CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP016396	Mycobacterium avium strain RCAD0278, complete genome	5 crisprs	cas3,DinG,DEDDh,csa3,RT,cas4,WYL	0	3	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP016396_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016396_1

449083-449166

Orphan

Consensus_repeat	Method
CGGCCGGCGCCCGAGTTGTCGGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016396_1

>merge|NZ_CP016396|1|449083-449166|CRISPRCasFinder
CGGCCGGCGCCCGAGTTGTCGGCCGGCGCCCGAGTTGTCGGCCGGCGCCCGAGTTGTGTCGGCCGGCGCCCGAGTTGTCGGCCG

>NZ_CP016396|1|1|449083-449166|CRISPRCasFinder
CGGCCGGCGCCCGAGTTGTCGGCCG	GCGCCCGAGTTGTCGGCCGGCGCCCGAGTTGTGT
CGGCCGGCGCCCGAGTTGTCGGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016396.1\|WP_009975672.1\|449230_449722_-\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|239474
NZ_CP016396.1\|WP_065370737.1\|440632_442372_+\|potassium-transporter-TrkA	unknown	unknown	gnl\|CDD\|367001
NZ_CP016396.1\|WP_010949617.1\|447526_448471_-\|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl\|CDD\|235375
NZ_CP016396.1\|WP_009975682.1\|442396_443269_-\|tetratricopeptide-repeat-protein	unknown	unknown	unknown
NZ_CP016396.1\|WP_009975678.1\|445132_445618_-\|RrF2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|273242
NZ_CP016396.1\|WP_009975685.1\|440167_440539_+\|steroid-Delta-isomerase	unknown	unknown	gnl\|CDD\|238404
NZ_CP016396.1\|WP_009975663.1\|456581_459212_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|227061
NZ_CP016396.1\|WP_009975670.1\|449870_450845_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP016396.1\|WP_003877279.1\|444740_445136_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319939
NZ_CP016396.1\|WP_029248423.1\|463698_464202_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|224973
NZ_CP016396.1\|WP_023884162.1\|445676_447527_-\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|180120
NZ_CP016396.1\|WP_009975679.1\|444275_444689_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NZ_CP016396.1\|WP_065370738.1\|453610_455287_+\|ABC-transporter-family-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173866
NZ_CP016396.1\|WP_009975661.1\|459208_460360_-\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|223497
NZ_CP016396.1\|WP_003875595.1\|448690_449080_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP016396.1\|WP_023879803.1\|451764_453600_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|182342
NZ_CP016396.1\|WP_011724138.1\|455273_456518_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP016396.1\|WP_024636893.1\|450892_451768_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP016396.1\|WP_080555769.1\|460606_462019_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP016396.1\|WP_009975681.1\|443330_444209_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009

Protein	Function_ID	Function_description	E-value
NZ_CP016396.1\|WP_009975672.1\|449230_449722_-\|carbonic-anhydrase	gnl\|CDD\|239474	cd03379, beta_CA_cladeD, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	5.57609e-66
NZ_CP016396.1\|WP_065370737.1\|440632_442372_+\|potassium-transporter-TrkA	gnl\|CDD\|367001	pfam02254, TrkA_N, TrkA-N domain. This domain is found in a wide variety of proteins. These protein include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.	3.81128e-18
NZ_CP016396.1\|WP_010949617.1\|447526_448471_-\|sulfate-adenylyltransferase-subunit-CysD	gnl\|CDD\|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0
NZ_CP016396.1\|WP_009975663.1\|456581_459212_-\|AAA-family-ATPase	gnl\|CDD\|227061	COG4717, COG4717, Uncharacterized conserved protein [Function unknown].	1.93303e-09
NZ_CP016396.1\|WP_009975678.1\|445132_445618_-\|RrF2-family-transcriptional-regulator	gnl\|CDD\|273242	TIGR00738, Putative_HTH-type_transcriptional_regulator, Rrf2 family protein. This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General].	4.4521e-50
NZ_CP016396.1\|WP_009975685.1\|440167_440539_+\|steroid-Delta-isomerase	gnl\|CDD\|238404	cd00781, ketosteroid_isomerase, ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon. Ketosteroid isomerases are important members of this class of enzymes which are the most proficient of all enzymes known and have served as a paradigm for enzymatic enolizations since its discovery in 1954. This CD includes members of this class that calalyze the isomerization of various beta,gamma-unsaturated isomers at nearly a diffusion-controlled rate. These enzymes are widely distributed in bacteria.	5.24107e-32
NZ_CP016396.1\|WP_009975670.1\|449870_450845_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	9.98974e-98
NZ_CP016396.1\|WP_003877279.1\|444740_445136_+\|VOC-family-protein	gnl\|CDD\|319939	cd08351, ChaP_like, ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins. ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	1.75777e-66
NZ_CP016396.1\|WP_029248423.1\|463698_464202_+\|histidine-phosphatase-family-protein	gnl\|CDD\|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	1.90571e-43
NZ_CP016396.1\|WP_023884162.1\|445676_447527_-\|adenylyl-sulfate-kinase	gnl\|CDD\|180120	PRK05506, PRK05506, bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional.	0
NZ_CP016396.1\|WP_009975679.1\|444275_444689_+\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	1.10594e-13
NZ_CP016396.1\|WP_065370738.1\|453610_455287_+\|ABC-transporter-family-substrate-binding-protein	gnl\|CDD\|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.7347e-161
NZ_CP016396.1\|WP_009975661.1\|459208_460360_-\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	4.49131e-63
NZ_CP016396.1\|WP_003875595.1\|448690_449080_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	7.96357e-32
NZ_CP016396.1\|WP_023879803.1\|451764_453600_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|182342	PRK10261, PRK10261, glutathione transporter ATP-binding protein; Provisional.	1.49388e-169
NZ_CP016396.1\|WP_011724138.1\|455273_456518_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.18804e-13
NZ_CP016396.1\|WP_024636893.1\|450892_451768_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.57881e-85
NZ_CP016396.1\|WP_080555769.1\|460606_462019_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	8.54636e-20
NZ_CP016396.1\|WP_009975681.1\|443330_444209_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	3.19761e-32

>NZ_CP016396.1|WP_003875595.1|448690_449080_+|PaaI-family-thioesterase
MIAQFLPQSPFVVKLGIVAERLDEDEVRLRLPWDPSNVTIGDMVHGGAIATLADLTVMAAAWCGAQAPPQLRGVTVSMALDFMAPARASDVIGVGRVLRRGRSLVNCEAEIVDPQGTLVAKALATYKVG
>NZ_CP016396.1|WP_010949617.1|447526_448471_-|sulfate-adenylyltransferase-subunit-CysD
MPKEAMTADLQTAPAAGQYELSHLRSLEAEAIHIIREVAAEFERPVLLFSGGKDSIVMLHLALRAFRPGRLPFPVMHVDTGHNFDEVIATRDELVKQHGLRLVVASVQDDIDAGRVVEPKQGRNPIQTVTLLRAIRENKFDAAFGGARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEFDIWSYIGAENIALPSIYYAHRRKVFRRDGMLLAVDRNMQPNPDEPVFEATVRFRTVGDVTCTGCVESQAATVDEVIAETAVSRLTERGATRADDRISEAGMEDRKRQGYF
>NZ_CP016396.1|WP_023884162.1|445676_447527_-|adenylyl-sulfate-kinase
MAAPTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWAAVEQTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIQHIVLAVNKMDLIGWDREKFESIRDEFHAFAARLDVHDVATIPISALHGDNVVTKSDQTPWYEGPALLSHLEEVYIAGDRNLVDVRFPVQYVIRPHTHEHQDHRSYAGTVASGVMRPGDEVVVLPVGKRTRITAIEGPNGPVQEAFPPMAVSLTLADEIDISRGDLIARTHNQPRIAQDFDATVCWMADNTTLEPGRDYVIKHTTRTTHARVTGLDYRLDVNTLHRDKTATALKLNELGRISLRTQVPLLLDEYTRNPSTGSFILIDPHTNGTVAAGMVLRDASAQAASPNTVRHKSSAIAAARPRGKTVWFTGLSGSGKSSVAMLVEQKLLEKGAQAYVLDGDNLRHGLNADLGFSMADRAENLHRLAHVAALLADCGNVVLVPAISPLAEQRELARKVHADAGFDFIEVFCDTPIEECEKRDPKGLYAKARAGEITQFTGIDSPYQPPAKPALRLTPDGTVEEQAQRVIDLLESRG
>NZ_CP016396.1|WP_009975678.1|445132_445618_-|RrF2-family-transcriptional-regulator
MRMSAKAEYAVRAMIQLATVPDGTLVKTDDLAQAQGIPPQFLVDILTNLRTDRLVRSHRGREGGYELARPGKDISIADVLRCIDGPLASVRDIGLGDLPYSGPTAALTDVWRALRASMRLVLEETTLADVATGSLPKHVAQLADDYRKQESQRHGTARTGD
>NZ_CP016396.1|WP_003877279.1|444740_445136_+|VOC-family-protein
MTISFNHTIVASRDKRESAEFLAELFDLPGPKPFGHFMVVELDHGASLDYADAPDGADIPRQHYAFLVSEQEFDTIYGKIRARGLEHWADPGARRPGEINHNDGGRGVYFLDPSGHAMEILTRPYGSGAAN
>NZ_CP016396.1|WP_009975679.1|444275_444689_+|VOC-family-protein
MGLTNTSIAHVRLTVTDIEQSRRFYESVFGWPVLLEVPDNADASTREQLSFLFGGVIYDLGGTLLGLRPVATDRFDEDRTGLDHIAFRLDSRDELDAAAAHLDELGVAHEPVKDIGPAYILQFRDPDNIALELTAPK
>NZ_CP016396.1|WP_009975681.1|443330_444209_-|LLM-class-flavin-dependent-oxidoreductase
MTMPVMEPDLDATVLETWARTIDEGPFSSLCWGERIAFDNPDSLTLLGALAAWTERVRLLTTVIVPQLHDPVLLAKGLATGDLLSGGRLSVGIGVGGRQEDYHAVGADPATQTMRGMAERVAVMKRVWAGEKLTESVLPVGPAPVQPGGPPLFVGSIGPKTIRSAAAWADGLAGTTLDLDVAKQRELFDVTRDAWARAGKPAPHLITSFWFAFGSPRTAREQVHRHLRRYMNWIPADYVDAMAPMTGWAGDEDELAEVLRKFAGIGADEVQLIPTSSDVGQLRRAADVAARL
>NZ_CP016396.1|WP_009975682.1|442396_443269_-|tetratricopeptide-repeat-protein
MTQQELPAPLAELTGLLTECTNKGDFVGAARQAGELVTLCRATLGERHPTALELKVSLATLRLRAGECAVAYEEFERLIPDLVEVLGPDHLSTLTARHLLASRQQAALSSLAEWSQLFADEQRVWGADHENTLVAREKIAEKRWEIGDFVGAMAEGEQVLAARRRVLGADHTDTLGTQLMLSIWRGRAGDVPAAVAELEPLIGELREKLGDDHAHVLMARHMFTLWAPERAGVTDAVAAWEALVEEESRVLGDEHPVTLAARQELAGWCARRDGQAGGAGAQGSLDWSAS
>NZ_CP016396.1|WP_065370737.1|440632_442372_+|potassium-transporter-TrkA
MRDDSPRMSPRRHIIVSGDDVLATTIAEELNRAGATIVKLPSEELAGADLARASAIVCAGRDDAKNLEIALLARKTNPHVRVVARLGNDVLRGAVAADNGPGAILDVADLAAPSVVEACLSSSTHPVRAAGIDFLVSGAEAPRDATLREIYGDLAPVAVIHGNDGATPGEVVPCPGRDHRVRAGDWTAMIGSADELAARGIRTPRPPATRSRQTWLRRVLDAARAMRDDVNPMLFPAILLALTLLLVSTVIVHFSYTKPRLSWLDALYFTAETITTVGYGEFTFAHQSAWLRIFAVGLMFAGVTTTALLVAFLADLLLSRRFLQSAGLRRARHLRNHIIGQGSFGSRVVADLTAAGYDVAVIERDENNRFLSTAAELDVPVIFGDATLRQTLESARVDRARAVAVLTQDDMVNIEIGIVLREMLGPRVMPEVNRPDVPIVLRIYDRTLGDAVAKRFGFENVRSTVDLAAPWFIGAAMGLQVLGTFSVGQRSFMVGAMHVAAGSELDGLRMFEMSTQTRVIAITRRDTPVELHPRRDAWLRAGDTVYLVGPYRELLETLRKGQPPQQPANEERPADKATT
>NZ_CP016396.1|WP_009975685.1|440167_440539_+|steroid-Delta-isomerase
MPSAEAITDTVNRYLALVATGTADDIVTLYAADATIEDPIGADIRRGHDAIRAFYAGFQDAKKDTELAELRVSGSEAAFLWHLTLDAGDTRTRISPISTMSFDEDAKITAMRAFWSPTDVQVL
>NZ_CP016396.1|WP_009975672.1|449230_449722_-|carbonic-anhydrase
MAVTDDYLAHNAGYARSFEGPLPMPPSKHVAVVACMDARLDVYRILGLREGEAHVIRNAGGVITDDVVRSLAISQRLLGTREIILIHHTDCGMLTFTDDDFKRGIQEETGIKPPWAAEAFADLAEDVRQSLRRIEANPFVTKHVSARGFVFDVATGKLDEVKP
>NZ_CP016396.1|WP_009975670.1|449870_450845_+|ABC-transporter-permease
MTRFLARRLLNYLVLLALASFLTFCLTSVAFKPLDSLLQRSPRPPQAVIDAKAHSLGLDEPIPIRYAHWASHAVRGDFGKTVTGQPVGASLGRRVGVTLRLLVIGSLIGTVAGIAAGAWGAIRQYRLSDRVVTMLALLVLSTPTFVIASLLILAALRVNWALGVQVFDYTGETSPGVTGGAAALLDRLRHLVLPSLTLALAAAAGYSRYQRNAMLDVLGQDFIRTARAKGLTRRRALVKHGLRTALIPLATLFAYGVAGLVTGAVFVEKIFGWHGMGEWLVQGVATQDTNIVAAITLFSGAVVLLAGLLSDVFYAALDPRVRVS
>NZ_CP016396.1|WP_024636893.1|450892_451768_+|ABC-transporter-permease
MAGFASRRTLVLRRFGRNRLAVTSLTLLVLLFVGCYTLPAVLPYSYQDLDFDALLQPPNARHWLGTNALGQDLLAQILRGMQKSMLIGVCVAVISTGIAATVGSIAGYFGGWRDRVLMWLVDLLLVVPSFILIAIVTPRTKNSANILMLVLLLAGFGWMVSSRMVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVASAILAETGLSFLGFGVQPPDVSLGTLIANGTQSATTFPWVFLFPAGVLVLILVCANLTGDGLRDALDPGSGPARGGRR
>NZ_CP016396.1|WP_023879803.1|451764_453600_+|ABC-transporter-ATP-binding-protein
MSPLLQVTDLAVTFPAGDAPVTAVRGISYRIEPGEVVAMVGESGSGKSVSAMAVMGLLPEHARVRGSVRLHDTELLGLGDDAMSRLRGRAVGMVFQDPMSALTPVYTVGDQIAEAITIHQPRVGRKAARDRAVELLELVGIAQPQRRARAFPHELSGGERQRVVIAIAIANDPDLLICDEPTTALDVTVQAQILEVLKTARDITGAGVLIITHDLGVVAELADRALVMYAGRVVESAAVASLYRDRRMPYTVGLLGSVPRLDAAQGTRLVPIPGAPPSLAGLDPGCPFAPRCPLAIDECRSQEPELLPVGPDHRAACIRTDQVDGRSAADIYGVRTQPHPGEPANSPVLVRVRELSKTYRLTKGVLRRSAGEVRAVDRISFQLRQGRTLGIVGESGSGKSTTLHEILELVAPQSGSIEVLGTDVAALSPASRRSLRRDIQVVFQDPVASLDPRLPVFELLAEPLRANGFDKDHTNARVAELLETVGLRRADAARYPAEFSGGQKQRIGIARALALQPKILALDEPVSALDVSIQAGIINLLLDLQAQFQLSYLFVSHDLSVVKHLAHDVAVMYAGSIVEQGDSSQVFGNPQHEYTRRLLDAVPQPNPGSRG
>NZ_CP016396.1|WP_065370738.1|453610_455287_+|ABC-transporter-family-substrate-binding-protein
MGRCGFRPAALVAAVVLAVAGCSPAINLVPETGQNARIGTTSDINPRDPATLQDGGNLRLALTDFPPNFNILHIDGNSADVSAMMKATLPRAFVIGPDGSTTVDTDYFTSVELTGTAPQVVTYTINPKAVWSDGTPITWEDIASQIHALSGVDKTFEIAGSSGAERVASVTRGVDDRQAVVTFAKPYAEWRGMFAGNGMLLPKSMTATPEAFNKGQLEGPGPSAGPFIVSSLDRTTQRIVLSRNPKWWGTRPRLDSITYLVLDDAARLPALQNNTIDATGVGTLDQLTIAEHTAGISIRRAPAPAWSHFTFNGAPGSILADRALRVAVSKGIDRQTIAKVVQYGLTSNPVALGNHIYVAGQQGYQDNSTTVPYDPAAAGRELDALGWKLHGRFREKDGRQLVIRDLFYDAQGSRQFAQIAQHSLAQIGVRLELVARAGSGFFTNYINVGAFDMAQFGWLGDAFPLSALTQIYKSDGESNFGKIGSPQIDAAIERTLQELDPDKARALANDLDKLIWAEGFSLPLTQSPGDVAVRSTLANFGAAGLGDLNYTAIGFTRS
>NZ_CP016396.1|WP_011724138.1|455273_456518_-|alpha/beta-fold-hydrolase
MTMNAKRRRMQQRLAKLPGVRAVRRPISPDTADEFDLYYVRAGRKSRHPVVIIPGGPGVASVQMYKGLRRRAAAAGLDVIMIEHRGVGMSRHDDAGADLPPEAMTVNQVVDDVAAVLDDARVDSAVVYGASYGTYIASGVGVRHPARVHGMVLDSPLLSRHDIVIVRRAIRRLLLRGDSPETASLAPKMRKLVDAGLMTATATQVVATIYGYGGARLLERQLDLLLDGRKLLWWTLSRFTTLRNLPFRYEEDLVSRIALRELDYAAEPDGLPLDPAVAEREVRTQTATFEDEPYDLPAEMPSFDWPTAVVSGGRDLITPPAVAERVASLLPHAVLLSLPDMAHSALDFHEAVALASADAVLRGDLAGLAARACTLNALPPRPEVRLLWALIAAAAMIEGALPIPAPLRRRLSCG
>NZ_CP016396.1|WP_009975663.1|456581_459212_-|AAA-family-ATPase
MKLHRLTLTNYRGIAHREIEFPDHGVVVVCGANEIGKSSMIEALDLLLEAKDRSTKKEVKQVKPTHSDVGAEVSAEISCGPYRFVYRKRFHKKCETELTVITPYREQLTGDEAHERVRAMLAETVDSDLWHAQRVLQAASTAAVDLSGCDALSRALDVAAGDSGGLCGTEPLLIERIDAEYARYFTPTGRPTGEWAAAIARLADAEAAVAECAAAVAEVDERVSRHAALTEQVADLSQRRIAAGPRVTAARQAADRIAELTAQRREAQLVAEAAAATKAAAAQAHSGRLQLLADIDSRAAAVTQTQAQVQQAAADHAAARADAQACDTALQHATEALAELERRVQEAQRTVERLAGREEADRLAARLDKIDAIQRDRERISAELSTIAVTEELLRRIEDAAAAVDRIGDQLASTSAAVEFTAVADIHLVIGDRQVSLPAGQSWSITAVGPTAVEVPGVLTARVIPGATTLDVQAKHAAAQQELAAALMAGAVADLAAARSADQRRRELQGTRDQLGATLAGLCGDEPHDELRSRLARLRAEHPEQPAEPTGGAADLAAARTELETLAQARACASAECDTHRQAATAAAARLAETATAATVLQNRLDTLRAELDAATGRLAAERASVGDEELAASADAALRAEQAAERRVAELADALAAASPDSVAAELADATQESESLRERYEEAAGALREVTIELSVFGSEGRQGKLDAAETEREHAASEHSQVGRRARAAQLLRSVMTRHRDTTRQRYVEPYRAELQRLGRPVFGPTFEVDIDSDLCIRSRTLNGITVPYESLSGGAKEQLGILARLAGAALVAKEDAVPVVVDDALGFTDPDRLAKMGQLFDSVGSHGQVIVLTCSPDRYDGVKGAHRIDLSA
>NZ_CP016396.1|WP_009975661.1|459208_460360_-|exonuclease-SbcCD-subunit-D
MRFLHTADWQLGMTRHFLAGDAQPRYSAARRDAVAGLGALAAEVGAEFVVVSGDVFEHNQLPPKVVGQSLEAMRAIGIPVYLLPGNHDPLDASSVYTGALFTAERPHNVTVLDRAGVHQVRPGLQLVAAPWRSKVPTTDLVGEVLDGLPETDDTRILVGHGGVDVLDPDRDKPSLIRLAKLEDALTRGAVHYVALGDKHSLTQVGSSGRVWYSGSPEVTNFDDVEADPGHVLIVDIDEADPRRPVSVTARRIGCWRFVTLHRQVDSSRDIADLDMNLDLMTNKDRTVVRLALTGSLTVTDRAALDACLDKYARLFAHLRTWDSHTELAVIPADGEFSDLGIGGFAAAAVEELVATARQQDSDTAADAQGALALLLRLADRGAA
>NZ_CP016396.1|WP_080555769.1|460606_462019_-|IS110-family-transposase
MCVELILGIDVACRAAHQASLARPDGTYVWTGRKFFTRPADLEKLWKVIGLSEQDTVRVVMEPTRNAWVPLASWFRHHGARISMVPTTQSADLRAYYSKHTKNDHLDSKLLARLPLLHPEGLRDHSGDGPGEPLRRLVKIRSSIVKRRTAVFQRLDAQLELLGPAWYDALGSNYGKAALALLARYADPHSLIRLGHARLTRFLIRHSRGAWREPHATLLLTAAQESLQLWGSGANARIDFAELAADIATEAEQAQMLTEQIDDLDERAANLYAEADPRGIIASAPGVGPVTCAVIAGRIGDPHRFHSLAAIRAYSGLVPKVNQSGQAEQRHGLTKAGDPLLREALFAAADQARKSDPQLAAKYKRLMSTERHHDSAICHIATILLTRIATCWRAGAHYVLRDTDGRPITFEEGRRIVRAHHTVDKKTRINAASKRYSQRQKGRTGREQQESLRAPIHRPVHPSIKPTEVA
>NZ_CP016396.1|WP_029248423.1|463698_464202_+|histidine-phosphatase-family-protein
MTGRRTLLLMRHAKSDYPDGVADHDRPLAPRGIRQAGLAGDWLRAGAPAIDGVLCSTATRTRETLRNTRIEAPVRYSERLYASTPGIVIDEINTVGDDVSTLLVIGHEPTMSALALGLGGGSGANPAAAERVSNKFPTSAIAVLAVPCRWTELELGAATLTDFVVAR

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Crispr_ID: NZ_CP016396_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016396_2

1942994-1943070

Orphan

Consensus_repeat	Method
GCGCGCCCATGGCGCTCGTCGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016396_2

>merge|NZ_CP016396|2|1942994-1943070|CRISPRCasFinder
GCGCGCCCATGGCGCTCGTCGCGCCCCTCAGGGGCCGACGGTTCGGCTTGCTCCTCGCGCCCATGGCGCTCGTCGCG

>NZ_CP016396|2|2|1942994-1943070|CRISPRCasFinder
GCGCGCCCATGGCGCTCGTCGCG	CCCCTCAGGGGCCGACGGTTCGGCTTGCTCC
TCGCGCCCATGGCGCTCGTCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016396.1\|WP_009979740.1\|1955221_1955470_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016396.1\|WP_065370890.1\|1944684_1946250_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_CP016396.1\|WP_023879447.1\|1953515_1954001_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NZ_CP016396.1\|WP_003874123.1\|1938108_1938663_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016396.1\|WP_009979729.1\|1936656_1937322_-\|DUF1275-domain-containing-protein	unknown	unknown	gnl\|CDD\|377734
NZ_CP016396.1\|WP_011726378.1\|1933267_1933993_+\|pirin-family-protein	unknown	unknown	gnl\|CDD\|380375
NZ_CP016396.1\|WP_011726377.1\|1932351_1933242_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP016396.1\|WP_023883898.1\|1934051_1935518_+\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
NZ_CP016396.1\|WP_009979734.1\|1939627_1940329_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016396.1\|WP_003874164.1\|1949464_1950280_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223838
NZ_CP016396.1\|WP_009979735.1\|1940298_1941849_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|224380
NZ_CP016396.1\|WP_003874163.1\|1948593_1949463_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223838
NZ_CP016396.1\|WP_009979731.1\|1937386_1938142_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP016396.1\|WP_003874167.1\|1953031_1953472_-\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176861
NZ_CP016396.1\|WP_023880818.1\|1938659_1939631_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP016396.1\|WP_085978618.1\|1935554_1936664_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378342
NZ_CP016396.1\|WP_011726386.1\|1943074_1944688_-\|virulence-factor-Mce-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_CP016396.1\|WP_003874130.1\|1946246_1947287_-\|virulence-factor-Mce-family-protein	unknown	unknown	gnl\|CDD\|273384
NZ_CP016396.1\|WP_065371192.1\|1954015_1955128_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176241
NZ_CP016396.1\|WP_065370891.1\|1947283_1948588_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|378749

Protein	Function_ID	Function_description	E-value
NZ_CP016396.1\|WP_023883898.1\|1934051_1935518_+\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	8.00922e-50
NZ_CP016396.1\|WP_009979729.1\|1936656_1937322_-\|DUF1275-domain-containing-protein	gnl\|CDD\|377734	pfam06912, DUF1275, Protein of unknown function (DUF1275). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although most members have 6 TM regions, and may be putative permeases.	1.87337e-27
NZ_CP016396.1\|WP_011726378.1\|1933267_1933993_+\|pirin-family-protein	gnl\|CDD\|380375	cd02910, cupin_Yhhw_N, Escherichia coli YhhW and YhaK and related proteins, pirin-like bicupin, N-terminal cupin domain. This family includes the N-terminal cupin domains of YhhW and YhaK, Escherichia coli pirin-like proteins with unknown function. YhhW is structurally similar not only to human pirin but also to quercitin 2,3-dioxygenase (quercitinase). Although the function of YhhW is not completely understood, YhhW and its human ortholog have quercitinase activity and are likely to play an important role in transcription and apoptosis. This N-terminal cupin domain of YhhW has a metal coordination site and is thought to have catalytic activity while the C-terminal cupin-like domain has diverged considerably and has closer alignment with C-terminal pirin. YhaK is found in low abundance in the cytosol of E. coli and is strongly up-regulated by nitroso-glutathione (GSNO). There are major structural differences at the N-terminus of YhaK compared with YhhW; YhaK lacks the canonical cupin metal-binding residues of pirins and may be involved in chloride binding and/or sensing of oxidative stress in enterobacteria. YhaK showed no quercetinase and peroxidase activity; however, reduced YhaK was very sensitive to reactive oxygen species (ROS). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	4.76718e-72
NZ_CP016396.1\|WP_011726377.1\|1932351_1933242_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	8.76371e-17
NZ_CP016396.1\|WP_065370890.1\|1944684_1946250_-\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	7.87823e-82
NZ_CP016396.1\|WP_003874167.1\|1953031_1953472_-\|SRPBCC-family-protein	gnl\|CDD\|176861	cd07819, SRPBCC_2, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	4.15327e-44
NZ_CP016396.1\|WP_003874164.1\|1949464_1950280_-\|ABC-transporter-permease	gnl\|CDD\|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	1.098e-87
NZ_CP016396.1\|WP_009979735.1\|1940298_1941849_-\|MCE-family-protein	gnl\|CDD\|224380	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism].	2.15457e-77
NZ_CP016396.1\|WP_003874163.1\|1948593_1949463_-\|ABC-transporter-permease	gnl\|CDD\|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	9.52641e-81
NZ_CP016396.1\|WP_009979731.1\|1937386_1938142_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00629665
NZ_CP016396.1\|WP_023879447.1\|1953515_1954001_-\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	2.43707e-35
NZ_CP016396.1\|WP_023880818.1\|1938659_1939631_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	1.49912e-13
NZ_CP016396.1\|WP_085978618.1\|1935554_1936664_+\|hypothetical-protein	gnl\|CDD\|378342	pfam09992, NAGPA, Phosphodiester glycosidase. This is a family conserved from bacteria to humans. The structure of a member from Bacteroides has been crystallized and modelled onto the luminal region of the human member of the family, the transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. There is some conservation of potentially functional residues, implying that in the bacterial members this family acts in some way as a phosphodiester glycosidase. The human protein is also present, so the eukaryotic members are likely to be catalyzing the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides.	0.000457806
NZ_CP016396.1\|WP_011726386.1\|1943074_1944688_-\|virulence-factor-Mce-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	8.2028e-90
NZ_CP016396.1\|WP_003874130.1\|1946246_1947287_-\|virulence-factor-Mce-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	4.72889e-88
NZ_CP016396.1\|WP_065371192.1\|1954015_1955128_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176241	cd08281, liver_ADH_like1, Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase). NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. This group contains members identified as zinc dependent alcohol dehydrogenases (ADH), and class III ADG (aka formaldehyde dehydrogenase, FDH). Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. Class III ADH are also know as glutathione-dependent formaldehyde dehydrogenase (FDH), which convert aldehydes to the corresponding carboxylic acid and alcohol. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.15637e-150
NZ_CP016396.1\|WP_065370891.1\|1947283_1948588_-\|MCE-family-protein	gnl\|CDD\|378749	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative. Mce4_CUP1 is a family of putative Mce4 transporters of cholesterol. The domain is found associated with pfam02470. The full TCDB classification for this family in conjunction with PF02470 is TC:3.A.1.27.4.	2.84668e-104

>NZ_CP016396.1|WP_009979735.1|1940298_1941849_-|MCE-family-protein
MLTPFVRRQLVAFGILTVISLLVLGIYYLQIPSLVGIGRYTLKAELPASGGLYPTANVTYRGITIGKVTDVEPTEHGAEATMSIDSHYKIPIDAVANVHSVSAVGEQYLDLVSSGNPGKYLSSGQTITKGTVPAEIGPALDTANRGLAVLPKEKIGQLLDETAQSVGGLGPNLQRLVDATQAIVGDFKNQITDVNDIIEHSGPVIDSQVKSGDAIERWARNLNRLGAQSAQEDSHLKSLLRQAGPTADQVNDVFNDVRESLPQTLANLEVVIDLLKRYHTGVEQVLVFLPQGASIAQTVAAPFPNMAALDLALSINQPPPCLTGFIPASEWRSPADTSLQPLPTGTYCKIPMDTPANSVRGSRNIPCTDIPGKRAATPRECRDPKPYVPAGTNPWYGDPNQILTCPAPAARCDQPVKPGMVIPAPSVDNGLNPAPSDRVAGTPPPVSDPLSRPGSGTVQCNGQQPNPCVYKPSGPPTAVYSPQSGELVGPDGVKYSVENSTRTGDDGWKEMLAPAG
>NZ_CP016396.1|WP_009979734.1|1939627_1940329_-|hypothetical-protein
MEGDAGASRLNPIDTDDDSLSPQDKDEDSTAPASTDEQTGSQGAPGVAGESAPDDADDAVPVAAVPRGPSRLGRGWLAAIAAVLVLCAAGIGAGGYLALRYHHESQVIARNNAAALKAAVDCVEATQAPDTNAMTASEQKIIDCGTDAYRSQALLYTSMLVQAYQSANIHVQVSDVRAAVERNNPDGSIDILVALRVKVASDQSQNESGYRLRVKMALAEGQYKISKLDQVTK
>NZ_CP016396.1|WP_023880818.1|1938659_1939631_-|RDD-family-protein
MTVLVEQTATMGTPEPVREALAPWHSRVGAFAIDVAPGAAVIATMALVSFTVPARGVWWWVGVCVLGVVTLLALVNRLLLPVITGWSLGRALAGIAVTRRTGAAPGPWRLLLRDLAHLLDTASIVGWLWPLWDSRRRTFADMLAGTEVRRLAPEQVPPHITRWAAAAVLGAAAVCLGGAAMSYGVVYSADRASDQTRAQIATQGPKIVAQMLTYDPKSLHDDFARAQSLATDKYRRQLQTQQDVVQKGNPVINEYWVTNSSIESASRDRATMLLFMQGRRGAAPEVRYISATVRVSFAKVGENTWRVDDLTVLTKPKPPGGAK
>NZ_CP016396.1|WP_003874123.1|1938108_1938663_-|hypothetical-protein
MSPRRKFAPGERPLLVARPVRPPRGWLLPLAGTAAALLMVTAVTLCALMLVSHESRERAASKDREVLSYVSGFMTQFTSIDPFHANDYVNRILAQATGDFAKQYEKNANEILLQVARAEPATGTVLDAGLERWNDDGSANVMVATAITTKSPDEKQVLENTNRWAATATQEGNQWKISSLQQVI
>NZ_CP016396.1|WP_009979731.1|1937386_1938142_-|hypothetical-protein
MEDQQPAAGDLTAEENPAADQNEATVAAAGDDRENGDAATESEAAKTSDAAPADGAEDSHSAETVETAGAAPAAGRRTKRLAGKAWAVAAMVAALLFVGSAGFAGAMVQPYLADRAVAATKLKVARTAANAITTLWTYTPENMDTLADRASAYLSGDFEAQYRKFVDAIVAPNKQAKITNHTDVTGAAVESLDDTNAVVIVYTNTTSTSPLTKNVPSLKYLSYRLFMKRAKSRWLVTRMTTITSLDLTPKV
>NZ_CP016396.1|WP_009979729.1|1936656_1937322_-|DUF1275-domain-containing-protein
MAALLLLTFATGLADAISILVLGHVFVANMTGNVIFLGFWLAPRTSIDLTAVVVALPTFACTTILSGRLARHFGERVRAWISTVLATEIVLLVGLSVLAGSGILSYQQDSKLLMIGILAVTFGLQHSSARQFGIQEFSTTVLTSTIVSLGLDSRLAGGSGERQRLRIGVVATMCAGAFLGATMSRYVVAPVFVVAAAVIAASLLIFRFGPPAAKPAAAEAN
>NZ_CP016396.1|WP_085978618.1|1935554_1936664_+|hypothetical-protein
MHFMAERAIVLTRRASFRRLAACCTALSACLTLAVTSGQPLARAADGRDLLANAISSTRGSYLVYNFGPGHPAPMLNAGGSWYEMNNGGHLMIIKNAAGRLSPHLLVDTHQGDQARCENNPGARTAEGLWQASELYAPLQAWQRMGQPTIAINANFFDVRPQKGGSWRQTGCSSPLGAFVDNTNGRGRANQAVTGTVAYPGKQGLSGGGESWSALTTMILPSGGAPYVVWPKTKSDYDAATPVVADLLNKNEKFVAVSGIGLLAPGNTGQLHDGGPSAARTAIGYARQKDEMYIFEGGSYTPDNMQDLFRGLGSDNAVLLDGGGSSAIVLRRDTGGMWAGAGSPRGSCDTRQVLCDSHERALPSWLAFN
>NZ_CP016396.1|WP_023883898.1|1934051_1935518_+|YhgE/Pip-domain-containing-protein
MARSHPQHAAPNPNRNIKAVRTVRFWAAPLVITLALMSALCALYLGGILNPTTNLRHFPIAVVNEDAGPGGAQIVDRLATGLDRSKFDIRVLSRDEAKHQLDTGRVYGSLLIPPSFSSKLRDFATSAVSPARPDKPSITVSTNPRAGTLGASIAGQTLNSAMGTANGIAAQRVMAEVTAQTGGAPLPGATQAGLSSPIEIQSVVYNPLPNGTGNGLSAFYYALLLLLAGFTGSIVVSTLVDALLGYVPAEFGPVYRFAEQVRISRFQTLLLKWAMMVLLGLLTSAVYLAIANGLGMPIDLSWELWAYGVFAIAAVGITSSSLLSVLGTAGMLVSMLVFVIFGLPSAGATVPLEATPPLFRWLAEFEPMHQVFLGTRSLLYFGGRGDAGLSQALTMTSAGLVIGLLLGGIVTHLYDRKGFHRIPGAVEFAIAQDHQAQHQARRGKSTQPPDSPVEPETPAEPESPTNLKAQARKRNSDVPGTSPTRYLY
>NZ_CP016396.1|WP_011726378.1|1933267_1933993_+|pirin-family-protein
MSAGFEIRRAATRAVTTTPWLTSRHSFSFGDHYDPDNTHFGLLLVNNDDIVSPGTGFDTHPHRDMEIVTWVLAGALAHQDSTGNRGVVYPGLAQRMSAGRGILHSERNDSPSLPVHFVQMWVIPDEAGIDPSYQQHEIDDTALGGGLVTIASGIRGHDAAISLHNRNAALHGARLPAAAAVDLPAAPYLHVFLARGRADIEDVGELHPGDAVRFTDTDGRRVTGLEPSELLIWEMHARLGG
>NZ_CP016396.1|WP_011726377.1|1932351_1933242_+|MarR-family-transcriptional-regulator
MAKSIGETPRRSGVKSPPTARVMDVLAAVADSPGGLTSAELAKGCAISSSTCALVLAELERRAWVTRRDDRRYVLGSGLFGLVHGLREQFPLLDRGRDALRLLHERLGAGCSMSKIGARHLTTVDSVGHGTDGEHAVGQRFPIDPPFGLVAMAWRDDDAVQAWLRRVTPRLTRTEIAQHQRVLADIRARGYGAWRFDDTHRSLHNRLAEALASLEPTAQVARRLTTLMTMVTLRSVTDVLETELPTTEFVVLPIFGHDGQPEYQIEIHLGHSAGLTLPELDDALEQARRLLTAPVR
>NZ_CP016396.1|WP_011726386.1|1943074_1944688_-|virulence-factor-Mce-family-protein
MSTIFDIRNIRLPKLSRTSVILGALVIVLALVVGYVGWRLYEKLTNNTVVAYFPAANALYPGDKVQIMGLRVGAIDKIEPSGDKMKVTFHYQNKYRVPANASAVILNPTLVASRAIQLEPPYKGGPVLADNAVIPEERTQVPVEWDQLRNSITNIISKLGPTAEQPKGPFGEVIESFADGLAGKGKQFNTTLTNLSRALTALNEGRGDFFAVVRSLALFVNALHQDDQQFVALNQNLADFTTRLAHSDGDLANAIEQFDSLLTTVRPWLDKNRGVLTYDVKNLETATNALLQPDPLNGLETALHVLPTAAANINQIYHPSHGSVVAIPSITNFANPMQFICSAIQAGSRLGYQESAELCAQYLAPILDAIKFNYPPFGLNLFSTAETLPKEVAYSEPRLQPPNGYKDTTVPGIWVPDTPTSHRNTQPGWIVAPGMQGQQVGPITAGLMTPDSLEELMGGPNIAPVQSNLQTPPGPPNAYDENPILPPMGLNAPVPIPPPPPGPGVAPGPVAPTPAPVSAPAPNAGGPAAPADFGGGQ
>NZ_CP016396.1|WP_065370890.1|1944684_1946250_-|MCE-family-protein
MRTLEPPNRVRIGLMGIVVTVLVIGVGQSFTSVPMLFAKPSYYGQFTDSGGINTGDKVRIAGMDVGKVEGLKIDGDHIVVKFSIGTNTIGTESRLAIKTDTILGKKILDVEARGSQQLRPGSTLPLGQSTTPYQIYDAFFDVTKAAQGWDIETVKQSLHVLSQTIDQTYPHLSPALDGVAKFSDTIGKRDEQVKHLLAQANQVASVLGDRSDQIDRLLVNTKTLLAAFNERGQAINALLGNIAAFSEQVKGLINDNPNLNHVLEQLRTVSDILVQRKDDLANGLTEVGKFLPSLNEAIASGPFFKVVLHNLALYQISQPWVDAAFKKRGIDPEDFWRSAGLPAYRFPDPNGTRFPNGAPPPAPPVLEGTPDHPGPAVPPGSPCSYTPAADGLPRPDNPLPCAGAVTGPFGGPGFPAPVDVMTSPPNPAGLPPTPGIPIAGRPGDAPPDVPGTRVPLPTQAPPGARTENLAPAGPVPPPSTFAPGLPPGPPAPPGPGNQLPAPFINPGGTGGSGAAGGGSQN
>NZ_CP016396.1|WP_003874130.1|1946246_1947287_-|virulence-factor-Mce-family-protein
MKITGTLVRLSIFSVVLLIFTVMIIVVFGQMRFDRTNGYSAEFSNISGLRAGQFVRASGVEVGKVSSVQLVDGGKRARVEFNVDRSVPLYQSTTAQIRYLDLIGNRYLELKRGQGEGADKVLPPGGFIPLSRTQPALDLDALIGGFKPLFRALDPQKVNTIATALVTVFQGQGGTINDILDQTAQLTSQLGERDQAIGEVIKNLNTVLDTTVRHRQQFDQTINNLEVLITGLKDHGDQLAGGTAHISNAAGTVADLLAEDRSLLHKTLNYLDAVQQPLIDQQDQLQDYLKKVPTALNMIGRAIGSYGDFVNFYACDITLKINGLQAGGPVRTVRLFQQPTGRCTPQ
>NZ_CP016396.1|WP_065370891.1|1947283_1948588_-|MCE-family-protein
MARPVQTNAPRTPPYKLAGLAILVVGALALALIYGQFRGNFTPKTSLTMLASRAGLVMDPGSKVTYNGVEIGRVGTISETVRDGKPAAKFTLEVYPRYLKLIPSNVNADIKATTVFGGKYVSLTTPAHPSPQKITPHTIIDARSVTTEINTLFQTITSIAEKVDPVKLNLTLSAAAQSLSGLGEKFGQSVVNANALLDDVNPRMPQARKDIQGLAALGDTYADASPDLFDFLNNAVITSRTINAQQKDLDQALLSAAGFGNTGAELFTKGGPYLARGAQDLIPTAQLLDTYSPEIYCLMRNEHDALPATGAAEGGFNGYSLNMNTEALSGLGLIANPVSAVPVIASMVGGIVGVVGGAPNPYIYPENLPRVNARGGPGGAPGCWQPITHDLWPAPELVIDSGNSLAPYNHLDTGSPYAIEYVWGRQVGDNTINP
>NZ_CP016396.1|WP_003874163.1|1948593_1949463_-|ABC-transporter-permease
MSTAAVFRSRFPRAAENLNRYGLAAARGLDDVGQMAWFGGVALAHIPHALSHYRKETLRLIAQIGMGTGAMAVIGGTVAIVGFVTLSGSSLVAIQGFASLGNIGVEAFTGFFAALINVRIAAPVVTGIAMAATVGAGATAELGAMRISEEIDALEVMGIKSISFLATTRIMAGLVVIIPLYALAMIMSFLSPQITTTVLYGQSNGTYEHYFRTFLRPDDVFWSFLEAIIITAVVMITHCFYGYNAGGGPVGVGEAVGRSMRFSLVSVQVVVLAAALALYGVNPNFALTV
>NZ_CP016396.1|WP_003874164.1|1949464_1950280_-|ABC-transporter-permease
MTSTSTSRRGPYLVGYLRDQLETPLTLVGGFFRMCVLTGKALFRWPFQWREFVLQCWFIMRVAFLPTIMVSIPLTVLLIFTLNVLLAQFGAADLSGAGAAIGAVTQLGPLTTVLVVAGAGSTAICADLGARTIREEIDAMEVLGIDPIHRLVVPRVIAATLVATLLNGLVITVGLVGGYLFGVYLQNVSGGAYLATLTTITGLPEVVIATVKAAVFGLIAGLVGCFRGLTVRGGSKGLGTAVNETVVLCVVALYAVNVVLTTIGVRFGTGH
>NZ_CP016396.1|WP_003874167.1|1953031_1953472_-|SRPBCC-family-protein
MPVLSKTVEVNTDAAAIMAIVADFERYPEWSDGVTGCWVLARYDDGRPSQLRLDAAYQGFEGVYIQAVYYPGPNQIQTVMQQGELFKKQEQLFSVVEMGASSLLTVDIDVEPSMPVPAPMVKSMLNNVLDHLADNLKQRAEQLAAN
>NZ_CP016396.1|WP_023879447.1|1953515_1954001_-|acyl-CoA-thioesterase
MASAPVVPPAPEGLTSNDFPVLWPVGTRWADNDMFGHLNNAVYYQLFDTAINGWINTSTGLDPLTTPALGIVAESGCRYLSELHFPEGLQVGLAVTRLGRSSVTYRLGVFRSAAPGSAEPITALGHWVHVYVDRDTRKPVPIPDPIRTLLAGAAVGDAAPK
>NZ_CP016396.1|WP_065371192.1|1954015_1955128_+|alcohol-dehydrogenase-catalytic-domain-containing-protein
MSGIRGAVLQRIGAPRPYARSRPISITDVELAPPGRDEVLVRIEAAGICHSDLSVVDGNRVRPVPMLLGHEAAGIVERVGPGVADLAVGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLSRAGRPVYHHLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGGGAVLNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAARRLGAHQAYTPQQAVEARVKAAVVIEAVGHPAALQTAIDLTAPGGRTITVGLPPPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRFVELWRAGRLPVESLVSSTIRLEDINEGMDHLADGTAVRQLIRFDA
>NZ_CP016396.1|WP_009979740.1|1955221_1955470_+|hypothetical-protein
MAQSALKHGYSIEEISHAYDNYVFEGTIDDGADPPKILTIGPDSAANLLELVGGRRPNGDHLIWHAMRCRRQYLILVPDCGM

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Crispr_ID: NZ_CP016396_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016396_3

3360027-3360117

Orphan

Consensus_repeat	Method
CGCGCCGCGCGGCGGCGCGCATCGTCGCCGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016396_3

>merge|NZ_CP016396|3|3360027-3360117|CRISPRCasFinder
CGCGCCGCGCGGCGGCGCGCATCGTCGCCGGGCGGGGTCAGATTGCCCGGCTCCTCCTCGCGCCGCGCGGCGGCGCGCATCGTCGCCGGGC

>NZ_CP016396|3|3|3360027-3360117|CRISPRCasFinder
CGCGCCGCGCGGCGGCGCGCATCGTCGCCGGGC	GGGGTCAGATTGCCCGGCTCCTCCT
CGCGCCGCGCGGCGGCGCGCATCGTCGCCGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016396.1\|WP_023879675.1\|3350140_3353368_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|237263
NZ_CP016396.1\|WP_009978004.1\|3361849_3363526_+\|ribonuclease-J	unknown	unknown	gnl\|CDD\|223668
NZ_CP016396.1\|WP_031347706.1\|3366023_3368348_+\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|224588
NZ_CP016396.1\|WP_009978011.1\|3355857_3356598_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366780
NZ_CP016396.1\|WP_023861132.1\|3363634_3364507_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|272862
NZ_CP016396.1\|WP_009978016.1\|3353826_3354606_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235975
NZ_CP016396.1\|WP_065371038.1\|3348620_3350144_+\|acyl--CoA-ligase	unknown	unknown	gnl\|CDD\|341286
NZ_CP016396.1\|WP_003875200.1\|3369042_3369615_+\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|223632
NZ_CP016396.1\|WP_003875184.1\|3353380_3353707_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016396.1\|WP_009978001.1\|3365342_3365657_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NZ_CP016396.1\|WP_009978008.1\|3357437_3357983_+\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NZ_CP016396.1\|WP_065371039.1\|3360927_3361830_+\|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl\|CDD\|235107
NZ_CP016396.1\|WP_003875199.1\|3368434_3368977_-\|amino-acid-N-acetyltransferase	unknown	unknown	gnl\|CDD\|236132
NZ_CP016396.1\|WP_009978009.1\|3356640_3357441_+\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|234984
NZ_CP016396.1\|WP_029248547.1\|3358817_3360026_+\|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225755
NZ_CP016396.1\|WP_003875201.1\|3369742_3370069_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP016396.1\|WP_003878641.1\|3360131_3360884_+\|FAD-dependent-thymidylate-synthase	unknown	unknown	gnl\|CDD\|234847
NZ_CP016396.1\|WP_009978002.1\|3364512_3365343_-\|mycofactocin-coupled-SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|274889
NZ_CP016396.1\|WP_009978007.1\|3358052_3358787_+\|cell-division-protein-DivIVA	unknown	unknown	gnl\|CDD\|377456
NZ_CP016396.1\|WP_009978015.1\|3354666_3355869_+\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340817

Protein	Function_ID	Function_description	E-value
NZ_CP016396.1\|WP_023879675.1\|3350140_3353368_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|237263	PRK12999, PRK12999, pyruvate carboxylase; Reviewed.	1.18179e-161
NZ_CP016396.1\|WP_009978004.1\|3361849_3363526_+\|ribonuclease-J	gnl\|CDD\|223668	COG0595, COG0595, mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair].	0
NZ_CP016396.1\|WP_031347706.1\|3366023_3368348_+\|DNA-translocase-FtsK	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	2.25235e-177
NZ_CP016396.1\|WP_009978011.1\|3355857_3356598_-\|hypothetical-protein	gnl\|CDD\|366780	pfam01738, DLH, Dienelactone hydrolase family.	1.47209e-54
NZ_CP016396.1\|WP_023861132.1\|3363634_3364507_-\|SAM-dependent-methyltransferase	gnl\|CDD\|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	4.6686e-76
NZ_CP016396.1\|WP_009978016.1\|3353826_3354606_+\|SDR-family-oxidoreductase	gnl\|CDD\|235975	PRK07231, FabG-like, SDR family oxidoreductase.	2.18285e-123
NZ_CP016396.1\|WP_065371038.1\|3348620_3350144_+\|acyl--CoA-ligase	gnl\|CDD\|341286	cd17631, FACL_FadD13-like, fatty acyl-CoA synthetase, including FadD13. This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.	2.21662e-131
NZ_CP016396.1\|WP_003875200.1\|3369042_3369615_+\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl\|CDD\|223632	COG0558, PgsA, Phosphatidylglycerophosphate synthase [Lipid metabolism].	9.40248e-33
NZ_CP016396.1\|WP_009978001.1\|3365342_3365657_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	1.24931e-24
NZ_CP016396.1\|WP_009978008.1\|3357437_3357983_+\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	8.69567e-63
NZ_CP016396.1\|WP_065371039.1\|3360927_3361830_+\|4-hydroxy-tetrahydrodipicolinate-synthase	gnl\|CDD\|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	2.53771e-146
NZ_CP016396.1\|WP_003875199.1\|3368434_3368977_-\|amino-acid-N-acetyltransferase	gnl\|CDD\|236132	PRK07922, PRK07922, amino-acid N-acetyltransferase.	6.98687e-116
NZ_CP016396.1\|WP_009978009.1\|3356640_3357441_+\|thymidylate-synthase	gnl\|CDD\|234984	PRK01827, thyA, thymidylate synthase; Reviewed.	0
NZ_CP016396.1\|WP_003878641.1\|3360131_3360884_+\|FAD-dependent-thymidylate-synthase	gnl\|CDD\|234847	PRK00847, thyX, FAD-dependent thymidylate synthase; Reviewed.	2.15343e-100
NZ_CP016396.1\|WP_003875201.1\|3369742_3370069_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.54828e-11
NZ_CP016396.1\|WP_029248547.1\|3358817_3360026_+\|winged-helix-turn-helix-domain-containing-protein	gnl\|CDD\|225755	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown].	5.93108e-106
NZ_CP016396.1\|WP_009978002.1\|3364512_3365343_-\|mycofactocin-coupled-SDR-family-oxidoreductase	gnl\|CDD\|274889	TIGR03971, short-chain_dehydrogenase/reductase_SDR, SDR family mycofactocin-dependent oxidoreductase. Members of this protein subfamily are putative oxidoreductases belonging to the larger SDR family. All members occur in genomes that encode a cassette for the biosynthesis of mycofactocin, a proposed electron carrier of a novel redox pool. Characterized members of this family are described as NDMA-dependent, meaning that a blue aniline dye serving as an artificial electron acceptor is required for members of this family to cycle in vitro, since the bound NAD residue is not exchangeable. See EC 1.1.99.36. [Unknown function, Enzymes of unknown specificity].	6.80069e-144
NZ_CP016396.1\|WP_009978007.1\|3358052_3358787_+\|cell-division-protein-DivIVA	gnl\|CDD\|377456	pfam05103, DivIVA, DivIVA protein. The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype. These proteins appear to contain coiled-coils.	5.73787e-06
NZ_CP016396.1\|WP_009978015.1\|3354666_3355869_+\|glycosyltransferase-family-1-protein	gnl\|CDD\|340817	cd03784, GT1_Gtf-like, UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.	6.73612e-57

>NZ_CP016396.1|WP_029248547.1|3358817_3360026_+|winged-helix-turn-helix-domain-containing-protein
MSTRRLSVAQARRIAVAAQGFTEPRPAGAVTRAHLNRLISKIQVLQLDSVSVTVRAHYAPVFSRLGPYDREVLDRAAWGPRSSRLLVEYWAHEAALMAVEDWPLLRWRMRQYRHGRWGTHIVQANPRLADAVVAAVAELGPSTAGQIEAHLAAEPRRRKGAWWNRSDTKWVAEALFAAGVLTTATRVGFARHYDLVERVLPADVLARRVDDDEAIRELTLRAAGALGVGTEADIRDYFRLSAAQVKPAIAELVAAGDLERVEVAGWPAPAYLRAGRAVPRTDRGTALLCPFDPLIFFRPRVERLFEFHYRIEIYTPAAKRRYGYYVWPLLMDGRLAARVDLKADRAEGTLRVLGAFAEPQAPRPRVAAALAGELWSMASWLGLGGLSVADRGDLAPALRAVA
>NZ_CP016396.1|WP_009978007.1|3358052_3358787_+|cell-division-protein-DivIVA
MITEPVKTFSRKFMGYDTTAVDAHIEMLTAKQQLLIDDVESLRARLQESNEQTAALRKEVAALTDTSPAPHAVQQRMAKMLARAVDEVAEMQAEARAEADALIAAAEAEAQAAERKRDEVLADMAAQQEALEAEYRETKEKLDAELADMRAEAQAAIDEARRAAERECEQLLGDAKQGADHYRDTARRAVEEASAQRIKILEQLMSVYRELEDVPAALQAAYDEQQGSADDGVLAAVDGKVRAG
>NZ_CP016396.1|WP_009978008.1|3357437_3357983_+|dihydrofolate-reductase
MTRAEVGLVWAQSTSGVIGRGGDIPWNVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRPLPGRRNVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEVTEIEIDLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRRDPRSSVRGCSPSRPS
>NZ_CP016396.1|WP_009978009.1|3356640_3357441_+|thymidylate-synthase
MPIPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFPLITTKKVHLKSVVYELLWFLRGDSNVDWLHRHGVTIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIPRMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELVLAHRDSIFDYTYDDVVVHNYDPHPAIKAPVAV
>NZ_CP016396.1|WP_009978011.1|3355857_3356598_-|hypothetical-protein
MPKITDSISTADGTCPVRLFLPDGSGPWPGVVMYPDAGGVRDTFDQMAAELAGFGYAVLLPDVYYRSGEWAPFDMATVFADQQERNRLFAMIGSVTPDRMATDAAAFFDYLAARPEVSGDRFGVCGYCMGGRTSLIVAGRLPDRVAAAASFHGGGLVTDSDDSPHLLADRMSATVYVGGAQDDASFTTDHAEQLDKALTAAGVRHTIEWYSAAHGFAVPDNAPYDPAAAERHWDAMRDVFAAALPR
>NZ_CP016396.1|WP_009978015.1|3354666_3355869_+|glycosyltransferase-family-1-protein
MRVLLSAYDSRGGVQPLAALAVQLRALGVDARVSAPPDAEFAELLARAGVPLVAFGDSLRAMKTAATTPSEEQLRRQLDGLIAAQFDAAAAARECDALVVAGFPPAAAAARSAAEKQGAHYVYVSYQPTILPSPHYPPPGYADAAIDNRLLWQLDGRYMQALFGETLNARRAAIGLPPLDDLRGYALTERPWLATDPTLDPWRPPGDLDVVQTGAWLLADDRRLPAELDAFLDAGAPPVYVGFGSMPMRACRDVARVAIEAVRAQRRRVVVSRGWAGLGPIDDGEDCLVVGEVNHQALFGRVAAVVHHGGVGTLTAAALAGAPQVVVPQGADQPYWAARVAELGIGAAHDGPAPTVESLSAVLGTALTERTRARAGAVAATIRTDGAARAARLLVARLAG
>NZ_CP016396.1|WP_009978016.1|3353826_3354606_+|SDR-family-oxidoreductase
MTSQDLTGRTAIITGASRGIGLAIAQQLAAAGANVVLTARKQEAADEAAAQVGPQALGVGAHAVDEDAARQCVQLTLERFGSVDILVNNAGTNPAYGPLIEQDHARFAKIFDVNLWAPLLWTSLAVKSWMGEHGGSIVNTASIGGLHQSPAMGMYNATKAALIHVTKQLALELSPRVRVNAIAPGVVRTRLAEALWKDHEDPLSSSIALGRIGEPIDVAAAVAFLVSEAASWITGETLVIDGGTVLGAAQGFRPAPTPS
>NZ_CP016396.1|WP_003875184.1|3353380_3353707_-|hypothetical-protein
MKPLVVAAAAAAAIAAAPAAAADVIVAGPAGPAAPTHITFKDDPGGGGCDANGNCGSGGQDQGPGGGPGGQGCVPGVGCGSGGQFAGPGGVPGGQGCLPGVGCGSGHA
>NZ_CP016396.1|WP_023879675.1|3350140_3353368_+|ATP-grasp-domain-containing-protein
MTASLLVANRGEIALRIIRTATELGMRTVAVYAADDAHSPHVHAADEAMPLPGSGPPAYLNQAALLAVAENTGATLIHPGYGFLSENAEFAEACAAARRTFVGPDARVLELLGNKTAARRAAIAAEVPTLAATDGPSGVEDIEAFFAAHPGGIMIKALAGGGGRGMRKVHNAAQIAGAYQRCAAEARLGFGDPALFAEALLGDARHIEVQVVAAPAGHQTHALAVGDRDCSMQRRYQKLIEIAPAQGLSEELRRALHQAAVRLCARVGLRGLATVEFLVSGERFVFLEVNPRIQVEHTVTEQTTGLDLVAVQLAIAGGESYYRLGLPAGIASDGTEVIGEPAAQRGIAIQLRVNAETFGADFSVLPSAGTLTAFCPPSGRGVRVDTYGRPGLVVSPQYDSLLAKVIVAVHGSSWRAAMRKADTALSEFGVEGVATNIGFLRRLLAEQRLETGWVNTDFVDDKLPELAAAALTHQPGPQPGAVELYPGEDALRAQLAGTVVEVAPEGADYPAGAQLVVLEAMKMQHVLAAPDALRTVRVLVTPGQVVGTGDPLLVFTRTTGGDDGESVTAATDLDLTRADLDEVIERHARTLDEGRPDAVAKRHRQGRRTARENIDDLVDPGSFVEYGALAIAAQRSRRSEEDLIANTPADGLVAGLATIGADRFGRAAAQAVVASYDYTVLAGTQGMRNHAKTDRVFDLAARKRLPVVLFAEGGGGRPGDTDVGGAAGLDVPTFRMLAGLRGRVPLVSVVSGRCFAGNAALAGVCDVIIATPDANIGMGGPAMIEGGGLGVYPPEAIGPIAVQRRNGVVGLVARDEAHAVSLAKQYLSYFQGRLDRWQAPDPRVARHVVPQNRLRAYDVHRAIEAIVDVGSVLELRPDYGVGIVTALVRVEGVPYGLIANSTHHLGGAIDAEAADKAGDFLALCESFGLPVISLCDTPGFMVGPDAETQAAVRRFGRMFVLGARLTVPLGMIILRKGYGLGAMAMAGGSFRAPQFTVAWPTGEIGGMGLEGAVRLGYRKELAAVTDPAERQNLFDRLVAAAYQHGKALRAATTFELDDVIDPAASRAWITRLSGG
>NZ_CP016396.1|WP_065371038.1|3348620_3350144_+|acyl--CoA-ligase
MIEIAREHNPFPTTGVSRGRDGIPRYDELPATLVDMLVDQVDARPDGEAVVELGGGRLTYRQLWDRAVRVAGGLRADGLRRGDRVAVRYPAGIDWVLAFWGTVLAGGVAVAVNTRSAQPEVDFVLSDSGARLQLAPGDPLPDGKPYVTKQLGAADTAALFYTSGTTGHPKGVPTTHEAFLTNTENAIRCLQQPRDLGEDMRTLISVPLFHVTGCNSQLLAAARLGGASVILPALDLDTLLNAVVAERVSVMVTVPAIYALLLRHKDFAGNDVSRVRWVGYGGAPIAPSLVRTVKDTFPHATVFNGYGMTETASLMTVLPDREAVEHADSVGYAVPSVDLGLIPFGDNEPGVGELVTRGGNVTAGYWNRPQATASTFAGGWLHTGDVVRVDDAGRVHIIDRLKDIINRGGENVSSVEVEAVLLGAPGVADACVLGVPDDVMGEKVGAVLFGDDDIDVPAVLEHCRGRLADFKVPQYVTVADGPLPRNAGGKLLKARLRDQVRWGDPLR
>NZ_CP016396.1|WP_003878641.1|3360131_3360884_+|FAD-dependent-thymidylate-synthase
MAEIAPLRVQLIAKTDFLAPPDVPWSTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYIKHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPENDSRVVVPPGLDDDPELQQILAAAADASRATYTELLARLEAKFADQPSAVLRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRRLADVAPAVFADFEIATLADGTEVATSPLATEA
>NZ_CP016396.1|WP_065371039.1|3360927_3361830_+|4-hydroxy-tetrahydrodipicolinate-synthase
MSTVGFDAPARLGTVLTAMVTPFASDGSLDTAAAARLANHLVDSGCDGLVVSGTTGESPTTTDDEKRELLRVVLEAVGDRARVIAGAGTYDTAHSVRLAKACAAEGAHGLLVVTPYYSKPPQRGLIAHFTAVANATELPVLLYDIPGRSVVPIESSTIRALASHPNIVGVKDAKADLHAGGQIIAETGLAYYSGDDALNLPWLAMGATGFISVISHVAANQLRELLSAFTSGDIATARKINATVAPLCDAMARLGGVTMSKAGLRLQGIDVGDPRLPQLPATPEQIEALSADMRAASVLR
>NZ_CP016396.1|WP_009978004.1|3361849_3363526_+|ribonuclease-J
MDVDLAPPGPLAAGGLRVTALGGISEIGRNMTVFEHLGRLLIIDCGVMFPTHDEPGVDLILPDLRHIEDRLDDIEALVLTHAHEDHIGGIPYLLKLRPDIPVVGSKFTLALVAAKCREHRLKPVFVEVSEGHKSTHGVFECEYFAVNHSIPDALAIAVHTGAGTVLHTGDIKLDQLPLDGRPTDLPGMSRLGDAGVDLFLCDSTNAELPGVGPSESEVGPTLHRLIRGAEGRVIVACFASNVDRVQQIIDAAVALGRRVSFVGRSMVRNMGIARELGFLRVADADVIDIGAAELMPPERVVLITTGTQGEPMSALSRMSRGEHRSITLTAGDLVVLASSLIPGNEEAVYGVIDELAKIGARVVTNAQARVHVSGHVYAGELLFLYNGVRPRHVMPVHGTWRMLRANSKLAARTGVPEESILLAENGVSVDLVAGRASISGAVPVGKMFVDGLVDGDVGDITLGERLILSSGFVAVTVVVQRGTGRPVAPPHLHSRGFSEDPKALEPAVRRVEEELEALVAENITDPSRIAQGVRRTVGKWVGETYRRQPMIVPTVIEV
>NZ_CP016396.1|WP_023861132.1|3363634_3364507_-|SAM-dependent-methyltransferase
MARNPVAQTAFGPMVLAAVEQNEPPGRRLVDDDFAELFLPAPLRWLVGATRFAPVRHLMIRGSEFTGPGLWANLACRKRFIADKLKESLDDINAVVILGAGLDTRAYLLTRRVRIPVFEVDLPVNVARKFKTVRRVLGELPLSVRLVALDLEHDDLLTALAEHGYRTDYRVFFICEGVTQYLSEATVRRTLDGLRAAAPGSRLVFTYVRSDFIDGTNRYGTRTLYRNVRQRRQLWHFGLQPGEVADFLAEYGWRLVEQAGPDELMQRYVVPTGRKLKASQLEWSAYAEKT
>NZ_CP016396.1|WP_009978002.1|3364512_3365343_-|mycofactocin-coupled-SDR-family-oxidoreductase
MPRSSEGPLTGKVAFITGAARGQGRAHAVRLAADGADIIAVDLCDQIASVPYPLATPEELAATVKLVEDIGSRIVARQADVRDRESLSAALQAGLDEFGRLDIVVANAGIAPMSAGDDGWHDVIDVNLTGVYHTIKVAIPALVKQGTGGSIVLISSSAGLAGVGSADPGSVGYVAAKHGVVGLMRVYANLLAGQMIRVNSIHPSGVETPMINNEFTREWLAKMAAATDTPGAMGNAMPVEVLAPEDVANAVAWLVSDQARYITGVTLPVDAGFLNK
>NZ_CP016396.1|WP_009978001.1|3365342_3365657_-|antibiotic-biosynthesis-monooxygenase
MPVVVVATMTVKPESVDTVRDILTRAVEEVHDEPGCQLYSLHQSGETFVFVEQWADEEALKTHSTAPAIGKMFSAAGEHLDGAPDIKMLQPVPAGDPGKGQLRP
>NZ_CP016396.1|WP_031347706.1|3366023_3368348_+|DNA-translocase-FtsK
MAARGTGGAARSIGRARDIDPGHRRDGIALLLLGFSVVVAASSWFHAAGPVGAWVDTALRTFIGAGVLALPVVTAAVAVTLMRTEPDPDVRPRLILGAGLIALSVLGLRHLWSGSPGDPDARRRAAGFIGFAIGGPLSDGLTPWIAAPLLFIGFMFGLLLLTGTTIRELPVVMRNLFHTRFVEDYTDEDYTDADYTDGDYGDEPYDYAGEFDDATAQPEPEPAAWAPDDDAQAALQDDIPTVPEPAVKTGRGRKRGRAADNSDTIELDRVVEGPYVLPSLSLLVAGDPPKKRSAANNVMADAITEVLNQFKVDAAVTGCTRGPTVTRYEVELGPGVKVEKITALQKNIAYAVATESVRMLAPIPGKSAVGIEVPNTDREMVRLADVLTAPSTRRDHHPLVIGLGKDIEGDFISANLAKMPHLLVAGSTGSGKSSFVNSMLISLLARATPEEVRMILIDPKMVELTPYEGIPHLITPIITQPKKAAAALAWLVEEMEQRYQDMQASRVRHIDDFNAKVRSGEITAPLGSQREYRPYPYVVAIVDELADLMMTAPRDVEDAIVRITQKARAAGIHLVLATQRPSVDVVTGLIKTNVPSRLAFATSSLTDSRVILDQAGAEKLIGMGDGLFLPMGASKPIRLQGAFITDEEIQAVVAACKDQAEPEYTEGVTAVKTSSERADVDPDIGDDMDVFLQAVELVVSSQFGSTSMLQRKLRVGFAKAGRLMDLMETRGIVGPSEGSKAREVLVKPDELAGTLALIRGSGAGSADADGGDPD
>NZ_CP016396.1|WP_003875199.1|3368434_3368977_-|amino-acid-N-acetyltransferase
MPILLAVTESPQRYRPLVRRARTSDVPAIKELVDTYAGKILLEKNLVTLYEAVQEFWVAELPDSPGRVVGCGALHVLWSDLGEIRTVAVNPAMTGHGIGHAIVDRLLQVARELELKRLFVLTFETEFFGKHGFTEIEGTPVTAEVFEEMCRSYDIGVAEFLDLSYVKPNILGNSRMLLVL
>NZ_CP016396.1|WP_003875200.1|3369042_3369615_+|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MVGRANIANLANTLTLLRLVLVPVFLLALFAGDGHETGFRILAFLIFAFACITDRLDGLLARNYGMATEFGAFVDPIADKTLVGSALIGLSMLGELPWWITVLILAREFGVTVLRLAVIRRGVIPASWGGKLKTVVQVFAIGLFVLPWAGTPGPFRVGAAVVMGAAIVLTVITGIDYVVSTVREVRRTAA
>NZ_CP016396.1|WP_003875201.1|3369742_3370069_+|helix-turn-helix-transcriptional-regulator
MPPLVREVIGDVLREARTTQGRTLREVSDTARVSLGYLSEVERGRKEPSSELLNAICDALDVPLSSVLTDAGERMASEERAAVAAPAGPSIDASTKVVIPPVASLALA

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Crispr_ID: NZ_CP016396_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016396_4

4494778-4494869

Orphan

Consensus_repeat	Method
TTCCTCGCTGCGCTTGCGTGCCTTCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016396_4

>merge|NZ_CP016396|4|4494778-4494869|CRISPRCasFinder
TTCCTCGCTGCGCTTGCGTGCCTTCTGGGCCAGATAGGCTGCCCGCTCGGCGGCCTCGTCGGCCAATTCCTCGCCGCGCTTGCGTGCCTTCT

>NZ_CP016396|4|4|4494778-4494869|CRISPRCasFinder
TTCCTCGCTGCGCTTGCGTGCCTTCT	GGGCCAGATAGGCTGCCCGCTCGGCGGCCTCGTCGGCCAA
TTCCTCGCCGCGCTTGCGTGCCTTCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016396.1\|WP_009976720.1\|4489435_4490953_+\|carboxylesterase/lipase-family-protein	unknown	unknown	gnl\|CDD\|225181
NZ_CP016396.1\|WP_003876749.1\|4493960_4494539_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226648
NZ_CP016396.1\|WP_009976725.1\|4493540_4493930_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|314732
NZ_CP016396.1\|WP_031354786.1\|4496215_4497016_+\|transporter	unknown	unknown	gnl\|CDD\|366932
NZ_CP016396.1\|WP_009976733.1\|4499871_4500816_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP016396.1\|WP_003878038.1\|4497029_4497380_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379266
NZ_CP016396.1\|WP_009976731.1\|4497548_4498481_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236600
NZ_CP016396.1\|WP_003876752.1\|4490971_4492969_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|367273
NZ_CP016396.1\|WP_023884348.1\|4503720_4504008_-\|DUF3349-domain-containing-protein	unknown	unknown	gnl\|CDD\|371747
NZ_CP016396.1\|WP_023884346.1\|4484825_4485908_+\|dihydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|226326
NZ_CP016396.1\|WP_023884347.1\|4492965_4493460_+\|gluconokinase	unknown	unknown	gnl\|CDD\|225804
NZ_CP016396.1\|WP_009976717.1\|4486632_4487262_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP016396.1\|WP_003876738.1\|4502726_4503695_+\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|132846
NZ_CP016396.1\|WP_009976718.1\|4487355_4488579_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP016396.1\|WP_155251422.1\|4495655_4496216_+\|pyrazinamidase-PncA	unknown	unknown	gnl\|CDD\|238493
NZ_CP016396.1\|WP_009976716.1\|4486016_4486625_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016396.1\|WP_009976719.1\|4488676_4489342_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016396.1\|WP_009976732.1\|4498546_4499875_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP016396.1\|WP_029248479.1\|4501647_4502733_+\|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	unknown	unknown	gnl\|CDD\|236947
NZ_CP016396.1\|WP_003876741.1\|4500802_4501645_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472

Protein	Function_ID	Function_description	E-value
NZ_CP016396.1\|WP_009976720.1\|4489435_4490953_+\|carboxylesterase/lipase-family-protein	gnl\|CDD\|225181	COG2272, PnbA, Carboxylesterase type B [Lipid metabolism].	0
NZ_CP016396.1\|WP_003876749.1\|4493960_4494539_+\|AAA-family-ATPase	gnl\|CDD\|226648	COG4185, COG4185, Uncharacterized protein conserved in bacteria [Function unknown].	9.75582e-70
NZ_CP016396.1\|WP_009976725.1\|4493540_4493930_+\|hypothetical-protein	gnl\|CDD\|314732	pfam11903, ParD_like, ParD-like antitoxin of type II bacterial toxin-antitoxin system. ParD-like antitoxin is a family of archaeal and bacterial proteins of a type II bacterial toxin-antitoxin system. Many of the cognate toxins for these molecules fall into family ParE-like_toxin, pfam15781. Gene-pairs are expressed from the same operon, the toxin of the pair being expressed first, eg, for UniProtKB:Q3AQ93 and UniProtKB:Q3AQ94.	1.43668e-14
NZ_CP016396.1\|WP_031354786.1\|4496215_4497016_+\|transporter	gnl\|CDD\|366932	pfam02136, NTF2, Nuclear transport factor 2 (NTF2) domain. This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.	3.55011e-08
NZ_CP016396.1\|WP_009976733.1\|4499871_4500816_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	9.86745e-95
NZ_CP016396.1\|WP_003878038.1\|4497029_4497380_-\|hypothetical-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	5.93423e-10
NZ_CP016396.1\|WP_009976731.1\|4497548_4498481_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236600	PRK09636, PRK09636, RNA polymerase sigma factor SigJ; Provisional.	1.30023e-58
NZ_CP016396.1\|WP_003876752.1\|4490971_4492969_+\|phosphotransferase	gnl\|CDD\|367273	pfam02958, EcKinase, Ecdysteroid kinase. This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates.	2.61926e-23
NZ_CP016396.1\|WP_023884348.1\|4503720_4504008_-\|DUF3349-domain-containing-protein	gnl\|CDD\|371747	pfam11829, DUF3349, Protein of unknown function (DUF3349). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 99 to 124 amino acids in length.	1.2494e-23
NZ_CP016396.1\|WP_023884346.1\|4484825_4485908_+\|dihydrodipicolinate-reductase	gnl\|CDD\|226326	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown].	1.91712e-65
NZ_CP016396.1\|WP_023884347.1\|4492965_4493460_+\|gluconokinase	gnl\|CDD\|225804	COG3265, GntK, Gluconate kinase [Carbohydrate transport and metabolism].	1.92464e-67
NZ_CP016396.1\|WP_009976717.1\|4486632_4487262_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.50585e-09
NZ_CP016396.1\|WP_003876738.1\|4502726_4503695_+\|patatin-like-phospholipase-family-protein	gnl\|CDD\|132846	cd07207, Pat_ExoU_VipD_like, ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2. ExoU, a 74-kDa enzyme, is a potent virulence factor of Pseudomonas aeruginosa. One of the pathogenic mechanisms of P. aeruginosa is to induce cytotoxicity by the injection of effector proteins (e.g. ExoU) using the type III secretion (T3S) system. ExoU is homologus to patatin and also has the conserved catalytic residues of mammalian calcium-independent (iPLA2) and cytosolic (cPLA2) PLA2. In vitro, ExoU cytotoxity is blocked by the inhibitor of cytosolic and Ca2-independent phospholipase A2 (cPLA2 and iPLA2) enzymes, suggesting that phospholipase A2 inhibitors may represent a novel mode of treatment for acute P. aeruginosa infections. ExoU requires eukaryotic superoxide dismutase as a cofactor and cleaves phosphatidylcholine and phosphatidylethanolamine in vitro. VipD, a 69-kDa cytosolic protein, belongs to the members of Legionella pneumophila family and is homologus to ExoU from Pseudomonas. Even though VipD shows high sequence similarity with several functional regions of ExoU (e.g. oxyanion hole, active site serine, active site aspartate), it has been shown to have no phospholipase activity. This family includes ExoU from Pseudomonas aeruginosa and VipD of Legionella pneumophila.	3.46279e-64
NZ_CP016396.1\|WP_009976718.1\|4487355_4488579_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	7.36595e-77
NZ_CP016396.1\|WP_155251422.1\|4495655_4496216_+\|pyrazinamidase-PncA	gnl\|CDD\|238493	cd01011, nicotinamidase, Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).	2.51185e-70
NZ_CP016396.1\|WP_009976732.1\|4498546_4499875_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.59528e-75
NZ_CP016396.1\|WP_029248479.1\|4501647_4502733_+\|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	gnl\|CDD\|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	0
NZ_CP016396.1\|WP_003876741.1\|4500802_4501645_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.10088e-86

>NZ_CP016396.1|WP_003876749.1|4493960_4494539_+|AAA-family-ATPase
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSHPSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRGPRVVARLSGGLTVGAVDWPAWAPETLRSRWPV
>NZ_CP016396.1|WP_009976725.1|4493540_4493930_+|hypothetical-protein
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEISAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR
>NZ_CP016396.1|WP_023884347.1|4492965_4493460_+|gluconokinase
MSGSAPVVVMGVSGSGKSTVGVTLARRLRVPFVDADTLHPPANIAKMAAGTPLGDDDHRPWLDEVGEWLAAHRDGGVAACSALKRAYRDRLRAHCPDVAFLHLSGSAALLGPRLAARSGHFMPAALLQSQLDALEPLGPDEAGLTVDAGREVDSIVDVVLRARR
>NZ_CP016396.1|WP_003876752.1|4490971_4492969_+|phosphotransferase
MHAETEQVIERPSDLSASWLAAVIGTGPIADFSVERIGTGQMSECYRIRLRYAQADARGPESVVLKVAATDPVSRQTGLALGLYEREVRFYGDLAPRLGGPIAPCYHAAVDTSTGVFDLLLGDAGPAVVGDEIAGATIEQARLGVVELGRLHGPLLGDISLAQAPWLNRDAPLNQAMIAPLYAGFVERYGDQIAPEHRAVCERLVAAFDGYLAQEPGVRGLVHGDYRLDNMLFGTAGAERALTVVDWQTVSWGPALTDLAYFLGCALPAKDRREHYDALLRAYHEALGPQPPITLADVADGVRRQSFFGVMMAIVSSMLVERTDRGDQMFMTMLRRHCDHVLDTDALATLPAASAPEPLRPSPEDELAHDPTTEPLWSESWYADFADPAQGLGGWFRLGLVANQQTAWVHALVCGPDMPTVAVDAQVPLPPDPWTVRTDTFEITHSAGAPLRSYRVDVRALAQAYADPAALLRGEPGTPVAMTMNLDWHTDGTPYKYAMTTRYEIPCTVTGSVTIGDTAYRIESVAGQRDHSWGVRDWWSMDWIWSALHLDDGTHLHGVNIRIPGAPAFSIGYTQGADGEVTELQTVDSRESFGDNGLPLDATLELNPGEITAQVDVRGQAPVRLVAADGRVSQFPRVWAAVSTGDGRRGVGWLEWNRNLGERIG
>NZ_CP016396.1|WP_009976720.1|4489435_4490953_+|carboxylesterase/lipase-family-protein
MHDRTVRARTATGIVEGFTRDGVHRWRSIPYARPPVGDLRFRAPQPAQPWSGVRHCHGFANCAPQQRRYTLLGLSGLGGRYQPMSEDCLTLNVVTPEAPAEGPLPVMVFIHGGGYFLGSSATPLYDGAALARRGCVYVSVNYRLGALGCVDFSSLSTPEIPLESNLYLRDLVLALQWVRDNIAEFGGDPDNVTIFGESAGACITATLLAVPAAKGLFAQAISESPASGLVRSQEVAAEFANRFANLLGVRRQDAANALMQASAAQLVKTQHRLIDEGMQDRLGAFPIGPVVGDDILPTDPVEAMRRGEAHRVPLIVGTNAEEGRLFTRFLAMLPTNESMVEELLADAEPAVRERITAAYPNYPDRSACIQLGGDFAFGSAAWQIAEAHCAHAPTYLYRYDYAPRTLRWSGFGATHATELLAVFDVYRTRFGALLTAAADRRAALRVSNQVQRRWRAFSRTGVPGEDWPRYTAAERAVLVFDRKSRVEFDPHRHRRMAWDGFSLAR
>NZ_CP016396.1|WP_009976719.1|4488676_4489342_-|hypothetical-protein
MIAASVLVAGCAHTTGGRSEPTPSGAATPSGSAAGPSSSKPPGPSGAPAAGAAMSDVITWIEAGHPADPSRYHTATRDGVATPLGDDIAVSALAGKVSCMTDAKHTGGAVVCLVSLTHPAPPPATAYGQWQGGWVDFDGTSLQVGSARADPGPFVNGNGTELANGDSLAFGEYRCRADQAGLYCVNYARQSAAKLSPAGVEPFGCLRSTPPPDGVGAAFSC
>NZ_CP016396.1|WP_009976718.1|4487355_4488579_+|cytochrome-P450
MSISFETSESRADAELPVLPMPRAAHCPLAPPPEFVDWRQRPGLRRALFQGNPVWVVSRYRDIRAALVDPRLSAKTIPDSIMPTDADNKVPVMFARTDDPEHHRLRRMLTGNFTFRRCESMRPQIQDTVDHYLDRMLDGGAPADLVREFALPVPSLVIALLLGVLPEDLELFQFNTSKGLDQKSSDEEKGKAFGAMYAYIEELVQRKAREPGDDLISRLITEYVATGQLDHATTAMNSVIMMQAGHETTANMISLGTVALLGNPEIYARLGQTDDAAVVANIVEELMRYLSIVHSQVDRVATEDLTIAGQLIRAGEFVVMNLPAGNWDTEFVDNPESFDADRNTRGHLGFGYGVHQCIGANLARVEMQVAFATLARRLPGLRLAVPPEQLKFKDANIYGMKELPVSW
>NZ_CP016396.1|WP_009976717.1|4486632_4487262_-|TetR/AcrR-family-transcriptional-regulator
MTAVEDRPLRSDAARNVERILRAAREVYAELGPDAPVEAVARRAGVGERTLYRRFPAKADLVRAALDQSIAEDLTPVIDSARHAKDPLHGLTRLVEAAISLGAREQNLLAAAHRAGSLTSDISVSLNEALGELVREGQRAGRIRADLVADDLPRLVAMLYSVLSTMDAGSEGWRRYVALVVDAISVDERRPLPPAAALRYASQPNSWPL
>NZ_CP016396.1|WP_009976716.1|4486016_4486625_+|hypothetical-protein
MTKVRTSALGLTATAVLVGATVVGCGGDKNPAASSSAATSTTSAASPSSAAPADYSNLLIKPGDVGPNATADGPPSQNPSGITGVGQVFKNPDGKRTIMDTIAVFPDPATAAQTAANMRDVVGKKVNGPQQPIDIGSNGFMVIGQGSDPANPMEISEAVFVEGRAMVDLESDCVIGNPTPADVLLDLARKQDAAVKAGLPAG
>NZ_CP016396.1|WP_023884346.1|4484825_4485908_+|dihydrodipicolinate-reductase
MRRVIQFSTGNVGRHSLRAIIGRPDLELVGVHAAGPEKIGRDAAQLCGLDEPTGIIATDDIDALVALNADCVVYTSQGETRPMDAIEQMSRFLTAGTNVVGTSMVWLVAPRHAEEWLREPLQRACEAGNTSLYVNGIDPGFSGDTLVHAAVSLATRVSSITVQEIFDYGNYDDAEFTGAAMGFGTSPDDDSPMMFLPGVIVAMWGGQVRSLADHLGVELDDVRQRFERWFTPERIDCTMMTVQPGRMAAVRFATEGVRDGEPVITLEHVTRLTRAAAPDWEYPPDGHTGVHRVVVAGEPRVEINTHVSHPLFDSTDAGCISTAARVVNAIDWVCRAPQGLIGVEDIPLAATMRGALWQDR
>NZ_CP016396.1|WP_155251422.1|4495655_4496216_+|pyrazinamidase-PncA
MRALIIVDVQNDFCEGGSVPVAGGAAVAPAINAYLDDAPGYDYVVATQDFHIDPGDHFSDRPDYSSSWPVHCLAGSAGADFRPELDTTRVDAVFRKGAYAAGYSGFEGVDDNGTPLLEWLRRRGVDEVDVVGIATDHCVRRTAEDAARAGLTTRVLVHLTAAAAEDSAARALDEMRSAGIELVGAR
>NZ_CP016396.1|WP_031354786.1|4496215_4497016_+|transporter
MVAPLDRQQLLAAVERSPQAAAEHDRAAWVALFTPDGRIEDPVGSRPHLGRTQIGRFYDTFIGPRDIRFHRDLDIVFGTTVLRDLELEVAMGPAVTMYIPAFLRYDLRETNGEWLIGALRAYWELPAMMVQFLRSGPGAARPAVDLYRGLLRNQGWRGSAGFMAGFRRVGAPHQRLVRRFLDAVAAGDKFAAAQALSSTAAITLGDRDPIELAELAEQLAGAGLTKMNSAGPAVAVSLHSGHGRAIVFADVAWRANAINRIRYFPA
>NZ_CP016396.1|WP_003878038.1|4497029_4497380_-|hypothetical-protein
MNTVFVGIILFTAAITAAIAVADFVPARFVLANSAEVGVPRSWLPALGAAKLAGAAGLVVGLLGLPALGIAAAAGLVVFFVGAVLTHLRAGVLYNIAFPGAYLCLSAASLAWMALR
>NZ_CP016396.1|WP_009976731.1|4497548_4498481_+|sigma-70-family-RNA-polymerase-sigma-factor
MNAPRNLAELAQRFDDDRRHLRSVAFQLLGSLADADDAVQSAWLKASRADFAAVDNLSGWFTTITAREALDQLRARKRRAELPLAAPEELDRLAVPASSPADEDTLLAESVSTALLVVLDRLSPAQRVAFVLHDVFAMPFETIAELLNRSPDAAKKLASRARDRLHAAPAGPPRRDGHRIERHVEVVQAFLAASRGGDIAALLQLLAPDVLRTVDPVLVPADVPTALRGATRVAQETRRFAGRARAGAVMLIDGTPGIVIAARGRAQILLMIGIGADDRIHTIDITGDPERIRRATLALPPAGRFRNITT
>NZ_CP016396.1|WP_009976732.1|4498546_4499875_+|sugar-ABC-transporter-substrate-binding-protein
MLDRPFGRRSLLRGAGALSAAALAPWSAGCGSDDDGALTFFFAANPEERDARMRIIDEFARRHPDIKVRAVLSGPGVMQQLSTFCVGGRCPDVLMAWELSYAELADRGVLLDLGPLLARDKAFAQQLQADSIPALYETFTFNGKQYALPEQWSGNYLFYNKRLFDEAGVPSPPTAWEHPWDFTEFLNAARALTKRDASGRAAQYGFVNTWGSYYSAGLFAMNNGVPWSDPRLNPTHFNFDNAAFQEAVQFYADLANKYRVAPNASETQSMSTPNLFAVGRAAMALGGHWRYQTYIRAEGLDFDVAPLPVGPAVGKGQPACSDIGATGLAISSSSPRKEQAWEFVKFATGPVGQALIGESCLFVPVLRSALKSDGFARAHRRVGNLGVLTDGPAFSQGLPITPAWEKVNALMDRNFGPILRGSRPATSLAGLSRSVDEVLRSP
>NZ_CP016396.1|WP_009976733.1|4499871_4500816_+|sugar-ABC-transporter-permease
MTALDTEAGRRTPKNPSPWRRHAWAGRLFVAPNMVAVAVFMLFPLGFSLYMSFQRWDVFTPPKFVGLKNFTDLFSSDPLFLIAIRNTVIFTLGSVVPTVAISLAVAGVLNQKVRGIGIFRTIVFLPLAISSVVMAVVWQFVFNTDNGLLNIMLGWVGLGPVPWLVEPRWAMASLCIVSVWRSVPFATVVLLAAMQGVPETVYEAARIDGAGEIRQFFAITVPLIRGSISFVVIISIIHAFQAFDMVYVLTGPSGGPESATYVLGIMLFQHAFSFLEFGYASALAWVMFAVLLVLTVVQLRVSHRRSLETSRGLK
>NZ_CP016396.1|WP_003876741.1|4500802_4501645_+|carbohydrate-ABC-transporter-permease
MGSSEAVIKRTVLRAATVYAALLGIAWCALFPIAWAVSGSLKTEGEVSEPTLVPARPRWSNYTEVFALMPIGRMFVNTVLYAGCVTAGHVFFCSLAGYAFARLDFRGRNTLFVVYLGTLMVPLTVTVIPQFLIMRTLGWVDTPWAMIVPGFFGSAFGTYLMRQFFRTLPTDLEEAAILDGCTPWQVYWRILLPHARPAVMVLAVLTWVNVWNDFLWPLLMIQRSSLATLTLGLVRMKGEYVARWPVLMAASMLIMLPLVIIYAIAQRSFVRGIAVTGMGG
>NZ_CP016396.1|WP_029248479.1|4501647_4502733_+|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC
MASVTFQQATRRYPGADRPALDNLNLVVGDGEFVVLVGPSGCGKTTSLRMVAGLETVDSGRILIGDRDVTNVDPKQRDVAMVFQNYALYPHMTVAQNMGFAMKIAKTPKAQIRERVLDAAKLLDLQPYLDRKPKDLSGGQRQRVAMGRAIVRRPQVFLMDEPLSNLDAKLRVQTRNQIAALQRRLGTTTVYVTHDQVEAMTMGDRVAVLRDGVLQQFAPPRELYRNPSNVFVAGFIGSPAMNLFTLPVVDSAVSLGDWPIALPREIAAAASEVVVGVRPEHFELGGLGVEMEVDVVEELGADAYLYGRITGSGKVIDAPIVARVDGRNPPEKGSRVRLHPAPGHLHFFGRNGQRIGVRGSW
>NZ_CP016396.1|WP_003876738.1|4502726_4503695_+|patatin-like-phospholipase-family-protein
MVNTVRADLVCEGGGVRGIGLVGAVDALAAAGYRFPRVAGSSAGAVVASLVAALQTAGEPLSRLTDIMRTIDYRKFLDRNLIGHVPVIGGGLSLLTSDGVYRGAYLEQLLAGLLGDLGVRTFGDLRTGEAPEQFAWSLVVTASDLSRRRLVRIPWDLGSYGIDPDDFPVARAVHASSAIPYVFEPVRVGGATWVDGGLLSDFPVELFDRPDGQPQWPTFGIRLSARPGIPPTHPVHGPVSLGIAAIETLVSNQDNAYIDDPCTVRRTIFVPAEDVSPIDFDITAQQREALYERGRQAGQQFLQTWNYADYLKACGGPVPETP
>NZ_CP016396.1|WP_023884348.1|4503720_4504008_-|DUF3349-domain-containing-protein
MDLAHWVTSIVAFVRAGYPAGMPATGHVPLVALAHRRLCHDDITAIATDLIARRLWPISSVDIGVEITRFTNQLPSPQDVDLVLRPVHAIRCSRG

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Crispr_ID: NZ_CP016396_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016396_5

4560327-4560425

Orphan

Consensus_repeat	Method
CGGTTGCGGCCCGACCCCCAGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016396_5

>merge|NZ_CP016396|5|4560327-4560425|CRISPRCasFinder
CGGTTGCGGCCCGACCCCCAGCGGCCGGCACACGTTGGCCGTCGGGTCCCACCATTGGCCCGGGTCGCAGGCCAACGGTTGCGGCCCGACCCCGAGCGG

>NZ_CP016396|5|5|4560327-4560425|CRISPRCasFinder
CGGTTGCGGCCCGACCCCCAGCGG	CCGGCACACGTTGGCCGTCGGGTCCCACCATTGGCCCGGGTCGCAGGCCAA
CGGTTGCGGCCCGACCCCGAGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016396.1\|WP_009976816.1\|4561220_4562696_+\|biotin-carboxylase	unknown	unknown	gnl\|CDD\|180605
NZ_CP016396.1\|WP_003877996.1\|4552782_4553376_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP016396.1\|WP_023884360.1\|4551856_4552675_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
NZ_CP016396.1\|WP_009976808.1\|4558521_4559364_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378964
NZ_CP016396.1\|WP_009976824.1\|4566255_4566675_+\|Hsp20-family-protein	unknown	unknown	gnl\|CDD\|365807
NZ_CP016396.1\|WP_023880032.1\|4553396_4554281_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|131480
NZ_CP016396.1\|WP_065371144.1\|4563864_4565094_-\|tRNA-4-thiouridine(8)-synthase-ThiI	unknown	unknown	gnl\|CDD\|234960
NZ_CP016396.1\|WP_019732292.1\|4565762_4566143_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133394
NZ_CP016396.1\|WP_009976812.1\|4559869_4560181_+\|DUF732-domain-containing-protein	unknown	unknown	gnl\|CDD\|368380
NZ_CP016396.1\|WP_033716637.1\|4556968_4557679_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181044
NZ_CP016396.1\|WP_065371143.1\|4562692_4563868_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|224594
NZ_CP016396.1\|WP_009976825.1\|4566987_4567308_+\|J-domain-containing-protein	unknown	unknown	gnl\|CDD\|365959
NZ_CP016396.1\|WP_065371142.1\|4556269_4556923_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|188314
NZ_CP016396.1\|WP_003876693.1\|4557860_4558298_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366161
NZ_CP016396.1\|WP_023884364.1\|4570021_4570783_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235816
NZ_CP016396.1\|WP_003877981.1\|4569416_4569974_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|223619
NZ_CP016396.1\|WP_016706318.1\|4565258_4565702_+\|Hsp20-family-protein	unknown	unknown	gnl\|CDD\|365807
NZ_CP016396.1\|WP_009976801.1\|4554425_4556246_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NZ_CP016396.1\|WP_031351645.1\|4559317_4559719_+\|glyoxalase	unknown	unknown	gnl\|CDD\|319943
NZ_CP016396.1\|WP_065371145.1\|4567360_4568767_-\|acyltransferase	unknown	unknown	gnl\|CDD\|334202

Protein	Function_ID	Function_description	E-value
NZ_CP016396.1\|WP_009976816.1\|4561220_4562696_+\|biotin-carboxylase	gnl\|CDD\|180605	PRK06524, PRK06524, biotin carboxylase-like protein; Validated.	0
NZ_CP016396.1\|WP_003877996.1\|4552782_4553376_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.77542e-08
NZ_CP016396.1\|WP_023884360.1\|4551856_4552675_-\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	5.9076e-44
NZ_CP016396.1\|WP_009976808.1\|4558521_4559364_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|378964	pfam12833, HTH_18, Helix-turn-helix domain.	2.30667e-14
NZ_CP016396.1\|WP_009976824.1\|4566255_4566675_+\|Hsp20-family-protein	gnl\|CDD\|365807	pfam00011, HSP20, Hsp20/alpha crystallin family. Not only do small heat-shock-proteins occur in eukaryotes and prokaryotes but they have also now been shown to occur in cyanobacterial phages as well as their bacterial hosts.	1.2009e-29
NZ_CP016396.1\|WP_023880032.1\|4553396_4554281_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	3.43574e-32
NZ_CP016396.1\|WP_065371144.1\|4563864_4565094_-\|tRNA-4-thiouridine(8)-synthase-ThiI	gnl\|CDD\|234960	PRK01565, PRK01565, thiamine biosynthesis protein ThiI; Provisional.	4.07364e-177
NZ_CP016396.1\|WP_019732292.1\|4565762_4566143_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|133394	cd04766, HTH_HspR, Helix-Turn-Helix DNA binding domain of the HspR transcription regulator. Helix-turn-helix (HTH) transcription regulator HspR, N-terminal domain. Heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	8.83307e-37
NZ_CP016396.1\|WP_009976812.1\|4559869_4560181_+\|DUF732-domain-containing-protein	gnl\|CDD\|368380	pfam05305, DUF732, Protein of unknown function (DUF732). This family consists of several uncharacterized Mycobacterium tuberculosis and leprae proteins of unknown function.	5.27315e-12
NZ_CP016396.1\|WP_033716637.1\|4556968_4557679_-\|SDR-family-oxidoreductase	gnl\|CDD\|181044	PRK07577, PRK07577, SDR family oxidoreductase.	5.84864e-140
NZ_CP016396.1\|WP_065371143.1\|4562692_4563868_+\|serine-hydrolase	gnl\|CDD\|224594	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms].	1.74565e-32
NZ_CP016396.1\|WP_009976825.1\|4566987_4567308_+\|J-domain-containing-protein	gnl\|CDD\|365959	pfam00226, DnaJ, DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.	1.61446e-18
NZ_CP016396.1\|WP_065371142.1\|4556269_4556923_-\|HD-domain-containing-protein	gnl\|CDD\|188314	TIGR03401, Uncharacterized_protein_YFL061W/YNL335W, HD domain protein, cyanamide hydratase family. Members of this protein family are known, so far, in the Ascomycota, a branch of the Fungi, and contain an HD domain (pfam01966), found typically in various metal-dependent phosphohydrolases. The only characterized member of this family, from the soil fungus Myrothecium verrucaria, is cyanamide hydratase (EC 4.2.1.69), a zinc-containing homohexamer that adds water to the fertilizer cyanamide (NCNH2), a nitrile compound, to produce urea (NH2-CO-NH2). Homologs are likely to be nitrile hydratases.	6.68974e-13
NZ_CP016396.1\|WP_003876693.1\|4557860_4558298_-\|hypothetical-protein	gnl\|CDD\|366161	pfam00553, CBM_2, Cellulose binding domain. Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.	1.7951e-36
NZ_CP016396.1\|WP_023884364.1\|4570021_4570783_-\|SDR-family-oxidoreductase	gnl\|CDD\|235816	PRK06500, PRK06500, SDR family oxidoreductase.	8.05892e-71
NZ_CP016396.1\|WP_003877981.1\|4569416_4569974_+\|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	8.29746e-24
NZ_CP016396.1\|WP_016706318.1\|4565258_4565702_+\|Hsp20-family-protein	gnl\|CDD\|365807	pfam00011, HSP20, Hsp20/alpha crystallin family. Not only do small heat-shock-proteins occur in eukaryotes and prokaryotes but they have also now been shown to occur in cyanobacterial phages as well as their bacterial hosts.	1.21106e-29
NZ_CP016396.1\|WP_009976801.1\|4554425_4556246_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	0
NZ_CP016396.1\|WP_031351645.1\|4559317_4559719_+\|glyoxalase	gnl\|CDD\|319943	cd08355, TioX_like, Micromonospora sp. TioX and similar proteins. Micromonospora sp. TioX is encoded by a gene of the thiocoraline biosynthetic gene cluster. Thiocoraline is a thiodepsipeptide with potent antitumor activity. TioX may be involved in thiocoraline resistance or secretion. TioX belongs to vicinal oxygen chelate (VOC) superfamily that is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.14886e-32
NZ_CP016396.1\|WP_065371145.1\|4567360_4568767_-\|acyltransferase	gnl\|CDD\|334202	pfam00668, Condensation, Condensation domain. This domain is found in many multi-domain enzymes which synthesize peptide antibiotics. This domain catalyzes a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pfam00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site.	6.05817e-19

>NZ_CP016396.1|WP_009976812.1|4559869_4560181_+|DUF732-domain-containing-protein
MIGAALVGGAGIAAATPQDDAYLAQLRAAGLTWPPKTEEALIAEAHDVCYDLTWGWTPQQIADDLHARLDNKGVTLLDVGSLVNAAHNIYCPGNVCDAPSLCT
>NZ_CP016396.1|WP_031351645.1|4559317_4559719_+|glyoxalase
MTASNPTVWLTLQAHNAPKLIDYYVETFGFVLTARYGDGETVDHAQLNWPEGSGGIMLGSHKPGAEWCREPGTAGGYVVTADPDALYRRVRQHNAEIVRPLAETDYGAREFTVRDPEGNLWSFGDYGGANPPN
>NZ_CP016396.1|WP_009976808.1|4558521_4559364_+|AraC-family-transcriptional-regulator
MVGYRTLDVPEGVHRGMPSSMLTFIVSLDDGVEAADTATALPAARPTPLILGGLHLRASHVRQRRGQAGVQLAVHPLASRALFGLPSAELPVAEYDATAVLGRDIVDLHHRVAEAHRWPDVFALVAQYLIDARRRRDGATVRPEVLHAWHLLQRSRGLIPVTALADAVGVTTRHLATLFRREVGHSPKTVAMLMRFQHATGRIAESARRHGRVDLARVAADTGYSDQAHLSREFVRFAGVPPQRWLAEEFRNIQDGGHSLGSQWEHDCFESDRLVDTASP
>NZ_CP016396.1|WP_003876693.1|4557860_4558298_-|hypothetical-protein
MAGLDNHLKRCRTALHGAVSAVIVAVVAVLGLAIAPVADAAAPMATLTVEHTWQTGFIARFAITNSSTVPLSDWKLEFDMPAGQSVLHTWNSTLTQSGTHYVLTPANWNRVIAPGGSATGGFRGVLTGTYSPPTNCVLNGQYRCT
>NZ_CP016396.1|WP_033716637.1|4556968_4557679_-|SDR-family-oxidoreductase
MPSRRVLITGASRGIGRAVADRLAEGGHEPIGLARSAPKDFPGEFYEVDLADPYATAATLDKIVGHAAVHAVVNNVGFARFGRLGSIELDHLFDTYDLNVRAAVQVVQAALPGMLDAEWGRIVNVTSLTTLGTPERTPYAAAKAALEACTRIWAGELASAGITVNAVAPGPTETDMYRERSPVGSEREARFLQSIPLHRVARPREIAHAICFLLDEDAGYITGQILRVDGGGSIAA
>NZ_CP016396.1|WP_065371142.1|4556269_4556923_-|HD-domain-containing-protein
MTTTSSIETIADIAIPDTALVREITEFIRDAEDDLLFHHSRRVFLFGALQGRRRGLQPDLELLYAGAMFHDLGLTERYRDSALRFEVDGANAAREFLLHRGVSKADADKVWLGIALHTTPGVPEFLDPEIALVTAGVETDVVGVGCDDLAPEALAAVIAAHPRPDFKTRILQAFNDGMKHRPHSTFGTMNADVLEHFDPTFARDNFVDLILNNGWPE
>NZ_CP016396.1|WP_009976801.1|4554425_4556246_+|long-chain-fatty-acid--CoA-ligase
MTHAPASRPTTLCEAFQATAAKHPDAVALRTLGDATTITWRQYRDRVRAIAAGLAGLGVGNGDTVALMMSNRPEFHLCDTAVLHTGATPFSVYNTNPPELLAYQFDNADNHVVICEGTFLPQVLAAAQQGGTVEHVVCVDGAANGAIGLGQLEASPAADFDFERSWRAVGPDDVLTIVYTSGTTGPPKGVELTHTNFIENARITEEVGGITHADRAVSYLPDAHAANRWITHYQNLLYGLQITTVGDFKAVLPALTEVRPTLFLGVPRVWIKAKAGLEAAVDAEPAGKRALAKWAFGVGRARARAVSDGRPVGLAEKLRYAFADRLVLSKVRRRLGMDRLRIGVTGAAPIPREVHEFVLGLGIPVCEGYGMTECTAGATVNRPERIKIGTVGTPVPGTEVTVASDGEVLVRGKNVMRGYRKAPEKTAEAIDSDGWLHTGDIGEIDEDGYLRIVDRKKELIINAAGKNMSPTNIENTIAASCPLAGPVVVIGDARAYNTALITLDPDSVTEYAHAHGLSGSLRELVRNPAVRAEIEKGMAAANRRLSRVEQIKRYTVLADVWEPGSQYLTPTAKLKRKPIATGYAAQIDAMYTEQGKRSAGHSAASD
>NZ_CP016396.1|WP_023880032.1|4553396_4554281_-|alpha/beta-fold-hydrolase
MFREPRVAYDATTVATHDGAQLHVRSYGSAFGQPIVLIHGFGCRIEYWNPQINALAAKYRVIAYDQRGLGRSTLGSDGVRPDVLGRDLAAVLDAVLAPGERAVLVGHSFGGITIMAWAQRFAAHAVSAVLLANTIAERFSATTMLLPFADRYRHIRRPLITALAGSTMTLPSIRWSRWPLQRMALSRYADRQAVDFVYEILADCRTDVRAVWGAGLSGLDVTAGLEKLTVPTTVVTGTEDRLTPPAVAHRIAEALQVRGSLHRFARFPRAGHCTNIEVPYAFNAEIEQLADATR
>NZ_CP016396.1|WP_003877996.1|4552782_4553376_+|TetR/AcrR-family-transcriptional-regulator
MVMTNPRATNEDLTAKARIRNAALDLYAQYGEDRISLRDIASAAGVTLGLVQHHFKTKAGVRDAVDQLVVDYFAHALAQVPAEGSARHVAAARDEAVARMLRDNPPVVNYVRRAVLDPSEDRLHLLDALIELTRREITALRGSGMASTKRPESTQILGVLIRQMGELLLQPMVDAVWDRVAKPTDARKPRLRITVEN
>NZ_CP016396.1|WP_023884360.1|4551856_4552675_-|CoA-transferase
MQPLIGVTVVSLAVNLPGPLAAARLAELGAAVTKVEPATGDPLAAAAPDWYARLIEHQNVLTLDLKDTGDRAKLDELLAGADLLITSMRPSALHRSGLARPQQKFPRLSLIEIVGHHGERAETPGHDLNYQAAQGTLTPPHMPKVPIADVLGAERAVSSALAALLQAAKAGAGQRYRVVLEEAAARAGDAVRYGLMGEGAVLGGAYPGYGIYASADGYVALGAIEPHFFARTCQVFGADGSHESLGAAFAAKTTAELEDLARHMDIPLNEVR
>NZ_CP016396.1|WP_009976816.1|4561220_4562696_+|biotin-carboxylase
MTHAGEPQPRRVLNGLSDIRAFFHTNSVPLYFISPTPFNLLGIDRWIRNFFYLTYFDSFEGIHSRVFVPRRRDRIDFDSMGDVCNHLLRDPETLEFIAGRGPGGKACFVMMDEETQALARQAGLQVMHPPVELRNRLGSKTVMTRLADEAGIPSVPHVMGRAGSYQELLTLAQDAGLGDDLVVSIPYGAAGSGTFFVRGQRDWDEHAGDLTAQQEFKVMKRIRNVEVCLEGAVTRHGTVIGPAMTSLVGYPELTPHRGAWCGNDIWREVLPPGQTHAARQMVGKLGDILSREGYRGYFEVDLLHDLDSDELYLGEVNPRLSGASPMTNLTTEAYADMPLFLFHLLEYMDVDYELDIEGINARWERGYGEDEVWGQVILAETSPDVELFTATPRTGVWRIDDDGRVSFSRTANDWATLLDGSEAFYMRVAAPGDLRSEGAQLGVLVTRGHLQTDDYRLTERCQRWVKGMKAKFASTPLAPATPIVSRLVARA
>NZ_CP016396.1|WP_065371143.1|4562692_4563868_+|serine-hydrolase
MNAPAGISLDNWLSPPYARWSFQHLEDFVPTAVIARGTGPVAAIPAAPSELAEIRVAVTDGTASTVGAVMAGTATDGWAVAHRGAMIAEHYLEGMRRQTRHLLFSVSKSLVAAVVGALHGAGAIELDAPVTKYIPALANCGYAGATVRHLLDMRSGVAFSENYDDPAAQIHLLDQAVGWAPNHRPDAPATLRDFLLTLRQKSVQGGPFEYRSCETDVLGWICEVAADQPMPALMSELLWSRIGAQRDATIAVDPAGTGFFDGGISACLTDMIRFGSLFLREGVSLTGRRVLPEAWIADTLAGGPDSRRAFAASPDDNEMPGGMYRNQMWLPYPGDNVLLCLGMCGQMIYVNRAAEMVAAKVSTQPHSHEPHMLDTLSAFDAIAHRLAGRTD
>NZ_CP016396.1|WP_065371144.1|4563864_4565094_-|tRNA-4-thiouridine(8)-synthase-ThiI
MHMQCCVLLKYGEMVLKGGNRRWFEQWLLTNLDDALSAWPPEHRPAVRRRGGVLVLFTSPELQDELVALARNLIGISLVQPVWRVPRSARAAETAAVELLRDHRTQDGAPTFAVRCHRRDKRFGLSSEQLAARIGARVRADLGWRVDLSHPELELTVEVDRREIFLGTRTHPGQGGLPVGSSGRAVVLLSGGFDSPVAAYRAMRRGLACDFLHCTGAPFTDASSTYKAYALVRQLTRFQPRSRLYVAAVGRAQRTLAASGAGEAQIVAQRRLYLRLACGLAERIGAQAVVTGDSLGQVASQTLPNLAATAQAATLPVLRPLLGFDKQEILAEARRIGTAEIAMLPDQDCCQLFLPRRVATHAAVDQLLPVEARAGVDTLVGNLLDRMQRFDFGPEAADVESAATTSRVG
>NZ_CP016396.1|WP_016706318.1|4565258_4565702_+|Hsp20-family-protein
MVNMLRFDPFFRDIDRLTQQLWGAVPWGTAAQPALVPMDAWRDGEKFVVEFDLPGVLPESLDVNVEHDVLTVRAERPAIDEDRNGVVSERPRGVFSRQVYLGHGLDTDNIHADYVDGVLRLTIPVAEAAKPRKIEVAAGKHQRAINA
>NZ_CP016396.1|WP_019732292.1|4565762_4566143_-|helix-turn-helix-transcriptional-regulator
MRGDPTPRSARGVYGISVASELSGIPPQTLRHYERRGLLTPARSDGGTRRYSDDDLARLKRISQLVDQGVNLVGVARILDLESKNDQLKADYSALELLNAKLKTRQKSERAAAPRQCRGEARREAV
>NZ_CP016396.1|WP_009976824.1|4566255_4566675_+|Hsp20-family-protein
MVLMRTDPFRDLDRWTQQVLGTAARPAVMPMDAWRDGDQFVVEFDLPGVNADSLDLDVERNVLTVRAERPDLDQNREMVSAERPRGVFSRQLFLGDNLDTDKIEANYHDGVLRLTIPVAEKAKPRRIEINHNHRTAINA
>NZ_CP016396.1|WP_009976825.1|4566987_4567308_+|J-domain-containing-protein
MTNPYLVLGVSPTATQAEITRAYRRHLRAHHPDTSPPDSATESSERLSEILAAYALLRDPARRADYDREHRVHQRIRPAVTRVTRIEPADEQPPLRAGPVRWHRRY
>NZ_CP016396.1|WP_065371145.1|4567360_4568767_-|acyltransferase
MPASYQQLHHLRRFSEHAARGLDMARLNIGVWDISGVCDVAAMTEAINAHLRRHDTYHSWFEHRTDGRIVRHTFADPADIEFAALQRGEMTPTKLRAHILATPNPLRWDCFTFGLVQHPDHFTFYMSADHLVIDGMSVGVIFLEIHLTYAALVSGGRPLPLPEPASYHDYCRRQHQHTEALTLQSPQVRAWIRFAQDNGGTLPSFPLPLGDPSVPCGSGVVVAPLMDESQTERFDATCTKAGARFSGGVFACAAFAEYELTGAETYCAITPYDHRSTPAEFVTPGWFASFIPVTVPVAGASFGDAVIAAQASFDSAIGLADVPFDRVLELSSFGGRISKPTGDVHMLSFADARGIPFSGQWDGLNAGIYGDGRSSDQVLMWVNRFDTETTLTVAFPQNPVARDSVERYIRAVRAMCLRVVEHGAAAVPNRRRVVAAVNASAARSTANAADRTDRRLQGAGFGANPVLR
>NZ_CP016396.1|WP_003877981.1|4569416_4569974_+|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MNSVRTFSAAAFAACFTAAAAMLAGAGTAGAADSCPTAAPPSGGTPDWTLTGTTGSVAVTGSTDTAAPVVNVTAPFSVTQTQVHTLRAGDGPAVPGTARVSVCYMGVNGRDGTVFDSSYQRGAPVDFPLGGVVPGFQKAIAGQKVGSTVAVAMTSADGYPDGQPSAGIRPGDTLVFAIKILGATT
>NZ_CP016396.1|WP_023884364.1|4570021_4570783_-|SDR-family-oxidoreductase
MGLLDRKTAVITGANSGIGLATAERFLAEGVERVFITGRRQRELEDAARQLGPRATAVRGDVGAPRDLDRLYCKVAAAGAGLDIVMANAGTTRVARLGEITDDDLDTLLGTNVKGVVYTVQKALPLLNDGASIILTGSTTADRGRAGLSIYAATKAAVRSLARAWANELAHRNIRVNVLVAGSTATPGSDRLAAQTDPYASVEEFRAGRIATIPLGRFADPVEIAHAAVFLASDLSSFCTGSTVTADGGFNQV

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP016396_3	3.1\|3360060\|25\|NZ_CP016396\|CRISPRCasFinder	3360060-3360084	25	NZ_CP030127	Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence	891602-891626	5	0.8
NZ_CP016396_2	2.1\|1943017\|31\|NZ_CP016396\|CRISPRCasFinder	1943017-1943047	31	NZ_CP032685	Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence	1428865-1428895	8	0.742
NZ_CP016396_2	2.1\|1943017\|31\|NZ_CP016396\|CRISPRCasFinder	1943017-1943047	31	NZ_CP032690	Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence	1428843-1428873	8	0.742
NZ_CP016396_1	1.1\|449108\|34\|NZ_CP016396\|CRISPRCasFinder	449108-449141	34	NZ_CP014802	Salipiger profundus strain JLT2016 plasmid pTPRO6, complete sequence	180241-180274	9	0.735

1. spacer 3.1|3360060|25|NZ_CP016396|CRISPRCasFinder matches to NZ_CP030127 (Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.8

ggggtcagattgcccggctcctcct	CRISPR spacer
aatgtcagatagcccggctcctccg	Protospacer
.. ******* *************

2. spacer 2.1|1943017|31|NZ_CP016396|CRISPRCasFinder matches to NZ_CP032685 (Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence) position: , mismatch: 8, identity: 0.742

cccctcaggggccgacggttcggcttgctcc	CRISPR spacer
atcaggcggggccgacggttccgcctgctcc	Protospacer
 .*    ************** **.******

3. spacer 2.1|1943017|31|NZ_CP016396|CRISPRCasFinder matches to NZ_CP032690 (Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence) position: , mismatch: 8, identity: 0.742

cccctcaggggccgacggttcggcttgctcc	CRISPR spacer
atcaggcggggccgacggttccgcctgctcc	Protospacer
 .*    ************** **.******

4. spacer 1.1|449108|34|NZ_CP016396|CRISPRCasFinder matches to NZ_CP014802 (Salipiger profundus strain JLT2016 plasmid pTPRO6, complete sequence) position: , mismatch: 9, identity: 0.735

gcgcccgagttgtcggccggcgcccgagttgtgt---	CRISPR spacer
gcgcccgcgttgtcgcccggcgcc---accatgtcga	Protospacer
******* ******* ********   ....***

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

289102 : 360151

Corynebacterium_phage(28.57%)

transposase,integrase

attL 282557:282576|attR 354515:354534

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
282557:282576	attL	NA	NA	NA	NA
WP_011724852.1\|289102_290683_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_128971849.1\|291096_292260_-	hypothetical protein	NA	NA	NA	NA
WP_121035649.1\|292602_293823_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.8e-62	40.3
WP_029248429.1\|293744_294851_+\|integrase	tyrosine-type recombinase/integrase	A0A220NQQ9	Corynebacterium_phage	1.9e-10	32.2
WP_085988246.1\|294901_297079_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_009980034.1\|297068_297500_+	hypothetical protein	NA	NA	NA	NA
WP_011724255.1\|298502_299534_+	hotdog fold thioesterase	NA	NA	NA	NA
WP_009975831.1\|299633_300842_+	amidohydrolase	NA	NA	NA	NA
WP_011724254.1\|300903_301275_+	hypothetical protein	NA	NA	NA	NA
WP_009975830.1\|301219_301522_-	hypothetical protein	NA	NA	NA	NA
WP_009975829.1\|301523_303014_-	molybdopterin-dependent oxidoreductase	NA	NA	NA	NA
WP_011724253.1\|303027_303537_-	hypothetical protein	NA	NA	NA	NA
WP_011724252.1\|303783_305751_+	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_065370722.1\|305747_306989_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_023879828.1\|306985_308134_-	acyl-CoA/acyl-ACP dehydrogenase	NA	NA	NA	NA
WP_009975823.1\|308347_309307_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_009975822.1\|309600_310833_+	cytochrome P450	NA	NA	NA	NA
WP_065370723.1\|310829_311987_+	Zn-dependent alcohol dehydrogenase	E3SJ82	Synechococcus_phage	2.6e-34	30.6
WP_011724248.1\|311994_313899_-	YhgE/Pip domain-containing protein	NA	NA	NA	NA
WP_019732717.1\|313902_314580_-	hypothetical protein	NA	NA	NA	NA
WP_009975817.1\|314603_315221_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_023884191.1\|315296_316121_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_020371241.1\|316178_317399_-	cytochrome P450	NA	NA	NA	NA
WP_023884190.1\|317580_319077_+	multidrug ABC transporter ATPase	NA	NA	NA	NA
WP_050680726.1\|319149_320223_-	TIGR03857 family LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_003873147.1\|320186_320567_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_009975810.1\|320566_321688_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_009975809.1\|321702_323325_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_009975808.1\|323441_324455_+	Rieske (2Fe-2S) protein	NA	NA	NA	NA
WP_009975807.1\|324451_325081_+	cysteine hydrolase	NA	NA	NA	NA
WP_009975806.1\|325077_325710_+	PaaI family thioesterase	NA	NA	NA	NA
WP_065370724.1\|325718_327371_+	acyl-CoA synthetase	A0A2K9L3I8	Tupanvirus	2.8e-05	20.5
WP_009975803.1\|328383_329586_+	cytochrome P450	NA	NA	NA	NA
WP_011724241.1\|329608_330823_+	CoA transferase	NA	NA	NA	NA
WP_009975800.1\|330877_332023_+	thiolase family protein	NA	NA	NA	NA
WP_011724240.1\|332139_333333_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_003873159.1\|333333_334380_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_065370725.1\|334382_335213_-	amidohydrolase family protein	NA	NA	NA	NA
WP_003873162.1\|336868_338071_-	amidohydrolase	NA	NA	NA	NA
WP_009975795.1\|338090_338915_-	enoyl-CoA hydratase	NA	NA	NA	NA
WP_003873164.1\|339226_339469_+	hypothetical protein	NA	NA	NA	NA
WP_023879827.1\|339522_340539_-	dihydrodipicolinate synthase family protein	NA	NA	NA	NA
WP_009975793.1\|340583_341381_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_009975791.1\|341561_342365_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_009975789.1\|342384_343275_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_009974923.1\|343506_344712_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_080555730.1\|344730_345138_-	hypothetical protein	NA	NA	NA	NA
WP_009975754.1\|346213_346666_+	hypothetical protein	NA	NA	NA	NA
WP_009975755.1\|346843_347206_+	hypothetical protein	NA	NA	NA	NA
WP_009975756.1\|347559_350169_+	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	1.4e-32	28.9
WP_009975757.1\|350165_351902_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.7e-24	28.6
WP_023884184.1\|351980_353057_+	phosphotransferase	NA	NA	NA	NA
WP_003873183.1\|353061_353490_-	pyridoxamine 5'-phosphate oxidase	NA	NA	NA	NA
WP_062886559.1\|354359_355553_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
354515:354534	attR	NA	NA	NA	NA
WP_015632616.1\|355720_356470_+	3-oxoacyl-ACP reductase FabG	Q06VL0	Trichoplusia_ni_ascovirus	5.5e-09	25.3
WP_065370726.1\|356466_357687_+	acetyl-CoA C-acetyltransferase	NA	NA	NA	NA
WP_003873178.1\|357688_358888_+	dehydratase	NA	NA	NA	NA
WP_009974923.1\|358945_360151_-\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

862028 : 895195

Mycobacterium_phage(42.86%)

transposase,terminase,capsid,portal,integrase

attL 858030:858045|attR 899223:899238

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
858030:858045	attL	NA	NA	NA	NA
WP_011723914.1\|862028_863081_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_023884559.1\|863095_864010_+	SAM-dependent methyltransferase	NA	NA	NA	NA
WP_009975191.1\|864027_865965_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_065370771.1\|865961_868262_-	ATP-dependent DNA ligase	A0A291AUP8	Sinorhizobium_phage	7.7e-38	36.1
WP_065370772.1\|868540_870034_+	mannitol dehydrogenase family protein	E5EQS6	Micromonas_sp._RCC1109_virus	7.2e-53	32.0
WP_009975185.1\|870030_870891_+	HAD family hydrolase	NA	NA	NA	NA
WP_009975183.1\|871018_872431_+	mannitol dehydrogenase family protein	NA	NA	NA	NA
WP_009975181.1\|872427_873336_+	carbohydrate kinase	NA	NA	NA	NA
WP_009975180.1\|873373_874282_+	Ku protein	A0A249XRB2	Mycobacterium_phage	6.9e-67	50.4
WP_009975179.1\|874287_875196_-	phosphate ABC transporter permease PstA	NA	NA	NA	NA
WP_009975178.1\|875192_876179_-	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
WP_010949005.1\|876185_877295_-	phosphate ABC transporter substrate-binding protein PstS	NA	NA	NA	NA
WP_023884562.1\|877789_878581_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_009975173.1\|878605_879682_+	diacylglycerol kinase	NA	NA	NA	NA
WP_003877474.1\|879778_881005_+	divalent metal cation transporter	NA	NA	NA	NA
WP_009975171.1\|881005_882085_+	replication protein	NA	NA	NA	NA
WP_009975169.1\|882092_882917_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_009979999.1\|883398_884193_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.6e-30	33.9
WP_011724852.1\|884189_885770_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_065370773.1\|885822_886125_-	hypothetical protein	NA	NA	NA	NA
WP_023879603.1\|886124_886985_-\|capsid	phage major capsid protein	NA	NA	NA	NA
WP_023879602.1\|887068_887410_-	hypothetical protein	A0A173G9N0	Mycobacterium_phage	8.4e-34	59.8
WP_050427686.1\|887406_887814_-	hypothetical protein	NA	NA	NA	NA
WP_009978425.1\|887873_889247_-\|portal	phage portal protein	A0A2H4JAT8	uncultured_Caudovirales_phage	3.5e-46	32.2
WP_029248570.1\|889271_890741_-\|terminase	terminase	NA	NA	NA	NA
WP_128971797.1\|890825_891224_+	hypothetical protein	NA	NA	NA	NA
WP_009978428.1\|891594_891876_+	hypothetical protein	NA	NA	NA	NA
WP_080555761.1\|891991_892456_-	hypothetical protein	NA	NA	NA	NA
WP_128971796.1\|893695_893956_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_009978430.1\|894100_895195_-\|integrase	site-specific integrase	A0A088F8U2	Mycobacterium_phage	1.2e-105	53.7
899223:899238	attR	NA	NA	NA	NA

DBSCAN-SWA_3

2198427 : 2243478

uncultured_Mediterranean_phage(25.0%)

transposase,holin,integrase,protease

attL 2194154:2194170|attR 2216566:2216582

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2194154:2194170	attL	NA	NA	NA	NA
WP_009974923.1\|2198427_2199633_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_065370929.1\|2199795_2201433_-	DUF3662 domain-containing protein	NA	NA	NA	NA
WP_009974187.1\|2201939_2202377_+	hypothetical protein	NA	NA	NA	NA
WP_009974189.1\|2202397_2202760_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_009974190.1\|2202799_2203297_-	DinB family protein	NA	NA	NA	NA
WP_023886092.1\|2203484_2205386_+	TNT domain-containing protein	NA	NA	NA	NA
WP_016705393.1\|2205607_2205862_+	hypothetical protein	NA	NA	NA	NA
WP_011724852.1\|2206261_2207842_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_009979999.1\|2207838_2208633_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.6e-30	33.9
WP_009980034.1\|2209341_2209773_-	hypothetical protein	NA	NA	NA	NA
WP_085988246.1\|2209762_2211940_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_029248429.1\|2211990_2213097_-\|integrase	tyrosine-type recombinase/integrase	A0A220NQQ9	Corynebacterium_phage	1.9e-10	32.2
WP_065370931.1\|2214282_2215488_-	DNA polymerase III subunit delta'	NA	NA	NA	NA
WP_010948854.1\|2215586_2217248_+	adenylate/guanylate cyclase domain-containing protein	A0A1B1IWY2	uncultured_Mediterranean_phage	8.4e-18	32.8
2216566:2216582	attR	NA	NA	NA	NA
WP_009974717.1\|2217244_2220043_-	type I DNA topoisomerase	A0A2K9L5F8	Tupanvirus	8.6e-100	30.7
WP_011723615.1\|2220247_2220838_-	hypothetical protein	NA	NA	NA	NA
WP_003419650.1\|2221026_2221230_-	cold-shock protein	A0A1X9IGI9	Lactococcus_phage	2.0e-14	56.2
WP_009974715.1\|2221478_2223809_+	DEAD/DEAH box helicase	NA	NA	NA	NA
WP_003873275.1\|2223891_2224929_+	hypothetical protein	NA	NA	NA	NA
WP_080516381.1\|2224925_2225294_-	helicase	NA	NA	NA	NA
WP_033722333.1\|2225250_2225517_-	hypothetical protein	NA	NA	NA	NA
WP_009974713.1\|2225576_2225777_-	DUF4244 domain-containing protein	NA	NA	NA	NA
WP_065371194.1\|2225795_2226383_-	hypothetical protein	NA	NA	NA	NA
WP_065370932.1\|2226405_2227209_-	hypothetical protein	NA	NA	NA	NA
WP_023884919.1\|2227205_2228381_-	TadA family conjugal transfer-associated ATPase	NA	NA	NA	NA
WP_011723573.1\|2228377_2229430_-	hypothetical protein	NA	NA	NA	NA
WP_003877071.1\|2229942_2230800_+	HAD-IB family hydrolase	NA	NA	NA	NA
WP_003877070.1\|2231265_2232024_-	hypothetical protein	NA	NA	NA	NA
WP_031348150.1\|2232013_2233660_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	8.0e-13	28.0
WP_009974705.1\|2233656_2234532_-	ABC transporter permease	NA	NA	NA	NA
WP_009974704.1\|2234524_2235451_-	ABC transporter permease	NA	NA	NA	NA
WP_023861983.1\|2235452_2237078_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_009974702.1\|2237163_2237706_-	DUF4232 domain-containing protein	NA	NA	NA	NA
WP_009974701.1\|2237820_2239773_+	acetate--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	5.8e-87	39.4
WP_003877062.1\|2239894_2240566_-	peptidase	NA	NA	NA	NA
WP_009974700.1\|2240786_2241326_+\|holin	phage holin family protein	NA	NA	NA	NA
WP_003873293.1\|2241326_2242292_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_003877060.1\|2242284_2243478_-\|protease	acid resistance serine protease MarP	A0A1B1IRH0	uncultured_Mediterranean_phage	2.6e-05	25.0

DBSCAN-SWA_4

3103628 : 3110200

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_009978328.1\|3103628_3104561_+	SDR family oxidoreductase	W8CYX9	Bacillus_phage	4.6e-05	35.9
WP_065371011.1\|3104495_3105539_-	DNA polymerase IV	F1C5A5	Cronobacter_phage	4.7e-19	27.9
WP_009978325.1\|3105538_3106153_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_003874932.1\|3106246_3106801_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	5.4e-06	33.6
WP_003874933.1\|3107330_3107570_+	redoxin NrdH	V5UN81	Mycobacterium_phage	2.0e-21	64.5
WP_065371012.1\|3107612_3108065_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A142F1R4	Bacillus_phage	4.9e-13	36.9
WP_024636978.1\|3108034_3110200_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	7.4e-208	51.6

DBSCAN-SWA_5

3454542 : 3473084

Enterobacteria_phage(40.0%)

transposase,integrase

attL 3449735:3449749|attR 3476334:3476348

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
3449735:3449749	attL	NA	NA	NA	NA
WP_011724852.1\|3454542_3456123_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_009979999.1\|3456119_3456914_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.6e-30	33.9
WP_081304380.1\|3457073_3457319_+	DUF3761 domain-containing protein	NA	NA	NA	NA
WP_155763156.1\|3457708_3458287_-	hypothetical protein	NA	NA	NA	NA
WP_155763157.1\|3458283_3459642_-	hypothetical protein	NA	NA	NA	NA
WP_029248429.1\|3460963_3462070_+\|integrase	tyrosine-type recombinase/integrase	A0A220NQQ9	Corynebacterium_phage	1.9e-10	32.2
WP_085988246.1\|3462120_3464298_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_009980034.1\|3464287_3464719_+	hypothetical protein	NA	NA	NA	NA
WP_011724852.1\|3465161_3466742_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_009979999.1\|3466738_3467533_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.6e-30	33.9
WP_128971805.1\|3468034_3468526_-	hypothetical protein	NA	NA	NA	NA
WP_023879706.1\|3469674_3470844_+\|integrase	tyrosine-type recombinase/integrase	A0A1D8EV90	Mycobacterium_phage	1.7e-62	39.2
WP_023879707.1\|3471120_3471381_+	excisionase family DNA-binding protein	A0A2P1CHK7	Mycobacterium_phage	1.8e-15	66.7
WP_080555769.1\|3471671_3473084_-\|transposase	IS110 family transposase	NA	NA	NA	NA
3476334:3476348	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP016396

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection