CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP014870	Pseudomonas silesiensis strain A3 chromosome, complete genome	17 crisprs	DEDDh,DinG,PD-DExK,cas3,csa3	3	0	4	0

1. NZ_CP014870

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP014870_1

• CRISPR_ID: NZ_CP014870_1
• CRISPR_location: 608189-608278
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_1

Consensus_repeat	Method
TGAAGACGCCTTCGCCGGCAAGCC	CRISPRCasFinder

spacers of NZ_CP014870_1

>1.1|608213|42|NZ_CP014870|CRISPRCasFinder
TGGCTCCTACGGTGAAGGCGGCTTCAAGCCTTGAGCCGCTTG

CRISPR arrays and Neighbor proteins around NZ_CP014870_1

CRISPR arrays

The CRISPR arrays of NZ_CP014870_1

>merge|NZ_CP014870|1|608189-608278|CRISPRCasFinder
TGAAGACGCCTTCGCCGGCAAGCCTGGCTCCTACGGTGAAGGCGGCTTCAAGCCTTGAGCCGCTTGTGAAGACGCCTTCGCTGGCAAGCC

>NZ_CP014870|1|1|608189-608278|CRISPRCasFinder
TGAAGACGCCTTCGCCGGCAAGCC	TGGCTCCTACGGTGAAGGCGGCTTCAAGCCTTGAGCCGCTTG
TGAAGACGCCTTCGCTGGCAAGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064675721.1|614561_615353_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|380379
NZ_CP014870.1|WP_064675716.1|609417_610041_+|DUF4136-domain-containing-protein	unknown	unknown	gnl|CDD|379281
NZ_CP014870.1|WP_064675718.1|610663_611518_-|acyl-dehydratase	unknown	unknown	gnl|CDD|366711
NZ_CP014870.1|WP_064675709.1|601937_603851_+|arginine-decarboxylase	unknown	unknown	gnl|CDD|235427
NZ_CP014870.1|WP_064675720.1|613092_614370_+|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|236440
NZ_CP014870.1|WP_064675719.1|611520_612873_-|3-oxoacyl-ACP-reductase	unknown	unknown	gnl|CDD|236207
NZ_CP014870.1|WP_064675712.1|606201_607551_-|MATE-family-efflux-transporter	unknown	unknown	gnl|CDD|240541
NZ_CP014870.1|WP_064675711.1|605390_606173_+|DUF4123-domain-containing-protein	unknown	unknown	gnl|CDD|379225
NZ_CP014870.1|WP_064680604.1|616443_617049_-|hypothetical-protein	unknown	unknown	gnl|CDD|225527
NZ_CP014870.1|WP_064675714.1|608353_608656_+|pyrophosphatase	unknown	unknown	gnl|CDD|212144
NZ_CP014870.1|WP_064675705.1|595468_597415_-|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl|CDD|223910
NZ_CP014870.1|WP_064675707.1|599425_600493_+|DUF2333-family-protein	unknown	unknown	gnl|CDD|378387
NZ_CP014870.1|WP_064675713.1|607727_608021_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064675706.1|597467_599138_-|diguanylate-cyclase	unknown	unknown	gnl|CDD|226229
NZ_CP014870.1|WP_064675715.1|608655_609405_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|182918
NZ_CP014870.1|WP_064675722.1|615366_616404_-|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl|CDD|235511
NZ_CP014870.1|WP_064675710.1|604083_605394_+|type-VI-secretion-protein	unknown	unknown	gnl|CDD|274542
NZ_CP014870.1|WP_064675717.1|610091_610646_+|DUF4136-domain-containing-protein	unknown	unknown	gnl|CDD|379281
NZ_CP014870.1|WP_033059567.1|601352_601724_+|translation-initiation-factor-Sui1	unknown	unknown	gnl|CDD|168689
NZ_CP014870.1|WP_064675708.1|600496_601057_+|NUDIX-hydrolase	unknown	unknown	gnl|CDD|240053

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064675721.1|614561_615353_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|380379	cd06124, cupin_NimR-like_N, AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain. This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	3.5558e-29
NZ_CP014870.1|WP_064675716.1|609417_610041_+|DUF4136-domain-containing-protein	gnl|CDD|379281	pfam13590, DUF4136, Domain of unknown function (DUF4136). This domain is found in bacterial lipoproteins. The function is not known.	1.96759e-26
NZ_CP014870.1|WP_064675718.1|610663_611518_-|acyl-dehydratase	gnl|CDD|366711	pfam01575, MaoC_dehydratas, MaoC like domain. The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity. This domain is also present in the NodN nodulation protein N.	8.60345e-14
NZ_CP014870.1|WP_064675709.1|601937_603851_+|arginine-decarboxylase	gnl|CDD|235427	PRK05354, PRK05354, biosynthetic arginine decarboxylase.	0
NZ_CP014870.1|WP_064675720.1|613092_614370_+|acetyl-CoA-C-acetyltransferase	gnl|CDD|236440	PRK09268, PRK09268, acetyl-CoA C-acetyltransferase.	0
NZ_CP014870.1|WP_064675719.1|611520_612873_-|3-oxoacyl-ACP-reductase	gnl|CDD|236207	PRK08261, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional.	0
NZ_CP014870.1|WP_064675705.1|595468_597415_-|methyl-accepting-chemotaxis-protein	gnl|CDD|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	2.2338e-57
NZ_CP014870.1|WP_064675711.1|605390_606173_+|DUF4123-domain-containing-protein	gnl|CDD|379225	pfam13503, DUF4123, Domain of unknown function (DUF4123). This presumed domain is functionally uncharacterized. It is about 120 amino acids in length and contains several conserved motifs that may be functionally important. This domain is sometimes associated with the FHA domain.	2.31082e-10
NZ_CP014870.1|WP_064680604.1|616443_617049_-|hypothetical-protein	gnl|CDD|225527	COG2980, RlpB, Rare lipoprotein B [Cell envelope biogenesis, outer membrane].	5.16134e-30
NZ_CP014870.1|WP_064675714.1|608353_608656_+|pyrophosphatase	gnl|CDD|212144	cd11537, NTP-PPase_RS21-C6_like, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs. RS21-C6 proteins, highly expressed in all vertebrate genomes and green plants, act as house-cleaning enzymes, removing 5-methyl dCTP (m5dCTP) in order to prevent gene silencing. They show significant sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, RS21-C6 contains a single MazG-like domain and functions as a tetramer (a dimer of dimers) with a typical four-helical bundle. Divalent ions, such as Mg2+, are required for its pyrophosphatase activity. This family also includes a pyrophosphatase from Archaeoglobus fulgidus (Af1178). Although its biological role remains unclear, Af1178 shows significant sequence similarity to the mouse RS21-C6 protein.	8.68711e-34
NZ_CP014870.1|WP_064675707.1|599425_600493_+|DUF2333-family-protein	gnl|CDD|378387	pfam10095, DUF2333, Uncharacterized protein conserved in bacteria (DUF2333). Members of this family of hypothetical bacterial proteins have no known function.	0
NZ_CP014870.1|WP_064675712.1|606201_607551_-|MATE-family-efflux-transporter	gnl|CDD|240541	cd13136, MATE_DinF_like, DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	2.01268e-124
NZ_CP014870.1|WP_064675706.1|597467_599138_-|diguanylate-cyclase	gnl|CDD|226229	COG3706, PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms].	2.65482e-100
NZ_CP014870.1|WP_064675715.1|608655_609405_+|methyltransferase-domain-containing-protein	gnl|CDD|182918	PRK11036, PRK11036, tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM.	4.78883e-73
NZ_CP014870.1|WP_064675722.1|615366_616404_-|DNA-polymerase-III-subunit-delta	gnl|CDD|235511	PRK05574, holA, DNA polymerase III subunit delta; Reviewed.	1.39842e-146
NZ_CP014870.1|WP_064675710.1|604083_605394_+|type-VI-secretion-protein	gnl|CDD|274542	TIGR03361, VI_Rhs_Vgr, type VI secretion system Vgr family protein. Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.	6.27849e-54
NZ_CP014870.1|WP_064675717.1|610091_610646_+|DUF4136-domain-containing-protein	gnl|CDD|379281	pfam13590, DUF4136, Domain of unknown function (DUF4136). This domain is found in bacterial lipoproteins. The function is not known.	2.41237e-42
NZ_CP014870.1|WP_033059567.1|601352_601724_+|translation-initiation-factor-Sui1	gnl|CDD|168689	PRK06824, PRK06824, translation initiation factor Sui1; Validated.	1.21289e-70
NZ_CP014870.1|WP_064675708.1|600496_601057_+|NUDIX-hydrolase	gnl|CDD|240053	cd04697, Nudix_Hydrolase_38, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.66859e-58

Protein sequences

>NZ_CP014870.1|WP_064675713.1|607727_608021_-|hypothetical-protein
MQVESFFEWLGQVLGSIIRFIVDALSGLFNLLSNAGSNFVEGLSRALGMDASIISIIALIVGLMLLWAAIRAFMSASIIMGIIWLLLGLWLLSWIIH
>NZ_CP014870.1|WP_064675712.1|606201_607551_-|MATE-family-efflux-transporter
MSNLIADWRDRPTHRRVWALAAPMILSNISVPLVALVDSTVIGHLPHAHQLGAVAVGATLYTFLAWAMGFLRMGSTGFAAQAAGRGDGAALRQILLQGLLLAMGLAIVLGALGVPLSGVALHFMQPSAELDQLTREFFHTRLFGLPAALASYALVGWFLGTQNARAPLAILLSTNLVNIALNLWFVLGLEWGVVGAARASVIAEWTGAVIGLLMTRNALRAYPGHIAWAALALWQSWRPLLAVNRDIFIRSLVLQSVFFLITVQGARLGDATVAANALLLNGLLLTAHALDGLAHAVEALCGHAIGARDRDALRRSLVVACGWSLLASLGFAALFLFAGHLFIEMQTDIQSVRDTAFIYLPYLAALPLIAVWSYLLDGLFIGATRAREMRNGMLLTMILILPFAWALQGLGNHGLWITFLWFMVLRSLTLGAFAWFLRKNDGWFTGRTH
>NZ_CP014870.1|WP_064675711.1|605390_606173_+|DUF4123-domain-containing-protein
MIAASPQWLLLDVPGAPRAGATLRQTFAHARWFWLFEDTELHASREQGPVLVDLGSCPALAGLCYSEAQDWRGLLVFSAASLSPLLAHLRRMLTVTVGVHHRALLNYYNPNTASYIFDACDARELSRWLGPISQLHWFGGTWADRAIGCQSWQQLHNPGLAVSPLAIEESLSPGQQGKLQTCLLEQHAWHWSQSTGTDYNRLWSHLQEGLALGFNERPVLDEWLWLRLQYPRAALVLPLSGRTQQERLHSLRDRWQTDRH
>NZ_CP014870.1|WP_064675710.1|604083_605394_+|type-VI-secretion-protein
MFDPVNEPSFRLDVAGLSDAFEVLAFTGKEAINEPFAFDVDLLVDDPTLDLASLLYQPVYLHFGPAGHAIHGHLHELVQRDQGPAARLCRVRLGPKLACLAQRFSQRIFSARSVPQILSQVLREHGIAGNDRRFELSGDYPPLDFCTQYRESDLQFLQRLCVEARLNYHFEHHAQGHCVVFGDGQAHFRLGELADFHVDSEQPAVRQFQLQEQRTAQSAKGRTDLATLRSGQLMSLSGHPVAHWNQLWLLTHIEHQGSQDPLAPYSNQISAIHRDAPLVSPHCATKPRMHSLQRAWVVDVEESRPDPSRPVAVQFDWLYQGEGAIPTHCWLPLASELSATDSPLSEGAEVVVSFIEGDPDRPLITGFLHLPKAVEEAEEPRATDDCPPDEGLLRMLRSGEPLMLLCLLPGGGSYTHCAQVFCTCRAATRFGRSGAA
>NZ_CP014870.1|WP_064675709.1|601937_603851_+|arginine-decarboxylase
MSVRRTRKDDGSQWTVADSRSVYGIRHWGAGYFAINDAGRVEVRPNGPASSPIDLFEQVDQLRQSGLSLPLLVRFPDILQDRVRQLTGAFDANIERLEYQSKYTALYPIKVNQQEAVIENIIATQDVSIGLEAGSKPELLAVLALAPKGGTIVCNGYKDREFIRLALMGQKLGHNVFIVIEKESEVALVIEEAASLKVKPQVGLRVRLSSLASSKWADTGGEKSKFGLSAAQLLSVVERFRAAGLDQGIRLLHFHMGSQIANLADYQHGFKEAIRYYGELRNLGLPVDHIDVGGGLGVDYDGTHSRNASSINYDMDDYAGVVVGMLKEFCDAQSLPHPNIFSESGRSLTAHHAMLVVQVTDVEKHNDDVPQIENKEALPETVQWLVDLLGPTDIEMVTETYWRATHYMSDVATQYADGKLTLAEKALAEQCYFAVCRRLHNSLKARQRSHRQVLDELNDKLADKYICNFSVFQSLPDTWAIGQVLPILPLHRLDEEPLRRAVLQDLTCDSDGKIKQYVDEQSIETSLPVHGLNEGEDYLLGIFLVGAYQEILGDMHNLFGDTDSVNIYQNADGSVYHAGIETHDTIEDMLRYVHLSPEELMTHYRDKCASARITAAERTQFLDALRLGLTRSSYLSS
>NZ_CP014870.1|WP_033059567.1|601352_601724_+|translation-initiation-factor-Sui1
MAKKAASFAALGGLVFSTDAGRHCPDCSKPVDACICKQTVIPAGDGIARVRRESKGRGGKTVTTITGVPLAEDALKDLATTLKKRCGTGGALKDGIIEIQGDHVELLLAELIKHGFKAKKSGG
>NZ_CP014870.1|WP_064675708.1|600496_601057_+|NUDIX-hydrolase
MVDSSIDSLREAAHRAASDAEQIAWVDEQDNLLGALVRSELRERGLIGRGTYIMLFNSAGELCVHRRTLSKAIYPGYWDVAAGGMVLATETYAESAARELEEELGVGGVELTAHDHFYFEDTGNRLWCSAFSAVWDGPLILQPEEVVEARFIPIDQVLLEITQKPYCPDSLAALRRYLRSQGPDVA
>NZ_CP014870.1|WP_064675707.1|599425_600493_+|DUF2333-family-protein
MLDWKNRAGSAPERAAEPKSATRSYFGGLLFSRALATLIGLYLLVAVALGWYWSQEPALFPVQQNAQVAAEKEGKQMVIGYTTVETLKSVADTLLTKPGGYISNDRFPPGLWMDNTPSWEYGVLVQVRDLSRALRKDFARSQSQSTEDADLAKAEPRFNFDNKSWVLPSSESEYQEGIKSLSRYQARLSDPSQKSALFYARADNLNNWLGDVGTRLGSLSQRLSASVGRVKLNTALKTEVVAPGQVPQVDEEIVETPWMQIDNVFYEARGQAWALSHLLRAIEVDFADVLAKKNATVSVRQIIRELEASQEPVWSPMILNGSGFGVLANHSLVMANYISRANAAVIDLRQLLNQG
>NZ_CP014870.1|WP_064675706.1|597467_599138_-|diguanylate-cyclase
MTEPEEPSRERLKHHFAQRVIHQARQILEIWQRLQSNEWCNTDLSELSEANLRLLRFAERFEQPEHTQLARLIGQSLQSVDANRGRLNSGLINDLNHLMQRLSRTGLRHGDQLEQTFLPPLRKPIYVMLQDHDRAERLARQLEFFGLSAQSLDSVAAFRSSMAERLPAAIVMDVDFCGAGIGLKLAADAQIGLDEPLPLLFFSLQETDTPTRLAAVRAGGKEFLTGTLEASSLLEKIEVLTCVAQYEPYKVLIIDDSRAQALHTERLLNSAGIVTRTLIEPIRAMAELADFQPDLIILDMYMPACTGTELAKVIRHNDRYVSVPIIYLSAEDDLDKQLDAMSEGGDDFLTKPIKPRHLITTVRNRAARARNLKARMVRDSLTGLYNHTHILQLLEDCSLRARRESKPLSFAMLDIDHFKRVNDSHGHPMGDRVIKSLALFLKQRLRKTDFIGRYGGEEFAIVMPDTDLESAYKVLEEIRQRFAEIHYPAQPQDLWCTFSAGVVELCENSDGLMMASQADEALYRAKHAGRNRVQAARTLKQSAIFSAESTESVMTL
>NZ_CP014870.1|WP_064675705.1|595468_597415_-|methyl-accepting-chemotaxis-protein
MRLKLLTNLNTLLLVAVCVALGATLWWSQKALERPYLLMERYLGLSRQFQDDVARNIEDYLASGDALRLSSGGQAIDRLHNELGELPPALAETLRPSLSNLDEFSKTDLLAAGKLAGDPQALLLQAERELGASLDQLSQYASGNVAYLTPLLAASRHLGKLSLARDKLVSSGRSELAADVEREVSNIRLQAEQLDALPLLGVTASNESSTDDFAAMMGLENTEKTVAEEAGVGLKREFNSLLTRYPSELARTREQIRKRADLSAATHLKIAAVQQAIAGLEPVVRAQHGQIQSEVRLIQGVMIGLILLIALLIDTLQRRLARTLTNLAPALSTWAEGDFSQDIELGKTNRELHDIQASLNRLRAYLVDLVGTIRLNAEQVAGSSRTLAELSHDLHSGAEHQAGDTALIRDSLGELEATIQQVAGDASQAADASRHAGLAVEHGQKVIGLSLTGLHALVGEVQGNAQMIEHLAEESATIGGVLTVIRSIADQTNLLALNAAIEAARAGEMGRGFAVVAEEVRTLAQRTARATAEIQTLIAGLQTAARQSVDGMRAQVEHAEATANQAQAADGALDKIVGAIQTISDTAVRIADITAQQSGAVSEIRDHSERIHQLGGDNLLRIGQGREQGEHLLVLGGRLHTAVQAFRV
>NZ_CP014870.1|WP_064675714.1|608353_608656_+|pyrophosphatase
MNLVELTERLHAIRDRNNWRQFHSPKNLAMAASVEMSELVEIFQWLTEDQSRQLPADKLAHAGQEVGDIVLYLLLLCSELGLDMNEVVRNKLADSERRFS
>NZ_CP014870.1|WP_064675715.1|608655_609405_+|methyltransferase-domain-containing-protein
MSDRHFDQLATRFAEKIYGGAKGAIRLAVLQADLAEILPDRPLRVLDIGAGLGHMSLWLAQRGHQVTLAEPAAPMLEGARQRFADAGQTATFIQAPWQELPGQFTEPYDLVLCHAVLEWLAEPHAILPVLHQLTRPEGWLSLAFYNRDALIYRNLLKGHFRKMRKNDMAGEKQSLTPQQPLDPRELAAQLEGLWRVETQSGVRVFHDYMPVEFQARAELVDLLEMELAHRRHPSFAGLGRYLHWICRPV
>NZ_CP014870.1|WP_064675716.1|609417_610041_+|DUF4136-domain-containing-protein
MKTRSGLLVICLGLAACQGSNPYVATSNPLPPAPPQAANTFDRSAYPAPPRDYGRYRSWAWLDGRLPPGTAWADSAQVAEAVSSALDQRGLRPLHDNRQADLFVSADLRLETRLRQVRDDYGYYGGGYGGYGGYNRYGSGYGVYNTVPIVRTYQEQVVVVQVDLFDAQSGQPVWSSSAETSQRGSQGAQTDAIREAVEKAMSAYPPD
>NZ_CP014870.1|WP_064675717.1|610091_610646_+|DUF4136-domain-containing-protein
MFRRLALLAVAALLSACATQVNHDFDASRDFSAYRSWSWKEPALQYRPDDPRIKSDLTEQRVRQSVADQLDQRGLRPAASGTRGDLSVQTYLIVEERQQQVTTNYGGAWGNPWNGYWGGPMYNETRNVSYKVATIQIDLLDGKDGKLVWRGSDEQMLSHSPNPADRSAAIRETVGRILANYPPR
>NZ_CP014870.1|WP_064675718.1|610663_611518_-|acyl-dehydratase
MTIEWHTLNREPSLTDLYVKAATRRKITGTTLPTTGLRCWITVDPQRLAAYRKVCGFADNGLLPPTYPHILAFALQMQLLTDKTFPFPLLGLIHLGNRIRILRPMGGVNRARVSVQVQNLQPHAKGATFDLVTTLDDQLGVLWEAQSQMLCRGVKLEGEPVEEVLASTLELMEVARWQAPADIGRQYAKVSGDYNPIHLSAVSARLFGFPTAIAHGLWNKARTIAALSEHLPAANVEIAVQFRKPVRLPSEVTLLSSAAGSSGDFQLVGAGDLEHMVGHWRPVA
>NZ_CP014870.1|WP_064675719.1|611520_612873_-|3-oxoacyl-ACP-reductase
MSDRYIDFANSSIGHRLVGALGLPSPVRLERWQAGRLRPVEGALLIGGGPLAEKVGAFANRLTDAIYSYGTEPSMATAWIPGHGPKLKAVVFDASDLVQTDQLKQLREFFQPLIKNLDHGAHLVILGRAPQAMSDPFAASAQRALEGFSRSLAKELRGGGTLQLIQVGEGAENQLEGPLRFFLSPKSAFVSGQVIRLDACTAQVTDWTRPLSGRKALVTGAARGIGASIAETLARDGAEVILLDVPPAKTDLEALAARLGGRGITLDICAEDAAAQLIEQLPDGIDIVVHNAGITRDKTLANMTPEFWDAVLAVNLNAPQVLTKALLDSGTLQDDGRVILLASISGIAGNRGQTNYAASKAGLIGLAQAWAPLLKARGISINAVAPGFIETQMTAHLPFGLREAGRRMSSLGQGGLPQDVAEAVAWLAQPGTGAFTGQALRVCGQSVLGA
>NZ_CP014870.1|WP_064675720.1|613092_614370_+|acetyl-CoA-C-acetyltransferase
MTQPRRVAIIGGNRIPFARSNGPYATASNQAMLTAALEGLIERYNLHGLRIGEVAAGAVLKHSRDFNLTRECVLGSRLSPTTPAYDIQQACGTGLEAALLVANKIALGQIECGIAGGVDTTSDAPIGVNEGLRKILLQANRARTTGDKLKTFLQLRPHHLIPELPRNGEPRTRLSMGEHCELMAQTWEIPRQEQDQLALESHQKLAASYTEGWHNDLMTPFLGLTRDNNLRPDLTLEKLASLKPVFEKSARGTLTAGNSTPLTDGASLVLLGSEEWAKERGLPILAYLRDGEAAAVDFVKGAEGLLMAPVYAVPRLLARNGLTLQDFDYYEIHEAFAAQVLCTLKAWEDPHYCETRLGLAAPLGAIDRSRLNVKGSSLAAGHPFAATGGRIVANLAKLLDAAGKGRGLISICAAGGQGVTAIIER
>NZ_CP014870.1|WP_064675721.1|614561_615353_+|helix-turn-helix-transcriptional-regulator
MPTNGQITLERTIPTLTALPRPLFARVESLNAGSWTPSHRHDWVQFSYAISGVLGVHTAEGSFFAPPQWGIWIPADLDHQVVTSMRAEMRSLYVRREDCLWADGRCRVLEVTPLARELIKRFCLLPVEYPQGDSQEARLVSVLLDQLASLPEVEFSLPLPRHERLLGLCSELLENPEQNVTLQEWAQRLGTSEKTLMRLFQRETGLSFRGWRQRMRLLSSLKWLEEGNSVTNAALSCGYDSTSAFIAAFKGLFGFTPGELFKQ
>NZ_CP014870.1|WP_064675722.1|615366_616404_-|DNA-polymerase-III-subunit-delta
MKLAPAQLAKHLQGPLAPVYIISGDDPLLCQEAADAIRAAARQQGFDERQVFAADASFDWGTLLQAGASMSLFAEKRLLELRLPSGKPGDKGAAAFIEYCSRPAEDTVLLISLPKLDGSAQKTKWGKALVEGQHTQFVQIWPVDANQLPSWIRQRLSQAGLSASQDAVELIAARVEGNLLAAAQEIEKLKLMAEGGQITVETVQAAVADSARFDVFGLTDAILNGEAAHALRMLEGLRGEGVEPPVILWALARELRVLANLSLQYSQGVPLDKAFSAARPPIWDKRKPLMSKALQRYPAQRWAQLLLEAQRIDAQIKGQAAGSPWMSLSRLSLLMAGQRLSLPAE
>NZ_CP014870.1|WP_064680604.1|616443_617049_-|hypothetical-protein
MIKRNLLVMGLAVLLSACGFQLRGTGTTELAIKELDLSARDAYGPTVTQMRQVLESSGVKLYSGAPYKLVLTGEQESQRILSYAGAGRTGEYQLSTVLSYDINGQGNLPLMSDKLEVQKVFIHDGNNLVGSDQEANDARKDIRRELVQRMMLRLQQLTPTQLDQLQQTAEARARAEAAALEAAQKAEAQTPRQSPVELPRQ

Crispr_ID: NZ_CP014870_2

• CRISPR_ID: NZ_CP014870_2
• CRISPR_location: 1058038-1058137
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_2

Consensus_repeat	Method
GCGAAGACGGCCTGCCAGCCAACCTGATTT	CRISPRCasFinder

spacers of NZ_CP014870_2

>2.1|1058068|40|NZ_CP014870|CRISPRCasFinder
TACGAATGTACCCAGAACCCTTGTGGGAGCTGGCTTGCCT

CRISPR arrays and Neighbor proteins around NZ_CP014870_2

CRISPR arrays

The CRISPR arrays of NZ_CP014870_2

>merge|NZ_CP014870|2|1058038-1058137|CRISPRCasFinder
GCGAAGACGGCCTGCCAGCCAACCTGATTTTACGAATGTACCCAGAACCCTTGTGGGAGCTGGCTTGCCTGCGAAGGCGGCCTGCCAGCCAACCTGATTT

>NZ_CP014870|2|2|1058038-1058137|CRISPRCasFinder
GCGAAGACGGCCTGCCAGCCAACCTGATTT	TACGAATGTACCCAGAACCCTTGTGGGAGCTGGCTTGCCT
GCGAAGGCGGCCTGCCAGCCAACCTGATTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064676076.1|1050213_1050912_+|extensin-family-protein	unknown	unknown	gnl|CDD|369129
NZ_CP014870.1|WP_064676089.1|1064598_1064976_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676087.1|1061097_1061445_-|YbaY-family-lipoprotein	unknown	unknown	gnl|CDD|378225
NZ_CP014870.1|WP_010462862.1|1064253_1064463_+|cold-shock-protein	unknown	unknown	gnl|CDD|224197
NZ_CP014870.1|WP_064676073.1|1048190_1048496_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676079.1|1052547_1053192_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379522
NZ_CP014870.1|WP_064676081.1|1054391_1057463_+|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl|CDD|223911
NZ_CP014870.1|WP_064676077.1|1050915_1051536_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676091.1|1065859_1067011_-|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl|CDD|237265
NZ_CP014870.1|WP_064676074.1|1048495_1049356_+|DUF72-domain-containing-protein	unknown	unknown	gnl|CDD|182366
NZ_CP014870.1|WP_064676080.1|1053285_1054386_+|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|273776
NZ_CP014870.1|WP_191637766.1|1051632_1052412_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|377360
NZ_CP014870.1|WP_064676088.1|1061595_1064088_-|glycerol-3-phosphate-1-O-acyltransferase-PlsB	unknown	unknown	gnl|CDD|235325
NZ_CP014870.1|WP_064676084.1|1059294_1059693_-|YbaY-family-lipoprotein	unknown	unknown	gnl|CDD|378225
NZ_CP014870.1|WP_064676083.1|1058581_1059271_-|DUF4197-domain-containing-protein	unknown	unknown	gnl|CDD|379394
NZ_CP014870.1|WP_064676086.1|1060415_1061042_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676090.1|1065050_1065860_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|236841
NZ_CP014870.1|WP_064676085.1|1059963_1060311_-|YbaY-family-lipoprotein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676075.1|1049389_1050211_+|isocitrate-lyase/phosphoenolpyruvate-mutase-family-protein	unknown	unknown	gnl|CDD|379346
NZ_CP014870.1|WP_064676072.1|1047321_1047996_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	unknown	unknown	gnl|CDD|274750

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064676076.1|1050213_1050912_+|extensin-family-protein	gnl|CDD|369129	pfam06904, Extensin-like_C, Extensin-like protein C-terminus. This family represents the C-terminus (approx. 120 residues) of a number of bacterial extensin-like proteins. Extensins are cell wall glycoproteins normally associated with plants, where they strengthen the cell wall in response to mechanical stress. Note that many family members of this family are hypothetical.	2.98097e-84
NZ_CP014870.1|WP_064676087.1|1061097_1061445_-|YbaY-family-lipoprotein	gnl|CDD|378225	pfam09619, YscW, Type III secretion system lipoprotein chaperone (YscW). This entry is encoded within type III secretion operons. The protein has been characterized as a chaperone for the outer membrane pore component YscC. YscW is a lipoprotein which is itself localized to the outer membrane and, it is believed, facilitates the oligomerization and localization of YscC.	1.74493e-23
NZ_CP014870.1|WP_010462862.1|1064253_1064463_+|cold-shock-protein	gnl|CDD|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.24865e-28
NZ_CP014870.1|WP_064676079.1|1052547_1053192_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|379522	pfam14246, TetR_C_7, AefR-like transcriptional repressor, C-terminal region. This family comprises the C-terminal domain of transcriptional regulators of the TetR family. It includes the AefR transcriptional regulator from P. syringae. It is found in association with pfam00440.	7.61481e-32
NZ_CP014870.1|WP_064676081.1|1054391_1057463_+|efflux-RND-transporter-permease-subunit	gnl|CDD|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP014870.1|WP_064676091.1|1065859_1067011_-|succinyl-diaminopimelate-desuccinylase	gnl|CDD|237265	PRK13009, PRK13009, succinyl-diaminopimelate desuccinylase; Reviewed.	0
NZ_CP014870.1|WP_064676074.1|1048495_1049356_+|DUF72-domain-containing-protein	gnl|CDD|182366	PRK10302, PRK10302, hypothetical protein; Provisional.	2.35683e-77
NZ_CP014870.1|WP_064676080.1|1053285_1054386_+|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl|CDD|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	9.17029e-75
NZ_CP014870.1|WP_191637766.1|1051632_1052412_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|377360	pfam04445, SAM_MT, Putative SAM-dependent methyltransferase. This is a family of putative SAM-dependent methyltransferases.	2.7749e-123
NZ_CP014870.1|WP_064676088.1|1061595_1064088_-|glycerol-3-phosphate-1-O-acyltransferase-PlsB	gnl|CDD|235325	PRK04974, PRK04974, glycerol-3-phosphate 1-O-acyltransferase PlsB.	0
NZ_CP014870.1|WP_064676084.1|1059294_1059693_-|YbaY-family-lipoprotein	gnl|CDD|378225	pfam09619, YscW, Type III secretion system lipoprotein chaperone (YscW). This entry is encoded within type III secretion operons. The protein has been characterized as a chaperone for the outer membrane pore component YscC. YscW is a lipoprotein which is itself localized to the outer membrane and, it is believed, facilitates the oligomerization and localization of YscC.	8.09053e-38
NZ_CP014870.1|WP_064676083.1|1058581_1059271_-|DUF4197-domain-containing-protein	gnl|CDD|379394	pfam13852, DUF4197, Protein of unknown function (DUF4197). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 228 and 249 amino acids in length.	6.39889e-93
NZ_CP014870.1|WP_064676090.1|1065050_1065860_-|methyltransferase-domain-containing-protein	gnl|CDD|236841	PRK11088, rrmA, 23S rRNA methyltransferase A; Provisional.	2.52568e-88
NZ_CP014870.1|WP_064676075.1|1049389_1050211_+|isocitrate-lyase/phosphoenolpyruvate-mutase-family-protein	gnl|CDD|379346	pfam13714, PEP_mutase, Phosphoenolpyruvate phosphomutase. This domain includes the enzyme Phosphoenolpyruvate phosphomutase (EC:5.4.2.9). This protein has been characterized as catalyzing the formation of a carbon-phosphorus bond by converting phosphoenolpyruvate (PEP) to phosphonopyruvate (P-Pyr). This enzyme has a TIM barrel fold.	6.13145e-84
NZ_CP014870.1|WP_064676072.1|1047321_1047996_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	gnl|CDD|274750	TIGR03725, T6A_YeaZ, tRNA threonylcarbamoyl adenosine modification protein YeaZ. This family describes a protein family, YeaZ, now associated with the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family may occur as fusions with ygjD (previously gcp) or the ribosomal protein N-acetyltransferase rimI, and is frequently encoded next to rimI. [Protein synthesis, tRNA and rRNA base modification].	4.43445e-73

Protein sequences

>NZ_CP014870.1|WP_064676081.1|1054391_1057463_+|efflux-RND-transporter-permease-subunit
MGFNLSAWALRNRQIVLFLMLLLAVVGALSYTKLGQSEDPPFTFKAMVIRTLWPGATAQEVSRQVTERIEKKLMETGEYERIVSFSRPGESQVTFIARDSMHSVDIPELWYQVRKKTNDIRHTLPPGVQGPFFNDEFGTTFGNIYALTGDGFDYAVLKDYADRIQIQLQRVKDVGKVDLLGLQDEKIWIELSNVKLATLGLPLAAVQQALEEQNAVSTAGFFETTSERLQLRVSGNFQTVDEIKNFPIRVGDRTFRIADVANVRRGFNDPPAPRMRFMAEDAIGLAVAMKEGGDILVLGKALEVEFARIQKNLPAGMQLRKVSDQPAAVKTGVGEFVQVLVEALAIVLLVSFFSLGVRTGMVVALAIPLVLAMTFACMYYLGIGLHKISLGALVLALGLLVDDAIIAVEMMAIKMEQGFDRIKAASYAWTSTAFPMLTGTLITAAGFLPIATAQSGTGEYTRSIFQVVTIALLASWIAAVVFVPYLGEKLLPDLAKIHAAKHGTGDGQADPYGTPFYQRVRRLVEWCVRWRKTVILLTVVLFIGSIVLFRFVPQQFFPASGRLELMVDLKLAEGASLSNTADEVKRLEALLKDHVGIDNYVAYVGTGSPRFYLPLDQQLPAASFAQFVVLAKTIEDREPLRTWLIETLNEQFPALRSRVTRLENGPPVGYPVQFRVTGEHIDEVRALARKVAAKVRENPHVVNVHLDWEEPSKVVYLNIDQDRARALGVSTANLSRFLQSSLTGSSVSQYREDNELIEILLRGTVHERTELSLLPSLAVPTDNGRSVALSQIATLEYGFEEGIIWHRNRLPNVTVRADIYGKEQPATLVQQIMPTLDPIRAELPDGYLLDVGGTVEDSARGQNSVKAGVPLFIVVVLTLLMLQLRSFSRTVMVFLTAPLGLIGVTLFLMVFRQPFGFVAMLGTIALSGMIMRNSVILVDQIEQDIAAGLKPWQAIIEATVRRFRPIVLTALAAVLAMIPLSRSVFFGPMAVAIMGGLIVATALTLLFLPALYAAWFRVREESV
>NZ_CP014870.1|WP_064676080.1|1053285_1054386_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MFRYALPFALPVSLAFFLSACGHEEAPQVTVRPALVVQPEPSARTMESFPGEVRARFEPELAFRIGGKVSRRLVEEGQRVKADQPLAELDPQDVRLQLEATRAQVAAAEANLNLVRAERDRYKTLMDRQMVSRSQYDNAENLFRSGEARLKQIKAEFNVSTNQASYAVLRAPQDGVVAKRAVEVGQVVAAGQTVFTLATDGEREVSISLPEQGFGRFKVGQPVSVELWTQPDQRFAGRIRELSPAADPKSRTFAARISFTEGKVPAELGQSARVFVQAADVVTLSVPLSALTAENGATYVWVVGANNTLKKTPVRIGAFGEKTVPVLEGLKASDWVVAAGVHVLLEGQQVRPVDRSNRVVNLADKE
>NZ_CP014870.1|WP_064676079.1|1052547_1053192_-|TetR/AcrR-family-transcriptional-regulator
MSNTLSAANGPGRPKDLAKRQAILEAAKILFLSNGYANTSMDAVAAEAGVSKLTVYSHFNDKETLFSAAVVAKCEEQLPTLFFELPDGVAVETVLLNIARGFHQLINSDESVNLHRLMMTLGSQDPKLSQIFFEAGPERVLHGMERLLSKVDQSGALSIDKPRNAAEHFFCLLKGAGNFRLLYGCGEPLTGDVAESHVREVVGLFMRAYRREAV
>NZ_CP014870.1|WP_191637766.1|1051632_1052412_+|class-I-SAM-dependent-methyltransferase
MEQPAACRIHVEASTPAFQPQAEQWAERLGLPMQVADAEFALQVGEQGLQLQQLGADAPGPVRVDFVEGGAAHRRLFGGGTGQMIAKAVGIAQGVRPRVLDATAGLGKDAFVLASLGCEMNLIERQPLIGALLEDGLARGAEDFDVAPIVARMRLLKGNSIEVMRNWEGEPPQVIYLDPMFPHREKTALVKKEMRLFRPLVGDDPDAPALLEAALALASHRVVVKRPRKAPCIAGPKPSHALDGKSSRYDIYPKKALKS
>NZ_CP014870.1|WP_064676077.1|1050915_1051536_-|hypothetical-protein
MSDFQPSITGFISPYGDYSRQNTQALSGVSHLWQDFFARALAEQSGEVLPESLNFPPVDLDSPVEPTVGSDLLAHIVSQRECEVKDNKVSPPEPLFLPIAEFEIELLDAPSPPFPPEEIRAQQQQQDFESSWVRPIVLAAGQPVPPAGPAPQARALHLPIAEFELHLLDKPFPPFSPEERLEQQKDFDFDTGWARPIVLQNLRIAA
>NZ_CP014870.1|WP_064676076.1|1050213_1050912_+|extensin-family-protein
MPVLRVVFVLLLIIGAAAAVSVWRGWITPPPQWNPWAPLDVKAAPNFLTRYKLMRLRDDPQLCDQALGSSGLRVSRQADSSGATCPLINTLRVQGGEVALSSSFLASCRLAVSFALFEHHALQPAAQAVYGQPVTRVEHLGSFACRNVYGRENGRRSQHASANALDIAGFRLADGRSISVLKDWPKDNRDARFLRLVRDGACDMFNGVLSPDYNAAHRDHFHLDVGPWSVCR
>NZ_CP014870.1|WP_064676075.1|1049389_1050211_+|isocitrate-lyase/phosphoenolpyruvate-mutase-family-protein
MNAQTLRAQAFKALHERDGAFVIPNPWDAGSAIMLASLGFEALATTSAGYAFSQGRPDGGLTLDQTLANVQAIVAATPLPVAVDLENGFADDPVECAQSLLRAAAAGAVGGSIEDATGREDGPIYCFDHAVARIEAAVAAARSLPFPFTLTARAENFLHGNPDLDDTIRRLQAFADAGADVLYAPGLRSAEEVLAVVRAVAPKPVNVLMSGGLKLTVEQLSQMGVKRISVGSALALAAYGEFFRAAQEIRQSGTFGFTSRSMPFQQANQLFKG
>NZ_CP014870.1|WP_064676074.1|1048495_1049356_+|DUF72-domain-containing-protein
MVLPYYLGCPSWSENAWRDYLYPQDARPAEFLNLYAQVFNAVEGNTTFYASPSAATVQRWADTMPEHFRFTAKFPGDISHSGDLREQLTAAETFLQLLRPLGDRVSPLWLQLSKSFTPQRLSELAGFIDAMDRPLAVEVRHDEFFAKGDAERRLNRLLRDRGVERICLDSRALFSCTSTAPSVLHAQAKKPRVPPRPAAFTQCPQVRFIGHPQLEANDPFLVPWVEKIALWIEEGRTPYIFLHTADNLLAARLAQRFHAQLMLRLPGLAPLPELYREPAAEQLGLL
>NZ_CP014870.1|WP_064676073.1|1048190_1048496_+|hypothetical-protein
MRIDGLSSQSYPIKRQPRKGRVVEDESVDIDGELEFPSEEQLAARAAKASAQRLSNLPARQQDMVYHRAMSKTVSMALASYLSTAGFVEWDADVLGLDLYV
>NZ_CP014870.1|WP_064676072.1|1047321_1047996_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB
MSTLLALDTATEACSVALLHDGKVTSHYEVIPRLHAQKLLPMIQQLLAEAGTSLQAVDAIAFGRGPGAFTGVRIAIGVVQGLAFALDRPVLPVSNLAVLAQRAYREHGVSQVAAAIDARMDEVYWGCYRETAGEMRLVGNEAVLPPEAAALPADASGEWFGAGTGWGYAERIAVNLTGQDAGMLPHAEDLLTLARFAWERGEAIVADEAQPVYLRDKVATPKAR
>NZ_CP014870.1|WP_064676083.1|1058581_1059271_-|DUF4197-domain-containing-protein
MLRPTFHLAGLCAGLMFCASAFALSLSDLSQKDATGGLKDALTQGAQLAVKQLGTPGGFSNNPEVKIELPGKLGKVASKMKQFGMGAQVDQLETSMNKAAESAVTQAQPILVDAVKKMSVTDAKDILSGGNDSATQYLSKTSREQIRVKFLPIVKQATDQVGLAKQYNSFAGQAATLGVLDAKNANIESYVTEQALNGLFEMIGKQEETLRQNPAAAATSLAKKVFGTL
>NZ_CP014870.1|WP_064676084.1|1059294_1059693_-|YbaY-family-lipoprotein
MKKLSLLAVATLLGACQLIQPAAEPQLNGEVYYLQRIALPPNATLSVSLQDVSLADAPAVVLGEQEGPVEGQVPLPFHLSYDPAQVKPGNRYSVSARIEVNGKLMYTTTEQHVVQLDGSDPQSMKIRVHAVR
>NZ_CP014870.1|WP_064676085.1|1059963_1060311_-|YbaY-family-lipoprotein
MSKTDNIYVHGEVYLKADQIFANTALKVVLVNINSKEVVEKQRISLVRTGNDQAVTFKMHFDPLQIDQNEEYGIYAEINSLSAVTHTARQYYPVDLSNTTPSASVFMDYNPRELV
>NZ_CP014870.1|WP_064676086.1|1060415_1061042_-|hypothetical-protein
MTQHTINALLHFPPDFELPEDCEISIRIQNITNRDAPRLHSKWGSNTLPSKRPINFSVIVDSDLVNIGSRFSIDVKIAHQGTALLLDLEQDFWWAGGDHDTDIHLSPVGYIAVEKFWMPRIGYPEDSKLFVKLTTDDNREVVVSESVSLTKQITPFYLRYDPSVIKPGQLYALTGSFETYSQRQLSLGIKPAKLVLMPETVQAPAFGG
>NZ_CP014870.1|WP_064676087.1|1061097_1061445_-|YbaY-family-lipoprotein
MSNEPVKTIGGTVHYLEKIALLPNSTLYVSLLDVSLADASAKELAHQVTPHAETAGLGFNLVYPMADVLPGHSYAISASIKTDGKLVFITAERHSVELGVDHVKGQKILVSRVNH
>NZ_CP014870.1|WP_064676088.1|1061595_1064088_-|glycerol-3-phosphate-1-O-acyltransferase-PlsB
MTRSPLRRLVFGTLRRLLYLWVRSETINQSSLSLNLDRSRPVFYVLQDPSLTDLAVLDTECGKAGLPRPVLPVSVGYLVEPAAFFYLTPAPDWLGRQDKRGAPPTLTRLVSALSQNAAEDAQIIPVSVFWGQSPDSESSPWKLLFADSWAVTGRLRRLLSIIVLGRKTRVQFSAPIHLRELIDHNKGHERTVRMAQRILRVHFRNLKAAVIGPDISHRRNLVKGLLNQPLVRQAILDEAERENISPEKAKAQALRYGNEIASDYTYTAIRFLEVVLSWFWNKIYDGIKVNNIEGVQQVAQGHEVIYVPCHRSHIDYLLLSYLLFRNGLTPPHIAAGINLNMPLIGGLLRRGGAFFMRRTFKGNPLYTSVFNEYLHTLFTKGFPVEYFVEGGRSRTGRMLQPKTGMLAITLRSFLRSSRMPIVFIPVYIGYERVLEGRTYLGELRGASKKKESIFDIFKVIGALKQRFGQVAVNFGEPIKLTEFLDSEQPDWRQQALGPQFKPAWLNETTHRLGEKVAQHLNEAAAINPVNLVALALLSTSRLALDDRAMARVLDLYLALLRKVPYSPHTTLPEGDGRALIEHVKDMDLLSEQSDALGKILYLDEQNAVLMTYYRNNVLHIFALPSLLASFFQSASRMSRDQILRYTRALYPYLQAELFIRWPLDELDAVIDQWLEAFVEQGLLRFENDVYLRPAPSSRHFVLLTLLSKSIAQTLQRFYMTVSLLLNSGQHSITAEELEDLCTVMAQRLSILHGLNAPEFFDKSLFRHFIQTLLDLDVLKRDEAGKLGYHELLGELAEGAAKRVLPAEIRLSIRQVALHRSEDAADIVERV
>NZ_CP014870.1|WP_010462862.1|1064253_1064463_+|cold-shock-protein
MATRETGNVKWFNDAKGYGFIQREDGVDVFVHYRAIRGEGHRSLAEGQQVEYAVVTGEKGLQAEDVVGL
>NZ_CP014870.1|WP_064676089.1|1064598_1064976_-|hypothetical-protein
MRQPDIEIYLKDADVDYKAIAAWLGAALGPCTDWVQKGQTYKCKAGNVPVTWLPKAVGKWNSLFLESDQTPWEDDIACARAAFVALNVEVRCAPGTWVEEEGEETADRWMRISADGEEEITWKTA
>NZ_CP014870.1|WP_064676090.1|1065050_1065860_-|methyltransferase-domain-containing-protein
MLACPICSEPLNAVDNGVACPAGHRFDRARQGYLNLLPVQHKNSRDPGDNLAMVEARRDFLNAGHYAPVARRLAELAAGYAPQRWLDIGCGEGYYTAQIAEALPNADGYALDISREAVKRACKRNPQLTWLIASMARVPLASGSCQFLASVFSPLDWAEAKRLLSSGGGLMKVGPTSGHLMELRERLYDEVREYTDDKHLALVPEGMTLQHSETLEFKLTLEKGQDRANLLAMTPHGWRASAERRAAVIEQVAPFEVTVSMRYDYFVLQ
>NZ_CP014870.1|WP_064676091.1|1065859_1067011_-|succinyl-diaminopimelate-desuccinylase
MTAHADLSPTLQLAIDLIRRPSVTPVDADCQKQMMQRLGDAGFALEPMRIEDVDNFWATHGKHDGPVLCFAGHTDVVPTGPVTAWQIDPFNALIDEHGMLCGRGAADMKGSLAAMTVAAERFVADYPDHKGKVAFLITSDEEGPAHHGTKAVVERLAARKERLDWCIVGEPSSTTLVGDVVKNGRRGSLGAKLTVRGIQGHVAYPHLAKNPIHLAAPALAELAAEHWDHGNDFFPPTSFQISNVNSGTGATNVIPGDLVAVFNFRFSTESTVEGLQKRVAYILDKHGLDWHIDWALSGLPFLTEPGALLDAVASSIKDVTGRETKASTSGGTSDGRFIATMGTQVVELGPVNATIHQVNERVLAADLDVLTDIYYQTLIKLLA

Crispr_ID: NZ_CP014870_3

• CRISPR_ID: NZ_CP014870_3
• CRISPR_location: 1737761-1737866
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_3

Consensus_repeat	Method
ACGATGGACGTCAACGATAACGCG	CRISPRCasFinder

spacers of NZ_CP014870_3

>3.1|1737785|58|NZ_CP014870|CRISPRCasFinder
TCCTTTCAGGGTGCACGCGCTGTCCTTGCGTTTTTCGCGAGCGAGCTCGCTCCTACAT

CRISPR arrays and Neighbor proteins around NZ_CP014870_3

CRISPR arrays

The CRISPR arrays of NZ_CP014870_3

>merge|NZ_CP014870|3|1737761-1737866|CRISPRCasFinder
ACGATGGACGTCAACGATAACGCGTCCTTTCAGGGTGCACGCGCTGTCCTTGCGTTTTTCGCGAGCGAGCTCGCTCCTACATACGATGGACGTCAACGGTAACGCG

>NZ_CP014870|3|3|1737761-1737866|CRISPRCasFinder
ACGATGGACGTCAACGATAACGCG	TCCTTTCAGGGTGCACGCGCTGTCCTTGCGTTTTTCGCGAGCGAGCTCGCTCCTACAT
ACGATGGACGTCAACGGTAACGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_082930271.1|1745998_1747171_-|class-C-beta-lactamase	unknown	unknown	gnl|CDD|236894
NZ_CP014870.1|WP_064676645.1|1739958_1740507_+|DUF4174-domain-containing-protein	unknown	unknown	gnl|CDD|379363
NZ_CP014870.1|WP_064676640.1|1735799_1736621_-|aldo/keto-reductase	unknown	unknown	gnl|CDD|381364
NZ_CP014870.1|WP_064676643.1|1738843_1739212_-|VOC-family-protein	unknown	unknown	gnl|CDD|319939
NZ_CP014870.1|WP_064676633.1|1727550_1728084_+|acireductone-dioxygenase	unknown	unknown	gnl|CDD|224704
NZ_CP014870.1|WP_064676636.1|1730939_1731458_+|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|293786
NZ_CP014870.1|WP_064676650.1|1743598_1745032_-|D-aminoacylase	unknown	unknown	gnl|CDD|226179
NZ_CP014870.1|WP_064676635.1|1729007_1730843_+|long-chain-acyl-CoA-synthetase	unknown	unknown	gnl|CDD|236217
NZ_CP014870.1|WP_064676647.1|1741269_1742637_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|226459
NZ_CP014870.1|WP_064676634.1|1728382_1728661_-|DUF3509-domain-containing-protein	unknown	unknown	gnl|CDD|338217
NZ_CP014870.1|WP_064676641.1|1736935_1737685_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676637.1|1731507_1732848_-|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|270371
NZ_CP014870.1|WP_064676642.1|1738038_1738824_+|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl|CDD|376667
NZ_CP014870.1|WP_064676639.1|1735319_1735769_-|DUF1810-domain-containing-protein	unknown	unknown	gnl|CDD|378062
NZ_CP014870.1|WP_064676644.1|1739259_1739727_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP014870.1|WP_064676646.1|1740641_1741277_-|hypothetical-protein	unknown	unknown	gnl|CDD|131694
NZ_CP014870.1|WP_162493644.1|1732973_1735334_+|DNA-polymerase-II	unknown	unknown	gnl|CDD|235595
NZ_CP014870.1|WP_064676649.1|1743155_1743515_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676651.1|1745057_1745831_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270421
NZ_CP014870.1|WP_064676632.1|1726373_1727519_+|MFS-transporter	unknown	unknown	gnl|CDD|372338

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_082930271.1|1745998_1747171_-|class-C-beta-lactamase	gnl|CDD|236894	PRK11289, ampC, beta-lactamase/D-alanine carboxypeptidase; Provisional.	0
NZ_CP014870.1|WP_064676645.1|1739958_1740507_+|DUF4174-domain-containing-protein	gnl|CDD|379363	pfam13778, DUF4174, Domain of unknown function (DUF4174). This domain of unknown function is found in a putative tumor suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.	2.49216e-26
NZ_CP014870.1|WP_064676640.1|1735799_1736621_-|aldo/keto-reductase	gnl|CDD|381364	cd19138, AKR_YeaE, Escherichia coli YeaE and similar proteins. Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.	1.19431e-159
NZ_CP014870.1|WP_064676643.1|1738843_1739212_-|VOC-family-protein	gnl|CDD|319939	cd08351, ChaP_like, ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins. ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	6.23633e-63
NZ_CP014870.1|WP_064676633.1|1727550_1728084_+|acireductone-dioxygenase	gnl|CDD|224704	COG1791, COG1791, Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown].	6.2704e-57
NZ_CP014870.1|WP_064676639.1|1735319_1735769_-|DUF1810-domain-containing-protein	gnl|CDD|378062	pfam08837, DUF1810, Protein of unknown function (DUF1810). This is a family of uncharacterized proteins. The structure of one of the members in this family has been solved and it adopts a mainly alpha helical structure.	6.20222e-74
NZ_CP014870.1|WP_064676635.1|1729007_1730843_+|long-chain-acyl-CoA-synthetase	gnl|CDD|236217	PRK08279, PRK08279, long-chain-acyl-CoA synthetase; Validated.	0
NZ_CP014870.1|WP_064676647.1|1741269_1742637_-|AAA-family-ATPase	gnl|CDD|226459	COG3950, COG3950, Predicted ATP-binding protein involved in virulence [General function prediction only].	5.72415e-45
NZ_CP014870.1|WP_064676634.1|1728382_1728661_-|DUF3509-domain-containing-protein	gnl|CDD|338217	pfam12021, DUF3509, Protein of unknown function (DUF3509). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 92 to 110 amino acids in length. This protein has two completely conserved residues (G and R) that may be functionally important.	2.4788e-25
NZ_CP014870.1|WP_064676650.1|1743598_1745032_-|D-aminoacylase	gnl|CDD|226179	COG3653, COG3653, N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism].	1.64402e-134
NZ_CP014870.1|WP_064676637.1|1731507_1732848_-|substrate-binding-domain-containing-protein	gnl|CDD|270371	cd13653, PBP2_phosphate_like_1, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.27232e-65
NZ_CP014870.1|WP_064676642.1|1738038_1738824_+|sulfite-exporter-TauE/SafE-family-protein	gnl|CDD|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.05748e-32
NZ_CP014870.1|WP_064676636.1|1730939_1731458_+|ankyrin-repeat-domain-containing-protein	gnl|CDD|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	2.58877e-25
NZ_CP014870.1|WP_064676644.1|1739259_1739727_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.61009e-11
NZ_CP014870.1|WP_064676646.1|1740641_1741277_-|hypothetical-protein	gnl|CDD|131694	TIGR02646, Hypothetical_protein_SMc04429, TIGR02646 family protein. Members of this uncharacterized protein family are found exclusively in bacteria. Neighboring genes in various genomes are also uncharacterized or may annotated as similar to restriction system proteins. [Hypothetical proteins, Conserved].	3.70235e-10
NZ_CP014870.1|WP_162493644.1|1732973_1735334_+|DNA-polymerase-II	gnl|CDD|235595	PRK05762, PRK05762, DNA polymerase II; Reviewed.	0
NZ_CP014870.1|WP_064676651.1|1745057_1745831_-|ABC-transporter-substrate-binding-protein	gnl|CDD|270421	cd13703, PBP2_HisJ_LAO, Substrate binding domain of ABC-type histidine- and lysine/arginine/ornithine transporters; the type 2 periplasmic-binding protein fold. This subgroup includes the periplasmic-binding proteins, HisJ and LAO, that serve as initial receptors in the ABC transport of histidine and lysine-arginine-ornithine amino acids. They are belong to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.84769e-127
NZ_CP014870.1|WP_064676632.1|1726373_1727519_+|MFS-transporter	gnl|CDD|372338	pfam12832, MFS_1_like, MFS_1 like family. This family contains proteins related to the MFS superfamily.	1.83712e-106

Protein sequences

>NZ_CP014870.1|WP_064676641.1|1736935_1737685_+|hypothetical-protein
MVRVLPLITMHTRRYSLLLACLSTLCFTGCTQQQGGDIIDQFRQGKPQEFLQTSVDRMATLAMRDNLDSLYLLMSKLYLRNPEELKKSGFLDARTAGQQVRMAIEMQQPLPTLGGKKDLAALSFAMSPEFLGDRVGAFIYAIGSMLVTAHGNRLEFYMTDAINPTFVNNAARNIEKATWILSQRQTKQGEPLLFSNEISEEGSNLSFAVEFGKIVARLDLLTQMLDERYRRIGLNYAQSLLFLNFLPVQ
>NZ_CP014870.1|WP_064676640.1|1735799_1736621_-|aldo/keto-reductase
MRTLDLAGINVPVIGQGTWRMGEDPSRRSQEVAALRQGIELGMTLIDTAEMYGEGGAEQVVGEAIAGRRDQVFLVSKVYPHNASRDGIPQACERSLQRLGTDYIDVYLLHWRGQYPLEETVAAFERLREAGKIGRWGVSNFDLDDLHELSAPACATNQVLYNLEERGIEFDLLPWCQQHRLPVMAYCPIGQGGEMLAHPALMHVAARHDATPAQVALAWILRQDGVIAIPKAVSPEHVQLNAQAARLQLEAGDLEALDHAFHAPQRKQRLAMV
>NZ_CP014870.1|WP_064676639.1|1735319_1735769_-|DUF1810-domain-containing-protein
MRSTDPLDRFDLKRFIQAQDPVFDQVQDELSDGHKRSHWMWFIFPQFTGLGDSEKSRHFAIRSTAEAVAFLEHPVLSTRLRTCTQLVLDIKQRPIAAIFGHPDELKFHSSMTLFAQVDAEDSLFSQALDQYFHGIPDAWTLTLMDSKQA
>NZ_CP014870.1|WP_162493644.1|1732973_1735334_+|DNA-polymerase-II
MDLQRGFVLTRHWRDTPAGTEVEFWLATDTGPQRIRLPWQPSVAFIPQAQREQAEALLQGEKNLELRPLALQDFEHRPVLGLYCQQHGQLMRLETALRKAGVDMFEADVRPPERYMMERFITAPVVFGGTPGAEGLLLDAQMKPDPDYRPTLRLVSLDIETTARGELYSIALEGCGERQVYMLGPPNGDPGEVDFQLEYCDSRTLLLKKLNEWFARHDPDAIIGWNVVQFDLRVLHEHARRLAVPLKLGRGGEEMQWREHGSRNHYFASAAGRLIIDGIESLRSATWSFPSFSLENVAQTLLGEGKAIDNPYQRMDEINRMFAEDKPALARYNLKDCELVTRIFAKTELLTFLLERASVTGLPADRSGGSVAAFTHLYMPLMHRQGFVAPNLGSKPAQASPGGFVMDSQPGLYESVLVLDYKSLYPSIIRTFLIDPVGLIEGLKHPADSESVPGFRGARFSRNRHCLPAIVARVAEGRETAKREHNAPLSQALKIIMNAFYGVLGSSGCRFFDTRLASSITLRGHEIMLRTRQLIEAQGHTVIYGDTDSTFVWLRRAHGQQEAAQIGHALVDHVNQWWREHVRQEYGLESALELQFETHYKRFLMPTIRGAEEGSKKRYAGLVTRADGSDEMVYKGLETVRTDWSPLARQFQQELYLRIFNRRPYQDYVRDYVRKTLAGEFDDRLIYRKRLRRTLDDYQRNVPPHVRAARIADDYNDRQGRPRQYQNGGWISYVITVAGPEPLEIRSAPIDYDHYVSRQLQPVADAILPFVDDDFSTLIGGQLGLF
>NZ_CP014870.1|WP_064676637.1|1731507_1732848_-|substrate-binding-domain-containing-protein
MTLRVLFLWVLCASLPLAVSAGDLPTPEQGPVLRIQGSNTIGAALGPALVEGLMREQGLLKVHREARDTANELRVVGETVQGRRVVVDIAAHGSSTGFTALRTATTDLAASSRPIKDSERRVLQSLGDLKQPGAEQVIAIDGLAIILHPQNPLNQLDTEQLAQIFSGEASTWEAVGGRGGPIHLYARDDHSGTHDTFNELVLAGRGKTLSRTAKRFESSEQLSDAVSLDPQGIGVIGLPYVRQAKAVAIADGQSQAMLPLDRLIATEDYPLSRRLFFYLPPTGNNPWAHALVAFAQGRQGQAIVAANGFVAQTVQAMAVTPNALMPEGYQALSRHAQRLSVNFRFEEGSATLDNKARQDLSRVLDYIRQQDKTHRQVTLVGFGDAKSDPARADLLSKLRAMAVRRELVKSGVVLREVRGFGAEMPVAANSADEGRIRNRRVEVWVY
>NZ_CP014870.1|WP_064676636.1|1730939_1731458_+|ankyrin-repeat-domain-containing-protein
MSDQSRQMTPEEAAEFAEQVFNKAREGDAAMMAALLTKGLPPNLRNHKGDTLLMLAAYHGHVETVKVLLEHKADPEIRNDNGQSPIAGAAFKGDLATVTALVEGGAQVEGSSFDGRTALMMAAMFNRVEIVDYLIGKGADPKAKDANGVTALDAAKTMGAVDTTAQLEKLLG
>NZ_CP014870.1|WP_064676635.1|1729007_1730843_+|long-chain-acyl-CoA-synthetase
MSTPHDTITWGMMLRKLPSIAKAIPRVVKGMKAANVKDPTQACGLGWSFEQATLRNPDGPALLQGEVALTYAQVNQWANRIAHHLIAQGIRKGDGVAVFIENRPELLVTILAVAKVGAISALLNTSQTRDTLVHSLNLVAPAAIIVGEELVPAFSAVRERVSITPARTWFVADQGTYTHPGIAPDGFINLMAASVDACSDNPASSQQVFFDDPCFYIYTSGTTGLPKAGVFKHGRWMRSSASFGMIALDMRPEDVVYCTLPLYHATGLCVCWGSAISGASGFAIRRKFSASQFWNDVRQYRATTLGYVGELCRYLVDQPPAVDDNQHSVTKMIGNGLRPGAWREFKTRFGVRHICELYAASDGNIGFTNVLNFDNTVGFSLMSWELAAYDHDTGLPTRNAKGFMRKVAKGEQGLLLAKIDDKAPLDGYTDPQKTAKVVLQDVFEKGDRYFNTGDLMRNIGFGHAQFVDRLGDTYRWKGENVSTTEVENILLQHPNICEAVAYGVEIRNTNGRAGMAAITPAESLATLDFSELLAFAREQMPAYAVPLFLRVKVKMETTGTFKYQKTRLKDEAFDPGRTGDDPIYAWLPGTGTYVQVTEQLLGEIHDGKYRY
>NZ_CP014870.1|WP_064676634.1|1728382_1728661_-|DUF3509-domain-containing-protein
MSLIQEKFSSLFSNFEVTTQPRPDGGILLTLRSTEGKVFKRSISYQQLHAGDQLSWVISAIRRDLAEQASELPQISMLQSQQRFALPTYHSA
>NZ_CP014870.1|WP_064676633.1|1727550_1728084_+|acireductone-dioxygenase
MSSLSVYPVSSPELPNKVLTHFDDIASTLAEQGVRFDRWQAATKLQPGASPEDIIGAYQAPIDALMTEQGYINVDVVSQTSDHPQTAELLKEYRGDEDVVRFFVAGRGLFSLHIGDYVYAVLCEKNDLISIPAGTPHWFDMGEHPHFVAICLFNQAEGGKTDFTGENIASRFARLED
>NZ_CP014870.1|WP_064676632.1|1726373_1727519_+|MFS-transporter
MAALPYWRLSSFYLFYFALLGSTAPFLALYFDHLGFSSARIGELVAIPMLMRCVAPNIWGWLGDYTGQRLAIVRFGAVCTLLTFSLIFVSKSYAWLAMVMALHAFFWHAVLPQFEVITLAHLKGQTSRYSQIRLWGSIGFIITVVALGRLFEWLSLDIYPVALLLILAGIVVSSLWVPNAQPLQGERLAGDGFLQQLRSPGVLAFYACVALMQLSHGPYYTFLTLHLERLGYSRGLIGMLWAVGVVAEVLMFLAMSKILARFSVRRVLLASFLLAALRWLLLGSFAEYLWVLLFAQVLHAATFGSFHAAAIQFVQRSFGARQQGQGQALYAALAGTGGALGALYAGYSWNALGATLTFSIASLAAFAAAVMIATCMQEDRP
>NZ_CP014870.1|WP_064676642.1|1738038_1738824_+|sulfite-exporter-TauE/SafE-family-protein
MEFVNFGLVVAGLVVGFIVGMTGVGGGSLMTPILLWFGVNPATAVGTDLLYAAITKSSGVLVHKKNNNIDWSITGWLTLGSVPAVLMTLWFLSTLQTSPDAMNAVIKQALGFVLFATALAIFFKKRLLDFAHKRAGGNYNPSGPRLNGLTVLTGLVLGTMVALTSIGAGALGTVALFILYPMLPTRRLVGTEIAHAVPLTLVAGLGHASMGNMDWHVLGYLLVGSLPGIYLGSHLTGRISDEMLRPCLATMLALIGYKLAF
>NZ_CP014870.1|WP_064676643.1|1738843_1739212_-|VOC-family-protein
MSAQLNHTIVWCRDKQTSANYLTDILGLPGPEPFGPMLVVKLDNGVSLDFYNNDPPIASQHYAFLLGDDEFDAAFARLQARKQPWWADPGKQRLDEINDYGGGRRVYFDDPDGHLLEIFTRE
>NZ_CP014870.1|WP_064676644.1|1739259_1739727_-|GNAT-family-N-acetyltransferase
MEIDYLCNHPALIPELAELNFKEWGQFKPGDTLQARTERMRAACGKGAVPTVLVALDGTQLLGGALLIESDLESRPELTPWLAGVYVKAEHRGRGIASGLVSRIVEEAAALSIPRLFLYTDSAQSLYARLGWEIVEQLDDDGLEVTVMARDTSKV
>NZ_CP014870.1|WP_064676645.1|1739958_1740507_+|DUF4174-domain-containing-protein
MLIRSLTLATLLAFAGTLFAADGDSPLDMDKGRARPLIVIAPSTVDPTWVSLKKALDDPANRKGFDDRNMVLYSVLNLMGQREGKDLGPQDTAALIRSLKLGAGPKTKVILVGKDGEKKLEQSDAVDLQAIFKTIDELPATEKEATAPTPPPVTEPVPAKGAKATKPAKPTKPAKPPEMPDD
>NZ_CP014870.1|WP_064676646.1|1740641_1741277_-|hypothetical-protein
MRKIDKGMEPQSLTRWKRSNNALRYRDLPREESRSIRSSCISEQYGLCAYCCQSITIDEAHNEHLESQDRAPNRTLDFFNIVASCQRPNQCGHGRGTRLLPLTPLMAECETELKFYLSGLVTGCTERARVSIEALNLGHTEESNRGLVGARKQLVDALIYSHSVHPEDLQFEDELLLGLLLEDLKTPDAAQCLQPFSPVLVNVISNFLAQP
>NZ_CP014870.1|WP_064676647.1|1741269_1742637_-|AAA-family-ATPase
MEINRFKVTDVGRFTELDIQLAPTAKHPSNVTVLVGNNGAGKTTLLKSLATSLSWLVARIRTEKGNGNYLAEEDIRNGASSALILIGVVDESHARSSRSDANPEDALFTWGIARGRQGRKAHIHSSLGDVSLLADHYRNELTADDKASLPLIAYYPVERSVLEIPLKIRTKHTFDQLDGYDNSLNRGVDFRRFFEWFREREDSENETGVSDTALAEISEKFGNDSDIWKTLFQLKASSRDRQLTAVRSAIAAFMPGFSNLRVQRKPRLHMAIDKDGVTLNVSQLSQGEKSMMALVGDIARRLAMMNQPLDNPLMGDGIVLIDEVDLHLHPKWQRSLIRQLTETFPNCQFVLTTHSPLVISDAKDVLVYVLDDGELQERNGLYGLDANQVLLEVMDTDIRNSDVQQRLNRLLERLQDGDLDAAKKLFSELSLELPEGHLELAKAALLIRKLELRRA
>NZ_CP014870.1|WP_064676649.1|1743155_1743515_+|hypothetical-protein
MKKVSPNPPETSSDSDPLDPVPLSSITEPAISARLRNPNHADPVSHIFTIVPGVDTATLLCHACETLASLNVLVTDLACKLESSNRNVALSIQQLAVVGELLVNRALDNIDPPEGAPAV
>NZ_CP014870.1|WP_064676650.1|1743598_1745032_-|D-aminoacylase
MTVIDTLIRNATLIDGTGAPPFVGDVAVVDGRIHGIGSFPEQDARNVIDARGKILSPGFIDVHTHDDLALLKQPAMLPKISQGVTTVIVGNCGISAAGVRLRGEPPDPMNLLGEAADFKYPSFSAYVAAIEAVRPAVNVAALVGHTALRANHMQQFDRPATTHELEAMREDLKAALEQGALGLSTGLAYRNALQAPTTEVDFLAAILQDVGGIYVSHIRSEDDEIIEAIDEAIDIGRHAGVPVIISHLKCAGRGNWGRSEAIIGRIDNARQQHPVGCDCYPYAASSTTIDPRIVDEGFRIQITWSTPHPEMAGKNLKDIAALWNLSQVDAARRLEPGGAIYHEMDEADVSRILAYPHTMIGSDGLPNDPRPHPRLWGTFPRVLGHYSRDQGLFPLEEAVRKMTGLPAERFGLRDRGRLEVGACADLVLFDAGDIRDRATFDQPTLPPQGIEAVWVNGVLSYIQGQSTEARSGQFIRR
>NZ_CP014870.1|WP_064676651.1|1745057_1745831_-|ABC-transporter-substrate-binding-protein
MKKTLCLGLALAVCVTSALAEDKPLRIGIEAAYPPFAFKTSDGSIGGFDYDIGNALCAQMQTKCVWVEQEFDGLIPSLKVRKIDAVISSMLITEERKRSVMFTDKYYASPARLVMKAGTSVDDDFNQLKGKRIGVQRGTSQDRYATDKLQPLGTEIVRYGSQSEIYLDMQSDRLDGTIANAAPLQEGFLKTPQGQGFAFVGPELRNKEYFGEGTGIAVSKGNTELAQRFNTAIKALRADGTYQQVEKKYFDYNIYGD
>NZ_CP014870.1|WP_082930271.1|1745998_1747171_-|class-C-beta-lactamase
MESGSVMPEYNLKKFASYSAFVLFLGAGHCAADDNIESIVNTAIEPVMQQHQIPGVAVAITVNGQAHYFNYGVASKENGNAVTENTLFEIGSVSKTFTATLAAYAQATGKLSLSDKASNVLPALRGSAFDDISVLQLGTYSAGGLPLQFPDEADSPDKMLGYFKQWKPTYTAGSHRQYSNPSLGLFGYLAAESMGAPFDEVMEKTLLPKLGLKHTFLKVPQDQMGLYAQGYDKGNKPVRVGPGALDSEAYGVKTSAADLLRYVQVNMNPAGLEAPLQRAIATTHTGYYKVGDMTQGLGWELYGYPVTLDQLLDGNSTQMTMDAHEVQLLNPLQPLPDVVLVNKTGSTGGFGAYVAYVPSKDIGIVILANKNYPNAERVKVAHTVLSALSQ

Crispr_ID: NZ_CP014870_4

• CRISPR_ID: NZ_CP014870_4
• CRISPR_location: 1883975-1884602
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 9 spacers

Consensus repeat of NZ_CP014870_4

Consensus_repeat	Method
GAAGGCGGCCTCGAGCCTTGCACCGCCCAT	CRT

spacers of NZ_CP014870_4

>4.1|1884005|36|NZ_CP014870|CRT
GAAGACGCTTTCGCCGGCAAGCCTGGCTCCTACGGT
>4.2|1884071|36|NZ_CP014870|CRT
GAAGACGCTTTCGCCGGCAAGCCTGGCTCCTACGGT
>4.3|1884137|37|NZ_CP014870|CRT
GAAGACGCCTTCGCCTGTAGGAGCGAGGCTTGCCCGC
>4.4|1884204|36|NZ_CP014870|CRT
AAAGACGCCTTCGCCGGCAAGCCTGGCTCCTACGGT
>4.5|1884270|37|NZ_CP014870|CRT
GACGACGCCCTCGGCTGTAGGAGCGAGGCTTGCCCGC
>4.6|1884337|37|NZ_CP014870|CRT
AAAGACGCTTTCGCCTGTAGGAGCGAGGCTTGCCCGC
>4.7|1884404|36|NZ_CP014870|CRT
AAAGACGCTTTCGCCGGCAAGCCTGGCTCCTACGGT
>4.8|1884470|37|NZ_CP014870|CRT
GAAAACGCCTTCGCCTGTAGGAGCGAGGCTTGCCCGC
>4.9|1884537|36|NZ_CP014870|CRT
AAAGACGCTTTCGCCGGCAAGCCTGGCTCCTACGGT

CRISPR arrays and Neighbor proteins around NZ_CP014870_4

CRISPR arrays

The CRISPR arrays of NZ_CP014870_4

>merge|NZ_CP014870|4|1883975-1884602|CRT
GAAGGCGGCCTCGAGCCTTGTACCGCCCATGAAGACGCTTTCGCCGGCAAGCCTGGCTCCTACGGTGAAGGCGGCCTCAAGCCTTGCACCGCCCATGAAGACGCTTTCGCCGGCAAGCCTGGCTCCTACGGTGAAGGCGGCCTCGAGCCTTGCACCGCCCATGAAGACGCCTTCGCCTGTAGGAGCGAGGCTTGCCCGCGAAGGCGGCCTCAAGCCTTGCACCGCCCATAAAGACGCCTTCGCCGGCAAGCCTGGCTCCTACGGTGAAGGCGGCCTCGAGCCTTGCTGCGCCCATGACGACGCCCTCGGCTGTAGGAGCGAGGCTTGCCCGCGAAGGCGGCCTCGAGCCTTGCACCGCCCATAAAGACGCTTTCGCCTGTAGGAGCGAGGCTTGCCCGCGAAGGCGGCCTCGAGCCTTGCACCGCCCATAAAGACGCTTTCGCCGGCAAGCCTGGCTCCTACGGTGAAGGCGGCCTCGAGCCTTGCACCGTCCCTGAAAACGCCTTCGCCTGTAGGAGCGAGGCTTGCCCGCGAAGGCGGCCTCAAGCCTTGCACCGCCCATAAAGACGCTTTCGCCGGCAAGCCTGGCTCCTACGGTGAAGGCGGCCTCGAGCCTTGCACCGCCCAT

>NZ_CP014870|4|1|1883975-1884602|CRT
GAAGGCGGCCTCGAGCCTTGTACCGCCCAT	GAAGACGCTTTCGCCGGCAAGCCTGGCTCCTACGGT
GAAGGCGGCCTCAAGCCTTGCACCGCCCAT	GAAGACGCTTTCGCCGGCAAGCCTGGCTCCTACGGT
GAAGGCGGCCTCGAGCCTTGCACCGCCCAT	GAAGACGCCTTCGCCTGTAGGAGCGAGGCTTGCCCGC
GAAGGCGGCCTCAAGCCTTGCACCGCCCAT	AAAGACGCCTTCGCCGGCAAGCCTGGCTCCTACGGT
GAAGGCGGCCTCGAGCCTTGCTGCGCCCAT	GACGACGCCCTCGGCTGTAGGAGCGAGGCTTGCCCGC
GAAGGCGGCCTCGAGCCTTGCACCGCCCAT	AAAGACGCTTTCGCCTGTAGGAGCGAGGCTTGCCCGC
GAAGGCGGCCTCGAGCCTTGCACCGCCCAT	AAAGACGCTTTCGCCGGCAAGCCTGGCTCCTACGGT
GAAGGCGGCCTCGAGCCTTGCACCGTCCCT	GAAAACGCCTTCGCCTGTAGGAGCGAGGCTTGCCCGC
GAAGGCGGCCTCAAGCCTTGCACCGCCCAT	AAAGACGCTTTCGCCGGCAAGCCTGGCTCCTACGGT
GAAGGCGGCCTCGAGCCTTGCACCGCCCAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064676739.1|1871607_1873842_-|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl|CDD|183173
NZ_CP014870.1|WP_064676755.1|1894720_1895161_-|universal-stress-protein	unknown	unknown	gnl|CDD|366180
NZ_CP014870.1|WP_064676743.1|1876449_1876839_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676750.1|1886452_1887595_+|4-phosphoerythronate-dehydrogenase-PdxB	unknown	unknown	gnl|CDD|166874
NZ_CP014870.1|WP_064676741.1|1874519_1875308_-|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
NZ_CP014870.1|WP_064676747.1|1882262_1883336_+|23S-rRNA-(cytidine(2498)-2'-O)-methyltransferase-RlmM	unknown	unknown	gnl|CDD|236971
NZ_CP014870.1|WP_064676751.1|1887772_1887952_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676757.1|1896434_1898582_+|fatty-acid-oxidation-complex-subunit-alpha-FadB	unknown	unknown	gnl|CDD|183293
NZ_CP014870.1|WP_064676754.1|1892520_1894437_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|236861
NZ_CP014870.1|WP_064676740.1|1873866_1874301_-|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl|CDD|319971
NZ_CP014870.1|WP_064676744.1|1877026_1877926_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_193408122.1|1884658_1886110_-|MATE-family-efflux-transporter	unknown	unknown	gnl|CDD|234981
NZ_CP014870.1|WP_064676742.1|1875958_1876330_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676745.1|1878221_1879109_+|mechanosensitive-ion-channel-family-protein	unknown	unknown	gnl|CDD|223740
NZ_CP014870.1|WP_064676758.1|1898612_1899788_+|acetyl-CoA-C-acyltransferase-FadA	unknown	unknown	gnl|CDD|181592
NZ_CP014870.1|WP_064676756.1|1895366_1895804_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676746.1|1879298_1882040_-|aconitate-hydratase-AcnA	unknown	unknown	gnl|CDD|236445
NZ_CP014870.1|WP_064676748.1|1883646_1883898_+|sulfurtransferase-TusA	unknown	unknown	gnl|CDD|178967
NZ_CP014870.1|WP_064676753.1|1890378_1892307_-|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl|CDD|183236
NZ_CP014870.1|WP_064676752.1|1888215_1889994_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|131259

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064676739.1|1871607_1873842_-|polysaccharide-biosynthesis-tyrosine-autokinase	gnl|CDD|183173	PRK11519, PRK11519, tyrosine-protein kinase Wzc.	0
NZ_CP014870.1|WP_064676755.1|1894720_1895161_-|universal-stress-protein	gnl|CDD|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	7.81821e-34
NZ_CP014870.1|WP_064676750.1|1886452_1887595_+|4-phosphoerythronate-dehydrogenase-PdxB	gnl|CDD|166874	PRK00257, PRK00257, 4-phosphoerythronate dehydrogenase PdxB.	0
NZ_CP014870.1|WP_064676741.1|1874519_1875308_-|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	6.41074e-11
NZ_CP014870.1|WP_064676747.1|1882262_1883336_+|23S-rRNA-(cytidine(2498)-2'-O)-methyltransferase-RlmM	gnl|CDD|236971	PRK11760, PRK11760, putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional.	0
NZ_CP014870.1|WP_064676757.1|1896434_1898582_+|fatty-acid-oxidation-complex-subunit-alpha-FadB	gnl|CDD|183293	PRK11730, fadB, fatty acid oxidation complex subunit alpha FadB.	0
NZ_CP014870.1|WP_064676754.1|1892520_1894437_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|236861	PRK11147, PRK11147, ABC transporter ATPase component; Reviewed.	0
NZ_CP014870.1|WP_064676740.1|1873866_1874301_-|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl|CDD|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	1.37934e-60
NZ_CP014870.1|WP_193408122.1|1884658_1886110_-|MATE-family-efflux-transporter	gnl|CDD|234981	PRK01766, PRK01766, multidrug efflux protein; Reviewed.	0
NZ_CP014870.1|WP_064676745.1|1878221_1879109_+|mechanosensitive-ion-channel-family-protein	gnl|CDD|223740	COG0668, MscS, Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane].	2.43251e-36
NZ_CP014870.1|WP_064676758.1|1898612_1899788_+|acetyl-CoA-C-acyltransferase-FadA	gnl|CDD|181592	PRK08947, fadA, 3-ketoacyl-CoA thiolase; Reviewed.	0
NZ_CP014870.1|WP_064676746.1|1879298_1882040_-|aconitate-hydratase-AcnA	gnl|CDD|236445	PRK09277, PRK09277, aconitate hydratase AcnA.	0
NZ_CP014870.1|WP_064676748.1|1883646_1883898_+|sulfurtransferase-TusA	gnl|CDD|178967	PRK00299, PRK00299, sulfurtransferase TusA.	6.15628e-48
NZ_CP014870.1|WP_064676753.1|1890378_1892307_-|transglycosylase-SLT-domain-containing-protein	gnl|CDD|183236	PRK11619, PRK11619, lytic murein transglycosylase; Provisional.	2.19082e-103
NZ_CP014870.1|WP_064676752.1|1888215_1889994_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|131259	TIGR02204, system_ATPase_and_permease_component, ABC transporter, permease/ATP-binding protein. This protein is related to a Proteobacterial ATP transporter that exports lipid A and to eukaryotic P-glycoproteins.	0

Protein sequences

>NZ_CP014870.1|WP_064676748.1|1883646_1883898_+|sulfurtransferase-TusA
MSEMIETPVDGTLDATGLNCPEPVMMLHQHIRDLVPGGLLKVIATDPSTRRDIPKFCVFLDHELVGQHEAAGTYLYWIRKKSG
>NZ_CP014870.1|WP_064676747.1|1882262_1883336_+|23S-rRNA-(cytidine(2498)-2'-O)-methyltransferase-RlmM
MNTLFMHCRPGFEGEVCSEISEHAARLNVAGYAKAKTASACAEFICTEEDGAERLMRGQRFADLIFPRQWARGIFIDLPETDRISVILAHMADFPLCGSLWLEMVDTNDGKELSNFCKKFEGHLRKALMAAGKLVEDPFKPRLLLTFKSGREVFMGLAESNNSAMWPMGIPRLKFPREAPSRSTLKLEEAWHHFIPRDQWDERLHSDMTGVDLGAAPGGWTWQLVNRGMLVTAIDNGPMAESLMETGLVQHLMADGFTFKPRQPVDWMVCDIVEKPARNAAMLEEWIGEGHCREAVVNLKLPMKQRYAEVKRLLERIADGFKERGIRVEIGCKQLYHDREEVTCHLRRLDVKKPKSR
>NZ_CP014870.1|WP_064676746.1|1879298_1882040_-|aconitate-hydratase-AcnA
MPSLDSLNTLKTLQVDDKTYHYFSLPDAAKSLGDLDQLPMSLKVLLENLLRWEDDKTVTSADLKAIAAWLKERRSDREIQYRPARVLMQDFTGVPAVVDLAAMRAAMAKAGGDPQRINPLSPVDLVIDHSVMVDKFGSASAFEQNVDIEMQRNGERYAFLRWGQSAFDNFSVVPPGTGICHQVNLEYLGRTVWTKDEDGRTYAFPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPVSMLIPEVIGFKLTGKLKEGITATDLVLTVTQMLRKKGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGFFPVDDITLDYLRLSGRPLATVKLVEAYCKAQGLWRLPGKEPIFTDSLALDMGSVEASLAGPKRPQDRVSLPNVPQAFSDFTDLQFKPTSKEEGRLESEGGGGVAVGNADLAGEADYDYEGQTYRLKNGAVVIAAITSCTNTSNPSVMMAAGLVAKKAVEKGLKRKPWVKSSLAPGSKVVTDYYKAAGLTQYLDALGFDLVGYGCTTCIGNSGPLAEPIEKAIQQADLTVASVLSGNRNFEGRVHPLVKTNWLASPPLVVAYALAGTVRMDISSEPLGTDQDGNLVYLRDIWPSTQEIADAVNQVNTAMFHKEYAEVFAGDEQWQAIEVPQAATYVWQDDSTYIQHPPFFDDIGGPPPVVKDVAGARVLALLGDSVTTDHISPAGNIKADSPAGHYLRDKGVEPRDFNSYGSRRGNHEVMMRGTFANIRIRNEMLGGEEGGNTIYIPTGEKIPIYDAAMRYQAAGTPLVVIAGQEYGTGSSRDWAAKGTNLLGVKAVIAESFERIHRSNLVGMGVLPLQFKLDQNRKSLNLTGKETLDILGLTNVELTPRMNLTLVITRPDGSREKVEVLCRIDTLNEVEYFKSGGILHYVLRQLIAS
>NZ_CP014870.1|WP_064676745.1|1878221_1879109_+|mechanosensitive-ion-channel-family-protein
MDELNSVASDSVDKANELVDLLIQYGSAFGLKIIFAVLFWIVGRWMISFIVRFVQRSMTRQKIDPTVLRYVGSFITVTLNIILVIAILGYCGIETTSFAAILAAVGLAIGMAWSGLLANLAAGGFIIVLRPFKVGDEIGAGGVVGTVTEIGLFVTTVNTADNVLTLVGNNKIFSDTIQNFSSNDFRRVELSFSLPFETDERVVVGLLQQRLGKVANVLSAPAVDVRLVGVNSESVVLMVRLCCHSEHYGAVRFDANGVIREVLKNRGDGQVEIDLVSGVVGESQRSLGGVGREVG
>NZ_CP014870.1|WP_064676744.1|1877026_1877926_-|hypothetical-protein
MTLASKNPDQHARIAIDIAQMATSIAVQPPYFAFTSLYTLPDEWDIYGEFTPEQPRGNEQGPLATAEAGRHLAILGSCAAALTQPEGTRVYYLASRAQWDLRYYPTGLGHTPSMTARAKIVEQTRKTVTAKTQLLLRGHLFAELVVSYHVLAEKTFEKLFASYRTPASLPSGQSPYAEALQLSVLERSKQEITACSVGFCAARCEGHFPQYATWPVAVIMYGMSQALSRLLDHKMRRAVSYRLSHVTLDAAELVPAARQLQFHARLSSMDDNGKYCDVVCSAANAGRVIATACAEVAIE
>NZ_CP014870.1|WP_064676743.1|1876449_1876839_+|hypothetical-protein
MPPIREKKNQPTWVEHGLPDLRSLERELRSAAIEEIDAATDHQAAIELMEQHLGFIDPAVISIDVVTPMGLVTIHRGSIYHIVEKRFDARERCFMTAKEKGRFFRTALKNLLDIHMHTLKQGCGGLTLR
>NZ_CP014870.1|WP_064676742.1|1875958_1876330_+|hypothetical-protein
MFKVTPNPPDTDPTSLHQPPDSENHDELVKRALDFYANPAAHAAVIKATPRQLDSMFIVNPQVDVETLLGHACESLASANVMAMDLADHLDGTSRNSLLGIAQVIMLGELAVNRALDRIDASE
>NZ_CP014870.1|WP_064676741.1|1874519_1875308_-|CPBP-family-intramembrane-metalloprotease
MLRLPWPYLTLLTAGYVLALTHGQLSLQAALPLTLLLLAGIAVQPQNHPYARYLGHTLFILLALTLALHYLPGFHNAQVIPPQHLSENAIPFSMYLNLDKPLIGFWLILACPWIIAQRSLNQTLKTSTITLSLTALLTLASACLLGIIEWSPKWPDVARLWLLNNLLLVTLVEEALFRGYIQGGLTQRLKHLPYGEHFALLFAALLFGLAHWGAGWQWVFLATLAGIGYGLAYRFGGLAAAVATHFGLNLLHFGLFTYPMLA
>NZ_CP014870.1|WP_064676740.1|1873866_1874301_-|low-molecular-weight-phosphotyrosine-protein-phosphatase
MFNKILVVCIGNICRSPTVEALLKSRLAHRGIDVSSAGLGALVDKPMDSTALEVLREHGGDLPDHKGRQLTREMLQQADIVLTMEKRHVESIARMAPEVRGKTFLLGKWQKDQEIPDPYRQQKVAFEHVYRLMTQGVDSWSKKL
>NZ_CP014870.1|WP_064676739.1|1871607_1873842_-|polysaccharide-biosynthesis-tyrosine-autokinase
MTSPNSAPIQEHRDDDDNIDLLALLGTLIDSKWIIIGITALFCAIGVAVALLSTPIYQANALVQVEEKKGGMSALGGMGEMGEMFGGTSPAVTEIELLKSRAVLGRAVENLKLDIIIEPNYFPLIGHFLSRRFQPTSLNELAPPSLGLNSYTWGGEKLDIFQLEVPDDYLGTELTLRAEGAGAFTLLNDDDEVLIKGQAGEKLEQDGFKVQIATLNANAGSLFSVTKQRRLNTILQYQEDVSASERGKESGIIGLSLENENPALAKKVLDEINRLYVLQNVQRNSAEAAQSLEFLRTQLPDVRKQLEKAEGQLNAYQTSARSVDITIETKAVLDQIVALETLISELKLKQAEMEHRFTREHPAYQALMTQMGQLDQQKRALEKKVKNLPETQQELLRLARDMQVTTEIYTQLLNKTQELDIVRAGTVGNVRIIDSADANIEKPVKPKKPLIVLIATLLGGLIAVAYVLIRKALNRGIEDPEAIEQLGIPVYASIPLSKGQSLIESNVKGNGRNITGSLLLAVNNPADLAVESLRSLRTSLHFATLEAKNNILMISGPSPAVGKSFVSCNLAAIIAQTGQKVLLVDADMRKGYLNKLFRLDVSNGLSDLLAGKIDLNTATHATEVDNLHVITRGQIPPNPSELLMHSNFTQFLDNVSSQYDVVIIDTPPILAVTDAALVGRQAGTSLIVTRFGVNAAKEILVTKRRFEQNGIVVKGAIFNAVERKASAYGYGNYSYYQYEYASDK
>NZ_CP014870.1|WP_193408122.1|1884658_1886110_-|MATE-family-efflux-transporter
MPRHAHQTPLDVPPLNSVTDRPAAPALTRPARVRLELKTLLALALPIMVAQLATTAMGFVDAVMAGRVGPRDLAAVALGNSIWVPVFLLMTGTLLATTPKVAQRFGAGTHSEIGPIVRQALWLALVVGLIATIMLFSAEPILHLMKVDPELIGPCMQYLHGIASGLPAVAVYHVLRCFSDGLGRTRPAMVLGLCGLALNIPLNYVFIYGHFGVPAMGGVGCGWATAIVMWVMALGMAGWERWAPAYQSSKLFSRFDWPQWSVIKRLLGIGMPIGIAVFAESSIFAVIALLIGSLGATVVAGHQIALNFSSLVFMIPYSLGMAVTVRVGQALGRQQPREARFAAGVGMGTALAYACISASMMLLLREQIATIYTADPTVIQVAAMLIVYSALFQFSDAIQVTAAGALRGYQDTRVTMILTLFAYWGIGLPVGYILGLTDWFGPPSGPSGLWQGLIVGLSCAALMLSIRLTRSARRQIRVGDAYR
>NZ_CP014870.1|WP_064676750.1|1886452_1887595_+|4-phosphoerythronate-dehydrogenase-PdxB
MLIVADENIPLLDAFFEGFGEIRRVPGRSIDRATVEQADVLLVRSVTNVNRALLEGSKVRFVGTCTIGTDHLDLDYFQRAGITWSSAPGCNARGVVDYVLGSLLTLAEIEGADLTQRTYGVVGAGEVGGRLVKVLKGLGWKVLVCDPPRQAAEGGDYVSLEQIIEQCDVISLHTPLKKHGAQSTWHLFDKNRLNQLKPGAWLINASRGPVVDNTALRQVLLQREDLQAVLDVWEGEPEVDVALAELCVLATPHIAGYSLDGKQRGTAQIYQAYCRFLGQPEQVSLSDLLPAPWLSQVTLNGQSDPAWALAMVCRAVYDPRRDDADFRRSLVGNVSEQRAAFDTLRKHYPLRREIDGLQVRVEGDSPVLHKMVAALGAVAV
>NZ_CP014870.1|WP_064676751.1|1887772_1887952_-|hypothetical-protein
MSLQNSSEDKIQVIRTQPDQSLGCSIIDEKGQEVPITEDMVQDACRELEKRLVKPAEEK
>NZ_CP014870.1|WP_064676752.1|1888215_1889994_+|ATP-binding-cassette-domain-containing-protein
MLSARQRRAFRLASRFLAPYRWPAFGALIALVVTAGITLSMGQGIRLLVDQGFMTQSPHLLNQSIGLFLLLVLGLAIGTFTRFYLVSWIGERAVADIRRQVFNHLIYLHPGFYEDNRSSEIQSRLTADTTLLQSVIGSSLSLFLRNLLMVIGGIVLLFVTNPKLTSIVVIALPLVIAPILIFGRRVRSLSRLSQDRIADIGSYVVETLGQIKTVQAYNHQAQDEQRFAVTVEEAFDTARKRIFQRAWLITLVIVLVLGAVGVMLWVGGMDVIAGRITEGELAAFVFYSLIVGSAFGTLSEVIGELQRAAGAAERIAELLRSENIIQPPTTGLVTLPERVKGELVLQDLRFSYPSRPESYAVDGLNLTINAGETLALVGPSGAGKSTVYDLLLRFYDPAEGRILLDGIPLTQLDPLDLRRCFALVSQNPALFYGSIEENIRYGNPTATLAQVKEAATIAYAHDFIEAMPNGYQTHLGDAGLGLSGGQRQRLAIARALLVDAPILLLDEATSALDAQSEHLIQQALPSLMKNRTTLVIAHRLATVKNADRIAVMDQGKLVAVGTHQALIASNALYARLAALQFSDGKAESELHL
>NZ_CP014870.1|WP_064676753.1|1890378_1892307_-|transglycosylase-SLT-domain-containing-protein
MRSRLFSLLSCFLLTATVVHTAQAVDLSTQRQYYDEAKRALAKGDSGPYFRYRQALSDYPLEPYLAYDELTARLKYASNAEIEQFLAEHGDLPQANWMKLRWLRWLSERGDWATFVKYYDPKMNFTELDCLNAQYQITHNQKAEGYANAQKLWLTGKSQPEACDTLFGIWAAEGQLTEQRRWERTKLAAQARNYPLANSLVNGLTTLAPRGRLLVEVAQKPELLNTPSRFIPADEPMSDVVSLGLRRLARQDPDRAMQMLDGYASSMHFSRDEKVAIAREIGLSLAKRFDPRALDMMTKYDPELRDNTVSEWRMRLLLRLARWDDAYQLSRRLPQDLATTNRWRYWQARSLELAQPQSPEVQTLYKGLARERDFYGFLAADRSQSPYSLNNKPLVLSQALINKVRNTPGIRRALEFHARGQIVDGRREWYHVSRHFNRDEMVAQAKLAYDLKWYFPAIRTISQAQYWDDLNIRFPMAHRETLVREAKVRGLHSSWVFAITRQESAFMDDARSSVGASGLMQLMPGTAKETARKFSIPLASPQQVFNPDKNIQLGAAYLSQVHAQFNGNRVLASAAYNAGPGRVRQWLRGADHLSFDVWVESIPFDETRQYVQNVLSYSVIYGQKLNSPQPLVDWHERYFDDQ
>NZ_CP014870.1|WP_064676754.1|1892520_1894437_+|ATP-binding-cassette-domain-containing-protein
MTLLKFSDVSLAFGAMPLLDKVSWQIARGERVCIIGRNGTGKSSMMKLVKGDQKPDEGSVWRAPGLKIGELPQELPVADERTVFDVVAEGLDGVGELLAQYHHLSQNIVTDADLDKLMHVQHDLEARDGWRLQQLVDSTLSRLQLPADKTLAELSGGWRRRVLLAQALVSEPDLLLLDEPTNHLDIGAIAWLEEALKDFQGAVLFITHDRSFLQNLATRILELDRGGLIDWNGDYASFLVHKEASLAAEETANALFDKKLAQEEVWIRQGIKARRTRNEGRVRALKALRVERSERRERTGKANIQLDTADKSGKQVMVLENVSFAHPGGPFLIKDFSMVLTRGDRIGLLGANGTGKTTLLKLMLSGLQPTSGTVEEGTRIDVAYFDQLRHQLDLEKTVIDNVAEGRDFIDIDGQSRHVLSYLGDFLFSPQRARTPVKALSGGERARLLLAKLFSKPANLLVLDEPTNDLDVETLELLEEVLLTFNGTVLMVSHDRAFLDNVVTSTLVFEGEGKVREYVGGYQDWLRQGGSPRLLGVTESKSGKADLTSAVVTAEPAPVAAVEAPVAKKKLSYKVQRELEALPGQIEAMEQQIAAVEAQMADAGFYQRPAAETAAVIAQLEQLNAELDIMVERWAELDA
>NZ_CP014870.1|WP_064676755.1|1894720_1895161_-|universal-stress-protein
MPYNHILVAVDLTEECDPVIHRARELSVSNGAKLSLVHIVEPMAMAFGGDVPMDLSQLQQQQFDQARDRLDRLIIKYPELSKEYSHLTYGQPRQEIHHLAKEQTCDLIVVGSHGRHGLALLLGSTANDVLHGAPCDVLAVRLQNKS
>NZ_CP014870.1|WP_064676756.1|1895366_1895804_+|hypothetical-protein
MTVWIVVSILLVVLSPLAWLRPSRGQSGRMALRMEARRIGLAMQLAPQDWPHWLSPEPPSPCAQYHRPRRGNQPACWSYWQKSPGEWVNQWQEACEDPVLLNHFEKLPGNVYKVEADKQMITLYWGEKGEADVLQQIDATLKALA
>NZ_CP014870.1|WP_064676757.1|1896434_1898582_+|fatty-acid-oxidation-complex-subunit-alpha-FadB
MIYEGKAITVKALESGIVELKFDLKGESVNKFNRLTLNELRQAVDTIKADNSIKGVIVSSGKDVFIVGADITEFVENFKLPDAELVAGNLEANRIFSDFEDLNVPTVAAINGIALGGGLEMCLAADYRVMANTAKIGLPEVKLGIYPGFGGTVRLPRIIGADNAIEWIAAGKENRAEDALKVGAVDAVVAPEKLLEAALNLVKGAISGEFDYKAKRQPKLEKLKLNAIEQMMSFETAKGFVAGQAGPNYPAPVEAIKTIQKAANFGRDKALEVEAAGFVKLAKTSAAQSLIGLFLNDQELKKKAKAYDEIAKDVKQAAVLGAGIMGGGIAYQSASKGTPILMKDINEHGIEQGLAEAAKLLVSRVDKGRMTAAKMAEVLNGIRPTLSYGDFGHVDLVVEAVVENPKVKQAVLAEVEGQVKEDTILASNTSTISITLLAKALKRPENFVGMHFFNPVHMMPLVEVIRGEKSSELAIATTVAYAKKMGKNPIVVNDCPGFLVNRVLFPYFGGFAKLVSAGVDFVRIDKVMEKFGWPMGPAYLMDVVGIDTGHHGRDVMAEGFPDRMKDDRRSAVDALYEAKRLGQKNGKGFYAYETDKNGKQKKVADPSVADVLKPIVFEQREVTDEDIVNWLMIPLCLETVRCLEDGIVETAAEADMGLVYGIGFPPFRGGALRYIDSIGVAEFVALADQYADLGALYHPTAKLREMAKTGQRFFG
>NZ_CP014870.1|WP_064676758.1|1898612_1899788_+|acetyl-CoA-C-acyltransferase-FadA
MSLNPRDVVIVDFGRTPMGRSKGGMHRNTRAEDMSAHLISKLLERNVKVDPNEVEDVIWGCVNQTLEQGWNIARMASLMTQIPHTAAGQTVSRLCGSSMSALHTAAQAIMTGNGDVFVVGGVEHMGHVSMMHGVDPNPHMSLHAAKASGMMGLTAEMLGKMHGITREQQDAFGLRSHQLAQKATVEGKFKDEIIPMQGYDENGFLKLFDYDETIRPETTLESLAALKPAFNPKGGTVTAGTSSQITDGASCMIVMSAQRAQDLGIQPLAVIRSMAVAGVDPAIMGYGPVPATHKALKRAGLGINDIDFFELNEAFAAQALPVLKDLKVLDKMNEKVNLHGGAIALGHPFGCSGARISGTLLNVMKQNGGTFGVATMCIGLGQGISTVFERV

Crispr_ID: NZ_CP014870_5

• CRISPR_ID: NZ_CP014870_5
• CRISPR_location: 1931238-1931364
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_5

Consensus_repeat	Method
CTGTAGGAGCAAGCTTGCTCCGGGCGGCGTTCCGACGATGGACGT	CRISPRCasFinder

spacers of NZ_CP014870_5

>5.1|1931283|37|NZ_CP014870|CRISPRCasFinder
CAACGATAACGCGTAGTCCCTGAACAAACGCAACCCC

CRISPR arrays and Neighbor proteins around NZ_CP014870_5

CRISPR arrays

The CRISPR arrays of NZ_CP014870_5

>merge|NZ_CP014870|5|1931238-1931364|CRISPRCasFinder
CTGTAGGAGCAAGCTTGCTCCGGGCGGCGTTCCGACGATGGACGTCAACGATAACGCGTAGTCCCTGAACAAACGCAACCCCCTGTAGGAGCGAGCTTGCTCCGGGCGGCGTTCCGACGATGGACGT

>NZ_CP014870|5|4|1931238-1931364|CRISPRCasFinder
CTGTAGGAGCAAGCTTGCTCCGGGCGGCGTTCCGACGATGGACGT	CAACGATAACGCGTAGTCCCTGAACAAACGCAACCCC
CTGTAGGAGCGAGCTTGCTCCGGGCGGCGTTCCGACGATGGACGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064676787.1|1933621_1934548_-|transaldolase	unknown	unknown	gnl|CDD|235381
NZ_CP014870.1|WP_064676780.1|1927443_1927965_+|cupredoxin-family-protein	unknown	unknown	gnl|CDD|259873
NZ_CP014870.1|WP_064676792.1|1938129_1939152_-|transketolase-family-protein	unknown	unknown	gnl|CDD|226467
NZ_CP014870.1|WP_064676788.1|1934726_1935713_-|tRNA-dihydrouridine(20/20a)-synthase-DusA	unknown	unknown	gnl|CDD|236991
NZ_CP014870.1|WP_064676779.1|1926607_1927288_-|heavy-metal-response-regulator-transcription-factor	unknown	unknown	gnl|CDD|130454
NZ_CP014870.1|WP_064676786.1|1932932_1933415_+|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NZ_CP014870.1|WP_064676793.1|1939148_1939997_-|transketolase	unknown	unknown	gnl|CDD|238970
NZ_CP014870.1|WP_064676782.1|1929334_1929598_-|DUF4404-family-protein	unknown	unknown	gnl|CDD|379579
NZ_CP014870.1|WP_167355116.1|1923144_1923828_+|lipoprotein-releasing-ABC-transporter-ATP-binding-protein-LolD	unknown	unknown	gnl|CDD|131266
NZ_CP014870.1|WP_064676778.1|1925258_1926608_-|heavy-metal-sensor-histidine-kinase	unknown	unknown	gnl|CDD|273593
NZ_CP014870.1|WP_064676784.1|1930542_1931232_+|VacJ-family-lipoprotein	unknown	unknown	gnl|CDD|377309
NZ_CP014870.1|WP_064676790.1|1936301_1936775_+|hypothetical-protein	unknown	unknown	gnl|CDD|227786
NZ_CP014870.1|WP_082930279.1|1937648_1938056_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676781.1|1928275_1929106_+|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	unknown	unknown	gnl|CDD|236986
NZ_CP014870.1|WP_064676789.1|1935897_1936251_+|type-II-toxin-antitoxin-system-HigB-family-toxin	unknown	unknown	gnl|CDD|378301
NZ_CP014870.1|WP_064676791.1|1936868_1937294_-|DUF2628-domain-containing-protein	unknown	unknown	gnl|CDD|313994
NZ_CP014870.1|WP_064676775.1|1921886_1923137_+|lipoprotein-releasing-ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|274034
NZ_CP014870.1|WP_064676783.1|1929723_1930344_-|hypothetical-protein	unknown	unknown	gnl|CDD|184075
NZ_CP014870.1|WP_064676785.1|1931751_1932933_+|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|381107
NZ_CP014870.1|WP_064676777.1|1923891_1925136_+|lipoprotein-releasing-ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|274034

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064676787.1|1933621_1934548_-|transaldolase	gnl|CDD|235381	PRK05269, PRK05269, transaldolase B; Provisional.	0
NZ_CP014870.1|WP_064676780.1|1927443_1927965_+|cupredoxin-family-protein	gnl|CDD|259873	cd04211, Cupredoxin_like_2, Uncharacterized Cupredoxin-like subfamily. Cupredoxins contain type I copper centers and are involved in inter-molecular electron transfer reactions. Cupredoxins are blue copper proteins because they have an intense blue color due to the presence of a mononuclear type 1 (T1) copper site. Structurally, the cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel. Some of these proteins have lost the ability to bind copper. Majority of family members contain multiple cupredoxin domain repeats; ceruloplasmin and coagulation factors V/VIII have six repeats; Laccase, ascorbate oxidase, and spore coat protein A, and multicopper oxidase CueO contain three repeats; and nitrite reductase has two repeats. Others are mono-domain cupredoxins, such as plastocyanin, pseudoazurin, plantacyanin, azurin, rusticyanin, stellacyanin, quinol oxidase and the periplasmic domain of cytochrome c oxidase subunit II.	5.00055e-47
NZ_CP014870.1|WP_064676792.1|1938129_1939152_-|transketolase-family-protein	gnl|CDD|226467	COG3958, COG3958, Transketolase, C-terminal subunit [Carbohydrate transport and metabolism].	4.89105e-147
NZ_CP014870.1|WP_064676788.1|1934726_1935713_-|tRNA-dihydrouridine(20/20a)-synthase-DusA	gnl|CDD|236991	PRK11815, PRK11815, tRNA dihydrouridine(20/20a) synthase DusA.	0
NZ_CP014870.1|WP_064676779.1|1926607_1927288_-|heavy-metal-response-regulator-transcription-factor	gnl|CDD|130454	TIGR01387, Transcriptional_regulatory_protein_PcoR, heavy metal response regulator. Members of this family contain a response regulator receiver domain (pfam00072) and an associated transcriptional regulatory region (pfam00486). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc. Most members encoded by genes adjacent to genes for encoding a member of the heavy metal sensor histidine kinase family (TIGRFAMs:TIGR01386), its partner in the two-component response regulator system. [Regulatory functions, DNA interactions].	1.18532e-109
NZ_CP014870.1|WP_064676786.1|1932932_1933415_+|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	5.14595e-13
NZ_CP014870.1|WP_064676793.1|1939148_1939997_-|transketolase	gnl|CDD|238970	cd02012, TPP_TK, Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.	2.4598e-127
NZ_CP014870.1|WP_064676782.1|1929334_1929598_-|DUF4404-family-protein	gnl|CDD|379579	pfam14357, DUF4404, Domain of unknown function (DUF4404). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two completely conserved residues (P and G) that may be functionally important.	9.55923e-22
NZ_CP014870.1|WP_167355116.1|1923144_1923828_+|lipoprotein-releasing-ABC-transporter-ATP-binding-protein-LolD	gnl|CDD|131266	TIGR02211, LolD_lipo_ex, lipoprotein releasing system, ATP-binding protein. This model represents LolD, a member of the ABC transporter family (pfam00005). LolD is involved in localization of lipoproteins in some bacteria. It works with a transmembrane protein LolC, which in some species is a paralogous pair LolC and LolE. Depending on whether the residue immediately following the new, modified N-terminal Cys residue, the nascent lipoprotein may be carried further by LolA and LolB to the outer membrane, or remain at the inner membrane. The top scoring proteins excluded by this model include homologs from the archaeal genus Methanosarcina. [Protein fate, Protein and peptide secretion and trafficking].	1.04815e-117
NZ_CP014870.1|WP_064676778.1|1925258_1926608_-|heavy-metal-sensor-histidine-kinase	gnl|CDD|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	1.03669e-151
NZ_CP014870.1|WP_064676784.1|1930542_1931232_+|VacJ-family-lipoprotein	gnl|CDD|377309	pfam04333, MlaA, MlaA lipoprotein. MlaA is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. MlaA is required for the intercellular spreading of Shigella flexneri. It is attached to the outer membrane by a lipid anchor.	1.6551e-103
NZ_CP014870.1|WP_064676790.1|1936301_1936775_+|hypothetical-protein	gnl|CDD|227786	COG5499, COG5499, Predicted transcription regulator containing HTH domain [Transcription].	6.76862e-10
NZ_CP014870.1|WP_064676781.1|1928275_1929106_+|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF	gnl|CDD|236986	PRK11792, queF, 7-cyano-7-deazaguanine reductase; Provisional.	0
NZ_CP014870.1|WP_064676789.1|1935897_1936251_+|type-II-toxin-antitoxin-system-HigB-family-toxin	gnl|CDD|378301	pfam09907, HigB_toxin, HigB_toxin, RelE-like toxic component of a toxin-antitoxin system. HigB_toxin is a family of RelE-like prokaryotic proteins that function as mRNA interferases. HigB cleaves translated mRNA only, and cleavage depended on translation of the target RNAs. HigB belongs to the RelE super-family of RNases. The toxin-antitoxin gene-pair is induced by environmental stress factors.	4.74341e-08
NZ_CP014870.1|WP_064676791.1|1936868_1937294_-|DUF2628-domain-containing-protein	gnl|CDD|313994	pfam10947, DUF2628, Protein of unknown function (DUF2628). Some members in this family of proteins are annotated as yigF however currently no function is known.	2.25635e-13
NZ_CP014870.1|WP_064676775.1|1921886_1923137_+|lipoprotein-releasing-ABC-transporter-permease-subunit	gnl|CDD|274034	TIGR02212, releasing_system_transmembrane_protein_lolC., lipoprotein releasing system, transmembrane protein, LolC/E family. This model describes the LolC protein, and its paralog LolE found in some species. These proteins are homologous to permease proteins of ABC transporters. In some species, two paralogs occur, designated LolC and LolE. In others, a single form is found and tends to be designated LolC. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_CP014870.1|WP_064676783.1|1929723_1930344_-|hypothetical-protein	gnl|CDD|184075	PRK13478, PRK13478, phosphonoacetaldehyde hydrolase; Provisional.	5.74725e-24
NZ_CP014870.1|WP_064676785.1|1931751_1932933_+|SpoIIE-family-protein-phosphatase	gnl|CDD|381107	cd17555, REC_RssB-like, phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains. Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	9.91794e-74
NZ_CP014870.1|WP_064676777.1|1923891_1925136_+|lipoprotein-releasing-ABC-transporter-permease-subunit	gnl|CDD|274034	TIGR02212, releasing_system_transmembrane_protein_lolC., lipoprotein releasing system, transmembrane protein, LolC/E family. This model describes the LolC protein, and its paralog LolE found in some species. These proteins are homologous to permease proteins of ABC transporters. In some species, two paralogs occur, designated LolC and LolE. In others, a single form is found and tends to be designated LolC. [Protein fate, Protein and peptide secretion and trafficking].	2.73014e-170

Protein sequences

>NZ_CP014870.1|WP_064676784.1|1930542_1931232_+|VacJ-family-lipoprotein
MRWSNHLAQLCVCASVLVVPFVAQAATEEDPWESINRPIYTFNDVLDTYALKPLAQGYQYVTPQFLEDGIHNMFRNVGDVTNLANNILQAKPASAGVDTARLIFNTTFGVLGFFDVGTKMGLQRNDEDFGQTLGYWGMGSGPYVMLPLLGPSTLRDAPSKYVDGYTGPYRYMDDVSVRNSVMGLNIIDTRANLLSAEKLIRGDKYTFIRNAYLQNREFKVKDGQVEDDF
>NZ_CP014870.1|WP_064676783.1|1929723_1930344_-|hypothetical-protein
MPLAEPKPLAAPSLTAVLFGLSGCLVDFGARTHRHGSHANAQAEVTPGALESLHDLQRQQIPCAWLDELPPALCDSLAAALPEWILPSQQLATINPWPAPDACWQALMRLKVERLEGCVLVSGEPRLLQSGLNAGLWTIGLASCGSLCGLAPHEWQALTHQERDMKRGKATVQLFGLGVHSVIDHLGELDTCLADISLRRLKGEKP
>NZ_CP014870.1|WP_064676782.1|1929334_1929598_-|DUF4404-family-protein
MPARDLQEQLNTLREQLEQNPPLTEAERADLHELMQQIELELELETKTQDSSLSDNVNLAVERFELEHPTLAGTLRNIVQALGNMGI
>NZ_CP014870.1|WP_064676781.1|1928275_1929106_+|NADPH-dependent-7-cyano-7-deazaguanine-reductase-QueF
MHPAAEHSPLGKSSEYIATYTPSLLFPIPRAAKWAELGLTAETLPYKGVDFWNCFELSWLLPSGKPVVAIGEFSIPADSPNIIESKSFKLYLNSLNQTPFADNAGLEATLVKDLSAAAGKPVGVRIRRLQEVEAEGVVALPGVCIDELDISVSNYEHPRPELLRCDESRIVEESVHSHLLKSNCPVTSQPDWGSVAVEYRGAALDHASLLEYIVSFRQHSDFHEQCVERIFLDLQRLLKPEKLTVYARYVRRGGLDINPYRSTEEVQLPNHRLVRQ
>NZ_CP014870.1|WP_064676780.1|1927443_1927965_+|cupredoxin-family-protein
MFLRKPLLLAACLLALGSPAWASPTHTFDFGQPAPAAKATRSVEVVMGDMSFTPKAIGIKAGETVRFVLVNKGQLLHEFNLGDVAMHARHQQEMLKMQQSGMLTPTGMKEMDHGAMPGMDHGMKHDDPNSVLVEPGKTAELTWTFTKGTELEFGCNVPGHYQAGMVGKLTVGP
>NZ_CP014870.1|WP_064676779.1|1926607_1927288_-|heavy-metal-response-regulator-transcription-factor
MKLLIVEDQPKTGHYLRQGLTEAGFNTELVADGSTGQQLALSGDYALLILDVMLPGRDGWQILQAVRGAGLDTPVLFLTARDAVEDRVHGLELGADDYLVKPFAFSELLARVRSLLRRGSATPQETSLQLADLRLDLIRRRVERNGQRIDLTAKEFALLEMLLRRQGEVLPKSLIASQVWDMNFDSDTNVIEVAIRRLRLKIDDEFPNKLIHTVRGMGYVLEERPA
>NZ_CP014870.1|WP_064676778.1|1925258_1926608_-|heavy-metal-sensor-histidine-kinase
MRRLSLSSRLALLFAACTAVVSLFAGVLFSRASEAHFVELDQQLLDGKLIGLRRALQDLQSSASEVKLADELSRQADLSLRITGSDGRRWYDSSPRLPATLPQQPGLSTLNDAGTDYRVLQAPLFPDRPDSPQLTLLLDITHHQHFLQRMQHLIWLTVGLSALATALLGAWAARSGLRPLRRMSAVARGVSAQSLNARLPETDMPPELAEMAHHFNAMLGRLDDSFQRLSAFSADIAHELRTPLSNLLTHTQVTLTRPRPIEDYREALHSNLEELQWMAQLVNDMLYLAKADHGLLMPRREPLDLAEEVDALLEFFAPLAEDAQVRLSRDGSAQMEGDRSMLRRALSNLLDNALRFTPAQGEVRVLIVEQPKVLSLTVENTGGGISEDLLPRLFDRFYRADPARHEGSNEHAGLGLAITRSIIRAHGGQIRCESDRGWTRFVIELPRGD
>NZ_CP014870.1|WP_064676777.1|1923891_1925136_+|lipoprotein-releasing-ABC-transporter-permease-subunit
MFRPLSIFIGMRYTRAKRRNRFVSFISMTSMIGLALGVLAMIVVLSVMNGFQREMSSRILGMVPHATIVGVNPIDDWQPVAAAAMKNPEVTAAVPFTEMEGMLSYKGTMQPIQVSGVDPALEGKVSIVAKHIVQGRLDALKPGEFGVVIGEITARRFRLNVGDKITLIVPEVSTAPGGITPRMQRLNVVGVFKVGAELDGSMALIHLADAAQMQHWEPNQVQSVRLAVKDLYAAPQVSGDVAAGLGSAYRADDWTHTQGSLFSAMKMEKTMIGLLLLMIVAVAAFNIIATLIMVVNDKGADIAILRTIGATPRQIMAIFMVQGTVIGVVGTLIGGVLGVIAALNVSELVGWVERVSGQHIFSSDVYFVSNLPSELQGADVLLICSAGFILSFLATVYPAWRAAKTEPATALRYS
>NZ_CP014870.1|WP_167355116.1|1923144_1923828_+|lipoprotein-releasing-ABC-transporter-ATP-binding-protein-LolD
MSDKAILSCRDLGKSYEEGPESVEVLAGLQLELHPGERVAIVGTSGSGKSTLLNLLGGLDTPTKGSVWLDGEELSALSEKNRGLLRNRSLGFVYQFHHLLPEFTALENVCMPLLIGKTSIPEARQRATALLERVGLGHRLEHKPAELSGGERQRVAIARALVNRPGLVMLDEPTGNLDSHTAQGIQDLMLELSVSMRTAFLVVTHDMNLARQMDRVLHLQEGCLTPI
>NZ_CP014870.1|WP_064676775.1|1921886_1923137_+|lipoprotein-releasing-ABC-transporter-permease-subunit
MFRPLFVFIGTRYTRAKRRNHFVSFISLTSIIGLALGVVVMIVVLSVMNGFDHEMRTRVLGMVPHATIESGEPINDWPGLAAKVKQNPQVTAVAPFTQMQGLLTNKGKVSKVLLNGIDPALERQVSIIDKFMLQGQLDALAPGSFGIVIGDKAAAKLGAAIGDKLTFVAPEVTVTPAGMFPRMKRFTVVGIFHVGAGEIDGYLGVTNLQDLGKLHRWKPEQVQGIRLKFDDLFQAPRTAWNIAQQLGEDHYYARDWTRTHGNLYQAIRMEKAMIGLLLLLIVAVAAFNIISTLVMVVNDKKGDIAILRTLGATPGSIMAIFMVQGTVIGVVGTLIGAVVGIFAALNVSAAIAALEGLIGHKFLNADVYFIDYLPSQVQSEDVLLVSAAALILSFLATLYPAWRAARTQPAEALRYE
>NZ_CP014870.1|WP_064676785.1|1931751_1932933_+|SpoIIE-family-protein-phosphatase
MPKTSATLLIIDDDEVVRASLAAYLEDSGFSVLQASNGQQGLQVFEQDKPDLVICDLRMPQMGGLELIRQVTERSPQTPVIVVSGAGVMNDAVEALRLGAADYLIKPLEDLAVLEHSVRRALDRARLLLENQRYREKLEKANRELEASLNLLQEDQNAGRQVQMNMLPVSPWTIDEFQFAHQIIPSLYLSGDFVDYFRVDERRVAFYLADVSGHGASSAFVTVLLKFMTTRLLFESKRSGTLPEFKPSEVLGHINRGLISCKLGKHVTMVGGVIDEETGLLTYSIGGHLPLPVLYTPDSVSYLEGRGLPVGLFNEATYEDHVLELPPTFSLTLMSDGILDLLPEPTLKEKEAALPQRVKAAGGSLDGLRQVFGLATLGEMPDDIALLVLSRNL
>NZ_CP014870.1|WP_064676786.1|1932932_1933415_+|STAS-domain-containing-protein
MSTGRIQFAEQDGTFVLKFVGEVRLTLCSALDATIERIFTSLNFNAIVIDLTETRSIDSTTLGLLAKLSILSRQKVGLLPTVVTTHEDITRLLQSMGFEQVFNIVDRPIPCPECLTDLPDQDQSEEVVRIKVLEAHKILMGLNDSNREAFHDLVNALERH
>NZ_CP014870.1|WP_064676787.1|1933621_1934548_-|transaldolase
MTSKLDQLKQMTTVVADTGDFEAIARVKPVDATTNPSLLLKAAAISGYAELLNACVHDCKGDVGLASDRFGVAVGQEILKVVPGRISTEVDARLSFDTDAVLKRAHRLIELYDKAGIGRDRVLIKIASTWEGIRAAEQLEKEGIQTNLTLLFSFAQAAACADAGVFLISPFVGRIYDWYKKANGNDYTGADDPGVQSVTRIYNYYKANDYKTVVMGASFRNLNQIEQLAGCDRLTISPELLEKLAADNGKLERKLAPGNAGEARLSLNEAQFRWLSNEDAMATEKLAEGIRQFARDQEKLEALLQAKL
>NZ_CP014870.1|WP_064676788.1|1934726_1935713_-|tRNA-dihydrouridine(20/20a)-synthase-DusA
MSLKTALLARRFSVAPMMDWTDRHCRFFLRLLSKHALLYTEMVTTGALLNGDHERFLRHNEAEHPLALQLGGSVPLDLAMCARMAQDHGYDEVNLNVGCPSDRVQNNMIGACLMGHPQLVADCVKAMRDAVSIPVTVKHRIGINGRDSYEQLCDFVGTVRDAGCTSFTVHARIAILEGLSPKENRDIPPLRYDVAARLKTDFPELEIILNGGIKTLEACREHLQTFDGVMLGREAYHNPYVMAEVDQQLFGSTAPVISRAEALAQLRPYIAAHIDAGGSMHHITRHVLGLGTGFPGARKFRQLLSVDIHKAKEPLVLLDQAAELLEGR
>NZ_CP014870.1|WP_064676789.1|1935897_1936251_+|type-II-toxin-antitoxin-system-HigB-family-toxin
MRVIAKAAVTQAMQKYSQWHAALSLWLTTFDKPGLRFESFEQTRNLWSATSGWNVDRVPRSKLRESSRKGPLDIYIFDIKKNECRIICWINTMNGTIYIKNILPHAGYDKWCKSEVE
>NZ_CP014870.1|WP_064676790.1|1936301_1936775_+|hypothetical-protein
MKRDKIEATGLDAFIANISPMLDGLSDQMATMSRLLSACHEKIKDDKDLQGRMALIDELYSHADSEGHVAARFAELVADRVYEYETETVLIPYSSQSEALAFLIADRGVKQKDLSEIASQSAISEMLNNKRKMTVSQIKGFSDYFKVPVEFFMHGVV
>NZ_CP014870.1|WP_064676791.1|1936868_1937294_-|DUF2628-domain-containing-protein
MSSTDELQNHDASPKWKERFAFFNQHGSPKNPTFSSALKQLTTRKRMLINMNFIAIFFGPVYLFVLGLWKKNLALIAIIVVVSFSLSLIFTILGRELPYALGSGLNVVFALMYGLSANYAYYLKQEKGSQGWNPFEGLKIV
>NZ_CP014870.1|WP_082930279.1|1937648_1938056_+|hypothetical-protein
MSTTKKLALMIAALYFSSFAQARELEVATGGATVTINGITYTGKNISVDGNRVVVDGVEQAVPVTGPVSVVVNGNPASVETAAGRVQVTGNVGSVRTMSGHVDSGDINGDVTTMSGDVSCKVHTGDTKTVSGNIR
>NZ_CP014870.1|WP_064676792.1|1938129_1939152_-|transketolase-family-protein
MNNATNTPTSMIEPPKKRLTTSAMIASIASEGQATRSAPFGHALAALADQRSDIVGMSADLSKYTDLHIFAKAHPDRFYQMGMAEQLLMSAAAGMAREGFVPFATTYAVFASRRAYDFICMAIAEENLNVKIVCGLPGLTTGYGPSHQATDDLAIFRAMPNLMIVDPCDALEIEQAVPAIAAHQGPVYMRLLRGNVPLVLDEYGYKFEIGKAKTLRTGNDVLIISTGLMTMRALEAAKELQADGVDVAVLHVPTIKPLDEQTILAEARKPGRLVITAENSSIIGGLGEAVATVLLRNGVTPTFRQIALPDAFLDAGALPTLHDRYGISTQAVCTQIKAWL
>NZ_CP014870.1|WP_064676793.1|1939148_1939997_-|transketolase
MTTHPSYASSKTLVQRAHNIRRHALQMGQVQGQGYVGQALGAADLLAVSYFHALNYRPENPQWEERDRFYLSIGHYAIALYAALIEAEIIPLDELQTYGSDDSRLPMSGMATYTPGMEITGGSLGQGLGIAVGACLGLKRKGSSSFVYNLLSDGELNEGSTWEAVMSASHWKLDNLIAIVDVNNQQADGYSSEILSFEPIVDRWQAFGWFTQRVDGNDLEALVAAFDAARNHPGTQPRVIICDTKMGKGVPFLENREKTHFIRVEEHEWDLALSNLEEGKNQ

Crispr_ID: NZ_CP014870_6

• CRISPR_ID: NZ_CP014870_6
• CRISPR_location: 2195050-2195144
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_6

Consensus_repeat	Method
GCTCGCGATGGTCGTTAACGATAACGCG	CRISPRCasFinder

spacers of NZ_CP014870_6

>6.1|2195078|39|NZ_CP014870|CRISPRCasFinder
TGTTTGCTGGTTAAACGCGGCGCTTGTAGGAGCAAGCTT

CRISPR arrays and Neighbor proteins around NZ_CP014870_6

CRISPR arrays

The CRISPR arrays of NZ_CP014870_6

>merge|NZ_CP014870|6|2195050-2195144|CRISPRCasFinder
GCTCGCGATGGTCGTTAACGATAACGCGTGTTTGCTGGTTAAACGCGGCGCTTGTAGGAGCAAGCTTGCTCGCGATGGTCGTTAACGAAAACGCG

>NZ_CP014870|6|5|2195050-2195144|CRISPRCasFinder
GCTCGCGATGGTCGTTAACGATAACGCG	TGTTTGCTGGTTAAACGCGGCGCTTGTAGGAGCAAGCTT
GCTCGCGATGGTCGTTAACGAAAACGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064676992.1|2195245_2196373_-|hybrid-cluster-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|99811
NZ_CP014870.1|WP_161491141.1|2186480_2186843_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_082930287.1|2190442_2191360_+|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213261
NZ_CP014870.1|WP_064676988.1|2189824_2190175_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|225981
NZ_CP014870.1|WP_064676990.1|2192398_2193427_+|glycine-betaine/L-proline-ABC-transporter-substrate-binding-protein-ProX	unknown	unknown	gnl|CDD|236852
NZ_CP014870.1|WP_064676997.1|2201474_2202257_-|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl|CDD|235812
NZ_CP014870.1|WP_064676999.1|2203769_2204165_-|type-II-toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl|CDD|224514
NZ_CP014870.1|WP_152032251.1|2204324_2204504_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676989.1|2191388_2192342_+|glycine-betaine/L-proline-ABC-transporter-permease-ProW	unknown	unknown	gnl|CDD|236805
NZ_CP014870.1|WP_064676995.1|2198783_2200235_-|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143415
NZ_CP014870.1|WP_064676993.1|2196378_2197635_-|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	unknown	unknown	gnl|CDD|176893
NZ_CP014870.1|WP_064676991.1|2193615_2194956_+|aminopeptidase-P-family-protein	unknown	unknown	gnl|CDD|223085
NZ_CP014870.1|WP_064676986.1|2187908_2189300_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274522
NZ_CP014870.1|WP_064676983.1|2185733_2186129_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676985.1|2186929_2187898_-|glycerate-dehydrogenase	unknown	unknown	gnl|CDD|240639
NZ_CP014870.1|WP_064676996.1|2200452_2201478_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|227311
NZ_CP014870.1|WP_064677001.1|2204597_2204957_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064676994.1|2197738_2198704_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|188320
NZ_CP014870.1|WP_064676998.1|2202267_2203587_-|FAD-binding-oxidoreductase	unknown	unknown	gnl|CDD|223737
NZ_CP014870.1|WP_064676987.1|2189472_2189814_-|RidA-family-protein	unknown	unknown	gnl|CDD|100007

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064676992.1|2195245_2196373_-|hybrid-cluster-NAD(P)-dependent-oxidoreductase	gnl|CDD|99811	cd06215, FNR_iron_sulfur_binding_1, Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal portion of the FAD/NAD binding domain contains most of the NADP(H) binding residues and the N-terminal sub-domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. In this ferredoxin like sub-group, the FAD/NAD sub-domains is typically fused to a C-terminal iron-sulfur binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins which act as electron carriers in photosynthesis and ferredoxins which participate in redox chains from bacteria to mammals. Ferredoxin reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.	6.85901e-116
NZ_CP014870.1|WP_064676994.1|2197738_2198704_-|LysR-family-transcriptional-regulator	gnl|CDD|188320	TIGR03418, chol_sulf_TF, putative choline sulfate-utilization transcription factor. Members of this protein family are transcription factors of the LysR family. Their genes typically are divergently transcribed from choline-sulfatase genes. That enzyme makes choline, a precursor to the osmoprotectant glycine-betaine, available by hydrolysis of choline sulfate.	6.80505e-72
NZ_CP014870.1|WP_082930287.1|2190442_2191360_+|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein	gnl|CDD|213261	cd03294, ABC_Pro_Gly_Betaine, ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system. This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporters is the obligatory coupling of ATP hydrolysis to substrate translocation. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.69361e-171
NZ_CP014870.1|WP_064676988.1|2189824_2190175_-|cupin-domain-containing-protein	gnl|CDD|225981	COG3450, COG3450, Predicted enzyme of the cupin superfamily [General function prediction only].	1.79397e-30
NZ_CP014870.1|WP_064676990.1|2192398_2193427_+|glycine-betaine/L-proline-ABC-transporter-substrate-binding-protein-ProX	gnl|CDD|236852	PRK11119, proX, proline/glycine betaine ABC transporter substrate-binding protein ProX.	1.38222e-178
NZ_CP014870.1|WP_064676997.1|2201474_2202257_-|NAD(P)-binding-domain-containing-protein	gnl|CDD|235812	PRK06476, PRK06476, pyrroline-5-carboxylate reductase; Reviewed.	8.36274e-34
NZ_CP014870.1|WP_064676989.1|2191388_2192342_+|glycine-betaine/L-proline-ABC-transporter-permease-ProW	gnl|CDD|236805	PRK10952, PRK10952, proline/glycine betaine ABC transporter permease ProW.	5.15257e-155
NZ_CP014870.1|WP_064676995.1|2198783_2200235_-|aldehyde-dehydrogenase-family-protein	gnl|CDD|143415	cd07097, ALDH_KGSADH-YcbD, Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like. Kinetic studies of the Bacillus subtilis ALDH-like ycbD protein, which is involved in d-glucarate/d-galactarate utilization, reveal that it is a NADP+-dependent, alpha-ketoglutaric semialdehyde dehydrogenase (KGSADH). KGSADHs (EC 1.2.1.26) catalyze the NAD(P)+-dependent conversion of KGSA to alpha-ketoglutarate. Interestingly, the NADP+-dependent, tetrameric, 2,5-dioxopentanoate dehydrogenase (EC=1.2.1.26), an enzyme involved in the catabolic pathway for D-arabinose in Sulfolobus solfataricus, also clusters in this group. This CD shows a distant phylogenetic relationship to the Azospirillum brasilense KGSADH-II (-III) group.	0
NZ_CP014870.1|WP_064676993.1|2196378_2197635_-|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	gnl|CDD|176893	cd08884, RHO_alpha_C_GbcA-like, C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases. C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs, also known as aromatic ring hydroxylating dioxygenases). RHOs utilize non-heme Fe(II) to catalyze the addition of hydroxyl groups to the aromatic ring, an initial step in the oxidative degradation of aromatic compounds. RHOs are composed of either two or three protein components, and are comprised of an electron transport chain (ETC) and an oxygenase. The ETC transfers reducing equivalents from the electron donor to the oxygenase component, which in turn transfers electrons to the oxygen molecules. The oxygenase components are oligomers, either (alpha)n or (alpha)n(beta)n. The alpha subunits are the catalytic components and have an N-terminal domain, which binds a Rieske-like 2Fe-2S cluster, and a C-terminal domain which binds the non-heme Fe(II). The Fe(II) is co-ordinated by conserved His and Asp residues. GbcA is involved in glycine betaine (GB) catabolism in Pseudomonas aeruginosa; it may remove a methyl group from GB via a dioxygenase mechanism, producing dimethylglycine and formaldehyde. This subfamily belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket.	5.30501e-80
NZ_CP014870.1|WP_064676991.1|2193615_2194956_+|aminopeptidase-P-family-protein	gnl|CDD|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	7.53964e-54
NZ_CP014870.1|WP_064676986.1|2187908_2189300_-|FAD-dependent-oxidoreductase	gnl|CDD|274522	TIGR03329, Phn_aa_oxid, putative aminophosphonate oxidoreductase. This clade of sequences are members of the pfam01266 family of FAD-dependent oxidoreductases. Characterized proteins within this family include glycerol-3-phosphate dehydrogenase (1.1.99.5), sarcosine oxidase beta subunit (1.5.3.1) and a number of deaminating amino acid oxidases (1.4.-.-). These genes have been consistently observed in a genomic context including genes for the import and catabolism of 2-aminoethylphosphonate (AEP). If the substrate of this oxidoreductase is AEP itself, then it is probably acting in the manner of a deaminating oxidase, resulting in the same product (phosphonoacetaldehyde) as the transaminase PhnW (TIGR02326), but releasing ammonia instead of coupling to pyruvate:alanine. Alternatively, it is reasonable to suppose that the various ABC cassette transporters which are also associated with these loci allow the import of phosphonates closely related to AEP which may not be substrates for PhnW.	2.12847e-171
NZ_CP014870.1|WP_064676999.1|2203769_2204165_-|type-II-toxin-antitoxin-system-HicB-family-antitoxin	gnl|CDD|224514	COG1598, COG1598, Predicted nuclease of the RNAse H fold, HicB family [General function prediction only].	1.86267e-05
NZ_CP014870.1|WP_064676985.1|2186929_2187898_-|glycerate-dehydrogenase	gnl|CDD|240639	cd12162, 2-Hacid_dh_4, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	4.70351e-121
NZ_CP014870.1|WP_064676996.1|2200452_2201478_+|helix-turn-helix-domain-containing-protein	gnl|CDD|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	1.06907e-82
NZ_CP014870.1|WP_064676998.1|2202267_2203587_-|FAD-binding-oxidoreductase	gnl|CDD|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	2.88649e-45
NZ_CP014870.1|WP_064676987.1|2189472_2189814_-|RidA-family-protein	gnl|CDD|100007	cd06150, YjgF_YER057c_UK114_like_2, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	3.24082e-36

Protein sequences

>NZ_CP014870.1|WP_064676991.1|2193615_2194956_+|aminopeptidase-P-family-protein
MMTSSFSIPADTRRIDPARRRAFKADGSVDDNDRTEIGPTPLAFAEWARSGLEAPHLATMREYRLQRLKDQLVARDLAGILLFDPLNIRYATDTTNMQLWTTHNPARACFVAASGHVVLWDFHGCNHLSAHLPLVSELRSGASFFYFETGDRTEQHAQGFAAQIDDLLRTHGGSNRRLAVDRIEVAGLRALDALGVQVHSGQEVTEFARVIKGPDEIKAMRCAVASCEGSIAEMRQAMRAGATENDVWAALHSGNIRRGGEWIETRILSSGPRTNPWYQESGPRVLSDGDLLSFDTDLIGVYGMCVDMSRSWICGGLEPSAEQKRLYRIAREHISFNTDLVRPGMGFTELTALGHRLPPSCREQRYGVMFHGVGLCDEYPCIRYPEDVGSYGYEGVLQPGMALCVEAYIGEVGGRDGIKLENQLLVTENGCEVLTRYPFESSFLQD
>NZ_CP014870.1|WP_064676990.1|2192398_2193427_+|glycine-betaine/L-proline-ABC-transporter-substrate-binding-protein-ProX
MHESTFTRRFLQCASALALSVVCLGASASADKPGEGVKITPAFPSVDEERFRGEIALAGLRELGYKVQPPKETEYATMVLAVGFGDADFTVNFWDKLHASFFQKAGGDENMVKAGDIMPGVLQGYVIDKKTADQYHIKYITDLKKPEIAKLFDTDGDGKADMTGCNPGWGCELVIEHQMKAYDLGKSIHVNQGSYFALMADTITRFKEGKPVFYYTWAPQWVAGVLVDGRDVVWLEVPKTDLPGGDNTVNTTYQGKNLGFAVDKVQALINRKFAEKNPAAVKYLSLVQIPAADESAQNLKMQQGEKSLADIQRHAREWIAAHQEQFDGWIKASRATATQASN
>NZ_CP014870.1|WP_064676989.1|2191388_2192342_+|glycine-betaine/L-proline-ABC-transporter-permease-ProW
MSDFSFLDPFQSATIPLGTWVESVLNYMVHNFRDVFRAIRWPIDQVLNGIEFALQSIPPSIGILLSSLLGWQLAGKRMALLCFVTLTLLGLIGVWSESMTTLALVLTSVFFCALIGIPLGIVCARSDSLERIIRPLLDAMQTLPAFVYLVPVVMLFGIGNVPGVLVTIVFALPPLVRLTNLGIRQVPEDKIEAARAFGCTPRQMLTRVQLPLASSTIMAGLNQTLMLSLSMVVIASMISVGGLGQMVLRGIGRLDMGLATVGGVGLVLLAIFLDRLTQAMGARTNADPSRRWFNTGPVGALLRLVGAGQPKVQRETA
>NZ_CP014870.1|WP_082930287.1|2190442_2191360_+|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein
MNHTDDILSVKNIYKVFGPNSDIAMKMLSDGADKEEIFKKTGHVVGVFNASFSVKRGEIFVIMGLSGSGKSTMVRLFNRLIEPTSGSIHLNGREITGLSDKALLDVRRKDMSMVFQSFALMPHMSVLENTAFGLEISGVSESERHARAREALAQVGLAGQEHSYPHQLSGGMQQRVGLARALANDPTILLMDEAFSALDPLIRQEMQGELIRLQAEQQRTIIFISHDIEEAVRIGHRIAIMEGGRVVQIGTPLELINQPANDYVRAFFKGFDVSRVLKASDVAQLDPAAVCRVCQKELDHTLSHH
>NZ_CP014870.1|WP_064676988.1|2189824_2190175_-|cupin-domain-containing-protein
MSQVLTVVRNAAASPLGETAPARLPIGEPIALAATGQAQTDDAVGASVGVWESSPGVFRRHLKNREFSHIVSGWCIFTPDGGEPVELRAGDAVLFPENCEGVWDIREALRKTYVLF
>NZ_CP014870.1|WP_064676987.1|2189472_2189814_-|RidA-family-protein
MIERINVGPRASQLVLVDGRIETSGIVALTPRHDIAEQTRCVLAQLEQWLAQAGASKANLTRLQIWLADMSEFAAMNEVYDAWVGDQPPVRACVGAALATPQYRIEIQAFGQL
>NZ_CP014870.1|WP_064676986.1|2187908_2189300_-|FAD-dependent-oxidoreductase
MYRGLWYAQALDLDSDLAPALQESIQADVCIVGGGYLGLWSAIRLKQANPEKTIVIVERDRCGAGASGRNGGIATNWWGKYLSLRTICGDVEARRICEAAESAINEIGSFCQEHGIDAQYRKDGWLWTATNPRQMNSWRVLTEGLQNLGVNPFQDMDRHTIQSRVGSPLVLGGIYDPNAATVQPAMLARGLRRVALKLGVKIYEKSPLTRLEQGANPVVHTERGTVRAHRVVLAMNAWGARFPELRRMIAIMSSDMVATAPVKARLDAIGFSGGECMTDSRTVLNYWRNTPDGRIVFGKPLGQFGFAGRIGNLYEKPSPAADKVCAEMRRLYPQLCDVPIVSSWTGPIDRAMKGLPNFGYLDHHQNIAYGIGFSGNGVATTVFASRIIKSLVEHANDEWANCGLVNQRMKLLPPEPFRFFGAHMVRDALVRKESLEDHDQDAGFVTRQLVAMAPAGYVPAQKK
>NZ_CP014870.1|WP_064676985.1|2186929_2187898_-|glycerate-dehydrogenase
MTEQIVFLDDEGLAPSTRLKRPACKHSWQQFAYTRPEQVIDHLQNATIALTCSVPLREEHLRHLPKLKMISLALTGRDIVDLDYCHAHGIEVTSVPGYAANTVAEHSLAMILELFRRPAAFTRLMRQVSTGEAPYQNIYFNHRIRDVRDKQLAIIGSGPIAMRLAHLARAFGMQVLFEDRGGKRPGPDCRPLAELLKSCDVLSINCPLTPETHNLIDVEQLALMKPDAVVVNTGRGGVINEAALIDALQNGRLGGVALDVVEHEPLHPSNPLFALIDRDDFLLNPHIAWSSEDAMQQLMDSAVDNISDFVARQGFGKRVSSG
>NZ_CP014870.1|WP_161491141.1|2186480_2186843_-|hypothetical-protein
MVYLVETLASVDAKRRLIYFRQKAINRSVTFSAIFQSPFPACHLFQLCNPSVRVKGLVVSTITIPIPIPIPIMPLIIITTIVSIMPMIIMTPFVATILVAPIMPVSTITVMPAAYKQDRA
>NZ_CP014870.1|WP_064676983.1|2185733_2186129_-|hypothetical-protein
MYWFRHHYRTLLRLTLGVWVLAVIVTAFHGCLVQPEHDLNATHATLSSLQQLDDHAQHASGCLKHCEDAAKAINPASKIPTVDLASLALALLLPAILLFTLTQPIAFAALALKRPAPPGPPARLIFVRFND
>NZ_CP014870.1|WP_064676992.1|2195245_2196373_-|hybrid-cluster-NAD(P)-dependent-oxidoreductase
MSLFENIASLRADQRFVDTDHWAAHGAQWASGDSKRIECLSVVAETHDVKTFVFHSPDYPALAYEPGQFLTVSPVIDGQSISRCYTLSSTPTRPFTFSITVKRVPGGAVSNWLHDNLKAGDAMAASGPAGVFTPVAGPARKLLYLSAGSGITPLMAMTRAAADLHADLDIVFVHSARTPKDIIFREELTRLERSMPRLRTLFFCEGLGDEPDWDGPIGRLSIDELQQRIPDFLERAVFTCGPKGYMDATKGLLGSAGFDLARYHQESFDISAEVVVEPVPSSEPGKAQDTFTVRLARSGKEFTMTADQTVLSAAKKAGAVVPSSCSQGVCGTCKTAVLEGSVEMKHNGGIRQREIDKGLRLLCCSRPTSDLVIDL
>NZ_CP014870.1|WP_064676993.1|2196378_2197635_-|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha
MNIAPIKTHREVITSRELGCGLSGEVFSRQDIFETDVDIFFTKHWILVAVTADIPEPGDVFTTDIGKSSILVLRDDDEQVRAYRNVCRHRGARLKEPGKSTVGMLVCPYHQWTYDLDGSLKHAAHMGKDFDPKCRSLIPVHCKVIGTHVFVCLSEEAPQDIAIQEEVMGARFAPYELTKTRIAYELDYIENGNWKLVMENNRECYHCAATHPELIVSYQSEDLGVSYEEMSEEARASYDAYQIRKAGIEANWESEGHLYATVEHLEENAATQFRTQRMIIAGSGESQTLDTKVACTRLLGNLTRRDLGDTHLWGNNGWTHVMSDHAMISWIIPLAPDRTLVRTKWLVHQDAVEGVDYDLQRLTEVWVATTRQDANLVAITHSGTQDPAYIPGPYSDFTEPYVDQFVRWYDARLAAHGV
>NZ_CP014870.1|WP_064676994.1|2197738_2198704_-|LysR-family-transcriptional-regulator
MKTQEAGSKHKGYRRIIPSMTALLQFESVARLESFTQAAMELGVTQAAVSKQIKVLEENVGAQLFHRLHRSIDLTNEGQALFAIISESLQKIATVFDQINQGAGRHEIKLGVTASFSQFQIMPRLARLRDALPDIQLRLATQMFTGDLRTQESDLYVRYGNGHWEDGEVIRLYEEEIFPVCSPGWLAKNPVPTTLEELASAGLLDSDSTSEGWMTWQGWFKELGLSTQKLNYILRGNQHSDVVHAALHGHGIGLGWGRVVEHLLATGELVRLEPFFIRPTDAYYAIIPDGRSATVEAWAVIRWLQDRAPLSSLSTASHNLM
>NZ_CP014870.1|WP_064676995.1|2198783_2200235_-|aldehyde-dehydrogenase-family-protein
MNPVTKSSYVDGAFISLDSASDLLENRNPSNPEEVIERFVRADQALTERAIAAARRAQPQWARSNPQQRADALDFIGSEILARREELAALLAREEGKVVREALGEVDRAARSFKFYAQEALRASGEKYQSVRQDVGIDVITQPLGVIGIIAPWNFPMAIPAWKIAPALCFGNCVVFKPAELVPSSAWALTEIIARAGLPAGVFNLLIGPGRSVGDTLIRSPQIDGISFTGSEHTGRQIARLAAEGMKKVQLEMGGKNPLIVLDDADLEQAVEVALNGSFYSTGQRCTASSRVIVTEGIHDAFVARLAQRTRALKVGDAMQASTDIGPVVDARQLEQNLSYVASGVEQGATLVCGGERIENAAGAHLFTPALFTDVRPDMRIYREEIFGPVLCVLKVRDYEAAYAAAEDTEFGLSAGIVTTSLRHAEHFKHHSSAGMVMVNLPTAGVDYHVPFGGNGASSLGSREQGTHARQFFTRVKTTYQLA
>NZ_CP014870.1|WP_064676996.1|2200452_2201478_+|helix-turn-helix-domain-containing-protein
MNTQPAEVKPDLRVGFVLMNQFTLVPVAGLVDSLRFAADKSFRSHQVYCQWDWMTCNDQPVIASCGMPISPTRPLNLFARYDYIVIAGGLLGETRNPPAWLLDALRDVHAANIPIIALCSASFVLGKAGLLDGRRCAVHFTIREEFQTLFPQAHSVIDKSYVEDRGIITCPGGTAIDLAASLIRRHCGEVRAQKGLEYLLVEERAEDEQQTNRVYQNDRVERAIAFMRDNLDVSLSLKAVADAVGTHPRQLHREFVANTQEPPANYWRKLRLDHARRLLVNTSQNVTTIALASGFSDASHFILWFRKQYGETPYSFRKHRHEVERFNTDRLSERVGMDPEL
>NZ_CP014870.1|WP_064676997.1|2201474_2202257_-|NAD(P)-binding-domain-containing-protein
MQSLGILGVGELTEKVVRGLRRSGFDGAILLSPRNAERARALAQACNCEVMSSNQAVVDNAAMLLLGVRPDSVAQLAAEITPKPGQHLLSLIAGLDLQTLQATFPGAVCVRVMLSYTAQFNQSTVVIYPPDETARICLGPLGSMVVMDDEPAFELATVAACMNGWFYFLFDDLQQWLVDKGLPVEQARTLVLGNLEDCLASARAHPDRSLKALGQAIATPGTYTAAGLDVLNHQPGSATWGAACEVVFDALLNRPPPPSN
>NZ_CP014870.1|WP_064676998.1|2202267_2203587_-|FAD-binding-oxidoreductase
MYRNTSTPADDNGCGWFHLSPPRDVRPGHSGRTEARWVVLGAGFTGLAAARQLALKFPQDEIVVIEGQQVGFGASGRNSGFAIDLPHDIGAHDYIGDPATARMNLKLNHFAQSMIRTLVEQYGIDCQIRADGKYQAAVEEKGLAVLQAYRSGLDKLGQAYEMIEARDLPEHLGTSFYRQALYTPGTLLLQPAALAMGLANNLPANVSLYENTVITHLEQGDKITLRHANGEFIAHELLLCNNAFASHFGFLPGRLLPIFTYASMTRPLSVEEQARLGGKETWGIIPADPFGSTLRRTPDQRLLVRNSFSFNASGQAQQRYLERAARQHRTSFDRRFPMLPDMPFDYTWGGSMCLSRNHSSYFGSLAPRVHGALCCNGLGITRGTATGTLLANWLAGEKDELTDFLLASPGPNRNPPEPLLSLGVNLNLNWGQRRAGLEA
>NZ_CP014870.1|WP_064676999.1|2203769_2204165_-|type-II-toxin-antitoxin-system-HicB-family-antitoxin
MYDFAIRFDQDATGVAVFCRDLPQLNSFGDNREHAISEAVDAIETTLSLYVDERRSIPQASSALENEHVVRLPAVTVAKIELWNEIVKRDMRKADLYRLLGVDHAQGDRLVDFLHVSEMEDLKAALLALKV
>NZ_CP014870.1|WP_152032251.1|2204324_2204504_-|hypothetical-protein
MLDSAQRRSLAALLLQASSVPIKNFNFKRIGEDVSEKLDYTPGVFVGERRMRNKGVKRV
>NZ_CP014870.1|WP_064677001.1|2204597_2204957_-|hypothetical-protein
MKKPSPNPPETDPVSTHESDLNKLGESAEQSFDFPIPSVADIKATPRTPSTLFTVDPEATTETLVVYLVETLASVDVMVHHLVDHLDGGSRNALLGISNSIMLAEITANRVLDQIDPLK

Crispr_ID: NZ_CP014870_7

• CRISPR_ID: NZ_CP014870_7
• CRISPR_location: 2721479-2721562
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_7

Consensus_repeat	Method
CTGTGGGAGCGGGCTTGCTCGCGA	CRISPRCasFinder

spacers of NZ_CP014870_7

>7.1|2721503|36|NZ_CP014870|CRISPRCasFinder
AAGCGGTGTATCAGGCAAATCAATGTCGACTGAACT

CRISPR arrays and Neighbor proteins around NZ_CP014870_7

CRISPR arrays

The CRISPR arrays of NZ_CP014870_7

>merge|NZ_CP014870|7|2721479-2721562|CRISPRCasFinder
CTGTGGGAGCGGGCTTGCTCGCGAAAGCGGTGTATCAGGCAAATCAATGTCGACTGAACTCTGTGGGAGCGAGCTTGCTCGCGA

>NZ_CP014870|7|6|2721479-2721562|CRISPRCasFinder
CTGTGGGAGCGGGCTTGCTCGCGA	AAGCGGTGTATCAGGCAAATCAATGTCGACTGAACT
CTGTGGGAGCGAGCTTGCTCGCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064677397.1|2716953_2717157_-|CbtB-domain-containing-protein	unknown	unknown	gnl|CDD|370526
NZ_CP014870.1|WP_064677395.1|2715824_2716238_-|cobalamin-biosynthesis-protein	unknown	unknown	gnl|CDD|376648
NZ_CP014870.1|WP_064677406.1|2731504_2732353_+|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|270413
NZ_CP014870.1|WP_064677396.1|2716234_2716942_-|CbtA-family-protein	unknown	unknown	gnl|CDD|227733
NZ_CP014870.1|WP_064677393.1|2710318_2714029_-|methionine-synthase	unknown	unknown	gnl|CDD|236539
NZ_CP014870.1|WP_064677403.1|2726580_2728134_-|MFS-transporter	unknown	unknown	gnl|CDD|129794
NZ_CP014870.1|WP_064677405.1|2729576_2731136_+|TerC-family-protein	unknown	unknown	gnl|CDD|223930
NZ_CP014870.1|WP_064677391.1|2708744_2709830_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380547
NZ_CP014870.1|WP_064677409.1|2733735_2734548_+|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224051
NZ_CP014870.1|WP_064677408.1|2733076_2733739_+|amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|223836
NZ_CP014870.1|WP_064677400.1|2723157_2724156_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|274135
NZ_CP014870.1|WP_082930308.1|2724080_2724821_+|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|224161
NZ_CP014870.1|WP_064677407.1|2732405_2733068_+|amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|223836
NZ_CP014870.1|WP_064677402.1|2724859_2726506_+|phospholipase	unknown	unknown	gnl|CDD|197270
NZ_CP014870.1|WP_045057579.1|2714349_2714934_+|Fe-S-biogenesis-protein-NfuA	unknown	unknown	gnl|CDD|132384
NZ_CP014870.1|WP_064677394.1|2714996_2715743_-|precorrin-4-C(11)-methyltransferase	unknown	unknown	gnl|CDD|225430
NZ_CP014870.1|WP_064677398.1|2718011_2719073_+|cobalamin-biosynthesis-protein-CobW	unknown	unknown	gnl|CDD|274151
NZ_CP014870.1|WP_064677404.1|2728299_2729166_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|182183
NZ_CP014870.1|WP_064677390.1|2706563_2708222_-|nitrite/sulfite-reductase	unknown	unknown	gnl|CDD|223233
NZ_CP014870.1|WP_064677392.1|2709852_2710071_-|DUF2970-domain-containing-protein	unknown	unknown	gnl|CDD|378581

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064677397.1|2716953_2717157_-|CbtB-domain-containing-protein	gnl|CDD|370526	pfam09489, CbtB, Probable cobalt transporter subunit (CbtB). This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of a single transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localization with a protein (CbtA) predicted to have five additional transmembrane segments.	1.50214e-16
NZ_CP014870.1|WP_064677395.1|2715824_2716238_-|cobalamin-biosynthesis-protein	gnl|CDD|376648	pfam01890, CbiG_C, Cobalamin synthesis G C-terminus. Members of this family are involved in cobalamin synthesis. The protein encoded by Synechocystis sp.cbiH represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyze adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD, it is therefore possible that CbiG catalyzes a reaction step adjacent to CbiH. In the anaerobic pathway such a step could be the formation of a gamma lactone, which is thought to help to mediate the anaerobic ring contraction process. Within the cobalamin synthesis pathway CbiG catalyzes the both the opening of the lactone ring and the extrusion of the two-carbon fragment of cobalt-precorrin-5A from C-20 and its associated methyl group (deacylation) to give cobalt-precorrin-5B. This family is the C-terminal region, and the mid- and N-termival parts are conserved independently in other families.	3.80248e-41
NZ_CP014870.1|WP_064677406.1|2731504_2732353_+|transporter-substrate-binding-domain-containing-protein	gnl|CDD|270413	cd13695, PBP2_Mlr3796_like, The substrate-binding domain of putative amino aicd transporter; the type 2 periplasmic binding protein fold. This group includes the periplamic-binding protein component of a putative amino acid ABC transporter from Mesorhizobium loti and its related proteins. The putative Mlr3796-like domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.83683e-145
NZ_CP014870.1|WP_064677396.1|2716234_2716942_-|CbtA-family-protein	gnl|CDD|227733	COG5446, COG5446, Predicted integral membrane protein [Function unknown].	5.09432e-92
NZ_CP014870.1|WP_064677393.1|2710318_2714029_-|methionine-synthase	gnl|CDD|236539	PRK09490, metH, B12-dependent methionine synthase; Provisional.	0
NZ_CP014870.1|WP_064677403.1|2726580_2728134_-|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	5.71333e-59
NZ_CP014870.1|WP_064677405.1|2729576_2731136_+|TerC-family-protein	gnl|CDD|223930	COG0861, TerC, Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism].	2.01996e-96
NZ_CP014870.1|WP_064677391.1|2708744_2709830_+|ABC-transporter-substrate-binding-protein	gnl|CDD|380547	cd06324, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of uncharacterized ABC-type transport systems. This group includes the periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	3.91581e-137
NZ_CP014870.1|WP_064677409.1|2733735_2734548_+|amino-acid-ABC-transporter-ATP-binding-protein	gnl|CDD|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	2.96655e-141
NZ_CP014870.1|WP_064677408.1|2733076_2733739_+|amino-acid-ABC-transporter-permease	gnl|CDD|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.93215e-68
NZ_CP014870.1|WP_064677400.1|2723157_2724156_+|AAA-family-ATPase	gnl|CDD|274135	TIGR02442, Uncharacterized_protein_Rv2850c/MT2916, cobaltochelatase subunit. Cobaltochelatase is responsible for the insertion of cobalt into the corrin ring of coenzyme B12 during its biosynthesis. Two versions have been well described. CbiK/CbiX is a monomeric, anaerobic version which acts early in the biosynthesis (pfam06180). CobNST is a trimeric, ATP-dependent, aerobic version which acts late in the biosynthesis (TIGR02257/TIGR01650/TIGR01651). A number of genomes (actinobacteria, cyanobacteria, betaproteobacteria and pseudomonads) which apparently biosynthesize B12, encode a cobN gene but are demonstrably lacking cobS and cobT. These genomes do, however contain a homolog (modelled here) of the magnesium chelatase subunits BchI/BchD family. Aside from the cyanobacteria (which have a separate magnesium chelatase trimer), these species do not make chlorins, so do not have any use for a magnesium chelatase. Furthermore, in nearly all cases the members of this family are proximal to either CobN itself or other genes involved in cobalt transport or B12 biosynthesis.	1.05592e-120
NZ_CP014870.1|WP_082930308.1|2724080_2724821_+|VWA-domain-containing-protein	gnl|CDD|224161	COG1240, ChlD, Mg-chelatase subunit ChlD [Coenzyme metabolism].	4.5853e-35
NZ_CP014870.1|WP_064677407.1|2732405_2733068_+|amino-acid-ABC-transporter-permease	gnl|CDD|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.53607e-68
NZ_CP014870.1|WP_064677402.1|2724859_2726506_+|phospholipase	gnl|CDD|197270	cd09173, PLDc_Nuc_like_unchar1_2, Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium. Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins, which show high sequence homology to the endonuclease from Salmonella typhimurium and vertebrate phospholipase D6. Nuc and PLD6 belong to the phospholipase D (PLD) superfamily. They contain a short conserved sequence motif, the HKD motif (H-x-K-x(4)-D, where x represents any amino acid residue), which characterizes the PLD superfamily and is essential for catalysis. Nuc and PLD6 utilize a two-step mechanism to cleave phosphodiester bonds: Upon substrate binding, the bond is first attacked by a histidine residue from one HKD motif to form a covalent phosphohistidine intermediate, which is then hydrolyzed by water with the aid of a second histidine residue from the other HKD motif in the opposite subunit. However, proteins in this subfamily have two HKD motifs in a single polypeptide chain.	9.50262e-42
NZ_CP014870.1|WP_045057579.1|2714349_2714934_+|Fe-S-biogenesis-protein-NfuA	gnl|CDD|132384	TIGR03341, YhgI_GntY, IscR-regulated protein YhgI. IscR (TIGR02010) is an iron-sulfur cluster-binding transcriptional regulator (see Genome Property GenProp0138). Members of this protein family include YhgI, whose expression is under control of IscR, and show sequence similarity to IscA, a known protein of iron-sulfur cluster biosynthesis. These two lines of evidence strongly suggest a role as an iron-sulfur cluster biosynthesis protein. An older study designated this protein GntY and suggested a role for it and for the product of an adjacent gene, based on complementation studies, in gluconate utilization. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	4.93843e-120
NZ_CP014870.1|WP_064677394.1|2714996_2715743_-|precorrin-4-C(11)-methyltransferase	gnl|CDD|225430	COG2875, CobM, Precorrin-4 methylase [Coenzyme metabolism].	2.10321e-131
NZ_CP014870.1|WP_064677398.1|2718011_2719073_+|cobalamin-biosynthesis-protein-CobW	gnl|CDD|274151	TIGR02475, Probable_cobalamine_biosynthesis_protein, cobalamin biosynthesis protein CobW. The family of proteins identified by this model is generally found proximal to the trimeric cobaltochelatase subunit CobN which is essential for vitamin B12 (cobalamin) biosynthesis. The protein contains an P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. A broader CobW family is delineated by two Pfam models which identify the N- and C-terminal domains (pfam02492 and pfam07683). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	0
NZ_CP014870.1|WP_064677404.1|2728299_2729166_+|LysR-family-transcriptional-regulator	gnl|CDD|182183	PRK09986, PRK09986, LysR family transcriptional regulator.	1.2111e-44
NZ_CP014870.1|WP_064677390.1|2706563_2708222_-|nitrite/sulfite-reductase	gnl|CDD|223233	COG0155, CysI, Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism].	0
NZ_CP014870.1|WP_064677392.1|2709852_2710071_-|DUF2970-domain-containing-protein	gnl|CDD|378581	pfam11174, DUF2970, Protein of unknown function (DUF2970). This short family is conserved in Proteobacteria. The function is not known.	1.33048e-22

Protein sequences

>NZ_CP014870.1|WP_064677398.1|2718011_2719073_+|cobalamin-biosynthesis-protein-CobW
MKTLAKLPVTIVTGFLGSGKTTLLRHMLDNAQGRRIAVIVNEFGELGIDGEILKQCTIGCTEEEASGRVYELANGCLCCTVQEEFFPVMRELVARRGDLDHILIETSGLALPKPLVQAFQWPEIRSACTVDAVITVVDSPAVAAGTFAAFPDQVDAMRKLDPNLDHESPLHELFADQLASADLVILNKADLISPEDLARVRLEVAEELPPAVKVIEASSGRLPLDVLIGLGAGSEEHIDSRHSHHDHHHEGEDDHDHDAFDSISIELPQADESLLLDALTQLVVQHGILRVKGFAAIPGKPMRLLIQGVGTRFDKHFDRQWGADEARTTRLVLIGQELDAALLEAQLRAALSV
>NZ_CP014870.1|WP_064677397.1|2716953_2717157_-|CbtB-domain-containing-protein
MSIISSTGSNTDKSTASSTTTLTQRLTAAACASILGACLVYFAGFSHIESVHNAAHDTRHSAAFPCH
>NZ_CP014870.1|WP_064677396.1|2716234_2716942_-|CbtA-family-protein
MIKRIAQTAGFSGLLAALLLTLLQSFWVSPLIMQAETYEKSEPAAVEIHEHAAGAVVAHTHDAEAWEPEDGWQRVLSTTGGNLVVAVGFALMLAGLYTLRAPTKTSQGLLWGLAGYATFVLAPTLGLPPELPGTAAADLAQRQIWWIGTAASTAAGIALIVFSRHWLMKVLGAAILAVPHVIGAPQPEVHSMLAPQALESQFKIASQLTNVAFWLALGLVSAWLFRRKSDGQYQA
>NZ_CP014870.1|WP_064677395.1|2715824_2716238_-|cobalamin-biosynthesis-protein
MTDNSAVPTLVVGLGCQRGCPVSTLRALLDQALQAHRIELSQVKALASIDLKREEPGLIELAAQLELPLMYFSSEQLAGYQPQLSHRSDIAFERTGCYGVAESAALALAEQLAQAPAKLLISRQKYAQATLALAGAA
>NZ_CP014870.1|WP_064677394.1|2714996_2715743_-|precorrin-4-C(11)-methyltransferase
MTVYFIGAGPGDPELITVKGQRLIRSCPVIIYAGSLVPAAVLEGHQAEQLVNSAELHLEQIIELIKSAHAKGQDVARVHSGDPSLYGAIGEQIRYLRELDIAFEIIPGVTATAACAALLGAELTLPDVSQSVILTRYADKTSMPAGEELGSLAQHGATMAVHLGVNHLQKILVELLPHYGADCPIAVIHRATWPDQDWVVGTLEDIAGKVEAKGFRRTALILVGRVLGSDHFSESSLYRAGHAHLYRP
>NZ_CP014870.1|WP_045057579.1|2714349_2714934_+|Fe-S-biogenesis-protein-NfuA
MTAITITDAAHDYLADLLSKQNTPGIGIRVFITQPGTQYAETCIAYCKPGEEKPEDTALGLKSFTAYIDSFSEAFLDDAVVDYATDRMGGQLTIKAPNAKVPMVNADSPINERINYYLQTEINPGLASHGGQVSLIDVVDDGIAVLKFGGGCQGCGQADVTLREGIERTLLERVPELKGVRDVTDHTQKENAYY
>NZ_CP014870.1|WP_064677393.1|2710318_2714029_-|methionine-synthase
MSDRSVRLQALKHALKERILILDGGMGTMIQSYKLEEQDYRGKRFADWPSDVKGNNDLLILTRPDVIGSIEKAYLDAGADILETNTFNATQVSQADYGMQGLAYELNVEGARLARQVADAKTLETPDKPRFVAGVLGPTSRTCSLSPDVNNPGYRNVTFDELVENYTEATKGLIEGGADLILIETIFDTLNAKAAIFAVQGVYEELGVELPIMISGTITDASGRTLSGQTTEAFWNSVAHAKPISVGLNCALGASELRPYLEELSNKAGTYVSAHPNAGLPNEFGEYDELPAETAKVIEEFAQSGFLNIVGGCCGTTPGHIEAIAKAVAGYAPREIPEIPKACRLSGLEPFTIDRSSLFVNVGERTNITGSAKFARLIRDDNYTEALEVALQQVEAGAQVIDINMDEGMLDSKKAMVTFLNLIAGEPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGVEQFIQHAKLCKRYGAAVVVMAFDEAGQADTEARKKEICKRSYDILVNEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFINACAYIRDELPYALTSGGVSNVSFSFRGNNPVREAIHSVFLLYAIRNGLTMGIVNAGQLEIYDQIPAELRDAVEDVILNRTPEGTDALLAIADKYKGDGSVKEAETEEWRNWDVNKRLEHALVKGITTHIVEDTEESRQSFARPIEVIEGPLMSGMNIVGDLFGAGKMFLPQVVKSARVMKQAVAHLIPFIELEKGDKPEAKGKILMATVKGDVHDIGKNIVGVVLGCNGYDIVDLGVMVPAEKILQVAKEQKCDIIGLSGLITPSLDEMVHVAREMQRQDFHLPLMIGGATTSKAHTAVKIEPKYSNDAVIYVTDASRAVGVATQLLSKELKPAFVEKTRLEYIEVRERTANRSARTERLSYPAAIAKKPQFDWSTYTPVKPTFTGAKVLDNIDLKVLAEYIDWTPFFISWDLAGKFPRILTDEVVGEAATSLYADAQEMLAKLIDEKLISARAVFGFWPANQVRDDDIELYGDDGKPLAKLHHLRQQIIKTDGKPNFSLADFVAPKDSEVTDYVGGFITTAGIGAEEVAKAYQDAGDDYNSIMVKALADRLAEACAEWLHQQVRKNYWGYAKDETLDNEALIKEQYTGIRPAPGYPACPDHTEKGTLFALLDPQASEMQAGRSGVFLTEHYAMFPAAAVSGWYFAHPQAQYFAVGKIDKDQVQSYTSRKGQELSVTERWLAPNLGYDN
>NZ_CP014870.1|WP_064677392.1|2709852_2710071_-|DUF2970-domain-containing-protein
MDDPVDNKPPSFWQMLHSVMAAAFGVQSGKNRARDFTHGKPSHFVILGIVFTAVFALTLFGIVKLVLHLAGI
>NZ_CP014870.1|WP_064677391.1|2708744_2709830_+|ABC-transporter-substrate-binding-protein
MLKFFCGVLLALGTMVAPCTQAASVLFLNPGTTGEAFWLSYSQFMQAAARDLAMDLRIQYADHLAETTLAQAREALQGPGRPDYLVFVNEQYVAPEILRLAQGSGVKLFMVNNALTPDQMSLLGSQPEKYPDWLGSLVPNDEEGGYLMLKELIRLHPPAAPGQVIELLAFSGLKVTPAAQLREKGMMRALAEHPEVRLRQLVYGGWTRERAYEQAGLLFKRYPRASLVWTANDEMAFGVMQAYVEAGGEPGKDALFGTINHSPAALRALLDGRLSVLLGGHFSLGGWALVQLHDYDQGVDFGQYGGRDRQIPLLQLIDRAQAERLLTLGVRQDYGVDFQKLSAKGQPASYRYPFSLQTLLH
>NZ_CP014870.1|WP_064677390.1|2706563_2708222_-|nitrite/sulfite-reductase
MYVYDEYDQRIIEDRVKQFRDQTRRYLAGELSEEEFRPLRLQNGLYIQRFAPMLRVAVPYGQLTSRQTRMMAKIARDYDKGYAHISTRQNVQFNWPALEDIPDILAELATVQMHAIQTSGNCLRNVTTDQFAGVAADELIDPRPWCEIVRQWTTFHPEFAYLPRKFKIAINGSTSDRAAIEVHDIGLEAVRNAAGEIGFRVLVGGGLGRTPVVGAFINEFLPWQDLLSYLDAILRVYNRYGRRDNKYKARIKILVKALTPEVFAQKVEAEMEHLRGGQTTLTEAEVHRVAKHFVDPEYKALDNQSAELAKLDKQHPGFARWRTRNTLAHKKPGYVAVTLSLKPTGVAPGDITDKQLDAVADLAERYSFGQLRTSHEQNIILADVEQGRLFEMWGELREQGFATPNIGLLTDIICCPGGDFCSLANAKSIPIAESIQRRFDDLDYLFDIGELDLNISGCMNACGHHHVGHIGILGVDKKGEEFYQVSLGGSGTRDASLGKILGPSFAQDVMPDVIEKLIDVYIEQRTEDERFIDTYQRIGIDLFKERVYAANN
>NZ_CP014870.1|WP_064677400.1|2723157_2724156_+|AAA-family-ATPase
MTDTPHFPLSAVVGADDLKLALYLTAIDPKIGGVLIEGPRGMAKSTLARGLADLLASGQFVTLPLGATEERLVGTLDLDAALSEGRAQFSPGVLAKADGGVLYVDEVNLLPDHLVDLLLDVAASGTNLIERDGISHRHSAKFVLIGTMNPEEGELRPQLLDRFGLNVALSGHTVPAERGQIIRRRLDFDSDPQLFCVEWESRQQSLRERCQTARSTLASIPLDDQALAQITERCFAAGVDGLRADLVWLRAARAHAAWRGASAIAEEDIDAVAEFALRHRRREQAPPAPQHNQPQAGQHANPGESQGQWGEMPAQALPVGARREVPSWPKKP
>NZ_CP014870.1|WP_082930308.1|2724080_2724821_+|VWA-domain-containing-protein
MGRNARPGLAGRRPTRSAELAKKALGIRPRSDAGANARPRAGRLDNGRQGKRHAARNGSINWPGTLLGGRPRQRDDVLFHLRTRSPHELWLVIVDASASTRRHQALSDAKGLLAQLFDDAYRQRARLALLTASGHVPKWQVQGLKASAGLRTWLDGLGAGGGTPLLAALGEAGHWLAARRKRFPAERQRLLLVTDGRLKDFTMLPTLDCPGLLIDIERGPIRLGRAKVLASGLGADYRHIDELIPG
>NZ_CP014870.1|WP_064677402.1|2724859_2726506_+|phospholipase
MRVLAANHQDDFRVKAYAGTNGVLLAMDLAEPRRKGLLGFAIEKQQGSKPWLFLFNSLTFPGKVHTFAHFRATPSNIAPLQKFRWADYAVNPGMTIHYRVHLAYGSADAPQLGEYLELTVTSDNGQPQNQSVIFNRAVAASQAFQRKFPDLDAMISANKNLPIEAWPDAPRQWLENGLLGRLLGFIERAVDDQWALDIAIYEYELRVIVDAIDAAFERGVKVRVLYHAKSGDKGTARNEESLEKIPQTSKRGRVTHKIFHNKFMVLSRLDDTGQHQPEAVLSGSTNFTANGVYRQANVVHVLDDAQVSASYLQTFEQVWATPENVGATRKWLTHHNPMDSLQPLFSGFSPRSGRGDLQAFVDIIDAAKKDVLFVTAFALPDDILNALLGQPEDDILRYGLQNTTSRITGFHADRTAEFAATALLNTGLEGWLRENMKGQKGNLLVHTKAVVTDFTSDAPTIISGSHNLSASASNGNDENYLIIRGNTDLADRYGLELLRFYEHYRFRYFAKKLALKQVQPLAADDSWTDDYYRAGDLRRLSRLRFSGR
>NZ_CP014870.1|WP_064677403.1|2726580_2728134_-|MFS-transporter
MSRVSPRLTLLTASGVCSLIVLDTNIVAVTLPTIARDLGANFADIEWVVSAYMLAFAALLLPAGSIADRFGRQKTLLWGLGIFILASIGCGAAPNALLLDIARAIKGVGAALLLTSALASIGHTFHDEVERAKAWAFWGACMGVAMTAAPTVGGLITEYMGWRWIFYLNLPVGLFLMAMVWRAVPESRDTQSARLDPWGSLAFSASLLCLIWGLIEANRIGWSNPLTYARLIGGALLLGLFVVIERLQQRPMVDLQLFKHPRFIGALLGMFAYAGCAQVMMTLLPFYLQNGLGFSAIASGLGMLPFALTMLICPRIGVRLASRFAPATMMAAGLTLVGSGNLLSAWAVGSGGYLPFALAIAVTGAGAGLLNGDTQKNIMACVPRARTGMASGMSTTMRFSAIVLAIGVFGALLSSHTELLLRSSLSAQGAPWLDQTQGIASRVVAGDMSAAMGLVPDTARSLVEPLARQAFVGGFSLLLWVAGLLALLGALVVGTLMRHPIPAANASVSAASHRTPA
>NZ_CP014870.1|WP_064677404.1|2728299_2729166_+|LysR-family-transcriptional-regulator
MDIRHFRYFLAVARQGNFTRAAEQLGIAPPTLTRQIQDMENELGTRLFVRQTREVSLTEAGTALLIEAEATVRQFEYAQHNAQRAGRGDIGHIELGYVASAVYSGLLQKQVQAFSRECPDVSLNVRESPMASLPMMVVEGRFDIGYVRSPMTFPEGLEAIRLDAEGFVLALPSESWLCRLPEIAPEHLQNETFILPEQISGTLQVAAEGGFAPKLGAQPGGLVAVIALVSLGQGVAVVPESVVGHVGLPGVLYRSIKGCEASSWLSLIHRRFEKSAAVARYIEQVKNR
>NZ_CP014870.1|WP_064677405.1|2729576_2731136_+|TerC-family-protein
MEWIADPTAWLGLLTLIVLELVLGIDNLVFIAILADKLPPEQRDRARIIGLSLALLMRLGLLASISWLVTLTQPLFEVFDKSFSGRDLIMLFGGVFLLFKATMELHERLEGHVGERSSNTAYALFWPIVAQIVVLDAVFSLDAVITAVGMVDELAVMMIAVIISIGLMIVASKPLTRFVNAHPTVIMLCLGFLMMIGFALTAEGLGFHIPKGYLYAAIGFSILIEVFNQIARARRKRSMQGLRPMRERTAHAVMRLLGGRKLAAEEVGEEIADMLDNGEVPGGELFDRRERVMISGVLQLAERPIRTLMTVRADVDHIDLADDAETIRTRLMHSSYSRLPLIRDGAVDEPLGFVHKKELLKEYLAGNEPGLEDLARKTINLLDSYSILNALEQMRKASTHIAFVVNEFGDFVGVLTMTDILESIAGELPDASEIEGPDVVEEQGGFVVSGALNLARVRQRTGFAAEPTDDYQTLAGLVVSVLDRLPMIGDSHEWEGWRLTVMAVEERRVTRVLLAPVGG
>NZ_CP014870.1|WP_064677406.1|2731504_2732353_+|transporter-substrate-binding-domain-containing-protein
MHRRPSLFKACVFLFAASAAAVGVAQAADNKLDSVLARGKLIVGTGSTNAPWHFQGADGKLQGFDIDIARMVAKGLFNDPSKVEFVVQSSDARIPNLLTDKVDMSCQFITVTASRAQQVAFTLPYYREGVGLLLPANSKYKEIEDLRAAGDDVTVAVLQNVYAEELVHQALPKAKVDQYDSVDLMYQAVNSGRADAAATDQSSVKYLMVQNQGRYRTPAYAWSPQTYACAVKRGDQDWLNFVNTALHEAMTGVEFPTYAASFKQWFGVDLPTPAIGFPAEYK
>NZ_CP014870.1|WP_064677407.1|2732405_2733068_+|amino-acid-ABC-transporter-permease
MNYQLNFAAVWRDFDTLLVGLGLGLQLALVSIAIGCVIGLLMAFALLSRHRALRVLASVYVTVVRNTPILVLILLIYFALPSLGIRLDKIPSFIITLSLYAGAYLTEVFRGGLLSIPKGQREAGLAIGLGEWQVKAYVTVPVMLRNVLPALSNNFISLFKDTSLAAAIAVPELTYYARKINVESYRVIETWLVTTALYVAACYLIAMLLRYFEQRLAIRR
>NZ_CP014870.1|WP_064677408.1|2733076_2733739_+|amino-acid-ABC-transporter-permease
MYESPSWLHELWVAREVLWQGFLTSVQVSALAIVLGTMVGIVTGLVLTYGKFWMRAPFRFYVDVIRGTPVFVLVLACFYVAPALGWQISAFQAGALGLTLFCGSHVAEIVRGALQALPSGQMEASKAIGLTFFQSLGYVLLPQALRQILPTWVNSSTEIVKASTLLSVIGVAELLLSTQQIIARTFMTLEFYLFAGLLFFVINYGIELLGRHIEKRVALP
>NZ_CP014870.1|WP_064677409.1|2733735_2734548_+|amino-acid-ABC-transporter-ATP-binding-protein
MTQTQRSNATDPRAQNGQPLLDIRGLHKQYGQLEVLKGVDLTMQRGNVVTLIGSSGSGKTTLLRCVNMLEEFQGGQILLDGESIGYDEVNGKRVRHPEKVIARHRAMTGMAFQQFNLFPHLTALQNVTLGLLKVKKLHKDEAVTLAEKWLERVGLLDRRDHYPGQLSGGQQQRVAIARAIAMNPSLMLFDEVTSALDPELVGEVLNVIKGLAEDGMTMLLVTHEMRFAFEVSDKIVFMNQGRIEEQGPPKELFERPQSPRLAEFLKNTRF

Crispr_ID: NZ_CP014870_8

• CRISPR_ID: NZ_CP014870_8
• CRISPR_location: 2973890-2973980
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_8

Consensus_repeat	Method
GGCAGTGCGCGTTATCGTTCACGT	CRISPRCasFinder

spacers of NZ_CP014870_8

>8.1|2973914|43|NZ_CP014870|CRISPRCasFinder
TTTTCGCGAGCAAGCTCGCTCCTACAGGGGGCGCGTTCTTCCA

CRISPR arrays and Neighbor proteins around NZ_CP014870_8

CRISPR arrays

The CRISPR arrays of NZ_CP014870_8

>merge|NZ_CP014870|8|2973890-2973980|CRISPRCasFinder
GGCAGTGCGCGTTATCGTTCACGTTTTTCGCGAGCAAGCTCGCTCCTACAGGGGGCGCGTTCTTCCAGGCAGTGCGCGTTATCGTTCACGT

>NZ_CP014870|8|7|2973890-2973980|CRISPRCasFinder
GGCAGTGCGCGTTATCGTTCACGT	TTTTCGCGAGCAAGCTCGCTCCTACAGGGGGCGCGTTCTTCCA
GGCAGTGCGCGTTATCGTTCACGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064677593.1|2968679_2968949_+|DUF1652-domain-containing-protein	unknown	unknown	gnl|CDD|311697
NZ_CP014870.1|WP_064677594.1|2969074_2969347_-|DUF2790-domain-containing-protein	unknown	unknown	gnl|CDD|371321
NZ_CP014870.1|WP_064677601.1|2977556_2978462_-|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|380381
NZ_CP014870.1|WP_064677595.1|2969511_2971008_-|xylulokinase	unknown	unknown	gnl|CDD|198375
NZ_CP014870.1|WP_064677590.1|2965603_2966476_-|Ku-protein	unknown	unknown	gnl|CDD|238408
NZ_CP014870.1|WP_064677602.1|2978535_2979831_-|glycosyltransferase-family-4-protein	unknown	unknown	gnl|CDD|379337
NZ_CP014870.1|WP_064677599.1|2974877_2975804_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NZ_CP014870.1|WP_064677607.1|2985450_2986632_+|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl|CDD|223715
NZ_CP014870.1|WP_064677600.1|2975979_2977290_-|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270303
NZ_CP014870.1|WP_064677598.1|2974036_2974867_-|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NZ_CP014870.1|WP_064677596.1|2971193_2972666_-|mannitol-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|223324
NZ_CP014870.1|WP_064677603.1|2979924_2980290_-|response-regulator	unknown	unknown	gnl|CDD|381145
NZ_CP014870.1|WP_064677589.1|2964542_2965442_+|lipid-A-hydroxylase-LpxO	unknown	unknown	gnl|CDD|380241
NZ_CP014870.1|WP_064677606.1|2984863_2985457_+|chemotaxis-protein-CheB	unknown	unknown	gnl|CDD|319752
NZ_CP014870.1|WP_064677592.1|2968307_2968529_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064677591.1|2967075_2968227_+|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl|CDD|369642
NZ_CP014870.1|WP_082930320.1|2966680_2967025_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064677604.1|2980542_2984034_+|response-regulator	unknown	unknown	gnl|CDD|274362
NZ_CP014870.1|WP_064677597.1|2972682_2973786_-|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	unknown	unknown	gnl|CDD|236947
NZ_CP014870.1|WP_064677605.1|2984033_2984867_+|protein-glutamate-O-methyltransferase-CheR	unknown	unknown	gnl|CDD|224271

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064677596.1|2971193_2972666_-|mannitol-dehydrogenase-family-protein	gnl|CDD|223324	COG0246, MtlD, Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism].	0
NZ_CP014870.1|WP_064677593.1|2968679_2968949_+|DUF1652-domain-containing-protein	gnl|CDD|311697	pfam07865, DUF1652, Protein of unknown function (DUF1652). This is a family containing hypothetical bacterial proteins.	9.10002e-20
NZ_CP014870.1|WP_064677594.1|2969074_2969347_-|DUF2790-domain-containing-protein	gnl|CDD|371321	pfam10976, DUF2790, Protein of unknown function (DUF2790). This family of proteins with unknown function appear to be restricted to Pseudomonadaceae.	2.93797e-21
NZ_CP014870.1|WP_064677601.1|2977556_2978462_-|AraC-family-transcriptional-regulator	gnl|CDD|380381	cd06976, cupin_MtlR-like_N, AraC/XylS family transcriptional regulators similar to MtlR, N-terminal cupin domain. MtlR is a Pseudomonas fluorescens protein that acts as a transcriptional regulator of the mannitol utilization genes. It has an N-terminal cupin domain (represented by this alignment) and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	2.69465e-37
NZ_CP014870.1|WP_064677595.1|2969511_2971008_-|xylulokinase	gnl|CDD|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	0
NZ_CP014870.1|WP_064677590.1|2965603_2966476_-|Ku-protein	gnl|CDD|238408	cd00789, KU_like, Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku homologs are predicted to form homodimers. It is proposed that the Ku homologs are functionally associated with ATP-dependent DNA ligase and the eukaryotic-type primase, probably as components of a double-strand break repair system.	9.80078e-118
NZ_CP014870.1|WP_064677602.1|2978535_2979831_-|glycosyltransferase-family-4-protein	gnl|CDD|379337	pfam13692, Glyco_trans_1_4, Glycosyl transferases group 1.	1.09601e-15
NZ_CP014870.1|WP_064677599.1|2974877_2975804_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.08494e-68
NZ_CP014870.1|WP_064677607.1|2985450_2986632_+|hybrid-sensor-histidine-kinase/response-regulator	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.11275e-46
NZ_CP014870.1|WP_064677604.1|2980542_2984034_+|response-regulator	gnl|CDD|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	1.21905e-67
NZ_CP014870.1|WP_064677598.1|2974036_2974867_-|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.55458e-72
NZ_CP014870.1|WP_064677600.1|2975979_2977290_-|sugar-ABC-transporter-substrate-binding-protein	gnl|CDD|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.94451e-75
NZ_CP014870.1|WP_064677603.1|2979924_2980290_-|response-regulator	gnl|CDD|381145	cd18161, REC_hyHK_blue-like, phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase. Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	4.36998e-22
NZ_CP014870.1|WP_064677589.1|2964542_2965442_+|lipid-A-hydroxylase-LpxO	gnl|CDD|380241	NF033391, lipid_A_LpxO, lipid A hydroxylase LpxO. Members of this family are LpxO, an enzyme that modifies one of the lipid chains in lipid A by hydroxylation, with resulting changes in resistance to the host immune response and to the antibiotic colistin. This family, as built, includes LpxO1 from Pseudomonas aeruginosa, but not its paralog LpxO2.	0
NZ_CP014870.1|WP_064677606.1|2984863_2985457_+|chemotaxis-protein-CheB	gnl|CDD|319752	cd16433, CheB, Chemotaxis response regulator protein-glutamate methylesterase, CheB. This family contains the methylesterase CheB (EC 3.1.1.61; also known as CheB methylesterase, chemotaxis-specific methylesterase, methyl-accepting chemotaxis protein methyl-esterase, or protein methyl-esterase) domain, a phosphorylation-activated response regulator involved in reversible modification of bacterial chemotaxis receptors. Signaling output of the chemotaxis receptors is modulated by CheB and methyltransferase CheR by controlling the level of receptor methylation. cheR and cheB have a strong preference to occur in the same operon, and a subgroup contains multidomain proteins with CheB-CheR fusions. Reversible methylation of transmembrane chemoreceptors plays an important role in ligand-dependent signaling and cellular adaptation in bacterial chemotaxis. Phosphorylated CheB catalyzes deamidation of specific glutamine residues in the cytoplasmic region of the chemoreceptors and demethylation of specific methyl glutamate residues introduced into the chemoreceptors by CheR.	5.40416e-90
NZ_CP014870.1|WP_064677605.1|2984033_2984867_+|protein-glutamate-O-methyltransferase-CheR	gnl|CDD|224271	COG1352, CheR, Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms].	9.13929e-57
NZ_CP014870.1|WP_064677591.1|2967075_2968227_+|PQQ-dependent-sugar-dehydrogenase	gnl|CDD|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	0
NZ_CP014870.1|WP_064677597.1|2972682_2973786_-|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	gnl|CDD|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	0

Protein sequences

>NZ_CP014870.1|WP_064677597.1|2972682_2973786_-|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC
MANLKIKNLQKGFEGFSIIKGIDLEVRDKEFVVFVGPSGCGKSTLLRLIAGLEEVSGGTIELDGRDITEVSPAKRDLAMVFQTYALYPHMSVRKNMSFALDLAGVPKAEVEKKVNDAARILELGPMLERKPKQLSGGQRQRVAIGRAIVRNPKIFLFDEPLSNLDAALRVQMRLELSRLHKELQATMIYVTHDQVEAMTLADKVVVLNGGRVEQVGSPLELYHQPANLFVAGFLGTPKMGFLKGKVTRVERHGCEVLLDAGTRITLPFTGATLNVGGAVTLGIRPEHLELAQPGDCSLQVTADVSERLGSDTFCHVVTASGEALTLRVRGDLASRYGETLSLHLDAGHCHLFDADGVALTRPLRVAA
>NZ_CP014870.1|WP_064677596.1|2971193_2972666_-|mannitol-dehydrogenase-family-protein
MKLNKQNLHHLASEVRLPAYTLSDTRQGIAHIGVGGFHRAHQAYYTDALMNTGKDLDWAICGVGLRAEDRRARDDLKAQDYLFTLLELGDTDDTEVRVIGAIRDMLLAEDGAQALIDKLASPEIRIVSLTITEGGYCIDDSNGEFMAHLPQIQHDLAHPDAPTTVLGFLCAALVKRRAAGTRAFTLMSCDNLPHNGAVTRKALLAFAALRDAELRDWIDSNVSFPNAMVDRITPMTSTGHRLQLADRHAVDDAWPVVCEPFAQWVLEDKFVNGRPAWEQVGVQFTDDVTPYEDMKIKLLNGSHLALTYLGFLKGYRFVHETMNDPLFVRYMRAYMDLDVTPQLSPVPGIDLADYKNTLVERFSNQAIADQLERVCSDGSSKFPKFTVPTINGLIAADCETKRAALVVAAWALYLKGVDEQGDTYSIPDPRAAFCQALVADDALITQRLLAVEEIFGAAIPNSPEFVAAFEWCCNSLREVGVTKTLERVLA
>NZ_CP014870.1|WP_064677595.1|2969511_2971008_-|xylulokinase
MANQQLFLGIDCGTQGTKALILDAHSGEVLGQGAAAHSLISGANGRREQDPAQWLEAFTCATRQALLAAGVDGLDILGIGVSGQQHGLVLLDDKGQVLRAAKLWCDTESTAQNDCLLTHLGGEEGSLERLGVVIAPGYTVSKLLWTKEQHPEVFSRIARILLPHDYLNYWLTGRSCSEYGDASGTGYFNVRTRQWDLQLLRDIDPSGRLQAALPELIDAHQAVGTVLPHIAEHLGINPLALVSSGGGDNMMGAIGTGNIKPGAITMSLGSSGTVYAYADQPKVSPDASVATFCSSSGGWLPLICTMNLTNATGVIRELFELDIERFNELVALAPIGAEGVCMLPFLNGERVPALPHATGSLLGLTMTNLTQANLCRAVVEGTTYGLRYGLDVLRRNGLQSHSICLIGGGSKSAVWRQIVADIMNTPVICTGQSEAAALGAAIQAAWCTSWANGHEHSLADVCERCVKLDPASETLPIAGNVAASQLAYERYRRQVATL
>NZ_CP014870.1|WP_064677594.1|2969074_2969347_-|DUF2790-domain-containing-protein
MNTRTLLSTVALACTAFAGLAQAADTSSTQTQVPAYHYGMPLHIAKVISLTEPTTLYCEVITAEMKYIDTSGQPAQITYRKLSDACSMQS
>NZ_CP014870.1|WP_064677593.1|2968679_2968949_+|DUF1652-domain-containing-protein
MFLSALELRNIIESSFLPKRCQCTLTPELSMTIKVYSDRETDHLDLIKTGIDAKHLNGCREINELITELREDMQKRADVQPLHPDRKAL
>NZ_CP014870.1|WP_064677592.1|2968307_2968529_-|hypothetical-protein
MASYSIKHAANFAVQLIGKFNELAALSAGLFMQNAIKADGDPAICKIHGIKFVTTLIQYLPTPPTRKTKKRVL
>NZ_CP014870.1|WP_064677591.1|2967075_2968227_+|PQQ-dependent-sugar-dehydrogenase
MLRKTFLATLCASTLITAIAPVYAAPIQELKSEQGTLEVTPIVEGLDHPWALAFLPDRQGMLVTERPGNLRLVSADGKLSAPLDGVPKVWAKGQGGLLDVVLSPDFKQDRTVYLSYAEGGGKGDKAGTAVGRGQLSQDLKTINNFKVIFRQEPKLSVGNHFGSRLVFDRDGYLFITLGENNDRPTAQDLDKLQGKVVRIYPDGKVPDDNPFVGQTGVRPEIWSYGQRNPQGAALNPWTGVLWENEHGPRGGDEINIIERGKNYGWPLATHGINYSGQPIPEATGKTAEGTVAPHHVWEKSPGLSGMAFYDADRFQAWQHNVFIGALVTQELIRLQFDGDKVVHEERLMGELNKRIRDVRQGPDGYLYVLTDEDDGVLYKVGLK
>NZ_CP014870.1|WP_082930320.1|2966680_2967025_+|hypothetical-protein
MNRLMLGIAALALSGVLSHPAQADASSLRLAQSPTGHSGNPYNSPIRRANPNSMQGTQPGAPIIRGPNTVPVPRPPTLDNGGIGNRYPQDRTVPSSPPTFIPNPPHRDAGTSNR
>NZ_CP014870.1|WP_064677590.1|2965603_2966476_-|Ku-protein
MARAIWKGAISFGLVHIPVALVSATSSQGVDFDWLDSRSMEPVGYKRVNKVTGKEVTKEHIVKGVQYEKGRYVVLSEEEIKSAHPLSTQTIDIFSFVDSDQIPLQNIDTPYYLAPDKRGGKVYALLRETLSKTNKVALAHVVLHTRQHLAALMPLESAMVLVMLRWPAEVRSLETLELGSDVTSAKLVKGELDMAKRLVEDMSAEWSPEDYRDSFEDKIMALVEKKAHEGKIEDVETATGEEERKTADVIDLTELLKRSLGGKAAAKPAAKAKSSDKPAPAKKTSKRSSG
>NZ_CP014870.1|WP_064677589.1|2964542_2965442_+|lipid-A-hydroxylase-LpxO
MKLIIAVIYVVSIAYVHLRGRVRHKLGRQLSDHSTFLAPVNCVLYLFSKTPDRPYLDTADFPDLSPLQTHWQDIRAEGLHLLRAGEIKRSSQYDDVGFNSFFKTGWKRFYLKWYGDSHPSAMKLCPRTTELVQSIGSIKAAMFAELPPGARLVRHRDPYAGSYRYHLGLDTPNDAGCYINVDGESYHWRDGEAVIFDETFIHYAENTTDQNRIILFCDIERPMKYRWAAAFNRWFSRTVMAAAGSPNDVGDKTGGINRLFGKIYKFRLRAKALKKRNRKLYYLEKWAILGGLLAVFVLI
>NZ_CP014870.1|WP_064677598.1|2974036_2974867_-|carbohydrate-ABC-transporter-permease
MTLQHSRRLQSLLLGTLAWAIAILIFFPIFWMVLTSFKSEIDAFATPPQFIFTPTLENYLHINERSDYVSFAWNSVVISFSATALCLLIAVPAAYSMAFYETQRTKGTLLWMLSTKMLPPVGVLMPIYLLAKSFGLLDTRIALIVIYTLINLPIVVWMIYTYFKDIPRDILEAARLDGAKLWQEMVRVLLPIAKGGLASTVLLSLILCWNEAFWSLNLTSSQAAPLTALIASYSSPEGLFWAKLSAVSTLACAPILIFGWISQKQLVRGLSFGAVK
>NZ_CP014870.1|WP_064677599.1|2974877_2975804_-|sugar-ABC-transporter-permease
MNISTAKAHIDLPQPLRKSRLANPGWFLVSPSVALLLLWMIVPLGMTVYFSLIRYNLLYPGENQFVGLENFSYFLSDSGFMPGATNTLLLVGSVLLISVVFGVLISALLEASEFLGRGLVRVLLISPFFIMPTVGALIWKNLIFHPVSGILAYVWKLFGAQPVDWLAHYPLLSIIIIVSWQWLPFAILILMTAMQSLDQEQKEAARLDGAGPIAIFWHLTLPHLARPIAVVVMIETIFLLSVFAEIFTTTNGGPGYASTNLAYLIYNQALVQFDVGMASAGGLIAVLIANIAAIVLVRMIGKNLTDKA
>NZ_CP014870.1|WP_064677600.1|2975979_2977290_-|sugar-ABC-transporter-substrate-binding-protein
MQPSVNALLALTCMTLSSVSLGAQTLTIATVNNSDMIRMQKLSKTFEAEHPDIKLNWVVLEENVLRQRLTTDIATQGGQFDVLTIGMYEAALWGAKGWLEPMKDLPASYALDDVFPSVRDGLSVKGTLYALPFYAESSITYYRTDLFKNAGLTMPERPTWTQIGEFAGKLTDKDKEQYGICLRGKAGWGENMALISTVANAYGARWFDEQWKPEFTGPEWKNALNFYVDTMKKSGPPGASSNGFNENLALFNSGKCAIWVDASVAGSFVTDKTQSKVSEHVGFTYAPHETTDKGSAWMYSWALAIPTSSKAKDAAKTFSTWATSKEYGALVAEKDGIANVPPGTRASTYSEAYLQAAPFAKVTLESLKAADPSKPSAKPVPYIGIQLVTIPEFQAVGTQVGKLFSAALIGQTTVDQALTAAQSTTEREMKRAGYPK
>NZ_CP014870.1|WP_064677601.1|2977556_2978462_-|AraC-family-transcriptional-regulator
MTRTARVTDPSYELMDDHNGLSIIYRQHGFPCPLVRWHFHKEYELHLIVASSGKVFIGDYIGNFYPESLFLTGPNLPHNWISQVAEDEVVPKRDMLVNFTDELFDSGHLVFAEFKTLIPLLERAQYGIEFRCKRTIRQAMDLMQRIADSTGVTRLGHFFILLELLASCDDYQTLSGATTPQLADEHNIDRTNRAVDYIFAHYARDLPLEEVAEHLGMKPTYFSRVFKQATGRCFIEFVNRLRISKSCELLADGDKPVTDVCFESGFNNISNFNRRFQQLKGMTPSHYRKLAVQRLTEQNLG
>NZ_CP014870.1|WP_064677602.1|2978535_2979831_-|glycosyltransferase-family-4-protein
MSQPRATKVLVIGYVWPEPRSSAAGGHMMQILETFLEQGWDITFSSPAGTGEHRADLAALGIREVPIELNNSSFDSFISQLAPDVVLFDRFMMEEQFGWRVEQQCPDALRVLETSDLQSLRDARHLRLKERLKASDDADDFSELFAKALRAEFEFMAGTDLAKREIAAIYRCDLNLMISDVEIELLVEQFKVPRNLLHGCPLMVDLPSAPPAAFEERAHFLSIGNFRHAPNWDAVLWMKTTLWPLIREQLPSAQLHIYGAYTPPKATALHNAAQGFHVMNWAEDALQVMSAARVCLAPLRFGAGIKGKLVDAMLCGTPNVTTPIGAEAMHGDEPWPGAVTRTAQAFADNAVQLYKDKTRWLDAQAQGLQLLASRYQRTRHGPALIARINECRLHLSSIRRDNFTGSMLRHHQHKSTQYMSQWIEAKNRLIT
>NZ_CP014870.1|WP_064677603.1|2979924_2980290_-|response-regulator
MSPDASIILVVEDDAIVRMLIVDVLEELEFKVLEADGSEQALEFLNDEDQHIDLMMTDVGLPVMDGRELATQARMLRADLPILFASGYAESIEVPDGMQVIGKPFSIEQLRDKVRVMLNNA
>NZ_CP014870.1|WP_064677604.1|2980542_2984034_+|response-regulator
MTSASSVDEQRFRKLLSRNVSLPLGVGVLSAVFFVSLIAYLLSVIQWVEHTDRVINNANESIKLTVDLETGMRGFLLTGDEQFLEPYETAKPRIAVALKTLLDLTADNPVQTDRLHRLQALQDEWAAYATTIIELQRSRGDYRAAVKAGQGKRLTDEIRKQFEDVIDMEQQLRTARNEEVRRTTVWSIVLYMLFIAGISALLAYIGRRDLLNLSQSYSANLAAQQASARRLEQQAWLRNGQTELAEQVLGQLSLNVLGRNILQFCAQYLGTAVAAIYVREEHGGLKRIASYGLSREQEALDQQIHSGEGIVGQVAEQARLIRLDNVPSDYFKVSSGLGEGLPHSVLVVPTSDDDRINGVIELGFLRPLDERDVELLELIAGNIGTSIEAARYRQRLQEVLAETQQLNEELQVQQEELKTANEELEEQSRILKESQAHLETQQVELEQTNEQLADQAQILADQRDAMDLKNTELNQAQIQLEERAEELQRSSKYKSEFLANMSHELRTPLNSSLILAKLLAENPQQNLSAEQVKFAESIYSAGNDLLNLINDILDISKVEAGKLEVRPENTSVARLVEGLRGMFQPLAADKRLDLQVELQPGAPTMIYTDRQRLEQVIKNLLSNAVKFTEKGSVSLTVANQPGDGIAFVVRDSGIGIAADQQDSIFEAFRQADGTTNRRYGGTGLGLSISRDLAALLGGSISVTSEPGQGSVFTLVLPRQYVEPGDEPVEPMKASPVAMTPRVTPAAPVPLIAAVDIPRFDDDRAKAPFTTRCILVVEDEPNFAHILYDLAHELGYQCLVAHGADEGYDLAREFIPDAILLDMRLPDHSGLTVLQRLKEHAQTRHIPVHVISVEDRVEAAMHMGAIGYAVKPTTREELKDVFARLEAKLTQKVKRVLLVEDDDVQRDSIARLIGDDDIEITAVGLAQEALNLLRTTVFDCMIIDLKLPDMLGNDLLKRMSTEDICSFPPVIVYTGRNLTRDEEAELRKYSRSIIIKGARSPERLLDEVTLFLHKVESGLSHERQRMLKTARSRDKVFEGRKVLLVDDDVRNIFALTSALEHKGAVVVIGRNGREAIERLNEIEDIDLVLMDVMMPEMDGFEATSLIRKDPRWRKLPIIAVTAKAMKDDQERCLQAGSNDYLAKPIDLDRLFSLIRVWLPKMERI
>NZ_CP014870.1|WP_064677605.1|2984033_2984867_+|protein-glutamate-O-methyltransferase-CheR
MESIYSGERNSEIELRLLIEAIYLKYSYDFRDYSGASIKRRVHHALTQFECATISALQEKVLHDPTAFMQLLQLLTIPVSEMFRDPSHFLAIRQEVVPLLKTYPSIKIWIAGCSTGEEVYSMAILLREEGLLDRTIIYATDINPRSLDKAKQGIFSMENVRAYTHNYQQAGGQQSFADYYTAAYGYAIFDKTLCDNVTFADHSLATDSVFSETQLISCRNVLIYFNKKLQDRAFGLFHESLCHRGFLVLGSKETPDFSAYGNQFDPLIKQERIYRKS
>NZ_CP014870.1|WP_064677606.1|2984863_2985457_+|chemotaxis-protein-CheB
MNRAKELPCMEAIVIGASAGGVQALLTLLGPLRKGFVLPIIVVLHLPEAGRSQLAEVFARRVALPVLEARDKTPIQAGTLYFAGPGYHLSVEQDRSFSLSLEDRVHYSRPAIDYLFESAADAYGQALAAVLLTGANRDGAHGLAKVKHRGGLTIVQDPDEAQVATMPLAALDTLAPDHILPLRGIGRLLVELERIAC
>NZ_CP014870.1|WP_064677607.1|2985450_2986632_+|hybrid-sensor-histidine-kinase/response-regulator
MLSNIQAKLLIVDDLPENLLALEALIKREDRIVYKALSADEALSLLLQHEFAIAILDVQMPGMNGFELAELMRGTEKTRNIPIVFVSAAGRELNYAFKGYESGAVDFLYKPLDIHAVKSKVNVFVDLFRQSKAMKQQVEALERSRREQAALLEQLQSTQLELEQAVRMRDDFMSIVAHEVRTPLNGLILETQLRKMHLARDNAAAFTLEKMHAMVDRDERQIKSLIRLIEDMLDVSRIRTGKLSIRPTRFDLSALVEDLLQNFAPQIEAAESSVTLQAGHPVVGHWDEFRIEQVISNLLTNALRYGAKSPITVKVYSENGQALVEVQDLGIGIGEENQKRIFQQFERVSAKHAVAGLGLGLFISEQIVTAHGGSITVQSRIGEGALFRVCLPL

Crispr_ID: NZ_CP014870_9

• CRISPR_ID: NZ_CP014870_9
• CRISPR_location: 3078056-3078155
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_9

Consensus_repeat	Method
TCTGTTGTACCGCGTTATCGTTCTTCGCC	CRISPRCasFinder

spacers of NZ_CP014870_9

>9.1|3078085|42|NZ_CP014870|CRISPRCasFinder
TGTAGGAGCGAGGCTTGCCCGCGAACCAGGCGCTGCGGTATA

CRISPR arrays and Neighbor proteins around NZ_CP014870_9

CRISPR arrays

The CRISPR arrays of NZ_CP014870_9

>merge|NZ_CP014870|9|3078056-3078155|CRISPRCasFinder
TCTGTTGTACCGCGTTATCGTTCTTCGCCTGTAGGAGCGAGGCTTGCCCGCGAACCAGGCGCTGCGGTATATCTGTTGTACCGCGTTATCGTTCTTCGCC

>NZ_CP014870|9|8|3078056-3078155|CRISPRCasFinder
TCTGTTGTACCGCGTTATCGTTCTTCGCC	TGTAGGAGCGAGGCTTGCCCGCGAACCAGGCGCTGCGGTATA
TCTGTTGTACCGCGTTATCGTTCTTCGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064677673.1|3074353_3075697_-|sodium:proton-antiporter	unknown	unknown	gnl|CDD|223104
NZ_CP014870.1|WP_064677670.1|3072060_3072300_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_152032260.1|3080826_3083892_+|formate-dehydrogenase-N-subunit-alpha	unknown	unknown	gnl|CDD|273689
NZ_CP014870.1|WP_064680702.1|3073872_3074169_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064677676.1|3077035_3077554_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064677685.1|3086631_3088062_+|L-seryl-tRNA(Sec)-selenium-transferase	unknown	unknown	gnl|CDD|235278
NZ_CP014870.1|WP_064677682.1|3083892_3084828_+|formate-dehydrogenase-subunit-beta	unknown	unknown	gnl|CDD|273705
NZ_CP014870.1|WP_064680703.1|3088058_3089966_+|selenocysteine-specific-translation-elongation-factor	unknown	unknown	gnl|CDD|182508
NZ_CP014870.1|WP_064677674.1|3075743_3076355_-|YIP1-family-protein	unknown	unknown	gnl|CDD|369140
NZ_CP014870.1|WP_064677677.1|3077562_3078003_+|DUF421-domain-containing-protein	unknown	unknown	gnl|CDD|225205
NZ_CP014870.1|WP_064677675.1|3076524_3077046_+|CinA-family-protein	unknown	unknown	gnl|CDD|224463
NZ_CP014870.1|WP_064677683.1|3084824_3085478_+|formate-dehydrogenase-subunit-gamma	unknown	unknown	gnl|CDD|182608
NZ_CP014870.1|WP_064677687.1|3092098_3093277_-|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|180261
NZ_CP014870.1|WP_064677686.1|3090298_3092002_-|class-I-poly(R)-hydroxyalkanoic-acid-synthase	unknown	unknown	gnl|CDD|213656
NZ_CP014870.1|WP_064677684.1|3085482_3086409_+|formate-dehydrogenase-accessory-protein-FdhE	unknown	unknown	gnl|CDD|130625
NZ_CP014870.1|WP_064677672.1|3073098_3073575_-|hemerythrin-domain-containing-protein	unknown	unknown	gnl|CDD|376622
NZ_CP014870.1|WP_064677669.1|3070018_3071941_+|PAS-domain-containing-hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl|CDD|237425
NZ_CP014870.1|WP_064677671.1|3072384_3072921_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064677679.1|3079283_3080438_-|PatB-family-C-S-lyase	unknown	unknown	gnl|CDD|275146
NZ_CP014870.1|WP_064677678.1|3078195_3079053_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187613

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064677673.1|3074353_3075697_-|sodium:proton-antiporter	gnl|CDD|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	2.72955e-43
NZ_CP014870.1|WP_064677687.1|3092098_3093277_-|acetyl-CoA-C-acetyltransferase	gnl|CDD|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0
NZ_CP014870.1|WP_152032260.1|3080826_3083892_+|formate-dehydrogenase-N-subunit-alpha	gnl|CDD|273689	TIGR01553, Formate_dehydrogenase_major_subunit, formate dehydrogenase-N alpha subunit. This model describes a subset of formate dehydrogenase alpha chains found mainly in proteobacteria but also in Aquifex. The alpha chain contains domains for molybdopterin dinucleotide binding and molybdopterin oxidoreductase (pfam01568 and pfam00384, respectively). The holo-enzyme also contains beta and gamma subunits of 32 and 20 kDa. The enzyme catalyzes the oxidation of formate (produced from pyruvate during anaerobic growth) to carbon dioxide with the concomitant release of two electrons and two protons. The electrons are utilized mainly in the nitrate respiration by nitrate reductase. In E. coli and Salmonella, there are two forms of the formate dehydrogenase, one induced by nitrate which is strictly anaerobic (fdn), and one incuced during the transition from aerobic to anaerobic growth (fdo). This subunit is one of only three proteins in E. coli which contain selenocysteine. This model is well-defined, with a large, unpopulated trusted/noise gap. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport].	0
NZ_CP014870.1|WP_064677685.1|3086631_3088062_+|L-seryl-tRNA(Sec)-selenium-transferase	gnl|CDD|235278	PRK04311, PRK04311, selenocysteine synthase; Provisional.	0
NZ_CP014870.1|WP_064677682.1|3083892_3084828_+|formate-dehydrogenase-subunit-beta	gnl|CDD|273705	TIGR01582, Formate_dehydrogenase_iron-sulfur_subunit, formate dehydrogenase, beta subunit, Fe-S containing. This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport].	5.46465e-153
NZ_CP014870.1|WP_064680703.1|3088058_3089966_+|selenocysteine-specific-translation-elongation-factor	gnl|CDD|182508	PRK10512, PRK10512, selenocysteinyl-tRNA-specific translation factor; Provisional.	0
NZ_CP014870.1|WP_064677674.1|3075743_3076355_-|YIP1-family-protein	gnl|CDD|369140	pfam06930, DUF1282, Protein of unknown function (DUF1282). This family consists of several hypothetical proteins of around 200 residues in length. The function of this family is unknown although a number of family members are thought to be putative membrane proteins.	6.66624e-28
NZ_CP014870.1|WP_064677677.1|3077562_3078003_+|DUF421-domain-containing-protein	gnl|CDD|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	1.04729e-36
NZ_CP014870.1|WP_064677675.1|3076524_3077046_+|CinA-family-protein	gnl|CDD|224463	COG1546, CinA, Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only].	3.00295e-48
NZ_CP014870.1|WP_064677683.1|3084824_3085478_+|formate-dehydrogenase-subunit-gamma	gnl|CDD|182608	PRK10639, PRK10639, formate dehydrogenase cytochrome b556 subunit.	5.02419e-75
NZ_CP014870.1|WP_064677686.1|3090298_3092002_-|class-I-poly(R)-hydroxyalkanoic-acid-synthase	gnl|CDD|213656	TIGR01838, Poly-beta-hydroxybutyrate_polymerase, poly(R)-hydroxyalkanoic acid synthase, class I. This model represents the class I subfamily of poly(R)-hydroxyalkanoate synthases, which polymerizes hydroxyacyl-CoAs with three to five carbons in the hydroxyacyl backbone into aliphatic esters termed poly(R)-hydroxyalkanoic acids. These polymers accumulate as carbon and energy storage inclusions in many species and can amount to 90 percent of the dry weight of cell. [Fatty acid and phospholipid metabolism, Biosynthesis].	0
NZ_CP014870.1|WP_064677684.1|3085482_3086409_+|formate-dehydrogenase-accessory-protein-FdhE	gnl|CDD|130625	TIGR01562, Protein_FdhE, formate dehydrogenase accessory protein FdhE. This model describes an accessory protein required for the assembly of formate dehydrogenase of certain proteobacteria although not present in the final complex. The exact nature of the function of FdhE in the assembly of the complex is unknown, but considering the presence of selenocysteine, molybdopterin, iron-sulfur clusters and cytochrome b556, it is likely to have something to do with the insertion of cofactors. The only sequence scoring between trusted and noise is that from Aquifex aeolicus, which shows certain structural differences from the proteobacterial forms in the alignment. However it is notable that A. aeolicus also has a sequence scoring above trusted to the alpha subunit of formate dehydrogenase (TIGR01553).	6.29823e-114
NZ_CP014870.1|WP_064677672.1|3073098_3073575_-|hemerythrin-domain-containing-protein	gnl|CDD|376622	pfam01814, Hemerythrin, Hemerythrin HHE cation binding domain. Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor hemerythrin binds Cadmium so as to protect the organism from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial NorA is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus the iron-sulfur cluster repair protein ScdA has been noted to be important when the organism switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger.	8.70203e-10
NZ_CP014870.1|WP_064677669.1|3070018_3071941_+|PAS-domain-containing-hybrid-sensor-histidine-kinase/response-regulator	gnl|CDD|237425	PRK13557, PRK13557, histidine kinase; Provisional.	2.62471e-112
NZ_CP014870.1|WP_064677679.1|3079283_3080438_-|PatB-family-C-S-lyase	gnl|CDD|275146	TIGR04350, aminotransferase_class_I_and_II, putative C-S lyase. Members of this subfamily are probable C-S lyases from a family of pyridoxal phosphate-dependent enzymes that tend to be (mis)annotated as probable aminotransferases. One member is PatB of Bacillus subtilis, a proven C-S-lyase. Another is the virulence factor cystalysin from Treponema denticola, whose hemolysin activity may stem from H2S production. Members of the seed alignment occur next to examples of the enzyme 5-histidylcysteine sulfoxide synthase, from ovothiol A biosynthesis, and would be expected to perform a C-S cleavage of 5-histidylcysteine sulfoxide to leave 1-methyl-4-mercaptohistidine (ovothiol A).	9.83515e-147
NZ_CP014870.1|WP_064677678.1|3078195_3079053_-|SDR-family-oxidoreductase	gnl|CDD|187613	cd05355, SDR_c1, classical (c) SDR, subgroup 1. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.18811e-150

Protein sequences

>NZ_CP014870.1|WP_064677677.1|3077562_3078003_+|DUF421-domain-containing-protein
MDSVLRATVMYLALMVLFKIAGRRSLAELTTFDFVLLMIIGEATQQALLGDDFSMTNSMLVIVTLIAIDVGLSLLKQRSQWVSQLIDGGPTIIVENGKLLHKRLRHARLIEADVMEAARSSQGIETLDQIKFAILERNGKISVIAM
>NZ_CP014870.1|WP_064677676.1|3077035_3077554_+|hypothetical-protein
MNDESGHTDYRNRDYPVREDMAYQVKVWRFERWGWYTLVLLVVLALLGLFSRGPLSTRDVQGGDGKVRVQYELFHRNGSTNPMQLSVIGTPDAMVELELSGAMLDGFSIESLQPEPIRAVSAGEGMKLWVQTDAQGRANLHLTLRGDGLGLFHSRIASPGATAVDFDQFIFP
>NZ_CP014870.1|WP_064677675.1|3076524_3077046_+|CinA-family-protein
MNVSQSVVEYLRQNDLLLSTAESCTAGKIITLLAEVPHSGELIESGYVVYSPEAKQRLLNVSPETIETFNLTSCEVAREMASGALRDSTANVAVATTGILGPEDVDGIPAGTICFAWAFQTPQGRRVFSQQSRFFGTRSEVQLLAAEHALKLLPHFHQRALAGEQDPGALDER
>NZ_CP014870.1|WP_064677674.1|3075743_3076355_-|YIP1-family-protein
MSAPIVKLFTQPNFAWTDIRKEEEAHPRHYLAHLLLLALIPPVCLFIGTTYVGWSLAENEIVKLSAGSALQLCGLLYVTIVAGVALMGLFIRWMSRTFDSRPTVNQCIGFAAYTVTPFFLAGIAGLYPSRWLAIAVLGAASLYSTFLLFVGLPTFMHERKEQGLLNAACVWGVGLLVLVTILVEMILIWFNLLTPEYLRATVG
>NZ_CP014870.1|WP_064677673.1|3074353_3075697_-|sodium:proton-antiporter
MSFIVWVAVLGAVLLTLALTSSYLRWMPVTTSAVCLVLGVVIGPAGLGLLKLDTTDASIWMEHLTEVAVLFSLFVCGLKLRSPLREKNWRIAFGLAGPVMLLTIAGVCLLLHYAFQLPWGASVLIGSILAPTDPVLASLVQVNDARDDDRVRFGLSGEAGLNDGIAFPFVILGLLLVQHDGNPGWLGDWVLRSVLWAVPAGLLTGYWMGRGIGRVTLSLRIHNDDSTLSPNDYLALALIALSYVVAESIHGYGFLSVFAAGLGLRQEEVKSTGTDELPAEHLVQPVVGHQNVEPQHAVHGDTALLEDTQVAAGIMMSDMLAFGGLVERAMEVFLVTLLGVVLVAHWDWRALAIAGGLFCLIRPLSVVAMPWGGLLDMRQRLLIGWFGIRGIGSLFYLFYALNHGLAPSIATLCIDLTLSVVALSILVHGISTQPILARYERRKKQDI
>NZ_CP014870.1|WP_064680702.1|3073872_3074169_-|hypothetical-protein
MIHYSTCEEIKACRAFALERNRQMFAEAQALSRSAFELLEDSEMDGELFDRYLDIRRKANLKFQEAIEHLRVLNADFPPVSPSTQNAQRLHREAESRV
>NZ_CP014870.1|WP_064677672.1|3073098_3073575_-|hemerythrin-domain-containing-protein
MNAIDLLKADHERVKGILTQLSESTERGIKKRGELLAKLEMEITIHTRLEEEVLYPAYKKAGGKEQDVMYYEAKEEHRTVDSLVLPDLKVTDPSTPEFAGRVKVVKELLEHHIEEEETEMFPQAKKLLGKATLEELGAQMETLKAQYKKEMSAGNMAA
>NZ_CP014870.1|WP_064677671.1|3072384_3072921_+|hypothetical-protein
MPRILTEAPAEETLTEHNAKMFGSPKERLDFYRREIQYETSILANRTDAYLAAQSFLLIAFASCMSNLNPEWGKLFTLVVPPFLALLGVLSSLNAWPGIRAAYDIIDHWHFKQSELLRSEPLMGLAYDESPLFSEMESSHKGYRKSLLFSVRTPWIFATFWVLLGTYAVYIQVTNPGG
>NZ_CP014870.1|WP_064677670.1|3072060_3072300_-|hypothetical-protein
MDYLDWVQWPAMLVTVLAAWLIGSQNPERRVSGFICFIVSNVLWVIWGYHTQAYALIVLQFCLCAMNLRGFRKNAHSTT
>NZ_CP014870.1|WP_064677669.1|3070018_3071941_+|PAS-domain-containing-hybrid-sensor-histidine-kinase/response-regulator
MSEDRSKATSIDDSRFRLLIDAVIDYAIYMIDPDGIITSWNAGARRFKGYEEAEILGQHFSRFYTEEDRRAGMPQRALNTAITEGRFEGEGWRVRKDGTHFWCHVVIDPIIDPSGTLLGFAKITRDLTDRKMAEETLKQSEQQFRLLVQSVTDYAIYMLAPDGRLTNWNLGAQRIKGYLPAEVIGQHFSMFYTPEDREAGEPQRTLSIAIRDGRFENKGWRVRKDGTRFLAHVVVDPIWGDTGTLLGFAKITRDITEVTQAQQVLEQTREALFQAQKMQAIGQLTGGIAHDFNNLLTVILGNLEIVRKRLGDDPRITRLVDNATQGAMRGVSLTQRMLAFARRQELKAEPVEIPTLVQGISGLLRSSLGPSVVLETHFSPELEPVLADINQLELAVLNLATNARDAMPHGGKMVISARTVEVCDQLQFTPMSGRYVCLSISDTGEGMDEATLALAMDPFFTTKGVGKGTGLGLSMVHGFIEQLGGRFILKSQIDKGTTAELWIPVATTGSVAMPATEEDTATTVPRLCVLVVDDDSLVLTSTSLLLEDLGHRVVSAVSGAMALKAIEVEPAIDLVITDMAMPQMNGAQLAQAIRTLKPDLPIILATGYAERLEGFAMELPRLSKPYTQLNLVEIIASTMK
>NZ_CP014870.1|WP_064677678.1|3078195_3079053_-|SDR-family-oxidoreductase
MNDYPKPPFPKQGQPVPGSQKKMDPYPDCGEQSYKGSGRLEGKIALITGADSGIGRAVAIAFAREGADVVVAYLNEHEDAQETARWVEQAGRQCLLLPGDLAQKEQCQALVDKTVERFGRIDVLVNNAAFQMTHENFEDIPDDEWVMTFDVNITAIFRICQAALKHMQPGSSIINTSSVNSDMPKPTLLPYATTKGAIANFTAGLAQMLGEKNIRVNCVAPGPIWTPLIVSTMPDEEVQNFGGQTPLGRPGQPVEVAPIYVLLASDEASYITGQRYGITGGKPML
>NZ_CP014870.1|WP_064677679.1|3079283_3080438_-|PatB-family-C-S-lyase
MTFDFDQVFDRHGTGSTKWSRYPADVLPMWVADMDFAAPPVIIQALQKRLEHPLLGYSVAQDDLRNAIVADLWKKYAWRVEPQELIFLPGVESGFNMALHALVQPQQNVVVQTPNYPPLRHAPGHWGLNKVELGFDALPDGTYATPLQALRQSLEGGGALLLSNPHNPLGKVFPREELQAVANICLEQDAWIISDEIHAELCFDGRVHLPIATLSPEIARRTITLMSASKAYNIAGLKTSFMIIQDKAVRERVNHARCGLVDSVNPLGLEATRIAYSEAGPWLAGLMVYLQGNRDYLVDAVRTRLPGVTMNVPQSTYLAWLDCSALGLDNPQQFFLEQAKVGLSAGLDFGDDGQQFVRLNFGCPRALLEEGIARMERSLRNRKA
>NZ_CP014870.1|WP_152032260.1|3080826_3083892_+|formate-dehydrogenase-N-subunit-alpha
MDLNRRQFFKVAGIGLAGSSLGALGMAPATAFAEQVRHFKLAHTHETRNTCPYCSVGCGLIMYSQGDAAKNVAQNIIHIEGDADHPVNRGTLCPKGAGLLDFIHSPGRLQYPEVRKPGSSEWTRVSWDEALDRVADLMKADRDANFVEKNDEGKTVNRWLTTGFLAASAASNEAGYITHKVIRSLGMLGFDNQARVUHGPTVASLAPTFGRGAMTNTWTDIANANLILVMGGNAAEAHPCGFKWVTEAKAHNAARLIVIDPRFTRTASVADYYAPIRTGTDIAFMGGLINYLLTEDKIQHEYVRNYTDLSFLVDPGFTFEDGIFSGYDAAKRRYTDKTTWNYQYAADGFAMVDPTLQDPRCVYQLLKQHYSRYNLELVSQICGMPTESIQKIWEEIATCSAPGKTMTILYALGWTQHSIGSQIIRSAAMVQLLLGNVGMPGGGVNALRGHSNIQGLTDLGLLSNTLTGYLTLPSDSEQDYDTYIFKRALKPLRPGQMSYWQNYGKFHVSLMKSWYGANATADNHWGYDYLPKIDVPSYDILKMFDMMGQGKVNGYMCQGFNPIAALPDKNRVTAALAKLKWLVIMDPLATETSEFWKNVGPYNDVKSADIQTEVIRLPTTCFAEEDGSLVNSSRWLQWHWKGADGPGLARTDIRIMSELFLRLRQRYQANGGAYAEPMMKLSWPYKVPEEPSPEELAREINGSATADFTDATGATIKAGAQLAGFGQLKDDGSTASGCWIFCGSWTEAGNQMARRDNSDPYGTHQHQGWAWAWPANRRILYNRASCDPQGKPWAENKRLVWWNGKTWAGTDIPDYKADSPPEAGMNPFIMAPEGVGRFFTRDNMAEGPFPEHYEPFETPIGINPLHPNNKGATSNPAARIFDSVWDTLGVAKDYPYAATSYRLTEHFHFWSKHCKLNAITQPEQFVEIGEVLAKEKGIVAGDKVRVSSRRGFIEAVAVVTKRIRPLQVNGQVVHHIGIPLHWGFTGLTRHGYLTNTLVPFLGDGNSQTPESKSFLVNVEKV
>NZ_CP014870.1|WP_064677682.1|3083892_3084828_+|formate-dehydrogenase-subunit-beta
MASQDIIARSATTTVSPSVRIQDEVAKLIDTTKCIGCKACQVACSEWNELRDDVGHNLGTYDNPHDLSADTWTLMRFTEHETDAGNLEWLIRKDGCMHCAEPGCLAACPSPGAIIKHANGIVDFDQDHCIGCGYCITGCPFNIPRISQKDHKAYKCTLCSDRVAVGLEPACVKTCPTGAIVFGTKEDMKEHAAERIVDLKSRGFENAGLYDPAGVGGTHVMYVLHHADTPVLYAGLPDHPTISPLVDLWKGVSKPLGLLAMGLAVLAGFFHYVRVGPQLVEEDELPGVVDPAVHEVDPSVHTFDPRGEDRS
>NZ_CP014870.1|WP_064677683.1|3084824_3085478_+|formate-dehydrogenase-subunit-gamma
MIRRQILRYTANQRTNHWLVAIFFFLAALSGLALFHPALFWLSHLFGGGPWTRILHPFMGVVMFVLFLGLVLQFFRANFFITNDRLWLRRVGPVMRNEEEGVPAIGKYNPGQKLLFWTLLLCMLVLLFSGLVIWRAYFSQYFGITAIRWAMLLHAVAGLILVLSIIVHIYAGIWIKGSVSAMTHGWVSRAWAKKHHELWYREVTRDEHPERPVNRKG
>NZ_CP014870.1|WP_064677684.1|3085482_3086409_+|formate-dehydrogenase-accessory-protein-FdhE
MATILEPGDIEAAASSPPFLHLPPNNLFTLRAQRLERLADGHPLADYLRLVAGLCHVQQQLMDDPPATAPTDPERLRVCQQHGLPPFAADSLVREGVWLPFLDALLQRYPPPARPAVEKALASLRNANVGQLKAWAVALVSGQFTLLPAALVPFLGAALQAAWSHWLLGTPNLHLKPGDSLSQCPACGSPAMAGVIRHRGKYNGLRYLVCSLCACEWHVVRVKCVYCEQSKGLEYLSLDDDRHAADQAPLRAETCPGCHSYLKLLYLENDAEAEALSTDLSSLMLDMRLEQEGYQRPAPNLLLAPGGD
>NZ_CP014870.1|WP_064677685.1|3086631_3088062_+|L-seryl-tRNA(Sec)-selenium-transferase
MPSRSASQTLRLPSIDSLLRHPACQPLAQRYGRDALLASLRQLLDDLREAVHDGAVEGVEITPQVLAGRVGERLAIQHRSHVRRVFNLTGTVLHTNLGRALLPEEAIDAVQLAARYPLNLEFDLHSGKRGDRDDLIEGLVRELTGAEAVTVVNNNAAAVLLTLNSLGARKEGIISRGELIEIGGAFRIPDIMARAGVKLHEVGTTNRTYARDYEAAIGPRSGLVMRVHASNYAIEGFTARVPTAELAQLAHRHGLPLLEDLGSGSLLDLTRWGLPAEPTVRQALLDGADIVTFSGDKLLGGPQAGLIVGRKDLIARIKKNPLKRALRVDKLTLAALEAVLGLYRDPDRLAERLPTLRLLTRPQADILAQAERLQPALARVLGDGWSVGAVTALGMIGSGSQPVARLPSAALCIRPDTSKRLRGRRLHGLETALRGLPIPVLGRIDDDALWLDLRQLDDEAAWLAQLEQWPREGAST
>NZ_CP014870.1|WP_064680703.1|3088058_3089966_+|selenocysteine-specific-translation-elongation-factor
MIVGTAGHIDHGKTALLQALTGQAGDRRREERERGMTIDLGYLYAALEPGAALTGFIDVPGHERFTHNMLAGAQGIDLVLLVVAADDGVMPQTREHLAIVELLGIPRALIAITKCDRVDPARVQAVDEQIEALLVPGPYAGAPRIALSSVTGAGVETLRQALLQAQHEVLQRNTHGGFRLAIDRAFSVAGAGIVVTGTALSGQVAVGDTLMLGPQGKPVRVRGLHAQNQAAASACAGQRVALNLSAERLALEQIRRGHWLLAEWLYAPTQRLDIELRLLAGEDRPLEHFQSVHVHLATHDVMGRVALLEGTSLVPGGQMLAQLLLNAPVQAVRGDPLILRDQSAQRTLGGGPVLDPFAPNRHRRSPERLAQLQALASSQSLEQVLPVLLANSDTGLDPQRLERQFNRPRDSWTLPGDVRLVDTRQGSLLFSATRWEALKISVLEHLARFHRLEPDQMGPDRDRLRRFTGTVLNRPTFISLLEALLASGEMVASGPWLHLPGHQARLSEEDEALWQQLQPVFEQAGYDPPWVRDLGHDPVAVRLLLRKMARLGMLHQVVPDLFYTDAMLRRLAAMLVQLAAENPPIQVTAFRDKVGLGRKRSIQILEYFDRIGLTRRFGDKRHLRLDNALAQPNEP
>NZ_CP014870.1|WP_064677686.1|3090298_3092002_-|class-I-poly(R)-hydroxyalkanoic-acid-synthase
MDNNAHTFNTFWSGQVPFAASFAVQQLRLWVATNPWFTGQDHDAWFDVPRSTLDSLQSDYHQQWAELGQRLLTGQAFTFDDRRFASGNWSQPLFGSLAAFYLLNASFLLKLVDLLPINDKKPRQRLLYLVEQAIAAAAPSNFLASNPDALQRLVDTQGSSLVTGLMHLAADLQEGKMRQCDAAAFKVGVDLANTPGEVVFENELFQLLQYYPQSETQYRRPVFIVPPAINKYYILDLRPDNSMVRHLLQQGHPVFLMSWRNFDQAHAGTTWDDLVETGIIKGLQVTREISGEQRPNCVGFCIGGTLLGSALAVLAARGDKDIASVSLLTTFLDYLDTGPIDIFVDEQLVAYRERTIGGVNGPIGVFKGEDMGNTFSLLRPNDLWWNYNVDKYLKGQKPIPLDLLFWNNDSTNLPGPMYCWYLRHTYLQNDLKSGDLDCCGVKLDLRAIDAPAYILATHDDHIVPWRSAYASTDLLSGTKRFVLGASGHIAGVINPPAKEKRHYWTNDQVNQDPESWFSNAKQHPGSWWNDWFVWLADQAGERQPAVSHAGNEQYPPLEPAPGSYVKQ
>NZ_CP014870.1|WP_064677687.1|3092098_3093277_-|acetyl-CoA-C-acetyltransferase
MNEVVIVAATRTAIGSFQGSLSAIPATELGAAVIRRLLEQTGVDAAQVDEVILGQVLTAGSGQNPARQSAIKAGLPHTVPALTLNKVCGSGLKAVQLAVQAIRCGDAELVIAGGQENMSLAPYVLPKARTGLRMGHAQLQDSVIQDGLWDAFNDYHMGITAENLASKYELSREDQDTFAAASQQKASAAIEGGFFKAEITPILIPQRKGDPLVFDTDEQPRPGSTLQALGNLKPAFQKTGTVTAGNASTLNDGAAVLMLASAAKAQALGLPVLARIKAYASAGVDPSIMGIGPVPATRLALTKAGWSLDDLDLIEANEAFAAQSLAVGKELGWDMNKVNVNGGAIALGHPIGASGARILVSLVHELIRRDGKKGLATLCIGGGQGVSLAIER

Crispr_ID: NZ_CP014870_10

• CRISPR_ID: NZ_CP014870_10
• CRISPR_location: 3317926-3318049
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_10

Consensus_repeat	Method
CCCACAGTTGAAATGCATTCCCCTGTGGGAGCGAG	CRISPRCasFinder

spacers of NZ_CP014870_10

>10.1|3317961|54|NZ_CP014870|CRISPRCasFinder
ACCGGCTTGCCGGCGAAGGGCGGCGACTCGGTACATCGGCGATCCACACAAGCG

CRISPR arrays and Neighbor proteins around NZ_CP014870_10

CRISPR arrays

The CRISPR arrays of NZ_CP014870_10

>merge|NZ_CP014870|10|3317926-3318049|CRISPRCasFinder
CCCACAGTTGAAATGCATTCCCCTGTGGGAGCGAGACCGGCTTGCCGGCGAAGGGCGGCGACTCGGTACATCGGCGATCCACACAAGCGCCCACAGTTGAAATGCATTCCCCTGTGGGAGCGAG

>NZ_CP014870|10|9|3317926-3318049|CRISPRCasFinder
CCCACAGTTGAAATGCATTCCCCTGTGGGAGCGAG	ACCGGCTTGCCGGCGAAGGGCGGCGACTCGGTACATCGGCGATCCACACAAGCG
CCCACAGTTGAAATGCATTCCCCTGTGGGAGCGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064677852.1|3314247_3315012_+|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224051
NZ_CP014870.1|WP_064680713.1|3306975_3308049_-|tryptophan-7-halogenase	unknown	unknown	gnl|CDD|223717
NZ_CP014870.1|WP_064677853.1|3315065_3315890_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270225
NZ_CP014870.1|WP_064677855.1|3316943_3317831_+|polysaccharide-deacetylase	unknown	unknown	gnl|CDD|200563
NZ_CP014870.1|WP_064677864.1|3329729_3331073_-|CDP-diacylglycerol--serine-O-phosphatidyltransferase	unknown	unknown	gnl|CDD|236510
NZ_CP014870.1|WP_064677860.1|3324794_3325988_-|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl|CDD|180775
NZ_CP014870.1|WP_046047004.1|3313358_3314237_+|amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|223836
NZ_CP014870.1|WP_064677851.1|3311777_3313205_+|argininosuccinate-lyase	unknown	unknown	gnl|CDD|179143
NZ_CP014870.1|WP_064677848.1|3305629_3307009_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|223936
NZ_CP014870.1|WP_064677849.1|3308041_3310228_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064677862.1|3326784_3328443_-|AMP-binding-protein	unknown	unknown	gnl|CDD|341277
NZ_CP014870.1|WP_064677857.1|3319459_3320167_+|HPP-family-protein	unknown	unknown	gnl|CDD|225979
NZ_CP014870.1|WP_064677861.1|3326000_3326762_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187629
NZ_CP014870.1|WP_064677854.1|3316102_3316951_+|polysaccharide-deacetylase	unknown	unknown	gnl|CDD|200563
NZ_CP014870.1|WP_082930476.1|3322707_3323481_-|enoyl-CoA-hydratase	unknown	unknown	gnl|CDD|180295
NZ_CP014870.1|WP_064677858.1|3320445_3321552_+|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|379770
NZ_CP014870.1|WP_064677856.1|3318122_3319301_+|MFS-transporter	unknown	unknown	gnl|CDD|182213
NZ_CP014870.1|WP_064677863.1|3328719_3329730_-|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|378890
NZ_CP014870.1|WP_064677850.1|3310477_3311446_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NZ_CP014870.1|WP_064677859.1|3323514_3324642_-|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|173847

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064677852.1|3314247_3315012_+|amino-acid-ABC-transporter-ATP-binding-protein	gnl|CDD|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.21436e-149
NZ_CP014870.1|WP_064680713.1|3306975_3308049_-|tryptophan-7-halogenase	gnl|CDD|223717	COG0644, FixC, Dehydrogenases (flavoproteins) [Energy production and conversion].	2.07109e-34
NZ_CP014870.1|WP_064677853.1|3315065_3315890_+|ABC-transporter-substrate-binding-protein	gnl|CDD|270225	cd01004, PBP2_MidA_like, Mimosine binding domain of ABC-type transporter MidA and similar proteins; the type 2 periplasmic binding protein fold. This subgroup includes the periplasmic binding component of ABC transporter involved in uptake of mimosine MidA and its similar proteins. This periplasmic binding domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	8.62889e-84
NZ_CP014870.1|WP_064677855.1|3316943_3317831_+|polysaccharide-deacetylase	gnl|CDD|200563	cd10938, CE4_HpPgdA_like, Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins. This family is represented by a peptidoglycan deacetylase (HP0310, HpPgdA) from the gram-negative pathogen Helicobacter pylori. HpPgdA has the ability to bind a metal ion at the active site and is responsible for a peptidoglycan modification that counteracts the host immune response. It functions as a homotetramer. The monomer is composed of a 7-stranded barrel with detectable sequence similarity to the 6-stranded barrel NodB homology domain of polysaccharide deacetylase (DCA)-like proteins in the CE4 superfamily, which removes N-linked or O-linked acetyl groups from cell wall polysaccharides. In contrast to typical NodB-like DCAs, HpPgdA does not exhibit a solvent-accessible polysaccharide binding groove, suggesting that the enzyme binds a small molecule at the active site.	8.93038e-99
NZ_CP014870.1|WP_064677864.1|3329729_3331073_-|CDP-diacylglycerol--serine-O-phosphatidyltransferase	gnl|CDD|236510	PRK09428, pssA, CDP-diacylglycerol--serine O-phosphatidyltransferase.	0
NZ_CP014870.1|WP_064677860.1|3324794_3325988_-|acetyl-CoA-C-acyltransferase	gnl|CDD|180775	PRK06954, PRK06954, acetyl-CoA C-acetyltransferase.	0
NZ_CP014870.1|WP_046047004.1|3313358_3314237_+|amino-acid-ABC-transporter-permease	gnl|CDD|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	6.51791e-76
NZ_CP014870.1|WP_064677863.1|3328719_3329730_-|AraC-family-transcriptional-regulator	gnl|CDD|378890	pfam12625, Arabinose_bd, Arabinose-binding domain of AraC transcription regulator, N-term. AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	1.75391e-38
NZ_CP014870.1|WP_064677848.1|3305629_3307009_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl|CDD|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NZ_CP014870.1|WP_064677851.1|3311777_3313205_+|argininosuccinate-lyase	gnl|CDD|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NZ_CP014870.1|WP_064677862.1|3326784_3328443_-|AMP-binding-protein	gnl|CDD|341277	cd05973, MACS_like_2, Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS). MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.	0
NZ_CP014870.1|WP_064677857.1|3319459_3320167_+|HPP-family-protein	gnl|CDD|225979	COG3448, COG3448, CBS-domain-containing membrane protein [Signal transduction mechanisms].	2.54628e-52
NZ_CP014870.1|WP_064677861.1|3326000_3326762_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187629	cd05371, HSD10-like_SDR_c, 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs. HSD10, also known as amyloid-peptide-binding alcohol dehydrogenase (ABAD), was previously identified as a L-3-hydroxyacyl-CoA dehydrogenase, HADH2. In fatty acid metabolism, HADH2 catalyzes the third step of beta-oxidation, the conversion of a hydroxyl to a keto group in the NAD-dependent oxidation of L-3-hydroxyacyl CoA. In addition to alcohol dehydrogenase and HADH2 activites, HSD10 has steroid dehydrogenase activity. Although the mechanism is unclear, HSD10 is implicated in the formation of amyloid beta-petide in the brain (which is linked to the development of Alzheimer's disease). Although HSD10 is normally concentrated in the mitochondria, in the presence of amyloid beta-peptide it translocates into the plasma membrane, where it's action may generate cytotoxic aldehydes and may lower estrogen levels through its use of 17-beta-estradiol as a substrate. HSD10 is a member of the SRD family, but differs from other SDRs by the presence of two insertions of unknown function. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.53552e-117
NZ_CP014870.1|WP_064677854.1|3316102_3316951_+|polysaccharide-deacetylase	gnl|CDD|200563	cd10938, CE4_HpPgdA_like, Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins. This family is represented by a peptidoglycan deacetylase (HP0310, HpPgdA) from the gram-negative pathogen Helicobacter pylori. HpPgdA has the ability to bind a metal ion at the active site and is responsible for a peptidoglycan modification that counteracts the host immune response. It functions as a homotetramer. The monomer is composed of a 7-stranded barrel with detectable sequence similarity to the 6-stranded barrel NodB homology domain of polysaccharide deacetylase (DCA)-like proteins in the CE4 superfamily, which removes N-linked or O-linked acetyl groups from cell wall polysaccharides. In contrast to typical NodB-like DCAs, HpPgdA does not exhibit a solvent-accessible polysaccharide binding groove, suggesting that the enzyme binds a small molecule at the active site.	1.2251e-113
NZ_CP014870.1|WP_082930476.1|3322707_3323481_-|enoyl-CoA-hydratase	gnl|CDD|180295	PRK05862, PRK05862, enoyl-CoA hydratase; Provisional.	1.24696e-155
NZ_CP014870.1|WP_064677858.1|3320445_3321552_+|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|379770	pfam16113, ECH_2, Enoyl-CoA hydratase/isomerase. This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.	1.45896e-165
NZ_CP014870.1|WP_064677856.1|3318122_3319301_+|MFS-transporter	gnl|CDD|182213	PRK10054, PRK10054, efflux MFS transporter YdeE.	2.56616e-59
NZ_CP014870.1|WP_064677850.1|3310477_3311446_-|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.06098e-32
NZ_CP014870.1|WP_064677859.1|3323514_3324642_-|acyl-CoA-dehydrogenase-family-protein	gnl|CDD|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0

Protein sequences

>NZ_CP014870.1|WP_064677855.1|3316943_3317831_+|polysaccharide-deacetylase
MADSIVWPKGYRCAVVLTVDYNDVHGILTQAPEVAGRDKTLSVWRYGSQRGVERLLGLFAELGVPGSWCIPGIVAEENPDHIRAIQAGGHEIACAGYRHQNYDSLDLAAQRAEIAKGCAALTALTGQRPTGFRIPAGNGAPGFIEALKDHGIRWSSSWRGDDLPFAHPTAPEVIELPLHYELEDEPYFAFNLSPAVPPAQSRIASYSHTLGNLQMDFAGFHRFGLCYVLRLHPEIIATPGRIGVLRELLEGIQRHEDVWIATGADVARWWAESAPPVTEDHPASVYERHYRDYLL
>NZ_CP014870.1|WP_064677854.1|3316102_3316951_+|polysaccharide-deacetylase
MSSSPQPTWPAPHKACLALAFDLDGPTGDAMLNGSIWRKPEYFGFGGYGPYRALPRILDLLDEFRIPTTFFVPAWVVENWPRQCQAIVERGHEVAYHGYKHESFYALTLEQQKDVMSKSREVFWKYLHIRAEGFRTPSGDWRAETPAMLVEAGVTYSSSMRGDDRPYLVKVPGFATPLVEIPGRWEMDDYASIAYTRAPDFPSGLDRTASYELTLDNWCREYDGAMNEGLCLTTLFHPKITGKPGRILLLEKLFEHMRQRDDVWFATCRDVAHWWVKEHHHG
>NZ_CP014870.1|WP_064677853.1|3315065_3315890_+|ABC-transporter-substrate-binding-protein
MKNFVIPAVLASVMASGFTFAAELPASIKAKGEVVVAIMPNYPPMDFKDPATNTLTGLDVDLGNALAERLGVKIKWQETGFEQMINALTTDRVDMVMSGMTDTAERQASVTFVDYFTSGPQFYTLQKNKDTNEIIDLCGKKVGTSRRTTFPAEIAEWSKANCEAAGKPAINVIGTEGSADARAQLRQSRIDAAMQGSETLSYLKNQEKDMYKTVGLPISEQFTGLGVSKKKPELSEALKVALQSMIDDGTYQTILKKWDLELGAIKTVTINAGK
>NZ_CP014870.1|WP_064677852.1|3314247_3315012_+|amino-acid-ABC-transporter-ATP-binding-protein
MRSIVKAVSLNKYYDHFHALKDVNIEVEQGEVLCIIGPSGSGKSTLLRCINQLEKIDKGGLWVDGELVGYRIAGNKLYELNESQIARQRLSTGMVFQRFNLFPHMTVLQNIIEGPCQVLKRSPKEAHEEAVELLARVGLADKRNSYPIELSGGQQQRVAIARALAMRPKLMLFDEPTSALDPELVGEVLSVMRDLAQTGMTMIVVTHELGFAREVSNRMVFMDGGQIVEAGSPEEILISPQNPRTQSFISAVRT
>NZ_CP014870.1|WP_046047004.1|3313358_3314237_+|amino-acid-ABC-transporter-permease
MSQTQAERLQAERKLAENQFDITQYHHVPRRYYGRIFFATVIVIAILGLVRAFAEGKIEWSYIGQFLTSQAIMWGLLNTIVMAVLAMALGIVFGVITAIMRMSANPILRYVAVTYTWLFRGTPLILQLLLWFNLALIFPTIGIPGLFEMDTVSLMTPFVAALLGLSINQGAYTAEVVRAGLLSVDTGQYEAAKSIGMPRLQALRRIILPQAMRVIIPPVGNEFIGMVKMTSLASVIQYSELLYNAQNIYYANARVMELLIVAGIWYLATVTVLSFGQSRLERRFARGAGKRS
>NZ_CP014870.1|WP_064677851.1|3311777_3313205_+|argininosuccinate-lyase
MSQTTDRLWGARFKTGPSEALAALSRCPERYFRLTPYDLAGSRAHARELQRAGLLNEQETRTMVDALERIGADFRAGSIAPTLEDEDVHTFIERLLTERLGALGGKLRAGRSRNDQTANDLRLFLRDHVRTLAVEVLALQQALVAQAEQHVDSICPGFTHLQQAQPIVFAHHLLAHAQSMLRDVQRLVDWDVRTSLSPLGAAAMAGSAIARQPQQSAREMGYSGVCENSIDAVASRDHVAEFLFIASMLGINISRLAEEFCLWSSRQFRWVALDDAYATGSSIMPQKKNPDIAELARGKAGRLIGNLTGLLSTLKSLPLSYNRDLSEDKHGVLDSVDTLLLVLPAMAGMVATMTVNVEELRRQAPLGFTLATEVADWLAMRGVPFKEAHEITGALVQACEKRDIELWEASAALLAEIDPRLTPEVRESLTLEAAIAARSGWGGTAPQQVREQIGRLKTALAAQQRWTEDYQGFRL
>NZ_CP014870.1|WP_064677850.1|3310477_3311446_-|LysR-family-transcriptional-regulator
METPLSNSGNPPLKTSHRAPLTLSGLDFKLLKVFKAVVEAGGFSAAQNELNVGLAAISKQISDLEIRIGMRLCTRGREGFHLTEEGSLVYQASIDLFASVDNFRDRLSSAQNELIGDLGVGVIDNTISDAQSPLVAALKQINEASPKVRFQLQTSQLDEVERGVVEGRLLAGIVPVYQRREEFDYYALYEERSEVYCAIGHPLFTLPEVEMGSNVLKDYECINHRYAIHRDKLNFTHYDSFSASATQVEAVALLIKTGRFVGFLPRHYAASLVAQGQFRAVRPDLIHIDTPFNLILRHNTVRSPLVKAFARALGVDLKATVG
>NZ_CP014870.1|WP_064677849.1|3308041_3310228_-|hypothetical-protein
MALIDEVKIICDRLAMDAGWHDLLLQHGLDIKACPLEAELKKQLPVDRTVNGFEDFSLKGNCAIEAGNPSRSLLYHAFASPNVTTDSKGNALTIYPTAAEIETVLNYVYGVCPPGLEALFEQAGEGAVLAIVVFAIEYRPGPGTVHGKHADLCFSRTGIARVGTAPAWYDPQRRGFLPWVEDDPKAIRVMPARFSAYIAVQRKGDAARFGPQSFQPGDEERDFWTPLHKLFEGTECIAGMELNVNLECYHINDKLRRFHLKFPEPDWQEPVLSGPPFVLTDGLAHWADETGSGQGLLLPVAQRGLVEKATYDHQDVFFTIPAEPNYRGYIINRRYKLLEDGSIDDLNLNPDVVNIVKAGGYRALHFIDFTAEGWVRASCPMLETVIPDNAVAYSIIAAPDFYPASSQRELLEWSDQQQFPQPFFGQSLRVLSNLRAAGNPDLNGNYFQPDDKGVTAIVSHPVEVEDRAASGARTTNGRASWLSDRAAGSLSPGWEISGPDGGGPRPASLCGYELGSPFTEDVRICASIGGYWPAVSPDTSRTFEPNASRVPIIPLTDEEGGQADSGSWDGVDGPRLLTDAQGKQVVEYTAFDHCDYTKNALAGLLSLHRTAQTSADDYARRIWTLHNAFTALGASTRQQKAEWSVLSFRKITRPHAALEFAEQEAGAVLQGDIHCYQIYKPDKGSLSTPPGDFTKRQVEILEMTCSFVGEEALLSKRGDAAWTVQYLG
>NZ_CP014870.1|WP_064680713.1|3306975_3308049_-|tryptophan-7-halogenase
MGDYDVVVIGAGPAGCAAAIFCARHGLRVALLEQCAFPRERPGETLPPGIEPLLQQLDVADVVVQGDFIRHTGHWVQWGAERRFSAFGGEPATPWCGFQIPRATFDSLLLEKAVERGVHVVQPCRVNEVIRHNDRVIGARTTAGEFFSRQLIDASGSHSWLMRQLALDHSLFSPLLIAKYGYATGERAACDEAPGIVADAQGWYWTARVAPKLYNWTRLYFDKAQARQAGPPAMFDHLTAVGGIRGADVTWRSCHRTAGNGYFIVGDAAFVLDPGTSHGVLKAIMSGMMAAHAIIRENAFPRHRSAINTQYRQWMQRWFVRDMNAMGELYRSHPSPPHWLSMTDRRNQATTEAAGHR
>NZ_CP014870.1|WP_064677848.1|3305629_3307009_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MKISVFGSGYVGLVQAAVLAEVGHDVVCMDIDPQKVELLQQGHVSIFEPGLASLVRENLDARRLQFTTDEKLAVQHGQVLFIAVGTPSRDDGSADLRYVMAVGEAVARHREQPVILVEKSTVPVGTGDALRAHIDKCLLKVGRLLQFDIVSNPEFLKEGSAVADCRRPDRIIIGCDRDDIREVMRDLYGPFNRNHDRIMFMDLRSAELTKYAANCMLATKISFINQIAELAEHLGADIESVRLGIGADSRIGYHFIYPGCGYGGSCFPKDMRALIHSAEQAQCSSDLLQAVEAINQRQKHKLFERINAFYQGDLRGRTFALWGLAFKPNTDDMRDAPSRVLLEALWAAGANVRAFDPEAMQQTRQLYPHESKLMLMGTPESALSGADALIICTEWQQFKAPDFNLIQQRLNAPVIFDGRNLYDAERLARAGFLYFPIGRGESRGLPIPLQRWPAASVVA
>NZ_CP014870.1|WP_064677856.1|3318122_3319301_+|MFS-transporter
MATYSLVIRRLMIVSLTIVVSRAITSPLLTLFLSNKLGLNQQDVGLLLGIAVFIATLLALYGGYIIDRLEKRRLLILAMLSSAIGFVLLTFADNLYLTTATLVITETASALFLIGSKAILSENLPMGQRAKAFSLRYTLTNIGYATGPMLGVVIAGVYPIAPFLIAGGIAFFSIFLMIGIPRDSALTPAIGQPQSFLKTLVTLKNDRTLIMFTCGCLLSTVVHGRFTLYLSQYLLVTEDSKRALETMAALLACNAISVILLQYQIGRFLKREQLRYWIAGGTSLFIVGLIGFSLADSLVSWCVAMFIFTLGEMIIYPAEFLFVDTLAPEELRGSYYGAQNLAALGGALSPVICGYLLLHSPAPTMFYALSALTAMGGFLCFMSGRRVAMHQK
>NZ_CP014870.1|WP_064677857.1|3319459_3320167_+|HPP-family-protein
MFARWLPAAINTRPSEWSRAAIGMSLGTMFSVWLCSQVFGMQVAQHLIGPLGASAVLLFAVSSGALAQPWSILGGYLSAGVVSLLVAHVLGRTLGSACLAAGMALILMCWLRCLHPPAGALALLLVLADPATIALDWKALGPVMLSASTMLLSALTYNNLTRIRYPRRAGEPVAVVPADHPPIDSQAITAQDLKLALAEMEAFFDVTPEDLEQLIHISELHAKRRSIGEVLNQSY
>NZ_CP014870.1|WP_064677858.1|3320445_3321552_+|enoyl-CoA-hydratase/isomerase-family-protein
MTAQVFSPGTSSMDATQNEVLAEVRNHIGHLTLNRPAGLNALTLDMVRTLQRQLDVWAQDSQVHAVVMRGAGEKAFCAGGDIRSLYDSFKNGDTLHEDFFVEEYALDLAIHDYCKPVLALMDGFVLGGGMGLVQGADLRVVTEKSRLAMPEVAIGYFPDVGGSHFLPRVPGELGIYLGVSGVQIRAADALYCGLADWYLESSKLGTLDEQLDQLQWHDTPLKDLQGLLAKLAVQHLPDAPLSVLRPAIDHFFALPDVPSIVEQLREVTVADSHEWALTTADLLESRSPLAMGVTLEMLRRGRHLSLEHCFALELHLDRQWFERGDLIEGVRALLIDKDKSPRWNPPTLQALDAGHVASFFSGFDPSWS
>NZ_CP014870.1|WP_082930476.1|3322707_3323481_-|enoyl-CoA-hydratase
MSYETILLETHGRVGLITLNRPQALNALNAQIVSELNQALDGLEADSNIGCIVLTGSKKAFAAGADIKEMVELTYPQIYLDDLFSDSDRVANRRKPIIAAVNGFALGGGCELALMCDFILAGDNAKFGQPEINLGVLPGMGGTQRLTRAVGKAKAMEMCLSGRLIDAVEAERCGIVARIVPADELVEEALKVAAKIAAKSLPIAMMVKESVNRAFEVSLSEGVRFERRVFHAAFATQDQKEGMAAFIAKREAEFKGK
>NZ_CP014870.1|WP_064677859.1|3323514_3324642_-|acyl-CoA-dehydrogenase-family-protein
MIPNDDQQQIRDMARQFADERLKPFAAEWDREHRFPKDAIGEMAQLGFFGMLVPEEWGGCDTGYLAYAMALEEIAAGDGSCSTIMSVHNSVGCVPILKYGNDDQKERFLKPLASGAMLGAFALTEPQAGSDASGLKTRARLNGDHYVLNGCKQFITSGQNAGVVIVFAVTDPAAGKRGISAFIVPTDSPGYKVARVEDKLGQHASDTCQILFEDVKVPLANRLGEEGEGYRIALANLEGGRVGIASQSVGMARAAFEAARDYARERESFGKPIIEHQAVAFRLADMATQIAVARQMVHYAAALRDSGKPALVEASMAKLFASEMAEKVCSSALQTLGGYGYLNDFPLERIYRDVRVCQIYEGTSDIQRMVISRNL
>NZ_CP014870.1|WP_064677860.1|3324794_3325988_-|acetyl-CoA-C-acyltransferase
MTIANDPIVIVSAVRTPMGGFQGELKSLTAPQLGAAAIKAAVERAGIAPDAVEEVLFGCVLPAGLGQAPARQAALGAGLDKSTRCTTLNKMCGSGMEAAILAHDMLVAGSAEVVVAGGMESMSNAPYLLDRARSGYRMGHGRVLDHMFLDGLEDAYDKGRLMGTFAEDCAETNGFTREAQDAFAIASTTRAQQAIKDGSFKDEIVPLTVTVGKEQVVISHDEQPPKARLDKIASLKPAFRDGGTVTAANSSSISDGAAALVLMRRSEAEKRGLKPLAVIHGHAAFADTPGLFPVAPVGAIQKLMKKTGWSLDEVDLVEVNEAFAVVSLVTMTKLEIPHEKINVHGGACALGHPIGASGARILVTLLSALRQKGLKRGVAAICIGGGEATAMAVECLY
>NZ_CP014870.1|WP_064677861.1|3326000_3326762_-|SDR-family-NAD(P)-dependent-oxidoreductase
MQIANKVFLVTGGASGLGAATAEMLVAAGAKVMLVDMNAEAVAAQAQRLGAQSVVADISNEAAAEAAVLATVKAFGGLNGLVNCAGIVRGEKILGKTGPHVLANFSQVINVNLIGSFNMLRLAAAAIAETEADADGERGVIINTASAAAYDGQIGQAAYAASKGAIVSLTLPAARELARFGIRVMTIAPGIFETPMMAGMTPEVRASLAAGVPFPPRLGKPDEYAGLVRHIIENSMLNGEVIRLDGALRMAAK
>NZ_CP014870.1|WP_064677862.1|3326784_3328443_-|AMP-binding-protein
MRDYLSATSQFDYQHTVDAALAGDLTALNACIECCDRHALPGRIALFWEGRDGASATYTFTDLQDKAARFANFLLAQGVKKGDKVAGLLPRNIELLITVFATWRIGAVYQPLFTAFGPKAIEHRLNSSGAKVVVTDAVNRSKLCEVADCPTIVTVAGPKGQGIVQGDYSFWAELANYPAECEPVLLTGEDPFLLMFTSGTTGPSKALSVPLKAIVAFQSYTRDAVDLRPEDAFWNVADPGWAYGIYFGVTGPMAMGHPITFYDGPFTLESTCRVINKYGITNLTGSPTAYRLLIAGGNEFARSIKGKLRIVSSAGEPLNPEVIRWFADNLGVVIHDHYGQTELGMVLCNHHALEHPIHMGAAGFASPGHRIVVLDEEYKELGVGQPGILAIDRTQSPMCWFGGYEGAPTKAFVGNYYLSGDTVEWNPDGSISFVGRSDDVITTSGYRVGPFDVESALIEHPAVVEAAVVGKPDPERTELVKAFVVLSAQYRPEPELAEELRQHVRKRLAAHSYPREIEFVSELPKTPSGKLQRFILRNQEIAKAQEAAAKNL
>NZ_CP014870.1|WP_064677863.1|3328719_3329730_-|AraC-family-transcriptional-regulator
MSEKDTISMQLVREALLQSCAPGAATEEVLNKVGIDPALLQTADARVPATAYARLWRLLARRGDDEFFGMDPRKLKSGSLAFLCQCSMVQPNLAAALASGLGFLSLMLEHLPAQLVRQQSLAEIVLQEDDQDPRRAFTYFTYWMIVHGVACWLAGRRIPILAIELRCPEPDFCDDYQVMFSENLRFDRPRTRMIFSAECLDLPIKRTAEELKRFLAQAPANILVKYRDPQSLASRIKHDLRQLPAEHWPETEALAQRLCMSASTLRRRLAEEGQTYQGLKDSVRKELAIVWLAEPSISFAEIATRLGFADASSFYKAFRKWSGSNPGHYRSLILND
>NZ_CP014870.1|WP_064677864.1|3329729_3331073_-|CDP-diacylglycerol--serine-O-phosphatidyltransferase
MPSLFKRSLLPKLRSFPLTADAVTILSGAAEFRRCLLEKIAQATRRIYIVALYLQQDEAGQEILDALHAAKLARPELDVVVVVDWLRAQRGLIGAGKQPGNSAWYQETTRTHESVVPVYGVPVQTRELFGVLHLKGFVIDDCVIYSGASLNNVYLHKFDKYRYDRYHLLHNSALADSMQHLIQHGLIASKAVHRLDLPNLPTTRSLRNDIGDLRSRLKHAAYDTTAGTAAKDGLTVSPLLGVGKNNPLSRVICELIASARDQLTICTPYFNLPLAVTREINRALARGVKIDIVVGDKTANDFYIPPSEPFKVIAALPYLYEISLRRFAKRHHRSIDSGLLNLHLWKDGDNTYHLKGMWIDQRYTLLTGNNINPRAFRLDLENALLIDDPKGELLAPRRNELDEIFQHTRRIARYQELDTLLEYPPAVAKFLKRVSRVRIERLLYRIL

Crispr_ID: NZ_CP014870_11

• CRISPR_ID: NZ_CP014870_11
• CRISPR_location: 4105114-4105194
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_11

Consensus_repeat	Method
GAAAGCGCTTGCGCAAGCGCTTTCCT	CRISPRCasFinder

spacers of NZ_CP014870_11

>11.1|4105140|29|NZ_CP014870|CRISPRCasFinder
AACTTTCAAAAATCCCTCCACAGACAAAG

CRISPR arrays and Neighbor proteins around NZ_CP014870_11

CRISPR arrays

The CRISPR arrays of NZ_CP014870_11

>merge|NZ_CP014870|11|4105114-4105194|CRISPRCasFinder
GAAAGCGCTTGCGCAAGCGCTTTCCTAACTTTCAAAAATCCCTCCACAGACAAAGGAAAGCGCTTGCGCAAGCGCTTTCCT

>NZ_CP014870|11|10|4105114-4105194|CRISPRCasFinder
GAAAGCGCTTGCGCAAGCGCTTTCCT	AACTTTCAAAAATCCCTCCACAGACAAAG
GAAAGCGCTTGCGCAAGCGCTTTCCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064678473.1|4095087_4095876_-|electron-transfer-flavoprotein-subunit-beta	unknown	unknown	gnl|CDD|238847
NZ_CP014870.1|WP_082930484.1|4110714_4111389_-|tRNA-(adenine(22)-N(1))-methyltransferase-TrmK	unknown	unknown	gnl|CDD|225258
NZ_CP014870.1|WP_064678471.1|4093120_4094071_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176114
NZ_CP014870.1|WP_064678487.1|4114988_4116053_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP014870.1|WP_064678475.1|4098304_4099261_-|threonine-dehydratase	unknown	unknown	gnl|CDD|235699
NZ_CP014870.1|WP_064678482.1|4108942_4109602_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|236442
NZ_CP014870.1|WP_064678483.1|4109706_4110645_+|carbohydrate-kinase	unknown	unknown	gnl|CDD|238572
NZ_CP014870.1|WP_064678481.1|4107899_4108826_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380544
NZ_CP014870.1|WP_064678479.1|4105274_4106834_+|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224053
NZ_CP014870.1|WP_064678472.1|4094131_4095091_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl|CDD|224936
NZ_CP014870.1|WP_064678476.1|4099357_4100170_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
NZ_CP014870.1|WP_064678480.1|4106830_4107853_+|ribose-ABC-transporter-permease	unknown	unknown	gnl|CDD|226633
NZ_CP014870.1|WP_064678477.1|4100314_4101541_-|carbohydrate-porin	unknown	unknown	gnl|CDD|367007
NZ_CP014870.1|WP_082930365.1|4103810_4104815_-|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP014870.1|WP_064678474.1|4095878_4097258_-|flavocytochrome-c	unknown	unknown	gnl|CDD|273816
NZ_CP014870.1|WP_082930364.1|4097254_4098079_-|racemase	unknown	unknown	gnl|CDD|226611
NZ_CP014870.1|WP_064678485.1|4111662_4113789_+|TonB-dependent-receptor	unknown	unknown	gnl|CDD|238657
NZ_CP014870.1|WP_064678478.1|4101752_4103417_-|glucose-6-phosphate-isomerase	unknown	unknown	gnl|CDD|234679
NZ_CP014870.1|WP_064678486.1|4113893_4114664_-|aminoglycoside-3'-phosphotransferase	unknown	unknown	gnl|CDD|270699
NZ_CP014870.1|WP_064678488.1|4116155_4117241_-|AbrB-family-transcriptional-regulator	unknown	unknown	gnl|CDD|377472

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064678473.1|4095087_4095876_-|electron-transfer-flavoprotein-subunit-beta	gnl|CDD|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	2.33666e-22
NZ_CP014870.1|WP_082930484.1|4110714_4111389_-|tRNA-(adenine(22)-N(1))-methyltransferase-TrmK	gnl|CDD|225258	COG2384, COG2384, Predicted SAM-dependent methyltransferase [General function prediction only].	4.75253e-69
NZ_CP014870.1|WP_064678471.1|4093120_4094071_+|LysR-family-transcriptional-regulator	gnl|CDD|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.40224e-62
NZ_CP014870.1|WP_064678487.1|4114988_4116053_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.54579e-27
NZ_CP014870.1|WP_064678475.1|4098304_4099261_-|threonine-dehydratase	gnl|CDD|235699	PRK06110, PRK06110, threonine dehydratase.	0
NZ_CP014870.1|WP_064678482.1|4108942_4109602_+|AAA-family-ATPase	gnl|CDD|236442	PRK09270, PRK09270, nucleoside triphosphate hydrolase domain-containing protein; Reviewed.	3.89995e-80
NZ_CP014870.1|WP_064678483.1|4109706_4110645_+|carbohydrate-kinase	gnl|CDD|238572	cd01167, bac_FRK, Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.	2.17464e-95
NZ_CP014870.1|WP_064678481.1|4107899_4108826_+|ABC-transporter-substrate-binding-protein	gnl|CDD|380544	cd06321, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of uncharacterized ABC-type transport systems. This group includes the periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consist of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	3.88495e-116
NZ_CP014870.1|WP_064678479.1|4105274_4106834_+|sugar-ABC-transporter-ATP-binding-protein	gnl|CDD|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NZ_CP014870.1|WP_064678472.1|4094131_4095091_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl|CDD|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	6.76188e-54
NZ_CP014870.1|WP_064678476.1|4099357_4100170_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	9.28451e-25
NZ_CP014870.1|WP_064678480.1|4106830_4107853_+|ribose-ABC-transporter-permease	gnl|CDD|226633	COG4158, COG4158, Predicted ABC-type sugar transport system, permease component [General function prediction only].	2.77261e-118
NZ_CP014870.1|WP_064678477.1|4100314_4101541_-|carbohydrate-porin	gnl|CDD|367007	pfam02264, LamB, LamB porin. Maltoporin (LamB protein) forms a trimeric structure which facilitates the diffusion of maltodextrins across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an antiparallel beta-barrel.	5.44464e-141
NZ_CP014870.1|WP_082930365.1|4103810_4104815_-|LacI-family-DNA-binding-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.61411e-116
NZ_CP014870.1|WP_064678474.1|4095878_4097258_-|flavocytochrome-c	gnl|CDD|273816	TIGR01813, Fumarate_reductase_flavoprotein_subunit, flavocytochrome c. This model describes a family of redox proteins related to the succinate dehydrogenases and fumarate reductases of E. coli, mitochondria, and other well-characterized systems. A member of this family from Shewanella frigidimarina NCIMB400 is characterized as a water-soluble periplasmic protein with four heme groups, a non-covalently bound FAD, and essentially unidirectional fumarate reductase activity. At least seven distinct members of this family are found in Shewanella oneidensis, a species able to use a wide variety of pathways for respiraton. [Energy metabolism, Electron transport].	7.76542e-86
NZ_CP014870.1|WP_082930364.1|4097254_4098079_-|racemase	gnl|CDD|226611	COG4126, COG4126, Hydantoin racemase [Amino acid transport and metabolism].	7.84439e-20
NZ_CP014870.1|WP_064678485.1|4111662_4113789_+|TonB-dependent-receptor	gnl|CDD|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	2.12898e-40
NZ_CP014870.1|WP_064678478.1|4101752_4103417_-|glucose-6-phosphate-isomerase	gnl|CDD|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0
NZ_CP014870.1|WP_064678486.1|4113893_4114664_-|aminoglycoside-3'-phosphotransferase	gnl|CDD|270699	cd05150, APH, Aminoglycoside 3'-phosphotransferase. APH catalyzes the transfer of the gamma-phosphoryl group from ATP to aminoglycoside antibiotics such as kanamycin, streptomycin, neomycin, and gentamicin, among others. The aminoglycoside antibiotics target the 30S ribosome and promote miscoding, leading to the production of defective proteins which insert into the bacterial membrane, resulting in membrane damage and the ultimate demise of the bacterium. Phosphorylation of the aminoglycoside antibiotics results in their inactivation, leading to bacterial antibiotic resistance. The APH gene is found on transposons and plasmids and is thought to have originated as a self-defense mechanism used by microorganisms that produce the antibiotics. The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.76501e-107
NZ_CP014870.1|WP_064678488.1|4116155_4117241_-|AbrB-family-transcriptional-regulator	gnl|CDD|377472	pfam05145, AbrB, Transition state regulatory protein AbrB. Bacillus subtilis respond to a multitude of environmental stimuli by using transcription factors called transition state regulators (TSRs). They play an essential role in cell survival by regulating spore formation, competence, and biofilm development. AbrB is one of the most known TSRs, acting as a pleotropic regulator for over 60 different genes where it directly binds to their promoter or regulatory regions. Many other genes are indirectly controlled by AbrB since it is a regulator of other regulatory proteins, including ScoC, Abh, SinR and SigH. Hence, AbrB is considered a global regulatory protein controlling processes such as Bacillus subtilis growth and cell division as well as production of extracellular degradative enzymes, nitrogen utilization and amino acid metabolism, motility, synthesis of antibiotics and their resistant determinants, development of competence, transport systems, oxidative stress response, phosphate metabolism, cell surface components and sporulation. AbrB is a tetramer consisting of identical 94 residue monomers. Its DNA-binding function resides solely in the N-terminal domain (AbrBN) of 53 residues. Although it does not recognize a well-defined DNA base-pairing sequence, instead, it appears to target a very weak pseudo consensus nucleotide sequence, TGGNA-5bp-TGGNA, which allows it to be rather promiscuous in binding. The N-terminal domains of very similar sequences are present in two more Bacillus subtilis proteins, Abh and SpoVT. Mutagenesis studies suggest that the role of the C-terminal domain is in forming multimers.	1.33994e-73

Protein sequences

>NZ_CP014870.1|WP_082930365.1|4103810_4104815_-|LacI-family-DNA-binding-transcriptional-regulator
MGAKMSDVARAANVSMSTVSHVLNGTRKVHPDTVRNVNQAVEAVGYIRNSLARSLARSSSGAIGVAIATLSNYYFSETVRAIEAACAKSGLMMILVNTQKDPEQELKAVKALHERRVDGIVLASEYDPENRVFNYLKANNIPTVLIDRLLSTSFDQVGVENKQSSQELIAHLIKLGHRRIGMVSGRLTQSSSLERIDGYRAALAEAGIAYDEQLVCCGESAIAPAMEATRRLLALEHPPTAIMTANNLMTIGAMQALRAAGLEVPKDIALVGFDDFDWADAFSPRLTVMAQPLEELGAQAVKLLLKRIKQPEGRRQTLRLKPSLIQRDSCGFPK
>NZ_CP014870.1|WP_064678478.1|4101752_4103417_-|glucose-6-phosphate-isomerase
MNNYNKASDVTALPAWRKLLDHRESMNNFSMRDAFRDDGQRFQDFSLAGCGLFLDYSKNLITHQTRSLLVNLAREAGVEQAAHAMFSGEKINCSEGRPVLHTALRRPVGEPLMVDGRNLMRDVHGALAQMTDVVSRIHSHLWRGYNDKVITDVVNIGIGGSFLGPELVSEALAPFARHGVRCHYLANIDGNEFREVTADLNVETTLFIISSKTFGTLETLKNAHACRSWYLAKGGTEEKLYRHFIAVTSNRQAALDFGIREANVFPMWDWVGGRYSLWSAIGLPIALAIGIANFKELLSGAYAMDQHFLNEPLEQNLPVLLAVLGVWYHNFWGAQSYAFLPYDHNLRNFVKHLQQMDMESNGKSVRRDGTPVSYTTGPVIWGGVGCNGQHAYHQLLHQGTPLIPADFIVPVVSHNPVADHQEWLYANCLSQSQALMRGKTLSEAEAELKAKGLSSSEIERLAPHKVIPGNRPSNTVALEVINPHSLGALIALYEHKVFVQGVIWGVNSFDQWGVELGKELGNSVYNLLTRYDAEPADDSSTQGLIDFFRGRHRG
>NZ_CP014870.1|WP_064678477.1|4100314_4101541_-|carbohydrate-porin
MNVKTLSAVLGASFAVGFLPVDAYSADFSGYFRTGVGDSTQGGKQSCFQLPGAQSKYRLGNECEQYLELDLRQDLLSLDDGSVLSVEGMAQFYNEYGHEPKFDGEHGYTRMSQLYAEWSKMPALNGGSFWAGRRYYNRNDINISDYFYWNQSSTGFGFDQVALGDLKYSYVFSRKDNVFQKDFVTRHDVTVSGFNTNPGGEVQLGVSYLDKPSREDAHQGWSVVAQHKQVAFLGGINKFAVQYGRGPGTALGYTGDSTLDQSNKSWRVVEFFDWQMTHAFSGQVELVYQKDTRPDGDDQNWLSVGVRPIYAITDQFKLITEVGRDQVEAADGTRKLTKYTVAPTWSPKGPGFWDRPEIRLYYTYATWNKAAQRAAGLQSPGSALSDTGAFGTDLHGSNVGVQVEYWWK
>NZ_CP014870.1|WP_064678476.1|4099357_4100170_+|helix-turn-helix-transcriptional-regulator
MVFMNPRNHLPPSLLTEPVRRVEAGPWTIELLPGSAYAARYVASHAAIGFAFDSQQGLHAIGSDRVLPFVATPNGLAFVPAGCDVLSESAEGGEYLRVVRADGMTLIGDQPFNNRIDPQAISLALRMRNALLHASMDDDWEAWALALAERAMAQQVLPTPPRGSITGRRMRLLDEFIDAGLEGSLSVQAMAGLLELSEGFFMRAFKQATGKSPHSYLIDRRLAKARALLRDSTAGLSGIALICGFSSQAHMATAFKQRLGVSPAQLRKRP
>NZ_CP014870.1|WP_064678475.1|4098304_4099261_-|threonine-dehydratase
MHRLTRDDIEQAAHQVYQVMPATAQYPWPLLAERLGCTVWVKHENHTPTGAFKVRGGITFMHWLKRTHPSARGIVTATRGNHGQSLALAARALGLRALIVVPEGNSVEKNQAMRGFGGEVVEWGRDFDEAREEAARLAQTHGLYLVPPFHTELVKGVATYALELFKAAPDLDTVYVPIGCGSGICGVIAARDALGLKTQVVGVVSTEAAAAKLSFEARAICETATANTFADGLAVRKPVPEAFAIYSAAAARIVSVGEEQIAEAMRVYYTDTHNLAEGAGAAALAALIQERDAMAGKRVGVILSGGNVDRAVYAGVIG
>NZ_CP014870.1|WP_082930364.1|4097254_4098079_-|racemase
MSIRIWHQSFTVLSDLGAYDDALRAHFRKVARPGTEIHLHGMLPGTYRNHYPGDDIKYSALQYLHGLQFMAAGINAQHQGFDAYAISTLPEPALKETRSLLDIPVVGYGESAMLTACMLGRTFGVLVFINELAEQITENAVRHGLAGRLTGVRHVGFQFADVLAAFTDPTALIERFRSAARELIAQGAEVIIPGEAPLNVLLASHGINEVDGVPVLDSLGAWVKQAEAMVDLRRANGTSTCNRGYFSAQPAPDRVREVFGFYGLAPFLQGGTQP
>NZ_CP014870.1|WP_064678474.1|4095878_4097258_-|flavocytochrome-c
MNHYECDLLVIGGGLAGFCAALSAAQAGLQVVVLEKTAQTGGSSAMSGGCLAFAGTDLQRSHGIEDSSQRLFDDLVDVGKGECDESLVKLYTDHQLETYQWLKDNGVVFADVIEAASGQSVPRVHNVDPADMVRQLQSAALATDKVEVWLHSRARRLLRNEGGRVTGASVERNGEQQHIMARSAVLLASGGFVQDRELIHRFVPQYDNAVFIGGEGNEGDGLRMAWALGADVRDLPYIKGTFGKHPMDEHNHHACLVVYKGAIAVNQDGRRFVDESQSYKLLGDAVMQQAFGVGYQILDQDIMDSGDNQVRILDFTRRLEEGLFIEAQTLEQLARLIEVPEDVLLAEVAAYNDAVRQGQPPEFGRQHLVHHHGQLRTLERPPFYAYPSTAAVFGTYCGVIVDSGLRVLDVFGEPIEGLLAAGEMIGGFHGAAYMTGSALGKAAVFGRLAGTRPGTASEG
>NZ_CP014870.1|WP_064678473.1|4095087_4095876_-|electron-transfer-flavoprotein-subunit-beta
MKILVLLAGVADIRFPLHPISLNSQGTIDEQGSPRRVLSPFDEAALEVALKLRDASATTQIDVLLLDGANSENLMRSVAAFRPDSLQCLALQPCQLWDARQTATQMAGLIARDYAGHELVLAGREMGDLDEGSIAVLLARRLGRPQFAMAQSGQWQGEHLWLMRERGTCEEWLRVDQPLLASVTNDRRNKLRHPLMKNVMQAKRMTFAHVVASAPVRAGMTLAQLDAAPVIPRLGQCRLLDGDVAEQANALVGWLKEQGVKP
>NZ_CP014870.1|WP_064678472.1|4094131_4095091_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MSRVLTVIPQAWGAQALEAALGAAQQVSGAEGFAAVLIGSQPSAQDAEWAMRAGARQVYQSVHGALGECDEPQVQVAAVGEALRAIPRLGGDVPLVLLPPGPQGEELAALLADGLDGQALGRCLALRFDGDTLLAERAAWGGRMRLCLAITRGPAFACLRAGRALLNAQADADVFTIELHGVLPGALTLDKRESGQHLPPLEGARLVVSGGRGVNEQGFALLEELALSLGGTLGGSLPAVDAGMVPVLRQVGVSGKFVSPQIYLAVGISGTLQHLAGVSLDSCIVAINKDPEADIFKVASLGIVAPWETLLPALLEKLR
>NZ_CP014870.1|WP_064678471.1|4093120_4094071_+|LysR-family-transcriptional-regulator
MDRLWAMQVFVRVVECGSFSRAAESLDIANATVTSSVRKLEDYLGVTLLSRNTRSLRLTDDGEGYFEQCNQVLQLVADMEARVRQKKGEISGQLCIESPAAFARALLCPALPAFTAQHPGLSVALRQTDHAEDLIATGTDVAIRIDSVNDADLVARPLYQAHYVACAAPGLLKRIGTPEQPQDLQPKHCLGIFGAGRYTVSDWTFTLEDEQHQLTPRGDLHFNSTDALIQAALAEQGVIYVLDVFVNGLIRSGELVELFPHWSTGSRSFYTVTPKARFIAPRTRAFIDFILATLDAQRRPASGASIAVRQGRRGLV
>NZ_CP014870.1|WP_064678479.1|4105274_4106834_+|sugar-ABC-transporter-ATP-binding-protein
MLNTGSESPPPALLEMRAISKSFNGVRVLHDIDLSIFPGQIHALMGENGAGKSTLMKILSGAYIADSGTVRIDGCDIRHYGLNEAKRHGISVIYQELSLCANMSVVENIYLGREIRRCGVINHKAMTEGAQGVLKRLGVTFDPHALVGTLSIADQQLVEIARAIHADARILVMDEPTTPLSSKETESLFTLIRQLRDDGVAIIYISHRMAEIYALSDFVSVLRDGHYVGSLDRGTLSADTLVRMMVGRDVSGFYAHERASCTYEQPILRVRNLTDGFKIKDCSFDLYAGEILGIAGLVGSGRTELARLIAGVDAYASGHIELDGEVVAIRSPRDASNAGIAYLTEDRKALGLFLDMSVHDNINVCVLGSDASLTGVVDRSAGNARVKQAIEALNIKASPDINVGALSGGNQQKVLLARLLEMKPRVLFLDEPTSGVDIGAKTEIYKIINALAASGVCVVMISSELPEIVGIADRVLVMCEGKLVAELGDRSGLDITPETIIAFATGSDSLTLANGDLVQ
>NZ_CP014870.1|WP_064678480.1|4106830_4107853_+|ribose-ABC-transporter-permease
MTSPLQRKVASDFITPNARNIAGPGAQEKMRQMMRVAGMLPVLLLLCVGFSLMSDSFFSAQNFSIISQQASINVVLASGLTFVILTGGIDLSVGSILAVSAVVALLVSQVPGLAGLAIPAGLGIGLLLGLVNGVLVAFGKLPAFIVTLGGLTAMRGIARLIGEDKTVFNPDLSFAYIGNDTLFGVPWLVVIALVVVTLSWLILRRTVLGVQIYAVGGNPEAARLSGIKVWKVLLFVYAISGLLAGVGAIMTSARLMAANGLQMGQSYELDAIAAVILGGTRFTGGVGTIVGTLIGALIIATLSNGLILLGVSDIWQYIIKGVVIIGAVALDRFRQTGART
>NZ_CP014870.1|WP_064678481.1|4107899_4108826_+|ABC-transporter-substrate-binding-protein
MKKTILAAACACLAFNTAQAQELKSVGITVGSLGNPYFVAMVNGAKAQALQINPAAKFTSVSADYDLNKQFTQIDNFISSGVNLILVNAVDPVAIAPAIAKARKAGIVVVGVDVMVQGANATVQTDNVEAGRIVCQYIAEQLGGKGNVIIQNGTQTSAVLDRVNGCKSVFAQAPAIKVLSDNQDAKGSREGGYSVMQGDLTRFAKVDAVFAINDPQAIGADLAAKQLKRKGIIIASVDGAPDIETALKSDTQIQASASQSPWGQAQQAVTMGNDLLNGKALESTTVLLQPSLVTRANVSEYKGWQADH
>NZ_CP014870.1|WP_064678482.1|4108942_4109602_+|AAA-family-ATPase
MYIYANTLVSTALLDYIKALPGYRVVIALAGPPGAGKSTVSEALAQALNNSMPGSAAVIPGDGFHYDDAVLGSLNLLDRKGSPDTFDVGGFRNLLLRLRANNEPTVAVPVFDRRLEISRAAGRLVSSEVKYLIVEGNYLLLNFAPWSSLRNCFDATIMLHVDRKTLEARLLDRWRSFGFDESASYEKVSRNDLPNAELVMSASSEADFTLTDEQPTGSP
>NZ_CP014870.1|WP_064678483.1|4109706_4110645_+|carbohydrate-kinase
MYLVCGEALFDFFSENDAGAKVSTVNYRAIAGGSPFNVAIGLRRLGIDVALLAGLSTDYLGRRLRQTLQEEGVRLDYLQDFDAPTTLAMVAVGADGSPHYSFRGEGCADRQLLPKHLPELDAGVRGLHIGSFSLVVQPIADTLLALVRRESGKRLISLDPNVRLNPEPDIERWRERISTLVEHADLIKVSDEDLNLLYPGLDPQCVIEGWLEHRCQLVFLTRGGQGATVFSRRHGTWSVPAHAVVTVDTVGAGDTFQAALIAWLTEQQSDSVEGLQRLSREQIDAMLGFAVSAAALTCGKTGPDLPFRHQLE
>NZ_CP014870.1|WP_082930484.1|4110714_4111389_-|tRNA-(adenine(22)-N(1))-methyltransferase-TrmK
MRLERVAAQVPAGARLADIGSDHGYLPVALMRRGAIAAAVAGEVALTPFRSAERTVRENGLDLQITVRLASGLEAIEPQDGITAISVCGMGGETIRDILDRGKARLSGQERLILQPNGGEQPLRQWLMDNDYHILYEELLRENRFDYEIIVAERAGPVLYTAEELYFGPLQMQARSPVFLAKWQRKLRHKQRTLADFARARQAVPEEKVQEIARQVRWITELLA
>NZ_CP014870.1|WP_064678485.1|4111662_4113789_+|TonB-dependent-receptor
MPSPKSLPAAMLGLALACPAMAETQSLELGQVLIGAEERSGEDASIEDAKARLAEVPGGTNVVDLRRPLQGRVASNQDVLAYQPGVYAQSAGNEGAKISIRGSGINRAPGAHASGLYAMLDGLPLTGPGGTPYELLEPLWLDHVEVLRGANGFDRGALALGGAIDYISHTGYDAPLLQVRYAMGSHGYQQRQVSSGQVLGDFDYYVAMTDARADGYQDHTASDSQGVIANFGYRFNPNLETRFYLRYRQTDNELAGRVTKHSIEHDPRAANPAYVARDDSREQPGSTFIGNKTTYYIDDDSSIQTGLAYHDYPMDLREGPNRLKVAYTDVSGTFDYKRRDTLWGLESQSTAGLRVTKHLPNAGASERVRIPTGNTAGYAPGTPMRNFTYQGSDTVLHLGNDLEIADDLWLTTGLAAIYTRRESAVTYPQGGGKTSLSDWDYAPRLGLRYQLTPELQLFGNLSRSVEAPHPWSMIYSANQRFPAGSGAATGAQRDPIELQNQTATTLEIGGRGDSTMGQWSLAWYYAQVRHELLSVLPDANATTPYELNASPTVHQGVEASLSSNLWSRDDGGQLSLRQSYTFSDFHYRDDERFGDNRLPGLPMHYYQGELRYDWPQGFFAALNTQWVSKVAVDYANSYYADPYALFGATLGYNAPKGDWQTWLDMRNLTDKHYAGTVTPGYDDKGLDAARSTPGEGLAMYVGVSWSLR
>NZ_CP014870.1|WP_064678486.1|4113893_4114664_-|aminoglycoside-3'-phosphotransferase
MYIPAQWSKTFSGAPIERQTIGESGAEVFRIRCINGKHLFVKSEPIGAHSELPQEIERLRWMNRLDLPGPTVLDVTTENNRHWLLMNAVPGQDLASANDLSAPQVISVLAMALRTLHQVPIETCPFDHSLEQRIAAARSRVSAGLVDEADFDDERQGRTAEEVFTQMLSMLPETYDLAVTHGDACLPNFMVEGSSFTGYIDCGRLGISDIYQDLALAARSIERNLGPAWGAPFFRAYGVEPDQRRIAFYCLLDEFY
>NZ_CP014870.1|WP_064678487.1|4114988_4116053_+|alpha/beta-hydrolase
MKMALQDTTGKTRRRLLGSSLLAFALFGVLGAAQAQTSTAAQPAATNAGATHASPSPFGPLKHVNAGLLNVAYAETGPADGPVVILLHGWPYDIHSYDEVAPLLAAKGYRVLMPYARGYGDTHFLSDKTLRNGQPAALASDVIDFMDALKIKQAVLGGYDWGARSAGIVSALWPERVKALVSVSGYLIGNQAAGKNPLPPKAELQWWYQFYFATDRGRAGYEKNTHDFARLIWQLASPQWAFDDATFERSAKALDNPDHVDITVFNYRWRLGLVQGESRYEALEQKLATAPAISVPTITLEGDANGAPHPAPEDYAKRFTGKYEFRLISGGIGHNLPQEDPQAFAKAVIDADHL
>NZ_CP014870.1|WP_064678488.1|4116155_4117241_-|AbrB-family-transcriptional-regulator
MSFLPRRLLHTPPVQWIALLLLAGAGGQLLKFLQVPAGEFLGPMLVAIGFGVCGASIRVHRHAFRLGQGAVGILAAHSMTLAVLTSLAQSWPMMLFATMLTVCLSALVGLAMVRLGGIPASTAAWGVAPGAASVMVSMSEDFGADSRVVATMQYVRVVCVVLIGALVSHWLGAPTGRSELHAASAVLPHFNLLDVVLTLATLLAGVALGNAIPAGALLMPLLLGAVLQMSGLLQITMPGWLLATAYGAIGCYVGLGFDRLTIRYVWRRMPAMILGAVVMIAVCALSAFLLAALLDKDFLSVYLATSPGGLDSMAIIAVDTHSDVGLVLAMQTLRLFVVLLTGAYLARLIIRLASRWEVVRT

Crispr_ID: NZ_CP014870_12

• CRISPR_ID: NZ_CP014870_12
• CRISPR_location: 4359145-4359237
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_12

Consensus_repeat	Method
ACGCGTTATCGTTGACGACCATCG	CRISPRCasFinder

spacers of NZ_CP014870_12

>12.1|4359169|45|NZ_CP014870|CRISPRCasFinder
CGAGCAAGCTCGCTCCTACATGGGCTCCGTGTTCAATCAGGACAT

CRISPR arrays and Neighbor proteins around NZ_CP014870_12

CRISPR arrays

The CRISPR arrays of NZ_CP014870_12

>merge|NZ_CP014870|12|4359145-4359237|CRISPRCasFinder
ACGCGTTATCGTTGACGACCATCGCGAGCAAGCTCGCTCCTACATGGGCTCCGTGTTCAATCAGGACATACGCGTTATCGTTGACGACCATCG

>NZ_CP014870|12|11|4359145-4359237|CRISPRCasFinder
ACGCGTTATCGTTGACGACCATCG	CGAGCAAGCTCGCTCCTACATGGGCTCCGTGTTCAATCAGGACAT
ACGCGTTATCGTTGACGACCATCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064678672.1|4356269_4357586_-|MFS-transporter	unknown	unknown	gnl|CDD|340877
NZ_CP014870.1|WP_191637734.1|4367030_4368044_-|GlxA-family-transcriptional-regulator	unknown	unknown	gnl|CDD|227311
NZ_CP014870.1|WP_064678666.1|4352032_4352755_+|DUF4198-domain-containing-protein	unknown	unknown	gnl|CDD|378467
NZ_CP014870.1|WP_064678682.1|4369164_4370013_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|226644
NZ_CP014870.1|WP_064678673.1|4357826_4359044_-|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl|CDD|226479
NZ_CP014870.1|WP_064678668.1|4353478_4353829_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064678670.1|4354618_4354783_+|DUF2986-domain-containing-protein	unknown	unknown	gnl|CDD|314517
NZ_CP014870.1|WP_064678679.1|4365690_4367007_+|L-fuconate-dehydratase	unknown	unknown	gnl|CDD|239440
NZ_CP014870.1|WP_064678678.1|4364641_4365589_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176126
NZ_CP014870.1|WP_064678677.1|4363677_4364640_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176126
NZ_CP014870.1|WP_064678675.1|4360355_4361936_-|aldehyde-dehydrogenase-(NADP(+))	unknown	unknown	gnl|CDD|143447
NZ_CP014870.1|WP_064678671.1|4355022_4356114_-|GlxA-family-transcriptional-regulator	unknown	unknown	gnl|CDD|227311
NZ_CP014870.1|WP_064678676.1|4361968_4363516_-|altronate-dehydratase	unknown	unknown	gnl|CDD|377287
NZ_CP014870.1|WP_064678669.1|4353934_4354609_+|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl|CDD|224996
NZ_CP014870.1|WP_064678665.1|4349344_4349704_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP014870.1|WP_064678683.1|4370009_4370858_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|226644
NZ_CP014870.1|WP_064678667.1|4352929_4353370_+|tryptophan-rich-sensory-protein	unknown	unknown	gnl|CDD|320706
NZ_CP014870.1|WP_064678681.1|4368152_4369151_-|4-hydroxyproline-epimerase	unknown	unknown	gnl|CDD|184428
NZ_CP014870.1|WP_193408114.1|4349926_4352017_+|TonB-dependent-siderophore-receptor	unknown	unknown	gnl|CDD|273805
NZ_CP014870.1|WP_064678674.1|4359283_4360339_-|Ldh-family-oxidoreductase	unknown	unknown	gnl|CDD|376860

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064678672.1|4356269_4357586_-|MFS-transporter	gnl|CDD|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	9.10876e-86
NZ_CP014870.1|WP_191637734.1|4367030_4368044_-|GlxA-family-transcriptional-regulator	gnl|CDD|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	8.54153e-96
NZ_CP014870.1|WP_064678666.1|4352032_4352755_+|DUF4198-domain-containing-protein	gnl|CDD|378467	pfam10670, DUF4198, Domain of unknown function (DUF4198). This family was previously missannotated in Pfam as NikM.	1.22227e-14
NZ_CP014870.1|WP_064678682.1|4369164_4370013_-|ABC-transporter-permease-subunit	gnl|CDD|226644	COG4176, ProW, ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism].	3.40867e-108
NZ_CP014870.1|WP_064678673.1|4357826_4359044_-|fumarylacetoacetate-hydrolase-family-protein	gnl|CDD|226479	COG3970, COG3970, Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only].	2.59051e-175
NZ_CP014870.1|WP_064678670.1|4354618_4354783_+|DUF2986-domain-containing-protein	gnl|CDD|314517	pfam11661, DUF2986, Protein of unknown function (DUF2986). This family of proteins has no known function.	2.86209e-05
NZ_CP014870.1|WP_064678679.1|4365690_4367007_+|L-fuconate-dehydratase	gnl|CDD|239440	cd03324, rTSbeta_L-fuconate_dehydratase, Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to mediate the down-regulation of thymidylate synthase protein by a novel intercellular signaling mechanism. A member of this family, from Xanthomonas, has been characterized to be a L-fuconate dehydratase. rTS beta belongs to the enolase superfamily of enzymes, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	0
NZ_CP014870.1|WP_064678678.1|4364641_4365589_-|LysR-family-transcriptional-regulator	gnl|CDD|176126	cd08435, PBP2_GbpR, The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold. Galactose-binding protein regulator (GbpR), a member of the LysR family of bacterial transcriptional regulators, regulates the expression of chromosomal virulence gene chvE. The chvE gene is involved in the uptake of specific sugars, in chemotaxis to these sugars, and in the VirA-VirG two-component signal transduction system. In the presence of an inducing sugar such as L-arabinose, D-fucose, or D-galactose, GbpR activates chvE expression, while in the absence of an inducing sugar, GbpR represses expression. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.00846e-55
NZ_CP014870.1|WP_064678677.1|4363677_4364640_-|LysR-family-transcriptional-regulator	gnl|CDD|176126	cd08435, PBP2_GbpR, The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold. Galactose-binding protein regulator (GbpR), a member of the LysR family of bacterial transcriptional regulators, regulates the expression of chromosomal virulence gene chvE. The chvE gene is involved in the uptake of specific sugars, in chemotaxis to these sugars, and in the VirA-VirG two-component signal transduction system. In the presence of an inducing sugar such as L-arabinose, D-fucose, or D-galactose, GbpR activates chvE expression, while in the absence of an inducing sugar, GbpR represses expression. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	8.48217e-54
NZ_CP014870.1|WP_064678675.1|4360355_4361936_-|aldehyde-dehydrogenase-(NADP(+))	gnl|CDD|143447	cd07129, ALDH_KGSADH, Alpha-Ketoglutaric Semialdehyde Dehydrogenase. Alpha-Ketoglutaric Semialdehyde (KGSA) Dehydrogenase (KGSADH, EC 1.2.1.26) catalyzes the NAD(P)+-dependent conversion of KGSA to alpha-ketoglutarate. This CD contains such sequences as those seen in Azospirillum brasilense, KGSADH-II (D-glucarate/D-galactarate-inducible) and KGSADH-III (hydroxy-L-proline-inducible). Both show similar high substrate specificity for KGSA and different coenzyme specificity; KGSADH-II is NAD+-dependent and KGSADH-III is NADP+-dependent. Also included in this CD is the NADP(+)-dependent aldehyde dehydrogenase from Vibrio harveyi which catalyzes the oxidation of long-chain aliphatic aldehydes to acids.	0
NZ_CP014870.1|WP_064678671.1|4355022_4356114_-|GlxA-family-transcriptional-regulator	gnl|CDD|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	1.59225e-139
NZ_CP014870.1|WP_064678676.1|4361968_4363516_-|altronate-dehydratase	gnl|CDD|377287	pfam04295, GD_AH_C, D-galactarate dehydratase / Altronate hydrolase, C-terminus. Family members include the C termini of D-galactarate dehydratase (EC:4.2.1.42) which is thought to catalyze the reaction D-galactarate = 5-keto-4-deoxy-D-glucarate + H2O, and altronate hydrolase (altronic acid hydratase, EC:4.2.1.7), which catalyzes D-altronate = 2-keto-2-deoxygluconate + H2O. As purified, both enzymes are catalytically inactive in the absence of added Fe2+, Mn2+, and beta-mercaptoethanol. Synergistic activation of altronate hydrolase activity is seen in the presence of both iron and manganese ions, suggesting that the enzyme may have two ion binding sites. Mn2+ appears to be part of the enzyme active centre, but the function of the single bound Fe2+ ion is unknown. The hydratase has no Fe-S core.	0
NZ_CP014870.1|WP_064678669.1|4353934_4354609_+|NAD(P)-binding-domain-containing-protein	gnl|CDD|224996	COG2085, COG2085, Predicted dinucleotide-binding enzymes [General function prediction only].	1.39257e-40
NZ_CP014870.1|WP_064678683.1|4370009_4370858_-|ABC-transporter-permease-subunit	gnl|CDD|226644	COG4176, ProW, ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism].	1.12228e-106
NZ_CP014870.1|WP_064678667.1|4352929_4353370_+|tryptophan-rich-sensory-protein	gnl|CDD|320706	cd15904, TSPO_MBR, Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family. This family contains tryptophan-rich translocator protein (TSPO), an integral membrane protein that is highly conserved from bacteria to mammals. In eukaryotes, it is mainly found in the outer mitochondrial membranes of steroid-synthesizing cells of the nervous system where it transports cholesterol into mitochondria. It is known to be highly expressed in metastatic cancer, steriodogenic tissues, as well as inflammatory and neurological diseases such as Alzheimer's and Parkinson's. TSPO is also known as the peripheral benzodiazepine receptor (MBR) and its ligands include benzodiazepine drugs, implicated in regulating apoptosis. In human, a single polymorphism A147T is associated with psychiatric disorders; the mutation causes structural changes in a region implicated in cholesterol binding. TSPO is homologous to bacterial tryptophan-rich sensory proteins, and their tryptophan residues are believed to be functionally important. In bacteria, TSPO acts as a negative regulator of expression of specific photosynthesis genes in response to oxygen/light; it catalyzes a photooxidative degradation of Proto porphyrine (PpIX). R. sphaeroides TSPO (RsTSPO) is involved in porphyrin transport, similar to human, while Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.	8.35312e-35
NZ_CP014870.1|WP_064678681.1|4368152_4369151_-|4-hydroxyproline-epimerase	gnl|CDD|184428	PRK13971, PRK13971, 4-hydroxyproline epimerase.	0
NZ_CP014870.1|WP_193408114.1|4349926_4352017_+|TonB-dependent-siderophore-receptor	gnl|CDD|273805	TIGR01783, Ferrienterobactin_receptor, TonB-dependent siderophore receptor. This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	2.30688e-95
NZ_CP014870.1|WP_064678674.1|4359283_4360339_-|Ldh-family-oxidoreductase	gnl|CDD|376860	pfam02615, Ldh_2, Malate/L-lactate dehydrogenase. This family consists of bacterial and archaeal Malate/L-lactate dehydrogenase. L-lactate dehydrogenase, EC:1.1.1.27, catalyzes the reaction (S)-lactate + NAD(+) <=> pyruvate + NADH. Malate dehydrogenase, EC:1.1.1.37 and EC:1.1.1.82, catalyzes the reactions: (S)-malate + NAD(+) <=> oxaloacetate + NADH, and (S)-malate + NADP(+) <=> oxaloacetate + NADPH respectively.	8.07136e-93

Protein sequences

>NZ_CP014870.1|WP_064678673.1|4357826_4359044_-|fumarylacetoacetate-hydrolase-family-protein
MTNESTTQAPLPLSSNPAVFNTGSWVGRVWLPGQGPAVVLVKAGAVHDISAHVATVSALLEVADPVKYLRALPLAEALIELPALLDNSDPNQRDENLPWLLAPIDLQAVKAAGVTFAASLLERVVEEQAKGDPAKADAIRDTLASRIGADLSQIVPGSAQAEALRKVLVEQGLWSQYLEVGIGPDAEIFTKAQPLSAVGHGADIGIHPKSSWNNPEPEVVLAVSSNGTLQGAMLGNDVNLRDFEGRSALLLSKAKDNNASTSLGPLLRLFDETFSLDDVRNAEVDLRVEGQDGFIMEGRSSMRQISRDPLDLVQQTLNENHQYPDGLVLFLGTLFAPKQDRDQPGNGFTHKPGDLVAISNAQLGTLCNRVTTSDQAPRWDFGLRSLIDSLSRRGLLEAAVTARQP
>NZ_CP014870.1|WP_064678672.1|4356269_4357586_-|MFS-transporter
MKPLKKYQSITVVFLLLIGIVNYLDRSALSIANTSIQKDMMISPSQMGILLSAFSIAYAFAQLPMGMIIDRLGSKIALGASLLAWSVAQSTFGMVNSFAGFMGLRVLLGIGEAPMFPSAAKALSEWFDANERGTPTGIVWSSTCIGPCLAPPLLTLFMVNFGWRGMFIITGAIGIVLAVCWLAFYKSKAQYLAELAAEGKPLPTEKTAPVQAVDPQAPKVSYFAGWLDLFKHRSTWGAVLGFMGVIYMLWLHLTWLPGYFEREHGMNLYKTAWLVSLAYGFGAVGTIVAGRFCDRLVRRGMSILASRKFGVITGLVLAALFTVPLSFVTGLTGCIILLCLALFSINMASATAWMIVNTIVDSRRVASFGSIQNFGGYIAGSVAPIVTGFSIQYSGSFNTAFMISAVVALCSALAYYLLLNAPISDAEPAPEHIVGVTE
>NZ_CP014870.1|WP_064678671.1|4355022_4356114_-|GlxA-family-transcriptional-regulator
MAYDTPRAVPPQTIGFLLLDQFTLISLASAVEPLRMANQLTGQELYRWHTFTLGGAQVWASDGMPITPDSSIDDALLLDTVIVCGGTGIQSAVTRDHIIWLRTQARRTKRMGGVCTGSWALAQAGLLDGFDCSVHWEFLAAMQEAFPRVNLSSSLFTLDRDRFTSSGGTAPMDMMLHLISRDHGHELSAAISDMFVYERIRNEQDHQRVPLKHMLGTHQPKLQEIVALMEANLEEPIDLDELANYVGLSRRQLERLFQKYLKSSPSRYYLKLRLIRARQLLKQTSISIVELSVVCGFVSTPHFSKCYRECFGIPPSDERLVAQTQPQVTARAVEQASPSARQVSLLEQARDESTFASIKIVKS
>NZ_CP014870.1|WP_064678670.1|4354618_4354783_+|DUF2986-domain-containing-protein
MNRQKKIKQLLKAHAKKASAKLAPANKSKYISKADRLKLAAESSDDSISSSENA
>NZ_CP014870.1|WP_064678669.1|4353934_4354609_+|NAD(P)-binding-domain-containing-protein
MPKILFLMFASLVLCTSQAMADALKISVIGAGKVGGTLGTLWVKAGHSVMFSSRHPEELTDLVKSAGPNARAGSVSDAAAWGDVIVLSVPYGAMPVLSEQLKGKLDGKVVFSTSNPFSGRDGDVGRKALDEGVALADQQYLPGVHLVRAFNAISYTSMKDQAGKGKAIPVFADDSQARELGARLVRDSGFVPVIFPLARAKDGLPNGPLSGVWNEADLKRKQTN
>NZ_CP014870.1|WP_064678668.1|4353478_4353829_+|hypothetical-protein
MNEELTEEEMRRALFGDPEPVEQASDLPEEETVPDIVIAPPEKPEKPVKVAEKKKISKAFTPRLRVTLRVGNEFEGKMHEMIHEADTLSTLLAEQEATKAARKKFRFVEVVSVKPM
>NZ_CP014870.1|WP_064678667.1|4352929_4353370_+|tryptophan-rich-sensory-protein
MTFLIFLLACGAAASTGILFKPGQWYDSLVKPDFTPPNWLFPVAWSIIYLLLAWAGYRLTLIPGSQVVLALWAAQIALNTLWTPVFFGAHHIFAGMVILALLWLVVAAMVVMAMQLDVITGLILFPYLVWLCVAAALNFSILRNNR
>NZ_CP014870.1|WP_064678666.1|4352032_4352755_+|DUF4198-domain-containing-protein
MHSSLKIAAALALVITAQASAHGLWTEERRGNIEVVYGHGAEDGPFKAEKIKGGWAFDAAGKMIPVTVQRLADHARLQPLRPPAIMAVLLDNGPWSQTPDKRWVNQDRTQVQDAIASTHSFKYSLAIYQEGARLPKLDMLRLAIIPQSDPLKVGPGKELQVQVLIDGRPAADIELYGDYRGAPHEISGKTDKGGRARIKVRNEGLNIIAAQLTLPMPKGAPVDKQSLFSSLTFVGEPHHE
>NZ_CP014870.1|WP_193408114.1|4349926_4352017_+|TonB-dependent-siderophore-receptor
MKHYAPLLAGLTLGLFEQPLSAAETLVLDELSITDSLIEERADGPVRGYRATRSATATRTDTDIRDTPQSIDVIPAQVIQDLNTSRIDRALDFAGGVARQNNFGGLTFLNYSVRGFTTGELYKNGFAINRGSYSSPDTSSIERIEVLKGPAASLYGRGDPGGLVNIVTKRPQPEAFSTLSVSAGTWDRYRSNLDVNAPLDSEGNLLGRVNLAVEDNGSFRDHVGNERRIVSPSLSWQISPDTRLMLDTEFSRTESVFDRGIPAVNGELGSVKRSTFLGEPNDGQIRNDNQTIDLALEHYLNDDWKLRLANHYTQGTLKGASSEPQALVGTTISRFYRERDFEWNDSITQAELHGHFELGGWQHQTLTGLEYENYRNSQKYPQSATLLSYGLDIYNPVYGQPKPALTRANDFFEHTESYALNLQDQIAFTERLRGLIGVRLERIEQTSLNRTTGVSNSQEKDVATPRIGLLYQLTPQVGVFANASTSFKPNTVGTQGQVYKPEKGLGYESGLKLDLFDSRIGATVALFHIDKENVITTDALGDSVAAGKARSQGLDLQFSGQVTDALRVIGAYAYIDAEVTKGDAAIPEGSDLLGIARHSGSLMAVHAFQNGALRGSDIGAAVSYVGERSGQTGSAFTLPSYSTVDLLAHYQASEEVTVGLNLNNLFNRKYYERAYNSAWVMPGDPRNLSVSLTLNL
>NZ_CP014870.1|WP_064678665.1|4349344_4349704_+|hypothetical-protein
MFKVTPNPPDTDPVSPYEPDSNTLNETAERTLDFHSPSTADIKATPRTPSTLFTIDPQATTETLAVYLVETLASVDVMVHHLVDHLDGGSRNALLGISNSIMLAEITANRMLDQIDPSA
>NZ_CP014870.1|WP_064678674.1|4359283_4360339_-|Ldh-family-oxidoreductase
MTEGKRYDAQTLTTFVEQLFETAGADAEVAQVVTRVLLEGELLGHRTHGLNLVSRYIGGMLTGQVKASAGLLEQVSDSGISTLFDGHYVLGPYCVSRALDSAAKGATEQGIGIAVVRRASHIGCLAAYLKPFTDRGLVAMVYSSDPSVGLVCAHGGIDPIYTPNPIAAGIPTRGEPILLDVSMSTVTLGLVGQCREAGSPLPHPVLMSNKGQVTDDPADFFTTPPGSILPLGGQAFGHKGFALAILVEALTSGLAGHGRKDAPDQWGASATAVVIDPRFFGGLDAFTDESSFLSKLILASRPVDPERPVRLPGQAGLKLREQALREGVSLAQKVVDDLNQTAGQLQLPALS
>NZ_CP014870.1|WP_064678675.1|4360355_4361936_-|aldehyde-dehydrogenase-(NADP(+))
MQVSGFNFIAGQRSALGDTLVYSVDAHTGERLPGAFHQATLAEVDTAVAAASAAFPLYRNLPAVRRAEFLEAIADELDGLGEDFIALTCQETALPSARIQGERGRTSGQMRLFAQVLRRGDFYGARIDQALPARTPMPRPDLRQYRIGVGPVAVFGASNFPLAFSTAGGDTAAALAAGCPVVFKAHSGHMATAERVAEALIRAAERTGMPAGVFNMIFGAGVGEALVKHPGIQAVGFTGSLKGGRALCDMAAARPQPIPVFAEMSSINPVLVLPQALASRGAQMAKELTASVVQGCGQFCTNPGLVLGIRSPAFSAFIEQLTGHMAEQTPQTMLNPGTLNSYGKGLQALLAHPGIKHLSGLAQAGNQAQPQLFEADVSLLLEQDELLQEEVFGPCTVVVQVADEAELRRAVAALRGQLTATLLADNDDLTTFGQLFSALEVKVGRVLLNGYPTGVEVCDAMVHGGPYPATSDARGTSVGTLAIDRFLRPVCYQNVPDALLPDALKNANPLGLQRLVDGKSSTAALN
>NZ_CP014870.1|WP_064678676.1|4361968_4363516_-|altronate-dehydratase
MQLIARTRTGDPAVIRLNPLDNVLIARQALPEGLSLEAEAVTVRQPIPSGHKVASQRVEQGQPLRRYGQIIGFASQPIEAGDHVHVHNVEMGDFARDYAFGVDTHATPGTEAVFQGIVRADGRVATRNYVGILTSVNCSATVARAVADHFRRDIHPEALAAFPNIDGVVALTHGAGCAVDPNGEALGLLRRTLGGYAVHPNFAAVLIIGLGCETNQIESLLETQGLTASDQLRAFTIQGIGGTSKTIASGIEQVKALLPKANHVQREPVSARHLIVGLQCGGSDGYSGITANPALGNAVDRLVAAGGTAILSETPEIYGAEHLLTRRAVSREVGEKLIARIHWWEDYCQRMNAELNNNPSAGNKAGGLTTILEKSLGAVAKAGSSNLVDVYLYAEAVRAKGLVFMDTPGYDPVSATGQVAGGANLIAFTTGRGSAYGCAPAPSIKLATNNRVFEHQEEDMDVNCGGIADGSTSIEERGAYIFEQMLRIASGERSKSEQHGYGQNEFVPWQIGAVT
>NZ_CP014870.1|WP_064678677.1|4363677_4364640_-|LysR-family-transcriptional-regulator
MPSDITHSSFCNWVRFKHLVLIDTLARTRNMHATAIRMNLSQPALSKMLRDLEEQFGFALFQRLPRSMPPTELGEHVVRYAQSALADSHKFVDQVNRLRKGGHGFLKVGGIFAATSVVLPQAIVAIKARSPLLSIEVVEQSSDHLLEMLEQNKLDLMIGRFTEERYSQVFDFEPLEPEPFSLVVNSSHPLNELDCTPLEALGQWPWVLYPVGTPIRDRLELAFKAAGIASPADSVETISMQMFLQLLHSGPMIAMLPRSMVAAQLDSGQFKELQTPLRLAQLEYGIITRKDEPLTGAAREFADILLDFARERREEGAPSD
>NZ_CP014870.1|WP_064678678.1|4364641_4365589_-|LysR-family-transcriptional-regulator
MSTGPAATTIPPHGLGALKISSRQITLLTALGEFGNLRRAATAMHTTQPAASLLLQQLEERLGVRLFERLPRGMQPTLYGEVMIRYAQGALHEFEQAQAQIAELQRGALGRVRVGSVMGPVPRLLTKAVLAYKRDHPKVRISIEVGTSDTLLPALLRGDFDVVLGRLPDQSDSQDLDIELFDNGEQMRVVARAGHPLAGASSLQLADLITLTWILHPIGSPMRRRVETALQAAGMVQSLDIVETASILATTAMLEASDMIAVVPNDVAEHYARYGMVAVLPVELPISMVNIGLLTVRSRSRSVALNTLLDYFREP
>NZ_CP014870.1|WP_064678679.1|4365690_4367007_+|L-fuconate-dehydratase
MSIRITQLSVRDIRFPTSLSLDGSDAMNSAPDYSASYVVLHTDAPGGLEGHGLTFTIGRGNEICVAAVQSLAPMVVGLTLEEIVADMGAFWHTITVGDSQLRWLGPEKGVIHLATAAIVNAIWDLWAKNEGKPVWKLLADMTPEQVVRCLDFSYVTDVLTPEEAIALLRRQVPGKAQREAQMLREGYPGYTTAPGWLGYSEDKMRQLAREAVEDGWTHIKQKIGANLEDDIRRATILREEIGWERTLMMDANQVWGVDESVANMRRLAAFEPLWIEEPTSPDDILGHASIRQRIAPIGVASGEHCHNRVMFKQMFQAGALDFCQLDAARLGGLNEVLIVLLMAAKFNVPVCPHGGGVGLCEYVQNIALFDYIAVSASLHNRVLEYVDHLHEHFLDPVVIRRGRYMPPQRAGYSIEMTAETLERYQYPGGQVWLDIART
>NZ_CP014870.1|WP_191637734.1|4367030_4368044_-|GlxA-family-transcriptional-regulator
MIERRQFSGGMKGKNLRYLNENPGQPAQMTRAGFLLLEHFSLPAFTQALDTIVTSNLLRPGLFSSRTFGLSDAEVVSDLGLVIRPDARLDSAAIHDLDLLVICGGYRTELKASDEFINLLRAATDQGVTLAGLWNGAWFLGRAGLLDGYRCAIHPEHRPALAEIAKATQVSSEPYVIDRDRLTASSPSGAFHMALDWIKGLHDKALVEGIEDILAFEESRYRRIKPTENICVSAPLREVVKLMDANLEEPLELEQLAVYAGRSRRQLERLFKEQLGTTPQRYYMELRITEARRLLQHTELSQVDVLVACGFVSPSHFSKCYSSYFGYRPSKEKRLVK
>NZ_CP014870.1|WP_064678681.1|4368152_4369151_-|4-hydroxyproline-epimerase
MRRSFFCIDSHACGNPVRVVAGGGPLLPSVSMAERREIFVRDHDWVRTALMFEPRGHDIMSGVIIYPSVRDDCDFGALFIEVSGCLPMCGAGTIGLSTVVIEEGLITPREPGKLAIETPAGRVDVDYSMNGEYVDSIRLFNVASYLHSADVVVDVPGVGELVVDIAYGGNFYAVVEPQENWSGLDGLTTAEIVGLSQKLRTALAEVCDPVHPENSRISGVHHVIWCDDQHSTAAHGRGAVFYGDKAIDRSPGGTGTSARMAQLVGKGRLKVGDTYRNESLIGTIFEGKVEAAVKVGTFDGIRPSIGGWAQITGHNTIFVDDRDPLRHGFQLA
>NZ_CP014870.1|WP_064678682.1|4369164_4370013_-|ABC-transporter-permease-subunit
MSTPIQFSPGEYLAPGVDWLNANLHGLFRGISRVIEAVLGAVEGTLLAPHPYLFIAIVVVAAFFFANKRVAIFAGLMLAFCLFSGLWAASMQTIALVSVAVLISVTIAFPLGVLAARVKRVDDAFLPILNIMQTVPPWVYLIPAVMLFSLGKVPAIIATIVYGIPPMLRLTTLAFKQLPKDLLELGQASGASPRDILFKIELPTAAPTLLVGLNQCILMSLAMVVLAGLVGAGGLGAEVTRGLSRMEMGLGLRAGLAIVAVALLLDRLSRGALQRHSPTTMV
>NZ_CP014870.1|WP_064678683.1|4370009_4370858_-|ABC-transporter-permease-subunit
MSTPDFSNQFDAVVDSSLEWLSDNGEFLFDGINAMLTGLYEGVLWCLAYPPYYLVALAIALIGWRVVGVRFAILTGLALVFCDIIGLWPETVSTLALVLTATVLALVVAIPLGVLAGLAPSVDRVVDPVLDLIQTMPPYIYLLPAIALLGYGPATALLATFIVAVPPAIRLTSLGIRMTPKHFIELGDASGVTNWQMFFKIRLPFAKPSIMAGVNQSLMMAFGMVVIAGIVGSGGLGESIYAAVRTLDIAKSINAAISIVILTMILDRLAQHAARSRTGESQ

Crispr_ID: NZ_CP014870_13

• CRISPR_ID: NZ_CP014870_13
• CRISPR_location: 4436795-4436895
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_13

Consensus_repeat	Method
ATTACAGATACACCGCGGTGCCTGGTTCGC	CRISPRCasFinder

spacers of NZ_CP014870_13

>13.1|4436825|41|NZ_CP014870|CRISPRCasFinder
CTGTAGGAGCCAGGCTTGCCGGCGAAGAACGGTAACGCGGC

CRISPR arrays and Neighbor proteins around NZ_CP014870_13

CRISPR arrays

The CRISPR arrays of NZ_CP014870_13

>merge|NZ_CP014870|13|4436795-4436895|CRISPRCasFinder
ATTACAGATACACCGCGGTGCCTGGTTCGCCTGTAGGAGCCAGGCTTGCCGGCGAAGAACGGTAACGCGGCATTACAGATACACCGCGGTGCCTGGTTCGC

>NZ_CP014870|13|12|4436795-4436895|CRISPRCasFinder
ATTACAGATACACCGCGGTGCCTGGTTCGC	CTGTAGGAGCCAGGCTTGCCGGCGAAGAACGGTAACGCGGC
ATTACAGATACACCGCGGTGCCTGGTTCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064678744.1|4441564_4443349_+|NADH-quinone-oxidoreductase-subunit-C/D	unknown	unknown	gnl|CDD|236965
NZ_CP014870.1|WP_064678745.1|4443845_4445201_+|NADH-quinone-oxidoreductase-subunit-NuoF	unknown	unknown	gnl|CDD|236891
NZ_CP014870.1|WP_007905076.1|4449624_4450128_+|NADH-quinone-oxidoreductase-subunit-J	unknown	unknown	gnl|CDD|235844
NZ_CP014870.1|WP_064678735.1|4425836_4428062_+|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl|CDD|377178
NZ_CP014870.1|WP_064678739.1|4430650_4432021_+|adenylosuccinate-lyase	unknown	unknown	gnl|CDD|236452
NZ_CP014870.1|WP_064678740.1|4432107_4433277_+|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|225406
NZ_CP014870.1|WP_064678738.1|4429900_4430524_+|high-frequency-lysogenization-protein-HflD	unknown	unknown	gnl|CDD|234690
NZ_CP014870.1|WP_064678736.1|4428252_4428699_+|NUDIX-hydrolase	unknown	unknown	gnl|CDD|239647
NZ_CP014870.1|WP_064678741.1|4433269_4433695_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379326
NZ_CP014870.1|WP_008032724.1|4435311_4436637_+|isocitrate-lyase	unknown	unknown	gnl|CDD|237893
NZ_CP014870.1|WP_064678742.1|4434076_4434838_+|secretin	unknown	unknown	gnl|CDD|333965
NZ_CP014870.1|WP_052967023.1|4449066_4449615_+|NADH-quinone-oxidoreductase-subunit-NuoI	unknown	unknown	gnl|CDD|235637
NZ_CP014870.1|WP_008146039.1|4443351_4443849_+|NADH-quinone-oxidoreductase-subunit-NuoE	unknown	unknown	gnl|CDD|181024
NZ_CP014870.1|WP_050682721.1|4440817_4441492_+|NADH-quinone-oxidoreductase-subunit-B	unknown	unknown	gnl|CDD|223454
NZ_CP014870.1|WP_003223812.1|4440393_4440807_+|NADH-quinone-oxidoreductase-subunit-A	unknown	unknown	gnl|CDD|180638
NZ_CP014870.1|WP_010458895.1|4424083_4425340_-|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl|CDD|180792
NZ_CP014870.1|WP_064678746.1|4445338_4448053_+|NADH-quinone-oxidoreductase-subunit-NuoG	unknown	unknown	gnl|CDD|236170
NZ_CP014870.1|WP_064678737.1|4428758_4429904_+|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl|CDD|234664
NZ_CP014870.1|WP_064678747.1|4448049_4449057_+|NADH-quinone-oxidoreductase-subunit-NuoH	unknown	unknown	gnl|CDD|235692
NZ_CP014870.1|WP_064678743.1|4436948_4439540_-|leucine--tRNA-ligase	unknown	unknown	gnl|CDD|234743

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064678744.1|4441564_4443349_+|NADH-quinone-oxidoreductase-subunit-C/D	gnl|CDD|236965	PRK11742, PRK11742, bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional.	0
NZ_CP014870.1|WP_064678745.1|4443845_4445201_+|NADH-quinone-oxidoreductase-subunit-NuoF	gnl|CDD|236891	PRK11278, PRK11278, NADH-quinone oxidoreductase subunit NuoF.	0
NZ_CP014870.1|WP_007905076.1|4449624_4450128_+|NADH-quinone-oxidoreductase-subunit-J	gnl|CDD|235844	PRK06638, PRK06638, NADH-quinone oxidoreductase subunit J.	1.53592e-53
NZ_CP014870.1|WP_064678735.1|4425836_4428062_+|NADP-dependent-isocitrate-dehydrogenase	gnl|CDD|377178	pfam03971, IDH, Monomeric isocitrate dehydrogenase. NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism, as it controls the carbon flux within the citric acid cycle and supplies the cell with 2-oxoglutarate EC:1.1.1.42 and NADPH for biosynthetic purposes.	0
NZ_CP014870.1|WP_064678739.1|4430650_4432021_+|adenylosuccinate-lyase	gnl|CDD|236452	PRK09285, PRK09285, adenylosuccinate lyase; Provisional.	0
NZ_CP014870.1|WP_064678740.1|4432107_4433277_+|cupin-domain-containing-protein	gnl|CDD|225406	COG2850, COG2850, Uncharacterized conserved protein [Function unknown].	1.13894e-149
NZ_CP014870.1|WP_064678738.1|4429900_4430524_+|high-frequency-lysogenization-protein-HflD	gnl|CDD|234690	PRK00218, PRK00218, lysogenization regulator HflD.	5.69179e-98
NZ_CP014870.1|WP_064678736.1|4428252_4428699_+|NUDIX-hydrolase	gnl|CDD|239647	cd03675, Nudix_Hydrolase_2, Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.2544e-73
NZ_CP014870.1|WP_064678741.1|4433269_4433695_+|GNAT-family-N-acetyltransferase	gnl|CDD|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.48702e-23
NZ_CP014870.1|WP_008032724.1|4435311_4436637_+|isocitrate-lyase	gnl|CDD|237893	PRK15063, PRK15063, isocitrate lyase; Provisional.	0
NZ_CP014870.1|WP_064678742.1|4434076_4434838_+|secretin	gnl|CDD|333965	pfam00263, Secretin, Bacterial type II and III secretion system protein.	2.78907e-07
NZ_CP014870.1|WP_052967023.1|4449066_4449615_+|NADH-quinone-oxidoreductase-subunit-NuoI	gnl|CDD|235637	PRK05888, PRK05888, NADH-quinone oxidoreductase subunit NuoI.	5.10357e-78
NZ_CP014870.1|WP_008146039.1|4443351_4443849_+|NADH-quinone-oxidoreductase-subunit-NuoE	gnl|CDD|181024	PRK07539, PRK07539, NADH-quinone oxidoreductase subunit NuoE.	1.73642e-92
NZ_CP014870.1|WP_050682721.1|4440817_4441492_+|NADH-quinone-oxidoreductase-subunit-B	gnl|CDD|223454	COG0377, NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion].	1.61471e-102
NZ_CP014870.1|WP_003223812.1|4440393_4440807_+|NADH-quinone-oxidoreductase-subunit-A	gnl|CDD|180638	PRK06602, PRK06602, NADH:ubiquinone oxidoreductase subunit A; Validated.	1.18003e-57
NZ_CP014870.1|WP_010458895.1|4424083_4425340_-|NADP-dependent-isocitrate-dehydrogenase	gnl|CDD|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0
NZ_CP014870.1|WP_064678746.1|4445338_4448053_+|NADH-quinone-oxidoreductase-subunit-NuoG	gnl|CDD|236170	PRK08166, PRK08166, NADH-quinone oxidoreductase subunit NuoG.	0
NZ_CP014870.1|WP_064678737.1|4428758_4429904_+|tRNA-2-thiouridine(34)-synthase-MnmA	gnl|CDD|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP014870.1|WP_064678747.1|4448049_4449057_+|NADH-quinone-oxidoreductase-subunit-NuoH	gnl|CDD|235692	PRK06076, PRK06076, NADH-quinone oxidoreductase subunit NuoH.	3.25673e-159
NZ_CP014870.1|WP_064678743.1|4436948_4439540_-|leucine--tRNA-ligase	gnl|CDD|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0

Protein sequences

>NZ_CP014870.1|WP_008032724.1|4435311_4436637_+|isocitrate-lyase
MALTREQQIAALEKDWAENPRWKGVTRAYSAADVVRLRGSVQPEHTFAKLGAEKLWNLVTQGAKPSFRPEKDFVNCMGALTGGQAVQQVKAGIQAIYLSGWQVAADNNSAESMYPDQSLYPVDSVPTVVKRINNSFRRADQIQWKAGKGPGDEGYIDYFAPIVADAEAGFGGVLNAYELMKSMIEAGAAGVHFEDQLASVKKCGHMGGKVLVPTQEAVQKLTAARLAADVAGTPTIILARTDANAADLLTSDCDPYDQPFVTGERTQEGFYKVRAGLDQAIARGLAYAPYADLIWCETAKPDLDEARRFAEAIKKEYPDQLLSYNCSPSFNWKKNLDDATIAKFQRELSAMGYKHQFITLAGIHNMWHSMFNLAHDYARNDMTAYVKLQEQEFADAAKGYTFVAHQQEVGTGYFDDMTTVIQGGSSSVTALTGSTEEEQFH
>NZ_CP014870.1|WP_064678742.1|4434076_4434838_+|secretin
MSLRTLLTTLLLTCSASVMAATEIVPLNYHTSADMLPMAQDFIGKEGQVSAYGNQLIVNADQRKIDELKALIAQLDTAPKRLLITVDTSENNFQNDQGYSVNGAKPGQTRIISRSTDSRDGGIQQIQASEGAPALIQVGQSVPLTSTQADSYGDLRSQTEYRNVTQGFYVTASVTGETVHLAISTNRDRISQERPDVVNVQSTDTTVTGRLGEWITLAGVNRQTQADKQGLTRSYSTQGRDDMTLRVKVDTLD
>NZ_CP014870.1|WP_064678741.1|4433269_4433695_+|GNAT-family-N-acetyltransferase
MNKIHVRVADWQKDNAEIRRIRETVFVAEQSVPPELEWDADDVTAVHFLALEGDFPVGTARLLHDGHVGRVSVLKDWRGLKVGDALMHAVIGEAEQRGLKQQMLSAQVQATAFYERLGFHMVSEEFLEAGIPHVDMVRHSA
>NZ_CP014870.1|WP_064678740.1|4432107_4433277_+|cupin-domain-containing-protein
MNPDIPLQLLGGITAREFLRDYWQKKPLLIRQAIPEFESPIDADELAGLALEEEVESRLIIENGERPWELRRGPFAEDEFSKLPERDWTLLVQAVDQFVPEVAELLENFRFLPSWRIDDVMISFAAPGGSVGPHFDNYDVFLLQGHGKRNWKIGQMCDSESKLLQHADLRILADFEATDEWVLEPGDMLYLPPRLAHCGVAVDDCLTYSVGFRAPSAAEVLTHFTDFLSQFLPDEDRYTDADALPSADPHQIQHDALDRLKGLLAEHMSDERLLLTWFGQFMTEPRYPELVVGPEEIEEDDLLASLEQGAVLIRNPSARLAWSEVDDDLLLFASGQSRYLPGKLRELLKMICAADSLHVDNLGDWLSDEDGRGLLCELIKQGSLGFADE
>NZ_CP014870.1|WP_064678739.1|4430650_4432021_+|adenylosuccinate-lyase
MQLSSLTAVSPVDGRYAGRTQALRPIFSEYGLIRARVLVEVRWLQRLAAHPGISEVPAFSAEANAVLNTLADNFALEHAERVKEIERTTNHDVKAIEYLLKEQAAKLPELAKVSEFIHFACTSEDINNLSHALMLREGRDDVMLPLMRQTADAIRELAIRFADVPMLSRTHGQPASPTTLGKELANVVYRLERQIAQVAAVPLLGKINGAVGNYNAHLSAYPEIDWEENARAFIEDELGLGFNPYTTQIEPHDYIAELFDAIARFNTILIDFDRDIWGYISLGYFKQRTIAGEIGSSTMPHKVNPIDFENSEGNLGIANALFQHLASKLPISRWQRDLTDSTVLRNLGVGFAHSVIAYEASLKGISKLELNAQKIAADLDACWEVLAEPIQTVMRRYNIENPYEKLKELTRGKGISPEALQTFIDGLDMPAAAKAELKLLTPANYIGNAVEQARRI
>NZ_CP014870.1|WP_064678738.1|4429900_4430524_+|high-frequency-lysogenization-protein-HflD
MNPTQEQLTALGGVFLAAVLVDKIAKTGQTTEAGLTCMLGSLLIRDPKDTLEVYGGDDLNLREGYRALIGALERDPSTLQREPLRYALAMLGLERQLAKRGDMLDEIGKRLPQIQSQVEHFGAAHENVIAACGALYQDTLSTLRQRIQVHGDMRNLQQPSNASKIRALLLAGIRSARLWRQLGGHRWQLVISRRKLLKELYPLMRSS
>NZ_CP014870.1|WP_064678737.1|4428758_4429904_+|tRNA-2-thiouridine(34)-synthase-MnmA
MRDPAPSDTQKKRVIVGMSGGVDSSVSALLLIEQGYEVEGLFMKNWEEDDGTEYCTAMDDLADAQAVCDRIGIKLHTANFAAEYWDNVFEHFLAEYKAGRTPNPDILCNREIKFKAFLDYAMMLGADLIATGHYVRRRDIDGRTELLKGLDPNKDQSYFLHAVGGEQIAKTLFPVGELEKPEVRAIAEKHQLATAKKKDSTGICFIGERRFSDFLKQYLPAQPGEIKTTEGEVIGRHHGLMYHTIGQRQGLGIGGLKDASDEPWYVLIKDLEHNELIVGQGNDHPYLFSRALLASEIYWVNPIDLSEPRKLTAKVRYRQSDQPCTLEKTASGYRATFDDPQRAVTPGQSVVFYDGEICLGGGVIEIAEPWTSKSTSKGQAQ
>NZ_CP014870.1|WP_064678736.1|4428252_4428699_+|NUDIX-hydrolase
MDWLPHITVATIVEDNGRFLMVEETKHGRTVLNQPAGHLDPDETLIEAAVRETLEETGWDVEPTGVVGIYLYTAPSNGVTYQRVCFNAKPLKHHPDYQLDDGIVGAKWLTRDELLAQRANWRSELIIRCIDDYLDGNHFGLELIRPSL
>NZ_CP014870.1|WP_064678735.1|4425836_4428062_+|NADP-dependent-isocitrate-dehydrogenase
MPTRSKIIYTFTDEAPALATYSLLPIVEAFTASADIAVETRDISLAGRILASFPEQLGDKAVADHLAELGDLAVTPEANIIKLPNISASVPQLQAAIKELQAQGFALPDYPETVTSDADKLAKSRYDKIKGSAVNPVLREGNSDRRAPLSVKNYARKHPHKMGAWAADSKSHIAHMSTGDFYGSEKAALIDAADAVKIELIAQDGTTTVLKEKTTVQAGEILDCAVMSKNALRRFIAAEIEDAKAKGVLLSVHLKATMMKVSDPIMFGQIVAEFYKDALAKHADVLAQIGFNLNNGIGDLYARIKALPSDQQAQIEADIQAVYADRPSLAMVNSDKGITNLHVPSDVIVDASMPAMIRDSGKMWGTDGQLHDTKAVIPDRCYATIYQAVIEDCKLHGAFDPTTMGSVPNVGLMAKKAEEYGSHDKTFQIKTNGVVRVTDSKGGLLLEQSVEAGDIFRMCQTKDAPIQDWVKLAVNRARASSTPAIFWLDPMRAHDGVVIEKVQAYLKDHDTAGLDIQIMAPVDAMKFTLQRTREGKDTISVTGNVLRDYLTDLFPIMELGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQLLEENFLRWDSLGEFLALAASLEHLGVTYNNPKALVLAKTLDQATGQFLDNNKSPSRKVGNIDNRGSHFYLALYWAQALAAQSEDTALQAQFGELAKTLTENEATIVAELNAVQGKPVDIGGYYHANAELISKAMRPSNTFNAAIAALV
>NZ_CP014870.1|WP_010458895.1|4424083_4425340_-|NADP-dependent-isocitrate-dehydrogenase
MGYKKIQVPAVGDKITVNADHSLNVPNNPIIPFIEGDGIGVDISPVMIKVVDAAVKKAYGGERKISWMEVYAGEKATQVYDQDTWLPQETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPSPVKKPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLKDEMGVTKIRFDENCGIGIKPVSLQGTKRLARKALQYVVDNDRDSLTIVHKGNIMKFTEGAFKEWAYEVAAEEFGATLLDGGPWMQFKNPKTGKNVIVKDAIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEVGGIGIAPGANLSDTIAMFEATHGTAPKYAGKDQVNPGSLILSAEMMLRHMGWTEAADLIIKGTNGAISAKTVTYDFHRLMEGAKLLSSSAFGDALISHM
>NZ_CP014870.1|WP_064678743.1|4436948_4439540_-|leucine--tRNA-ligase
MRPQYDPARVESTAQAKWLEDDVFRAVEDEARPKFYACSMLPYPSGKLHMGHVRNYTINDMLARHMRMKGFNVLMPMGWDAFGLPAENAAMQSGVSPAEWTRLNIADMKAQMQPLGLAFDWSREIATCDPQYYKWSQWFFLKLLEKGVAYKKTQTVNWDPVDQTVLANEQVIDGRGWRSGALVEQREIPGYYLRITQYAEELLSAIDTLDGWPDRVRTMQRNWIGKASGVRLAFAHRIRDASGQLIDAGMLWVFTTRVDTLMGVTFCAISPEHALSRRALELDPGLEPQVKACRQAAEAGPATSAQVKIGVPSGLHVEHPLTGEPVALWITNYVLSEYGEGALMAVPAHDERDFDFANQYGLPVRQVIACDDQVYDFQDWSDSHAGRDGHLINSGAYDGLTVAQATQAIVAALVERGMGEEATTWRLRDWGISRQRYWGTPIPIIRCEHCGDVPVPYSDLPVVLPTDCIPDGSANPLLAHAGFRQVACPRCAAPALRETDTLDTFVDSSWYFMRYCDPDSDTAMVGPGSRYWMAIDQYIGGIEHAVLHLLYARFWTRAMRDEGLVAFSEPFKNLFTQGMLLRESYYRAADDGSRQWFYPAQVTVQYDEKGRPVKSTALEDGLPVIIGGVEKMSKSKNNVVEPKDIIDRFGADTARLFTIFAGPPDQDTIWSDSGVEGAYRFLRRLWTFACDSQARDGRDDGVEDVAESRRVRFEMHRLLQQVNSDYERMQYNTVVSGAMKMLKVLEGGRAAGLQVTREGMAILLQVLNPVTPHITQVLWAELGFPGDIYDSSWPVPDNEALKQDEVKMMVQVNGKLRGEILIQADADHDAIRIRALADPVLRSHLEGASRMIVVPNRLVNFVI
>NZ_CP014870.1|WP_003223812.1|4440393_4440807_+|NADH-quinone-oxidoreductase-subunit-A
MPEATGLMAHNWGFAIFLLGVVGLCAFMLGVSSLLGSKAWGRSKNEPFESGMLPTGGARLRLSAKFYLVAMLFVIFDIEALFLFAWSVSVRESGWTGFVEALVFIAILLAGLVYLFRVGALDWAPEARRKRQAKLKQ
>NZ_CP014870.1|WP_050682721.1|4440817_4441492_+|NADH-quinone-oxidoreductase-subunit-B
MQYNLTRIDPDAPNEQYPIGQRETVSDPLEDQVHKNIFMGKLEDVLNGTINWGRKNSLWPYNFGLSCCYVEMTTAFTAPHDIARFGAEVIRASPRQADFMVIAGTCFIKMAPIIQRLYEQMLEPKWVISMGSCANSGGMYDIYSVVQGVDKFLPVDVYVPGCPPRPEAFLQGLMLLQESIGQERRPLSWVVGDQGVYRAEMPSQKEQRREQRIAVTNLRSPDEV
>NZ_CP014870.1|WP_064678744.1|4441564_4443349_+|NADH-quinone-oxidoreductase-subunit-C/D
MTTGSALYIPPYKADDQDVVVELNNRFGPEAFSAQPTRTGMPVLWVARARLVEVLTFLRNLPKPYVMLYDLHGVDERLRTKRQGLPSGADFTVFYHLMSIERNSDVMIKVALSESDLSVPTVTHIWPNANWYEREVWDMYGIDFKGHPHLTRIMMPPTWEGHPLRKDFPARATEFDPFSLTLAKQQLEEEAARFKPEDWGMKRSGANEDYMFLNLGPNHPSAHGAFRIILQLDGEEIVDCVPDVGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLSVEKLAGIKVPEKVDVIRIMMAEFFRITSHLLFLGTYIQDVGAMTPVFFTFTDRQKAYTVIEAITGFRLHPAWYRIGGVAHDLPRGWEKLVKDFVEWMPKRLDEYQKAALDNSILKGRTIGVAAYNTKEAFEWGVTGAGLRSTGCDFDLRKARPYSGYENFEFEVPLAVNGDAYDRCIVRVEEMRQSIKIIEQCMRNMPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGGTMSYRTRIRTPSFPHLQQIPSVIKGSMVADLIAYLGSIDFVMADVDR
>NZ_CP014870.1|WP_008146039.1|4443351_4443849_+|NADH-quinone-oxidoreductase-subunit-NuoE
MNSTLIQTDRFALSETERSAIEHELHHYEDPRAASIEALKIVQKERGWVPDGALYAIGEILGIPASDVEGVATFYSQIFRQPVGRHIIRVCDSMVCYIGGHESVVSEIQSNLGIGLGQTTADGRFTLLPVCCLGNCDKAPALMIDDDTFGDVQPAGVAKLLEGYV
>NZ_CP014870.1|WP_064678745.1|4443845_4445201_+|NADH-quinone-oxidoreductase-subunit-NuoF
MTLTSFGPANRIKRSAESHPLTWRLRDDGEAVWLDEYQAKNGYAAARKAFADMAQDDIVQTVKDAGLKGRGGAGFPTGVKWGLMPKDESINIRYLLCNADEMEPNTWKDRMLMEQLPHLLIEGMLISARALKTYRGYIFLRGEYTTAAKHLNRAVEEAKAAGLLGKNILGSGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPAAVGVWGKPTCVNNVETLCNVPAIIADGVDWYKSLAREGSEDMGTKLMGFSGKVKNPGLWELPFGVTGRELFEDYAGGMRDGYKLKCWQPGGAGTGFLLPEHLDAQMYAGGIAKVGTRMGTGLAMAVDDSVNMVSLLRNMEEFFSRESCGFCTPCRDGLPWSVKLLRAIENGEGQAGDIETLLGLVGFLGPGKTFCAHAPGAVEPLGSAIKYFRHEFEAGIAPTSAVVPPLARPIVVGA
>NZ_CP014870.1|WP_064678746.1|4445338_4448053_+|NADH-quinone-oxidoreductase-subunit-NuoG
MATIHVDGKELEVDGADNLLQACLSLGLDIPYFCWHPALGSIGACRQCAVKQYTDENDKRGRIVMSCMTPATDGSWISIDDEEAKVFRASVVEWLMTNHPHDCPVCEEGGHCHLQDMTVMTGHNERRYRFTKRTHQNQDLGPFIGHEMNRCIACYRCVRFYKDYAGGTDLGVFGAHDNVYFGRVEDGTLESEFSGNLTEVCPTGVFTDKTHSERYNRKWDMQFSPSICHGCSSGCNISPGERYGELRRIENRFNGSVNQYFLCDRGRFGYGYVNRKDRPRQPLLANGAKLTLDEALDKAADLLRGRNIVGIGSPRASLESNYALRELVGAEHFYSGIEASELERIRLVMQVLKDSPLPIPNMRDIEDHDAVFVLGEDLTQTAARMALSLRQSVKGKAEDMADAMRVQPWLDAAVKNIGQDALNPLFIASLAETKLDDIAEECVHAAPDDLARIGFAVAHALDASAPAVEGLDAEALELAKRIADALLAAKRPLIIAGTSLGSKALIEAAANIAKALKLREKNGSISLIVPEANSLGLAMLGGDSVDAALQAVIDGKADAIVVLENDLYTRTDKAKVDAALTAAKVLIVADHQKTATSDRAHLVLPAASFAEGDGTLVSQEGRAQRFFQVFDPTYLDASILVHEGWRWLHALRATLLNQPIDWTQLDHVTAAVAASTPQLNRIVDAAPSAAFRIKGLKLAREPLRYSGRTAMRADISVHEPRTSQDKDTAFSFSMEGYSGSVEPRQQVPFAWSPGWNSPQAWNKFQDEVGGHIRAGDPGTRLIESTGDSLNWFASVPRAFNPAPGTWQVVPFFHLFGSEENSSKAAPVQERIPAAYVALAKSEADRLGVNDGALLSLSVAGQTLRLPLRINEELGAGLVALPAGIAGIPPAIFGKSVDGLQEAAQ
>NZ_CP014870.1|WP_064678747.1|4448049_4449057_+|NADH-quinone-oxidoreductase-subunit-NuoH
MTWFTPEVIDVIISVLKAIVILLAVVVCGALLSWVERRLLALWQDRYGPNRVGPFGAFQIAADMIKMFFKEDWTPPFADKVIFTLAPVVAMSALLIAFAIIPITPTWGVADINIGILFFFAMAGLSVYAVLFAGWSSNNKFALLGSLRASAQTVSYEVFMGLSLMGIVIQVGSFNMRDIVEYQAQNMWFVIPQIFGFLTFFIAGVAVTHRHPFDQPEAEQELADGYHIEYAGMKWGMFFVGEYIGIVLISALLVTLFFGGWHGPFGILPQIPFIWFALKTAFFIMFFILLRASIPRPRYDQVMDFSWKFCLPLTLVNMLVTAAIVLLNTPAVAAQ
>NZ_CP014870.1|WP_052967023.1|4449066_4449615_+|NADH-quinone-oxidoreductase-subunit-NuoI
MMKYIFDIVHGFFTQLRSLVMIFGHAFRKRDTLQYPEEAVYLPPRFRGRIVLTRDPDGEERCVACNLCAVACPVGCISLQKAETDDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFEMAEFKRQDLVYEKEDLLISGPGKNPDYNFYRVAGMAIAGKPKGSAQNEAQPINVKSLLP
>NZ_CP014870.1|WP_007905076.1|4449624_4450128_+|NADH-quinone-oxidoreductase-subunit-J
MEFAFYFASGIAVVSTLRVITNTNPVHALLYLIISLIAVAMTFFALGAPFAGVLEVIAYAGAIMVLFVFVVMMLNLGPASVQQERVWLKPGIWLGPVALGTLLLVELLYVLFSDASGQAIGHTTVDAKAVGISLFGPYLLVVELASMLLLAAAVTAFHLGRNEAKEQ

Crispr_ID: NZ_CP014870_14

• CRISPR_ID: NZ_CP014870_14
• CRISPR_location: 4882833-4882948
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_14

Consensus_repeat	Method
GCGCGTTATCGTTGACGATTTTCGCGAGCA	CRISPRCasFinder

spacers of NZ_CP014870_14

>14.1|4882863|56|NZ_CP014870|CRISPRCasFinder
GGCTCGCTCCCACAGGGGACCGCGGAAACCAACGGCGCTGCGGGGTTTCAGGTATG

CRISPR arrays and Neighbor proteins around NZ_CP014870_14

CRISPR arrays

The CRISPR arrays of NZ_CP014870_14

>merge|NZ_CP014870|14|4882833-4882948|CRISPRCasFinder
GCGCGTTATCGTTGACGATTTTCGCGAGCAGGCTCGCTCCCACAGGGGACCGCGGAAACCAACGGCGCTGCGGGGTTTCAGGTATGGCGCGTTATCGTTGACGATTTTCGCGAGCA

>NZ_CP014870|14|13|4882833-4882948|CRISPRCasFinder
GCGCGTTATCGTTGACGATTTTCGCGAGCA	GGCTCGCTCCCACAGGGGACCGCGGAAACCAACGGCGCTGCGGGGTTTCAGGTATG
GCGCGTTATCGTTGACGATTTTCGCGAGCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064679081.1|4878627_4880199_+|flagellar-hook-length-control-protein-FliK	unknown	unknown	gnl|CDD|376734
NZ_CP014870.1|WP_064680774.1|4884031_4884865_-|CheW-domain-containing-protein	unknown	unknown	gnl|CDD|214588
NZ_CP014870.1|WP_064679088.1|4885907_4886801_-|flagellar-motor-protein-MotD	unknown	unknown	gnl|CDD|181618
NZ_CP014870.1|WP_064679082.1|4880195_4880525_+|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein	unknown	unknown	gnl|CDD|225166
NZ_CP014870.1|WP_064679092.1|4891039_4891828_-|protein-phosphatase-CheZ	unknown	unknown	gnl|CDD|377318
NZ_CP014870.1|WP_064679078.1|4876281_4877037_-|heme-ABC-transporter-permease	unknown	unknown	gnl|CDD|273492
NZ_CP014870.1|WP_064679089.1|4886815_4887556_-|flagellar-motor-protein	unknown	unknown	gnl|CDD|181654
NZ_CP014870.1|WP_064679090.1|4887555_4888701_-|chemotaxis-response-regulator-protein-glutamate-methylesterase	unknown	unknown	gnl|CDD|234828
NZ_CP014870.1|WP_064679075.1|4873664_4875653_-|heme-lyase-CcmF/NrfE-family-subunit	unknown	unknown	gnl|CDD|224061
NZ_CP014870.1|WP_064679084.1|4883067_4883460_-|DUF2802-domain-containing-protein	unknown	unknown	gnl|CDD|378523
NZ_CP014870.1|WP_162493647.1|4891850_4892222_-|chemotaxis-protein-CheY	unknown	unknown	gnl|CDD|381150
NZ_CP014870.1|WP_064679077.1|4876108_4876285_-|heme-exporter-protein-CcmD	unknown	unknown	gnl|CDD|225656
NZ_CP014870.1|WP_064675632.1|4881509_4882688_-|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl|CDD|366234
NZ_CP014870.1|WP_064679080.1|4877793_4878429_-|cytochrome-c-biogenesis-heme-transporting-ATPase-CcmA	unknown	unknown	gnl|CDD|184125
NZ_CP014870.1|WP_064679085.1|4883460_4883946_-|chemotaxis-protein-CheW	unknown	unknown	gnl|CDD|238374
NZ_CP014870.1|WP_064679087.1|4885075_4885864_-|ParA-family-protein	unknown	unknown	gnl|CDD|224113
NZ_CP014870.1|WP_064679076.1|4875656_4876112_-|cytochrome-c-maturation-protein-CcmE	unknown	unknown	gnl|CDD|237317
NZ_CP014870.1|WP_064679091.1|4888751_4891016_-|chemotaxis-protein-CheA	unknown	unknown	gnl|CDD|223716
NZ_CP014870.1|WP_064679079.1|4877128_4877797_-|heme-exporter-protein-CcmB	unknown	unknown	gnl|CDD|200083
NZ_CP014870.1|WP_064679083.1|4880689_4880932_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064679081.1|4878627_4880199_+|flagellar-hook-length-control-protein-FliK	gnl|CDD|376734	pfam02120, Flg_hook, Flagellar hook-length control protein FliK. This is the C terminal domain of FliK. FliK controls the length of the flagellar hook by directly measuring the hook length as a molecular ruler. This family also includes YscP of the Yersinia type III secretion system, and equivalent proteins in other pathogenic bacterial type III secretion systems.	8.42218e-14
NZ_CP014870.1|WP_064680774.1|4884031_4884865_-|CheW-domain-containing-protein	gnl|CDD|214588	smart00260, CheW, Two component signalling adaptor domain.	2.54789e-15
NZ_CP014870.1|WP_064679088.1|4885907_4886801_-|flagellar-motor-protein-MotD	gnl|CDD|181618	PRK09038, PRK09038, flagellar motor protein MotD; Reviewed.	1.50155e-169
NZ_CP014870.1|WP_064679082.1|4880195_4880525_+|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein	gnl|CDD|225166	COG2257, COG2257, Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown].	3.57618e-31
NZ_CP014870.1|WP_064679078.1|4876281_4877037_-|heme-ABC-transporter-permease	gnl|CDD|273492	TIGR01191, Heme_exporter_protein_C, heme exporter protein CcmC. This model describes the cyt c biogenesis protein encoded by ccmC in bacteria. It must be noted an arabidopsis, a tritcum and a piscum plant proteins were recognizable in the clade. Quite likely they are of organellar origin. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes, ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in the heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other].	4.99644e-92
NZ_CP014870.1|WP_064679089.1|4886815_4887556_-|flagellar-motor-protein	gnl|CDD|181654	PRK09109, motC, flagellar motor protein; Reviewed.	4.10926e-159
NZ_CP014870.1|WP_064679090.1|4887555_4888701_-|chemotaxis-response-regulator-protein-glutamate-methylesterase	gnl|CDD|234828	PRK00742, PRK00742, chemotaxis-specific protein-glutamate methyltransferase CheB.	0
NZ_CP014870.1|WP_064679075.1|4873664_4875653_-|heme-lyase-CcmF/NrfE-family-subunit	gnl|CDD|224061	COG1138, CcmF, Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP014870.1|WP_064679084.1|4883067_4883460_-|DUF2802-domain-containing-protein	gnl|CDD|378523	pfam10975, DUF2802, Protein of unknown function (DUF2802). This bacterial family of proteins has no known function.	2.47998e-17
NZ_CP014870.1|WP_162493647.1|4891850_4892222_-|chemotaxis-protein-CheY	gnl|CDD|381150	cd19923, REC_CheY_CheY3, phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins. CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	8.55867e-72
NZ_CP014870.1|WP_064679077.1|4876108_4876285_-|heme-exporter-protein-CcmD	gnl|CDD|225656	COG3114, CcmD, Heme exporter protein D [Intracellular trafficking and secretion].	1.02314e-20
NZ_CP014870.1|WP_064675632.1|4881509_4882688_-|DDE-type-integrase/transposase/recombinase	gnl|CDD|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	4.88767e-17
NZ_CP014870.1|WP_064679080.1|4877793_4878429_-|cytochrome-c-biogenesis-heme-transporting-ATPase-CcmA	gnl|CDD|184125	PRK13538, PRK13538, cytochrome c biogenesis heme-transporting ATPase CcmA.	9.19269e-129
NZ_CP014870.1|WP_064679085.1|4883460_4883946_-|chemotaxis-protein-CheW	gnl|CDD|238374	cd00732, CheW, CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.	5.62294e-57
NZ_CP014870.1|WP_064679087.1|4885075_4885864_-|ParA-family-protein	gnl|CDD|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	2.51338e-66
NZ_CP014870.1|WP_064679076.1|4875656_4876112_-|cytochrome-c-maturation-protein-CcmE	gnl|CDD|237317	PRK13254, PRK13254, cytochrome c maturation protein CcmE.	6.55323e-83
NZ_CP014870.1|WP_064679091.1|4888751_4891016_-|chemotaxis-protein-CheA	gnl|CDD|223716	COG0643, CheA, Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms].	0
NZ_CP014870.1|WP_064679079.1|4877128_4877797_-|heme-exporter-protein-CcmB	gnl|CDD|200083	TIGR01190, Heme_exporter_protein_B, heme exporter protein CcmB. This model describes the cyt c biogenesis protein encoded by ccmB in bacteria. Bacterial c-type cytochromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes: ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome C. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other].	2.53102e-70
NZ_CP014870.1|WP_064679092.1|4891039_4891828_-|protein-phosphatase-CheZ	gnl|CDD|377318	pfam04344, CheZ, Chemotaxis phosphatase, CheZ. This family represents the bacterial chemotaxis phosphatase, CheZ. This protein forms a dimer characterized by a long four-helix bundle, composed of two helices from each monomer. CheZ dephosphorylates CheY in a reaction that is essential to maintain a continuous chemotactic response to environmental changes. It is thought that CheZ's conserved residue Gln 147 orientates a water molecule for nucleophilic attack at the CheY active site.	8.09735e-93

Protein sequences

>NZ_CP014870.1|WP_064675632.1|4881509_4882688_-|DDE-type-integrase/transposase/recombinase
MPWNRESPMDQRIKLIGDWLQGSYSKSELARHYGLSRPTLDKWLARYETQGIDGLKELSRRPHTSPFKISDEVLELLVAYKREHHSWGPEKLVHNLKIDHPELSWPTVSTAGEWLKRAGLVQKRRFLNRPPAGKNPLRDATAPNQTWAADFKGDFALQNGQRCYPLTITDHVSRFLLLCRAQSSVAGAREGFDWAFREYGLPNVIRTDNGSPFASTGISRISSLAAWWIRLGIYPERIQPGRPDQNGRHERMHRTLKAALLHAPERNLVEQQLAFEQFRQEFNYVRPHKALEMKVPADLYKPSPRQYDGRVPEADYASDMRIRMIRQNGSMKWKGKMIFVSESLAGEALGLKEVDDDVWDIYLCNYLLGRLKSGESRLSSQQKRKGCPRFQS
>NZ_CP014870.1|WP_064679083.1|4880689_4880932_-|hypothetical-protein
MEINAIRTAGEIITFDPGAPGHSELATCTVRDDNHANDIFLVRIIDHFWLMEHLPLVGKRIRFSRTGSSGHLIAEDIELE
>NZ_CP014870.1|WP_064679082.1|4880195_4880525_+|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein
MKTPDTPRQAIALKYDGNHAPTLTAKGDDALAEAILKIARDCEVPIYENAELVKLLARMELGESIPEELYRTIAEIIAFAWNLKGKFPEEHDQNAPGGEKDITDRGEDY
>NZ_CP014870.1|WP_064679081.1|4878627_4880199_+|flagellar-hook-length-control-protein-FliK
MTGEMNILPLPPTVSATPRAQAVGGELIKLLTPTEGLIGTGQGAKAEVLSLKQAEQTFQLLLKVTLDSGRQTTVQATSTQPLLQGTHLAITQPSAGNLAISVQQAVASSVATLTRIDTAQLPAGTLLQGKVLTSQVMPQVPGQPMVFRSMVSLLNTALSGSTLSIDGPRPLPVGTLLSARVQDAHTLKFVPLSSRQEQLAVTQQLVSQQSRQGSINGLLKLLQNLPADQTSSEVRAAVDKLLADLPDIHQLSTPKGLAQALAGSGLFLEAKLLGGQNPTLAPDMKGDLLTLIAQLTPGLPANTNLNAIIAANTLAQALPGFVRSALGMLGQVSAKPSPTSFPLPERLLQSADGEDDLEHLLRLAAAAVSRLQSHQLSSLEQTGVTSDGRQMSTWQLEIPMRNLQDIVPLQVKFQREEAPEQQQPKERHEERPPKQQLWRVELAFDMEPLGPLQVQAQLISGSLSSQLWAERPYTASLIESNLAALRQRLLDSGLNVGDIDCHLGTPPQGAQTRLEQRWVDETA
>NZ_CP014870.1|WP_064679080.1|4877793_4878429_-|cytochrome-c-biogenesis-heme-transporting-ATPase-CcmA
MTSPVLQTVALACERDLRLLFENLELRLASGEMVQISGPNGSGKTSLLRLLCGLMQPTAGQVLLNGQPLNEQRSELAHNLLWIGHAAGIKDLLTPEENLSWLCALHQPASREAIWQALAAVGLRGFEDVPCHTLSAGQQRRVALARLYLDSPALWILDEPFTALDKQGVAQLEEHLAAHCESGGMVVLTTHHTLSRMPAGYRDIDLGNWAV
>NZ_CP014870.1|WP_064679079.1|4877128_4877797_-|heme-exporter-protein-CcmB
MTVFGLLVAREARLLFRRPAELANPLVFFAIVVSLFPLAVGPESQLLQTLSPGLVWVAALLSVLLSLDGLFRSDFEDGSLEQWVLSSHPLPLLVLAKVLAHWAFSGLALVLLAPLLALMLGLPAACLPVLLLSLLLGTPVLSLLGAVGAALTVGLKRGGLLLALLILPLYIPVLILGSGALQAALQGMPATGYLLWLGSLTALAITLTPFAIAAGLKISVGE
>NZ_CP014870.1|WP_064679078.1|4876281_4877037_-|heme-ABC-transporter-permease
MNWTWFHKLGSPKWFYGISGKLLPWLSVAALLLIGVGVVWGLAFAPPDYQQGNSFRIIYIHVPAAMLAQSIYVMLAVCGIVGLVWKMKLADVALQCAAPIGAWMTAVALVTGAIWGKPTWGSWWVWDARLTSMLILLFLYFGLIALGNAISNRDSAAKACAVLAIVGVINIPIIKYSVEWWNTLHQGATFTLTEKPAMPVEMWLPLLLTVLGFYCFFGAVLLLRMRLEVLKREARASWVKAEVQNSLEVAR
>NZ_CP014870.1|WP_064679077.1|4876108_4876285_-|heme-exporter-protein-CcmD
MSFASFGDFLAMGHHGLYVWSAYGICLAVLVLNVAAPVLARKRYLQQEARRLRRENGK
>NZ_CP014870.1|WP_064679076.1|4875656_4876112_-|cytochrome-c-maturation-protein-CcmE
MNPLRKKRLIIILAILVGVGAAVGLALSALQQNINLFYTPTQIANGEAPQDTRIRAGGMVEKGSLQRSGDSLDVKFVVTDFKESVTISYRGILPDLFREGQGIVALGKLNADGVVVADEVLAKHDEKYMPPEVTKALKDSGQSAPTPAKEG
>NZ_CP014870.1|WP_064679075.1|4873664_4875653_-|heme-lyase-CcmF/NrfE-family-subunit
MTSGIFIPELGHLAMILALCFALVQAVVPLLGAWRGDRLWMSLAQPAAWGQFAFLLFAFGCLTYAFMADDFSVAYVAGNSNSALPWYYKFSAVWGAHEGSLLLWALILGGWTFAVSVFSRQLPQVMLARVLSIMGMISIGFLLFLILTSNPFERILPQIPTDGRDLNPLLQDIGLIVHPPMLYMGYVGFSVAFAFAIAALLGGRLDAAWARWSRPWTIVAWAFLGIGITLGSWWAYYELGWGGWWFWDPVENASFMPWLVGTALIHSLAVTEKRGVFKSWTVLLAIAAFSLSLLGTFLVRSGVLTSVHAFASDPERGVFILIFLLFVVGGSLTLFALRAPVVKSHVGFNLWSRETLLLGNNLVLVVAASMILLGTLYPLILDAMTGAKLSVGPPYFNALFIPLMALLMVVMAVGMLVRWKDTPVKWLLGMLTPVLLGSAALAVVAGIAYGDFNWAVIATFMLAAWVLLAGVRDIFDKTRHKGLIKGLPTLTRSYWGMQVAHLGIAVCALGVVLSSQNSAERDLRLAPGESMDLGGYQFVFEGAKHYEGPNFTSDKGTVRVIKGGKEISVLHPEKRLYTVQNSVMTEAGIDAGFTRDLYVALGEPLGEGAWAVRVHVKPFVRWIWFGGLLTGLGGLLAALDPRYRVKVKSRVREALGMSEATA
>NZ_CP014870.1|WP_064679084.1|4883067_4883460_-|DUF2802-domain-containing-protein
MILEAAVIVLFLLWAGTLAMFLAYVRAQKLIAAQQAGGDALRDQRIKDLARRVDDYQNSNVRMGQELQELRAVVGPLPDKLIQLEQRDPSSLSFAQAARLVGMGASVNELTQSCGLTQAEAELMSKLHKS
>NZ_CP014870.1|WP_064679085.1|4883460_4883946_-|chemotaxis-protein-CheW
MNDKAAAAKGSEDPILQWVTFKLDNETYGINVMRVQEVLRYTEIAPVPGAPSYVLGIINLRGNVVTVIDTRQRFGLMNAEISDNTRIVIIEADKQVVGIMVDSVAEVVYLRQSEIETAPNVGNDESAKFIQGVCNKNNELLILVELDKMMSEEEWSDLENI
>NZ_CP014870.1|WP_064680774.1|4884031_4884865_-|CheW-domain-containing-protein
MNRPVKITSRPQLALQSYLDSLLMDATDELTADVETLPEVVEDDSALDEFQAAVLEEQARDAQVVPVPLASIPVTVIEAPAPDATLSAPLQTLVPPLVEVHQASGATPPTIETNGRPSWAAEPFECLLFDVAGLTLAVPLVCLGSIYSLTGHELTPLFGQPEWFLGILPSQAGNLKVLDTARWVMPDRYRDDFRQGLQYVISVQGYEWALAVHQVSRSLRLDPNEIKWRSHRGQRPWLAGTVIEHMCALLDVAELAELIASGGAKHMDGNKPARQPT
>NZ_CP014870.1|WP_064679087.1|4885075_4885864_-|ParA-family-protein
MRVWAVANQKGGVGKTTSSIALAGLLAEAGKRVVVVDLDPHGSMTSYFGYDPDRLEHSVYDLFLHKGSVPAGLPGQLLLSTSHEHISLLPSSTALATLERQSPGQSGLGLVIAKSLAQLWQDFDYAVIDSPPLLGVLMVNALAASQQLVIPVQTEHLAVKGLERMVSTLTMINRSRKQALPFSIVPTLYDRRTQASIGTLRLLRDMYPEEIWQGHIPVDTRLRDASRAGMTPSQFDSKSRGVLAYRALLKHLLAAQLVPQVA
>NZ_CP014870.1|WP_064679088.1|4885907_4886801_-|flagellar-motor-protein-MotD
MARRRQPEEPVNRERWLVSYADFITLLFAFFVVMYSISSVNEGKYKVISEALIGVFNDADRALQPIPVGDERPKTVTPAKPLVKDSEQIDAGIAQAASDPLKSIADDISAAFGDLISSSQMTVRGNELWVEIELNSSLLFGSGDAMPSDIAFNIIDKVAAILKPFDNPVHVEGFTDDRPIRTAQYPTNWELSSARSASIVRMLAMQGVNPGRLASVGYGEFQPVANNATAEGRARNRRVVLVVSRNLDIRRSLTGTGSANAKPDAALKRAGTQTAPTPIKSPGRESAVNSPSPALIR
>NZ_CP014870.1|WP_064679089.1|4886815_4887556_-|flagellar-motor-protein
MDVLSLIGIIMAFVAIIGGNYLEGGHLGALANGPAALIVIGGTVGAALLQSPMSAFKRALQILVWILFPPRVDLAGGIDRVVGWSLTARKEGLLGLEGVADAEPDSYSRKGLQLLVDGAEPEAIRSILEVDFYTQESRDVEAAKVFESMGGYAPTIGIIGAVMGLIHVMGNLADPSQLGSGIAVAFVATIYGVASANLILLPIAAKLKSVALRQSRYREMLLEGILSIAEGENPRSIELKLHGFMD
>NZ_CP014870.1|WP_064679090.1|4887555_4888701_-|chemotaxis-response-regulator-protein-glutamate-methylesterase
MAVKVLVVDDSGFFRRRVSEILSADPNIQVVGTATNGKEAIDQALALKPDVITMDYEMPMMDGITAVRHIMQRCPTPVLMFSSLTHEGARVTLDALDAGAVDFLPKNFEDISRNPEKVKQLLCEKILSISRSNRRASTYSTYSAPAPVAAPAPAPTPAPSSVSSYGSSAPARPAPAPIPARTPAPASSSPAPRRKAYKLVAIGTSTGGPVALQRVLTQLPANFPAPIVLIQHMPAAFTKAFAERLDKLCRIHVKEAEDGDILRPGLALLAPGGKQMMVDGRGAVKILPGDERLNYRPCVDITFGSAAKSYGDKVLAVVLTGMGADGREGARLLKQSGSSIWAQDEASCVIYGMPMAIVKAELADAVYGLDEIGKHLVEACI
>NZ_CP014870.1|WP_064679091.1|4888751_4891016_-|chemotaxis-protein-CheA
MSFGADEEILQDFLVEAGEILEQLSEQLVELESRPDDADLLNAIFRGFHTVKGGAGFLQLHELVECCHIAENVFDILRKGERRVDSELMDVVLEALDAVNGMFTEVRERSPVTAATPELLAALARLAEPQSTDQAAPAAAVAPVADSPSDDITDNEFEQLLDSLNAVKAQAEAAPCAPAPVSGNAAASDEITDAEFESLLDQLHGKGRFAVDAVVAPAAPAAPATPATPKAAGDSSDITDEEFEALLDQLHGKGNFAVEALESAIASAPVPAAPTAAAVGSDLISDHEFEALLDELHGKGKFSEIGTATGASAPVATPLAKAAAPQSVAKAAEPKAPEPKAEAAKAAPAPVRAPAAPPPEKPASEAETTVRVDTARLDEIMNMVGELVLVRNRLVRLGANSADEAMSKAVSNLDVVTADLQTAVMKTRMQPIKKVFGRFPRLVRDLARQLKKEINLELVGEETDLDKNLVEALADPLVHLVRNAVDHGIESPEEREAAGKSRGGKVILAAEQEGDHILLSISDDGKGMDPNVLRAIAVKRGVMDKDAAERLSDTECYNLIFAPGFSTKTEISDVSGRGVGMDVVKTKISQLNGSINIYSAKGQGSKIVIKVPLTLAIMPTLMVMLANQAFAFPLVNVNEIFHLDLSRTNVVDGQEVVIVRDKALPLFYLKRWLVRSAAHEEQREGHVVILTVGTQRIGFVVDQLVGQEEVVIKPLGKMLQGTPGMSGATITGDGRIALILDVPSMLKRYATRRI
>NZ_CP014870.1|WP_064679092.1|4891039_4891828_-|protein-phosphatase-CheZ
MEHKESSQGDFESTLKKHAVELVESLEKGKFGDAVQLIHELNQTRDRGLYREVGKLTRELHSAIVNFQIDPHMPQAEEVSQITDATERLGYVVRLTEAAANRTMDLVENATPLVNSLSNEAQALSTDWGRFMRREVGAEEFRELARRVDGFLTRSSADNRIVSSNLNDILLAQDYQDLTGQVIKRVTQLVTEVESNLLKLVLMASQVDRFAGIEHDREAMRAEKDPQKQLSQGEGPQIHADKREDVVSGQDDVDDLLSSLGF
>NZ_CP014870.1|WP_162493647.1|4891850_4892222_-|chemotaxis-protein-CheY
MKILIVDDFSTMRRIIKNLLRDLGFTNTVEADDGTTAIPMLNSGSIDFLVTDWNMPGMTGIDLLRHVRADEKLKHLPVLMVTAEAKREQIIEAAQAGVNGYVVKPFTAQALKEKIEKIFERIG

Crispr_ID: NZ_CP014870_15

• CRISPR_ID: NZ_CP014870_15
• CRISPR_location: 4884954-4885059
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_15

Consensus_repeat	Method
CCATCGCGAGCAAGCTTGCTCCTAC	CRISPRCasFinder

spacers of NZ_CP014870_15

>15.1|4884979|56|NZ_CP014870|CRISPRCasFinder
AGCGAAGAACCTGAGAGCACCGCGGGGTGTCAGGTTTTTAGCGTTATCGTTGACGG

CRISPR arrays and Neighbor proteins around NZ_CP014870_15

CRISPR arrays

The CRISPR arrays of NZ_CP014870_15

>merge|NZ_CP014870|15|4884954-4885059|CRISPRCasFinder
CCATCGCGAGCAAGCTTGCTCCTACAGCGAAGAACCTGAGAGCACCGCGGGGTGTCAGGTTTTTAGCGTTATCGTTGACGGCCATCGCGAGCAAGCTTGCTCCTAC

>NZ_CP014870|15|14|4884954-4885059|CRISPRCasFinder
CCATCGCGAGCAAGCTTGCTCCTAC	AGCGAAGAACCTGAGAGCACCGCGGGGTGTCAGGTTTTTAGCGTTATCGTTGACGG
CCATCGCGAGCAAGCTTGCTCCTAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064679081.1|4878627_4880199_+|flagellar-hook-length-control-protein-FliK	unknown	unknown	gnl|CDD|376734
NZ_CP014870.1|WP_064680774.1|4884031_4884865_-|CheW-domain-containing-protein	unknown	unknown	gnl|CDD|214588
NZ_CP014870.1|WP_064679088.1|4885907_4886801_-|flagellar-motor-protein-MotD	unknown	unknown	gnl|CDD|181618
NZ_CP014870.1|WP_064679082.1|4880195_4880525_+|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein	unknown	unknown	gnl|CDD|225166
NZ_CP014870.1|WP_064679092.1|4891039_4891828_-|protein-phosphatase-CheZ	unknown	unknown	gnl|CDD|377318
NZ_CP014870.1|WP_064679078.1|4876281_4877037_-|heme-ABC-transporter-permease	unknown	unknown	gnl|CDD|273492
NZ_CP014870.1|WP_064679090.1|4887555_4888701_-|chemotaxis-response-regulator-protein-glutamate-methylesterase	unknown	unknown	gnl|CDD|234828
NZ_CP014870.1|WP_007975361.1|4893126_4893957_-|flagellar-synthesis-regulator-FleN	unknown	unknown	gnl|CDD|349758
NZ_CP014870.1|WP_064679084.1|4883067_4883460_-|DUF2802-domain-containing-protein	unknown	unknown	gnl|CDD|378523
NZ_CP014870.1|WP_162493647.1|4891850_4892222_-|chemotaxis-protein-CheY	unknown	unknown	gnl|CDD|381150
NZ_CP014870.1|WP_064679095.1|4894073_4895405_-|flagellar-biosynthesis-protein-FlhF	unknown	unknown	gnl|CDD|235570
NZ_CP014870.1|WP_064675632.1|4881509_4882688_-|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl|CDD|366234
NZ_CP014870.1|WP_064679080.1|4877793_4878429_-|cytochrome-c-biogenesis-heme-transporting-ATPase-CcmA	unknown	unknown	gnl|CDD|184125
NZ_CP014870.1|WP_064679094.1|4892389_4893130_-|RNA-polymerase-sigma-factor-FliA	unknown	unknown	gnl|CDD|235901
NZ_CP014870.1|WP_064679085.1|4883460_4883946_-|chemotaxis-protein-CheW	unknown	unknown	gnl|CDD|238374
NZ_CP014870.1|WP_064679087.1|4885075_4885864_-|ParA-family-protein	unknown	unknown	gnl|CDD|224113
NZ_CP014870.1|WP_064679089.1|4886815_4887556_-|flagellar-motor-protein	unknown	unknown	gnl|CDD|181654
NZ_CP014870.1|WP_064679091.1|4888751_4891016_-|chemotaxis-protein-CheA	unknown	unknown	gnl|CDD|223716
NZ_CP014870.1|WP_064679079.1|4877128_4877797_-|heme-exporter-protein-CcmB	unknown	unknown	gnl|CDD|200083
NZ_CP014870.1|WP_064679083.1|4880689_4880932_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064679081.1|4878627_4880199_+|flagellar-hook-length-control-protein-FliK	gnl|CDD|376734	pfam02120, Flg_hook, Flagellar hook-length control protein FliK. This is the C terminal domain of FliK. FliK controls the length of the flagellar hook by directly measuring the hook length as a molecular ruler. This family also includes YscP of the Yersinia type III secretion system, and equivalent proteins in other pathogenic bacterial type III secretion systems.	8.42218e-14
NZ_CP014870.1|WP_064680774.1|4884031_4884865_-|CheW-domain-containing-protein	gnl|CDD|214588	smart00260, CheW, Two component signalling adaptor domain.	2.54789e-15
NZ_CP014870.1|WP_064679087.1|4885075_4885864_-|ParA-family-protein	gnl|CDD|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	2.51338e-66
NZ_CP014870.1|WP_064679082.1|4880195_4880525_+|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein	gnl|CDD|225166	COG2257, COG2257, Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown].	3.57618e-31
NZ_CP014870.1|WP_064679078.1|4876281_4877037_-|heme-ABC-transporter-permease	gnl|CDD|273492	TIGR01191, Heme_exporter_protein_C, heme exporter protein CcmC. This model describes the cyt c biogenesis protein encoded by ccmC in bacteria. It must be noted an arabidopsis, a tritcum and a piscum plant proteins were recognizable in the clade. Quite likely they are of organellar origin. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes, ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in the heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other].	4.99644e-92
NZ_CP014870.1|WP_064679090.1|4887555_4888701_-|chemotaxis-response-regulator-protein-glutamate-methylesterase	gnl|CDD|234828	PRK00742, PRK00742, chemotaxis-specific protein-glutamate methyltransferase CheB.	0
NZ_CP014870.1|WP_007975361.1|4893126_4893957_-|flagellar-synthesis-regulator-FleN	gnl|CDD|349758	cd02038, FlhG-like, MinD-like ATPase FlhG. FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) is a major determinant for a variety of flagellation patterns. It effects location and number of bacterial flagella during C-ring assembly.	7.0344e-119
NZ_CP014870.1|WP_064679084.1|4883067_4883460_-|DUF2802-domain-containing-protein	gnl|CDD|378523	pfam10975, DUF2802, Protein of unknown function (DUF2802). This bacterial family of proteins has no known function.	2.47998e-17
NZ_CP014870.1|WP_162493647.1|4891850_4892222_-|chemotaxis-protein-CheY	gnl|CDD|381150	cd19923, REC_CheY_CheY3, phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins. CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	8.55867e-72
NZ_CP014870.1|WP_064679095.1|4894073_4895405_-|flagellar-biosynthesis-protein-FlhF	gnl|CDD|235570	PRK05703, flhF, flagellar biosynthesis protein FlhF.	0
NZ_CP014870.1|WP_064675632.1|4881509_4882688_-|DDE-type-integrase/transposase/recombinase	gnl|CDD|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	4.88767e-17
NZ_CP014870.1|WP_064679080.1|4877793_4878429_-|cytochrome-c-biogenesis-heme-transporting-ATPase-CcmA	gnl|CDD|184125	PRK13538, PRK13538, cytochrome c biogenesis heme-transporting ATPase CcmA.	9.19269e-129
NZ_CP014870.1|WP_064679094.1|4892389_4893130_-|RNA-polymerase-sigma-factor-FliA	gnl|CDD|235901	PRK06986, fliA, flagellar biosynthesis sigma factor; Validated.	3.16854e-129
NZ_CP014870.1|WP_064679085.1|4883460_4883946_-|chemotaxis-protein-CheW	gnl|CDD|238374	cd00732, CheW, CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.	5.62294e-57
NZ_CP014870.1|WP_064679088.1|4885907_4886801_-|flagellar-motor-protein-MotD	gnl|CDD|181618	PRK09038, PRK09038, flagellar motor protein MotD; Reviewed.	1.50155e-169
NZ_CP014870.1|WP_064679089.1|4886815_4887556_-|flagellar-motor-protein	gnl|CDD|181654	PRK09109, motC, flagellar motor protein; Reviewed.	4.10926e-159
NZ_CP014870.1|WP_064679091.1|4888751_4891016_-|chemotaxis-protein-CheA	gnl|CDD|223716	COG0643, CheA, Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms].	0
NZ_CP014870.1|WP_064679079.1|4877128_4877797_-|heme-exporter-protein-CcmB	gnl|CDD|200083	TIGR01190, Heme_exporter_protein_B, heme exporter protein CcmB. This model describes the cyt c biogenesis protein encoded by ccmB in bacteria. Bacterial c-type cytochromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes: ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome C. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other].	2.53102e-70
NZ_CP014870.1|WP_064679092.1|4891039_4891828_-|protein-phosphatase-CheZ	gnl|CDD|377318	pfam04344, CheZ, Chemotaxis phosphatase, CheZ. This family represents the bacterial chemotaxis phosphatase, CheZ. This protein forms a dimer characterized by a long four-helix bundle, composed of two helices from each monomer. CheZ dephosphorylates CheY in a reaction that is essential to maintain a continuous chemotactic response to environmental changes. It is thought that CheZ's conserved residue Gln 147 orientates a water molecule for nucleophilic attack at the CheY active site.	8.09735e-93

Protein sequences

>NZ_CP014870.1|WP_064680774.1|4884031_4884865_-|CheW-domain-containing-protein
MNRPVKITSRPQLALQSYLDSLLMDATDELTADVETLPEVVEDDSALDEFQAAVLEEQARDAQVVPVPLASIPVTVIEAPAPDATLSAPLQTLVPPLVEVHQASGATPPTIETNGRPSWAAEPFECLLFDVAGLTLAVPLVCLGSIYSLTGHELTPLFGQPEWFLGILPSQAGNLKVLDTARWVMPDRYRDDFRQGLQYVISVQGYEWALAVHQVSRSLRLDPNEIKWRSHRGQRPWLAGTVIEHMCALLDVAELAELIASGGAKHMDGNKPARQPT
>NZ_CP014870.1|WP_064679085.1|4883460_4883946_-|chemotaxis-protein-CheW
MNDKAAAAKGSEDPILQWVTFKLDNETYGINVMRVQEVLRYTEIAPVPGAPSYVLGIINLRGNVVTVIDTRQRFGLMNAEISDNTRIVIIEADKQVVGIMVDSVAEVVYLRQSEIETAPNVGNDESAKFIQGVCNKNNELLILVELDKMMSEEEWSDLENI
>NZ_CP014870.1|WP_064679084.1|4883067_4883460_-|DUF2802-domain-containing-protein
MILEAAVIVLFLLWAGTLAMFLAYVRAQKLIAAQQAGGDALRDQRIKDLARRVDDYQNSNVRMGQELQELRAVVGPLPDKLIQLEQRDPSSLSFAQAARLVGMGASVNELTQSCGLTQAEAELMSKLHKS
>NZ_CP014870.1|WP_064675632.1|4881509_4882688_-|DDE-type-integrase/transposase/recombinase
MPWNRESPMDQRIKLIGDWLQGSYSKSELARHYGLSRPTLDKWLARYETQGIDGLKELSRRPHTSPFKISDEVLELLVAYKREHHSWGPEKLVHNLKIDHPELSWPTVSTAGEWLKRAGLVQKRRFLNRPPAGKNPLRDATAPNQTWAADFKGDFALQNGQRCYPLTITDHVSRFLLLCRAQSSVAGAREGFDWAFREYGLPNVIRTDNGSPFASTGISRISSLAAWWIRLGIYPERIQPGRPDQNGRHERMHRTLKAALLHAPERNLVEQQLAFEQFRQEFNYVRPHKALEMKVPADLYKPSPRQYDGRVPEADYASDMRIRMIRQNGSMKWKGKMIFVSESLAGEALGLKEVDDDVWDIYLCNYLLGRLKSGESRLSSQQKRKGCPRFQS
>NZ_CP014870.1|WP_064679083.1|4880689_4880932_-|hypothetical-protein
MEINAIRTAGEIITFDPGAPGHSELATCTVRDDNHANDIFLVRIIDHFWLMEHLPLVGKRIRFSRTGSSGHLIAEDIELE
>NZ_CP014870.1|WP_064679082.1|4880195_4880525_+|EscU/YscU/HrcU-family-type-III-secretion-system-export-apparatus-switch-protein
MKTPDTPRQAIALKYDGNHAPTLTAKGDDALAEAILKIARDCEVPIYENAELVKLLARMELGESIPEELYRTIAEIIAFAWNLKGKFPEEHDQNAPGGEKDITDRGEDY
>NZ_CP014870.1|WP_064679081.1|4878627_4880199_+|flagellar-hook-length-control-protein-FliK
MTGEMNILPLPPTVSATPRAQAVGGELIKLLTPTEGLIGTGQGAKAEVLSLKQAEQTFQLLLKVTLDSGRQTTVQATSTQPLLQGTHLAITQPSAGNLAISVQQAVASSVATLTRIDTAQLPAGTLLQGKVLTSQVMPQVPGQPMVFRSMVSLLNTALSGSTLSIDGPRPLPVGTLLSARVQDAHTLKFVPLSSRQEQLAVTQQLVSQQSRQGSINGLLKLLQNLPADQTSSEVRAAVDKLLADLPDIHQLSTPKGLAQALAGSGLFLEAKLLGGQNPTLAPDMKGDLLTLIAQLTPGLPANTNLNAIIAANTLAQALPGFVRSALGMLGQVSAKPSPTSFPLPERLLQSADGEDDLEHLLRLAAAAVSRLQSHQLSSLEQTGVTSDGRQMSTWQLEIPMRNLQDIVPLQVKFQREEAPEQQQPKERHEERPPKQQLWRVELAFDMEPLGPLQVQAQLISGSLSSQLWAERPYTASLIESNLAALRQRLLDSGLNVGDIDCHLGTPPQGAQTRLEQRWVDETA
>NZ_CP014870.1|WP_064679080.1|4877793_4878429_-|cytochrome-c-biogenesis-heme-transporting-ATPase-CcmA
MTSPVLQTVALACERDLRLLFENLELRLASGEMVQISGPNGSGKTSLLRLLCGLMQPTAGQVLLNGQPLNEQRSELAHNLLWIGHAAGIKDLLTPEENLSWLCALHQPASREAIWQALAAVGLRGFEDVPCHTLSAGQQRRVALARLYLDSPALWILDEPFTALDKQGVAQLEEHLAAHCESGGMVVLTTHHTLSRMPAGYRDIDLGNWAV
>NZ_CP014870.1|WP_064679079.1|4877128_4877797_-|heme-exporter-protein-CcmB
MTVFGLLVAREARLLFRRPAELANPLVFFAIVVSLFPLAVGPESQLLQTLSPGLVWVAALLSVLLSLDGLFRSDFEDGSLEQWVLSSHPLPLLVLAKVLAHWAFSGLALVLLAPLLALMLGLPAACLPVLLLSLLLGTPVLSLLGAVGAALTVGLKRGGLLLALLILPLYIPVLILGSGALQAALQGMPATGYLLWLGSLTALAITLTPFAIAAGLKISVGE
>NZ_CP014870.1|WP_064679078.1|4876281_4877037_-|heme-ABC-transporter-permease
MNWTWFHKLGSPKWFYGISGKLLPWLSVAALLLIGVGVVWGLAFAPPDYQQGNSFRIIYIHVPAAMLAQSIYVMLAVCGIVGLVWKMKLADVALQCAAPIGAWMTAVALVTGAIWGKPTWGSWWVWDARLTSMLILLFLYFGLIALGNAISNRDSAAKACAVLAIVGVINIPIIKYSVEWWNTLHQGATFTLTEKPAMPVEMWLPLLLTVLGFYCFFGAVLLLRMRLEVLKREARASWVKAEVQNSLEVAR
>NZ_CP014870.1|WP_064679087.1|4885075_4885864_-|ParA-family-protein
MRVWAVANQKGGVGKTTSSIALAGLLAEAGKRVVVVDLDPHGSMTSYFGYDPDRLEHSVYDLFLHKGSVPAGLPGQLLLSTSHEHISLLPSSTALATLERQSPGQSGLGLVIAKSLAQLWQDFDYAVIDSPPLLGVLMVNALAASQQLVIPVQTEHLAVKGLERMVSTLTMINRSRKQALPFSIVPTLYDRRTQASIGTLRLLRDMYPEEIWQGHIPVDTRLRDASRAGMTPSQFDSKSRGVLAYRALLKHLLAAQLVPQVA
>NZ_CP014870.1|WP_064679088.1|4885907_4886801_-|flagellar-motor-protein-MotD
MARRRQPEEPVNRERWLVSYADFITLLFAFFVVMYSISSVNEGKYKVISEALIGVFNDADRALQPIPVGDERPKTVTPAKPLVKDSEQIDAGIAQAASDPLKSIADDISAAFGDLISSSQMTVRGNELWVEIELNSSLLFGSGDAMPSDIAFNIIDKVAAILKPFDNPVHVEGFTDDRPIRTAQYPTNWELSSARSASIVRMLAMQGVNPGRLASVGYGEFQPVANNATAEGRARNRRVVLVVSRNLDIRRSLTGTGSANAKPDAALKRAGTQTAPTPIKSPGRESAVNSPSPALIR
>NZ_CP014870.1|WP_064679089.1|4886815_4887556_-|flagellar-motor-protein
MDVLSLIGIIMAFVAIIGGNYLEGGHLGALANGPAALIVIGGTVGAALLQSPMSAFKRALQILVWILFPPRVDLAGGIDRVVGWSLTARKEGLLGLEGVADAEPDSYSRKGLQLLVDGAEPEAIRSILEVDFYTQESRDVEAAKVFESMGGYAPTIGIIGAVMGLIHVMGNLADPSQLGSGIAVAFVATIYGVASANLILLPIAAKLKSVALRQSRYREMLLEGILSIAEGENPRSIELKLHGFMD
>NZ_CP014870.1|WP_064679090.1|4887555_4888701_-|chemotaxis-response-regulator-protein-glutamate-methylesterase
MAVKVLVVDDSGFFRRRVSEILSADPNIQVVGTATNGKEAIDQALALKPDVITMDYEMPMMDGITAVRHIMQRCPTPVLMFSSLTHEGARVTLDALDAGAVDFLPKNFEDISRNPEKVKQLLCEKILSISRSNRRASTYSTYSAPAPVAAPAPAPTPAPSSVSSYGSSAPARPAPAPIPARTPAPASSSPAPRRKAYKLVAIGTSTGGPVALQRVLTQLPANFPAPIVLIQHMPAAFTKAFAERLDKLCRIHVKEAEDGDILRPGLALLAPGGKQMMVDGRGAVKILPGDERLNYRPCVDITFGSAAKSYGDKVLAVVLTGMGADGREGARLLKQSGSSIWAQDEASCVIYGMPMAIVKAELADAVYGLDEIGKHLVEACI
>NZ_CP014870.1|WP_064679091.1|4888751_4891016_-|chemotaxis-protein-CheA
MSFGADEEILQDFLVEAGEILEQLSEQLVELESRPDDADLLNAIFRGFHTVKGGAGFLQLHELVECCHIAENVFDILRKGERRVDSELMDVVLEALDAVNGMFTEVRERSPVTAATPELLAALARLAEPQSTDQAAPAAAVAPVADSPSDDITDNEFEQLLDSLNAVKAQAEAAPCAPAPVSGNAAASDEITDAEFESLLDQLHGKGRFAVDAVVAPAAPAAPATPATPKAAGDSSDITDEEFEALLDQLHGKGNFAVEALESAIASAPVPAAPTAAAVGSDLISDHEFEALLDELHGKGKFSEIGTATGASAPVATPLAKAAAPQSVAKAAEPKAPEPKAEAAKAAPAPVRAPAAPPPEKPASEAETTVRVDTARLDEIMNMVGELVLVRNRLVRLGANSADEAMSKAVSNLDVVTADLQTAVMKTRMQPIKKVFGRFPRLVRDLARQLKKEINLELVGEETDLDKNLVEALADPLVHLVRNAVDHGIESPEEREAAGKSRGGKVILAAEQEGDHILLSISDDGKGMDPNVLRAIAVKRGVMDKDAAERLSDTECYNLIFAPGFSTKTEISDVSGRGVGMDVVKTKISQLNGSINIYSAKGQGSKIVIKVPLTLAIMPTLMVMLANQAFAFPLVNVNEIFHLDLSRTNVVDGQEVVIVRDKALPLFYLKRWLVRSAAHEEQREGHVVILTVGTQRIGFVVDQLVGQEEVVIKPLGKMLQGTPGMSGATITGDGRIALILDVPSMLKRYATRRI
>NZ_CP014870.1|WP_064679092.1|4891039_4891828_-|protein-phosphatase-CheZ
MEHKESSQGDFESTLKKHAVELVESLEKGKFGDAVQLIHELNQTRDRGLYREVGKLTRELHSAIVNFQIDPHMPQAEEVSQITDATERLGYVVRLTEAAANRTMDLVENATPLVNSLSNEAQALSTDWGRFMRREVGAEEFRELARRVDGFLTRSSADNRIVSSNLNDILLAQDYQDLTGQVIKRVTQLVTEVESNLLKLVLMASQVDRFAGIEHDREAMRAEKDPQKQLSQGEGPQIHADKREDVVSGQDDVDDLLSSLGF
>NZ_CP014870.1|WP_162493647.1|4891850_4892222_-|chemotaxis-protein-CheY
MKILIVDDFSTMRRIIKNLLRDLGFTNTVEADDGTTAIPMLNSGSIDFLVTDWNMPGMTGIDLLRHVRADEKLKHLPVLMVTAEAKREQIIEAAQAGVNGYVVKPFTAQALKEKIEKIFERIG
>NZ_CP014870.1|WP_064679094.1|4892389_4893130_-|RNA-polymerase-sigma-factor-FliA
MTASGYNFYKQSARDAQYELIERYAPLVKRIAYHLLARLPASVQVEDLIQAGMIGLLEVSTKYDASKGASFETYAGIRIRGAMLDEVRKGDWAPRSVHRNTRMVSDAIRSIEAKTGRDAKDHEVAAELQLSLDDYYGILNDTLGSRLFSFDDLLQDGEHEGLHEDGASAHPEPSRDLEDDRFQAALADAIANLPERERLVLALYYDEELNLKEIGEVLGVSESRVSQLHSQCAARLRARLGEWRAR
>NZ_CP014870.1|WP_007975361.1|4893126_4893957_-|flagellar-synthesis-regulator-FleN
MGSMHPVQVIAVTGGKGGVGKTNVSVNLSLALAELGRRVMLLDADLGLANVDVLLGLTPKRTLADVIEGRCELRDVLLQGPGGIRIVPAASGTQSMVHLSPAQHAGLIQAFSDIGDNLDVLVIDTAAGIGESVVSFVRAAQEVLLVVCDEPTSITDAYALIKLLNRDYGMNRFRVLANMAQSPQEGRNLFAKLTKVTDRFLDVALQYVGAVPYDESVRKAVQKQRAVYEAFPRSKCSLAFKAIAQKVDTWPLPANPRGHLEFFVERLVQQTAGPVL
>NZ_CP014870.1|WP_064679095.1|4894073_4895405_-|flagellar-biosynthesis-protein-FlhF
MQVKRFFAADMRQAMKLVRDELGADAAIIGNRRIAGGVELTAALDYKLSALAPRVPNMELEDELRKTQSRIVTAQAELSLRSEGESDKATNRQLFAGLPLTAAEPLVEPTYTEPARPAPAPAAVATGGVDPRAFDSMRFELNSLRELMEVQLGSLAWNQLQGSRPAQASLWRRMQRIGLSGPLSRDLLAMIPDIEEPRQAWRMLLAHLARMINTPDIEPLEEGGVIAMVGPAGMGKTTTLAKLAARYVLKYGAQHIALVSMDSYRIGAQEQLKTLGRILNVPVTHVDPGQSLVQALDPLLRKRVVLIDTAGLQASDPALRMQLESLAGRGIKSKNYLVLATTSQKQVLTAAYHSYKRCGLAGCILTKLDETASLGDVLSLAISHDLPVAYLTDGPRIPDDLHLPRRHQLVSRAVSVQMQEEPSEEAMADMFADIYHSPTKQVG

Crispr_ID: NZ_CP014870_16

• CRISPR_ID: NZ_CP014870_16
• CRISPR_location: 5191785-5191857
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_16

Consensus_repeat	Method
TTCGCCGGCAAGCCTGGCTCCTAC	CRISPRCasFinder

spacers of NZ_CP014870_16

>16.1|5191809|25|NZ_CP014870|CRISPRCasFinder
GGGCGAAGGCGTCACTGAAAGCGCG

CRISPR arrays and Neighbor proteins around NZ_CP014870_16

CRISPR arrays

The CRISPR arrays of NZ_CP014870_16

>merge|NZ_CP014870|16|5191785-5191857|CRISPRCasFinder
TTCGCCGGCAAGCCTGGCTCCTACGGGCGAAGGCGTCACTGAAAGCGCGTTCGCCGGCAAGCCTGACTCCTAC

>NZ_CP014870|16|15|5191785-5191857|CRISPRCasFinder
TTCGCCGGCAAGCCTGGCTCCTAC	GGGCGAAGGCGTCACTGAAAGCGCG
TTCGCCGGCAAGCCTGACTCCTAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064679363.1|5200232_5201183_-|glucokinase	unknown	unknown	gnl|CDD|234716
NZ_CP014870.1|WP_064679362.1|5199324_5200056_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NZ_CP014870.1|WP_064679347.1|5182957_5183194_+|DUF3820-family-protein	unknown	unknown	gnl|CDD|378970
NZ_CP014870.1|WP_064679365.1|5203226_5204228_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|223135
NZ_CP014870.1|WP_064679354.1|5189330_5190185_-|D-hexose-6-phosphate-mutarotase	unknown	unknown	gnl|CDD|185697
NZ_CP014870.1|WP_064679346.1|5182286_5182754_-|PA2169-family-four-helix-bundle-protein	unknown	unknown	gnl|CDD|378201
NZ_CP014870.1|WP_064679348.1|5183226_5184408_+|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl|CDD|223594
NZ_CP014870.1|WP_064679361.1|5197865_5199335_-|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|236531
NZ_CP014870.1|WP_064679351.1|5185995_5186709_-|6-phosphogluconolactonase	unknown	unknown	gnl|CDD|238694
NZ_CP014870.1|WP_064679355.1|5190301_5191648_-|porin	unknown	unknown	gnl|CDD|226185
NZ_CP014870.1|WP_178084775.1|5188405_5189266_+|transcriptional-regulator-HexR	unknown	unknown	gnl|CDD|183082
NZ_CP014870.1|WP_064679357.1|5193032_5193878_-|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NZ_CP014870.1|WP_064679359.1|5194946_5196254_-|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|224567
NZ_CP014870.1|WP_064679364.1|5201179_5203006_-|phosphogluconate-dehydratase	unknown	unknown	gnl|CDD|181628
NZ_CP014870.1|WP_064679349.1|5184410_5185136_-|intradiol-ring-cleavage-dioxygenase	unknown	unknown	gnl|CDD|239540
NZ_CP014870.1|WP_064679350.1|5185312_5185978_-|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	unknown	unknown	gnl|CDD|235577
NZ_CP014870.1|WP_064679360.1|5196370_5197630_-|AGE-family-epimerase/isomerase	unknown	unknown	gnl|CDD|369267
NZ_CP014870.1|WP_064679352.1|5186695_5188165_-|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|235579
NZ_CP014870.1|WP_064679356.1|5191868_5193029_-|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	unknown	unknown	gnl|CDD|236947
NZ_CP014870.1|WP_064679358.1|5193870_5194779_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064679363.1|5200232_5201183_-|glucokinase	gnl|CDD|234716	PRK00292, glk, glucokinase; Provisional.	3.38524e-169
NZ_CP014870.1|WP_064679362.1|5199324_5200056_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.57981e-80
NZ_CP014870.1|WP_064679347.1|5182957_5183194_+|DUF3820-family-protein	gnl|CDD|378970	pfam12843, QSregVF_b, Putative quorum-sensing-regulated virulence factor. QSregVF_b is a family of short Pseudomonas proteins that are potential virulence factors. The structure of UniProtKB:Q9HY15 a secreted protein has been solved and deposited as Structure 3npd, from pfam13652. It is predicted that these two adjacent proteins form a single transcriptional unit based on the prediction that together they interact with their adjacent protein PotD, which is the putrescine-binding periplasmic protein in the polyamine uptake system comprising PotABCD. These two adjacent proteins are predicted to be quroum-sensing-regulated virulence factors.	3.7328e-35
NZ_CP014870.1|WP_064679365.1|5203226_5204228_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl|CDD|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	8.00724e-179
NZ_CP014870.1|WP_064679354.1|5189330_5190185_-|D-hexose-6-phosphate-mutarotase	gnl|CDD|185697	cd09020, D-hex-6-P-epi_like, D-hexose-6-phosphate epimerase-like. D-Hexose-6-phosphate epimerase Ymr099c from Saccharomyces cerevisiae belongs to the large superfamily of aldose-1-epimerases. Its active site is very similar to the catalytic site of galactose mutarotase, the best studied member of the superfamily. It also contains the conserved glutamate and histidine residues that have been shown in galactose mutarotase to be critical for catalysis, the glutamate serving as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. In addition Ymr099c contains 2 conserved arginine residues which are involved in phosphate binding, and exhibits hexose-6-phosphate mutarotase activity on glucose-6-P, galactose-6-P and mannose-6-P.	2.54295e-84
NZ_CP014870.1|WP_064679346.1|5182286_5182754_-|PA2169-family-four-helix-bundle-protein	gnl|CDD|378201	pfam09537, DUF2383, Domain of unknown function (DUF2383). Members of this protein family are found mostly in the Proteobacteria, although one member is found in the the marine planctomycete Pirellula sp. strain 1. The function is unknown.	7.57856e-46
NZ_CP014870.1|WP_064679348.1|5183226_5184408_+|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl|CDD|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	1.1585e-55
NZ_CP014870.1|WP_064679361.1|5197865_5199335_-|HAMP-domain-containing-protein	gnl|CDD|236531	PRK09467, envZ, osmolarity sensor protein; Provisional.	4.68391e-47
NZ_CP014870.1|WP_064679351.1|5185995_5186709_-|6-phosphogluconolactonase	gnl|CDD|238694	cd01400, 6PGL, 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.	4.2531e-73
NZ_CP014870.1|WP_064679355.1|5190301_5191648_-|porin	gnl|CDD|226185	COG3659, OprB, Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane].	4.63093e-150
NZ_CP014870.1|WP_178084775.1|5188405_5189266_+|transcriptional-regulator-HexR	gnl|CDD|183082	PRK11302, PRK11302, DNA-binding transcriptional regulator HexR; Provisional.	0
NZ_CP014870.1|WP_064679357.1|5193032_5193878_-|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.04217e-77
NZ_CP014870.1|WP_064679359.1|5194946_5196254_-|carbohydrate-ABC-transporter-substrate-binding-protein	gnl|CDD|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	9.65349e-37
NZ_CP014870.1|WP_064679364.1|5201179_5203006_-|phosphogluconate-dehydratase	gnl|CDD|181628	PRK09054, PRK09054, phosphogluconate dehydratase; Validated.	0
NZ_CP014870.1|WP_064679349.1|5184410_5185136_-|intradiol-ring-cleavage-dioxygenase	gnl|CDD|239540	cd03457, intradiol_dioxygenase_like, Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the extradiol-cleaving enzymes which break the C2-C3 or C1-C6 bond and utilize Fe2+ and Mn+. The family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases. The specific function of this subgroup is unknown.	6.3397e-72
NZ_CP014870.1|WP_064679350.1|5185312_5185978_-|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	gnl|CDD|235577	PRK05718, PRK05718, keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional.	4.21244e-118
NZ_CP014870.1|WP_064679360.1|5196370_5197630_-|AGE-family-epimerase/isomerase	gnl|CDD|369267	pfam07221, GlcNAc_2-epim, N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase). This family contains a number of eukaryotic and bacterial N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) enzymes (EC:5.3.1.8) approximately 500 residues long. This converts N-acyl-D-glucosamine to N-acyl-D-mannosamine.	2.71188e-129
NZ_CP014870.1|WP_064679352.1|5186695_5188165_-|glucose-6-phosphate-dehydrogenase	gnl|CDD|235579	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated.	0
NZ_CP014870.1|WP_064679356.1|5191868_5193029_-|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	gnl|CDD|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	1.33789e-176
NZ_CP014870.1|WP_064679358.1|5193870_5194779_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.70482e-74

Protein sequences

>NZ_CP014870.1|WP_064679355.1|5190301_5191648_-|porin
MKKNNNAQLICQLSAIAAMTLAGSVQAADAFSADSEWMTGDWGGERTRLIEQGIDIKMDYVGEVGGNLHGGYNDDKTARYADQFGLGVALDLQKLWGWDNTQAKFQLTNRNGENISNDRVGDPRAGTLSSSQEVYGRGHMVRLTQLWIKHQFLDNKLDVKAGYFGEGEDFNTFPCEFQNLAFCGSQVGNWATNIWYNWPVMQAAVRVKYNISPEWYAQIGAYNQNPSQLEHGNGFKLSGSGTEGTVLPVELVWLPNPGNLPGEYRVGYYKSTANADDVRKDADGNDAATSGNAYRSHDSKHGYWFVAQQQLTSHNGDASRGLNIAANATFHDKDTNFVDNYQSLMFVYKGPFDARPKDDMGIGFARIHVNDDVKKNAELVNASNGVTEYEDPLFSPLRSTEYNYEINYGFHVTNWLTVRPNLQYITHPGGVDEVDNALVAGLKIQSVF
>NZ_CP014870.1|WP_064679354.1|5189330_5190185_-|D-hexose-6-phosphate-mutarotase
MHEHPLQRFYKSLRKRPVFAWERYQMRDVLVIDHPLCQAVFSRQGAQLLHFQPRDQKPWLWCAAKWPHVGAIRGGVPVCWPWYGRHPSENAWPSHGWARLLDWKLLDSSSDDDGVRLHWQLQLCDWQVDLHAHLGERMELRLCTEHQDSLPCQLSQALHAYWRIGDVGEVALSGLDGAHGYDHLNRQVCQQDGELRVEGGCQRVFQQEGELQLKDHAWQRALCIDTGDDADTVVWHPGSRPLLGVSWNEMGEFVCVEAASGGTDSLSLAPGQKAHLSLQARVGV
>NZ_CP014870.1|WP_178084775.1|5188405_5189266_+|transcriptional-regulator-HexR
MRNLLEQIQNRLEDLNKAERKVAEVILLNPQQATRFSIAALAQASKVSEPTVNRFCRSFGVSGYPELKLQLAQSLASGAAYVSRAVEADDNPEAYTKKIFGSAIASLDSALQALDPNLISRAVDLLIQARQIHFFGLGASAPVALDAQHKFFRFNLAVTAHADVLMQRMIASVAHTGELFVIISYTGRTRELVEVARLARENGASVLGLTAEGSPLAKASTLSLNIPLPEDTDIYMPMTSRIIQLTVLDVLATGMTLRRGVDFQPHLRKIKESLNASRYPIGDEFN
>NZ_CP014870.1|WP_064679352.1|5186695_5188165_-|glucose-6-phosphate-dehydrogenase
MPSITVEPCTFALFGALGDLALRKLFPALYQLDGAGLLHEDTRIIALAREPGSEQQHLAFIAAELRRYVNDKELDEAVVERFLARLSYLHVDFLKADDYVALAERAGSAQRVIAYFATPAAVYGAICENLSKVGLTENTRVVLEKPIGSDLESSRKVNDAVAQFFPENRTYRIDHYLGKETVQNLIALRFANSLFETQWNQNYISHVEITVAEKVGIEGRWGYFDKAGQLRDMIQNHLLQLLCLIAMDPPADLSADSIRDEKVKVLKALAPISPEGLTTQVVRGQYIAGHSEGKSVPGYLEEPNSNTQSDTETFVALRADIRNWRWAGVPFYLRTGKRMPQKLSQIVIHFKEPSHYIFAPEQRLQISNKLIIRLQPDEGISLRVMTKEQGLDKGMQLRSGPLQLNFSDTYRSARIPDAYERLLLEVMRGNQNLFVRKDEIEAAWNWCDQLIAGWKKSGDAPKPYAAGSWGPMSSIALITRDGRSWYGDI
>NZ_CP014870.1|WP_064679351.1|5185995_5186709_-|6-phosphogluconolactonase
MAISELKLPQGVSAHEFKSPVLLAEGLALKVARQLSDAIDARGTATLVVSGGRSPVAFFQHLAKQTLDWSNVVVTLADERWVPVEHADSNAGLLKRYLLQGPAAKAQFLSLYSATANLEQAAEQADRLLGELPPIDVLILGMGDDGHTASLFPNSPNLADALKVDGSRRCWPMLAPTVPHQRLTMSRALLASATNTVLSISGQSKLTTLSAALAGDDVAAMPIRAFLQPTLEIYWCP
>NZ_CP014870.1|WP_064679350.1|5185312_5185978_-|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase
MTNTSPTVSMADKVALIDSLCAKARILPVITIAREQDILPLADALAAGGLTALEVTLRSQFGLKAIQVLREQRPELVTGAGTVLDRRMLAAAEAAGSQFIVTPGITRDLLEASVDSPIPLLPGISNASGIMEGYGLGYRRFKLFPAEVSGGVAAIKALGGPFGEVKFCPTGGVSPANIKSYMALKNVMCVGGSWMLDPEWIKNGDWARIQECTAEALALLD
>NZ_CP014870.1|WP_064679349.1|5184410_5185136_-|intradiol-ring-cleavage-dioxygenase
MDDNTSAVPSTPAYLLSPEQIAGPYFRNPKLIRRNISEGMDGIPLVLRLTVVDATTGRPVPDALVDIWHCNARGAYSGWSKIDPDKEVDVDRIGSIQRTDDDTYLRGGQFTDKKGIVRFTTIYPGFYAGRALHIHVAIRITAGNNYLQERHVAWVGQLYLPEVASRSVLNAREYSGRSVSPLTNGEDFFYETMGGEASTLNVHTLGRDSKEDGFFGQMTIGIDTFAVSTQIKPEDFDKFTV
>NZ_CP014870.1|WP_064679348.1|5183226_5184408_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MPDNTRRARDEAFWLTFADRYAIEPGPVNLENGYFGRMSRTVVEEYQRNIELINRSNSVHARQRFDRDESLEIRAQVAGLVGVCADAVALTRNASDGLQSLIRNYNRLKPGDQVLICDLEYDTVKSAMRWLARYRGVEVIEIEHGHPASFDSLLATYRDAFVRYPRLKLMALTHVTHRTGLVMPVKAIAAAAREHAVDVILDGAHALGQIEFDFEDLGVSFAGYNLHKWIGAPLTLGFIYINPERLADIDPDMGEMHFPTTDIRARTPHSTPNIPALLTLPLVLEEHRTMGGSAAKGARLNYLRNRWVRAVRELSGVEVMTPDDPRLYCGITSVRFTRHADQQAMAERLLKDYNLFTIARSGAASGPCIRITPGLTTTAADIDLLIRALNELR
>NZ_CP014870.1|WP_064679347.1|5182957_5183194_+|DUF3820-family-protein
MNPEKLELLVTREMPFGKYKGRIIADLPGQYLNWFAREGFPRGELGGLLALMQEIDHNGLSELLEPLRAKHGKPAPRH
>NZ_CP014870.1|WP_064679346.1|5182286_5182754_-|PA2169-family-four-helix-bundle-protein
MTDMNKEAISVLNDLIETSKDGQEGFKTCAEDIKNPELKTLFVQRSADCAAAAAELQAAVRSMGGDPETSTSVSGDLHRRWVDVKSMFTGKDEEAVLNEAERGEDHALKAYKEALEKITKHNLVGIRDVVERQYHGVQRNHDQVKALRNQARARS
>NZ_CP014870.1|WP_064679356.1|5191868_5193029_-|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC
MATLELRNVNKTYGAGLPDTLKNIELKIDDGEFLILVGPSGCGKSTLMNCIAGLENISGGAILVDDADISGMSPKDRDIAMVFQSYALYPTMSVRDNIAFGLKIRKMPAAEIDEEVARVAKLLQIEHLLSRKPGQLSGGQQQRVAMGRALARRPKIYLFDEPLSNLDAKLRVEMRTEMKLMHQRLKTTTVYVTHDQIEAMTLGDKVAVMKDGIIQQFGTPKDIYNNPANLFVASFIGSPPMNFIPLRLQRKDGRLVALLDSGQARCELPLGMQDAGLEDREVILGMRPEQIVLAGSEPNGLPTIRAEVQVTEPTGPDTLVFVNLNETKVCCRLAPDVAPAVGETLTLQFDPSKVLLFDAKTGERLGVAVLPKTEAHTANVAQFKGR
>NZ_CP014870.1|WP_064679357.1|5193032_5193878_-|carbohydrate-ABC-transporter-permease
MSNQLGKPALSFSRVAIYATLLLAAAVYLIPLVVMLLTSFKTPEDIRTGNLLSWPQVIDGIGWIKAWDSVGSYFWNSVKITVPAVLISTFIGAMNGYVLSMWRFRGSQLFFGLLLFGCFLPFQTVLLPASFTLGKIGLANTTTGLVLVHVVYGLAFTTLFFRNYYVSIPDALVKAARLDGAGFFTIFWKILLPMSIPIVMVCLIWQFTQIWNDFLFGVVFASGDAQPITVALNNLVNTSTGAKEYNVDMAAAMIAGLPTLLVYIFAGKYFLRGLTSGAVKG
>NZ_CP014870.1|WP_064679358.1|5193870_5194779_-|sugar-ABC-transporter-permease
MSSVAVFSKASPFDALQRWLPKLVLAPSMLIVLVGFYGYIIWTFVLSFTNSSFMPSYKWVGLQQYIRLMDNDRWWVASKNLALFGGMFIGISLVLGVFLAVLLDQRIRKEGFIRTVYLYPMALSMIVTGTAWKWLLNPGLGLDKMLRDWGWEGFRLDWLVDQDRVVYCLVIAAVWQASGFVMAMFLAGLRGVDQSIIRAAQVDGASLPTIYLKIVLPSLRPVFFSAFMILAHIAIKSFDLVAAMTAGGPGYSSDLPAMFMYSFTFSRGQMGIGSASAMMMLGAILAILVPYLYSELRGKRHE
>NZ_CP014870.1|WP_064679359.1|5194946_5196254_-|carbohydrate-ABC-transporter-substrate-binding-protein
MNAISRLATVISLASLLPLSAFPLSALAADAKGSVEVVHWWTSGGEKAAVDVLKAQVEKDGFTWKDGAVAGGGGSTAMTVLKSRAVAGNPPGVAQIKGPDIQEWGSTGLLSTDALKDVSKSENWDGLLPAKVSDTVKYEGDYVAVPVNIHRVNWLWINPQVFKKAGIDKAPTTLEEFYAAGDKLKAAGFIALAHGGQPWQDSTVFEDVVLSVMGADGYKKALVDLDQKTLSGAEMTKAFTELKKLTGYMDPNRAGRDWNIAAADVINGKAGMQMMGDWAKSEWTAAKKVAGKDYECVPFPGTEKAFTYNIDSLAVFKLKADRKGDIAAQQDLAKVALGKDFQKIFSINKGSIPVRTDMLNDMSGLGFDACAQAAAKDFLADEKTGGLQPSMAHNMATSLAVQGAIFDVVTNFMNDKNADPAKASAQLASAVKAAQ
>NZ_CP014870.1|WP_064679360.1|5196370_5197630_-|AGE-family-epimerase/isomerase
MDTFQPAFSSWLNAPAHQQWLAAEGLRLLAFAKAAKLPEGFGNLDEKGRLPANARAETMNTARMTHSFAMAHIQGLPGFAELVDHGVKALGGPLRDAGHGGWFATAHHRDGDTGKAAYLHAFVALAASSAVVAQRPGALALLDDAIHIIDTYFWSEEEGAMRESFNRDWHVEEAYRGANSNMHATEAFLALADVTRDNRWLVRAQRIVERVIHTHAAANDFLVVEHFDRDWQPLLEYNHDHPADGFRPYGTTPGHGFEWARLLLHLEAARVRAGMPAPGWLATDAQKLFDNNCRDGWNVDGAPGIVYTLDWDNRAVVRHRLHWTHCEASAAASALLKRTGDERYEHWYRLFWEFCDSHFIDRRDGSWYHELDPQNRPSADIWAGKPDLYHAWQAVLIPRLPLAPSMATALGQLSQSAPV
>NZ_CP014870.1|WP_064679361.1|5197865_5199335_-|HAMP-domain-containing-protein
MATEFFRQLAAKVPVPRSLLGRMLLLTLLAVLFAQALSSVIWVSQLRATQLEGLVTSARSLAHSMTASVSYFRSLPVAFRPLVLDQLRSMGGTRFVVTLNDKPLGMEVLPITPRKAAVLKAVDEVLRQSLGQDTDISVTFVSPEDLRIFNGGLKLDELPRSWAHYALTLEPVNPPVLVTQIQMAPGEWLYIASLLPEPYTSLEEQGLPAQQVWFIVLTSGFLLLFIGLLVHWQSRPLKRLARAARDMSLGAEVEPVAEGGGSEVVEVGRAFNAMRERISRYLTERSQLFSAISHDLRTPITRLRLRVELLEDEQLQAKFGRDLDELELLVKGALQCVKDTDIHENIEPVDLNHVLDCLVEPYLAPNGNGRVTQQGRALAPYPGKPLALKRCIGNLIDNALKYGQNAHLHIDDDDSAFVLHVDDEGPGVPEQRLEQVFEPHFRLAGQQQGYGLGLGIARNIAHSHGGEVSLQNLREGGLRVTLQLPRSID
>NZ_CP014870.1|WP_064679362.1|5199324_5200056_-|response-regulator-transcription-factor
MSSVNKSILLVDDDQEIRELLDTYLTRAGFQVRTTPDGAGFRQAMNEAPSDLVILDVMLPDEDGFSLCRWIRQHPRQAQVPIIMLTASSDEADRVIGLELGADDYLGKPFSPRELQARIKALLRRAQFGQERSGGEVLAFDDWRLDMVSHRLFHIDGEEVILSGADFALLKLFLDHPQEILDRDTIGNATRGRDLMPLDRIVDMAVSRLRQRLRDTEKPPRLIRTVRGSGYQLAATVVASNGH
>NZ_CP014870.1|WP_064679363.1|5200232_5201183_-|glucokinase
MKLALVGDIGGTNARFALWKNQQLESIQVLATADHASPIDAIGLYLSGLGLAPGSIGSVCLSVAGPVSGDEFKFTNNHWRLGRKEFCEILQVDQLLLVNDFSAMALGMTRLQPGEFRVVCEGTPEPLRPAVVIGPGTGLGVGTLLDLGEGRFAALPGEGGHVDLPLSSLRETQLWQHIFNEIGHVSAETALSGSGLPRVYRAICAVDGHEAVLDTPESITAAGLAGDPIALEVLEQFCCWLGRVAGNNVLTTGARGGVYIVGGVIPRFADFFIESGFARCFADKGCMSDYFKGIPVWLVTAPYPGLMGAGVALDQA
>NZ_CP014870.1|WP_064679364.1|5201179_5203006_-|phosphogluconate-dehydratase
MHPRVLEVTERLIARSRATREAYLALIRGAASDGPMRGKLQCANFAHGVAGCGSDDKHSLRMMNAANIAIVSSYNDMLSAHQPYEVFPEQIKKALREIGSVGQFAGGTPAMCDGVTQGEPGMELSLPSREVIALSTAVALSHNMFDGALMLGICDKIVPGLMMGALRFGHLPTIFVPGGPMVSGISNKQKADVRQRYAEGKATREELLESEMKSYHSPGTCTFYGTANTNQLLMEVMGLHLPGASFVNPNTPLRDALTREAAHQVTRLTKQNGNFMPIGEIVDERSLVNSIVALHATGGSTNHTLHMPAIAMAAGIQLTWQDMADLSEVVPTLSHVYPNGKADINHFQAAGGMSFLIRELLEAGLLHENVNTVLGHGLSRYTMEPFLDNGELVWREGPIESLDEAILRPVARAFSPEGGLRVMEGNLGRGVMKVSAVALENQVVEAPAMVFQDQQDLADAFKAGLLEKDFVAVMRFQGPRSNGMPELHKMTPFLGVLQDRGFKVALVTDGRMSGASGKIPAAIHVSPEAYVGGALARVQEGDIIRVDGVTGTLELKVDAEEFAAREPAKGLLANNIGSGRELFGFMRMAFSSAEQGASAFTSALETLN
>NZ_CP014870.1|WP_064679365.1|5203226_5204228_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MTLRIAINGFGRIGRNVLRALYTQGYRQDLQIVAINDLGDSAMNAHLLKYDTVHGTFDAQVQHDQESLTVNGDRISVSAIRNPAELPWAAEKIDVVFECTGLFTDREKAAAHITAGARKVIISAPAKGADATVVYGVNHDILRQSHQIISNASCTTNCLAPVAQVLHRELGIESGLMTTIHAYTNDQNLTDVYHSDPYRARSATQNMIPSKTGAAEAVGLVLPELAGKLTGMAVRVPVINVSLVDLTVQLKREASAAEVNALLKEASRHSKILGYNTLPLVSSDFNHNPLSSIFDANHTKSSGKLLKVLAWYDNEWGFSNRMLDNCLALCNAE

Crispr_ID: NZ_CP014870_17

• CRISPR_ID: NZ_CP014870_17
• CRISPR_location: 5362331-5362419
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP014870_17

Consensus_repeat	Method
CTTCGCCAGCAAGCCGGCTCCTACAA	CRISPRCasFinder

spacers of NZ_CP014870_17

>17.1|5362357|37|NZ_CP014870|CRISPRCasFinder
AAGCGGAAACGGTTTGTCTGGCACACCGCGTCGTCTG

CRISPR arrays and Neighbor proteins around NZ_CP014870_17

CRISPR arrays

The CRISPR arrays of NZ_CP014870_17

>merge|NZ_CP014870|17|5362331-5362419|CRISPRCasFinder
CTTCGCCAGCAAGCCGGCTCCTACAAAAGCGGAAACGGTTTGTCTGGCACACCGCGTCGTCTGCTTCGCCAGCAAGCCGGCTCCTACAA

>NZ_CP014870|17|16|5362331-5362419|CRISPRCasFinder
CTTCGCCAGCAAGCCGGCTCCTACAA	AAGCGGAAACGGTTTGTCTGGCACACCGCGTCGTCTG
CTTCGCCAGCAAGCCGGCTCCTACAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP014870.1|WP_064679488.1|5352571_5353042_-|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl|CDD|237976
NZ_CP014870.1|WP_064679490.1|5354332_5355838_+|glycerol-kinase-GlpK	unknown	unknown	gnl|CDD|234594
NZ_CP014870.1|WP_064679495.1|5362453_5364355_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226654
NZ_CP014870.1|WP_064679501.1|5376784_5377423_-|LysE-family-translocator	unknown	unknown	gnl|CDD|224199
NZ_CP014870.1|WP_162493658.1|5365860_5366877_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP014870.1|WP_064679493.1|5360848_5361520_+|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|185062
NZ_CP014870.1|WP_064680793.1|5376284_5376782_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP014870.1|WP_064679498.1|5367099_5372766_+|hypothetical-protein	unknown	unknown	gnl|CDD|274009
NZ_CP014870.1|WP_064679500.1|5375320_5376238_+|transcriptional-regulator-MetR	unknown	unknown	gnl|CDD|176132
NZ_CP014870.1|WP_007916700.1|5355933_5356689_+|DeoR/GlpR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|182827
NZ_CP014870.1|WP_064679496.1|5364351_5365680_+|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225114
NZ_CP014870.1|WP_064679491.1|5357013_5358552_+|glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|237027
NZ_CP014870.1|WP_064679494.1|5361516_5362251_+|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224051
NZ_CP014870.1|WP_064679487.1|5351682_5352465_-|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl|CDD|223461
NZ_CP014870.1|WP_064679499.1|5372889_5375202_-|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	unknown	unknown	gnl|CDD|235367
NZ_CP014870.1|WP_064679489.1|5353404_5354256_+|aquaporin	unknown	unknown	gnl|CDD|238204
NZ_CP014870.1|WP_064680792.1|5358995_5359910_+|glutamate/aspartate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|236763
NZ_CP014870.1|WP_064679502.1|5377445_5377877_-|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|240046
NZ_CP014870.1|WP_064679503.1|5378092_5379472_-|response-regulator	unknown	unknown	gnl|CDD|225971
NZ_CP014870.1|WP_064679492.1|5360102_5360849_+|amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|223836

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP014870.1|WP_064679488.1|5352571_5353042_-|Cys-tRNA(Pro)-deacylase	gnl|CDD|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	9.42802e-79
NZ_CP014870.1|WP_064679490.1|5354332_5355838_+|glycerol-kinase-GlpK	gnl|CDD|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NZ_CP014870.1|WP_064679495.1|5362453_5364355_+|sensor-histidine-kinase	gnl|CDD|226654	COG4191, COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms].	0
NZ_CP014870.1|WP_064679501.1|5376784_5377423_-|LysE-family-translocator	gnl|CDD|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.04611e-46
NZ_CP014870.1|WP_162493658.1|5365860_5366877_-|alpha/beta-fold-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.2445e-23
NZ_CP014870.1|WP_064679493.1|5360848_5361520_+|ABC-transporter-permease-subunit	gnl|CDD|185062	PRK15107, PRK15107, glutamate/aspartate ABC transporter permease GltK.	4.11513e-75
NZ_CP014870.1|WP_064680793.1|5376284_5376782_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.52747e-13
NZ_CP014870.1|WP_064679498.1|5367099_5372766_+|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00234938
NZ_CP014870.1|WP_064679500.1|5375320_5376238_+|transcriptional-regulator-MetR	gnl|CDD|176132	cd08441, PBP2_MetR, The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold. MetR, a member of the LysR family, is a positive regulator for the metA, metE, metF, and metH genes. The sulfur-containing amino acid methionine is the universal initiator of protein synthesis in all known organisms and its derivative S-adenosylmethionine (SAM) and autoinducer-2 (AI-2) are involved in various cellular processes. SAM plays a central role as methyl donor in methylation reactions, which are essential for the biosynthesis of phospholipids, proteins, DNA and RNA. The interspecies signaling molecule AI-2 is involved in cell-cell communication process (quorum sensing) and gene regulation in bacteria. Although methionine biosynthetic enzymes and metabolic pathways are well conserved in bacteria, the regulation of methionine biosynthesis involves various regulatory mechanisms. In Escherichia coli and Salmonella enterica serovar Typhimurium, MetJ and MetR regulate the expression of methionine biosynthetic genes. The MetJ repressor negatively regulates the E. coli met genes, except for metH. Several of these genes are also under the positive control of MetR with homocysteine as a co-inducer. In Bacillus subtilis, the met genes are controlled by S-box termination-antitermination system. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.78299e-123
NZ_CP014870.1|WP_007916700.1|5355933_5356689_+|DeoR/GlpR-family-transcriptional-regulator	gnl|CDD|182827	PRK10906, PRK10906, DeoR/GlpR family transcriptional regulator.	6.68505e-108
NZ_CP014870.1|WP_064679496.1|5364351_5365680_+|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl|CDD|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NZ_CP014870.1|WP_064679491.1|5357013_5358552_+|glycerol-3-phosphate-dehydrogenase	gnl|CDD|237027	PRK12266, glpD, glycerol-3-phosphate dehydrogenase; Reviewed.	0
NZ_CP014870.1|WP_064679494.1|5361516_5362251_+|amino-acid-ABC-transporter-ATP-binding-protein	gnl|CDD|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.22899e-156
NZ_CP014870.1|WP_064679487.1|5351682_5352465_-|PhzF-family-phenazine-biosynthesis-protein	gnl|CDD|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	4.18853e-84
NZ_CP014870.1|WP_064679499.1|5372889_5375202_-|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	gnl|CDD|235367	PRK05222, PRK05222, 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional.	0
NZ_CP014870.1|WP_064679489.1|5353404_5354256_+|aquaporin	gnl|CDD|238204	cd00333, MIP, Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.	1.8866e-74
NZ_CP014870.1|WP_064680792.1|5358995_5359910_+|glutamate/aspartate-ABC-transporter-substrate-binding-protein	gnl|CDD|236763	PRK10797, PRK10797, glutamate and aspartate transporter subunit; Provisional.	2.47799e-137
NZ_CP014870.1|WP_064679502.1|5377445_5377877_-|NUDIX-domain-containing-protein	gnl|CDD|240046	cd04690, Nudix_Hydrolase_31, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	8.29756e-49
NZ_CP014870.1|WP_064679503.1|5378092_5379472_-|response-regulator	gnl|CDD|225971	COG3437, COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms].	4.22163e-91
NZ_CP014870.1|WP_064679492.1|5360102_5360849_+|amino-acid-ABC-transporter-permease	gnl|CDD|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.814e-74

Protein sequences

>NZ_CP014870.1|WP_064679494.1|5361516_5362251_+|amino-acid-ABC-transporter-ATP-binding-protein
MISIKNVNKWYGDFQVLTDCSTEVKKGEVIVVCGPSGSGKSTLIKCVNALEPFQKGDVVVDGTSIADPKTDLPKLRSRVGMVFQHFELFPHLSIMDNLTIAQIKVLGRSKDEASKKALQLLERVGLSAHAKKHPGQLSGGQQQRVAIARALAMDPIVMLFDEPTSALDPEMVNEVLDVMVQLAHEGMTMMCVTHEMGFARKVADRVIFMDQGKIIEDCKKEEFFGDINARAERTQHFLAKILQH
>NZ_CP014870.1|WP_064679493.1|5360848_5361520_+|ABC-transporter-permease-subunit
MEFDFSGIIPSLPGLWNGMVMTLQLMALGVVGGIILGTILALMRLSHSKLLSNIAGAYVNYFRSIPLLLVITWFYLAVPFVLRWITGEDTPIGAFASCIVAFMMFEAAYFCEIVRAGVQSIPKGQMGAAQALGMNYSQMMRLIILPQAFRKMTPLLLQQSIILFQDTSLVYAVGLVDFLNASRASGDIIGRSNEFLIFAGFTYFIISFAASQLVKRLQKRFAV
>NZ_CP014870.1|WP_064679492.1|5360102_5360849_+|amino-acid-ABC-transporter-permease
MNYNWDWGVFFKSTGVGSEIYFDWYLSGLGWTIAIAVAAWIIALLLGSILGVMRTVPNRIVSGIATCYVELFRNVPLLVQLFIWYFLVPDLLPQNLQDWYKQDLNPTTSAFLSVVVCLGLFTSARVCEQVRTGIQALPRGQESAARAMGFKLPQIYWNVLLPQAYRIIIPPLTSEFLNVFKNSSVASLIGLMELLAQTKQTAEFSANLFEAFTLATLIYFTLNMGLMLLMRGVEKKVAVPGLISVGGK
>NZ_CP014870.1|WP_064680792.1|5358995_5359910_+|glutamate/aspartate-ABC-transporter-substrate-binding-protein
MRIVPHILGAAIAAALISTPVFAAELTGTLKKIKESGTITLGHRDASIPFSYIADASGKPVGYSHDIQLKIVEAIKKDLDMPNLQVKYNLVTSQTRIPLVQNGTVDVECGSTTNNVERQQQVDFSVGIFEVGTRLLSKANSEYKDFDNLKGKNVVTTAGTTSERILKSMNADKQMGMNVISAKDHGESFQMLETGRAVAFMMDDALLAGEMAKAKKPADWSVTGTAQSYEIYGCMVRKGDAPFKKAVDDAIIATYKSGEINKIYEKWFMQPIPPKNLNLNFPMSDKIKELIANPTDKAADEKKS
>NZ_CP014870.1|WP_064679491.1|5357013_5358552_+|glycerol-3-phosphate-dehydrogenase
MPTSTLPTPPLAEVYDIAVIGGGINGVGIAADAAGRGLSVFLCEKDDLASHTSSASSKLIHGGLRYLEHYEFRLVREALAEREVLLAKAPHIVKQMRFVLPHRPHLRPAWMIRAGLFLYDHLGKREKLEGSKSLKFGPDSPLKSEITKGFEYSDCWVDDARLVVLNAMAAREKGAHVHTQTRCVSARRTKGLWHLHLERADGSLFSIRAKALVNAAGPWVAKFIRDDLKMESPYGIRLIQGSHLIVPKLYEGEHAHILQNEDQRIVFTIPYLNHFTLIGTTDREYTGDPAKVAITEGETDYLLKVVNAHFKKRISRDDILHSYSGVRPLCNDESDNPSAVTRDYTLALSGTGEEAPLLSVFGGKLTTYRKLAESALAQLAPYFSQIKPSWTATATLPGGEDMTTPQALCAKIRDTFDWVPTEIARRWATTYGSRTWRMLEGVQSLTDLGEHIGGGLYTREVDYLCSEEWATTAHDILWRRSKLGLFTTPAEQQKLADYLSKVEQNRSKIEAA
>NZ_CP014870.1|WP_007916700.1|5355933_5356689_+|DeoR/GlpR-family-transcriptional-regulator
MNLPPRQQQILELVRERGYVSIEEMATLFVVTPQTIRRDINQLAEANLLRRYHGGAAYDSSVENTAYAMRADQMRDEKQRIGEAIAAQIPDHASLFINIGTTTESIARALLNHNHLKIITNNLHVASMLSAKDDFDVLLTGGNVRRDGGVVGQASVDFINQFKVDFALVGISGIDEDGSLLDFDYQEVRVSQAIIANARQVILAADSSKFGRNAMIRLGPISLIDCLVTDQQPVPALAQLLSQHKIRLEVV
>NZ_CP014870.1|WP_064679490.1|5354332_5355838_+|glycerol-kinase-GlpK
MTDIQNKNYIIALDQGTTSSRAIIFDRDANVVCTAQREFVQHYPQPGWVEHDPMEIFATQSAVMVEALAQAGLHHDQVAAIGITNQRETTVVWDKITGRPIYNAIVWQCRRSTEICQQLKRDGHEQYINDTTGLVTDPYFSGTKLKWILDNVEGSRERARKGELLFGTVDSWLIWKFTGGKVHVTDYTNASRTLLFNIHTLEWDAKMLEVLDIPREMLPDVKSSSEIYGHTKSGIAIGGIAGDQQAALFGQMCVEPGQAKNTYGTGCFLLMNTGDKAVKSKHGMLTTIACGPRGEVAYALEGAVFNGGSTVQWLRDELKVINDAHDTEYFANKVKDSNGVYLVPAFTGLGAPYWDPYARGALFGLTRGVRVDHIIRAALESIAYQTRDVLDAMQQDSGERLKSLRVDGGAVANNFLMQFQADILGTQVERPQMRETTALGAAYLAGLACGFWGSLDELRGKAVIERQFEPTLEESAKEKLYAGWKKAVSRTRDWEPHEGAE
>NZ_CP014870.1|WP_064679489.1|5353404_5354256_+|aquaporin
MTTALQQPSLSSQCMAEFLGTALLIFFGTGCVAALKVAGASFGLWEISIIWGIGVSMAIYLTAGVSGAHLNPAVSIALSIFADFEKRKLPFYMLAQIAGAFCGALLVYTLYSGLFFDYEQTHHMVRGTQASLELASVFSTFPNPVLTTAQAFLVEVIITAILMGVIMSLTDDNNGLPKGPLAPLLIGLLIAVIGSSMGPLTGFAMNPARDFGPKLMTFFAGWGEISLTGGRDIPYFLIPIFAPIVGACLGAGAYRGLIARHLPSPMPGTTDAAPAIDGKPRTS
>NZ_CP014870.1|WP_064679488.1|5352571_5353042_-|Cys-tRNA(Pro)-deacylase
MTPALDLLKKVRAEHRVHSYEHDPKAASYGLEAAEKLGLDPAQVFKTLLAASEKGELLVAVVPVVGSLDLKGLAHAAGVKKVEMADPAAAQRSTGYLLGGISPLGQKKRLRTFIDKSAQPFASIFVSAGRRGLEVELAPAVLAEHTRAQFADIGRA
>NZ_CP014870.1|WP_064679487.1|5351682_5352465_-|PhzF-family-phenazine-biosynthesis-protein
MQLEFHQVDAFSDRLFSGNPAMVYRLDAWLADELMQKIAAEHNLAETAFVVREGQHWHIRWFTPSTEVPLCGHATLAGAYVLFEIYREPVERLDFICKSGPLSVSREGRRLWLDFPAIFPSEVGVTLDVERALGVEAVDVLGSNELFVVLESEQAVLDCQPDMVALAKLPWLGAIVTARGNKHDFVSRYFAPAIGINEDPVTGSTHCSLIPYWSKRLGKSDLTAYQCSARGGQLFCRLEGGRVKIGGDATLVASGTLILG
>NZ_CP014870.1|WP_064679495.1|5362453_5364355_+|sensor-histidine-kinase
MKCDPTLYRAAPPSLAVKPRLIRHLFLPPLVIALMIGLGYLGFWISEHYGIRSLSENGQRQLELHARAVESEISKYTYLPSLLELESSVSRLLADPSAEHRQTVNEYLEGLNRRSRSRAIYVMDTTGRVMATSNWRDVDSYLGEDLSFRAYFQNAVRGQPGRFYGIGSTSGEPGYYLAHGLEERGKIIGVAVVKVRLEAMEERWQRARLEAFVSDENGIIILSSDPARRLKSVIPLSEQTKEKLARSLQYYWFPLNELQPLAREKLAEGEEKLTFPANSELESEEENISYLSQTRPLSDTPWNFTLLTPLQDLRREAINQGILVAVAFALVAFLLIAWNERRKVIATRLAAREALQEANNQLERRITERTTDLRASNERLKGQIRERRQAEETLRRAQDELVQAGKLAAIGQMSTSIAHELNQPLAALRTLSGNTVRFLERGQLDVASTNLKTINELIDRMGRITASLRSFARRGDDKGQASVGKAVDAALQVLGSRVEGAHLQLHSDFADRQVQIDQTRLEQILVNLIGNALDAMQAQPLPELWLEGEVFDGKYRLRVRDNGHGIDAEARKHLFEPFFTTKPGEQGLGLGLTLSASLAAATGGHLGVEHPASGGTTFVLSLPLVSPLHAEPI
>NZ_CP014870.1|WP_064679496.1|5364351_5365680_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MNNDLSVLIVEDDPHVLLGCQQALTLEDIPCVGVGSAEEALERVGDNFAGIVISDIRLPGIDGMELLTRLKARDRSLPVVLITGHGDISMAVGAMQKGAYDFMEKPFSPERLVDVARRALEQRSLAREVSSLRRQLAERDSLEGRIIGRSPAMQNLRELIANVADTSANVLIEGETGTGKELVARCLHDFSRRHTKQFVALNCGGLPENLFESEIFGHEANAFTGAGKRRIGKIEHADGGTLFLDEVESMPLPLQIKLLRVLQERTLERLGSNQSVAVDCRVIAATKSDLDESSKAGEFRSDLYYRLNVVTLELPPLRERREDILQLFEHFLQQSSLRFDRVMPELDNQTLSNLMSHDWPGNVRELRNVAERFALGLPAFKKSGNSGNNQGLAFAEAVEAFERNLLVDALQRSGGNLTQASQELGMAKTTLFDKVKKYGLSH
>NZ_CP014870.1|WP_162493658.1|5365860_5366877_-|alpha/beta-fold-hydrolase
MSAAVFLAALFSLPSLAASRCEVNVPTERVDLAQVSLAYQSIGRASDPALLLVMGLGGQLIHWPDEVVVALCQQGFRVIRYDNRDVGLSTWRQTPVDANLTFEVLRYKLGLPVAAPYTLTDMADDAFGLMDALRVEQFHVLGASMGGMIAQHMAAMAPKRVESLTLIMTSSGAEGLPAPSAALVQLLSRRSAPNREVALEQQADLLAALGSPTVSDDRQALLDQAAQSYDRAFNPQGVERQIMAILAEPSRVTLLNRLRVPTLVVHGTADPLLPVMHGVHLAAHIRGSRLKLIPGLAHRFQEAFKAPLLGAVLPYLQAHREDTSHWAQIDPLPAPNLL
>NZ_CP014870.1|WP_064679498.1|5367099_5372766_+|hypothetical-protein
MTERLLFDDPFASPTVLPSFSPLPSLPDESLFLKACARWRESSQGLRELMADSPGIRDTLEQRLKQQLDLGGQHAGLLFAATDQQPQRFVSFTQACAFVLQHPTLETTLDQDCTVTGLNQSHALSSLTPLQILERLKTLDPVQAHSERWTTFWEQRAPGTAVSRKERATQLYRQHFEAAAHLALARKSLTAEQFKPLQLLLDPPVGALTLDNQPVHTEQLALILSNGSRIKPKGAWVISVGDPATVAQWLYLPSRPVAIQRFDTRSDMETWLSRQTLVPTGLPTDNIRYEYTVSTDPMTVGASELFADRSQSQVTSLRHGTPGQSGLAAHGAQSLVQADRIDQQRSHLTVFASPPKLEAADGSTGTDQASLFGSLYADIPWSLRQAALKQQRDALETLVEEVGESAALQQIKASLGALETAEQAADKAASGLLNRSRVADLVTFQSEFTALHSAHKTGLHAEAALQLALKQLDEDEYTLLKALLDTPDDPGPDAVAASVTLSMSQQDGDKTTLNTQELNGVFIVTHADALADANAPHSVLLYWIGTGGGLQRFANRRELERQIFKIHDQNNGLTVRAKKITGDALLYGLDQLTSDFEEQAGAIRQRHAAATADAQRDEQLDILRKRALATLQVPVHAARGLALAHLLEQNRSGTLASNLPDWLGKLSQADRTGLKSLVEAYIVAMRQSHALMTIALEPRDDFTRKHLHARLSKDFSLKGHFDVHLQLPDSVSWEKQYSSTPTGVQENSVMVPGTKSSQMSLADLAQLNIDNVKSVQQDPLSQRLVFMQLQVTAANRKERNALLSGINLTYLRKTLPDLDLPKVYEQLIRDAFVGKFSEPAFVKEHRRESLIEPWRLMLKLQAECARLQKQLGSDALSVLNIAIDANTADAWRADNKRIVMLAAYLGVGGKDTPNNGPVSLSGVTFIEEQVSGLTLLYLPDSPDGQFVRRYDSLEAARKGLYNLCGNDKWVSYLAGRALQGNVRSHVSRINQAVEKYFDAVIGIGERWPATTSLAAHLLDAHMGRLIEAHRDTSRSNDALYMERYALKGPRAFNYIKMAMGMVPFVGTVLALYDAWTAANQATAAFLRGEVGDGLAELKSMLLSLIDAAMDLLPGEAITSQLSRTARTLTRTRQAHQLLSNVAALQGVSLREARHIVKRFSGYEYEKPISLSALQPGDQGLYRGIYRHADGNFIVRQGRIFQVELRDARSWRLYGNSRKTYKQPIALDETGHWDTWYGVYGTTLEGGVLGGGQVFGRLADALDPVWPLVIRERLPSWWADRVVRRTGQLENTSNDLRRLYNTHGPQTNAAITKFNETNEAYTLARGKNPATGAPLRPLTEAQRTDLSKLAQAADTRCVRDIELSIQRYKASEELRGLASGDTRNQAIRAQNECAWVAADRFHLRIFFAGKRIESLADEAADLSRKLDNLPEGSGQYFVVREEVRKIRIKIVSEQDQIEELIEQAKQWFRKITPPQKNAKTPTSDQINFEELREKIEYSSQASGLNAEVVKTGHLLEIMKRVDITSDRSWLDLQQQTKSLRVKFEEAVFTHYDLPEVRATRRERERMLRDCLTVYTQFHRELQAWSTSFPQHFHLEAIDPLLTTINKLAERAREGIAKPTVAKPIRQSTKKIFTTEDDRLLIGTERWENTTQKRQYVMSGLGGTEIVLEQGSNGKFRLLNPPAEAPVPTQIDLATLVSDAEKRMKDLPSHQARVQQYAKPASAPVEQEEMMTFEADVLTRIALQIETLDAANPTIRKLRTKAAEHRREGRKMRTAHSLVNTNPTDGMLDDLIGQNAVEIRKRAPIQNLTKPKKRTDYMQEYEVWDITQTSPELLWYAHFHYTTATPAFRTFEKGHLKLKKHRGLTHADDPSLPLGDIGKKSVVLPHFENL
>NZ_CP014870.1|WP_064679499.1|5372889_5375202_-|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase
MALAHTLGFPRIGADRELKKALEAYWKGDLDQDALKSVGRQLRANHWQVQQDAGIDLLPVGDFAWYDQVLTHSLTFGVVPERFDSTRNERGLPTLDTLFAMARGATASCCGGEHATAQYAQELTKWFDTNYHYLVPEFSVDQQFKLSWEQLFDEVDEAKALGHNVKPVIIGPLTYLWLGKAKGDDFDKLDLLERLLPVYNEILGRLAGQGVEWVQIDEPILTLDLPQDWKNAFERAYHILQYSPLKKLVATYFSGLQDNLGLAVGLPVQGLHIDAVRAPDQLLHVLDRLPTYKTLSVGLVNGRNVWRCELEPVLAQLQFAQERFGDNLWVSSSCSLLHSPVDLEREDKLDPELKSWLAFAVQKCGEISVLRDALNDPQSPKVQAALAESRAVQASRAESPRIHKAEVQARINAIGAADSQRHTPFAERIEQQRARLKLPAFPTTTIGSFPQTASIRLARQAFKQGKLSANDYTDAMHSEIRHAVQVQERLGLDVLVHGEAERNDMVEYFAEQLDGYAFTRFGWVQSYGSRCVKPAIIYGDLSRPAAMTVDWITYAQGLTDKVMKGMLTGPVTMLMWSFPREDVSRKIQAQQLALALRDEVLDLEAAGIKIVQIDEAAFREGLPLRQAQWQEYLDWAVEAFRLTASGVRDETQIHTHMCYSEFNDVIKAIAAMDADVITIETSRSDMELLEAFKAFDYPNDIGPGVYDIHSPRVPDTAEMVKLMTKAVKRIPAQRLWVNPDCGLKTRAWPETEAALVNMVAAARQLRSQLA
>NZ_CP014870.1|WP_064679500.1|5375320_5376238_+|transcriptional-regulator-MetR
MLEIRHLKTLHALREADSLVDAADRLHLTQSALSHQFKELEERMGMPLFVRKTKPVRFTSAGLRLLQLADATLPLLRGAERDIARLAGGTAGRLHMAIECHSCFQWLMPTIDQFRDAWPEVELDLASGFSFAPLPALARGDLDLVVTSDPLELAGITYVPLFTYEAMLAVANQHRLAGKAYIVPEDLVTETLITYPVERDRLDIFTRFLEPADIEPAQVRTSELTVMMMQLVASGRGVCGMPHWALHEYSSRGYVKAKRLGEKGLFATLYAGIRADMLDAPYMRDFLLTAKDTSFSTLDGVSAVR
>NZ_CP014870.1|WP_064680793.1|5376284_5376782_-|GNAT-family-N-acetyltransferase
MWIERLDTRHALAYRALMLEAYDLHPQAFTSTVRERAVMPLGWWESRLTGKLDAMFGAFEEGGLAGIVGLAFEPREKARHKATLFGMYVSGSARRRGLGYKLVQAALTEAQDRQGLRLVQLTVTAGNGAAINLYKRCGFIQFGLEPMAVRVGEVYFDKLHMWREI
>NZ_CP014870.1|WP_064679501.1|5376784_5377423_-|LysE-family-translocator
MIPLQDLLIFAAAALLMVLTPGPNMIYLISRSICQGRKAGVTSLLGVVAGFFVHLFAAAAGLTAVFLAVPMAYEVLKWAGALYLMWLAWQAIKPGARSPFEAQQLPPDSSRRLITMGFLTSALNPKIAVFYLSVFPQFITPEHGSVFTQSIILGLTQISVSFCVNLLIALFAAGIASWFVNNPTWLALQRYFMGFVLSALAVRLMLEQRRVA
>NZ_CP014870.1|WP_064679502.1|5377445_5377877_-|NUDIX-domain-containing-protein
MTLASVSPRLIRIAAALLIGPDGRTLLVRKRGTEAFMQPGGKIEAHEQPVHALARELDEELGLVIDPAHATWLGQFSAPAANEPGFVVQAELFQLTIDSNVSPAAEIEEVRWIDPATDGELILAPLTRDLILPFYRASLTAIA
>NZ_CP014870.1|WP_064679503.1|5378092_5379472_-|response-regulator
MEEQLPTPQNDKPKVLLVDDEESILNSLRRLLRGQPYDVLLATSGAQALEIMAQQPIDLVMTDARMPNMDGATLLAHVHQRYPDTTRIMLTGYADPSVIIKAINEGQIHRYISKPWHDEDMLLTLRQSLAYQHSERERLRLVQQAWDQNEQLKLLNATLEKHVASRTAELQQTADMLDLAYEELKHSYVTSTEVFSLLANLRLPPPKQTNRQIIELVRVYCQRHHLDEGTGRDLTMAAALYNIGKLSWTDRMMTAPADLLHHNDRERYRGYPKQSESLLMTLEPMKDAARLILHHQERWDGNGFPDRLKGEAIPFGARLLKLAVDFIELQRGLILERQMNSDEALVYIRNYAGRLYDPGMVEDFIQVCAAYLSDVSLADPSVKVLTTRDVAAGMILARNLNADNGMLLLNAGKVLNGALVEKLIAFEAMEGAKYAIFVTVPEDLNGATLEADKVAPALH

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP014870_4	4.8|1884470|37|NZ_CP014870|CRT	1884470-1884506	37	NZ_CP014870.1	1883938-1883974	0	1.0
NZ_CP014870_4	4.3|1884137|37|NZ_CP014870|CRT	1884137-1884173	37	NZ_CP014870.1	1883938-1883974	1	0.973
NZ_CP014870_9	9.1|3078085|42|NZ_CP014870|CRISPRCasFinder	3078085-3078126	42	NZ_CP014870.1	2582700-2582741	2	0.952
NZ_CP014870_9	9.1|3078085|42|NZ_CP014870|CRISPRCasFinder	3078085-3078126	42	NZ_CP014870.1	2582842-2582883	2	0.952
NZ_CP014870_9	9.1|3078085|42|NZ_CP014870|CRISPRCasFinder	3078085-3078126	42	NZ_CP014870.1	2583055-2583096	2	0.952
NZ_CP014870_9	9.1|3078085|42|NZ_CP014870|CRISPRCasFinder	3078085-3078126	42	NZ_CP014870.1	2626389-2626430	2	0.952
NZ_CP014870_9	9.1|3078085|42|NZ_CP014870|CRISPRCasFinder	3078085-3078126	42	NZ_CP014870.1	2626673-2626714	2	0.952
NZ_CP014870_9	9.1|3078085|42|NZ_CP014870|CRISPRCasFinder	3078085-3078126	42	NZ_CP014870.1	2626815-2626856	2	0.952
NZ_CP014870_9	9.1|3078085|42|NZ_CP014870|CRISPRCasFinder	3078085-3078126	42	NZ_CP014870.1	2627241-2627282	2	0.952
NZ_CP014870_9	9.1|3078085|42|NZ_CP014870|CRISPRCasFinder	3078085-3078126	42	NZ_CP014870.1	4791715-4791756	2	0.952
NZ_CP014870_9	9.1|3078085|42|NZ_CP014870|CRISPRCasFinder	3078085-3078126	42	NZ_CP014870.1	5301096-5301137	2	0.952
NZ_CP014870_9	9.1|3078085|42|NZ_CP014870|CRISPRCasFinder	3078085-3078126	42	NZ_CP014870.1	5301238-5301279	2	0.952
NZ_CP014870_9	9.1|3078085|42|NZ_CP014870|CRISPRCasFinder	3078085-3078126	42	NZ_CP014870.1	2159922-2159963	2	0.952

1. spacer 4.8|1884470|37|NZ_CP014870|CRT matches to position: 1883938-1883974, mismatch: 0, identity: 1.0

gaaaacgccttcgcctgtaggagcgaggcttgcccgc	CRISPR spacer
gaaaacgccttcgcctgtaggagcgaggcttgcccgc	Protospacer
*************************************

2. spacer 4.3|1884137|37|NZ_CP014870|CRT matches to position: 1883938-1883974, mismatch: 1, identity: 0.973

gaagacgccttcgcctgtaggagcgaggcttgcccgc	CRISPR spacer
gaaaacgccttcgcctgtaggagcgaggcttgcccgc	Protospacer
***.*********************************

3. spacer 9.1|3078085|42|NZ_CP014870|CRISPRCasFinder matches to position: 2582700-2582741, mismatch: 2, identity: 0.952

tgtaggagcgaggcttgcccgcgaaccaggcgctgcggtata	CRISPR spacer
tgtaggagcgaggcttgcccgcgaaccaggcactgcggttta	Protospacer
*******************************.******* **

4. spacer 9.1|3078085|42|NZ_CP014870|CRISPRCasFinder matches to position: 2582842-2582883, mismatch: 2, identity: 0.952

tgtaggagcgaggcttgcccgcgaaccaggcgctgcggtata	CRISPR spacer
tgtaggagcgaggcttgcccgcgaaccaggcactgcggttta	Protospacer
*******************************.******* **

5. spacer 9.1|3078085|42|NZ_CP014870|CRISPRCasFinder matches to position: 2583055-2583096, mismatch: 2, identity: 0.952

tgtaggagcgaggcttgcccgcgaaccaggcgctgcggtata	CRISPR spacer
tgtaggagcgaggcttgcccgcgaaccaggcactgcggttta	Protospacer
*******************************.******* **

6. spacer 9.1|3078085|42|NZ_CP014870|CRISPRCasFinder matches to position: 2626389-2626430, mismatch: 2, identity: 0.952

tgtaggagcgaggcttgcccgcgaaccaggcgctgcggtata	CRISPR spacer
tgtaggagcgaggcttgcccgcgaaccaggcgccgcggtgta	Protospacer
*********************************.*****.**

7. spacer 9.1|3078085|42|NZ_CP014870|CRISPRCasFinder matches to position: 2626673-2626714, mismatch: 2, identity: 0.952

tgtaggagcgaggcttgcccgcgaaccaggcgctgcggtata	CRISPR spacer
tgtaggagcgaggcttgcccgcgaaccaggcactgcggttta	Protospacer
*******************************.******* **

8. spacer 9.1|3078085|42|NZ_CP014870|CRISPRCasFinder matches to position: 2626815-2626856, mismatch: 2, identity: 0.952

tgtaggagcgaggcttgcccgcgaaccaggcgctgcggtata	CRISPR spacer
tgtaggagcgaggcttgcccgcgaaccaggcactgcggtgta	Protospacer
*******************************.*******.**

9. spacer 9.1|3078085|42|NZ_CP014870|CRISPRCasFinder matches to position: 2627241-2627282, mismatch: 2, identity: 0.952

tgtaggagcgaggcttgcccgcgaaccaggcgctgcggtata	CRISPR spacer
tgtaggagcgaggcttgcccgcgaaccaggcactgcggttta	Protospacer
*******************************.******* **

10. spacer 9.1|3078085|42|NZ_CP014870|CRISPRCasFinder matches to position: 4791715-4791756, mismatch: 2, identity: 0.952

tgtaggagcgaggcttgcccgcgaaccaggcgctgcggtata	CRISPR spacer
tgtaggagcgaggcttgcccgcgaaccaggcgccgcggtgta	Protospacer
*********************************.*****.**

11. spacer 9.1|3078085|42|NZ_CP014870|CRISPRCasFinder matches to position: 5301096-5301137, mismatch: 2, identity: 0.952

tgtaggagcgaggcttgcccgcgaaccaggcgctgcggtata	CRISPR spacer
tgtaggagcgaggcttgcccgcgaaccaggggctgcggtgta	Protospacer
****************************** ********.**

12. spacer 9.1|3078085|42|NZ_CP014870|CRISPRCasFinder matches to position: 5301238-5301279, mismatch: 2, identity: 0.952

tgtaggagcgaggcttgcccgcgaaccaggcgctgcggtata	CRISPR spacer
tgtaggagcgaggcttgcccgcgaaccaggcgctacggtgta	Protospacer
**********************************.****.**

13. spacer 9.1|3078085|42|NZ_CP014870|CRISPRCasFinder matches to position: 2159922-2159963, mismatch: 2, identity: 0.952

tgtaggagcgaggcttgcccgcgaaccaggcgctgcggtata	CRISPR spacer
tgtaggagcgaggcttgcccgcgaaccaggcgctgtggtgta	Protospacer
***********************************.***.**

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	2473630 : 2519090	33	uncultured_Caudovirales_phage(42.86%)	plate,tail,protease	NA
DBSCAN-SWA_2	4406198 : 4412473	8	uncultured_Caudovirales_phage(83.33%)	tRNA	NA
DBSCAN-SWA_3	4746553 : 4754157	10	Enterobacteria_phage(50.0%)	NA	NA
DBSCAN-SWA_4	6282764 : 6331603	41	Bacteriophage(33.33%)	protease,transposase,holin	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP014870|2473630:2519090|DBSCAN-SWA
GTCATTTGAGTACCGCCATCAGTTCAAGCTTGAGATTGGTAAAGGCGCTGGGCGCGTAGAACGAGATGGCCTGGGCACTCATCATGCGTTCGTACACCCGGCCATGGGGCTCGATAGAGAAGTAGTGATTGTCCAGGCGCACCGGAATCGCATTGGGCAAGCGGCTCGCGTGATTGAGCGTGACCCCGGGCATGGCGCTGTTGACCACCACTTCGATGTCTTCGGGCGAACCGACCTTGAACGCGCGCGGCACCAGTTCCAGCAGGCTGGAACCCGGCATGTCGGCGTGCACGGAAATATAGAAATCGGCCTCGGCCAGGCGCGGGTCGAGCAACTGGCCCTGCCAGTACGACGGCTTGGTCTGGGTCAGGTTGATCACCACGCACTGGTTAGGCACCACGTTGTCGAGCAGGACGCGGATCATCTCGTCGAGCTTGACCAGCGAGGCCGCCGGGTCGTGATGGTCATACTCGGGGATGTCGTTGAGCTGGGTGTCCAGGGAAAACGTCAACAGGCCGCCCGCCAGCTCCGCGAGAAACAGATACAGGCGCTCGGGGTGCAGGCGCGGGTGGGCGAGCAGGTGCGCCAGGCCCGGGTGCGCACGGTTCACCGTGTTCAGCAGCCAGAACAGGGTCACGTCGCTGGAGCCGAACTCGGCAATCTGGTCCGCGCGTTCGCGACGACGGCCCGACAGCGCCTTGCTCTTGGATTGCAAGGCGCCGAGCAAGCGTTTGCCCAGCCCGATCAGGGTTTCGTGGGTGCCGACATGCAGGGTCGGGTGCACAAAGTGCGCGTCGAGGTTGAACCCCCCGATGTTGTTGCGCGACAGCCGGGCGATCGGGCACCAGCTGTAGCCATCCAGGTTGTCGCCGTCGATCAGCATCACCACGTTCAGGCGCAGGCTGGTGATTTCGTTCTCGAGGTCGCCTTCATTCAGGTCCGGCAAGGTGTCGAACTGCTTGCGAAAACGCCGTGCGCTTCTTTGCTCCTGGCCGTCTTCGATATAATTCATGCCGAAGGGCTCAGGCAGTTTCAGCGCGGCGTAGACCTTCAGGTCGTTGCCCTTGAGCAGGTCTTTCAAGTCACGGGCCGCTGGCAGCGGGTCATGCTGCGGCGCGTCATACAAGCTGCCGTCGGGAAACACCAGTTTCAGCCGTTTGAGCTGCAAGGAGCCGGTGGCGAGGGCTTCTTCATCGACCTGCAGCATCTGCACGCCCCAATGGAAGGGCGTGCTGCGCAGCGTCGATTCCGCCAGCTGATGCTGGTGGAACTCATCCTGGTATTGGAAATGTTGTGGCAAAAGGAACATGCCTTCCGACCACATCACCCGGCTTTGCTTACTCATGAACGCCTTCCAATAGAGAGTTTAATTTCGACTCCGTCGCCTTTTGCGCGGAGCTGGTGGCCGTGTCTTCGGCCTGCTGCACGACCGCGTCCTGGACACGCTGGGTGAGGCTGCCTTCAGTTGGCTGGTCGGTCTGCGCAGACGCCTTGGCAAGCTGCGCTTCGGTCTTGGGTTTGTTCAGTACGTCGACGCCGCCCATGGCGGAGACGGTGTTGTTGTCCACCAGCACCCGCAGGCCATCGGAGGAAAACCAGATGCCATCCTTGCGCAGCGAGTTGGCGTCAAAGGCGACCTTCCAGCGGCTGTTTTCTTCCGAGCGGAAAAAAGCGGCGACGCCGACATAGCCCGCGGCCTTGTTCAAAGGCCACTTGTCGACCTGTCCCATGCCCGGCAGCAGGGTGATTTCGCGGTTTTCCAGCAGCGTATTGCCCAGGGCCTTTTGCGGGTCGTCCCACAGGGTGTCGGCGTCGATCGAGGAAAAGCGCTCCAGCGAAGTCAGCTGGTACACGCGAATCACCACCGACAGCGGTTTGCCGGACTCGTCGGGATTGAGCTGATTGCCGCCGTCGGAGGTCAGGATGACCTTCTCGTTGTCGTCGAACAGCATGTCGCCGGCCCAGGTGTCGTCGACCCGCTTGCCGACTCGGTCGGTGACGCCACAGGCGGTCAGTGCCATCATCATAGCCACCGCGACCAGGCACTTTGCCAATGCTGGCTGCGCTGCACGCTTCCCTGTCTGTCTGTTATCCATCACGGTTACCTGTAAGTGCTCGATCAGCTCAGGCGACAGGCGAAATCGCCGTCGCTGTCCATCTCGATGTGCAAACTCTGAATCGGTGTGTCCTGCGCCATTCGCTCCAGCACCTGCTGGGCCAGTTCCGGCATCAGGGTCTTGGACAGAATGTTGTCGATGTTGCGCGCGCCGCTGTCGACTTCGGTGCAGCGTGCGGCAATGGCCTTGACCAGCGCGGCGTCGTAGCTCAGCACGGCTTGATGGTTGCGCTCGAAGCGCTGGCGGATGCGTTCGAGCTTGAGCGCGACGATGCGCTCCAGGATCGCGTCCTTGACCGGGTAGTAGGGGACGATGGTCAGGCGGCCGAGGAACGCCGGCTTGAACACCTGGTTCAACTCCTCGCGCAAGCCTTCGACGATTTCATCCGGCGTCGGCTGCTGCCCGGCATTCAGGCACGCCTGCATGATGTGCTCGGTGCCGGTGTTGGACGTGAGGATGATCACGGTGTTGCGGAAATTGATCTCGCGGCCTTCGCCGTCATCCAGCACGCCTTTATCGAACACCTGGAAGAACAGTTCGAGCACGTCCGGGTGGGCTTTTTCCACTTCATCCAGCAGCACCACGCTATACGGTTTGCGCCGCACGGCTTCGGTCAGCACGCCGCCTTCGCCGTAACCGACGTAACCCGGTGGCGAGCCCTTGAGGCTCGATACCGTGTGGGCTTCCTGGTACTCGGACATATTGATGGTGATCAGGTTGCGCTCGCCGCCGTACAGGGTGTCGGCCAGGGCCAGGGCGGTTTCGGTCTTGCCGACGCCGCTCGGGCCGAGCAACAGGAACACGCCGATCGGTTTGTTCGGGTCTTCCATGCGCGCGCGGGACACCTTGATGCGCTTGCCGATTTCCTGCAGCGCGTGATCCTGTCCGAGCACGCGTTCACCCAGCAGTGCGGGCAGGCGCTGGACGGTGTCGATCTCGTCGCGCAGCATCTTGCCCAGGGGGATGCCGGTCCAGCCGGAGATCACTTCGCCGATGGTGCCGCCATCCACCAGGGCGTGCACCAGCGGTTGTTCGCCCTGGACGCTGGCCAGTTCGGCGCGTACGGCGGCAATCTCGCGCACATCGGGCGCCTGGTTGTCCGGATGGCTGAGCGCGCCGAGTTTTTCCACCAGTTGCAGTTCGCGCTGCCACTGTTGCTCCAGGGTTTCGCGGGTGTGCTGCCCGGCCTGCAATTCGGTCTGCAGGGTGGCCAGGCGCCGGGCATGGTCGCTGCCTTTGGCCGCTTCCTGCTGCAGCACCGCGATTTCTGCCTGGAGGTTGTCGAGGGTTTTTTTGCAGTCTTCCAGCGGCCCCGGCTGCGCCGATTGACCCAGGGCGACCCGGGCGCAGGCGGTGTCCAGCACGCTGACGGCCTTGTCCGGCAACTGGCGCCCGGTGATGTAGCGACTGGACAGGCGCACGGCCTGCACCAGCGCTTCGTCCATCACCGTGACCTTGTGGTGATCCTGCATCTTGCCCAGCAGGCCGCGCAGCATGTGGATCGCCTTGTCTTCGTCCGGCTCCTCGACCTTGACCACCTGGAAGCGCCGGGCCAACGCGGCGTCTTTCTCGAAGTACTTCTTGTACTCGGCCCAGGTAGTCGCGGCGATGGTGCGCAGTTCGCCCCGGGCCAGGGCCGGCTTGAGCAGGTTGGCGGCATCGTTCTGCCCGGCCTGGCCACCCGAGCCGATCAAGGTGTGCGCTTCGTCGATGAACAGAATGATCGGGTGCAGGCTGCGCTTGGTTTCCTCGATGACCGACTTGAGGCGGTTTTCAAACTCGCCCTTGACCCCGGCACCGGCCTGCAGCAAGCCCAGGTCGAGGGTGTGGATGGCGACGTCTTTAAGCACCGACGGCACGTCACCCTGGATGATGCGCAGCGCCAGGCCTTCGACGACGGCAGTTTTACCCACGCCGGCTTCACCGGTCAGGATCGGATTGTTCTGGCGACGACGGGTCAGGATGTCGACCATCTGCCGCACCTCGAACTCGCGACCCAGCACCGGATCGATCCGGCCTTCGCGAGCGCTTTGCGTCAGGTTGATGGTGTACTGATCGAGGGCCGGGGTCTTGCCGTTGCCTTTTACCGTGCCGCGGGCCGTGACGTCCGCACCGGCCAATGGCTTGGCCTGTTGCGATTCGGCGCTGCCTTCGACCAGCGCGCCGAGGTTGACCCGCAGGTCGTCGGCATTGATTTTTTCCAGCTCGGGGGCGGAGGCGATCACCACCCGGCGCAGCTCGTTGTCATCCAGCAACGCCTGCAACAGATAACCGGTGCGAATCTGCCCCTGGCCGAATTCGATGGAGGCCAGCACCCAAGCCTGCTCGATCATCCGCGTGATGTGCGGCGACAGTGCCGGGGTGCGGGTATTGCCTTTCTTGAACGTGCCCAGCGCCGTCACCAATTGCGCCTGCAGGCGCTCGGGCACTACGTCGTAGTGCCGCAGGATGGCCGGCAGGTCGTTGTCGTGGCTGTCGAGCAACTGCAACAACAGGTGCTCGATCTCGACGTCGTAGTGTTGTTCCGACAGGCACAAGGCCGCGGCACTTTCGGTGGCGGTGCGGCTGGTGTCGTTCAACTTGGCAAACAGGGACTTCAGGTTCACAGGGAGACCCCATCGAATGGAATGTGGAAGAGGGCGCAACGGGACGGTTCCACGTCGACGCCCGGGCGTTTGAGCCAGCCCAGCCAGCCCAGTGACACATTGCCCTGGCGACCGAGGCGGGCCACGGGGACGGCTGCGGGCTTGAGCCTGGGCGCCAACTGGAAGTCCAGTTCGGCGCCGACGTAGAAGCGCACCAGTTCCACCAGTTTCTGGTAGTCCACGGTGCCGGGCTGGAAGCGTTGATAGTCGACCAGGTCCAGCGGGCCGATCTCGATGCGCACGCAGGATTGATAGTCCCAGACCCGGTTGCCGGCCACGGCGCTTTGCCCGAGCACGGCGTTCTTGCGACCCAACTGTGTGCACTGGCCGGCATCGAGTTTCAGCCAGCGGCCGGCAAACGGCTTGACCTTGAACGGCAGCGAAAAATAGAAGCCCAGCATCGCTTCGAGGTTCATCGCGTTGCGTGGCTTCTGGGCGAACAGGCCGGAGAAATAGCTGAACAATTCGCGCCGCAGCGGTGAGCCTTGCCTGTCGAATTTCTGCTTCTGCGCCTCGGGGCCGAAACCCACCAGGTTGAGCAGGTAGCGATCGAAATCCGAGGTGCCGTTGCGTTCGTACTCGATGTAGAACTTGTATTTCTGCCAGGCCTCGTAAAACAGCGTGGTCATGCGGTGCGAGAAAATATCGAGGAACGCATGGGCCGCGTCATCCCGGTACTGGATGTGCCGCTCGATCAACAGCTCGGTGTAGGGGCGCGGCAACACACCCGAGGGCCCGACCAGGCCCATGAACGTGACTTGCACTTCCGACAGCGGCAAACCGGCCGCGGACACCTTGCCCTCGCGCTCGAACTGCAGGTCGCTGACTTCACTGGCGGGGAAGTTGAGCGACAGCTGCGAGCGAAAACGCAAAGGGTCTTCGTGGGGTCGAGTGTCCAGGTCCATGCGCCCGGTTCTGCTGTAATGCAGGCGGAGCAAGCGCACCAATTGGAAAAATTCGAATCGGTGCGGCTCAGCCCGTGCCTGGTCGATCAGACCAGGGGTTGATCGCCGGTTCGCGGTGGCCATTGGACGACTCTCTTTTCGCGCTGCAAGGTGCGAAGGGTTAATTGGGTAAAACTGTTCATGCTGCAGTACTGGCCAAAGAAGTGGTCCAGCACCATGCCGAACAAAAACACACCGCTGCCGGTGTACTGGCTTTCATCGAAATTCAGGGTGATGCCGACGCCGCGCACGAAGTTCGGCCGCGGGTGGCCGATACGCGCCACCACCGGTTCGCTGCTCACCGAAACGATGCCGTTGATCTGCTTGCGGATCGCCGAGACGTTGCGGTAGTTGTAGAGCGACAACAGCTCCAGCAGCACGTCGCGCCCCCGGGACACCAGGGACATATGGTTGAGCGACAGGTGCGAGATCAGGCGCCAGATCACGCCATTGCCCAAGGGTACGCGGGCCGTTGCGGTGGGTTTGCGCAAGCAGCGGATGTCGTTGATCACCGAGTTGCCGGGAATATTGAAATCGCCGCGCTCGCCACCGAACGGCAGCATCAACGGCAGGTCGCGGTTGCTGCAGGTCAGGCGGATGCTCAACGTATCGTTGCTGGAATCGAGCAGCTCCAGCTCGCGATCCACCACCCGGATGACCATGTTCGAGCCATCCCGTTGTCGGGTCTGCACGGGGCGACGCCGGGCAATCCAGAAGCTTTGGCCGGGTCCCTGGTCGCCGCGCGGTTCGAAAAACGGGTGGCAGGTGTCGACCTGATCGAGGCCGCCGACCTTGCGCACCCGGCGTACGCGATCGATGGACACCACTTCGGCCGAGCTTTGCAGGCGCACATCCGGCGTCACCGCGTACTCATGCTGGGCATGGGTCAACTTGATCGGCTCGGCCTGCTGGCGGAACAGGTTGATGATCGGCGTGCAGTTGAGCTTGAAGTTATTGCGCCCGATGTTCTGCGTCAGGCGCGCCAGGCGATCGCTCAGGTCGTAATCCGAGAAATAGAAGTTGATCTCGATGTTCTCGAGGTTCTGGCCCGCCAATAGCCGCGAAAACCCCGACAGGTCGAAGAACATGAACTTGTCCGGGAAGGTGAAGTACTCGTGGAGCAAGCGATAACCCAGGAACGAGCGCTCCGAGTAATCCACCAAGCCTTCGTCCACACCATAACCGACGGCTTTCAAGGCGTTGGCCGGCAATGCGACCTCGCGAGTGCGGCCCTGGTCTTCAAAGCTCACCGTAGCCTTGGCCAGGTTGTTGAACAGCAACTCGTAGAGCTGCAGCATCAGGGTGCTTTCGCCGTCGAGGAAAAAGCGCAGGCGGTCCAGCTCCATCTTGCCGAACATCACATCGGACGTTGCCCTCAGGCCGATGCGCAGGCGCGCGACCAGGTCGGCGCTGTGACCGTTGAACGCCGAGCGCTCCATTTCGATGAACGAGGCTTGATGCACCGCCACCGGCCAGAGTTCGACCGGGTAGCAGGTGCGGAATTTGCACACCACGCCATCGATCGGGTTGGCACTGAGTTCGGTGTGGCGGGCGACATGGAAGGCTTCGGTGACTTTTTCCTGCTTGCCCAGGTTGAACTCGACAATCGACATCGACGGAGTAGGGCGCAGGTAATGCGGGTACAGCACTTCGAGAAACGACTCGACGATTTCCGGCAGTTCATCGTCGAGCTTCTTGTGCACCCGGGCCGACAGGAACGAGAAGGCCTCGATCAAGCGCTCGGTATGCGGGTCTTCGCAGTTATCGCCCTCGATGAGCAACCGCGAAGCGATCTTCGGGTACTGGCTGGCGAACTCCTGGCCCAAAAAGCGCAGGTGCGACAGTTCCTTTTCGTAGTAAGGGAGCAGATCGTCGAGCATCAGTTGAGGTTCTGCACTTTGTATTCCTGGGTATTGACCTGCAGCACCGCGTCGAAGGACACCTGACGGGTAATGTCTTGCAGACGCAGTACGGCGTCGACGCGGAAGGTCAGCATGCGTTGGCCGGTCTGTTGCGCGAGCAGCTGGACTTTGACGTTGCGAAACCGCCGGTCGCCGACGCTGATAGCTTTTTCCAGCTGGCGTTGAATCAACAGGCGGTCCTGGGGATCCAGCACGCTGCGGCTGGTGAAGTCCGGCATGCCGTAGTCGAGGATGGTTCCGCCCAGATTGGCGAAACCCTCCAGCTCGTTGGCGACCAGCGACTGGCGCGTGTTGACCAGCACCTCGAGGTCGCGAACGATGCTGGCCTTGTAATCGGCCAGCGAACACAAGCGTTGCGATGACGCTTCCATGGACTGATGGGGAAGATCGTCCAGCAAGCGATCCAGCAGCGATGGCAACAGCCTGTGTTGACTACTCATGTTGCCTCCCTGGCAGTGGTGTTGATCAGCCGCGGGTCGATTGCGGCAGTTCGGCGACCAGGCGCAACGAAGCGGTCAGTTCGTCCAGTTGATAGTGCGGTCGCAGATAGGTCACGGCCTTGTACACCCCTGGCTTGCCCGGAACTTCGAACACTTCGGCCCGCGCTTCACGCAACGGGAACTTGGCCTTGGCTTCCTGGCTGGCGGTGTCGTCCAGCAGCACGTAGCTCGACAGCCATTTGTTGAGGAACAGTTCGACGTCCTTGCGCGAGGCAAAGCTGCCGATCTTGTCGCGCATGATCGCCTTCATGTAGTGCGCGATGCGCGAGGTGGCGAAGATGTACTGCAACTGCGCGGACAACCGCGCGTTGGCATTGGCGATGTCGGTGTTGTAGTGCTTCTGCTTCTGCGTCGACTGGGTGCCGAAGAACGCGGCGTAGTCGGTGCCCTTGCAGTGCACCAGCGGAATGAAGCCCAGGTCCGACAGCTCTTTTTCCCTGCGATCGGTGATGGCGATCTCGGTCGGGCACTTGAGGGCGATTTCGCCGTCATCGGTCTTGAAGGTGTGGGTCGGCAGGCCTTCGACCAGACCGCCACCTTCGACCCCGCGAATCGCCACGCACCAGCCGTAGCGCGAGAACGCGTCAGTGACCCGGGTGCCCAGGGCATAGGCGGCGTTCATCCACAGGTACTTGTTGTGATCGCGACCATCGACGCTTTCAACGAAGTTGAACTCCTCGACCGGCGTGGTATCCGGCCCGTAAGGCAGGCGACCCAGCACGTGGGGCAGGGTCAGGCCGACATAACGCGAGTCTTCGGAGGCGCGGAACGACTTCCACTTGGCGTATTCGACGGTGTCGAAAATCTTCGCCAGGTCCCGGGGGCCGGACATGTCGGTAAACGAATCCCAGCCGAACAGCTCAGGCGAGGCCGCCGAGATGAACGGCGCGTGGGCCGCTGCGGCGACATGGGAAATCTCTTCGAGCAGGTACATGTCTTCCGGGCTGCGGTTGAACTCGTAGTCACCCAGCAACATGCCGAACGGAGCACCACCGAAGGTGCCGTATTCTTCTTCGTAGATCTTCTTGAACAGCGCGCTCTGGTCGAATTCGGACGCCGACTTGAGGTCGCGCACCAGGTCTTTCTTCGAGGCATTGAGCAACTGGATCTTCAGGGTGGTGCTGGTCTCGGTCTGGTCGACCTGATACTTCAGGCCGCGCCAGGACGCTTCCAGCTGCTGGAACTCCCGGGCATGCATGATTTCGTTCATCTGCTCGGAGAGCATCGCGTCGATTTCGGCGATGCGCGCATCGAGCACGGCAATCAGATCCTTGCTCGGCGTCATCTCGCCTTCCAGCACCTGGCTGACCAGCTCGCCGATCAGGTCGCGGGTACGGGTGCGCTCGGTCTCGGAGCGGGCCACGCGGCTCTGGGAAATGATGCTGTCGAGCAGCGAGGAGGGCGGGGCGAAGTTTTCCACTTCAACCAGATCGCTGTCCTGTTGAGTCACGGTTTGCTTGTCGTTCATCGTCAGGCTCCTACTCTTTACCATCGGTGGCTGGAACGGCGGCTTCGCGGCCGAATTCCTTGCCCAGCGTTTTCAACTTTTCAGTGTTCTGCAACACGTCCATGAGCAGCTCTTCGAGCTTGTCGTTGCCGCCCATCTTGTTGCGCAGGTCCGCCAGCTTGTTGCGCACTTCCAGCAGCTTGCGCAGCGGCTCGACCTGCTTCACCACGTTCTGCGGTTCGAAGTCTTCGAGGGTGTTGAAGTTGAGCTCCACACCCAGCTGCGTGCCATTGCTGACCAGCGTGTTGTCGACGCGATAGCTCAGGCGCGGCTTGATGCCCTTGAGCACGCCGTTGAAGTTGTCGCGGTCGATGAAGATGAACTTGCGGTCCTTGAGCTTCGGCAGCGGCTCCAGCGGGTTGCCGGAGAAATCGCCCAGCACACCGACGACAAAGGGCAGCTCTTTCTTTTCCTGAGCGTCACCGATATCCACGTCATAGGTGATATGGACCCGAGGCGCGCGAACGCGGTCGAGTTTGTGCTGGGTACTTTCCTTCTTCGCCATCGTGATCTCCTGGTGCGAACACATTCGCTGCAAGTCGTTTGCGTGTCGGCTCAACTGTTGGCCTGGCGCGTTACATTCCTTCGATCGTCAGCAGAAGGCGCTGACGGATCTCATCGTTCATTTCCACAATATTCTCGTGGCCTACCAGCTCTTCGAAGCTGGTGTTGCCGGCGATCTGGGTGCTGCTGCGGATCACCGATTCATCAGGCAATTGGGCGCGTACCGGTGAGCCGATCACGCAAAAGGGCAGGTCGCCAAAGTACTTGAGCCGCTCGAAACTCAGGGGAAAACGCAGGCCTTCAAGCACCCGGCCCACGCCCGGCGATTGGCTCAGGCAGTAGAACAACACCAGGTAGTGCACGACAAAGCGGTGCAGTTCGGCGCTGCTGCGATTGGGGTCCTTGATGACTGTGCGAAAGCGGGCCAGGTCAAACGAACTGAAACCCACCACCCAGCGCACGGGGCTGGTGATGCGAATGGATTGCCCGCTTTGGGACAGCACCTTGTCGTACTCCAGCGGGAACAATTCCGGCGTCGTACTGATCAGGGTGAGGGGGACTTCAAGCTCATTGACCAGCTGGAACGGCGAGGCCGAACCGATGCGGTCGTACAGTTCCTTGAGTTCCTTGAAATGGTGTTGGGTCTCGCGGCCGCTGCTGCGCTGCGCGCCTTGCAGGTACTCACCGAAAAACGTCTGCGGACGAATCAGCAATGCCAGGGTCGCCAGATAGTCCGAAGCCTGCGCCTTGAGCGCATCGGAAATGGCCCGGGTCTGGCTACGCAATCTGATCAGTGCTTCAACGTCAAACGTCTGAGTCATTGGTACATCGTCCTTGAATCTTCACGTCAACTCCCCCGAACAAATACGGGGAAACGGGAAGAACGAATTTCTCGGCATAACACCTGTATGCGCAGTGCGTTTTGCCGATGTTTCTCCATCGCTAATTCGCACTGCCAGGATTAATTGGAAGCAGTGTGGTGGCATATGGGTATCGAATAGCCACCAGCGTCGTATAGGGCAACGTTTTGTATGGAAAAGTTCACACAGAAGCGGATTTTTTCTCGTTTTTGATACATGTCGCAATGATGTCTGCAGGCCACTACATGCAGTAAATAGCTGTAGGAATGGTCCGAAGACCAGTGAATACAGTGGTTTCAGACGGGAAATGGATCCAATTGTTGCTTTAAAATAAATTGAAAAAGGTGAACCGGTTCACCAAACAGGCAACGAATGGAAAGGAAAAATAAAAAGAGCATGGGCAGGATCGATTTATATGTCGGAGTCATGACAAAAGCAGAGGGGGCACGAAAAGCTGGATTTGCTCCGGCGCTGAATAAAACACCGGGGTCTTTTGAGGTTACATATTGCTGCCATCGCGGTATAACGCGCCTTGTACAACGGCGCCTCAGGACCGTTTCAGGGGTGGGTTGTACAAGTGCACAAGGGCCTTCGGGCGTTTGTTAAATGGAATTTGTGCTCGCCAGGGACAGTAAGAGCGACGCAGCTATCGAGCCCATCGCGGGGAGAATGTCCTCCGGCGAATTCAAGCTGGTGGGCATCGCGTTGGTGGTGATGCTGGGATGCCTGTATTCGATCTGGCAGATGGGCAAGCAGCTGCGCGTGATGCTGCACATGTTTGAATCGACGCCAATGCCGGTTCTCGGCCAGGTCGTCACCCCCGAACAAGCGCCGGTGCTGTGGGCCTATGTTCGCGACCTGGCCGATCAACTCGGCGCCCTGGCGCCCGAACACATCGTGCTGGGCATGACCGAAGGCTTTTACGTCACCTCCAGCGACATCAACCTGCTGCCCTCGGACACCGCGCTCCAAGGTCGAACCCTGCACGTGCCGATGCTGTACCTGAGATTGCTCGACCGGGCGGAAACCAGCGCGGTGATCGGTCACGAACTGGCGCACTTCGCGGGCGCCGATACCGAGTACAGCCAGCGCTTCCTGCCGATCTACGACGGCATCGGCCGCAGCCTGGGGGTGATCGGCGAAACCATGCAGCAAAGCGACCTGCTGCAACGCTCGATCCTGCGCCCGGCCTTCATGCTCGGGATCTACTTCATGGAGCGTTTCGATCATGCGGTGAACCACTGGAGCCGCGTGCGGGAACTGGCCGCCGACGCCGCGGGCGCCCGGTTGGCGGGAAATATCGCCGCGGCGTCGGCCTTGCTGCGCATCTCCGCCATCGACCCGCTGCTGCAAGAATGTGTGGGCACCCATGTCGGCCACGCGACCAACCCCACGGAACACGCCCTGACCCGCGACCTGCCGACCAGCGTGTTGCATGAACTGGCGGCCCAGCCGCTGACCTTGCCCGAGGAAGAGCTGGCCACCCGCTTGCCGCACCCGACGGACACACACCCGTCCAACGGTGAGCGCGTGGCCTCGTTGCAGGTATCACTCGAGGAAGCCGTGAGCCGCGGCACCCGCCCCATAGTCGCAGCACAGGCCTGCGCCGCACTGGATCAGTATTTTGCCGATCCCCAGGCCTTGCGCCGCCGCGTCACCGAGGACTTCCTCAATCACTACGTGACGCAGGATGTGGCGCTGGTCGAGGAGTTGCGCACCCATGCCAGCCAGGCCACCGAGGAAGTGCGGCTGCACGAAGGTGCGCGCGTTCGCGGCTGGATCAGCCTGGTGTTCTTCGGCACGCTGATGGTGGTGGGCCTCGGTTTGCTGGTGTGGTCGCTTCTGTTCCCCGAAGCGGCAGGCAGCAAGAAGGGCGTGTTGCTGGCAGCGGGCGGCGTGCTCACCTTCATGATGGCCTGCATGCTACCGATGTCGCTGCGCCTGCTCATGCGCGCGGATAAGACCGCATTGCTGCTCACCCCCGAGCACTTCGTGTTCGCCAACCTCAAGGCGCCACTGCCCATTCAACACGTCGCGGATTTCGGCCTGCGGGTGGGGCAGGGCGTGCATTTGAATCTGTTGCTCGAAGATGACGCGCCCATGCCAGAGCTGAGCTCACGCTCGTTCTTTGCCCCTGATGTGAAGCTCGACAAGAAAAAACGCTGGGTGCAGTTGCAGCTGATGCAGTTTTGCCGGGACGACAGGAAACTCAAGGAGAAGGAGCTGGCGGAGCTGATTGGTACGTATCTGAACGCGGGGACCGCGCGGCATTTGTTGCAGCAGCGGTTTGAGCAAGTGGATTAATGGCTACCCACGCAAACGTCATAGAGCTCTGCTAGCAACGCATGCAATTCGTTGTTCTCATCCAACAAGGGTTTTGCCTGGTCGTACAGAACGATGTCGTTGATCGAGCCTGATCCACCGTACAGCAACGAACGGCGCCCTATTTTTCAAAAGCAGCAACGCTGACGGTGCCATTGTGCAAATCGACCGAGTAGCTGAGGCCATTCCAGTTACCGGCAATCACCACCCCATTTTTGTCGCAGTGGAGATTCATGTAGGGCTTGTCGACTTCCGTGCCATGGGGGCTTTCTTCGATTTGCCAGAGTAGTTCGCCGTGCATCGACAGTGCAAAGATGTTTCTGTTGAAAATCACATCGGGCGCGGGCTCGACCAGAATCAAGAGCCTGTCGTTGTGGTGAAGGGCCTCTTTGACGGGTTGAGGCAGGGAAATGGGTTGACCTGCTATCCATAGGATTCCGTCGTCAATACGGTGCCACGTTTCGGTCATCTATTTACCCCGGCGTTATCAGTGAAGTCGCAGCAATGCTATGTGCGAGGAAGACTTTCTGGTGGCAGTCCATTAGGCAGCTGAATCTTTAAGCCCTGTGCGATCTGATCGCCAATGTAGAAGGCAATTCCCAGTGCGCTAGCTAGTTCGGGATCGTTGACTTCAAACTCTTTGCCGGCCCAAGCGCCGATAGTCAATTGGTGCAGCCTCGCGTTATCTTTTTCAACGCCTAGCAATACGTTTTTTATGAATTGCAGTTGGATTAACGAGCTTGAATAAATCTGGAATTCCGGGCGCCTGTTGTATCTGAGTGCGGTGATTGCTATTGCATTGTCGATGTAATCGAGGGCAGTTATTGGCGTTTTCAGGAGGTGGTCCTCCCCGGCTACGGTGGTGTGATAGCTACGCGACGCCACATAATCATCAAACAATTGAACCTGCTCTCTGGTCAGGTCGGAGTTCCGATAATAATCAACGTGTTTTCTATAGGTAAGAAATTGTTCCGATTGTGGTCCATGAGTCAGTAGAGAAACAATGGCTGCACATTGCATTAGCCAGTAGATTTCAAACGAGGATTCAGTGCCTCGACCATAGCCAAGATTTTCACCTTGCTTGTACAACTCAGTGGCCAGTTGGCCGGGATTGTCGCAGTTTATCGTTGCCTCTGATGTCAAACCGGCCGGGTCATTCGCTATGACGAATACTCGATAGCGCTGCAATAGAAGGGCATCCACAAGCGTCAGGTCCGGGCAGGCGGGGGGTATTAGCGGTTCAAAAACCTCCGCTTCACGATTGATCGGTAGCCAAGACAAGTTCCTCTCCACTTGGGAAGGTGCCTTGGCCAACTCGGTCAAGGGGGCTTCATCAACAACCTGCCCGGTGGGGGCGGGTGGAAGACCAGTCTTTGGCCTGAAAAGAGCTTTCAAATGATGCAGTAGTTTTGACATGGGAAAGCCTTCAGCGGTCCAATCAACGTTATTTATCCATATCTGCTTCTATCTACATATCAAACAGCCGACCCTCTGTTGGTTCCAGGCTTCTCAATTAGCAACTCGTCCAGTTCTCTGCGACGGCATTTCATAACGAAATCCACTGCGGCATCAATGTTTTTTTGAAAAAGTTCGAAGCTTGCGCGATCTATTTCGTAATATTCCTCGTAGTCAACCATGCCGTTGCTAACTGGAAATGAAGCGTAGAACCTCCCGGAAGTTTTCTCGATTCCTAACGAGAAAAGTTCCTCGCGATTTACGTAAATGTCTTGAAGTTTCATAGTGTTCTCCACTTTAAAGGAGTTGTCTGAAATAGCTCCGAGGAGATCTTTCCGGCATCAATTACTGCTTCAAAGTTACCATCTGGCAATTTTCCGCCCGGAAGCCAAAACTGGTTGGCACCCGTTTCGTTGCCAGATGGGATGCGCAGACCTAGTTTGTCAGGAGTAGGAATATCAATACGCACATCCATGATTCGCAGGAGCGTTCAGCGGCCCCCATAAATAACATCGTCCATGTCGTCGTGGAGTGGGGCGCGTTCGAATAATTTTTGGGCCAAGCCTTGAATGCGTTCAGACCAGACAACCTGGCTGACCCATTCTTTCGGCATACCCGAAACCCCGTATAATGCCCCTGCTATCTGGCCGGTGGTGGCTGCCACGCTATCCGCGTCATCTGCCAGATTGGCCGCCAGCAGGATTGCATCCTTGAAGTTATCCGTGTTCCACACCGCCCATAACGCCGCTTCCAGCGTATCGATGACGTAACCTGAGGATCGGATTTGATCGCGGGTTTTTTGTTTGTACTCGCCAGCATTGATGATCAAGGGGCGGGGATACAAGGCCCGAACCATTGACGACAAGGTTTCTTCTTTGTCTGCGCCATTGAGCGCCAAATGTAGTTGGGCACCGAGCAGTTCACAGCAATTTACGGCTTCAGCAGCCTTGTGGGTGACGCGGCTTTGTGCCGCGCTTTCCCGCAAGGTTGCGGATAATGAATGACGACGATAAATAGCAGTCGGTGCCAGTCGGATAATCGTCCCATTGCCGGCAGTGGAAGGATCATCGTTGCCGTACCAATCGCGCCCCTGCGTCAGTCGTCCCTCAAGCGCGGTACGAGTCGCATTGCCAATGTCGAAACATTTACCGTTATGGCTGTTTTCTCCGTTTTTGTACCAGCGACAGAGTCTCTCGGCATAATCGTAAAAGTCGAAATCGCTCCTTTCGAGATAGGTATCTGCCAGACAAAGCGCCATGCTTGTATCGTCGGTCCACTCCCCGGGATTCAGTTTGAATGGGCCGCCGCCTACCATGTCCATGACGGCTTCACGATCGCGGGGCAAGAACTCCAGTGTTGTACCCACCGCATCGCCGATTGCGAGCCCGAGCAGGCATCCTTTTGAACGGTCCAGCGCTTGCTCTTCAGTAATTGAGCAAGGTCTCGAAGTCAGCCAGTCAGGCTTATTGTTCGGTAATCTGGGTGCGTCGGGCTGCAACGTATAATCCATGCGCTGGCGCAATTGCAGAGAGGGGGGCGGAAGGAGGTGGTCATAGCGCTCGATATATTTGGCGAGCACTTCGTTCGAACTTCTTAAATCAATCATGGGATCTCTTGGTAAAGAAGGTGGGTCACTGACCCGGATTCAATTTTATTAAGCACATTGAATTGTGTTCCCGGAGGGTAGAGAACCTCCGCCTCGCGGTGCCCGGATAGAAAGCTGATGTCCCTTCCAGATGTGCCACGAGTCACGATTCGAACGTTGCCACTGAAAGCCTTGCCTGTCTCAGCAGAGGTGCTAAAGAATGCGCCATCGCTAGTAGGATGTCCCATTCGTATTTCGGTGAGTACATCTGCTGGCAAGCTTGTTCCCCGGTAGGTTTCACCTTCTACATAGCGAGGAAGCTTGGCTAAGCCATCTTTTGCATGCGTTGCGAAGGCCTCCATTTGCTCAGTAATTGGCGTCTTTCCGCGTAAGGCCGGATTGATCCAAGTGTACCCCTCATTCGTTGTGTACCCGTGAAGAGCCCCAATCTGGTCATCGGTTAGCAACCGTGAACGATCAGGGTCAGCTTTGTCGGCAATTTTTCTACCGTTTGCAATCCATCTTTCTGCAGTTTGCTGGCCCACCGCATCTCTGAGCGACATCAGCGGTGGCGGCGCCGGTGGACGCTTTGCCTCAACGGGTCGCTCCGTTATTTTTTTGACTTCAGGTAATTCCACCTTCGCCAAAGGCGCCGGTTCCTTCACATGTAACTCAGCCTGAGCCAACAACTTCTGCTCATTACGCGCCAACCAGCCCGCCAACTGCTTGTTCGATATCTGGGCCTGTAGCTTCGCACTGCGTGTTGCGATGCTTTCCATGCTGCCCACTACGCCCGCCTTCATCTGGCCGCGCGTCAGGTAGGTGACGATGGCAGTGAGTAGCAGCAACACCAGTTGCTCCTGGCCGCGAGCCAATTGGCGCGCCGAGCGTTCGATGCGTTCCTGCACCAGCGCCGCGGAGCCGCCGGTTGGGTCCAGGCCGGAAGGTTTGACGCCTTCTTCGGCGTGCCAGGCGGTGGCAATGCCTTCCTGCAATGAAGAGAGGCAGGCGGGCAGGCCTTGGTAAAAATACTCGGCGATGGCGGATAAGCCCAAGCCCATCAGAATAAGATTGCCGACTTGCAAGCCGATACCTGCCCCGGCGGCAGCGCCGGGCGCTGCGCCAATACCAAATGCAAATGCACCCGCTGCGCCGCCAGCCACGGTGCCGATCGCGACGCTACCGCCCAGAATCATCGAGACTTCTTTGACCAGCTGCAGCAGCACAGGAAGGATCTGCTCGATTTCGATCGAGGCCCACTTGCGCTTGAGGTCCATCTGGATGATCGGGTAGGAGAGGGTCATCGCCCGATTCACTGCATCGATCCGGTGACCGCCCATGTAGCCATAGGCCTGGCTAGCACCGTTACCTACTCGTCGGGTGAAGCCGTTCCAGTTGTCGTGAACGCTCTGCAAGCCTTCGTTGACGCCCTGGTTCAGTTCGCTGAATTTCTGATCGAGGTTTCGTTCGACGTCGGCCCAGCTGGGCACATTCGCTAAAAGATCCATTTACACATCACTGTCCTTGGGTGGAAGAAGCTTCCCTGTCGCCACGTTTGAAGTGTCGGATATCCGACTTTATGCCCAGGATAAAGTACTGGCCATTAGCCGCACTCTAGACTGCATCAGGCGCAATAAAATTCAATGTGGATCCCATTTTTTATTGTTCAGGTAGGCTAGGCAATGATGTCAATGAGGCACTAGTTGCTTTTTAATGGCGCGTAATGCCCCATTCCTCCTTGATATACCGGCGTTTGTGGCGCGCCAGAGCGGCCGATAATTATTTTTCAGACTTCAGCGGGGCATGAATCCCTATCTGAGTAGCAACCGGGAAATGCCGTTTCCGGGTTGACACAGTGGATGGCGAAGGTGTTTCCTTTGCCGCTTTCGGAGGACTGTAACGCCTTTGATAACGTGACGTCCCTCGCATTTTTGCTTGAGTGATGGCACTTTCGCATTGGTCTGCGGTCGCATTATCAGTCTTCGAATTCCGTTTGCGAAATGTCATTGATTTCGAAAGCTGACGGCACAAGTTTGTAGGCGGATTCATACAAAGTCCGAGCTGTTTCGCTCCGCCAGTTTACGGAGCAGCGGATTGTTTCCCCAATCCACGATGTTGTAATCGGGTTTCGACCCTTCTGTCAGATTCGTTATGCGCAGTGGTAGGCGAGGGCGGTAGCGTTCCCCACTGCTTTCAAGGAGATACACATGTTGATGGACCTAGCCGCAATGCTTTCCCCGCAGAATCGGCGTCTGTTCAAGTTCACGAACCTTGCCAATCCCGACCAGCAGCTATTGCTTGAGTCCTTCAAGGGAACTGATGGTCTGTCACGTGCCTATAACTTCGAATTGATGCTGGTGTGCCAGGATTCGGGGGTGGAGCTCAAGTCAATGATGGGCCAGCACGTGGTGCTGGAGATCGAGTTGGCCGAGGCGGGCCCGCGGTACATGGCGGGTTATCTGACCCGCTTCGCCAGTATCGGCAGCGACGGCGGCATGGCCCGCTACACCGCGACGCTGAATCCCTGGTTCTCGATGCTGAAAAACCGTTTCGACACGCGCATCTTCCAGGGCTGCACTGTGGAAGAAGTGGTGACTCAGGTGTTCGCCTTATGCTCCGCGTTTTCCCGTCACGAATTCCGCCTGAGCAAGCCGCTCAAACGCTACACGTACATCACCCAATACCGCGAAACCGACTTCAACTTCGTCCAGCGCCTGCTGGAGGAAGAGGGGATGTTCTATTACTTCGAACACACCGCCGACACCCACACCATGATCATCTGCGACGACTCCAGCACGCTGCTGCCGTTGCCTGAGCAACCACAGATCCGCTTCCATACCGCCTCGGTCACCGAGACTGCCGACTCCATCACCCAATGGAGCGGCAACCGCCAGCTGCAGTCCGGAAAAATCGCGGTCCAGACCTTCGATTATCGCCAGCCGACCAACCGCCTGCCGGTGGCCATGAAGAGCCTGAACAAGCAGGGCGATGTCGACGATTTCGAGATCTACGACTTCCCCGGCCAATACACCCATGGCACCTACGACGAAGGTGAAGCGCTGGTCAGGCTGCGCGTGGAAGCCCTGGAGCTGAAAGGCAAAAGCTTTCATGGCGCCAGTAACTGCCGCGCGATGAAACCCGGGTACACCTTCGAACTGCTGCAGCATTACGACCACGATCAGGGCTCGGCCGACGATCGCCAGTTCCTGTTGATGAGCGTCGAAAGCGAAGGCCACAACAACTACCTCAATGGTCATCAGGCGAGCTACTACAACACCTTCTCCTGCGTGCGCAAAAAGATCGTCTTCCGCCCGCAACTCACCACCCCGCGCCCAACCATCTCCGGCCCGCAAACCGCCATCGTCGTCGGCCCGCCGGGCGAGGAAATATTCACCGATGAACTCGGTCGCGTGAAGGTGCAGTTCCACTGGGACCGCAAGGGCGAGCACAACGACAAGAGTTCGTGCTGGGTGCGCGTTGCCCAATCCGGCGCCAGCGGCGGGTTTGGCAGCATCCTGATTCCGCGGGTTGGCGATGAAGTGGTGGTGGTGTTCCTCGACGGCAATCCTGATCGGCCGTTGATCATGGGCAGTTTGTACAACAGCAAGAACACTCCGCCCTGGTCGTTGCCGGCGAACAAGACGCAAAGTGGGTTTTTGACCCGGTCGATGAAAGGCGACGGCGGCACAGCGAACTTCTTCCGCTTTGAAGACAAGGCCGGCGCCGAGCAAGTGATCATGCACGCCGAACGCAACATGGACACCGAGATCGAGGTCGACGAGACCCACAGTGTCGGCAGCAATCGCACGATCACGGTGGGTGGCACGCACACCGAAACGATCAAGAAAGACACGGTGATGAATGTCCAGGAAGGCTCGCTGACGATTCAGGTCGATAACCAGTTCATTCAGGTGAATGCCAAAGAGCACATTATTTTGCAGGTGGGAGATAGCAGTATCACGCTGACTCCTGCCGGGATCGAGATTAAAGGTGACGTCATCAATATTCTTGGCAAAAACACCTATGTTCAAGGTGACCGTGTCGATATCAACAAGTGAGAACGCAGACCATGGTCAGGACCAGTATTTACGACCGAATCTCTGAGAAGCGCCTGGCGGCCGAGGCGCTTGCGCGGCAGCTACAGCAGCAAGCAGCCGACGCGCCACCGGCTGTTATCGAGCCCGAGCCCATTGTCAAAGTGCCGCTGCAGCTCGCCCGTAATGGATTGACAGTCGCGGGCCTCAATTTGCTGATCCCGGATGGATTCAACTTCCGCGACATTGACACCACGCTGGAAAAGTATGGACATCCCGTCACGTTTGGTGCGAAGCGCCGTCCTGCGCCCGAAGGTCTGACGTTGAGGCGCGCCGTCGAGCTGTATGTGGAAAAATTGCGTCAAGACCACCCCGACGTCACCATTGTGCGGCAGAGCGATGGTGTGCTCGCGGGCCACCGGGCGATTGCACTGGATTACATATTCACTGCCGGTCAGGAACGCCGCCATGGCAGAGCAATGAGTGCTGTGATCGAATCTGATAACGGTAACGAGCGTCAGTGTTTCAGCATCTCCACCATGATAAATCCGGCACACGCAGAGCTTGCCGATTGGCTGATCGAGTTCGACGCCATGCTGGAAAGTGTCTCTGCTGACTGAACATTTCCCTTTTACGCATTCACGGAATACACCTCCAATGGACTATCAGCTTCAGGAAGGATCTATCGTACTGCCGGAAGGTTTTCAGGACCGTACGGTAAATATGTTTGTACTCGGTAACAGCATCCCGGCTCCGCTCAACATTACGATATCGCGTGACAATATGCTGCCCGCCGAGTACCTGAAAACTTACATCGAGCGTCAGGTGAAGCTTATAGCTGCCAAGCTGCGCGGCTACACATTGCTCAGCAAGAAACCTGCGACGTTATCGAGCGAGCAACCGCGCTCAGGCATCCAAGTGGATGCTTACTACATGAACGATGGTCGTCCTGTTTATCAGCGTCAGGCGGCTTTTGAGATCGAGCAAGGTCGTATTCTAGTGTTCTCAACGACCAGTCAAGCTGATTTTAGCGCCACTCAAAATGAGAACTGGCTGCAACTGCTGACCAGCTTCCAACCGCGCCAGGACACCGTGCCCACTGACGTCGAACAGGAGTAACTCATGTTCGAAGCAGCTCGTTGGGGTGATGAAATTGAGCACACCAGTGCTCTTGGCGGGTTCCTCGTTGGTGCAGTGATTGGGCTTGCGATAGCAACTGCTGCCGCATTCACGATTTGTACGGCTGGTTTGGGTGGAATCCTGCTGAGTATTGCAGCAGGCGTGGGTGCCAGCTTCATTCCGGCGATTGGGGAGAGCATGGGAGCGGCACGAAGTTCTCCAGCCGGAGGAATAAAGCTGGAAGGGTGCTCTGCGGATGTGTTCATCAACAACCGTAATGCTGCCCATGCAACTCTGAGTCAAGGCGCGTGTGATAAACACCCGGCGCCGGTGCTAGTTGCGGAAGGTTCGTCCAACGTATTCATCAACAACGTGGCGGCTGCGCGCAAGGGTGACAAACTTACCTGTGGTGCGAAAATATCCAGTGGCTCGAATAACGTGTTCATTGGTGGCGGAACAGAACGCTATCTCGACGTAGACGAAGAGGTACCGGCCTGGCTACGCGTTACCGTCGATGTGTTGATGATCGTCGCTTCCATGGGGCGCGCGGTAGGTCCGATCTTCCGGCTCGGACTGACACAGGGGCTGAAAGCTGCCGGTCCGTGCGCATTGAAGTTTGGGGCAACAATCGCAGGTAGCTATCTGGCCGGTCGTTTCATAATCGGACCGGCCGTAGAGCGCGCGATCGGCGGCTTAAGCGGCAATCCGGTTGATCTTACAACGGGGCGCAAAGTGTTGTTCGAGTCGGGTGAAACCGACTTTGCGCTCCCTGGGCTAATGCCCATTGAATGGTCTCGTTTCTACGCAAGTGATTTGAACGTTGAAAGCGTGCTGGGTAGAGGGTGGGTGCTGCCGTGGGAACAAAGTCTGCGCAGAAGTGGCAGCTTCGTCTACCTCACTGATAACCAGGGGCGCAGTGTGCCTTTTGTTGACGTTGAACCTGGCGATCGCACCTACAACCCTTATGAGCAAATCCACTTGGTTCGCACTGAGGGCGGTCACTACCTCCTACAGACACTCGACAACACTTTCTTCTATTTCGGCGAAGTGCCGGACGACGATACTGCTGTTCAGTTGCAGCGCATTGAAAATGCCCTGGGGCATTACCTGCACTTCAGCTATTCGGCCGACAATACGCTTACCGACATCAGCGCCCCGGGCGGTGTCCGTGTTCACCTGCATTACGACAATCCTCTGGGTCGCCTGACCGACGTCAAGCGTGTGGTCGACAACCTCGCCGTCGAAACCCTGGTGCAGTACCGTTACGACGAAAATGGTCAACTGATCGAAGTGATCAATCGCAACAACGATTCCGTTCGACGTTTCAGCTACGCCGATGGCGTCATGGCCAGTCACAGTAACGCCCTCGGCCTGACCTGCAATTACCGCTGGCAGACCCTCGGCGATCAGCCTCGCGTGGTGGAGCACTGGACCAGCGATGGCGAACATTTTCACTACCGCTACGACTTCAACCAGCGCGTTTCCTGGGCTACTGACGTGCTGGGGCGTGAGTTGGAAATTCAGTACAACGAGGACCGTCGCGTGATTGCCAGTCGTGATTACGGCGGCGAATGCTACGGTATTGCCCTGGACGAAGCCGGCAACATGACGGGTTTGAATCTGCCCGATGGCAACAAGCTCGCGTTCAAATACGACGACTTTTCACGCCTGATGGAAGAGACCGATCCACTGGGTCGCAAAATCAAATACAAATATCACCTCAGTACCACGCTGGTCACTGAGACGACTTTCATGGACGGCAGCACCTGGAAAGCCCGCTACGACGCCAAGGGCAACCTCATCGCCGAAGTCGACGCGCTGGGCCACAAAACCGAATACCTGAACAGCGACGACGGCTTGCCGCACACCATCATCGACGCCACGCACAAGTCCAAATACCTGTGGTGGAACACCCTGGCCCAGGTCGAGCGCTTCCAGGACTGCTCGGGCAAAAGCACCCACTACCGCTTCGACGAGCGCCACCACCTGATCGCCGTCACCGACGCCCTGAACCAGACCACCACCCTGGAACGCAAACCCGACGGCGAAGTGCTGCGCATCCAGCACCCGGACGGCAGCGCCGAATCCTTCACCTACAACGCCCTCGGCCAGGTCCTGACCCACACCGACGGCAAAGGCCAGACCACGCGCCTGCTGCGCACCGCCCGCGGCCTGCCGAGCAGCCGCCAGGACGCCAAGGGCCAGCGCATCCGCTATGAATACGACCAGGCCATCCGCCTGACCGCGCTGGTCAACGAAAACAATGCGGCCTACCAGTTCGCCTACGACGCGTCCGACCGGTTGGTTGAAGAGAAGCGCATCGACAACCTGACCCGCCAGTTCAGCTACAACCTCGGCGGGCACCTGACACGGGTGGATGAAATCGGCTACGGCGAGCGCGGCGAACGACCACAACGGCATACCGAATTCGAGCGTGACCCAATCGGCCGACTACTGGCCAAACTCAATGCCGATGCGCGGCAGGACTACACCTACGACGACGCAGACCGTTTGCTCACCATCGAGCGCCTGCCCACCGCCAACGGCAAAAAACTCGGCGTCAGCGCAGAGAAGCTCGATTTCTCCTATGACCTGCTGGGCCGTCTCATCAAGGAGACCACACCCCAAGGCGAGCTGGCCTACGACTACGACCCACTAAGCAACCTGACCACGCTGACTCTGCCTACCGGCCAGCACCTGAACCACCTGTACTACGGCAGCGGCCACCTGCACCAGCTCAACCTCGACGGCCAGTTGATCAGCGACATGGAGCGCGACGACCTGCACCGCGAAGTGCTGCGCACTCAAGGCACGCTCACCAGTTGTTTTGGCTATGACGCGATGGGCCGCAAGGCTTGGCAATTCGCCTCGACTTTGCCGGCAGAAAAACTCTCGCAGATTCTTAACCCGGGCATCCAGCCTGAACTATTGGTAGAACACGCCTATAACCCGATCCACCGCCGTCACCAATACGATCCCGCCGGCGAACTGACCCGCACCCTCGACAAGCTGCGGGGTGAGATCAAGTACGACTATGAAGCCAATGGTCAACTGCGCAGCCGTGACACCGGCAAGCTGGTGGACAGCGAAGAGTTCAGGTACGACGCAGCGGCGAACCGGCTGAACTTCAACACCAGTCAGTTTGATCACGTGAAGAACAACCGGATCAAGCAGTGGCGCGATCAGGAATATGCCTACGATGCGTGGGGTAACCTGATTGAAAAGCGCAGCGGGTTGAGCCGGCTGCAAACGTTCAGTTATGACGGCGAAAATCGGCTGGTCAAGGCCGAGACCTTGGTGAATGGCAAGCTGGAAAGCAGCGGTGCCTATCGTTATGACAGCTTGGGACGGCGGGTGGCCAAGGTGTCAGCGGTCAACGGCGTCACCGAGCAGAAGCACTTTTTGTGGCAAGGCCTGCGCCTTTTGCGCGAGGAAACCCCGGGGCAGAGCAGTCTGTACCTCTACGAGCCGGGCAGTTATGCGCCGTTGGCGCGGGTGGATCAGGTTGAGGGTGGGGAACAACAGCTCTATTACTTCCATACCGACCAGATTGGTACGCCGCTGGAGATGACGGACCGAGAGGGGCGGATTGTCTGGCAGGCGACGTACAAGGCGTGGGGCTCGGTTGAAAAGCTCGAAGTGAACGAGGTCGAGCAGAACCTGCGGTTTCAGGGGCAATATTTCGACGACGAGACGGGGCTGCACTACAATACGTTTCGGTATTATGATCCGGAGGTTGGGCGATTTATTACGCAGGATCCTATCGGGTTATTGGGCGGAGGCAATCTTTATTTTTACGTTCCCAACTCGATGGGCTGGATTGACCCTCAGGGATTGTCGAGTGCCGACTTACGTGTTGAATTGGGTATGCGGCCTGGAGATATGCACGCAGCTCATCACATTATTCCCGAAGAAGTGATGAAGAAGTATCCACAAATGTTCGACAAAGCGAAAACGTTCGGATTTATGCCTGATGGAGCGTCCAACGGTATCGAGTTACCTCGAACTAAAGACTTGGCTAAAACCCTTGATCTCCCTGGCCATTGGAGCAATCACGTAGACTATACTGCTCTAGTTGAAAGCGATGTGAGTAAGCTCAATACCGCCTTCAGGGCAGGGCGATTAACCGATATGGACCTAGCGTTAGGGTTGAAATCTATTCAGAATAAATGGCGATCAAATATTTTAGCTAAAAACGTACCAACTAACGCTAAAGGTCGGCTTTGTTAAATTTGAGGAGGGTGTGATGTACATAATCGGTTATAAGGGTGGTGAAGATGGCTGTCCCGAAAATAGTATCTACGGGGAATTGGTTGGGTATAATTGGAATTCCAATGATTTTGCAGACAAAAAATTTCCGTCAGTCGGAACAATTTTAGATTTTTATGCGCAGCATCGAATCGTAGATTCGGATTTTTTTTATTTTGGTAGCGAGTTTATTTGCTCCGAATTTTTGCTGCGTTTGATAATTGATAGTAGTTTCGGGAGTGTAGATATTAGAGATGTTCGGCTGCATCAACAAAACAAAGCATTTCCGCTAGCTTCAAAAAAATACTATCTGTTGCGGAGCCGAGAGGTCCACAAAATTTTAGATATGGCGAAATCTACATATGAATTTCGATTCGATCCAGTTACCAAGACTCCGGAAGAAGATGCTTATCACTCGGGTAGGTTGATATTCGACTTGATATCAGATTTCCAACTTAGTGAAAATTTATGTCCGCTAGATATCTTTGTTGCATCGGAGATGCTGAAGGATGAGTACGTGATTTCAGATGCACTTGCAGAAAGGATCACTGAATGTCGACTCAAAGGTGTTAATTTAACGCCGCTATCAAAGTATATATATGACGCTAAGCTGGAATTCTGATCCAAGTCAGCTTGTCGGTAGGGGGCAAGTTAGGGCGCCATATGCATCTATTTAAATATTGCTCGATCGAAGCGGATTGCTTCAGAAAAATTAATCTTAGTACTGCTTCAACGATATCCATCCCAAACTCAACTCCGGCGCCCGCCAAGACTACACCTACGACGACGCAGGCCGCTTGCTCACCATCGAGCGTCTGCCCACCGCCAACGGCAAAAAACTCGGCGTCAGCGCGGAGAAACTCGATTTCACCTAGGACCTTCTGGGCCGCCTGATCAAGGAGACCACGCCCCAAGGCGCGCTAGCCTACGACTACGACCCACTGAGCAACCTGACAACACCGACACTGCCTACCGGCCAGCACCTGAACCACCTGTACTACGGCAGCGGCCACCTGCACCAGCTCAACCTCGACGGCCAGTTGATCAGCGACATGGAACGCGACGACCTGCACCGCGAAGTGCTGCGCACTCAAGGCACGCTCACCAGTTGTTTTGGCTATGACGCGATGGGCCGCAAGGCCTGGCAATTCGCCTCGACTTTGCCGGCAGAAAAACTCTCGCAGATTCTTAACCCGGGCATCCAGCCTGAACTATTGGTAGAACACGCCTATAACCCGATCCACCGCCGTCACCAATACGATCCCGCCGGCGAACTGACCCGCACCCTCGACAAGCTGCGCGGCGAGATCAAGTACGACTATGAAGCCAATGGTCAACTGCGCAGCCGCGACACCGGGAAGTTGGTGGACAGCGAAGAGTTTCGCTATGACGCGGCGGCGAACCGGCTGAACTTCAACACCAGTCAGTTTGATCACGTGAAGAACAACCGGATCAAGCAGTGGCGGGATCAGGAATATACCTACGATGCCTGGGGCAACCTGATTGAAAAGCGTAGTGGGGTGAGCCGGCTGCAGACGTTCAGTTACGACTGTGAGAATCGGTTGGTTAAAGCTGAGACGTTGGTGGGCGGCAAGCTGGAAAGTACCGGGGCTTATCGTTATGACAGCTTGGGGCGTCGTGTCGCCAAGGTGTCGGAGGTCAACGGCGTAACGGAGCAGAAGCATTTTCTGTGGCAGGGCTTGCGCATGCTGCGTGAGGAAACGCCGGGGCAGAGTAGCCTCTACGTTTACGAGCCAGGAAGTTACGCGCCGTTGGCGCGGGTGGATCAGGAAGAGGGCGGGGAGCAGACGCTTTACTACTTCCATACCGACCAGATTGGTACGCCGCTAGAAATGACGGACCGCGAGGGGCAGATTGTCTGGCAGGCGACGTACAAGGCGTGGGGGGCGGTGGAGCGTCTGGACGTCAATGTAGTCGAGCAGAATCTGCGGTTCCAGGGGCAGTATTTCGATGATGAGACGGGGCTGCACTACAACACGTTTCGGTATTATGATCCGGAGGTGGGGCGGTTTATTACGCAGGATCCGATTGGCTTGAATGGTGGAGACAATCTCTACCGGTACGTACCTAATCCTACCGGTTGGATTGACCCATGGGGATGGGAGTGCTGGAGCACCGCGAGAAGAAAATATTGGAAAGCTGAAGCGCAGGCACCGAGCCAAGTATACTCACCTGCAAATTTAGCCAATATGGCGGAAGGTAAAGCTCCTAGAATGACAGTAGAGGTTGTAAATCGCAAAACGTTAGAATTGTCACGAAAAGACATCGCGTTGGAGTTGCATCATAATGACATACCGCAGCGCATAGGAGGTTCTGGTGTGCATGAGACTTCTAACTTGCTATCGTTAACGCCGTGGGAGCATGAGGCTGTCGATTCATTTAGGCACGTAGGCTCAGACTTAATCAGAGTAGTGAAAGGGGTAGACGTTTGGTGACTGTAAATTCAGAAACTGCAAAAGAAATAATCAATTCAGAAGCTTATAGGACGTTGGTCGCTGAGTTGAAAAGCCACTTGAGGATTTCTGTAATAGAAAGCTATGAGGATGTGTTTGCAAGATTAGATGCAGCTTCGATAATAAGATCTGAATTGGAAGTGGATGAAATAAAATCTCTATTTGGTTTGCGTTCTAATGAGCTAAAAAGATACTCGATCAAAAAATATACAGCACTACACGGTAATCCTGATGAACAAGAGTATCCAGTTGGTGAAGAGCCAAGCACTGAGGATAAAGATTCAAATATAGTTAGCCAAGGCTATGCTCCTGGTTTTTTGCTAATAAATGCTATAGAGTTATTACTTTCCTGCAAAGGCGTAGATTCCCTGAATAAATATTTGAAAGCGTCCAGGATTCCCAAGGCCCATTCGTATTCAAAGCAAGTAATTAAATTTAGTAATATGAATTAGTCGATCAGAATTGATCTAAATCGTAGTGAGTGTTTTTGCGCGAGCGTGTGTTCTTTAGGTATGATAGCGTTTGGAAGTTCTTTAAAAGCCTACTTGTAGTAGTGGCTGGTGTTTCGGTCATATTCCGTAAGTAAAGTTTATGGGTGCACTAGCTCGGCTGATTGTTTTCGCCTTCATATCCAAATACCTGTGGTGGAACTCCCCGGCCCAGGTCGAACGCTTTTAGGACTGCTCGGGCAAAAGCACCCATTACCGCTTCGACGAGCGCCACCACCTTATCGCCGTCACCGACGCCCTGAACCAGACCACCACCCTGGAACGCAAACCCGCCGGCGAAGTGCTGCGCATCCAGCACCCGGACGGCAGCGCCGAGCCCTTCACCTACAACGCCCTCGGTCAGGTGCTGACGCACACCGACGGCAAAGGCCAGACCACACGCCTGCTGCGCACCGCCCGCGGTCTGCCGAGCAGCCGCCAGGACGCCAAGGGCCAGCGCATCCGCTATGAATACGATCAGGCCATTCGCCTGACCGCGCTGGTCAACGAAAACAATGCGGCTTACCAGTTTGCCTATGATGCGTCCGACCGCCTGGTCGAAGAAAAACGCATCGACAACCTGACCCGCCAGTTCAGCTACAACCTGGGCGGACACCTGACACGGGTCAACGAAATCGGCTACGGCGAGCGCGGCGAACGGCCACAGCGTCATACCGAATTTGAGCGCGATGCGATTGGCCGCCTGCTGGCCAAACTCAACGCCGATGCGCGTCAGGGCTACACCTACGACGACGCAGACCGCTTGCTGACCATCGAGCGTCTGCCCACCGCCAACGGCAAGAAACTCGGCGTCAGCGAAGAGAAACTCGATTTTGCCTACGACCTGCTCGGGCGCCTGATCAAGGAGACCACACCCCAAGGTGCTCTGGCCTACGACTACGATCCGCTGAGCAACCTGACCACGCTGACCCTGCCTACTGGTCAGCACCTGAACCACCTGTACTACGGCAGCGGCCACCTGCACCAACTCAACCTCGACGGCCAGCTGATCAGCGATATGGAGCGCGATGACCTGCACCGCGAAGTCCTGCGCACCCAGGGGCACCTCACCAGCTGCTACGGCTACGACGCCATGGGCCGCAAGGCCTGGCAGTTCGCCTCGACCCTGCCGGCGGAAAAGCTCTCGCAACTCCACAACCCCGGCATCCAGCCGCAACTGCTGGTAGAGCACGCCTACAACCCGATCCACCGCCGTCACCAGTACGACCCGGCCGGCGAACTGACCCGCACCCTCGACAAGCTGCGCGGCGAGATCAAGTACGCGTATGAAGCCAACGGCCAACTGCACAGCCGCGACACCGGCAAGTTGGTGGACAGCGAAGAGTTTCGCTATGACGCGGCGGCGAACCGGCTGAACTTCAACACCAGTCAGTTTGATCACGTGAAGGACAACCGGATCAAGCAGTGGCGAGATCAGGAATATACCTACGATGCGTGGGGTAACCTGGTTGAAAAACGCAGCGGGTTGAGCCGGCTGCAGACGTTCAGCTATGACGGCGAAAATCGGCTGGTCAAGGCCGAGACCTTGGTGAATGGCAAGCTGGAAAGCAGCGGTGCCTATCGTTATGACAGCCTGGGACGGCGCGTGGCCAAGGTGTCAGTGGTCAACGGGGTCACGGAACAGAAGCATTTCCTGTGGCAAGGCTTGCGGATGTTGCGCGAGGAGACGCCGGGGCAGAGCAGCCTGTACCTCTACGAGCCGGGCAGTTATGCGCCCTTGGCGCGGGTGGACCAGACGGAAGGTGGGGAGCAGAAGCTCTATTACTTCCATACCGACCAGATCGGTACGCCGCTGGAGATGACGGACCGCGAGGGGCGGATTGTCTGGCAGGCGACATACAAGGCGTGGGGAGCGCTGGAGCGGTTGGAGGTCGATGACGTCGAACAGAACCTGCGGTTTCAAGGGCAGTATTTCGACGACGAGACGGGGCTGCACTACAATACGTTTCGGTATTACGATCCGGGGGTGGGGCGGTTTATTACGCAGGATCCGATAGCGCTTTCTGGAGGGATGAATTTCTACTCGTACGCACCGAGCCCTAACAATTGGGTCGATCCGTTAGGCTGGTGCTCTACGAAGTTAGGTAACAACATGGGGGCGCGTCCCGGCGATGGAATGGCGAACCACCATTTAGTACCTGAAGAATTGATAAAAAGTGCTCAATTCAAAAGTATGTTTGGTAGGCTGAAAAAGATTGGATGGGATCCCGATGGGGCTTCAAATGGCATTTTCCTCCCGGGCTCCAAAGACTTGGCTAAATCTACCGGTATGCCCGGACACTGGTCAAGCCACGGTCAGTACACTGAAGCTGTAAAAAACAAACTTGTTAAACTAAATAATAATTTAGGTAGTTTGACAGATATGGACCTTGCGCTCGGCGTCAAAAATATTCAAGCCTGGGCCGGTGAGGAGCTTGAGGGCGGGTTGTTCAAGCTTGACGCGATAACTGGTCGACTATTGTGAGGCGAAAAAATGAAAAATTTATACATTGTTAGTTATGAGCCTGATGGTGAAGGGGCACCATATTTTTTTGATTTTAAATGGATTCCGGAGTTGCCAGAATTCCATTATCCTACCGAAAACCCTGAGTCGGGTGAATTAATTGCTAAGTATCGAGCTGTGGCCGACGTGCCGCAGCTAAATGCAGACTGGTTGCCCGATCACTTTTTAGCAAGCGAAAAGTTTTTGGCTATCTGTGATTTTTGTGAATGTAGCTACGTTAGTCGGCCGGTTGAAATTCTTATAGAAGGAAAGCTTGCGCCGAACAAAAAATATCATTTCTTCGCTGCGACTGAAAGGCTCAGAGCGATGGATTTGGAGAAGTCTTCGTTTGTATTAGATAGCAATCTCAAGATAGAAGTGACCGACTCAAAAAACCAGAATTATGAACGAATTGATAAGCTCGTAATTTCCTCAGGTATAAACTCAAATTTCTTTTATTTTGAAGAGATTCATGAAGTTGTGTGCTCTGAGCAATTTTTGATCGAGTGCGTTAATAGACAAATTTATGGACTCGCCTTCAAAAAAATTGATGGTGATTACCGATATGCTCCGTGGGATGATTTTTAGTGGATGTAATATCGATTGTTTCTGCGTGTAACTTGTGATCCCCTGATGTAAATCTCCTGAAGGGGGGCGATGGTATGCAATTCTGTCTCTCCCCATCCGGAATAGTTGTCCTCTACGAAGAGTGTGTAGACCCTTCAGCGGATGTGACCACTTCCATTTCCGCTACGACATAAGCGCTCGCACCACCTGGGTCACCGACGTGCTCAGGCGCGAAGCCGAGATCCACTACAACAGCGATCACCGCGTCACCTCCAGCCGCGACTTCGGTGGCGAGCACTACGTCATCGAGATCGACGACACCGGCAACATGACCGGCCTCACATTGCCCGACGGCAATATCGTCACGCTCAAGTACGACGAATACGCTCGACTGCTGGAAGAAACCGACCCGCTCGGGCGCAAGATCAAGTACCAGTACCATCACCTGACAACCCTGGTTACCCAGGTCGACTACTCCGACGGCAGCACCTGGAAAGCCCGCTACGACGCCAAGGGCAACCTCATCGCCGAAGTCGACGCGCTGGGCCACAAAACCGAATACCTCAACAGCGATGACGGCCTGCCGCACACCATCATCGACGCCACGCAAAAATCCAAATACCTGTGGTGGAACACCCTGGCCCAGGTCGAACGCTTCCAGGACTGCTCGGGCAAAAACACCCTTTACCGCTTCGACGAGCGCCATCACCTGATCGCCGTCACCGACGCGCTGAACCAGACCACCACCCTGGAACGCAAACCCGACGGCGAAGTCCTGCGCATCCAGCACCCGGACGGCAGCACCGAATCCTTCACCTACAACGCCCTCGGCCAGGTGTTGACGCACACCGGGAATAAGAACCCGGCTAGTGAATGTACGGAGCGGGCTTGCTCGCGAAAGCAATTTTATAGTCAACATTGGTTTTGACTGGTGCACCGCCTTCGCGGGCAGGCCCGCTCCCACAGGGAGTTATGTCGATCACAACATAGTGGACAGACGCATTGCCCTGTAGGAGACCACCCAGCCTGCGAAGAGGCTGCGCTTTCGCGCAGAGAACATGCCGCTAAATCGGCAAGTAATTTATCTAAAAAATCAATGAGATAAACTTTGTTCCATAAGAGCCGGCTTGCTGGCGATGGCGGCCGAGAGATCATCGTTAGACTTCCCGCCGCCTTTGCGGGCAAGCCCGCTCCTACAAGTTTTGTGCGTCGAGCCGGATTTTGCGGCGAGATCTTCTAGCGCGAAATGATTCCGTGATCGATCGCGTACTTGACCAGCGCCGCCGGTTTATCGATGTTGAGTTTGCGCCGGATGCTCAGGCGATGGGTTTCCACGGTGCGCACACTGATATCCAGTTCCCGGGCCATTTCCTTGTTGTTCAGCCCTTGGACCATTTTGTACAACACCTGGCTCTCACGGGGCGTCAGTTCGTTGTCGGCGCTTTTGTCGGCGATCAGCCGCTGGGCGATTTCGGCGCTGTAGAAGGTGCCGCCGCTGGCGATGGCTTCGATTGCCGCGATGATCTCCCTGGACGGCGAGTTCTTCAGCACGTAACCGCTGGCTCCGGCTCGCACGGACTCGCTCACGTATTCGTTATTGTCGTACATGCTCAGCATCAGCACCTTGAGCGACGGGTACTGGCTGCGCAGCACCCGGGTCAGTTCCAGCCCGTTCATGTCCTTGAGGCTGATGTCGACCAGCAGCAGGTCCGGCTGGCAGCGGCCGACCATCTCGATCGCATCGGCGCCGTTCTCGGCTTCGCCCACCACTTCCAGGGGAGCCATCACCGCCAGCAGCGCCTTGATTCCATCGCGGACCAGGGCGTGATCGTCGACCAGGGCGACGCGGATCGGGTAGGGCAGGTTCATTGCAGGCATTCACTCTTGTTGTGGGCACGACTCAGCGTTGGGTGCCGGGCATTTGCATCGGTAGCAGGACGTCCAGTTCGCTTCTTCCCGGCGTCGAGGTCAGGGCGAACTGGCCGCCAAAATGTTCGACGCGTTCGCGGATATTACGCAGGCCGATGCCGGCGTGGCGACGTTCGACCTTGGCGACGTTGAAGCCGATACCGTCATCGACCACCGTCAGTCGCACGCCGTCTTCCGAGCCGTGCAGGGTAATGGATACGTTGCGGGCCCGGGCGTGGCGTTCGATGTTGGTCAGGCCTTCCTGGACGATGCGAAACAGCGAGACCGCGGCGCCGTCGACCAGGTCGCAGGCGAATTCGTTGTCGTCGTAGGTCACCACCAGGCCGCTGCGCTGCTCGAATTCGGCGGCGAGCTGGCCGATCGCCGCCGGCAGGCCCAGGGTGTCGAGCAAGGATGAGCGCAGGTCGTGGGACAGACTGCGAACTTCGCCGATCGCATCCCCCAGGCGTTGCGTGGCTTCCCTCAGGATGCCCAGGCCCTTGTCTCGTCCCTGGTCATTCTCCAGTACATGGCTGGCCAGTTCGAACTGGAACTTGATGGAGACCAGGACCTGGCTGATGCCGTCGTGCAGTTCACGGGACACCCGGGATCGCTCTTCTTCCTGCAGGCTGACGATGCGTTGGGTCAGGCGCTGCAGTTTTTTGTCGGCCAGGCGGTGTTCGCTGACGTTGAGGGTCATGCCGCTGGCGAACACCAACAGCACCGCCACCAGGGCCACGGCGGCTATCGCCAGCATGGTCTTGCGGATGCCCATGGCCACTTCGTCACGGGCCTGCTGGGTGGCGCGTTCGACGTCTTCCAGGTAGATGCCGGTGCCGAGCATCCAGCCCCAGCGATCCAGCATGACCACGTAGGCGAGCTTGTCGGTGACCTGGCCGGAGGAGGGTTTGTTCCAGGCGTAGCGCTGGAAGCCTTCGCCGGATTGCGCAGTGTTGAGCAAGGCCTGGATCACCGGCAGGCCGTGGGGGTCTTTCATGTCCCACAGGTCTTTGCCGACCAGATCGGACTGGCGCGCGTGCATCAGGCTGCGACCTTCGCGGTCGTAGACGAAGAAATAGCCGTTGACGCCGAAGCTGAGCTTGCGCAGCTCTTCCAGCACTTGCTGCTGGGCGCGCGCGTCACCGTGGCCGTCGTCGTACAGCGGTTCGATCAGGCTCTGCGCCATTTCGACGTAGTTTTTCAGTTCGGCGCGCTTGCTGGCCAGGATGCTGTCTTCGATCAGTTGCGCCTGTTGATCGCCCAGTTGACGGTTCAGGGAGATGACCAGGGCGCAGATGACGGCGATCGCCAGTACCAGCGGCAGGATGCCGAGCGCGACGATTTTGTGTTTGAGCTGCATCTGGGCTCCTGACCGGGCCGAAGGCGGGCGATGACGCTAATACTGTAGGAGCGAGCTTGCTCGCGATGGTCGTCAACGAAAACGCGTGTTTACCGGGTATACGCGGTGTTCTGAAGTCCATCGCGAGCAAGCTCGCTCCTACAGTTCCTGGGCGGGCATCATATGCCAAGGAGTGCGGGTCCAGTAGCGGTGGTGGACGGAATGACCTGCTGCCGGGATCTGTCGGTTGAATGTAAAACCCCCCTGTAGGAGCTGGCTTGCCAGCGAAGGCGGCGGCACATTCAATATCAATGGCGACTGACACACCGCTTTCGCTGGCAAGCCAGCTCCTACAGGGGATTTGTGTTTCAACCGATAGATAGGGGCGATCTACGTAGAACTACGTAGAGGTCGCGTACGTAGTAACGCGGATTTATTTGTGGACGGCATGCGCGGATATTGGGCCAGCTCCGCTCAGCGGACACAATTATAAAAATTACCGCCGCAGTCCACTGGCTGTCGGCAGGAGACACGCTATGCCCCGTCTGGCTAAACACCTCGCCTGGTTTGCCGTGGCTGTCCTGGGAGCGTTCGCGCTGAGTGTCGTGGCCCTGCGCCGCGGCGAAGCCATCAACGCCCTCTGGATCGTAGTCGCTGCAGTCGCCATCTACCTCGTTGCATACCGCTACTACAGCCTGTTCATCGCCAATAAAGTGATGCAGCTCGATCCCAATCGCGCTACGCCCGCCGTGCTCAACAATGACGGCCTGGACTTCGTGCCGACCAACAAACACGTGCTATTCGGTCACCACTTCGCGGCGATTGCCGGCGCGGGGCCCCTGGTCGGACCGGTCCTGGCGGCACAGATGGGCTACCTGCCCGGTACGCTGTGGCTGATTGCCGGGGTGGTGCTGGCTGGCGCGGTCCAGGACTTCATGGTCCTGTTCCTGTCCACCCGCCGCAACGGTCGTTCCCTGGGTGACATGGTCCGCGAAGAAATGGGCCGCATCCCCGGCACCATCGCCTTGTTCGGCTGCTTCCTGATCATGATCATCATCCTCGCGGTGCTGGCGCTGATCGTGGTCAAGGCCCTGGCCGAAAGCCCGTGGGGCATGTTCACGGTGATGGCGACCATCCCGATCGCGATGTTCATGGGCATCTACATGCGCTACATCCGCCCGGGCCGCATCGGTGAAATCTCGGTAATCGGTGTCGCGCTACTGCTCGGTTCGATCTGGCTCGGTGGGCAGATTGCCGCCGACCCGGTCTGGGCCAAGGCGTTCAGCTTCACCGGCGTGCAGATCACCTGGATGTTGATCGGCTACGGTTTCGTTGCGGCAGTGTTGCCGGTGTGGCTGATCCTGGCACCCCGTGACTATCTGTCGACCTTCCTCAAGATCGGTACCATCGTCGCTCTGGCGATCGGCATCCTGGTCACCATGCCCGAGCTGAAAATGCCGGCCCTGACCCAGTTCATCGACGGCACCGGCCCGGTGTGGAAGGGCGGTCTGTTCCCGTTCCTGTTCATCACCATTGCCTGCGGTGCGGTCTCGGGTTTCCACGCGCTGATCGCTTCGGGCACCACGCCCAAGTTGCTGGCCAGTGAAGGCCATGCCCGTTACATCGGGTACGGCGGCATGCTGATGGAGTCCTTTGTGGCGATCATGGCGATGGTGGCCGCTTCGGTGATCGAGCCGGGTGTGTACTTCGCCATGAACAGCCCGGCAGCGATCGTTGGCTCCGATGCCGTTACGGTGGCACAGACCGTCAGCAGCTGGGGTTTTGCGATTACTCCGGAAGCGCTGGAAGCGGTGGCCAAGGACATCGGTGAAACCACCATCCTGGCTCGCGCCGGCGGTGCGCCGACCCTGGCGGTCGGTATCGCGCAGATCCTGCACAGTCTCCTGCCGGGTGAAAACACCATGGCGTTCTGGTACCACTTTGCGATCCTGTTCGAAGCATTGTTCATCCTCACCGCGGTAGACGCCGGTACCCGTGCCGGCCGCTTCATGCTCCAGGACTTGCTCGGCTCCTTCGTACCGGCGCTGAAACGCACCGAGTCCTGGACCGCCAACCTGATCGCCACCGCCGGTTGCGTGGCGATGTGGGGTTATCTGCTGTACCAAGGGGTGATCGACCCGCTGGGCGGCATCAACACCTTGTGGCCGCTGTTCGGTATCTCCAACCAGATGCTGGCGGGGATCGCGCTGATGCTGGCGACCGTGGTGCTGATCAAGATGAAGCGTCAACGCTACGTCTGGGTCACCATGCTGCCCGCGGTCTGGCTGCTGATCTGCACCACCACCGCCGGCTTCATCAAGCTGTTCGACGCCAACCCGGCGATCGGCTTCCTGGCGCTGGCGAAGAAATACAGCGATGCCCTGGCCAACGGTCAGGTGCTGGCACCGGCCAAGAACATCGACCAGATGCAGCACGTGATCTACAACGCCTACACCAATGCCACGCTGACGGCGCTGTTCTTGTTGGTGGTGTTCAGCATCCTGTTCTTTGCGCTCAAGGTCGGTATTGCTGCCTGGGGCACCAAGGAACGTACGGATAAAGAAGCACCGTTCCAGGCCGTGCCGGATGCTTGATCGAGGAGTGCAGCATGTTCAATGACCTGAGTCGCCTGGGTAAATACCTCGGTCAGGCCGCACGCCTGATGGTTGGCATGCCCGACTACGACAACTACGTCGAGCACATGCAGAACAAACACCCGGACAAACCGGTGATGGACTACGAAATGTTTTTTCGCGAACGGCAGGAAGCCCGTTACGGCAGCAAGAGCGGGCCGAAGTGTTGTTGATTGTCGACAAGGTTCTTTATTGAACTTGTTTTAATACGCTATATCGAAAACGCCGCTCATTGAGCGGCGTTTTTCGTTTGCGCGGGATAAAAAAAGTTCGCAACTAAACATATAGCCGCTCTATTTCTCTCCTGATGATCGACATCATGTTGACGCCAAATATTTGTACTGTGCGATTGCATCTAAAAGCGATTGAGCATAGTGCAAAACAGTTGTGCACGTGATTGAAGTGTCAGCCATAAATAACAGCGAGTTCAGTCAAATCAATCGCTAAGCGGTTCTGTGAGCCAGCGGATAAGGAAGCGACAGAAAACTGACAATCAATAAGACAGTCCTATCCCCCTATAAGTCGGTGATACATCATGATCAAGATCATGGCGTGCTTTCTCATAGGAGCTCTAACTGCAGGATGCAACGGCATCGTTAAGCCCGACCTTTCAAGGGCTACCAGCGATTCATACTTTCTAGTCTTCTCAGGCTTCCCTCTGCCCTATGTCTATATGGCTTCGGCGGTGCAGTGGAACGAGGATTACGCCGTCACCACCCGCCACACGCCGTTGATCCCCAACGTGAAGTACAGCTGCAGCACTGGTTGCGATCTGGTGTTCTTCCAGCACAAGGCTAACGGCCGCTACCCGTCCTGGCGCGCACCGCGTGTGGGCGAGCGCATCACGGCCGTGGGGGGCAGCCCTTATCTGATGACCACCATTGGTAAGGGCAAGGTGTATCCAACGCCTTTCATCAATACCAATGAACGCAGCGGCGATCTGTACGCTATCCATGATGCCCCGTTGATCAAGGGCATGTCGGGTGGGCCGGTGGTCGCCAGTGACGGCAGTGTCGTCGGCATCAATATCGGTTTCTATTCCACCACATTGAACGATGTGAGCGCCCACCCCGGGGTCAATACCGCCGAGAGGATGAGTATCTTCGTGCCTTACTCGATCATTCTGCGCGAGTGGGGGATGTTGCAGGCGAAGCTTGATGATCCGCACGGGACGAAATACGTCTCGAAGTAGGGGGTAACGCTGTTCATTGTAGGAGCAAGCTCGCTCCTACAAAGGCCACCTGTCACCAGTGTCGGCTGAGGCCTGGTCGCATCGGGGGGATGAATTCGAGCGTTTGCAGATTCAGCAGGGTGAAGTGACCGCGCTCCGGCAGCCAGCCACCGGTGTCGATGTGGTAGACATTGCCCAGGATGACCGGCTGGGGCAGGGGGGTGTGTCCCACAACCACGGCGCGCACACCGGACACGCCGCCAGGATCGCTGTCGGTGATGCGCCGGCGTGACCACTGGAGGGTCGTGGCGATCTGTTCAACCTCCATCGCCAAGCCGGATAGCGCTTCAGTCATGTCTTGCCAACTGCCCGGTGGGACATCCGCGTGCACGATGCCGATCAGGCCTTGCGGCGTCTGAACCTCGATCACTAAAGGCAACTCGGCGAGGATGCCCGCGTAATAGGCTTGCTCGGTCCCCGACAGTCCGTAGAACCAGGCGCCACCATTGGCAAAGTGCAGGCCGCGTTCAACGCTGGCGCGGCCGGCGGCGTGGGATTTGACGGTCATCTGCTCATGGTTGCCCCGCACCGCATGGAACCAGGGCTTGTGCAGCAGCCATTCATCGACGTCCAGTGTTTGCGGCCCGCGGTCGACCAGATCGCCTACGCTGAACAGGCGGTCGATAGACGGGTTGAATCCGGCAGCATCGAGTGCCGTCTGCAGTCGGGCGAAGTGGCCGTGAATGTCGCCCACGGCCAAGTCGCGGCCGACAGGATTGGCGGCGAAGCGCCGCACTTCTCGGGTTTCGAACATGGGAATGCCTTGCCCACCACACACCGGCGGGCTGGTAGTCCGTTGAGTTTAGGCCAGGAAGTGCGGGTTGATAGATACGGTGTCGGTGTCGGTGCCGGATTGGCTGGCGAACAGCACGCCATCAAGCGACCCGACACCGATCAGGCGGCGTCAGAAGCCGATAGCTTGTCCGGGATTGTTGTCCTGCGCGCCAGCGATGAGGTGCAGGGGAATGTGTTGCTGTTCATCGATGGATGAGACTTCAAAACCTCCCACCACCTGGGGCTGTCGCTCGCACACTTCGGTCGACTCTCCTGCCAGTATTTTAGCCATTCTTGCGTGATTCGCGGCGATTTCATTGAGAGTTGACATGGTACATCCCCCGGGTGACTGACCAAGCGTATCGCTGGAGTCCTTGAACATTGAGTTGAGTGCTGCCGCGTCAGAATTACGTCGATCTGGGGCTGCTACGACCGGCCTTTGCAATCCTTGAGCCAGAGAGGGTTGGGTAATTGACGCTACCCCTAGCATAGGCGACGAATGGTGGGTTTGCGTTAAAAAGACGGGTGAATTGTGGTCAACGCCATCCCCCTGTAGGAGTCTGCTTGCTGGCGAAGGCCTCTGCATGGGCGCTGCATGGGCTCCAGGCCGCCAGCGACCATTCGGGCCAATTCGCCAGAAGTAATGCGATTTCGATATCTACGGCAAGCAATCAGCGGGCGTCGTTACGGCACGCATGCTCGTACATGCGCCGTTGTTTTAGTTGCGGGAAGTCGAGCTGCACACCAGGGGCGGATCATGTGTAGCCGTCACCCTCGATCTCGCCCGCAGGGTCGATCACCTGGGCGCTCTGGTTGCGAACGTTGCCAATTGCGCGGTCCACCTTGAACCACTCGAAGGCCTCGGTCGGCTTGCCTTGAAACAGCGCCATGTGCTCGGCGCGCTCCATGGGCGTAGCGGGCTCCAGCCATTCCCGGGCCAGTTCCGGCGATAAGGTCACTGGCCGCCGGTCGTGGATGTCCACCATGCCGCCGGCGCTGTCGGCGGTGATGATGACGAAGCCGTCGTGTTCGCCCGGCTCGTGCTCGGCGTTGGGGTACTGGCCGATCGCGGCGCAGAGTATTGGCGTCCGGTCACGGTGACGGATCAGGTAAGGCTGCTTCTTCGGTCCGCCTTCGTCGACCCATTCAAACCAGTTGTCGATGGCGATGATCGCCCGGCGCGGCCAGATCGCTTTGAAGAACGGACCATGGGCCACTTTCTCGACCCGGGCGTTGATCGGCGCGGCGCGGTCCTTGGCCCAGTGCGGACGCCAGCCCCAGCGCACCAGATCGGCGCGCAAAAACTGGCCTTCCTGGTGAAAGAGGGCGAGTTGAGTGGTCGGCGCGGCGTTATAACGCGCCAACGGCTGGTCGCCGACATAGTTGATCAGGGCGTTAGGAATGGCGAGCGCCGCGACGAAATCGTGAATGCCCCGGTACTGGGAAAGGCGTCCGCACATGATGTGTTCTCCGGCTGTGTCTTCAGCGTAGCCGAGGCGAGAGACTTCGAGGCGTGACGATCGGGCGAGGGTGGGGCGGCGGGCTGAAGATTCAGGAAATGAAGCTTCGCCCGCCGCTGAAGCTGTCAGGCCGCAGCATCCACCGCTACGCCACCCTTCCTCATCGGCACATCATGCAGGGAAATCCTCGAAGTCTCCGGCAACGCCAAACCACCGGCCAGCGCGAGCAACGCAACCGCCATCAGATAGAACGCTGGCGACAGATTGCTGCCGGTGGTGCTGATCAGCCACGTCGCCACCAGCGGCGCGGTGCCACCGAACAGGGTGTAGGCCATGTTGTAGGTGATCGCCGATGCCGTATAGCGAGTACGGGTGGGGAAGGTTTCCGAGAGCAGGGCTGCAGTGACCACGCCACACAACACCGCGCCGATCGCCAATAGCATGACGCCGACGATGGACGCGGCGAACGATCCGGAACTGGCCATCAGGAACGAGGGATACACCACCACGATCAACAGGGCGCAAGCGGTCATCACCGTCGCCCGACGCCCGACGCGGTCCGAATACAGCCCGGCCAGCGGGCAGATCGCCGCGGCGAAGATCAAGGCAATCAGCGACACCAGCAACGCCGTTGCGCGACTCAGGCCGCCTGCGACTTGCAGGTAGGTCGCGAAGTAGGTGGTGAACATATAGAACGACAGCGCCGTCAGCGACACGAAGGCACCCAGGCAGCAGATCGCCGCGCCGTGGTTGCGCAAGGTCTCCTTCAACGGGGAGTGTGCCACCGCATGCTCCTCGGTCACTGCCTGGAATGCCGGGGTTTCATCCAGCTTCCAGCGCAGGTAAAGCCCCACCAGGCCCAGCGGTGCGGCAATCAGGAACGGCAGGCGCCAGCCCCAGCTACCCATGGCTTCGGCCGATAATGAGGCCTCGAGTGCGTAGGCCACCACGGCGGCCGCGGCGAAGGCGGAAAAGGTCGAGACCGGAATGAAGCTGCCATACCAGGCTCTTTTATCGTTGGGTGCATGCTCCATCAAGTAGGCGCACGCCCCTGCGTATTCGCCCCCGGCGGAAAAGCCCTGGGCGCAACGGATGACGGTCAGAAGGATCGGCGCCATGACCCCGATGGCGGCATAAGTGGGCAACACCCCGATCAAGGTCGTCGCACCCGCCATCAGCAGGATGGTCATGGCCAGGGTTCTCTTGCGGCCGATCCTGTCACCGAGCATGCCGAAGAAAATCCCGCCCAGAGGCCTGAACGCAAAGGCCACGGCGAACACCGCGAAGGTTTTCAGCAAGGCGACACTGGCATCGCCGCTGGGGAAAAATTGCTGGGCGATGGTGGTCGCCAGAAAACCGTAGACGGCGAAGTCGAACCACTCGACGAAATTGCCGATGCCGGCGGCCACAATGACTTTTCTCAGTGTTTGCGGGCTGACCTGAGCTGCGCTTGTCATGCTGGACCCTCGACATTCCATTAGTAGGCTTTCGATTATCGGGGCAGCGACTGGAACGGCTCACTTCAAAAGTGTCATCCGCATAGTCAGGACCGACCCATAGCGATTGGGGTACGCATGATTCGTGCCGAAGGGCTTGGATCAAGGCTTGATATGAAACTACCGATGAGCCTTGCCCGACTTTAATAATGAGAGGTTATTAGCGTTACAGTAAAACAATCATTGAGCGTTTAAAGTTATTTGTTGTTGTATTTCGAAATTTTATAACTATCGGGTATTTCCCTTTGGCAACAATGCTTTAAGTTCAGGTATTTGCCGCTCGGATTATGTCATGGGGCCATTATCGGGTTGCAGAATGCTTTATTTGCATAATAAAAAATACGATCTATAGCTATCCATACCTTTCGGATCGTGGGCACGTCAATTTCCCCCCGGGAATTTGAACCGCGTCCAGGTCATCAACGATTTCCGGGCAGTGAACGGGTCCGGATGCAGTTGTGTTGGTTGTGAGGCGAAGTTTTATCTGCCTCTGAAGGGATTAGGGCCATCAACCTCCTGCATCCTGTACGGAAAGGATCCCCCATGCCTGTCCAACTCAGCTATCCAGGCGTCTATATCGAAGAGCTTCCCAGCGGCGTGCGAACCATTACCGGGGTCGCGACCTCGGTGGCGGCCTTTGCCGGTTCGGCGCCTCGCGGGCCGATCAATAATGCCCAGCACCTGTTCAGTTTCGCCGATTACGAGCGGCGTTTCGGCGGCCTGGCGGTGGATTCCGAGATGGGTTATGCGGTCCGCCAGTTTTTCCAGAACGGCGGCACCGAGGCTTACGTGGTGCGTATCGTCAAGGACGCCAGCACCGCGAGCAAAACCTTGCAGAACGCGACGCCGATCGACGTGCTCAAGGTCCAGGCGCTGGACGAAGGCGCTGCTGGCAACGGTATCGAAGTGCGGGTTGATCACCTGACCATCAACCCCGGTAGCTCATTCAACATCACGTTCATCCGCGCCTCGGATGGACGCGCCGAACGCTATGAAAATCTGTCGATGAACTCGATGGACGCCCGCTACGCGCTGGATCAGGTCAATGCTGTTTCACAGTTGGTAAAACTGAGTCGGATGGTCGGTCAGTCGGCGCTGGACGGGTTGGCCGCCGGCACTTCGCGCAGCGCCAACCTGGCCGATGTGACGACCCTGCTGGACGCCAACCACAACGAGTTTCGGGTCAGCGTGAACAATCTGCCGCCGGTCAAGGTGCTGATCGCACTGCCGGCGGATATCGCCGGCGGCACGGCGACCCAGCGTCTGGATTCACTGTGCGGCGCGATCCAGACCAAGGTCCGGGCGCAGGCGAACAGCCAACTGGCCTACCAGAACTTTACCTGTGGGCGGCCGGCCACTACGCAAACGATCCTGATGACGTCCGGTGTCGGCGGCGAATTCTCCAGTGTGCGGGTGCTGCCCGGGCAGAAGAGCAATGCCAGTGCCGCGCTCAAACTGGGCAGTGAGGCCGGTGGCGTCGAGGTCGACGCGGTCGGGGCGATCCGTCCGGTGCCCGTGCCTGATCCGGCGACCCTGACCAGCGATACCTTCGGTGCCAACGACCTGGATGCACTGCCGGATGCGACCCACACCGGCTTGCGCATCAGTCTCGATGGCAATTCCGACGTGATCGATATCGGTGACGCGCTGGCGGTTGGCGGCAACCTGGCTGACAAACTGAGCGACATGGCCGCGCGGATCCAGGCGGCGGTGCGTGCGCGCAAGCCGGGCGATCCGGCCTACCGCAACTTTACCTGCGCAGTGGCCGGCAGCACCTTGGTCCTTGCCACCGGCACCCGGGGCGCGGCCTCGAGTATCGCGGTCTCGGCTTCGCCGCTGAACAGCATCGCCAGCCAACTGCACTTGCTGGCGGGCTCGCTCACCACCCAGCCGGTGAACGTCACGCTGCAGGGTGGCAGTGAAACAGCCTATGCCGCTGCGGATATCTATGCCGCCTTCATTGCTGACCGTGACACGCGCAAAGGGTTGTATGCCCTGGAAGCAGTGGACCTGTTCAACATCCTCTGTCTGCCGGGCATCACCGACGCCGGCGTGCTGATGGATGCGGCCGCCTACTGTGAGGAGCGTCGGGCATTCTTTGTGATCGACTCGCCGCCAATGGCTGTCGATCCGCAGCAGATGGTGGCGACGGTATCCGGCACCGCGTTGCCAAAGTCCGATCATGCCGCGGTCTACTACCCCTGGATCTACATTGCCGATCCCCTGAAAAACGGCAAGCTGCGTCTGAGCGCACCTTGCGGCACCGTGGCCGGGCTTTACGCCCGCACCGATGGCGACCGTGGTGTGTGGAAGGCGCCGGCCGGCACTGAAGCCAGCCTGATCGGGGTGCAGGCGCTGAACTATCAATTGAACGACCGCGAGAATGGCAGTCTCAACCCGTTGGGGGTCAACTGCCTGCGCAGTTTTCCGGTCTACGGCGCGGTGTCCTGGGGTGCCCGGACCTTGCGCGGGGCCGACCAGATGACCTCGGAATACAAGTACGTGCCGGTGCGCCGACTGGCCCTGTTTCTCGAAGAAAGCCTGTATCGCGGCACTCAGTGGGTGGTGTTCGAGCCCAATGATGAGCCGCTCTGGGCGCAGATCCGGCTCAACCTCGGCGCCTTCATGAACAGTCTGTTCCGCCAGGGCGCCTTCCAGGGTAAAACGCCGCGCGAGGCCTATCTGGTCAAGTGCGATCGCGAAACCACCACCCAGGACGACATCAATCGCGGCGTGGTGAATATCCTGGTGGCGTTCGCACCGCTGAAACCGGCGGAGTTCGTGGTGATCAGGATCCAGCAGCTGGCTGGGCAGATTCAGGTGTGA

Protein sequences of DBSCAN-SWA_1

>NZ_CP014870|2473630:2519090|2505523_2506351_+|WP_082930300.1|DBSCAN-SWA
MLSLPIRNSCPLRRVCRPFSGCDHFHFRYDISARTTWVTDVLRREAEIHYNSDHRVTSSRDFGGEHYVIEIDDTGNMTGLTLPDGNIVTLKYDEYARLLEETDPLGRKIKYQYHHLTTLVTQVDYSDGSTWKARYDAKGNLIAEVDALGHKTEYLNSDDGLPHTIIDATQKSKYLWWNTLAQVERFQDCSGKNTLYRFDERHHLIAVTDALNQTTTLERKPDGEVLRIQHPDGSTESFTYNALGQVLTHTGNKNPASECTERACSRKQFYSQHWF
>NZ_CP014870|2473630:2519090|2513438_2513639_-|WP_082930470.1|DBSCAN-SWA
MSTLNEIAANHARMAKILAGESTEVCERQPQVVGGFEVSSIDEQQHIPLHLIAGAQDNNPGQAIGF
>NZ_CP014870|2473630:2519090|2511278_2511476_+|WP_064677253.1|DBSCAN-SWA
MFNDLSRLGKYLGQAARLMVGMPDYDNYVEHMQNKHPDKPVMDYEMFFRERQEARYGSKSGPKCC
>NZ_CP014870|2473630:2519090|2494059_2494644_+|WP_064677244.1|DBSCAN-SWA
MVRTSIYDRISEKRLAAEALARQLQQQAADAPPAVIEPEPIVKVPLQLARNGLTVAGLNLLIPDGFNFRDIDTTLEKYGHPVTFGAKRRPAPEGLTLRRAVELYVEKLRQDHPDVTIVRQSDGVLAGHRAIALDYIFTAGQERRHGRAMSAVIESDNGNERQCFSISTMINPAHAELADWLIEFDAMLESVSAD
>NZ_CP014870|2473630:2519090|2485234_2486932_+|WP_082930298.1|protease|DBSCAN-SWA
MEFVLARDSKSDAAIEPIAGRMSSGEFKLVGIALVVMLGCLYSIWQMGKQLRVMLHMFESTPMPVLGQVVTPEQAPVLWAYVRDLADQLGALAPEHIVLGMTEGFYVTSSDINLLPSDTALQGRTLHVPMLYLRLLDRAETSAVIGHELAHFAGADTEYSQRFLPIYDGIGRSLGVIGETMQQSDLLQRSILRPAFMLGIYFMERFDHAVNHWSRVRELAADAAGARLAGNIAAASALLRISAIDPLLQECVGTHVGHATNPTEHALTRDLPTSVLHELAAQPLTLPEEELATRLPHPTDTHPSNGERVASLQVSLEEAVSRGTRPIVAAQACAALDQYFADPQALRRRVTEDFLNHYVTQDVALVEELRTHASQATEEVRLHEGARVRGWISLVFFGTLMVVGLGLLVWSLLFPEAAGSKKGVLLAAGGVLTFMMACMLPMSLRLLMRADKTALLLTPEHFVFANLKAPLPIQHVADFGLRVGQGVHLNLLLEDDAPMPELSSRSFFAPDVKLDKKKRWVQLQLMQFCRDDRKLKEKELAELIGTYLNAGTARHLLQQRFEQVD
>NZ_CP014870|2473630:2519090|2479382_2481215_-|WP_064677234.1|plate|DBSCAN-SWA
MLDDLLPYYEKELSHLRFLGQEFASQYPKIASRLLIEGDNCEDPHTERLIEAFSFLSARVHKKLDDELPEIVESFLEVLYPHYLRPTPSMSIVEFNLGKQEKVTEAFHVARHTELSANPIDGVVCKFRTCYPVELWPVAVHQASFIEMERSAFNGHSADLVARLRIGLRATSDVMFGKMELDRLRFFLDGESTLMLQLYELLFNNLAKATVSFEDQGRTREVALPANALKAVGYGVDEGLVDYSERSFLGYRLLHEYFTFPDKFMFFDLSGFSRLLAGQNLENIEINFYFSDYDLSDRLARLTQNIGRNNFKLNCTPIINLFRQQAEPIKLTHAQHEYAVTPDVRLQSSAEVVSIDRVRRVRKVGGLDQVDTCHPFFEPRGDQGPGQSFWIARRRPVQTRQRDGSNMVIRVVDRELELLDSSNDTLSIRLTCSNRDLPLMLPFGGERGDFNIPGNSVINDIRCLRKPTATARVPLGNGVIWRLISHLSLNHMSLVSRGRDVLLELLSLYNYRNVSAIRKQINGIVSVSSEPVVARIGHPRPNFVRGVGITLNFDESQYTGSGVFLFGMVLDHFFGQYCSMNSFTQLTLRTLQREKRVVQWPPRTGDQPLV
>NZ_CP014870|2473630:2519090|2487071_2487356_-|WP_082930469.1|DBSCAN-SWA
MPQPVKEALHHNDRLLILVEPAPDVIFNRNIFALSMHGELLWQIEESPHGTEVDKPYMNLHCDKNGVVIAGNWNGLSYSVDLHNGTVSVAAFEK
>NZ_CP014870|2473630:2519090|2475748_2478352_-|WP_064677232.1|DBSCAN-SWA
MNLKSLFAKLNDTSRTATESAAALCLSEQHYDVEIEHLLLQLLDSHDNDLPAILRHYDVVPERLQAQLVTALGTFKKGNTRTPALSPHITRMIEQAWVLASIEFGQGQIRTGYLLQALLDDNELRRVVIASAPELEKINADDLRVNLGALVEGSAESQQAKPLAGADVTARGTVKGNGKTPALDQYTINLTQSAREGRIDPVLGREFEVRQMVDILTRRRQNNPILTGEAGVGKTAVVEGLALRIIQGDVPSVLKDVAIHTLDLGLLQAGAGVKGEFENRLKSVIEETKRSLHPIILFIDEAHTLIGSGGQAGQNDAANLLKPALARGELRTIAATTWAEYKKYFEKDAALARRFQVVKVEEPDEDKAIHMLRGLLGKMQDHHKVTVMDEALVQAVRLSSRYITGRQLPDKAVSVLDTACARVALGQSAQPGPLEDCKKTLDNLQAEIAVLQQEAAKGSDHARRLATLQTELQAGQHTRETLEQQWQRELQLVEKLGALSHPDNQAPDVREIAAVRAELASVQGEQPLVHALVDGGTIGEVISGWTGIPLGKMLRDEIDTVQRLPALLGERVLGQDHALQEIGKRIKVSRARMEDPNKPIGVFLLLGPSGVGKTETALALADTLYGGERNLITINMSEYQEAHTVSSLKGSPPGYVGYGEGGVLTEAVRRKPYSVVLLDEVEKAHPDVLELFFQVFDKGVLDDGEGREINFRNTVIILTSNTGTEHIMQACLNAGQQPTPDEIVEGLREELNQVFKPAFLGRLTIVPYYPVKDAILERIVALKLERIRQRFERNHQAVLSYDAALVKAIAARCTEVDSGARNIDNILSKTLMPELAQQVLERMAQDTPIQSLHIEMDSDGDFACRLS
>NZ_CP014870|2473630:2519090|2483235_2483769_-|WP_064677237.1|DBSCAN-SWA
MAKKESTQHKLDRVRAPRVHITYDVDIGDAQEKKELPFVVGVLGDFSGNPLEPLPKLKDRKFIFIDRDNFNGVLKGIKPRLSYRVDNTLVSNGTQLGVELNFNTLEDFEPQNVVKQVEPLRKLLEVRNKLADLRNKMGGNDKLEELLMDVLQNTEKLKTLGKEFGREAAVPATDGKE
>NZ_CP014870|2473630:2519090|2511838_2512495_+|WP_064677254.1|DBSCAN-SWA
MIKIMACFLIGALTAGCNGIVKPDLSRATSDSYFLVFSGFPLPYVYMASAVQWNEDYAVTTRHTPLIPNVKYSCSTGCDLVFFQHKANGRYPSWRAPRVGERITAVGGSPYLMTTIGKGKVYPTPFINTNERSGDLYAIHDAPLIKGMSGGPVVASDGSVVGINIGFYSTTLNDVSAHPGVNTAERMSIFVPYSIILREWGMLQAKLDDPHGTKYVSK
>NZ_CP014870|2473630:2519090|2509206_2511264_+|WP_064677252.1|DBSCAN-SWA
MPRLAKHLAWFAVAVLGAFALSVVALRRGEAINALWIVVAAVAIYLVAYRYYSLFIANKVMQLDPNRATPAVLNNDGLDFVPTNKHVLFGHHFAAIAGAGPLVGPVLAAQMGYLPGTLWLIAGVVLAGAVQDFMVLFLSTRRNGRSLGDMVREEMGRIPGTIALFGCFLIMIIILAVLALIVVKALAESPWGMFTVMATIPIAMFMGIYMRYIRPGRIGEISVIGVALLLGSIWLGGQIAADPVWAKAFSFTGVQITWMLIGYGFVAAVLPVWLILAPRDYLSTFLKIGTIVALAIGILVTMPELKMPALTQFIDGTGPVWKGGLFPFLFITIACGAVSGFHALIASGTTPKLLASEGHARYIGYGGMLMESFVAIMAMVAASVIEPGVYFAMNSPAAIVGSDAVTVAQTVSSWGFAITPEALEAVAKDIGETTILARAGGAPTLAVGIAQILHSLLPGENTMAFWYHFAILFEALFILTAVDAGTRAGRFMLQDLLGSFVPALKRTESWTANLIATAGCVAMWGYLLYQGVIDPLGGINTLWPLFGISNQMLAGIALMLATVVLIKMKRQRYVWVTMLPAVWLLICTTTAGFIKLFDANPAIGFLALAKKYSDALANGQVLAPAKNIDQMQHVIYNAYTNATLTALFLLVVFSILFFALKVGIAAWGTKERTDKEAPFQAVPDA
>NZ_CP014870|2473630:2519090|2483839_2484589_-|WP_064677238.1|DBSCAN-SWA
MTQTFDVEALIRLRSQTRAISDALKAQASDYLATLALLIRPQTFFGEYLQGAQRSSGRETQHHFKELKELYDRIGSASPFQLVNELEVPLTLISTTPELFPLEYDKVLSQSGQSIRITSPVRWVVGFSSFDLARFRTVIKDPNRSSAELHRFVVHYLVLFYCLSQSPGVGRVLEGLRFPLSFERLKYFGDLPFCVIGSPVRAQLPDESVIRSSTQIAGNTSFEELVGHENIVEMNDEIRQRLLLTIEGM
>NZ_CP014870|2473630:2519090|2474966_2475725_-|WP_082930297.1|DBSCAN-SWA
MDNRQTGKRAAQPALAKCLVAVAMMMALTACGVTDRVGKRVDDTWAGDMLFDDNEKVILTSDGGNQLNPDESGKPLSVVIRVYQLTSLERFSSIDADTLWDDPQKALGNTLLENREITLLPGMGQVDKWPLNKAAGYVGVAAFFRSEENSRWKVAFDANSLRKDGIWFSSDGLRVLVDNNTVSAMGGVDVLNKPKTEAQLAKASAQTDQPTEGSLTQRVQDAVVQQAEDTATSSAQKATESKLNSLLEGVHE
>NZ_CP014870|2473630:2519090|2488895_2490011_-|WP_064677241.1|DBSCAN-SWA
MIDLRSSNEVLAKYIERYDHLLPPPSLQLRQRMDYTLQPDAPRLPNNKPDWLTSRPCSITEEQALDRSKGCLLGLAIGDAVGTTLEFLPRDREAVMDMVGGGPFKLNPGEWTDDTSMALCLADTYLERSDFDFYDYAERLCRWYKNGENSHNGKCFDIGNATRTALEGRLTQGRDWYGNDDPSTAGNGTIIRLAPTAIYRRHSLSATLRESAAQSRVTHKAAEAVNCCELLGAQLHLALNGADKEETLSSMVRALYPRPLIINAGEYKQKTRDQIRSSGYVIDTLEAALWAVWNTDNFKDAILLAANLADDADSVAATTGQIAGALYGVSGMPKEWVSQVVWSERIQGLAQKLFERAPLHDDMDDVIYGGR
>NZ_CP014870|2473630:2519090|2487457_2487970_-|WP_161491163.1|DBSCAN-SWA
MQCAAIVSLLTHGPQSEQFLTYRKHVDYYRNSDLTREQVQLFDDYVASRSYHTTVAGEDHLLKTPITALDYIDNAIAITALRYNRRPEFQIYSSSLIQLQFIKNVLLGVEKDNARLHQLTIGAWAGKEFEVNDPELASALGIAFYIGDQIAQGLKIQLPNGLPPESLPRT
>NZ_CP014870|2473630:2519090|2506659_2507292_-|WP_064677250.1|DBSCAN-SWA
MNLPYPIRVALVDDHALVRDGIKALLAVMAPLEVVGEAENGADAIEMVGRCQPDLLLVDISLKDMNGLELTRVLRSQYPSLKVLMLSMYDNNEYVSESVRAGASGYVLKNSPSREIIAAIEAIASGGTFYSAEIAQRLIADKSADNELTPRESQVLYKMVQGLNNKEMARELDISVRTVETHRLSIRRKLNIDKPAALVKYAIDHGIISR
>NZ_CP014870|2473630:2519090|2494681_2495143_+|WP_064677245.1|DBSCAN-SWA
MDYQLQEGSIVLPEGFQDRTVNMFVLGNSIPAPLNITISRDNMLPAEYLKTYIERQVKLIAAKLRGYTLLSKKPATLSSEQPRSGIQVDAYYMNDGRPVYQRQAAFEIEQGRILVFSTTSQADFSATQNENWLQLLTSFQPRQDTVPTDVEQE
>NZ_CP014870|2473630:2519090|2495146_2499373_+|WP_064677246.1|DBSCAN-SWA
MFEAARWGDEIEHTSALGGFLVGAVIGLAIATAAAFTICTAGLGGILLSIAAGVGASFIPAIGESMGAARSSPAGGIKLEGCSADVFINNRNAAHATLSQGACDKHPAPVLVAEGSSNVFINNVAAARKGDKLTCGAKISSGSNNVFIGGGTERYLDVDEEVPAWLRVTVDVLMIVASMGRAVGPIFRLGLTQGLKAAGPCALKFGATIAGSYLAGRFIIGPAVERAIGGLSGNPVDLTTGRKVLFESGETDFALPGLMPIEWSRFYASDLNVESVLGRGWVLPWEQSLRRSGSFVYLTDNQGRSVPFVDVEPGDRTYNPYEQIHLVRTEGGHYLLQTLDNTFFYFGEVPDDDTAVQLQRIENALGHYLHFSYSADNTLTDISAPGGVRVHLHYDNPLGRLTDVKRVVDNLAVETLVQYRYDENGQLIEVINRNNDSVRRFSYADGVMASHSNALGLTCNYRWQTLGDQPRVVEHWTSDGEHFHYRYDFNQRVSWATDVLGRELEIQYNEDRRVIASRDYGGECYGIALDEAGNMTGLNLPDGNKLAFKYDDFSRLMEETDPLGRKIKYKYHLSTTLVTETTFMDGSTWKARYDAKGNLIAEVDALGHKTEYLNSDDGLPHTIIDATHKSKYLWWNTLAQVERFQDCSGKSTHYRFDERHHLIAVTDALNQTTTLERKPDGEVLRIQHPDGSAESFTYNALGQVLTHTDGKGQTTRLLRTARGLPSSRQDAKGQRIRYEYDQAIRLTALVNENNAAYQFAYDASDRLVEEKRIDNLTRQFSYNLGGHLTRVDEIGYGERGERPQRHTEFERDPIGRLLAKLNADARQDYTYDDADRLLTIERLPTANGKKLGVSAEKLDFSYDLLGRLIKETTPQGELAYDYDPLSNLTTLTLPTGQHLNHLYYGSGHLHQLNLDGQLISDMERDDLHREVLRTQGTLTSCFGYDAMGRKAWQFASTLPAEKLSQILNPGIQPELLVEHAYNPIHRRHQYDPAGELTRTLDKLRGEIKYDYEANGQLRSRDTGKLVDSEEFRYDAAANRLNFNTSQFDHVKNNRIKQWRDQEYAYDAWGNLIEKRSGLSRLQTFSYDGENRLVKAETLVNGKLESSGAYRYDSLGRRVAKVSAVNGVTEQKHFLWQGLRLLREETPGQSSLYLYEPGSYAPLARVDQVEGGEQQLYYFHTDQIGTPLEMTDREGRIVWQATYKAWGSVEKLEVNEVEQNLRFQGQYFDDETGLHYNTFRYYDPEVGRFITQDPIGLLGGGNLYFYVPNSMGWIDPQGLSSADLRVELGMRPGDMHAAHHIIPEEVMKKYPQMFDKAKTFGFMPDGASNGIELPRTKDLAKTLDLPGHWSNHVDYTALVESDVSKLNTAFRAGRLTDMDLALGLKSIQNKWRSNILAKNVPTNAKGRLC
>NZ_CP014870|2473630:2519090|2504847_2505444_+|WP_064677249.1|DBSCAN-SWA
MKNLYIVSYEPDGEGAPYFFDFKWIPELPEFHYPTENPESGELIAKYRAVADVPQLNADWLPDHFLASEKFLAICDFCECSYVSRPVEILIEGKLAPNKKYHFFAATERLRAMDLEKSSFVLDSNLKIEVTDSKNQNYERIDKLVISSGINSNFFYFEEIHEVVCSEQFLIECVNRQIYGLAFKKIDGDYRYAPWDDF
>NZ_CP014870|2473630:2519090|2490007_2491498_-|WP_064677242.1|DBSCAN-SWA
MDLLANVPSWADVERNLDQKFSELNQGVNEGLQSVHDNWNGFTRRVGNGASQAYGYMGGHRIDAVNRAMTLSYPIIQMDLKRKWASIEIEQILPVLLQLVKEVSMILGGSVAIGTVAGGAAGAFAFGIGAAPGAAAGAGIGLQVGNLILMGLGLSAIAEYFYQGLPACLSSLQEGIATAWHAEEGVKPSGLDPTGGSAALVQERIERSARQLARGQEQLVLLLLTAIVTYLTRGQMKAGVVGSMESIATRSAKLQAQISNKQLAGWLARNEQKLLAQAELHVKEPAPLAKVELPEVKKITERPVEAKRPPAPPPLMSLRDAVGQQTAERWIANGRKIADKADPDRSRLLTDDQIGALHGYTTNEGYTWINPALRGKTPITEQMEAFATHAKDGLAKLPRYVEGETYRGTSLPADVLTEIRMGHPTSDGAFFSTSAETGKAFSGNVRIVTRGTSGRDISFLSGHREAEVLYPPGTQFNVLNKIESGSVTHLLYQEIP
>NZ_CP014870|2473630:2519090|2478348_2479419_-|WP_064677233.1|plate|DBSCAN-SWA
MATANRRSTPGLIDQARAEPHRFEFFQLVRLLRLHYSRTGRMDLDTRPHEDPLRFRSQLSLNFPASEVSDLQFEREGKVSAAGLPLSEVQVTFMGLVGPSGVLPRPYTELLIERHIQYRDDAAHAFLDIFSHRMTTLFYEAWQKYKFYIEYERNGTSDFDRYLLNLVGFGPEAQKQKFDRQGSPLRRELFSYFSGLFAQKPRNAMNLEAMLGFYFSLPFKVKPFAGRWLKLDAGQCTQLGRKNAVLGQSAVAGNRVWDYQSCVRIEIGPLDLVDYQRFQPGTVDYQKLVELVRFYVGAELDFQLAPRLKPAAVPVARLGRQGNVSLGWLGWLKRPGVDVEPSRCALFHIPFDGVSL
>NZ_CP014870|2473630:2519090|2501840_2502317_+|WP_082930299.1|DBSCAN-SWA
MVTVNSETAKEIINSEAYRTLVAELKSHLRISVIESYEDVFARLDAASIIRSELEVDEIKSLFGLRSNELKRYSIKKYTALHGNPDEQEYPVGEEPSTEDKDSNIVSQGYAPGFLLINAIELLLSCKGVDSLNKYLKASRIPKAHSYSKQVIKFSNMN
>NZ_CP014870|2473630:2519090|2473630_2474974_-|WP_064677230.1|plate|DBSCAN-SWA
MSKQSRVMWSEGMFLLPQHFQYQDEFHQHQLAESTLRSTPFHWGVQMLQVDEEALATGSLQLKRLKLVFPDGSLYDAPQHDPLPAARDLKDLLKGNDLKVYAALKLPEPFGMNYIEDGQEQRSARRFRKQFDTLPDLNEGDLENEITSLRLNVVMLIDGDNLDGYSWCPIARLSRNNIGGFNLDAHFVHPTLHVGTHETLIGLGKRLLGALQSKSKALSGRRRERADQIAEFGSSDVTLFWLLNTVNRAHPGLAHLLAHPRLHPERLYLFLAELAGGLLTFSLDTQLNDIPEYDHHDPAASLVKLDEMIRVLLDNVVPNQCVVINLTQTKPSYWQGQLLDPRLAEADFYISVHADMPGSSLLELVPRAFKVGSPEDIEVVVNSAMPGVTLNHASRLPNAIPVRLDNHYFSIEPHGRVYERMMSAQAISFYAPSAFTNLKLELMAVLK
>NZ_CP014870|2473630:2519090|2514063_2514768_-|WP_064677256.1|DBSCAN-SWA
MCGRLSQYRGIHDFVAALAIPNALINYVGDQPLARYNAAPTTQLALFHQEGQFLRADLVRWGWRPHWAKDRAAPINARVEKVAHGPFFKAIWPRRAIIAIDNWFEWVDEGGPKKQPYLIRHRDRTPILCAAIGQYPNAEHEPGEHDGFVIITADSAGGMVDIHDRRPVTLSPELAREWLEPATPMERAEHMALFQGKPTEAFEWFKVDRAIGNVRNQSAQVIDPAGEIEGDGYT
>NZ_CP014870|2473630:2519090|2488425_2488689_-|WP_064677240.1|DBSCAN-SWA
MKLQDIYVNREELFSLGIEKTSGRFYASFPVSNGMVDYEEYYEIDRASFELFQKNIDAAVDFVMKCRRRELDELLIEKPGTNRGSAV
>NZ_CP014870|2473630:2519090|2499389_2500013_+|WP_064677247.1|DBSCAN-SWA
MYIIGYKGGEDGCPENSIYGELVGYNWNSNDFADKKFPSVGTILDFYAQHRIVDSDFFYFGSEFICSEFLLRLIIDSSFGSVDIRDVRLHQQNKAFPLASKKYYLLRSREVHKILDMAKSTYEFRFDPVTKTPEEDAYHSGRLIFDLISDFQLSENLCPLDIFVASEMLKDEYVISDALAERITECRLKGVNLTPLSKYIYDAKLEF
>NZ_CP014870|2473630:2519090|2516807_2519090_+|WP_064677258.1|tail|DBSCAN-SWA
MPVQLSYPGVYIEELPSGVRTITGVATSVAAFAGSAPRGPINNAQHLFSFADYERRFGGLAVDSEMGYAVRQFFQNGGTEAYVVRIVKDASTASKTLQNATPIDVLKVQALDEGAAGNGIEVRVDHLTINPGSSFNITFIRASDGRAERYENLSMNSMDARYALDQVNAVSQLVKLSRMVGQSALDGLAAGTSRSANLADVTTLLDANHNEFRVSVNNLPPVKVLIALPADIAGGTATQRLDSLCGAIQTKVRAQANSQLAYQNFTCGRPATTQTILMTSGVGGEFSSVRVLPGQKSNASAALKLGSEAGGVEVDAVGAIRPVPVPDPATLTSDTFGANDLDALPDATHTGLRISLDGNSDVIDIGDALAVGGNLADKLSDMAARIQAAVRARKPGDPAYRNFTCAVAGSTLVLATGTRGAASSIAVSASPLNSIASQLHLLAGSLTTQPVNVTLQGGSETAYAAADIYAAFIADRDTRKGLYALEAVDLFNILCLPGITDAGVLMDAAAYCEERRAFFVIDSPPMAVDPQQMVATVSGTALPKSDHAAVYYPWIYIADPLKNGKLRLSAPCGTVAGLYARTDGDRGVWKAPAGTEASLIGVQALNYQLNDRENGSLNPLGVNCLRSFPVYGAVSWGARTLRGADQMTSEYKYVPVRRLALFLEESLYRGTQWVVFEPNDEPLWAQIRLNLGAFMNSLFRQGAFQGKTPREAYLVKCDRETTTQDDINRGVVNILVAFAPLKPAEFVVIRIQQLAGQIQV
>NZ_CP014870|2473630:2519090|2507323_2508691_-|WP_064677251.1|DBSCAN-SWA
MQLKHKIVALGILPLVLAIAVICALVISLNRQLGDQQAQLIEDSILASKRAELKNYVEMAQSLIEPLYDDGHGDARAQQQVLEELRKLSFGVNGYFFVYDREGRSLMHARQSDLVGKDLWDMKDPHGLPVIQALLNTAQSGEGFQRYAWNKPSSGQVTDKLAYVVMLDRWGWMLGTGIYLEDVERATQQARDEVAMGIRKTMLAIAAVALVAVLLVFASGMTLNVSEHRLADKKLQRLTQRIVSLQEEERSRVSRELHDGISQVLVSIKFQFELASHVLENDQGRDKGLGILREATQRLGDAIGEVRSLSHDLRSSLLDTLGLPAAIGQLAAEFEQRSGLVVTYDDNEFACDLVDGAAVSLFRIVQEGLTNIERHARARNVSITLHGSEDGVRLTVVDDGIGFNVAKVERRHAGIGLRNIRERVEHFGGQFALTSTPGRSELDVLLPMQMPGTQR
>NZ_CP014870|2473630:2519090|2514893_2516225_-|WP_064677257.1|DBSCAN-SWA
MTSAAQVSPQTLRKVIVAAGIGNFVEWFDFAVYGFLATTIAQQFFPSGDASVALLKTFAVFAVAFAFRPLGGIFFGMLGDRIGRKRTLAMTILLMAGATTLIGVLPTYAAIGVMAPILLTVIRCAQGFSAGGEYAGACAYLMEHAPNDKRAWYGSFIPVSTFSAFAAAAVVAYALEASLSAEAMGSWGWRLPFLIAAPLGLVGLYLRWKLDETPAFQAVTEEHAVAHSPLKETLRNHGAAICCLGAFVSLTALSFYMFTTYFATYLQVAGGLSRATALLVSLIALIFAAAICPLAGLYSDRVGRRATVMTACALLIVVVYPSFLMASSGSFAASIVGVMLLAIGAVLCGVVTAALLSETFPTRTRYTASAITYNMAYTLFGGTAPLVATWLISTTGSNLSPAFYLMAVALLALAGGLALPETSRISLHDVPMRKGGVAVDAAA
>NZ_CP014870|2473630:2519090|2481722_2483225_-|WP_064677236.1|DBSCAN-SWA
MNDKQTVTQQDSDLVEVENFAPPSSLLDSIISQSRVARSETERTRTRDLIGELVSQVLEGEMTPSKDLIAVLDARIAEIDAMLSEQMNEIMHAREFQQLEASWRGLKYQVDQTETSTTLKIQLLNASKKDLVRDLKSASEFDQSALFKKIYEEEYGTFGGAPFGMLLGDYEFNRSPEDMYLLEEISHVAAAAHAPFISAASPELFGWDSFTDMSGPRDLAKIFDTVEYAKWKSFRASEDSRYVGLTLPHVLGRLPYGPDTTPVEEFNFVESVDGRDHNKYLWMNAAYALGTRVTDAFSRYGWCVAIRGVEGGGLVEGLPTHTFKTDDGEIALKCPTEIAITDRREKELSDLGFIPLVHCKGTDYAAFFGTQSTQKQKHYNTDIANANARLSAQLQYIFATSRIAHYMKAIMRDKIGSFASRKDVELFLNKWLSSYVLLDDTASQEAKAKFPLREARAEVFEVPGKPGVYKAVTYLRPHYQLDELTASLRLVAELPQSTRG
>NZ_CP014870|2473630:2519090|2481214_2481697_-|WP_064677235.1|plate|DBSCAN-SWA
MSSQHRLLPSLLDRLLDDLPHQSMEASSQRLCSLADYKASIVRDLEVLVNTRQSLVANELEGFANLGGTILDYGMPDFTSRSVLDPQDRLLIQRQLEKAISVGDRRFRNVKVQLLAQQTGQRMLTFRVDAVLRLQDITRQVSFDAVLQVNTQEYKVQNLN
>NZ_CP014870|2473630:2519090|2492197_2494048_+|WP_064677243.1|DBSCAN-SWA
MLMDLAAMLSPQNRRLFKFTNLANPDQQLLLESFKGTDGLSRAYNFELMLVCQDSGVELKSMMGQHVVLEIELAEAGPRYMAGYLTRFASIGSDGGMARYTATLNPWFSMLKNRFDTRIFQGCTVEEVVTQVFALCSAFSRHEFRLSKPLKRYTYITQYRETDFNFVQRLLEEEGMFYYFEHTADTHTMIICDDSSTLLPLPEQPQIRFHTASVTETADSITQWSGNRQLQSGKIAVQTFDYRQPTNRLPVAMKSLNKQGDVDDFEIYDFPGQYTHGTYDEGEALVRLRVEALELKGKSFHGASNCRAMKPGYTFELLQHYDHDQGSADDRQFLLMSVESEGHNNYLNGHQASYYNTFSCVRKKIVFRPQLTTPRPTISGPQTAIVVGPPGEEIFTDELGRVKVQFHWDRKGEHNDKSSCWVRVAQSGASGGFGSILIPRVGDEVVVVFLDGNPDRPLIMGSLYNSKNTPPWSLPANKTQSGFLTRSMKGDGGTANFFRFEDKAGAEQVIMHAERNMDTEIEVDETHSVGSNRTITVGGTHTETIKKDTVMNVQEGSLTIQVDNQFIQVNAKEHIILQVGDSSITLTPAGIEIKGDVINILGKNTYVQGDRVDINK
>NZ_CP014870|2473630:2519090|2512547_2513288_-|WP_064677255.1|DBSCAN-SWA
MFETREVRRFAANPVGRDLAVGDIHGHFARLQTALDAAGFNPSIDRLFSVGDLVDRGPQTLDVDEWLLHKPWFHAVRGNHEQMTVKSHAAGRASVERGLHFANGGAWFYGLSGTEQAYYAGILAELPLVIEVQTPQGLIGIVHADVPPGSWQDMTEALSGLAMEVEQIATTLQWSRRRITDSDPGGVSGVRAVVVGHTPLPQPVILGNVYHIDTGGWLPERGHFTLLNLQTLEFIPPMRPGLSRHW

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064677230.1|2473630_2474974_-|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_082930297.1|2474966_2475725_-	type VI secretion system lipoprotein TssJ	NA	NA	NA	NA
WP_064677232.1|2475748_2478352_-	type VI secretion system ATPase TssH	A0A223W0B1	Agrobacterium_phage	3.6e-92	30.7
WP_064677233.1|2478348_2479419_-|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_064677234.1|2479382_2481215_-|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_064677235.1|2481214_2481697_-|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA
WP_064677236.1|2481722_2483225_-	type VI secretion system contractile sheath large subunit	NA	NA	NA	NA
WP_064677237.1|2483235_2483769_-	type VI secretion system contractile sheath small subunit	NA	NA	NA	NA
WP_064677238.1|2483839_2484589_-	hypothetical protein	NA	NA	NA	NA
WP_082930298.1|2485234_2486932_+|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_082930469.1|2487071_2487356_-	hypothetical protein	NA	NA	NA	NA
WP_161491163.1|2487457_2487970_-	hypothetical protein	NA	NA	NA	NA
WP_064677240.1|2488425_2488689_-	hypothetical protein	NA	NA	NA	NA
WP_064677241.1|2488895_2490011_-	ADP-ribosylglycohydrolase family protein	A0A1S6UB21	Serratia_phage	7.0e-61	46.0
WP_064677242.1|2490007_2491498_-	hypothetical protein	NA	NA	NA	NA
WP_064677243.1|2492197_2494048_+	type VI secretion system tip protein VgrG	A0A077K8Q4	Ralstonia_phage	2.5e-63	29.6
WP_064677244.1|2494059_2494644_+	hypothetical protein	NA	NA	NA	NA
WP_064677245.1|2494681_2495143_+	DUF1795 domain-containing protein	NA	NA	NA	NA
WP_064677246.1|2495146_2499373_+	RHS domain-containing protein	A0A2H4JFP5	uncultured_Caudovirales_phage	3.6e-33	51.9
WP_064677247.1|2499389_2500013_+	hypothetical protein	NA	NA	NA	NA
WP_082930299.1|2501840_2502317_+	hypothetical protein	NA	NA	NA	NA
WP_064677249.1|2504847_2505444_+	hypothetical protein	NA	NA	NA	NA
WP_082930300.1|2505523_2506351_+	RHS repeat protein	NA	NA	NA	NA
WP_064677250.1|2506659_2507292_-	response regulator transcription factor	NA	NA	NA	NA
WP_064677251.1|2507323_2508691_-	cache domain-containing protein	NA	NA	NA	NA
WP_064677252.1|2509206_2511264_+	carbon starvation protein A	NA	NA	NA	NA
WP_064677253.1|2511278_2511476_+	YbdD/YjiX family protein	NA	NA	NA	NA
WP_064677254.1|2511838_2512495_+	trypsin-like peptidase domain-containing protein	NA	NA	NA	NA
WP_064677255.1|2512547_2513288_-	metallophosphoesterase	A0A2H4J0P0	uncultured_Caudovirales_phage	1.4e-70	53.7
WP_082930470.1|2513438_2513639_-	hypothetical protein	NA	NA	NA	NA
WP_064677256.1|2514063_2514768_-	SOS response-associated peptidase family protein	A0A2H4J991	uncultured_Caudovirales_phage	1.7e-105	77.0
WP_064677257.1|2514893_2516225_-	MFS transporter	NA	NA	NA	NA
WP_064677258.1|2516807_2519090_+|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	5.5e-12	28.3

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NZ_CP014870|4406198:4412473|DBSCAN-SWA
CATGAAGTTCGCCATCGCGCTGTTTTCCGCCGCCCATGCGCCCTCCTCGCGCCGCGCCTTGCTGTTCGCCCAGGCCGCGCTGGCCGGCGGGCATGAGATTGTCCGGCTGTTTTTCTACCAGGACGGCGTTCATAACGCCTCCGGTAGCGTGGTCACCCCGCAGGATGAGCTGGATTTGCCCAGGCAATGGCGCACCTTCGTCACCGAACATCAACTGGACGGCGTCGTCTGTATCGCCGCCGCCCTGCGCCGTGGCGTGTTGAACGCAGAAGAAGCCGGGCGCTACCAGCGCGAAGCGGTCGCCGTAGCCGCGCCGTGGGAGTTGTCCGGGCTGGGCCAGTTGCACGACGCGGTGCAGGACGCTGACCGCCTGATCTGTTTCGGAGGCGCGTGAAAATGCCCAGATCCTTGCTGATTATCAGCCGTCAGTCCCCCTGGTCCGGGCCGAGTGCGCGCGAAGCGCTGGACGTCGTGCTGGCCGGTGGCGCTTTTGATTTGCCTGTGGGCCTGCTGTTCCTCGATGATGGCGTGTTCCAGCTCGCCGCGAAGCAAGACGCCAGGGCCTTGCAACAGAAAGACCTGAGCGCCAACCTGCAGGCGCTGCCGATGTTCGGGGTCGACGACCTGTTCGTCTGTGGCGGCAGCGCTGCCGAGCGCGGCCTGGACCCGAAGGTTTTGTCGCTCGAAGCAGCCCAGGTGCTGAGCGCTGGCGAAATCACCGCGCTTATCGACCGTTACGACCAGGTGATCACCCTCTGATGTCGACTTTACATGTGTTGTCCCATTCCCCTTTCGGCGACGATCGCCTGACCAGCTGCCTGCGCGTGATCGGCGCCGAGGATGCGCTGCTGCTGTCTGGCGACGCGGCCTATGCCTTGCAACCGGGTACCGCCCCGTTCAATACCCTGGGCACCCGCGGCCTGAAACTGTTTGTGCTGGCTGAAGACGCCCAGGCTCGCGACCTGCAAACGCCGGACTGGGCGAAGGCCATCGACTACCCGGCCTTCGTTGAGCTGTCGATCCGCTACGACAAGGTCAACAGTTGGCTATGAACGTCCTGAACGTCGGCGCCCGCGCCATCGAGCTGGACAAGGACGGTTTCCTGCTCGAACTGGGCGACTGGTCCTCTGAGGTCGCCAGCGCCCTCGCCGCCGCCGAAGACATCGAGTTGAGTCCCGAACACTGGGAGATCCTCGAGTTGCTGCGCAGTTTCTACAGCGAATTCCAACTGTCCCCGGCCACGCGTCCGCTGATCAAGTACACCGCATTGAAACTCGGCCCGGACAAAGGCAACAGCCTGCACCTGAACCGACTGTTCAAAGGCACCCCTGCCAAACTCGCCGCGAAACTGGCGGGCCTGCCCAAACCGACGAATTGCCTATGACCGACTACCCTGCGCTGACCCTTGAAACTCCCGCCGAGCACCCTTTCGCCCAGTTCGTGCGCATCCTCGGCAAAGGCAAACGCGGCGCCCGCGACCTGACTCGGGTCGAAGCGCGTGAAGCCATGGGCATGGTGCTCGACGACAAGGTCGAGGACACCCAGCTCGGCGCTTTCCTGATGCTGCTGCGGCACAAGGAAGAAAGCGCCGAAGAGATGGCGGGGTTCACCGAAGCCTTGCGTGAGCGCTTGCAGGCACCGGCATTGAATGTCGATCTGGACTGGCCGACCTATGCCGGCAAGAAACGCCATCTGCCGTGGTACCTGCTGGCGGCCAAGTGCCTGGCGCAGAACGGCGTGCGGATCTTCATGCACGGTGGCGGCGCGCACACGGCGGGACGGCTGTACAGCGAGCAACTGCTGGATGACTTGAATATTCCTTTGTGCCGCAACTGGCAGCAGGTCGGCACGGCACTGGATCAGGGCAGCCTGGCGTTCATGCCGCTGACGGACTGGGCGCCGCAATTGCAGCGGATGATCGATCTGCGCAACACCCTGGGCCTGCGTTCGCCGATCCATTCCCTGGCTCGGATCCTCAATCCATTGGGCGCTCGCTGTGGCCTGCAGAGCATTTTTCACCCCGGTTACCAGGCCGTGCATCGCGACGCCAGCGGCTTGCTCGGCGACACCGCGATCGTGGTAAAAGGCGACGGCGGCGAGATCGAGATCAACCCGGACGCCGACAGCCATTTGTACGGCACCACCGGTGGCGAGAGCTGGGACGAAGAATGGCCGCAACGTTCAGCCCAGCGCCACGTCAAACCGGCCAGCCTCGATCCCGAGCATCTGAAAGCCGTCTGGCGCGGCGACGTGGTCGACAGCTATCCGCAGATGGCGCTCATTTCGACCATGGCCCTCGCTCTGCGCGGCCTCGGCCAGAGCCGTGAACAAGCCTTCGACACCGCCCAGCAGTATTGGGACGCGCGGGACAGATCGATTTAACCGATCATAACCGCCCAACCTTTGCGCTATTTGTTCGAACCTATGGGAATAGACTCCTCTCCAACGCTTATCGGTCGAGGAGTCTTGAAATGGGTTTGTTAGTCGAAGGCCGCTGGCACGACCAGTGGTACGAAAGCAGCAAGGACGGCGCGTTCCAGCGTGAACAGGCGCAGCGCCGCAACTGGGTGACCGCCGACGGCAAGCCAGGTCCGAGCGGTGTCGCAGGCTTTGCAGCCGAAGCCGGTCGGTATCATCTTTATGTGTCCCTCGCCTGTCCGTGGGCCCATCGCACGCTGATCCTGCGCAAACTCAAAGGCCTGGAAAGCCTGATCGATGTGTCCGTGGTCAGCTGGCTCATGCTGGAAAACGGCTGGACCTTCGATCAAAACCTGGGCTCGACGGGCGACAAGCTCGATCACTTCCAGTTCATGCACCAGCGTTATACCGCCGATACCGCCGACTACACCGGCCGCGTCACCGTGCCGGTGCTCTGGGACAAACAACAGAACCGCATCGTCAACAATGAATCGGCGGAGATCATCCGCATGTTCAACAGCGCTTTCGATGACTTGACCGGCAATGATCTGGACCTTTATCCGGCGCCGTTGCGCGGCGAGATCGATGCATTGAACGAGCGGATTTATCCGGCCGTGAACAATGGCGTGTATCGCGCCGGATTCGCCACCTCGCAGAAGGCTTATGAAGAAGCGTTCGATGAGTTGTTTGCCGAGCTGGATCGGCTGGAGCAGTTACTGGGCGCCAATCGTTATCTGACGGGCGAGTACCTGACTGAAGCCGACATTCGACTGTTTACCACGATGATTCGCTTCGACGCGGTGTATTACGGGCACTTCAAGTGCAATCTGCGGCGGATAGCGGACTATCCGAATCTATCGAACTGGCTGCGGGAGATTTATCAGTGGCCGGGGATTGCTGAAACGGTGAGTTTTGAGCATATCAAGCACCACTACTACGGCAGTCACAAGACCATCAATCCGACGGGGATTGTGCCTAAGGGGCCGGTGCAGGATTTCACGGCGCCGCATGATCGGGGGCGGTTGAGCGGGAAAGGGGTTTGGCGCAAAGCTGCGGTCTGATCTGAAGTATGGGGTGGTTTTGAGGCCCTCTTCGCGAGCAAGCCCGCTCCCACATTGGATTTGTGGACGACGCAAATCCAATGTGGGAGCGGGCTTGCTCGCGAAGGGGGCCACTCGGTCTCTAGAGTTGCCCCTGAGCCCCTTCAAACCACGCCAGTTTCTCGCGCAATTGCACCACCTCCCCAACAATCACCAATGTCGGCGCATGCACTTCATGCTCCGCCACCAGCTGCGGAAGGTCGGCCAAGGTGCCGGTAAACACCCGCTGATTGACCGTGGTGCCCTGCTGAATCAACGCCGCTGGGGTATCCGCCGCGCGGCCGTGCTTGATCAACTGCTCACAGATGATCGGCAACCCCACCAACCCCATGTAAAACACCAGGGTTTGCGCCGGCGCGACCAGGTCGGCCCACGGCAGATCGGTGGAGCCGTCCTTGAGGTGCCCGGTGACGAACCGCACCGACTGCGCGTAATCGCGGTGGGTCAGCGGGATCCCGGCATAGGCCGCGCAACCGCTGGCGGCCGTGATCCCCGGCACGACCTGGAACGGGATGCCATGGGCCGCCAGTTCTTCGATCTCTTCGCCGCCACGGCCGAAGATAAACGGATCGCCACCCTTCAGGCGCACCACGCGCTTACCGGCCTTGGCCAGGTCCACCAGGCGCTGGTTGATCTGATCCTGGGGCACGGCGTGCTCGGCGCGGCGTTTGCCGACGTAGACCCGCTCGGCATCGCGACGGCACAAATCGAGAATCGCCGGCGCCACCAGGCGGTCATACAACACCACATCGGCTTGCTGCATCAGCCGCAAGGCGCGGAACGTCAGCAGGTCGGGATCACCCGGGCCGGCGCCAACCAGATAGACTTCGCCCGTTGCATCCGGTGCTTCACCGGCAATTTTCGCCAGCATCAGGCGCTCGGCTTCGGCGCCCTGCCCGGCCAGTTGCCGGTCGGCAATCGGGCCCTGGAACACATCTTCCCAGAATGCCCGACGCTGCTGCACATCCGGGAACAGGCGTTTGACCTGGCCGCGGAAACGCGCCGCCAGACCGGCCAGTTGCCCGTAGGTGGACGGAATCCAGGTTTCCAGTTTGGCCCGGATCAACCGTGCCAGCACCGGCGCATCGCCGCCGCTGGAGACCGCGATGATCAGCGGCGAACGGTCGACGATCGCCGGGAAGATCACGCTGCACAGGGCTGGCGCATCCACCACGTTGACCGGCACGCAACGCCGATGGGCATCGGCGGAGACTTGTGCATTGAGCGGTTCGTCGTCGGTGGCGGCAATGATCAGCCCGCAACCGTCCAGATCGGCCTCGACGTAACCGCGCACCAGGCACTCGCCACCGCTGCCGGTCACCAGTTCCCGCAGTTGCGGTTCGATGTCCGGTGCGACCACCCGCAGCAGTGCACCGGCTTCGGCCAGCAGGCGGGATTTGCGCAAGGCAATTTCCCCGCCGCCGACGACCAATACACGACTGCCGCGAAGGTTATGAAACAGCGGCAGATAGTCCATTTAGCCGATGACCTCGATGCCACCCATGTACGGTTTCAGCACGTCTGGCACACGGATCGATCCGTCGGCCTGCTGGTAGTTTTCCAGCACCGCCACCAGGGTACGCCCGACCGCCAGGCCGGAACCGTTGAGGGTGTGAACCAGCTCGGGCTTGCCGGTTTCCGGGTTACGGAAACGCGCCTGCATCCGACGGGCCTGGAAGTCGCCGCAGTTGGAGCACGAGGAAATTTCGCGGTACTTGTCCTGGCTCGGGATCCACACTTCCAGGTCGTAGGTCTTGACGGCGCTGAAGCCCATGTCGCCGGTGCACAGCGCCAGGGTGCGGTATGGCAGTTCCAGCAGTTGCAGGACTTTCTCGGCGTTGGCGGTCAGGCCTTCCAGCGCTTCCATCGAAGTCGACGGCTCGACGATCTGCACCATCTCGACCTTGTCGAACTGGTGCTGGCGGATCATGCCGCGGGTGTCACGCCCCGAGGCACCGGCTTCACTGCGGAAGCACGGCGTGTGCGCCACGAACTTGATCGGCAGCAGCTTCGAATCGACGATTTCGCCGGCGACGATGTTGGTCAGCGACACTTCGGCAGTCGGGATCAGGTACAGGTCGGCTTCGCCTTCGCGAGCGATCTTGAACAGGTCTTCTTCGAACTTCGGCAGCTGACCGGTGCCTTGCAGCGCCGGCGCCTGGACCAGGTAAGGCGTATAGGCCTCTTCGTAGCCGTGTTCGCTGGTGTGCAGGTTGATCATGAACTGCGCCAGGGCGCGGTGCAGACGGGCGATCGGGCCGCGCAGCAGGGCGAAACGCGCGCCGGACAGCTTGGCGGCGGTTTCGAAATCCAGCCAGCCGAATTTCTCGCCCAGGGCTACGTGGTCCTGAACCGGGAAATCGAACGCCGTCGGCGTGCCCCAGCGGCGCACTTCAACGTTGCCTTCTTCGTCGTCGCCGATCGGCACCGATTCGTGCGGCAGGTTGGGGATGCCCAGCAGGATCGAGTCCAGATCGGTCTGGATCGCGTCCAGCTCGACTTTACCGGCGCTCAATTCGTTCGCCATGCGCTCGACATCCGCCATCAGCGGCGCGATGTCTTCACCGCGTTGCTTGGCCTGGCCAATGGATTTGGAACGCGCATTACGCTCAGCCTGCAGTGCTTCGGTGCGGGTCTGGACGGTCTTGCGCTGTTCTTCCAGCGCTTCGATGCGCGCAACATCCAGCTTATAGCCGCGGGATGCCAGGCGGTCCGCTACGTCCTGAAGGTTGCTACGTAACAGTTTGGAATCGAGCAT

Protein sequences of DBSCAN-SWA_2

>NZ_CP014870|4406198:4412473|4411192_4412473_-|WP_064678725.1|tRNA|DBSCAN-SWA
MLDSKLLRSNLQDVADRLASRGYKLDVARIEALEEQRKTVQTRTEALQAERNARSKSIGQAKQRGEDIAPLMADVERMANELSAGKVELDAIQTDLDSILLGIPNLPHESVPIGDDEEGNVEVRRWGTPTAFDFPVQDHVALGEKFGWLDFETAAKLSGARFALLRGPIARLHRALAQFMINLHTSEHGYEEAYTPYLVQAPALQGTGQLPKFEEDLFKIAREGEADLYLIPTAEVSLTNIVAGEIVDSKLLPIKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVEPSTSMEALEGLTANAEKVLQLLELPYRTLALCTGDMGFSAVKTYDLEVWIPSQDKYREISSCSNCGDFQARRMQARFRNPETGKPELVHTLNGSGLAVGRTLVAVLENYQQADGSIRVPDVLKPYMGGIEVIG
>NZ_CP014870|4406198:4412473|4407245_4407581_+|WP_064678721.1|DBSCAN-SWA
MNVLNVGARAIELDKDGFLLELGDWSSEVASALAAAEDIELSPEHWEILELLRSFYSEFQLSPATRPLIKYTALKLGPDKGNSLHLNRLFKGTPAKLAAKLAGLPKPTNCL
>NZ_CP014870|4406198:4412473|4407577_4408579_+|WP_064678722.1|DBSCAN-SWA
MTDYPALTLETPAEHPFAQFVRILGKGKRGARDLTRVEAREAMGMVLDDKVEDTQLGAFLMLLRHKEESAEEMAGFTEALRERLQAPALNVDLDWPTYAGKKRHLPWYLLAAKCLAQNGVRIFMHGGGAHTAGRLYSEQLLDDLNIPLCRNWQQVGTALDQGSLAFMPLTDWAPQLQRMIDLRNTLGLRSPIHSLARILNPLGARCGLQSIFHPGYQAVHRDASGLLGDTAIVVKGDGGEIEINPDADSHLYGTTGGESWDEEWPQRSAQRHVKPASLDPEHLKAVWRGDVVDSYPQMALISTMALALRGLGQSREQAFDTAQQYWDARDRSI
>NZ_CP014870|4406198:4412473|4406955_4407249_+|WP_064678720.1|DBSCAN-SWA
MSTLHVLSHSPFGDDRLTSCLRVIGAEDALLLSGDAAYALQPGTAPFNTLGTRGLKLFVLAEDAQARDLQTPDWAKAIDYPAFVELSIRYDKVNSWL
>NZ_CP014870|4406198:4412473|4408668_4409676_+|WP_064678723.1|DBSCAN-SWA
MGLLVEGRWHDQWYESSKDGAFQREQAQRRNWVTADGKPGPSGVAGFAAEAGRYHLYVSLACPWAHRTLILRKLKGLESLIDVSVVSWLMLENGWTFDQNLGSTGDKLDHFQFMHQRYTADTADYTGRVTVPVLWDKQQNRIVNNESAEIIRMFNSAFDDLTGNDLDLYPAPLRGEIDALNERIYPAVNNGVYRAGFATSQKAYEEAFDELFAELDRLEQLLGANRYLTGEYLTEADIRLFTTMIRFDAVYYGHFKCNLRRIADYPNLSNWLREIYQWPGIAETVSFEHIKHHYYGSHKTINPTGIVPKGPVQDFTAPHDRGRLSGKGVWRKAAV
>NZ_CP014870|4406198:4412473|4406198_4406591_+|WP_064680765.1|DBSCAN-SWA
MKFAIALFSAAHAPSSRRALLFAQAALAGGHEIVRLFFYQDGVHNASGSVVTPQDELDLPRQWRTFVTEHQLDGVVCIAAALRRGVLNAEEAGRYQREAVAVAAPWELSGLGQLHDAVQDADRLICFGGA
>NZ_CP014870|4406198:4412473|4406593_4406956_+|WP_064678719.1|DBSCAN-SWA
MPRSLLIISRQSPWSGPSAREALDVVLAGGAFDLPVGLLFLDDGVFQLAAKQDARALQQKDLSANLQALPMFGVDDLFVCGGSAAERGLDPKVLSLEAAQVLSAGEITALIDRYDQVITL
>NZ_CP014870|4406198:4412473|4409797_4411192_-|WP_064678724.1|DBSCAN-SWA
MDYLPLFHNLRGSRVLVVGGGEIALRKSRLLAEAGALLRVVAPDIEPQLRELVTGSGGECLVRGYVEADLDGCGLIIAATDDEPLNAQVSADAHRRCVPVNVVDAPALCSVIFPAIVDRSPLIIAVSSGGDAPVLARLIRAKLETWIPSTYGQLAGLAARFRGQVKRLFPDVQQRRAFWEDVFQGPIADRQLAGQGAEAERLMLAKIAGEAPDATGEVYLVGAGPGDPDLLTFRALRLMQQADVVLYDRLVAPAILDLCRRDAERVYVGKRRAEHAVPQDQINQRLVDLAKAGKRVVRLKGGDPFIFGRGGEEIEELAAHGIPFQVVPGITAASGCAAYAGIPLTHRDYAQSVRFVTGHLKDGSTDLPWADLVAPAQTLVFYMGLVGLPIICEQLIKHGRAADTPAALIQQGTTVNQRVFTGTLADLPQLVAEHEVHAPTLVIVGEVVQLREKLAWFEGAQGQL

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064680765.1|4406198_4406591_+	sulfurtransferase complex subunit TusD	A0A2H4JA39	uncultured_Caudovirales_phage	1.1e-53	79.8
WP_064678719.1|4406593_4406956_+	sulfurtransferase complex subunit TusC	A0A2H4J8C0	uncultured_Caudovirales_phage	8.4e-40	67.5
WP_064678720.1|4406955_4407249_+	sulfurtransferase complex subunit TusB	A0A2H4JG28	uncultured_Caudovirales_phage	5.2e-32	68.7
WP_064678721.1|4407245_4407581_+	TusE/DsrC/DsvC family sulfur relay protein	A0A2H4J8B6	uncultured_Caudovirales_phage	2.7e-45	81.1
WP_064678722.1|4407577_4408579_+	glycosyl transferase family protein	A0A2H4JBY5	uncultured_Caudovirales_phage	1.6e-165	85.7
WP_064678723.1|4408668_4409676_+	glutathione S-transferase family protein	NA	NA	NA	NA
WP_064678724.1|4409797_4411192_-	uroporphyrinogen-III C-methyltransferase	NA	NA	NA	NA
WP_064678725.1|4411192_4412473_-|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	4.8e-98	53.6

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NZ_CP014870|4746553:4754157|DBSCAN-SWA
TTCATGTCATATCTGACTGAAAACTATTGCAAGCAGCCACCACCGCACGTGCTTCTTCCAAAAGCAAGCCAGGCCCCATCGGCAAACTCAATATTTCGCGATGGATTTTTTCCGATACCGGCAATGAATATCTCGCAAGCTCCGAATAAGCCTGTTGCTGGTGAGGGGGTATGGGGTAATGAATGAGTGTTTGTATATTGTTCGCAAGCAGATGGTTCTGCAGCGCGTCCCTATCTTGACAAAGTACGGTATAAACGTGCCAGACATGACTTGAATTTTCTAAAGGATTGAACTGCGAAACAACAGGTAAAGTGATTGCAGGGTGTTGGATATTATTTGTGTACAGGTCTGCAATCTTTCGCCTATGGATAGTTTGCTCGTCGAGGTACTTCAGCTTGACCGACAACATAGCTGCCTGAATTTCATCCAGCCGACTATTCATTCCACGATAAAGATTTTTGTACTTCTCGTGCGAGCCATAGTTACGCAACGCCCGAAGTGTGGATGCTAGCATATCGTCATTAGTGGTTACCGCTCCAGCATCGCCAAGAGCACCAAGGTTCTTGCCTGGATAGAAGCTAAAACCGGAAGCGTGGCCCCAGCCACCTGCTTTTCTCCCATTAACGTTCGCTCCGTGGGATTGGGCGGAATCTTCCAGAACGAGCAAACCAGAGCGTTCAGCTAGAGCCATGATTGCTGGCATGTCCGCAAGGCGCCCATACAAATGTACAGGTAGAATAGCTTTGGTTTTAGCAGTAATGGCTGCTTCGGCACTGATCGGGCAAATATTAAACGTTGCAGGATCAGGCTCAACCAGAACAGGTACCAACCCATTCTCCGATATGGCAAGGATGCTTGCGATATATGTATTGGAGGGAACCAGAATTTCGTCGCCCTCGCGCAAATAACCAAGTTCCTTCCAGGCTCGGATTACCAGTACCAAGGCGTCCAGTCCATTGGCAACACCAATACAATGCTTAGTTCCGCAGTATTCAGCATAGCTGCTTTCAAACTGTTGAAGCTCGCTTCCCCCGATATACCAACCAGAATCAATAACGCGCGTGCACGCCTCAATCAACTCATCGCGGCACGCCTGGTTGATGGATTTCAAATCAAGGAAACTTATCATTAGCTCAGATACCTAATAACTTTAGCTGGGTTACCCACAACAACCGCCCGGTCTGGGACATCGGAAACGACGACCGCCCCAGCGCCTACCATTGCCTTTTCGCCGATGGTCACACCGGGCAATATTGTCGCATTCGCACCAATGCTCGCGCCCTGTTTGATAGTGATGCCGGAGAATGATTCCGGATAAACCTTGGAGCGCGGCATGACGTCATTGGTGAATGTTGCGTTTGGACCGATAAAAACGTTATCGGCGACGACAGTTCCTTCCCAAAGGAAGACTCCCGACTTGATCGTCACGTTGTTGCCTACCGTAACGCCATTTTCGACAAGCGTATGTGCACAGATGTTGCAATTTTCACCAATAACGGCGCCATCAAAAACTACCGCAAATTGCCACACTCGAGTATTTTTTCCAATGCGGGTGCTTTTGACATCGGCGAGTGCATGGATTTTAGGCATGCTTCGTCAGCTCCAAGAAGGCGTCATAGTTTCTGATGTAATCCTGTTCGTCATAAAAGTCACTGGCCAGGACCAGCAGCACGCAGTCCGCGCTAAACTCGTGCATTTCGTGCCAAATCATCTTATCGATGACAATGGCTTTATCAGGCGCGTCCAACCAGACTTCCGCTGTCGTCAGGCCGTCATCCATTTTCATCAGGCAACGCCCGGAAACACAGACCGCGACCTGAACAAGCTCTTTGTGTGCATGAAAACCGCGTGGTACGCCTGCCTGGGTATCGGTCAGGTAGTACACCCGCTTGATGGAAAATGGAACTCCCCTATTGTTTTCAAGCGCAATTAGATGACCGCGTTCGTCACCCAACGTTTTGATGTCGAGGAATTTTATCAAACTCATTACCGCGTCACCGGTAAACTATCGATCATCGGTGCTTTATCATCTTTTTCACTGATGATGTAGTCGTCAGAACCCGGCCATTGGATATTCAATTTAGAATCGTTCCAATGAAGCGCGCCTTCAGACGCTTTATCGTAATAGTCAGTAGTCTTGTACAGGAAGTGCGTATCGTCTTCGAGCGCAACGAATCCATGAGCAAAGCCTTCCGGAATCCACAGCATGCGGTTATTGTTGTCGTTCAGTTCAACGCCGACCCATTGTAGATAGGTCGCAGAATCCGGTCGAATATCCACAGCTACATCGAACGCAGAGCCTCGAACGACCCGAACCAATTTACCTTGTGCATGAGGAGCCCGCTGAAAGTGCAGACCTCGAAGCACGCCCTTTGCCGAGCAGGAGTGATTATCCTGAACAAAAGCACGCGGCACGGCCAAACCTAGAGTCTTCAGCGCGGCATGAAACTTTTCTTCATTGAAACTTTCCATGAACCAACCACGTTCATCGCCATACACAGCAGGCTCAATGATTACTACGTCCGGAATCGAGGTTTGCATCAGCTTCATGCGCCAGAAGCCTCCGTAAGGATTTTTTGCAGGTATTGCCCATAACCGGTTTTTTTGAGTTTTTCAGCTTGCTCACCAAGCTTCTCTGGAGTGATCCAACCGCTATGAAAAGCGATTTCTTCCAGGCAGGCCACTTTAAGGCCCTGACGGTGCTCAATGGTATGAACGAAGTGGCTTGCTTCCAGCAGCGACTCGTGTGTGCCCGTGTCCAGCCAGGCAAAGCCTCGACCGAGCATTTCAACGGTCAATGACTTGTCGTCGAGGTAAGCTTTGTTTACATCGGTAATTTCAAGCTCGCCACGAGACGAGGGCTTGATGTTTTTCGCGATTTCAACAACGCGGTTGTCGTAGAAATACAAACCGGTTACAGCATAGTTGGACTTCGGACGCGCCGGCTTTTCCTCGATACTGAGTGCCCGACCACTGCTATCAAACTCGACAACGCCAAAGCGCTCAGGATCAGAAACGTGATAACCGAATACGGTTGCGCCGGTAGTCTGAGACATTGCAGAACGCAGGTTGTCGGAGAAATGCTGACCGTAAAAAATATTGTCGCCCAGGATCAGGCAGCATGGGTCTTCACCGATGAACTCTTCGCCGATGATAAACGCCTGTGCCAGGCCATCAGGGCTTGGCTGTTCGGCGTAAGTCAATTCGATGCCGTACTGACTCCCGTCGCCGAGCAGCTTTTTGAAGCAAGGCAAATCTTCCGGGGTAGAGATAATCAGGATTTCCCGCATTCCGGCAAGCATCAGCACGGACAGCGGGTAGAAGATCATCGGCTTGTCGAAAATTGGAAGCATCTGTTTCGACACGCCCAACGTCAAGGGGTGCAGGCGCGTACCGGAACCGCCTGCCAGAATGATGCCTTTGCGTTTGATGACCGTCATTTCTCTAACACTTCCTTTAACATCCGGGTCACACCACTGCGCCAATCTGGCAAGTGGATGGAAAAAGTCTTGCGCAGTTTCTCGGTATTAAGCCGGGAATTCAATGGCCGACGTGCAGGGGTTGGAAATTGCGCCGTTGAAATCGGATTGACAGCCTGCGCTTGTAAAGGCATGCCGCTCGCCTTGCCGTAGTCGATGACCAGACTTGCGTACTCATGCCACGTAGTAAACCCGGCGGCCGCCAAGTGATAAATACCTGCAACCGCAGGTTCAGCCAGCGCCTTTCTAAGGGTTACCGCGGTAACGTCTGCTATCAAATCAGCGCCGGTTGGCGCTCCGATCTGGTCCGCAATGACGTTGAGCTCTGGGCGATCCGTGGCGAGCCGCAGCATCGTTTTAGCGAAGTTGCTACCCCGCGCGCCATACACCCAACAGGTACGGAAAATAAGGTAACGGCAGCCTGATTGGACGATGGCCTGCTCTCCCATCCACTTGGTCATGCCATAGTAGTTGACAGGAGATACAGCGTCGTCTTCCTGCCAGGCCGCAGTGCCGTTTCCATCGAATACGTAATCCGTGGAAAAGTGCACAAACCAGCAGCCCAGTTTTTGTGCCTCTTCGGCGATGACCTGGACCGCAGTTGTATTAATTTGCAAGGCCACGTCTTTATCGGACTCAGCCTTATCCACAGCAGTATAGGCGGCCGCATTGACGATGATGTCGGGAGCCACGCGCTGAATGGTGGTCCGCAAACCCTGAAGGTCAGCAAGATCACCGCACAGACCATTGTCGACGTGGCGATCGAGAGCCACGACATCGCCTAACGTTGCGAGGGAGCGTTGAAGCTCCCAGCCAACCTGTCCATTTTTACCCAGAAGCAAGACTTTCATGTCAGGCTTGTCGTTCAGCATAGTTTTGATCGATCCATTGCTGGTAACTGCCGCTCTTGACGTGATCGACCCAAGGCTGATTGTTCAGGTACCACTCGACAGTCTTGCGAATCCCCGATTCAAACGTTTCTTCGGGAGTCCAGCCCAGCTCGCGCTGAATCTTGCCGGCATCAATGGCGTAACGCTGGTCGTGCCCTGGGCGATCCTGCACGTAAGTGATGAGCTTGGCGTGCGGGCGATGTGGGGATTCTGGACACAACTCATCCAGCAGCGCGCATACGGTATGGACCACTTCGAGGTTTTTCTTCTCGTTATGGCCACCGATGTTGTAGGTTTCGCCGACTTCGCCTTCGGTCACTACTTTATAAAGCGCACGGGCGTGGTCTTCTACGTACAACCAGTCACGAACCTGATCACCTTTGCCATAGATAGGCAAAGGCTTGCCTTCTAGCGCATTCAAGATAACCAATGGGATCAGCTTTTCTGGGAAATGGCATGGCCCGTAGTTGTTTGAGCAATTGGTCACGATCGCCGGGAGACCGTAAGTTCTGCTCCAGGCTCTGACGAGGTGGTCCGAGCTTGCCTTGCTCGCGGAATAAGGAGAGCTTGGCTGGTAAGGAGTCTGCTCGGTGAAAAGGTCTTCAGGACCTTCAAGATCACCATAGACTTCGTCGGTGGAAATGTGATGGAAACGAAAGTTCTCTTGTGCTGGTGCGTCCAGGCTCTTCCAGTACTGCCGTACCGCTTCCAGCAACGTATAGGTGCCGACGATATTAGTCTGAATGAAATCCGAAGGACCGCTGATGGAGCGGTCAACATGGGACTCTGCGGCAAGGTGCATAACCGCATCAGGCCGATGCTCATCAAACACACGCTGCAACTGGGCAGCGTCGCAAATGTCGACACGCTCAAAGGCATATCGGTCATTTTTGGCGCTTTCACCCAGTGACTCCAGATTACCGGCGTAGGTCAACTTATCCAGATTGACCACCGAATCCTTGGTGTTGGCGATGATATGCCGGACAACTGCCGAGCCAATGAATCCAGCGCCACCGGTCACTAATATTTTCAACTTTATCTCCTTAAACTGAAATAGCGCGTCACTTACGCTATCCGTCATTGATGCTTACCGTGACACGGTTTTCGCCTGTCGGACGGTGTCGTCTTGATTTCGCCATGTAGGGTCAGCGTAGTTCCAGACTCGCCGTTCAAAGCATGAACCAACCTCGGGCTTGCGGTCGAACTGCCTGAACCCATTACTAACCGCATTTTACACTCGTTGCGTACCTGAAGCGGCTCAGAGCCTTCACGGACGCGCATTTCCGACAAGCAACCCAATCGACCTTGCCAACGCCGGCTCGGAAGCGATGCAAAGCATCGCACCCCCGGACGCTGAGACCTTCAGATCTTACAAGTTGCCATTTGCGCCAAGCGTAGCCGATGATTCGGCATTCTTACGCTTGGAGACAAAATGCTGTAATAGTGCAATCGCGCAGCCCAGCAGCCCACCAATGATTAGCCCCAGAAACACAATCAGGACTTTCTTCGGCTTAATCGGCGAAACAGGCAGATCCAGGACGCCATCGTGGCGGTACACCGCGATATCAAATTTTTCCGCCTCGACTTGCTTGTAGAAGTCAGCTCGCTTCTGGAGTTTGCGCAAACCAGGAGTGAACGGGTCGTCGGAACCTCGATTTTCAAGGTTTTTCAGCTCCGCCTCCAACGCCTTGCTGCCACGCAGGTAACTGTTGCCTTCTAGCATGCCTCCAGCCAACTTATCGGAGCCGCTGCCGGAAAACACAACTGTATTCTCCAAGCCACTGGATTTGGCGATAGCCAAGGCTTCACGAATTTTGCTAATGGTGTCTTGACGTACGTTATGGCTAGACTCTCGAAGAGTATTTATCTCCAGCTGCAAGCTACGCTTTATTACCGCAGCCTCTTTTTTCGCATTCTGAGTCAATTCGCGCGATGTACTTTCTCCGACCTGACTTACGTACAAATCAACCCATTGCACTGCACGCTCAGGATTAGAATCCTGCAGGGAAACCGACCAGCGCCCGTCCTCTTCTTTACCAACTGGCGCAACCTTGAGATCTTTCGAAAACGAATCATACAAAGCTCCGTTTGGCGATTGAGGAGCTCGAGCCCCCAAAGCTGGCAAATAGATAGACTCAAAAAAAGCTCGCCGCTGCGATTCGGATTGAAGATTACGCAAAAACGCCTTATAAACCTGATCGACTGAAATAGGCTTCAAATCCGATTCATTACTGCGACCAAAGTTGAGATTGGCGATATCATTCACGGTCGGCGGCAATATAAAGTACTTCGACTCATATATAGGAGTTGATAAGAATGCGTACACGGCAGCGGCAAGCCCCATCGTCAGGGTCATACCCACGACAAGCCACTTTCGCTTCCAAACTGCCCCGACGACTTCAAAAAGATCTATTTCAGATGAAGAGTTAATTGTGTTATTACTGTTTTGCATAGGTTATTTTAGCCCTTCACTTATTCTATTCTGCAAGTCTGGTACAAAATCCATCCACCTACCTGATAGCCTTTCGGACCCATTCCAGCGTCCGCTTATCGACTAACCACCCAAAAAGAGAATGAAAAAAGGGGGGCAATGCTATCAGAGCCCTACGGCCGGGGCGAAATAATAACACGGACACAGACCGCTTTCCCGATGAGAAGCGACCTCCCTGGTGATCCAAGGAGGTTTACAGGCGCCGCCCACCCCTGAGACCGATGAGCCACGCCAGAAGCGGCCCCACCACCATCCCTAAAAGCAGCGCTGAAATAATGTAGCCTGCAATCGGCATTTGCGCAGAAGACCAACCCAGGAAAAGAAGTGAAGTCGGTTGGCGATTTTCCAGGATAAATACGATCACCAAAAAAATCAGCAGCAAAATCAATAAAGCCAGCGCAATCCGCTTGAGCCTTTGCACATCACACCTCCCTTACGAATCCTAAAATCAAACCCCCTCCTCCTCATCCTCATTCACCCGATCCCGCAATTCTTTGCCCGGCTTGAAATGCGGAACAAACTTGCCATCCAGGCTCACCGACTGCCCGGTCTTCGGATTACGCCCTACCCGTGGCGCGCGGTAATGCAATGAGAAGCTGCCAAACCCACGGATCTCGATGCGATCACCGGTGGCCAGGCATTGGGACATTTGCTCGAGCATGGTCTTGATGGCCAGCTCCACATCCTTGGATGAGAGCAGCCCTTGATGGGTGACAATTCGTTCGATCAACTCCGACTTCGTCAT

Protein sequences of DBSCAN-SWA_3

>NZ_CP014870|4746553:4754157|4749098_4749992_-|WP_064678973.1|DBSCAN-SWA
MTVIKRKGIILAGGSGTRLHPLTLGVSKQMLPIFDKPMIFYPLSVLMLAGMREILIISTPEDLPCFKKLLGDGSQYGIELTYAEQPSPDGLAQAFIIGEEFIGEDPCCLILGDNIFYGQHFSDNLRSAMSQTTGATVFGYHVSDPERFGVVEFDSSGRALSIEEKPARPKSNYAVTGLYFYDNRVVEIAKNIKPSSRGELEITDVNKAYLDDKSLTVEMLGRGFAWLDTGTHESLLEASHFVHTIEHRQGLKVACLEEIAFHSGWITPEKLGEQAEKLKKTGYGQYLQKILTEASGA
>NZ_CP014870|4746553:4754157|4748134_4748539_-|WP_064678971.1|DBSCAN-SWA
MSLIKFLDIKTLGDERGHLIALENNRGVPFSIKRVYYLTDTQAGVPRGFHAHKELVQVAVCVSGRCLMKMDDGLTTAEVWLDAPDKAIVIDKMIWHEMHEFSADCVLLVLASDFYDEQDYIRNYDAFLELTKHA
>NZ_CP014870|4746553:4754157|4746553_4747681_-|WP_064678969.1|DBSCAN-SWA
MISFLDLKSINQACRDELIEACTRVIDSGWYIGGSELQQFESSYAEYCGTKHCIGVANGLDALVLVIRAWKELGYLREGDEILVPSNTYIASILAISENGLVPVLVEPDPATFNICPISAEAAITAKTKAILPVHLYGRLADMPAIMALAERSGLLVLEDSAQSHGANVNGRKAGGWGHASGFSFYPGKNLGALGDAGAVTTNDDMLASTLRALRNYGSHEKYKNLYRGMNSRLDEIQAAMLSVKLKYLDEQTIHRRKIADLYTNNIQHPAITLPVVSQFNPLENSSHVWHVYTVLCQDRDALQNHLLANNIQTLIHYPIPPHQQQAYSELARYSLPVSEKIHREILSLPMGPGLLLEEARAVVAACNSFQSDMT
>NZ_CP014870|4746553:4754157|4747680_4748142_-|WP_064678970.1|DBSCAN-SWA
MPKIHALADVKSTRIGKNTRVWQFAVVFDGAVIGENCNICAHTLVENGVTVGNNVTIKSGVFLWEGTVVADNVFIGPNATFTNDVMPRSKVYPESFSGITIKQGASIGANATILPGVTIGEKAMVGAGAVVVSDVPDRAVVVGNPAKVIRYLS
>NZ_CP014870|4746553:4754157|4753860_4754157_-|WP_003218804.1|DBSCAN-SWA
MTKSELIERIVTHQGLLSSKDVELAIKTMLEQMSQCLATGDRIEIRGFGSFSLHYRAPRVGRNPKTGQSVSLDGKFVPHFKPGKELRDRVNEDEEEGV
>NZ_CP014870|4746553:4754157|4748538_4749102_-|WP_064678972.1|DBSCAN-SWA
MKLMQTSIPDVVIIEPAVYGDERGWFMESFNEEKFHAALKTLGLAVPRAFVQDNHSCSAKGVLRGLHFQRAPHAQGKLVRVVRGSAFDVAVDIRPDSATYLQWVGVELNDNNNRMLWIPEGFAHGFVALEDDTHFLYKTTDYYDKASEGALHWNDSKLNIQWPGSDDYIISEKDDKAPMIDSLPVTR
>NZ_CP014870|4746553:4754157|4752290_4753373_-|WP_064678975.1|DBSCAN-SWA
MQNSNNTINSSSEIDLFEVVGAVWKRKWLVVGMTLTMGLAAAVYAFLSTPIYESKYFILPPTVNDIANLNFGRSNESDLKPISVDQVYKAFLRNLQSESQRRAFFESIYLPALGARAPQSPNGALYDSFSKDLKVAPVGKEEDGRWSVSLQDSNPERAVQWVDLYVSQVGESTSRELTQNAKKEAAVIKRSLQLEINTLRESSHNVRQDTISKIREALAIAKSSGLENTVVFSGSGSDKLAGGMLEGNSYLRGSKALEAELKNLENRGSDDPFTPGLRKLQKRADFYKQVEAEKFDIAVYRHDGVLDLPVSPIKPKKVLIVFLGLIIGGLLGCAIALLQHFVSKRKNAESSATLGANGNL
>NZ_CP014870|4746553:4754157|4749988_4750882_-|WP_064680769.1|DBSCAN-SWA
MKVLLLGKNGQVGWELQRSLATLGDVVALDRHVDNGLCGDLADLQGLRTTIQRVAPDIIVNAAAYTAVDKAESDKDVALQINTTAVQVIAEEAQKLGCWFVHFSTDYVFDGNGTAAWQEDDAVSPVNYYGMTKWMGEQAIVQSGCRYLIFRTCWVYGARGSNFAKTMLRLATDRPELNVIADQIGAPTGADLIADVTAVTLRKALAEPAVAGIYHLAAAGFTTWHEYASLVIDYGKASGMPLQAQAVNPISTAQFPTPARRPLNSRLNTEKLRKTFSIHLPDWRSGVTRMLKEVLEK
>NZ_CP014870|4746553:4754157|4753605_4753833_-|WP_064678976.1|DBSCAN-SWA
MQRLKRIALALLILLLIFLVIVFILENRQPTSLLFLGWSSAQMPIAGYIISALLLGMVVGPLLAWLIGLRGGRRL
>NZ_CP014870|4746553:4754157|4750883_4751954_-|WP_193408115.1|DBSCAN-SWA
MKILVTGGAGFIGSAVVRHIIANTKDSVVNLDKLTYAGNLESLGESAKNDRYAFERVDICDAAQLQRVFDEHRPDAVMHLAAESHVDRSISGPSDFIQTNIVGTYTLLEAVRQYWKSLDAPAQENFRFHHISTDEVYGDLEGPEDLFTEQTPYQPSSPYSASKASSDHLVRAWSRTYGLPAIVTNCSNNYGPCHFPEKLIPLVILNALEGKPLPIYGKGDQVRDWLYVEDHARALYKVVTEGEVGETYNIGGHNEKKNLEVVHTVCALLDELCPESPHRPHAKLITYVQDRPGHDQRYAIDAGKIQRELGWTPEETFESGIRKTVEWYLNNQPWVDHVKSGSYQQWIDQNYAERQA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064678969.1|4746553_4747681_-	DegT/DnrJ/EryC1/StrS family aminotransferase	E5ES42	Bathycoccus_sp._RCC1105_virus	5.6e-42	30.5
WP_064678970.1|4747680_4748142_-	N-acetyltransferase	NA	NA	NA	NA
WP_064678971.1|4748134_4748539_-	FdtA/QdtA family cupin domain-containing protein	NA	NA	NA	NA
WP_064678972.1|4748538_4749102_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	3.3e-43	49.2
WP_064678973.1|4749098_4749992_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	2.5e-109	67.6
WP_064680769.1|4749988_4750882_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	8.4e-33	34.9
WP_193408115.1|4750883_4751954_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	3.6e-99	53.9
WP_064678975.1|4752290_4753373_-	LPS O-antigen chain length determinant protein WzzB	NA	NA	NA	NA
WP_064678976.1|4753605_4753833_-	LapA family protein	NA	NA	NA	NA
WP_003218804.1|4753860_4754157_-	integration host factor subunit beta	A3E2K9	Sodalis_phage	1.5e-10	41.1

Sequences of DBSCAN-SWA_4

Nucleotide sequences of DBSCAN-SWA_4

>NZ_CP014870|6282764:6331603|DBSCAN-SWA
CTCAACAATCCGGCTTATCCGCCGTAAACCGCCGAGCCGGATTCACCGCCGCCCCAAACTCACGCAACGCCTTTGCCCCAATCAGCAACGGATAATTAAAGCTGCTGCGGTCGGTCAGGTTGACCTCGACCGTGCGCTTGACATTGCCCAGGCACAGCTCCAGATCAACCACTGGCCGCTTGGTGGGTGCGACGTCTTCATCATCATCGTCGCCTTCTTCCGAGCGGGTCTTGATCTTGCTGATCCGCGCGACTTTGTGTTCGTAGACCTTGTTGCTCGCATCTTTGGTGCCGAGGCGGAAACGTACCCATTCGTCGCCGTCACGGGTGAAGGTTTCGATGTCCTTGGCCGACAGCGAGGCGGTCAGGGCGCCGGTGTCCATTTTGGCCTTGAGCACTTCGCCGCCGATTTCCGGCAAGGCGATGTATTCGTAGCGGCCGTACAGGGTCGGCTCGGCGGCCAGGATGGGCAGGGCCACCAGGGAGAGCAGTGCAAGGAGGGATTTCACGTAATGGGCTTCCTTGAAGAGTGGGCAGCGGGATTTTAGACCGTTATCGATTAGATCGTTCCACGCTCTGCGTGGGAACGATCGGTAAGCAGCTGGACTTGCCCCTACCAAACCGGACACCAATTCCCCGTTAAATTGATGCTGCCGCTAAGCGCCTGAACTCCCTCGGAGAGCGATAGTTCAAGGCGCTGTGTGGATGCTGCTCGTTGTAGTGTTCGAAGGCAATTGCCAAATTACGCAGTGCGGTTTCCCGATCCGGTTTGGGCATGTGTGCCACATAGTCACGCTTGATCGTCTTCACGAAGCTCTCAGCCATGCCGTTGCTCTGCGGGCTGCGCACCGGTGTGGTCACCGGCTGCAAACCGATCTGCCGAGCAAACAGGCGTGTCTGTTCGGCGGTGTACGCCGAGCCGTTGTCGCTCAGCCATTGCACCGGCGTAGTGGGCAGTTGATCACCAAAACGCTTCTCCACGCTTTCCAGCATCAAGTCGCGGATATCATCGCCGCTGTACCCGGTCGGGCTCGCGACCCAGCCGATGGCTTCGCGGTCGCAGCAGTCCAGGGCGAAGGTCACGCTCAGTTTGGCACCGTCCTCACAACGGAACTCAAAGCCATCCGAGCACCAACGTGTATCACTGGTCTTCACGGCAATACGGCCTTCGTGCCGACGCGGCACACCGGGCTGTTTGATCCGCCGCTCAAGCAGCAAGTTGTGATCACGCATGACCCGGTAAACCCGCTTCACGTTGATCGCCGGCAGCGACCGCTTTTCACGTGCACGACGCAGCAGTCCCCAGACGCGACGGTATCCATAGCTGGGCAGTTCGCTGACCTCTTGCTGGATTTCAGCGACCAGCTCTACATCGTTCACAGGCCTGCTTCGCCGCACTTTGGGCGATACCGATTGCTTGATTCGAACCGTTAATTGCGAGCGCGCCACACCGAGACATTCGCTGACCAGCTTCACTGGTCGTCCCCCGGCAACAAGGGTGAGTGCGCAATCCATTTTCGCGACCGGGCGATCTCCACGGCCTCTTTGAGGATTTCGGCTTCCATCGTTTTCTTGCCCAGCATCCGTTGCAGTTCACGGATCTGCTTAAGCGCATCGCTCAGCTCGGAGGCAGGCACCACGGCTTCGCCAGCACTGACCGCCGACAGGCTGCCGTCCTGATACAACTTGCGCCACAGGAACAGTTGGTTGGCATTGATGCCGTTGCGCCGAGCGACGACCGACACACTTTGTCCTGGCTCAAGGCTCTCGCGAACCATGGCCAGTTTTTGCTCCGGGCTCCAGCGGCGCCGCCGCTCCTGGCCCAAAAGCTCCCCACTCTTATCGTTGCTGTTAGTCATAAACATAACCGTTTGCCTATCCCTTATCGTAAGGGGGAAACGGTGTCCTGTCTTTCACGGGGCTCGTTCAGCAGCCTTCCACACGGCGCGTGGGAACGATCAGTGGAGGGAGGTTAGCGGTTCAAAGGTGAAACATTTGTCACCGTCGATTTGGCCTCTCGAACGAAGCTGCCTATCATGGCGCGCCCAAACGTTTTCAAGAGTGCCCCATGCGCCGCCTGCTCACCGGCTGTTTCGTTACCCTGTTGCTGTTGCTCAATACCCTGGCCCTGTTCGGACCGCTGATGGTGTTCGCCTTGCTCAAGCTGGTCCTGCCCGGGCGTTTTCGCGATTACGCCTCCTGGGCGGTGATGTGGATCGCCGAGACCTGGGCCGAGATCGACAAGCTGATCTTCCAGCTGTGCATCCCCACCCGATGGGACATTCGCGGCGGCGATGACCTGCGCCGCGACACCTCGTACCTGGTGATCGGCAACCATCAATCCTGGGTCGATATCCCCGCGCTGATCCAGACCCTGAATCGACGAACGCCGTTCTTCAAATTCTTCCTCAAGAAAGAATTGATCTGGGTGCCCTTCCTCGGTCTGGCCTGGTGGGCGCTGGATTACCCGTTCATGAAGCGCTACACCAAGGCGTTCCTGGCGAAGAACCCGGAGCTGGCCGGCAAGGACCTGGAGATCACCAAGGCTGCCTGCGAGCTGTTCAAGCGCCAGCCGGTGACGGTGGTCAATTACCTGGAAGGCACCCGTTTTACTGCAGCGAAAAGCCGTCTGCAACAATCACCCTTCACTCACCTGCTCAAACCCAAGGCGGGTGGCGTGGCCTTTGTGCTGGCGGCGATGGGCGAACAGCTTGACGCCGTTCTCGATGTGACGGTGGTGTATCCGCAGCAGCAGATTCCGGGGTTTTGGGACTTGATCAGCGGTAACGTGCCGCGGGTGATCATCGATATCAAGACCCGCGAACTCGACCCTGCGCTGTGGCAGGGCGACTACGAAAACGATCCGGTGTTTCGCCAAACCGTCCAGAACTGGGTCAACCAGCTCTGGATCGAAAAGGACCGGCGCATCGACGCCTTGCGCGCCGAGCGCCCCTGAATCAGCTACCGATGCCGGTGCCGGCGCCCCAGATCCCGCCCAGACTTTGCAGCAACGAACCGCCAACGCCCTGTTGACCGAAGTATTGCAGGATTAGCGGGGCAAACTGGGCGATCATGCCAGTGTCCATGCCCAAGGCGCTGAAGGCGTTGTTCAGGTCATTGGTGCTCTTGACGGCGCCCAGTGCGTTGTCCAGGCCGGCCATCTTGCCGGAGGAGCCGAGCAAACCGGCGAGCGCGCCCAGTTCACCACCACCCGACAGCTTGTCGATACCCGGCACGCTTTTGGCCAGTTCCGAATAGTCGGTCGAACTCAATTGATTCTTCGCCAGCCCCAGCATCGCACTGGTGCCGCCAACGGCCTGTTGTGGCGTCACGTTCAACTGGCTGAGCGCACTCAGCAGGCCAGCCGTCTCGGAAGTGGGCGCGGCCGTGGCGGCGGTGTTATCGCCTTTCATGCCGGAAATGGCATTGGCCGCATCGCTGAAGCTGAACTGAGCAAAGACCGGGCTGGCCGCCAGGGTCATGAGCGATGCCAGTGCAAAACCGCGTGAAATCTTCATTCAGACATCCTCTTGTGCCATGAAAACCGCCTGTTGATAGACGGAAAAACTGCCGGTTTGACCGGGTATTGGCCGGCATGTTCCTCAGCGCTGCGCCCATTTTTACGCCCACTCACGTGAATACAACGTGAAACCAACCATGCCGCTCGATAAAACGGTTTTCGCCGTTCGAACCTAGCAGTTCTGCTAGTAGGCAATCCGGACCGATTGCATCAAAGTGAAAGCTTGGATAGATGGATCCTTCAGGAGCCCTAGTCATGACTGCTCGCCGCGAAATCCCACTCTGCCATTACCGGTACGACCCACTGGATCAACTGATTAGTTGCGCGACGTCCGCGCAAGCCAACACTCAGCGTTTCTACCTCAAGGATCGCCTGGCCAACGAGGTTCAAGGTGCGGTGCAGCGTTCGATCATGCAGCATGGGGATCAACTGCTGGCGGAACAACGCTGTGAAGGCGGCCCACTGGAAACCACCATTCTCGCCACTGATCAGCAGCGTTCAGTGTTGACTACCCTCGACTCAACCAGACCGCATACTCTCGCTTACACACCCTATGGTCACCGTATTCCGGAAAACGGCTTGCTCAGCCTGCTCGGCTTCAGCGGCGAACGGCCAGATCCAGTTACGGGGTGCTATTTGTTGGGAAATGGCTATCGTGCGTTTAACCCTGTGTTGATGCGGTTTAACAGCCCGGAAAGTTTAAGTCCGTTTGGGGAGGGAGGATTAAATGCATATGCTTATTGTGTGGGGGATCCGATTAATCGAGTGGATCCGACAGGACATGTTGGAGAGTGGATAAGTAAACTCTTAGGTTTTTTAAATAATGCAAGCGGCACCGTGGCAGTCAACCAATCCGTGTCGAAAAGTAGATACATGAAGAACATGACTATCTTGGGTGATGGAGCGTTCACATTTGACGATATTTTCAAGGGAAAACAGCGCCTAAACATATCAGCGCACGGAATAGAAACACCTTTCGATCAGCCTTCAAAAATGGTGATGAACAGAGAAACCTGGCTCCCCTCTCAAGTGTATACCGAAATGAAAAACCAAGGATATGATTTCAGTTCCTATGCAGAAATTCGTTTGATCTTTTGCCATTCTGCGAATGGCGGACAGCAATCATTTGCATCACAATTTCAGAAACTGACGAATATAAACACGAAGGGCTATCTCGGAACTGTCGTTGAAAAACATCCCATTGACGATGTTATGAAGGTTTTTGAAAAAGGCAAAATCAAATATCCTGACAACCCCCAGAAATATCTTCGTGAGCATTACAATAAAGAAAAGTCATATACCTACAAAAAACGCTATGGCCTCATAGCCGTCAATTACCACTCAGTTAGATTCCCATCATAGTGCAAAAAAATGACGACATCACAAGGCCATATGACGATCCAGCTGCAGCGATTTAAAGCAAATGCCCTTATCTTGCGATACGGGCATTTTCTTTAAACGATGACCAGGTTGCCAGGTTTTTACACGGCCTGACCACGTCGCCCTCTTCTTATTTGAAAATGAATGCTCAGCTGCCCATTTTCGTGGCCGCATCCACAGCACCTGGATCTTCAGTCACGTAGAGGTCAGGGATACCGATCTTGCCAGCCATGCGAACCACACCCATCAGGGAGTTGAGCACGGTGGCCGGAGCCTCGTGTTTCACACCGTCATGACCATGACCACGCGCTTCGAAGCCCACGGCGTCGACGGCGTAATCCACTTCCGGCTCGCCCAGCAGCGCGGCGATCTGCTCGTGCAGCGGTGTGTCCGGGAACAGGTCGACGATTTCGAAACCATTCAGACATCCTCTTGTGTCATGCAAACCGTCTGACGGAAAAACTGCCGATTGAACCGGGCATTGGTCGGCATGCTCCTCAGCGCGGAACCCATTTTTTACGCCCCCTCACGTGAATACAACGTGAAACCAACCATGCCGCTCGACGAAACGGTTTTCGCCGTTCGAACCTAGCAGTTCTGCTAGTAGGCAATCCGGACCGATTGCATCAAAGTGCAAGCTTGGATAGATGGATCCTTCAGGAGCCCTAGTCATGACTGCTCGCCGCGAAATCCCACTCTGCCATTACCGGTACGACCCACTGGATCAACTGATTAGTTGCGCGATGTCCGCGCAAGCCAACACTCAGCGTTTCTACCTCAAGGATCGCCTGGCCAACGAGGTTCAAGGCGCGGTGCAGCGTTCGATCATGCAGCATGGGGATCAACTGCTGGCGGAACAACGCTGTGAAGGCGGCCCACTGGAAACCACCATTATCGCCACTGATCAGCAGCGTTCAGTGTTGACTACCCTCGACTCAACCAGACCGCATACTCTCGCTTACACACCCTATGGTCACCGTATTCCGGAAAACGGCTTGCTCAGCCTGCTCGGCTTCAGCGGCGAACGGCCGGATCCAGTTACGGGGTGCTATTTGTTGGGAAATGGTTATCGGGCGTTTAATCCAGTGCTGATGCGGTTCAACAGTCCGGACAGTTGGAGTCCGTTTGGGGACGGTGGACTGAATGCTTATACGTATTGTGTAGGAGATCCGATAAATCGGGAGGACAAAACAGGACATGTTCCAAACTGGTTCTCCAAGATAAAAGCTCTGATGACTCGCGGAAATGGATTTAAGCGTCTCTCATCAACTTCGCTTGACTCAGCCCGTTCAATGGTTAGCACGAAAAGTGCGCTTGCTACAGGTTCTGCAACTCCACACGCTACGGCCGGGACGCTGCTGCCTGGCCTTGATCCATCCTCGACGTCGCGAAATGCAACAACAACTGCGAGCAACTCGACACCAAGCGCCAGTGGCGTATGGGATGTGAAAAACACTTTATACGATGCTAATTCCGCCATAGAAAGCGCACAATTGAAAAAATATAGCGGATCGAAACTAAAGTCATTAAAAAAGGCTGCAAAAAAACTGGAACACTACGATAACAACAAGGAGAGATTGCTATCAAAACTTAAAAACAGGCAAGAAAACCTTATTGAGTACGGCTTAGTAAAACCAGAAAACCTTCCAACACCGCAGCAACTGGCACTGGAAAAAATTAACGAACAACGCAAAAGCGTTATCTTTTTAACCGACGAACTCAATAAAAAACTCAGAGGAACGTAAATCAACTAAAGCTTCGAGTTGAGCACATACCCAACACATGACCTCTCATAAAAAAGAGCGACCACTGGTCGCTATTTTTTAGCCTTTCTTACGCCGCACCAAACAACTTATGCTGATCAATCACAAACTTCTTCGGTACACCCGCATCAAACTCGCCATACCCGCGCGGCGCGTCATCCAAGCTAATCACCTCAACGTCCACGATGTCAGCGATATGAATACGGCCCCACATGATCGCTTGCATCAACTGACGGTTGTACTTCATCGCCCGCGTCTGCCCATCGTGGAAGTTGTGAGATTTAGCCCACCCAAATCGAAACGGACGCTTAGGCTGCCCATTTTCGCGACGGCATCCACTGCACCTGGATCTTCGGTGACGTAGAGGCCCGGGATACCGATCTTGCCGGCCACACGCACCACGCCCATCAACGAGTTGAGCACGGTAGCCGGAGCCTGATCCATAAATAAATCTGTCCCCTTAAATACTGTTAAATACAGTCCCCTTAAATACATACATAAGTCTGGCTGCTGCTTGCTGCCGTCCCCTGCTGGCTCCCTTGCTGTGCACTGATAAATTCAAGAGGCTTTCAATCGGTTACAACTACTATCACAAGTGATAGTAGGACTGAAGACTGTAGTTCGTAAAGATGACCACTCCCAAACAATGGAGTATCAATCATGCGATCAACAATTACTGCTAGTTTACTCATTACATTAATGACCATCGGAAACGCTTATGCCGCAAGTTCTGCCTGCCCGGCCGTCAGCGACATCATTCAAGTCAAGGATGAACAGGAAGGAGGCTATGAATATTTCGCCCCTGGACCTGATAAACGGGTATGGGTTGGCTCCAACCCTTATGCTGAAGAGCATCACATCGAGACGTTTGAATTCACCGGTGGGTTGTACCGGGATATCAGTTCGGAGGGCAATAAGTTTGTGGTGTCCTGCGACTACGAGGGAGAGGAGTTTCTCGCGTTCACGCGCTTGACGCTGTACTCCTTCAATGATTGGAAACCTGCTACCCATACGCTTTGGAAACGCGAAGTTAACAAACAAGCGCTCCTTAACAACAAGAACGCCCAGCACGTGGAAACCTGTACATCCAAGGACCAGGAGAAGTGTGTTTTCGAGTATTCTTCGCTGTCGGCTGCACCGTCTAAAAAATAACCTGCATGCATCGTTCTGGAAGAGCGTGACAGGCAGGAAAGTATTGAATTGCGCTACAACAAAAAAGGCGATCCAAGATCGCCTTTTTTTTGTACAGCGTTTATGCAGCGCTAAACAGCTTATGCGGATCAATCACAAACTTCTTCGGCACACCCGCATCAAACTCGCCATACCCACGCGGCGCGTCATCCAGGCTGATCACCTCAACGCCAACGATGTCCGCAATATGAATACGGTCCCACATGATCGCCTGCATCAGCTGGCGGTTGTACTTCATCACCGGCGTCTGGCCAGTGTGGAAGCTATGGGATTTGGCCCAGCCCAGACCGAAACGAATGCTCAGGCTGCCCATTTTCGCGGCGGCGTCCACTGCACCTGGATCTTCGGTGACGTAGAGGCCAGGAATACCGATCTTGCCGGCCACACGCACCACGCCCATCAACGAGTTGAGCACGGTGGCCGGAGCCTCGTGTTTCACACCGTCATGACCATGACCACGCGCTTCGAAGCCTACGGCATCGACGGCGCAATCCACTTCCGGCTCGCCCAGCAGCGCGGCGATCTGTTCGTGCAGCGGGGTGTCGAGGGACAGGTCGGCGATTTCGAAACCCTGGGCCTTGGCGTGTGCCAGGCGGACGGTGTTGACGTCACCGATGATCACCACGGCCGCGCCCAGCAGGCGAGCGGAAGCGGCGGCCGCCAGGCCAACCGGGCCGGCGCCCGCGATGTACACGGTGCTGCCCGGGCCAACGCCGGCGGTGACGGCGCCGTGGTAACCGGTGGGCAGGATGTCGGAGAGGCAGGTCAGGTCACGGATTTTTTCCATGGCGCGATCGCGATCCGGCAGTTTCAGCAGGTTGAAGTCGGCGTATGGCACCATGGCGTATTCGGCCTGGCCACCGGTCCAGTCGCCCATGTCGACATAGCCGTAGGCACCGCCTGGACGGGCGGGGTTGACGCTGAGGCAGACACCGGTATGCATCTCTTTGCAGGAACGGCAGCGCCCGCAAGCGACGTTGAACGGCACGGAGACCAGGTCGCCGATTTGCAGGTTTTCGACGTCGCTGCCCTTCTCGATCACTTCACCGGTGATTTCGTGACCCAGTACCAGGCCGGTCTGGGCGGTGGTACGACCGCGCACCATGTGCTGGTCGGAACCACAGATGTTGGTTGAAACCACACGCAGGATGACGGCGTGATTGATCTTCCTGCCGCGCGGGTCCTGCATTTTGGGATAGTCGATTTTCTGTATTTCGACCTGGCCATTGCCGAGATACACGACACCACGATTACCAGACATGCTTTCACCTCGCTGTTGTTTTTATGTAGTCGCGTCGCCCGGGATCGGCGGCGCGTTGATTGCTTGGGTTATTGCTTGTGTCTTTTTGCGTTGTTTGTAAGGGCCTCATCGCGAGCAAGCTCGCTCCCACAGTTGATCTTTGGTGTGACTGAGATCTGGGGGCAGACACAAATCCCTGTGGGAGCGAGCTTGCTCGCGATAGCGATCTAAAGAACGACAGTGCGATTAGCGTTCAGGAAAACCCTTCGTTCAATGTGATATCCAACGGCCCGCGCCAATGTCAGCCCTTCGATATCCCGCCCCTTGGCAATCAGATCTTCGGGGTAATGACTGTGATCCACAGCCTCCACGCCCTGGGCGATGATCGGACCTTCGTCCAGGTCGTTGTTGATGTAGTGCGCGGTGGCGCCGACCAGTTTCACGCCCTTGTTGTAGGCCTGGTGATACGGCTTGGCGCCCTTGAAGCCCGGCAGCAGGGAGTGGTGAATGTTGATTGCCTTGCCGTCGAGTTTGCGGCACAGCTCTGGCGACAGGACCTGCATGTAACGAGCAAGAATGACCAGCTCGGCGCCGGACTCTTCGATCACTTGCCAGACCTGGCGCTCCTGGGATGGCTTATCGTTCGGGTCCAGCGGGAAGTGGTAATAGGGAATCTGGTGCCAGTCGGCCAACGGCTTGAGGTCGGGGTGATTGGACACCACGGCGGCCACATCCATGGACAGCTGGCCGATGCGCTGACGGTAGAGCAAGTCGTTGAGGCAGTGGTCGGCCTTGGAGACCATGATCACCACTTTCGGCCGGTAGTTCGGCGCGGTCAGTTCGAAGATCATGCCAAACGCCTGGCCACGTTCTTCAAGGCCTGCGCGGAAGGATTGTTCGTCGAAGCCGTCGGGCTGGCGGAATTCCACGCGAATGAAGAAACGGCCCGAGAGCCGGTCATCGAAGGAGTGGTGTTCGGTGACGTAGCAGCCCTGCTCGAACAGAAAGCGCGTCACCGCATCCACGGTGCCGAGGACGCTTGGGCAATCGGCGGTCAGAATCCATGTGTCTGGGGCGCGGCTCATAGTGCGGTGACTCCTGAGACATCGATAATCGAAACTGCCTCCCCTGTAGGAGCGAGCTTGCTCGCGATGGACGTCAACGATAACGCGTACTTCCTGGAATAACGCGTCGCCTTCAACTCCATCGCGAGCAAGCTCGCTCCTACAGGGAGGCGGCGGTCAGGCCTGGACGCTAAGCCCGAATTCAGCGGACGCATCCTGCAACCACAACCACCAGTAATCCGAGAAGCTGCGACGGATCAGCAGTTCCCAGGTGTCTTCGGCGGTGTGGCGGATCATCAGTTGCGATTTGGCAAACACCGTGCCCACTGCCTTGCCGACCGGAAAGCTGTTGGGGTGCACGTCGTAGCTGGTGGATTTCATCAGCACCTGGCGCACGTTCGGGCCGCTCAGTTCGAGAAGCTGCTGGCCGCCGCTGACGTTGACGATGGCGATATGCAGATCGCCCAGCGCTTTACGCAGTTTTTGCTCGGCAGCGAATTCTTCGCCGCTCGGGACGATCAGCAACCATTCATCCGGCCCCATCCATTGCAGGCTGGTTTCGCCTTTGACGATGACGGTCAGCGCGCCTGGCAATTCGATGCCCAGCGCTTTTTGCACGCCAGCGGCGAAGGCTGCATCGTGGCCATCGCCACGAATGGTCAGGTGGCCGAGCAGTTTTTTCTCGCGCACGATCACGCCGGCGCTTTTACGGCCCTTGCCCACCAGGCTGGCGAGGTCGGCATGATGCAGCGACGACTCGGCCTTGGCCCCGGTGGTTGGGCGTTGTTGGTACACATTGGCTGCGGTCATAAAACACCTTTCCTGAATTCGTACGACACACCGTAGGAGCGAGGCTCGCCCGCGAAGGCAGCGACGCGGTTTATCTGAGGGACCGCGTTATCGTTCTTCGCGGGCAAGCCTCGCTCCTACGGGAGCTGTGGTGTTACACGTTCTGGCGATCGCCTTTCGGATCGAAGAACACCGAAGAAACGATTTCCGCCTCGATCACGCTGCCGTCGGCCAGCGGTGCGAACACGCGCTCACCGATGCGCTTCAAGCCGCCCTTGACCACACCCATGGCAAACGAATAGCCGAGGGAGTTGTGCAGGTAACTGGAAGTCACGTGACCAACCATGGTCATCGGGATGGTTTGCTTGGTGTTGAACACCAACTGCGCACCCTCTGGCAGCCATTTGGTCGGATCGATCGGCTTCAGGCCCACCAGCTGCTTGCGCTGATCACGCACGCAGTCTTCGCGGTTCATGCCACGCCAGCCAATCCACGAGAACGGTTTGGTGCGACCGACACACCAGCCCATGTTCAGGTCGTCCGGGGTCATCGAGCTGTCAGTGTCCTGACCGACGATGATGAAGCCCTTCTCGGCCCGCAGCACGTGCATGGTTTCGGTGCCGTACGGGGTCAGGTTGTACTTCTTGCCAGCATCGACAATTTTTTCCAGCACGCCCATGGCGTAGTCGGCTTGCACGTTGACTTCGTACGACAGCTCACCGGTAAACGAAATCCGGAATACCCGCGCCGGCACACCGCCGACCAGGCCTTCTTTCCAGGTCATGAACGGGAAGGCTTCGTTGCTGATATCGATGTCGGTGACTTCGCCCAGCAGCTTGCGGCTGTTCGGGCCGGACAGGGTCATGGTTGCCCAGTGGTCCGTCACGGACGTGAAGTACACCTTCAAGTCTGGCCATTCGGTCTGGTGGTAGATTTCCAGCCATTGCAGCACGCGCGCAGCGCCGCCGGTGGTGGTGGTCATCACGAAATGGTTGTCGGCCAGGCATGCAGTCACGCCGTCGTCGAACACCATGCCGTCTTCTTTGCACATCAGGCCGTAGCGGGCCTTGCCCACGTCGAGCTTGGTCCAGGCATTGGTGTAGATGCGGTTGAGAAACTCGCGGGAGTCCGGGCCCTGGATGTCGATCTTGCCCAGGGTCGAAGCGTCCAGCAGGCCGACGCTGTCGCGCACGGCTTTGCATTCGCGCTTGACCGCGGCGTGCAGGTCTTCACCGTTTTTCGGGAAGTACCATGGACGTTTCCACTGACCGACGTCTTCGAACTCGGCGCCATTCTTCACGTGCCAGTGATGCAGCGCAGTGAAGCGTACCGGCTCGAAGATGTGCCCACAGTGACGACCGGCCACGGCGCCGAAGGTCACCGGCGTGTAGTTCGGACGGAACATGGTGGTGCCCATCTGCGGGATGGTCACGTTCAGCGAACGGGCGGCGATGGCCAGGCCGTTGACGTTGCCCAGCTTGCCCTGGTCGGTACCGAAGCCCAGTGCGGTGTAGCGTTTGACGTGCTCGACCGATTCGAAGCCTTCGCGGGTCGCCAGTTCGATGCCGCCAGCGGTGACGTCGTTCTGGAAGTCGACGAATTGCTTCGGCGCTCGTGCAGAGTTCTTTTCGTGAGGCACCTGGAACAGCGCCAGCGTCGGTTCTTCGACACGGCTCAGGGCTTTGGGCAAGGTGCCTTCGACCCCACTGAAGCCGGCTTCGCTGGCCGCGCGGGCGCCACCTTCGAAACCATCGGCCAGGGAATCGCCGAGACCGTAGACGCCGTTGATGCCACCGACACATACGCGTTTCTGCGGTGCTTCGCCCGGTACGAAACCGAGGATATCGTCGCGCCAGATCGGCTTGCCGCCCAAGTGCGAGGCCAGGTGAACCACCGGGCTGTAACCGCCGGAGCTGGCGACCAGGTCGCATTCGAGCCATTCACCCGGGCTGGTCACGGCGTGCGCCTTGACGTCGATCGCGGCAACGCGGGCAGCGGTCACGCGCTTGCTGCCGCGGGCCTCGATCACGGCGCTGCCGGTCAGGATGCGGATGCCTTTGGCGCGCGCTTCTTCAACCAGCGCACCGCGCGGATTGCTGCGAGCGTCGGCGATGGCCACCACTTGCAGGCTGGCGTCGAGCCAGTCCAGGGCAACGCGGTAGGCGTGGTCGTTGTTGGTCGACAGCACCAGTTTTTTGCCTGGCGCCACGCCGTAACGGCGCACGTAAGTCGACACCGCGCCGGCGAGCATGTTGCCCGGCACGTCGTTGTTGCCGTAAACCAGTGGACGCTCGTGAGTGCCGGTCGCCAGCACCACACGCTTGGCGCGAACCCGGTGGATGCGCTGACGCACCTGGCCAATCGGTGCGCGGTCGCCGAGGTGATCGGTCAGGCGCTCGTGAATGGTCAGGAAGTTGTGGTCGTGGTAACCGTTGACCGTGGCGCGCGGCAACAGCAGCACGTCCGGGGTATTTTTCAATTCGTCGATGACGCTGGCGACCCACTCGATAGCAGGCTTGCCGTCGAGGCTTTCACGGGAATCGAGCAGGCTGCCGCCGAACTCTTCCTGCTCATCGGCCAGGATCACACGCGCACCGCTGCGGGCAGCCGCCAGTGCAGCCGCCAGACCCGCAGGGCCAGCGCCGACGATCAGCACGTCGCAGTGCTGGTTCATGTAGTCGTAGGTGTCCGGATCGTTCTCGGTCGGCGAACGGCCTAAACCTGCGGCCTTACGAATGTACTTCTCGTAGGTCATCCAGAACGATTGCGGGTACATGAAGGTTTTGTAGTAGAAGCCCGGCGGCATCAGCTTGCCGCCGACCTTGCCGAGAATCCCCATCATATCGTTGTTCACGCTTGGCCAGCCGTTGGTGCTGGTGGCGACCAGGCCTTGGTACAGCGCCTGTTGCGTGGCGCGCACGTTTGGAATCTGGGTGGCTTCGGTGGCGCCGATCTGCAGCACCGCGTTCGGCTCTTCGGCACCGGCGGCGAAGATGCCGCGCGGACGCGAATACTTGAAGCTGCGACCGATGATGTCCACACCGTTGGCGATCAGGGCGGCCGCCAGGGAGTCGCCTTCAAAGCCTTTGTAGCTCTGGCCGTTGAACGTGAAGCTCAGCACTTTGTTGCGGTCGATCCGTCCGCCGTTGGACAGGCGATTGATCTGGCTCATACCTTCTCTCCCAGAGCCGTGGCGGCCGCTTTCGGGCTGTCGGTCTTGTCGGTGAATTGTGGCTTGGTGCCGATCTTGTAGGTTTCGAGAATCTCGTAGGTCACGGTGTCGCGCGTCACGTTGAAATACTGACGGCAGCCGGCGACGTGATCCCACAGTTCGTGGTGCAGACCGCGAGGGTTATCGCGGAAGAACATGTAGTCGCCCCACTCCTCGTCGGTGCAGCTATTCGGATCCAGTGGACGCGGGATATGCGCCTGGCCGGATGCGTGGAATTCCTCTTCGGAGCGCAGTTCGCCACAGTGAGGACAGAAGATATGCAACATAGGGATTTCTCCTGTTAGTGGGCGACTGCTGCAGCGCCGTGTTCGTCGATCAACGCACCGTTGTGGAAACGGTCGATGGAGAAAGGTGCGGCCAACGGGTGCATTTCACCCTTGGCCAGGCTTGCGGCAAATACGTTGCCCGAGCCAGGTGTGGCCTTGAAGCCACCGGTGCCCCAACCGCAGTTGAAGAACATGTTCGGTACCGGCGTCTTGGAGATGATCGGGCACGCATCCGGCGTGGTGTCGACGATGCCGCCCCACTGACGGTTCATGCGTACGCGCGACAGCACCGGGAACATTTCGACGATGGCCTGGACGGTGTGCTCGATCACCGGGTACGAACCCCGCTGGCCATAGCCGTTGTAGCCGTCGATACCGGCGCCGATCACCAGGTCGCCCTTGTCGGACTGGCTGATGTAACCGTGTACGGCGTTGGACATGATCACGCTGTCGATAATCGGCTTGATCGGCTCGGACACCAGCGCTTGCAGCGGGTGGGATTCGATCGGCAGGCGGAAACCGGCGAGCTTGGCCATGTGCCCGGAATTACCGGCGGTGACCACGCCGACGCGCTTGCCGCCGATGAAGCCCTTGTTGGTTTCAACGCCGATGCACACGCCGTTTTCCTTGCGGAAGCCGATCACTTCGGTCTGCTGGATCAGGTCCACGCCCAAGGCGTCAGCGGCACGGGCAAAACCCCAGGCCACGGCATCGTGACGGGCCACGCCGCCGCGACGCTGGACGGTGGCGCCCATCACCGGGTAGCGGGTGTTCTTCGAGCAGTCGAGATACGGAATCTCGTCGGCCACTTGCTTGGCATCGAGCAGCTCGCCGTCCACGCCGTTGAGGCGGTTGGCGCTGACCCGACGCTCGGAATCACGGATGTCCTGCAGGGTGTGGCACAGGTTGTAGACGCCGCGCTGGGAGAACATCACGTTGTAGTTCAGGTCCTGGGACAGGCCTTCCCACAATTTCATTGCGTGTTCGTACAGGTGCGCCGACTCGTCCCACAGGTAGTTGGAGCGAACGATGGTGGTGTTGCGCGCGGTGTTACCGCCGCCCAGCCAGCCTTTCTCGACCACGGCCACGTTGGTGATGCCATGCTCTTTTGCCAGGTAGTAGGCGGTCGCCAGACCATGCCCGCCACCGCCGACGATGACCACGTCATAGACCTTTTTCGGGGTCGGCGTGCGCCACATCCGCTGCCAGTTTTCGTGGTGGCTGAGGGAGTGTTTGAAGAGGCCGAAGCCTGAGTAGCGTTGCATAGTCATTTACTCCAAAACCGCGCTCAGCGATAAACCGGGAAGTCCGCGCACAGTGCCGACACTTGCTGGGCGACATTCGCTTCGACATCGGCGTCGCCGAGGTTGTCGAGGATGTCGCAGATCCAGCCGGCCAGTTCCACGCACTGGGTCACCTTGAAGCCGCGGGTGGTTACCGCCGGGGTGCCGATACGCAGGCCGGAGGTGACGAACGGCGACTGTGGATCGTTCGGGACAGCGTTCTTGTTCACGGTGATGTGGGCGCGACCGAGTGCTGCGTCCGCCTCTTTGCCGGTGAGGCCCTGACGGATCAGGCTGACCAGGAACAGGTGGTTATCGGTACCGCCGGACACTACATCGTAGCCGCGTTTGATAAATACGCCGGCCATGGCCTGGGCGTTGTCGATCACTTGTTGCTGATAGGCCTTGAAACCTGGCTCCAGCGCTTCCTTGAAGCAGACCGCTTTACCAGCGATCACGTGCATCAGCGGGCCGCCCTGGGCACCCGGGAAGACTGCCGCGTTGAGCTTCTTCTCGATTTCTTCGTTGGACTTGCACAGGATCAGGCCGCCACGCGGACCGCGCAGGGTCTTGTGGGTAGTGGTAGTGACCACATCGGCGTATGGCAGCGGATTCGGGTACAGACCTGCAGCGACCAGACCGGCGACGTGAGCCATGTCGACGAACAGCAGGGCACCGACCTTGTCGGCGATCTGACGGAAGCGTGGGAAATCCAGAGTCTTGGAGTAGGCAGAGAAGCCGGCAACGATCATCTTCGGCTTGCACTCAACGGCCAGGCGCTCGACTTCGTCGTAGTCGATCAGGCCGGTCTTGGTGTCGATGCCGTACTGCACGGCGTTGTACAGCTTGCCCGAGGACGACACTTTGGCGCCGTGGGTCAAGTGACCGCCGTGGGCCAGGCTCATGCCCAGAATGGTGTCGCCGGCTTGCAGCAGGGCCAGGTAAACGGCGCTGTTGGCCGAGGAACCGGAGTGCGGTTGCACGTTGGCGTAGTCGGCACCGAACAGTTGCTTGGCGCGTTCGATGGCCAGCGCTTCGACTTTATCGACGTGCTCGCAGCCACCGTAGTAGCGCTTGCCCGGATAGCCTTCGGCGTATTTGTTGGTCAGGCCACTGCCTTGCGCTTCCATGACGCGTTTGCTGGTGTAGTTCTCTGACGCGATCAGCTCGATGTGATCTTCCTGGCGTTGTTCCTCGGCATTCATCGCCGCCAGCAGTGCATCGTCGTAGCCTTTGATCTGGTCTTGCTTGCTGAACATCGCGTCTCTCCCAGCGGCGGTGGTGCGCCATTCGTCTCGGTGAGGCACTGGCGTTTCGGCAGTGCCCTTTGAATGCGATGGTATGACCGGCGCAGACAGGCCAAATGCCTACGGACGCCACGCAAAGGTGCGTTTACGACATGGCCTGAAATGGCAAGTCGAACACGATCTCCAAATCAACAGAGAACCCTGTGGGAGCGGGCTTGCTCGCGATAGCGGTGGGTCAGCCGCCATCATTGCTGGATGTGATGCCGCCATCGCGGGCAAGCCCGCTCCCACAGGGTTATGCGGCGAGCTTGCGGATGAGTAGCAGCAGTAAGAAATGCAGTGGATATAAGGCATACGCCCAGCGCCGCATCGGCGGCAGCTTGAAATGCCCGGCATGTCGCAACAAGACCATCCCCAGCAATGGCGCGATCAGACAAACGGCGATGCCGAGGATGGCTGCGCGGTTGCCGAACCGGGCCGAGTAATACAGCACCTCCCATTGATTGGCCGCCAGGCAGATCAATCCCGGTAACAGGTTGAAATACCAGGGCCGCCTGATCACCAGCAACGTCACCAACGGCAACAACACCCCGAAAAAACCGAACATCAGTCGCTCCGGGAACAGTGCCGCCAACACCAACGCAGCGGCCGCCAGCAGTCGCGATTGCAGCAGCGGTTGCTGCCAGCCCCGCGCCACCAACAGGCCCAGGGCCAGCGTGGGCAGCACATTGAAGGTGTCGGGGTCAGGAATGAACATTCTGTAGGGCATTTCACTGACGGCGCTAAACAGCAACAACCACCCCAGATACCGCCAATGGCCGTCGGTCGTGACGCTTCGGGCGCGCGACAGATTGGCCGCCATCGCCAGACAGAACCACGGGAACGCCAGGCGCCCCGGCACATACAGGATATCGACGGAATAACCGATATATCGCAGATGATCGAGCACCATGCTCAATAGTGCCAGCCACTTCAGCAGATCCAGTGCACCGTCCCGTTGAGTCATGTGCATAATTGCCCTGTATTTTTCTGACAGAAAGATCCCGTGCGCTCCCCGGACGACCTTCGGTAGAGTGCGCACCATCATTGACCACGATGCTCTTCACCATAAGAGTCTCGATCACGGAAGCCGGCCATGACCGACAAGAGCCAACAATTCGCCAGCGACAACTATTCCGGTATCTGCCCTGAAGCCTGGGCGGCCATGGAACAGGCCAACCACGGCCACCAGCGCGCGTATGGCGACGATGAATGGACCGCCCGCGCGGCTGATCAATTCCGCAAACTGTTCGAAACCGACTGCGAAGTGTTTTTCGCCTTCAACGGCACCGCCGCCAACTCCCTGGCCCTGTCGTCGCTGTGCCAGAGTTACCACAGCGTGATCTGCTCGGAAACCGCCCACGTCGAAACCGACGAATGCGGCGCGCCGGAGTTCTTTTCCAACGGTTCCAAATTGCTCGTCGCCCGCACCGAAAACGGCAAGCTGACCCCGGAATCGATCCGCGAAATCGCCCTCAAGCGCCAGGACATTCACTACCCGAAACCGCGCGTCGTGACCCTGACCCAGGCCACTGAAGTCGGCAGCGTCTACACCCCCGAAGAAATCCGCGCCATCAGCGTCACCTGTAAGGAACTGGGCCTGAACCTGCACATGGACGGCGCGCGCTTCTCCAATGCCTGCGCATTCCTTGGCTGCTCACCCGCCGACCTGACCTGGAAGGCCGGTGTCGACGTGTTGTGCTTTGGCGGTACGAAAAACGGCATGGCGGTCGGCGAGGCCATCCTGTTCTTCAATCACAAACTGGCCGAAGACTTTGACTACCGCTGCAAACAGGCAGGCCAGCTGGCTTCCAAAATGCGCTTCCTGTCCGCCCCGTGGGTCGGGATCCTGGAAAACGACGCCTGGCTAAACTACGCCCGCCACGCCAACCACTGCGCCCAATTGTTGGCGGAACTGGTCAGCGACATTCCGGGAGTGGAACTGATGTTCCCGGTGCAGGCCAACGGCGTATTCCTGCAACTCTCGGAACCGGCGATCGCCGCATTGACCGCCAAGGGCTGGCGCTTCTACACCTTCATCGGCAACGGCGGCGCCCGCTTCATGTGCTCGTGGGACACCGAAGAAGAGCGTGTGCGGGAACTGGCGACGGATATTCGTGAAGTGATGGCCCGCTAACCCTCGTTCACGACACACACCCTGTGTACCGATGGTTGTGGAAACGCCAAACCCTGTGGGAGCCGGCTTGCCGGCGAAGGCGTCTTCAAGGGCCCTGCAAGGCTCAAGACCTTTCGCTGCGGTGCGGCGAGCCGACAAGCCAGCTCCGACAATCCTCATTACAAACATGCATGCGTTCAGCCAGCAGACTTCGTCTACATTGACTGGCGAGCCGATAACACTCAGGAGCGCATGCATGTCATTACAAGGAAAAACCCTGTTCATTACCGGCGCCAGCCGCGGCATCGGGCGCGAGATTGCGCTGCGGGCCGCACGGGACGGGGCCAATATTGTGATTGCGGCCAAAAGCGCCGAGCCGCACCCCAAGTTGCCGGGCACGATTTTCAGCGTGGCGAAGGAAGTCGAAGCCGCTGGCGGTAAAGCGCTGGCCTTGCAGGTGGATGTGCGTGACGAGGTCGCGGTACATGAAGCACTGGCCAGGGCCAACGAGCATTTCGGTGGCATCGATGCGCTGGTCAACAACGCCGGGGCGATCAAGCTGACCGGCGTGCAACACATCGAACTCAAGCGCTTCGACCTGATGCACCAGATCAACACCCGCGCCGTACTGCTATGCAGCCAGGCTGCCCTGCCCTACCTGAAAAAGAGCAGCGGCCATATCCTCAACCTGTCGCCGCCACTGAACCTGGCGAGCAAATGGTTCGCCCAGTACAGCCCCTACACCGTGACCAAATACGGCATGAGCATGCTGACCGTCGGCATGAGCGAGGAATTCAAGCACTACGGCATCAGCGTCAACTCGCTGTGGCCGCAGACCATGATCGCCACCGCCGCCATCGAGTTTCAGCTGGGTTCCCGGGAGTCGTTCAAGCATGCGCGTACGCCGGCGATCATGGCGGATGCTGCGCACGTGATTCTGGACAGCAGCGAGCGCAGCATTACGGGGCGCTTGCTGATTGATGAGGAGATTCTGCGTGAGCATGGCGTGACCGAATTTGATCACTACCGCTTCGAGCCCGGCACCAACGACAAGCTGATGCCCGACTTGTTTATCGATTGAAAAACGGTCAGTCATGACACCGCTGAACCTGTGGGAGCGAGCTTGCTCGCGATGACGGCGGTACATTCAACATCTATGTTGGCTGACCTACCGCTATCGCGAGCAAGCTCGCTCCCACAGGTTTCGCAGTGTTGATCAAAACTCGATCCGCACATCGCCCTTCGGCACGCTGCAGCACGACAGGATGAACCCCTCGGCTTCGTCTTCCTCGGTGATCCCGCCGTTGTGGTCCATGTCGACCTCGCCACCCAGTTTCAACACCTTGCACGTCCCGCAGATCCCCATCCCGCACGCTTTCGGAATCAACAGGCCCAACTTGGCGGCAGCGGCGTGAACGGTTTCCCCCGGTGCAACACGAATGCTCTTGCCGGACGCCGTGAACTCCACCTGATGCAGGTCCGCCACGTCGATGTCCGGTGCGTCTGCGGCAATTTCGGCTTGCTCCACCGCATCGGCGCGGGCTTCCGGTGGCGTGGCGCCGAAAGATTCCTCGTGATAACGCGACATGTCGAAGCCGATCATTTCCAGCATGCGCTTCACCGCATTCATGTACGGCGTCGGGCCGCAGCAGAACACTTCGCGCTCCATGAAGTCCGGCGCCATCAACTCGAGCATCTTCTGGTTCAGGTAACCGCGATAACCGGCCCATGGTTCACCCAGGCCATGCTTCTCGCAGATCAGGTGCAGGCTGAAGTTGTCGATCCGCGACGCCATGTGTTCCAGCTCGCGGTGGTAAATGATGTCTTTGGGCGAACGGGCGCTGTGGATAAACACCATGTCGACGTTGCCGTTGGTGTCGTAGAACCAGCGCGCCATGGACATGACCGGCGTGATGCCAACGCCGCCGCTGAGGTACAGCACTTTCGGCGCGGTGAAGTCCATGGCGTTGAACAGCCCGACCGGTCCGTGCACCGCCAATTCCTGGCCTTCGTGCAGGGTGTCGTGCAACCAGTTGGAAACCTTGCCGCCCGGCACGCGCTTGATGGTCACCGAAAAGCTGTACGGCACCGACGGCGAGCTGGAAATGGTGTAGGAGCGCATGATCGGCACGCCTTCGATTTCCAGCTCCAGGGTGACAAACTGCCCGGGCTTGAAAAAGAACAGGATCGGCTGGTCGGCCATGAAGCAGAAGGTGCGCACATCCCAGGTTTCCTGGATGACTTTGACGCAACGGACGATATGTCGGCCATTGGCCCAGGTCTGGGTGGTTACCGGATTCAGGAAGCTGTTGGACATGCTGTTCTCCACCGCCGATGGTCGGCCTTATGTTGGCGATTCTGCGTATACCGCGAACCACCCATTTACCTATCTGCGACATTCACATACTTATCGCGACCAGCCCCCAACTACCGGGGGTTGCGCGTCGGGAACAGATTGGGCCATGTCGCCCATGGATAAGGTTCCCGGCAGCGCCGGCCCCACACTCGCCACAACAGATAAATGCTGTTTGTGTCTTGCGTAGCAACCGTATCAGCCACTATTCGCCGGCCACACAGAATGGCCATGAGGATCAAAACGATGGACGTCACCGCAAAAATCAGCCTGGGCGATCCGCTGGAACCCGCACGCAAGGCCACCGCGCAGATGCTGCAAGAGCGCGAGCGCACTTTCTCGCTGCCGCAGCCGTTTTACTCTGACGAGCGGCTGTTTGATATCGACATGCAGGAAATCTTCCAGAAAGAATGGTTGATCGCCGGCATGACCTGCGAGATCCCGACCAAGGGCAACTACCTGACCCTGCAGATCGGCAAGAACCCGATCATCGTGATCCGCGGCGCCGAAGGTGTGGTGCATGCGTTCCACAACGTCTGTCGTCACCGTGGTTCGCGGCTGTGCACCAGTGAAAAAGGCAAGGTCGCCAAGCTGGTCTGCCACTACCACCAGTGGACTTACGAGCTGGACGGTCGCCTGCTGTTCGCCGGCACCGAAATGGGCGCCGACTTCGACATGAAGCAATACGGCCTCAAACCGGTGAACGTGAAGACCGCCGGCGGCTATATCTTCATCAGCCTGTCGGAGAACCCGCCAGCCATCGATGACTTCCTGGCGACGTTGAACCATTACATGGAACCGTACGACATGGAGAACACCAAGGTGGCGATTACCACCACCTTGATGGAAAAGGCCAACTGGAAGCTGGTGCTGGAGAACAACCGCGAGTGCTACCACTGCAACGCCTCGCACCCGGAACTGCTGAAAACCCTGCTGGAATGGGACGACGTCACCGACCCGCGGGCCGACCAGGCGTTCAAGGACCACGTCGCCGCCTCCGCCGCCGCCTGGGAAGCCGAAAAAATTCCTTACGCCCACGCCAGCTTCGGCCTGCGTAACCGTATCGTGCGCATGCCGCTGCTCAAGGGCACCGTGTCGATGACCTTGGACGGCAAGCAGGGTTGCGCCAAACTCATGGGTCGCATCAAGAACCCGGACCTGGGCTCGATGCGTATCCTGCACCTGCCGCACTCCTGGAACCACTGCATGGGCGACCACATCATCGTCTTCACGGTGTGGCCGATCAGCGCCCAGGAAACCATGGTCACCACCAAGTGGGTCGTGCACAAGGACGCGGTCGAAGGCGTGGACTACGACGTGGAGCGCATGCGCCAGGTCTGGGATGCGACCAACGACCAGGACCGTCGCCTGGCCGAAGAGAACCAGCGCGGGATCAACTCCACGGCGTACCAGCCCGGGCCTTATTCCAAGACCTATGAGTTCGGTGTGGTGAACTTTGTGGACTGGTATAGCGAGCGGTTGTTGAACAATCTTGGGGCTGAGCCTGCGCCTTACCTCAAAGGCGTCCCGGTTCAGGGCTAACAGCAAAAGCATCGCGGGCAAGCCCGCTCCCACAGGGGATTGGTGGTGTTCAAAAATACTGCGAACAACATCAATCACTGTGGGAGCGAGCTTGCTCGCGATGGGGCCCTCACATTCACCTCATCAGCTTGAAGACCACCGCACCGACCCATCCTCTCCAATAAACTCCTCAAAACGCTCACCCCCCACCCACCGCACCTTCACATAATCATTCAACACCCGATCCGGGTAGGTTGAGGTTATCCATCGCGCGCGCTCCCTGAACCGATGTGGATTATTGACGGCTGTCCTTGTGCCGCGTGAGCGAACAGGTGACCGGCTGAAGTCAACACATGCCTTATAACTGTATGAAATCTGATCTATTGCGTTCAGGCCTATGCGGAACGTGGCTTGCAGGGTTTGGCGAACAAGTTATCCACAACTCCACCCACAGCTAATGGGGACAAGTGTGCAATCGGTGGAAATTTTATTCACAAAATGCGAAGAAAATCCGTGACTTATCCGGAATCAGGGTTCCTGGCGACAATTGGCTATTTTTTGATCTAAAGCTTGTAAGCCACGTTTTACCTGGCCCCCAGAGGATGGCGAACACCTTATCCACAGAAGCGCCAACAGACTTTGGGGGCAACTATGGCCGCTCTGTGGAAAACCACGGAAACCCGCGATAAATCGGGGTTTTAGGAAGGTATTCCACAATAATACGCTGATTTGACTGTTTTTTAACCAGACCCCTGATAGGCCCGTTTTATATGGCCTGCAGCCGACAGCAAACATCTTATCCACAGAAGCGCCAACAGAGATTGGGGGCAAGTATGGGTCCGCCAGTAAACTTATCCTCTGGAAAAAGCTCGAGAAAACCGTGAGTTAGGCTGGTTGTTTTTTGTACGAAGGCTTGCAGGGCTTGTTTTACATGGGGTGCAGCGAGGGGCGAACATGTTATCCACAGAAGCGCTAACAGGGATTGTGGGTAAATGATAAACCCTGTAGGAGCTGGCTTGCCAGCGAAGAGGCCGTAACATTCAACATCTATTTTGACTGTTACGCCGCCTTCGCTGGCAAGCCAGCTCCTACAGGGTTGTGGGTAACGGCTACGGACGGTACATCAGATACGCCTCACCCGTGACCCGAATCATCGGGTGCGGCGTGATCTGACAGGTGTCGACGATGCGGAAGCCATTGCGCTCGTAAAACCGGCGGGCGCCGGTGTTTGCGGCGTAGTCGATCAGGCTCAAGCCGTTGAGGCCCAACTGGTTGGCGCGGTCGTAAGCATAGGCAAGGAATTGCTTGCCCAAGCCCTGGTTGCGCCAGCCTTCATGCAAAGCCAGGCTGGAAATGTAGAGGGTGTCGGGGATTTCCATCGTCGCGTAGGGCGCCAGCACCGGGTCGGTTGTCGGCTCTGCCAGCGGATCGTGACGCATCACATAGCTGTGCATCATGCCAATGACCTCGTCATTCGCCTGTGCGATAAGGCAGTTCTGCCAGGAGAAGTCTACGTCGTCACGGGCATATCGGGTGGCGCCGACGTCCAGCAGATCCTGGCCGGGCTGTGCCAGTTGACTCCAGATGTAATCCGCAGCCCCCTCCGATGTGATTTGAAACAAACGCGCAATTTCCCGCGCGTCCGCACGCACTGCCGAACGAAACTCAACTGTCATTGTTTCCCCATAAATGTCGGTGACCAAACATCCTGTGGGAGCGGGCTTGCTCCGGGCGGCGTTCCGACGAACGCGGCGTGTCAGGCAATCAAATGTCGACTGACTCACTGCATTCGTCGGAACGCCGCCCGGAGCAAGCCCGCTCCCACAATGGACTAGCGGTGGATTTGTTTTAGCGGACCACGCCTTCTTCGATCAGCAATTTGAGAATGGCTTCGGCGCCTGCTTGCGCCGTGACGCCTTTGAGCACCTGACCACCGCCGCCACTGGCCTTGGCCGTGGCCGCCTTCATCCGGTCCGCGCCGCTCTTGGCCTTGATCACCTTCAAGCGCTTGGGCCGTGGCTTGGCCGGTTGCAGCGTCGCAACAGCCAGCAACTCGTCATCGACCACTTCAACTTCATCCGCCTGCAGCACTCCCCGCCGAGCCGGGCCGTAGGCGCTCTGCCGAGCCTTCGGCGCGGCGTTATCCACAGTCGCGAGAAACGGCAAGCGCACTTTCAACCGACGGCGCTGCCCCCGAGGCAAGGCTTGCAGCACCAAGGCCGAGCTGCCGTCGATGGATTCAACCTGGGCCAGCCCCACTACCAGCGGCCAGCCAAGACTTTCGGCCAGCAGGAACGGCAGCATGCCCGAGCCTTCGCCGGTTTCCGCCTGGCTGCCGGTCAATACGACCTGCGCGCCGGCGTCACGCAAATAGGCGGTCAAAGCGGGCAGCGCATCGGCGCCGACCGGTTGTTCCAGCACATGCAGCTGTTCCAGGCCCATGCCCAGATAAGCCCGCAACGCCGGTTCCGCAACGTCGCCGGCATGCAGCACTTGCAGGTTATCCCCAGCCAGTTGCAACCCCAGTTCCACCGCCCGCGCATCCTGCTCCGCGCGACGTGGCCGGCCGGAGGTCGGGTGGGCGCCGATGGACACCAGGCTGATGATTTTCGTGCTCATAACCCTTTCCTTCCCTTAAGCCGCATCGCGCTTGGCTTCGTTGCGGTAAGCCTCTACCGCCGCGATCAAGGCTTGAAGTATCTCGGCGCTCTCGCCGATCACCGACAGGTCGGCCCGTTTGATCATGTCGCAACCCGGGTCGAGGTTGATCGCCACCACCTTGTCGCAGGCACCGATGCCTTGCAGATGCTGGATCGCCCCGGAAATCCCCACGGCCACGTAGACCCGAGCGGTGACCCAGGTGCCGGACGCACCGACCTGACGGTCGCGGGCCATGAAGCCATCGTCCACCGCCACTCGAGAGGCGCCTTCGGTCGCGCCCAACGCTTCGGCGGTACTGTGGAAAAGTGCCCAGTCCTTGACCCCGTTACCACCGGAGAAGATGAACTCCGCTTCTGCCATCGGAATCGCCGCCGGATCCACCGCCACCGCGCCCAAATCTTCAATACGCGACAGGCTGCGAGCCACGGTTGTGGATAACTCCACCGGCAACGCCTCGTGACGGGTTTCGCTGACCGGTTCGGCGCATTCGACGGCAGCCAGAATCAAGCGCGCCACCGGGCGTGCCAAATCCTGCAGACCGGCACCGGCACGACCGATGCACGCCTCATCCTTGACCTGCCAGACCCGCGTCGCCGGGCGTTCGCCCAGTGCGGCCGCAAAGCGTCGACCCAATTCGCCGCCACCGGTGCGGCTGTCAGGCAGCAGCCAGTGACGCGGGCTGAACTGGTTATCCACAGCCCGCAGGCCCTGCACCCGTTGTTCCGGTGCATAACCGCTGAACTCTTCGCCATCGAGCACCAGCAAGCGATCGACGCCCGCGGTGGCGAAGGCATTTTCCTTGTGTTCACCGAAGACCACGGCCAACACCGCGCCGTCCTTGCCGGCCAGTTGATGCGCCAGGCCGAGCAGGTCGCGGTCGTGGCTGCTCAAGCGGCCACCGACCATGTCCGGCACCACGCTGATGTAGAACGCCGGTGCAGGCACCTGATGCAACGGCAATTGCACTTCAACCGCGGCCGAGCGTTTACTCGCTCCGCCCTGCTGGGCGCCGCTGCGGTCGATGCGCTTGATGCCGTTGGGACCGATGAAACCGATGCCATGGGGGTTCTTGCGGATGACGCCATTAGGTCCCATCCAGCTGTGTTGCACCGGTTGCATCGCCGCATGCAGCGGATGCAGACGGTTGCGGGCGATCCATTCGGCGCGTGGATCACGGCGGATAATGTCGCTCATCAGTGGGCCTCCGCAGGTTCTTCACGTTTGGCCGGCGCATTGGGTTTGCTCGGGGCAGCGTCTTCGAGCAAAGCGTCCGCGACCAATTCGGCGATGTCCTTGATCAGCGGACGGGGTTCGACCACGCCTTCGAGCATCGCGGTGCATTGTGGACAACCCACGGCCACCAGTTCGGCGCCGGTTTCGCGGATGTCTTCCATGCGCATGTCGGGGATCCGTTGCTTGCCCGGAATGTCGGTGATCGGCGCGCCGCCACCACCGCCGCAGCAGCGGGAGCGGAAACCGGAGCGTTGCATCTCTTTCACTTCAATCCCGAGGGCGCGCAGCACTTCACGCGGTGCCTCGTATTCGCCGTTGTAGCGACCGAGGTAGCACGGGTCGTGATACGTCACGCTGCTGCCTTTGTGCTGGCCGAGGTTCAGGGCGCCAGCGCCGATGATTTCCGCCATATAGGTGCTGTGGTGCTGCACGAGGTAGTTGCCGTCGAAGGCGCCGTACTCGTTTTTCAGCACGTGGAAGCTGTGCGGGTCGCAGGTGACGATGCGGTTGAAGCTGTATTTGGCCAAGGTCTGGATGTTGCGTTTGGCCAACAGCTGGAAGGTCGCTTCGTCGCCCAGGCGTCGGGCCACGTCACCGCTGTCGCGCTCTTCGAGCCCCAGTACCGCGAAGTCGACCTTGGCCGCTTTCAGCACTTTGACGAAGGCGCGCAAGGTGCGCTGGTTGCGCATGTCGAAGGCGCCGTCGCCGACCCAGAACAGCACGTCGACCGACTTCTTCTCGCTGAGCAGGTCCAGGTTCAAGTCCGCCGCCCAGTTCATCCGCCCGCCCGGGGCGAAGCCGCCAGGGTTGTCGGTGGCGATCAGGTTCTCCAGGACTTCGGCGCCCTTGTTCGGGGTCGCGCCTTTTTCCAGGGTCAGATGGCGGCGCATGTCGACGATGGCATCGACGTGCTCGATCATCATCGGGCACTCCTCGACGCAGGCGCGGCAGGTGGTGCAGGACCACAGGGTTTCGGCGTCCACCAGACCGTTGACGATCGGTTGATGCGGGTTACCGGCGTGCTCGCCGATGGGTTTGCCTGGATAAGGGCTGCCGGCGAACTTGGCATCGGTGCCACCGGCCAGGCCGACCACCATGTCCTGGATCAGTTTTTTCGGGTTCAGCGGCTGGCCGGCGGCGAATGCCGGGCACGCGGCTTCGCATTTACCGCACTGCACACAGGCGTCGAAGCCGAGCAATTGGTTCCAGGTGAAATCCTTGGGTTTTTCCACGCCCAGCGGCGCGTTCGGGTCATTCAGATCCAGCGGCTTCAAACCGGTGGAACGACCCCCGCCAAAACGCTCGGCGCGACGGTGCCAGGCCAGGTGCAATGCGCCAGCGAAGGCGTGCTTCATCGGCCCGCCCCAGGTCATGCCGAAGAATAGTTCCGAGACGCCCCACAGCACACCGACACCGAGGATCGCCGCCACTACCCAGCCGCCGAAGTTTTCCGGAAGGATACCGGCGACCGGCAGGGTCAACAGGAAGAAGCTGACCGAGAACGCCAAGAGGCTTTTCGGCAGGCGCATCCACGGGCCTTTGGACAAGCGGGCCGGTGGGTTGCGGCGACGCAGGTAGACAAAAATCGCACCGACGAACATCACGGCCGTCATCAACAGCAGCGCATAACCGAGGATGCGGTTATGCAGGCCAAAACCGTGAACCAGAATCGCCAGTACGATGGACGCCACCGCGCCGCCTGCCGTGGCGACGTGGGTATTGGCGATGTATTTGTCCCGCGCGACAACATGGTGCAAGTCGACCATGTAGCGCTTGGGCATGGCGAACAGGCCGCCGATCAGGTCGACTTTCGACGCCCGGCCCCGGCGCCACATGGCCACCCGCCGCAACGCGCCCAGGACAGCCAGGCCCAGGGCAGCGAACAACAGGATTGGAAGAAGGGTGTTCAACATGGTGGAGCTCCCAAAGACCGCACGGTCTTGCAGGCCAAACTACCTGGATGCCTTGCCCGATGCCCTGTAGGAGCGAGGCTTGCCCGCGAAGGCGATGGATCAGCCGACATAAATGTTGAATGTCAGGACGCCTTCGCGGGCAAGTCGGAACGCCGCCCGCTCGTTCCTACAGGGTTATCCACAAGCTCTTAGAAATCCTTGCACAGCCGCAGTGCGTCATAGATGGCGGCGTGAATGTTCCGCTGCGCCACGCAGTCGCCAATGCGGAATAGCAAGTAGCCGTCGCCCGGTTGGCTCAACGAAGGTTGCGGCTTGATCGCAAACAAGGCTTCGACGTCGATCTGGCCCTTGTTGCGTGAACCTTCCTTCATCGCGTAGTAGATCTCTTCGTCCGGACGCACGCCGTTTTCCACGACCACCTGGTCCACCACCCGCTCCTCTTTGGCGCCGGTGTATTCGTTTTCCAGTACCGCGATCAGCTTGTCGCCTTCGCGGTAGACCTTCTCCAGCATCATGTCGCCGGTCATGATCACTTCTTTCGGGTACATGCTGCGGTAGTACGTCGGGAACGATGTGCCGCCAATCGCCACGCCGGGCTTGATGTCGTCGGTGACGATCTCGACCTGGCTGCCTTTGTCGGCCAGGAAGTCGGCCGCCGACATGCCGGTGAACTCGCAAATGGTGTCATAGACCAGCACGTTCTTGCCCGGCGCCACCTTGCCATCGAGGATGTCCCAGCTGCTGACCACCAGGCCTTCGGCCGCGCCCCAGTGCTCGTTCTGCTCCAGGTAGGAATGACCGCCAACGGCGAGCACCACCACGTCCGGACGCAGGTCGAGAATGGTCGGCGCATCGGCCGCCACGCCCAGGCGCAGGTCGACTTTCAACCTCGCCAGTTCCAGCTGGTACCAGCGCGTGATACCGGCGATCTGGTCCCGTTGCGGGGCTTTCGACGCGGTGGTGATCTGCCCGCCGATGAATTCCTTTTTCTCGAACAAGGTCACGTCGTGGCCTCGTTCGGCGGCCACACGAGCGGCTTCCATCCCCGCAGGGCCGGCACCGACCACCACGACTTTGCGTTTGACGCCCGTGGTTTTTTCGATGATGTGCGGCAGGCCCATGTACTCGCGGGATGTCGCGGCGTTCTGGATGCACAACACATCCAGGCCTTGGTATTGCCGGTCGATGCAGTAGTTGGCGCCGACGCATTGCTTGATCTGGTCGATCTGACCCATCTTGATCTTGGCGATCAGGTGCGGGTCGGCGATGTGGGCACGGGTCATGCCGACCATGTCGACGTAACCGCCCTCCAGGATACGGGTCGCCTGGTTCGGGTCCTTGATGTTCTGCGCGTGCAACACCGGCGCCTTGACCACTTCCTTGATACCGGCCGCCAGGTGCAGGAATGGCTCCGGTGGATAACTCATGTTCGGGATCACGTTGGCCAGGGTGTTGTGGGTGTCGCAACCCGACCCCACGACGCCGATGAAGTCCAGCATGCCGGTGTCGTCGTAATACTTGGCGATCTGTTTCATGTCCTCATGGGACAAGCCGTCCGGGTGGAATTCGTCACCGCACAGACGGATGCCGACGCAGAAATCCGGCCCGACTTCGGCGCGTACGGCCTTGAGCACTTCCAGGCCGAACCGCATGCGATTTTCGAAACTGCCGCCCCATTCATCGGTACGCTTGTTGACGCGCGGGCTCCAGAACTGGTCGATCATGTGCTGGTGCACAGCGGACAGTTCGACGCCATCCAGCCCCCCGGCCTTGGCCCGACGTGCGGCCTGCGCGTAGTTGCCGATCACCCGCCAGATTTCTTCCGGCTCGATGGTTTTGCAGGTGGCACGGTGCACCGGCTCGCGCACGCCCGACGGCGACATCAGCGTCGGCCAGTTAAAGCCGTCCCAACGCGAGCGACGGCCCATGTGGGTAATCTGGATCATGATCTTGGCGCCGTGCTTGTGCATGGCGTCGGCGAGATTCTGGAAGTGCGGAATGATGCGGTCGGTGGAGAGGTTCACCGAACTCCACCATTCCTGCGGGCTGTCGATCGCCACCACGGAGGAACCACCGCAAATCGCCAGGCCGATCCCGCCCTTGGCTTTCTCTTCGTAATACTTGATGTACCGGTCGGTGGTCATCCCGCCGTCGGTCGCGTAGACCTCGGCGTGCGCGGTGCTGAGCACGCGGTTGCGGATGGTCAGTTTGCCGATCTGGATCGGTTGGAACATTGCTTCGAAAGCCATGGCGGGATCCTCGACTTACAACGGCTTGACGGTGAACAAACCGTCGTCGTGGCCTTCTTCGGAGCCACCGTAGACTTGTTCGGCAACGGTGCGGATCTTGCTGCCGCGGGCTTGCAGAATCTGGTCCATGGCACCGGCAAACCAGCCAGTGAACATGTAGTCGACCTTGCGCCCGACCTTGCCGTACACATAGACAAATGCGGAGTGCTCGAGCTTGACGCTGGCGGTGCCTTTGTCGAGATCGATGTCCTGGATCTTGAACAGGCCCCAGCCACGTTGCGACAGGCGCTTCATGTAGTGTTCGAACACCGCGACGCCTTCCAGGCCGTGGCACTCGGCTTCTTTTTCACACCAGTGCCAGGCGGACTTGTAGCCGGCCTTGTAGAGGATCTCGGCGTAGGCGTCGGCGCCCAGCACTTCCTCGATGCCCATGTGGTTGTTGACGAAGAAATGGCGCGGTACGTACAGCATCGGCAGGGCGTCGGAAGTCCAGACACCGGTCTCGCTGTCGACTTCGATAGGTAATTGCGGGGCGATCTTGGCCATGGAAACTTAACTCCAGAAAAATTTTGGTGTTGCCTGCGGCGCGGATGGCCGCAGGAAAGGATTCAGAAGTGCGGCGGCTTATTCGCCCCAGACATCTTTCAAGACGTTGACCCAGTTCTCGCCCATGATCTTGCGCACCACGCGCTCGGAATGGCCGCGCTTGAGCAGGGTTTCGGTCAGGTTCGGGAACTCGCCGACGGTGCGGATGCCCAGCGGGTTGATGATCTTGCCGAAACTGGTCAGGCGACGGGCGTAGCCCTTGTCGTGGGTCAGGTATTCGAAGAAATCCTGGCCGTGGCCCTGGGTGAAGTCGGTGCCGATGCCGATGGCGTCTTCGCCAACGATGTTCATGGTGTATTCGATGGCTTCGGCGTAGTCGTCGATGGTCGAATCGATGCCCTTGGCCAGGAACGGTGCGAACATGGTCACGCCGACGAAACCGCCGTGGTCGGCAATGAACTTCAGCTCTTCATCGGACTTGTTGCGCGGGTGGATTTTCAGGCCCGACGGCAGGCAATGGGAGTAACAGACCGGCTTCTTCGATTCGAGGATGACTTCCTCGGAAGTCTTGGAGCCGACGTGGGACAGGTCGCACATCACGCCGACGCGGTTCATCTCGGCGACGATTTCGCGACCGAAGCCCGACAGGCCGCCGTCGCGTTCGTAGCAACCGGTACCAACCAGGTTCTGGGTGTTGTAGCACATCTGCACAATACCGACGCCCAGCTGCTTGAACACCTCGACGTAGCCGATCTGGTCTTCAAAGGCGTGGGCATTCTGGAAACCGAAGAGGATGCCGGTCTTGCCCTGCTCCTTGGCCTTGCGGATGTCGGCGGTAGTGCGCACCGGAATCACCAGGTCGCTGTTCTCGCGGATCAGTTTCTGGCTGGCGGCGATGTTGTTGACGGTGGCCTGGAAGCCCTCCCACACCGACACGGTGCAGTTGGCCGCGGTCAGACCGCCCTTGCGCATGTCTTCAAACAACTCGCGGTTCCACTTGGCAATAATCAGCCCGTCGATAACGATGCTGTCGGCGTGCAATTCGGCTGGGCTCATCAGGCTGTCCCCTATTAGCGATTCATGCGCCGAATCGTGTGCCGGCGCTTTGGGGCCAGCATATGCCTCGGTGCACTGGCAGCCGGGTGCAAAAACGACAGGGGAATTGCCGAAAGCGTCAATCCGCGACAAAGGGTCGTCAGCCGGCCGGATAAGCGACCTGTTCAAGCCCGTCCGCATACGCGAGAATCCATCGCATCACTGGATTTAGGGGCGGCGACGCGATGAAATCGATCTTTCTGGCTTTGGCATTGATAGCGACCGGCGCGCAGGCGGCTGAAGAGGCCGACGACAACCCCTGCGACGCCGTCGAAAACGAAATCCAGACCCTGGAATGCTCGGCCTACAGCAGAACCACGGCGGAAGACCTGCTGAGTGAAAACTACAAAAGCCTGACCGAGCGGCTGCAGATGCTCTATGGCAAGACCCCGGCGCAACTGACCGACGTCACCGCCAAGCTCAAGGCGGCCCAGCAACAGTGGCTGAAGACCCGGGACGCGGATTGCACCGTGGAGGCGTTCCCGGCGACCAGCGGCAGCAAGGCGTTCACCATTGCGCAGAACGATTGCGTGGCGCGGATGAGTGATGAGCGGTCGGAGTTTTTGGAGTCGATCGGGCAGGAGTAAGGACATAAGCATGGAGAATAATTTGATCCCACACGAAGTAGTCAGCCTTATCGTCGACGGTGCAACGCCTATTCGCGCCTGGCGCGAACACCTCAGCCTCACACAGGACGAAGTGGCCAAGCGCATGGGCATTTCCCAGCCGGCCTTCGCTCAGCAGGAAACCGTCGCCAAGCCTCGCAAGGCGACCCGTGAGAAAATTGCCGCGGCGTTTGGCATCACCGCCAACCAGTTAGAGCTGTAACCTGCACGCCAGCATGGCGACGTTGAACAAGTATCAGCATGAGGCTTACAAAACCGCGTGTTCGGTACTGATGAAGAAGTAACGGGTAGGAGCGAGGCTTGCCCGCGAAGACGGAGTACCAGTCGACAATGATTTCGAATGTGCCTTCCTCTTCCCGGGCAAGCCTCAAAAATAGTACCAACGCCAGCTACAGCTGTAAGAGATAGAGCAACACGATCAGGGCCTTCGGCGATTCCCACGTCGACACATTCTCCTGAGTTGTCGCTGGCTGTGGCCGCTTGCCCCTCTCATCGATTAATTGATTTGACCCGTGTCATGCCAAGCAGGGCAATTGATTGACCCGCTGTGGTACCACCAGCGAATCTGCTGCCTGCTCGTACTCGTAATCCAACGCGTCAATGTCCATGACTTCGCTGATCTTCAGCGTCCAGGGTTTGAGCACGTCATGGTAATTGTGGCCTTCAGGGCCGTTTTGCAGTGGCGCGTAATGCGGTGCCCATTGACCATTGTCTCGCACCATTCGCGCTTGCCAGTCGGCCCAGACTTTGTCGACGAAACAATGATGAAGAAAGAATACCGGGTCATCTGGAGAAGTCATCGGCAACATGTTGCCCCCCACCCAAAGATGAACCCGATTATGTAACTGGGAACTCGAAGTTGTGACCTGAGGGTCGCCTCGTTGGGTGATCCAGCCCTCCAGGCGGTTTCTGAAACCGCGCACGCAATGACTGGAGTCATACGGCGGCGTGTCGTAAAGACTTTCGCGCATTGCCATCTGCAGATCTTCAGGGGTTGGCAAAGAATTCACCACCAGACTGAACTGTCGCTTCAATCCAGGCCCTGGCAGGCCATCATCAGGATATGACGGGACGGGCCACTCCCCGTTCTTGTAGGCAAAAGGCCCGCTCGCCACCCGCCATTCGTCGCTCTCCACACCATTACCGCCCATGAAGTCGTCTTTCCACACCGGAGAGTTCAGCGGATCGGCGAAATCCTGTGTCCAGTCCCAATAGGGAATAGTGATCGAAGAGTCGATGGCCTGAAGGTCCGCTTCGAACTGAAGCAAGAAGGCTCGATGCCAGGGCAGGAAAGAGGGCCCCCGGTGGGCACCGTTTCTGTAATTGGGGTCATTCGGCTCATGGGGCAGAACGGTGGGCACCATGACGTGATGATGCTGATGCACGTACCGATCGTATTGCCCTGAGGCCTTGAGCTGAAGACAAGCAGCGACAAATTTCTGTTTTTCAACACTGCTCAACGAGCGAATATTTTTCCGAAGTTTCATCTGACTTGATCCTTAAGTGATTACCAGAACTGATGTCCCTGAAATGGGCCTGGCACCGGTAAAAATAAGGGCGGCATCGATAGGCAGGTACTCTCAGAAATGATAGGTCAACGCGATTTGCCGACCAACGGTCGAGCTTTCGCTGGTGACACGCCTCGGGATGACTTCATGCCTCGACTACGTCAACATCAAGGCTTTGCGGTTCGCTCATAGGGACATCAGTTCATGAATATCTGCGGTATCGAAATCAAAGGCAGCGAAGCGATCATCGCCGTGGCCTCCCTCGACGATCAGGTGCTCAGCCATGTTGCGCTGAGCACCAAAAAGATCGCCCTCGACGATGACGACGAGGCCGCGAACGTCAAAGTGTTTGCCGCTCAGGTCGCGTCGTTTGTGCGTGAGCATTCCATCGATCGGATCGCAATCAAGAAACGCAGCAAGAAAGGCGAATTTGCCGGTGGACCGACCACGTTCAAGATCGAAGGGATTTTCCAGTTGCTGGAGAATTGCGAAGTAACGCTGCTGTCGCCGCAGACGATCAATGCGCAGAACAAGAAGTTTGATTTTGCGCTGCCGGCGACGCTGAACAAGTATCAGCATGAGGCGTTTAAAGCGGCGTGTTCGGCATTGATGAAAAAGTAAGACTGCAACAGATCAAAACTGTGGGAGCGAGCTTGCTCGCGATAGCGGTGTATCAGACACCTGGATGCTGACTGTTACGACGCCATCGCGAGCAAGCTCGCTCCCACAGGGTTTTCTGGTGCTGTCGAAATCTTCGCTTAGACAAGTTCCCGGCCATCGCCCAACCGACGCCGGTCCTCCCGCGGACACCGCGCAAACCGCGCCCGATAACTGCGGGCGAAATACGACGGCGATTCAAACCCGCAGGCAATACTCACCTCCAGCACGCTCATATCCGTCTGACGCAACAATTGCCGGGCCTTTTCCAGCCGCAAGCGCAGATAGAAATTGCTCGGCGTGTCGTTCAGGTGCAGCCGAAACAAACGCTCCAGCTGCCGGCGCGTCACCTTGATCGATTCCGCCAGTTCCAGCGTGCTCAACGGCGGTTCGCTGTGCTGTTCCATTTCGCCAATAACGTGAACGAGTTTCTTATTGCTGATGCCATAGCGCGTGGCGACTTCCATGCGCTGGTGGTCTTTGCGTGGGCGGATGCGCCCGAGTACGAATTGTTCGCTGACCTGGATCGCCAGTGCCGGGCCGTGGGCCTGGGCGATGAGATCGAGCATCAGGTCGATGGAGGCAGTGCCGCCCGCTGACGTGATGCGCCGGCGATCGATCTCGAACAGCTCTTGGGTAACGCTGAGCTGTGGGTAAGACTCCTTGAACGCGTCGATGGCTTCCCAGTGCAAGGTCAGGCGATGGCCGTCGAGGAGGCCGGCTTCGGCGAGGACGAAGCTGCCGGTGTCGATGGCGCCGAGGGTCACGCCTTCGTTGTCCAGGCGGCGCAACCAGTGCTCCAGGGCCGGGGTGGCGAACTTCAGCGGTTCGAAACCGGCGACCACCAATAGGGTTGCACCTTTTTTCAGCGGTTCCAGCGCAGCGTCGGCGTTGACCGACATGCCATTGCTGGCCAATACCGCGCCCCCGTCGGCACTCAGCACATGCCAGCGGTATAGCTCGCCGCGAAAGCGATTGGCGACCCGCAGCGGCTCGATGGCCGAGATGAACCCGATGGCCGAGAAACCCGGCATCAACAAGAAGTAGAAATCCTGGGACATGTAGCGCACTCGACTGGCAGGTAACGAGAGGCGGGAAGCGTGTGGACGTTGATACGCCAGTTGCACGCGGCATTCAAGAGCACAGGTCGCTGCAGTGCAAGAGCTGGTCGCCGCAGTGCGCTTTCACGGGGTCTATGCTGCGTAACTTGTCATCACCGGCGCATGAAGACGCCGGAACCCACAATAACGTCTGCCGAGGAACCCGACATGAAACGACTGATCAGCAGCTGTGTTCTTGCACTCAGCGGTACCGCCTTATTGAGCGCCAGTGTCATGGCGGCCGAACCTGCGTCATGCCAGAACGTACGCATGGGCGTCGTGAACTGGACCGACGTAATCGCTACAAGTGCCATGACCCAAGTCCTGCTCGACGGCCTCGGCTACAACACCAAACAAACCAGCGCATCCCAGCAAATCATCTTCGCCGGGATCCGCGACCAGCGCCTGGACCTGTTCCTGGGCTACTGGAACCCGTTGATGACCCAGACCATCACGCCGTTCGTCCAGGCCAATCAAGTCAAGGTGCTGGAAGCGCCCAGCCTGAAAGATGCCCGCGCCACCCTCGCCGTTCCGACTTACCTCGCCGACAAGGGCCTGAAAACCTTTGCCGACATCGCCAAATTCCAGAAAGAACTGGGCGGCAAGATCTACGGCATCGAGCCTGGCTCGGGCGCCAACACCCAGATCAAGGCGATGATCGCCAAGAATCAGTTTGGCCTGGGCAAGTTCCAGCTGGTCGAGTCCAGTGAGGCCGGCATGCTCGCCGCAGTGGATCGCGCCGTGCGGCGCAAGGAAGCGGTGGTGTTCTTCGGCTGGGCGCCGCACCCGATGAACGTCAACGTGCAGATGACTTACCTCACGGGCAGCGAAGACGCCCTGGGCCCGAACGAAGGCATGGCCACGGTCTGGACCGTCACCTCGCCCAACTACGCGCAGCAGTGCCCGAACATCGGCCGCTTGCTGAGCAACCTGACCTACACCGCCGAAGACGAGAGCCGGATGATGCAGCCGCTGCTGGAGCACAAGGACGCTTTCGAATCGGCCAAACAATGGTTGAAGGATCACCCGCAAGACAAGCAACGCTGGCTTGAAGGTGTGACCACCTTCGATGGCAAACCGGCGGCTGACAACCTGAAATTGACCACCCAATAAACCCGATTGAACCACCGATTCGCAGCCCGACCGGGCTGCGAACGGAATCATCACGCCTGCAAGGAACCCGTCTCATGAACCACGACGTCATCATCACCTGCGCACTCACCGGTGCTGGCGACACGACCGCCAGAAGCCCGCACGTGCCGGTCACCCCGAAACAAATCGCCGCAGCCGCCGTGGAAGCCGCCAAGGCCGGTGCCACCGTGGTTCACTGCCACGTTCGCGACCCGCAAACAGGCAAATTCAGCCGTGACGTCGCGCTGTACCGCGAAGTGATGGAGCGCATCCGCGAGGCGGACGTCGACATCATCGTCAACCTCACCGCCGGCATGGGCGGCGACCTGGAAATCGGCGCGGGCGAGAACCCGATGGAGTTCGGCCCCAATACCGACCTGGTCGGCCCGCTGACCCGCCTGGCCCACGTCGAAGAACTGCTGCCGGAAATCTGCACCCTCGATTGCGGCACCCTGAACTTCGGCGACGGCGACACCATCTACGTGTCCACCCCGGCGCAACTGCGTGCCGGCGCCAAACGCATTCAAGAGCTGGGCGTGAAAGCCGAGCTGGAAATCTTCGACACCGGTCACCTGTGGTTTGCCAAGCAGATGATCAAGGAAGGCCTGCTGGACAACCCGCTGTTCCAGCTCTGCCTGGGCATCCCGTGGGGCGCGCCGGCGGACACCACCACCATGAAAGCCATGGTCGACAACCTGCCAGCCGACGCGGTCTGGGCCGGCTTCGGCATCGGTCGCATGCAGATGCCGATGGCGGCACAAGCGGTGCTGCTGGGCGGCAACGTACGGGTCGGCCTGGAAGACAACCTGTGGCTGGACAAGGGCGTGCTGGCGACCAACGGCCAACTGGTCGAACGCGCCTCGGAAATCCTCAGCCGCCTCGGCGCCCGGGTGCTGACCCCGGCGGAAGGCCGGACAAAAATGGGCCTGACCAAGCGCGGCTAAACCCACACAAAAAACCTCTGTAGGAGCGAGGCTTGCCCGCGAAGAGACCGGTACATCCGCCACATACTCCGCGGCTGGACCACCGTCTTCGCGAGCAAGCTTCGCCCCTACAGGGCATCACCAAATTCTTCAGGACGTTGCCATGACCTTTATTACCGAAATCAAAACCTTCGCCGCCCTGGGCAGCGGCGTGATCGGCAGCGGCTGGGTCTCCCGCGCCCTCGCCCACGGCCTCGACGTCGTGGCCTGGGACCCGGCGCCCGGCGCCGAAGCCGCCCTGCGCAAACGCGTCGCCAATGCCTGGGGCGCACTGGAAAAACAAGGCCTGGCACCCGGCGCATCACAGGATCGGTTGCGCTTTGTCGCCACCATTGAAGAATGCGTTCGCGACGCGGATTTCATTCAGGAAAGCGCCCCTGAGCGTCTGGACTTGAAACTGGAACTGCACAGCAAAATCAGTGCGGCGGCCAAACCGGATGCCCTGATCGGCTCCAGTACCTCCGGGCTGTTGCCGAGTGAGTTTTACGAAAGTTCGACCCACCCGGAACGCTGCGTCGTCGGGCACCCGTTCAACCCGGTTTATCTGCTGCCGTTGGTCGAAGTGGTAGGTGGCAAAAACACTGCACCAGAAGCCGTGCAGGCAGCGATGAAAGTTTACGAATCCTTAGGCATGCGTCCGCTGCATGTACGCAAGGAAGTGCCAGGCTTTATCGCCGACCGCCTGCTCGAAGCGCTGTGGCGTGAAGCGCTGCACCTGGTCAACGATGGCGTGGCGACCACCGGTGAAATCGACGATGCCATTCGTTTTGGCGCCGGTCTGCGCTGGTCGTTCATGGGGACTTTCCTGACTTACACCCTGGCTGGAGGCGACGCGGGCATGCGCCACTTCATGGCGCAGTTCGGGCCGGCATTGCAGTTGCCGTGGACCTATTTGCCGGCGCCGGAACTGACAGACAAGTTGATCGATGATGTGGTGGATGGCACCAGTGATCAGCTGGGAACGCACAGCATTTCGGCGCTGGAGCGCTATCGTGATGATTGCCTGCTGGCGGTGCTTGAGGCGGTGAAAACCACCAAAGAGAAGCATGGGATGGCGTTCGCCGAATAATTATCCAGCAGGACCGACCCTTTCGCGGGCAAGCCTCGCTCCTACAAGGATTACGCGCATTCCTGTAGGAGCGAGGCTTGCCCGCGAAAGCGGCAGTCCAGTCAACACACATCTTGGATCACTCACCATGCCCACCCTCACCACCTACCAAACCACAATCATCCCCGACTGGGTCGACTACAACGGCCACCTGCGCGATGCCTTCTACCTGCTGATCTTCAGCTACGCCACCGACGCACTGATGGATCGGCTGGGTATGGACAGCAACAACCGCGAAGCCAGCGGCAACTCGCTGTTCACCCTCGAACTCCACCTCAACTACCTGCACGAAGTGAAGCTCGATGCCGAAGTCGAAGTGCACACGCAAATCATCGGCCACGACAGCAAACGCCTGCACCTCTACCACAGCCTGCACCTGGTGGGCGATGACAAGGAACTGGCAGGCAATGAACAAATGCTGCTGCACGTCGACCTCGCCGGGCCGCGATCCGCGCCCTTCAGTGAAGAGACCTTGAGCAAGCTGCAAGCCATGGTCGCCGAGCAAGCCGACTTGCCCGCCCCCGCCTGCATTGGCCGCGTGATCGCGCTGCCACCGGCAAAATAGCCACCACCGAACAATCACCCTCGAACAAGGAGATCGCCATTGAACACCGCCGCCGCTTTTGCCGACTTCCGCACTTACCCGTTGATCAGCGCGCTGGCTGGCGTGCAAGCCCTGACGGATCGCGTTCTGGTGAAATGGGCCGACGACCGTGTCAGTCCGTTTCACCACCAATGGCTGCGGGACAACTGCCCGTGCCCACTGTGCGTCTACACGGTGACTCGCGAGCAGGTGCTGGAAATCGTCGATGTCGAAGAAAATCTCCTGCCCGCAGAGACAAGCGTCGACGCTGAAGGCTGCCTCTGCGTCGCATGGCAGGACGGCCACCGCAGCCGCTTCGATCCGGGCTGGCTACGGGCCCACGCTTATGACGATGAGTCCCGTGCCGAACGCCGCGCCGGCAAACCGCAAGCCAGGCTCTGGAACAGTGATCTACAGTTGCCGGTGTTCGACTACGCGGCGCTGATGAACGATAACGACGCGCTGTTGCAGTGGCTGTTGGCGGTGCGCGACATCGGCCTGACCCAGGTCCGTGGCGTGCCCACCGAGCCCGGCTCGCTGAAGCTGATCGCCCAGCGGATTTCCTTCATCCGCGAGAGTAATTTCGGTGTGCTGTTCAACGTGCAATCCAAGGCCGATGCCGACAGCAACGCCTACACCGCCTTCAACCTGCCGCTGCACAGCGACCTGCCGACCCGGGAGTTGCAACCAGGGCTGCAATTCCTGCATTGCCTGGTCAATGACGCCGAGGGTGGCGAGAGTATTTTCGTCGACGGTTTTGCCATCGCCGACGCCTTGCGCCAGGAAGATCCCGAAGCGTTCCAGGCCTTGTGTGAAATCCCCGTGGAGTTTCGCAATAAGGACCGTCATAGCGACTACCGCCGCCTCGCGCCGATCATCGCTTTGGACGCTTCGGGACAGGTGTCGGAAATCCGCATGGCGAACTTCCTGCGCGGCCCGTTCGATGCGGCGGTGGAGCAGATGCCGAAGCTGTATCGCGCTTATCGCCGGTTCATCGCCATGACTCGGGAGCCTCGATTCAGGCTGATGCAAAGGCTCAATCCCGGGGAACTGTGGTGTTTCGACAACCGTCGTACGCTCCATGCGCGCAATGCTTTCGACCCGGCCACTGGCGCGCGGCATTTCCAGGGTTGCTATGTTGACCGGGATGAATTGCTGTCGCGGATCCTCGTTTTACAACGTTAGACCGCGTCATATTCTTCGCGGGCAAGTCGGATCGCCGCACCGCTCGCTCCTACAGGAGATCGCATACCTCTGTAGGAGCGAGCGGTGCGGCGATCCGACTTGCCCGCGAAAGCGTCAGCCCAGACACCACCTGCATTCCTGATTCACAGGCAAAAAAAACCCCGATCAAGCCGTGACAGGATCGGGGCAGAGGTGGGTAACTGTTGAGGAGCCGTTGCGCGAGGGTGACCAAACCTTCGTGAAGCCAGCTGAATCCAGTGTGCCCCGTCCTCTCTTTAGAAAGTTAGCCGAAAACGACATGTTCATAGCCATTGCGGTCATTGCGACAAATTGCCCTTGCCGCCACCCCGGGGCCCTACCAGAATCGAGCCAAGACAACGTTCCCTGAAGAAGGATTGCGTCATGATGCACGCTGATTTGATTGACCAGGAAGACCTGTTGGGCCAGCTGAAGGCGTTGGGATTTGCAGTGCCCCCTGGCGCTACCGCCGAGCAGGCCTGCGAATGCGCGGTACGGGGTTTGAACAACGAACGGGCAACGGAACTGCGGACCATGGTCAAGCAGATGTACACCAGCAGCGCGACCATCCTGCCGGCCGTGCGCCAGGCTATCGACAAGCAATTGCTGCCGGCACTGGCGGAGTATCAGCAAAGCCGTAGTGTCTGACAGGACGCCTTCGCGGGCAAGCCCGCTCCCACAGTTGACCGCATTCCCCTAAGCGAACTCGGTCAATGTGGGAGCGGGCTTGCTCCGGGCGGCGTTCCGACGAATGCAGGCGCCCCGGTCTAGAGCCTTACGCTAGCAAAAGTCGACTCATTACGCGCCTGACTCAACGCCGACAACGGCCCGGACAACGGCGACAGCACCAGTGCCTGTGGCAGCGGCATCATCGCCACTTGCTGCGTGGTGTTGGAACCGACGCGTTCGTCGCGTGGCGGAATGCCGAAGTATTCGCGGTAGCACTTGGAGAAGTGCGGCGTAGACACAAACCCACACACCGATGCCACTTCGATGATCGACATCGGCGTTTGCTTGAGCAACTGCCGGGCGCGGATCAAGCGCAGTTTCAGGTAGTAGCGCGACGGCGAGCAGTGCAGGTATTTCTGGAACAACCGCTCCAGCTGACGACGGGACACGGCGACGTACACCGCCAGTTCGTCGAGATCGATCGGCTCCTCCAGGTTGGCTTCCATCAGCGCGACGATTTCCTGCAGCTTCGGCTGGTTGGTGCCGAGCATGTGCTTGAGCGGTACACGCTGGTGATCCTGCTCGTTGCGGATGCGCTCGTAGACGAACATTTCCGAGATCGCGGCCGACAGTTCACGTCCGTGATCGCGGCTGATCAGGTGCAGCATCATGTCCAGCGGTGCGGTGCCGCCGGAACTGGTGAAACGGTTACGGTCCAGGGTGAACAGGCGCGTACTCATGGCGACACGCGGGAAGGCTTCCTGCATCGAGGCCAGGCATTCCCAGTGCACGCTGCAGTCGAAGCCGTCCAGCAGGCCGGCGCAAGCCAGGGCCCAGCTGCCGGTGCACACCGCGCCGAGACGGCGGGACTGACGGGCCTGGCTTTGCAGCCACGACACGTGTTCACGGGTAACGGTACGCTGGATGCCGATACCGCCGCAGACAATGATGGTGTCCAGGGCGGGCGCTTTGTGCATGGAGCAGTCGGGGGTGATCTGCAGACCGTCACTGGCCCAGACCTGACCGCCATCGACGGTGATCGTGGTCCAGCGATACAGTTCGCGACCGGACAATTGGTTGGCCATGCGCAGGGGTTCTACTGCGGACGCCAGAGAAATAAGCGTGAAATTGTCCAGCAGCAGAAAGCCGATGGATTGAGGCGCACGGTTCTGGGGTTGGGCCCCGGAGTTGAACGTCGTCATCGCGGTATCTCCTCACACAAAGCGGGTGATGGCCTCAGGCGGAGGCTCTTGTTATGGCCATCGTTCTCTCGTGGGAGACGGGCTTTGTAATGACAGAGCAATTGCCATGCCTAAAATTGAATGCGTGTTCAATAACTCCTGAAAACGACGTCGCGATGTGTCTGGATATGACGCAAATAGAGTGTGGAATTTATGTGCCATCAATGGCAGCAAGCGCGCTGTCCCGTTACCTGTGAGCAAATCGGTAGCACTTGTGGGAACAGGTCTGCGACGGGGCTGGGAAGAGTGTCACCACAAGCACGGGTGACGGGCGGTAATGGCCAATCTGGATCCGTGATCCAGATGAAGGCGCTTATCTGTAAGCGACGCGCCAAAACGTGGCGCGTTTTGAATCGGGTGTTCATTTAGTGCGCAGTTTTGACTGGTCTGGCGCCTTCGCGGGCAAGCCTCGCTCCTACAGGTTTTGTATTGCCCTTGTAGGAGCGAGGCTTGCCCGCGAACGAGGCGACGCGGTCTTACTGAATCAACACTCCACCGCGCTAACCGCCAACCCGCCCCGCGATGTCTCTTTATATTTGTCATGCATATCAGCCCCGGTATCACGCATGGTGCGGATCACCCGATCCAGCGAGATAAAGTGCTGACCGTCGCCCCGCAGCGCCATCTGTGCCGCGTTGATCGCCTTCACCGCCGCAATCGCATTACGCTCGATGCACGGCACCTGCACCAGCCCACCCACCGGATCACAGGTCAGGCCGAGGTTGTGTTCCAGGCCGATCTCCGCCGCGTTGCACAGTTGCTCCGGCGTAGCCCCGAGAATCTCTGCCAACCCCGCAGCCGCCATGGCGCAAGCCGAACCGACCTCGCCCTGGCAACCGACTTCCGCACCGGAAATCGAAGCGTTCTTTTTGCACAGGATCCCCACCGCCGCCGCACTGAGGAAATAGTCGACCACGTTGGCGTCGGTCACCGCTTCGCTGAACTTCATAAAGTAGTGCAGGACCGCCGGAATGATGCCCGCCGCGCCGTTGGTCGGTGCCGTGACCATACGCCCGCCAGCGGCGTTTTCTTCATTGACCGCCAGGGCGAACAGGTTGACCCACTCCATGGCGCTCAGGGTCGAGCCAATCACGTTGGGCTTGTTCAACTCCTGCAGGCTACGGTGCAGCTTGGCCGCGCGTCGGCGCACATTCAGGCCGCCAGGCAGGATGCCTTCGTGCTTGAGGCCCTGTTCGACGCAATCCTGCATCGCGCGCCAGAGCTTCATCAGGCCGGTACGGATTTCTTCTTCGCTGCGCCAGACCTTCTCGTTGGCCATCATCAGTTCGGCAACGCGCAGGTCGTGCTGCTTGCACAGACTGAGCAGCTCGGCGGCGCTGGAGAAGTCGTACGGCAACACCGTGCGATCCAGGTCCACCACTCCGCTGCTGGCTTGTGCTTCATCGACGACAAACCCGCCGCCGATGGAATAGTAGGTATCGCGATGCAGCTCACCGTCATCACCCTCGGCAACCAGGGTCATGGCGTTGGGATGGAATGGCAGGTTTTCGTCGATCAGGCGCATATCCCGGGCCCAGATGAACGGCACCGGCAAACGCCCATCGAGCAACAGCGTGTCGGTTTCACGCAAGGTGGCGATATGGAGGCCGATCTGCGACGGATCGATCGCGTCCGGCCACTCGCCCATCAGCCCCATGATCACTGCGTTGTCGCTGCCGTGTCCGATGCCGGTGGCTGACAGCGACCCGTACAGCTGAACCTCGATACGCCGCACTTGCTCCACAAGCCCCTGCTCACGCATACCTTGCACGAACAACGCCGCGGCCCGCATGGGCCCAACGGTGTGCGAACTGGAAGGGCCAATACCGATTTTGAACAGGTCGAAAACGCTGATAGCCATTGCTGCCGAACTCCTGGATGTGCCAACTCCAGACGCAAAAGCGCCTGGCGACGGAGCTGCTACGCTCAAGCTGCAATCCGCCGGTATGGCTGCATCATCAGGCTTTTACCCTGTCATTCGACGTCTGACACCGACGTACTCTTGTCCACAAACGCCGCGTGCGTTTTACGCTGTGTTTTCGGCGTTTTTTTGCAGTTCAGAGCAACGAACAGGGCTGAAAAAAGCTGTAAGCGACGTCACCGACACTGGATGCGACCCTCCCTGTACTGGTTACGACGCACCCTGTAGGCGTCAGATTTTCACTGGTACATGATCGTATCGACTCGATTGCAAGGCGCCGTGGTAGAGATGTCTCCAAAACGCCATCCAACCGCAACCTATAAGTGCGGTGGTCCAGTCGGAACACTGCCAAAAAAAACACCAAGGAGTCCATTCATGAAAGGTTCCCCGCCGTTGTTGTTGGCCGCCATGCTGAGTCTGCCGTTTCTGGCGCAAGCCGCCGAACCGGCTCAGTGCAAAACCGTAAACTTCTCCGATGTCGGCTGGACTGACATCACCGTGACTACCGCCACCACCAGCGTCGTGCTCGATGCCCTGGGCTACAAGACCAAGACCACGATGATTTCCGTGCCGGTGACCTACAAATCCCTGGCCGATGGCAAGAACATGGACGTATTCCTGGGTAACTGGATGCCGACCATGGAAAACGACATCAAGGCCTACCGCGATGCCGGCACCGTGGACACCCTGCGCGCCAACCTGGAAAACGCAAAATACACCCTCGCCGTCCCCGAAGAGTTGTATAACAAGGGTCTGAAGGATTTTGCCGACATCGCCAAGTTCAAGAAAGAACTCGACGGCAAGATCTACGGCATCGAACCGGGCAACGACGGCAACCGCCTGATTCAGAGCATGATCGACAAGAACGCCTTCGGCTTGAAAGACGCCGGCTTCAAGGTGGTCGAATCCAGCGAGGCAGGCATGCTCTCGCAAGTCGATCGCGCCCAGCGCCGCAACACCGCCGTGGTGTTCCTGGGCTGGGAACCGCACCCGATGAACACGCGTTTCAAGATGAAGTACCTGACCGGCGGCGACGACTTCTTCGGCCCGAACTTCGGTCAGGCGACCATCTTCACCAACACCCGCAAGGGCTACGCGCAGGAATGCAGCAACGTGGGTCAGTTGCTGAAAAACCTGGTGTTTACCCTCGACATGGAAAGCACGCTGATGGGCAACGTCCTGGACGACAAAATGAAGCCTGACGCGGCCGCCAAGGCCTGGCTGAAAAAGAATCCACAGGTCCTCGATACCTGGCTCGCTGGCGTGACCACCATTGACGGTAAACCAGGCCTGGAGGCCGTTAAAGCCAAGCTCGCTCAGTAATCGCTTACGCCGGGGGAGGCAACTTCCCCGGGCTGTTTATTTCCTTGCATGCGGACGTTCACTACCATGCTGATTGATCAGAAAATACCTTTAGGCCAGTACATCGCAGGCTTCGTTGAATGGTTGACGCAAAACGGCGCCAGCACTTTCGACGCCATCGCCGTGTCACTGGAAACGATGATCCACGGCGTGACTTTCGCGCTGACCTGGTTCAACCCGCTGGCATTGATCGGCCTCATCGCGCTACTGGCACACTTCATTCAACGAAAGTGGGGCCTGACCGTTTTTGTCATCGCCTCCTTCCTGCTGATCCTCAACCTGGGGTACTGGCAGGAAACCATGGAAACCCTCGCCCAGGTGTTGTTCGCCACCCTGGTCTGCGTGCTGATCGGCGTGCCATTGGGCATCGTCGCCGCGCATAAACCGATGTTCTACACAGTGATGCGGCCGGTACTCGATCTGATGCAGACCGTGCCGACCTTCGTCTACCTCATTCCTACCCTGACCCTCTTCGGTCTGGGTGTGGTCCCGGGCCTGATTTCCACGGTGGTGTTCGCGATTGCCGCGCCCATCCGCCTGACTTACCTGGGTATTCGCGATGTCCCGGAAGAATTGATGGACGCTGGCAAGGCCTTTGGCTGCTCGCGACGTCAACTGCTCTCACGGATTGAATTGCCCCACGCCATGCCAAGCATCGCGGCCGGTATCACCCAGTGCATCATGCTGTCGTTGTCGATGGTGGTGATCGCGGCACTGGTGGGCGCCGACGGCCTGGGCAAACCCGTGGTCAACGCACTGAACACTGCTGATATCGCCCTGGGCTTCGAAGCAGGCCTGGCGATCGTACTGCTGGCGATCATGCTCGACCGTATCTGCAAACAACCCGAAGCCAAAGTAGGGGGTGACGCATGAGCATTATTCGCTTCGATAACGTCGACGTAATTTTCTCCAAGGATCCACGCGAGGCACTCAAGCTGCTGGATCAAGGCATGACCCGTAACGAGATCCTGAAAAAGACCGGGCAGATCGTAGGGGTCGAAAAGGCCAGCCTGGACGTCGAAAAAGGTGAAATCTGCGTACTGATGGGCCTGTCCGGCTCGGGCAAGTCCAGTCTGTTGCGCTGCATCAACGGCCTCAACACCGTCAGCCGCGGCAAATTGTTCGTCGAGCACGAAGGCAAGCAGATCGACATCGCCTCTTGCACTCCGGCAGAACTGAAAATGATGCGCACCAAGCGCATTGCGATGGTGTTCCAGAAGTTCGCCCTGATGCCTTGGCTGACCGTTCGCGAGAACATCAGTTTCGGTCTGGAAATGCAGGGTCGCCCTGAGAAAGAACGCCGCAAACTGGTGGATGAAAAGCTTGAGCTGGTGGGGCTGACCCAATGGCGCAACAAGAAACCCAACGAGCTGTCCGGTGGTATGCAACAACGCGTGGGCCTGGCCCGTGCACTGGCGATGGACGCCGACATCCTGCTGATGGACGAACCGTTCTCGGCCCTCGACCCGCTGATCCGCCAGGGCCTGCAGGACGAACTGCTGGAACTGCAACGCAAACTGAGCAAGACCATCGTTTTCGTGAGCCACGACCTCGATGAAGCCCTGAAGCTCGGCAGCCGTATTGCAATCATGAAAGACGGTCGGATCATTCAGTACAGCAAACCTGAAGAGATCGTGTTGAACCCGGCGGACGATTACGTGCGGACATTCGTCGCCCACACCAATCCGCTGAACGTGCTGTGCGGTCGCAGCCTGATGCGCACCCTGGACAATTGCAAGCGTATCAACGGTTCGGTATGCCTGGATCCGGGTGGCGATTCGTGGCTGGACCTGGCCGAAGGCAACACCATCAAGGGCGCTCGCCAGAACGGCGCGAGCCTGGACCTGCAGAACTGGATCCCAGGGCAAGCGGTTGAAGGGTTGGGGCGTCGGCCGACATTGGTCGACTCCAACATCGGCATGCGCGATGCCTTGCAGATCCGTTATCAGACCGGCAACAAGCTGGTGCTGCACGATAACAACAAGGTGGTCGGGATTCTCGGGGACAGCGAGTTGTATCACGCGCTGCTCGGCAAGAACCTGGGGTAA

Protein sequences of DBSCAN-SWA_4

>NZ_CP014870|6282764:6331603|6303108_6304209_-|WP_064680169.1|DBSCAN-SWA
MSNSFLNPVTTQTWANGRHIVRCVKVIQETWDVRTFCFMADQPILFFFKPGQFVTLELEIEGVPIMRSYTISSSPSVPYSFSVTIKRVPGGKVSNWLHDTLHEGQELAVHGPVGLFNAMDFTAPKVLYLSGGVGITPVMSMARWFYDTNGNVDMVFIHSARSPKDIIYHRELEHMASRIDNFSLHLICEKHGLGEPWAGYRGYLNQKMLELMAPDFMEREVFCCGPTPYMNAVKRMLEMIGFDMSRYHEESFGATPPEARADAVEQAEIAADAPDIDVADLHQVEFTASGKSIRVAPGETVHAAAAKLGLLIPKACGMGICGTCKVLKLGGEVDMDHNGGITEEDEAEGFILSCCSVPKGDVRIEF
>NZ_CP014870|6282764:6331603|6324746_6325010_+|WP_064680186.1|DBSCAN-SWA
MMHADLIDQEDLLGQLKALGFAVPPGATAEQACECAVRGLNNERATELRTMVKQMYTSSATILPAVRQAIDKQLLPALAEYQQSRSV
>NZ_CP014870|6282764:6331603|6282764_6283271_-|WP_064680154.1|protease|DBSCAN-SWA
MKSLLALLSLVALPILAAEPTLYGRYEYIALPEIGGEVLKAKMDTGALTASLSAKDIETFTRDGDEWVRFRLGTKDASNKVYEHKVARISKIKTRSEEGDDDDEDVAPTKRPVVDLELCLGNVKRTVEVNLTDRSSFNYPLLIGAKALREFGAAVNPARRFTADKPDC
>NZ_CP014870|6282764:6331603|6313837_6314368_-|WP_008033249.1|DBSCAN-SWA
MAKIAPQLPIEVDSETGVWTSDALPMLYVPRHFFVNNHMGIEEVLGADAYAEILYKAGYKSAWHWCEKEAECHGLEGVAVFEHYMKRLSQRGWGLFKIQDIDLDKGTASVKLEHSAFVYVYGKVGRKVDYMFTGWFAGAMDQILQARGSKIRTVAEQVYGGSEEGHDDGLFTVKPL
>NZ_CP014870|6282764:6331603|6307614_6308385_-|WP_064680172.1|DBSCAN-SWA
MSTKIISLVSIGAHPTSGRPRRAEQDARAVELGLQLAGDNLQVLHAGDVAEPALRAYLGMGLEQLHVLEQPVGADALPALTAYLRDAGAQVVLTGSQAETGEGSGMLPFLLAESLGWPLVVGLAQVESIDGSSALVLQALPRGQRRRLKVRLPFLATVDNAAPKARQSAYGPARRGVLQADEVEVVDDELLAVATLQPAKPRPKRLKVIKAKSGADRMKAATAKASGGGGQVLKGVTAQAGAEAILKLLIEEGVVR
>NZ_CP014870|6282764:6331603|6292083_6292941_-|WP_064680161.1|DBSCAN-SWA
MSRAPDTWILTADCPSVLGTVDAVTRFLFEQGCYVTEHHSFDDRLSGRFFIRVEFRQPDGFDEQSFRAGLEERGQAFGMIFELTAPNYRPKVVIMVSKADHCLNDLLYRQRIGQLSMDVAAVVSNHPDLKPLADWHQIPYYHFPLDPNDKPSQERQVWQVIEESGAELVILARYMQVLSPELCRKLDGKAINIHHSLLPGFKGAKPYHQAYNKGVKLVGATAHYINNDLDEGPIIAQGVEAVDHSHYPEDLIAKGRDIEGLTLARAVGYHIERRVFLNANRTVVL
>NZ_CP014870|6282764:6331603|6293863_6296881_-|WP_064680163.1|DBSCAN-SWA
MSQINRLSNGGRIDRNKVLSFTFNGQSYKGFEGDSLAAALIANGVDIIGRSFKYSRPRGIFAAGAEEPNAVLQIGATEATQIPNVRATQQALYQGLVATSTNGWPSVNNDMMGILGKVGGKLMPPGFYYKTFMYPQSFWMTYEKYIRKAAGLGRSPTENDPDTYDYMNQHCDVLIVGAGPAGLAAALAAARSGARVILADEQEEFGGSLLDSRESLDGKPAIEWVASVIDELKNTPDVLLLPRATVNGYHDHNFLTIHERLTDHLGDRAPIGQVRQRIHRVRAKRVVLATGTHERPLVYGNNDVPGNMLAGAVSTYVRRYGVAPGKKLVLSTNNDHAYRVALDWLDASLQVVAIADARSNPRGALVEEARAKGIRILTGSAVIEARGSKRVTAARVAAIDVKAHAVTSPGEWLECDLVASSGGYSPVVHLASHLGGKPIWRDDILGFVPGEAPQKRVCVGGINGVYGLGDSLADGFEGGARAASEAGFSGVEGTLPKALSRVEEPTLALFQVPHEKNSARAPKQFVDFQNDVTAGGIELATREGFESVEHVKRYTALGFGTDQGKLGNVNGLAIAARSLNVTIPQMGTTMFRPNYTPVTFGAVAGRHCGHIFEPVRFTALHHWHVKNGAEFEDVGQWKRPWYFPKNGEDLHAAVKRECKAVRDSVGLLDASTLGKIDIQGPDSREFLNRIYTNAWTKLDVGKARYGLMCKEDGMVFDDGVTACLADNHFVMTTTTGGAARVLQWLEIYHQTEWPDLKVYFTSVTDHWATMTLSGPNSRKLLGEVTDIDISNEAFPFMTWKEGLVGGVPARVFRISFTGELSYEVNVQADYAMGVLEKIVDAGKKYNLTPYGTETMHVLRAEKGFIIVGQDTDSSMTPDDLNMGWCVGRTKPFSWIGWRGMNREDCVRDQRKQLVGLKPIDPTKWLPEGAQLVFNTKQTIPMTMVGHVTSSYLHNSLGYSFAMGVVKGGLKRIGERVFAPLADGSVIEAEIVSSVFFDPKGDRQNV
>NZ_CP014870|6282764:6331603|6308400_6309621_-|WP_064680173.1|DBSCAN-SWA
MSDIIRRDPRAEWIARNRLHPLHAAMQPVQHSWMGPNGVIRKNPHGIGFIGPNGIKRIDRSGAQQGGASKRSAAVEVQLPLHQVPAPAFYISVVPDMVGGRLSSHDRDLLGLAHQLAGKDGAVLAVVFGEHKENAFATAGVDRLLVLDGEEFSGYAPEQRVQGLRAVDNQFSPRHWLLPDSRTGGGELGRRFAAALGERPATRVWQVKDEACIGRAGAGLQDLARPVARLILAAVECAEPVSETRHEALPVELSTTVARSLSRIEDLGAVAVDPAAIPMAEAEFIFSGGNGVKDWALFHSTAEALGATEGASRVAVDDGFMARDRQVGASGTWVTARVYVAVGISGAIQHLQGIGACDKVVAINLDPGCDMIKRADLSVIGESAEILQALIAAVEAYRNEAKRDAA
>NZ_CP014870|6282764:6331603|6288333_6289407_+|WP_082930439.1|DBSCAN-SWA
MTARREIPLCHYRYDPLDQLISCAMSAQANTQRFYLKDRLANEVQGAVQRSIMQHGDQLLAEQRCEGGPLETTIIATDQQRSVLTTLDSTRPHTLAYTPYGHRIPENGLLSLLGFSGERPDPVTGCYLLGNGYRAFNPVLMRFNSPDSWSPFGDGGLNAYTYCVGDPINREDKTGHVPNWFSKIKALMTRGNGFKRLSSTSLDSARSMVSTKSALATGSATPHATAGTLLPGLDPSSTSRNATTTASNSTPSASGVWDVKNTLYDANSAIESAQLKKYSGSKLKSLKKAAKKLEHYDNNKERLLSKLKNRQENLIEYGLVKPENLPTPQQLALEKINEQRKSVIFLTDELNKKLRGT
>NZ_CP014870|6282764:6331603|6302148_6302973_+|WP_064680168.1|DBSCAN-SWA
MSLQGKTLFITGASRGIGREIALRAARDGANIVIAAKSAEPHPKLPGTIFSVAKEVEAAGGKALALQVDVRDEVAVHEALARANEHFGGIDALVNNAGAIKLTGVQHIELKRFDLMHQINTRAVLLCSQAALPYLKKSSGHILNLSPPLNLASKWFAQYSPYTVTKYGMSMLTVGMSEEFKHYGISVNSLWPQTMIATAAIEFQLGSRESFKHARTPAIMADAAHVILDSSERSITGRLLIDEEILREHGVTEFDHYRFEPGTNDKLMPDLFID
>NZ_CP014870|6282764:6331603|6304491_6305787_+|WP_064680170.1|DBSCAN-SWA
MDVTAKISLGDPLEPARKATAQMLQERERTFSLPQPFYSDERLFDIDMQEIFQKEWLIAGMTCEIPTKGNYLTLQIGKNPIIVIRGAEGVVHAFHNVCRHRGSRLCTSEKGKVAKLVCHYHQWTYELDGRLLFAGTEMGADFDMKQYGLKPVNVKTAGGYIFISLSENPPAIDDFLATLNHYMEPYDMENTKVAITTTLMEKANWKLVLENNRECYHCNASHPELLKTLLEWDDVTDPRADQAFKDHVAASAAAWEAEKIPYAHASFGLRNRIVRMPLLKGTVSMTLDGKQGCAKLMGRIKNPDLGSMRILHLPHSWNHCMGDHIIVFTVWPISAQETMVTTKWVVHKDAVEGVDYDVERMRQVWDATNDQDRRLAEENQRGINSTAYQPGPYSKTYEFGVVNFVDWYSERLLNNLGAEPAPYLKGVPVQG
>NZ_CP014870|6282764:6331603|6290085_6290577_+|WP_064680159.1|DBSCAN-SWA
MRSTITASLLITLMTIGNAYAASSACPAVSDIIQVKDEQEGGYEYFAPGPDKRVWVGSNPYAEEHHIETFEFTGGLYRDISSEGNKFVVSCDYEGEEFLAFTRLTLYSFNDWKPATHTLWKREVNKQALLNNKNAQHVETCTSKDQEKCVFEYSSLSAAPSKK
>NZ_CP014870|6282764:6331603|6296877_6297207_-|WP_007907563.1|DBSCAN-SWA
MLHIFCPHCGELRSEEEFHASGQAHIPRPLDPNSCTDEEWGDYMFFRDNPRGLHHELWDHVAGCRQYFNVTRDTVTYEILETYKIGTKPQFTDKTDSPKAAATALGEKV
>NZ_CP014870|6282764:6331603|6316604_6317576_-|WP_064680178.1|DBSCAN-SWA
MKLRKNIRSLSSVEKQKFVAACLQLKASGQYDRYVHQHHHVMVPTVLPHEPNDPNYRNGAHRGPSFLPWHRAFLLQFEADLQAIDSSITIPYWDWTQDFADPLNSPVWKDDFMGGNGVESDEWRVASGPFAYKNGEWPVPSYPDDGLPGPGLKRQFSLVVNSLPTPEDLQMAMRESLYDTPPYDSSHCVRGFRNRLEGWITQRGDPQVTTSSSQLHNRVHLWVGGNMLPMTSPDDPVFFLHHCFVDKVWADWQARMVRDNGQWAPHYAPLQNGPEGHNYHDVLKPWTLKISEVMDIDALDYEYEQAADSLVVPQRVNQLPCLA
>NZ_CP014870|6282764:6331603|6285719_6286280_-|WP_064680156.1|DBSCAN-SWA
MKISRGFALASLMTLAASPVFAQFSFSDAANAISGMKGDNTAATAAPTSETAGLLSALSQLNVTPQQAVGGTSAMLGLAKNQLSSTDYSELAKSVPGIDKLSGGGELGALAGLLGSSGKMAGLDNALGAVKSTNDLNNAFSALGMDTGMIAQFAPLILQYFGQQGVGGSLLQSLGGIWGAGTGIGS
>NZ_CP014870|6282764:6331603|6321571_6322537_+|WP_064680183.1|DBSCAN-SWA
MTFITEIKTFAALGSGVIGSGWVSRALAHGLDVVAWDPAPGAEAALRKRVANAWGALEKQGLAPGASQDRLRFVATIEECVRDADFIQESAPERLDLKLELHSKISAAAKPDALIGSSTSGLLPSEFYESSTHPERCVVGHPFNPVYLLPLVEVVGGKNTAPEAVQAAMKVYESLGMRPLHVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGLRWSFMGTFLTYTLAGGDAGMRHFMAQFGPALQLPWTYLPAPELTDKLIDDVVDGTSDQLGTHSISALERYRDDCLLAVLEAVKTTKEKHGMAFAE
>NZ_CP014870|6282764:6331603|6306875_6307442_-|WP_064680171.1|DBSCAN-SWA
MTVEFRSAVRADAREIARLFQITSEGAADYIWSQLAQPGQDLLDVGATRYARDDVDFSWQNCLIAQANDEVIGMMHSYVMRHDPLAEPTTDPVLAPYATMEIPDTLYISSLALHEGWRNQGLGKQFLAYAYDRANQLGLNGLSLIDYAANTGARRFYERNGFRIVDTCQITPHPMIRVTGEAYLMYRP
>NZ_CP014870|6282764:6331603|6300032_6300749_-|WP_064680166.1|DBSCAN-SWA
MHMTQRDGALDLLKWLALLSMVLDHLRYIGYSVDILYVPGRLAFPWFCLAMAANLSRARSVTTDGHWRYLGWLLLFSAVSEMPYRMFIPDPDTFNVLPTLALGLLVARGWQQPLLQSRLLAAAALVLAALFPERLMFGFFGVLLPLVTLLVIRRPWYFNLLPGLICLAANQWEVLYYSARFGNRAAILGIAVCLIAPLLGMVLLRHAGHFKLPPMRRWAYALYPLHFLLLLLIRKLAA
>NZ_CP014870|6282764:6331603|6330424_6331603_+|WP_064680190.1|holin|DBSCAN-SWA
MSIIRFDNVDVIFSKDPREALKLLDQGMTRNEILKKTGQIVGVEKASLDVEKGEICVLMGLSGSGKSSLLRCINGLNTVSRGKLFVEHEGKQIDIASCTPAELKMMRTKRIAMVFQKFALMPWLTVRENISFGLEMQGRPEKERRKLVDEKLELVGLTQWRNKKPNELSGGMQQRVGLARALAMDADILLMDEPFSALDPLIRQGLQDELLELQRKLSKTIVFVSHDLDEALKLGSRIAIMKDGRIIQYSKPEEIVLNPADDYVRTFVAHTNPLNVLCGRSLMRTLDNCKRINGSVCLDPGGDSWLDLAEGNTIKGARQNGASLDLQNWIPGQAVEGLGRRPTLVDSNIGMRDALQIRYQTGNKLVLHDNNKVVGILGDSELYHALLGKNLG
>NZ_CP014870|6282764:6331603|6325129_6326233_-|WP_046029844.1|DBSCAN-SWA
MTTFNSGAQPQNRAPQSIGFLLLDNFTLISLASAVEPLRMANQLSGRELYRWTTITVDGGQVWASDGLQITPDCSMHKAPALDTIIVCGGIGIQRTVTREHVSWLQSQARQSRRLGAVCTGSWALACAGLLDGFDCSVHWECLASMQEAFPRVAMSTRLFTLDRNRFTSSGGTAPLDMMLHLISRDHGRELSAAISEMFVYERIRNEQDHQRVPLKHMLGTNQPKLQEIVALMEANLEEPIDLDELAVYVAVSRRQLERLFQKYLHCSPSRYYLKLRLIRARQLLKQTPMSIIEVASVCGFVSTPHFSKCYREYFGIPPRDERVGSNTTQQVAMMPLPQALVLSPLSGPLSALSQARNESTFASVRL
>NZ_CP014870|6282764:6331603|6318355_6319315_-|WP_064680180.1|DBSCAN-SWA
MSQDFYFLLMPGFSAIGFISAIEPLRVANRFRGELYRWHVLSADGGAVLASNGMSVNADAALEPLKKGATLLVVAGFEPLKFATPALEHWLRRLDNEGVTLGAIDTGSFVLAEAGLLDGHRLTLHWEAIDAFKESYPQLSVTQELFEIDRRRITSAGGTASIDLMLDLIAQAHGPALAIQVSEQFVLGRIRPRKDHQRMEVATRYGISNKKLVHVIGEMEQHSEPPLSTLELAESIKVTRRQLERLFRLHLNDTPSNFYLRLRLEKARQLLRQTDMSVLEVSIACGFESPSYFARSYRARFARCPREDRRRLGDGRELV
>NZ_CP014870|6282764:6331603|6297221_6298472_-|WP_064680164.1|DBSCAN-SWA
MQRYSGFGLFKHSLSHHENWQRMWRTPTPKKVYDVVIVGGGGHGLATAYYLAKEHGITNVAVVEKGWLGGGNTARNTTIVRSNYLWDESAHLYEHAMKLWEGLSQDLNYNVMFSQRGVYNLCHTLQDIRDSERRVSANRLNGVDGELLDAKQVADEIPYLDCSKNTRYPVMGATVQRRGGVARHDAVAWGFARAADALGVDLIQQTEVIGFRKENGVCIGVETNKGFIGGKRVGVVTAGNSGHMAKLAGFRLPIESHPLQALVSEPIKPIIDSVIMSNAVHGYISQSDKGDLVIGAGIDGYNGYGQRGSYPVIEHTVQAIVEMFPVLSRVRMNRQWGGIVDTTPDACPIISKTPVPNMFFNCGWGTGGFKATPGSGNVFAASLAKGEMHPLAAPFSIDRFHNGALIDEHGAAAVAH
>NZ_CP014870|6282764:6331603|6323180_6324344_+|WP_064680185.1|DBSCAN-SWA
MNTAAAFADFRTYPLISALAGVQALTDRVLVKWADDRVSPFHHQWLRDNCPCPLCVYTVTREQVLEIVDVEENLLPAETSVDAEGCLCVAWQDGHRSRFDPGWLRAHAYDDESRAERRAGKPQARLWNSDLQLPVFDYAALMNDNDALLQWLLAVRDIGLTQVRGVPTEPGSLKLIAQRISFIRESNFGVLFNVQSKADADSNAYTAFNLPLHSDLPTRELQPGLQFLHCLVNDAEGGESIFVDGFAIADALRQEDPEAFQALCEIPVEFRNKDRHSDYRRLAPIIALDASGQVSEIRMANFLRGPFDAAVEQMPKLYRAYRRFIAMTREPRFRLMQRLNPGELWCFDNRRTLHARNAFDPATGARHFQGCYVDRDELLSRILVLQR
>NZ_CP014870|6282764:6331603|6309620_6311573_-|WP_064680174.1|DBSCAN-SWA
MLNTLLPILLFAALGLAVLGALRRVAMWRRGRASKVDLIGGLFAMPKRYMVDLHHVVARDKYIANTHVATAGGAVASIVLAILVHGFGLHNRILGYALLLMTAVMFVGAIFVYLRRRNPPARLSKGPWMRLPKSLLAFSVSFFLLTLPVAGILPENFGGWVVAAILGVGVLWGVSELFFGMTWGGPMKHAFAGALHLAWHRRAERFGGGRSTGLKPLDLNDPNAPLGVEKPKDFTWNQLLGFDACVQCGKCEAACPAFAAGQPLNPKKLIQDMVVGLAGGTDAKFAGSPYPGKPIGEHAGNPHQPIVNGLVDAETLWSCTTCRACVEECPMMIEHVDAIVDMRRHLTLEKGATPNKGAEVLENLIATDNPGGFAPGGRMNWAADLNLDLLSEKKSVDVLFWVGDGAFDMRNQRTLRAFVKVLKAAKVDFAVLGLEERDSGDVARRLGDEATFQLLAKRNIQTLAKYSFNRIVTCDPHSFHVLKNEYGAFDGNYLVQHHSTYMAEIIGAGALNLGQHKGSSVTYHDPCYLGRYNGEYEAPREVLRALGIEVKEMQRSGFRSRCCGGGGGAPITDIPGKQRIPDMRMEDIRETGAELVAVGCPQCTAMLEGVVEPRPLIKDIAELVADALLEDAAPSKPNAPAKREEPAEAH
>NZ_CP014870|6282764:6331603|6329582_6330428_+|WP_064680189.1|holin|DBSCAN-SWA
MLIDQKIPLGQYIAGFVEWLTQNGASTFDAIAVSLETMIHGVTFALTWFNPLALIGLIALLAHFIQRKWGLTVFVIASFLLILNLGYWQETMETLAQVLFATLVCVLIGVPLGIVAAHKPMFYTVMRPVLDLMQTVPTFVYLIPTLTLFGLGVVPGLISTVVFAIAAPIRLTYLGIRDVPEELMDAGKAFGCSRRQLLSRIELPHAMPSIAAGITQCIMLSLSMVVIAALVGADGLGKPVVNALNTADIALGFEAGLAIVLLAIMLDRICKQPEAKVGGDA
>NZ_CP014870|6282764:6331603|6284830_6285718_+|WP_064680155.1|DBSCAN-SWA
MRRLLTGCFVTLLLLLNTLALFGPLMVFALLKLVLPGRFRDYASWAVMWIAETWAEIDKLIFQLCIPTRWDIRGGDDLRRDTSYLVIGNHQSWVDIPALIQTLNRRTPFFKFFLKKELIWVPFLGLAWWALDYPFMKRYTKAFLAKNPELAGKDLEITKAACELFKRQPVTVVNYLEGTRFTAAKSRLQQSPFTHLLKPKAGGVAFVLAAMGEQLDAVLDVTVVYPQQQIPGFWDLISGNVPRVIIDIKTRELDPALWQGDYENDPVFRQTVQNWVNQLWIEKDRRIDALRAERP
>NZ_CP014870|6282764:6331603|6319522_6320467_+|WP_064680181.1|holin|DBSCAN-SWA
MKRLISSCVLALSGTALLSASVMAAEPASCQNVRMGVVNWTDVIATSAMTQVLLDGLGYNTKQTSASQQIIFAGIRDQRLDLFLGYWNPLMTQTITPFVQANQVKVLEAPSLKDARATLAVPTYLADKGLKTFADIAKFQKELGGKIYGIEPGSGANTQIKAMIAKNQFGLGKFQLVESSEAGMLAAVDRAVRRKEAVVFFGWAPHPMNVNVQMTYLTGSEDALGPNEGMATVWTVTSPNYAQQCPNIGRLLSNLTYTAEDESRMMQPLLEHKDAFESAKQWLKDHPQDKQRWLEGVTTFDGKPAADNLKLTTQ
>NZ_CP014870|6282764:6331603|6320541_6321429_+|WP_064680182.1|DBSCAN-SWA
MNHDVIITCALTGAGDTTARSPHVPVTPKQIAAAAVEAAKAGATVVHCHVRDPQTGKFSRDVALYREVMERIREADVDIIVNLTAGMGGDLEIGAGENPMEFGPNTDLVGPLTRLAHVEELLPEICTLDCGTLNFGDGDTIYVSTPAQLRAGAKRIQELGVKAELEIFDTGHLWFAKQMIKEGLLDNPLFQLCLGIPWGAPADTTTMKAMVDNLPADAVWAGFGIGRMQMPMAAQAVLLGGNVRVGLEDNLWLDKGVLATNGQLVERASEILSRLGARVLTPAEGRTKMGLTKRG
>NZ_CP014870|6282764:6331603|6293097_6293730_-|WP_064680162.1|DBSCAN-SWA
MTAANVYQQRPTTGAKAESSLHHADLASLVGKGRKSAGVIVREKKLLGHLTIRGDGHDAAFAAGVQKALGIELPGALTVIVKGETSLQWMGPDEWLLIVPSGEEFAAEQKLRKALGDLHIAIVNVSGGQQLLELSGPNVRQVLMKSTSYDVHPNSFPVGKAVGTVFAKSQLMIRHTAEDTWELLIRRSFSDYWWLWLQDASAEFGLSVQA
>NZ_CP014870|6282764:6331603|6314446_6315424_-|WP_008033250.1|DBSCAN-SWA
MSPAELHADSIVIDGLIIAKWNRELFEDMRKGGLTAANCTVSVWEGFQATVNNIAASQKLIRENSDLVIPVRTTADIRKAKEQGKTGILFGFQNAHAFEDQIGYVEVFKQLGVGIVQMCYNTQNLVGTGCYERDGGLSGFGREIVAEMNRVGVMCDLSHVGSKTSEEVILESKKPVCYSHCLPSGLKIHPRNKSDEELKFIADHGGFVGVTMFAPFLAKGIDSTIDDYAEAIEYTMNIVGEDAIGIGTDFTQGHGQDFFEYLTHDKGYARRLTSFGKIINPLGIRTVGEFPNLTETLLKRGHSERVVRKIMGENWVNVLKDVWGE
>NZ_CP014870|6282764:6331603|6283401_6284627_-|WP_102136402.1|transposase|DBSCAN-SWA
MFMTNSNDKSGELLGQERRRRWSPEQKLAMVRESLEPGQSVSVVARRNGINANQLFLWRKLYQDGSLSAVSAGEAVVPASELSDALKQIRELQRMLGKKTMEAEILKEAVEIARSRKLDCALTLVAGGRPVKLVSECLGVARSQLTVRIKQSVSPKVRRSRPVNDVELVAEIQQEVSELPSYGYRRVWGLLRRAREKRSLPAINVKRVYRVMRDHNLLLERRIKQPGVPRRHEGRIAVKTSDTRWCSDGFEFRCEDGAKLSVTFALDCCDREAIGWVASPTGYSGDDIRDLMLESVEKRFGDQLPTTPVQWLSDNGSAYTAEQTRLFARQIGLQPVTTPVRSPQSNGMAESFVKTIKRDYVAHMPKPDRETALRNLAIAFEHYNEQHPHSALNYRSPREFRRLAAASI
>NZ_CP014870|6282764:6331603|6326756_6328133_-|WP_064680187.1|DBSCAN-SWA
MAISVFDLFKIGIGPSSSHTVGPMRAAALFVQGMREQGLVEQVRRIEVQLYGSLSATGIGHGSDNAVIMGLMGEWPDAIDPSQIGLHIATLRETDTLLLDGRLPVPFIWARDMRLIDENLPFHPNAMTLVAEGDDGELHRDTYYSIGGGFVVDEAQASSGVVDLDRTVLPYDFSSAAELLSLCKQHDLRVAELMMANEKVWRSEEEIRTGLMKLWRAMQDCVEQGLKHEGILPGGLNVRRRAAKLHRSLQELNKPNVIGSTLSAMEWVNLFALAVNEENAAGGRMVTAPTNGAAGIIPAVLHYFMKFSEAVTDANVVDYFLSAAAVGILCKKNASISGAEVGCQGEVGSACAMAAAGLAEILGATPEQLCNAAEIGLEHNLGLTCDPVGGLVQVPCIERNAIAAVKAINAAQMALRGDGQHFISLDRVIRTMRDTGADMHDKYKETSRGGLAVSAVEC
>NZ_CP014870|6282764:6331603|6315648_6316050_+|WP_064680176.1|DBSCAN-SWA
MKSIFLALALIATGAQAAEEADDNPCDAVENEIQTLECSAYSRTTAEDLLSENYKSLTERLQMLYGKTPAQLTDVTAKLKAAQQQWLKTRDADCTVEAFPATSGSKAFTIAQNDCVARMSDERSEFLESIGQE
>NZ_CP014870|6282764:6331603|6286537_6287644_+|WP_082930438.1|DBSCAN-SWA
MTARREIPLCHYRYDPLDQLISCATSAQANTQRFYLKDRLANEVQGAVQRSIMQHGDQLLAEQRCEGGPLETTILATDQQRSVLTTLDSTRPHTLAYTPYGHRIPENGLLSLLGFSGERPDPVTGCYLLGNGYRAFNPVLMRFNSPESLSPFGEGGLNAYAYCVGDPINRVDPTGHVGEWISKLLGFLNNASGTVAVNQSVSKSRYMKNMTILGDGAFTFDDIFKGKQRLNISAHGIETPFDQPSKMVMNRETWLPSQVYTEMKNQGYDFSSYAEIRLIFCHSANGGQQSFASQFQKLTNINTKGYLGTVVEKHPIDDVMKVFEKGKIKYPDNPQKYLREHYNKEKSYTYKKRYGLIAVNYHSVRFPS
>NZ_CP014870|6282764:6331603|6300872_6301913_+|WP_064680167.1|DBSCAN-SWA
MTDKSQQFASDNYSGICPEAWAAMEQANHGHQRAYGDDEWTARAADQFRKLFETDCEVFFAFNGTAANSLALSSLCQSYHSVICSETAHVETDECGAPEFFSNGSKLLVARTENGKLTPESIREIALKRQDIHYPKPRVVTLTQATEVGSVYTPEEIRAISVTCKELGLNLHMDGARFSNACAFLGCSPADLTWKAGVDVLCFGGTKNGMAVGEAILFFNHKLAEDFDYRCKQAGQLASKMRFLSAPWVGILENDAWLNYARHANHCAQLLAELVSDIPGVELMFPVQANGVFLQLSEPAIAALTAKGWRFYTFIGNGGARFMCSWDTEEERVRELATDIREVMAR
>NZ_CP014870|6282764:6331603|6298495_6299749_-|WP_064680165.1|DBSCAN-SWA
MFSKQDQIKGYDDALLAAMNAEEQRQEDHIELIASENYTSKRVMEAQGSGLTNKYAEGYPGKRYYGGCEHVDKVEALAIERAKQLFGADYANVQPHSGSSANSAVYLALLQAGDTILGMSLAHGGHLTHGAKVSSSGKLYNAVQYGIDTKTGLIDYDEVERLAVECKPKMIVAGFSAYSKTLDFPRFRQIADKVGALLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLILCKSNEEIEKKLNAAVFPGAQGGPLMHVIAGKAVCFKEALEPGFKAYQQQVIDNAQAMAGVFIKRGYDVVSGGTDNHLFLVSLIRQGLTGKEADAALGRAHITVNKNAVPNDPQSPFVTSGLRIGTPAVTTRGFKVTQCVELAGWICDILDNLGDADVEANVAQQVSALCADFPVYR
>NZ_CP014870|6282764:6331603|6328568_6329516_+|WP_064680188.1|holin|DBSCAN-SWA
MKGSPPLLLAAMLSLPFLAQAAEPAQCKTVNFSDVGWTDITVTTATTSVVLDALGYKTKTTMISVPVTYKSLADGKNMDVFLGNWMPTMENDIKAYRDAGTVDTLRANLENAKYTLAVPEELYNKGLKDFADIAKFKKELDGKIYGIEPGNDGNRLIQSMIDKNAFGLKDAGFKVVESSEAGMLSQVDRAQRRNTAVVFLGWEPHPMNTRFKMKYLTGGDDFFGPNFGQATIFTNTRKGYAQECSNVGQLLKNLVFTLDMESTLMGNVLDDKMKPDAAAKAWLKKNPQVLDTWLAGVTTIDGKPGLEAVKAKLAQ
>NZ_CP014870|6282764:6331603|6322664_6323141_+|WP_064680184.1|DBSCAN-SWA
MPTLTTYQTTIIPDWVDYNGHLRDAFYLLIFSYATDALMDRLGMDSNNREASGNSLFTLELHLNYLHEVKLDAEVEVHTQIIGHDSKRLHLYHSLHLVGDDKELAGNEQMLLHVDLAGPRSAPFSEETLSKLQAMVAEQADLPAPACIGRVIALPPAK
>NZ_CP014870|6282764:6331603|6311761_6313822_-|WP_064680175.1|DBSCAN-SWA
MAFEAMFQPIQIGKLTIRNRVLSTAHAEVYATDGGMTTDRYIKYYEEKAKGGIGLAICGGSSVVAIDSPQEWWSSVNLSTDRIIPHFQNLADAMHKHGAKIMIQITHMGRRSRWDGFNWPTLMSPSGVREPVHRATCKTIEPEEIWRVIGNYAQAARRAKAGGLDGVELSAVHQHMIDQFWSPRVNKRTDEWGGSFENRMRFGLEVLKAVRAEVGPDFCVGIRLCGDEFHPDGLSHEDMKQIAKYYDDTGMLDFIGVVGSGCDTHNTLANVIPNMSYPPEPFLHLAAGIKEVVKAPVLHAQNIKDPNQATRILEGGYVDMVGMTRAHIADPHLIAKIKMGQIDQIKQCVGANYCIDRQYQGLDVLCIQNAATSREYMGLPHIIEKTTGVKRKVVVVGAGPAGMEAARVAAERGHDVTLFEKKEFIGGQITTASKAPQRDQIAGITRWYQLELARLKVDLRLGVAADAPTILDLRPDVVVLAVGGHSYLEQNEHWGAAEGLVVSSWDILDGKVAPGKNVLVYDTICEFTGMSAADFLADKGSQVEIVTDDIKPGVAIGGTSFPTYYRSMYPKEVIMTGDMMLEKVYREGDKLIAVLENEYTGAKEERVVDQVVVENGVRPDEEIYYAMKEGSRNKGQIDVEALFAIKPQPSLSQPGDGYLLFRIGDCVAQRNIHAAIYDALRLCKDF
>NZ_CP014870|6282764:6331603|6317801_6318218_+|WP_064680179.1|DBSCAN-SWA
MNICGIEIKGSEAIIAVASLDDQVLSHVALSTKKIALDDDDEAANVKVFAAQVASFVREHSIDRIAIKKRSKKGEFAGGPTTFKIEGIFQLLENCEVTLLSPQTINAQNKKFDFALPATLNKYQHEAFKAACSALMKK
>NZ_CP014870|6282764:6331603|6290677_6291877_-|WP_064680160.1|DBSCAN-SWA
MSGNRGVVYLGNGQVEIQKIDYPKMQDPRGRKINHAVILRVVSTNICGSDQHMVRGRTTAQTGLVLGHEITGEVIEKGSDVENLQIGDLVSVPFNVACGRCRSCKEMHTGVCLSVNPARPGGAYGYVDMGDWTGGQAEYAMVPYADFNLLKLPDRDRAMEKIRDLTCLSDILPTGYHGAVTAGVGPGSTVYIAGAGPVGLAAAASARLLGAAVVIIGDVNTVRLAHAKAQGFEIADLSLDTPLHEQIAALLGEPEVDCAVDAVGFEARGHGHDGVKHEAPATVLNSLMGVVRVAGKIGIPGLYVTEDPGAVDAAAKMGSLSIRFGLGWAKSHSFHTGQTPVMKYNRQLMQAIMWDRIHIADIVGVEVISLDDAPRGYGEFDAGVPKKFVIDPHKLFSAA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_064680154.1|6282764_6283271_-|protease	ATP-dependent zinc protease	NA	NA	NA	NA
WP_102136402.1|6283401_6284627_-|transposase	IS3 family transposase	A0A1B0Z042	Pseudomonas_phage	5.2e-158	94.8
WP_064680155.1|6284830_6285718_+	acyltransferase	NA	NA	NA	NA
WP_064680156.1|6285719_6286280_-	DUF2780 domain-containing protein	NA	NA	NA	NA
WP_082930438.1|6286537_6287644_+	RHS repeat-associated core domain-containing protein	B6SD27	Bacteriophage	4.1e-29	42.0
WP_082930439.1|6288333_6289407_+	RHS repeat-associated core domain-containing protein	B6SD27	Bacteriophage	2.9e-27	40.8
WP_064680159.1|6290085_6290577_+	DUF3757 domain-containing protein	NA	NA	NA	NA
WP_064680160.1|6290677_6291877_-	formaldehyde dehydrogenase, glutathione-independent	A0A2K9L7I1	Tupanvirus	1.3e-09	27.0
WP_064680161.1|6292083_6292941_-	formyltetrahydrofolate deformylase	NA	NA	NA	NA
WP_064680162.1|6293097_6293730_-	sarcosine oxidase subunit gamma family protein	NA	NA	NA	NA
WP_064680163.1|6293863_6296881_-	sarcosine oxidase subunit alpha	NA	NA	NA	NA
WP_007907563.1|6296877_6297207_-	sarcosine oxidase subunit delta	NA	NA	NA	NA
WP_064680164.1|6297221_6298472_-	sarcosine oxidase subunit beta family protein	NA	NA	NA	NA
WP_064680165.1|6298495_6299749_-	serine hydroxymethyltransferase	A0A240F3L3	Aeromonas_phage	6.0e-101	53.2
WP_064680166.1|6300032_6300749_-	conjugal transfer protein TraX	NA	NA	NA	NA
WP_064680167.1|6300872_6301913_+	low specificity L-threonine aldolase	NA	NA	NA	NA
WP_064680168.1|6302148_6302973_+	NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_064680169.1|6303108_6304209_-	glycine-betaine demethylase subunit GbcB	NA	NA	NA	NA
WP_064680170.1|6304491_6305787_+	glycine-betaine demethylase subunit GbcA	NA	NA	NA	NA
WP_064680171.1|6306875_6307442_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_064680172.1|6307614_6308385_-	electron transfer flavoprotein subunit beta	NA	NA	NA	NA
WP_064680173.1|6308400_6309621_-	electron transfer flavoprotein subunit alpha/FixB family protein	NA	NA	NA	NA
WP_064680174.1|6309620_6311573_-	dimethylglycine demethylation protein DgcB	NA	NA	NA	NA
WP_064680175.1|6311761_6313822_-	dimethylglycine demethylation protein DgcA	NA	NA	NA	NA
WP_008033249.1|6313837_6314368_-	4-vinyl reductase	NA	NA	NA	NA
WP_008033250.1|6314446_6315424_-	membrane dipeptidase	NA	NA	NA	NA
WP_064680176.1|6315648_6316050_+	DUF1311 domain-containing protein	NA	NA	NA	NA
WP_064680178.1|6316604_6317576_-	tyrosinase family protein	NA	NA	NA	NA
WP_064680179.1|6317801_6318218_+	DUF3010 family protein	NA	NA	NA	NA
WP_064680180.1|6318355_6319315_-	GlxA family transcriptional regulator	NA	NA	NA	NA
WP_064680181.1|6319522_6320467_+|holin	choline ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_064680182.1|6320541_6321429_+	3-keto-5-aminohexanoate cleavage protein	NA	NA	NA	NA
WP_064680183.1|6321571_6322537_+	L-carnitine dehydrogenase	NA	NA	NA	NA
WP_064680184.1|6322664_6323141_+	thioesterase family protein	NA	NA	NA	NA
WP_064680185.1|6323180_6324344_+	gamma-butyrobetaine dioxygenase	NA	NA	NA	NA
WP_064680186.1|6324746_6325010_+	hypothetical protein	NA	NA	NA	NA
WP_046029844.1|6325129_6326233_-	GlxA family transcriptional regulator	NA	NA	NA	NA
WP_064680187.1|6326756_6328133_-	L-serine ammonia-lyase	NA	NA	NA	NA
WP_064680188.1|6328568_6329516_+|holin	choline ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_064680189.1|6329582_6330428_+|holin	choline ABC transporter permease subunit	NA	NA	NA	NA
WP_064680190.1|6330424_6331603_+|holin	choline ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	3.8e-25	37.1