGATGCGTTTCCCTGTGCGTAC
GTTTTTATCTTACCTATGAGGAATTGAAAC	GCTGATAACATGGAATTGATTAATTCAGTAGTCCAT
GTTTTTATCTTACCTATGAGGAATTGAAAC

>NZ_CP014336|2|2|35506-35736|CRT
GTTTTTATCTTACCTATGAGGAATTGAAAC	TGTTCGCTTTGGCTCGGACGACAAGACAGGCGGGTTT
GTTTTTATCTTACCTATGAGGAATTGAAAC	GTCATGTCAATCTCCCGGATGCGTTTCCCTGTGCGTAC
GTTTTTATCTTACCTATGAGGAATTGAAAC	GCTGATAACATGGAATTGATTAATTCAGTAGTCCAT
GTTTTTATCTTACCTATGAGGAATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014336.1\|WP_062899129.1\|20221_21136_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|274042
NZ_CP014336.1\|WP_079935696.1\|18422_19646_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|373913
NZ_CP014336.1\|WP_011230285.1\|23892_25398_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP014336.1\|WP_047752331.1\|28213_29494_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NZ_CP014336.1\|WP_062899127.1\|16993_18364_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|334588
NZ_CP014336.1\|WP_011229509.1\|36068_36356_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014336.1\|WP_011230286.1\|23143_23896_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|181681
NZ_CP014336.1\|WP_011229510.1\|36339_37137_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|224113
NZ_CP014336.1\|WP_011229512.1\|37945_38476_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368849
NZ_CP014336.1\|WP_020961687.1\|38617_38839_+\|DUF1659-domain-containing-protein	unknown	unknown	gnl\|CDD\|377933
NZ_CP014336.1\|WP_011229476.1\|41592_42744_+\|replication-initiation-protein	unknown	unknown	gnl\|CDD\|376444
NZ_CP014336.1\|WP_053532345.1\|39951_40521_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271192
NZ_CP014336.1\|WP_041467679.1\|38857_39070_+\|DUF2922-domain-containing-protein	unknown	unknown	gnl\|CDD\|378571
NZ_CP014336.1\|WP_008881761.1\|29894_30320_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP014336.1\|WP_062898466.1\|30914_32363_+\|IS66-like-element-ISBst12-family-transposase	unknown	unknown	gnl\|CDD\|376980
NZ_CP014336.1\|WP_062899126.1\|16702_16894_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224393
NZ_CP014336.1\|WP_062899130.1\|21532_22564_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225232
NZ_CP014336.1\|WP_049752141.1\|37241_37649_-\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NZ_CP014336.1\|WP_011229515.1\|39300_39771_+\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|350620
NZ_CP014336.1\|WP_011229514.1\|39134_39281_+\|YvrJ-family-protein	unknown	unknown	gnl\|CDD\|378969

Protein	Function_ID	Function_description	E-value
NZ_CP014336.1\|WP_062899129.1\|20221_21136_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|274042	TIGR02224, Tyrosine_recombinase_XerC, tyrosine recombinase XerC. The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerC, one of two closely related chromosomal proteins along with XerD (TIGR02225). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and homologs of XerC on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerC, as some apparent XerC examples score in the gray zone between trusted (450) and noise (410) cutoffs, along with some XerD examples. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair].	8.45391e-53
NZ_CP014336.1\|WP_079935696.1\|18422_19646_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|373913	pfam15515, MvaI_BcnI, MvaI/BcnI restriction endonuclease family. This family of proteins includes the restriction endonucleases MvaI and BcnI. These enzymes both function as monomers. MvaI cleaves the sequence CC/WGG, where W is an A or a T nucleotide, leaving sticky ends. BcnI cleaves the sequence CC/SGG, where S is G or C, leaving sticky ends.	8.59834e-54
NZ_CP014336.1\|WP_011230285.1\|23892_25398_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.46356e-18
NZ_CP014336.1\|WP_047752331.1\|28213_29494_+\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	1.35714e-31
NZ_CP014336.1\|WP_062898466.1\|30914_32363_+\|IS66-like-element-ISBst12-family-transposase	gnl\|CDD\|376980	pfam03050, DDE_Tnp_IS66, Transposase IS66 family. Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.	9.23487e-69
NZ_CP014336.1\|WP_062899127.1\|16993_18364_+\|hypothetical-protein	gnl\|CDD\|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	0.00375434
NZ_CP014336.1\|WP_011230286.1\|23143_23896_-\|ATP-binding-protein	gnl\|CDD\|181681	PRK09183, PRK09183, transposase/IS protein; Provisional.	1.29066e-63
NZ_CP014336.1\|WP_011229510.1\|36339_37137_-\|ParA-family-protein	gnl\|CDD\|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	1.66785e-48
NZ_CP014336.1\|WP_011229512.1\|37945_38476_+\|hypothetical-protein	gnl\|CDD\|368849	pfam06338, ComK, ComK protein. This family consists of several bacterial ComK proteins. The ComK protein of Bacillus subtilis positively regulates the transcription of several late competence genes as well as comK itself. It has been found that ClpX plays an important role in the regulation of ComK at the post-transcriptional level.	0.00772907
NZ_CP014336.1\|WP_020961687.1\|38617_38839_+\|DUF1659-domain-containing-protein	gnl\|CDD\|377933	pfam07872, DUF1659, Protein of unknown function (DUF1659). This family consists of hypothetical bacterial proteins of unknown function.	1.36319e-07
NZ_CP014336.1\|WP_011229476.1\|41592_42744_+\|replication-initiation-protein	gnl\|CDD\|376444	pfam01051, Rep_3, Initiator Replication protein. This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.	9.10497e-70
NZ_CP014336.1\|WP_053532345.1\|39951_40521_+\|site-specific-integrase	gnl\|CDD\|271192	cd01192, INT_C_like_3, Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain. Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.24408e-62
NZ_CP014336.1\|WP_008881761.1\|29894_30320_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.8873e-11
NZ_CP014336.1\|WP_041467679.1\|38857_39070_+\|DUF2922-domain-containing-protein	gnl\|CDD\|378571	pfam11148, DUF2922, Protein of unknown function (DUF2922). This bacterial family of proteins has no known function.	9.10911e-20
NZ_CP014336.1\|WP_062899126.1\|16702_16894_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	6.07451e-12
NZ_CP014336.1\|WP_062899130.1\|21532_22564_-\|hypothetical-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	7.02944e-28
NZ_CP014336.1\|WP_011229515.1\|39300_39771_+\|M15-family-metallopeptidase	gnl\|CDD\|350620	cd14845, L-Ala-D-Glu_peptidase_like, L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase. This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.	2.02094e-61
NZ_CP014336.1\|WP_011229514.1\|39134_39281_+\|YvrJ-family-protein	gnl\|CDD\|378969	pfam12841, YvrJ, YvrJ protein family. This family of short proteins are related to B. subtilis YvrJ protein. None of the members of this family have been functionally characterized.	3.65767e-13

>NZ_CP014336.1|WP_062898466.1|30914_32363_+|IS66-like-element-ISBst12-family-transposase
MLTVQQAVFTVESLIGKVQQQKQLIHQLIQENEHLRHENKQLRKENEQLKYRVQELEARTKKNSSNSHLPPSSDRFEKKRSSREPSGKKPGGQEGHEGKTLRQVEHPHHRVVHRVHTCQGCGASLREVKPFKVDIRQVFDVPPVAIEVTQHEREVKSCPHCRCVQQAEFPSHVTNHVQYGPRLTALVVYLHHIQLIPYKRLSDTIEALYQHSISTGTLANMVKRGREALESNMDIIEDALLESNILHVDETSLRINGKLAWVHVACTSRYTYLAPHASRGKKATDDIGILPRYEGTMMHDAFGTYPKYTHATHALCHAHHLRELKGFIEQGHTWAMRMTTFLLAAKQAVEAHHGALSEEEARRWERVYDRILERAQHRLETMTPLPKKALAFVRRLQKRKEEALRFLREVHVPFDNNQAERDLRMVKVKENISGTFREETFAQSFCIARSIVSTLTKHEKNVWDSLCLLLAGETIDRVLSAT
>NZ_CP014336.1|WP_008881761.1|29894_30320_+|GNAT-family-N-acetyltransferase
MEHITIAKLNELDEIVRIDAEVIGDESRRTYIKKAIEEGCCLVAKVNRSIVGFLVYNTHFFECSFISLVVVKPSERRKGYAKSLIKYFENISPTEKIFSSTNQSNERMHRVFLSLGYSKSGFIDNLDEGDPEIIYFKQLKK
>NZ_CP014336.1|WP_047752331.1|28213_29494_+|IS110-family-transposase
MNCTQNYKIDQVTEQTLVVGIDIAKRTHYACFVDDRGRVLRKSFPIFQSKEGFQQLYKAIQGAMQAFGKSEVIVAVEPTGHYWLNLAYFLEEHGIPLVMVNPAHVCRSKELDDNLPTKHDAKDALVIARLAKDGRFLVPRLLHEIEADLRVGSTLKEKLRKEQTAVKNAIVRWTDRYFPEFWTVFRDLGKTALSVLEWTPLPADMAGRTVEELLEVYRQSEGMKCPQKAKIQALINTAKDSIGVTEGTAMARFEIAALVRRYRQLEAEIAALDAELKALVQTTMEYQWLKTVDGLGDATIIDLLAEIGSFAHYRDPRQLVKLAGLTLKENSSGQRKGQKHISKRGRKRLRSVLFRAVIPLIRHNEAFRELHEYYTTRPVNPLTGKQSIVALCRKLLNVLFAICTKKQAFDAERMKQDVLSQVQRAA
>NZ_CP014336.1|WP_011230285.1|23892_25398_-|IS21-family-transposase
MLAMPEINRIRKLREKKGLSIAEISRETGYNWRTVKKYADGDISVQPTIKRKKGMMEEEGYGQIIDDWLEEDAKLPRKQRRTNKTMFEALCRDHGFQGSYRTVCAYVQKRRPQLKLEKEQRYERLEHPPGEAQVDFGKMTVVTKEGKEEERSVLIMSFPYSNAAFAYPLPAENSECFLHGLTQLFRQAGGVPKALRIDNLSAAIVSIRKGGERRFTEAFEKFQLYYRFDVQVCNPYSGHEKGNAERKVYYTRNLCFIPAPLMESDPELVEWLHRKMVEDRNRPHYEKGRWIEELWQEEQPELLALPEQDLPIFSLDHAYVNKYGEVMVDGKAFVVHGLSVPNRVLVKKEWNRFVVFSSDGDVHLEAPRPYTNVKREIPWKEIFAEWETKPRVVGHSRYRTYLPEAIRTYLAGPPPQVVARLKGLRALLDRHTLYEIAQWLEESQRWDLAPHEIGVLMEAKHSYYPDKWEESYTPSVLIDYETDLTVYDQRLHPAREGGVQR
>NZ_CP014336.1|WP_011230286.1|23143_23896_-|ATP-binding-protein
MRAEVKEICKALHLAYIADRFEEVRFETKEQFLRDVLALELSCRQEAKQARLIKKAKFRELKWLKDYEWSGHIHWPATTSREELCDLRFLERKQNVLLLGSPGTGKTHLATALGIQACQQGHEVRFFRVADLVAQLEEALKNGTLGRLKRSLDPCELLILDELGYVPFQKQGSELLFHIIADCYERKSVMVTSNLEFGQWNRVFGDNRLTAALVDRLVHHAHILAFTGESYRLRNALSAIQPSSASGLEP
>NZ_CP014336.1|WP_062899130.1|21532_22564_-|hypothetical-protein
MSLIENQDEFFKVYNINKEEFESASLNWSVLKEIYYDYLKKYPDFQSIANPIADLLRQDSNVHSVRSRIKNAEHLVEKIIRKTIKKRNNGDTSYEINPDNYQKEITDIIGIRVLHLYKDQAKEIDKLIRDKWELAEQPIIYYREGDSLENIDTKKFDTKKHPAGYRSWHYLIKTQPTKTENLVEIQVRTIFEEGWSEIDHQLRYPYELNNKLLNEQLLVLNRLAGSADEMVNTIRETHKSFRAITEENKKKDNLIEGLRKEIEILSEKYNIQKQEMKSIENKLKDLEKAQQHSSNFSLIGNIDIPSSIQIGGNIDIPSSFQISDLSSISFPIGDSAIPYRLKK
>NZ_CP014336.1|WP_062899129.1|20221_21136_-|tyrosine-type-recombinase/integrase
MLHEYETYLQEKGFSPNTVISYLNDVNQFLKDLHLRPGDYVTSADIRKWIQQMLNPVEGKPLAISTINRRLNSLRSFYAWAVEHYKLEQNPMKDIQDLKSADEENEKIMWLTEEEFEDLLHRMRKKPVQSRGVDPEEKYRRDRAVVYLLTYAGLRVEELSNLKLTDLDLEMKRIRIVGKGMKVRTVPISNILLAELEDWLKFRAEMAKKKPHVAESPYVFYSQRSPKFSVRGIQRMIESYSLPNKKLTPHMFRHTFCKWMLKATNNDIEKVRRLAGHSNIATTSRYLKDSYSDLADAVEALPKF
>NZ_CP014336.1|WP_079935696.1|18422_19646_-|helix-turn-helix-domain-containing-protein
MDKELKNYMDSLISILYETNLTATEIAKRSGLSTSQISRILSGKCLPRFSSLCKIFSSLNIDIRLFFKNPNWSYSELLNDKISLMTDDEIKKLRCLLSQNIRLIQYNKKRLNPHFTQSHLSKLIGGDGSTKSLERILRGKHDLSFEKLIAISIALNVNPAKLLTDTRSDYNMMDIKTFIKKLEEIKAKGYIRTLRRGDTGVGHTLEQELGLTENNISLPDLGVAELKAARRNTSSMLTLFTKEPLSDKGRKRDRYLLETFAYDSDKEDRIKELYTTISALDYNAQGFKLEVTNKEIRLIHKDIPLDVYWTAELLQKTFEDKLPALVYVYADHIGEDADEHFHYTEARLLKGFDFKGFMKAVQDGYIKVDLRMHMKNNGRPRNHGTAFRILRSHLPICFKEQQILVKP
>NZ_CP014336.1|WP_062899127.1|16993_18364_+|hypothetical-protein
MKVMNTGNMLENRDEAIRQIFLNILEQDEDFWDFRNENTKEFSHGYHSYPAMMIPQVARNLMRMILSNQPNIKSVFDPFMGSGTTLVEGVLHGLDSFGTDLNPLARLLGKVKTTPLNPTYLSEVAEQFIFSLSNDELSYKNGDLVLEKPEFKNIDYWFKPYVIDYLQIIKNNIKKIQHDDIKLFFWAVFSEVVRYVSNTRNSEFKLYRMDEEKLADWNPNVFDVFIKFLNRNIELNQQFYELYNEQNPTNQPAVKIFDLNAMNLEGIDDNSFDLLITSPPYGDSRTTVAYGQFSRLSLQWLDFNEIGEDESLVKDINKIDALLLGGKVDKELKNSLASETLERTIESIAIEDEKRAKEVLQFYIDLDKALKEIARVMKPNSYQCWVVGNRTVKKVKIPTHQIIIELFQKYGVRHVLTFERNIPNKKMPKENSPTNKVGEKFTTMNGEVIFILRKEG
>NZ_CP014336.1|WP_062899126.1|16702_16894_+|helix-turn-helix-domain-containing-protein
MKCQLKLILDEIGMTQKQLAEKVNVSTPTISSIAKNQSIPRLDLAFRISKAVGRKIEEIWIYE
>NZ_CP014336.1|WP_011229509.1|36068_36356_-|hypothetical-protein
MSKVDDIKNMKRQQKVITPTQVLTDPVGEENNTVLNEDDNQPRKEGKKVERKRVSFDIRTDLHKELKMQSILQEKNIYLLIEEALEKYLNELKNN
>NZ_CP014336.1|WP_011229510.1|36339_37137_-|ParA-family-protein
MAITITMGIQKGGCGKSTTTGVLAYLLSRDGYRVLAVDMDSQGNLTELLSRKPSNEFTEKSVLEAMQERDPEPYIVKVNDRLDLLPANNFLATFPRWIYTGETYLGKYIRYKGKPTLILDDTLDKIRHRYDFIVIDTPPSLSEQTTNALCASQYVIMMFECSNWCYSAVPNFMESVEGARVHGRHNTRLLGILRTMNDVRRNDAKAFNEMIEEDYPNEVFKTIITRKAPIGRLSLYGFEENNELNQALEQYENFYKEMMERVQSR
>NZ_CP014336.1|WP_049752141.1|37241_37649_-|ribbon-helix-helix-protein,-CopG-family
MMEGRCYERHDFQVLVLQEFGKRRPRSPEETKRLQEEYLRLLEEIPRMWEEFVEKHKNIYERFGYLDVVVHDDLRVERKKLQRGRPKEEKSKSYRITVRLDDELYELLQKYCQTKNMSESEAVRQLISELKWKRF
>NZ_CP014336.1|WP_011229512.1|37945_38476_+|hypothetical-protein
MDWKEVKRFAYAGQAFIPVNVENRGDSVKLFFRSGETKLLDVQSSLFLKRLLTFFGTSISINRHRYGELVGKKQLVPIVLSYGFTIIPFNVREPVGRQSRVGWFVSREIEQFRQRSPQCTTIHLLSGHQIPVFHSRKFCIDQLKNAKWIEMCYGEIHEPHRRQWINGSAVCETVVM
>NZ_CP014336.1|WP_020961687.1|38617_38839_+|DUF1659-domain-containing-protein
MAASEMVSGRTLVLDFYAGKDSDGKDIIRSQTFRVKSDASVQSLYDAAAAIASLSSGSLRYVRTTLTSHIINA
>NZ_CP014336.1|WP_041467679.1|38857_39070_+|DUF2922-domain-containing-protein
MKTLELTFNAQAGPARILIRYPKEPVDPVQVKTVMNQLVAANVFMTGNGELVSPKSARIIERETQDIQLP
>NZ_CP014336.1|WP_011229514.1|39134_39281_+|YvrJ-family-protein
MDLFSMISEVSFPILVSIYLLYRMETKLDQLTKSIQDLTIALSRGPQN
>NZ_CP014336.1|WP_011229515.1|39300_39771_+|M15-family-metallopeptidase
MELVELLFRAEKRLSGLHPLVADKARALIRKAYEEGIYIIITQGFRTVEEQNRLYALGRTKPGRIVTNARGGYSYHNFGLAFDVCVCNVFKGTLIPSWSLDRRWFRVGQIGKSLGLEWGGDWKSFKDYPHFQYTFGLSLAQLRAGKRPPAAVVAKK
>NZ_CP014336.1|WP_053532345.1|39951_40521_+|site-specific-integrase
MHTVHPIKDREKIEAMKKILRASSLRDELLFTIGINTGLRISDILALRVGDVRNQKGVVERIEIVEKKTKKTRVVALNRKTRRLIELYLAQERPHARGDEPLFRSQKGGRAISRQHAHYILNRAAKAVGIVDRIGTHSLRKTFGYFAYKQGTDLAMIQKILNHSSQAETLRYIGITQEQIDEVTAGLDL
>NZ_CP014336.1|WP_011229476.1|41592_42744_+|replication-initiation-protein
MQTPAVQPQYNSAVTKSNALIEANYKLSTIEQKIILYIISQIRKDDADFKMYKLPIQEFSELLGYRGSPKYTELREITKNLMRKVLEIREGQKLKQLSWVSYVEYDEHSGYVSLAFDPRLKPYLLQLKREFTTYRLKNVMELKSSYSIRMYELLKRWQYMGEVVIRLDDLRMMVGAGDKYSEYHNFKKRVLNPAKKEIAEKTDIMFTYEEIREKRKVAAIRFQIREKVVEPVVVALEEKKEAQADDRYLQFLAVVQAYDRYITEQQFTKIAVLAQKAFGGNWMDELIQTARRIMQRNDIREPIAFLTYFLNEKVQRIQVGIDPNEVTIHSHGGARFVRREIVPDWLRGYEEQLAAESAKSKEVDEDIEQMRRELEERLKKYKD

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Identity
NZ_CP014336_1	1.1\|2778\|37\|NZ_CP014336\|PILER-CR,CRISPRCasFinder,CRT	2778-2814	37	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	2778-2814	1.0
NZ_CP014336_1	1.1\|2778\|37\|NZ_CP014336\|PILER-CR,CRISPRCasFinder,CRT	2778-2814	37	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	35536-35572	1.0
NZ_CP014336_1	1.2\|2845\|38\|NZ_CP014336\|PILER-CR,CRISPRCasFinder,CRT	2845-2882	38	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	2845-2882	1.0
NZ_CP014336_1	1.2\|2845\|38\|NZ_CP014336\|PILER-CR,CRISPRCasFinder,CRT	2845-2882	38	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	35603-35640	1.0
NZ_CP014336_1	1.3\|2913\|36\|NZ_CP014336\|PILER-CR,CRISPRCasFinder,CRT	2913-2948	36	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	2913-2948	1.0
NZ_CP014336_1	1.3\|2913\|36\|NZ_CP014336\|PILER-CR,CRISPRCasFinder,CRT	2913-2948	36	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	35671-35706	1.0
NZ_CP014336_2	2.1\|35536\|37\|NZ_CP014336\|PILER-CR,CRISPRCasFinder,CRT	35536-35572	37	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	2778-2814	1.0
NZ_CP014336_2	2.1\|35536\|37\|NZ_CP014336\|PILER-CR,CRISPRCasFinder,CRT	35536-35572	37	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	35536-35572	1.0
NZ_CP014336_2	2.2\|35603\|38\|NZ_CP014336\|PILER-CR,CRISPRCasFinder,CRT	35603-35640	38	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	2845-2882	1.0
NZ_CP014336_2	2.2\|35603\|38\|NZ_CP014336\|PILER-CR,CRISPRCasFinder,CRT	35603-35640	38	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	35603-35640	1.0
NZ_CP014336_2	2.3\|35671\|36\|NZ_CP014336\|PILER-CR,CRISPRCasFinder,CRT	35671-35706	36	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	2913-2948	1.0
NZ_CP014336_2	2.3\|35671\|36\|NZ_CP014336\|PILER-CR,CRISPRCasFinder,CRT	35671-35706	36	NZ_CP014336	Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence	35671-35706	1.0

1. spacer 1.1|2778|37|NZ_CP014336|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 0, identity: 1.0

tgttcgctttggctcggacgacaagacaggcgggttt	CRISPR spacer
tgttcgctttggctcggacgacaagacaggcgggttt	Protospacer
*************************************

2. spacer 1.1|2778|37|NZ_CP014336|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 0, identity: 1.0

tgttcgctttggctcggacgacaagacaggcgggttt	CRISPR spacer
tgttcgctttggctcggacgacaagacaggcgggttt	Protospacer
*************************************

3. spacer 1.2|2845|38|NZ_CP014336|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 0, identity: 1.0

gtcatgtcaatctcccggatgcgtttccctgtgcgtac	CRISPR spacer
gtcatgtcaatctcccggatgcgtttccctgtgcgtac	Protospacer
**************************************

4. spacer 1.2|2845|38|NZ_CP014336|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 0, identity: 1.0

gtcatgtcaatctcccggatgcgtttccctgtgcgtac	CRISPR spacer
gtcatgtcaatctcccggatgcgtttccctgtgcgtac	Protospacer
**************************************

5. spacer 1.3|2913|36|NZ_CP014336|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 0, identity: 1.0

gctgataacatggaattgattaattcagtagtccat	CRISPR spacer
gctgataacatggaattgattaattcagtagtccat	Protospacer
************************************

6. spacer 1.3|2913|36|NZ_CP014336|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 0, identity: 1.0

gctgataacatggaattgattaattcagtagtccat	CRISPR spacer
gctgataacatggaattgattaattcagtagtccat	Protospacer
************************************

7. spacer 2.1|35536|37|NZ_CP014336|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 0, identity: 1.0

tgttcgctttggctcggacgacaagacaggcgggttt	CRISPR spacer
tgttcgctttggctcggacgacaagacaggcgggttt	Protospacer
*************************************

8. spacer 2.1|35536|37|NZ_CP014336|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 0, identity: 1.0

tgttcgctttggctcggacgacaagacaggcgggttt	CRISPR spacer
tgttcgctttggctcggacgacaagacaggcgggttt	Protospacer
*************************************

9. spacer 2.2|35603|38|NZ_CP014336|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 0, identity: 1.0

gtcatgtcaatctcccggatgcgtttccctgtgcgtac	CRISPR spacer
gtcatgtcaatctcccggatgcgtttccctgtgcgtac	Protospacer
**************************************

10. spacer 2.2|35603|38|NZ_CP014336|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 0, identity: 1.0

gtcatgtcaatctcccggatgcgtttccctgtgcgtac	CRISPR spacer
gtcatgtcaatctcccggatgcgtttccctgtgcgtac	Protospacer
**************************************

11. spacer 2.3|35671|36|NZ_CP014336|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 0, identity: 1.0

gctgataacatggaattgattaattcagtagtccat	CRISPR spacer
gctgataacatggaattgattaattcagtagtccat	Protospacer
************************************

12. spacer 2.3|35671|36|NZ_CP014336|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014336 (Geobacillus thermoleovorans strain KCTC 3570 plasmid pLDW-1, complete sequence) position: , mismatch: 0, identity: 1.0

gctgataacatggaattgattaattcagtagtccat	CRISPR spacer
gctgataacatggaattgattaattcagtagtccat	Protospacer
************************************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP014335

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP014335_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014335_1

298915-299150

Orphan

Consensus_repeat	Method
GGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATT	CRT
GGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATT	PILER-CR

3 spacers

The CRISPR arrays of NZ_CP014335_1

>merge|NZ_CP014335|1|298915-299150|CRT,PILER-CR
TGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATTTGGAAGTAACCGACATCGGCTACGACAAGGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATTTTGAGATTCTACTGCGATGCGCAACTTTGGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATTGGACGTATGGCAAGACCTGGACTTGCACGGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAACT

>NZ_CP014335|1|1|298915-299150|CRT
TGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATT	TGGAAGTAACCGACATCGGCTACGACAA
GGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATT	TTGAGATTCTACTGCGATGCGCAACTTT
GGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATT	GGACGTATGGCAAGACCTGGACTTGCAC
GGTCATAGTTCCCCTGAGATTATCGCTGTGGTATAACT

>NZ_CP014335|1|1|298916-299150|PILER-CR
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATTT	GGAAGTAACCGACATCGGCTACGACAAG
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATTT	TGAGATTCTACTGCGATGCGCAACTTTG
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAATTG	GACGTATGGCAAGACCTGGACTTGCACG
GTCATAGTTCCCCTGAGATTATCGCTGTGGTATAACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014335.1\|WP_011229819.1\|286848_287976_-\|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213262
NZ_CP014335.1\|WP_062898340.1\|307034_308168_-\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NZ_CP014335.1\|WP_082816465.1\|298216_298582_+\|transposase	unknown	unknown	gnl\|CDD\|273806
NZ_CP014335.1\|WP_062898336.1\|296928_298149_+\|TIGR02679-family-protein	unknown	unknown	gnl\|CDD\|274255
NZ_CP014335.1\|WP_014194801.1\|289369_290017_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NZ_CP014335.1\|WP_062898337.1\|299276_300935_-\|IS1634-family-transposase	unknown	unknown	gnl\|CDD\|379471
NZ_CP014335.1\|WP_062898334.1\|291654_292851_+\|TIGR02678-family-protein	unknown	unknown	gnl\|CDD\|274254
NZ_CP014335.1\|WP_062898338.1\|301258_302059_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|225806
NZ_CP014335.1\|WP_011229674.1\|303449_304013_-\|transposase	unknown	unknown	unknown
NZ_CP014335.1\|WP_015374208.1\|302051_303299_-\|IS481-family-transposase	unknown	unknown	gnl\|CDD\|366234
NZ_CP014335.1\|WP_011229827.1\|312731_312956_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_062898335.1\|292810_296932_+\|TIGR02680-family-protein	unknown	unknown	gnl\|CDD\|274256
NZ_CP014335.1\|WP_031206583.1\|287992_288895_-\|glycine/betaine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270246
NZ_CP014335.1\|WP_062898333.1\|290161_291652_+\|TIGR02677-family-protein	unknown	unknown	gnl\|CDD\|131724
NZ_CP014335.1\|WP_062898341.1\|313092_314148_+\|P1-family-peptidase	unknown	unknown	gnl\|CDD\|239071
NZ_CP014335.1\|WP_062898339.1\|306251_306887_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_082816466.1\|311420_311816_+\|transposase	unknown	unknown	gnl\|CDD\|273806
NZ_CP014335.1\|WP_011229818.1\|285964_286594_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NZ_CP014335.1\|WP_023633356.1\|284435_285740_+\|homocysteine-synthase	unknown	unknown	gnl\|CDD\|236201
NZ_CP014335.1\|WP_062899080.1\|305728_306262_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|213752

Protein	Function_ID	Function_description	E-value
NZ_CP014335.1\|WP_011229819.1\|286848_287976_-\|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213262	cd03295, ABC_OpuCA_Osmoprotection, ATP-binding cassette domain of the osmoprotectant transporter. OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.63752e-163
NZ_CP014335.1\|WP_082816465.1\|298216_298582_+\|transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	1.32727e-06
NZ_CP014335.1\|WP_062898336.1\|296928_298149_+\|TIGR02679-family-protein	gnl\|CDD\|274255	TIGR02679, conserved_hypothetical_protein, TIGR02679 family protein. Members of this protein belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). [Hypothetical proteins, Conserved].	2.5046e-134
NZ_CP014335.1\|WP_014194801.1\|289369_290017_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.1407e-09
NZ_CP014335.1\|WP_062898337.1\|299276_300935_-\|IS1634-family-transposase	gnl\|CDD\|379471	pfam14104, DUF4277, Domain of unknown function (DUF4277). This presumed domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is approximately 110 amino acids in length. There is a conserved NGLGF sequence motif.	9.71941e-32
NZ_CP014335.1\|WP_062898334.1\|291654_292851_+\|TIGR02678-family-protein	gnl\|CDD\|274254	TIGR02678, hypothetical_protein, TIGR02678 family protein. Members of this protein belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). [Hypothetical proteins, Conserved].	2.93738e-160
NZ_CP014335.1\|WP_062898338.1\|301258_302059_-\|AAA-family-ATPase	gnl\|CDD\|225806	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion].	2.6389e-38
NZ_CP014335.1\|WP_015374208.1\|302051_303299_-\|IS481-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	7.89716e-22
NZ_CP014335.1\|WP_062898335.1\|292810_296932_+\|TIGR02680-family-protein	gnl\|CDD\|274256	TIGR02680, conserved_hypothetical_protein, TIGR02680 family protein. Members of this protein family belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). Proteins in this family average over 1400 amino acids in length. [Hypothetical proteins, Conserved].	0
NZ_CP014335.1\|WP_031206583.1\|287992_288895_-\|glycine/betaine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270246	cd13528, PBP2_osmoprotectants, Substrate-binding domain of osmoregulatory ABC-type transporters; the type 2 periplasmic-binding protein fold. This family represents the periplasmic substrate-binding component of ABC transport systems that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, bacteria and archaea accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	7.02581e-143
NZ_CP014335.1\|WP_062898333.1\|290161_291652_+\|TIGR02677-family-protein	gnl\|CDD\|131724	TIGR02677, conserved_hypothetical_protein, TIGR02677 family protein. Members of this protein belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). [Hypothetical proteins, Conserved].	0
NZ_CP014335.1\|WP_062898341.1\|313092_314148_+\|P1-family-peptidase	gnl\|CDD\|239071	cd02253, DmpA, L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active heterodimeric form. The cleavage results in two polypeptide chains, with one chain containing an N-terminal nucleophile. This group represents one of the rare aminopeptidases that are not metalloenzymes. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.64573e-174
NZ_CP014335.1\|WP_062898340.1\|307034_308168_-\|IS4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	1.35958e-25
NZ_CP014335.1\|WP_082816466.1\|311420_311816_+\|transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	5.55379e-05
NZ_CP014335.1\|WP_011229818.1\|285964_286594_-\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	2.60548e-80
NZ_CP014335.1\|WP_023633356.1\|284435_285740_+\|homocysteine-synthase	gnl\|CDD\|236201	PRK08248, PRK08248, homocysteine synthase.	0
NZ_CP014335.1\|WP_062899080.1\|305728_306262_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|213752	TIGR02954, RNA_polymerase_ECF-type_sigma_factor, RNA polymerase sigma-70 factor, TIGR02954 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family. This family is found in certain Bacillus and Clostridium species.	1.80608e-44

>NZ_CP014335.1|WP_082816465.1|298216_298582_+|transposase
MLVRLELDEAKQRLLFGFFETYLRLSEEEEAKPRHEVSQMETKEAKRVMELIVSYEQRGLEKGIQQGIEQGLKQGMKQGRQEGIEEGKLDVVKRMLAKGYDVDTIHELTGLPMEKIERMKG
>NZ_CP014335.1|WP_062898336.1|296928_298149_+|TIGR02679-family-protein
MSTVKEAAAFFRSERAFHRLFVEMKRKYESLGRVGGTVSLQSFSDEEREAIAAFFGKDVSRVSLIAFEKQLGQTRFAGVGLVELLEQYFGAPLVSNKERRQAEEEERDRFFARLTEEHHWVESVRPQRFVQTAYETDRRSLEEAIRLVSAALGRLPLPSYMRLPLFAQQVAGDPHAFDLSTLPGRLLLSALQATVPGDWDMASVESVNELLQSVGLLREDILNFVTCANILAETKDGPHPVFSAAWEANTALNMPLRDVLSLVRARPAHGGTVYIVENAGVFSTLLDTRAPLVSTNGQMNLATMKLLDLLASSGAKLYYSGDFDPEGLAMAERLQERYGQAVTLWRFSVEDYRAANPVVDLTPERLAKLASVTSTPLQPLKEEMAETKKAGYQEAIIGRLTEDING
>NZ_CP014335.1|WP_062898335.1|292810_296932_+|TIGR02680-family-protein
MANPWVLHRAGLINFWYYDEQYFHFADGKLLLRGSNGAGKSVTMQSLIPVLLDGKKTPDRLDPFGSRARRMEDYLLGEKDVVNRDERTGYLFLEYKRKESDQYVTTGIGLRAKRQKSLDFWGFVLFDNRRIGYDLQLYKQEKTGEKIPLTKRELATALGAGGTVVETQKDYMELVNKHVFRFESLEAFQELIELLIQLRSPKLSKDFKPTVIYEILESSLPPLTDDELRHLSDTIENMDQAKQQLEQLERDERALKRLCDQYRLYNEYMIAEKATEYVKAVKQAEQLAAAQHRLHDEEEQARKTLDELDESITRLRREEDVLRSREIDLAGHEVFQQAEKYEQLKSERERLQERWERHEQTIAEKERLERQHRRRLDESEARLDDLERKLEDELAQLRADAEEGAFSLHETNEDDFHRHRQKQQEFSFAAWKQEADRHIEQLEELARLWRRHDEVKQRYEEASSEAGERQREMDEWRHQQRKWEELLEQEKERFEQAVLAWIGQGDVDISEADIQSFLQQMDALYEQYSLDDLKRPFVQAYYDAVGKKKDEKWRLEHDIRLLEEKRAEREAELRRWREQRDPEPERDEQTTAARLALEEKGIPFVPLYAAVEFVDDVPDDVRERIESALSHAGLLDALITAREIDVACDRVLIPKPVHMAHTLADYLRPDANAPVSMERIDEVLRSIVITDADQEGGMTIDETGRYSLGLVRGHAPRGSKAAFIGRAARERWRLENIAALEAEIAAMGQEIDRLRGAHEDVEAAIQALADWLASFPADRDVRTAFDEAQEARRQAESKEREWKRQEEKAALLAREWKQIKQQLRDESAELDLAFTLDGCEQAMLAMKSYVRHLHELEVLYRETRHTEAVIAQQREQLAVLEAEIDEAKGERNRLRDETERLALRIAEMERTLAQMGADDIRAEIARIQERLAFLRREIPRLVNERARTEQRLMRLVEEREKGAQREAFARELAAMWEKSFAREAALGLVDLDRSRSLLEQAKEAKQRYEAVLKETRSSLLARLNTVFFQESSNLTEYRASFEPLEEQTKPEWTAAAPDDEMAMKAADWREKQERHVIYLDYKGERATPFAVLAEVERDIVLQHEYMKEQDRELYEDVILKSVGRILRSRIQRAERWVNDMNKLMGGLDTSSGLVLSIQWKPKTAETEAELDTKELVRLLRLDPRLLREEDLQRVTNHFRSKIARARELLEERGQGSTLHQIIKEVLDYRKWFSFTLYYEKTNEPKRELTNHRFYQFSGGEKAMAMYIPLFAAAYSRYQEAGDDAPYIISLDEAFAGVDENNIRNMFGLVEQLGFNYIMNSQALWGDYDTVPALSICELVRPRNASFVTVIHYRWNGRVKQLMVDDKEWEMIKT
>NZ_CP014335.1|WP_062898334.1|291654_292851_+|TIGR02678-family-protein
METAFDDKAKEALAALFEQFWIIRDKEPDLYQLVREREHVLKKYVEEKFGYRLIVHRYFAKLEKIPAEPEPWMGIESFQEPLDYALFCCLMAYLEGKAVEEKFLLSDVCEEIRAMYPGDLPVDWTNYSHRRALIRVLKTAEQIGLVRRMDGEIEAFAQHVEEEALYEVPVLARYFMRTYPKDLLQYESIDELLAEEWKASPQDYRRHRLYRKLFLSPAVHRTEGDEQDFYYLRNFRHRLRDDIEAHTPFRYELYKNAAMLTLPERQAPYTVFPDQKGTSEVILHFAALVRERLGEYPPDEYGRIRLTPEQFSAWLADCRRRYGAGWGKTYRDMSAAELVRVVLAALNEWRMADVEHDTGMIVLYPLLGRMSGRYPDDFDAKEGGEHGESMGASSCGAD
>NZ_CP014335.1|WP_062898333.1|290161_291652_+|TIGR02677-family-protein
MDATWLKPIVETKYLSTENAHRYRAILRYFYIQHERMRQYLFPEEVYAFLKQHEEFADYTEEELQQDLDQLVKWNNLIARQETSHVRTIEEFKKKRFRYQCSPYTVEIERMIRTLEQLGDSFGGSLERTRFDRLYASLSRMETIIASDFQEQPDEMHQVWEETFDYFKKIIQNSADYIAYLHGENLEERMTSESFLVYKEQFTAYLRDFIVALQKTSIQIEQLLEDLPEDGVRQFIEHVVDYERSIPRFADALPPRAVQIEEKWETWRSLCEWFLGRDGHESELSFLQYQTNEAIRRLTRVVQRLGERHHHFRSRKGDYLHLARWFSRLESIEEAHCLSAVVFGCFHTKHLVADFGATDNIYRDVWDEPPAEWVTKPRVRHYGEKKKPQAIEDKEREKEEARLRYLEEKAREEAELKQFVTDGKIVLADLPEVTPYVRKTLLGWIAKAMGREGQAMKTENGWVVNVVNKEGTICLRAEDGELVMPNYEIHVLSRGE
>NZ_CP014335.1|WP_014194801.1|289369_290017_-|hypothetical-protein
MEALLREILHEVKATRTAVESLEQRVGALEGQVANLNERTGALEVLAANLNERTGALEAQMAQLNERTSALEQQFTQLNERTSNLEHQVAQLSERMGTVEHQVAQLNERMGTVEHQVAQLNEQTNTLARRIDLLDERTNETKAIVEALRHGQEVLTAKYEAMAHDLHHMKGDLTRITSILEDKVLPALAEHEAGLSVLNARVFKTESALHRLVYA
>NZ_CP014335.1|WP_031206583.1|287992_288895_-|glycine/betaine-ABC-transporter-substrate-binding-protein
MLRKWMMILLAVGLVFGLAACSGTSDAKGKIVISGKKFTEQVILTHLLAEYVKANTDLDVEVKDSLGGAFMLQQAIENGDVDMYVEYTGTGYLNILKQPYDPKKTPEQIYNETKKLYKEKYNIAWLKPLGFNNTYALAMRRDLAEKLGVKTYSDLAKHSSSLTFGSDAEFFERSDGYDGLVDTYGFQFKKKVTIDPDLQYEAAKNGEIDVITAYTTDARIKKYDLVVLKDDKQYFPPYHAVPIIRQEVLDANPDLEEKLNKLANILTDEKMMELNGEVNLEGKRPREVAIDFLKAEGLID
>NZ_CP014335.1|WP_011229819.1|286848_287976_-|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein
MIRFENVTKQYEDGFVALKNINLEIRKGELVALIGPSGCGKTTTMRMINRLIEPTSGKVYIDGQDISQLDPVELRRNIGYVIQQIGLFPHMTIAENIALVPKLKKWEKHAYEKRVDELLELVGLDPATFKHRYPSELSGGQQQRVGVVRALAAEPDIILMDEPFSALDPISREQLQDDIVRLQEEIHKTIVFVTHDMDEAIKIADRIALMKDGEIVQFATPDQMLRRPANSFVREFIGEDRLRIRHTAVPTAEDLMSADVATISPRRGLAEAFRLMKAKKVDSLVVVDKKQVFLGIVTLKQIEQRYQEEHLLVADIADYDVTTLSKEADVTNVAALFQDPDVRIIPVLDGDRLVGGITRSSMMRALAEWTFQQHA
>NZ_CP014335.1|WP_011229818.1|285964_286594_-|ABC-transporter-permease
MELLQTFIERKNDIWIAFQEHVLLSAIAMSIAIVIAVPLGVVLTRYRKLAEPIIGIAAIIQTIPSLALLGFMLPIFGIGKLPAIIALTLYALLPILRNTYTGILGVDPTLVDAGRGMGMTSRQILWMVELPLSLPVIMAGVRTATVLTIGVAALATFIGAGGLGDLIDRGLRIADKNLILAGAIPAAMLAIVFDWLLRKVEKKVTPKGL
>NZ_CP014335.1|WP_023633356.1|284435_285740_+|homocysteine-synthase
MSNEQTFRPETLAIHAGQKPDAETGARAVPIYQTSSYVFRDSEHAANLFGLKEEGFIYTRIMNPTNDVLEKRIAALEGGIGALALSSGQAAVFYSIINIASAGDEIVSSSSIYGGTYNLFAHTLRKFGITVKFVDPSDPENFERAITDKTKALFAETIGNPKNDVLDIEAVADIAHRHAIPLIVDNTVASPYLLRPIEFGADIVVHSATKFIGGHGNSIGGVIVDSGKFDWKGSGKFPEFTEPDPSYHGLVYVDAVGEAAYITKARIQLLRDLGAALSPFNAFLLLQGLETLHLRMQRHSENALAVAKFLEEEEAVESVSYPGLPSHPSHELAKKYLPNGQGAIVTFEIKGGVEAGKKLIDSVKLFSHLANIGDSKSLIIHPASTTHEQLTPEEQLSAGVTPGLVRLSVGTEAIDDILDDLRQAIRQSQTVGVK
>NZ_CP014335.1|WP_062898337.1|299276_300935_-|IS1634-family-transposase
MNVQVKKVYRNSYLNIISALFKKLGLPQLIDHLVPVDPQCQTRVSDAVQAILYNVFDGRQALVHLEHWAQEVDCEKLIRPDLHPSWLNDDALARHLDRLYEAGIHNVISTCLIHIYRKEGLSLRAFHADTTDKTVYGAYESASLEALQITHGYNRHHRWQKQIGFGLVGNEDGIPFYDDVHDGNLPDKTWNPEVLSRVHEQLKQAKIEDEWIYVADSAAMTKETLAQTKAANAFLITRGPSSLRIVKTALAEADAEDTTWSDPFTLAERNGATYRVWETASTYEGHPVRLIVVESSALDQRKGKTLEKERTKEAELLREEQARWERHPFSCREDAEQALASLKTSLRPRFHQVKAAVEEIVRPKKRRGRPKKGAEPEMETRYLLRLDVEFDQNAWEQARRKASRFVLVTTVPEEWKGQQMDAQEILKLYKGQISVEMNFAFLKDPFFTDEIYVKKPERVAVLGYLFLLALAIYRVFQRRVRQFITPEHPLKGAGGRKLTRPTGQAIFQLFQYVNVVLLELPDGRIQRSLDRSLTPEQRRILQGLGLDESIYV
>NZ_CP014335.1|WP_062898338.1|301258_302059_-|AAA-family-ATPase
MYKTFYSLSREPFSKETNPPEAYQGASYQEALAALDYVKRTRGIGLLIGEPGAGKTFALRAFKESLNPSLYHVVYFPLSTGSVMDFYRGLAFGLGEEPKYRKVDLFYQIQQGIERLYHEQRVTSVFILDEMHLAKDAFLQDIAILFNFHMDSTNPFVLILAGLPHLQAKLRLNQHRPLHQRIIMRYQMGPLDKEEVVGYIEHRLKQAGAKHSIFTPAALEAIALQSQGWPRIINNLATTCLLYGAQLKKHMIDEDIVRMAAEEMGY
>NZ_CP014335.1|WP_015374208.1|302051_303299_-|IS481-family-transposase
MNESMRQEIALFRYGLIAPLVNGQVDPKTYLKEVAERIHQVPHHGEKRIAAKTILDWCTQYKKGGFEALKPKRRSDRGHSRRLSPEEEDHILALRKKHPHMPVTVFYQHLIEQGEIQSISYFTIYRLLKKYNLVGKEILPIPERKRFAYDQVNELWQGDLSHGPLIRVNGKTQKTFLIAYIDDCSRVVPYAQFFSSEKFDGLRIVTKEALLRYGKPKRIYSDNGKIYRAEPLQYACAELGITLIHTQPYDPQSKGKIERFFRTVQTRFYPLLEMNSPKSLEELNERFWKWLEEDYHRKPHASLNGKTPHEVFQSQVHLVSFVDDSDWLDSIFLKREYRKVKADGTVTLNKQLYEVPPRFIGQSIELRYDEQGVYVYEDGQRVAEAVLVRFEDNAYVKRHRSPFAAVPVEGGENDV
>NZ_CP014335.1|WP_011229674.1|303449_304013_-|transposase
MIRFHDFQVDVQTYAQRGKQNDFPLLKRCPHCQAKRPLYRHGYYERNAVTSHQSYRIWIARYRCPECRRTVAVLPSFLLPYFQYTLPTIWRVVKERLGLTPKRGMEEAPLLPTDEGVLFYVRRLFRNLNHLHWFFAERWRKIGPAIAQARERALWWIQTMEEIGLFFVIQEIWEHRSTHLFARTFSS
>NZ_CP014335.1|WP_062899080.1|305728_306262_+|sigma-70-family-RNA-polymerase-sigma-factor
MIRLIKRAQKGDREAFLKIFQPYEGEIYRIAFIYLKNKDDALDVVQETAYRAFKSIISLREPKYFKTWLISIAIRCALDIIRSQKKITLIENYDVVESQVSKQDIDDNIPNSVTIKDLIEKLSLDEKNVIILRFYNSCTIQEVADILNIPLGTAKTILYRALKKLQKEWKGDDVCEQ
>NZ_CP014335.1|WP_062898339.1|306251_306887_+|hypothetical-protein
MSNKITQEINKIEVPKEVHTRSKLGIQKAKLELKKPKRKWVLVLAPVMIAFISIIYFVPNYFTNTPPKNPIIKSIDLNYAIDISNPREVVGFSDNVFVGKVVKQVGTRNRDYPETQFEVEVLYNIKGEVNGTIKVNQVGGYEGDYLFLMEGDKLIEEGQTYLFATRYLAEEKWHTLIPVGGDIPINSDVEKKELIEKYTKAYKEEIPFKVD
>NZ_CP014335.1|WP_062898340.1|307034_308168_-|IS4-family-transposase
MNKHTTLPNLMQKLVSDEEIQLIAEAVGYRDSSRTFTLRELIHFFLLAAMHQWKSFRHGADVGPLYGLPRFHYSTVSKKAKEVPYDIMKRLLALIISKCNRQTRRSLRFPKPLRVVDSTTVTVGKNRLPWAPYHGERAGVKLHVAYSPESSLPADVVETIGLRHDGPVGEQLTNAQQVLVEDRAYFKIERLDRFVEQHQLFVIRMKDNIELHQKKSLKRLSSTSSSVQADFTCQLGTKQCRSTKRHRVVIFRDANGRDIRVVTNLFHASAETIADMYQQRWTVEVFFRWVKQYLNVPTLFGTTENAVYNQLFGAFIAYVLLRWLYDQTKKRTNVSLSFISFVRRFFSGQLPLDWKSGMAAALFEYAQIYGRRMSNFG
>NZ_CP014335.1|WP_082816466.1|311420_311816_+|transposase
MGYTESEKVELKKEFLRMLVRLELDEARQRLLLGFFETYVKLSEEEEQQLQREVRAMETKEKENVLELIISYEQKGRKQGLEEGIKQGMKQGMKQGMKQLIRNMARKGMTVEDIARLVDLSEEDVRGLLRE
>NZ_CP014335.1|WP_011229827.1|312731_312956_-|hypothetical-protein
MQQRQRKAVNNHAWWINGAIQKKQMPKRSPCAKQKSGFLQSKRRKNEQPKQNEAVDRGSAAIRFLQTEDVHTMA
>NZ_CP014335.1|WP_062898341.1|313092_314148_+|P1-family-peptidase
MRRKLRDLGFSIGTLPTGERNQVTDVPGVRVGHVTIREDMNERTVIRTGVTAVLPHGGNWFLEKVPAACFVLNGFGKTVGLVQVEELGLIESPIMLTNTFSVGAVWQGTLEYMLAMTPEIGDTTGSANIVVGECNDSYLNTARALSVTKEHAKQAIAEARVDMEEGAIGAGTGMMCFGWKGGIGSSSRIAGGMYTVGALVVSNFGRREELRFVPYVPPSFDERDVPAGSIMMIVATDAPLDARQLKRLAKRAAVGLARTGSHVHHGSGDIVIAFSTAYTVPHFVDSAHQALPPLVRDDAPLMNELFQAAVEATEEAIWNSLTMAETTTGRNGRVGEAIPYSLLRWIKWTEK

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Crispr_ID: NZ_CP014335_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014335_2

312362-312721

TypeV

Consensus_repeat	Method
GTTTTTATCGTACCTATGAGGGATTGAAAC	PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	CRT

5 spacers

The CRISPR arrays of NZ_CP014335_2

>merge|NZ_CP014335|2|312362-312721|PILER-CR,CRISPRCasFinder,CRT
GTTTTTATCGTACCTATGAGGGATTGAAACAGAACACGTCGCAGTCGGCAAGCTCCGCGCAAAGCGCGTTTTTATCGTACCTATGAGGGATTGAAACTTGCGCCGGAGGGGAAAATCTACGAACAAGCATACGTTTTTATCGTACCTATGAGGGATTGAAACAACTAACATCACTAAAATATTTTTTTGCCGTTCCCGTTTTTATCGTACCTATGAGGGATTGAAACCGCGATGTACGCGGAGCGAAAGCCGATGCCACGATCCGGTTTTTATCGTACCTATGAGGGATTGAAACCGGAGTCGGCCGCTTTCTCCATGCGTTTCCGCCCAGTTTTTGTCGCGCCTATAAGAGGCGAAACC

>NZ_CP014335|2|2|312362-312656|PILER-CR
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGAACACGTCGCAGTCGGCAAGCTCCGCGCAAAGCGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGCGCCGGAGGGGAAAATCTACGAACAAGCATAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACTAACATCACTAAAATATTTTTTTGCCGTTCCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGCGATGTACGCGGAGCGAAAGCCGATGCCACGATCCG
GTTTTTATCGTACCTATGAGGGATTGAAAC

>NZ_CP014335|2|1|312362-312656|CRISPRCasFinder
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGAACACGTCGCAGTCGGCAAGCTCCGCGCAAAGCGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGCGCCGGAGGGGAAAATCTACGAACAAGCATAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACTAACATCACTAAAATATTTTTTTGCCGTTCCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGCGATGTACGCGGAGCGAAAGCCGATGCCACGATCCG
GTTTTTATCGTACCTATGAGGGATTGAAAC

>NZ_CP014335|2|2|312362-312721|CRT
GTTTTTATCGTACCTATGAGGGATTGAAAC	AGAACACGTCGCAGTCGGCAAGCTCCGCGCAAAGCGC
GTTTTTATCGTACCTATGAGGGATTGAAAC	TTGCGCCGGAGGGGAAAATCTACGAACAAGCATAC
GTTTTTATCGTACCTATGAGGGATTGAAAC	AACTAACATCACTAAAATATTTTTTTGCCGTTCCC
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGCGATGTACGCGGAGCGAAAGCCGATGCCACGATCCG
GTTTTTATCGTACCTATGAGGGATTGAAAC	CGGAGTCGGCCGCTTTCTCCATGCGTTTCCGCCCA
GTTTTTGTCGCGCCTATAAGAGGCGAAACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014335.1\|WP_062898344.1\|322869_324075_+\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP014335.1\|WP_082816466.1\|311420_311816_+\|transposase	unknown	unknown	gnl\|CDD\|273806
NZ_CP014335.1\|WP_023633344.1\|315662_316316_-\|PspA/IM30-family-protein	unknown	unknown	gnl\|CDD\|224755
NZ_CP014335.1\|WP_023633343.1\|316275_316800_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_082816465.1\|298216_298582_+\|transposase	unknown	unknown	gnl\|CDD\|273806
NZ_CP014335.1\|WP_062898336.1\|296928_298149_+\|TIGR02679-family-protein	unknown	unknown	gnl\|CDD\|274255
NZ_CP014335.1\|WP_062898337.1\|299276_300935_-\|IS1634-family-transposase	unknown	unknown	gnl\|CDD\|379471
NZ_CP014335.1\|WP_062898343.1\|322024_322696_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP014335.1\|WP_062898338.1\|301258_302059_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|225806
NZ_CP014335.1\|WP_015374208.1\|302051_303299_-\|IS481-family-transposase	unknown	unknown	gnl\|CDD\|366234
NZ_CP014335.1\|WP_011229832.1\|316999_317323_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_023633341.1\|320670_322044_-\|GHKL-domain-containing-protein	unknown	unknown	gnl\|CDD\|380161
NZ_CP014335.1\|WP_011229827.1\|312731_312956_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_011229829.1\|314230_315463_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340949
NZ_CP014335.1\|WP_062899080.1\|305728_306262_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|213752
NZ_CP014335.1\|WP_011229674.1\|303449_304013_-\|transposase	unknown	unknown	unknown
NZ_CP014335.1\|WP_062898341.1\|313092_314148_+\|P1-family-peptidase	unknown	unknown	gnl\|CDD\|239071
NZ_CP014335.1\|WP_062898340.1\|307034_308168_-\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NZ_CP014335.1\|WP_062898339.1\|306251_306887_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_062898342.1\|317707_320017_-\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428

Protein	Function_ID	Function_description	E-value
NZ_CP014335.1\|WP_082816466.1\|311420_311816_+\|transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	5.55379e-05
NZ_CP014335.1\|WP_023633344.1\|315662_316316_-\|PspA/IM30-family-protein	gnl\|CDD\|224755	COG1842, PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].	3.99862e-20
NZ_CP014335.1\|WP_082816465.1\|298216_298582_+\|transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	1.32727e-06
NZ_CP014335.1\|WP_062898336.1\|296928_298149_+\|TIGR02679-family-protein	gnl\|CDD\|274255	TIGR02679, conserved_hypothetical_protein, TIGR02679 family protein. Members of this protein belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). [Hypothetical proteins, Conserved].	2.5046e-134
NZ_CP014335.1\|WP_011229829.1\|314230_315463_-\|MFS-transporter	gnl\|CDD\|340949	cd17391, MFS_MdtG_MDR_like, Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.45771e-115
NZ_CP014335.1\|WP_062898343.1\|322024_322696_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	8.138e-79
NZ_CP014335.1\|WP_062898338.1\|301258_302059_-\|AAA-family-ATPase	gnl\|CDD\|225806	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion].	2.6389e-38
NZ_CP014335.1\|WP_015374208.1\|302051_303299_-\|IS481-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	7.89716e-22
NZ_CP014335.1\|WP_062898344.1\|322869_324075_+\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	5.07374e-96
NZ_CP014335.1\|WP_062899080.1\|305728_306262_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|213752	TIGR02954, RNA_polymerase_ECF-type_sigma_factor, RNA polymerase sigma-70 factor, TIGR02954 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family. This family is found in certain Bacillus and Clostridium species.	1.80608e-44
NZ_CP014335.1\|WP_062898337.1\|299276_300935_-\|IS1634-family-transposase	gnl\|CDD\|379471	pfam14104, DUF4277, Domain of unknown function (DUF4277). This presumed domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is approximately 110 amino acids in length. There is a conserved NGLGF sequence motif.	9.71941e-32
NZ_CP014335.1\|WP_062898341.1\|313092_314148_+\|P1-family-peptidase	gnl\|CDD\|239071	cd02253, DmpA, L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active heterodimeric form. The cleavage results in two polypeptide chains, with one chain containing an N-terminal nucleophile. This group represents one of the rare aminopeptidases that are not metalloenzymes. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.64573e-174
NZ_CP014335.1\|WP_062898340.1\|307034_308168_-\|IS4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	1.35958e-25
NZ_CP014335.1\|WP_023633341.1\|320670_322044_-\|GHKL-domain-containing-protein	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	1.17966e-72
NZ_CP014335.1\|WP_062898342.1\|317707_320017_-\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	6.73532e-155

>NZ_CP014335.1|WP_082816466.1|311420_311816_+|transposase
MGYTESEKVELKKEFLRMLVRLELDEARQRLLLGFFETYVKLSEEEEQQLQREVRAMETKEKENVLELIISYEQKGRKQGLEEGIKQGMKQGMKQGMKQLIRNMARKGMTVEDIARLVDLSEEDVRGLLRE
>NZ_CP014335.1|WP_062898340.1|307034_308168_-|IS4-family-transposase
MNKHTTLPNLMQKLVSDEEIQLIAEAVGYRDSSRTFTLRELIHFFLLAAMHQWKSFRHGADVGPLYGLPRFHYSTVSKKAKEVPYDIMKRLLALIISKCNRQTRRSLRFPKPLRVVDSTTVTVGKNRLPWAPYHGERAGVKLHVAYSPESSLPADVVETIGLRHDGPVGEQLTNAQQVLVEDRAYFKIERLDRFVEQHQLFVIRMKDNIELHQKKSLKRLSSTSSSVQADFTCQLGTKQCRSTKRHRVVIFRDANGRDIRVVTNLFHASAETIADMYQQRWTVEVFFRWVKQYLNVPTLFGTTENAVYNQLFGAFIAYVLLRWLYDQTKKRTNVSLSFISFVRRFFSGQLPLDWKSGMAAALFEYAQIYGRRMSNFG
>NZ_CP014335.1|WP_062898339.1|306251_306887_+|hypothetical-protein
MSNKITQEINKIEVPKEVHTRSKLGIQKAKLELKKPKRKWVLVLAPVMIAFISIIYFVPNYFTNTPPKNPIIKSIDLNYAIDISNPREVVGFSDNVFVGKVVKQVGTRNRDYPETQFEVEVLYNIKGEVNGTIKVNQVGGYEGDYLFLMEGDKLIEEGQTYLFATRYLAEEKWHTLIPVGGDIPINSDVEKKELIEKYTKAYKEEIPFKVD
>NZ_CP014335.1|WP_062899080.1|305728_306262_+|sigma-70-family-RNA-polymerase-sigma-factor
MIRLIKRAQKGDREAFLKIFQPYEGEIYRIAFIYLKNKDDALDVVQETAYRAFKSIISLREPKYFKTWLISIAIRCALDIIRSQKKITLIENYDVVESQVSKQDIDDNIPNSVTIKDLIEKLSLDEKNVIILRFYNSCTIQEVADILNIPLGTAKTILYRALKKLQKEWKGDDVCEQ
>NZ_CP014335.1|WP_011229674.1|303449_304013_-|transposase
MIRFHDFQVDVQTYAQRGKQNDFPLLKRCPHCQAKRPLYRHGYYERNAVTSHQSYRIWIARYRCPECRRTVAVLPSFLLPYFQYTLPTIWRVVKERLGLTPKRGMEEAPLLPTDEGVLFYVRRLFRNLNHLHWFFAERWRKIGPAIAQARERALWWIQTMEEIGLFFVIQEIWEHRSTHLFARTFSS
>NZ_CP014335.1|WP_015374208.1|302051_303299_-|IS481-family-transposase
MNESMRQEIALFRYGLIAPLVNGQVDPKTYLKEVAERIHQVPHHGEKRIAAKTILDWCTQYKKGGFEALKPKRRSDRGHSRRLSPEEEDHILALRKKHPHMPVTVFYQHLIEQGEIQSISYFTIYRLLKKYNLVGKEILPIPERKRFAYDQVNELWQGDLSHGPLIRVNGKTQKTFLIAYIDDCSRVVPYAQFFSSEKFDGLRIVTKEALLRYGKPKRIYSDNGKIYRAEPLQYACAELGITLIHTQPYDPQSKGKIERFFRTVQTRFYPLLEMNSPKSLEELNERFWKWLEEDYHRKPHASLNGKTPHEVFQSQVHLVSFVDDSDWLDSIFLKREYRKVKADGTVTLNKQLYEVPPRFIGQSIELRYDEQGVYVYEDGQRVAEAVLVRFEDNAYVKRHRSPFAAVPVEGGENDV
>NZ_CP014335.1|WP_062898338.1|301258_302059_-|AAA-family-ATPase
MYKTFYSLSREPFSKETNPPEAYQGASYQEALAALDYVKRTRGIGLLIGEPGAGKTFALRAFKESLNPSLYHVVYFPLSTGSVMDFYRGLAFGLGEEPKYRKVDLFYQIQQGIERLYHEQRVTSVFILDEMHLAKDAFLQDIAILFNFHMDSTNPFVLILAGLPHLQAKLRLNQHRPLHQRIIMRYQMGPLDKEEVVGYIEHRLKQAGAKHSIFTPAALEAIALQSQGWPRIINNLATTCLLYGAQLKKHMIDEDIVRMAAEEMGY
>NZ_CP014335.1|WP_062898337.1|299276_300935_-|IS1634-family-transposase
MNVQVKKVYRNSYLNIISALFKKLGLPQLIDHLVPVDPQCQTRVSDAVQAILYNVFDGRQALVHLEHWAQEVDCEKLIRPDLHPSWLNDDALARHLDRLYEAGIHNVISTCLIHIYRKEGLSLRAFHADTTDKTVYGAYESASLEALQITHGYNRHHRWQKQIGFGLVGNEDGIPFYDDVHDGNLPDKTWNPEVLSRVHEQLKQAKIEDEWIYVADSAAMTKETLAQTKAANAFLITRGPSSLRIVKTALAEADAEDTTWSDPFTLAERNGATYRVWETASTYEGHPVRLIVVESSALDQRKGKTLEKERTKEAELLREEQARWERHPFSCREDAEQALASLKTSLRPRFHQVKAAVEEIVRPKKRRGRPKKGAEPEMETRYLLRLDVEFDQNAWEQARRKASRFVLVTTVPEEWKGQQMDAQEILKLYKGQISVEMNFAFLKDPFFTDEIYVKKPERVAVLGYLFLLALAIYRVFQRRVRQFITPEHPLKGAGGRKLTRPTGQAIFQLFQYVNVVLLELPDGRIQRSLDRSLTPEQRRILQGLGLDESIYV
>NZ_CP014335.1|WP_082816465.1|298216_298582_+|transposase
MLVRLELDEAKQRLLFGFFETYLRLSEEEEAKPRHEVSQMETKEAKRVMELIVSYEQRGLEKGIQQGIEQGLKQGMKQGRQEGIEEGKLDVVKRMLAKGYDVDTIHELTGLPMEKIERMKG
>NZ_CP014335.1|WP_062898336.1|296928_298149_+|TIGR02679-family-protein
MSTVKEAAAFFRSERAFHRLFVEMKRKYESLGRVGGTVSLQSFSDEEREAIAAFFGKDVSRVSLIAFEKQLGQTRFAGVGLVELLEQYFGAPLVSNKERRQAEEEERDRFFARLTEEHHWVESVRPQRFVQTAYETDRRSLEEAIRLVSAALGRLPLPSYMRLPLFAQQVAGDPHAFDLSTLPGRLLLSALQATVPGDWDMASVESVNELLQSVGLLREDILNFVTCANILAETKDGPHPVFSAAWEANTALNMPLRDVLSLVRARPAHGGTVYIVENAGVFSTLLDTRAPLVSTNGQMNLATMKLLDLLASSGAKLYYSGDFDPEGLAMAERLQERYGQAVTLWRFSVEDYRAANPVVDLTPERLAKLASVTSTPLQPLKEEMAETKKAGYQEAIIGRLTEDING
>NZ_CP014335.1|WP_011229827.1|312731_312956_-|hypothetical-protein
MQQRQRKAVNNHAWWINGAIQKKQMPKRSPCAKQKSGFLQSKRRKNEQPKQNEAVDRGSAAIRFLQTEDVHTMA
>NZ_CP014335.1|WP_062898341.1|313092_314148_+|P1-family-peptidase
MRRKLRDLGFSIGTLPTGERNQVTDVPGVRVGHVTIREDMNERTVIRTGVTAVLPHGGNWFLEKVPAACFVLNGFGKTVGLVQVEELGLIESPIMLTNTFSVGAVWQGTLEYMLAMTPEIGDTTGSANIVVGECNDSYLNTARALSVTKEHAKQAIAEARVDMEEGAIGAGTGMMCFGWKGGIGSSSRIAGGMYTVGALVVSNFGRREELRFVPYVPPSFDERDVPAGSIMMIVATDAPLDARQLKRLAKRAAVGLARTGSHVHHGSGDIVIAFSTAYTVPHFVDSAHQALPPLVRDDAPLMNELFQAAVEATEEAIWNSLTMAETTTGRNGRVGEAIPYSLLRWIKWTEK
>NZ_CP014335.1|WP_011229829.1|314230_315463_-|MFS-transporter
MNWKRSVRVLWLCNFMVSAGMTMVIPFLSLFLWQMGVTEHHALSIWTGLVFSVTFLSAAVMAPIWGVFADKYGQRANLIRAGIGMGLITGCMAFAASPMTLLALRFLVGFFSGFITVSFSYLARVVPRDHSGEALGTLQTGSIAGNIIGPLIGGALSDLFGFRPVFLVTGLCILLTLLPVIFWLEKDPVVPQTKENKASFKEVFRHRPLIVLFIATFLVQIAVLGVNSMMTIFVQSLIGHSSNLAFLSGLASSITGIATIIGAPYLGKLGDRIGQEKTLPILLVLSGLFALPQVWTDNIYELYVWRFLQGLVVGGVWPSIQALINAQSPRRIQGRVFGVTASSRFLGNLTGPTAAGAIAGFFSISSIFVLSGLLLIATGALVGYATHDRAWREEMKEKIAAWTHRLHSRY
>NZ_CP014335.1|WP_023633344.1|315662_316316_-|PspA/IM30-family-protein
MGIFRRIKTIILAEANEQIDRWEDPVAMTKQYLRQLEQQLEQGRQALTQQWVAERRYETLIAQAEATIEKRSRQAKLALERNEESVAKLALRDKLLYEKKLEAYKQQYEAIKAKTVEVANRLNQLRERYDELAAKQLELAARVNAAQALKQIDTALASFSADEALRGFARMEERVIALEAEAAAARFGTNAALSPVPFEEEVERELAKWKEAQANNA
>NZ_CP014335.1|WP_023633343.1|316275_316800_-|hypothetical-protein
MKKAKTFLFIALAALVGWSAFHVLTPHEVMAHGRPGVPFAGVHDGFGHHHREFGMGSREGWMMAGLFMWWLIPFLLVGAGAIWLAAARSKRWIGWALVALGVAAILPKWVLILLALAAVYTLGRRQARKTAIAEVWAPALPSVPVDWLDEWEKTIQKEAKQHGHFSPDQNDYSR
>NZ_CP014335.1|WP_011229832.1|316999_317323_+|hypothetical-protein
MVRSYGLDVGGALFVFLFSFLFPTFDVGYYAYGSFLGFAIGSLIVGLARIRWNPHARLGGALIGLFLIIAISVIIIRLFPIEIRDVGDLVMPYVNAIVNACFCCNLF
>NZ_CP014335.1|WP_062898342.1|317707_320017_-|YhgE/Pip-domain-containing-protein
MRAFQLWMQEWKAVASNRKTLIPIIAVLFIPLLYSGMFLWAFWDPYDHLDELPVAVVNKDKGTTFEGKAFHLGDDLVEKLKEKKQFNWHFVNEHEGEKGLKEQKYYMLIQIPEDFSQNATTLQDDHPKKLQLIYKPNEGFNFLSAQIGGTAVEKIKTEVAKTLTETYAENMFENIQTLADGLTKASDGAKQLHDGLGEAKNGTNKLYDGMKKAEDGSKDLHHHLATLAEKSMAFTDGLNQAVNGSTQVQAGVQMLDNGMKHMVDGQGQLLDGAKQAQEGTANLASGAKRVYEGMQTLDARMPQLLQGSEQLSGGAEKLASSLAQWQQGAARVQTGATQVTGGLEQLAAQLDALIAQTPDPTQKAVYERLKENVEKLSFGSKQVENGIAQLNDGAKALQSGAASLNSGAKQLHEGHIALDRGVDELLSGQQQLVNGANALLNGQEKLVAGMNTLHEKMKEAEQGADKLANGGQTLTSGLQVLAQGADRLQDGAHQLADGSQQLASGMNELTSGTRHLQNGMNRLTDGSEELADQLKEGAKKASDVKANKDVYDMFAEPVKVKNEKVNEVPNYGTGFTPYFLSLGLFVGALLLSIVFPLREPAAVPRSPFHWFFAKFGVLIGVGIFQALLADSVLLYGLDLQVKSVPFFILFSVVTSIAFLSVIQFLVTTFGDPGRFIGIVVLILQLTTSAGTFPLELIPRSLQHFNAWLPMTYSVFGFKAVISSGDFSFMWENIGKLLLFIVAMMVGTMAYFTMQHRRRFATAVEQASEA
>NZ_CP014335.1|WP_023633341.1|320670_322044_-|GHKL-domain-containing-protein
MINRWNEWRDWLRRLESADLFRRAHWRLTALYSGIFTLFLALFILIAAALFYWITTSDQERRITRLAEQEANTIEQFLLKQSDFDLFHDESVVLLSEDQLFFYVIGPNGDLLAGDEIHPRLRPYFLNVLSRMDTGERTPVYVTVSLPEHMPGLARAAARDWRVLAVAYPLIIHGDFAGMLYIGMDVTSFFGVFHWLLVVLIGLAVLFLAVGVALSYFMSKRALIPIEEAYERQRQFVADASHELRTPLSVVFSSVEALALEEDVMKNDFAHRLLDRLREELKRITKLMNDLLTLARADAKNAALELSKQTFDFRPHAERTFQLVSELAAKKQITMHFHAPEQAIVTADPDKLTQLLYILLDNAIKYTPEGGDVTLSIRTEPKQFILSVKDTGIGIPPEDIGRIFDRFYRVDKTRSRQQGGHGLGLSIAKWIVEAHGGTIHVQSQLGQGSEFLVRLPA
>NZ_CP014335.1|WP_062898343.1|322024_322696_-|response-regulator-transcription-factor
MKILLAEDDLHLGELIVHLLKKKGIDHIDWVQEGEDAYDYAMAEFYDVVVLDWMLPNGDGVDICSRLRQNGYTGAILMLTAKDAVQDRVTGLEAGADDYLVKPFEIDELVARLKALARRTFVPLQEEKVTFHGFTLNRTSHTLHRGDEEIFLTPREFQLLDLLVQNQGQVVPRETILDRVWGWDADVSMKTIDATIKLLRKKLKDDVIQTVRGVGYKIDKSME
>NZ_CP014335.1|WP_062898344.1|322869_324075_+|PDZ-domain-containing-protein
MDMMPFEPTPTPQPKRRGRFVSWLAASVAGAVIGSAATWYVAPKWIYGETHSQTEAAETTAKSEALPLQPTANVKTNMIDAINKVADAVVGVVNIQKQVDFFSDQAQDTEAGTGSGVIFKKEGNVAYIVTNNHVIEGANKVEVALPNGKKVKADIVGADALTDLAVLKIPANGVTKVASFGDSSKVKIGEPVAAIGNPLGLDLSRTVTEGIVSGKRTMPVSTSAGDWEIDVIQTDAAINPGNSGGALINSAGQVIGINSMKIAETGVEGLGFAIPSENVKPIIEQLMKDGKIKRPYLGVQLVDVADLSDEVRADELKLPSNVTYGAAITSVEPFSPAADAGLKSKDVIVAINGDKIDSVSALRKYLYTKTSVGNRIKLTIYRDGFETTVSVTLKARDSSQS

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Crispr_ID: NZ_CP014335_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014335_3

965075-965168

Orphan

Consensus_repeat	Method
GTAGACACAAAATATAGTGCGGAAGAATCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP014335_3

>merge|NZ_CP014335|3|965075-965168|CRISPRCasFinder
GTAGACACAAAATATAGTGCGGAAGAATCGATTGCGGAAATGAGAGTGAAAACAAGGAAAATTCGTAGACACAAAATATAGTGCGGAAGAATCG

>NZ_CP014335|3|2|965075-965168|CRISPRCasFinder
GTAGACACAAAATATAGTGCGGAAGAATCG	ATTGCGGAAATGAGAGTGAAAACAAGGAAAATTC
GTAGACACAAAATATAGTGCGGAAGAATCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014335.1\|WP_014195324.1\|955605_955824_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_062898510.1\|961526_962111_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380061
NZ_CP014335.1\|WP_014195334.1\|973116_973551_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372949
NZ_CP014335.1\|WP_020278635.1\|970586_971609_+\|HEAT-repeat-family-protein	unknown	unknown	gnl\|CDD\|237512
NZ_CP014335.1\|WP_011230528.1\|957779_958991_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173844
NZ_CP014335.1\|WP_011230532.1\|962209_963268_+\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NZ_CP014335.1\|WP_062898509.1\|959813_961433_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|341259
NZ_CP014335.1\|WP_014195328.1\|963277_964060_+\|2-phosphosulfolactate-phosphatase	unknown	unknown	gnl\|CDD\|377205
NZ_CP014335.1\|WP_011230526.1\|955926_956712_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187602
NZ_CP014335.1\|WP_011230537.1\|967065_968058_+\|magnesium/cobalt-transporter-CorA	unknown	unknown	gnl\|CDD\|213365
NZ_CP014335.1\|WP_011230538.1\|968134_968785_+\|DUF1906-domain-containing-protein	unknown	unknown	gnl\|CDD\|119380
NZ_CP014335.1\|WP_020278634.1\|973619_974489_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NZ_CP014335.1\|WP_011230527.1\|956738_957605_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NZ_CP014335.1\|WP_033012407.1\|975616_976834_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|371022
NZ_CP014335.1\|WP_031212924.1\|968958_970587_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP014335.1\|WP_011230535.1\|965331_966489_-\|aminotransferase-A	unknown	unknown	gnl\|CDD\|236075
NZ_CP014335.1\|WP_014195329.1\|964056_965031_+\|NADPH:quinone-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|176203
NZ_CP014335.1\|WP_011230544.1\|974632_975400_+\|2,4-dienoyl-CoA-reductase	unknown	unknown	gnl\|CDD\|181077
NZ_CP014335.1\|WP_011230536.1\|966642_966870_-\|IDEAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|235145
NZ_CP014335.1\|WP_011230529.1\|959009_959792_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181295

Protein	Function_ID	Function_description	E-value
NZ_CP014335.1\|WP_020278635.1\|970586_971609_+\|HEAT-repeat-family-protein	gnl\|CDD\|237512	PRK13800, PRK13800, fumarate reductase/succinate dehydrogenase flavoprotein subunit.	0.00106908
NZ_CP014335.1\|WP_062898510.1\|961526_962111_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	8.75806e-37
NZ_CP014335.1\|WP_014195334.1\|973116_973551_-\|hypothetical-protein	gnl\|CDD\|372949	pfam14177, YkyB, YkyB-like protein. The YkyB-like protein family includes the B. subtilis YkyB protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length. There are two conserved sequence motifs: NRHAKTA and HLG.	5.68626e-75
NZ_CP014335.1\|WP_011230528.1\|957779_958991_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	0
NZ_CP014335.1\|WP_011230532.1\|962209_963268_+\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	3.18791e-86
NZ_CP014335.1\|WP_062898509.1\|959813_961433_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|341259	cd05936, FC-FACS_FadD_like, Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD. This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	0
NZ_CP014335.1\|WP_014195328.1\|963277_964060_+\|2-phosphosulfolactate-phosphatase	gnl\|CDD\|377205	pfam04029, 2-ph_phosp, 2-phosphosulpholactate phosphatase. Thought to catalyze 2-phosphosulpholactate = sulpholactate + phosphate. Probable magnesium cofactor. Involved in the second step of coenzyme M biosynthesis. Inhibited by vanadate in Methanococcus jannaschii. Also known as the ComB family.	1.13745e-79
NZ_CP014335.1\|WP_011230526.1\|955926_956712_+\|SDR-family-oxidoreductase	gnl\|CDD\|187602	cd05344, BKR_like_SDR_like, putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR. This subgroup resembles the SDR family, but does not have a perfect match to the NAD-binding motif or the catalytic tetrad characteristic of the SDRs. It includes the SDRs, Q9HYA2 from Pseudomonas aeruginosa PAO1 and APE0912 from Aeropyrum pernix K1. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.80788e-105
NZ_CP014335.1\|WP_011230537.1\|967065_968058_+\|magnesium/cobalt-transporter-CorA	gnl\|CDD\|213365	cd12831, TmCorA-like_u2, Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family. This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.93122e-178
NZ_CP014335.1\|WP_011230538.1\|968134_968785_+\|DUF1906-domain-containing-protein	gnl\|CDD\|119380	cd06418, GH25_BacA-like, BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of Bacillus subtilis. BacA has a C-terminal catalytic glycosyl hydrolase family 25 (GH25) domain and an N-terminal peptidoglycan-binding domain comprised of three alpha helices which is similar to a domain found in matrixins.	6.50232e-46
NZ_CP014335.1\|WP_020278634.1\|973619_974489_-\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.07436e-69
NZ_CP014335.1\|WP_011230527.1\|956738_957605_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	6.27398e-126
NZ_CP014335.1\|WP_033012407.1\|975616_976834_+\|EAL-domain-containing-protein	gnl\|CDD\|371022	pfam10388, YkuI_C, EAL-domain associated signalling protein domain. In Bacillus species this highly conserved region of the YkuI protein lies immediately downstream of the EAL (diguanylate cyclase/phosphodiesterase domain 2) pfam00563 domain so that together they form a monomer which dimerizes for its enzymatic action. The region contains three alpha helices and five beta strands and is the C-terminal half of the structure.	7.19276e-103
NZ_CP014335.1\|WP_031212924.1\|968958_970587_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.27597e-53
NZ_CP014335.1\|WP_011230535.1\|965331_966489_-\|aminotransferase-A	gnl\|CDD\|236075	PRK07683, PRK07683, aminotransferase A; Validated.	0
NZ_CP014335.1\|WP_014195329.1\|964056_965031_+\|NADPH:quinone-oxidoreductase-family-protein	gnl\|CDD\|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	8.03154e-118
NZ_CP014335.1\|WP_011230544.1\|974632_975400_+\|2,4-dienoyl-CoA-reductase	gnl\|CDD\|181077	PRK07677, PRK07677, short chain dehydrogenase; Provisional.	0
NZ_CP014335.1\|WP_011230536.1\|966642_966870_-\|IDEAL-domain-containing-protein	gnl\|CDD\|235145	PRK03636, PRK03636, hypothetical protein; Provisional.	1.40991e-12
NZ_CP014335.1\|WP_011230529.1\|959009_959792_+\|SDR-family-oxidoreductase	gnl\|CDD\|181295	PRK08213, PRK08213, gluconate 5-dehydrogenase; Provisional.	3.73524e-161

>NZ_CP014335.1|WP_014195329.1|964056_965031_+|NADPH:quinone-oxidoreductase-family-protein
MKFVQFVEYGGPDVLRVCEGERPKPTGRQVVIEAEAIGVNYADTARREGRYVVPTPLPFIPGTEVAGVVREVGPEVQTVLPGQRVVALIESGGYAEFVAVDERAVVPLPDGMDARQAAALPVQGLSAYHILKTMGRLEEGETVLVHAAAGGVGTIAVQLAKRFGAKMVIATASTEEKRALAKQLGADVTIDYTKDSWAADVMEATGGRGVDVALEMAGGDVFHQTLDCLAPFGRLVVYGAASGEMTRLNPVRLMAKNWSVIGFFLPQIMKKRALYEQSLRELLAWVQEGSLKLMIGGVYPLEQASEVHRLLQGRKTHGKLLLVP
>NZ_CP014335.1|WP_014195328.1|963277_964060_+|2-phosphosulfolactate-phosphatase
MTKVHVVLRKEDIDEMALADRKVAVVFDVLLATSSITAVLSAGARSVIPVRDAEEAKEIALRLPEGSYELVGEYEGRTIAGFHPPAPLFLQTVCPGKTVVLSTTNGTVAIRRAQPARAVYAASLLNSPAVSEHICRLHQEETIIVICSGSSGRFCLEDFYGAGYFVHCLIEQGINAAELSDSATAAWFFYRQYSDEGKAKEVLSASRVGRWMTAYGLEKEIDYINRHGSLSAVPKLELGPFGLELRNMASTKVTKEGISP
>NZ_CP014335.1|WP_011230532.1|962209_963268_+|phosphotransferase-family-protein
MTAIIPVRKGEELPAGKLAKFLRTVLPDMPDGELEIQQFSAGRSNLTYLLRCGEWEAVLRRPPFGPVPPKAHDMKRESTWLSEIHPLFPLAPKPFYFCEDESVIGSPFFVMERRHGVVIDSDFPDGITPTEEVCRGISETMVETLVRIHQIDYTNTRLVQMVKPDGFMERQVHGWIQRYERAKTDDIPEAEALMKWLASHIPPQREATVIHYDFKLNNALFAKDDITKMVGLFDWEMSTVGDPLADLAVAMSYWIEEDDPPLIKSGFGRAPVTVRPGFYTREQFIEAYAKKSGRDVSDIHVYLTFAYFKLAVICQQIYYRYRRGQTNDERFRHFGQFVEALIEHAWQLATGR
>NZ_CP014335.1|WP_062898510.1|961526_962111_+|TetR/AcrR-family-transcriptional-regulator
MKEKIMAASIELFEQNGFSETSIQDIVDALGVTKGTFYYYFTSKEELLMDIHLRYIEGLLDEEERIISDKRRPLREKLYDIIFMLIHNVERQGREARIFFREMKHLSEEHLQKVKEKRDLFRYRLQSLIEEGMKSGELRCDLSPSIATLTVLGAANWSYQWFRPDGELTDAEVAKQMVEILLNGMSAPSVSKAE
>NZ_CP014335.1|WP_062898509.1|959813_961433_+|long-chain-fatty-acid--CoA-ligase
MSEKRALSLYPEHISFYMDIPDKTVCDVLHERAAEFGSQPALTFYDKTITYAELEAAVNRFTSSLQALGVQKGDRVAIMLPNCPQYVIAYYGILQAGAIVTQVNPMLVERELAYLLKDSGAETIVIYEPLYPRLAAVRGETAVKQAITVSFGAPPSVSLAEGDVTFDEFLAAGSGAVRPVSIESTHDVAVLQYTGGTTGRSKGAMLTHRNIFANVLQCAEFFKGTFEFGKERYLTVIPLFHVFAMTSGMNLAIYQGAENILLPRFELKEVLETIRGKQPTVFPGVPTMYVAITNTPGVEQYGISSIKTCNSGSAPMPLELMRDFEAKTGAVILEGYGLSEASPVTHCNPPFAARKPGTVGIGMPLTEYKVVDVATGTQELPPGEVGELIIRGPQVMKGYWNMPEETAAALRDGWLYTGDLASIDEEGYVTIVDRKKDLIIAGGYNIYPREIEEVLYEHPAVKEAAAVGVPDPYRGETVKAIIVLKDGMQASEEEILAHCRKNLAAYKVPRIVEFRAELPKTNVGKILRRALREEASHSQ
>NZ_CP014335.1|WP_011230529.1|959009_959792_+|SDR-family-oxidoreductase
MHVLDLFKIEGKTAIVTGGGRGLGEQIAVGLAEAGANVVVCSRKVEACEQVKEKLEQLGVRSLALRCDVTNPEEVKHVVETTVKEFGGIDILVNNSGATWGAPVEEMPLEAWQKVINVNVTGTFLMSQAVGKVMIAKQTGGSIINIASVAGLGGTHPDILNTIGYNTSKGAVITFTRDLAAKWGKHGIRVNAVAPGFFPTKMSKVVLERVGKKVLEHTPLGRFGGEDDLKGAVLFLASPASAFVTGALLVVDGGSHATGI
>NZ_CP014335.1|WP_011230528.1|957779_958991_+|acyl-CoA-dehydrogenase
MDFSYSPKVKELIKKLSAFMEDYIYPNERVYEEQLNTQESRWSGVPPIIEELKEKAKKEGLWNLFLPDSEYGAGLTNVEYAPLCEIMGRSLIAPEVFNCNAPDTGNMEVLVRYGTEEQKKKWLIPLLNGEIRSCFSMTEPDVASSDATNIRASIVRDGDEYVITGRKWWSSGAGDPRCKVAIVMGKTNPDAPKHEQQSMIIVPLDTPGVKIERMLPVFGFDHAPHGHAEITYDHVRVPKENIIWGEGKGFAIAQGRLGPGRIHHCMRLIGAAERALELMCRRVQSRVAFGKPLAEHGVIREWIAQSRIEIEQARLLTLKAAYMMDTVGNKAARKEIAMIKVVAPNVALKVIDRAIQAFGAAGVSNDFPLAAMWANSRTLRLADGPDEVHKEQVAKLELRQYQQ
>NZ_CP014335.1|WP_011230527.1|956738_957605_+|NAD(P)-dependent-oxidoreductase
MKTIGFIGLGVMGKSMARHLLKAGYPLLAYTRTKEKAEDLLQEGAVWKETVADLAREADVVMTMVGDPRDVEQVYFGEGGILENARPGTYVIDMTTSTPTLAQSIYEAAKQKGIHALDAPVSGGDIGAREGTLTIMVGGDEDVFLACKPILERLGTNIVRQGGAGAGQHTKMCNQIAIATNMIGVCEAMAYAKRAGLDPFKVLESIAKGAAGSWSLSNLAPRMLSGDFAPGFYVKHFIKDMKIALEEAERMNLPLPGLALAKQLYEELAQAGEENSGTQALYKRYVKA
>NZ_CP014335.1|WP_011230526.1|955926_956712_+|SDR-family-oxidoreductase
MELGLAGKTALVAASSQGLGKAIARALVLEGTNVMITSRNEEKLHEVAEELNSLHKGRVAYTRTDVTNADDIRQLVAKTVETFGTIDLLVNNAGGPPAGTFETVSDEDWQYAFELNLLSYIRLIREALPYLKKKGGKIVNIASSSIKEPIPGLILSNTFRTGIVGLTKTLAVELAPDGILINTVAPGRIATERVAFLDKVNAEKLGITKEEMEARMKSAIPLGRYGTPEEFANVVVFLLSEANSYVTGQALIVDGGMVKAI
>NZ_CP014335.1|WP_014195324.1|955605_955824_+|hypothetical-protein
MPERGRNDHPHMFYRDGARESVINDPTADGAEAIGVRTDADPMKDANPNPFHVDRLNVEEGMKRFQSFFEER
>NZ_CP014335.1|WP_011230535.1|965331_966489_-|aminotransferase-A
MKHLIQPRVQAIQLSGIRQFFNLVADRPGLVSLTIGQPDFPTPDHVKAAAQEAIAADFTTYTANAGLLELRQAACQFVADKYGLRYTPDEVIATVGASQALDITFRTILEEGTEVLLPAPVYPGYEPLIRLCGAKPVYIDTRPNGFRLSAELIAPYLTEKTRCLVLPYPSNPTGTALSAEELENIASLLKGRPIWIVSDEIYSELVYHGRHHSIAEWLPEQTIVINGLSKSHSMTGWRIGFVFAPAFAVEQMVKVHQYSVSCTSSISQKAAVEALTAGKHDAEAMRAAYAERLEYAYHRLTAMGLPVEKPDGAFYLFPSIAAFGMSSFDFALDVVENAGVALVPGSAFSEYGEGHVRLSYAYSLDVLKEGLDRLERYIQTKRRRP
>NZ_CP014335.1|WP_011230536.1|966642_966870_-|IDEAL-domain-containing-protein
MYEKQYPNEGAVLFNQPEEKSSYGPMAEQVLKEAIFQFQRKKLMEQIDEALAAGNKPLFFKLSAQYNDLLKKYGA
>NZ_CP014335.1|WP_011230537.1|967065_968058_+|magnesium/cobalt-transporter-CorA
MIRTCVVTKEFEILYDVDLTLVNSPDVSWYWVDFHEPTDEESALLASFFRFHPLAIEDCLEYVQRPKLDFYDRYLFVVLHAIAGMTLEAEEVDLFVGQNFIVSFHKSAIHAVDEVWERLKHEEDVQQGPFHVMYRLIDKLVDDYFPPLYHIEDVLNDLEENTNNEPIHDIIEKVFDIRGDLSKLRRTIVPMRDLLYRIIHSDRLQRMKERQLYFHDIYDHLLKLSEMIETNREITADIRDSYLSLNSNRMNNIMMTFTAITTIFMPLSFIAGIYGMNFDYMPELHWKYGYFVVLAAMAVIGMTMFVWFKRNGWFQLLKGDWAKEERERRQ
>NZ_CP014335.1|WP_011230538.1|968134_968785_+|DUF1906-domain-containing-protein
MARGIWGVDSAQAVTDQLFQCVRTELGYPKFWGRYLSEVPNVSEGLTRDEIARIRSYGVKVLPIYNAFREAVGYANGQVAARNAVFHARRLGIPKNKLLFANIEDFFAVDAAWIAAWVETLYPTGYRPGLYADPTKGDFAAAYCEAVSRNNQVAVQAVIWSAAPRPGTTKEQKAPRYQPAAPPCSANVWVWQYGRDAEVCPVDTNLADRRLLDFLY
>NZ_CP014335.1|WP_031212924.1|968958_970587_+|diguanylate-cyclase
MDRSVASLLDRIHEQYERWRTGPPLDGVELARFFNAVGRTAAVIGLSDIAAEAERLIHRLNGQTERQWTAEEALMEMVPLLRCFYEAGEAASATIPSSHRQGPKAAILLCGNDPLFFAYVRGALQTVPWRFTTIPSLEQAAASMFRLSPDCIIVSVKEGEWENPDLTVLLERAGQRPYLPVVIVRRDEGKEGRLKGYELGADDVITTPAADELFVRVRRLIEKKRKIDDLVLIDELTGVYNRKYLPRVYARLRSDLERYGAPSCLALLDLDHFKQVNDRFGHLAGDAVLQKLAAFLRQHTRGVDTVVRFGGEEFVVWLAKTSKSEARAVLERLQRQFAAEKIEADGALLSCTFSAGLVECDEPDRPLDYWLRLADKALYAAKRGGGNRIEEAAREKSGSSDEAPSQASTDRRRWAIAIVDDDELVRMMIADLVRKLVNEQGRKADIYEFGDGLSFLESPFYQSGRQSVVILDRVMPKMDGLEVLNRLRQERKPYKVMLLTSRQDERDIAHALNRGADEYVTKPFKWFELEARLRRLLKELDE
>NZ_CP014335.1|WP_020278635.1|970586_971609_+|HEAT-repeat-family-protein
MALLVVFTAAIALFAVLIVLFLYLVVRKWRENRRQARLRVYKERHRLWLLRYLLGEEEQMLLPASPLEREAMMELLDHFASLLNGEQVQERIRTLAEMHFQGWLHRRLSSRHWSERMNALFLIEDLQVKAMLPEMERLYRSNRVTKGEAAKLLAIFAQFDYSPVIAYVLEPKYKLTEFSYRVIFGHMSERLLRQVEQRFDELPRAGKCAFIDMIGIRRRGERSFLLELLASDELELRVRALKAMAEIGVSIEATKLDRHLRSPHWQERLMAVRLAGKCREEWLLPLLYERLADRSFAVRSEAAASIVRLPGGRAMLHKAACTAEDRYARDMAKQWIGEEG
>NZ_CP014335.1|WP_014195334.1|973116_973551_-|hypothetical-protein
MKPVQLTVDNIAKAIFTVNRHAKTALNPSFLYLLKKKAIEKLLEEGKAKKVGLHFSRNPRYSQQQSDVLVAVGDYYFHIPPTKQDFAALPHLGSLNDSYRNPPARMPLSEAKAILIAYTGLKEKPEQKPKRLTRPVFKRLGDRY
>NZ_CP014335.1|WP_020278634.1|973619_974489_-|metallophosphoesterase
MHHIETTKLSRRAFLKKLARTSFSAALAMAAASGYARWIEPAELTVTHHALSHPLIPKSFAGVKLLQFSDLHLGHYYGLKRFYRIIGRINELGPDLVVFTGDLLHEANRYPHVNAVAEALAGVRAPLGKFCIYGNHDHGGYGTDIYRRLMERAGFRVLVNEHALVRRGHDAIAIAGSDDMMLGRPDWSKMTNGIPRATYTIALVHEPDGAIEARRFPIHVQLSGHSHGGQIQLPFIGPLITPPLSERYYEGFYHVGGLLLYVNRGLGTTRVPLRFFAPPELTVFSLTPG
>NZ_CP014335.1|WP_011230544.1|974632_975400_+|2,4-dienoyl-CoA-reductase
MNGKVIIVTGGSSGMGKYMAKRFVSDGANVVITGRRAEALEEAKREIAAPDGGKVLTIPMDVRNPEQVAHMVERTDAEFGRIDALINNAAGNFICPAEKLSINGWNSVINIVLNGTFYCSREVGNYWIQRGLKGNIINIVATYAWHAGAGVIHSASAKAGVLAMTRTLAVEWGKKYGFRVNAIAPGPIERTGGAERLWESEEAERMTLESVPLGRLGTPEEIAAVASFLLSDEAAYINGACITVDGGQWLNRRPF
>NZ_CP014335.1|WP_033012407.1|975616_976834_+|EAL-domain-containing-protein
MDALDVMANLPHVIPHYQPIFSADEHGVVGYEVLGRFQTETGPVSLGPFFHDETIPEEFRIEVDDVITKKALDYFLSLDDQTLLIFLNRDANLLMLDRGESFLQLLLSYEAKGLAPSRIVLEINEQHFKGDVDQLSHLLTYLRTYGVKVAVDNIAEHSIHLERIGVLSPDILKIDLRELRKTSVHQAYQEIVHSISLLARKIGATLLYEDIETSFQLQYAWRHGGRYYQGYYLAKPAPEVVPRDLLKDLLRQECHRFIQQEKKKLETLYQIAEQFQQRISALLGKYKKAADFNELISLLAGELDDVCFRIYVCDEDGFQQSGNMFKRGGRWELQPQYYMKNWSWRPYFLENIIRMRSRRRGILSDLYTDIETGETIRTYSYPIDERHYLFIDLSYSYLFEHDAHY

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Crispr_ID: NZ_CP014335_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014335_4

1853895-1854321

Orphan

Consensus_repeat	Method
GTTTCAATCCCTCATAGGTACGATAAAAAC	CRISPRCasFinder
GTTTCAATCCCTCATAGGTACGATAAAAAC	CRT
GTTTTTATCGTACCTATGAGGGATTGAAAC	PILER-CR

6 spacers

The CRISPR arrays of NZ_CP014335_4

>merge|NZ_CP014335|4|1853895-1854321|CRISPRCasFinder,CRT,PILER-CR
GCTTCAGTCCCCCACAGGTACGATAAAAACGTATTCCTGTACCACGTGATTTAACTGTTGAACAGATGTTTCAATCCCTCATAGGTACGATAAAAACTCGCGAGAGCGGTTTGAGCATGTATGGACCAATCAAGAGTTTCAATCCCTCATAGGTACGATAAAAACTTCGTGGCAAATCTCCAAAAACAGTGAGCTTTGAGAGTTTCAATCCCTCATAGGTACGATAAAAACCAACTGGCGCAAAGACCCGTTGTTTGAGCGAGAGCGTTTCAATCCCTCATAGGTACGATAAAAACTGATTGCATGTGAGGGTTATGAGGAACTGGATGCATGTTTCAATCCCTCATAGGTACGATAAAAACATTCATTCATCTTCCGATGGAATCGGACTTGCAGGGTTTCAATCCCTCATAGGTACGATAAAAAC

>NZ_CP014335|4|3|1853895-1854321|CRISPRCasFinder
GCTTCAGTCCCCCACAGGTACGATAAAAAC	GTATTCCTGTACCACGTGATTTAACTGTTGAACAGAT
GTTTCAATCCCTCATAGGTACGATAAAAAC	TCGCGAGAGCGGTTTGAGCATGTATGGACCAATCAAGA
GTTTCAATCCCTCATAGGTACGATAAAAAC	TTCGTGGCAAATCTCCAAAAACAGTGAGCTTTGAGA
GTTTCAATCCCTCATAGGTACGATAAAAAC	CAACTGGCGCAAAGACCCGTTGTTTGAGCGAGAGC
GTTTCAATCCCTCATAGGTACGATAAAAAC	TGATTGCATGTGAGGGTTATGAGGAACTGGATGCAT
GTTTCAATCCCTCATAGGTACGATAAAAAC	ATTCATTCATCTTCCGATGGAATCGGACTTGCAGG
GTTTCAATCCCTCATAGGTACGATAAAAAC

>NZ_CP014335|4|3|1853895-1854321|CRT
GCTTCAGTCCCCCACAGGTACGATAAAAAC	GTATTCCTGTACCACGTGATTTAACTGTTGAACAGAT
GTTTCAATCCCTCATAGGTACGATAAAAAC	TCGCGAGAGCGGTTTGAGCATGTATGGACCAATCAAGA
GTTTCAATCCCTCATAGGTACGATAAAAAC	TTCGTGGCAAATCTCCAAAAACAGTGAGCTTTGAGA
GTTTCAATCCCTCATAGGTACGATAAAAAC	CAACTGGCGCAAAGACCCGTTGTTTGAGCGAGAGC
GTTTCAATCCCTCATAGGTACGATAAAAAC	TGATTGCATGTGAGGGTTATGAGGAACTGGATGCAT
GTTTCAATCCCTCATAGGTACGATAAAAAC	ATTCATTCATCTTCCGATGGAATCGGACTTGCAGG
GTTTCAATCCCTCATAGGTACGATAAAAAC

>NZ_CP014335|4|3|1853962-1854321|PILER-CR
GTTTCAATCCCTCATAGGTACGATAAAAAC	TCGCGAGAGCGGTTTGAGCATGTATGGACCAATCAAGA
GTTTCAATCCCTCATAGGTACGATAAAAAC	TTCGTGGCAAATCTCCAAAAACAGTGAGCTTTGAGA
GTTTCAATCCCTCATAGGTACGATAAAAAC	CAACTGGCGCAAAGACCCGTTGTTTGAGCGAGAGC
GTTTCAATCCCTCATAGGTACGATAAAAAC	TGATTGCATGTGAGGGTTATGAGGAACTGGATGCAT
GTTTCAATCCCTCATAGGTACGATAAAAAC	ATTCATTCATCTTCCGATGGAATCGGACTTGCAGG
GTTTCAATCCCTCATAGGTACGATAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014335.1\|WP_020279061.1\|1855661_1856105_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NZ_CP014335.1\|WP_014196023.1\|1852864_1853794_-\|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl\|CDD\|273806
NZ_CP014335.1\|WP_062898671.1\|1844433_1845450_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP014335.1\|WP_023633751.1\|1851456_1852497_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP014335.1\|WP_013523968.1\|1860600_1860891_-\|UPF0175-family-protein	unknown	unknown	gnl\|CDD\|377095
NZ_CP014335.1\|WP_013523972.1\|1866527_1867475_-\|aldo/keto-reductase-family-protein	unknown	unknown	gnl\|CDD\|381300
NZ_CP014335.1\|WP_062898674.1\|1849397_1850924_-\|transporter	unknown	unknown	gnl\|CDD\|225870
NZ_CP014335.1\|WP_014196017.1\|1846967_1847654_-\|response-regulator	unknown	unknown	gnl\|CDD\|226931
NZ_CP014335.1\|WP_020279058.1\|1858513_1859962_-\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NZ_CP014335.1\|WP_062898675.1\|1856110_1858201_-\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CP014335.1\|WP_023633756.1\|1863047_1864235_-\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341473
NZ_CP014335.1\|WP_062898676.1\|1861385_1862846_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143404
NZ_CP014335.1\|WP_062898669.1\|1841365_1842715_-\|GntP-family-permease	unknown	unknown	gnl\|CDD\|308194
NZ_CP014335.1\|WP_014196024.1\|1854501_1855662_-\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NZ_CP014335.1\|WP_062898672.1\|1845970_1846906_-\|AEC-family-transporter	unknown	unknown	gnl\|CDD\|223751
NZ_CP014335.1\|WP_062898670.1\|1842871_1844416_-\|xylulokinase	unknown	unknown	gnl\|CDD\|130381
NZ_CP014335.1\|WP_021322439.1\|1860104_1860608_-\|DUF3368-domain-containing-protein	unknown	unknown	gnl\|CDD\|225269
NZ_CP014335.1\|WP_062898673.1\|1847726_1849325_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225827
NZ_CP014335.1\|WP_062898677.1\|1864429_1866139_-\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226350
NZ_CP014335.1\|WP_020279064.1\|1850937_1851402_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl\|CDD\|377815

Protein	Function_ID	Function_description	E-value
NZ_CP014335.1\|WP_020279061.1\|1855661_1856105_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	1.04008e-58
NZ_CP014335.1\|WP_014196023.1\|1852864_1853794_-\|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	4.88338e-11
NZ_CP014335.1\|WP_062898671.1\|1844433_1845450_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.38144e-106
NZ_CP014335.1\|WP_023633751.1\|1851456_1852497_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	6.18951e-94
NZ_CP014335.1\|WP_013523968.1\|1860600_1860891_-\|UPF0175-family-protein	gnl\|CDD\|377095	pfam03683, UPF0175, Uncharacterized protein family (UPF0175). This family contains small proteins of unknown function.	2.75843e-16
NZ_CP014335.1\|WP_013523972.1\|1866527_1867475_-\|aldo/keto-reductase-family-protein	gnl\|CDD\|381300	cd19074, Aldo_ket_red_shaker-like, Shaker potassium channel beta subunit family and similar proteins. This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.	0
NZ_CP014335.1\|WP_062898674.1\|1849397_1850924_-\|transporter	gnl\|CDD\|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP014335.1\|WP_014196017.1\|1846967_1847654_-\|response-regulator	gnl\|CDD\|226931	COG4565, CitB, Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms].	1.13943e-89
NZ_CP014335.1\|WP_020279058.1\|1858513_1859962_-\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NZ_CP014335.1\|WP_062898675.1\|1856110_1858201_-\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	3.55212e-66
NZ_CP014335.1\|WP_023633756.1\|1863047_1864235_-\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341473	cd08194, Fe-ADH-like, Iron-containing alcohol dehydrogenases-like. This family contains iron-containing alcohol dehydrogenase (Fe-ADH) most of which have not been characterized. Their specific function is unknown. The protein structure represents a dehydroquinate synthase-like fold and belongs to the alcohol dehydrogenase-like superfamily. It is distinct from other alcohol dehydrogenases which contain different protein domains. Alcohol dehydrogenase catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. Its activity requires iron ions.	0
NZ_CP014335.1\|WP_062898676.1\|1861385_1862846_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	gnl\|CDD\|143404	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2. Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.	0
NZ_CP014335.1\|WP_062898669.1\|1841365_1842715_-\|GntP-family-permease	gnl\|CDD\|308194	pfam02447, GntP_permease, GntP family permease. This is a family of integral membrane permeases that are involved in gluconate uptake. E. coli contains several members of this family including GntU, a low affinity transporter, and GntT, a high affinity transporter.	7.19092e-172
NZ_CP014335.1\|WP_014196024.1\|1854501_1855662_-\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NZ_CP014335.1\|WP_062898672.1\|1845970_1846906_-\|AEC-family-transporter	gnl\|CDD\|223751	COG0679, COG0679, Predicted permeases [General function prediction only].	1.6363e-31
NZ_CP014335.1\|WP_062898670.1\|1842871_1844416_-\|xylulokinase	gnl\|CDD\|130381	TIGR01314, gntK_FGGY, gluconate kinase, FGGY type. Gluconate is derived from glucose in two steps. This model describes one form of gluconate kinase, belonging to the FGGY family of carbohydrate kinases. Gluconate kinase phosphoryates gluconate for entry into the Entner-Douderoff pathway. [Energy metabolism, Sugars].	0
NZ_CP014335.1\|WP_021322439.1\|1860104_1860608_-\|DUF3368-domain-containing-protein	gnl\|CDD\|225269	COG2405, COG2405, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only].	1.46092e-32
NZ_CP014335.1\|WP_062898673.1\|1847726_1849325_-\|sensor-histidine-kinase	gnl\|CDD\|225827	COG3290, CitA, Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms].	0
NZ_CP014335.1\|WP_062898677.1\|1864429_1866139_-\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|226350	COG3829, RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms].	2.41035e-179
NZ_CP014335.1\|WP_020279064.1\|1850937_1851402_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	5.51093e-13

>NZ_CP014335.1|WP_014196023.1|1852864_1853794_-|Rpn-family-recombination-promoting-nuclease/putative-transposase
MAIDHDRLFKELIQTFFEEFLLLFFPDMHEHIDFSHLSFLSEELFTDVTAGEKYRVDLLVETKLKGEDGLIIVHVENQSYVQPSFPERMFIYFSRLFEKYRTRIVPIAVFSHDTLREEPSVFSIEFPFGDVLQFRFFPVELRKKHWRDYIRHDNPIAAALLGKMGYTESEKIELKKEFLRMLVRLELDEARQRLLLGFFETYVKLSEEEEQQLQREVKEMETTEKEKMLELIISYEQRGRKQGLEEGIKRGIEQGIKQGMKQGMKQGMKQGMKQLIRNMARKGMKVEDIARLVDLPEQDVWELLEEQGN
>NZ_CP014335.1|WP_023633751.1|1851456_1852497_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MKKKRWWGLLAAGMMTLALAACGGNESAGSKPSGSNSGSSASNYPTKPITIVAPSGAGGGWDLTARAITKVLDETGLIKQTMTVENKPGGGGAVFMAEYATQDVKNDYKLFVNSPPIIINNLKKEGNSPFGYKDTTPLAQLTKDFGAIVVKADSKFQTLTDLLNTIKQDPKSVTVAGGSAPGSMDHLVAILPIYKSGIDPKSVKYVSYDGGGEAMAALLGGNADVIATDASSVGEYLKAGKVRVLAVSAPERLGGVLKDVPTLKELGIDAEFTIWRGVFGPKQMSREAKAFWEETLKKLSEHEKWKEELQKQGWAAEYRNSDEFTKFLQEQEQQIGDLLKSLGMHK
>NZ_CP014335.1|WP_020279064.1|1850937_1851402_-|tripartite-tricarboxylate-transporter-TctB-family-protein
MNKTADRIAAVAFLAVGSLFMAESLRLSKSAYGSAVGPNVFPFLLGLVLALLSIKLLFETRGYKDYKDSVGEKPPRQYKKFLIIFIAAVFYATLLETVGYVITTFLFLVIGFQTMERGALWKSIAIAAGFSLGVYGLYVKLLQGTLPSWPIWFQ
>NZ_CP014335.1|WP_062898674.1|1849397_1850924_-|transporter
MSTLSFLLDGFQTALQPHNLLFAFIGVLIGTAVGVLPGIGPMSGVALLIPVTASMTSGLSPEQAAASSIILLAGVYYGAMYGGSTTSILLNTPGESSSVVTTLDGYQMARQGRAGAALAIAAIGSFVAGIVSLIGLVLLAQPLSNVALKFGPAEYFSLMLLGLAAVSGLAGKSMTKAWIMTVFGLLISTIGLDNVSGVARFTYDISYLYGGLEFLTVAVGLFALGEVFKSILHHETNDGDIAKIGRVLPTKADLKESAGPIARGSLLGFFIGVLPGAGATLASFFSYILEKKVSKHPEKFGQGTIAGVAAPESANNGASGGAMIPLLTLGIPGSGTTAILMGALIMYNVQPGPLLFDEHPAVAWGLIASMFIGNVMLLILNMPLVKVFAKIIQTPTKYLLPLIIAISVFGVYAVQVTTFDVFLLLAFGLLGYWLAEHDYPLAPLVLGLVLGPMIENNMRRALTASNGDYLVFFEKPISLVLLVIAFLWIAVPFVMKLRGKSVVINEDM
>NZ_CP014335.1|WP_062898673.1|1847726_1849325_-|sensor-histidine-kinase
MKLQTRLMVIICSLLLLVIVVLTFLFQHMFATTLKQQIGMRALNVAETVASTPLVREAFRDPNPSVRLQPFAEHIRRKTGAEYVVIGNRKGIRYAHPLPDRIGKHMVGGDNGEVLKGKAIISEAVGSLGPAIRGKAPIFDENGHVIGIVSVGFLLEDIQRTVWSYRMKMFLFSVFALFLGAVGAMAIASTVKKSIHGLEPEEIGLLYQEKQAILEAIREGIVAINQEGTITMVNQTALKLLGYENERGVLGMPILQLIPHSRLPEVIRTGQAEFDDEMVLGEETVIANRIPIKDKTGRVIGAVSTFRNKSELYRLTKELSQLRVYADALRAQTHEFSNKLYLISGLIQLESYEEALELITKETNLQQNIIRFVMKEIPDSIIGGLLIDKFNRAHELKITFEIDRESSFRDVPPWIDRDHLVTIIGNLLDNAMEAVLHNGKEEKRVTIFLTDLGDDLIIEVEDNGLGVDPDVAERIYDRGFSTKANGLRGYGLDLVRKALAMLGGQITYQSKQGEGTVFTVIIPKRSGRANPC
>NZ_CP014335.1|WP_014196017.1|1846967_1847654_-|response-regulator
MIRVLIIEDDRRIAEINRRFVEKVNGYEVVGIATNAEEARELTEVLQPDVLLLDVYFPDMNGLSFLKWVRERFSNIDIIMITAAREVDALKQALHGGVFDYIIKPIMFDRFAETLHRYKEYYDKMQQWMKEKEWIDQEDVDKLIGREAPVRDQPMLPKGIQPLTLEKVLMVVKRCQDGVTAEEVGRQIGTSRTTARRYLEYLVSTGQVLADIVYGSVGRPERIYKKRG
>NZ_CP014335.1|WP_062898672.1|1845970_1846906_-|AEC-family-transporter
MDIFVSILLQVMIPMLLIVGLGAGFHRFFRLDLNTLSKLNMYVLLPAVAFINVYDSELNGKVLAAILGFLLLQNGGLMVLSRIMAKLFKLERSMAAVFQNTVVLNNSGNFGIPVSQLVFHQHPLGATIQIIVTIFQNFLTNTYGVYQFVSGNGKSGKWAAEIWKNPVLHALLFGVVCRWLHVPIPSFLWTPLRRVADAFLAIALFTLGAQIAYARFNALPPLVYASVFGRLVLSPLLAASLIFLLGIDGVTAQALLIASSYPCSRNTALYALEYDCHPDYAAQAVLVSTLLSAITVTGVVYAARLLFPIAG
>NZ_CP014335.1|WP_062898671.1|1844433_1845450_-|LacI-family-DNA-binding-transcriptional-regulator
MKKVTMADVAKLANVSKSTVSQYLNKRYEYMSEETRKRIAQAIEELGYQPNVIARSLKQKTTATIGVIVFNMLHMLTTQVLHAIEEECQKRGFQVIVCNSGDDSEKEKKYVDMLLAKQVDGLIVFPTGKNEEVYRRLVEERFPLVFVDRMVPGVEADSVLLDNAGAAEMAVQYFASYGYDRIAIVTPPLVPYNVPRMERFEGFRAAMEKRGFEVGDQNVIAAEPAALPGELKKRFMESERPNALFAINDLTLMGVLRFVKETGIRMPDELAIINIDDVPFADIYTPALTTIAQPTFAMGKKAAERVFEQMDSNHADSPRVFRFSPVLMERTAIRREKA
>NZ_CP014335.1|WP_062898670.1|1842871_1844416_-|xylulokinase
MAIHGDVVIGIDIGTTSTKAVVFDEQGRVLASHAIDYPIIQPHPGFAEQDPEELFAAVIQAVGAVTIRHGIRPEQVKAMGLSAAMHSIMALDGSGRPLTRLMIWADNRSVAQAERLLKEQNGLDIYRRTGTPIHPMSPLPKLLWLKEKQPDVFRQARWFVSVKDYVLYRLYGDYIADHSLASATGLFRLDTLDWDEGVLSFLGISREQLPRLVPAIHILQGMKKEWADKMGVSADVPVVIGASDGVLANVGVGAVLPGEAAITIGTSGAVRTIATKPTTDEKGRTFCYALTPGYWVVGGPTNNGGILLRWLRDEFGAQEREVAKKLGMDPYDLLTKYAERVPPGSEGLVFLPFLSGERAPYWNANARGTFFGLGLHHKREHFIRAVMEGVCFSILSVALAIRDATGPMSEIRVSGGFAKSPFWRQMLADMLGKPLIVPQTHEASALGAAAVALHALGELPSLEMVKPWIGTMARHEPNEAHTLIYAELFDLYARLYERLKEEFDIIAAFQRRNG
>NZ_CP014335.1|WP_062898669.1|1841365_1842715_-|GntP-family-permease
MGIAIVIAAIIVLLLLITAVKMHPFVALILVSVGVGLAMGMPLVAPSPETPGIIDSIKAGLGNTLGFLAIVLALGTMLGKMMAESGGAERIAKTLIDRFGQKRVHWAMMVVAFLVGIPVFFQVGFVLLIPLVFTIAMETGISLVTIGIPLVAGLSVVHGLVPPHPAAMAAVGIFQADVGKTILYSIIVGLPTAIIAGPLYGKWIGSRLHKTVPAEIAEQLVQHKEAREFPGFGNTLFTILLPVILMLIASVANVTLDQKSEAAKVLRFIGDPIVALLIATVYSFFSLGYARGFNRDAVLKFANDCLGPVANILLVIGAGGAFNKVLLDSGIGEQIAEVAKHSHFSPLLLGWGIAALIRVATGSATVSMMTAAGIVAPIAATMPGTNMELLVLATGAGSLILSHVNDSGFWMIKEYFGMTVKETLMTWTVMETIISVVAFVFILLLNMVL
>NZ_CP014335.1|WP_014196024.1|1854501_1855662_-|mannitol-1-phosphate-5-dehydrogenase
MRAVHFGAGNIGRGFIGSLLAASGYDVVFVDVNEQIVRLLKERGEYRVIVAGERREEQWVRGVSALNSQTEREAVIEAIADADLVTTAVGPHILPAIAPVIAAGLERRFTVHQKPLHVIACENMIGGTETLKMHVFAHLSTAGQQLADENVGFLNCAVDRIVPNQTNDDPLAVTVEPFFEWTIETRNVIGTVPPIQGAHFVADLEPYIERKLFTVNTGHALAAYLGYLRNYKTVQEAMNDEGIRLNVEQALSESGAVLLKKHGWHEEEHRSYIKTTIGRFTNPSLSDDIVRVARSPIRKLGPNDRLIAPATQYCTLFGSVPAGLAKGIAALLRFDDASDAEAAALQQTIAHHGIEGALRQYAGLESAHPLVAAVREEYGRMEKNKS
>NZ_CP014335.1|WP_020279061.1|1855661_1856105_-|PTS-sugar-transporter-subunit-IIA
MLTHSILNKENIVLNAQPKTKEEAIRLAGEVLVKQGYVAPAYVDAMLEREELTSTYIGNNVAIPHGTEAAKALVKQSGISIVQVPDGVDFGGGNMATIVIGIAGKDGKHLDILSKLALVCAEADNVAAMANAKTAEEILALLHEVNG
>NZ_CP014335.1|WP_062898675.1|1856110_1858201_-|BglG-family-transcription-antiterminator
MYVSARERKLLERLLADDRDITVGELAEELNVSARTVHRDLQGLESVFRRYGLKLAKRAGVGIRLVGEEEKKQALAAELFRLSHHEYTPEERQLMILIALLEANEPVKLVTLAHDLNVTVATVSLDLDKLEQTVEAYGLSLIRKRGYGVELAGSESAKRRLMSDLLFRHVDEHEFLALMKETIQKRTDAPLDTVAEKLLGLVDRKKLAVIEQQIEQVKEKLPFTMADSSYIAFVVHLALAIERIKRGEAIHFDPRDLQALQATKEYEIAEVLAESLKRAFGIDIPNEEIGYMTMHLMGAKWRSRQGMVMEEPSLAVGMKAQQLIRFVSDKIGVDLSADRTLYEDLVVHLKPALYRLEHGMGVANPLLDPIKQDYAELFAIVADGARQLFGGIPIPDEEIGYLVLHFAAALMREKKGWRVLVICSSGLGTAKILATRLKKEIPDIVSLEQASAFEWKGKDVSAYDLVISTVPLPEEYGPHIVVSPMLTEEEARKIRECLERKSAAEKRMRKESTARRNRPAIDTMKAVRRISETIVHILDGFSLEVVKRRSVHEILTDACRRLERSGVIVDADVVIEELRRRESLGGLGVPGTTLALYHARSFAVLRPSLTMYRLDSPQTVAGMDGEPMEINTVVLLLGPADADEEVLSVLSHVSTLLVKNEQSAATLAYGGEDEVYSLISGHLEQFFDDYWISMKE
>NZ_CP014335.1|WP_020279058.1|1858513_1859962_-|PTS-mannitol-transporter-subunit-IICB
MTHTTGNETGFRVKIQRFGGYLSGMIMPNIGAFIAWGLITALFIPTGWLPNETFAKLVGPMITYLLPLLIGYTGGKMVYDVRGGVVGATATMGVVVGSEIPMFLGAMIMGPLGGYVIKKVDGLFQGKVKQGFEMLVNNFSAGIVGGVLTLLAFKGVGPVISVISKTLAAGVEKIIDWHLLPLANLFIEPGKVLFLNNAINHGILSPLGVEQAAKTGKSILFLLETNPGPGLGILLAYWLFGKGMAKQSAPGAVIIHFLGGIHEIYFPYILMRPILILAAMAGGVSGVFTFTVLHAGLVAVPSPGSIFALLAMTPKGNYFGVLAGVFVAAAVSFLVASIFLKAAKQSEEEEELTKATEKMEQLKGKKSQVAAALQQKEAASAAVAQAVPGRVKKIVFACDAGMGSSAMGASILRNKVQKAGLDIEVTNTAINQLPADADIVVTHQNLTDRAKAKLPNAYHVSVENFLNSPKYDELIEQLKKNA
>NZ_CP014335.1|WP_021322439.1|1860104_1860608_-|DUF3368-domain-containing-protein
MSRVTVNSTPIIGLSIVGQLTLLSELFDEVYVPEAVYQEIVHNHAPRHYGKEELKRLVSEGVFRLYHVKNRSLVESLYGKFHAGELEVIIGAKELGAQVVVIDEHAARSLSKQFLLRPIGTIGVLILGKKNRKIAEVKPLLDTLLENGFYLSQRLYREALSLAEETP
>NZ_CP014335.1|WP_013523968.1|1860600_1860891_-|UPF0175-family-protein
MDYFQVNLPKEFLPAINELEGNTVEAKIKLSLAIGLFVGKQVTLAKAAELAGKSLGEFIDVLRSKAIPWMEYTEEHIKDDWDTVQKLSKENRDHNE
>NZ_CP014335.1|WP_062898676.1|1861385_1862846_-|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase
MSSVTETKTLKNFIGGQWVASTSGKEEIVPNPATGEVLAKVPLSSREELDAAVAAAKEAFREWRKVPVPRRARILFRYQQLLVEHWDELARLVTLENGKVYEDAYGEVQRGIECVEFAAGIPTLMMGQQLPDIATDIESGMYRYPLGVVAGITPFNFPMMVPCWMFPLAIACGNTFVLKPSERTPMLANRLAELFTEAGLPPGVLNIVHGAHEVVNGILEHKDIKAVSFVGSQPVAEYVYKTAAAHGKRVQALAGAKNHSIVMPDADLDMAVTNIINAAFGSAGERCMACSVVVAVGDIADELVERLKEAADRIQIGNGLDKGVFLGPVIRESHKERTIKYIEIGEKEGALLVRDGRRDSATSGKGYFIGPTIFDHVKPGMAIWTDEIFAPVLSVVRARDLDEAIEIANRSEFANGACIYTDSAKAIRQFREEIDAGMLGVNVAVPAPMAFFPFSGYKNSFYGDLHANGRDGVEFYTRKKMVTARY
>NZ_CP014335.1|WP_023633756.1|1863047_1864235_-|iron-containing-alcohol-dehydrogenase
MYELLVPSRVVYGRNTFAEVGPQAKALGTKALIVSDPVMEKIGLVARCEQYLQQVGMTFAKYTGVDTEPTDVHVKEALDVCRSEQCDVIIALGGGSSIDAAKAVAVMITNEGTISDYVGNQKRFTEKPLPLIAIPTTAGTGSEVTKVTVIIDTKTDVKMMISQPALLPAVAIVDPLLTVSCPPSVTAATGVDALCHAIEAYISRRAHPVTDVLALSAIEAIIGHLRRAYENGQDIEAREKMAIAAMKAGMAFSNASVTLVHGMSRPIGALFHVPHGVSNAMLLPGVLEFTKDSAIERLAVIARIIKPPLKDVSDTEAAEALVEEVKQLCRDLHIPNMKTWGIDKTAFDKVVDKMAADALASGSPANNPKVPTHEEIVALYHYCYDYQYDTKTVSS
>NZ_CP014335.1|WP_062898677.1|1864429_1866139_-|sigma-54-interacting-transcriptional-regulator
MASDCSALPTVVCRQTLQEVMQRMAARGLESVNVIDEHGRTVGRCTWRMMLRAAADGLDRSMPIGEVLMAFSDKWETKQEGVCAAMPMSESDSKATNELERLRRELEETHRLAETMKTVLDAAYEGVVVVDEGGVVREINRAYCQFLGIRREEAIGKHVTEVIENTRLHICVQSGIPERGYIQKIYGQPMVVHRIPIWRDGKVIGAIGMLIFQGVSEVYEIFRRLQELSREASRKEKKEAKPQETAASAPKGIERIIGRHPSIAAVKQMIRRAARVPSTVLITGESGTGKEVVARAIHEAGPHADGPFVSVNCAAIPESLLEAELFGYEDGAFTGAKKGGKPGKFQLAHGGTLFLDEIGDMPLAMQAKILRVLEEKKVEKVGGLYETKVDVRIIAATNKPLEEMVRNGTFREDLFYRLNIIRIHLPPLRERKTDIPALLAYHMDRMCRQFGVALKSFTKEAMEVLVHYSWPGNVRELVNVVEWLISMVEGEKVEREHLPSYLSTVQPAASSLPNGGVKMADRWKEMVYQSERERIAAALVAAGGNKAEAARRLGIHRSTLYEKLKKYGL
>NZ_CP014335.1|WP_013523972.1|1866527_1867475_-|aldo/keto-reductase-family-protein
MKYRKLGRTGLKVSEISLGSWLTYGNSVEKETAIRVIDKAYELGINSFDTANVYARGEAEKIVGEALRKYPRESYVIATKVFWPMGDGPNDRGLSRKHVFEQLHASLKRLQLDYVDIYYCHRYDKETPVDETLRTIDDLVRQGKVLYVGVSEWTAQQIQEALGVADRYLLDRIVVNQPQYNMFHRYIEKEVIPVCEQNGISQIVFSPLAQGVLTGKYKRGQALPADSRAADPRANTFIQGLLNDEVLTKVEQLEKIAAELGITLSQLALAWVLRQPNVASALIGASRPEQVEENVKAVDVVLSEDVLEKIEGILA

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Crispr_ID: NZ_CP014335_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014335_5

2438158-2438242

Orphan

Consensus_repeat	Method
TTGGCTTGGTATTGGCGCGTTGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP014335_5

>merge|NZ_CP014335|5|2438158-2438242|CRISPRCasFinder
TTGGCTTGGTATTGGCGCGTTGCCGCCGTTGTCACCGGGGCTTGGCGGTGTGTCGCTGTTTTGGCTTGGTATCGGCGCGTTGCCG

>NZ_CP014335|5|4|2438158-2438242|CRISPRCasFinder
TTGGCTTGGTATTGGCGCGTTGCCG	CCGTTGTCACCGGGGCTTGGCGGTGTGTCGCTGTT
TTGGCTTGGTATCGGCGCGTTGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014335.1\|WP_062898830.1\|2435386_2435668_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_050437069.1\|2444072_2444285_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_025949292.1\|2441224_2441653_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_023634630.1\|2439223_2439415_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_050437068.1\|2433179_2433545_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_023634628.1\|2439691_2439850_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_162924030.1\|2439861_2440002_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_047752754.1\|2435669_2436143_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_156484085.1\|2435252_2435396_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_047752757.1\|2434504_2434852_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_062898833.1\|2441770_2444062_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235927
NZ_CP014335.1\|WP_025949282.1\|2433541_2433880_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_025949280.1\|2432944_2433196_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_167552188.1\|2440134_2440311_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_025949295.1\|2444536_2444731_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_047752758.1\|2433848_2434505_-\|ATPase	unknown	unknown	unknown
NZ_CP014335.1\|WP_062898832.1\|2439471_2439687_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_047752756.1\|2434851_2435253_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_075261363.1\|2441032_2441209_-\|Fur-regulated-basic-protein-FbpA	unknown	unknown	unknown
NZ_CP014335.1\|WP_156484086.1\|2436299_2438075_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214495

>NZ_CP014335.1|WP_156484086.1|2436299_2438075_-|hypothetical-protein
MRVRITFIVCIFFISFSFLNSAFAAVTSGYVSPVVINSVSPVAGYNPENSVDSNLTSYTNLGGNGYIKYLIPSGSNSMKIHLRTTNYPVNQYLGSYRIVFSNSQGVVWDSGNIKIYTTSLIAYDFAIPDKATEVTVYSTSYADYFPLLVYEVEMTVPIDKTPPHEVTNLVTTSSTTTILLTFNKPTDSDYTGTRLYVNGVLVKTLGSTTTSYRLTELKPNTTYNIRITTFDTSNNESEGITTSVKTPPPPDVANLILSPSPYSIFAKWINPDDPDGLGFIGNDLYLNEKLITSLDKNTTTYTFTDLSPNTSYTVKIVSKYNGGYSSSGQTATAKTTIPIEDITDLQADAKYDRVKLSWKLPDSEFFSHVKIYRKKIEQQSFWDQLFGATAVSAATTSDGYTPMFETNGTYWTDLTVTPDTTYSYKVTSVNIEGNESQGVTIETKTPSEPAPVLTGVATTQNENGDYIVTWTSPTKGSVKVLIGGKSYTVVDAASQQVMIKKEDMKTDFFGGYDAKLVPVGQFGTEGQAVQVPAVGKKIEFPITFDDFMKTVVNILSWAAPLILVLFVFIFWRPFIAFLRKTIFVKGGRMKS
>NZ_CP014335.1|WP_047752754.1|2435669_2436143_-|hypothetical-protein
MIFVPLVVSGILGDAFGKLFDVIWSVIKWIGRLLKKLFQGLIDLIVGFFEVIYALIDGMLYFLYKIGVLAVKLFLLFFELAKMIVSLFVGFAKTLASLVYVPRGGSGNGYSEMLGKIFAAMQPLKLEPIAYILLFILWMFTAVAAIKLLSSIRVGGD
>NZ_CP014335.1|WP_062898830.1|2435386_2435668_-|hypothetical-protein
MNIKEAIHSFIDKIFNPPITFLDMGIEKLRAVGQLTAQGLNVGKYLSVFGDLPTAWQLVVSSALASVVILGSLLIFRSVMRLYYSLKEGVKWW
>NZ_CP014335.1|WP_156484085.1|2435252_2435396_-|hypothetical-protein
MVVDAFFYMFTLGAGAAAGVGVIAFLGWKIVQFSNRKAKKQQRRAVI
>NZ_CP014335.1|WP_047752756.1|2434851_2435253_-|hypothetical-protein
MGLLKKKEKDEFFPGTNDILIVFDDEQKTSDIQRIDEIRDGAVYVTGKYKVPIHDCEITTGPEGRHFFYRAPSRSVQETQRLAELEKSIVLRQITSYRPPEPPSQLDMTKILLFGLVFFAFIIIGISSCGGGS
>NZ_CP014335.1|WP_047752757.1|2434504_2434852_-|hypothetical-protein
MQSNAEKLQSVISDDLFPQVQHISDVKQVLEEMTTKAQELQEWQIKAILLLESLSRNKYLHGKTDPYREIINFIMQGKVLVADPQYYIDTIEALIPKPPKPVIVAPNGVEKGGKR
>NZ_CP014335.1|WP_047752758.1|2433848_2434505_-|ATPase
MAHHFFIQGPLGAGKTLMMSLLAHHWREKVRARGGDIQLFSNYGLKDSIPLEHYTDWYKVAEAQGSICCWDEAQMAFSNRKWSKYGATIATEVMMFTRKMKSVQIYCSPSINNVDSRIRQIVEVLINVRKIGDRGFAIHFTDYQTGEFMHKQFLPMWKAKKIFKLGLYDTDTMVLGFPLPSTEREGNEFFRTLEEIHEKSRQTVRRAARELLTGAGAL
>NZ_CP014335.1|WP_025949282.1|2433541_2433880_-|hypothetical-protein
MNYSLVPEHYKDKDPRTLLYHFPSIPVVKFAKITQKFYFFKQLEIAQDIVNRMGYILLPSACMHWERVKQFADRRIRIGRNSFFMMRPNELTESERRKLQEYLDEIKKGEKS
>NZ_CP014335.1|WP_050437068.1|2433179_2433545_-|hypothetical-protein
MKIQLTNTEVGMLLIHMGIMRKEIKKALKRNYSFFEAKRQLACYDSIIDLLGRVVDDTKKLCDIEFSDEQKEMLASFIYSYTTIIKQEAGREKIDASDILQAFEKIAARLEGGRHAYAETI
>NZ_CP014335.1|WP_025949280.1|2432944_2433196_-|hypothetical-protein
MLKLFKQLDFWLSLVMALCGIALSYIIVPYLFPDVMEGMFATCLLTGLFIGEFLGETKHLMKAIINERIATKEHIHEIRPDNR
>NZ_CP014335.1|WP_023634630.1|2439223_2439415_-|hypothetical-protein
MPALGAAIDLSGLTLPFSVSDLIGSVNSLISWVGPFVLLALALGFAPKIISFIKSIFGRATAK
>NZ_CP014335.1|WP_062898832.1|2439471_2439687_-|hypothetical-protein
MPQFQTFFTPARLDEFWYYVKWILFYAAPAIMIMAAAGAISLLILVIKKSFANENEINRQDETDDYEIRRY
>NZ_CP014335.1|WP_023634628.1|2439691_2439850_-|hypothetical-protein
MSSIGNVFDWSFFWGVFGFLLKTVAPFVMLVVAIVAVGMLLHGVIVAIRSRS
>NZ_CP014335.1|WP_162924030.1|2439861_2440002_-|hypothetical-protein
MVTTGTLVAYAFKVVFGNGDVITALASWAIFLTFCFVATAIYQAMR
>NZ_CP014335.1|WP_167552188.1|2440134_2440311_-|hypothetical-protein
MNGQSSNITYVEMRGHTVIETKEGNIVVIHEITLGDVVISVILAAMLIFMVLERFMRR
>NZ_CP014335.1|WP_075261363.1|2441032_2441209_-|Fur-regulated-basic-protein-FbpA
MTAFKLYLREAIEQVRVKRIEQLQAAGYRKTVEGRLLDELTLSELNHEYHCLKEQKGK
>NZ_CP014335.1|WP_025949292.1|2441224_2441653_-|hypothetical-protein
MLYNIFYRLENLNIQIKVKNNKISLLYKDGSLPMDLKKQIQQHKEEIKRRLEENEQARRYGFLIYAYGELYEFRYGKGSYLFIEREGNKAIVWRGSYIHGDPRPYRIKVLANRVPFHHALAEAVGFIEWLKRQEGRANIYSL
>NZ_CP014335.1|WP_062898833.1|2441770_2444062_-|DNA-primase
MQAALDFQMSLERLFPSAKKPLKIIRLIGYSRMNNESDPQKAYSVAKRPCMKGWQDLNRPGMTEGEIRAWLRQKGWTGLVIPDGYDVIDIDEQEEGEMLLKALLREGYKFHAIRTIRGFQFFFRSTGKIKGQDATVLMAGGFVGDYRLSGRGQVVLPSENTGGREWVHIADGELSPMPIFFERLKKIDKAQRPFPIPMPEGGRNNALFSHCCRLVEFGYTQEQVREIASFLNRYFFLPPLDQREFANTLNSALKHEPSGTDYFAPLPMPSPSRKEGKKFNLTEMGNAERLVARNGQNLRYCVEFEEWLIWDGKTWVEDKKKQIERIAIRTFREMYAEVAQEENNDARNELLKWAKASEKSSVFLNSIARAEAMLPISQDELNKDKFLLNCANGVVDLRTGELLPHDRKYMMTKNTHVNYDPNAKCPTWIAFLESIFRDGDEVKRDIIEFLQKAIGYALTGDISEQVVFFLWGTGRNGKSTFINTVKALLGDYAKQTNSNTFTAKMNDSGINNDIARLHGARFVSAVESEDGQRLSESLIKQLTGGEPITARFLRKEFFEFVPEFKIFFTTNHKPIIKGDDEGIWRRIRLVPFTYTIPKEQVDKHLPEKLLNELPGILRWAVEGCLKWQKEGLGEPDEVKNATDEYKEEMDLLSNFLNDCCVIHPGAKVQLNELYKEYISWCEENSEIPLKKQKFSARLVLRGFEKRKSTGNKTFFFGIGLSAESYKVTSSYSNSGKSPIGDNFEEIPKNKSLEVTSNLVEEEI
>NZ_CP014335.1|WP_050437069.1|2444072_2444285_-|hypothetical-protein
MVTKQKADPMQKYVPIVMRWIEEAFDMTAIQVEDFSVFPAGKLIRDENGHTMVVFYDVWTDQVKYTFPKK
>NZ_CP014335.1|WP_025949295.1|2444536_2444731_-|hypothetical-protein
MRVKISLIVEEKEHVNRAIGCIDHMLDAVMTKDYKAARQVIKSFESVLDKLQEIEMKKARNMGL

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Crispr_ID: NZ_CP014335_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014335_6

2772128-2772226

Orphan

Consensus_repeat	Method
AGTCTTGCTTAATCATATGGCAGAGTGCAAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP014335_6

>merge|NZ_CP014335|6|2772128-2772226|CRISPRCasFinder
AGTCTTGCTTAATCATATGGCAGAGTGCAAACATTGAAGATAGCGGGAAACAGATTACAAGTGTTCGAGTCTTGCTTAATCATATGGCAGAGTGCAAAC

>NZ_CP014335|6|5|2772128-2772226|CRISPRCasFinder
AGTCTTGCTTAATCATATGGCAGAGTGCAAAC	ATTGAAGATAGCGGGAAACAGATTACAAGTGTTCG
AGTCTTGCTTAATCATATGGCAGAGTGCAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014335.1\|WP_062898889.1\|2774964_2775972_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223787
NZ_CP014335.1\|WP_062898888.1\|2773884_2774673_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP014335.1\|WP_011232318.1\|2764271_2764859_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|377744
NZ_CP014335.1\|WP_011232316.1\|2763539_2763704_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_011232315.1\|2762129_2763329_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NZ_CP014335.1\|WP_011232331.1\|2778216_2778549_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366282
NZ_CP014335.1\|WP_021322704.1\|2766925_2768137_-\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NZ_CP014335.1\|WP_062898887.1\|2772437_2773340_-\|transposase	unknown	unknown	gnl\|CDD\|273806
NZ_CP014335.1\|WP_011232317.1\|2763722_2763986_-\|YtzC-family-protein	unknown	unknown	gnl\|CDD\|287677
NZ_CP014335.1\|WP_011232329.1\|2776762_2777572_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NZ_CP014335.1\|WP_011232330.1\|2777690_2778158_-\|nucleoside-triphosphatase-YtkD	unknown	unknown	gnl\|CDD\|131752
NZ_CP014335.1\|WP_062898886.1\|2768599_2770186_+\|phosphoenolpyruvate-carboxykinase-(ATP)	unknown	unknown	gnl\|CDD\|236471
NZ_CP014335.1\|WP_011232320.1\|2766354_2766903_+\|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl\|CDD\|100051
NZ_CP014335.1\|WP_033845326.1\|2770831_2772079_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP014335.1\|WP_014196600.1\|2779159_2779600_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NZ_CP014335.1\|WP_013524459.1\|2778610_2779006_-\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377457
NZ_CP014335.1\|WP_033009830.1\|2773573_2773816_-\|DUF2584-domain-containing-protein	unknown	unknown	gnl\|CDD\|371230
NZ_CP014335.1\|WP_025039215.1\|2764906_2765989_-\|tetraprenyl-beta-curcumene-synthase-family-protein	unknown	unknown	gnl\|CDD\|378492
NZ_CP014335.1\|WP_062898890.1\|2775987_2776779_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213260
NZ_CP014335.1\|WP_062898885.1\|2759323_2761741_-\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743

Protein	Function_ID	Function_description	E-value
NZ_CP014335.1\|WP_062898889.1\|2774964_2775972_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	4.44624e-46
NZ_CP014335.1\|WP_062898888.1\|2773884_2774673_-\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	2.64665e-51
NZ_CP014335.1\|WP_011232318.1\|2764271_2764859_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|377744	pfam06962, rRNA_methylase, Putative rRNA methylase. This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.	9.37639e-73
NZ_CP014335.1\|WP_011232315.1\|2762129_2763329_-\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.46322e-79
NZ_CP014335.1\|WP_011232331.1\|2778216_2778549_-\|hypothetical-protein	gnl\|CDD\|366282	pfam00750, tRNA-synt_1d, tRNA synthetases class I (R). Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only arginyl tRNA synthetase.	0.00614322
NZ_CP014335.1\|WP_021322704.1\|2766925_2768137_-\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NZ_CP014335.1\|WP_062898887.1\|2772437_2773340_-\|transposase	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	8.5105e-16
NZ_CP014335.1\|WP_011232317.1\|2763722_2763986_-\|YtzC-family-protein	gnl\|CDD\|287677	pfam10732, DUF2524, Protein of unknown function (DUF2524). This family of proteins with unknown function appears to be restricted to Bacillaceae bacteria.	2.29592e-27
NZ_CP014335.1\|WP_011232329.1\|2776762_2777572_+\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	3.72348e-65
NZ_CP014335.1\|WP_011232330.1\|2777690_2778158_-\|nucleoside-triphosphatase-YtkD	gnl\|CDD\|131752	TIGR02705, conserved_hypothetical_protein, nucleoside triphosphatase YtkD. The functional assignment to the proteins of this family is contentious, with papers disagreeing in both interpretation and enzyme assay results. This protein belongs to the nudix family and shares some sequence identity with E. coli MutT but appears not to be functionally interchangeable with it. [DNA metabolism, DNA replication, recombination, and repair].	2.59219e-93
NZ_CP014335.1\|WP_062898886.1\|2768599_2770186_+\|phosphoenolpyruvate-carboxykinase-(ATP)	gnl\|CDD\|236471	PRK09344, PRK09344, phosphoenolpyruvate carboxykinase.	0
NZ_CP014335.1\|WP_011232320.1\|2766354_2766903_+\|gamma-carbonic-anhydrase-family-protein	gnl\|CDD\|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	1.73666e-79
NZ_CP014335.1\|WP_033845326.1\|2770831_2772079_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.03377e-46
NZ_CP014335.1\|WP_014196600.1\|2779159_2779600_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	9.01076e-66
NZ_CP014335.1\|WP_013524459.1\|2778610_2779006_-\|phage-holin-family-protein	gnl\|CDD\|377457	pfam05105, Phage_holin_4_1, Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.	6.86496e-38
NZ_CP014335.1\|WP_033009830.1\|2773573_2773816_-\|DUF2584-domain-containing-protein	gnl\|CDD\|371230	pfam10763, DUF2584, Protein of unknown function (DUF2584). This bacterial family of proteins have no known function.	1.19746e-38
NZ_CP014335.1\|WP_025039215.1\|2764906_2765989_-\|tetraprenyl-beta-curcumene-synthase-family-protein	gnl\|CDD\|378492	pfam10776, DUF2600, Protein of unknown function (DUF2600). This is a bacterial family of proteins. Some members in the family are annotated as YtpB however currently no function is known.	0
NZ_CP014335.1\|WP_062898890.1\|2775987_2776779_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213260	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters. NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	1.59563e-115
NZ_CP014335.1\|WP_062898885.1\|2759323_2761741_-\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0

>NZ_CP014335.1|WP_033845326.1|2770831_2772079_+|MFS-transporter
MKNKTFHFLWIGQSFANFGDVFYIVSVVSYLYHLTSKAMAAALVPFFVTLSLFISGIVAPIFFEKYKLKTLLSYGQMCKTFLLLFLSLFLHWGAEHYTAIVYVFVSLIAFLDGINNPIKNSLVPFIVSKEEILKANSFVNTLDQFIKLSAWPIGSLIVSVGSPFLLINITLLFYVVSSILMFLLHIQEHTKKKTAQGKGLKNFLLSISLGWEYTWRNVHAKSISFMSFFEGIGNGVWISAILYMYVKEQLHVGEEWWGYINSVFFGGMVIGGLLSVKFSQSVEKNQQFFVLFGPFCIAIVTLLFGTTTHGALALMYSTLYGIIEQWKVICLQTILQKNARMDALPHVFSVQGVISSVTFGISALLMSFIADVYGIRFSFYLSVCCFLISGWISYRQRKIWSYKENQKGEITGTIL
>NZ_CP014335.1|WP_062898886.1|2768599_2770186_+|phosphoenolpyruvate-carboxykinase-(ATP)
MGIANMTNKLDLLLQKPYVHHQLSVAELVEKVLQRNEGRLTHTGAVAVTTGKYTGRSPKDKYIVEEPSTKQTIDWGAVNQPMSPETFDKLYDKVLDYLMKKDELFVFKGFAGADPKSRLPIQVVNEFAWHNLFVHQLFIRPSAAELAAHEPQFTVICAPNFKADPKVDGTRSEAFIIISFERRTVLIGGTEYAGEMKKSIFSVMNYLLPEQGILPMHCSANVGQEGDVALFFGLSGTGKTTLSTDPNRRLIGDDEHGWSNRGIFNIEGGCYAKCINLSREKEPQIFDAIGFGAVLENVVLDDATRVPNYDDGTLTENTRAAYPLQAIKNIIDPSVAGHPSTIVFLTADAFGVLPPISKLTREQAMYHFLSGYTSKLAGTERGVTEPEATFSTCFGAPFLPRPAVEYAEMLGQKIAEHNVRVFLVNTGWTGGPYGVGSRMKLAYTRAMVQAAVEGELDNVETVQDPIFGLAIPTHVPGVPDDVLQPQNTWADKQAYEQKAKELAQKFRANFRKFAHIDPTIEKLGGPLV
>NZ_CP014335.1|WP_021322704.1|2766925_2768137_-|methionine-adenosyltransferase
MSAKRRLFTSESVTEGHPDKICDQISDAILDAILEKDPNARVACETSVTTGLVLVSGEITTSTYVDIPRIVRDTIREIGYTRAKYGFDADTCAVLTSIDEQSPDIAMGVDRALEAREGQMTDEEIEAIGAGDQGLMFGFACNETEELMPLPISLAHRLARRLAEVRKTDVLPYLRPDGKTQVTIEYDENGKPVRVDTIVVSAQHHPEITQEQIQRDIKEQVIKPVVPAELLDENTKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYVAKNIVAAGLADKCEVQLAYAIGVARPVSISIDTFGTGKVSEDILIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRTDIDLPWERTDKAALLKEQALALADK
>NZ_CP014335.1|WP_011232320.1|2766354_2766903_+|gamma-carbonic-anhydrase-family-protein
MIYPYKGKTPQIAASAFIADYVTITGDVVIGEETSIWFNTVIRGDVAPTVIGNRVNIQDNSILHQSPNNPLIIEDGVTVGHQVILHSAIVRKNALIGMGSIILDRAEIGEGAFIGAGSLVPPGKKIPPNTLALGRPAKVVRELTEDDIREMERIRREYVEKGQYYKALQQQRTSCADKKELP
>NZ_CP014335.1|WP_025039215.1|2764906_2765989_-|tetraprenyl-beta-curcumene-synthase-family-protein
MNIPKNPIALMKMVYRDVLPLVHRELAYWRRQAERIPDPELRRQALASIASKTFHCEGGSILALLAGENMEDCIRFIVAYQTISDYLDNLCDRSTSLDPLDFRALHDSMPDALTIGAEPSNYYRHRREQEDGGYLPALVRTCQEVLETVRHYETIAPFLHELAGYYCDLQVHKHVEASERVPRLEKWFAQYKDALPPMEWYEFSACSGSTLGIFCLVAYAFGESLPPEMARQVRDGYFPYIQGLHILLDYLIDQEEDRDGGDLNFCFYYPNETVMLERLCHFIEEADRHVGALPHGEFHRLIHRGLLGLYLSDAKVKKQRGLRRLARRLVRAGGAASQFFYWNGKAYRFWQERQKRLSFS
>NZ_CP014335.1|WP_011232318.1|2764271_2764859_+|methyltransferase-domain-containing-protein
MALMNILPFARFLLDQAVNEGDIAVDATVGNGHDTVYLAQRVGDFGHVFGFDIQSEAITAASARLAKHGLCGRATLFERSHSELLEALPADVHGRIAGAVFNLGYLPGGNKQIVTQPESTIEAVRQLLSVMKPGGVIVLVVYHGHPEGKRERDALLDYVRSLDQRRVHALKYEFINRQNNPPFLLALETRADKGA
>NZ_CP014335.1|WP_011232317.1|2763722_2763986_-|YtzC-family-protein
MATRQSVEEFLQRCEDVIRYAKEQYTEAQKQEHYNITEYTNAQQMLEQTVIDLAHLARSCNAQQREQLHRMRLQLEQLQNDMILLDR
>NZ_CP014335.1|WP_011232316.1|2763539_2763704_-|hypothetical-protein
MKRRLKQTNPEQKTRNGQNNNDLELGQDFDPVKLAKKQYEETGGQPIRSKQRNG
>NZ_CP014335.1|WP_011232315.1|2762129_2763329_-|MFS-transporter
MPRALWWLLVGMALNVTGASFLWPLNTIYLHEQLGQPLAVAGVVLMLNSGGSVIGSLAGGFLFDRIGGFRVLLAGAVLTMAALGGLSVWHGWPHYAVFLAFVGVGSGVVFPAASAYAGAIWPEGGRRAFNALYVAQNIGVAVGSALGGLVASYSFSLVFFANLLLYAAFLFTVVAGLRRVPLLPPPRKKRSGEAERAPSRSAGWALALLCAGYGLCWLSYVQWSTTIAAYTRELGIPVGQYSLLWTINGALIVLAQPLLSAVIRRFMPTLKRQIVIGFFIFAVSFAMLLGAHSFAEFAASMIVLTIAEMIVWPAIPAAVNEWAPPGKAGFYQGIVNGTATAGRMIGPVIGGSVADLFGMKLLIMMLALFALLAVLAALLHDRRLPKRTENADEKTAASV
>NZ_CP014335.1|WP_062898885.1|2759323_2761741_-|leucine--tRNA-ligase
MSFNHREIEQKWQDYWEKNKTFRTPDDDDKPKFYVLDMFPYPSGAGLHVGHPEGYTATDILARMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPAEFTQKNIENFRRQIKSLGFSYDWDREINTTDPNYYKWTQWIFLKLYEKGLAYMDEVPVNWCPALGTVLANEEVINGRSERGGHPVIRKPMRQWMLKITAYADRLLEDLEELDWPESIKEMQRNWIGRSEGAEIEFAVHGHDETFTVFTTRPDTLFGATYTVLAPEHPLVEKITTPEQKPAVDAYLKEIQSKSDLERTDLAKEKTGVFTGAYAIHPVTGDRLPIWIADYVLMSYGTGAIMAVPAHDERDYEFAKKFHLPMKEVVAGGDIEKEPYTGDGEHINSEFLNGLNKQEAIDKMIAWLEEHGKGRKKVSYRLRDWLFSRQRYWGEPIPIIHWEDGTMTPVPEEELPLVLPKTDEIRPSGTGESPLANIEEWVNVVDPKTGKKGRRETNTMPQWAGSCWYYLRYIDPHNDKQLADPEKLKKWLPVDVYIGGAEHAVLHLLYARFWHKFLYDLGIVPTKEPFQKLFNQGMILGENNEKMSKSKGNVVNPDDIIESHGADTLRLYEMFMGPLEASIAWSTKGLDGARRFLDRVWRLFVTENGELNPNIVDEPANDTLERIYHQTVKKVTEDYESLRFNTAISQLMVFINEAYKAEQMKKEYMEGFVKLLSPVCPHIGEELWQKLGHTDTIAYEPWPTYDETKLVEDVVEIVVQINGKVRSRLHVPVDLPKEALEERALADEKIKEQLEGKTVRKVIAVPGKLVNIVAN
>NZ_CP014335.1|WP_062898887.1|2772437_2773340_-|transposase
MAKQRIDHDRLFKELLSTFFEDFLLLFFPDVYEHIDVHHLSFLSEELFTDVTAGEKHRVDLLVETKVKGEDGLVIVHVEHQSYKQRTFPERMFLYFSRLFQKHRRRILPIAIFSYDERHDEPSSLMIQFPFLMVLDFRFLTVELHKLPWREYIRRDNPVAAALLSKMGYNESEKVEVKKEFLRMLVRLELDEAKQRLLFGFFETYLRLSEAEEIQLRNEVSQMETKEAKQVMELIVSYEQRGMEKGIQQGVKQGMKQGRQKGIEEGKLDVVKRMLAKGYDVDTIHELTGLPVEKIERVKG
>NZ_CP014335.1|WP_033009830.1|2773573_2773816_-|DUF2584-domain-containing-protein
MGMPMEVQTVIVTKGKEQRVQGNVFVLEKDGYRLYPLDVPLEVRRTVQSEASGIAVVKKLEWEDNRTTVTYELVSLYSTN
>NZ_CP014335.1|WP_062898888.1|2773884_2774673_-|S9-family-peptidase
MDGDIIDQYRFPSPHPGIDVFFVTYMSQGLKVKGFLAAPKRKGVYDGFLYLRGGIKNVGQVRVPRLVQFASHGFVVFAPLYRGNGGGEGNEDFAGEDRYDALAGFHLLRRHPLVHPGRVHMFGFSRGGAMALHAALMAEGVCSVAVWGGVADMELTYWERPDLRRMMKRVIGGTPNKCPERYRHRTPLYHLERLKAPVLIIHGERDENVSIEHAWRLERRLKQLGKPVTAWYFPEFTHYFPPPANRKTVQRLTQWMKQQPTV
>NZ_CP014335.1|WP_062898889.1|2774964_2775972_+|ABC-transporter-substrate-binding-protein
MKKWAVWLCSLLLLLPLSACTNDGGQSEKPLQKVRLAEVTHSIFYAPQYVALAKGFFKEEGLDVELTTTWGGDKTMTTLLSGGADIALVGSETSIYVYSQGTDDPVINFAQLTQTDGTFLVSRKKIGHFTWEMLKGSTFLGQRKGGMPQMVGEFVLKKHGIDPHNDLHLIQNVDFANIANAFASGTGDFVQLFEPTASIFEQEGKGYIVASFGTESGRVPYTSYMAKRSYMNENKDVIEKFTRAIYKAQQWVESHSAAEIAKAIQPYFKDTDSAIIEKVVERYKSQGTYATDPILDEEEWNNLQTIMAEAGELPKRIDLNTLVDSSFAKNAMNTQ
>NZ_CP014335.1|WP_062898890.1|2775987_2776779_+|ABC-transporter-ATP-binding-protein
MFLSIDRLSHTYLTKTNAVTALVDVSLSVEKGEFVSFLGPSGCGKTTLLSIIAGLIEPTEGTVLMEGRPLWPSGTAAPAARRAVGYMLQQDYLFPWKTIEENILLGLKITDTLTADTKERALALLAEIGLGGVELYYPSQLSGGMRQRAALVRTLATDPKLLLLDEPFSALDQQTKLKLEELVWATLRQYEKTAVLVTHDIEEAIAMSDRIFLFSPRPGRLVRTFVIPDELRCRPPLAARQQPSFPALFQSIWKEMEALESAQ
>NZ_CP014335.1|WP_011232329.1|2776762_2777572_+|ABC-transporter-permease
MNPPNERIEALHTEYLTVLRKEQRIIRLWQTVLLVAFFAVWEAASRFHWVDPLLFSSPSAIAKLFVEKMSDHSLFAHTWATLFETLLGFFIGTAGGALIGALLWWFPRLAKTLDPYLVVFNAMPKVALGPILIVALGPGFTSIVAMGVVISIIITTIVVYSAFQEVDPNYLKVLRTFGATRYQCFQEAVLPASFPAIISTLKVNVGLAWVGVITGEFLVSKQGLGYLIIYGFQVFNFTLVLMSLLIVALLSTVMYQLVALIEKKWGNRR
>NZ_CP014335.1|WP_011232330.1|2777690_2778158_-|nucleoside-triphosphatase-YtkD
MHEFRDYYGHRVRLAFADHPFSPSPGHVWVICRYGGRWLLTDHPRRGLEFPGGKVEEGETAAEAAAREVMEETGGIVGRLEYIGQYEVEPDIVKNMYFADIAALVERGSYLETNGPVLLEALPDDIRADQRFSYFMKDDVLSLALAKLKQRGLID
>NZ_CP014335.1|WP_011232331.1|2778216_2778549_-|hypothetical-protein
MADERKKTYYVSMATGEISQLKTASPWDFQIEATDEEITQLREYFDQNYSTDWQAFWRTHVPYIQYHYDRENDAYDRTLTKIYEMIYRLGNEEAKEHIRSLGILPDEKEE
>NZ_CP014335.1|WP_013524459.1|2778610_2779006_-|phage-holin-family-protein
MNKPIPMVAVSLFGSFLSLFVGSVDSFVVILLALVIVDYLTGIAASAVEGKLSSQVGFRGIIRKLLIFVLVAASHLVDLAIGWNMHVIRDAIIFFYIANEFISIVENAGRAGVPIPSVLRKAIELLKDEIK
>NZ_CP014335.1|WP_014196600.1|2779159_2779600_-|DNA-starvation/stationary-phase-protection-protein
MATRLIDLVNKQIANWTVLYVKLHNYHWYVTGPQFFTLHEKFEELYNEAATHIDALAERLLALGGKPVATMKDCLEQASVKEAAGTETAEQMVASIVRDFETMIGELKEGMQLADEVNDETTGDMLLGIHRSLEKHVWMLKSFLGR

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP014335_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP014335_7

2814879-2814961

Orphan

Consensus_repeat	Method
ATGGCCACCAAAGACGAACTCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP014335_7

>merge|NZ_CP014335|7|2814879-2814961|CRISPRCasFinder
ATGGCCACCAAAGACGAACTCGCCGAGCTCCGATCCAAAGTGGACGACATCGAAGCGAAAATGGCCACGAAAGACGAACTCGC

>NZ_CP014335|7|6|2814879-2814961|CRISPRCasFinder
ATGGCCACCAAAGACGAACTCGC	CGAGCTCCGATCCAAAGTGGACGACATCGAAGCGAAA
ATGGCCACGAAAGACGAACTCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014335.1\|WP_014196625.1\|2815396_2815858_-\|YobA-family-protein	unknown	unknown	gnl\|CDD\|371575
NZ_CP014335.1\|WP_011232354.1\|2807631_2808258_+\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NZ_CP014335.1\|WP_025038907.1\|2808461_2808749_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_033013366.1\|2829972_2830461_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_CP014335.1\|WP_021321915.1\|2830572_2831748_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NZ_CP014335.1\|WP_011232372.1\|2812080_2813079_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_CP014335.1\|WP_011232390.1\|2829663_2829915_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_025038910.1\|2803280_2804450_-\|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|179997
NZ_CP014335.1\|WP_021322727.1\|2813109_2814051_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP014335.1\|WP_021321918.1\|2824941_2825850_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP014335.1\|WP_062898896.1\|2804331_2806374_-\|1,4-alpha-glucan-branching-enzyme	unknown	unknown	gnl\|CDD\|235445
NZ_CP014335.1\|WP_014196629.1\|2823895_2824108_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP014335.1\|WP_011232385.1\|2824152_2824971_+\|protein-glutamine-gamma-glutamyltransferase	unknown	unknown	gnl\|CDD\|235109
NZ_CP014335.1\|WP_162837030.1\|2828578_2829451_+\|nuclease	unknown	unknown	gnl\|CDD\|214615
NZ_CP014335.1\|WP_011232387.1\|2825976_2826654_+\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NZ_CP014335.1\|WP_014196631.1\|2827030_2828332_-\|DnaD-domain-protein	unknown	unknown	gnl\|CDD\|226445
NZ_CP014335.1\|WP_062898897.1\|2806550_2807501_+\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
NZ_CP014335.1\|WP_062898898.1\|2811107_2812088_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_CP014335.1\|WP_011232356.1\|2808758_2809313_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP014335.1\|WP_041468039.1\|2809552_2811055_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375438

Protein	Function_ID	Function_description	E-value
NZ_CP014335.1\|WP_014196625.1\|2815396_2815858_-\|YobA-family-protein	gnl\|CDD\|371575	pfam11518, DUF3221, Protein of unknown function (DUF3221). This family of proteins with unknown function appears to be restricted to Bacillus. Some members in this family of proteins are annotated as YobA however this cannot be confirmed. YobA is a protein with unknown function.	5.75925e-22
NZ_CP014335.1\|WP_011232354.1\|2807631_2808258_+\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	5.85786e-43
NZ_CP014335.1\|WP_162837030.1\|2828578_2829451_+\|nuclease	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	1.39945e-17
NZ_CP014335.1\|WP_033013366.1\|2829972_2830461_-\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	1.49714e-59
NZ_CP014335.1\|WP_021321915.1\|2830572_2831748_+\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.38345e-80
NZ_CP014335.1\|WP_011232372.1\|2812080_2813079_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	2.83642e-90
NZ_CP014335.1\|WP_025038910.1\|2803280_2804450_-\|glucose-1-phosphate-adenylyltransferase	gnl\|CDD\|179997	PRK05293, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
NZ_CP014335.1\|WP_021322727.1\|2813109_2814051_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	5.33596e-63
NZ_CP014335.1\|WP_021321918.1\|2824941_2825850_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	3.68003e-17
NZ_CP014335.1\|WP_062898896.1\|2804331_2806374_-\|1,4-alpha-glucan-branching-enzyme	gnl\|CDD\|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0
NZ_CP014335.1\|WP_011232385.1\|2824152_2824971_+\|protein-glutamine-gamma-glutamyltransferase	gnl\|CDD\|235109	PRK03187, tgl, transglutaminase; Provisional.	2.07778e-159
NZ_CP014335.1\|WP_011232387.1\|2825976_2826654_+\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	6.68956e-56
NZ_CP014335.1\|WP_014196631.1\|2827030_2828332_-\|DnaD-domain-protein	gnl\|CDD\|226445	COG3935, DnaD, Putative primosome component and related proteins [DNA replication, recombination, and repair].	1.59345e-16
NZ_CP014335.1\|WP_062898897.1\|2806550_2807501_+\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	3.0539e-99
NZ_CP014335.1\|WP_062898898.1\|2811107_2812088_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	4.20731e-94
NZ_CP014335.1\|WP_011232356.1\|2808758_2809313_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	3.3296e-19
NZ_CP014335.1\|WP_041468039.1\|2809552_2811055_-\|hypothetical-protein	gnl\|CDD\|375438	pfam17936, Big_6, Bacterial Ig domain. This domain is found in a wide variety of extracellular bacterial proteins often in multiple tandem copies.	6.7466e-09

>NZ_CP014335.1|WP_021322727.1|2813109_2814051_-|iron-siderophore-ABC-transporter-substrate-binding-protein
MLQKKWTSLLAMLMALFVLLVPLAQPAAPVEAASKTRVFKTELGKLVIKGTPKRIVTLSMAGTDAVVTLGLKPVGYTISNSGTVPTYLRNKLKGVPSVGALSAPSLERIAALKPDLIIIDHEFEFHKAIIPQLKKIAPVAGFRANSYKEAMNQLLVLGDILGRKAKAKSFVNQFYKELKSQQAKLKDKNLRVLGFFVNKDGINVWQDNSFSGSIFTALKADYAFKEKGDEYSDFKTVSLERILEIDPDVLFAYTDPGKNDLKKVKANPIWSQLKAVKEKRVVEVNRDLWSRSRGPLAAKLIVKEAASILKRYQ
>NZ_CP014335.1|WP_011232372.1|2812080_2813079_-|iron-ABC-transporter-permease
MAYGKRAIWISSMLVLGIILLIIVSLVSGPFFVPIPKVLDVLLHDDGSKARTVVWNLRFPRALLAVLIGASLAVAGAMMQCLTKNPMAEPKIMGVSAGAAAMVVLIEYFFAGLPLLFFSPLVFLGAAVGGATVYSLSLKRGSLSPVRLTLAGVAVSAFLHAITVGILVLLGQDAAAVYAWLAGGLNGLTWRHVSLIAPWSLAGLLLSIMIASKMDLLELGDDTAKGLGVHVGILKTVMAVIIIILAGSAVSVSGVIGFIGLIIPHIVRKMVGVNYTYIVPVSALCGGMLLLTADLLARLVAQPIELPVGVFTAAIGCPYFLYLIRKQGEWNA
>NZ_CP014335.1|WP_062898898.1|2811107_2812088_-|iron-ABC-transporter-permease
MRKRDVGLVAGLALLLVIIVPLSACFGDVKIPVSQVWEAFFNRKSSLNGEIVWEYRLPRILVGLFVGANLAVSGALLQAVTQNPLAAPNVIGMTAGASLFAVLALLIIPHFPVSGLPFVTFFGALFAGLCVYAFAWKKGMDKGRFALSGIAFDALFQAVITGILVFATKGIDAAVIWLAGSLWGRTWEHVFLIVPWSVIGLGFAYLCYRRMNVLQLHDDIAASLGLRVQAARFLIFLIAVGLCGSAVAVSGPIGFVGLVIPHLARLLTRADYQRLIPVSALLGAILMISADTAGRTIAAPIEIPVGILTAFIGAPYFLFLLRRAKL
>NZ_CP014335.1|WP_041468039.1|2809552_2811055_-|hypothetical-protein
MISSFVTASLVIAGAAESEAYAAKPAKLAIESAQPVNASTVKEYIVKGKGLKGAKIKIVITDGKASVTHYTVVQKSGSFEAPVNVSTLRDGTLTVSVTQIIKGQKHSRVQKKIIKDTKAPSVPVITNKGWINAKQQNAYAVQGTAEPHSAVKVSLSDGKQRITKTVHADGKGRFRAVIDARKLAEGEITVSAVSVDSAGNQSGQSKKVLRKDVSIEAPELLNEGYINAFNYEAYPVTGTGTPGEKVVVEAADGKKSVSASGLVDEDGNYEVEINTSSLKDGKITIRVKTIDQAGNESRMASVVLIKSLTSPAKPSIENKGYVNASADATAYEVTGKGEPGAEVEVTLSDGTNEISTVGTVEENGRYRVEADISPLSDGLITITAVQTSATGNVSPEATTTVWKDTAVAAPSLNALPAVTNQNQAAYTIAGTAESNASVQIIITDGQKSLVERTSADSNGNFSKTIDLSAFNNGQLMIIVTQEDKAQNHSEATTATVTKGQ
>NZ_CP014335.1|WP_011232356.1|2808758_2809313_-|GNAT-family-N-acetyltransferase
MGNIQPRRLVTASGQPIVIRTAWPEDAERVVAFVKAVAAEAPYLLTTEAEVVTTSERQKQWLQQIMDDPGKLAIVAEQEGDIIGFLDFHNGNKQRTKHQGSFGMSVKKDFRDQGIGTALLAALLDWAKENPLIEKVCLEVVADNTNAIRLYQKFGFVEEGVKKKAAKIDDGTYWDLILMARFVK
>NZ_CP014335.1|WP_025038907.1|2808461_2808749_-|hypothetical-protein
MSAGRSLDEHFLPFYCAGLRFGAAAGVTRRENVSDKGMRLLPLGVRLMKPQREQYKRMAACERKAAMLVLVEMPNLLSFGPDVLLFLPLLLLEDL
>NZ_CP014335.1|WP_011232354.1|2807631_2808258_+|LysE-family-translocator
MGIGTIFSFFGVAVLLTLAPGPDILFVIAQSLSQGKQAGIATALGLCTGLLVHISAATLGVSAVIYQSALAFAIVKYAGAAYLLYLAWQAFREKDSSLAFGRQKPMAYASLYKKGIVMNVLNPKVSLFFLALLPQFVDPSEGRVPQQMLLLGAVFLAQALAVFTLVSIGAEKLRHLLLSNKRIAKRINRLKGALFALIGIQIAFSERS
>NZ_CP014335.1|WP_062898897.1|2806550_2807501_+|cation-transporter
MAPTLYDFHHLPHVKTQNESKKALWVTLLLTMFFTAVEIIGGLISNSLALLSDSAHMASDVLALGLSMVALYMATRPPNRRFTFGFLRFEIITSFLNGLTLAVIALWILWEGIQRFLHPEPINFRLMLGIAAISLVVNLTLTIVLSRSTKEEDNLNVQSALWHFIGDLISSIGVIVSALLIYFTGWTVFDPIISLVIAAIIFTGGAKIMRESYLILMEAVPDGFDLEQIRADIRKIEGVEDVHDMHLWAISTDHYSLSAHVFVNERIQPLCVILAVNEMLKEKYGIEHATIQVEHAMLHDHGRYGRAFLEKKAFHE
>NZ_CP014335.1|WP_062898896.1|2804331_2806374_-|1,4-alpha-glucan-branching-enzyme
MYGHHFASERMRSSLIAANPTDLEVYLFHEGRLYQSYELFGAHVIRGGGAVGTRFCVWAPHAREVRLVGSFNDWNGANSSLTKVNDEGVWTIVVPENLEGHLYKYEIITPDGRVLLKADPYAFYSELRPHTASIVYDLKGYEWNDSPWQRKKRRKRIYDQPMVIYELHFGSWKKKPDGRFYTYREMADELIPYVLERGFTHIELLPLVEHPLDRSWGYQGTGYYSVTSRYGTPHDFMYFVDRCHQAGLGVIIDWVPGHFCKDAHGLYMFDGAPTYEYANEKDRENYVWGTANFDLGKPEVRSFLISNALFWLEYYHVDGFRVDAVANMLYWPNNDRLYENPYAVEFLRQLNEAVFAYDPNVLMIAEDSTDWPRVTAPTYDGGLGFNYKWNMGWMNDMLKYMETPPHERKYAHNQVSFSLLYAYSENFILPFSHDEVVHGKKSLLNKMPGSYEEKFAQLRLLYGYMMAHPGKKLLFMGNEFAQFDEWKFEGELDWMLFDFELHRKMDEYVKQLIACYKRYKPFYELDHDPRGFEWIDVHNAEQSIFSFIRRGKKEGDVLVIVCNFTNQAYDDYKVGVPLLAPYREVLNSDAAEFGGSGHVNGKRLPAFSEPFHGKPYHVRMTIPPFGISILRPVQKRGERKQNEEEVHRHVIGRRARKPASLADEKHRETSRAVWGEVPDH
>NZ_CP014335.1|WP_025038910.1|2803280_2804450_-|glucose-1-phosphate-adenylyltransferase
MKKKCIAMLLAGGQGSRLRSLTKNIAKPAVPFGGKYRIIDFTLSNCTNSGIDTVGVLTQYQPLLLHSYIGIGSAWDLDRRNGGVTVLPPYSASSGVKWYEGTANAIYQNMNYIEQYDPDYVLVLSGDHIYKMDYQQMLDYHIAKQADATISVIEVPWEEASRFGIMNTNENMEIVEFAEKPANPKSNLASMGIYIFNWPLLREYLQIDNADPHSSHDFGKDVIPRLLRENKRLVAYPFKGYWKDVGTVKSLWEANMDLLDEHNELDLFDRSWRIYSVNPNQPPQYIAPEAEVSDSLINEGCVVEGTVERSVLFQGVCIGKGAVVKESVIMPGATVGEGAYVERAIVTPEIVIPPHSTVSPGDADDDVVLVTTEWIKQRNKDTARKDGAQ
>NZ_CP014335.1|WP_014196625.1|2815396_2815858_-|YobA-family-protein
MAGCSGQTDRYAIEGYVVRKEGGSILVVSSDPQDFRSTGGLKEFYNAILVSSAPARVNIGQKVQVWIDGGIAESYPGQGKAGKVLVVPSSPRDGASLSEEEAIRQALKQEESRLEHMIPVIRAVHYDKQADTWMIQIKDAHERTEFDVRIKDE
>NZ_CP014335.1|WP_014196629.1|2823895_2824108_-|hypothetical-protein
MQNGKVLHVLDEKSRLPISTARGKPPSSSLHLGVAEDGTTTCFTDPGVGLEAALFGRLTVHPVALQKPSM
>NZ_CP014335.1|WP_011232385.1|2824152_2824971_+|protein-glutamine-gamma-glutamyltransferase
MIRVLSPINFDVSSSFSLPASEQRILDALVSSPKLYTYANKHQLRFEIALRDRIVRAAGELAKSRARFAIFRFSRCNSDFWTRDERGGFRLRPDVTASEAIQDIFVHSERYAFECATAIVIVFYKAVLDVIDPAAFNRLFADLLLYDWHTDRDLGIQTKKDEHFLPGDCLYFKNPEFDPLTPQWQGENAIYLGDGFFYGHGIGIQTKEGIIAALNRKRKRGATKSAYLLPDITQVDFAYLSQFARGFDEFRLPIRRSSFIFGTLGSAAFLHR
>NZ_CP014335.1|WP_021321918.1|2824941_2825850_-|DMT-family-transporter
MKPPSTAKAYAALFIGALAVSTSAIFVKWSQAPSAVIAFYRLFLAVAIMTPLFLRHRSELRGVSRRDWLFSLCSGVLLAFHFILWFESLDYTSVASSVVLVTLQPLFAFAGGALFFRERLTVGAVGSAVLAIIGSILISWGDFRVSGEALYGDGLALLACAFVTAYWLFGQEVRQRLSLMTYTYIVYSISAAVLWLYAMLFRLSLTAYQLTDWLCFLALAVIPTLLGHSVMNWAVKWVSASTVSMAILFEPIGASALAYWLFGEPIRPFQWIGGIFILTGIALYLWEKNEKGPLTVQERSGP
>NZ_CP014335.1|WP_011232387.1|2825976_2826654_+|MgtC/SapB-family-protein
MMFDPFLKLGISAILGLIIGLERELKRKPVGLKTCLVISISSCLLTIVSIESAYVFPLKDHITMDPLRLAAQIVSGVGFLGAGVILRRGNDSITGLTTAAIIWGAAGIGVAVGAGFYWESAFGVALLIVSVELIPFLINFFGPKQLREKEVLLQITVADAKNITKVIDHLKQQDINIKTMRIKDVEENEHLLKLRAVIDQKRSTAELYYVIRSIDDVVHVDIESG
>NZ_CP014335.1|WP_014196631.1|2827030_2828332_-|DnaD-domain-protein
MSNLLFDDQPLVILPQLALAIGLNESIVVQQLHYWLKKSENVHDGYKWVYNTYADWQRQFPFWSESTIRRIILKLEKMGIIVAANFNRSKIDKTKWYRIDYDKLAEITKEISEMSDGQHGQAADDGVMTAHNGVSIVQGAVSFTQNGVSFVHDEGLTTHDGDSIVQDGISAVQGGASVVQGGMLTAQDGILTVQNRVLPTEDGGSMRQSSVSTIQQDQISAVYDGVSIGQNEQTMGETVRPFAQNEPSSWSNWAVEVLNLTRPIPETTTEMTSEIKREDEEDARVRTYKEIVRFCEENGFGVIGDYLREKINAWVDDASEELVLEALKIAVENGAKRWVYVETILRDWTEKGYRTVDEVRAARLAFRKERMKQRSAPPSSDGGRTMRKPIRTEIVPDWLKMDYSQPEDDDFDIEQARRELEERLKKYKTNPDG
>NZ_CP014335.1|WP_162837030.1|2828578_2829451_+|nuclease
MVIFLFCFLLMFPISAFAHPGELDELGGHFRGSDCVYLLHEPTALAKQAKTKQELVQLIQTYNGNERCKRHLTPERIDLDGHTLGKKEDRSTLRLGRTYPAELVECIDGDTAKFRVNGHVYTTRFLFIDTPESTIQVEPYGKEASRFTCSRLHQGNILLETDGDALFDKYQRLLAWVWVGKRLLQEDLAKAGLVEDFYDYGDYKYEARVRKAYEEAKRTGAGMYGKHAAGEREGAGTETRPQTGEKTAKTVHPPALENKTPLERSGRPVLYTLLGLAAAAALYWLIRRLT
>NZ_CP014335.1|WP_011232390.1|2829663_2829915_-|hypothetical-protein
MNVMPIRLFTIQDGEGFVADAFQCPVTGNLIYKSSGTPSVVAYADLTDEQIMRLEKYGFRRLGESPARMESGPDGIEELLPRQ
>NZ_CP014335.1|WP_033013366.1|2829972_2830461_-|N-acetyltransferase
MIRDAAAADLPHIVRIYNETIPSRMVTADLEPVSVESRRAWFEAHDPHNRPLWVVEDDGAVCAWLSFQSFYGRPAYRHTAEVSIYIAETHRGRGLGTKLLERAVERAPELGIKTLLGFIFAHNEPSLRLFSRFGFERWGYFPRVAELDGVERDLVIVGKRLV
>NZ_CP014335.1|WP_021321915.1|2830572_2831748_+|MFS-transporter
MKRQLVVYLVSLAAFLGPFTQTIYTPILPEVREAFATSSFLINLTISIFTFFLAMMQIVYGPLTDRKGRRTVLLGGIVIYIAASLGCFFSTSIYALLFFRALQAVGIAAGSVVAATVIGDLFTGKERGRAMGTFQMMVSLGPVVGPIVGGFLAEHFPFRTVFLALVAVGGLVGAGNFLLLKETKPETAVSSPFRLSDFASVLRRRAGSSIVLLGFVQYYSLYNFLVFLPSILTDRYGLSAQEKGTVYLAMSSMIVIGSFLGGRLQGRFPERRILLAASYLTVLSIFFFLIAAQRSLSLLVLAIALFGLFLGLSLPVQTTVLTNVFQANRSTAIGVYNFFRYMGMAFGPMIGSALFAAGGYHLVYGIDDILFFACALLLTVRVARTRRQSAV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP014335_3	3.1\|965105\|34\|NZ_CP014335\|CRISPRCasFinder	965105-965138	34	NZ_AP022559	Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence	29918-29951	1	0.971

1. spacer 3.1|965105|34|NZ_CP014335|CRISPRCasFinder matches to NZ_AP022559 (Geobacillus subterraneus strain E55-1 plasmid pGspE55-2, complete sequence) position: , mismatch: 1, identity: 0.971

attgcggaaatgagagtgaaaacaaggaaaattc	CRISPR spacer
attgcggaaatgagagcgaaaacaaggaaaattc	Protospacer
****************.*****************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

230015 : 304013

uncultured_virus(10.53%)

protease,holin,tRNA,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023634042.1\|230015_230750_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_013144057.1\|231105_231390_+	co-chaperone GroES	A0A221S3C8	uncultured_virus	1.1e-18	50.5
WP_011229758.1\|231494_233111_+	chaperonin GroEL	A0A219YK78	uncultured_virus	1.3e-164	59.0
WP_062898320.1\|233779_235024_-	cation:proton antiporter	NA	NA	NA	NA
WP_062898321.1\|235033_235528_-	cation:proton antiporter regulatory subunit	NA	NA	NA	NA
WP_062898322.1\|235895_237266_+	class II fumarate hydratase	NA	NA	NA	NA
WP_015373801.1\|237400_238624_-	Nramp family divalent metal transporter	NA	NA	NA	NA
WP_062898323.1\|238752_239709_+	MoxR family ATPase	NA	NA	NA	NA
WP_044742400.1\|239714_240890_+	DUF58 domain-containing protein	NA	NA	NA	NA
WP_062898324.1\|240886_243049_+	DUF4129 domain-containing protein	NA	NA	NA	NA
WP_062898325.1\|243253_244786_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	7.0e-19	30.1
WP_062898326.1\|245066_246392_+	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	9.9e-54	32.6
WP_062898327.1\|246530_247073_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_011229765.1\|253430_253880_-	Hsp20/alpha crystallin family protein	NA	NA	NA	NA
WP_011229766.1\|254240_254729_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	3.1e-21	42.9
WP_011229767.1\|254721_255870_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_011229768.1\|255866_257162_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	3.8e-18	33.6
WP_014194762.1\|257222_257966_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3HI61	Synechococcus_phage	9.4e-46	42.5
WP_014194763.1\|257953_258208_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_014194764.1\|258204_258891_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_021321603.1\|258874_261103_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.9e-168	42.1
WP_011229773.1\|261078_262491_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.3e-51	34.7
WP_062898329.1\|262614_263655_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FC27	Synechococcus_phage	4.7e-67	43.6
WP_011229775.1\|263651_264284_+	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	4.1e-26	37.4
WP_062898330.1\|264246_265785_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	7.9e-79	53.0
WP_011229777.1\|265808_267101_+	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
WP_011229778.1\|267249_267414_-	hypothetical protein	NA	NA	NA	NA
WP_011229779.1\|267410_267656_-	DUF2892 domain-containing protein	NA	NA	NA	NA
WP_023633363.1\|267752_269498_+	adenine deaminase	NA	NA	NA	NA
WP_082816464.1\|269516_270548_+	DUF3048 domain-containing protein	NA	NA	NA	NA
WP_011229782.1\|270640_270976_+	hypothetical protein	NA	NA	NA	NA
WP_062898332.1\|271073_271793_+	heptaprenylglyceryl phosphate synthase	NA	NA	NA	NA
WP_011229784.1\|271821_273996_+	DNA helicase PcrA	A7KV33	Bacillus_phage	2.2e-135	42.1
WP_014194775.1\|274016_276029_+	NAD-dependent DNA ligase LigA	A0A0K2QQN8	Ralstonia_phage	1.2e-127	40.0
WP_023633361.1\|276025_277249_+	CamS family sex pheromone protein	NA	NA	NA	NA
WP_023633360.1\|277424_277988_+	TIGR00730 family Rossman fold protein	A0A1V0S9E9	Catovirus	1.0e-12	29.1
WP_020279425.1\|278010_279453_-	flavin monoamine oxidase family protein	A0A2K9L3H9	Tupanvirus	1.6e-12	25.2
WP_020279426.1\|279587_280361_-	VOC family protein	NA	NA	NA	NA
WP_011229789.1\|280390_280897_-	hypothetical protein	NA	NA	NA	NA
WP_011229790.1\|281055_281346_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_011229791.1\|281358_282816_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_031212135.1\|282829_284260_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_023633356.1\|284435_285740_+	homocysteine synthase	A0A0B5JD48	Pandoravirus	4.1e-20	26.4
WP_011229818.1\|285964_286594_-	ABC transporter permease	NA	NA	NA	NA
WP_011229819.1\|286848_287976_-\|holin	betaine/proline/choline family ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.5e-29	35.5
WP_031206583.1\|287992_288895_-	glycine/betaine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014194801.1\|289369_290017_-	hypothetical protein	NA	NA	NA	NA
WP_062898333.1\|290161_291652_+	TIGR02677 family protein	NA	NA	NA	NA
WP_062898334.1\|291654_292851_+	TIGR02678 family protein	NA	NA	NA	NA
WP_062898335.1\|292810_296932_+	TIGR02680 family protein	NA	NA	NA	NA
WP_062898336.1\|296928_298149_+	TIGR02679 family protein	NA	NA	NA	NA
WP_082816465.1\|298216_298582_+\|transposase	transposase	NA	NA	NA	NA
WP_062898337.1\|299276_300935_-\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_062898338.1\|301258_302059_-	AAA family ATPase	NA	NA	NA	NA
WP_015374208.1\|302051_303299_-\|transposase	IS481 family transposase	M4T586	Rhodobacter_phage	1.3e-10	25.1
WP_011229674.1\|303449_304013_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_2

307034 : 359805

Bacillus_phage(16.67%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062898340.1\|307034_308168_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_082816466.1\|311420_311816_+\|transposase	transposase	NA	NA	NA	NA
WP_011229827.1\|312731_312956_-	hypothetical protein	NA	NA	NA	NA
WP_062898341.1\|313092_314148_+	P1 family peptidase	NA	NA	NA	NA
WP_011229829.1\|314230_315463_-	MFS transporter	NA	NA	NA	NA
WP_023633344.1\|315662_316316_-	PspA/IM30 family protein	NA	NA	NA	NA
WP_023633343.1\|316275_316800_-	hypothetical protein	NA	NA	NA	NA
WP_011229832.1\|316999_317323_+	hypothetical protein	NA	NA	NA	NA
WP_062898342.1\|317707_320017_-	YhgE/Pip domain-containing protein	NA	NA	NA	NA
WP_023633341.1\|320670_322044_-	GHKL domain-containing protein	Q8QKV7	Ectocarpus_siliculosus_virus	5.7e-12	26.0
WP_062898343.1\|322024_322696_-	response regulator transcription factor	W8CYM9	Bacillus_phage	2.8e-33	36.2
WP_062898344.1\|322869_324075_+	PDZ domain-containing protein	W5SAB9	Pithovirus	1.4e-14	29.8
WP_031212124.1\|324146_324488_+\|transposase	transposase	NA	NA	NA	NA
WP_062898345.1\|324591_325839_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1L2BWW3	Bacteriophage	6.4e-63	37.5
WP_011229842.1\|327712_328102_+	DUF962 domain-containing protein	NA	NA	NA	NA
WP_062898347.1\|328238_329105_-\|transposase	transposase	NA	NA	NA	NA
WP_033024619.1\|329319_329859_+	membrane protein	NA	NA	NA	NA
WP_011229845.1\|329881_331399_+	flotillin family protein	A0A2I2L4B2	Orpheovirus	2.7e-07	27.1
WP_011229846.1\|331541_332462_+	diacylglycerol kinase	A0A1V0SBJ0	Catovirus	1.2e-26	30.9
WP_062898348.1\|332539_333913_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	2.6e-126	49.6
WP_023633335.1\|334463_334631_+	hypothetical protein	NA	NA	NA	NA
WP_062898349.1\|335116_336250_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_015373875.1\|336746_336911_+	hypothetical protein	NA	NA	NA	NA
WP_062898351.1\|337292_338762_+	alanine:cation symporter family protein	NA	NA	NA	NA
WP_023633795.1\|339173_339521_-	hypothetical protein	NA	NA	NA	NA
WP_062898352.1\|339610_339982_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013522911.1\|339944_340370_-	SRPBCC domain-containing protein	NA	NA	NA	NA
WP_023633793.1\|340624_342013_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	D0R096	Streptococcus_phage	3.7e-51	31.5
WP_062898353.1\|342185_342947_-	sporulation protein	NA	NA	NA	NA
WP_011229863.1\|343179_344361_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_011229864.1\|344652_345696_+	NDP-sugar synthase	I7I009	Enterobacteria_phage	8.4e-16	29.4
WP_011229865.1\|345692_346880_+	glycosyltransferase	NA	NA	NA	NA
WP_011229866.1\|346860_347976_+	hypothetical protein	NA	NA	NA	NA
WP_033007774.1\|347926_349336_+	phosphomannomutase/phosphoglucomutase	A0A127AWJ1	Bacillus_phage	1.8e-50	29.7
WP_062898354.1\|349551_351204_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_031212548.1\|351450_351855_+	ATP-binding protein	NA	NA	NA	NA
WP_011229870.1\|351872_352205_+	STAS domain-containing protein	NA	NA	NA	NA
WP_062898355.1\|352211_353738_+	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_011229872.1\|354023_354437_+	RDD family protein	NA	NA	NA	NA
WP_062898356.1\|355094_356348_+	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	3.6e-13	50.0
WP_011229874.1\|356768_358457_+	phosphomethylpyrimidine synthase ThiC	NA	NA	NA	NA
WP_011229875.1\|358686_359805_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A0P0IJS6	Lactobacillus_phage	1.5e-87	45.4

DBSCAN-SWA_3

465191 : 542345

Bacillus_phage(38.46%)

tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011229816.1\|465191_466382_+\|transposase	ISL3 family transposase	A0A0A8WEF4	Clostridium_phage	2.2e-28	25.2
WP_013522997.1\|466966_467371_+	two pore domain potassium channel family protein	NA	NA	NA	NA
WP_025949132.1\|467437_467914_+	thioredoxin-dependent thiol peroxidase	NA	NA	NA	NA
WP_020279379.1\|468138_468597_+	peroxide-responsive transcriptional repressor PerR	NA	NA	NA	NA
WP_011229983.1\|468621_468975_-	YgzB family protein	NA	NA	NA	NA
WP_025039077.1\|469350_470214_+	hypothetical protein	NA	NA	NA	NA
WP_011229985.1\|479231_479897_-	hypothetical protein	NA	NA	NA	NA
WP_062898384.1\|479949_481092_+\|tRNA	tRNA epoxyqueuosine(34) reductase QueG	NA	NA	NA	NA
WP_011229987.1\|481153_482017_+	amidase domain-containing protein	NA	NA	NA	NA
WP_011229988.1\|482037_482511_+\|tRNA	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	NA	NA	NA	NA
WP_011229990.1\|482836_484732_+	PrkA family serine protein kinase	A0MN77	Thermus_phage	2.4e-109	38.4
WP_025039066.1\|485040_486198_+	sporulation protein YhbH	A0A140HLI1	Bacillus_phage	1.1e-24	45.3
WP_023634418.1\|486274_486985_-	hypothetical protein	NA	NA	NA	NA
WP_011230062.1\|487920_488601_-	response regulator	W8CYM9	Bacillus_phage	4.6e-07	26.4
WP_011230063.1\|488664_490242_-	sensor histidine kinase	W8CYF6	Bacillus_phage	9.7e-08	25.6
WP_062898385.1\|490555_491596_+	TRAP transporter substrate-binding protein	NA	NA	NA	NA
WP_025039067.1\|491756_493019_+	dicarboxylate/amino acid:cation symporter	NA	NA	NA	NA
WP_011230066.1\|493301_494129_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	5.7e-76	52.0
WP_011230067.1\|494275_494968_+	zinc metallopeptidase	NA	NA	NA	NA
WP_011230068.1\|495079_496420_+	HlyC/CorC family transporter	NA	NA	NA	NA
WP_011230069.1\|496494_497394_-	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_014194938.1\|497532_497931_+	YhcU family protein	NA	NA	NA	NA
WP_011230071.1\|498256_498730_-	thioredoxin family protein	NA	NA	NA	NA
WP_011230072.1\|498726_499164_-	disulfide bond formation protein B	NA	NA	NA	NA
WP_011230073.1\|499337_499784_+	CBS domain-containing protein	A0A2I6B2H4	Macacine_betaherpesvirus	3.0e-15	39.7
WP_011230074.1\|499900_501658_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	5.5e-161	49.7
WP_013146280.1\|501705_501963_-	hypothetical protein	NA	NA	NA	NA
WP_025039331.1\|502143_502392_+	hypothetical protein	NA	NA	NA	NA
WP_011230077.1\|502421_503027_-	DedA family protein	NA	NA	NA	NA
WP_062898386.1\|503128_504502_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_062898387.1\|504505_505198_-	response regulator transcription factor	W8CYM9	Bacillus_phage	7.2e-32	35.1
WP_062898388.1\|505312_506632_-	hypothetical protein	NA	NA	NA	NA
WP_062898389.1\|506869_507487_+	undecaprenyl-diphosphatase	NA	NA	NA	NA
WP_062898390.1\|508688_510560_+	AAA family ATPase	NA	NA	NA	NA
WP_011229674.1\|510985_511549_+\|transposase	transposase	NA	NA	NA	NA
WP_062898392.1\|512253_513621_-\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_011229854.1\|514648_515449_+	AAA family ATPase	NA	NA	NA	NA
WP_011230285.1\|518085_519591_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_011230286.1\|519587_520340_+	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	8.7e-39	41.4
WP_062898395.1\|521073_521397_+	recombinase family protein	NA	NA	NA	NA
WP_062898396.1\|521661_522387_-	iron permease	NA	NA	NA	NA
WP_062898397.1\|522704_523133_+	hypothetical protein	NA	NA	NA	NA
WP_082816469.1\|523147_523576_+	hypothetical protein	A0A1X9I5T2	Streptococcus_phage	7.9e-29	47.7
WP_062898399.1\|523757_524846_-	hypothetical protein	NA	NA	NA	NA
WP_062898400.1\|524842_525394_-	copper resistance protein CopC	NA	NA	NA	NA
WP_062898401.1\|525591_526065_+	hypothetical protein	NA	NA	NA	NA
WP_062898402.1\|526208_526931_+	ZIP family metal transporter	NA	NA	NA	NA
WP_062898403.1\|527094_528459_-	MATE family efflux transporter	NA	NA	NA	NA
WP_020754474.1\|528471_528777_-	metal-sensing transcriptional repressor	NA	NA	NA	NA
WP_062898404.1\|529346_530243_-	cation transporter	NA	NA	NA	NA
WP_062898405.1\|530392_530701_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_062898406.1\|530716_531664_+	cation transporter	NA	NA	NA	NA
WP_062898407.1\|532237_533140_+	hypothetical protein	NA	NA	NA	NA
WP_062898408.1\|533494_534061_-	cupin domain-containing protein	Q2I8C5	Bacillus_phage	5.0e-55	71.9
WP_062898409.1\|534990_536649_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_062898410.1\|538309_538975_-	haloacid dehalogenase type II	NA	NA	NA	NA
WP_062898411.1\|539269_539713_-	OsmC family protein	NA	NA	NA	NA
WP_062898412.1\|540010_540241_-	glutaredoxin family protein	NA	NA	NA	NA
WP_062898413.1\|540371_541043_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_011229816.1\|541154_542345_+\|transposase	ISL3 family transposase	A0A0A8WEF4	Clostridium_phage	2.2e-28	25.2

DBSCAN-SWA_4

693356 : 754804

Streptococcus_phage(25.0%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_100664207.1\|693356_694145_-\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_014195072.1\|695177_695669_-	YajQ family cyclic di-GMP-binding protein	NA	NA	NA	NA
WP_014195073.1\|695961_696621_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_062898451.1\|696628_697831_+	CoA transferase	NA	NA	NA	NA
WP_062898452.1\|697833_698733_+	hydroxymethylglutaryl-CoA lyase	NA	NA	NA	NA
WP_062898453.1\|698729_699770_+	DctP family TRAP transporter solute-binding subunit	NA	NA	NA	NA
WP_015374098.1\|699826_700324_+	TRAP transporter small permease	NA	NA	NA	NA
WP_062898454.1\|700320_701598_+	TRAP transporter large permease	NA	NA	NA	NA
WP_008879040.1\|701650_701782_-	DUF3941 domain-containing protein	NA	NA	NA	NA
WP_062898455.1\|702016_703111_+	Fic family protein	D7RWK9	Brochothrix_phage	1.6e-49	35.8
WP_062898456.1\|703167_704031_-	DegV family protein	NA	NA	NA	NA
WP_014195081.1\|704209_704410_-	DUF3813 domain-containing protein	NA	NA	NA	NA
WP_011230248.1\|704412_704565_-	hypothetical protein	NA	NA	NA	NA
WP_014195082.1\|704910_705717_-	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_011230250.1\|705833_706601_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_011230251.1\|706803_707175_+	helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	1.6e-41	64.1
WP_011230252.1\|707164_709291_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.3e-244	63.3
WP_015374108.1\|709528_709774_+	hypothetical protein	NA	NA	NA	NA
WP_011230254.1\|709871_710618_-	Fic family protein	NA	NA	NA	NA
WP_011230255.1\|710811_711114_-	metal-sulfur cluster assembly factor	NA	NA	NA	NA
WP_062898457.1\|711136_712387_-	hypothetical protein	NA	NA	NA	NA
WP_013146125.1\|712383_712593_-	DUF2249 domain-containing protein	NA	NA	NA	NA
WP_014195085.1\|712596_712830_-	DUF2249 domain-containing protein	NA	NA	NA	NA
WP_011230259.1\|713067_713760_-	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_062898458.1\|713992_716356_+	nitric-oxide reductase large subunit	NA	NA	NA	NA
WP_062898459.1\|716685_717537_-	hypothetical protein	NA	NA	NA	NA
WP_011230263.1\|717992_718160_-	hypothetical protein	NA	NA	NA	NA
WP_013523134.1\|718289_718523_+	DUF2249 domain-containing protein	NA	NA	NA	NA
WP_033007367.1\|718628_719210_+	molybdenum cofactor guanylyltransferase	NA	NA	NA	NA
WP_062898460.1\|719874_720993_+	radical SAM/SPASM domain-containing protein	NA	NA	NA	NA
WP_062898461.1\|721352_722102_-	anti-sigma factor	NA	NA	NA	NA
WP_023633802.1\|722091_722673_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_014195097.1\|722800_723967_+	hypothetical protein	NA	NA	NA	NA
WP_021322319.1\|723969_724926_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	3.2e-30	33.0
WP_023633804.1\|724912_725992_+	ABC transporter permease	NA	NA	NA	NA
WP_062898462.1\|726271_727447_+	NarK/NasA family nitrate transporter	NA	NA	NA	NA
WP_162924022.1\|728279_729005_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_023633814.1\|729214_729877_+	molybdate ABC transporter permease subunit	NA	NA	NA	NA
WP_023633815.1\|729931_730957_+	GTP 3',8-cyclase MoaA	NA	NA	NA	NA
WP_020279770.1\|731044_731752_-	iron-sulfur cluster repair di-iron protein	NA	NA	NA	NA
WP_020279769.1\|732040_732997_+	methyl-accepting chemotaxis sensory transducer	A0A2H4J162	uncultured_Caudovirales_phage	3.9e-12	45.8
WP_020279768.1\|733046_734306_+	molybdopterin molybdotransferase MoeA	NA	NA	NA	NA
WP_021321985.1\|734302_734803_+	molybdopterin-guanine dinucleotide biosynthesis protein B	NA	NA	NA	NA
WP_033027975.1\|734799_735267_+	molybdenum cofactor biosynthesis protein MoaE	NA	NA	NA	NA
WP_047757638.1\|735263_735494_+	molybdopterin converting factor subunit 1	NA	NA	NA	NA
WP_023633821.1\|735499_736228_+	YwiC-like family protein	NA	NA	NA	NA
WP_062898466.1\|737945_739394_+\|transposase	IS66-like element ISBst12 family transposase	NA	NA	NA	NA
WP_011230285.1\|744900_746406_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_011230286.1\|746402_747155_+	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	8.7e-39	41.4
WP_015374552.1\|749005_750050_-\|transposase	IS630-like element ISBs2 family transposase	S5VXX4	Leptospira_phage	1.6e-27	27.5
WP_023633323.1\|750655_751201_-	hypothetical protein	NA	NA	NA	NA
WP_023633822.1\|751520_753188_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_062898467.1\|753255_753531_+	hypothetical protein	NA	NA	NA	NA
WP_011229816.1\|753613_754804_+\|transposase	ISL3 family transposase	A0A0A8WEF4	Clostridium_phage	2.2e-28	25.2

DBSCAN-SWA_5

930966 : 939108

Streptococcus_virus(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_031206548.1\|930966_931638_+	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	3.9e-67	57.5
WP_011230477.1\|931634_932072_+	6-carboxytetrahydropterin synthase QueD	A0A1U9WRB3	Streptococcus_virus	9.6e-06	33.0
WP_011230478.1\|932071_932806_+	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	3.8e-55	44.6
WP_011230479.1\|932858_933356_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	7.7e-52	67.9
WP_014195299.1\|933409_934093_+	NAD(P)H-binding protein	NA	NA	NA	NA
WP_013145942.1\|934123_934303_-	YkvS family protein	NA	NA	NA	NA
WP_014195301.1\|934604_935189_-	LysM peptidoglycan-binding domain-containing protein	U5PWL4	Bacillus_phage	1.4e-41	50.0
WP_011230483.1\|935389_935584_-	hypothetical protein	NA	NA	NA	NA
WP_011230484.1\|935755_936430_+	hypothetical protein	NA	NA	NA	NA
WP_023634225.1\|936699_937449_+	glucose 1-dehydrogenase	Q06VL0	Trichoplusia_ni_ascovirus	7.1e-17	31.2
WP_011230486.1\|937514_937760_+	hypothetical protein	NA	NA	NA	NA
WP_011230487.1\|937815_939108_+	PAS domain-containing protein	A0A1V0SGX0	Hokovirus	2.1e-16	26.0

DBSCAN-SWA_6

1317309 : 1401147

Wolbachia_phage(33.33%)

tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062898553.1\|1317309_1318365_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	D5GVD0	Campylobacter_virus	1.4e-05	22.4
WP_062898554.1\|1319260_1320247_+	restriction endonuclease	NA	NA	NA	NA
WP_011230887.1\|1320317_1321622_-	acetamidase/formamidase family protein	NA	NA	NA	NA
WP_014195569.1\|1321841_1322051_+	hypothetical protein	NA	NA	NA	NA
WP_011230888.1\|1322016_1323429_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_011230891.1\|1324792_1325284_+	hypothetical protein	NA	NA	NA	NA
WP_062898555.1\|1325693_1327199_+	malate:quinone oxidoreductase	NA	NA	NA	NA
WP_062899090.1\|1327548_1328097_+	YpiB family protein	NA	NA	NA	NA
WP_062898556.1\|1328202_1329330_-	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_062898557.1\|1329579_1330419_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_013523504.1\|1330875_1331526_+	DUF975 family protein	NA	NA	NA	NA
WP_062898558.1\|1331642_1333010_-	short-chain fatty acid transporter	NA	NA	NA	NA
WP_062898559.1\|1333156_1334758_-	acyl--CoA ligase	A0A1V0SBX8	Catovirus	5.8e-16	26.0
WP_062898560.1\|1334777_1335551_-	glucose 1-dehydrogenase	NA	NA	NA	NA
WP_062899091.1\|1335723_1337067_-	sigma 54-interacting transcriptional regulator	NA	NA	NA	NA
WP_062898561.1\|1337298_1338510_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_062898562.1\|1340153_1341815_-	hypothetical protein	NA	NA	NA	NA
WP_014195581.1\|1341830_1342352_-	RNA polymerase sigma factor	NA	NA	NA	NA
WP_062898563.1\|1342607_1343090_+	DUF2935 domain-containing protein	NA	NA	NA	NA
WP_011230901.1\|1343146_1343464_+	YbjQ family protein	NA	NA	NA	NA
WP_011230902.1\|1343657_1343966_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_011230903.1\|1343983_1344907_+	cation transporter	NA	NA	NA	NA
WP_033025188.1\|1344937_1345834_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_062898564.1\|1346063_1347893_+	assimilatory sulfite reductase (NADPH) flavoprotein subunit	NA	NA	NA	NA
WP_020278761.1\|1347919_1349641_+	assimilatory sulfite reductase (NADPH) hemoprotein subunit	NA	NA	NA	NA
WP_062898565.1\|1349998_1351465_+	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_062898566.1\|1352560_1353205_-	hypothetical protein	NA	NA	NA	NA
WP_062898567.1\|1353374_1357142_+	AAA family ATPase	NA	NA	NA	NA
WP_023634510.1\|1357699_1359133_+	site-specific DNA-methyltransferase	A0A2K5B2C1	Erysipelothrix_phage	3.1e-109	45.0
WP_062898568.1\|1359234_1359546_-	hypothetical protein	NA	NA	NA	NA
WP_013523518.1\|1359810_1361319_-	NCS1 family nucleobase:cation symporter-1	NA	NA	NA	NA
WP_013523519.1\|1361665_1362556_+	apolipoprotein acyltransferase	M1HUK8	Acanthocystis_turfacea_Chlorella_virus	7.3e-45	37.2
WP_031206329.1\|1362624_1363980_+	NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_011230918.1\|1363999_1365289_+	NAD-dependent dihydropyrimidine dehydrogenase subunit PreA	NA	NA	NA	NA
WP_011230919.1\|1365307_1366723_+	dihydropyrimidinase	NA	NA	NA	NA
WP_011230920.1\|1366802_1367033_+	hypothetical protein	NA	NA	NA	NA
WP_062898569.1\|1367339_1368968_+	PucR family transcriptional regulator	NA	NA	NA	NA
WP_062898570.1\|1369158_1370292_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_011230922.1\|1370510_1371977_+	CoA-acylating methylmalonate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_062898571.1\|1372006_1373359_+	aspartate aminotransferase family protein	NA	NA	NA	NA
WP_031212882.1\|1374397_1375384_+	acryloyl-CoA reductase	NA	NA	NA	NA
WP_011230926.1\|1375685_1376597_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_047757825.1\|1376722_1381282_+	glutamate synthase large subunit	NA	NA	NA	NA
WP_011230928.1\|1381428_1382913_+	glutamate synthase subunit beta	NA	NA	NA	NA
WP_020278734.1\|1383125_1383710_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_062898572.1\|1383877_1384666_+	ATP-binding protein	NA	NA	NA	NA
WP_062898573.1\|1384817_1386911_+	DUF2157 domain-containing protein	NA	NA	NA	NA
WP_042381822.1\|1386935_1387808_-	phosphotransferase	NA	NA	NA	NA
WP_042381819.1\|1387804_1388533_-	NAD-dependent deacylase	S5M4R0	Bacillus_phage	3.4e-48	44.1
WP_023634140.1\|1388678_1389230_+	DJ-1/PfpI family protein	NA	NA	NA	NA
WP_023634139.1\|1389385_1390279_-	DMT family transporter	NA	NA	NA	NA
WP_014195615.1\|1390592_1392029_+	NAD-dependent malic enzyme	NA	NA	NA	NA
WP_011230937.1\|1392174_1392930_+	SIS domain-containing protein	NA	NA	NA	NA
WP_013145591.1\|1393009_1393234_+	hypothetical protein	NA	NA	NA	NA
WP_011230938.1\|1393700_1394435_+	sporulation protein	A0A0E3T7R5	Bacillus_phage	1.9e-38	64.0
WP_020959521.1\|1394633_1395770_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	3.3e-42	29.4
WP_020959521.1\|1396176_1397313_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	3.3e-42	29.4
WP_062898574.1\|1397719_1398856_-\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	9.4e-45	29.9
WP_110107839.1\|1399269_1399551_+	MFS transporter	NA	NA	NA	NA
WP_062898576.1\|1400091_1401147_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	NA	NA	NA	NA

DBSCAN-SWA_7

2180716 : 2190564

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_162832688.1\|2180716_2181811_-	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	3.7e-22	33.6
WP_033012345.1\|2182214_2183528_-	superoxide dismutase	Q56AR7	Bacillus_thuringiensis_phage	5.2e-39	43.6
WP_011231771.1\|2183885_2184287_-	hypothetical protein	NA	NA	NA	NA
WP_011231772.1\|2184305_2184959_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	1.7e-14	35.3
WP_020278275.1\|2185134_2185890_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	9.4e-09	24.5
WP_011231774.1\|2186084_2186624_+	DUF309 domain-containing protein	NA	NA	NA	NA
WP_011231775.1\|2186646_2187003_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_011231776.1\|2187123_2187588_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.0e-42	61.1
WP_014196246.1\|2187608_2188802_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.5e-117	54.1
WP_011231778.1\|2188822_2189467_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.9e-39	41.3
WP_014196247.1\|2189421_2190564_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	2.0e-55	36.3

DBSCAN-SWA_8

2260699 : 2267140

Geobacillus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011231867.1\|2260699_2261428_-	glycerophosphodiester phosphodiesterase	M1HTS7	Paramecium_bursaria_Chlorella_virus	5.3e-17	28.7
WP_011231868.1\|2261537_2261690_+	YycC family protein	NA	NA	NA	NA
WP_062898766.1\|2262109_2262343_-	hypothetical protein	NA	NA	NA	NA
WP_062898767.1\|2262843_2263059_+	helix-turn-helix transcriptional regulator	A0A0C5ABM0	Bacteriophage	6.5e-08	36.6
WP_062898768.1\|2263070_2263754_-	hypothetical protein	Q0H249	Geobacillus_phage	3.5e-31	38.3
WP_062898769.1\|2263740_2264880_-	DNA translocase FtsK	Q0H250	Geobacillus_phage	2.1e-89	46.6
WP_062898770.1\|2264889_2265231_-	hypothetical protein	NA	NA	NA	NA
WP_062898771.1\|2265223_2265580_-	hypothetical protein	NA	NA	NA	NA
WP_156484080.1\|2265705_2265849_-	hypothetical protein	NA	NA	NA	NA
WP_062898772.1\|2266107_2266326_-	hypothetical protein	A0A1U9WQK5	Geobacillus_phage	3.9e-08	67.4
WP_062898773.1\|2266312_2267140_-	ParM/StbA family protein	E5DV70	Deep-sea_thermophilic_phage	3.2e-63	48.2

DBSCAN-SWA_9

2273101 : 2283942

Bacillus_phage(25.0%)

capsid,terminase,portal,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_061912175.1\|2273101_2273425_-	HK97 gp10 family phage protein	H9YRP8	environmental_Halophage	2.0e-08	52.4
WP_062898779.1\|2273424_2273742_-	hypothetical protein	NA	NA	NA	NA
WP_082816482.1\|2273738_2273978_-	hypothetical protein	NA	NA	NA	NA
WP_062898523.1\|2274054_2275242_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_156484081.1\|2275419_2275578_-	hypothetical protein	NA	NA	NA	NA
WP_062898780.1\|2275643_2276456_-	hypothetical protein	A0A0A7AQF5	Bacillus_phage	5.0e-101	67.0
WP_062898781.1\|2276535_2277153_-	DUF4355 domain-containing protein	A0A1L2K2N1	Aeribacillus_phage	7.3e-36	46.7
WP_062898782.1\|2277269_2278127_-\|capsid	minor capsid protein	D2J057	Enterococcus_phage	4.9e-22	30.7
WP_062898783.1\|2278119_2279397_-\|portal	phage portal protein	I1TJV4	Clostridium_phage	3.6e-77	38.9
WP_082816483.1\|2279412_2281002_-\|terminase	phage terminase large subunit	A0A0N7AEF1	Bacillus_phage	1.8e-94	37.5
WP_061912188.1\|2281151_2281739_-	recombinase family protein	A0A1V0E035	Clostridioides_phage	9.5e-25	41.6
WP_061912189.1\|2281863_2282277_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_062898784.1\|2282403_2282730_-	hypothetical protein	NA	NA	NA	NA
WP_062898785.1\|2282792_2282981_-	hypothetical protein	NA	NA	NA	NA
WP_062898786.1\|2282967_2283192_-	hypothetical protein	NA	NA	NA	NA
WP_062898787.1\|2283210_2283411_-	hypothetical protein	NA	NA	NA	NA
WP_156484082.1\|2283415_2283568_-	hypothetical protein	NA	NA	NA	NA
WP_062898788.1\|2283624_2283942_-	hypothetical protein	A0A0A8WJ72	Clostridium_phage	2.8e-15	38.8

DBSCAN-SWA_10

2985811 : 2994724

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062898930.1\|2985811_2987452_-	mercury(II) reductase	A0A2K5B2C5	Erysipelothrix_phage	2.9e-47	29.2
WP_074043093.1\|2987523_2987835_-	transporter	NA	NA	NA	NA
WP_062898931.1\|2988232_2989531_-	peptidoglycan DD-metalloendopeptidase family protein	A0A222YZS8	Streptomyces_phage	1.8e-15	44.5
WP_062898932.1\|2989560_2990454_-	ABC transporter permease	NA	NA	NA	NA
WP_011232571.1\|2990434_2991130_-	cell division ATP-binding protein FtsE	G9BWD6	Planktothrix_phage	7.0e-27	36.3
WP_062898933.1\|2991626_2991962_-	cytochrome c	NA	NA	NA	NA
WP_062898934.1\|2992023_2992887_-	YitT family protein	NA	NA	NA	NA
WP_062898935.1\|2993023_2993284_-	type II toxin-antitoxin system RelE/ParE family toxin	A0A125RQ76	Bacillus_phage	1.6e-29	67.4
WP_062899118.1\|2993252_2993507_-	hypothetical protein	A0A125RQ77	Bacillus_phage	4.1e-17	52.9
WP_167367370.1\|2993622_2994724_-	peptide chain release factor 2	A0A0S4KWG0	Pseudomonas_phage	2.4e-05	39.0

DBSCAN-SWA_11

3068229 : 3123943

Bacillus_phage(25.0%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_062898973.1\|3068229_3069462_-\|protease	serine protease	U5Q0C0	Bacillus_phage	1.2e-16	38.7
WP_062898974.1\|3069682_3070426_+	hypothetical protein	NA	NA	NA	NA
WP_062898975.1\|3070477_3075475_-	amylopullulanase	NA	NA	NA	NA
WP_023633617.1\|3075816_3077466_+	alpha-amylase	NA	NA	NA	NA
WP_062898976.1\|3077563_3079891_-	bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase	NA	NA	NA	NA
WP_021321947.1\|3080275_3081337_+	hypothetical protein	NA	NA	NA	NA
WP_062898977.1\|3081475_3082195_-	hypothetical protein	NA	NA	NA	NA
WP_062899119.1\|3082401_3082866_-	hypothetical protein	NA	NA	NA	NA
WP_062899120.1\|3082947_3083370_-	hypothetical protein	NA	NA	NA	NA
WP_011230286.1\|3084986_3085739_-	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	8.7e-39	41.4
WP_011230285.1\|3085735_3087241_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_062898979.1\|3087892_3088624_-	ATP-binding protein	A0A059NT77	Lactococcus_phage	2.3e-36	39.7
WP_062898980.1\|3088620_3089283_-	hypothetical protein	NA	NA	NA	NA
WP_011229674.1\|3089493_3090057_+\|transposase	transposase	NA	NA	NA	NA
WP_011229672.1\|3090579_3090906_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_011229671.1\|3090902_3091766_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	6.4e-46	41.5
WP_011229854.1\|3092882_3093683_+	AAA family ATPase	NA	NA	NA	NA
WP_062898981.1\|3093925_3094435_-	DNA repair protein RadC	NA	NA	NA	NA
WP_062898982.1\|3094738_3097381_-	hypothetical protein	NA	NA	NA	NA
WP_062898983.1\|3097753_3098533_-	hypothetical protein	NA	NA	NA	NA
WP_062898984.1\|3098578_3099934_-	peptidase P60	A0A0A8WF62	Clostridium_phage	1.4e-15	40.6
WP_011232659.1\|3100116_3100626_-	hypothetical protein	NA	NA	NA	NA
WP_062898985.1\|3100834_3101242_+	helix-turn-helix domain-containing protein	A8ASM2	Listeria_phage	8.0e-07	31.8
WP_025039147.1\|3101362_3101710_-	single-stranded DNA-binding protein	A0A059T5E0	Listeria_phage	1.5e-33	68.0
WP_013146485.1\|3101991_3102432_+	hypothetical protein	NA	NA	NA	NA
WP_014196837.1\|3102488_3103118_-	class D sortase	NA	NA	NA	NA
WP_062898986.1\|3103124_3104024_-	processed acidic surface protein	NA	NA	NA	NA
WP_042379307.1\|3104404_3105781_-	aspartate kinase	NA	NA	NA	NA
WP_025039145.1\|3106058_3106493_-	DUF1284 domain-containing protein	NA	NA	NA	NA
WP_014196843.1\|3106886_3107474_+	hypothetical protein	NA	NA	NA	NA
WP_062898988.1\|3107687_3109208_+	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_062898989.1\|3109416_3109776_+	DUF779 domain-containing protein	NA	NA	NA	NA
WP_062898990.1\|3110100_3111156_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	NA	NA	NA	NA
WP_062898991.1\|3111313_3112921_-	MFS transporter	NA	NA	NA	NA
WP_062898992.1\|3112905_3113829_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_013146496.1\|3113821_3113962_-	hypothetical protein	NA	NA	NA	NA
WP_062898993.1\|3114169_3115042_-	ROK family protein	NA	NA	NA	NA
WP_011232675.1\|3115204_3116026_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_011232676.1\|3116025_3116997_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_014196864.1\|3117058_3118357_-	carbohydrate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_062898994.1\|3118681_3120223_-	response regulator transcription factor	NA	NA	NA	NA
WP_011232679.1\|3120200_3121670_-	sensor histidine kinase	Q9EYF3	Enterobacteria_phage	1.9e-18	32.8
WP_042379337.1\|3121831_3122845_-	sugar-binding protein	NA	NA	NA	NA
WP_023634299.1\|3123064_3123943_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_12

3146547 : 3193899

Bacillus_phage(40.0%)

integrase,transposase

attL 3146481:3146499|attR 3152086:3152104

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
3146481:3146499	attL	NA	NA	NA	NA
WP_011229816.1\|3146547_3147738_-\|transposase	ISL3 family transposase	A0A0A8WEF4	Clostridium_phage	2.2e-28	25.2
WP_062899004.1\|3147754_3148306_+	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_062899005.1\|3149188_3150601_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A1X9I6E7	Streptococcus_phage	2.1e-06	26.6
WP_011229671.1\|3152180_3153044_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	6.4e-46	41.5
3152086:3152104	attR	NA	NA	NA	NA
WP_011229672.1\|3153040_3153367_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_020278768.1\|3153686_3154898_+	MFS transporter	NA	NA	NA	NA
WP_053414193.1\|3154912_3155524_+	hypothetical protein	A0A068EE92	Pigeonpox_virus	3.1e-18	37.3
WP_062899006.1\|3155673_3157068_+	radical SAM protein	NA	NA	NA	NA
WP_062899007.1\|3157842_3159501_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_011232711.1\|3160061_3160262_-	DUF3311 domain-containing protein	NA	NA	NA	NA
WP_062899008.1\|3160298_3161483_-	amidohydrolase	NA	NA	NA	NA
WP_062899009.1\|3161516_3162746_-	Zn-dependent hydrolase	NA	NA	NA	NA
WP_014196895.1\|3162902_3164231_-	hypothetical protein	NA	NA	NA	NA
WP_011232724.1\|3164487_3165861_-	UDP-glucose/GDP-mannose dehydrogenase family protein	A0A127AXI2	Bacillus_phage	5.9e-86	40.6
WP_062899010.1\|3166101_3167442_-	SH3 domain-containing protein	A0A1S5QTQ1	Bacillus_phage	2.2e-16	34.6
WP_080729647.1\|3167854_3168088_-	hypothetical protein	NA	NA	NA	NA
WP_062898523.1\|3168299_3169487_+\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_011232727.1\|3169590_3170301_+	plasmid pRiA4b ORF-3 family protein	A0A2H4PDG5	Mycobacterium_phage	6.1e-26	35.4
WP_014195141.1\|3170387_3171722_-	hypothetical protein	NA	NA	NA	NA
WP_062899011.1\|3172247_3174443_-	hypothetical protein	NA	NA	NA	NA
WP_062899012.1\|3174740_3176057_-	SEC-C domain-containing protein	NA	NA	NA	NA
WP_082816489.1\|3176249_3177917_+	hypothetical protein	NA	NA	NA	NA
WP_062899013.1\|3177913_3180673_+	DEAD/DEAH box helicase	E7DNC5	Pneumococcus_phage	5.8e-32	25.8
WP_011232734.1\|3181286_3182258_-	DUF1861 family protein	NA	NA	NA	NA
WP_023634280.1\|3182538_3183024_-	Appr-1-p processing protein	G3MBI4	Bacillus_virus	4.9e-43	55.5
WP_011232736.1\|3183027_3183405_-	DUF488 family protein	NA	NA	NA	NA
WP_011232737.1\|3183426_3183858_-	hypothetical protein	NA	NA	NA	NA
WP_011232738.1\|3183860_3185174_-	AAA family ATPase	NA	NA	NA	NA
WP_011232739.1\|3185216_3186104_-	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	1.1e-77	52.7
WP_062899014.1\|3186385_3187444_-	glycosidase	NA	NA	NA	NA
WP_062899015.1\|3187446_3188394_-	DUF1861 family protein	NA	NA	NA	NA
WP_062899016.1\|3188435_3189266_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_011232743.1\|3189252_3190131_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_014195126.1\|3190132_3191458_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_033012646.1\|3191952_3192966_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_011232746.1\|3193005_3193899_-\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP014336

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP014335

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection