CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP016793	Lentzea guizhouensis strain DHS C013 chromosome, complete genome	14 crisprs	casR,csa3,DEDDh,DinG,cas14j,RT,cas3,cas4,WYL,cas6e	0	6	2	0

1. NZ_CP016793

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP016793_1

• CRISPR_ID: NZ_CP016793_1
• CRISPR_location: 213939-214052
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP016793_1

Consensus_repeat	Method
AGCAGCTGCAGCAGTTCCAGCAGC	CRISPRCasFinder

spacers of NZ_CP016793_1

>1.1|213963|18|NZ_CP016793|CRISPRCasFinder
GGCTGCGGGGGGTCGAGC
>1.2|214005|24|NZ_CP016793|CRISPRCasFinder
AGTTCCAGCAGCAGCTGCAGCAGT

CRISPR arrays and Neighbor proteins around NZ_CP016793_1

CRISPR arrays

The CRISPR arrays of NZ_CP016793_1

>merge|NZ_CP016793|1|213939-214052|CRISPRCasFinder
AGCAGCTGCAGCAGTTCCAGCAGCGGCTGCGGGGGGTCGAGCAGCTCCGGCAGCAGTTGCTCCAGCAGTTCCAGCAGCAGCTGCAGCAGTTCGAGCAGCTGCGGTTCCAGCAGC

>NZ_CP016793|1|1|213939-214052|CRISPRCasFinder
AGCAGCTGCAGCAGTTCCAGCAGC	GGCTGCGGGGGGTCGAGC
AGCTCCGGCAGCAGTTGCTCCAGC	AGTTCCAGCAGCAGCTGCAGCAGT
TCGAGCAGCTGCGGTTCCAGCAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_065913285.1|211641_212064_+|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl|CDD|376583
NZ_CP016793.1|WP_065913283.1|210247_211201_+|asparaginase	unknown	unknown	gnl|CDD|377601
NZ_CP016793.1|WP_065913290.1|219289_219982_-|chlorite-dismutase-family-protein	unknown	unknown	gnl|CDD|377705
NZ_CP016793.1|WP_154696978.1|214864_215683_+|DUF692-family-protein	unknown	unknown	gnl|CDD|377459
NZ_CP016793.1|WP_065913291.1|221431_222466_-|uroporphyrinogen-decarboxylase	unknown	unknown	gnl|CDD|234644
NZ_CP016793.1|WP_065913294.1|225506_226766_+|ribonuclease-D	unknown	unknown	gnl|CDD|223426
NZ_CP016793.1|WP_015099292.1|224719_225436_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP016793.1|WP_154696977.1|212330_213200_+|TIGR04222-domain-containing-membrane-protein	unknown	unknown	gnl|CDD|275063
NZ_CP016793.1|WP_065913289.1|216225_219303_+|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|173800
NZ_CP016793.1|WP_065913293.1|223318_224464_-|dipeptidase	unknown	unknown	gnl|CDD|366534
NZ_CP016793.1|WP_065913280.1|206730_207111_+|SsgA-family-sporulation/cell-division-regulator	unknown	unknown	gnl|CDD|377399
NZ_CP016793.1|WP_065913277.1|203788_204349_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|197715
NZ_CP016793.1|WP_065913281.1|207123_209454_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_CP016793.1|WP_065913282.1|209494_210142_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224715
NZ_CP016793.1|WP_065920732.1|215696_216047_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065913284.1|211265_211556_+|hypothetical-protein	unknown	unknown	gnl|CDD|372642
NZ_CP016793.1|WP_071812506.1|214067_214865_+|TIGR04222-domain-containing-membrane-protein	unknown	unknown	gnl|CDD|275063
NZ_CP016793.1|WP_083267719.1|222475_223084_+|DUF3000-domain-containing-protein	unknown	unknown	gnl|CDD|378665
NZ_CP016793.1|WP_083268687.1|204352_204655_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|197715
NZ_CP016793.1|WP_065913279.1|205322_206444_-|ATP-binding-protein	unknown	unknown	gnl|CDD|379062

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065913285.1|211641_212064_+|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl|CDD|376583	pfam01641, SelR, SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.	7.73301e-76
NZ_CP016793.1|WP_065913283.1|210247_211201_+|asparaginase	gnl|CDD|377601	pfam06089, Asparaginase_II, L-asparaginase II. This family consists of several bacterial L-asparaginase II proteins. L-asparaginase (EC:3.5.1.1) catalyzes the hydrolysis of L-asparagine to L-aspartate and ammonium. Rhizobium etli possesses two asparaginases: asparaginase I, which is thermostable and constitutive, and asparaginase II, which is thermolabile, induced by asparagine and repressed by the carbon source.	2.32355e-144
NZ_CP016793.1|WP_065913290.1|219289_219982_-|chlorite-dismutase-family-protein	gnl|CDD|377705	pfam06778, Chlor_dismutase, Chlorite dismutase. This family contains chlorite dismutase enzymes of bacterial and archaeal origin. This enzyme catalyzes the disproportionation of chlorite into chloride and oxygen. Note that many family members are hypothetical proteins.	5.93968e-101
NZ_CP016793.1|WP_154696978.1|214864_215683_+|DUF692-family-protein	gnl|CDD|377459	pfam05114, DUF692, Protein of unknown function (DUF692). This family consists of several uncharacterized bacterial proteins.	3.07821e-111
NZ_CP016793.1|WP_065913294.1|225506_226766_+|ribonuclease-D	gnl|CDD|223426	COG0349, Rnd, Ribonuclease D [Translation, ribosomal structure and biogenesis].	8.0914e-86
NZ_CP016793.1|WP_015099292.1|224719_225436_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.13664e-56
NZ_CP016793.1|WP_154696977.1|212330_213200_+|TIGR04222-domain-containing-membrane-protein	gnl|CDD|275063	TIGR04222, integral_membrane_protein, TIGR04222 domain. The majority of the proteins with a domain as described by this model have an extreme C-terminal sequence that is consists of extremely low-complexity sequence, rich in Ser or in Gly interspersed with Cys. That C-terminal region resembles ribosomal natural product precursors, although there is no evidence that C-terminal regions of these proteins undergo any modification or have any such function.	1.25715e-29
NZ_CP016793.1|WP_065913291.1|221431_222466_-|uroporphyrinogen-decarboxylase	gnl|CDD|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	0
NZ_CP016793.1|WP_065913293.1|223318_224464_-|dipeptidase	gnl|CDD|366534	pfam01244, Peptidase_M19, Membrane dipeptidase (Peptidase family M19).	2.57335e-131
NZ_CP016793.1|WP_065913280.1|206730_207111_+|SsgA-family-sporulation/cell-division-regulator	gnl|CDD|377399	pfam04686, SsgA, Streptomyces sporulation and cell division protein, SsgA. The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division.	1.08306e-28
NZ_CP016793.1|WP_065913277.1|203788_204349_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	9.15599e-14
NZ_CP016793.1|WP_065913281.1|207123_209454_-|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	7.63606e-10
NZ_CP016793.1|WP_065913282.1|209494_210142_-|GntR-family-transcriptional-regulator	gnl|CDD|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.01973e-46
NZ_CP016793.1|WP_065913289.1|216225_219303_+|S8-family-serine-peptidase	gnl|CDD|173800	cd07474, Peptidases_S8_subtilisin_Vpr-like, Peptidase S8 family domain in Vpr-like proteins. The maturation of the peptide antibiotic (lantibiotic) subtilin in Bacillus subtilis ATCC 6633 includes posttranslational modifications of the propeptide and proteolytic cleavage of the leader peptide. Vpr was identified as one of the proteases, along with WprA, that are capable of processing subtilin. Asp, Ser, His triadPeptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	1.08049e-72
NZ_CP016793.1|WP_065913284.1|211265_211556_+|hypothetical-protein	gnl|CDD|372642	pfam13593, SBF_like, SBF-like CPA transporter family (DUF4137). These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, pfam01758.	0.00951713
NZ_CP016793.1|WP_071812506.1|214067_214865_+|TIGR04222-domain-containing-membrane-protein	gnl|CDD|275063	TIGR04222, integral_membrane_protein, TIGR04222 domain. The majority of the proteins with a domain as described by this model have an extreme C-terminal sequence that is consists of extremely low-complexity sequence, rich in Ser or in Gly interspersed with Cys. That C-terminal region resembles ribosomal natural product precursors, although there is no evidence that C-terminal regions of these proteins undergo any modification or have any such function.	8.80889e-12
NZ_CP016793.1|WP_083267719.1|222475_223084_+|DUF3000-domain-containing-protein	gnl|CDD|378665	pfam11452, DUF3000, Protein of unknown function (DUF3000). This is a bacterial family of uncharacterized proteins.	1.60866e-89
NZ_CP016793.1|WP_083268687.1|204352_204655_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	3.81086e-11
NZ_CP016793.1|WP_065913279.1|205322_206444_-|ATP-binding-protein	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	0.00011397

Protein sequences

>NZ_CP016793.1|WP_154696977.1|212330_213200_+|TIGR04222-domain-containing-membrane-protein
MEPWGLSGPEFLQLYWIGLALAVLAAIVIRVRARAGGSQPVRTLDVDEIAYLAGGPRRVVETAVARLLTAGELRISRRGAVSATNSPQSRNHVDRAVLTDSQRYSNRTVSLMIPAVAKDIAVRAIGLRLQELGLVLSEEAVKRARRNGSALLWLLLAVGVVRWVNGIAIDANIGWLSVQLVITAVLIFFVLRRGKNLRTTTGDRVLDAARTAGGRATGSEDPALVGAAGLVALGGLTVYPDLAVRSSLLAAPAGTSSGYTGGSACSTSSSSCSSGSSCGGGGGCGGGGS
>NZ_CP016793.1|WP_065913285.1|211641_212064_+|peptide-methionine-(R)-S-oxide-reductase-MsrB
MEPVVGTTPKVVRSEEEWRTQLNPAEFAVLRQAGTERPWTGEYVETKTEGVYECRACGAELFRSDTKFDSHCGWPSFFSPLAGEAVILREDRTLGMKRVEVLCATCHSHLGHVFEGEGYPTPTDQRYCINSVSLKLVPSE
>NZ_CP016793.1|WP_065913284.1|211265_211556_+|hypothetical-protein
MGDPKDEREQFQEELIGLDPHDPETKAFAEHLDRMKRERSGYTVEGYLDGVQDFADSANRTTGHRRLVAVLVVGLILLGVVLTIWFALSDIVTIIF
>NZ_CP016793.1|WP_065913283.1|210247_211201_+|asparaginase
MGHEVVAEVWRGDFLESVHHGTVVATDATGTPVLSVGRPDDVAFPRSSNKPLQALAMLRNGLDLDGELLALACASHSGEDFHVEGALRILAGAGLTEDALRCTPDLPIGEAARAQHLARGLGAAPKYMNCSGKHAAMLATCVANGWSTEDYLDPAHPLQVATRATIEDVAGEPVAQVGVDGCGAPIFAISLTGLARAFGRLASAPEGTLEHRVAAAMNAHPQWVGGTGRDVTVLMDALPGVIAKDGAEGVYAVGLPTGEGVALKIADGSSRARAVVVVAVLKRLGVDVDGVAGLATVPVLGHGRAVGAVKPSLAVAS
>NZ_CP016793.1|WP_065913282.1|209494_210142_-|GntR-family-transcriptional-regulator
MTPPLHLSLAGQAVDVLREQVLTGVIPAGARVNEVEVAQQLGISRGPLREAIRHLASEGLLTLVPHRGAFVPAADEDEVRALFELRTALECAAAELAASRRTDVDLVRLQEVCAESRRNYRAGQPFPYRLDLAFHQTLLDAARSPRIAEQVRLVQQRVVLLRSALEDDPPHQHASMDDHDELVRAIADGDAARASGVMRRHLSRVCAQMLTSLNA
>NZ_CP016793.1|WP_065913281.1|207123_209454_-|helix-turn-helix-domain-containing-protein
MRGTTFGEFLRFYRRRAGLTQEQLASRTGLSVRALSDLERGRVHTPQASTIDLLVAGLELDLGEAGEFGTLARLGEAVQPRPERADRTCSPPPAVELAGRAAEQRQLAEWVMSASTSNLLDVVVVHGPPGVGKTALAVDAAHRFGCAFADGCLYLDLRGMDPAPLSPDRAIARLLTAFGVPDARMPSDAGDRDRLYRSMLRERSVLLVLDNAANEAQLRPLLAAAPGSLVLVTSRNILAGLIARHRVELGPLSSDGAVALLTAVAGDRVRADRESAGLVAGLCGGIPLALAIAGHRLTGPWSPRQLADRLSDERERLDVLATDDVQVRTAFELSYRLLAPGTATVFRRLALVPGPDTSAELAAVAAKISPEDAEALLEELVDASLVRPGDLPGRYTFHDLIRDYARERLHSEEPDLDTHRLRTRDWLMARATTAAALFHPDEQGAADLENADRWLLVERANWRGALREAVRDGDHEVVLELANAMHWYSDHRGPGELWAEVYTAGVDAAHALGRTEHEAKQLNFLTWVYFARAARLPLALQTHEAALRLAEECGSTVETAWAHYYRAGVETRLGNHATAVTHGRRAAELFRVAGLPMGVVFALSFTGVLLQRMGRSADAVETHRAAIAEEREVRDTQRGVARENTAQLLLRLADSLTAAGEPEQALPVVAEAETLVGEFGGLRAMVRHSRARALVAADRFAEAREQLAGAAETMVDPEARVSVLIELARTCEQMGDHDASTRHRVRALAESEGYESPGMTKLQHEVAEALGIRLTG
>NZ_CP016793.1|WP_065913280.1|206730_207111_+|SsgA-family-sporulation/cell-division-regulator
MRVASRTVFDFIRPDGAGAPVDTEMVYSADDPFAVTMHFHAGGAVSTWIMGRDLLWDGLSRPAGKGDVRVRPSGRAVVLELVSDRHVTVFRVPASTLRKFLDASHRLVSPGTEHFDADAFLSTVLR
>NZ_CP016793.1|WP_065913279.1|205322_206444_-|ATP-binding-protein
MSAPSPRRLGPAGAATSQAAGRLVGREREVAAVTEALRDGRSCVVHGGPGTGKSALLAVASSIAVRSGMTPVRAWSGVDRRTVLVVDDAEQLPAEKVERLARYRGPVLLAGDVDPDVVLDLLPGAAAVAVRPVGAAAVTELLRRRVDGEVPPELTELCLRFTGGAPGVLSDVLDLVPDLAVRCLRETLPALRLPRLLRAVRRWAVLDAAAVTVGRALAVLGEVEPAVLGEVTGMSSVEVLAAVERLVDARLAFAGPTRIQSPALGHAIRHEMTPHARERLHRTAAHVLYRRRDTATAVAEQVVACAEPVALPWVAPVLVAAARLHRVAGRPEQAVRCLRAALREPMDARGAEEVAAGMADLHLRCGIAPRAGS
>NZ_CP016793.1|WP_083268687.1|204352_204655_-|helix-turn-helix-transcriptional-regulator
MALWRADNLAIAPWRLVAGAAKARLGGTAVREPARRTGSAWGRLTPHESRIVRLALDGETNRAIATRFNVTQRAVELHLTRVYRKVGISRRVQLSAVFGD
>NZ_CP016793.1|WP_065913277.1|203788_204349_+|helix-turn-helix-transcriptional-regulator
MSSAIALVDAGIEPVRVAVDSRDLISAAGVTHLLKNSPRVRVVTDRADAHVLLAVVNELCAQQAARLKAIAAPRIVVIAARVHDLTPSIAAQAGLANPVRRADVNTERLEKLLLGGQTLQEAPSVLSDRDLRLLRLLAEGATIAEVAQRLFCSERTVKYALHQLLDRFGLRNRVHAVAWAIRAGLL
>NZ_CP016793.1|WP_071812506.1|214067_214865_+|TIGR04222-domain-containing-membrane-protein
MTTTTWQNTRLSVEEIGYLTAGPGRAAETALARLIDAGLVRVSREGLVSAVHQDGQGAATSVERQILAQLRTAVRFELVVQSAAYSSEVQWLHRQLHLRKLMQLPRRRGESWWAYPVIAVVLVLLGVVYWPVFLVGVPVAVLLFFWTRGRGPLTKAGLQVLLQTTAHDRVHAVALHGFCGRLDGRPVADLFGLPQKVVKMLPRKPNRRQSSSDGGGHGAAAGCGSCGSGCGSNSCASSSGGSSCSSSSGSSCSSGGGCGGGGGGD
>NZ_CP016793.1|WP_154696978.1|214864_215683_+|DUF692-family-protein
MAGIKDLGVGIGWRSEIDLTVERLPGVDFVEIVAENIHTGHLPESVTILLERGIPVLPHAVSLSLGGAEEVDLKRVDHLASVAEAVGAPMVSDHVCFVRAGGLDSGHLMPVPRTRDALDVLVANVKRAQEHLPVPLALENVAALLEWPDGELTEGQFLAELVERTDCWLLVDVANLYANARNIGTDPQRFLDEIPLERLAYVHVAGGEQHGDIYHDTHAHAVLPEVLDVLDELCSRVAPPGVLLERDDNYPSDAEISAELAAIRAVVDKHRG
>NZ_CP016793.1|WP_065920732.1|215696_216047_+|hypothetical-protein
MDHSSARERLAARQAELLNALLAGGPAPAGFDEQRVEVERRALLAKRRGIVRMLGPEVANELGDRFRQLFDAYALANPRRASSRAREDAAAFADWLRAAGELQVKRKARWKFWQSN
>NZ_CP016793.1|WP_065913289.1|216225_219303_+|S8-family-serine-peptidase
MRGKSKVLGAAFAALALTAVPATGASAAPVPGQPIKAVDEVTLVTGDKVLLGPGQQVVAVQPGEGRQQMTFKTHRGADGHVTVVPKDAFEPLAADRLDRRLFDVTTLLEFGYRDRMPLLVNGHARAGARTAGDWSALRQTGDKIWLDGLRKPALDRSVAQIGAPAAHQRGITGKGIKVAIVDTGVDENHPDLKGQQVAERNFTTDPDNTDNVGHGTHVGSTVASHDAKFGGVAPGVQLLDAKVCIEFGCQESWILDGMRWAAEQGAQVINMSLGGGDTPEVDPLEQAVNDLTAQYGTLFVISAGNSGSPGTVGSPSTAEAALSVGAVDRADKLAPFSSRGPRVGDSGLKPEVTAPGVGIVAAAAGTNGEHVAADGTSMAAPHVAGAAALLRQQHPEWTPAQVKSALATTAKPTAGVSAFDQGAGRIDVAKAVDQVLTADVVALNLGRHEWPHADDKPETKPVTYTNPTDAPITLDVRIDTSAPAGMFTLSASRVTVPAKGTASLQVTADTRVGGKDGLYSGEVVATSGTHTVRTLVGVDREVESYTLTIDLTDRSGADPASSLTFVDGLDVTAFKAVIGAGDQKLRLPRGTYMLDSSISTPEGLDLLLQPTVKLTGDLTVKQDARLAQKIDVRAPEPTGTFAVGELAWQRTFGERRIGAGLISFGGFDRISAAQVGGPLSPRELASLTVLHANSAAEANTYYRLAYPVGGSLPNGLTRAPEKKDLARVETSFGVKPDSLVAKGELPLSVHGIGGGTALYEVPAGAKAVDFVTTEDLRWQSMVSLQHANGAQERITSNLRTYAPGRTFPEREVVPVFSPGLPESPYPFAERYRDQLFIGVPMLADGNHGSGASTVDKARTALYRDGTLVGELPQTGGSFAGLPLGEASYRAEVSLDRATQFDLSTQVSGKWTFKSKATGDRPTPVPLSVVRFAPKLDANGSVPAGTLQRIGLLTQSQGDTGKVRVTGVEYSFDDGKSWRRAGVVGNSALVYHTADAKFASLRATALDAKGGTVELTVIRAYRVTAG
>NZ_CP016793.1|WP_065913290.1|219289_219982_-|chlorite-dismutase-family-protein
MARLNYNELNDTIRYTMWSVFRVEPGKLPEDRSAAASETQNYLDALEGKGVVVRGVYDVAGLRADADYMIWWHAEEIEQVQAAYTGFRRTPLGKVSTPVWSQVALHRPAEFNRSHIPAFLAGEEARKYICVYPFVRSYEWYLLPEEDRRKMLADHGKEARDFPDVRANTVASFALGDYEWLLAFEADELHRIVDLMRHLRGTEARLHVREEIPFYTGTRVPAAELVTNLP
>NZ_CP016793.1|WP_065913291.1|221431_222466_-|uroporphyrinogen-decarboxylase
MTPQVPLLVAASGGTPSHTPVWFMRQAGRSLPEYRALRQGTAMLDACMDPEMVCEITMQPVRRHGVDGAILFSDIVVPLKAAGVDLDIVAGTGPVVAHPVRTLDDVEALPRLHAEQVQPVADAIGLLLKELPQEVALIGFAGAPFTLASYLVEGGPSKNHERTKALMHGNPELWHALLAKIADVTAAFLHAQLDAGVQAVQLFDSWAGALSERDYREFVLPHSKRVLETISGVPRIHFGVGTGELLPAMREAGADVVGVDWRIPLDVAVQRLEQANPELPKPVVQGNLDPALFFAGFEAVEREVRRIHAEGKAARGHIFNLGHGVLPDTDPEVITRTVELIHSL
>NZ_CP016793.1|WP_083267719.1|222475_223084_+|DUF3000-domain-containing-protein
MVPRLGVPPSLGRFARHTVSCVTEPEIFRRAVGTLKSVRHRPEIELTEVRPPQRLAPWAYALTAEVTGPSDELSTGRLVLLHDPDGDEAWGGVLRVVAYVRVELDHELASDPLLPEVGWSWLTEALEQSAARFTALGGTVTQTSSARFGDIAGPARTDDLELRASWTALDGELAEHGTAFYELMATAVGLPPVGVTMFGQRS
>NZ_CP016793.1|WP_065913293.1|223318_224464_-|dipeptidase
MQSSSGVERARALLQRVPLVDGHNDLPWALREFGEGTGEDVYTTAAKVDLTERHPDLHTDIVKMREGGLGMQFWSVWIPGRLAGDGAVTAVLEQVELVYELAQRYSEHLGIATTAAEAEKVFASGRVASLLGAEGGHSINSSLGVLRALRRLGVRYMTLTHNDNTPWADSATDQPEHGGLTEFGREVVREMNRIGMLVDLSHVAPATMHAALDTSVKPVIFSHSSCRHIADHPRNIPDDVLVKLKANGGVAMITFVPDFVSPRVAEWDAALRDAMTAAGASHADMAERKTFSEQWVEEHPKPDAALDDVVTHLEHAREVVGVDHIGLGGDYDGVKALPQGLEDVSTYPNLIGALLDKGWSEDDVTKLAGGNILRVLHDADS
>NZ_CP016793.1|WP_015099292.1|224719_225436_+|response-regulator-transcription-factor
MAAVGLGQAVRTTPAGSLPANMVPHPREELFSVLVVDDHPLLREAISARLTQMGAGTVHEAASVAEARARALATGPCDLAILDLGLPDGTGIDLVTELRAQGWPRIVVLASSDDPYAVRSAFQAGAQAYLLKSASPMVVTDGVRRVLDGGVYADPSVAPVLAAGTRVPGTDNTPRELSAREVEVLQLVADGQSNKEIGEALSLSALTVKSHLSRIGRKLGTGDRAQMVALAMRAGVIR
>NZ_CP016793.1|WP_065913294.1|225506_226766_+|ribonuclease-D
MDVPADEPTAPAGPGPVPLTEPADGVPPVVADPSALRRAADALAGAKGPVAVDTERASGYRYSQRAYLVQLRREGAGTWLVDPIALGGRLDPLVEALEGTEWVLHAASQDLPCLAELGLRPGVLFDTELAGRLAGFERVALGTLVERLLGYRLEKGHGAADWSRRPLPADWLTYAALDVELLVQLRDVLEAELERQGKLAWALEEFEAVRTAPLPRPRTDPWRRTSGIHRVRNQRQLASVRALWEARDAVARERDIAPGRVLPDSALMEAAARNPATEAELLALPVFRGRAQRRMSGTWMNALRRASALSKSELPEPAAQHDGPPPPNRWADKDPDAAARLGATRTALAAIAEANTLPVENLLLPDLVRRTCWQPPADLSPESVAAVLREGGARSWQIDLTAEALAKALTATAPPPASS

Crispr_ID: NZ_CP016793_2

• CRISPR_ID: NZ_CP016793_2
• CRISPR_location: 520654-520752
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016793_2

Consensus_repeat	Method
GTGACAGCGTCTAACGAACGCGAGA	CRISPRCasFinder

spacers of NZ_CP016793_2

>2.1|520679|49|NZ_CP016793|CRISPRCasFinder
GCGTCTAACGAACGCGAGAGCTGCGAAACAGCTGAAGCCCAGCACGAAC

CRISPR arrays and Neighbor proteins around NZ_CP016793_2

CRISPR arrays

The CRISPR arrays of NZ_CP016793_2

>merge|NZ_CP016793|2|520654-520752|CRISPRCasFinder
GTGACAGTCTCTAGCGAATGTGACAGCGTCTAACGAACGCGAGAGCTGCGAAACAGCTGAAGCCCAGCACGAACGTGACAGGGTCTAACGAACGCGAGA

>NZ_CP016793|2|2|520654-520752|CRISPRCasFinder
GTGACAGTCTCTAGCGAATGTGACA	GCGTCTAACGAACGCGAGAGCTGCGAAACAGCTGAAGCCCAGCACGAAC
GTGACAGGGTCTAACGAACGCGAGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_065913519.1|513662_513914_-|acyl-carrier-protein	unknown	unknown	gnl|CDD|376348
NZ_CP016793.1|WP_065913526.1|522555_523161_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP016793.1|WP_065913529.1|525197_525521_-|(2Fe-2S)-binding-protein	unknown	unknown	gnl|CDD|223706
NZ_CP016793.1|WP_065913520.1|514072_514882_-|AfsR/SARP-family-transcriptional-regulator	unknown	unknown	gnl|CDD|276938
NZ_CP016793.1|WP_065913532.1|529048_529807_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|212491
NZ_CP016793.1|WP_065913515.1|510511_511780_-|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	unknown	unknown	gnl|CDD|238430
NZ_CP016793.1|WP_170067860.1|518335_520573_+|histidine-kinase	unknown	unknown	gnl|CDD|226951
NZ_CP016793.1|WP_065913518.1|512698_513634_-|aromatase/cyclase	unknown	unknown	gnl|CDD|176870
NZ_CP016793.1|WP_154697003.1|515092_515284_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065913525.1|521859_522447_-|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl|CDD|179647
NZ_CP016793.1|WP_065913516.1|511776_512502_-|hypothetical-protein	unknown	unknown	gnl|CDD|163679
NZ_CP016793.1|WP_065913524.1|520846_521854_-|ketoacyl-ACP-synthase-III-family-protein	unknown	unknown	gnl|CDD|238423
NZ_CP016793.1|WP_065913514.1|509300_510515_-|ketosynthase-chain-length-factor	unknown	unknown	gnl|CDD|238428
NZ_CP016793.1|WP_065913531.1|527787_529020_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NZ_CP016793.1|WP_065913528.1|524404_525184_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187649
NZ_CP016793.1|WP_065913522.1|517537_518209_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065913527.1|523182_524403_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|170080
NZ_CP016793.1|WP_065913517.1|512503_512689_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065913530.1|526317_527730_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|312032
NZ_CP016793.1|WP_065913533.1|529906_530230_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065913519.1|513662_513914_-|acyl-carrier-protein	gnl|CDD|376348	pfam00550, PP-binding, Phosphopantetheine attachment site. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of the anguibactin system regulator AngR has the attachment serine replaced by an alanine.	3.96155e-05
NZ_CP016793.1|WP_065913526.1|522555_523161_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.80528e-58
NZ_CP016793.1|WP_065913529.1|525197_525521_-|(2Fe-2S)-binding-protein	gnl|CDD|223706	COG0633, Fdx, Ferredoxin [Energy production and conversion].	1.37595e-18
NZ_CP016793.1|WP_065913520.1|514072_514882_-|AfsR/SARP-family-transcriptional-regulator	gnl|CDD|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	3.80845e-51
NZ_CP016793.1|WP_065913532.1|529048_529807_-|SDR-family-oxidoreductase	gnl|CDD|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	7.29957e-64
NZ_CP016793.1|WP_065913515.1|510511_511780_-|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	gnl|CDD|238430	cd00834, KAS_I_II, Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.	1.63005e-176
NZ_CP016793.1|WP_170067860.1|518335_520573_+|histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	9.31502e-34
NZ_CP016793.1|WP_065913518.1|512698_513634_-|aromatase/cyclase	gnl|CDD|176870	cd08861, OtcD1_ARO-CYC_like, N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains. This family includes the N- and C- terminal aromatase/cyclase (ARO/CYC) domains of Streptomyces rimosus OtcD1 and related domains. It belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. ARO/CYC domains participate in the diversification of aromatic polyketides by promoting polyketide cyclization. They occur in two architectural forms, didomain and monodomain. Didomain aromatase/cyclases (ARO/CYCs), contain two ARO/CYC domains, and are associated with C7-C12 first ring cyclized polyketides. Streptomyces rimosus OtcD1 is a didomain ARO/CYC. The polyketide Oxytetracycline (OTC) is a broad spectrum antibiotic made by Streptomyces rimosus. The gene encoding OtcD1 is part of oxytetracycline (OTC) gene cluster. Disruption of this gene results in the production of novel polyketides having shorter chain lengths (by up to 10 carbons) than OTC. Monodomain ARO/CYCs have a single ARO/CYC domain, and are often associated with C9-C14 first ring cyclizations, these latter domains belong to a different subfamily in the SRPBCC superfamily.	5.429e-40
NZ_CP016793.1|WP_065913525.1|521859_522447_-|NAD(P)H-dependent-oxidoreductase	gnl|CDD|179647	PRK03767, PRK03767, NAD(P)H:quinone oxidoreductase; Provisional.	2.13264e-43
NZ_CP016793.1|WP_065913516.1|511776_512502_-|hypothetical-protein	gnl|CDD|163679	cd07941, DRE_TIM_LeuA3, Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain. Desulfobacterium autotrophicum LeuA3 is sequence-similar to alpha-isopropylmalate synthase (LeuA) but its exact function is unknown. Members of this family have an N-terminal TIM barrel domain that belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	2.28243e-35
NZ_CP016793.1|WP_065913524.1|520846_521854_-|ketoacyl-ACP-synthase-III-family-protein	gnl|CDD|238423	cd00827, init_cond_enzymes, "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the utlization of CoA substrate primers, as well as the nature of their active site residues.	5.57061e-52
NZ_CP016793.1|WP_065913514.1|509300_510515_-|ketosynthase-chain-length-factor	gnl|CDD|238428	cd00832, CLF, Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein (ACP). CLFs are similar to other elongation ketosynthase domains, but their active site cysteine is replaced by a conserved glutamine.	0
NZ_CP016793.1|WP_065913528.1|524404_525184_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187649	cd08945, PKR_SDR_c, Polyketide ketoreductase, classical (c) SDR. Polyketide ketoreductase (KR) is a classical SDR with a characteristic NAD-binding pattern and active site tetrad. Aromatic polyketides include various aromatic compounds of pharmaceutical interest. Polyketide KR, part of the type II polyketide synthase (PKS) complex, is comprised of stand-alone domains that resemble the domains found in fatty acid synthase and multidomain type I PKS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	3.00642e-140
NZ_CP016793.1|WP_065913531.1|527787_529020_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.0235e-83
NZ_CP016793.1|WP_065913527.1|523182_524403_-|FAD-dependent-oxidoreductase	gnl|CDD|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	2.49541e-75
NZ_CP016793.1|WP_065913530.1|526317_527730_+|alpha/beta-fold-hydrolase	gnl|CDD|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	7.78106e-09

Protein sequences

>NZ_CP016793.1|WP_170067860.1|518335_520573_+|histidine-kinase
MSRRLAYFVISVVFANYLLDNFLDVIKIGATPGRIAGSLACLLAIGYLQLRVFSRPGANLRSGRAYLALGAMAVLVYAPLAFFPDELNNMPGFLAGSSLLVLPGRVRWLVFFAVALGNGGIQAWYADDVSSQIYYMIASMVAGLVVYGLSRLPSLVEQLETVRSELAALAVSQERLRFARDLHDLLGFSLSAITLKVELARKMLGTHTERALRELAEVLGIAREALTDVRAVASSYRELSLADEIESACSVLTAAGVATTIETDHPELSPRSRTVLATVLREGVTNLLRHSEATRCAITISSAGGAVSIDIVNDGAPAEVGTERGSGLTNLATRAMAIGGSLFARTSSDGTYRLHAEVPVEPAPQEPAGDARPAGQPMAARFAQVLFTVVVVGYGLMSLSQVAFDYPRIGLPGMAVAVLATAVEVGLVLSLVGRPRVRLNLASSLLVLAAMAVCVYVPVWMYGNPLMGVAGFLAGAAALLLPRPVGWMAFFAVVVTQLLMMWIGFDPGFFWLAYGLYSVMNHGLVLYALTRLRSMVSELHEAREELATAAVAQERLRFARDLHDLLGYSLSAITLKSELTHRLVTIDQDRARQELTEVLEISRQALADVRSVALSYRELSFDEETQSAQALLAAADIEVTVRIEACDRLPKDVTVTLATVLREGVTNLLRHSKAEHCEISLCRNAELVRMDIVNDGISDSARSSRDGSGIGNLTTRVRALGGELHAGLLPDQKFRLRAEIPLPAN
>NZ_CP016793.1|WP_065913522.1|517537_518209_+|hypothetical-protein
MSTTQSGGAAVTTQSHIPSGRPLWSLLEDAFVDEGGDTLTVHGRWGAIELADTSPLVREALHRMSLGPVALENISALHDNFVRWKTGSGPCLIWRKLKNTLDQLGGCVVPSLGLNDGAGPILSVVAVTGNAVFSLPHLGDDDVVTLRPGTEIERLNGDQALVCSGQPYQVILHSAPATEITKALLDAETTVAQVAEALQVDEELVADVIAYLAGAGLVVTTEN
>NZ_CP016793.1|WP_154697003.1|515092_515284_+|hypothetical-protein
MSATVTVEHLASVTTAIDDSDDMKIYQFDREASMDVIFATWWCSGSGSVIGSSYTAHDEVLAA
>NZ_CP016793.1|WP_065913520.1|514072_514882_-|AfsR/SARP-family-transcriptional-regulator
MQIKVLGPVEAKVNGRSVTPTAAKPRQILALLALHAGQVVSVPTLIEELWGDRPPRSARTTLQTYILQLRRLIGDALSASDASEAKEVLVTRYGGYLLDVPAEAVDVHEFERLARAGQQACDVEDFASASRLLRQALEMWRGPAVVDVRPGMPLSIEVVRLEEARLGVLEARIDAELRMGRHKALLSELSVLTVQNPMNENLCAQYMISLFRAGRQWQALDAFKALRNTLIEELGVEPSSRLQGLQHAILTSDPRLDSAETRQLQRLLA
>NZ_CP016793.1|WP_065913519.1|513662_513914_-|acyl-carrier-protein
MSALTIEGLKEILNEAAGDDDSFKPGQDILDIPFLELGFDSLALLETVALIKRKHGVAIADDEMAYLETPRQLLDKVNGQIAA
>NZ_CP016793.1|WP_065913518.1|512698_513634_-|aromatase/cyclase
MTHTTTHTVMIGAPAKVVYDLVADVTTWPYIFGPTVQAEVFERDGSTERLRLHAFANGDVRTWTSRRVLDPANLHISFEQERSAAPVKTMGGEWRIVPIADSATRVDLLHHFTAAQPEAVDVILNAVNNNSDAELAALKRAAEYGDDYDKLVLSFSDSITIHASRKDVYEFLYRSDLWPQRLPHVARLDLTEAVTGVQSMEMDTRSPDGSIHTTHSVRVCTPYDGIVYKQTHTPPIMAAHVGRWTFRDIGDGVEAGIEATSHHTVVIRPEVVPEVLGADGTIERARELIRHALGTNSLTTLRHAKEFAENG
>NZ_CP016793.1|WP_065913517.1|512503_512689_-|hypothetical-protein
MGLRGADLLTAAARAASRNGLYVVSMYLEKAAVEHQRKGCPSEVGHCAYEIEASRVLLSGF
>NZ_CP016793.1|WP_065913516.1|511776_512502_-|hypothetical-protein
MDLYDISLRRTGLSTSDSLVAARRLDALGVTFVDGGRPGRSSYPRRFYARAAVELRLRVATLIASGGPEDLVALMAAETPAVAVVVQGHGFSVLREAVRQLVRAERRVIVEARDFFDGWLIDPDDALEVVLTAAEAGAETVILHDTAGALWPDQVGEILAVVAETGVPLGFGGGGGDSVAKQLFAADAGAGLVQGSYAVVRGGLDRAVSPSVHPAETGVAPVPCPRLEQTVSAQKAIGGVR
>NZ_CP016793.1|WP_065913515.1|510511_511780_-|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein
MSRRAVITGVGVVAPGGIGTKAYWKLLSEGRTATRNITHFDASPYRSRMAGEADFDPVREGLTPQEIRRLDRAAQFAVVAGREAMSDSGIEFDQLDPGRIGVSLGTAVGCTTSLEREFIVGSDRGKYWEVDQSYAVPHLYDYFTPSSMATELAWTVGAEGPVSVVSTGCTSGLDSVGYAAELIMEGSADVVVTGGTEAPLSPITVVCFDVIRASSTRNDDPATACRPFDKTRDGLVLGEGCAIIVLEELEHARARGAHIYGEVAGFASRCNAYHMTGLHPEGIEMSDAINIALKQARADATDVGYINAHGSGTKQNDLHETAAFKRSLGAHAYKTPVSGFKSMIGHSLGAIGSLEIVGSLLAFEQDLIPPTANLHEPDPECDLDYTPLVAREKKVDTVLTVGSGFGGFQSAMVLKKVEGAGR
>NZ_CP016793.1|WP_065913514.1|509300_510515_-|ketosynthase-chain-length-factor
MTRAVVTGIGIASPNGLGPTAYWRATLHGEAAIKPITRFDSANYWAKIAGEVPGFEAGRHLQGRLLPQTDHMTRLTLVGTDWALRGAGVQPNDIPDTDIAVITAATAGGYEFGQRELQKLWHQGPEYVSAYQSFAWFYAVNTGQISIRHGTRGPGAVVVSEQAGGIDSIGHARRQLRKGVQLALTGGMDSSLCPWAWVAHQASGCLSRNNNPKRAYLPFDRDASGYVAGEGGAIMVVETPESAAGRPGTRIYGEIVGYASTFDSRMPSREPGLKRAAELALRDAGMDASEIDVVFADAAGIPELDKAEAEAIKGIFGPYGVPVTAPKTMTGRLFAGGGSLDVASAILSIYWSAIPPTVNVENVVPEYELDLVLNEARHGKIKAALVLGRGKGGFNSAMVVREYR
>NZ_CP016793.1|WP_065913524.1|520846_521854_-|ketoacyl-ACP-synthase-III-family-protein
MRVKDVFVNGTGVRLPATLTVADAIASGECEPKLVARTDVESVAVSPTESAAEMAVAAAQIALNRAGSAPDDVDLILHATTYHQGQDLWPVGSYIQRETVRNSCLALEIRQMSNGGMAALDLAVSYLVARPGRDALLTTSDRFCLPGIDRWRTDPGTPYGDGASALVLSTRGGYAKLLSLAINADSDLEPLHRGDVPFGLAPFSHRIPVDFEEAKHTFSREFGLSYGINKANAGQARTVEEALSDADMKMGDADWVILPHFGRRRLDVNYLRPYDIEPERTTWEWSRTVGHLGAGDQFASFDHLVQSGKAEPGQRIVMVGVGAGYSWGCAVLEMV
>NZ_CP016793.1|WP_065913525.1|521859_522447_-|NAD(P)H-dependent-oxidoreductase
MERSVNVTVVYYSSTGTIHRLATEMVETAEKHGAEVRLVRAAELAPATAIESRPAWKAHLLDTADVPVAAVDDVLWADAVVFGTPTRFGNVSAQLKQFIDTLGPAWFSGLLANKVYSAFTSGGSVHGGMETTLVSIYNMVCHFGGIIVPPGGDFNPYGTSHVLGADNRPVCDVVLRAAQVQAERVVRVARALKEV
>NZ_CP016793.1|WP_065913526.1|522555_523161_+|response-regulator-transcription-factor
MIRVLLAEDMHMVRGALIALLNLEPDIEVVAEVSSGDKIVPAARQHRPDVCVIDIDLPILDGLTAASTIRETMPQVRTLMLTSLGRPGTLRRALAARVDGFLLKDAPPGELADAIRRVAAGERVVDSQLALAAWDRGECPLTDREVEVLRMAANGADAPDIATALSLSVGTVRNYLTTIMTKLNARNRVDAIRIADDAGWL
>NZ_CP016793.1|WP_065913527.1|523182_524403_-|FAD-dependent-oxidoreductase
MRGESVVVVGAGQAGCQVAVSLREQGHRGPITIVGDEPAKPYQRPPLTKAYLAGETDLAGLSLRQDSYYEDHGIKVLTNERVLGVDRAARVAVLGCARTIGYDHLVFATGARPRPLPIPGAEHVLNLRTAADADEIRKRLHNQVGLDVVVIGGGFIGLEFAAVVRKLRHEVTVVETQPQVMQRAVTKDTAQQLVNRHRSEGVQILTGTGVASVKEGLVELTDGTVLVADLVVAGIGVIPNTEVAQRSGLATDNGIVVDAHLRTVDPRVHAVGDCARFASTITGGLTRVESVQNATDQAICVANAILGSAEPYTALPWFWSDQYDVKLQIAGLTDGHDHAVTVGDPAEGRFSVFCFRGGRLAGVEAYNKPIDFIMARRVLEQGNALTPEIVARPGFDLRSSMQQQAA
>NZ_CP016793.1|WP_065913528.1|524404_525184_-|SDR-family-NAD(P)-dependent-oxidoreductase
MSKRRVALVTGATSGIGLEVARSLGNQGHAVFVVARNAENVQTTVKQLKEEGIDADGAAADVTSTEDIRNAVQKAVDVFGPVEILVNNAGRGGGGITAELDENLWLDVIDTNLNGVFRFTKEVLSTGKMTEQSWGRIINIASTGGKQGVVFAAPYSASKHGVVGFTKAVGIELAKSGITVNAVCPGYVETPMATKVRQGYANHWGVTEDEVLEKFNAKIPLGRYSTPEEVAGLVTYLTTDTASSITAQALNVCGGLGNY
>NZ_CP016793.1|WP_065913529.1|525197_525521_-|(2Fe-2S)-binding-protein
MPKITYVSHDGIETVVDVAQNDTVMRGAVLNGIKGIVAQCGGGASCGTCHVYVDPENTKPLSQMHQVEDELLYFTACERKENSRLSCQLPVTDEQDGLVVHMPEKQL
>NZ_CP016793.1|WP_065913530.1|526317_527730_+|alpha/beta-fold-hydrolase
MPLKEFYDQQVNWSPPFEDGLERATVVVPRDYSDPDGPKLTIALARLRATGERRGVLLAVNGGPGGDGGDGLGLIKHFGARLRSAYDLIGFDPRGYGESTKLYSEVTVPKAPFDSRPPDSLFAQLAEDMRVRELGCQKAGGELRPHITTRNTARDMDLIRVVLGEEKISFVGYAYGTYVGAVYGTMFPEHLDRTVLDSCINPQWTWREQFVTQAEAVYRNVELWARWTAERDGHFHLGTEEKAVIAEIEDVVAELEAADQVHLRTLLDGAVGTRATDRAQWDSLGYLIGDLRTALADGNLDKAKTLIVGQGTWRPQDQEGDLRVGVLEAITLETYWPQDLEVYYADVRKHRATHPYGYGVLRAQPWVGAFRTFESLEPPTKLRQGGYPKGLVVQADGDPMDRYEGGVVLAALLDHPLVVIEDSGDHEVYALAGNEVLDALVDDYLVDGVLPASKHTRIPGHVKRPDIPKD
>NZ_CP016793.1|WP_065913531.1|527787_529020_-|cytochrome-P450
MTSSATEPGVDTFPYKRQCPFTPPAQYAQMAEEDVVEVTLTGSGLRIWTISGYHTIKQLLTDPRISASRKHDNFPFYFIAPPEFRTETSFIGYDNPEHTKTRRKAAVTFTNRQVKRLRGRIQEIVDEYIDKILTMTPPIDFHREFSLAVPMTVICELLGIPQDEHDFFIEHGTCLLGGHSTPEQRQAAIVEVNAYVDKLITLKEKEPGEDLLSRAMAEYAASGEEYTRRDLFNMIRLLMNGGHETTASMLSLGTAALLEHPDQLQLLLDDPEGMIEPAVEELVRIATIGDTAIPRVALEDIEIAGKTIKAGDGILCLGLNGNRDPEIFPEPEKLILERGTRKHLGFGHGLHHCIGADLARLEMQLVWTTLFQRIPSLRLAKPFLEIPRKEGAVIYGLWELPVTWDLPAED
>NZ_CP016793.1|WP_065913532.1|529048_529807_-|SDR-family-oxidoreductase
MSDAPFAGQQVVVTGGGTGIGRAAALAFADLGAANVIITGRRENRLTEVVALHPAITAVVADVTTEEGAGKVADAVKLGGGKVDVLVHNAGIFRFTPVAGFDLGTARDVLETNLVGPLVLTAALLPQLTSPGGSIVFVSSNAGHIAVPGGGVYGASKAAVDSLVRSWALELAPQGIRVNAVAPAAVRTEVYAANGLSPEEVEGYFGFQASQTPLGRTGEVDDVVPWITRFAEPASSWVTGQIITLDGGADLA
>NZ_CP016793.1|WP_065913533.1|529906_530230_+|hypothetical-protein
MEIAGQWRVRVGRPGGETESELDFAEDGTATLVKGGRGSGTWTATGAGTFSYRITEEMTDPAGTVEINQDAVLNGDAFVSSGITTVRLADGSTIREAHVRITALRRT

Crispr_ID: NZ_CP016793_3

• CRISPR_ID: NZ_CP016793_3
• CRISPR_location: 1314013-1314110
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016793_3

Consensus_repeat	Method
CAGGCGACTCGGCCCCCTCCACGG	CRISPRCasFinder

spacers of NZ_CP016793_3

>3.1|1314037|50|NZ_CP016793|CRISPRCasFinder
GCATCCGGTTGCGCAGGCGGCTCGCCTGCTCTGCGGGCTTGCCGGTCACC

CRISPR arrays and Neighbor proteins around NZ_CP016793_3

CRISPR arrays

The CRISPR arrays of NZ_CP016793_3

>merge|NZ_CP016793|3|1314013-1314110|CRISPRCasFinder
CAGGCGACTCGGCCCCCTCCACGGGCATCCGGTTGCGCAGGCGGCTCGCCTGCTCTGCGGGCTTGCCGGTCACCCAGGCGGCTCGGCCCCCTCCACGG

>NZ_CP016793|3|3|1314013-1314110|CRISPRCasFinder
CAGGCGACTCGGCCCCCTCCACGG	GCATCCGGTTGCGCAGGCGGCTCGCCTGCTCTGCGGGCTTGCCGGTCACC
CAGGCGGCTCGGCCCCCTCCACGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_179953758.1|1309346_1309772_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065920860.1|1309125_1309293_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224393
NZ_CP016793.1|WP_065914243.1|1324307_1324826_+|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl|CDD|274679
NZ_CP016793.1|WP_170068095.1|1309879_1310797_+|tat-pathway-signal-sequence	unknown	unknown	gnl|CDD|379138
NZ_CP016793.1|WP_154697116.1|1322961_1324269_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065914234.1|1311883_1312228_-|MmcQ/YjbR-family-DNA-binding-protein	unknown	unknown	gnl|CDD|377256
NZ_CP016793.1|WP_065914232.1|1310793_1311462_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|212491
NZ_CP016793.1|WP_154697115.1|1313182_1313326_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_071812539.1|1314839_1315754_-|DMT-family-transporter	unknown	unknown	gnl|CDD|223769
NZ_CP016793.1|WP_065914241.1|1321416_1322919_+|beta-xylosidase	unknown	unknown	gnl|CDD|350108
NZ_CP016793.1|WP_065914240.1|1319954_1320956_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_071812540.1|1317175_1317610_+|transcriptional-repressor	unknown	unknown	gnl|CDD|223806
NZ_CP016793.1|WP_065914239.1|1317628_1319878_+|catalase/peroxidase-HPI	unknown	unknown	gnl|CDD|237891
NZ_CP016793.1|WP_065914231.1|1308184_1309129_-|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl|CDD|176228
NZ_CP016793.1|WP_065914236.1|1314195_1314768_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065914244.1|1324829_1325882_-|alkene-reductase	unknown	unknown	gnl|CDD|239243
NZ_CP016793.1|WP_065920862.1|1307045_1308227_+|amidohydrolase-family-protein	unknown	unknown	gnl|CDD|238624
NZ_CP016793.1|WP_154697951.1|1312268_1313069_-|TIR-domain-containing-protein	unknown	unknown	gnl|CDD|379328
NZ_CP016793.1|WP_065914237.1|1315752_1317138_+|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl|CDD|224089
NZ_CP016793.1|WP_065914233.1|1311509_1311872_-|VOC-family-protein	unknown	unknown	gnl|CDD|319911

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065920860.1|1309125_1309293_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	7.36663e-22
NZ_CP016793.1|WP_065914243.1|1324307_1324826_+|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl|CDD|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	2.62739e-08
NZ_CP016793.1|WP_170068095.1|1309879_1310797_+|tat-pathway-signal-sequence	gnl|CDD|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	0.000914869
NZ_CP016793.1|WP_065914234.1|1311883_1312228_-|MmcQ/YjbR-family-DNA-binding-protein	gnl|CDD|377256	pfam04237, YjbR, YjbR. YjbR has a CyaY-like fold.	1.28539e-13
NZ_CP016793.1|WP_065914232.1|1310793_1311462_-|SDR-family-oxidoreductase	gnl|CDD|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.24102e-34
NZ_CP016793.1|WP_071812539.1|1314839_1315754_-|DMT-family-transporter	gnl|CDD|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	2.38277e-08
NZ_CP016793.1|WP_065914241.1|1321416_1322919_+|beta-xylosidase	gnl|CDD|350108	cd08994, GH43_62_32_68_117_130-like, Glycosyl hydrolase families: GH43, GH62, GH32, GH68, GH117, CH130. Members of the glycosyl hydrolase families 32, 43, 62, 68, 117 and 130 (GH32, GH43, GH62, GH68, GH117, GH130) all possess 5-bladed beta-propeller domains and comprise clans F and J, as classified by the carbohydrate-active enzymes database (CAZY). Clan F consists of families GH43 and GH62. GH43 includes beta-xylosidases (EC 3.2.1.37), beta-xylanases (EC 3.2.1.8), alpha-L-arabinases (EC 3.2.1.99), and alpha-L-arabinofuranosidases (EC 3.2.1.55), using aryl-glycosides as substrates, while family GH62 contains alpha-L-arabinofuranosidases (EC 3.2.1.55) that specifically cleave either alpha-1,2 or alpha-1,3-L-arabinofuranose sidechains from xylans. These are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Clan J consists of families GH32 and GH68. GH32 comprises sucrose-6-phosphate hydrolases, invertases (EC 3.2.1.26), inulinases (EC 3.2.1.7), levanases (EC 3.2.1.65), eukaryotic fructosyltransferases, and bacterial fructanotransferases while GH68 consists of frucosyltransferases (FTFs) that include levansucrase (EC 2.4.1.10); beta-fructofuranosidase (EC 3.2.1.26); inulosucrase (EC 2.4.1.9), while GH68 consists of frucosyltransferases (FTFs) that include levansucrase (EC 2.4.1.10); beta-fructofuranosidase (EC 3.2.1.26); inulosucrase (EC 2.4.1.9), all of which use sucrose as their preferential donor substrate. Members of this clan are retaining enzymes (i.e. they retain the configuration at anomeric carbon atom of the substrate) that catalyze hydrolysis in two steps involving a covalent glycosyl enzyme intermediate: an aspartate located close to the N-terminus acts as the catalytic nucleophile and a glutamate acts as the general acid/base; a conserved aspartate residue in the Arg-Asp-Pro (RDP) motif stabilizes the transition state. Structures of all families in the two clans manifest a funnel-shaped active site that comprises two subsites with a single route for access by ligands. Also included in this superfamily are GH117 enzymes that have exo-alpha-1,3-(3,6-anhydro)-l-galactosidase activity, removing terminal non-reducing alpha-1,3-linked 3,6-anhydro-l-galactose residues from their neoagarose substrate, and GH130 that are phosphorylases and hydrolases for beta-mannosides, involved in the bacterial utilization of mannans or N-linked glycans.	4.66892e-07
NZ_CP016793.1|WP_071812540.1|1317175_1317610_+|transcriptional-repressor	gnl|CDD|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	3.06014e-32
NZ_CP016793.1|WP_065914239.1|1317628_1319878_+|catalase/peroxidase-HPI	gnl|CDD|237891	PRK15061, PRK15061, catalase/peroxidase.	0
NZ_CP016793.1|WP_065914231.1|1308184_1309129_-|NAD(P)-dependent-alcohol-dehydrogenase	gnl|CDD|176228	cd08267, MDR1, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	7.06609e-106
NZ_CP016793.1|WP_065914244.1|1324829_1325882_-|alkene-reductase	gnl|CDD|239243	cd02933, OYE_like_FMN, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include 12-oxophytodienoate reductase, pentaerythritol tetranitrate reductase, morphinone reductase, and related enzymes.	1.37549e-160
NZ_CP016793.1|WP_065920862.1|1307045_1308227_+|amidohydrolase-family-protein	gnl|CDD|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	2.02568e-72
NZ_CP016793.1|WP_154697951.1|1312268_1313069_-|TIR-domain-containing-protein	gnl|CDD|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	2.16341e-25
NZ_CP016793.1|WP_065914237.1|1315752_1317138_+|PLP-dependent-aminotransferase-family-protein	gnl|CDD|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	3.03224e-101
NZ_CP016793.1|WP_065914233.1|1311509_1311872_-|VOC-family-protein	gnl|CDD|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	7.263e-20

Protein sequences

>NZ_CP016793.1|WP_154697115.1|1313182_1313326_-|hypothetical-protein
MRIRTEDLAPSPRHPDSYENLVLLCAADSEIVTGERARATRRTCCWA
>NZ_CP016793.1|WP_154697951.1|1312268_1313069_-|TIR-domain-containing-protein
MKVTNEGTAPVRLDAVWFDTTPQVVVDNPHRPLPAVLHPGELFETWQAAHGVPAVPSPGHVARARLSDGTVVRSRPNTAVLPAGIVGGGGRPLTDLVGPVAAVNHDGGRLLDKERDVFISHASEDKDAVVRPLAHALRAKGLRVWYDEFELRIGDSLRRKIDEGIAHSRFGVVVLSPSFLTKGWTTYELDGLITRGNAAGGGQVVLPVLHGLTIGDLLRHSPSLADRVARDTAVTPVDVIADEIFEVVSRATVPRDRSPHVSDRSE
>NZ_CP016793.1|WP_065914234.1|1311883_1312228_-|MmcQ/YjbR-family-DNA-binding-protein
MATPNEFLDIAGALTEVQRSSGQQYDTFRVRGKVFGYYWPSTQTVGLKQTLSEQQALVAERPEVFEEQFTSGGFGWVVVYLEGIEADELAELVFEAWRLSAPEELVAVVPDLAR
>NZ_CP016793.1|WP_065914233.1|1311509_1311872_-|VOC-family-protein
MTRVKFELPADDLDRATAFYRDVFGWESLRLPFPYALVDTDGEPVDVADSDGGISPRTEFVQGPVLIVEVPSIDDVAPRVVASGGVLLNAKEQVGAYGFSQYVKDSEGSVLCLWESIQEA
>NZ_CP016793.1|WP_065914232.1|1310793_1311462_-|SDR-family-oxidoreductase
MNVVITGGGRGFGRTLARRFAEQGATVVVTARTLAAAQRTRDLLPDAHALQCDLTDPASVRRCAEQTAELLGHVDVLVNNGAGFLAESQADDDAIVRTILSGAAGTVLMTEHFLPLLRRSGRADVVTVVSLEAESRSDPAHIAHAAFHAAKAGQGRYAEIMSQRLRPEGIRMISLYPPDFEDGDGRDGVLTARSVADCVLFAVNQPRDCFIRSFHFEPLPVS
>NZ_CP016793.1|WP_170068095.1|1309879_1310797_+|tat-pathway-signal-sequence
MGRSAVRRSTSPVRRSTVRLMLRPILVACALALTACSAAVPAGPPAAAPLTHSPAAAPLIAVPEICPMPDSGFDCALQKRIQEAQLYAETRPGTVGIVLRDRHNGVVWRNKHAADKVWTASTIKLAMIVNLLERHRAGKIRLSTDDRRLMTAMLHSSDDDAADTLWQRYNGATFTAAFPEYGMTGLVAQRGYASSFPYWGFEKCTADDLDRLINHVLDEVDPADRAYIVEQMRSVGPEQQWGVWGPDSGVKNGWSQEDTGWVMNSVGFVGADQRYTLVIMNNLAGEGGYDEGRATDTEITRILFR
>NZ_CP016793.1|WP_179953758.1|1309346_1309772_-|hypothetical-protein
MAFEEKRAWAMAIVAAVGYAVYVVLVLGRAGGRPLAEVPYVDAALWTIGFGIVVGIVSGIWFGIASRREGGLQVDERDVEIGRFGDHVGQSFVVIGGVAALVLAMAEAPHFWIANVLYLCFALSAVLGSLAKIAAYRQGVR
>NZ_CP016793.1|WP_065920860.1|1309125_1309293_-|helix-turn-helix-transcriptional-regulator
MKQADLAAAIGVTRQTLIAIEQGRYSPSLEVAFRIARVFGVPLEEVFQYPEEETT
>NZ_CP016793.1|WP_065914231.1|1308184_1309129_-|NAD(P)-dependent-alcohol-dehydrogenase
MKAVVQRRYGSAVLGDLDVPVPGQGEVLLEVRAAGVDMGTWHLLSGKPYLLRVIGFGFRGPKSPVPGRDVSGVVTAVGPQVTEFAVGDEVFGTCDGAFAEYAVTQAKRLARKPAGLSFAEAAAVPISGGTALQGLRSVKAGQRVLVLGAGGGVGSYGVQIARSLGAHVTGVCSTKKVELVRSLGVHEVVDYTVADFTGTYDLVLDCGGHRSLSRLRDAAGKRGTVVIVGSETTEPIFGGFDRSLRALALNLFVPQKLVGLTSAERGDVFEELRVLIEAGEVKPAVDRTFPLSEALEAIDHVYSRRSAGKVVVTI
>NZ_CP016793.1|WP_065920862.1|1307045_1308227_+|amidohydrolase-family-protein
MLALRAARAFDGEHSLAGPVTVITENGTITAVEQGHPDVPGAEVVELGDATVLPGLVDTHVHLGADSENGALDRLPGFSAEHLDAVIEDSLDRHLKAGVTTVRDLGDRAWSVVEQRDRHRQRVLASGPPITSVKGHCWSMGGESAGEDALKRAVRERAERGVDVVKIMASGGFATPGTVVDDCQFTERELRVVVEEAHGCGLPVTAHAHSLASVQRAVAAGVDGIEHCTCLAGGAMVVPVELMDALAEADVAVCHTLGVTVEPPPFIREAFERMGMSLAAKIAAVGRMHDHGVRSVSGTDGGIAAGKPHGITAHALADMIEAGVPNAAVLASATSQAAKACGVSKGVLRAGWDADIIAVRGDPVRDIKAMHRVTTVVIGGQIVTTTLPADRRE
>NZ_CP016793.1|WP_065914236.1|1314195_1314768_-|hypothetical-protein
MQIEVASKRRKLNRPDAVVLDVTSRGPEPWVRFSPFYPHGGIPVPLSPGVVSESVEGVWQALKVFEKSDVDPAKLGVRSMKGLKRTVRRFGQVHGHRAGLHGSTLLDYRTARQEIYLPTYRWVLDHRLPDLVAELRALAGSTSVVLLDYTTNGDVDDLSTPLSHAALIADHVRRLDDGNSATTSGLPQAT
>NZ_CP016793.1|WP_071812539.1|1314839_1315754_-|DMT-family-transporter
MRAKSNVIVPPGVTLGALAVLGFSYSLPATRLAVMGLDPWFVAFGRAVGAAVLAIAYLVLSRASLPSVTQVRRLVVVAAGIVIGFPLFTSLALTTQTSAHGAVVIAVLPMSTAIWAVLRAHERPPLAFWLSSGAGLLAVLAFLAAGGGLSGSFSVADLYLLIAVVVCGLGYAEGGALSRELGGARTICWALVVALPVTIPVSLYTADFSRATTGVWFHFAYVTTISMFLGFVAWYAAMAAGGVAKIGQLQLAQPVLSLGWAALVLGEPVGWPALVTAAVVLVCVVLTQRSRVVSTNSVAEPAVR
>NZ_CP016793.1|WP_065914237.1|1315752_1317138_+|PLP-dependent-aminotransferase-family-protein
MNEDNAAMRVIEELRATARSGRAGDRMPSVRDLMARHKASPATVQQAIQRVAAEGLVEVRPGRGSFVAARNARATGQDLSWQSVALGEGRPGEDLVANLVAVPRPEVIQLSSGYLDPDLQPAEALGAALTRAARRPASWGRVPVEGKEELRAWFAKEAGGDLRAGDMTVCAGAQEALATVFRGLGQRGDTVLVESPTYLGAIAAARDAGLKVVPVPADEDGVRPDLLQAAFTHTGAKLFYCQPLHANPHGGVLSDERRPEVMRIVATAGAFLVEDDWARGFTIDGTAPPTLASQDTDGHVVHVRSLTKIAAPGLRVAAIGARGPAGRRLRTTRSRQDLYVAGPLQEAAIDFVTSPAWRRHLRTLHQALRHRRDALRTALATHLPEFTVAPTSGGLHLWVKLPDGLDDVELTTAAAARDVVVFPGRPWFAAEPPGNFLRLTYGGAPEHALVEGVRRLSDITR
>NZ_CP016793.1|WP_071812540.1|1317175_1317610_+|transcriptional-repressor
MPTASDFERMLRGASLRVTAPRMAVLSAVHNHPHADTDSIIGVVRQNLGAVSHQAVYDVLRALTGAGLLRRIEPQGSVARYEARVGDNHHHVVCRSCGSIADVDCAVGHAPCLDASDDHGFVIDEAEVIYWGTCPECTTAAKSS
>NZ_CP016793.1|WP_065914239.1|1317628_1319878_+|catalase/peroxidase-HPI
MSDSTDAKVSESKGECPVAHSRRSHPSEGGSNRDWWPNQLNLRILRKHPVQANPMGGDFDYSKEFLTVDLDELARDVDAVLTESKDWWPADFGHYGPFMIRMAWHSAGTYRTHDGRGGAGAGMQRFAPLNSWPDNGNLDKARRLLWPVKKKYGKKLSWADLMIFTGNRALETMGLKTFGFAGGRTDVWEPDEDVYWGPETEWLGGDTRYSGERDLESPLAAVQMGLIYVNPEGPNSNPDPLAAARDIRETFGRMGMNDEETVALIAGGHTFGKAHGAGDPSLVGAEPEGSLMDAQGFGWISTHGTGKGRDAITSGLEVTWTQQPTKWTNLFFKNLFEFEWELTKSPAGAHQWKPKGDAGANTVPDPEDGTLNRQPMMLTTDLSLRFDPIYEPISRRFAQDHEAFAEAFSRAWFKLTHRDMGPIQRYLGPQVPQEELIWQDRLPARDHELISTEDVAALKAKILETGLSVSQLVKTAWASASTFRQSDKRGGANGARIRLEPQRGWEVNEPDQLAQALRALEGVQEAFNSSATGGKKVSLADVIVLGGAAAVEQAAKAAGHDVEVPFLAGRTDATQEQTDAESFAVLEPKVDGFRNFGSKANPLPSEYLLVDKANLLGLSAPEMTVLVGGLRVLGANHGGSTAGVLTDKPETLTNDFFVNLLDMETEWKSVSEDEENFEGRDRATGAVRWTATRNDLVFGSNSELRAVAEVYASDDATDKFVVDFVAAWNKVMNADRYDIHEGVTQPENG
>NZ_CP016793.1|WP_065914240.1|1319954_1320956_-|hypothetical-protein
MSLPEPVIRPDAVDHYDRLLSSDALPSDSFCLTAVRGLGVDEALTRFGGIPRWREADLGETGVRSVNAYPDELLTVVAGEVSGWVLLAENNGWHGAKADVLQQLSRDTVVASAFWNVNFHSTLSLACGGELLGAFDFVIGTERPDALLPYLDGLAFDDPYRKCAESLAFVERVSGTRLTEEWATTPHQASAIVDLRRFLPKDPTVWLRSNEPELLDWAATASSDDVRAAAAETARAACAAVDIPAEATLDDVRRDYTRTLQLRWDRCAPPDPALDRIAQLQASVTRHRTEPAEERLAEKRAHARAAVIAARCDNPVDALAAARCNAVRAGRAR
>NZ_CP016793.1|WP_065914241.1|1321416_1322919_+|beta-xylosidase
MSLSRRPLPLLAALALVGAVTACTNAAVGDPVAAPSEQKPTSTGSTRKAPAPRNQIALKTELGRQSPGVVVAGAGDAPYNYAPAVMFDGGKVRTWWCSQLSAAPPGGDDVLYSEGPGLDGPMSTAVPVFSGSGTSFDAMHTCDPSLIKIGGTYYMYYTGASRDNHANGSSVGVATSPDGIGWTRANNGQSIVVPSGDVIRENTYGAGQQSAVYLDGWVYLMFTDTTGLASHQNGAGQYVLRSKDPTFTSGVEALSASGFQPVSATNKPRTRSVVEAFSADWMWIDAASTWAIAHSTDHGTTVTFWNKDFTRHPFSPVLIPGIWREGPGLARTPLGHAPVNAVDPCGRVALDVFRSTVDGAANAPTNITRFGLDVLGLRGCETSDEASALNGFAMPSPERTVDVVVGGKVVRFERRSVAEKFARTVLNDRPPGVDHLKVAARVPAGVPAVANPQGVVGLLLEDKLWVIGSAEAANLNSSDIRQVSAEQWERYERHQDLAAR
>NZ_CP016793.1|WP_154697116.1|1322961_1324269_+|hypothetical-protein
MTATKIRPQALAESVVPESNGERAVTGYVLGFLGSVAFLLLIPAGWARLDHLWAEDGARFAVDAIRFPAWQNVVDPYGGYLHLLPRLVAEVVALLPLEWTAAGFAVAAAVLRAVVALVTFAASGAYLRSTGLRFVLASLVVVLPAGNSETLNNMANLHWFLLYGVFWALLWRTGPRVPVALSVVLAALSSPLVFLLAPVALVRLFLPRKEVPIAFFGAVLTQGLVMLFAERTPYSQDAVDPVQVVLASLLRVPVVALTGSERVTAFYPAHGNLVVLGAVLVTGLPVVLGLWWGDRAGRALAAVATGYSALVILLCLVLNWSAVLQVQQPGVVISGQRYSIAPVLFLFTAMAVGLDAAPAVAWRRFTVRAGQWVVGILLVSSVIGYFQEPGPVLRGVPWDVSVEQGRAQCASGAADARLEHEPANWFFVVPCGQLE
>NZ_CP016793.1|WP_065914243.1|1324307_1324826_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MTNSTTHTRNLDQYGHAALPWSRAQDQLATETASADVPYFLNTVRPDGRPHSAGIGAVWFEDALYFVSGPGTRKSRNIAANPACTVSVRLTGLDLVLEGEAERVVDTAVLGRLAARYREAGWPAEVAGEAFTAPFTAPSGGPPPWYVYRLVLRGAHAVASREPYGATRWTFG
>NZ_CP016793.1|WP_065914244.1|1324829_1325882_-|alkene-reductase
MLLSSYRLGNLTLPNRLVMAPMTRSRAVDDKPTASTATYYAQRATAGLIVTEGLHPSAPSQSGPFTPGLHRDDQVEAWRTVTDAVHANGGRIFAQLMHGGRVSHPEIAGHHPAGPSAVALTTEVFAGGGRKPAPTPRAFASSEIAAEVQTFADAARRAVDAGFDGVELHGANGYLIQQFLSSNANLRTDGYGGSITGRIRFAVEAVEAAVDAIGAERVGIRFSPGGTVWDVVEDDVPALYSALVKALPDIAYIHVLATTDDETLMGLRKAWPTAFILNPGGQISPVEGTREQGERWLANGADLISYGRAYLANPDLVERFRLGLPLATADAETWFQGGDKGYIDFSSYRH

Crispr_ID: NZ_CP016793_4

• CRISPR_ID: NZ_CP016793_4
• CRISPR_location: 1606838-1607108
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NZ_CP016793_4

Consensus_repeat	Method
GTTGTCCCCGCGCACGCAGGGGTGGTCC	CRISPRCasFinder

spacers of NZ_CP016793_4

>4.1|1606866|33|NZ_CP016793|CRISPRCasFinder
CAGCTCCGGCACTTCCTTGCCGAGGTAGAAACC
>4.2|1606927|32|NZ_CP016793|CRISPRCasFinder
CAGTTCGGTCAGCTCGTGTTCGACACGATGAA
>4.3|1606987|33|NZ_CP016793|CRISPRCasFinder
GTACTCGGCTTCCATCTCCCAGTCGAGGCCGAT
>4.4|1607048|33|NZ_CP016793|CRISPRCasFinder
CGCCAAGGAGATGACTGACGTCTTCGCCCGCGG

CRISPR arrays and Neighbor proteins around NZ_CP016793_4

CRISPR arrays

The CRISPR arrays of NZ_CP016793_4

>merge|NZ_CP016793|4|1606838-1607108|CRISPRCasFinder
TGTCGTCCCGCGTACGCGGGGGCGGTCCCAGCTCCGGCACTTCCTTGCCGAGGTAGAAACCGTCGTCCCTGCGCACGCGGGGTGATCCCCAGTTCGGTCAGCTCGTGTTCGACACGATGAAGTTGTCCCCGCGCACGCAGGGGTGGTCCGTACTCGGCTTCCATCTCCCAGTCGAGGCCGATGTTGTCCCCGCGCACGCGGGGGTGGTCCCGCCAAGGAGATGACTGACGTCTTCGCCCGCGGGTCGTCCCCGTGCACGCGGGGGGTGGTC

>NZ_CP016793|4|4|1606838-1607108|CRISPRCasFinder
TGTCGTCCCGCGTACGCGGGGGCGGTCC	CAGCTCCGGCACTTCCTTGCCGAGGTAGAAACC
GTCGTCCCTGCGCACGCGGGGTGATCCC	CAGTTCGGTCAGCTCGTGTTCGACACGATGAA
GTTGTCCCCGCGCACGCAGGGGTGGTCC	GTACTCGGCTTCCATCTCCCAGTCGAGGCCGAT
GTTGTCCCCGCGCACGCGGGGGTGGTCC	CGCCAAGGAGATGACTGACGTCTTCGCCCGCGG
GTCGTCCCCGTGCACGCGGGGGGTGGTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_154697179.1|1610016_1610160_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065914455.1|1610785_1611529_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187628
NZ_CP016793.1|WP_170067884.1|1600961_1601519_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697174.1|1601563_1601977_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697178.1|1609840_1610020_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065914453.1|1604312_1604900_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|274357
NZ_CP016793.1|WP_065920909.1|1607949_1608696_-|GAF-and-ANTAR-domain-containing-protein	unknown	unknown	gnl|CDD|377145
NZ_CP016793.1|WP_065914458.1|1613428_1614154_+|hypothetical-protein	unknown	unknown	gnl|CDD|197715
NZ_CP016793.1|WP_071812549.1|1611521_1612247_+|recombinase-family-protein	unknown	unknown	gnl|CDD|239737
NZ_CP016793.1|WP_071812547.1|1605694_1606153_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697181.1|1612983_1613283_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065914449.1|1595584_1595794_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697177.1|1609669_1609825_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697176.1|1609108_1609471_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697175.1|1602933_1603140_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697171.1|1595026_1595167_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697172.1|1595165_1595462_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_083267858.1|1596270_1599405_-|RHS-repeat-associated-core-domain-containing-protein	unknown	unknown	gnl|CDD|274730
NZ_CP016793.1|WP_170067885.1|1606255_1606801_-|hypothetical-protein	unknown	unknown	gnl|CDD|153440
NZ_CP016793.1|WP_154697180.1|1612373_1612886_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065920909.1|1607949_1608696_-|GAF-and-ANTAR-domain-containing-protein	gnl|CDD|377145	pfam03861, ANTAR, ANTAR domain. ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	4.37802e-16
NZ_CP016793.1|WP_065914453.1|1604312_1604900_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	3.29927e-28
NZ_CP016793.1|WP_065914455.1|1610785_1611529_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187628	cd05370, SDR_c2, classical (c) SDR, subgroup 2. Short-chain dehydrogenases/reductases (SDRs, aka Tyrosine-dependent oxidoreductases) are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	7.30233e-77
NZ_CP016793.1|WP_065914458.1|1613428_1614154_+|hypothetical-protein	gnl|CDD|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	2.35982e-06
NZ_CP016793.1|WP_083267858.1|1596270_1599405_-|RHS-repeat-associated-core-domain-containing-protein	gnl|CDD|274730	TIGR03696, tRNA_nuclease_WapA, RHS repeat-associated core domain. This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.	1.86863e-17
NZ_CP016793.1|WP_170067885.1|1606255_1606801_-|hypothetical-protein	gnl|CDD|153440	cd07971, OBF_DNA_ligase_LigD, The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit. ATP-dependent polynucleotide ligases catalyze phosphodiester bond formation using nicked nucleic acid substrates with the high energy nucleotide of ATP as a cofactor in a three step reaction mechanism. DNA ligases play a vital role in the diverse processes of DNA replication, recombination and repair. ATP-dependent ligases are present in many organisms such as viruses, bacteriohages, eukarya, archaea and bacteria. Bacterial DNA ligases are divided into two broad classes: NAD-dependent and ATP-dependent. All bacterial species have a NAD-dependent DNA ligase (LigA). Some bacterial genomes contain multiple genes for DNA ligases that are predicted to use ATP as their cofactor, including Mycobacterium tuberculosis LigB, LigC, and LigD. This group is composed of Mycobacterium tuberculosis LigD and similar bacterial proteins. LigD, or DNA ligase D, catalyzes the end-healing and end-sealing steps during nonhomologous end joining. ATP dependent DNA ligases have a highly modular architecture consisting of a unique arrangement of two or more discrete domains including a DNA-binding domain, an adenylation (nucleotidyltransferase (NTase)) domain, and an oligonucleotide/oligosaccharide binding (OB)-fold domain. The adenylation and C-terminal OB-fold domains comprise a catalytic core unit that is common to most members of the ATP-dependent DNA ligase family. The catalytic core unit contains six conserved sequence motifs (I, III, IIIa, IV, V and VI) that define this family of related nucleotidyltransferases. The OB-fold domain contacts the nicked DNA substrate and is required for the ATP-dependent DNA ligase nucleotidylation step. The RxDK motif (motif VI), which is essential for ATP hydrolysis, is located in the OB-fold domain.	3.99588e-35
NZ_CP016793.1|WP_071812549.1|1611521_1612247_+|recombinase-family-protein	gnl|CDD|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	5.63244e-15

Protein sequences

>NZ_CP016793.1|WP_170067885.1|1606255_1606801_-|hypothetical-protein
MSIVVISLRCGDRMIVTSVPRSCPRESGVAAFEHHGRGSGELLGAHDDEGRLVYVGHVRTGFGREALVDLQRRLDPQGRSTSPYDLDMYREHARDARWVEPVLVGEVEFRQWTTDGHLRHSSWCGLRLDRDPSSVGLPAQPPDSSHRKGSADPQARTTGPVVGRGPRRRRAQRTTVSSRVC
>NZ_CP016793.1|WP_071812547.1|1605694_1606153_+|hypothetical-protein
MRLHQIAAVAGAVLLTTLVAPADAHAARIACGGAVSTQSIGVRGCISAERHEFTEIPYREITAHAVITNARTRASYVDYEAFFRVREGGSWIRLGGGRTIVRGKSTIGPIEIGDTERICAPVNVTAEIRVHVKPAGGSWSNWSGAMTRQCQT
>NZ_CP016793.1|WP_065914453.1|1604312_1604900_+|sigma-70-family-RNA-polymerase-sigma-factor
MTGTLICVRTVCLCARQGLDLGICVQTPSKLDADFVEFHDRHRVTFLKYARLRGLSSYDAEDVVSEAFLAMYRSRHAWRASTRPEAFAFTVVHGKLVDYCRKRDRQPRVVSATMDDERTADEVGGLIIRLDLERLLNQLPQQQAACVALRAFAGCDTGEISQYLGIAASAVRSHLQAARRRLRTELGVDLGEVTS
>NZ_CP016793.1|WP_154697175.1|1602933_1603140_-|hypothetical-protein
MVKELRSRSDLANPAEGVSLGKAVVELRQQDLTNGSNQISLKESAQKLDTWLKGAVPGYPPPVAPTGR
>NZ_CP016793.1|WP_154697174.1|1601563_1601977_+|hypothetical-protein
MSVIVALIALAAGIYVPLKIDDDAQDRERTRSCLEAVVDLRGTMGRLETGYATAPDSRQDRLAGWDSAINAFERTRVTCRNSQLPKPRKAQSAEALSEQVHTGRERALAESRDLSSATDTLDWTIDCIKHLTAYSAN
>NZ_CP016793.1|WP_170067884.1|1600961_1601519_+|hypothetical-protein
MPVEELFSVPGALVGCDGPTGDVTGEDDCRGEVRFQFAVDQPDFTVTQLAASRGTTQYTSVRRMRTDEELDIKVKYKNTGTIQQDDVVIKHALPAELTYIPGTTSVANSSTSNKWQKIDSNAVVERGINLGSHAPDGASYVRLSVRVSGHAQLRCGINQTVGVATAETQNGSKSQKSTIEIERTC
>NZ_CP016793.1|WP_083267858.1|1596270_1599405_-|RHS-repeat-associated-core-domain-containing-protein
MKRRLLRGLVLRAFSCAVITSLVASGASAPAVADPAKATIEVNRTPVGGAPPDRAWRGAGEVSALRSTCVSSNLGVLPWYPMERHQISDRLELLVNLDTRNVVLSYRELTVKGTGLNMSADRFYNAKAAYNWVHSGTEIGLEDPRFTVGNSRILHGPNGYCVEFPENADGTFAPAEHFRASLTKTPEGGYVVTFNDSGERWLFTGYGWFVSQTDRNGNANTNRYRPDGSLASITDSQGRVTTFNRDAEGRDSSLTDPTGQTFGDYVYDDDLISELTDRAGNKVKFGYDTERNLLTSVTDGRGNTWKLEYDPDYSLLSKLTKPTRDGTGASTTYADDGVNNTKVTDPNLHSSVHEFESPGRQTKATDALGHAQSRTWTANSDVNVTTNGLQHSTTYDYDPQNNLIGTKLATGAKNVVGYTDSAFPHLPTQITDASGNEVTRTYNGNGNLTSIRSTGLNADLEVLRYTERMGLVESKTDGKQAKTTYEYDDYGNLTKVIPPTPAKPTTFTYDALSRVDSVTDGNGKKIVYGYDKLDRVTTITHNGTVLQSNAFDANGNLTRTQTPDATRVFDYDPRNLLEKVTRGSEVVSYTYDKAGNVKTLTTPTGVAKYDYDEADRLKTLQDSYSGTTTFGYDDADRRTTTTFPGGAVQTAGYDNAGRQTSVTVTRPGGGELLKTTNRYTKPDGTDTDKIQVKTRGSSSRSFTYDGAGRLKTAPGTTYNYDNATNLLAGEGRTFTVNAADQATKAGDTTVAFDGAGNHASTTNPESRFTFSPTNQVLTGHAGTAQVLDVRYDTSDQTQPRTITETVGGNQVTHVLTHTALGVTETVDNGKRSSYTRDTQGLLIGLKDGAGARYGAVTDHQGSVIGLIDASGNLVAEYDYSPYGTVRATGAAASANPFRYIGAYQLQQGQYMMGYRVYDSAMARFRSPDPTGQESNPYNYAKGDPINNSDPTGALSGPGAAAWVGGVAGVAVGAALTLACPATAGLGCVGATAVVTGLTAGAGSALGASLAGGNSEQVSEAGITGIGGGVVKGLGKLSGVAGKLF
>NZ_CP016793.1|WP_065914449.1|1595584_1595794_-|hypothetical-protein
MLNRTTKSPQVRFWIITCAIYIALAVATVLLHDEVPWMGAAVGALGGSLILAALLGWWRRHPSNPDRVE
>NZ_CP016793.1|WP_154697172.1|1595165_1595462_+|hypothetical-protein
MPLRILGSISLLEVGSDERACPLINNASAGTADRAADHDLTDLVLVALADRGARSSTWSAERRSNDGRADPCQAPADVEKKVDAQLDAIEAARRAWPV
>NZ_CP016793.1|WP_154697171.1|1595026_1595167_-|hypothetical-protein
MVAMFLTSAAGVVALLLEWPLVVPIVLFLGACLAGVYVLKQSLRHR
>NZ_CP016793.1|WP_065920909.1|1607949_1608696_-|GAF-and-ANTAR-domain-containing-protein
MAAGDRPDALSRLDETAEALTVLRDSFTDEEPLDTALQRLADTTSGAIPDADAVTVSLMDLAQPRTAAATNPRLIEVDEKQYSANRGPCFESARTQRAVRAVVGEHLDEWPEFEAAAAEHAIRAYLSVPVLLPSSKSTQEQHLGSLNIYSYTAAAFDPFDEGLMRLFTTTASATIACAQRQQRSRDHISSLEQALVSRAVIDQAKGILMAVHSCTADEAFAMLVQRSQHENIKLRDIAKNLLDSVTSS
>NZ_CP016793.1|WP_154697176.1|1609108_1609471_-|hypothetical-protein
MLIDVQQPEPRCDLCIDTGTVTWQQPVPGADGALVLMEMNHPCVNGCSAGTGFPPLKAATSSTPMVAGGPPGTSPTPTSTTAPTGPGPALGPKSTPYRHPDRRDRHDGEGRRQQTTPGEA
>NZ_CP016793.1|WP_154697177.1|1609669_1609825_+|hypothetical-protein
MLDPVMAGMTDRVLGGLAELYGMDGEGSTLEDLVREHVGPAVDGYDVEAIN
>NZ_CP016793.1|WP_154697178.1|1609840_1610020_+|hypothetical-protein
MNTRLRDTGMSLDEHSGGGADGFIGDNLRELLYDAMFTAQLPLIIMRYRSYRANQSSRS
>NZ_CP016793.1|WP_154697179.1|1610016_1610160_+|hypothetical-protein
MTPVDIGVIAYTACLALAEVGYSFAWHELQDLLNRYGWPSELPGEPP
>NZ_CP016793.1|WP_065914455.1|1610785_1611529_+|SDR-family-NAD(P)-dependent-oxidoreductase
MIDEVVFITGASSGIGAGIAARFHARGARVVISGRDRLRLEAVATAHPGMSAIVMNVADPESVTQGMTELAAQVPHLTTLINNAGIQRTLDFSTSEPPRPADVEPEIATNFSGLVNVTAAALPLLRLAPRSRVVHVGSGLGFVPFAKVPVYSATKAAVHSFTLSLRRQLAGSTVTVVEIIPPVVDTPLHRNLPSTPPRAMPLDAFLDRVMRGLDAGKDEIAIGLGRASQLGARLAPKRLFSLINSGE
>NZ_CP016793.1|WP_071812549.1|1611521_1612247_+|recombinase-family-protein
MNDVFATPIAVLPLLCWSRRPLQPPRQLHRVTPQPPLRHPAEQPAAANEPIRIGYARCSTAQQDLDIQIEALTQSPVPQGVLREDQQPDQGRPESEEALALPYELRQAAPHQPVILTVHEPKRHARNGAELMALAASLDAAAVQLELLAGPLAGIYDPHGVGSMPFAVLTNAAQLDRNYIREKTSKGQHAVAAKGNHGERPKVTDNDLLIVARALRDKSVPIPEIVTKLTIKTGKNAGEHP
>NZ_CP016793.1|WP_154697180.1|1612373_1612886_-|hypothetical-protein
MLALSACLGAAVVPVTANAQVNGTSGSAQQMDGDGRTAANSWMRNNFPVSAVWVETTRYNTTTGRYDRAWRYGGARYYDNDFQLRNWMARNGFQAGPGATEFFEYDVIPALQTRGAARHPTLRLVWNSRSGALFYTWDHYQNFRYVGIYVRANDRARDPGFCNIEAPRCR
>NZ_CP016793.1|WP_154697181.1|1612983_1613283_+|hypothetical-protein
MKSPEVENISRYLSALIITVVSLVFGGIVRDDETNVGTPVLVNQVGSVATFRLTQRDKPWVTLLDRLLRTRGDRDDARLDRVVALGSALGGRGLGRLTF
>NZ_CP016793.1|WP_065914458.1|1613428_1614154_+|hypothetical-protein
MLWSEGAELVARLAALFELRGTDNPGLREFRGCTAVATGLTDALRGATRLVRAVRCSSLDEIGWVRTGLTPMSPIPAAGGVKFQVVLDTAVACATGETARLLDRAASGWQVRLLHGVPVEMVLIDDNAALLARKGDAAAEHVWFVRSSPLLEIMIDVFHTLWSLAAPVTGHIVMGLDDDGITEQDRALLVMLAAGATDVLIAEKLDLGLRTVQRRLQVLSGRLGARTRFQAGLNAAKRGWL

Crispr_ID: NZ_CP016793_5

• CRISPR_ID: NZ_CP016793_5
• CRISPR_location: 1629504-1629648
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP016793_5

Consensus_repeat	Method
GCAAAACCGCAGGTCAGCCCCGTTCCCC	PILER-CR

spacers of NZ_CP016793_5

>5.1|1629550|20|NZ_CP016793|PILER-CR
GGGGGCACCACGATGATCAA
>5.2|1629616|26|NZ_CP016793|PILER-CR
TAATGGGGCTGACATCGTGAGGAAAC

CRISPR arrays and Neighbor proteins around NZ_CP016793_5

CRISPR arrays

The CRISPR arrays of NZ_CP016793_5

>merge|NZ_CP016793|5|1629504-1629648|PILER-CR
AAACCGCTGGTCAGCCCCGTTCCCATCCTTTGGTACTCCCGCCGGGGGCACCACGATGATCAAGCATTTCCGCAGGTCAGCCCCGTTCCCCTAATGGGGCTGACATCGTGAGGAAACGCAAACCTGCATGTCAGCCCCGTTCCCC

>NZ_CP016793|5|1|1629504-1629648|PILER-CR
AAACCGCTGGTCAGCCCCGTTCCCATCCTTTGGTACTCCCGCCGGG	GGCACCACGATGATCAAGCA
TTTCCGCAGGTCAGCCCCGTTCCCCTAATGGGGCTGACATCGTGAG	GAAACGCAAACCTGCATGTCAGCCCC
GTTCCCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_083267866.1|1631229_1634670_-|hypothetical-protein	unknown	unknown	gnl|CDD|227250
NZ_CP016793.1|WP_065914464.1|1619680_1620118_+|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NZ_CP016793.1|WP_065914477.1|1639074_1639776_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065914470.1|1630021_1631230_-|hypothetical-protein	unknown	unknown	gnl|CDD|227261
NZ_CP016793.1|WP_154697188.1|1637852_1638863_-|hypothetical-protein	unknown	unknown	gnl|CDD|227059
NZ_CP016793.1|WP_179953760.1|1622223_1622787_+|anti-sigma-factor-antagonist	unknown	unknown	gnl|CDD|132914
NZ_CP016793.1|WP_154697189.1|1640020_1640188_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697186.1|1626499_1626727_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697184.1|1625638_1626064_-|anti-sigma-factor-antagonist	unknown	unknown	gnl|CDD|132914
NZ_CP016793.1|WP_065914472.1|1634666_1635371_-|DUF4194-domain-containing-protein	unknown	unknown	gnl|CDD|372745
NZ_CP016793.1|WP_065914473.1|1635367_1636825_-|DUF3375-family-protein	unknown	unknown	gnl|CDD|371764
NZ_CP016793.1|WP_154697185.1|1626266_1626488_-|hypothetical-protein	unknown	unknown	gnl|CDD|273042
NZ_CP016793.1|WP_083267865.1|1626976_1629142_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
NZ_CP016793.1|WP_065914466.1|1621649_1622000_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697187.1|1637209_1637887_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_170067886.1|1623887_1624472_+|GAF-domain-containing-protein	unknown	unknown	gnl|CDD|379056
NZ_CP016793.1|WP_154697183.1|1620309_1620510_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_071812551.1|1620074_1620344_-|hypothetical-protein	unknown	unknown	gnl|CDD|132914
NZ_CP016793.1|WP_071812553.1|1639772_1640036_+|WhiB-family-transcriptional-regulator	unknown	unknown	gnl|CDD|376791
NZ_CP016793.1|WP_065914474.1|1636803_1637112_-|hypothetical-protein	unknown	unknown	gnl|CDD|378233

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_083267866.1|1631229_1634670_-|hypothetical-protein	gnl|CDD|227250	COG4913, COG4913, Uncharacterized protein conserved in bacteria [Function unknown].	2.68086e-83
NZ_CP016793.1|WP_065914464.1|1619680_1620118_+|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.11295e-12
NZ_CP016793.1|WP_065914470.1|1630021_1631230_-|hypothetical-protein	gnl|CDD|227261	COG4924, COG4924, Uncharacterized protein conserved in bacteria [Function unknown].	3.96848e-35
NZ_CP016793.1|WP_154697188.1|1637852_1638863_-|hypothetical-protein	gnl|CDD|227059	COG4715, COG4715, Uncharacterized conserved protein [Function unknown].	1.52422e-17
NZ_CP016793.1|WP_179953760.1|1622223_1622787_+|anti-sigma-factor-antagonist	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	4.11062e-21
NZ_CP016793.1|WP_154697184.1|1625638_1626064_-|anti-sigma-factor-antagonist	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	3.18026e-19
NZ_CP016793.1|WP_065914472.1|1634666_1635371_-|DUF4194-domain-containing-protein	gnl|CDD|372745	pfam13835, DUF4194, Domain of unknown function (DUF4194).	1.43843e-30
NZ_CP016793.1|WP_170067886.1|1623887_1624472_+|GAF-domain-containing-protein	gnl|CDD|379056	pfam13185, GAF_2, GAF domain.	3.02219e-10
NZ_CP016793.1|WP_154697185.1|1626266_1626488_-|hypothetical-protein	gnl|CDD|273042	TIGR00377, Anti-sigma_F_factor_antagonist, anti-anti-sigma factor. This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions].	5.32658e-06
NZ_CP016793.1|WP_083267865.1|1626976_1629142_+|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	3.50474e-08
NZ_CP016793.1|WP_065914473.1|1635367_1636825_-|DUF3375-family-protein	gnl|CDD|371764	pfam11855, DUF3375, Protein of unknown function (DUF3375). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.	1.24841e-63
NZ_CP016793.1|WP_065914474.1|1636803_1637112_-|hypothetical-protein	gnl|CDD|378233	pfam09660, DUF2397, Protein of unknown function (DUF2397). Proteins in this entry are encoded within a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria).	0.00451203
NZ_CP016793.1|WP_071812551.1|1620074_1620344_-|hypothetical-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.34898e-10
NZ_CP016793.1|WP_071812553.1|1639772_1640036_+|WhiB-family-transcriptional-regulator	gnl|CDD|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.24832e-13

Protein sequences

>NZ_CP016793.1|WP_083267865.1|1626976_1629142_+|tetratricopeptide-repeat-protein
MTSQDRSGEVHNEVTATELSGVVIQAHTVAVGDVHHHHPPAVPERPVPRQLPAAPAAFVGRVDELAELASALEQEEGKVVISALAGTGGIGKTWLALHWAHTHVDRFPDGQLFVDLHGFSPAGVPVSAEMAVRWFLDALGVEPNRIPPELDAQAALYRSLVAGRRMLVMLDNAATAEQVVPLLPGSPTCTVLITGRTRLASLIDRHGCRHLTLGVLTRHEALALLVERLGARRVAAEADSVDELVALCGNYPLALAIIARTAATRPGVPLAELTGELRNLGLETLDHDTDPAASLPTVLSWSLRTLTADQRTMFSLLGIAPGPDTTLAAAVALTGLPRNRARKALSALEEASLLERRPRGRYTMHDLVRGYANVTAEELPTAEREAALTRAMEFYLHTALAADRLLAPHRPLPPIGSPCVPPLPLPDVEAAAAWLQDEHATLLATQRAAVAHRRHDIVWHLADALNAFHTRRGHLRDALATWQAAADATDHLADPLTRIRTYRALGHACARSGLHKQATENLNNALKLAEHHHEPAEQAHTHEALASAWEQRGDDQRALEHARRCLDLYRTLGRPRWEADALNLVGWHAARSGELETARQHCEAALALHRHHNDTYGEAATLDSLALVAHRAGDHRQAVDHYHHAIALLRSLGDAYEVAGILDRAGSSLFALGSKEKARADWSEALRLYQEQGRDTEADRVQRQLDDLDNNQARPKAENAE
>NZ_CP016793.1|WP_154697186.1|1626499_1626727_-|hypothetical-protein
MLRAGSVRNIGRRTGSDLSEGCSVSSSEAASTASVQTSDHDGVLVAMVSGELDMISVDAVGTTLFDHLAVVRMAW
>NZ_CP016793.1|WP_154697185.1|1626266_1626488_-|hypothetical-protein
MDFMGSSALSMLLELLGRSQREGVGFAIVAAQTAALRPMMASALSQVLPLSQSVDEAVKAIRKDWESGRQSVQ
>NZ_CP016793.1|WP_154697184.1|1625638_1626064_-|anti-sigma-factor-antagonist
MHNSTGSVFAPTLFQDEIAIVTVKGEIDTVADEILLAEAVDVLTRPPAGLVIDLQAVTFFGSSGINFLVAVRHQAQSRGVPFAVVAAQNAVVRPLQLTCVDRIIAPYPSLSDALAAVRATGSPPAQRKQLTRPAASATPSE
>NZ_CP016793.1|WP_170067886.1|1623887_1624472_+|GAF-domain-containing-protein
MDGAFVSLIDGPRFQTSLYASDVAAHIESVQFSLGEGPCFEAFATCSPVLAPDLAHASAPGWSAFAAAMAGRPIGAIFAFPLRADAIGIGVIGFYCRRARPFSDDELAIALEVADLMTVVLLGPQLGSGDSSRGVLAPDHAQLHKATGMLVATVGVSAAEAVARLRGHAFVVSRSVDEVAQAIVTGMISPWELD
>NZ_CP016793.1|WP_179953760.1|1622223_1622787_+|anti-sigma-factor-antagonist
MRDLRRIAATRPVIEQAKGMIMLMRSCGADDAFAVLREISQHTNIKLHDVAAVVVAVGSGCTPCEQDDVTRSVLAELLDGVAVLHVGGEIDITTADPLRAELSTRLAAGDDLVVGCTEVTFMDSTGLSALVTAQNHASRRGTRLIVVGNHHAVLRPLQITHLDAVLTIAATSADALAHLERRDDKAP
>NZ_CP016793.1|WP_065914466.1|1621649_1622000_+|hypothetical-protein
MMTPLEDERTAAWVLQTAVHAVLAAVFNDEPCELHTECGCVAQAELASWDRAAILTTAVEPWLRGLHPELLAELRDGVVCARIGAADEAVDHLFRVWEPLVVMAEAELDLPTRRSR
>NZ_CP016793.1|WP_154697183.1|1620309_1620510_+|hypothetical-protein
MPEEPKKSTASKSMTPTGGGVVVEHGVGLGEQSLVGGHVYLASHRDDRDLVLDHNVSGHLLHGTLG
>NZ_CP016793.1|WP_071812551.1|1620074_1620344_-|hypothetical-protein
MEAVDFFGSSGINLLLAVQQQAWHNGVPFAVVAAHNAVVRPLQLTRTDKIFSLFPTAQCSGRYAVPRTWCRRRDVARQPHGTSASVLTT
>NZ_CP016793.1|WP_065914464.1|1619680_1620118_+|ATP-binding-protein
MNSDAFPDQVHVLELDVEVADLGGVRRWAESTLVGLHPDDLVDVLLVITELVSNVYDHARFPARLQLRKSDMPCVVTVSVEDVSPTAPVLRPPSTDSPRGRGLVIVNQIAKQWGAAQRVIGKSVWALIPCSLTSSKRTQTSHGAV
>NZ_CP016793.1|WP_065914470.1|1630021_1631230_-|hypothetical-protein
MHEPDHVLDKIRARYRNIWRDRLLLGADTAFLFALAAPSAQMIARDSDTVSRWMREWRTWSAAHPTARLRGGSRRTVVGTQEVFTHLDLPTIDDLVSLDQDLADHWLRANARWARLQKLPGGAAEERLRPHLQQIVELDDADFEILLGATTWFTENPRSGLTIRQVPVPGMHTKWLSRHRRLVLACLSIPDLGGDIDQNDEELGQDNLDPLGLKALPVHVDVILADPVDRALVGGLRHLSAPLPEIDALPVHPETVLIVENKESAYLVPDRPRTVVVHSLGNHLNVLDEISWLDGARHVYWGDLDRAGFTLLSRARARMPHLASVLMDQTTLEEYKALAVEDGTRVDTPEPNLIAFEAAALAELLTAHGTYLRLEQERLPSAFVLDQLNRAMEGHGSGQVRY
>NZ_CP016793.1|WP_083267866.1|1631229_1634670_-|hypothetical-protein
MTAPRAAFRKDQQTALFPVADEEGAAQFRIIEVQILNWGAYSGLQSMIVARSGTAIVGPSGRGKSTLLDAMASVILPNPQEFNQAARDDRGKKRERTVYSYARGHTDQRQDENRRSATTNYLRPPGAPGFPSGAAITWETGDGRRVTSFRLAWVGQDADGPEAVNATTVYGFVHDRFDLAQLNGITAVRQGASPLSKTSLERLVDLDRGDVVDPSQARVHAKMRSVMGMGSTDESQRLAMQLLRRAQASKGIFSINALFKDFVLTEPLALTRWDVALEAYREASRLYEEFETARRRTETLAPLPAIAERYYAAGSDYVAKNRLLIGGDDSPTRFQVWHAEKVAEWAETAIDDNRLAKAEADEEHAAAAKTAGTAERHEKNTIDQLTAAGGDRSGLIKLQLKHAKETLERLEAERQQLENRLSVFKLPLPTSPGDVTLTHDSLDDLAVQETEALKGASDTATKAAGRLWQLRKDAEAKKREITGLRARRNLIPEDADTRRNRIASSLGIEIDRLRYAGELLQLKPEHRRWEKAVVGLLLPLSSTLLVDSRDFARLRRYVHDNDMQGTVTIAPAASGSPGPAPVDGGIPALLDIADHPFQGWLASELNETANYLCVETEVELDDQRPTWARGSITPAGMRTGSRHRFTKDDRRLRYPWIGWDTRWLLQDLDDELESIEREVQIADVSTNEANLRHESARNRLNELRALRTNLTWERIDTSVAREQIGEFENQLAQANSPEVAHLTELLQKQRERAVAASREVKRLEEEQERLDKQWGDLVSVVDDAKDRVDAGPPLSADERAALAPTPFNAPTEAAGVTASLRAAMENLRGQIEQHKQDREKLEVAVVGHIAAYRNLDERTARETDGTIDSLPALLAIYRQLVTDDLPRAKDAWLAKVDEDMNRQLRGLLVQIEDDARSIKRGLVPINDVLCHVRFRTEATLSIEPVERPSGDLKDFRQIITRYTSNTVGMDTERDIDQIEKSFTRLRRHLARLDDQSRAGDAWRRKVFDAREHVEFQAIESRPDGVKVVHDGVSGMSGGEGQELIAFILGAALRFRLGEGHEGPPSYASVILDEGFVKADSDYTGRSLSALQALGFQLIVGAPREKATAFEDYVASVAYINVDVDDLTRVRIYPMTMKEALSLEEDP
>NZ_CP016793.1|WP_065914472.1|1634666_1635371_-|DUF4194-domain-containing-protein
MSERVDVPYDDSTSSDDMDQYGFEDDEPDQPGSSRLPTAARRALTTLLTKRFITRSRNRSAWDALLTYETEIRERLADMYLLLVVDKDYEVAFKRQDPADDAPRLLRRDKPLHRDASLLLIHLRKEHTYTDATDDPVVITRAQVAEFLRPFREDGDGDEAKFQRRVEAAVRAVADLKLLTPDPDADYLFTVSPAVVPLIGADEVMRMEQYFSQAAGEAGVPDESGHEGSGEDLA
>NZ_CP016793.1|WP_065914473.1|1635367_1636825_-|DUF3375-family-protein
MEITSELIRAALGTNPTLTLLKAYSRDWVLPLFAEHLEQLDGSVSAEWFHERVAEARAQIRDWQGNVTPAEHCRDWVEKRWLETETLNGRLRYRLSPHTLRALRFVRELVEGETTVSGARLGSISHAVRLLADMTNPDREVQVRRIDQEIAELHKRRDDIASGRVRLATLEEMKQQLREILAMTRSLPADFRQLRTMVEDRHQEVARRAMAQGSPKADLVEEYLRENDLLSKTSQGTAYVGFSRLLSSRQSEQLRADIDQILGQAFALEHMTAAQREELDSMLSTLLAAELDVQNSYLRWSASLRRFLTRAAHGRHQRLISLADRALHAGATWVQAEPGQRYVPQDVLGVGPLAVVDISQTQLWRDHGPQEVIVEVTEQRRTLPTEDREALRLAAGTSPRAVGRTINKLLASQSVVIGAEVFDAIPAEFQRLGALVSLLDLAVVHGQVDIDLVETVRLSGNRGSVLMIALPHLAFDTPVPTKETP
>NZ_CP016793.1|WP_065914474.1|1636803_1637112_-|hypothetical-protein
MIDHDEAPEMEAPADPWSALLPGQELVPAYLTSRFAAQYRVIVEVLLAEQDTSLTGLSYDEVASEVLHLDARLVRWRILPRCRKPPAGGEGSDRRSWRSRVN
>NZ_CP016793.1|WP_154697187.1|1637209_1637887_-|hypothetical-protein
MTSSYDVLRIAERLCADDRDDEALTWLERGLTDFEPDSRLRDLAAGIHVRAGRLDRAGEMLWSNFTDRPSLETFRALRDATAGDFPHWRERALAFLAVLPPVKGSWSSGRSTLVEILLADDENEAAWQAAVDGGCSEGLWLRLARVRAASHPADAIPILLRAADRAIEARNRDSYKAAVRLLAEVKALFARCDRDDDFRAHMTVVRAAHRTKWALRQELDWARLP
>NZ_CP016793.1|WP_154697188.1|1637852_1638863_-|hypothetical-protein
MSMVRKLADERSFERGERYLAAGQVRRVTVDGSTVTATVDGTRTYRVRLDVTPKGLCGRCSCPYGADGVSCKHCVATSLAWLEQGGEMGEPRAEPLSDKRLRLFLSGCDQEWLIEQLMTAAKSDRVLRARLAAAAGQKNAFDDRDIRDRLERAIDIPDFVDYGGAYGYFLHVGEALGEVERLIGAGFADAAIILAEYALELLESSAERVDDSDGGLSEAIARVEEIHLAACEAGSPDPVELAERLVARAVSTDYELFLDVLPAYEEVLGSAGLARYRELVEQGWRTLPPKKPDDYSARRFVITHLMENLAESSGGRWADRGAGTGRDELLRRAPHR
>NZ_CP016793.1|WP_065914477.1|1639074_1639776_+|hypothetical-protein
MIERRFLAMTAGPQPLTLDCAALGCGLPNEELPLDRVRVLLLKRQTSWVSKDAVWKELVRKAHAAPEPWTTIAAAMMMPGLKHIAGKLGSRFCGDRNDLDSEILEGFLQALDLADARSPKIFGQLYWAAFRRGHEACNSERRRAMSRSELTDTAIDIRTADGHPDLVLAGAMLSGVITPHEADLVSDVLLDHGDRSTAAKRRGLSRHQVAAQLNTASRHLADYLLGGPLRPAV
>NZ_CP016793.1|WP_071812553.1|1639772_1640036_+|WhiB-family-transcriptional-regulator
MTTLVALRAPKWHVHAACRNADREIDWIDAELGSKAAKGCKEICRLCPVRLTCAITALTRDESYGVWGGMDQVDREALRHADAQIAA
>NZ_CP016793.1|WP_154697189.1|1640020_1640188_-|hypothetical-protein
MPQHYVADNRRLLQAKTLSFGAVNEIDLEDDVYGFMLLLAAGPLPGAGSCVHAAI

Crispr_ID: NZ_CP016793_6

• CRISPR_ID: NZ_CP016793_6
• CRISPR_location: 2013283-2013417
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP016793_6

Consensus_repeat	Method
GACGACCTGCGTGGCGTCCGGGTT	CRISPRCasFinder

spacers of NZ_CP016793_6

>6.1|2013307|33|NZ_CP016793|CRISPRCasFinder
CTGCTGCGGCGCGGCAGGCGTCTGACCAGGCGA
>6.2|2013364|30|NZ_CP016793|CRISPRCasFinder
GTGGGAAGCCTGCGGCTGCCCTCCTCCCGG

CRISPR arrays and Neighbor proteins around NZ_CP016793_6

CRISPR arrays

The CRISPR arrays of NZ_CP016793_6

>merge|NZ_CP016793|6|2013283-2013417|CRISPRCasFinder
CACGACCTGGGTGGCGTCCGCGTTCTGCTGCGGCGCGGCAGGCGTCTGACCAGGCGAGACGACCTGCGTGGCGTCCGGGTTGTGGGAAGCCTGCGGCTGCCCTCCTCCCGGGACGACCTGCGTGGCGTCCGCGTT

>NZ_CP016793|6|5|2013283-2013417|CRISPRCasFinder
CACGACCTGGGTGGCGTCCGCGTT	CTGCTGCGGCGCGGCAGGCGTCTGACCAGGCGA
GACGACCTGCGTGGCGTCCGGGTT	GTGGGAAGCCTGCGGCTGCCCTCCTCCCGG
GACGACCTGCGTGGCGTCCGCGTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_065914756.1|2008884_2009403_-|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224439
NZ_CP016793.1|WP_083268755.1|2005075_2005741_+|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|313370
NZ_CP016793.1|WP_065914755.1|2007736_2008159_+|DUF4307-domain-containing-protein	unknown	unknown	gnl|CDD|379491
NZ_CP016793.1|WP_065914762.1|2016004_2017225_+|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|181146
NZ_CP016793.1|WP_065914766.1|2021361_2022528_+|polysaccharide-deacetylase	unknown	unknown	gnl|CDD|200598
NZ_CP016793.1|WP_065914763.1|2017393_2017603_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_063798906.1|2023975_2024098_+|pyrroloquinoline-quinone-precursor-peptide-PqqA	unknown	unknown	gnl|CDD|369666
NZ_CP016793.1|WP_065920948.1|2005707_2006508_+|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|313370
NZ_CP016793.1|WP_065914760.1|2013565_2014933_-|cystathionine-beta-synthase	unknown	unknown	gnl|CDD|273464
NZ_CP016793.1|WP_065914754.1|2006770_2007640_-|mycothiol-conjugate-amidase-Mca	unknown	unknown	gnl|CDD|132487
NZ_CP016793.1|WP_065914758.1|2011092_2012238_-|cystathionine-gamma-synthase	unknown	unknown	gnl|CDD|236104
NZ_CP016793.1|WP_083267897.1|2006504_2006768_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065914764.1|2017599_2017986_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379326
NZ_CP016793.1|WP_083267898.1|2019216_2020605_+|hypothetical-protein	unknown	unknown	gnl|CDD|227268
NZ_CP016793.1|WP_065914767.1|2022634_2023672_-|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl|CDD|369642
NZ_CP016793.1|WP_065920951.1|2009477_2010659_+|4-hydroxyphenylpyruvate-dioxygenase	unknown	unknown	gnl|CDD|273528
NZ_CP016793.1|WP_053739481.1|2008346_2008841_+|transcription-elongation-factor-GreA	unknown	unknown	gnl|CDD|234693
NZ_CP016793.1|WP_065914765.1|2018081_2018885_-|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl|CDD|378959
NZ_CP016793.1|WP_065914757.1|2010713_2010962_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_083268756.1|2020751_2021309_+|class-F-sortase	unknown	unknown	gnl|CDD|320678

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065914756.1|2008884_2009403_-|Lrp/AsnC-family-transcriptional-regulator	gnl|CDD|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	3.30086e-22
NZ_CP016793.1|WP_083268755.1|2005075_2005741_+|nucleotidyltransferase-domain-containing-protein	gnl|CDD|313370	pfam10127, Nuc-transf, Predicted nucleotidyltransferase. Members of this family of bacterial proteins catalyze the transfer of nucleotide residues from nucleoside diphosphates or triphosphates into dimer or polymer forms.	1.55503e-31
NZ_CP016793.1|WP_065914755.1|2007736_2008159_+|DUF4307-domain-containing-protein	gnl|CDD|379491	pfam14155, DUF4307, Domain of unknown function (DUF4307). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	1.32472e-33
NZ_CP016793.1|WP_065914766.1|2021361_2022528_+|polysaccharide-deacetylase	gnl|CDD|200598	cd10976, CE4_CDA_like_3, Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins. The family includes many uncharacterized bacterial hypothetical proteins that show high sequence similarity to insect chitin deacetylase-like proteins. Chitin deacetylases (CDAs, EC 3.5.1.41) are secreted metalloproteins belonging to a family of extracellular chitin-modifying enzymes that catalyze the N-deacetylation of chitin, a beta-1,4-linked N-acetylglucosamine polymer, to form chitosan, a polymer of beta-(1,4)-linked d-glucosamine residues.	1.5014e-111
NZ_CP016793.1|WP_063798906.1|2023975_2024098_+|pyrroloquinoline-quinone-precursor-peptide-PqqA	gnl|CDD|369666	pfam08042, PqqA, PqqA family. This family consists of proteins belonging to the coenzyme Pyrroloquinoline quinone A (pqqA) family. PQQ is the non-covalently bounded prosthetic group of many quinoproteins catalyzing reactions in the periplasm of Gram-negative bacteria. PQQ is formed by the fusion of glutamate and tyrosine and synthesis of PQQ require the proteins encoded by the pqqABCDEF operon but details of the biosynthetic pathway are unclear.	0.001509
NZ_CP016793.1|WP_065920948.1|2005707_2006508_+|nucleotidyltransferase-domain-containing-protein	gnl|CDD|313370	pfam10127, Nuc-transf, Predicted nucleotidyltransferase. Members of this family of bacterial proteins catalyze the transfer of nucleotide residues from nucleoside diphosphates or triphosphates into dimer or polymer forms.	2.00664e-55
NZ_CP016793.1|WP_065914754.1|2006770_2007640_-|mycothiol-conjugate-amidase-Mca	gnl|CDD|132487	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca. Mycobacterium tuberculosis, Corynebacterium glutamicum, and related species use the thiol mycothiol in place of glutathione. This enzyme, homologous to the (dispensible) MshB enzyme of mycothiol biosynthesis, is described as an amidase that acts on conjugates to mycothiol. It is a detoxification enzyme. [Cellular processes, Detoxification].	0
NZ_CP016793.1|WP_065914762.1|2016004_2017225_+|acetyl-CoA-C-acetyltransferase	gnl|CDD|181146	PRK07851, PRK07851, acetyl-CoA C-acetyltransferase.	0
NZ_CP016793.1|WP_065914758.1|2011092_2012238_-|cystathionine-gamma-synthase	gnl|CDD|236104	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional.	0
NZ_CP016793.1|WP_065914760.1|2013565_2014933_-|cystathionine-beta-synthase	gnl|CDD|273464	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase. Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family].	0
NZ_CP016793.1|WP_065914764.1|2017599_2017986_-|GNAT-family-N-acetyltransferase	gnl|CDD|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.19917e-13
NZ_CP016793.1|WP_083267898.1|2019216_2020605_+|hypothetical-protein	gnl|CDD|227268	COG4932, COG4932, Predicted outer membrane protein [Cell envelope biogenesis, outer membrane].	6.21812e-05
NZ_CP016793.1|WP_065914767.1|2022634_2023672_-|PQQ-dependent-sugar-dehydrogenase	gnl|CDD|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	3.14273e-72
NZ_CP016793.1|WP_065920951.1|2009477_2010659_+|4-hydroxyphenylpyruvate-dioxygenase	gnl|CDD|273528	TIGR01263, 4-hydroxyphenylpyruvate_dioxygenase, 4-hydroxyphenylpyruvate dioxygenase. This protein oxidizes 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic (see . In some bacterial species, this enzyme has been studied as a hemolysin. [Energy metabolism, Amino acids and amines].	2.0467e-161
NZ_CP016793.1|WP_053739481.1|2008346_2008841_+|transcription-elongation-factor-GreA	gnl|CDD|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	1.6552e-55
NZ_CP016793.1|WP_065914765.1|2018081_2018885_-|Bax-inhibitor-1/YccA-family-protein	gnl|CDD|378959	pfam12811, BaxI_1, Bax inhibitor 1 like. The Bax-inhibitor-1 region of the receptor molecules is conserved from bacteria to humans.	1.14658e-87
NZ_CP016793.1|WP_083268756.1|2020751_2021309_+|class-F-sortase	gnl|CDD|320678	cd05829, Sortase_F, Sortase domain found in the class F family of sortases. Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.	2.51636e-38

Protein sequences

>NZ_CP016793.1|WP_065914758.1|2011092_2012238_-|cystathionine-gamma-synthase
MSTPYGFATRAIHAGQDPDPTTGAVNVPIYATSTYAQDGVGGLRQGFEYSRTGNPTRRALETALASLERGRYGRAFSSGMGATDTALRAFLKPGDHIVIPNDAYGGTFRLIDKVFSQWGITHSPAPVSDVDAIRAAITPATKLVWIETPTNPLLNVGDIAAIASVTHSAGAKLVVDNTFASPALQTPLELGADVVLHSTTKYVGGHSDVVGGALVTSDEETDAAFGFLQNGAGAVPGPFDAYLTLRGLKTLELRMEKHSDNAELVAEALLRHPRVKKVIYPGLEAHPGHAVAAKQMRRFGGMVSFLVEGGEEAALAVCARTKLFTLAESLGGVESLIEHPGKMTHASTAGSMLEVPADLVRVSVGIESGDDLVADLLEALG
>NZ_CP016793.1|WP_065914757.1|2010713_2010962_+|hypothetical-protein
MALVRRVAAVIPLVGAVTTAAALTGAAFLTVAHAGCDEAGRFVRTGESIEFVGGCVNGADLPAAPTAEVADNVDRFGGSKKP
>NZ_CP016793.1|WP_065920951.1|2009477_2010659_+|4-hydroxyphenylpyruvate-dioxygenase
MTQQLDDVSYDQLRQLVGLVDYDATKDPFPVRAMDAVVFVAGNATQTAWLYQVAFGMELVAYAGPETGQRTHKSFVLKSGSARFVIHGGVQPGSPLLDHHRKHGDGVVDLALEVGNVDQCIEHARQQGATVLEEPHDVSDEHGTVRLAAIATYGETRHTLVDRSKYTGPYLPGYVARTSTVKRPEGAPKRLFQAVDHCVGNVELGKMDYWVEWYNRVMGFVNMAEFIGDDIATDYSALMSKVVSNGNHRVKFPLNEPAIAKKKSQIDEYLEFYEGAGVQHIALATNDIIKTVTAMRDAGVEFLETPDSYYDDPELRARIGEVRVPIEVLKEHRILVDRDEDGYLLQIFTKPIGDRPTVFYELIERHGSLGFGKGNFKALFEAIEREQERRGNL
>NZ_CP016793.1|WP_065914756.1|2008884_2009403_-|Lrp/AsnC-family-transcriptional-regulator
MPEDQQSEHSDQTVDELDARLLLLLTDEPRLGVLECSRRLGVARGTVQARLDRLTDRGVLTGFPPALDLGAMGYGLTAFATVEIAQGRRQEVCEGLAAISEVCEVHATTGQGDLFVRMVARSNADLQRVVDHIVDVPHVRRLSTSIALSTPVPPRVRPLLERVKKTEGRPPR
>NZ_CP016793.1|WP_053739481.1|2008346_2008841_+|transcription-elongation-factor-GreA
MTVSDTQVTWLTQEAYDRLKAELDELIAYRPVMAAEINARREEGDLRENGGYHAAREEQGKQEARIRQLHELLQAAKVGEAPTTKGVAAPGTVLTIRYEGDDETETFLLATREEGAHGEMEVYSPSSPLGKALNGSKDGETVEYELPNGKLQKVTLISAVPYAG
>NZ_CP016793.1|WP_065914755.1|2007736_2008159_+|DUF4307-domain-containing-protein
MAQRALPEGRYGRSTRKKLPWWARVALLAVAVGVGAVVAIVGYRNLGTKPIEAEQTAFQILDSERVEVTFQVSRDQPERPAVCIIRARSKDGDEAGRREVLVPPGNSTVVETTVVRGSKPPVTGEVFGCSYQVPAYLSTS
>NZ_CP016793.1|WP_065914754.1|2006770_2007640_-|mycothiol-conjugate-amidase-Mca
MADKLRLMAVHAHPDDESSKGAATMARYIAEGHDVMVVTCTDGGAGSILNPAMDKPDVLENIIEVRREEMANAAKILGIQHRWLGFKDSGLPEGDPLPPLPEGCFALVPLEESVPSLVEAIRDFRPHVIVTYDENGGYPHPDHIRTHEISMAAIDAAADPSFDPSLGKPWETQKVYYSHGFSRAKLMAFHEALEARGLESPYTEWLANWDANRPDVMDRVTTRVECSKYFDVRDEALKAHATQIDPTSRWFAIPMDIQVEVWPTEEYELVRSLVDSTLPEDDLFAGVKV
>NZ_CP016793.1|WP_083267897.1|2006504_2006768_-|hypothetical-protein
MNPWTDTVAIVAVQQPSNTNDDKGGQGEDFGKSSPVGLVLLVLFFIAVFFLVRSMNKHLKKLPASFDEPAESAAGTSAPAESPKKKD
>NZ_CP016793.1|WP_065920948.1|2005707_2006508_+|nucleotidyltransferase-domain-containing-protein
MAGVGAQEVVVSLEVPDLSEVVAEQSHGLLFATVSGAHLYGFPSRDSDVDLRGVHVLPLTEVVGLKHGPETKERMWVRDGVEIDLVTHDVQKFCRLLTRPNGYVLEQLLSPLVVHTTDGHRQLVELATGCLTSRHAHHYGGFATTQWRLFEKTGEIKPLLYTFRALLTGVHLMRSGEVVAHLPTLLEKLDGPEYLGPLVEAKVLGEHRALAGVDARPAPERLEADLAHWHEELQRARESSELPHEPPAFDEVHDFVIRTRLGQVGG
>NZ_CP016793.1|WP_083268755.1|2005075_2005741_+|nucleotidyltransferase-domain-containing-protein
MRLRRAGPRVGTGGPTTVILEAVVGSHAYGLATPSSDVDRRGVYVAPTEAFWRFEKPPTSVEGPSDEQLSWEVEHFCRLGLKSNPTVLETLVSPLVEVCTPLGEELRALLPAFLSRYAVRAYTRATEMQLSRAGRNLKPKQLMHVVRLRLVGLHLMRTGVLDITADRSLLAIRSGEMPWNEAVAWAHRLGEELNNADGPLPEDPDRARVEDWLVSVRRRSL
>NZ_CP016793.1|WP_065914760.1|2013565_2014933_-|cystathionine-beta-synthase
MEYVEHVVDLVGNTPLVKLNSLTSGIKATVLAKVEYLNPGGSVKDRIALRMVEAAEKSGELQPGGTIVEPTSGNTGVGLALVAQRKGYKCVFVCPDKVSEDKRNVLKAYGAEVVVCPTAVAPEHPDSYYNVSDRLVREIPGAWKPNQYANPENPASHYHQTGPEIWRQTDGKITHFVAGVGTGGTISGTGRYLKEVSDGAVRIIGADPEGSVYSGGTGRPYLVEGVGEDFWPETYDKTVCDQIVEVSDADSFDVTRRLAREEGLLVGGSCGMAAAALRVARDLPEDAVVVVLLPDGGRGYLSKVFNDRWMASYGFLPPDSTGATVGDVLRRKGGQLPDLVHAHPNETVGDAVAILREFGVSQMPVVNAEPPVMAAEVSGAVNERDLLDALFTGKAQLSDRLDKHMGVPLPTLGAGEPVSVAMAAMAHADGALVLEDGKPAGVVTRQDILGFLAGR
>NZ_CP016793.1|WP_065914762.1|2016004_2017225_+|acetyl-CoA-C-acetyltransferase
MPEAVIVSAARSPIGRAGKGSLKDVRPDDLAAQMVKAALDKVPQLDPAQIDDLMLGCGLPGGEQGFNMARVVSVLLGHDTLPGTTVTRYCASSLQTTRMALHAIKAGEGDVFISAGVETVSRFAKGSSDSWPDTHNPLFADAEARTASVAASGASTWDDPRVSGALPDIYVPMGQTAENLALLKGVSRQEMDEFGVRSQNLAEKAIADGFWAREITPVTLPDGTVVSTDDGPRAGVTYDAVSQLKPVFRPDGRINAGNCCPLNDGAAALVVMSDTKARELGITPLARIVSTGVSGLSPEIMGLGPVEASKRALALAGLSISDIDLVEINEAFAAQVIPSYQDLGIDLDRLNVNGGAIAVGHPFGMTGARITTTLINSLQFHDKQFGLETMCVGGGQGMAMVLERLS
>NZ_CP016793.1|WP_065914763.1|2017393_2017603_+|hypothetical-protein
MPYVWWQSEYDLQCHAFSLDQANGTRTYYEAVCEHSVPDERVSRAQAGALCTDCLIKIGTELPDVRWRA
>NZ_CP016793.1|WP_065914764.1|2017599_2017986_-|GNAT-family-N-acetyltransferase
MKPPAVDDYLRLREESGLSARTRAEVENGIDGAWAAAHVIHVESGETVGMGRVISDGGWYFHIIDMAVLPGHQRKGIGDAVMTALLRLIHEHAPTASVSLLADPPGRRLYERHGFVDTAPASVGMRRA
>NZ_CP016793.1|WP_065914765.1|2018081_2018885_-|Bax-inhibitor-1/YccA-family-protein
MRSSSNPAFRNLPTGGGYGGYAGFGQPEAGYQQAPPPLTSERPMTIDDVVTKTGITLAVVAVTAVITYLMQAWVLLFPAAIIGLVLALVITFKRNPSPPLVLAYAAVEGVFLGAFSGIIGRLIDGWTGNPGQGVVVIGQAIIGTIGVFAGMLIVYKTGAIRVTPKFTKWITGAIIGVAILMLFNLIMSFFTTGGLGLRSGGTLAIIFSLVCIGLAALSFLIDFDAADQAIRAGVPAKFAWQIAFGLTVTLVWLYTEILRLLSYFNSD
>NZ_CP016793.1|WP_083267898.1|2019216_2020605_+|hypothetical-protein
MGWKRLAAVAAVSGLALLTVPAPATAVGVKGIGHNATQVQPNATPGSEWHGSYVWQDKHVWCVQYALPAPDSAVGYKPGDELLTKAGKKLDPAVAANISYLLLRYSTTKSPEEAAALAHLLHSWTAAPDGPVRFDTPDPKYLAYNAEWYAARLPQSVMDTVARLRADAEANRGPWTLSAAAPTDPLVIGTESTWTVALLKQNDKGVPNAPISFTLTDAKLTDGSASGTVTTDANGAPVALKVIPTGPKPAIAVTADSPADKPVVHQPIQTENMQRIVTTGGEKELTAAANAPARTAPGAVKITKIDSETKKAIAGVALRVTAKDQTSPALKQDDSPLVGTDGKPLVLQTGADGTVEVPGLRTPQEICLVEVAAPKGYEEFFDPKAPPASCGSVAPGSTLALELVNKPNTPVVPSTIPAGTEGSTPVATASFETQLRPGLMLAVGGLVLLGAALAGLLVWRRQ
>NZ_CP016793.1|WP_083268756.1|2020751_2021309_+|class-F-sortase
MSTGRGADLTGLIGGANTNNAKPVEPTQQQPQQQQPAPPKAGPGSVRLPSGGSATLVRREVEDGVLPVPDGIGEATWWGTELAAAEGATVLAGHVDWKGAKGPFAELWQAQNGREVVIADSSGKEFRFRIKQIETVRKEELPARAVEFFGPRGPHRLVLVTCGGTWIGGQQGYEANRVVIAEPVA
>NZ_CP016793.1|WP_065914766.1|2021361_2022528_+|polysaccharide-deacetylase
MKRWGWLTTGVALALALVLVMTLSPHSDQEQQAETGPLPMAPRLPAPKNTGPTPRVPDPTPEQLRKQPWMHRLGQGEKPPQFVLFSFDGAVSKQHWDKVLPLTRQTGAHVTGLLSGVYLLADQDKTQYQPPAGLKRGRSDIDFGGSRQDIAARIEYLNQVVDEGHEIGTHYNGHFCSGGSQPSVDKWDNKAWNQELDQFRLIVDKARAAGFKLAADAVRGGRTPCLEGNWDEAFPAMAAHGLVYDTSQVALGVQWPYVHNGLYEFPMPEVRVPALGKQVVMMDFNLWYSLNGAKDEPARAGEFTQIVVDTYRSVYRAALNGNRAPLVIGNHFNEWNGSAFSTAMEQFLGEVCGKPETVCATYTEVIQWMQLQDPAVLDQLRKMPAARN
>NZ_CP016793.1|WP_065914767.1|2022634_2023672_-|PQQ-dependent-sugar-dehydrogenase
MRARRIAAAAACTAVAASLCAIPASAQEDPSALAERTLATRLDIPWDIEFLPDGSGIFTERDTRKIKKLSGTTVTELDTVEQAQTTGGEGGLLGLAVSPSFATDNSVYIYYSTATDNRVAKLALGGTPQPIVTGIPKNRYHNGGGLEFGPDGFLWATTGDGQNTGTAQNWNSLGGKVLRFDTAGRPAAGNPRAGSVVYSIGHRNVQGITWAGNTAYATEFGNNTTDEINRIEAGKNYGWPTCEGNCNTAGMTNPVRTWPNSQAGPSGIAYHKNALYVGAVTGRRIWKIPVNGTTLGTPQALFTGTYGRVRSIAPAPDGTLWLGTSNQDANGQPGSTDDRIISTDS
>NZ_CP016793.1|WP_063798906.1|2023975_2024098_+|pyrroloquinoline-quinone-precursor-peptide-PqqA
MNVAATATEQKLPEVKREWVKPDFRDFETPMEVTAYAARS

Crispr_ID: NZ_CP016793_7

• CRISPR_ID: NZ_CP016793_7
• CRISPR_location: 2870371-2870655
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NZ_CP016793_7

Consensus_repeat	Method
TACGGCCAGCAGCAGGGCTACGGCCAGCAGGGC	CRT

spacers of NZ_CP016793_7

>7.1|2870404|51|NZ_CP016793|CRT
GGCTACGACCAGGGCTACGGCCAACAGCAGCAAGGCGGTTACGACCAGGGC
>7.2|2870488|51|NZ_CP016793|CRT
CAGCAGGGCTATGACCAGGGTTACGGCCAGCAGGGTTACGACCAGGGTTAC
>7.3|2870572|51|NZ_CP016793|CRT
TACGACCAGGGTTACGGCGGCGGCCAGCAGGGCGGCGGCTACGACCAGGGT

CRISPR arrays and Neighbor proteins around NZ_CP016793_7

CRISPR arrays

The CRISPR arrays of NZ_CP016793_7

>merge|NZ_CP016793|7|2870371-2870655|CRT
TACGGCCAGCAGCAGGGCTACGGCCAGCAGCAGGGCTACGACCAGGGCTACGGCCAACAGCAGCAAGGCGGTTACGACCAGGGCTACGGCCAGCAGGGCGGCGGCTACGGCGGCGGCCAGCAGGGCTATGACCAGGGTTACGGCCAGCAGGGTTACGACCAGGGTTACGGCGGCCAGCAGCAGGGCTACGGCCAGCAGGGCTACGACCAGGGTTACGGCGGCGGCCAGCAGGGCGGCGGCTACGACCAGGGTTACGGCCAGCAGCAGGGCTACGGCCAGCAGGGC

>NZ_CP016793|7|1|2870371-2870655|CRT
TACGGCCAGCAGCAGGGCTACGGCCAGCAGCAG	GGCTACGACCAGGGCTACGGCCAACAGCAGCAAGGCGGTTACGACCAGGGC
TACGGCCAGCAGGGCGGCGGCTACGGCGGCGGC	CAGCAGGGCTATGACCAGGGTTACGGCCAGCAGGGTTACGACCAGGGTTAC
GGCGGCCAGCAGCAGGGCTACGGCCAGCAGGGC	TACGACCAGGGTTACGGCGGCGGCCAGCAGGGCGGCGGCTACGACCAGGGT
TACGGCCAGCAGCAGGGCTACGGCCAGCAGGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_065915479.1|2877529_2879533_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP016793.1|WP_065915481.1|2881742_2882204_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_083267955.1|2863665_2864292_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NZ_CP016793.1|WP_083268800.1|2860493_2861654_-|MFS-transporter	unknown	unknown	gnl|CDD|340883
NZ_CP016793.1|WP_065915463.1|2859714_2860494_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|212491
NZ_CP016793.1|WP_065915477.1|2874469_2875945_+|penicillin-binding-protein-2	unknown	unknown	gnl|CDD|223839
NZ_CP016793.1|WP_154697312.1|2865773_2867066_+|FAD-binding-protein	unknown	unknown	gnl|CDD|130740
NZ_CP016793.1|WP_065915471.1|2867822_2868440_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065915482.1|2882200_2882662_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065915470.1|2867151_2867808_-|NAD(P)H-binding-protein	unknown	unknown	gnl|CDD|187554
NZ_CP016793.1|WP_065915474.1|2871129_2871591_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|224630
NZ_CP016793.1|WP_065915466.1|2863024_2863669_+|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|380058
NZ_CP016793.1|WP_065915465.1|2861694_2862942_-|beta-glucosidase	unknown	unknown	gnl|CDD|274539
NZ_CP016793.1|WP_083268801.1|2873105_2874473_+|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl|CDD|279444
NZ_CP016793.1|WP_065915468.1|2864520_2865702_-|amino-acid-deaminase/aldolase	unknown	unknown	gnl|CDD|143488
NZ_CP016793.1|WP_154697313.1|2868755_2869568_-|hypothetical-protein	unknown	unknown	gnl|CDD|176191
NZ_CP016793.1|WP_065915480.1|2879593_2880235_-|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl|CDD|181107
NZ_CP016793.1|WP_170067916.1|2882648_2882804_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065921063.1|2880339_2881656_+|pyridine-nucleotide-disulfide-oxidoreductase	unknown	unknown	gnl|CDD|215457
NZ_CP016793.1|WP_065915475.1|2871587_2872997_+|serine/threonine-protein-phosphatase	unknown	unknown	gnl|CDD|223704

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065915479.1|2877529_2879533_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.7754e-129
NZ_CP016793.1|WP_083267955.1|2863665_2864292_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	0.00844101
NZ_CP016793.1|WP_083268800.1|2860493_2861654_-|MFS-transporter	gnl|CDD|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.00695e-19
NZ_CP016793.1|WP_065915463.1|2859714_2860494_-|SDR-family-oxidoreductase	gnl|CDD|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	7.58699e-48
NZ_CP016793.1|WP_154697312.1|2865773_2867066_+|FAD-binding-protein	gnl|CDD|130740	TIGR01679, bact_FAD_ox, FAD-linked oxidoreductase. This model represents a family of bacterial oxidoreductases with covalently linked FAD, closely related to two different eukaryotic oxidases, L-gulonolactone oxidase (EC 1.1.3.8) from rat and D-arabinono-1,4-lactone oxidase (EC 1.1.3.37) from Saccharomyces cerevisiae.	2.36369e-102
NZ_CP016793.1|WP_065915477.1|2874469_2875945_+|penicillin-binding-protein-2	gnl|CDD|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	4.95025e-95
NZ_CP016793.1|WP_065915470.1|2867151_2867808_-|NAD(P)H-binding-protein	gnl|CDD|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.22891e-49
NZ_CP016793.1|WP_065915474.1|2871129_2871591_+|FHA-domain-containing-protein	gnl|CDD|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	6.32025e-23
NZ_CP016793.1|WP_065915466.1|2863024_2863669_+|TetR-family-transcriptional-regulator	gnl|CDD|380058	pfam17928, TetR_C_22, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the TetR Transcriptional Repressor present in sco1712 proteins from Streptomyces coelicolo which act as a regulator of antibiotic production.	1.09847e-20
NZ_CP016793.1|WP_065915465.1|2861694_2862942_-|beta-glucosidase	gnl|CDD|274539	TIGR03356, BGL, beta-galactosidase.	0
NZ_CP016793.1|WP_083268801.1|2873105_2874473_+|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl|CDD|279444	pfam01098, FTSW_RODA_SPOVE, Cell cycle protein. This entry includes the following members; FtsW, RodA, SpoVE.	9.18169e-82
NZ_CP016793.1|WP_065915468.1|2864520_2865702_-|amino-acid-deaminase/aldolase	gnl|CDD|143488	cd06813, PLPDE_III_DSD_D-TA_like_2, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2. This subfamily is composed of uncharacterized bacterial proteins with similarity to eukaryotic D-serine dehydratases (DSD) and D-threonine aldolases (D-TA). DSD catalyzes the dehydration of D-serine to aminoacrylate, which is rapidly hydrolyzed to pyruvate and ammonia. D-TA reversibly catalyzes the aldol cleavage of D-threonine into glycine and acetaldehyde, and the synthesis of D-threonine from glycine and acetaldehyde. DSD and D-TA are fold type III PLP-dependent enzymes, similar to bacterial alanine racemase (AR), which contains an N-terminal PLP-binding TIM barrel domain and a C-terminal beta-sandwich domain. AR exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Based on their similarity to AR, it is possible members of this family also form dimers in solution.	0
NZ_CP016793.1|WP_154697313.1|2868755_2869568_-|hypothetical-protein	gnl|CDD|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	4.63732e-53
NZ_CP016793.1|WP_065915480.1|2879593_2880235_-|aminodeoxychorismate/anthranilate-synthase-component-II	gnl|CDD|181107	PRK07765, PRK07765, aminodeoxychorismate/anthranilate synthase component II.	1.26122e-132
NZ_CP016793.1|WP_065921063.1|2880339_2881656_+|pyridine-nucleotide-disulfide-oxidoreductase	gnl|CDD|215457	PLN02852, PLN02852, ferredoxin-NADP+ reductase.	5.86843e-136
NZ_CP016793.1|WP_065915475.1|2871587_2872997_+|serine/threonine-protein-phosphatase	gnl|CDD|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	2.14472e-78

Protein sequences

>NZ_CP016793.1|WP_154697313.1|2868755_2869568_-|hypothetical-protein
MSVTRSGVGMWGIAAADFGAELQLVELPEPQAGPDELKVRMFAASVNPFDRKVVNGMLRESAEHRFPLVPGTDGAGEVVGSGERIFGTFFHRPVGGGTYAEYVTVPAQNVLAPLPEDLDPAVAAALPTAGMTALQLVESLGDAKSVVVIGPNGGVGSFAVQIARAAGKDVIPVGRGDSLVEADALIDLVSTDRSSFEANARYAPLAFNTNYVSSDNAQNFGMKGSREMLVRLASMVQAGDLSVPIARRVPLRDAADVFAGHGPGKTVIIM
>NZ_CP016793.1|WP_065915471.1|2867822_2868440_-|hypothetical-protein
MSSTPARIAAPGSAQGLSTTPVPVPELPASVEELAAAAAIRLGWHGVVLPEMVLMGRKVVVVAELLADAHAERVCVGAGPEADKTTVSTWVWPEMEGRVPPAAVRIVGVLAVARHWRTALASAVPFSRYGNAAVVLPDSVAFTNDYLTNCLPRVRRYGVSVLLADDEKDLSVDVSGRNECVPVEDTAITRWVNELVYEQVLATAS
>NZ_CP016793.1|WP_065915470.1|2867151_2867808_-|NAD(P)H-binding-protein
MRVVIAGGHGQIALLLEQLLATRGDAATALVRNPDHFADVQEAGAVPVLCDLESATVDSVADYLNGADAAVFAAGAGAGSGAARKDTVDFGAAALFATAAAEAGVRRFLQVSTVGIESADSPSVNPEFAVYLKAKKAAEDDLKPRDLDWTILRPGPLTNDAPTGLVTLAAPVLPRSEVTRADVAAVLAELLTAPQTIGKTLELTNGPTPIPDAVRAIL
>NZ_CP016793.1|WP_154697312.1|2865773_2867066_+|FAD-binding-protein
MEVRVWTNWARTASCAPTRVVHPASTDEIAATVVSGGRVRARGSGHSFNDIAVAPEIALDLDRWTGIVRADAESGLVTVRSGTPLHVLNADLHRLGLAMPNLGDIDAQTVAGAVSTSTHGTGAKLGVLATAIAALELVLADGSVVTCSRSERPDLFNAARVGLGALGVISTITLQCVPSFVLRASESPGRLDAVLEQFDDLCAVEDHVEFHWFTHSDRVILKRNNRISEPARPLSRARQVWEYEVMENAAFGAVCKVAKTFPRYTRKLNELCGSLISERTYSDYSHNVFVTPRRVRFVETEFSIPRETLMDVIGELRAVATKLGDRDALIVPCEVRVAQADDIWLSTASGRDTAYISMHQALGMPYKAFFDAYASIAASVGGRPHWGKMHDLTSAELRPLYPHFDDFLRVRDEVDPTRTFTNAYLDRVLG
>NZ_CP016793.1|WP_065915468.1|2864520_2865702_-|amino-acid-deaminase/aldolase
MRRTRLDTATKDLDPPFAIVDLDAFDHNAADLARRAAGHPIRVASKSIRVRDLVSRALDRPGYAGVMCYSLAEALWLSEQNVSEDLLVAYPTADRAALQKLAANETARQRVTIMVDSVEHLDFVDAAIGPHSDIRVCLELDVSWRPLPGVHIGPRRSPVHTPAQAASLAAKIARRSGFTLVGVMAYEGQIAGLGDNPPGQPLRALAIRAIQAKSGPELIGRRTAVVTAVRQVAELEFVNGGGTGSLELTGTDPSVTELAAGSGLFGPTLFDGYQAFKPEPAALFALPVVRKPAKRVATLFAGGYIASGTPTPDRQPSPYLPEGLKTLGLEGAGEVQTPVTGKAAEQLAIGDRVWMRHAKAGELFERFDEVHLVHGDRIERTVPTYRGERRNFG
>NZ_CP016793.1|WP_083267955.1|2863665_2864292_-|helix-turn-helix-transcriptional-regulator
MSRWTRCPSEVVALGRWLSDERRAVGLTNDRLGARIGYHGTTVSRACNGKAVPSWALVSAIVVACHGDVGLARRLWEDAVQAQRVRRNQRIRREPIGRIDSFDGLSAGLRQMWLDTGLSQRAIVHADESGRLRRSSLGAVLRGERRPHKELTAALTRACGGDEQTVAVWVQVWEQLDADHQRARYSALLAARERRRHYFRSRTAFRRP
>NZ_CP016793.1|WP_065915466.1|2863024_2863669_+|TetR-family-transcriptional-regulator
MDVPELLGVAVTSTTPLRRQPVQQRSAKRVERMLEACATLIDEVGYDGVTTTLIAERAGVAVGSLYQFFPDKRAVVQALTLRNVDRFSSGITERLEQATLEHWWDAVDTVFDVYVTMHREIPAFGKLHFGDVVDMRLLDDRRDNNAVISDKISELISGKFGIPMSEVQLPIAIAVEAADAVLKMAFRNNATGDQAILVEAKALVRGYLSSRLPA
>NZ_CP016793.1|WP_065915465.1|2861694_2862942_-|beta-glucosidase
MSDFLWGVSTSAFQIEGAFDAGGRGPSVWDDFAPVHDNDNARVACDHYYRWREDVALMTQLGVNAYRFSIAWPRVQPSGKGPVNAEGLDFYDRLVDALIDVGIAPVVTLHHWDTPLELEAEGGWLHRDIADRFADYTALVADRLADRVHMWIPINEPAMVTLQGYAIGEHAPGKTLLFDALPTAHHLNLAHGRAVEVLRGYNARAVGTANNHTPAWPATEADQPAADAYSDIHNWLYADPVLTGRYPNSVAELLPVRDGDLATIHQPLDFYGVNYYNPTRLKLPSEGNPLPFELVDIHEFPRTGFGWPVVPSGLSEMIGTLRERHPDLPPVHVTESGCSFPHEVEDAARIAYLDGHLKAALAAGVEGYFVWSLLDNFEWEAGYSQRFGLVHVDYETQRRTPRDSFHWYRRVISGE
>NZ_CP016793.1|WP_083268800.1|2860493_2861654_-|MFS-transporter
MAWLFAANLGLWLAIYAPIQVLLPQQAALLDGADKEFVFGLVTGVGAAVSLLVVPLIGFLSDRTTSRFGRRHPWTVIGAVVGAAGLGVLAEASSVAVMTIGWCLVQAGIGGMLAALTAVVPDRVPVAQRAQVGGLIGISQMLGTVLGAVVVTLLVSGLQAGYLACAVIVVVGAVFFVLRTPDTQLVTKPVRPTFWISPRDHPDFAWAWGGHLLINLGNAFGTLYLLYFLGDVVRHESPEDGLLVLMALYGVALAAGAVLFGARSDRSGRRKPYVYLAAFVMALAALLLVVWPTWIASLIAAPLLGVGFGIYWAVAIALLTQVLPAASDRAKDLGVLNVANALPQVIAPLLTAVILANLGGYRGLFAASALATALAAVLMSRVRSVV
>NZ_CP016793.1|WP_065915463.1|2859714_2860494_-|SDR-family-oxidoreductase
MQLSGKRVLVTGASQGIGAEAAFRFAAHGAHVDLVARSAELLDLQVKRITEFGGSAKAHVADLADAAQIRTLAEAVDTPDVLVNNAGVGRWLFLDECTQDDLTTMTAVPFMAAMLLTREFLGAMRSRGSGWIVTVNSPVSRLPIPGAVGYQSARWALRGLTASLRLDLRGTGVGVSEVVPGKVSSEYFANNPGAEERIPAIARLIPTVTPERVAVAIVDAVRKERAEHLFPWQLKAFELSGRLLPGLTSYLTWKTGTRR
>NZ_CP016793.1|WP_065915474.1|2871129_2871591_+|FHA-domain-containing-protein
MQELVMQLTRAGFLVLLWLFVLAALRVVRSDLYAASGLRASGLPGFRRSDKSARGSKAPRTLVVTHGALTGTRISLDGRPILIGRADDSTLVLDDDFASTRHARLSMRGTDWYVEDLGSTNGTYLDRAKVTAPLRVPLGTPIRIGKTVIELRS
>NZ_CP016793.1|WP_065915475.1|2871587_2872997_+|serine/threonine-protein-phosphatase
MTLVLRYAARSDRGLVRSNNQDSVYAGPRLLAVADGMGGHAAGEVASKVVIASLAHVDDDEPGDDLLGKLRDAVAAGNGAISELVASDPDLEGMGTTLTAVLFAGNRLGLVHIGDSRAYLLREGSFAQITHDDTFVQSLIDEGRITPDEAATHPQRSLLLRALTGHDFEPSLTVREARSGDRFLLCSDGLSGVVSLETLDEAIRIPDPQACADRMIELALKGGGPDNVTVIVADVEDVDFGDDYPIVGGAAGDGSEEHNTPPDSAASRASALTQQRPPMPQRMEAPPPPPQDPKRKKRNTLKAFALIFLLLVVVGAAGVGGKLWLNTQFYVGATEDGQVAIFRGLNGTVLGFKLSSKVEDSCPPGSSGCTPIAVNDLQEAGRKTITDGIRSDNGIEGARAAVRMLRTAHMLPLCKDTSASSSPTSPTTPTPPANGSPSPTTPPPSGSETTEPSLTSSAQKPGVECREGP
>NZ_CP016793.1|WP_083268801.1|2873105_2874473_+|FtsW/RodA/SpoVE-family-cell-cycle-protein
MLSFAAGLVTLALILVELNQERSLSLRILWLGLAYLGLFACAHLAVRRWAPYADPVILPCVAFLNGLGLVVIHRIDLAMEGTVFDDGSTWDPMAFKQVIWTAIGLLLFAATLKFLTDHRTLARFGYTFGLAGLVALLLPGVLPGFIAPTINGAKIWLRIGPFSIQPGEFAKILLMVFFAAFLVSKRDLFTTAGRRFLGMDLPRARDLGPLFAAWGVAVAVMILQKDLGSSLLFFGIVLVLLYVATERAAWVVLGLGLFAGGAVIAWKLFTHVQQRVANWSDPMATYNEDGGGYQIAQSLFGLATGGIGGAGLGAGRPEMIPESNTDFITAVIGEELGFVGFAALLLVYMVVAMRGLRSAISVRDSFGKLLGGGLAFAMCFQVFIVVGGVTKLIPMTGITAPFLSKGGSSLLANYVLIALLLRISAAARAPQRAPKPKPQQPAIADQHTVMVERPK
>NZ_CP016793.1|WP_065915477.1|2874469_2875945_+|penicillin-binding-protein-2
MNTPLRRVGFAMMVMILLLLGNATWVQVINADEWRKNPNNRRVLLDEYGRKRGLIMAADGMVIADVKETTDRLRYLRTYAAPQAYAQVTGYLSVTYGTSGIERAENDLLNGSDDRLFTRRVSALITGRDPVGGNVQLTLVPKVQQVAYEQLAAKGFRGSVVAIKPETGEILAMVSTPSYDPNLLASHDSAQQQSAWKQLIAEGNGNPLINRATGGLYPPGSTYKVVVAAAALADGKTKESQYTAAGSATPTGTTVPLPNFNGQPCGGGQTASMELALAKSCNTAFGEMAEQIGKAKLKTQSDKFGFNDDNLQIPLNVETSTLGEIPDNPALWQTGIGQRDVRVTPLQNAMVAATIANGGERMQPYLVSKILGPDLKAIDETDPDEINTAMSSANAAALRDMMVQSEINTGGEGRLANVQVASKTGTAEVGGSRQQTEAPHAWYIAFAPAQKPEIAIAVIVENGGDRGLGATGGKVAAPIGRAVMNTYLAGR
>NZ_CP016793.1|WP_065915479.1|2877529_2879533_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MSTPRLLSNRYELGETLGYGGMSEVHKGRDVRLGRDVAIKVLRADLARDAQFQERFRREAQNSAALNHPAIVAVYDTGETQTEYGPLPYIVMEFVDGRTLRDIVKTQGPLSGKRAMEVMADVSAALDFSHRHGIVHRDVKPANVMITKSGAVKVMDFGIARALHDGQAAVTQTAAVIGTAQYLSPEQARGESVDARSDVYAAGCVLFELLTGEPPFTGDSPVAVAYQHVREDPKAPSSLNPKVSPQLDAIVLKAMAKGPANRYQSAAEMRADLVRVLSGQRPSAPAVMTAEDRTAVMNEQARAPRTQTINGGGRHRPAALKSEPDDDYDPVADEEDDRRAKRKKTIMIALVVVLCIAVLGLAAWITTSLMNSSGSDDPQKVSVPAVVGMEPLLANDKLTQAGLKPKQELVPCEPGPNGAAAACTAEQIGKVLGTNPTEGTTLVKGTEVLVRVGSPPGEGTVPDLTGKSPTEAQQILDKDPNGFKVQQSDQLIETDEAAKVGKVVQQNPSVGLKLKKGGTITISLGKAPDKQNVPGVVGDDVNDARQTLEGSGFKVNVQPVDSAKPLNEVLKQDPAPNTKAAKDTTVTLQVSKGNLFEMPDLTGLSAKDAEARLRQLGWNGNFNEDDQQVSNPQQDKKVIGQSVQKGQAITKGQAITVNVGKFGIITS
>NZ_CP016793.1|WP_065915480.1|2879593_2880235_-|aminodeoxychorismate/anthranilate-synthase-component-II
MRVLVVDNYDSFVYNLVQYLAQLGAECVVRRNDEVDLNEIDGVDGVLVSPGPGTPERAGSSIDVIKKCADTGKPVFGVCLGHQAIGVVWGGTVDRAPELLHGKTSIVFHEGKGVLDGVPKPFIATRYHSLTVLPETISAEFEVTGKTETGIVMAMRHKELPVEGVQFHPESVLTDGGHRMLANWLKVCGFEVPEATVAQLENGMRTLAAAARQ
>NZ_CP016793.1|WP_065921063.1|2880339_2881656_+|pyridine-nucleotide-disulfide-oxidoreductase
MGAGPAGVYAADILTKSDVDVQIDLFEKLPAPYGLVRYGVAPDHPRIKGIVTALQKVLDKPSVRFFGNVEYGVDVKLDDLRQFYDAVIFSTGASADRELDIPGIDLPGSFGAADFVSWYDGHPDVPRTWPLTASKVAVLGVGNVALDVARILAKTADELLVTEIPANVHEDLAQSPVTDVHVFGRRGPAQAKFTPLELRELDHSPNVEVIVHAEGIEFDEASMHAIRTNKQVEMIVKTLQEWAIRDVGNRPRRLHLHFLEAPVEVLGADHVTGLRTETQELTGDGGVRGTGQFTDWDVQAVYRAVGYLSTHLADIPFDHVSGTVPHLAGRVLDLDEVPMPGVYVTGWIKRGPIGLIGHTKGDALETVTSLLDDAAVLPQATSPSPDAVVQFLEQRAIPFVTNEGWQKLDAHEIALGAAQGRDRVKVVPREEMTSISNG
>NZ_CP016793.1|WP_065915481.1|2881742_2882204_+|hypothetical-protein
MDPDPDLAARLTRFNADLADGNLESGDTVGFACDLLVAGLDTPAMRELAGEPPVQQRASETYDLAQQMLVELGVELMDRERADWFLGREAARKVLAGAPRSEWDGHTFRITLQFSRDDDEVYWALARYDSDPEPFLAYAREYVRMADERLGAP
>NZ_CP016793.1|WP_065915482.1|2882200_2882662_+|hypothetical-protein
MNAELRERLLLLNAGLPSCYGEEAVWLACDLLVAGIETPAIAELAGESPARLTDGEAAPLVDRVLAELGIPRLTEEQAEWVDLREIARGVIAGGRQVEHWACCDVSLIAERWGGDQLWPLIEAVGYEPGPVDPRVLQLLREFVEVADQRITRW
>NZ_CP016793.1|WP_170067916.1|2882648_2882804_-|hypothetical-protein
MYSWIWRHLPGPLFLRVIEAVVLVLAVVALLMFVVFPWAEPLLPFNNVTTE

Crispr_ID: NZ_CP016793_8

• CRISPR_ID: NZ_CP016793_8
• CRISPR_location: 3257514-3257608
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016793_8

Consensus_repeat	Method
GCGGGCGGAACAGGCCTGCGCACCGATCCGCT	CRISPRCasFinder

spacers of NZ_CP016793_8

>8.1|3257546|31|NZ_CP016793|CRISPRCasFinder
GGCCTCGCCCGGTCGCACGCCTGGTGCTTCA

CRISPR arrays and Neighbor proteins around NZ_CP016793_8

CRISPR arrays

The CRISPR arrays of NZ_CP016793_8

>merge|NZ_CP016793|8|3257514-3257608|CRISPRCasFinder
GCGGGCGGAACAGGCCTGCGCACCGATCCGCTGGCCTCGCCCGGTCGCACGCCTGGTGCTTCAGCGGGCGGAACAGGCCTGCGCACCGACCCGCT

>NZ_CP016793|8|6|3257514-3257608|CRISPRCasFinder
GCGGGCGGAACAGGCCTGCGCACCGATCCGCT	GGCCTCGCCCGGTCGCACGCCTGGTGCTTCA
GCGGGCGGAACAGGCCTGCGCACCGACCCGCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_065915768.1|3247905_3248781_+|mycothiol-synthase	unknown	unknown	gnl|CDD|132489
NZ_CP016793.1|WP_083267985.1|3261669_3262350_+|DUF4241-domain-containing-protein	unknown	unknown	gnl|CDD|379427
NZ_CP016793.1|WP_065915774.1|3254848_3256621_-|LCP-family-protein	unknown	unknown	gnl|CDD|273029
NZ_CP016793.1|WP_065915779.1|3263899_3265348_+|multidrug-efflux-MFS-transporter	unknown	unknown	gnl|CDD|129794
NZ_CP016793.1|WP_065915780.1|3265422_3265863_-|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl|CDD|378915
NZ_CP016793.1|WP_065915778.1|3262844_3263546_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697344.1|3252910_3254104_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065915775.1|3259425_3259878_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_083267983.1|3246245_3247061_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP016793.1|WP_065915769.1|3248979_3250086_+|phosphate-ABC-transporter-substrate-binding-protein-PstS	unknown	unknown	gnl|CDD|273374
NZ_CP016793.1|WP_154697346.1|3257890_3258139_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065915771.1|3252105_3252882_+|phosphate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|184587
NZ_CP016793.1|WP_083267984.1|3250119_3251184_+|phosphate-ABC-transporter-permease-subunit-PstC	unknown	unknown	gnl|CDD|273992
NZ_CP016793.1|WP_065915773.1|3254110_3254776_-|phosphate-signaling-complex-protein-PhoU	unknown	unknown	gnl|CDD|273990
NZ_CP016793.1|WP_065915766.1|3245406_3246249_-|DUF2993-domain-containing-protein	unknown	unknown	gnl|CDD|378597
NZ_CP016793.1|WP_154697347.1|3261081_3261537_-|macro-domain-containing-protein	unknown	unknown	gnl|CDD|394878
NZ_CP016793.1|WP_083268818.1|3258438_3259284_-|GGDEF-domain-containing-protein	unknown	unknown	gnl|CDD|143635
NZ_CP016793.1|WP_065921113.1|3259870_3261001_-|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl|CDD|129820
NZ_CP016793.1|WP_065915770.1|3251180_3252095_+|phosphate-ABC-transporter-permease-PstA	unknown	unknown	gnl|CDD|223654
NZ_CP016793.1|WP_065915777.1|3262397_3262880_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065915779.1|3263899_3265348_+|multidrug-efflux-MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	8.27247e-70
NZ_CP016793.1|WP_083267985.1|3261669_3262350_+|DUF4241-domain-containing-protein	gnl|CDD|379427	pfam14025, DUF4241, Protein of unknown function (DUF4241). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 205 and 315 amino acids in length. There is a conserved GDG sequence motif at the C-terminus.	2.34406e-43
NZ_CP016793.1|WP_065915774.1|3254848_3256621_-|LCP-family-protein	gnl|CDD|273029	TIGR00350, Transcriptional_regulator_LytR, cell envelope-related function transcriptional attenuator common domain. This model describes a domain of unknown function that is found in the predicted extracellular domain of a number of putative membrane-bound proteins. One of these is proteins psr, described as a penicillin binding protein 5 (PDP-5) synthesis repressor. Another is Bacillus subtilis LytR, described as a transcriptional attenuator of itself and the LytABC operon, where LytC is N-acetylmuramoyl-L-alanine amidase. A third is CpsA, a putative regulatory protein involved in exocellular polysaccharide biosynthesis. Besides the region of strong similarily represented by this model, these proteins share the property of having a short putative N-terminal cytoplasmic domain and transmembrane domain forming a signal-anchor. [Regulatory functions, Other].	6.45667e-47
NZ_CP016793.1|WP_065915780.1|3265422_3265863_-|nuclear-transport-factor-2-family-protein	gnl|CDD|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	4.1367e-11
NZ_CP016793.1|WP_083267983.1|3246245_3247061_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.14735e-11
NZ_CP016793.1|WP_065915769.1|3248979_3250086_+|phosphate-ABC-transporter-substrate-binding-protein-PstS	gnl|CDD|273374	TIGR00975, precursor_PBP-3_PstS-3_Antigen_Ag88., phosphate ABC transporter, phosphate-binding protein. This family represents one type of (periplasmic, in Gram-negative bacteria) phosphate-binding protein found in phosphate ABC (ATP-binding cassette) transporters. This protein is accompanied, generally in the same operon, by an ATP binding protein and (usually) two permease proteins. [Transport and binding proteins, Anions].	3.77995e-86
NZ_CP016793.1|WP_065915768.1|3247905_3248781_+|mycothiol-synthase	gnl|CDD|132489	TIGR03448, mycothiol_MshD, mycothiol synthase. Members of this family are MshD, the acetyltransferase that catalyzes the final step of mycothiol biosynthesis in various members of the Actinomyctes, Mycothiol replaces glutathione in these species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	2.88109e-109
NZ_CP016793.1|WP_065915771.1|3252105_3252882_+|phosphate-ABC-transporter-ATP-binding-protein	gnl|CDD|184587	PRK14241, PRK14241, phosphate transporter ATP-binding protein; Provisional.	0
NZ_CP016793.1|WP_083267984.1|3250119_3251184_+|phosphate-ABC-transporter-permease-subunit-PstC	gnl|CDD|273992	TIGR02138, phosphate_transport_system_permease_protein_PstC, phosphate ABC transporter, permease protein PstC. The typical operon for the high affinity inorganic phosphate ABC transporter encodes an ATP-binding protein, a phosphate-binding protein, and two permease proteins. This family consists of one of the two permease proteins, PstC, which is homologous to PstA (TIGR00974). In the model bacterium Escherichia coli, this transport system is induced when the concentration of extrallular inorganic phosphate is low. A constitutive, lower affinity transporter operates otherwise. [Transport and binding proteins, Anions].	2.49313e-85
NZ_CP016793.1|WP_065915773.1|3254110_3254776_-|phosphate-signaling-complex-protein-PhoU	gnl|CDD|273990	TIGR02135, Uncharacterized_protein, phosphate transport system regulatory protein PhoU. This model describes PhoU, a regulatory protein of unknown mechanism for high-affinity phosphate ABC transporter systems. The protein consists of two copies of the domain described by pfam01895. Deletion of PhoU activates constitutive expression of the phosphate ABC transporter and allows phosphate transport, but causes a growth defect and so likely has some second function. [Regulatory functions, Other, Transport and binding proteins, Anions].	6.83388e-53
NZ_CP016793.1|WP_065915766.1|3245406_3246249_-|DUF2993-domain-containing-protein	gnl|CDD|378597	pfam11209, DUF2993, Protein of unknown function (DUF2993). This family of proteins with unknown function appears to be restricted to Cyanobacteria.	5.80945e-29
NZ_CP016793.1|WP_154697347.1|3261081_3261537_-|macro-domain-containing-protein	gnl|CDD|394878	cd02908, Macro_OAADPr_deacetylase, macrodomain, O-acetyl-ADP-ribose (OAADPr) family. Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. This family includes eukaryotic macrodomain proteins such as human MacroD1 and MacroD2, and bacterial proteins such as Escherichia coli YmdB; these have been shown to be O-acetyl-ADP-ribose (OAADPr) deacetylases that efficiently catalyze the hydrolysis of OAADPr to produce ADP-ribose and free acetate. OAADPr is a sirtuin reaction product generated from the NAD+-dependent protein deacetylation reactions and has been implicated as a signaling molecule. By acting on mono-ADP-ribosylated substrates, OAADPr deacteylases may reverse cellular ADP-ribosylation.	1.71397e-13
NZ_CP016793.1|WP_083268818.1|3258438_3259284_-|GGDEF-domain-containing-protein	gnl|CDD|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.25193e-50
NZ_CP016793.1|WP_065921113.1|3259870_3261001_-|tRNA-dihydrouridine-synthase-DusB	gnl|CDD|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	6.5541e-141
NZ_CP016793.1|WP_065915770.1|3251180_3252095_+|phosphate-ABC-transporter-permease-PstA	gnl|CDD|223654	COG0581, PstA, ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism].	5.62538e-91

Protein sequences

>NZ_CP016793.1|WP_065915774.1|3254848_3256621_-|LCP-family-protein
MERREDIDPMSLTTEMEAIGEEVKKRREVDHTLARFSAVHDELLEQERQRKERRAKLMPWLNDGDEDEEATQFADPVVVGEESDEKAGPAGRTPQQRKMMRAAKVGAIAAAAVVFVSTGIGWGAMQWADSQFRDIDALGGNSQAVQQAEKQLGDENFLLVGSDTRAGAKAGDNVGTTATEKGARSDVIMLAHIPADRKRMVVVSLPRDVRVDRPDCRSWNSDNGEYGGALAPAKDVMANSVYAEGGPQCVANMMTQLTGLKINHFVSIDFNGFREMATAVGGVEICTSKPIKDNEIGVVIDKPGKHILKGDQALQYVRARYVQGDDASDFARITRQQQFMSSMLRTALSSEVLLNPSRLNDFIKAFTRATVGDNIGVAQLLELGQSLQGLEAGRVSFVTMPHWTDDAKLINNPDDNVERLDEDGVKRLFQSIIDGTPLPLEKPAEQKPGEQNAAPKQGSVIDPKSFSIQVFNGDPANDGGAGRTATALQGVGFQVSSRGDAPERAAKTIIRYAKGFEDKAATLRAAVPKAELVEAPEMGGAVMLVIGADFDGKVVDPKNGSAAPPAGQNQAAGNKNDLSVVNAGQDPCAK
>NZ_CP016793.1|WP_065915773.1|3254110_3254776_-|phosphate-signaling-complex-protein-PhoU
MREAYTDQLEQLAERLADMTGMVAEAMENATAALLQADLGLAEQVISGDQKVDDVRSSIEEQAYALLALQAPVATDLRTVLAVIHAAESVERMGDLALHVAKAARRRHPSSALPEDVKPYFTEMGRIAVKLATEAAEVIRQKDVERARNLEDEDDAMDDIHRHLFSVIMDKEWQHGVAAAVDVTLLGRFYERYGDHAVSVAKRTVFVVTGRMPGYGGDDDI
>NZ_CP016793.1|WP_154697344.1|3252910_3254104_+|hypothetical-protein
MSPQSKSRKKKQGSRPGRRPEQQSPYGALLESAAAVRSESWLLADAWASEVVASLWLGSWRFPEPSQAFESEHEKLVAGVSGAGDEAALTALRALSGVASGDLAAEAAESLAAQGVADPAWFVPGAALEFREAFLVTNLLGDVEVVAITQERAGAVETVLFMRQPVLGATAIELFATPAEGTTALLQDMIASAPGAFRDLIMPMSASEAFDRVWPDIELFWNEEPDEEAEAGLLDDDEEARHPIQLMALADARVRALVPDDYTIPERPDRTDEVVAAFLASEHGAALPDAELAGALARVLAGEAAAQDRDPVAYGPASLTGVLILAVAARLHVSDEDLALLPEVMRAWAYFTADARDLPREEAREAWDAELPTVLAEFSEAYADPELEAERDGQLRG
>NZ_CP016793.1|WP_065915771.1|3252105_3252882_+|phosphate-ABC-transporter-ATP-binding-protein
MAKRLDIKDLNLFYGKFHAVENVSLAVPPKNVTAFIGPSGCGKSTVLRSLNRMHEVAIGARVEGKVLLDGEDIYASTVDPVEVRRTIGMVFQRPNPFPTMSIRDNVVAGLRLSGVKNKKELDEVAERSLRGANLWNEVKDRLDRPGGGLSGGQQQRLCIARAIAVQPDVLLMDEPCSALDPISTLAIEDLITELKKEYTIVIVTHNMQQAARVSDQTAFFNLLGVGQPGQLIEVDDTEKIFSNPGQKATEDYISGRFG
>NZ_CP016793.1|WP_065915770.1|3251180_3252095_+|phosphate-ABC-transporter-permease-PstA
MSTNLADPTRLATPPTFQSVSLPRQIKNGLATALVWGAFLIAVIPLVWVLYTVIQRGFPVVLDGDWWQKSMSGLLARQQGGGAYHAIYGTLVQGLICAVISVPIGIMVAIYLVEYGGRSKLAKATTFMVDILTGVPSIVAALFIYTVWITYFGLGRSAFAVSLALVLLMVPVIVRTTEEMLKIVPDELREASYALGIPKWKTIVKIVIPTALSGILTGIMLALARVMGETAPVLVLAAYAPFINYNLFDGPMASLPLMMVNERNNPTQAGFERIWGAAITLVVLITLFNLLATVISRALAPKTK
>NZ_CP016793.1|WP_083267984.1|3250119_3251184_+|phosphate-ABC-transporter-permease-subunit-PstC
MNDPVVAKRPAGSGASGAERGVAAAPHASEAPIPPTPEAPETPKAPHVRPGDRIFRGLATGSGVFIVVLIGAIGLFLILQAIPSLGLDNVNFLTSREWNTTDPSNLRFGILDLTLVTVVVAVVALLIAMPIALGIALFLTQYAPRNLARPFAYMVDLLAAVPSIVFGLWGLFVLGPVLFPFSEWLIANLGWIPLFAKGNVNVQLGGTIFTAGIVVAVMILPIITAVSREVFERTPTMHIEGAIALGATKWEVVRTTVLPFGKAGYVSASMLGLGRALGETIAVAIILSTATSSFGWSLFDGGSTFASKIALAAPEFNDARSAGAYIAAGLVLFVLTFVVNAIARSIVAGHKEYE
>NZ_CP016793.1|WP_065915769.1|3248979_3250086_+|phosphate-ABC-transporter-substrate-binding-protein-PstS
MKIQRHGAVLGLVAASALLLSACGSDNNTGTGGSTNTPAASGVECGGKTNLNAEGSSAQKNAVDAFVQAYQAACPGTNLAYNPSGSGAGVKNFNAAQVDFGGSDSALKEGAETEAATKRCQGNPAWNLPLVFGPVAIGYKVSGVDSLVLDAKTTAAIFSGTVKKWNDPAIKALNGSANLPDKDIAVIYRSDESGTTDNFQKYLKVAGGWTKGDGKQFKGGIGEGKEKSAGVAQAVGSIDGAITYVEWSFAQDNKLSIAKIDSGAGAVELTAETAGKAIDGAKIKGTGNDLVLDLDSIYGSKTAGSYPLLLATYEIVCSKGYDADTAKAVKAFLTVAATTGQEQLAEAGYVPLPKAFQDKLLTAVKAIA
>NZ_CP016793.1|WP_065915768.1|3247905_3248781_+|mycothiol-synthase
MAELSWHDELTSDQAAEVARLLSAAEATDGVAPVGEAVRLRMRPGATGSRHLLATVDGELAGYAHLDVLGDSGGHQVAELAVHPGHRHRGVGAELVTALPAENLRIWAHGGHPDAARLAQELGFQKARELLRMRLRVQDDLPEPTLPDGVTIRSFVPGKDEAAVVYVNHRAFDWHPEQGAMSIEDVRAKEDEPWFDPAGFLLAFDSDDRLVGFHWTKVHTPALGEVYVVGVDPDRQGGGLGKALTLAGLRHLRDQRVEEVMLYVESDNTAAVRVYTKLGFTLWDADVQYAR
>NZ_CP016793.1|WP_083267983.1|3246245_3247061_-|alpha/beta-hydrolase
MTETIPVHPEKVPGQEAVLTVVSTSVTPVTSMSHDGVRLHGVHHKGESSLVFVVGHGFTNNVTKPYVARVLARFARHAGVVAFDFRGHGRSGGRCTVGADEVHDVEAAVRTARELGYTRVATVGFSMGASVVIRHAALEETKPDAVISVSGPARWWSRETAPMRRVHWLLEQPHGKLAARAIGVRLGDPWVQVPESPLEVVSRVTPTPLLVVHGELDHYFGPEHAKSLHRASSGHAQLWLEPGMRHAESATTPDLVDRMAAWTAGNVEDEG
>NZ_CP016793.1|WP_065915766.1|3245406_3246249_-|DUF2993-domain-containing-protein
MTAGHSGQSGARKVKRKSRRGKFLVIAVLVLGVLLVAADFALAAAAEYQIAQRMREKLQLKEDPSVRISGFPFVLQAVRGDYTRVEIDAYGVPIKDEQKDIELRDLDIEADLHHTRVELGDLLAGNVSKATIDQVDGKVRIKALDLNRLANQVTPFDKLSIEPDNRTTTATPTPVAPETPKPKTTAAIKLSGQTNLAGKTVTVTAYGQIALVDGAIQISVDDIELEDASLKQLVPQLRNALAIKIDPGALPFGAKPTAVEVENGAFTLSGVITDVPLEQR
>NZ_CP016793.1|WP_154697346.1|3257890_3258139_-|hypothetical-protein
MEGAGGLSVSDLIEQHSRTNIPRPVPPGSPDASTTGRRALPEDPPAAGRRSLPEPPADQRQPRHRRASPVARRRPDRSAAQA
>NZ_CP016793.1|WP_083268818.1|3258438_3259284_-|GGDEF-domain-containing-protein
MTALRPEIAENEQADLAVGQGPKLVGLHESIATLLASRGQWRQAYQHLRSALDLVHADQDEEPHVPEQLRREVDRLRREHAEAREQSLRDSLTDSYNRRYLDQQLIDLLAEHGACRHGLAIALIDLDWFKQVNDTFGHLLGDRVLQRVVELLQQDLPEGAFCARYGGEEFVLVLPRVDAVAAVEVAEAARERVERHPWHEIAPGLRVTVSAGLAYEPPADEAPQRPAVSAEQQLLRADSLLYSAKQSGRNAVAYRSDGRVRLAGAASGRRAIAETRVIGYR
>NZ_CP016793.1|WP_065915775.1|3259425_3259878_-|hypothetical-protein
MAERAAVLLFSLLLLAGCGGPVTGTARPVSLSDGDRAKFREYYERVNKAGDEGASEQTKLLKDTQHPDFRQKTCDMRGATIKVEPTWSTLRVDADWAPPGEKSHPRGDVYVVAVTVTLRQEDAVVGSQIGSMHVVLLDDEVYGFAPCLGG
>NZ_CP016793.1|WP_065921113.1|3259870_3261001_-|tRNA-dihydrouridine-synthase-DusB
MGAVSAPTLKIGPYAVDPPVVLAPMAGITNVAFRQLCRQYGAGLYVCEMITARALVERDPMTMHMITFDEGENPRSMQLYGVDPKNVGEATRMIVDEDLADHMDMNFGCPVPKVTRKGGGAALPYKRELFRQIVRAAVRNAGDMPVTVKFRIGIDDDHLTYLDAGRIAQDEGARAVALHARTASQRYSGKADWSAIARLKEAVTSIPVLGNGDIFSAQDALDMVARTGCDGVVVGRGCLGRPWLFRDLQAAFRGEEVPPGPTLGEVAEVLRTHARLLAAHDGEHKGLRDLRKHMAWYWHGFPVGGDTRRAFAMVSSLQELDDLIGQLDADVPFPANAEGPRGRQGSAAKVVLPEGWLDDPEDATVPAGADVMHSGG
>NZ_CP016793.1|WP_154697347.1|3261081_3261537_-|macro-domain-containing-protein
MGVIEVVLGDITRENVDAIVTAPALAPCRPGQAVAMPAFDLAPVRYVSHTVGPAWEGGDHGDAGRRRGGPAGRVRPGHVRRAEHGTGEAGRRAVPDVRRAGGADRARRVQRARDRAGGAEVDRAGPLLRDGGQADVGVHGGRGTPVDERRT
>NZ_CP016793.1|WP_083267985.1|3261669_3262350_+|DUF4241-domain-containing-protein
MGASQLIKTGFELFFEEGPVGRRTGGDEQQVISVREVGWLAMPTGRLVAADPFVLWPEDAEPFTATFEPGKYPVTVSLVSWLDRDGFPDVRQGYRVAAAKLTVRDEPAYVWEPALVPGEHVAPMLPGQRFGYGVESSTGAFFDLSAAPAVDRLAGDDLSGDCALIDALSAVGGGRGPANVTDVESGLNVVAFSTGWGDGVYPTWVGRNPSGDPVAFVTDFFVINRF
>NZ_CP016793.1|WP_065915777.1|3262397_3262880_+|hypothetical-protein
MSEAEDSEQHRLARNLNELMQELRVAQASVQILFGFLLSIAFTEKYASVGAYIRVTHLVTILCAAVAVAFLTAPAAWHRVLFRQGRREDVVGSGNTFALVGLAFLALAMTGTVLLVAEMVIGGWPAIAVGVLGFFIFAGLWFAWPSARRSAEGADEGERA
>NZ_CP016793.1|WP_065915778.1|3262844_3263546_-|hypothetical-protein
MTNRFPNGWVAGVALVLGPVLLLAGTLLRVQFHYFFPDQLKAAADHPALLTAAYTAFLAGHVVMWPAVAEVARRIAPKRPMWAAWGGVLVTVGLFARTFHAGVDHAAFSAVRHRGVEEATKLVADGYGDLHLFSYLSFTIMFGWYVLAIGAYLGGVLGPVRAVALATTGLLPLGVLKGAEVLSVVGTAGLCVALVPLGIRVLREMPRLGRRALVLAAPVAAGLGALAFVSTLG
>NZ_CP016793.1|WP_065915779.1|3263899_3265348_+|multidrug-efflux-MFS-transporter
MPAAIQDRPTAQKGRTPLVVRLLVLATFVVILNETLMINAIPRLMESLHVSEQAAQWVSTAFMLTMAAVIPITGWFLQRVTTRQGYLIAMSVFMAGTAISAAAPTFTVLLAGRIVQAAGTAVMMPLLMTTLMTVVPEQDRGRVMGNVTLAISVAPAMGPAVSGLILQLGSWRLLFVAVLPIAGAVTYFGLRQLTNIGEPKVSTIDWLSAALAALGFGGLVYGLSLFGEGTDHLGPTIGIVVAGAATIAFFVVRQLRLQRTGAPLMDLRALRHRTFALSLTLMCIAFMALMGSMMLLTLYLQNLRSLSPLETGLLLMPGGLAMGLLGPTVGKLYDRLGARPLIIPGSIAIVLSLAGYTQVSTTMPFWQVLALHALLMIALAATFTPIFTLGMGALPADMYPHGSSILGTLQQVAAALGTALVVTVMSARSSSLVAEGALLPAAQLSGMRLAFVVATALAVATIVVAFLLPNRTASAEGAVGHH
>NZ_CP016793.1|WP_065915780.1|3265422_3265863_-|nuclear-transport-factor-2-family-protein
MSHNSGAIVQAAWKAFASRDADRVAAVFTEDAEWIAPAGNATAVALDVPSHMVGREAITRFLVVDFPRLFVSDVAVAFRGFHVDGERVVVEETMTAVLANGNQYANDYCLVFELRDGLVHRVREYMDTARAQRMILGETSVPARTG

Crispr_ID: NZ_CP016793_9

• CRISPR_ID: NZ_CP016793_9
• CRISPR_location: 4182327-4182551
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP016793_9

Consensus_repeat	Method
GCGGCGGTTCGCCTCCTCGGTGGCCTCGCGCACGCGGCG	CRISPRCasFinder

spacers of NZ_CP016793_9

>9.1|4182366|60|NZ_CP016793|CRISPRCasFinder
GTTCGCCTCGTCCGTGGCCTCCTGGATGCGGGCGGTCGCCTCGGTGACCGCGTCGTGGCG
>9.2|4182465|48|NZ_CP016793|CRISPRCasFinder
TTCGGCTTCGGCCTTGGAGTTCGCCTGCTCCTGTGCCACGGCGGCCCG

CRISPR arrays and Neighbor proteins around NZ_CP016793_9

CRISPR arrays

The CRISPR arrays of NZ_CP016793_9

>merge|NZ_CP016793|9|4182327-4182551|CRISPRCasFinder
GCGGCGGTTCGCCTCCTCGGTGGCCTCGCGCACGCGGCGGTTCGCCTCGTCCGTGGCCTCCTGGATGCGGGCGGTCGCCTCGGTGACCGCGTCGTGGCGGCGGCGGTTGGCCTCCTCGGTGGCCTCGCGCACGCGGCGTTCGGCTTCGGCCTTGGAGTTCGCCTGCTCCTGTGCCACGGCGGCCCGGATCCTCGTGGCCTCCTCGGTGACCTCGCGCATCCTGCG

>NZ_CP016793|9|7|4182327-4182551|CRISPRCasFinder
GCGGCGGTTCGCCTCCTCGGTGGCCTCGCGCACGCGGCG	GTTCGCCTCGTCCGTGGCCTCCTGGATGCGGGCGGTCGCCTCGGTGACCGCGTCGTGGCG
GCGGCGGTTGGCCTCCTCGGTGGCCTCGCGCACGCGGCG	TTCGGCTTCGGCCTTGGAGTTCGCCTGCTCCTGTGCCACGGCGGCCCG
GATCCTCGTGGCCTCCTCGGTGACCTCGCGCATCCTGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_154697408.1|4175786_4176146_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_083268066.1|4188821_4190327_+|GAF-domain-containing-protein	unknown	unknown	gnl|CDD|226951
NZ_CP016793.1|WP_065916516.1|4190317_4190971_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP016793.1|WP_065916518.1|4192563_4194093_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|312032
NZ_CP016793.1|WP_065916511.1|4184729_4185335_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NZ_CP016793.1|WP_065916499.1|4173331_4174324_+|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl|CDD|237724
NZ_CP016793.1|WP_065916515.1|4188014_4188617_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065916510.1|4183238_4184552_-|crotonyl-CoA-carboxylase/reductase	unknown	unknown	gnl|CDD|188164
NZ_CP016793.1|WP_065916504.1|4178020_4178707_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|131480
NZ_CP016793.1|WP_065916500.1|4174941_4175643_+|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	unknown	unknown	gnl|CDD|184702
NZ_CP016793.1|WP_065916513.1|4185869_4187060_+|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl|CDD|180261
NZ_CP016793.1|WP_065916506.1|4179032_4179236_+|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl|CDD|274226
NZ_CP016793.1|WP_065916512.1|4185291_4185744_-|methylmalonyl-CoA-epimerase	unknown	unknown	gnl|CDD|319912
NZ_CP016793.1|WP_065916503.1|4177479_4178028_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|224584
NZ_CP016793.1|WP_065916517.1|4191016_4192552_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|312032
NZ_CP016793.1|WP_065916507.1|4179232_4179856_-|DUF3558-family-protein	unknown	unknown	gnl|CDD|378803
NZ_CP016793.1|WP_065916508.1|4179906_4181682_-|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl|CDD|181133
NZ_CP016793.1|WP_065916505.1|4178703_4179000_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065916514.1|4187070_4188018_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl|CDD|224617
NZ_CP016793.1|WP_083268065.1|4176177_4177209_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|236612

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065916516.1|4190317_4190971_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.24685e-71
NZ_CP016793.1|WP_065916518.1|4192563_4194093_-|alpha/beta-hydrolase	gnl|CDD|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	4.23678e-24
NZ_CP016793.1|WP_065916499.1|4173331_4174324_+|dihydroxyacetone-kinase-subunit-DhaK	gnl|CDD|237724	PRK14481, PRK14481, dihydroxyacetone kinase subunit DhaK; Provisional.	0
NZ_CP016793.1|WP_065916510.1|4183238_4184552_-|crotonyl-CoA-carboxylase/reductase	gnl|CDD|188164	TIGR01751, crotonyl_CoA_reductase, crotonyl-CoA carboxylase/reductase. The enzyme represented by this model can convert crotonyl-CoA to butyryl-CoA (crotonyl-CoA reductase activity), but more importantly, in the presence of CO2, generates (2S)-ethylmalonyl-CoA. In serine cycle methylotrophic bacteria this enzyme is involved in the process of acetyl-CoA to glyoxylate. In other bacteria the enzyme is used to produce extender units for incorporation into polyketides such as tylosin from Streptomyces fradiae and coronatine from Pseudomonas syringae.	0
NZ_CP016793.1|WP_065916506.1|4179032_4179236_+|zinc-ribbon-domain-containing-protein	gnl|CDD|274226	TIGR02605, CxxC_CxxC_SSSS, putative regulatory protein, FmdB family. This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions].	1.34003e-10
NZ_CP016793.1|WP_065916504.1|4178020_4178707_+|alpha/beta-fold-hydrolase	gnl|CDD|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	4.50514e-23
NZ_CP016793.1|WP_065916500.1|4174941_4175643_+|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	gnl|CDD|184702	PRK14484, PRK14484, phosphotransferase mannnose-specific family component IIA; Provisional.	5.41026e-38
NZ_CP016793.1|WP_065916513.1|4185869_4187060_+|acetyl-CoA-C-acetyltransferase	gnl|CDD|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0
NZ_CP016793.1|WP_065916511.1|4184729_4185335_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.54553e-11
NZ_CP016793.1|WP_083268066.1|4188821_4190327_+|GAF-domain-containing-protein	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.24757e-31
NZ_CP016793.1|WP_065916503.1|4177479_4178028_+|GNAT-family-N-acetyltransferase	gnl|CDD|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	1.23291e-24
NZ_CP016793.1|WP_065916517.1|4191016_4192552_-|alpha/beta-hydrolase	gnl|CDD|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	2.50132e-18
NZ_CP016793.1|WP_065916507.1|4179232_4179856_-|DUF3558-family-protein	gnl|CDD|378803	pfam12079, DUF3558, Protein of unknown function (DUF3558). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.	0.00314834
NZ_CP016793.1|WP_065916508.1|4179906_4181682_-|NAD(P)-binding-domain-containing-protein	gnl|CDD|181133	PRK07819, PRK07819, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	2.87548e-115
NZ_CP016793.1|WP_065916512.1|4185291_4185744_-|methylmalonyl-CoA-epimerase	gnl|CDD|319912	cd07249, MMCE, Methylmalonyl-CoA epimerase (MMCE). MMCE, also called methylmalonyl-CoA racemase (EC 5.1.99.1) interconverts (2R)-methylmalonyl-CoA and (2S)-methylmalonyl-CoA. MMCE has been found in bacteria, archaea, and in animals. In eukaryotes, MMCE is an essential enzyme in a pathway that converts propionyl-CoA to succinyl-CoA, and is important in the breakdown of odd-chain length fatty acids, branched-chain amino acids, and other metabolites. In bacteria, MMCE participates in the reverse pathway for propionate fermentation, glyoxylate regeneration, and the biosynthesis of polyketide antibiotics. MMCE is closely related to glyoxalase I and type I extradiol dioxygenases.	1.5918e-48
NZ_CP016793.1|WP_065916514.1|4187070_4188018_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl|CDD|224617	COG1703, ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism].	1.29306e-116
NZ_CP016793.1|WP_083268065.1|4176177_4177209_-|helix-turn-helix-domain-containing-protein	gnl|CDD|236612	PRK09685, PRK09685, DNA-binding transcriptional activator FeaR; Provisional.	2.16479e-33

Protein sequences

>NZ_CP016793.1|WP_065916508.1|4179906_4181682_-|NAD(P)-binding-domain-containing-protein
MAREISTVGVVGFGTMGAGIVEVLARTGLAVRVVDVDAAGLERGLGHLEHSTTRAVRREKLTEDEKTALLGRVTTSLALADLADCDLVVEAVPESIELKAGIFRELDQILKPEAVIASNTSSLSITEIGVHTGRPGKVVGLHFFNPTQVLKLVEVVRTVVTEPDVIADVVAFAERLGKSPVVIGDRAGFIANALLFPYLNHAVKMLESKYATREDLDAAMRYGCGYPMGPLALLDLIGLDTAYEILDTMYHQSRNRLHAPAPLLKQMITAGLLGRKTGRGFYTYDGPDSPTVVADAHTPSTVDSSVPSREVRRVGVIGTGTMATGIAEVFAKRGYDVVLRARGLDKAEKAIAAVRRSLERAVSKGKLSEADRDAALARITPAVEFVELADCDLVVEAVAEEIGIKKEVFAALDEACKPGAVLATTTSSLPVVEIAAATSRPQDVVGLHFFNPAQVMKLVEVVETISTGADVVATARKICLDLGKHPVHCGDVAGFIVNALLFPYLNDAVKMLEAHYAEADDIDNAMKVGCGLPMGPFALLDVVGLDVSLAIERTLYLEFREPGFAPAPLLEHLVTAGRLGRKTGKGFRDYS
>NZ_CP016793.1|WP_065916507.1|4179232_4179856_-|DUF3558-family-protein
MRRLVLLLAVLLLASGCAGKTIEGSPKAQDAIDAASPFDQEAPSSEDPSPEDPTSEDPSAEDPEDPDTAPIDGEVQGVCAVLKWTDLPYPGAKPETPPTQINYDSTFDQSCRWTTKVDNVEVGVSLRFREGRQITIERTTGEYDVNGQKVTYLDRSDDPEVQPTCVLVAPYDGGGLGIIVIDSTGKFGPVCEQGRKIAETMLSRTPN
>NZ_CP016793.1|WP_065916506.1|4179032_4179236_+|zinc-ribbon-domain-containing-protein
MPTYEFRCRTCDDTFELKRPMSESSAPASCPDGHADTVKLLSMAGIGGTAAQPSGGGGGCCGGGCCG
>NZ_CP016793.1|WP_065916505.1|4178703_4179000_-|hypothetical-protein
MPRRNSPKPEEHRPLGGGVGWARTEVGPGGEEYLVRAISGAQAQKTYRCPGCDHEIRPGVPHVVAWPAHEAGSAEERRHWHQGCWDSRGRRGPTSKRF
>NZ_CP016793.1|WP_065916504.1|4178020_4178707_+|alpha/beta-fold-hydrolase
MDDLVLLHAFPLDARMWDVPGARTPSLRGSGEPDLTTVARGVLAGLDDLDQFVLGGCSMGGYVAMALLRIAPERVKGLVFVDTKHTADTEEAAANRHAMADRVEREGVGDWLADSMVPNLLGPDASADAEALTRAMILDQRAEDVAWWQRAMARRPDSTGVLESLDVPSLVLVGEHDQLTPPAVAAKLAVTLKHSTSERIEDAGHLPPVEQPAEFRARLERWRTQVGI
>NZ_CP016793.1|WP_065916503.1|4177479_4178028_+|GNAT-family-N-acetyltransferase
MFSTPLGDDGAELRPLEPWHAPEFFANIERGREFIGQYIALPDAVPDVEAARAYLTNYAEKAKTDTGRICGIWLDGQLVGGVLFRVMDLRQGTAEAGCWLEPAAAGRGLVTRAARVIIDWAVRERGVHRVEWVVSSANAPSIAVARRLGMTKDGVLRQHYLYRGVRHDMEVWSVLAPEWTDG
>NZ_CP016793.1|WP_083268065.1|4176177_4177209_-|helix-turn-helix-domain-containing-protein
MAIVIDTDDVDAGSAFDHFRDGLSRAQVPMDIRCATPGEFHARHRSVDLGGVSTASVLWRPGRYEVARTSALISRSDPGVYRVLLNLSGTSEFLHQGRHATLGAGEMALFDTSAPFFGRRAPGADRTGRSIMLTLPHTALPLPPRTVRTALGAVLPSRSGTGGLVRGLLQEIDVRAGAGEIAAAHRLSAALLDVLVVHLAECSGTTSPAVRESGERTTWLRVRAFVAERLGDPGLSPECVAAAHHMSVRTLQRLFSHHNTTVAGWIRAQRLERCRHDLLDPHTAATSVRAIAHHWGFSDQAHFTRAFRTAYGMTPLQCRPAAGADGQRVGAQTQEFSPPPGEE
>NZ_CP016793.1|WP_154697408.1|4175786_4176146_-|hypothetical-protein
MTQRLSRTRRASRIAAVLAVPLALVLTATSAHAHYQEAKHGDDLGWVDANHWTIGVCDNEADGNGVRTEYRTADGNTDYVGDWNGSGNGCNSEVVFDGSYVTQFQVCEETKGCSGWKNA
>NZ_CP016793.1|WP_065916500.1|4174941_4175643_+|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM
MTAAVPARVGLVVVSHSDMLANGVAELAAQMAPDVTVVPVGGTEEGGLGTDYGSVVEALADADSGSGVVLLYDLGSAKMTAEMAVESADDPSRYAVVDAPLVEGAVAAAVTAQGGASLADVAVSAEGASGEAPVAPVPPALHLVSDAVSAEVALTNEAGLHARPAALLARTVAELDADVVVRYGAEEANAASVLGLMGLSAPGGKSITVVATGKDAREAVRRIEELAERGFDD
>NZ_CP016793.1|WP_065916499.1|4173331_4174324_+|dihydroxyacetone-kinase-subunit-DhaK
MKKIINDPETVVQDALRGMQAAHPDLLSVRYDPAVITRADAPVRGKVAIISGGGSGHEPLHGGFVGRGMLDAACPGAVFTSPTPDQVAAAVEATDGGAGALLLVKNYTGDVMNFEMAGELAESEVRSVVIDDDVAVQDSLYTAGRRGVGGTVLVEKIVGAAAERGADLAACEALANRVNASVRSMGLALTSCTVPHVGTPSFELAEDEMEIGIGIHGEPGRQRVPVGSAAEMVAALLDPVVADLPFAEGDRVLLFTNGMGGTPLIELYLAHGIAEAYLAERGITVERRLVGPYITSLEMQGMSLTLLKLDDELAGLWDAPVHTPALRWGV
>NZ_CP016793.1|WP_065916510.1|4183238_4184552_-|crotonyl-CoA-carboxylase/reductase
MQKILDAILADELDAIGSLDVPESYRGVTVHADEADMFSGLETRDKDPRKSLHIDEVATPELGPGEALVAVMASAINYNTVWTSIFEPVSTFGFLRKLGGRHDLPYHVVGSDLAGVVVRTGPGVTAWKPGDRVVAHCLDVPLEAPDGHNDTMLDPQQRIWGFETNFGGLADLALVKSNQLMPMPRHLTWEEAASPGLVNSTAYRQLVSTNGANMKQGDTVLIWGASGGLGSYATQFALNGGATPVCVVSSPEKAEIVRSMGAELIIDRSAEGYRFWKNEHEQDPKEWKRFGAKIRELTGGEDPDIVFEHPGRETFGASVFVARKGGKIVTCASTSGYMHQYDNRYLWMNLKHILSSHFANYREAWEANRLIAKGKIHPTVSKVYSMDETGQAAHDVHRNAHQGKVGVLCLAPEEGLGVLDHEMRAKHLTAINRFRGV
>NZ_CP016793.1|WP_065916511.1|4184729_4185335_+|TetR/AcrR-family-transcriptional-regulator
MSRAHTPAEERVADSAKERILAAAEELFAESGFDATPTSRVADRAGVPKGLVHYYFNRKKDLLVALVARLPDSTVDHRGVVVAGDVAESLRRLVAALDAQLTASPLLSHLLWREADAHPAVRDAMRARYDDVAAQIEQVILAAGGPAVAADDVAAAAALLALAVSYRHSVARHSDEDDPIDRELTFVASALTRQPPARPAR
>NZ_CP016793.1|WP_065916512.1|4185291_4185744_-|methylmalonyl-CoA-epimerase
MNADIARFVTAIDHVGIAVPDLDVAIAFYRDNFGLEVAHEEVNEEQGVREAMLHAPGDHGGTAIQLLAPLTESSTIAKFIGRSGPGLQQLAYRVSDVDVAADALRRKGLRLLYDNAKRGTSNSRVNFVHPKDAGGVLIELVEPAAAGSAH
>NZ_CP016793.1|WP_065916513.1|4185869_4187060_+|acetyl-CoA-C-acetyltransferase
MSGSVIVAGARTPMGRLLGSLKDFSGAQLGGVAIKAALERAGVAPEQVEYVIMGQVLTAGAGQIPARQAAAAAGIPMTVPALSINKVCLSGIDAIALADQLIRAGEFDVVVAGGQESMTQAPHLLPKSRGGFKYGDVSMVDHMAHDGLFCAFDQVAMGSSTEKYNGRHGVTREEQDAFSARSHQLAAKAAENGVFAQEIAPVEIPQRKGDPVVFSTDEGVRADTTAESLGKLRPAFAADGTITAGSASQISDGAAAVVVMSKAKAEELGLEWIAEIGAHGVVAGPDASLHEQPSNAIKAACAKEGISPADLDLVEINEAFAAVGIVSTRQLGISEDKVNVNGGAIALGHPIGMSGARIALHLALELQRRGGGVGAAALCGGGGQGDALIIRVPSKA
>NZ_CP016793.1|WP_065916514.1|4187070_4188018_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MGAVDVAGLVGRARDAEPRAVARLISLVEQGSSALPEVAAALAPFTGNAQVVGITGAPGVGKSTSTNALVRAFRTAGKRVAVIAVDPSSPFSGGALLGDRVRMGDHATDEGVFIRSMATRGHLGGLSWATPQALRVLDAAGFDVVLVETVGVGQSEIEVVALADTTLVLLAPGMGDGIQAAKAGILEIADVFVVNKADRDGADQTARDLKYMISLGRRDRSGPLWRPPVVKTVAASAEGVDAVVEAIAAHQAWMAEHGELAARRLRRAGAEIEAIAVDRVRTRFGPVDALAGRVVAGELDPFAAAEQLISGNLRA
>NZ_CP016793.1|WP_065916515.1|4188014_4188617_+|hypothetical-protein
MTAWGEPVVVDLGASDTRKVLLGGSLAGGLGVLALFGAVSAFVSGEPVGGSIAAVIGLAFTFIGVMALVKFKTISRPRKLVIEPQGIRLDDPRGTPWAVAWQDLGAISISRTRERAVELADALVRRTLVRVDLHPLDPARFRPAHPAMEPLWEFHRVQNGYRLPLGDSAPMIAPIDAGLRMYAPQIYRGVIDEGFTVGLH
>NZ_CP016793.1|WP_083268066.1|4188821_4190327_+|GAF-domain-containing-protein
MGGNLSTDQRLLDVVLSFAGTDSLPELLHLVVESACELTGASYGALAVVNGHRELLEWSGQDPDHITTGDPRSINATEFVGVPVQVDGQEFGNLYLAGKAVFDEHDRETAATVATAAGIAIRRQRAHDQVRRREGWLSAAAEVTTALLTGTGGRDALYLVAKRARRAANANFSALVLPDHAGELVIEVTDGGTYDAEGMRLPKENTVSYRVYESGRAEAHEAGQVPTVPGPVVVVPLSAGERRLGVLIVARTRSQPPFEDLELVEAFAVQAALVLEFTQAQGDTERLAVLEERDRIARDLHDLVIQRLFGLGLGLQGLTGAITTPEITKRISGFVEEVDHTIREIRRTIFSLQEPLTNTTSLRGQLLRAVHDSAQLLGFEPDVSLEGPLDTVVPDQLRPDLVATLREALTNVARHARAKHVKVAIGVNREMTALELTVKDDGRGLPLSDDSHAQAHHAGGLANMAARARRHHGNCSVDSVPGAGVRITWFVPLALQEATWR
>NZ_CP016793.1|WP_065916516.1|4190317_4190971_+|response-regulator-transcription-factor
MAIAVLLVDDHEIVRRGLVQLLAQADDIAVVGQADSATSAITQAPRLKPDVAIIDVRLPDGDGVTVCREIRSLVQPPPACLMLTSYSDDEALFGAIMAGASGYMLKEVSGNDLVAAVRTLASGGSLLHAGVTSTVLQRLRGGSEEDPRYAALSPQEKRILDLIAEGMTNRQIANRLFLAEKTVKNYVSSLLHKLGFDRRTEAGVYAARRRRTHPGTF
>NZ_CP016793.1|WP_065916517.1|4191016_4192552_-|alpha/beta-hydrolase
MHRKKIAAALVAVTATSLLIAPQAQAKTPFANQQIQWQRCFDPVPPGFPPGAERLECGTFTAPMDWNNPNNGKTITIAVSRTRPKSGTAKTTVFTNPGGPGGEGRIMPLIFLERPKLSENAEIIGIDVRGTGASDNLTCGMFDTLGSTDPRDRSKANLDLLYGGMELQAKFCQTKSGELGKHVTTEQTVRDLDLLRQVLGRKKVDWLGYSGGSWMGAYYATYFPKTLDKIVLDSNTEFTAPWQTVFGDFGLGFERRFRVDFAPWVAKYDHLYHLGKTGEEVRQTYERTRAKLAQQPVTLPDGVYYPVTLDFLLFDGQYSKYSFEQTAQKFAEIAGAVPVQFGAQASYPDFVVGTRYAIVCNDTPFHGGRGYLERDAVRDGAKWPLLGYYQLMGPCAYWDRPKVNLKQPTGIGVSPTLMVQSVRDAPTPIEGARKAHARFAGSRMLTVQDEGDHGIYGFDNACVNDVVERYLVDRVTPAGDLSCPGVPLPEPGAGQASVLDQAKRLAVQLGW
>NZ_CP016793.1|WP_065916518.1|4192563_4194093_-|alpha/beta-hydrolase
MRRKQLAAALAVATATSLLIAPQASAAPAQTINWQKCFDSPPPGAPPGAERLECGTFTAPMDWNNPGNGKTITIAVSRLTPKTGTAKSTVFTNPGGPGGAGRSMPLIYLDRPKLSENAEIIGIDVRGTGASSNVTCGMFDTFGSTDPRDRSKANLDLIYGGMELQAKFCQTKSGELGRNVTTEQTVKDLDLLRQVLGKKKVSWLGYSGGSWMGAYYATYFPKTLDRIVLDSNAEFTAPWQTVFGDWGMGFERRLRVDFLPWVAKYDSVYHLGKTADEVWQTYERTRKNLNAQPVTLPEGTYNGVALDFMTRGGLYDKGAFDGTATKIAELAGAAPRRMSAQATYPDAFSGTLYSILCNDTPWRGGREYLERDAVRDGARWPFFGHYQLAGPCTFWDRPNVHLKQPTGKGVVPTLMVQSVRDAATPLEGAQRAHRGFENSVMLTVENEGDHGIYGFSNPCVNDVVERYLVDGVAPTKDLTCPGVPLPAPGDTVQNPLTKARQLATQLGWQ

Crispr_ID: NZ_CP016793_10

• CRISPR_ID: NZ_CP016793_10
• CRISPR_location: 5214034-5214108
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016793_10

Consensus_repeat	Method
GCGCGGGTGTTCGCGGAAACGGT	CRISPRCasFinder

spacers of NZ_CP016793_10

>10.1|5214057|29|NZ_CP016793|CRISPRCasFinder
TGCAGGCTGGCGGTGGGCGGGTGCCGGGT

CRISPR arrays and Neighbor proteins around NZ_CP016793_10

CRISPR arrays

The CRISPR arrays of NZ_CP016793_10

>merge|NZ_CP016793|10|5214034-5214108|CRISPRCasFinder
GCGCGGGTGTTCGCGGAAACGGTTGCAGGCTGGCGGTGGGCGGGTGCCGGGTGCGCGGGCGTTCGCGGAAACGGT

>NZ_CP016793|10|8|5214034-5214108|CRISPRCasFinder
GCGCGGGTGTTCGCGGAAACGGT	TGCAGGCTGGCGGTGGGCGGGTGCCGGGT
GCGCGGGCGTTCGCGGAAACGGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_065917310.1|5205235_5206072_-|fused-MFS/spermidine-synthase	unknown	unknown	gnl|CDD|223498
NZ_CP016793.1|WP_065917318.1|5215770_5216886_+|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|173849
NZ_CP016793.1|WP_065917326.1|5226944_5228633_+|hypothetical-protein	unknown	unknown	gnl|CDD|224331
NZ_CP016793.1|WP_083268872.1|5212579_5213965_+|TIGR03084-family-protein	unknown	unknown	gnl|CDD|274423
NZ_CP016793.1|WP_065917315.1|5212020_5212380_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_179953699.1|5206408_5207830_-|YibE/F-family-protein	unknown	unknown	gnl|CDD|377940
NZ_CP016793.1|WP_083268149.1|5224449_5225586_+|S8-family-peptidase	unknown	unknown	gnl|CDD|173790
NZ_CP016793.1|WP_065917319.1|5216885_5218436_+|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl|CDD|227136
NZ_CP016793.1|WP_154697493.1|5222181_5223099_-|hypothetical-protein	unknown	unknown	gnl|CDD|237361
NZ_CP016793.1|WP_065917309.1|5204407_5205037_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_083268871.1|5208856_5209477_-|nicotinamide-mononucleotide-transporter	unknown	unknown	gnl|CDD|377432
NZ_CP016793.1|WP_065921347.1|5211443_5211971_-|DUF4865-family-protein	unknown	unknown	gnl|CDD|379781
NZ_CP016793.1|WP_065917325.1|5225695_5226874_+|S8-family-peptidase	unknown	unknown	gnl|CDD|173790
NZ_CP016793.1|WP_065917327.1|5228609_5228897_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065917320.1|5218443_5220276_+|ATP-grasp-domain-containing-protein	unknown	unknown	gnl|CDD|227111
NZ_CP016793.1|WP_065917314.1|5209470_5211447_+|intein-containing-Rv2578c-family-radical-SAM-protein	unknown	unknown	gnl|CDD|275263
NZ_CP016793.1|WP_065917322.1|5221426_5222254_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP016793.1|WP_065917321.1|5220272_5221412_+|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl|CDD|224871
NZ_CP016793.1|WP_065917311.1|5206134_5206488_+|DUF1304-domain-containing-protein	unknown	unknown	gnl|CDD|377753
NZ_CP016793.1|WP_065917313.1|5207798_5208860_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|273670

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065917310.1|5205235_5206072_-|fused-MFS/spermidine-synthase	gnl|CDD|223498	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism].	2.72199e-23
NZ_CP016793.1|WP_065917318.1|5215770_5216886_+|acyl-CoA-dehydrogenase-family-protein	gnl|CDD|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	7.52831e-133
NZ_CP016793.1|WP_065917326.1|5226944_5228633_+|hypothetical-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	0.000213506
NZ_CP016793.1|WP_083268872.1|5212579_5213965_+|TIGR03084-family-protein	gnl|CDD|274423	TIGR03084, conserved_hypothetical_protein, TIGR03084 family protein. This family, like pfam07398, belongs to the larger set of probable enzymes modeled by TIGRFAMs family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized. [Hypothetical proteins, Conserved].	8.22795e-99
NZ_CP016793.1|WP_179953699.1|5206408_5207830_-|YibE/F-family-protein	gnl|CDD|377940	pfam07907, YibE_F, YibE/F-like protein. The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE and YibF. Most of the members of this family are annotated as being putative membrane proteins, and in fact the sequences contain a high proportion of hydrophobic residues.	3.10908e-97
NZ_CP016793.1|WP_083268149.1|5224449_5225586_+|S8-family-peptidase	gnl|CDD|173790	cd04077, Peptidases_S8_PCSK9_ProteinaseK_like, Peptidase S8 family domain in ProteinaseK-like proteins. The peptidase S8 or Subtilase clan of proteases have a Asp/His/Ser catalytic triad that is not homologous to trypsin. This CD contains several members of this clan including: PCSK9 (Proprotein convertase subtilisin/kexin type 9), Proteinase_K, Proteinase_T, and other subtilisin-like serine proteases. PCSK9 posttranslationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their degradation. The binding site of PCSK9 has been localized to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR. Characterized Proteinases K are secreted endopeptidases with a high degree of sequence conservation. Proteinases K are not substrate-specific and function in a wide variety of species in different pathways. It can hydrolyze keratin and other proteins with subtilisin-like specificity. The number of calcium-binding motifs found in these differ. Proteinase T is a novel proteinase from the fungus Tritirachium album Limber. The amino acid sequence of proteinase T as deduced from the nucleotide sequence is about 56% identical to that of proteinase K.	6.5689e-119
NZ_CP016793.1|WP_065917319.1|5216885_5218436_+|acyl-CoA-carboxylase-subunit-beta	gnl|CDD|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NZ_CP016793.1|WP_154697493.1|5222181_5223099_-|hypothetical-protein	gnl|CDD|237361	PRK13355, PRK13355, bifunctional HTH-domain containing protein/aminotransferase; Provisional.	0.00409691
NZ_CP016793.1|WP_083268871.1|5208856_5209477_-|nicotinamide-mononucleotide-transporter	gnl|CDD|377432	pfam04973, NMN_transporter, Nicotinamide mononucleotide transporter. Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide.	5.55746e-61
NZ_CP016793.1|WP_065921347.1|5211443_5211971_-|DUF4865-family-protein	gnl|CDD|379781	pfam16157, DUF4865, Domain of unknown function (DUF4865). This family consists of uncharacterized proteins around 180 residues in length and is mainly found in various Bacillus species. Distant homology and fold prediction suggests proteins from this family would have a ferrodoxin dimeric fold and specifically be related to the putative mono-oxygenase ydhR family PF08803, however this prediction has not been verified by experiment.	1.56578e-80
NZ_CP016793.1|WP_065917325.1|5225695_5226874_+|S8-family-peptidase	gnl|CDD|173790	cd04077, Peptidases_S8_PCSK9_ProteinaseK_like, Peptidase S8 family domain in ProteinaseK-like proteins. The peptidase S8 or Subtilase clan of proteases have a Asp/His/Ser catalytic triad that is not homologous to trypsin. This CD contains several members of this clan including: PCSK9 (Proprotein convertase subtilisin/kexin type 9), Proteinase_K, Proteinase_T, and other subtilisin-like serine proteases. PCSK9 posttranslationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their degradation. The binding site of PCSK9 has been localized to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR. Characterized Proteinases K are secreted endopeptidases with a high degree of sequence conservation. Proteinases K are not substrate-specific and function in a wide variety of species in different pathways. It can hydrolyze keratin and other proteins with subtilisin-like specificity. The number of calcium-binding motifs found in these differ. Proteinase T is a novel proteinase from the fungus Tritirachium album Limber. The amino acid sequence of proteinase T as deduced from the nucleotide sequence is about 56% identical to that of proteinase K.	1.71033e-125
NZ_CP016793.1|WP_065917320.1|5218443_5220276_+|ATP-grasp-domain-containing-protein	gnl|CDD|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP016793.1|WP_065917314.1|5209470_5211447_+|intein-containing-Rv2578c-family-radical-SAM-protein	gnl|CDD|275263	TIGR04470, hypothetical_protein_ALIPUT_00462, radical SAM mobile pair protein B. Members of this family are the downstream member (B) of a pair of tandem-encoded radical SAM enzymes. Most of these radical SAM gene pairs have an additional upstream regulatory gene in the MarR family. Examples of high sequence identity (over 96 percent) from cassettes in several Treponema species of the oral cavity to those in multiple Firmicutes in the gut microbiome suggest recent lateral gene transfer, as might be expected for antibiotic resistance genes. The function is unknown.	1.52123e-14
NZ_CP016793.1|WP_065917322.1|5221426_5222254_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	8.60327e-30
NZ_CP016793.1|WP_065917321.1|5220272_5221412_+|acyl-CoA/acyl-ACP-dehydrogenase	gnl|CDD|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	7.57041e-81
NZ_CP016793.1|WP_065917311.1|5206134_5206488_+|DUF1304-domain-containing-protein	gnl|CDD|377753	pfam06993, DUF1304, Protein of unknown function (DUF1304). This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.	3.55968e-35
NZ_CP016793.1|WP_065917313.1|5207798_5208860_-|AAA-family-ATPase	gnl|CDD|273670	TIGR01526, nadR_NMN_Atrans, nicotinamide-nucleotide adenylyltransferase, NadR type. The NadR protein of E. coli and closely related bacteria is both enzyme and regulatory protein. The first 60 or so amino acids, N-terminal to the region covered by this model, is a DNA-binding helix-turn-helix domain (pfam01381) responsible for repressing the nadAB genes of NAD de novo biosynthesis. The NadR homologs in Mycobacterium tuberculosis, Haemophilus influenzae, and others appear to lack the repressor domain. NadR has recently been shown to act as an enzyme of the salvage pathway of NAD biosynthesis, nicotinamide-nucleotide adenylyltransferase; members of this family are presumed to share this activity. E. coli NadR has also been found to regulate the import of its substrate, nicotinamide ribonucleotide, but it is not known if the other members of this model share that activity.	4.99822e-40

Protein sequences

>NZ_CP016793.1|WP_083268872.1|5212579_5213965_+|TIGR03084-family-protein
MRRCDLRTLTSKLDCLFVCRNTRARGDQAAASRPHPRDQAQAHGGNRRVPGRARLVRHHDDGGGRTRRRVPRCAAAPLPDTRRAGGGGGGTRGRGERRGVEAAGGGCREEHARGGGADRGLPRERPVHRGPGAVGGGADGPRAAGAGAGPAGAAGARGLRAGVGAAGRRRHRAGGEGRRAGDAGPGPRPGAGEPARRRRQAACACGALLGEDPGGAAVITELLADLDAESWELDELVARHEDWTVPTPAQGWTVGHQIGHLMWTDKAAILAITDPEAFQAQPLTPDIVDRTAEEAAGLPDLLELWRDSRAKLREHLAAASGKIVWFGPPMSPASMATARIMETWAHGQDVADAFGVTREPTRRIRHVCHIGVRTVGFAFLLNGKAAPEQEIRVELTGPGGELWTWGPQDAENRVTGPALDFAFLVTQRRNREQLKIEATGPVAEEWVPIAQAFAGPPGGGR
>NZ_CP016793.1|WP_065917315.1|5212020_5212380_-|hypothetical-protein
MAHEEAQAQVQDWFTRWDALAVAGEVEKMADMALFPINAVTDGSATSWDRERFLQEMGAQVGGGEVQMESTRTPHFVNDNLVFVITDGTINGVTVRYGDLLVKVGEQWKFQTMVQGGWS
>NZ_CP016793.1|WP_065921347.1|5211443_5211971_-|DUF4865-family-protein
MIAMQYEITLPADYDMEIIRERVRTRGHALDDFEGLGFKAYLTRNTQYAPFYVWNTTEGMANFLYRGGGFQNIIRDFGRPTVMHWPGTAFTRGDAKEAKYATRTITRLAPEANPIDALSDMKLNKTPGLHSAAVGVDPRTWEVVRFELWEEHPGEEGVYEVLHLSAPELDRIGTS
>NZ_CP016793.1|WP_065917314.1|5209470_5211447_+|intein-containing-Rv2578c-family-radical-SAM-protein
MRWDGQKLEAEPQQALPGLPGLVRSVRTPEFADVVFHEVRAKSVLNGVPGSSLPFSWTVNPYRGCSHACTYCMAGDTPILMGDGRTKPLSELRAGDQIYGTELVGNYRRYKLTTVLAQWETEKVGYRLTLEDGTSVVASGDHRFLTDRGWKHVTGETAGTGRRPHLTTGNKLMGTGAFVEQPTVTDDYRRGYLRGMVEDEHEFRIPLADIEAMDRTREYLDYFGVREGRGFLHQVRELAHWQIAPNPDWLKGFLAGAFDYLGTCSRSILRLSTRNATVIEAICLALKHFHFDFAIEELRRRRGVRVVRLRGGLRENLRFFHLVDPAITRKRDIDGVAIKSQQPLGVVSVEQLGEMPLYDITTGTGDFIANGVVSHNCFARKTHSYLDLDTGHDFDNQLIVKVNAGEVLSRQLRAPKWKQEHVALGTNTDPYQRAEGRYALMPGIIEALTASRTPFSILTKGTLLARDLPLLVAASEVVPVGIAVSLALLDRDLHRSLEPGTPTPAARLDLVRKVREAGLPCGVFVAPVLPELTDSVEQLDFLLEQIADAGATGVTVLPLHLRPGAREWFAAWLRREHPDLIETYRHLYGNGSYVDRGYRRRLAARVTPLIEKHGLAPRGRPAEAVTGVPGDDEGVWPDGSLPIGVPAPRVDQEQLTLL
>NZ_CP016793.1|WP_083268871.1|5208856_5209477_-|nicotinamide-mononucleotide-transporter
MAHLDSNTCSNTGQGEHVSPIEVAGFVTGALCVWLVARQNPWNWPIGIANNIAFLVLFWGSGLYADSGLQVVYMVLAVYGWWAWVRGGEQHSTLKVGRTTTNQWITLAVTGVAGTALLHWILISFTQSTVPFWDAITTVLSLLATWGQARKKVECWWLWIAADVIYVPLYAYKELYLTAVLYVGFMVLCVIGLRNWTKDLKDEVRV
>NZ_CP016793.1|WP_065917313.1|5207798_5208860_-|AAA-family-ATPase
MKEFDHALVLGKFYPPHNGHHHLIETAAARSTRTTVTVLAASTEAIPLAHRVEWLAEHHRYTDGVRVVGDLDDHPMDFDDDHIWSLHVELTKAVLARRAIADGEPHRAPVDVVFSSEKYGDELARRLGAEHVLVDLDRTTHAVSGTAVRTDPVAHWHHLSPATQRGLARRVVVLGAESTGTTTLSKQLAAHFGAPWIPEYGREHTEHKLKAAQAFDATATVDGLVWTLGDFEDVAREQERRLWAETAPLVVADNDAFAATVWGERYLGFRPEVHQGTEPHLYLLTDHLGVPFEQDGWRDGEHLREWMTGLFERELAQRGVPWVKLTENRFATAVTEVERLMRQDVTRGSRSRA
>NZ_CP016793.1|WP_179953699.1|5206408_5207830_-|YibE/F-family-protein
MSRVGHGHGHSHSAAEPASQRVRTLLTWLLVPLVLATVAGAVLLYPFGHEQRTGAQVGLHQKPVNAVVTGVQDGVCGENCTSVTVKMSDGDANGQSVTIPTLRGPGAPRYQTGDEVVLSYSGSQPQAAESYQIVDYQRGWSLALLAVLFAAAVLLLGRWKGLAALGALLLSFVVLVLFVLPAILAGENPLMVAVVGAGLIMFVVLYLSHGVSARTSTAVLGTLVSLVLIGVLGAVFSWASRLTGLDEDTINLVTVLGTDIDTRGLLLAGTIIGALGVLDDVTVTQTSAVWELRRANEKLTWGELFAAGSRIGRDHMSSVVNTLVMAYAGAALPLLLAISLAGRSMGEILTAQQIAQEIVRTLVGSIGLVAAVPVTTALAALVAVRQEVTPVAAPDPEPEPEPEPEPKTVKRAKPAVEPAAKPAAKPARTRIEGDLYGYDPDKGPWVRPSERAARRAAPARPAPPARRRSSGSP
>NZ_CP016793.1|WP_065917311.1|5206134_5206488_+|DUF1304-domain-containing-protein
MQVIANILIALVALIHIYIVVLEMFLWTTPRGQKAFGITAEFAEQSKALAANQGLYNGFLAAGLVYALIRQDFGASVLFTVFVIVAGIYGTFTASRKIFFVQVVPGALALLFVLLAH
>NZ_CP016793.1|WP_065917310.1|5205235_5206072_-|fused-MFS/spermidine-synthase
MGRQRPEAEAITESIDSGVAELVPEVGSRSSWTLRVNGTPQSHVDLDDPTYLEFEYVRRLGHVVDLVAPARVLHLGGGALTLARYVAATVPRSTQQVAEIDAGLIAFIRRELPPPPRVKITTGDARAVLARTRPGSFDLIVSDCFAGARTPAHLTSVEYVRQASDALAGDGVYAANIGDGNGLQFARSQCATVRAVFEHVCVLAEPGVFRGRRFGNLVIFASHTGLPMQQLTRATASDPFQGRVEHGTGLTKFIGGAPVTTDETATLSPAPPSGLWGT
>NZ_CP016793.1|WP_065917309.1|5204407_5205037_+|hypothetical-protein
MSSDDKLSLDLLDKVTVRKRARMVAIGGFMVALAFGAIVGFIGGRWAGVITFLIVSLPVVLLAMSEARRTVWLEGSAVNVRAFGTRTVDLFTADGLDLLVTDLRGARTVGLFVRGNKKAINVALSMYSGVGGRELGIYQLRRLADTLAGRGDTPGLVFSELLVAQLRAEARGVAPAERPLYRLGSLAPAGRMAQKLHPDAVSKFVTSLD
>NZ_CP016793.1|WP_065917318.1|5215770_5216886_+|acyl-CoA-dehydrogenase-family-protein
MIAKDLFDEREELRSLVRNFTCKEIVPHLAEWERAGEVPRELHKKAAGIGLLGIGFEHGDLIDSVVVTEEVIQAGGSSGVIAALLTLGIAIPHIWQSGNQDLIDRFAKPAIGGEKIGSLAVTEPGAGSDVAAITTKATKQGDHYVVNGAKTFITSGCRADFVTTAVRTGEPGYQGISLLVIEDGFTRRKLDKMGWHCSDTAELHFDDVKVPAKNLVGEENQGFVQIMRQFQVERITLAAQAYATAQRALDLTVGWVRNRETFGKPLVKRQVVSHRLAEMAMKIDLARTYTRETAIRINRGEDCVTEVCFAKNAAVETCAEVVDAAVQLHGGMGYMRESEVERHYRDARILGIGGGASEVMTELAARRLGFA
>NZ_CP016793.1|WP_065917319.1|5216885_5218436_+|acyl-CoA-carboxylase-subunit-beta
MGNREALLAKIAQLDAEHEKALAGGGPKYVERHHKRGKLLARERVELLVDEDSPFLELSALAAWGTDFPVGASVVTGIGRIEGVECVIVANDPTVRGGSSNPYTLRKSLRANDIALQNRLPLVSLVESGGADLPTQSEIFIPGGRAFRDLTRLSAAGIPTITAVFGNATAGGAYVPGMSDHVIMIKDRSKVFLGGPPLVKMATGEDADDESLGGATMHGTTSGLADFVAEDETDAIRLARRVVANLNWRKQGPRPHEPEEPRFSQDSLLDIVSEDQRVPFDPRDVIARLVDASRFDEFKPLYGTSLVTGWARIHGYPVGILANARGVLFSEESQKATQFIQLANQSDTPLVFLQNTTGYMVGAQYEQGGIVKHGSMMINAVSNSKVPHLTITMGASYGAGNYGMCGRAYDPRFLFTWPNAKSAVMGPAQLAGVLSIVGRQAAIAKGQEYNEEHDAAMRKMVEAQIEEQSLAPFLSGKLYDDGVIDPRDTRTVLALCLSAVHSGPIEGADGFGVFRM
>NZ_CP016793.1|WP_065917320.1|5218443_5220276_+|ATP-grasp-domain-containing-protein
MIKTLLIANRGEIARRIIRTCKANGIRTVAVFSDPDATAPHVREADFAVHLPGASPTDTYLRADLLVEAARTAGADAVHPGYGFLSENAGFARAVETAGLTWVGPAPDAIEAMGSKVAAKKRMAAAGVPTLPELDPDTVTEFPVLIKASAGGGGRGMRVVREKAEFHDALASARREAESAFGDPTVFCEPLLEHARHVEVQILADTHGTVWALGERECSIQRRHQKIVEESPSPAVDDEIRERLFAAAVAAAGSIGYVGAGTVEFMLKGTDFHFLEVNTRLQVEHPVTELVHGVDLVEWQLRIAEGARLPEEPPRPRGHAIEVRLYAEDPAHDWRPASGTLHRFHVPGDVRLDSGVEDGSEVSVHYDPMLAKVVAHAPTRRAAARKLATALADARIHGLVTNRRLLVDVLEHDAFLDGDTHTGFLTEHDLTRTVDPQPFALAAALANAATRRIGHLPLGWRNVRSQRPKAKFLHGDELIEVEYDPRQATENTVVLDLDGVRVPFHVARYDDLVEVDSPRGSLTLRVVPRFPEPQTKLAPGATVAPMPGTVVRVSVEQGQQVEAGAELLVLEAMKMEHRVLATNAGTVAELLVERAQQVNAGDVLAVVEES
>NZ_CP016793.1|WP_065917321.1|5220272_5221412_+|acyl-CoA/acyl-ACP-dehydrogenase
MSFVESQERIALRRAVAELGAKYGNEYFAAKARAGEKTTELWQEAGKLGYLGVAVPEEYGGGGGGIGDLAAVCEELAAAGCPLLLMVVSPAICATVIARFGTAEQKSKWLPGFADGTLKMAFAITEPDAGSNAHKLKTTVRRDGDEWVLNGSKTYISGIDEVDAVLVVSIQATGPVLVVVPTNAEGFTHHEIEMDLLSPEKQFTLFFDDVRLPADAVVGSPDQGLLQVFAGLNPERIMGASMATGSARLAVGKAVTYAKQRQVWDTPIGAHQGLAHPLAKIHIEIELARLMTQKAAALYDGGRDKEAGEAANMAKYAAGEAVAAAVDQAIQTHGGNGLTAEFGLASMLGMSRLSRIAPVSREMVLNFVAQNSLKLPRSY
>NZ_CP016793.1|WP_065917322.1|5221426_5222254_+|alpha/beta-hydrolase
MGTFTTSDGTTLAYHSAGGSNPLVCLPGGPMQNASYLGDLGGLPDTLVLDLRGTGASQEADPRTYRADRQVDDVEALRQHLGLDRISVLGHSAGGTLAVLYAQRYPQHVEHLVLVAPSPRVVGIDVTDADRRAVAEQRRGEPWFAEAFAAFEDIWAGNATEENFARIAPFSYGRWDDEARALDEHPRNDEGARQFYAEGALDPEQTRKALATLDAPTLLLAGEYDVALPPDRAREYAALFRDAELVVQPGAGHFPFVDDRVAFTAAVTGMLQRIP
>NZ_CP016793.1|WP_154697493.1|5222181_5223099_-|hypothetical-protein
MLAIYPPREELADLLVTGPFADALRVAIQVRGLSLERLQHRLRVRGAPISVTALSYWQSGRRRPERPESLRALAHLEDVLGLPDTALSRLLGPPRPRGRSRRREAPPRSPWDGSGLVLTAQHDRVDVASCGGVRGIRTRQVVQATAAGVDRWILCQETGSAQPAVTAIRSCRVGRVARERTNGVLVAELMFEEPLSPDESVAIEYELIYPSPTAEHTHFRRFGERVHDYVLEIKFPLDAPPVSCERFATGPAGAEMSGGARQEPVDAWGYAHTAALDFGPGLYGMRWSMPVTAAVNATRSSTNGK
>NZ_CP016793.1|WP_083268149.1|5224449_5225586_+|S8-family-peptidase
MCGPGSAQSRGRSLQRKGSLPVRALLAVAALAAAVVVAPASAATSSYIVVLKDGAVASSAGTVEHRYTSVFNGYSARLTARQLRTVQADPNVSYVERDGIVHASGTQLNPPWGLDRIDQRALPLDQRYEYTSTGAGVNIYVIDTGLRVTHTDFGGRARNGWDTVDNDAVAQDDNGHGTHVAGIAAGTKHGVAKRATVWGVRVLNGSGSGTISGVIAGVDWVARNAVKPAVANMSLGGGASTALDDAVRRAIAAGVSFTVAAGGSNTDPANSSPQRVSQAICVGASTQADTKSSSSNHGPLVDIWAPGVGIPSAWNTGDTATATLSGSSMAAPHAAGVAARYLQFNNAATPAQVEHALVTTGTPGTPPVTRLLHWPPSL
>NZ_CP016793.1|WP_065917325.1|5225695_5226874_+|S8-family-peptidase
MHTMTRKIRFLAGAGVATLAMSVLMVPSASAAEGQVLEADAAEKVSGSFIVKLKEGKASAQSLASRFGAKVERNYATFGGFNVKLSEKQARILAADPSVEYVEQDQVFHVQATQTNPPSWGLDRIDQRNLPLNSSYSYTSTGSGVSAYVVDTGVRISHSTFGGRAVNGYDAVDNDNVAQDGHGHGTHVAGTIAGSQYGVAKAARVVAVRVLNNSGSGTTAQVVAGIDWVGNNAVKPAVANLSLGGGVSTAIDNATRSAIAKGVTFAVAAGNSNANASGFSPARVAEAITVGATDRNDARASYSNFGAVLDIFAPGSSITSSWSTSDTATSTISGTSMATPHVAGAAARYLSTNRAATPAQVASYLVAQSTPSKVTNPGSGSPNRLLYLAPTA
>NZ_CP016793.1|WP_065917326.1|5226944_5228633_+|hypothetical-protein
MLDELETIPWERLEHNRGTAENVPELLRAARTSVEPWAELDDCLFHQGGWVCPAARAALPFTVELASSASVPGRVSSLRLIGHIAEVAGVAEAEFVDDGWPAEWARALPRLVDLAADPDPGVRSGALWALGCGGGPVAPGLVARWDVETDPAVRLDLVLTLGKLAPQWVRELRGDDPQVRLAAACASGSPAVEEFLPGLRADLSVWSGTVWVGGPARVLGLVREALEDRPAEHAAVLTGFEPADDELRRGQLTALGELLTRWRSPVATVLPLLGERLRDPSARVRWTALHLLGSVRAAGYADDVAALLEDETPVGRQRQFVGDAAAWALTRFGRPVPDLVARLDRFGDVEQFFSAAVYVPWLPAAHEVLQPLRDFGLVPAVLDRLAAASGFRRTNFIALLGSWGVPEAAPVLSELAAGEPVAAWAWWRCGGPAELIAAAKVTHQTVKWLGDIGSTAAAHVSLLPLDEPDDWMRVATRRARWRMTGEVGDLVPVCTEVLSGLDDGRFLPVMVPAAQALAEVGERPEVLVRALASDRRWASSGGWRAFDQDERLRAVLEDPIRD
>NZ_CP016793.1|WP_065917327.1|5228609_5228897_-|hypothetical-protein
MRIVVALLGMLVLFGAAVFVMFFGILGFTPTTTCSGTCQVPLVLSFVAPVVFGLAATFATWFRALQRPRAYWPWLGAALILGTYLVSLSVADRVL

Crispr_ID: NZ_CP016793_11

• CRISPR_ID: NZ_CP016793_11
• CRISPR_location: 5939021-5939115
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016793_11

Consensus_repeat	Method
TTCGCGGGCATCCCGGTCGGCACCGA	CRISPRCasFinder

spacers of NZ_CP016793_11

>11.1|5939047|43|NZ_CP016793|CRISPRCasFinder
GACGCCCGCCCGGTCCTCGTACGAGTCCGAGCCGCGGGCGACC

CRISPR arrays and Neighbor proteins around NZ_CP016793_11

CRISPR arrays

The CRISPR arrays of NZ_CP016793_11

>merge|NZ_CP016793|11|5939021-5939115|CRISPRCasFinder
TTCGCGGGCATCCCGGTCGGCACCGAGACGCCCGCCCGGTCCTCGTACGAGTCCGAGCCGCGGGCGACCTTCGCGGGCATCCCGGTCGACACCGA

>NZ_CP016793|11|9|5939021-5939115|CRISPRCasFinder
TTCGCGGGCATCCCGGTCGGCACCGA	GACGCCCGCCCGGTCCTCGTACGAGTCCGAGCCGCGGGCGACC
TTCGCGGGCATCCCGGTCGACACCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_065917844.1|5936486_5937173_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065921435.1|5927048_5928320_+|alpha/beta-hydrolase	unknown	unknown	unknown
NZ_CP016793.1|WP_065917847.1|5942052_5943042_+|DJ-1/PfpI-family-protein	unknown	unknown	gnl|CDD|227311
NZ_CP016793.1|WP_065917837.1|5925645_5926812_-|histidinol-phosphate-aminotransferase-family-protein	unknown	unknown	gnl|CDD|223157
NZ_CP016793.1|WP_083268218.1|5940078_5940927_+|carboxylesterase-family-protein	unknown	unknown	gnl|CDD|365897
NZ_CP016793.1|WP_065917842.1|5935461_5936022_-|DivIVA-domain-containing-protein	unknown	unknown	gnl|CDD|377456
NZ_CP016793.1|WP_065917846.1|5940910_5941915_-|hypothetical-protein	unknown	unknown	gnl|CDD|238861
NZ_CP016793.1|WP_065917839.1|5931935_5934416_+|DNA-topoisomerase-IV-subunit-A	unknown	unknown	gnl|CDD|235503
NZ_CP016793.1|WP_065917843.1|5936070_5936490_+|zinc-binding-protein	unknown	unknown	gnl|CDD|225557
NZ_CP016793.1|WP_065917836.1|5924023_5925622_-|DUF4331-domain-containing-protein	unknown	unknown	gnl|CDD|379511
NZ_CP016793.1|WP_154697574.1|5946351_5947449_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065917848.1|5943041_5943662_+|DJ-1/PfpI-family-protein	unknown	unknown	gnl|CDD|153233
NZ_CP016793.1|WP_083268892.1|5944407_5944950_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213222
NZ_CP016793.1|WP_154698038.1|5943790_5944408_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213222
NZ_CP016793.1|WP_065917851.1|5948465_5949458_-|proline-racemase-family-protein	unknown	unknown	gnl|CDD|368491
NZ_CP016793.1|WP_065917838.1|5928397_5931904_+|DNA-topoisomerase	unknown	unknown	gnl|CDD|235501
NZ_CP016793.1|WP_065917850.1|5947596_5948448_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065917841.1|5934942_5935317_-|RlpA-like-double-psi-beta-barrel-domain-containing-protein	unknown	unknown	gnl|CDD|367450
NZ_CP016793.1|WP_170067979.1|5945003_5945996_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065917840.1|5934416_5934932_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|224584

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065917847.1|5942052_5943042_+|DJ-1/PfpI-family-protein	gnl|CDD|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	6.53728e-80
NZ_CP016793.1|WP_065917837.1|5925645_5926812_-|histidinol-phosphate-aminotransferase-family-protein	gnl|CDD|223157	COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism].	9.04292e-67
NZ_CP016793.1|WP_083268218.1|5940078_5940927_+|carboxylesterase-family-protein	gnl|CDD|365897	pfam00135, COesterase, Carboxylesterase family.	2.10815e-50
NZ_CP016793.1|WP_065917842.1|5935461_5936022_-|DivIVA-domain-containing-protein	gnl|CDD|377456	pfam05103, DivIVA, DivIVA protein. The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype. These proteins appear to contain coiled-coils.	7.47806e-06
NZ_CP016793.1|WP_065917846.1|5940910_5941915_-|hypothetical-protein	gnl|CDD|238861	cd01823, SEST_like, SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxylic acid.	1.28856e-22
NZ_CP016793.1|WP_065917839.1|5931935_5934416_+|DNA-topoisomerase-IV-subunit-A	gnl|CDD|235503	PRK05561, PRK05561, DNA topoisomerase 4 subunit A.	0
NZ_CP016793.1|WP_065917843.1|5936070_5936490_+|zinc-binding-protein	gnl|CDD|225557	COG3012, COG3012, Uncharacterized protein conserved in bacteria [Function unknown].	8.69879e-42
NZ_CP016793.1|WP_065917836.1|5924023_5925622_-|DUF4331-domain-containing-protein	gnl|CDD|379511	pfam14224, DUF4331, Domain of unknown function (DUF4331). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 223 and 526 amino acids in length. There is a conserved FPY sequence motif.	0
NZ_CP016793.1|WP_065917848.1|5943041_5943662_+|DJ-1/PfpI-family-protein	gnl|CDD|153233	cd03139, GATase1_PfpI_2, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	2.03321e-63
NZ_CP016793.1|WP_083268892.1|5944407_5944950_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.07189e-52
NZ_CP016793.1|WP_154698038.1|5943790_5944408_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.68179e-55
NZ_CP016793.1|WP_065917851.1|5948465_5949458_-|proline-racemase-family-protein	gnl|CDD|368491	pfam05544, Pro_racemase, Proline racemase. This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Trypanosoma cruzi PA45-A, a protein with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.	4.23238e-152
NZ_CP016793.1|WP_065917838.1|5928397_5931904_+|DNA-topoisomerase	gnl|CDD|235501	PRK05559, PRK05559, DNA topoisomerase IV subunit B; Reviewed.	2.96831e-164
NZ_CP016793.1|WP_065917841.1|5934942_5935317_-|RlpA-like-double-psi-beta-barrel-domain-containing-protein	gnl|CDD|367450	pfam03330, DPBB_1, Lytic transglycolase. Rare lipoprotein A (RlpA) contains a conserved region that has the double-psi beta-barrel (DPBB) fold. The function of RlpA is not well understood, but it has been shown to act as a prc mutant suppressor in Escherichia coli. The DPBB fold is often an enzymatic domain. The members of this family are quite diverse, and if catalytic this family may contain several different functions. Another example of this domain is found in the N-terminus of pollen allergen. Recent studies show that the full-length RlpA protein from Pseudomonas Aeruginosa is an outer membrane protein that is a lytic transglycolase with specificity for peptidoglycan lacking stem peptides. Residue D157 in UniProtKB:Q9X6V6 is critical for lytic activity.	1.40598e-12
NZ_CP016793.1|WP_065917840.1|5934416_5934932_+|GNAT-family-N-acetyltransferase	gnl|CDD|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	4.10311e-11

Protein sequences

>NZ_CP016793.1|WP_065917844.1|5936486_5937173_+|hypothetical-protein
MNPDVTTVKIESRFNGPPGMGNGGYVSGRLAAHVGTGPVRVRLRKPVPLDREMQVSGGELLDGDVVIASAEPAELDLEVPAAPSIDEARAASAEVPWRDRHPFPTCFGCGPGREDGIGAARAAGGAWEWAGVWRPTAVLPHDGGSVLPEVVWAALDCPSAQPVAPDGGPAFVLGTFVAQVEQPVALDVDHVLLAWELGREGRKAYSASAIIGPHGVCGRATAVWVSIG
>NZ_CP016793.1|WP_065917843.1|5936070_5936490_+|zinc-binding-protein
MRCDIGSNGFTRHNVDVTTKLCPCGTGQSYVDCCGALHSGARTAATAEQLMRSRYSAFAVSDEDYLLRTWHSRYRPESAGTADNDRWLKLEILDTENGGLLQTEGVVEFRAHYVGGVVHERSRFARENGQWVYLEGDQK
>NZ_CP016793.1|WP_065917842.1|5935461_5936022_-|DivIVA-domain-containing-protein
MTVESRVDLVPLRTWFGLRWRGYDRDEVDDYVAELESELRLVTADRDASEARADALASRLMSVQEENDALRDGLHRICLTPIDPKGLPERLARMVALAEEERREVIRDAQLKALMIVGEAEARARALDEGAAAKREEVREDFRLAMSARRAEAMRALAELRNVALDEAERIIAEAKVRRAGIEQDT
>NZ_CP016793.1|WP_065917841.1|5934942_5935317_-|RlpA-like-double-psi-beta-barrel-domain-containing-protein
MRVTALLMTLITALLSGTGTAAAVTGKATYYNDRGYGACGTQIDASTQLLVAVPKGLWTTPNPNNDPLCTKQVRVTYNGRTITVPVKDKCFGCDNTHIDLSEPAFRQLGDPNAGVLQPVTWQIV
>NZ_CP016793.1|WP_065917840.1|5934416_5934932_+|GNAT-family-N-acetyltransferase
MFRRVEAGEGEALADFLAGEPWPFHVHTAVERADVLERVKAGYYDETYWIEVAGERAGIVRLFDLQDETPMFDLRVSERHRGRGLGRAAVRWLTDEVFGEHPHVERIEATTRQDNLAMRRVLKQCGYVKEAHYRRAWPDGDGRRLDSVGYAVIRHDWQTGETTVPDFHDED
>NZ_CP016793.1|WP_065917839.1|5931935_5934416_+|DNA-topoisomerase-IV-subunit-A
MARRKGTTTKVDPAAFDRAGAQVLDNSLKTEIEDSYLEYAYSVIHSRALPDARDGLKPVHRRILYSMNQNGQRPNTPYVKSSRVVGDTMGRYHPHGDTAIYDALVRLAQDFSLNEPLIDGHGNFGSPDDGPAASRYTECRMSPVAMQLVGELNEETVDFRPNYDGSLEEPSVLPAAFPNLLVNGTSGIAVGMATNMIPHNLREVVGAARWLITHPNADLDKLMEFVPGPDLPTGGLLLGLDEVRKAYETGRGVVRMRAKVEIGPLEGSRGRQAITVTELPYGVGAERIVEKITDEVNKSKRLTGIADVKDLTDRENGIRLVIECKVGVNPQALLADLYRLTPMEQSFGINNLVLVDGQPRTLGLKELLEVFLRHRYDVVTRRTKFRRRKREERLHLVEGLLKALLDIDKVIRLIRGSDNAAAAKDGLMKQFRLSEIQASYILDTPLRRLTKYDKIELEGEQDKLTEEIAELTTILEDEGVLKKLVSAELAAVTKELGGERRTSLIDGDLKEVLAASKPAGPLEVADDPCQVILSATGLVARTAAESEEASEGKRRAGRVKHDAVSALVHSTARGQVVLVTNLGRAFKTDVLPLPVLPEQSGTVSLRGGMAASELVPLEKGEKVVGIAPLDPKDSPGIALGTKLGTVKICSPEWPVRSDEFEVITLKDGDEVVGATWLDDGTETLAFVSSDSSLLRYDAKLVRPQGLKGGGMAGINLSGDAHVVFFGAIKTNDDKHGEPMVVTSSGQSVKVTPFSEYPAKGRATGGVRSQRFLKGETHLVVAWIGSRPAGADDKGSPVELPEIDPRRDGSGHLHPGPDVVGHLIERD
>NZ_CP016793.1|WP_065917838.1|5928397_5931904_+|DNA-topoisomerase
MTAETLYGADDLTHLEGLEAVRKRPGMYIGSTDSRGINHLFSEIVDNSTDEGVAGHASKVVVTLHADGSVQVDDDGRGIPTDVHAKSGLSGVELVLTKLHAGGKFGGSGYKTSGGLHGVGASAVNALSLRYDVTVRRGGKVHSMSFAHGVPAVFDGPGPKAKFTRQAGLNVVGKMKRNESTGTSTRYWHDARYFENGATLDVEAVRQKLRNTAFLVPGVTYVLRTALEDTISEEVFHYPNGLTDMVEFLAPTGDRAVSGTLVITGTGTYYENAADENGVMRSKVERQAEVEVALRWGTGYERTVECFTNTIRNVHGGTHRRGFDRAVLKAVQDAISKTRGLLKPKEDPPTLDDVLEGMTAVVHVRIPEPQFTSQTKDELSTAGITKVLQGIVDQQVRAWTEDRKTKTEAKTVLQKVVDASRVRLTQKQQKDAARRKTALEGAAMPAKLVDCRTTGVSRSELFLVEGDSALGCFVGETQVALASGKSLSFLELVEDWQRGVTHFGYATNKAGRVVVVPLVEPRLTKKDAPLVRVTLDDGESVRCTPDHLFRLRDGSYRRADALQPGDSLMPLYRSVSSKAEGHNLDGYERVWMNDRQEWVYTHYLADAYNLRHGLDQAANGNVRHHVDVNKRNKDPRNLKRMTWEDHAALHAAMMGPHVHEGYRAWLAAGGTEFKSAMLSEQWKDQEFRASCLARLAARNQDPAFRERIDQGFQNWYTSLSEDEKAAYAERMRALQAEYWAKPEHRAAAAERVRAFFAQPGKREEWRERSLAQWQDEELLAWRSRTSTEQFADPAERQRQRDAVVAWRENNPEFGREHSARMKQRMADESTGHLEKVQAGRRRYVESTSREERVAKQREGRRIAALKRLAPMLELKSDFELALSYELDRRQNAKTGLRFLNVLAHYDDDFARLREAATMVNHTVASVEALPEREDVYDLTVDGYHNFALEAGVFVHNSARMARVSEYQALLPLRGKILNVQKASLADTLRNAEIASIVQVLGAGTGRTFDISQMRYGRVILMADADVDGSHIRTLLITLFAKYMRPVIEDGRLYAAMPPLHKVMTRGRNPETHFTFTQRQMEQKVAQLEKAGKQVVTPVPRFKGLGEMDADELWETTMNPATRSVRRITMDDVEAAEIALELLMGEKVEPRRNWLVESAARVDQSAIDL
>NZ_CP016793.1|WP_065921435.1|5927048_5928320_+|alpha/beta-hydrolase
MPAEASGLTVHTGQIDGAEYRVEVPSRWNGTLLLYSHGTYPAGYTPPIEMASRPAARDELLRRGYALAASRYRVPHGHSVPDALRDQPALADWFAREVARPRRVIAWGASLGGLTSVMLGERQRFDGVLALCGALRGAVTRSNQLLDLGFVLRTFFEPSLQVARVSDAAANEQRAVAAVDNALTTARGRARLALANAVAGIPAWSRVHEPRPVAVEEAVRQAAVHDRTLARSLAWGTGRVDIETRAGGNPSWNTGVDYRVLLQRSAQRQLVLDAYDEAGTSPAEDLAALAAAPRVAADAPAVRWLHEYGDPNGHAKAPVVTLHALGDPTGVEHSGAYAGRDVRQLFVNRAGHCMHTAAEELVALELLQDRISTGRWPARDLNAAAAQHGPEMRVLQDWTTTPPREETVAPGFVTHHPGPFPRP
>NZ_CP016793.1|WP_065917837.1|5925645_5926812_-|histidinol-phosphate-aminotransferase-family-protein
MRHGVDSGLFQQTAHSPSYFELARTGAADLVDFCIPCNPYFPTPQMFEELSKNLEAVLKFYPSDASKIASQLSTVLGLNPATIAMSNGSTELITWMDHMWIHDSIAIPIPTFGRWTDQPMESNKRVDMFLLQESNNFELDVDEYIKFIRARGSRVAVICNPNNPDGGYLPRREIVRFMDELADLDLVVVDESFIDFVEVERNPSVAAEASIRPNVVVLKSLGKNFGLHGIRFGYLVANPGLAGKMRRTLPKWNLNSLAETVVFMLAEHEGEYAESLRLLSRDRYRMGMELSRIPDLTVYSSQANFLLVRLGGGVDGRELRDHLLSRHQVFIRECGNKLGMSSRFARLVVRPESDVDRLVEGIRDFTQARWTSDHSAHSSEPSLLMHSA
>NZ_CP016793.1|WP_065917836.1|5924023_5925622_-|DUF4331-domain-containing-protein
MSSPHVLSGRRGQVAAAALVAATLLNAAMFGGTGATASSHREAPLIAGDPAVDNTDLYAFVSPDHQDTVTLVGNWFPFQEPNGGPNFYPWAQDAQYDFNIDNDGDAKADIVLRWQFHTDDRRKNNTFLYTNGAVDSLDDENLLFRQRYDIEAIYENGQKVKLVSNAPVAPSPNGPASMPDFKKLRDQATVAIPGGGKVYVGPAEDSFFLDLRVFDLLYGGNLSEVGQDTLRGYNVNTIAIQLPKQALALKNDANRNPNIGIWSTTQRRTMKLSPGKAEAVGDFVQVSRLGNPLVNEVVAPAGLKDAFNGLRPDQDAGVKELVDRVVNPELPKLVEAIYKIPAPQGQRDDLAEIFLTGISTKIGAQINADLNSQINNADVDKNKFRPAEMLRLNMSIAPNANPNRLGLLGGDTQGFPNGRRLTDDVIDIGLQAFEGAAASGKLVEALAAGDKVDQNDQAFEAAFPYVALPRNGAAVNASGNTAEVAVAPVGRIGNLDPMAMTTAVGSALVFGAGFFLWRKRQAHIRKYGSHSK
>NZ_CP016793.1|WP_083268218.1|5940078_5940927_+|carboxylesterase-family-protein
MTAFLGVRYAEPAVGPLRLSPPVDCDGEPAGEFGDRHTLNVWSTSDSAAPVLLWVHGGANTVGSAAQPEYAGDVLAELGVVFVSCDYRLAEDGYGAVEGFPHNRGLLDVVSALRWIQRNIAAYGGDPGNVTVAGQSSGAQAVASLMVMPAAKGLFHKAIAHSLAGRFFTPEEAARIQREKPADVVLYQPIIDGGTVPRSPLEGPYDVDLLVCHTADEDEELFQRPTMRFADAANAYRSVYARTPAHHGADVPAMFRGDIARAWARFAHTGDPGWPREVSFRW
>NZ_CP016793.1|WP_065917846.1|5940910_5941915_-|hypothetical-protein
MRRVLPLMAIVVLTILLVVSDHPFPPPSDPDRESRTAVVALGDSTLSGEGAGSYEPGTNGEDGGTWCHRSSEASIMKARVEADERFNLACSGANSDKLRNEQLPQLRRIAGSHRVVALVVAIGANDDPKFADILNTCVQAWGARNDCTSKVAPEWTKRVTRMVPKVENTLNAIRQTMRDSGYLDSSYQLVLQSYAAPVAPDMPRSLQNLSGCPLRTSDLRWVVDEGVPELSNGLRAAAGKAGARFLDLARAGEGHEACVGGSSPDDEWFTRLTLDWAGLKDDRRSAHALQESFHPNARGHQQFANCLSEFLAVDKGDGACVPRLDGTLGLTTEN
>NZ_CP016793.1|WP_065917847.1|5942052_5943042_+|DJ-1/PfpI-family-protein
MGRDEESGGVGNLREIVVVGYDRTALLDLAGPIEVFQAANHGDQRYRVTVATLGGEPFTATAGVRIEAGADLRTLDRPIDTLLVVGGWGYDEAATDPVLTTNLRRLALKSRRVAGVCTGAVVLAGAGLLTGKKATTHWAFTGELEARGVDVEPDAIFVCDGQVATSAGVTAGIDLSLAMVEQDHGPALARRIAQYLVVFLQRSGGQSQFSVHTRTPPVSDDALRALLDAIHADPTREWTVPVMARRAMMSVRHFARVFSRNVGISPAQYVERARVEAAADRLASTGDGLDLVARQSGFGSAETLRRAFLRVLGVSPGSYRARFRTTGVA
>NZ_CP016793.1|WP_065917848.1|5943041_5943662_+|DJ-1/PfpI-family-protein
MDVAYVLYPNMTALDLVGPFEVLGCVPVVSPRFVARTLDPVRSDNGLTVVPTDTFDTLKSADVVVVPGSGHWREVLRESAELVAWLREVHPTTKWTTSVCTGSTLLAEAGVVTKATTHWAAREDLTVRGVEACTDRVVFDGKVVTGAGVSAGIDMALQLVEREFGTAVAQTVQVGIEYDPQPPHAYDSIPPEVTQNLRSLFAASQS
>NZ_CP016793.1|WP_154698038.1|5943790_5944408_-|ATP-binding-cassette-domain-containing-protein
MSAAGVRRSFGGVEVLRGVDLVVAPGEFVTLSGPSGSGKTALLSILCGFDFPDAGAVEPGPAAWSACAVLPQSLGLATELTLEENVALPLRLRGLATDPVARVLAELGIGDLGGRYPAQVSFGQQQRAALARAVVARPSALLADEPTAHLDAASAEAAIGVLRRVADDGAAVLIATHHDAVHAAADRVLELAGGRISSGLRRTTT
>NZ_CP016793.1|WP_083268892.1|5944407_5944950_-|ATP-binding-cassette-domain-containing-protein
MSLGIAAGLTVLSGPSGSGKSTLLRVLSLVERPSAGEVYVRDRPTSGLSWKELRSLRRKEIAVVFQNPADNLIGHLTVGENLRAAGATDLSLLEQLGLGDSATWRIGALSGGQQQRLAFGCALARGASVVVADEPTSQLDVRSADLVLETLRTLPVPAVVASHDPRLVELADLCVPLVAS
>NZ_CP016793.1|WP_170067979.1|5945003_5945996_-|hypothetical-protein
MGVLAVGTVAVGSSVAGAQQSALDSKSGVYVGANSTAQVSQDVATGKVALPEALRGNTTVVGVSSGALVVEPATFTDAAIVADPARVRTVLAGLGKTGAVASAVRIGRSANQEMQIPGLPLLKPTEQLPSFPKLGTRGYVVTKDSVPALEQVGSWHLWSSLPLGALTAELQKAGIHHTNVVDRAKVLDGLPFLTVQWTFGFVAAIGVVLAVVAAVALLLAIEVRRRQNAVSGALSTRMGLKPAVLWSSHLLEVGAVALCAVAIGAVASFVSAGAAVPRLDPAPWLNPAPMLPNLVPLLGLMVLCGGVVVAAAAWLAVRGVRNARMGELLR
>NZ_CP016793.1|WP_154697574.1|5946351_5947449_-|hypothetical-protein
MQLPWRAAPRAALSSPLTLLVSIVTTLLLGFVVAAAVLHSSAAGSAALAYQQGRICPQSMHPSLDGDRLPLDTAIRTATANGGLGAVYTNIGRPDFTGLATYGRFGYRPGATEHLKVLQGGGTGLWVPRTIATAAKVKVGDQLVGSSLKVTAIYADLAHPVAGWWCSEAKTVVPNALAGDGTSTSVIWVHQASDLTLLPEDFTAGASVSIRFPVEPVETIAEAEALRDNGNALLAKLGLPLTKTDSISAAITASSTSRDNVGSALLPLVVVSVLVGLAGVGTVTVQWAQRRHSELRLLWVRGAGPLALGVRGVLELGLPLVLGGVLGWWPRGCCCRCTGRARRSRPARCGWRRPRCWPWWCWASR
>NZ_CP016793.1|WP_065917850.1|5947596_5948448_-|hypothetical-protein
MSATPSLEALLRIGPFHAALRAAIRRRGLTLERLRTRLAQQDVAVALSTLSDWQQGRVKPVSPKSLRAVAVLEQLLDVPARSLLGLLEQTGPSGWPEVVPGMMPGFDANDLEIVARHDRVFVDAERHASRALVKMVVRAHTDGVDRYNAHYWGDDEVRVTHEPLRNCRVGQTVLEDRTTVEELLFDRPLRLGETHVFEYLIHDPTRVDSFEYAHGVRCFLAQSLIEVHFDEAALPVDPHVYLQDWEETEPHRTIDLTLDGTNSVHHFESNVSVNWVGIRWSWE
>NZ_CP016793.1|WP_065917851.1|5948465_5949458_-|proline-racemase-family-protein
MRFARYFSAVDSHTEGMPTRVITGGVGVIPGETMADKRLNFVKDHDHVRKLLVNEPRGHAAMSGAILQPPTRPDADWGVLYIEVSGCLPMCGHGTIGVATVLVETGMVEVTEPVTTVRLDTPAGLVLADYDTRTKLVTIRNVPAYAHELDATVTVPGLGEVRYDMAYGGNFYAILPLADLGIPFDRTEKDRVLAAGLSIMDEINRVRRPVHPLDPAISGCKHVQFTAPGLDGADSRNAMAIHPGWFDRSPCGTGTCARMAQLHARGELGIGVEFVNESFIGTRFIGTLLEEVPLGDRTAVVPTVAGRAWITGMGQYLLDPTDPFPEGFSL

Crispr_ID: NZ_CP016793_12

• CRISPR_ID: NZ_CP016793_12
• CRISPR_location: 6299504-6299574
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016793_12

Consensus_repeat	Method
CGGATCGACCAGGGACGCGGGCAGGA	CRISPRCasFinder

spacers of NZ_CP016793_12

>12.1|6299530|19|NZ_CP016793|CRISPRCasFinder
GTCGCGCCGGATCGACCAG

CRISPR arrays and Neighbor proteins around NZ_CP016793_12

CRISPR arrays

The CRISPR arrays of NZ_CP016793_12

>merge|NZ_CP016793|12|6299504-6299574|CRISPRCasFinder
CGGATCGACCAGGGACGCGGGCAGGAGTCGCGCCGGATCGACCAGGGACACGACCAGGGACACGACCAGGA

>NZ_CP016793|12|10|6299504-6299574|CRISPRCasFinder
CGGATCGACCAGGGACGCGGGCAGGA	GTCGCGCCGGATCGACCAG
GGACACGACCAGGGACACGACCAGGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_065918142.1|6308113_6308914_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|366444
NZ_CP016793.1|WP_065918122.1|6291539_6293405_+|polyketide-synthase-dehydratase-domain-containing-protein	unknown	unknown	gnl|CDD|379688
NZ_CP016793.1|WP_065918137.1|6303677_6304895_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NZ_CP016793.1|WP_065918135.1|6301802_6303038_+|VCBS-repeat-containing-protein	unknown	unknown	gnl|CDD|379232
NZ_CP016793.1|WP_083268261.1|6296095_6297355_+|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl|CDD|223733
NZ_CP016793.1|WP_083268263.1|6299741_6300377_-|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
NZ_CP016793.1|WP_065918140.1|6306744_6307533_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_083268262.1|6297385_6298303_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065918130.1|6298538_6298814_+|nitroreductase-family-protein	unknown	unknown	gnl|CDD|380315
NZ_CP016793.1|WP_065918138.1|6304891_6305503_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065918124.1|6293846_6294590_+|SRPBCC-domain-containing-protein	unknown	unknown	gnl|CDD|176856
NZ_CP016793.1|WP_065918126.1|6295484_6295991_-|SRPBCC-family-protein	unknown	unknown	gnl|CDD|176854
NZ_CP016793.1|WP_154697599.1|6298299_6298539_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065918123.1|6293397_6293814_+|acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|238329
NZ_CP016793.1|WP_065918125.1|6294629_6295481_+|SRPBCC-domain-containing-protein	unknown	unknown	gnl|CDD|176856
NZ_CP016793.1|WP_065918141.1|6307646_6308069_-|hypothetical-protein	unknown	unknown	gnl|CDD|366388
NZ_CP016793.1|WP_065918134.1|6301109_6301541_-|ester-cyclase	unknown	unknown	gnl|CDD|377824
NZ_CP016793.1|WP_065918136.1|6303155_6303545_-|VOC-family-protein	unknown	unknown	gnl|CDD|319911
NZ_CP016793.1|WP_065918139.1|6305504_6306698_+|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl|CDD|223733
NZ_CP016793.1|WP_065918131.1|6298801_6299068_+|hypothetical-protein	unknown	unknown	gnl|CDD|380315

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065918122.1|6291539_6293405_+|polyketide-synthase-dehydratase-domain-containing-protein	gnl|CDD|379688	pfam14765, PS-DH, Polyketide synthase dehydratase. This is the dehydratase domain of polyketide synthases. Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and an aspartate from the C-terminal hotdog. Studies have uncovered that a substrate tunnel formed between the DH domains may be essential for loading substrates and unloading products.	1.19757e-27
NZ_CP016793.1|WP_065918137.1|6303677_6304895_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.14892e-82
NZ_CP016793.1|WP_065918135.1|6301802_6303038_+|VCBS-repeat-containing-protein	gnl|CDD|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	7.79318e-10
NZ_CP016793.1|WP_083268261.1|6296095_6297355_+|AarF/ABC1/UbiB-kinase-family-protein	gnl|CDD|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	1.84428e-80
NZ_CP016793.1|WP_083268263.1|6299741_6300377_-|PadR-family-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	9.86352e-12
NZ_CP016793.1|WP_065918130.1|6298538_6298814_+|nitroreductase-family-protein	gnl|CDD|380315	cd02138, TdsD-like, nitroreductase similar to Burkholderia pseudomallei TdsD. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.	1.31862e-20
NZ_CP016793.1|WP_065918124.1|6293846_6294590_+|SRPBCC-domain-containing-protein	gnl|CDD|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	7.41381e-19
NZ_CP016793.1|WP_065918126.1|6295484_6295991_-|SRPBCC-family-protein	gnl|CDD|176854	cd07812, SRPBCC, START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket; they bind diverse ligands. Included in this superfamily are the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), as well as the SRPBCC domains of phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of this superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	6.47355e-16
NZ_CP016793.1|WP_065918142.1|6308113_6308914_-|ABC-transporter-permease	gnl|CDD|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	5.7208e-15
NZ_CP016793.1|WP_065918123.1|6293397_6293814_+|acyl-CoA-thioesterase	gnl|CDD|238329	cd00586, 4HBT, 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).	3.55701e-15
NZ_CP016793.1|WP_065918125.1|6294629_6295481_+|SRPBCC-domain-containing-protein	gnl|CDD|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	1.22129e-20
NZ_CP016793.1|WP_065918141.1|6307646_6308069_-|hypothetical-protein	gnl|CDD|366388	pfam00960, Neocarzinostat, Neocarzinostatin family.	1.01984e-08
NZ_CP016793.1|WP_065918131.1|6298801_6299068_+|hypothetical-protein	gnl|CDD|380315	cd02138, TdsD-like, nitroreductase similar to Burkholderia pseudomallei TdsD. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.	5.63937e-09
NZ_CP016793.1|WP_065918136.1|6303155_6303545_-|VOC-family-protein	gnl|CDD|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	1.31236e-28
NZ_CP016793.1|WP_065918139.1|6305504_6306698_+|AarF/ABC1/UbiB-kinase-family-protein	gnl|CDD|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	7.17401e-71
NZ_CP016793.1|WP_065918134.1|6301109_6301541_-|ester-cyclase	gnl|CDD|377824	pfam07366, SnoaL, SnoaL-like polyketide cyclase. This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalyzing intramolecular aldol condensation.	4.58298e-27

Protein sequences

>NZ_CP016793.1|WP_065918131.1|6298801_6299068_+|hypothetical-protein
MGGLTARARVEGLHVRQYGGFDRAAVRTALAVPDTHTLVTVVGLRWARPGRAHPPARMSLSDIVFSGRWGIPADLATGKRRLSAESRY
>NZ_CP016793.1|WP_065918130.1|6298538_6298814_+|nitroreductase-family-protein
MAGPGIPPEACTRLFEAARSAESAWNRQPWRFVLGRQADPTYETLLGALADDNRVKAATAVALVLATVRTTDEAGERMRGTEYELGLAWAA
>NZ_CP016793.1|WP_154697599.1|6298299_6298539_+|hypothetical-protein
MRAAMNTRRVIQACTAVVLVPLAEQVLRAGQVHLVRIPEEHANGLLAIAFPQLLEVDWTHHCLALVVLAGLLVTHGPAR
>NZ_CP016793.1|WP_083268262.1|6297385_6298303_+|hypothetical-protein
MQPTFLPDPVVRHRGRLVAWSALAGFLLTVIWSAPFVDRVIGDNVANAMLGHDAKATPLDGVLAGIAFAFVTGLAGSFTACNIAVFGVVTPLVDQGRAKPRWRDSMRALGWICAGAVGVSALYGAVVAIVGTSMPQFATTASVAGVLSPRQVQSMVVFGLIGVAFTYLGLAAVRLVPDPFARIRRRHPAVPLVVMGVLIGALLIGRPFPLFRMMFRHAAESGNVLYGMSAFVLQSLGNLVIAGVVFLVLAHGTGGRVQRWLAAKPGRTERITASAFLVFGVFTLLYWVLRSLGRAGLIWYPAIGW
>NZ_CP016793.1|WP_083268261.1|6296095_6297355_+|AarF/ABC1/UbiB-kinase-family-protein
MFRSVQVVLRAIAVLSICLWHTVLALPSIVRGDVTGRARRLVVALGPAFVKGAQLLSTRRDVLPAGWCEALAELHDRVPPMPVRVARKVLRSAYGGEPPFTVDWDSVRSGSIACVYRAEHDGGAVALKVRRPRVRERIEQDFAVMRAGAAVMQRLPRLRGLPAVAVLRQIGDAVAAQADFGAEAGALAELRESLADVGYLHIPRPLPGLCAEGVLVMEFVDGLTPLDAGDVPAARRSELARRVLHCAYRMLFLDGLVHCDMHPGNLYLGRDGRIVLLDAGFVVRLEPRVRRLFAEFFMHMARGDGPHCAEILRESAEGVADWADVAAFRRGTIALIEQSSGRNARDFSLVRFATRLFDLQRVNGLFAAPEFIFPLLALLVLEGRINALDEELDFQAESIPVLTKAVMSGLLKIGPREQA
>NZ_CP016793.1|WP_065918126.1|6295484_6295991_-|SRPBCC-family-protein
MDVTTLALTVELEVAAPADEVFDAVSDPTRVPAWSPECVHVEWTDGAAAAVPGARFSARNRAGEWEWEVMCEVVEVRKPRTFSWVVLGLHDPSLPSSTWRYELTDRPGGGTLITQTFRHGAGGSHLVTAMRTEPEHADALYEFRRGVLLHNITTTMRATATELGWLRE
>NZ_CP016793.1|WP_065918125.1|6294629_6295481_+|SRPBCC-domain-containing-protein
MADRVSVKAVVFAPTAAVYRAMTTESSLSTWFAEHVDVRLEDGRFEFWGRHTPFGDVPRQTSAAADPGGGLRFDWEIEGMHTVVEMSVRRTATGDTTVSVLHEPVPFWGFDRASMNDFWGVAVGNLANFAEGRTLAPRPDYTAGQQDTATASIVIDADAAEVFSVLVDPAQIDRWLPAESVVEPWEGGRYDFGWDHGPMTVVDIEAPHRLAYTWHNDGWPDTLVSWELTEEEGAGTRVSLRHSGFVDGRPSDGYQLGWQGLLINLQRMLEIGERWQQPRWHHD
>NZ_CP016793.1|WP_065918124.1|6293846_6294590_+|SRPBCC-domain-containing-protein
MARRIVKEIEVEAPLEQVWQSISSGSGFATWYVPHAIEPEPGGMVRTDFGPGGVREGVVLAADPPRRLVYGGFGAPGEPVYCYEFALAAAGGGQTAFRLVQNGFPDSERWDQEYDALDACWDLFLHNLRAYQRHFAGLPATLAMATTRPAGGDGWGRLIAALGVSARCSVGDRVVVDVPGVDLVEGVVDFLHPGRHLGVRTACGLRRFSAEGAQLCGVRVHQYRYGTPPLRPDAAACWQRWLDDRFA
>NZ_CP016793.1|WP_065918123.1|6293397_6293814_+|acyl-CoA-thioesterase
MPEHYVHRHVVTLDETNLVGNVYFAHYLRWQGHCREHFLADHAPGVLRRLTAGELVMVTVSCRMDYFAECFALEEIDVLMSLSDTGGNRVVMDFEFRRGAVVVARGAQTVACMRRTGDGVTPVEVPAELAVALAAYTR
>NZ_CP016793.1|WP_065918122.1|6291539_6293405_+|polyketide-synthase-dehydratase-domain-containing-protein
MAPPGSPRAAPRSRESAQLVVLGRRPAEDPDVAAECRSAPTTSAATSPARCAAVREAARTVRGLLHGAGINHPRRLAEVTEEGLAATVAPKVDGLRELLAAAGAELRLVVGFGSIIGRQGLAGQSEYCVANDWMRVELERWARRNRRCRTHLLEWSAWSGVGMADRMKVTTQLSRLGLALVEPEQGVTAMLDALTDPTAPVTLLVAGRFPATATLRVDPEHHPSPAGLRFAERLPSWVPGVETIAEATLNTGTDPYLSEHRVSGVLVLPAVLGAEAMAQTAALTTGPRGSWTFRGLELHRPVTVGERSDRVIRVAALARRDRRVELTVRQDGDRFGSDHMSATLVPSSPPPARRAAATAPATGPVHHAYGSVLFHSGRFQRVVRYDRLSAFTVTAWVHAREDMWFASYHGSRLLLGDPAAHDATIHALLPCVPHKRALPVGVEELNVWRKPVGMLQVHAVERWHSASEFVFDVDLVQPDGLPVARWTGLRLKAVGDNDLAGPMPFDHFGPWLSRRLVEQGWADRVELWDDLRVAADHPVGLHWTVEDVEPGAAAVKALAVLGESGVVAGRPLAEEDAVRFDEVTGDGLMAATARGARVVVAQRETDRGRVTAALAMGERDA
>NZ_CP016793.1|WP_083268263.1|6299741_6300377_-|PadR-family-transcriptional-regulator
MADCPEVVHRTSGRRRNTVAQEEVPSQDPALPATAYAVLGLLSFGQELTGYDLRKWAMNMRYFYWSPAQSQIYLELRRLLQHDLVEVQVEEQKSRPDKRLYRITEAGLKVFREWLDHAPVGPPLLKHSVALRLFFGHQTDHARLREVLTEYRDWAVEQTTGLTELRTELDQRLPYPALVATWGSAYFAAEITAIDAVLADLDRMDREEEAD
>NZ_CP016793.1|WP_065918134.1|6301109_6301541_-|ester-cyclase
MTNELRNEETLRALYDKFNENDLDAASELLTEDYEGLDVPSGEVVRGRAGWKQRQAANRAPLPDARTTIQSLVVKGDFAVAEVVNEGTHTAPFPLPGGGEHPPTGNRIRGLSCELYEFQDGKIAKGTLYYDFLTVATQLGLKF
>NZ_CP016793.1|WP_065918135.1|6301802_6303038_+|VCBS-repeat-containing-protein
MGAGTRVSRKVAVSLVAVVLVAGCTTRSEQPNSPPGASSETRPTATAPVATVPSAGTPAPVPPPATQASFAAVATFKAGDASADILAADLNGDGALDLATPNYNSNDVAVMLADGGGGYQAPVILTAGRTPNGLAAGDFNSDGHQDLVAANLGSDDVSLLLGDGTGKFGAPTAFPAGDGPARAVARDLNGDGFLDVVTPNLNGDDVTVLLGDGKGGFAAPGHHPAGDGALRLSVVDLDGDRKLDLAVSNYNSGDITVLKGDGGGRFGPPTAYPAGDTSAGAAIADFNDDGFADIVSALYEVDQIAVLFGDGKGGFGGPVVLGSGEHPSDTGVGDFNGDGFADIVAPNFDSDDVSLLHGDGKGGFSAPVSVKVGSGAPAIVVTDFNGDGKADFATADSLADTVSVLLNTTGG
>NZ_CP016793.1|WP_065918136.1|6303155_6303545_-|VOC-family-protein
MSPHRGALAWFEIHVRDVTKAAEFYGTVFGWTFDPLGDADESLDGYLVITLANGEGAGGGLARTATPDEPAGRASSVLYLQVDDIPRTVELALSAGAAVHRPLMDIGGGHGLCAIIRDPDGNHVGLWSS
>NZ_CP016793.1|WP_065918137.1|6303677_6304895_+|cytochrome-P450
MTQLAGQPLPLACFDPSAPEVQRDPYPHYDRLLREDPVHRGVNGIWFVSRYDDVRTVLGEDRLVRQGIRDFWSQLVGPGPLSGILSRTVLFQDEPDHTRLRTLIMPAFAPRALRALEAEIDRLVAELVGQDAGELDVINDVAYPLALGVISTVLGLPAHDRDRLRAWSLRIGPTLDLAAGPAEIADGQAAMAELTGYLTDLVDTRPASGDLLGILCADGDTSREEIIAMVVTLIFAGHETVTNQIGNGVLALAAHPEQLELLRSRPGLVPGAVEEILRYDSSVQSNSRQLADDLELGGKTLRRGELVVALMGAANRDPARYAEPGRFDVTRTGVHPLSFGSGMRHCVGAVLARLELVAAFRALVRLPGWRLPTDPDALQYQRSTMFRGVLSLPLAHEAQTPRRTP
>NZ_CP016793.1|WP_065918138.1|6304891_6305503_+|hypothetical-protein
MTTTTSPDRSDPFVVPNSQHHVGLSIRGQLTVLFSDGETLDCADVKGLSAVRSSQEVTTLPDGRPRIAVTRLMTHFHSNETGLLIQQNPARPNLGILTGLRAGGVEALLPADVVFEQYLVISLRGSLYLNLDPLVMEAKGITTFPPVGTTFLSRTPTTFYDVAELDGGLYATSAGSAKPRLALASTSVCGSHVTHEIDLSSDD
>NZ_CP016793.1|WP_065918139.1|6305504_6306698_+|AarF/ABC1/UbiB-kinase-family-protein
MRAAVALRACEVLAVVTATGVRAVFSRRRTDLLADAVVRLGPAFLKVAQLLSTRVDVVPPKVCRALSHVYDDLPVVPVDQAWRRFPARLRDDLVALTPTAAGSIACVYRGELRDGGLVAIKVRRPGVGRIVSRDLELLRGLARLAESWRLLGGMPVADVAGEIAGAVRQQLDFEAEAVALRDLGANLAAVAGVRVPEVRGEYCGPGVLVMEHVPDLRAGTVAAQAKREATLTALRAVYQMIFLDGLVHCDLHPGNLYPMPDGSAVIVDAGFCRRMSDGGRRAFVEFFYRMTRGDGAACADVVLATATATARSDRAGFRAAMIELVESATRDSVADFDLVPFTVRLFAVQREHGLAADPAFVFPILALVVLEGTLREVCADVDFQAEALPFVLRGMMT
>NZ_CP016793.1|WP_065918140.1|6306744_6307533_-|hypothetical-protein
MVNRFSGGVAAVIAATALVIVPVEAGADDRGGSVVITADQDCYEFAERTRITLDQARKLIPARYTAQESPDARGMVDVFMGDYACKSISLNGKPGRPTMVTMASVNLATRDGKPVPQGTAFPLWWGTDHKELARAVQRLGAPARVIEGKQSVKDIGGGKLHVTNAYWGDKVDHVRTAVVPDLSKAPLHRVITPTGYYQGERGEVQFVYDMKLHVVFGAADLTTVSHPRSDIVTQYGFPQVYQGPTDYLVGTWTLKIELKRRS
>NZ_CP016793.1|WP_065918141.1|6307646_6308069_-|hypothetical-protein
MRSALRVAAPVAAVLLAFAGPPALASAGTISASPTSGLIDGQQITVRGSGFAAGDEVWISQCGTIGGLLRCSGAEGQVVSAVADASGSVSAQLLVRTTFTGYDENGQPAGQIDCAQASGCFVSASVGTGPELNRVAISFR
>NZ_CP016793.1|WP_065918142.1|6308113_6308914_-|ABC-transporter-permease
MSLGAALSDGVALTHRNLIKIKRVPDLLTTSLMGPIMSLLLFAFVFGSAIEVPGLSYREFLIAGIFTQTIAFNVVTTGSGLADDIQRGIMDRLRTLPISSSAVLVGRTTSDLMNNALALLVMSLTGLLIGWRVHTSVLEVIAGFLLLLLFGYAMSWVMAVVGLSVRAPEMVTNASFMVVMPLSFVANTYVSTERMPGVLRVIAEWNPISAVTQAARNLFGNVNPAAPPPGAWPLQNAELASVGWIVVIMLIFVPLAIQRYNKAVSR

Crispr_ID: NZ_CP016793_13

• CRISPR_ID: NZ_CP016793_13
• CRISPR_location: 6862448-6862551
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016793_13

Consensus_repeat	Method
CCGACTGCGCCGGGTGCTGCACTCGGG	CRISPRCasFinder

spacers of NZ_CP016793_13

>13.1|6862475|50|NZ_CP016793|CRISPRCasFinder
TCGGTTGTCGGCTCGGCGGCTGTTGGCCTGAGCGGCGTCCACCGGGCATT

CRISPR arrays and Neighbor proteins around NZ_CP016793_13

CRISPR arrays

The CRISPR arrays of NZ_CP016793_13

>merge|NZ_CP016793|13|6862448-6862551|CRISPRCasFinder
CCGACTGCGCCGGGTGCTGCACTCGGGTCGGTTGTCGGCTCGGCGGCTGTTGGCCTGAGCGGCGTCCACCGGGCATTCCGACTGCGCCGGGTGGTGCACTCGGG

>NZ_CP016793|13|11|6862448-6862551|CRISPRCasFinder
CCGACTGCGCCGGGTGCTGCACTCGGG	TCGGTTGTCGGCTCGGCGGCTGTTGGCCTGAGCGGCGTCCACCGGGCATT
CCGACTGCGCCGGGTGGTGCACTCGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_065918514.1|6860946_6862410_+|phytoene-desaturase	unknown	unknown	gnl|CDD|274273
NZ_CP016793.1|WP_053734851.1|6857455_6857743_-|WhiB-family-transcriptional-regulator	unknown	unknown	gnl|CDD|376791
NZ_CP016793.1|WP_065921536.1|6865468_6866620_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NZ_CP016793.1|WP_154697642.1|6856592_6857459_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133379
NZ_CP016793.1|WP_065918510.1|6855125_6856586_+|cryptochrome/photolyase-family-protein	unknown	unknown	gnl|CDD|225588
NZ_CP016793.1|WP_065918512.1|6858827_6859754_-|phytoene/squalene-synthase-family-protein	unknown	unknown	gnl|CDD|173831
NZ_CP016793.1|WP_065918517.1|6864815_6865472_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP016793.1|WP_065918522.1|6871084_6871786_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065918513.1|6859875_6860943_+|polyprenyl-synthetase-family-protein	unknown	unknown	gnl|CDD|173833
NZ_CP016793.1|WP_170068004.1|6862634_6863855_-|MFS-transporter	unknown	unknown	gnl|CDD|340863
NZ_CP016793.1|WP_065918518.1|6868112_6868532_+|FixH-family-protein	unknown	unknown	gnl|CDD|379037
NZ_CP016793.1|WP_065918511.1|6857836_6858811_-|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl|CDD|334028
NZ_CP016793.1|WP_065918520.1|6869640_6870159_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_154697643.1|6866756_6868094_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065918519.1|6868544_6869648_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065918508.1|6851439_6851757_+|lycopene-cyclase-domain-containing-protein	unknown	unknown	gnl|CDD|274590
NZ_CP016793.1|WP_065918516.1|6864023_6864773_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl|CDD|274422
NZ_CP016793.1|WP_065918521.1|6870225_6871077_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065918509.1|6851743_6852436_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|225136
NZ_CP016793.1|WP_083268308.1|6852432_6853860_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|225885

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065918514.1|6860946_6862410_+|phytoene-desaturase	gnl|CDD|274273	TIGR02734, Phytoene_desaturase_lycopene-forming, phytoene desaturase. Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	3.15245e-175
NZ_CP016793.1|WP_053734851.1|6857455_6857743_-|WhiB-family-transcriptional-regulator	gnl|CDD|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	3.37298e-22
NZ_CP016793.1|WP_065921536.1|6865468_6866620_-|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.37622e-25
NZ_CP016793.1|WP_154697642.1|6856592_6857459_-|MerR-family-transcriptional-regulator	gnl|CDD|133379	cd01104, HTH_MlrA-CarA, Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA. Helix-turn-helix (HTH) transcription regulator MlrA (merR-like regulator A), N-terminal domain. The MlrA protein, also known as YehV, has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella typhimurium. Its close homolog, CarA from Myxococcus xanthus, is involved in activation of the carotenoid biosynthesis genes by light. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules. Many MlrA- and CarA-like proteins in this group appear to lack the long dimerization helix seen in the N-terminal domains of typical MerR-like proteins.	2.7458e-20
NZ_CP016793.1|WP_065918510.1|6855125_6856586_+|cryptochrome/photolyase-family-protein	gnl|CDD|225588	COG3046, COG3046, Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only].	1.61183e-144
NZ_CP016793.1|WP_065918512.1|6858827_6859754_-|phytoene/squalene-synthase-family-protein	gnl|CDD|173831	cd00683, Trans_IPPS_HH, Trans-Isoprenyl Diphosphate Synthases, head-to-head. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze a head-to-head (HH) (1'-1) condensation reaction. This CD includes squalene and phytoene synthases which catalyze the 1'-1 condensation of two 15-carbon (farnesyl) and 20-carbon (geranylgeranyl) isoprenyl diphosphates, respectively. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DXXXD) located on opposite walls. These residues mediate binding of prenyl phosphates. A two-step reaction has been proposed for squalene synthase (farnesyl-diphosphate farnesyltransferase) in which, two molecules of FPP react to form a stable cyclopropylcarbinyl diphosphate intermediate, and then the intermediate undergoes heterolysis, isomerization, and reduction with NADPH to form squalene, a precursor of cholestrol. The carotenoid biosynthesis enzyme, phytoene synthase (CrtB), catalyzes the condensation reaction of two molecules of geranylgeranyl diphosphate to produce phytoene, a precursor of beta-carotene. These enzymes produce the triterpene and tetraterpene precursors for many diverse sterol and carotenoid end products and are widely distributed among eukareya, bacteria, and archaea.	1.07971e-87
NZ_CP016793.1|WP_065918517.1|6864815_6865472_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.82002e-64
NZ_CP016793.1|WP_065918513.1|6859875_6860943_+|polyprenyl-synthetase-family-protein	gnl|CDD|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	5.80369e-69
NZ_CP016793.1|WP_170068004.1|6862634_6863855_-|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.56677e-48
NZ_CP016793.1|WP_065918518.1|6868112_6868532_+|FixH-family-protein	gnl|CDD|379037	pfam13115, YtkA, YtkA-like.	1.43994e-08
NZ_CP016793.1|WP_065918511.1|6857836_6858811_-|Rieske-2Fe-2S-domain-containing-protein	gnl|CDD|334028	pfam00355, Rieske, Rieske [2Fe-2S] domain. The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilizes the protein.	8.08589e-16
NZ_CP016793.1|WP_065918508.1|6851439_6851757_+|lycopene-cyclase-domain-containing-protein	gnl|CDD|274590	TIGR03462, Bifunctional_lycopene_cyclase/phytoene_synthase, lycopene cyclase domain. This domain is often repeated twice within the same polypeptide, as is observed in Archaea, Thermus, Sphingobacteria and Fungi. In the fungal sequences, this tandem domain pair is observed as the N-terminal half of a bifunctional protein, where it has been characterized as a lycopene beta-cyclase and the C-terminal half is a phytoene synthetase. In Myxococcus and Actinobacterial genomes this domain appears as a single polypeptide, tandemly repeated and usually in a genomic context consistent with a role in carotenoid biosynthesis. It is unclear whether any of the sequences in this family truly encode lycopene epsilon cyclases. However a number are annotated as such. The domain is generally hydrophobic with a number of predicted membrane spanning segments and contains a distinctive motif (hPhEEhhhhhh). In certain sequences one of either the proline or glutamates may vary, but always one of the tandem pair appear to match this canonical sequence exactly.	9.64989e-11
NZ_CP016793.1|WP_065918516.1|6864023_6864773_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl|CDD|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	2.76197e-15
NZ_CP016793.1|WP_065918509.1|6851743_6852436_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|225136	COG2226, UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism].	1.68477e-37
NZ_CP016793.1|WP_083268308.1|6852432_6853860_+|FAD-dependent-oxidoreductase	gnl|CDD|225885	COG3349, COG3349, Uncharacterized conserved protein [Function unknown].	1.07742e-26

Protein sequences

>NZ_CP016793.1|WP_065918514.1|6860946_6862410_+|phytoene-desaturase
MVQVVKGSTDRVVVVGAGLSGLSAALHLRGAGHEVTVLERQPHPGGLAGRLDVDGHRIDTGPTVLTMPELLDDAFAAVGQRREDHLELLPLHPAYRATFADGSALDVHTDGERMEQAVRDFAGDREAQGYRDLRAWLTKLYQVERDRFIGASFDSPLDLVGPDLLKLTRLGGFGSLGKAVGKFLHDERLRRVFTFQALYAGVAPKDALAAYGVIAYMDTIAGVYFPRGGMRAVPQALADAAARAGVEFHYGVEVSELERTGHRVAAVRTAEERFPCDAVVLATGPAQSTRLLRGEPKRVVPLRWSPSAVVVHLSARRVVDDLAHHTISFGDRWDDTFDEIIKRGRLMSDPSLLLTTPSLTDPALAPEGRHLQYLLAPCPNLDAAPIRWDETAQRYAEQLIAEMTARKLVEDVEPLAVVTPDDWARDGQAAGTPFSAAHTFAQTGPFRPSNLPFRDGNVVLAGSGTTPGVGIPPVLISGRLAAQRLSG
>NZ_CP016793.1|WP_065918513.1|6859875_6860943_+|polyprenyl-synthetase-family-protein
MSLLTSVDTRLSRVDDFSALFDAALHEFLANRPDVAPELAAELREMVRAGGKRMRPRFAWEGWRAAGGGGDEDVVVRALVALELLQCCALVHDDVMDRSTVRRGRPTVHEVFMMRHRRSRWAGSARQYGDSAAVLVGDLALAWADDALVTAGLSGAALQRAWVPWQAMRVEMMAGQHLDLLGVARREESLEQALRVAALKTAAYTVERPLHLGAALADAGPDVVACLREFGRDVGVAFQLRDDLIGVFGDPAVTGKPVGEDLREGKRTALMALALSRATNGSAAVLRRALAGPVNDALVERVCGLLVEIGAVDAVEEHIDVLVTSGLAALDRTALDPEAKRELVKLAGKATVRKA
>NZ_CP016793.1|WP_065918512.1|6858827_6859754_-|phytoene/squalene-synthase-family-protein
MSADRELDAAGIATPALRDAYRRCRELNAQHGRTYYLATRLLSAEQRPAVHALYGFARWVDDVVDDLHSGLDEKNAVLTAIEARLTAALESGTTDDPVLTALLDTVRRYDIPVQHFHDFMTSMRMDLTVTDYPTFADLKVYVHGSAAVIGLQVLPVLGTSVPREEAEPAAAALGVAFQLTNFIRDVGEDLDRDRVYLPADELEAFGVDRERLLHARKVGRADEKVRAALRDQVQRAKKVYAQAWPGIAMLAPRSRPCVLTAYRLYGRILDLVEDADCDVLSRRVVVSNGRRLAVALPALARAVFARAA
>NZ_CP016793.1|WP_065918511.1|6857836_6858811_-|Rieske-2Fe-2S-domain-containing-protein
MGKSMRDRIPLRIYSSPPWREQRPTWQDAKPALIEAALKRATARPSGNWFVAGASRDVVRGKVCGRTIAGQEIVLWRGPHDVLMAGSGSCPHLGAPLCDGAVAEGKLICRWHGLALDGTRFGAWTPYPAHDDGVLVWVRLDGVGGEDPLPAPVLPDRPPADAIDAVATLIGRCDPEDVVANRLDPWHGAWFHPYSFANLNVLETPTDADDKFLVEVTFRLAGKVGVPVVAAFSCPEPRTVVMHIVEGEGQGSVVETHATPIREGRTAVVEATIAHSDRPGFAYARPAAGALRPVMRWAAARLWRDDLEYAERRYALRRNGRFPD
>NZ_CP016793.1|WP_053734851.1|6857455_6857743_-|WhiB-family-transcriptional-regulator
MPELSRLPRPVAESWDWQLSGLCRGMDSAYFFHTPNERGAARDQREAAAKAICQRCPVMEKCRSHALEVHETFGVWGGLGESELRAILSERARRR
>NZ_CP016793.1|WP_154697642.1|6856592_6857459_-|MerR-family-transcriptional-regulator
MTYAPRAVAAMLGVSPVTLRTWDQRYGLGPSVRTRGGHRRYQDEDVEVLRRMVALTGQGVAPAAAAELAQREPARPHPRGRAQLREDEAESARRGFVTAAKRLDEPLMLDLAGKLLTGHGVVAAWDQVFAPCLVELGHMVAERGRGVEVEHLASSSLLHALRSVPPTGSSGVLAALLSCAPEEQHGLALEALGAALSEEDVRWRNLGARVPARALCDAVLRLRPAVALVWAHRADIAEQVPLAELVAGSGAEIAVAGPGWAGLALPSSVRTPHTLTDAIRLVVSRVRG
>NZ_CP016793.1|WP_065918510.1|6855125_6856586_+|cryptochrome/photolyase-family-protein
MTAQEKTALLLFGDQLGPHFYTGHDEIVLIESATALRRKPYHRQKLHLVLSGMRHLAAEMPDRVTLVRANTYREAIRELNRPLVAYQPGSAAALKMVHDLGVEVRPTPAFALGRDEFTAWAGNRERFRMEDFYHFQRTRFDVLVDGSEPVGGRWNLDTENREPPPRRARLGVPEPWWPDEDDIDAQVRADLDAMDLPAVGRDGPRRFAITRAEALAALEVFLRDRLPHFGPHEDAVLTEDWTMAHSLLSVPLNHGLLHPLEVVYAAEDAHRSGDVPLASAEGFIRQVLGWREYVWQLYWHLGEEYQQRNGFQATEPLPEWWSELRPGGVRAACLRTALQGVRDHGWVHHIQRLMVLGNHALQRGYDPAALNEWFITSFVDGFPWVMPVNVIGMSQHADGGVIATKPYLSGGAYLNRMTDHCGGCWFDPKRRTGERACPFTAGYWAWLDRHEERVRGNRRMVRAVQGLRRLNDLDDVRVQEREREIF
>NZ_CP016793.1|WP_083268308.1|6852432_6853860_+|FAD-dependent-oxidoreductase
MRDRRAVRVPAPAGRAQFTGDAPVVAVVGGGIAGLAASTLLAERGARVVLCERETYLGGRVGGWSTRLADGSEVTMTRGFHAFFRQYYNLRALLKRVDPAGRALTALPDYPLQHASGHRDSFAGLPTAVPWNALAFLRGSPTFQWRDLPDVNARAALSLLDVSVPRVYRELDGIDAATYLDRIRFPKAAHALAFEVFSRSFFAHPSRMSAAELAVMFHIYFLGSSEGLLFDVAADPFPHGLWEPLGRHLASLGVTLCTGVEVRAVGPGEQKRYSVTIGDGAIEADAVVLAADVPGLRAVVEASPALGDAGWRERVGELRTAPRFLVSRYWLDRPVDADRPGFLGTSGHDLLDNISVLDHYEHEARAWAARTGGSVVELHGYALPSDVDEADARRRLWEQLTEVYPETKGAAVVDERHELREDCPLFAAGGHARRPGVRTPDEFLVMAGDLVRIDLPVALMERAATTGFAAANQAL
>NZ_CP016793.1|WP_065918509.1|6851743_6852436_+|class-I-SAM-dependent-methyltransferase
MNKLEVPGKFDWAARGYDLLVGLNPGYHQALRRSAGALRLRPGMRVLDLGCGTGASTAALVTAAPGVEIVAVDASAGMLARAQEKRWPGTVRFVHSRAEDVDEGTFDAVFAAYLVRNLPDPDSTLRHIGKLLKPGGRLVLHEYSVRDSLVSRAVWTALCGVIVPAGWAVTGDRSLYTYLWRSVNDFDGASALRDRLRRNGFTGVRSAPLPGLQLGVVHTFLGHAPEQEQR
>NZ_CP016793.1|WP_065918508.1|6851439_6851757_+|lycopene-cyclase-domain-containing-protein
MGEEYLFAAVTAVVVVVLLELFVLRTGLFTRPAYWVTMAIVLAFQVPVDGWLTKLDAPIVLYADWAVSGVRIPWDIPVEDFLYGFAMVTAVLMMWERGRQAREQA
>NZ_CP016793.1|WP_170068004.1|6862634_6863855_-|MFS-transporter
MKGRVDRDWWLLLVAQAISTTGTQITVVLIPAVAILAFGSGIGPATLLLVAEFLPAAVLGPFAGVLIDRLKPRDVLVAMDLVRTAAPAVVALIIASGVREIWVLYVLAAVLGVAGAVFDTAAEAAIPGLVAPDHLERANATRSSLLNVVRIAGPGLGGLIIAVSAAELALLVTAGTFFASAVVIVGASSATLLSRRSHATERPSVVDQLREGVRYLNGDLVLRRAVLGTATMNLAGSGIGALFFVYAYQQLRLGPDEVGFTMSAFSLGAVLGAAGSAWVTRRLSAALACAVCASVAAGALFLIPAASLGLPFPVLTVYQFVFGAAATAWAVVLLSLRQRRTAPEMLGRVGSLVNAVTVATVPLGAVLGTALAGAVGTTPAMLVLAALAAATPAFYWSPGFRYADSR
>NZ_CP016793.1|WP_065918516.1|6864023_6864773_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MQNPPAFPDLLRLIDERSAVFRSVLATAPDLDARVPSCPEWTLHDLAQHIGEGRRAWAATVAAGPGATGRSPAEGTAPRDRAELDEWLAESTRLLVDALREAGPDRGCWTWWTGSQSPATCGAVARHQLQQMAVHTYDAQLTVGDPQPLPVDVALDGVEEFQLTCVSTTSAWPHEPAVVDYHATEGRSWRLRLSAEGARVVPAEGPADVSATGTASELVLFCYGRHPLDAVEVEGDARIFERLIAWEPA
>NZ_CP016793.1|WP_065918517.1|6864815_6865472_-|response-regulator-transcription-factor
MTLSVLLADDHAMLRSGMRAIFETQADLRCVAEVADGRAAVTEVARLRPDVAVLDIRMPKLDGLGATEQILSDPGNRTKVLLLTTYDSDEYVYRALNAGASGFLLKSLPPEELISAVRVAARGDALIDPSVTQRLIARFAVSLAPPPTPPELALLTAREREVLHLVAAAHSNAEIAARLHVGDETVKTHVSRVLAKLGLRDRVHAVAYAHINGLVQRP
>NZ_CP016793.1|WP_065921536.1|6865468_6866620_-|sensor-histidine-kinase
MDSIKLPLKHQSRLVAVVCMAVDAGFVVYDARSAQQMVVVLAMTLAVDAMLAGPARLSGWVALAQAAVPVVILLTMGRGIDHNDAGMLIAAYRAGAWLRGAPAWASLGVLSASLMTIPLMADHSLVIAALVATKAAVLPWLVGRYTTARRAYLAELEKQREVEKLDAQAAVTKAITEERSAIARDLHDVIVHHVSAIGMHAGAARLGLPDSNPKLATSLRSVEAASRAAMVDLRHLLDLLHGARSEGARQPGLDNLDELFDGVRAAGTPARLLVCGQHREIPESLDITVYRIIQEMLTNALRHGDASGVTVTLEYAPAALTITAENTAGSGNGHSGSGRTGSGRRGLVGIRNRAGMFAGTAQSGLEPDGRTWRTAVTFPLEAS
>NZ_CP016793.1|WP_154697643.1|6866756_6868094_+|hypothetical-protein
MKRSGVILLLVLGAVFSVAAPALADGAQLGGDLHVAQSLGDRELTVVIRRAAEVPGPVHVDVVTHAGTPPGELTLTARAAGARTSTTKVVLGATPGFHSGVVHVDRPGPWELAVDEASIPFVVPAIVPSPWENATYGGFIAAGVFLFAALVLAVLGMPGLALVPTGGVVASVAVAVTAALLAPSIPPVPAPGTQLDPTYESVLDPYQRTSIVDFSRPPVNLVPRMDGSDLVLDLTDGSSGRPVDDLLVHDNAFIHLVVVSPAGNLRHLHPVRTGPGEYRARLSGAEQGTHALAAEIARRGGGVQLLRSSIDVTGGAPAPSADGKADVAMDIREAGRPSTITARFGESDLQPWLGMLGHMIVVGPVTDSPVKAPIWAHVHSMIPPVPGMPGQPDESVAAYGPDVPFTYSFPLPGRYLVWIQVERDYSIVTVPKVVDVPAAKGVATK
>NZ_CP016793.1|WP_065918518.1|6868112_6868532_+|FixH-family-protein
MSWPCWRWSSQWSALVVLWPRSVEAQPHLAETDQLRFVLTPASTRSGTNSFDLTVTDRAGGPVQGEVTVEPAMPQMGHAVAPITAAPLRPGHYRVGSVDLFMAGQWEITVSLSTASTSTASLSTVSLSAGRVVIPLLLT
>NZ_CP016793.1|WP_065918519.1|6868544_6869648_+|hypothetical-protein
MAITASAVVAPSARTVPKGVVPASLVVGGTLISLIGLTWDIQWHSDVGPDTFFTLPHLFLYAGSAISGLASLVVVLLTTAATKRGRQVDSIVGGRAVGVFGRTFAAPVGYLISGVGAALFLVYGLWDQWWHSLYGFDAVIASPPHIGLLLSISITMVGAVMVFAVARDHPWGTYGVVSSSAVLLAFSMVTVIGLEALPNGVVNSITVGAAFFSVMILLMAGNALNRRGGALAVAVAVALLQAVFWWFSPWATEVYANATGLPLRDYADGVPALPNLIPMALVLVAVAAELLHKLPAWIPGALGGVIITACAPLQNMLVHGGGRFPALDRYLATIAAGAVFGALAGMAGRRFGLTLRHLAPAKEKSHA
>NZ_CP016793.1|WP_065918520.1|6869640_6870159_+|hypothetical-protein
MRKTLLGFAGAAALLLGLASPALAFEPVNVVHTEKVQAGPYEVTVGFSTWPLKAMQSLDFTFAPEDGITGKQGTLTMLYGNEVMDDDPLARHPRKREVWGLDVQALPEPGTWAMKFDITGPEGAGSGELKNLRVMEQPGPPMGLSWAISTIPLFGLVALIVVAVRRTRENVS
>NZ_CP016793.1|WP_065918521.1|6870225_6871077_-|hypothetical-protein
MIRRLVPLALALWFTLHRRTDPSTPGTGGRPPQRQGSVDAGAGVRSAQERTGEIAERGRSGQAGSNDVTLPSDARPWRQRDIPRILEAEQVRNDIRPGIQRAVDDAAAEFHARPADQRYTGDRAATVDAARDRAEALTEQRQREAAEVAAGRGDPAELERLRAEESNAWRNLNTTRAREAGSEIHAIFARNIEDRHQAILGNHAGDYRLRTEAPYDIDGRAAYPGTRRPDLVLERVTPEGQQQYTAHVYDLKTGQKGIEADWEFRVERYARGLFKPEELRPTP
>NZ_CP016793.1|WP_065918522.1|6871084_6871786_-|hypothetical-protein
MTDQSLIAHEQSTREVWTGAGLADSVEGLVDAIKTEGWVDDALAGATLGVEAAATVMDPFSALLANGLGWAMEYFEPLREMLDELTGKPDLVRAHAATWNKIAVELGQMATALGSHVESDLPDWHGEAADAYRSMMGCNVEALGGLSAISAALAEATEGAGGLVELTREIVRDLIADLVARVVVWAVEAIFAVTIPVVAAQIAAAVVKWAGRILTYTMALVASLTNLKKLLEG

Crispr_ID: NZ_CP016793_14

• CRISPR_ID: NZ_CP016793_14
• CRISPR_location: 7863659-7863733
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP016793_14

Consensus_repeat	Method
AAGTGGCTCAGCCACTAGGCCAC	CRISPRCasFinder

spacers of NZ_CP016793_14

>14.1|7863682|29|NZ_CP016793|CRISPRCasFinder
CTCTTGACAGCCGGTGGACGGAGGGCGGA

CRISPR arrays and Neighbor proteins around NZ_CP016793_14

CRISPR arrays

The CRISPR arrays of NZ_CP016793_14

>merge|NZ_CP016793|14|7863659-7863733|CRISPRCasFinder
AAGTGGCTCAGCCACTAGGCCACCTCTTGACAGCCGGTGGACGGAGGGCGGAAAGTGGCTCAGCCACTTGGCCAC

>NZ_CP016793|14|12|7863659-7863733|CRISPRCasFinder
AAGTGGCTCAGCCACTAGGCCAC	CTCTTGACAGCCGGTGGACGGAGGGCGGA
AAGTGGCTCAGCCACTTGGCCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016793.1|WP_065919231.1|7867821_7868439_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP016793.1|WP_065919224.1|7855398_7856274_-|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl|CDD|223406
NZ_CP016793.1|WP_065919221.1|7852050_7852866_+|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|119339
NZ_CP016793.1|WP_065919222.1|7852924_7853422_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224759
NZ_CP016793.1|WP_065919235.1|7872297_7873446_+|sulfotransferase	unknown	unknown	gnl|CDD|379204
NZ_CP016793.1|WP_071812759.1|7868475_7869405_+|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl|CDD|235375
NZ_CP016793.1|WP_065919230.1|7863772_7865098_+|SLC13-family-permease	unknown	unknown	gnl|CDD|115789
NZ_CP016793.1|WP_154697746.1|7858699_7859779_-|HEAT-repeat-domain-containing-protein	unknown	unknown	unknown
NZ_CP016793.1|WP_065919234.1|7871242_7872301_+|DUF1214-domain-containing-protein	unknown	unknown	gnl|CDD|377698
NZ_CP016793.1|WP_065919233.1|7869404_7871186_+|adenylyl-sulfate-kinase	unknown	unknown	gnl|CDD|180120
NZ_CP016793.1|WP_065919223.1|7854130_7855075_+|NADP-dependent-oxidoreductase	unknown	unknown	gnl|CDD|176191
NZ_CP016793.1|WP_065919237.1|7874221_7874689_+|SRPBCC-domain-containing-protein	unknown	unknown	gnl|CDD|176864
NZ_CP016793.1|WP_083268956.1|7873445_7874225_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|181159
NZ_CP016793.1|WP_065921679.1|7865091_7866510_+|acyl-CoA-synthetase	unknown	unknown	gnl|CDD|236096
NZ_CP016793.1|WP_065919229.1|7862938_7863640_-|FadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225097
NZ_CP016793.1|WP_065921678.1|7853564_7854032_+|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380345
NZ_CP016793.1|WP_065919226.1|7857663_7858632_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP016793.1|WP_065919225.1|7856307_7857618_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|185378
NZ_CP016793.1|WP_071812758.1|7859892_7862925_+|carbohydrate-binding-protein	unknown	unknown	gnl|CDD|376446
NZ_CP016793.1|WP_154698066.1|7875647_7877270_+|allantoin-permease	unknown	unknown	gnl|CDD|224374

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP016793.1|WP_065919231.1|7867821_7868439_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.08687e-13
NZ_CP016793.1|WP_065919224.1|7855398_7856274_-|dihydrodipicolinate-synthase-family-protein	gnl|CDD|223406	COG0329, DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane].	5.21794e-59
NZ_CP016793.1|WP_065919221.1|7852050_7852866_+|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	1.82351e-41
NZ_CP016793.1|WP_065919222.1|7852924_7853422_-|MarR-family-transcriptional-regulator	gnl|CDD|224759	COG1846, MarR, Transcriptional regulators [Transcription].	8.83177e-14
NZ_CP016793.1|WP_065919235.1|7872297_7873446_+|sulfotransferase	gnl|CDD|379204	pfam13469, Sulfotransfer_3, Sulfotransferase family.	7.6896e-33
NZ_CP016793.1|WP_065919233.1|7869404_7871186_+|adenylyl-sulfate-kinase	gnl|CDD|180120	PRK05506, PRK05506, bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional.	0
NZ_CP016793.1|WP_065919230.1|7863772_7865098_+|SLC13-family-permease	gnl|CDD|115789	pfam07158, MatC_N, Dicarboxylate carrier protein MatC N-terminus. This family represents the N-terminal region of the bacterial dicarboxylate carrier protein MatC. The MatC protein is an integral membrane protein that could function as a malonate carrier.	9.94075e-55
NZ_CP016793.1|WP_071812759.1|7868475_7869405_+|sulfate-adenylyltransferase-subunit-CysD	gnl|CDD|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0
NZ_CP016793.1|WP_065919234.1|7871242_7872301_+|DUF1214-domain-containing-protein	gnl|CDD|377698	pfam06742, DUF1214, Protein of unknown function (DUF1214). This family represents the C-terminal region of several hypothetical proteins of unknown function. Family members are mostly bacterial, but a few are also found in eukaryotes and archaea.	0.00795744
NZ_CP016793.1|WP_065919223.1|7854130_7855075_+|NADP-dependent-oxidoreductase	gnl|CDD|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.98385e-110
NZ_CP016793.1|WP_065919237.1|7874221_7874689_+|SRPBCC-domain-containing-protein	gnl|CDD|176864	cd07822, SRPBCC_4, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	2.07939e-22
NZ_CP016793.1|WP_083268956.1|7873445_7874225_+|SDR-family-oxidoreductase	gnl|CDD|181159	PRK07890, PRK07890, short chain dehydrogenase; Provisional.	2.90861e-94
NZ_CP016793.1|WP_065921679.1|7865091_7866510_+|acyl-CoA-synthetase	gnl|CDD|236096	PRK07787, PRK07787, acyl-CoA synthetase; Validated.	0
NZ_CP016793.1|WP_065919229.1|7862938_7863640_-|FadR-family-transcriptional-regulator	gnl|CDD|225097	COG2186, FadR, Transcriptional regulators [Transcription].	2.57778e-50
NZ_CP016793.1|WP_065921678.1|7853564_7854032_+|cupin-domain-containing-protein	gnl|CDD|380345	cd02215, cupin_QDO_N_C, quercetinase, N- and C-terminal cupin domains. This family contains quercetinase (also known as quercetin 2,3-dioxygenase, 2,3QD, QDO and YxaG; EC 1.13.11.24), a mononuclear copper-dependent dioxygenase that catalyzes the cleavage of the flavonol quercetin (5,7,3',4'-tetrahydroxyflavonol) heterocyclic ring to produce 2-protocatechuoyl-phloroglucinol carboxylic acid and carbon monoxide. Bacillus subtilis quercetin 2,3-dioxygenase (QDO) is a homodimer that shows oxygenase activity with several divalent metals such as Mn2+, Co2+, Fe2+, and Cu2+, although the preferred one appears to be Mn2+. The dioxygen binds to the metal ion of the Cu-QDO-quercetin complex, yielding a Cu2+-superoxo quercetin radical intermediate, which then forms a Cu2+-alkylperoxo complex which then evolves into endoperoxide intermediate that decomposes to the product. Quercetinase is a bicupin with two tandem cupin beta-barrel domains, both of which are included in this alignment model. The pirins, which also belong to the cupin domain family, have been shown to catalyze a reaction involving quercetin and may have a function similar to that of quercetinase.	2.439e-28
NZ_CP016793.1|WP_065919226.1|7857663_7858632_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.79019e-29
NZ_CP016793.1|WP_065919225.1|7856307_7857618_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|185378	PRK15481, PRK15481, transcriptional regulatory protein PtsJ; Provisional.	9.33771e-162
NZ_CP016793.1|WP_071812758.1|7859892_7862925_+|carbohydrate-binding-protein	gnl|CDD|376446	pfam01055, Glyco_hydro_31, Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.	3.8962e-96
NZ_CP016793.1|WP_154698066.1|7875647_7877270_+|allantoin-permease	gnl|CDD|224374	COG1457, CodB, Purine-cytosine permease and related proteins [Nucleotide transport and metabolism].	5.34947e-17

Protein sequences

>NZ_CP016793.1|WP_065919229.1|7862938_7863640_-|FadR-family-transcriptional-regulator
MSEALRPMVKSRLYEQVLERLRAYVAEAGLKAGDKLPAERDLAASLGVSRASVKQAIVVLEVQGLVEARHGGGTYLVRDTLDVEPVEQLVERRKRLPDVLEAREAMETKLAELAAERRTEAELEAIRAALDFMRDEIAAGGFGVEGDRRFHAAVTAAAHSSLLADFMKTIATQITESRTESLRQPGRPSRSLAQHTAIYEAIAAGEPKKAATAMRRHVQTVAKVRLLDWVPED
>NZ_CP016793.1|WP_071812758.1|7859892_7862925_+|carbohydrate-binding-protein
MRKRATVIPLLALLGLVMPAPAIAQPTDTVVSGQARFQILSPTLVRTEYAGDRRFEDAATYNVVNRSFPRTAYRSRTENGWLVITTSALTLRYRVDSGPFRADNLELKTADGTTASPWRRVVCATGQVCDVEDQQREGMLIAADHPGHTGYGFAAGFQYLNNGVTATVRATAAGRHRIAVRYANGQGGDGKHESRTLSLSVDGKAAQQVTLPATADWRDWRVVETEVDLTAGEHRVALTRGAANTGNVNVDSLALLTPGQAFPAERAIDDCRFGTTCEAENGTTNADIADEHAGFAGNGFVAELVGGTRIGQRVSGVPAAGTYAVQLRYANGQGGDGKHEPRTVFLNGQAVTLPVTANWATWGTVTAQVPLPAGTSDLSLTCPATGCHVNVDTIGVASTTQHLQLGGYRRSLDGYTGNDGPPRLYAGLLHRDGWYLLDDTTSALLNKTTRPDRGAQAYQDGYVFGYGQDYKTALGDLARLTGGSKLLPSWAYGVWYSEYIDRTAADFRDRILPAFREHGVPLDVLVIDTDFKAHNAWNGWRVDPAKFPADFQDWVHGQGLHSTLNIHPSIQADDPDFALAQATAKGKLTKSGSRNGVDSYVFDWGDPDQLRAYLDLHRPMQTDFWWLDWCCDGSGSSQRGVTPDTLINEEYAKLSTLDRGFAFSRGYGSLQAGGYSGAGPLPTGPWAEKRHTLHFTGDTSSTWGAMKGTIGLTSAEGVATGMSNISHDIGGHNDTTGLRGSETYLDNGQVRYTTKLPDDLYARWVQLGAFQPITRLHSNHGDRLPWQYGPAAQASATKFLNLRERLVPYLYTLAEQASQTGVPMVRPAYLEYPNAPEAYSTVDTQFLLGPDVLVAPITTPGEVGETRVWFPPGQWTDYFTGRVYQGNSWTTVSAGWDTMPVFLRSGGLVVERTENVANDAQSKAGSLTVHVTEGAKGEFTLFEDDDRKLSARTRITQENGKVTVHPARGWFPGKVAKRDWTVVVHKADGTTKTVQAMAKSAHQRVVIDIR
>NZ_CP016793.1|WP_154697746.1|7858699_7859779_-|HEAT-repeat-domain-containing-protein
MRTPEVILRDTGWDDLEHAYGPASDAPAQLSALLSEDEEACGDALGFLDAAMLHQGSVYSATLPAAEFVAAVLDDRRVGVPCESALPWDGGERPLRAALLEWLGSFAESLTWDDEDDEEDEDDDPWVAGRALLPGLFDRVAPFLDDTGPAVRQAATGAVAHLLQADELAGRRADVADRLLRAAKDASPVERAGIALSLGGWGIPALLTDEHPGVRACAAVTTAYDDDPAALTEVRLALRDPAAADDLLGEQPPQLEGKLRFQLIKALLRRTTEFDEIVDEAVAVARMTNEYTVDADWGPLLHRAFRGGPADRLSESQRRFLTAVVDNDRCWGSIANRMLWLRRAGLPADRDGLRALLQA
>NZ_CP016793.1|WP_065919226.1|7857663_7858632_-|alpha/beta-hydrolase
MIRALALVLVLVTACATPPAEVPEHAAATQHDPAFARTFRHEFADVDGVRMHYVAGGKGTPVVLLHGWPQTWYGWWQIMPALAEHHTVYAVDLPGLGDSTGAPTGYDKATLARYVHSLMVKLGVRDAGVVGHDLGAAVAFQYAAQFPDDTARLGYLDLPLPGPAVDAAGYRSLSWHIAFHMQPRVPETVVGNDVRDYLALFYPQVSFGGSAFGGTADRSPFSDAEIDEYARTYRRPAVLSGGFDLYRTIDRDVRDTTAAAPVTTPALVLAAQGQIDPIRTIAATRMTNIVRAVDVPRAGHWLVEENPEFVTAELLRFLGNGS
>NZ_CP016793.1|WP_065919225.1|7856307_7857618_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MPISGATAAEIAGSVRDQVASGELAPRTVLPPVRALAAELGVNRNTVALAYRRLVEAGVAETRGRGGTVVAAVPSSPRGCRCGGASVDLASGNPDPALLPDLLAATHAGRYRPPLYGAPAVDEALAGWASADFAEDVDQPFRTLVTHGAVDATERLLNAHLTRGDAVAVEEPCFLASIGTLRLNGYQPAPVPVDTAGMRPDALRAALEGGARAVVCTPRAHNPTGASLTAERAADLRAVLAEHPGVLVVEDDHFSAVSARPYHRITPATTARWALVRSLSKFLGPDLRLALVATDEESATRLETRLSTGTTWVSHLLQHTARTLLLDPAVHELHERAREAYAQRSGLLIDRLRANGFEVLDRPDGLNVWVELDVDSRAVVQGLADRGWAVRPGHLFVRDPSAAGEAIRVTSSTITARQAEAFAAELAAVVAGLRTS
>NZ_CP016793.1|WP_065919224.1|7855398_7856274_-|dihydrodipicolinate-synthase-family-protein
MFHGLSAFPLTPTGEDGIDSNSYARLVARVAAAGVDSIGALGSTGGYAYLTREERAHAVKIAVEAAGGTPVMAGIGALRTSHVLALAEDAQNAGVSAVLLAPMTYQPLTDDEVFGLFADVTRELSVPLCVYDNPGTTHVRFSDELHGRIAQLPNVGSIKVPGVPGPAQARIDALRALVPGTVTIGVSGDWTAAGGLTAGADVWYSVLGGTFPSTALAITRAAQAGTAAGLSEELEPLWTLFRRHGSLRVMSAAASHLGLTGEPNLPRPLRGLDEAARREVVDVLTALGLTS
>NZ_CP016793.1|WP_065919223.1|7854130_7855075_+|NADP-dependent-oxidoreductase
MKAVRFHEFGGPEVLRYEDVPQPVPATGEVLVKVAATTFNPVEGNIRKGVMQGPIPVELPHTPGLDVAGTVEVLGEGVEGFAVGDEVVGFLPMTKPGAAAEYVIAPAAALTPAPKGVPLADAAALPVVGLTAYQALFDHGQLKAGQRVLVNGAGGPVGGYAVQLAKGAGAHVIATASPASAEAVRTAGADEVVDHTTTSVLSAVTEQVDVVLNLAPVDLAVLAELVTLVRSGGVVVNTTIWMPAPTDEDRDVRGVNLYVRSDAEQLAKLVALVDSGDLRVDVAQRVPLTDLPEVHVQAAAGAVRGKVVFLVPGA
>NZ_CP016793.1|WP_065921678.1|7853564_7854032_+|cupin-domain-containing-protein
MSIPHLAQREDQQQLEWIGGSVFSVLLDSETTGGQLTVGRFDAELGEAPPWHMHNNEDEVFLLLSGTALVWVGEEEHELREGGIVFLPRRIPHSYRITSEKADLLLISTPGGLEKMFRHAGRDLREPRPEGFGIPQSLLAEAAELSGNVVLGPPR
>NZ_CP016793.1|WP_065919222.1|7852924_7853422_-|MarR-family-transcriptional-regulator
MPDSPPSLDPVQLGAYFALVEVTSLLRHAVEQQLKEAGDLSYVQFQLLARLGDSPTGSHRMTDLADGVVYSRSGLTYQVGLLEKAGLVERAPSADDERSVTVTITDAGRTLLAAVLPGHVEVVSGLLFEPLSRDDVHRLADLLAPVRDHMRAAPPRSAAPRRRKA
>NZ_CP016793.1|WP_065919221.1|7852050_7852866_+|enoyl-CoA-hydratase/isomerase-family-protein
MTFSTLRTATQDGVLTVVLDNPPVNALSATMMRELRDLLSRLDASVKVVVFESANPEFFIAHVDMHILDQQDLLEELAASTPPGLNIFQHTGELLRHLPQISIVKLAGKARGGGAELVAAADLAFAAEETAGLGQVEALMGITPGGGATQYLLDRVGRNRALELVLAGELVDARTAAAYGWINRALPAASLDAHVAQVARTIASLADGVVAAAKRALPPADLAAGLAVEDDAWASLVTRPAARRLMSEALRAGAQTVDGERDLEGLMRRIA
>NZ_CP016793.1|WP_065919230.1|7863772_7865098_+|SLC13-family-permease
MSAELISILVLVVVFVIATTRSINMGALAFAAAFGVGTLVADMKADDIFKGFPGSLFVVLVGVTFLFAIARANGTTDWLVHMAIRLVGGRIALMPWVMFAITGVLTAIGAVSPAAVAIIAPIAMGFAAKYKISPLLMGVMVVHGAQAGGFSPISIYGTIVNGIVAKEGLPGNEVVLFLASLVVNLLIAAVVFVVCGGLKLARQPVEAPALVRTGADDGGSGGANGGSGGASGDDAVATEERVRLTAPRIATLVGLVALVVGALGFDLDVGLAAITVAVLLSVVWPEQSKLAINQITWPTVLLICGILTYVAVLQSMGTIKWAGDSVAGVGAPLIAALLICYIGAIVSAFASSVGIMGALIPLAVPFLLQGEVSAVGLIAALAVSATVVDVSPFSTNGALVLAGAQDVDRDRFFKQLMVYGGIMVAAAPPLVWLALVVPGIW
>NZ_CP016793.1|WP_065921679.1|7865091_7866510_+|acyl-CoA-synthetase
MVSALLSSSSNRVALRFGDQTLTHAELTSCAGALARRLAGLPRVAVWATPTIETCVAVVASLLAGVPAVPLNPKVGERELAHIVSDSAPAAVLVAPGAELPSGLQSVPRLDVTLGGASAETFAEPGDEAPALIVYTSGTTGSPKGVVLPRRALTSTLDAVADAWDWTADDVLVHALPLFHVHGLILGVLGPLRRGGTLVHLGKFSTAGLTEALAGDATMMFGVPTMYHRIAEEVGSNPALAEALRGARVLVSGSAALPVRDHERIAAATGQRVVERYGMTETLMNTSVRADGDRKPGAVGVPLRGVEVRLVDDSGAVLDETGAVGEIQVRGPNLFTEYLNRPDATAEAFADGWFRTGDVGTRDPDGHYRIVGRKATDIIKSGGYKIGAGEIENALLEHPAVKEVAVTGEPDDDLGERIVAWVVPSGPAPSERELADHVARLLTPHKRPRRVRFVESLPRNDMGKVMKRALGT
>NZ_CP016793.1|WP_065919231.1|7867821_7868439_-|TetR/AcrR-family-transcriptional-regulator
MSTEQTTAWGDAEGRRRDILASAELILEEQGYAGLTMRAIAVGAGVSSGTVYQYFSGKEDVFAALMERRLDALRSTLAAVDRGLGIAGVLREVEPQVTELWRRFGRSAAQWEAKVLSGGPRGKEVTGSAQVYRKTIKALAQTLAETAQACGQELLDDPALPHWVWDSLIGLADDLLLQGARTSRVKPAQLIEFATGAIERGIVRP
>NZ_CP016793.1|WP_071812759.1|7868475_7869405_+|sulfate-adenylyltransferase-subunit-CysD
MNVVRFGCYGRCVNHLDRLEADSVDIFREAVAESERPVLLYSIGKDSSVLLHLARKAFYPSMPPFPLLHVDTTWKFREMITFRDRTARELRLELIVHRNPECVAANINPFDHGSARHTDLWKTQGLRQALDEHRFDVAFGGARRDEEASRAKERVFSFRTAQHRWDPKNQRPELWRLYNTRTAPGESIRVFPLSNWTELDVWRYVEREQIPVVPLYFAAKRPVVDRDGALIVVDDDRMPLHPGETPREELVRFRTLGCYPLTGAVRSEARTVAEIVEEMRTATTSERQGRVIDHDRSGSMERKKQEGYF
>NZ_CP016793.1|WP_065919233.1|7869404_7871186_+|adenylyl-sulfate-kinase
MELLRFITCGSVDDGKSTLIGRLLYESKLLHSDHLAALEADSRRVGTRGGELDFALLVDGLVAEREQGITIDVAYRFFATEARRFIVADTPGHEQYTRNMVTGASTAQAAVILLDARKGVLEQTRRHARIVSLLGIRHVALAVNKLDLAGYSPTLFHAVSTEFRTFAQELDFASITCVPMSATDGVNVVGRSELTPWYDGRTLLQWLESVEVEEAADGPSRFLVQWANRPDADFRGFSGRVLQGTLRAGDRVRVLPGEQASAVDRIVTMDGDLTEAPTGSSVTVVLAGDVDASRGDVLAAADDPPGTAAAFRAKLVWLNEAELLPGRQYLAKIGARTLGCTTTQALKLNEIGTADVHFDAPVPFESYRTNRDLGSFVVLDRLTNATVGAGMIECALQATNVRWQTLTVDKQARIKRNGHRPCVVWLTGLSGAGKSTIADLVERALHAEGRHTFLLDGDNVRHGLSSDLGFTDADRVENIRRIAEVAALMVDAGLIVLVSFISPFRAERTLARELVGKNEFCEVFVDTPLEVAEQRDPKGLYRKARRGELADFTGIDSPYETPEHPEVHVDTTALTPEAAAAEVLAGLRALGVC
>NZ_CP016793.1|WP_065919234.1|7871242_7872301_+|DUF1214-domain-containing-protein
MPDQAWSRFCQALEQAGQVVLSDQAPDTPLDRAEGYRYLARLTREMLYSCLDNADPDFPRFHELDLVKIGADNPDNVYLSATIRGDRTYRITGTRGSIAYFSIGSKANRYAKDGTMASTGELSDADLVVAPDGTVEIIASQRRQGTNWLPLAPDSTGLVVRQTYLDRTTEVAGQWHVEQVGGPAQPAQLTPEFLAKALQRAALAVHGTAATFAHWTRTFMTRPNELPDFGQEMFQRAGGDPEIFYLHGYWTLRPGEAWVVETDVPDCPYWNFQLDNWWMESLDHRRKITVNKHTAVLGPDGRLTIVVAERDPGVGNWIDTCGHSSGTALLRWLGAAEHPIPKCRVVALEELR
>NZ_CP016793.1|WP_065919235.1|7872297_7873446_+|sulfotransferase
MTVTTALNVDELLTGAATKTGLTDFGDDWFREPLDVLVTSLNTEASLSPTGFQLTRHRLTALLADRLRLRALQREHPEVLDVEVRVAAEICGLPRTGSTLLHRLLAASPQLTSTLSWEVAYPVPFPGEGPDAAERKRRAQERMRVFAQLSPDFGDLHTVVWDGPEEDVLLLDRTFVSMSYDSFYRVPSYGDWLRTADQTPAYRELREWLQVLQWQQEGRTQPWVLKSPHHLTAVDTVLDAFPGCKIVMTHRSPVRAVPSYASMVRTMSSQYSEDVDPLWIGPYWSRRFATTLQVFADARQARPDRFVDVRFADTVAKPLVVAHDVLGELGLPPSRADDQAFAAYLRQNRAERHGSHSYSPADFGLAEDRLKRDFAFYTEVYL
>NZ_CP016793.1|WP_083268956.1|7873445_7874225_+|SDR-family-oxidoreductase
MLQDEVVVITGVGPGLGSKLALRAAAEGAKVVMAARSTDVMDQVTKDVTAAGGEAVGVSCDVRKPDQVAHLVDTAVDRFGTITGLVNSAFGHPGFFDLLDTPEKAIRRSMDIILHGALNVTRAVVPHMKAAGRGSIVNIGTMTTRKPMRGEAGYAVAKAAMATATQFLALELGEHGIRANQAVLGWLDGPGVRFYLKLTAESRGVTEQDVYDEIAARNPLGRIPADEACAGAVLFLLSRLASEVTGATLDVNGGEYMPA
>NZ_CP016793.1|WP_065919237.1|7874221_7874689_+|SRPBCC-domain-containing-protein
MTSFPRTHFIESVVVEIEAPASFVWQVLVDYAGYPQWNPYTLAVATSLEVDSPIDLTLPRPDGSPGTFVSREFVRSVVPSRLLRYDTGDTFPGLLGVRDQWITALGPDRCSYYTCETFNGKYADAVVAAQGAYVKQGFDSVAHALRDRVAALVKH
>NZ_CP016793.1|WP_154698066.1|7875647_7877270_+|allantoin-permease
MVERSQTSGTTKETLEDYTLRFAPRTYRRWTPAVVGASALGGIAYMADFSIGAGIGLAHGTGNALLAIGFAALVIFVTGFPLAYYAARYNIDLDLITRGSGFGYYGSVLTSVIFASFTFIFFALEGSIMAQGLRYALGMPLWLGYLLSTLVIIPLVIYGMKVLAKLQSWTNPLWLLLMVAPLLFLVVTQPESVQRFLAHDGGGNGVNTAAVMLGAGVCLSLMGQIGEQIDYLRFMPPRTAANRRAWWTSVVLAGPGWVVFGALKQAIGVFMAVYVLDAVGAVAAIEPIEQFTGVFKQFMPGWLVVPLALVLVVLSQVKINVTNAYSGSLAWTNSFTRVTKRYPGRLVFVCVNLAIALVLMEADMFSFLNKILSFYSNCAMAWVVTVATDIAINKYVLKLSPKQPEFRRGMLFAVNPVGVVSFLASSGLSIGVYFGLFGPAVQPYSPLVAVGIPIVVTPLMAVLTRGRFYLRRTDDGIAEPVLDEDGNPSRTTYECVVCREPYERPDMTASALGGEICSLCLSTDRSGAHVLPATPAITNV

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NC_023286	Streptomyces sp. F12 plasmid pFRL6, complete sequence	162661-162684	2	0.917
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NC_023283	Streptomyces sp. FR1 plasmid pFRL3, complete sequence	229844-229867	2	0.917
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	MF189171	Arthrobacter phage Correa, complete genome	20239-20262	2	0.917
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	MK919473	Arthrobacter phage Xenomorph, complete genome	20742-20765	2	0.917
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	MF324906	Arthrobacter phage Cheesy, complete genome	20724-20747	2	0.917
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	MF189175	Arthrobacter phage Tribby, complete genome	20724-20747	2	0.917
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NC_023284	Streptomyces sp. F2 plasmid pFRL4, complete sequence	325619-325642	2	0.917
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	KX557278	Gordonia phage Ghobes, complete genome	6063-6086	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NZ_CP032685	Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence	1241275-1241298	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NZ_CP032690	Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence	1242274-1242297	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NZ_CP033246	Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence	795703-795726	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NZ_CP033248	Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence	795719-795742	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NC_011775	Bacillus cereus G9842 plasmid pG9842_209, complete sequence	162528-162551	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NZ_AP019717	Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence	211420-211443	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	1047068-1047091	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	CP013001	Bacillus thuringiensis strain XL6 plasmid, complete sequence	160393-160416	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NZ_CP039703	Clostridium butyricum strain 29-1 plasmid p-butyl_plas_29-1, complete sequence	467320-467343	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NZ_CP039340	Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence	1153985-1154008	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	MN693755	Marine virus AFVG_250M121, complete genome	51785-51808	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	MG925353	Mycobacterium phage Nozo, complete genome	8547-8570	3	0.875
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NC_013855	Azospirillum sp. B510 plasmid pAB510a, complete sequence	810520-810543	4	0.833
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NZ_CP040452	Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence	1528027-1528050	4	0.833
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	1414915-1414938	4	0.833
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	200470-200493	4	0.833
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NZ_CP032703	Pantoea dispersa strain DSM 32899 plasmid unnamed1, complete sequence	240136-240159	4	0.833
NZ_CP016793_1	1.2|214005|24|NZ_CP016793|CRISPRCasFinder	214005-214028	24	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	1049436-1049459	4	0.833
NZ_CP016793_10	10.1|5214057|29|NZ_CP016793|CRISPRCasFinder	5214057-5214085	29	NZ_CP015369	Methylobacterium phyllosphaerae strain CBMB27 plasmid CBMB27-p2, complete sequence	43855-43883	5	0.828
NZ_CP016793_10	10.1|5214057|29|NZ_CP016793|CRISPRCasFinder	5214057-5214085	29	NC_010510	Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence	391580-391608	5	0.828
NZ_CP016793_10	10.1|5214057|29|NZ_CP016793|CRISPRCasFinder	5214057-5214085	29	NC_023285	Streptomyces sp. F8 plasmid pFRL5, complete sequence	335477-335505	5	0.828
NZ_CP016793_4	4.2|1606927|32|NZ_CP016793|CRISPRCasFinder	1606927-1606958	32	NC_048860	Microbacterium phage Arete, complete genome	2382-2413	6	0.812
NZ_CP016793_4	4.2|1606927|32|NZ_CP016793|CRISPRCasFinder	1606927-1606958	32	NZ_CP015204	Rhodococcus sp. 008 plasmid pR8C1, complete sequence	90877-90908	7	0.781
NZ_CP016793_6	6.1|2013307|33|NZ_CP016793|CRISPRCasFinder	2013307-2013339	33	NZ_CP011808	Pandoraea faecigallinarum strain DSM 23572 plasmid pPF72-1, complete sequence	306078-306110	7	0.788
NZ_CP016793_6	6.1|2013307|33|NZ_CP016793|CRISPRCasFinder	2013307-2013339	33	NZ_CP054615	Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence	259435-259467	7	0.788
NZ_CP016793_4	4.2|1606927|32|NZ_CP016793|CRISPRCasFinder	1606927-1606958	32	NZ_CP024309	Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3b, complete sequence	245033-245064	8	0.75
NZ_CP016793_4	4.2|1606927|32|NZ_CP016793|CRISPRCasFinder	1606927-1606958	32	NC_014120	Paraburkholderia sp. CCGE1002 plasmid pBC201, complete sequence	258722-258753	8	0.75
NZ_CP016793_10	10.1|5214057|29|NZ_CP016793|CRISPRCasFinder	5214057-5214085	29	NZ_CP023550	Rhodobacter sp. CZR27 plasmid unnamed2, complete sequence	163185-163213	8	0.724
NZ_CP016793_6	6.1|2013307|33|NZ_CP016793|CRISPRCasFinder	2013307-2013339	33	NZ_CP023072	Sinorhizobium fredii CCBAU 83666 plasmid pSF83666a, complete sequence	681010-681042	9	0.727
NZ_CP016793_6	6.1|2013307|33|NZ_CP016793|CRISPRCasFinder	2013307-2013339	33	NZ_CP023065	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence	677922-677954	9	0.727
NZ_CP016793_6	6.2|2013364|30|NZ_CP016793|CRISPRCasFinder	2013364-2013393	30	NZ_CP022363	Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence	39902-39931	9	0.7
NZ_CP016793_6	6.1|2013307|33|NZ_CP016793|CRISPRCasFinder	2013307-2013339	33	KX752698	Mycobacterium phage Tonenili, complete genome	51385-51417	10	0.697
NZ_CP016793_4	4.1|1606866|33|NZ_CP016793|CRISPRCasFinder	1606866-1606898	33	NZ_CP044066	Cupriavidus pauculus strain FDAARGOS_664 plasmid unnamed1, complete sequence	235093-235125	11	0.667

1. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NC_023286 (Streptomyces sp. F12 plasmid pFRL6, complete sequence) position: , mismatch: 2, identity: 0.917

agttccagcagcagctgcagcagt	CRISPR spacer
agctccagcagcagcggcagcagt	Protospacer
**.************ ********

2. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NC_023283 (Streptomyces sp. FR1 plasmid pFRL3, complete sequence) position: , mismatch: 2, identity: 0.917

agttccagcagcagctgcagcagt	CRISPR spacer
agctccagcagcagcggcagcagt	Protospacer
**.************ ********

3. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to MF189171 (Arthrobacter phage Correa, complete genome) position: , mismatch: 2, identity: 0.917

agttccagcagcagctgcagcagt	CRISPR spacer
agctccagcagcagcggcagcagt	Protospacer
**.************ ********

4. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to MK919473 (Arthrobacter phage Xenomorph, complete genome) position: , mismatch: 2, identity: 0.917

agttccagcagcagctgcagcagt	CRISPR spacer
agctccagcagcagcggcagcagt	Protospacer
**.************ ********

5. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to MF324906 (Arthrobacter phage Cheesy, complete genome) position: , mismatch: 2, identity: 0.917

agttccagcagcagctgcagcagt	CRISPR spacer
agctccagcagcagcggcagcagt	Protospacer
**.************ ********

6. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to MF189175 (Arthrobacter phage Tribby, complete genome) position: , mismatch: 2, identity: 0.917

agttccagcagcagctgcagcagt	CRISPR spacer
agctccagcagcagcggcagcagt	Protospacer
**.************ ********

7. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NC_023284 (Streptomyces sp. F2 plasmid pFRL4, complete sequence) position: , mismatch: 2, identity: 0.917

agttccagcagcagctgcagcagt	CRISPR spacer
agctccagcagcagcggcagcagt	Protospacer
**.************ ********

8. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to KX557278 (Gordonia phage Ghobes, complete genome) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
tcttccagcagcagctgcagcagg	Protospacer
  ********************* 

9. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NZ_CP032685 (Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
agttccagcagcagctgcacgatt	Protospacer
*******************  * *

10. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NZ_CP032690 (Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
agttccagcagcagctgcacgatt	Protospacer
*******************  * *

11. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NZ_CP033246 (Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
agttccatcaggagctgcagcaga	Protospacer
******* *** *********** 

12. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NZ_CP033248 (Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
agttccatcaggagctgcagcaga	Protospacer
******* *** *********** 

13. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NC_011775 (Bacillus cereus G9842 plasmid pG9842_209, complete sequence) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
agttccagtagtagctgcagcaga	Protospacer
********.**.*********** 

14. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NZ_AP019717 (Clostridium butyricum strain NBRC 13949 plasmid pCBU1, complete sequence) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
agttccatcaggagctgcagcaga	Protospacer
******* *** *********** 

15. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
agttccagcagcagcaacagcagc	Protospacer
*************** .******.

16. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to CP013001 (Bacillus thuringiensis strain XL6 plasmid, complete sequence) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
agttccagtagtagctgcagcaga	Protospacer
********.**.*********** 

17. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NZ_CP039703 (Clostridium butyricum strain 29-1 plasmid p-butyl_plas_29-1, complete sequence) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
agttccatcaggagctgcagcaga	Protospacer
******* *** *********** 

18. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NZ_CP039340 (Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
agttccagctgcagctccagcagc	Protospacer
********* ****** ******.

19. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to MN693755 (Marine virus AFVG_250M121, complete genome) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
agttgcagcagcagctgcagaagc	Protospacer
**** *************** **.

20. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to MG925353 (Mycobacterium phage Nozo, complete genome) position: , mismatch: 3, identity: 0.875

agttccagcagcagctgcagcagt	CRISPR spacer
agttcccgcagcagcagcagcagg	Protospacer
****** ******** ******* 

21. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NC_013855 (Azospirillum sp. B510 plasmid pAB510a, complete sequence) position: , mismatch: 4, identity: 0.833

agttccagcagcagctgcagcagt	CRISPR spacer
ctttccagcagcagcggcagcagg	Protospacer
  ************* ******* 

22. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NZ_CP040452 (Halomonas sp. PA16-9 plasmid p_unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

agttccagcagcagctgcagcagt	CRISPR spacer
tgttccagcagcagctggagcacc	Protospacer
 **************** **** .

23. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 4, identity: 0.833

agttccagcagcagctgcagcagt	CRISPR spacer
agttccagcagcacctgcagcgtc	Protospacer
************* *******. .

24. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 4, identity: 0.833

agttccagcagcagctgcagcagt	CRISPR spacer
agttccagcagcacctgcagcgtc	Protospacer
************* *******. .

25. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NZ_CP032703 (Pantoea dispersa strain DSM 32899 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.833

agttccagcagcagctgcagcagt	CRISPR spacer
tcgtccagcagcagccgcagcagt	Protospacer
   ************.********

26. spacer 1.2|214005|24|NZ_CP016793|CRISPRCasFinder matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 4, identity: 0.833

agttccagcagcagctgcagcagt	CRISPR spacer
gtttccagcagcagcggcagcaga	Protospacer
. ************* ******* 

27. spacer 10.1|5214057|29|NZ_CP016793|CRISPRCasFinder matches to NZ_CP015369 (Methylobacterium phyllosphaerae strain CBMB27 plasmid CBMB27-p2, complete sequence) position: , mismatch: 5, identity: 0.828

tgca-ggctggcggtgggcgggtgccgggt	CRISPR spacer
-gcgccgctggcggtgggcgagggccgggt	Protospacer
 **.  **************.* *******

28. spacer 10.1|5214057|29|NZ_CP016793|CRISPRCasFinder matches to NC_010510 (Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence) position: , mismatch: 5, identity: 0.828

tgca-ggctggcggtgggcgggtgccgggt	CRISPR spacer
-gcgccgctggcggtgggcgagggccgggt	Protospacer
 **.  **************.* *******

29. spacer 10.1|5214057|29|NZ_CP016793|CRISPRCasFinder matches to NC_023285 (Streptomyces sp. F8 plasmid pFRL5, complete sequence) position: , mismatch: 5, identity: 0.828

-tgcaggctggcggtgggcgggtgccgggt	CRISPR spacer
ccgca-gccggcggcgggcgggtgccggga	Protospacer
 .*** **.*****.************** 

30. spacer 4.2|1606927|32|NZ_CP016793|CRISPRCasFinder matches to NC_048860 (Microbacterium phage Arete, complete genome) position: , mismatch: 6, identity: 0.812

-cagttcggtcagctcgtgttcgacacgatgaa	CRISPR spacer
gcagaccag-cagttcgtgttcgacacgatcaa	Protospacer
 *** .*.* ***.**************** **

31. spacer 4.2|1606927|32|NZ_CP016793|CRISPRCasFinder matches to NZ_CP015204 (Rhodococcus sp. 008 plasmid pR8C1, complete sequence) position: , mismatch: 7, identity: 0.781

cagttcggtcagctcgtgttcgacacgatgaa	CRISPR spacer
gagttcggtcagctcgtgtgcgagacggtcgg	Protospacer
 ****************** *** ***.* ..

32. spacer 6.1|2013307|33|NZ_CP016793|CRISPRCasFinder matches to NZ_CP011808 (Pandoraea faecigallinarum strain DSM 23572 plasmid pPF72-1, complete sequence) position: , mismatch: 7, identity: 0.788

ctgctgcggcgcggcaggcgtctgaccaggcga	CRISPR spacer
cggctgcggcgcggcaggcgtccgacggcgggc	Protospacer
* ********************.*** . * * 

33. spacer 6.1|2013307|33|NZ_CP016793|CRISPRCasFinder matches to NZ_CP054615 (Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.788

ctgctgcggcgcggcaggcgtctgac-caggcga	CRISPR spacer
ctgccgcggcgcggccggcgtctgctgctgacg-	Protospacer
****.********** ******** . * *.** 

34. spacer 4.2|1606927|32|NZ_CP016793|CRISPRCasFinder matches to NZ_CP024309 (Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3b, complete sequence) position: , mismatch: 8, identity: 0.75

cagttcggtcagctcgtgttcgac--acgatgaa	CRISPR spacer
gagttcggttatctcgtgttcgaccatcagtg--	Protospacer
 ********.* ************   *..**  

35. spacer 4.2|1606927|32|NZ_CP016793|CRISPRCasFinder matches to NC_014120 (Paraburkholderia sp. CCGE1002 plasmid pBC201, complete sequence) position: , mismatch: 8, identity: 0.75

cagttcggtcagctcgtgttcgacacgatgaa	CRISPR spacer
cagttcggtcagctcggcttcgatctggtcga	Protospacer
****************  *****. .*.* .*

36. spacer 10.1|5214057|29|NZ_CP016793|CRISPRCasFinder matches to NZ_CP023550 (Rhodobacter sp. CZR27 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.724

tgcaggctggcggtgggcgggtgccgggt	CRISPR spacer
cccgggctggcggtgggcgggttccacag	Protospacer
. *.****************** **. . 

37. spacer 6.1|2013307|33|NZ_CP016793|CRISPRCasFinder matches to NZ_CP023072 (Sinorhizobium fredii CCBAU 83666 plasmid pSF83666a, complete sequence) position: , mismatch: 9, identity: 0.727

ctgctgcggcgcggcaggcgtctgaccaggcga	CRISPR spacer
gcgatgccgcgcggcgggcgtctgaccattgaa	Protospacer
 .* *** *******.************   .*

38. spacer 6.1|2013307|33|NZ_CP016793|CRISPRCasFinder matches to NZ_CP023065 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631a, complete sequence) position: , mismatch: 9, identity: 0.727

ctgctgcggcgcggcaggcgtctgaccaggcga	CRISPR spacer
gcgatgccgcgcggcgggcgtctgaccattgaa	Protospacer
 .* *** *******.************   .*

39. spacer 6.2|2013364|30|NZ_CP016793|CRISPRCasFinder matches to NZ_CP022363 (Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence) position: , mismatch: 9, identity: 0.7

gtgggaagcctgcggctgccctcctcccgg	CRISPR spacer
acctaccgcctgcggctggcctccttccgg	Protospacer
..  .  *********** ******.****

40. spacer 6.1|2013307|33|NZ_CP016793|CRISPRCasFinder matches to KX752698 (Mycobacterium phage Tonenili, complete genome) position: , mismatch: 10, identity: 0.697

ctgctgcggcgcggcaggcgtctgaccaggcga	CRISPR spacer
ctgctgcggcgcggcaggctgctggttcatcac	Protospacer
*******************  ***... . *. 

41. spacer 4.1|1606866|33|NZ_CP016793|CRISPRCasFinder matches to NZ_CP044066 (Cupriavidus pauculus strain FDAARGOS_664 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.667

cagctccggcacttccttgccgaggtagaaacc	CRISPR spacer
gttctccggctcttccttgccgaagtactgctt	Protospacer
   ******* ************.***  . ..

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	973760 : 991068	21	Streptomyces_phage(92.86%)	capsid,terminase,portal	NA
DBSCAN-SWA_2	5038097 : 5093795	50	Bacillus_phage(25.0%)	protease,plate,transposase,tail	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP016793|973760:991068|DBSCAN-SWA
CTTACGCGACGTCGTCGAGCATCGGCGCCGCGGTGATCTCCAGCCGCTCGGCCGATGCGCTCGGGCTGTACTTGATGTCGACCACGCGGACCGGTCCGTCCCACCCGCGCCGGTGGAACAAGTCGCCAGCCGGGATGATCAGGCGGCCGTCGTCGCCACGGCTGACGTCCGCCGCGGTGGGAGGGACGTCGCCGCGAACCACGAACCGCGGCAGCACCACGGGCAGGCGGGCCGCTTCCTGGTCGCCCTGAGCGTGGGCGCCGAGCACGTCCGGGTCGTCGCCGTCGTAGGAAGTGTCCAGCTCCAGCAGCGGGAAGCCGATGGCGTACTTGCTGCTGTCCTCCGACACGGCGATCGGCGTGCCAAGGTCGACACCTTCACCGACCGCGTACGCGCGGGTGGCCATGCGAGTGCCGTCGGAGTCCCACTCGTAGGAGGTCGCCGATCCGGTGAGCTCCCACACGTGGGAGCTGCCTTGCTGGCCCAGCCACGGTGTGCCTTGCAGCAGCACCCGGTCCGGTGCGGCCGCGCCGGTGGAGCTCGCGGCGACGTCGAACACCATGTCCTGGCCACCGATCACGCCGGTGAGGTTGCGCAACATCTCGCCGGCATTGGACAGCTTGTACGGCGGGTACGTCCGGTCGCGCAGCTGGCCCGATGTGGTGGTGTCCAGGTCGAGGCGGATGCCGATGTCCCCGCCGGTGTGCGACTGCGCCAGGGCGACCAGGTTGCGGGCGATCTGGTTCTGGTCGATGCCGGCATACGACGGCGCCGCGAGCCCGGCGAGGTCGAAGATCCCAGGGGACGCAGGTAGCAGCGGCAGCACCGCGCGGTGGTCGAAGTACGACCACCACTCGCCGGCGCCGATCGTGACGGTCTGGCTGGTCGAGGAGTACTTGCGGGTCCAGATGATCCCGCCCCACATCGGCCGGTCGTCGCGCCAGGCGTAGATGCACCGGCGGGTGGGCATCGTCAGGTCGTACGCGTCGAGGTGTCGCGTCTTCGCGCCGAGCTTCCACGTGGCGTCGAACCGGCCGCTGCCGTTGAGGGGCTTGTTGAAGCTGACCCCGGTGAGGCGGACGTCCTCCAGGATGCGGTTGGTCGCCAGGTCGGCGATCTGGTAGCGGTACACCGGCAGCGCCATAGGACCATCTCCCTTCGGCGGGTGACGTCGCGAGCGCGGTGGTCAGGTGCCGACGAACTTCACGCTCATCGACGAGCGGACGCCGCCACCCGTGAAGGTGTCCAAAGGACCGCCGGAGTCCTGGAAGCCGACCAGCTGGACGTAGTCGCCGGCGGCGAGCTGCACCTGGGTTGTCCGCGCGGGGATGCGCGTAGCCAGGCCGGCACCAGCGCTCGGGAAAGCCAGATCGCTTCCGTCGATCATCGCCCCGTTCTTGTTCCACTGGCTGACGCGGGCGCCGACTCCGGAGGCGGCGAACGCGATGCCACCGTTGAGCTCATACCATCCGGGCACCTGCGCGGTGTACCGCGAGTTGTTCGTCACGTTGTCGTGGCCGGCGAAGTTGTCCCGGTCCTCGACTTGAAAGTTGATCGGCGCACCGACCCCGGTGGTGAGGGTCTGGGTAGCGGTCTGCCGCAACTGTGCCTGGGGCACGCCGCCGCCGATCGGCACCCATGCCGACGTCGCGCCGTCGTACTGCCACAGACAGTCGATGTCGGTGATCATCGTCAGCTGACCCGTGCGCGGGTGGGTGATCGCCGCGTTGCGATCCGCCACGCTCGTGCAGATCGCAACGCCGTGCACGCGCCACGCGCCGCCGTCGTAGATCTCGACCCAGTCCCGGTCAGTGCGGTAGATCGGCATGCCCTCGTAGGGCAGCAGAATCGCGTCCCGCTCGGCCTGAGTGCGGATCGGCAGCAGCCCGCCGGTGGCGACGGTCCACGGCAAGGTGACGTTGGCGATGTCGGCCTGCTCGATATCGGTCGTCCCGGCCGGGACGGTGACCCGCGCGCGGATGATGTAGTCCGTGCTGCCCGACACGGCCGGGTCGACGGGCACCGGCGCCGCGGCCCCGACGACGTGGCGCACCGTGAAGTTGCTGTTGGCGTCGCCGAAGTAGGTGTCGGACTGCTGCCAGACGATCAGGTCGATGCGCGGGTTGGACGGGTCGGCCGGGGTGGACAGGATGTTGATGTCCTTCACCGAGTCCAGGCACACGTTGTAGGTGCCACCGCCACGCACGGACTGCAGCACCGCGCGGAACGGCGCGATGTGCACGAACCCGTTCGGGGTGGGCGTGGTCGCGGTGACCCTGCCCGGCTCGGACGCGGCGGGCACGACGCCGGAGCGGGAGACGATCTGGCCGGCCGGGGTCCAGAACGCGCTCATCGCCAGGCGGGCGTCCTCGACCGTGATCACACCCTCGGTCTCGTCGATGCCGACAGCCCACGAGTAACGCTCTCCCACGGTCGGTCCCTCCTCACAGGTCGGTGTGGTGATACAGGCAGGTCAAGGTGCCGTTGCCGTCGACGGTGTCGAACCGCACGCGCGTCGAGGTGCCGGGCGGCAGGGTGAACCACTCGCGCACCGCGAGCTGGTTGCTGCGCGAGACGGGTGGCGAGGTGTCGGCGTAGAGCACCGACTTGTCCTCTGTGGACAGATCGAGCCGCTCGCCGCTGTTCAGTGCGAAGTCCGGCTCGAACCACAGCCGGGCGCCGGTGTCGGCGTTGGTGATCATCGGGCCGACGCACGGGCCGGTGATGCGCCATACCGGTTGTGCGTGCGCGTGCCCGTCGTTGGCCAGCACGAGCTCGCCGCCCGACGGGGCACCGCCGAACCGCAACGGGAACACCAGCGGGAAGATCAGGCCACCGCCGCCGGACACCGGCGGCGACGCCACCGGCGCCAGCTGCGGCAGCCGCAACATCCGCGGGTTGGTTGCCCGCCACCGCAGGACGATGCGGGTAAACCCGCTGATCCACTCCAGGTGCTGCGGGATGATCCGCCCGACGCAGCGGGCGTTGACCATGGCCTTGATGCCGGCGGTGTGAACGACGAGCGGCTCTTCGTCCGGGTTCTCCGACTGGGTGGTCACGCGCCGTAGCTCGTTGACCGCGTCGGTGAACCCGGACGGTCCGGCGATGTGGCCCTCGAACGTGACCACCTTGCGCGCCAGCAGCAGCTGACCTGGGTGGGCACCATGCTCGTTGTCGAGCTCCACGTCGCCGTCGCGGATGTCGTCGGAGTCGACCCACCCTTCGAGGCCGGTCATCCGGTAGCGGGTGCCGTGGCCCAGAAGCAGCCCCCGCCACTCGACCTGCGTCTGTGTCGGGTCGGTGACGGTGATCAGGTCCCCGGCCGCCATCATCAGCCACCCCCTCGGGAGAACCAGTCAAGGTCTTCCGCCACCTCGTGCGGCGACGCGTCGGCGGGCGGGTGGTAGTTGTCGATGTGCACCAGCGCACGTTCGCGTCGCTGCTCGGCCGCGGGCGCCGCGCCGCTGACTGCCATTGACAGGCCCGGCACTCGCGGTGTCGGGATGCTGACCTCACCGATACCGGCGGTGAATCCCTCCAGATATCGCTCGACCTGTGCCTGCCCGCGGCTGAAACCGTCCACAAGGGACTGCATGATCAGCTCACCGGACGGGGTGAGGATCCGGGCGTCCACGACCGCTGGGCCCTTCCAATCCGGCAGGAGGTTCGTCAGCTCGTTGAGCTTGTCCTTCACCTTCTGGAAACCAGCGGAGATGCCGCGCAGCAGGCCGTCGATCACACTGCGGCCGGCGCCCAGCAACAGCGAGCCCAGGTCGCCGATCGCACCGAGGATGCGGCCCGGCAGGCCGTTGAGCCACGAAACGAGTTCGAGGGCCTTGCCGACCGCGGCGTCGTAGATGCCGCGGAACCAGCCGCCCACCATGCCGGGGAGGCGGCCGAGCCACTGGAAGATGCTGATCGCGGTGTCCACACCGGACTGAAACGCGCTCTTGATTCGGTCCCAGTGGGCGACCACCAGCGCGATGATCGCACCAAGCGGGCCGAGGATGATCGTGATCAACAGCTTCCAATTGCTCTTGACCCAGTTCACCACCCAGTCGACCGCCGAGGAGACGGCGTTCGACACCCATTCCCACGCTGCGGCCGTCGCGGCAGCGATCTCGTCCCAGTAGGCGATGATCAGGGCGACCAGGCCGATCACCGCGGCGATCACCCAGCCGACCGGGCCCATCGCGATCAACCACGCCGCGGCCATGCGCGCGGCGTTGGCCAGCGCCTGGACACCCATCAGCACCCAGCCCGCGACCACGCGCGCGACGTGCGCCGCCATGCTCGCGGCGATGACCGCGCCCTGCGCCACGAACTGTGCGGCCATCACGGCCAGGGAGGCCACCGTGCGGGCGCTGGCCGCGATCCACGCGGCAACCGTGCGGGCGGCCGCCGCGGTGTGCGTGGCGACCCACGACGCCGCCGTGGTGATGCCCGACCACATCGCCTTCGCCATCGCCCACACCGCCGGCACCGCGCGGTAGATCTGCACCAGCGCGGACACGAGCGCGATCACCTTGCCCGCGAGCGGACCGAGCAGGACCGACCACGCCAGGACCGACGCCACGACCGCTTGAGTCTGCGGGTCCATGCTGGACAGCAGGCCCAGCAGAACACCGAGCGGGCCGATCATCAGCGGCAGCACCTCGACGATCGTGTGACCGGCCTGGGTGATCATGTCCCAGACCTGGGCGATGCGTTCCTGACCGGACGCGCTGTTGACCCACGCCGCCATCCGTGCGGTCAGGTTCTGCACGATCGCCAGCAGGCTCGTGCCGCCGGAGTTCGCCGGGCCGAACAGCCCCGACAGCACCGCGCGCACGTTGCCGGCGATCGCGACGAGCTGCCCGATCGTGGTCTGCGCCGCAGCGACCTTCTGGTCCAGCCACGTCGCCCCCTCGGCCGTGCCGAGGAACGCCGCCTTGGCCTGCAGGCCCTTCGCCGCCCACGCCCCGAACGACTCGACCAGCGGCATCCCGGCCTTGGCCATCGCGCCGATCGCCGTGACCGCCGGGCCCACGGCCGGCTTGAACAGACCGATCACCTTCGCGGTGCGGGCCAGCACGTCGGCGACCACGCCGTGCATGAACGGGGTGTTCGAGGCGTTGAGTGCCTCGCGGGCCAGGCCGTTGAGCTGGCCGGCGGTCTCGCCCAGGCCGGCGCGCAGCCCAGGCAGGTGACCCTTCGCCACCGCAGAGACGTCGCCGCCCAGCCGGTCGAAGAAGCGCTGCTGCACCATCTGCTGGACCGGCTTGAACGCCTGCTTGGTGGCGTGCATCTCGCGCACGAACGACCGCGCCGCCGGGGAGAGCTTGCTCAGCGCCTCCTGCGCGGCCGCGGCGTCACCCGAGGCGAGCGCGTCCATCGCCTCGCCGACACCGGCGGTGGCCATCTTGACCGTGGCCATCGCGCCCACCGCGACACCGGCCGCGGCGGGCAGCGCGAACAGCGCCCCGGACAGCGGAGCGACCGCGGCCTTGGCAACGACGGCGCCCTTGGCCAGCAACGCCAGGCTGCCGACCTTGCCCAGCGCCGCGATCGGCGCCTCCATCTTGGACAGCACGGCGTTGGTGCGCTCGACGTCGGCCCGCACGCCGTCGACGTACTTGCGCGCCTTGGCCGCGCCGCTGCGCAGCTTCTTGGGGTCCAGGCCGAGCGAGACCATCAGGGAGGCGAGGGTGGCCACCGCGCACCCCCTCCCGCGTCAGCCGGGTCCGACTAGTCGAACCCGTCTTCGATCGGCCGCTCGATGCCGCCGAGCGCGTTGTTGATCTCGCGAATACGCGCGAACATCTCGGCCGGCGTGAGCGTCGGCCGCTCCCACTGGGGCACAAACTTCTTCAACGCCACGGGCGGCTTCTTGCCACGCTGGGAGTTGACCACCGCACTGGTGACCATCGCCGTCAGGTAGTCGTGGCGGCCGGCACCGAGTGGGCCGGTCATCCGCTCGTAGATCTGCCACTCGACGAGCTCGCTGGAGTCAATCCGCGCGAGAAGCTCCTTGACCGTCATGCCACCGATGTGCCCGGCCAGCCGGAAGTAGAACTGCCGATCCGGCCGGGCCCTCAGTTTCCCTCAAGCTCGTCGGCGTCCTTCTGCGTCAGCCCGGACAGCCGCATCGCCACGGTCATGACCCGGTCCAGCGCCGCCGCGGACTTCTCGCCCAGCGCCCGGACGTCCCGCTCGCTGAACATGCGCCGGCCGTCCTCGTCGACCACGGACGCCATGACCAGGCGGGCACGGAAATTATCGGTGTTGACCTGGTGACGGGCGTTGCCCTTGCCGTTGCGGTTCAACATCGCCGACTCGAACCGGTCGCGGTCGGTGCCGGTCAGCCCGCGCACGCGCACGCGGCCACCCCACTCCGGGACGTCGACGTCCTCGGTGGTGATGTCGACGGCAGACAGGATCTCGTCGCGGGACAACAGGGTGCTCATCAAGGCTCCAATCAGGACGGTGACGGCGACGGCCGCCAGGAACGCGCGGTCAGCGAGCGCGAGGCTCACACGAGCAGGGTGGGCTTGCCGGAGACCTTGAACGTCACCTCGGCCGAGAGCTTGTCGTCGAACGGCGCCTCCGAGGAGAAACCGGTCATCACGGCCTTGATCTGCCAGCCGCCCAGGCCCTCGGGCCACAGGATGCGGTAGGTGCGCGGCTGGCTGTCTTCGTAGTGCTCGTAAAGGGCGTCGTGGTCGCGCGGGTCGTAGTGCAGCTCCAGCGACACCTCGCCGCCGTCCTTGAGTCCACCGATGAACTCACGCCAGCCGTCGGGGCTGTCGTGGGCGGTCACGTCGTGCGTCGCCCGCTCGGTCTCCGGGCCACCGACGTTGGTGCAGTTGGCGATCGGCGTGAAGATCTCGGGCGAGCCGCCGTCGCCGGTCAGGAACTGGGTGCCGAACGCGTCGAGTCCAGCCATCGTTACGGGTCCTCTCGTGTGAGCCACAGCCGGTAGCGCACCGGGATGTGGCGAATCTCAGGGTCGGGATCGCGCAGCGTCTGGTGGAACTCGCGTGCGCACGACACATCGCGGTAGCCGGGCACGAGCAGGGCCTGGCGGTCGAGCAGCCGGTCGACTTGGCCGAGGATCTGCAGGCCCTGCTTGTTGCCGCGGTAGCGGCTGAAGATGTGCAGGGTGGTGGTCACCCGCGATCCGCGCCGCGAATGGTTGTCGTCGGGGACCTCGGTGGTGTCGCCCAGGCGGATGTAGGGGAACGCCGCCGGTTCGGGCACCTGGTCGTAGACACCGCTCACCGCCGCCATCAGCTCGACGTCCGCGGTGAGCAGCGTGTGGATCGCGGTCTGCACCGCGAGCTCCGCGGTCACGAGTCGAGCCGCTTCGCCAGGGCGCCCTTGGCGTAGGGCGTGACGTCGGCGTGCTGCTCGAACGCCGGCACCAGGAAGGGCTGCGCGTACATGCTCTGCGTGCCCTGCTCGACGAACTCGGCGTAGTAGGCGTCTTCCTCCCACACGCCGACGTCGCACTTGAGCCGCTTGCGGTCCGGCCGGGACTCGATCGCCGAGCCGAGGTTGCCGGAGTCGATCGGCACGCGGTTCTGCGCGGTGCCTTTGACGTCCTCGCCCCAGGCCTCGACCGCGTCCCCGCCTGCCTCGATGATCTTCTTCTGCAGCTCGGCGACATCGCGCAGCAATTGCTTGTCTCCCTTGAGGTTGGCGCCCATCGGGTTCACCCCCTTTCGGGTTGCTGCTCCTCGCAGTCCGCGCGCAGGTAGATCGCCTCGGACGGCGCCAGCACGCGCATCACGCGCAGGGTCAAGGCGGCGTCGCGCAGCTCGTCGCCGCGGCGGATCGGCGAGCCGGGCTCGTCGTAGACCTGGTGGGTCAGCTCGCCCTGCTCGGTGTCGCCGACCTTCGACTCGGTGCCGGTCGGCTGGGAGATCCGCACGCGCACGGTGCCCTGCTGCACCCAGATGGTCTCGTGTCCGCCCGCGCCGTCAGGGACTGTGGTCCGCCGCCACAGCCCCATCGCCCGGTTGCGCAGGTGACTGGTCCGGTCCTCGCTCACCGGCCGGCCGATCAGCGGTCGGGCTCGATCACAGCGACCTGCAGCGCGGTGACGCCGGAGTAGGTGATGTTCGCGCGACCGACGCTGTTGCGGAACTCGTCGGTCAGCGGCAGCACCCACACGCCGCCGTTCTCGGTGATGGACTCGGCCACCTCCCCGATCGCGATGCCGCGCACCGTGCCGGGGGTGGACACCGTCGCGGTCTGCGCCGCGCTGTGTCCGTTGCGCACCAGCAGGATCCGGCCGCCGCCGCACGGCACCTCGTCGCCGCCGGAGCTGGCGTTCGTCCATGCGATCTCGACGCCGGCGGACACCGACGCACGCTGTGAGTTGATCAGCGCCATTAGGCACACTCCTTATCGGTTGGCCGTGTACCGGCTCAAGGACTTCTTGTCTGCTGTGGACAACGACATCTGCACGCGATCCCAGGCCACCTGGTAGTCACCGATGCGCTCGCTCTTCTTGCCGCCCTTGGCGTTGTCCCACTTGCCCGCCACCAGGTCGCACACGACACCGACCACGGACTTGGGGACCGGGTTGTGGCCGGCCGTGCTGTCGACCGTGACGCGCTTGCCGCACGGCCACACGCCGCACCTGCGCGTCAGCACACCACTCGGTTCCCAGGTGAAGTCGGTGCCGTCGACGAGGGGCGTCGTGTCTCCCTCGACCTGGACGCTGGCGACGGCCAGCACCGGCCACCGCGGTAGCACGAGCTCGCAGGTGCCGGTGCCGCGCAGCACGGTCGTCTGTGTCGCTACCTCCAGGTTCTGGCCGAGCTCGTCGTCGACCAGGCCCTGCGCCACGCCCAGCAGCAGCTCGGCGCGCGGGACCTGGGCGGTCGGCATCTGCTCACCCAGCCCCATCCACACGGCGAGCTCGTCGGGCGTGACGTAGGCCATCAGGTCCTCCGGCTGCGCCGAACGCGCTTGGCCTTGGCCTCGGCGTCGTCCAGCTCGGTGGCCGGCTCCTCGGTCGGCTCAGCCGTCGACGCGGTGCCCTGCCCGGCCGGCGGCTCCTGGCCGTCGCCCTGACCCTGGCCGTCGCCCTGGCCGTCGCCCTGGCCGTCGCCGTCGCCCCGGTCCCCGTCGCCGTCGTCGGGCTCATCGGGGAGGGTCAGCAGGCCCGCGTCGAGCTCGTCGCGCAGCGCGGCGAGCTGCTCGGCGGGAACGTGAACGTCGTTGCCCAGGCGGTCGACGGGGACCGCGAAGCCCTTGACGATCAGTTCCAGGGCCTCGGCGTCGGGCAGCACCGCGATCTGGTCGGGCTGCAGGCTGCGCTCGGGTGTGGCCGAGAGTGTCTTCATTCGGATGCGCTGCACCGGTACCTCCTATCCACGTGCGCGGACGGGCTGAGAGCGCCGGTGCGCGCTCCCAGCCCGCGTGCAAGGGGGTAGGGCTACTTGGGCAGCTTGCGCGGCTTGGCGCGCACCACGGTGGCCGAGCACGGCATGGTGGGCGTGGTGCCCGCCTTGGCCGTGATCGCCACGCGCAGGTAGCGCTTGATGCCCTTGTAGCCGACCTCGTAGACCGCCTCGTCGTTCGCCGCGGCGATCACCGGTTCGGTGCCGTCCAGGTCCGCGTCCGGCACCGCGGTGAAGACCGCGTTGTCGTCGCTGTGCTGCACCTCGAACGTCAGCGTCGCGCCGGCACCGGCGATGGTGCCGGCGTCGATCACCACGACCGCGGCGTCGTAGCCCGCCAGGTCGACGCCGATGCCGTTGACAGGCACCGCCGGGTCGGCCTGGCTGGCGGGGCGCAGGGTCTGCGCCACGCTCACGCTGTTGCGAATGTCGGTCCTCGACATGAGGATTTCTCCGTCCTGTGTGGAGTCGTCAGGGATGCCGGACTAGGCCGGGACCTTCAGGCGCACGAACGCCTCTTCGAGAACCGGCATGCCGTCGGTCTCCAGGCGGCCGATGAACCCGACCTGGTTGGTCTCGGCGTAGAGCTCCACCAGGCGCTGGACCTCCATGTTGAGCGCGTCGACGATCCAGTACTTGCGGAAGTCACCGAGCATGCCGACGTAGTTGTTGCCCGACACCGTGTTCGGGACGAACTCGCTGACCACGAACGGCAGGTCCAGGATCGTGTCCGGCTTGTCCGAGGAGATGCCCGGCTGCCACAGGTAGGTGTCGTTGGTCGACCCCTTGAGCTTGCGGATCGTCGCGATCAGCGTGCGGTGGAACAGCCACCGCGCCTCGGCCCAGTACGCGGACTTGAGCGTGTACTTGGCGTCGATCAGCTGGTCACCCGACACCGGCGTGAGCGGGATCGCGCCACCGGTACCGAAGCTGACGTCACGCGCGGTCGAGATGCCGTCGGTCGAGGCGGTGAACAGGCCGAGCGGCTTCTTGTTGCCGTCACCGGTCATGTACGCCTTCTCGCACGTGACACCGAACTTGTGGGCCATGCGCTCGCGCACGATGGCCTCGGGGTCGCGGGCCGCGGCGCGCAGCAGCTTTCGGGAGACCCGCACCCGCTTGGCCAGCGGGTTCGGGCGGAACTCCCGCTTGCCGAACCGCAGCGCGTCGTCCTGCGAACCGGTGCCGATCTCGCTGGTCCACTCCGCGTCGTTCAGGTCGGTCTCCAGCGTCGGCACGCCGAGCGACTCGCCCTCGTTGAGCGTCTCGACGGTGGCGAGCTGGCGCAGCACGACCAGGTCGTCGACGGCCTGGATCAGCTGGTTGACCCACTGCTGCGGGGCCACCAGGTACCCGCCTTCCGGGTCGTTGCCCATGTTGAGCGCGCGGGCCTCGTCCGGGCTCAGCGCGTTGCGGCCGCCGACCACGAAGTTGCGGAACGCGCGACCCCGCAGCGCCTCGTCCGGGTTGTCGTCACCGGAGCCGTCGCCGCGGGCCGGTGGCGTGGTGCCGGCGATCTGGCGCTCCAGCTCGCGGGCGCGTTCCTCGCGGGCGATGGTCGCGTCGATCCGGTCGGCGTCCGCCATCAGGCGGTCGAACGTCTGCTCCTCGTCCGCGGTGATGCTGCGGCTGGCGTTCTGCGCGGTGTCCAGAATGGCTCGCGCCTGAGCGGCCAGGTTGGCGCGCTGCTGCCGCAGGTCGTTGATGTCCGGCACGGTGTGCCTCCTCCTTGTGAGGGGTGTTGTGGGCAGCCGTCAGCGCGGGACCGGCCAGGGCCTCCGTGACGTACGGCAAGGGGTTCGGTGGTGCGAGCCGCCCAGCCAGGGGCGGCGGTGGGCCGGTCGTTACAGGCCGGACGCGAACAGGCGGCGGCGTGCCGCGATGTTGCGGTCGAACGTCGGCGGCTCGACCGGGGCGGGCTGCGCGCGCCGGCGCCGGGGTCACCGAGGCCGCCCAGCAGCTCGGCTGCCTCGCGCAGCAAGCCGTCGTCGGCGCGGCGCACGAGCTCGCGCGCCTCCAGCACCGAGCGGGCCAGCGTGAGCGCCGAGCGCCCGTCGCGGCCGTCCGCGGCGGTGGCGCCGGGGTCCATCGGCAGCGGCACGACGGAGATCTCGAACAGCTCCCACCGCGCGGGCACGCCGTCGGTGCCGATGTCGTAGGCGCTGAACCCGATGGACACTGCGTTGAGGTAGCCGCGGCGGATCTTGCGGTCCACGTCGGCGGCGAATGGGTCGTCGAGGTCGAACTCGAGGTCGGTCAGCAGTTGGGTGCCGTCGACGCGAGTCGTCGGCGCGCGGCCGATCGGCAGCGCCTGGCGCCCCCAGTAGTCGTGCCCGTACATGACGACCGGGTTGGCCGCGAACCGGGCGAGGTCGGCGGTGTCCATTCGCAGGTCGATGCCGTCGGCCATGCGACCTTCGTTCGCCGCGACGAACGGGATCGGCCCTTCCTCGGCGGTGGTGCCGTCGTCAGCGCGGACGGCGAACCCCCGCAGCCACACGCGGTTGCTGGTCATCGGTTCCTCCCAGGTGTGCGGACCTGCCGGTCACGCGGGGACTGTTGCGCCCGCTCACCGGGTCGCTCGGGGGTGGGCTCGGGCGGATCGAGCTCGTCGGCGGCCGCGCGCAGCAGCTGCCCGACGAACCGGCGGTCGAGCTCGGCGCCCGTGCCGTCGAAGGTCACGGCGCCGATCTCGTGCTCGGCGCCGGTGCCGGCGCGCATGTAGATGGGGATGGAACCGCTGGCCACTGTGGACACCTCCGTTCCTCGGTGTGGCTGGTCTCATGCCGGTGCCATTCCGCACCCGCATTTCGGGTGCAGCGGCGGGTGGCGGATCGTGCGCTTGACGGTCAGCCGCTCGACGCCGTCGCCGTCGAGCTCGTCGCCCTTGGTGGCGAACGCGTCGTCGATGGCGACCTCGCGGCCGTCGAGTGCGACGCAGTACGGGCACGAGTCGCCGTCGGTGACCCACCGCACCGCGGGGACACCGGCGGCCTTCCAGGTCTCGCGGGCGGTGGCGTTGGGCAGCTGGCTGGTCTGCCAGTCCGCCGTGCGCTGCGGCCGCTCGTCGACCCAGGTGTCCAGCAGCGCGAGCACCGCGGCCGCCGCGGCGTCACCGTCCTCGGTGCCGGCCTTCTCCAGCTCCGCGCGGATCTGCCCGTACGCGGAGTTGACCCGGTAGTCCGCGTGGCTGTCGACGTAGGCCGCCAGCCACCGGGACAGGTCGACCTCGCCGTCGAACCCGACGTCGGCGATCGCGTCGGCGATGATCTCGACCATCAGCGCCTGCAGCGGCGGCGTCCACCGTTCCACGGTCTTGGCCCGGATCGTCGTGTCGTACAGGTGCCACACCGCCGCCAGGAACGCCGCCGGGCTCGCCAGCCGCACACCGCGGCCGTCGTCGTCGGACAGGTGCCGGCGTACCAGCGCCTTGACCTCGGCGCGCTCCAGCTTGGCCAACCGGGTGTCCGCGTCGACGATCAACGGGGCGAACGTCGAAGCGGTGCGCCGGCGTGCCTCCGCACCACGACCACGCAACACCCGCGCGATCCGCTCCGGAACAGTCGGCTCTTCGTCGGGGCGCGGCGCCGGCACCATGTTGAGTGGCACCAGGTACACCTCGCCGCGGCCGTCGGGCAGCGGGTTCATGTTCTCCCGCTCGCGGATGTCGTCGGCCGACAGCCAGCCCCAGTTCCGGCCGATCGCGTAGGCCTCGTTACGTGACTTGCTGTCACCGCGCAGCAGCGCGTCGACGAGGTGCTCGGAGAAGTAGCGACGACGCTCGGCCATCGTGAACAGCCGCATAAGGATCGCCTGCTCCCAGCGCACCAGCCAGATCCGCAGCGTCGAGGTGACGTACTCCAGGCCCTGGTGCTCGATGTTGCCGAACGTGGCGCGTTCGAGGTCGGCGATCTTGTGCGGCGGGATGCGCAGCCACCGGGCCATCTCGGTGACCTGGAAACGCCTGGTCTCCAGGAACTGCGCGTCTTCCGGCGGGATGCCGATCTGGTGCCACTCCACCCCCTCCTCCAGGATCGCCACGCGCGAGGCGCGGTCGAGTCCCCTGTGGAGGTTCTCCCAGTCCGTCCGCATGCGCTCGCGCGCACCCTCCGACAACTTGCTCGGGTGGGTCAGCACGCCGCCAGGACGTGAGCCATTGGCGAAGAACGCCGAGCCGTAGCGCTCGGTGGCCATGCCCAGCCCGATCGAGCCACGGGCCAGCGACACCAGGCTGTAGCCCTCGACGCCGGTACCGCCCAGCCCGGCGACCGGCAGCACCTCGTCGGGCAGCAGGATCACCTGCCGGCCGTTGGGGTCGGTGTACCGGTAGTACAGCGTGAACTTGCCGCGGCCGTTGGCGTCGTGGATCTTGCAGGGCTTGATCTTGGCCGGGTTGAGCGGCCACAGGCTGTCGACCTGCCCGGCGCCGTTGCGCTCGATGTAGGCGTACGCACCCTTCCACGTGAGTGCGTGGCCCTGCATGGTCTCGCGGAACGCCACGGCGGTCATGTACGGGTTCGCCTGGTCGTGCAGCACCTGGTACAGCGGGTGGTCGAACGCGCGTCGCTTGCCGCGCTCCAGGCGCTCGTAGACCGGCAGCGGCAGGCCGCCGATGTCACCGGCGATGATCTGCACGCCGGCGAAGAACGGGGCGTAGTGCAGGGCCGTCTCCTCCGAGACGAACGCCCCGGACGGGTTGTGGCTGCCTCCGCCGGCGAACCAGTCCTCGACCCACTTCTCGGGCGTAGCCAAGCTGGAGGTCGACGAGCCGCGGAAGGCCGAGCGGACGAATCCCACGATCAGCCTCCCGCCTGCAGCTCGTCGACGACCGGCTGCTGCCGGGCGCCGGTGATGCCCAGCGCGAGCACCAGGCCGCCGAACACGGTCAACGCCACGCCGATTCCGATCGCCACGCCCAGCCACGTCCCGACCGCCAGCGACAGGCCGAGCAACAGGCACAGCAGCCCGACGGCGCAGCAGTAGTCCCAGCGGTCCAGCTGCGCGCGGTCGACGAGCTCGGCCAGGCGGCCGCGCTCGCGCGGTGCGTCCTCGACGCCGTGTGGCACGGCGAGCTCTCCGGGCACGGTGGGCTCCTCTCATCCGAGCGAGCTCAGCCCGCGCTCCTCGTAGACACTGCGGGCGTCGCCGCCGCGCATGGCGCCGTCCTCGGCGAAGAACAAGGCCGGCATGCCGTCGATCCGCTTGTGACTGGTGTCGCGCATCGGCTTCACCGGCCGGATCCGCTCCGGGTCGTCGGTGGGGTGCTTGGCCTCCAGGCAGTCCGCCATCCACGCGGCGACCGGGTTGCCGTGGTGGCGGTACTCGACGGCCTTGAGCTTGCGCATCGCCTCCTTCATCGGAGGCGTCATGCGCTCGTAGGTGGTGTTCGACTCGACCATGTCCATGCCGGTCAGTTCCTGGATCGTCTGGCGCACCGGCTCACCGGACCACTTGTCGTAAGTGCCGGACACAATCACGTACCGCTCGTGGTCGCGGGCGATGTCCTCGTAGATCCGCTGATAGTCGATCGTGTCGCCCTCGGTGACGGTGACCCACCCGTCATCGCACCACTGGCCGAACTTGTCGTCGGTGTGCTTGTCGAGCACGTCGACCATCGACTCGGGGATCCAGAACCTCCACAGCAGGTCGCCGTCCTCGAACCTCAGGCACCAGGCCGTGAGGTCCAGTTTGGACGACAGGTCCAGGCCCGCCCAGCACCGCTTGCCCTCCAGCTGCGGCACCAGGTCCTCGGGGATCTCGGCGACCTCACCGGCGTTGGCGTTCCACAGGTCCAGCGCGATCCACCGCACGGCGTTGGCCTCGCGCATGTTCAGCTTGAACTGCCGGAACGCCGACTCCGCGCGCTTGCTCTTCTTGGCGCCCAACGCCGATCGGCGCATCGCCTCCAGCGACAGGAACTCACCCAACGCCGGGTTGGGCCACTTCCAGTTGCGTTCGTCCCAGATGTCCAGCGACACCGGCAGGTCCGGGTGCCCCTCGAACAACCGGTGCAGCCGGTCGAGCTGGTCCTGGTTGGCCGGCATCTTGCGGCAGAACACGAACGTGTGCGGCGACCGAGACGGGTCCTCCTGGATCCGCTCGGCCTCGTCGATCATCGCCGCACCGAAGCTCAGCGGCAGGTTGGTCTCCGTCGTCGCGACGAACAGCAGCTCCTGCAGCCGTGCGCCGTCGGCGGTGTCCATTGCGTCCCACAGCGACGCGTCCGGCTGCGACAGCAACTCGTCCAGGCAGAACCCGGACGGGTTGTGGCCGAGCTCGCCGTCGGCGTCCGCGGTGATGACCGTGAACACCGAGTCGGTCTTGGCGTCGACCAGCCGCATCGAGTTCTTGATGTGCTGCAGCCGCTTGCGCAGCACCGGCGACAGCTCGACCATCCGCCGCGCCGGGCCGAAGATCTTCTGCGCCTGGTCCTTGTCCTTGGCCGCGGTGTAGACCTCGGCCGACTCCTCACCGTCACCGACGAGCAGGTAGAGCAAGATGCCCGCGGCGATCTCGGACTTGCCGTTCTTGCGGGACATGATGATGAACCCGCGCCGGTAGCGGCGCACGTAGCGCTGCCACTCGTGCGACCACACCACCTCGCCGAACAACGGCCTGATCAGCTCGTGTTCCTGCCACGGCCGCAAGACGAACGGCTTACGCCGCAACGCTCCCTTGACGTGCCGCAGGTGCTCGCGGAAGAAGAACACCACGCGGTCCGCGCGCGGCTCGCAGTAGTGCGCGCCCCGCTTGCAGCAGATCTTGCCGCGCAGCTTGTAGCCGCACACCGGGCCATCGGGGTCGATCGGCCGCCACCGCGAGTCGTGAAACTCGGCGATGGCGTCCGCGGCGTCCGCCTCAGCCGTGGTCGAGGAGGTCCTCTCCTGGCTCACCGGGGGCCTCCCCGAGGCTCAGCGCCGAGCGGTCGGACGGCGTCAACCCGAACCTCGCGGCGTAGTAACGAAAATGCGCGTCCGCGTCGTTGAGCACGTACGTCCACGGGTTCTTCCCGACGCGCGTGCCGGTGGGCTGGCCGTTCTTGTTGTAGACGGTGAACTCGCGCACCGCGCCTTCCTTGCGCAGGTGCTCGATCGCATCGCGCCGGCGGACGACCGCGTCGCACCAGGCCGCGAACGCCTCGACGTCCCACAGCGTCAGTACGCCGACCAGGTGCAGATCGGGGGCGTACTGGCGCCACACGTTCTTCGCGCGCTGCGTGAGCCACGACGGCGGATCGATCGGGCAGTCAGCGCCACCGTCCGCGGGCGGTGCCTCCGACGGCTGCGGCTCGTTGGCGTTGATCCGGTCCGTGCGTCCGCCCATCAGGACAGCCCACTTGGTCGGCATCCTCGCCGGTCCACGCTTACCCACAGTCACCACCTCCTGGGTACGGTCGGACCGAAAACCTGTCAGCGCGCAAGCGGGCTTCCCCCCGCACGTTCGCGTCCCCACCCCACAGAGATCCGAGCCCCCCTCCCCTTGATCAACTTCGTTGATCGATCACAGGGAGTGAGCATCAGGGGGAGGGGGGTAGGCCGCTCCGCGGGGCGGTACAGCTCGTGCTCCTTACCGTGGTGTGCGCCGGTTGCCGAACCCGCCGTCGTGCGTCGCCGTCTTGCGGCTGTGGCAGGACAGGCACAGCGGCTGCAGGTTGTCCGGCTCCCAGTTGGTGCGGTCGCCGTCGATGTGGTCGGTGTGCTGCGACGGCCGGCCGCACGCCACGCACGTGGGGTTGGCGCGCAGGTAGGCCTCGGACTTCTTGCGCCACCGGTAGTCGTAGCCCAGCGCTGTGGACGACGGCCGCGGCTTCGGCTGCGGACGCGGCCGCGGGATCTCGTGCTGTTCGCACCGGCCCGAGGTGCCCGCGAATCCTGGACACCCGGAGGCCGTGCAGCGTCGGCGAGCTCTGCTGGGCAT

Protein sequences of DBSCAN-SWA_1

>NZ_CP016793|973760:991068|979833_980205_-|WP_065920821.1|DBSCAN-SWA
MSTLLSRDEILSAVDITTEDVDVPEWGGRVRVRGLTGTDRDRFESAMLNRNGKGNARHQVNTDNFRARLVMASVVDEDGRRMFSERDVRALGEKSAAALDRVMTVAMRLSGLTQKDADELEGN
>NZ_CP016793|973760:991068|980270_980684_-|WP_065913941.1|capsid|DBSCAN-SWA
MAGLDAFGTQFLTGDGGSPEIFTPIANCTNVGGPETERATHDVTAHDSPDGWREFIGGLKDGGEVSLELHYDPRDHDALYEHYEDSQPRTYRILWPEGLGGWQIKAVMTGFSSEAPFDDKLSAEVTFKVSGKPTLLV
>NZ_CP016793|973760:991068|985932_987948_-|WP_065913949.1|portal|DBSCAN-SWA
MGFVRSAFRGSSTSSLATPEKWVEDWFAGGGSHNPSGAFVSEETALHYAPFFAGVQIIAGDIGGLPLPVYERLERGKRRAFDHPLYQVLHDQANPYMTAVAFRETMQGHALTWKGAYAYIERNGAGQVDSLWPLNPAKIKPCKIHDANGRGKFTLYYRYTDPNGRQVILLPDEVLPVAGLGGTGVEGYSLVSLARGSIGLGMATERYGSAFFANGSRPGGVLTHPSKLSEGARERMRTDWENLHRGLDRASRVAILEEGVEWHQIGIPPEDAQFLETRRFQVTEMARWLRIPPHKIADLERATFGNIEHQGLEYVTSTLRIWLVRWEQAILMRLFTMAERRRYFSEHLVDALLRGDSKSRNEAYAIGRNWGWLSADDIRERENMNPLPDGRGEVYLVPLNMVPAPRPDEEPTVPERIARVLRGRGAEARRRTASTFAPLIVDADTRLAKLERAEVKALVRRHLSDDDGRGVRLASPAAFLAAVWHLYDTTIRAKTVERWTPPLQALMVEIIADAIADVGFDGEVDLSRWLAAYVDSHADYRVNSAYGQIRAELEKAGTEDGDAAAAAVLALLDTWVDERPQRTADWQTSQLPNATARETWKAAGVPAVRWVTDGDSCPYCVALDGREVAIDDAFATKGDELDGDGVERLTVKRTIRHPPLHPKCGCGMAPA
>NZ_CP016793|973760:991068|988247_990044_-|WP_083267793.1|terminase|DBSCAN-SWA
MSQERTSSTTAEADAADAIAEFHDSRWRPIDPDGPVCGYKLRGKICCKRGAHYCEPRADRVVFFFREHLRHVKGALRRKPFVLRPWQEHELIRPLFGEVVWSHEWQRYVRRYRRGFIIMSRKNGKSEIAAGILLYLLVGDGEESAEVYTAAKDKDQAQKIFGPARRMVELSPVLRKRLQHIKNSMRLVDAKTDSVFTVITADADGELGHNPSGFCLDELLSQPDASLWDAMDTADGARLQELLFVATTETNLPLSFGAAMIDEAERIQEDPSRSPHTFVFCRKMPANQDQLDRLHRLFEGHPDLPVSLDIWDERNWKWPNPALGEFLSLEAMRRSALGAKKSKRAESAFRQFKLNMREANAVRWIALDLWNANAGEVAEIPEDLVPQLEGKRCWAGLDLSSKLDLTAWCLRFEDGDLLWRFWIPESMVDVLDKHTDDKFGQWCDDGWVTVTEGDTIDYQRIYEDIARDHERYVIVSGTYDKWSGEPVRQTIQELTGMDMVESNTTYERMTPPMKEAMRKLKAVEYRHHGNPVAAWMADCLEAKHPTDDPERIRPVKPMRDTSHKRIDGMPALFFAEDGAMRGGDARSVYEERGLSSLG
>NZ_CP016793|973760:991068|990009_990474_-|WP_170067868.1|terminase|DBSCAN-SWA
MGGRTDRINANEPQPSEAPPADGGADCPIDPPSWLTQRAKNVWRQYAPDLHLVGVLTLWDVEAFAAWCDAVVRRRDAIEHLRKEGAVREFTVYNKNGQPTGTRVGKNPWTYVLNDADAHFRYYAARFGLTPSDRSALSLGEAPGEPGEDLLDHG
>NZ_CP016793|973760:991068|976203_977091_-|WP_154697075.1|DBSCAN-SWA
MMAAGDLITVTDPTQTQVEWRGLLLGHGTRYRMTGLEGWVDSDDIRDGDVELDNEHGAHPGQLLLARKVVTFEGHIAGPSGFTDAVNELRRVTTQSENPDEEPLVVHTAGIKAMVNARCVGRIIPQHLEWISGFTRIVLRWRATNPRMLRLPQLAPVASPPVSGGGGLIFPLVFPLRFGGAPSGGELVLANDGHAHAQPVWRITGPCVGPMITNADTGARLWFEPDFALNSGERLDLSTEDKSVLYADTSPPVSRSNQLAVREWFTLPPGTSTRVRFDTVDGNGTLTCLYHHTDL
>NZ_CP016793|973760:991068|977090_979454_-|WP_065913939.1|DBSCAN-SWA
MATLASLMVSLGLDPKKLRSGAAKARKYVDGVRADVERTNAVLSKMEAPIAALGKVGSLALLAKGAVVAKAAVAPLSGALFALPAAAGVAVGAMATVKMATAGVGEAMDALASGDAAAAQEALSKLSPAARSFVREMHATKQAFKPVQQMVQQRFFDRLGGDVSAVAKGHLPGLRAGLGETAGQLNGLAREALNASNTPFMHGVVADVLARTAKVIGLFKPAVGPAVTAIGAMAKAGMPLVESFGAWAAKGLQAKAAFLGTAEGATWLDQKVAAAQTTIGQLVAIAGNVRAVLSGLFGPANSGGTSLLAIVQNLTARMAAWVNSASGQERIAQVWDMITQAGHTIVEVLPLMIGPLGVLLGLLSSMDPQTQAVVASVLAWSVLLGPLAGKVIALVSALVQIYRAVPAVWAMAKAMWSGITTAASWVATHTAAAARTVAAWIAASARTVASLAVMAAQFVAQGAVIAASMAAHVARVVAGWVLMGVQALANAARMAAAWLIAMGPVGWVIAAVIGLVALIIAYWDEIAAATAAAWEWVSNAVSSAVDWVVNWVKSNWKLLITIILGPLGAIIALVVAHWDRIKSAFQSGVDTAISIFQWLGRLPGMVGGWFRGIYDAAVGKALELVSWLNGLPGRILGAIGDLGSLLLGAGRSVIDGLLRGISAGFQKVKDKLNELTNLLPDWKGPAVVDARILTPSGELIMQSLVDGFSRGQAQVERYLEGFTAGIGEVSIPTPRVPGLSMAVSGAAPAAEQRRERALVHIDNYHPPADASPHEVAEDLDWFSRGGG
>NZ_CP016793|973760:991068|980686_981028_-|WP_065920822.1|DBSCAN-SWA
MAAVSGVYDQVPEPAAFPYIRLGDTTEVPDDNHSRRGSRVTTTLHIFSRYRGNKQGLQILGQVDRLLDRQALLVPGYRDVSCAREFHQTLRDPDPEIRHIPVRYRLWLTREDP
>NZ_CP016793|973760:991068|974945_976190_-|WP_065913937.1|DBSCAN-SWA
MGERYSWAVGIDETEGVITVEDARLAMSAFWTPAGQIVSRSGVVPAASEPGRVTATTPTPNGFVHIAPFRAVLQSVRGGGTYNVCLDSVKDINILSTPADPSNPRIDLIVWQQSDTYFGDANSNFTVRHVVGAAAPVPVDPAVSGSTDYIIRARVTVPAGTTDIEQADIANVTLPWTVATGGLLPIRTQAERDAILLPYEGMPIYRTDRDWVEIYDGGAWRVHGVAICTSVADRNAAITHPRTGQLTMITDIDCLWQYDGATSAWVPIGGGVPQAQLRQTATQTLTTGVGAPINFQVEDRDNFAGHDNVTNNSRYTAQVPGWYELNGGIAFAASGVGARVSQWNKNGAMIDGSDLAFPSAGAGLATRIPARTTQVQLAAGDYVQLVGFQDSGGPLDTFTGGGVRSSMSVKFVGT
>NZ_CP016793|973760:991068|981452_981698_-|WP_083268712.1|DBSCAN-SWA
MWVQQGTVRVRISQPTGTESKVGDTEQGELTHQVYDEPGSPIRRGDELRDAALTLRVMRVLAPSEAIYLRADCEEQQPERG
>NZ_CP016793|973760:991068|979486_979780_-|WP_065913940.1|DBSCAN-SWA
MTVKELLARIDSSELVEWQIYERMTGPLGAGRHDYLTAMVTSAVVNSQRGKKPPVALKKFVPQWERPTLTPAEMFARIREINNALGGIERPIEDGFD
>NZ_CP016793|973760:991068|990717_991068_-|WP_065913952.1|DBSCAN-SWA
MPSRARRRCTASGCPGFAGTSGRCEQHEIPRPRPQPKPRPSSTALGYDYRWRKKSEAYLRANPTCVACGRPSQHTDHIDGDRTNWEPDNLQPLCLSCHSRKTATHDGGFGNRRTPR
>NZ_CP016793|973760:991068|981087_981447_-|WP_154697076.1|DBSCAN-SWA
MGANLKGDKQLLRDVAELQKKIIEAGGDAVEAWGEDVKGTAQNRVPIDSGNLGSAIESRPDRKRLKCDVGVWEEDAYYAEFVEQGTQSMYAQPFLVPAFEQHADVTPYAKGALAKRLDS
>NZ_CP016793|973760:991068|973760_974903_-|WP_065913936.1|DBSCAN-SWA
MALPVYRYQIADLATNRILEDVRLTGVSFNKPLNGSGRFDATWKLGAKTRHLDAYDLTMPTRRCIYAWRDDRPMWGGIIWTRKYSSTSQTVTIGAGEWWSYFDHRAVLPLLPASPGIFDLAGLAAPSYAGIDQNQIARNLVALAQSHTGGDIGIRLDLDTTTSGQLRDRTYPPYKLSNAGEMLRNLTGVIGGQDMVFDVAASSTGAAAPDRVLLQGTPWLGQQGSSHVWELTGSATSYEWDSDGTRMATRAYAVGEGVDLGTPIAVSEDSSKYAIGFPLLELDTSYDGDDPDVLGAHAQGDQEAARLPVVLPRFVVRGDVPPTAADVSRGDDGRLIIPAGDLFHRRGWDGPVRVVDIKYSPSASAERLEITAAPMLDDVA
>NZ_CP016793|973760:991068|981802_982135_-|WP_065913943.1|DBSCAN-SWA
MALINSQRASVSAGVEIAWTNASSGGDEVPCGGGRILLVRNGHSAAQTATVSTPGTVRGIAIGEVAESITENGGVWVLPLTDEFRNSVGRANITYSGVTALQVAVIEPDR
>NZ_CP016793|973760:991068|987950_988235_-|WP_065913950.1|DBSCAN-SWA
MPGELAVPHGVEDAPRERGRLAELVDRAQLDRWDYCCAVGLLCLLLGLSLAVGTWLGVAIGIGVALTVFGGLVLALGITGARQQPVVDELQAGG
>NZ_CP016793|973760:991068|983636_984866_-|WP_065913947.1|capsid|DBSCAN-SWA
MPDINDLRQQRANLAAQARAILDTAQNASRSITADEEQTFDRLMADADRIDATIAREERARELERQIAGTTPPARGDGSGDDNPDEALRGRAFRNFVVGGRNALSPDEARALNMGNDPEGGYLVAPQQWVNQLIQAVDDLVVLRQLATVETLNEGESLGVPTLETDLNDAEWTSEIGTGSQDDALRFGKREFRPNPLAKRVRVSRKLLRAAARDPEAIVRERMAHKFGVTCEKAYMTGDGNKKPLGLFTASTDGISTARDVSFGTGGAIPLTPVSGDQLIDAKYTLKSAYWAEARWLFHRTLIATIRKLKGSTNDTYLWQPGISSDKPDTILDLPFVVSEFVPNTVSGNNYVGMLGDFRKYWIVDALNMEVQRLVELYAETNQVGFIGRLETDGMPVLEEAFVRLKVPA
>NZ_CP016793|973760:991068|982689_983094_-|WP_065913945.1|DBSCAN-SWA
MKTLSATPERSLQPDQIAVLPDAEALELIVKGFAVPVDRLGNDVHVPAEQLAALRDELDAGLLTLPDEPDDGDGDRGDGDGQGDGQGDGQGQGDGQEPPAGQGTASTAEPTEEPATELDDAEAKAKRVRRSRRT
>NZ_CP016793|973760:991068|985662_985899_-|WP_065913948.1|DBSCAN-SWA
MASGSIPIYMRAGTGAEHEIGAVTFDGTGAELDRRFVGQLLRAAADELDPPEPTPERPGERAQQSPRDRQVRTPGRNR
>NZ_CP016793|973760:991068|983186_983594_-|WP_065913946.1|DBSCAN-SWA
MSRTDIRNSVSVAQTLRPASQADPAVPVNGIGVDLAGYDAAVVVIDAGTIAGAGATLTFEVQHSDDNAVFTAVPDADLDGTEPVIAAANDEAVYEVGYKGIKRYLRVAITAKAGTTPTMPCSATVVRAKPRKLPK
>NZ_CP016793|973760:991068|982147_982690_-|WP_065913944.1|DBSCAN-SWA
MAYVTPDELAVWMGLGEQMPTAQVPRAELLLGVAQGLVDDELGQNLEVATQTTVLRGTGTCELVLPRWPVLAVASVQVEGDTTPLVDGTDFTWEPSGVLTRRCGVWPCGKRVTVDSTAGHNPVPKSVVGVVCDLVAGKWDNAKGGKKSERIGDYQVAWDRVQMSLSTADKKSLSRYTANR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065913936.1|973760_974903_-	hypothetical protein	A0A1J0MCD8	Streptomyces_phage	8.6e-22	26.2
WP_065913937.1|974945_976190_-	hypothetical protein	NA	NA	NA	NA
WP_154697075.1|976203_977091_-	hypothetical protein	NA	NA	NA	NA
WP_065913939.1|977090_979454_-	hypothetical protein	Q1WDF5	Streptomyces_phage	4.2e-15	36.4
WP_065913940.1|979486_979780_-	DUF4035 domain-containing protein	A0A2P1N0I8	Streptomyces_phage	2.1e-12	37.9
WP_065920821.1|979833_980205_-	hypothetical protein	D7NW62	Streptomyces_phage	8.6e-24	52.5
WP_065913941.1|980270_980684_-|capsid	outer capsid protein Hoc	D7NW60	Streptomyces_phage	1.3e-41	61.0
WP_065920822.1|980686_981028_-	DUF3168 domain-containing protein	D7NW59	Streptomyces_phage	3.3e-22	47.2
WP_154697076.1|981087_981447_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_083268712.1|981452_981698_-	hypothetical protein	NA	NA	NA	NA
WP_065913943.1|981802_982135_-	hypothetical protein	D7NW57	Streptomyces_phage	5.5e-14	45.8
WP_065913944.1|982147_982690_-	hypothetical protein	A0A142K635	Streptomyces_phage	3.1e-22	36.1
WP_065913945.1|982689_983094_-	hypothetical protein	NA	NA	NA	NA
WP_065913946.1|983186_983594_-	hypothetical protein	A0A142K633	Streptomyces_phage	8.6e-17	47.4
WP_065913947.1|983636_984866_-|capsid	phage major capsid protein	A0A142K632	Streptomyces_phage	2.0e-125	57.0
WP_065913948.1|985662_985899_-	hypothetical protein	NA	NA	NA	NA
WP_065913949.1|985932_987948_-|portal	phage portal protein	A0A142K630	Streptomyces_phage	3.5e-188	51.6
WP_065913950.1|987950_988235_-	hypothetical protein	NA	NA	NA	NA
WP_083267793.1|988247_990044_-|terminase	terminase large subunit	A0A142K628	Streptomyces_phage	1.7e-210	61.8
WP_170067868.1|990009_990474_-|terminase	phage terminase small subunit P27 family	A0A142K627	Streptomyces_phage	1.9e-36	52.0
WP_065913952.1|990717_991068_-	HNH endonuclease	A0A2D1GNP5	Pseudomonas_phage	2.0e-06	31.5

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NZ_CP016793|5038097:5093795|DBSCAN-SWA
TGTGTTCCTGCGCAAAACAATTGCTGTGGTTGCCAGCGCTGCCGCCCTGTCAGTCGGCCTCGTTGGAACCGCGGAAGCTGCGCCCCGCACCCTCACGTACAACTCGAGCGGTGCCGGTGAGTTCCAGGCCGCCGTCGACCGCGGCGCCCAGGTGTGGAACAACAGCGTGGTGAACGTGCGGCTGGTCAAGGTGACCGGCGCCGCGAACATCACCGTCACCGTCGACAACCAGTGGCCTCGCGCCTACGTCACCAGCCTCGGCCGCGGCCGTTGGGTCATGGGTCGTCAGGCGGTCAACGAGGGCCACGACACCACCCGCATCTCGTCCCACGAGTTCGGGCACCTGCTCGGTCTGCCCGACCGCAGGACGGGGCTGTGCACCGACCTGATGTCCGGTGCGAGCGCCGGCACGTCGTGCAAGAACCCCAACCCGAACACCAGGGAGAAGGCCGAGGTCGAGGCCAACTTCCGCACCGCTGTGACGGTCGGCCCCTCCACGTACGTGGACGCCGCCTAGTTTCGAAGCGCACGCGGGGAGCTTTCGTACTCCAGAAGCGCACGAAAGCTCCCCGCGTGCGGTCAAGAATCAGTCGATCGGGTGACGATGAGGTCCACGCCGAGTGCGTGGAGCTCGTCGGGGTCACCGGGGCCCGCGATCACGTGCACGCCGGCCGAGCGCAGCAGCGGAACCATCAGCGCGAGTCCCTGCCTCGCGAGTCGTTCCGGTGGCGGCTCGGCCAGCCGCACGCCCCACACCGCGTTGCGATCCACAGTGGACAGACCGGCGAACCCGCCGCCGAACTCGTGCAGCAGCACGCGCACACCCATGTCGTGCAGCACTTCCAGGTTCTCCTCGCCGTCCGGCATCGCCCGCACGTCGAGCGCCAGGAACAACGACGAGGGCTCCAGCGCGCAGTCGCGCAACGCCGACCGCACCAGCGCCGCCAGGTCCGGGTCCCGCGACAGGTCGCGCGACAACCTGATCAGCACCGGCTCACCGCGGGAACAGGCGTCGTGCAGCACCAGCTCACCGACCCGCGCGGCCAGCCCCAGCGCGTCCGCGTGCGCCACGCACTCGTCGTGCCGGGTCTCGCCCCACCGCAGCGACGCCTCCACGAACGCGAGACCACCCGCCGCCCACGACACCGGCGCGTACTCCACGGAGATCTCGCCGTTCTCGAAGGCGCCGGGCATCGCCGCGATCCGCGCGAACCTGGCTCTGTCCGAGGCGTCGGCCTCGTGGTCGTAGATCGCCCACTGCCGCTTGCCGCCCGCCTCCGCGCGCCGCAGCGTCGAATGTGCCCGCCGCAGCAACGCCGTCGCGGTCACGCCGGATCCTGGAGTGTGCACGAAACCGATCGACGTCGACACCGCCACCCCGGCGCCTTCCAGGTAGACCGGCTCCGCCAGTTCCTCGTCGATCATCGCCGCCAGCGCCGCGACGTCGGGCGAACCCTGGACCAGCACCACGAACTCGTCACCGCCGATCCGCGCCACCACGGCGTCGGGCAGCACCGCCCGCAGCCGCCGCGCCACCTCGACCAGCACCGCGTCCCCGGCCTCGTACCCCAGGCCGTCGTTGACGATGGTCAGGCTGTCGACGTCCAGGTACGCCAGGGTGCACGGCTCACCGCTCGCGAGTGCGCCCTCCAGCCGGTCGACGAAGCTCGACCGGTTCGGCAGCCCGGTCAGCAGGTCCGTCAACGCCTGCCGGCGCAGCCACTCCTGCAGCATCCGCTGCTCGGTCACGTCCTCGATCAGCGCGACGTGGAACTTCGGCAGCCCGTCGGAGCCGCGCAGCACCGACAGCACGGCGTTGGCCCACACCGTGTCGCCGTTCTCGCGGGTGAGCTCCCACTCCCGCCGTTCGGTGTCCACAGTGGACTCGATCATCCGCTTGAACGCCGCCGCGAACGCCGTCAGGTCCTCGTCGGTGAACAGCTCCCTGGGCACCTCCTCGTGCCCCATGATCGTCGCCATCGCCTCGTTGGCCTCGACGACCGCGCCGTGCAGGTCGAAGATCGCGATGCCGACCGCGGTGGAGGCGAAGACCTGGGCGAAGCGCGCCTCGCTGTCGTGCAGGTCGCGCTGGGCGTCCTCGACCGCCTTCAGCAGCGAGTTCTTCACCTTCTCCTGCTCGGCGAAGATCTGCTCGCGGGTGGCGCGCACGTAGCCTGCGGCGAGCCCGCCCAGCACGTCGGGCCCGAACTCCGGCGACAGCACCTCCAGGGTGCGCCGCAACGAGTCCGGCCCGGTGAAGCGCGCGCCGACGAGCCACTCGCCGACGCTCTCCGGCGTGTCTGCCCAGCGCGCAGCCGGGCGGCGTGCTCGTCGAGGAACTGCGTGACGGTCCGCCGCGACATCGGCGAGTACGCGCTCTCGATCAGAACAGCCGCCCACCGCTGTGCGAGGGGCGAGGTGGCCATCAGGGCTTGCGGCCCACCGCGGCGTAGAGGTTGGCCTTCGACGGGTCGGTGCCGACGTCCTCCGGCGTCTCCGGCCGCCACTGCGGCGTGAACACGATGCCGGGCTCGACGATCTCGGTGCCCTGCAACATGTCCGTCACCTGAGCCTTGGTGCGCGGCGTGATCGGCTCCGCGGTCTTCGCGAAGATCTCCTTACCCGCGGCCATGGCGGCGGGCATGCTGTCGGCGGTGAAGTGCGACAGCGCGAGGTACGAACCCGGAGCGAGCGCTTCGACGTAGCGGGACAACACGCCCCACGGGTCGTCGGAGTCCGGGATGAACTGCAGCACTCCCACGACGAGCAACCCGACCGGCTGGGAGAAGTCGAGCAGCTCGCGCGCCTGCTGCACGACCTTCTCCGGCTCGCGGAGATCGGCGAGCAACGCGGTCACGTTCGGCTCGCCGGCCAGCATCAGCTCGGCGTGCGTGATCGCGACCGGTTCGAAGTCGACGTACACGACCTTGGCCCCGGGGTCGACCTCGTGCGCCACCTCGTGCACGTTGCCGACCGTCGGGATGCCCGAGCCCAGGTCGAGGAACTGCCTGATGCCCAGCCCGGCCAGCTCCAGCACCACCCGCCGCAGGTACGCGCGGTTGCGCCGGGCCATGTCCCGCACCGGCAGGACCTTGATCAGCGCTTCCGCCGTCTCGCGGTCGGCTTCGAAGTTGTGCCCGCCGCCGAGCAGGTAGTCGTAGATCCGCGCCGAGCTCGGCACGTCGACGTTGACACCTTCCGGAACCCAGCTGACTCGATCGACCACAGCAGCACACCTCTCGCGATGCGATTTCTGAGCGTCGACAACCCTACTGGCCGCAGTTGTAGGCCGAACGAGCGAAATCCGCGATCGGTCGAATGGCGAGTCAGAGGATGAACCAGTCGGTGGAACCGCCGGCGAACCGGAACTTCACGGGCCCGCGCGGCCCCGGTCCCATCACGAACATGCCCAGTTCGTCCACCGGCGCCGTTTCCACGTCACCGGCGGGAGCCACCAGCGTCACGTCGCCCGCCGCCGGCATCAGCTGCCCGGTGACCCCGGCCGCCGACACCTCCACCTGCAGCGTCACGCCGTCCGCGTCGAACACGAGCTGGCGCGCGGTGGACGTCGACCTGGCGCGGGCGAACAGCGTGTCGTCCAGCACCGAGTCGTAGGAGGTGATCAGCAGCAGCTCGGCGTCGACGGTGCGCCAGGTGAAAGCGGCCTTGGCCGCCTCCACGAACTCCGGTGGCACGTCGCTGGAGGGCGGTGTGCTCAACGCGTCGCGCAAGGCGTCGAGCAACACCTCGTCACTGTCCCAGTCGTGCCGCACCCAGCACACCCCCTCTCACCTGTGGCTTCCGTTGGGCCGGCGATCCCAGGAAGGCGGAGATCGCCGAGGTCTTGCGCAGTTTCTCCAGGCACCGGATCCGGGTGGGCCCGATGCTGCCGACCGGCATCGCGAGCTCTTCGCTCACGACCTGGTAGCTCGGCGGCGGATCGGTCATCAGCTTGGTCAGCAACCGCTTGCACTGCTCGGTGAGCTCGGCGAACCCGTCGCGCAGGGCCTGCCGCCGCTCCACGGCCAGCAGGTCGGCGTCGGCGTCGGAGTCCTCCGCCGACTCCAGCACGTCGGACTCGGTCAGCGGGTCGTAGAGGTGCGTCCGCTGCTGCACCCGCAACACGCGCAGGCACTCGTTGCGGGTGGTCGTCATGATCCAGCCGGGCAACGCCTCGGGCTCGCGGAGCCTGCCGATCTGCTCCACGAGCCGGAGCCACAGCGTCTGGTTCACGTCGGACGCGTCCGCGGGGCGCAGCCGGTGCTTGTAGATCACCGACACGACCAGCGGCGTGTACCGGTCCACGATCTCGTTCCACGCACCCTGGTCGCCCTCGGCCGCCGCGCTGACGAGCGCGGCGATCGGGGATGCTGAGGTCACGTCGACTCCTTGCGGTCACGACTTGCGGAGGCCGAGGCTGCTCCCCAGATACAACGCTCCGCCGATTATTTGACGAAGACCCCGTAGCCGGCGTGGAACTCCGGGTTCACCAGCAGTTTGTCACGCGCCTGGACCGCGGTGAGGCCGTCCTTGGCCATCGTGGCGGCGATCCGCCCGGTCACCCACGGCGCCGCGAACGACGTGCCGGACCAGTAGGCCCACAGCGCGAACGGGGTCGCGCCGGGCTCACCGGGGAGCTTCCACTCGCCCTTGAGGTAGGTCGAGGAGCGGTTGCCGATCGCGCAGGCGTCGACCCAGTGGCCGAAGCTCGAGTAGCAGGCCGGGATGATCAACCCGTCGCTGTTCTGGGCGAGCGCGGCGACGGCGGTGACCCGGCAGAACGCGGCGGGCCAGCTCGGGCGCTGGTCACCCCGGTTGCCGGCGGAGGCGACCACGACGGTCTCCGGCGGCAGCGCGTTGATCGCGTTGCGCAGCGGCTCGGAGGCGACGTCGTCCTCGGTGTAGCAACCGAGGGACAGGTTGAGCAGGTCGAGCCTCTTCTTGCCCATCTCGGCGATCTTGGCGACCAGGCGTTCCTCGTCGCCGAAGCCGTTCACGTCCAGAGCGACCTCGGGGTCGAACGCCACACCGCAGGCCGCGCTCTGGATGACGCCCGCGACGAACGTGCCGTGGCCGCCCTGCAGGCCGAAGAGCGCGCCGCTGGTGTAGGCGGGGTCGACGTCGTCGGGCTCCTTGAAGAACCTGTCCTTGAACCAGTCGGGGTGCTCCAGCTGGGCGCCGGAGGAGATGCCGGTGTCGAGGACGCCCACCCGGATGCCGGAGAGCCGGTCGTCGGCCTTGGGAGGGTTGAACGGGTCGGTGGGCCGGGGCCGGTCGCCGGGGTTGCCCATGACGTTGCCGCCGTGGCCGACGACGACGTGGTGCGGTTGCACGAGAGGCACCCGCTCGTTCGGCCAGTTCCGTTGATCCCTCAACAACCGGACGATGCGCGGAATGTCTTCGAGGTTGTTCGGCAGGATCAGCCGGGCCATTCCGCCGAATCCATCGGCGGGGCGCGCCTCGACATTGTTTTCCCGCAGTTTCGCGATCACCCGGTCGAGGTCCGCCTGCGCGACCAGCAACTGACCTGGGCGGTAAAGGAATTCACGCCCGCGCTCGGCGTGGAAGCTGATGTTCTTGTCCTCGGCGATGAGCTGCTGAAAAGCTCTTTCGTAAAGCTCAGAACGTTCCGGCGATTTCGACACCACGGCCTCACAAAGCAGTGTTTGACGGGGGCCCCGACCGAGCTTGATCAAGCTACCACAGCGGATAAAGTGACGCCGTGACCGACTTTTGTGCGGAGGACGCGCTGGCGGCCAGGCAGCGCAACCCGCGCGCGGCCGTTGAGATGGCGCGCGCCGTCCTCCGCGCGACGGAAGACCGGTCGGAATGGGCGATCGCCGAACGCGCGATCGGCCTCGCTCTGCGGGAGCTGCACGACTACAGCGGCTCGATCCGCCACCTCCGCCGCTCGATCCGCATCGCGACGGACGCTTCTTTGCCCCGGTTGTCGGCTTTGGCGCAGATGTCGCTGGCCTGGGTGCTCGCCTACACCGGCCGCCACCGCGCCGCCCTGCGCGCACTGGACGTGGCCATGCCGTCGTTGTCAGGCGCCGACGCGGTGGCTGCTCTTATGCAACGTGGCGTCGTCTTCCACTACCTGACCCGCTACTCCGAAGCGCAGCGCGACTACACGGCCGCCATCGCCGGCGCACGGCGCGTGGACGACAAACTGGTCGAGGCGCGCGCTCACAACAACCGCGGCCTCGTGCGCGCATACGTCGGCAACATGCGCGAGGCCTCAGCCGACTTCGACGTGGCCGCGTCGTTGCTGGGCTCTCTGGGCCAGGAGCTCGGCGTCGCCGACGTGCACTGGAACGCGGGCATCATGGCCACCCGCTCGGGTGACGTCCCGGCCGCCCTGACGTTGTTCGACAAGGCCGACGAGGTCTACCGCCGCCTGGACGTGCCCCGCCCCGCGCTGCTGGTGAACCGCCTGGAGCTCCTGGTCTCCGTGCCGCTGGTCGACGAGGCGCGGGTCGCCGCCGACCGGGCGATCACCGAGCTGAAGGCTCTTCGGAACCCCTTCGCGACCTCCGAGGCGCTGTTCTTCCGCGCCCGCATCGCGTTGCTGGACGACGACCTGGACGCGGCTCATGTGTTCGCCGCCGAGGCCCGCCGTCGCTTCCGCCGCGAGCAACGGCTGCTGTGGGCGGCCGGTGCGCGCTACCTGGAACTGCACGCCGCCGTCCTGCGCGGTGACCGGACGCGTTCTTTGCGGGTGGCGTTGTCGCGGGTGGCCGACGAGCTCGACGCGATGGACTGGCGACTCCCGGCGCTGGAGGCCCGCATCGACGCGGGTCTTGTCGCCGCCGACCTCGGGCATCGTGTGCGGGCGGTGGCGGAGTTCTCCAGGGCCGCTGCTTCGCGCTCGCGTGGCCCGGCCGGTCTGCGCGTGCGCGGCTGGTACGCGGAGGCGTTGCGGCGCAAGCTCTCCGGCGATGTCCGGGGTACTTCTTCCGCTCTGCGCCGCGGTATCGCGCTGCTCGACGAGTACCGGGTGTCGCTGGGCGCCGCCGAGCTGCGCGCGTTGACCGGCGCGCAGGGCCAGGCCTTGGCTGCGGAGGGCCTGCGTTTGGCCGTGGCTTCCGGCAACGCGGCCCGTGTGCTGTCGTGGACGGAGTCCTGGCGCGCCGGCGCGTTGCGGATGAAGTCGGTGTCGCCGCCCGACGATCCTCGTTTGGAGGACGCACTGGCTTCTCTGCGTGCTGTCACCTCGGACGTCGAGTCGGCCGTGCTGGCCGGCAAGCCCGCGGGTGCGTTGCGCGTGCAGCTGGTCCGCGCCGAACAACGCGTCCGCGACCTGACCCGGCAGATGTCGGGCGGGGGAGCGGTGTTCAAGCCGCCCTCGATGGCGTCTTTGGCCGCTGCCCTGGGTTCTGCCGCCTTGATCGAGTTCGTCGAGTACGACGGCTCTCTCCTGGCCGTGGTCCTGGTCGACGGCCGCACCTCTCTGCACTCTCTCGGTGCTCTGGAGGGCGTGGTCCGCGAAATCCGCCTGCTCCGTTTCGCCCTGCACCGCCTCGTGACCCTGCCACCCAACCTGCCGAACCTCTCCGTGGCCCGCTCCTCCGCCGCCCACGCCGCGTCGTTGTTGTCCACGCGGTTGTTGGAGCCTTTGGCGTCACGCATCGATGGCCGCCCGCTGGTGGTGGTGCCGACCGGTGCGCTGAACAGCCTCCCGTGGGCCGTGCTGGGCCGTGAGGTGACCGTGGCGCCGTCAGCGTCCGTCTGGCTGCGTGCTGCTGCCGCGCCTGACGCGTCCGGTGAGGCCGTGCTGGCGGCCGGCCCGCGAATGGCCGCCGCCCCAGAAGAGATCAAGGCCATCTCCGCCCACGTGCCCGGCCGTGTGCTCGTCGACGACGATGCAACCGTTTCGGCCGTGGCATCCGCAATGGACGGTGCCGCCCTCGCCCACATCGCCGCGCACGGCTCGTTCCGCGTCGACAACCCGTTGTTCAGTGCGTTGGAACTGGCTGACGGGCCGTTGACCGTCTATGACATCGAACGGTTGCGTACGCCGCCTACGCGCGTGGTGCTGTCGGCGTGCGACACGGGCCAATCCGCGGTGCGTCCTGGCGATGAGTTGATGGGGTTCACGGCGGCTCTGCTGGGGTTGGGCACGCGGACGTTGATCGCGCCCGTGGTGCCGGTGCCGACCGACGGCACCGCACCGGTGATGGTGGAGCTGCACCGGAAGCTGGCTGCGGGGCTGTCGCCGGCGGAGGCGTTGGCGGAGGTGCAGCGGTCGGCTGCGGACGACGCCTCTTATGCCGCCGCGGTCGGTTTCGTGTGCTTCGGTGCGGGCTGACTCACTCCGCACCCATCGCCTCCAACCACGCCAGCAACGCCCGCACGGTCGGCCGCTGGGACGGGGTGAGCTCGTCCTTGTCGAGGACCTCCCGAACCACCTCGATCGCCTGCTGCCGGTACCCGCACTTCACCAGCTTGTTGGCGGTCTCCACGCCTTCCTTGATCTCGAAAGCGTGGTGGCGCAGCACGTCGAGCCATGTTGCCGCCATGTGCGCGAACAGACCGCGCTGCCGGAATTCGCCAGCCACTGCGAGCCGCCGGTCCATCGACATCGCGTGGTTCGCCACCTGCTCTGCGATGAAGTCAGCTCTCTTCGAACCGGCTATGTCGAGCAGGATCCCGACGCACTCCTCGACGTAGAGGCCGCCGTCGGCCAGTTCGCGGAGCAACGCCTGTTCCGCAACGGTGACGGCTTCCTCGGTACGCCCGTACTCCTGCAGGATCGGTGCCACCAGCCTGGCGTTGTCGGCAGTACCGCTCCCGACCAGCGTCATCAACTTCTCCAGCAGAGGTTTTGCCTGTTCAGGCATTTGCTGGGAGAGAAGCGAGTCCGCGCAGGATGCGAGTGCCGCCGGATCAGGGGCGCGCTGGCCGATCAGCCGTTCGACCAGGTCCTCCCCGAGTTCGTGATGTCCGGCTCTGTAGAGCAGTGGAGCGACTTCGGCCCAGCGTTCTTCGGAGCCGCCGACCGTCACCACGTGCACGTCCCGGCTGAATCCGTCAAGCTCAAGGGCTGACTCGGCGATGTAGGAGAAGTCCCACTCCGTGACCTTGCGTGCCAAGAATTTCCTGAACAGGTCCTTCGCGGAAGGTACGCCCTGCAGCACCAGAGCTGCCAGGGGTGCAGTCAAATCCGCCGAGACGTCGTCCACGCCATCGAGCAGAGCGCTCGTGGACATCGGATCCACCTCTGCGATCAGCACGCAGGCGGTCACCTTGGCGTAGTCGGTCGTGTCCGGATCGACCGCGACGCCTCGGGCCAGCTCTGCCGCTGCGTCTTGATGATCGCCGAACAACGTCGTCGCCGCGGCCAGCTTGTGTTCCGCCGACCTGTCTTGGACCTGCTCGACGATCCGGTCAACCGCTGTTGCGCCACCGTGGGACATCAAGGTCATCACGGCAGCTCGGAGCTCGTGTGATTCGGCGTCCTGTCGCGCGAGGATCATGTCAGCGGCCAGTAGTGCTTCGTCCGTGCACCGTGCATCCGTGGCTAGACGCAGCAGTCGGAACCAGCTGATCAGCTCTTGGTCACCCAGGTTGGAGACCTGCCGCGGGAGGTGCGAACTTCCCGGCGTAGCAGAGGACTCCTGCCGCACGTGCTTCACCATCCGGCGGAGGAGTCGCGCAGCCGGGTCAGGGCGTTTCAAGTCGAGCAGCAGCCGAACATTCGCGACGATGCGCGCGTAATCGGACTTGTCTGCTTCGTCTGTGTCCTGCACAACGAGCTGTTCCGCGCGATTTGCACCGTCCGGCAGGATCTCGGCCAGCCCGAGCGCTACCGCTCGTCGGACAGCCGGATCCGATGATGCGAAGAACTGTTTCTCCAGCCACTGCATCATGCCGGCACCGGCTTCGAGTTGCTCCAGCGCGACCGCGCAACAGATGCGGATCGTCAGGAGCAGTTCGGGGTTCTGCTGCAGTTCGCGCAACCGGGCCGTCAGTCCGTCCGCGATCACCGTGCTGGTCAGACCACGCACCGCTCGGCAGACGTCGTTCACCTCGCTCCAAGGGTCGCTGCCGGGATTGATGGTCAGTATGAGGTCGACGAGCCGGTCCACCAGGTGTGCGGCCTGCTCCGCAGGCACATCTACGTTCTCTGCGAACAGCTTGGCCCCGAGCAGCACATGCTTGCGGCCCCGGTTCAGCAGGCGTTCGACGACCAGACCGATGTCGTTGCCTTCAACACGGCTCCACAGCACGAAGGTGAAGAGCACGAACGTCTCTTTGGCCTCGTTGGTGCCGCGCTCAACCCACATGTCGAGCTGCGGGAAGTCGGCGGGGATCCGCGGCGCCTCTGCACGCGCCGCCAGGTATTCGGCGAACAACCGGTGCAGGAAGTCGATTCCCTCACCTGTCTGCGCGAACACGCCGATGCTCGTCAGCACGGCCTCCAGGTCCTCCGGCGGACTGGGATGCTTGATCCACTCGGTGGCGATCTCCGCCAGTGGGAGCTCCGAGTCCAGCCGTTCGACCGCGAGGTGTTCGATCAGCTCGGCTCGATTGGCGTAGATCCACTCCACGAGCTCCAGCCGCTCGGGGTCGTCGATCGTCCGGCGGAGCTCCGTGATCGTGGTGCGCTGGTTGAGCTTCTCGTCCAGCAGGTAGGTCAGGAACCGCTCACACAGGTCCACGCGGTTCTGCGGGAGCTCGCGTTCCGGCTCCAGGGTGTTCGCGATGGCGGCGATCGTCGCGAACAGCGGCACGGTCACCAGTTCGCGCAGTCGGCCGTCCATCACCTGCCGCAGGAACTCGCGCTTCCGCTCCGCCACGCGCGTCGGGTCCTGGATCTGGAACCACGCCTGCGCGAACTGCTCGAGCTGGTCCACGCCGAAGGGTTCGATCCGGTAGCGGTCGAGGTGGGCGACCTGCAACTGGTCGAGCACGCCGGAAGCGAGGTCACGTGAGGTGATGACCAGCTGGTGCTCGGAGCCGTGCCGAATGCGGCTGGTGAGCGCGTCGATGACCTGGCGCAGGTGGTCCGGCTCCACGATCTCGTCCAGGCCGTCCACGAACACGAGCCAGCGGGCGCCGAGGGCGGGGCGGGCGAAGAGTTCCGGGCGGGGTGGGGCGTTGAGCTTGTTGCTGCGGACGGCCTTCGCCAGCAGCTCGCTCCACGACTCCTCGCCGATCAGGGCTTTCGCGCTGACCCGCAGCGGCATCAGCGGCTCGGCGAGAGGTGGGTTGCCGCTGGGCTCGAGCCACTCGTCGGCCAGGACCTGGACGTACATGTGGCCGAGCGTCGACTTGCCGGAGCCGGGGCCGCCGGTGATCAGCAGGTGGCGGCCGGTGGCGAGTGCCTCCCTGAGCGACATGACGCTGTCGCTGTGCTTCGGTTCGCGGTCGACGGCCTTGGAGTCGCCCTGTTCAGGGTCGGGCTCGGGTTCCTCGTGGCGTTGCGGGAGAACCGAGCGTTGCACGTAGACGTCGATCAGGCGGGGTTGCTTCTTCAGCAGCTGGAGGTGGTGGGGGAGCGTGACGGCGGTGTCGCGCTGGACCTTGAGCAGCTCCTCCAGCTCCCTGGTCAGCTCCGGCCGGTCGCGCCACGAGGTCAGCGGCGGGTACTCGGGCTCGACCGCACCCACGTTCACGGCGCCGTAGATGTCGCGGCTCTGGAAGACGACGCCGTGGACGGGGCTGTTGACCTCGTTGTGCATGCAGAGGTTCTACCCGGCAGCAGGACAGGGGAACTGGTCAAAACAAGGTCAGTTCAGAGTCTTATGAAACGTCTGAGTCTCGCTTATCGTTGCTCGCCATGACAACGAGGTCGTGGTGGGGCTGGGGCAACGTCGAACACGCCGTCACCCCGGAAGAACGGCAGAAGCTCGTCGACCGCGTCCGCGCAGTCCTCCCGAACGCGGACCTGACGCTCCACGACCCGCCCGACCCCGAGACGCTGACCATTCCGAAGTCACGCATCCAGCCTTCGCCCCTGTACTCCACCGACCCCCTCGACCGCCTCACCCACGCCCGCGGTCAGGCCTACCGCGACGTCGTCCGCAACCTGGCCGGCGACATCGGCACCGTCCCGGACGCCGTCGCGAGGCCGCGGACCGAGCAGGACGTGGTCGACGTGCTGGACCACTGCGGCAGCAACGGCATCGCGGTCATCCCGTTCGGCGGCGGCACCTCCGTGGTCGGCGGGGTCGAGCCGCGTGACATCGACGGACCCGTCGTGACGCTCGACCTCGGCCACCTCGACCGCGTCCTGGAGGTCGACCCCACCAGCAGGGCCGCGCGGATCCAGGCCGGCGTGCTCGGGCCTGACCTCGAAGCGCAGCTCAAGCCGCACGGGTTCACGCTCCGGCACTTCCCGCAGTCCTTCGAGTTCTCGACGCTGGGCGGGTGGCTCGCGACGCGCGCAGGTGGGCACTACGCGACGGCGACCACGCACATCGATGACTTCACCGAGTCGCTCAGGGTGGTGACACCCGTCGGGGTCAGCGAGTCGCGGAGGGTGCCGGGCAGTGGGGCCGGGCCGTCGCCGGACCGGATGTTCCTGGGGTCTGAAGGTGCGCTCGGGGTGATCACCGAGGCGTGGATGCGGGTGCAGGAACCGCCGCGGCACCGGGCCGGAGCGTCCGTGCGGTTCGCGGACTGGGGGCGGGCGGTCGAGGCGGTGCGGGCGATCGCGCAGTCCGGGCTGCACCCCGCGAACTGCCGGTTGCTCGACCCGGCGGAGGCGTTCCTCAACGCCGGGTCGAGCCAGTCCGTCCTGGTGCTGGCGTTCGAGTCGGCCGACCACCCCGTGGACGCGCACCTGCGGCGCGCTCTCGAACTCTGCGCGGGTGGCGAGGTCGTGGAGGGCACGGCGGCGAGGTGGCGCGGCTCGTTCCTGCGCATGCCCTACCAGCGCGACGCGATGGCGCAGCACGCGATGATCACCGAGACGTTCGAGACGGCCTGCACGTGGGACCGGTTCGCCGAGCTGCACGCGGCCGTCACGGAAGCGGCGACCAGCGTGCTCGAGGAGGTGTGCGGGGCCGGGATCGTGACGTGCCGCTTCACCCACGTCTACCCCGACGGGCCCGCGCCCTACTACGGCGTCTACGCGCCCGGTCGGTGGGGCAGCCTGCGGCAGCAGTGGGACGAGATCAAGGTCGCGGTGTCCGAGGCCCTGACCGGCGCGGGCGGCACGATCACCCACCACCACGCCGTCGGCCGCGACCACATGCCGTGGTACCTGCGTCAGCGCCCGGACGTGTTCGGGACGGCCCTGACCGCGGCCAAAGCCGCCCTCGACCCGGCCGGAGTGCTCAACCCCGGTGTCCTCACGACACGATCGACCGCAGGACCAGCGCCGCGATGAACACCACCGTGAACGCCAGGTCCAGCCCGAACCCGCCGAACCGCACCGGCGGCAGCACCTTGCGCACCGGCGACAACACCGGTTCGGTCACCGCGTACGTCACCCGCTGCACCTTGGGCACCCAGGAGCCGCGCGCCTGCAGCGCCACCGCCCAGTCCACGATCATCCTGGCGATCATCACCAGGATGAACAGCGTCAGCAGCCAGCCGAGCACGAAGCCGATCACCGTGGCCTCCTCATGTGTCCAGTACGTCCATCAAGCCACACGAAACTGAGAGGCGCCTGGCAACTCGCTGGGACAAGATTCAGCCTGTGGCGTACGACGAGGGCCTGGCGCACCGGCTGGGCGACGCTCTGGCGGCGTTGCCGGGCATCGGCACGAAGAAGGCCCTGGACCGGCTCCGTGCCGCGCTCGACGGCTACGGACCGCTGCGCGAGGTGACGGAGCCGGGCGGGCTGGGGTTCGAGTGGGACGGTGACCTGCTGGCCCGCGTGGTCGGCGACGAGGTCCTCGTGCGGTCGGTCGCGGGCTGGACGGTGGCGACCGGGGACTTGCGGGCCGCCGTGAACGGCGCCGCTCGGGTCGTGCTGGACGAGTGCGTGGCGCGCTGGCACGAGCAACTCGCCTCCGCGGATCCCGCCGGGTCCACCCGCGCCATGCTCGCCCTCACCCACCACGAGCCGGATCGCGCCGCGCTGCAACGCCTCCTGCTCGACCACGTCCGCCATCCCGACCGGAACCTCCGCCAGCTCGCCGTCACCTGCCTCGGCCACGTGGGCAGGCTGGACCGGCAGGTGCTGCCCGAGGTCGTCGAGCGCCTGAACGCGTTGCTCGACGACCCCGAGCTCGGCGGCACCGCGGACGACGCGCTGGGCGACATCGAGTCCTTCCGCCGCTGAGCCTCAGAACCGCACCAGCGGCCCTCCCGTGACGAGCTCGAACACGAAGTTCACGAAGAAGAACCCGAAGAACACCACGTTCAGCACCAGAACCACGTGGTGCCACCACCGCGGCCGCGCCGGTCGAGGTAGCCGGGAGTTCAGGTACATCAACGCGAACGGGAACATCAGCGCGCCCAGGTTCGACATGTTCGCCGAGATCTGCACCAGCTCCACGGGCAGCGCGAGATGCATGGCACCCGCGATCAGCACCAGCACGAACAGCATGAACGGGTAGTAGAACCGGCGCGGGTCGTCCTCGATGCGACGACGCAGCTTCGGGGACACCGCGTGCATCGCGTCGGTGAAGTTGCGGACCAGCGCCTCGAAGATGCCGAGCTGGGTGGAGAACAGCACCAGCACGCCGACCACCAGCATCAGGTAGAACATGCCCTGCCCGTACAGCAGGCCGAGCTGCTCGGCGGAGAACGTCGGCACGTTCGCCGCCGTCGGTTGCGTTCCCGACACCGCCACGAGGTGGGCCATCAGCACGGTGGGCAGCAGCATGCCGAGCATCGCGCCGACGAAGAACACCGCCCACTGGTCGATCAGCAGCAGCCGGTACCAGCGCCGCCACAGCGAGGCGTTGGCCGGGGTGTCCACAAAGGTCACCCCGACCGGGCGCAGCTCCTGCTTGCCGCCGCGCAGGCCCGAGATGAAGCCGACCCGGTGGCCCATGCCGTAGCCCTTGTCGCGGTAGTGGTTCATCGCGTACCAGTTCAGGCCCGACGCCAGGGCGGTGAAACCGGCGAGGCCGCCGAGCTGGGACGCGGTGATGCCCTCCGGTGGTGCGGCGGGGGTGACGAGGCCGCGCACGCCCTCCGACCAGACCGAGAACGGCACGATCGCGACCGTCACCACGACCAGGACCAGCAGCAGGGAGCCGACGAGCACCCAGTTCGTGAGTTCCAGGGCGCGGGAGACCTTGCGGGCGCCGGCGGTGATCAGGAAGACCACGAACAGCAGGCCGATCGCGAGCAGCCGCACGTACTCGATCTCGTCGGGGCGGTAGCCGCGGCCCGCGATCAGGGCGAAGAGCCCCTGCCCGGCGCCCGCCGCCCAGCCGCCGAACAGGAACGCGAAGTAGAAGACCAGCAGCGACACCGGCACCCAGAACTTCCAGCCCGGTGGCACCCGGCCCCAGCCGACGACCGGCACCTCGCCGGTCGCCACGACGTAGCGCGCGATCTCCACGTTGTAGAACGTCTGCAGCAACGCGGACACGGTGATCACCCAGCCCACGCCGACGAAGCCGAACTTGCCGACCGCCTGCGGGCCGAGCAGCCACTCGCCGCTGCCGATGGAGATGCCGAGCGCGATCAGGCTGGGGCCGATGACGAACTGGACGATCTGCCGCGGACCCAGCTTGCGGACCTTGAAGACCTCCTCCGGGGCCGGCAGGTCGTCCAGGTCCAGCGGTGGCCTGCTCACACCGATTTGCGTCGACGCCATTGTCGCAACCTCCCGAGACACGTCGGGGCAGTAGGTCCCAACTTTCGGACGTGCCGGGCCACCGGTCAACTACGTAGCGTGCCTCCTCGGATTCCGAGAGGGGACACGGACGTGCGAAGAACACTGGCGGGAGCAGCGGCGCTCGCGTTGATGACGGCGGGCTTGGCCATCCCGGCCGCCGCGACGCCGGCCGAGCAGCCCGAAACGCAGGTGCGGCAGCAGAGCGACGAGCAGCCGCACGAGCTGGAGCTCAAGCGGCGCGCGCTCAAGCAGCAGGCGCTGGCCGAGGTGCTGACCGGTGAGGTGACCGCGGAGAAGCGCGGCACCAGCACCGTCGCCAAGGTCGGCAAGAAGCAGGCGAGGGACCAGTACGTCGAGCTCAAGCGGGAGAAGACCGACAAGATCTTCGTGATCCTGGCGGAGTTCGGCAACGAGCGGCACCCCGACTACCCCGACCGCGACACCGACCCGAACACGCCGGGCCCGCTGCGGTTCGACGGGCCGGTGCGCAACCAGATCCCCGCGCCGGACCGGGCCGTGGACAACACCACGATCTGGCGGCCCGACTTCAGCCGGCAGTACTTCCAGGACCTGTACTTCTCGCGGGCGAAGGACGCCAACTCGGTCGCGAACTTCTACGACAAGCAGTCCTCCGGGCGCTACACGGTCGACGGGCTCGTCACGGACTGGGTGAAGGTCCGCTACAACGAGGCCCGCTACGGCCGCAGCAACGGCTACCCGTGCGGCGACAACATCTGCAACAACTCCCGCGAGCTCATCAAGGACGCCGTCACCCAGTGGGTCGACGACCAGCGTGCCGCGGGCAAGACGACCGAGCAGATCACCGCGGCCCTGCGCGAGTACGACGTCTGGGACCGCTACGACTACGACTTCGACGGCGACTTCAACGAGCCCGACGGCTACATCGACCACTTCCAGATCGTGCACGCCGGTGGTGACCAGGCCGACGGCGATCCGTGGCAGGGCGAGGACGCGCTCTGGAGCCACCGCGGCTACGCCTTCAAGAACTACAACACCGGTCCCGGCACCAACAAGCTCGGCGGCGCGCCCATCGGCGACACGGGCCTGTGGGTCGGCGACTACACCGTGCAGCCCGAGAACGGCGGCGTCGGCGTGTTCGCGCACGAGTTCGGCCACGACCTCGGCCTGCCGGACCACTACGACACCAACGGCGGCACGAACGGCGTCAACTGGTGGTCGATCATGGGCCAGAACCGGGTGAACGCGCCCGGTGAGGCGACCGGCGAGCGCGCCAACGAGTTCTCCGCGTGGGACAAGCTGCAGCTCGGCTGGCTCGACTACGAGATCGCGGTCGCGGGCCAGGAGCGGACGTTCCAGCTCGGGCCGCACGAGTACAACACCGCGAAGGCGCAGGGCCTCGTGGTCGTGCTGCCGGACATCTCCAAGTCGTTCGACTACGGCGCCCCGTTCGCGGGCGGCAAGATGTGGTGGAGCGAGAAGGGCAACGACCTCGACCACTCGATGACCGCGCCGCTCGACCTGCGCGGCAAGACCACGGCGTCGCTGTCGCTCAAGGCGCGCTACGACATCGAGGCCGACTACGACTACCTCTACGTCGAGGCGTCCAACGAGGACGGCAGCTGGACCCAGCTCGACGGCACCGCGAACGGCGCGCCGTTCGTGCGCGACTCCGGCGACGCGCCGGCGATCAGCGGTTCGTCCGGCGGCCAGTGGGTCGACGTCACGGTGCCGCTGGACGCCTACGCGGGCAAGAACACCAAGCTGCGCCTGGCCTACCGCACCGACGGAGCGCTGGCGCCGCAGGGCTTCTTCGCCGACGAGATCACGGTCGTCGCGGACGGCACCCCGGTGCTGACCGACGGCGGTGAGACGGCCGGGACGTGGACCACGCGCGGTTTCCGCACCACGGAAGGTAAGGAGACCAAGGCGTTCGACCAGTTCTACATCGCGTCGAACCGCACCTACGAGTCCTACGGCCAGTACAACCGCACCGGCCCGTACCGGTACAGCTTCCAGGACAAGCCCGACCTCGTGGAGCACTTCCCGTACCAGGACGGCCTGCTCGTCTCGCTGTGGAACACGTCCTACCTCGACAACAACGTGAGCGAGCACCCCGGTGAGGGCCTGATCCTGCCGATCGACGCCAACCCCGCACCGCTCTACAACCTCGAGGGCCAGCGCTGGTCGCCCACCATCGGCGGTTACGACGCGCCGTTCTCGCTGCAGAAGTCGGACTCCTTCACGCTGCACGTCAACGGCAAGGCGTCCTACGTCCGCGGCGCGGCGGCACAGCCGGTGTTCGACGACACGAAGCAGTACTGGTTCGCCGAGCAGCCCAACGCCGGCGTCAAGCTGCCCGCGGTCGGCGTCGGCCTGCGGGTGACCAAGCAGTCCGGCACGTCGATGACGGTGAAACTGTTCAAGACGAAGTAGCTTGAGCGGTATGACCGCTGCTTCCGACATGCTGGCCGTCGCCGTCGAAGAGGCGCGCACGGGACTCGCCGAGGGCGGGATCCCGATCGGCGCCGCGCTCTTCGACGGCGACGGCCGTCTGCTCGGCCGGGGCCACAACCGCCGCGTCCAGGACGGCGACGCCTCGATGCACGCCGAGACCTCCGCCTTCCGCGACGCCGGTCGTCAGCGCGGCTATCGCGGCACGACGATGGTCACCACGCTGTCGCCGTGCTGGTACTGCAGCGGGCTGGTGCGGCAGTTCGGGATCTCGAACGTGCTGATCGGGGAGGCGACGACGTTCCACGGCGGGCACGACTGGCTGGCGGAGCACGGCGTCGGGATCACGGTGGTGGAGGACCCGGCCTGCATCGAGATGATGACGAGGTTCATCGCCGAGCAGCCGGAGCTGTGGTTCGAGGACATCGGCCAGGATTGACCTGGAGCGCGCTCCAGGACCTAACCTCGCCGCCTGTGGACGTACTGGTGACCGGTGGGAACAAAGGGCTCGGCCTGGAGACGGTGCGGCAGCTGGCCACGGCCGGCCACACCGTGTGGCTCGGCAGCAGGGACCTGGAGCGCGGCCGGGTGGCCGCCGCCGAGGTGGGGGCGCGTGCCGTCCAGCTCGACGTGACGTCCGACGAGTCGGTGGCGGCGGCTGTCCGGATGGTCGGGTCGCTCGACGTGCTGGTGAACAACGCGGGAGTGTCGCCGGAACGGGGCCCCGGGTGGTTCGTCGAGACCGCGGACCTCACCGCCGAGGTGCTGCGGGAGACCTTCGAGACCAACGTGGCCGGGACCGTCCGGGTGCTGCACGCGTTCCTGCCGCTGCTCGAACGGTCCGAGGCCCCGGTGGTCGTCAACGTCAGCAGCCGCCTCGGGTCGTTGAGCACGGTGGCGGCACCGGGCAGCCCGCAGCACGACTACCCCGGTGCCGCGTACCCGGCGTCCAAGGCCGCGCTGAACATGCTGACCATCCAGTACGCGAAGGCCTTCCCGCGAATGCGGATCAACGCGGTGGATCCGGGGTTCACGGCGACCGACCTCAACGACCGGACCGGGACGCAGAGCGCCGCCGAGGGTGCCGCGATCATCGTGCGGATGGCGCAGGTCGGGCCGGACGGTCCCACCGGCGGGTACTTCGACGGCTCCGGCCCGCTGCCGTGGTGACCGCGCGCTCAGGCCGAGTAGCGGTCGACCGCCTCGTCCACCGACCCCAGGATCGTGAACACGGTGTCGAGCCCCGTCGCCTCGATCGGTCGCAGTGCCGCCCGCGACGAGGCGACCAGCACGAACTCGACGTTGTTGCGGCCGGCGCGTTGCTGGCCGAGTACCAGGGCCTCCAGGCCGGCGGAACCGAGGAAGCGCACGCCGCCGAGGTCCACGACGACTGCCCTGTTCGCCTCCACCACGTGGGTGTCGAGGGGTGCGGTGAGCTCGCTCGAGCTGGTGGTGTCGAGCTCACCGGACACGTGCAGCACGACGACGTCGGATGAGATCCGGTCGACGACCACGGTGGCCAGTGTGGTGGGGTCGGGCACGCTTGCTCCTTTCGCGGCGGTCAGCATCCCACGTTAACGCGGGCGTGCGGGAGCAGCCAGCGGCCCCTCAGCGAAGAGCGGCCCGACTCACAGGCGGCGTGGACGTGCTGGACGAGGCGCGCGTGCAGTTCGTGGCAGGCGGTGAAGCCCAGGCGGACGTCGTCCGGCGGGCACTGGACGGGCAGGAGCTGGGCGAACGGGTCACCGCCGATCGTGTCGACGGCGGTCAGGAAACCGACCAGGGCGCCGACGAGGCGCTGGTGCAGGCCGAAGAGGCTCAGCGCGTTGGCCAGCGCCAGGGTGGGGGCCGGCATCTCGTCGACACCCGTGCCGCAGTCGAGGTCGCGCAGCGTCACGGTGAACAGGACCGAGTGCGTGCGTTCGTCGCGGGAACCGTAGGCGTCGCCGTGGATGTCGCGCAGGGCCGAGCGCATCTCCCGGCGCGGGTGCCAGAACGCGTGGTGCTTGCGCAGCTCGGCCGCACCCGTCCCGTCGAGCACCACCGCCGGCGTCGTCTCCCGCAGCGAGCGCAGTCCCCGCTCCCACCGTGCTTCCAGGGCGCTCAGGAACTGGGCCAGCGCCGGGTGGTCGTCCCAGGCCGGGTGCGCGTCGTCGAAGCCGCGGGTGCGCAGCCGGTAGCAGGTCCACAGCGAGATCTGGAGGTCGTCGTCGAGACCGGGCTCCCTGGTGCCGCCGCTGACGAGCAACGCCGGGCGCGGCACCGGCGCCGAGCGGAGTGCGGCGACCAGCGCGGCGCTCATGTGGCCGCGGGGAGCAGGGAGGCGCATCAGGTTTCCTCACGCGTTCGGGCGATCAGCATGTCCACAAGGGACTCGGGGTCCTGGCAGCGGCGCTGGCGGGCGGCACCGCAGCCGTTGTGGCGCAACCAGTCGATCTGCCGCTCCACAGTAGACAGCGTGCCGCGTTCGCGCAGCGCGGGCGCGACGTGCTCGACCAGTGCCACCGCCCGGTCGAACGCCGGCAGGAGCTTCCCGGTGGACGGATCGGCGGCCAGGCCGTCGATCCCGTCGCGCGACGCACGCCAATATGCCGCTCGCAGCACGGAGTCGTCCACCCGCTGTTCGGGGGGTTCGGAGGCGACGAGTGCCCTGACGAGCTCCGCTAGCACGACGACTTCCGTTGCCAGCAGCGGGATGTCGGCGACCCGGACCTCAACGGTCGGATGATCGGCGGACGGGCGGACGTCCCAGTAGACCATCGCCCTGTCGATCAACGCCTCGGTGGCGATGAGCGCCTCCACGGTCCGGTCGTAGTGCTCGGGACCGTCCCACCGCGGCGGCGGCCCGCTGACCGGCCAGCGCGACCACACCATCGACCGCCAGCTCGCGTACCCGGTCTCCTCACCGTCCTGGTACGGCGAGTTCGCGCTCAGCGCGAGCAGCGTCGGCAGCCAGGCCCGCAGCTTGTTCGACGCCTCCAGCGCCGCCGCCTTCGAGGGAACCCCGACGTGCACGTGCAGCCCGCACGCGCCCTGCCCGATCACCAGCCGCCGGTGCGAGTGCTCGATCCGGTGATACCGGGGGTCGTCCGATCCGGGGGGCGGCCCGGCCTTCCCGATCGGCGGCATGCCCGTGGCCACCAGCCGGCACCCGGCCTCGTCCGCGGCCTCCACCAGCACCCGGCGAGCCGCGCGGACCTGCGCGTCGAGCTCGGCGGAGGTGTGGCACACGCCGGTGGCGACCTCGATCTGGAACGGCGTCAGCTCGCCCTGCACGTCGAGGTCGCCGGGGGCGCGGGAGAGCTCCCCGACCCTCGGTGCCAGGGCTACCGGTCGCCGTGACCTCGGGTCGACGAGGAGGAACTCCTGTTCCACACCGACCGTGTAGTCATCTTTCATCGGCGAGCGGGTACCCGGCTCCCATGCTGATCAACCACGAGGTGTCCAGTTGAGACTCCGGCGCAGCAACACCGCAGGTCCCGGCTGGACCAGGCGCCGGCACGGGAAGGGTTTCCGGTACGCGACCACCGCCGGCGAGCCCCTCGGGCCGGAGGAGGTCGCGCGGGTGAAGGCCCTGGTCATCCCGCCCGCGTGGCGGGACGTGTGGATCAGCCCGCACCCGAACGGGCACATCCAGGCCATCGGGGTGGACGACGCCGGCCGCCGCCAGTACCTCTACCACGAGCAGTGGCGGATGAACCGGGACGCGGAGAAGTTCGACCGCGTCCTGCTGCTGGCCCCGAGGTTGCCGAAGTTCCGCGCCCAGATCGTCGCCGACATGAGGACGCGGGGTCGCCTGCGGCTGCTCGCCATCGCGCTGCGCATGCTCGACCTCGGCGTCTTCCGGGTCGGTCACGAGGAGTACGCGGAGGAGAACGGCAGCCACGGCGTCGCCACCCTGCTGTGCGAGCACCTGCAGGTGCGCGGCGACCGGGTCAGGTTCCAGTTCCCGGCCAAGCACGGCGTCCAGGTCGACGAGGAGATCACCGACCCGCAGCTGGCCCGTGCCGTCCGCACGCTGCTCAAGGACCGGACGCCGGACTGCCGCGTGTTCGACATGACCGCCTACGACGTGAACGAACGGTTCCGCGAGCTGGTCGGCGACCAGTTCACGGTCAAGGACCTGCGGACCTGGCACGCCACGGTCGCGGCGGCGAAGGCGTTCGCCGAGGTGCTGCGCGAGCGCGGCAAGCCCACGAAGCGGGCGGTCAGCGCGGTGATGAAGGACGTGGCCGAGCACCTGGGCAACACCCCGGCCGTGGCGCGCAAGTCCTACGTGGACCCGCGGCTGGTCGAGGCGTTCGAGAACGGGAAGGTGATCGGCGGGGGAGACCCGGAACGGGCGGTGCTGCGGCTGCTCAGGGTGTCCTGAGCACCTGGGCCCGGTCGCACTGGCGGCACCAGACGGCGCCCTGCGCCGCCGCCAGTGCGGCGAAGCCGGCGAGGAAGTGCAGCGCGTTGCTGCCGAAGTTGACGTTGAGCACGTTCACGACCTGCTCGTCGTAGCGCGCCATCCCCAGCCCGAACGTGACCAGCAGGGCCGCGGCCACCAGCAGCGCGGTGTTGCCCAGCGCCTTGAGGTTGCGGAAGGACAGCAGCAGGGCGGCCCCGAACACGAGGTGCAGCACGTTCTGCAGCGGGTTGACCCGCAGGCCGAGCAGCCAGGTGTCGGCCTCGGCGGCGAACCCCGAGAAGCCGGTCACGAGGAAACCGGCCACTCCCCAGAGCGCGAGCAGCGCGCCGGTGCCGATCGCCAGCTTCTGGGGCCACCGCAGCCGCTTCATCCCGTCAGTATCACCAAGGCCGGTCATCCGCGCTCGCCCATCTCACTCGTCTGCCAACAGGTCGTTGCGCAGCTGGTCCAGTGACTTGGTCAGCAGGCGCGAGACGTGCATCTGGGAGATCCCGACGCGGCGGGCGATCTCCGTCTGGGTGAGGCGGCCGAAGAACCGCAGCACCACGATCGTGCGTTCCCGACGGGGGAGGCCCCGCAGCATGGGCTGCAGGGCCTCGTGGATCTCGACGCCTTCTAGAGCCGGGTCGTCGACCGTGTTCTCCTCCAACGCCTCCAGCGGGGCGAACGCGACGTTCTTCTCGACGCGCAGGCCCTCGTAGACGTCGGCGAGCCCGATGCCCAGGTGCCTCGCGATCTCGGAGGGAGTGGGAGACCGCCCGGAGCGGTGCGACAGTTCGGCGGTGGCTCCGTCGATGGCGTCGCACAGCTCCTTGAGGCGCCTGGGCACGCGCACGGCCCAGCACTGGTCGCGGAAGTGGCGGCGGACCTCACCGGTGATCGTGGGCACGGCGTAGGACAGGAAGTCCGTCTGCCGGTCCACGTCGAACCGGTCGATCGCGTTGATCAGCCCGACCGCCGCCACCTGGGCGAGGTCCTCCATCGGCTCGCCGCGCTCGCTGAAGCGGCGGGCGATGTGCCTGGCGAGCGGGAGGTACTCGCGCACCAACCGGTCTCGCAACGCGTAGTAACGCGGCGAGTCACGTGCGGTGCGGGCGAGGTCCTCGAACGCCGCGTGCTGATCTGGCGTCAACGCGCACCACGATCAGACCTGGGGCGGCGGCGTCACGTCGCCCCGCCAAGCTCCGGTCTCGACACCGCGGTTCTCGATGAACTCCTTGAACCGCTTCAGGTCACCCTCGACCCGCTGGCCGACGACGCCCAGCGCCGCACCGGCCTTCTCGATGAAGGTCTCGGGATCGTACTCCATCTGGACGTGCACCCGAGTGGTCTCGTTGTCGATCCGGTGGAACGTCACCACACCGGCCTGCGGCGTGCCCTCGACGGCGGTCCACGCGACGCGCTCGTCGGGGTGCTGCTCGGTGATCTCCGCGTCGAACTCGCGGACGACCCCGCCGATCTTGGTGGTCCAGTGGGTCCTGGTGGGGGTGATCTGGTCGATCTTCTCCACGCCGTCCATGAACGCCGGGAAGGATTCGAACTGGGTCCACTGGTTGTACGCCGTGCTCACGGGCACGTGGACGTCCACCGACTTCTCAATGGTGGTGGTCACGAAACCTCCTCCTCAACATCATCATTTGCCGTCGAACAGTGGTTACCCACCGAATCCGGACCTACACATCCAGATAAGTCCACAATGGATGGTCACGCGGTGTGATGGACCAATCGCGATCTGCGCATCACGGTTCGCCCACAGTGCGCTCAGCGTCTGTGATCCAAGTCATACCAGCGGCATACTGCTCGGTATGTCAGGAGCCCTGGGAGGCGCTGGTGCTCGAGGCGAACAACCTTGAGGTTGTCTACGACGACGTGATGCTGGTGCTCCGCGGCGTGAGTCTCAGGGTGCCCAAGAACCAGATCGTGGCGCTGCTCGGAGCCAACGGAGCTGGGAAAACGACCCTGATGAGGGCGTTCAGCGGCCTGTTGGACGTGCACGACGGCAAGATCACCAAGGGCACGATCACGCTCGACGGTGAACCGATCCACAAGCTCTCCCCGGCGAGGATCGCCGAGCGGGGCGTCAAGCAGGCACTCGAAGGCCGCAGGATCCTCGCCGAGCTCACCGTCGAGGAGAACCTGAAGGTGGGCGGCCACGCCCGCCCCAAAAGGCTGAAGTCCAACCTCGACCGCTGCTACGAGCTGTTCCCGCGGCTGCTGGAGCGGCGAAGACAGAGCGCCGGGTACCTGTCGGGCGGTGAGCAGCAGATGCTCTCCATCGGCAGGGCGCTGATGTCGGAACCGGAGTACCTGCTGCTCGACGAGCCGAGCCTCGGTCTCGCGCCGCTGCTCGTGCAGCAGATCCGCGACCTCGTCGTGAAGATCAAGGAACAGGGCACCACGGTTCTGCTGGTCGAGCAGAACGCCAGCATGGCGCTGTCCATCGCCGACCACGGCTACGTGCTGGAGACCGGCAAGGTCGTGATGGACAAGCCCGCTCAGGCCCTGCTCGCCGACGACGACATCCGCGAGTTCTACCTGGGCCTGGGCACCTCCTCGTTCCGTGCGGTGAAGCACTACAAGAGGAGGAAGCGATGGCTGTCCTGAGCGTCGCCGACATCCGGCTCGCCTTCGACGGGGTCGTGGCCGTCGACGGGGTCTCGTTCGAGGTCGGTGAGGGCGAGCTGTTCGCCGTCATCGGCCCGAACGGCGCGGGCAAGACCTCCATCTTCAACGTGCTGAGCGGCGTCTACCGGCCGCAGCGGGGCACCGTGCGGTTCCACGACCAGGACCTCGTCGGCATGCGGCCGCACCGCATCGCCGCACTCGGCATGGCCCGCACGTTCCAGAACATCGAGCTGTTCTCGCACCTCACCGTCGTCGACAACCTCATGCTCGGCCGGCACAACCACATGCGCTACGGCGCGCTGTCCGCGTTCCTGTGGCTCGGCAGGGCCCGGCGCGAGGAGCTGGAGAACCGGGCTGCCGTCGAGGGCGTCATCGACTTCCTGGAGCTGGAGCAGTGGCGCCGGTTGCCGGTCGGCCTGCTGCCCTACGGCGTGCAGAAGCGCGTCGAGCTGGGCCGCGCGCTCGCGATGGAACCGAAGCTGCTGCTGCTCGACGAGCCGGTCGCCGGCATGAACGTCGAGGAGACCGAGGACATGGCCAGGTTCATCCTCGACGTCCGGGAGGAGCTGAACATCGCGATGATCATGGTCGAGCACGACATGGGCCTGGTGATGGACCTCGCCGACCGGGTGATGGTGATGGACTTCGGCCGCCCGATCCGCACCGGCACCCCCGCCGAGGTGCAGTCCGACCCCGACGTCATCCGCGCCTACCTGGGCGAGCAGCACCGGAGCGTGACGCCATGACGACAGCGACCTCCGCGACGACCACGACCACGGTGGTGACCCGCGTCCGCGACCGGGCCGAGCGCACACCGGAGAAGATCGCGTTGCGCGCCAAGGACCTCGGCATCTGGCAGGAGGTCTCCTGGGCCGGCTACTGGGCGAACGTCGAACTGGTCGGCCACGCGCTGCTCGCACTCGGCCTGCGGCCGGGTGACCGCGTGGCGATCCACTCGGAGAACCGGCGCGAGTGGCTCTACGCCGACCTCGGCACCGTCGCCGCCCGCGGCGTCACGGTCGGGCTGTACCCGACGAACCCGGCCTCCGAGGTCGCCTACCTGCTGTCGCACTCCGGCGCGCGGATCCTGATCGCCGAGGACCAGGAACAGGTCGACAAGGCTTTGCTGGTGCTGGAGGACACGCCGGACCTGGAGTGGATCGTCTACCTGGAGCCGCGCGGGATCCGCGGCCGTTACGACAACCCCAAGCTGCTGGCCTGGGAGGACTTCCTGGCACTCGGTGCGGCGCACCGCGACGAGTTCGGCGGCGAGCTCGCCGAGCGGATGGCGGCCACCGGGCCCGACGACGTCATGACGTTGATCTACACCTCCGGCACGACCGGGCCGCCCAAGGGCGCGATGCTGACCGTGGCGAACGTCGAGTTCGCCGTCCACGTGCTGGTGGAGGGCGGCGGTTTCACCTCGCCACCGCCGTCCTCCGCCGACGTCACGCTGTCGTACCTGCCGTTGTGCCACGTCGCCGAACGCATCTTCACCACGTGGTTCAGCGCGGCCTCCGGCGTGCAGGTGCACTTCGCCGAGTCGATCGAGACCGTGCAGGCGAACCTGCGCGAGGTGCAGCCGACGATCCTGTTCGGCGTGCCGCGGATCTGGGAGAAGGTGCTGGCGGGCGTCACGATCGGCGTGTCCAGCGCCTCCTGGCTCAAGCGCGCGGTGACCCGGTTCTGGTTGCGGCGCGCGGAGGGCATCGGTGACACGCTCGTGCGGACCGGCGGGAAGCACACCGGGTCCAGCCGGTTGCTCTACGCGCTGGGCTGGCTGTTCTGCTTCCGCGCGCTCAAGGCCAGGATCGGCATGCGGTACGTGCGGTACGCCGCCTCCGGTGCCGCGCCGATCGCGCCGGACGTGCTGAAGTTCTTCATGGGCATCGGGGTGCCGATGCACGAGGTCTACGGCATGACCGAGAACACCGCCGTGGCAACGGGAAACCGGCCGGGGCGGGTCAAGGTCGGCACGGTCGGCGAGCCGCAGCCGGGCATCGAGCTGCGGATCGACGCCGAGACCGGCGAGATCCTCACCCGGCACGGCGGCACGTTCGCCGGCTACTGGCGCGATCCCGACTCGACCGCACGGGTGCTGACCGACGGCTGGCTGCACACCGGTGACGTCGGCGAGTGGGTCGGCGGCACGCACGTGAAGATCACCGACCGGATGAAGGACATCATCATCACCGCGGGCGGCAAGAACATCGCGCCATCCGAGCTCGAGAACGCGCTGAAGACCTCCCCGTACGTCAAGGAAGCCGTGGTGATCGGCGACCAGCGGGCGTACCTGGTGGCGTTGATCGGCATCGAGTACGAGACGGTCGGGCACTGGGCGCAGCAGCGCAAGATCACCTACACCACCTACCGGGACCTGTCGGAGAAACCGGAGGTGCTGGAGCTCGTGCAGAAGATCGTGACCGAGGTGAACGGGAAGTTCGCACAGGTCGAGCAGATCAAGAAGTTCCGGATGCTCCCCAAGGAGCTCGACCACGAGGACGGCGAGCTGACCGCGACGCAGAAGGTGAAGAGGTCGGCGCTGGGCAAGACGTTCGGTGAGCTCGTCGAGTCGATGTACGGAGGAGCGAGCCGTGGATGAGTTCCTCCAGAGCCTGATCCGCGGCCTCGGCACCGGGTCGATCTACTCGTTGCTGGCGCTCGGCTTCGTGATCATCTACAAGTCGACGCAGGTGATCAGCTTCGCGCAGCCGGCGTTCATGCTGGCGGGCGCGGTGCTGGTGTCGTACCTGTCGCCCGCGGTGTCGTTCTACGGTGCGGTGCTGGTGGCCGCGTTGGTGATCGCGGTGCTGGCGCTGGGCGTGGAACGCACGGTGCTGCGGCCGATGGTCGGCAAGCCGGTGTTCGTGGTCGCGATCATCACGATCGGCGTGGACGTCGTGGTGCGGGTGGTGACGAACGCGTTCATCGGCCTGGACGTGCGCCAGGTGGGCGACCCGTGGGGGTTGGACACCGTCAGCTTCCTGGGCGCCGAGGTGCAGCAGCGGTACCTGGTGATGATCGGGACCACCGCGGTCGTGACGGTCGGGCTGTTCCTGTTCTTCCGGTACTCGCGGATCGGCCTCGCCATGCGGGCGGTCGCGTACGACCAGGAAGTGGCGCTGGCCCAGGGCATCTCGGTCGGGTCGGTGTTCGCGCTCTCCTGGGCGCTGGCGGGCGGGCTCGCGGCGCTGGCCGGGGTGTTCGTGGCGACCGGTGCCGGTGTCGACCAGCAGCTGTGGATCGTGGCGCTGAAGGCGTTGCCCGCGATCATCCTCGGCGGGCTGGAGTCGTTGGGCGGGGCGGTGGTCGGCGGGCTCGCGGTCGGGATCGTCGAGTCGCTCTTCGGCACCTACCAGAACGACTTCGCGCCCTGGCTCGGGCCGAACTTCGGGCTCGTCGCGCCGTACGCGTTGATGTTGCTGGTGCTGCTCGTCAGGCCGTACGGGTTGTTCGGCAAGCGAGAGGTGGAACGGCTTTGACTTCGTTCCCGCCCTGAAAGCGGGGATCCCACACGCCGGGTGGCGTGCAGCGCTCACGCGCTGTGCCTCACAACACGGGTTTCCTGTTTCATCGCCGATCGCGGAAGGGAGGACCCTTGCCGTCTGACATCAGCTCCGCAGGCATCACCCGAGGAACCTCGGGCTACGGCTCGACCAGCCGCAAGGATGTTCTTGGCCGCGTTGTGGTCCCGATCATGTCGGGCGCGGCATCCCGGACACGTCCAGTGCCGGGTGGTCAGACCGAGTTCGGCGAGCTGGTGCCCGCAGGCCGAACAGGTCTTGCTGGAGGGGTACCAGCGGTCGATCACAACCAATGTGCGGCCCGCGCGAGCGCACTTGTACTCGAGCTGGCGCCGGAACTCTCCCCAGCTCGCGTCGGAGATGGCACGAGCGAGGTGGTGACTGCGGACCATGCCCGAGATGTCGAGGTCCTCGATCGCGATCACCTCGGCCGATCGCACCAGGGCGGTGGTGATGCGGTGCAAGAAGTCCTGACGGGCGTTGCGGACCTTGCGGTGCGCTCCGGCTGCCTTGGCCCTTGCTTTGCTGCGATTCCGGCTGCCTCGTCGGCAGCGGGCCATGCGACGTTGGTAGCGGGCCAGCCTACGAGCCCTCCGGTCCAGATGCCTGGGATTGGGAATCCTTCTGCCGTCGCTGGTCACGGGGAAGTCGGTCAGTCCGAGGTCGACGCCTACAGCGTGCCCGGTGGGATCAGCGGCTTCGGGTGCTTCGGCATCCACGGCGAATGTCACGTACCAGCGTCCGTCCGGTTCGCGGGAGACCACGACCGTCGTCGGGTCCAACGCGGTGATGTCCACGTTGTCGAAGGACCACACGAATCGCAGCGGCGTGCTGGTCTTCGCCAGGTTCAGCACTCCGTCGCGCAGCCGGAACGCGGAGCGGGTGTAGTGCGCCGATTGACGGCCTCTGCGGGTTTTGAACCGCGGGTATCCAGCTCGACCCGCGAAGAAGTTTGCGAATGCGGTGTGCTGGTGCCGCAGGGTTTGCTGCAGCGGTACCGAGGACACTTCCGACAAGAACGCCAGGTCCTCGGTGCGCTTCCACCGTGTCAGCGCGGCGTCGGTCTCCCGACAGGTGGTCCTCTTTCCTTCGACGTGGTAGACGCCGTGCCGTTCGCTCAAGGTCTTGTTCCACACCAGGCGCACACATCCGAACGTGCGGTTCAACACCGCAGCATGCTCGGGATCCGGGTAAGCCCGGCACCGATACGCCGTCCGCATGATGATCAGCTCACTCAGGGAGACACGATGAGGACGCCAGCGGTCTGCCGGCTCGCGGGCTCTGCGCCCGCCCGGACACCTCCTCCGCCTGCATGGAGTGGATTCCGCCGGAGGCTTTGGTGAAGGGCCGAGCGGCCGTGAAGGGTCGTCCTGAGCTGTACACCTCCTACGGGCAGGACATGGCGTTCCTGAACACGCGGCCCAAACGCGCGTGGTCGGGTGGCCTGGTCGTGTTCGCGCTCGTGGTCCCGTTCCTCATCACGGACGACCTGCTTCAGCTGCTGGCGACCGGGTTCGTGGCGGCGATCGGCGCGATCGGGCTCAACATCGTCACCGGCTACGCGGGCCAGGTCTCGCTGGGGCACGCGTTCTTCCTCGCGATCGGCGCGTACACCGGTGCGGCCTTGTCCGGGTCCGAGACCGGCCGGGTGATCGGGTTCGGCATCACGTCGCTGCCGATCTGGTTGCTGGCCTCGGGTCTGGTGGCGGCGTTGTTCGGCGTGCTGGTGGCGCCGGTGGCGGTGCGGTTGCGCGGGCTGTACCTCGCGATCGTGACGCTGGGGCTGGTCTTCCTGGGAGAGCACGTGTTCCGGGAGTGGACGTCGCTGACCGGCGGGCCCGGTGTCGGGCGGCCGGCGGCGGTGCCGGAGCTGTTCGGGGTGCGGCTGGACCGCGACAGCGCGTTCTTCACCGCGGCCCAGCAGCTCTACCTGGTGATGTTCGTGCTGCTGGTCATCTTCGCGGTGCTGGCGCGCAACCTGGTCCGCTCACGGGTGGGGCGGGCGTTCGCCGCGGTGCGCGACCGCGACCTGGCCGCGTCGGTCATCGGCGTGGACCTCACGAAGTACAAGGTGCTCGCGTTCGCGGTGTCCTCGTTCTACGCGGGTGTCGCGGGCGCGTTGTTGTTCGTGGTCAACGGGTTCTTCGACCCCGGCTCGTTCAACCTGCTGTTGTCGGTGCAGTACATCGCGATGGTGCTCATCGGCGGCGCGGGCACCATCTCGGGCGCGATCATGGGCGCTCTCTTCATCACTCTGCTGCCACGCATCACCAGGGAACTGCCCACGGTGCTGCCGTTCATCAGTGGTGACGCCACCGGCGCGATCACGGTCTTCCAGGTGGAGGCCGTGCTCTACGGCGTGCTGATCATCGTGTTCCTCATCGTCGAGCCACGCGGGTTGTTCGGCATCTGGGTTCGCGTGCGCAACTACTGGCGCACCTGGCCGTTCTCGTACTGAGGAGAGAGTCGCCATGCTTCGGAAGAGATTCGCTGTTGTGTTCGTGGGCGTGCTCGCGCTCGCGTCGTGCCGAGGGGGAGACGGCGCGGCGCCACAGGAGGGCGCGGGCGGCATCAAGGTCGACTTCGGGGTCACGAAGGAGGCGTGCCCGCAGGCGGTCGACAAGACCAAGGGCTGCATCTACCTGGGCACCATCTCGGACCTGACCGAGGGCCCGTTCAAGACGCTGGCCGTGCCGATCACCGACTCGCAGAAGGCGTTCTGGAAGCGGGTGAACGACCGCGGCGGCATCGGCGGGTACGAGGTCGACGTGACCAAGTACGTCAAGGACAACAAGTACAACCCGCAGATCCACAACCAGGTCTACCAGGAGATCAAGGGCAACATCCTGGCGTTGACGCAGACGCTGGGCTCGCCCACGACCGCGGCGATCCTGCCCGACCTGGAGAACACCCAGATGGTGTCGGTGCCGGCGTCCTGGACGTCGTTGTGGGGCTTCGAGGAGGTCGTGCTGGAGTCCGGCGCGAACTACTGCGTCGAGTCGATGAACACCGTCGACTACGCCGTGGAGAAGCTCGGCGTGAAGTCCGTGATGGCCGTGCACCTCGCCGGTGACTACGGCGACGACGCGGCGGCCGGTGCGAAGATCGCGGCCGAGAAGCGCGGGCTGACGTTCGAGAGCCTGACGACCCAGACCGGCCAGGACAACCAGGGAGGCGCGATCGACGCGGTGGTGTCGAAGAAGCCGGACCTCGTGGTCCTGACGACCGGCCCGACCGACGCCGCGGTGATCATCGGCCAGGCCGCTGCCCGCGGGTACAAGGGCAAGTTCATCGGCACCTCGCCGACGTGGAACCCCGGTCTGCTGAAGTCGCCGGCCGCACCGGCGATCAAGGCGCTGTACTACCAGTCGGCGCCGTGGAAGGCGTGGGGCACCGAGTCCGTCGGCCACACCGCGATGCGCGCCGCGCTGACCGGTGTCACGCCGAACGACGGCTACACGGCCGGCTGGGTGTGGGCGTACCCGTTGAAGGCGGCGCTGGAGAAGGCCGCGGCGAACAAGGACATGACGCGTGCCGGAGTGCTCGCCGCCGTGCGTCAGCTCACCTCGGTGGACTACGAGGGCATGCTTCCTTCGGGTGCGGGCAACTTCGCCGCTTCGCCCCAGGACGCCGCGTTCCGCCAGACGCTCATCTACAAGCCGGACGACGCCGCTGCGACCGGGGTTTCGCTGGTGGAGGACTTCTACACCGGTTCCACGGCCAAGGACTTCAAGTTCGAGAAGCCCTGCTACCAATGAACCGAACGGGTGACAGTGGCATCTGATGCGGCTCGTTCGTGGCTAGTCTCCCTGTGAGCGGGTTGCAGGGAGGTTGCAGCGGTGTTGACGTGCGTTGAAGTTCGCCGTGCTGCGGGAGGCCTCCGGTTGTTCGTCCGTCCCCCGGCCGCGCTGCGCTGGAGCGCGCGGCTGGGGTACGAGCGGGTGTCGGAGCTGCTGACCGCGATCCGTGCCGCCGAGTCGTGCTCGGTGCCGGACGTGGAGCTGACGTACGTGCCGGACCAGCGGACCGGGGAGGCCGAGCTGGCGTGTGCCACCGGGTCCGTGCTGCTGGCCGCCGCTGAGGTGTTGTTGCTGCACGACGCTCTACGCGCACACATGCCGGACCGGATGCGACCTCTCCCGGCCTAACCCCCTGCTGCCTCTGGCGTCTGCAAGTACTGCCAACTCTTGATCAAACCGCCTTCAACCACAACCAACCTGTCGCCGCGTCCCCGGTTGGGAAGCGACGGGTTGGTTGTAGTTACGGGCCTGATGATCTTGGGTTGGTAGTACTTGCAGACGTCGGTGGCTGACGGGTGGGGTCGTAGTTGCCCGTTGGGGCAGCCGATCGTGTCCGTGGGGACGTCACTGCGCTGGTCGATTGCCGCGTGGTGGCGCGCGATCGTGGTGGGATGATCCACGAGGTCGATGAGGCGCTGCGGCGGCTGGTGCGCGACGAGGCGTTGCGCGGGTCGGACCTGGACGTCGCGTTCGACGCGCCGACCAAGGACTGGGCGGCGCGGCGGAACGCGCCCACGGTCAACATCTACCTCTACGACATCCGCGAGGACATGCGGCGGCGCCAGCGCGGGCTGCTCAACGAGTACGACGCGCAGGGCCAGGTCGCCGCACGCCACCTGCCGCCACGGCACATGAAGCTGTCGTACCTGGTGACGGCGTGGACGCAGCGCGCGGAGGACGAGCACCGGCTGCTGTCCGATCTCCTGGTGGGGTTCCTGCGTTATGACGCGGTGCCACCTCCGCTGCTGACCGGGTCGCTGGAGGCGCTGGCGTTGCCGGTGCCGATGACGGTCGCGTTGCCACCACCCGAGGACCGGGCGTTCGCGGACGTGTGGAGTGCCCTGGGCGGTGAGCTGAAGCCGTCGCTGGACGTCGTGGTGTCCGCGCCGGTGTCGTCCGGACGCAAGGTCGACGCCGGGCCGCCCGCACGGGAGGGCGTGCAGCTGAACACGGGCGCGGACCGGGTGCGGCACACCGTCTCCGGCGACGGGGTGTCGATGCGCCGGGTGACGCAATGATCTTCGAGCGGCTGGCGGCGCTGGAACGGCGGATCAGGGCGGCGGTGGCGTCGCGCCGGGCCACCGACCCGAGCCCGGACGACCCGTTCCGCGGGCTGTACCTGTCCGACGAGGTGATCGACGCGTTGCTGGACAGTGCGCGCGACCCGTTCGCGGGCTACGTGGACGTCCCCGCCGACGGACGGCTGGGGCGGCTGGCGTCGGTGGCGTGTCTGTCCGATGTGGACGTGGAGCTGCTGCTCGTGGCGCTGGCACCGGACGTGGACAGCCGGTTCGAGCAGTTCTACGGGTACCTGAACGACGACGTGACCCGCCGCCGGGCGACCGCGGGGCTCGCGTTGCGGTTGTGCGGGCTGGCGGAGGCCTCGTCCACCGGGCGGTCGCGGCTCGACCGGGGAAGTCCGCTGGTGCGGTCGGGGATGGTGGTCGTGGAGGACCTGGACCGGCCGCTGCTGTCGCGGTCGCTGAGGGTGCCCGACCGGGTCGTCGCCCACCTGCTCGGCGACGACCGGCCGGACCCGCTGCTGGCCGATTTCGTGACGCTGCCGGGGGAACCGGTGCCGCTTCCGGGTGCCGAGAGGCTGGCGCGCGGGATCGACCGCGGGGTGCGGCTCGTCTACCTGCGCGAGCATCCTGGTGGCGGGGCGGCCGAGCTGGCCGTTGCCGCGTTGGCACAGGCGGGTTTTCCGGCGCTGCTGGTGGACTCCGCGCGGATGACCGACGCGGTTGCCGTTGTGCGCGAGGCGTTGTTGCGCGGCGCGGGCGTTGTCGTCGGTTCGGTCGACCCTTCCTTCTCCTTGGACCCGCTGTTGCACGACTCGGTTCCGCTGGTGGCCTTCGGCTCCGGTGCCTGGGAACCGCGCTGGACCCGCGTGCCACCGTTGCAGCACGAGGCCCTCCAGGTGCCTTTCGACGTGCGGGCCTCGCTGTGGCGCACGTCGTTGGAGGGCAGGCTGGCCGCGGGCGTGGACCCGGCCGAGGTCACCGCGCACTTCGTCCTCGGTCCCACGCAGATCTCCCGTGCCGCCTCCGCCGCCGCGGTGTCCGCACTGGCCGAGGACGGCGCGGTCGACGTCCGCCACCTGCGCGCGGGCGCCCGTTCCCAGAACGCCGGCGGCCTGCAACGCCTGGCCCGCCGCATCGAACCGGCCGTCTCGTGGCGCGACCTCGTCCTGCCCGTCCCGGTGACCTCACTGCTGCAGGAGCTGGCCGCCCGAGCCCGCCACCGCGACCGCGTGATCGACGAGTGGCGCATGCGCCCCGGCGGCGGCCGGGGCCGGGGCGTGACGGCGCTGTTCGCCGGCGACTCCGGCACCGGCAAGACGATGTCGGCCGAGGTGATCGCCGCGTCTCTGGGCCTGGACCTGTACACGGTGAACCTGGCGACCGTCGTCGACAAGTACGTCGGCGAGACCGAGAAGAACCTCGAACGCATCTTCGTCGAGGCGGCGGGCGTCAACGGCGTGCTGCTGTTCGACGAGGCCGACGCGATCTTCGGCAAGCGCTCCGAGGTCCGCGACGCCCACGACCGCTACGCCAACATCGAGAGCGCCTACCTGTTGCAGCGCATGGAAACCTTCGACGGCATCGCGGTGCTCGCCACCAACCTGCGCGCCAACCTGGACGACGCCTTCACCCGCCGCCTGGACGTCATCGTCGACTTCCCCCTGCCGGACGTCCCGCTGCGCCGCAACCTGTGGGACCGCTGCCTGGGCGACGCCGTCCCGCGTTCGTCCGATGTGGACCTGGACTTCCTGGCCGGTTCGTTCGAGCTGGCCGGCGGCCACATCCGCTCGGCCGCGGTGACCGCCGCCTACCTGGCCGCCGCTGGTGACCACGTGGTGGGCATGGTCGAGCTCATCGGCGCCGTGGCCCGCGAGTACCGCAAGCTCGGCCGCCTGGTGGGCGAGCGCGAGTTCGGCCGCTACCTCGACTTCGCCACCGAGCGGTTGGTGGGGTAGTGCGAGCGTTCGAGTCCAAGCCGTTCAACCAGAAGAAGACCGTTGCCGCCCGGTCGTCGGCGGCTCCGAGTGGACTGCACGCGCTCCAGCAGTCCGCGGGGAACCGCGCGGTGGCCGGGATGCTCGCACTGCAGCGCGTCGACCACCTGCTGGAGTCTCCTCCGTCAGCACGCGGGGAGGTCGTCGAAGGCACGTTCGACCGCGATCCCCTCTACCTCGACAACTTCACGGGTGGCGGGTTCGAGGTGCTGACCGGGTTGTTCCGGTTGATGTACGCGGACGGGCGAGCGGTCGACTTCCGATACGCCGATGTGATCCGTCAACTGAGGACGGGTGCATCGGAGTCCGCGCTGTTGCCCGCGGCTGCGGACACCGCGGCGGGTAGCCGCACAGTGCGGCTCGCCGTGCGTTTTACTACCGGAGCACGGACACCGGGCTGATCCACCCCGCACATGCCACGCGGGAGACACTTCCCCATCTGGCGGCGTTCCTCGACGCGGTGGAGGTGGCGCGGCCGCAACGGGAACGCGAGATCATCATGGCCCTGATCGACGGGGCGGTGGCCGTGCACGGTGTGGCCAGCGGTGTCGTGGCGTCGTCACGCCTGGCCGACGCGGTCAGCAGGCTCAGGACGTCACCGCCGGCCAGCAGACCTCGGCGCGGTGGCGAACCCCGGACGATCTCCGGTGGCAGTCGCCGGGAACGTGAGCTCAGGACTGGTCACCGGCCGGCGAACGACAACGCACTCGACGACGAGGTGGCCGCGGCGACCGGTACGAGAGGCGGCGGACGGACCACGGCGTCCGGAACGCCGCACGAGGTTCGTCCCGCCGGAGCGGACCGCCCGCACAACGCTCACCACACCAGCACCCGCGGTTCCACGAGGCACGACCACCAGGTCGGGATGGCGAGGAGCCAAGCCGACCAGCAGGCGGCGGCCGAACGCGCCGCAGCCGCCCTGGCCCGTGCCCAGGCACGCAGGATGGGCGGGCGGGTGAACGAGGTGCTGAACCGCGTGCGAAACCTGCCGTCCGCCGCGATCGAGACCCTGCGGAACATTCCCGGCAAGTGGGCGCGACTCGACGAAGTCGCTCGGATGCTCCAAGCCGAACGCCGCGGCTACAACCTCAACGCGGCGCTGCTCGGCGAGTCGAGGGTTCCCAGCCAGTTCACCAACGAGCAGAGGCGGGTGCTGGAGGAGGCCCTGACGGACCTCGCGGACCTCCTCGACCACCACATCCACCTCATCGGCCGCTGAGTGCCCGCAAGGGCAGCGGTCGGTGCACCTCTGGTCGCTCCCGAGCATCTGGCCCGCGCCCTTCTGGTTGGTGAAGCTGGACACCTCCGGGATCGGGTAGAGGGGGCGCGACATGCGCGGGTTTGAACACGAGTCCGAAACTTCACCACGCCCCAAGGGCGACCGGCTCTCGCACGACGGGTCCGACCTGCTCGGCAGAGCTGCTGCCGCGAACCGACCCGAGGTCCTCGGCGCTGCGGGCTTGCTCGACCTCCAGCGAGCCGTCGGCAACGCCGGCGTCACCTCCGTTGTGGAGGAAGAACGCTCACCGGTGCACGGGGTGCTGTCGTCCGGCGGCGCACCGTTGGACGCGAACGTGCGTGCGGACATGGAAGGGCGCTTCGGGCAGGACTTCTCCGACGTGCGCGTGCACACCGACTCGGCCGCGCACGCGTCGGCGCAGTCGGTGAACGCCCAGGCCTACACCGTCGGGTCGAACATCGTGTTCCAGAGGGACAGGTACGACCCGGCGTCTGCTGCTGGGCAGCACATGCTGGCGCACGAGCTGACGCACGTGGTGCAGCAGCGGTCCGGGCCCGTGGACGGAACGGATGCCGGTGGCGGGGTGAAGGTGAGTGATCCGTCGGACCGGTTCGAGCGGGAGGCCGTCTCCACCGCTGACCGGATCATGTCGGCGCCGTCGCCAGTCGCACCTGTGCAGCGTTGCGAGGACGAGGCGGTGCAGCGGGTGGTGGTGCAGAGGGAGGACGCTCCGCCCGCCGAGGAGGAGGAACCGGCCGCGCAGACGTTCGTGCAGCGGGCCGAGGAGGAGGAAGAAGCCGCGGAGTAGCTCCTCATGCGGCTTTTCCTGCCTTCTTCACCCGCTCCCAGAGGTGGTGTGCCCACTCGGCCAGCGGCAGCTCCCAGTGCTTGCCGATGTTCTCCTTGGTCGCGAGTTGGCGCAGGTCCCAACCGAGCTCGACGCCGTCCAGCAGCACCAGGTTCGCCAGGTCCTTGCCCGTGGTCTTCTTCTTGGGGTCCATCCGGCCCTCGTACGTCGACCGCGGCGCGAGGATGAAGTCGGCCTTCTGCCCGATCGCGGGATCGGACCGCACCTTCCTGATGAGCGCCTGCAGCTTGGCCGAACACGCTTGGCAGGGGCTGGCGCTGATGGCGAACACGAGCTGCGGCCGGTTGCCGGCGGCGACCTCCTTGCGAACCGCCTCGAGTGCGCGGTCCCAGTGCTGCTCGATCACCATGTCCTCGGCGTGCCTGCCGCCTTTGCCGCCGGTGGCGGACTCGTTGTACTCGCATTGGCCGATCATGGCGCCGTTGACCGTCACTGCGGCGATGACGTAGTTGCGCACGCCTTCGGCCTTGTTCTCGAACGCCAGCTTGAGCTTGTCGAGGTCCGTGCCTTCGAACACCTCGGCCAAGGGGATGCGACGCTGGTCCGGCGGGCTCGCGACCGCGGTCAGCTCGGCCGTCTTGCCGTCCTCGGACGCCGTCAGGTCCAACCTCTTCAGGCCCTGCTCCCGGTAGCGCCGGCGGATGCCGTCGAGCACCGGCTTGGCGGCGTCGATCCGGTCGAGACCGCGCAACTCGGTGTGGGCGTCGCGAAGTGCGTCCGATTTGACCTTCTCCGGCCCGGCTTTCGCGTCGTCCCCCTTCCCGTCCTTCTTGCCGGTCAGCTTCCCGATGAACTTCTTGCCCGCCTTCACGATCGTCCCGACGACCTTGTCGATCACCTTCCCCACCGGTGCCTGGATCTTCGCCAGAATCGACTTGATCTTCTCCGAGATCCCGCCCAGCCCCAGCAGCGACGCCAGGAACCCGAGCACCACCGGCACCGCCTTCGCCAGCGTCTTCTCGATCAACCCCGCCACCGCCCCGACCCCGCCACGAGCGATGGACTCGACCGAGTCGAGCACCGAGTCCACGAACTCCTTGATCTGGGCGGCGCGGTCGACGAAGAACATGACGACGTCGTAGATCGCCTTGCACGCCTTGACGAAGGCGGCCGCAGGGTTCAGCAGCGAGATGATCCAGGTGATGCCGGCCTTGACGATCTTCTCGACCACGAACTCCTTGATCTGGCCGAGCACCATCTCCTTGAGGTCGCCGAGCTTCTCGACCACCCACTTCCACAGCCCGGGCAGGCCTTCGGTGACGAGGATCTTGACGACCTCCAGCTTCGACTCCAGGAACGCGAGCACCGGCTCCGGGATGACCCTGGTGATCCGCGCCCGGACCGAAGCCCAGGTCAGGCCCAGGATGGAAAGGATCATCCGCAGGATGCCGCGTGCGTCGAAGGTGTCGGGGATCTCGATGCCCGCCGACGCGAGGTTGCCGAGCAGCCAGCCCTTCAGGCCGCTCTTCAGGTGCTCCAGGATGTTCGCGGCGAAGTTCATGACACCGGTCTTCACCGCATTGACCAGGTTGCCGAGGAACTCGATCGGCTTCGCGATGATCAGCTCCACGGCACCGGCCGCGCGGGACAGGACGCCGAGCAGCATGTCCTTCAGCTTCACGATCGTGTCGATGGCGCCGCCGACGGCCTCCTTCGCCTTGCTCCACAGGCCCTTGTTCGCCTCCTGCAGGGCCTTGATCTCCTCGTCGACGGCGTTGCGGGCCTCGACGTAGCGGGAGGCCAGGTCCTCGACCAGGGACTGCTGCTTCTCGTCGACCGAGCTCTCCAGCGAGTCGAACTGGTCGCCGAACGAGTCCGCCGCCTCGCCGGCGATCTTGCGCAGCGACGGTGCCTGCGATGCCACCTTCTGCTTCACGCGTTCGCGGCCGTCGGAGATCAGCTGCTTGGCTTCGCCGAGACGGGCGCCGATGTGGTCGGCGATGCCGTTGATGACGCGCAGCATGTGCTGCTCGTAGACCTTGCGCGACTCCAGGAACAGGGCGTTCGCCTCGGCGGGCAGGTCGGCGAAGAGGTCCCACGTCCAGCGCGCGGCGCCCTCGACGCCGGAGTAGCGCTGCTCGCGGTAGCGGCCCATGCGGGCCTTGTGGTCGGCGGTGAAGGCGGCCTTGGCGTCGGCCTCGCCCTTCTCGAACTGCTGGGCGACCTCGCCGTCGAGGGCGTTGAGCACGCCCTCGACCTTGGTCTTGGTCTCGTCGAAGATCGCGCGGATCTCACCGGTGATGCGCGCGCGTTCCTGTTCGTCCTTGGTCTTCGTCGCCGAACGCTGGGCCGCGCCGCGCGTTCCGTCCGCGGTCCGTGCGGTGTTCATGCCGGTGACCGCGGCGGTTCCGGACGCCTGGGCCGCTGCGGCGGCCGAGGTCAGCGTGGCGGCTTCGGCGGATCGGACGGCGGCGGGGGCGGTCGCGGTGTGCTGCTCGCCCTCCTCCTTGGCGGCCAGCGCGCTCTGGAACTCCGGCTCGTTCGACTCGGCCAGCTGCTGGTCGGTGACCTTCGCCTCGGCCATCTTCGCGTGCGTCTCGCACTGGTCGGCGCGCAGGTCGGTCTGCTCGGCGGGTGCCTTGACCGGCACGGCTCTCGCGGTGTCGACCGGGGCGACGGGCGCGGTGGGTGGCTGGACCAGTGGCGTGACCGGCTTCTCGACGGCCTTGCTCGCGTCGGGGGTTTCCTTCGTGCGGTCGGTGACGTCCTTGGCCGAGGTGTCCTTGCCCGCGGCCACCTTGCCGATCACCTCGGACTTCACCGCGTCGGCCTTGCCGGAGGTCGCGAACTTGTCGGCCTCGTCCAGGTTCTGCGGTGCCTGCTTGGCGATCGCGGCGTTCACGGCCGCGACGAAGCCCGCCTTGTCGAAGCCCGCCGGTTTCGCGGCGGCCATCTTGTCGGCCTGGTCGGCCTTGGCCTGGGCGTCCTTGTCGTCGGCGGGCGCGACGGCGGCGTCCTGCGACTTCTTGACCTCGGCCGCGGCCGGTGGGTGGGCCTTGGCGGTCTTGGCCTTGGCGGCGATGTCCGTGCGCACCGAACGGAAGCGCGGGTCGGTCGCGGGCGTGACGGCCGGCGGTGCGGGGGCCGGCGCGGGGCAGGCCCGTTGGACGAGCAGGTCGGAGACGGCCGCGTTGCCCGCCGCCTGTTGCAGGCGCAGCAGGGCCGGGACCGGTTTGCGCACGCGCGGAACCGGCCGGGGCGGCTGGTCGGCGCTCCCGGTGCGGTCGCGGTCCCGTGGCATGCGTTCACTGTTGGTGCGGCCGACCGCCTCCCACAACGTCCATAGGGGCAGTCACCAGGGCGCAGGTGAGCTGGCGTCCGGCACCAGCACCCGCGCCTCGCCGCTGCCGTCCGCGGGCTCGGCCCACACGTCGTTGGTGCCGTCGTCGCGCTGGATGCCGTAGGCGACCGTCCGGTCGTCGATCCAGGCGGGCTGGTCGTCGACGTTGCGGGTGTCGGCGAGCGGGGTGATCTCGCGCGTGGCGAGGTCCAGCACGGACACGCGCCAGCCGCGTTGCGGATCGCCGCCGACGGCGGCCTTGTAGGCGATCCGGGTGCCGTCGGGGGACAGCGACGGGCATTCGACGTTGTCCACCAGCGTCCGGGCCTTGCGGGCCGCGAAGTCGCCCTCGACCAGGTAGCGGTGCCCGGCGGTGGACATGGTGGCGTAGAAGCGGTTGTCGTCGGCGGTGAAGGTGACGCCCCAGAAGTTCGCGTCGGCGGGCAGCTGCGCCATGCCCTCGACCGAGAACTCCTCCAGCGACCGCACGAGCGCGCCCGTCTTCGTGTCCAGGATTCCGGTGCTGGTGGAGAAACCATTGGCGGCGTAGGAGTGCCCGTCGACGAACAACGTCCACGCCACCATCCGGCCGCTCGCCGAGACACGGGTGCGGTTGGGGAACCCGGTCAGCGGGACGGTCCGCAGCTCGTTCAGCCGGGAGTCCAGCACGGCCAGCTCGCCCGCCTTGAGCGCGCCGACCGGTCGCAGGCAGGAGATGGTGCCCGCGGCTCCGTAGACGCGGTCGCAGCGTTGCGCGGTGACCTCCCTGGGGCCGTTCGGGTCGGTGCTGGAGACGGTGGTGAGCTGGCCGTTGCTGAGGACCAGCAGCCGCGGCCCCGACGCCGACCCGGCCGAGATCGAGTGCGCCGCCTCGCCGGTGGACGCGGACAGCGCGGTGTAGCCGACCGCGACGCCGGCCAGCAGCACGGCGGCGAACACGGTGATCAACAGGCGGTGCTTCACGCGCGCACCTTCCTTCCTCCGAGCAGAACGGCGGTGGCGACCAGCGCGATCACCACGGCGACGGCGGCGGTCCTGGTGGCGATCTCCGGGCCGAGGAACTGCCAGGCCAGGCCGAAGAGCACCGACGAACCGAGGTAGGCGAGCGCCTGTCCACTCTGGATCAACGCGATCCCGGTGGTGCGCAGGCGTTCCGGCAGTACCGGACCGGCGAGCGCCATCAGTACGCCGTCGGTGGCCGCGTAGAACACGCCGTACAGCACCACGACGGTGACCATCAGCGGAACGCCGCCGATCGGGCCGTGCAGCAGCAGGTAGACGGCGGTCAGCGCGCCGTACCCGCACAGCATCACCTTCAGCCGGCCGACGCGGTCCGCGAGCGCGCCCAGCGGTGCGGCGAGCAGCAGGTACACCAGGCTGGTGCCGACCGCGAGCAGCGGGAACCAGCCGAACGCCAGCCCTTCCCGCTTCTGCAGCAACAGGTACACGAACCCGTCGCCGATGGTGACCAGCCCGAGCAACGCGGCGGCGGCGACGATCCTGCGGACGGCCGGGTCCTTGAGCAGGGCGAGCTTGAGCGGTTCCTTGCGCTGCAGCGGTTTCGGCCGGTCCCGCACGTAGAGGACCAGCACCAGCACGCCGAACGCGGCGATGCAGAAGCTGGTGACGAACACGGCGTCGAACGACTGGGCGGAGGCGGCGAGCACGGCCATGGCGACCAGCGGCCCGGCGAACGCGCCGATGCCGTCCATCGCCCGGTGCACGCCGAACGCGCGGCCGAGGTCACCGCTGGGGGTGGACAACGTGATCAGCGCGTCCCGCGGTGCTGTGCGCAGACCCTTCCCGGCGCGGTCGGCGGTGATCACGAGCCCGAGCGCGGCCGTGGAGTTGCCGACGGCCAGCAGTCCGAGCTTGGCCACCGCGGAGAGCCCGTAACCGAACCCCGCGACGGCCTTGCGCCGGTTGGTGCGGTCGGCGAGGTAGCCGCCCGCGAGTCGCAGCAGCGTGGTGGCGCCGGTGTAGACGCCGTCGACCAGCCCGTACGCCGCCGGGCTGAGCTGGAGGCCGATGACCAGGTACAGCGGCAGGATCGCGGCCACCATCTCCGACGAGACGTCGGTGATCAGGCTGACCGTGCCGAGCGCGAAGACGTTGCCGCTCAGCCCTTTCCAGTTCGCTGTCTTGGGTCGGTCTACTGTGGATAGGTACACATCGGCCTCCAGCCGGTCAGCTACGGGCGTGCGTCAGTGGCAGTTGGTGGTGCCGCTGTCGGTGTAGGTCTTGCCCGACTCGGGCACGAACTGCCAGTCGAAGCTGTTGCTGTGCAACGTCAGCTTCAGCACACCGCGGGTGCCGGTGTTGCGCGCCTCGCTGTTCGGCTTGATCGTGCCGAACCCGTAGGCGCCCGCCCCGCCCATGCCCGCGACGAACGTCCTGATGCCGCGCGCCGTGTCGAGCGCGCCACTGGGGTTCTGCGGGGCGAACCGCTCGTACTGGTGGTTGTGGCCGAACAGCACCACGTCCGCGTTGTAGTCGTACAACGCCTGGAACAACGGCCTGGTCGCCGTCGACGGCGCGTGGTTGGCCCCGCTGGTGAACAGCGGGTGGTGCCAGTACGCCGCGGTGCACGGCTTCGTGCTCGCCGCCAGGTCCTGCCGCAGCCACTGCTCCTGCGCGCTGCCCGCGGACATGCTGATGTTGGAGTTCAGCGACACGATGTGCCAGTTGCCGATGTCGTAGGAGTAGTACCCGCGCCCGGAAGGCCCGGCCTGCGCCCCGAAGTAGCTGTAGTACCCGGAGGCACCGCTGGTGTGGTAGTCGTGGTTGCCCGGCGAAGGCCGCGTGCGCGCCTTGTGCCGCCCCCACGTGGGCTCGTAGTAGGAGTTGAACTGCGACAACGTCCCGTCCGGGTACACGTTGTCCCCGGTCGTCCAGACGGTGCCCTGGATGTTGTCCAGCAACGCCGCCGTGGCGCTGTCCCCGGACCCGGAGTCCGCGATGTCCCCGGCCCCGACGAACACCGGGTCGTTGCCCGGCTGGGTGCTGCCGGTGGTGATCACGAGCCGCGGCGCCGTCGTGGCCCCCGACTCCCTGCTGTCGTAGTCGGCCCCGTCCGTGCTGCTGGACGTGACCCCGATGCTGAACGTGCCGTTGCCGGTGACGTAGCTCGTGACGTCGACCTCGTACCAGGCGTTGCGCACGACCGCCCCGAGCGACCCCAGGGTGGCGCCGTCGATGGCGGGCTGGGCGTTGGCGGTGACAGCCGCCTCCGACCAGCTCGTGCTGCTCATCGCCCGGAACGTGCCCCCGTTCGGGCTCTCCGCACCGGAGACGTCGTCGGTGTGGATGCGCAGCTTCGCGTTGGTGACGGCCTCGGTGAGCCCGGAGACGGCGAACTTGAGGAACATCCGCTTGACCGGCGAGTTGTCGACGCCGAGCTGCCCGGACGTGCCGTAGTTGGTGCTCGCCGCGGCGTTGTCCACGTACGTGTCCGCGGTGGCGGTGAACGTGGTCGTGGCCGCTTGTGCTGAGGTGGAGGCGGTGATCGTTGCCGCCGTGATGACGACCGTGGTGAGCACGGCCAGTGGAGCCCTGCGACGTGACATGCCAGCGCACTTCCTTGTTGGCGGACATGGGCCGTCGGGAAGGGTAGAGCGCGGTTCATCGGTGGCTGATGATCGTACGAGGGCGGTTTGGTGAACGCCGGAAGAACGACGTTGACGGTCGTCGCGGTGTTCGCTCATGAGCTCGTGGTCGCCCTGAGCGCCCCGGCGACCGGCGTTGCCCTTTCGGGCAGCCGCTGACTCCCTTCGGCACCGCCGCGTGGTCGTGTCGGGTTCTCGCAGGTCGCCGGAGCATGTGTCGAACAGGGTTCCGAACGATCTGGGAGGCCGTCGATGCCCACCTATCTCTCGCCGGGCGTGTACGTCGAGGAGGTGGAGGCGGGCGCCCGCCCCATCGAGGGCGTGGGCACCGCCGTCGCCGCGTTCGTCGGGTTCGCGGCCAAGGGTGAGTACAACACCCCGACGCTCGTCTCGAACTGGGCGCAGTACACCGAGAAGTTCGGCGACTTCGCCGAGGGCTGCTACCTGCCGCTGGCGGTCTACGGCTACTTCCTCAACGGCGGCAACAACTGCTACGTCGTGCGCGTCGGCGGCGACAAGGCCACGCCCGCGCTGCCCGCCGGCGCCCAGGGCGTGCTGGGCGGCTACCGCGTCGCCGCGCGCGAGCTGTCCGCCTCCTCGCTGTCCGTCGAGGTCGCCGACCCGGCGGGCGAGAACCCGCCGGACGACCGCTTCTCCGTGGTGGTCAAGGACAACGGCAAGGTCGTCGAGACCCACCAGGTCTCCGCCAAGCGCGGCAAGGAGAACGTCGTCACGGTGGTGAACGCGGCCTCCAAGCTGATCACGATCACCGAGGTAGCCGGCGCGCCGGTCGCCAAGCCGGACAAGACGTCCGTCGCGTTGCGCGAGGCCCAGGCGCCGCCGCCGGTGCCGCGCAAGGTCGTTCCCGACGACTACGTGGGCGACGTCGCCGACCGCACCGGCTTCGGCGGCCTGGAGGCGATCGACGAGATCACGATGGTCTCGGTGCCCGACCTGATGAGCTCCTACCAGCGCGGCCTGATCACGCTGGAGGGCGTCAAGACCGTGCAGGCGGCCATGATCGCGCACTGCGAGCTCATGGGCGACCGCATGGCGATCCTCGACCCGCCGCCCGACCTCTCGCCGGACCAGGTGAAGAACTGGAAGCAGACCGAGGCCGGCTACGACTCGAAGTACGCGACGCTGTACTACCCGTGGGTCAAGGTCTACGACCCGTCCACTTCGGACAACGTCTTCGTGCCGCCGTCCGGCCACATGGCCGGGATCTGGGCCCGCACCGACGCGGCGCGCGGGGTGCACAAGGCCCCGGCGAACGAGGTCGTGCGCGGCGCCGTGGCGTTGCACACCCAGCTCACCAAGGCCGAGCAGGAGCTGCTGAACCCGATCGGCGTGAACTGCATCCGCTCGTTCACCGGCCGCGGCATCCGCGTCTGGGGCGCGCGGACGTTGTCGTCGGACCCGGCCTGGCGCTACCTGAACGTGCGGCGGCTCTTCAACTACCTCGAGGAGTCCATCATGGACGGAACGCAGTGGGTCGTCTTCGAACCGAACGACGACGCGCTGTGGGCCCGCATCCGCCGCACGATCAGCGCGTTCCTGGTGATGGAGTGGCGCAAGGGCGCGCTGTTCGGCCTGACGCCCGACGAGGCCTTCTACGTCAAGTGCGACCGCGAGACCAACCCCGCCGAGGGCATCGACCTCGGCCAGGTGATCTGCGAGGTCGGCGTCGCACCGGTGAAGCCCGCCGAGTTCGTCGTCTTCCGGCTCGCCCAGATCCAGGGCGGCACCAGTCTGGTCAACGAGTAACCGAGCAGAAGGCGGTTCAGCGTCATGGCACTCCCCGAACTCGACACGTCGGTCGGCCACTCGTTCGGCCTGGAGGTCGACGGCATCACAATCAAGCAGATCTCCGAGGTGACCGGCCTGAAGATGGAACAGGACGTCATCGAGCTCAAGCAGAACACCTCCGACGGCAAGTACGTCGTGAAGAAGCTGCCCGGCCGCAAGAAGGCGGGCGAGGTCACCTTCACCCGCGGCCTGACCGGTGACAACTCGTTCGAGAGGTGGGTGAAGGACGCCCAGTTCGGCAAGATGGGCGCCGCCCGCAAGAACGGCGTGGTCGTCGTCTACGACTACGAGGGCCAGCCCATCAAGCGCTACAAGATCATGCACGCCTGGCCGAAGTCGCTGGAGATCGGCTCGCTGAAGGCCGGCGACACCTCCGTGCTCACCGAGAAGCTCGTCGTCACGTACGAGGAGATGGAAGTCGAGTGAAACGCGGCGGCACCGCTCAGGTCATGCAGACGGAGTTCGCGTTCGAGCTCCCGCGCGGCTACGTGGACTCGTCCGGAACTGTGCACCGTTCCGGCGTGATGCGCCTCGCGACCGCACGCGACGAGCTGGTCCCCCTGCGGGACGACCGGGTCCGCGAGAACTCGGCCTACCTGACGGTGGTCCTGCTGGGCAGGGTGGTCGTGCGGATCGGTGACGTGACGGACGTGCACGCCGGCGTCATCGAGAACCTCTTCGCCTCGGACCTGGCTTTCCTGCAGGACATGTACCGCCGGATCAACAGCGAGGGCCACACCCGGTCCGCGGTCGCGTGCCCGGGGTGTGGCCACGGCTTCGAGGTGGACATCGCGGGCGGGCGCCTGGGGGAACCGTGACGTACGCGCCGGACCGGCTGTACTCGGAGGTCGCGTACGTCGCCTACCACTTCCACTGGTCGCTCGACTCCATTCTGGACCTGGAACATCCCGACCGGCTGCGGTACGTCGCCGAGATCTCGTCGCTCGCAGGGAGGTGAGCCGCCCGTGTGGCCGTTCCGTCGATCCGTTGCCCTGCCCGTCGTCCGCGCCGACTGGCGGACGTTGCCGCCGTTGCAGCGGGTGGTGGGGGCGCATCCGCTGATCAACCCGGTGGGCGGGTTCTCGTCGCGGCTGGCGTCGTGGCAGAACCCGTCGTCGTTGGCGCCGCTTGGGCATGTGGTGAGTGCGGGGGCGCCTTCCGGGAGTGTTTCCGGGGTGGTGTCGGAGGCTGTGGGGGGTGCTGGGGTGTTTCCGGCTGCGCCGGTGGTGGCGCGGGCGGTGGAGGCGGGTGAGCCGTCGTCGGTGGGGTGAGCGAGCCGCCGGTGGGGGTGGTTGAGCCGTCTGCAGGGGTGGGTGAGCCGCTGGTGCGCGTGGTTGAGCCGTCGGTGGGGGTGGTCGGGCGGGTGGACGCGCCGGCTGAGCCCGCTGGCGCTCCGGTTGGCTCGGTTGAGCGGGTTGAACCGGTTGGTCCGGTTGAGGCGGATGGCTCGGTTGAGCCGGTGGTGGCGGTCGGTTCGGTGGATGAGCCCGTGGGTGGTGTGGCGGCTTCGCGGGCGGTTGTGCCGGAGGTGGGTGCGCCTGCTCGGCCGAGGAAGTTGGGGTTGGGCGAGCCGATCGTGCAGCGCGCGGTGGAGCCGGGGGCGTCTCGCGGCGCGGCTGAAGTGGGGCCGTCGGGTGCTGGGCCGGGTGATGCGGGGCTGGCGGATGTGGTGCTGCCGGGGGTGGGTGGCGCTGATGTGACGGGTGCTGTGGGCAGTGCCGGGTTGGTCGGTGGTGTGGCGTCTGCGGGTGGGGCTGGGGTGGTGCAGCGTTCGGCCGATGCGGAGGCGGGCGGTGTGCGGCCGGATGTGCAGCGCCTGCATGGCCAGCCGCAGGTTGGTCAACTACCCGTGGTCCAGCCGTCCGTGGTCCAGCCGCTGGCGGTCCAGCCGCCGGTTGTGCAGCGGTCGGTTGTGCAGCGGTCGGTTGTGCAGCGGTCGGTGGGGGATGGCGGAGACGGTGCTGGTGGAGACGGGGCTGGAGTAAACGGGCATGGCGGGGCCGAGGTTTGGCAGGCGGTGGAGTCCGCGGGGCCGGGAGGTCGGGGGTCGGGTGAGGTTCGGGGATCGGCGACGCAGCGGGTAGAGGTCCAGCGCGCGGTTGCTCGGGGTGGGGGAGACCAGGCGGTTGGCGTGCAGCGGATGAGCGCGCAGCCGGCGGATGCGCGGTCGGCTGGCGCAGGGTCGGCGGATGCAGGGTCGGTGGGCGCAGGGTCGGTGGGCGCGCGGTCATCGGGCGCGCAGGCGGTGGATGCGCAGGCCGCGGGTGCGTGGTCGTCGGGCGTGCAGGCGTCGGACATGCAGCAAGCGGGAGCACAGCCGATGGACACGCGGTCGGTGGACGCGCAACTGGTGGTTGCACGGTCGGTAGACACGGAACCGGGGGCAGCGCAGTCGATGGACGTGTGGTCGATGGGTGCGCAGCCGGTGGAAGCGCAGTCGATGAGTGCCCAACCGATGGATGCGCGGTCGCTGGAAGCACAGGCGGTGGATGCGCACTCGGTGAGCGGACGGACCGGGGACGGGTCGGTCGGGCGTGCGGGTGGCGGGCCTGTGGGCGTTCAACGGGTGGATGTGCAGCGGGTTGAGGCGGCGTGGACGGAGGATCGGCGGTGGGCGGACACCGGACCGGTGGAGGCGTCGCGGGTGGCGGGGCAGATGCCAGGTGTGCAAGGGCTGGGAGTCCAGCGAGTCGAGGGACACCGGGCGGAAGTCCGGCGCGCGGAGGGGCACCAGCCGACAGAACACCAGCCGACAGAACACCAGCCGGCTGAAGTTCAGCGCTCAGAAGACCAAGGCGCAGAGGCCCGCGAAGCGGGCTTCCAGCGAGCAGAGACCCAGGTGGCAGGCCAGCGAGTAGAAGTCCAGGGCGCGGAACAGCGCTTGGAAGTACGACCGGTGCAGAGGCAGCGGGACGAAGTTGCCGGGGCTCGCGGTCTGCAGGCAGAAGCGTCGCGGACTGATGGTCGGTGGGCCGACGTTCAACGGGTGGAGAGCACAGCGTCTGGGTCGCCTGTGGGGGTTCGGCTGCCGGAGGTGCGACAGGCGCAAGCCCGGCAGGCGGCGGTCGAGGTGCAGCGGGTGGTCGAGGTCGGGCCCGTGGACGTCCGGCACCCGGAGTTGCAGCGGCTCACGGTTCAGCAGGTGGAGACGAACCCCGCGCAACCACGGCAACCAGACGGGCAGCACGTCGGTGAGACCGGGTGGCCACACACCACGAGAGAACCCGTGCGACCGGCCGTGCAGCGTGCGGAAGCCGCTCAAAGCGTTGCACCACAACAGAGGCGGGAGGTGGCGCAGTTCGACCCACCCGAGCCCGCGAAAGCCCCACCGCTGGTCATCGCGAGAACCACCGAACCCGGACCCGGAACAGAACCCGGACCGGCACCCCAACCAGCGCAACAGGAACAACGCGTCGAGGCACCCAAACCCGAGCAGAGCCCCGAGGAGTTGCTGACCAAGTTGTACGACCCGCTCGTGAGGCGGTTGAAGGCGGAGCTGTGGCTGGACCGTGAGCGTCGAGGCGCGCTCACCGACCTTTAAGGACGTGCGATGACCGCGCCGGAGGAAGCCGTTGCCGTGTGCTTCAACGTGCAGGTGGACAAGGACGACCTGGGGTCGTTCAACAGCTGTGAGGGGTTGGGGTGCGAGTTCGTGATCGAGCAGCGGGAGGAGGGCGGCAACAACGGGATGGTGTGGCAGTTGCCCACGCGGATCAAGTACCCCAACGTGAAGCTCTCCAGGCCGGTCACCAGGGACAGCCAGAAGATCACCCGGTGGATCGCGGGGATGGCGGCCGGGGTCAAACGCCGCACCGCCGTCATCGAGGCCAAGAACCTCGAAGGCAAGACGATCGCGAGCTGGTCGCTGGCCGAGGTCATCCCCGTCAGGTGGACGGGGCCGCAGCTCAGTGCGGAGCAGGCGAAAGTGGCCACGGAGACGCTTGAGCTGGCGCACCACGGGTTCTTGGACGCGCGATGACCGTCACGTTCACGTCGGCCGGGTCGGCGACCACGTCGAAGAAGATGGAGCACGCGAGCATCACCGTGCACGAGCCGCCGAAGCCGGGCGGGTTGCAGCAGCCGGGGACCAAGCTGAGCGAGATCAAGTTCCAGTTCAACCCCAAGGAGCTCACGCTCGCCAAGAACGCCAAGTGGCAGCGGCAGACGCAGCCCAACGCGGCCAAGAGCGGGGTGCCGGAGTTCAAGGGGGCCGAGCCCGCCAAGCTGCAGCTGGAGATCTTCCTCGACTCCACCGACACCATGGGCGACGCGACCATCAAGCTGGTCGAGGAGCTGTTCAACCTCACCGTGCCCACGAAGGACAGCCGCACCAACGGCAAGGGCTCGCCGCCGTGGGTCATCTTCAAGTGGGGGACCACGACCGGTTTCCCGAGCTTCGTGTCCAGCGTCAGCGCCAAGTACACGCTCTTCACGCCCGGCGGGATGCCGGTCAGGGCGGTGTGCACGGTCAGCCTCGAAGAGGTCTCCGGCGAGCCGGGCGGGCAGAACCCGACCAGTGGCGCCAAGGAGGCCAGGGGTGCGCACGTGCTCACGGCCGGGGACAGCCTGCAGTCGCTGGCGTACCGGGCGTACGGCAACCCCGAGCTGTGGCGGCACATCGCGGAGGCCAACGGGATCGACGACCCCATGCGGCTGCGGCTCGGCAGCACCCTGCTGGTGCCGGCGTTGGAGGAGATCGATGGCTAACGAGAGCTTCGCCAACAACCTGGTCGTCGAGGTCGACGGCCAGGCGTTGCCCGCGGACGTCAAGCTGCTGCTCACCTACGCCTACGTCGACGACAGCCGCAACCTGCCGGACATGTTCGTGCTGCGGTTCCGCGACCCCGGCCACGTCGTGCTGAACAAGGGTGGGTTCAAGATCGGCGCCAGGACCGCGCTCAAGGTGCAGACCGCCGACCCCGGTGGGCCGAAGCCGTTGATGAGCGGGGAGATCACGGCGGTCGGCGTCGAGCTCGACGGGCAGGGCACGTTCACCGAGGTGCGCGGGTACGACGAGGCGCACCGGCTGTTCCGCGGCACCAGGGTCGCGGTCTACCCGAACATGACCGTCGCCGACGTGGTCAGGAAGGTCGCCCAACGGGCCAAGCTGAAGACCGGCACCATCGACGACGTCAAGGGGTTCGGCGGCAGGCCGGACACCCAGCTGAGCCAGGACAACGTCAGCGACTGGGAGTTCCTCAGCCGGCTCGCGAAGGCGGTCGGCGCGCAGATCGCGGTCAAGGACGGCAAGCTCGACTTCCGGCTGCCGGAACCGCCCACTGCCGCACCGAAACCGAACGCGAAGGCGAAGACCAACCCGCTCGTTCTTGAGCTGCACAGCACGCTCGTGGCGTTGCGGGCCGGCCTCACCACCGCGGGCCAGGTGCCGGAGGTGCAGGTCAGGGGCTGGGACTTCGAGAACAAGCAGGAGATCGTCGCCACCGCTGTCCCGACCACCGCGGGCGTCGAGGTGCCGCAGGCCAACCCGGCCGAGCTCGCGAAGAAGTTCGGCGCGCCACCACACCTCGAAGCCGGCCTGCCCTACCGCACGCACGCCGAGGCCAAGACCGCCGCGGACGCGCTCGCCGCCCAGCTCGGCGGTTCCTGCGCGGAGCTCACCGGTGTGGCCAGGGGCAACCCGAACCTCAAGGCGGGCACGGCGGTCGCGCTGACCAACGTCGGCGAGCCGTTCCAGGGCCGCTACACGCTCACCAGCACCCGGCACCTCTTCGCCGAGCACACCGGCTACACCACCGAGTTCACCGTCTCCGGCCGCCAGGAGCGCTCGCTCTACGGCCTCACCCACGGCACCAAGGCCAAGCTCCTCAACGGACTCGTGCCCGCCGTGGTCACCAACGCCAAGGACCCGTTGAACCTCGGCCGCGTGCAGCTCAAGTTCCCCTGGCTCTCCGCGGACTTCACCAGCGTCTGGGCGAGAACCGTGCAGGCGGGCGCCGGAGCCGGCCGCGGCATGCTCGTCCTGCCCGAGGTCGGCGACGAGGTGCTGGTCGGGTTCGAGCACGGCGACCTCGACGCGCCGTACGTGCTCGGCGGCCTGCACAACGGCAAGGACAGACCGCCCGAGCTCGGCAAGCCACCGGTCGACGGCGGCAACGGGGAGATCGCGGTCAGGGGGTTCGTCAGCCGCAAGGGCCACAAGGTCGAGCTCGTCGAGGACGAGGGCATCGTGATCTCCAGCGGTGACGGGAAGTTCGTCGTCAAGCTCGACCAGAAGGCGCAGACGGTCGAGATCACCAGCGGCGGGAAGGTGACCGTCGGGGCGCGCAACGGCATCACCGTCGACGCGGGCACCGGGCCGCTGGAGCTCAAGGGCCGGAACGTCGCGATCAAGGCCGCCGCCGAGCTCAAGGCCGAGGGTGTGCAGGTCAAGGTCGCGGGCCAGGCCCAGACCGAGGTCACGGCCGACGGTGTCCTCACCGTCAAGGGCTCGATCGTCAAGATCAACTGAGCAGGAAACGAAGGGGGAACCGGTGCCACCGGCAGCCAGAGTGAGCGACCTGACCGGGCATCCGGGCGTCATCATGCCGCCCGGCGTCCCGACCGTGCTCATCGGTGGCCTGCCCGCCGCGACGGTCGGCTCGATGCACACCTGCTCGTTCCCGCCACCCGCCGTGCACCCGCCGACGCCGATCGTCCCGCCCGGCTGCCCGACCGTGCTGATCGGCGGCAGACCGGCGGCCCGCGTCGGCGACCTGAGCGGCTGTGGCGCACCGGTCCTGCCACCCGGCTGCCCGACCGTCCTCATTGGAGGGTAGATGGACTTCATCGGCAGGGGCCTCAGCTTCCCCGTCCGCACCGACGCCACCGGCAGCGTGGCGCTCGTCGACGGCGACCGCGAGGTCGTCGAGAGCATCCGGCTGATCCTCGCCACCGCGCCGGGAGAACGCCCGATGCGCCCCGAGTTCGGCTGCGCGATCCACGACCTGGTGTTCGCGCCGGCCGACTCCTCGACGGCCGGCCAGATCGCCTACGAGGTGCGGCAGTCGCTGGAGCGCTGGGAACCGCGCATCGACCTCACCGACGTGGTCGTCGACTTCGCCGAGGCCGACAACGGCACCCTGCTGATCGACATCCGCTACACCCTGCGCACCACCAACGACCCGCGCAACCTCGTCTTCCCCTTCTACGTGATCGGGCCGCACGAGCTCGACGAGGACGGTGCGTGATGCCGCTGCCTCTGCCGAACCTGGACGACCGGCGTTTCCAGCAGCTGGTCGACGAGGCCAAGCGCCGCGTCCAGCTGCACTGTCCGGAGTGGACCGACCACAACGTCTCCGACCCCGGCGTCACGCTGATCGAGGCCTTCGCGCACATGGTCGACGAGCTGGTGTACCGGCTCAACCGCGTGCCGCAGCTGCACTACCTCAAGTTCCTCGACCTCATCGGCGTCGAGCTGTTCGCCCCGACCGCGGCCCGCGTGGACGTCACCTACTGGCTCTCCGCCCCGCAGGCCGCCCCCGTGGTCGTGCCGAGCGGCAACCAGGTCGCCACCCAGCGCCGCGGCCACGACGAACCGGTCGTCTTCACCGTCGACCGCGAGCTCACCATCGTGCCGTGCGAGCTCGCCCACCTCGCCACCGAACCGGCGGGCGGCCAGCCGGCGTTGCGCACCGACGACCTCAAGGCCGCCAAGGAACCACCTGTGTTCGCCGAGCAGCCACAACCGGGCGACGCCGTGCTGTTCGGCCTGTCCGCCGCGGTTCCCGGCTGCGCGGTGCTGCTGCGGTTCGACTGCACGCCGATGGGCTCCGGCATCAACCCGGACGACCCGCCGTGGGCGTGGGAGGCCTGGACCGGCGACGGCTGGGCCGCCTGCGAGGTCGACCGCTTCGACAACAAGGGCTTCAACGCCGCCGGTGACGTCGTCGTGCACGTCCCGCCCGGCCACACCACCTCGGTGCTGGCCAGGCAGCGCGCGGGCTGGCTGCGGTGCCGCGCCGAGCGCCTCTGGCCGGACCAGCCGTTCTACCAGCGCTCACCGCGGATCAGCGACGTCACCGCGGCCACGATCGGCGGCACCACCGAGGCCGTGCACGCCGACGTCGTGCACAACGAGACCGTCGGCGTTTCGGAAGGGGTTGCGGGCCAACGGTTCCCGCTCGCCAGAACGCCCGTCGTCGCGGGCGCCCCGATCACCGTGGAGGTCGCGACCACCGACGGCTGGGAGGAGTGGACCGAGGTCCCCGCGTTCGCCGAGTCCGGCCCGCGGGACCGGCACTTCCTGGTCGACAACGTGGAGGGCACGCTGATCTTCGGTCCCGCCGTGCGCGAGCAGGACGGCACGCTCCGGCACTACGGCGCGGTCCCGTCGAAGTCCGCTGCCATCCGCGTTCCCGAGTACCGCACCGGCGGTGGCCTGCGCGGCAACGTGGCCCGCAACCTCGTGACCGTGCAACGCGACCCGGTGCCGTTCGTCAGCACCATCACCAACCGCAAGCCCGGCCGCGGCGGCGTGGCCGGCGAGTCGGTCGAGGACGCGGCCCTGAGAGGCCCGCTGTCGCTGCGGACCAGGGACCGGGCCGTCACGGCCGAGGACTACGAGATCCTCGCGCGAGAGGCCGCTCCGGAGGTCGCCAGGGTGCGGTGCGCGCCGGGTGACGACGGCGTGCGCGTGCTGGTCGTCCCCGCGGTCCCCGAGCACGAGGAACCGGACTTCGCCGCGTTCCAGGTCGACCAGGAGACCCTCGAACGGATCGCCCGCCACCTCGACGCGCGCCGCTGCGTCGGGGCCCGCGTGAGCGTCGAACCGCCCTTCTACCAGGGCATCACGGTCGTCGCGGACCTCAGGGCACGTGCCGGGACGCCCACCGAGGCCGTCCGCGCCCGAGCGGTGGACGCACTGGCCGCCCACCTCGACCCGATCACCGGCGGCGCCGGCGGCACCGGCTGGCCGTTCGGCCGCCCGGTGCACTCCGGCGAGGTCTACGCGGTCCTGCAACGCGTCCAGGGCGTCGAGCTGGTCGAGGACGTCCGGCTGTTCGCGGCCAACCTGCTCAGCGGCGAACGCGGCCAGGCCGTGCAGCGCGTCGACCTGCCGCCGAACGGGCTCGCGTTCTCCTACGGCCACCAGGTCCGGGTGGTGAGGAGCTGA

Protein sequences of DBSCAN-SWA_2

>NZ_CP016793|5038097:5093795|5071877_5073842_+|WP_065917197.1|DBSCAN-SWA
MIFERLAALERRIRAAVASRRATDPSPDDPFRGLYLSDEVIDALLDSARDPFAGYVDVPADGRLGRLASVACLSDVDVELLLVALAPDVDSRFEQFYGYLNDDVTRRRATAGLALRLCGLAEASSTGRSRLDRGSPLVRSGMVVVEDLDRPLLSRSLRVPDRVVAHLLGDDRPDPLLADFVTLPGEPVPLPGAERLARGIDRGVRLVYLREHPGGGAAELAVAALAQAGFPALLVDSARMTDAVAVVREALLRGAGVVVGSVDPSFSLDPLLHDSVPLVAFGSGAWEPRWTRVPPLQHEALQVPFDVRASLWRTSLEGRLAAGVDPAEVTAHFVLGPTQISRAASAAAVSALAEDGAVDVRHLRAGARSQNAGGLQRLARRIEPAVSWRDLVLPVPVTSLLQELAARARHRDRVIDEWRMRPGGGRGRGVTALFAGDSGTGKTMSAEVIAASLGLDLYTVNLATVVDKYVGETEKNLERIFVEAAGVNGVLLFDEADAIFGKRSEVRDAHDRYANIESAYLLQRMETFDGIAVLATNLRANLDDAFTRRLDVIVDFPLPDVPLRRNLWDRCLGDAVPRSSDVDLDFLAGSFELAGGHIRSAAVTAAYLAAAGDHVVGMVELIGAVAREYRKLGRLVGEREFGRYLDFATERLVG
>NZ_CP016793|5038097:5093795|5051747_5052335_+|WP_065917177.1|DBSCAN-SWA
MAYDEGLAHRLGDALAALPGIGTKKALDRLRAALDGYGPLREVTEPGGLGFEWDGDLLARVVGDEVLVRSVAGWTVATGDLRAAVNGAARVVLDECVARWHEQLASADPAGSTRAMLALTHHEPDRAALQRLLLDHVRHPDRNLRQLAVTCLGHVGRLDRQVLPEVVERLNALLDDPELGGTADDALGDIESFRR
>NZ_CP016793|5038097:5093795|5040521_5041322_-|WP_065917171.1|DBSCAN-SWA
MVDRVSWVPEGVNVDVPSSARIYDYLLGGGHNFEADRETAEALIKVLPVRDMARRNRAYLRRVVLELAGLGIRQFLDLGSGIPTVGNVHEVAHEVDPGAKVVYVDFEPVAITHAELMLAGEPNVTALLADLREPEKVVQQARELLDFSQPVGLLVVGVLQFIPDSDDPWGVLSRYVEALAPGSYLALSHFTADSMPAAMAAGKEIFAKTAEPITPRTKAQVTDMLQGTEIVEPGIVFTPQWRPETPEDVGTDPSKANLYAAVGRKP
>NZ_CP016793|5038097:5093795|5058608_5059679_-|WP_065917183.1|DBSCAN-SWA
MKDDYTVGVEQEFLLVDPRSRRPVALAPRVGELSRAPGDLDVQGELTPFQIEVATGVCHTSAELDAQVRAARRVLVEAADEAGCRLVATGMPPIGKAGPPPGSDDPRYHRIEHSHRRLVIGQGACGLHVHVGVPSKAAALEASNKLRAWLPTLLALSANSPYQDGEETGYASWRSMVWSRWPVSGPPPRWDGPEHYDRTVEALIATEALIDRAMVYWDVRPSADHPTVEVRVADIPLLATEVVVLAELVRALVASEPPEQRVDDSVLRAAYWRASRDGIDGLAADPSTGKLLPAFDRAVALVEHVAPALRERGTLSTVERQIDWLRHNGCGAARQRRCQDPESLVDMLIARTREET
>NZ_CP016793|5038097:5093795|5056290_5056719_+|WP_083268865.1|DBSCAN-SWA
MLAVAVEEARTGLAEGGIPIGAALFDGDGRLLGRGHNRRVQDGDASMHAETSAFRDAGRQRGYRGTTMVTTLSPCWYCSGLVRQFGISNVLIGEATTFHGGHDWLAEHGVGITVVEDPACIEMMTRFIAEQPELWFEDIGQD
>NZ_CP016793|5038097:5093795|5060638_5061064_-|WP_065917185.1|DBSCAN-SWA
MKRLRWPQKLAIGTGALLALWGVAGFLVTGFSGFAAEADTWLLGLRVNPLQNVLHLVFGAALLLSFRNLKALGNTALLVAAALLVTFGLGMARYDEQVVNVLNVNFGSNALHFLAGFAALAAAQGAVWCRQCDRAQVLRTP
>NZ_CP016793|5038097:5093795|5041846_5042476_-|WP_065917173.1|DBSCAN-SWA
MTSASPIAALVSAAAEGDQGAWNEIVDRYTPLVVSVIYKHRLRPADASDVNQTLWLRLVEQIGRLREPEALPGWIMTTTRNECLRVLRVQQRTHLYDPLTESDVLESAEDSDADADLLAVERRQALRDGFAELTEQCKRLLTKLMTDPPPSYQVVSEELAMPVGSIGPTRIRCLEKLRKTSAISAFLGSPAQRKPQVRGGVLGAARLGQ
>NZ_CP016793|5038097:5093795|5041422_5041869_-|WP_065917172.1|DBSCAN-SWA
MRHDWDSDEVLLDALRDALSTPPSSDVPPEFVEAAKAAFTWRTVDAELLLITSYDSVLDDTLFARARSTSTARQLVFDADGVTLQVEVSAAGVTGQLMPAAGDVTLVAPAGDVETAPVDELGMFVMGPGPRGPVKFRFAGGSTDWFIL
>NZ_CP016793|5038097:5093795|5057841_5058609_-|WP_154697479.1|DBSCAN-SWA
MRLPAPRGHMSAALVAALRSAPVPRPALLVSGGTREPGLDDDLQISLWTCYRLRTRGFDDAHPAWDDHPALAQFLSALEARWERGLRSLRETTPAVVLDGTGAAELRKHHAFWHPRREMRSALRDIHGDAYGSRDERTHSVLFTVTLRDLDCGTGVDEMPAPTLALANALSLFGLHQRLVGALVGFLTAVDTIGGDPFAQLLPVQCPPDDVRLGFTACHELHARLVQHVHAACESGRSSLRGRWLLPHARVNVGC
>NZ_CP016793|5038097:5093795|5085497_5085641_+|WP_170067961.1|DBSCAN-SWA
MTYAPDRLYSEVAYVAYHFHWSLDSILDLEHPDRLRYVAEISSLAGR
>NZ_CP016793|5038097:5093795|5091869_5093795_+|WP_065921334.1|plate|DBSCAN-SWA
MPLPLPNLDDRRFQQLVDEAKRRVQLHCPEWTDHNVSDPGVTLIEAFAHMVDELVYRLNRVPQLHYLKFLDLIGVELFAPTAARVDVTYWLSAPQAAPVVVPSGNQVATQRRGHDEPVVFTVDRELTIVPCELAHLATEPAGGQPALRTDDLKAAKEPPVFAEQPQPGDAVLFGLSAAVPGCAVLLRFDCTPMGSGINPDDPPWAWEAWTGDGWAACEVDRFDNKGFNAAGDVVVHVPPGHTTSVLARQRAGWLRCRAERLWPDQPFYQRSPRISDVTAATIGGTTEAVHADVVHNETVGVSEGVAGQRFPLARTPVVAGAPITVEVATTDGWEEWTEVPAFAESGPRDRHFLVDNVEGTLIFGPAVREQDGTLRHYGAVPSKSAAIRVPEYRTGGGLRGNVARNLVTVQRDPVPFVSTITNRKPGRGGVAGESVEDAALRGPLSLRTRDRAVTAEDYEILAREAAPEVARVRCAPGDDGVRVLVVPAVPEHEEPDFAAFQVDQETLERIARHLDARRCVGARVSVEPPFYQGITVVADLRARAGTPTEAVRARAVDALAAHLDPITGGAGGTGWPFGRPVHSGEVYAVLQRVQGVELVEDVRLFAANLLSGERGQAVQRVDLPPNGLAFSYGHQVRVVRS
>NZ_CP016793|5038097:5093795|5061838_5062306_-|WP_065917187.1|DBSCAN-SWA
MTTTIEKSVDVHVPVSTAYNQWTQFESFPAFMDGVEKIDQITPTRTHWTTKIGGVVREFDAEITEQHPDERVAWTAVEGTPQAGVVTFHRIDNETTRVHVQMEYDPETFIEKAGAALGVVGQRVEGDLKRFKEFIENRGVETGAWRGDVTPPPQV
>NZ_CP016793|5038097:5093795|5038097_5038613_+|WP_065917169.1|protease|DBSCAN-SWA
MFLRKTIAVVASAAALSVGLVGTAEAAPRTLTYNSSGAGEFQAAVDRGAQVWNNSVVNVRLVKVTGAANITVTVDNQWPRAYVTSLGRGRWVMGRQAVNEGHDTTRISSHEFGHLLGLPDRRTGLCTDLMSGASAGTSCKNPNPNTREKAEVEANFRTAVTVGPSTYVDAA
>NZ_CP016793|5038097:5093795|5057458_5057821_-|WP_170067960.1|DBSCAN-SWA
MPDPTTLATVVVDRISSDVVVLHVSGELDTTSSSELTAPLDTHVVEANRAVVVDLGGVRFLGSAGLEALVLGQQRAGRNNVEFVLVASSRAALRPIEATGLDTVFTILGSVDEAVDRYSA
>NZ_CP016793|5038097:5093795|5052338_5053826_-|WP_065917178.1|DBSCAN-SWA
MASTQIGVSRPPLDLDDLPAPEEVFKVRKLGPRQIVQFVIGPSLIALGISIGSGEWLLGPQAVGKFGFVGVGWVITVSALLQTFYNVEIARYVVATGEVPVVGWGRVPPGWKFWVPVSLLVFYFAFLFGGWAAGAGQGLFALIAGRGYRPDEIEYVRLLAIGLLFVVFLITAGARKVSRALELTNWVLVGSLLLVLVVVTVAIVPFSVWSEGVRGLVTPAAPPEGITASQLGGLAGFTALASGLNWYAMNHYRDKGYGMGHRVGFISGLRGGKQELRPVGVTFVDTPANASLWRRWYRLLLIDQWAVFFVGAMLGMLLPTVLMAHLVAVSGTQPTAANVPTFSAEQLGLLYGQGMFYLMLVVGVLVLFSTQLGIFEALVRNFTDAMHAVSPKLRRRIEDDPRRFYYPFMLFVLVLIAGAMHLALPVELVQISANMSNLGALMFPFALMYLNSRLPRPARPRWWHHVVLVLNVVFFGFFFVNFVFELVTGGPLVRF
>NZ_CP016793|5038097:5093795|5046408_5049783_-|WP_065917175.1|DBSCAN-SWA
MHNEVNSPVHGVVFQSRDIYGAVNVGAVEPEYPPLTSWRDRPELTRELEELLKVQRDTAVTLPHHLQLLKKQPRLIDVYVQRSVLPQRHEEPEPDPEQGDSKAVDREPKHSDSVMSLREALATGRHLLITGGPGSGKSTLGHMYVQVLADEWLEPSGNPPLAEPLMPLRVSAKALIGEESWSELLAKAVRSNKLNAPPRPELFARPALGARWLVFVDGLDEIVEPDHLRQVIDALTSRIRHGSEHQLVITSRDLASGVLDQLQVAHLDRYRIEPFGVDQLEQFAQAWFQIQDPTRVAERKREFLRQVMDGRLRELVTVPLFATIAAIANTLEPERELPQNRVDLCERFLTYLLDEKLNQRTTITELRRTIDDPERLELVEWIYANRAELIEHLAVERLDSELPLAEIATEWIKHPSPPEDLEAVLTSIGVFAQTGEGIDFLHRLFAEYLAARAEAPRIPADFPQLDMWVERGTNEAKETFVLFTFVLWSRVEGNDIGLVVERLLNRGRKHVLLGAKLFAENVDVPAEQAAHLVDRLVDLILTINPGSDPWSEVNDVCRAVRGLTSTVIADGLTARLRELQQNPELLLTIRICCAVALEQLEAGAGMMQWLEKQFFASSDPAVRRAVALGLAEILPDGANRAEQLVVQDTDEADKSDYARIVANVRLLLDLKRPDPAARLLRRMVKHVRQESSATPGSSHLPRQVSNLGDQELISWFRLLRLATDARCTDEALLAADMILARQDAESHELRAAVMTLMSHGGATAVDRIVEQVQDRSAEHKLAAATTLFGDHQDAAAELARGVAVDPDTTDYAKVTACVLIAEVDPMSTSALLDGVDDVSADLTAPLAALVLQGVPSAKDLFRKFLARKVTEWDFSYIAESALELDGFSRDVHVVTVGGSEERWAEVAPLLYRAGHHELGEDLVERLIGQRAPDPAALASCADSLLSQQMPEQAKPLLEKLMTLVGSGTADNARLVAPILQEYGRTEEAVTVAEQALLRELADGGLYVEECVGILLDIAGSKRADFIAEQVANHAMSMDRRLAVAGEFRQRGLFAHMAATWLDVLRHHAFEIKEGVETANKLVKCGYRQQAIEVVREVLDKDELTPSQRPTVRALLAWLEAMGAE
>NZ_CP016793|5038097:5093795|5042541_5043741_-|WP_065921331.1|DBSCAN-SWA
MSKSPERSELYERAFQQLIAEDKNISFHAERGREFLYRPGQLLVAQADLDRVIAKLRENNVEARPADGFGGMARLILPNNLEDIPRIVRLLRDQRNWPNERVPLVQPHHVVVGHGGNVMGNPGDRPRPTDPFNPPKADDRLSGIRVGVLDTGISSGAQLEHPDWFKDRFFKEPDDVDPAYTSGALFGLQGGHGTFVAGVIQSAACGVAFDPEVALDVNGFGDEERLVAKIAEMGKKRLDLLNLSLGCYTEDDVASEPLRNAINALPPETVVVASAGNRGDQRPSWPAAFCRVTAVAALAQNSDGLIIPACYSSFGHWVDACAIGNRSSTYLKGEWKLPGEPGATPFALWAYWSGTSFAAPWVTGRIAATMAKDGLTAVQARDKLLVNPEFHAGYGVFVK
>NZ_CP016793|5038097:5093795|5087465_5087945_-|WP_065917207.1|DBSCAN-SWA
MSGFRTLHGRSHGFSRGVWPPGLTDVLPVWLPWLRGVRLHLLNREPLQLRVPDVHGPDLDHPLHLDRRLPGLRLSHLRQPNPHRRPRRCALHPLNVGPPTISPRRFCLQTASPGNFVPLPLHRSYFQALFRALDFYSLACHLGLCSLEARFAGLCALVF
>NZ_CP016793|5038097:5093795|5091174_5091459_+|WP_065917212.1|DBSCAN-SWA
MPPAARVSDLTGHPGVIMPPGVPTVLIGGLPAATVGSMHTCSFPPPAVHPPTPIVPPGCPTVLIGGRPAARVGDLSGCGAPVLPPGCPTVLIGG
>NZ_CP016793|5038097:5093795|5064061_5065921_+|WP_065917190.1|DBSCAN-SWA
MTTATSATTTTTVVTRVRDRAERTPEKIALRAKDLGIWQEVSWAGYWANVELVGHALLALGLRPGDRVAIHSENRREWLYADLGTVAARGVTVGLYPTNPASEVAYLLSHSGARILIAEDQEQVDKALLVLEDTPDLEWIVYLEPRGIRGRYDNPKLLAWEDFLALGAAHRDEFGGELAERMAATGPDDVMTLIYTSGTTGPPKGAMLTVANVEFAVHVLVEGGGFTSPPPSSADVTLSYLPLCHVAERIFTTWFSAASGVQVHFAESIETVQANLREVQPTILFGVPRIWEKVLAGVTIGVSSASWLKRAVTRFWLRRAEGIGDTLVRTGGKHTGSSRLLYALGWLFCFRALKARIGMRYVRYAASGAAPIAPDVLKFFMGIGVPMHEVYGMTENTAVATGNRPGRVKVGTVGEPQPGIELRIDAETGEILTRHGGTFAGYWRDPDSTARVLTDGWLHTGDVGEWVGGTHVKITDRMKDIIITAGGKNIAPSELENALKTSPYVKEAVVIGDQRAYLVALIGIEYETVGHWAQQRKITYTTYRDLSEKPEVLELVQKIVTEVNGKFAQVEQIKKFRMLPKELDHEDGELTATQKVKRSALGKTFGELVESMYGGASRG
>NZ_CP016793|5038097:5093795|5085132_5085501_+|WP_154697481.1|DBSCAN-SWA
MQTEFAFELPRGYVDSSGTVHRSGVMRLATARDELVPLRDDRVRENSAYLTVVLLGRVVVRIGDVTDVHAGVIENLFASDLAFLQDMYRRINSEGHTRSAVACPGCGHGFEVDIAGGRLGEP
>NZ_CP016793|5038097:5093795|5062524_5063298_+|WP_065917188.1|DBSCAN-SWA
MLEANNLEVVYDDVMLVLRGVSLRVPKNQIVALLGANGAGKTTLMRAFSGLLDVHDGKITKGTITLDGEPIHKLSPARIAERGVKQALEGRRILAELTVEENLKVGGHARPKRLKSNLDRCYELFPRLLERRRQSAGYLSGGEQQMLSIGRALMSEPEYLLLDEPSLGLAPLLVQQIRDLVVKIKEQGTTVLLVEQNASMALSIADHGYVLETGKVVMDKPAQALLADDDIREFYLGLGTSSFRAVKHYKRRKRWLS
>NZ_CP016793|5038097:5093795|5080228_5081440_-|WP_065917202.1|DBSCAN-SWA
MYLSTVDRPKTANWKGLSGNVFALGTVSLITDVSSEMVAAILPLYLVIGLQLSPAAYGLVDGVYTGATTLLRLAGGYLADRTNRRKAVAGFGYGLSAVAKLGLLAVGNSTAALGLVITADRAGKGLRTAPRDALITLSTPSGDLGRAFGVHRAMDGIGAFAGPLVAMAVLAASAQSFDAVFVTSFCIAAFGVLVLVLYVRDRPKPLQRKEPLKLALLKDPAVRRIVAAAALLGLVTIGDGFVYLLLQKREGLAFGWFPLLAVGTSLVYLLLAAPLGALADRVGRLKVMLCGYGALTAVYLLLHGPIGGVPLMVTVVVLYGVFYAATDGVLMALAGPVLPERLRTTGIALIQSGQALAYLGSSVLFGLAWQFLGPEIATRTAAVAVVIALVATAVLLGGRKVRA
>NZ_CP016793|5038097:5093795|5091459_5091870_+|WP_065917213.1|DBSCAN-SWA
MDFIGRGLSFPVRTDATGSVALVDGDREVVESIRLILATAPGERPMRPEFGCAIHDLVFAPADSSTAGQIAYEVRQSLERWEPRIDLTDVVVDFAEADNGTLLIDIRYTLRTTNDPRNLVFPFYVIGPHELDEDGA
>NZ_CP016793|5038097:5093795|5059728_5060652_+|WP_065917184.1|DBSCAN-SWA
MRLRRSNTAGPGWTRRRHGKGFRYATTAGEPLGPEEVARVKALVIPPAWRDVWISPHPNGHIQAIGVDDAGRRQYLYHEQWRMNRDAEKFDRVLLLAPRLPKFRAQIVADMRTRGRLRLLAIALRMLDLGVFRVGHEEYAEENGSHGVATLLCEHLQVRGDRVRFQFPAKHGVQVDEEITDPQLARAVRTLLKDRTPDCRVFDMTAYDVNERFRELVGDQFTVKDLRTWHATVAAAKAFAEVLRERGKPTKRAVSAVMKDVAEHLGNTPAVARKSYVDPRLVEAFENGKVIGGGDPERAVLRLLRVS
>NZ_CP016793|5038097:5093795|5074341_5075100_+|WP_065917199.1|DBSCAN-SWA
MEVARPQREREIIMALIDGAVAVHGVASGVVASSRLADAVSRLRTSPPASRPRRGGEPRTISGGSRRERELRTGHRPANDNALDDEVAAATGTRGGGRTTASGTPHEVRPAGADRPHNAHHTSTRGSTRHDHQVGMARSQADQQAAAERAAAALARAQARRMGGRVNEVLNRVRNLPSAAIETLRNIPGKWARLDEVARMLQAERRGYNLNAALLGESRVPSQFTNEQRRVLEEALTDLADLLDHHIHLIGR
>NZ_CP016793|5038097:5093795|5068200_5069301_+|WP_065917193.1|DBSCAN-SWA
MKGRPELYTSYGQDMAFLNTRPKRAWSGGLVVFALVVPFLITDDLLQLLATGFVAAIGAIGLNIVTGYAGQVSLGHAFFLAIGAYTGAALSGSETGRVIGFGITSLPIWLLASGLVAALFGVLVAPVAVRLRGLYLAIVTLGLVFLGEHVFREWTSLTGGPGVGRPAAVPELFGVRLDRDSAFFTAAQQLYLVMFVLLVIFAVLARNLVRSRVGRAFAAVRDRDLAASVIGVDLTKYKVLAFAVSSFYAGVAGALLFVVNGFFDPGSFNLLLSVQYIAMVLIGGAGTISGAIMGALFITLLPRITRELPTVLPFISGDATGAITVFQVEAVLYGVLIIVFLIVEPRGLFGIWVRVRNYWRTWPFSY
>NZ_CP016793|5038097:5093795|5053937_5056262_+|WP_065917179.1|DBSCAN-SWA
MRRTLAGAAALALMTAGLAIPAAATPAEQPETQVRQQSDEQPHELELKRRALKQQALAEVLTGEVTAEKRGTSTVAKVGKKQARDQYVELKREKTDKIFVILAEFGNERHPDYPDRDTDPNTPGPLRFDGPVRNQIPAPDRAVDNTTIWRPDFSRQYFQDLYFSRAKDANSVANFYDKQSSGRYTVDGLVTDWVKVRYNEARYGRSNGYPCGDNICNNSRELIKDAVTQWVDDQRAAGKTTEQITAALREYDVWDRYDYDFDGDFNEPDGYIDHFQIVHAGGDQADGDPWQGEDALWSHRGYAFKNYNTGPGTNKLGGAPIGDTGLWVGDYTVQPENGGVGVFAHEFGHDLGLPDHYDTNGGTNGVNWWSIMGQNRVNAPGEATGERANEFSAWDKLQLGWLDYEIAVAGQERTFQLGPHEYNTAKAQGLVVVLPDISKSFDYGAPFAGGKMWWSEKGNDLDHSMTAPLDLRGKTTASLSLKARYDIEADYDYLYVEASNEDGSWTQLDGTANGAPFVRDSGDAPAISGSSGGQWVDVTVPLDAYAGKNTKLRLAYRTDGALAPQGFFADEITVVADGTPVLTDGGETAGTWTTRGFRTTEGKETKAFDQFYIASNRTYESYGQYNRTGPYRYSFQDKPDLVEHFPYQDGLLVSLWNTSYLDNNVSEHPGEGLILPIDANPAPLYNLEGQRWSPTIGGYDAPFSLQKSDSFTLHVNGKASYVRGAAAQPVFDDTKQYWFAEQPNAGVKLPAVGVGLRVTKQSGTSMTVKLFKTK
>NZ_CP016793|5038097:5093795|5088233_5088662_+|WP_065917209.1|tail|DBSCAN-SWA
MTAPEEAVAVCFNVQVDKDDLGSFNSCEGLGCEFVIEQREEGGNNGMVWQLPTRIKYPNVKLSRPVTRDSQKITRWIAGMAAGVKRRTAVIEAKNLEGKTIASWSLAEVIPVRWTGPQLSAEQAKVATETLELAHHGFLDAR
>NZ_CP016793|5038097:5093795|5071254_5071881_+|WP_065917196.1|DBSCAN-SWA
MIHEVDEALRRLVRDEALRGSDLDVAFDAPTKDWAARRNAPTVNIYLYDIREDMRRRQRGLLNEYDAQGQVAARHLPPRHMKLSYLVTAWTQRAEDEHRLLSDLLVGFLRYDAVPPPLLTGSLEALALPVPMTVALPPPEDRAFADVWSALGGELKPSLDVVVSAPVSSGRKVDAGPPAREGVQLNTGADRVRHTVSGDGVSMRRVTQ
>NZ_CP016793|5038097:5093795|5061106_5061826_-|WP_065917186.1|DBSCAN-SWA
MTPDQHAAFEDLARTARDSPRYYALRDRLVREYLPLARHIARRFSERGEPMEDLAQVAAVGLINAIDRFDVDRQTDFLSYAVPTITGEVRRHFRDQCWAVRVPRRLKELCDAIDGATAELSHRSGRSPTPSEIARHLGIGLADVYEGLRVEKNVAFAPLEALEENTVDDPALEGVEIHEALQPMLRGLPRRERTIVVLRFFGRLTQTEIARRVGISQMHVSRLLTKSLDQLRNDLLADE
>NZ_CP016793|5038097:5093795|5051397_5051613_-|WP_065921332.1|DBSCAN-SWA
MIARMIVDWAVALQARGSWVPKVQRVTYAVTEPVLSPVRKVLPPVRFGGFGLDLAFTVVFIAALVLRSIVS
>NZ_CP016793|5038097:5093795|5083126_5084641_+|WP_065917204.1|tail|DBSCAN-SWA
MPTYLSPGVYVEEVEAGARPIEGVGTAVAAFVGFAAKGEYNTPTLVSNWAQYTEKFGDFAEGCYLPLAVYGYFLNGGNNCYVVRVGGDKATPALPAGAQGVLGGYRVAARELSASSLSVEVADPAGENPPDDRFSVVVKDNGKVVETHQVSAKRGKENVVTVVNAASKLITITEVAGAPVAKPDKTSVALREAQAPPPVPRKVVPDDYVGDVADRTGFGGLEAIDEITMVSVPDLMSSYQRGLITLEGVKTVQAAMIAHCELMGDRMAILDPPPDLSPDQVKNWKQTEAGYDSKYATLYYPWVKVYDPSTSDNVFVPPSGHMAGIWARTDAARGVHKAPANEVVRGAVALHTQLTKAEQELLNPIGVNCIRSFTGRGIRVWGARTLSSDPAWRYLNVRRLFNYLEESIMDGTQWVVFEPNDDALWARIRRTISAFLVMEWRKGALFGLTPDEAFYVKCDRETNPAEGIDLGQVICEVGVAPVKPAEFVVFRLAQIQGGTSLVNE
>NZ_CP016793|5038097:5093795|5084665_5085109_+|WP_065917205.1|tail|DBSCAN-SWA
MALPELDTSVGHSFGLEVDGITIKQISEVTGLKMEQDVIELKQNTSDGKYVVKKLPGRKKAGEVTFTRGLTGDNSFERWVKDAQFGKMGAARKNGVVVVYDYEGQPIKRYKIMHAWPKSLEIGSLKAGDTSVLTEKLVVTYEEMEVE
>NZ_CP016793|5038097:5093795|5089382_5091152_+|WP_065917211.1|DBSCAN-SWA
MANESFANNLVVEVDGQALPADVKLLLTYAYVDDSRNLPDMFVLRFRDPGHVVLNKGGFKIGARTALKVQTADPGGPKPLMSGEITAVGVELDGQGTFTEVRGYDEAHRLFRGTRVAVYPNMTVADVVRKVAQRAKLKTGTIDDVKGFGGRPDTQLSQDNVSDWEFLSRLAKAVGAQIAVKDGKLDFRLPEPPTAAPKPNAKAKTNPLVLELHSTLVALRAGLTTAGQVPEVQVRGWDFENKQEIVATAVPTTAGVEVPQANPAELAKKFGAPPHLEAGLPYRTHAEAKTAADALAAQLGGSCAELTGVARGNPNLKAGTAVALTNVGEPFQGRYTLTSTRHLFAEHTGYTTEFTVSGRQERSLYGLTHGTKAKLLNGLVPAVVTNAKDPLNLGRVQLKFPWLSADFTSVWARTVQAGAGAGRGMLVLPEVGDEVLVGFEHGDLDAPYVLGGLHNGKDRPPELGKPPVDGGNGEIAVRGFVSRKGHKVELVEDEGIVISSGDGKFVVKLDQKAQTVEITSGGKVTVGARNGITVDAGTGPLELKGRNVAIKAAAELKAEGVQVKVAGQAQTEVTADGVLTVKGSIVKIN
>NZ_CP016793|5038097:5093795|5079281_5080232_-|WP_065917201.1|DBSCAN-SWA
MKHRLLITVFAAVLLAGVAVGYTALSASTGEAAHSISAGSASGPRLLVLSNGQLTTVSSTDPNGPREVTAQRCDRVYGAAGTISCLRPVGALKAGELAVLDSRLNELRTVPLTGFPNRTRVSASGRMVAWTLFVDGHSYAANGFSTSTGILDTKTGALVRSLEEFSVEGMAQLPADANFWGVTFTADDNRFYATMSTAGHRYLVEGDFAARKARTLVDNVECPSLSPDGTRIAYKAAVGGDPQRGWRVSVLDLATREITPLADTRNVDDQPAWIDDRTVAYGIQRDDGTNDVWAEPADGSGEARVLVPDASSPAPW
>NZ_CP016793|5038097:5093795|5070727_5070991_+|WP_065917195.1|DBSCAN-SWA
MFVRPPAALRWSARLGYERVSELLTAIRAAESCSVPDVELTYVPDQRTGEAELACATGSVLLAAAEVLLLHDALRAHMPDRMRPLPA
>NZ_CP016793|5038097:5093795|5066854_5068063_-|WP_071812663.1|transposase|DBSCAN-SWA
MRTAYRCRAYPDPEHAAVLNRTFGCVRLVWNKTLSERHGVYHVEGKRTTCRETDAALTRWKRTEDLAFLSEVSSVPLQQTLRHQHTAFANFFAGRAGYPRFKTRRGRQSAHYTRSAFRLRDGVLNLAKTSTPLRFVWSFDNVDITALDPTTVVVSREPDGRWYVTFAVDAEAPEAADPTGHAVGVDLGLTDFPVTSDGRRIPNPRHLDRRARRLARYQRRMARCRRGSRNRSKARAKAAGAHRKVRNARQDFLHRITTALVRSAEVIAIEDLDISGMVRSHHLARAISDASWGEFRRQLEYKCARAGRTLVVIDRWYPSSKTCSACGHQLAELGLTTRHWTCPGCRARHDRDHNAAKNILAAGRAVARGSSGDACGADVRRQGSSLPRSAMKQETRVVRHSA
>NZ_CP016793|5038097:5093795|5049881_5051435_+|WP_065917176.1|DBSCAN-SWA
MTTRSWWGWGNVEHAVTPEERQKLVDRVRAVLPNADLTLHDPPDPETLTIPKSRIQPSPLYSTDPLDRLTHARGQAYRDVVRNLAGDIGTVPDAVARPRTEQDVVDVLDHCGSNGIAVIPFGGGTSVVGGVEPRDIDGPVVTLDLGHLDRVLEVDPTSRAARIQAGVLGPDLEAQLKPHGFTLRHFPQSFEFSTLGGWLATRAGGHYATATTHIDDFTESLRVVTPVGVSESRRVPGSGAGPSPDRMFLGSEGALGVITEAWMRVQEPPRHRAGASVRFADWGRAVEAVRAIAQSGLHPANCRLLDPAEAFLNAGSSQSVLVLAFESADHPVDAHLRRALELCAGGEVVEGTAARWRGSFLRMPYQRDAMAQHAMITETFETACTWDRFAELHAAVTEAATSVLEEVCGAGIVTCRFTHVYPDGPAPYYGVYAPGRWGSLRQQWDEIKVAVSEALTGAGGTITHHHAVGRDHMPWYLRQRPDVFGTALTAAKAALDPAGVLNPGVLTTRSTAGPAPR
>NZ_CP016793|5038097:5093795|5043884_5046407_+|WP_083268864.1|DBSCAN-SWA
MARAVLRATEDRSEWAIAERAIGLALRELHDYSGSIRHLRRSIRIATDASLPRLSALAQMSLAWVLAYTGRHRAALRALDVAMPSLSGADAVAALMQRGVVFHYLTRYSEAQRDYTAAIAGARRVDDKLVEARAHNNRGLVRAYVGNMREASADFDVAASLLGSLGQELGVADVHWNAGIMATRSGDVPAALTLFDKADEVYRRLDVPRPALLVNRLELLVSVPLVDEARVAADRAITELKALRNPFATSEALFFRARIALLDDDLDAAHVFAAEARRRFRREQRLLWAAGARYLELHAAVLRGDRTRSLRVALSRVADELDAMDWRLPALEARIDAGLVAADLGHRVRAVAEFSRAAASRSRGPAGLRVRGWYAEALRRKLSGDVRGTSSALRRGIALLDEYRVSLGAAELRALTGAQGQALAAEGLRLAVASGNAARVLSWTESWRAGALRMKSVSPPDDPRLEDALASLRAVTSDVESAVLAGKPAGALRVQLVRAEQRVRDLTRQMSGGGAVFKPPSMASLAAALGSAALIEFVEYDGSLLAVVLVDGRTSLHSLGALEGVVREIRLLRFALHRLVTLPPNLPNLSVARSSAAHAASLLSTRLLEPLASRIDGRPLVVVPTGALNSLPWAVLGREVTVAPSASVWLRAAAAPDASGEAVLAAGPRMAAAPEEIKAISAHVPGRVLVDDDATVSAVASAMDGAALAHIAAHGSFRVDNPLFSALELADGPLTVYDIERLRTPPTRVVLSACDTGQSAVRPGDELMGFTAALLGLGTRTLIAPVVPVPTDGTAPVMVELHRKLAAGLSPAEALAEVQRSAADDASYAAAVGFVCFGAG
>NZ_CP016793|5038097:5093795|5075212_5075929_+|WP_065917200.1|DBSCAN-SWA
MRGFEHESETSPRPKGDRLSHDGSDLLGRAAAANRPEVLGAAGLLDLQRAVGNAGVTSVVEEERSPVHGVLSSGGAPLDANVRADMEGRFGQDFSDVRVHTDSAAHASAQSVNAQAYTVGSNIVFQRDRYDPASAAGQHMLAHELTHVVQQRSGPVDGTDAGGGVKVSDPSDRFEREAVSTADRIMSAPSPVAPVQRCEDEAVQRVVVQREDAPPAEEEEPAAQTFVQRAEEEEEAAE
>NZ_CP016793|5038097:5093795|5056754_5057450_+|WP_065917181.1|DBSCAN-SWA
MDVLVTGGNKGLGLETVRQLATAGHTVWLGSRDLERGRVAAAEVGARAVQLDVTSDESVAAAVRMVGSLDVLVNNAGVSPERGPGWFVETADLTAEVLRETFETNVAGTVRVLHAFLPLLERSEAPVVVNVSSRLGSLSTVAAPGSPQHDYPGAAYPASKAALNMLTIQYAKAFPRMRINAVDPGFTATDLNDRTGTQSAAEGAAIIVRMAQVGPDGPTGGYFDGSGPLPW
>NZ_CP016793|5038097:5093795|5088658_5089390_+|WP_065917210.1|DBSCAN-SWA
MTVTFTSAGSATTSKKMEHASITVHEPPKPGGLQQPGTKLSEIKFQFNPKELTLAKNAKWQRQTQPNAAKSGVPEFKGAEPAKLQLEIFLDSTDTMGDATIKLVEELFNLTVPTKDSRTNGKGSPPWVIFKWGTTTGFPSFVSSVSAKYTLFTPGGMPVRAVCTVSLEEVSGEPGGQNPTSGAKEARGAHVLTAGDSLQSLAYRAYGNPELWRHIAEANGIDDPMRLRLGSTLLVPALEEIDG
>NZ_CP016793|5038097:5093795|5073841_5074282_+|WP_065917198.1|DBSCAN-SWA
MRAFESKPFNQKKTVAARSSAAPSGLHALQQSAGNRAVAGMLALQRVDHLLESPPSARGEVVEGTFDRDPLYLDNFTGGGFEVLTGLFRLMYADGRAVDFRYADVIRQLRTGASESALLPAAADTAAGSRTVRLAVRFTTGARTPG
>NZ_CP016793|5038097:5093795|5081473_5082835_-|WP_065917203.1|DBSCAN-SWA
MSRRRAPLAVLTTVVITAATITASTSAQAATTTFTATADTYVDNAAASTNYGTSGQLGVDNSPVKRMFLKFAVSGLTEAVTNAKLRIHTDDVSGAESPNGGTFRAMSSTSWSEAAVTANAQPAIDGATLGSLGAVVRNAWYEVDVTSYVTGNGTFSIGVTSSSTDGADYDSRESGATTAPRLVITTGSTQPGNDPVFVGAGDIADSGSGDSATAALLDNIQGTVWTTGDNVYPDGTLSQFNSYYEPTWGRHKARTRPSPGNHDYHTSGASGYYSYFGAQAGPSGRGYYSYDIGNWHIVSLNSNISMSAGSAQEQWLRQDLAASTKPCTAAYWHHPLFTSGANHAPSTATRPLFQALYDYNADVVLFGHNHQYERFAPQNPSGALDTARGIRTFVAGMGGAGAYGFGTIKPNSEARNTGTRGVLKLTLHSNSFDWQFVPESGKTYTDSGTTNCH
>NZ_CP016793|5038097:5093795|5063285_5064065_+|WP_065917189.1|DBSCAN-SWA
MAVLSVADIRLAFDGVVAVDGVSFEVGEGELFAVIGPNGAGKTSIFNVLSGVYRPQRGTVRFHDQDLVGMRPHRIAALGMARTFQNIELFSHLTVVDNLMLGRHNHMRYGALSAFLWLGRARREELENRAAVEGVIDFLELEQWRRLPVGLLPYGVQKRVELGRALAMEPKLLLLDEPVAGMNVEETEDMARFILDVREELNIAMIMVEHDMGLVMDLADRVMVMDFGRPIRTGTPAEVQSDPDVIRAYLGEQHRSVTP
>NZ_CP016793|5038097:5093795|5038675_5040337_-|WP_065917170.1|DBSCAN-SWA
MRRTLEVLSPEFGPDVLGGLAAGYVRATREQIFAEQEKVKNSLLKAVEDAQRDLHDSEARFAQVFASTAVGIAIFDLHGAVVEANEAMATIMGHEEVPRELFTDEDLTAFAAAFKRMIESTVDTERREWELTRENGDTVWANAVLSVLRGSDGLPKFHVALIEDVTEQRMLQEWLRRQALTDLLTGLPNRSSFVDRLEGALASGEPCTLAYLDVDSLTIVNDGLGYEAGDAVLVEVARRLRAVLPDAVVARIGGDEFVVLVQGSPDVAALAAMIDEELAEPVYLEGAGVAVSTSIGFVHTPGSGVTATALLRRAHSTLRRAEAGGKRQWAIYDHEADASDRARFARIAAMPGAFENGEISVEYAPVSWAAGGLAFVEASLRWGETRHDECVAHADALGLAARVGELVLHDACSRGEPVLIRLSRDLSRDPDLAALVRSALRDCALEPSSLFLALDVRAMPDGEENLEVLHDMGVRVLLHEFGGGFAGLSTVDRNAVWGVRLAEPPPERLARQGLALMVPLLRSAGVHVIAGPGDPDELHALGVDLIVTRSTDS
>NZ_CP016793|5038097:5093795|5085648_5085954_+|WP_154697482.1|DBSCAN-SWA
MWPFRRSVALPVVRADWRTLPPLQRVVGAHPLINPVGGFSSRLASWQNPSSLAPLGHVVSAGAPSGSVSGVVSEAVGGAGVFPAAPVVARAVEAGEPSSVG
>NZ_CP016793|5038097:5093795|5065913_5066801_+|WP_065917191.1|DBSCAN-SWA
MDEFLQSLIRGLGTGSIYSLLALGFVIIYKSTQVISFAQPAFMLAGAVLVSYLSPAVSFYGAVLVAALVIAVLALGVERTVLRPMVGKPVFVVAIITIGVDVVVRVVTNAFIGLDVRQVGDPWGLDTVSFLGAEVQQRYLVMIGTTAVVTVGLFLFFRYSRIGLAMRAVAYDQEVALAQGISVGSVFALSWALAGGLAALAGVFVATGAGVDQQLWIVALKALPAIILGGLESLGGAVVGGLAVGIVESLFGTYQNDFAPWLGPNFGLVAPYALMLLVLLVRPYGLFGKREVERL
>NZ_CP016793|5038097:5093795|5069314_5070601_+|WP_065917194.1|DBSCAN-SWA
MLRKRFAVVFVGVLALASCRGGDGAAPQEGAGGIKVDFGVTKEACPQAVDKTKGCIYLGTISDLTEGPFKTLAVPITDSQKAFWKRVNDRGGIGGYEVDVTKYVKDNKYNPQIHNQVYQEIKGNILALTQTLGSPTTAAILPDLENTQMVSVPASWTSLWGFEEVVLESGANYCVESMNTVDYAVEKLGVKSVMAVHLAGDYGDDAAAGAKIAAEKRGLTFESLTTQTGQDNQGGAIDAVVSKKPDLVVLTTGPTDAAVIIGQAAARGYKGKFIGTSPTWNPGLLKSPAAPAIKALYYQSAPWKAWGTESVGHTAMRAALTGVTPNDGYTAGWVWAYPLKAALEKAAANKDMTRAGVLAAVRQLTSVDYEGMLPSGAGNFAASPQDAAFRQTLIYKPDDAAATGVSLVEDFYTGSTAKDFKFEKPCYQ

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065917169.1|5038097_5038613_+|protease	snapalysin family zinc-dependent metalloprotease	NA	NA	NA	NA
WP_065917170.1|5038675_5040337_-	diguanylate cyclase	NA	NA	NA	NA
WP_065917171.1|5040521_5041322_-	SAM-dependent methyltransferase	NA	NA	NA	NA
WP_065917172.1|5041422_5041869_-	hypothetical protein	NA	NA	NA	NA
WP_065917173.1|5041846_5042476_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_065921331.1|5042541_5043741_-	S8 family serine peptidase	NA	NA	NA	NA
WP_083268864.1|5043884_5046407_+	CHAT domain-containing protein	NA	NA	NA	NA
WP_065917175.1|5046408_5049783_-	NACHT domain-containing protein	NA	NA	NA	NA
WP_065917176.1|5049881_5051435_+	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_065921332.1|5051397_5051613_-	YggT family protein	NA	NA	NA	NA
WP_065917177.1|5051747_5052335_+	hypothetical protein	NA	NA	NA	NA
WP_065917178.1|5052338_5053826_-	Nramp family divalent metal transporter	NA	NA	NA	NA
WP_065917179.1|5053937_5056262_+	immune inhibitor A	NA	NA	NA	NA
WP_083268865.1|5056290_5056719_+	nucleoside deaminase	NA	NA	NA	NA
WP_065917181.1|5056754_5057450_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_170067960.1|5057458_5057821_-	anti-sigma factor antagonist	NA	NA	NA	NA
WP_154697479.1|5057841_5058609_-	iron-containing redox enzyme family protein	NA	NA	NA	NA
WP_065917183.1|5058608_5059679_-	glutamate--cysteine ligase	NA	NA	NA	NA
WP_065917184.1|5059728_5060652_+	DNA topoisomerase IB	NA	NA	NA	NA
WP_065917185.1|5060638_5061064_-	DUF4383 domain-containing protein	NA	NA	NA	NA
WP_065917186.1|5061106_5061826_-	SigB/SigF/SigG family RNA polymerase sigma factor	A0A0Y0AU18	Bacillus_phage	3.3e-19	32.5
WP_065917187.1|5061838_5062306_-	SRPBCC family protein	NA	NA	NA	NA
WP_065917188.1|5062524_5063298_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.6e-16	27.6
WP_065917189.1|5063285_5064065_+	ABC transporter ATP-binding protein	A0A2R8FG22	Brazilian_cedratvirus	9.3e-12	23.7
WP_065917190.1|5064061_5065921_+	AMP-binding protein	A0A1V0SBX8	Catovirus	8.7e-56	26.4
WP_065917191.1|5065913_5066801_+	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_071812663.1|5066854_5068063_-|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A220NS37	Mycobacterium_phage	1.4e-128	61.8
WP_065917193.1|5068200_5069301_+	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_065917194.1|5069314_5070601_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_065917195.1|5070727_5070991_+	hypothetical protein	NA	NA	NA	NA
WP_065917196.1|5071254_5071881_+	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_065917197.1|5071877_5073842_+	ATP-binding protein	K9MCS8	Sulfolobus_virus	7.1e-08	30.7
WP_065917198.1|5073841_5074282_+	hypothetical protein	NA	NA	NA	NA
WP_065917199.1|5074341_5075100_+	hypothetical protein	NA	NA	NA	NA
WP_065917200.1|5075212_5075929_+	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_065917201.1|5079281_5080232_-	hypothetical protein	NA	NA	NA	NA
WP_065917202.1|5080228_5081440_-	MFS transporter	NA	NA	NA	NA
WP_065917203.1|5081473_5082835_-	DNRLRE domain-containing protein	NA	NA	NA	NA
WP_065917204.1|5083126_5084641_+|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	3.6e-68	35.8
WP_065917205.1|5084665_5085109_+|tail	phage tail protein	NA	NA	NA	NA
WP_154697481.1|5085132_5085501_+	hypothetical protein	NA	NA	NA	NA
WP_170067961.1|5085497_5085641_+	hypothetical protein	NA	NA	NA	NA
WP_154697482.1|5085648_5085954_+	hypothetical protein	NA	NA	NA	NA
WP_065917207.1|5087465_5087945_-	hypothetical protein	NA	NA	NA	NA
WP_065917209.1|5088233_5088662_+|tail	phage tail protein	NA	NA	NA	NA
WP_065917210.1|5088658_5089390_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_065917211.1|5089382_5091152_+	VgrG-related protein	NA	NA	NA	NA
WP_065917212.1|5091174_5091459_+	PAAR domain-containing protein	NA	NA	NA	NA
WP_065917213.1|5091459_5091870_+	GPW/gp25 family protein	A0A1D8KT65	Synechococcus_phage	9.3e-11	37.8
WP_065921334.1|5091869_5093795_+|plate	putative baseplate assembly protein	NA	NA	NA	NA