CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP016594	Gordonia terrae strain 3612 chromosome, complete genome	12 crisprs	csa3,cas3,DinG,DEDDh,cas4,WYL,RT	0	2	2	0

1. NZ_CP016594

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP016594_1

• CRISPR_ID: NZ_CP016594_1
• CRISPR_location: 712588-712701
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016594_1

Consensus_repeat	Method
GCTATCGCTCCTCGCACCTCAGGGAGCAGAGGG	CRISPRCasFinder

spacers of NZ_CP016594_1

>1.1|712621|48|NZ_CP016594|CRISPRCasFinder
GGGCTCGTCGACCTCGACGCGCTCCTTCGTCGCTCACTCGGCCCGGCG

CRISPR arrays and Neighbor proteins around NZ_CP016594_1

CRISPR arrays

The CRISPR arrays of NZ_CP016594_1

>merge|NZ_CP016594|1|712588-712701|CRISPRCasFinder
GCTATCGCTCCTCGCACCTCAGGGAGCAGAGGGGGGCTCGTCGACCTCGACGCGCTCCTTCGTCGCTCACTCGGCCCGGCGGCTAACGCTCCTCGCACCTCAGGGAGCAGAGGG

>NZ_CP016594|1|1|712588-712701|CRISPRCasFinder
GCTATCGCTCCTCGCACCTCAGGGAGCAGAGGG	GGGCTCGTCGACCTCGACGCGCTCCTTCGTCGCTCACTCGGCCCGGCG
GCTAACGCTCCTCGCACCTCAGGGAGCAGAGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016594.1|WP_033206180.1|712821_714141_-|SidA/IucD/PvdA-family-monooxygenase	unknown	unknown	gnl|CDD|226017
NZ_CP016594.1|WP_004019736.1|715732_717235_-|peptide-synthetase	unknown	unknown	gnl|CDD|380462
NZ_CP016594.1|WP_110117463.1|717222_719562_-|penicillin-acylase-family-protein	unknown	unknown	gnl|CDD|376618
NZ_CP016594.1|WP_068884361.1|722053_725740_-|non-ribosomal-peptide-synthetase	unknown	unknown	gnl|CDD|341279
NZ_CP016594.1|WP_004019729.1|707719_707968_+|acyl-carrier-protein	unknown	unknown	gnl|CDD|180304
NZ_CP016594.1|WP_004019732.1|710619_711468_+|hypothetical-protein	unknown	unknown	gnl|CDD|236090
NZ_CP016594.1|WP_004019730.1|707982_709164_+|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl|CDD|173838
NZ_CP016594.1|WP_004019740.1|721386_721995_-|acetyltransferase	unknown	unknown	gnl|CDD|379237
NZ_CP016594.1|WP_004019726.1|704157_704505_+|N-acetyltransferase	unknown	unknown	gnl|CDD|379642
NZ_CP016594.1|WP_004019731.1|709204_710512_+|diacylglycerol-acyltransferase	unknown	unknown	gnl|CDD|274360
NZ_CP016594.1|WP_004022807.1|726116_727766_+|long-chain-fatty-acid--ACP-ligase-MbtM	unknown	unknown	gnl|CDD|180289
NZ_CP016594.1|WP_004022808.1|727870_728617_+|siderophore-interacting-protein	unknown	unknown	gnl|CDD|99790
NZ_CP016594.1|WP_004022809.1|728824_729613_-|exodeoxyribonuclease-III	unknown	unknown	gnl|CDD|197320
NZ_CP016594.1|WP_004019724.1|701164_702817_+|ABC-transporter-family-substrate-binding-protein	unknown	unknown	gnl|CDD|173866
NZ_CP016594.1|WP_004019725.1|702838_703756_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl|CDD|180561
NZ_CP016594.1|WP_004019733.1|711532_712507_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|223687
NZ_CP016594.1|WP_004019728.1|706333_707674_+|salicylate-synthase	unknown	unknown	gnl|CDD|169151
NZ_CP016594.1|WP_004019739.1|719567_721382_-|siderophore-biosynthesis-protein	unknown	unknown	gnl|CDD|226715
NZ_CP016594.1|WP_004019735.1|714137_715682_-|pyridoxal-dependent-decarboxylase	unknown	unknown	gnl|CDD|99743
NZ_CP016594.1|WP_004019727.1|704518_706177_-|AMP-binding-protein	unknown	unknown	gnl|CDD|341244

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016594.1|WP_033206180.1|712821_714141_-|SidA/IucD/PvdA-family-monooxygenase	gnl|CDD|226017	COG3486, IucD, Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	1.38663e-147
NZ_CP016594.1|WP_004019736.1|715732_717235_-|peptide-synthetase	gnl|CDD|380462	cd19539, SgcC5_NRPS-like, SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- bond forming activity and similar C-domains of modular NRPSs. SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. This subfamily also includes similar C-domains of modular NRPSs such as Penicillium chrysogenum N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase PCBAB. Condensation (C) domains of NRPSs normally catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.	1.94078e-17
NZ_CP016594.1|WP_110117463.1|717222_719562_-|penicillin-acylase-family-protein	gnl|CDD|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	2.03851e-140
NZ_CP016594.1|WP_068884361.1|722053_725740_-|non-ribosomal-peptide-synthetase	gnl|CDD|341279	cd12114, A_NRPS_TlmIV_like, The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.	6.22515e-172
NZ_CP016594.1|WP_004019729.1|707719_707968_+|acyl-carrier-protein	gnl|CDD|180304	PRK05883, PRK05883, acyl carrier protein; Validated.	2.75096e-23
NZ_CP016594.1|WP_004019732.1|710619_711468_+|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.82734e-06
NZ_CP016594.1|WP_004019730.1|707982_709164_+|acyl-CoA/acyl-ACP-dehydrogenase	gnl|CDD|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	5.17525e-50
NZ_CP016594.1|WP_004019740.1|721386_721995_-|acetyltransferase	gnl|CDD|379237	pfam13523, Acetyltransf_8, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	8.35872e-38
NZ_CP016594.1|WP_004019726.1|704157_704505_+|N-acetyltransferase	gnl|CDD|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	1.8554e-18
NZ_CP016594.1|WP_004019731.1|709204_710512_+|diacylglycerol-acyltransferase	gnl|CDD|274360	TIGR02946, Putative_diacyglycerol_O-acyltransferase_Mb3115, acyltransferase, WS/DGAT/MGAT. This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity].	1.56182e-23
NZ_CP016594.1|WP_004022807.1|726116_727766_+|long-chain-fatty-acid--ACP-ligase-MbtM	gnl|CDD|180289	PRK05851, PRK05851, long-chain-fatty acid--ACP ligase MbtM.	0
NZ_CP016594.1|WP_004022808.1|727870_728617_+|siderophore-interacting-protein	gnl|CDD|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.86357e-49
NZ_CP016594.1|WP_004022809.1|728824_729613_-|exodeoxyribonuclease-III	gnl|CDD|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	4.39912e-106
NZ_CP016594.1|WP_004019724.1|701164_702817_+|ABC-transporter-family-substrate-binding-protein	gnl|CDD|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.43896e-148
NZ_CP016594.1|WP_004019725.1|702838_703756_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl|CDD|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	6.85129e-137
NZ_CP016594.1|WP_004019733.1|711532_712507_+|ABC-transporter-substrate-binding-protein	gnl|CDD|223687	COG0614, FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism].	6.75295e-40
NZ_CP016594.1|WP_004019728.1|706333_707674_+|salicylate-synthase	gnl|CDD|169151	PRK07912, PRK07912, salicylate synthase.	9.6583e-158
NZ_CP016594.1|WP_004019739.1|719567_721382_-|siderophore-biosynthesis-protein	gnl|CDD|226715	COG4264, RhbC, Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism].	2.60476e-147
NZ_CP016594.1|WP_004019735.1|714137_715682_-|pyridoxal-dependent-decarboxylase	gnl|CDD|99743	cd06450, DOPA_deC_like, DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.	2.26699e-87
NZ_CP016594.1|WP_004019727.1|704518_706177_-|AMP-binding-protein	gnl|CDD|341244	cd05920, 23DHB-AMP_lg, 2,3-dihydroxybenzoate-AMP ligase. 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.	0

Protein sequences

>NZ_CP016594.1|WP_004019733.1|711532_712507_+|ABC-transporter-substrate-binding-protein
MTSRHRLGALVASALLFAGLLAGCSSSDDESAGGSVQLNLPDGRQVTIPDTPERIVTLGDQWTDVVLSFGETPVGYYDYSKSATGEMQPWYGQKLADATFVDPTKGDDATTIATLNPDLIFAPGFASDSPEFEQISKLAPTVNAISDQEIDPWQDMVTVMGTVLHDPEKAKSIIDDTNGKIAAVSEEYPGLKGKTYAFAFMYGPDQLSVLGDENDGAGKLFTQLGMKMAPKLVAEYQRTGQPRFGLSTENIPMLDADVLVVATATPEQAETLRSLPGYKNLKAVKDNAVTFMTQSQITGLNAPTPNSIPYVLDLLKPSFAAASN
>NZ_CP016594.1|WP_004019732.1|710619_711468_+|hypothetical-protein
MSNDVNYQDPSAVDYQSGVDYREPDAGSSRRSGGVSIPTVLASAGVAAIISAIVVTIGVVGIVVSERNDSATAAQPTVVNLGAAQTALPQQGIAGQQPGAVPGQPAPAGAPAAGAPAAAPTENVPEGGGAIGGPVGPPGEGAGQAPAPAPAPGTTAAPQQTVAAGPTALTPGQLNTKVRIVMNSNGSRAARAAELEGGERALRQIDLVARAITTYGNVGLSYQMVGPVQVSGNTLTAPLQISVVGRGSQNRSMTFVWSGNKWKLSNRSVCTIAGFVLLPCSL
>NZ_CP016594.1|WP_004019731.1|709204_710512_+|diacylglycerol-acyltransferase
MNSPAGQAPVDARVTELAPPDHTYLHMDKAGAPMHWSMILQLEGGGDVLGLDAVRERVRERSGLFEIFRLGIRNGRWRKPEVVLADDSWDAGEHVTELGFTDRAHLQRRVAKLLESPLPRPRPFWDITLFTPSAGAEGVGQWVLLRVHHSVSDGIAGAAFAALLADGEPEDLAEFERFATSPRFRISGIDPEELAEAKAAYGDQHAAGGGKKRAWPALTKSGEREYALVDASTRDLRKAAKRNDATVHEFLLAAIGRAISLNPPTSPQADVVRVTLPVTLDDGFRHTGNAVSVALLNLLGNEPDLTRQIDRARSELETIARRKPELYLAAADDLPRAPLWGLQRAIVNASMSHMHPDIHIGINPGFSRVRSVLGQSIVTLTPLSPLAGYSLSVTTLILGHTTTFGVVTDAQALPGYADRFVATLGEVLREALPST
>NZ_CP016594.1|WP_004019730.1|707982_709164_+|acyl-CoA/acyl-ACP-dehydrogenase
MSVDTPVQTYAELLDAAFDERVTSWTAQAEQDHRFPRPLLEHLGSEGVFVRKWEDRKFTDLHDHFALGAHLGALGSAAIGVGVSLHDSAIAILRRFGRNDYLKDLAQRALTAETVLCIGASEEQGGSDLQNSETRIFPENDGFRVVGHKKFVSLSPIADHVFVVCRGVDDGPDLGGNVALAAVPIESVTVGEPYQKLGAGPLDTAPVTIDAWIPEEALIARPGTGLAIISWGLAHERYSVAAQIAAACEVMIGVTLARMMERTQFGKKLYDHQALRLRVADLQARVDVLRYALAGVAAEGKINLRTAAALKATAANLGEEVASECLHIFGGIGYLETETPIGRWWRDMKLARVGGGTDEVLWELVAAAMKPDTERYQAMFIDSELHRPGSSAS
>NZ_CP016594.1|WP_004019729.1|707719_707968_+|acyl-carrier-protein
MSDHITEALRGILEEDLDLSLGDVSRDAKLIDDLGLDSVAFAIGVVAIEERLGVKLSERELFESKTVGDLEDLIRSKAGTPA
>NZ_CP016594.1|WP_004019728.1|706333_707674_+|salicylate-synthase
MSLTTESHAAQFVDLLAPASPLGESDAARITAAWAGSGEFGDHVVYERDRRWTFAAGVRARVVVTRSEVIVDDQGDRTTTPWRGDPADALAAATASLSIPDWRVYGWVGFDFCAPYHGILDRVPEDTVLAHLIVPEFEVTVDAEGVDTGAVDADRARRLLEIASQATVSAESRPVDVQADPDDYRGRVATAVAEIEAGRYQKVILSRAVDIPFDVDIPATYARGRADNNPARSYLLSLGDLQAAGFSPELVVAVHDDRTVVTEPLAGTRAFGISADQDAAARADLLSDAKEIAEHAMSVRACFDEISSIAADDTTAVSEFMEVRERGSVQHLASTVRGTLAAHESPWRALEVVFPSITASGIPKTPAVEAIDRLEPRRRGLYSGAILTAASTGELEATLALRTIFSSGDGAWLRAGAGIVAQSTPEREFTETCEKLGSVAPYVVPR
>NZ_CP016594.1|WP_004019727.1|704518_706177_-|AMP-binding-protein
MPTHLDHVTDLLDGFSPHTDAQAQRYRDAGVFLGRPLFAALDVAAERSPDAPAVTDASADGPRTLTYAEFRAATLRRAAGFVDAGLRPAQRVVLQLNNSLDFAVTLFGLLRAGVVPVMTLPAHRITEIAHLATGSGAVAYIGEDDRRGFDFRDLAAELQSRVPDVAQVFISGDPGRFAALPDADPAATALPDGPDPGLPALFLVSGGTTGLPKLIARTHDDYDLNARLSAGIAGLTADDTYLVALPAAHNFPLSCPGILGVVGVGGHIVFADNPSPDNTFDLIERHRITVTSLVPALAQLWCAATEWEPADISSLRLLQVGGAKLAQPDAVALDAALGPVAQQVFGMAEGLICYTRLDEPRELVHQVQGSPMSELDEVRVVDEDGDDVPDGTEGELLVRGPYTIRGYYRAAAHNEKSFTPDGFYRSGDKVTRLPSGHLAVTGRIKDTIVRAGENVAADDVEENLLAHDSVRQVAVVGLPDDALGEKICAAVVLSHEHPPAQPLELATIRTFLAERGLASFKLPDAVRIVTTLPVTAVGKIDKKVLRETLLAD
>NZ_CP016594.1|WP_004019726.1|704157_704505_+|N-acetyltransferase
MLRKHRQRPPQSAKSILQQISQVVHNPDRDRFELWVAGDLVGVLGYTTETADGQTTITVLHTVLYDEYSGHGLATRLTRTVVHYTREQGARLRPVCTFTKRYLDSHPGIVTLAPV
>NZ_CP016594.1|WP_004019725.1|702838_703756_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MRTVDAEQRTVDGHRRTLDEGFVELPVAQPGSAPVRVLTIAGSDSGGGAGIQADMRTFALLGVHGCVAVTAVTVQNSLGVSGFEEISPQTVAAQIDSVAGDIGVAAAKTGMLASAPIIEAIVEQCGASGIGRDASVPLVVDPVCASMHGNQLLADSALDTLRHKLFPLATVVTPNLDEVRLITGIEVTDADSQRDAARALLDLGPRWALVKGGHLRTSDRSPDLLYDGDQFIELSHERIDTPHDHGAGDTLAAAIASALAHGYPVPEAVGFGKGWVTRCLAAAYPLGAGHGPVNPLWRLSAGPAD
>NZ_CP016594.1|WP_004019724.1|701164_702817_+|ABC-transporter-family-substrate-binding-protein
MRHFWILLSVVVIAVGSVAGCGAALDTSAVTTDGASLNPQPRENLRDGGSLTTAITEVSAQWNTFHADASAYTLALWRWYNPNLAYFSPDGEYSPNPDYLTDVRTETVDGDTVVTYTINPRAFFNDGTPIDYRAFVETWRTSRGIDDRYIVSSTDGYSQIGSVTRGIDDRQAVVRFDGVYAWPDGLFNLVLHPKATSPDTYNKGYVTNPHPEWGAGPYTIASYDPNAGTVVFERNPKWWGKPGKLDRRVFRQLESQAALNAFQNGEIDVAGVAAKDARARVLTMNGIDIRTAASPQQALLALNLDAPILADRTVREAVMTAIDRETLARIRFTGLNYTEELPGSLSLYPFQPGYRDNLAGVVSYDPDRASGLLDQAGWRIGDDGIRTQDGARLSLTLPNVGDDTTSANLSRALQAILGKVGIDLVVTQRPSSDFSKVVVNKEFDLFMMGFSSSDPFGMAYFCQVWCSDSQFNPAGAGTPELDAQIEAMSQIGDPTAQIAAGNRVEHEAFQQFSNLPLFNGPAMVAVKEGLANYGAGQFYIGPIEDIGWEK
>NZ_CP016594.1|WP_033206180.1|712821_714141_-|SidA/IucD/PvdA-family-monooxygenase
MNSVENVDVLAIGCGPFNLGLAALASTLDDVNLLVVDSRDEFRWHPGLMFDDATLQVSFLSDLVTLVDPTHPLSFLNYMADVDRMYRFLVREDFFPTRIEYEAYLLWCVSRLDSLRWSTTVDEVTWDAEADAFRVTMHTPTSSSTVIARHVVVGIGTEPFIPQALSSESPAVVHSSDYLFNQEKALAADTVTVVGSGQSGAEIVIDLLEANLRGGPAVRWWTRTPWFAPLDFTKLSLEMTTPAYMDYFHSLPEAARDRVRPQHWQFHKGISTDSLERLHDLLYRRQLQDKLNPVQLRISVEVDGVDTLADGKLRVRGRHLDTGSELAHTTDMVIASTGYQARKADFLAPIESALHRDSRGRLVIGANHEIETDDALTNRIFVANAEEHAHGVSAPNLDIGAVRNARILNTVLGREAYRLPKHTAFTSFGAADDDDIVAP
>NZ_CP016594.1|WP_004019735.1|714137_715682_-|pyridoxal-dependent-decarboxylase
MSEDHQSVWGASRFARPGHGWADVGRGLTEVAAAVSDDHHGAPLPSGDPVAVLGGVTALLGPHGIPETGIGESEALTRLARLVAEFGLDLTHPMAAAHLQPAPLSVAVAADALASATNASLDTYDSGPATLALETWTVQSLARMAGFGEHAGGVFSPGGSISNLLALMIARDHTAARHGVDVRHHGVGALHRPVVFCSRVAHFSVHRACAALGLGESAVIPVDVDSHHRMIPEALEAAIRDSGTATPLAIVATAGTTDFGTVDPLGEIADIAERHEIWMHVDAAYGFGSLFSDRLAGLLAGVERADSVTLDLHKVGWQPAAASLMLLSDADRFVSLNRSVAYLNPDDDVEAGYSGLLGQTLQTTRRPDVLKVATTLLAYGRSTLGEMLDKCNDLALYAEQRVATELQLELIAPVTLTTVVFRYRCTDLDAVNGELRRRLIADGKALIGRTQVRIPGEDEPQTCLKLTLLNPETSESDIDELFDELLRVALEVESEGTAAPGAGTYSEEMVRVSE
>NZ_CP016594.1|WP_004019736.1|715732_717235_-|peptide-synthetase
MPALTEARLTLLRRRLAQAGDIRPAPGAGDLRPARSAPGAGDTRPEATVPFGEFGIAERRMWRIYELDPESLSHNIGLVLEFGGRRTLGSVVAAAELLVDRFRVVRSVVEVDDAGTPSRREVPRAGSWDASRSVWTWGPTDSAVSDAGDDVDATATALTRTPFDLHSEVPLRMRVSGSDGNVTMILVVHHLAVDDTSWPLLLGTLVSGSWPGDVTADARPETPDPAAAAEAANSAVRHAIATWAADDVRYPLTGELPTESAADSWLSPMDDRDGIKAAAPVAADSLSAFGRVAQTVGATPNALLIGVCSLASYALTGAADHVLVVPADNRRREQAPQDVGYCGNIIPMRFRVDPDATVEQALREAGSVIYRSMEHSGTDFGPVLTALRQQGGRFPVIEIMASVRPAPLRGIPQPADAPVTCRSVFNGIANYPLSIAFEADDDSTHVEVDHQPGIVPDEMADRATAVLTTLVDLIPTSLHHSVSALLEILAERVPQKGTAG
>NZ_CP016594.1|WP_110117463.1|717222_719562_-|penicillin-acylase-family-protein
MTATHSGAGPDVEILRDGHGIPHVRGADPAAVLYGQGRACGEDRRWQIEFMRLRAEGRTAEVFGASCVEWDTFARRAQLDAAARRIFDASSARTRDLVAAYAAGVNSTLDDPDTSAAAPELEALAHRPQPWRPWTPISVFIMHHVLFGRFTTKLFRLHACRTLGLDALRFWDFETRETDPTMPAMPDEAFLDEILAITRPVSPEQPSPAVDLGDPMSGSNAWGVSAERSSTGAPIVAGDPHRFLELPGIYQQFHLASTGPLDAFDMAGFAFAGVPGVPHFCQGDDIAWGITNAMGDYQDLFLERLTRDETGTLLVEVPGGSRVPARVSTETILVRGAEPVATQVITTPNGAVVFGGPEDSFAMSIRSPLLSEDVSFDAPLDLLFASTVADVEAALVNWVEPVNRAVIAHADGTVATHVAGRVPVRAPENYWLPVPGWDERYQWRGYERGSLGDPDFDATLRSTGITVTANQRMSDVPALQPLTSECVEPFRADRIAARLDDLDSVSPADCADIHSDVRLEQATVVQELLSRVRADNAAAEDVRQRLVAWDRSMAADSTDAYLYAEFRTQLVLGVANTDILAPLRGPHGFPAVFQPWFVPEPRLATALTSVVANTAGIGIDIEAVAVAALDAVVARVAGFGSTPTWGSVHRLAPIHGFDLVGASPQYPDLFATLRPTPLPLAGDAESVFANAAAVGTHLCITGAAARYVWDLADRSASRWIVPLGVSGDPRSEHFQDQAAQWATGELVEVVRDWDTLHAMAAAASTPTAATSTEREPCPR
>NZ_CP016594.1|WP_004019739.1|719567_721382_-|siderophore-biosynthesis-protein
MTLQDIGTIQEFATRTAGGSGARSHRQTYHTRIATKILAEFSHERALHPVASGDGYVVSSADGLTDYHFRADRLALDSWAIDESSLRRVRGGDELPIDAVAMIVDLAPFLGIGPQALPEYLEEFINTLAISADRPDERRIPATDLAHADFQTIEATMTEGHPCIVANAGRLGFSSEDIERYAPEVGNHFRLVWLAARREDCDVATVSDIDYDTLLVDELGAETVAGFDSALREAGCDPADYRYLPVHPWQWVEKVRKLYSADIAGRRIVEVGTSPDLYQAQQSIRTVFNSTTPTRNYVKVALSIVNMGFTRGMSADYMRTTPLINNWVRGLVADDQYLAAIGFEMIFEVAAIGYRSPTFTPITQPGSEYRKILSALWRQSPVPLTAADEQLSTMAALLHVDHLGEPLVGAFIERSGVPATEWIRRYLRTYLHPIAYLLYRYELKFSPHGENLILVLADGIPVRAILKDIGEEVSVFGEAQGLPESCARVRTTEPDEIRNLGVLSDVFDDFLRPLAAVLHTHGIVDDGEFWSLVGESLHEFVAAHPELEDRFTRWDLFAPEFGAVHMNGLQLRNNKRMVDIEDSYASLIDAGHRLANPIASQRGR
>NZ_CP016594.1|WP_004019740.1|721386_721995_-|acetyltransferase
MTISSAPTYDLNSVDLDDVSHAATVHEWLTHPKAKYWDMLDSSVTDVEKMIRDSAEATAGTPYGMRLGYHDGRPQFLFELYDPAASELADPASGYVPADGDIGMHLLVAHAEQALPGFTGAVMLHIMRTAILEVGAARVVVEPDVRNKAVHRLNASVGFRVDGDYPVGNKTAHLSYCTRADFLAVTDNGKSVGPVEVTDLGA
>NZ_CP016594.1|WP_068884361.1|722053_725740_-|non-ribosomal-peptide-synthetase
MATNSQTTDLATMADIVAEVAGALGLTPESIDPEQDLIAQGLDSLRMMRLAGTWRKRGIDIDFARLAAQPTITAWAPLLLAATGDAEVDTTTPDIRAEVGTALGVSPESLDPDQDLIAQGLDSLRMMRLAGTWRKRGIDIDFARLAAQPTITAWAALLGGASAPIADDDSSSPVSEATTGPFPLAPMQHAYWIGRSDSHAFGNVAAHLYIEFDGSDVDPERFAAAMSALMERHPMLRVRVLPDGTQEIGPAHPEAIAVHDLRSHSAEMVEQILAAKRADGTHRTLPVDEGAVIRAELSLLPANSARVHLDVDMIAADAMSYRVLVDDFARLYRGETLPELGVTFATITADRTSREILDDDVTWWRERIPTLPGPPELPLDERAARGEVEPHSVRLHHSVSASDWKRLEEHAHRRGVTPAAAVAAVFAEAVGTHSATPCFLITVPLFDRPQVHPDVERVVGDFTSSILVGVDLSAPATLAERARSMRSSMHEAAAHGSMSGLDVLRELSRHRGEPVVSPIVFTSALGLGDLFSQQATDVLGDPSWIVSQGPQVLLDAQVTEVAGGLLLNWDVRASDLRLSTARSMFDHYVRLLGLLVDGEWDAPAPSPISAEVRAQRLSVEGPLPVTDTFDGTLHGTFFARAAEHDDAPAVVSDARTWTHAELAEEARRVAGALVAAGVASGDTVIVHLPKGGDQVVAALGVLAAGAAYVPIAPTQPRARRERILDVATPAAVLTTDPAAWEPTAGTVLTLDDARLAEPTEPIAVATDDLAYVLFTSGSTGLPKGVQVPHRAAVATITDLVDRYAIGAGDRSLQVSSLEFDLSVFDIFGLLTVGGAVVVPGDDEQTKVDDWVRLLGEQSVSVLNCVPSILGMLLDLAPLPSSLRMIIMGGDKVDVSLLDRVAAQLPDCRVAGLGGTTETAIHSTICEADAVPAGMAFVPYGIPLRGVRCRIVDDAGRDRPDLVPGELWIGGAGVADGYRGDPERTADRFVEHEGQRWYRTGDLARYLPGGFLDFLGRADHMVKIRGYRVELGEVEAGLLGLNGVGSAVAWSDGRDLRAAVVLTAGATDDDAGLRARLTETLPPHMVPRSVAVLDRFPLTPNGKHDRKAIAAGTDTDDDPLEAVTPRGPVEEALAVIFGEVLPAPPASVTEDFISLGGDSVQATRVVALVRQWLDAPGLSVADIFTQRTIAGLAGRLTELGGERASFVAQTFLDVIHLTDEQVEAEIARS
>NZ_CP016594.1|WP_004022807.1|726116_727766_+|long-chain-fatty-acid--ACP-ligase-MbtM
MSQNSVILEESGSTNALAATVREAMLAGDTSLSVLDSDTGEWVTAPWREVHARAEQIAVQLLADSELHEPQALGLIGDPTVDLIAAIQGAWLAGVPVTILPGPIRGADEERWAQNTYQRYVSIGVGTVLGSGTQLDLLTKVEGRLHIARVAEYGLGADTTDFVARNVNGNTIAVLQGTAGSTGDPKTVALTASAVYSNAIELVSRLGLHRTRDTGFSWLPLYHDMGLMFLLAGMTTGIPAYIVPNTAFAAAPFKWMQWLTETKTTVTAAPNFAYDILGRYGKLLRDIDLSNLRVAISGGEPIDADAFDKFLEATAPFGFDRSAAAPAYGMAESACAVTMPAVGEGVHYDEVTVTPPGGGEPIRRRYAILGKPLGGMQVRIVEPNVDVPVIDGRNVGHVEIRGASMMRGYLGDADLGAGEWFSTGDLGYLVDDRLVICGRAKEVIIVAGRNLFPIEIERAAAEVAGVRRGGVVAMARGEGSSRPGLVILAEYKGSDPDTARAEVNSEVASACGIMPAEVIFVAPDSVPRTTSGKIRRLETRQMVENGTFE
>NZ_CP016594.1|WP_004022808.1|727870_728617_+|siderophore-interacting-protein
MSEVSTKGRGWQGAVMKILGGDDFTFTVTAKESVTDHYLRLHFDGGGLLADSTVHPTMWVRLWFADGGKMHQRGYTLVDPDPSTDTFDIEFAIHDGTAARWARDAQAGDTIGATLMGSKFAIPEPAPVGWLIAGDTASLPAINSLLDTLGNSGAGATIWFEYQHESDKSLPLRLRDHDTVHWIARGADGGALVDAVRSAAFDATDHFGWVALDSVSTRAVAGSFKADFGLPKKSVKSQAYWIVGKSFA
>NZ_CP016594.1|WP_004022809.1|728824_729613_-|exodeoxyribonuclease-III
MRIATWNVNSIRARSESVVAWAEGADVDVLALQETKCHDDAFPLMSFLAAGYDVAHVGQGAYNGVAIASRVGLDEVEIAFDGVPTHPVDGQPIREARSISARCNGVRVWSLYVPNGRTPDDPHYSYKLAWLDALRNHITLRLAHDPAAELMLAGDWNVAQTDDDVWDREYFDGRTHVTPPERAAVQGFLDAGLVDSALPYAPGFTFWDYTQLRFPRNEGMRIDYAFCSPALDTRIMGAHIGRDARKAKGASDHAPVVFEVAE

Crispr_ID: NZ_CP016594_2

• CRISPR_ID: NZ_CP016594_2
• CRISPR_location: 1200229-1200323
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016594_2

Consensus_repeat	Method
CCGAGACCCCGGCCCGGCCCGAG	CRISPRCasFinder

spacers of NZ_CP016594_2

>2.1|1200252|49|NZ_CP016594|CRISPRCasFinder
CCGGCCGCCCAACCCGGATCGACCGCCACGCCGGACTCAGCTGCCGAGC

CRISPR arrays and Neighbor proteins around NZ_CP016594_2

CRISPR arrays

The CRISPR arrays of NZ_CP016594_2

>merge|NZ_CP016594|2|1200229-1200323|CRISPRCasFinder
CCGAGACCCCGGCCCGGCCCGAGCCGGCCGCCCAACCCGGATCGACCGCCACGCCGGACTCAGCTGCCGAGCCGAAGACCCCGGCCCGGCCCGAG

>NZ_CP016594|2|2|1200229-1200323|CRISPRCasFinder
CCGAGACCCCGGCCCGGCCCGAG	CCGGCCGCCCAACCCGGATCGACCGCCACGCCGGACTCAGCTGCCGAGC
CGAAGACCCCGGCCCGGCCCGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016594.1|WP_004019964.1|1203618_1204479_+|pyrroline-5-carboxylate-reductase	unknown	unknown	gnl|CDD|237008
NZ_CP016594.1|WP_004019975.1|1194694_1195441_+|phosphoglyceromutase	unknown	unknown	gnl|CDD|184519
NZ_CP016594.1|WP_033205326.1|1191420_1193028_+|4-coumarate--CoA-ligase-family-protein	unknown	unknown	gnl|CDD|341230
NZ_CP016594.1|WP_004019970.1|1197373_1198060_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NZ_CP016594.1|WP_033205321.1|1201822_1202716_+|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl|CDD|224007
NZ_CP016594.1|WP_004019969.1|1198087_1198948_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004019976.1|1193094_1194543_-|APC-family-permease	unknown	unknown	gnl|CDD|223605
NZ_CP016594.1|WP_004019963.1|1204667_1204901_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|200128
NZ_CP016594.1|WP_004020514.1|1190724_1191339_+|YbjN-domain-containing-protein	unknown	unknown	gnl|CDD|371210
NZ_CP016594.1|WP_033205387.1|1209377_1211042_+|HNH-endonuclease	unknown	unknown	gnl|CDD|367155
NZ_CP016594.1|WP_004019962.1|1205425_1206478_+|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|187551
NZ_CP016594.1|WP_004019968.1|1199024_1199981_+|Ppx/GppA-family-phosphatase	unknown	unknown	gnl|CDD|223326
NZ_CP016594.1|WP_004019965.1|1202754_1203612_+|thioesterase-family-protein	unknown	unknown	gnl|CDD|379298
NZ_CP016594.1|WP_004019960.1|1207876_1209040_+|zinc-binding-dehydrogenase	unknown	unknown	gnl|CDD|176223
NZ_CP016594.1|WP_004019958.1|1211063_1213430_-|pyruvate-dehydrogenase-E1	unknown	unknown	gnl|CDD|225329
NZ_CP016594.1|WP_004019961.1|1206889_1207837_+|acyltransferase-family-protein	unknown	unknown	gnl|CDD|153249
NZ_CP016594.1|WP_004019974.1|1195522_1195843_+|N-acetyltransferase	unknown	unknown	gnl|CDD|379642
NZ_CP016594.1|WP_033205390.1|1189353_1190703_+|D-inositol-3-phosphate-glycosyltransferase	unknown	unknown	gnl|CDD|132490
NZ_CP016594.1|WP_003402602.1|1205226_1205328_+|AURKAIP1/COX24-domain-containing-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004020516.1|1188269_1189226_-|zinc-ABC-transporter-solute-binding-protein	unknown	unknown	gnl|CDD|238502

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016594.1|WP_004019964.1|1203618_1204479_+|pyrroline-5-carboxylate-reductase	gnl|CDD|237008	PRK11880, PRK11880, pyrroline-5-carboxylate reductase; Reviewed.	1.94353e-95
NZ_CP016594.1|WP_004019975.1|1194694_1195441_+|phosphoglyceromutase	gnl|CDD|184519	PRK14120, gpmA, phosphoglyceromutase; Provisional.	0
NZ_CP016594.1|WP_033205326.1|1191420_1193028_+|4-coumarate--CoA-ligase-family-protein	gnl|CDD|341230	cd05904, 4CL, 4-Coumarate-CoA Ligase (4CL). 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.	0
NZ_CP016594.1|WP_004019970.1|1197373_1198060_+|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	8.71955e-94
NZ_CP016594.1|WP_033205321.1|1201822_1202716_+|sugar-phosphate-isomerase/epimerase	gnl|CDD|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	5.03861e-25
NZ_CP016594.1|WP_004019976.1|1193094_1194543_-|APC-family-permease	gnl|CDD|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.91208e-42
NZ_CP016594.1|WP_004019963.1|1204667_1204901_+|helix-turn-helix-domain-containing-protein	gnl|CDD|200128	TIGR01764, Probable_excisionase, DNA binding domain, excisionase family. An excisionase, or Xis protein, is a small protein that binds and promotes excisive recombination; it is not enzymatically active. This model represents a number of putative excisionases and related proteins from temperate phage, plasmids, and transposons, as well as DNA binding domains of other proteins, such as a DNA modification methylase. This model identifies mostly small proteins and N-terminal regions of large proteins, but some proteins appear to have two copies. This domain appears similar, in both sequence and predicted secondary structure (PSIPRED) to the MerR family of transcriptional regulators (pfam00376). [Unknown function, General].	5.08444e-18
NZ_CP016594.1|WP_004020514.1|1190724_1191339_+|YbjN-domain-containing-protein	gnl|CDD|371210	pfam10722, YbjN, Putative bacterial sensory transduction regulator. YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabilizer for some other unstable proteins. This family was expanded to subsume other related families: DUF1790, DUF1821 and DUF2596.	5.12429e-21
NZ_CP016594.1|WP_004019962.1|1205425_1206478_+|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.0859e-70
NZ_CP016594.1|WP_004019968.1|1199024_1199981_+|Ppx/GppA-family-phosphatase	gnl|CDD|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	7.1825e-92
NZ_CP016594.1|WP_004019965.1|1202754_1203612_+|thioesterase-family-protein	gnl|CDD|379298	pfam13622, 4HBT_3, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	1.01801e-38
NZ_CP016594.1|WP_004019960.1|1207876_1209040_+|zinc-binding-dehydrogenase	gnl|CDD|176223	cd08262, Zn_ADH8, Alcohol dehydrogenases of the MDR family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	1.16389e-141
NZ_CP016594.1|WP_004019958.1|1211063_1213430_-|pyruvate-dehydrogenase-E1	gnl|CDD|225329	COG2609, AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion].	1.76367e-146
NZ_CP016594.1|WP_004019961.1|1206889_1207837_+|acyltransferase-family-protein	gnl|CDD|153249	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.	1.29407e-43
NZ_CP016594.1|WP_004019974.1|1195522_1195843_+|N-acetyltransferase	gnl|CDD|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	5.64018e-26
NZ_CP016594.1|WP_033205390.1|1189353_1190703_+|D-inositol-3-phosphate-glycosyltransferase	gnl|CDD|132490	TIGR03449, mycothiol_MshA, D-inositol-3-phosphate glycosyltransferase. Members of this protein family, found exclusively in the Actinobacteria, are MshA, the glycosyltransferase of mycothiol biosynthesis. Mycothiol replaces glutathione in these species.	0
NZ_CP016594.1|WP_033205387.1|1209377_1211042_+|HNH-endonuclease	gnl|CDD|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	1.12675e-22
NZ_CP016594.1|WP_004020516.1|1188269_1189226_-|zinc-ABC-transporter-solute-binding-protein	gnl|CDD|238502	cd01020, TroA_b, Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	3.72249e-71

Protein sequences

>NZ_CP016594.1|WP_004019968.1|1199024_1199981_+|Ppx/GppA-family-phosphatase
MGSNTVHLLVVDAHRGGHPTPMSSTKAVLRLAEQIDVDGRMSDRAVAKLIDSIDEFTHIARTSGCEQMMAFATSAVRDATNSDDLLDEIEQRTGVRVLVLSGRDEARLTSLAVRRWRGWSAGRILALDIGGGSLEMSNGVDEEPDVALSLPLGAGRLTREWLPDDPPDRRRVGVLRDWLDAELRAPAAQLLAPGAPDLCVGTSKTFRSLARLTGAAPSSAGPRVRRELTTSGLRQLISFISRMTKADRAELEGVSSDRAGQLVAGALVAEAAMRALQVDTLEICPWALREGVILRRLDAEQADSLEPTPARGVHEGVG
>NZ_CP016594.1|WP_004019969.1|1198087_1198948_-|hypothetical-protein
MTAISPSAPRIDPAPEVELDFPREWYEFADPADPEHVIRADLTWLLSHWTCVFGTPACQGILPGRETDGCCSHGAYLSDDDDRETLARGVAMLTPADWQFHKKGSGKDPVGPKGYLEESDLDDEPALKTRLHKGACIFLNRPGFAGGVGCALHSMALRKGLEPLTVKPDVCWQLPVRREQDWVERPDGTQVLQTTITEFDRRGWGEGGHDLKWYCSGSPDAHIGAKQVWESYAPELTALLGEAAYEALAAACRRRNGLGLIAIHPATQAATRRRDTDVKYELQPPE
>NZ_CP016594.1|WP_004019970.1|1197373_1198060_+|response-regulator-transcription-factor
MTHVLIVEDEESLADPLAFLLRKEGFEASVITDGAQALSTFDRVSPDIVLLDLMLPGMSGTEICKALRTRSNVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARIRAVLRRGGDVPDDGLEIGILEAGPVRMDVERHTVAVNGTPITLPLKEFDLLEYLLRNAGRVLTRGQLIDRVWGVDYVGDTKTLDVHVKRLRSKIEPDPANPKHLITVRGLGYKLEA
>NZ_CP016594.1|WP_004019974.1|1195522_1195843_+|N-acetyltransferase
MADVGNLRIEHSPARERYEAILVAESSGEDEVVGYVDYVSEPYQVVVTHTVIREQFSGHGYAGQLVRAVLEDIRGSGKQVVPVCSYVQRFIERHPEFADMAVPVPQ
>NZ_CP016594.1|WP_004019975.1|1194694_1195441_+|phosphoglyceromutase
MSNGTLILMRHGESEWNASNQFTGWVDVALTEKGKAEAERGGELLVEHDLLPDVVYTSLLRRAITTAHIALDRADRLWIPVIRDWRLNERHYGALQGLNKAETKEKFGDEQFMLWRRSYDTPPPAIEPDAEYSQVGDARYADLAEVPLTECLKDVVDRFIPYYLETIVADVKAGKNVLLAAHGNSLRALVKHLDGISDDDIAGLNIPTGNPLRYDLDDDLKPLNPGGTYLDPEAAAAGAAAVAAQGQK
>NZ_CP016594.1|WP_004019976.1|1193094_1194543_-|APC-family-permease
MTASTDAGATGQNAEKQPELKRVLGWKLLLLFIIGDILGTGVYALTGQVAGEVGGAAWLPFLIAFAVATLTAFSYLELVTKYPQAAGAALYVHKAFGVHFITFIVLFTVMCSGITSATTASRAFAVNMLAAFSGDKPDATSPALFAIAIGFLLLVMFINFRGVAEGVGTNVVLTLVELTGLLLVLFIGYWFMVGGNADHWDAVVAFESPDDKNVFIAVTAATSLAFFALVGFEDSVNMAEECKEPTRIFPKVMLSGLGITAVVYVLIAICAVAIVPVGVLAESETPLVDVVQTAAPDFPMSDLLPWISMFAVANTALINMMMASRLLYGMAKQGVLPKFLAYVHPGRRTPFAAIVFTTVIALCLLTYVSADPEGSIVGLLGGTTALLLLAVFTVVNVSVLVLRKDKVGHNHFRTYTPIAVLGAVTCGYLTLPITGRDPEQYVVAGWLLLLGIVLWALTYWWNKRSGAAATSAYDDIPPHEIP
>NZ_CP016594.1|WP_033205326.1|1191420_1193028_+|4-coumarate--CoA-ligase-family-protein
MSFTSPFPDVEIPDVSVFEFLFGAVAEDDLGRTALVDPKSGATTTYAQLISQIDAAAGALASRGIGVGDVVGILSPNIPAFATVFHGVLRAGGTATTINALFTGPEIAKQLRDSGAKMLVTISPMLEQAKAAAAEVGLADADLIVLDGEGQDASGHPNAADLLGAGLSAPEVSFDPSTHVAVLPYSSGTTGNPKGVALSHRNLVANVAQIRPLQGMGADDVVIAVLPFFHIYGMTVLLNAALYNRASLVIMPRFDLVEFLENIQNHKVTMAYIAPPVAVALAKHPIIDNYDLSSLHTMMSGAAPLDDELGQAVAKRLDLHMLQGYGMSELSPVSHIIPADTPGLLGQQDPPLSSTGWAVPNSENKIVDPASGAEIELPSEGLSEPGELWVKGPNVMLGYLNNEQATADTIDADGYLHTGDMAQVDPTGCVYIVDRLKELIKYKGYQVPPAELEALLLTNDKIADAAVIGVIEAESGEEIPKAFVVRQPDADISAEEVIEFVASKVAPHKKVRAVEFIETIPKSASGKILRKDLRK
>NZ_CP016594.1|WP_004020514.1|1190724_1191339_+|YbjN-domain-containing-protein
MSRTEVVDLLEKTLGENEIAFTRKSGGGADVDHVVVELPGERKLKTTVLLTASEHGVRVEAFVCRRPDENHAGVYKHLLKRNRRLYGVAYTIDNTGDIYLVGRISADALSSGEVDRILGQVLEAADGDFNTLLELGFLTSIRREWAWRVSRGESLRNLLAFEHLIDKESLPEAGAPLEGRYVPGESVVEGADQATDVGSKSDES
>NZ_CP016594.1|WP_033205390.1|1189353_1190703_+|D-inositol-3-phosphate-glycosyltransferase
MTSSPFPRRVALISVHTSPLAQPGTGDAGGMNVYVWQTATRLARRGVEVEIFTRATSSADAPSVAAAPGVTVRNVVAGPFEGLDKRDLPAQLCAFTAGVLRAEAAQAPGHYDVIHSHYWLSGQVGWLARDRWGVPLVHTAHTLAAVKNASLAEGDTAEPQLRVIGEQQVVGEADRLVANTQTEAAELLSMYGAAADRIDVVTPGADLDCYTTGSASAARAALGLDPDETIVTFVGRIQPLKAPDLLVAAAAPLIRESAESGRKLRLLIVGGPSGSGLQRPTALMDQVAELGIADAVTFLPPQPADRLVQVYRASDVVAVPSHSESFGLVAIEAQACGTPVIAANVGGLGVAVDDGRTGVLVNGHGVGDWTNAIEKLLAQPERLVELGHNARSHAEQFSWEHTVDQLLESYGRAMRSFAAHRSPESPDPSATAGARVRRRWRRRRNRVTV
>NZ_CP016594.1|WP_004020516.1|1188269_1189226_-|zinc-ABC-transporter-solute-binding-protein
MKKSLLAAAGVLSAAALVLSACSSDSGGSDGPPTVVASTNVWGSVATAVAGDKAQVTALYNNADGDPHEFEPSAADTATIADADILVFNGGHYDSYMEEAAANSDATAVDAFALLGGDEHAEADHAEGDHSDGAHDHSHDDQNEHVFYDLPVVAQVADKVADALAEQDPANAETYRANAETFTTGIDGLRAKLTTIREQHAGTEVAQTEPLAGYMLTEAGLVDIAPAGFTQAVEEGQSPAAADRAALQDILADRRAKVLIYNTQAVDPVTQAMLDVAGSAGVPVVKFTETLPDGVTDYLVWQGAQIDALTAALGSGSN
>NZ_CP016594.1|WP_033205321.1|1201822_1202716_+|sugar-phosphate-isomerase/epimerase
MNPRPAAEIPIGLSTASVYPQNTEAAFAYAADLGFDGVELMVWGDSLSQDIRRVEYLSDHYQVPVLSIHAPCLLITQRVWGRDPVVKLARAVEAAEDLGASTVVVHPPFRWQRGYVAAFDDLVDELEADSGIAVAVENMFPMRADRLFGAGEPSVRRLTKRGGGPGLAASAFGKSIDPTDDGYAHYTLDLSHTATAGVDALALLDRMGSRLNHLHLADGHGAATDEHLIPGDGGQPCAEVCRRIAASDFAGAVVLEVTTGSARTKPERSALLARSLDFARRHLKRELHPEPLGEFSR
>NZ_CP016594.1|WP_004019965.1|1202754_1203612_+|thioesterase-family-protein
MTSKITEVQELTEVGRGGPDSITLRAHIDATFTIGPKVHGGTLQMVVAKAARTALTALTPDGDRLAESAAAMIPVAISSDYLTAPDAADIDLEISVRKRGRTVTVLTVDAVQLGRTVVSSSVTMARPDSGRPHHSAPTVLDALPVEPSPTGIPLDGSPIAEVNHLGAAIDLVLDSETFPVVRGETGEPLVRGWIRPKGVEPDEYFTVLVGDISPPVVMNLALFGWAPTVQLTTYVRRHPAPGWLRFAATSSEVGPGMFEEDHLVVDSTGTVVAQSRQLALIPSGR
>NZ_CP016594.1|WP_004019964.1|1203618_1204479_+|pyrroline-5-carboxylate-reductase
MSERIAIIGGGKIGEALLAGLIGAGTPTKDLVVAERLESRATEIADEYGVLVTDVRSAAESAQYVFLAIKPDDVDSILRILASAEDNADSERVTVTLVAGLPLSRYESALQAGSPVIRVMPNTPMLVNEAMSAVSAGRYVGDEQLQAVVKILQTVGRVTVVPEKQMDAVTAVSGSGPAYVFLLAEAMIDAGVGLGLTRAQASEMAVQTIRGAGILLSDSGLSAVDLRAAVTSPGGTTAEAIREFEANGLRHAVYQATRACAAASARGGRRVEVEGLAQGHAVTDTP
>NZ_CP016594.1|WP_004019963.1|1204667_1204901_+|helix-turn-helix-domain-containing-protein
MAPADTPGDRTGAVSNAASASQFLTVAEVASLMRVSKMTVYRLVHNGELPAVRVGRSFRVHAKAVHDYLETSYFDAG
>NZ_CP016594.1|WP_003402602.1|1205226_1205328_+|AURKAIP1/COX24-domain-containing-protein
MGSVIKKRRKRMSKKKHRKLLRRTRVQRRKLGK
>NZ_CP016594.1|WP_004019962.1|1205425_1206478_+|NAD-dependent-epimerase/dehydratase-family-protein
MAEPTSAPPRVVLVTGASTFLGGYLVARLAANPDIEKVLAVDSRVPRKDLLRRMGRAEFLRVDIRRPTIAKALAAYDVDTVVHAATSIADTAPHSAAIKEFNLVGAMQVCAACQRTPSVKRLVLRSTAMVYGASSRDPSHFAEETRAPREPKRGYGRDLLDVEGYVRGLGRRRQDIDITIVRPQAMLGPRITTRMSSYLSLPVVPTVIGFQPRLQFLHEEDALAAMEHVTLAGKVGTFNISGEGVVTLTQAIRRVGHVELPVPSSLLAPIAGVFQDLRSAKLRSSQTEFLTYGRVLDTTRMRTELGFVPRYTTLETLDDFIQRSGVTPVIGSDSWRSLEQRVVSAAHQLQ
>NZ_CP016594.1|WP_004019961.1|1206889_1207837_+|acyltransferase-family-protein
MTPISDEITLPDEALGVEHRGPSKSSPLFSLGGLRGAVADTLTSTAGFIRERMAGEYEVDEFGFDPHFTDSVWFPAVRQVYEKWFRVEVTGIENLPREGGALLVANHAGTIPIDAVITSLAVRDNHPEGRFLRVLAADMAFDTPGISEVARRIGATLACNSDADRLLRAGELTAVWPEGYKGIGKLYKDRYKLQRFGRGGFVTTALRNAAPIIPVSIVGSEEIYPMLADLKPLAKILGLPYFPVTPLFPWLGPLGMVPLPSKWHIHFGRPIETGSYDEASADDPMVVFDLTDHVREEIQQTLFRMLSRRGSVYFG
>NZ_CP016594.1|WP_004019960.1|1207876_1209040_+|zinc-binding-dehydrogenase
MRAVVCRNGELTVEEIPTPEPGAGQVLLRVLRAGICGSDLHARVHCDATAEVSAAVGYDAFMRSGQSVVMGHEFAGEVVSYGPGCRKRWAPGTPVVSVPMIRHGSEAHLTGLSESAAGGYAQFVLVSEDMTFEIPEGLPAEHAALTEPMAVAHHAVRRGEVGRRDVAVVIGCGPIGLAVITMLKADGVRTVIASDPSPGRRVLAHRVGADIVVDPATTSPFERCAEAGKYITRAQDLLGAAFDAMRTLRRIPLVPWSSLFRTADRLGATPKGPVVFECVGTPGMIEHVVTEAPFRSRIVVVGVCMEPDTFRPAMALNKEHELRFVFAYDPAEFYDTLHMMASGKVDVSPLITATVGLDGVGAAFDALGGAEHHAKVLIDPMSEVASL
>NZ_CP016594.1|WP_033205387.1|1209377_1211042_+|HNH-endonuclease
MWTDLPGEFVAGVDPDHVGETDMVMLMAGFDATRRGESYLAWHRYQTIAVMADRLVTTTADGFVMDGHADCAARIARQAAVSRRQAENLIDEAIALRDRLSETAETLRDGILSQWQIRLIISRTLLIPADDPITPALDAEIAATLRRRKGVWDRARLRDMVDRLVFRHDPDAVRQRRKDAMDQRGVWTHELSDGTAELTAVMSAENVRISAKAIGILADAVCTRDGRTKGIRRSDAMFALLTRTTFECQCDDEQECTAQIPDPQNLLDAVRAEIVIHVVTDAATLAGAPGVGFLDGHGIICDEHVRDLAARPESTLTPVTPARTAPIYVAETADDAQRWTAQRPAPTQKDCADDGNEPAATHSDEQAGDTTASVAVVYPATHPGNGYRPTTACADFVRVRDGYCTEPGCTRSAFDCDLDHVAEYDHADPARGGATSSENINAKCRPGHLLRTYGDWVDEQYRDEDGRLVTKYTTPEGVILYGDAETLEDTFPNLRRIRFEQAAQAPPSPRVIAPADNPERTHNRLDAKLARRRNERARNRRAREELDRLDPPPF
>NZ_CP016594.1|WP_004019958.1|1211063_1213430_-|pyruvate-dehydrogenase-E1
MTIASPTGDARTTTDALRKVEDRVLWLSTSMIHHANLVRPNATGMKVGGHQASCASMVSIMTSLWFEQLRPGDRVSVKPHAAPVLHGINYLLGLLDESYLTTLREFGGLQSYPSRTKDPDPVDYSTGSVGIGATAPIWGAMARRYIDTRLGADAAGIEAVRADRRSETVLGRQYSLVGDAELDEGAVWEAILDPSVAELGELVWIVDLNRQSLDRVVPNIAAGRLEAMFAAAGWQVIAVKFGRLLETLFAREGGSALRGRILDMPNPEYQRLLRCDADEVRKRLPGKGSDAESVTRVIDDVDDATLLAAIRNLGGHDLDALRTAYDQIDDTRPTVILAYTIKGHGLPTEGHPQNHSSLLTVEQYGELATALGTSVDDPWSGFADGTEAAALCESVARRLRRDPVEPTPPPAVPTDISKTPTGTSTTQAALGRALLALSRAAPEASARVVTVSPDVSSTTNLAGWLNKVGVWSPDERRNWFDDDSETIMHWRERPSGQHMELGIAETNLAGLIGELGATWSRWGQPLFPIGVLYDPFVERTLEPWSYGIYAGGQSILVGTPSGVTLAAEGGAHQSITTPSIGLEQPGCVTYEPAFALDVEWILLSCIGRLGRPDGTSSYLRLSTRPVDQRLADVPTDPAARERRRRHAVAGAYLLRRTSSPQVTLVGMGAVVTETLAAADRLADQGVDADVVCVTSPGLLFEAMQARRGLSDSPSWILDQVFPADRAAPMVTVLDGHPHTLAFLTGVNAVRGAALGVSRFGQVGSLDDVYRLHGIDTESIIRAALDLRR

Crispr_ID: NZ_CP016594_3

• CRISPR_ID: NZ_CP016594_3
• CRISPR_location: 1693068-1693161
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016594_3

Consensus_repeat	Method
CGCTTGCGCTCCTCGCACCTCAG	CRISPRCasFinder

spacers of NZ_CP016594_3

>3.1|1693091|48|NZ_CP016594|CRISPRCasFinder
GGAGCAGGGGTTATGCGGTTCTTTCGGCTTAGGGAGCAGAGCGGTGGC

CRISPR arrays and Neighbor proteins around NZ_CP016594_3

CRISPR arrays

The CRISPR arrays of NZ_CP016594_3

>merge|NZ_CP016594|3|1693068-1693161|CRISPRCasFinder
CGCTTGCGCTCCTCGCACCTCAGGGAGCAGGGGTTATGCGGTTCTTTCGGCTTAGGGAGCAGAGCGGTGGCCGCTTGCGGTCCTCGCACCTCAG

>NZ_CP016594|3|3|1693068-1693161|CRISPRCasFinder
CGCTTGCGCTCCTCGCACCTCAG	GGAGCAGGGGTTATGCGGTTCTTTCGGCTTAGGGAGCAGAGCGGTGGC
CGCTTGCGGTCCTCGCACCTCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016594.1|WP_004020009.1|1691281_1692895_+|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|223587
NZ_CP016594.1|WP_004019993.1|1704511_1705324_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP016594.1|WP_033203669.1|1693259_1694087_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl|CDD|274422
NZ_CP016594.1|WP_004019998.1|1698842_1700444_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004019994.1|1702386_1704510_+|sodium/hydrogen-exchanger	unknown	unknown	gnl|CDD|215608
NZ_CP016594.1|WP_033203671.1|1686971_1687916_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|334634
NZ_CP016594.1|WP_033203823.1|1687975_1689262_+|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl|CDD|225343
NZ_CP016594.1|WP_004020016.1|1685919_1686345_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004019995.1|1700891_1702373_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|238017
NZ_CP016594.1|WP_004020011.1|1689597_1690380_-|AzlC-family-ABC-transporter-permease	unknown	unknown	gnl|CDD|224215
NZ_CP016594.1|WP_004020006.1|1695163_1695646_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004020007.1|1694204_1695167_-|EamA-family-transporter	unknown	unknown	gnl|CDD|273359
NZ_CP016594.1|WP_004020015.1|1686418_1686862_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004019996.1|1700445_1700895_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_033203672.1|1685219_1685636_+|protease-inhibitor-I42-family-protein	unknown	unknown	gnl|CDD|378179
NZ_CP016594.1|WP_004020005.1|1695652_1697254_-|4Fe-4S-binding-protein	unknown	unknown	gnl|CDD|215457
NZ_CP016594.1|WP_004020010.1|1690437_1690998_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_CP016594.1|WP_033203825.1|1684312_1684525_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004020004.1|1697285_1698320_-|diiron-oxygenase	unknown	unknown	gnl|CDD|378680
NZ_CP016594.1|WP_004020012.1|1689277_1689601_-|branched-chain-amino-acid-transporter	unknown	unknown	gnl|CDD|377512

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016594.1|WP_004020007.1|1694204_1695167_-|EamA-family-transporter	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.81208e-17
NZ_CP016594.1|WP_004019993.1|1704511_1705324_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.47715e-37
NZ_CP016594.1|WP_033203669.1|1693259_1694087_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl|CDD|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	5.67713e-06
NZ_CP016594.1|WP_004019994.1|1702386_1704510_+|sodium/hydrogen-exchanger	gnl|CDD|215608	PLN03159, PLN03159, cation/H(+) antiporter 15; Provisional.	8.54014e-69
NZ_CP016594.1|WP_033203671.1|1686971_1687916_+|alpha/beta-fold-hydrolase	gnl|CDD|334634	pfam01674, Lipase_2, Lipase (class 2). This family consists of hypothetical C. elegans proteins and lipases. Lipases or triacylglycerol acylhydrolases hydrolyze ester bonds in triacylglycerol giving diacylglycerol, monoacylglycerol, glycerol and free fatty acids. Lipase EstA is a extracellular lipase from B. subtilis 168.	5.823e-17
NZ_CP016594.1|WP_004020011.1|1689597_1690380_-|AzlC-family-ABC-transporter-permease	gnl|CDD|224215	COG1296, AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism].	1.99853e-33
NZ_CP016594.1|WP_004019995.1|1700891_1702373_+|FHA-domain-containing-protein	gnl|CDD|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	2.25557e-10
NZ_CP016594.1|WP_004020009.1|1691281_1692895_+|DEAD/DEAH-box-helicase	gnl|CDD|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	9.47719e-120
NZ_CP016594.1|WP_033203672.1|1685219_1685636_+|protease-inhibitor-I42-family-protein	gnl|CDD|378179	pfam09394, Inhibitor_I42, Chagasin family peptidase inhibitor I42. Chagasin is a cysteine peptidase inhibitor which forms a beta barrel structure.	0.00420851
NZ_CP016594.1|WP_004020005.1|1695652_1697254_-|4Fe-4S-binding-protein	gnl|CDD|215457	PLN02852, PLN02852, ferredoxin-NADP+ reductase.	1.36296e-118
NZ_CP016594.1|WP_004020010.1|1690437_1690998_+|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.23628e-15
NZ_CP016594.1|WP_033203823.1|1687975_1689262_+|glycoside-hydrolase-family-1-protein	gnl|CDD|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	4.578e-57
NZ_CP016594.1|WP_004020004.1|1697285_1698320_-|diiron-oxygenase	gnl|CDD|378680	pfam11583, AurF, P-aminobenzoate N-oxygenase AurF. This family is a metalloenzyme which is involved in the biosynthesis of antibiotic aureothin by catalyzing the formation of p-nitrobenzoic acid from p-aminobenzoic acid. AurF is a non-heme di-iron monooxygenase which creates nitroarenes via the sequential oxidation of aminoarenes.	1.98694e-116
NZ_CP016594.1|WP_004020012.1|1689277_1689601_-|branched-chain-amino-acid-transporter	gnl|CDD|377512	pfam05437, AzlD, Branched-chain amino acid transport protein (AzlD). This family consists of a number of bacterial and archaeal branched-chain amino acid transport proteins. AzlD is known to be involved in conferring resistance to 4-azaleucine although its exact role is uncertain.	0.00120453

Protein sequences

>NZ_CP016594.1|WP_004020009.1|1691281_1692895_+|DEAD/DEAH-box-helicase
MTAVLENPATTTDAAASTPGVSFESLGVPIELVKVLASQGKTDAFPIQKDTLPDTLDGKDVLGRGKTGSGKTLAFSIPLVAGLAEMQVKRYVGAPTGLILAPTRELATQIAAVVEPLAASVGLTVTTVFGGVKQTRQEQAFRRGVDIVVACPGRLEDLMRQGIVRLDEVEITVIDEADHMADLGFLPVVTKILAATPADGQRMLFSATLDNGVDKLAKRFLDNPVLHSVDSAESPVAAMTHHVFEVSSANKQDLVAELASGTGRRILFMRTKHQAKKLAKKLTEAGIPAVDLHGNLSQAQRDRNLAAFGEGDVRVLVATDVAARGVHVDGIELVVHVDPPAEHKAYLHRSGRTARAGSAGDVVTVVLPEQRREVAQLLRKAKIKVTPVSVDATSAAVDELVGERAPRVFAAARAAAEAARGGGAQNGRSQGGRSQGSRRGGRGRGQGGNSSARGENRSAGTGGGRNSAGGDSRGTRGEGRGRPARSDSRSGGSRSAEGRTGGQGRGAGHSRAGDQQRAGSRGQGRRVSRPAGSPTGR
>NZ_CP016594.1|WP_004020010.1|1690437_1690998_+|helix-turn-helix-domain-containing-protein
MNETRVNPKELVAASLKRERTRAGLSLTELARRAGIGKSTLSQLESGEGNPSVETLWALSTALGVQFSALLDSPTPTVEVIRFGEGPVIPAADADYSATLLSTAAPGSRRDMYVIRAEPGKPRISAPHARGIIEHVVISCGRARLGPTDATEVLLAGDYISYPGDVEHVFDALEPGTVAVMLSEAF
>NZ_CP016594.1|WP_004020011.1|1689597_1690380_-|AzlC-family-ABC-transporter-permease
MRSAWRTLDTATLRAVVVMSLSVLVIGTSYGVAAHGAGLALWQIVLIATVVLAGSSEFVFVGILAAGGAPILAALAGLLVNTRNFGYGLAVGKHLRGTPELVVGAHLINDETAALATAESDPRRARAAFLLCGLGVLVSWPVGAALGATLGGVVADPASLGLDAAFPALLAALAIPALRDGATWAAVTVGAAVAVASTPFLPAGLPIMGALVGFAAVESLRRLRRTPPSAPALPGTRTDTVNETASSREALQHNGVPGCR
>NZ_CP016594.1|WP_004020012.1|1689277_1689601_-|branched-chain-amino-acid-transporter
MSTGISLAIGITVLAVGTYAMRAAGPVLRNRISVSDGVERLMDRATVVLLVAVALTGAFFIDHDFAGWARPIGVTVGVIAALLRAPLAVVVILAAATAAGLRALGLA
>NZ_CP016594.1|WP_033203823.1|1687975_1689262_+|glycoside-hydrolase-family-1-protein
MSCAAMLLAICGLGGVGTASASVPPLGPAFEFGVAQSGFQSEGYNRDSNWVRYGNQGRVAHRVGNAVDFYHRYAEDIARAKSLGVGIYRTSVEWSRVQPSRGRDDPAGWAFYDRVIRAVVDAGMRPMITLNHWVHPGWAVDLGGWNRPQMSADLVRFAERVVDRYSWADPLWITFNEPTEYVRRELMYGGVAPQNVGLMADGIVAAHRSIHRYIHRVQPGAQVSSNMAYYPIAGLQTWLESVFPQRMRDTLDFVGIDHYYSFSVTDASVANGATGEFWKSSQAPESIYYVLRHVAHQFPGKQIRVIENGLATDPQGRRPDGYRRADHLRDTVYWLQRARQDGIDVASYNYWSLTDNYEWGDFDSRFGLYTVDAERDPTLTRHPTDAVAAYREITRDNGVRPGYRPTRMPVTCSLVAVPDSCANPAVVR
>NZ_CP016594.1|WP_033203671.1|1686971_1687916_+|alpha/beta-fold-hydrolase
MRSPKIVWGLVVAVIGVLVVTVAPARADPLPVTYNFLAGIPNELAKPGGSLPGSNDWTCKPSARHPNPVILVHGTGGSQQTNWGTYVPLLKNEGYCVFAPTYGAVKGTPWPISAIGGMGEMSASAAQFGAFVDKVRRTTGASKVDIVGHSQGTVVPAYYAKYLGGRDAIGNYVSLAPAWRGSGVGGNDVIMPIARSLGLQPEQVPFCQACAQLDPGAAVLRKIAAGGYYLPSIRYTNIATRYDELVVPYTLGLPPGGSNVRNIVVQDGCSVDYTEHAGIAGSRRAAFFVLNALDPANPRPVPCDRAAPITGSPF
>NZ_CP016594.1|WP_004020015.1|1686418_1686862_+|hypothetical-protein
MTAAMLTFAGTLLVAMIGAVIARLDANDRHQKLSQKVDILAKLPHDSAAHARMSGIVLDAIDELAEYEHRRRSAVFQRRALTMALLAWLVVVGLRIAAEQFDVGHYEQIMHYVAVTLLVLGFVLVFASVVATIRDIRHRHDEEPASN
>NZ_CP016594.1|WP_004020016.1|1685919_1686345_+|hypothetical-protein
MKPLLGPPRVRFGLDPAAAINGAWYPYTLRLAEELPGMLAAARPQIGEVTGIDVNWSSFRRLPGLDSPDSPEMPPLMTLTCGGKTVMLLVIPPRTASSLAAILLRQASDTAAPGGQCHSLEYRRAERILVRAGGHGARAAR
>NZ_CP016594.1|WP_033203672.1|1685219_1685636_+|protease-inhibitor-I42-family-protein
MIAGALVGCAGTTTGSGTPVGSSTRGLSVPSTVGEVHLDVGDTLAVEFGTVNYSVGDQWRVADDPDPEVLTPLLADGSGGEQEPAPPGSAIELTMRFVAVAPGSTSIAFEYSYRGGAGTPPDSGPRRRTVTVTVAGQS
>NZ_CP016594.1|WP_033203825.1|1684312_1684525_-|hypothetical-protein
MRAWSANPAHMSASVTYSNSYRWAHWRYRSELSWALGFTTLGNTGASDGEINFARIDRFGAHSQATYVLG
>NZ_CP016594.1|WP_033203669.1|1693259_1694087_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MWGEEPRATGMFSRFDYIDAALTTGDRFTDLVLGVDDPDTRLPDVPGWTLTDCLGHVASAPSRFLGLARGEGEWCCSAVDVPDFNAKQIANLPTRDVRLLCRRLADDLRELVDEVSHFHAQVPKMHFDGDRLIRADAALGLLIGEFVVHAHDIARAVGARWWVEPEVVSMIIRARQHILPSWVDPVNAAGHSGTYDIRLRGCGERHVYEFTDGELVIDPPEPRRPDVHISVDPATALLAGYGRVSPGWIGLTVKAIAWGARPWLAPRLAQRFLPA
>NZ_CP016594.1|WP_004020007.1|1694204_1695167_-|EamA-family-transporter
MSSADRTPALPRPALGITLALISSACFGISGVLARAMIEAGWSAGATVTVRIALGGLVLAVPGLLAFRDRRRPVPDRPGRRSWPVLVSYGLLAVAGCQLAYFYAVTYLQVGVALLIEYTAPVAVLVWMWLRHGQRPGRVTVLGAALAIAGLALVLDLTGDVPISAVGVLWALAAMVGAAAYFVISADDRTGWPPLSLAAGGLLIGALALVGAGLTGLLPMTMTTVPVRVGALEVAWWVPLVLLGVVSAAMAYGFGIAGGRLLGARVMSFVALSEVLFAVVFAWLVLDELPAPIQLAGGLLIVLGVVCVRLGEAAPAASHD
>NZ_CP016594.1|WP_004020006.1|1695163_1695646_-|hypothetical-protein
MGPAYQRTTVRADLSDLPADVAATLRDHAESKQLTVTDDLPAWITRSINPPSTTFLGKVFGRRSNPVDPDSEHQTLIVLHPTHLIVVVSGAKRGVAALSCPLGVASMSSTPYVPESDGFSVTGFAGDEGRPGSFYLGTGEPAGPECREAVRTAIVAAKNP
>NZ_CP016594.1|WP_004020005.1|1695652_1697254_-|4Fe-4S-binding-protein
MPHVVTQACCGDASCVYACPVNCIHPTPEEPDFGIAEMLYIDPATCVDCGACVSACPVGAIVPGHRLPAGQERFVEVNATQYHDPADGAARFPVDPARRLPLAPIDRPRQLAVERSISIGIVGSGPSAMYAADELLRQPQVSVTMYERLDRPFGLARFGVAPDHLHTRKVMELFDDIARNPRLEILLNTEVGRDLTLADLRARHQGVIWAGGAPTDRRLALPGFDLPGVSSATSFVGWYNGHPDFTDLDVDLDTERVVVVGNGNVALDVARILVADPDTLAATDISRSALATLRASSVREVVVMGRRGPAHAAFTLPELIGLVDSGVPVTVDAADLDALPAPADLDATVRGKLEILAECAARPEPTGRRIRLAFFSSPSEVTAGPHGRASALVVGRNRPVVDDAGSAVGIEPTGDTTTLETGLVLTSVGYRGVPVPGLPFDDAAGVIPHLDGRVLDGTEPVSGMYVTGWIKRGPSGFIGTNKTDSAQTVASLLDDLEAKAPEVSVPRRRRLLGRRLGVAQSVAGLDGGATALD
>NZ_CP016594.1|WP_004020004.1|1697285_1698320_-|diiron-oxygenase
MTKALTPTDREHEAPARYVPQHDKSGGDHDYSQVLDDLSAASVHRNFDPYVDIDWDAPHMAITENDPRWILSYEVDPIGRHPWYQQLPQEKQIEIGMWRQANVAKVGLQFESILIRGLMQYSFKLPNGAREFRYTTHESKEECNHTLMFQEFINRTGVDVPGAKIGYRLISPFVPLVSTVFPTLFFFGVLGGEEPIDHIQKDFLRTRASLHPTMAAVMQLHVAEEARHISFAHHLIREQVPQRGRFQRFILSLMLPLTMRILCGAIVVPPRGFAKRFDVPDEVMKDIFWRSAESKRFLRNVFGDVRMLGEQSGLMNPVSRLLWRALGISGRPSRFRSEPTYTAA
>NZ_CP016594.1|WP_004019998.1|1698842_1700444_+|hypothetical-protein
MPRQAPRSPNRGAPGPGGALGDLTPQLIDTDIWTDAMVEGAGIPVVDVPFVTVGSGIGSFVTVDYLRISGVPLDRIAVLGPQDVPWHSYEYLTRVSQIPRGERLRSDSASTPDNIWGFPSYAVREAWADKKFKPLWNVLVEPVFANFYTPKAGQAFASMEKECERIGYLKCLHRGQVRMIRRRAGGGYFTILTPPQGSSPTKRVAFRSQWVHVAIGYPGIKLLPDLQAFRETYRDASKVVNAYESHEHIYQSLQRKPGTVVIRGAGIVASRVLQRLIDDRDAYGLQTQIVHLFRTYYDKPHGPHIFMRRKGKDGWAYQGFNYPKSVWGGQLKARMRKLEGHERAEAYKQMGGTNTPVRDDWQEQLARGRREGWYRVAVGKAESLVPAAGGQGVVTTVRVDPHAPIRQDHRPDGTFEIYADYVIDCTGLEADVREHRLLRDLLDHTGAGINPVGRMDVERDFELKGTRSGNGKLYASGSATLGGYFPGVDTFLGLQIAALEIVDDLARQGFCKRLTPWRSTAQWWRWMNNKGVD
>NZ_CP016594.1|WP_004019996.1|1700445_1700895_+|hypothetical-protein
MLPTLWGRIQTRVLVLGILGGLWTIVLVPFLWLISSGDPTILDVYRVAFTVLVTVIVLGVFWEFLYHFLQQFRWEKDWPTLFGLLTAINEGILVWVVIDNTGLIPESLRPSPFVFSVQFVTTWLLVWVAVNGPLRAVFPHWRFQGGRFL
>NZ_CP016594.1|WP_004019995.1|1700891_1702373_+|FHA-domain-containing-protein
MTSPGDIPSVTPTVTLIRGEGVVIRTPAFLCLVNDAVPASFLTDLLDIESAVSVPDSAPRRGRHLVRALAQLVATAADPVDIAFAAPDSAGIAIFLSGRVYGETDGKRVEAAAGDTYDRAVPWPYEGLGLYLAGTEPAEVGEERFDLVEGTVPAAGALLHTPLGLRGTEFHAVSDRAAQPRPDGAAQPRPDRVVEPSRPDPDAGPPTEALGGLDEPDHPEMPRTPAPEAEPEPDPMGTTERMAPGAGSPGSPAPDPLPFTSTPLGGPFEAEPLSPNAPLPSEPAPRDVMPPGGRAPVEPGAASNPFAEPLEPRAPLPKAEHQKPATEVVKIEASRAMVHGIRCSRGHLNHPQSWLCGVCGIRMDQLTTFLVEGERPPLGWLLLDNGFTFLLDEDLVIGREPGSAGGGPAASPKPIRVQDETGQLSRRHVEIRLVEWTVQLVDLGSANGTFVADPSNGNRETRLLPHRAHVLVPGSHVRIGGRHFIFESHHARI
>NZ_CP016594.1|WP_004019994.1|1702386_1704510_+|sodium/hydrogen-exchanger
MEKHTIAFLLLDVAVVIAAARVGGMIARACRQPAVVGEIAAGIALGPSLLGLLPGNPDQWLFPDDVRPLLGALAQIGLVLFMFIVGLELDMRLTKGRERAAASISAFSIALPFALGAGLGVLLYPSHNMVGGMEIERLGMVLFMGVAMSITAFPVLARILTDRGMMRTVPGVFSLAAAAIDDILAWTLLAFIIAIIQGGSPLEVAKIVGLTLVYAAVMFGVVRPLLAKLIAWRDTAGRLTPDILAVILIGLFLSAAATDVIGIHQIFGAFVFGAVMPKVGAEQLHREILERLEQASVLLLLPMFFVVTGLNVDLTEIGFAGMGQLLLVLLVAIAGKFVGAYAGARVSAIPTRQSAAIAVLMNTRGLTELVILAAGRELGVLSDELFAMLVVMALVTTILTEPLLRVVYPDRVVANDIAAAERRALATATAPRVLVLIRDPVGTVADLRARHRRMLDCATGFDVVLAGLLTAPDRSARPLEVGIPVVPDFAAIASAVEKLSELGSSLTGAGSVSVLCRFSADPAADLDAMSENAHADIIVVDSVDRSLGESLRSAPVAVIDEAADAAVAPGRSTVTCFAADSRSGRTAALVAAGLALFGSRSLTVVASGSRRRWLADLNAVAEQGVSVSVQDPRRHRDDAVSFAVAAPDEGGPGAPVPVTVVDNTGTSEESLGDRVAALYPPPVAQPTPSRAAPDTSSPDIGSSSERH
>NZ_CP016594.1|WP_004019993.1|1704511_1705324_+|protein-kinase
MATVEIPQQLADFTVLEKLGMGGNGTFYLAVPPARLGLRTDRVVVKVFGGVCSDDAYRRGVRELRAFAAVVSPYLAGLYDAVLQGQFMYAMEYFPLGSLGSPAREFSRDEKLAAIADAARGVDALHEAGIAHANITPSSIMVTDTGGKISDLGLARVLAADEPITSFAQPGAVQYMDPALLAGDVPSRATDIWSLGACLHRALTGDGVYGEVPDAQPLLAIRAALSTPPALSENLDRDERTLIANCLALAGSRPSTASEVAGRIDALRGR

Crispr_ID: NZ_CP016594_4

• CRISPR_ID: NZ_CP016594_4
• CRISPR_location: 2614481-2614583
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016594_4

Consensus_repeat	Method
CTGAGGTGTGAGGGGCGCAAGCGAC	CRISPRCasFinder

spacers of NZ_CP016594_4

>4.1|2614506|53|NZ_CP016594|CRISPRCasFinder
CCTCCTTCTGCTCCCTGAGGTGTGAGGAGCGCAAGCGATCCTCCCTCTGCTCC

CRISPR arrays and Neighbor proteins around NZ_CP016594_4

CRISPR arrays

The CRISPR arrays of NZ_CP016594_4

>merge|NZ_CP016594|4|2614481-2614583|CRISPRCasFinder
CTGAGGTGTGAGGGGCGCAAGCGACCCTCCTTCTGCTCCCTGAGGTGTGAGGAGCGCAAGCGATCCTCCCTCTGCTCCCTGAGGTGTGAGGAGCGCAAGCGAC

>NZ_CP016594|4|4|2614481-2614583|CRISPRCasFinder
CTGAGGTGTGAGGGGCGCAAGCGAC	CCTCCTTCTGCTCCCTGAGGTGTGAGGAGCGCAAGCGATCCTCCCTCTGCTCC
CTGAGGTGTGAGGAGCGCAAGCGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016594.1|WP_004018785.1|2609515_2611237_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|173866
NZ_CP016594.1|WP_004018786.1|2608308_2609505_+|protein-translocase-subunit-SecF	unknown	unknown	gnl|CDD|237275
NZ_CP016594.1|WP_033203427.1|2606596_2608312_+|protein-translocase-subunit-SecD	unknown	unknown	gnl|CDD|235615
NZ_CP016594.1|WP_004018778.1|2617845_2618517_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP016594.1|WP_004018794.1|2602792_2603548_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|234640
NZ_CP016594.1|WP_004018789.1|2604812_2605901_+|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl|CDD|234619
NZ_CP016594.1|WP_004018792.1|2604218_2604812_+|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl|CDD|234645
NZ_CP016594.1|WP_004018776.1|2619304_2620120_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|181136
NZ_CP016594.1|WP_004018779.1|2616564_2617830_+|histidine--tRNA-ligase	unknown	unknown	gnl|CDD|234586
NZ_CP016594.1|WP_004018777.1|2618630_2619308_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004018773.1|2622818_2624639_+|aspartate--tRNA-ligase	unknown	unknown	gnl|CDD|234775
NZ_CP016594.1|WP_004018784.1|2611253_2611829_+|adenine-phosphoribosyltransferase	unknown	unknown	gnl|CDD|235028
NZ_CP016594.1|WP_004018796.1|2602016_2602637_+|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	unknown	unknown	gnl|CDD|237411
NZ_CP016594.1|WP_004018775.1|2620136_2621810_-|DUF885-domain-containing-protein	unknown	unknown	gnl|CDD|377577
NZ_CP016594.1|WP_033203425.1|2614696_2615617_-|peptidylprolyl-isomerase	unknown	unknown	gnl|CDD|223725
NZ_CP016594.1|WP_004018788.1|2606050_2606434_+|preprotein-translocase-subunit-YajC	unknown	unknown	gnl|CDD|376903
NZ_CP016594.1|WP_004018774.1|2621820_2622678_-|peptidase	unknown	unknown	gnl|CDD|225203
NZ_CP016594.1|WP_033203429.1|2603652_2604222_+|crossover-junction-endodeoxyribonuclease-RuvC	unknown	unknown	gnl|CDD|234587
NZ_CP016594.1|WP_033203546.1|2624737_2628223_+|transglutaminase-family-protein	unknown	unknown	gnl|CDD|378297
NZ_CP016594.1|WP_004018780.1|2615827_2616568_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293792

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016594.1|WP_004018785.1|2609515_2611237_+|ABC-transporter-substrate-binding-protein	gnl|CDD|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.26161e-63
NZ_CP016594.1|WP_004018786.1|2608308_2609505_+|protein-translocase-subunit-SecF	gnl|CDD|237275	PRK13022, secF, protein translocase subunit SecF.	4.00967e-105
NZ_CP016594.1|WP_033203427.1|2606596_2608312_+|protein-translocase-subunit-SecD	gnl|CDD|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	8.04888e-112
NZ_CP016594.1|WP_004018778.1|2617845_2618517_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	0.000502872
NZ_CP016594.1|WP_004018794.1|2602792_2603548_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl|CDD|234640	PRK00110, PRK00110, YebC/PmpR family DNA-binding transcriptional regulator.	1.258e-148
NZ_CP016594.1|WP_004018789.1|2604812_2605901_+|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl|CDD|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NZ_CP016594.1|WP_004018792.1|2604218_2604812_+|Holliday-junction-branch-migration-protein-RuvA	gnl|CDD|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	6.2006e-76
NZ_CP016594.1|WP_004018776.1|2619304_2620120_+|SDR-family-oxidoreductase	gnl|CDD|181136	PRK07825, PRK07825, short chain dehydrogenase; Provisional.	1.598e-101
NZ_CP016594.1|WP_004018779.1|2616564_2617830_+|histidine--tRNA-ligase	gnl|CDD|234586	PRK00037, hisS, histidyl-tRNA synthetase; Reviewed.	0
NZ_CP016594.1|WP_004018773.1|2622818_2624639_+|aspartate--tRNA-ligase	gnl|CDD|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NZ_CP016594.1|WP_004018784.1|2611253_2611829_+|adenine-phosphoribosyltransferase	gnl|CDD|235028	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional.	8.35438e-67
NZ_CP016594.1|WP_004018796.1|2602016_2602637_+|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	gnl|CDD|237411	PRK13525, PRK13525, pyridoxal 5'-phosphate synthase glutaminase subunit PdxT.	2.33482e-115
NZ_CP016594.1|WP_004018775.1|2620136_2621810_-|DUF885-domain-containing-protein	gnl|CDD|377577	pfam05960, DUF885, Bacterial protein of unknown function (DUF885). This family consists of several hypothetical bacterial proteins several of which are putative membrane proteins.	2.47446e-156
NZ_CP016594.1|WP_033203425.1|2614696_2615617_-|peptidylprolyl-isomerase	gnl|CDD|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	8.76115e-28
NZ_CP016594.1|WP_004018788.1|2606050_2606434_+|preprotein-translocase-subunit-YajC	gnl|CDD|376903	pfam02699, YajC, Preprotein translocase subunit. See.	1.005e-22
NZ_CP016594.1|WP_004018774.1|2621820_2622678_-|peptidase	gnl|CDD|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	2.37745e-82
NZ_CP016594.1|WP_033203429.1|2603652_2604222_+|crossover-junction-endodeoxyribonuclease-RuvC	gnl|CDD|234587	PRK00039, ruvC, Holliday junction resolvase; Reviewed.	2.60529e-75
NZ_CP016594.1|WP_033203546.1|2624737_2628223_+|transglutaminase-family-protein	gnl|CDD|378297	pfam09899, DUF2126, Putative amidoligase enzyme (DUF2126). Members of this family of bacterial domains are predominantly found in transglutaminase and transglutaminase-like proteins. Their exact function is, as yet, unknown, but they are likely to act as amidoligase enzymes Protein in this family are found in conserved gene neighborhoods encoding a glutamine amidotransferase-like thiol peptidase (in proteobacteria) or an Aig2 family cyclotransferase protein (in firmicutes).	0
NZ_CP016594.1|WP_004018780.1|2615827_2616568_+|MBL-fold-metallo-hydrolase	gnl|CDD|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	1.07147e-64

Protein sequences

>NZ_CP016594.1|WP_004018784.1|2611253_2611829_+|adenine-phosphoribosyltransferase
MGGVVPERTAEAVSRARAAIAEHARLVDDFPAPGIAFKDLTPVLADPEGLSTIVTALTHGCSSIDLVAGIDARGFLLGGAVARELEVGVLAVRKGGKLPPPVIAVDYSLEYGQATLEIPANGLNLTGRRVLLVDDVLATGGTAVAAAELLHRAGAQVVGVAVIMELAGLGGRDTIARGLGPDVPVHAVASD
>NZ_CP016594.1|WP_004018785.1|2609515_2611237_+|ABC-transporter-substrate-binding-protein
MIVRRREFVRVLSLLVGVVSVAGLLTACGDDGPPTIDYVVDARISTYNANTVGGNADGVLMATTRLLPGFSLLGPAGQVIPDRDIGTVTQVPGRSPTLRYEFRPEATFSDGVALDCDDLLLAWAAMSGRMPGFTPATTAGYRDIESVDCAAGDKSATVTFAPGREYRNWLSLFGAGTLMPAHVVARVAGLSDVIDPIRAMDRAAVGRIADAWNTDFDLGFGPVDHAHYPASGPYRIDRYSRSGGLVLVPNDKWWGDKPETSRIVVWGRGTDATRRLPDGRFDVVDVTAGLVDGDVAGSAGPAGPASPARALGVEELVLAGRGVFGDVRMRRAFASCVPRADLARDFGGGAQVWNLRVLSPADNLAGQMNTEFGQAYQRPDIERARGLVRAATGQGEDSATGDTTTSAVATRTVRIGYVAPTPRWQQMTAAIAASCRGAGLAVEDVSSPDIGPDALGRDADVLIVAGGASFAAAGAADPSRDAYALRGGDPLNLSGIREPMVSRGVDQLATTVSAPDRLRLARSIENATWSTMPSVPLFAAPRVRQWKDRVGNVVAGMGRDGTGWNMDRWTIRG
>NZ_CP016594.1|WP_004018786.1|2608308_2609505_+|protein-translocase-subunit-SecF
MTGPDNKAAGDSAVLDADKAQPGADADFVADRNRSFLSRLYTGTGAFQIVGRRRMWYGVTAAILLICLASIGIRGFTLGIDFEGGTQMSVPVASSEITAESVEKVVADTLGEAPESVQTAGAGGSQTVQVRTETLDLAQAESVTRALADEFGPELAPAEVSISDVSSTWGSEITERMLIALVVFLVIVFVYIAVRFDREMSIAAMGSLFFDLIVTAGIYSLVGWEVTPATVIGLLTILGFSIYDTVVVFDKVSENTRSVLQTTRRTYAEQANLGVNQTLMRSINTTVISVLPIIALMVIAVWLLGVGTLKDLGLIQLVGVLVGTFSSVFLAAPLLATLKERRPEIARHTDKVLKRRAAVEAGAPVGDARPVRTQRRGETVETDEADRAVPTGKRRRNR
>NZ_CP016594.1|WP_033203427.1|2606596_2608312_+|protein-translocase-subunit-SecD
MTTPSRTSGKGRTAGKRSRPAREIPPWRPLVAFIGLLAVVYGLIFFTGPQTIEPKLGIDLQGGTRVTLTARTEDGQAATREQLDQAKQIIEQRVNGLGVSGSEVVVSGDNLIITVPGQDGAQAKSLGQTARLYVRPVVGQPAMATPQPPKPESADDQADALPTEAAAAAIDEQRRLRQAPANATPQQLEALQQQMAKMDCSPTANDPLLGNDRPDQYLVACSTDGSEVYLLGPEIIDGRDIKNANAGTDPQTGEWVVTLEFEGEAANFWPRYTAEQAPNRTQTAFTLDSRVVSAPAINEPIPGGQTRISGGSASPFTESSSNELANVLKYGSLPLSFTASDAETISATLGLASLQAGLIAGLVGLIAVFIYALAYYRMLGILTVLSLVLAGAMVYGIIVLLGRWIGFTLDLAGIAGLIIGIGMTADSFVVYFERIKDEMREGRSFRSAVPRGWASARRTIWSGNAVSFIAAAVIYVLAIGEVRGFAFTLGLTTILDVMVVFLVTHPLVVYASRSTFLSKPSVNGLGAISEVARQRRVAAHRQASATPDGTPAGTADADDTTDATREKGTVR
>NZ_CP016594.1|WP_004018788.1|2606050_2606434_+|preprotein-translocase-subunit-YajC
MDALLFPLLLALLAGFMFLSMRKQKKRVAEMQEMQNSVSTGTRVQLTSGLFGTVIDASSPDVVDVEIATGVVTRWNRLAVMRVVPTDEAAATYAGHVAPEIPSDDYDDVDSVSLDKPAADDARDTDK
>NZ_CP016594.1|WP_004018789.1|2604812_2605901_+|Holliday-junction-branch-migration-DNA-helicase-RuvB
MFDDTDDVDDRDVSATPVRSDGDLDAGLRPKSLADFIGQPRVCEQLELVLHGAKGRGGTPDHILLSGPPGLGKTSLAMIIASEMGAAIRVTSGPALERAGDLAAMLSNLVEGDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLDVAPFTLVGATTRSGSLTGPLRDRFGFTAHMEFYEPDELVRVLHRSAGILGMELRGDASGEIARRSRGTPRIANRLLRRVRDYAEVRGDGSITVDVARAALAVYDVDELGFDRLDRAVLDALIRAFGGGPVGVSTLAVAVGEEPATVEEVCEPFLVRAGMIARTPRGRVATAAAWHHLGLTPPAGAMNATFGVRPRDVGAETLFDDL
>NZ_CP016594.1|WP_004018792.1|2604218_2604812_+|Holliday-junction-branch-migration-protein-RuvA
MIASVRGPVLEIALDHAVIDCGGVGYRVLATPATLSRLRRGDEATLLTSMIVREDSMTLYGFTEPDARALFALLQTVTGVGPRLAMATLAVLEPDALRRALAESDTKALTSVPGIGKRVAERLCVELRDKVDRPTGEPASGVTVVGGIREQVAEALVGLGFTAGPAEKAVTAVLAEHPDADASTALRHSLSLLGKAS
>NZ_CP016594.1|WP_033203429.1|2603652_2604222_+|crossover-junction-endodeoxyribonuclease-RuvC
MRVMGVDPGLTRCGIALVESARGRSVTALDVDVVRTPSDMDLAERLLAIYTSACHWLDVHQPDVVAIERVFAQNQVSTAMGTAQAGGVIALAASQRDVPVRFHTPSEVKAAVTGSGRADKAQVTAMVTRILGMQTKPRPADAADALALAICHCWRGPMMERMAAAQKQADAAAARHRARVAQAREGSRA
>NZ_CP016594.1|WP_004018794.1|2602792_2603548_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MSGHSKWATTKHKKAAIDAKRGKMFAKLIKNIEVAARTGGGDPAGNPTLFDAIQKAKKSSVPNDNIERARKRGGGEEAGGADWQTIMYEGYGPNGVAVLIECLTDNRNRAAGEVRTAMTRNGGNMADPGSVSYLFTRKGVVTLEKNGQSEDDVLMAVLDAGAEEVTDLGESFEIVSEPSDLIAVRSALQEAGIDYDSAEASFRASVEVAVDADGARKVFKLIDALEDSDDVQNVYSNVDISDDVLAELEND
>NZ_CP016594.1|WP_004018796.1|2602016_2602637_+|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT
MTATNRPRIGVLALQGDVREHVHALEASGADAIAVRRPAELDEIDGIVIPGGESTTMSKLLGIFDLFDPLAEKLSDGLPAYGSCAGMIMLASTILDTRPDARHLDALDVTVRRNAFGRQVESFETDLDFAGITDAEGAAPMRAVFIRAPWVETIAPEVKVLARVPDGPAAGRIVAVRQGNVLATSFHPEVTGDRRVHEYFVEMVRR
>NZ_CP016594.1|WP_033203425.1|2614696_2615617_-|peptidylprolyl-isomerase
MSTNEERREAAKRKLEERLETERRARRKRKIVIASVSTAVVVAVVAGVTAVVVKKIMDDREAARWTTCAYEDSPSRFDQLPDQVPDTVPAEQRPQYQAELDELKAAAKNERTSPKPDERVLKSGTEQATFVTTQGTLPITLERDGAPCNTAAVTSLIENKFYDDSTCHRMTTSETLKILQCGDPTGTGMSGPGWTSPDEPPTDLQPAGQPDPQTGSAPVTYPRGTIAIANSSQGGQNPNTGSSQLFIVINDSQLGPDYSIVGKVDEPGLAVLDKVYAGGINPGPVGSQPGDGEPKLPVTIETATIN
>NZ_CP016594.1|WP_004018780.1|2615827_2616568_+|MBL-fold-metallo-hydrolase
MLITGFPAGMFQTNCYIVAAEAGSDAVIIDPGQDAAPRVRELLAEHDLTPVAVLLTHGHLDHTWNATELCDEYSIPAYIHPADRPMLADPGLGIGRALGAMIGDEVFTEPAKVIDFADGEPVELAGISFSVDLAPGHTQGSVLLGVEVDVPDEAREQGGPDTPAVVGVCFAGDVLFAGSIGRTDLPGGNHQQLLDSIAAKLLPLPAETLVLPGHGPQTTIGQEGASNPFLAGLDSQSARPKGRHGL
>NZ_CP016594.1|WP_004018779.1|2616564_2617830_+|histidine--tRNA-ligase
MSGAFQAPRGIPDYFPPNSADFRRVRDTLTDAARRAGYGHIELPVFEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIQHGLDRGQLPVKVCYAGPFFRYEKPQTGRYRQLQQVGVEAIGVDDPALDAEVIAIADEGYRRLGLTGFRLEITSLGDDESRPRYREALQEFLFGLDLDEATRMRAEINPLRVLDDKRPEIKAATAGAPLLIDYLSEDAKAHFDLVLAHLDRLGVVYEINPRLVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRQLGAKQDLSGIGFGIGVDRTMLALEAEGVAGTEAARCQVFGVPLGTAAKAELVGVAGALRAAGISIDLAYGDRGLKGAMKAADRSGARLALVLGENELAERQLEIKDLSNGEQHRVALDEVVAEVGRLLG
>NZ_CP016594.1|WP_004018778.1|2617845_2618517_-|TetR/AcrR-family-transcriptional-regulator
MSSTSTDRSYGGESAAGRTARRRAALVDAASTVMSDGRWRAATVAGLCTDAQLNKRYFYESFPDLDALADAVIDDISGEVVQAAVGAYLGLLDRPLADQARGAVDAVVGVLGTDRRKARILLGGAAGTPAADERRTEAMTGLTAVLIEHARTIHDVELEADSLARTAPAFVIGGSAQAILAWAEGTLPVSRADLVDDISALWLALGTAASELARARLESGRVE
>NZ_CP016594.1|WP_004018777.1|2618630_2619308_+|hypothetical-protein
MSAELNTARDVDEASPTELQMLAELRSLADHSPLRARCEAWDFLRQLGDRDDREALSTLFGAGSDPQGLDGRLEGLIVGKLFGIPEAALANPLMKIDPTWRGKSFDQRSGTGLNRLSPIAALVMPIITAGYLGLRPVEGEMEGFHFEHEPSLGLIEPKVRVRALDYGVPKYKNPGVRTFPIRKTRDEIVELVPGVYLGRALLFRSSGEIRLIAYFALRHPIGSPL
>NZ_CP016594.1|WP_004018776.1|2619304_2620120_+|SDR-family-oxidoreductase
MIALQGARVCVTGGARGIGAATAAALVERGATVWIGDRDLDAATATAERLGRRAHAVRVDVTDVDSFAAFVDAAKSTGPIDMLVNNAGIQHMGRLVDQDLAGLHRELAINLGAVVTGTHLVLPGMIERGRGHIVNVSSMAGKVTTPGIATYCASKFGVVAFSKAIRAELTGTGVTMTTVLPAATHTDLTAGVRLRLQPTLEPADVAAAIVASVEHGRGEVTVPRYLAPIGILEDLIPSPIMWRLKRFVGGADYGAFDEGQRQAYLDRSRAS
>NZ_CP016594.1|WP_004018775.1|2620136_2621810_-|DUF885-domain-containing-protein
MNPTDTVGARRPTTVDAIAEAHLDRLCTLNPLFATEIGHGEHDDRMTDFSAQGCAERAEVAAGTLSALADADITDPIDRVTVATMSASLRRELALADAGEHIGECNVIASPLQALRDVFDLMPTDTREQREIFLSRLTAIPASLTGVVDGLAHRLRHGPPPARRQVEAVARQADSAADAIGGATGPIAADTALAGTLATALDAARTSFGTFAHYLRTEVLDHALDDDAVGRDRYLLHLPAYLGADADPDDAYAWAMTRLQQIIAEQQEIAEGLLPGQGIGATLAWLDRQPQYQIHDRAQFVDWMQATSDAAVTGLSGIHFDLPARLSRLECRLAPSSTGIIYYTQPSADLSRPGRMWWAVPDDQTVFHTWQEKTTVYHEGVPGHHLQLGSAIVDPDLNSWRKLASFTSGHGEGWALYAERLMDELGWLEDPGDRMGMLDSQRLRAARIVVDIGVHCRLPAPESLGGGIWDADKAWAFLTSSVAMDHSVLRFELDRYLGWPGQAPSYALGQRVWEQTRTAALRLHPEWTLKDFHSRALALGGVSLDVLAAEVAGRPAS
>NZ_CP016594.1|WP_004018774.1|2621820_2622678_-|peptidase
MTFQGSGSIDTGNVSGGGGGGGGRIALGGGAGLLITIVALFFGVNPGDLLGSGGPAPGTSSDAAQIQQQLDSCTYEMANENTICRIKATTVSVDSVWSDLWPEYEAPQTVIFADAVNTGCGSASSATGPFYCPADSTAYFDPTFFAQLRRMGGSDGPLAQEYVVAHEYGHHVQNLTGALAKGQRMGSQGPRSGSVRVELQADCLAGVWAHHADDGPDALLAPITEEQIAGVIQTAKAIGDDTIQGPGSNPEGWTHGSAAQRTRWFSVGYQGGDPDRCDTFATDDL
>NZ_CP016594.1|WP_004018773.1|2622818_2624639_+|aspartate--tRNA-ligase
MLRTHSAGSLRRADASQTVTVAGWVARRRDHGGVVFIDLRDATGLVQVVFRDESVASAAHRLRAEYCVAVTGVVEVRPEGSENPNLSSGEIEINAVGLEVLNESAPLPFQLDESPGEEARLRHRYLDLRREGPSAALRLRSKANAAARGVLAAHDFTEIETPTLTRSTPEGARDFLVPARLQPGTFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDIEMSFVDQDDVIAVAEEVLTALWKLIGVDISTPIPRMTYADAMRRFGSDKPDLRFGIELVECAEYFTNTPFRVFQAPYVGAVVMPGGASQPRRQLDAWQEWAKQRGAKGLAYVLIAEDGTLSGPVAKNLSDDERAGLAAHVGAQPGDCVFFGAGEVKSTRALLGAARGEIASKLGLIEDGDWAFTWVVDAPMFEPAAEATASGDVALGHSAWTAVHHAFTSPKPESVDALESDPGSALAYAYDIVCNGNEIGGGSIRIHRRDVQERVFEIMGIGHDEAQEKFGFLLDAFAYGAPPHGGIAFGWDRITALLAGESSIREVIAFPKSGGGVDPLTDAPAAITAQQRKESGIDAKPAPRGGADQNDADQKDAGSTSV
>NZ_CP016594.1|WP_033203546.1|2624737_2628223_+|transglutaminase-family-protein
MTIKVALEHRTVYSFDRPAKIYPHVVRLRPAPHSRTPIEAYSLTVEPGAHFLNWQQDAFSNYLARLVFPEPSTSLGITVSLVADLTAINPFDFFIEEWAEFYGFDYPAELRRDLEIFLRPAGVTEGEFAGAPVHPEIARFAAKHRPAGRTRVIDFLVGLNAAVRDAVGYTVRLEAGVQSPEYTLSSAIGSCRDSAWLLVALLRELGFAARFVSGYLVQLTSDVKALDGPSGPDADFTDLHAWTEVYLPGAGWVGLDPTSGLFAGEGHIPLAATPHPVGAAPITGSTGPCHATLDFTNTVTRFHEDPRVTLPYTAEQWNRVTDLGALVDERMKRNDVRLTMGGEPTFVSIDNQTDPEWRTAADGPHKRLLAGRLAGRLQKAYAPDGLIRRSQGKWYPGEPLPRWQLELLWRSDGLPIWRDPGLLADPWATPEQCAAAIETETHGPDPEITGDAGPARELLTAFAAALGLPAGQVMPAYEDPLVRMRELAAMPPGDPGTDPTLPAARAFAQADMTVDADSTDGEDDESLAPASDSVARRRALIARLDAAVTEPCAHLVPLSRSEDRTAWQSAVWTTRRGRIVLTPGTSPAGLRLPLNSLSWGPAPTLFEADPSARHEDLPADPSTALGHAVRDVDPVQFLPRTALVAEVRGGVVHVFMPPTSTLEEYLAIVELVEDAAAATSTPVVVEGYGPPADPRLVSLSVTPDPGVVEVNIQPTGSFAEQSELLESLYDHARHVRLGTESFDLDGSHGGTGGGNHITLGGVTPADSPMLRRPDLLVSMLTYWQRHPALSYLFSGRFIGTTSQAPRVDEGRESALYELEIAFAEIDRLAVKDAVGGRFDGAPPNPWVTDRALRHLLTDITGNTHRAEFCIDKLYSPDSVRGRLGLLELRAFEMPPHHRMAMVQSLLVRSLVSWFWEKPYRARLIRHGGDLHGKHLLPHYVIADIALVAEELREAGYPFETAWLDPFTEFRFPRLGTVQIRDQEIELRSAIEPWNTLGEESTGTGTARYVDSSVERVQVRVLGGEDDRYLLTCNGFPIPLRATGRTGERVAGIRFRAWQPPSSLHPTITIDTPLTFDLIDTVNGRSVGGATYHVVHPGGRAYDRPPVNAVEAESRRNGRFEAAGHTTGTVDVGLLRERASRQAIDFGVPGVLDLRRARTVLR

Crispr_ID: NZ_CP016594_5

• CRISPR_ID: NZ_CP016594_5
• CRISPR_location: 2822111-2822210
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016594_5

Consensus_repeat	Method
GCGCAGCGAGCGGGGCGACTGGCT	CRISPRCasFinder

spacers of NZ_CP016594_5

>5.1|2822135|52|NZ_CP016594|CRISPRCasFinder
GGCCGTCGCCGGGAGCGCAGCGAGCGGGGCGACTGGCTGGCCGCCGCCGGGT

CRISPR arrays and Neighbor proteins around NZ_CP016594_5

CRISPR arrays

The CRISPR arrays of NZ_CP016594_5

>merge|NZ_CP016594|5|2822111-2822210|CRISPRCasFinder
GCGCAGCGAGCGGGGCGACTGGCTGGCCGTCGCCGGGAGCGCAGCGAGCGGGGCGACTGGCTGGCCGCCGCCGGGTGCGCCGCGAGCGGGGCGACTGGCT

>NZ_CP016594|5|5|2822111-2822210|CRISPRCasFinder
GCGCAGCGAGCGGGGCGACTGGCT	GGCCGTCGCCGGGAGCGCAGCGAGCGGGGCGACTGGCTGGCCGCCGCCGGGT
GCGCCGCGAGCGGGGCGACTGGCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016594.1|WP_004019033.1|2811553_2812714_-|precorrin-3B-synthase	unknown	unknown	gnl|CDD|274131
NZ_CP016594.1|WP_004019031.1|2816762_2817272_+|FxsA-family-protein	unknown	unknown	gnl|CDD|236913
NZ_CP016594.1|WP_110117497.1|2809306_2810905_-|precorrin-3B-C(17)-methyltransferase	unknown	unknown	gnl|CDD|381173
NZ_CP016594.1|WP_033203385.1|2825465_2826473_+|DUF2236-domain-containing-protein	unknown	unknown	gnl|CDD|378343
NZ_CP016594.1|WP_004019020.1|2826493_2827669_-|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223652
NZ_CP016594.1|WP_004019036.1|2808574_2809354_+|cobalt-precorrin-6A-reductase	unknown	unknown	gnl|CDD|236144
NZ_CP016594.1|WP_004019032.1|2812925_2816657_+|cobaltochelatase-subunit-CobN	unknown	unknown	gnl|CDD|235663
NZ_CP016594.1|WP_004019024.1|2823985_2824207_+|DUF3263-domain-containing-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004019028.1|2820679_2821498_+|polyprenol-monophosphomannose-synthase	unknown	unknown	gnl|CDD|133062
NZ_CP016594.1|WP_004019018.1|2829007_2830678_+|phospho-sugar-mutase	unknown	unknown	gnl|CDD|100092
NZ_CP016594.1|WP_004019023.1|2824303_2824627_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004019022.1|2824623_2825349_+|hypothetical-protein	unknown	unknown	gnl|CDD|372667
NZ_CP016594.1|WP_004019030.1|2817376_2819011_+|amidohydrolase	unknown	unknown	gnl|CDD|224490
NZ_CP016594.1|WP_004019017.1|2830703_2831135_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197666
NZ_CP016594.1|WP_004019025.1|2822615_2823767_+|DUF475-domain-containing-protein	unknown	unknown	gnl|CDD|237583
NZ_CP016594.1|WP_004019027.1|2821575_2821920_-|RNA-polymerase-binding-protein-RbpA	unknown	unknown	gnl|CDD|379162
NZ_CP016594.1|WP_004019034.1|2810916_2811540_-|precorrin-8X-methylmutase	unknown	unknown	gnl|CDD|181352
NZ_CP016594.1|WP_004019029.1|2819007_2820696_+|apolipoprotein-N-acyltransferase	unknown	unknown	gnl|CDD|223885
NZ_CP016594.1|WP_033203381.1|2827781_2829011_+|NTP-transferase-domain-containing-protein	unknown	unknown	gnl|CDD|223525
NZ_CP016594.1|WP_033203387.1|2822337_2822619_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016594.1|WP_004019033.1|2811553_2812714_-|precorrin-3B-synthase	gnl|CDD|274131	TIGR02435, Precorrin-3B_synthase, precorrin-3B synthase. An iron-sulfur protein. An oxygen atom from dioxygen is incorporated into the macrocycle at C-20. In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	4.31604e-56
NZ_CP016594.1|WP_004019031.1|2816762_2817272_+|FxsA-family-protein	gnl|CDD|236913	PRK11463, fxsA, phage T7 F exclusion suppressor FxsA; Reviewed.	3.83273e-25
NZ_CP016594.1|WP_110117497.1|2809306_2810905_-|precorrin-3B-C(17)-methyltransferase	gnl|CDD|381173	cd11646, Precorrin_3B_C17_MT, Precorrin-3B C(17)-methyltransferase (also named CobJ or CbiH). Precorrin-3B C(17)-methyltransferase participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. This model includes CobJ of the aerobic pathway and CbiH of the anaerobic pathway, both as stand-alone enzymes and when CobJ or CbiH form part of bifunctional enzymes, such as in Mycobacterium tuberculosis CobIJ where CobJ fuses with a precorrin-2 C(20)-methyltransferase domain, or Bacillus megaterium CbiH60, where CbiH is fused to a nitrite and sulfite reductase-like domain. In the aerobic pathway, once CobG has generated precorrin-3b, CobJ catalyzes the methylation of precorrin-3b at C-17 to form precorrin-4 (the extruded methylated C-20 fragment is left attached as an acyl group at C-1). In the corresponding anaerobic pathway, CbiH carries out this ring contraction, using cobalt-precorrin-3b as a substrate to generate a tetramethylated delta-lactone.	3.35574e-110
NZ_CP016594.1|WP_033203385.1|2825465_2826473_+|DUF2236-domain-containing-protein	gnl|CDD|378343	pfam09995, DUF2236, Uncharacterized protein conserved in bacteria (DUF2236). This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	8.48464e-43
NZ_CP016594.1|WP_004019025.1|2822615_2823767_+|DUF475-domain-containing-protein	gnl|CDD|237583	PRK14013, PRK14013, hypothetical protein; Provisional.	4.57693e-169
NZ_CP016594.1|WP_004019032.1|2812925_2816657_+|cobaltochelatase-subunit-CobN	gnl|CDD|235663	PRK05989, cobN, cobaltochelatase subunit CobN; Reviewed.	0
NZ_CP016594.1|WP_004019020.1|2826493_2827669_-|NAD(P)/FAD-dependent-oxidoreductase	gnl|CDD|223652	COG0579, COG0579, Predicted dehydrogenase [General function prediction only].	6.79785e-95
NZ_CP016594.1|WP_004019028.1|2820679_2821498_+|polyprenol-monophosphomannose-synthase	gnl|CDD|133062	cd06442, DPM1_like, DPM1_like represents putative enzymes similar to eukaryotic DPM1. Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.	7.99903e-95
NZ_CP016594.1|WP_004019018.1|2829007_2830678_+|phospho-sugar-mutase	gnl|CDD|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_CP016594.1|WP_004019022.1|2824623_2825349_+|hypothetical-protein	gnl|CDD|372667	pfam13669, Glyoxalase_4, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	2.72693e-08
NZ_CP016594.1|WP_004019030.1|2817376_2819011_+|amidohydrolase	gnl|CDD|224490	COG1574, COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only].	9.74541e-96
NZ_CP016594.1|WP_004019017.1|2830703_2831135_+|helix-turn-helix-domain-containing-protein	gnl|CDD|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	4.03272e-27
NZ_CP016594.1|WP_004019036.1|2808574_2809354_+|cobalt-precorrin-6A-reductase	gnl|CDD|236144	PRK08057, PRK08057, cobalt-precorrin-6x reductase; Reviewed.	2.95662e-97
NZ_CP016594.1|WP_004019027.1|2821575_2821920_-|RNA-polymerase-binding-protein-RbpA	gnl|CDD|379162	pfam13397, RbpA, RNA polymerase-binding protein. RbpA is a family bacterial RNA polymerase-binding proteins. RbpA acts as a transcription factor by binding to the sigma subunit of RNA polymerase.	1.73782e-49
NZ_CP016594.1|WP_004019034.1|2810916_2811540_-|precorrin-8X-methylmutase	gnl|CDD|181352	PRK08285, cobH, precorrin-8X methylmutase; Reviewed.	1.59484e-116
NZ_CP016594.1|WP_004019029.1|2819007_2820696_+|apolipoprotein-N-acyltransferase	gnl|CDD|223885	COG0815, Lnt, Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane].	2.19713e-100
NZ_CP016594.1|WP_033203381.1|2827781_2829011_+|NTP-transferase-domain-containing-protein	gnl|CDD|223525	COG0448, GlgC, ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism].	1.95151e-107

Protein sequences

>NZ_CP016594.1|WP_004019027.1|2821575_2821920_-|RNA-polymerase-binding-protein-RbpA
MADRVLRGSRLGAVSYETDRDHDLAPRRIVQYRTDNGEIFDVPFADDAEVPSKWPCKNGMEGTILEGAEPEEKKGKPPRTHWDMLLERRSEEELEVLLNERLDLLKQRRKGITN
>NZ_CP016594.1|WP_004019028.1|2820679_2821498_+|polyprenol-monophosphomannose-synthase
MASGIDATAGQRRPDDAPQRVVGADGTGALVVVPTFNERDNLPLIIGRLQDVLPGAHVLVVDDSSPDGTGDVADELARADDAERVHVMHRVEKDGLGKAYLAGFAWGLDRDYAVIVEMDADGSHAPEQLNRLFDAVNDGADLVIGSRYVPGGKLVNWPKRREFLSRGANTYARLALGAGVHDITAGFRAYRRIVLEKIQLDTVESAGYCFQIDLAWRTVRAGFDVREVPITFTEREIGVSKMSGGVMSEAFTMVARWGVQSRLERWGLLRTR
>NZ_CP016594.1|WP_004019029.1|2819007_2820696_+|apolipoprotein-N-acyltransferase
MSPPQVSRSWLAQTGTAVAAGVAMWAAFPPRNWWFLAVLGLGLLFAALYVGTPRVRTAAWIGFVFGLAFFVPLLPWIGVYVGPLPWLALAAILAGYLALFGAIATVTMRLPVPPVWFTLCWVLVEALRSAFPFGGFPWGRTAFSQVDGPLLPLASVLGAPGLSAGVALFGSSVAWLLVVLVRAYRRTRSNDGPTPAPGTDGPVPVAERSSGVVRIATTAVAIALLAPIAAIAATPASLDRNIATSSARIGAIQGNVPRLGLDFNAQRRAVLDNHVRTTMAYGRAIDTGQTEQPDFVLWPENASDISPLDNADAAAEITAASEAVDAPILVGTLIRNPDGRPTNSVLVWDGAKGPVARYDKHIVQPFGEYLPWRPFFRLFSSYADMAGDFRPGTGPTVVDVPGRSGTVTVGVATCWEVAFDRAARQSVREGAQLLFVPTNNATFGRTEMTYQQLAMSQVRAVEHGRAVVVAATSGVSAVIEPDGSISRQSGIFTSDVLTGRLPLHDDMTLATRLGPWPEVLAIIAAVVGLLFALRSRTRFSLRPRRVAARATGDTKELDGIGD
>NZ_CP016594.1|WP_004019030.1|2817376_2819011_+|amidohydrolase
MATQLLLGGAVYSPAAPDATAMAVTDGIVVWVGTDDVGRALHPDAEVIDLGGLFVSPGFVDSHVHLTSTGLGLDGLTLNEASSRTHCLRLVEKAVAAESAHEGGDLIWGLGWDDSTWAGAEPDDGRFPTTTELDAVVGTRPVYLARIDEHSAVASTALRRLIPDLAGAVGYHPEEPLVAEAHHLVRGAARLLVTAAHRERAQRRALDGAAAHGVVAVHENGGPDISGMDDFLALAELDHPVEVRRYWGQAVTDADHARELMSITRADALGGDLFIDGAIGSHTAWLTEPYTDDPHTHGISYLGAEAIRDHLRACTIAGIQAGFHVIGDAATGVVVGALADLADELGTPALARCAHRLEHAEMVTAADAEVLARCGVIASMQPLFDAEWGGPGDLYDARLGAPRAATLNDFAMLARTGVALSFSSDAPVTAIDPWSTIRAAVHHHQPANAISARGAFAATTRGGWRAGGVNDGVTGTLTPGAPASYAVWEVDDLVVAGSHEKVQRWSTDPRSRVPALPDVSPGAELPRCVRTVHRGRTLYDRDAG
>NZ_CP016594.1|WP_004019031.1|2816762_2817272_+|FxsA-family-protein
MALRWFAAYAVLEIAAFVAMVMTLGFGWAVLISLAAVVLGVVVLRWQGRKVFGELQRASRNEVDARAPLADTALVAVSTLLLVIPGVVSTVAGTLLLFPPTRRVMRPVVVAVGARRVATAMDRAGVYATGVYGAGRGATVVEGSVVESDTPGPGSATTPFGTRGLPQGR
>NZ_CP016594.1|WP_004019032.1|2812925_2816657_+|cobaltochelatase-subunit-CobN
MILLLSTSDTDLLTASAAHEENAPSGSAPTEASVSYRGANPSRILVEDIPRLAADADLIVVRILGGVRAWEDGLAAVEATGKPLVVCSGEQQPDPDLMAHSTVPSGVAAQAHDYLAAGGVANLVNLHHFLSDTVLLTGNGFELPQQTPAWGVLERTPTPLPEVRGAHAEPSPLPEVRGAQATSHEGPDAPTIAVLYYRAQHLAGNTRYIAALCDAIEAKGARALPIFCASLRTAPDDLLEMLGTADALVVTVLAAGGATPATASAGGDDEAWNIERLAALDIPILQGLCLTGSRADWEDSDDGLSPLDVATQVAVPEFDGRIITVPFSFKEFDDDGLPWYQPDLERCARVAGIATAHARLRRTPAADKRIAVMLSAYPTKHARIGNAVGLDTPRSLLRLLDAMRAAGYDIGPESGPDAIPGLAEDDSDALIHQIIATGGQDADWLTEETLAANPIRLSARDYRAWFDTLPEGLRSAVTEHWGPAPGDLFVDRTHNPDGDIVIAALTFGNVAIMVQPPRGFGENPVAIYHDPDLPPSHHYLASYRWIAAHDTGFGADAIVHVGKHGNLEWLPGKNLGMSADCGTDAALGDLPLVYPFLVNDPGEGTQAKRRAHAVLVDHLIPPMARAESYGDIARLEQLLDEHANISALDPAKLPAIRQQIWTLLTAAKMDSDLGLTERPDEEVFDDMLLHVDGWLCEIKDVQIRDGLHVLGEPPRDDAEVDLVLAMLRARQLWGGTSALPGLREALGLVEDGSAERGSVDAVEAQARELVAACAKDDWSTEAVAGATAGLPSAVGDVLTFAATEVVPRLRQTTGEVPRVLHALDGGFIPAGPSGSPLRGLINVLPTGRNFYSVDPKAVPSRLAWETGRAMADSLLERYLADHGAYPPSVGLSVWGTSAMRTSGDDVAEVLALLGVMPVWDEMSRRVSSLELIGLEELGRPRIDVTVRISGFFRDAFPHVVTMLDDAVALAAGADDETDEQNFVAAHVRAAMAEHGDRRRAAMRVFGSKPGTYGAGILQLIDSRDWRSDEDLARVYTEWGGYAYGRDLDGVPAVADMRSAYKRIAVAAKNTDTREHDIADSDDYFQYHGGMVATVRALTGSSPEAYIGDSTRPDSVRTRTLSEETSRVFRARVVNPRWISAMQRHGYKGAFEMAATVDYLFGYDATTDVVADWMYEKLTESYVLDETNQQFMQQSNPWALHGIAERLLEAVERDMWREPPAELLDALRNVFLQTEGDIEGRGED
>NZ_CP016594.1|WP_004019033.1|2811553_2812714_-|precorrin-3B-synthase
MNQPARAAADRCPGVFDTHPAADGALARVRLPGGRIRPDQLEELARAAADHADGHLELTVRGNLQLRGITDVEAVAEAVVAAGLAPSSTHDKVRNIELSPLTGRIGGIADARPLAAALDDALRADPAAASLSGRFLFGIDDGRGDIAARRPDACAVIRARTPLAANISIGGVAVGSASGSEAIVRALIAVAAGLGQVVPGAWRVRDLDTDARRRLTDLVASGLDPVIDNDPDTTPSAPGEPIVGWFDQDDGAVLLGAVVELGRLPARLAEFIAAVQAPIVFTPDREILLCDLGEGVAETVVRVLAPMGLIFDAASPWASVSCCVGAPGCASAHAPVRDDLMARVQAGDPVDEREHWVGCARGCGSPAESHLSVEATPDGGYERRRR
>NZ_CP016594.1|WP_004019034.1|2810916_2811540_-|precorrin-8X-methylmutase
MTEYLRDGAAIYRQSFATIRAESDLSAFAPDVATVVVRMIHACGQTDLTRDVIATPGVVAAARGALEAGAPILCDANMVASGITRKRLPADNEVLCHLSEPTLPTLAEQLGTTRTAAALEFWLPRLEGAVVAIGNAPTALFTLLDMIDDGAPRPAAIVGAPVGFVGAVESCAALAERDDLEFITVTGRRGGSAITAAAVNALATPKE
>NZ_CP016594.1|WP_110117497.1|2809306_2810905_-|precorrin-3B-C(17)-methyltransferase
MHSDSSAAGQTSGQGTLYGIGLGPGDSELMTVKAARLITTADVIAYHSARHGNSIARSVAEPYLREGQTEERLMYPVTTETTDHPGGYQGALDDFYTESAERLAVHLRAGRDVVLLAEGDPLFYSSYMHMHKRLSPHFDAEIVPGVTSVSAASAATGVPLVEGEETLTVVPGTASTSELLFRFRSGDAIVVMKLGRTFERVRDALREAGRLDEAYYVERASTTVERVLPAADVNPAEVPYFSILVVPGRRNNPRFEPEPVPGELVVVGLGPGHDSWTTPEVRTELATATDLVGYTTYLKRVTPRPGQRVHASDNRVEAERAEFALDLARRGARVAVVSSGDPGVFAMAAAVAEVAAQPRWHEVPVRVVPGVTAATAVAAAVGAPLGHDFAVISLSDRLKPWSVIERRVRAALGADLVIAIYNPGSASRTWQVGALQHTLTQTVSPDRVVVLGRDVGGPEQQLTITTVADFDPAVVDMRTMIIIGSSATRVVQRAAGPLVFTPRSHRPVDTTDQTADESAEQRLEPVPGGPDL
>NZ_CP016594.1|WP_004019036.1|2808574_2809354_+|cobalt-precorrin-6A-reductase
MTDPGTTDSSPPDDARRILILGGTGEARALASTLSESGIGFISSLAGRVNDPRLPVGPVRIGGFGGSDGLRGWLQSNRIQAVVDATHPFAATITRNAARATADAGLPLLRLRRDPWVPGDSDTWIRVPDLPSAAREVAARGGRVFLTTGRQDVGVFAGIESAWFLIRVVDAPTGALPPHHEVVRSRGPYDHASESRLLRDNDIDMLVTKNSGGPLTSAKLAAAAELGIEVIMVDRPAEPDSAVVSEVGAARDWLEALLG
>NZ_CP016594.1|WP_033203387.1|2822337_2822619_+|hypothetical-protein
MVDSELGRRRKYCKRSCRQRAYEQRTLLEGTSIPDDAVILSSAEAADFGDRMFALRCAAEDLGTAVAERADHDVLAGLTETLLELAREAEKLR
>NZ_CP016594.1|WP_004019025.1|2822615_2823767_+|DUF475-domain-containing-protein
MIGRIFAPSLVVTLVALVVAYLYLGWTGLALCAILGVLEVSLSFDNAVINATILERMSAFWQRMFLTVGVLIAVFGMRLLFPLVIVWITGNLNPVEALDLAMNPPPEGQTHFADGQPSYETILTEAHPQIAAFGGMFLLLLFLNFVLTERPQTWLTWLERPLATLGKLDQLAVVIASLALVLTAEFLAPDEVRATVLIAGILGMVTYVTVDGLSSLFMAEPDADPATENDADSDGAGAEQAGRGRSGPHPVTVATGKAGFFLFLYLELLDASFSFDGVIGAFAITSDPIIIALGLGFIGAMFVRSITIYLVRKGTLGEYRYLEHGAHWAIGALAAILLISIEFEINEVVTGLVGVAFIGASLASSIRANRREARAASPDRLAV
>NZ_CP016594.1|WP_004019024.1|2823985_2824207_+|DUF3263-domain-containing-protein
MDSKQQQMIQFETNWYPLGGGSSRQIGEEFGLTDRDFFSEVDRLVDTDPPSALTASELRRMREVIRRRLWMAR
>NZ_CP016594.1|WP_004019023.1|2824303_2824627_+|hypothetical-protein
MPFSDDDLEAFYRDVEARTAFRDQPRRARRGGVDYPACPTPDKLPFASPADAREGIDRLRRHLVGTSSELRYYECSCGAWHITSSAQLIHRRVPPPAARRRKGKKKR
>NZ_CP016594.1|WP_004019022.1|2824623_2825349_+|hypothetical-protein
MTILPGPHALVDLTSDDPSSTAATYERLLGRKVGTDTDGRRTLAVGNVVLSLRAPSGGSDSHGVYFTVDDVPATRRLLGRRGYPLTDSVLGALGETSPIGMAARPDPVAGPDSDLTGLDHLVFTCDNRDVAVALFAGTFDLDFRLDQPIGQDARQLFFRRGDLIVEVVAAPRPPADPVPSSPVTLWGVAWRSIDVDATHARLTDAGLDLSEIRVGRKKGTRIFTVRHRELATRTVVIGPEA
>NZ_CP016594.1|WP_033203385.1|2825465_2826473_+|DUF2236-domain-containing-protein
MTAVHDERTAIEPETGDSVAAEPLLNHRDDEIELIPPDSLTAKLTGMYTFLPINGAAFVMQVMHPVIGDVVGKYSVFRTDPVGRAIRSADSVLRWTYGGQEALEEGKRLRKLHQPLQMRNAEGKHISALNPEAYAWVIATALPTIETAAPLVLGRHFTLEERRELLRDNRRIAKIVQVPMNNYPETLEEFDEYFDDFIENKLVRHPVALELIDQMRAAPVIPKSVPKALRPAAKKAAATASVPFQNFNYLTTVGVMDPRVREILGLTWTDAEQRHLERIHRNLRFAYRTLPERLTYFPLAYHARRHHDAIQAMKVREKASAAYQYHPKPGDSPQS
>NZ_CP016594.1|WP_004019020.1|2826493_2827669_-|NAD(P)/FAD-dependent-oxidoreductase
MARIRPAEHATTERVEVDCLVVGGGIVGLAVARAFALQGREVVVLEATDSVGTQTTSRSSEVIHAGLYYPAGSLKARLCVGGRRLLTRFCDEHDVSWAQPGKLVVATDDTQRERLDEIHRRGLANGVTDLRPIDVDELRDREPEIDGVAALFSPSTGIVDVDGVVRALRRDLEALGGGIALRSRVIGGHIDRGGITVHTDDGESAVTRTLVNCAGIGAWQVARSLTGFDGPLPPRFLAKGNYFGLSGVRAPFRHLVYPVPADGGLGVHFTMDLGGAARFGPDVEWLDVTAGETATEDELDYAVDDARAAAFERAIRTYWPGLPTAALVPAYAGIRPKVTGPGVAAGDFEIHGPATHGIAGVVNLFGIESPGITSSLAIAEHVVGLVTPPTT
>NZ_CP016594.1|WP_033203381.1|2827781_2829011_+|NTP-transferase-domain-containing-protein
MRYSEVLAIVQAGGRGSRMEVLTDRRAKPALPFAGNYQLIDFPLSNLHHSHIDDVWLCVQYEAETITQIVAGGRPWDLDRTSGGLRVVMPEQTDAAETEDGFATGNADLLYRIRGRIAAHAPAEVIVMSADHVYDFDFRDAIETHRRHGAECTVVTTTCPLDEATQHATVKARRDGTVREFRYKPERATTRTIATEIFVYDPAVLIEGLEYLESRTTESSPKDDTGLGDFGEHLLPWFVDRGKTVAHAMPGYWIDAGRPETYLQAHRDLISGALDVFRGDRPILTNQPQRPAARIETGAVVEDSLVSGGAHVLGTVRRSVLGPGVVVEKGAVVADSVVFGDAVIGAGASVAWSVLDERVRVGPNAVIGGHPRTRPVPTEKITLVGMDTQILRGARVTLGDRVDPGRRIR
>NZ_CP016594.1|WP_004019018.1|2829007_2830678_+|phospho-sugar-mutase
MTTIETARRWRDHDPDPSTRAVLTELIDAADNGDDAAAGDLASRFDGPLAFGTAGLRGEVGAGESRMNVAVVTRATVGLARYLLDTVGPDARVVVGCDARHGSAEFFDAATEVLAAQGLTVFALPPRLPTPVTAHATRSLDCDAGVMITASHNPPADNGYKVYLGGRATDDPGRGVQIISPADGGIADRIAQAPPADQVPRDSAAVIHLDDAIVRTYVQRTAGLRPDSGPSPVRVVLTPLHGVGGEVAREVLRAADIGDVHIVAQQFAPDPDFPTVPFPNPEEPGALDLALDLARDVGADVVIALDPDADRCSVATPGADGRWRQLTGDEIGGLLGEQAASDPARPGDTLACSIVSSRLLDRIAAHHGLRFAATLTGFKWIARTPGLRFGYEEAIGYCTDPDTVRDKDGIGAMVRVISLVEELARDGRTLTDELDHLAGRHGLHATAPFTIRVEDTALIGEMMERLRSTPIDRLAGSPVVENRDLAHGSADLPPTDGILLRTAADDRVVVRPSGTEPKLKCYLEVVLDCPDGVVPHAEASRRLDALGADIAALLQL
>NZ_CP016594.1|WP_004019017.1|2830703_2831135_+|helix-turn-helix-domain-containing-protein
MPRTDSDQRLRDLTLLRQVRDRIDREYAQPLDVEALARGVNMSAGHLSRKFRQTYGESPYSYLMTRRIERAMTLLRRGDLSVTEVCFEVGCSSLGTFSTRFTELVGVPPTVYREQSADATDGIPACLAKNITRPIRNREAQRG

Crispr_ID: NZ_CP016594_6

• CRISPR_ID: NZ_CP016594_6
• CRISPR_location: 2874347-2874498
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016594_6

Consensus_repeat	Method
CGCTCCCTGAGGTGCGAGCGGACGACCCTCTGCCCCCTGAGGTGCGAGCG	CRISPRCasFinder

spacers of NZ_CP016594_6

>6.1|2874397|52|NZ_CP016594|CRISPRCasFinder
CAGCGAGCCACGAAGGGCGACCCTGAGGTGCGAGCGGACGACGCCCAATCTC

CRISPR arrays and Neighbor proteins around NZ_CP016594_6

CRISPR arrays

The CRISPR arrays of NZ_CP016594_6

>merge|NZ_CP016594|6|2874347-2874498|CRISPRCasFinder
CGCTCCCTGAGGTGCGAGCGGACGACCCTCTGCCCCCTGAGGTGCGAGCGCAGCGAGCCACGAAGGGCGACCCTGAGGTGCGAGCGGACGACGCCCAATCTCCGCTCCCTGAGGTGCGAGCGGACGACCCTCTGTCCCCTGAGGTGCGAGCG

>NZ_CP016594|6|6|2874347-2874498|CRISPRCasFinder
CGCTCCCTGAGGTGCGAGCGGACGACCCTCTGCCCCCTGAGGTGCGAGCG	CAGCGAGCCACGAAGGGCGACCCTGAGGTGCGAGCGGACGACGCCCAATCTC
CGCTCCCTGAGGTGCGAGCGGACGACCCTCTGTCCCCTGAGGTGCGAGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016594.1|WP_004019810.1|2863272_2864121_-|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl|CDD|143587
NZ_CP016594.1|WP_033205572.1|2879789_2880020_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004019796.1|2880059_2882300_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|350194
NZ_CP016594.1|WP_004019792.1|2889428_2895800_-|ATP-binding-protein	unknown	unknown	gnl|CDD|379165
NZ_CP016594.1|WP_004019805.1|2868759_2869671_-|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl|CDD|143587
NZ_CP016594.1|WP_033205535.1|2895934_2900512_-|class-I-SAM-dependent-DNA-methyltransferase	unknown	unknown	gnl|CDD|380293
NZ_CP016594.1|WP_033205529.1|2882300_2888675_-|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|224126
NZ_CP016594.1|WP_004019801.1|2872798_2874313_+|DUF3375-domain-containing-protein	unknown	unknown	gnl|CDD|371764
NZ_CP016594.1|WP_004019802.1|2871558_2872674_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|369561
NZ_CP016594.1|WP_004021271.1|2903588_2903765_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004019806.1|2868350_2868767_-|MSMEG_0570-family-nitrogen-starvation-response-protein	unknown	unknown	gnl|CDD|274939
NZ_CP016594.1|WP_004021272.1|2904238_2904730_+|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl|CDD|379275
NZ_CP016594.1|WP_110117498.1|2900515_2903359_-|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|350769
NZ_CP016594.1|WP_004019803.1|2870800_2871487_+|hypothetical-protein	unknown	unknown	gnl|CDD|223505
NZ_CP016594.1|WP_004019804.1|2869726_2870251_-|MSMEG_0572-family-nitrogen-starvation-response-protein	unknown	unknown	gnl|CDD|188559
NZ_CP016594.1|WP_004019799.1|2875286_2878631_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|227250
NZ_CP016594.1|WP_004019809.1|2864185_2865616_-|AIR-synthase	unknown	unknown	gnl|CDD|274944
NZ_CP016594.1|WP_004019807.1|2867082_2868354_-|MSMEG_0569-family-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274942
NZ_CP016594.1|WP_004019808.1|2865617_2866673_-|MSMEG_0568-family-radical-SAM-protein	unknown	unknown	gnl|CDD|274940
NZ_CP016594.1|WP_004019793.1|2888830_2889385_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016594.1|WP_004019810.1|2863272_2864121_-|carbon-nitrogen-hydrolase-family-protein	gnl|CDD|143587	cd07197, nitrilase, Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes. This superfamily (also known as the C-N hydrolase superfamily) contains hydrolases that break carbon-nitrogen bonds; it includes nitrilases, cyanide dihydratases, aliphatic amidases, N-terminal amidases, beta-ureidopropionases, biotinidases, pantotheinase, N-carbamyl-D-amino acid amidohydrolases, the glutaminase domain of glutamine-dependent NAD+ synthetase, apolipoprotein N-acyltransferases, and N-carbamoylputrescine amidohydrolases, among others. These enzymes depend on a Glu-Lys-Cys catalytic triad, and work through a thiol acylenzyme intermediate. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. These oligomers include dimers, tetramers, hexamers, octamers, tetradecamers, octadecamers, as well as variable length helical arrangements and homo-oligomeric spirals. These proteins have roles in vitamin and co-enzyme metabolism, in detoxifying small molecules, in the synthesis of signaling molecules, and in the post-translational modification of proteins. They are used industrially, as biocatalysts in the fine chemical and pharmaceutical industry, in cyanide remediation, and in the treatment of toxic effluent. This superfamily has been classified previously in the literature, based on global and structure-based sequence analysis, into thirteen different enzyme classes (referred to as 1-13). This hierarchy includes those thirteen classes and a few additional subfamilies. A putative distant relative, the plasmid-borne TraB family, has not been included in the hierarchy.	1.17483e-70
NZ_CP016594.1|WP_033205529.1|2882300_2888675_-|DEAD/DEAH-box-helicase	gnl|CDD|224126	COG1205, COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only].	5.35015e-57
NZ_CP016594.1|WP_004019796.1|2880059_2882300_-|AAA-family-ATPase	gnl|CDD|350194	cd18807, SF1_C_UvrD, C-terminal helicase domain of UvrD family helicases. UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.	1.84915e-15
NZ_CP016594.1|WP_004019792.1|2889428_2895800_-|ATP-binding-protein	gnl|CDD|379165	pfam13401, AAA_22, AAA domain.	0.000105353
NZ_CP016594.1|WP_004019805.1|2868759_2869671_-|carbon-nitrogen-hydrolase-family-protein	gnl|CDD|143587	cd07197, nitrilase, Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes. This superfamily (also known as the C-N hydrolase superfamily) contains hydrolases that break carbon-nitrogen bonds; it includes nitrilases, cyanide dihydratases, aliphatic amidases, N-terminal amidases, beta-ureidopropionases, biotinidases, pantotheinase, N-carbamyl-D-amino acid amidohydrolases, the glutaminase domain of glutamine-dependent NAD+ synthetase, apolipoprotein N-acyltransferases, and N-carbamoylputrescine amidohydrolases, among others. These enzymes depend on a Glu-Lys-Cys catalytic triad, and work through a thiol acylenzyme intermediate. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. These oligomers include dimers, tetramers, hexamers, octamers, tetradecamers, octadecamers, as well as variable length helical arrangements and homo-oligomeric spirals. These proteins have roles in vitamin and co-enzyme metabolism, in detoxifying small molecules, in the synthesis of signaling molecules, and in the post-translational modification of proteins. They are used industrially, as biocatalysts in the fine chemical and pharmaceutical industry, in cyanide remediation, and in the treatment of toxic effluent. This superfamily has been classified previously in the literature, based on global and structure-based sequence analysis, into thirteen different enzyme classes (referred to as 1-13). This hierarchy includes those thirteen classes and a few additional subfamilies. A putative distant relative, the plasmid-borne TraB family, has not been included in the hierarchy.	3.75497e-73
NZ_CP016594.1|WP_033205535.1|2895934_2900512_-|class-I-SAM-dependent-DNA-methyltransferase	gnl|CDD|380293	NF033451, BREX_2_MTaseX, BREX-2 system adenine-specific DNA-methyltransferase PglX. This protein, PglX, is a site-specific DNA methyltransferase associated with PGL (phage growth limitation), a type 2 BREX (bacteriophage exclusion) system. The phage resistance appears not be restriction, but does manage to inhibit phage replication.	9.80087e-05
NZ_CP016594.1|WP_004019801.1|2872798_2874313_+|DUF3375-domain-containing-protein	gnl|CDD|371764	pfam11855, DUF3375, Protein of unknown function (DUF3375). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.	2.12523e-103
NZ_CP016594.1|WP_004019802.1|2871558_2872674_-|alpha/beta-hydrolase	gnl|CDD|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	4.75673e-51
NZ_CP016594.1|WP_004019806.1|2868350_2868767_-|MSMEG_0570-family-nitrogen-starvation-response-protein	gnl|CDD|274939	TIGR04042, conserved_hypothetical_protein, MSMEG_0570 family protein. This small protein, about 90 residues long, has no detectable homologs outside the set used to characterize this model. Member proteins serve as markers for an eight-gene region whose overall function is unknown. One member of the cluster is a radical SAM protein with some similarity to enzymes of cofactor biosynthesis, another a glycosyltransferase, several hydrolases or oxidoreductases, and several unknown.	3.9545e-34
NZ_CP016594.1|WP_004021272.1|2904238_2904730_+|nuclear-transport-factor-2-family-protein	gnl|CDD|379275	pfam13577, SnoaL_4, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	5.43922e-22
NZ_CP016594.1|WP_110117498.1|2900515_2903359_-|DEAD/DEAH-box-helicase	gnl|CDD|350769	cd18011, DEXDc_RapA, DEXH-box helicase domain of RapA. In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	1.92821e-61
NZ_CP016594.1|WP_004019803.1|2870800_2871487_+|hypothetical-protein	gnl|CDD|223505	COG0428, COG0428, Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism].	8.31171e-09
NZ_CP016594.1|WP_004019804.1|2869726_2870251_-|MSMEG_0572-family-nitrogen-starvation-response-protein	gnl|CDD|188559	TIGR04044, MSMEG_0572_fam, MSMEG_0572 family protein. This model describes a family of proteins with remote similarity to the DsrE/DsrF-like family (see pfam02635). All members are found in a context of at least seven genes that includes a radical SAM protein, suggesting biosynthesis. The system is sparsely but broadly distributed in bacteria, including Actinobacteria, Proteobacteria, and Cyanobacteria.	4.51428e-92
NZ_CP016594.1|WP_004019799.1|2875286_2878631_+|AAA-family-ATPase	gnl|CDD|227250	COG4913, COG4913, Uncharacterized protein conserved in bacteria [Function unknown].	1.38549e-104
NZ_CP016594.1|WP_004019809.1|2864185_2865616_-|AIR-synthase	gnl|CDD|274944	TIGR04050, MSMEG_0567_Cter, AIR synthase-related protein, MSMEG_0567 C-terminal family. Members of this family include the C-terminal region of MSMEG_0567 from Mycobacterium smegmatis, where the N-terminal is a GNAT family N-acetyltransferase, and resemble the full length of sll0787 from Synechocystis sp. PCC 6803. The conserved cluster that contains these is found broadly (Cyanobacteria, Proteobacteria, Actinobacteria) in about 8 percent of genomes and appears to be biosynthetic. The product is unkown. [Unknown function, Enzymes of unknown specificity].	1.15185e-137
NZ_CP016594.1|WP_004019807.1|2867082_2868354_-|MSMEG_0569-family-flavin-dependent-oxidoreductase	gnl|CDD|274942	TIGR04046, predicted_flavoprotein_involved_in_K+_transport, flavin-dependent oxidoreductase, MSMEG_0569 family. Members of this protein family belong to a conserved seven-gene biosynthetic cluster found sparsely in Cyanobacteria, Proteobacteria, and Actinobacteria. Distant homologies to characterized proteins suggest that members are enzymes dependent on a flavinoid cofactor.	0
NZ_CP016594.1|WP_004019808.1|2865617_2866673_-|MSMEG_0568-family-radical-SAM-protein	gnl|CDD|274940	TIGR04043, hypothetical_protein_WH5701_02349, radical SAM protein, MSMEG_0568 family. Members of this protein family are radical SAM proteins related to MSMEG_0568 from Mycobacterium smegmatis. Members occur within 8-gene operons in species as diverse as M. smegmatis, Rhizobium leguminosarum, Synechococcus elongatus, and Sorangium cellulosum. The function of the operon is unknown, but similarity of MSMEG_0568 to some cofactor biosynthesis radical SAM proteins suggests a similar biosynthetic function. [Unknown function, Enzymes of unknown specificity].	0

Protein sequences

>NZ_CP016594.1|WP_004019801.1|2872798_2874313_+|DUF3375-domain-containing-protein
MEFSAFPAPVEAPGTSSGSESAQVTLTDAWESNRSIQKSAVGRLFAATNSALYVTLMERHLDYGAKLSETELTVRLDRDLADLDLTDQATGLELVKLWARQGWLHRVTDTTDPHAPNLCHLTSEARSVLDFMRRQRREDSIATGGSITGIAAELRRVAGQVSNDPDQIRSEIEAQMSDLDAELADLDAGRRPPVDLRVAEDAARTIGYQMEQIISDIGQYGTMLDRITTALLDDPGDSDLAYRDRQRQLFDDYEALLDSPQSASYQAFSHLIQDPERRARLKSDIETIIDSFPGMDAGLRSVMDNFFGLVTQQMAEVGRTRQRCARRIRRFVASGTLEQSRGLARQLNDALATANELLKTSLADRRIGYELPLAAPTVNSIGRLAFEIREHVPPAPALPAAVDADLTSFASLSGQVDTTELTDTVNAAVATGPVALADVIEGLEEPYLAHVIVLWSWASKQQAAGEKVPMTTVRFRSLIGDDHAIEVPDLTFTEPIPTAEVDAE
>NZ_CP016594.1|WP_004019802.1|2871558_2872674_-|alpha/beta-hydrolase
MVMADRPEVQTASAPVTALTVVGLAQSMVNGLARVPFRKPWSGPSGLLDNLGQSVTRQTIRAFMGYSMGLPIEEFRSMEKILDDVCRVVMPPFVELTDGVELTDDVVGGVPGLWCRAKASSDAYVDDCDDKQEIGATILYLHGGGYIGTSPMMYSAFASSLVRISGHEVFIADYRMAPEFPFPAGVHDAADVYRGLLGRGVDPDHIIVAGDSGGGGLAASLVAYLRDHDLPRPGALALFSPEIDLDLDHPSITDNAPYDILPWSIPVTPYLHGVQPNDARVSPINGEPDPSWFPPTFVCWGGSEMFRDGIRDFAARLETSEVPTHAIEEPGMFHVFPILMPWAEASKRVFRALSELADGHVAADPEAAQTH
>NZ_CP016594.1|WP_004019803.1|2870800_2871487_+|hypothetical-protein
MLTAVLYGLATAIPIAVGAAIGLRWNLPNPILATLMAFGAGTMIAAVSTELFEPAFTQAGTGVAAVALFSGTAVYVVADRLVETKLGSSAIGPALMIGVFLDGVPENTALGVSLTAGGSLVLVVAIAVGNVPEAVSGASLMRREHDASGRSALAMWTFTAVVLVAVTVGGYAMADAIPSTAISVVQAFAGGATLGVLANSLMPEAYREGGWWVGLATAGGFLLAFVLG
>NZ_CP016594.1|WP_004019804.1|2869726_2870251_-|MSMEG_0572-family-nitrogen-starvation-response-protein
MPSFDETITENIAASLAEIPHPSLPKGSNIYGGTKIFPDYQAENGESYFTLVHGIAHESSVSFVAVLQATRALRKGFESAMYFYGPGAINCLATRGFPTTGDSGFPGEQNINNSLETFISEGGTVFCCRFGLALHGGREEDLIEGVIPAHPLDVQDALIHYARKGAIINSTYMV
>NZ_CP016594.1|WP_004019805.1|2868759_2869671_-|carbon-nitrogen-hydrolase-family-protein
MTTIGTVAANFTRDLEQNYATIEQYVAEARTRGVDFLVFPEAAIGGYLSSLGNHGDTRKNSTRSLPPAISLDGPEIARVQSIVGDLVVAIGFCELGEDGETRYNAAAVLDGTRIYGSYRKVHQPLGENMSYSSGTGYDVFDTPVGRIGLQICYDKAFPEAARIMALKGAEIIASLSAWPAARTATAANLQDDRWTYRFNLFDTARALENQVFWVAANQSGTFGSLRYVGNAKIVDPGGNILDTTLLGSGLAVADVDIAESFTAMRAGMFHLRDRRPEVYGMLVEADTDPAASTAFAWRDLAHA
>NZ_CP016594.1|WP_004019806.1|2868350_2868767_-|MSMEG_0570-family-nitrogen-starvation-response-protein
MPEMTVQVRWPDGLLRQYYSPSLVLHDHLAPGTYRVDDFRSRATTALDEASARVRAKYGFVCTSAAASAEEIALDAARHADCAAVEVVSMYPPLPGAEVASTRGVASLRPGSTSSGDGAEARGRPGSTSSGTSSEELS
>NZ_CP016594.1|WP_004019807.1|2867082_2868354_-|MSMEG_0569-family-flavin-dependent-oxidoreductase
MNAHVPVVVIGGGQAGLSVSWYLGQADVEHLVVEADTAVHAWADKRWDNFTLVTPNWHCKLPGYTYDGPDPDGFMTRDEVVEWLKGWLETFEPPLVEHTKVTRLQRLSGDRFELTLEGADGMRSLTCDQAVIATGGYPLPVVPPFASSLDPAVHQVHSEEYFNPEQLPDGAVLVVGSGQSGTQIAEDLHLAGRQVHLAIGNAPRVARFYRGRDCMTWLSDMGLYDTPTQEYPGGRAAQEKTNHYVTGRDGGRDIDLRRFAAEGMKLYGVLTDGKDSTLRFASTLTAALDRADAVYNSICGDIDRHIEKLGIEAPEASRYEPVWAPEVDPTELDLAAEGVTSIIWAIGYRPDYRWIEASAFDGGGRPMQTRGITEVPGLSFVGLPWMHTWGSGRFLGIDRDARYVAEHVVEAVCDRRSQLIVAQ
>NZ_CP016594.1|WP_004019808.1|2865617_2866673_-|MSMEG_0568-family-radical-SAM-protein
MTVSTRVDLALLGIRGEPPVQRSGGAGPSDDGHLMVDGLHAAIPRNPQSPFVFDGDRVLYDGVDIGVEVSAIGRPRFYDLQTADGVSYEKIARLHGRNVLATTVLQTCIRYAEDQRCRFCSIEESLKSGSTIAVKKPEQLAEVARAAVDLDGVTNMVMTTGTSGGRDRGARHLARCVRAIKAAVPELPIQVQCEPPADLAVLTELRDAGADAIGIHVESLDDDVRRRWMPGKSTVPMSEYRAAWAEAVRVFGRNQVSTYLLVGLGEDTDEMIAGAKELADMGVYPFIVPFRRHAGTLAVDVDNAPAPDPTIVEKISREVAGHLSFIGMSGSDQRAGCAACGACSVLPTVGG
>NZ_CP016594.1|WP_004019809.1|2864185_2865616_-|AIR-synthase
MLSRGELSILSGLPRTTPRSEFLITVADRPRDHAAYRALRHREFVERQALFERTDLDDTDEDPRTTVLVATLADGTIAGGVRIAPTPWAGSVHADIGWWFGSRLVVADPGLAGGIGAALVRAACAHVEQLGALRFDATVQDRYAPMFSRLGWLDRGPGPRIEGRSHREMRYPLDRVQRTVDGTKAVLADALAPFANMPGGLGAAGFRGDDGVPLPGTDVIAACDAIIPSMIERDPEWAGWCSVLVNINDLGAMGAHPLGLLDAVGAPTTSHLTRIIRGISSAAAAWRTPVLGGHTQVGVPSALSVTALGTTSTPLRAGGGAVGDTVTLHADLGGSWRPGYHDRQWDSTSSRSSDELCAMASHLATVRPASAKDVSMAGIVGTLGMLAEASGTGAELEVTAVPRPGDASMGGWLTCFPGYAMLSTDRAGARRAVPTPAPVTTADCGRLTAEPGVRLRWPDGETTVAVASTVTGLGAA
>NZ_CP016594.1|WP_004019810.1|2863272_2864121_-|carbon-nitrogen-hydrolase-family-protein
MRTVTLGALAAHFGRDVERGVAKAVGIVESAATDGVDLLVFPDASLGGYLGDLREPDPTELPPALQPDGPELAAIAAAAGDMTVCIGYTEAVGEQRFNTAVCLSGDGILGTHRKVHQPAGEALAYAAGDSFDAFDTPVGRIGMLIDYDKTFPESARTLALDGARIIAALSAWPASVTDRAARLPADRQSRLFDLYDSARAAENQVFVVSSNQTGVMGSLRFLGQAKVVGPGGDILATTRSKGGMATVTVDVDAEVDRARRVLSHLAELRPDTYRSTMPAEQR
>NZ_CP016594.1|WP_004019799.1|2875286_2878631_+|AAA-family-ATPase
MSGQVDQYHLSRLQLINWGVFDGYHSIPFSPNGSLITGSSGSGKSSLLDAISLAFLPDHRRNFNASGDATAAGSSSGKRTVGKYVRGAWGERRDGTNAHREIMYLRGTGPAWAAISVTYTSSSGEAITGLVLKWLAAGKMTDAHSSYFIYDGDADIVEVCNEWAASNYNSAKFRDRGWRGGPGEGKYLSTLYSLIGIRGSDAAQQLLGKAKSLKSVGGLAQFVREFMLDAPTSIVGIADALDQIDPLVEARELLDVARRKRTILGNIEEVHERYAGEAATFSVLDTIDNTTIRSYVNNLRIHNAQPEVADLDDQITRLDGDLAALTTQHDQLRQDHSLLLSRIATSTGDLAPLREQLGGAQKLSTEVTARRNAYEDKVSALGFTPPTRAEGFWLLREELTEEAAKIDGQLDAGRAHYAEALASEVAARTRRDAAQEELGRVENAGSALPRTEHEMRRVIAHALQIDESELRYVAELVELDPDEERWRLAVEKVLRNVGLRLLVPDKHFRAALRFVNSHDMRGRIQLHQAETRSMPVVEPGTLASKLRPVDASHPCAAEAMTVLSKLGNHMCVDSPGEFSQYAKAVTEHGLRKDSAKLAVKDDRHQLRRSQYIFVGDVASKIAALRDELEYEERAFEDARQDCAELDRERSAKERRRDAYRRVCEQFTQWNEIDVDSVDDRVDQLTDQYDLLIEENPDVEALQRKAEDLWEQVRNAISQAALVKDKIARQDSRRTQLLDLIDRLKPEDVPAQAEKTLDGFREDLSATLDVLNPEPYRQEIVKAASRERDRMRSDARRSRDELARILDTYDEEFPDAIPNDSDDFDERLHDYVAVCRRIDERELPAAYERMRRLITEQAPGAILGLHMAADAEERRIVEQIERVNTGLGAVAFNRGTRLRLRPGRKKLAAVEELTEKARQISNRATAVSFGDEQAILEQYSDILLLRERLAGNTPEDRQWTRDALDVRNRFDFYCEEHDAESGETIRTYSNAGDNSGGEQEKLMAFCLAGALSFNLASPHGNDNRPIFAQLMLDEAFSKSDPQFAQQALSAFRKFGFQLIIVATVQNTSTIQPYVDNVVMVSKTEAGPELRPVATATSTGIKAFSELRRSGSQLPV
>NZ_CP016594.1|WP_033205572.1|2879789_2880020_-|hypothetical-protein
MALIRSLERGKGGGRPPQSEVDGTYVVVDDPDRGKILKITTYGSDMRKSGPKPSQVIELDAETAQKLVEIIRRDLI
>NZ_CP016594.1|WP_004019796.1|2880059_2882300_-|AAA-family-ATPase
MANLVIASNTKAMKKLDKTIKDKVWAFIEKLSADHTAPGLHIEPLNGAIDPRVRTGRVDLNFRAILFKVDDKLGDDPTFIYMGTWPHDDANKLAERSQLRVNPINGVLEGIIGELDGEDDRKKRTVVPDPKGELDRAVRAEAKPYLAERFSLSDLTERLGLDSELAERALAASSEDVLVDIAANAVGWQGSALLDLATGLHIDTIREKHGFTETDVDSDLDEDQKILKALEQPASKMQFTFVEDDEELRRIIEGGDFAAWRTFLHPEQRKYVAKDFSGPFRLSGGAGTGKTVVAIHRARHLANLNPDARIVLTTYNRTLAADLKAALKTLDPKVVLAERLGERGVYVSGIDALGNSVLSHAGDIAGAAERVLGYRGAELTHNRTNSDKVWRDVVQSVSSGLDTKLATPGFLENEYVSVVLANRTTTLEQYAKVPRPGRGVRLSRPQRIAVWKLVEAFRRQERVDGSLSFPEVLSVAAEHLRLRAESEHGFVADHVLVDEAQDLHAAHWALLRALVAEGRNDLFIAEDSHQRIYGQPVVLSKFGIKIVGRARRLTLNYRTTAQNLHFAVSILSGAEYKDLEQGEESTDEYRSARLGPNPRLVECSSAGDELDRVAELVQAWIDEGVDKSTIAVLTRGQNDRSQFVRALGERGVEARALDSNPASSGYVQVLTMHRSKGMEFSRVVLAGVDAGHVPSAATLRSVPEEEKAEALLRERSLLYVAASRARDELVVTWSGTRSELLAANAV
>NZ_CP016594.1|WP_033205529.1|2882300_2888675_-|DEAD/DEAH-box-helicase
MGALLPTLQANHLHEGLTDYLATTFALTDPDAQGALSDFVGHPDTGMFKGPYVRLRLPFAPAGGNWGMHLDWWPTGFTPYGHQAAAFERLSTKFHKRPQPTLVTTGTGSGKTEAFLYPILDHVLRAKAAGVTGMKALILYPMNALANDQAERLAHLIAAHPELSGVSAGLYTGEQSTGGRTKVTDEGLITDRSLMHSAPPDILLTNYKMLDHLLLHPDRADIWRLSADSLKYAVLDEFHTYDGAQGTDVAMLLRRLGLTVKAHWTDTSPVTDEDRARPLGRITPVATSATLGSKAEPTAMLDFAHTVFGEQFDADAVIGETRLTAAAWLADRDTGLDRLYRPIAPAIVDAAGRLDEFAGGSPTNAALTSAVLAELFERAEVFERTELFAAADDLDTDRRLTPTDLRSLTPVEQLHLLKAHPILARLLDRAVDAISLADLADALFDVPATERDTRRVRAAQQRFLDYLFAALSHLRAETGRDALNVDVHLWIRELSRIDRAVASNTTYRWSDDGVHEDGDVMHLPAVFCRHCGRSGWGARLAPTGHTLDVTDDSIRADHAAGASRFRALLSAPAEALLAATRPDEEIEGLRWFRIDDREISDTPPDPDSTDELEGKVLPVLTLTGDNVEENSKNDMCPACGAADGIRFLGSAVATQLSVTLSNLFGDARLDADEKKALMFTDSVQDAAHRAGFVQARSHTLSLRSTLRSAIGDGALTLPELCEAVITRAGDDPARRYHLLAPDIVDHDEFTPFWKPDATAASRKKAAAKVFRRLEFDIDLEFGLQSRLGRTLELTGSAVAEVDLGGSERPVRLGRAALNATEHQLTLTPPDAAAIIRWVRGTVERVRTRGAIHHPWLRKYVEKDANRRWVWGARPKGEGMPAFPKGRPAPAFPAVGSRSVPEGFDAITAASSWYARWASQCLGVSPFDGSFLARSLFSVLAEQRVLTAVLTEAGLTAYGLSPASVIVSAPADDDLAAGRHLLVCSVCQTPTPGSVTVVDELDGAPCLLVRCLGTLARAPKAQNFYRRLYDTAEMKRVVAREHTSLLPTATRLGYETAFKRGGADPQAPNVLVATPTLEMGIDIGDLSTVMLGSLPRTVSSYLQRVGRAGRLTGNSLVLAFVRGRGEHLPKLYDPTSVIQGDVRPPATFLTAEEILQRQYIAHVIDRLARDPNTLAPRGARAVLVSFDPGSWMADLLAAVSTDADALVDGFLAQFNDVLDDEARGSLRAWATPGPDGSPFELVDDLQEAVHRWNRDLTELTARRAAVEAEMPEFERRASSPAATDDDLRDLRTAKGSLRLLGGQIHDLTDDYWISVLERYGVLPNYTLLDDSVTLDVGVTWIDPDTNQYMGEATSYQRGSRVALTELAPGATFYAQGLAARIDAVDLGAGESNIHTWRLCPQCGWAGITLAGEEPPSVTACPRCETSAIADVSQQLQVVEMARVSAEVRRDEASINDSRDERHKESFTVVTAADIDQVNVDRAWFVGELEFGAEYLRRIDVRWLNMGRRTSQGGTRTIAGQETTTGLFRVCSSCGQLDRAAGRNSRYEHRSWCRYRNAATEHVREIALARTLRTQGVLLHLPQALEYDPFAHPSLSAAILLGLRQVIGGSPEHLDVATIPDALHAPSQRALLIHDTVPGGTGYLAEFADPAKVWAVLDAARTVVRHCDCAEHDRLACHKCLLPFAPPHDLDKVSRKTAVRILDDLLAVDGDAEPNRETWIADVTESAPSRPIGSEESPLEKEFYVAFIERLRAMGATVKETPGTYGPSATIVLPGRKIRTWKLTPQVHMVKSKPDFELATTDPEIPRIAIFADGRRFHAMSGCNRVADDAAKRAVLRDSGHLVWSFGHEDLQRFKDKSAPVPSWFTEQAASKIMAAGNLRPAVVKLLSADPITTLLSFLTDPDLDAWEQVSRWVPMMFVGGGTRAKGDGDSVGARALDLLDGKTPHFGDGLDMCWSYIDGPLVAAATMRPSTRTTNAVLALDDRDDRLEVLDGHAWKEWLRLSNWLGLSRNHRITTRSLLSQNDAAPTSAPTSTDLTHDWRVLFDATVSDAEKQLVLALAAANVPVPELGYETADGNVVDFAWADRGIGVLLDPDDETTHTMSDAGWTMFPPDAETIATAIRNGVS
>NZ_CP016594.1|WP_004019793.1|2888830_2889385_-|hypothetical-protein
MACRVAELISVAEMDAAARGEATDLILRLWERRSSWPHGWPTESIARALHWFDKPGRSVANVDGALSPWPHKLAEIQTLLKSEFELWMMIAVNSENILPDSGNEELGALELLDGYLNDDEAEYSRLLRSLRIEQKSTRTSKFAGLNPKELANQVREEIEDLSTRRKAAFEAAYATLYPDEEVEG
>NZ_CP016594.1|WP_004019792.1|2889428_2895800_-|ATP-binding-protein
MAVYVNAAMAELPGAPESNAGDEFHVLWAVGRALNMLNQRNNLTLIVMEGLSPIDEVTSSKHLLLGADLTEYHGGNTFDSADSVIVSQLKHSHRKPNQTWTASRLAQKGSRGQDGVIARLSDLFRHFRSIAEREQVLSKLSIRLVSNQPISSSLETLLAKVSATLDQSPARPRMTTLQRGLSKKEIADLEKIKAATRLNTSEFGDFLRVLSLDELGADPRWMQWDQIVATIGKHVLIGPSVGARALYDLVRRQALPEADPLRLTPEQILAELGASRHSSLFPLPPRLKMPQLVIPTPDADRITTAILSGIQHVVAHGDAGVGKTTTVALLENSLPTGSAVISYDCFGNGEYLSPTESRHLARPALTQIINEIAFRYGTPILIPGNEDEFSIWQHLRDILAAASTGLEAHDGHLVIAIDAADNAAIAGRHRGHSVFLQDLWLVPLPPKVHIVATCRTHRRTSISAPESAREIELSGFDLDASAIHLRTRFPSATDTQCRRFHERTTGNARSQFYVLDSDRPDAPTTVGDAITRSDITPQQIFDDLLSAATMESQDPATSELLLANLISLSRPASIETLAGASGLEISDAESFCHGLIPGVVVEGHTVSFRDEDFEAHLRDKVSSEACTAAHARLASYFMSRRTSDTLAAISCAEHLYLAGRPNDLIRLAVDEGQPEIVLDPVARLQSYFRRLELGMKVANQPHQRIDVVKLTILAASASTSNNAVTTIVRKRPDLAITYGDATAVARIYEGSHSDPWRGSLHMRLASLRARAGDAEGAIEELRLSDAWIHRWSRLDQHERHDWVLGAEDVAAGAEAIFILYGAEAASDEIRRWQPFDFAMECATKLVESLSSIVPAYDLTCIISELAIPAPTKAQLLAALFVRGAVGATESIRLVAEASLTNPADPERRHEPWVASFAELIASSTRDTNLLLRWIAVYSPIFPSHAPNEWTGLDDWGPVVRVRCLTAVAESRSIDVSEFVPPRMRDNEDDSPRDREEKDEQRRRLQTVVSVSLDVLLARATVWLLDVPISDASKPVLERIATLRSRPLHNDSPDTTKQWAVHAVDVLAGAIGDATETATKLMDEIWARDAGLGMHLSPALAGRLIIHEKYRSTALSWLDRAAQATASSVEPATARADRLLDLADIADEHAPDMAAGYYRAAVQAAEGLDDEGAGVLRFHAAVSQGSYDLSDSRTPGIAERLARALERFQPFVSDPERLPWRETAHAVAQLHPPAGLALLSRWEQQDLLPLWVSLPSVLSTVANTFISPQKVLPLLLLSGEDHFPLLIALDIVDSIRIGHNRRMLASALRWLVSYICRDIAPGDRVDAAPAVVEWAKKHGLQDTEPIQRLVVLVDYSKDFPHEHQVPHHHSDDSNSAKVRAVVDKASACPIGDLKSAMDELGEAWARGNDIESFLTNMAASIVPADRTRLLRAISDIPAGHRIWRFHTRSLFATIHTLLNQWNLMPAVNSWATDELPFLIRAHVQDIVAYEQTADMTLPIIASMPGLSDATGIIIEGIGPLLSELSATQLYSIAQGVAITLPTDDRLNVLDWSLAQLEEAPVRTPSISLDPIDVLSRFLYSLFGHPDKHVRWRAAHSARQILSDDPTDLPQLWSRFKEQSAGPFGPDTGTFFALSAQSWLLMLIDRMAADRPSTVESLTRELAEIALDQSFPHAAHRELARRAALSVFEFLGPGDQSTSLIEDLNLANKPQSSRLERRIGGRGGAFDNRDNRRFRFNSLDTVPYWFGPLANQFGISCDNVCDRAERWIVDNLLFTDESVSTEPALLTQRYRYTEFRNDHGELPQVEDLQTYLEYHAMMLVAGELVDLGTSVVVPTWDDPDDPWEVWISDHVPSPTGWMIEKRAPAPVTPASFGVVPSIDRWRDRNPSDFDHELGLDTSTAAIVVDSYCEVFASKRHGSTWVASALVSPSNAAALLVALQICSDPTDFRLPPEDFAWSNQFEVNDGQFQLRGWVQEKQRHNLGPEKHDPLRRIDDTFSRPGTLFTETLNLKSLNMGRDLVNTDGNLSAWNSQWSDLPTSTSNSGHTTTTQGRQTWVRLDELLTFMEQIGMDVIFEVRIARQFDGRISTNDGGDGNYEPGESRIYLLRRGGKLETLDGSRELGENYR
>NZ_CP016594.1|WP_033205535.1|2895934_2900512_-|class-I-SAM-dependent-DNA-methyltransferase
MASFDSIVIGEDWISEHYFTTDSAKESFHGKVLELRKLWDAEKKEGRTTVRDDLLASTTELQTALAALAENPDAAPEAHALTRTTFGYPAVLSTFTAERAGSELEIPDSKLDGVASVLFLQAVPVASIEDLLDPETGVLIAPAVEDGKPIESASKAVSAAFRSDAPPAFVVVQAGQWLMLAEAERWAEGRYLAVDLLVVAERRHEAKGGEIDRVAAMFGKQALLPDVDGDVWWTGVLEDSVKHTVGVSKDLREGIRLSIEIIANEVVKRRDAQGMTLDGIDGQDLAKHSLRFLYRILFLLYAEASPEMRVLPTGAAEYEEGYGLDRLRELTLTELVSEQSRTGTHLYESLATLFRLVDRGHSPAVRDDVADDPAPGLEFQPLRADLFKPESTALIDEVGLGNEATQRVLKHLLLSKESKGRRGADRGFISYAELGINQLGAVYEGLMSYTGFFAEEDLYEVAKNGDPEKGSWVVPTNRSDHLDPKDFVRKVDEATGEEKPVLHEQGTFVFRLAGRERQQSASYYTPEVLTKFVVSQALEELLDQNDERTTPDQILELTICEPALGSGAFAIEAVRQLAAEYLKRKQEDLGELIDADQYPVELQKVKAHIALHQVYGVDLNATAVELAEISLWLDTMVAGLQAPWFGLHLRRGNSLIGARRSVYAPSLLAKKQWLKTSAKDVPLGEEIGAGIHHFLLPSEGWGAVIDTAEAKTYALEMREELRLWRNEIRKSPSKAIVKRLQALAQRVETLWEFTLRRLTIAESEIRRDIHLWGSEPVDHTSAVTREEIERVLSNPNGAYQRLRRALDAWCAIWSWPLTTGVEPPDWDQWVGGLEAVLGVPVKETAAERRGQLSIGRDTSWQELGFAEENDLLLSRAMAVGHAYHQFPWLGVAQEISERQGFFHWELDFAPVFARGGFDLQVGNPPWVRPDWDEAGVLAEFDPWWQLSDKAAEPVKQQKREKTLTQAGVLAEYLDERADQTGMKDHLGSGVDRPVLTGLQPDLYRCFMERTWRSMATDGVVGLIHPESHFTEVRAKGLRHETYRRLRRHWQFKNELSLFEIDHHNVFGIHVYGSDSDVRFLHGAALYHPDTVDRSFHHDGSGSAPGMKDDAGRWDLRPHAERIITVETAQLATWAALIDEPGTPPTEARMLYPVNQSSAEVLEKIAAAPRLASDLEFEWTSGWHESADRRRGLFESRSSVPARWEDAILQGPHITVATPLFKQPNESMRNRLDTKLIDLDAVPESFVPRTSYQIAKPYAQYIAEYPHWNGEASSDYARLAWREMAEPGNLRTLHTALLPPGPTHVHAVQSFTLPEHNRELALLAGVSHSVVADFMVKVTGGAHIKASVWRMLPTPRHHHLEQQLILRTLRLNCLVRPYSQLWKELYATDWQHNSWVPDIGIDYAGRTGLGDIGPEWEWATPLRRAADRRQALVEIDAIVAVMLGITAEELLTIYRTQFPVLQKYEREALYDATGRQLPTKLASEYRKKGSLKPADLTVDGITYQEPFVGVDRERDIELAHKHFSAV
>NZ_CP016594.1|WP_110117498.1|2900515_2903359_-|DEAD/DEAH-box-helicase
MVRDEEWLVTSAEQGSDGWLIKGRGLTELVKDTTATFYSSLDKIEVQDPRNAEVVADASSGYRDSRLWLEALLRKTPFPYGDQTLTVSTQMLADSLGYQRAAVAKALDPQHIRPRILIADAVGLGKTLEIGMILSELVRRGRGERILIVTPKHVLEQMQHELWCRFALPFVRLDSAGIQKVRQKLPATRNPFTYFKRAIISIDTLKSPRYKAHLQRQHWDAVVIDESHNLTNVGTQNNELARVLAPNTEALILASATPHNGKEESFAELLRLLDPTAVAADGSFTKDDVVSLLIRRHRHHPEVAAEVGSDWAERAEPVHKLVTPSPAEDAVAQELSQTWLHPQSGRAPYSGETKALFPWTLAKAFLSSPAALAESIKQRLGKLDPHVPAQATELAALTTLDELNAQALNESAGKQAALVQRLKEIGVGAKSSTRAVVFAERVATLRWLTEHLPKQLGLKPENVAMLHGGLSDVEQQEIVDSFKLETSPIRVLVTGDVASEGVNLHAQCHHLIHFDIPWSLIRIEQRNGRVDRYGQKHPPVISSLILEPSDPDFSGDLRVLSRLLERENQAHGTLGDVASLMGKHSVTDEENAIRDVLVGKSTLDEQIRDIDDVADGDDLDAFFAQFDLDETEDDAPANALPQAPRQSLYADDLTFLDEALKAAFHDVPHAKPEAGGVGWTVHANHAVAELTPPRDLRQRLGQLPQNYLQHGKVLERLTLATSPEVGNAQLAAAKEGKGVANTTWPEAHFLGPLHPVLDWASDRALSALGRNQIFVIRGDVDAPTVLLMGTLMNRRGQLISRVFSTAEFPNPNNPSFCVVETLADLDFLTTATGLRPGSANPGAVADAERYRALVPIAVVEATTAMHLVLGAQERTATERLATWRKRADRWHSGAEQLELVAGQRKKVDTLSRRIAEEQRLAESLAPTQQLVRPLLFIVPAQNSGKDQ
>NZ_CP016594.1|WP_004021271.1|2903588_2903765_+|hypothetical-protein
MGSYLADQASDEEYRIREALKGVGLFFELNFDEDELRRTQEHFGRLVARELEPARGSV
>NZ_CP016594.1|WP_004021272.1|2904238_2904730_+|nuclear-transport-factor-2-family-protein
MTTDSEHDHVAAIERLKYRYWRASDAKDADAFRGCFVRDGARIDYGPMGTCDDADALTDIFRRVALHKVDGRFAILDMHHGMHPDITITSETTATGRWSLRFRQVNLLDRTETVMVGEYDDEYVVEDGEWKIAASKLTERWRMRQPLSPDVEITEGSFGSADG

Crispr_ID: NZ_CP016594_7

• CRISPR_ID: NZ_CP016594_7
• CRISPR_location: 3334015-3334122
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016594_7

Consensus_repeat	Method
CGTCGCTAACGCTCCTCGCACCTCAG	CRISPRCasFinder

spacers of NZ_CP016594_7

>7.1|3334041|56|NZ_CP016594|CRISPRCasFinder
GGAGCAGGATGGGACTGTCGCTTTCGCTCCTCACACCTCAGGGAGCAGGGTGGGAC

CRISPR arrays and Neighbor proteins around NZ_CP016594_7

CRISPR arrays

The CRISPR arrays of NZ_CP016594_7

>merge|NZ_CP016594|7|3334015-3334122|CRISPRCasFinder
CGTCGCTAACGCTCCTCGCACCTCAGGGAGCAGGATGGGACTGTCGCTTTCGCTCCTCACACCTCAGGGAGCAGGGTGGGACCGTCGCCAACGCTCCTCGCACCTCAG

>NZ_CP016594|7|7|3334015-3334122|CRISPRCasFinder
CGTCGCTAACGCTCCTCGCACCTCAG	GGAGCAGGATGGGACTGTCGCTTTCGCTCCTCACACCTCAGGGAGCAGGGTGGGAC
CGTCGCCAACGCTCCTCGCACCTCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016594.1|WP_004019880.1|3327297_3329241_-|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl|CDD|236101
NZ_CP016594.1|WP_004019881.1|3326546_3327296_-|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	unknown	unknown	gnl|CDD|237086
NZ_CP016594.1|WP_033203879.1|3343334_3344375_+|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl|CDD|240633
NZ_CP016594.1|WP_004019879.1|3329299_3330124_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_033204003.1|3337326_3338313_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|236898
NZ_CP016594.1|WP_141638818.1|3324978_3325407_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004019876.1|3331280_3332042_+|pirin-family-protein	unknown	unknown	gnl|CDD|380375
NZ_CP016594.1|WP_004019866.1|3341391_3342963_-|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|173856
NZ_CP016594.1|WP_004019875.1|3332200_3332980_+|aquaporin-Z	unknown	unknown	gnl|CDD|235453
NZ_CP016594.1|WP_004019882.1|3325733_3326522_+|IclR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224332
NZ_CP016594.1|WP_004019871.1|3336575_3337295_-|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl|CDD|376667
NZ_CP016594.1|WP_004019874.1|3332990_3333962_-|DUF1214-domain-containing-protein	unknown	unknown	gnl|CDD|227659
NZ_CP016594.1|WP_004019869.1|3338401_3339421_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|223521
NZ_CP016594.1|WP_004019872.1|3335197_3336556_-|glucarate-dehydratase	unknown	unknown	gnl|CDD|211799
NZ_CP016594.1|WP_004019873.1|3334185_3335193_-|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl|CDD|240642
NZ_CP016594.1|WP_004019877.1|3330523_3331198_+|DUF1345-domain-containing-protein	unknown	unknown	gnl|CDD|377769
NZ_CP016594.1|WP_004019868.1|3339417_3340416_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224094
NZ_CP016594.1|WP_004019862.1|3344374_3344770_+|universal-stress-protein	unknown	unknown	gnl|CDD|238182
NZ_CP016594.1|WP_004019878.1|3330120_3330414_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004019867.1|3340447_3341374_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|223674

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016594.1|WP_004019880.1|3327297_3329241_-|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit	gnl|CDD|236101	PRK07803, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
NZ_CP016594.1|WP_004019881.1|3326546_3327296_-|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	gnl|CDD|237086	PRK12386, PRK12386, fumarate reductase iron-sulfur subunit; Provisional.	0
NZ_CP016594.1|WP_033203879.1|3343334_3344375_+|2-hydroxyacid-dehydrogenase	gnl|CDD|240633	cd12156, HPPR, Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase. Hydroxy(phenyl)pyruvate reductase (HPPR) catalyzes the NADP-dependent reduction of hydroxyphenylpyruvates, hydroxypyruvate, or pyruvate to its respective lactate. HPPR acts as a dimer and is related to D-isomer-specific 2-hydroxyacid dehydrogenases, a superfamily that includes groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	1.76356e-158
NZ_CP016594.1|WP_004019868.1|3339417_3340416_-|ABC-transporter-permease	gnl|CDD|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.65075e-83
NZ_CP016594.1|WP_033204003.1|3337326_3338313_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|236898	PRK11308, dppF, dipeptide transporter ATP-binding subunit; Provisional.	2.86781e-139
NZ_CP016594.1|WP_004019866.1|3341391_3342963_-|peptide-ABC-transporter-substrate-binding-protein	gnl|CDD|173856	cd08491, PBP2_NikA_DppA_OppA_like_12, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP016594.1|WP_004019876.1|3331280_3332042_+|pirin-family-protein	gnl|CDD|380375	cd02910, cupin_Yhhw_N, Escherichia coli YhhW and YhaK and related proteins, pirin-like bicupin, N-terminal cupin domain. This family includes the N-terminal cupin domains of YhhW and YhaK, Escherichia coli pirin-like proteins with unknown function. YhhW is structurally similar not only to human pirin but also to quercitin 2,3-dioxygenase (quercitinase). Although the function of YhhW is not completely understood, YhhW and its human ortholog have quercitinase activity and are likely to play an important role in transcription and apoptosis. This N-terminal cupin domain of YhhW has a metal coordination site and is thought to have catalytic activity while the C-terminal cupin-like domain has diverged considerably and has closer alignment with C-terminal pirin. YhaK is found in low abundance in the cytosol of E. coli and is strongly up-regulated by nitroso-glutathione (GSNO). There are major structural differences at the N-terminus of YhaK compared with YhhW; YhaK lacks the canonical cupin metal-binding residues of pirins and may be involved in chloride binding and/or sensing of oxidative stress in enterobacteria. YhaK showed no quercetinase and peroxidase activity; however, reduced YhaK was very sensitive to reactive oxygen species (ROS). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	1.1472e-47
NZ_CP016594.1|WP_004019875.1|3332200_3332980_+|aquaporin-Z	gnl|CDD|235453	PRK05420, PRK05420, aquaporin Z; Provisional.	1.53575e-114
NZ_CP016594.1|WP_004019882.1|3325733_3326522_+|IclR-family-transcriptional-regulator	gnl|CDD|224332	COG1414, IclR, Transcriptional regulator [Transcription].	8.51361e-58
NZ_CP016594.1|WP_004019871.1|3336575_3337295_-|sulfite-exporter-TauE/SafE-family-protein	gnl|CDD|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	8.94071e-07
NZ_CP016594.1|WP_004019874.1|3332990_3333962_-|DUF1214-domain-containing-protein	gnl|CDD|227659	COG5361, COG5361, Uncharacterized conserved protein [Function unknown].	8.39445e-25
NZ_CP016594.1|WP_004019869.1|3338401_3339421_-|ABC-transporter-ATP-binding-protein	gnl|CDD|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.0551e-158
NZ_CP016594.1|WP_004019872.1|3335197_3336556_-|glucarate-dehydratase	gnl|CDD|211799	TIGR03247, glucar-dehydr, glucarate dehydratase. Glucarate dehydratase converts D-glucarate (and L-idarate, a stereoisomer) to 5-dehydro-4-deoxyglucarate which is subsequently acted on by GarL, tartronate semialdehyde reductase and glycerate kinase (GenProp0716). The E. coli enzyme has been well-characterized.	0
NZ_CP016594.1|WP_004019873.1|3334185_3335193_-|2-hydroxyacid-dehydrogenase	gnl|CDD|240642	cd12165, 2-Hacid_dh_6, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	7.48794e-105
NZ_CP016594.1|WP_004019877.1|3330523_3331198_+|DUF1345-domain-containing-protein	gnl|CDD|377769	pfam07077, DUF1345, Protein of unknown function (DUF1345). This family consists of several hypothetical bacterial proteins of around 230 residues in length. The function of this family is unknown.	9.2352e-05
NZ_CP016594.1|WP_004019862.1|3344374_3344770_+|universal-stress-protein	gnl|CDD|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	1.32489e-10
NZ_CP016594.1|WP_004019867.1|3340447_3341374_-|ABC-transporter-permease	gnl|CDD|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.34331e-97

Protein sequences

>NZ_CP016594.1|WP_004019874.1|3332990_3333962_-|DUF1214-domain-containing-protein
MPVQQEPVRVNADNFVRAETHRMFADIQRAAGGVGVFRHNREPASIEEQTVIRLNRDTLYSFAVVDLARPAVLTLPDAQGRYVSAMIVNEDHYVGGVLHAEGRHELTAERFGSRYVLVAVRILVDPVDPDDVAKVVTLQDQVSVEPGSSEPFVSPDYDTATLDDTRAALLALARGLESFDRTFGTRGDVDPVRHLIGCAAGWGGLPTSEATYIGVDPEREPGLYELTFDEVPVDAFWSVSVYNAAGFFEPNARNLYTVNSVTGERNEDGSVTVRFVPTADGELPANAIVTPRGWNYLIRLYRPRPEILDGTWTPPELMERSDA
>NZ_CP016594.1|WP_004019875.1|3332200_3332980_+|aquaporin-Z
MPSPSPAARLAAEFFGTFWLVFGGCGSAIYAAKQIAQSDDGQDTFQVGIGFLGVSLAFGLTVVTMAYAVGHVSGAHFNPAITLGAAISGRMSWKELPTYWIAQVVGGLLAGLMLFLIAKGRPGFVAEGNMAANGYGEHSPGNYSLTAVLIAEVLLTAFFLIVVLGATDGRAPAGFGPLAIGLCLTLIHLISIPISNTSVNPARSTAVAFFNGNGAPGQLWAFWLAPLIGGLIGGLLYPLLFQNGKRAAPEPARTETADA
>NZ_CP016594.1|WP_004019876.1|3331280_3332042_+|pirin-family-protein
MSEARAAAVTTRQVIRAAGRHGFRSEWLDSRQSFPVTGNFDLTANAHGVLLVHNDDRVDAGEGFDAHFHRDAEIITWVLEGAVAHRDSFGNTGVITPGVAQRMSAGRGITHTEANASRRSEDRDLRVIQMWVAPEHAGGEPGYAERDFTTDLAAGGLVTVASGMPEHTDTTAISIKNPHAALHVARLGSGQSVILPPAPFGHLYVARGGVELDDGIQLAEGDALRTTDHGDVTVSATMDTEILFWEMHSTFRR
>NZ_CP016594.1|WP_004019877.1|3330523_3331198_+|DUF1345-domain-containing-protein
MNDDDHRPGENLPRAEQRWTASAFVLVAMAIPFLLPARYAAGTAWLLPAIEGMVLLTLVVVDPGRIDRPGRWVRALSVCLVVAIAAGAAWGAGRLVWDLLHGNPQTEAANQLLVAGALVWLQTVIAFAFLYWELDGGGPVNRHLHPAEHPDLAFPQQLEPRLAASGWRPVFFDYLYLALTNATAFSPTDVMPLARRAKLAMASQSLLSIVILSLVVANAVNLLD
>NZ_CP016594.1|WP_004019878.1|3330120_3330414_-|hypothetical-protein
MIPTEIRDLHRSIGALRHHMTTLQTQYGDVDAVRRMSNDLDRLEIDLHDFEHAPPPLLQAKLGRDQVIYVPDSKSDESAWLGAQDEGLGFHSRERTK
>NZ_CP016594.1|WP_004019879.1|3329299_3330124_-|hypothetical-protein
MSAPATERDAVGVFSPGRARILARTLRQDRWWLSPLLTVIGLAAFVIYATVRSFVRTAYYSTEYHYLSPFYSPCLSESCVPGASHFGTPFPELPMWIPLAFLSLPFLLGFRLTCYYYRKAYYRSVWLSPPACAVAEPHSRYTGETRLPLIIQNSHRYFFYAAVIISVINTYDAVIAFHGADGGFGFGLGNVILVVNVLLLWTYTVSCHSCRHVTGGRLKHFSKHPVRYWIWTRVSKLNTRHMQFAWITLGTLVLTDFYIMLVASNTISDLRFVG
>NZ_CP016594.1|WP_004019880.1|3327297_3329241_-|fumarate-reductase/succinate-dehydrogenase-flavoprotein-subunit
MTEPERYEYDVVVIGAGGAGLRAVIEARERGYSVAVVCKSLFGKAHTVMAEGGCAASMGNANSKDNWQTHFQDTMRGGKFLNNWRMAELHAKEAPDRVWELETYGALFDRTEDGRISQRNFGGHTYPRLAHVGDRTGLELIRTMQQKIVSLQQEDFAATGDYESRIKVFAECTITDLLKDGDAIAGAFGYWRESGRFILFEAPAVVVATGGIGKSFKVTSNSWEYTGDGHALALRAGASLINMEFVQFHPTGMVWPPSVKGILVTEGVRGDGGVLKNTDGKRFMFDYIPPVFKGQYAETEEEADEWLADNDSARRTPDLLPRDEVARAINEEVKAGRGTEHGGVYLDIASRMPAEEIMRRLPSMHHQFKELADVDITAEPMEVGPTCHYVMGGIEVDPDTAASRVPGLFAAGECSGGMHGSNRLGGNSLSDLLVFGRRAGLGAAAYVESLTTRPTVSAADIERAATSALAPFDPPAEGKPENPYTLHTDLQQAMNDLVGIIRKEAEMQEALDVLADLRNRLGGMQVEGHRQFNPGWHLAIDLRNMLLVCECVAKAALMRTESRGGHTRDDHPSMDSNWRNALLVCTAELDGDGPVPEVSVVRTEQTPMRPDLLELFEFPEIEKYYTAAEIAGHPGAGGERAEGHSED
>NZ_CP016594.1|WP_004019881.1|3326546_3327296_-|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit
MGYDAKFRIWRGDTDAGGLEDYTVVVNEGEVVLDIIHRLQATQAPDLAVRWNCKAGKCGSCSAEVNGRPKLLCMTRMSTFTEDEVVTVTPMRTFPVIRDLVTDVSFNYAKAREIQSFTPPEGLGPGEYRMKQVDVQRSQEFRKCIECFLCQDTCHVVRDHEENKQNFAGPRFLMRVAELDMHPLDVAERRDTARTEHGLGLCNITKCCTDVCPEQIKITDNALIPMKERVADRHYDPLVWLGNKLFRRH
>NZ_CP016594.1|WP_004019882.1|3325733_3326522_+|IclR-family-transcriptional-regulator
MTPARSIELDPKNHIASIVKAIDVLEAFKGDRAELSLAELMTKCGHSRTTMYRILNTLEVAGWVERTRSADYRLTLRVFELASAVLGSFDLRTEASHVMSELAARFDEHVYLLVPDGARAVCLDMIESSQPIRVMVLSVGRSLPLYLGGAPVALLAELEETALPQVLESRPMLTPAGDEITEEELRATLAETRRRGYSISVGDVTPGVAALGACIRDRKGNVVAALSIGGLSADLSDERQDEMAAALVDGALTVSRRLGYAG
>NZ_CP016594.1|WP_141638818.1|3324978_3325407_-|hypothetical-protein
MPGWDVLRTFVDRFAPDVSVDLSTRFAATIAEWEANPTRVTYGVVGGRDVLVGLSYQTSPEEVLAAVWRGLCVSLARTLRDNGVDGPVRLESGHPGADVLADRLSRLGVRVQGVRTPVDAEDRVRIDALVRAVADTAREVSR
>NZ_CP016594.1|WP_004019873.1|3334185_3335193_-|2-hydroxyacid-dehydrogenase
MAESHSGGGGLKVVVGERNFAPHRDLFESLLPVGVDTSWHAAFDEAALVTDLADADVYIGGRVTPSMARAGSRLRLVLTGGAGTDKVSFDDLPAHTLVANTFHHEDSIAEYIAAAAVTVRRDLLVQDAALRQGVWASAVYRDGVPQPQTLRGAMVGYVGFGHIGRRTADLLGAFGARACAVTGSGRVADDSGLEWHGDTTDLGRLMTESDVVVVSAPLTSSTTGMIDAAHLRRLGPSGVLVNVGRGPLVVEQDLFEALQDGVIGGAAVDVWYRYPTAGDEAAPSDLPFAELPNVLMTPHISGVTRDTFVGRVHDITDNISRLLAGRDILRVVTPS
>NZ_CP016594.1|WP_004019872.1|3335197_3336556_-|glucarate-dehydratase
MTTATPTPAATTTPVVTEMRVIPVAGRDSMLLNLSGAHAPFFTRNLVVLTDSEGNQGVGEVPGGEPIRTTLDDARPIVEGRGIGEYNAVLQDIRRTFADRDRGGRGDQTFDQRITIHAVTAVESALLDLLGQHLRVPVAALLGEGQQRDRVAALGYLFFVGDRTKTTLDYADGADETDEWMRLRHQEALDADGVVALAEAAQKRYGFADFKLKGGVLSPEEEADVVTALAERFPAARVTLDPNGGWLLEEAIRIGGRLRDVVAYAEDPVGPEGRFSGREVMAEFKRATGLPTATNMIATDWRELGHTIRTNAVDIPLADPHFWTMAGSVRVAQLCDAWGLTWGSHSNNHFDVSLAMFTHVAAAAPGEITAIDTHWIWQDGQRLTTEPYEIVDGHLTVPDRPGLGVELDMEQVDAAHHLYLTEGLGARDDSIGMQFLIPDWTFDSKRPALVRS
>NZ_CP016594.1|WP_004019871.1|3336575_3337295_-|sulfite-exporter-TauE/SafE-family-protein
MSVVACVIIAVAVFLASCMQASIGFGMGMLAAPVVALVAPTLLPGMLIASATTVTLLVVIRERGSLDLRGTGWALIGRVPGTIAGALLLVWLPTRGLSLLLAAVVLGGVAVASVGWRPAPGRRNLATAGAASGLLGTATSIGGPPMALVYSGKESAHVRSNMSAFFLAGSLMSLAALAATGSLRAEILWAFVALTPVVVLGFVASRLVNRLLDRNRLRMVSITVSGIGAVLLIGQQLFF
>NZ_CP016594.1|WP_033204003.1|3337326_3338313_-|ATP-binding-cassette-domain-containing-protein
MRDVGKTFAVSGKGGRKQLRALDGIDLELRRGETLGLVGESGCGKSTLARTLMMLERPDTGTVRWDGTDPYRLKGKDLLALRRKVQMVFQDPYASLNNRMTAAEIIGEPWRTHRDLYPRKRDRAARVRELLHLVGLRPSDEHRSPQEFSGGQRQRLGIARALALDPEVIICDEPVSALDLSVQAQVLNLLNELQQELDISYIFISHDLSVVRHVADRVAVMYLGRIVETGSTEAVFDHPAHPYTEALMSAAPTLDAENRRERILLSGEVPSPLNPPSGCRFRTRCAHATDLCATALPPAVTDHGEIGHVAECYHPRGRVGLGMPAPAA
>NZ_CP016594.1|WP_004019869.1|3338401_3339421_-|ABC-transporter-ATP-binding-protein
MSAPALDRPDAGTDDRVALDVVDLTVDLRTPTGTVRAVDHVSFRARRGETLALLGESGCGKSMTAQALVGLLDPIASVSDGSITLDSVDLVSASPSKRRDVAGTELAIVFQDALTALNPVYPVGTQLAEPFRIHRRMSKKKARLEAIELMRHVGIPEPESRVDSYPHQFSGGMRQRLLIAMAVALSPKVLLADEPTTALDVTVQAQIMALLGRLRAEHDMAVVLITHDLALVAEQADRVAIMYAGNVVETGPVAEVFGSPKHPYTKGLLDSVPVSAERGADLKSIGGTPPDLHSIPTGCVYQARCPLARAQCVQERPTLTATGTNRAAACHFSEEIDNV
>NZ_CP016594.1|WP_004019868.1|3339417_3340416_-|ABC-transporter-permease
MSIVTDPVDSTSPVASTDITGDSVATKKVPAGQLPLWRLLFRDKFATVAAGILTLVLLTAVFGPWLVGDAATDQNLDESNLPPFNLDTGWMNILGTDPLGRSMLARLIVACQTTLMVSLPAVIISCVVGSAIGMWAGYHRGWRETTAMRIADVIMSFPSLLLAVVILYVFSPSAANIIAVLAITRIPIYLRTARAESAELQSRVFVDAARTFGASSGAILRGHVLPILLPTLLTVATLDFCYVMLAESSLSFLGIGIQPPDISWGLMVSQGRTYLQTAWWLSFFPGLAIVITTVSATMLAAWARIATDPGQRWRLTTPNARKRFFSSRKALR
>NZ_CP016594.1|WP_004019867.1|3340447_3341374_-|ABC-transporter-permease
MLTFLRRRMFTSLIPLIIVLFGVFFMARLTGDPTNLYLPVSATPDQRAEFAAANGLDKPVWQQMTDYLAGVVHLDFGESLKTGQEAAGMALRAFPATLQLAFVTLVLSILGSIIIGCWAAYRPNSLADRFSSLLSMTAASVPDFWFAITGIWIFAVVAGWLPTSGTGGMLAWVLPIATLMIRPLGVLTQVVRGAMVSALSAPYVKVARSKGAGDLRIVTHHALRNAAAPALTVAGDLAVGLINGAVIVEAIFGWPGIGKLMIDSILQRDFAVLQAAVLLTAISIFILNIVIDAGLALLDPRVRDKATV
>NZ_CP016594.1|WP_004019866.1|3341391_3342963_-|peptide-ABC-transporter-substrate-binding-protein
MQIAVLRSRKRPAGLLALSAVAVLAATGCSVANTTAGESASPDTLRIVLPQEPPTLEPCDASLTATGVVVRSNITEPLIERDPNSGALEPSLATEWTQVEPNVWRFTTASGIRFSNGQPFDAEDAAFSIRRTFNGAIGCDVNGYVFDDSTREVTVVDPNTVEVRTATPDPILPLRLSFIEIVPRTTVADDKVRVPIGTGPYMVDFWDSGQRVALKANPNYHGEAPEFTRAVYQWRSEGSVRAAMVTNDEADVATSLGPEDGAGDLGIAYTNNETTALRMQATDAPLNDYRVREAIDHSINRDGIVDALFQGLGIPAAQLVGKGIVGYNDRLTPTPYDLDRARELVDEARADGVPVDRTIRLIGRTGQFPKINETIENLQFTLSEIGLDVKIEMMDTSGQMQYQTRPFVPGSGPVLLMIMHGNQAGDTQFTLDQYMLSDGYQSTYGTPAYDEQIRAAEALTGAARQNALADVLAAEPREIRQYAYIAHMQAVLAKSSRVAYQPNSATGDEMRLAEMTHAPAQND
>NZ_CP016594.1|WP_033203879.1|3343334_3344375_+|2-hydroxyacid-dehydrogenase
MTSSSAGTTTASETVATNGFSPMHGTILRVGPLKPSLEERLAETYGAERLPDDDEERTSFLARNADAVTAVVTSGRTGVDAGLMAALPNLGAIVHFGVGYDTTDVDRATELGIGVSNTPDVLTDCVADTAVGLLLDTMRGLSAADRFVRAGRWPDEGNVPLTRKVSGTDVGILGLGRIGSAIAHRLDAFGCRIAYHNRHRVADSPYRYAASPAELAAQVDVLIVAAAGGANTRHLVDRHVLEALRPDGFLINVARGSVVDETALVDLLQHGRLAGAGLDVFAHEPEVPEALLSMDNVVLLPHLASGTVETRAAMEELTLANLDSFLRTGDLSTPVVAPNPALRKDI
>NZ_CP016594.1|WP_004019862.1|3344374_3344770_+|universal-stress-protein
MSVVLSYLPTPEGRGALPFGFAEARMRGTDVVVVADGDNASSPEFLVDLENARDLAQAGEVDYRVAENDPGLSHADQLIDASYDDAAELLVIGQRRRSPVGKLLTGSVVQRVLLDAQCPVVAVKPPVRAAV

Crispr_ID: NZ_CP016594_8

• CRISPR_ID: NZ_CP016594_8
• CRISPR_location: 3878991-3879090
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of NZ_CP016594_8

Consensus_repeat	Method
CGACGGGCGCCGGGAGCGGAGCGA	CRISPRCasFinder

spacers of NZ_CP016594_8

>8.1|3879015|52|NZ_CP016594|CRISPRCasFinder
GCGGGCCCAGGTGTCGACGGGCGCCGGGAGCGGAGCGAGCGGGCCCAGGTGT

CRISPR arrays and Neighbor proteins around NZ_CP016594_8

CRISPR arrays

The CRISPR arrays of NZ_CP016594_8

>merge|NZ_CP016594|8|3878991-3879090|CRISPRCasFinder
CGACGGGCGCCGGGAGCGGAGCGAGCGGGCCCAGGTGTCGACGGGCGCCGGGAGCGGAGCGAGCGGGCCCAGGTGTCGACGGGCGCCGGGAGCGGAGCGA

>NZ_CP016594|8|8|3878991-3879090|CRISPRCasFinder
CGACGGGCGCCGGGAGCGGAGCGA	GCGGGCCCAGGTGTCGACGGGCGCCGGGAGCGGAGCGAGCGGGCCCAGGTGT
CGACGGGCGCCGGGAGCGGAGCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016594.1|WP_004022578.1|3883825_3885061_-|serine-hydrolase	unknown	unknown	gnl|CDD|365903
NZ_CP016594.1|WP_004022565.1|3870995_3871919_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|181139
NZ_CP016594.1|WP_004022566.1|3872007_3873030_-|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl|CDD|376559
NZ_CP016594.1|WP_004022572.1|3877681_3878974_-|transporter	unknown	unknown	gnl|CDD|366411
NZ_CP016594.1|WP_004022569.1|3875159_3876056_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004022581.1|3886545_3886917_-|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
NZ_CP016594.1|WP_004022576.1|3882191_3883043_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|223673
NZ_CP016594.1|WP_004022564.1|3870201_3870999_-|phosphotransferase	unknown	unknown	gnl|CDD|225547
NZ_CP016594.1|WP_004022570.1|3876246_3876591_+|Lsr2-family-protein	unknown	unknown	gnl|CDD|378714
NZ_CP016594.1|WP_033205737.1|3869596_3870166_-|nucleosidase	unknown	unknown	gnl|CDD|235538
NZ_CP016594.1|WP_004022575.1|3881362_3882151_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224041
NZ_CP016594.1|WP_004022582.1|3887086_3888457_+|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274819
NZ_CP016594.1|WP_004022580.1|3886056_3886542_-|SRPBCC-domain-containing-protein	unknown	unknown	gnl|CDD|176856
NZ_CP016594.1|WP_004022571.1|3876681_3877728_+|PHP-domain-containing-protein	unknown	unknown	gnl|CDD|236135
NZ_CP016594.1|WP_004022579.1|3885159_3886053_+|4,5-DOPA-dioxygenase-extradiol	unknown	unknown	gnl|CDD|153375
NZ_CP016594.1|WP_004022577.1|3883158_3883758_-|DUF1707-domain-containing-protein	unknown	unknown	gnl|CDD|377959
NZ_CP016594.1|WP_004022568.1|3874297_3875158_-|rhodanese-related-sulfurtransferase	unknown	unknown	gnl|CDD|234663
NZ_CP016594.1|WP_004022573.1|3879129_3880224_-|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274652
NZ_CP016594.1|WP_004022574.1|3880256_3881330_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270276
NZ_CP016594.1|WP_004022567.1|3873242_3874301_-|GTP-binding-protein	unknown	unknown	gnl|CDD|223597

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP016594.1|WP_004022581.1|3886545_3886917_-|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	1.4e-14	49.2	0.6

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016594.1|WP_004022565.1|3870995_3871919_-|SDR-family-oxidoreductase	gnl|CDD|181139	PRK07832, PRK07832, SDR family oxidoreductase.	9.80455e-166
NZ_CP016594.1|WP_004022566.1|3872007_3873030_-|N-acetylmuramoyl-L-alanine-amidase	gnl|CDD|376559	pfam01520, Amidase_3, N-acetylmuramoyl-L-alanine amidase. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls.	3.56934e-38
NZ_CP016594.1|WP_004022572.1|3877681_3878974_-|transporter	gnl|CDD|366411	pfam00999, Na_H_Exchanger, Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.	3.71772e-23
NZ_CP016594.1|WP_004022564.1|3870201_3870999_-|phosphotransferase	gnl|CDD|225547	COG3001, COG3001, Uncharacterized protein conserved in bacteria [Function unknown].	1.60795e-50
NZ_CP016594.1|WP_004022581.1|3886545_3886917_-|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	4.06596e-12
NZ_CP016594.1|WP_004022576.1|3882191_3883043_-|ABC-transporter-permease	gnl|CDD|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	1.41927e-74
NZ_CP016594.1|WP_004022578.1|3883825_3885061_-|serine-hydrolase	gnl|CDD|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	5.05502e-46
NZ_CP016594.1|WP_004022570.1|3876246_3876591_+|Lsr2-family-protein	gnl|CDD|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	3.19309e-45
NZ_CP016594.1|WP_033205737.1|3869596_3870166_-|nucleosidase	gnl|CDD|235538	PRK05634, PRK05634, nucleosidase; Provisional.	3.09009e-78
NZ_CP016594.1|WP_004022575.1|3881362_3882151_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	5.42562e-99
NZ_CP016594.1|WP_004022582.1|3887086_3888457_+|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP016594.1|WP_004022580.1|3886056_3886542_-|SRPBCC-domain-containing-protein	gnl|CDD|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	1.58265e-29
NZ_CP016594.1|WP_004022571.1|3876681_3877728_+|PHP-domain-containing-protein	gnl|CDD|236135	PRK07945, PRK07945, PHP domain-containing protein.	4.85083e-171
NZ_CP016594.1|WP_004022579.1|3885159_3886053_+|4,5-DOPA-dioxygenase-extradiol	gnl|CDD|153375	cd07363, 45_DOPA_Dioxygenase, The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine. This subfamily is composed of plant 4,5-DOPA Dioxygenase, the uncharacterized Escherichia coli protein Jw3007, and similar proteins. 4,5-DOPA Dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA Dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain. Homologs of DODA are present not only in betalain-producing plants but also in bacteria and archaea. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon.	2.20723e-113
NZ_CP016594.1|WP_004022577.1|3883158_3883758_-|DUF1707-domain-containing-protein	gnl|CDD|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	7.31771e-18
NZ_CP016594.1|WP_004022568.1|3874297_3875158_-|rhodanese-related-sulfurtransferase	gnl|CDD|234663	PRK00142, PRK00142, rhodanese-related sulfurtransferase.	1.78848e-141
NZ_CP016594.1|WP_004022573.1|3879129_3880224_-|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274652	TIGR03565, alk_sulf_monoox, alkanesulfonate monooxygenase, FMNH(2)-dependent. Members of this protein family are monooxygenases that catalyze desulfonation of aliphatic sulfonates such as methane sulfonate. This enzyme uses reduced FMN, although various others members of the same luciferase-like monooxygenase family (pfam00296) are F420-dependent enzymes. [Central intermediary metabolism, Sulfur metabolism].	4.0229e-154
NZ_CP016594.1|WP_004022574.1|3880256_3881330_-|ABC-transporter-substrate-binding-protein	gnl|CDD|270276	cd13558, PBP2_SsuA_like_2, Putative substrate binding domain of sulfonate binding protein, the type 2 periplasmic binding protein fold. This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.14158e-97
NZ_CP016594.1|WP_004022567.1|3873242_3874301_-|GTP-binding-protein	gnl|CDD|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	2.55293e-70

Protein sequences

>NZ_CP016594.1|WP_004022572.1|3877681_3878974_-|transporter
MTPAETLLVDTASSGPVLVLAESGDSATSVTVSLFWIALVAVISPLLSRMSRGYVPDAVLLLGSGILIGPHALDVASQDGIDVLSQLGLGMLFLLAGYELDPKLLGGRTGRIAQLSWLVSLLIALAAVTLVAVTLALGLGETGFTAHVAVAIALSSTALGTLLPILKQAGLERTRLGRAVMAHGAVGELGPVVAMSLLLTSRSIGAAVVVLLLFAIAALLISAAPQRILARVPGIGAAIREAAGGTVQLPVRVVVLLLVSLMTVASVFDLDVVLGAFAAGLILRRLIGPEHPQVGTSLEVIGFGILIPIFFVTSGMNIDVSAVASEPGLWVVLILAIAIARGGPVWAGAGRLDDGYFLRRPRERTQLAFFAATGLPIIVAVTQVAVSSELMSDELASILVAAGATTVLLFPLIARLIGRATPTAAPTTTS
>NZ_CP016594.1|WP_004022571.1|3876681_3877728_+|PHP-domain-containing-protein
MRSFTPLSAPVDPVGALERISWLLERRRESTYRVEAFRRAGQAAAGLDPSEMQARAAAGTLTAIKGIGKTTAAVISEAAAGELPGYLARLQSEDPPTAPDDAAGLVEAVVGDLHAHTDWSDGGAPIDEMAAAAEASGHDWLAITDHSPRLTIANGLSAERLASQIEAIDAWNSAHATSFRLFRGIEIDILDDGALDQTDEMISRLDVVTASVHSNLRMAHAAMTSRLVAAVSDPRVHVLGHCTGRRVLSGRGHRPPSTFDAEAVFAACAANDTVVEINSRPERVDPPDELIEIARDAGCLFAIDSDAHAPGQLDFKILGARRAAAHGIDPDRIVTTWSSERLSEWLAR
>NZ_CP016594.1|WP_004022570.1|3876246_3876591_+|Lsr2-family-protein
MAKKEIVQVIDDLDGKVLDQYETVRWSLDGKNYEFDTSSKHAQQFRDSLSKYLDISRQTGRVTKRATTASAATGGGRNKETTKAIREWAIKEGYELSDRGRIPQSIIEAFEAAH
>NZ_CP016594.1|WP_004022569.1|3875159_3876056_+|hypothetical-protein
MQGYGNRRPRPESTSGSRDHRFLRVICATAAIGTLSVSAALAGCSLPSESGPSRIVIPPTDELSTVTETESSSTTSTTGEDSAQNLPEWTIGRVIAMAPRVDNSRFHQGSVTEDSPLQDSSGFHFSTPDRAVNCSTGTNGTSTLACRIDDEQGDDSPARPPSSVPAACDWERDLAILGPDGPQRGACANRYPVLYRSSIVDFGRTISISRFSCLVETAGMFCLESRSKSGFAITPNGYQTIYAADRAPESLVSVSPEESDESSRRTAGADSTTVTTPTSNRTATPRNPGPTTSTEPTR
>NZ_CP016594.1|WP_004022568.1|3874297_3875158_-|rhodanese-related-sulfurtransferase
MPTPKIVLFYVFVPLPDPEAIRLWQLAVCESLGVRGRIIVSRHGINSTVGGDIAAVKRYVRTTRAYPGFAGADIKWSDGTGRDFPKLSVRVRPEIVTFGVPDEIEVDENGVVDTGTRLTPEQVHELVDARGDDVVFFDGRNEIEAQVGRFAGAVTTKARTTRDFVPLIESGAFDHLKDRPIVTYCTGGVRCEVLSTVMRHRGFSEVYQLDGGIVRYGERYGDDGLWQGSLYVFDDRMGVQFSDRAQVLGRCVDCGRPTSNVANHPDRDGRDLAVICPDCLGPEAHR
>NZ_CP016594.1|WP_004022567.1|3873242_3874301_-|GTP-binding-protein
MSTVRTSDRRGPVPVVVVAGYLGSGKTTLLNHLLRSAGATGTRLGVLVNDFGKVNIDALLVSAQADGTVSLGNGCMCCTVDADGLADALTSLVRPSVGIDAIVIEASGIAEPKALIRMVTSVADARLRYGGLVYVVDAAHIEAVRRTHPELDAHVSIADLVLVNKVDLISDDTRHAVEELVAQLNATAPRVATRNAAIDPELLFDLARREVEQAGPGQLTLDELLLEEGGHDHHEHLHAAYESVSFSSDRPMDPRRLARFLERPPDGCFRIKGIVHFDVPRHRQRFVVHGVGGFVRVLREPWGDRRPVTELVTIGRGLDVAAVRAELDAALARPADAADENGILGVLRHLAD
>NZ_CP016594.1|WP_004022566.1|3872007_3873030_-|N-acetylmuramoyl-L-alanine-amidase
MFRKTTTRRLTSIAFAVVAATSTVVASNLFAPTADAAPARGTALAGKTVFLDPGHQASAAGHDLKAQVPDGRGGKKDCQTSGATGVNGAREHTVNWQIGQLVKAGLESQGARVVLSRPDDTGWGGCVDERAAAASRSGAAVAVSLHADSTARGADESKKGFHMIVPSLPVPDATVDRVQSGEGRKASTTMRDAFVKAGFPSANYAGVRDGIQTRSDIAAVNLTKVPAVFIEMGNLANPGEAKALAGRDGQVKYAMAITDGILNYVNGNAATGAGPAPSTPTDDASGLSSIIPFVEQLLATEDPEAVARLLMTQGQDVSAQVLKAMLTIVYGLFDGKLPIG
>NZ_CP016594.1|WP_004022565.1|3870995_3871919_-|SDR-family-oxidoreductase
MGIKELLFMDTPVPSLRGRKVLITGAASGIGRATAQAAAARGAELVLTDLHADQLDEVVAGITAADGTVLYHVAGDVSDFDWVAGFARQVDAEVGVMDVVMNIAGISAWGTVENLEHRHWRTLVDVNLMGPIHIIESFVPQMIRRGRGGHIVNVSSAAGLLALPWHAAYSASKFGLRGVSEVLRFDLRRHGIGVSLVCPGGVDTPLVDSVEIVGVDRENPRIKAAINGFHKVAVSPDVAAAAILKGVRKNRFLVYTSFDIRFGYWWARKFALPYEIAMRVANDRFDRLARVSARSLEARAADEHSPR
>NZ_CP016594.1|WP_004022564.1|3870201_3870999_-|phosphotransferase
MSPTFVKTLRDSGPPGGHPDFFAAEAAGLRWLRDAGAPVVQVISLEEHAIELERLEFGRPTPAAARDFGAALARMHDAGAAHFGSPPAGPDGTPFSGQLFIGRRPLSSVEYRSWGEFYAHERVEPYLVPAREAGNLTAADEDAVRDACALIADGVFDDDEGPARIHGDLWNGNVMWTPAGVVMIDPAAHGGHRETDLAMLALFGCPHLNAIVDGYQDVHPLVAGRTDRVAVHQLHPLAVHAAGHGPGYGSSLGRAARAASALARG
>NZ_CP016594.1|WP_033205737.1|3869596_3870166_-|nucleosidase
MPRQGVLVVSATRAEARHVPPGTRVLVTGIGKVRATLSLSRELAGGAPVTEVVNIGTAGALRDGVTGDAELGLFLPSTVLEHDISSTELRAMGYEMTDRWDLPDGDGTVLASGDTFVADPVRRRELAEHAHLVDMEGCAVAHVSAEFGVPCRLVKAVTDNADEGAMEWPALVDAAARRLGRWLELNLVS
>NZ_CP016594.1|WP_004022573.1|3879129_3880224_-|LLM-class-flavin-dependent-oxidoreductase
MSHFHWFLPTAGDSRGIVGASHASATKRHPPGYRAPELPYLIDVARTADRLGYESVLTPTGTWCEDAWLTTAAAITHTEQLKFLVAFRPGLISPTLAAQQTATLQRFSGGRVAVNIVTGGDEVEQRRFGDWVDHDRRYARTDEFLQIVERLWSGETVDFDGEFYQIAGAFLPDPPVVKPQIFFGGSSDPALTVAASRAEVYLTWGEPPAVAGEKIAEVARRASAVGRSLEYGVRLHVIARETSAEAWRVADTLLQGISDEEIATAFALHSGSDSTGQRRMAELHGGRRDALEIHPGLWAGVGLIRGGAGTALVGSYDEVAALIGEYESEGFAHFILSGYPHIEEAHWFAEGVLPVIRDRVGALS
>NZ_CP016594.1|WP_004022574.1|3880256_3881330_-|ABC-transporter-substrate-binding-protein
MTNDPALVRSARPRRRRVFAAVLATAALTMGLAGCVQREDNAESIANETVDVASLQDLTLRVGDQKGGTEALLRASGELEKLPFTVEFSTFTSGPPQIEAATAGKIDFAVTGNTPPIFGAAANAKVKIVTGYANNASGDAILIPGNSPLASVADLKGKKVAVAKGSSAHGHLLLQLNKVNLTLGPGKDVEPVFLQPADALSAFTSGSVDAWAIWDPYTAIVQLENTPKTLVTAEGVSNGFGFGIAGDEALADPRRNTAIRELATGIARAANWAKANPDAWAEQYSAEVGIDPRAGKVAQGRSLRPAIALDDSVVASQQKLADAFADSGQLQGQVDFASFVDNRYDESLAPLFGTPQS
>NZ_CP016594.1|WP_004022575.1|3881362_3882151_-|ABC-transporter-ATP-binding-protein
MTAIATRDLEVPLAEKPAGPVAYAAEVEHASLSYGDNPVLRDVTLRVGAHEIVALIGRSGSGKSTLLRLLAGLSTTEAGTVRTAGHPAVSFQEPRLFPWRTVLQNVAFGLVREKVGKSQARERARHTLDEVGLSDKTGAWPAQLSGGQAQRVSLARALVARPQLLLLDEPFGALDALTRRTMHELLIRLWRDNGFGALLVTHDVDEALRLADRVVVLAGGTIVEDLAVPRPRHTGEPDDPDSEIPRLRAELLTALGVADTTR
>NZ_CP016594.1|WP_004022576.1|3882191_3883043_-|ABC-transporter-permease
MADRTLSISAPGVPRAAKPGSPDDSSASVKAARSSRLHTTLRALSPVAVLVLWQVGSALGIIPQDKLPAPSLIAEAGWEVLGNGQLLDAIAASAQRVAIGLTIGVAVGIGLGLLVGLSKFADSAIDPNMQAIRALPLFGLIPLFILWFGIGEMPKVLLVSLGALFPLYLNTSAAIRQIDGRLVETARVLGFSRLTTVRDLIIPGAMPQILVGLRQALAIAWLSLIVAEQIAATSGLGYLINNARDFLRTDIIFFGLIVYAALGLITDAIVRALERYTTRYQNR
>NZ_CP016594.1|WP_004022577.1|3883158_3883758_-|DUF1707-domain-containing-protein
MVDRLPDDDLRVGNPERERAVTLLNDAFSAGYLEIAEFEDRSGLVYAAKTRADLRAVLANLPNAGRLFNDPSPAAAATPAVAVPSAAPVHLAAEWDTVRRKGTWHVPPSTLVTGSMGTVDLDFTHASFPGPSTTLQFQVSVTTVKLRIGPDHEIRYGDLQLSGWSKVKDKAGAPTRPGGPVIELTGSASGMTGITIKRS
>NZ_CP016594.1|WP_004022578.1|3883825_3885061_-|serine-hydrolase
MRKRWSTLVVVILAVALAACGTDGGSESATSSAASSNPQQAAQIERIVEDLMETKHLKSAIVRVTDDGQDVITKAFGESQTGVPATTDMHFRNGSVAIAYVAAVLLQLADEKTVGLDDIIAKWVPQIPNSDRVTLRQLATMTSGYQDYVLGNDAFETEELTNPFKAWTTEEMLSYAVDKPLLYQPGTNWNYAHTNYVILGLALEKITGESVADLLRQRISEPLDLDNTVSDLTAVIPEPALHAYSSERRGILNLPPTTPFYEETTGWNPSWSITHGAIQTSNIYDVEATARKLFAGETLSSESYDTMVSTSLRGVARPLAGCSTCMTMTDRYTYGMGVVRTGDWVVQNPLFNGYSAVAGYLPSEKIAIAVSVTYDPEAFGPEGSYDNGGNPIFAQIGALMAPDAAPPIPRN
>NZ_CP016594.1|WP_004022579.1|3885159_3886053_+|4,5-DOPA-dioxygenase-extradiol
MTAGHATGPAAVSMPRPMPTAFIGHGNPMNALERNRYTEAWAALGASVPRPRAILVISAHWYTNATAVTAMPRPRTIHDFYGFPQDLFDVEYPAPGDPDVADMVADVVKPTWCGHDVDSWGIDHGTWSVLVHTFPDASIPVLQLSLNAFKDFEHHYDLGRRLAPLREQGVLIIGSGNIVHNLRAVDFAKSDSGFDWANRFDDAAREVLQDNPSDILSLDGHPDFDKSVPTPDHYLPLLYIAGLAGDSPLDLLVNGHAAGSISMAAYTHGLDVEPSGSGADAPAAELPEGFPTLNSNL
>NZ_CP016594.1|WP_004022580.1|3886056_3886542_-|SRPBCC-domain-containing-protein
MPVIDVTPDLDARTITINAEFAAPIDRVWQIYADPRQLEKIWGPPTYPATVVDHDLRPGGRVTYYMTSPEGEKFGGYWKVESVDEPTGFTFLDGFADGDLNPITDMPESRNSYAFTEKDGTTVATYISTYDSAEALQKVLDMGVVEGASSAINQIDEFLAA
>NZ_CP016594.1|WP_004022581.1|3886545_3886917_-|winged-helix-turn-helix-transcriptional-regulator
MTENAGEPTDEDRADALFHALSDRTRRDILRRVLAGEHSVSVLAAKYDMSFAAVQKHVAVLEKAGLLTKRRSGREQLASGDVAAVRSVASMLTELEQVWRGRIARIDDLLSLESPSPTTSSEE
>NZ_CP016594.1|WP_004022582.1|3887086_3888457_+|LLM-class-flavin-dependent-oxidoreductase
MTRQLHLGGFLIASPVTHSHAAWRHPGSVTDYFGPDHYHRVGRILERGKFDFAFFADLLAAPVRFGGDQSEPFRRGTQAAATIDPSLVAASIAAVTTRLGIAVTKSTTYFHPYELARVFGSLDHLTRGRIAWNIVTSLSQAEAQNFGFDDHVGHDERYVRAEEFVRTAIKLWSSWDADAVTADKESGVWADPAKIHTVDHDGAHYRTRGPLNQPRSPQHRPVLIQAGSSNTGKDFAARWAEAIFEIDPTPEGRRAYYDDVKSRAVNFGRNPDHVKIFPSFIPFIGETESIAREKQAFHNELADPISGLITLSVHTDHDFSAYDLDAPVEDVQVSGTQGLFDVARRLSERDSLTLRDIGKLYAQGVLLPQFVGTAADVADQIEESFSGGEADGFIVSSAQTPGTFNDFVDYVVPELQRRGLFRTEYEGTTLREHLGLGTAEEDLPADVRGVDTRLAG

Crispr_ID: NZ_CP016594_9

• CRISPR_ID: NZ_CP016594_9
• CRISPR_location: 3958567-3958692
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP016594_9

Consensus_repeat	Method
GTTTGTGGCGTGGCGCCACAC	PILER-CR

spacers of NZ_CP016594_9

>9.1|3958588|34|NZ_CP016594|PILER-CR
CCTCTGAACTGGGGTTCTGGCGTGGCATGGGGGA
>9.2|3958643|29|NZ_CP016594|PILER-CR
ACTGGGCCGAGGGCCTGGGGCCACACGCC

CRISPR arrays and Neighbor proteins around NZ_CP016594_9

CRISPR arrays

The CRISPR arrays of NZ_CP016594_9

>merge|NZ_CP016594|9|3958567-3958692|PILER-CR
GTTTGTGGCGTGACGCCACACCCTCTGAACTGGGGTTCTGGCGTGGCATGGGGGAAGTTGTGGCGTGGCGCCACACACTGGGCCGAGGGCCTGGGGCCACACGCCGTTTGTGGCGTGGCGCCACAA

>NZ_CP016594|9|1|3958567-3958692|PILER-CR
GTTTGTGGCGTGACGCCACAC	CCTCTGAACTGGGGTTCTGGCGTGGCATGGGGGA
AGTTGTGGCGTGGCGCCACAC	ACTGGGCCGAGGGCCTGGGGCCACACGCC
GTTTGTGGCGTGGCGCCACAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016594.1|WP_004023675.1|3957958_3958441_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_033205684.1|3965086_3965722_+|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl|CDD|378820
NZ_CP016594.1|WP_033205641.1|3963321_3964965_-|alpha-D-glucose-phosphate-specific-phosphoglucomutase	unknown	unknown	gnl|CDD|236050
NZ_CP016594.1|WP_004023677.1|3960157_3960370_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378935
NZ_CP016594.1|WP_004023665.1|3949843_3950590_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|235546
NZ_CP016594.1|WP_141638840.1|3953398_3954025_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004023683.1|3965726_3967511_-|long-chain-acyl-CoA-synthetase	unknown	unknown	gnl|CDD|236217
NZ_CP016594.1|WP_004023676.1|3958694_3959882_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|316042
NZ_CP016594.1|WP_004023680.1|3962486_3963239_-|DsbA-family-protein	unknown	unknown	gnl|CDD|224565
NZ_CP016594.1|WP_004023672.1|3957028_3957310_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004023666.1|3950589_3951768_-|thiolase-family-protein	unknown	unknown	gnl|CDD|238383
NZ_CP016594.1|WP_004023685.1|3968960_3969800_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224054
NZ_CP016594.1|WP_004023664.1|3948716_3949847_-|hypothetical-protein	unknown	unknown	gnl|CDD|238425
NZ_CP016594.1|WP_004023679.1|3960969_3962205_+|site-specific-integrase	unknown	unknown	gnl|CDD|271189
NZ_CP016594.1|WP_004023671.1|3956774_3957032_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_110117434.1|3952246_3952783_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NZ_CP016594.1|WP_004023670.1|3954714_3956613_-|HK97-family-phage-prohead-protease	unknown	unknown	gnl|CDD|273682
NZ_CP016594.1|WP_110117435.1|3960424_3960973_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_141638841.1|3954101_3954647_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_033205687.1|3967707_3968940_+|CoA-transferase	unknown	unknown	gnl|CDD|367110

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016594.1|WP_033205684.1|3965086_3965722_+|prolyl-oligopeptidase-family-serine-peptidase	gnl|CDD|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	9.113e-06
NZ_CP016594.1|WP_033205641.1|3963321_3964965_-|alpha-D-glucose-phosphate-specific-phosphoglucomutase	gnl|CDD|236050	PRK07564, PRK07564, phosphoglucomutase; Validated.	0
NZ_CP016594.1|WP_004023665.1|3949843_3950590_-|SDR-family-oxidoreductase	gnl|CDD|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	1.70166e-86
NZ_CP016594.1|WP_004023677.1|3960157_3960370_-|helix-turn-helix-domain-containing-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	3.37025e-08
NZ_CP016594.1|WP_004023683.1|3965726_3967511_-|long-chain-acyl-CoA-synthetase	gnl|CDD|236217	PRK08279, PRK08279, long-chain-acyl-CoA synthetase; Validated.	0
NZ_CP016594.1|WP_004023676.1|3958694_3959882_-|AAA-family-ATPase	gnl|CDD|316042	pfam13481, AAA_25, AAA domain. This AAA domain is found in a wide variety of presumed DNA repair proteins.	5.97786e-28
NZ_CP016594.1|WP_004023680.1|3962486_3963239_-|DsbA-family-protein	gnl|CDD|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	8.65056e-17
NZ_CP016594.1|WP_004023666.1|3950589_3951768_-|thiolase-family-protein	gnl|CDD|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	3.04069e-175
NZ_CP016594.1|WP_004023664.1|3948716_3949847_-|hypothetical-protein	gnl|CDD|238425	cd00829, SCP-x_thiolase, Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.	1.71219e-28
NZ_CP016594.1|WP_110117434.1|3952246_3952783_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.29317e-10
NZ_CP016594.1|WP_004023679.1|3960969_3962205_+|site-specific-integrase	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.51137e-30
NZ_CP016594.1|WP_004023670.1|3954714_3956613_-|HK97-family-phage-prohead-protease	gnl|CDD|273682	TIGR01543, Putative_prohead_protease, phage prohead protease, HK97 family. This model describes the prohead protease of HK97 and related phage. It is generally encoded next to the gene for the capsid protein that it processes, and in some cases may be fused to it. This family does not show similarity to the prohead protease of phage T4 (see pfam03420). [Mobile and extrachromosomal element functions, Prophage functions, Protein fate, Other].	1.88441e-18
NZ_CP016594.1|WP_004023685.1|3968960_3969800_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.13879e-79
NZ_CP016594.1|WP_033205687.1|3967707_3968940_+|CoA-transferase	gnl|CDD|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.25844e-143

Protein sequences

>NZ_CP016594.1|WP_004023675.1|3957958_3958441_-|hypothetical-protein
MTNTSAGPRGAWVHLFSDTMCGHGCRTVERHGAIVGRTSASVTIQLFDWNVLDNRIPQPLPGEVLVTDAAELASLGAAVYRSYTEARPAELEAVAAGLGQCGHATVRPRRERPYEPVRSERERDTYNAEIGVLSPHELSDAVLDEAERRTPVRVERRTAE
>NZ_CP016594.1|WP_004023672.1|3957028_3957310_-|hypothetical-protein
MTEPTRSDPLGALVTRALLAAGAGDRAQVDRIVTEADRHGHVARLVWQLARALADRLPPDKLIALAVQQADAAAGGPPAGSPGDPRDDERLDR
>NZ_CP016594.1|WP_004023671.1|3956774_3957032_-|hypothetical-protein
MTDDRPTARRVLESARTGRGSKRHRHTEFAAENGARIVVTRYANSAARVTVFSDGSRREFRESSAGDDRWLLAAVGYRLEVTAPV
>NZ_CP016594.1|WP_004023670.1|3954714_3956613_-|HK97-family-phage-prohead-protease
MHVLHKNYELSGLKTAGLADGEFIGWASTYGNIDAQGDRVVKGAFAASVKSITDGDVTPVLWEHKSDDPRMQVGQIKSAEETDEGLRVHVALDLDTETGRAAYKAVKSRRVKSLSIGYGVLQATKATDGAQELKSLDLVEVSLVARPANDRATITASKAADKAGTPALVKARKAAAEFTAADETTDKDDTDETAEMTVGERLVASLESALADAQALIDAAEAEGRDLTEAEADAVEKAHYRARLDKRDLEAWEKSTPSLRHGTQHLADVIHGKSTEAEFTARWGTSDAPAEALTKSVPDSKFIRKTKKHKEIQTMETQDQFLTLGAGRKAFAATIANKMTGADTENAFQGGGMGTKALTTSGQAITDVPIRPDVIPTGRPATSLLDVIPTITRPVPTWRYLRQNARALNAAPVAEGDLKPVSEVGTQTIESGAVVIAHLSEPVGKFILEDAPGLQRFAAEELVFGLDRAVEAQVLAGDGTGENLTGILATSGLQVQTFESSAIVSIRKALTKAEAAGYVPTVAVLRPEAWEEIELTATSADAIAFRGVPIDLTERKIWGLRVVLSTALPVKTGLVLDPAAASIDIVGRRIDIEWSAEAGELFQRNQLQARVEGRFGLSVYQPAAIYRVATAA
>NZ_CP016594.1|WP_141638841.1|3954101_3954647_+|hypothetical-protein
MSAGAPAWVSITALGVAGFAALVALGSAWISFLAYRATGPRILLRTAHISNDPGRQRVIVEFTVVNRGRGEVNVSEFLLTPAGTRKTLLTVGHIEGKQLPFRLVGGAEQSWQANILPVARAYHEGLQRRTYKPKSSWPTHFYFSVRTGDGKIARAREQQFDAPSVIAAVVARTADPVEDDD
>NZ_CP016594.1|WP_141638840.1|3953398_3954025_-|hypothetical-protein
MDEQRNWAEVLAGPLAGASIGAMVVIGLALAGPGRYYGWRLQKVLDLIGGMTSIDGLDDQRRELCADAERLSRRVAAYHRVPTEWHMMIWAALGAVWTYGSIIGLGVWTKDIREGIAGWQTAAFVLSVLVAASPGFLTIHWGLASTRYTYRERLRYVHEGMSGEFHRRLSPRPEWLAPKPDVWNSVDDYRAFADGDPEAGTGDMPNVS
>NZ_CP016594.1|WP_110117434.1|3952246_3952783_+|TetR/AcrR-family-transcriptional-regulator
MIDAALAIFSERPYEAVSTAELATAAGTTRTNLNYHFGSKKNLYIAALRRFTTYPLGLAHSASETSIANEAQIASTFDRWLSFIETHHEPFKVLTQASKSSFCDDEIAGLLDDALSTWEDRLLIMTGQSLTDRAARARVRAFQAMIGAATAQWLEEKVLSKDEVCGLLTRALPTLSSD
>NZ_CP016594.1|WP_004023666.1|3950589_3951768_-|thiolase-family-protein
MKSAVIVDIVRTGAGKGKPGGALSGIHPVNLLAETLRALLERNDLDPATIDDVIAGCVSQAGEQALNIARNAILAAGIPESVPGTTVDRQCGSSQQAVHFAAQGVLAGAYDIVVACGVESMSRVPMGYSSVDQDPNRGPLSARYPEGLIGQGVSAELIAARWKLDREALDEYAARSHQRAAQVTEAGGFQREIVPITVDGHVHDTDQTLRASTTVEGLGGLKPSFVDDGLQQRFPEINWSITPGNSSPLTDAASAVLIMSEKKAGELGLTPRARFTDFAVTGSDPLLMLTGVIPATEKVLTRSGLSIDDIDAYEVNEAFAPVPLAWQQDLKADPEKLNPRGGAIALGHALGASGVRLLATLVNHLEDTGGRYGLQTMCEGGGMANATIIERV
>NZ_CP016594.1|WP_004023665.1|3949843_3950590_-|SDR-family-oxidoreductase
MSIGQITPDFDGTTVLVTGGAQGIGYQIASYFHAAGARVAVLDYDKKLLDEAWGGIDRVHLAAVDVSNGDAVRSAVDDVVAWAGGVDVAVNNAGIARDAVVWKLTDEQWDSVLAVHTTGTFNVTRSVVPHMRAAGAGRIINVTSYTGMHGNIGQSNYAAAKGGIIAFTKSVAKEVARFGVTCNAISPNASTAMVAAVPPDKLAEMTASVPAGRFAEASEMAPAVGFLASAQAAYVTGVVLPVDGGVSM
>NZ_CP016594.1|WP_004023664.1|3948716_3949847_-|hypothetical-protein
MTRLNPSTTAADPIPIIGMAATPLVVESDAVLDELVFEAVSNALREAGIRKQEVDLSITASLDIYDGRSISSGLTNAASGGYLGQSYRLEGDAGQAIVAAAQTIAANDADVVVAVGVYNPEVSTSDRRAFVQQISNYGFEPHFDRPVALSAETVWGLHAGHALGAGLIDRDRLAELAADEISRGATSPHTTRTKAVSASEVLGSDLVNGPLTELMLPADSTGAIAVVLGSLPRARRARTTRAVLTGWGQASGDTTPSGTWLTDPAAPTRRAADEAYRRAGVSAPNDQIGIVELTAPTPALHAPVLGALGLDGPGVVVNPSGGVRSSYPGVANGALRLLEVVHALENSGVGHGVAQSSDPLTGTIADTATVLVVEGV
>NZ_CP016594.1|WP_004023676.1|3958694_3959882_-|AAA-family-ATPase
MNDSKRIVEMRGAKARAERQAEANAKALKFVDENLLTRRQVRDLPTPRWIVSEWLVAQTLASVFGEPGVGKSAVVLDMALCVATGRPWNGRATLPGRVVYLVGEGLTGMEQRISAWEAENNGGREVSGLYLFRASLPLIDGDPRTDALVEKMATIRPSVIVVDTQARYTVGLEENSATDQGKFVDYLDDLAEASGSCILVVRHAARGTSHARGSTALEGAVETEIHVDRDKRKADTLGTITLTKQKNGPDGMSAEFAMVAAHGSVVVKVGGDVPRKFVGGDPFASPRIVTPRDSHARRLAWICWVNWREATTGFTRDNARKALQDSPLRIRRDSFYKAWSRLERDEYVEAVTGSSRFKVTEKCIDTEGFTQDMASEYERQEAYLTPESEASDADE
>NZ_CP016594.1|WP_004023677.1|3960157_3960370_-|helix-turn-helix-domain-containing-protein
MSTRTSTPPDIDQLRHVPTVSVEEAGRYLGVSRAFAYTMVRNGDLPVIRLGTRRVRVPSAKLLRMLGVEA
>NZ_CP016594.1|WP_110117435.1|3960424_3960973_+|hypothetical-protein
MRTPRKQRTGDVTDVRRVEGGLGDLFGILVVLAGHAHSYVVRVVTGKGGPRLVDLQIRSDADAAITPETLRAIPSRRLAHAAAQFAATADGQMATPAMVRDPESQTRPGERTARGKLSDAHYEEVAQRVRAAVLGGFPVRKTVSADMGTSIQTLDRWIRRAKDLGYLDEDELPRRKNPETNP
>NZ_CP016594.1|WP_004023679.1|3960969_3962205_+|site-specific-integrase
MTENQRQRGHRADNSVRPNMATVTVNGQKKNVQKGWRARPTLGTDPVTGKQVRPTKVFPTKKAAQEWVDEQREQWRGRTWAAKSDRTFDDVADHWIKIREADDRVRENTVRADRESLAYARRTFGQVAVQKLTPEALTEWSLTMTTKHGTNADGTPRPGKALAPSTKRRAIVSVKSVMAHAVTMKWIPYDPSAHLQAPEQKVIVAVAEGDIWTPAQMTEFLDYVADHRLSGCFALTLLGLRREEVGGLRWCDLDLEAGELRIRQARVDVNGREVIADPKNSRSVRDLPVPPRELAMLKAMRTHHLRERLAVGRPLVEEDLLLSRIDGTPLPVREYTRLFTDRRKAAKLPPITLRNLRHSSVSRMRAAGVPADVVAAWHGHSERMTQAVYGRVTDDRLAAAAVVLSNAVGQS
>NZ_CP016594.1|WP_004023680.1|3962486_3963239_-|DsbA-family-protein
MSKKRKPGASVPRTSNSKYQPSAPSNTMTYVLGGVAILVIAGLVIGGIWWSGRGKGETDQAALASSSTMIVGPETAPLIDVFEDPMCPVCKVFEQQSGPAITKAVTEGKLRVRYHTLHFLDSRSATGDYSSRAAGALACVADEQNTDLFLRFHSALFAAQPPEDGTGNITSPELARMATEQGATPATATCITDNAKVAQAKETAQKSTDELSKATGGQVGTPTVLHDGEPVDGVLEGNAWLDSILGGGNS
>NZ_CP016594.1|WP_033205641.1|3963321_3964965_-|alpha-D-glucose-phosphate-specific-phosphoglucomutase
MAHPRAGTLALPEDLVDVDALVRAYYDNTPDPSDPLQQVVFGTSGHRGSSFDNAFNEAHILATTQAIVDYRRSAGISGPLFIGFDTHALSVPAWRTALEVLAANEVTVYTAESDSFTPTPAVSRAILTFNRDNPGVLSDGIVVTPSHNPPRDGGFKYNPPTGGPADTSITSVVAARANELLEQKLDGVARIPFDRARSGDYVQDYSFLLNYIDGLGDVVDMKAIHDAGIRIGADPLGGASVGYWALLGLRYNLDHLTVVNPTVDPTFSFMTLDTDGKIRMDCSSANAMASLISARDSYDIATGNDADSDRHGIVTPDAGLMNPNHYLAVAIDYLFTHRPQWSESAAVGKTLVSSSLIDRVVAGIGRPLLEVPVGFKWFVDGLLNGRVAFGGEESAGASFLTFDGSPWSTDKDGIIMALLASEILAVTGKTPSQRYAELAEEYGTTAYARIDAPASREQKAVLSKLSPEQVTATELAGEPISAIMTSAPGNGAPIGGLKVTTENAWFAARPSGTEDVYKIYAESFKGAEHLAQVQQEAQQVVDAALGS
>NZ_CP016594.1|WP_033205684.1|3965086_3965722_+|prolyl-oligopeptidase-family-serine-peptidase
MLISGLPGLLSPGRRSPSLLVLVLPGGTDNSRTPFSPWQPSALRMYPFTWSLRLRFGRSVRVHQVGYRVYGWNGDENSPMLPARAALDEMCRRHPGVPVVAIGHSMGGRVAAHLAADRRVIGVLGLAPWWQFADWRHIQPGARVVAVHGDADTRTLAKRTRKGIDELSTQGVDAEFIPVPDGGHAMLDHIGLWQRSALDFVGERLSALRPA
>NZ_CP016594.1|WP_004023683.1|3965726_3967511_-|long-chain-acyl-CoA-synthetase
MVDHASGTGLLPDIRLADMMSGVASLRGDAGTILRTLPQMLPKPPTTKMSIGKRFQQSVDKYPDRDFLRFEGTSITYRDANARANRLADFLIREGVGRGDVVAVLSRNHPDVVITMLAIVKTGAICGMLNYNQRGTVLEHSLGLIEPKVVLYERDLLEALESVPAGCRPAKEFTFDELATLTARCSPLDLAVTESIEVGSTAIYIFTSGTTGYPKASKMSHYRWLVAMNGIGGLGIRLRGDDVMYTALPFYHNNALTISVSSVLASGACLAIGKQFSASKFIDEVIENDATAFAYIGELCRYLLAQPPKPTDRAHRLRLAVGNGLRPDIWDAFTERFGIDRIVELYAASEANIGFINVFGLSKTAGFSPLPYTIVEYDEETGEPLRGPDGRVKPVGRGGTGLLLAQINSRVPFDGYTDPKATERKIVRDAKRKGDKWFNSGDVVRDQGFSHIGFVDRIGDTFRWKGENVATTEVEAVLDAHPAVEEAVVFGVPIPGVDGKAGMAAISLQDGESFDADGLARHVRTGLPAYALPLFVRIVPQLEHTSTFKNMRTELRKQGYAETGDDPLYVLAGEKYVEFYPEFVDELAGARRKG
>NZ_CP016594.1|WP_033205687.1|3967707_3968940_+|CoA-transferase
MTDTSRPMSERPAGPLDGVIVLELGTLIAGPHAARLLGDMGAEVIKIEAPGKPDPIRTWGQAEVDGHRFYWTVHGRNKKAVTLDLRSDRGRELFLGLAERADVVVENFRPGTLERLGIGPDVLSAHNPGLVVVRVSGYGQTGPDSTRAGYASVAEAASGLRHLNGYPGQLPPRIALSLGDTLAGMFAAQGALAALYRRSVTGRGQVVDTSLIESCVAVQESAIADYDAGGVVRGPSGTRLDGIAPSNLYPTSEGTHVIIAANQDSVFARLCAAMGQPELATDDRFADHAARGRNQDELDALIGDWSRQHSPEKLTEILGAAGVVVGPVNTVAEVVADPHLKERGMIAEHYDERAQRTVLGPGVVPQFSDTPGGIRNAGPPAPGCDNETVYGGLLGLSEDEVAALREAGVI
>NZ_CP016594.1|WP_004023685.1|3968960_3969800_+|ABC-transporter-ATP-binding-protein
MSLVATGLSRTFGRHTAVVDASLELRSGRITGLVGPNGAGKTTLLLLLAGLLAPDTGSITVDDAPVQPTDMRRLTGWMPDIFGTWESLTAREILTTFGKLYGMPTTQARQRAAELLELVHLTDLATRPAHELSRGQKQRLGFARALVHRPRILLLDEPASGMDPRSRMDLRSQLRRLADDGCSILVSSHILSELEEMVDDVVLMTEGRTHAPQGAAGGVWRIRLVGEPPGQARDVRFDDESDAARHLAQLVSSGAAVSEFTPVSTGIEDAYLALDPERR

Crispr_ID: NZ_CP016594_10

• CRISPR_ID: NZ_CP016594_10
• CRISPR_location: 4908233-4908363
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016594_10

Consensus_repeat	Method
CTCAGGGAGCAGAGGGTGGGCCTTCGCTCG	CRISPRCasFinder

spacers of NZ_CP016594_10

>10.1|4908263|71|NZ_CP016594|CRISPRCasFinder
CACCTCAGGGAGCAGGGGTGGGCCTTCGCTCGCTCCTCAGCTCAGGGAGCAGGGGTGGGCCTTCGCTCGTA

CRISPR arrays and Neighbor proteins around NZ_CP016594_10

CRISPR arrays

The CRISPR arrays of NZ_CP016594_10

>merge|NZ_CP016594|10|4908233-4908363|CRISPRCasFinder
CTCAGGGAGCAGAGGGTGGGCCTTCGCTCGCACCTCAGGGAGCAGGGGTGGGCCTTCGCTCGCTCCTCAGCTCAGGGAGCAGGGGTGGGCCTTCGCTCGTACCTCAGGGGCAGGGGGCGGGCCTTCGCTCG

>NZ_CP016594|10|9|4908233-4908363|CRISPRCasFinder
CTCAGGGAGCAGAGGGTGGGCCTTCGCTCG	CACCTCAGGGAGCAGGGGTGGGCCTTCGCTCGCTCCTCAGCTCAGGGAGCAGGGGTGGGCCTTCGCTCGTA
CCTCAGGGGCAGGGGGCGGGCCTTCGCTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016594.1|WP_004022260.1|4897687_4898749_-|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|235533
NZ_CP016594.1|WP_004022268.1|4905725_4906751_+|hypothetical-protein	unknown	unknown	gnl|CDD|239535
NZ_CP016594.1|WP_004022263.1|4900604_4901096_-|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224759
NZ_CP016594.1|WP_004022273.1|4911799_4912987_-|MFS-transporter	unknown	unknown	gnl|CDD|340897
NZ_CP016594.1|WP_033204809.1|4914494_4915484_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238566
NZ_CP016594.1|WP_004022279.1|4917772_4918021_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004022264.1|4901189_4902671_+|MFS-transporter	unknown	unknown	gnl|CDD|129794
NZ_CP016594.1|WP_004022277.1|4915554_4916841_+|lipase	unknown	unknown	gnl|CDD|367570
NZ_CP016594.1|WP_033204807.1|4912983_4913658_-|FadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225097
NZ_CP016594.1|WP_004022278.1|4916849_4917710_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|235853
NZ_CP016594.1|WP_004022266.1|4903590_4904742_-|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173847
NZ_CP016594.1|WP_004022267.1|4904895_4905729_+|CoA-ester-lyase	unknown	unknown	gnl|CDD|225184
NZ_CP016594.1|WP_004022265.1|4902807_4903554_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225099
NZ_CP016594.1|WP_081487030.1|4899738_4900563_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187589
NZ_CP016594.1|WP_004022271.1|4909566_4910355_-|hypothetical-protein	unknown	unknown	gnl|CDD|239527
NZ_CP016594.1|WP_004022272.1|4910351_4911722_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274593
NZ_CP016594.1|WP_004022275.1|4913721_4914372_-|thioredoxin	unknown	unknown	gnl|CDD|372611
NZ_CP016594.1|WP_004022269.1|4906796_4907936_+|dehydratase	unknown	unknown	gnl|CDD|211976
NZ_CP016594.1|WP_033204838.1|4908384_4909338_-|multidrug-DMT-transporter-permease	unknown	unknown	gnl|CDD|131461
NZ_CP016594.1|WP_004022261.1|4898852_4899725_+|siderophore-interacting-protein	unknown	unknown	gnl|CDD|99790

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016594.1|WP_004022260.1|4897687_4898749_-|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|235533	PRK05617, PRK05617, 3-hydroxyisobutyryl-CoA hydrolase; Provisional.	1.55252e-159
NZ_CP016594.1|WP_004022268.1|4905725_4906751_+|hypothetical-protein	gnl|CDD|239535	cd03451, FkbR2, FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The function of FkbR2 is unknown.	1.89515e-34
NZ_CP016594.1|WP_004022263.1|4900604_4901096_-|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|224759	COG1846, MarR, Transcriptional regulators [Transcription].	3.72271e-09
NZ_CP016594.1|WP_004022273.1|4911799_4912987_-|MFS-transporter	gnl|CDD|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.87103e-111
NZ_CP016594.1|WP_033204809.1|4914494_4915484_+|ABC-transporter-substrate-binding-protein	gnl|CDD|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	2.53132e-37
NZ_CP016594.1|WP_004022264.1|4901189_4902671_+|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.49363e-46
NZ_CP016594.1|WP_004022277.1|4915554_4916841_+|lipase	gnl|CDD|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	5.05646e-39
NZ_CP016594.1|WP_033204807.1|4912983_4913658_-|FadR-family-transcriptional-regulator	gnl|CDD|225097	COG2186, FadR, Transcriptional regulators [Transcription].	4.98706e-49
NZ_CP016594.1|WP_004022278.1|4916849_4917710_-|SDR-family-oxidoreductase	gnl|CDD|235853	PRK06701, PRK06701, short chain dehydrogenase; Provisional.	1.03081e-135
NZ_CP016594.1|WP_004022266.1|4903590_4904742_-|acyl-CoA-dehydrogenase	gnl|CDD|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	8.41098e-136
NZ_CP016594.1|WP_004022267.1|4904895_4905729_+|CoA-ester-lyase	gnl|CDD|225184	COG2301, CitE, Citrate lyase beta subunit [Carbohydrate transport and metabolism].	1.48076e-53
NZ_CP016594.1|WP_004022265.1|4902807_4903554_-|GntR-family-transcriptional-regulator	gnl|CDD|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	7.08166e-41
NZ_CP016594.1|WP_081487030.1|4899738_4900563_-|SDR-family-oxidoreductase	gnl|CDD|187589	cd05328, 3alpha_HSD_SDR_c, alpha hydroxysteroid dehydrogenase (3alpha_HSD), classical (c) SDRs. Bacterial 3-alpha_HSD, which catalyzes the NAD-dependent oxidoreduction of hydroxysteroids, is a dimeric member of the classical SDR family. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	4.05937e-46
NZ_CP016594.1|WP_004022271.1|4909566_4910355_-|hypothetical-protein	gnl|CDD|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	2.80974e-08
NZ_CP016594.1|WP_004022272.1|4910351_4911722_-|FAD-dependent-oxidoreductase	gnl|CDD|274593	TIGR03467, HpnE, squalene-associated FAD-dependent desaturase. The sequences in this family are members of the pfam01593 superfamily of flavin-containing amine oxidases which include the phytoene desaturases. These sequences also include a FAD-dependent oxidoreductase domain, pfam01266. The genes of the family modeled here are generally in the same locus with genes involved in the biosynthesis and elaboration of squalene, the condensation product of the polyisoprenoid farnesyl pyrophosphate. This gene and its association with hopene biosynthesis in Zymomonas mobilis has been noted in the literature where the gene symbol hpnE was assigned. This gene is also found in contexts where the downstream conversion of squalene to hopenes is not evidence. The precise nature of the reaction catalyzed by this enzyme is unknown at this time.	3.5993e-72
NZ_CP016594.1|WP_004022275.1|4913721_4914372_-|thioredoxin	gnl|CDD|372611	pfam13462, Thioredoxin_4, Thioredoxin.	5.9615e-16
NZ_CP016594.1|WP_004022269.1|4906796_4907936_+|dehydratase	gnl|CDD|211976	TIGR04253, mesacon_CoA_iso, mesaconyl-CoA isomerase. Members of this protein family belong by homology to the family of CoA transferases. However, the characterized member from Chloroflexus aurantiacus appears to perform an intramolecular transfer, making it an isomerase. The enzyme converts mesaconyl-C1-CoA to mesaconyl-C4-CoA as part of the bicyclic 3-hydroxyproprionate pathway for carbon fixation.	1.36443e-105
NZ_CP016594.1|WP_033204838.1|4908384_4909338_-|multidrug-DMT-transporter-permease	gnl|CDD|131461	TIGR02408, putative_L-proline_4-hydroxylase, ectoine hydroxylase. Both ectoine and hydroxyectoine are compatible solvents that serve as protectants against osmotic and thermal stresses. A number of genomes synthesize ectoine. This enzyme allows conversion of ectoine to hydroxyectoine, which may be more effective for some purposes, and is found in a subset of ectoine-producing organisms.	1.70339e-105
NZ_CP016594.1|WP_004022261.1|4898852_4899725_+|siderophore-interacting-protein	gnl|CDD|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	6.11707e-57

Protein sequences

>NZ_CP016594.1|WP_004022269.1|4906796_4907936_+|dehydratase
MSSNPRPLEGLRVVEVSSFVASPLCGLTLSQLGAEVIRVDPIGGGADVNRWPLTADGHSIYWTGLNRGKKSVTVDFRDPGGQKSVQDLVIDSGPGGGILVTNAGGRSWMSHETLSARRSDVITLELLGRTDGTPGVDYTVNAALGFPAITGPTDYAGVVNHALPAWDIACGLYAALAITAAVRRREQTGSGAQITLPLEDTALAIAGALGYLTEPQLGGGTRPATGNDVYGTYGTDFVAADGGRFMLVALTPRHFRGLVEMTGTGDAVAAVERALGADFSTEDDRYIHRGVLTPLFAAWFARHTTAEVEAGLATASVLWERYRTFDEVVESGVLERNPLFGELDQPGIGTYLAAGLPARFDGAHLFAGPAPDLGSSSGF
>NZ_CP016594.1|WP_004022268.1|4905725_4906751_+|hypothetical-protein
MTSPDRTGSEAIAVGGPYFDELCHGQVFDDAPSLTVTDGLAAAHQMILGDRLRLALDAHLSDRVIHGGTLAHPGLITDIAIGQSTLATHHVKANLFYRGLRFLSHPRIGDTLTTATEVVGLRENKSKPGRAPTGLAALHMVTTDQHGATVLDFYRCAMLPLSPDADPGRTVHMDDLSTIGPGTDVPPFLPEWDLAVYRTSARGQHFSPDLAGRSFTSSADVVSSAPELARLSLNIAATHHDERVAGAAAGGRLVYGGHTIGLALAQANRALPNLVTVIGWDSCDHTGPVHEGDTLSSTILVEEATPLATGGGVLRLRSTVVAHGVDADRDVLDWRFRVLMA
>NZ_CP016594.1|WP_004022267.1|4904895_4905729_+|CoA-ester-lyase
MQRRRAVLVAPASDDRKARKALGSIADEVVLDLEDAVTPPNKDSARAAAADLVAEFGAERAISLRINAIDTPWAAADLAACAQMPNLSSVVLPKADSPADLRSADEQLGRAPVRLQALLESPRGIRDAGAICAATTRLDAVLIGYADLAASLGRSSGLPMQTWHVVQDSVLLAARAAGVDVIDGPHLTIADDDTFRDAKRWVRDLGFDGTWVIHPAQLQSAIEIFTPDAGAVEDARRVLDALEKAAAAGAGAAELDGRMLDEALAVSARRVLAKAAE
>NZ_CP016594.1|WP_004022266.1|4903590_4904742_-|acyl-CoA-dehydrogenase
MSTLSAEESFLVDTVRSFVDREVRPSVQEVEHANSYPEKWIDQMKQIGIYGLAVPEEFGGSPVSMPCYARVTQELARGWMSLAGAMGGHTVVAKLLTLFGTAEQQQQYLPRMATGEIRATMALTEPGGGSDLQAMTTVAKVDGDDLVISGSKTWISNARRSGLIALMCKTDPGAQPRHRGISIVLVEHGPGLTVSRDLPKLGYKGVESCELSFDGYRAPRSAILGEVPGKGFGQMMKGLETGRIQVACRALGVATAALEDSLAYAQQRESFGQPIWKHQSIGNYLADMATKLTAARQLTWHAAEQYDKGERCDMEAGMAKLYASEVAMEIALNAVRIHGGYGYSTEFDVERYFRDAPLMIVGEGTNEIQRNVIAAQLVSRGGI
>NZ_CP016594.1|WP_004022265.1|4902807_4903554_-|GntR-family-transcriptional-regulator
MDEPDQSAPAYKTLAAELRSQIVAGRYAGGVRLPTESELSQEHGLSRQTVRRAFLELVTEGSVYRVPGRGTFATENAGQYLRQLGSIEDLMNLSADTEMQVLEAPARRVDLEAAGRLRLDTDVAYRIVFQRFHDGVPFVVTTVWWPESVARLVIDAPEVEAGARSEHTMIGLLEPHLVHPIEECAQSITATVADAGTAARLGCPVGHAVLRVDRLYTDSRGRAVELAVSHFLPEHYTYRVTLRRRSAP
>NZ_CP016594.1|WP_004022264.1|4901189_4902671_+|MFS-transporter
MGQVRGSAPELTDDASDAIEMAPAGAIGSVVVLCFGGLVASLMQTLIIPIQPDLPRLLGTSIGNASWIITATLLAAAVAMPIAGRLGDMFGKQRVLLVSAVLLTLGSLICALGDSLIPLIIGRGVQGLAMGFIPVGMSLIREITPPRITSMAVAAMSATLGVGGAIGLPLAAWIVQTWNWHALFYVAAGLGVLVTLAVLILVPRVNDAAGGRIDIPGAIGLAVGLSAFLIAVSKANDWGWTSGATLGLGIGGIVVLVGWGFVELRRSEPLVDLRTTARPAVLLTNIAAAAIGFGMMAQSIVLPMLLRLPEATGYGLGQSLLAAGLWMAPGGLMMMIFAPVSGILINRIGAKITLAIGAAILGCGYLLAFFLMDAAWKLMLASIVCAIGVGVGYAAMPTLIMGSVPATEAGAAVGLNGLMRSLGTTIASAVMALILASATISLGGTEVPDESTFTWCFLVAAAAAFVGMAITLTIPSRRGSSNVPEEQPLPARG
>NZ_CP016594.1|WP_004022263.1|4900604_4901096_-|winged-helix-turn-helix-transcriptional-regulator
MSEDHAPWQSPVHRDLAQELLRMSRRRSLVHPGVGLERSAFAILWVLSDGRPRTLRELTADLELEQSTVNRQVNAAIKHGYVERFEVEDSLSKMIRPTESGRAAFRRDGLLRAERLEQVFADLAPGSPQALLDELRAFNDAYERTQHRHGATDESDTGKKGSA
>NZ_CP016594.1|WP_081487030.1|4899738_4900563_-|SDR-family-oxidoreductase
MGASVAAALRAEGHTVIGVDQRDAEVIADLSTPEGRRGAADEVLARSGGRLDGAVLAAGMGPAAGREREIVEVNVFGVTDLLTAWRSALAAGTKSKVVVFGSNSTTVTPLVPMSAIRRLLNDDPEGATRVIRRRRGVTGPVAYASSKIAITQWCRIHGTAAEWAGAGIRVNVIAPGPVMTPLLQSQLDSPQGGHVKSFPVPVREYGTPGQLASWVLLMLSPAADFMAGAVVTVDGGTDALMRARDWPSRLPLRAVPRFLWTMYRAPRRGMVAEY
>NZ_CP016594.1|WP_004022261.1|4898852_4899725_+|siderophore-interacting-protein
MGYSRARVADVADLTPNLRRIVFDVADLPGLGLPGGADEAVGIYFPHDPERVTPDMECRDGTWAYYDIDPAPDGRNYSIRSVDHSACTMVVDFVIHAAGPATLWAQRAEAGHDVVMTHARSWYAPPAGVERLILAADLAGLPALARILDELPSTDGVTAVVEVPAPSELSYLPERDVELITLVGGNSRTPSRLADTVCGLTLPDSGAYCWFAGEAAESRAIRKHLRGNLRWDRGSYDVIGYWRVDAERWTQAYVQRGAELFAVYRQALEDGKSEKQASEEFDEALERAGL
>NZ_CP016594.1|WP_004022260.1|4897687_4898749_-|enoyl-CoA-hydratase/isomerase-family-protein
MSEPSVVTEKNGSARSLVLNRPKSINAIDHEMVGSMAEHLAAWADDDAVEAVVLSGAGERGLCAGGDIVAIHRDASALSGNPESTDRDAEQSPSAKFWFDEYRLNALISGYPKPYVAIMDGIVMGGGVGVSAHGDIRVVTDRTKLAMPEVGIGFVPDVGGTHLLSRVPDGLGTYAGLTAGHLRGADAIAMGLADHFVPSESLPAFLAAIGESGVEAALSAHAVDAPASELAEQREWIAEAFAADNVSEIIERCRAIGTPFADKTADAIAAKSPTALAVTLRSLREAAGDATLEDTLVREFRVSVRCLLHPDMAEGIRAQVIDKDRNPKWAAFSEDAVDAFFAPLPDDLTFGER
>NZ_CP016594.1|WP_033204838.1|4908384_4909338_-|multidrug-DMT-transporter-permease
MTTHTATTMPDTAGTSAAPTVSAGARSTSVGVDVYRTRLAHHSQIEPRPHNTVWGSMGNPGPLSAPELRRYADRGYHTETNVLADGDIAECLREVEAITERLGDDDRVIRESSSGDVRSLFAAHQLSDVIAEICARESIVGVARQILDDDVTIHQSRINLKPGFAGGPFYWHSDFETWHAEDGMPAPRALSVSLALTPNVTTNGPLMIIPGSHRRFVSCVGSTPGDYHRESLTSYRPPFGTPEEQDVASLADELGIDTITGPAGSALYFDSNCLHASGGNITPYPRSNLFVVFNAKSNALQEPYGGTAPRPDHLAHR
>NZ_CP016594.1|WP_004022271.1|4909566_4910355_-|hypothetical-protein
MTTSASAFHLGGPEVMLRIGEVSVSGERSEAHTEAGPWLADPAAGVSRGALAVSCDDVTGYLVAAGGPRHRWPVSLGIRMDFLADPPLDGSSLHVSGELVARDDRGAMTTGAVLDPSGRTIATIIQRSHLIDAPRTPGPRASARVLEIPDEPVRQQLGLVEVAPNVLSMAPTVLSANGMGSVHGGILVCASELAAASCVRAAGDMRTTSVDITYVRPCDAAETATFTSEVMHHGRSLSVVRVVAANRGAKPAAIATVVLQHI
>NZ_CP016594.1|WP_004022272.1|4910351_4911722_-|FAD-dependent-oxidoreductase
MHCVVVGGGLAGLASAVWLSEAGQRVTLLERRGSLGGRTISMPLHVVDDVPDNGQHVFASGYEHLMRYLDSVGTRRHVAFPGHMTVRMPGGATRRSGFAGVSGLRAALGDLPGVTGLDRLRTARAQITLIRQAFRQPDWLDDITADEWFRRIGMPQSARDALWDGIVIGLTGDKPDISSAKVPADLLVTGARRARETRTPISIGYPTVDLDTLFIEGAEKRFADAGVEVRHRAVVSSIDVTDGVVSGVTLADGEKIAADAVICAVPVWSVKGLLDQVPGHDRIYRAVENLTPVPIVSVNLYLDRSIGMADWGEILYGGEGVLEQVWDRQRMHGRESRDNHFYSTTVSASYELISKTNAEITEIQMDMLRRYFPQAADAEVVHSHVVRMPKSTFAQRPGTFGLRPDQRTEVDGLALAGDWTRTDWTTTMEGACQSAARAVDIILEHAQRRRQGARQP
>NZ_CP016594.1|WP_004022273.1|4911799_4912987_-|MFS-transporter
MSGRGLSTHERTGIGVIVTAVGVMLVAANLRPAVVAVGPLIGVISDDAGFSSAVAGLLTALPVLFFGISAPVAPRLANRFGIERVIFGALLVLIAGILVRLIPSAAALFAGSAIIGAAIGTCNVVLPALIKRDFAHRSGLMTGLYSMTLSGGAAVASGVSVPTNDALGGDWRLALATWGLLAVVAVVVWIPQLPSVHRVTSASPTTSLLTNPIAWAITVFMGTQSLIFYTFVAWLPQYLVETGMSPLRAGAVLASAQVVALIMSLLAPIVAGRFADQRVVTLSVITVCAIGFVGLLSTDVWPGFWAACVMVGPGSSISLALLFMVLRSSGSEQTGQVSGMAQSVGYLAAAAGPIAIGGIHDVTGSWTLAMAVLGLVLVPQAVSVLGAAKNVKMTG
>NZ_CP016594.1|WP_033204807.1|4912983_4913658_-|FadR-family-transcriptional-regulator
MTGQIIPPRRTSELVVQRMQELIADGTWPIGERIPAEPELVAQFGVGRNTIREAARALEHAGMLEPRRGDGTYVRGRSPLAGAIARRSAPSELRDLLEVRRALESEAAAGAAGRGDARDVERLRTLLARTEDALTDGDLDRYTQADIAFHAELVLASRNVLLIEMYDGIAEAIARTHPSVLRRPLAEQSHPRGHRDVVDAIERGDAVAARAAVYAYVDFTEVPE
>NZ_CP016594.1|WP_004022275.1|4913721_4914372_-|thioredoxin
MSRPTKIAWAALVAIVVVLGVAVLIDREPAPAPADTTVAVDRLVRPDSHRLTAPADERARFVEFLDFECEACGAVYPIIEDLRRTYGDRIAFVVRYFPMPGHVNAERAARAVEAAAAQGRFEQMYQRMFATQAHWGEQRVPADDVFRGFAIDLGLDMPAFDAAYNSPATLERIRADVADGLALGVQGTPTFFLDDQRLMPNTIDDLTGALHRAATA
>NZ_CP016594.1|WP_033204809.1|4914494_4915484_+|ABC-transporter-substrate-binding-protein
MHPKRYLAAPFLLVAVLVFALGCSSGNDGNSGKNSTESTGSTTVDHQYGSTVVEGTPERVVTLTGATAWSDSLIRLDVPITAEFVSTGYSGPGNRFAWTPPHESTVIPVDVGASPGVAEIAKLDPDLILAGYLPDRAAYDILAKIAPTIPVMSTETVNDTWQQVLSTAGKIFDKEEQAAEAQTEVEAKIDAVKKKYPAAQGKTATFGQLTPERQFGVVTSDNDPSAKLLAEVGLRLDPAVTGLSDNGQRVVVSSERVDLLGSDLLIFWPLVGGPEVFGTIPGWDSLTAVRSGATVFLTNDTASAFGSPTVYSVPWAVDALEPALAKLTT
>NZ_CP016594.1|WP_004022277.1|4915554_4916841_+|lipase
MSFGVRTSWLRVGVIGLVVGVIAGVLASAPPAQAAPGPGSPLPSADPFYSYNGSLAGVAPGAVLRSRPMQFRTPTLSTPITGSQVLYRTTDQFGESVVTVATVLRPLTPGPTRLVSYHMAYDALGSQCDPSYTLSGGYTNGTATAEQGVIAGYLAAGYTVVVPDYEGEKLQWTIGRQSGYAALDGVRAAQSFLRLPRSTPVGLVGYSGGSIPTQFGAEVAPRYAPELNIVGAAAGGLPVDLAHNLPYINGSAKWAGVIPALVVAYQRTYRLDTSTFLSARGKQVAQDVSDECISGFASKYAGLTSADMVKPPYTGLLDVPQVVRAINDNIMGRSGTPSTKMLLAVGHYNAIGDTLMITGDVIGLANEYCSRGVDITYRQINGLTHQEAFLPFEPLALQYLTERFAGAPTQSNCGSLPRGNSLAPLPVP
>NZ_CP016594.1|WP_004022278.1|4916849_4917710_-|SDR-family-oxidoreductase
MSDENPEHVAKTIPYPGETDEMGDRPRDEMREYRGRDLLMGKTALITGGDSGIGRAVAVAFAKEGADVAIAYLEEDNDARHTVELIEAQGRQARAYRGDLADPAHCTDIVRRTVDELGALDILVNNIAYQEIVDDFLELTPEQWRRTFAVNIDSFFHTTRAAVPHLTGGGAIINTSSINGLRGNDSLIDYSATKGAVLALTYSLAQSLMERKIRVNCVAPGPVWTPLIPATMPADAVKDFGTQAPMGRAAQPDEIAPSYVFFAAEQLSSYYTGEVLAPIGGETLPG
>NZ_CP016594.1|WP_004022279.1|4917772_4918021_-|hypothetical-protein
MSTDNVGDSATAATEGINPDLTSTAGFEDLDEDRLGRDPLEEGMDPPEDWSASDRTGTTAREQREGESLDDKLDQEIPDEHP

Crispr_ID: NZ_CP016594_11

• CRISPR_ID: NZ_CP016594_11
• CRISPR_location: 5022164-5022295
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016594_11

Consensus_repeat	Method
CCACCCCCGCTGGTTGAGCAGGCGACGAGCGCAGCGAGGAGCCGTGTCGA	CRISPRCasFinder

spacers of NZ_CP016594_11

>11.1|5022214|32|NZ_CP016594|CRISPRCasFinder
GCAAGCGCCACCCCCAACTGATCGAGCGAGCG

CRISPR arrays and Neighbor proteins around NZ_CP016594_11

CRISPR arrays

The CRISPR arrays of NZ_CP016594_11

>merge|NZ_CP016594|11|5022164-5022295|CRISPRCasFinder
CCACCCCCGCTGGTTGAGCAGGCGACGAGCGCAGCGAGGAGCCGTGTCGAGCAAGCGCCACCCCCAACTGATCGAGCGAGCGCCACCCCCGCTGGTTGAGCAGGCGACGAGCGCAGCGAGGAGCCGTGTCGA

>NZ_CP016594|11|10|5022164-5022295|CRISPRCasFinder
CCACCCCCGCTGGTTGAGCAGGCGACGAGCGCAGCGAGGAGCCGTGTCGA	GCAAGCGCCACCCCCAACTGATCGAGCGAGCG
CCACCCCCGCTGGTTGAGCAGGCGACGAGCGCAGCGAGGAGCCGTGTCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016594.1|WP_081487026.1|5018016_5019270_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270271
NZ_CP016594.1|WP_004022387.1|5025159_5027514_-|endopeptidase-La	unknown	unknown	gnl|CDD|223542
NZ_CP016594.1|WP_004022373.1|5011517_5013362_-|molecular-chaperone-DnaK	unknown	unknown	gnl|CDD|234715
NZ_CP016594.1|WP_004022377.1|5017231_5018020_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|223673
NZ_CP016594.1|WP_004022388.1|5027578_5028205_-|hypothetical-protein	unknown	unknown	gnl|CDD|319914
NZ_CP016594.1|WP_004022380.1|5019886_5020921_-|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl|CDD|224871
NZ_CP016594.1|WP_004022394.1|5031890_5032796_+|hypothetical-protein	unknown	unknown	gnl|CDD|226651
NZ_CP016594.1|WP_033205227.1|5031200_5031794_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NZ_CP016594.1|WP_033204834.1|5019176_5019911_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224041
NZ_CP016594.1|WP_004022381.1|5020926_5021454_-|DUF4242-domain-containing-protein	unknown	unknown	gnl|CDD|379428
NZ_CP016594.1|WP_004022391.1|5029061_5030534_-|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl|CDD|129794
NZ_CP016594.1|WP_004022374.1|5013722_5014871_+|hypothetical-protein	unknown	unknown	gnl|CDD|226326
NZ_CP016594.1|WP_004022392.1|5030576_5031143_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004022386.1|5023307_5025089_+|DUF222-domain-containing-protein	unknown	unknown	gnl|CDD|367155
NZ_CP016594.1|WP_004022375.1|5014867_5015974_+|DUF1214-domain-containing-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004022389.1|5028266_5028449_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004022376.1|5015970_5017218_+|sulfotransferase	unknown	unknown	gnl|CDD|379204
NZ_CP016594.1|WP_004022390.1|5028645_5029065_+|hypothetical-protein	unknown	unknown	gnl|CDD|226720
NZ_CP016594.1|WP_004022384.1|5022387_5023206_+|DUF1353-domain-containing-protein	unknown	unknown	gnl|CDD|377774
NZ_CP016594.1|WP_004022382.1|5021555_5022161_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016594.1|WP_081487026.1|5018016_5019270_-|ABC-transporter-substrate-binding-protein	gnl|CDD|270271	cd13553, PBP2_NrtA_CpmA_like, Substrate binding domain of ABC-type nitrate/bicarbonate transporters, a member of the type 2 periplasmic binding fold superfamily. This subfamily includes nitrate (NrtA) and bicarbonate (CmpA) receptors. These domains are found in eubacterial perisplamic-binding proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. These binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	7.75122e-72
NZ_CP016594.1|WP_004022387.1|5025159_5027514_-|endopeptidase-La	gnl|CDD|223542	COG0466, Lon, ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP016594.1|WP_004022373.1|5011517_5013362_-|molecular-chaperone-DnaK	gnl|CDD|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_CP016594.1|WP_004022377.1|5017231_5018020_-|ABC-transporter-permease	gnl|CDD|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	2.77434e-54
NZ_CP016594.1|WP_004022388.1|5027578_5028205_-|hypothetical-protein	gnl|CDD|319914	cd07251, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.57026e-11
NZ_CP016594.1|WP_004022380.1|5019886_5020921_-|acyl-CoA/acyl-ACP-dehydrogenase	gnl|CDD|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	5.63388e-18
NZ_CP016594.1|WP_004022394.1|5031890_5032796_+|hypothetical-protein	gnl|CDD|226651	COG4188, COG4188, Predicted dienelactone hydrolase [General function prediction only].	4.01501e-19
NZ_CP016594.1|WP_033205227.1|5031200_5031794_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.02622e-09
NZ_CP016594.1|WP_033204834.1|5019176_5019911_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	3.15686e-87
NZ_CP016594.1|WP_004022381.1|5020926_5021454_-|DUF4242-domain-containing-protein	gnl|CDD|379428	pfam14026, DUF4242, Protein of unknown function (DUF4242). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 90 and 170 amino acids in length. There is a single completely conserved residue C that may be functionally important.	1.34979e-25
NZ_CP016594.1|WP_004022391.1|5029061_5030534_-|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	7.07624e-72
NZ_CP016594.1|WP_004022374.1|5013722_5014871_+|hypothetical-protein	gnl|CDD|226326	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown].	1.94288e-32
NZ_CP016594.1|WP_004022386.1|5023307_5025089_+|DUF222-domain-containing-protein	gnl|CDD|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	7.49549e-27
NZ_CP016594.1|WP_004022376.1|5015970_5017218_+|sulfotransferase	gnl|CDD|379204	pfam13469, Sulfotransfer_3, Sulfotransferase family.	1.03895e-29
NZ_CP016594.1|WP_004022390.1|5028645_5029065_+|hypothetical-protein	gnl|CDD|226720	COG4270, COG4270, Predicted membrane protein [Function unknown].	8.70892e-11
NZ_CP016594.1|WP_004022384.1|5022387_5023206_+|DUF1353-domain-containing-protein	gnl|CDD|377774	pfam07087, DUF1353, Protein of unknown function (DUF1353). This family consists of several hypothetical bacterial proteins of around 100 residues in length. The function of this family is unknown.	2.2743e-18
NZ_CP016594.1|WP_004022382.1|5021555_5022161_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.67014e-08

Protein sequences

>NZ_CP016594.1|WP_004022382.1|5021555_5022161_+|TetR/AcrR-family-transcriptional-regulator
MSNPAQASTGRATAAAGPGSPADRLLATATELFAAQGIRSVGIDLLLRASGVAKASLYNAYGSKDGLVVAYLERLDQADQNRWFEATKAMSDPRERILAFFDLAIAGAPTRNFRGCQYANAATEFPDTDLPPITAHRAWLLDTLGDNLRTLGAPEPDVTARQIQVVYDGALSGSKMARSTAPIETGRLLVEALLDGHPPVA
>NZ_CP016594.1|WP_004022381.1|5020926_5021454_-|DUF4242-domain-containing-protein
MALFLYELEPADSDAGKVEELIKGLDAHLRTAGGELIETQVTEGAARLFAIAEFEGCRAAGLDEVEALRGIVAAGPDEVRLVGADLDELKKARPTAGYLVEWDIPEAIDMETYLARKKANSPKYADVPEVSFLRTYVREDTDKCLCFYNAPDEAAVRHAREVVSTPVDRLHRLQG
>NZ_CP016594.1|WP_004022380.1|5019886_5020921_-|acyl-CoA/acyl-ACP-dehydrogenase
MAPTLTDELGEVVASVADRARDLDAGQTDTRVDIAAAGAAGLLGRGVVDGSLASMIDVLERVSAVSLSAGFSLWAQRMAIEYVARSPEPLREQHLASLLSGERIGVTAMAAGLKQVAGLGEVPITGRRGRAGVVATGPIRWASNVYDESLIVLPVRTGDRTLVAVVDADAPGVEIRSAPDLIGLGSTASTSLELVDVTIGAESVISDDLTAFVRGIRPVFLLLQSAFCSGAIGAALDGAVESLAGVNKVFRPEFDDRTAEFESIRERLATFAADPTTPSPADLIRLRLDAARTAVSASRLEATVRGGAGYATASATNRRFRETAFIPIQSPSEGQLRWELAQFE
>NZ_CP016594.1|WP_033204834.1|5019176_5019911_-|ABC-transporter-ATP-binding-protein
MGTRAVRIVGGRKAFRGTSVLTGIDVTVDDGEFVAVLGRSGSGKTTLLRVLAGLETLDAGSLEWQDTSGGPRPHTGVVFQRALLMPWLTVAENIRFGRRFAAHRASFENDYALGLLRRFGLDGLADRYPDQLSGGQAQRVAIIRAAAIRPRLLLLDEPFSALDPAVRGELRSWLAELAAELGITVVLVTHDVDEALELADRIVLLSEAGRIGGEWRLEAGLGRTDPDRRTEILTHFGHQVGQQV
>NZ_CP016594.1|WP_081487026.1|5018016_5019270_-|ABC-transporter-substrate-binding-protein
MAARSRSRPHRSRPAHGDPDALRSPGGAAGVNAPISRRLLVAGVGGLTVAGGIGGIVGLGRAATAAPPSASDALRVGYLPITDAAPLLVAHAAGLYDPAAVSSTKPVLFRSWSSLAEAFVTRKVDVVHLLMPMAVALRYAMRSPVQVLGWNHTNGSALTVAPDIVDLEQLAGAQVAIPAWWSIHNIILQRMLRTHGLRPVIRTGASRGDKTVELIVMSPSDMVPALANGSIGGYVVADPFNAMAQVRKIGRIHTFLGDVWRQHACCALLVHQAAIDERPAAVQSLADSVVAAQHHIDLDRPRAAAELAGGYLPQPKPAIAKALTYDPADFAVSNVDWQPQRLGFQPFPFASFTERLVTEMDNTLVDGDRRFLGRLDPATVHADLVDDRFIRSAIGTRGGAAALGLPADLTRTEQVTP
>NZ_CP016594.1|WP_004022377.1|5017231_5018020_-|ABC-transporter-permease
MMLLTQDETAAAPRRRTGSTVAPPLIAIAVLVAIWWATTTVVPAADSLARQFAPQQVFPAMLELLDRGVLLPDIGLSLWRLSIGLLIAVVLGFPLGLLIGLSLTAERAANPIVAFLRMISPLSWAPVAVMVFGIGNEPVIFLIAIAAIWPIVINTAAGEKSIDPGFVEVARSFHATRTEVLTAVVIPAIRGNVQTGIRVALGIAWVVLVPAEMLGVRSGLGYQILNARDQLAYDQVAALIVVIGILGFVLDAGARLVLTRRR
>NZ_CP016594.1|WP_004022376.1|5015970_5017218_+|sulfotransferase
MTRWAAPERTGTARNIYASAEADRAAHPDRYRLGAQTADGLVERATGEHGVEGLGDPAEWRPGLEQYLESAATDGRLNAVGVRHAQDAAVGKLRARSIFDKTLRTDPAVAQRSIAPPIVIIGGWRTGTTFLFRLLARDPRLRAPRPLELYAPWRAARMTPDERERFVEDQARQPNPLQLLNPSMAAVHDSGPLLPEECVLGMGTTMRNWGFSSTMRLDGYSSWLATQDFAAEYTNHRRMLQILDDGSDRRWLLKAPAHTPELGHLAATYPGVCIVHLHRDIVETVASGASLFATYRSTYSDDVDGHDVGRFQVEQSERWFRRALDFRSSPAAASATILDLDYRDLVASPATMVGRVYAAAGIDPPDVATLLAEHEAAQPRHGKGRHRYTPEEFGIDPDALRERMAFYTDALTVQR
>NZ_CP016594.1|WP_004022375.1|5014867_5015974_+|DUF1214-domain-containing-protein
MSDSTRPEVEAWNGLVDALRTAGDKLASDTAGLSPLEQADGYRALIRGLSNQLSRFDVDRERPELVSFNGWRHKFLMDNPDFRYWVADVRSDRSYRIRGNRGDAVYVSITAYRRTGGIGSGGISSESTARIDSDTIVFDDDGSFEILVGGDAGMDRGADHLDLPEKSSVIWVRFFHDDASRGEAGRCSIEPLAEPPTPPALDPAKFCAQLGTLGTMTSMLPTIFEASTKDDHDPPNTMRHWSEMSGGAVFTEPGIHYVRGGWQLDPGQALVIEGDVVDCRYWNILAYSRFLNSLDFRYRPVSYTGGTATLVDGRYRFVVAAEDPGAGDWIDTEGRDFGIVVMRFLQPADTPALPSARVVGLDELRDAP
>NZ_CP016594.1|WP_004022374.1|5013722_5014871_+|hypothetical-protein
MTPRPPLPDAASPERPLRIAVWGPGEVGGAIIRAAVADPAFDIAGALVHNPKKDGRDIGELVRIDPIGVPATTDRDAIKALDVDCVVVTPAPAAVLKGLDDDVVDLLASGKNVVATAAYHNVSMPNWMSPFRKSPQQLLEACQKGGSTLHGTGVHPTFIVERLAMTMATAMSSVSHVRSVEAVDFTSAGSMWGGLGALGFGADLDSLGPDSPVARGGDLYYGDLTGNVAHALYGSDSSEVRVETSLRGLPAAADAQVGKTTITKGTAAALHLTHRGYLGDHHFFTNEECWYLAAADVVYRGDDLPFGGFTSPIAYTLVVSGEPAEIRTQMEFGVGAGHTNPITTASVRAVLDSIPAIVAAEPGVLIDDIGPHYKHDDRVRLS
>NZ_CP016594.1|WP_004022373.1|5011517_5013362_-|molecular-chaperone-DnaK
MSRAVGIDLGTTNSVVAVLEGGEAAVIANAEGARTTPSVVAFARNGEVLVGQPAKNQAVTNVDRTIRSVKRHMGEGDWTVEIDDKKYTPQEISARTLMKLKRDAESYLGEDVTDAVITVPAYFNDAQRQATKEAGQIAGLNVLRIVNEPTAAALAYGLDKGEKEQTILVFDLGGGTFDVSLLEIGDGVVEVRATSGDNHLGGDDWDQRVVDWLVEKFKSTSGIDLTKDKMALQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLSRSEFQKITSDLLERTRAPFQAVIKDAGISVGDIDHVVLVGGSTRMPAVTDLVKELTGGREPNKGVNPDEVVAVGAALQAGVLRGEVKDVLLLDVTPLSLGIETKGGVMHKLIERNTTIPTKRSETYTTAEDNQPSVQIQVYQGEREIASHNKLLGSFELGGIAPAPQGVPQIEVTFDIDANGIVHVTAKDKGTGKENSIRIQDGSGLSKDEIDRMIKDAEAHADEDRKRREEAETRNQAESLVHQTEKFLKENEDKVPAELKEKVEAAVAGAQEALKGNDTAAIKSAIEKLSEESQALGQAIYANAAAESPNGEAAAADSDPDVVDAEVVDDADSKENK
>NZ_CP016594.1|WP_004022384.1|5022387_5023206_+|DUF1353-domain-containing-protein
MNETTPSDPRWVPWRVAPTSGFEVDDPTRRGEVEIAQIDERQFLVRNAFRFSDSAVEEYLVTQLVERGQTEAHARGAVDAARTFVPGDDNPTDLASIPRFLRWFENPYGRHSLAALIHDELITGTVNSGALGSDTLSDRFFREMMRASGVPWLKRWIMWSAVALRTRWVAGGWRRVSVVAWLVLSVVGICAAVGSSGALLFDWSWPTTSPAVSLLLSLLMIFVAAPLWGRQWAASLIAAVAALWVLPAAIVAYFAYALYLLSERIARSVGLR
>NZ_CP016594.1|WP_004022386.1|5023307_5025089_+|DUF222-domain-containing-protein
MGAWTDLPGEFLAGVDPARPADADTATHMQRLGSIRAGESYLAWCRYQTILVLCDRLLNSVGNSYISDGFGDIVARVSREAGISRYRAGVLVDEALCLRDRLPRVLETLRDGVIGPHQIREIIGRTHLVADDHLLDPADPDSRRIIEVLDEAIAELLRNRAGSWSTSGLRDMIDRLVFGHDADAVRERRREALNNRGVWTENHGDGTGEITAVMAAENIRACDASVRELAASVCDRDGRTLGERKSDAMCALLTRTEFTCACGHSDCTAPPFNPAGATGATAGTEVVIHVVTDADTLAGGSGPGWVDGHGVICDEHVRDLAARPDATIRPVTPVRTPPSHVAGGPAGSGEGGFDDDTGRTANITAPPQGTEDTATGRSGDASTPPAPVTPSTSSEIVVVYPAALPGDPYRPTSACAEFVRVRDGYCTEPGCTRSAFTGDVDHVAEYDHARPARGGATSSENLNAKCRAGHLHKTHGDWTDVQYRDDEGRLVTEFVTPEGFVIPGEAETLEDLFPNLRRIRFEQAAKAPPTPRIIVPDHHGRPPRTITERTAAKHAKRREERARNKTQRDKNRRARTEAAHHQPPTGDDDPPPF
>NZ_CP016594.1|WP_004022387.1|5025159_5027514_-|endopeptidase-La
MSQADRSQTYSLPVLFVPDVVVLPGMVVPIPLDDAAQATVDAARASETGKLLVAPRLDDRYPTYGVIASIVQVGRIPGGGLAAVVKGEQRAQIGTGTPGHGAALWVEVTEAESADITDEDRDLAAEYKKLVLAMLQRREAWQLIDAVNKMSDPADLADTSGYASWLSDEQKRELLETPVTAARLRLLIEWTGDHLAESEVTEKIAEDVRAGMDKQQKEFLLRQQLAAIRKELGEDEPEGADDYRGRVEEADLPEKVREAALREVGKLERASDQSPETGWIRTWLDTVLDLPWNTRTEDSTDVKGAREILDADHHGLDDVKDRIVEYLAVRARRAERGLQVVGGRGSGAVMVLAGPPGVGKTSLGESVARALGRKFVRVALGGVRDESEIRGHRRTYVGALPGRIVRAIGEAGSMNPVVLLDEIDKVGSDYRGDPAAALLEVLDPAQNHTFRDHYLDLDLDLSDVLFLATANVIENIPSALLDRMELVTLDGYTEDDKVAIARDYLLPRQAERAALTPDEVTVTDAALREIAANYTREPGVRQFERLLAKALRKAATNLAVAAGDGGESEPVTIDEPDLRDYLGRPRFTPESAERTAVPGVATGLAVTGMGGDVLFIEVNATEGEPGLKLTGQLGDVMKESAQIALSYVRAHAEQLGVDPKALDKTIHVHVPAGAVPKDGPSAGVTMVTALVSMATGRQVRSDVGMTGEVTLNGRVLPIGGVKQKLLAAQRNGLKTIFVPQRNEPDLDDVPAEVLDALDVRPMTDVAEIVAQALEPAVGEQVSAA
>NZ_CP016594.1|WP_004022388.1|5027578_5028205_-|hypothetical-protein
MTNINALTLEVPDTATAQTFYDKAFGLGDRLRFRTGDSPTSGFRGFVVSLVVADPTVADSFLQPAIEAGATVLKPAKKSFWGYGGVVQAPDGTIWKVASSSKKPSGAPERQVDDLVLLLGVDDVAATKEFYVSRGFVVAKSFGRKYVEFESAPDSIKLALYGCKAAAKDAGVQPDGSGSHRLVIGGDVGELTDPDGFAWAVTPRSLLA
>NZ_CP016594.1|WP_004022389.1|5028266_5028449_-|hypothetical-protein
MTLDTAPSHHFSASWVDSVSGALKGAAGVVVTTAAFLVAIAVLVIAQVVVVATRAAADLT
>NZ_CP016594.1|WP_004022390.1|5028645_5029065_+|hypothetical-protein
MSILTPTTTRQPLGRAIARIALGAILAIAGVGHLTAQREEFQAQVPDWVPFSKDFVVLASGGVEIALGAALIALPRHRKVVSWIVAAFFVAIFPGNINQYVEHIDAFGLDTDQKRLTRLFFQPLLVIWAIAAGTGERRT
>NZ_CP016594.1|WP_004022391.1|5029061_5030534_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MTDPSPAAAESRGVPAASRAGRWLIVAAVLGSGVAFIDGTVVNVALPAIARDLDTGLRGQQWVLDGYLLTLSALLLIGGVAGDRYGRRLVFAGGLAVFAVATVACGLAPTVELLVAARIVQGIAAAAVVPGSLALINAEIQPADRGAAVGLWAGMSGATTALGPFLGGWLVDAASWRWTFLLSVPLALGALWIAIRHVPESRGTPSSARLDVAGALAMTVGLAGVIYALIEGPSNGWSGETVAAGIVGVVSLAGFVVIESRVAAPLLPLRLFRSSQFTGANLTTLLVYAALGGALFLLALQLQQSLGYSAFEAGAAMFPSTFIMLFGSPLVGTLAQRIGPRLPMTVGPLIAAGGFALMSRVEPGSGYVDAVLPGVLLFGLGMTVTVAPLTSAALAAVDDALAGTASGVNNAVARLAGLLAVAVLPAVAGIDAGPGDPLGDGFRAAMYICAACCAVGGIVAACTIRSSTEVHPQVRAGVDAACQDAATRAG
>NZ_CP016594.1|WP_004022392.1|5030576_5031143_-|hypothetical-protein
MTQRRLFFVHGAGGYVDDGPLAEALSAALGATLVMPVFSDDDMSIEAWARPVREHLAGLGADDLVVAHSFGATVLVHVLAEAAVSAPRPAVLLAMPNWGPDGWDVPQYAFTDTDADAPLPEGVALHHCVDDDVVPVEHLDLNTALLPSATVHRHPTGGHQFDGLAELIAADALGASALARGRSAPDPG
>NZ_CP016594.1|WP_033205227.1|5031200_5031794_-|TetR/AcrR-family-transcriptional-regulator
MSARKTARQVQAERSRTALLEAAAAAFVDAGVQAPVREIAARAGVGVGTVYRHFPTRADLVTAVYRHQVDECAALAEQLLAQQVPPRAALCRWTSAFTDFLVTKHGLSDALSSDDPSLVDLHALIFDTLVPAFASLLEPAQATGAVSADITALTFLRAIGNLCIVGPGYTDADARAMVGLLLIGSGASPAELENAGR
>NZ_CP016594.1|WP_004022394.1|5031890_5032796_+|hypothetical-protein
MSPESPTRQIVAVKPIPVPTSDRPFPLTVKVTAPVTGGHLPVIVFSHGNAWSMDGYAPLVDRWAASGFVVVQPTHLDSRHYGIGFDDPRFASIWRTRVDDAHAVIDHLDEILIAAGGDLRSRVAIDLLAAAGHSWGGQTVGTLLGARVIGPDGAVGPDLAHPAVRAGALIATAGTGDSLSEYAREHLPFMRPDFSTMSTPALVVAGGKDDSALSTRGPEWLTDAFHLSPGATDLMWIPDGEHTLGGIAGEAVRETTDEDPARVALVADAVADYLLDALGVSSAEWDSLGRADSAEYTLTHK

Crispr_ID: NZ_CP016594_12

• CRISPR_ID: NZ_CP016594_12
• CRISPR_location: 5595785-5595848
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016594_12

Consensus_repeat	Method
CGCTCCTCGCACCTCAGGGAGCA	CRISPRCasFinder

spacers of NZ_CP016594_12

>12.1|5595808|18|NZ_CP016594|CRISPRCasFinder
GAAGGCCGGGGTCGCTAG

CRISPR arrays and Neighbor proteins around NZ_CP016594_12

CRISPR arrays

The CRISPR arrays of NZ_CP016594_12

>merge|NZ_CP016594|12|5595785-5595848|CRISPRCasFinder
CGCTCCTCGCACCTCAGGGAGCAGAAGGCCGGGGTCGCTAGCGCTCCTCGCACCTCAGGGAGCA

>NZ_CP016594|12|11|5595785-5595848|CRISPRCasFinder
CGCTCCTCGCACCTCAGGGAGCA	GAAGGCCGGGGTCGCTAG
CGCTCCTCGCACCTCAGGGAGCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016594.1|WP_004021069.1|5591785_5592499_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016594.1|WP_004021056.1|5605803_5606187_-|ethanolamine-utilization-protein	unknown	unknown	gnl|CDD|380357
NZ_CP016594.1|WP_004021065.1|5595926_5596685_-|protein-glxC	unknown	unknown	gnl|CDD|223148
NZ_CP016594.1|WP_004021067.1|5593205_5594396_-|FAD-binding-oxidoreductase	unknown	unknown	gnl|CDD|223737
NZ_CP016594.1|WP_004021074.1|5585740_5586832_+|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl|CDD|213783
NZ_CP016594.1|WP_033204317.1|5600650_5601691_-|DUF3445-domain-containing-protein	unknown	unknown	gnl|CDD|378763
NZ_CP016594.1|WP_004021066.1|5594392_5595724_-|FMN-binding-glutamate-synthase-family-protein	unknown	unknown	gnl|CDD|239202
NZ_CP016594.1|WP_004021058.1|5604226_5605228_-|oxidoreductase	unknown	unknown	gnl|CDD|99782
NZ_CP016594.1|WP_004021068.1|5592508_5593201_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|380339
NZ_CP016594.1|WP_004021064.1|5596672_5597569_-|glutamine-amidotransferase	unknown	unknown	gnl|CDD|238888
NZ_CP016594.1|WP_081487003.1|5590602_5591739_+|Glu/Leu/Phe/Val-dehydrogenase	unknown	unknown	gnl|CDD|223411
NZ_CP016594.1|WP_004021071.1|5589227_5590610_+|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl|CDD|235798
NZ_CP016594.1|WP_004021063.1|5597635_5598991_-|type-III-glutamate--ammonia-ligase	unknown	unknown	gnl|CDD|274431
NZ_CP016594.1|WP_004021062.1|5599223_5600594_-|ammonium-transporter	unknown	unknown	gnl|CDD|223083
NZ_CP016594.1|WP_004021060.1|5601693_5602695_-|oxidoreductase	unknown	unknown	gnl|CDD|99782
NZ_CP016594.1|WP_004021073.1|5586828_5587818_+|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl|CDD|223101
NZ_CP016594.1|WP_004021072.1|5587834_5589196_+|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl|CDD|237001
NZ_CP016594.1|WP_033204191.1|5585102_5585597_-|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224439
NZ_CP016594.1|WP_004021059.1|5602691_5604230_-|DUF3445-domain-containing-protein	unknown	unknown	gnl|CDD|378763
NZ_CP016594.1|WP_004021057.1|5605224_5605794_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016594.1|WP_004021071.1|5589227_5590610_+|dihydrolipoyl-dehydrogenase	gnl|CDD|235798	PRK06416, PRK06416, dihydrolipoamide dehydrogenase; Reviewed.	0
NZ_CP016594.1|WP_004021056.1|5605803_5606187_-|ethanolamine-utilization-protein	gnl|CDD|380357	cd02228, cupin_EutQ, Clostridium difficile EutQ and related proteins, cupin domain. This family includes bacterial and fungal proteins homologous to ethanolamine utilization protein EutQ found in Clostridium difficile, as well as in other bacteria, including the enteric pathogens Salmonella enterica and Enterococcus faecalis. EutQ is encoded by the eutQ gene which is part of the eut (ethanolamine utilization) operon found to be essential during anoxic growth of S. enterica on ethanolamine and tetrathionate. In C. difficile, inability to utilize ethanolamine results in greater virulence and a shorter time to morbidity in the animal model, suggesting that, in contrast to other intestinal pathogens, the metabolism of ethanolamine can delay the onset of disease. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization. In contrast to the metal-binding catalytic cupins, the EutQ family does not possess the histidine residues that are responsible for metal coordination in the oxidoreductase and epimerase classes of cupins.	5.99668e-31
NZ_CP016594.1|WP_004021065.1|5595926_5596685_-|protein-glxC	gnl|CDD|223148	COG0070, GltB, Glutamate synthase domain 3 [Amino acid transport and metabolism].	1.51855e-37
NZ_CP016594.1|WP_004021064.1|5596672_5597569_-|glutamine-amidotransferase	gnl|CDD|238888	cd01907, GlxB, Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases including glucosamine-fructose 6-phosphate synthase (GLMS or GFAT), glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase), asparagine synthetase B (AsnB), beta lactam synthetase (beta-LS) and glutamate synthase (GltS). The GlxB fold is also somewhat similar to the Ntn (N-terminal nucleophile) hydrolase fold of the proteasomal alpha and beta subunits.	3.27486e-68
NZ_CP016594.1|WP_004021074.1|5585740_5586832_+|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl|CDD|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	2.06315e-165
NZ_CP016594.1|WP_033204317.1|5600650_5601691_-|DUF3445-domain-containing-protein	gnl|CDD|378763	pfam11927, DUF3445, Protein of unknown function (DUF3445). This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 264 to 418 amino acids in length. This protein has a conserved RLP sequence motif. This protein has two completely conserved R residues that may be functionally important.	5.40686e-60
NZ_CP016594.1|WP_004021066.1|5594392_5595724_-|FMN-binding-glutamate-synthase-family-protein	gnl|CDD|239202	cd02808, GltS_FMN, Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.	2.58451e-151
NZ_CP016594.1|WP_004021058.1|5604226_5605228_-|oxidoreductase	gnl|CDD|99782	cd06185, PDR_like, Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur [2Fe-2S] cluster domain. Although structurally homologous to FNR, PDR binds FMN rather than FAD in it's FNR-like domain. Electron transfer between pyrimidines and iron-sulfur clusters (Rieske center [2Fe-2S]) or heme groups is mediated by flavins in respiration, photosynthesis, and oxygenase systems. Type I dioxygenase systems, including the hydroxylate phthalate system, have 2 components, a monomeric reductase consisting of a flavin and a 2Fe-2S center and a multimeric oxygenase. In contrast to other Rieske dioxygenases the ferredoxin like domain is C-, not N-terminal.	7.86352e-78
NZ_CP016594.1|WP_004021068.1|5592508_5593201_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	2.69298e-13
NZ_CP016594.1|WP_004021067.1|5593205_5594396_-|FAD-binding-oxidoreductase	gnl|CDD|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	1.4108e-57
NZ_CP016594.1|WP_081487003.1|5590602_5591739_+|Glu/Leu/Phe/Val-dehydrogenase	gnl|CDD|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	1.01421e-79
NZ_CP016594.1|WP_004021072.1|5587834_5589196_+|2-oxo-acid-dehydrogenase-subunit-E2	gnl|CDD|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	4.3934e-155
NZ_CP016594.1|WP_004021063.1|5597635_5598991_-|type-III-glutamate--ammonia-ligase	gnl|CDD|274431	TIGR03105, gln_synth_III, glutamine synthetase, type III. This family consists of the type III isozyme of glutamine synthetase, originally described in Rhizobium meliloti, where types I and II also occur.	0
NZ_CP016594.1|WP_004021062.1|5599223_5600594_-|ammonium-transporter	gnl|CDD|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	1.77524e-122
NZ_CP016594.1|WP_004021060.1|5601693_5602695_-|oxidoreductase	gnl|CDD|99782	cd06185, PDR_like, Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur [2Fe-2S] cluster domain. Although structurally homologous to FNR, PDR binds FMN rather than FAD in it's FNR-like domain. Electron transfer between pyrimidines and iron-sulfur clusters (Rieske center [2Fe-2S]) or heme groups is mediated by flavins in respiration, photosynthesis, and oxygenase systems. Type I dioxygenase systems, including the hydroxylate phthalate system, have 2 components, a monomeric reductase consisting of a flavin and a 2Fe-2S center and a multimeric oxygenase. In contrast to other Rieske dioxygenases the ferredoxin like domain is C-, not N-terminal.	6.36244e-58
NZ_CP016594.1|WP_004021073.1|5586828_5587818_+|alpha-ketoacid-dehydrogenase-subunit-beta	gnl|CDD|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	2.01064e-152
NZ_CP016594.1|WP_033204191.1|5585102_5585597_-|Lrp/AsnC-family-transcriptional-regulator	gnl|CDD|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	4.13649e-21
NZ_CP016594.1|WP_004021059.1|5602691_5604230_-|DUF3445-domain-containing-protein	gnl|CDD|378763	pfam11927, DUF3445, Protein of unknown function (DUF3445). This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 264 to 418 amino acids in length. This protein has a conserved RLP sequence motif. This protein has two completely conserved R residues that may be functionally important.	2.24964e-74

Protein sequences

>NZ_CP016594.1|WP_004021066.1|5594392_5595724_-|FMN-binding-glutamate-synthase-family-protein
MTNNLSTEQRGLRESATFDRTTIAAIQRAAETGIYDIRGWGAKRKLPHFDDLLFLGASMSRYPLEGYRERCDTDVVLGSRNAKYPLHLSTPVTIAGMSFGALSAGAKEALGRGASEVGTSTTTGDGGMTPEERGQSKNLVYQYLPSRYGMNPDDLRKADAIEIVLGQGAKPGGGGMLLGQKISERVAGMRTLPQGIDQRSACRHPDWTGPDDLAIKINELREITDWEKPIYVKVGATRTYYDVKLAVHSGADVVVVDGMQGGTAATQDVFIEHVGIPTLAAIPQAVQALQELGVHREVQLVVSGGIRNGADVAKAMALGADAVAIGTAALIALGDNDPRYSAEYEALGSAAGFYDDFQDGRDPAGISTQDPELSARFDPVLGGKRLANFLRVMTMEAQTIARACGKAHLQHLEPEDLVAISIEASAMARVPLAGTNWIPGAGL
>NZ_CP016594.1|WP_004021067.1|5593205_5594396_-|FAD-binding-oxidoreductase
MSTETASVVIVGGGLEGVAAAWALGQRGITDVIVCERDTVGGGMTGKSSGIVRCHYGVGSLAAMAAYGLEVFEKAEEIFSADIGFRQTGYVVGVGEPNVESMRASLAAQRAVGVQTEEIDAADVAAMWPTADLDPFAAFGWEERGGYGDAYQTAQAFAASARATGIRIRQGTNVTGLVVDSDRVTGVRLADGSTISADTVVVATGVWTKPFLAPFGIDVPIEVHREQIVMIHPGDDLGDVPVFSDLVSLQYVRPDVRGEILFGNSDLAALDIADPDGYRNRADSDFIDLTVEKVGTRFPGFSDPAITTSYAGCYDVTPDWNPIISRGPLDGLVLAAGFSGHGFKISPAVGRLIADLVVDGRSSDPRVPETDFRFSRFDDGDLLKTRFPYVGAGEMR
>NZ_CP016594.1|WP_004021068.1|5592508_5593201_-|helix-turn-helix-transcriptional-regulator
MCQLSGNVVSLYAGSVTDDPLIRNQSGIARERPVDQSVEELELETAIAHNVRRLRRQQGLSVGDMATRVGISKAMLSKIENAQTSCSLSTLARLANGFDVSVTSLFRGAEMERSAVFVKAGEGSEIVREGSREGHEYELLGSLRGEHKRLECLLVTLTEKSVTQPLFQHAGTEFLYVLEGVMDYAHSRSVYRMHPGDSLQLDGEGAHGPVELIELPVRFLSVIAFPDSAV
>NZ_CP016594.1|WP_004021069.1|5591785_5592499_+|hypothetical-protein
MTAAGTVRGVTDSKVIVAIRGDGTSRTAADDLVERCAAAGATRVQVNLSDDAVSGAMRIDELDPPIVAVLSFWARGPGPVLAAVDAAIDGPIAAWEVTARAPLDPDLPADGTRIDALSNVAFLRRPDELDHAEWLRRWLDDHTQVAINTQATFGYVQNIVERPLTEDTPPVAAIVEELFPMAAVSDIHAFYGSGGDQQELERRMTLMLESVSRFGADRHLDVMPTSRYDFDLSRSRT
>NZ_CP016594.1|WP_081487003.1|5590602_5591739_+|Glu/Leu/Phe/Val-dehydrogenase
MADTHSHSIEEGITLSVTVDTRHDAHDAAVFGRADAIPGLPHEQVVFCEDAATGLRAIIGIHSTALGPALGGTRFHAYPDQGAALTDVLRLSRGMTYKAAVAGVDLGGGKAVIIGDPARDKTPELLRAYGRFIDTLGGRYISAGDVGTGTDDLDIIGETTEHVVGRSTSAGGSGNSGPMTAFGVYQGMRAAAAAAWGAPSLADRVVGVEGVGKVGAELISLLLADGARVVATDVNHTALASVANRFTEISTTGDLLGEALDVYAPCALGGTLHPLSLERMTASVVCGAANNQLLEPGVDEQLRDRGITWVPDFVANAGGLIQVAGEREGIEPDVVRSRVATIYGTVTGIFERAAAESIAPGRAADRIAQTRLAEARSV
>NZ_CP016594.1|WP_004021071.1|5589227_5590610_+|dihydrolipoyl-dehydrogenase
MTRTPDVVVLGGGSGGYACAIRAAQLGLAVTLIESDKVGGTCLHRGCIPTKALVHAGEVAETIRDSSRFGVLGSLDGVDMERVHSYKNGVVGKLFKGLQGLVRHHGIEVISGLGRYMGNRTVDVDGELIEARRAVVLATGSQPRTIPGLPIGDRIMTSDDALELSELPSRAVVLGGGVIGVEFAGLLDSLGTEVTVVEALPRLVASEDEWSSKKLARAFRKRGIDVRTSTKVLDAQQSGGTVTISTDSGEQIEADLLLVAVGREPRTADSGVAEAGIALDRGHVVVDNQLRTNHDGVWAVGDVVAGLQLAHRGFQQGLYVAEQIAGRQPSPRDETGIPRVTYTSPEIASVGLTEAQARAKYGDVTTAEYDLGGNGKSQILGAAGGIKLIREGTRQGGGPVVGIHMVGDRISELVGQAQLIVNWNAHPEDVAALIHAHPTQSEALGEAHLALAGQPLHAHG
>NZ_CP016594.1|WP_004021072.1|5587834_5589196_+|2-oxo-acid-dehydrogenase-subunit-E2
MSTVNTFHLPDLGEGLTEADLVTWMVAVGDTVELNQVIAEVETAKASVELPSPYAGTVVALHAAEGDTIDVGRPIIDIDTGGGPVDRSDVPAETAAAASDGETERVPVLVGYGVAGEGTSRRRRTGTTPRVDDAPADGTVTLGITPAVSEGRRRPLAKPPVRFLAKQNGVDLTAVTPTGRHGEVTRADVTGYLSDRAAPSGDGAHVAADVVAESAPATRHLEETRTPIKGVRKHTAAAMVTSAFTAPHVTEFMTIDITETLDLLERLRVHRRFAETRLTPLALISKALLIALRANPSLNSYWDEDAQEIVTKHYVNLGIAAATPRGLMVPNIKAAERMSLHELASALVELTTTAKSGKTPPADLAGGTITITNVGVFGVDSGTPILNPGEAAILCVGAIRRQPWEHHGEIALRSITTLSLSFDHRLVDGEQGSRFLADIGRILSDPLELIALG
>NZ_CP016594.1|WP_004021073.1|5586828_5587818_+|alpha-ketoacid-dehydrogenase-subunit-beta
MTDTTTLPLGKALNAGLRRALEDDPRVLLMGEDIGALGGVFRITDGLQKDFGPHRVVDTPLAESGILGTAVGLAMRGYRPVIEIQFDGFIYPAFDQIVSQVAKLHYRTSGNVRMPLTIRVPYGGGIGAIEHHSESPEGYFAQTAGLRVVTCSTSADAHLMIRQAIASDDPVLFFEPKRRYWEKGEVDLQAPVDSYPLHRARTVVEGDDITLLTYGPLVTTARQAAKVAAEEGTSVEVIDLRSLSPLDMDTIENSVRKTGRLVVAHEAPVFLGIGAEIAARVTERCFYHLEAPVLRVGGFAIPYPPAKLEEHFLPDVDRMLDAVDRSTAA
>NZ_CP016594.1|WP_004021074.1|5585740_5586832_+|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MVFELHAVPAQLITEDGIRVEDDDLSPAVADIDGEALQGLYEDLVVVRRIDSEATALQRQGELGLWAPLLGQEAAQVGSARALDTSDFVFASYREHGVAYCRDVDPTHMLRFWRGSTHSGWNPLEYRMTTPAIIVGCQALHATGYAMGSALDGDTAATITYFGDGATSQGDISEAFLFAASFRAPVVFFCQNNQWAISEPVSLQTAVSIAERGRGFGIPSIRVDGNDVLAVLAATRLALANAREGNGPSLIEAVTYRMGPHTTSDDPTRYRDAALDDEWKQKDPLDRVRTLLEREGLVDDAFLARIQERADTTAAALRKGCLETVEPEPMSLFDHVYADPHPLIDDERAQFATYLAGFEGSTR
>NZ_CP016594.1|WP_033204191.1|5585102_5585597_-|Lrp/AsnC-family-transcriptional-regulator
MPDLDRTDARLLLALCETPRATGVDLASRLDVSRNTVQSRLDRWDRDDVLAGYDRRVSPRSLGLPLLAFVITTVDQRRLAEVTDSLVGIPEIVEAIGLSGPSDLLIRIVAADTDDLYRVAGLILDVDGVERTNVSLAMQELVPYRTHQLLRRAATGESPVKGAR
>NZ_CP016594.1|WP_004021065.1|5595926_5596685_-|protein-glxC
MDTMTADMASTTSVPASTDTAKAETMSTNHTFDLASTALREVNSTLHGDISGEIVIDNPAGAHSVAAGVNLPLKITINGHVGYYAAGMNQQAEVTINGNAGTGVAENMMSGSVIVKGNASQSAGATAHGGLLVVEGDAAARCGISMKGVDIVVGGNVGHNSAFMAQAGRLVVRGDAGDGLGDSIYETRIYVRGEVASLGADCIAKPMRAEHLDELTGLLKAAGFGDDDPRDYTRYGSARELYHFKIDNTSAY
>NZ_CP016594.1|WP_004021064.1|5596672_5597569_-|glutamine-amidotransferase
MCGIVGLHLRNPDLHPRLGEMLAEMLGEMQDRGADSAGIAVYGNPAWAPPGHGCISLLELDAVPDEVSAILSAALGVPVAAQSIDITLVASAPVTSDELLAAARAAYPHALVAGFGSDLTVLKGVGAPRDLTESWGLAAVSGWQGVGHTRMATESAVTSSGAHPFAVGPEQCLVHNGSFANHATIRRELRAAGVEFDSENDTEVGARFVAHQLAAGKDVETALKEVCANFDGFYTLLVSNRDSFAVVRDAIACKPAVIAETDDWVAMASEYRALAKLPGVENARIWEPEPEVVYAWTR
>NZ_CP016594.1|WP_004021063.1|5597635_5598991_-|type-III-glutamate--ammonia-ligase
MTTTETTTGDLADLCATHGTKFILAMFVDLRGKPCAKLVPVEAVDELASDGVGFAGYAVGAIGQEPKDPDLIAIPDVRSFLPIPFIKEGLAVVQCDPHVEGKPWPFAPRNILKALIAQTADAGFEPWVGAEVEYFLLKRAADGSLMTADAADDSDQPCYDVRGLTRMYDHLTTVSTAMNQLGWRNYANDHEDGNGQFEQNFAYSDALTTADRVVTLRYLLSALAAEKGMIATFMPKPFAERTGSGLHFHLSLTQAGDAVFPQVTDDERGLGLSETAYGFIGGILEHAPALQAVIAPTVNSYKRTGATATRSGASWAPRRATYGGNDRTHYIRVPDDQRVELRGGDGSANPYLAAAALLGAGLDGIKRSLDPGAVGNCPGHIAELPLTLLHAVEALEADAVVTGTLDAALPEDWPADQQRVSAYFAGLKRDEFFDWHAAVTPWEVDKYLTAF
>NZ_CP016594.1|WP_004021062.1|5599223_5600594_-|ammonium-transporter
MEPILAANADLAWMLAAFVFVLLMFPGLAFFYGGMVGSKNVLNIMTMVMSTLAITAVLYVVIGHGLVSGPSVGGWGLIGNPTDYIGLTNWLTDDASGATQTLYFAAWFILFAAITIAIVASGAAGRMKFSAWLVFAPIWLVVVYFPVAHWVFAADVDDNYSGGFLLNDLEIVDYAGGTAVHMNAGVAALALAVVLGARKRRMERPHNVPMTIMGGGILFFGWFGFNGSCALGANFLAQAVILNTLLAGSAGMIGFAIIERWREGHVTSLGMITGTVAGLVGITPAASSMAPLGALLVGIFAAAVVAFLLSFKSKIKIDETLDAFAVHGIGGIVGTICIVLFATEAAPAGVQGILFGGPVDIVWRELAGIVITCTYSFVMTWLIAKGLDKLIGMRVDEETEMVGLDTAVHAETAYEIPAASVGHAGGLATMSPARAADKVEEAMPPSAPASAPPAGV
>NZ_CP016594.1|WP_033204317.1|5600650_5601691_-|DUF3445-domain-containing-protein
MDSFSTRRRERSERAECDRRVDHLANLPWPFPDELEEFSYSVNVEPARIPRPTRAGEWGRHLVDLGGVEYPAIMAERRRILDADPTRVRVRPGMELACWDLLLYYLRDLGHAYPANMRLTEYGDGRFHWRNDLLGTDQGFVLGDPATLPWGPMEFLAREVPDDLLLVTERDGHLYFDAGVVTFAAAWSVSFDVGMDMYEIHAPVPRMLREGIVARAEQFLRRLPADQVYRRVNWTLSASDSHKLDVSLEELPEWAADVAGMIADGDFGRARLRIELEHFVRLPMSGAVTFNIRTFMASLEDVKRIPEWAGQLATVIETLGEDIAAYKGFLDYRDNVVAYLRGQSRP
>NZ_CP016594.1|WP_004021060.1|5601693_5602695_-|oxidoreductase
MTAATVGVAYPAHLHPAYATGPRPMRVLSVRRLTHEVTHFRFGPLDADAPALTAYQPGSHLIISAGGQRNAYSLVDDGMYPTSYGISVLRRGAGGGSDWLHDNLVVDAVIEIEGPRSMFPPVLDQRGALLVAGGIGVTPVLSHARALARDGRRVDIVYSYRPGCDAHADDLRALAEQPSVTLHEVSGAAATAALLAERLRAQPLGTHAYACGPASMLTAYTELAEAAGWPSTRVHLERFSAPEQDPGDPFTVTLASTGVRIDVPPGVSLLQRLLDNGAPVSNLCRQGVCGECRIPVRGGRIEHRDFVLTDDEKATGDAMLCCVSRGVEIEVDL
>NZ_CP016594.1|WP_004021059.1|5602691_5604230_-|DUF3445-domain-containing-protein
MTTTFEPTAGTGVPSADDLLAGFPFPFPEDRYRYSTNVEPARTTVTTAAGRWGAAVVDIDSEYRAELDRRAMILAADPTRHAVLPHMVPAAWDAMLTLMRELDATHPDQMQLRTTGTDTWSWRNEILGIEQHFRYGDPASLPEEPLRYITSQVQEDIALLDQRNDQLYVDAGVVTFAADWSFGFDVGMSFLEIHGPVPRIRKEGVITRAHEFLKRLQPHQPYRRTNWTLTIDRRLDVSTEIYHEWGPDREAIQRVPDDEFGRRVHLRVEVQHLIRLPDSGAVMFLIRTYMLPLDQLATVEPWRRRAADVLSELPADMADYKGIIKFRERAAEWLRAWTPASTATAGPGMPVWPTRPPAVDTTGSAFVVVAIGDDADVAHVSRGWVGEAEAIGATRLLVLDALVDAADRSALRSALDECRTGTRILVTGGQYDVMTALAMARAAGAVAAELSSYVTHTRDLPLYCAHCRDTFRVVAAAGGTVVCPGCARDLGVHEHHSPVLGSFLGSASGGEA
>NZ_CP016594.1|WP_004021058.1|5604226_5605228_-|oxidoreductase
MISGVAEMSPSEPVLRRASAATTLELVVTAVDAPSRDIRTITLADPSGRALPAYVPGSHLVVHAGASTNAYSLTGDGAHPSQYSISVLRLPGGKGGSRWLHDELEVGATVTVGLPRSAFAPIARARKHLLIAGGIGITPMVSHLRAAVRWRRDVQLLYVFRDSSAAHLDDVTRLAGRRAELFTDRASFTDRLGQALRAQPVGTHLYVCGPSSMIDAVVGAAVDAGWPESRVHFERFGVDALDPGDPFRVELTASGRTVDVPAGTSMLEALEDEGIAVPNLCRQGVCGECRIPLAGGSPVHRDLYLSTEEKDAGDAIMPCVSRATAAGTLEVPL
>NZ_CP016594.1|WP_004021057.1|5605224_5605794_-|hypothetical-protein
MSQIAFSSVPAWARPGGPIEATSPVPTGSSYVLVGVGDVAETLARWESALPPQVTTRIHGDTDTAAAQLGSALTEAVVGVRVWIAADAGSALTLRAVALGAGLEDDEITVVPAASAAEVTVEVFCAHCRSVTRTAAAIDDVVACAGCRRDLLVYHHVSRRTGHYLGFMIDAETAQSPCPANEPHEEPVS
>NZ_CP016594.1|WP_004021056.1|5605803_5606187_-|ethanolamine-utilization-protein
MTIESAKALEFRVTSGGHEDLPKMPEAEYPGTEGFIGDVYENPDGSPMCSGYFELRHTDEPLYYEYEYDEMKVVLEGEFLLENKETGQKTVAKAKDAIFFPKGSKIYFSTPAYALAFYTGLRDATLL

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP016594_9	9.2|3958643|29|NZ_CP016594|PILER-CR	3958643-3958671	29	MH834627	Arthrobacter phage Ryan, complete genome	7359-7387	5	0.828
NZ_CP016594_11	11.1|5022214|32|NZ_CP016594|CRISPRCasFinder	5022214-5022245	32	NC_047751	Ralstonia phage phiITL-1, complete genome	24152-24183	5	0.844
NZ_CP016594_9	9.2|3958643|29|NZ_CP016594|PILER-CR	3958643-3958671	29	NZ_CP012185	Pseudonocardia sp. EC080619-01 plasmid pBCI1-2, complete sequence	372208-372236	7	0.759
NZ_CP016594_9	9.2|3958643|29|NZ_CP016594|PILER-CR	3958643-3958671	29	NZ_CP012182	Pseudonocardia sp. EC080610-09 plasmid pBCI2-1, complete sequence	675202-675230	7	0.759
NZ_CP016594_9	9.2|3958643|29|NZ_CP016594|PILER-CR	3958643-3958671	29	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	414461-414489	8	0.724

1. spacer 9.2|3958643|29|NZ_CP016594|PILER-CR matches to MH834627 (Arthrobacter phage Ryan, complete genome) position: , mismatch: 5, identity: 0.828

actgggccgagggcctggggccacacgcc	CRISPR spacer
gtcaggccgagggcctggggccactcgcc	Protospacer
....******************** ****

2. spacer 11.1|5022214|32|NZ_CP016594|CRISPRCasFinder matches to NC_047751 (Ralstonia phage phiITL-1, complete genome) position: , mismatch: 5, identity: 0.844

gcaagcgccacccccaactgatcgagcgagcg-	CRISPR spacer
acaaccgccaccccgaactgatcg-gccagcgc	Protospacer
.*** ********* ********* ** **** 

3. spacer 9.2|3958643|29|NZ_CP016594|PILER-CR matches to NZ_CP012185 (Pseudonocardia sp. EC080619-01 plasmid pBCI1-2, complete sequence) position: , mismatch: 7, identity: 0.759

actgggccgagggcctggggccacacgcc	CRISPR spacer
gcctggaccagggcctggggccacacggt	Protospacer
.*. ** * ****************** .

4. spacer 9.2|3958643|29|NZ_CP016594|PILER-CR matches to NZ_CP012182 (Pseudonocardia sp. EC080610-09 plasmid pBCI2-1, complete sequence) position: , mismatch: 7, identity: 0.759

actgggccgagggcctggggccacacgcc	CRISPR spacer
gcctggaccagggcctggggccacacggt	Protospacer
.*. ** * ****************** .

5. spacer 9.2|3958643|29|NZ_CP016594|PILER-CR matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 8, identity: 0.724

actgggccgagggcctggggccacacgcc	CRISPR spacer
gggaggacgggggcctggggccacacgat	Protospacer
.  .** **.***************** .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	75574 : 168115	81	Gordonia_phage(35.71%)	transposase,integrase	attL 121026:121085|attR 129092:130469
DBSCAN-SWA_2	3761556 : 3770607	7	Gordonia_phage(33.33%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP016594|75574:168115|DBSCAN-SWA
GCTAGTGTTCTGAGTCATTAATTCGTGTGCAGTAGTGGGCGATGGAGTCGAGGATCTGGTCAGCGGTCTTGACCCACACGTAGGGGCGGGGGTTGTCGTTCCAGGTCTCGATCCATGCTCTGATGTCGGCGTTGAGCGCTCTCACGGTGCGGTGGGGGGAGCGTTGGAGCTTCTTGGTGGTCAGTTCGGCGAACCAGCGTTCGACGAGGTTCATCCAGGATGAGCTCGTCGGGGTGAAGTGGACAACGAATCGTGGGTGCGAGGTCAGCCATCGTTTGACCGCGGGCGTCTTGTGGGTAGAGGCGTTGTCCATGACCAGGTGGACGTCGAGCTCGTCGGGCACCTCGGCGTCGATCTTGCGGAGAAACCCGATGAATTCTGTTGCCCGATGCCGTGAGTGAAGCGAACCGATCACTTTTCCCGACGCGATGTCCAACGCCGCGTACAGACTGGAGGTGCCGTTGCGCACATAGTCGTGGCTGGCCCGTTGCGGGGTGCCCGGGAGCATGGGAAAGATCGGCTGGGTGCGATCGAGAGCTTGGATCTGGGTCTTCTCGTCAACGCAAAGCACCAGGGCACGTTCGGGTGGGTTCATATAGAGCCCGACGACATCGCGGACCTTCTCGGTGAACAAGGGATCTCTCGACAGCTTCCACGAATCCTGTTTGTGCGGAGCCAATCCGAACGCCCGCCACACACGCGACACGGTTGACTGTGACATGTCGAGATGCTCGGCCATCGCCCGCGTCGACCAGTGTGTCGCATTCTTCGGAGTGGTCTCGAGAGTCGCGGTGATCAAGTTTTTGATCTGCTCGTCGTCGACGGTGCGAGGTCGCCCAGGCCGGGGTTCGTCGAGCAACCCCTCGCAGCGGTGCTCGACGAACCGGCCTCGCCAGCGCCGCACGGTACTGCGATTGAGGCCGAGTCGTTGTGCCACTTCAGTATTCGAACCGCCATCAGCGGCGGCGAGAACGATTCGTGAGCGCATCGCCAAACCCGAGGCCGTCGTTCGCCGACGCGCCCACCCTTCGAGCTCACGGCGCTCGTCATCAGTCAGAACAATATCCACTGCTCGCGGACCCCGGGTTGCCATTCCCTAGCCTAACAACCGAACGGAAATTAATGACTCAGGACACTAGGTGGGGTTCGCCGCGCTACATTCCAGTGATGACCGCACTTGAGCGCGGTCTTCCCGTTACGGCAACGTCGAACACACTCGTGAGCTGTCGTGGCTGAATCTATTGGCGATGGGCGGTTCGAGGCCGGGCTCGAGCACCTGCACCGCTACGTCGCGGTGTACGGCACCAGCAACGCCCGCCGGCGCGATGTCATTGACGGATTCGCGATCGGCACCTGGGTGCAGAGCCGCAGCGCTGACTACCGCAAGGGCCGGTTGTCGGCCGAGCGGATCGAACGGCTCGAGACCGAGTTCCCGGACTGGCGGTGGACCATCCGGACTAATCAGGGATGCGTCAATGCATCGCGACCGTAAGATGGCGAGCAGCCACCGCTCACGGAAGCGGAGCTTGAGAAACTGTTCCTCGCACTGGCCTAAACAGTCGGCCAACCTAGTACTACCGCGAGTCGTAGCGACTTGAATCGCCCCGGGTTTGCTGGAGGCTCGGTTAGTTGGTTCCAGCGTTTGCGGGGACCGGGTTCTCACGGTAGCTGGTGACGGTTTGGGTCGACCAGTAGGCGCTCTCGTACTCGACGGGTGGGACGTGTCCGATCTCGCCGTGCAGGCGGCGGTGGTTGAACCATTCGACGTACTCAGCGACGGCGATCTCGACCTCGCCCACACCTGCCCAGCCGCCTCGCGGGCGCATCACGGGGTTACGGATGCATTCGGCTTTGAACAGCGAGTTGAACGCCTCAGCCATCGCGTTGTCGTATGAATCCCCTTTGGAGCCAACAGATGTCACCGCTTCGGCTTCGGCCAGTCGTTCGGTGTAGCGGATGGCTCGGTATTGCACTCCGCGGTCGGAGTGGTGGATCAGCCCGGCCACGTCGTGGCCGGCACGCGACCGTGCCCACAATCCCATGTTCAGGGCGTCGAGGGCGAGGTCGGTGTGCATGGTGGTCGAGACCTGCCAGCCGACGACCATCCGCGAGAACACGTCCAGGACGAACGCCGCGTACACCCAGCCCGAGTGGGTGCGGATGTAGGTCAGGTCCGCCACCCACAACGCGTTCGGTGCCGCCGCGGTGAACTGACGGTTGACCCGGTCAGCCGGCCGGGGTGTTTCAGCTCCCTCGCTGCGCGTGGTCTTGCGTGTCTTGAGTCTCGCTATCCCTTGCAGCCCATCGGCTTTCATCAATCGCTCGACGGTGCAGCGGGCAGCACTATGGCCCTGTCTGCGCAATTGGGCATGCACCTTGCGGGCACCGTAGACGCCGAGGTTGTCGGCATGCACCGCGCGGACCTGGGTAAGGAGCTCCCGGTCACGCACCACACGAGGCGCCTCGGTCTTCTGGGGGCTCAGGTGGGCTCGTACCGTGGACGGAGCGATCTGGGCGGACGTATCGCGCAATGCCGCACAGATCGGATCGACTCCGTGTTCATCGCGGTGAGCCGCGACGAACTCCACGATCAGCGCTGTGGGCGGTCGATCTCCGCCGCAAAGAAAGCCGAAGCCTGCTTCAAGATCGTGTTCGCTCGCCGCAGTTCACGGTTCTCCCGCTCCAACGCCGCGATGCGGTCAGCGTCCTCACTCGTGGTGCCCGGGCGGACCCCGCCGTCGATCTCGGCCTGACGAACCCAATTGCGCAACGCCTCGGGATGGACTCCGAGCTGATCGGCGATCCGCTTGATCGCACCTCTCGACGAATCGGGATCTCGTCGCGCTTCACATGCCATCCGGGTGGCCCGGTCCTTGAGTTCCTCACTGTACTTGCGTGGTGCTGCCATGCTCTCCATCCTTCACAGGTTCGAGAGCCTCCGACAGACCCGGGGCGGTTCAACTGTAGCCAGGACGGAAGGAAGAGAGCTGCACATTCGAGGGAGCTCGCCGCCCTCCCCTCCAATCCTGTGAGAACAGTGCTGCCGGTGACCGTTATGGTTCAGCCGCTGTGTACGAGCCTGATGCTGCAGCGCCGCGACTGGTGGGCGGGCAATCCGCTCGGCCTGACCCTCGCGGTCAAGCCGGTCCTTGCGGTGTTGTTTTCCTGTCGCTACTGAACCGGCAGTGGAAGGCCGAGCGTTTGCAGTTCCAGCCCTGTTGACCGTCGCAGCCTGACCGCTGGCGGTGGATCGCCGAACGTGGTCGCGTACCTCGCAGAGTTGGCGGCGCGCAGAACGGAGACGCGTGCGGCGTCAGTCTGACCGCGTGAAGTTGGCGAAGAAGTCATCGATTGTTGATACGTCGGCATAACGTCGAAAGTGAGCAACGTCGACCTTGACGAAAACACCGCTAGAGGTGAAGTACGTTTGCTCATCGAACGATCCGGCGGCCGCGATGTGCAGTAGGCGATCCGACTCGTGGTCAATCCAGGCAGTGAGACGTATGGGAGTGTGCAGCGGGACCGGCCGGCGGTATTCGACGGTCAGGGTGCGGGTCACCGCGGGGGTCCGCGCGATCCACAGGGTGAAACCCATGATGTCGTCGCAGGCGGCCGAGATCGCGCCACCGTGCGCCAACCCGGGCGCGCCGAGGTGTTTCTCGTCGAAGGTGTGATCGGCGTACACCCGCTCGCCGCTCCGGTAGACCTCAAGTTGAAGTCCGTGGGGGTTGCTGCTTCCGCAGCCCATGCACTGGGACGAGTGTGCCGGCAGTCTTGCTTCGGGGGTCATCTCTGATCGTTGTCCTTAACTCAGCCCGCCACCTACGCAACAGGGTGCGGGGGGATCGATGAGGTGTGGGAACCGGTCCCGAACACGGTCTGTGCTCACCACTATAGGTAATACTGCCAGTACCTGATACTGTCCATTACGCACACGCGAATGGAGTGGCGCACACCACGCGCACTAGGGGGGGAGATGGCCATCACCACCGGCACAGGCGTCAACCGTCTGCTAGACGGCGCTGCCACTTTTGGTAACACCGTCGGCTTGGCTGGTCAGGCCCTGCGGTGGGTAGCAGTAGACATTGCTACAGGACGATTTCCGTTTCGCGAAGCCGTATCGCAGACCTGGTTCGTCATCGTCGTGACAACTCTGCCGGCGATTCTCGTAGCTGTGCCATTCGGTGTCATCGTGTCAGTACAGGTGGGTAGCCTCACTCAGCAAGTTGGGGCCACGTCAATAGCTGGCGCCGCTGGTGGCCTCGGGATTATTCAACAGGGAGCGCCCATCGTTACCGCCCTCCTACTCGGGGGCGCGGCCGGATCAGCGATTGCCTCTGATTTGGGTGCTCGAACGATTCGCGAAGAAATTGCTGCCATGGAGACACTCGGACTCAATCCGATCAGGCGAGTCGTAGCGCCCCGGTTCGTATCTGTGTTGATCACCGCGCCGCTGCTCTGCATGCTAATCGTCTTCACCGGGCTGCTGGCGGGCTACGCCATCAGCGTCGACGTCCAAGGCATCACACCAGGCAGCTACGTCGCCTCGTTCGCTTCGTTCGCATCGATAACAGACATCGTTGTCGCTCTATGCAAATCGCTTGTGTTCGGACTTGTAGTGGTGACGATTGCTTGTCACCGCGGCCTGTCGACGAAAGGCGGCCCTAAAGGCGTCGCAACCTCAGTAAATGCCACCGTAGTACTGGGCGTCGTCGCATGCTTCGTGATCAATGTCTTTATCACGCAATTAACAACCATGTTCGTCCCCCAAACTATTGGATGAGAAACGCCTCGTGACCACCGTTCCCTCCCGGAGGTTCTCCGCCGCCACCCGCCCTGTCGAAGCCGTGATCGCGCCAGTTGTACACGTACCTGAACGCTTGGGGCACGTCGCGACCTTTGTGATCGCCGCGGTCCTCGGCATCCGCCATGTGATCACCACCTACCGACGCCAAACCCTGCTCTACATACAAGAATTCGCCTGGGGTAGAGGTGCAGTCTTGGTCGGTGGTGGAACGGCCATCGTCCTCGCCATCCTCGGCATCGCCGTCGGCGCCTCAATCGGTATCCAGGGTTACGCCTCTCTGGACCTCGTAGGGATGGGTTCACTGACGGGGTTCATCTCTTCCTATGCCAACACCCGAGAGCTTGCGCCAATGATCGCGGCGATCGGGTTCGCAGCACAAGCCGGCTGCCGGTTGACAGCTGAGATCGGCTCGATGCGCATTTCCGAGGAGATCGACGCTCTCGAGGCTATGGCGGTACGTCCTATTCCATTCGTCGTCAGCACTCGCGTAGTTGCGTCGATCACGACCGTGATTCCTTTGTACATCGTCGCGCTTATTCTCGGATTCGGGGCCGCCAAACTCGTCGTCACACAAGTTCACGGCCAATCCGGCGGCACTTACGATTTCTATTTCGACCAGTTCCTCAAACCTCAGGATCTTGCCTTCTCGCTTATCAAAGTTCTTGTATTTGTCATTTCTGTAGTGATTATCCATAGCTATCAGGGCTACTTCGCCACAGGCGGAGCTGAGGGGGTGGGTCGAGCGTCCGGTCGAGCGATCCGCACGAGCCTCATAGTCATCGTCGTGGAGGACATGATCTTGACCCTTCTGATGTGGGGATTCGATTCCGGCGTACGGATTTCAGGGTAGGGGGTTCAGTGGCTGTCTTTCATGATCCGTCCGGACGCGAGCCGTCGCACGGGAACCTGGCCCTTCGGGGGGTCGCCCTATTGATCCTCGGCGCGATAGCTGCCTACTTACTGATAAGTGACGCTAACGGCGACTTCAGCGATCACACGTCGTTGACCATCAACACCGACGCGATAGGCGACGGATTGAAGGGGGGATCGGATGTGAAGTACCTTGGGTTCACCGTGGGGGAGGTCTCGAGCATCGCGGTTCGAGACCGTGGCGCGGCGGTCAAAATCAACCTCACCGGTTCCGGTAACGACCTAGTTCTCCGGCAGGGCATGACGGTGAACTACACCTCGTCAAACGCATTGGGACCAACTGCACTGGAGATCGTAGATCCTGGACAAGGACCACCCATCGGTTCCGGCGGGAGTGTCTACGTGAGCAGGTTGCAATCTGAACAGACCTCGGTGTCAACGCTTGTTCGCAAGATCTCCACGCTGGTCGAGGCACTGGACCAGCCCTCATTTGAAGCGGTAGTGAGGTTCATCGTTGAGGACTCGCAGGCAATGGCTGATAGCGGAAGACTCGTTCTCCAGATTGCGCAACTCACGCGAGATGTCCAGAAACGGCCGGTCGGGGAGGACCTAGGAATTGCGGCTAACCTGTCCACCGGAGTCGCCGACTTCATGACGCCGTTTGTCCCTGGCGTCTTGAAGAACGTCGATATCGCTGACTTTTTCGCCACCCAACAAAACATCGACCGCACGAAGAGTAATCTCGGCGACACGGGAAAGGTTCTTTTCGGTGGGCTCGGCGGCCTGCTCGATAAGAATTACCCAGCCCTGAGTTCGCTGTTAGACGTCGGCCTTGACCTAGCGCGGCCCGTCGCCAGATCCGCCTCGGGGCTAGTTCGCACGGTGTACACGATCCCGCAGATCCTCGATGGCATCGACAAAGCCTTGCCGAAATTCAACGAACGGGTCCAGCTCCAGCTAGCACTGGTGGTCCAGACGTCGCCTGCCCTACAAGGCGCATTGAGAATGGGGGGTGCCACGCGATGACTCTGAGGTCGCTAACACCCACAATCATTAAAATCGTCGCTTTCATCGCTCTCATCGGAGTCCTTTCATATGTCATCATCGCGATTCTGCAGCCGACCAACGAAGGGTCACCCAGTTCGCAGCGTTCCGCGGTGTTTGCCGACGCTTCCGGACTCAAGCCCCGCGACGGGGTACGACTCGCTGGAGTGAAAGTGGGATATGTAACGGCTGTCGATCTCGAGGGCTCAACAGCGATCGTCCGTTTCCAACTGGATGACGGTGTCGCGATTACCCCCGCGACGACTGCCGCTGTGCGTTACCAAAATCTGCTGGGGCAGCGGTATGTGGAACTCATCAATGCCGGACAAGGCGCCGACCAGGACTCGATCACACAGGTGGCACTCGAGAAGACCGTCCCGTCCTTCGACGTATCGACACTATTCAACAGTTTCAAACCAGTATTCGATACATTGAATACTGCGGAAATCAACGAGCTTCAGTCGAACCTTCTACGGGTTGCCCAGGGAGACGGTCGAGGTATCGCACCAGTCATGAAGCAAGTCGCGAACATCACTGATTACGGGAACCAGCGTTCAGAGATCATCACCAATATTGTGACGAGCCTGGGGCAGGTGTCCGACCAGTTGATGGGGCGCTCCGCTGAACTGGTTGAGTTGATAGACAAATTGGGGTCAATCGTCGATGCGTTCAGCCGCGTGAGCGATCGACTGCGGGCCTCGCTGCGAGAGGTCAACCGTTCGATGGCAAAGACTGTACTCGCCGGTGAGCAGATCGAGTCGACCTACGACACCAGCTTCGCGGCTATCTTTCAGAGATTAGTGCGGGAGCCAGGGGATACAGAAGGCCTACTGAATGGTGCCGTTCTCCTGAAGCCGCTCCTGGACGCCCTGGCCGCAACATCCAACGCGACTCCCCCGCCCTCGGCGGCAGGGTGTGCCCGAGGGGTGCTCGACCTACCGAGAACAGTGCAGATCGCCCTGATGGGTCAACGACTGGTGGTGTGCCAGTGACCCGTTTCTTCGGCAAGCGTCCGCATCACCGCCCGCAGCGTCGGCGGGACCTCATCCTGGCGGGGGTCGTAACGATGGTCACGGTGGCCGGTCTCGTCGCCGCCGGAGCTGTGTATATCTCGCCGCCCGGACAAACTATCTACAGCGCGGAGTTAGTCAATACCGGCGGATTGGAAGCTGGCGACCAGGTACGTATCGCCGGGATCAGGAAAGGCAAGGTAGCGTCGGTCGACCTGACCGGAACGTTCATCACCGTGCGGTTCCGGCTGGATGACTCGATTGCCGTTCGGTCGGACGCGACGGCGAACGTCCGTCTCCTCACCCCTATCGGTGGACGTGTATTGGACCTCGACCCAGGTTCAGGCCCGTCGGCCATTGACGGCGCGATCCCACTGGTGCAGACAGGCAGCACCTATGATATTTCCAGCACCCTGGAGACATCTACACCGGTGTTCCGTGACGTGCGTGGTGTTGATCTACGGCGCACGGCGGCGTTGCTACAGGATGCCTTTTCCGACGGAAACACCAATATCCCTGATGCCCTGCAAAACGCGAGCAGCCTGATGGACTTGCTGGAGCGTCAGTACGCACAACTCGACAAGACGGTGGCTTTGTCCGACGAGTATGTCGCTGCCCTCGCAAACCGCAAGCAGGTACTCGTGGACTTCCTACGCCAGCTCAGCTTCCTTGCCCGCACCCTTGGACCAGACATCGCCAACGTCCAGAGCGGGTTCGATTATCTACGTCGTCTTTTTAAGTTGCTGACCCGGCCGCTTGTCGCGTACCGCGACGGTATAGAACCATCGGTACAGCAGTTTAAGATCCTTCTAAACAAGGTGTCGGCCCAGATGCCCGCCTACCAAGACGCGCTGGCCCAGGTCGATCAGATCACCAGAAGACTGAGCATTCTCCTCAATGCTCCGCAGGTCGGACCTGCGAGTCCTGAACCGACCGTCCGCGTCTGTATCCCGATTGGTGATAACAAATGTTGACGGAGCGGATGCGTCGGCATCTGATCCCGATCGCCACCATTGTCACACTGGCAGTAGTGATCGGCGGCGTCGGAATCGACTATGCGACAGCCGACGACGACACGCGATCACTATGTGCGGAGTTTTCTGACGCATCAGGTCTGTACGAAGGCAATTCCGTCGCGATGCTCGGCAAGAAGGTGGGCAGGGTCGTAGGCATTCACGAGGAGGGACAGAAAGGTGTGCGTGTCGATATGCGGATCGACAAGACCGTGCCGCTTCCCGCAGATGTGGGTGCGACCCTGGTGTCCACCTCGATTGTCACCGAAAGACAAATCGAGTTCACCCATCCCTATCGTGGCGGAGAATATTACAAGTCGGCTGAGTGTATCCCACTGGAAAAGACCAGGACTCCACTGGGGATTAGTCAAACGCTCGACGCGATCAGCACTCTTTCAGACGAACTCGTCAAGGACGACGGACGTAACACGGATGCGATTCTTCAGGCACTTACACTCGTCTCGAAAAACATGGAAGGGACCCAGGGTGATATATCCGGCATTCTCCAGGACTCGGCCACGCTAATCAACGATCCGACCCGGCGTGATAGCCAGATACGCAGGATTGTAGCCAATCTCGCCACCTTAACCGGTGTTGCCACCGAAAACAGTACTGAGGTGACCCAGCTATTCGACAACTTCGTAGGCGCAATTGAGGTGATTGTTGCTTTCGGTCAAACATTCGGCGCCGCAACAGAGTACGCAGGCACCTTCGTCCCTATCCTGTCGCGCCTATCGTCTGACTTCGGGCCACCTATTTTCTCACTTGGAGATGCTGCGGTTCCCCTCCTCTCGCAAGCGGGCAAGCAAGAAAACATACTTGCGTCCGTCGCCGCTCGAACAGCTGACCTCATCGTTGAGCATCCAGATGCGAAGTCGATCCTGCGGGCATTCGCAATATCTGTACCACTGCAGGCCCTCAAGAACGCGTGCGCTCCTCCTTCCGTCAAGGACGTTTGCGCGACGGGTAACGAAGCGGCGACGATCGCCAACTTGATCGGAGGGCAACCTCGATGATGATCTACGGCTACCTTCGTCGTGTCACGGCCGCGATCGTGACGCTGTTCGTAGCGACTATCGCCCTCGCCGCCTGCAGCATCAGTGCTGACAACCCGCCGACCATCGGTGGATCATCCGCCCGAGACGGCTACGACATCGAGATCGAGTTCACGAGTGCTCTGAACTTGCCTGCCCGTGCCAAAGTCCTCTCTCGAGGGATTGACGTCGGTGCCGTCACCAGCGTCGCTTACGACGGAGGCCACGCGCTGGTTGCTGCCCGAATTGATAAAGACGCCCAGCTGCCGGAAGATTCGCGCGCGGAACTCCGCCAAGACACTCTCCTGGGCGAGATTTATGTGGCCATCCTTCCCCCTGCACAGCAGTCCACCCAAGGCTTGCTGCGCGCGGGATCGGTAATACCTCTCTCACGCACCGAACCGGCTGCCAACGTCGAGGACGTGATGCGGGGTATGGCTAACGTATTGGGCGGGGGTGAACTCGATAAAATCCATACCGCGATATCGACGCTGAACTCGACTTTTCCGAGTGACCCCGCCCAGTTCGATGCGCTCTACCGCACGACCTTGCGCACCGTGTCTGAGGTGTCTGCCAACACCGACAAACTCGACGTAATCCTGCAGTCAGCCGATCGCACACTCAAAGTGATCCTGGCCGACCCGTCAGGTACAGACCGAATGTTGACCAAGGGGGGAGTGAACTTTTATGGTCTGGGCTACTCGCTAATTGACGTAGCGCTACTCATCGCTAATCTGCGCGACTTCGCGGTATCCGCAGGCCGTATCGTCGACCCTGAGTATTCCCGCATCAAGGAAACGGTGGGCGCGATCGCGCCAGTGGTCGCGTCCATCGCGTACTCGGACATCTACTCCAAGGATGTTTCCGACAAGGCGGCTCGTGTAATACGCGAAAGGCTCATCCCATTCGTCAGCTCGCCAGATATCAACGTCTCCGATGTGTCTATCGATGGCCGAGAACTGGCGCGGCGTGATGCCGAGTCGTTCATAACCGTCTTGCGAGCGATCGGAATGATGCCATGATCCGCAGCACCCTCGTATCGCTGGTTGCCCTTGTCCTCGTTCTCCTCGTCGGAGCGACATACTTGATCATCGACGTGGCACGGGTAAACCCGTTCCGCACCGACTACGCGATCTCGGCCATACTCGAGAGCTCGGGCGGCCTTCTAGACACATCACCGGTAATGTTAGAGGGGGTGCCGGTGGGAAAAGTGACATCTATTCGCGTCACAGGTAATCAGCTCGCCGTCGACATGTCCATCGACTCCGACTATAAGATTCCTCGCGGCAGTGTCATGACGATTCAGAACCTCTCGGTCGCGGGAGAACAATACATCAATTTCATCCCACCGGGCACAACCACCAGTGAGTACTTGCGTAGTGGGGACCTAGTGCCCGCCGGCGCCATCCGCGTGTCGCAATCCGTTCCCCAGGTGCTCCCGAAAATGTCGGCAGTGGCGGACGCGCTCGATCCAGCATCGATTCAGTCCATCAACGAAACGATCTCGGCGGCAGTCGACGGCCGGCAAAAGGACCTCGACACGATCGGAGACATGATGCACCGCCTCGTGGACTTCGTCGGTGACGACGGTGCCGTCCGTACCACTGCGGACAATGCCGAGTTCCTCCTGGGCCTTATGTCGAACGTGGGCGGTGTGCTCAGCACCGCGTCGGTCCGGACCCCGGATGCCGTCGACGGTTTGGCGAGGATCCAACGTGCGTTCATCGTTTTCACTTCTACGTCCTACGACAAATGGCCACCGATCCTGAAGCTAGTGGAAAAGCTCAGCGGCTACATCCAGATACTCCAGCCCGATATTGTCGCCATTACCCGCGCGGTGAAGCCGGCGACGGCGAAAGTCGCAGACACATACATCGACTTCGGATCGATCGGTGATCTTCTGGCTCGAACATTCCCAGCGTCACATCGGGGGCAGGCGCAGATTCCGATCGCCGTCACGCCATCACCTCGCTGACGCCCGATGGATACCTCCTACACCAGCATTCACAGAAGGCAGCAAATGACGGCACAAGACAACGGACCAGAATCCAAGGACAGCAGCGCTGAGGATAAGCTGACTGCGGCTTCCGACAAAGCAGATCGCAGCGACGCCACTGGTGCTACAGAATCTGCGACGTCCCAAGACGGTCCCGCCCCGGACGAGGCAAGCCCCCCGACGTCCGATGCCAGGCACCGATGGAGATCAGCACGCGTCCAGGCGGTGGCCGCCGGCGCTTTCGTGGTGGCACTCGCGGTGCTGGCCGGCCTCTTTGCTTACCTCTACATTGACATGAGGGAAGCAAAGACGTCCGCGGAGAACGCTGCCACACAACGAGCGCAGGCAGCGCAGGCAGCATCGGACTACACCACAAAGTCGCTCACCTACAGCTACCAAAACACCGGCGCATTCTTTACCGAAGTGAAAGAGAATGCCAGCGATGCGTTGGTCAAGCGATACGACGATGTCGAACCCACCCTGACCCAAATCATGGAACAGGCCAAGGTCCAAGCGTCGGGACGCGTACTGGCGACCAGTGTCACCGGCAGCGCCAGCGAGAACCGGGGGGAATACACGGTGCTGGTCTTCGCCACCCAGAAGACCCAGAATGTTCAGAACCCTCAGCCGAGCGAACTCCCCACACTGTTGAAAGTAGTCGTGCTGAAGACCGAGAACGGCTGGCAGATCCAGGATTACGGACCTGCCGAATGATCCAGCGTCCGCCGCGAAAGGAGAATTTGATGAAAAACACCATGCAGGAGGTGCCGATGACAGTGTCATCGATACTGCGTCACGTCGCAACCAATCATACTGATAGGCAGGTGATTACTTATTCCGCGAGCGACTCTGCCCGGTACGCAACCTACGGCGATCTCGAAGAGCGATGCGCACGTCTGGCGAATGCTCTGCGCCGGGTCGGCGTGGTCGGCGACGACCGCGTGGCAACCATGCTGTGGAACAACCAGGAGCACCTCGAAGCGTACGCTGCGGTACCCGCGATGGGCGCGGTGCTGCATACGCTGAACATCCGGTTGTCACCGGCTCAGCTGCAGTTCATCGCGAACCACGCCGAAGACAAGGTCATCATTGTGGACGGGTCGCTGGTGCCGTTGTTGGCGGCGGTCTTACCGGGCTTGGCGACGGTTCGGGTTGTGTTCGTTACCGGCGACGGCGACACCTCCCCGCTCGACGGCCACGGCGTGACCGTGATGCGATACCATGACGCGCTCGCAGCAGAATCACCAATGTTCTCTTGGGTCGATCCCGACGAGCGGTCGGCTGCGGGTATGTGTTACACGAGCGGCACTACAGGCGATCCCAAGGGGGTCGTCTACAGTCATCGCTCGGTGTTTCTGCACTCCATTGCAGCGTGTACTGGTAACGCTCTGGCGATCGCAGAAGCCGATCGTGTACTTCCCGTCGTGCCGATGTTTCATGCCAGCGCCTGGGGTCTGCCCTACGCGTCGCTGATGGCCGGCGCGGACTTGCTCATGCCTGATCGATACCTTCAAGCGGCGCCGCTCGCCGACTTGATCCAACAGCATCGCCCCACGAAGGCAGGAGCAGTACCGACAATCTGGAACGATCTTCTTCAGTACGGTATCGCGAATCCGGGTGTCGACTTGTCATCAATCGACCTTGTCGCCTGTGGTGGAGCTCCTGTCCCGCAGTCGTTGATCGAAGGGTTTGCGGACCGCTTCGGCGTACAGATTATCCAGGCGTGGGGCATGACTGAGACGTCCCCGCTTGCAGCGGTAAGTCGGCCTCCCGCCGGGATCAGCCCCACAAAGGAAATGTCGTACCGCAAGCGACAGGGACGGGCAATTTGCGGGGTGGAGATGCGCCTCATCGACGAGGGCGGCCTGCCGGTTCCCCGTGACGACAAGTCCGTCGGCGAACTCGAAGTGCGGGGTCCGTGGGTCACAGGCAGCTACTACCGGCTCGAGGACGCCGAGAGGTTTCGGGATGGCTGGTTGCGGACCGGAGACGTGGGACACATCAGCCCGGACGGGTACCTGACGCTGACCGACAGGTCCAAGGACGTCATCAAGTCAGGGGGCGAATGGATCTCGTCAGTGGAGCTCGAGAACTGGATCATGTCGCACCCAGATGTCGCCGAGGCCGCGGTTGTCGCGATGCCCGACCCCCGGTGGCAGGAAACAGCTCTCGCCGTGGTGGTTCCGGTACCGGGTCGCAAGGTGTCGGCTGACACGCTTCACGAGTGGTGCCTAAGAAATTGCCCGGAGGAGATCCCACACTGGTGGATCCCGAAGAACTGGACGTTCGTGGAGCAGGTACCGCGTACGAGCGTGGGCAAGTTCGATAAGAAGGTGTTACGCGCGAAGCATGAGCAGGGCGAGCTGCCGGTTGTATCGAATTAGCGCCGCTATAGGGCGCAAGTGTGCCCACCGAACGTCGTCAGCGTTCGGTGGGCACACTTCTATAGAAGCAATGCATTTGCCGATGGGGACTGCTGCACGGATAGGTGACAGTTTGGGTGTCATGCCGCGGCAGCGGCGGTGTTGATCATTGCTTCGAACTCGACAGGCGTCAACCGACCGAGGCGGGCTTGCCGGCGCCGGCGGCGGTAGGTCCGTTCGATCCAGGTGACGATCGCGATCCGAAGCTGCTCGCGGGTGTCCCAGCGTTGGCGGTCGAGCACGTTGCGTTGCAGGAGTGCGAAGAAACTCTCCATCGCTGCGTTGTCCCCGCACGCTCCGACTTTGCCCATCGACCCCGTGAGTCCATGAGTGTTCAAGGCGTGTACGAATTTTCGCGATCGGAATTGGGCGCGTTCAATCGGTCGATGCAACACTGGGTTGTTGTAGCGAGTGTAGTTGTTCGCCAAAGACTTCGGCGGGAGTTTTCCATCCAAGGACTTTTCTAGGACGGTTGTTGAGGGTGTAGGCGATGGCCTCGAGGTCCTCAGCTGACCACCGCGACAGATCAGTTCCCTTAGGAAAATATTGGCGCAGAACACCATTGGTGTTCTCGTTGGATGGTCGCTGCCACGGTGAGTGCGGATCGGCGAAGAACACCTGCGTTCCGGTGTCCATCGCGAACTGGGCGTGAGCGGACAGTTCCTTGCCGCGATCCCACGTCAACGTTTTGCGCAACTGCTGCGGCAGCGCGGCGATCGACGCTGTCAGTCCTGCATTCATCGCGATGGCACCGTAGCCACCGAGTGCGGGCCCGTTCTTCACAGGCGGCTGCTCACCCCAGCCCTGCTGGCGTGGCAGATGCACCAGAAGTGTTGCACGACTACGACGTTCAACGATCGTGCCGATCGCCGATCTCCCAGTTCCGATAATCAGATCACCCTCCCAGTGCCCGGGGACGGCACGGTCCTCGGCCTCGGCAGGGCGCTGACTGAACACGACATCGGAGGTGACGTGACCCTGCGGCTTGTTGCGCGAGCGGGCCCGCGGCTCCCTCAGTGCACGTCCGGTGCGCAGGCACGCGACCAGCTCACGTTTGAGCGCGCCGCGGCCCTCGATGAACAGGGACTGGTAGATCGCCTCGTGACTGATACGCATGGATTCATCATCGGGGAAGTCGACCTTCAAACGCTGGGAGATCTGCTCTGGACTCCACGCCAGCGACCACCGCCGGTTGGCCCGGTGCGGTTTGTTAAGCCCCTTCCATGGCGGTGGCGTGGGGCCCGCAGCGATCGTGCCATCGGGACGGCGGACAACGCCGGCCAGGCGGTCCTGTACGTACTCCCGCAACTCGACGTGGGCCACGAGCTTCGCTGTTTTCGGGCGCTTGGCGGCCTGCTGGGCTTTCCACTGCGCCACCAACGCCCGATACTCGAGCTTCCCGCTCCTGGTTGCGGCGTTGCGCCGTAGCTCACGCGAGATCGTGGCCGGACTCCGCCCGATCCACCGTGCGATCTCACGCACCCCACGATCCTGGGCGCGTAGCAGCGCGATCTCTTCCCGTTCGGCGAAGGATAGATAGCGGCCCGAAGGCTCATCCAGACTCAGCGGCCTCATGCCGCCAGCGTGGCGGAACCAGCGTGTACCCACCGGCACCGACACACCGACAGCGATCGATGCCTGTGCCGTGCTCACCCCCGTCGCGACCACCCGCCAAAACTCACGTTGCACCTGCCGCGACGGCTCCGGCCGCCCCGGCGATCGCATCGCCGGCCGAAGTGCACGATCAGCACGCCACTGCCGACGAACACCTACCGCCACATCGCTGGTCCTCCGACTCCAGTCCGCCGTAGCCACCGCAAACACCTCCATGATCATGGTGTTGCGACGACCAGTTGAATCCGCCTTGCACTCCGCGGTCGGAGTGGTGGATCAGCCCGGCCACGTCGTGGCCGGCACGCGACCGTGCCCACAATCCCATGTTCAGGGCGTCGAGGGCGAGGTCGGTGTGCATGGTGGTCGAGACCTGCCAGCCGACGACCATCCGCGAGAACACGTCCAGGACGAACGCCGCGTACACCCAGCCCGAGTGGGTGCGGATGTAGGTCAGGTCCGCCACCCACAACGCGTTCGGTGCCGCCGCGGTGAACTGACGGTTGACCCGGTCAGCCGGCCGGGGTGTTTCAGCTCCCTCGCTGCGCGTGGTCTTGCGTGTCTTGAGTCTCGCTATCCCTTGCAGCCCATCGGCTTTCATCAATCGCTCGACGGTGCAGCGGGCAGCACTATGGCCCTGTCTGCGCAATTGGGCATGCACCTTGCGGGCACCGTAGACGCCGAGGTTGTCGGCATGCACCGCGCGGACCTGGGTAAGGAGCTCCCGGTCACGCACCACACGAGGCGCCTCGGTCTTCTGGGGGCTCAGGTGGGCTCGTACCGTGGACGGAGCGATCTGGGCGGACGTATCGCGCAATGCCGCACAGATCGGATCGACTCCGTGTTCATCGCGGTGAGCCGCGACGAACTCCACGATCAGCGCTGTGGGCGGTCGATCTCCGCCGCAAAGAAAGCCGAAGCCTGCTTCAAGATCGTGTTCGCTCGCCGCAGTTCACGGTTCTCCCGCTCCAACGCCGCGATGCGGTCAGCGTCCTCACTCGTGGTGCCCGGGCGGACCCCGCCGTCGATCTCGGCCTGACGAACCCAATTGCGCAACGCCTCGGGATGGACTCCGAGCTGATCGGCGATCCGCTTGATCGCACCTCTCGACGAATCGGGATCTCGTCGCGCTTCACATGCCATCCGGGTGGCCCGGTCCTTGAGTTCCTCACTGTACTTGCGTGGTGCTGCCATGCTCTCCATCCTTCACAGGTTCGAGAGCCTCCGACAGACCCGGGGCGGTTCAACCACCAGCCAGCCGCGTACCAAGGTCAGTGCAGCTAGCGTTTGAATTAGGACGCAACTCATCTATCACGGGCGACGGTGCTGCGTCATGCTTATGCCCCTCCTACCTGTTGACGGAATGGTCGGGATATTCAGCGACCGACGCTTGTCAGATCCCCATGGGTCCGTCCGCGTGACTTTTGCGATGGTCAAGGGGCGAGCCGGAAACGGTCGATGTCACCCGGCCACCAGCTCGCAGTGCCCAGCAGCACCGCTAGCGCCGGGACTACTAAGGTCCGCACCAGGAACGTGTCGAGCAGCAAACCGACACCGATGATGAACCCGATTTGCACCATCACATCGATGGACCCGACCATCAGCCCAAACATGCTGGCCGCGAATATCAACCCAGCCGAGGTGATGACCGACCCGGTGTAAGCGACGGTACGCATTACGCCGACCCGCACGCTCCACCTCGTTTCCTCTCTCAGCCGTGACACCAGCAGCATGTTGTAGTCGGCGCCCACCGCCACCAAGACAATGAACGACACCAGTGGCACGGGCCAGGCGATCCCGGCACCGAGGATGTGTTGAAGTACGAGCACACCAATACCGAGAGCCGCCATGTAGTTCAAGACGACGGTTGCAAGGAGATAGACAGGTGCAACGACGGCCCGCAACAGCAGCATCAGGATCAGACCCACGATGAGAAGGGTGGCTATGCCGAGCAGTTTGAAATCGTACGACAACAGTCGCTGGACGTCGGCATTGATCGCAGGAAAGCCCGCAACAGAAGCACGTCCGCCCTCCAGAGTGGTGTTCGGCATCGCGTTCTCGGCGACGCTGGACAGCTCGTTCGCCAGCGTCATTGCATCGGCAGAGTATGGGTCGTAGGCGGTCTGTACCGCATAGCGCACGGTTTTCCCGTCGGACGAGATGAACTGTCGAGCGACCTGACTGAACTGCTGGTCCTTGAACGCATCCGCGGGGAGATAGAAGCCGGTTGCCGAGTCAGAATCGCCGACCTCCCGTGCGGGAGCCCGAAGCTGTGCGGCGACCTGTGCCAGTCCACTGAGTAGCTGAAGGTTGCTGTCCACCAGAGCACCGACTCCGTTCGACAACTGACGCGCGCCGTCGGCAAGTGCGCCGACGCCGGATTCGAGTTGCGAGAGCCTGTTCCCGAGGTCCTGTCCGCCGATGGCTTGTAGTGCAGAATCCAGCGTTTGAAGAGAACGCTGCAGCTGTGCAATGTTGGTCGAGCCTGGCGCACTCACGCGGCCGAGCTGCGCGGCAAAGTCAGCCACCCTCCCAAGCGACTGATCATCCGCGAGTGCCCGGATGTCGGCCATTTGCGCGCGCAGTGCCGAGCACTGCGCGATCTGCTGGCACCACGGATTGTCTAACGCGGACAACGCCGGCGCGACCGCATCTGCCGCAGACTGGGCCCGACGTGCGAGTTGAGACAGCTCGGGCGCTTGCTTGGAAAACTGTCTAAGCCTTGGGGCAGCGTTCGCCAGTTGGTTCACAAGCGGCCGATACTCGTCGAGCTGCGGGCCAAATGACGACACCTCGTCGAGCAACCCCGACAGCGGAGCGAGGTTGGAGGATATCTGGTCTTCTAACAGTGCCAGGCCTCCGGCGAGCTGCTCTGACCCCGCCTTCAGGACGGCCAGATCACCCTTGCGGGCCTGTCCATCACCGGTCTCCTCGGTGATCTTGGTACCGATCTGATCATTCTGCCAAGATAATTGCGCCTGCTCTAGCTTCTCACCGGTCGGCCGCGTCACGCCAATGACCCTGGTCACGCCGGGAATCTGCGCGACGCGGGAGGCTAGCTGGTCGAGGTCGGCAAGGCCTTGAGCCGTGCGCATGTCGTTCTCGGACTCCACCACCAAGAATTCTGAGATGATGATGTCTTTCGGGAAGTGGCGGTTGAGAAGCGCGTATCCTTCGTTGCTCCCTGTGTCAGGTGGCTGCCCCTCGCGATCGTCGTAGGTGATCTGAATTGTTGCGGCGACCATGGCGAGGCCGATCAACACGACCACACTGATCGCGAGCAGAGGGACCGGCCGCCGGATAACCATGACTCCGACTCTTCTCCAGTAATCCCGCGTCAGGTCACGGCGGGGAAGGCCGGCGCCTTTCTTGGCAGCGAAAGAGAGTACGAGGGGCAGCAATGTCACCGTCGCCAAGAATGCGAAAGCTATGGCGATTGCGCAGGCCGGACCCAAAGTGTTAAACACACTGAGCTTGGCGAAGGCCATAGCCAGGAACGCTAGGGCCACAGTGCCCGCCGACGCTAGAACCACGCGGCCGATAGTTGCATTCGCGTGGGCGATAGCGACATCAGGAGAGTAACCCGCTCGAATACCTTCATGATAGCGGCTGATGAGGAACACCGAATAGTCAACTCCGGCACCAAAGATGATGACGGTCATGAACATTGACGTGAACTGGGATACCGGCATGCCCAGCTCGCCCAGTCCAGATAGAACTCCGCGACCCACAGCCAAGCTCATGCCCACGACAAGCAGCGGCATCAGCGCGGTGAAGACCGAACGATAGACGATCAGGAGGATCACGGCGATCAGCAGCACGGTGGCAACAGTGATCAGGACCAGATCCGACTCGCCCACGGCGAGTTGGTCGCTAAAGGTCGCGGGCGGGCCTGTCACACGGACTGTCGTCCCACTGTCACGAAAGATACTCTCAGCGATCTCACGCACCGCTGCGACCGCCTCCGCGGTATCGGGTCCCCCGAGTGTGCCGGCCACTCCCACGGGCAGATACCAGGCTTGCTTGTCTTTGCTGAGAGCCTGACTTGCGGTGAGGGGATCGCTCAGCAGGTCCCGGACAGCGATGACGTGCCTGTCGTCCGCCCGCAGGGTGTCGACAAGCACGTGATATCGATCGCGGGTGTTGTCGGACAGGCCTGCACTGTTCTCCATCACAACGAATACTGTGGTCTTGGCGCCGCGCTCGTCGAAAGATGCACCCATACGGTCCAAGGTCTGAAAAGACGGGACTCCGGCCGGGATCGGATCCACAGATTGTTCCCGTATCACTGACTCCAGTTGAGGAAAGAGAAGGCCTAAGCCGATGGCGGCGCCGAGCCAGACCAGCGTCACAATTCCCTTGCGGCGGAGGGTAAACCATGCAACCCGCTCAAGGGTCGGACTGTACTCGCCGAGTTTCTCGCCCCCTCTCGACGGGCGGGTTCGAATGGGAGACGAACTCACCATGTGCAATATCCTCTCGACCTGAAGTGGGCGACCCAATCGTGCGGACCCGTTTCGCGAATGTCCGTGCGGCGGTGGATGGTTGTCACTTGTGGTGGTGCTCGACCATGTTCTCGACTTCCTCGAGAGTGGTGGGCAGGTGGTATGGCGGAGTGCTCTTGCCTGAGATGCGGTATCGGCCCCAGAAGTCGGGATCCCCGACGACACACTCCGCTCGGCCCTCGGGGGTCGTAAATACAGCGATCGCGCGGGCGCCTTTCAGGAGCCCGTCGAGCTCATCATTCTTCTGAATCCGGCCATACCAGGTGTACAGGCCGTTCAGCGGCTGGAAATAGCCTTTGATCTTCGCTTCGACATGGATCTCCGCCCCGCGGCACACCAGGGTTCCTTCGCCGGAGTAGTCGAGGTCATGGTCGTCAGACATGCAGTCCTACCTTCTTCGCACTGAGCGTTGACAAATATCGCAGTTCGTGGATACTAGCAGTACCAGATACTATGAGTAATGGGTACTGGGCGCCAGGCCCCGACTCCCAGCCTTGAACGACCGAGGAGAAGACATGACCGTGCAGGATGTCCAGATGAACCCCGACTTTTCGAAGGAGGGCATGGCTCGGGTGAACGGGCGTAAGCCCGTCGACATGGAACGATCTGCGGGTCGATTGCTGCGGTCTTCCGCGGAGAAGTTCTACGACGCGGAGATCGACATCGACTGGGAGTCGCCCTGGGAGGAAGGCAAGTGCTTTCTGCCAGAGCATCGAGTGTCGCTATACGGCACCAGGCTGTGGGACAAGATGACTGAGGAGCAGCGTCGCGAGTTGGGGCGCCATGAGATCGTGAGCATCCTCAGTTTCGGCATCTACGCAGAGAATCTGTTGAGTTCAGCGCTTCTGCGCATGTCGGCGAAGGGGGCTTTAACCGATCAGAAGTCTCTATACGCGTTGACAGAGATCGGCGATGAGTCCCGCCATTCCACTATGTTCGCGCGCCTCATCAACAAGACGGGCGTGCCCCCCTACAAGCTTCCTAAGGGCTTCTTGAGCTTCGCGAAGATCCTGCATTTCGTCCCTCTCGGGCCGTCGGTGTCTGGAGCTACGCTGTTGATCGAGGAAATCCTGGACCGCGCCCAGCGCGAGGCGATGAACGACCCCAGTATGCAGCCTCAGCTTCGCCAGCTCATGAAGATCCACGTCCTTGAGGAAGCCCGTCACATTACCTTTGCGCGACTGGAGATGATCGAAGGCATGCAGCGTCGTCGTAAGGCGACGCGCGCTTGGCACCGAGGGGTGCTTGCCGTCATCGCGAACCTGGCGTACCCGCTGCTCATTAATCCGAAAGTGTACCCCGCAGTGGGAATTAGTCGCTGGCGTGGCGTGTGGGCGCAGCAGACCAGCCCAAACTATCGGACCAACCTGCAATTTATGTCGGAGCCCATGATTCGGTTCTTCCATGAGGCGGGAATGTTGGAAGGCAAGTTCACAATGGCCATGTGGCGTGCGACGCGGAGCCTTCCCGACGATCTTCGCTGATCTCCGTTCACGCGGCCGAGCCGTCGTGATCGACATCAGTTAGACCTGTGCGGAGCATTCTCGATGGCTTCGCGATCACTTCCGCCTCAACAGATCACCTGCCGCCACTGTGCGCAGGTGATGTGTTGTGCGATCCAACCTACGAGGGAGAAAGCATAAACATGGCATCATCGACTACCCGGCGCGCCTCGCGCGCAACCGCCAAGACGGATTCAACCAACGACCCGATTTCGACCAAGATTCTGATTATTGGAAGCGGGTTCTCTGGTCTCGGGATGGCCGCGCAGCTTAGACGTCGCGGGTATAGCGATTTTCTGATTCTGGAGAAGGCAAGCTCCGTCGGTGGGACCTGGCGCGACAATACCTATCCGGGCTGTGCATGTGACGTTCCGTCGCTGATGTACTCGTACTCATTCGAGAGTCGAGGTAGCTGGTCGAAGGTGTGGTCGTCACAGCCAGAAATTGAGCGGTATCTACAGGATGTCGCGGATAAGCGTGGCGTGACACAAAAGATTCATTTCGGTCAGAAGTTGGTTTCTGGATACTGGAGCGAGTCGGAGTCGCGGTGGCACCTGCGTACTGAGTCCGGACGTGAGTACATTGCTCAGTTCGTGGTGTCAGGAGTCGGTGCGCTGCATATCCCCAATTTTCCCGAAATTTCGGGGATTGAGGACTTTAAAGGCGAAGCGTTTCACTCCGCACAGTGGGATCATTCGGTGGATCTGGAGGGCAAGCGTGTCGCCGTGATCGGCACTGGTGCCAGCGCTATCCAGTTTGTACCTTTCGTGCAGAAGGAGGCCATGTCCCTCAAGGTCTTCCAGCGAACCCCTGCCTGGGTCCTACCCCGCAAGAATTTCTCCGTTCCGCCGGCCCTGCGGACTCTTCTGAGTAAACTCCCGATTGCACGTCGTATCGCCAGGTGGTCGGTGTACTGGGGTGCGGAGAGCCTGGCCTTCGGCCTCAACGGTCACTCTAACCTCATGCGGCCAATTGAAAAGGTCGCTCGGTGGAACATTGAACGCTCCATCTCTGATCCGGCATTGCGCAAGAAACTGACCCCGTCGTATCGTATCGGCTGTAAGCGGATTCTGGGGTCAAACGACTATTACCCGGCGCTTGCGGCACCTAACACCACTGTCATCAGCGATCGGATTGAGAAGGTGACCGCTGATTCCATCATTTCTTCAGACGGTGTCGAGCATCTCGTGGACGTTATAATTTATGCGACCGGTTTTCACGTGACTGATGGTTTCGATCAGCTCGCCCTGAAAGGTGCCACTGGCGAGGATCTCCCGTCCCACTGGCATCAGACGGGGATTAACACGCACCTGGGCATCACGACCGAGGGTTTTCCCAACCTGTTTTTCCTCCTCGGACCCAACACGGGCCTCGGCCACAACTCAGTGGTGTTCATGATCGAGCAACAGATCAAATACATCATGAAGGCCATCGACACAGTAGAAAGCCGAGGCGCTGAGAAGGTTGACGTACGCCCGTCCGTGCAAGAACAGTTCAACACCGACATCCAGCGGAAGCTGGCCAAGGGAGTGTGGACCAACGGCGGCTGCACGAGTTGGTATCTCGACTCGCAGGGCGTCAACCGGACCGTGTGGCCGGGCTTCACATGGCAGTACTGGCGCGCCACGAAAGATTTCGAGCCCGCCGAGTACGACATCGCCTGAGCCCGAACGCACGGAGAGACACGATTCGAAGAGATGGTGGGACGACGGTGAGCAGTTCTAATCGGCATGACTATACCGGCAAGGTGGCAGTGATCACCGGTGCCGCGTCAGGGATCGGTCGGTCTCTGGCACTCCAGTTGGCGGAGCGAGGTGCCGCACTGGCACTGTCCGACATTGATGAGATGCACTTGAAGGAGACTGCAGAACTTTGCCGCACCACGCATGGGGCAACGGTAACCGCCGCCGTACTAGACGTTGCGGACCGCGCTGCTTTTCAGGACTATGCCGACGGAGTGCGGTCAGAGTCGGGCCACGTCGACATGGTGTTCAACAACGCCGGCGTGGCCTTGGGCGTCGACGTGGTCGACATGAGCTGGGAAGACTTCGACTGGCTCATGGGCATCAACTTTGGCGGAGTCGTTAACGGGTCGAAGGCGTTTCTGCCTCACCTGATCGCGTCCGGGGACGGACATCTCATTAACACGTCGAGCGTCTTCGGCTTGATCGGAATCCCCAGCCAAAGCGCCTATAATGCCGCGAAATTCGGCGTCAGAGGCTTCACCGAGGCGCTCCGACAGGAGATGAAAATCAGTCGATACCCGGTCACAGTGACATGTGTGCACCCGGGGGGTGTAAAAACCAACATCGTCAACAATGCCCGAGGCGTTTCCGCCATGGGGGCAGACACCGCGACTGTCGCCTCGCTGTTCGACAGGATCGCACGAAGCACCCCGGATAAAGCAGCGGCGACAATCCTCAAAGGTATGGACAAGAAGAGAGCGCGAGTGCTGATCGGTGCGGACGCCCGCGGTTTCGACTTCGTGGCACGGGTGATCGGTCCCCGCTACCAGGACATCGCGGCGCCACTGACACGAGCGGGTTACGCGGTCGCACGTAGACAGGGGATCCTCAAGTGACCGTCGAACCCGATTCACGTCCGGCTGCCGCGGCGGCCCGCTCACGCACCTTAACCGTCTCGGAAGTGATCCAGGAAACGAAAGACTCCGTTACCATTTCGTTCGAAATCCCCGACGCCATGGTCGAGGAATTCAAGCATACCCCAGGGCAATTCATCACCGTCAAGATCCCATCTGATCGGACCGGTCATGTCGCACGGTGCTACTCATTGAGCAGCTCGCCTCACGTCGACGACTTCCGTCTCGAGATCGGCATCAAGCGGACCGAGAACGGTTACGCATCGAACTGGCTGTGCGATAACGCGATTACGGGAATGGAATTGACCGTCCTCCCGCCGTCAGGGCATTTCACGGCGAAGAATCTCGACGTTGATTTTCTATTCTTCGCAGGAGGAAGTGGGATCACTCCGGTCTTTTCGCTGATTAAGTCGGCACTTGTGTGCGGCGGGGGCGAGGTCACACTATTCTACGCGAACCGCGATGCCGAGTCGATCATGTACGGGGGGCAACTGACGCAGATCGTCTCCGAGTTTCCTGAGCGTTTCACCGTCTTCCATTGGTTGGAGTCGGCTATGGGTATTCCGACGCCTCAGAATGTCGAGTCCGCCATACGTGAGCACCGCGGTGCACAGATCTTCACCTGTGGTCCGGCGCCGTTCATGGATCTGGTGCAGAAGTCGGCGGAGGCCTGCGGTGTCGAGCACTCCTCGGTACATCGAGAAGTCTTCCAGTCACTGACCGGGGATCCGTTCGATACAGCCACGATGCGTCAGCTTGGTGACGACGACGGTGTGGCGACCGCTACGGTCTATCTGAATGGGCAGTCCATCACGACTGAGTGGCCGCGCAACACGCCGTTGCTCGACGTGCTACTGGCCCAAGGCCACAATGCCCCGTACTCCTGCCGAGAAGGAGCCTGCAGCGCGTGTGTATGCAAGCTGGTCGAGGGTGATGTAGAAATGGCCCAGAACCACATCCTCGTTGAGGGTGATGTTGCCGACGGTGAACGGCTCGCATGCCAGGCACTTCCGCTGACGGATTCTGTCACGGTGAGCTTCGATGACCTCTGAGTTTGCGAGTGCGTCGCGAGGATCGCGTGACCTCGAGGTCCTTTCCTCCGACGGGACCAAGTTGTTCGCTCAGGAATTCGGTCCGGGCCGGGATGCTCCGCTCCTAGTCTTTAGTCACGGCTGGGCTTGTCAGGGACGTTTCTGGCGTCCGCAGGTCGAGCAGTTCGCGGCGACGCATCGGGTGGTGGTCTACGACCAACGCGGACACGGGTTGAGCGACCGGGGCCGGGTACCGTTCTCGGCGAAGCTCTTGGCCGATGATATGGAGGCCGTAGTCCGGGCAGTGGCGACTCCCGCCGACAAGGCTGTCGTGGTCGGACACAGCATGGGAGGCATGTCCATCATGAGTTGGGCGGCTGAGTACCCCGCCTCGGTTTCGGAGCTGGCCCGCGGAGTAGTACTGGCAAGCACCGGGCCATCACAGTTGGTGGATCGGTCTACATTGCTCAAGGTTCCCCGACAGCTACGACCGAGACTTGAGCGGGCCTTCGCGGCCAGTCTTGCAGTCGCCGGACCCGAGATGCAGGGGACGCGTTTGTCTCGCCGCCTGATTCGTTACGGAACCCTGGGCCCGGGCGCGACTGCCGAGGTAGTCGACGAGTGCGCCGACATCGTGTTGCGATGCCCACCACAGGTGCGCGGGATGTGGGGTTCAGTGTTGGCGACAATCGACGTCAGTAAGGGGGTTGACTCGCTGGAGGTGCCGGCGACGGTCATCGTAGGTGATGCCGACAGACTGACCCCAGCGACCCATTCAGTGGATCTCGCAGCGCGCCTGGGTCGGAAGGGCGTTCTATTTGAATTCACTCTTCTTGACAAAGTCGGTCACATGTCCAACCTAGAGGCCGTCGAAGACTTCAATTCAGCCGTGGCCAGATTAGACAAATCCGCCTGACGCGGGTCTCGTCGACCCAACCCATGTTCACTGGCTAGTGCGTCACTGGCGCGACAAGTCAGCCATCCTGATAACGTAGGAGGTCATGTCTGTAGTCCGTCGCATCTCCGCGGCCCCGGTGAAAGTGCAGCGACGTGTGCGCGACGCTCGAAGCACGCGCTGGGACGACCACCGCGCCGTCGTCAAAGCTGAACTCGTCGATGCAGCGATACGCGCGATCGAAAAGTTCGGCGATGCCGTGAGCATGGACGATTTTGCGGAAGAGGCTGGTGCGTCGAAGCCTAAGCTCTACCGCCATTTCGGTGACAGGGCTGGGCTCTACTCCGCCGTGGCAGCCCGTCTGGGTTCTATGATGTGGGAGTCAGCGCAGTCAACTCTGCTCTCCGGACAGGCAGACAGCACCGTCGACGAACTTTTCCGTTCAGCGGTGTCCGCATACGTATCCTTGGTTGATGAACATCCAGCGGTCGTCCGTTTCCTCATGACGAACCACATGTTCCAGTACTCTGAGTCCGGCGAGGGTGGGGCCGCAGATCAGCTGAGATCGGCAATGGAGATTATTTCCGACGAGTTCGCTCGTGGCCTCCGAGAGGTCGATGCCGAGGAGTCCCCCGTCGCCGTAGCAGTAGCCTCCATTCTGGGGGCTGGCCTATCAGCGACCCAGTGGTGGATCGATCACGGTCGGCAGAATGGAATGAGCAGGGACATGTTTGCCGCGCACCTGTGCCAGACCTCGTGGGGGATCATAGACGGCGCTGCAGCCACAGTAGGCGTTCGATTCCATAGGGACAGGCCCTTAGGCGACCCTGGATTCGCCACTCGCCTCGACGCCGTCTGATCCCCTTCGTACGGGTGGTCCGCCCTGTGTCACGCACGCGGCAGAACTGCTCACACAAACGGAGCGCATTTCACAATCCTGACTGCTGGCTGTCATGGGGGATCATCCTTGGTCGCCGCTCATCTTAGTAGCGGAGCGCTACAGACGGTACTGTTGACGACAGTGCCACAGTCGTGGCGGCACTCATAAGGCCCCCCTCGAGCCTTCCATCGGTACCGCCACTGGCAGTTTCGTTCTGTTACCGACGGTATTGGTGTGCAGTCAGAGGTTCTTGATTTGGTTTCGTAGGGAGTGGCCAGGGTGGAAACCATCGATTTCGACGATGTTGACCCGAGGCGGGTTCGGTCGCGTCAGCGTTTGTTGGATGCTGCGGTGACCTTGCTGAACAGTGGCGGGGTCGAAGCCGTTACCGTGGAGGCGGTCACTCGACTGTCTCGTGTTGCTCGCACCACCTTGTATCGTCACTTCGAGAGCTCCACAGATCTGGTGGCGGCTGCCTTCGAGCGATTGTTGCCTCAGGCCGAGACCCCCGAGACGACGACGTCGATCCGTGATGACCTGCTGAAGCTGATGCAGCGGCAGGCTGAGCTTATTGAGCATGCACCGCTGCAGTTGACGACGCTGGCATGGTTGGCAATGCTTCCCGAGCAGCCCCGGCAATCCGGGCAATCCGACGGGGATCAGAACGCGCTCGCGCCACTGCGTCGTCGAGTCGTCGAGCAGTATCGAGAACCATTCGATCGAGTTTTGACGAGTGACGTGGCCACGGCTGAGCTCGACAACTTCGATTTGACCATGGCTGTCACCCAGCTCGCGGGCCCGCTGATCTTTGCCAAGCTCACGGGCATTCGGTCGATGACCGTTGGCGATCTCGAACAGCTTGTCGACGATTTCCTCATGGCCCACCGGCGACACCAAACCTCCTGACCTCCTTCCCCATCTACGGTACTGCTAGTACCGTAACGATACCGTCGGTTTCGTAGACGGGCTGGGTCGAGGGTGAGGTGCTGCATATGGTGGTCCAACGTCCAAGTGGTGGGCGCTTGGCGGCGCGCCGGTTGGCGGAACGCAGCGAGTACAGCACGACATTGGGGCGGTTGGCACGGTTCACCTTGGCGCACAGATTCCTCGTCATCGGGGCGTGGGTGGCTGTGGGTATCGTCTTGGCGATTCTGTTTCCCCAGCTGGAGACGGTGGTGCGGCAGCAGTCTGTTGATCCGATCCCTGCTGGGGTTCCATCGTTTCAAGCACTCGATCAGATGGGTGGTGCGTTCGGTGAGAAGGGCGCCAAGACCACTGTTTTCGTGACCATGGAGAACCCGAACGGGTTCACCGACGTGGCGCGGGAACGCTACGACATGCTCGTTCTGCAGCTGCGCGAAAATTTCGACGATGTGCAGTCAGTGCGGGATTTGCTTTCCGATCCGACGACGGCCGGCCAAGCCTTGAGTGAGGACGGGCAAGCCTGGTACCTGCCTGTCGGGGTCACCGGAACATTGGGAGGGCCAACGGCCACGCATGCTGTGGAGACCGTGCGCCAAACCGCGCAGCGCGTGTTTGACGGTACGGGCACCACTGTCCATGTCACCGGGCCGACAGCCACTTTCAGTGACCAGATCGTCAGTGCTGAAAGCGATTTAGTCGTGATCACTCTGGCGACGGTGGCGCTTATCGCGATCATTCTGTTGATCGTTTACCGATCGCTGTTCACCGCGCTGGTGCCGTTGTTGGTGATCGGTGTCAGCCTCGGCGTGGGCCGTGGCATCTTGTCCGCACTCGGCGAACTCGGTATGCCGGTATCGCAGTTCACCGTCGCGTTCATGACCGTCATCCTGCTCGGAGCCGGGGTCGACTACTCAGTCTTCTTCATCAGTCGCTATCACGAACGGCTACGCCAGGACGCCACCACCGAGGTTGCGCTCGTGGACGCGACAGCAACTATCGGACGGGTCATCCTGGCTTCAGCTGCCACGGTGGCGCTGGCCTTTTTGGCGATGGTCTTTGGTCAGCTGAGCGTGTTCTCCACCTTGGGTCCGGCATGCGCGATCGCCATCCTCATCGGATTCCTCGCCACGGTCACCCTGCTACCACCGGTGTTGCTGTGGGCGGCACGATTCGGCTGGGGCGCACCCAGGCGAGATCTGACCCGAAAGTACTGGAATCGCGTCGCCGTGCTCGTCGTGCGGCGTCCTGTGCCGCTGCTGGCACTAACCCTGGTCGGGCTAATCGTGCTTAGCGTCTTCGCGACGGGCATCCAGATCACCTTCGACGATCGTGAGGGGCAACCCGCGACAACCGACAGCAACGAAGGCTACGCGTTGCTCGACCGTCATTTCCCTCAAGACGTCACTATCACCGAGTTCCTCGTCGTAGATGCACCGATCGATCTCCGTACTGCCAGCGGGCTGGCCGATCTTGAGCAAATGGCCTCACGTGTATCCCAGATCCCCGGAGTGACTCGAGTCATCGGCGTTACCCGTCCCACCGGGGACAAGCTCGAGCAAGCCGAGCTGTCCTGGCAGAACGGCCAGATCGGGAACCGGCTGGCGGGTGCGGTCGACGATGGCCAGAACCGCCGCGGTGACCTCGAACAGCTCCGTACAGGCGCATTCCAACTCGCCGACGGGCTTACTCAGCTCGACACCCAGGTACGCACCAACTTGGCCCCCCTGGCCGGCATCCTCGATCAGGCAAGCACAGCCGGGCAGCAAATTCAGCAGTACCAGCCACTACTACGCCAACTCGCCGCATCTGCACCAGCGCTCGATCGCGCTTCTCAGAATGCCCCACAGCTGGCCGCGCTCACCCGCCAAACATCTGCAGCCCTGGCAACAGTGACCTCGATCCTGCCCATCCTCGATAATGCGCCCTGGTGCACCCAAGTCCCGCAGTGCGCAGCTCTGCGCGCGCAGACCCGCAATCTCGACGCCCTACTGAGCAACGGGACCCTCGACCAGATCGCCACGCTGTCAACACAACTCGCGCAGCTGGATACACCGATCTCAACAGTCACCGACCAACTCACTTCCACCGTCAACTCACTGGGCTCCACGCTGGGAAGCATCAGCAGCCAAGACCTTCCCGGCAAGCTCACCCAACTGCAAACAGGTATCAGTCAACTCGCGGCGGGATCACGCCAACTCGCCGCCGGTGTATCCGCGCTGATCGACAGCAACCTTCAACAACTCGCCGGGATGGCCGCGCTAGCCACACAACTACAAACCTCCGCCCGCGAGACCGCCGGAACAAACTCAGCAACCGGCTTCTACCTCCCACCTCAGGCCAACGCAGACCGCCGTTTCGTCGACGTCGCTCGCCAGTTCGTCTCGCCCGACGGCCATACCGTGCGCTACGCAATACAAACCAGCTTCGACCCCTACAGCACCGAGGCCATGCAACTGGCCGACACAATCACCGATGTCGCACTCGCCGCCAGACCGAACACAACCCTGCAGGACTCCAACATCGCGACAGCCGGGTTCCCCGCCATCAACGCCGATCTGCAACGTCTACTCACCGAAGACTTCCGACTCCTAGCGTTGGCCACCCTCACCATCGTCGGCCTGATCCTGATACTCCTACTCCGAGCACTCATCGCGCCGCTATACCTTCTGGGCACCGTCATACTCAACTACACCGCGGCACTGGGTATCGGCGTCCTGATCTTTCAACACATCCTCAAAACCGACATCGCCTGGCCCGTACCACTACTGGCCTTCATAGTCCTCGTCGCGGTCGGCGCCGACTACAACATGCTTCTCATCTCTCGCCTACGCGAAGAATCCCAAAACAACATCCGCATCGGCGTCCTGAGAACCGTCACCAACACCGGATCAGTCATCACCTCGGCCGGCCTCATCTTCGCTGCCAGCATGTTCGGACTCATGGCCGGATCCATCTCGATCATGACCCAGGTCGGACTCATCATCGGCATCGGCCTGCTGCTCGACACCTTCATCGTCCGCACCATCGTCGTGCCGACCATCGCCACACTTGTCGGCAGAGCAAGCTGGTGGCCGAGTACCCGAACCGACACGCATCCAGCGTCCCGCTAGTACGCACGCACGTGCCGAGATCTGACCGGCCCCGCCAGTCATCCAGCCATCGCGCCCACCTCATCGACTGACACCCGCTCGACGGTCGGCCGCGGCACCACACCCGACCCACGTGCGAGCGCCCCTCGCGTCGTTGACGCTGGTAGAACTCGCAGGAGGGCCCGTCGCGGCGTTGGGGACTGTCGCTGATTCGGTGTAAGTGGTTTTGATCGCCCCCGGCGTGGGGCAGGAGGAATCACGACGATGACCGACACAATCGGGGGCGTGGATGCCCCGGTGGCAGGGCCGGTTCAGACCGGTCAGGAACACGATGTCACCACCGCGGATGCGGTGCGTGAGCTCTCGAAGGCCGAGCAGGCTTTGGTGAGCGATCTGGTACGTAGCTCACGCGCTCAGGGAGTGGCTCTGACCGGTCCTGACGGGCTGCTCAAAGCGCTGACCAAGAGCGTGCTCGAAGCCGCGCTCGATGAAGAGATGACCGAACATCTTGGCTATGACAAACATGACGTGGCCGGCCGCAACACCGGCAATTCACGCAACGGCACGCGCACGAAACGGGTCCTGACCGACGCGTGCGGGCAGGTGCCCATCGAGGTGCCCCGCGACCGCAACGCCACCTTCGACCCGGTAATTGTCGGTAAGAGCAAACGTCGCGTCACCGATGTGGATCGGGTAGTGCTGTCGCTGTATGCCAAAGGCCTCACAACCGGCGAGATCTCAGCGCATTTCGCCGATGTCTACGGTGTCAACGGCGGCTGAAAACTGACCCCTTATCGACGGTTGAATTTTGACCCCCTTTGGTGTGGTTACTGGTCGGTGTTGACGAGTTCTCGTCGGGCTTTGGTGCGGTAGGAGTCGCCGTCGATAGCGATGACCTCGGCGTGATGGACGAGGCGGTCGATGAGTGCGGCGGCGACGACGTCGTCGGCGAAGACTTCGCCCCAACGGCCGAATGGCATGTTCGAGGTGATCAGAATCGAGCCTTGTTCGTAGCGACTGGCAATGAGTTGGAAGAACAGGTTGGCGGTGTCGGAGTCGAATGGGAGGTAGCCGATCTCGTCGATGATGATCAGTCGGTAGCGGCGGAGCCGTTTGAGTTCGGCGGCCAGGCGGCCGGTGGTGTGTGCCTCGGTCAGGCGGGTGGCCCATCCGGTGGCGGTGTCGAAGAGCACGGGGTAGGCGTTGTGTGCGGCTTTGATCCCGAGCGCGATCGCGAGGTGGGTTTTTCCCACCCCGGGTGGTCCGAGAAGGATCACGTTGTCGCTCTTGGCGATCCAGGTGCTGGTGGCCAGGTGGGCGATCACATCACGACGCAGTCCTGGAAGGTGGTCGAAGTTGAAGTCCTCGAGTGTTTTGACCGCAGGGAAGCGCGCGCCGCTGATCCGCAGCATGGTGCCGTTGGCTTCGCGTTCGCTGACCTGGCGGTCAAGAATCGCTGCGAGGTACTGCTCGTGGGTCCAGTTGTCGGTGCGGGCCCGCTCGGCCAATTCCGCCCAGCATCGGCGGATCGCTGGCATCTTCAACGCCCGCGCCGCGAACTCGATCTGTTTACCTGTTTGATTGTCGGACACAGTCTTTCACCTTTCAATGCTGGTGGATGTGGTGGGCGGGTGAGCTTGGGGCGGGGTGGCAAAGTTCACCCCGAACAGCTCGTCGTAGTCCGGTAACGCCCGGATCGGCACCTCGTGGCCATCAGGGTGGGCGCGGATGCGGGCGGCGTTTCGGGCCCGGTTGGCGAGGTCTTGGCGGCGGTAATCGCGGCGCAGTTCTTTGGCTGCTCGCACGTGCTGAGGGTCGGCGATGGTGACGTGGTTGGCCCAGCTGCGCGCGTGGTCGGCGACGGTGACCTCGCCGCAGAGGATGCGCACCTGCTGCAGGTCGGCAGTGATGTCGACGAACCGACCGATCACCGACGGGTGCACCGAATAGTCATTGCCGGCTACACGTACGTAGTAGTCGCGACCGAGTCGCACCCGGCTACTCAAGCCGATATGCGGTGCGGTCGGAGGTAGGCCGGTCATCTGCTCGAGGTCCTCGGCGAACACGTCACACGGGCGTCGATCACCGATCGCGCGCACCACTCGGGTGTTGGCATGATCGGCCAGCCACCGATCGAACTGGGCGGTGAAATCGGCCGGTGAGCTGAACTGGCGGCCCGGCAGGAACGAGCTCTCGAAGAACCGGTTGTTGCGTTCGACCATGCCCTTGTACTCGGGGTCTCGCGGTGGCGCCAGCTCCAGCCGCGTACCCAACGTGCCCACGAAGCCGGCCGCCAACGCGGTGGGTGTGCCCTTGGGGCCGATCGCGGCTTCGCGGTCCCACACCAGTTTGCGGGTCACCCCGCCCAGTTGCGACAGCAGCAGCCACATTCCCGTCAGGATGTCTCCGCCCTGGCGAGACGGGATCATCACCGCCGACCGGTACCGGGAGAACGCCAACGTCATCACCAACACCGGTAGCATGGCGAACTGATTGTGGCTCAGAGGGATTCGGTAGTCCGGAAACCACAAATCCCACTGTGAACAGCCGCCGGGCTGATAGATCACCCGATCGGCTGGATCTACCCCACGAAACTCTGGACGAATAGCCCGGACCCGGTCTTTGAGGACCGTCAACGACCTCGTCCACCCAACCCGCTCGGCGATCACCGTCGCCGGCATCGTCGGATACTCCCGCAGCAACGCCCGGATCTGCGGTTCGAACGCGTCGACCGCCGAGCCCGTCGCCGGCCGCGAGTACTTCGGCGCGGTATCCGAAGCCAACGCCGCACGAACGGTGTTGCGGGCCACCCCCAACCGGCGCGCGATCTCCCTGATCGGCACACCCTCACTGCGATGCAAACGGCGGATCTCTGCCCATTGCTCCACTGAAATCACCCTCCTAACAAGACGGGGGGGGTCAAAATTCACCCGTCGTCAGGGGGTCAGTTTTCAGGCGTCGTCAACATACGGTGCGTCGGTATCGAAAGACACTGAACCGCCCCGGGTCTGTCGGAGGCTCTCGAACCTGTGAAGGATGGAGAGCATGGCAGCACCACGCAAGTACAGTGAGGAACTCAAGGACCGGGCCACCCGGATGGCATGTGAAGCGCGACGAGATCCCGATTCGTCGAGAGGTGCGATCAAGCGGATCGCCGATCAGCTCGGAGTCCATCCCGAGGCGTTGCGCAATTGGGTTCGTCAGGCCGAGATCGACGGCGGGGTCCGCCCGGGCACCACGAGTGAGGACGCTGACCGCATCGCGGCGTTGGAGCGGGAGAACCGTGAACTGCGGCGAGCGAACACGATCTTGAAGCAGGCTTCGGCTTTCTTTGCGGCGGAGATCGACCGCCCACAGCGCTGATCGTGGAGTTCGTCGCGGCTCACCGCGATGAACACGGAGTCGATCCGATCTGTGCGGCATTGCGCGATACGTCCGCCCAGATCGCTCCGTCCACGGTACGAGCCCACCTGAGCCCCCAGAAGACCGAGGCGCCTCGTGTGGTGCGTGACCGGGAGCTCCTTACCCAGGTCCGCGCGGTGCATGCCGACAACCTCGGCGTCTACGGTGCCCGCAAGGTGCATGCCCAATTGCGCAGACAGGGCCATAGTGTTGCCCGCTGCACCGTCGAGCGATTGATGAAAGCCGATGGGCTGCAGGGGATAGCGAGACTCAAGACACGCAAGACCACGCGCAGCGAGGGAGCTGAAACACCCCGGCCGGCTGACCGGGTCAACCGTCAGTTCACCGCGGCGGCACCGAACGCGTTGTGGGTGGCGGACCTGACCTACATCCGCACCCACTCGGGCTGGGTGTACGCGGCGTTCGTCCTGGACGTGTTCTCGCGGATGGTCGTCGGCTGGCAGGTCTCGACCACCATGCACACCGACCTCGCCCTCGACGCCCTGAACATGGGATTGTGGGCACGGTCGCGTGCCGGCCACGACGTGGCCGGGCTGATCCACCACTCCGACCGCGGAGTGCAATACCGAGCCATCCGCTACACCGAACGACTGGCCGAAGCCGAAGCGGTGACATCTGTTGGCTCCAAAGGGGATTCATACGACAACGCGATGGCTGAGGCGTTCAACTCGCTGTTCAAAGCCGAATGCATCCGTAACCCGTGATGCGCCCGCGAGGCGGCTGGGCAGGTGTGGGCGAGGTCGAGATCGCCGTCGCTGAGTACGTCGAATGGTTCAACCACCGCCGCCTGCACGGCGAGATCGGACACGTCCCACCCGTCGAGTACGAGAGCGCCTACTGGTCGACCCACACCGTCACCAGCTACCGTGAGAACCCGGTCCCCGCAAACGCTGGAACCAACTAACCGAGCCTCCAGCAAACCCGGGGCGATTCACACCGTCTCCCGAATCACGGATCGGGTCATCGAAGAGATGGTGTCGTGGTGGGCACGCCCGCTGGAGAAAGTGTACGCGGCGGTGTTCATCGACGCGATCATGGTCAAGATCCGGGATGGGCAGGTGCGTAACCGGCCCATCTACGCCGCGATCGGGGTGGATCTCGACGGGCACAAAGACATCCTCGGCATGTGGGCCGGCGACGGCGACGGCGAGTCGGCCAGGTTCTGGCTGGCGGTGCTCACCGACCTCAAGAACAGGGGTGTCCGCGACATCTTCTTCGTTGTGTGTGACGGATTGAAAGGGTTGCCCGACAGTGTATCTGCCGCGTTCCCGTTGGCCACGGTACAGACGTGCATCATCCATCTGATCCGCAACACCTTCAAGTACGCCTCCCGCAAGTATTGGGACACGATCAGCGCCGATCTCAAACCGATCTACACCGCGCCGACCGCCGCTGACGCCCGGGCGCGGTGGGAGGAATTCGCCGAGAAATGGGGCACGCCGTACCCGGCGATCGTGACCCTGTGGGAGAGCGCGTGGGAGGAGTTCATCCCGTTCCTTGACTACGACGTCGAGATACGGCGAGTGTTGTGCTCCACCAACGCGATCGAAAGTCTCAACGCCCGCTACCGGCGTGCGGTGCGCGCTCGAGGACACTTCCCGAACGAGCAGTCCGCACTCAAAACGCTCTACCTGGTCACCCGGTCGCTGGACCCGAAGGGTACCGGTCAGACGAAGTGGGCCGTACGCTGGAAGCCAGCGCTCAACGCCCCGGCCATCACGTTCGCCGATCGTATGCCCGCAGCCGAAGAACGCTGACCCGCCGAGCAATCGGAAAACCGCCGCTTACACCGAATATCGGACAGACCCGTCGGGGCCCGATTCCCGCCGAGCTCGTGGTGAGCGTGCGTGAGACGCTGGGTGGGGGTCGTCCAGAACGGGGGGTGTCCCTATGGGTTTGTCAAGCAGCTGAAGCGATTGGGGTTCGGTAGGGCTCGCTGTGCTTGAGCATCGCGTAGAGGACGTCGCATCGTCGGCGTGCCAGGCAGATGAGGGCGGCGTTGTGTTTCTTTCCTTCGGCGCGTTTGCGGTCGTAGTAGGCGCGGCTGGTGGGGTCGTGCAGTGCGGCGAACGCGGAGAGGAAGAAGGCTCGTTTGAGTTTGCGGTTTCCGAATCGGGCGGGGTGCTCGCCACGGATGGAGGTGCCGGATCGGTGGGTGACTGGTGCGATGCCGGCGTAGGCGGCCAGGTGGCCTGCGGTGGCGAATGCTGAACCGTCGCCGACTTCGAGGAGGATGCGGGCTGCTGTGTAGGGGTCGTAGCGGATCTGGTTTCGCACCGCGGCAAAGTGGCTCCGCGCCATGTCTCGATCGTTGTCCGCGTCGCCGGTAGCATCACGGGTGGACGCCTGCACGGTGGCGTGGTCGAAGGCCAGGATACGTGACGCTGCGAGAAGAACTGCAGGCTTCCCGGTTGCCTCCTGTCGATGTCACAGGACCCGGGTCAGCGGGAACCGGCGTCCTGCTGATGGTAATGCTCCTGCGTGCGTTTGTGTGAACGCGGCGGCCCTGCTTAGCGTCCTCCTCGCGGACTTGCCGCGACAGGCCGGTTAGCCTGACAAGGATGCTGCGGCCTTTCGTAGTGACGCCTCCAGGGTCGTTTCCGCCTCGGGTAGAGCCGCCGCGAGGGTTGTGACGGATCGGAGCCGCTCGGATGAGGCGTGATCCTTCTGTACTGCTGCGCGTGCGACTGCAGTCCAGGATGTCGCCGCATGGTGGGCGTTGGCTGCAAGGATGGCGGTGGCGTGATCGCCGGTGAGGCGCGCGATTTCGTCGCAGCCCTGTGCCAGCAGTCGGCGGAACAGGCCGCCGCCGGTCCCCGCTTTCTCGATGAAGGCGCCGAGGCTGAATAAATGCATCTCGAGGTCGTCGGTCGACAGGGCTCCCCAGCTGCAGACGTCGGATGCGAGCGCGCTGGCAGCGTCGAGGCCGTGTGACCCGTGTTCTGCGGGCCCGGCGATCGTCGATGCGCCTGGGGTGCTCAGGCTCGCTGCGGATTGTGCGAATGCCTGTGCGGCCACCTCGAGAATCGAAGGTGGCGTCTGTGGCCAATTGATACGAAACAGCGTGTGTCGGGTTGGCTCCGGGAAGGAGGTCGAGCGGCGCGCGCGTGCGAGTGCGTCCAGTGGGACGCGTTGAAGGTCTTCGCGATCGTTGTCGGCGATGTACGCGACGCCTTGCGTCTCGTCGTAGCCGACTACAACGATGTCGTGGCGGCTCATGCGCAACTGGACCCGCAGGTAGGGGAGTTCTGCGATCTCCGCCCAGACCAGTGCAGGGCGTCCCTGATCGATCTCGCCACGAAGGTTCTCCCAACCCTCGGCCGGGTCGTCTGTGGCAAGCACCTCGACGGTGCCGCCCAGACGGCGGGGGAGGTCGATCTCAAAATCAGGTCCTCGTCCGACTAAGTACACGGGTGGCATCAGCGCTTTTGATCGAATGTAGGTGAGGGAGAGGGCTCCGCCGAGGGCAAAGACGAGGCCCTCGTCGGGTGGGCCGTCGTAACCGAGCCCGGTCCACTCCATGAGGTCTCGCATCGCACCGGACCCACAGTGGCCACCCATTCGGTGCGGGTAGGGGTCGATCATCGAGGGGCCGGACACTGACACGATCCTCCTGTGTTGAGGCGGTACGAAAATTGTCGATTGCCGGGCCGACGACTGAGGCAGACCGGGTTAGGCGTGGAATGCATCTAGTGACGTCGCACGCTGCGTGAGTATAAGAGGGCCATAGGCCTCTTTGAGAGCCACCAGGATGTTGTCGAGAGGCAGGTCGTTGTACACACCTCTTTCGCGGACGTACTCCATGTGTGTTGAGCCGTCCGCGGAGTGAGCGTGGAGCAACGCGTCGCTGTCGCCGGTGAAGTCGATCGGGGCGACTCCGAACCGCGCGCACAGTTCCGAGTTGAACGCGGGTGTCGCCTTGAGCCACCGTCCGTCTATGTAGACGTGGCTGTACCCGTGATAGACGAAGACGTCGGTTCCCATCAGCTCACGTAGGGCGCCCGTTTGGAGGTGATTACGGACGTCGGCGAAGCCTAGCCGCGCTGGGATCCCGGCGGCGCGGAATGCGGCGGTAAGCACGACGGCCTTGGGGACGCAGTATCCACGCCCGGATTCGATTACATGGCTGGCCCGGTAGTGCTCTGGGTCGTTGGAGACGGTGTACGGGTCGTAGCGGATGGCGTCGCGCACCGCGGTGAACAGGCGGCCGGCTTTGTCTTTGTCGGTGGTCGCGTTGCCGACGGCTTCGCGTGTGAAGGTTGCGACGGTGGCGTGCTCGATGTCGAGGAAGCGTGAACCCGTCAGCGCCGCCGGGCTGACCGCATTTGTCGGTGATGTGGTCATGGGGCCGCTCCGATCAATTCGGACCTGACGATCGGCGCTCGTTGTGCAATGGCGCGCTTGGCGGTCACGAAGTCAGCGGGTCTGTTGACGCAGTCAGCTGCAATCAGTTCTCCGGCGGTTAAGTAGTAGCAGGTGAAGTCGCGGCCATGGGCGGGGTTGCCGCTGACCAGCACCTCGTCGTATCCGGTGTTGAGCCCGGCGATCTGGAGTTTGAGGTCGTATTGGTCGGACCAGAACCATGGCAGTGCGGCGCGACCGGTTGTGTTGTCGCAGATTGTGGCCGCCGCGATCTTGGCGTGCTCGGTTGTTGCGGACACGCACTCGAGACGAACACGTCGCCCGTACCGCTCGATTCGGTGGTTGGCGCAGTCGCCGGCTGCGACGATGTCAGGATCGCTGGTACGAGCGCGGTCGTCGACGAGGATGCCGTTTTCGACGTCGATGCCCGCAGCTGCTGCGAGCTCCGTGTTCGGAATGACGCCGACGCCGACGATGACCAGGTCAGCGGCCAGCGTCTCCCCCCCGGACAGGACAACGCCGTCGACTCGTTCGTCGCCGCGGAACCCTTCGACCATTGCGTCGGTCCGTACCTCGACACCCTTCTCGCGGTGAATTCGATCGAAGAATTCCGACACGACGGGCGCCGTGACACGTTCGAGTACGCGTCCTGCCGCCTCCAGGACGGTGACCTCGACACCCAGGGTTCGAAGCGAGGCCGCTGTCTCCAGGCCGATGTACCCGCCGCCGACAATGACGACCCGCGAACCCGGGACCGCGGCGGCGCGGATGGCCTCGACATCGGTGGCGGTGCGCAGATAGTGCACGCCCGGCAGGTCGGCGCCGGGGACCGGCAGTGCGCGAGCTCGAGCGCCGGTGCACAGGGCCAACTTCGAGTAGGACACCGCGTCGTTGTTGCCAAGAGTGACGGTTCGTTCGGCACGGTCGATCGAGGTCACGGTCCCGTCGACGAGCTCGATCCGTTGCTTGTCGTAGAACTGGCGGCTCCGAATCGCGACATCGTCGAGATGGCAATCGCCAGCCAGGTATGCCTTGGACAGCGGCGGCCGCTGATACGGCAGGCGGCCCTCGTCGCCGATCAGCAGGATGGCCCCAGCCCACTTCTCCTTGCGCAAATTGGCCGCCAGCTGTGCGCCCGCGTGGCTTGCGCCGACGATCACGACCCGATCAGTACTCACGTCTCCGGCTTGGGAGTCAGACGGACCATCATCTTGCTGATCCCACGAACGAAGTTGGACTGCACGTACTCCGGATCACCGACCACCTCGATGTCGTCGAAGCGCTCGAGAAGTTCTTCCCAGAGAATGCGCAACTGCAATTCGGCCAAACGGTTTCCCATGCAACGGTGCACACCGAAACCGAACGCGATGTGGTTGCGAGCGTTGGACCGATCGATGATGAGCTCGTCCGGGCGGTCGAACACTCGCTCGTCGCGGTTGCCGGAGGCATACCACATGACGACTTTGTCACCTGCGCGGATGAACTGACCGTTGAGCATCACGTCCTTCTTGGCGACCCGACGCATGTATGCCAGCGGGGTTTGCCACCGGATAATCTCCGACACCGCATTGGGAATCAGATCCGGATTGGCTTTGAGTTTCTCGAACTGCTCGGGAAACTCGTTGAGAGCCAGCACTCCGCCGCTCATCGAGTTGCGGGTGGTGTCGTTGCCGCCGACGATCAGCAGCACGAGGTTCCCGAGGAACTCCATCGGGCTATTGTCGAGAAGGTTCTTGGTGTCCTCGTTGCTCTGCAGCATGGTGATGAGGTCGAATCCGGTCTCCTCGCCTGCCGCGGTCCGCGCGGCCTTGTCTCGCCACAGCGCACTCAAGCCCTGTGCCATCGCGACCATCTCGCGGAAAACTTTGTCGTTGTCCGATGGTCCGCCGTTGGCCTGCTCCATCGACGTGGCCAAATCCGACCACTGGACGAGTTTGTGGCGCTGCTCGTAGGGGTAGTCGAGCAATGTCGCGAGCATCCGCGCGGTCAGTTCGACCGACACGGTCTGGACCCAGTCGAACGGTTCGTCGAGCGGTAGCTCCTCGACGACTTCCCGGACGCGAGACCGGATGAGGCCCTCCATCTCGCGCAGGTTCTTCGGTGCGACGACTCCCTGGACGGCGGCGCGCTGCTTGTCGTGCCGCGGCGGGTCCATGGCGATGAACATCGCGATATCCATGAAACGCGGGGGCCGACCGATGATGATGAACGGTTCGGCGGAGAACGCTTCATGGTTTTTGTCGACAGCGATGATGTCGGCATGTCGAGTGACCGACCAGAACGGCCCGAAGGGACTGCGGGGCTGGAAGTGAACGGGCGCCTCATTGCGCACACGCTCGAAGTAGGACCGCCACATGCCCTGTCGGTAGAGAAATGGGTTGCTCAGATCGATGTCAGTGAGTTCGACGTCCTCGACCGGCGGGATGGGGGTCTCGGTGAAGATTTTCTTGCCGTCGGTTCGGGTGACGATCCGGCGGGTCTTGTCATAGACGTGAGCGCCACGGATCTGCAGATCGATCGGGATCATGGACTGCGCCTTCTCGGCGATCGCGGTGGTAATGCTCATCTGAAAGTCGCTCTCATTCTCTCACTTCACAACTGGAACTCGGGGAGGTGAACGGTCAACCCGTCCCACTCTTCGCGCGCGGTCATCTGACACGACAGCCGCGAGTTGGCCTCACGCTCGGGGTGCATGCTCAACATGCCTTCTTCGACGTCTGTGCTGTGGCCGACGGTGTCGATCCACGCGCTGTCGACGACGACGTGGCAGGTTCCGCATGCCGCCTCACCGCCACAGTCGCCATCAATGCCCGGTATCGCCTGGTCGACCGCGGTCTGCATCAGTGACCTGCCGGGCATCACCGGCGCGGGGTAGTCCTCGCCGTCGTGGGTCACGTAGGTGATCGTGGCCATGGCCACCTCCTTGTTCCTGGGTCGTAGAGATGAGTGTGCGCGCGGCGAATGTGGTCGATCCAGGTTCGGACGTCGCGATGTCTTGTTAACTTGGCTCATATGAGCCTTGTCGAGTCGGGGATGCCGCCGCTGGCGTTCGCCCAGCTCCTCGACAGCGGCGCCTTGGGCGCGGCGGAGACCCGAGCGTTCGAACGCATCATGGCCCGCGAGGGCGTCGATCTCGCGGTCGTCATTGCGCGACAGGGCCAAGTGCCTGTCCGGTGGTTTCACGAGGTGTATCCGGCGATGGATTCCCAGCAGGGATTCCGGTTGGGCGTAGCGTTCGCCGAGCACGCTCAGCTCACCTCGTTCGGCCCCATCAGTTTGCCGCTGGTCAGTGCGGGTTCCGTCGTCGAAGTTGTTCAACTGCTTCAGTTCTTGCCCCTGATATCGACCGCGCTGAGCACCGAGTTCCAGCACGGAGATTCTGGACTGACGATCGCTCTGGCCGGGCGCACCGACAGCGCCGGCACCGATTGTTTCGCCGTCACCTACGGTGGTCTGGCTGTCCTGCGGTTGGTGGACATGCTCGCCGGTGCCGTCCCCTCCGTGGAGCTTCATCTGACATGCCAGGCGCCGGCAGACCTGATCGCCGTGGGTGAGATCGGCCATCGGATCGTTTTCAACGCGCCCGCGGCGTTCGTGCACATACCGGCTGCCGTGCTCTACGACGTGTGCCGTTTCTCCGACCCCGTGGCCTACCGGATCGGTATTGCCGAGCTTCGACGCGTCTACGAACAGCGTAGGCCCAGTTCCTACACGCAGCTGGTCCGCGCACAGTTCGATGCCGACCCTGCCCGCGCTGACGGTGCTCGTATCGCGGCGGAGCTGTCGATATCGGTGAGCACACTCAAGCGACGCCTGAACGCCGAGGGCACCACCCTGCGTCGCCTGCGGCAGCAGTTCGTCCAAGAACGGGCCACCGCGCGACTGCTGGATCCGGGCATCGGTGTCGGCGAGATAGCCGCAGAACTGGGGTACTCCGACGCCGCCAGCTTCTCTCATGCGTTCACACGGTGGGTCGGATGCTCCCCGACGCGGTTTCGCCGCGCACCGGCGAATCGGCAGGCAGCGCCGGGCATCTGAGCAGGTCAGTCCGCGCGAAGAAGATTGACGAAAAAGCTGTCTACCGTGGAGGTGTCGGCGTAGCGCGCGAAGTGCATGAGATCGACTTTCACGAACTCGCCGGTGGCGGAAAAGTAGGTCTCGCCGTCCACAGTCCCGCTCGCCCCGATGTGCAGGATGTGATCGGCGTCCTCGTCGATGCACGCCGTAAGACGTACTGGTACGTGGAGGGGTACCGGTCGGCGGTACTTGACGGTCAACGTGCGCGTGACGGCCGGGGTGCCGGCGATCCACAGCGTGAATCCCATGATGTCGTCGCACGCGGCCGAGATAGCGCCTCCGTGCGCCAAACCTGGTCCACCGGAATGCTTGGTGGTGAAAGAGTGATCGGCAAAAACGCGGTCGCCGTCGCGGTACACCTCGAGCTGCAGGCCGCTGGCATTCTCCGGCCCGCAGCCCATGCACGATGGGGAGTGTGCGGGCAGTTTGGTGGGTGCTGACATCACAGTCCTCGAATCGATGCTCGTGCCGGTAGCAGACCACTACCAACGGTATCGTTGGTAGAATGCCACATCCACGCTGGACCAACAGCGTGAGGAGACCTGGTGGCGGTGAGCATCAATGGCCTCGACGACGTCGATCCGCGGCGGGTTCGTTCCCGGAACCGTCTGCTCGACGCCACGGCGGTGTTGCTGCGCAGCGGGGGAGTGGAGGCTGTCACCGTCGAGGCGGTCACGAGCGTTCCCGCAGCTGGAGACAGTCGTGCGGCAGCAGTCGGTCGACCCGATCCCTGCGGGAGTGCCGTCGTTTCAGTCATTCGACCGGATGGGCACGGCGTTCGGGGAGAAAGGCGCCAAGACAACGGCGTTTATCGCCATGGAGAACCGTGGCGGCCTCACCCCGACGGTGCGTGCACGCTACGACGAGCTTGTCCAGGAACTTCGTGGCACCACCGCCGATGTCGCTTCCGCCCGCGACCTGGTGGGGGGATCGCCGATGTGTGTTGTCGAACTTGTCAGGATGTAAAGCCTGGGACGGGATCACGGTCGTTCTAGAAGTACTGGCCGACGTCGGCAATCTTGTAGGCCACCGGGTCATGCAGGCTGTGCGTCCGGATGTTGCGCCAGAACCGGTCCAGCCCCAAACGCGGGTGTGTCCCACGCGCCCCGATGACCTCGAAGATCCGGCTGCCTATAGACAGACCCGCCTCGGTGGCCAAGACCTTCACCCCCGACACCTGAACCATCAGCGAGGCCCGATCGGCGGGTGCCAAAGCATCACCCTTCTCCCAGATCCGCTGCACCGCGTGCGACGCATCGCGGGCCGCCGCGTCAGCGCCTTGTAGTTTAATCGCAAGCTCTCCAAAGGTCCGAACTACGTATGGATCCTGCGTGGCCTCAGAAACCCCCGCAGGGGTCCATGGCCGTGCGTGCTCCAGCGTGTATTCGCGAGCGGAGTCCAGCGCTTCGGCGGCAATTCCTATGTAGACGTGCGAGAAGATCAGTTGCACCAACGGGCCGAATAGGCTGGCGCGCCTATAGCCGAAAAAGTCGGTGATCACGCTGTTCGGAGCCCCCAACACCTCGTGCGGAAGCACTTGAACATCTTTGAAGTCCGTTGTACCGCTGTCGGTCCGCCGCATCCCCAGGGCTTTCCAGTCATTGTTGGGACGCACTCCCCCTCGGTCGGTGGGTATGACCGCTGTGATAATTCCCGACCGCTCGGGTGAGTCATCATCCTGCGCCACGCCAAACACCAGAAGCAGATCGGATCCGAGCGCCCCGCTACAGAAATGCTTGGTCCCGTTCAGCACGTAACCACCGTCGTCGCGTGGGGTTGCACGCACCTTCCAGTCGAGAATGTGACTGTTGTTCTCGCTCAACGCGTTCCCCGTCCAGGAACCCTGCGCCACGCGGCGGTAAGTGGCGTCGCGCTGCTCCGGCGAGCCGAGGAGTTCGATGAAGGCTGCACACACGAGGTGGTATCCGTAGAGGTGGCCAAGCGAGCCGTCGACCTTGGCAATCTCGCGGATTACTGCGAAGACTGAATCGCCCCGGGTTTGCTGGAGGCTCGGTTAGTTGGTTCCAGCGTTTGCGGGGACCGGGTTCTCACGGTAGCTGGTGACGGTGTGGGTCGACCAGTAGGCGCTCTCGTACTCGACGGGTGGGACGTGTCCGATCTCGCCGTGCAGGCGGCGGTGGTTGAACCATTCGACGTACTCAGCGACGGCGATCTCGACCTCGCCCACACCTGCCCAGCCGCCTCGCGGGCGCATCACGGGGTTACGGATGCATTCGGCTTTGAACAGCGAGTTGAACGCCTCAGCCATCGCGTTGTCGTATGAATCCCCCTTGGAGCCAACAGATGTCACCGCTTCGGCTTCGGCCAGTCGTTCGGTGTAGCGGATGGCTCGGTATTGGGCGCGTTCAATCGGTCGATGCAACACTGGGTTGTTGTAGCGAGTGTAGTTGTTCGCCAAAGACTTCGGCGGGAGTTTTCCATCCAAGGACTTTTCTAGGACGGTTGTTGAGGGTGTAGGCGATGGCCTCGAGGTCCTCAGCTGACCACCGCGACAGATCAGTTCCCTTAGGAAAATATTGGCGCAGAACACCATTGGTGTTCTCGTTGGATGGTCGCTGCCACGGTGAGTGCGGATCGGCGAAGAACACCTGCGTTCCGGTGTCCATCGCGAACTGGGCGTGAGCGGACAGTTCCTTGCCGCGATCCCACGTCAACGTTTTGCGCAACTGCTGCGGCAGCGCGGCGATCGACGCTGTCAGTCCTGCATTCATCGCGATGGCACCGTAGCCACCGAGTGCGGGCCCGTTCTTCACAGGCGGCTGCTCACCCCAGCCCTGCTGGCGTGGCAGATGCACCAGAAGTGTTGCACGACTACGACGTTCAACGATCGTGCCGATCGCCGATCTCCCAGTTCCGATAATCAGATCACCCTCCCAGTGCCCGGGGACGGCACGGTCCTCGGCCTCGGCAGGGCGCTGACTGAACACGACATCGGAGGTGACGTGACCCTGCGGCTTGTTGCGCGAGCGGGCCCGCGGCTCCCTCAGTGCACGTCCGGTGCGCAGGCACGCGACCAGCTCACGTTTGAGCGCGCCGCGGCCCTCGATGAACAGGGACTGGTAGATCGCCTCGTGACTGATACGCATGGATTCATCATCGGGGAAGTCGACCTTCAAACGCTGGGAGATCTGCTCTGGACTCCACGCCAGCGACCACCGCCGGTTGGCCCGGTGCGGTTTGTTAAGCCCCTTCCATGGCGGTGGCGTGGGGCCCGCAGCGATCGTGCCATCGGGACGGCGGACAACGCCGGCCAGGCGGTCCTGTACGTACTCCCGCAACTCGACGTGGGCCACGAGCTTCGCTGTTTTCGGGCGCTTGGCGGCCTGCTGGGCTTTCCACTGCGCCACCAACGCCCGATACTCGAGCTTCCCGCTCCTGGTTGCGGCGTTGCGCCGTAGCTCACGCGAGATCGTGGCCGGACTCCGCCCGATCCACCGTGCGATCTCACGCACCCCACGATCCTGGGCGCGTAGCAGCGCGATCTCTTCCCGTTCGGCGAAGGATAGATAGCGGCCCGAAGGCTCATCCAGACTCAGCGGCCTCATGCCGCCAGCGTGGCGGAACCAGCGTGTACCCACCGGCACCGACACACCGACAGCGATCGATGCCTGTGCCGTGCTCACCCCCGTCGCGACCACCCGCCAAAACTCACGTTGCACCTGCCGCGACGGCTCCGGCCGCCCCGGCGATCGCATCGCCGGCCGAAGTGCACGATCAGCACGCCACTGCCGACGAACACCTACCGCCACATCGCTGGTCCTCCGACTCCAGTCCGCCGTAGCCACCGCAAACACCTCCATGATCATGGTGTTGCGACGACCAGTTGAATCCGCCTTGCACTCCGCGGTCGGAGTGGTGGATCAGCCCGGCCACGTCGTGGCCGGCACGCGACCGTGCCCACAATCCCATGTTCAGGGCGTCGAGGGCGAGGTCGGTGTGCATGGTGGTCGAGACCTGCCAGCCGACGACCATCCGCGAGAACACGTCCAGGACGAACGCCGCGTACACCCAGCCCGAGTGGGTGCGGATGTAGGTCAGGTCCGCCACCCACAACGCGTTCGGTGCCGCCGCGGTGAACTGACGGTTGACCCGGTCAGCCGGCCGGGGTGTTTCAGCTCCCTCGCTGCGCGTGGTCTTGCGTGTCTTGAGTCTCGCTATCCCTTGCAGCCCATCGGCTTTCATCAATCGCTCGACGGTGCAGCGGGCAGCACTATGGCCCTGTCTGCGCAATTGGGCATGCACCTTGCGGGCACCGTAGACGCCGAGGTTGTCGGCATGCACCGCGCGGACCTGGGTAAGGAGCTCCCGGTCACGCACCACACGAGGCGCCTCGGTCTTCTGGGGGCTCAGGTGGGCTCGTACCGTGGACGGAGCGATCTGGGCGGACGTATCGCGCAATGCCGCACAGATCGGATCGACTCCGTGTTCATCGCGGTGAGCCGCGACGAACTCCACGATCAGCGCTGTGGGCGGTCGATCTCCGCCGCAAAGAAAGCCGAAGCCTGCTTCAAGATCGTGTTCGCTCGCCGCAGTTCACGGTTCTCCCGCTCCAACGCCGCGATGCGGTCAGCGTCCTCACTCGTGGTGCCCGGGCGGACCCCGCCGTCGATCTCGGCCTGACGAACCCAATTGCGCAACGCCTCGGGATGGACTCCGAGCTGATCGGCGATCCGCTTGATCGCACCTCTCGACGAATCGGGATCTCGTCGCGCTTCACATGCCATCCGGGTGGCCCGGTCCTTGAGTTCCTCACTGTACTTGCGTGGTGCTGCCATGCTCTCCATCCTTCACAGGTTCGAGAGCCTCCGACAGACCCGGGGCGGTTCAGACCGTCGGCCAATCTGCGCCCCAACCACCGTGCTCCTCGGGTACCGCGAGCGCCAGCAGACCACTTAGGCGTAAGTCCTCTTTCTCACGGGTGGCTGGCCCCCCATCGCGATCCCGTTCGACGATTCCCTCCCGCCAGCTTGCAGCAAGGTCTCGAGCCACCGCGAGAGGATCGCCCGCCCGCCGGTCGGTGGCCGCCGCCGTGTCGTCGGTGACTGTCATTCGTATTCTCCAATCGCTGATGTGCCGGCCGCGCATGTACGCAGGCTCGTCTGCAGAAATTCCGGGGCCGACCAATCAGTCAGGTCGATCGCCTTATCCACCAGATCGTGGTCGACCAGGTACCGCTGTGTCGCAGCAAGGACAGTGAGCGCATCGTGGTCGAGGGTGGGTACTAAGTTGTCGGTGAAGTGCTCGCCGAAACCGCGTGTCACCGCAGTCTCGCTAACACCGAGGTTGCGGGCATGAATCGCGACTGTCTCGGTCAGATGATCGCGCGCCCAGGAGCCTGCCCGGACCACCGTATCCACCAGATGCTGCACGAGTGACGGGTTCTTATCGACGAGTTGCGCGCTGATTGTCCAAACGCTGGCGTAGTGGCTTGTCCTGTCCAAGCTCAGGTCACGCAGCGGTCTAACACCGGTGAGGTCTTCGAACTCCGCGGACCACGGAAGCCAGCTGAATAGCGCATCGACCGTCCCCCCGGCAAAGACTTGTGCCTGATGGGCCCCGACGGCGGGAAAGAGGTCCGAACCGTTCACTGATGCCGATGCGCTGAGTCGGTCCTGCGGTAAGTCGACTCCCGCCGTCTCAATGGGTACGAGCTCGATATCGTTTACTGTTACGCCGGAGTGACGAAGGGTGTGCTGCAGGGCTCGCGCCTCCCAAGTGCCCAGTGCGACGAGAGTCTGGCGCCACGGGTCGAGCTGTCGGTAGTCACCAAGGTCGCCGCGCAGGATCCGGATTGCCGATGCGGATACGCCGACACGATGCCCCGCCAGTTGCTCCGGTGCGGTCAGGGTGGGGTCGGCCGCGTAAAAGCCCAGCTTTCCCTCGAACAGGGTGACGCCCAGGAGGCGTGTGCGACCCGGTGCACGCAGGCCCTCACTCACCAACGGCGGGATCTCTCCGCCGAATCGGGTGTAAGCGGGATGATCGTAGGTGAAGTGCAAGGAGCCCAGCGGCCCTCCCAGCACGTCCAGATTGATGCCAGCCTCGGCGAGCAACTGCGACTCGCGGCCAACCAGCAGGGCGTTGGGAACAGGGCAGTTGCTGTACGCGAGGGTGTGGACCGCTGAGCTGGTGTCGGTCACAGCGCCGCCGCCCCGCTTGGCAGTTCCAGGCCGAGGTGGTCGCGCAGCGTTGATCCCTCATACTCGTCGCGGAATACCCCACGTTCTTGCAACAGCGGCACCACCTGGTCGACAAAGTCCTCGTAAACGCCGGGCAGATAGGCGGCGGAGATGATGAACCCATCAGCCGCTCTCGCATCGAAGTACTCGACCAGTCTGTCGGCGATCTGGGTGGGCGTTCCTCCCCACTGCGGGACAAAACCCACGTTCGTGCCATAACGCTTTCCAAGGTCGGCCAGTGTCAGATCCTCGCCGTCGCTCGCAACCGTGGAGAACATGTGGAGCATGGTGGGGATGTGCGCGTCCCCCAAGCTCGCGACGATGTCGGAGTACTTCGCGTCTAGGGGGAAGGCGGACAAGTCGATTCCACTATGACTCGACAACGTCGACAGACCGACCTCGGGGTGGACGAGACCGTTGATGTATTCGAGGCGATCGCGTGCGATCGCCTCGGTCTCCCCAAGTATGGGCATGACAGCTGTGAAAACCTTCGTGGCGTCGGGGTTGCGACCCGCGGCACTCACTTGCCCCTTGATGTCCTGGTACGTGCGCTGCATCATCTCCAGCGTCGGCGAGATGCTGAACACGGCGTCGGCCCACTGGCCCGCGAAACGTCTACCGCGAGGCGACAATCCGGCCTGGAGGAGTACTGGCTCGCGCTGACTTGAAGGGGGGATTTGCAGGGGGCCGCGCACGTCGAACCAGTCACCACGGTGATCGACGTAATGAACTTTCTTAGGATCAGCGAACCGGCCGCAGATCTTGTCCAACAGCAGCGCATCATCGTCCCACGAGTTCCACAGCTTACGTACGACCTCGACGAACTCGTCCGCGCGGTCGTAACGGGTGTCGTGTTCAAGATGAGCATCGATTCCGAAGTTCTTTGCCTCTGAATCGTTCAGCGATGTCACGATGTTCCACGACACCCGCCCGTCGGACAGGTTATCCAGCGTTGCCAGGATACGGGCGACGTGAAACGGCGGGTAATACGTGGTGGAGATGGTGGCTCCAAGTCCCAACCGGTCGGTCACGGCGGCCATCGTCGCCACCACCGTGGCGGGCTCGAGTGCGATCGCGCCCTGGCCGCCCAGTCCGACGCCTGTTTGCAGATCATGGCCGTAGCTGTCCTCGACTGCGAGAGCATCCGGAAGGAAAAGAAGATCAAACTTTCCGCGTTCAAGGGTCTGAGCGATCTTCTTATAGTATGCACCGGAAAGAAAATCGTTAGTTGCTGCGGATCTAGTGTCCTGAGTCATTAATTTCCGTTCGGTTGTTAGGCTAGGGAATGGCAACCCGGGGTCCGCGAGCAGTGGATATTGTTCTGACTGATGACGAGCGCCGTGAGCTCGAAGGGTGGGCGCGTCGGCGAACGACGGCCTCGGGTTTGGCGATGCGCTCACGAATCGTTCTCGCCGCCGCTGATGGCGGTTCGAATACTGAAGTGGCACAACGACTCGGCCTCAATCGCAGTACCGTGCGGCGCTGGCGAGGCCGGTTCGTCGAGCACCGCTGCGAGGGGTTGCTCGACGAACCCCGGCCTGGGCGACCTCGCACCGTCGACGACGAGCAGATCAAAAACTTGATCACCGCGACTCTCGAGACCACTCCGAAGAATGCGACACACTGGTCGACGCGGGCGATGGCCGAGCATCTCGACATGTCACAGTCAACCGTGTCGCGTGTGTGGCGGGCGTTCGGATTGGCTCCGCACAAACAGGATTCGTGGAAGCTGTCGAGAGATCCCTTGTTCACCGAGAAGGTCCGTGAATCACCCCTGGTTTGATGCCGCTTCCTTCTGAGTCAGGAAGGATGAGCACATGCCTAAGAAGATCGATCCGGAGGTCCGTTCGAGGGCCTTGCGTTTGCTGGAGGCGCACGGCGGCGAGTACACGTCGTTGACTGCCGCGGCAGAGGCGATCGCCAAGCAGGTCGGTGTCGGTGGGGAGACGGTACGTCGGTGGGCCGTGCAGGCCCAGGTCGATGCCGGCGCCCGGTCGGGGACCACGTCGAAGGAGTCCGCTGAGATCAAGCGACTCAAGGCGGAGAACAAGCAATTGCGAGAGGACGTTGCCATTTTGAAAGCGGCGACGACTTTCTTCGCGGGGGAACTCGACCGCCGCAACCGATGATCGTGGCGTTCATAGATCAGATGCGCGCCAACGGTTTTGCGGTCGAGTCGATCTGTCGGGTCTTGCGTGAGCAGGGCTGCATGATTGCCGCACGAACCTACCGGGCATCGCGAACACGCACGCCTGCCGCTCGGACCGTCTCCGATGCCCACGTCGTCGATGCGGTGCGCACCGTGGTCTGGCGCACCGATGACGACGGCCGGCGGAAGATGACTCCGGAGGGCCTCTACGGGCGGGTGAAGATGCGCGCCCATCTGCATCGGACAACACTGCCCGGGGTGTCCTATGGCGCCGTTGATCGAGCGATGAAAGTGCTAGGCCACAACGGGATTCGAAGGTCCAAGGGAGTCCGTACGACCGTGCGGTCCGCTGATGGTGTACGTGCGGAGGATCTGGTGAATCGACAGTTCAGTGCCGTCGAGCCGAACCGGGTGTGGGTGACCGATTTCACCTACTGCCGGACGTGGGCGGGGTGGGTGTACGTGGTGTTCATCATCGACGTGTTCTCACGTCGGATCGTGGCGTGGCACGCCTCGACGTCGAAGACGGTGGAGCTGGTGACGGTCCCGCTTCGGATGGCGCTGTGGCAGCGGAAACGAGAGGGTCATCCGGTGAAAGCTGCTGAGCTGATTCATCATTCGGATGCTGGAAGTCAGGGCGGATTCAACTGGTCGTCGCAACACCATGATCATGGAGGTGTTTGCGGTGGCTACGGCGGACTGGAGTCGGAGGACCAGCGATGTGGCGGTAGGTGTTCGTCGGCAGTGGCGTGCTGATCGTGCACTTCGGCCGGCGATGCGATCGCCGGGGCGGCCGGAGCCGTCGCGGCAGGTGCAACGTGAGTTTTGGCGGGTGGTCGCGACGGGGGTGAGCACGGCACAGGCATCGATCGCTGTCGGTGTGTCGGTGCCGGTGGGTACACGCTGGTTCCGCCACGCTGGCGGCATGAGGCCGCTGAGTCTGGATGAGCCTTCGGGCCGCTATCTATCCTTCGCCGAACGGGAAGAGATCGCGCTGCTACGCGCCCAGGATCGTGGGGTGCGTGAGATCGCACGGTGGATCGGGCGGAGTCCGGCCACGATCTCGCGTGAGCTACGGCGCAACGCCGCAACCAGGAGCGGGAAGCTCGAGTATCGGGCGTTGGTGGCGCAGTGGAAAGCCCAGCAGGCCGCCAAGCGCCCGAAAACAGCGAAGCTCGTGGCCCACGTCGAGTTGCGGGAGTACGTACAGGACCGCCTGGCCGGCGTTGTCCGCCGTCCCGATGGCACGATCGCTGCGGGCCCCACGCCACCGCCATGGAAGGGGCTTAACAAACCGCACCGGGCCAACCGGCGGTGGTCGCTGGCGTGGAGTCCAGAGCAGATCTCCCAGCGTTTGAAGGTCGACTTCCCCGATGATGAATCCATGCGTATCAGTCACGAGGCGATCTACCAGTCCCTGTTCATCGAGGGCCGCGGCGCGCTCAAACGTGAGCTGGTCGCGTGCCTGCGCACCGGACGTGCACTGAGGGAGCCGCGGGCCCGCTCGCGCAACAAGCCGCAGGGTCACGTCACCTCCGATGTCGTGTTCAGTCAGCGCCCTGCCGAGGCCGAGGACCGTGCCGTCCCCGGGCACTGGGAGGGTGATCTGATTATCGGAACTGGGAGATCGGCGATCGGCACGATCGTTGAACGTCGTAGTCGTGCAACACTTCTGGTGCATCTGCCACGCCAGCAGGGCTGGGGTGAGCAGCCGCCTGTGAAGAACGGGCCCGCACTCGGTGGCTACGGTGCCATCGCGATGAATGCAGGACTGACAGCGTCGATCGCCGCGCTGCCGCAGCAGTTGCGCAAAACGTTGACGTGGGATCGCGGCAAGGAACTGTCCGCTCACGCCCAGTTCGCGATGGACACCGGAACGCAGGTGTTCTTCGCCGATCCGCACTCACCGTGGCAGCGACCATCCAACGAGAACACCAATGGTGTTCTGCGCCAATATTTTCCTAAGGGAACTGATCTGTCGCGGTGGTCAGCTGAGGACCTCGAGGCCATCGCCTACACCCTCAACAACCGTCCTAGAAAAGTCCTTGGATGGAAAACTCCCGCCGAAGTCTTTGGCGAACAACTACACTCGCTACAACAACCCAGTGTTGCATCGACCGATTGAACGCGCCCAGTACACATCGGTTACACTGACTGAGCGGCTGCGGCTCGAAGACATCGCCGCGTCGATCGGGTCGGTCGGAGACGCCTACGACAACGCTCTGGCCGAGTCGGTGAACGGGCTGTACAAGACCGAGTGCATCCGGACCACGATCTTCCACTCCGGCCCGTACCGGACGATCTCCGACGTCGAGTTCGCGACCGCTGGTTGGGTCGACTGGTACAACAACAGCAGGCTGCACTCGAGTATCGGCCAGATTCCCCCGACCGAGTTCGAAACGCTCCACTACGCTGGCCTCGGCCCCGAGGACCAGCCCACACTGGAGGCGGCACAAAACCCTAGGGTGATTCACCCAGCCGATCTTTCCCATGCTCCCGGGCACCCCGCAACGGGCCAGCCACGACTATGTGCGCAACGGCACCTCCAGTCTGTACGCGGCGTTGGACATCGCGTCGGGAAAAGTGATCGGTTCGCTTCACTCACGGCATCGGGCAACAGAATTCATCGGGTTTCTCCGCAAGATCGACGCCGAGGTGCCCGACGAGCTCGACGTCCACCTGGTCATGGACAACGCCTCTACCCACAAGACGCCCGCGGTCAAACGATGGCTGACCTCGCACCCACGATTCGTTGTCCACTTCACCCCGACGAGCTCATCCTGGATGAACCTCGTCGAACGCTGGTTCGCCGAACTGACCACCAAGAAGCTCCAACGCTCCACCCACCGCACCGTGAGAGCGCTCAACGCCGACATCAGAGCATGGATCGAGACCTGGAACGACAACCCCCGCCCCTACGTGTGGGTCAAGACCGCTGACCAGATCCTCGACTCCATCGCCCACTACTGCACACGAATTAATGACTCAGAACACTAGCGGGAATTATGTCATAACGTAGGTTATCGGCGAATCTTGGAGAAAATCAGGTCATTTCGTCATCAATGACGAAACTGTGGAGCAATCACGAACCGTTCGGCCGTCGAGGCGTTCTCCAAGCTGATCCTGCGGAACGAGTACACCCTCTCCGACGTCGAGAAGGTCATCGCCGGGGACACCGATGCCGTCGACGTGCCACCCGACTAGACCCCGTCCAGCGGTGGGCCGCGACCTCTCACGGTCGCGGCCCAGCGCCCCGGCCCCGCTCACACCCGCCACCTCGAGGAACCATCGTGACCATCACCGCCGAACTTTTCCCCCGCTGCGCCCTGCCCGGCTGCGCGATCCCCACCGACACCCAGGGCCACCCCTGCAGACAATGCCGCCGTGACCTCGGAACCCTCGTGCGCCACAACCCCGGCGGCCGCCGACGCCCAAACCGGCCGCGACCACGACGTCGCCCTGGCCTACCGGGCTTAAGAACAGCTACGCATCGCCGACGCCGCCGAACAACGCATCGCCCTCCAGATCGGTCAGCGCGAGAAGCCCGGACAGTCCAGTTGGCTGTGCGAGAAACGCCGAAGGTGTGACATTCTGTCCGTTCCGTACCCGAGGAGTGCGAACGTTCTGTAGGTATCGCGCGACGGGCGGTGCGACCACCATGGATGCACTGCGCATCGTCGCGCGCCATGCCCGAACGCACCCCGCCCAATCGGGGGCCGACACTTCCTGGACGGACTCCATGACCGCACTCGACGCCGCGACCCCGTCGGCACCCGGACCGGGCCATTCGGGCCCGCAGGCCGAGGCCGAACTCGAACTGATCCCCGAGTCCGCGAAGACCCATGACGTGCGCGGACAGTTCTGGATCTGGGCCGGTGCGAACATCGCGCCGATCAACTGGGTGCTGGGTGCACTCGGCGTCACGATGGGCCTCGGGCTGTGGGAGACGGTGGCGGTCCTCGTCGTCGGCAATGCCATCGGCATGACCATCTTCGGCGTCTTCGTCGTCATCGGTCAGCGCACCGGGGTCACCGGAATGGTGCTGTCGCGAGCCGTCTTCGGACGCCGCGGCGCCTACGTTCCCGCCGCCGTCCAGGCCCTGGTCTGCATGGGCTGGTGCGCGGTCAACACCTGGATCGTTCTCGACTTGGTGATGGCGCTGCTCGGCGAGATGGGACTCGTCGACCCGGACCTCGACAACAACGCCGCACGGATCGTCGTGGCCGCGGTCATCATGGGGATGCAGGTGACGATCGCGTGGTTCGGGTACCGGGTGATCTCCGCGTTCGAACGATGGACGGTGCCTCCGACGGTCGCGATCCTGCTCGTCATGACCGTCGTCGCGTGGGTCGGCCTCGACGTCGACTGGGGACAGACGACCGCTCCGGGGCTCACGGGATCGGCCCACATCGGAGCGATCACGGCGGTGATGACCGCGATCGGCATCGGCTGGGGTCTGACGTGGATCGGTTACGCCGGCGACTACTCGCGCTTCGTGTCCCGGGACGTCCCGTCGCGCAGGCTGTTTCTCGCCAGTGCACTCGGGCAGTTCATCCCGGTCGTCTGGCTCGGCGTGCTGGGTGCGTCCCTGGCGACATTGAGCGACTCCGCCGACCCGGGTGAGATCATCGTCGACGCCTACGGCGTTCTCGCACTGCCGGTTCTGTTGCTGGTGATCCACGGACCGCTCGCGACCAACATCCTCAACATCTACACGTGCACGGTGTCGACGCAGGCGCTCGACATCCGCGTCGACCGGCGCGTGCTGAACCTGATCATCGGCGTCGTGGCGATGGCGGTCGTCGTCTACTTCGTGCTCAACAGCGACTTCGCTACCACCATCGACTTCTGGCTGGTGTCGATCGTCGGCTGGTTGAGCCCTTGGGGCAGCGTTGTTCTCGTGCACTGGTTCCTGATCGCTCGGCAACAGATCGACGCCGAGAGTCTGTTCGCCGCACCGGCGGACAGCGTCCTGCCGATGGTCCGGCCGACCGCCCTCGTCGCACTCGCTCTCGGTGTCACCGCGACCTGGATGTTCATGTACGGGATGCTGCCGGCACTGCAGGGCCCCGTCGCCGTCGCCCTCGGTGGGATCGATCTGTCGTGGCTCGCCGGGGCAGTCGTTGCCGGCACCTCCTACTGGACCATGGAGAAACTCACCGCGCCACGCGCTGCCTGAAGCCCGTCCCGCCAGAGCCGAGGCGGTCGGCGGCGACGACGGGCGAAAGCCGCCTGCCGCATCAGGTCGTCGACTAGGGTTCGGCCCAGCGGGAGGTAACGCGGCCTCCTGATGAGGAGGTTTCATGGCCACCGTCCAGACCGCAACCGGCTCGATCGATTCCGCCGACCTCGGGAACGTGTTGGTGCATGAGCACGTCTTCATCGTCAACGAGGAATTCCGGCAGAACTATCAGGACGATTGGGACGAGGACGAGAAGGTCGCCGAAGCTATCCGCGACCTGACCGAACTGAAGGAACTCGGGATCGACACGATCCTCGACCCGACGGTTCTCGGTCTCGGCCGGTACATCCCACGCATCCAGCGGATTGCCGAACAGATCGACCTCAACATCGTCGTCGCGACCGGGTTGTACACCTACAACGACATCCCGTTCCAATTCCACTACGCGGGACCGGGAATGCTCTTCGACGTCCCGGAGCCGCTGGTCACCCTGTTCACTAAGGATCTCACCGAGGGCATCGCGGACACCGGTGTGCGGGCGGCTTTCCTCAAGTGCGCCATCGAATCCCAGGGACTGACACCGGGTGTCGAGCGCGTGATGCGCGCGGTGGGACAGACCAGCGCCCAGACCGGCGCGCCCATCACCGTGCACACCGATCCGCACAGTCAGTCGGGACTGGTCGCCCAGAAGGTCCTGGCCGAGGAAGGGGCCGACCTGACGAAGGTCGTCATCGGCCACTCCGGAGACAGCGTCGACCTCGACTACCTGATGAAACTCGCCGACGCCGGTTCCGTTCTCGGCATGGATCGTTTCGGGCTCGACCTCCTCCTGCCGTTCGACGAGCGCGTGAACACGGTCGCCGAACTGTGCAAGCGCGGCTATGCCGACCGCATGGCCCTCGCGCACGACGCCGCCTGCTTCATCGACTGGTTCGACCACGAGGCCAAGAAGCAGGCACTCCCGAAGTGGAACTATCGGCACATCAGTGAAGAGGTGTTGCCGGCGCTACGGGAACGCGGGGTGAGCGAGGCCGACATCACGACGATGCTCGTCGACGTGCCGCGACGCTACTTCGAGTAGCGGCGCGACACGGCGAGAGGGTCAGCGCAGGCTGCTCTGGTACCGGCGCATCCCGCGGAGCCACCGGTCGTAGTCGGCGCCCTTCTGGCGGTACATCTCGAGGACCTCGGGGTGGGGGAGGATGAGGAAGCGTTCGTCGGCTACGGCGTCGAGCACGATCGCGGCCACCGCCCCGGGCGTGAGCACCGTGCCCGCGGTCTCCACGGCGCGCTGCATCAGTCGTTGCTCCTCGGTGGCGGAATCACCTTCCGGCCGCAGCAGTTTGGTGTCGACGCCCATCGGGCAGAGGCAGCTCACCCGGATGCCGTCGTCGCCGTGGGTGATGTTGAGCCATTCCGCGAAGCCGACCGCCGCGTGCTTGGTGACCGAGTACGGGGCGTTGCCGATCTGCGTGAGCAGACCCGCGGCCGACGCCGTGCTGACGAAGTAGCCGGTCCCTCGTTCCACCCAGTCCGGGACGAGGCGCCGAGCTGCTCGGATGTGGGCGCGGAGATTGACGTCCAGCGTGAGATCCCACACCGCCTCGGCGGTGTCGACACCGCCACCCACACCCACGCCGGCATTGGCGAAGTAGAGATCGACCGGGCCGAACGTGTTCTCCGCCAGCCGGACCGCGGCGTCGATGTGTTCGTCGGATGAGGCGTCACCGCCGATCGCGGTCGTCGAATCCCCCAGTGAGTCGGCGACGGCCAGGGCGCCGGACTCGTCGAGATCGGTGACGACGACCTTCGCGCCCGCATCGACCAGCGCATGCGCGATCGCCGCGCCGATACCCGCACCGCCACCCGTGACGATGGCCACCTTGCCTGCGACGTCCATGGATCTCCTTCGATCGCCGATGTGTGGGTCCAGAGTTACCAGACGCGAGGGCTTCGACAAGCTCAGCCGGCGGGATGGGGCTCAGCCCTTCCGCTCGCTAATCCGAAAGAAGCGACCCCCATTGCTCCCTGAGGTGTGAGGAGCGATAGCGACGAGCCTCGAAGGGGCCCGACAAGGGCACGACCCTTCTCGAAGCCGATGACTTTTCCGCCGCCCCACGGTCTGACATCGTGACGTTCACCGCGACGAGACGAGAGGCCACACCATGGGAAAGATCCACGTCCACGAGTTCATCACCCTCGACGGCAGCTACGAGGACCCGAGCTTCACGATGCCGTATGGATTCGCCGACGGGATGGGCGAGCTGCTCGGTTCCTTCATGTCCGACTGCACCGGAATACTGCTCGGACGCAACACCTTCGAGATGTTTGCCCCGGCCTGGGCGCACCGGACGGTCGACGACGATCCCGGTGCGCCGTTCTTCAACGACACCACCAAGTACGTGGTGTCCTCGACCCTCGACGACGCGGCTGCCTGGCAGAACTCGGAGATCATCGGCGCCTACGACGCCGACCGGATTCGCGAACTTAAGAAGGATCGCGACCTCTACATCAGCGGGAGCGGCACCCTCGTGCGGGCGTTGCTGCGCGACAAGCTCATCGACGAGCTGCACCTGCTGGTGTACCCCGTGGTCCTGGGGAGCGGTGCCCGCCTCTTCGACGGTCTGGCCGATCTGCCTCTCACGCTCGTCGGCACAGACGTCTTCGACAACGGCGTCGTACACCTCTCGTACAGCTCCACCGACTGAGCGGTCGCGATCCTCGGCGGAGATGGCGCCGGAGTTCGTCGAAGGCGCAGCGGCCCTTCGTGGCTCGTCGCTTGCGCTCCTCGCACCTCAGGGAGCAGAGGGGGTCGCTCCTTTCGGACTAGGGAGCAGGGGGGCGTTGCGACGGCTCCGATGCCCCGTCAGCGAGGTCCATGGCGCTGAGGAGCAGGCGGGCGACGCGGGCGTAGGCCTGGTGCTCGGCCTCGCACAGTGCGATCTCCTCGGCGCCGAGCTCGGCATTGCGGGCTGTCGTCAGATTGTCCATCCACTCGCGCATCTCGGCGGCACAGATGTCGAAGAACTCGTGCACACGCTCCCGATCCCGGTGGCACGCCGCGAGAACCGTCGTCGGGGACAGCTTGTTGTCGAGCTTCTGGTTGACCCGCAGGAGACTGAGCAGGGCGCCGGGCAACCGATCGCCGCGGCGGCGATGATCCAGTTTCGGCTGGCTGCCGAGCCGCCTGATCATGTCGCCGCGGGCCGACCTGGCGAAGTCGTCCCAGCGCCGGAGGGCGGCATCGAGGTTCGCGGGACTGAACACCGCGACGTCGATCCGGCGCTGCGCGTACACGAGTCCGTTGCGTACGACCACCGCGACTTCGGGCCATCGCGGGGAGAACTCCGCGACCACCATCCCGAGCAGCGAGGGTGCGGGCACCGACGAGCTGAGGATGGTCACGATCTCCAGCGAGCGGGCATCTCGGGTCGGTCGTAACAGCGAGGTGCCCGTCGACCGCAGGAAGATGGCCTTGCGCGGACTGACCACGGCGGGACGGCCCGCCGCGGTCATCGCGGCGCGGACCAGTTCGACGAGATGGTCTTTCGACTGCGGGATCACCCCGCCCTCCGCGGGGGCGTCGACGAATCGGGGCGGCGCGGTGAAGCGGAGTGTGTCGGCGTCGGTGATGCGGACGGTGTCGTCGGGATCCTCGCCGACCACGCGGCTCGACTCCGATGACCGGGCCTGGTCCCGCTCGGCGTCGAGATCGTCTGCGGGCAGAGGTGAGTGGTGGCGGGCGAAGGACGGGTCGCCGATGCTGACGAATGACGGATGGATGACACCCCACACCTCGCGCAGGGCCCGCACGGCGGCGTCGGCGAGGTCGGCGAACCGGAGGGGGTCGACCTCGAAACAGAAGGCGCTCCGACCTTCGAGCCGACACCAGCCGCGGTCGACGATGTAGGTGGCCTGTCGCATCCACCGGTCCTTGTCGGTCCAGGTGAGGTCACCCGCGGAGATGGTGCAGCGGAGGCGTTCGGTCGACCCGAGGGTTCCGGTCACCGCAAAGGTCATCCGTCGACGCCATCCCCCGGCGGCCGCCTCGACGATGGCGAGACTCTGACCCGGCAGGAGGCGTGGCACCCGGACCGCGAGAGTGTCGGCGAAGTCCCGCCAGGCCGCCTCGAGGACGGCGTCGAAGTCGGGGGACATGCGGGTTCCTCCTGGGCGGGACGTACGCGGACCGGATCCGAATAGTACGACGCGGAGCAGACACCCGGGGCGACACCCGCGACAGAACTAGCGGGGTGCCGAGTGCTCGACCGTCTCGTCGAAGACGGGGTGCCAGGGAAGGCTGTGCGCGGCGTAGTCGGCGCTCGTCGGCGCGGCCCGCGGCACCGGTTCACCGGTCATCGACCTCCATGCGATCGAGTTGACGATGCGGACCGTGGCGGCGTCGGAGATCGTCGGGTGCCAGGTGTCGACGGACTCGAGCGGACCCGTCACGAGCGGCGCGGCGAGGCGGGGATGCGCTCGTTCTCGTTCGGCTCGAGAGATGTCGCAGAGCACGCAGGTGCCGGGCGCTGACGGACGATGGCGTCGTCGCCGGGCCCACGCGTCGGCGCGCATCGGGATGACGGCCAGCTGCACGAGCGTCCCGAGTCGGCCGCCGTCCCCGACGGTGTGCGTCGAGGGGGCGAGGAACTGCTGATCGTCGAATCCACCGCCGGCCGGCCCCCGGTGCGAGGCGAGCGACGGTTGCGTGGGGACTTCGAGATAGTCGCCGGCGTCGAAGTCCGGCACCCCGGTGAACACCTCACCGCTGATCGCGTTGACACCGTCGACGCCGACCATCACCAGGAACGGATGCAGGTGCGGCGAGGAGAAATCCAGCCAGGTGGCCTCGGACTGCCACATCGGGATCGTCGCGTGTGCGTCCCCGTCGGGAGAGCCCTGGGCGAGGCGCAGGGCGCCGTCGCCGCCGGCCGAGCCGCATCCTCCGACCGGGTCGGGGGTCCGCAGCGTTCGCTGGAACGTGACGTGCAAGCGCGCGTCGCGACCGAGTTCGGGAAAGGTGAACGTGAGCGCGCCGCGATCAGTGGTGATGGCCATGCGAGGGCTCCGATCGGTGACGCGAACCGCTGAGGGTGGCCTAAAGAATTGAACGCCTCGCCGGCCTCCGGCGCGATGGGCGGCGTCGAAAATCGTCCGCGCAGACTACGTGCGCCGATGATTCGGATCCCGATTTGCCGGGATCACTTGGCTGATGAGCTGCTGTCCGCGGTGTCGTCGTCGGACAGCACGACGACGCGGAGAGCGGCCCGCAGGTTGTGCGTGGTCGCCTTCCAGGTGTCGGCCTCGTGACGACAGGCATCGGCCTGCACCGAGTCCGACGCGGCGGCCGCGTCGACCGCCGAGCGCCGCCACGTGAGGTGCTGTTCTTCGCTGGTGTGGATGTAGGAGAGGATGTCGGCCTGGTTGTAGCGGCAGATCTTGGCGACCTCGCGGGCGCTCAACGACCGGCCGTCCGGGTCGAGCTCGAGCAGCGTCTGCAGGGCGTCGGGGAGCCGGCCGTCGTTCCGCGCGGTCAGGGGTGTGTCCTCGCCGACCTTGGCGATGACGGACGGTGCGCAGTCGGCGAGGAACGAGAACCACTCGGCCAGGGCCGAACTGAGGTTGTGCGGGTGGAAGACCGCGCACTCGACGGTCAGCGTCGCGAAGACCTCGTTCTCGAGCAGGTGCACGCGCACCGCCGAACCCATGGTCGGCTGGGCGGCCACGATGTCGGCGGCGCGCCGGCGGTCGGTGATGTCGCCGGCCAGGCGAGCGAAGAACTCGAGCCGCGGGGCGTCACTGCGCGGACTCAACCACGACGAGACCGGCTTGGTGGGCAGGGCGATGTCACCGTCGGCGTCGGTCTGGATGCGGCAACCGGTGAGGTCTTCGAGCGAGCCGACGAGCAACGCGCGCAGATGGTCGGCGTCGAAGGGCTGGACCGCGACCTCGATCCGGGGTTCGGGGCGAGCGGCGGGGGAATGGTCGAGGAACGCGGGGTGCACGACCTCCCAGACCTGACGCAGCGTCAGCACCGTCACGTGCGCGAGCTGATCCACGCGGCGTCGGCCGACCTCGAAGATGTGGGTGCCGTTGCGCAGGCGCCGCCAGCCGAGAGAGGCGAGCATGGCCACGTGCTCGGCGAAGTACTCCGGGGTGGGATGCAGGTCGGTGTCGTCGATCGTGCAGCGCAGCCGACGTGAACCGGTGATCGTGAACCGCAGCGTCCCGTGGGGTCCCTCCGGGATCATCGGGTCCTGCTGGATCGTGAGGGTCTCGCCCGGCTCGAGATGCGACAGGCGATCGCCGACGTGCAAGGCGAACGTGCGCCAGGCGTCGTCGATGTTCGAGTCCACGGTGAAGTCGGTCATGTCGACTCCCTTCCTCGTGCGCTGACGAGCATGCGCATTGTGCAGCGATGTCGGGATCGGGAGCACGCTCCACCGAGCTGTTCGACGGCCGGCCCCGAACCCGCCTCGGAGTTCAGGTTAGGTGACCTGGCCGACAGACTTGGTCGGTTGAACAGACCCCGCGATGAACTCGTTGCCCGAACCGTACTCCAAGGTCGGTGACCCGGCTGAGTCAGGCACAGGTTGTCAACCGACAACGAGTAGTTGTGTCCCCAGCCTTGGGGACACGCACTCGGACCACCGCTCAGACGCTGAGCCGCTGATGCCAGCGCAACGTCACCGAGGTCCCGTCGGGCCCGCTGGTCACGTCGGATGCGTCGCTGAGCGCCGAGATCAATGCGAGGCCGCGCCCGCGATAGGGCGACGACGAGGCATCGGATTTCCAGCGCCCTGAGTCGGTGACCGTGACCTCCAGCGATTCGTCGCGCGTCACGTGGGCGCGAACCCCGATGGCACGGGACCGTGTGGCCGAGGACTGGGCGGCGGGGGACTGGGCGGCGGGCGAGGGCGCGTCAGCGGCGTACGCGTGCTCGGCCGCGTTGGCCACGGCCTCGTAGACCGCGAGGACGATGTCGCTGCGACGTTCGGCGTCCACGTCGAGCGTCGCGTCCAGCCACCGTGTGAAGTGCTGCCGAAAGAGGTGGGCGGACTCGGGCGTGGCTGTCACCGACAGCGTCAGGCCGCCGTCCGAGTCCTCGGGGCGCGGGTGGGCCGAGGAAATCCGGACCATCGGCGTCTAACCAGCCGGACGGTCGGCCAGCCCCTCTGTGGTGGTCATGGCCGTGACCGCGTCGTTCAGTGTCGGGTAGAGCACCATCGTCTGGTCGAGTCCCATCACGGTGAGGGGCCGTGTGGTTGCCGGACCGGCGGCCACGACCCCGAACATGCCTCTCGGCGCGATCGCCTCATGGGCGGCGACGAGCGCTGCCATGCCCGCCGAGGCGAGGAATTCGGTGGTGGTCAGGTCGATGATCAGACCGTCCGGTTGCCCGCTGAGCGCCTGGGAGACCGCCTCGGACAACTGCGGAGCGGTGAGCACGTCGATGCTGCCCTCCACGGTCAGGATCACCAGCTGCTCGTGTGCCGCGGACACCACCGTCATCAGGGCGCGTCCGGCACTCAGGCCGTTGTCGTCGACGATCACAGCGTCAGGATGTTCTGCCTGCATCGGTGGTGGCCCTCTCTACGGGGGACTACAGCAGGCCGGCGTGCGGCCCCGTCCCGGCGAAACGTATGACGGCAGTTGCTCAACCGGTGCCGTCCATCGTGCCATGGGACGCCGTCGCGCCGGTACCGGGGTGAGCGAGAGATCTACCGCGCGATGAGTGACTATTTGCCGAAGAGCCGATCGAGGAACGGGATCGTGTCGGCTTGCGACCGAACCAGTGTTCCGCTGTGGTCACTCGGATAGGTCCGGAAGGTCACGGGTTGGCCGTTGGCCGCCAGCGTCGCGGCGTACGCCGCGGTGGTGGGATACGGCACGTCGGTGTCCAGCAGGCCGTGGCCCATGAAAAACGGCTTGTCGAAACCCTTTTCGGGCATGCCGAGGTAGTCGGCGAGGGTCGCCGAGAAGTTCGGCAGGCTGGTCAGCGGAGCGGAGAAGTAGTCGCCGACGGAGACTCCCCGGAGCTGCTCCTCGAACTCGCCGACACACTGTGTCTCGGCGAGCGCCACATACTTCCGGCCGGTCGGCGTGAGGATGCGATCGATGCCGAGTTCGGGGTGTGCGTATCGGAGGCCGGCCGTGATGTAGCTGAGGTAGGCGGTCAGCGCGGGTGTGATCGCCACCGGCGGTACGCCCGGGCCGGCGATCTGGACGAGGCGTTCGATGTAGGCCGGCGTACCGGTGCCCACGGCGCCGCGGTAGTCGAGTGCGGGACCGCCGAATTGCGTGGCGTAGCGCGCGGTGTAGATCGCCGCGCCGCCGCCCTGCGACTGCCCGACCGCCGCCCAGGATCGTGACAACCGCTGTGCGGCAGGCAGACTCGCGGAGACCTCGCGACCCGCCCGCACCATGTCGACGACATTGTGGGCCGTGGTCCGGCCGTCGAGGTAGGCATGCAGGCCGGGGGTGCCCAGGCCGGCGTAATCGCTGGCGACGATGGCGTATCCCTGCTGCATCCACTTGGCCAGGTACGGCAGGTCGCGCTCCGGGAGGCCTGGTCCCCGGACCGACGGCGCGCAGTCGTCGCCGATCCCGGATGTCCCGTGGGCCCACGAGATCACCGGCCAGCCGCCGGGCGGGGCGGTGCCCTCGGGGATGAAGACGGTCCCGGTGCTCAGCGCCTTGTTCCCGAACGTGTCGGTGGTGACGTAGGTCAGGACGGTGGCGTCGGCGGACCCGGGAACCCAGAACTGCGGCGCCAGCGGGCGCGACGAGACGACCGAGCCGGTGTCGCCGAGAGTCGACGGTGAGGCGATGGCCGGACCGGCGGCGAGGGTCCCGGCCGCGCCGGAACTCCCGATCACGACGGCCGCACACGCGGCGAATGCCAGAACCTTGCGATGCCATCGAGTCACGGTCCTCACCGTACTGCGGACGAGTCCCGGTCGTCGATTCGCTCACCTATCCCGTTGCTGCGCAGCCATTTCGGTGAGCGGTACCGGATTCGGTGAGCGGGGCCGGTGGCCGCGGCAATACGCTGGGTCGGACAATCCCGACAGACAGGTGCCACGACATGGCGTTGCAGACGGTCGACCTGCCGGCTCCGGCGGAGATGCGATCCAGGTGGGCTGCCCACGCAGCTCTCCTGGCGGTACGAGGAGAACGCTGGGCGCAGGGCGCGTATGCGACGCCGGACGGGTGGCACTACGACGACGGTGGCGGCAACTGGGTCGACGTGGTGCTGGTCGGTGCCGACCGGGCGGTGCTCGTCGGCCACGATCACGAGTACTCCGAGACGTACTTCCGCGAGGGCGCCACATATTTCGGCGAGTCGGAGACCGACCTGCTCGGCGGCGCGCCGCCGTGGTGGGAACCGGCCATCGCGTCTCACCTCGAGAGGCAGCGCACCGACGGCATGTGGATCGGATTCGTCTACGGTTTCGACGGCCGATGGACCCGATCTGGTTACGACCTCGCCGACGGTTTCACCAGTGTCGGGCTGCCGTTCACCGATGACCAGAAGACCGTCGATGCGCTCGACGATCTGCTGGCGAACTGGTTCGTCGAATTGCGACTGGCGCCCCCGGCCGACATCCGTGCCCGTGTGCGAGAGATCATCGAGCCCGGGGCGGAGGTGACCGCGGCGGGTCTGCATCGGATACTCGGACCGGCGGGCGCACACGCCGACATCCCCGGGGCAGTGGCTGCGGCGCAACGGTTCTGACGATGTCAGGTCCGACGCGCCGCACGTCCGTCACTGCGAGCGCAGCTCCCGCTTGAGCAGTTTGCCGCTCTGATTGCGGGGGAGTTCGTCGACGAACCGCACCTTCTTCGGGACCTTGAACGGCGCGATCCGGGACCGGACGTGCTCGATCAATTCCTCCTCGGTCACCGACCGGCCGTCCCGCACCACGACGACCGCGGTGATGGCCTCGATCCACTTCTCGTCCGGCTCGCCGATGACGGCCACCTCCGACACCGCCTCATGGGTGTAGACGGTGTCCTCGACCTCACGTGAGGCGACCAGGATGCCGCCGGTGTTGATCACGTCCTTGATGCGGTCGACCACGGTGATGAAGCCCTCGGCATCGCGGGTGACGAGGTCGCCGGAGTGGAACCAGCCGTCTCGGAACGCCTCCTCGGTGGCCGCGGGGTTGTCCCAGTACCCGCGGCAGAGTTGCGGCGAACGATAGAGGATCTCGCCGGGGACCCCGGGCTCGACGTCGTTCCCGTCGGTGTCGACGACGCGCGTCTCGACGAAGAACACCGGGCGACCGCACGACGACGGCCGGTCTTCGTGTTCCTCCGGGCGCAGAACCGTTGCGAGCGGGCCGATCTCGGATTGCCCGAAGCAGTTGTAGAACTGCATGCCGGGGAACTGGTCGCGGAGCCGGTTCAGCACGGTCACCGGCATGATCGACGCGCCGTACTGCGCCTTGCGCAAGGAGGACAGATCGCTGGTGGCGAGGTCGGGATGATTGGCCAGCGGAACCCACACGGTCGGAGCGAGGAACAGCGAGCCGATGCGGTCGGCCTCGACGCGCCGCAGGATCTCCGGGATGTCCGGCGTGGCCATGAGTCGGACGGTCGCGCCCACGGAGAGGTACGGCAGCATGAAGACGTGCATGCCCGCCGAGTGGTAGAGCGGCATGGCGATCAGCGGATTGTCCTCGGCCGTGAAGTCCAGCGCGATGACCGACGAGACGTACTCGCTGATCAGTGCGGCGTGGGACATCATGGCGCCCTTGGGCTTCGACGTGGTCCCCGAGGTGTACAACAGCTGCGCGAGGTCGTCACCCGAGGCCCGGGAGTCGAATGCGGCGGGCGGTTCGGATGCGGCCGACGCGAGCAGCGAGTCGTCGGCGTCCCGCAACGGGACGACGGCCTCGACGTCGGCGAGATCGCCGCGGATCTCCTCGACCCGCTCGGACAGCGCGGGGTCGACGAGGACGGCGCGTGCGCCCGACTGCACCACGAGGTAGCGGAGCTCGTCACCCCGGAGCGCGTAGTTGATCGGCACGTGGACGAGTCCGGCGCGACAGCATGCCAGGAAGCCGATGACGTAGGCATCCGAGTTCGTGCCATAGGCCGCGACCCGGTCCCCCTGCTCCAGGCCGCGGGCGAGCAGGCCGGCGGCGGCAGCGGACACAGCGTCGTCGAGCTGACGATAGGTGTAGTCGCGGTCGTCGAAGACCAGCGCGGTGCGGTCGGGATGCCGCGCGGCGGACCTGCGGAGAATCCCGTCGATGCTGTTCGTGGAGGAGAGTCGCGGAGCCATGCCGACGACAATACTTGGACGTCCTAGTGACACGCGCCGATACCGCGTATCAGGGCCAGAAGATGGTGCCGTTCAGGAAGTCCTGCGCGAACCGGCCGCCGGTCCGATACTCCCCGCCGAGCGGAACCCCGAAGTACCCGCCCGCACCGCCGGTGTTCTCCCACTTCTGCCGGATCTGGCCCCACACGATCTGTGCGCCACCGGTCTTGGACCACGTGACGACGCCGCCCTGGAAGTCGTTGCTCCGCCCGCTGCCCGACCGGTACTCGTTGCTCACGGGGTAGCCCAGCGCGCCGCGCTCCGCGCCGGCCTGCTGCCATCGACTCCGGATCGCGCCGCCGACCTGATGCGCGGTGCCGCCGTCGGCTGCCGGGTGCCAGTAGAACGACGTGTCGCGCGAGAACGTCTGGAAACGGCCGCGCTTGGCGGCCACGCGTTCGGGACCGGTCGGGACGCCCCACTTGAAGAACCCGCCCGTCGAGGCGTACGCCTGCTCGATCTTCCCGCCCACCAGGTGCCCGTTGATGACGCGGTCCGCATGCGCGCTCGGCGCGAACATCACCAGCGACGCCATCGCCGCCACGATCGCGACGCTCGCCAGACGTACCCGCACTCGCCTACGGGCGGATTCCGGGCGGAGGTCACGAGAGGGGCGTCGGGTCGACGTCGTCAGAGCAGACATGCGCGCGATGGTACGGACGTCCCAGGGTGCCTGCTGTTGGACAGCTCACACCCGTGGTGCGGTCACGGAGTCCCCGCAGGTGCTTCCGGGTCGGCGGGGGCGTCGGCCGGAGGCGGGCTCTCCGTGGTCGTCGTCGTGGTCGTGTCGTCGGGGAGCTCCTCGGCAGGGGTTGCGGGATCCGCGGAGCCGTCGGATGCCGGTGGTTCGGAAGCCGGGGCCGCCGGCGGCGCGGCGATCCAGTTCGCCGATCGGACGGTCACCGATCGCGACGCGCCGACCGCCGTCAGCGTCAGGGTCCACACCCCGGTGCCGGTGGTGGAGCCCGACACCCCGGGGCGGTGCAGCGCGGAACCGGCGACCGACCGGGTCACGCCGTCGGTGCACGAGAGCGTGATGGTACCGAGTGCTGGACCGCCGGGAACCGTACAGCCCACCGACAGCCCGGCGTCGACGAAGCTGAAACTGCCGACGACCTCCCCCGATCCGCTGAACGAGGTCGGCGTCGTCGGCGTTTCGGCCGGTTGGTCGGGCCCGGGCGCGCCGGGCTCCGTCGCAGGTCCGGGGAGCTCGGAGCCCGGGGCCTCGTAGCCGGGCTCCTCCGGGACGGGTACGTCGGAAGCCGGCACCGGGGCGTCCGGGGCCGGGGAATCCGGGCCGGGACCGGGGGTGTCGGGGGCAGCCGAGTCCGGTCCCGATGAGTCGGGGGCCGAGGAGTCCGTCGACGGCGCGCCTTCCGGCAGGCCGTCGTGCTCCTCGGCACGCTTCTCCAGTGCGGGCGCGGCCGCGGGATTGCCCGCTGCGAGGAGGCCGTTGTGCTCGGCGTCTTCGTCGGTGGCCGCCTCGAACGGGGTGTTCAACGCGGCCGGGGTGGGCAGCGGACCGGACGGTGGCGGGAATCCGCTCAGGTCGAGCAACCCGCCCGCCGGTTGCGAAAAGATCTGTCCGGTGAGGAAATTCAAGAGCTGGAGAACGTCGCCGGCGGGCGCCCCGGGGTCCGGGACCGGCGGCGCGGGGACGATCGTCGTCGACTTGCCGACCGCGGTGACGTGCTGGTTGTTGTACGCGATCCGGGCGACCGACCGGCTCTTGTAGCCCTCCCACGGCTGTCCGTCGAGTCGATACCCACCGAGCGGGGCGGCGGCCGGCGGGGCGAGCGGATTCCCGCAGGAACACATCGCGCGCGGCACGCCGGCGGAATCGACGTAGACCGCGGTGCCGCGCTCCAGGACCGACTGGAACGGGACCGCCCGGCCGGAGGTGTACGAGTGATTGGTGACCCAGGTGTCGGTCGTCAGAACCACCGGGGTCAGCGTGTTCAGGTAGTGCGGGATGTCGGCGGTATCGATGCCGTAGACCCCGGCCCACGCGCGCGCCGCCGGCGGATCGGCGAGCAGCCGGTTGCTGAGCGCGGCGGTGTCGCAGGCTGCGGCGTCGCCGGAGCCGTACAGCCCGGCGTCGGTACCGTTCACCGCGCGGCCGCCGAGGTCGGCGGCCCCCGCCGTGCCGGTGAGGGCGACATTCGCCGGCAGGTCGCCCGCCCCGGCCACGAGGACCGGATCGGTGAACGGGTCGATCCCCGGATCGTTGGCCGCGGTGAGGGTGAGGCCGGGTACGAAGATGTCCCCATCGCGCGCCTTGACGACGAAGACGATGCCCGCGGCGAGGATCAGCGCCAGGACGACGACGATCGCGCCGAGCACGAGAGTGAGGGCGCGCCGGCTGTCGGACTGCGGCGGCACCGGGCCGTACGGGTTCGACGGGTGGGACGGGGGACCGGGCGGATAGGTCATCTCGGAGCTCCTACTGGTCCACTCCTGCCGGGACGCATGCCGTGGAGTGGCGCTCCGCGGGGGCGGGGCGGATTCAGCGAGACGGCTCGCTCGCCGAGCCCAGTATCGGCGCGGCGTCTCGCGAGGAGCAAGGCTTGACCAGCATATTTACGGTGCTGAGGCGAAATCTCGACCGTTTGGACCACACCGGCGTAACGCCTCGCGCGGGTCGGCCGACACCACCCCGGTCTGCGTGAGCTGAGTCAGACCCGGCCGAACACCATGGAGTCCTCGACCTTGTTGATCCGGTGGTCGATGGCGTCGCGGTAGTAGTTGTGCCGCACCTGCCAGTGACCCCGCGTGCCCGACTTCGGCAGCGCCTCCGGGGACCGTTCGACGTAACCCGCCTTGAGGTCCCACAGCGGCCGCGAACCCATGACCTCCGAACCGAGATGGGGATAGGCATGGGTGTAGCCGTTGGTGCGCATGTACTTGACCAGGTCGGCGACGGCGCGAGCGGTCATGTCCGCGCGCAGGGTCCACGACGCGTTCGTGTAGCCGACCGACCAGGCGAGGTTAGGCACGTCCTCGATGAGGTAGCTCTTGAAGACGAATCGGTCGTGGGGTTTCACCTCGGCGCCGTCGACGCGGAGCCGGGTGCCGCCGAAGCCGAGGAGTTGGAGCCCGGTCGCGGTGACGATGATGTCGGCGTCGAGGTGGCGACCCGAGGTGAGGGTGACGCCGGAGGCGTCGAACCGGTCGATGTGGTCGGTGACCATCTCGACGGTGCCCTCGGCGATGTCGGCGAACAGATCGGCGTCGGGGACCATGCACATGCGCTGATCCCACGGGTTGTAGGTGGGATTGAAGTGGAGGTCGACCGGATAGTCCTCGGGCAGGTTCGCCACGACGTTGCTCCGGATCATCTTGCGCCCGAGCTTCGGGAACCGATGGGTGAGGTGCACGATCGCCGCGGTCTGCGCCGCATATCGGGTGCGGATGACCTTGTGCGCGGCGTGGGGCGGCAGCAGCTTCTGCACGAGTGGCGCGAGGTATTGCTTCTGCTTGGACGAGAAGATGTACGACGGCGAGCGTTGGAGCATGGTGACGTGCTCGGCCTGCTCGGCGAGGCTCGGGATGAGGCTCACCGCCGTCGCGCCACTGCCGATCACCACGATCTTCTTGCCTCGGTAGTCGAGGTCCTCCGGCCAGTGCTGCGGGTGCACGATCTGACCGGTGAAGTCGTCGGCACCGGCGAACCTCGGCGTGTACGGGTTGTCGTAGTCGTAGTAGCCGGTCGCGAAGATGACGAACCTGGCGCGGTATGTCTCGCGGCGCCGGTCCTCGCCGACCTCGACCCCGAGCGTCCAGGTGTCGGTCGTCGAATCCCAGTCGGCGGTCAGGACATGCTGACCGAACCTGATGTGGTCGGTGATCGAGTACTTGGCGGCGGTGTCCTCGATGTACTCCCGGATGTCGGTCCCGTGGGCCAACGCGCGCGGCTTGCGCCACGGCTCGAACGGGTAGCTCAGCGAATAGATGTCGCTGTCCGACCGCACGCCGGGATACCGGAAGAGGTCCCAGGTGCCGCCCATGCGTTCGCGGCGTTCCAGGATCAGATAGTCGGCGCCGGGATTCTGCTCTGTGAACCGGTAAGCGCAGTCGATGCCGGACAGGCCGGCGCCGATGATGATCATGTCGCGCACGGATGGCTGTGTGGTGTCGGTGTCGCTGTCGGTCACGGGGACCTCCTCGGTGGGGCTGCCTGGCGTGCTGTCATCATGCAACACTTGTCGTCAGATGTGAACGGAATCACACCGAACCGCAGGCCAGCCCGTCTGCGGTCGTCATCGAGCGAGGTCGAGGGGACGCACAGATGCCGATGGAGAAGCACACCTATTGCCGGATCTGCGAGCCGCTGTGCGGCATGATCGCCACCGTCGAGGACGACCGGCTGATCTCGCTGCGGCCCGACAAGGAGCATCCGCTGTCGAGGGGTTTCGCATGCCCGAAGGGGATCGCGTTCACCGAGATCGTCAACGACCCGGACCGTCTCCGGCACCCGCTCCGGCGACGCCCGGACGGCGAGTTCGAACAGGTCTCATGGGAGACCGCGCTCGATGAGATCGGCCGCAGGCTCGTCGAGGTCCACCAGACCTCCGGCAGCGACTCGATCGGTTGGTACTTCGGCAACCCCGCGACGTTCTCCACCGGGCACGTGCTGTGGACCGCGATCTTCATGAACCTGCTCGGCACACCGCACGTGTATTCGGCCGGATCGCAGGACGTGAACAACCGGTTCGTCGCCAGTCACTTCCTGTACGGGAACCCGCTGACCGCACCGATCCCCGACATCAATCGCGTCGACTACCTGGTGATCATCGGTGCGAACCCGGTCGTGTCGCACGGCAGTGTGATGAGCTCCCCGCGGATCCGCGAGGGTTTGAACGCCATCACCGCACGCGGCGGGTCCGTCGTCGTCGTCGATCCCCGCCACACCGAGACCGCCCGCGAGTTCGACTGGCTGCCGATCACACCCGACACCGACGCACTGTTCCTGCTGTCCGTGCTGCATGTGCTGTTCGACGAGGACCTCGCCGACCGCGACCGGCTTCGACGGCAGGCGCGGGGAGTGGGGGAGCTCGAGACGCTCGTCGCGGCCTATGCACCGGAGACGACCGCGGATCGCACCGACATCGACCCGGAGCGCGTCCGTGAGGTCGCCCGCTCGCTCGCCCGGACGGAGCGGGCGGCCGTGTACGGCCGGGTCGGGACGTCGTTGGGGCGCACCGGGACACTGACGACCGCGCTCCTGGACATGGTCAACCTCGTCGCCGGGAACCTGGACGTGCCGGGCGGGTCCATGTTCGGCGATCTGGGAATCCCCGGGCAGCGGCTGGGAGTGAGCGCACTGCAACGGGTGTCGAGCTTCCGGTGGGCCGGACGTCGGAGTCGGGTCGGCGATCTGCCACAGGTCCTCGGGACGGCGCCGGCGTCGCTGATGGCCAAGGAGATCACCACGCCCGGTCGCGGACAGCTGCGAGCCCTGTTCGTCAGCGCGGGCAATCCGGTGCTGTCGGTACCCAACGGCGACGAATTACGTTCGGCGCTGGACGAACTCGATCTCATGGTGTCGCTGGACATCTACCGCAACGAGACGAACGCGCGGGCCGACTACATCTTGCCGGCGACCACGATGTACGAGCGCGAGGATTTCCTGCTCCCGTTCCAGGCGCTGTTCACCACCCCGTTCAAGCAGGCGACCGAGGCGGTGATCCCCCCGCAGGGTGAAGCGCGGGAGGAGTGGACGGTGATCAACGAGCTCATCGGTTTCCTCGCTCGGGAGAATGTGCTGATCCGTTCGCTACATGCCGGCAATCGGTTGGCGCGACGCATTGGGCGTCCGGTCACCCCGCGCGGGATCTCCGACCTGGTGATCCGAATGGGGTTGGGCGGGGACCGATTCGGTCTGCGTCGAGGCGGCTTGACCTACCGCCGCCTGGTCGAGGACCACCCGCATGGGGTCGTGGTCGCCGACCACCTCGCACCTGGGCAGCTGAGCAAGAATGTCACATACCTCGACGGTCGAATCCGGTTGGCTGCGCCGGAACTGATGTCCGAGATCGGGCAACTGGGCGTGGACGCAGACACGGGTTATCCGTTGCGGCTCATCGGAATGCGGGAGATACGTTCGGAGAACAGCTGGCAGCACAACGCGCCGATGCTGCTGCGCGGCGGACGGTCTCACGCGGCCCGGATACATCCAGACGATGCCACGGCACGCGGCCTGGCCGAGGGCGACCTGGCGACGGTGGCGTCCCGACACGGACGGATCTCGTTGCCGGTCACCATCACCGAGGACATCAAGCCCGGTGTCGTCGCGATTCCGCATGGCTGGGGCCACAACGGCTCCGGCGGATGGACGCAGGCGAATGCAGCGGCGGAGAATGATCTGGGTGCCGGCGGAGTGAACGTCAACGCGCTCATCTCCTCCGATCCGGCCGATCTCGAGCGACTCGCGGGGATGGCCAACATGACCGGGGTGCCGATCCAGGTGTCGGCGATGTCCGAGAGTCGCCTTCAGTCGGCCGACACGGTGGAGCCGGCTCGGCACTGACCGCGCACAGCACGATTCTCACCGACGGGTCTCGTCGGTGAGAATCGTGGAAAGTGCTGTCACACAGCGGCTACGGTGAGATCACTCGCCGGCCGGGGGCATCAGCACCGTGTCGATCAGGTAGACCTGAGCGTTCGACGTGGTGACGCCGCCGCAGACGACGCCCGACTCGTTGACCTTCAGGTTGTCGCCCGAACCGGTCACGGTCACCTGCTGACCTTCGAGAGTGGTGTGCTCACCGACGATCTTGTCCGGAGCCGCCTGGCCCTCGACCACGTGGTAGGTCAGGATCTTGTTCAGCAGGGGGGCATCGGTCTTGAGCTGCTCGACGGTCTCCGGGGGCAGCTTCGCGAACGCGTCATCGGTCGGCGCGAACACGGTGAACTCACCCTCGTTCAGCGTCTTCACGAGGTTCACCTCGGGATTCAACTGGCCCGAAAGCGCTTGTGTCAGCGTGGTGAGTTCGGGGTTGGTGGCAGCCGCGGTGGCGACCGGCACGCTGGACATGCCGTTGACCGATGCCGGGCCCGAGGGGTTGGCCTCGGCGTATGCGGCGCAACCGGGTCCGACGAGATTGGCGGCGGGATCGGCCATCGCGCTCTCGCTCATCATGGCGCTGGATTCGGTTGCCGCGCCGGTGGTCTCGCTCGAGGTGTCAGAGTCGTCGCTGGAACAGCCGGCCATCACGCCGACGGCGAGGACCAGTCCGGTCAACGCTCCTGCTACGCGGGGAACTCGCTTGATCATCGTTGATCCAATCTGTGATGCGGTGTCGACTGCGCCTGACCGGCAGCCTCATAACGTCTTCGGTGCCGGGCGATCCGCGGATTGGTCAACGACGAGACTGATCGTGAAGGGCGCCTTGTCGGTCAGGCCGTCGAGGGCGTCACTGGGCCCAATCCTGGTCGGCCCAGCCCTCGGCCCAGTCCTGGCCTTCGGAGACCGCGCCCATGGTGGTCTGGCCGTCCAGCGCCTCACGGATGATGTCCGCGTGGCCGCAGTGGTGCGCGGTTTCCCGGATGAGATGGATGATCATCATCCGGATCGACGACCACTCGCGCTCGGGCGCCCACGGCGCGGTGGGCTGGGGAATCAGCTCGTCGAGGTTCTCGGCGTCGGCGATCACGCGATCGAGCTCGAGCGCGGCACGGTCGTACTCGGCCAGCCACCCGGCGATGGTCTCGTCGTCGCTCATCACGTACTCGGTCATGGCCTGACTCATGTCGAACTCCGCGTTCTCGTCCCGCTCGGTGATGACCTTCGCGGCTCCCTCCTCGCCATGGGCGAGGTGCTTGATCAAAGCGCCGATCGTGAGGGTGCTGACCGTCGTCTGCTTCCGGGCATCGGCGTCGGAGAGGTTGCGTGCCGTGATCTTGAGCATGTTGCGCTGGTCCTGGAGCAGGGTCAGCAGGTCGAGCTTCTCGCCGGTGACCTCGACGCTGACTTCCGCGGGGGTGTAGGTGCCCATGATGTGTCCTCTCGGTTGGTGTGAGGACCACGTTATGAGCGATAGAGGACAGGTTCGGTCCTCGTTTAGCCGAGTTCTTCCATCAATCGGGGGAACCGTCTGGAATTCGCCCAGCAGCGCGACGCCGGCGACGAAATGTCGCCCGACCCGGTCTGCTGGGTGGTTTTCAGCCGGGGTGGGAGAGTCCTGGTCTGAGGCAGCAAATCTGTTGAACCGGGGGCCGACGCGGGCGACCATGTCCGCATGACCTCGAACGGCGTCACCCCGACCGACGCGACTTCGCCGCTCGCGTCGCTGACGCGCAAACCCGAACGGGCCGCCGACCGTGCGTTGCTCGACGCGCTGCTCGACGAGGCGAAGGTCGGGACCCTCGGTACCGTCGTCGACGGACTGCCGTGGTCGGTGCCGATGCTCTTCGCCCGGGACGGCGACTCGATCCTGCTCCACGGTTCCACCGGGGCGGGCGCACTGCGGCACGTGGCCGCCGGTGCGCCGGTGACCTTCACGGTCTTCGTCCTGGACGGTCTCGTCGTCGCCGACACTCTCTTCGACCACTCGGCGAATTACCGTTCGGCGGTGATCCGGGGCGTACTCGAAGTGTCCGGCGATGCCCAGACGGACCTCGAAGTGCTGTCGGACAAGCTGATTCCCGGACGTGTGGCCGAGGTTCGGCCGACGACCCGCAAGGAGCTGGCGGCGACCGTCGCCCTCCGGTTGCCGATCGCCGACGGTCAGTGGATCGCCAAGGCACGGACCGGTGGGCCGGGCGGGGGGTCGACGGACTGGACCGGGGTGGTCCCGGTACGAACGGTGTACGACGCCCCGCTCACCCACAGCGGAGGGACGCCGCCCGAATCGGTACGGGCGCTGGTGGGCCCGTCGCCGTCGACCGAGGCGCGCGAGTGACGGAGAAGCGCAACCAGCGGATAGGGGTGTGATCCGCTGGTTGCGCGTCCGGTGACCGCGTCGGGTCGGGCGAGGTCGTCGAAGCCCGGCCGACGGGGTCGGTCTGGGCGCGGCCGGGCTCGGTGGGCCGCGCAACCGGTTCATCGCTCCCGCGCGGTGGCGCCGTTACGCGCCCGAGCGACTCATCTCTGGCGGAGCAGGAACCGCTGGATCTTGCCGCTGGGTGTCTTGGGCAGGGCGTCGACGAAGTGCACGGTGCGCGGGTAGGCGTGCGCCGCGAACTGCGTCTTGACCAACTGCTGGAGCTCGGCCTCGAGAGCGTCGGAACCCTCGACCCCGTCGGCGGTGACGACGAAGGCCTCGAGGACCTCACCGCGGAGTTCGTCCGGGCGACCCACGACGGCGACGTCGACGACCGACGGGTGGGTGATCAGGACGCTCTCGACGTCGAACGGGCCGATCCGATATCCGGCCATGATGATCACGTCGTCGTCGCGTGCCGTGAAGAAGTAGCGACCCTCGTCGTCGACCCGGCCGGTGTCGCCGGTCAGGTACCACCGCCCGTCCGGCGAGAACCGCTGCTTGGTCTTCTCCGGTGCGTCCAAATAGCCCTCGAACCACATCAGCGGGCTGGCCGGGACATCGATGGCGATCTGGCCGTCGACGATGCCCGCGGCGAAGCCGGGCATCGGCTGACCCATCGAACCGGGCACGAGGGTCTCGTGCACCGACTCGTGCCAGTGGTTGTTGATGAACATGCCGTGTTCGGTCTGGCCGTAGTGGTCGCGGACCTCGGTGCCGATGGCGCGGAGCGCCCAGTCGATGACGTCGGGGGTCAGCGGTTCGCCGGCCGAGGACGCCCGGCGCAGCGAGAACCCGGAGATGCGTGAGTCCTTGCTGAGCGCGCGGTACACGGTCGGCGCGGCCGCGAAATTGGTGACACCGAGCTCGCCGAGGATCTTCGCGGTCAGCTCGGGGGTGAAGCCGGCGTGCAACAGGAGGTTGCGCCTGCCGGCGGCCAGCGGACCGAGCACGCCGTAGTAGAGGCCATAGGCCCAGCCGGGGTCGGCGGCGTTCCAGAACACGTCGTCGGCGCGGACATCGAGGCCGAAGTGCATGTAGGCGACGAACGAGGCGAGCGCCTTGACCGGGACCGGAACACCCTTCGGTGCCCCGGTGGTGCCGCTGGTGAAGAGCAGGATCAGGGTGCCGTCGCCCCCGACCGCCACCGACTCGGTGACCGGTTCATGCGAGGAGATGAGTTCCTCGAACTGCTCGCCGGCGATCACCGTGGTGATCCCGTCGATGCCGGCGAGTTTGTCCGCCTGACTCGGCTCGGTGATGACGACCTTCGCGTCGCCGGCCGCCAGGCGCATCTCGATCGCGGGTGTGGCGAACGCGGTGAACAGCGGGATGTAGATCGCGCCGAGTCGGGCGATCGCGAGGAGCGACACGACGAGTTCCTCGCGTTTGCCCATGAGGACGCCCACCGTGTCGCCGCGACCGACGCCCATCTCCGCGAGAGCCGCGGCGAGTCGCTTGGACCGCTCGGCGAGCTCGCCATATGTGATGTCGGTGGTGACCGGGCGAACACCGCCGGACTGCTGATCGCCGGTCTGCTCGACCTCGATCACGGTGAAGGCGATCGCGTCGGGATCGTGACCGTCGACGAGCAGCGACGCGGCGTCGGCGTCGGGCGCCCCGTAGATTCCCAACCAGCGATCGACCATGTCGACGGGCTTCGTGGTGGCCTGTGTCATCGTGAACCTCGCTCCGTACTGAGTAAGCTGAGTCACAGTGTCCTCCGCGACATGCCCCCGGAACACCCCCTGAAGAGGGGGAGAAGTGAGGTGAGATGCCCGAGCCGCTGAGCGGGATCGTCACCGAGGCGTTGCGTCGAGTGCGCAGGTCCAGCGGGGTGCCGCTGGCCTTCGCGGGCGTCCTCAGCGGTCCGTCGAACCTGCGCCTGCAGCACTTCGCCGGATCGACGGTGGGAGCGTTGAACGGCGTGTCGGTCGACGTCGGCCACGGTCTGGGCGGCAAGGTCGTCTCGCTGAACCGCCCGATGGTCGTCGACGACTACCTCCGCACCCCACGCATCACCCATCGCTACAACACGATCATCGAGCGGGAGGGACTGCGCGCCATGATGGCCGCGCCGGTGATCGTCGACCGCTCGCCCGTCGCGGTGCTCTACGGTGCGTTGCACACGCCGGACCCGATCGGTGGGCGGATGCTCGACGTCCTCGCCATGGAGGCGCGCACCGTCGAACACGAGATCGTCGCATCCCGCGCACGTCTGGAGCACGCCGCTCAGGACGAGGCCGAGATGCGCGACCGGATGACCGCGGCCTACGCCCGACTCCGATCGCTGGCCGACACCGTCGACGACGCCCGGCTCGCCGATGAACTCGCCGCGATCACCGAGGTCCTGGTTGCCGCGAACCCGGTGGCGCAGACACAGGTGGACCTGACCGGCCGGGAGCAGGACGTGATCTCCCTTGCCGCACTGGGTTACTCGAACGCCCGGATCGCCGAGACCCTCGGCGTCACCGTGTACACGGTGAAGGGCTACATGAAGGATGCGATGCGCAAGCTCGGGGCGTCGTCGCGACTGGAGGCCGTGGTGACCGCCCGCAGCGCCGGCCTCCTGCCCTGACGGACTCCACTCAGTGAGGAGCGCCCGGAGCTTGCGGAGGGCGGCGGCGCGTCACCCTGCTCCCTGATTCAAAAGAATCCGCCCAATGGTCCCTGAGGTGCGAGGAGCGCAAGCGACGAGCCACGAAGACATCCCAGGGGTCCAAGGTGTCAAGCGGCGAGGTGTGTGCGGTGGTTCCATGCGGTGTGTTCGTTGTAGTGGGTGCGGTGGGTGAGGCAGCCGTGGAGGATGCCGATGAGCCGGTTGGCGACCGCGCGTAGTGCTTGGGTGTGGGACTTCTTCTGATCGCGGAGGCTGTCGTAGTAGACGCGGGCGCCGGGGCTACCGGTCAGAGCGCTTTGCGCCATGCACAGTGCGGCGGCGTTGAGTCGGGTGTTGCGGATGTGGCGGGCCAACACGACGTGCCCTTTGCCTGAGGCGATGGTGCGTGGTGAGGTGCCGGCATAGTTTCTGCGAGACTTGGCGGTGGCATAGCGTTCGGGGTCATCCCCGAACTCGCCGAGCATCCGGGCGCCGGTGATGTCACCGACTCCGGGCATGGACAGGTAGATCTCGGCGTCCGGATGCGCTCTAAAAGACTGGGCCATAGTGGTTTCCAGTTGGATGATCTGGGTGTTGAGAGCGGCCAGCATTTCCACGGTCGCTGTCACGGTCGCCGCGTAGGCGGCGGTGAGTGCCTCGGGTGCGCCCAGATGGCCGCCACCGCGTAGGGCGTGCTGGATGTCGCGGGCACGGGTATCGGTATTGCGTTGTCGGCCACCCTTTTTCAGGGCCGAGCGGATCGCCGCGACCGATAGTGCCGCACCCTGTCGTGGGGTGGGAGCGCGACGCAACACCGCCAGACAGTCTTTGTGGGCGAGGTCGCCGCCGAAGGCATCGACCGCGGCCGGGTAGTAGGCGCCCAGTTGGGAGCGCAACACATTCTGTTGCGCTGAACGCGCCCACACCAGGTTCTGGTGCGTGCGGGCCATCACCGTGATCGCGTCCGCGGCGACGGTATCGGCGGCGACGAGCCGATGGTTGTGCCGGTCGGTACGCACCAGGTCAGCCAGCGTTTTCGCGTCAGCCTTATCGGATTTGGTGCCCCCGACATGGTGGCGGTCGCGGTACCGCGATACCGACAACGGGTTGATCGCGTACACCTGATAGCCCGCGGCGACCAGGGCGGTGACCCACATGCCGTGATCGGTTTCGATCCCGATCACTACCTCGCCAGGCTCTTGGGCATACCGGGCGATCAGTTCATGCATGGTGGTGGCGCCGGCAGCGTTCTCGGGTATTCGGCGGGTGGCCAGGGTGGTGCCGTGTTCATCCATCACGCACACATCGTGATGATCTGATGCCCAGTCGTTGCCCACAAAGATCATGACACTCGTTCACCTCGTCTTCGGTCGTCTCGACGATCTGGTGTGAACCTTTGGGTGATCACCCTGACGCGGCCTAATGGATCAGTGCTCACCCACACGTTCAAGGGGGCACGACATCCCAGAAGCGTTCTAGCGGGTGATCCTCGCCCGGCCGGGCCACGGTCTTCGTGTAGAAATCCGACACCGTTTCAGGGCCTGGCAGTGGTCACCGACCGGGAAGGCTCACACGACCAGCATCCCCCAAAAGGAAGCCGATCCACCCCCATTAGGGCCTGGTGAGACGTCTTGCGAAACCCTTCGTGGCTCGCTTCGCTCGCACCTCAGGGAGCAAGGAATTCGGACGCGTCACCCTGCTCCCTGAGGAGCGCCCGGAGCTTGCGGAGGGCGCGTCACGAAGGGTCTCGCGACCCCGGTCGGAGGGTTGATCCGCGCGCGGAGGGGTAACACCGGGTTCCATGCGAACACTCTCGGCGACACTGCTGACCGCAGCTCTGCTCGGAACACTTCTCGTCGCCGCGCCGGCAACGTCGACGGCGGTACCGGCCGAGACGTGTGGCACCGAGCTCCGCCCGGCCGACCGCGAGCGGATCGTCGAACTCGGTACCTACGATCAGGATTCGCGGGACCTCCCGCTCGTGCAGCTACGACGCAACGTCGCGAAGCTGTACGGGATCGTCGACATCCTCACCGACCGCCGCGACCGTCGCGGATTGTTCGCCCTCGGACTGGCCGCAGTGGAACGCGACGCGGTGATGCCGCTGCAGAACAATCCGCGCGTGTTCCAGACGCCGCGGTGGGCCCCGGTGATCAGTCTCGAACTCCTCAACCGGTTCCTCGACGCCGTCCGAGGCGAGTTCGGCGGCGGACCCGTGGCGCCTCAGTGGCGGCACTACTTCGACATGGCCGACGATTGCGCGGTCCCCGGCCAGCGGGTGGCCATGGCCGGCTACAACTCGCACATCACCGTCGACCTGGCGTATGCGACCGCCGACGCCCGGGCGACACCATCGAACGCTCGGGACTTCTTCTTCATCGTCGACGCCATTGCTGCGCATGGGAACTCGATCGTCACGGAAACACTGCGGGAGTACGGCGTCGACCTGGGTCCGATCTTCCGCTTCTACATCGTCGGTGAGGGACTCGACCGGGTGGTCGGTGCCGGGCGCGCGACCGGGCCGATGCTGCGCGCCGCCGATGTGGGCTACAACGTACTGACGTTCCGCAACGGCCTCGCGCTCCAAGACGTCCGTGCGGCGCCCGGCGCGCGCGGCGACGTCAACGCGCTCTGGAACACCGGGGAGACCGCGCTCACGGCATTCCAGCGTGTCGGTCTGGTTCGCTGACCACTGCCCGAAACGTGTGGGTCGCGTGCGGACGAACCATGTGGAATAACTCGCCGAGGGACGCGGTTGTAGCCCTCGACGGTGACGGATCCATTGCCCCGGGTCCCACCCTTATGCCGCTTCGAGCGGCCTGTTTGCCGAGAGGCGCACTGGCCGGCACCGTCCCTTTTCACACCGAAGCCGCCGAACCCTCAGGGGTCGGCGGCTTCGGTGGTGTCGGGCCCGGCGGATCGGGTTTCAGTGATCGCGGAGCTTCTCGATCAGCTCGTCCTTCTTCAGGTCCGAATAACCGGAGAGGTCCAGTTCCTTCGCGCGCTTCTTGAGTTCGTCGACCGTCCAGTCCTCGTAGGAACCGGACCTGCCGCCGCTCTTGCCGACGTCCGACCGCGAGCTGTTGGCCGCGGCGTTGGCGATCCGAGCGGATTTTTCCTTCGAGTTGCCCTCGTCGCGCAGCTTCTCGTAGAGCTCGTCGTCCTTGACCGAGGGTCCAGGGTCCTTCTTGTTCTCTGCCATGGTGTACCTCCTCGTGGTCGAGATGCTGAGTACGTCGCAGGGTTGCCCCGACGTGGCCGTCGTGAAACAACCTGCGTCGGCATGGACGCCGCGGGCTCGGTGTTCGCAATGGCCGAAACGGAGTCGAATCGGCCGATCGCGAGCCTAGGGTGAGGTCCGAGCGGGCCCCGGCGCCGGACCACCACTGGGTGTGGCTACCAGCAGTGGACGACGGCTACTCACAATAGATCGGTGTCCGCCCTACCGATAAGGTTGTGGCGATGTGTTCCGGCGATGCCACGACGCGTCGCCGTCCTTGCGAACACACGTTGCACACGTACCCCGAACAACGCAGTTGCGGAAGGAAGAACGCATGTCGCAGACAGTCAAGGGAGTCATCTCGCGCAGCAAGAAGGCGCCGACGGAGGTCGTGGACGTGGTGATCCCGGATCCGGGTGCGCGTGATGTGGTGGTGGCGATCAAGGCGTGCGGTGTCTGCCACACCGACCTGGCCTACCGCGAGGGTGGGATCAACGACGAGTACCCGTTCCTGCTCGGGCACGAGGCCGCGGGTGTGGTCGAGTCGGTCGGTTCCGATGTCACCCATGTCGAGGTCGGCGACTTCGTCGTCCTGAACTGGCGGGCGGTGTGTGGTCAGTGTCGGGCGTGTAAGCGGGGTCGTCCGTGGTATTGCTTCGACACCTTCAACGCCAGTGTCCCGATGACATTGACCGATGGCACCGAGCTGACCCCGGCGCTGGGTATCGGCGCGTTCGCGGAGAAGACGTTGATCCACGAATTGCAGTGCACCAAGGTCAATCCCGACACCGACCCGGCGGTGGCGGGTCTGCTCGGTTGCGGTGTGATGGCCGGGATCGGTGCGGCGATGAACACCGGCAACGTGGGTCGTGGCGACTCGGTTGCGGTGATCGGCTGCGGTGGTGTGGGTGATGCCGCGATCGCCGGGGCTCGGTTGGCCGGTGCGACGACGATCATCGCGATCGACCGCGATGCGTCGAAGCTGGAATGGGCCACCGACCTCGGCGCCACGCACACGATCGACGGGTCGAAGGTCGACGATGTGATCGCCGCGGTGCAGGAACTGACCGACGGCAACGGCGCCGATGTCGTGATCGACGCGGTCGGCCGTCCGGAAACCTACAAGCAGGCGTTCTACGCCCGCGACCTGGCCGGGGTCGTGGTGCTGGTCGGTGTGCCGACCCCGGAGATGACCCTGGAGATGCCGCTGGTCGATTTCTTCTCCCGCGGTGGCGCACTCAAGTCGTCCTGGTATGGCGACTGCCTGCCCGAGCGTGATTTCCCGATGCTGATCGACCTGTACGAGCAGGGGCGTCTGCCGTTGGACAAGTTCGTCACCGAACGCATCGGTATCAACGATGTCCAGGCCGCGTTCTCGGCGATGGAGGCCGGCAAGGTGCTGCGATCGGTGGTGGAGTTGTGAGCGGCGAGTTGCGGATCGACAACGTCGTCACCTCGGGCACGTTCAGTCTCGACGGCGGCACCTGGGACGTCGACAACAACGTGTGGCTCGTCGGTGATGACGACGAGGTGATCATCATCGACGCCGCGCACTCGGCGAAGCCGATCCTCGACGGCGTCGGCAACCGGACGGTGACCGCGATCGTGCTGACCCACGGGCACAACGATCACGTCACCGTGGCCCCGGAGCTGTCGGAGGCGACCGGCGCGCCTATCCTGCTGCACCCCGGCGATGACATGTTGTGGAACGACACCCATCCCGACGTCGCCCATCAGGATCTGGAGGACGGCCAGCGGATCAGCGTCGGTGGGACCGAGTTGACCGTCATCAACACCCCCGGCCACTCGCCGGGGTCGTCGGTGATCCATCTGCCCGAGGCGAAGGTCCTGTTCTCCGGCGACACCCTGTTCCAGGGCGGTCCGGGCGCGACGGGGCGTTCGTACTCGAGTTTCCCCACGATCATCGCCTCGATCACCGAGAAGATCTTCACCCTCGACCCCGAGACGAAGGTCTACACCGGCCACGGCGACGGCACCACCGTCGGCGACGAAGCACCCCACCTCGAAGAATGGATCAAACGCGGTAGCTGACAGGCCGAATGCGGCATCCGCTCGGCCGACTACCGCCCGTTCTCGGTAGCGGCGCGGGCGGGTGGCGGCCGCGGAGGATGCGTCAGGAGACGGACGCGACAAGGACTCGCAGCAGTCGTCGAAAGGTCGTTGCCTGACTGTCGGACATGGCACCGTGGAGTAGCTCGTCCTCCACGGCACGTATCTCGGCCTGGACGCGCTCGTGCAGTGCATGCCCCTCCGAGGTGATCGAGACGGTCCACTGGCGATGACTGCCCGACCTCTCCCTGGACACGATGCCCCGCCGCTGGAGTTCGTCCAGATGTTTGCCGAGTCGCGTCGGATCTCGCCCGGTGCGTTCGGACAACGCACGCTGCGACACAGCCGGCGTCGCGGCGATCTCGCCCACGATGGCGTACTCCCACATCGACAGGCCGGCGGCCCGGAGGATCGGCTCCTCGAGGCTGATCAGGTGCGGGATCAGTCGCCCGAGAAGTGCGCCGAGATCGGGCTCCGCACTCGAAACCCGGTCGTCGTCCGCCATCGACATCCCCTCTCAGATCGTCTACCGTGGTAGACGATCGTTGCGGCCGGTCACTCCCGCTCGATGCGGAAGCGTCCTCTCATCATCGCGGGCCGACGGGACGGATCGACAGTTCGGATGGGCACTGTCTTCGAGAAGGGGCGTCGGATGGACACAGCGGCACTTCGGGCGACGACCGACGATGTCGGCGCACATCTCTCCGAGATGACCGTCGGCGACATGAGCATTCCGGCCGCCGCCACGAACGGTGACCTCGGCGATCTGTTCGTGGCGGCCGTCGATCGAAACGCGCGTCTCACCGCGCTCCTCGCCGGCGATGAGCTGATTTCTCAGCGAGCTGCACCGATCGACAGGGCATCGTTCCCGTTGGTGGCGGACCAGTACGGAGGCGGTTTCGATCACCGGTACCGTCGAAGTGCCGGCCTGATGGTCGCCGCCTTCGCCGGAGTCCTCGACACGCACCGGGTCGTCGACCTCGACGGCACCCACACAACCGCGGGAGCGCTCTACGAGCACGCGGTCCGCGATGCCTTCTTGCTCACGTGGAACATCGCCACCGCAATCGACATCCGGTATCAGCCGCGACCCGACATCGTTCGAGGGGTCATCCAGACGATGCTCTCGCACATCGAGGATGCCGATCTGGCAACGGCAGTCGACGTCCTCGTCCAACTGTCGGGTCCACACCGGGACAAGTGAGGAGTCGCGGTGGGACTGCGATGGAGCCGCGCCCGTCGGGTGTCGCCGTCCGCTCAGCTTTTTCTCAGGGGTCGGAATCGGCGGCTCGAGCCGCAGGCGTAACGTCGCGCGGATGAGCGATTCCGCGGTCCGCAACATCGACCATCCCGACCAGGCGCCGGTACCCCGTAGCCGCATCGTGATCGCGTCGATGATCGGGACGAGCATCGAGTTCTTCGACTTCTACATCTATGCGACGGCCGCGGTCCTCGTGTTCCCGGTCCTGTTCTTCCCCAAGGGGGACGACACCGCGGCGCTGCTGTCGTCGTTCGCGACCTTCGGTCTCGCCTTCGTGGCGCGACCCATCGGCTCGATCCTGTTCGGCCACTTCGGGGATCGCGTCGGCCGGAAGGCGACACTGGTGGGGTCGCTCCTCACCATGGGTATCGCCACCTTCGTGATCGGTCTGCTGCCCACGTACGACTCCGTCGGCTACCTCGCACCGGCGCTGCTCGCGCTCATGCGCTTCTGCCAGGGCCTCGGACTGGGCGGAGAGTGGTCGGGCGCAGCGCTTCTCGCGACCGAGACGGCCGAGAAGGGCAAGCGCGCGTGGGCGGCGATGTGGCCGCAACTCGGCGCACCGATCGGCTTCTTCTTCGCCAACGGTACCTTCCTGCTGCTGATGCTCGCCCTCGACTTCGACGCCGCGTCCGCCGACCCGGACCATGCCTTCATGACCTGGGGCTGGCGAATCCCGTTCCTGGCCAGCGCCATCATGGTGGCCGTGGGGCTGTATGTCCGGCTGAAGCTCACCGAGACACCGGTGTTCGCGAAGGCCGTCGCCGACGGCAAGAAGGTCAAGGCGCCGCTCGCCGAGGTCGTCAAGACCAGCTGGCGTCCGCTCATCGCGGGCACGTTCATCATGGTCGCGACGTACACGCTGTTCTACATCGTGACCACCTGGGTGATCTCGTACGGCACCGGCAAGGTGACCGACGAATCGGGTGTCAAGCTCTCCATCAGCTACGTCGACTTCCTGCAGCTGCAGCTTGTCGCGGTCCTCTTCTTCGCCGCGTGCGTGCCGATCTCGGGACGCCTGGCCGATCGGTACGGGCGACGTGCGTTCCTCATCATCATCACCGCCGCGATCATCGTGTTCGGCCTGTGCTTCCAGTGGCTGCTCGATCCGTCATCGATGACCGACGGAATGATGCTGTTCTTCCTGATCCTCGGGATGACGTTGATGGGGCTCACCTTCGGGCCGATGAGCGCGATCCTGCCGGAGCTGTTCCCGACCAACGTGCGGTACACGGGTTCGGGGATCGCCTACAACGTGGCGTCGATCCTCGGCGCCGCCGTGGCCCCGTTCATCGCGACGTGGATCGTCGCGGACTACGGCGTCGGCTGGGTGGGCGTGTACCTCGCGGTCGCCGCCTGCGCCACCATGATCGCCCTGCTCAGCGTCAAGGAGACCAAGACCGTCGACCTCACCGAGGTCTGAGTCACGGGCGCGCTGCCGACCGGGATTGTCGGCGGCGCGGCGTACCGTCGAACGGGTGAATGCCCGTCCGGTTGCAGGTGAGGCGACATGAAGCTGACCGACGTCGTCCAGACCTCCGCGGATGTCGCGCGCGACCGGTCGCGAACCCGTAAGACAGCGGTGCTCGCGGAGGCGCTCTCGGCGACGTCGGACGCGGAACTGCCGATCGTCGTCGCATGGCTTTCCGGCGAGATCCCCCAAGGGCGTCTCGGCGTCGGATGGCGGTCGTTGTCGAAACTGATTGCGGCACCCGCGGAGTCGCCGACTCTGGAGGTCGCGGCTGTCGATGCCGCCCTTGGTGAGCTCGCGTCGGCGTCGGGCCCCGGGTCGACGAAGCGCCGCGGCGAGATCATCGCGTCCCTGTTCGCGGCGTCGACCGAAGCCGAGCAGAAGTTCCTCGTGGCACTGCTCACCGGCGAACTGCGGCAGGGAGCACTCGCCGGCGTCATGACCGACGCCATCGCCAAGGTCACCGGCCAGGATCTGGTGCTGGTGCGTCGGGCGAACATGCTGACCGGTTCGCTGCCGGAGACCGCGGCGCTGGCCCGGTTCGGGGCCGAAGCGTTGGCCGCGGTGGGCCTCGAGGTCGGTCGTGCCGTCGAACCCATGCTCGCGACCCCCGCCGACGATCTCGATTCCGCTCTCGCGCTCCTCGGGCCCGACCTCATCGTCGACTACAAACTCGACGGAGCGCGGATCCAGGTTCACCGCAAGGGGACCGAGGTCTCGGTGTTCACACGCACATTGCGGAACGTGACGGCCAACGTGCCCGACCTCGTCTCGGTGATCGCCGCGCTACCGTGCGACTCGGTCATCCTCGACGGGGAGACGCTGATGCTCTCCGACGACGGCCGACCGCGGTCGTTCCAGGACACCATGAGCCGCTTTGGTTCCGGGCCCACGGCGGCGGGTGAACCCGAACGCCTGCTCAAGCCGTTCTTCTTCGACTGCCTGCATCTCGACGGCACCGACCTGATCGACCGCCCGCTGTCCGAGCGGCTCGCCGCCATCGACTCGATCGCCCCGCAGCTGCGTATCCCGGCCGTGACGCGGCCGAGTGTCGAGGAGGCGCGCAACCACTTCGACGCCGCGATGGCCGACGGTCACGAGGGTGTGATGGTCAAATCGCTCGACGGCCTGTACGTGGCCGGCCGTCGTGGAAAGGCATGGCAGAAGGTCAAACCGACGCACACCTTCGACCTCGTCGTGCTGGGTGCCGAGTGGGGGTCGGGGCGTCGCTCGGGCTGGCTGTCGAACCTGCATCTCGGCGCCCGCGATCCGGAGACGGGGGAACTCGTGATGGTCGGCAAGACGTTCAAGGGCCTGACCGACGAGCTGCTGCGCTGGCAAACCGAGGAGTTCCCGAAACACGAGACGCACCGGGACTCGTACACGATCCACCTGCGCCCCGAGATCGTCGTCGAAATCGAACTCGATGGTGCGCAACGGAGTTCGCGCTACCCGGGTGGTGTCGCGCTGCGCTTCGCGCGCGTGGTCCGATATCGGCCGGACAAGACCGCGGCCCAAGCCGACAGCATCGAGGCGATCCGCGCGTTGTTGAAGTAACTCTGGAAGCCACCCGTGGAAACCGGACAGCCGCCGATATGTCGCCGGCCCGGCTCCACGGGGTGGTTTCCAGGAAACGGCCCGGTCAGGTCAGCGACAACTGCGCCACCGGGGTGGTGGTGGGCCGGTCCGAACCGCCGGGTGGTTCGACGGTGAACGCCAGCGTCGAGGCGGAGTTGATCCCGGACAAGACGGCGGTGGTGACCGGTTCGACGTCCTTGTCCGTCATCGTGCCGGCCGAGCGGGCGCCGTCCGGCCCGATGAGCCACATCTGATACACCGTCCCCGGTTGAGGCGGCGGGACCGAATCCATGACCAGTACGCCGGTGTCCGCAGACTTCGCGAGGTAGACGGTGACGTTCCCGGTCGCGACCGGACCGCCGGTCGATCGCAGGTCCTCCGCGGAGAAGACCTGCTCGGCCGGTGAAGCGAGCGGGCGCACCTCCGGTTCCGGGGAACTCGACTGTCCGATGACCCACCCGGCGGCGCCGATGGCGACGGCGAGGACCGCCGCGGCGGCGAGATATGTCCAACGGCGAGACCTGCGTCGGTCATCGGCCCCGGTCGCCGGGGAGCCGGCGGCGGATTCCGGTTGCCCGACGTCGGTGCCGGCCGATGCGGGGTCCTGCTGGGGCATCGGATGATCCGACGCGCCGGACACGACCGGTCCGGACGCGGACGCGCCGGCCGGTTCGGCGAGGTCCGGCGCGTCGAGACCCGCGTCGGCACGCGCGGCGGACAGGATGCGGTCGCGGAGCGTCGGCGGAGGTGGCGTGGCGGTGGTCTTGCTCATCGCGGCCAGCGCCTCGCGGGTCGCGCGGACCTGCTTGTCGAACAGTGCGCGGACATCGTGCGGCGCCCCTGCGACGCGCTCCTGGACGTCGCGTAGTTCGTCATCGGAGAGTGCGTCGAGGGCGACGAGCGGTGCCATCTCCAGCAGTTCGGCAGCGTCGGGATCGAGATGCTCAGACATCGCGTGCCTCCTGCCGTCGTCGAACGATGTGTCGCTGTCCCCCCGAACGCCGCTCCCGGCGGGCGGGTGTCACGTTTCCGCGTGGGCCCGGAGGCAACGGGGCTGCGGCAAGAAGTATGACGTGCGCTGCGGGTGATCGGGGTATCCGGGCCGTCGGCTGAACGACTCCTGGTGGAGTCGGGCGCCGGTGGCGTGCAGCGAGAAATTGGCCATCGCCACCGGCGGCAGCGCCGCGTCCGTACCGGGCCTGGCGCTCGCGACGTCAGTCTGGGACCCGTGTGTCATGCCACCTGTTCGGATCCACCGGCGAGGCGGATGGGTCGGGGGAGGTCAGCGCGACGTTCGGTGGGTCACATCCGCACCGGCGTACCGCCGGGAATCTGCTGATCGGTCGGGACGATCTCGGCACCCAGCGGGAGCAGCGACACCGGAACCATCTTGAAACTCGCGATGCCGAGGGGGATGCCGATGATCGTCAGGCACATCGCCAGGCCGGTCGTGATGTGACCGATCGCGAGCCAGAGGCCGGCCACGATGATCCAGATGACGTTGCCGATCGTCGATGCCACACCCGCGGTCGGCTTGCGGATCACGGTTCGTCCGAAGGGCCAGAGCGCGTAGCTAGCCATCCGGAACGAGGCGATGCCGAAGGGGATGGTGATGATGAGGATGCAGCAGATGATGCCCGCGACGACGTAGCCGATCGCCATCCACAGTCCGCACAGGACGAGCCAGATGACGTTGAGGATGGTCTTCATTCCTCCATTGTCCATGTGGTGCCGGCCGGTGGGCACAAATGCGAGACGCAGGAGAGCACCCGCGGGCCGGCACGACACTACGATGACGTCGTGGGTGGACGGCCGGGGCGTGCGCGGGAGGCGTTGTGGGCGGTGCTCGCCACCGTGGTGCTCGTCATCCGCATCCTGGCGACCATCGCGCTCGTGCTGTTCGTGATCGGCTGGGCGGTCGCGGCGATCCGCGATTCACTCGACAACGTGTTCTTGTGGCCGTCGATCGGTGCGGGCGTCGCACTCCTCGTCAGCACCTATGTCTACGGTCACCTCCGCGCGCGCTATCCGCGGCACAACGGGTGGATCCCGTGAGTGGTGCTGACCCCCTTGCTCCCTGAGCTGCGCGCGGAGTCCCGCCCCGGCTCGCTGAGTTGCGAATCTTGTGCTCCCTAATCCGAAGAGTTAGGTGAGGTGGCTGCTCAGGCCGCTCCGCGGGGTGTGATGGTGACGTCGTATCCGAGTTGGTGGAGCTCGTTGAGGGCGCGGTTTTTGGTGCGTTCGGGGTGGCGTTGCTGGTGGTAGTCGGCGCCGGGTTCGTCGTAGACGACGTTGTCGGTGAGCATGATCCAGACCACGGTGAGCAGGCTGTGTTCGAGCGCGACGATCGCTTTGGGTTTGCCGCGCGAGCGCACCAGACGCCGGTATTTGGTGTTGAGGAAAGTGCCTTTGTGACTGGCGATCGACAACGCTGCAGCCCCGAGAGCACCTTTGAGGTAACGGTTCCCCGGACGGGTTTTCACGTTTTTGACCCGTCCCGCGGACTGGTGCTGGCCTGGGCACACCCCTGCCCAGGAGGCCAGATGTCCTGGTGTGGGGAACTGGGACATGTCCGCGCCGGTCTCGGCGATGATCACATCGGCGGTGGTGGTGGAGATGCCCGGGATGGTGCAGATCAGGTCGCGCTTGGCCTGAAAGGGCGCCATCACCGTCTCGATGCGTTCGGTCAACGCCTCGATTCGGGTGGTGTGTTCGTCGATGAAGTCCAAATGCAACTCGACCAAGAACGCGTGATGGTCGGTGAAGCGGCCCTGCAACGCCTGGGTCAACAGCGGGATCTTGCGTCGTAGCAAGGCCACCGACATCTCCGCCAACTCGGCGGGATCGCGTTCGCCTCGGACCAGAGCGCGCAGCATCCGACGTGCCGAGACCCCGTTGATGTCGGAGGCGACCACCGACAGTTTGATCCCGGCGTCTTCGAGGACTTTCTCCAGACGCTGGATTTCGCGGCTGCGTTCGCGGGTGATCGCGGTGCGGGTCCGGGTCAGATCACGCAACCGTCGGATCGGTTCGGGTGGCACGAACGAGGCACGCAATAACCCGTGCGCGGCCAACTGCGCCAGCCACGCCGCATCCGACACATCAGTTTTGCGGCCCGGGAGGTTCTTGGCGTCGTGGGCGTTGACCAACATCACCTCGAACGGGGCATCTTCGAGGAGGTAGTAGAACGGTTTCCAATAGTCGCCGGTGGCTTCCATGACCACACACGTCACCTGCTCGGCGATCAGATAGTCCCGCAGCCGCAGAATCTCGCCGCACATCGACGACCAGGTCGTTGTGTCCTGCACGGTCTTTCGTCCCGGACTAGCCAGGCGGACACAGACTTTCACATCCGATTTGGAGACATCCATCCCGGCGCATCGGGAATGCAGCACTTCCAT

Protein sequences of DBSCAN-SWA_1

>NZ_CP016594|75574:168115|130756_132196_+|WP_033206535.1|DBSCAN-SWA
MTALDAATPSAPGPGHSGPQAEAELELIPESAKTHDVRGQFWIWAGANIAPINWVLGALGVTMGLGLWETVAVLVVGNAIGMTIFGVFVVIGQRTGVTGMVLSRAVFGRRGAYVPAAVQALVCMGWCAVNTWIVLDLVMALLGEMGLVDPDLDNNAARIVVAAVIMGMQVTIAWFGYRVISAFERWTVPPTVAILLVMTVVAWVGLDVDWGQTTAPGLTGSAHIGAITAVMTAIGIGWGLTWIGYAGDYSRFVSRDVPSRRLFLASALGQFIPVVWLGVLGASLATLSDSADPGEIIVDAYGVLALPVLLLVIHGPLATNILNIYTCTVSTQALDIRVDRRVLNLIIGVVAMAVVVYFVLNSDFATTIDFWLVSIVGWLSPWGSVVLVHWFLIARQQIDAESLFAAPADSVLPMVRPTALVALALGVTATWMFMYGMLPALQGPVAVALGGIDLSWLAGAVVAGTSYWTMEKLTAPRAA
>NZ_CP016594|75574:168115|164778_165666_-|WP_004022227.1|DBSCAN-SWA
MSEHLDPDAAELLEMAPLVALDALSDDELRDVQERVAGAPHDVRALFDKQVRATREALAAMSKTTATPPPPTLRDRILSAARADAGLDAPDLAEPAGASASGPVVSGASDHPMPQQDPASAGTDVGQPESAAGSPATGADDRRRSRRWTYLAAAAVLAVAIGAAGWVIGQSSSPEPEVRPLASPAEQVFSAEDLRSTGGPVATGNVTVYLAKSADTGVLVMDSVPPPQPGTVYQMWLIGPDGARSAGTMTDKDVEPVTTAVLSGINSASTLAFTVEPPGGSDRPTTTPVAQLSLT
>NZ_CP016594|75574:168115|115765_117157_-|WP_004020620.1|DBSCAN-SWA
MSITTAIAEKAQSMIPIDLQIRGAHVYDKTRRIVTRTDGKKIFTETPIPPVEDVELTDIDLSNPFLYRQGMWRSYFERVRNEAPVHFQPRSPFGPFWSVTRHADIIAVDKNHEAFSAEPFIIIGRPPRFMDIAMFIAMDPPRHDKQRAAVQGVVAPKNLREMEGLIRSRVREVVEELPLDEPFDWVQTVSVELTARMLATLLDYPYEQRHKLVQWSDLATSMEQANGGPSDNDKVFREMVAMAQGLSALWRDKAARTAAGEETGFDLITMLQSNEDTKNLLDNSPMEFLGNLVLLIVGGNDTTRNSMSGGVLALNEFPEQFEKLKANPDLIPNAVSEIIRWQTPLAYMRRVAKKDVMLNGQFIRAGDKVVMWYASGNRDERVFDRPDELIIDRSNARNHIAFGFGVHRCMGNRLAELQLRILWEELLERFDDIEVVGDPEYVQSNFVRGISKMMVRLTPKPET
>NZ_CP016594|75574:168115|102019_102772_+|WP_004021760.1|DBSCAN-SWA
MSVVRRISAAPVKVQRRVRDARSTRWDDHRAVVKAELVDAAIRAIEKFGDAVSMDDFAEEAGASKPKLYRHFGDRAGLYSAVAARLGSMMWESAQSTLLSGQADSTVDELFRSAVSAYVSLVDEHPAVVRFLMTNHMFQYSESGEGGAADQLRSAMEIISDEFARGLREVDAEESPVAVAVASILGAGLSATQWWIDHGRQNGMSRDMFAAHLCQTSWGIIDGAAATVGVRFHRDRPLGDPGFATRLDAV
>NZ_CP016594|75574:168115|119659_120640_-|WP_110117389.1|DBSCAN-SWA
MREIAKVDGSLGHLYGYHLVCAAFIELLGSPEQRDATYRRVAQGSWTGNALSENNSHILDWKVRATPRDDGGYVLNGTKHFCSGALGSDLLLVFGVAQDDDSPERSGIITAVIPTDRGGVRPNNDWKALGMRRTDSGTTDFKDVQVLPHEVLGAPNSVITDFFGYRRASLFGPLVQLIFSHVYIGIAAEALDSAREYTLEHARPWTPAGVSEATQDPYVVRTFGELAIKLQGADAAARDASHAVQRIWEKGDALAPADRASLMVQVSGVKVLATEAGLSIGSRIFEVIGARGTHPRLGLDRFWRNIRTHSLHDPVAYKIADVGQYF
>NZ_CP016594|75574:168115|134364_134907_+|WP_004019701.1|DBSCAN-SWA
MGKIHVHEFITLDGSYEDPSFTMPYGFADGMGELLGSFMSDCTGILLGRNTFEMFAPAWAHRTVDDDPGAPFFNDTTKYVVSSTLDDAAAWQNSEIIGAYDADRIRELKKDRDLYISGSGTLVRALLRDKLIDELHLLVYPVVLGSGARLFDGLADLPLTLVGTDVFDNGVVHLSYSSTD
>NZ_CP016594|75574:168115|151771_152434_+|WP_004019682.1|DBSCAN-SWA
MTSNGVTPTDATSPLASLTRKPERAADRALLDALLDEAKVGTLGTVVDGLPWSVPMLFARDGDSILLHGSTGAGALRHVAAGAPVTFTVFVLDGLVVADTLFDHSANYRSAVIRGVLEVSGDAQTDLEVLSDKLIPGRVAEVRPTTRKELAATVALRLPIADGQWIAKARTGGPGGGSTDWTGVVPVRTVYDAPLTHSGGTPPESVRALVGPSPSTEARE
>NZ_CP016594|75574:168115|126685_126997_+|WP_004020510.1|transposase|DBSCAN-SWA
MPKKIDPEVRSRALRLLEAHGGEYTSLTAAAEAIAKQVGVGGETVRRWAVQAQVDAGARSGTTSKESAEIKRLKAENKQLREDVAILKAATTFFAGELDRRNR
>NZ_CP016594|75574:168115|154289_155093_+|WP_004019679.1|DBSCAN-SWA
MPEPLSGIVTEALRRVRRSSGVPLAFAGVLSGPSNLRLQHFAGSTVGALNGVSVDVGHGLGGKVVSLNRPMVVDDYLRTPRITHRYNTIIEREGLRAMMAAPVIVDRSPVAVLYGALHTPDPIGGRMLDVLAMEARTVEHEIVASRARLEHAAQDEAEMRDRMTAAYARLRSLADTVDDARLADELAAITEVLVAANPVAQTQVDLTGREQDVISLAALGYSNARIAETLGVTVYTVKGYMKDAMRKLGASSRLEAVVTARSAGLLP
>NZ_CP016594|75574:168115|118634_119111_-|WP_004020623.1|DBSCAN-SWA
MSAPTKLPAHSPSCMGCGPENASGLQLEVYRDGDRVFADHSFTTKHSGGPGLAHGGAISAACDDIMGFTLWIAGTPAVTRTLTVKYRRPVPLHVPVRLTACIDEDADHILHIGASGTVDGETYFSATGEFVKVDLMHFARYADTSTVDSFFVNLLRAD
>NZ_CP016594|75574:168115|91514_92255_-|WP_014928955.1|transposase|DBSCAN-SWA
MEFVAAHRDEHGVDPICAALRDTSAQIAPSTVRAHLSPQKTEAPRVVRDRELLTQVRAVHADNLGVYGARKVHAQLRRQGHSAARCTVERLMKADGLQGIARLKTRKTTRSEGAETPRPADRVNRQFTAAAPNALWVADLTYIRTHSGWVYAAFVLDVFSRMVVGWQVSTTMHTDLALDALNMGLWARSRAGHDVAGLIHHSDRGVQGGFNWSSQHHDHGGVCGGYGGLESEDQRCGGRCSSAVAC
>NZ_CP016594|75574:168115|124825_126124_-|WP_068970850.1|DBSCAN-SWA
MTQDTRSAATNDFLSGAYYKKIAQTLERGKFDLLFLPDALAVEDSYGHDLQTGVGLGGQGAIALEPATVVATMAAVTDRLGLGATISTTYYPPFHVARILATLDNLSDGRVSWNIVTSLNDSEAKNFGIDAHLEHDTRYDRADEFVEVVRKLWNSWDDDALLLDKICGRFADPKKVHYVDHRGDWFDVRGPLQIPPSSQREPVLLQAGLSPRGRRFAGQWADAVFSISPTLEMMQRTYQDIKGQVSAAGRNPDATKVFTAVMPILGETEAIARDRLEYINGLVHPEVGLSTLSSHSGIDLSAFPLDAKYSDIVASLGDAHIPTMLHMFSTVASDGEDLTLADLGKRYGTNVGFVPQWGGTPTQIADRLVEYFDARAADGFIISAAYLPGVYEDFVDQVVPLLQERGVFRDEYEGSTLRDHLGLELPSGAAAL
>NZ_CP016594|75574:168115|78886_79363_-|WP_004023289.1|DBSCAN-SWA
MTPEARLPAHSSQCMGCGSSNPHGLQLEVYRSGERVYADHTFDEKHLGAPGLAHGGAISAACDDIMGFTLWIARTPAVTRTLTVEYRRPVPLHTPIRLTAWIDHESDRLLHIAAAGSFDEQTYFTSSGVFVKVDVAHFRRYADVSTIDDFFANFTRSD
>NZ_CP016594|75574:168115|159753_160386_+|WP_004022232.1|DBSCAN-SWA
MSGELRIDNVVTSGTFSLDGGTWDVDNNVWLVGDDDEVIIIDAAHSAKPILDGVGNRTVTAIVLTHGHNDHVTVAPELSEATGAPILLHPGDDMLWNDTHPDVAHQDLEDGQRISVGGTELTVINTPGHSPGSSVIHLPEAKVLFSGDTLFQGGPGATGRSYSSFPTIIASITEKIFTLDPETKVYTGHGDGTTVGDEAPHLEEWIKRGS
>NZ_CP016594|75574:168115|132320_133280_+|WP_004019703.1|DBSCAN-SWA
MATVQTATGSIDSADLGNVLVHEHVFIVNEEFRQNYQDDWDEDEKVAEAIRDLTELKELGIDTILDPTVLGLGRYIPRIQRIAEQIDLNIVVATGLYTYNDIPFQFHYAGPGMLFDVPEPLVTLFTKDLTEGIADTGVRAAFLKCAIESQGLTPGVERVMRAVGQTSAQTGAPITVHTDPHSQSGLVAQKVLAEEGADLTKVVIGHSGDSVDLDYLMKLADAGSVLGMDRFGLDLLLPFDERVNTVAELCKRGYADRMALAHDAACFIDWFDHEAKKQALPKWNYRHISEEVLPALRERGVSEADITTMLVDVPRRYFE
>NZ_CP016594|75574:168115|101028_101934_+|WP_004021761.1|DBSCAN-SWA
MTSEFASASRGSRDLEVLSSDGTKLFAQEFGPGRDAPLLVFSHGWACQGRFWRPQVEQFAATHRVVVYDQRGHGLSDRGRVPFSAKLLADDMEAVVRAVATPADKAVVVGHSMGGMSIMSWAAEYPASVSELARGVVLASTGPSQLVDRSTLLKVPRQLRPRLERAFAASLAVAGPEMQGTRLSRRLIRYGTLGPGATAEVVDECADIVLRCPPQVRGMWGSVLATIDVSKGVDSLEVPATVIVGDADRLTPATHSVDLAARLGRKGVLFEFTLLDKVGHMSNLEAVEDFNSAVARLDKSA
>NZ_CP016594|75574:168115|82272_83286_+|WP_004023293.1|DBSCAN-SWA
MTLRSLTPTIIKIVAFIALIGVLSYVIIAILQPTNEGSPSSQRSAVFADASGLKPRDGVRLAGVKVGYVTAVDLEGSTAIVRFQLDDGVAITPATTAAVRYQNLLGQRYVELINAGQGADQDSITQVALEKTVPSFDVSTLFNSFKPVFDTLNTAEINELQSNLLRVAQGDGRGIAPVMKQVANITDYGNQRSEIITNIVTSLGQVSDQLMGRSAELVELIDKLGSIVDAFSRVSDRLRASLREVNRSMAKTVLAGEQIESTYDTSFAAIFQRLVREPGDTEGLLNGAVLLKPLLDALAATSNATPPPSAAGCARGVLDLPRTVQIALMGQRLVVCQ
>NZ_CP016594|75574:168115|141968_143492_-|WP_004019691.1|DBSCAN-SWA
MAPRLSSTNSIDGILRRSAARHPDRTALVFDDRDYTYRQLDDAVSAAAAGLLARGLEQGDRVAAYGTNSDAYVIGFLACCRAGLVHVPINYALRGDELRYLVVQSGARAVLVDPALSERVEEIRGDLADVEAVVPLRDADDSLLASAASEPPAAFDSRASGDDLAQLLYTSGTTSKPKGAMMSHAALISEYVSSVIALDFTAEDNPLIAMPLYHSAGMHVFMLPYLSVGATVRLMATPDIPEILRRVEADRIGSLFLAPTVWVPLANHPDLATSDLSSLRKAQYGASIMPVTVLNRLRDQFPGMQFYNCFGQSEIGPLATVLRPEEHEDRPSSCGRPVFFVETRVVDTDGNDVEPGVPGEILYRSPQLCRGYWDNPAATEEAFRDGWFHSGDLVTRDAEGFITVVDRIKDVINTGGILVASREVEDTVYTHEAVSEVAVIGEPDEKWIEAITAVVVVRDGRSVTEEELIEHVRSRIAPFKVPKKVRFVDELPRNQSGKLLKRELRSQ
>NZ_CP016594|75574:168115|117603_118629_+|WP_004020622.1|DBSCAN-SWA
MSLVESGMPPLAFAQLLDSGALGAAETRAFERIMAREGVDLAVVIARQGQVPVRWFHEVYPAMDSQQGFRLGVAFAEHAQLTSFGPISLPLVSAGSVVEVVQLLQFLPLISTALSTEFQHGDSGLTIALAGRTDSAGTDCFAVTYGGLAVLRLVDMLAGAVPSVELHLTCQAPADLIAVGEIGHRIVFNAPAAFVHIPAAVLYDVCRFSDPVAYRIGIAELRRVYEQRRPSSYTQLVRAQFDADPARADGARIAAELSISVSTLKRRLNAEGTTLRRLRQQFVQERATARLLDPGIGVGEIAAELGYSDAASFSHAFTRWVGCSPTRFRRAPANRQAAPGI
>NZ_CP016594|75574:168115|87371_88061_+|WP_004023298.1|DBSCAN-SWA
MTAQDNGPESKDSSAEDKLTAASDKADRSDATGATESATSQDGPAPDEASPPTSDARHRWRSARVQAVAAGAFVVALAVLAGLFAYLYIDMREAKTSAENAATQRAQAAQAASDYTTKSLTYSYQNTGAFFTEVKENASDALVKRYDDVEPTLTQIMEQAKVQASGRVLATSVTGSASENRGEYTVLVFATQKTQNVQNPQPSELPTLLKVVVLKTENGWQIQDYGPAE
>NZ_CP016594|75574:168115|130500_130758_-|WP_143953045.1|DBSCAN-SWA
MESVQEVSAPDWAGCVRAWRATMRSASMVVAPPVARYLQNVRTPRVRNGQNVTPSAFLAQPTGLSGLLALTDLEGDALFGGVGDA
>NZ_CP016594|75574:168115|103785_106827_+|WP_033206569.1|DBSCAN-SWA
MVVQRPSGGRLAARRLAERSEYSTTLGRLARFTLAHRFLVIGAWVAVGIVLAILFPQLETVVRQQSVDPIPAGVPSFQALDQMGGAFGEKGAKTTVFVTMENPNGFTDVARERYDMLVLQLRENFDDVQSVRDLLSDPTTAGQALSEDGQAWYLPVGVTGTLGGPTATHAVETVRQTAQRVFDGTGTTVHVTGPTATFSDQIVSAESDLVVITLATVALIAIILLIVYRSLFTALVPLLVIGVSLGVGRGILSALGELGMPVSQFTVAFMTVILLGAGVDYSVFFISRYHERLRQDATTEVALVDATATIGRVILASAATVALAFLAMVFGQLSVFSTLGPACAIAILIGFLATVTLLPPVLLWAARFGWGAPRRDLTRKYWNRVAVLVVRRPVPLLALTLVGLIVLSVFATGIQITFDDREGQPATTDSNEGYALLDRHFPQDVTITEFLVVDAPIDLRTASGLADLEQMASRVSQIPGVTRVIGVTRPTGDKLEQAELSWQNGQIGNRLAGAVDDGQNRRGDLEQLRTGAFQLADGLTQLDTQVRTNLAPLAGILDQASTAGQQIQQYQPLLRQLAASAPALDRASQNAPQLAALTRQTSAALATVTSILPILDNAPWCTQVPQCAALRAQTRNLDALLSNGTLDQIATLSTQLAQLDTPISTVTDQLTSTVNSLGSTLGSISSQDLPGKLTQLQTGISQLAAGSRQLAAGVSALIDSNLQQLAGMAALATQLQTSARETAGTNSATGFYLPPQANADRRFVDVARQFVSPDGHTVRYAIQTSFDPYSTEAMQLADTITDVALAARPNTTLQDSNIATAGFPAINADLQRLLTEDFRLLALATLTIVGLILILLLRALIAPLYLLGTVILNYTAALGIGVLIFQHILKTDIAWPVPLLAFIVLVAVGADYNMLLISRLREESQNNIRIGVLRTVTNTGSVITSAGLIFAASMFGLMAGSISIMTQVGLIIGIGLLLDTFIVRTIVVPTIATLVGRASWWPSTRTDTHPASR
>NZ_CP016594|75574:168115|88090_89731_+|WP_004023299.1|DBSCAN-SWA
MKNTMQEVPMTVSSILRHVATNHTDRQVITYSASDSARYATYGDLEERCARLANALRRVGVVGDDRVATMLWNNQEHLEAYAAVPAMGAVLHTLNIRLSPAQLQFIANHAEDKVIIVDGSLVPLLAAVLPGLATVRVVFVTGDGDTSPLDGHGVTVMRYHDALAAESPMFSWVDPDERSAAGMCYTSGTTGDPKGVVYSHRSVFLHSIAACTGNALAIAEADRVLPVVPMFHASAWGLPYASLMAGADLLMPDRYLQAAPLADLIQQHRPTKAGAVPTIWNDLLQYGIANPGVDLSSIDLVACGGAPVPQSLIEGFADRFGVQIIQAWGMTETSPLAAVSRPPAGISPTKEMSYRKRQGRAICGVEMRLIDEGGLPVPRDDKSVGELEVRGPWVTGSYYRLEDAERFRDGWLRTGDVGHISPDGYLTLTDRSKDVIKSGGEWISSVELENWIMSHPDVAEAAVVAMPDPRWQETALAVVVPVPGRKVSADTLHEWCLRNCPEEIPHWWIPKNWTFVEQVPRTSVGKFDKKVLRAKHEQGELPVVSN
>NZ_CP016594|75574:168115|146206_147685_-|WP_004019686.1|DBSCAN-SWA
MTDSDTDTTQPSVRDMIIIGAGLSGIDCAYRFTEQNPGADYLILERRERMGGTWDLFRYPGVRSDSDIYSLSYPFEPWRKPRALAHGTDIREYIEDTAAKYSITDHIRFGQHVLTADWDSTTDTWTLGVEVGEDRRRETYRARFVIFATGYYDYDNPYTPRFAGADDFTGQIVHPQHWPEDLDYRGKKIVVIGSGATAVSLIPSLAEQAEHVTMLQRSPSYIFSSKQKQYLAPLVQKLLPPHAAHKVIRTRYAAQTAAIVHLTHRFPKLGRKMIRSNVVANLPEDYPVDLHFNPTYNPWDQRMCMVPDADLFADIAEGTVEMVTDHIDRFDASGVTLTSGRHLDADIIVTATGLQLLGFGGTRLRVDGAEVKPHDRFVFKSYLIEDVPNLAWSVGYTNASWTLRADMTARAVADLVKYMRTNGYTHAYPHLGSEVMGSRPLWDLKAGYVERSPEALPKSGTRGHWQVRHNYYRDAIDHRINKVEDSMVFGRV
>NZ_CP016594|75574:168115|103072_103699_+|WP_004021759.1|DBSCAN-SWA
METIDFDDVDPRRVRSRQRLLDAAVTLLNSGGVEAVTVEAVTRLSRVARTTLYRHFESSTDLVAAAFERLLPQAETPETTTSIRDDLLKLMQRQAELIEHAPLQLTTLAWLAMLPEQPRQSGQSDGDQNALAPLRRRVVEQYREPFDRVLTSDVATAELDNFDLTMAVTQLAGPLIFAKLTGIRSMTVGDLEQLVDDFLMAHRRHQTS
>NZ_CP016594|75574:168115|114569_115769_-|WP_014928948.1|DBSCAN-SWA
MSTDRVVIVGASHAGAQLAANLRKEKWAGAILLIGDEGRLPYQRPPLSKAYLAGDCHLDDVAIRSRQFYDKQRIELVDGTVTSIDRAERTVTLGNNDAVSYSKLALCTGARARALPVPGADLPGVHYLRTATDVEAIRAAAVPGSRVVIVGGGYIGLETAASLRTLGVEVTVLEAAGRVLERVTAPVVSEFFDRIHREKGVEVRTDAMVEGFRGDERVDGVVLSGGETLAADLVIVGVGVIPNTELAAAAGIDVENGILVDDRARTSDPDIVAAGDCANHRIERYGRRVRLECVSATTEHAKIAAATICDNTTGRAALPWFWSDQYDLKLQIAGLNTGYDEVLVSGNPAHGRDFTCYYLTAGELIAADCVNRPADFVTAKRAIAQRAPIVRSELIGAAP
>NZ_CP016594|75574:168115|139345_139777_-|WP_004019695.1|DBSCAN-SWA
MQAEHPDAVIVDDNGLSAGRALMTVVSAAHEQLVILTVEGSIDVLTAPQLSEAVSQALSGQPDGLIIDLTTTEFLASAGMAALVAAHEAIAPRGMFGVVAAGPATTRPLTVMGLDQTMVLYPTLNDAVTAMTTTEGLADRPAG
>NZ_CP016594|75574:168115|113901_114573_-|WP_004020618.1|DBSCAN-SWA
MTTSPTNAVSPAALTGSRFLDIEHATVATFTREAVGNATTDKDKAGRLFTAVRDAIRYDPYTVSNDPEHYRASHVIESGRGYCVPKAVVLTAAFRAAGIPARLGFADVRNHLQTGALRELMGTDVFVYHGYSHVYIDGRWLKATPAFNSELCARFGVAPIDFTGDSDALLHAHSADGSTHMEYVRERGVYNDLPLDNILVALKEAYGPLILTQRATSLDAFHA
>NZ_CP016594|75574:168115|138853_139339_-|WP_004019696.1|DBSCAN-SWA
MVRISSAHPRPEDSDGGLTLSVTATPESAHLFRQHFTRWLDATLDVDAERRSDIVLAVYEAVANAAEHAYAADAPSPAAQSPAAQSSATRSRAIGVRAHVTRDESLEVTVTDSGRWKSDASSSPYRGRGLALISALSDASDVTSGPDGTSVTLRWHQRLSV
>NZ_CP016594|75574:168115|156915_157803_+|WP_004022235.1|DBSCAN-SWA
MRTLSATLLTAALLGTLLVAAPATSTAVPAETCGTELRPADRERIVELGTYDQDSRDLPLVQLRRNVAKLYGIVDILTDRRDRRGLFALGLAAVERDAVMPLQNNPRVFQTPRWAPVISLELLNRFLDAVRGEFGGGPVAPQWRHYFDMADDCAVPGQRVAMAGYNSHITVDLAYATADARATPSNARDFFFIVDAIAAHGNSIVTETLREYGVDLGPIFRFYIVGEGLDRVVGAGRATGPMLRAADVGYNVLTFRNGLALQDVRAAPGARGDVNALWNTGETALTAFQRVGLVR
>NZ_CP016594|75574:168115|163175_164693_+|WP_004022228.1|DBSCAN-SWA
MKLTDVVQTSADVARDRSRTRKTAVLAEALSATSDAELPIVVAWLSGEIPQGRLGVGWRSLSKLIAAPAESPTLEVAAVDAALGELASASGPGSTKRRGEIIASLFAASTEAEQKFLVALLTGELRQGALAGVMTDAIAKVTGQDLVLVRRANMLTGSLPETAALARFGAEALAAVGLEVGRAVEPMLATPADDLDSALALLGPDLIVDYKLDGARIQVHRKGTEVSVFTRTLRNVTANVPDLVSVIAALPCDSVILDGETLMLSDDGRPRSFQDTMSRFGSGPTAAGEPERLLKPFFFDCLHLDGTDLIDRPLSERLAAIDSIAPQLRIPAVTRPSVEEARNHFDAAMADGHEGVMVKSLDGLYVAGRRGKAWQKVKPTHTFDLVVLGAEWGSGRRSGWLSNLHLGARDPETGELVMVGKTFKGLTDELLRWQTEEFPKHETHRDSYTIHLRPEIVVEIELDGAQRSSRYPGGVALRFARVVRYRPDKTAAQADSIEAIRALLK
>NZ_CP016594|75574:168115|135025_136357_-|WP_004019700.1|DBSCAN-SWA
MSPDFDAVLEAAWRDFADTLAVRVPRLLPGQSLAIVEAAAGGWRRRMTFAVTGTLGSTERLRCTISAGDLTWTDKDRWMRQATYIVDRGWCRLEGRSAFCFEVDPLRFADLADAAVRALREVWGVIHPSFVSIGDPSFARHHSPLPADDLDAERDQARSSESSRVVGEDPDDTVRITDADTLRFTAPPRFVDAPAEGGVIPQSKDHLVELVRAAMTAAGRPAVVSPRKAIFLRSTGTSLLRPTRDARSLEIVTILSSSVPAPSLLGMVVAEFSPRWPEVAVVVRNGLVYAQRRIDVAVFSPANLDAALRRWDDFARSARGDMIRRLGSQPKLDHRRRGDRLPGALLSLLRVNQKLDNKLSPTTVLAACHRDRERVHEFFDICAAEMREWMDNLTTARNAELGAEEIALCEAEHQAYARVARLLLSAMDLADGASEPSQRPPAP
>NZ_CP016594|75574:168115|97531_99052_+|WP_004021764.1|DBSCAN-SWA
MASSTTRRASRATAKTDSTNDPISTKILIIGSGFSGLGMAAQLRRRGYSDFLILEKASSVGGTWRDNTYPGCACDVPSLMYSYSFESRGSWSKVWSSQPEIERYLQDVADKRGVTQKIHFGQKLVSGYWSESESRWHLRTESGREYIAQFVVSGVGALHIPNFPEISGIEDFKGEAFHSAQWDHSVDLEGKRVAVIGTGASAIQFVPFVQKEAMSLKVFQRTPAWVLPRKNFSVPPALRTLLSKLPIARRIARWSVYWGAESLAFGLNGHSNLMRPIEKVARWNIERSISDPALRKKLTPSYRIGCKRILGSNDYYPALAAPNTTVISDRIEKVTADSIISSDGVEHLVDVIIYATGFHVTDGFDQLALKGATGEDLPSHWHQTGINTHLGITTEGFPNLFFLLGPNTGLGHNSVVFMIEQQIKYIMKAIDTVESRGAEKVDVRPSVQEQFNTDIQRKLAKGVWTNGGCTSWYLDSQGVNRTVWPGFTWQYWRATKDFEPAEYDIA
>NZ_CP016594|75574:168115|136444_137257_-|WP_004019699.1|DBSCAN-SWA
MAITTDRGALTFTFPELGRDARLHVTFQRTLRTPDPVGGCGSAGGDGALRLAQGSPDGDAHATIPMWQSEATWLDFSSPHLHPFLVMVGVDGVNAISGEVFTGVPDFDAGDYLEVPTQPSLASHRGPAGGGFDDQQFLAPSTHTVGDGGRLGTLVQLAVIPMRADAWARRRRHRPSAPGTCVLCDISRAERERAHPRLAAPLVTGPLESVDTWHPTISDAATVRIVNSIAWRSMTGEPVPRAAPTSADYAAHSLPWHPVFDETVEHSAPR
>NZ_CP016594|75574:168115|158668_159757_+|WP_004022233.1|DBSCAN-SWA
MSQTVKGVISRSKKAPTEVVDVVIPDPGARDVVVAIKACGVCHTDLAYREGGINDEYPFLLGHEAAGVVESVGSDVTHVEVGDFVVLNWRAVCGQCRACKRGRPWYCFDTFNASVPMTLTDGTELTPALGIGAFAEKTLIHELQCTKVNPDTDPAVAGLLGCGVMAGIGAAMNTGNVGRGDSVAVIGCGGVGDAAIAGARLAGATTIIAIDRDASKLEWATDLGATHTIDGSKVDDVIAAVQELTDGNGADVVIDAVGRPETYKQAFYARDLAGVVVLVGVPTPEMTLEMPLVDFFSRGGALKSSWYGDCLPERDFPMLIDLYEQGRLPLDKFVTERIGINDVQAAFSAMEAGKVLRSVVEL
>NZ_CP016594|75574:168115|95929_96268_-|WP_004021766.1|DBSCAN-SWA
MSDDHDLDYSGEGTLVCRGAEIHVEAKIKGYFQPLNGLYTWYGRIQKNDELDGLLKGARAIAVFTTPEGRAECVVGDPDFWGRYRISGKSTPPYHLPTTLEEVENMVEHHHK
>NZ_CP016594|75574:168115|81238_82276_+|WP_004023292.1|DBSCAN-SWA
MAVFHDPSGREPSHGNLALRGVALLILGAIAAYLLISDANGDFSDHTSLTINTDAIGDGLKGGSDVKYLGFTVGEVSSIAVRDRGAAVKINLTGSGNDLVLRQGMTVNYTSSNALGPTALEIVDPGQGPPIGSGGSVYVSRLQSEQTSVSTLVRKISTLVEALDQPSFEAVVRFIVEDSQAMADSGRLVLQIAQLTRDVQKRPVGEDLGIAANLSTGVADFMTPFVPGVLKNVDIADFFATQQNIDRTKSNLGDTGKVLFGGLGGLLDKNYPALSSLLDVGLDLARPVARSASGLVRTVYTIPQILDGIDKALPKFNERVQLQLALVVQTSPALQGALRMGGATR
>NZ_CP016594|75574:168115|160468_160909_-|WP_004022231.1|DBSCAN-SWA
MADDDRVSSAEPDLGALLGRLIPHLISLEEPILRAAGLSMWEYAIVGEIAATPAVSQRALSERTGRDPTRLGKHLDELQRRGIVSRERSGSHRQWTVSITSEGHALHERVQAEIRAVEDELLHGAMSDSQATTFRRLLRVLVASVS
>NZ_CP016594|75574:168115|99141_99969_+|WP_033206566.1|DBSCAN-SWA
MITGAASGIGRSLALQLAERGAALALSDIDEMHLKETAELCRTTHGATVTAAVLDVADRAAFQDYADGVRSESGHVDMVFNNAGVALGVDVVDMSWEDFDWLMGINFGGVVNGSKAFLPHLIASGDGHLINTSSVFGLIGIPSQSAYNAAKFGVRGFTEALRQEMKISRYPVTVTCVHPGGVKTNIVNNARGVSAMGADTATVASLFDRIARSTPDKAAATILKGMDKKRARVLIGADARGFDFVARVIGPRYQDIAAPLTRAGYAVARRQGILK
>NZ_CP016594|75574:168115|92814_95847_-|WP_004021767.1|DBSCAN-SWA
MVSSSPIRTRPSRGGEKLGEYSPTLERVAWFTLRRKGIVTLVWLGAAIGLGLLFPQLESVIREQSVDPIPAGVPSFQTLDRMGASFDERGAKTTVFVVMENSAGLSDNTRDRYHVLVDTLRADDRHVIAVRDLLSDPLTASQALSKDKQAWYLPVGVAGTLGGPDTAEAVAAVREIAESIFRDSGTTVRVTGPPATFSDQLAVGESDLVLITVATVLLIAVILLIVYRSVFTALMPLLVVGMSLAVGRGVLSGLGELGMPVSQFTSMFMTVIIFGAGVDYSVFLISRYHEGIRAGYSPDVAIAHANATIGRVVLASAGTVALAFLAMAFAKLSVFNTLGPACAIAIAFAFLATVTLLPLVLSFAAKKGAGLPRRDLTRDYWRRVGVMVIRRPVPLLAISVVVLIGLAMVAATIQITYDDREGQPPDTGSNEGYALLNRHFPKDIIISEFLVVESENDMRTAQGLADLDQLASRVAQIPGVTRVIGVTRPTGEKLEQAQLSWQNDQIGTKITEETGDGQARKGDLAVLKAGSEQLAGGLALLEDQISSNLAPLSGLLDEVSSFGPQLDEYRPLVNQLANAAPRLRQFSKQAPELSQLARRAQSAADAVAPALSALDNPWCQQIAQCSALRAQMADIRALADDQSLGRVADFAAQLGRVSAPGSTNIAQLQRSLQTLDSALQAIGGQDLGNRLSQLESGVGALADGARQLSNGVGALVDSNLQLLSGLAQVAAQLRAPAREVGDSDSATGFYLPADAFKDQQFSQVARQFISSDGKTVRYAVQTAYDPYSADAMTLANELSSVAENAMPNTTLEGGRASVAGFPAINADVQRLLSYDFKLLGIATLLIVGLILMLLLRAVVAPVYLLATVVLNYMAALGIGVLVLQHILGAGIAWPVPLVSFIVLVAVGADYNMLLVSRLREETRWSVRVGVMRTVAYTGSVITSAGLIFAASMFGLMVGSIDVMVQIGFIIGVGLLLDTFLVRTLVVPALAVLLGTASWWPGDIDRFRLAP
>NZ_CP016594|75574:168115|92257_92575_-|WP_004022138.1|transposase|DBSCAN-SWA
MAAPRKYSEELKDRATRMACEARRDPDSSRGAIKRIADQLGVHPEALRNWVRQAEIDGGVRPGTTSEDADRIAALERENRELRRANTILKQASAFFAAEIDRPQR
>NZ_CP016594|75574:168115|117183_117504_-|WP_004020621.1|DBSCAN-SWA
MATITYVTHDGEDYPAPVMPGRSLMQTAVDQAIPGIDGDCGGEAACGTCHVVVDSAWIDTVGHSTDVEEGMLSMHPEREANSRLSCQMTAREEWDGLTVHLPEFQL
>NZ_CP016594|75574:168115|158040_158316_-|WP_004022234.1|DBSCAN-SWA
MAENKKDPGPSVKDDELYEKLRDEGNSKEKSARIANAAANSSRSDVGKSGGRSGSYEDWTVDELKKRAKELDLSGYSDLKKDELIEKLRDH
>NZ_CP016594|75574:168115|84271_85333_+|WP_004023295.1|DBSCAN-SWA
MLTERMRRHLIPIATIVTLAVVIGGVGIDYATADDDTRSLCAEFSDASGLYEGNSVAMLGKKVGRVVGIHEEGQKGVRVDMRIDKTVPLPADVGATLVSTSIVTERQIEFTHPYRGGEYYKSAECIPLEKTRTPLGISQTLDAISTLSDELVKDDGRNTDAILQALTLVSKNMEGTQGDISGILQDSATLINDPTRRDSQIRRIVANLATLTGVATENSTEVTQLFDNFVGAIEVIVAFGQTFGAATEYAGTFVPILSRLSSDFGPPIFSLGDAAVPLLSQAGKQENILASVAARTADLIVEHPDAKSILRAFAISVPLQALKNACAPPSVKDVCATGNEAATIANLIGGQPR
>NZ_CP016594|75574:168115|166876_168115_-|WP_004022872.1|transposase|DBSCAN-SWA
MEVLHSRCAGMDVSKSDVKVCVRLASPGRKTVQDTTTWSSMCGEILRLRDYLIAEQVTCVVMEATGDYWKPFYYLLEDAPFEVMLVNAHDAKNLPGRKTDVSDAAWLAQLAAHGLLRASFVPPEPIRRLRDLTRTRTAITRERSREIQRLEKVLEDAGIKLSVVASDINGVSARRMLRALVRGERDPAELAEMSVALLRRKIPLLTQALQGRFTDHHAFLVELHLDFIDEHTTRIEALTERIETVMAPFQAKRDLICTIPGISTTTADVIIAETGADMSQFPTPGHLASWAGVCPGQHQSAGRVKNVKTRPGNRYLKGALGAAALSIASHKGTFLNTKYRRLVRSRGKPKAIVALEHSLLTVVWIMLTDNVVYDEPGADYHQQRHPERTKNRALNELHQLGYDVTITPRGAA
>NZ_CP016594|75574:168115|119370_119634_+|WP_004020624.1|DBSCAN-SWA
MRQQSVDPIPAGVPSFQSFDRMGTAFGEKGAKTTAFIAMENRGGLTPTVRARYDELVQELRGTTADVASARDLVGGSPMCVVELVRM
>NZ_CP016594|75574:168115|143541_144066_-|WP_081486980.1|DBSCAN-SWA
MASLVMFAPSAHADRVINGHLVGGKIEQAYASTGGFFKWGVPTGPERVAAKRGRFQTFSRDTSFYWHPAADGGTAHQVGGAIRSRWQQAGAERGALGYPVSNEYRSGSGRSNDFQGGVVTWSKTGGAQIVWGQIRQKWENTGGAGGYFGVPLGGEYRTGGRFAQDFLNGTIFWP
>NZ_CP016594|75574:168115|121034_122234_-|WP_101819295.1|transposase|DBSCAN-SWA
MRPLSLDEPSGRYLSFAEREEIALLRAQDRGVREIARWIGRSPATISRELRRNAATRSGKLEYRALVAQWKAQQAAKRPKTAKLVAHVELREYVQDRLAGVVRRPDGTIAAGPTPPPWKGLNKPHRANRRWSLAWSPEQISQRLKVDFPDDESMRISHEAIYQSLFIEGRGALKRELVACLRTGRALREPRARSRNKPQGHVTSDVVFSQRPAEAEDRAVPGHWEGDLIIGTGRSAIGTIVERRSRATLLVHLPRQQGWGEQPPVKNGPALGGYGAIAMNAGLTASIAALPQQLRKTLTWDRGKELSAHAQFAMDTGTQVFFADPHSPWQRPSNENTNGVLRQYFPKGTDLSRWSAEDLEAIAYTLNNRPRKVLGWKTPAEVFGEQLHSLQQPSVASTD
>NZ_CP016594|75574:168115|75574_76666_-|WP_068884350.1|transposase|DBSCAN-SWA
MATRGPRAVDIVLTDDERRELEGWARRRTTASGLAMRSRIVLAAADGGSNTEVAQRLGLNRSTVRRWRGRFVEHRCEGLLDEPRPGRPRTVDDEQIKNLITATLETTPKNATHWSTRAMAEHLDMSQSTVSRVWRAFGLAPHKQDSWKLSRDPLFTEKVRDVVGLYMNPPERALVLCVDEKTQIQALDRTQPIFPMLPGTPQRASHDYVRNGTSSLYAALDIASGKVIGSLHSRHRATEFIGFLRKIDAEVPDELDVHLVMDNASTHKTPAVKRWLTSHPRFVVHFTPTSSSWMNLVERWFAELTTKKLQRSPHRTVRALNADIRAWIETWNDNPRPYVWVKTADQILDSIAHYCTRINDSEH
>NZ_CP016594|75574:168115|133301_134099_-|WP_004019702.1|DBSCAN-SWA
MDVAGKVAIVTGGGAGIGAAIAHALVDAGAKVVVTDLDESGALAVADSLGDSTTAIGGDASSDEHIDAAVRLAENTFGPVDLYFANAGVGVGGGVDTAEAVWDLTLDVNLRAHIRAARRLVPDWVERGTGYFVSTASAAGLLTQIGNAPYSVTKHAAVGFAEWLNITHGDDGIRVSCLCPMGVDTKLLRPEGDSATEEQRLMQRAVETAGTVLTPGAVAAIVLDAVADERFLILPHPEVLEMYRQKGADYDRWLRGMRRYQSSLR
>NZ_CP016594|75574:168115|166016_166424_-|WP_004022226.1|DBSCAN-SWA
MKTILNVIWLVLCGLWMAIGYVVAGIICCILIITIPFGIASFRMASYALWPFGRTVIRKPTAGVASTIGNVIWIIVAGLWLAIGHITTGLAMCLTIIGIPLGIASFKMVPVSLLPLGAEIVPTDQQIPGGTPVRM
>NZ_CP016594|75574:168115|161720_163088_+|WP_004022229.1|DBSCAN-SWA
MSDSAVRNIDHPDQAPVPRSRIVIASMIGTSIEFFDFYIYATAAVLVFPVLFFPKGDDTAALLSSFATFGLAFVARPIGSILFGHFGDRVGRKATLVGSLLTMGIATFVIGLLPTYDSVGYLAPALLALMRFCQGLGLGGEWSGAALLATETAEKGKRAWAAMWPQLGAPIGFFFANGTFLLLMLALDFDAASADPDHAFMTWGWRIPFLASAIMVAVGLYVRLKLTETPVFAKAVADGKKVKAPLAEVVKTSWRPLIAGTFIMVATYTLFYIVTTWVISYGTGKVTDESGVKLSISYVDFLQLQLVAVLFFAACVPISGRLADRYGRRAFLIIITAAIIVFGLCFQWLLDPSSMTDGMMLFFLILGMTLMGLTFGPMSAILPELFPTNVRYTGSGIAYNVASILGAAVAPFIATWIVADYGVGWVGVYLAVAACATMIALLSVKETKTVDLTEV
>NZ_CP016594|75574:168115|112776_113835_-|WP_004020617.1|DBSCAN-SWA
MSVSGPSMIDPYPHRMGGHCGSGAMRDLMEWTGLGYDGPPDEGLVFALGGALSLTYIRSKALMPPVYLVGRGPDFEIDLPRRLGGTVEVLATDDPAEGWENLRGEIDQGRPALVWAEIAELPYLRVQLRMSRHDIVVVGYDETQGVAYIADNDREDLQRVPLDALARARRSTSFPEPTRHTLFRINWPQTPPSILEVAAQAFAQSAASLSTPGASTIAGPAEHGSHGLDAASALASDVCSWGALSTDDLEMHLFSLGAFIEKAGTGGGLFRRLLAQGCDEIARLTGDHATAILAANAHHAATSWTAVARAAVQKDHASSERLRSVTTLAAALPEAETTLEASLRKAAASLSG
>NZ_CP016594|75574:168115|141287_141938_+|WP_004019693.1|DBSCAN-SWA
MALQTVDLPAPAEMRSRWAAHAALLAVRGERWAQGAYATPDGWHYDDGGGNWVDVVLVGADRAVLVGHDHEYSETYFREGATYFGESETDLLGGAPPWWEPAIASHLERQRTDGMWIGFVYGFDGRWTRSGYDLADGFTSVGLPFTDDQKTVDALDDLLANWFVELRLAPPADIRARVREIIEPGAEVTAAGLHRILGPAGAHADIPGAVAAAQRF
>NZ_CP016594|75574:168115|120682_120937_-|WP_040527186.1|transposase|DBSCAN-SWA
MAEAFNSLFKAECIRNPVMRPRGGWAGVGEVEIAVAEYVEWFNHRRLHGEIGHVPPVEYESAYWSTHTVTSYRENPVPANAGTN
>NZ_CP016594|75574:168115|161026_161608_+|WP_033206613.1|DBSCAN-SWA
MGTVFEKGRRMDTAALRATTDDVGAHLSEMTVGDMSIPAAATNGDLGDLFVAAVDRNARLTALLAGDELISQRAAPIDRASFPLVADQYGGGFDHRYRRSAGLMVAAFAGVLDTHRVVDLDGTHTTAGALYEHAVRDAFLLTWNIATAIDIRYQPRPDIVRGVIQTMLSHIEDADLATAVDVLVQLSGPHRDK
>NZ_CP016594|75574:168115|147819_150060_+|WP_004019685.1|DBSCAN-SWA
MPMEKHTYCRICEPLCGMIATVEDDRLISLRPDKEHPLSRGFACPKGIAFTEIVNDPDRLRHPLRRRPDGEFEQVSWETALDEIGRRLVEVHQTSGSDSIGWYFGNPATFSTGHVLWTAIFMNLLGTPHVYSAGSQDVNNRFVASHFLYGNPLTAPIPDINRVDYLVIIGANPVVSHGSVMSSPRIREGLNAITARGGSVVVVDPRHTETAREFDWLPITPDTDALFLLSVLHVLFDEDLADRDRLRRQARGVGELETLVAAYAPETTADRTDIDPERVREVARSLARTERAAVYGRVGTSLGRTGTLTTALLDMVNLVAGNLDVPGGSMFGDLGIPGQRLGVSALQRVSSFRWAGRRSRVGDLPQVLGTAPASLMAKEITTPGRGQLRALFVSAGNPVLSVPNGDELRSALDELDLMVSLDIYRNETNARADYILPATTMYEREDFLLPFQALFTTPFKQATEAVIPPQGEAREEWTVINELIGFLARENVLIRSLHAGNRLARRIGRPVTPRGISDLVIRMGLGGDRFGLRRGGLTYRRLVEDHPHGVVVADHLAPGQLSKNVTYLDGRIRLAAPELMSEIGQLGVDADTGYPLRLIGMREIRSENSWQHNAPMLLRGGRSHAARIHPDDATARGLAEGDLATVASRHGRISLPVTITEDIKPGVVAIPHGWGHNGSGGWTQANAAAENDLGAGGVNVNALISSDPADLERLAGMANMTGVPIQVSAMSESRLQSADTVEPARH
>NZ_CP016594|75574:168115|165735_165951_-|WP_033206616.1|DBSCAN-SWA
MTHGSQTDVASARPGTDAALPPVAMANFSLHATGARLHQESFSRRPGYPDHPQRTSYFLPQPRCLRAHAET
>NZ_CP016594|75574:168115|80366_81230_+|WP_014928961.1|DBSCAN-SWA
MTTVPSRRFSAATRPVEAVIAPVVHVPERLGHVATFVIAAVLGIRHVITTYRRQTLLYIQEFAWGRGAVLVGGGTAIVLAILGIAVGASIGIQGYASLDLVGMGSLTGFISSYANTRELAPMIAAIGFAAQAGCRLTAEIGSMRISEEIDALEAMAVRPIPFVVSTRVVASITTVIPLYIVALILGFGAAKLVVTQVHGQSGGTYDFYFDQFLKPQDLAFSLIKVLVFVISVVIIHSYQGYFATGGAEGVGRASGRAIRTSLIVIVVEDMILTLLMWGFDSGVRISG
>NZ_CP016594|75574:168115|99965_101039_+|WP_004021762.1|DBSCAN-SWA
MTVEPDSRPAAAAARSRTLTVSEVIQETKDSVTISFEIPDAMVEEFKHTPGQFITVKIPSDRTGHVARCYSLSSSPHVDDFRLEIGIKRTENGYASNWLCDNAITGMELTVLPPSGHFTAKNLDVDFLFFAGGSGITPVFSLIKSALVCGGGEVTLFYANRDAESIMYGGQLTQIVSEFPERFTVFHWLESAMGIPTPQNVESAIREHRGAQIFTCGPAPFMDLVQKSAEACGVEHSSVHREVFQSLTGDPFDTATMRQLGDDDGVATATVYLNGQSITTEWPRNTPLLDVLLAQGHNAPYSCREGACSACVCKLVEGDVEMAQNHILVEGDVADGERLACQALPLTDSVTVSFDDL
>NZ_CP016594|75574:168115|85329_86373_+|WP_004023296.1|DBSCAN-SWA
MMIYGYLRRVTAAIVTLFVATIALAACSISADNPPTIGGSSARDGYDIEIEFTSALNLPARAKVLSRGIDVGAVTSVAYDGGHALVAARIDKDAQLPEDSRAELRQDTLLGEIYVAILPPAQQSTQGLLRAGSVIPLSRTEPAANVEDVMRGMANVLGGGELDKIHTAISTLNSTFPSDPAQFDALYRTTLRTVSEVSANTDKLDVILQSADRTLKVILADPSGTDRMLTKGGVNFYGLGYSLIDVALLIANLRDFAVSAGRIVDPEYSRIKETVGAIAPVVASIAYSDIYSKDVSDKAARVIRERLIPFVSSPDINVSDVSIDGRELARRDAESFITVLRAIGMMP
>NZ_CP016594|75574:168115|107633_108398_-|WP_004021756.1|DBSCAN-SWA
MSDNQTGKQIEFAARALKMPAIRRCWAELAERARTDNWTHEQYLAAILDRQVSEREANGTMLRISGARFPAVKTLEDFNFDHLPGLRRDVIAHLATSTWIAKSDNVILLGPPGVGKTHLAIALGIKAAHNAYPVLFDTATGWATRLTEAHTTGRLAAELKRLRRYRLIIIDEIGYLPFDSDTANLFFQLIASRYEQGSILITSNMPFGRWGEVFADDVVAAALIDRLVHHAEVIAIDGDSYRTKARRELVNTDQ
>NZ_CP016594|75574:168115|144236_145964_-|WP_004019687.1|DBSCAN-SWA
MTYPPGPPSHPSNPYGPVPPQSDSRRALTLVLGAIVVVLALILAAGIVFVVKARDGDIFVPGLTLTAANDPGIDPFTDPVLVAGAGDLPANVALTGTAGAADLGGRAVNGTDAGLYGSGDAAACDTAALSNRLLADPPAARAWAGVYGIDTADIPHYLNTLTPVVLTTDTWVTNHSYTSGRAVPFQSVLERGTAVYVDSAGVPRAMCSCGNPLAPPAAAPLGGYRLDGQPWEGYKSRSVARIAYNNQHVTAVGKSTTIVPAPPVPDPGAPAGDVLQLLNFLTGQIFSQPAGGLLDLSGFPPPSGPLPTPAALNTPFEAATDEDAEHNGLLAAGNPAAAPALEKRAEEHDGLPEGAPSTDSSAPDSSGPDSAAPDTPGPGPDSPAPDAPVPASDVPVPEEPGYEAPGSELPGPATEPGAPGPDQPAETPTTPTSFSGSGEVVGSFSFVDAGLSVGCTVPGGPALGTITLSCTDGVTRSVAGSALHRPGVSGSTTGTGVWTLTLTAVGASRSVTVRSANWIAAPPAAPASEPPASDGSADPATPAEELPDDTTTTTTTESPPPADAPADPEAPAGTP
>NZ_CP016594|75574:168115|152616_154194_-|WP_004019681.1|DBSCAN-SWA
MTQATTKPVDMVDRWLGIYGAPDADAASLLVDGHDPDAIAFTVIEVEQTGDQQSGGVRPVTTDITYGELAERSKRLAAALAEMGVGRGDTVGVLMGKREELVVSLLAIARLGAIYIPLFTAFATPAIEMRLAAGDAKVVITEPSQADKLAGIDGITTVIAGEQFEELISSHEPVTESVAVGGDGTLILLFTSGTTGAPKGVPVPVKALASFVAYMHFGLDVRADDVFWNAADPGWAYGLYYGVLGPLAAGRRNLLLHAGFTPELTAKILGELGVTNFAAAPTVYRALSKDSRISGFSLRRASSAGEPLTPDVIDWALRAIGTEVRDHYGQTEHGMFINNHWHESVHETLVPGSMGQPMPGFAAGIVDGQIAIDVPASPLMWFEGYLDAPEKTKQRFSPDGRWYLTGDTGRVDDEGRYFFTARDDDVIIMAGYRIGPFDVESVLITHPSVVDVAVVGRPDELRGEVLEAFVVTADGVEGSDALEAELQQLVKTQFAAHAYPRTVHFVDALPKTPSGKIQRFLLRQR
>NZ_CP016594|75574:168115|122403_123144_-|WP_014928955.1|transposase|DBSCAN-SWA
MEFVAAHRDEHGVDPICAALRDTSAQIAPSTVRAHLSPQKTEAPRVVRDRELLTQVRAVHADNLGVYGARKVHAQLRRQGHSAARCTVERLMKADGLQGIARLKTRKTTRSEGAETPRPADRVNRQFTAAAPNALWVADLTYIRTHSGWVYAAFVLDVFSRMVVGWQVSTTMHTDLALDALNMGLWARSRAGHDVAGLIHHSDRGVQGGFNWSSQHHDHGGVCGGYGGLESEDQRCGGRCSSAVAC
>NZ_CP016594|75574:168115|96401_97370_+|WP_004021765.1|DBSCAN-SWA
MTVQDVQMNPDFSKEGMARVNGRKPVDMERSAGRLLRSSAEKFYDAEIDIDWESPWEEGKCFLPEHRVSLYGTRLWDKMTEEQRRELGRHEIVSILSFGIYAENLLSSALLRMSAKGALTDQKSLYALTEIGDESRHSTMFARLINKTGVPPYKLPKGFLSFAKILHFVPLGPSVSGATLLIEEILDRAQREAMNDPSMQPQLRQLMKIHVLEEARHITFARLEMIEGMQRRRKATRAWHRGVLAVIANLAYPLLINPKVYPAVGISRWRGVWAQQTSPNYRTNLQFMSEPMIRFFHEAGMLEGKFTMAMWRATRSLPDDLR
>NZ_CP016594|75574:168115|139938_141138_-|WP_033206526.1|DBSCAN-SWA
MRTVTRWHRKVLAFAACAAVVIGSSGAAGTLAAGPAIASPSTLGDTGSVVSSRPLAPQFWVPGSADATVLTYVTTDTFGNKALSTGTVFIPEGTAPPGGWPVISWAHGTSGIGDDCAPSVRGPGLPERDLPYLAKWMQQGYAIVASDYAGLGTPGLHAYLDGRTTAHNVVDMVRAGREVSASLPAAQRLSRSWAAVGQSQGGGAAIYTARYATQFGGPALDYRGAVGTGTPAYIERLVQIAGPGVPPVAITPALTAYLSYITAGLRYAHPELGIDRILTPTGRKYVALAETQCVGEFEEQLRGVSVGDYFSAPLTSLPNFSATLADYLGMPEKGFDKPFFMGHGLLDTDVPYPTTAAYAATLAANGQPVTFRTYPSDHSGTLVRSQADTIPFLDRLFGK
>NZ_CP016594|75574:168115|108404_109703_-|WP_165629285.1|transposase|DBSCAN-SWA
MISVEQWAEIRRLHRSEGVPIREIARRLGVARNTVRAALASDTAPKYSRPATGSAVDAFEPQIRALLREYPTMPATVIAERVGWTRSLTVLKDRVRAIRPEFRGVDPADRVIYQPGGCSQWDLWFPDYRIPLSHNQFAMLPVLVMTLAFSRYRSAVMIPSRQGGDILTGMWLLLSQLGGVTRKLVWDREAAIGPKGTPTALAAGFVGTLGTRLELAPPRDPEYKGMVERNNRFFESSFLPGRQFSSPADFTAQFDRWLADHANTRVVRAIGDRRPCDVFAEDLEQMTGLPPTAPHIGLSSRVRLGRDYYVRVAGNDYSVHPSVIGRFVDITADLQQVRILCGEVTVADHARSWANHVTIADPQHVRAAKELRRDYRRQDLANRARNAARIRAHPDGHEVPIRALPDYDELFGVNFATPPQAHPPTTSTSIER
>NZ_CP016594|75574:168115|155242_156460_-|WP_068884355.1|transposase|DBSCAN-SWA
MIFVGNDWASDHHDVCVMDEHGTTLATRRIPENAAGATTMHELIARYAQEPGEVVIGIETDHGMWVTALVAAGYQVYAINPLSVSRYRDRHHVGGTKSDKADAKTLADLVRTDRHNHRLVAADTVAADAITVMARTHQNLVWARSAQQNVLRSQLGAYYPAAVDAFGGDLAHKDCLAVLRRAPTPRQGAALSVAAIRSALKKGGRQRNTDTRARDIQHALRGGGHLGAPEALTAAYAATVTATVEMLAALNTQIIQLETTMAQSFRAHPDAEIYLSMPGVGDITGARMLGEFGDDPERYATAKSRRNYAGTSPRTIASGKGHVVLARHIRNTRLNAAALCMAQSALTGSPGARVYYDSLRDQKKSHTQALRAVANRLIGILHGCLTHRTHYNEHTAWNHRTHLAA
>NZ_CP016594|75574:168115|123734_124829_-|WP_004022072.1|DBSCAN-SWA
MTDTSSAVHTLAYSNCPVPNALLVGRESQLLAEAGINLDVLGGPLGSLHFTYDHPAYTRFGGEIPPLVSEGLRAPGRTRLLGVTLFEGKLGFYAADPTLTAPEQLAGHRVGVSASAIRILRGDLGDYRQLDPWRQTLVALGTWEARALQHTLRHSGVTVNDIELVPIETAGVDLPQDRLSASASVNGSDLFPAVGAHQAQVFAGGTVDALFSWLPWSAEFEDLTGVRPLRDLSLDRTSHYASVWTISAQLVDKNPSLVQHLVDTVVRAGSWARDHLTETVAIHARNLGVSETAVTRGFGEHFTDNLVPTLDHDALTVLAATQRYLVDHDLVDKAIDLTDWSAPEFLQTSLRTCAAGTSAIGEYE
>NZ_CP016594|75574:168115|127942_129142_+|WP_101819295.1|transposase|DBSCAN-SWA
MRPLSLDEPSGRYLSFAEREEIALLRAQDRGVREIARWIGRSPATISRELRRNAATRSGKLEYRALVAQWKAQQAAKRPKTAKLVAHVELREYVQDRLAGVVRRPDGTIAAGPTPPPWKGLNKPHRANRRWSLAWSPEQISQRLKVDFPDDESMRISHEAIYQSLFIEGRGALKRELVACLRTGRALREPRARSRNKPQGHVTSDVVFSQRPAEAEDRAVPGHWEGDLIIGTGRSAIGTIVERRSRATLLVHLPRQQGWGEQPPVKNGPALGGYGAIAMNAGLTASIAALPQQLRKTLTWDRGKELSAHAQFAMDTGTQVFFADPHSPWQRPSNENTNGVLRQYFPKGTDLSRWSAEDLEAIAYTLNNRPRKVLGWKTPAEVFGEQLHSLQQPSVASTD
>NZ_CP016594|75574:168115|86369_87326_+|WP_004023297.1|DBSCAN-SWA
MIRSTLVSLVALVLVLLVGATYLIIDVARVNPFRTDYAISAILESSGGLLDTSPVMLEGVPVGKVTSIRVTGNQLAVDMSIDSDYKIPRGSVMTIQNLSVAGEQYINFIPPGTTTSEYLRSGDLVPAGAIRVSQSVPQVLPKMSAVADALDPASIQSINETISAAVDGRQKDLDTIGDMMHRLVDFVGDDGAVRTTADNAEFLLGLMSNVGGVLSTASVRTPDAVDGLARIQRAFIVFTSTSYDKWPPILKLVEKLSGYIQILQPDIVAITRAVKPATAKVADTYIDFGSIGDLLARTFPASHRGQAQIPIAVTPSPR
>NZ_CP016594|75574:168115|127077_127773_+|WP_157781276.1|integrase,transposase|DBSCAN-SWA
MIAARTYRASRTRTPAARTVSDAHVVDAVRTVVWRTDDDGRRKMTPEGLYGRVKMRAHLHRTTLPGVSYGAVDRAMKVLGHNGIRRSKGVRTTVRSADGVRAEDLVNRQFSAVEPNRVWVTDFTYCRTWAGWVYVVFIIDVFSRRIVAWHASTSKTVELVTVPLRMALWQRKREGHPVKAAELIHHSDAGSQGGFNWSSQHHDHGGVCGGYGGLESEDQRCGGRCSSAVAC
>NZ_CP016594|75574:168115|90145_91345_-|WP_101819295.1|transposase|DBSCAN-SWA
MRPLSLDEPSGRYLSFAEREEIALLRAQDRGVREIARWIGRSPATISRELRRNAATRSGKLEYRALVAQWKAQQAAKRPKTAKLVAHVELREYVQDRLAGVVRRPDGTIAAGPTPPPWKGLNKPHRANRRWSLAWSPEQISQRLKVDFPDDESMRISHEAIYQSLFIEGRGALKRELVACLRTGRALREPRARSRNKPQGHVTSDVVFSQRPAEAEDRAVPGHWEGDLIIGTGRSAIGTIVERRSRATLLVHLPRQQGWGEQPPVKNGPALGGYGAIAMNAGLTASIAALPQQLRKTLTWDRGKELSAHAQFAMDTGTQVFFADPHSPWQRPSNENTNGVLRQYFPKGTDLSRWSAEDLEAIAYTLNNRPRKVLGWKTPAEVFGEQLHSLQQPSVASTD
>NZ_CP016594|75574:168115|79621_80356_+|WP_033206584.1|DBSCAN-SWA
MAGQALRWVAVDIATGRFPFREAVSQTWFVIVVTTLPAILVAVPFGVIVSVQVGSLTQQVGATSIAGAAGGLGIIQQGAPIVTALLLGGAAGSAIASDLGARTIREEIAAMETLGLNPIRRVVAPRFVSVLITAPLLCMLIVFTGLLAGYAISVDVQGITPGSYVASFASFASITDIVVALCKSLVFGLVVVTIACHRGLSTKGGPKGVATSVNATVVLGVVACFVINVFITQLTTMFVPQTIG
>NZ_CP016594|75574:168115|123146_123464_-|WP_004022138.1|transposase|DBSCAN-SWA
MAAPRKYSEELKDRATRMACEARRDPDSSRGAIKRIADQLGVHPEALRNWVRQAEIDGGVRPGTTSEDADRIAALERENRELRRANTILKQASAFFAAEIDRPQR
>NZ_CP016594|75574:168115|83282_84278_+|WP_004023294.1|DBSCAN-SWA
MTRFFGKRPHHRPQRRRDLILAGVVTMVTVAGLVAAGAVYISPPGQTIYSAELVNTGGLEAGDQVRIAGIRKGKVASVDLTGTFITVRFRLDDSIAVRSDATANVRLLTPIGGRVLDLDPGSGPSAIDGAIPLVQTGSTYDISSTLETSTPVFRDVRGVDLRRTAALLQDAFSDGNTNIPDALQNASSLMDLLERQYAQLDKTVALSDEYVAALANRKQVLVDFLRQLSFLARTLGPDIANVQSGFDYLRRLFKLLTRPLVAYRDGIEPSVQQFKILLNKVSAQMPAYQDALAQVDQITRRLSILLNAPQVGPASPEPTVRVCIPIGDNKC
>NZ_CP016594|75574:168115|150946_151528_-|WP_004019683.1|DBSCAN-SWA
MGTYTPAEVSVEVTGEKLDLLTLLQDQRNMLKITARNLSDADARKQTTVSTLTIGALIKHLAHGEEGAAKVITERDENAEFDMSQAMTEYVMSDDETIAGWLAEYDRAALELDRVIADAENLDELIPQPTAPWAPEREWSSIRMMIIHLIRETAHHCGHADIIREALDGQTTMGAVSEGQDWAEGWADQDWAQ
>NZ_CP016594|75574:168115|150141_150744_-|WP_033206541.1|DBSCAN-SWA
MAGCSSDDSDTSSETTGAATESSAMMSESAMADPAANLVGPGCAAYAEANPSGPASVNGMSSVPVATAAATNPELTTLTQALSGQLNPEVNLVKTLNEGEFTVFAPTDDAFAKLPPETVEQLKTDAPLLNKILTYHVVEGQAAPDKIVGEHTTLEGQQVTVTGSGDNLKVNESGVVCGGVTTSNAQVYLIDTVLMPPAGE
>NZ_CP016594|75574:168115|137400_138570_-|WP_004019697.1|DBSCAN-SWA
MTDFTVDSNIDDAWRTFALHVGDRLSHLEPGETLTIQQDPMIPEGPHGTLRFTITGSRRLRCTIDDTDLHPTPEYFAEHVAMLASLGWRRLRNGTHIFEVGRRRVDQLAHVTVLTLRQVWEVVHPAFLDHSPAARPEPRIEVAVQPFDADHLRALLVGSLEDLTGCRIQTDADGDIALPTKPVSSWLSPRSDAPRLEFFARLAGDITDRRRAADIVAAQPTMGSAVRVHLLENEVFATLTVECAVFHPHNLSSALAEWFSFLADCAPSVIAKVGEDTPLTARNDGRLPDALQTLLELDPDGRSLSAREVAKICRYNQADILSYIHTSEEQHLTWRRSAVDAAAASDSVQADACRHEADTWKATTHNLRAALRVVVLSDDDTADSSSSAK
>NZ_CP016594|75574:168115|166514_166769_+|WP_033206618.1|DBSCAN-SWA
MGGRPGRAREALWAVLATVVLVIRILATIALVLFVIGWAVAAIRDSLDNVFLWPSIGAGVALLVSTYVYGHLRARYPRHNGWIP

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_068884350.1|75574_76666_-|transposase	IS630 family transposase	NA	NA	NA	NA
WP_004023289.1|78886_79363_-	PaaI family thioesterase	NA	NA	NA	NA
WP_033206584.1|79621_80356_+	ABC transporter permease	NA	NA	NA	NA
WP_014928961.1|80366_81230_+	ABC transporter permease	NA	NA	NA	NA
WP_004023292.1|81238_82276_+	MCE family protein	NA	NA	NA	NA
WP_004023293.1|82272_83286_+	MCE family protein	NA	NA	NA	NA
WP_004023294.1|83282_84278_+	MCE family protein	NA	NA	NA	NA
WP_004023295.1|84271_85333_+	MCE family protein	NA	NA	NA	NA
WP_004023296.1|85329_86373_+	MCE family protein	NA	NA	NA	NA
WP_004023297.1|86369_87326_+	MCE family protein	NA	NA	NA	NA
WP_004023298.1|87371_88061_+	hypothetical protein	NA	NA	NA	NA
WP_004023299.1|88090_89731_+	long-chain fatty acid--CoA ligase	A0A1V0SBX8	Catovirus	6.3e-18	24.3
WP_101819295.1|90145_91345_-|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	3.8e-36	31.2
WP_014928955.1|91514_92255_-|transposase	IS3 family transposase	A0A1B3AZE5	Gordonia_phage	5.2e-113	100.0
WP_004022138.1|92257_92575_-|transposase	transposase	A0A1B3AZF8	Gordonia_phage	1.4e-51	100.0
WP_004021767.1|92814_95847_-	RND family transporter	NA	NA	NA	NA
WP_004021766.1|95929_96268_-	DUF4873 domain-containing protein	NA	NA	NA	NA
WP_004021765.1|96401_97370_+	diiron oxygenase	NA	NA	NA	NA
WP_004021764.1|97531_99052_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_033206566.1|99141_99969_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_004021762.1|99965_101039_+	ferredoxin--NADP reductase	NA	NA	NA	NA
WP_004021761.1|101028_101934_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_004021760.1|102019_102772_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_004021759.1|103072_103699_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_033206569.1|103785_106827_+	MMPL family transporter	NA	NA	NA	NA
WP_004021756.1|107633_108398_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.9e-49	42.9
WP_165629285.1|108404_109703_-|transposase	IS21 family transposase	NA	NA	NA	NA
WP_004020617.1|112776_113835_-	BtrH N-terminal domain-containing protein	NA	NA	NA	NA
WP_004020618.1|113901_114573_-	transglutaminase domain-containing protein	NA	NA	NA	NA
WP_014928948.1|114569_115769_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_004020620.1|115765_117157_-	cytochrome P450	NA	NA	NA	NA
WP_004020621.1|117183_117504_-	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_004020622.1|117603_118629_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_004020623.1|118634_119111_-	PaaI family thioesterase	NA	NA	NA	NA
WP_004020624.1|119370_119634_+	MMPL family transporter	NA	NA	NA	NA
WP_110117389.1|119659_120640_-	dibenzothiophene desulfurization protein C	NA	NA	NA	NA
WP_040527186.1|120682_120937_-|transposase	IS3 family transposase	A0A1B3AZE5	Gordonia_phage	2.7e-45	100.0
121026:121085	attL	NA	NA	NA	NA
WP_101819295.1|121034_122234_-|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	3.8e-36	31.2
WP_014928955.1|122403_123144_-|transposase	IS3 family transposase	A0A1B3AZE5	Gordonia_phage	5.2e-113	100.0
WP_004022138.1|123146_123464_-|transposase	transposase	A0A1B3AZF8	Gordonia_phage	1.4e-51	100.0
WP_004022072.1|123734_124829_-	hypothetical protein	NA	NA	NA	NA
WP_068970850.1|124825_126124_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_004020510.1|126685_126997_+|transposase	IS3 family transposase	NA	NA	NA	NA
WP_157781276.1|127077_127773_+|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_101819295.1|127942_129142_+|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	3.8e-36	31.2
WP_143953045.1|130500_130758_-	hypothetical protein	NA	NA	NA	NA
129092:130469	attR	NA	NA	NA	NA
WP_033206535.1|130756_132196_+	cytosine permease	NA	NA	NA	NA
WP_004019703.1|132320_133280_+	phosphotriesterase	NA	NA	NA	NA
WP_004019702.1|133301_134099_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_004019701.1|134364_134907_+	deaminase	NA	NA	NA	NA
WP_004019700.1|135025_136357_-	hypothetical protein	NA	NA	NA	NA
WP_004019699.1|136444_137257_-	hypothetical protein	NA	NA	NA	NA
WP_004019697.1|137400_138570_-	hypothetical protein	NA	NA	NA	NA
WP_004019696.1|138853_139339_-	ATP-binding protein	NA	NA	NA	NA
WP_004019695.1|139345_139777_-	STAS domain-containing protein	NA	NA	NA	NA
WP_033206526.1|139938_141138_-	prolyl oligopeptidase family serine peptidase	NA	NA	NA	NA
WP_004019693.1|141287_141938_+	hypothetical protein	NA	NA	NA	NA
WP_004019691.1|141968_143492_-	AMP-binding protein	A0A2K9L3I8	Tupanvirus	1.9e-16	21.4
WP_081486980.1|143541_144066_-	lysozyme	NA	NA	NA	NA
WP_004019687.1|144236_145964_-	hypothetical protein	NA	NA	NA	NA
WP_004019686.1|146206_147685_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_004019685.1|147819_150060_+	molybdopterin-dependent oxidoreductase	NA	NA	NA	NA
WP_033206541.1|150141_150744_-	fasciclin domain-containing protein	NA	NA	NA	NA
WP_004019683.1|150946_151528_-	DinB family protein	NA	NA	NA	NA
WP_004019682.1|151771_152434_+	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_004019681.1|152616_154194_-	AMP-binding protein	A0A2H4PQU7	Staphylococcus_phage	4.9e-68	37.4
WP_004019679.1|154289_155093_+	GAF domain-containing protein	NA	NA	NA	NA
WP_068884355.1|155242_156460_-|transposase	IS110 family transposase	NA	NA	NA	NA
WP_004022235.1|156915_157803_+	hypothetical protein	NA	NA	NA	NA
WP_004022234.1|158040_158316_-	hypothetical protein	NA	NA	NA	NA
WP_004022233.1|158668_159757_+	S-(hydroxymethyl)mycothiol dehydrogenase	E3SJ82	Synechococcus_phage	1.5e-31	30.6
WP_004022232.1|159753_160386_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_004022231.1|160468_160909_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_033206613.1|161026_161608_+	hypothetical protein	NA	NA	NA	NA
WP_004022229.1|161720_163088_+	MHS family MFS transporter	NA	NA	NA	NA
WP_004022228.1|163175_164693_+	ATP-dependent DNA ligase	A0A1V0S7R5	Shearwaterpox_virus	5.1e-22	28.3
WP_004022227.1|164778_165666_-	anti-sigma factor	NA	NA	NA	NA
WP_033206616.1|165735_165951_-	hypothetical protein	NA	NA	NA	NA
WP_004022226.1|166016_166424_-	YccF domain-containing protein	NA	NA	NA	NA
WP_033206618.1|166514_166769_+	hypothetical protein	NA	NA	NA	NA
WP_004022872.1|166876_168115_-|transposase	IS110 family transposase	NA	NA	NA	NA

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NZ_CP016594|3761556:3770607|DBSCAN-SWA
GATGCCACATGATTCGCCGTCCAGCGGTCAGACTCCCCCGGACTCTGCCCCGAAGCCTCATCTCGCCGAGCCCCTGCACGCCCTCTGGCGGCCGGGCGTCGGCATGGCGGTGTGGATCGACGGCGATGTGTCCGATCTTTCGCCGCCCCTACGCGACCTCCTCGACGGCCGACGTTTTCGCAGCGAGATCCCCGTCGTCGACGCCGACGATCGACGGCAGTTCGTGCGCGCCGCGACGCTCGGTCTGACGTCGGCGGTCACATTGCTCGACGCATCGCGGTCGGTCCCGGTGGCGGGTGACGTCCGGTGGTACCGGTACCTGCTCGACGGCGCGCGGTCGTTCGTGCGGTCCGGCACGGTGGTGCCGTCGGTGCAGCAGGTGGCCGGCGAGTGGATGGTTCGCTGGGTCGCCGTCGCGACACCGACGTGGCGCAGCTGGCACGCCGTCGTGGTGGGAAGCGCGCCGGACGCGCTGCTGCACAACGGTTCCGCGGCAGCCCTCGACGACTTCCTCACCGAGCTCGTCGACCACGAATGCCGTTCTGCCATTGCGCGTTCCACGGTCCGTCTCGGCGAACCGCGACCCGCGTCACCGATCGTGCGGGCACTGCTCCCCGACGCCGATCCCCGTCCACCCAGCTCGCCCGAACGCCTCGCGGCCGCCGCGGGCGGCTGGTCGAGATGGAATTCCGGCGCGCCACGCGACGATCGTTCGCTGATCTTCCGCCTGCACGAGCCGGAGTACGACGATCTCGCCGAGGGCCAGTGGGACGACGCCTGGGCTGACGACACCTTCGAGGTGCCGAGCCGCACCGAGGTCGCCGAGTCCGCTCGATGGCGACTACAGGTCTGCCGGCGGAGCATCGACGGGCAGGTCGAACCCGTCGCACCGCACCGGCTCGACGCCCACGAGCTCGACGAGCTGACGACCGAACTGGCAACGGCCGTGCGCGAGTTCCCGGATCTCGGCCGGGCCGATCCCGACCGCGGCTCCCTCGACTTCCTGCTGCCGACCGAGGTCGCCGAAGAACTCTTCGCCACCGGCGCGGCGGCGCTCGGAGCAGCCGGCATCCCGGTACTGCTCCCCCGGACGATCGCCGAGGTCCGCCCGAGCCTGACGCTGCGCGCACTCGCCCCGCCCGGTGGCGGTGCGCCGGCGGCGATGGTCGGCCTGCGGGAGATCCGCGAGTTCGAGTGGCGGCTGGCGCTCGGCGACACACCCGACGCCATCACGCTCACCGACGCCGACCTCGACGAGTTGTCCGGGCAGAAGGGCGACCTGGTCCGGGTGCGCGGGGTGTGGATGCGCGCCGAGGGTTCCGCGTTGACCCGGGCCGCCGCGTTCGTCGCCACCCAGCGCGCACTGGCTGCGACCGAACCGCCGAGCGACTTCGGCGAGCTGTTCAACCTCGTCACCGGCGAGTCGGATCGGTTACCCGTTCCGGTCTCGCGCGTCGAGGGCCTGTCGTGGCTCGACGACGTCGCCGACGGCGGCACCCTCCGACCCGAATCCATCACGCCACCAGCGGACCTGGCCGCCACCCTGCGCCCCTACCAGCAGCGGGGGCTGGACTGGCTCGCCCACCTGTCGACGCTCGGGGTCGGAGGTGTGCTGGCCGACGACATGGGCCTGGGCAAGACGCTGCAGGTCATCGCGCTGGAGTGTCATGAGAGGAGCCGTTGGCCCGGTTCGCCCGAGGCCGAGCCCCCGAAGCCGACACTCGTCGTCTGCCCGATGTCACTGGTCGGCAACTGGGCGCGCGAGTTCGCCCGCTTCGCGCCGACACTGCGGGTGGCGATCCACCACGGGCCGTCCCGCGAGTCCGGCGCCGCCTTCGCCGGGATTCGGGACTCCGTCGACGTCGTGGTCACGACCTTCGCGATCGCGGCGCGCGACCACGAGCTGCTGGCGTCCCGGCCCTGGCACCGGATCGTCGTCGACGAGGCGCAACACCTCAAGAATGTGAACACCATTGCGGCCAAAGCGGTTCGGACGGTCCCCGCCGATCACCGTGTCGCCCTCACCGGCACCCCGGTCGAGAACCGACTGGAAGACCTCCGCGCCGTCATCGACCTGGTCAACCCCGGTCTGCTCGGGTCGGCCTCGGTCTTCCGGGCGCGCTACGCCGAACCGATCGAACGAGACCGCGATCCGGCCGCGCTCCGACGACTCTCGGCGATCACCCGCCCCTTCATCCTGCGACGTGAGAAGAGCGACCCGGCGATCGCCGCCGACCTCCCGGAGAAGGCCGACTTCGCCGTTCGGGCCAACCTCACGGTCGAGCAGGCGGCGTTGTACCGCGCGGTGATCGACGAACTGATGGCAGCACTACGGGACAAACAGCAACGGACGCTACGACGCCGCAACGTGCTCGCGGCGCTGACCCGGCTCAAACAGGTGTGCAACCACCCGGCGCACTACCTCGCCGACGGCACCGACCTCGTCCGCGACGGCGAACACCGTTCGGGCAAGGTCGAACTGCTCGCCGACATCGTGTCCACGGTCGCCGACGAGGGCGACCGCGCACTGGTCTTCACCCAGTTCGCCGCCTTCGGCGACATGCTCTCGTCGTGGCTGAGTGCGGAGTTCGGCACCGAGATCCCGCTGCTCCACGGCGGTCTGGGCCGCACCGAACGCGACCGGATGGTCGCCGACTTCCAAGCCGACGACGGGCCACCGGTCCTGCTGGCGACGTTGAAGGCCGGGGGCACCGGCCTCAACCTGACCGCCGCCAACAACGTCATCCACGTCGACCGGTGGTGGAATCCGGCCGTCGAGGACCAGGCCACCGACCGCGCCTACCGGATCGGCCAGGACCAGAAGGTGTCGGTGCATCGGTTCGTCTGTGTCGGCACCATCGAGGAGCGTATCGACGACATGATCGCCAAGAAACGCGAGTTGTCCCGACTGACGGTCGCCGCCGGTGAGAACTGGGTGTCCGACCTCGCCGACGACGAACTCTTCGAGCTGTTCCGGCTGCGCGACGAGGCGGTCAGCGAATGACGGTGCGCAAGAAGGGCACGCAACGCCGAGGCGAGCGCGGCACGATCGCCGTCCGCGGTTACGGCCTCACCTCATGGTCGCGCGGTTTCGTCGACGTCGTCGAGGGCCGCGGCGCCGACGGCGAGTCGGTTGCCGACAGTCGCCGCATCACGAAGGCGCGCAGGTACTTCCGTGATCGCCATGTGCGCGGCCTGCGGATCGGCGCCGGCCAGGTGACCGCTTCGGTCGAAGGCACCCAGCTCGAACCGTTCGACGTCATCCTGAGCACTCGCACCGTCGACACCGCGACGCTCGCGACCCTTCTCCGGGAACGGGGCGCCGTCGACGAACTCATGCTGCTGACACGCGGTGAGCAACCACCGACGCTGGGTGAACTGCTGGTGCCCACCGAGTCCGCCGACGTCGAGACCGACTGCACCTGCCCCGACGAGGCGCCGCGGTGCATCCACGCGCTCGTCACCTGTTACGAGGTGGCCGCCGAGATCGACCGCACCCCGCTGACCCTGCTCACGGTGATGGGTACCGATCTTCGGGCCCTGCTGGCCGAGATCGATTCGCGCCCCGCGGACACGCGGACATCGGACGAGGCCGGGGCACCGGACTCGTTGCGGCCCGACGACTTCTACGGCACCACCTCGACACTGCCACCGCTACCGTCGCCGTCGCGGATGAACCCGCTGACCGCACTCGACGGCGCGGAGCTACGCGCCGCATTGCGCGCGACCGGTGTGGCGCCCGCCGACATCGCCGAGACGATCGACGAACTCGGCGACCTCTACGACCGCCTCACCGCCGGCGATTCGTAGCATCCCGAGGGACTCGAGACTAGAAGTCCCAGTCCTCGTCCTCGGTGTTGACGGCCTTGCCGATGACGTATGAACTGCCCGACCCGGAGAAGAAGTCGTGGTTCTCGTCGGCGTTGGGCGACAGCGCCGACAGAATCGCCGGGTTCACGTCGGTCTCGTCGCGCGGGAACATCGCCTCATAGCCCAGGTTCATCAGGGCCTTGTTCGCGTTGTAGCGCAGGAACTTCTTGACGTCCTCGCTGAGCCCGACCTCGTCGTAGAGCGCCTCGGTGTAGTCGCTCTCATTGTCGTACAGCTCGAACAGCAACTCGAAGGTGTAGTCCTTGAGTTCCTGCCGACGCTCCGGGGTCTCGACCTCGAGCGCCCGCTGGTACTTGTAGCCGATGTAGTACCCGTGGACCGCCTCGTCGCGGATGATGAGACGGATCAGGTCGGCGGTGTTGGTGAGCTTGGCTCGGCTCGACCAGTACATCGGCAGGTAGAAGCCGGAGTAGAACAGGAACGACTCGAGCAGCGTCGAGGCGACCTTGCGCTTCAGTGGGTCGTCGCCACGGTAGTAGTCCATGACGATCTGCGCCTTGCGCTGGAGTTGTTCGTTCTCCTCCGACCAGCGGAACGCCTCGTCGATCTCCTTGGTGGAGCAGAGCGTGGAGAAGATCGAGCTGTAGCTCTTGGCGTGCACCGACTCCATGAACGCGATGTTGGTGAGCACCGCCTCTTCGTGCGGGGTGGTCGCGTCCGGGATCAGCGACACCGCGCCGACCGTGCCCTGGATGGTGTCGAGCAGGGTGAGACCGGTGAACACCCGCATGGTGAGCTGCTTCTCGTACTCGGTGAGCGTGCCCCACGACGGGATGTCGTTGGACACCGGCACCTTCTCGGGCAGCCAGAAGTTGCCGGTGAGGCGATCCCACACCTCGGCGTCCTTCTCGTCGGGCACGCGGTTCCAGTTGATCGCCGAGACCCGGCTGACCAGCTTGATGGGCGCTCCGTCGGCGGGGCTGTGGCTTGCGGTGGAGGTCATGACTCTTCCTCGTCTAACGGGTGGGGTGGGTGCCGGGAGTCTTAGAGGTACTGAAAGTTGTTGTCTCGGAGAGGATCACAACATGCAGCTGACGCAGCCCTCCACCTCGGTCCCCTCCAGCGCGATCTGGCGCAGGCGGATGTAGTAGAGCGTCTTGATCCCCTTGCGCCATGCGTAGATCTGCGCCTTGTTGACGTCGCGCGTGGTGGCGGTGTCCTTGAAGAAGAGCGTCAGGCTCAGACCCTGATCGACGTGCTGCGTGGCCGCGGCATAGGTGTCGATGATCTTCTCGTACCCGATCTCGTACGCATCCTGGTAGTACTCCAGGTTGTCGTTGGTCATGTAGGGCGCCGGGTAGTAGACGCGGCCGATCTTGCCTTCTTTGCGGATCTCGATCTTGGCGGCGACCGGGTGGATCGAGCTCGTCGAGTGGTTGATGTAGCTGATCGAGCCGGTCGGCGGGACGGCCTGCAGGTTCTGGTTGTAGATGCCGTCGCGCTGGACGGCCTCCTTCAGTTCGCGCCAGTCGTCCTGGGTCGGGATGGCGATCCCGGCCTGGCCGAACAGATCCCGCACCTTCTGGGTTTCCGGCTCCCACACCTTGTTCAAGTACTTGTCGAAGAACTCGCCGCTCGCGTACTTCGACTTCTCGAAGCCGGTGAACGCCCGGCCGCGCTCCTTGGCGATCCGGTTCGACGCGCGCAGGGCGTGGAACAGCACCGTGTAGAAGTAGATGTTCGTGAAGTCGATGCCCTCATCGCTGCCGTAGAAGACCCGTTCACGCGCCAGGTATCCGTGCAGGTTCATCTGCCCCAGGCCGATGGCGTGAGAGTTGTTGTTGCCGAACTCGATCGAGGGCACGGAGGTGATCGAGGTCTGGTCGCTCACCGCGGTGAGACCCCGGATCGCGGTCTCGATGGTCTGGCCGATGTCGGGCGAGTCCATCGTCTTGGCGATGTTCAGCGAGCCGAGGTTGCACGAGATGTCCTTGCCCACTTCGGCATACGACAGGTCGTCGTTGAAGGTCGACGGCGTCGACACCTGCAGGATCTCCGAGCACAGGTTGGAGTGGGTGATCTTGCCGTCGATCGGGTTCGCCCGGTTCACCGTGTCCTCGAACATGATGTACGGGTACCCGGACTCGAACTGCAGCTCCGCGAGGGTCTGGAAGAACTCGCGGGCCTTGATCTTGGTCTTGCGGATCCGTCGGTCCTCGACCATCTCGTGGTACTTGTCCGTCACGTTGATGTCGGCGAACGGGACGCCGTAGACGCGTTCGACGTCGTACGGGCTGAACAGGTACATGTCGTCGTTGGCCTTGGCCAGCTCGAACGTGATGTCCGGGATGACCACCCCGAGCGACAGGGTCTTGATGCGGATCTTCTCGTCCGCGTTCTCGCGCTTGGTGTCGAGGAAGCGGTAGATGTCGGGGTGGTGTGCGTGCAGGTACACCGCGCCCGCACCCTGCCGGGCACCGAGCTGGTTGGCGTAGGAGAACGAGTCCTCGAGCAGCTTCATGATCGGGATGACACCCGAACTCTGGTTCTCGATCTTCTTGATCGGCGCGCCGTGCTCACGGATGTTGCTGAGCAGCAACGCAACTCCGCCGCCTCGCTTGGACAGCTGCAACGCCGAGTTGATCGACCGGCCGATCGACTCCATGTTGTCCTCGATGCGCAGCAGGAAGCACGAGACCGGCTCGCCACGCTGCTTCTTGCCGGAGTTGAGGAAGGTGGGCGTCGCCGGCTGGAACCGGCCCGAGATGATCTCGTCGACGAGGTTGCGGGCGAGCGTGGTGTCACCGTCGGCCAGGGTCAGCGCCACCATGCAGACGCGGTCCTCGAAACGCTCGAGGTACCGCTTGCCGTCGAAGGTCTTCAGTGTGTAGCTCGTGTAGTACTTGAACGCCCCGAGGAAGGTCGGGAACCGGAACTTCTTGCCGTAGGCGTGATCGAACAGTTCGTTCACGAACGCCCGGTCGTACTTCGCGAGGACCTCGGGCTCGTAGTAGTTCTCCTCGATGAGGTAGTCGAGCTTCTCGTCGCGATCGTGGAAGAAGACGGTGTTCTGGTTGACGTGCTGCAGGAAGTACTGGTTCGCCGCCTCGCGATCCTTGTCGAACTGGATCTTGCCGTCGGCGTCGTACAGGTTGAGCATCGCGTTGAGCGCGTGGAAGTCGAGCTCTCCGGGATCATGCCCCGCAGGCCCGGGGTGCACGCCCGACTTGCTGGCTGAAGTGGTGTCCGAGACGGCGGCGGTGGGCGACACGACAGATGACTCCTGCGGATAGTGGTGGCTGAGGCCGATGATGGGCACGGTATCGACGGGGTACGACAAAGCCTGGTGACGCGCGAACGTCGGGTCAGGCGGGCGAGGCGCTGAGCGACACACCTGCCGCGAACGCCGGACTCTGGGCGAACTCCGCGAGCCCCGCGCGCACGCGGTCGACGTCGTCGGTGGTGCCCATCAGTTCGAATCGGTACAGGTAGGGCACCCGACACTTTCGTGCGATGACGTCGCCGGCGTAGCAGAACTCCTCACCGAAATTGGTGTTGCCCGCCGCGATCACCCCCCTGATCGACGATCGGTTGTGCTCGTCGTTGAGGAAGCGGATGACCTGCTTGGGGACGTAGCCGCCGGGTTGCCCCGTCGCCTTGCCCCCGCCGTAGGTCGGACAGACCAGGACGTACGGCTCGTCGACACGGAAAACACCGGTCCGATCGAGGAGCGGGATGCGCTCGGCGCGCATGTCCAGCTTCTGGACGAACCGGTGGGTGTTCTCCGATACGGAGGAGAAGTACACGATCAACGGCGATGCGGCTGCCGCCATGTCTCCTCCAAACTGGTCGTTCTCGTGGATCTCGCCCGCGGGGTCATGTCCTGGCGGGCGCTGTCGGTATCAACGCCGTGACCGGCGTGACCATTTCCTCGATGACTGCGGAGATGCGATGCGATCCGGCTTCCCCGTCGGATCGCTGTTCACATCGCCGGTCGGCGGACGTCGCCACCGTCATGGTGACGACCGTCGGATCAGGCAGCGGCAGTGGCGAGCGCCTTGATGCGGTCGGGACGGAAGCCCGACCAGTGCGCGTCGCCGGCGACCACGACGGGCGCCTGCAGGTAGCCGAGCGCCATCACGTAGTCACGCGCCTCGGCATCTTCGCTGATGTCGACGATCTCGTAGGACAGACCCTGCTTGTCGAGGGCCTTGTAGGTGGCATTGCACTGGACGCAGGCCGGCTTCGTGTAGACGGTGATTGACATTCGGAGGTACTCCTCGGGTCGTAGGAATCGCCAGTGACGTGCGGTTTTCCAGCGTGAAGATGGTGACCTGGATCACCATCTCGGCGGCTTTGTCGAGGAGTCGAACTGCTTCTCGTCTTGTGCCTGACTGGTAACGCAAACACTACACCTAGTGGCTGACATTTCTGACCACCACAAGGGGTTGTGAATAACATTGATGGAAGACGTGCAGGTCGGAGCGGTGCACGATCGTAAATCCGGGCGTGTCCGCCGCGTGTTCGGCGTGTCGCTCACAGGTTGTCCCGAGACCGTCCACAACATGTCCACCGCCCATCCACATCAGCACGCGGTCGACCCCCGGACACGACGACGCCGCGCCGGGCTGAGCCGGGCGCGGCGTCGGACGTCGTCGGGTGATCAGGCGCTGACAGCGACCTCGTCGACGAGTCGGGAGACCGAGGCGACGACCTTATCGACGATGGCCGGATCGGTCAGACCACCCTCGGGAAGAGCGGCGACCTGCAGGCCGAGGTCGGCCTCCTCGATGGCACGACCGCCGGCGATGCCGACGGACTTGCGGGTGTCCTCACGGGTCCACGCGCCGCCGTACTGACCGAGGGCCGCGCTCAGGACCGCGACGGGCTTGCCGGTGAGCGCTCCGGTGCCGTAGGGCCGCGACAGCCAGTCGATCGCGTTCTTCAGCGCGGCGGGAATGGTGCCGTTGTACTCCGGGGTGGCGATCAGCACGCCATCGGCCGCCCCGACCACCTGGCGCAGCTTCGCCACGCCGGCGTCGAGCTGATCCTCGATGTCGACATCTTCGCTGTAGAACGGCAGCGAGCCGAGGTCGTCGACGACGGTGATGGAGACCCCCGACGGCGCGTTGTCCGCGGCCACGTGGGCGAGCTGACGGTTCAGGGATGCTGCGCGCAGGCTTCCGACCAGCGCGACCAGTTCGACGACTCGTTCCGACAT

Protein sequences of DBSCAN-SWA_2

>NZ_CP016594|3761556:3770607|3768751_3769219_-|WP_004019250.1|DBSCAN-SWA
MAAAASPLIVYFSSVSENTHRFVQKLDMRAERIPLLDRTGVFRVDEPYVLVCPTYGGGKATGQPGGYVPKQVIRFLNDEHNRSSIRGVIAAGNTNFGEEFCYAGDVIARKCRVPYLYRFELMGTTDDVDRVRAGLAEFAQSPAFAAGVSLSASPA
>NZ_CP016594|3761556:3770607|3761556_3764559_+|WP_004019254.1|DBSCAN-SWA
MPHDSPSSGQTPPDSAPKPHLAEPLHALWRPGVGMAVWIDGDVSDLSPPLRDLLDGRRFRSEIPVVDADDRRQFVRAATLGLTSAVTLLDASRSVPVAGDVRWYRYLLDGARSFVRSGTVVPSVQQVAGEWMVRWVAVATPTWRSWHAVVVGSAPDALLHNGSAAALDDFLTELVDHECRSAIARSTVRLGEPRPASPIVRALLPDADPRPPSSPERLAAAAGGWSRWNSGAPRDDRSLIFRLHEPEYDDLAEGQWDDAWADDTFEVPSRTEVAESARWRLQVCRRSIDGQVEPVAPHRLDAHELDELTTELATAVREFPDLGRADPDRGSLDFLLPTEVAEELFATGAAALGAAGIPVLLPRTIAEVRPSLTLRALAPPGGGAPAAMVGLREIREFEWRLALGDTPDAITLTDADLDELSGQKGDLVRVRGVWMRAEGSALTRAAAFVATQRALAATEPPSDFGELFNLVTGESDRLPVPVSRVEGLSWLDDVADGGTLRPESITPPADLAATLRPYQQRGLDWLAHLSTLGVGGVLADDMGLGKTLQVIALECHERSRWPGSPEAEPPKPTLVVCPMSLVGNWAREFARFAPTLRVAIHHGPSRESGAAFAGIRDSVDVVVTTFAIAARDHELLASRPWHRIVVDEAQHLKNVNTIAAKAVRTVPADHRVALTGTPVENRLEDLRAVIDLVNPGLLGSASVFRARYAEPIERDRDPAALRRLSAITRPFILRREKSDPAIAADLPEKADFAVRANLTVEQAALYRAVIDELMAALRDKQQRTLRRRNVLAALTRLKQVCNHPAHYLADGTDLVRDGEHRSGKVELLADIVSTVADEGDRALVFTQFAAFGDMLSSWLSAEFGTEIPLLHGGLGRTERDRMVADFQADDGPPVLLATLKAGGTGLNLTAANNVIHVDRWWNPAVEDQATDRAYRIGQDQKVSVHRFVCVGTIEERIDDMIAKKRELSRLTVAAGENWVSDLADDELFELFRLRDEAVSE
>NZ_CP016594|3761556:3770607|3765384_3766389_-|WP_004019252.1|DBSCAN-SWA
MTSTASHSPADGAPIKLVSRVSAINWNRVPDEKDAEVWDRLTGNFWLPEKVPVSNDIPSWGTLTEYEKQLTMRVFTGLTLLDTIQGTVGAVSLIPDATTPHEEAVLTNIAFMESVHAKSYSSIFSTLCSTKEIDEAFRWSEENEQLQRKAQIVMDYYRGDDPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTADLIRLIIRDEAVHGYYIGYKYQRALEVETPERRQELKDYTFELLFELYDNESDYTEALYDEVGLSEDVKKFLRYNANKALMNLGYEAMFPRDETDVNPAILSALSPNADENHDFFSGSGSSYVIGKAVNTEDEDWDF
>NZ_CP016594|3761556:3770607|3769419_3769653_-|WP_004019249.1|DBSCAN-SWA
MSITVYTKPACVQCNATYKALDKQGLSYEIVDISEDAEARDYVMALGYLQAPVVVAGDAHWSGFRPDRIKALATAAA
>NZ_CP016594|3761556:3770607|3770049_3770607_-|WP_004019248.1|DBSCAN-SWA
MSERVVELVALVGSLRAASLNRQLAHVAADNAPSGVSITVVDDLGSLPFYSEDVDIEDQLDAGVAKLRQVVGAADGVLIATPEYNGTIPAALKNAIDWLSRPYGTGALTGKPVAVLSAALGQYGGAWTREDTRKSVGIAGGRAIEEADLGLQVAALPEGGLTDPAIVDKVVASVSRLVDEVAVSA
>NZ_CP016594|3761556:3770607|3764555_3765365_+|WP_004019253.1|DBSCAN-SWA
MTVRKKGTQRRGERGTIAVRGYGLTSWSRGFVDVVEGRGADGESVADSRRITKARRYFRDRHVRGLRIGAGQVTASVEGTQLEPFDVILSTRTVDTATLATLLRERGAVDELMLLTRGEQPPTLGELLVPTESADVETDCTCPDEAPRCIHALVTCYEVAAEIDRTPLTLLTVMGTDLRALLAEIDSRPADTRTSDEAGAPDSLRPDDFYGTTSTLPPLPSPSRMNPLTALDGAELRAALRATGVAPADIAETIDELGDLYDRLTAGDS
>NZ_CP016594|3761556:3770607|3766464_3768657_-|WP_004019251.1|DBSCAN-SWA
MSPTAAVSDTTSASKSGVHPGPAGHDPGELDFHALNAMLNLYDADGKIQFDKDREAANQYFLQHVNQNTVFFHDRDEKLDYLIEENYYEPEVLAKYDRAFVNELFDHAYGKKFRFPTFLGAFKYYTSYTLKTFDGKRYLERFEDRVCMVALTLADGDTTLARNLVDEIISGRFQPATPTFLNSGKKQRGEPVSCFLLRIEDNMESIGRSINSALQLSKRGGGVALLLSNIREHGAPIKKIENQSSGVIPIMKLLEDSFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLGVVIPDITFELAKANDDMYLFSPYDVERVYGVPFADINVTDKYHEMVEDRRIRKTKIKAREFFQTLAELQFESGYPYIMFEDTVNRANPIDGKITHSNLCSEILQVSTPSTFNDDLSYAEVGKDISCNLGSLNIAKTMDSPDIGQTIETAIRGLTAVSDQTSITSVPSIEFGNNNSHAIGLGQMNLHGYLARERVFYGSDEGIDFTNIYFYTVLFHALRASNRIAKERGRAFTGFEKSKYASGEFFDKYLNKVWEPETQKVRDLFGQAGIAIPTQDDWRELKEAVQRDGIYNQNLQAVPPTGSISYINHSTSSIHPVAAKIEIRKEGKIGRVYYPAPYMTNDNLEYYQDAYEIGYEKIIDTYAAATQHVDQGLSLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQIALEGTEVEGCVSCML

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004019254.1|3761556_3764559_+	DEAD/DEAH box helicase	A0A0K0N6W5	Gordonia_phage	1.1e-36	28.1
WP_004019253.1|3764555_3765365_+	hypothetical protein	NA	NA	NA	NA
WP_004019252.1|3765384_3766389_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A160DHK0	Gordonia_phage	6.3e-154	85.6
WP_004019251.1|3766464_3768657_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	2.6e-208	51.3
WP_004019250.1|3768751_3769219_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	Q4Z9B0	Staphylococcus_phage	6.2e-11	31.1
WP_004019249.1|3769419_3769653_-	redoxin NrdH	V5UN81	Mycobacterium_phage	1.3e-22	66.2
WP_004019248.1|3770049_3770607_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	5.3e-09	30.9