CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP016352	Vibrio natriegens strain CCUG 16374 chromosome 2, complete sequence	1 crisprs	cas6f,cas7f,cas5f,DEDDh,csa3,cas3	0	2	1	0
NZ_CP016351	Vibrio natriegens strain CCUG 16374 chromosome 1, complete sequence	1 crisprs	cas3,WYL,DinG,csa3,csx1,DEDDh	1	1	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP016352_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016352_1

844652-844862

Unclear

Consensus_repeat	Method
ATTATCAGCTACCTATGCGGCAGTTCACT	CRT
AATTATCAGCTACCTATGCGGCAGTTCACTAT	PILER-CR
ATTATCAGCTACCTTTGCGGCAGTTCACT	CRISPRCasFinder

3 spacers

cas6f,cas7f,cas5f

The CRISPR arrays of NZ_CP016352_1

>merge|NZ_CP016352|1|844652-844862|CRT,PILER-CR,CRISPRCasFinder
GATCCTCTCTACCTATACGGCAGTTCACATCGTGGTTGCTCTTGAAGAAGATTATGAACAATTATCAGCTACCTTTGCGGCAGTTCACTCTACTCTACGGTTTCTTGCTCTTGCCTCATCATTATCAGCTACCTATGCGGCAGTTCACTTTGCTATCTCTGGGATGATTGAATTACCTAAATTATCAGCTACCTATGCGGCAGTTCACTAT

>NZ_CP016352|1|1|844652-844860|CRT
GATCCTCTCTACCTATACGGCAGTTCACA	TCGTGGTTGCTCTTGAAGAAGATTATGAACA
ATTATCAGCTACCTTTGCGGCAGTTCACT	CTACTCTACGGTTTCTTGCTCTTGCCTCATC
ATTATCAGCTACCTATGCGGCAGTTCACT	TTGCTATCTCTGGGATGATTGAATTACCTAA
ATTATCAGCTACCTATGCGGCAGTTCACT

>NZ_CP016352|1|1|844711-844862|PILER-CR
AATTATCAGCTACCTTTGCGGCAGTTCACTCT	ACTCTACGGTTTCTTGCTCTTGCCTCAT
CATTATCAGCTACCTATGCGGCAGTTCACTTT	GCTATCTCTGGGATGATTGAATTACCTA
AATTATCAGCTACCTATGCGGCAGTTCACTAT

>NZ_CP016352|1|1|844712-844860|CRISPRCasFinder
ATTATCAGCTACCTTTGCGGCAGTTCACT	CTACTCTACGGTTTCTTGCTCTTGCCTCATC
ATTATCAGCTACCTATGCGGCAGTTCACT	TTGCTATCTCTGGGATGATTGAATTACCTAA
ATTATCAGCTACCTATGCGGCAGTTCACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016352.1\|WP_065298161.1\|849972_850959_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|367112
NZ_CP016352.1\|WP_065298162.1\|851125_852082_+\|sensor-domain-containing-diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP016352.1\|WP_065298158.1\|845590_846634_-\|type-I-F-CRISPR-associated-protein-Csy3	cas7f	cd09677_cas7f_CAS-I-F	gnl\|CDD\|274205
NZ_CP016352.1\|WP_014234862.1\|836364_837255_+\|maltose-ABC-transporter-permease-MalG	unknown	unknown	gnl\|CDD\|182891
NZ_CP016352.1\|WP_065298157.1\|844990_845587_-\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	cas6f	cd09674_cas6f_CAS-I-F	gnl\|CDD\|187805
NZ_CP016352.1\|WP_065298166.1\|858954_859812_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NZ_CP016352.1\|WP_065298155.1\|842218_843592_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|223989
NZ_CP016352.1\|WP_065298159.1\|846605_848549_-\|CRISPR-associated-protein-Csy2	cas5f	cd09736_cas5f_CAS-I-F	gnl\|CDD\|187867
NZ_CP016352.1\|WP_031779247.1\|837691_837937_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016352.1\|WP_014234860.1\|838096_838582_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|224523
NZ_CP016352.1\|WP_065298156.1\|844238_844445_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP016352.1\|WP_065298154.1\|841225_842185_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|377533
NZ_CP016352.1\|WP_014234863.1\|834777_836352_+\|maltose-ABC-transporter-permease-MalF	unknown	unknown	gnl\|CDD\|236816
NZ_CP016352.1\|WP_155759774.1\|843591_844128_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016352.1\|WP_065298163.1\|852757_854713_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016352.1\|WP_065298153.1\|839351_841229_+\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|366234
NZ_CP016352.1\|WP_065298165.1\|856579_858061_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP016352.1\|WP_065298167.1\|859995_868110_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375438
NZ_CP016352.1\|WP_065298160.1\|848549_849737_-\|TniQ-family-protein	unknown	unknown	gnl\|CDD\|377670
NZ_CP016352.1\|WP_065298152.1\|838707_839355_+\|endonuclease	unknown	unknown	gnl\|CDD\|378037

Protein	Function_ID	Function_description	E-value
NZ_CP016352.1\|WP_065298161.1\|849972_850959_+\|sensor-histidine-kinase	gnl\|CDD\|367112	pfam02518, HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	0.00306609
NZ_CP016352.1\|WP_065298162.1\|851125_852082_+\|sensor-domain-containing-diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	8.3391e-44
NZ_CP016352.1\|WP_065298158.1\|845590_846634_-\|type-I-F-CRISPR-associated-protein-Csy3	gnl\|CDD\|274205	TIGR02566, conserved_hypothetical_protein, CRISPR type I-F/YPEST-associated protein Csy3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family, typified by YPO2463 of Yersinia pestis, is a CRISPR-associated (Cas) family strictly associated with the Ypest subtype of CRISPR/Cas locus. This family is designated Csy3, for CRISPR/Cas Subtype Ypest protein 3.	5.27999e-115
NZ_CP016352.1\|WP_014234862.1\|836364_837255_+\|maltose-ABC-transporter-permease-MalG	gnl\|CDD\|182891	PRK10998, malG, maltose ABC transporter permease MalG.	0
NZ_CP016352.1\|WP_065298157.1\|844990_845587_-\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	gnl\|CDD\|187805	cd09674, Cas6_I-F, CRISPR/Cas system-associated RAMP superfamily protein Cas6f. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6f is an endoribonuclease that generates crRNA; This family is specific for CRISPR/Cas system I-F subtype; Possesses RRM fold; also known as Csy4 family.	1.92144e-64
NZ_CP016352.1\|WP_065298155.1\|842218_843592_-\|diguanylate-cyclase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	1.85582e-26
NZ_CP016352.1\|WP_065298159.1\|846605_848549_-\|CRISPR-associated-protein-Csy2	gnl\|CDD\|187867	cd09736, Csy2_I-F, CRISPR/Cas system-associated RAMP superfamily protein Csy2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; predicted Cas5 ortholog.	6.06347e-53
NZ_CP016352.1\|WP_014234860.1\|838096_838582_-\|acyl-CoA-thioesterase	gnl\|CDD\|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	7.43267e-59
NZ_CP016352.1\|WP_065298156.1\|844238_844445_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.16065e-13
NZ_CP016352.1\|WP_065298154.1\|841225_842185_+\|AAA-family-ATPase	gnl\|CDD\|377533	pfam05621, TniB, Bacterial TniB protein. This family consists of several bacterial TniB NTP-binding proteins. TniB is a probable ATP-binding protein which is involved in Tn5053 mercury resistance transposition.	5.53608e-22
NZ_CP016352.1\|WP_014234863.1\|834777_836352_+\|maltose-ABC-transporter-permease-MalF	gnl\|CDD\|236816	PRK10999, malF, maltose ABC transporter permease MalF.	0
NZ_CP016352.1\|WP_065298165.1\|856579_858061_-\|GGDEF-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.15834e-82
NZ_CP016352.1\|WP_065298153.1\|839351_841229_+\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	3.86858e-09
NZ_CP016352.1\|WP_065298166.1\|858954_859812_+\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	5.72125e-26
NZ_CP016352.1\|WP_065298167.1\|859995_868110_+\|hypothetical-protein	gnl\|CDD\|375438	pfam17936, Big_6, Bacterial Ig domain. This domain is found in a wide variety of extracellular bacterial proteins often in multiple tandem copies.	7.14986e-10
NZ_CP016352.1\|WP_065298160.1\|848549_849737_-\|TniQ-family-protein	gnl\|CDD\|377670	pfam06527, TniQ, TniQ. This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons.	2.83633e-19
NZ_CP016352.1\|WP_065298152.1\|838707_839355_+\|endonuclease	gnl\|CDD\|378037	pfam08722, Tn7_Tnp_TnsA_N, TnsA endonuclease N terminal. The Tn7 transposase is composed of proteins TnsA and TnsB. DNA breakage at the 5' end of the transposon is carried out by TnsA, and breakage and joining at the 3' end is carried out by TnsB. The N terminal domain of TnsA is catalytic.	6.13683e-13

>NZ_CP016352.1|WP_065298156.1|844238_844445_+|helix-turn-helix-transcriptional-regulator
MKDLAKKFGHNVRSMRKDKGISQDKLALTADIDRSYVGRIERGEVNITLEKAYQLAEVLRCDIRELLP
>NZ_CP016352.1|WP_155759774.1|843591_844128_-|hypothetical-protein
MSQGFTTHPYITDSIIKNNKDEFNISDIRDLLLASTMRDKSKGCVRMFVSKQLNIMVKQGMLTTSGNNRNKLFRKTQLFEQFNTSENEELEYQKANTGCVTKSSSYVDQLDKTRSRLNAELAMLIAEMDEYRSIIAQFPQTKEKVSKLHEESTQHSATLTGQITAISKTIEVLQSETV
>NZ_CP016352.1|WP_065298155.1|842218_843592_-|diguanylate-cyclase
MLREWQRNCIDGILERYTSGKKHFLTQATPGAGKTIMAAYLSKQLLDSNMIDLIVCFSPSVNVANGFTSTFSRVLQCSFNGSLGSLGTSLTYQAIQYLDDQFWETISKHRVLAIFDEIHHCSGETLSDANAWGEQIILKVQKASKYTLALTGTPWRSDSLPISLSSYSNPEGKIICDYQYTLKQAITDRVCRKPKLVLVDNEQLQYTGPDGSKSYSSIQALFKEQKISYSSILQDTDALVHILKLSASKLLSIRASNQDAGGLIVASSVAHARQIQTILNEQLKQPSVMVSYHDPDAQKIIEKFKNGHSPWIISIGMISEGTDIPRLQVCCHLSNVRTELYFRQVLGRILRVSDDDNQEAWLYTLAEENLVKFAEEIEQDIPESCLYIKQPENKEEEDAHSLETSSSHSVRTLAKPGDFKWNTSDTRVQIGNEDSIPHRSFTLGHFRERVIEAFIGI
>NZ_CP016352.1|WP_065298154.1|841225_842185_+|AAA-family-ATPase
MNSSAKELHQQVKNIFISNSQIDEILSDIEECREDSDGISEPECLIVVGDSGSGKTTIIDKYLADNPRVEVVDGSIIPILFTSLTANANPVTASERLLSAMGDPLAFSHGKDPAELMKIVKDLLKECRVELIIIDEFQHMIDRKSKGVLHNTADWLKMLIIDSKIPVILFGMPYSTEILRANNQLLGRFESQHHLEPFRVRSDLARYKIFLQLLDKALPFPKLSSLDSKDMMKRIYVFSKGNMRLIRRLINKAAKFALIENAQCITIDHFSRAAPKVSREACVDVNPFVAELKTLKIVEPSEDVGWENYLATQEEENSK
>NZ_CP016352.1|WP_065298153.1|839351_841229_+|DDE-type-integrase/transposase/recombinase
MSESNSDSHGFGGFFPSNNDNSSIPKESKGLPFGKDLEEQYTDIFAFDEYRRDEAIHRYNMLDALVELHGPNLTLKKINQSSDYLEDKFKPDVPSASSIYRYWNTFKESGFELAALIPGVTKGNRTQRVPIELEPYIKDAIESYYSEVSPTIDQAYTSLEVAIDRHNECHDAQLRPLSLEAFRKRIVKKPDYEKLLIKKGKSAADAYYRKVGQKPETTRVLEIVEADHTRLDLFVIDEARSIPLGRPWLTLLFDKHTKSVVGFYLGFEPPSYLSVALALENAILPKEYVQDLYPEVKNVWPCYGLPEHLIVDNGAEFNSKDFITACKTLHVKVKKNPVKKPWLKGSVERYFRTINNKLLSGIPGKSFSNIFARGDYEPQKNAIITRDNLMKIVHVWLIDIYQASPNGLENNIPNLAWAEAIRSAVPPRPYKGTRNELKFNLGKNDEVSLDRNGIRFKKTLRYSSKSLALYFGKHSYKQKSIKVKIKYDPICMGKIYVLDEDKHEFFAVESVNPDYAYSVSEWLHKVCCKYAREHIRKNYNHNDTVKAWRIIFDTIDEALHQSNGEKPKKIGIREASKSERTLEHATRTKSQHRPELQMPSDDEIDWDIEVNTDGWKIDSVRGTIK
>NZ_CP016352.1|WP_065298152.1|838707_839355_+|endonuclease
MWIFVMDNVKKRNLKNSKVKNISRFVSLKTDSVQVTESDLEFDACFHFEFAPQIKSFETQPLGFKYRLNGRLRRYTPDVLCNFFDGYAPYYEIKPKHIAEQEEFKEKFEAQKDYALAGGHDLLLLTEDDIQIYPLLENLKIIHRYACADGLDDIQFGLLKLFQKYGQLRISQVLVNSRGNSTTILPALYDLIAQKFLQLDWHRPIDQDTIVWSAQ
>NZ_CP016352.1|WP_014234860.1|838096_838582_-|acyl-CoA-thioesterase
MSSGQRDITLRFLAEPGDVNFGGKVHGGAVMKWIDLAAYACSAAWSGKYCITAYAGGIRFVAPIHVGNLVEVSAKVIYTGRTSMHIAIDVQASDPKEMKNRLTTHCIVIMVAVDEDGKPTDIPKWVPESDEDKALERSAIALMNMRKEIGEEMEAHVKYLK
>NZ_CP016352.1|WP_031779247.1|837691_837937_-|hypothetical-protein
MGTVKTTLSEETLTNLKAVEYQWVRTMYVEGYNETEINHYIQTCFGGDVTFANLFRRVALQQESLYTLLQYVGCAPSSREF
>NZ_CP016352.1|WP_014234862.1|836364_837255_+|maltose-ABC-transporter-permease-MalG
MAMVQGKSLKYRVWATHIAMWAFLALIIFPLLMIIAISFREGNFATGSLIPDNPTLDHWKLALGFSVTNADGTVTPPPFPVMTWLWNSVKVGGISAVLIVALSTTSAYAFARMKFKGKNTILKAMMIFQMFPAVLALVALYALFDKLGQYIPFLGLNTHGGLIFAYLGGIALHVWTIKGYFESIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIMVIGEVPVASLLLSDVNSYTLAVGMQQYLYPQNYLWGDFAAAAVLSAVPITAVFLLAQRWLVGGLTAGGVKG
>NZ_CP016352.1|WP_014234863.1|834777_836352_+|maltose-ABC-transporter-permease-MalF
MQSVQGTKAMTAPAANLPSSKKVFIKWALLGTVGILNGYATILMYSRGEIAFALLTIILTALALYIFGSKKTYAHRYIYPGIAGMILFILFPLAYTVGLAFTNYSAKNQLSFERAQTVLLDRTYQSGDSYPFTLYKTEQGHQIVIDKDGELLATPTFQLQGFSATDLDLAPIQEVTGEKEQIKTIVSNRDALSSVDLHLPSGDDIRMSGLRKFAAVVPLYTLQEDGEALFNNRTQETLLPNMETGYYQPIDENGQFVGSTVSPGFVVGIGSHNFERVWKDDGIKEPFISIFIWTIVFSALTVLFTLIIGLVLASVVQWEELKGRSVYRLLLILPYAVPAFISILIFKGLFNQSFGEINMLLEGLFGISPAWFSDPFMAKSMILIVNTWLGFPYMMILCMGLLKAIPDDLYEASAIDGANFVSNFTRITLPMMLKPLTPLLIASFAFNFNNFVLIQLLTGGGPNMIGTSEPAGYTDLLVSYTYRIAFEGAGGQDFGLASAVATLIFLLVGALALLNLRVTKVAQD
>NZ_CP016352.1|WP_065298157.1|844990_845587_-|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4
MDWYYRTITFLPEYRNNEVIAAKCLKELHRFNYKYHTRSIGVSFPLWAEETVGHKITFVSTNKMELDFLLSRRYFTQMTKLGYFSISTAQIVPDNCSYALFRRKQSIDKATSAGQAREIKRLERRALERGEIFDPAYYSKSMTHAFHSYHSLKEDSSGGNGFRLNIQMEQLEDTLSTGRFSSYGLGNTDNSLQVVPLI
>NZ_CP016352.1|WP_065298158.1|845590_846634_-|type-I-F-CRISPR-associated-protein-Csy3
MRLPTQLSYERSIEPTHVTFHVIWPEGRKKPLAYSANKQLGMKEGFTSAYKDNGEIDEKVTEYSLALGNIHELDYCCVPHGAESIECEFSVSFVSSHQKPFICSDPKVKSTLIKLVKLYEQKIGWEELATRYFMNICNGRWLWKNKKLPYSFSISVKPWPWDNEEAIITFEDIRKNYGDANSFKAHQHWGALIKLITDAFSQPNGLCKFEVSATLRYAKSDPLFPSLAFKNSVKGEKSRIYQTTEVDGVRSPILGSYKTGAAIATIDDWYPNAEEPLRISHYGVHKQDVYSYRFPNTGKDIFTLLERADEYVDQLEAADELSQETINDLHFIIANLIKGSPLQRKGS
>NZ_CP016352.1|WP_065298159.1|846605_848549_-|CRISPR-associated-protein-Csy2
MTKLAEIIENDTDDLNRDLRRAFRPLSRPIDITNTPLEAITILVNLTDKVLKQKDLLDRKTCKEKLRDEKWWASCLSTVKYRQSHNPKFPDIRASGIIRALPIGHLPPFLLSSSKLPTDNWAYANDSSQVNKSCFLTSEFIWDGHIHCLGQLLADIEHPLWNILRKLGCYVKTAKYISKELALVPPLEINTSLVRNYLAQISLPDNNNSYISLSPVASQSMQNDCYEVLREHYRFSAITRYSRATNMGSLAMSCGGNFRMIQFLPPIAKYKHHHLTDTQQWLTKPSLKAMREYIESSQWVMSPTEHATRKKSVIEDIKTMISKWLSSITAGQGNLNKRKLTERFNADLAKTKFASRYAYDPNLTQLVYTSIGSIIQSSYSQQLSELENSNENYLLLTNLRISGASAMNSPMSIGLPSMMAFYGFVHAFERNLQTVIPNFKIDSFSVCIHRIHVENRGLTREWALNTKNDITAPATRDDWQCDFTLSLILQCNNYSQITPREFMCLLPRRLARGNVTVAISDIERLGRSMSLDDAIKTIPFETGRWLSLNNEVTLHSVQDLVTELQENRMQLVNCIGYHLLEIPCAKRGSLREYKHAFAETILGVIKLFAISENTNPDQYFWQYHYSKQGSILLPRSVYNETTDSVIL
>NZ_CP016352.1|WP_065298160.1|848549_849737_-|TniQ-family-protein
MLLQRPKPYPDESLESFFIRVANKNGYSDVHRFLVAVKRYLLDIDLTKFQTFPTDICHINPYSSNKHSSSRTHALHQLSQLTFNEPANLLGIALNRSQMKFSPSTTALIRGAEVIPRSLLRKDSVPCCPTCLQKKGYASYRWHFSGYEYCHEHSIKLVSHCACGASYDYRYAGLSGVCPECGEIVSSPQESNGSKMLTVASWLSGADVKPLPIVPLSFRWGFIHWWSKVSDSSQTSNFGEFTDFWEQWPGPFHELIERDIEFNFEYAVLSQAELRVKDILGRMLFSSIQLPDRNFRSNIILKELFQYLEMNLWNDNGKLANLRLNTLEACIVLNCSREQITSMVEQRILIPNFRLGNRDVLAVTDYAFYLGDIYCLWLSEFQTDEFNRSFYVSRW
>NZ_CP016352.1|WP_065298161.1|849972_850959_+|sensor-histidine-kinase
MKTIYFPTYFDRDTLTGFFDELEVNIDTEDVCLDCSTLKFSKPTAMLVAGSKIRNWVRSRHSRGIKTRKRGVDTYSSVHSYLKHIGFFDFVLMAEGKCVGEARGSSSYIPVTKITKPELGTDEGALERWYEDIQSKVRGLARVISGQPEIHQDNRMYNYALREIIRNVFEHSGCDECYVFGQRWLNGQVEIVVVDEGVGIGSTLRESLGEISDSEAIKKSIQPGVSRTSNLSGADNIFDNSGFGLYVLTEVARSFGWYVLGSNSAKIIGYGNTLEESALNFQGTYFGFRLTRSPADFTNLAKDIIKVGEEEAKIQGVDRKASAMSKLF
>NZ_CP016352.1|WP_065298162.1|851125_852082_+|sensor-domain-containing-diguanylate-cyclase
MEPPKIPDNEAERLHALRALKILDTTHEERFDRVTRMAKRMFGVPISLVSLIDKNRQWFKSAQGLEVTETPREISFCAHAINHDGLFIIPNAVDDKRFCDNPLVTDDPNIRFYAGYPLKLRQGVNIGTLCLIDRVPREMDEEDCLLLQDLGAMIEQEIKSVQMATLDELTMVSNRRGFLLLADHTLKVCKRKKLKSAVLVFDLNKFKPINDAFGHHEGDYVLKTFAKALLESFRESDVVARWGGDEFVVFLTDSNTSDLEHILPRLKDKIVKVNEQSNKPYRIEYSCGVSHYNYDSPLSLEERIEEADYEMYKEKRMR
>NZ_CP016352.1|WP_065298163.1|852757_854713_-|hypothetical-protein
MKKIRSVYGAAVLTLILTACGSDSDGDSNESEDTSTSSTEVSGNVSAPGGEVALLEHQTILDRVLNDVFPPAYAGITGLQPVAGALVELITIDDDGNQVGKVISTTYTSITGDYTITVPEGVSLAGNLVVRITGDTDTDLRSQVVQESVDISPMSEFVLRKFIQSGSALSDLTTESVIKLRGQVEDFNLASRNDMLSMLAALENEVGEFVDKEIASISSTTSSAVDISGNYRLMDMALGLHDGDFGTYALDMFYSSVALTGNADGNVELELTDNEGAWGYVHGNDASSYYESVYYTELEEDETVAATFDSTNILTIEGEFEEEIDGDWAWRSPPQTIKFQKVNDSNVAFSLSTYNEARYAAIDTNGDGENDALDPSDHRGSDVGRGLLLLAEQPTNMSASDLNGDFGRVYFGSRFNNNGSVEVEVETNVLTFSGASTVDVSSTTQQHISRYGGYSTEEFDAEPGLSIVTDGNGDIVSVVGEEADGFVNSDYNFLVFYNADGLHGSDMEIDSTLAVKLPSETPALTGNTYRLIFTNAAMLSNTAFELSHSGFSTTLEFSSETSATLNGSIATIDLPSFGASLETTKEPVNLMASASVASNGAATITVTDNDEMFTMTGYFNESASLGIFTTTSANTDSDPDGLGLAVLVEID
>NZ_CP016352.1|WP_065298165.1|856579_858061_-|GGDEF-domain-containing-protein
MKKNSRSSVKFVLHYFVFSSLWILFSDKAVELLPGNLRIYSLAQSLKGVLFITITSLLLWVLIKRNNRELERANDIDFVTGLHSPFVFFRYLEQKINDSNQSEHYVLCLVDIDNFKPVSDQLGFEKSSQFLKDIAQSIDSPTYFPIFSSRIHTDGFACLIRMHGENQIDMHLAGIQRQFNKHALHYGIDVTCSIGVALFPTDGTSVKQLMSSAKYALTHAKKTKNAIRYHDKKLAEQDRQRQEIITDLHNAIQDEQIQIVFQPKYALKDKRVTGVEVLSRWEHHQYGAISPALFIKLAEENNLCSDLTTLVMKKASKQLREARLLGHVIPSVSVNISATELNSIEDMYQIEAYLKQNIEFARYLCFEITETAMLKNIEQCANFVRKLKQYGVTFSIDDFGVGYTSFEIFNKLEVDEIKIDQSFIKNIADNYRSRSITLGIIDIAKRFGIQVVAEGIETPQQLRILKGLECGQGQGFYLSRPVPISKLSEEFLK
>NZ_CP016352.1|WP_065298166.1|858954_859812_+|OmpA-family-protein
MNTIKKIFLLTTAATLLACTSKGNQLVGEETFSSQRVSSESELTSEVVFYNAGLQDDNSEAMVIFSNGSVMAGLQPSQYVVLPVCKGSQLFQVTHSGLGGAVNLQVAADSVQYVKLIPNSSPSGIRYEQSSISSISDALKDSSSKSFLVPRHNLNCEVDKPTEFNLSSESFFEFGGAQLMDVVKSDDLKNVIDFIHTHEDKGLKVTVSGYTDYIGDRDFNQSLSEARAQTVADYIVSRGFDGPIHAFGFGPSEPVVTCSSALERNDLIRCLQPNRRVTVRIWQTN
>NZ_CP016352.1|WP_065298167.1|859995_868110_+|hypothetical-protein
MDNQYEIIARNGDQIVERYDITSDSGSSAITAQDNVLYEVVDPTTGFAPQQVMFKRVDDTLEIRFGDESASVPADVVIDGYFQLDPPPKFIGLAEDGQYYYFVPQTGLTEDFIESLDDEDITFQSLGYETVDNETVWWPMILGGVALAGLGALALGGGGGGGIDDDDDDDELPAGGDTQAPNVGVNDLETNDSTPGLNGTVNDASASIVVTIDGVDYAAVNNGDGTWSLLDNTVSELDEGEYVVRVTATDDAGNTGTTSGSLVIDLTAPDAPIINDGNGSELSGSAEPGSQIQIDVNGDGNVDYTTVTDENGTWSVAPEPELEHGTEIVVTATDNAGNESEPSTAIIDALAPNVQIDDLLTNDTTPPLSGTTDDPTATIIVSLGGEQYTATNNGDGTWTLADNILPELDDGTYTVSVEATDDAGNSSIVEGYLEIDTTAPDAPIINDSDGSELSGSAEPDSRIDVDIDGDGEADYTVVTDGDGNWSVAPDTPLPDGTEVTVTATDNAGNSSNPSKSTVEGIAANVSVHNLITNDPTPALSGLVDIPEATLVVTVNGVDYTVTNQGDGSWTLVDNTLPELVDGTYNVSVTATTPTGIVSLGSGTVVIDTTPPASPLIDASDGTEIMGTAEAGSEIQVDIDGDGTPDYTTVADENGDWSIIPDTPLADGTVITATATDDAGNVSDASSAEVDARAPVVSINDALTNDATPELTGLVDDPTASITVTVDGNDYNATNNGDGTWTLADDTLPPLTDNSYTVTVTATDAVGNQGTATGTLVIDTVAPDAPVINAGNGEEISGTAEANSVVNIDVNGDDTPDYTTTADENGNWSVTPDSPLLDGTEIDATATDQVGNTSEPASSTTNAAASPVTVTSDLTNDPTPPLSGTIDDPSATVVVNVNGIDYPAVNNGDGTWTISDDTLSSLVDGSYSVVVTATTDLGAISTANGTLTIDATAPAVTVDDVASNDTTPALNGTVDDNTASVTVNVNGMDYPATNNGDGTWTLADDTLPALTDNSYTVTVTATDAAGNQGTATGTLAIDTGAPNDGDGLNSITFNDGGDELLNADEATSVSLSGTVETGATVNALTISDGTTTIPVDAANISVVGGVVTVSGLDLSGLNDGLLTVTMEVTDEAGNTGTVTDTTTLDTTSPVVSVDDVLTNDATPALTGTVDDNTASVTVNVNGMDYPATNNGDGTWTLADDTLPALTDNSYTVTVTATDAAGNQGTATGTLAIDTGAPNDGDGLNSITFNDGGDELLNADEATSVSLSGTVETGATVNALTISDGTTTIPVDAANISVVGGVVTVSDLDLSGLNDGLLTVTMEVTDEAGNTGTVTDTTTLDTTSPVVSVDDFLTNDATPALTGTVDDNTANVIVNVNGTDYPATNNGDGTWTLADDTLPVLTDNSYTVTVTATDAAGNQGTATGTLAIDTGAPNDGDGLNSITFNDGGDELLNADEATSVSLSGSVETGATVNSLTISDGTTTIPVDAANISVVGGVVTVSALDLSGLNDGLLTVTMEVTDEAGNTGTVTDTTTLDTSIEGVTGEPIVSFDSISVDSGTDGDFITSDTTLILTGSVNTTETTTLTVDVSGTEYTQGVSPELSLDGSGNWTLDLSGSALSAGTYIVVATVTDAAGNSESSPAQNVIIQALDAVNDENSLDMGEPSVTVAPAQTTQDVQVIGVAESTGGADASAAFSVSAEHVGEVTVEVSQKSLVAVADAYKVEIYNASNELVYSSVSADSQLADVAGLDIFNVTGDETITFTVDGLPAGDYTVVVRNDESQLEDLLDSDGSNDVNLTELGDAGVVLGPDNQDSVLNTVEGTLGVVLGPVVRGILETALDTTTEIGAGELVNVLTAGLDGLGLTGSLDIVLSAVADALLSNTLTVLQDTDITTTVTEYSYDGVTEAQGNLISGDGSGVGEDSIIVGSTITAIENFLGQSVVVSASGITSIEGEFGTLEIESDGSYRYVANGDRASVGQNEVFTYTLSDGETSDTATLTIAISGSDLPAVVAQSDSIDMALGVQTSQVSEPVTDSDMQVLGLLETASSESVSTASVTTASISSTPIVVSEDFNGEVVVEVSQEALVAVADAYVVEIVDAQGQVVGQAVSPENPLVGDVAGLTVLGLTGDDTLVANFSGLPAGEYTVVVRNDESELANLFDTSGDSNISLTELGAGGVVLGAENQDVLLDAIESALNGSVLGSAGGLGVGSAVRTFILEPLLATVDSIGAGDLVDTLTTGLNAIGLTSVVDEVLDIVADTLLSNTLTLLQQTDVTSTLTEYQFEGSTTVSGNVIQGGSAGEVADTLASGGVVTQVTNSDGDLVTVLGSGTAGVTLTGEYGELTVYEDGSYTYVANGARAGLGDSDSFTYTISDGFSSSSADLTFNLTGQGAASDTAIAELHYDYVSVVEPEVTDALNVSWLVSLGGTQSDTYNIEVVANTTQDLLFTLDSNELLGLGSNLTLTLSQDVDGTMTEVESFSDDALLSLLSGNSGQVIFEGLTEGSYEVTLTVNVPVGVAGSLGADLTSTVHSLDQYAVDEVSIAEGNLFDNDVQFGTDYTLSVSEDGVDFQTVTTSTTLVGQYGTLNVDQAGNYSYTPDSDLAVFGGTLNDTFIYQVAYPDGTVEQTELDVFVKATGEGVPESVTTMMQAMLAYTSEDDVSLLFTDESDDQTVQLASTDPVDSLVIDGVVFSDTGTSTQSLLIEDESNVVY

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP016352_1	1.1\|844681\|31\|NZ_CP016352\|CRT	844681-844711	31	NZ_CP009619	Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence	129180-129210	3	0.903
NZ_CP016352_1	1.4\|844743\|28\|NZ_CP016352\|PILER-CR	844743-844770	28	NZ_CP046163	Vibrio sp. THAF191c plasmid pTHAF191c_b, complete sequence	388775-388802	3	0.893
NZ_CP016352_1	1.4\|844743\|28\|NZ_CP016352\|PILER-CR	844743-844770	28	NZ_CP046066	Vibrio sp. THAF191d plasmid pTHAF191d_b, complete sequence	573065-573092	3	0.893
NZ_CP016352_1	1.4\|844743\|28\|NZ_CP016352\|PILER-CR	844743-844770	28	NZ_CP045356	Vibrio sp. THAF64 plasmid pTHAF64_a, complete sequence	1187747-1187774	3	0.893
NZ_CP016352_1	1.1\|844681\|31\|NZ_CP016352\|CRT	844681-844711	31	NZ_CP034238	Aliivibrio salmonicida strain VS224 plasmid pRVS1-224, complete sequence	134739-134769	9	0.71

1. spacer 1.1|844681|31|NZ_CP016352|CRT matches to NZ_CP009619 (Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence) position: , mismatch: 3, identity: 0.903

tcgtggttgctcttgaagaagattatgaaca	CRISPR spacer
ttgttgtagctcttgaagaagattatgaaca	Protospacer
*.** ** ***********************

2. spacer 1.4|844743|28|NZ_CP016352|PILER-CR matches to NZ_CP046163 (Vibrio sp. THAF191c plasmid pTHAF191c_b, complete sequence) position: , mismatch: 3, identity: 0.893

actctacggtttcttgctcttgcctcat-	CRISPR spacer
accctacggtttcttgctctt-ccgcatg	Protospacer
**.****************** ** ***

3. spacer 1.4|844743|28|NZ_CP016352|PILER-CR matches to NZ_CP046066 (Vibrio sp. THAF191d plasmid pTHAF191d_b, complete sequence) position: , mismatch: 3, identity: 0.893

actctacggtttcttgctcttgcctcat-	CRISPR spacer
accctacggtttcttgctctt-ccgcatg	Protospacer
**.****************** ** ***

4. spacer 1.4|844743|28|NZ_CP016352|PILER-CR matches to NZ_CP045356 (Vibrio sp. THAF64 plasmid pTHAF64_a, complete sequence) position: , mismatch: 3, identity: 0.893

actctacggtttcttgctcttgcctcat-	CRISPR spacer
accctacggtttcttgctctt-ccgcatg	Protospacer
**.****************** ** ***

5. spacer 1.1|844681|31|NZ_CP016352|CRT matches to NZ_CP034238 (Aliivibrio salmonicida strain VS224 plasmid pRVS1-224, complete sequence) position: , mismatch: 9, identity: 0.71

tcgtggttgctcttgaagaagattatgaaca	CRISPR spacer
agagaattgctcttgaagaagattccgaacg	Protospacer
  . ..****************** .****.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2009500 : 2017030

Escherichia_phage(66.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014233919.1\|2009500_2010148_-	aldolase	A0A077SK32	Escherichia_phage	9.0e-69	62.4
WP_065298835.1\|2010159_2011416_-	four-carbon acid sugar kinase family protein	A0A077SLJ7	Escherichia_phage	2.1e-130	57.2
WP_014233917.1\|2011440_2012340_-	NAD(P)-dependent oxidoreductase	A0A077SLF7	Escherichia_phage	3.1e-99	67.0
WP_014233916.1\|2012620_2013394_+	DeoR/GlpR transcriptional regulator	A0A077SK06	Escherichia_phage	1.7e-53	46.8
WP_065298836.1\|2013402_2014242_-	aldo/keto reductase	A0A1V0SDE7	Indivirus	2.2e-11	24.8
WP_081280834.1\|2014664_2016050_+	guanine deaminase	NA	NA	NA	NA
WP_065298837.1\|2016085_2017030_-	carbon-nitrogen hydrolase family protein	M1I5Z5	Acanthocystis_turfacea_Chlorella_virus	2.9e-07	27.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP016351

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP016351_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016351_1

2931641-2931897

Orphan

Consensus_repeat	Method
GTGCCTCCTTAGCTCAGTAGGTAGAGCAACGGACTGATAATCCG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP016351_1

>merge|NZ_CP016351|1|2931641-2931897|PILER-CR
GTGCCGACTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAGTAGGTCACCAGTTCGATTCCGGTAGTCGGCACCATTCTTTTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCTCGTGTCGGTGGTTCGATTCCGCCTCGAGGCACCATTATTTGGTGCACTTGCTTAATTTAATTGATTAGCAAGACACAAACAGAATAGTTCCTCCTTAGCTCAGTTGGTAGAGCGACGGACTGTTAATCCG

>NZ_CP016351|1|1|2931641-2931897|PILER-CR
GTGCCGACTTAGCTCAGTAGGTAGAGCAACTGACTTGTAATCAG	TAGGTCACCAGTTCGATTCCGGTAGTCGGCACCATTCTT
TTGCCTCGATAGCTCAGTCGGTAGAGCAGAGGATTGAAAATCCT	CGTGTCGGTGGTTCGATTCCGCCTCGAGGCACCATTATTTGGTGCACTTGCTTAATTTAATTGATTAGCAAGACACAAACAGAATA
GTTCCTCCTTAGCTCAGTTGGTAGAGCGACGGACTGTTAATCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016351.1\|WP_014233052.1\|2949247_2950318_-\|LPS-export-ABC-transporter-permease-LptG	unknown	unknown	gnl\|CDD\|237900
NZ_CP016351.1\|WP_065297398.1\|2926468_2927497_-\|DNA-methylase	unknown	unknown	gnl\|CDD\|223971
NZ_CP016351.1\|WP_065297402.1\|2941980_2943234_-\|HD-GYP-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NZ_CP016351.1\|WP_014233051.1\|2948736_2949216_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP016351.1\|WP_014233041.1\|2927508_2928228_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP016351.1\|WP_065297403.1\|2943535_2944210_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP016351.1\|WP_065297400.1\|2929892_2931035_+\|membrane-bound-lytic-murein-transglycosylase-MltC	unknown	unknown	gnl\|CDD\|183271
NZ_CP016351.1\|WP_065297399.1\|2928431_2929508_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|182805
NZ_CP016351.1\|WP_065297401.1\|2932194_2933820_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NZ_CP016351.1\|WP_065297404.1\|2946430_2947096_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187643
NZ_CP016351.1\|WP_020334475.1\|2950321_2951422_-\|LPS-export-ABC-transporter-permease-LptF	unknown	unknown	gnl\|CDD\|185075
NZ_CP016351.1\|WP_065297700.1\|2924203_2925379_+\|radical-SAM-family-heme-chaperone-HemW	unknown	unknown	gnl\|CDD\|235550
NZ_CP016351.1\|WP_065297397.1\|2923583_2924186_+\|XTP/dITP-diphosphatase	unknown	unknown	gnl\|CDD\|234648
NZ_CP016351.1\|WP_014233039.1\|2925459_2926380_-\|glutaminase-B	unknown	unknown	gnl\|CDD\|234880
NZ_CP016351.1\|WP_014233043.1\|2929527_2929800_+\|oxidative-damage-protection-protein	unknown	unknown	gnl\|CDD\|180059
NZ_CP016351.1\|WP_014233048.1\|2944348_2945287_-\|bile-acid:sodium-symporter-family-protein	unknown	unknown	gnl\|CDD\|223462
NZ_CP016351.1\|WP_014233036.1\|2922653_2922944_+\|YggU-family-protein	unknown	unknown	gnl\|CDD\|179931
NZ_CP016351.1\|WP_020334002.1\|2923018_2923450_+\|DUF4426-domain-containing-protein	unknown	unknown	gnl\|CDD\|379616
NZ_CP016351.1\|WP_020334476.1\|2951622_2953131_+\|leucyl-aminopeptidase	unknown	unknown	gnl\|CDD\|234863
NZ_CP016351.1\|WP_065297405.1\|2947274_2948543_+\|DUF2254-domain-containing-protein	unknown	unknown	gnl\|CDD\|378351

Protein	Function_ID	Function_description	E-value
NZ_CP016351.1\|WP_014233052.1\|2949247_2950318_-\|LPS-export-ABC-transporter-permease-LptG	gnl\|CDD\|237900	PRK15071, PRK15071, lipopolysaccharide ABC transporter permease; Provisional.	0
NZ_CP016351.1\|WP_065297398.1\|2926468_2927497_-\|DNA-methylase	gnl\|CDD\|223971	COG1041, COG1041, Predicted DNA modification methylase [DNA replication, recombination, and repair].	1.53161e-08
NZ_CP016351.1\|WP_065297402.1\|2941980_2943234_-\|HD-GYP-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	2.52274e-68
NZ_CP016351.1\|WP_014233051.1\|2948736_2949216_+\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	1.51369e-15
NZ_CP016351.1\|WP_014233041.1\|2927508_2928228_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	4.68784e-109
NZ_CP016351.1\|WP_065297403.1\|2943535_2944210_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.3495e-60
NZ_CP016351.1\|WP_065297400.1\|2929892_2931035_+\|membrane-bound-lytic-murein-transglycosylase-MltC	gnl\|CDD\|183271	PRK11671, mltC, membrane-bound lytic murein transglycosylase MltC.	6.93881e-147
NZ_CP016351.1\|WP_065297399.1\|2928431_2929508_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|182805	PRK10880, PRK10880, adenine DNA glycosylase.	0
NZ_CP016351.1\|WP_065297401.1\|2932194_2933820_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.5969e-58
NZ_CP016351.1\|WP_065297404.1\|2946430_2947096_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187643	cd08939, KDSR-like_SDR_c, 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR. These proteins include members identified as KDSR, ribitol type dehydrogenase, and others. The group shows strong conservation of the active site tetrad and glycine rich NAD-binding motif of the classical SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.10544e-69
NZ_CP016351.1\|WP_020334475.1\|2950321_2951422_-\|LPS-export-ABC-transporter-permease-LptF	gnl\|CDD\|185075	PRK15120, PRK15120, lipopolysaccharide ABC transporter permease LptF; Provisional.	2.71332e-132
NZ_CP016351.1\|WP_065297700.1\|2924203_2925379_+\|radical-SAM-family-heme-chaperone-HemW	gnl\|CDD\|235550	PRK05660, PRK05660, radical SAM family heme chaperone HemW.	0
NZ_CP016351.1\|WP_065297397.1\|2923583_2924186_+\|XTP/dITP-diphosphatase	gnl\|CDD\|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	1.09854e-124
NZ_CP016351.1\|WP_014233039.1\|2925459_2926380_-\|glutaminase-B	gnl\|CDD\|234880	PRK00971, PRK00971, glutaminase; Provisional.	0
NZ_CP016351.1\|WP_014233043.1\|2929527_2929800_+\|oxidative-damage-protection-protein	gnl\|CDD\|180059	PRK05408, PRK05408, oxidative damage protection protein; Provisional.	3.33891e-59
NZ_CP016351.1\|WP_014233048.1\|2944348_2945287_-\|bile-acid:sodium-symporter-family-protein	gnl\|CDD\|223462	COG0385, COG0385, Predicted Na+-dependent transporter [General function prediction only].	2.19836e-83
NZ_CP016351.1\|WP_014233036.1\|2922653_2922944_+\|YggU-family-protein	gnl\|CDD\|179931	PRK05090, PRK05090, hypothetical protein; Validated.	6.66239e-61
NZ_CP016351.1\|WP_020334002.1\|2923018_2923450_+\|DUF4426-domain-containing-protein	gnl\|CDD\|379616	pfam14467, DUF4426, Domain of unknown function (DUF4426). Members of this entry are found mostly in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine biosynthesis protein MetW. On the other hand, in most Vibrio species it appears as a part of a conserved operon involved in possible response to stress.	3.41423e-65
NZ_CP016351.1\|WP_020334476.1\|2951622_2953131_+\|leucyl-aminopeptidase	gnl\|CDD\|234863	PRK00913, PRK00913, multifunctional aminopeptidase A; Provisional.	0
NZ_CP016351.1\|WP_065297405.1\|2947274_2948543_+\|DUF2254-domain-containing-protein	gnl\|CDD\|378351	pfam10011, DUF2254, Predicted membrane protein (DUF2254). Members of this family of bacterial proteins comprises various hypothetical and putative membrane proteins. Their exact function, has not, as yet, been defined.	4.96782e-119

>NZ_CP016351.1|WP_065297400.1|2929892_2931035_+|membrane-bound-lytic-murein-transglycosylase-MltC
MKKIVFIVAALLLTAGCSREVVEKFYDVEYEPTNRFANNLAELPGQFEKDTAALDSLINSFSGNIQKKWGKREVKLAGKSNYVKYIDNYLSRAEVDFQKGVITIETVSPTEPQKHLKNAIITTLLTPDDPAHVDLFSSKDIKLEGQPFLYKQVVDQDNKPIQWSWRANRFADYLISHEIKTKDVDFKKAYYVEIPMVEDHFIQRSYQYANIVRQAAEKYDIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFALVKNRSGQPSPEYLFNPENNIDTGTAYFYILKNRYLKDVSHPTSLEYSMISAYNGGTGGVLNTFNRSDRKRAMRDLNSLQPNQVYWALTKKHPNAEARRYLEKVTNFKKEFNSVQTF
>NZ_CP016351.1|WP_014233043.1|2929527_2929800_+|oxidative-damage-protection-protein
MSRTVFCARLKKEGEGLDFQLYPGELGKRIFDNISKEAWAEWQHKQTMLINEKKLNMMDPEHRKLIETEMVNFLFEGKDVHIDGYTPPSE
>NZ_CP016351.1|WP_065297399.1|2928431_2929508_+|A/G-specific-adenine-glycosylase
MTPFASAILEWYDAYGRKDLPWQQNKTAYSVWLSEIMLQQTQVTTVIPYYQRFLERFPTVVDLANAEQDEVLHLWTGLGYYARARNLHKAAKEVAQTYNGEFPLDIEQMNALPGIGRSTAAAVLSSVHKQPHAILDGNVKRTLSRCFAVDGWPGQKKVENKLWEIAEAHTPQTDVDKYNQAMMDMGAMVCTRSKPKCTLCPVADLCVAKKQGNILDYPGKKPKKDKPVKQTRFVMLHHKNANGHEVWLEQRPQTGIWGGLFCFPQTEHVDVESDIDLLLEQRGIQANDIKEQQTLITFRHTFSHYHLDITPILIDLSKQPDVIMEGNKGLWYNLSKPEEVGLAAPVKLLLETLPHELR
>NZ_CP016351.1|WP_014233041.1|2927508_2928228_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MSEVTTNEYNEDGKLIRKIRSFVRREGRLTKGQESAMNECWPTMGIDYKAELLDWKEVFGNDNPVVLEIGFGMGASLVEMAKNAPEKNFIGIEVHSPGVGACLADAREAGLTNLRVMCHDAVEVFEHMIPNDSLATLQLFFPDPWHKKRHHKRRIVQLEFAEMVRQKLIPNEGIFHMATDWENYAEHMIEIMNQAPGFENIAEEGDFVPRPEERPLTKFEARGHRLGHGVWDIKFKRTA
>NZ_CP016351.1|WP_065297398.1|2926468_2927497_-|DNA-methylase
MYHYAILANPGHNRIYFDSAMTIACSELKAMLAAEGVEVTEIGSKDVGLPAALVFSCAEALNEAQTRKIAASSIYYALFEVREDGLLRPIQAPAFNTFPESMSQILRYTGKTNEQFTRLMVNLGVSAANTDSAQLTLMDPMCGKGTTLFEGLIHGLNVVGVEINQKWVQEIQTFVVKFMKNGRFKHKVSKEKRTSGGKKVADGFVVEAAATKEDYNQGNLQTMKLYSADTRIADQVVKKNSVDVMVSDLPYGVQHGSKNAKDSKLNRSPLELLKEALPAWKVVLKKQGSVVLSFNEFTLKWKDVAALFEEQGWKVLSEDPYIGYLHRVDQSINRNIIVAVKP
>NZ_CP016351.1|WP_014233039.1|2925459_2926380_-|glutaminase-B
MKPTVEILTDILTEVRPLIGQGKVADYIPALAKVPSNKLGIAVYTNDGEVIKAGDADEPFSIQSISKALSLTLAMCLYKQEEIWARVGKEPSGQAFNSLIQLEMEQGIPRNPFINAGAIVVADLLQSRLSAPRQRLLEFVRQLSGDTHIVYDKVVAASEMMHGDRNAAIAYLMRSFGNFENEVIPVLQNYFHACALKMSCVDLAKTFSYLANKGTSVHTGKPIVSPTQTKQLNALLATCGLYDGAGEFAYRVGMPGKSGVGGGIIAVVPGDMTIAVWSPELDPAGNSLAGTKALELLSERIGRSIF
>NZ_CP016351.1|WP_065297700.1|2924203_2925379_+|radical-SAM-family-heme-chaperone-HemW
MLTPPALSLYVHIPWCVQKCPYCDFNSHELKAEIPEEQYINALLEDLDTDIEKYHLNDAPRPLHSIFIGGGTPSLISAQGIERLLKGIEERIPFKTDIEITMEANPGTIEAERFAGYRKAGVTRISIGVQSFEQEKLERLGRIHGKDEAVNAANLAHQIGLNSFNLDLMHGLPDQSIEQALADLDKAIELAPPHLSWYQLTIEPNTMFYYKPPTLPDDDDLWDIFELGHKKLAAAGYVQYEISGYSKPGFQCQHNLNYWRFGDYLGIGCGSHGKLSFADGRIIRTTKVKHPRGYLAAYQNMVKPYLHTEQFVEDEDRPFEFFMNRFRLMEACPKQDFIDTTGLPLSSIQDTINWALELGYLSETETHWQITEKGKLFLNDLLEAFMAEEDE
>NZ_CP016351.1|WP_065297397.1|2923583_2924186_+|XTP/dITP-diphosphatase
MKKIVLATGNQGKVREMADLLSDFGFEVLAQSEFNVSEVAETGTTFIENAIIKARHAAQETGLPAIADDSGLEVDYLNGAPGIYSARYAGEGATDQENLEKLLKAMEGVPEADRTARFHCVLVLMRHKDDPTPVVCHGKWEGRILTEAHGENGFGYDPVFFVPEDDCASAELEPARKKQLSHRGKALKSLFAQLSEQAAQ
>NZ_CP016351.1|WP_020334002.1|2923018_2923450_+|DUF4426-domain-containing-protein
MNKWITALLISLLSFPTFAEQFKNMKDIEVHYVAFNSTFLTPKIARSYDIKRNGYLAIINISVLDRASLGKPALEAQVAGQAKNLIGQTQQLTFREVKEGDAIYYLAELPVTHEETFTFDIDVKSGNKGSGKLQFTQKFYVEE
>NZ_CP016351.1|WP_014233036.1|2922653_2922944_+|YggU-family-protein
MSAAVWRDGEDIVLRLYIQPKASRDKIVGLHGEELKIAITAPPVDGKANAHLTKFLAKQFKVAKGLVHIEKGELGRHKQIRIESPTQIPTDIEAIL
>NZ_CP016351.1|WP_065297401.1|2932194_2933820_+|methyl-accepting-chemotaxis-protein
MKLKTQAYLLSAIILLALLALTATGLWTLRVASNLDNKARVTELFKSAYSILTEVEAMAASGELPEDEAKALATRLLRNNIYKDNEYVYVADENMIFVAAPLDPQLHGTSFHDFKDSNNNSVGQLILDILDNKTGQIVEYTWSQTQTDGSIEEKHSIAEKTPHWGWVVGTGIGFNEVNARFWATAQWQLILCLFIAGTILTSLIIAIRKMLNVLGGEPHDVRQAVQAVSQGNIQTSFDTVAPKDSIYDAVQNMSQSLAIMVTNLDSSMLALRSELSAVESRSGTIADLTLSQQESTAMIATAMTEMASSANQVATSANDTARNTDEADKQSQQTQSLICSTVDNIQGLANQLNTASLAVANLDQDVNNIVKVLDVIGDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAGRTQDSTKEIQNMISNLQQGSRHAIQTMEICAETSQSTVTQSQSASEALQQIVTALEAITTMSQQIATAAAEQTHVSDDIAHRINLIEESGYQLNSVVTESQSSTQSLASLANDLEGWVNKFSVKH
>NZ_CP016351.1|WP_065297402.1|2941980_2943234_-|HD-GYP-domain-containing-protein
MAAIKLTVDRIQPGLHIRLPLKWNDHPFLLNSFKIKDQGQVEMIRHLGVKFVYFNPEQSDSLPLPVNQDREDKVKSDDSLDLETQALWQEKQKRIEKLSAYRRRVIQCEKEFERSLARMRSVMMKIRNRPVAAVNEAKLLTEDIVDKLMCDDNVTLHLMNGKNEYEDIYFHSLNVAVIAMMIGRAKGYSANQLKELSFAALFHDMGKVKIPTAILRKQEPLTVPEENYLKLHTKYGLDLANQIEDFPETAKTVIEQHHELRDGSGYPKGLQGDEINEFAQIIIVANAFDNLCHTRITSEQKIPYTALSHLYKNCKHLYKEENLKLLIKFMGVFPPGTVVQLTNNMIGLVISVNASNLLFPNVLVYDPSVPRTQAPILDLASKDLRIVNAIHPSKLPENIKEYLNPRSRISYFFDTDT
>NZ_CP016351.1|WP_065297403.1|2943535_2944210_+|SDR-family-oxidoreductase
MKILVTGASSGIGFELVKQLCADHHDVFATGRNKNKLTELHQLTGCKFASYDLTESQQVMDMFKQATEELGGLDVLINNAGMNTRKCAIDEFSLEEFEQQYAINLRAPAILCREALSLMKEQKSGYIINVTSTVAKRASETMAVYTTMKQGLAGFTGVLMKEAQPHGIKVTNLYPGGTDTNFRAASRPEYMQPESVARTILGLLKLPEDVVVHEMVFRPLVELE
>NZ_CP016351.1|WP_014233048.1|2944348_2945287_-|bile-acid:sodium-symporter-family-protein
MIGRLTQLFPVWAVIFALTAYFSPSLFVDLKSQIVPLLTIIMLAMGISLSPSDFLNVLKHKKAVGVGVFLQFLIMPLAALLISFLLGFSTELTVGMVLVGSVAGGTSSNVMVFLAKGDVALSISMTAISTLLGVILTPLLVEGLIGQSVDVPVSGMLMSLVKIVLLPVSIGVIINTFIPKAVAKVNAILPLISMLAIVVIIAIVVALNAENLNTIGPLVALAVILHNGLGLTAGYYCCRLLGFNESTCRTIAFEVGLQNSGLATALAMKFFSPASAIAGTIFSVWHNISGSLLAGYWASKKARKAKAVTNSL
>NZ_CP016351.1|WP_065297404.1|2946430_2947096_-|SDR-family-NAD(P)-dependent-oxidoreductase
MILITGASSGLGAELAKLYDSDGQPTYLTGRSEGKLSEITDSLSNNIGYQACDLSLHQDVELLFEQLDQPPQTVIHSAGSGYFGLLEDQEPEQIQKLINNNLNSAINVLRELVKRYKDHSVNVVMIMSTASQQPKAQESTYCAVKWAVKGLIESVRLELKGKPMKIIAVYPGGMATEFWETSGKSLDLSSFMQAEDAAQMIHDAVSSIGNGYVSDITVNRL
>NZ_CP016351.1|WP_065297405.1|2947274_2948543_+|DUF2254-domain-containing-protein
MTGSKWQWLLKQVTRKLWVRTSLFALLAVATALMSIVLNEFVVLPPAINVSSDLLNNILNILATSMLAVTTFSLNIMVSAYTAASAGVTPRATKLLMEDSTTQNALATFLGSFLFSLVGIIALGVGAYHEQARIYLFIVTMVVIVMIILTLLRWIQHLSVLGRVSETTSKVEQALISAIRKRGNEPWLGARPWSHPEHKPRGSKPIYSQEIGYLQHIDMHHLDGIAEENQCTIYIERQPGNFVYSGQPIAWLCGELEEESEVSAAFTIRTERSFDQDPRFGLVVLAEIASRALSPAVNDNGTAIDVLGRAIRALSLWGELLKQRPIKTRFPRLFVPSLSCQDLFDDVFLPIAHDGAAQLQVQIRLQKSLLAISSMHPKLFASPAQKLSEKALELALSQHYTEDEKHQLSQLSHQVIDQKFHG
>NZ_CP016351.1|WP_014233051.1|2948736_2949216_+|RDD-family-protein
MTTSTTLPTAGLFRRLAALVYDSLIVIAIEMMAAGVVMAIVFALNAAGLLSYGEYVDAADMLSKHPVISPIFTLYLAVVWIYFFVFFWTRAGQTLGMRAWKLQVRNAADDAPITVTQALIRIATSGFGLANLTVPIDPQKRGFHDMWAKTKVVVLPKAQ
>NZ_CP016351.1|WP_014233052.1|2949247_2950318_-|LPS-export-ABC-transporter-permease-LptG
MFKILDLYIGRTIISTTALVLATFVGLSGIIKYVEQLRKVGRGVYDLMHALYFVLLSIPRDIEMFFPMAALLGALIGLGMLASSSELVVMQAAGFSKLDIGLSVLKTAVPLMLIVMTLGQWGAPEAQKMARDLRSFAISGGSIVSVRAGVWARDANDFIFIGKVEDDKLYALNMWRFDEDKNLQKVIFAEEVDYEQDNNWVMKDVQITDMQGETVISKQSVDQMEWQTSLAPDKLAVVTVKPEELSLSGLYDYVTYLKASEQDASRYELAFWRKLTQPLSIAVMMLMALSFVFGPLRSVTMGARVLSGVVAGFTFYISSEFFGPLTLVYGIPPVFGALAPSLVFLAIAVSLLRRKL
>NZ_CP016351.1|WP_020334475.1|2950321_2951422_-|LPS-export-ABC-transporter-permease-LptF
MIIVRYLIRETLKSQFAIFFVLFLVFLSQKFISVLADASDGDIPAGLIFSIVGLNMPAMGLLMLPLSLYIGILITFGRLYAESEIVVMNATGIGNKFLVQAALYLALITSAVAAFNALWLSPWSQERVEQLYEQVAAENSVDLLQKGQFQGTPDGSSVVFIDDIKDNTLSNVFVAQMRPRDSVLPSVMFSSSGEVKELSDGRQIITMKEGTRYEGVPTRVEYMITKFDQYEGVIGQREVKKKGRDWEAYPTADLIGHPDPEAQAELQWRISLFVCIPLLTMLVIPLSAVNPRQGRFAKMGPAILIYLAYFLAISATKSALEDGSIPTTVGMWPINAMLLIVAILANMMDSVPARRMKEKFRKKRLA
>NZ_CP016351.1|WP_020334476.1|2951622_2953131_+|leucyl-aminopeptidase
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPVAEQLDKISDGYISSLLRRGDLEGKPGQMLLLHQVPGVLSERVLLVGCGKERELGERQYKEIIQKTISTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVEATKDGLYTFNQFKSVKPETRRPLRKLVFNVPTRRELSLGEKAITHGLAIASGVKASKDLGNMPPNVANPAYLASQARRLADDYETVTTKIIGEQEMEKLGMTSYLAVGRGSKNESMMSIIEYKGNPDSDAKPIVLVGKGLTFDSGGISLKPGEGMDEMKYDMCGAASVFGTMKALAKLNLPINVIGVLAGCENMPGSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPDCVVDVATLTGACVIALGHHISGVLSNHNPLAHELVNASEQASDRAWRLPMADEYHEQLKSPFADMQNIGGRPAGTITAGCFLSKFAKKYNWAHLDIAGTAWKSGAAKGSTGRPVSMLVQFLLNRSGQETEE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	NZ_CP016351.1	2931308-2931346	0	1.0

1. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to position: 2931308-2931346, mismatch: 0, identity: 1.0

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccattctt	Protospacer
***************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	NZ_CP041417	Escherichia coli strain STEC711 plasmid pSTEC711_1, complete sequence	296499-296537	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	NZ_LN868946	Salmonella enterica subsp. enterica serovar Senftenberg strain NCTC10384 plasmid 4, complete sequence	103821-103859	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	KU052038	Escherichia phage SerU-LTIIb, partial genome	1164-1202	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	KU052038	Escherichia phage SerU-LTIIb, partial genome	3070-3108	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	LN997803	Escherichia coli phage phi467	15124-15162	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	NZ_CP023526	Cedecea neteri strain FDAARGOS_392 plasmid unnamed, complete sequence	1927-1965	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	NZ_CP022660	Salmonella enterica subsp. enterica strain RM11060 plasmid pRM11060-2, complete sequence	52076-52114	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	NZ_CP045061	Salmonella enterica subsp. enterica serovar Muenchen strain LG26 plasmid pLG26p2, complete sequence	52082-52120	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	NZ_CP045054	Salmonella enterica subsp. enterica serovar Muenchen strain LG24 plasmid pLG24p2, complete sequence	52087-52125	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	NZ_CP045058	Salmonella enterica subsp. enterica serovar Muenchen strain LG25 plasmid pLG25p2, complete sequence	52086-52124	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	NC_021742	Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence	35426-35464	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	MH791411	UNVERIFIED: Escherichia phage Ecwhy_1, complete genome	13643-13681	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	MH494197	Escherichia phage CMSTMSU, complete genome	196770-196808	4	0.897
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	NZ_CP054057	Scandinavium goeteborgense strain CCUG 66741 plasmid pSg66741_1, complete sequence	85815-85853	5	0.872
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	KY653118	Morganella phage IME1369_01, complete genome	696-734	5	0.872
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	LC494302	Escherichia phage SP27 DNA, complete genome	76611-76649	7	0.821
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	LT603033	Escherichia phage vB_Eco_slurp01 genome assembly, chromosome: I	17117-17155	7	0.821
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	NC_027364	Escherichia phage PBECO 4, complete genome	207830-207868	7	0.821
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	NC_049942	Escherichia phage JLK-2012, complete sequence	23524-23562	7	0.821
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	MK817115	Escherichia phage vB_EcoM_phAPEC6, complete genome	52943-52981	8	0.795
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	MH383160	Escherichia phage UB, complete genome	272122-272160	8	0.795
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	MK327931	Escherichia phage vB_EcoM_G17, complete genome	77927-77965	8	0.795
NZ_CP016351_1	1.1\|2931685\|39\|NZ_CP016351\|PILER-CR	2931685-2931723	39	KM507819	Escherichia phage 121Q, complete genome	77938-77976	9	0.769

1. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to NZ_CP041417 (Escherichia coli strain STEC711 plasmid pSTEC711_1, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatatgc	Protospacer
*********************************** . .

2. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to NZ_LN868946 (Salmonella enterica subsp. enterica serovar Senftenberg strain NCTC10384 plasmid 4, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatcaag	Protospacer
***********************************.

3. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to KU052038 (Escherichia phage SerU-LTIIb, partial genome) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatatgc	Protospacer
*********************************** . .

4. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to KU052038 (Escherichia phage SerU-LTIIb, partial genome) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatatgc	Protospacer
*********************************** . .

5. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to LN997803 (Escherichia coli phage phi467) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccatatgc	Protospacer
*********************************** . .

6. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to NZ_CP023526 (Cedecea neteri strain FDAARGOS_392 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccagaatg	Protospacer
**********************************   *

7. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to NZ_CP022660 (Salmonella enterica subsp. enterica strain RM11060 plasmid pRM11060-2, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccacttac	Protospacer
**********************************.*. .

8. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to NZ_CP045061 (Salmonella enterica subsp. enterica serovar Muenchen strain LG26 plasmid pLG26p2, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccacttac	Protospacer
**********************************.*. .

9. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to NZ_CP045054 (Salmonella enterica subsp. enterica serovar Muenchen strain LG24 plasmid pLG24p2, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccacttac	Protospacer
**********************************.*. .

10. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to NZ_CP045058 (Salmonella enterica subsp. enterica serovar Muenchen strain LG25 plasmid pLG25p2, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccacttac	Protospacer
**********************************.*. .

11. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to NC_021742 (Serratia liquefaciens ATCC 27592 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagccggcaccaatcaa	Protospacer
*************************.******** **

12. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to MH791411 (UNVERIFIED: Escherichia phage Ecwhy_1, complete genome) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcacaaatcag	Protospacer
******************************** * **

13. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to MH494197 (Escherichia phage CMSTMSU, complete genome) position: , mismatch: 4, identity: 0.897

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcacaaatcag	Protospacer
******************************** * **

14. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to NZ_CP054057 (Scandinavium goeteborgense strain CCUG 66741 plasmid pSg66741_1, complete sequence) position: , mismatch: 5, identity: 0.872

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgattccggtagtcggcaccaaatgc	Protospacer
**********************************  . .

15. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to KY653118 (Morganella phage IME1369_01, complete genome) position: , mismatch: 5, identity: 0.872

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
taggtcaccagttcgactccggtagccggcaccatatta	Protospacer
****************.********.********* .*

16. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to LC494302 (Escherichia phage SP27 DNA, complete genome) position: , mismatch: 7, identity: 0.821

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aaggtcaccagttcgattccggtagtcggcacaaaataa	Protospacer
 ******************************* *  .

17. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to LT603033 (Escherichia phage vB_Eco_slurp01 genome assembly, chromosome: I) position: , mismatch: 7, identity: 0.821

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aaggtcaccagttcgattccggtagtcggcacaaaataa	Protospacer
 ******************************* *  .

18. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to NC_027364 (Escherichia phage PBECO 4, complete genome) position: , mismatch: 7, identity: 0.821

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aaggtcaccagttcgattccggtagtcggcacaaaataa	Protospacer
 ******************************* *  .

19. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to NC_049942 (Escherichia phage JLK-2012, complete sequence) position: , mismatch: 7, identity: 0.821

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
caggtcgccagttcgattccggtagccggcaccatatgc	Protospacer
.*****.******************.********* . .

20. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to MK817115 (Escherichia phage vB_EcoM_phAPEC6, complete genome) position: , mismatch: 8, identity: 0.795

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aatgtcaccagttcgattccggtagtcggcacaaaataa	Protospacer
 * ***************************** *  .

21. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to MH383160 (Escherichia phage UB, complete genome) position: , mismatch: 8, identity: 0.795

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aatgtcaccagttcgattccggtagtcggcacaaaataa	Protospacer
 * ***************************** *  .

22. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to MK327931 (Escherichia phage vB_EcoM_G17, complete genome) position: , mismatch: 8, identity: 0.795

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aatgtcaccagttcgattccggtagtcggcacaaaataa	Protospacer
 * ***************************** *  .

23. spacer 1.1|2931685|39|NZ_CP016351|PILER-CR matches to KM507819 (Escherichia phage 121Q, complete genome) position: , mismatch: 9, identity: 0.769

taggtcaccagttcgattccggtagtcggcaccattctt	CRISPR spacer
aatgtcaccagttcaattccggtagtcggcacaaaataa	Protospacer
 * ***********.***************** *  .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

818482 : 825136

Staphylococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014231006.1\|818482_819622_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.7e-62	41.7
WP_065296421.1\|819639_820890_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	9.5e-99	47.9
WP_014231008.1\|821006_821456_+	transcriptional regulator NrdR	NA	NA	NA	NA
WP_065296422.1\|821462_822581_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	7.5e-47	37.7
WP_020333699.1\|822598_823252_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	3.1e-32	37.0
WP_065296423.1\|823387_824497_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	9.4e-66	39.6
WP_014231012.1\|824665_825136_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	3.7e-32	48.0

DBSCAN-SWA_2

1066332 : 1135205

Tupanvirus(11.76%)

integrase,transposase,protease

attL 1112346:1112361|attR 1144557:1144572

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_025506618.1\|1066332_1066617_+\|transposase	IS3 family transposase	A9YX41	Burkholderia_phage	1.8e-05	29.3
WP_080258209.1\|1066592_1067471_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	3.0e-83	59.4
WP_065296521.1\|1068734_1070027_-\|integrase	site-specific integrase	A0A248SL35	Klebsiella_phage	9.3e-33	28.2
WP_065296522.1\|1070326_1071118_-	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase	NA	NA	NA	NA
WP_065296523.1\|1071219_1072317_+	hypothetical protein	NA	NA	NA	NA
WP_081280711.1\|1072585_1073806_+	isochorismate synthase	NA	NA	NA	NA
WP_155759710.1\|1073802_1075422_+	(2,3-dihydroxybenzoyl)adenylate synthase	A0A2K9KZV5	Tupanvirus	1.8e-12	28.1
WP_065296525.1\|1075473_1076352_+	isochorismatase family protein	NA	NA	NA	NA
WP_065296526.1\|1076385_1080333_+	enterobactin synthase subunit F	A0A2K9KZV5	Tupanvirus	1.6e-91	26.5
WP_065296527.1\|1080325_1081270_+	hypothetical protein	NA	NA	NA	NA
WP_065296528.1\|1081284_1082013_-	4'-phosphopantetheinyl transferase superfamily protein	NA	NA	NA	NA
WP_065296529.1\|1082132_1084094_+	TonB-dependent receptor	A0A0P0I887	Acinetobacter_phage	4.6e-15	34.7
WP_065296530.1\|1084158_1085472_-	HlyC/CorC family transporter	NA	NA	NA	NA
WP_065296531.1\|1085666_1086896_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	5.7e-56	33.9
WP_014231202.1\|1087140_1087803_+	TrkA family potassium uptake protein	NA	NA	NA	NA
WP_065296532.1\|1087799_1089167_+	Ktr system potassium transporter B	NA	NA	NA	NA
WP_065296533.1\|1089436_1092430_+\|protease	M6 family metalloprotease domain-containing protein	NA	NA	NA	NA
WP_065296534.1\|1092589_1094059_+	YdiU family protein	A0A075BSJ0	Microcystis_phage	7.8e-60	36.2
WP_065296535.1\|1094199_1094925_+	response regulator transcription factor	W8CYM9	Bacillus_phage	3.0e-28	33.2
WP_065296536.1\|1094914_1096357_+	HAMP domain-containing protein	NA	NA	NA	NA
WP_065296537.1\|1096518_1097766_+	carbohydrate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014231209.1\|1097848_1098772_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_065296538.1\|1098768_1099626_+	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_014231211.1\|1099631_1100747_+	sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC	G9BWD6	Planktothrix_phage	4.0e-24	33.3
WP_020336137.1\|1101046_1102045_+	TRAP transporter substrate-binding protein	NA	NA	NA	NA
WP_065296539.1\|1102114_1102804_+	TRAP transporter small permease	NA	NA	NA	NA
WP_065296540.1\|1102807_1104169_+	TRAP transporter large permease	NA	NA	NA	NA
WP_020336140.1\|1104465_1105803_-	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_065296541.1\|1105805_1107614_-	sensor histidine kinase	Q8QKV7	Ectocarpus_siliculosus_virus	8.0e-06	23.9
WP_014231219.1\|1108138_1109443_+	trigger factor	NA	NA	NA	NA
WP_014231220.1\|1109548_1110175_+	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	1.1e-63	61.4
WP_014231221.1\|1110245_1111526_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	2.5e-131	57.6
WP_020336143.1\|1111656_1114008_+	endopeptidase La	A0A0R6PGP8	Moraxella_phage	8.0e-224	53.4
1112346:1112361	attL	NA	NA	NA	NA
WP_014231223.1\|1114199_1114472_+	HU family DNA-binding protein	A3E2K9	Sodalis_phage	3.8e-21	58.4
WP_020336144.1\|1114675_1116535_+	peptidylprolyl isomerase	NA	NA	NA	NA
WP_020336145.1\|1116713_1117007_+	ComEA family DNA-binding protein	NA	NA	NA	NA
WP_020336146.1\|1117088_1117640_-	rhombosortase	NA	NA	NA	NA
WP_065296543.1\|1117643_1118267_+	DTW domain-containing protein	NA	NA	NA	NA
WP_065296544.1\|1118263_1119586_-	deoxyguanosinetriphosphate triphosphohydrolase family protein	NA	NA	NA	NA
WP_065296545.1\|1120294_1121239_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_065296546.1\|1121235_1122552_+	trypsin-like peptidase domain-containing protein	NA	NA	NA	NA
WP_065296547.1\|1122544_1123009_+	hypothetical protein	NA	NA	NA	NA
WP_065296548.1\|1123001_1125920_+	hypothetical protein	NA	NA	NA	NA
WP_065297636.1\|1126108_1128253_+	hypothetical protein	A5LH58	Enterobacteria_phage	6.0e-101	33.1
WP_065296549.1\|1128318_1129497_-	hypothetical protein	NA	NA	NA	NA
WP_081280763.1\|1129614_1130868_+	hypothetical protein	NA	NA	NA	NA
WP_065296551.1\|1131074_1131803_+	hypothetical protein	Q7M296	Enterobacteria_phage	7.1e-14	39.8
WP_155759711.1\|1132053_1132506_+	hypothetical protein	NA	NA	NA	NA
WP_065296553.1\|1132564_1133833_+	hypothetical protein	NA	NA	NA	NA
WP_065296554.1\|1133921_1135205_-\|integrase	site-specific integrase	NA	NA	NA	NA
1144557:1144572	attR	NA	NA	NA	NA

DBSCAN-SWA_3

2313728 : 2338572

Vibrio_phage(39.13%)

integrase,transposase

attL 2312467:2312480|attR 2341781:2341794

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2312467:2312480	attL	NA	NA	NA	NA
WP_065297112.1\|2313728_2314637_-	hypothetical protein	K7XS75	uncultured_Mediterranean_phage	1.8e-30	33.8
WP_065297113.1\|2314626_2315073_-	hypothetical protein	NA	NA	NA	NA
WP_065297114.1\|2315072_2315504_-	DUF1320 domain-containing protein	A0A0M3VI88	Ralstonia_phage	2.6e-19	40.9
WP_065297116.1\|2316148_2317042_-	hypothetical protein	L7P7Y9	Pseudomonas_phage	3.7e-73	49.7
WP_065297117.1\|2317088_2317481_-	hypothetical protein	NA	NA	NA	NA
WP_081280736.1\|2317481_2318639_-	hypothetical protein	A0A0C4UQU6	Shigella_phage	1.3e-70	44.1
WP_065297118.1\|2318692_2319199_-	hypothetical protein	NA	NA	NA	NA
WP_065297119.1\|2319207_2319402_-	hypothetical protein	NA	NA	NA	NA
WP_065297120.1\|2319588_2320047_-	phage virion morphogenesis protein	A0A2H4PAM9	Aphanizomenon_phage	7.2e-12	28.9
WP_065297121.1\|2320046_2320244_-	hypothetical protein	NA	NA	NA	NA
WP_065297122.1\|2320253_2321657_-	F protein	A0A2H4IYU7	uncultured_Caudovirales_phage	1.3e-64	47.8
WP_153645804.1\|2321640_2321778_-	hypothetical protein	NA	NA	NA	NA
WP_065297123.1\|2321777_2323358_-	DUF935 domain-containing protein	A0A0C4UQR8	Shigella_phage	2.1e-127	53.8
WP_155759755.1\|2323378_2324896_-	hypothetical protein	M1NVQ0	Vibrio_phage	2.7e-180	64.5
WP_065297125.1\|2324919_2325501_-	DUF3486 family protein	A0A2I7S9D1	Vibrio_phage	4.2e-33	44.2
WP_155759732.1\|2325475_2325643_-	hypothetical protein	NA	NA	NA	NA
WP_065297126.1\|2325658_2325949_-	hypothetical protein	A0A2I7S9D8	Vibrio_phage	1.4e-21	54.3
WP_081280737.1\|2325935_2326262_-	DUF2730 family protein	A0A2I7S9E2	Vibrio_phage	1.4e-09	37.2
WP_065297127.1\|2326258_2326477_-	hypothetical protein	NA	NA	NA	NA
WP_065297128.1\|2326473_2326980_-	hypothetical protein	A0A2I7S9B5	Vibrio_phage	6.5e-22	42.5
WP_155759733.1\|2326961_2327228_-	hypothetical protein	NA	NA	NA	NA
WP_065297129.1\|2327235_2327682_-	hypothetical protein	M4M9N1	Vibrio_phage	4.3e-46	60.0
WP_081280738.1\|2327827_2328250_-	hypothetical protein	A0A0C4UR27	Shigella_phage	1.9e-19	39.4
WP_065297131.1\|2328347_2328884_-	hypothetical protein	C7BGG4	Burkholderia_phage	9.6e-08	32.1
WP_065297677.1\|2328925_2329537_-	hypothetical protein	NA	NA	NA	NA
WP_065297132.1\|2329677_2330205_-	hypothetical protein	A0A2P9JZH6	Alteromonadaceae_phage	3.1e-27	56.0
WP_065297133.1\|2330371_2330947_-	regulatory protein GemA	A0A0C4UQU3	Shigella_phage	7.6e-27	36.8
WP_065297134.1\|2331143_2331590_-	hypothetical protein	M4MHH2	Vibrio_phage	2.0e-35	56.1
WP_065297135.1\|2331582_2331777_-	hypothetical protein	NA	NA	NA	NA
WP_065297136.1\|2331837_2332032_-	hypothetical protein	A0A2I7S9A9	Vibrio_phage	5.5e-06	37.3
WP_065297137.1\|2332028_2332229_-	ANR family transcriptional regulator	NA	NA	NA	NA
WP_065297138.1\|2332240_2332855_-	DUF3164 family protein	M4MHH7	Vibrio_phage	2.8e-72	66.8
WP_025636974.1\|2332842_2333040_-	hypothetical protein	NA	NA	NA	NA
WP_065297139.1\|2333024_2333297_-	hypothetical protein	NA	NA	NA	NA
WP_065297140.1\|2333889_2334402_-	hypothetical protein	NA	NA	NA	NA
WP_025636970.1\|2334412_2335120_-	ATP-binding protein	A0A1B0T6H3	Thiobacimonas_phage	2.1e-31	31.7
WP_081280739.1\|2335182_2337438_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	M4T586	Rhodobacter_phage	2.7e-51	26.7
WP_065297142.1\|2337849_2338572_+	helix-turn-helix transcriptional regulator	A0SML1	Pseudomonas_virus	8.9e-33	36.3
2341781:2341794	attR	NA	NA	NA	NA

DBSCAN-SWA_4

2854709 : 2871932

uncultured_Mediterranean_phage(20.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065297371.1\|2854709_2857292_-\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	2.3e-78	37.9
WP_065297372.1\|2857434_2857902_-	recombination regulator RecX	NA	NA	NA	NA
WP_014232974.1\|2858016_2859063_-	recombinase RecA	A0A2D1GPX2	Mycobacterium_phage	1.4e-111	60.7
WP_020333963.1\|2859253_2859745_-	nicotinamide-nucleotide amidase	B5TK85	Pseudomonas_phage	1.4e-26	46.8
WP_065297373.1\|2859829_2862391_+	DNA mismatch repair protein MutS	A0A1V0SGG8	Hokovirus	1.6e-31	23.6
WP_081280750.1\|2863533_2864457_-	peptidoglycan DD-metalloendopeptidase family protein	D7RWE0	Brochothrix_phage	1.8e-06	36.4
WP_014232979.1\|2864470_2865097_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	6.7e-37	52.7
WP_014232980.1\|2865096_2865873_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	1.7e-66	50.6
WP_020333968.1\|2865872_2866916_-\|tRNA	tRNA pseudouridine(13) synthase TruD	NA	NA	NA	NA
WP_014232982.1\|2866958_2867438_-	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	NA	NA	NA	NA
WP_065297375.1\|2867451_2868159_-	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	A0A2H4UTB4	Bodo_saltans_virus	3.1e-06	26.2
WP_014232984.1\|2868160_2868442_-	cell division protein FtsB	NA	NA	NA	NA
WP_014232985.1\|2868908_2870210_-	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	2.7e-136	60.3
WP_020333971.1\|2870291_2871932_-	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	6.5e-156	52.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP016352

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP016351

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection