CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP016824	Streptomyces sampsonii strain KJ40 chromosome, complete genome	38 crisprs	WYL,cas4,c2c9_V-U4,DEDDh,Cas9_archaeal,csa3,cas3,DinG	5	27	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP016824_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_1

1386541-1386627

Orphan

Consensus_repeat	Method
TGGCCTCAAGCGCCGGCCGGGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_1

>merge|NZ_CP016824|1|1386541-1386627|CRISPRCasFinder
TGGCCTCAAGCGCCGGCCGGGCTGGGTTTTGGTGCGGACACCTCTGACCGTGCGGGTCACCGATGGCCTCAAACGCCGGCCGGGCTG

>NZ_CP016824|1|1|1386541-1386627|CRISPRCasFinder
TGGCCTCAAGCGCCGGCCGGGCTG	GGTTTTGGTGCGGACACCTCTGACCGTGCGGGTCACCGA
TGGCCTCAAACGCCGGCCGGGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067411216.1\|1379853_1381608_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378382
NZ_CP016824.1\|WP_067411221.1\|1388649_1390503_-\|phosphonate-metabolism-protein	unknown	unknown	gnl\|CDD\|132992
NZ_CP016824.1\|WP_067411214.1\|1379359_1379782_-\|Rieske-(2Fe-2S)-protein	unknown	unknown	gnl\|CDD\|239550
NZ_CP016824.1\|WP_067411211.1\|1376568_1379283_-\|excinuclease-ABC-subunit-UvrC	unknown	unknown	gnl\|CDD\|234792
NZ_CP016824.1\|WP_049978183.1\|1393562_1394498_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225837
NZ_CP016824.1\|WP_003947462.1\|1373598_1374588_-\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NZ_CP016824.1\|WP_003947463.1\|1374578_1375640_-\|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK	unknown	unknown	gnl\|CDD\|211689
NZ_CP016824.1\|WP_003947461.1\|1372252_1373260_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|223135
NZ_CP016824.1\|WP_003947464.1\|1375636_1376572_-\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|235450
NZ_CP016824.1\|WP_067411230.1\|1396455_1397832_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP016824.1\|WP_067411227.1\|1395845_1396406_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|223427
NZ_CP016824.1\|WP_003947469.1\|1385057_1385753_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|236578
NZ_CP016824.1\|WP_003947474.1\|1390655_1391234_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NZ_CP016824.1\|WP_067411224.1\|1391375_1393523_-\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NZ_CP016824.1\|WP_003947481.1\|1397777_1398275_-\|dioxygenase	unknown	unknown	gnl\|CDD\|319916
NZ_CP016824.1\|WP_067411219.1\|1381778_1384784_-\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NZ_CP016824.1\|WP_026235322.1\|1387357_1388371_-\|TerC-family-protein	unknown	unknown	gnl\|CDD\|274743
NZ_CP016824.1\|WP_030767779.1\|1394869_1395811_+\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176543
NZ_CP016824.1\|WP_030767793.1\|1385801_1386458_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NZ_CP016824.1\|WP_030308389.1\|1386776_1387250_-\|type-II-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|235443

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067411216.1\|1379853_1381608_-\|hypothetical-protein	gnl\|CDD\|378382	pfam10081, Abhydrolase_9, Alpha/beta-hydrolase family. This is a family of alpha/beta hydrolases which may function as lipases. This domain is the catalytic domain and includes the catalytic triad and the GXSXG sequence motif which is a characteristic of these enzymes.	3.59028e-145
NZ_CP016824.1\|WP_067411221.1\|1388649_1390503_-\|phosphonate-metabolism-protein	gnl\|CDD\|132992	cd06974, TerD_like, Uncharacterized proteins involved in stress response, similar to tellurium resistance terD. Tellurium resistance terD like proteins. This family is composed of uncharacterized proteins involved in stress response, such as the tellurium resistance proteins, chemical-damaging agent resistance proteins, and general stress proteins from a variety of organisms. The tellurium resistance proteins are homologous terA,-D,-E,-F,-Z,-X gene products, which confer tellurium resistance mediated by plasmids. Currently, the biochemical mechanism of tellurium resistance remains unknown. The family also contains several ter gene homologues, YceC, YceD, YceE, for which there is no clear evidence for any involvement in the tellurium resistance. A putative cAMP-binding protin CABP1 shows a significant similarity to the terD protein and is also included in this family.	3.26498e-17
NZ_CP016824.1\|WP_067411214.1\|1379359_1379782_-\|Rieske-(2Fe-2S)-protein	gnl\|CDD\|239550	cd03467, Rieske, Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. The Rieske domain can be divided into two subdomains, with an incomplete six-stranded, antiparallel beta-barrel at one end, and an iron-sulfur cluster binding subdomain at the other. The Rieske iron-sulfur center contains a [2Fe-2S] cluster, which is involved in electron transfer, and is liganded to two histidine and two cysteine residues present in conserved sequences called Rieske motifs. In RO systems, the N-terminal Rieske domain of the alpha subunit acts as an electron shuttle that accepts electrons from a reductase or ferredoxin component and transfers them to the mononuclear iron in the alpha subunit C-terminal domain to be used for catalysis.	1.01225e-19
NZ_CP016824.1\|WP_067411211.1\|1376568_1379283_-\|excinuclease-ABC-subunit-UvrC	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	0
NZ_CP016824.1\|WP_049978183.1\|1393562_1394498_-\|hypothetical-protein	gnl\|CDD\|225837	COG3300, COG3300, MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms].	2.12497e-43
NZ_CP016824.1\|WP_003947462.1\|1373598_1374588_-\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	1.19405e-138
NZ_CP016824.1\|WP_003947463.1\|1374578_1375640_-\|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	1.58187e-97
NZ_CP016824.1\|WP_003947461.1\|1372252_1373260_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	2.99384e-178
NZ_CP016824.1\|WP_003947464.1\|1375636_1376572_-\|RNase-adapter-RapZ	gnl\|CDD\|235450	PRK05416, PRK05416, RNase adapter RapZ.	3.61221e-164
NZ_CP016824.1\|WP_067411230.1\|1396455_1397832_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.85952e-25
NZ_CP016824.1\|WP_067411227.1\|1395845_1396406_+\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	1.76603e-47
NZ_CP016824.1\|WP_003947469.1\|1385057_1385753_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|236578	PRK09583, PRK09583, mycothiol-dependent maleylpyruvate isomerase; Reviewed.	3.93796e-65
NZ_CP016824.1\|WP_003947474.1\|1390655_1391234_-\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	1.01169e-53
NZ_CP016824.1\|WP_067411224.1\|1391375_1393523_-\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NZ_CP016824.1\|WP_003947481.1\|1397777_1398275_-\|dioxygenase	gnl\|CDD\|319916	cd07253, GLOD5, Human glyoxalase domain-containing protein 5 and similar proteins. Uncharacterized subfamily of VOC family contains human glyoxalase domain-containing protein 5 and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.93997e-20
NZ_CP016824.1\|WP_067411219.1\|1381778_1384784_-\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_CP016824.1\|WP_026235322.1\|1387357_1388371_-\|TerC-family-protein	gnl\|CDD\|274743	TIGR03718, R_switched_Alx, integral membrane protein, TerC family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains TerC itself from Alcaligenes sp. plasmid IncHI2 pMER610 and from Proteus mirabilis. It also contains the alkaline-inducible E. coli protein Alx, which unlike the two TerC examples is preceded by a yybP-ykoY leader.	9.5976e-143
NZ_CP016824.1\|WP_030767779.1\|1394869_1395811_+\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176543	cd08601, GDPD_SaGlpQ_like, Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized glycerophosphodiester phosphodiesterase (GP-GDE, EC 3.1.4.46) from Staphylococcus aureus, Bacillus subtilis and similar proteins. Members in this family show very high sequence similarity to Escherichia coli periplasmic phosphodiesterase GlpQ, which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	2.77214e-76
NZ_CP016824.1\|WP_030767793.1\|1385801_1386458_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	3.28573e-39
NZ_CP016824.1\|WP_030308389.1\|1386776_1387250_-\|type-II-3-dehydroquinate-dehydratase	gnl\|CDD\|235443	PRK05395, PRK05395, type II 3-dehydroquinate dehydratase.	2.05531e-86

>NZ_CP016824.1|WP_030767793.1|1385801_1386458_+|MBL-fold-metallo-hydrolase
MTYSGAVKVGGPADVHELTGLMISKVAVGPMDNNAYLLRCRATGEQLLIDAAAEPGTLLQLIGRDSVASVVTTHRHGDHWQALAEVVAATGARTQAGRYDAEGIPVPTDVLLDDGDTVRVGRVELTVLHLVGHTPGSIALVYDDPHGHPHVFTGDCLFPGGVGNTHQDPDAFAQLLGDVETKIFAALPDETWVYPGHGDDTTLGAERPDLAAWRERGW
>NZ_CP016824.1|WP_003947469.1|1385057_1385753_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MTDPVRDLTRLDEATARLLTVAGTLDDAALAEPSRLPGWTRGHVLSHLARNADALLNVVAGRPMYASAEARDADIEAGATLPAEALAEEVRLSAARLAAALAEPGDWERVVELRNGVTDRLARVPFRRLVEVELHQVDLGAGRELEDLPAEFTDAENAFLADRFTGHPDVPPLLLRPAGSPALTSGRAAAPGEEPLTVTGTPADLLGWLAGRRAPDGLKTDGGPLPALPPL
>NZ_CP016824.1|WP_067411219.1|1381778_1384784_-|excinuclease-ABC-subunit-UvrA
MADRLIVRGAREHNLRNVSLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSSYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITEVYDYLRLLFARIGKPHCPVCHRPISRQSPQAIVDKVLGLPEGSRFQVLSPLVRERKGEFVDLFADLQTKGYSRARVDGTTVQLSDPPKLKKQEKHTIEVVVDRLTVKESAKRRLTDSVETALGLSGGMVVLDFVDLPQDDPERERMYSEHLYCPYDDLSFEELEPRSFSFNSPFGACPDCTGIGTRMEVDPELIVPDEDKSLDEGAIHPWSHGHTKEYFGRLVGALADALNFRTDVPFAALPQRAKKALLQGHKTQIEVRYRNRYGRERVYTTAFEGAVPYVKRRHSEAESDSSRERFEGYMREVPCPTCEGTRLKPIVLAVTVMGKSIAEVSAMSITDCADFLDKLTLSGRDLKIAERVLKEVNERLRFLVDVGLDYLSLNRPAGSLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNHRLIETLVRLRDMGNTLIVVEHDEDTIKVADWIVDIGPGAGEHGGKVVHSGSLDELLANKESITGQYLAGKRSIPVPEIRRPVDPARQLTVIGAKENNLRDIDVSFPLGVLTAVTGVSGSGKSTLVNDILYTHLARELNGAKSVPGRHTRVEGDDLVDKVVHVDQSPIGRTPRSNPATYTGVFDNVRKLFAETMEAKVRGYLPGRFSFNVKGGRCENCHGDGTIKIEMNFLPDVYVPCEVCHGARYNRETLEVHYKGKSIAEVLDMPIEEALGFFEAVPTIARHLRTLNEVGLGYVRLGQPAPTLSGGEAQRVKLAAELQKRSTGRTVYVLDEPTTGLHFEDISKLITVLSGLVDKGNSVIVIEHNLDVIKTADWVVDMGPEGGNGGGLVVAEGTPEEVAGVPASHTGKFLQDVLGADRISEASAAPRSGGARKTGATRKAVAAKKPAAKKTAAKKTAAKKAPAKKAPRTTK
>NZ_CP016824.1|WP_067411216.1|1379853_1381608_-|hypothetical-protein
MIAMGSTARSLAGRVAAAARKPYWRRPGPTYLVRRWPDLTATCVATVFFWFSLTPSLVPRPWFLQGLIGGINAAIGYALGVTLSWLFRLLVARRPSQAVRAYAWQAYFLISPVCAVWLISESAHLQRQLRALQGLAPSLTWHTPMIALITVALWAVLLLLARAVRLGASRLIRLLGRLLPRPAAVGLGLLLSSLAVLFCVQDLVFERGVVDVADRISKATDGGTKEGVTPPTSRLVSGGPGSYIRWRDLGFQGRNFAGSVLTSEEITDWTGRDAVDPVRIYAGSAAPEAFAYDEDPVAAQVDLAMKELDRTRAFERDVLAIAGTTGTGWVNANVVEPLEYMHDGNTATVALQYSYLPSWLSFLVDKEKAAHATRELVDAVRARWAALPPDERPLLVVTGESLGAYAVEASYERPGELLDNVDGALLLGPPNFSPISQEIRAHRDPSSPVWRPLYEEGRHFRFAQFPRRDLARPAGPWQEPRVVYLQNASDPVVWWSYDLLLQRPAWLDDPLGPDITPEITWFPFVTFWQTSVDMAVSYGVQAPHGHRYGASPVDGWAAVAPREGWTDADTRRLHDFIASRDTPY
>NZ_CP016824.1|WP_067411214.1|1379359_1379782_-|Rieske-(2Fe-2S)-protein
MSAHPLSRRTVLRGAALVPAAGLGAAACAPPDDGRAEGPAEPVELGSAEAVPKGGAEIFREHHVVVSRSEAGEYRAFSAVCTHRSCPLHQIKGTVSTCTCHGSRFDVTTGEVLRGPAVAPLTELDVSADGGRLVARARPA
>NZ_CP016824.1|WP_067411211.1|1376568_1379283_-|excinuclease-ABC-subunit-UvrC
MADPSSYRPKPGQIPDSPGVYRFRDDHRRVIYVGKAKSLRQRLSSYFQDLAGLHPRTRTMVTTASSVEWTVVSTEVEALQLEYTWIKEFDPRFNVKYRDDKSYPYLAVTMNEEFPRVQVMRGQKKKGVRYFGPYGHAWAIRDTVDLLLRVFPVRTCSAGVFKNAARTGRPCLLGYIGKCAAPCVGRISPEDHRDLAEEFCDFMAGRTGAYLRRLERQMQEAAEEMEYERAGRLRDDIEALRRAMEKSAVVLADATDADLIAVAEDELEAAVQIFHVRGGRVRGQRGWVTDKVEAVDTAGLVGHALQQLYGEERGEGVPKEVLVPALPENTEAVSQWLGDRRGTQVSLRIPQRGDKKSLMETVQRNAQQSLVLHKTRRASDLTTRSRALEEIAEALELESAPLRIECYDISHFQGDDVVASMVVFEDGLARKSEYRRFQIKGRAGDTQLWHGQGQDDVRSMHEVITRRFRRYLSDRERTGEWTEEQDATEGGEVTASLTDEDGRPKRFAYPPQLVVVDGGQPQVAAAQRALDELGIDDIAVCGLAKRLEEVWVPGQDDPVVLPRTSEGLYLLQRIRDEAHRFAITYQRAKRSKRIRTSPLDDVPGLGETRKQALVKHFGSVRKLRAATVEQICEVPGIGRKTALAVAATLAQSAPSVAVNTATGEIVGNDDTDESPERGGAPATPGESDGPDTAGGTGPSTPESWGADRPASGSEGEQGSPADGSAQGDGPSAEPVEGEPVGSGEAEPGAEGPGGPLAAGLPQDEPAPQQTAPAPPALGLPQDGPRSHGDALPLVHPAPSAPQPGDARTARVPGEGDAPPIQGVAPQPAQGEAAPGEGVAAGPGGNSPGPHRAAGSPDGGAAGQTGDPEVSGPAEQEWPGDRTAPDGGPDQAPPQTAPKNRGQQT
>NZ_CP016824.1|WP_003947464.1|1375636_1376572_-|RNase-adapter-RapZ
MTEHDGDEAQVGTGTTGEAVEATETAIPELVIISGMSGAGRSTAAKCLEDLGWFVVDNLPPALIPTMVELGARSQGNVARIAVVVDVRGRRFFDNLRESLADLDVKNVTRRIVFLESSDDALVRRFESVRRPHPLQGDGRIVDGIAAERDLLRELRGDADLVIDTSSLNVHELRAKMDAQFAGDEEPELRATVMSFGYKYGLPVDADLVVDCRFLPNPHWVPELRPFTGLNEEVSNYVFSRPGAKEFLDQYTELLQLIARGYRREGKRYVTIAVGCTGGKHRSVAMSEKLASRLASEGVETVVVHRDMGRE
>NZ_CP016824.1|WP_003947463.1|1374578_1375640_-|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK
MTGRPSRLRRMRRTTPPAAPLGWTPRPRPRGRGAQPKVVALGGGMGLSASLTALRRITGDLTAVVTVADDGGSSGRLRDELGVLPPGDLRKALAALCGDDDWGQTWSRVIQHRFHSRGDLHDHAVGNLLIVALWEQLGDHVQALDLVGTLLGAHGRVLPMSAVPLELQALVRGHDPARPDDVDTVRGQATVALTPGEVQSVHLVPHDPPAVPEAVEAVLDADWVVLGPGSWFSSVIPHLLVPELLDALLSTKARRVLSLNLAPQPGETEGFSPQRHLEVLARHAPKLALDVVLADEAAVPDRLSLDDAARRLGATVELAPVARPDGSPRHDPELLAAAYDRIFRMHGRIGPWR
>NZ_CP016824.1|WP_003947462.1|1373598_1374588_-|DNA-binding-protein-WhiA
MAMTAAVKDEVSRLPVTRTCCRKAEVSALLRFAGGLHLVSGRIVIEAELDTAMAARRLKRDILEIFGHSSELIVMAPGGLRRGSRYVVRVVAGGDQLARQTGLVDGRGRPIRGLPPQVVSGATCDAEAAWRGAFLAHGSLTEPGRSSSLEVTCPGPEAALALVGAARRLSIAGKAREVRGVDRVVVRDGDAIGALLTRLGAHESVLAWEERRMRREVRATANRLANFDDANLRRSARAAVAAGARVQRALEILGEEVPEHLAAAGRLRMEHKQASLEELGALADPPLTKDAVAGRIRRLLAMADKRAQDLGIAGTEAGLSEDLADHLVG
>NZ_CP016824.1|WP_003947461.1|1372252_1373260_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MTIRVGINGFGRIGRNYFRALLDQGADIEIVAVNDLGDTATTAHLLKYDTILGKLSEEVSHTEDTITVGDKTVKVLSERNPADIPWGELGVDIVIESTGIFTKKADAEKHLQGGAKKVIISAPAKDEDITIVMGVNEDKYDPATDNIISNASCTTNCVAPMAKVLDENFGIVKGLMTTVHAYTNDQRILDFPHKDLRRARAAAENIIPTTTGAAKATALVLPQLKGKLDGIAMRVPVPTGSVTDLVVELKREVTRDEINAAFEKASQEGQLAGKLVYTADPIVSSDIVSTPASCTFDSLLTMAEGTTAKIIGWYDNEWGYSNRLVDLTVFVGERL
>NZ_CP016824.1|WP_030308389.1|1386776_1387250_-|type-II-3-dehydroquinate-dehydratase
MTRPAHTLATAPIMILNGPNLNLLGQRQPEIYGSETLADVERLCAEEAAALGGTVDLRQSNHEGVLVDWIHEARTGAAGLVINPAAYSHTSVALLDALNACDGLPVIEVHISNIHRREQFRHHSYVSLRADGVIAGCGIQGYAFAVRRIATLLADQS
>NZ_CP016824.1|WP_026235322.1|1387357_1388371_-|TerC-family-protein
MEVSMTLWVLTVVGLIVLIGADFFIGRKPHDVSIKEAGIWTIVWIVLAALFGVGLLIFGGGQQAGEFFAGYITEKSLSVDNLFVFVLIMAKFSVPSQYQQRVLLIGVLIALVLRAIFIAAGAAIIANFSWVFYIFGAFLIYTAWKLIQEARSGDDDEDWEENRLLKAAERRFGVADRYHGTKLFIEKNGKKIMTPMLVVMLAIGTTDLLFALDSIPAIFGLTQDPYIVFTANAFALMGLRQLYFLLGGLLRKLVHLSYGLSVILGFIGVKLVLHALHESGVHVPEISIPVSLGVICAVLVVTTITSLYASRKQAEAEKAGAVTGSGGEDDSRKDSES
>NZ_CP016824.1|WP_067411221.1|1388649_1390503_-|phosphonate-metabolism-protein
MTAELVRGQNQALPWTRLEIGVEADRALALGAVLVGEAGHALGGAEGIALPGAPPPLGLAAPGPPAPTHRLAVDLGALPSAATRLDLFLALPGGPGAPARFGALAAPRVLLLGPGGEKAAGFAVTGLAEETAVVAVELYRRNGAWKIRAVGQGYQGGVPALLTDRGIDPETARRLAAGAQAHPVAPGPAAPRPDPEPVPAGPATPSGGRVDYTHPGRRPAAPAGGHPYATPAPAASAPPAAPAAPVAGDASGWSMEERLHNQVWGMFEDLARTVAAYRGAVEFAEDRRERELDAVLDDPRGRTGQGAADARAAASERYEALVARAQEALDRDLAQLAAESQVVEPALPPALAGWESPVWHAYRSPEQPPLSVRLGDLGLPEAPELRIPMLVRLPLERGLWIDAGRLSDGEGESRPAGLRALAAGSAALHATRLLAVHPPGGLTVHLLDPAGSGAAAFAGLRNAGLLAPAPAAGAAGVAEVLERLTRRVDLVQMAVRGGARDALPPGLDTAEQLLVVHDFPHGFDDRAVTRLRYLADEGPAVGVHLLLVADRDDAAGYGPLLDPLWRGLLRITPLPDRHLADPWVHHLWTFTPPCVPRGSAVLETVVGATARARRPGR
>NZ_CP016824.1|WP_003947474.1|1390655_1391234_-|TerD-family-protein
MTVNLNKGQGISLEKKDGGVLSAVRMGLGWQAAPRRGLFGSRTREIDLDASAVLFADKQPVDVVFFRHLVSDDGSVRHTGDNLVGGAGQGGDDESVLVDLQRVPVHIDQIVFTVNSFTGQTFQEVQNAFCRLVDETNGQELARYTLDGGGQYTAQIMAKVHRADGGWRMTALGTPANGRTFQDLMPSILPLL
>NZ_CP016824.1|WP_067411224.1|1391375_1393523_-|excinuclease-ABC-subunit-UvrB
MRPVSKIERTVAPFEVVSPYQPSGDQPAAIADLDRRVRAGEKDVVLLGATGTGKSATTAWMIEKLQRPTLVMAPNKTLAAQLANEFRELLPNNAVEYFVSYYDYYQPEAYVPQSDTYIEKDSSINEEVERLRHSATNSLLTRRDVVVVASVSCIYGLGTPQEYVDRMVPLKVGEEIDRDALLRRFVEIQYTRNDLAFTRGTFRVRGDTIEIFPVYEELAVRIEMFGDEIETLTTLHPLTGEIISDEQQLYVFPASHYVAGPERMERAVNDIEQELGERLTALEKQGKLLEAQRLRMRTTYDIEMLRQIGSCSGIENYSMHFDGREPGTPPHTLLDYFPEDFLLVIDESHVTVPQIGAMHEGDASRKRTLVDHGFRLPSALDNRPLKWEEFQERVGQTVYLSATPGNYELSRSDGFVEQIIRPTGLVDPEVVVKPTEGQIDDLVHEIRTRTEKDERVLVTTLTKKMAEDLTDYFLELGIQVRYLHSDVDTLRRVELLRELRAGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSGTSLIQTIGRAARNVSGQVHMYADRITPAMEKAIDETNRRREKQIAYNTENGIDPQPLRKKINDIVATIAREDVDTEALLGTGYRQTKDGKAKAPVPDLGGGYDAPKAAKGGKKAAKKAAGTPTDRPAAELAGQIEEMTNRMRAAAADLQFEVAARLRDEVGEMKKELRQMKEAGLA
>NZ_CP016824.1|WP_049978183.1|1393562_1394498_-|hypothetical-protein
MQGTVDGFSYGLVTPVAAYLMACLGGALGLRCTTRSLLVTRTWRPGWLALGTGAIGSGIWTMHFIAMMGFSVTGTPVRYDVPTTFASLGVAIVMVGIGIFVVGYRGATGSALFTGGTVTGLGIASMHYLGMAGMRLNGSLEYSIPLVTASVLIAVAAATASLWAAVQVRGFRWSVGAALLMGVGVSGMHYVGMAAASVHLHPVADTAGDPAGRLIAPLMIGPLLFLLLAGVVVVLDPRMISGAVAPGPPPPPGYRVPVRDSYRLPPAEDRRTVPCPRPERPARSSRDHRTARPPARPAARRRTGPHAGQRR
>NZ_CP016824.1|WP_030767779.1|1394869_1395811_+|glycerophosphodiester-phosphodiesterase
MFARPLSLTAALLMAGTAFVVPTRAATAATPTAQASSGTQASPRFSVRPVAAAPDGGGPTLVAHRGASGYAPENTLAGIDKARELGVRWVENDVQRTKDGVLVVVHDTTLARTTNVEEVFPGRSPWNVKDFTAREIARLDAGSWFGPEFKGAKVPTLDQFLKRMSRQRLSLLLELKAPELYPGIERETLTALRRAGWLDRGHVRDRLVVQSFGADAVRRVHQLRPDVKTGFLGTPAEAELPAYAAFADQINPTHSTVTPSYVDAVQALKGPHGKRLEVYTWTVNDAATARKVRDAGVDGVITNFPDVVKDAIG
>NZ_CP016824.1|WP_067411227.1|1395845_1396406_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MTDDSRDLPVRRADWTVLDTPVGPLLLAATDRGLLQVAFHAQGAVLRRTLTRLAAHLGTDPVEAPEAPSLAAPREQLAGYFAGRTREFRLDLDWSLTEGFTQEALRLLATSVPYGTVTGYGELARRSGRPGGAQAVGMAMGANPLPVVVPCHRVVESDGGLGGFSGGLETKRRLLALEGVLPAPLF
>NZ_CP016824.1|WP_067411230.1|1396455_1397832_+|MFS-transporter
MDIADGLATSPHRPAPPGPEELAALRRRTTGVLVAGQILGGLGVAVGVALSPLLARQVGGTEAVAGLAPTATVAGTALLSVPLAALMTARGRRPGLVLGYLIGAAGAGVVVAGAVLEHFALLLAGMAAFGASSCANLQSRFAAADLAEPGRRARAISLVVWATTIGAVLGPNLAAPAGRSVAGLGVPEAAGPFLWAGVVFLAAALLVAVLLRPDPLLTARALAPEADRTPKGRSFRAAAAAVRTSPQARLALAVIAVSHTVMVSVMSMTPVELGHHGAGIELIGLVISGHIAGMYAFSPLMGRLADRGRLPVIGLCVALLGCAALLAGTAGASHGRTAAGLFVLGLGWSAGLVAGSALLTDAVPQGVRPAVQGLSDLTMNASAGIGGAVAGLVMAGAGYSVLNLLAAALLLPLTALTLFTALTRAPAGESAGHAGGPSGPAQAPASSPEERAAPGSSS
>NZ_CP016824.1|WP_003947481.1|1397777_1398275_-|dioxygenase
MSQTTEPSSAGQRPRLDHLVLWVADPAASAVFYQETLAAQPVRLAEFTAGEVPFPSVRLNDDTILDLMPHTMAPRTEVFPGAHNGSGHPLNHFCVALTGTGFDALAARLERLGAPVSETGRGSFGARGAATRSFYFGDPDGNVIEARHYDEEPGAARSSGEDAGA

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Crispr_ID: NZ_CP016824_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_2

1494619-1494726

Orphan

Consensus_repeat	Method
ACAGCCCGGCCGGCGATTGAGGCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_2

>merge|NZ_CP016824|2|1494619-1494726|CRISPRCasFinder
ACAGCCCGGCCGGCGATTGAGGCCAATCGGTGACCCGCAGGGTCAAGGTGGCACAGGCCGGGGCGGAGCCCAGCCCCAGAAAGACAGCCCGGCCGGCGCTTGAGGCCA

>NZ_CP016824|2|2|1494619-1494726|CRISPRCasFinder
ACAGCCCGGCCGGCGATTGAGGCCA	ATCGGTGACCCGCAGGGTCAAGGTGGCACAGGCCGGGGCGGAGCCCAGCCCCAGAAAG
ACAGCCCGGCCGGCGCTTGAGGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_003947561.1\|1490276_1493825_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|235554
NZ_CP016824.1\|WP_008408550.1\|1504887_1505349_-\|TraR/DksA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224648
NZ_CP016824.1\|WP_067411336.1\|1500120_1500690_-\|dienelactone-hydrolase	unknown	unknown	gnl\|CDD\|223489
NZ_CP016824.1\|WP_079165296.1\|1486579_1487461_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912
NZ_CP016824.1\|WP_003947563.1\|1495722_1496541_+\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|372611
NZ_CP016824.1\|WP_003947551.1\|1480242_1481565_-\|histidinol-dehydrogenase	unknown	unknown	gnl\|CDD\|234853
NZ_CP016824.1\|WP_067411319.1\|1483521_1484559_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067417985.1\|1484570_1485326_+\|LON-peptidase-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366967
NZ_CP016824.1\|WP_067411329.1\|1494938_1495631_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003947568.1\|1502583_1503069_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
NZ_CP016824.1\|WP_010637245.1\|1485876_1486512_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067411334.1\|1498387_1500106_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP016824.1\|WP_067411322.1\|1485345_1485840_+\|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl\|CDD\|237976
NZ_CP016824.1\|WP_008414077.1\|1481791_1483363_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003947567.1\|1500866_1502453_-\|Na+/H+-antiporter	unknown	unknown	gnl\|CDD\|129911
NZ_CP016824.1\|WP_008414084.1\|1487457_1488471_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP016824.1\|WP_067411331.1\|1496667_1498314_+\|alkaline-phosphatase	unknown	unknown	gnl\|CDD\|226070
NZ_CP016824.1\|WP_003947569.1\|1503103_1504048_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP016824.1\|WP_003947570.1\|1504131_1504743_-\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|237810
NZ_CP016824.1\|WP_067417988.1\|1488556_1489777_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350235

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_003947561.1\|1490276_1493825_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|235554	PRK05673, dnaE, DNA polymerase III subunit alpha; Validated.	0
NZ_CP016824.1\|WP_008408550.1\|1504887_1505349_-\|TraR/DksA-family-transcriptional-regulator	gnl\|CDD\|224648	COG1734, DksA, DnaK suppressor protein [Signal transduction mechanisms].	3.02594e-20
NZ_CP016824.1\|WP_003947563.1\|1495722_1496541_+\|thioredoxin-domain-containing-protein	gnl\|CDD\|372611	pfam13462, Thioredoxin_4, Thioredoxin.	7.65538e-32
NZ_CP016824.1\|WP_003947551.1\|1480242_1481565_-\|histidinol-dehydrogenase	gnl\|CDD\|234853	PRK00877, hisD, bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Reviewed.	0
NZ_CP016824.1\|WP_003947570.1\|1504131_1504743_-\|signal-peptidase-II	gnl\|CDD\|237810	PRK14764, PRK14764, lipoprotein signal peptidase; Provisional.	2.07541e-90
NZ_CP016824.1\|WP_067411336.1\|1500120_1500690_-\|dienelactone-hydrolase	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	5.13334e-24
NZ_CP016824.1\|WP_079165296.1\|1486579_1487461_-\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	6.3381e-07
NZ_CP016824.1\|WP_003947568.1\|1502583_1503069_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.1296e-15
NZ_CP016824.1\|WP_067411334.1\|1498387_1500106_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.04704e-94
NZ_CP016824.1\|WP_067411322.1\|1485345_1485840_+\|Cys-tRNA(Pro)-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	7.63963e-73
NZ_CP016824.1\|WP_003947569.1\|1503103_1504048_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	2.43857e-103
NZ_CP016824.1\|WP_003947567.1\|1500866_1502453_-\|Na+/H+-antiporter	gnl\|CDD\|129911	TIGR00831, Putative_Na+/H+_exchanger_Rv2287/MT2345/Mb2309., Na+/H+ antiporter, bacterial form. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds].	9.66702e-79
NZ_CP016824.1\|WP_008414084.1\|1487457_1488471_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.88463e-80
NZ_CP016824.1\|WP_067411331.1\|1496667_1498314_+\|alkaline-phosphatase	gnl\|CDD\|226070	COG3540, PhoD, Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism].	3.29539e-138
NZ_CP016824.1\|WP_067417988.1\|1488556_1489777_-\|NYN-domain-containing-protein	gnl\|CDD\|350235	cd10911, PIN_LabA, PIN domain of Synechococcus elongatus LabA (low-amplitude and bright) and related proteins. This subfamily contains Synechococcus elongatus PCC 7942 LabA which participates in cyanobacterial circadian timing, it is required for negative feedback regulation of the autokinase/autophosphatase KaiC, a central component of the circadian clock system, and appears to be necessary for KaiC-dependent repression of gene expression. This subfamily belongs to the LabA-like domain family which includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Also included in the LabA-like domain family are human ZNF451, uncharacterized Bacillus subtilis YqxD, uncharacterized Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously Pseudomonas putida S16 NicB , which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.12484e-12
NZ_CP016824.1\|WP_067417985.1\|1484570_1485326_+\|LON-peptidase-substrate-binding-domain-containing-protein	gnl\|CDD\|366967	pfam02190, LON_substr_bdg, ATP-dependent protease La (LON) substrate-binding domain. This domain has been shown to be part of the PUA superfamily. This domain represents a general protein and polypeptide interaction domain for the ATP-dependent serine peptidase, LON, Peptidase_S16, pfam05362. ATP-dependent Lon proteases are conserved in all living organisms and catalyze rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins.	1.25978e-35

>NZ_CP016824.1|WP_003947561.1|1490276_1493825_-|DNA-polymerase-III-subunit-alpha
MSATSKPPFTHLHVHTQYSLLDGAARLKDMFDACNEMGMTHIAMSDHGNLHGAYDFFHSAEKAGVTPIIGIEAYVAPESRRTKRKIQWGQPHQKRDDVSGSGGYTHKTIWAANSTGLHNLFRLSSDAYSEGWLQKWPRMDKESISQWSEGLIASTGCPSGEVQTRLRLGQEEEALRAAAEYQEIFGKDRYFLELMDHGIEIERRVRQGLLDIGKKLGIPPLVTNDSHYTYSHESVAHDALLCIQTGKNLSDPDRFRFDGTGYYLKSTEEMYAIDSSDAWQEGCRNTLLVAEQIDTTGMFEKRDLMPKFDIPDGFTEVTWFQEEVRRGMARRFPAGVPEDRQRQAEYEMDVIIQMGFPGYFLVVADFIMWAKNNGIAVGPGRGSAAGSIVAYAMGITDLDPIEHGLIFERFLNPERVSMPDVDIDFDERRRVEVIRYVTEKYGADKVAMIGTYGKIKAKNAIKDSARVLGYPYAMGDRLTKAMPADVLGKGIDLDGITNPKHPRYSEAGEIRGMYENEPDVKKVIDTAKGVEGLVRQMGVHAAGVIMSSEPIVDHAPLWTRHTDGVTITQWDYPQCESLGLLKMDFLGLRNLTIMDDARKMVEANKGIDLDLLALPLDDPKTFELLCRGDTLGVFQFDGGPMRSLLRLMKPDNFEDISAVSALYRPGPMGMNSHTNYALRKNGQQEITPIHPELEEPLKEILGLTYGLIVYQEQVQKAAQIIAGYSLGEADILRRVMGKKKPEELAKNFVLFQEGAKKKGFSDEAIQALWDVLVPFAGYAFNKAHSSAYGLVTYWTAYLKANYPAEYMAALLTSVKDDKDKSAVYLNECRRMKIKVLPPDVNESVHNFAAQSDDVILFGLEAVRNVGTNVVESIIRARKAKGKFSSFPDYLDKIEAQACNKRTTESLIKAGAFDALGHTRKGLTAHYEPMIDNVVAVKRKEAEGQFDLFGGMGDDNADEPGFGLDIEFTDEEWDKTYLLAQEREMLGLYVSDHPLFGLEHVLSDKADAGIGQLTGGDFGDGAVVTVGGIISGLQRKMTKQGNAWAIATVEDLAGSIECMFFPATYQLVSTQLVEDAVVFVKGRLDKREDIPRLVAMELQVPDLSNAGTNAPVIITIPAVKVTPPMVSRLGEVLDSHRGNSEVRIKLQGPRKTTVLRLDRHRVQPDPSLFGDLKVLLGASCLAG
>NZ_CP016824.1|WP_067417988.1|1488556_1489777_-|NYN-domain-containing-protein
MDRCVVLVDAGYLLGAAASLLAGDPSRSRISVDHATLVRQLRERAEAETAQPLLRIYWFDGAPDRVPQPEHRRLRVMPRVTVRLGALTRSDGRWAQKGVDAAMHAELTELARNKACSDIVLVTGDGDLLPGMTAAKEHGVAVHLWAVQAAGGDYNQSEDLVAEADERRLLDRAWITRAIRARDTAGPCAPQPAPGPEIAAILSAPLPDTAARPARDPEPEHTPAPAETNGTGAGAARAVPTPKDLAALRAADRPAPVKEQPATATLRWSSDKGLVERQGPADSPDDAALPTLAHLTTAEQRWADREEDITTVGGDPFEVGQVFARRWLSRLGDRTLLPRLAALYPRIPHRIDGELLRYAARFGLLAHKDDQIDEHDRYAIRAGFWREIDLPATGQPTAGQPLQPAR
>NZ_CP016824.1|WP_008414084.1|1487457_1488471_-|ABC-transporter-ATP-binding-protein
MDRTDPAPAPEGEAVCVVRDLVKTYPATRGRRGAPAVPEVRATDHIDLDVRGGEIFGLLGPNGAGKSTLVRQLTGLMRPDSGSVRLLGHDVVRHPERAARLLAYLGQESTALDELTVSLAAETTARLRGLDAPAARAQRDAVLDELGLGPLASRPLKKLSGGQRRLACFATALVGRRPLLVLDEPTTGMDPVARRAVWAAVDRRRAEEGTTVLLVTHNVIEAETVLDRVAVLEQGRVIACDTPSGLKAHVAHEVRLDLLWRERPPLDVPEVAALRDSAAESGRRWVLRLAPDEARAAVAAVTGGSAFAALDDFTLATPSLEDVYLALGGSGTGLVKT
>NZ_CP016824.1|WP_079165296.1|1486579_1487461_-|ABC-transporter-permease
MTGGPATPTTDRRAPAPGRAAHGTGPGMSTTARTAAPRAVAAPAALAPRARLLPALAAVYRAQLSRARVARIPLLFVATFQSVGIMILMRGVVDGGTEAHAVVAGSSVLVVAFVALNLLAQYFGQLRAGGGLDHYATLPVPPAAVVLGAAGAYASFTVPGTLVTALVGCVLFQLPLAQLWVLIAVIPLAGAALSGLGAALGLLAPRPELATLLGQLGMSAALLLGVLPPERLPALLVLARDLLPSTYGVEAFARTFAPHPDWAAVLVDLGVCGGVGVVSLTLATWAYRRAAVR
>NZ_CP016824.1|WP_010637245.1|1485876_1486512_-|hypothetical-protein
MTAPLNPPPPPHGRPGYDPWQLPEGAHPDHPRGTERDEPLGREIRRAALTGLAVVVLGLLLGFLWSRLAPHVPLVSDGEAVYLKDTEGEQAIGADGTFALLALGFGAVTGLAAFLVHRAGGIAMVCGLALGSLGGAAVAWQLGMALGPSGDVVGHARTAGQGVTFDAPLELGALGVLVAWPIAALLVHLGLTALFGPREEPRAHHWQTYEG
>NZ_CP016824.1|WP_067411322.1|1485345_1485840_+|Cys-tRNA(Pro)-deacylase
MAKKQKKQSGGTPATVALTAAGAAFTTHAYEHDPAHPSYGEEAAEAMGVSPDRVFKTLVAEVDGRLTVAVAPVSGSLDLKALATAAGGKKAAMADPAAAERTTGYVRGGISPLGQRKALPTVLDASATGHATICVSAGRRGLEVELAPAVLAELTGAVTAPIAR
>NZ_CP016824.1|WP_067417985.1|1484570_1485326_+|LON-peptidase-substrate-binding-domain-containing-protein
MTTVRLPLFPLNTVLFPGLVLPLNVFETRYRAMMRDLLDSLPEDPESDEPCQFVVVAIRDGHEVAPSEPGMPDDAGRPEAGPMTGFGDDPARSLHAVGCVADAATIREREDGGYEVLATGTTRVRLHSIDTSGPYLTAEAEELPEDPGDEAGALAEGVLRAFRSYQKRLAGARELTLTSNADLPDEPSVVSYLVAAATVLDVPTRQRLLQPPDTASRLRDELALLRRETAVIRHLPSLPAAELTRTPTSLN
>NZ_CP016824.1|WP_067411319.1|1483521_1484559_+|hypothetical-protein
MVGTMALLQALIRTARMVTHTTRLATGLPPDEEVYLDLPDDRLAPALAAAGLGDHRPAAEVLAASREAAAWETRDRQVQRLAAFARNRPEWFDAWSYAAPHDPDVALIRAELAVRRGWESPARAELLHDVTPLIAAAARAEPADPVPWRIALDHARGTGAPHTEFEARWEQAVRRSSYHYGCHVAALQYLSAAWFGSHRESFAFAERAAEDALPGSLVRGLPVRAAFGALHRAPDAPGRGGPVLRERLDAAADTAIALSAEYPAGDPWPAEVRNVLFYVLIRLERWADALEQARLIGTRATSFPWDRISDDPLGQFLQARDGVRIEVAASLPLRGTRRREKAGDH
>NZ_CP016824.1|WP_008414077.1|1481791_1483363_+|hypothetical-protein
MSTEQGGEPPEGLTATEYGMWQAFRNGSTYDLRAGEAALDDPHGGLPWGEERSVRARVVSLLLLHGPDPLPGRVSSLKLAGVQITDVLDLAGGTVEPYVELIGCRFEKEVLLPEARFTTLRLVDCSLPRLEAARVSTEGDLHLPRCRVHRGVRLTDAQIGTDLLLNQAVVHRDRRGTSLLGDGLSVGQDFQAEMMEAHGEVSLRGAQIGVSLSLRGSRLANPYGRRALNAPQLTVGRTLYLTPAGVGNPTLTSGTTPARGTRVQRFECRGGVRLDDGRVGDAVDLDQARFVMEEYQELSLRRVQTPELRFLCERPAQGRVVLSGAKVGNLMDQTPSWPGPGGLAMGGFTYDNLVPRGRFTLAERLTWVEAATPEYNPEPYELLAAVLRAGGEDADAREVLLAKQRRRRETLGLAGTVWGYLQDWTVAYGYRPGRAALWMAVLWAVSALLFAQIDPAPIKDDEHPPWSSSLFTLDLLLPVIDLGQTGYWHLDGGWQWVTALLILLGWILATTVAAGATRLLRRG
>NZ_CP016824.1|WP_003947551.1|1480242_1481565_-|histidinol-dehydrogenase
MISRIDLRGEALPEGPALRALLPRADFDVTAALEKVRPICEDVHHRGDAALIEYARRFDQVTLEQVRVPAEALAEALAGLTDEVRAALEESIRRARTVHRAQRRTPHTTQVVPGGTVTEKWVPVDRVGLYAPGGRSVYPSSVIMNAVPAQEAGVPSIALASPPQAEFGGLPHPTILAACALLGIDEVYAVGGATAVAMFAYGTESCPPARMVTGPGNIWVAAAKRYFTGLIGIDTEAGPTEIAVLADDTADPVHVAADLISQAEHDPLAAAVLVTDSDALADAVEKELAVQVPATRHVEDRIAPALAGRQSALVLVADLEDGLKVVDAYGAEHLEIQTADATAVADRVRNAGAVFVGPWAPVSLGDYCAGSNHVLPTGGCACHSSGLSVQSFLRGIHIVDYSRDALADVAHHVVTLAEAEDLPAHGAAVKARFDWKVPQQ
>NZ_CP016824.1|WP_067411329.1|1494938_1495631_+|hypothetical-protein
MDTPIAETAPRALRAALFTVLAVTLSTTSHVLLSGAPLPLPTVALVGATVFALAWSLAARERGFGRIAALLVPLELAADTVFTAGQHVCYGATGGPVAGPLRTVGVDLLCGGGALGAPLARLLGAPAESPAAFTAHPRPELAWLLLGAHVGVGLLAAAWLRYGERALAQLLRAAAAQAFRPLALAVARVPAPHAPRTARPRPEAAPAGRPALLIAHSVGRRGPPAGLLPA
>NZ_CP016824.1|WP_003947563.1|1495722_1496541_+|thioredoxin-domain-containing-protein
MSKRNSQAAKSAARERLRIEREKQAKKDKARRQLIVAGSVVGVLAIAGGVGFAVVKANEPGYWEKAADQKLVKPANTSGAQGTTVVIGKDDAAKTLKIYEDPRCPVCASFEQNVGETIDQDLKDGKYKLQFVGASFLDRGLGGEGSKNALSALGAALNVSDEAFMAYKSALFSAENHPEESKDEFAKDGKLIEIANQVPELKGNSAFKKDVENGTYDKWALEMSKVFDDNKDGVEGTPSLVMDGKKVTAEGSDNAPQTPEQFNAAVDKALKG
>NZ_CP016824.1|WP_067411331.1|1496667_1498314_+|alkaline-phosphatase
MTSRTEHHPRPAAPSRRTVVLAAAATGALLPLGAATTATAAATPRFLHGVASGDPLPDGVLLWTRVTPTEEAQPGSGAGPDTEVGWEIAADAAFSSVVARGTVTARAATDHTVKADVRGLSPATGYWFRFTAGSTVSPTGRTRTAPAASASPAGLRFGVVSCANWEAGWFSVYRHLAARGDLDAVLHLGDYIYEYATGDYPATPVRPHRPAHEITTLADYRLRHATYKTDPDLAALHARHPVIAIWDDHEFANDAWSGGAENHTPGAEGAWSERSAAARQAYFEWMPVRASTEGTVFRRLRFGDLADLHLLDLRSFRSEQVSIGNGAVDSPDRSITGRAQLDWLKAGLSGSQAAWQLVGTSVMISPVAFGSVPAHLLKPLAELLGLPTQGLAINVDQWDGYTADRTELIRHLRSAGIRDTVFLTGDIHMAWANDVPVTAATYPLSESAATEFVVTSVTSDNLDDLLKVAPGTLSTVAEGAIKAANRHVKWLDMDGHGFGVLDVTAERSQMDYYLLSDRADPGATASWLRSYRTRRGTQRVERADAPVA
>NZ_CP016824.1|WP_067411334.1|1498387_1500106_+|serine/threonine-protein-kinase
MFRQGAVTARRRLYTLGPMSAPGEMIGGRFTLLAPLGSGGMGTVWRARDEVLHREVALKEVRPPDPAMTGPEAAATLRERVLREARALARLSHPHVVTIHQIVDAGAGTHPWIVMELVPGESLADRLQRGPLLPQEAATLGRQLLAALRSAHAAGIHHRDVKPANILLRTDPGVPGPPSAVLTDFGIAALQGSTALTATGGLIGSPEYIAPERVRGRDDHPASDLWSLGLVLYVAVGGHSPLRRATTLATLAAVLDEPVPPPVRSGPLAAVLGALLVRDPEARPDAATLDRLLTEAASGSAPSWAEPTVSGPRPVPAAPVTPPPPGPPTPPPGAPAAGTPAPAPYRPPLPTPTTAVARPRRRTGALVAGAAALVAVAVTATVLVLNPWKSDNHAAPSPSPSPTATRSPDGEKDPKPSPDTGSTGTDPVDEDKNGDGEEDQEKEDDRPGQDDSPSPSATPQPPSGGSWIAQLFSEPVSTGTATRDRRLAAVRAEVPEARYLRSDDYASLRPGYWVFYVPGPFDDGRAALRFCAEKGRTSGNECVGRYLSDDGADADAICHPPAASPKGRCTRS
>NZ_CP016824.1|WP_067411336.1|1500120_1500690_-|dienelactone-hydrolase
MEILLIHSVYGVRPALEQAAGRLREAGHEVHVPDLFEGLSPADMEEGLALRDEIGTDELLKRAVRAAAPYSDKGLVYAGFSLGGAIAQNLALADEKARGLVLFSGTSDLPDDASAEDLPVQLHVTENDPFEPHDWLNAWYLRMQRAGADVEVYRYPGAGHLYTDPDLPDYDAEAAEATWRTVQGFLDSL
>NZ_CP016824.1|WP_003947567.1|1500866_1502453_-|Na+/H+-antiporter
MDQLALLLLLLLGAVITVPLGDRLGLPAPVLMTLGGIVLALLPFVPNVNVPPEYILPLVLPPLLYAAVQRTSWRQFTANYRPILLLAVALVFVTTAAVAGVANAIVPGLPLAAAVALGALVAPPDPVAATAVAGQLGLPRRLVSVLEGEGLFNDVTAIVLYHVAIAAAVTGTFSWGGAVGQFFLSAAVAVAVGLALGWVSKKMMSMLGDATLQTGLTLLVPFASYILAEELHGSGVLAVLTTALLLAGTALDADDVLGRITGQTFWHVVDTLVTGIAFGLIGLELHTVIRAAEGREGQMIGWGVAIVAVVVGVRLLWLLPTTWLAQKMHSLRDENEEIPTSWRETVVMWWSGMRGVASVALALAIPLTTDDGKPFPARDEIIFIAFCVIMATLLVQGLTLPWLVRKLGVTADTDAEHKLEHDLAIRAAKAARRRLKEIEATEELPEDISERLQRGALDIGVRISPDLLDDERREWWVQRAERVAAMSRVQREMMSAARREVLSARNEPGADPEVVDRVLRQLDVRSLR
>NZ_CP016824.1|WP_003947568.1|1502583_1503069_-|GNAT-family-N-acetyltransferase
MSQPTPADVRVRVAEGPADREACFAVRKEVFVAEQGVDEAIEYDAFDAPESDTVHVLAEGPDGPLGTGRLLHGPAAAGATGGEPGVGSLGRLAVRQAARGLGVGAALVRGLEGAAAQLGLRAVDLHAQTHALGFYERLGYQAYGPEFEDAGIGHRAMRREL
>NZ_CP016824.1|WP_003947569.1|1503103_1504048_-|RluA-family-pseudouridine-synthase
MSTIPEIRTLPVPDGLEGERVDAAISRMFGFSRTKAAELAAAGKVLVDGAAVGKSERVHGGAWLEVEMPAAPAPVQIVAEPVEGMEIVHDDDDIVVIVKPVGVAAHPSPGWTGTTVIGGLAAAGYRISTSGAAERQGIVHRLDVGTSGLMVVAKSERAYTLLKQQFRERTVDKRYHALVQGHPDPMSGTIDAPIGRHPQHDYKWAVTAEGKPSVTHYDLIEAYRAASLLDIKLETGRTHQIRVHMSAHRHPCVGDLTYGADPTLAKRLGLTRQWLHAVRLGFEHPADGSWAEFSSEYPADLQHALDTVRAESNA
>NZ_CP016824.1|WP_003947570.1|1504131_1504743_-|signal-peptidase-II
MAEAERIIGMPETPEAREPDRAEPPEPGGDEQEGGATAAAPRGPRRVAVLFTVAVVAYLLDLGSKLLVVAKLEHHAPIQVLGDWFELRVIRNAGAAFGFGEAFTIIFTVIAASVIVVIARLARKLYSLPWALALGLLLGGALGNLTDRIFRAPGVLEGAVVDFLAPKNFAVFNLADSAIVCGGILIVILSFRGLDPDGTVHKD
>NZ_CP016824.1|WP_008408550.1|1504887_1505349_-|TraR/DksA-family-transcriptional-regulator
MVAKKTGTAEKSGPVPQARAGAEALAVRPGEDPWTEAEAEEARAGLRADAERIRTEIDASGQALAGLMRDSGGGAGDDEADTGTKNITREHELSLAANAREMLRQTEQALVRLDEGTYGTCENCGNPIGKARLQAFPRATLCVDCKQKQERRG

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Crispr_ID: NZ_CP016824_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_3

1554090-1554234

Orphan

Consensus_repeat	Method
AGCCCGGCCGGCGTTTGAGGCCA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP016824_3

>merge|NZ_CP016824|3|1554090-1554234|CRISPRCasFinder
AGCCCGGCCGGCGTCTGAGGCCACAGTTCAAGCCCGGCCGGCGTCTGAGGCCACAGTTCAAGCCCGGCCGGCGTTTGAGGCCATCTTTGACCGGCACGGTCCGGACGAAGCGGACCCACATCAGCCCGGCCGGCGCTTGAGGCCA

>NZ_CP016824|3|3|1554090-1554234|CRISPRCasFinder
AGCCCGGCCGGCGTCTGAGGCCA	CAGTTCAAGCCCGGCCGGCGTCTGAGGCCACAGTTCA
AGCCCGGCCGGCGTTTGAGGCCA	TCTTTGACCGGCACGGTCCGGACGAAGCGGACCCACATC
AGCCCGGCCGGCGCTTGAGGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_033239469.1\|1552355_1552988_-\|sulfite-oxidase-like-oxidoreductase	unknown	unknown	gnl\|CDD\|239027
NZ_CP016824.1\|WP_030768985.1\|1548311_1548548_+\|sulfur-carrier-protein-ThiS	unknown	unknown	gnl\|CDD\|273754
NZ_CP016824.1\|WP_079165300.1\|1555946_1557878_+\|phenazine-specific-anthranilate-synthase	unknown	unknown	gnl\|CDD\|223225
NZ_CP016824.1\|WP_008410429.1\|1553135_1553615_+\|bacterioferritin	unknown	unknown	gnl\|CDD\|153099
NZ_CP016824.1\|WP_067411397.1\|1549519_1551394_+\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP016824.1\|WP_003947617.1\|1561023_1561812_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP016824.1\|WP_067418000.1\|1558987_1559659_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP016824.1\|WP_067411394.1\|1547088_1548315_+\|glycine-oxidase-ThiO	unknown	unknown	gnl\|CDD\|274092
NZ_CP016824.1\|WP_067411399.1\|1551461_1552328_+\|deoxyribonuclease-IV	unknown	unknown	gnl\|CDD\|214707
NZ_CP016824.1\|WP_067411409.1\|1559697_1560906_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP016824.1\|WP_106428967.1\|1555725_1555851_+\|trp-operon-leader-peptide	unknown	unknown	unknown
NZ_CP016824.1\|WP_067411391.1\|1545614_1546802_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|369639
NZ_CP016824.1\|WP_003947621.1\|1564532_1565474_-\|ROK-family-glucokinase	unknown	unknown	gnl\|CDD\|273246
NZ_CP016824.1\|WP_003947612.1\|1554321_1555674_-\|3-deoxy-7-phosphoheptulonate-synthase-class-II	unknown	unknown	gnl\|CDD\|366662
NZ_CP016824.1\|WP_003947606.1\|1548550_1549345_+\|thiazole-synthase	unknown	unknown	gnl\|CDD\|234687
NZ_CP016824.1\|WP_003947619.1\|1562819_1563434_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067418003.1\|1563464_1564247_-\|endonuclease	unknown	unknown	gnl\|CDD\|226098
NZ_CP016824.1\|WP_003947618.1\|1562038_1562827_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224561
NZ_CP016824.1\|WP_008410462.1\|1544111_1544477_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375793
NZ_CP016824.1\|WP_079165299.1\|1553634_1553874_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|377304

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_033239469.1\|1552355_1552988_-\|sulfite-oxidase-like-oxidoreductase	gnl\|CDD\|239027	cd02109, arch_bact_SO_family_Moco, bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate. The specific function of this subgroup is unknown.	1.32772e-92
NZ_CP016824.1\|WP_030768985.1\|1548311_1548548_+\|sulfur-carrier-protein-ThiS	gnl\|CDD\|273754	TIGR01683, thiamine_biosynthesis_protein_ThiS, thiamine biosynthesis protein ThiS. This model represents ThiS, a small, ubiquitin-like thiamine biosynthesis protein related to MoaD, a molybdenum cofactor biosynthesis protein. Both proteins are involved in sulfur transfer. ThiS has a conserved Gly-Gly C-terminus that is modified, in reactions requiring ThiI, ThiF, IscS, and a sulfur atom from Cys, into the thiocarboxylate that provides the sulfur for thiazole biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine].	8.67674e-21
NZ_CP016824.1\|WP_079165300.1\|1555946_1557878_+\|phenazine-specific-anthranilate-synthase	gnl\|CDD\|223225	COG0147, TrpE, Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism].	7.22982e-54
NZ_CP016824.1\|WP_008410429.1\|1553135_1553615_+\|bacterioferritin	gnl\|CDD\|153099	cd00907, Bacterioferritin, Bacterioferritin, ferritin-like diiron-binding domain. Bacterioferritins, also known as cytochrome b1, are members of a broad superfamily of ferritin-like diiron-carboxylate proteins. Similar to ferritin in architecture, Bfr forms an oligomer of 24 subunits that assembles to form a hollow sphere with 432 symmetry. Up to 12 heme cofactor groups (iron protoporphyrin IX or coproporphyrin III) are bound between dimer pairs. The role of the heme is unknown, although it may be involved in mediating iron-core reduction and iron release. Each subunit is composed of a four-helix bundle which carries a diiron ferroxidase center; it is here that initial oxidation of ferrous iron by molecular oxygen occurs, facilitating the detoxification of iron, protection against dioxygen and radical products, and storage of ferric-hydroxyphosphate at the core. Some bacterioferritins are composed of two subunit types, one conferring heme-binding ability (alpha) and the other (beta) bestowing ferroxidase activity.	1.27534e-71
NZ_CP016824.1\|WP_067411397.1\|1549519_1551394_+\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.34668e-111
NZ_CP016824.1\|WP_003947617.1\|1561023_1561812_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	2.50788e-48
NZ_CP016824.1\|WP_067418000.1\|1558987_1559659_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.24755e-58
NZ_CP016824.1\|WP_067411394.1\|1547088_1548315_+\|glycine-oxidase-ThiO	gnl\|CDD\|274092	TIGR02352, Glycine_oxidase, glycine oxidase ThiO. This family consists of the homotetrameric, FAD-dependent glycine oxidase ThiO, from species such as Bacillus subtilis that use glycine in thiamine biosynthesis. In general, members of this family will not be found in species such as E. coli that instead use tyrosine and the ThiH protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine].	3.25761e-117
NZ_CP016824.1\|WP_067411399.1\|1551461_1552328_+\|deoxyribonuclease-IV	gnl\|CDD\|214707	smart00518, AP2Ec, AP endonuclease family 2. These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites.	8.093e-94
NZ_CP016824.1\|WP_067411409.1\|1559697_1560906_-\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.5522e-20
NZ_CP016824.1\|WP_067411391.1\|1545614_1546802_-\|oxidoreductase	gnl\|CDD\|369639	pfam07992, Pyr_redox_2, Pyridine nucleotide-disulphide oxidoreductase. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.	5.18928e-59
NZ_CP016824.1\|WP_003947621.1\|1564532_1565474_-\|ROK-family-glucokinase	gnl\|CDD\|273246	TIGR00744, Glucokinase_Glucose_kinase., ROK family protein (putative glucokinase). This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General].	6.22919e-142
NZ_CP016824.1\|WP_003947612.1\|1554321_1555674_-\|3-deoxy-7-phosphoheptulonate-synthase-class-II	gnl\|CDD\|366662	pfam01474, DAHP_synth_2, Class-II DAHP synthetase family. Members of this family are aldolase enzymes that catalyze the first step of the shikimate pathway.	0
NZ_CP016824.1\|WP_003947606.1\|1548550_1549345_+\|thiazole-synthase	gnl\|CDD\|234687	PRK00208, thiG, thiazole synthase; Reviewed.	6.99448e-152
NZ_CP016824.1\|WP_067418003.1\|1563464_1564247_-\|endonuclease	gnl\|CDD\|226098	COG3568, ElsH, Metal-dependent hydrolase [General function prediction only].	6.0088e-14
NZ_CP016824.1\|WP_003947618.1\|1562038_1562827_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	3.0306e-36
NZ_CP016824.1\|WP_008410462.1\|1544111_1544477_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375793	pfam18367, Rv2175c_C, Rv2175c C-terminal domain of unknown function. This is the C-terminal domain of unknown function found in actinomycetes such as M. tuberculosis Rv2175c. Rv2175c has a DNA binding activity and possesses a winged helix-turn-helix fold, furthermore it is identified as a substrate of the PknL kinase.	5.61182e-30
NZ_CP016824.1\|WP_079165299.1\|1553634_1553874_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|377304	pfam04324, Fer2_BFD, BFD-like [2Fe-2S] binding domain. The two Fe ions are each coordinated by two conserved cysteine residues. This domain occurs alone in small proteins such as Bacterioferritin-associated ferredoxin (BFD). The function of BFD is not known, but it may may be a general redox and/or regulatory component involved in the iron storage or mobilisation functions of bacterioferritin in bacteria. This domain is also found in nitrate reductase proteins in association with Nitrite and sulphite reductase 4Fe-4S domain (pfam01077), Nitrite/Sulfite reductase ferredoxin-like half domain (pfam03460) and Pyridine nucleotide-disulphide oxidoreductase (pfam00070). It is also found in NifU nitrogen fixation proteins, in association with NifU-like N terminal domain (pfam01592) and NifU-like domain (pfam01106).	3.10678e-10

>NZ_CP016824.1|WP_079165299.1|1553634_1553874_-|(2Fe-2S)-binding-protein
MNRVYVCSCFGITEEEVRARAAAGAGTPRSIASACKAGTDCGSCVRRIQALLGRGATPRRHAAGCRAVAGSAAPLDEAA
>NZ_CP016824.1|WP_008410429.1|1553135_1553615_+|bacterioferritin
MQGDPEVIEFLNEQLTAELTAINQYWLHYRIQDNNGWYKLAKYTRAESMDEMKHADKLTERILFLDALPNYQRLFHVRVGQTVTEMFEADMQIELEAVDRLKRGIEVMRSKGDHTSRRLFEEILEDEEHHIDYLEAQLAIIEKMGEALYIAQQIEQPDS
>NZ_CP016824.1|WP_033239469.1|1552355_1552988_-|sulfite-oxidase-like-oxidoreductase
MEGMGQPESREAQQPQLPPGQRLQRGWPVTHYGPVPRFRPDRWEFRVFGATAEQGKHTWTHDEFTALPYTTVVADLHCVTKFSMLDAEWGGVLARTVAEAAPPAGHVTHVMVWAEYGFSSNLRLSDFLDERTVFATHKDGELLTAEHGFPLRLIVPHLYAWKGPKWVRGIEYMTADRRGFWEERGYHNVGDPWREQRYSYQEEPGDGPGL
>NZ_CP016824.1|WP_067411399.1|1551461_1552328_+|deoxyribonuclease-IV
MNKSSIGAHIPVAGGLAKTGLAYAQDLAAEAVQVFVANPRGWATPAGDPKQDKEFRRLCAEREIPAYVHAPYLINFGSHTEATAAKSVDSLRHSLRRGREIGALGVVVHTGSATGGRPRETALAQARELMLPLLDELGDEDPYLLLESTAGQGASLCAEVADFGPYFDVLERHPKLGVCLDTCHIHAAGHDLAAPGGVKETLDALVATVGEGRLRLIHANDSKDVAGAHKDRHESIGSGSIGADPFGELLGHPAVAGVPLVIETPGGKEGHTADVARLKELRDAAQGG
>NZ_CP016824.1|WP_067411397.1|1549519_1551394_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MLDGRYRVDALIAVGGMATVYRALDTRLDRVVALKVMHPELAADASFVERFIREARSVARLSHPNVVGVFDQGAEGAYVYLAMEYVPGCTLRDVLRERGALTPRAALDVLEPVLAALGAAHRAGFVHRDMKPENVLIGDDGRVKVADFGLVKAVDTVTNTTGAVLGTVSYLAPEQIEQDDVADARVDVYACGVVLYEMLTGGRPHSGDSPAQVLYRHLNEDVPPPSAAVPHLGPELDRLVAVATSRAPEGRPEDAVALLALARDARAALDDAALDAVPPAALEGDRSIAEDRTSVIPRFSTPARPADDDGVQRTSVLAAAPPEPPAPRRRLGNRRKGGLAALVAVLLVLCVGAGVWYINSGQFTRVPPLLAKTEDEARQRLADAGLKVGGVDKAYSDTADRGTVTKTDPGTGERVRGNGSVDLTVSLGPRKVTVPRVGGMALDKAKARLRDAGLEPGMVTRAFSDSVAKGEVVSTDPSAGTERRGGSAVALVVSKGAPVEVPDVAGSSLQEATEALKEAGLKVSTADERVFSEHEKGAVAAQSPKPGTELAEGGEVELTLSKGPDLVEVPDVTGQKEDEARKTLEGAGFKVDVSRWFFGDTVWDQSVEGGETAPRGSEITIRVR
>NZ_CP016824.1|WP_003947606.1|1548550_1549345_+|thiazole-synthase
MADDTFTIGGTEFGSRLIMGTGGAPSLEVLERALTASGTTLTTVAMRRLDPGVAGSVLSVLERLAIQVLPNTAGCYTAGEAVLTARLAREALGTDLVKLEVIADERTLLPDPVETLEAAEVLVDDGFTVLPYTNDDPVVARRLEEAGCAAVMPLGSPIGSGLGIRNPHNFELIVERAQVPVILDAGAGTASDAALAMELGCAGVMLASAVTRAQEPELMASAMRHAVEAGRLAYRAGRIPRRHFARASSPVEGVARLDPERPAF
>NZ_CP016824.1|WP_030768985.1|1548311_1548548_+|sulfur-carrier-protein-ThiS
MTAEGTRSEVGTYAVSVNGERRELAAGTTLEALVAELTSAPRGVAAAVNEAVVPRGAWTATVLGEGDRVEVLTAVQGG
>NZ_CP016824.1|WP_067411394.1|1547088_1548315_+|glycine-oxidase-ThiO
MGPEAVPAAEPAPATAAYAAGGARDVVVAGGGIVGLVTAWRAAQRGLAVTVVDPAPGGGAAQVAAGMLAAVTELHFGEERLLALNLASAERYPAFAAELAEASGQELGYRRCGTLAVALDADDRAYLRELHALQLRSGLESEWLSGRECRRLEPMLAPGVRGGLRVDGDHQIDPRRLASALVTACERAGVVWCRSTAGRLVVRGGRAAGVELADGSLVEGGQTVLAAGSRSGLLAGLPEEVAVPVRPVKGQVVRLAVPEAYRRGAAFLSRTVRAVVRGSHVYLVPRENGELVIGATTEELGWDTTVTAGGVYELLRDAHELVPGLTELPFTEVRAGLRPGSPDNAPLLGPTALPGLHLATGHHRNGVLLTPVTGDVLADVLTTGELPGYADAFTARRFEAAPVQEGAR
>NZ_CP016824.1|WP_067411391.1|1545614_1546802_-|oxidoreductase
MVVVGAGMAGVQTAVALREQGYEGPVTLLGAEPHPPYDRPPLSKAVLLGTAEGSAFDVDFEGLGIGLRLGVAVTGVRPAAHLVDTDAGPVPYTALVLATGAEPLALPGTQDHPAVHLLRTLDDATRLRPVLADRRTVVVVGAGWIGAEFATAAREAGCHVTVVEAAERPLAGALPAEAAEPMTAWYAEQGVELLTGVAVSRVEDHGVRLADGRLLPADAVVVGIGARPATGFLAGSGIALDAHGAVLADGLLRASVPDVYAVGDCASFPSARYGRRLLVHHWDNALQGPRTVAAALTGQEPAPYDPVPYFWSEQFGRFVQYAGHHAPEDLLVHRGDPHAAAWSLCWLSPAGALRAVLTVGRPRDLTQGRKLIASGAPLAPPRVADPPVPLKSTTA
>NZ_CP016824.1|WP_008410462.1|1544111_1544477_-|helix-turn-helix-domain-containing-protein
MTEIDAKIDALVPEWLTLPDIAEQLDVEVTRVRQLVKDGQLLAVRRGENRVLMVPAAFIDGDKVVKGLSGLLTVLRDDGFADDEMLEWLFTPDETLPGTPAQALNENRGTEVKRRAQALAV
>NZ_CP016824.1|WP_003947612.1|1554321_1555674_-|3-deoxy-7-phosphoheptulonate-synthase-class-II
MTSTVENSAARVPSWRTLPAAQQPEYPDQEALARVVTELESFPPLVFAGECDQLRARLGAVARGEAFLLQGGDCAESFDGVGADDIRAKVKTLLQMGAVLTYAASVPVVKVGRIAGQYSKPRSKPTETRDGVTLPTYRGDSVNGFDFTEAARVPDPERLKRMYHASASTLNLVRAFTTGGYADLRQVHAWNQDFVKSSPSGQRYEKLAREIDNAMSFMRACGAEPEEFRTVEFYASHEALLLDYETALTRTDSRTGHLYDVSGHMVWIGERTRQMDGAHIEFASKVRNPIGIKLGPTTTPEEALEYIERLDPEREPGRLTFIVRMGADKIRDRLPTLVEKVTASGAQPVWVTDPMHGNTFEAASGHKTRRFDDVLDEVKGFFEVHKELGTHPGGIHVELTGDDVTECVGGGDEIFVDDLHQRYETACDPRLNRSQSLDLAFLVAEMYRGQ
>NZ_CP016824.1|WP_106428967.1|1555725_1555851_+|trp-operon-leader-peptide
MGRATHCHASAPGGGGGCATIRPMTAQQTQNWWWTAHPAAR
>NZ_CP016824.1|WP_079165300.1|1555946_1557878_+|phenazine-specific-anthranilate-synthase
MSPTSPTPPEAPFDLARLTAPGAPPFALLRRSAPGLDGRTVEVLTGPVREVDHLADLPVDERPALALVPFRQIRERGFDVRDDATGLVVLHADAVHRMPVEEALAALPAHPVEVADGGFDLGDGAYEEVVRRVVADEIGGGEGANFVISRTWEGRIEGYAPADALALFRRLLDQERGAYWTYVVHTGERTLVGASPEVHVRMSGGGRDEAGGTVVMNPISGTYRYPAEGPTAQGLLDFLDDAKERDELSMVVDEELKMMCAVGDLGGVVVGPRLKEMAHLAHTEYELRGRSTLDVREVLRQTMFAATVTGSPVQNACRVIERYEPGGRGYYAGALALLSADASGAQSLDSPILIRTADVDAAGLVKVRVGATLVRGSDPAGEVAETHAKAAGVLAALGVRPARPKAGPAPVRFADDIRVRAALDARRERLSPFWLRMREPVAPVAGEALVVDAEDTFTSMLAHVLRAAGHRTTVRRFDEPGLREAVAAHRGAVVLGPGPGDPSDPADPRMRLLREVTAEVLDARHGGRGVLGVCLGHELIAAELGLPLVRKRVPYQGAQVAIDLFGRWETVGFYNSYVASCDDEAATELAAHGVEVSRDAAGEVHALRGPGFASVQFHPESVLSLRGPALVAELLAGVPVQAG
>NZ_CP016824.1|WP_067418000.1|1558987_1559659_-|response-regulator-transcription-factor
MVVDDHPMWRDAVARDLAEAGFAVVATAGDGPQAVRRARATRPDVLVLDLNLPGLPGARVCQEVAGEDGPPVLVLSASGEHTDVLEAVKAGATGYLVKSAGTEELIDAVHRTARGDAVFTPGLAGLVLGEYRRLAAGPAPTRGKPDAPRLTARETEVLRLVAKGLSYKQIAERLVISHRTVQNHVQNTLGKLQLHNRVELVRYAIEAGLDEEDEAEGTPGAER
>NZ_CP016824.1|WP_067411409.1|1559697_1560906_-|histidine-kinase
MSVEQPLWRALTAYRALTAVYAVAIAVVARDSYERPQVAFGYLAVLLVWTLATLPRFTGAARCTRPFLAVDTGLALAGILLTPLADGAGRHAADGPTLPSIWTAGAVLACALKGGWRWAAAASTLVGAANLAQRGEASPNTLHNVLLVWVAAIAIGYVVEVARASERTLARALEIQAATRERERLARDIHDGVLQVLAMVQRRGTAVGGEAAELGRLAGEQEAALRRLITQGPVPEPRTAAGPDAAPEDDTRPQDLMALLGRYADARVTLSGPGTPVELAPHAARETAAAVGAALDNVRTHVGPRARAWVLVEDEPDQVLVSVRDEGPGIPEGRLAEAAEEGRLGVAQSIRGRLRDLGGTAELVSVPGQGTEVELTVPKQDEGGGGAATGRRYPARTGGGTQ
>NZ_CP016824.1|WP_003947617.1|1561023_1561812_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MIYGAMKVVIGGPLKVAFRPWVEGIENIPADGPAILASNHLSFSDSFFLPTMLDRKVTFIAKAEYFTTPGVKGRMTAAFFKGVGQLPVDRSGGRGAGEAAIRSGIEVLERGELFGIYPEGTRSPDGRLYRGKPGGLARVALATGAPVIPVAMIDTEKIQPPGQVRPKLMRPGIRIGKPLDFRRYEGMDHDRFVLRAVTDEVMYEIMKLSGQEYVDVYATVAKRQMAEDAKKRAEEEKAIAKAEKAAAKAATAREQDDSGRAA
>NZ_CP016824.1|WP_003947618.1|1562038_1562827_+|alpha/beta-fold-hydrolase
MPVLPGAEPYRHDGGPTGVLLCHGFTGTPQSMRPWAEDLAARGHTVSLPLLPGHGTRWEDLQLTGWQDWYAEVDRALGELLARCERVYVAGLSMGGALALRLAARHGDAVRGVVVVNPANKVHGLSAYALPAARHLVRTTKGLVSDIALEGSEEVGYHRVPLHAAHSLRNFFRLVDAELPQVTQPLLLLRSPRDHVVPPADSARVLGRVSSRDVTEILLQNSFHVATLDHDAPRVFEESAAFLARTGADGADSRPEGEAVSG
>NZ_CP016824.1|WP_003947619.1|1562819_1563434_+|hypothetical-protein
MAEQGAGREENCEPDEQKPPLDEKAAWEAIVAGYGDEPADPPGARPFKSVEEMADLDRELPSVTPDPAGGTDTLEPERPPLGGSVSFAPGIGPRDYRLAEENTPAGKDGKGARKGGAAEDDDEGHFVPPEPPPLPEADTTTRFAWVAVLGGPLLLLLAVLLDWDMTWWLTTLGVGGFLGGFATLVVRMNDGDEDEDDPGRGAVV
>NZ_CP016824.1|WP_067418003.1|1563464_1564247_-|endonuclease
MVRVGPGELPASGRVGGDVVVRVLSYNVRSLRDDPAAVARVVRACAPDLVLVQEAPRFFRWRKPLGRLAAASGLVVLGGGAPAAGPALLCSLRAGVESVHDELLPLTPGLHRRGFSTAVVRFGTVRLGVLSCHLSLQKDERYAQGGMVLERLAALRVEHAVAGGDINERPKGRTFRRLAAELQDGWAVRPWGGEYTSTPADPHQRIDAVFATPGIEVLGCGVPAPGTAAPGVPPFTEDDLVRATDHLPVLAALRVPGTGR
>NZ_CP016824.1|WP_003947621.1|1564532_1565474_-|ROK-family-glucokinase
MGLTIGVDIGGTKIAAGVVDEEGAILNTFTVPTPATAEAIVDAIASAVEGAREGHEIEAVGIGAAGYVDDKRATVLFAPNIDWRHEPLKDKVEQRVGLPVVVENDANAAAWGEYRFGAGKGHDDVICITLGTGLGGGIIIGNKLRRGRFGVAAEFGHIRVVPDGLLCGCGSQGCWEQYASGRALVRYARQRAAATPENAVLLLSLGDGTTEGIQGKHVSEAARQGDPVAVDSFRELARWAGAGLADLASLFDPSAFIVGGGVSDEGELVLDPIRKSFRRWLIGGAWRPHAQVLAAQLGGKAGLVGAADLARQG

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Crispr_ID: NZ_CP016824_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_4

1604516-1604665

Orphan

Consensus_repeat	Method
CAGCCCGGCCGGCGCTTGAGGCCA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP016824_4

>merge|NZ_CP016824|4|1604516-1604665|CRISPRCasFinder
AAGCCCGGCCGGCGATTGAGGCCATCTGTGACCGCACAGGCCGACGGCCCGCGCCCCGAACACGACCCCCATCAGCCCGGCCGGCGCTTGAGGCCAAACCAGCCCGGCCGGCGCTTGAGGCCAAACCAGCCCGGCCGGCGCTTGAGGCCA

>NZ_CP016824|4|4|1604516-1604665|CRISPRCasFinder
AAGCCCGGCCGGCGATTGAGGCCA	TCTGTGACCGCACAGGCCGACGGCCCGCGCCCCGAACACGACCCCCAT
CAGCCCGGCCGGCGCTTGAGGCCA	AACCAGCCCGGCCGGCGCTTGAGGCCAAAC
CAGCCCGGCCGGCGCTTGAGGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_003947655.1\|1600000_1600975_-\|carbohydrate-kinase-family-protein	unknown	unknown	gnl\|CDD\|238917
NZ_CP016824.1\|WP_003947652.1\|1595418_1597155_-\|cytochrome-c-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|238832
NZ_CP016824.1\|WP_079165303.1\|1613732_1614353_+\|DUF3043-domain-containing-protein	unknown	unknown	gnl\|CDD\|378611
NZ_CP016824.1\|WP_015508013.1\|1598574_1599951_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|224029
NZ_CP016824.1\|WP_030306784.1\|1614547_1615249_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NZ_CP016824.1\|WP_008406954.1\|1605419_1606622_+\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|236489
NZ_CP016824.1\|WP_003947667.1\|1615327_1615543_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003947664.1\|1612374_1612653_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067411432.1\|1597151_1598117_-\|cytochrome-c-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|224537
NZ_CP016824.1\|WP_003947656.1\|1601150_1601360_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_094030682.1\|1610883_1612302_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP016824.1\|WP_003947665.1\|1612670_1613447_-\|PspA/IM30-family-protein	unknown	unknown	gnl\|CDD\|224755
NZ_CP016824.1\|WP_008406956.1\|1603081_1604110_+\|cation-transporter	unknown	unknown	gnl\|CDD\|223604
NZ_CP016824.1\|WP_003947662.1\|1610203_1610887_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP016824.1\|WP_079165302.1\|1593620_1594841_-\|L,D-transpeptidase	unknown	unknown	gnl\|CDD\|380079
NZ_CP016824.1\|WP_003947649.1\|1593097_1593499_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225971
NZ_CP016824.1\|WP_067411435.1\|1601513_1602959_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067411438.1\|1606741_1609939_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP016824.1\|WP_003947651.1\|1595023_1595422_-\|cytochrome-c-oxidase-subunit-4	unknown	unknown	gnl\|CDD\|378833
NZ_CP016824.1\|WP_003947659.1\|1604748_1605105_-\|iron-sulfur-cluster-assembly-accessory-protein	unknown	unknown	gnl\|CDD\|272875

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_003947655.1\|1600000_1600975_-\|carbohydrate-kinase-family-protein	gnl\|CDD\|238917	cd01942, ribokinase_group_A, Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.	2.50135e-62
NZ_CP016824.1\|WP_003947652.1\|1595418_1597155_-\|cytochrome-c-oxidase-subunit-I	gnl\|CDD\|238832	cd01662, Ubiquinol_Oxidase_I, Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits in ubiquinol oxidase varies from two to five. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme and a copper ion. It also contains a low-spin heme, believed to participate in the transfer of electrons from ubiquinol to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from ubiquinol on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. It is generally believed that the channels contain water molecules that act as 'proton wires' to transfer the protons. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are believed to be transferred directly from ubiquinol (the electron donor) to the low-spin heme, and directly from the low-spin heme to the binuclear center.	0
NZ_CP016824.1\|WP_079165303.1\|1613732_1614353_+\|DUF3043-domain-containing-protein	gnl\|CDD\|378611	pfam11241, DUF3043, Protein of unknown function (DUF3043). Some members in this family of proteins with unknown function are annotated as membrane proteins. This cannot be confirmed.	2.32472e-66
NZ_CP016824.1\|WP_015508013.1\|1598574_1599951_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	1.11664e-110
NZ_CP016824.1\|WP_030306784.1\|1614547_1615249_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	9.13881e-17
NZ_CP016824.1\|WP_008406954.1\|1605419_1606622_+\|quinolinate-synthase-NadA	gnl\|CDD\|236489	PRK09375, PRK09375, quinolinate synthase NadA.	3.83702e-156
NZ_CP016824.1\|WP_067411432.1\|1597151_1598117_-\|cytochrome-c-oxidase-subunit-II	gnl\|CDD\|224537	COG1622, CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion].	1.92893e-52
NZ_CP016824.1\|WP_094030682.1\|1610883_1612302_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.13525e-43
NZ_CP016824.1\|WP_003947665.1\|1612670_1613447_-\|PspA/IM30-family-protein	gnl\|CDD\|224755	COG1842, PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].	7.40444e-28
NZ_CP016824.1\|WP_008406956.1\|1603081_1604110_+\|cation-transporter	gnl\|CDD\|223604	COG0530, ECM27, Ca2+/Na+ antiporter [Inorganic ion transport and metabolism].	7.52271e-15
NZ_CP016824.1\|WP_003947662.1\|1610203_1610887_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.12618e-65
NZ_CP016824.1\|WP_079165302.1\|1593620_1594841_-\|L,D-transpeptidase	gnl\|CDD\|380079	pfam17964, Big_10, Bacterial Ig domain. This entry represents a bacterial Ig-like domain found associated with transpeptidase domains.	2.15039e-46
NZ_CP016824.1\|WP_067411438.1\|1606741_1609939_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP016824.1\|WP_003947659.1\|1604748_1605105_-\|iron-sulfur-cluster-assembly-accessory-protein	gnl\|CDD\|272875	TIGR00049, Uncharacterized_protein_in_nifU_5'region, Iron-sulfur cluster assembly accessory protein. Proteins in this subfamily appear to be associated with the process of FeS-cluster assembly. The HesB proteins are associated with the nif gene cluster and the Rhizobium gene IscN has been shown to be required for nitrogen fixation. Nitrogenase includes multiple FeS clusters and many genes for their assembly. The E. coli SufA protein is associated with SufS, a NifS homolog and SufD which are involved in the FeS cluster assembly of the FhnF protein. The Azotobacter protein IscA (homologs of which are also found in E.coli) is associated which IscS, another NifS homolog and IscU, a nifU homolog as well as other factors consistent with a role in FeS cluster chemistry. A homolog from Geobacter contains a selenocysteine in place of an otherwise invariant cysteine, further suggesting a role in redox chemistry. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	6.53498e-51
NZ_CP016824.1\|WP_003947651.1\|1595023_1595422_-\|cytochrome-c-oxidase-subunit-4	gnl\|CDD\|378833	pfam12270, Cyt_c_ox_IV, Cytochrome c oxidase subunit IV. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length. This family is the fourth subunit of the cytochrome c oxidase complex. This subunit does not have a catalytic capacity but instead, is required for assembly and/or stability of the complex.	1.88669e-62
NZ_CP016824.1\|WP_003947649.1\|1593097_1593499_+\|hypothetical-protein	gnl\|CDD\|225971	COG3437, COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms].	0.00482668

>NZ_CP016824.1|WP_008406956.1|1603081_1604110_+|cation-transporter
MLAGQWPLGWSVAVVCLAGALTVACSVRLAGLGDVLADRTGWGEALFGAVLFGLVTSLSGIVMTAVSAADDQPELAYSNAVGGIAAQTLAVVAADAFYRRVNLEHAAASLQNLLFGCLLTGLLGLALMASFSPDVTVAGVHPASFVLILFYLGGLHLIHKNTEPMWRAVRTRETVWDVPQSDGAFAQRSTPRLWTEFVVIAGIVVVAGWAVTQAAEGILSATTLRAGFVGAVILGVINGLPEAVTSIAAVRRGAITLAFAAIIGGNSLDVLNLAVGDFAYRGGSLYHAAGNDELFLTSAALVMTTVVLGGLLIRQERGWFRLGFDGALLVVIYAATVTILAF
>NZ_CP016824.1|WP_067411435.1|1601513_1602959_+|hypothetical-protein
MSTERSDQEQERPRRRSPMAVASVAAAVLIVGGGGAYLVTAAASGDAKDGGQPAGADAGDAPPPLELDGHTRGVAPGEPDPGGGVYQAKGKLPEGPGEAAVQRFEAPRETDVAKLAKALGVSGEPRTEGGSWLVGTAKDGQGPLLRVNKQAPGTWSYQGHTVPHGDDCPKGKMCANSSDGAQEDDPVGEKAAKSAAAPVLKALGQDDAKLDAGQVSGGVRVVNAQPVVDGLPTYGWSTGVRVAPDGSLAGGSGQLSEPVKGDTYPVLTAKQALAQLNGASKGDGKVGIGGCASAAPLDGAESADGSAPPKDPCTPGGDAPEREPVAVRGAVFGLSAQFVSGRQALVPSWLFEVRPEGHDRSHTVTRPAVDPEYLAPPATPEKPGTDPGASPGQDRKLSEAESYRADGKELTVRFGGGVCEKYTAEAEEKSASVTVRITSEPQEPGKVCVKMAKQLTAKVTLDKPLGDREVVDEDGSAVPRD
>NZ_CP016824.1|WP_003947656.1|1601150_1601360_+|hypothetical-protein
MSNQSVKDAGPLELDHGFEVLRGDCARMSKDWPAPHGAPRTAVPLSAIHGVRVTPASVRLIDGMSEYGD
>NZ_CP016824.1|WP_003947655.1|1600000_1600975_-|carbohydrate-kinase-family-protein
MRIAVTGSIATDHLMTFPGRFADQLVADQLHTVSLSFLVDQLDVRRGGVAANICFGMGQLGTAPVLVGAAGADFDEYRAWLDRHGVDTGSVRISEVLHTARFVCTTDADHNQIGSFYTGAMSEARLIELQAVAERVGGLDLVLIGADDPEAMLRHTEECRSRNIPFAADFSQQIARMDGAEIRTLLDGATYLFSNEYEKGLIESKTGWSDEEILGRVGHRVTTLGSRGVRIERAGEDPVEVGVPEEETKADPTGVGDAFRAGFLSGLSWGVSLERAAQVGCMLATLVIETVGTQEYTLGRVPFMDRFTKAYGHDAAAEVQAHLV
>NZ_CP016824.1|WP_015508013.1|1598574_1599951_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MPYFDAASAAPLHPTARQALLASLDEGWADPARLYREGRRARLLLDAARESAAESVGCRPDELVFTPSGTQAVHWGMAGALAGRRRTGRHLVVSEVEHSSVLHTAESFEAEGGEVDRVGVESTGRVPAQAFAAALRADTALACLQSANHEVGTAQPVEEVAEACRAATVPLLVDAAQSLPWGPVPGPWSLLTGSAHKWGGPPGVGLLAVRKGTRFAPRGPADERESGRAPGFGNLPAVVAAAASLRAVRAEAEAEGVRLRELVDRIRLRLPELVDDMEVVGDPVHRLPHLVTFSCLYVDGEALLHELDRAGFAVSSGSSCTSSTLTPSHVLRAMGVLSEGNVRVSLPHGTPATDVDHFLTVLPEAVRAVRARLGAPGAEPPAVQEALVVDALGRRCPVPVIELAKVIDRVPVGGTVTVLSDDEAARLDIPAWCRMREQEYVGEEPAVRGTAYQVRRLV
>NZ_CP016824.1|WP_067411432.1|1597151_1598117_-|cytochrome-c-oxidase-subunit-II
MSPNGSDRSSRRPMRRKLPQVLTAGLILATATGCTYEDSPRLGMPTPVTEEAPIILSLWQGSWAAALVTGVLVWALILWACFAYRRTRTKIEVPPQTRYNMPLEALYTVVPVLIVSVFFFFTARDESKLLELSDEPAHTINVVGFQWSWAFNYVEDVDGDTATGDAKKDKDLKAIPDRFKDAFPEGAEGVHAVGTPGERNPQNGNPGPTLWLPKGEKVRFVLTSRDVIHSFWVVPFLMKQDVIPGHTNSFEVTPNKEGTFMGKCAELCGVDHSRMLFNVKVVSPERYQQHLEELREKGQTGYVPAGIEQTDPARNSEKNQL
>NZ_CP016824.1|WP_003947652.1|1595418_1597155_-|cytochrome-c-oxidase-subunit-I
MSILNEPQGDAAADDSYENELPVRRKQPGNVVVKWLTTTDHKTIGTLYLVTSFIFFCIGGLMALVMRAELARPGTQIISNEQFNQAFTMHGTIMLLMFATPLFNGFANWIMPLQIGAPDVAFPRLNMFAYWLYLFGSLIAVAGFLTPQGAADFGWFAYSPLSDAVRSPGVGADMWIMGLALSGFGTILGSVNFITTIICMRAPGMTMFRMPIFTWNVLLTGVLVLLAFPVLAAALFALEADRKFGAQVFSPENGGALLWQHLFWFFGHPEVYIIALPFFGIVSEIIPVFSRKPIFGYMGLVGATIAIAGLSVTVWAHHMYVTGGVLLPFFSFMTFLIAVPTGVKFFNWIGTMWKGSLSFENPMLWSVGFLVTFLFGGLTGVILASPPLDFHVSDSYFVVAHFHYVVFGTVVFAMFAGFHFWWPKFTGKMLDERLGKITFWTLFIGFHGTFLVQHWLGAEGMPRRYPDYLAADGFTALNTVSTISSFLLGLSLLPFFYNVWKTAKYGKKIEVDDPWGYGRSLEWATSCPPPRHNFLTLPRIRSESPAFDLHHPEIAAMDHLEDHDPQPKAVAGTKEAGK
>NZ_CP016824.1|WP_003947651.1|1595023_1595422_-|cytochrome-c-oxidase-subunit-4
MKIQGKMFIWLSAFILLVAVVYGLWSREPAGTTALFLAFGLSIMVGFYLAFTARRVDAMAQDDKEAEVADEAGEVGFFSPHSWQPLSLGIGGALAFLGVVFDWWLMYFSAPMLLIGLWGWIYEYYRGENQNQ
>NZ_CP016824.1|WP_079165302.1|1593620_1594841_-|L,D-transpeptidase
MLVVALGAGATACGSSETHPLAAAPYDAAQDVAISAGGRTKADPDKPLEVTATGKGRLTDVVAVDASGRRVAGELSADGTRWRTTGPLAAAARYTVTASTENGDGGPGRRTMTFDTAAQGKGKDKRLKVTFGPEKGTYGVGQPIVAELNAPVEDRKARAVVENSLKVTSKPAVETGGWYWVDSKTLHYRPKEYWPANATVTARSELGGVRVTDKVRGGAGKPLTIRTGSKIEAVVDASRHAMTVFKDGEELTTLPVTTGKPGFATRNGVKVVLGKEYFVRMRGTSVGIAAGSSESYDLPVYYATRVTWSGEYVHAAPWSVGSHGSANVSHGCVGMSTKNAAWFFETVREGDLVHVVNSIGEDMDPFGNGFGDWNVDWADWKAGSANAPEAPPGKAPGPADRLSPRI
>NZ_CP016824.1|WP_003947649.1|1593097_1593499_+|hypothetical-protein
MQATATVLVYSDNSATREQVRLAAGRRPAADVPPVRFVECATLPAVLKELEHGGIDACVLDGETAPIGGMGVCRQLKDEIFQCPPVLLLMGRPQDAWLATWSRADAAVTLPVEPVEFAGALAALLRPRKPVTA
>NZ_CP016824.1|WP_003947659.1|1604748_1605105_-|iron-sulfur-cluster-assembly-accessory-protein
MSVQDEKTTVSDGILLSDAAAAKVKALLDQEGREDLALRVAVQPGGCSGLRYQLFFDERSLDGDVVKDFGGVKVVTDRMSAPYLGGASIDFVDTIEKQGFTIDNPNATGSCACGDSFS
>NZ_CP016824.1|WP_008406954.1|1605419_1606622_+|quinolinate-synthase-NadA
MTTAQPRTDLDVQPTPLALLLLGREADPASERGVDCPGDLPSPSDPDLVARARAAKEKLGDKVFVLGHHYQRDEVIQFADVTGDSFKLARDAAARPEAEYIVFCGVHFMAESADILTSDEQKVVLPDLAAGCSMADMATAEQVAECWDVLSEAGVADQVVPVAYMNSSADIKAFTGKHGGTICTSSNAKRALEWAFEQGQDPATTKILFLPDQHLGRNTAVRDLGMSLEDCVVYNPHKPNGGLTAEQLRDARMILWRGHCSVHGRFSLESVEDVRARVPGVNVLVHPECKHEVVAAADLVGSTEYIIKTLEAAPRGSKWAIGTELNLVRRLANRFAEEDKEIVFLDRTVCFCSTMNRIDLPHLVWTLESLAEGTLVNRIEVDKETEDFAKLALERMLALP
>NZ_CP016824.1|WP_067411438.1|1606741_1609939_-|efflux-RND-transporter-permease-subunit
MSWLSRFSLAQRALIGLMSIIALLFGAIAIPQLKQQLLPSIELPMVSVLAPYPGASPDVVEKQVVEPLEKSIDAVEGITGITATASEGNAVLMAQFDFGSADTQQLVADIQQAVNRSRAMLPDDVDPQVVAGSTDDIPTVVLAVTSDKDQQALAGQLERTVVPSLESIDGVGQVSVDGVRELQIAVTPDDADLAKAGLSSADLVQALQAAGATVPAGSFDEKGENRTVQVGGGFTSVKQIEDLRIARAAGGQGGQGGPGAQAGPGDAGKAPAPVRLGSVAKVEQQQATATSLTRTNGEPSLAVVVTMDRDGSAVAISDAVAEKLPELRADLGDSSELTVVSDQGPAVAKSIEGLTTEGALGLVFAVVIILVFLASIRSTLVTAVSIPLSVVLALIVLWTRDLSLNMLTLGALTIAIGRVVDDSIVVLENIKRHLGYGEERKEAILTAVKEVAGAVTSATLTTVAVFLPIGLVGGMVGELFGSFSLTVTAALLASLLVSLTVVPVLSFWFLRAPKGTPEDAEAARAAAEEKEARSRLQRLYVPILKFATRRRLTSLAIAVAVLLGTFGMAPLLKTNFFDQGEQDVLSVKQELAPGTSLAATDEAAEKVEALLKETEGVEDYQVTIGSSGFMAAFGGGTDTNQASYQVKLADSASSETVQKALDKGLAGLEGIGDTRVAAGDGFASQDLSVVVKASEADVLAKASEQVREEVAKLDDVTDVQSDLSQSVPRISVSANEKAAAAGFTDASLGQVVAQSVRGTTAGQVVLDDAERDIVVKSAKPAETLAELRALPLGPVKLGQIADVELVDGPVSMTRIDGSRAATVTARPTADNTGAVTAELQTKINALELPEGATATIGGVSADQDEAFGQLGLAMLAAIAIVFMLLVATFRSLVQPLILLVSIPFAATGAVGLLIATGTPMGVPAMIGMLMLIGIVVTNAIVLIDLINQYRDKGYGIIEAVIEGGRHRFRPILMTALATIFALIPMALGVTGEGGFIAQPLAVVVIGGLITSTVLTLVLVPTLYAMVELRKERRAAKKAAKREGKADVPGQGGTPAEEQTPEPARS
>NZ_CP016824.1|WP_003947662.1|1610203_1610887_-|response-regulator-transcription-factor
MTIRVLLADDQALLRSAFRVLVDSEPDMEVVGEAADGDQALALARAARPDVVLMDIRMPGTDGLAATRLISADPALDTVRVVMLTTFEVDEYVVRALRAGASGFLGKGSEPAELLGAIRVAHAGEALLSPAATKGLIASFLAQSGHGADERPGAREERLAALTGREREVLVHVAGGLSNDEIAGRLQVSPLTVKTHVNRAMAKLGARDRAQLVVTAYETGLVRPRTA
>NZ_CP016824.1|WP_094030682.1|1610883_1612302_-|two-component-sensor-histidine-kinase
MRPPRNGVRTPPDGAVRRPGRAERYRQRTPEGPVSPTPTTPAAPPRRAYARLRRKARAHPRLLDAVLAVGVLLCMLASSLTDPHHPDGPTWQAAPPDATGFTLMALGAAALVLRRRAPRTVLAATSAASLAVLVSSDPRTPVVMSAAVALYTVAARTDRPTTWRIGLLTSAGLTAGAMLCGNLPWYAQENFGIFAWLGLAAAAGDAVRSRRAYITAIHERADRAERTREEEARRRVAEERLRIARDLHDVVAHHIALVNVQAGVAAHVMDRRPDQAKEALAHVREASRSALDELRATVGLLRQSGDPEAPTEPAPGLARLDDLAERFRNAGLPVEIACPDRGDPLPAAVDLAAYRVVQEALTNVHKHAGPGARAEVSIVPVDGQVEITVLDGGPAATPAPGAAPAEPPPGGGHGLLGMRERVTALGGTCTAGPRFGGGFRVHAILPAQGAAPANRPPAPVPPARTDAPKDGR
>NZ_CP016824.1|WP_003947664.1|1612374_1612653_-|hypothetical-protein
MIVRIMGEGQVKLADSHFAELNALDDELLTEMENGDGPGFRATLTALLDKVRELGTPLPDDSLEPSELILPAPEASLEEVRELLSDDGLIPG
>NZ_CP016824.1|WP_003947665.1|1612670_1613447_-|PspA/IM30-family-protein
MGMIFRAKANKALDRAEDPRETLDYSYQKQLELLQKVRRGVADVATSRKRLELQLNQLQKKSSDLEGQGRKALALGREDLAREALSRRAALQGQITDLETQHQTLQGEEEKLTLAAQRLQAKVDAFRTKKETIKATYTAAQAQTRIAESFSGISEEMSDVGVAIQRAEDKTAQLQARSGAIDELLASGALDDQSGLQKDDIQLELDRLSGGSDVELELQRMKAELAGGPSGGQQAIEGGAEGEKDRQQPEDTPRFEKN
>NZ_CP016824.1|WP_079165303.1|1613732_1614353_+|DUF3043-domain-containing-protein
MRPHTVRLGFVFRSRANSEKAPAAQAAPSTEPRDPQPPKGRPTPKRAQAQSQRRSVTNTQMSRKEASRKQRDARRAEMARQREALNNGDERYLPARDKGPVRKFARNYVDSRFAVAEFFLPFAVVILILSMIRVPQLQNIALLLWMALIVLIVIDSVVTSMKLKRALRERFEGQPMKGAVMYALMRTLQMRRLRLPKPMVKRGEQP
>NZ_CP016824.1|WP_030306784.1|1614547_1615249_+|methyltransferase-domain-containing-protein
MVARQLDEQLAARFAVGRRLRVLDVGMGEGRQALRLARLGHQVTGVESDPALVAAAEEALAKEPEGIRERFRPVVGDGHDTGVHFLPGSFDVVLCHGVLMRVESPDALLAGLGRMLAPGGLLSLLVRNADALALCAGLAGDWRGALDAFGAESAAEGPVRADRLAPLTAALAGIGAPLERWYGVRVLAGRASDGPVPVDEAEFQALLAAEERAGRTDPYRSVAALLHLCGVRG
>NZ_CP016824.1|WP_003947667.1|1615327_1615543_-|hypothetical-protein
MVPWTWRFEKADGTEVSPSVEPDEFSTQGDAESWLGEYWKELLEGGVEQVRLFEDTTEIYGPMSLSEAQTA

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Crispr_ID: NZ_CP016824_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_5

2075937-2076024

Orphan

Consensus_repeat	Method
GGCCTCAAACGCCGGCCGGGCTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_5

>merge|NZ_CP016824|5|2075937-2076024|CRISPRCasFinder
GGCCTCAAACGCCGGCCGGGCTGTTGGTAGCTGGGGTCCGCCTCAACCGTGCCGGTCAATGATTGGCCTCAAACGCCGGCCGGGCTAT

>NZ_CP016824|5|5|2075937-2076024|CRISPRCasFinder
GGCCTCAAACGCCGGCCGGGCTGT	TGGTAGCTGGGGTCCGCCTCAACCGTGCCGGTCAATGATT
GGCCTCAAACGCCGGCCGGGCTAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067418042.1\|2088804_2092125_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173796
NZ_CP016824.1\|WP_008411884.1\|2062574_2063246_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|237133
NZ_CP016824.1\|WP_003948048.1\|2063313_2063973_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
NZ_CP016824.1\|WP_067412015.1\|2068777_2069980_+\|transporter	unknown	unknown	gnl\|CDD\|223551
NZ_CP016824.1\|WP_067412019.1\|2081580_2083035_-\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223154
NZ_CP016824.1\|WP_003948050.1\|2066273_2066468_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412016.1\|2077544_2078990_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP016824.1\|WP_067412021.1\|2083930_2086516_+\|aminopeptidase-N	unknown	unknown	gnl\|CDD\|274121
NZ_CP016824.1\|WP_079165318.1\|2087166_2088363_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP016824.1\|WP_008411876.1\|2073546_2074038_-\|ribose-5-phosphate-isomerase	unknown	unknown	gnl\|CDD\|235509
NZ_CP016824.1\|WP_003948061.1\|2080782_2081421_+\|superoxide-dismutase	unknown	unknown	gnl\|CDD\|223678
NZ_CP016824.1\|WP_003948049.1\|2064229_2065627_-\|trigger-factor	unknown	unknown	gnl\|CDD\|234956
NZ_CP016824.1\|WP_003948057.1\|2074410_2075847_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|273797
NZ_CP016824.1\|WP_008411881.1\|2067241_2068444_+\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|226122
NZ_CP016824.1\|WP_018468128.1\|2076624_2077218_-\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|376871
NZ_CP016824.1\|WP_067412023.1\|2086601_2087021_-\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP016824.1\|WP_003948063.1\|2083121_2083766_-\|DSBA-oxidoreductase	unknown	unknown	gnl\|CDD\|376526
NZ_CP016824.1\|WP_015507892.1\|2070215_2071334_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP016824.1\|WP_079165317.1\|2071493_2072723_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|234945
NZ_CP016824.1\|WP_008411871.1\|2079175_2080624_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067418042.1\|2088804_2092125_+\|S8-family-serine-peptidase	gnl\|CDD\|173796	cd04857, Peptidases_S8_Tripeptidyl_Aminopeptidase_II, Peptidase S8 family domain in Tripeptidyl aminopeptidases_II. Tripeptidyl aminopeptidases II are member of the peptidase S8 or Subtilase family. Subtilases, or subtilisin-like serine proteases, have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure (an example of convergent evolution). Tripeptidyl aminopeptidase II removes tripeptides from the free N terminus of oligopeptides as well as having endoproteolytic activity. Some tripeptidyl aminopeptidases have been shown to cleave tripeptides and small peptides, e.g. angiotensin II and glucagon, while others are believed to be involved in MHC I processing.	1.15162e-63
NZ_CP016824.1\|WP_008411884.1\|2062574_2063246_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|237133	PRK12553, PRK12553, ATP-dependent Clp protease proteolytic subunit; Reviewed.	2.22318e-122
NZ_CP016824.1\|WP_003948048.1\|2063313_2063973_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.62266e-120
NZ_CP016824.1\|WP_067412015.1\|2068777_2069980_+\|transporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	1.67867e-40
NZ_CP016824.1\|WP_067412019.1\|2081580_2083035_-\|aspartate-aminotransferase-family-protein	gnl\|CDD\|223154	COG0076, GadB, Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism].	1.59022e-79
NZ_CP016824.1\|WP_003948063.1\|2083121_2083766_-\|DSBA-oxidoreductase	gnl\|CDD\|376526	pfam01323, DSBA, DSBA-like thioredoxin domain. This family contains a diverse set of proteins with a thioredoxin-like structure pfam00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyze one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways. This family also contains members with functions other than HCCA isomerisation, such as Kappa family GSTs, whose similarity to HCCA isomerases was not previously recognized. Some members have been annotated as dioxygenases, dehydrogenases, or putative glycerol-3-phosphate transfer proteins, but are most likely HCCA isomerase enzymes.	2.6397e-08
NZ_CP016824.1\|WP_067412016.1\|2077544_2078990_+\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	3.30807e-161
NZ_CP016824.1\|WP_067412021.1\|2083930_2086516_+\|aminopeptidase-N	gnl\|CDD\|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0
NZ_CP016824.1\|WP_079165318.1\|2087166_2088363_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	6.35755e-57
NZ_CP016824.1\|WP_008411876.1\|2073546_2074038_-\|ribose-5-phosphate-isomerase	gnl\|CDD\|235509	PRK05571, PRK05571, ribose-5-phosphate isomerase B; Provisional.	1.47647e-84
NZ_CP016824.1\|WP_003948061.1\|2080782_2081421_+\|superoxide-dismutase	gnl\|CDD\|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	5.17808e-80
NZ_CP016824.1\|WP_003948049.1\|2064229_2065627_-\|trigger-factor	gnl\|CDD\|234956	PRK01490, tig, trigger factor; Provisional.	7.22577e-154
NZ_CP016824.1\|WP_003948057.1\|2074410_2075847_+\|amino-acid-permease	gnl\|CDD\|273797	TIGR01773, GABA_permease, gamma-aminobutyrate permease. GABA permease (gabP) catalyzes the translocation of 4-aminobutyrate (GABA) across the plasma membrane, with homologues expressed in Gram-negative and Gram-positive organisms. This permease is a highly hydrophobic transmembrane protein consisting of 12 transmembrane domains with hydrophilic N- and C-terminal ends. Induced by nitrogen-limited culture conditions in both Escherichia coli and Bacillus subtilis, gabP is an energy dependent transport system stimulated by membrane potential and has been observed adjacent and distant from other GABA degradation proteins. GabP is highly homologous to amino acid permeases from B. subtilis, E. coli, as well as to other members of the amino acid permease family (pfam00324). A member of the APC (amine-polyamine-choline) transporter superfamily, GABA permease possesses a "consensus amphiphatic region" (CAR) found to be evolutionarily conserved within this transport family. This amphiphatic region is located between helix 8 and cytoplasmic loop 8-9, forming a potential channel domain and suggested to play a significant role in ligand recognition and translocation. Unique to GABA permeases, a conserved cysteine residue (CYS-300, E.coli) located at the beginning of the amphiphatic domain, has been determined to be critical for catalytic specificity. [Transport and binding proteins, Amino acids, peptides and amines].	0
NZ_CP016824.1\|WP_008411881.1\|2067241_2068444_+\|acyltransferase-family-protein	gnl\|CDD\|226122	COG3594, NolL, Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism].	3.19877e-32
NZ_CP016824.1\|WP_018468128.1\|2076624_2077218_-\|biotin-transporter-BioY	gnl\|CDD\|376871	pfam02632, BioY, BioY family. A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin. BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes.	3.42809e-30
NZ_CP016824.1\|WP_067412023.1\|2086601_2087021_-\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	6.19108e-10
NZ_CP016824.1\|WP_015507892.1\|2070215_2071334_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	4.6734e-35
NZ_CP016824.1\|WP_079165317.1\|2071493_2072723_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|234945	PRK01346, PRK01346, enhanced intracellular survival protein Eis.	5.2022e-161
NZ_CP016824.1\|WP_008411871.1\|2079175_2080624_+\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	6.25042e-155

>NZ_CP016824.1|WP_003948057.1|2074410_2075847_+|amino-acid-permease
MTSQPPLAKVEQAPDGPAGPTPAEGQGSDGLQAGLKNRHLSMIAIGGVIGAGLFVGSSAGIAAAGPAILVSYAIVGLMVVLVMRMLGEMAAARPSSGSFSAYADMALGRWAGFSIGWLYWFFWVVVLAVEATAGAVILNGWIPAVPQWGWALIVMVVLTGTNLASVASYGEFEFWFAGIKVVAIAAFVLIGVLAVFGVLPGSDNPGAGFANLTAHGGFLPNGAGSILTGVLMVVFSFMGSEIVTLAAGESANPQRAVRKATNSVIWRIAVFYLGSIFVVVALLPWDSKSIVEDGSYVAALNSIGIPHAGQIMNVIVLTAVLSCLNSGLYTASRMAFSLGKRGDAPAAFARVNARGVPQAAILGSVVFGFAAVWFNYQWPETVFQFLLNSSGAVALFVWLVICFSQLRLRGVIARETPEKLVVRMWLFPYLTWVTIAGIVFVIGYMLFDEAGRTQMALSLLVAVLVVAVSLVKHRGARV
>NZ_CP016824.1|WP_008411876.1|2073546_2074038_-|ribose-5-phosphate-isomerase
MRVYLGSDHAGYELKNHLVDWLKANGHDPVDCGPHLYDAADDYPPFCLRAAERTAADPDSLGIVIGGSGNGEQIAANKVKGVRCALAWSKETAALGREHNNANVVSVGARMHTEEEATDFVATFLATPYSDEARHTRRIDMLSAYETTGELPPIPAHHPQHDA
>NZ_CP016824.1|WP_079165317.1|2071493_2072723_+|GNAT-family-N-acetyltransferase
MTSGAEVLRAEDWDQWYSTLELAFGGVPEAPEERELYQRLTEPERSLVVWDGSEVVGTAGGFTFRVTVPGGRPVAAAGVTMVGVAPTHRRRGILTAMMRRQLDDVRARGEALAMLTASEPGIYGRFGYGIATLKLSAEIDTAQVRLTVPEGTDEVVLRRADPREALKVCEEVYARQVAGRPGMLVRAPGWEEQGLLDPPGNRAGGSPLQCVLAERDGEVVGYTRYRTHPSWGLGGPDGAVTVQDLEASGPAAHAALLRYLCGIDLMRTVKLPSRPVDDAWQYLVSDARRCVPRLGDVLQVRLVEVGAALQQRSYQAPLDVVLEVTDAFCPWNEGRWRLSADAEGAACERTEAEPDLALSVRELGAAYLGGVPLSGLAAAGRVRELRPGALARTSTAFGSDVAPWLPHGF
>NZ_CP016824.1|WP_015507892.1|2070215_2071334_-|serine/threonine-protein-phosphatase
MRKRWHRARTGLRKSAVDYFRGDGSDWVAFAGLFLTVPAIAVGTIVGPEWCDPAALVLPVIAGGLVLRPATLLLLYASATAALVVESLVLGSGPTSQVPVGVTPGTVLTVAAAGLFGLVIAQFRSRVGVPWRRGGTMLFDLRERIRVQSRLPHLPSGWHHEMALRPAGGQSFSGDFVVAARTHGGRTLEVVLTDVSGKGMDAGSRALLLSGAFGGLLGSLPPHAFLPAANGYLLRQDWDEGFATSIHLVLDLDSGDYELFSAGHLPAVQLHSGTGQWEEKAAEGPLLGVYDGCQFDPVKGSLAPGDVLMLYTDGLVEAAGRDLSEGIDRLTGEADRYVPGGFEGAAWHLIEAVAKDVNDDRALLLLSRKPTT
>NZ_CP016824.1|WP_067412015.1|2068777_2069980_+|transporter
MGGAFVAAAVLARLGGRIGLPTIPLFILAGILLGPHTPGVVLVSDPHDLEMLSALGLVLLLFYLGLEFHIDDLKAGGRNMALAGGIYLALNVGAGLGFGFALGWGVSEALVLAGVLGFSSSAIVTKILVDTRRLGNPETKPILGIIVVEDVFIALYLAALQPILSGADSLSTALVDGGKAFGFLIALALVARYGTRVVGRLINTPDDEILTISFLGAAVLMAGVSEWFGVADAIGAFMVGLMLGSTTSGKRILKLVHPLRDAFGAIFFFVFGLSINPGDLPGVVWPVLIAVALTLSMNVISGITAARIYRFGAQPAANIATTLLARGEFALILATMAAAAGLDARLSPFIAGYVLLLAIMAPLAAKQSDWLARILPGGKSGGAGGDAGASGASVPERVSV
>NZ_CP016824.1|WP_008411881.1|2067241_2068444_+|acyltransferase-family-protein
MTNSLRPHGHHSQPLPPVQEPADGMTAPRPSPTSQERPPGPERPPAAAAKPAKSRDPFFDNAKYLAIVLVAMGHAWQPLTSDSRAAEALYMVVYAFHMPAFIVISGYFSRSFDMRKDRLQRLVTGVAVPYILFETAYSLFKRWADDDPTHPISLLDPWYLTWFLIALFIWRLTTPLWKIVRWPVPLALALALLASVSPDIGDDLDLQRVLQFLPFFVVGLVLKPEHFQMVRRREVRLLALPVFAAALLVGYWAAPRMSSAWFYHRDSAQEMGFAWWVGVIMTLALFGCSMVLTACFFAWVPRRHMWFTALGAGTLYGYLLHGFLAKGSRFWGWYETYDWVRTPLGMIGVTLIAGAIVTVLCTPPVQRLFRFAMEPKMNWAFKRDATELARERAKSGAAIR
>NZ_CP016824.1|WP_003948050.1|2066273_2066468_-|hypothetical-protein
MAISLSVVVLLAIVMVVLIRGGSLKAGPAVVAILFGFFLASSGMAPAIQRVLDSIAQTVSGISF
>NZ_CP016824.1|WP_003948049.1|2064229_2065627_-|trigger-factor
MKSAVETLNPTRVRLTVEVPFEELKDSLDAAYKKINQQVTVKGFRKGKIPARVIDQRFGRGAVLEEAVNDALPKFYTEAVNEGELNVLGQPEVDITELKDGELLAFTAEVDIRPEIEIPDYSGIEVEVDPVEVTDEDVDKAVEELRERFASTAPVERPAEDGDVVTLDLEAKVDGEVLEDGLASDVSYTIGSGELLDGIDDAVKGLEAGGEATFTSELKGGSAAGKEAEITVKVSKVAKRELPELDDDFAQLASEFDTLEEVRADSRKRLENMKQYDQATQAQERVLDALLELAEVPIPEKLLEDEVNTRKHNLEHHQLGQMGLDLAKYLEIQGKTAEEFDAETREQAIKGIKTQFILDELVNKEKLNVDQEELTEHLMRRAASSGMSPDQFAQAVVEGGQVPMLVGEVARGKALAVVVEAVTVKDTNGEVVDLSDDEDEAAEATEAAAGQTEGDAAEAKADSDK
>NZ_CP016824.1|WP_003948048.1|2063313_2063973_-|ATP-dependent-Clp-protease-proteolytic-subunit
MRRPGAVVRRAGGYVTNLMPSAAGDPSIGGGLGDQVYNRLLGERIIFLGQPVDDDIANKITAQLLLLASDPDKDINLYINSPGGSISAGMAIYDTMQFIKNDVVTIAMGLAASMGQFLLSAGTPGKRFALPNAEILIHQPSAGLAGSASDIKIHAERLLHTKKRMAELTAFHTGQSVEQITRDSDRDRWFSADEAKEYGLIDEVIASAANVPGGGGTGA
>NZ_CP016824.1|WP_008411884.1|2062574_2063246_-|ATP-dependent-Clp-protease-proteolytic-subunit
MNNFPGSGALGADGEYAGPRAESRYIVPRFVERTSQGVREYDPYAKLFEERVIFLGVQIDDASANDVMAQLLCLESIDPDRDISIYINSPGGSFTALTAIYDTMQFVKPDIQTVCMGQAASAAAVLLAAGSPGKRMALPNARVLIHQPYSETGRGQVSDLEIAANEILRMRAQLEEMLAKHSTTPLDKIRDDIERDKILTAEDALAYGLIDQIVSTRKLNAGV
>NZ_CP016824.1|WP_018468128.1|2076624_2077218_-|biotin-transporter-BioY
MSTAAASTRPGQVLADLLPASTVPRARLRDAALVTGGAALTGLAAQIVLPVPGSPVPVTGQTFAALLVGTALGAGRGFASLALYALVGMAGVPWFAEGTSGASMPSFGYVLGMLLAATVVGALARRGADRSVLRTAGLMVLGSALIYAVGVPYLALSTGMTLTSAVAAGLVPFLIGDALKAALAMGALPLAWRLTRD
>NZ_CP016824.1|WP_067412016.1|2077544_2078990_+|amino-acid-permease
MHDAPAGPGDPGATSATTARDPFDSAEPLGHGLKQRHLTMLGLGGVIGAGLFVGSGAGIAVAGPGIVVSYLIAGTLAMLVMRMLGEMSAAMPSSGSFSVHAERALGRWAGFSVGWLYWFLLVVVLAVEATGAAQIANGWVPSVPQWAWVLVFMLVFTGANLAAVKHFGEFEFWFAALKVGAIVLFLVLGVLAILGLLPETEPVGLAHLSGDGGFLPNGWSGVISGVLAVVFAFGGLEVVTIAAAESDDPARSVARAVRSAVYRILFFYVGSMLVIVTLLPWTAMRPGLSPYVAVLDGIGIPSAGQIMNIVVFVALLSALNANLYGSSRMVFSLAERGEAPRALLKVARGGVPRRAVLASVAFGFVSVLLNLKWPDSVFLYMLNAVGAVLLFVWALIAVSQLRLRRLIEREAPERLVLRMWGYPWLTWAALVAMAAVFTLMLFDSTARPQLLWSSGAAALVLLVAGVREWRLRRGTGAAATG
>NZ_CP016824.1|WP_008411871.1|2079175_2080624_+|amino-acid-permease
MTRTTLTPGDTPGADQRPGGDQASDTGSALSNGLKQRHLSMIALGGVIGAGLFVGSGAGIAAAGPSIVFAYAASGLLVMLVMRMLGEMSAANPASGSFSVHAERAIGPWAGFTSGWAFWFLLCVAVGLEGIGAAEIMSGWLPGTPEWAWVALFMVIFCGTNLAAVKNFGEFEFWFATLKVVAIVVFLVIGVLAILGVLPGSEAPGTSNLTGEGGFLPNGSEGFIIGLLASVFAYGGLETVTIAAAESERPAEGVAKAVRTAMWRIGVFYVGSMAVIVTLVPWDDPAVAEKGPYVATLDHLGIPGSGQIMNVVVLIALLSAMNANIYGASRMACSLVARGQGPRKLGRVFNGVPRIAVLASSFFGFVCVLLSYWRPDDVFAWLLNMIGAVILVVWFFTAASQLLLRRRTEREAPERLVVRMWLFPGLTWVALAAMAGVFVLMAKEPDTRVQLLSTGSLTVALALAGYLLQRKRAAAPAGVGKG
>NZ_CP016824.1|WP_003948061.1|2080782_2081421_+|superoxide-dismutase
MSVYTLPELPYDYAALEPVINPAIIELHHDKHHAAYVKGANDTLEQLAEARDKDQWGAVTGLEKSLAFNLSGHILHSIYWHNMTGDGGGEPLAEDGVGELADAIRESFGSFAGFKAQLTKAAATTQGSGWGVLAYEPLSGRLIVEQIYDHQGNVGQGSTPILVFDAWEHAFYLQYKNQKVDFIEAMWRVVNWQDVARRYASAKARENVLLAP
>NZ_CP016824.1|WP_067412019.1|2081580_2083035_-|aspartate-aminotransferase-family-protein
MPTPEPPARPDVLKELAALREADAPTRGGRTFAYVYDPAVEGLDALAADAYRAFADVNALDMTVFPSVARLENDLVARVAAHLGAPGCQGTFTSGGTESILLAVKTARDHARATRGVRAGELVLPATAHAAFHKAAHYLGLTPVTVPVDPETYRADPAATARALTPDTVLVVASAPSYAHGVLDPVAEIAALAAEAGVLCHVDACVGGWLLPFLRRAGREVPDFGLTVPGVTSLSVDLHKYGYADKGASVVLYRDAALRRHQYFAHADWPGYPVVNPTVQGTKSAGLLAQAWAVLRYFTDEDYTALAARVADAETRLLTGLAALDGLRVLGTPAAGLVAVTATGPDGTPDLSTVLHLADEMRARGWYLQPQLAHGALPPNLHLTLAPATADRVDALLADLTTALATARTLPPATPPPDLAALAATLDPDTLTDEEAAAVLTYAGLGPDTGTPDRMAPVLALLAALPTRLKERLLTEYIGSLFQI
>NZ_CP016824.1|WP_003948063.1|2083121_2083766_-|DSBA-oxidoreductase
MTDPQQNTEVTADFWFDPLCPWAWMTSRWMLEVEKVRPVRVRWNVMSLAVLNEDRLDELPEGYRELLTQAWGPVRVVIAAQQLHGAEVAGPLYTALGTRYHNQQQPKDRATLVAALEEVGLPADLADYADKDTYDAELRASHAAGITKVGQDVGTPVIAVPGADGEEVAFFGPVVTPAPKGDQAAALWDGTLLVASVPGFYELKRTRTAEPSFD
>NZ_CP016824.1|WP_067412021.1|2083930_2086516_+|aminopeptidase-N
MPGENLTRDEARERAALVAVESYDVALDLRSALGEVTGDGPRTFRSVTTIRFAGLRPGAAAFVDLIAPSVSAVTLNGRALDVAEVFDGTRIALEKLEAENTLVVDAQCAYSRTGEGMHRFVDPQDGEVYLYTQYEPADSRRVYANFEQPDLKGRYRFSVTAPEGWGVWSNGAGERDADGVWRFAETEPISTYITCVVAGPYHYVTDDYRRTLPDGSELRIPLGAMCRKGLAPHFDAEDIFLVTKQGLDFFHDHFGYPYPFGKYDQAFVPEYNLGAMENPGMVTFREEYIYRGKVTAASYERRATTILHEMAHMWFGDLVTMKWWDDLWLKESFADFMGSFALVEATRFTNGWTTFANNRKAWAYRADQLPSTHPITADIRDLQDAKLNFDGITYAKGASVLKQLVAYVGRDAFLEGARRYFQRHAFGNTTLADLLAVLEETSGRDLAGWSKAWLQTAGVNALTPELTLDAENRITELAVAQEAAASHPELRPHRVAVGLYRLDGVEGALVRYARAELDVTGPRTVVTELAGAEAPDLVLVNDDDLTYCKVRFDENSLATLRSRLGDIADPLARALCWSALWNMTRDGLMPARNFLSLVLEHAGRESDIGVLQMLHAWARTALVHYVVPARRDEAGRALAQGALAELRAAEPGGPAQLTWARFFASVASDEADLQLLGALLDGPARIDGLDMDQELRWTFLEPLATYGVVDEERIAAELARDDTASGKRHQVRCLAARPSEAVKAQAWAQVVESDALSNALVEATIAGFAQPSQRELTAPYAAKYFEAIGRVWEERSIQIGVLVVRGLFPSLQDGPEPLAAADAWLGEHTDAPPALRRLVLESRDDLARAHRAQVTDAGTGA
>NZ_CP016824.1|WP_067412023.1|2086601_2087021_-|peptidoglycan-binding-protein
MGGPVTHRRRAFALLTASAALLAGAVTAAPAATAAPTAAAAPKKCYTQSTIGLTCHHHYGAKWAEYGSTGAHVKEIQALINGTTTYYGTHGKALAVDGIYGAGTRSAVRWFQQKYIGASAVDGIVGPRTWDALRGFGRK
>NZ_CP016824.1|WP_079165318.1|2087166_2088363_-|serine-hydrolase
MAAPTAPPRPARRHRRPARLAAALATATALATLTPAPLAAASTTPGHEGTQRVLDTAVADGVPGALARARDRHGVWNGTAGTADLDTGRARGADDRFRIGSVTKTFVATVLLQLQGERRIDLDDTVDQHLPGLVDGHGHDGTAITLRQLLNHTSGISNYTADPEFRRRAFGEEFLDHRYDTWKPGQLVAVAMRHAPDFAPGTSWNYSNTNYILAGMVIEKVTGHGWEKEVERRILRPLGLRATSAPRTDPHLPRPAGRAYSFLGDPDREHPYDVTELNPSQAGAAGAMISTTGDLDRFQRALLGGRLLPPAQLRQMTTTVEVHPSAPHVRYGLGLMRQTLSCGIRIMGHDGGIHGSATLAFTTRDTRHSYQANLNGEWSPSDPADAVALTEAEFCREG
>NZ_CP016824.1|WP_067418042.1|2088804_2092125_+|S8-family-serine-peptidase
MTSESPQAPISGARRAARVAVAAGLVAALCAGAPLPMAFAADEPATAPTVKSAADKLGSADAERLAEAKADGDKHVTMMIATQPGRTAEVAGKLKAVKGGSVGKTHDKLGYVRATVPTGQADAAIKAAAKLSAVHGIDLNQEIQLDDPTPSGDRAKGVKSAAADSDDFYGAPNAKTPAKNPFNPSFETGAVEFVEKNPKADGRGITIGILDSGIDLGHPALQKTTTGERKITDWVTATDPIVDGDQTWRPMVDAVSGPSFTYKGRTYKAPAGSYQVSVFAEAASKGGDADGDLNRDGDTTDTWGVLYDAKNGTVRVDLNDNGDFTDDEVLRPYKDKFQVGYFGKDDPKTDVVEQIPFVVELRKGVPMDPYGGSWVGKKADFVNIGIIEGSHGTHVAGITAANSLFGGKMNGAAPGAKLVSSRACTWSGGCTSVALTEGMIDLAANRGVDIINMSIGGLPALNDGNNARAELYTRIIDAFGVQLVISAGNSGPGANTIGDPSLADKVISVGATISKETWLANYGSEVRKPYAMMPFSSRGPREDGGFTPTLSAPGAAINTTQTWFPGGPTLEAGYDLPAGYSMLQGTSMASPQAAGASALLLSKAKQQGIDLTPAKLRSALTSTATQIDGVQAYEQGAGLINIVDAWKQINKQDGDTHEYTVRAPVDTAIDELLKDPGHGTGVYDREGGLKVGKKRLYDITVTRTTGPKKAVSHKLALVNNHDETFKLVGGKKVDLKLNKPVTLTVSAKAATKGLHSAILTVDDPSTQGTDQQIMTTVVAADELAKPSFTVKKSGEVDRNETRSYFVEVPEGAKSLEVSLGGLFGKSQVRFISIHPYGVPVDSTSTPNCYNNYNNGNGCRPDLRSYADPAPGVWEIEVEARRTSPLLRNPYQLEVSLLGVAFDPAVQTVPEAKVGTPAPVEWKITNENAALEGKLKGGPLGSSLSKRPEIKNGEAQTTEITVGEGVERLDVAIGNVSDVAADLDLTLYDEQGNQVAQTADGDSEEALSVAKPKPGTYTVEVYAYSVPSGSTAYDYRDVYFSAALGEVKVDTAKTVKLATGASAKIAAEVLVAAPAPEGRKFFGQVQVLNAKGTAAGSGSVEIGKVTE

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Crispr_ID: NZ_CP016824_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_6

2105635-2105737

TypeII

Consensus_repeat	Method
AGCCCGGCCGGCGATTGAGGCCA	CRISPRCasFinder

1 spacers

Cas9_archaeal

The CRISPR arrays of NZ_CP016824_6

>merge|NZ_CP016824|6|2105635-2105737|CRISPRCasFinder
AGCCCGGCCGGCGATTGAGGCCAGTCGGGGGCCGGCGCGGGCAACATCCGGCGCCCCTAGTCGCGGCGCAGCCACATCCCAGCCCGGCCGGCGATTGAGGCCA

>NZ_CP016824|6|6|2105635-2105737|CRISPRCasFinder
AGCCCGGCCGGCGATTGAGGCCA	GTCGGGGGCCGGCGCGGGCAACATCCGGCGCCCCTAGTCGCGGCGCAGCCACATCCC
AGCCCGGCCGGCGATTGAGGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_079165319.1\|2099736_2100564_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412046.1\|2118980_2119958_+\|ATPase	unknown	unknown	gnl\|CDD\|225518
NZ_CP016824.1\|WP_003948082.1\|2108377_2108728_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412041.1\|2109079_2112139_+\|hyaluronidase	unknown	unknown	gnl\|CDD\|369423
NZ_CP016824.1\|WP_059213924.1\|2099062_2099542_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412034.1\|2098389_2098920_-\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|379311
NZ_CP016824.1\|WP_008408049.1\|2115093_2116158_+\|mechanosensitive-ion-channel-family-protein	unknown	unknown	gnl\|CDD\|366370
NZ_CP016824.1\|WP_067412042.1\|2114119_2114698_-\|HNH-endonuclease	Cas9_archaeal	cas9_archaeal	gnl\|CDD\|224321
NZ_CP016824.1\|WP_003948072.1\|2097697_2097991_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412043.1\|2116362_2117652_+\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NZ_CP016824.1\|WP_010637942.1\|2105830_2106028_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_018468136.1\|2092461_2093490_+\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NZ_CP016824.1\|WP_067412028.1\|2098021_2098375_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067418045.1\|2112154_2113645_-\|PHB-depolymerase-family-esterase	unknown	unknown	gnl\|CDD\|273828
NZ_CP016824.1\|WP_067412037.1\|2106081_2108376_-\|4-alpha-glucanotransferase	unknown	unknown	gnl\|CDD\|376788
NZ_CP016824.1\|WP_003948070.1\|2096303_2097464_-\|allantoicase	unknown	unknown	gnl\|CDD\|237319
NZ_CP016824.1\|WP_008414245.1\|2103746_2104658_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NZ_CP016824.1\|WP_030771516.1\|2117724_2118990_+\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|133432
NZ_CP016824.1\|WP_067418042.1\|2088804_2092125_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173796
NZ_CP016824.1\|WP_067412026.1\|2093639_2096216_+\|aminopeptidase-N	unknown	unknown	gnl\|CDD\|274121

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067412046.1\|2118980_2119958_+\|ATPase	gnl\|CDD\|225518	COG2971, COG2971, Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism].	7.98991e-21
NZ_CP016824.1\|WP_067412026.1\|2093639_2096216_+\|aminopeptidase-N	gnl\|CDD\|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0
NZ_CP016824.1\|WP_008408049.1\|2115093_2116158_+\|mechanosensitive-ion-channel-family-protein	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	2.4533e-38
NZ_CP016824.1\|WP_067418045.1\|2112154_2113645_-\|PHB-depolymerase-family-esterase	gnl\|CDD\|273828	TIGR01840, poly3-hydroxybutyrate_depolymerase_A_precursor, esterase, PHB depolymerase family. This model describes a subfamily among lipases of the ab-hydrolase family. This subfamily includes bacterial depolymerases for poly(3-hydroxybutyrate) (PHB) and related polyhydroxyalkanoates (PHA), as well as acetyl xylan esterases, feruloyl esterases, and others from fungi. [Fatty acid and phospholipid metabolism, Degradation].	8.40131e-74
NZ_CP016824.1\|WP_067412034.1\|2098389_2098920_-\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|379311	pfam13646, HEAT_2, HEAT repeats. This family includes multiple HEAT repeats.	0.000234659
NZ_CP016824.1\|WP_030771516.1\|2117724_2118990_+\|6-phospho-beta-glucosidase	gnl\|CDD\|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_CP016824.1\|WP_067412042.1\|2114119_2114698_-\|HNH-endonuclease	gnl\|CDD\|224321	COG1403, McrA, Restriction endonuclease [Defense mechanisms].	4.70247e-21
NZ_CP016824.1\|WP_018468136.1\|2092461_2093490_+\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NZ_CP016824.1\|WP_067412043.1\|2116362_2117652_+\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	4.77404e-32
NZ_CP016824.1\|WP_067412037.1\|2106081_2108376_-\|4-alpha-glucanotransferase	gnl\|CDD\|376788	pfam02446, Glyco_hydro_77, 4-alpha-glucanotransferase. These enzymes EC:2.4.1.25 transfer a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan.	2.88755e-160
NZ_CP016824.1\|WP_003948070.1\|2096303_2097464_-\|allantoicase	gnl\|CDD\|237319	PRK13257, PRK13257, allantoicase; Provisional.	1.10439e-166
NZ_CP016824.1\|WP_008414245.1\|2103746_2104658_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.29595e-45
NZ_CP016824.1\|WP_067418042.1\|2088804_2092125_+\|S8-family-serine-peptidase	gnl\|CDD\|173796	cd04857, Peptidases_S8_Tripeptidyl_Aminopeptidase_II, Peptidase S8 family domain in Tripeptidyl aminopeptidases_II. Tripeptidyl aminopeptidases II are member of the peptidase S8 or Subtilase family. Subtilases, or subtilisin-like serine proteases, have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure (an example of convergent evolution). Tripeptidyl aminopeptidase II removes tripeptides from the free N terminus of oligopeptides as well as having endoproteolytic activity. Some tripeptidyl aminopeptidases have been shown to cleave tripeptides and small peptides, e.g. angiotensin II and glucagon, while others are believed to be involved in MHC I processing.	1.15162e-63
NZ_CP016824.1\|WP_067412041.1\|2109079_2112139_+\|hyaluronidase	gnl\|CDD\|369423	pfam07555, NAGidase, beta-N-acetylglucosaminidase. This family has previously been described as a hyaluronidase. However, more recently it has been shown that this family has beta-N-acetylglucosaminidase activity.	2.74073e-138

>NZ_CP016824.1|WP_008414245.1|2103746_2104658_-|LysR-family-transcriptional-regulator
MAPPAPEWDLRKLRILRALHQHGTVTATAEALLMAPSAVSQQLSNFARQLGVPLLEAHGRRVRLTDAAHLVLHHADEVFAQLERADADLAALVRGDAGQVRIGAFSTAVAALVVPLVTRLREEAPGLELRVREAEAGEAYDLLAAGEVDLALSLAAHAPTVRDPRFTRVPLLADPLDVALPSAHPLAGAPDLRLADLAADPWIYGADGPWSDITRAACEAAGFRPEQAHTATGWPAILALVGAELGVALVPRMVSAEYTPGSVVVRPLEADRPRRHVIAAVRRGAEQGGGPVARVLAALRAGA
>NZ_CP016824.1|WP_079165319.1|2099736_2100564_-|hypothetical-protein
MRSPKRGPVAAPWLLFYSRYAGFMDMNGDKLNPGAIIDLTNWAELENADGSAFPVTPAKLHDLTSGDFLKVTSSLSHLYHALLNDGVVYSATAPAFRYVAALLGDRESRAALTPSWDGDKFPLRGKLLSWLADVAFDVSIEHEQRIREWGGYSPTEPFPDFLNIRSIYPEAFPGVASYFDDLDPRVVEAALVAAVRFLESPALAVHRGRLTFLLENVLAQSSSERHRSLASEALASWEQGRVLMEPFTDPHPSEEHGKDHRHSHGKRGSVDEPPF
>NZ_CP016824.1|WP_059213924.1|2099062_2099542_-|hypothetical-protein
MVEAECMTDGSSYGSRPEYLPDFMNDPHDDDGRQVVKLDLAENRALAAATLSRFPAATGDVIDFESTPFEGRLWWDDEEHWTRMAADLLSSHVQRGERIAVIWGNYLMPVVTMPADVAVRRARDILDAGPHFWMHPLGGSVLIECLMDGQVTVATIPSS
>NZ_CP016824.1|WP_067412034.1|2098389_2098920_-|HEAT-repeat-domain-containing-protein
MKPEDQRAILDLVTYPGSAPRGTPEEVLRHFGTDDGRALGLELLREAVAERDGDQVEMALIVTDRFGLSPACLEPLITLCSADWHHAHEGVVSALGTLRSPASVRALQHLADWVPDYLDYDDSRAMGVKAVWALRRTPGPEAEEALRGLLASGSDIVREAAAKGLRSRGVSESEGT
>NZ_CP016824.1|WP_067412028.1|2098021_2098375_-|hypothetical-protein
MELPVREEELQEIEELCSAATPGPWHARALDDDSAMNLVAVSTVPGGGAAGRWPDFDHRDLVAATLVQHPRYVDVGDERWDENAAFIAMAREAVPRLVEEVRRLRALLADEGEGVSA
>NZ_CP016824.1|WP_003948072.1|2097697_2097991_-|hypothetical-protein
MAAEEFGLRVASYGPLVGVRDDPSHTRARACVGPLIDSGRLDREGLHLVMPMVRNGVPPAGEEPSYRCYLWFLERGRGERTLVLVDVSERRLKARAR
>NZ_CP016824.1|WP_003948070.1|2096303_2097464_-|allantoicase
MTTHPATPDSQDAHADDPHANDAAPYPGGDPYGDYRTHGVDFSATDLVDLADRRLGAGVIAANDEFFAQRENLLVRERAVFDPEHFGHKGKVMDGWETRRRRGAGPETPFPAPEEHDWALIRLGAPGVVKGVVVDTAHFRGNYPQRVSLQATAVEGNPGPEELLASDVKWEELLPPTPVLGHAANGFAFDVERRFTHLRLCQHPDGGIARLRVYGEVVPDPEWLGLLGTVDLAAVLNGGVYEDASDRFYSSPTQIIQPGTSRKMDDGWENRRRRVRDTNDWVRFRLAAQGVIRAVEIDTAYLKGNSAGWVALSARDGEDGEWYEILPRTRLQPDTPHRFRLATPATATHVRLDAFPDGGVARMRLHGELTEAGAAALADRYRRLAG
>NZ_CP016824.1|WP_067412026.1|2093639_2096216_+|aminopeptidase-N
MPGTNLTREEAQERARLLTVDAYEIELDLSGAQDGGTFRSVTSVRFDSAEAGASTFVDLIAPAVHEVVLNGTALDVAAVFRDSRIALDGLLQGRNELRVVADCAYTNTGEGLHRFVDPVDEQAYLYTQFEVPDSRRVFAVFEQPDLKGTFTFTVTAPSGWTVISNSPTPEPDGDVWKFEPTPRISSYITALIAGPYHAVHSVYEKDGQRVPLGIYCRPSLAEHLDAEHIFDVTRQGFDWFQEKFDYAYPFAKYDQLFVPEFNAGAMENAGAVTIRDQYVFRSKVTDAAYERRAETILHELAHMWFGDLVTMEWWNDLWLNESFATFTSVACQAAAPGSRWPHSWTTFANAEKTWAYRQDQLPSTHPIMAEINDLDDVLVNFDGITYAKGASVLKQLVAYVGEDAFFAGVQAYFKQHAFGNTKLTDLLGALEKTSGRDLTTWAQKWLQTAGINVLRPEITTDADGTVTSFAVRQTAPALPAGAKGTAVLRPHRIAIGSYDLDDAGRLVRTGRIELDVDGELTEVPELVGTGRPAVFLLNDDDLSYAKVRLDEDSLAVVTAHLGDFAESLPRALSWASAWDMTRDGELATRDYLDLVISGIPKESDIGVVQSLQRQVHMAIEQYADPAWRPEGLARWTEFALEQLRAAAPGSDHQLAWARAFADTARTDTQLDLLEALLDGGETIEGLAVDTELRWALLHRLAATGRADEGAVDAELARDRTAAGERHAASARSARPTEEAKATAWASVVESDKLANAVQEAVIGGFVQYDQRELLAPYTAKYFAAVKDVAAGRSHEMVQQIVVGLYPALQISQETLDATDAWIAANDPTPGLRRMITECRAGVERALRAREADAAAGRA
>NZ_CP016824.1|WP_018468136.1|2092461_2093490_+|aspartate-semialdehyde-dehydrogenase
MRVGIVGATGQVGTVMRRILAERNFPVSELRLFASARSAGSTIEWQGSEVTVEDASTADYSGLDIVLFSAGGATSRALAEKVAAQGPVVIDNSSAWRRDPEVPLVVSEVNPHAIADRPKGIIANPNCTTMAAMPVLRPLHDEAGLEALVVATYQAVSGSGLAGVAELHGQTQKVVAEADQLTHDGAAVDFPEPGVYARPIAFNVLPLAGSVVDDGSFETDEEQKLRNESRKILEIPELKVSGTCVRVPVFSGHSLQINARFARPLGVERATELLKGAEGVELSEIPTPLQAAGQDPSYVGRIRVDETVENGLSLFVSNDNLRKGAALNAVQIAELVAAELKG
>NZ_CP016824.1|WP_067418042.1|2088804_2092125_+|S8-family-serine-peptidase
MTSESPQAPISGARRAARVAVAAGLVAALCAGAPLPMAFAADEPATAPTVKSAADKLGSADAERLAEAKADGDKHVTMMIATQPGRTAEVAGKLKAVKGGSVGKTHDKLGYVRATVPTGQADAAIKAAAKLSAVHGIDLNQEIQLDDPTPSGDRAKGVKSAAADSDDFYGAPNAKTPAKNPFNPSFETGAVEFVEKNPKADGRGITIGILDSGIDLGHPALQKTTTGERKITDWVTATDPIVDGDQTWRPMVDAVSGPSFTYKGRTYKAPAGSYQVSVFAEAASKGGDADGDLNRDGDTTDTWGVLYDAKNGTVRVDLNDNGDFTDDEVLRPYKDKFQVGYFGKDDPKTDVVEQIPFVVELRKGVPMDPYGGSWVGKKADFVNIGIIEGSHGTHVAGITAANSLFGGKMNGAAPGAKLVSSRACTWSGGCTSVALTEGMIDLAANRGVDIINMSIGGLPALNDGNNARAELYTRIIDAFGVQLVISAGNSGPGANTIGDPSLADKVISVGATISKETWLANYGSEVRKPYAMMPFSSRGPREDGGFTPTLSAPGAAINTTQTWFPGGPTLEAGYDLPAGYSMLQGTSMASPQAAGASALLLSKAKQQGIDLTPAKLRSALTSTATQIDGVQAYEQGAGLINIVDAWKQINKQDGDTHEYTVRAPVDTAIDELLKDPGHGTGVYDREGGLKVGKKRLYDITVTRTTGPKKAVSHKLALVNNHDETFKLVGGKKVDLKLNKPVTLTVSAKAATKGLHSAILTVDDPSTQGTDQQIMTTVVAADELAKPSFTVKKSGEVDRNETRSYFVEVPEGAKSLEVSLGGLFGKSQVRFISIHPYGVPVDSTSTPNCYNNYNNGNGCRPDLRSYADPAPGVWEIEVEARRTSPLLRNPYQLEVSLLGVAFDPAVQTVPEAKVGTPAPVEWKITNENAALEGKLKGGPLGSSLSKRPEIKNGEAQTTEITVGEGVERLDVAIGNVSDVAADLDLTLYDEQGNQVAQTADGDSEEALSVAKPKPGTYTVEVYAYSVPSGSTAYDYRDVYFSAALGEVKVDTAKTVKLATGASAKIAAEVLVAAPAPEGRKFFGQVQVLNAKGTAAGSGSVEIGKVTE
>NZ_CP016824.1|WP_010637942.1|2105830_2106028_-|hypothetical-protein
MVAGTTLTTLLMTSPALALTRDDGDDPGPGLSVVETLGLYVALPIVLFLVIAGLVMVMDKSGKRS
>NZ_CP016824.1|WP_067412037.1|2106081_2108376_-|4-alpha-glucanotransferase
MALSRLAELHGVATSYSPSPDRTVPAAESAVVAALAALGVDASSPEAIRAALEKAEAGQAARLLPPTVVLRSAAPSADPRTAPELAALPPRTRVRLTRDPDPVPARPAPAGGRDAGEAVRRAAPVGEAPPPAWNWTVPLVPAATAPPPPAGSALPPAADVLWAVPFGVHRIEATTPDGRTATSHLVIAPDHIRGPESRAWGLLVQLYSLLSHRSWGMGDLGDLAELATWAGRVHGAGFVQVNPLHAAVPGTPTDPSPYRPSSRRFPDPVHLRVEAIPEYTALSADVRPHLDGLLRRAAELRVRVLSGEALIDRDAVWELKREALERLCAVPLPPGRQAAYEDFTAAHGQALTDHATWAALTERHGPHWSEWPAPLTDPRSRQTAAARTELAARVDFHRRLAWYTDTQLAEAQRAAREAGMAVGLVHDLAVGVHPDGSDAWSQQDVFAAGMSVGAPPDAFNALGQDWGLPPWRPDSLAESGYAPYRGLLRSLLRNAGALRIDHVMGLFRLWWVPVGAPPTDGTYVHYDAEAMLAVLALEAHRADAVVIGEDLGTVEPGVRETLQRHGVLGTSVLWFERDWDGTGLPLPAEAWRASCVATATTHDLPSTASRLTGDHVRLRHRLGLLTRPLAEEEAEEAAATATWLTVLDGLGLMGAAPGGHLPGAAPDEEAAVLAVHRFLLRTPARMIGVWLPDGTGDRRPQNLPGTWDQYPNWRLPVADAQGHPVTLEQLTASPRVARLLRTVATEDQTPAPMVRTAPPDARPV
>NZ_CP016824.1|WP_003948082.1|2108377_2108728_-|hypothetical-protein
MAASAHLLLSALSKRPELHDLPAIPSPTTLAGRPDDPFDPDTVDYSLVSHPDSGLEGSCAYGLSEPPLTSEPPLADAAPLTSEPPLPDTAPLTSEPAAAAAVVAEDALLGAVSSGG
>NZ_CP016824.1|WP_067412041.1|2109079_2112139_+|hyaluronidase
MQLRRSRTAAALAVAVIAGTLGGAPTALAAPPAPDPATAADEAPDDAKGETTGLPSVWPRPQSLRAADGKVALGSRVVLVAPLGTDPYALKALREVLREAGVRDVDEVSAEGDVPAGATPVVRVGGESAARPGAGGAGLEKTLRALGASARGDLPQGGYRLAAGQAGGRPTVAMAGVGEDGLFHAVQTLRQLVRDGVVPGVVVRDWPGTPVRGLSEGFYGTPWTTEQRLGQLDFLGRTKQNHYLYAPGDDLFRQARWREPYPAGQRAAFRALAERARENHVTLAWAVAPGQAMCLASEDDVKALNRKIDAMWALGARAFQLQFQDVSYSEWHCGEDEAEFGSGPAAAARAQARVANAVAAHLAERHPGSRPLSLMPTEYYQKGATEYRRKLAAELEADVQVAWTGVGVVPRTITGRELAGTREVLGHPLVTLDNYPVNDYAQDRIFLGPYTGREPAVATGSAALIATAMEQPAASRIPLFTSGDYAWNPKDYRPMESWQAAMDTLAGEDPETREAVRALARNTASSVLGADESAYLRPLLAKFWATRADAARAAGRPGTEAADAAARAAKELRAAFSVMRATPERLDGGGSGLGEEVRPWSEQLARFGHAGELAVDLLAAQARGDGTAAWHAERALRAVRAETSRNKVTVGDGVLGPFLDQVEKTADSWHGTVGGDGEKVADTGSAYTVALPRVRPLAGVTVRTDPGVSGLVEARVPGKGWQPVTRLEPGGWTDVESRGLRADALRVTGPEAERVDRLVPWYEDGAEAALRLGRGEADAEIGGGTSEVTARLTAHRPGTVRGALKAKTPKGIQVSPPGESVLPRGTEVRIPVSVRVADGVRPGSYEVPVEFGGRSATLTVRAFPPTDDRDLVRSGKATSSADETEDFPARAAADGDPESRWSSPAEDNAWWQTELPEPARVGRVELHWQDAYAAAYRVQVSEDGRIWRTAATVKDGKGGRERVGLDAKNVRFLRVQGDKRATEYGYSLFSVEAYAVTEKEKSKDKGKGDGKAEEKPGRD
>NZ_CP016824.1|WP_067418045.1|2112154_2113645_-|PHB-depolymerase-family-esterase
MVTLAGVAGPESVTAPARAASLTEVTGFGSNPGNLRMFRYVPDGLPAGRPLVVAMHGCTQSAGGFDDETGWTKWADQWGFALVLPQQQSANNLNSCFNWFEAGDIRRDAGEALSIKQMTDRMKADVGSDPARVHATGLSAGAAMTNVMLAAYPDVFASGAPVAGLPYACATSVVAAYSCMNPGSNLTPAAWAAKVRDAYPGYAGPWPAVSVWQGTTDTTVVPANLTETVEQWTAVHGTDTTPDATGTVGGYPHAVYRDGDGRDVVETHTITGMGHGQPVDPGSGAEQCGTAGAYILDVNICAAYHIGRFWGLAEDGGGTDPGTPAQRAVIPSTAADDGYVKASASGTGAAVGALEGTMGAAVGRGTDGQHNRTLLSFDTSAVPDDATITRAYVTVSRASGSGDPWAGGNRLLMDVRSGCFGASCATAADDWAAPATTSGAAELARFTSGSADSTAFTEVNRTGPTQLRLRLADAPASTAYLFLRTGAEAKLTVEWE
>NZ_CP016824.1|WP_067412042.1|2114119_2114698_-|HNH-endonuclease
MPHVLVLNASYEPLGVVPLRRALVLVLESKAVCLEESGAFLHSESRTVPAPSVVRLKRFVKVPYRGAVPLTRRALFARDGGRCVYCGGVATSVDHVIPRSRGGLHVWDNVVASCRRCNHVKADRHLMELGWRLRNKPAPPTGLAWRIIGTGHRDPRWLPYLQPFGGDDALARIENVGGGGEAVAVRPARAGA
>NZ_CP016824.1|WP_008408049.1|2115093_2116158_+|mechanosensitive-ion-channel-family-protein
MFPSAPAAGREDTVTLEEAQERATDAAGWVSENWSTWLETGLRILLIIVVAAALRMVIRKTITNLIDRMNRTASAVDGTALGGLLVNAERRRQRSQAIGSVLRSVASFLIVGTAALMILDTFKINLAPLLASAGVAGVAIGFGARNLVTDFLSGVFMILEDQYGVGDTIDAGVATGEVVEVGLRVTKLRGPNGAVWYVRNGEVKRIGNLSQGWSTAAVEVTVRSDEDLDKVRDTLTEVGAQIAKDEPWNERLWGPVEVLGLDSVLLDSMVVGVSAKTMPGQDVAVERELRWRIKKAFDAAGISIVGGPAELAEEDAADPSAGMAAPSAYASATSPQSLAASPIPPPASGPRLGK
>NZ_CP016824.1|WP_067412043.1|2116362_2117652_+|ROK-family-transcriptional-regulator
MVAGTPPVLRVMNERATLDLLTEHGALSRARIGALTGLSKPTVSQLLARLEAAGLVGPAGTSEGRPGPGARLYALRGEVAYVAALDVRPGRIRAAVADVTGTVLATHTLATPARPGPGGVPAQLTAALDGAARAAGTERPALRRVVVGTPGAFDPRTGRLRYAGHLAGWHSPGLLAEVAAALHPVPVEYENDVNLAAVAERRLGAARGHEDFVLLWNGTGLGAALVIGGRLHRGWTGGAGEIGFLPVAGTPLVRGVARTGSGGFQELAGAQALPRLAGELGVAVPQAGPEGADPADGEAVAAALLRTAAEAYTRPGGDPAPGAAEPPHEGTSSPHAGPAALLRAYAVRLATGIASLVAVLDPAVIVLTGRVLAAGGEPLLRLTEAELAELAPSRPRLLAGEVTGDPVVRGGLEAALTTVRDEVFDTAAL
>NZ_CP016824.1|WP_030771516.1|2117724_2118990_+|6-phospho-beta-glucosidase
MKLTVVGGGSTYTPELIDGFARLRDTLPLTELVLVDPDAGRLELVGGLARRIFARQGHPGTITTTGDLDAGVEGADAVLLQLRVGGQAARQRDESWPLECGCVGQETTGAGGLAKALRTVPVVLDIAERVRRTNPDAWIIDFTNPVGIVTRALLQAGHKAVGLCNVAIGFQRKFARLLDVAPAEVHLGHVGLNHLSWETSVRLGGPTGEDVLPRLLTEHGDAIAADLHLPRPLLDRLGVVPSYYLRYFYAHDVVVDELRTGPSRAEKVAAMERELLELYADPALDEKPELLSQRGGAFYSEAAVDLAAALLGRGGSPLQVVNARNDGTLPFLPDDAVVEVQAEVGPEGARPLAVPALDPLYAGLVQHVTAYEDLALRAALEGGRDRVFAALLAHPLIGQYDQAETLTDLLLSHNQEHLPWA
>NZ_CP016824.1|WP_067412046.1|2118980_2119958_+|ATPase
MGLSGAVLAIDAGNSKTDVAVVTADGEVAGTARGGGFRPPATGVEAAVDTLAEAVARAQEAAGHLPVAQVSACLANADLPVEEEQLSAAIAARGWGASVEVRNDTFAVLRAGLLEDAAPRGVAVVCGAGINCAGMLPDGRTARFPALGRVSGDWGGGGGLAEEALWHAARAEDGRGAPTELARALPEHFGLGSMYALIEALHLGHVPAGRRHELTPVLFTVAEAGDPVASGLVDRLADEVANMAAVALGRLGLLDSPAPVLLGGSILAARRPGLDAGVRGELGRRAPLAEVRVVEAAPVLGAVLLGMDAVGAGVGAYERVRGWFG

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Crispr_ID: NZ_CP016824_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_7

2166951-2167162

Orphan

Consensus_repeat	Method
GGGACCACCCCCGCACACGCGGGGAGCAC	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP016824_7

>merge|NZ_CP016824|7|2166951-2167162|CRISPRCasFinder
GTGAGTTGCCCTGCGGGCGCGGGGAGCACAACCCCATCAAGCTGAGCGACGTCGACCCGACGGGACCACCCCAGCACACGCGGGGAGCACCGCTGGCTGCTCGACCCGCAGGCGACGGCGAAGGGACCACCCCCGCACACGCGGGGAGCACACGCCGGCGGCGACCGCGCAGGTTTCGCCTTGGGGACCACCCCCGCACACGCGGGGAGCAC

>NZ_CP016824|7|7|2166951-2167162|CRISPRCasFinder
GTGAGTTGCCCTGCGGGCGCGGGGAGCAC	AACCCCATCAAGCTGAGCGACGTCGACCCGAC
GGGACCACCCCAGCACACGCGGGGAGCAC	CGCTGGCTGCTCGACCCGCAGGCGACGGCGAA
GGGACCACCCCCGCACACGCGGGGAGCAC	ACGCCGGCGGCGACCGCGCAGGTTTCGCCTTG
GGGACCACCCCCGCACACGCGGGGAGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_008406989.1\|2164807_2165215_+\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP016824.1\|WP_067412109.1\|2167626_2169741_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|315987
NZ_CP016824.1\|WP_030308929.1\|2161347_2162181_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349980
NZ_CP016824.1\|WP_003948132.1\|2174214_2174874_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP016824.1\|WP_015507868.1\|2158424_2159639_+\|CapA-family-protein	unknown	unknown	gnl\|CDD\|378215
NZ_CP016824.1\|WP_067412100.1\|2157487_2158117_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412125.1\|2181108_2182995_-\|3D-(3,5/4)-trihydroxycyclohexane-1,2-dione-acylhydrolase-(decyclizing)	unknown	unknown	gnl\|CDD\|275170
NZ_CP016824.1\|WP_049978881.1\|2162682_2163567_-\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|371292
NZ_CP016824.1\|WP_067412113.1\|2171616_2173374_+\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|379231
NZ_CP016824.1\|WP_026235013.1\|2160060_2161182_-\|DUF91-domain-containing-protein	unknown	unknown	gnl\|CDD\|224552
NZ_CP016824.1\|WP_067412104.1\|2163563_2164475_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP016824.1\|WP_067412095.1\|2153090_2157422_+\|Secreted-glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|271156
NZ_CP016824.1\|WP_067412121.1\|2178921_2179524_-\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|377593
NZ_CP016824.1\|WP_067412115.1\|2173389_2174127_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003948122.1\|2162192_2162552_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412107.1\|2165367_2166921_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|312032
NZ_CP016824.1\|WP_067412112.1\|2169744_2171499_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412118.1\|2175845_2178515_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|213235
NZ_CP016824.1\|WP_037844162.1\|2174970_2175849_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224196
NZ_CP016824.1\|WP_030770989.1\|2179594_2181094_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143404

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_008406989.1\|2164807_2165215_+\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	3.88073e-08
NZ_CP016824.1\|WP_067412109.1\|2167626_2169741_+\|hypothetical-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	0.000135997
NZ_CP016824.1\|WP_030308929.1\|2161347_2162181_+\|RNA-methyltransferase	gnl\|CDD\|349980	cd18107, SpoU-like_AviRb, SAM-dependent rRNA methylase related to AviRb. AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	3.04678e-82
NZ_CP016824.1\|WP_003948132.1\|2174214_2174874_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	2.33263e-37
NZ_CP016824.1\|WP_015507868.1\|2158424_2159639_+\|CapA-family-protein	gnl\|CDD\|378215	pfam09587, PGA_cap, Bacterial capsule synthesis protein PGA_cap. This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.	4.5171e-78
NZ_CP016824.1\|WP_067412125.1\|2181108_2182995_-\|3D-(3,5/4)-trihydroxycyclohexane-1,2-dione-acylhydrolase-(decyclizing)	gnl\|CDD\|275170	TIGR04377, 3D-35/4-trihydroxycyclohexane-12-dione_hydrolase, 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase. Members of this protein family, 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (iolD), represent one of eight enzymes in a pathway converting myo-inositol to acetyl-CoA. IolD hydrolyzes the cyclic molecule 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione to yield 5-deoxy-D-glucuronic acid. TPP is a cofactor. [Energy metabolism, Sugars].	0
NZ_CP016824.1\|WP_049978881.1\|2162682_2163567_-\|XRE-family-transcriptional-regulator	gnl\|CDD\|371292	pfam10901, DUF2690, Protein of unknown function (DUF2690). This bacterial family of proteins has no known function.	7.74192e-13
NZ_CP016824.1\|WP_067412113.1\|2171616_2173374_+\|FUSC-family-protein	gnl\|CDD\|379231	pfam13515, FUSC_2, Fusaric acid resistance protein-like.	4.79584e-17
NZ_CP016824.1\|WP_026235013.1\|2160060_2161182_-\|DUF91-domain-containing-protein	gnl\|CDD\|224552	COG1637, COG1637, Predicted nuclease of the RecB family [DNA replication, recombination, and repair].	2.07264e-06
NZ_CP016824.1\|WP_067412104.1\|2163563_2164475_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	2.8674e-15
NZ_CP016824.1\|WP_067412095.1\|2153090_2157422_+\|Secreted-glycosyl-hydrolase	gnl\|CDD\|271156	cd14490, CBM6-CBM35-CBM36_like_1, uncharacterized members of the carbohydrate binding module 6 (CBM6) and CBM35_like superfamily. Carbohydrate binding module family 6 (CBM6, family 6 CBM), also known as cellulose binding domain family VI (CBD VI), and related CBMs (CBM35 and CBM36). These are non-catalytic carbohydrate binding domains found in a range of enzymes that display activities against a diverse range of carbohydrate targets, including mannan, xylan, beta-glucans, cellulose, agarose, and arabinans. These domains facilitate the strong binding of the appended catalytic modules to their dedicated, insoluble substrates. Many of these CBMs are associated with glycoside hydrolase (GH) domains. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold. CBM36s are calcium-dependent xylan binding domains. CBM35s display conserved specificity through extensive sequence similarity, but divergent function through their appended catalytic modules.	1.14352e-65
NZ_CP016824.1\|WP_067412121.1\|2178921_2179524_-\|nucleotidyltransferase-family-protein	gnl\|CDD\|377593	pfam06042, NTP_transf_6, Nucleotidyltransferase. This family consists of several hypothetical bacterial proteins of unknown function. This family was recently identified as belonging to the nucleotidyltransferase superfamily.	1.51548e-75
NZ_CP016824.1\|WP_067412107.1\|2165367_2166921_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	2.41284e-05
NZ_CP016824.1\|WP_067412118.1\|2175845_2178515_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	5.46204e-81
NZ_CP016824.1\|WP_037844162.1\|2174970_2175849_-\|ABC-transporter-permease	gnl\|CDD\|224196	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only].	3.3893e-05
NZ_CP016824.1\|WP_030770989.1\|2179594_2181094_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	gnl\|CDD\|143404	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2. Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.	0

>NZ_CP016824.1|WP_067412107.1|2165367_2166921_+|alpha/beta-fold-hydrolase
MGGARSRGVRTVAGVVLAGLLAAACADGDVRPQAAATGTPPRTGELTWGTCPEPSEAEAQVWGAAEHRPAYARHAARLRCGTLTVPADWTAPQGRRLELAVALLPSTGDGPAEPLALNPGGPGVSGRLMPIGIASGGARALLDRYDLVGLDVRGTGRSGPATCPAAESLDAGPQPAAPTPRTARAYWNRLARAHTTCAEADPAQLASLTTTNAAHDLDALRRALRAPRLHYYGVSWGTSLGATYRTLFPTHSGRTLLESVVSPDPDLRGLLDGVTRAREQRFEHFTAWLAARSDRYGLGITADEVRTRLLSLRERLTTRPLRTSDGTYGRVETDQYLDSEPADRAGAGAALSSLARGRAPAGGGDGKPRAAAPPLVAPFAGTALLCSQVTHAASFAEQWSAYGERRTAYPVLGATRPMFPGSGEVPGTSTCAGLPAPERPPVEPGPADGPLLLVAHRDEVITPLPWARAMRARTGGWLLVVGEGEHGGMAGGGCAGRVVGFFAGEEGAAAEGGVCEP
>NZ_CP016824.1|WP_008406989.1|2164807_2165215_+|peptidoglycan-binding-protein
MRSRPYTRSVAAGVVAAAALALLPATTATAAPAPVAAAADTCRGVSTVGLHCGYSTSNAFAQRGSKGAHVKEIQALINETTIWPKQTGKRLTVDGDFGPTTESAVSWFQWYYGSEALSDGMVGPKTWEMLRYGKR
>NZ_CP016824.1|WP_067412104.1|2163563_2164475_-|helix-turn-helix-domain-containing-protein
MAPWKALPEHLDPQAGRLVDRLRRLKDATGLSFTALATRTSYSRSSWERYLNGRKLPPADAVTELAVLAGADPDRMLALHTLAAQTWTGPQPKDAATPGTSGAGPEPTEPEPEPDPGAAPEAAATAPAPAPAPAEPDAPAAVPPALIGEPDVPAEPVRARPARRTLLAVGGALVVVAAVLAVVVTLVLPGRGSAGAGEEKHRRTATEEFAFKPDRTYDCDIHRFEGRLYAGHSDTQDALLQQISTTWEVVEAQCLLEHRGYRIGGIDGAYGPATERAVKRLQDKEGLVVDGIMGPHTWEALRR
>NZ_CP016824.1|WP_049978881.1|2162682_2163567_-|XRE-family-transcriptional-regulator
MSDELTLECAHLARELAGLRATTGLSLAGLAARTTASKSSWQRYLGGTQIPPPELVTELCALAGEPPARLLALRELAELSRRHPQPRPAPPAPPASEEPSRKTGPATAEEPPAAGTPDTGRPHAPPPAAPASVPRPRRFLRRRKVALAGAGALATAAMVAGALLLGGAREEPEDIGVWPGCVGERCRGKQAQSQGCGLKGSGMRTVAEREYGRQTVVELRYSPTCRASWVRIRFGATGDRIEITGPDKESQSAEVADKFDAQNYLPTPMLAGGPEGMTACLVRADGGERHCFGQ
>NZ_CP016824.1|WP_003948122.1|2162192_2162552_+|hypothetical-protein
MSKTDALLVDLATLVESGRSNQMSLTVVTGGTVITGRLAPEAVWRERVSEVLADSAQLGAFSAVFTNERPADGPPRHLHFHVARILQGTVGIPETGGMYRVAIEDVSAWTVGDFSYSDN
>NZ_CP016824.1|WP_030308929.1|2161347_2162181_+|RNA-methyltransferase
MPSVQRVTSRNARFQQWEALLGNRKKRNQLREFLVQGVRPISLAVEYGWRVRALLYDDSRKLSGWAREVLGAVEGERVALAPELMAELGEKSGGAPEVVAVVEVPADDLERIEAGPEFLGVLFDRPTMPGNIGSIIRSADAFGAHGMIVSGHAADVYDPKSVRATTGSLFSLPTVRVPSPAEVMAWVERRRAAGLPLVLVATDEKGDADVYDFDFTQPVLLLVGNETSGLAGAWREVCDVTVSIPMAGAASSLNAANAATAVLYEASRQRAAARRAD
>NZ_CP016824.1|WP_026235013.1|2160060_2161182_-|DUF91-domain-containing-protein
MPLEFGLWRVDDKPVRVATRAMPLESRLEELIEADPGILGTPLLLLGRQVPTAYGKVVDLLGMDAEGGLHVLELKRDRTPREVVAQVLDYGSWVQGLTNEQIRDIYGAYARRRGLAEELDEAFALRFGGSPPEALNSTHSLTVLASEIDAATERIVGYLASGFQVPVNVLFFRYFEDEGRSYLARTWLIDDAEATAPSAGSKGRAKQEPWSGTDWYVSFGDEPGGRSWDDALRYGFVSAGSGEWFSRTIRSLPLGARVFTHIPRTGYVGVGTVSGEPQPFEDAVLTVDGARRRMADLPLEGAYRVAGEGAPGEGEDRREWIVPVTWGHAVPRESAFWRTGFFANQNSACKLRARFTIDEVSRHFGVVDDLEGA
>NZ_CP016824.1|WP_015507868.1|2158424_2159639_+|CapA-family-protein
MPSPHRRTLPRRTAALATALTLGALAAGCAEPGPPAPRPGAAAPPAPAPGRFTLVATGDILAHDAVIRQAAADASGVPDRDAGPDPFAPENDGRYDFAPMLAGARAVTTGADLAVCHLETIVGEDNGPFTGYPLFKTPPHIARAIRSTGYDTCSTASNHAMDDGEEGVRRTLDALDRADVAHTGTARAPEDRARPLLLRAGDARVAHLSYVHWTNKEVPPGKPYLVDQLDPDQVVADARAARAAGADVVIASVHWGTEWQEAPDRQQREVARQLTASRSQGRRDIDLILGTHAHVPQAYEKVNGTWVVYGMGDQVAGEMTDPRGQLGSAARFTFTEPREPGAAWQVTSAEYIPHRMANDPLRLVNLPRATERPAPDPEDTAALAAVRKAVLSRGADQDGLRMGR
>NZ_CP016824.1|WP_067412100.1|2157487_2158117_-|hypothetical-protein
MSKKKLWLRAAASAAVLTLALTGCGGSDEGDGATTDKGGSASQEQDKGQGEEQPEEEKGGGELAAGEKATSEFDEDGTKVTYEIAAQKVDVGTAEDTKKLVSDPKKAAGLVPAVAHVEFTVKDGGPVAEYPDAGREIEVYADGQRGTILIGASDDAPGCEKSTDVKDWKAGESHVFCDTYMVPEGAKELTVQWAADRDADPFIWTFENS
>NZ_CP016824.1|WP_067412095.1|2153090_2157422_+|Secreted-glycosyl-hydrolase
MKPARRRPPALSGRLPRPGRRTATALVTASLLLLGLPALPASAAGGPNAAAGAEARAGSAAPSHQAAHATDGDLATYWQGGSGKKSAQWVQTDLGKAQRVREVTLRLPAGWKEREQTIALQGSRDGESFATLKKEATYSFAPGSGNSVTVRFPATLARYVRADFRGNSVAGTGQLAELQVGTAAAATPNLAQGKPFTASSFTDVYPAPNAGDGNRATYWESRNNDLPQWAQVDLGSSVRVDRVVLRLPGGWPSRSQTLKIQGSTDGRSFTDLTAPRAYAFDAGNEQSATISFDATSTRYVRVLITANTGQPAGQLAELEVYGPATGDTQAPTAPTGLTLTEPATGQIRLAWRAASDDTGVTGYDVYADGQLRASVAGNVLTWTDTQPGDATVRYTVRARDAAGNVSGDSNAVTREGGSGDTQAPTAPTGLTHTQSGGDIRLSWRAATDNVKVTAYDVYADGQVVKSVGGDVLTWTDTGRPASQTVTYTVRARDAAGNTSPHSNAVTRAGSGGTGADLARGKPITASSTVHTFVAANANDGQTSTYWEGAGGSYPQTLTVKLGAGADVKQVVLKLNPDSAWGTRDQTVQVLGRAQDADGFTSAVAAKSYTFAPSSQNTVTIPVEGRFADVQLRFTANSGAPAGQLAEFEVHGVPAPNPDLKVTKITHSPAEPVESDRIDLTATVTNSGTEPAAATDLVFLLGGEKAGTADVPALAAGASRTVTGSVGSRDAGSYEVGAVVDESGKVTEQDEANNRYTSPDPLVVKPVASSDLVASPVSWSPSSASAGDTLTFSVAVKNQGTTASASGAHPVTLTVTDAKGSVVKTLTGAHNGAIAPGATTAPVRLGTWTAANGKYTVKTVIADDANELPVKRANNTSTEPLFVGRGADMPYTTHEAEDGTVGGGAKVVGPNRTVGDVAGEAGGRRAVTLTGNGQYVEFTTKAPTNTLVTRFSIPDNAAGTGTNATLNVYVDGQFLKALDLTSKYAWLYGNEAAPGNSPGSGAPRHIYDEASTLLGRTVPAGSVIRLQKDAANTASSYAIDFVDTEQATALPNPDPAAYTVPAGFSHQDVQDALDRVRMDTSGKLTGVYLPPGDYQTSSKFLVYGKKVDVVGAGGWFTRFHAPASQDNTDVGFRAEASAKGSSFANFAYFGNYTSRIDGPGKVFDFANVSDITIDGIWVEHMVCLYWGANTDRITIKNSRIRNLFADGVNMTNGSTHNHVVNNDARATGDDSFALFSAIDAGGADETDNVYENLTSTLTWRAAGLAVYGGYRNTFRNIHIADTLVYSGITVSSLDFGYPMNGFGTEPTTIENVSLVRTGGHFWGSQTFPGIWLFSASKVFQGIRINNVDIVDPTYSGIMFQTNYVGGQPQSPIKDTVLTDISITGAKKSGDAFDAKSGFGLWANELPEAGQGPAVGEVTINGLTLNGNHQNVKNDTSTFKININP
>NZ_CP016824.1|WP_067412109.1|2167626_2169741_+|hypothetical-protein
MGGDDAGVGAGVWNSVSGGTVFGAVVQAQRIDSLNVEAPPQVWPPRQLPPPLPGFVNRTKERRTLRELAEAAVGQGVRTVVVTGLGGVGKTQLIAHCVRSDLGAFFPDGQDVDLADVRRDGAVDVAGGLGDWLHAFGVPYGHQPAGLGGRADLFRTVTTGKRVLVVVDNVRQAPEIRALTPGDGLLVATSRTMLPALRMDGAVQLVVDPLDEREAIGIVRGWPVAQSEGPAAAELVRRCGGLPLALRAVGEWLVERPQLGLDDAVRSLAPFGGAAGRGWADEGTVDVMEQVFDSVLRQMPDHTRALYRFLGALPGTTFPAALPRAAGLPRVDAALGDLMTSHLVVAVGPGRDGAAPAGPPHRFRMHDLARAHAATEAATLPEEAARSLLRTVTDFYAEAVAHADRSIGGRFRLQDPPARSLTELGFAEGAFSGDGQGLDWLDAERGNILAVLRAAAREGLHDAVWRICESLWPLFHERARHADSLEAHPLGIEAARWENRPDAEIRMRNQLARAHAALGDLDRAAEELRAGEPLLALTEDARLRGILAETGGLVALAQGRTADARDRFTAALAANTERGDQHGIVVQSYQLADAVRASGDHAEARRLLAAALGLARETGDLAMIPKLTLLTARVHADAGEVAQAVAAATDAAEQAGEQGLTSKVREALELLLGLARRSGDTALAESCERRLAELRGPGDLPGGA
>NZ_CP016824.1|WP_067412112.1|2169744_2171499_+|hypothetical-protein
MEFRLPGISRARRPGRPLPGRDRWDTWEAPRARVLCVARTLTSATRLLDVLPLLRREDGIETYYTVNPGSAFAEGLHAYFTSLGVGDRLLSWEEATRRPFDLAVACTVNNSMRQLDAPLVVLPHGAGYNRLVTETTGDASAPAGLSRRELTWRGKVVPAAIGVSHSEQLGRLAGSCPEAVERAAVVGDICLDRIRRSLPLRDRYRALLGAVDGRRLVVLHSTWSSHSLLGTHPELPLELVTSLPADEYAVAAVLHPNVWARHSRRGVLERLERAMDAGLLVIPPEEGWRAAVVAGDWVVGDHGSTTLYSAALDRTVLLAATGLDELDAASPTAAFARRAPRLDVAGDLYAQLLRADAEHDPELLAPVVDSQWETPDKSTALTQDLLYGLLADAGVGPPAATPEPEPVPDPRPLAHRAPTAFDVTGRIGADGAVEVRRHPLAPRHDTEPRGFYAVTDEETHPLWPQSADVLARTLVDAATPPTVWAEEAFRRLPGLSVVGAALDTDRCLVRLRDGRVWEALADRPWGAARARLDPVLVACAVHVAASTDTGTAGGTELGAPLVIRTGRRLCRVSFRVAPGSCSGG
>NZ_CP016824.1|WP_067412113.1|2171616_2173374_+|FUSC-family-protein
MSEPTALRARAGTLRGVVPGWLGRSLRAARAPFPRAAAVRGALAVSVPLMAGLLTGHPVAGVVVGLGGLWAVGQDSAAPYKARALRIAALGGSAAAGLLAGATALRYGDAVVIAALLAVAGLVSGWVSVGGPLASVAGMHLLLGATVGTGIPVPGPWWAGPLELLGGALFALTLTCLPWLWRRHSPEREAVIAVFDAAERALSRAGTPGATEARARMTLALNTAQDLLAVHSSRKHAERPTSIGGLITAFRAAVQLVEAVTALMVEGRPLPPAVVRVPSLLAARVVPPVRAGRPAPEPAGHALAQDREPEPPFTADTPGLRALAEVYRAPGRSLTLLPDPPAYAGPRLADRLRFALLLGGCTLAAAVVAYLLHGPRGYWLPMTVAFLYKPDLGPVFGRALNRCLGTVAGVGMVAVVAWLVTDAWALTLVAAAFGAVMAAGVRYHYALSTFGLTVIVFVFIDFLGDDRQLLPSRVLETVIAAALVLTAHFLTRPDSWRVRAELRVAAADRAWRRYERRAPAASPDERHQLRRTAYRRLAEARQALDTAGAEPHRDPDRFPVLERRVARAEQGCDAITAYVVAGGRR
>NZ_CP016824.1|WP_067412115.1|2173389_2174127_-|hypothetical-protein
MTGKTTAYAERLSALLRERGMAPARAEELVAELTAYAAEAGSPLEEEFGPAGELADQLTRREGTDAVDGPGDGPDTWVWTADALQEVELLARFGGQGWEAERLDRLGRFVCRRDRQTPLRWSYRRETTGGRHREQLTARLATEGWELFGTWGPFAYFKRPEAAVTGPAAQLSAPPARPRRRVYFAPWILVTLAAAVAVAVATVLLAGSGAGLTDGASLAGALVGLTAGGLLGAWAWRTAARRHTG
>NZ_CP016824.1|WP_003948132.1|2174214_2174874_-|GntR-family-transcriptional-regulator
MAQATPTAERAYEHVKDLILDGTYGSGELLSEGQVAAELGISRTPVREAFLRLRSDGFLELYPKRGALVVPVSLGEGRDIMQARLLLESYALDTLAARGPEALRRVGDDLAARCGPAATPREARDAGHAYHAALVAAAGNRTVTGLFETLWHQHQRFTAAALIGRQEVAEDTAEHLALARALQHGDATGAKDLLHRHIGSILRRAGADGDSLSLPDRVA
>NZ_CP016824.1|WP_037844162.1|2174970_2175849_-|ABC-transporter-permease
MSTPGTLTDPARTDPTAPGYRPGRTLPLRVEAVRQLRRRRTQVMAAILALLPVVMVAAFAIGGEPERRGRVNLMDTATASGLNFAAVCLFVSAGFLLVIPVALFCGDTVASEAGWSSLRYLLAAPVPRARLLWSKLVVALAFSAAAMVLLPLVGLLVGTLAYGWGPLQIPTGGALPADEAVGRLAVVVAYVYVSQLVTAGLAFWLSTRTDAPLGAVGGAVGLTIVGNVLDAVTALGDWRAFLPAHWQFAWADALQTDIAWSGMLQGASVSVSYALILFALAFRGFAGKDIVS
>NZ_CP016824.1|WP_067412118.1|2175845_2178515_-|alpha/beta-fold-hydrolase
MRLNKHGPPRWRAALASAGVLAALLVPASSASAAEDSGGGVKRQDQILKTVDGVRIDTSYFTAGGEGRRPAVMLAHGFGSSKADLRQQAEKLAESGYAVLTWTARGFGRSTGKIGLNDPKAEVADARKLIDWLAERPEVQLDAEGDPRVGMTGASYGGAVSLLTAGYDERVDAIAPLITWWDLPEALFPNGVFKKLWTGMFLSTGGGCERFEDELCAMYNRVAVSGKPDAKAAELLAARSPKGVADRIKVPALFVQGQQDSLFPLSHTDQAAKALKKNGQPVAVDWMAGGHDGGNPEAARVEQRVTNWFDRYLKQDKNADPGPAFRVTRTGGVDSTNGAAELRGATGSRYPGLGHDPVRIPLTGREQKVDNPAGAVPPSISTLPGLGGGGPGGGESADQGSSLAQLSSLGIGVSFDFPGQHARFDSAPVEKDLRITGSPTVRVKVSADTKDAVLFGKVYDVGPGGRSQILPGQLVSPVRVTGADQGRTLTLNLPAIDHEVRKGHSLRVVLAATDLGYASPAEPATYRIAAEGALNVPTAPAVRTAATPLPTWVWALPLGAAVVAAGLLLLGRRRTSAPPADPELADVPLRITGLSKKYAGSTDRYAVRDLSFGVERGQVLGLLGPNGAGKTTTLRMLMGLIRPDEGEIRVFGQAIRPGAPVLSRVGAFVEGAGFLPHLSGRANLDLYWQATGRPAEDAHIEQALEIAGLGGALERAVRTYSQGMRQRLAIAQAMLGLPDLLILDEPTNGLDPPQIREMREVMIRYAAAGRTVIVSSHLLAEVEQTCTHLVVMDQGQLVQAGPVAEIVGSGDTLHVGLAAPVDAPLADKVAALDGIAAVDPTENGLLVRLDGIGADQLVVELVRLGVPVASVMPHRRLEDAFLTLIGGTG
>NZ_CP016824.1|WP_067412121.1|2178921_2179524_-|nucleotidyltransferase-family-protein
MISRLPLDEQLPALRTTLSHNPTLLTVLDRAATLALPGWYLTAGCLFQTIWNVTTGRPPEQGIKDYDLFSYDPADLSYEAEDHAIRTGRTLFAGLPAEVEIRNQARVHLWYEAKFGTPCPPHPSTEAAIDTFAATTCCLGIRLDPHDHWHVYAPHGLADIFNLVLRPNPVLAPREVYETKAERWQRQWPELRVLGWPETD
>NZ_CP016824.1|WP_030770989.1|2179594_2181094_-|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase
MKTVHHWIGGQAVDGASGSFGPVTDPATGEVTTQVALASADEVDAAVATARAAYASWGTSSLAQRTTVLFKFRALLDQHREEIARLITAEHGKVHDDALGEVARGLEIVDLACGITVQLKGELSTQVASRVDVASIRQPLGVVAGITPFNFPAMVPMWMFPLAVACGNTFVLKPSEKDPSAALRLAELFSEAGLPDGVLNVVNGDKVAVDRLLEHPDVAAISFVGSTPIARHIHATASAHGKRVQALGGAKNHMLVLPDADLDAAADAAVSAAYGSAGERCMAVSAVVAVGAIGDELVAKIKERAEKITIGPGHDPASEMGPLITAAHRDKVAGYVAGAAAQGADVVLDGTGFTVEGYEKGHWIGLSLLDKVSTDSDAYRDEIFGPVLCVLRAETYEEGLALINASPYGNGTAVFTRDGGAARRFQLEVEAGMVGVNVPIPVPVGYHSFGGWKDSLFGDHHIYGNDGTHFYTRGKVVTTRWPDPADAPTGVDLGFPRNH
>NZ_CP016824.1|WP_067412125.1|2181108_2182995_-|3D-(3,5/4)-trihydroxycyclohexane-1,2-dione-acylhydrolase-(decyclizing)
MRLTTAQALIRFLSVQYSERDGERQRLIPAVWGVFGHGNVAGLGQALAEHTAERPDGTGDLRFHQGRSEQAMVHAATGFARQSRRLAAHAVTTSIGPGATNLVTGAALATVNRLPVLLLPGDTFATRPADPVLQQLELPYAGDITVNDCLRPVSRHFDRVTRPEALIPAALTAMRVLTDPAATGAVTLALPQDVQAEAYDWPEEFFAERTWHIRRPAPDTASLTEAAALLRAARRPLVVAGGGVKYAGAEAALDAFARATGIPVAATQAGKGALPHDHPQDVGALGHTGTATADDLARTADLVLAVGTRLTDFTTASGTLFAADGVRFAHLNLDPADAHKLAAHAVVGDAREGLTALTGLVGGHRLPDAHVTAYTAAKADWEARVDAAYAAPDPTARPTQTQLLGALDALVTGEDILVNAAGSLPGDLHRLWRARSADQYHVEYGYSCMGYEIPGALGILLADPHRPVWALVGDGTYLMNPTELVTAVQESLPLKLVLVDNHGYASIGGLSRAVGAEGFGTAYRMPGPGGLLDGEPLPLDLAANAASLGVRMLRAETVAELREALAEVRTATVPTGVYVRTETPDTVSSPTPAQAWWDVPVARTAHREEAARARQEYDRNVAARRRHL

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Crispr_ID: NZ_CP016824_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_8

2545807-2545955

Orphan

Consensus_repeat	Method
GGGTGGTCCGCGCGCACGCGGGGGTGG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP016824_8

>merge|NZ_CP016824|8|2545807-2545955|CRISPRCasFinder
GGGTGGTCCGCGCGCACGCGGGGGTGGTCCGGTCAGGAGACGGGCTGGTTGGCCCTGAGCCGGGTGGTCCCCGCGCACGCGGGGGTGGCCCCGAGGCCGCTCCGGTCGTCACGAACATCATCGAGTGGTCCCCCCGCAGGCGGGCAAGC

>NZ_CP016824|8|8|2545807-2545955|CRISPRCasFinder
GGGTGGTCCGCGCGCACGCGGGGGTGG	TCCGGTCAGGAGACGGGCTGGTTGGCCCTGAGCC
GGGTGGTCCCCGCGCACGCGGGGGTGG	CCCCGAGGCCGCTCCGGTCGTCACGAACATCATC
GAGTGGTCCCCCCGCAGGCGGGCAAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067412582.1\|2547265_2548144_+\|M55-family-metallopeptidase	unknown	unknown	gnl\|CDD\|176450
NZ_CP016824.1\|WP_067412590.1\|2555104_2556625_+\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379232
NZ_CP016824.1\|WP_003948467.1\|2538189_2538687_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_010638599.1\|2550710_2551961_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270450
NZ_CP016824.1\|WP_008410772.1\|2553814_2555008_+\|family-1-glycosylhydrolase	unknown	unknown	gnl\|CDD\|274539
NZ_CP016824.1\|WP_067412593.1\|2556685_2557150_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NZ_CP016824.1\|WP_067412587.1\|2549180_2550080_-\|acetylxylan-esterase	unknown	unknown	gnl\|CDD\|225989
NZ_CP016824.1\|WP_067412563.1\|2536925_2537753_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379142
NZ_CP016824.1\|WP_003948481.1\|2552913_2553747_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP016824.1\|WP_067412566.1\|2539044_2540298_+\|ornithine--oxo-acid-transaminase	unknown	unknown	gnl\|CDD\|179736
NZ_CP016824.1\|WP_067412579.1\|2546118_2547228_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP016824.1\|WP_008410790.1\|2545331_2545544_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412570.1\|2540310_2540844_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP016824.1\|WP_067412577.1\|2544648_2545188_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP016824.1\|WP_067412574.1\|2543114_2544542_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP016824.1\|WP_067412584.1\|2548191_2549046_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP016824.1\|WP_003948480.1\|2551966_2552917_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP016824.1\|WP_067412573.1\|2540887_2542108_-\|glutathionylspermidine-synthase-family-protein	unknown	unknown	gnl\|CDD\|367631
NZ_CP016824.1\|WP_018894285.1\|2542251_2542830_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240430
NZ_CP016824.1\|WP_030304832.1\|2535996_2536833_+\|DUF1206-domain-containing-protein	unknown	unknown	gnl\|CDD\|377695

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067412582.1\|2547265_2548144_+\|M55-family-metallopeptidase	gnl\|CDD\|176450	cd08663, DAP_dppA_1, Peptidase M55, D-aminopeptidase dipeptide-binding protein family. M55 Peptidase, D-Aminopeptidase dipeptide-binding protein (dppA; DAP dppA; EC 3.4.11.-) domain: Peptide transport systems are found in many bacterial species and generally function to accumulate intact peptides in the cell, where they are hydrolyzed. The dipeptide-binding protein (dppA) of Bacillus subtilis belongs to the dipeptide ABC transport (dpp) operon expressed early during sporulation. It is a binuclear zinc-dependent, D-specific aminopeptidase. The biologically active enzyme is a homodecamer with active sites buried in its channel. These self-compartmentalizing proteases are characterized by a SXDXEG motif. D-Ala-D-Ala and D-Ala-Gly-Gly are the preferred substrates. Bacillus subtilis dppA is thought to function as an adaptation to nutrient deficiency; hydrolysis of its substrate releases D-Ala which can be used subsequently as metabolic fuel. This family also contains a number of uncharacterized putative peptidases.	7.35674e-125
NZ_CP016824.1\|WP_067412590.1\|2555104_2556625_+\|VCBS-repeat-containing-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	3.02363e-05
NZ_CP016824.1\|WP_003948481.1\|2552913_2553747_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.0156e-89
NZ_CP016824.1\|WP_010638599.1\|2550710_2551961_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.70213e-130
NZ_CP016824.1\|WP_008410772.1\|2553814_2555008_+\|family-1-glycosylhydrolase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	5.76e-83
NZ_CP016824.1\|WP_067412593.1\|2556685_2557150_-\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	1.39944e-14
NZ_CP016824.1\|WP_067412587.1\|2549180_2550080_-\|acetylxylan-esterase	gnl\|CDD\|225989	COG3458, COG3458, Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism].	2.59835e-55
NZ_CP016824.1\|WP_067412563.1\|2536925_2537753_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	5.68905e-07
NZ_CP016824.1\|WP_067412566.1\|2539044_2540298_+\|ornithine--oxo-acid-transaminase	gnl\|CDD\|179736	PRK04073, rocD, ornithine--oxo-acid transaminase; Provisional.	0
NZ_CP016824.1\|WP_067412579.1\|2546118_2547228_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.24728e-88
NZ_CP016824.1\|WP_067412570.1\|2540310_2540844_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	7.48041e-13
NZ_CP016824.1\|WP_067412577.1\|2544648_2545188_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	9.62867e-28
NZ_CP016824.1\|WP_067412574.1\|2543114_2544542_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	7.22705e-106
NZ_CP016824.1\|WP_067412584.1\|2548191_2549046_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.77466e-15
NZ_CP016824.1\|WP_003948480.1\|2551966_2552917_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.31685e-90
NZ_CP016824.1\|WP_067412573.1\|2540887_2542108_-\|glutathionylspermidine-synthase-family-protein	gnl\|CDD\|367631	pfam03738, GSP_synth, Glutathionylspermidine synthase preATP-grasp. This region contains the Glutathionylspermidine synthase enzymatic activity EC:6.3.1.8. This is the C-terminal region in bi-enzymes. Glutathionylspermidine (GSP) synthetases of Trypanosomatidae and Escherichia coli couple hydrolysis of ATP (to ADP and Pi) with formation of an amide bond between spermidine and the glycine carboxylate of glutathione (gamma-Glu-Cys-Gly). In the pathogenic trypanosomatids, this reaction is the penultimate step in the biosynthesis of the antioxidant metabolite, trypanothione (N1,N8-bis-(glutathionyl)spermidine), and is a target for drug design. This region, the pre-ATP grasp region, probably carries the substrate-binding site.	2.93474e-172
NZ_CP016824.1\|WP_018894285.1\|2542251_2542830_-\|hypothetical-protein	gnl\|CDD\|240430	PTZ00473, PTZ00473, Plasmodium Vir superfamily; Provisional.	0.00480075
NZ_CP016824.1\|WP_030304832.1\|2535996_2536833_+\|DUF1206-domain-containing-protein	gnl\|CDD\|377695	pfam06724, DUF1206, Domain of Unknown Function (DUF1206). This region consists of two a pair of transmembrane helices and occurs three times in each of the family member proteins.	7.68956e-13

>NZ_CP016824.1|WP_008410790.1|2545331_2545544_-|hypothetical-protein
MLTTTRPRTTPVPPPCPDRACHTDIHGRLWKDTTYLRNDPDNWRWYCSRCGQHWMPTHEQFAWYRTLPVA
>NZ_CP016824.1|WP_067412577.1|2544648_2545188_+|carboxymuconolactone-decarboxylase-family-protein
MTTENTPTAPSTSTTPDEKAAAYLPEHTPRISVAELAPDLYRALARADAAARKNLDPVIGELVKIRASQINHCAFCLDMHTKDALAMGESVERIVQLSAWEESKHYYTAKEIAAIELTEAITVLTDGFVPDEVYAQAAAHFDENELAHLIGAITVINAWNRLSVAARNVPGHYVPGSLG
>NZ_CP016824.1|WP_067412574.1|2543114_2544542_-|PLP-dependent-aminotransferase-family-protein
MTESWANLGIDLHLEPAGPGLRKGLTDALREAVRSGRLAPGTRLPSSRTLAGDLGIARNTVADAYADLVAEGHLTARQGSGTRVAEQAGPASSVPRRQRPVRVPERAGPAHDLTPGTPDLSAFPRAAWLKAARRALTAAPNDAFGYGDPRGRPELRAALTEYLARVRGVAADPERIVVCAGVAHGLKLVTEVLAARGGHGGRQGSGTVAVETYGLRFHREWLAEEGVGTVPLPFDADGTDPAGLDGERAVLLTPTHQFPMGGTLSPARRAAVVDWARRTGGLILEDDYDGEFRHDRRPVGALQGLAPDRVAYFGTASKALAPGLRLGWLVLPPGLVDEVLAAKGYADTCGAPDQLTLAEFLTSGAYDRQVRLMRLRYRRRRDELVATLARRAPSVRVGGIAAGLHAVLLLPPGTESEVLRAAAWHGLGVQGLSWFRHPDAEAAGRPVPEGLVIGYGRPPDHAWQSALETLCRCLP
>NZ_CP016824.1|WP_018894285.1|2542251_2542830_-|hypothetical-protein
MAENITVPAVRALDAPVARPATGPGRGAAPQGVPVADERPPAPVRLTKSGAGEPGSGSGEPSAEQRRKKAARRRVRSSTVALGSMGVLAAALAACGSEPDRRCVDRNSYSYGGGYKVVDSSQCRNGSSGSTGGTGGGGSSGGSGRYGSDRSSNAGWYYGGDSKSGYASDGSFNKSSVSSGGFGCSGKGSGGG
>NZ_CP016824.1|WP_067412573.1|2540887_2542108_-|glutathionylspermidine-synthase-family-protein
MQRHTIEPRPGWQETVEAQGVIYPLTRHPDDSLRPYWDESAYYSFSLAEVEALEEVVEELHAMCLAAAAHIVEKDRFAELGITDPRLASLVTEAWHRKAELPSLYGRFDLWYDGSGAPAKMLEYNADTPTSLVEAASAQWFWMEERFPGADQWNSLHERLVDAWRAQAALLPPGSPVHFAHTIDDECGEDLMTVAYLRETAAQAGLETEAIAVEDIGWDSLSHRFVDQRLRFIRSCFKLYPWEWLATDDFGPHVLDTLDNGGGTGSTLWIEPAWKMLLSNKALLAILWELYPGHPNLLASYLDGPRELATTTGYVTKPLLGREGAGVTLHQPGGTQTPASATGPSCYQQLALLPDLSTPAPGAHSPTNHVVLGAWVVADEAAGLGIRESAGPVTDGYARFLPHVIL
>NZ_CP016824.1|WP_067412570.1|2540310_2540844_-|GNAT-family-N-acetyltransferase
MPELQRLRADHAPALLAFERENRAWFARTISDRGDAYFADFPARHRALLTYQDEGTDHFHVLVADDATTILGRFNLMDITDGQAELGFRMAESATGRGLATEAARTVCHLAATAYALTSLRAQANLDNLASHTVLTRTGFTATEQTVLRNGTAGRRYVKELAGPEEGAARAIGAAGL
>NZ_CP016824.1|WP_067412566.1|2539044_2540298_+|ornithine--oxo-acid-transaminase
MSGTPSGTHSSPAPGSATAEAIDAAEAHSAHNYHPLPVVVASAEGAWMTDVDGKRYLDLLAGYSALNFGHANPRLIAAAKAQLDRVTLTSRAFFHDRFAAFCEELAALCGKDMVLPMNTGAEAVETAVKTARKWGYRVKGVPDGAARIVVASGNFHGRTTTIVSFSTDEEARADYGPYTPGFVVVPYGDADALEAALTDDTVAVLLEPIQGEAGVLVPPAGYLRRVRELTAERNVLFIADEIQSGLGRTGRTFACEHEGVVPDLYLLGKALGGGVVPVSAVVGDSDVLGVFRPGEHGSTFGGNPLACAVALEVIAMLRTGEYQARATELGTRLHNALADLVKADGPVRAVRGRGLWAGVDLDPAVGTGREISERLMSRGVLVKDTHGSTIRIAPPLVISAEDLDWGLGELRGVLGMA
>NZ_CP016824.1|WP_003948467.1|2538189_2538687_-|hypothetical-protein
MSALDFCAEVLIEGRIRGAGLGDSMAVWDRCMGYEYTDGLSRGRLRRDYGLVEIIFEQYDTGWHATGIEIQAYRLGRFGVGIVPQVLAPYFGAVESRVNAKELLETVAAKGFGIEAVHEEGARTHAYRVDSSGGVVYVLMAETRSMKVPSVGDVWTVVLELPDEE
>NZ_CP016824.1|WP_067412563.1|2536925_2537753_-|trypsin-like-peptidase-domain-containing-protein
MKKPLAGALLAAALLGASAAPAVAAPGPAAPAAVDLAGTVALSNCSGSVVRAPSASADDPALVLSNGHCLETGFPAPGEVLVDQPSSRSFTLLDGAGDGVGTLRAAKLAYGTMTDTDVSLYQLGESYAEIESAYGIEALELDAARPSEGAAITVASGYWKRTYNCSVDGFAHQLKEGSWTWKDSVRYTDACDTIGGTSGSPVIDDATGKVVAVNNTGNESGGRCTDNNPCEVDENGEVTVREGINYGQQTYTLVPCIGPGSEIDLGREGCAVPKP
>NZ_CP016824.1|WP_030304832.1|2535996_2536833_+|DUF1206-domain-containing-protein
MNSSSMAREGHRQARRAADSKVVSAGARAGFAARGVIYLLVGLLAGQIAFQGDGKQADRGGALQEISGQPFGGILLWVIGIALVGMALWRLSEAAFGAAGPDGDKAMKRVVSGARAVFYAFVAYSVLSFAAGEKSGGGSSDKQSQDITAQALGLPGGQWIVGVAALGVAVAGVVVGARAVMRKYHKHLRMGAMSRRARQFVDVTGVFGGAARGLVFAAAGVFAVVAAVDYDPDEAKGMDDTLRSFADTPAGPWLLVLVAVGLAAFGLFSFANAKWRKV
>NZ_CP016824.1|WP_067412579.1|2546118_2547228_+|LacI-family-transcriptional-regulator
MGDGAAGTPTVYDVAGRAGVSIATVSRVYRSPESVREATREKVLVAARELGYVPSGSARGLASRSTGVLGLCFPDYSDPDAESEAAAVDADDDHAFMLYSDQIIRGMERAARRHGYALLIAASLTGGPESLVAKVAGRVDGCAVLARTVPTEDLEVISRRLPVVMLAGPPEQDGPGGLDRLDHIEVANADGQRELTRHLIEDHGLRRLTFVGGIEDSPDAEARFAGFRDACRAAGLPVPDEPDLRAELMTQAGGARAAEELVDRAGPDGLPEGVLFANDQMAVGALHALGRRGLRVPEDLAVTGFDGIPLGRLVQPTLTTVRQPMRRLGEEAVELLVRRLAEEKRGEPESLVLPVEVVRRASCGCGHEA
>NZ_CP016824.1|WP_067412582.1|2547265_2548144_+|M55-family-metallopeptidase
MDNHGSTGEDPTSEAKGPRILISVDMEGVSGIVHPRETHPDGYDYGRARALMTAEANAAVAGVLDAEPGAEVWVADAHGSYRNLLPEEIDRRARLVRGKPRPLGMLGGIDERTDAVLFVGYHVRAGAGPGVLAHTMSDALLDVRVDGRSLGEIGLNAAMAGHLGVPVVLLSGDDAACAEVRELVPGVRTVAVKEALGQFAAAGLHPEEARERLRRTAAEAVAGREEVRPFALSGPQTVEVDLAAAHTVDLAMLIPGVTRAGGARTVTFTAPDFREAYRVVLLLVQLGSIRPA
>NZ_CP016824.1|WP_067412584.1|2548191_2549046_-|alpha/beta-hydrolase
MSGAFSRGSRSPGESRLPVHATVWDDRPNSGGSGSRWPVVLVHGILTWGTDPRYGFAAQRPLAARRRLLLMDRRGYGRSPDIARSDWAVDAEDIVELLGTGAHLVGHAYGGVGALAAAVRRPDLVRSLTLIQPGALRPAERHPVVAEALARARAATAALPPDLTPADFLRGATESVGMETPEATPERLRAAATTMAELPCWDAEIDLSPLARAAFPQLLVSGDWEGAPEPYRTYAGLPLIACAEEIAAATGAAHLVVPGHYPHTQQPERVNAALEHLWEAADQG
>NZ_CP016824.1|WP_067412587.1|2549180_2550080_-|acetylxylan-esterase
MPGGFAGFWRGRYEEALEVVTAPEVGAVEEVRDGVRVRRVSFSSVGGVRLGGWLALPVEGPAEHGFVVGHGYGGRDAPGPDLPSPLPRSAALLPCVRGMGERSRLPGGPSVADAHVLHGISSRDTYVIGACVADLWCAASALLELVPELARHPSGPRLGYLGESFGGGLGALALPWDDRFAAARLTVPTFGNHPLRLTLPCTGSGESVRRHHRDHPHVVDVLSYFDAATAATFVRVPTLVAAALFDPAVPPPGQFAVHNALPDDLRALHVLSAGHFDHPGAEEEAAGLARADREFFTRL
>NZ_CP016824.1|WP_010638599.1|2550710_2551961_+|sugar-ABC-transporter-substrate-binding-protein
MHRVARTATAVIAASTALAVVTACGGSSGTEVAADAEQTLTVWAMGAEGEKLAEVAKEYEKENPHLKVKVTPVGWDVAHQKLVSAAAAGNLPDIAQMGGSYLGEFAELGVLEPVDTKRFQEKDFFPAGWQQGEVDGEVYGVPWYVDTRVLYYRTDLAEKAGVDKAPADWKELRALASAYQKDAGTKWGLSIQPSGLDTVQSFYPFLYSAGGEIIDEDGKVVVDSPAAVKALKEYGAYFDKGLANKSVPPGYDVVKDFGNGRVPMFFGGPWHVTLLNEGQPDIKGKWAVAEVPADEASVSMAGGSSLTVSKDSPHKAAAEEFIAHLTSTEGQADWYERTKDLPANTTAWESGSLADDPALKVFEKQMKTAKASPTLANLSEITDKVDQAIAQVTQGKATAEEALGKAKDQIEGLVQK
>NZ_CP016824.1|WP_003948480.1|2551966_2552917_+|sugar-ABC-transporter-permease
MSTTTRKADEAAPGGRRPGRRRGSLGVQNAAGWLFSTPFLVLFAVFMAFPIVATLLMSFTDFGLGNVTRPLDARFIGFENYTRLFGDERFLKSLFNTAYFVVVGVPLTIGLGLLVAVLLNNGIDRARTFFRVGFYAPVVTSIVAVAVVWRFVLDPSDGLIAGLASEVGLTAPDFLGSEALAMPSLIAMAVWRNLGTVMVLFIAGLQAIPTEVREAARLDGVGPWQELRRITIPLLRPTLLYASVITTIGYLNVFEEPFVMTQGGPSDSTLTVSLNMYREGFNFFHMGYASAMAYVLFVVIMGITVLQLRLLKDNTR
>NZ_CP016824.1|WP_003948481.1|2552913_2553747_+|carbohydrate-ABC-transporter-permease
MSAEGRVRRPLTYVLLSGGLLVMAAPFLWMGLSAFKTQRELSASPPVWIPSQWTLANFRQLLADLDLPLYFMNSVIVAVLVTVSNLVFCSMLGYALAKLNFAGRNKVFGVVLGALMVPGNLMLLPLFVLMSKLQLIDSYAGLVLPFAAGAFGVFLMRQFMQSIPDELLEAARMDGAGEWFIFWRIVMPLVKPALATLAILTFLGSWNNFVWPLIATNDPDKYTLPVALATFATDPNKAGGSNGVLMAGSFLIVLPVLAVFIALQRHFTQGIATAGMK
>NZ_CP016824.1|WP_008410772.1|2553814_2555008_+|family-1-glycosylhydrolase
MTSTPFPEGFLWGASTAAHQIEGNNTDSDWWVKEHTAGTHIQEPSYDACDSYHRWPEDMDLLASLGFTDYRFSIEWARIEPVEGHFSRAELAHYRRMVEGAIERGLRPMVTLHHFTVPQWFEARGGWTAEGATELFARYVAACAPVIATGVAHVCTINEPNMIAVMAGQAKRGDIGFPPAGLPTPDEETTHAVIAAHHAAVKEVRAISSGIKVGWTIANQVYQALPGAEEVTAAYRHPREDVFIEAARGDDWIGVQSYTRTRIGADGPIPASPEAERTLTEWEYYPTAVGHALRHTAEVVGDVPLIVTENGIATADDERRTAYYTGALGEVAAAIEDGLKVEGYLAWSALDNYEWGSFRPTFGLIAVDWETFERTARPSAVWLGSLGRTRELPGRAV
>NZ_CP016824.1|WP_067412590.1|2555104_2556625_+|VCBS-repeat-containing-protein
MAWMRRPDTPTTRRGRSGRAAASLAAALLVSGGLSAAALAPTTALAADGPAAASADDFNGDGYADLVSGAPGGTVSGKAGAGYVAVTYGSAKGLAPAPGTVVSRSTAGVPGAATAKQRFGETFAKGDLDGDGYSDLVIGSATAEPGAVILWGSPKGLTGGTAVAGFGQAPQVGDFDGDGQADLALFGAAQVAGDDPVTQEARLLKGPLTRQGTPDEQLDFLDRSEWWGYDSDGPACAEDDSCVDGPTSVGGPVRPKAVGDVNGDGSDDLVTWLYEGDGVWAHHLFTGSATGFRDAQEAGPIGSSGDDAAVGVGDVDGDGYDDVVTGSGEATAKVTVRYGSAAGLEGREQAFDQSLPGLHGAQKKGDHFGSCVAVADVTGDGRAEIALGISGEDFSGLTDAGSIALLHGTASGVTGEGSQVLHQNTAGVPGVAESGDKFGSACALLDTDGDGHRDLVAAAAEENEQAGAVWALRGTGEGLTVEGASAFGPGHVGGPVTKAKFGSFLR
>NZ_CP016824.1|WP_067412593.1|2556685_2557150_-|VOC-family-protein
MAEKSFPAPESGMLLSYFLTVADVPRSRAFYSEVLGGEVILEENPCTVRLANSWLIMNPGGGPTPDKPGITLHPPEDPATATCFLNIRVADIQAVYEEWSAKGAEFVTPPIDRKAEIRCYLRDPDGYLIEIGQATGMLHGVYADPPAGKGPVTR

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Crispr_ID: NZ_CP016824_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_9

2550302-2550388

Orphan

Consensus_repeat	Method
CAGCCCGGCCGGCGCTTGAGGCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_9

>merge|NZ_CP016824|9|2550302-2550388|CRISPRCasFinder
CAGCCCGGCCGGCGCTTGAGGCCATCCTGAAGGCGCACGCACACGGCAACCTGAGCCCAATCTCAGCCCGGCCGGCGCTTGAGGCCA

>NZ_CP016824|9|9|2550302-2550388|CRISPRCasFinder
CAGCCCGGCCGGCGCTTGAGGCCA	TCCTGAAGGCGCACGCACACGGCAACCTGAGCCCAATCT
CAGCCCGGCCGGCGCTTGAGGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067412582.1\|2547265_2548144_+\|M55-family-metallopeptidase	unknown	unknown	gnl\|CDD\|176450
NZ_CP016824.1\|WP_067412590.1\|2555104_2556625_+\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379232
NZ_CP016824.1\|WP_003948481.1\|2552913_2553747_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP016824.1\|WP_008410772.1\|2553814_2555008_+\|family-1-glycosylhydrolase	unknown	unknown	gnl\|CDD\|274539
NZ_CP016824.1\|WP_067412593.1\|2556685_2557150_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NZ_CP016824.1\|WP_067412587.1\|2549180_2550080_-\|acetylxylan-esterase	unknown	unknown	gnl\|CDD\|225989
NZ_CP016824.1\|WP_067412579.1\|2546118_2547228_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP016824.1\|WP_003948487.1\|2560319_2561441_-\|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213261
NZ_CP016824.1\|WP_067412574.1\|2543114_2544542_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP016824.1\|WP_067412598.1\|2561437_2562955_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|235000
NZ_CP016824.1\|WP_008410790.1\|2545331_2545544_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412570.1\|2540310_2540844_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP016824.1\|WP_067412577.1\|2544648_2545188_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP016824.1\|WP_010638599.1\|2550710_2551961_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270450
NZ_CP016824.1\|WP_067412584.1\|2548191_2549046_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP016824.1\|WP_003948485.1\|2557346_2558324_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270361
NZ_CP016824.1\|WP_067412573.1\|2540887_2542108_-\|glutathionylspermidine-synthase-family-protein	unknown	unknown	gnl\|CDD\|367631
NZ_CP016824.1\|WP_067412595.1\|2558325_2560320_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226644
NZ_CP016824.1\|WP_018894285.1\|2542251_2542830_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240430
NZ_CP016824.1\|WP_003948480.1\|2551966_2552917_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067412582.1\|2547265_2548144_+\|M55-family-metallopeptidase	gnl\|CDD\|176450	cd08663, DAP_dppA_1, Peptidase M55, D-aminopeptidase dipeptide-binding protein family. M55 Peptidase, D-Aminopeptidase dipeptide-binding protein (dppA; DAP dppA; EC 3.4.11.-) domain: Peptide transport systems are found in many bacterial species and generally function to accumulate intact peptides in the cell, where they are hydrolyzed. The dipeptide-binding protein (dppA) of Bacillus subtilis belongs to the dipeptide ABC transport (dpp) operon expressed early during sporulation. It is a binuclear zinc-dependent, D-specific aminopeptidase. The biologically active enzyme is a homodecamer with active sites buried in its channel. These self-compartmentalizing proteases are characterized by a SXDXEG motif. D-Ala-D-Ala and D-Ala-Gly-Gly are the preferred substrates. Bacillus subtilis dppA is thought to function as an adaptation to nutrient deficiency; hydrolysis of its substrate releases D-Ala which can be used subsequently as metabolic fuel. This family also contains a number of uncharacterized putative peptidases.	7.35674e-125
NZ_CP016824.1\|WP_067412590.1\|2555104_2556625_+\|VCBS-repeat-containing-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	3.02363e-05
NZ_CP016824.1\|WP_003948481.1\|2552913_2553747_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.0156e-89
NZ_CP016824.1\|WP_008410772.1\|2553814_2555008_+\|family-1-glycosylhydrolase	gnl\|CDD\|274539	TIGR03356, BGL, beta-galactosidase.	5.76e-83
NZ_CP016824.1\|WP_067412593.1\|2556685_2557150_-\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	1.39944e-14
NZ_CP016824.1\|WP_067412587.1\|2549180_2550080_-\|acetylxylan-esterase	gnl\|CDD\|225989	COG3458, COG3458, Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism].	2.59835e-55
NZ_CP016824.1\|WP_067412579.1\|2546118_2547228_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.24728e-88
NZ_CP016824.1\|WP_003948487.1\|2560319_2561441_-\|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213261	cd03294, ABC_Pro_Gly_Betaine, ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system. This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporters is the obligatory coupling of ATP hydrolysis to substrate translocation. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.54089e-163
NZ_CP016824.1\|WP_067412574.1\|2543114_2544542_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	7.22705e-106
NZ_CP016824.1\|WP_067412598.1\|2561437_2562955_-\|oxidoreductase	gnl\|CDD\|235000	PRK02106, PRK02106, choline dehydrogenase; Validated.	3.45277e-119
NZ_CP016824.1\|WP_067412570.1\|2540310_2540844_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	7.48041e-13
NZ_CP016824.1\|WP_067412577.1\|2544648_2545188_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	9.62867e-28
NZ_CP016824.1\|WP_010638599.1\|2550710_2551961_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.70213e-130
NZ_CP016824.1\|WP_067412584.1\|2548191_2549046_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.77466e-15
NZ_CP016824.1\|WP_003948485.1\|2557346_2558324_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270361	cd13643, PBP2_BCP_2, Substrate-binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline transport system-like; the type 2 periplasmic-binding protein fold. This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to certain quaternary ammonium compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as glycine betaine, proline betaine, choline, and carnitine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	8.22509e-110
NZ_CP016824.1\|WP_067412573.1\|2540887_2542108_-\|glutathionylspermidine-synthase-family-protein	gnl\|CDD\|367631	pfam03738, GSP_synth, Glutathionylspermidine synthase preATP-grasp. This region contains the Glutathionylspermidine synthase enzymatic activity EC:6.3.1.8. This is the C-terminal region in bi-enzymes. Glutathionylspermidine (GSP) synthetases of Trypanosomatidae and Escherichia coli couple hydrolysis of ATP (to ADP and Pi) with formation of an amide bond between spermidine and the glycine carboxylate of glutathione (gamma-Glu-Cys-Gly). In the pathogenic trypanosomatids, this reaction is the penultimate step in the biosynthesis of the antioxidant metabolite, trypanothione (N1,N8-bis-(glutathionyl)spermidine), and is a target for drug design. This region, the pre-ATP grasp region, probably carries the substrate-binding site.	2.93474e-172
NZ_CP016824.1\|WP_067412595.1\|2558325_2560320_-\|ABC-transporter-permease-subunit	gnl\|CDD\|226644	COG4176, ProW, ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism].	1.57704e-76
NZ_CP016824.1\|WP_018894285.1\|2542251_2542830_-\|hypothetical-protein	gnl\|CDD\|240430	PTZ00473, PTZ00473, Plasmodium Vir superfamily; Provisional.	0.00480075
NZ_CP016824.1\|WP_003948480.1\|2551966_2552917_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.31685e-90

>NZ_CP016824.1|WP_067412587.1|2549180_2550080_-|acetylxylan-esterase
MPGGFAGFWRGRYEEALEVVTAPEVGAVEEVRDGVRVRRVSFSSVGGVRLGGWLALPVEGPAEHGFVVGHGYGGRDAPGPDLPSPLPRSAALLPCVRGMGERSRLPGGPSVADAHVLHGISSRDTYVIGACVADLWCAASALLELVPELARHPSGPRLGYLGESFGGGLGALALPWDDRFAAARLTVPTFGNHPLRLTLPCTGSGESVRRHHRDHPHVVDVLSYFDAATAATFVRVPTLVAAALFDPAVPPPGQFAVHNALPDDLRALHVLSAGHFDHPGAEEEAAGLARADREFFTRL
>NZ_CP016824.1|WP_067412584.1|2548191_2549046_-|alpha/beta-hydrolase
MSGAFSRGSRSPGESRLPVHATVWDDRPNSGGSGSRWPVVLVHGILTWGTDPRYGFAAQRPLAARRRLLLMDRRGYGRSPDIARSDWAVDAEDIVELLGTGAHLVGHAYGGVGALAAAVRRPDLVRSLTLIQPGALRPAERHPVVAEALARARAATAALPPDLTPADFLRGATESVGMETPEATPERLRAAATTMAELPCWDAEIDLSPLARAAFPQLLVSGDWEGAPEPYRTYAGLPLIACAEEIAAATGAAHLVVPGHYPHTQQPERVNAALEHLWEAADQG
>NZ_CP016824.1|WP_067412582.1|2547265_2548144_+|M55-family-metallopeptidase
MDNHGSTGEDPTSEAKGPRILISVDMEGVSGIVHPRETHPDGYDYGRARALMTAEANAAVAGVLDAEPGAEVWVADAHGSYRNLLPEEIDRRARLVRGKPRPLGMLGGIDERTDAVLFVGYHVRAGAGPGVLAHTMSDALLDVRVDGRSLGEIGLNAAMAGHLGVPVVLLSGDDAACAEVRELVPGVRTVAVKEALGQFAAAGLHPEEARERLRRTAAEAVAGREEVRPFALSGPQTVEVDLAAAHTVDLAMLIPGVTRAGGARTVTFTAPDFREAYRVVLLLVQLGSIRPA
>NZ_CP016824.1|WP_067412579.1|2546118_2547228_+|LacI-family-transcriptional-regulator
MGDGAAGTPTVYDVAGRAGVSIATVSRVYRSPESVREATREKVLVAARELGYVPSGSARGLASRSTGVLGLCFPDYSDPDAESEAAAVDADDDHAFMLYSDQIIRGMERAARRHGYALLIAASLTGGPESLVAKVAGRVDGCAVLARTVPTEDLEVISRRLPVVMLAGPPEQDGPGGLDRLDHIEVANADGQRELTRHLIEDHGLRRLTFVGGIEDSPDAEARFAGFRDACRAAGLPVPDEPDLRAELMTQAGGARAAEELVDRAGPDGLPEGVLFANDQMAVGALHALGRRGLRVPEDLAVTGFDGIPLGRLVQPTLTTVRQPMRRLGEEAVELLVRRLAEEKRGEPESLVLPVEVVRRASCGCGHEA
>NZ_CP016824.1|WP_008410790.1|2545331_2545544_-|hypothetical-protein
MLTTTRPRTTPVPPPCPDRACHTDIHGRLWKDTTYLRNDPDNWRWYCSRCGQHWMPTHEQFAWYRTLPVA
>NZ_CP016824.1|WP_067412577.1|2544648_2545188_+|carboxymuconolactone-decarboxylase-family-protein
MTTENTPTAPSTSTTPDEKAAAYLPEHTPRISVAELAPDLYRALARADAAARKNLDPVIGELVKIRASQINHCAFCLDMHTKDALAMGESVERIVQLSAWEESKHYYTAKEIAAIELTEAITVLTDGFVPDEVYAQAAAHFDENELAHLIGAITVINAWNRLSVAARNVPGHYVPGSLG
>NZ_CP016824.1|WP_067412574.1|2543114_2544542_-|PLP-dependent-aminotransferase-family-protein
MTESWANLGIDLHLEPAGPGLRKGLTDALREAVRSGRLAPGTRLPSSRTLAGDLGIARNTVADAYADLVAEGHLTARQGSGTRVAEQAGPASSVPRRQRPVRVPERAGPAHDLTPGTPDLSAFPRAAWLKAARRALTAAPNDAFGYGDPRGRPELRAALTEYLARVRGVAADPERIVVCAGVAHGLKLVTEVLAARGGHGGRQGSGTVAVETYGLRFHREWLAEEGVGTVPLPFDADGTDPAGLDGERAVLLTPTHQFPMGGTLSPARRAAVVDWARRTGGLILEDDYDGEFRHDRRPVGALQGLAPDRVAYFGTASKALAPGLRLGWLVLPPGLVDEVLAAKGYADTCGAPDQLTLAEFLTSGAYDRQVRLMRLRYRRRRDELVATLARRAPSVRVGGIAAGLHAVLLLPPGTESEVLRAAAWHGLGVQGLSWFRHPDAEAAGRPVPEGLVIGYGRPPDHAWQSALETLCRCLP
>NZ_CP016824.1|WP_018894285.1|2542251_2542830_-|hypothetical-protein
MAENITVPAVRALDAPVARPATGPGRGAAPQGVPVADERPPAPVRLTKSGAGEPGSGSGEPSAEQRRKKAARRRVRSSTVALGSMGVLAAALAACGSEPDRRCVDRNSYSYGGGYKVVDSSQCRNGSSGSTGGTGGGGSSGGSGRYGSDRSSNAGWYYGGDSKSGYASDGSFNKSSVSSGGFGCSGKGSGGG
>NZ_CP016824.1|WP_067412573.1|2540887_2542108_-|glutathionylspermidine-synthase-family-protein
MQRHTIEPRPGWQETVEAQGVIYPLTRHPDDSLRPYWDESAYYSFSLAEVEALEEVVEELHAMCLAAAAHIVEKDRFAELGITDPRLASLVTEAWHRKAELPSLYGRFDLWYDGSGAPAKMLEYNADTPTSLVEAASAQWFWMEERFPGADQWNSLHERLVDAWRAQAALLPPGSPVHFAHTIDDECGEDLMTVAYLRETAAQAGLETEAIAVEDIGWDSLSHRFVDQRLRFIRSCFKLYPWEWLATDDFGPHVLDTLDNGGGTGSTLWIEPAWKMLLSNKALLAILWELYPGHPNLLASYLDGPRELATTTGYVTKPLLGREGAGVTLHQPGGTQTPASATGPSCYQQLALLPDLSTPAPGAHSPTNHVVLGAWVVADEAAGLGIRESAGPVTDGYARFLPHVIL
>NZ_CP016824.1|WP_067412570.1|2540310_2540844_-|GNAT-family-N-acetyltransferase
MPELQRLRADHAPALLAFERENRAWFARTISDRGDAYFADFPARHRALLTYQDEGTDHFHVLVADDATTILGRFNLMDITDGQAELGFRMAESATGRGLATEAARTVCHLAATAYALTSLRAQANLDNLASHTVLTRTGFTATEQTVLRNGTAGRRYVKELAGPEEGAARAIGAAGL
>NZ_CP016824.1|WP_010638599.1|2550710_2551961_+|sugar-ABC-transporter-substrate-binding-protein
MHRVARTATAVIAASTALAVVTACGGSSGTEVAADAEQTLTVWAMGAEGEKLAEVAKEYEKENPHLKVKVTPVGWDVAHQKLVSAAAAGNLPDIAQMGGSYLGEFAELGVLEPVDTKRFQEKDFFPAGWQQGEVDGEVYGVPWYVDTRVLYYRTDLAEKAGVDKAPADWKELRALASAYQKDAGTKWGLSIQPSGLDTVQSFYPFLYSAGGEIIDEDGKVVVDSPAAVKALKEYGAYFDKGLANKSVPPGYDVVKDFGNGRVPMFFGGPWHVTLLNEGQPDIKGKWAVAEVPADEASVSMAGGSSLTVSKDSPHKAAAEEFIAHLTSTEGQADWYERTKDLPANTTAWESGSLADDPALKVFEKQMKTAKASPTLANLSEITDKVDQAIAQVTQGKATAEEALGKAKDQIEGLVQK
>NZ_CP016824.1|WP_003948480.1|2551966_2552917_+|sugar-ABC-transporter-permease
MSTTTRKADEAAPGGRRPGRRRGSLGVQNAAGWLFSTPFLVLFAVFMAFPIVATLLMSFTDFGLGNVTRPLDARFIGFENYTRLFGDERFLKSLFNTAYFVVVGVPLTIGLGLLVAVLLNNGIDRARTFFRVGFYAPVVTSIVAVAVVWRFVLDPSDGLIAGLASEVGLTAPDFLGSEALAMPSLIAMAVWRNLGTVMVLFIAGLQAIPTEVREAARLDGVGPWQELRRITIPLLRPTLLYASVITTIGYLNVFEEPFVMTQGGPSDSTLTVSLNMYREGFNFFHMGYASAMAYVLFVVIMGITVLQLRLLKDNTR
>NZ_CP016824.1|WP_003948481.1|2552913_2553747_+|carbohydrate-ABC-transporter-permease
MSAEGRVRRPLTYVLLSGGLLVMAAPFLWMGLSAFKTQRELSASPPVWIPSQWTLANFRQLLADLDLPLYFMNSVIVAVLVTVSNLVFCSMLGYALAKLNFAGRNKVFGVVLGALMVPGNLMLLPLFVLMSKLQLIDSYAGLVLPFAAGAFGVFLMRQFMQSIPDELLEAARMDGAGEWFIFWRIVMPLVKPALATLAILTFLGSWNNFVWPLIATNDPDKYTLPVALATFATDPNKAGGSNGVLMAGSFLIVLPVLAVFIALQRHFTQGIATAGMK
>NZ_CP016824.1|WP_008410772.1|2553814_2555008_+|family-1-glycosylhydrolase
MTSTPFPEGFLWGASTAAHQIEGNNTDSDWWVKEHTAGTHIQEPSYDACDSYHRWPEDMDLLASLGFTDYRFSIEWARIEPVEGHFSRAELAHYRRMVEGAIERGLRPMVTLHHFTVPQWFEARGGWTAEGATELFARYVAACAPVIATGVAHVCTINEPNMIAVMAGQAKRGDIGFPPAGLPTPDEETTHAVIAAHHAAVKEVRAISSGIKVGWTIANQVYQALPGAEEVTAAYRHPREDVFIEAARGDDWIGVQSYTRTRIGADGPIPASPEAERTLTEWEYYPTAVGHALRHTAEVVGDVPLIVTENGIATADDERRTAYYTGALGEVAAAIEDGLKVEGYLAWSALDNYEWGSFRPTFGLIAVDWETFERTARPSAVWLGSLGRTRELPGRAV
>NZ_CP016824.1|WP_067412590.1|2555104_2556625_+|VCBS-repeat-containing-protein
MAWMRRPDTPTTRRGRSGRAAASLAAALLVSGGLSAAALAPTTALAADGPAAASADDFNGDGYADLVSGAPGGTVSGKAGAGYVAVTYGSAKGLAPAPGTVVSRSTAGVPGAATAKQRFGETFAKGDLDGDGYSDLVIGSATAEPGAVILWGSPKGLTGGTAVAGFGQAPQVGDFDGDGQADLALFGAAQVAGDDPVTQEARLLKGPLTRQGTPDEQLDFLDRSEWWGYDSDGPACAEDDSCVDGPTSVGGPVRPKAVGDVNGDGSDDLVTWLYEGDGVWAHHLFTGSATGFRDAQEAGPIGSSGDDAAVGVGDVDGDGYDDVVTGSGEATAKVTVRYGSAAGLEGREQAFDQSLPGLHGAQKKGDHFGSCVAVADVTGDGRAEIALGISGEDFSGLTDAGSIALLHGTASGVTGEGSQVLHQNTAGVPGVAESGDKFGSACALLDTDGDGHRDLVAAAAEENEQAGAVWALRGTGEGLTVEGASAFGPGHVGGPVTKAKFGSFLR
>NZ_CP016824.1|WP_067412593.1|2556685_2557150_-|VOC-family-protein
MAEKSFPAPESGMLLSYFLTVADVPRSRAFYSEVLGGEVILEENPCTVRLANSWLIMNPGGGPTPDKPGITLHPPEDPATATCFLNIRVADIQAVYEEWSAKGAEFVTPPIDRKAEIRCYLRDPDGYLIEIGQATGMLHGVYADPPAGKGPVTR
>NZ_CP016824.1|WP_003948485.1|2557346_2558324_-|ABC-transporter-substrate-binding-protein
MRIRPSRRATRTAAALTASGALLAVAGCGAADMTQQASPYANAGDGKSVTLSLQSWVGAQANVAVAQYLLEHELGYRVDTVQIDEVPAWDALSQGRVDAILEDWGHPEEEKRYVDDKKTITAAGDVGVTGHIGWFVPTYFAKKHPDVTNWKNLNKYADQLRTPESGGKGQLMDGSPSYVTNDKALVKNLDLDYQVVFAGSEAAQITQIKQFAKEKKPFLTYWYQPQWLFEKVPMTEVELPKYEEGCDADPDKVACAYPETPLQKYLNTDFAENGGEAAEFLKNFEWTTEDQNQVSLWIADQKMDPQKAAEKWAKANESTWKKWLP
>NZ_CP016824.1|WP_067412595.1|2558325_2560320_-|ABC-transporter-permease-subunit
MAATTAPTTGAAAPPGSTGAGLAGLARRHPALTKLLALAVLAAVLVPLAHARWASGSWPEALTVDVSGPLGSASDWIIDNRDSHPLFLYFFGHVSNAVVLSVRAVYLVLLAGGWAGVTVAAGLIAWRVAGVKLAVGTAVAFLLCGVLGMWVPTMQTLALMIVAVLASVILGALLGLAAGLSDRVFRLLRPVLDTMQVLPAFAYLLPVVLVFGIGVPAAVLATVIYAAPPMARLTALGLRGADAGVMEAVTSLGTTARQRLFTARLPLARKELLLGVNQTIMLALSMAVIASVIGAGGLGDRVYQALASVDVGAALAAGIPIVLLAVVLDRTTAAAGRRIGAGEAASGPVPPAVGWAVAAVATLAVALGTRFASALEWPATWTYGIAEPVNRAVDWMTDHLYSGVPLIGGTADWAGHFTTWVLDPVRDGLQWLPWWGLLLIVAALAWLIGTWRTALTATLAMAAIGVLGVWNPSLDTLSQVLAAVAVTLVLGFATGIAAARSNRVEAALRPVLDVFQTMPQFVYLIPVVALFGVGRAPAVAAAVVYALPAVVRITTQGLRGVDAGALESARSLGATSGQQIRQVQLPLARSSLLLAVNQGVVLVLAVVIIGGLVGGGALGYDVVFGLAQGDLAVGLVAGAAIVCLGLMLDRVTQPTERRTTTKGA
>NZ_CP016824.1|WP_003948487.1|2560319_2561441_-|glycine-betaine/L-proline-ABC-transporter-ATP-binding-protein
MSATTTATPPGREAPADENTPVFSVENLWKVFGPKAERVPADPALAALDPVELRAATGCTAAVHDVSFDVRQGEVFVVMGLSGSGKSTLVRCLTRLIEPTAGKLAMYGEDVRAMDKNRLRELRRRRAAMVFQHFGLLPHRTVLDNVAYGLEIQGVPRAERRAKAAETAALVGLEGLEDRRPGQLSGGQQQRVGLARALAVDPEVLLFDEPFSALDPLIRRDMQEEVKRLHQEEGRTMVFITHDLSEALRLGDRIALMRDGRVVQLGTPEEIVGSPADDYVRDFVRDVPREQVLTVRTAMRPATGSEAEQGPALSPGATVSEAIEAVARTGETARVVDSGRCLGVVDHHRLLGVVAGADPGPAAPPAKAGEAVL
>NZ_CP016824.1|WP_067412598.1|2561437_2562955_-|oxidoreductase
MPTYDYVVIGGGTAGSVIASRLTENPDTTVAIIEGGPSDIDRPDVLTLRRWMGLLGGDLDYDYPTTEQPRGNSHIRHSRAKVLGGCSSHNTLIAFKPLPPDWDEWETAGAEGWGAVPMEAYYARLKNNIVPVDEKDRNAIARDFVDAAQGALGVPHVDGFNQKPFSEGVGFFDLAYHPENNKRSSASVAYLHPYLDRPNLHLMLETWAYQLAFDGDRATGVHVRTKDGEEILVEAGREVLLCAGAVDSPRLLLHSGIGPRADLEKLGITVRHDLPGVGENLLDHPESVIVWETDGPIPENSAMDSDAGLFVRRDPKGRGPDLMFHFYQIPFTDNPERLGYERPAHGVSMTPNIPKPHSRGRLYLTSADPEVKPALDFRYFTDEDDYDAQTLVDGIKIARRIARTEPLAGWLKREVAPGPGITDDEALSEYARKVAHTVYHPAGTCRMGAEDDELAVVTPELKIRGLTNIRIADASVFPTMPAVNPMIGVLMVGEKCAEMLGGDAR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP016824_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_10

2622069-2622157

Orphan

Consensus_repeat	Method
TCACCATGGAGCCATGACCCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_10

>merge|NZ_CP016824|10|2622069-2622157|CRISPRCasFinder
TCACCATGGAGCCATGACCCGGCTCCGCCCAGGGTCGTACCGGCTGCCCGCACGCCGCGCGCCCCGTCACCATGGAGCCATGACCCCGC

>NZ_CP016824|10|10|2622069-2622157|CRISPRCasFinder
TCACCATGGAGCCATGACCCGGC	TCCGCCCAGGGTCGTACCGGCTGCCCGCACGCCGCGCGCCCCG
TCACCATGGAGCCATGACCCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_031177128.1\|2615015_2615507_-\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176862
NZ_CP016824.1\|WP_049978235.1\|2625372_2625912_-\|DoxX-family-membrane-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP016824.1\|WP_059212562.1\|2613567_2614542_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NZ_CP016824.1\|WP_067412687.1\|2623833_2624037_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412695.1\|2630837_2631170_+\|chorismate-mutase	unknown	unknown	gnl\|CDD\|236117
NZ_CP016824.1\|WP_067412673.1\|2614683_2615019_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_008412747.1\|2612767_2613400_-\|DUF4232-domain-containing-protein	unknown	unknown	gnl\|CDD\|379419
NZ_CP016824.1\|WP_008416140.1\|2626844_2628257_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003948537.1\|2619891_2620599_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP016824.1\|WP_003948547.1\|2628784_2630377_-\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NZ_CP016824.1\|WP_079165326.1\|2624160_2624904_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP016824.1\|WP_018468463.1\|2620715_2621957_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|226951
NZ_CP016824.1\|WP_067412698.1\|2631893_2632937_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237284
NZ_CP016824.1\|WP_067412692.1\|2624900_2625371_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240032
NZ_CP016824.1\|WP_067412679.1\|2617993_2619784_-\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_CP016824.1\|WP_067412677.1\|2616978_2617278_-\|DUF4333-domain-containing-protein	unknown	unknown	gnl\|CDD\|379513
NZ_CP016824.1\|WP_067412684.1\|2623423_2623651_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003948545.1\|2626013_2626766_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|180411
NZ_CP016824.1\|WP_030767622.1\|2615685_2616918_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|379140
NZ_CP016824.1\|WP_031177126.1\|2617369_2617945_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226426

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_031177128.1\|2615015_2615507_-\|SRPBCC-family-protein	gnl\|CDD\|176862	cd07820, SRPBCC_3, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	4.79669e-47
NZ_CP016824.1\|WP_049978235.1\|2625372_2625912_-\|DoxX-family-membrane-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	1.67202e-07
NZ_CP016824.1\|WP_059212562.1\|2613567_2614542_-\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	9.57352e-74
NZ_CP016824.1\|WP_067412698.1\|2631893_2632937_+\|hypothetical-protein	gnl\|CDD\|237284	PRK13108, PRK13108, prolipoprotein diacylglyceryl transferase; Reviewed.	4.57796e-05
NZ_CP016824.1\|WP_067412695.1\|2630837_2631170_+\|chorismate-mutase	gnl\|CDD\|236117	PRK07857, PRK07857, chorismate mutase.	4.42777e-32
NZ_CP016824.1\|WP_008412747.1\|2612767_2613400_-\|DUF4232-domain-containing-protein	gnl\|CDD\|379419	pfam14016, DUF4232, Protein of unknown function (DUF4232). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.	2.06174e-21
NZ_CP016824.1\|WP_003948537.1\|2619891_2620599_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.73592e-56
NZ_CP016824.1\|WP_003948547.1\|2628784_2630377_-\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NZ_CP016824.1\|WP_079165326.1\|2624160_2624904_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.07436e-05
NZ_CP016824.1\|WP_018468463.1\|2620715_2621957_-\|ATP-binding-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.66726e-19
NZ_CP016824.1\|WP_067412692.1\|2624900_2625371_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240032	cd04676, Nudix_Hydrolase_17, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	5.33452e-54
NZ_CP016824.1\|WP_067412679.1\|2617993_2619784_-\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	0
NZ_CP016824.1\|WP_067412677.1\|2616978_2617278_-\|DUF4333-domain-containing-protein	gnl\|CDD\|379513	pfam14230, DUF4333, Domain of unknown function (DUF4333). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 140 and 255 amino acids in length. There are two completely conserved C residues that may be functionally important.	9.1642e-12
NZ_CP016824.1\|WP_003948545.1\|2626013_2626766_-\|SDR-family-oxidoreductase	gnl\|CDD\|180411	PRK06123, PRK06123, SDR family oxidoreductase.	2.81002e-76
NZ_CP016824.1\|WP_030767622.1\|2615685_2616918_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|379140	pfam13360, PQQ_2, PQQ-like domain. This domain contains several repeats of the PQQ repeat.	5.02119e-19
NZ_CP016824.1\|WP_031177126.1\|2617369_2617945_-\|AAA-family-ATPase	gnl\|CDD\|226426	COG3911, COG3911, Predicted ATPase [General function prediction only].	6.42313e-37

>NZ_CP016824.1|WP_018468463.1|2620715_2621957_-|ATP-binding-protein
MPDAAAGTIEQEREPRKLYRSSDGRWLGGVARGLAGHLGLPVFWVRLAFVALFVANGLGALLYAAFWSFVPLGVGGLSPQPPSAPAKADRGQLVALLALLVASMVFVASVDLNGTARAYLFPALLVGAGVAVVWRQADNARRARWAEAGRRRRNLTLARSAAGVLLVGAGVSGMFVIQGSAEHLGAVLQASLAVLVGVALLAGPWLVRMAQDLGQERLMRIRAQERAEVAAHVHDSVLHTLTLIQRNADRPAEVRRLARSQERELRNWLHRPEGSGRAAEDEPATLAEAVKRTAAEVEDKHGVPLEVVLVGDCPLDEPLPALIQAAREAMVNAAKYGGEGGPVQVFAEVSGPEVFVSVRDRGPGFDLDAVPADRMGVRESIIGRMERHGGTARLRSAPDGGTEVELEMKRTTS
>NZ_CP016824.1|WP_003948537.1|2619891_2620599_-|response-regulator-transcription-factor
MSDETTAGGGAGEDGGRRVRVVLVDDHRMFRTGVQAEIGQTEETGVEVVGEADDVDQAVTVITATRPEVVLLDVHLPGGGGVEVLRRCAPLMGAAERPVRFLALSVSDAAEDVIGVIRGGARGYVTKNITGADLVDSIFRVQDGDAVFSPRLAGFVLDAFASTDAPPVDEDLDRLTQREREVLRLIARGYAYKEVAKQLYISVKTVESHVSAVLRKLQLSNRHELTRWATARRLV
>NZ_CP016824.1|WP_067412679.1|2617993_2619784_-|BCCT-family-transporter
MSTTDTDLPPDSPHGPTSAEPPGADSRPDVPVVAIGVLGVLGVVLWASLGKGSFKSFSDSALPWVLKNFEWLFVIAADVFLILCVILAFSRFGRIKLAREGDDEPEFTDFAWVAMMFAAGMGIGLIFYGVGEPVAHYLSPPPSTDATAGTPEAAGRALEYSFFHWTLTPWAIYGVVGLSLAYTTFRLGRGNRISAVFIPLIGERLANGVIGRLLDLLAVFATVFGTATSLGIGALQIATGLQLTAGVENTTGLQLLIIVVLGAAFVISAFTGLHGGVKWLSSVNLVMAALLMLFIFVVGPTVYILDAIPSSIGGYFNELISMATRTGAFTDSEWLGQWTIFYWAWWLSWAPFVGTFIARISKGRSIREFLLAVLLIPSGASAVWFCVLGGTGIRLDETGVVDMAEKESEGTEATLFSMLDALPIGQVTSWFAMVLIMMYFITSADSASLVMGSLTSRGALHPRAWLNVTWGVLMAAVAAALLIAGGLDSLQSATILVALPFVVVMLGLCWATVRELREDPGAGRRRHQALHGLRDAVRKMIGEAMSEGRNDPTAHPRLRRAARSRAQGETGPAETPDRGADRGTERGPDQTPPDKE
>NZ_CP016824.1|WP_031177126.1|2617369_2617945_-|AAA-family-ATPase
MRHHILTGTPGAGKTTVLRALASRGHRTVAEAATDVIAREQALGDPEPWTGPEFIARVTAEQRARQEAAAGAPGPCFFDRSPVCTHALATYLGHPVPPALTAELTRLTTPPGLYEPYVFLLRPLGFVEPTAARRISYEDALAFERVHEESYRRFGFRLVEVPAAGVEERVDRILEVVGAEEDRGGGARRWW
>NZ_CP016824.1|WP_067412677.1|2616978_2617278_-|DUF4333-domain-containing-protein
MAAAAVAVLLGAGCSVNVSSGGSVGKDEVAKQAKTALGEQVGQEPDSVTCEDDLKAEKGATVRCQLAADGEQYGVTVTAKSVTGGTVQMDFKVDDAPGG
>NZ_CP016824.1|WP_030767622.1|2615685_2616918_+|PQQ-binding-like-beta-propeller-repeat-protein
MANTTVGGTSRRRVLRLAGGGLALAALGAGAAGCREDDVDDPAARGDKPAGSGEPSAGEGGGEDGKAPKALWSQSVPAETYGDNDELVAVAGMVIASGSPLSARDAATGEERWSLPDGVAPGAPLLLGDGTLYLASGKYDGTVSGYDPASGKETWQGRLGKEYRQPRPIAVDARQVYVVAEILEKDNSSHTNLIAALDAGSGKIVWSERRDLGTEQNGIHAAVQGRHLVYTDFKKNLTVRDTGTGRQVWTQKTEKTNYGFFTVHEDLVIVPQGDRLHAYALADGARKWTVKAAHLTTFKEPAVVDGVLHIADSARTVRALDPATGKEIWQSKALAEAGFQVPRQYVKAGKLLCVATDLDKDGGVAALDAATGELRWTFNDGTGDYHAWLVATDGKRVFALHGKKLHALPV
>NZ_CP016824.1|WP_031177128.1|2615015_2615507_-|SRPBCC-family-protein
MTRFELETRIAAPVPLVFGLSLDVDAHTASMARSGERAVAGVTGGAMALGDTVTWRARHFGVVWRMTSRITAYDHPTHFVDEQTAGPFHHWWHAHHFTPDGHGGTLMRDEITFQAPLGPLGRLAERAALDRYMPHLMRERNAHLRAVAEREAGGAPGRGAGGG
>NZ_CP016824.1|WP_067412673.1|2614683_2615019_-|hypothetical-protein
MTWLGYASGAPHAVDVTPAGIPVVGAVMALGVLAFLVWDALRAPGEPWFRWLVPAGFCLALPAVARQWLPLLAVAALLMGAGMALSNYWRWTRRRRARRPSPRAKLPPLDL
>NZ_CP016824.1|WP_059212562.1|2613567_2614542_-|alpha/beta-hydrolase
MASQLPPPPDPYLETAAKELAEATDPHPRIYEVPPAQGRDILAGLQSGEGVERPEVDEEWVTVDAGQWGEVRTRIIRPKGATGPLPVVFYIHGAGWVFGDENTHDRLFRELTVGAGAAGVFPVYDRAPEAQYPTQVEQNYAVGQWVLRHGAEHGLDTSRIAVTGESVGGAMSAVFAIMNKERAGIDLKAQVLLYPVANADFGTPSYLQFAEGYYLTRDEMKWFWDQYAPNPAQRTEVYASPLQATTEQLRGLPPALVITDEADVLRDEGEAYAARLREAGVDVTAVRVAGMVHDFLLLDSLRDTRAANVARHLAIDALTKALHD
>NZ_CP016824.1|WP_008412747.1|2612767_2613400_-|DUF4232-domain-containing-protein
MWGAALALACAAALTACGPDGGDADAAGAASDAPTSPAATPTGTGTPAEPAPSSPPPTTSAAPSASAKPGGIARCETDGLALSLVANGQEMNSKYFDLRLTNTGSEPCDLLGHPGVSLLDAGGKRVGEPATRSQDGTGDGGAVRLRPGQAAHATVKTAGEGVTDGRCWPEAATLLVYPPGSRQTVTTADLAGLKVCGDSFQVGPVGDRAP
>NZ_CP016824.1|WP_067412684.1|2623423_2623651_+|hypothetical-protein
MLRHEPQPGRLLAGLVLITAAVLYTGDAVSAWSIPWWVLFPLVCGGLWLAAAVGVFGHLVRRRRKRKVGDRAGSC
>NZ_CP016824.1|WP_067412687.1|2623833_2624037_-|hypothetical-protein
MAEPRTYPSPPVELPIDPWLLEGSPAPRCKVCAALAHEREEALAHGDRSKAYEVSREIRNHQHVGVG
>NZ_CP016824.1|WP_079165326.1|2624160_2624904_+|helix-turn-helix-transcriptional-regulator
MVGNERLRAAMATRGWTHAALAAVVGVDPKSVERWVNLGRVPRKVTAVKAAQALQENAHELWPALRQPRSARAVSPELVALYEQRADLPVSVFIDLLSSARERIQFLVYAALFLHEAYPRLNTLLREKAEAGCRVQICSGDADSPNVRLRGEEEKFGHGIESRCRLALLHYRPLLDVPGIEIRTHGTTLYNSMFRADDQMLVNAHVWGVNAYGAPVWHLRHAEGATMFKGYAESFDAVWSTAREVQQ
>NZ_CP016824.1|WP_067412692.1|2624900_2625371_+|NUDIX-domain-containing-protein
MTRTEYYDDPHAPQPNSLVVAASAVVTDDQGRVLMQRRADSGLWALPGGGMELSDTLPGTAVREVKEETGLDVEITGLVGTYTDPRHVIAYPDGEVRRQFNVCFRARLVGGTLTVSDESLALRWVTPADLDALEMHPTQRLRLSHFLEGRDAPYLG
>NZ_CP016824.1|WP_049978235.1|2625372_2625912_-|DoxX-family-membrane-protein
MAHGTLLEQPGGLGPRRGVRATLRRYALLPLRVFLGITFTYAGLDKLTDSAFLSASGPGSLGELLDNVRPTAGAPFLIDLAQHSPTAFGYALAIGELLVGLATLLGLWARVAATGGALISLVLWLTVSWSATPYYYGNDLPYLMAWLPLILAGAEHFSADNALRLRRRRGLDMGLGVGD
>NZ_CP016824.1|WP_003948545.1|2626013_2626766_-|SDR-family-oxidoreductase
MTTTTGTSSRQPLTVVTGGSRGIGAAVCARLAADGHDLVVGYRSDRAAAEAVAERVRAAGRRALAVAVDTADAASVDALFDEAATLGTVTGLVNNAGMSGPVGRLADADPAGLSRALDVNVLGYLLCARRAVRDLAASGGGALVNISSAAATLGSPGEYVHYAAAKAAVDTLTVGLAKEVAEDGIRVNCVAPGVIWTEFHADPERPAKQAPGIPLGRAGQPEEIAAAVSWLLTADASYTTGAVLRVAGGR
>NZ_CP016824.1|WP_008416140.1|2626844_2628257_-|hypothetical-protein
MAGREAGNTADDTSGAGVTPAPGHPTDEAPPPVPHQAGAPDDKPAPGEPAGEAEQADAPHPHTCTCPVCPRGTRAAHREAQAAFRARRDALAAGEGLPAAVSYSAGASRQWISDELTQAAREVGARARAEAEGWYVLLWRRTVYVVWGTVAALFLGQVATAFTAGWTAARTAGLLAALLGGGLLTGAAHLHGRRGGVLAPVIGEDNRLSTSRAVAAFWVLLTAYAVLVLAGRLAFASGDGERDTLLAGLDLARGAGLVTVLAVTCAVAVVVRRVVAVRVQGQRLQKAQAPRPRAADLLTDDSGRAHFADTQYVLVSAVAVVYALVRLARRPDQLPDLPWGLALLVLVSAATYLASKYAEGSRPVIHAVVRAREAGDLDGPIRTGDDIEIRGAGFLPPSARTPDRLARMVVRIGAVHVHVPLVPVPGGFTNPSDTTLIVPVPVEVEPGKAEVQLVSAAGVETNKVTIEVGD
>NZ_CP016824.1|WP_003948547.1|2628784_2630377_-|glutamine-hydrolyzing-GMP-synthase
MPSASPASPAAAETVLVVDFGAQYAQLIARRVREARVYSEIVPSTMPVSEMLAKNPAAIILSGGPSSVYAEHAPTLDRALFEAGVPVFGMCYGFQLMAQTLGGTVDNSGAREYGRTELTVSKSGSTLFEGTPDEQSVWMSHGDACSAAPEGFAVTASTAVVPVAAFENDEKKLYGVQYHPEVMHSTHGQQVLEHFLYRGAGLSPTWTMGNVIEEQVAEIRARVGTKRAICGLSGGVDSAVAAALVQKAIGTQLTCVYVDHGLMRKGETEQVEKDFVAATGVQLKVVDAEERFLTALAGVSDPEQKRKIIGREFIRVFEQAQAEIVAEAAGEGEDVAFLVQGTLYPDVVESGGGTGTANIKSHHNVGGLPDDIEFELVEPLRMLFKDEVRMVGQELGLPEEIVQRQPFPGPGLGIRIVGEVTKDRLDLLRDADAIAREELTAAGLDRDIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRMPYDVLARISTRITNEVAEVNRVVLDVTSKPPGTIEWE
>NZ_CP016824.1|WP_067412695.1|2630837_2631170_+|chorismate-mutase
MTTTTTAVTATTDATASDRPAERTGARTPEAAELIGGARERIDALDDRIIGLVQERIAVSAVIQEARISSGGRRVNLSREMEILSHYRDALGPPGTSLAMTLLELSRGRA
>NZ_CP016824.1|WP_067412698.1|2631893_2632937_+|hypothetical-protein
MAVAAATAVISPVALLAAPAAFATDGQQDGQTSEITPAPTASESETTAPEEPAEPPTTAPEESEPAPAESESAAKETPGTEEPGTEPTEGTEEPSEDPEPSPSESDDEDEDPDDGYEICLDEDGNELGDLGVSVSGLPGQVRAGSTHEFTLSAANSGETTLESVEWGAMIANENDDLGLEDGSLLSHVDLAFYDPESGRWISFYDSFGVGLAFGETTLKAGQTIDIKLRMTVAKDAPLGAGYAFGFTGYVNEEENCVTEAYAFYDFTVIGASATPKPGDAKENEGKKPQGGLKPIEEKKTLEPTGQLAETGAGSMLPVIGLVGGVTVLAGTGVVFAVRRRGGVGTAA

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP016824_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_11

2661257-2661432

Orphan

Consensus_repeat	Method
CACCAAACCCAGCCCGGCCGGCGCTTGAGGCCACC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP016824_11

>merge|NZ_CP016824|11|2661257-2661432|PILER-CR
CCAACCTCAGCCCGGCCGGCGCTTGAGGCCACCCCACCACAGCCCCTTGCGGGCTGACACGTACGCCGGAAGCCTCGGCCACCACTCCCAGCCCGGCCGGCGCTTGAGGCCATCGGTGACCGGCACGGTCAGACGTGTCCGCACCAAAACCAGCCCGGCCGGCGCTTGAGGCCACC

>NZ_CP016824|11|1|2661257-2661432|PILER-CR
CCAACCTCAGCCCGGCCGGCGCTTGAGGCCACCCC	ACCACAGCCCCTTGCGGGCTGACACGTACGCCGGAAGCCTCGGCCA
CCACTCCCAGCCCGGCCGGCGCTTGAGGCCATCGG	TGACCGGCACGGTCAGACGTGTCCGCA
CCAAAACCAGCCCGGCCGGCGCTTGAGGCCACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_003948579.1\|2666704_2667121_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341390
NZ_CP016824.1\|WP_003948566.1\|2652795_2654304_-\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|376340
NZ_CP016824.1\|WP_003948568.1\|2655293_2655905_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP016824.1\|WP_067412725.1\|2662756_2663965_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|380115
NZ_CP016824.1\|WP_107436714.1\|2668741_2669263_-\|ribosomal-protein-S18-alanine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|273701
NZ_CP016824.1\|WP_067412730.1\|2664714_2666085_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP016824.1\|WP_067412732.1\|2667612_2668749_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl\|CDD\|236585
NZ_CP016824.1\|WP_067412738.1\|2669307_2669970_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	unknown	unknown	gnl\|CDD\|274750
NZ_CP016824.1\|WP_003948572.1\|2658798_2660421_-\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP016824.1\|WP_067412719.1\|2656350_2656695_+\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP016824.1\|WP_008414818.1\|2667340_2667616_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_008413971.1\|2657894_2658707_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NZ_CP016824.1\|WP_003948564.1\|2650208_2651474_+\|nucleotide-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|223749
NZ_CP016824.1\|WP_003948573.1\|2660578_2660887_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NZ_CP016824.1\|WP_003948567.1\|2654465_2655041_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236607
NZ_CP016824.1\|WP_067412727.1\|2664070_2664718_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378968
NZ_CP016824.1\|WP_003948570.1\|2656858_2657755_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NZ_CP016824.1\|WP_003948578.1\|2666115_2666595_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412722.1\|2661715_2662654_-\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213022
NZ_CP016824.1\|WP_003948565.1\|2651565_2652693_-\|GuaB3-family-IMP-dehydrogenase-related-protein	unknown	unknown	gnl\|CDD\|236322

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_003948579.1\|2666704_2667121_-\|CBS-domain-containing-protein	gnl\|CDD\|341390	cd04622, CBS_pair_HRP1_like, CBS pair domain found in Hypoxic Response Protein 1 (HRP1) -like proteinds. Mycobacterium tuberculosis adapts to cellular stresses by upregulation of the dormancy survival regulon. Hypoxic response protein 1 (HRP1) is encoded by one of the most strongly upregulated genes in the dormancy survival regulon. HRP1 is a 'CBS-domain-only protein; however unlike other CBS containing proteins it does not appear to bind AMP. The biological function of the protein remains unclear, but is thought to contribute to the modulation of the host immune response. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	1.22068e-35
NZ_CP016824.1\|WP_003948566.1\|2652795_2654304_-\|IMP-dehydrogenase	gnl\|CDD\|376340	pfam00478, IMPDH, IMP dehydrogenase / GMP reductase domain. This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.	0
NZ_CP016824.1\|WP_003948568.1\|2655293_2655905_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.73082e-50
NZ_CP016824.1\|WP_067412725.1\|2662756_2663965_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|380115	pfam18096, Thump_like, THUMP domain-like. This is a domain of unknown function found in bacteria.	1.53603e-18
NZ_CP016824.1\|WP_107436714.1\|2668741_2669263_-\|ribosomal-protein-S18-alanine-N-acetyltransferase	gnl\|CDD\|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR\|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	1.95639e-31
NZ_CP016824.1\|WP_067412730.1\|2664714_2666085_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.33295e-13
NZ_CP016824.1\|WP_067412732.1\|2667612_2668749_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl\|CDD\|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	2.58871e-178
NZ_CP016824.1\|WP_067412738.1\|2669307_2669970_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	gnl\|CDD\|274750	TIGR03725, T6A_YeaZ, tRNA threonylcarbamoyl adenosine modification protein YeaZ. This family describes a protein family, YeaZ, now associated with the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family may occur as fusions with ygjD (previously gcp) or the ribosomal protein N-acetyltransferase rimI, and is frequently encoded next to rimI. [Protein synthesis, tRNA and rRNA base modification].	2.08408e-64
NZ_CP016824.1\|WP_003948572.1\|2658798_2660421_-\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP016824.1\|WP_067412719.1\|2656350_2656695_+\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.73842e-27
NZ_CP016824.1\|WP_008413971.1\|2657894_2658707_+\|SDR-family-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	4.28598e-81
NZ_CP016824.1\|WP_003948564.1\|2650208_2651474_+\|nucleotide-sugar-dehydrogenase	gnl\|CDD\|223749	COG0677, WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane].	1.59681e-121
NZ_CP016824.1\|WP_003948573.1\|2660578_2660887_-\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	3.64761e-49
NZ_CP016824.1\|WP_003948567.1\|2654465_2655041_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236607	PRK09648, PRK09648, RNA polymerase sigma factor ShbA.	2.14712e-89
NZ_CP016824.1\|WP_067412727.1\|2664070_2664718_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	5.75637e-10
NZ_CP016824.1\|WP_003948570.1\|2656858_2657755_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.41333e-56
NZ_CP016824.1\|WP_067412722.1\|2661715_2662654_-\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	2.47748e-35
NZ_CP016824.1\|WP_003948565.1\|2651565_2652693_-\|GuaB3-family-IMP-dehydrogenase-related-protein	gnl\|CDD\|236322	PRK08649, PRK08649, GuaB3 family IMP dehydrogenase-related protein.	0

>NZ_CP016824.1|WP_003948573.1|2660578_2660887_-|co-chaperone-GroES
MTTASSKVAIKPLEDRIVVQPLDAEQTTASGLVIPDTAKEKPQEGVVLAVGPGRFENGERLPLDVKTGDVVLYSKYGGTEVKYNGEEYLVLSARDVLAIIEK
>NZ_CP016824.1|WP_003948572.1|2658798_2660421_-|chaperonin-GroEL
MAKILKFDEDARRALERGVNQLADTVKVTIGPKGRNVVIDKKFGAPTITNDGVTIAREVECDDPYENLGAQLVKEVATKTNDIAGDGTTTATVLAQALVREGLRNVAAGASPAALKKGIDAAVAAVSAELLDTARPIDDKSDIAAVAALSAQDKQVGELIAEAMDKVGKDGVITVEESNTFGVDLDFTEGMAFDKGYLSPYMVTDQERMEAVLDDPYILIHQGKIGSIQDLLPLLEKVIQAGGSKPLLIIAEDVEGEALSTLVVNKIRGTFNAVAVKAPGFGDRRKAMLGDMATLTGATVIAEEVGLKLDQAGLDVLGTARRVTVTKDDTTIVDGGGNAEDVQGRVAQIKAEIESTDSDWDREKLQERLAKLAGGVCVIRVGAATEVELKERKHRLEDAISATRAAVEEGIVSGGGSALVHAVKVLDDNLGRTGDEATGVAVVRRAAVEPLRWIAENAGLEGYVITTKVAELDKGQGFNAATGEYGDLVKAGVIDPVKVTRSALENAASIASLLLTTETLVVEKPAEEEPEAGHGHGHSH
>NZ_CP016824.1|WP_008413971.1|2657894_2658707_+|SDR-family-oxidoreductase
MTTALITGSTAGIGAAFARRLAASGTDGSGADRGHGAGHHLVLVARDRERLRRQATELHDRHGVEVEVLPADLSTDEGIGAVEARLADRTHPVDLLVNNAGFGNKGAYLEVPLADELKMLKVHCEAVLRLTTAATASMRERGRGGVVNVASVAAFVPRGTYGASKAWVVQFTQGAAHDLAGSGVRLMALCPGFVRTEFHQRAKMGTDNIPGWMWLDADKLVAAALADLARGRTVSIPDPRYKALMGLVKLTPRALLTGMTSRTGRKYGPQ
>NZ_CP016824.1|WP_003948570.1|2656858_2657755_-|LysR-family-transcriptional-regulator
MIEARHLRVLRAVAATGSFSAAARELGCTQPAVSQQMKALESSAGTPLLIRTGREMRLTQAGEALTRHAAGILAGLTAAEEEVAAIAGLRAGRVRLVSFPSGSSSLVPAALAALRAAHPGTRVSLEEAEPPRSAELLRAGDCDIALAFRYAGATAPDEWDDLVVRPLLADRLVGLVPEGHRLADAASAGIGELAADPWIAGCPRCRRQLVEVCETEGFTPRIDFATDDYPAVLGLVAAGLGVAVLPALALESLRPKGVRTIAVEPAVEREIVALTLPDLAQVPAVAATLDHLAATAGR
>NZ_CP016824.1|WP_067412719.1|2656350_2656695_+|WhiB-family-transcriptional-regulator
MADFSRLPGPNADLWDWQLLAACRGVDSSLFFHPEGERGAARSARETSAKEVCMRCPVRAECAAHALAVREPYGVWGGLTEDEREELMGRARTRLTPAGRAPAPGPTPPGPGLP
>NZ_CP016824.1|WP_003948568.1|2655293_2655905_-|response-regulator-transcription-factor
MTSVLVCDDSPLAREALRRAVATVPGVERVTTAANGEEVLRRWGADRSDLILMDVRMPGLGGVETVRRLLSADPGARIIMLTVAEDLDGVALAVAAGARGYLHKDASRAELRATVTQALADPTWRLAPRRLRSAEMGAAPTLTAREIQVLEGMSHGRSNAEIGRELFLSEDTVKTHARRLFKKLGASDRAHAVALGFRWGLVR
>NZ_CP016824.1|WP_003948567.1|2654465_2655041_-|sigma-70-family-RNA-polymerase-sigma-factor
MRDDETTAIGGLVHRAVEGDEQATHDLLAHVHPLALRYCRTRLSRLPGDARHFVEDLAQEVCVAVLLALPRYKDTGRPFEAFVFAIAGHKVADLQRAAMRHPGSTAVPSDEMPERPDDSLGPEERALLSSDAAWAKQLLANLPQNQRELLLLRIAVGLTAEETGQMLGMSPGAVRVAQHRALSRLRALAEQ
>NZ_CP016824.1|WP_003948566.1|2652795_2654304_-|IMP-dehydrogenase
MTANVDGVPEKFATLGLTYDDVLLLPGASDMAPDQIDTTSRLSKNVKVNVPLLSAAMDKVTESRMAIAMARQGGAGVLHRNLSIEDQANQVDLVKRSESGMVTDPITVHPDATLGEADAICAKFRISGVPVTDGSGRLLGIVTNRDMAFESDRTRQVREVMTPMPLVTGKVGISGVDAMELLRRHKIEKLPLVDDEGVLKGLITVKDFVKAEKYPNAAKDSEGRLLVGAAVGVAGDAFERAQALIGAGVDFIVVDTAHGHSRLVGDMVAKIKSNSSGVDVIGGNIATRDGAQMLIDSGADGVKVGVGPGSICTTRVVAGIGVPQVTAIYEASLAAQAAGVPVIGDGGLQYSGDIAKALVAGADTVMLGSLLAGCEESPGELLFINGKQFKSYRGMGSLGAMQTRGDRKSFSKDRYFQEGVASDEKLVPEGIEGQVPYRGPLAQVVHQLVGGLRQSMFYVGGATVPELQRNGRFVRITSAGLKESHPHDIQMTVEAPNYAAKR
>NZ_CP016824.1|WP_003948565.1|2651565_2652693_-|GuaB3-family-IMP-dehydrogenase-related-protein
MTEIEIGRGKRGRRAYAFDDIAVVPSRRTRDPKEVSIAWQIDAYRFELPFLAAPMDSIVSPETAIRVGEFGGLGVLNLEGLWTRYEDPQPLLDEIAEELDEERATRRLQEIYDAPIQEELIGRRIKEVRDAGVITAAALSPQRTAQFSKAVVDAGVDIFVIRGTTVSAEHVSGAAEPLNLKQFIYELDVPVIVGGCATYTAALHLMRTGAAGVLVGFGGGAAHTTRNVLGIQVPMATAVADVAAARRDYLDESGGRYVHVIADGGVGWSGDLPKAIACGADAVMMGSPLARATDAPGKGHHWGMEAVHEDVPRGKLVDLGMVGTTEEILTGPSRTPDGSMNMFGALRRSMATTGYSELKEFQRVEVTVADSHHKR
>NZ_CP016824.1|WP_003948564.1|2650208_2651474_+|nucleotide-sugar-dehydrogenase
MPADLAVIGLGSHGLPLAQAAVGAGVDTIGYDPDRARDLASGRLPGTGAEGALTAADVRRMLSGGFRPTADPRELGRVRTAVICAPAPAGPSGGVDLGPLAEAARALAARLRPHTTVILESPAGPGTTEEFLRPLLESGSGLTAGRDFHLAYSPGRTDPGNRTHGYAATPKVIGGLTPACTESAAAFYGRLTDKVVRARGPREAETVHVLETNYRHVNLALVNEMAVLCHDLGVDLWDVIRCAETKPFGFQAFRPGPGAGGHGLPLDPSCLPHADATPGNGLRMVSLARDINARMPQYVIQRATQLLNEHGKSARAARVLLLGVTYKPDVADQQGAPAQEIALRLTERGASVSYHDPYVPHWSPAGRPVPRADSLYEAAAEADLTILLQNHRTYDLQGLAVKAQLLLDTRGTTPAGAAHRL
>NZ_CP016824.1|WP_067412722.1|2661715_2662654_-|polysaccharide-deacetylase-family-protein
MGQVRQNEQSGGRRLHPGGLLRRTRAARLVAAGLTAAALLSGCALGTENGSGGPGTTGQAGPAPETKAQRLAKKQAAIAAATRRWGLAQVPLTAPALPDAKPTLSTRDGFEVEGQENLPHVFTTVPVKERVVFLTIDDGAEKDPEFLRMMKELDIPYSAFLSDYLVSEDYDYFRAMQKQGTALHNHTLDHPYLPGLSYEEQRHQICGMQDIIEKQYGKRPRLFRPPYGNYNQDTLKAAKSCGIEAVPLWNAEAFIDRVDYREWDRDLHPGDIVLTHFRGTGQWDGTMVDMVRQAMKVITSKGYAVARLEDYI
>NZ_CP016824.1|WP_067412725.1|2662756_2663965_+|class-I-SAM-dependent-methyltransferase
MTDLDSFTALLTPEGRALLDAVAGHDPADELATATRLRRDHPAPLVSAALGQARLRQRAAVKFGADAARMFFTPHGVEQATRTEVAAHRAARIAALGVRSVADLCCGIGGDAVALARAGVRVLAVDRDPVTAAVARANAEALGLAELIEVREAEVAEVEVGGYDAVFVDPARRGGRGGRVFDPEAYSPPLSWAVEAALRAPVAALKIAPGVPHEAIPPQAEAEWISYGGDVKEAVLWFGGAGAPGGVRPVPGSVRATLLPAGEQLWSPEPPPDVPAGPVGRYLYEPDGAVIRAHQVAEVAERVGGHLVDETIAYVTSDSLRPTPFAAAYEITDVLPFNLKRLKALLREREVGVLTVKKRGSAVEPEEVRRRMKLRGPNAATVFLTRVAGAPTMLVGGPAPAA
>NZ_CP016824.1|WP_067412727.1|2664070_2664718_+|winged-helix-turn-helix-transcriptional-regulator
MPEQPPSRIDLTHNPAALKALTHPLRVRLLGLLRSEGPATASELAATTGETSASTSYHLRVLARHGFVSEAPARDARERRWQAAHTLTAWDNEALLDQPGAEVFLATTRRQQVDHLGRTLDRHEADLAAGRLDPAWRAAAHLDDYEVRLTPASAAELGREFAARAAELAARDAGNPEAARVVVVTAALPVADRPARDAEAPEAPDAGPAQDGETP
>NZ_CP016824.1|WP_067412730.1|2664714_2666085_+|MFS-transporter
MTAAPAPADAHVLDPETARRRYVTVSALFWFPIGLYVPSLVLILGERGLALAAVAAVLSSQGLTVALLELPTGGLSDVLGRRAVLAAGGVLSFAGLLLLALGTVPWVLITGIVLMGASRALASGPAEAWYVDMAQAHSGPEAELRTGLSRGSSAMGASLAVATLLGGLLPWLFAGSGLAEATGGLVLPLSLPGLLSAALVLCYLAYVLLRLPEPPRAPSTLRSVLGSVPGTIASGVRLATRERVVRKVVLTTAAVGAALGAIELLTPGRAAAITGASESGAVVYAGLATAGFASSSLGARLAPLLARLTGGSGRAVLTALGGMACGLALLGLSAPGAGESASTPAVVTGVLGYVLVYLCLGAAGPNENDLLHHRVASSARATALSVQSLALQAVASLGGLVAGLLPLGPLPLLLTAAVVGAGALMWVRAVPDGPRPGHPDGADALAAPAASGEPGR
>NZ_CP016824.1|WP_003948578.1|2666115_2666595_+|hypothetical-protein
MSDSEDFDAFGDDVYQPQGEDTTDDSGIFDEEDNLMNTGLDDLRDEGYSPPEKPRAVEHTGTTAEEEREGESLDERLTEEVPDVQVPPGDGLGDTLDTDGELIDDEVGDLRAGRLVAPDEGAHEDAEKDIIAEDVGIDGAAASAEEAAVHLVDEDADDL
>NZ_CP016824.1|WP_003948579.1|2666704_2667121_-|CBS-domain-containing-protein
MADARTLMSTDVQSILAEETIDRAAQVMRDHNVGALPVKSADGALLGIVTDRDLVVRALAAGKTPDRTTLEDLVEDTPVAVTPDAHSTEVLQAMGNAQVRRVVVVEDGDLLGIISEADLAQHLADEDLAAFVRRVYQG
>NZ_CP016824.1|WP_008414818.1|2667340_2667616_-|hypothetical-protein
MTAHTLMWEARATQGRGADLLEWTRTRAAELAEATPSPLRTELFQAPQDRVLCLTWWHPDHGPDLPELPEPPAELITRAVHRWHFESVEVL
>NZ_CP016824.1|WP_067412732.1|2667612_2668749_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MADHRDEPLVLGIETSCDETGVGIVHGTTLLADAVASSVDEHARFGGVVPEVASRAHLEAMVATIERALTDAGVKARDLDGIAVTAGPGLAGALLVGVTAAKAYAYALGKPLYGVNHLASHICVDQLEHGRLPEPTMALLVSGGHSSLLLSSDITSDVRPLGATIDDAAGEAFDKIARVLQLGFPGGPVIDRLAREGDPEAIAFPRGLTGPRDAAYDFSFSGLKTAVARWIEAKRAAGEEIPVGDVAASFQEAVVDVLTRKAVRACKDEGVDHLMIGGGVAANSRLRALAEERCERAGIRLRVPRPGLCTDNGAMVAALGAEMVARNRAASDWQLSADSSLPVTETHVPGDAHLHPHPHSHAHSHDHVHETAKDNLYS
>NZ_CP016824.1|WP_107436714.1|2668741_2669263_-|ribosomal-protein-S18-alanine-N-acetyltransferase
MRWWDIDPVLALERELFPDDAWSRGMFWSELAHARGPEATHRYVAAYTGDRLVGYAGLATAGGTGDVQTIAVARDQWGSGLGSRLLTDLLEHATAFDCTEVMLEVRVDNTRAQALYARFGFEPIGFRRGYYQPGNVDALVMRLSDPSVNPAAPAPPAPDDPDPVPAQGTEHHG
>NZ_CP016824.1|WP_067412738.1|2669307_2669970_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB
MLLLALDTATPAVTVALHDGERVLASDTQVDARRHGELLLPAVDKLLTGAGLALADVTGVVVGVGPGPYTGLRVGLMTADTFGFALGVPVHGVCTLDGLAYASDLGPDAGPFVVATDARRKEVYWGLYADSRTPLSGPAVDRPADLADRVAGLPAVGAGALLYPETFADARAPEHVSAAALASVAAERLAAGEELLPPRPLYLRRPDAQVSKNYKVVTPK

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP016824_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_12

2698878-2698976

Orphan

Consensus_repeat	Method
AGCCCGTCCGGCGATTGAGGACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_12

>merge|NZ_CP016824|12|2698878-2698976|CRISPRCasFinder
AGCCCGTCCGGCGATTGAGGACATCTTTTCAACCGGCCACGCACCCGAGGAATCCCCCGGAAGCCCGGCCAAACTCAGCCCGTCCGGCGCTTGAGGACA

>NZ_CP016824|12|11|2698878-2698976|CRISPRCasFinder
AGCCCGTCCGGCGATTGAGGACA	TCTTTTCAACCGGCCACGCACCCGAGGAATCCCCCGGAAGCCCGGCCAAACTC
AGCCCGTCCGGCGCTTGAGGACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_003948609.1\|2692300_2693278_+\|type-I-pantothenate-kinase	unknown	unknown	gnl\|CDD\|235466
NZ_CP016824.1\|WP_010638819.1\|2696305_2697184_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067412780.1\|2697194_2698082_-\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NZ_CP016824.1\|WP_003948616.1\|2699057_2700080_-\|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl\|CDD\|235359
NZ_CP016824.1\|WP_003948621.1\|2701960_2702797_-\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
NZ_CP016824.1\|WP_008407256.1\|2695004_2695508_-\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NZ_CP016824.1\|WP_003948622.1\|2702942_2703599_-\|adenylate-kinase	unknown	unknown	gnl\|CDD\|234711
NZ_CP016824.1\|WP_003948620.1\|2701491_2701713_-\|translation-initiation-factor-IF-1	unknown	unknown	gnl\|CDD\|178954
NZ_CP016824.1\|WP_003948624.1\|2705146_2705602_-\|50S-ribosomal-protein-L15	unknown	unknown	gnl\|CDD\|235523
NZ_CP016824.1\|WP_067412777.1\|2691878_2692202_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003948617.1\|2700241_2700646_-\|30S-ribosomal-protein-S11	unknown	unknown	gnl\|CDD\|180007
NZ_CP016824.1\|WP_003948625.1\|2705603_2705786_-\|50S-ribosomal-protein-L30	unknown	unknown	gnl\|CDD\|180163
NZ_CP016824.1\|WP_067412782.1\|2703598_2704912_-\|preprotein-translocase-subunit-SecY	unknown	unknown	gnl\|CDD\|236412
NZ_CP016824.1\|WP_067412771.1\|2689246_2691148_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP016824.1\|WP_003948612.1\|2695551_2695995_-\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NZ_CP016824.1\|WP_003948619.1\|2701313_2701427_-\|50S-ribosomal-protein-L36	unknown	unknown	gnl\|CDD\|179039
NZ_CP016824.1\|WP_008407258.1\|2693357_2694719_-\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237672
NZ_CP016824.1\|WP_003948615.1\|2698170_2698671_-\|50S-ribosomal-protein-L17	unknown	unknown	gnl\|CDD\|235522
NZ_CP016824.1\|WP_003948618.1\|2700711_2701092_-\|30S-ribosomal-protein-S13	unknown	unknown	gnl\|CDD\|235358
NZ_CP016824.1\|WP_067412774.1\|2691292_2691853_-\|molybdenum-cofactor-biosysynthesis-protein	unknown	unknown	gnl\|CDD\|225167

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_003948609.1\|2692300_2693278_+\|type-I-pantothenate-kinase	gnl\|CDD\|235466	PRK05439, PRK05439, pantothenate kinase; Provisional.	0
NZ_CP016824.1\|WP_067412780.1\|2697194_2698082_-\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	2.00666e-106
NZ_CP016824.1\|WP_003948616.1\|2699057_2700080_-\|DNA-directed-RNA-polymerase-subunit-alpha	gnl\|CDD\|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	0
NZ_CP016824.1\|WP_003948621.1\|2701960_2702797_-\|type-I-methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	3.4816e-122
NZ_CP016824.1\|WP_008407256.1\|2695004_2695508_-\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	1.29069e-75
NZ_CP016824.1\|WP_003948622.1\|2702942_2703599_-\|adenylate-kinase	gnl\|CDD\|234711	PRK00279, adk, adenylate kinase; Reviewed.	1.09724e-136
NZ_CP016824.1\|WP_003948625.1\|2705603_2705786_-\|50S-ribosomal-protein-L30	gnl\|CDD\|180163	PRK05611, rpmD, 50S ribosomal protein L30; Reviewed.	1.41718e-25
NZ_CP016824.1\|WP_003948624.1\|2705146_2705602_-\|50S-ribosomal-protein-L15	gnl\|CDD\|235523	PRK05592, rplO, 50S ribosomal protein L15; Reviewed.	2.72449e-66
NZ_CP016824.1\|WP_003948620.1\|2701491_2701713_-\|translation-initiation-factor-IF-1	gnl\|CDD\|178954	PRK00276, infA, translation initiation factor IF-1; Validated.	1.40523e-47
NZ_CP016824.1\|WP_003948617.1\|2700241_2700646_-\|30S-ribosomal-protein-S11	gnl\|CDD\|180007	PRK05309, PRK05309, 30S ribosomal protein S11; Validated.	1.10697e-87
NZ_CP016824.1\|WP_067412782.1\|2703598_2704912_-\|preprotein-translocase-subunit-SecY	gnl\|CDD\|236412	PRK09204, secY, preprotein translocase subunit SecY; Reviewed.	0
NZ_CP016824.1\|WP_067412771.1\|2689246_2691148_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP016824.1\|WP_003948612.1\|2695551_2695995_-\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	1.07704e-101
NZ_CP016824.1\|WP_003948619.1\|2701313_2701427_-\|50S-ribosomal-protein-L36	gnl\|CDD\|179039	PRK00465, rpmJ, 50S ribosomal protein L36; Reviewed.	1.17108e-12
NZ_CP016824.1\|WP_008407258.1\|2693357_2694719_-\|phosphoglucosamine-mutase	gnl\|CDD\|237672	PRK14318, glmM, phosphoglucosamine mutase; Provisional.	0
NZ_CP016824.1\|WP_003948615.1\|2698170_2698671_-\|50S-ribosomal-protein-L17	gnl\|CDD\|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	3.05388e-64
NZ_CP016824.1\|WP_003948618.1\|2700711_2701092_-\|30S-ribosomal-protein-S13	gnl\|CDD\|235358	PRK05179, rpsM, 30S ribosomal protein S13; Validated.	4.74824e-76
NZ_CP016824.1\|WP_067412774.1\|2691292_2691853_-\|molybdenum-cofactor-biosysynthesis-protein	gnl\|CDD\|225167	COG2258, COG2258, Uncharacterized protein conserved in bacteria [Function unknown].	2.74122e-22

>NZ_CP016824.1|WP_003948615.1|2698170_2698671_-|50S-ribosomal-protein-L17
MPKPTKGARLGGSAAHERLMLANLARSLFEHGRIKTTEAKARRLRPYAERLVTKAKKGDLHNRRQVLQVITDKSVVHTLFTEIGPRYENRPGGYTRITKVGNRRGDNAPMAVIELVEALTVAQEATGEAEAATKRAVKEDAAGKDQAATEAPEAAAEAKDDEAKDA
>NZ_CP016824.1|WP_067412780.1|2697194_2698082_-|tRNA-pseudouridine(38-40)-synthase-TruA
MSEQVEYTERRDGPEDGHVRVRLDLSYDGRDFSGWAKQAAGRRTVQGEIEDALRTVTRSGERTYELTVAGRTDSGVHARGQVAHVDLPAAVWEEHREKLLRRLAGRLPHDVRIWRVAEAPAGFDARFSAVWRRYAYRVTDHPGGVDPLLRGHVLWHDWTLDVEAMNAASAALLGEHDFAAYCKRREGATTIRTLQELSWERDRDGIVTATVRADAFCHNMVRSLVGALLFVGDGHRPVEWPGKVLAAGVRDSAVHVVRPHGLTLEEVGYPADELLAARNREARNKRTLPNTACCG
>NZ_CP016824.1|WP_010638819.1|2696305_2697184_+|hypothetical-protein
MSYGQGGPPWGQGDRGPQGQQPYGQQRPATPDWEALASASEARGRKRRWTLIGGGAVATVAVAALVATLVVRANSDDPKASDPIGGVSSSSALPEDTTAPAPSFSEVAPPPPPDPKDFVSSAEKDKAPLTALSLYPGRKLTVGDRVYAKGALHRTTKCASGTQGALGQVLTKNGCEQLIRATYRRDGVAVTVGVATFKTADVAARVKEETSGNVASLAGEGVPTFCRTTVCRSTANAYGRYVYFTVGGFTNGDNVTKQDRAVFTTGDDVAEFTLRQIHRRGVAQASQAAAAQ
>NZ_CP016824.1|WP_003948612.1|2695551_2695995_-|50S-ribosomal-protein-L13
MRTYSPKPGDVTRQWHVIDARDVVLGRLATTAATLLRGKHKPIYAPHVDTGDFVVIINADKIHLSGNKRTQKMAYRHSGYPGGLRSVRYDELMDKNPEKAVEKAVKGMLPKNTLGRQMLSKLKVYAGEQHPHAAQQPVPFEITQVAQ
>NZ_CP016824.1|WP_008407256.1|2695004_2695508_-|30S-ribosomal-protein-S9
MAETTAELPLDDIEQYTTESETPEGDYTSESLASGFGEPQPAAGLGRRKNAIARVRIVPGTGKWKINGRTLEDYFPNKVHQQEVNEPFKVLELEGRYDVIARISGGGVSGQAGALRLGVARALNEADVDNNRGALKKAGFLTRDDRAVERKKAGLKKARKAPQYSKR
>NZ_CP016824.1|WP_008407258.1|2693357_2694719_-|phosphoglucosamine-mutase
MGRLFGTDGVRGVANADLTAELALGLSVAAAHVLAEAGTASTGHRQVAVVGRDPRASGEFLEAAVVAGLASAGVDVLRVGVLPTPAVAYLTGALGADLGVMLSASHNAMPDNGIKFFARGGHKLADELEDRIEALYEEHRTGAAWERPTGAGVGRVRDYDEGFDQYVAHLIGVLPNRLDGLKIVLDEAHGAAARVSPEAFARAGAEVVTIGADPDGLNINDGCGSTHMELLRAAVVEHGAHLGIAHDGDADRCLAVDAEGREIDGDQILAVLALSMREHGGLRSQTVVATVMSNLGFKLALEREGISLVQTAVGDRYVLEEMKEHGYALGGEQSGHVIILDHATTGDGTLTGLMLAARVAETGRPLAELAGVMERLPQVLVNVPDVDRSRVTTSAELASAVAQAEQELGATGRVLLRPSGTEPLVRVMVEAADIEQAGAIAGRLADVVKSALG
>NZ_CP016824.1|WP_003948609.1|2692300_2693278_+|type-I-pantothenate-kinase
MITPESRSAHRKPEATPYVDLTREQWSALREKTPLPLTADEVEKLRGLGDVIDLDEVRDIYLPLSRLLNLYVGATDGLRSALNTFLGEKGEQSGTPFVIGVAGSVAVGKSTVARLLQALLARWPEHPRVELVTTDGFLLPMAELRARGLTARKGFPESYDRRALTRFVADIKAGKDQVTAPVYSHLVYDIVPDRRLTVNRPDILIVEGLNVLQPALPGKDGRTRVGLADHFDFSVYVDARPEDIERWYLNRFRKLRATAFQDPSSYFRRYTQVSEEEALDYARSTWRTINLPNLVENVAPTRGRANLVIRKGPDHKVRKLSLRKL
>NZ_CP016824.1|WP_067412777.1|2691878_2692202_-|hypothetical-protein
MSTGAVGGAYGAGGVFWFAVERAEAAPAGRRGPLAAWRRWRGGAQARRDRALLARSAVVAELARELPDEDFGGYLEDAVALYRDGSKPYAEEAEYLDLVADALDRVG
>NZ_CP016824.1|WP_067412774.1|2691292_2691853_-|molybdenum-cofactor-biosysynthesis-protein
MSVRDGATGRITAVSSDSTHRFSKPNRAGITLLAGLGVAGDAHAGVTVQHRSRVARDPSRPNLRQVHLLAGELLAELAAAGHPVAPGELGENVTTYGVDLLALPAGALLRLGPEAVVEVTGLRNPCLQIDAFQEGLLRRVVGRAPDGSVVRRAGIMGVVRTGGTLRPGDPVGVELPAGEHRPLEPV
>NZ_CP016824.1|WP_067412771.1|2689246_2691148_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYVGAQSALDVVLAGLRRLEYRGYDSAGVAVLAGDQVACVKKAGKLSQLEKALVDDPLPGSDATGDGHGGATGIGHTRWATHGGPTDTNAHPHLDASGRCAVVHNGIIENFAALREELAARGADVRSQTDSEVAAHLLAEEYAALEGTGQEGGPRLAGALRAVCRRLEGAFTLVALHADVPDVIVGARRNSPLVVGCGEGEAFLASDVSAFIDHTRTAMELGQDQVVEVHPDRAVVTGFDGSPADARTYRVDWDASAAEKDGYDSFMLKEIAEQPKAVADTLLGRLDPALGTLTLGAELGLDPAVLREAEKVVVIACGTAHHAGLVARLAVERWAQLPCEVELASEFRYRDPIVGPRTLVVAVSQSGETADTLMALRHAREQGATVLAVCNTNGSTIPRESDAVLYTHAGPEVAVASTKAFLTQLVACLLLALHLGEVRRGPSEELREAARALSRAPEDVAAVLATMEPVRELARGLAHKETVLFLGRHSGHPVALEGALKLKELAYFHAEGFAAGGLKHGPIALIEPDLPVIVVVPSPVTAALLHGKIVSNIQEIRARGARTIVLAEAGDEAVAPYADHLIRLPAVPPLIQPLVAAVPLQVFACELATARGNDVDQPRNLAKSVTVE
>NZ_CP016824.1|WP_003948616.1|2699057_2700080_-|DNA-directed-RNA-polymerase-subunit-alpha
MLIAQRPSLTEEVVDEFRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTDLILNIKQLVVSSEHDEPVVMYLRKQGPGLVTAADIAPPAGVEVHNPDLVLATLNAKGKLEMELTVERGRGYVSAVQNKQAGQEIGRVPVDSIYSPVLKVTYKVEATRVEQRTDFDKLIVDVETKQAMRPRDAMASAGKTLVELFGLARELNVDAEGIDMGPSPTDAALAADLALPIEELELTVRSYNCLKREGIHSVGELVARSEADLLDIRNFGAKSIDEVKAKLAGMSLALKDSPPGFDPTAAADAFGADDDADAGFVETEQY
>NZ_CP016824.1|WP_003948617.1|2700241_2700646_-|30S-ribosomal-protein-S11
MPPKGRQGAAKKVRRKEKKNVAHGHAHIKSTFNNTIVSITDPTGNVISWASAGHVGFKGSRKSTPFAAQMAAESAARRAQEHGMRKVDVFVKGPGSGRETAIRSLQATGLEVGSIQDVTPTPHNGCRPPKRRRV
>NZ_CP016824.1|WP_003948618.1|2700711_2701092_-|30S-ribosomal-protein-S13
MARVSGVDIPREKRVEVALTYVFGIGRTLSQQTLEATGVDPNARVRDLSEEDLVKIREYVDNNIKTEGDLRREIQADIRRKVEIGCYQGLRHRRGLPVHGQRTSTNARTRKGPRRAIAGKKKPGKK
>NZ_CP016824.1|WP_003948619.1|2701313_2701427_-|50S-ribosomal-protein-L36
MKVKPSVKKICDKCRVIRRHGRVMIICDNPRHKQRQG
>NZ_CP016824.1|WP_003948620.1|2701491_2701713_-|translation-initiation-factor-IF-1
MAKKQGAIEIEGTVVESLPNAMFKVELQNGHQVLAHISGKMRMHYIRILPDDRVVVELSPYDLTRGRIVYRYK
>NZ_CP016824.1|WP_003948621.1|2701960_2702797_-|type-I-methionyl-aminopeptidase
MVQIKSPEQIAKMREAGLVVAAIHRATREAAVPGATTQDLDQVARKVLEEHGARSNFLGYGGFPATICTSVNEVVVHGIPDEKTVLADGDIISIDCGAIVDGWHGDAAYTAFVGSGHAPELVELSRVTEESMWAGIAAMKQGNRLVDISRAIETYIRRQPKPGGGKYGIVEDYGGHGIGTEMHMDPHLLNYVERRRGKGPKLVPGFCLAIEPMVSLGTPKTEVLEDDWTVITTDGTWSSHWEHSVALTEQGPLVLTAEDGGKAKLAEFGITTAPDPAA
>NZ_CP016824.1|WP_003948622.1|2702942_2703599_-|adenylate-kinase
MRIVLVGPPGAGKGTQAAFLAKNLSIPHISTGDLFRANISQGTELGKQAKSYMDAGNLVPDEVTIGMAEDRMAQPDAENGFLLDGFPRNVSQAKALDESLKAQGVALDAVLDLEVPEDEVVKRIAGRRICRNDSSHVFHVEYSKPETEGVCDVCGGELYQRADDKEETVRKRLEVYHNETEPIIDHYKAQGLVVTISALGKVDEVTARAMAALGADQK
>NZ_CP016824.1|WP_067412782.1|2703598_2704912_-|preprotein-translocase-subunit-SecY
MLTAFARAFKTPDLRKKLLFTLGIIVLYRIGAHVPIPGVSYQNVQICMDQANATQGLFGLVNMFSGGALLQITIFALGIMPYITASIILQLLTVVIPRLEALKKEGSSGQAKITQYTRYLTVALAVLQGTGLVATARSGSLFQGCPVAGEIVPDQSIFVTAVMILTMTAGTALVMWLGELITDRGIGNGMSILMFISIAASFPASLWAIKEQGDLAGGWIEFGTVILVGLAMVGLVVFVEQAQRRIPVQYAKRMIGRRSYGGTSTYIPLKVNQAGVIPVIFASSLLYIPALIVQFSNSQAGWAQWINNNLADTGATAHVILYFFLIVFFAFFYVAISFTPEEVADNMKKYGGFIPGIRAGRPTAEYLSYVLNRITWPGSLYLGLIALVPTMALAGFGANQNFPFGGTSILIIVGVGLETVKQIESQLQQRNYEGFLR
>NZ_CP016824.1|WP_003948624.1|2705146_2705602_-|50S-ribosomal-protein-L15
MAEQNPLKVHNLRPAPGAKTAKTRVGRGEASKGKTAGRGTKGTKARYQVPERFEGGQMPLHMRLPKLKGFKNPFKTEFQVVNLDKLAELYPEGGEVTVEGLVAKGAVRKNSLVKVLGQGDVSVALQVTVDAVSGSAKEKITAAGGTVTELV
>NZ_CP016824.1|WP_003948625.1|2705603_2705786_-|50S-ribosomal-protein-L30
MPQLKITQKKSYIGSKQNHRDTLRSLGLKKVNDVVVKEDRPEFRGMVHTVRHLVTVEEVD

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP016824_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_13

2809590-2809677

Orphan

Consensus_repeat	Method
TGGCCTCAAGCGCCGGCCGGGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_13

>merge|NZ_CP016824|13|2809590-2809677|CRISPRCasFinder
TGGCCTCAAGCGCCGGCCGGGCTGGATGTGGCCGGGCTTCGCGGGCCCGGCCGCGCGTTCAAGATGGCCTCAAGCGCTGGCCGGGCTG

>NZ_CP016824|13|12|2809590-2809677|CRISPRCasFinder
TGGCCTCAAGCGCCGGCCGGGCTG	GATGTGGCCGGGCTTCGCGGGCCCGGCCGCGCGTTCAAGA
TGGCCTCAAGCGCTGGCCGGGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_003948727.1\|2817244_2817544_-\|NADH-quinone-oxidoreductase-subunit-NuoK	unknown	unknown	gnl\|CDD\|180218
NZ_CP016824.1\|WP_067412914.1\|2808301_2809522_+\|fumarylacetoacetase	unknown	unknown	gnl\|CDD\|215461
NZ_CP016824.1\|WP_067412923.1\|2813727_2815329_-\|NADH-quinone-oxidoreductase-subunit-M	unknown	unknown	gnl\|CDD\|235622
NZ_CP016824.1\|WP_067412935.1\|2820502_2823031_-\|NADH-quinone-oxidoreductase-subunit-G	unknown	unknown	gnl\|CDD\|236118
NZ_CP016824.1\|WP_067412920.1\|2812081_2813731_-\|NADH-quinone-oxidoreductase-subunit-NuoN	unknown	unknown	gnl\|CDD\|235603
NZ_CP016824.1\|WP_067412926.1\|2815334_2817230_-\|NADH-quinone-oxidoreductase-subunit-L	unknown	unknown	gnl\|CDD\|235836
NZ_CP016824.1\|WP_008408177.1\|2818352_2819051_-\|NADH-quinone-oxidoreductase-subunit-NuoI	unknown	unknown	gnl\|CDD\|235637
NZ_CP016824.1\|WP_067412932.1\|2819043_2820420_-\|NADH-quinone-oxidoreductase-subunit-NuoH	unknown	unknown	gnl\|CDD\|235692
NZ_CP016824.1\|WP_067412929.1\|2817540_2818356_-\|NADH-quinone-oxidoreductase-subunit-J	unknown	unknown	gnl\|CDD\|235844
NZ_CP016824.1\|WP_079165330.1\|2806407_2807451_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|369792
NZ_CP016824.1\|WP_067412909.1\|2797315_2798608_-\|DUF2092-domain-containing-protein	unknown	unknown	gnl\|CDD\|225390
NZ_CP016824.1\|WP_008408163.1\|2805933_2806383_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_010638944.1\|2807879_2808086_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003948714.1\|2798842_2799853_-\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|173833
NZ_CP016824.1\|WP_067412912.1\|2804803_2805652_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238979
NZ_CP016824.1\|WP_067412917.1\|2809687_2811769_-\|DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|273594
NZ_CP016824.1\|WP_018893921.1\|2800280_2801828_+\|peptide-MFS-transporter	unknown	unknown	gnl\|CDD\|225646
NZ_CP016824.1\|WP_003948732.1\|2823027_2824377_-\|NADH-quinone-oxidoreductase-subunit-NuoF	unknown	unknown	gnl\|CDD\|131014
NZ_CP016824.1\|WP_003948717.1\|2804011_2804797_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187591
NZ_CP016824.1\|WP_079051710.1\|2801870_2803913_+\|CocE/NonD-family-hydrolase	unknown	unknown	gnl\|CDD\|225487

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_003948727.1\|2817244_2817544_-\|NADH-quinone-oxidoreductase-subunit-NuoK	gnl\|CDD\|180218	PRK05715, PRK05715, NADH-quinone oxidoreductase subunit NuoK.	4.68669e-43
NZ_CP016824.1\|WP_067412914.1\|2808301_2809522_+\|fumarylacetoacetase	gnl\|CDD\|215461	PLN02856, PLN02856, fumarylacetoacetase.	1.12857e-153
NZ_CP016824.1\|WP_067412923.1\|2813727_2815329_-\|NADH-quinone-oxidoreductase-subunit-M	gnl\|CDD\|235622	PRK05846, PRK05846, NADH:ubiquinone oxidoreductase subunit M; Reviewed.	0
NZ_CP016824.1\|WP_067412935.1\|2820502_2823031_-\|NADH-quinone-oxidoreductase-subunit-G	gnl\|CDD\|236118	PRK07860, PRK07860, NADH dehydrogenase subunit G; Validated.	0
NZ_CP016824.1\|WP_067412920.1\|2812081_2813731_-\|NADH-quinone-oxidoreductase-subunit-NuoN	gnl\|CDD\|235603	PRK05777, PRK05777, NADH-quinone oxidoreductase subunit NuoN.	2.7715e-178
NZ_CP016824.1\|WP_067412926.1\|2815334_2817230_-\|NADH-quinone-oxidoreductase-subunit-L	gnl\|CDD\|235836	PRK06590, PRK06590, NADH:ubiquinone oxidoreductase subunit L; Reviewed.	0
NZ_CP016824.1\|WP_008408177.1\|2818352_2819051_-\|NADH-quinone-oxidoreductase-subunit-NuoI	gnl\|CDD\|235637	PRK05888, PRK05888, NADH-quinone oxidoreductase subunit NuoI.	1.74531e-82
NZ_CP016824.1\|WP_067412932.1\|2819043_2820420_-\|NADH-quinone-oxidoreductase-subunit-NuoH	gnl\|CDD\|235692	PRK06076, PRK06076, NADH-quinone oxidoreductase subunit NuoH.	2.92021e-164
NZ_CP016824.1\|WP_067412929.1\|2817540_2818356_-\|NADH-quinone-oxidoreductase-subunit-J	gnl\|CDD\|235844	PRK06638, PRK06638, NADH-quinone oxidoreductase subunit J.	5.69667e-72
NZ_CP016824.1\|WP_079165330.1\|2806407_2807451_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	2.03731e-65
NZ_CP016824.1\|WP_067412909.1\|2797315_2798608_-\|DUF2092-domain-containing-protein	gnl\|CDD\|225390	COG2834, LolA, Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane].	2.00041e-08
NZ_CP016824.1\|WP_003948732.1\|2823027_2824377_-\|NADH-quinone-oxidoreductase-subunit-NuoF	gnl\|CDD\|131014	TIGR01959, NADH-quinone_oxidoreductase_subunit_F, NADH-quinone oxidoreductase, F subunit. This model describes the F chain of complexes that resemble NADH-quinone oxidoreductases. The electron acceptor is a quinone, ubiquinone, in mitochondria and most bacteria, including Escherichia coli, where the recommended gene symbol is nuoF. This family does not have any members in chloroplast or cyanobacteria, where the quinone may be plastoquinone and NADH may be replaced by NADPH, nor in Methanosarcina, where NADH is replaced by F420H2. [Energy metabolism, Electron transport].	0
NZ_CP016824.1\|WP_003948714.1\|2798842_2799853_-\|polyprenyl-synthetase-family-protein	gnl\|CDD\|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	7.19553e-87
NZ_CP016824.1\|WP_067412912.1\|2804803_2805652_-\|hypothetical-protein	gnl\|CDD\|238979	cd02021, GntK, Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.	2.51918e-05
NZ_CP016824.1\|WP_067412917.1\|2809687_2811769_-\|DNA-helicase-RecQ	gnl\|CDD\|273594	TIGR01389, recQ, ATP-dependent DNA helicase RecQ. The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP016824.1\|WP_018893921.1\|2800280_2801828_+\|peptide-MFS-transporter	gnl\|CDD\|225646	COG3104, PTR2, Dipeptide/tripeptide permease [Amino acid transport and metabolism].	6.89957e-124
NZ_CP016824.1\|WP_003948717.1\|2804011_2804797_+\|SDR-family-oxidoreductase	gnl\|CDD\|187591	cd05330, cyclohexanol_reductase_SDR_c, cyclohexanol reductases, including levodione reductase, classical (c) SDRs. Cyloclohexanol reductases,including (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) reductase of Corynebacterium aquaticum, catalyze the reversible oxidoreduction of hydroxycyclohexanone derivatives. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.22358e-132
NZ_CP016824.1\|WP_079051710.1\|2801870_2803913_+\|CocE/NonD-family-hydrolase	gnl\|CDD\|225487	COG2936, COG2936, Predicted acyl esterases [General function prediction only].	2.22339e-113

>NZ_CP016824.1|WP_067412914.1|2808301_2809522_+|fumarylacetoacetase
MPEPTPLALPEGHPFGPHNLPYGVFSPGDAPRRVGVRLGDHVLDAGALAAELGSPHAALLTGPTLNPLLAAGRPVWSQVRAALTTWVTDPAHHPAVERHAHPLAEVSLHLPFEVGDYVDFYASEHHASNVGRIFRPDAPTPLTPNWKHLPIGYHGRSGTVVVSGTDVVRPSGQRKAPADPAPVFGPSVKLDIEAEVGFVVGVGSERGRAVPLEAYRDHVFGLCLLNDWSARDIQAWEYVPLGPFLGKSFATSVSAWVTPLEALETARVVPPARDEALLPYLDDSSAEPGGYDLRISVEINGQVVSEPPFTTMYWTAAQMLAQTTVNGASLRTGDLYGSGTVSGAEAGQRGSLLELTWNGERPLELGSGERSFLEDGDEVVLRAWAPGAQGVPVGLGEVRGTVVPRT
>NZ_CP016824.1|WP_010638944.1|2807879_2808086_-|hypothetical-protein
MASSYRTNDGHTVRIGSTVWGVNGQGPFTLVEPESAPEGWVSVVSADGEDWRLHAPEDIALYYVTTRP
>NZ_CP016824.1|WP_079165330.1|2806407_2807451_-|Cof-type-HAD-IIB-family-hydrolase
MPGWRMPGAYLRIVGIMALLPARPSPAPPEAPPHPPHAHTPVLTQPGPAQAEAQPVLAQAEAEADSAPWRAPTRERPRPAGGRRTYGLVATDLDGTLLRAGDRVSARTRAALELARGAGARHIVVTGRPVPGVRGLLAALGYEGIAVCGQGAQVYDTASGRMLSALTLDRETAATALGKIEAETGALYAAVDQDGTDGHTLIEPGYRMAHPTLPARPVPHRDALWERPIAKVLVRHPELTDDELAATARSAVDGLATVTMAGPGTVELQPLGVTKATGLARAAELLGLGPADTLAFGDMPNDVPMLQWAAHGVAMANSHPELLAVADEITTSNEEDGVARVLERVYG
>NZ_CP016824.1|WP_008408163.1|2805933_2806383_+|hypothetical-protein
MTVLGHQPPGPDEATGPPAPPPAAALEVLRPRLRTAGQQFAIGPGWRRLVLDCHHRISAEFPAYELLAVKQKYGRLSFQAFPRPWRPGERSWTPDEHARLHELLDATIARSESLCERCAAPARLRRTRRLWLTLCDACEATVGESGELG
>NZ_CP016824.1|WP_067412912.1|2804803_2805652_-|hypothetical-protein
MSQGKEPAVPGRKGPPGPAPRAVWIGGPPGAGKTTLARALAHRRGLRLYRSDTLTWEHRDRALAAGHPAATRWEALTPADRWSAPPAALLAMSLHAERGAMIADDVRALGPGPLTVVEGTPVTPDTVPDPGRAVWLMPSPELQRRRLAERGLPEGVHTLYTLLLADLAARIQAHGLAGRVVTVTPDATPADTRTAAEALLAGPLAEGPTATSPDERRTLRRAENEAVATQYRTYLARPWTTGDPDTVPVTFSCECADPECTAQLTRPLGTFPPAGGGALRCH
>NZ_CP016824.1|WP_003948717.1|2804011_2804797_+|SDR-family-oxidoreductase
MAGAFDGRTVLITGGGAGLGRAAAVRVAREGARVALVDVSEEGLTASASAVAEAAPGTEVVRIVADVAEEDAVRSYVDETMSAFGRIDGFFNNAGIEGRQNLTQEYGAEEFDRVVAINLRGVFLGLKYVLPVLKDQGHGSVVNTASVGGLRGVGNQSGYAASKHGVVGLTRNSGVEYGKFNVTVNAIAPGAIMTDMVEASLKQMDPDNWEEAGRQFVSVNPMRRFGRPEEVAHLVAFLLSGAAGFINASVVPIDGGQSYQY
>NZ_CP016824.1|WP_079051710.1|2801870_2803913_+|CocE/NonD-family-hydrolase
MSLHIATGLPYRTIREDVRIPLPTGRLGADGSEITHLYARIWRPVTDEPVPALLEYLPYRLSDWTAPRDQQRHPWYAGHGYASVRVDVRGHGNSEGLPGDEYDATELADGVAVIHWLADQPWCDGKVGMFGISWGGFNSLQIAALAPEPLKAIVTVCSADDRYDNDVHYMGGSVLAVDMHAWASTMLAFVSRPPDPEFVGPAWRDMWLKRLEAVDPFIHTWLDHQTRDAYWRHGSVSEDYSAIKAKVLAVGGWHDPYRDTVLRLVRHLPDDQVRGLIGPWSHQYPDRGLPPGPAIGFLQETLRWWDQHLKGEDSGVMNEPKLRSWISESHPPATVYPELEGHWVGDPAWPSPYVTPVEYAFQGGPVLVRSPQHTGLAAGRFFPFGNDADLPPDQREEDANSAAFEFAVDERLQILGRPRVRLRLTSPAPRGQVIARLCDVAPDGSSTLVTRGVLNLSSRYGRDTVAPWKPGDTEDVTFELNGIGHAFPPGHRIRLAVSSAYWPWIWPQPGSEEGFTLDPAGSGVELPVRGAGDRALDATIAFAEPEQAEPLAVVYPAPENPADQRPERLVVHDVAAGSWRLDVDPRYGGTRIYPDGLEFHEDALEQYTITDNDPLSAATRSSWTVRLRRPELAWDAEVRTRSEITCDAGDFLTHNELTCSEGGEVIFQRTWERRIPRTAG
>NZ_CP016824.1|WP_018893921.1|2800280_2801828_+|peptide-MFS-transporter
MPSSNPADDEPTKRPPAVADDEPPPEGAPPPQDDTAFFGQPRGLATLSGLEVWERFSFLGMQAILVLFFADTVAGGGMGMDPGTAASVSAAYGTMVYLVSVAGGWLADRMLGSYRAVLWGGILIALGHYSMAVPTDAMTWTGLGLISAGTGLLKPNVATMVGKLYRTDDDRRDAGFALYYMGINIGAFLGPLITGWLGEHQGWHWGFSAAAVGMTLGLVQYVLGRNHLAGRKHAAEFALPPTAMRRAVLLIAGGLVAVAVIAGLLSLAGWLTLSRFVDALTLISVLAPIAYFWVMFKSPRVTAAERGRLRPYIVLFLASVVFNFILFQAYSTMILLASTNARTEILGFTFPASWYASALGAFEVLLAPVVAAVWARMGTRQPHASNKIAFGVILGGLSFLLMVLPTSGHADDTYRMAAWWIVGSYLLLGLGDILLETSGMSATTKLAPAAFSSQTMALWFLSLAAANGIQSQVVRLYGEVSNPAYFGVNGGIAVVAGLAVIAAAPWLRRTMHPVH
>NZ_CP016824.1|WP_003948714.1|2798842_2799853_-|polyprenyl-synthetase-family-protein
MTVVGPFGLSVRDQALEADVQAGMAAVEAGLLEATKSEVSFITDAAQHLLKAGGKRLRPLLVMLAAQFGDPDAPGIVPSGVVVELTHLATLYHDDVMDEAEVRRGVPSANARWDNSVAVLTGDFLFARASHILADLGPEAVRVQAEAFERLVTGQIMETAGPRDGRDPVDHYLDVLGGKTGSLIAVAGRFGAMMSGADERVVDILTQYGERLGVAFQLADDVLDIASDSHESGKTPGTDLRESVPTLPVLLLRDRARREERPEDLALVALLDSDLTDDARHAEALAAMRAHPALEQARRETVRYAEEARAALTPLRECSAKAALVELCDAVVHRAG
>NZ_CP016824.1|WP_067412909.1|2797315_2798608_-|DUF2092-domain-containing-protein
MAPNDSATTTPAPDAKRRPGRLAARYGVPVAVIGVAAATIGLVPALAAGGDPDLPEVTAQELVEKIAASETDQFSGTVKVSVDLGLPSFGGLDLSELAGSLGGEGKDGKGGSTATPEEKLTSLASGTHTLRVAGDGPDRQKLTFVDGADEYSLIRDGDQAWAYDGSTGEALHTKDAGAKGDRPADDHVSDMSPKELATKALDAADETTRVTVDGTTTVAGRDAYRLALTPKDSGSTVKAVRIAVDAETGTPLKFTVAPSDGGKAIVDAGFSKIDFARPSTGTFAPPKDAKITESKELAPGDATPGKDAKGDAHSKAPKDTEAAKGAEEALNSLPAPLAGLASAEGTEIHGKGWASVAELTFPKGQGLPAAGSDSDAPGGLSLDSLGKKVKGDFGTGTLFSTRIVNALVTEDGRAFVGAVTPEKLVEVAGK
>NZ_CP016824.1|WP_067412917.1|2809687_2811769_-|DNA-helicase-RecQ
MASTSTDGGTPAYDGPEGFPDDLFDGGPPEEDPFGDEPFPDEAFGEDGAREELSGAFPEGSGEAPVHDRRDALATLRSVFGYDAFRGDQEAVIDHLVGGGDAVVLMPTGGGKSLCYQIPAMVRPGTGVVVSPLIALMQDQVDALRAAGVRAGFINSTQDFEERRLTEAEFLAGELDLLYLAPERLRVDATLELLSRGKISLFAIDEAHCVAQWGHDFRPDYLALSVLGERWPDVPRVALTATATDATHQEITRRLALPDAKHFVASFDRPNIQYRIVPKNDPKKQLLTFLKEEHPGDAGIVYCLSRNSVERTADFLRDHGVEAVPYHAGLDARTRATNQSRFLREDGLVVVATIAFGMGIDKPDVRFVAHLDLPKSVEGYYQETGRAGRDGRPSTAWMAYGLQDVVQQRKLIQSGEGDEAHRRRSQSHLDAMLALCETAQCRRAQLLRYFGQEPTGENCGNCDTCLTPPETWDGTVAAQKAMSTVVRLKRERNQKFGTGQIIDILMGRKTAKVIQFDHDQLSVFGVGQELSEGEWRGAVRQLLAQGLLAVEGEYGTLVLTDEAGEVLGGRREVRFRKEPKKAPSSRGSRSGSAAGSGGRKSKAVIDLPEESLPVFEALRAWRAAQAREQGVPAYVIFHDATLREITAARPTTLDALGQIGGIGDKKLQNYGPGVLETLAEQGIGEAPDSPAGA
>NZ_CP016824.1|WP_067412920.1|2812081_2813731_-|NADH-quinone-oxidoreductase-subunit-NuoN
MNANAVHTLWTSAAADPISKIPSPTIEYAQLAPRMIVIGAAVIGIVVEAFAPRRARYHIQLWLTVVALGAAFASVVALAVGGYATTKQTSVAMGALAVDGPALFLQGVILLSGVLAAFTFAERRLDRAHGKRVDSFVAQAGAVPGSEAEQAAVKAGFATTEVFPLMLFAVGGMIVFPAANDLLTLFIALEVFSLPLYLMCALARRRRLMSQESAVKYFLLGAFSSAFLLFGIALLYGYSGSVSYAVIADVVDGTLISNDPVLAQTMGNDALLLIGMALVLMGLLFKVGAVPFHMWTPDVYQGAPTPVTGFMAAATKVAAFGALLRLLYVVLPGMRWDWRPVMWGVAIATMVVGAIVAVTQTDVKRLLAYSSVAHAGFILAGVIAATPAGVSSVLFYLAAYSFVTIGAFAVVTLVRDAGGEATHLSKWAGLGRRSPLVAAVFAVFLLAFAGIPLTSGFSGKFAVFSAAAEGGAGALVIIGVLSSAVAAFFYVRVIVLMFFSEPRADGPTVTVPSPLTMSVIGVGVVVTVVLGVAPQYFLDLAGQASVFVR
>NZ_CP016824.1|WP_067412923.1|2813727_2815329_-|NADH-quinone-oxidoreductase-subunit-M
MSFPLLTATAALPAIGAIVTAAVPAARSRSDGDGPRGSGTAKVVALFFSVATFVLAMTVLVRFEPGGARYQLTESYDWIPAFGVRYELGVDGIGVALIALTALLIPFVILAGWRDADHLENSSRRWRPTQGFFALILMVEAMVILSFEATDVFLFYLFFEAMLIPMYFLIGGFGDRASGTDEAQAATQRSYAAVKFLLYNLAGGLIMLAAVIGLYSVAGTFSLSEIAQARADGTLEMAASTEKWLFLGFFFAFAIKAPLWPLHTWLPNAMGEATAPVAVLITAVVDKVGTFAMLRFCLGLFPEASKWATPVVLVLALVSIIYGALLAVGQRDIKRLVAYASISHFGFIILGIFAMTSQGQSGATLYMVNHGLSTAALMLVAGFLISRRGSRLIADYGGVQKVAPVLAGTFLVGSLATLSLPGLAPFVSEFLVLVGTFTRYPVIGVIATVGIVLGALYTLVLYQRTMTGPVKPSVAKMPDLKVRELAVIGPLIALLLFLGVYPKPLTELVDPAVGHTLSDVQQKDPKPDVEAAK
>NZ_CP016824.1|WP_067412926.1|2815334_2817230_-|NADH-quinone-oxidoreductase-subunit-L
MENLIALLVAAPLLGAAVLLLGGRRLDRAGHLLGTVMAAASFGLAVVLFTDMLGRAGDDRSLHQHLFSWIPVGGFQADVAFQLDQLSMTFVLLITGVGTLIHVYSIGYMEHDERRRRFFAYLNLFLAAMLLLVLADNYLLLYVGWEGVGVASYLLIGFWQHKPSAATAAKKAFLVNRVGDVGLSIAIMLMFTTFGTFAFGPVLASTGETSEGKLTAIALMLLLAACGKSAQVPLQSWLGDAMEGPTPVSALIHAATMVTAGVYLITRSGAIFNAAPDAQTVVVVVGAVTLLFGAIVGCAKDDIKKALAGSTMSQIGYMVLAAGLGPIGYVFAIMHLVTHGFFKAGLFLGAGSVMHGMNDEVDMRKYGGLRKYMPVTFVTFSLGYLAIIGFPGLSGFWSKDKIIEAAFAKGGAEGWILGAVTLLGAALTAYYMTRVMLMTFFGEKRWQPDAEGNEPHPHESPKSMTIPMIVLAFGSVFAGGLFSLGDSFIKWLEPVTAFEHGHSPLSAAVVTSATVVVLLIGVGLAWLQYGRKPVPVVAPRGSLLTRAARRDLGQDDFNHVVLVRGGEHLTRSLVYVDHTLVDGVVNGTAASVGGLSGRLRKLQTGYARTYAVSMFGGTAVLIAATLLMRAV
>NZ_CP016824.1|WP_003948727.1|2817244_2817544_-|NADH-quinone-oxidoreductase-subunit-NuoK
MNPVNYLYLAALLFTIGATGVVIRKNAIVVFMCVELMLNACNLSLVAFSRMHGNLDGQILAFFTMVVAAAEVVVGLAIIVSLFRARHSASVDDASLMKL
>NZ_CP016824.1|WP_067412929.1|2817540_2818356_-|NADH-quinone-oxidoreductase-subunit-J
MSLLAASATSTGEAVQFWILGTVAVLGALSTVLMKKAVHSALCLAATMIVLAVFYLANGAYFLGIVQIVVYTGAIMMLFLFVVMLVGVTAADSLKETLKGQRWLAALAALGFGILLIAGIGQVGISQFNGLAAANSGGNVQGLAALIFTKYVFAFEITGALLITATVGAMLLTHRERTERASTQRELAEKRVRENTHVPPLPAPGVYARHNAVDIPRLLPDGTPSELTVNKTLRERGQIRDVSQEALDDLKALEQRSAERLGRDREEENAQ
>NZ_CP016824.1|WP_008408177.1|2818352_2819051_-|NADH-quinone-oxidoreductase-subunit-NuoI
MTEGANQSDQGFQNPVAGFGVTFKAMFKKRLTEQYPEQPKTTAPRFHGRHQLNRHPDGLEKCVGCELCAWACPADAIYVEGADNTDEERYSPGERYGRVYQINYARCILCGLCIEACPTRALTMTNEFELADSSRENLIYTKDQLLAGLTEGMVDSPHAIFPGTDEQDYYRGLVTEAAPGTVRQPAVSKGEPAVVDSEPVAAAEGAPAAPAPASSPAASAGSAAKPGQEGQG
>NZ_CP016824.1|WP_067412932.1|2819043_2820420_-|NADH-quinone-oxidoreductase-subunit-NuoH
MSPILLAAEDLSMFGRDPWWLVLVKAVFCFAFLLLTVLFAIVWERKVVAWMQRRIGPNRAGPWGMLQSLADGAKLMLKEDVVVKRADKAVYVLAPVIAAIPAFMAFAVIPFGPADNQVSIFGQRTTMQLTDLPIALLYILAVASIGIYGIVLAGWSSGSTYPLLGSLRSCAQMISYEIAMGAAFASVFLYSGSMSTSTIVESQADRWYIVLLPVSFLIYIVTMVGEVNRAPLDMPESEGDLVGGFNTEYSSIKFAMFMLAEYINMVTVSAVAVTLFLGGWRAPFPVTAFWEGANQGWWPMLWFTLKLQLLLFLFIWLRGTLPRVRYDQLMKLGWKVLIPVSVVWLMLVATVRTLRNENMPFADIALYVFGGLIFLLLLSFVIDFYRDRRDQEREAGQRTEEPAFDPMAGGYPVPPLPGQALPPVPRRPARGERELVVSGAPDTVSDRGDTEGKEASDD
>NZ_CP016824.1|WP_067412935.1|2820502_2823031_-|NADH-quinone-oxidoreductase-subunit-G
MTVTTGAAPGTPAGVPPEDLVTLTIDGIEISVPKGTLVIRAAELLGIEIPRFCDHPLLDPAGACRQCIVEVEGQRKPMASCTIACTEGMEVRTQLTSPVAEKAQRGVMELLLINHPLDCPVCDKGGECPLQNQAMQVGDPDSRFEGKKRTYEKPVPISTQVLLDRERCVLCARCTRFSNQVAGDPMIELIERGALQQVGTGDGDPFESYFSGNTIQICPVGALTSAAYRFRSRPFDLVSSPSVCEHCAGGCATRTDHRRGKVMRRLAADDPEVNEEWMCDKGRFGFRYAQSPERLTQPLVRSESGVLEPASWPEALQAAARGLNAARGRAGVLTGGRLTVEDAYAYSKFARVALDTNDIDFRARPHSGEEADFLASQVAGRGRDLDGGGLTYADLEQAPAVLLAGIEAEEEAPGVFLRLRKAWRKKGQRTFALATHTTRGLTKAGGTLLPAAPRTETEWLKALGTGFGLEGVGQEAGEALRAEGSVIVVGERLATVEGGLTAAVRAAAALGARLVWIPRRAGERGAVEAGALPSLLPGGRPATDPRARDEVAAAWGVAELPPRYGRDTGQIVEAAASGELTALLVGGVEVADLPDPARARQALDRAEFVVSLEQRPSEVTERADVVLPVAAVAEKSGTFLNWEGRSRMFEAALKPEQMTRRLAPRDLRVLHMLADAVAEADETGRGELALPDIRAARRELDRLGGWDARPSRPAVPPEAPAGSALPRPAAGEAVLAGHRMLLDQGLLQRGDEALAGTRHAAPARLSAATAAEIGAADGTVLTVAGPAGSVELPLLVTDMPDRVVWLPLNSTGTGVASDTGAVPGQLVRIAPAAEAPAEVEES
>NZ_CP016824.1|WP_003948732.1|2823027_2824377_-|NADH-quinone-oxidoreductase-subunit-NuoF
MTVATEMNQTSPDKLLAPVLSAFWDQPESWTLETYRRHDGYEGLRKALAMSPDDLIAYVKDAGLRGRGGAGFPTGMKWQFIPQGDGKPHYLVVNADESEPGTCKDIPLLFANPHSLIEGIVIACYAIRSSHAFIYLRGEVVPVLRRLHEAVREAYEAGYLGKDVLGSGLDLDLTVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYACPTVVNNVESIASVPAILQQGKEWFRSMGSEKSPGFTLYSLSGHVAGPGQYEAPLGITLRQLLDMSGGMRPGHRLKFWTPGGSSTPMFTDEHLDVPLDYEGVGAAGSMLGTKALQCFDETTCVVRAVTRWTEFYAHESCGKCTPCREGTYWLVQLLRDIEAGQGKMSDLDKLNDIADNINGKSFCALGDGAASPIFSSLKYFRDEYEQHITGKGCPFDPAKSTLWADQHLEAKA

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Crispr_ID: NZ_CP016824_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_14

2913706-2913792

Orphan

Consensus_repeat	Method
CAGCCCGGCCCGCGCTTGAGGCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_14

>merge|NZ_CP016824|14|2913706-2913792|CRISPRCasFinder
CAGCCCGGCCCGCGCTTGAGGCCATCTTGTACGCACGCGGACGCTCCGGACCCCAGCCAAATCCAGCCCGGCCGGCGCTTGAGGCCA

>NZ_CP016824|14|13|2913706-2913792|CRISPRCasFinder
CAGCCCGGCCCGCGCTTGAGGCCA	TCTTGTACGCACGCGGACGCTCCGGACCCCAGCCAAATC
CAGCCCGGCCGGCGCTTGAGGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067413040.1\|2920020_2921793_-\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234829
NZ_CP016824.1\|WP_067413018.1\|2907722_2908451_-\|FMN-reductase	unknown	unknown	gnl\|CDD\|274935
NZ_CP016824.1\|WP_008415765.1\|2903233_2903878_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP016824.1\|WP_067413048.1\|2926633_2927314_+\|DUF4232-domain-containing-protein	unknown	unknown	gnl\|CDD\|379419
NZ_CP016824.1\|WP_003948814.1\|2907340_2907625_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234797
NZ_CP016824.1\|WP_067413032.1\|2916378_2917215_+\|DUF3558-family-protein	unknown	unknown	gnl\|CDD\|378803
NZ_CP016824.1\|WP_067413024.1\|2908447_2909551_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274934
NZ_CP016824.1\|WP_067413027.1\|2909898_2910405_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP016824.1\|WP_067413034.1\|2917298_2918186_-\|CDP-diacylglycerol--serine-O-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|224104
NZ_CP016824.1\|WP_067413037.1\|2918506_2919937_+\|DUF2637-domain-containing-protein	unknown	unknown	gnl\|CDD\|378511
NZ_CP016824.1\|WP_049977812.1\|2911999_2913433_-\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NZ_CP016824.1\|WP_018895841.1\|2910484_2910916_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|182266
NZ_CP016824.1\|WP_067413046.1\|2925140_2926466_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP016824.1\|WP_067413029.1\|2913891_2915085_-\|RtcB-family-protein	unknown	unknown	gnl\|CDD\|376465
NZ_CP016824.1\|WP_003948828.1\|2921961_2923761_+\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|215160
NZ_CP016824.1\|WP_067413043.1\|2923836_2925048_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP016824.1\|WP_031178407.1\|2906181_2907213_+\|sporulation-protein	unknown	unknown	gnl\|CDD\|369195
NZ_CP016824.1\|WP_008415763.1\|2903927_2905244_-\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607
NZ_CP016824.1\|WP_051721650.1\|2915320_2916253_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_078485272.1\|2905380_2906010_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067413040.1\|2920020_2921793_-\|lysine--tRNA-ligase	gnl\|CDD\|234829	PRK00750, lysK, lysyl-tRNA synthetase; Reviewed.	0
NZ_CP016824.1\|WP_067413018.1\|2907722_2908451_-\|FMN-reductase	gnl\|CDD\|274935	TIGR04037, predicted_flavoprotein, LLM-partnered FMN reductase, CE1759 family. This family represents a distinct clade within pfam03358. That family includes enzymes such as the NADH-dependent FMN reductase MsuE. Members of the present family regularly co-occur in genomes, typically as gene pairs, with members of TIGR04036, a probable FMN-dependent member of the bacterial luciferase-like monooxygenase (LLM) family. At least one member, RF\|YP_001509627.1 from Frankia sp. EAN1pec, is fused to the LLM protein. The function of these gene pairs is unknown.	8.76262e-95
NZ_CP016824.1\|WP_008415765.1\|2903233_2903878_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	2.5526e-40
NZ_CP016824.1\|WP_067413048.1\|2926633_2927314_+\|DUF4232-domain-containing-protein	gnl\|CDD\|379419	pfam14016, DUF4232, Protein of unknown function (DUF4232). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.	1.89981e-13
NZ_CP016824.1\|WP_003948814.1\|2907340_2907625_+\|hypothetical-protein	gnl\|CDD\|234797	PRK00575, tatA, Sec-independent protein translocase subunit TatA.	1.13467e-13
NZ_CP016824.1\|WP_067413032.1\|2916378_2917215_+\|DUF3558-family-protein	gnl\|CDD\|378803	pfam12079, DUF3558, Protein of unknown function (DUF3558). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.	0.00187948
NZ_CP016824.1\|WP_067413024.1\|2908447_2909551_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274934	TIGR04036, family_protein, putative luciferase-like monooxygenase, FMN-dependent, CE1758 family. This tightly conserved subfamily of the bacterial luciferase-like monooxygenase (LLM) family, with members showing > 60 % pairwise sequence identity, includes proteins from both species with and species without the ability to make coenzyme F420. Therefore, the like cofactor is FMN rather than F420. The presence of three members in Kineococcus radiotolerans SRS30216 and two in Saccharopolyspora erythraea NRRL 2338 suggest closely related (subfamily) rather than exactly conserved (equivalog) function. Gene neighborhoods around members are not conserved. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP016824.1\|WP_067413027.1\|2909898_2910405_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.46308e-13
NZ_CP016824.1\|WP_067413034.1\|2917298_2918186_-\|CDP-diacylglycerol--serine-O-phosphatidyltransferase	gnl\|CDD\|224104	COG1183, PssA, Phosphatidylserine synthase [Lipid metabolism].	3.56395e-36
NZ_CP016824.1\|WP_067413037.1\|2918506_2919937_+\|DUF2637-domain-containing-protein	gnl\|CDD\|378511	pfam10935, DUF2637, Protein of unknown function (DUF2637). This family of proteins has no known function.	7.07137e-40
NZ_CP016824.1\|WP_049977812.1\|2911999_2913433_-\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	8.84376e-112
NZ_CP016824.1\|WP_018895841.1\|2910484_2910916_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|182266	PRK10146, PRK10146, aminoalkylphosphonate N-acetyltransferase.	6.77373e-10
NZ_CP016824.1\|WP_067413046.1\|2925140_2926466_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	2.15146e-09
NZ_CP016824.1\|WP_067413029.1\|2913891_2915085_-\|RtcB-family-protein	gnl\|CDD\|376465	pfam01139, RtcB, tRNA-splicing ligase RtcB. This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyze the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage.	2.63422e-176
NZ_CP016824.1\|WP_003948828.1\|2921961_2923761_+\|arginine--tRNA-ligase	gnl\|CDD\|215160	PLN02286, PLN02286, arginine-tRNA ligase.	0
NZ_CP016824.1\|WP_067413043.1\|2923836_2925048_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	3.15559e-131
NZ_CP016824.1\|WP_031178407.1\|2906181_2907213_+\|sporulation-protein	gnl\|CDD\|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	9.38989e-101
NZ_CP016824.1\|WP_008415763.1\|2903927_2905244_-\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0

>NZ_CP016824.1|WP_049977812.1|2911999_2913433_-|SulP-family-inorganic-anion-transporter
MSPRRLWTEVLAGLVVALALIPEVISFSVIAGVEPAVGLFASFTTAVVISVVGGRPAMISAAAGAVALVIAPLNREHGLGYLIAAVILGGVIQIVLGVLGVARLMRFVPRAVMVGFVNALAVLIFLAQVPEMEHVPWAVYPLIVGGIALMVVFPRVTTVVPAPLVSIVVLTLITVGAGLAVPTVGDRGALPTSLPTPGLPDVPFTLDTLTLIAPYALALALVGLMESLLTAQLVDDLTDTPSDKRRESVGQGIANVVTGFFGGLGGCAMIGQTMVNVKTAGARTRLSTFLAGVFLLLLCLTLGPAVSAIPMAALVAVMVMVSFTTFDWRSIAPATLRRLPVGESAVMAVTVVFVVATHNLAVGVIAGCLAALGVFARRVAGRAELAVTRAPDGSTVRYAVTGDLFFASANGLADRFDYAGDPEKVVVDLGAARLWDASAVAVLDAIAAKYAQRGKDAEVTGLTGAGAELHARLSERA
>NZ_CP016824.1|WP_018895841.1|2910484_2910916_+|GNAT-family-N-acetyltransferase
MNIIDLAPGDPRLTADALPVLTELRPHLTPRLLEDVYAAGHPQGLRFTALYDVEGRCVAVAGWRVIANTSAIRKLYVDDLVTAEAARSTGAGRELVAYLEDRARELDCRVLDLDSGTQRTDAHRFYLRERFSIRAFHFSKLLR
>NZ_CP016824.1|WP_067413027.1|2909898_2910405_+|GNAT-family-N-acetyltransferase
MPWSEEDFPLLVAGNSEEMTAHLGGPESAEALAARHRRYLALDEGGDAGGRMFRITAAPPGTAHRPAGAIGFWLSEWQGRQVWESGWHVLPDLHGHGIATSAARLVAARAQAAGGPRTLHAFPSPTHAASNGVCRRAGFTLAGEARVEYPKGTWVACNDWRIDLDADG
>NZ_CP016824.1|WP_067413024.1|2908447_2909551_-|LLM-class-flavin-dependent-oxidoreductase
MQFGIFSVGDVTPDPTTGRTPTEAERIKAILRIAEKAEEVGLDVFATGEHHNPPFVPSSPTTMLGWVAARTENLILSTATTLITTNDPVKIAEDFAMLQHVADGRVDLMLGRGNTGPVYPWFGKDIREGIPLAVENYALLHKLWREDVVDWEGKFRTPLQSFTATPRPLDDVPPFVWHGSIRSPEIAEQAAYYGDGFFHNNIFWPMEHTKRMVRLYRNRYAHYGHGTPEQAIVGLGGQVFMRKNSQEAVREFRPYFDNAPVYGHGPSLEEFTSQTPLTVGSPQQVIERTLSFRKDVGDYQRQLFLMDHAGLPLKTVLEQLDILGEEVVPVLREEFAKDRPAGVPDAPTHASLRARARESADSEAVTK
>NZ_CP016824.1|WP_067413018.1|2907722_2908451_-|FMN-reductase
MTEFPLQSGDRPAAEAPDDLADDPRFSANEPVSPSGPLRVVVVSAGLSVPSSTRLLADRLGEAVARDLGAAEVPVRVDTVELRDLANDIAQNFTAGFPGPKLTAALDQVTGADAVIAVTPIFTASYSGLFKSFFDVLDQEALTGKPVLIAATGGSARHSLALEHALRPLFAYLRAVVVPTAVYAASEDWGNTDGLNRRIDRAAAELAALLAGTGGRRAAPAADPLEEVVPFAEQLAALRVQE
>NZ_CP016824.1|WP_003948814.1|2907340_2907625_+|hypothetical-protein
MLGISELAVILLVIVAVLAVKRLPDLARSSGKAARILKSEAKAMKEESRQGVDGQDRPGQAVYYATEPLPEQQPRPADGQQGRPDPQNPGSRPA
>NZ_CP016824.1|WP_031178407.1|2906181_2907213_+|sporulation-protein
MVFKRLLGSLGVGGPTVDTVLDAAPGSGSAAVPGGALTGRVHLKGGGSDFDISEITLELIARVEAETEEGEQHGTVAFERYVVGGGFRLAAETEQVVPFSVVLPWETPVSELYGQPLGIVLGVRTELAVAGAKDKGDLDPLAVGPLPAQEAILEALGQLGFGFRSADLEYGRIGGTGQQLPFYQEIELSPAPQYAHAVNEIEVTFLAHPGGLEVVLEADKRGGMFTPGHDALTRFTVSHEDVASRDWAAEVDGWVRQLVEHRAAYGTHASYGHHDPYAGGHHGHHDGHHDGHRSGPGMGTAIAAGAAGLAVGVAGGLVAAEVVDEVGDFFEGDDDEDDGGDEG
>NZ_CP016824.1|WP_078485272.1|2905380_2906010_+|hypothetical-protein
MHRGGGLGEGTGDLGPRRARRGKHRRDAASRAQDQAPARGGVEPVREGTDRGETGQSEIRSGGRVGVTYKYFGAPNGATAARVPLSMRPEELGGDELGMGGMFTRIKPETVSAMVLTGIEGIPLHRVPPLELVVLHPDYAVVKLPMTVVDPLRGIGEESVGAAAFIWSTVPDRGGPSDAFNVYQLLHEWQDFSHRLHEAGHQPYCLVWP
>NZ_CP016824.1|WP_008415763.1|2903927_2905244_-|glutamate-1-semialdehyde-2,1-aminomutase
MACVTYQYEAPVSQTLFDRAASVTPGGVNSPVRAFGAVGGTPRFMVSGTGPYLTDADGREYVDLVCSWGPMILGHAHPEVVAAVQEAVARGTSFGTPGEGEVALAEEIVARIEPVEQVRLVSSGTEATMSAIRLARGFTGRAKVIKFAGCYHGHVDALLAAAGSGLATFALPDTPGVTGAQAGDTIVLPYNDLDAVAAAFAAHPGEIACVITEAAPGNMGVVPPGEGFNAGLARLCRENGALFVSDEVMTGFRTSRAGWYGVEGVRPDLMTFGKVMGGGFPAAAFGGRADVMASLAPAGPVYQAGTLSGNPVATAAGLAQFRLLDQGAYDTIDAVSAELRGLVSAALAKEGVAHRVQNASNMFSVFFTADEVRDYDDAKRQESFRFTAFFHSMLAQGVYLPPSSFESWFVSTAHDDRAVERIAAALPAAARAAAEATA
>NZ_CP016824.1|WP_008415765.1|2903233_2903878_-|histidine-phosphatase-family-protein
MSADEITVVHLMRHGEVENPSGILYGRLPGYHLSELGRKMADRVAEHLAGRDITHVVASPLERAQETATPVAQAHGVELGSDARLIEAGNVFQGKTFGVGDGALRKPANWRHLTNPFRPSWGEPYIDQVVRMTKALDAAAAAARGHEAVLVSHQLPIWTVRSYVERRRLWHDPRRRQCSLASLTSFTYRGDRIVSVGYSEPARDLVPEHLLPRR
>NZ_CP016824.1|WP_067413029.1|2913891_2915085_-|RtcB-family-protein
MAYQEIPGARVPIRMWADPAGVEEAAMRQLQNVATLPWIKGLAVMPDVHYGKGATVGSVIAMRDAVCPAAVGVDIGCGMSAVRTSLTAGDLPGDLSRLRSRIEEAIPVGRGMHERPVDPTRTHGFGTNRWDAFWDRFDTVADSVHFRRERAAHQMGTLGSGNHFVEVCVDTDGDVWLMLHSGSRNIGKELADHHIGVARDLPHNQGLVDRDLAVFVADTPQMAAYRNDLFWAQEYARYNRTLMMDLLKQVVSREFKKARVAFDPEISCHHNYVSEERYDGMDLLVTRKGAIRAGSGDYGIIPGSMGTGSYIVKGLGNEASFNSASHGAGRRMSRNAAKRRFSLRDLAEQTRGVECRKDSGVVDEIPGGYKPIEQVIDQQRDLVEVVAQLKQVVCVKG
>NZ_CP016824.1|WP_051721650.1|2915320_2916253_+|hypothetical-protein
MARKAYPRRARVTGTLMLLVALGAAGCTGDPAAEDSPDAKPAGGQATTAQAEPGKYQTLPQPCRAVETGTLDAMLPGLAELDQEQRQKAYEGTSSVTYDSDRRTGCRWKVDSADAGHLLRIDFERVVSYSASVSDDARAQAVYGDRMKEADLPLPSDPREEQPERRADDSAKADRDEARATAPADDEAGQGASPETSEKPGKGEEEKEKGTGKSEEPADETVDPSAPAEGLEPRLLQELADDAFIDDQLTTSSSGSGQRTVTVVFRTSNVIVTVEYEAQPKQVAEVPDSASMQEKARELAVLLAERLSDV
>NZ_CP016824.1|WP_067413032.1|2916378_2917215_+|DUF3558-family-protein
MHRPAQRLTRILACAAVPVMLVAAGCSSDDSSGGKDAQQDKPASSSAASAPAVEKAAYATLPEACSTLSKKTLKDLVPDADSLKGKTGKSDDTASRATCSWNSLDNKGVDGSQFRWLHVSLMRFDSDEALGSGAKRAEKYYAKQIADAKATEDAKKVAAEPVSGTGDAATVVSYELKKKEGTFKQQSLVTRVENVVVTVDYNGAGLAGQSSPKTAGLVEDATKAGKEAVAAVTKANSSDAKGSSDADSGKEPEKDADKKSTKEDDDDNAGQGAAPGKS
>NZ_CP016824.1|WP_067413034.1|2917298_2918186_-|CDP-diacylglycerol--serine-O-phosphatidyltransferase
MTTTDRDRAALRAEDTPEEPRRNAGRDVDQGVSGEAPGRSGRQPSPSRLSAADILTLGNAVCGFSSVYFITTAVLVPYLTGGPGDGTLRQGAATAVMLILLASLFDLCDGLVARKFRSSGMGAELDNLSDLISFGLAPAYFVVVWGLVGEGSHLWLTVVGAVAVLLAGVLRLARFSVTTSRDGMFEGMPIPFAALTVVSVVLLELPFALTLALVVGVAWLMVSRVEYPKPTGRMAVATVVWAAVNIGCLVAWAAGAPGAERLLVTGCALQLSLAALLPLVATGRRLKARRDRRSA
>NZ_CP016824.1|WP_067413037.1|2918506_2919937_+|DUF2637-domain-containing-protein
MAATELTRTHRILIGVVVAGAVVIAAIGFAGSYTAVRELALQKGFGTFSYFFPIGIDAGICVLLALDLLLTWMRIPFPMLRQTAWLLTAATIAFNGAAAWPDPLGVGMHAVIPVLFVVAVEAARHAIGRIADITADKHMEGVRITRWLLSPLPTFLLWRRMKLWELRSYEQVIKLEQERLVYQARLRSRFGRAWRRKAPVESLMPLRLARYGVPLAETAPAGLAAAGIEPALLPPPPAPARQELERADRPVAETDPAPAPTTSLEKQPADRPAAEAPQERQAPPPEGSPWFAGQQGPVQYEGTYDPQYEPDPQTFAEYQRYQRFAAHEAQEAQAAREAEVQQEAAEEERRDGVQVPAGPGRTRPLGGAPAIPAQREGEEPEESRPAPPQDEAPQVPGGGAIDEETFFAAFRRYVEVNGNYPNARKFGLYLQDHHQVSNEAGGPLPEGDLWPYLRECRRRYEQEQAQAAPEPDFTSA
>NZ_CP016824.1|WP_067413040.1|2920020_2921793_-|lysine--tRNA-ligase
MPIVAQSTETADWVSRYADEVIAEAERRAGAKKADGTADGAPGTDGLTVVVASGLSPSGPIHLGNLREVMTPHLVADEVRRRGHTVRHLISWDDYDRYRKVPAGVAGIDESWAEHIGKPLTAVPAPAGSAYPNWAEHFKAAMTEALDALGVEYDGISQTTQYTSGAYREQILHAMRHRGDIDAILAQYRTKKAPGKKSQKPVDEAELEAAEGSGAAAEDDGTTAGGGYYPYKPYCTVCNKDLTTVTSYDDETTELSYTCACGHAETVKLSTFDHGKLVWKVDWPMRWAYEGVIFEPSGVDHSSPGSSFQVGGQIVEIFDGVRPIGPMYAFVGISGMAKMSSSKGGVPTPADALKIMEPQLLRWLYARRRPNQSFKIAFDQEIQRLYDEWDKLEAKVAEGAALPADAAAHSRAAATAAGELPRTPRPLPYRTLASVADITAGAEDQTLRILSELDPAHPITGLDEVRPRLDRAEAWINTYVDAEARTVVRAEPDTEALAGLGDEARESLRLLLDGLDSHWSLDGLTTLVYGVPKIQAGFPADAKPTPELKAAQRSFFALLYQLLVGRDTGPRLPTLLLAVGEDRVRRLLGA
>NZ_CP016824.1|WP_003948828.1|2921961_2923761_+|arginine--tRNA-ligase
MASVTSLTASVHQRLADALAAALPEAGAADPLLRRSDRADYQANGILALAKKLKGNPRELATKVVDAIGADEVIQDIEVSGPGFLNLTLSDAAITRNLAARAADPARLGVPLAEAPGTTVIDYAQPNVAKEMHVGHLRSAVIGDAVVRMLEFTGEQVVRRHHIGDWGTQFGMLIQYLIEHPGELAATAESAAVEAGQASVEAGEQAMSSLNRLYKASRALFDSDEEFKTRARRRVVDLQAGDPETLAMWQRFVDESKVYFYSVFNKLDMEIHDADVVGESGYNAMLAETCRLLEESGVAVRSEGALCVFFDDVKGPDGQPVPLIVQKSDGGFGYAATDLSAIRDRVFQLKADTLLYVVDARQSLHFKMVFETARRAGWLGEDVKAVQLAFGTVLGKDGKPFKTREGETVRLVDLLDEAVERATAVVREKDVKEQLTEEQIAERGAEVGIGAVKYADLSTSAARDYKFDLDQMVSLNGDTSVYLQYAYARIRSILRRAGEARPVAHPELALAPAERALGLHLDQFGEIASDAAAEYAPHKLAAYLYQTASLYTTFYDQCHVLSADNPPELVENRLFLCDLTGRTLHQGMELLGIRTPEQL
>NZ_CP016824.1|WP_067413043.1|2923836_2925048_-|PLP-dependent-aminotransferase-family-protein
MSLSPAATVPTPPLAGRAVGGGGSPVGDILAVTARPEVINFAGGLPARELFDAEGIAEAFRAVLAEQAPRALQYATTEGEPALRGALAGRMTARGLATEADDVLVTTGSQQGLSLVAQALIEPGDTVLVESPCYLAALQVFAFAGARIVPVACDDDGIDPAALEELVVRERPKFLYTVPTFQNPTGRTMTADRRREVARIAARRGLWIVEDDPYGELRFAGERLPWIASLPEAADRTVLLGSFSKVMAPGLRLGWLRAPPPLRAACALVKEGTDLHTPTVNQLAAARYLADNDLDAHVARVAAVYGTRRDALLAGLPDALPAGSTWTTPQGGMFVWARLPEGHDTAALLRTVVGFDVAYVPGAPFFAGRPDHGTLRLCFVTQTPDEIAEGLRRLEKGFAAAAG
>NZ_CP016824.1|WP_067413046.1|2925140_2926466_-|helix-turn-helix-domain-containing-protein
MGTADSTGEAERLAALLSTLKERSGLSYGALGKRLHLSASTLHRYCNGDAVPADFAPLNRFARLCRATPEELVEVHRRWILADAAREQRGKGAGGTAGGAAPAADPGTPADPPDADDTPKSPDTPETQETQETQETPDSPSAPRPRPRRRLILAATAGVIAVAATAALLVGRLVDDGAGAGAGQAAGAARGPVASPEAAESPSPSPSGSASGKPSASPSPSGTPGASPGSPADGKPAAPAPTGVPFHASVRAHAWENQCSQRYLVDREPDAVRPPPVEQDAPAWVAAMGAVSADEQVVEVTLQGKGSETVVLQALHVRVVRTGEPLPWTDYGTGVGCGGGVALRTFDVDLDQGSPAARAAEGQRPFPYKISESDPEMFRVTAHTGGRDVSWYLEVEWSSGERQGVFRVDDRGRPFRTSASAGRPAYDYPPGASEWSEHQPG
>NZ_CP016824.1|WP_067413048.1|2926633_2927314_+|DUF4232-domain-containing-protein
MTATPRSRRLRTLAAALVTTAALSLTACQTGTADATGVVDSTQPPAPGTESAEEQPPAAEKETGTSGASGNSAKEATQVAGRKAPAKTTSCTAKGTKVTVTDAPRPINHLLIKATNTSDTTCHLYYAPYLRFDQAQSAVPFIEESKPQAVVTLEPGESGYAGVLTSTPDGSHPYDATSLTLYYAARSGQGSTGAPSHPALPFDPVRIDSSNAVTYWQTSAADALMW

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Crispr_ID: NZ_CP016824_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_15

3107802-3107904

Orphan

Consensus_repeat	Method
CCAGCCCGGCCGGCGCTTGAGGCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_15

>merge|NZ_CP016824|15|3107802-3107904|CRISPRCasFinder
CCAGCCCGGCCGGCGATTGAGGCCATCCCGGACAGGGCTGTCGAGGCCCGCAGGCAGGAGCGGGGCGTCAGCCACATCCCAGCCTGGCCGGCGCTTGAGGCCA

>NZ_CP016824|15|14|3107802-3107904|CRISPRCasFinder
CCAGCCCGGCCGGCGATTGAGGCCA	TCCCGGACAGGGCTGTCGAGGCCCGCAGGCAGGAGCGGGGCGTCAGCCACATC
CCAGCCTGGCCGGCGCTTGAGGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067413197.1\|3108117_3109647_-\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl\|CDD\|334815
NZ_CP016824.1\|WP_079165333.1\|3097314_3098175_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
NZ_CP016824.1\|WP_003948938.1\|3098246_3098717_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379209
NZ_CP016824.1\|WP_003948942.1\|3100633_3101239_-\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472
NZ_CP016824.1\|WP_067413203.1\|3114860_3115523_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP016824.1\|WP_067413194.1\|3101385_3103428_-\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
NZ_CP016824.1\|WP_067413189.1\|3099319_3099919_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|223872
NZ_CP016824.1\|WP_003948948.1\|3109783_3110272_+\|inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|376376
NZ_CP016824.1\|WP_015507656.1\|3105743_3106964_-\|zinc-dependent-metalloprotease	unknown	unknown	gnl\|CDD\|274833
NZ_CP016824.1\|WP_008406585.1\|3103697_3104237_-\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NZ_CP016824.1\|WP_067413200.1\|3110511_3112161_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NZ_CP016824.1\|WP_008411387.1\|3112224_3112926_-\|membrane-protein	unknown	unknown	gnl\|CDD\|182775
NZ_CP016824.1\|WP_008406583.1\|3104348_3105569_-\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|274129
NZ_CP016824.1\|WP_075986980.1\|3098954_3099323_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
NZ_CP016824.1\|WP_031178734.1\|3116394_3117900_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143469
NZ_CP016824.1\|WP_003948941.1\|3100062_3100551_+\|DUF3180-domain-containing-protein	unknown	unknown	gnl\|CDD\|378650
NZ_CP016824.1\|WP_003948951.1\|3113021_3113780_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377906
NZ_CP016824.1\|WP_030310644.1\|3118027_3118891_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP016824.1\|WP_061404696.1\|3115640_3116207_-\|DinB-family-protein	unknown	unknown	gnl\|CDD\|368218
NZ_CP016824.1\|WP_003948952.1\|3114212_3114839_+\|NAD(P)H:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|179647

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067413197.1\|3108117_3109647_-\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl\|CDD\|334815	pfam02113, Peptidase_S13, D-Ala-D-Ala carboxypeptidase 3 (S13) family.	2.49389e-59
NZ_CP016824.1\|WP_079165333.1\|3097314_3098175_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	1.0623e-109
NZ_CP016824.1\|WP_003948938.1\|3098246_3098717_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379209	pfam13474, SnoaL_3, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	1.34894e-26
NZ_CP016824.1\|WP_003948942.1\|3100633_3101239_-\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	1.11788e-115
NZ_CP016824.1\|WP_067413203.1\|3114860_3115523_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	4.07501e-10
NZ_CP016824.1\|WP_067413194.1\|3101385_3103428_-\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP016824.1\|WP_067413189.1\|3099319_3099919_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	3.9779e-63
NZ_CP016824.1\|WP_003948948.1\|3109783_3110272_+\|inorganic-diphosphatase	gnl\|CDD\|376376	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase.	1.73356e-85
NZ_CP016824.1\|WP_015507656.1\|3105743_3106964_-\|zinc-dependent-metalloprotease	gnl\|CDD\|274833	TIGR03883, DUF2342_F420, uncharacterized protein, coenzyme F420 biosynthesis associated. A phylogenetic tree of the DUF2342 family (TIGR03624) consists of two major branches. One of these branches, modeled here, is observed almost entirely to be found in coenzyme F420 biosynthesizing species of the Actinobacterial, Chloroflexi and Archaeal lineages. The few organisms having genes within this family and lacking F420 biosynthesis may either have an undiscovered F420 transporter, or may represent F420-to-FMN revertants. This family includes a Chloroflexus Aurantiacus protein whose crystal structure has been determined (PDB:3CMN_A). This has been annotated as a putative hydrolase, but the support for that assertion is untraceable. There is no cofactor present in the structure.	1.56493e-158
NZ_CP016824.1\|WP_008406585.1\|3103697_3104237_-\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	1.73523e-91
NZ_CP016824.1\|WP_067413200.1\|3110511_3112161_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	9.45317e-58
NZ_CP016824.1\|WP_008411387.1\|3112224_3112926_-\|membrane-protein	gnl\|CDD\|182775	PRK10847, PRK10847, DedA family protein.	6.69657e-53
NZ_CP016824.1\|WP_008406583.1\|3104348_3105569_-\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|274129	TIGR02432, tRNAIle-lysidine_synthase, tRNA(Ile)-lysidine synthetase, N-terminal domain. The only examples in which the wobble position of a tRNA must discriminate between G and A of mRNA are AUA (Ile) vs. AUG (Met) and UGA (stop) vs. UGG (Trp). In all bacteria, the wobble position of the tRNA(Ile) recognizing AUA is lysidine, a lysine derivative of cytidine. This family describes a protein domain found, apparently, in all bacteria in a single copy. Eukaryotic sequences appear to be organellar. The domain archictecture of this protein family is variable; some, including characterized proteins of E. coli and B. subtilis known to be tRNA(Ile)-lysidine synthetase, include a conserved 50-residue domain that many other members lack. This protein belongs to the ATP-binding PP-loop family ( pfam01171). It appears in the literature and protein databases as TilS, YacA, and putative cell cycle protein MesJ (a misnomer). [Protein synthesis, tRNA and rRNA base modification].	8.48739e-59
NZ_CP016824.1\|WP_075986980.1\|3098954_3099323_+\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	8.67586e-45
NZ_CP016824.1\|WP_031178734.1\|3116394_3117900_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143469	cd07151, ALDH_HBenzADH, NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like. NADP+-dependent, p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid and other related sequences are included in this CD.	0
NZ_CP016824.1\|WP_003948941.1\|3100062_3100551_+\|DUF3180-domain-containing-protein	gnl\|CDD\|378650	pfam11377, DUF3180, Protein of unknown function (DUF3180). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	1.3504e-27
NZ_CP016824.1\|WP_003948951.1\|3113021_3113780_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|377906	pfam07739, TipAS, TipAS antibiotic-recognition domain. This domain is found at the C-terminus of some MerR family transcription factors. The domain has an alpha-helical globin-like fold. The family includes Mta a central regulator of multidrug resistance in Bacillus subtilis.	3.57422e-46
NZ_CP016824.1\|WP_030310644.1\|3118027_3118891_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	9.88909e-09
NZ_CP016824.1\|WP_061404696.1\|3115640_3116207_-\|DinB-family-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	1.59267e-38
NZ_CP016824.1\|WP_003948952.1\|3114212_3114839_+\|NAD(P)H:quinone-oxidoreductase	gnl\|CDD\|179647	PRK03767, PRK03767, NAD(P)H:quinone oxidoreductase; Provisional.	5.85773e-46

>NZ_CP016824.1|WP_015507656.1|3105743_3106964_-|zinc-dependent-metalloprotease
MTSIGGVEMVDWKLAVTTASRLARPGPEITREEAREVVAELRGHAVAAEEHVRAFTGMTTAAGHDTPVLVVDRPGWIEANVAGFRSLLKPLMTKMRARRGNGPGGMIAGAVGGKVTGVELGVLLSFLSSRVLGQYETFAPATRELPGAPDGGGRLLLVAPNIVHVERELGVDPHDFRLWVCLHEETHRTQFTAVPWLRDHLEAEIQAFLAETDVDAGTLLERLSDAVQAFTGGRRGESAEPSATGTATDTATATASETEPGARSGAHAPEQDIDGRSLVDLVQTPAQREILARVTAVMSLLEGHADYVMDGVGPQIVPSVVEIREKFQRRRAAGANRLDQILRRLLGLDAKLRQYRDGERFVRAVVEEVGMEGFNRVWTSPNTLPTAAEITHPAEWIARVHRGPEA
>NZ_CP016824.1|WP_008406583.1|3104348_3105569_-|tRNA-lysidine(34)-synthetase-TilS
MGPHPAVAAIRLAVRRVLNDLLAEHPHPHPQPLAGQPGRPPRAELLERVGRATRAGRARQIRARAASGAPVQVPAPGEAPGAAPPAEGPLVLVACSGGADSMALASALAFEAPRLGIRAGGITVDHGLQYGSDARAADVVARLTALGLDPVESAAVRVAAASDRTAHGAPYAGGARRVGPEAAARDARYAALDEAAERLGAAAVLLGHTRDDQAETVLLGLARGSGIRSLSGMAAVSGDSGRYRRPFLQLDRQTARTACLAQSLPVWDDPHNTDPAYTRSRLRHEGLPALEKALGKGVVEALARTAQLSRDDADALDAWAAREEAAVRDETGELDCARLYALPAAVRRRILRRALVAAGAPGGSLFARHVEEVDRLITGWRGQRAINLPGKVEARRQGGRLVLRQG
>NZ_CP016824.1|WP_008406585.1|3103697_3104237_-|hypoxanthine-phosphoribosyltransferase
MGSDLQSVLLTKEEIDAKLVELAEQIDQEYAGKDLLIVGVLKGAVMVMADLARTLSTPVTMDWMAVSSYGAGTQSSGVVRILKDLDTDIQGKHVLIVEDIIDSGLTLSWLISNLGSRGPASLKVCTLLRKPEAAKVAIDVEWVGFDIPNEFVVGYGLDFAEKYRNLPFVGTLAPHVYGG
>NZ_CP016824.1|WP_067413194.1|3101385_3103428_-|ATP-dependent-zinc-metalloprotease-FtsH
MDVKRYFRGPVMWIVLAVLAVVVLMQVVGSSGGHKTVDTGQVVQAINDKQVQSASLTTGDDQMIKVDLKDGQKIDGSTKIQASYIGDMGFDLARKLQAGYEDKSIPEGYTVSPSKQSPFLSILLSLLPFVLIVLVFLFLMNQMQGGGSRVMQFGKSKAKLITKDTPKTTFADVAGSDEAVEELHEIKEFLQEPAKFQAVGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFEQAKANAPAIVFVDEIDAVGRHRGAGMGGGHDEREQTLNQLLVEMDGFDVQGGVILIAATNRPDILDPALLRPGRFDRQIAVDRPDMQGRLEILKVHVKGKPVAPDVDLSAVARRTPGFTGADLANVLNEAALLTARSDQKLIDNHMLDEAIDRVVAGPQKRTRIMSDKEKKITAYHEGGHALVAAASPNSDPVHKITILSRGRALGYTMVLPEEDKYSTTRNEMLDQLAYMLGGRAAEELVFHDPTTGAANDIEKATGTARAMVTQYGMTERLGAIKFGGDNTEPFLGRDMAHQRDYSEEVAALVDEEVKKLIETAHNEAWEILVENRDVLDNLVLQLLEKETLGKEEIAEIFATIVKRPARPAWTGSTRRTPSTRPPVLSPKELSLTNGANGSPAALGTGPPNGSTPDLTKPPASPEDRPEE
>NZ_CP016824.1|WP_003948942.1|3100633_3101239_-|GTP-cyclohydrolase-I-FolE
MTDPVTLDGLGAIGEFDEKRAEHAVRELLLAVGEDPDREGLRETPARVARAYREIFAGLWQKPEDVLTTTFDLGHDEMVLVKDIEVQSSCEHHLVPFVGVAHVGYIPSADGKITGLSKLARLVDVYARRPQVQERLTTQIADSLMEILEPRGVIVVVECEHMCMTMRGVRKPGAKTITSAVRGQLRDAATRNEAMSLIMAR
>NZ_CP016824.1|WP_003948941.1|3100062_3100551_+|DUF3180-domain-containing-protein
MKQLRIRTLAGLLVVAAVLSWAGARLWDAFGTLPAVPLFAPIVLAAIAAVLLATALAFRSRLRAQRERRPEAKGVDPLVAARALVFGQASALVAALVAGMYGGVTVFLLGYLEVPARADQALYAGTSLVAGAGVIAAGLYLERVCKLPEDGDDNTPGAAPTV
>NZ_CP016824.1|WP_067413189.1|3099319_3099919_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MNPNSSDPTVQPVPASVVEQVDAADVTLSNPKTAVISLGSNLGNRLETLQGAVDALEDTPGLRVKAVSPVYETEPWGVDPGSQPSYFNAVAVIRTTLPPGSLLERAQAVEEAFHRVRDERWGPRTLDVDIVAYAGVVSADPELTPPHPHAHERAFVLAPWHDVDPEAELPGQGPVDELLSALAGDGLTRREDLELRLPE
>NZ_CP016824.1|WP_075986980.1|3098954_3099323_+|dihydroneopterin-aldolase
MIRVDRVALRGLKGRGHHGVFPKEREEGQTFIVDLVLGLDTRPAAESDDLTRTVHYGVVAEEVVAVVEGEPVNLIETLAERIARTCLKTDAVQEVEVTVHKPDAPITVPFDDVTVTITRSRV
>NZ_CP016824.1|WP_003948938.1|3098246_3098717_+|nuclear-transport-factor-2-family-protein
MTPTEIEQVERANAEYYDIVERGDYAELAALWLDEESLSCVHPGWPVLSGRGEVLRSYAVIMANTDYIQFILTDVQTSLLGATAIVTCTENILSGGPPPEDGELGPLVGQLVVATNVFRRTTEGWKLWSHHASPVLAELEAEEGDGDGGPGEESPA
>NZ_CP016824.1|WP_079165333.1|3097314_3098175_+|dihydropteroate-synthase
MSTSFGRGRVAGLPEWDRCAVMGVVNVTPDSFSDGGRWFDSERAVKHGLDLASRGADLIDVGGESTRPGAPRVDEAEELRRVVPVVRALAAEGLVVSVDTMRAAVAEQSLAAGALLVNDVSGGLADPAMIPAVAAAGAPFVVMHWRGFSDAMNSRAVYADVVGEVTDELRTRIDAAVDGGIAPDRIVVDPGLGFAKEAPHDLALVAHLDRLRALGHPLLVAASRKRFLGRVLAGPDAAPPPARERDAATAAISALSARAGAWAVRVHDVRPTADAVRVARAVEAAR
>NZ_CP016824.1|WP_067413197.1|3108117_3109647_-|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MSGRGGWRLKTWQFTAAAAVSGLALASAAAAAAGPWDSGGQRTAESRRAALLPGTGDGDHRTEAGSPLPAGSDPVASEAAAVLAPLEAGDLAPRTGEGAREAAAGQAPAPTAAALKFALEPLLKAKGLGPGATASVVDAATGKELYGRGAKTAMVPASTVKIATGTAALSVLGPDHRIRTTVVAEPGPGYEDGAPPERIVLVGGGDPTLTARADAAGNASLRTLARHAADTLKQRGARTVRLAYDTSAYSGSTRHPIGPNENLAPVTALMADEGRLDTSTSGPAPRSTRPAQDAADAFARFLAERGVKVEGAVREATATDQAEKLADVRSAPLSALVERMLTHSDNDIAEALARQTALAAGAKADFAGAERETRRALGRLGLPLDGARFADGSGLDRADRVTARLLTSLLARAAHTDHPELRPVLTGLPVAGFSGTLAGRYTDPEAAAGTGVVRAKTGTLTGVNTLAGTVVSTDGRLLTFSFLASATTDPTTAQSTLDHLASTLAHCGC
>NZ_CP016824.1|WP_003948948.1|3109783_3110272_+|inorganic-diphosphatase
MEFDVTIEIPKGSRNKYEVDHETGRIRLDRRLFTSTSYPADYGFVEDTLGEDGDPLDALVLLDDPTFPGCLISCRVIGMFRMTDEAGGDDKLLCVPAGDPRVDHLKDIQDVSEFDRLEIQHFFEVYKDLEPGKSVEGADWVGRAEAEAEIERSYQRAKEAGH
>NZ_CP016824.1|WP_067413200.1|3110511_3112161_+|threonine/serine-exporter-family-protein
MTEDADDRKPQSDEARSAFTPPQGVPQSQAPENESQITSEFALPEGLAAPPAGEDAERSAFTPPATYDARSAPPAFTPAQGIPMVRLAKNSPWQDRMRAMIRLPVAERPAPDLTQKTDDSGPAVPRVLDLTLRIGELLLAGGEGAEDVEAAMFAVSRSYGLDRCEPNVTFTLLSISYQPSLVDDPLTASRTVRRRGTDYTRLAAVFGLVDDISSDDTEVSLEEAYRRLAEIRRNRHPFDTWALTLAAGLLAGGASMLVGGGLVVFVAAALGAIAGDRMAWVFAGRGLPEFYQFAVAAMPPAAIGIALQLAHVEVRASAVITGGLFALLPGRALVAGVQDGLTGYYITAAARLLEVMYLFIGIVVGVLVMLYVGVQLGAELQPREALLSVERPPIQIIAAMALTLAFAVLLQQERSTVLLVTLNGGVAWSVYGAMHFAGNISPVASTAVAAGLVGLFGQLLSRIQFASALPYVTAAIGPLLPGSATYYGLLGIVQGDVNTGLSSLSTAIALALAIAIGVNLGGETARLFLRVPRGPDAATRRAAKRTRGF
>NZ_CP016824.1|WP_008411387.1|3112224_3112926_-|membrane-protein
MNTLALGPSWLDPDYLLNQFGIYGLLLIVFAESGLLIGFFLPGDSLLFTTGLLITTSQLKFPLWLAIVLICVAAIVGDQAGYLFGKKVGPALFKRPDSRLFKQENVTKASEFFDKHGPKSLVLARFVPIVRTFTPIIAGVSSMRYRSFITFNILGGILWGAGVTLLGAWLGQIAFVRENIEAMLILIVLVSVVPIIIEFVKARGQSKRAAAAGPGAGPTPPPAPPQRGRHAKR
>NZ_CP016824.1|WP_003948951.1|3113021_3113780_-|MerR-family-transcriptional-regulator
MEYTVGQVAAVAGVTVRTLHHYDAIGLLSPSGRSAAGHRRYGDGDLDRLQRILFHRALGFALDEIAALLDDPDADPRAHLRRQHALLTDRIETLRRMADAVAAAMEAAQMGINLTPEEKFEVFEGYDPDQYADEARQRWGHTDAYRESQRRTASYTKADWQRLKDEFDALHARVAELLAQGVPADAPEAMDAAEEHRRFIDGAHYPCDARMHTCLADMYVADPRFTATYEAIRPGLAQYLHDAIHANARRTE
>NZ_CP016824.1|WP_003948952.1|3114212_3114839_+|NAD(P)H:quinone-oxidoreductase
MPGTVNVAVIYYSSTGTIARIADAMATAATEAGAHVRLRKVRELAPQAAIDSNPAWAANADATKDLPEAEPDDMVWADAVIFGSPTRYGNVSAQLKQFIDTLGGLWAEGRLADKVYSGFTASSTAHGGQESTLLALYNTVHHFGGILVAPGYTDPSKFVDGNPYGTSHVSGQGDLPVGDQTLQATKVQAERVVRVARALKEGGLTGGA
>NZ_CP016824.1|WP_067413203.1|3114860_3115523_-|PadR-family-transcriptional-regulator
MSAIRMLVLGAVRQHGRAHGYQVRNDLEFWGAHEWSNAKPGSIYHALKQLARQGLLVAHETAPSTAGGPPRTEYSVTEEGEEEFFRLLRAALTGYDQKPDLLYAALGFLVDLERAEAVALLQERLRSIQEWRRSVTEYWTPEAGPESIGHIGEIMNLWVHSADTGAEWTRGLIARIEAGAYTFAGEGEPFRGILTEGEPNPYATEGNPYREGAPPAARPE
>NZ_CP016824.1|WP_061404696.1|3115640_3116207_-|DinB-family-protein
MVVHVDPEARGDERGALLAFLDAERGGIRRALLGLSDQAAATRPSASELSLSGLLKHVRLTEQSWLERATGTAPEPAEGETYADQEHGYELVGEETVASELAAWEAVARRTEEFIHAAETLDATFALPDAPWFPPGQRVSLRWLLLRLITETARHAGHADIIRESLDGAVAFELVAKERGEERGEEWG
>NZ_CP016824.1|WP_031178734.1|3116394_3117900_-|aldehyde-dehydrogenase-family-protein
MSDSTVPAGAAASGPGFADFGRLAHQYIDGRWRTGTGSWDIIDFNPFNGEKLAAITVATVSEVDEAYRAAERAQKPWAAAGPHARRTVLEKALRITEEHTAQIVEAMCEEQGATRSKARHEVEMACEFLREAIRLTVRPEGVILPASQRSRENRVYRLPVGVVGVISPFNFPFLVALKTVAPALALGNAVVVKPNQNTPVVGGGLIARIFEEAGLPAGLLNVVVTDIAEIGDALIAHPVPRVISFSGSDRVGRHVGAVAASHLKRTVLELSGNSALVVLADADVDYAVDAAVFSRFVYQGQVCMAANRILVDRSVEAEFTEKFTARVRALRTGDPREEETDLGPVISDFQADALSAMVDRALAEGATALVRGRTLGNLVEPTVLAGVPADSALLHQEIFGPVVVLVPFDGDDEAVRIANDTPYGLSGAVHTADAERGVNFAHRVETGMIHVNDSTVQDDPQVAFGGEKASGSGRLNGEATVEAFTTQKWISVQHGRSIFPF
>NZ_CP016824.1|WP_030310644.1|3118027_3118891_-|helix-turn-helix-domain-containing-protein
MTAGESGGSVVRRILLGSQLRRLREGRGITREAAGYSIRASESKISRMELGRVSFKARDVEDLLTLYGVADGAERAALLDLAREANVAGWWHSYSDVLPGWFQTYVGLEGAASLIRVYEVQFVHGLLQTEAYAHAVVERGMPGASAAEIDRRVALRLERQKLLVSERAPGFHVVLDEAALRRPYGDRTVMREQLEHLIEISERPNVTLQVMPFSFGGHAGESGAFALLRFPESDLSDVVYLEQLTSALYLDKREEVAQYERAMERLQRDSPDPSRTRDLLRGVVQLT

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Crispr_ID: NZ_CP016824_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_16

3358032-3358118

Orphan

Consensus_repeat	Method
TGGCCTCAAACGCCGGCCGGGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_16

>merge|NZ_CP016824|16|3358032-3358118|CRISPRCasFinder
TGGCCTCAAACGCCGGCCGGGCTGGGATATGCCGGGGTTCGGCTGTGCCCTGCCGGTCAAAGATGGCCTCAAGCGCCGGCCGGGCTG

>NZ_CP016824|16|15|3358032-3358118|CRISPRCasFinder
TGGCCTCAAACGCCGGCCGGGCTG	GGATATGCCGGGGTTCGGCTGTGCCCTGCCGGTCAAAGA
TGGCCTCAAGCGCCGGCCGGGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067413580.1\|3356431_3357994_-\|malate-synthase-A	unknown	unknown	gnl\|CDD\|236432
NZ_CP016824.1\|WP_067413565.1\|3351056_3351773_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|378676
NZ_CP016824.1\|WP_067413560.1\|3348441_3349416_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137
NZ_CP016824.1\|WP_067413575.1\|3353042_3353441_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003949208.1\|3353625_3354045_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224639
NZ_CP016824.1\|WP_067413586.1\|3359999_3361412_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226322
NZ_CP016824.1\|WP_018470165.1\|3361430_3361853_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067413595.1\|3368528_3369662_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NZ_CP016824.1\|WP_008408873.1\|3371059_3371749_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274926
NZ_CP016824.1\|WP_008408879.1\|3367661_3368459_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP016824.1\|WP_067413572.1\|3352590_3353046_+\|HIT-family-protein	unknown	unknown	gnl\|CDD\|238608
NZ_CP016824.1\|WP_003949215.1\|3362913_3363948_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP016824.1\|WP_067413562.1\|3349819_3350746_-\|TIGR03620-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274681
NZ_CP016824.1\|WP_067413592.1\|3364226_3367547_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173800
NZ_CP016824.1\|WP_067413583.1\|3358237_3359521_-\|isocitrate-lyase	unknown	unknown	gnl\|CDD\|237893
NZ_CP016824.1\|WP_107436718.1\|3362095_3362904_+\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|379129
NZ_CP016824.1\|WP_003949210.1\|3355081_3356098_+\|transporter	unknown	unknown	gnl\|CDD\|372253
NZ_CP016824.1\|WP_010644733.1\|3354116_3355085_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP016824.1\|WP_067413568.1\|3351878_3352352_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_079165338.1\|3369658_3370813_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|182464

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067413580.1\|3356431_3357994_-\|malate-synthase-A	gnl\|CDD\|236432	PRK09255, PRK09255, malate synthase; Validated.	0
NZ_CP016824.1\|WP_067413565.1\|3351056_3351773_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|378676	pfam11575, FhuF_C, FhuF 2Fe-2S C-terminal domain. This family consists of several bacterial ferric iron reductase protein (FhuF) sequences. FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. This domain is the C-terminal domain that contains 4 conserved cysteine residues that are found to be part of a 2Fe-2S cluster.	0.000155286
NZ_CP016824.1\|WP_003949210.1\|3355081_3356098_+\|transporter	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	0.00512449
NZ_CP016824.1\|WP_003949208.1\|3353625_3354045_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	1.82109e-19
NZ_CP016824.1\|WP_067413586.1\|3359999_3361412_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|226322	COG3800, COG3800, Predicted transcriptional regulator [General function prediction only].	1.79439e-148
NZ_CP016824.1\|WP_107436718.1\|3362095_3362904_+\|IS5-family-transposase	gnl\|CDD\|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	2.50059e-20
NZ_CP016824.1\|WP_067413595.1\|3368528_3369662_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	1.14389e-75
NZ_CP016824.1\|WP_008408873.1\|3371059_3371749_+\|hypothetical-protein	gnl\|CDD\|274926	TIGR04025, hypothetical_protein, PPOX class probable FMN-dependent enzyme, DR_2398 family. Members of the PPOX family (see pfam01243) may contain either FMN or F420 as cofactor. This subfamily consists of proteins mostly from species that lack the capability to synthesize F420, and therefore most likely all bind FMN.	5.64901e-79
NZ_CP016824.1\|WP_008408879.1\|3367661_3368459_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	8.33355e-135
NZ_CP016824.1\|WP_067413572.1\|3352590_3353046_+\|HIT-family-protein	gnl\|CDD\|238608	cd01277, HINT_subgroup, HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. Although the biochemical function has not been characterised for many of the members of this subgroup, the proteins from Yeast have been shown to be involved in secretion, peroxisome formation and gene expression.	2.65488e-42
NZ_CP016824.1\|WP_067413562.1\|3349819_3350746_-\|TIGR03620-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|274681	TIGR03620, F420_MSMEG_4141, probable F420-dependent oxidoreductase, MSMEG_4141 family. Members of this protein family, related to F420-dependent oxidoreductases within the larger family of a bacterial luciferase (an FMN-dependent enzyme), occurs only within the small subset of species that synthesize F420. Most such proteins are from members of the Actinobacteria, but at least one species, Sphingomonas wittichii, belongs to the Alphaproteobacteria. [Unknown function, Enzymes of unknown specificity].	1.75936e-102
NZ_CP016824.1\|WP_067413592.1\|3364226_3367547_+\|S8-family-serine-peptidase	gnl\|CDD\|173800	cd07474, Peptidases_S8_subtilisin_Vpr-like, Peptidase S8 family domain in Vpr-like proteins. The maturation of the peptide antibiotic (lantibiotic) subtilin in Bacillus subtilis ATCC 6633 includes posttranslational modifications of the propeptide and proteolytic cleavage of the leader peptide. Vpr was identified as one of the proteases, along with WprA, that are capable of processing subtilin. Asp, Ser, His triadPeptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	6.70818e-79
NZ_CP016824.1\|WP_067413583.1\|3358237_3359521_-\|isocitrate-lyase	gnl\|CDD\|237893	PRK15063, PRK15063, isocitrate lyase; Provisional.	0
NZ_CP016824.1\|WP_003949215.1\|3362913_3363948_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	2.3819e-63
NZ_CP016824.1\|WP_010644733.1\|3354116_3355085_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.69005e-60
NZ_CP016824.1\|WP_067413560.1\|3348441_3349416_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	1.18158e-14
NZ_CP016824.1\|WP_079165338.1\|3369658_3370813_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	4.72141e-89

>NZ_CP016824.1|WP_067413580.1|3356431_3357994_-|malate-synthase-A
MPPTTLAPTGAQASQDTDALLTPAALSFLAELHTAFAHRRTPLLEERRTRSALLARGAPLDFLPATQAVRQDRTWHIAPPAPGLADRRTELTTPPTRAAAKAALTSGAQLWTADFEDATSPSWPNILTGHLTLLDLVEGRLTAPEGHTAPTVAVRPRGWHLTERHLLVDGDPLPAPLADFGLYAFHRARRRTAPADGPYFSLPKLENHREARLWNEIFTFAERTLGLAHGTIRATVLIETVTAAFEMDEILYELRDHAAGLTAARWDYLFSLVKTVGHRPGTVLTDRSRAVMTAPYLRAWTDLLVRTAHRRGAHAIGGLTAQVLTGDPAADEAVCAAVRRDKEREAEEGFDGSWVAHPSLVPLARAAWDTALGARPHQLERTRDDVHVTPADLLRTGRDHGRPGTETVRATLALCLRYYDAWLRGDGAPVLDGVVEDTSGAEICRAQIWQWLRHGAVDRPTVLALLDSETAALAAADPAARHREARDIFVRGALGPELPEFFTTEASARHLTGPVARHWT
>NZ_CP016824.1|WP_003949210.1|3355081_3356098_+|transporter
MSTATLERESATDRDPGPRRLLHGMTWLVWRQHRGALWTGLALVAALVVTAVLLRNGAVAHQAAHGITGCPLMGGPERCSSSLEAIEEYRGLYSTPLRLLLAGILALPFLGGLFVGAPLIARELEADTHRLVWAQGITRERWLLHKLALPMGALMAGTGVAAWFGSWALEGAGQATIGLYWYSPTAFVSTGPAVLGYAALGVALGAMAGTLTRRTLPAMVLTLGAMGAVTALLTTIRSHVVSPVVSFGRSVPQLREEDWVLVQPQAARADRTIFDAGPCYPADDFDACLAEHGASWEYSEHHPIAHMRDLQLAEGAICLGLAALAVTFVWLWMRRRAF
>NZ_CP016824.1|WP_010644733.1|3354116_3355085_+|ABC-transporter-ATP-binding-protein
MYTEQFDPADAGLVALEATGLGKRYRRGWALEECAFRLPAGRICGLVGPNGAGKSTLMSLATGVSGPSAGTLRVFGGDPRGGRARRQVGYLAQSKPLYPRLSVADTLRMGRELNGDSWDQGRAEAIVRGGDIPFHARAGSLSGGQRTRLALALCFGKRPRMLLLDEPMADLDPLVRHEMTGVLMAEAAESGTTVVMSTHTLPELEGVCDYLLVLAGGRVRLAGEADELAWAHSLVTGVLPAPGAASPLDGHTVVESTTGGRQFTAMVRRRGSLAPGPTWTVAEPSMEQLLLAYLRSPEASPLLTPSATPPAPTHLAAKDHAA
>NZ_CP016824.1|WP_003949208.1|3353625_3354045_+|GntR-family-transcriptional-regulator
MITYQIERRSGVATYMQIVLQTKQALRLGVLVPGDKLPTAKEVVETAAINPHTVLKAYRELEREGLVELQPGRGTFVRRGLGSTDAASQAPLREELTAWLRKAEEAGLDADDAAALFDACRAEVYATADSPSQAGPTHP
>NZ_CP016824.1|WP_067413575.1|3353042_3353441_+|hypothetical-protein
MSQYYEVGDETLWNPSIGASRLFLAHVRLHEDELGMASGLGPMDGDECQIEAGAFREYTEALVARHLRTGHHVILALSEGFVATVLVLARRAGIEPDALRAEATTAPVQGDGGAARERLEALAARLDRAMAR
>NZ_CP016824.1|WP_067413572.1|3352590_3353046_+|HIT-family-protein
MGAERGCLFCAIARGEAEASTVHEDERVVAFMDLQPVTPGHVLVVPKAHAAGFEDLPEELGAEVWRVAHRIGRGLRRSGLRCEGVNLFLADGEAAFQEIPHVHLHVFPRYAGDSFRLDADWQVRDRAELDAAAGAVRTGLTALGDDGGVPA
>NZ_CP016824.1|WP_067413568.1|3351878_3352352_-|hypothetical-protein
MSDQHETPHPREAHSGAHHAAADVPEDDAPRQAWATGGTVLAGVLLLLQGVFGFLQGIAGIADNTVYAGLGDYAFKMSVTSWGWIHLFLGVLVAITGWCILTGQTWAKATGVGLAAVAVILNFMWLPYLPLWALLNIALGIFVIWALCTERPDAPTL
>NZ_CP016824.1|WP_067413565.1|3351056_3351773_+|(2Fe-2S)-binding-protein
MTTSLAPLLTRLTAVGPYFAADPTPRADPSEGGFRPVAELYGDGIAGHVEEIGRRMGTGAGRVAASTAQLGLASRLWSVALGCAALGGVAPDLGPGRLWWRGPSAGPVELRLPGPRPLPGPLPEALHRAVAVDHLAPLDEAVRGRYALSPQILRGNAASALVGAVRVLLDRVPDAPCPPVPLVEHLLARAPLEGTGTFLHEEGLGVAFTRRSCCLYYRVPAATCGDCVQRTRPPRRSA
>NZ_CP016824.1|WP_067413562.1|3349819_3350746_-|TIGR03620-family-F420-dependent-LLM-class-oxidoreductase
MTSTPGTDPATTAAHELGIGTVGIWSGALRVSDGTGRDGAITDAVEEIEALGYGAIWVGGSASVADAEAVLAATHHLRVATGILSIWDHPAERVAEQASDANRAHDDRFILGIGASHQQLAPEEYAKPYTAMREYLTALDEAPHPVPARQRVLAALGPKMLQLSKDRAAGAHPYLVSEDYVAEAREALGTGPLLAPELKVVLDDNLPRARETARAYLRFYLELPNYTNNLRRAGFGPADFENGGSDALLDAVVAYGDADRIRTRVTAFHKAGADHVALQVVTPNPMQDLPIAEWRALAAALELPGATG
>NZ_CP016824.1|WP_067413560.1|3348441_3349416_+|glycosyltransferase-family-2-protein
MEPSQPVSGEDEEVAGGGRVGGAAVSLEEAARTSYVGRRAPVVAVLMTSRNRRRQLLRALDALADQRSLPPGTALRVHLVDAGSRDGTAEAVRAAHPEVEVHRAGPRVRWGEGIRMASRNSRAAGATPFTHQFWLRDDVILADEALALLLATSRALGDTAVVVGAVRDGGVPGARPGNGPLAYSGRRRTRVPHRLPLVEPSGRTEPCDTYDGAAVLLPRAARDRAGDLDRAFRHTLGDLDHGLRARRVQVPAFVAPRAVGERHAVPLPPTWEEPGIGVREALRRRAGELPPRAWWTYCRRHAGVRAPLLAAAPYLRTAVRAARG
>NZ_CP016824.1|WP_067413583.1|3358237_3359521_-|isocitrate-lyase
MAQTPTEAATELARRWAEDPRWKDIERTHTAEDVVRLSGSVREEHTLARRGAERLWRQLHERDYVHALGALTGGQAVQMVKAGLQAIYLSGWQVAADANQAGHTYPDQSLYPVNSVPTVVRRINNALLRADQIATAENAGDTTDWLAPIVADAEAGFGGPLNAFELTKAMIAAGAAGIHYEDQLASEKKCGHLGGKVLVPTSQHVRTLNAARLAADIADVPTLIVARTDALAANLLTSDVDEQDARFATGERTAEGFYRVEPGMAPVIARGLAYAPYADLIWVETGTPHLAQAREFAEALHAQYPDKMLAYNCSPSFNWKAALDDDQIAKFQRELGAMGYRFQFITLAGFHSLNHGMFDLARGYAEHGMTAYVDLQEREFAAQAQGFTAVKHQREVGTGYFDLVSTAINPASTTTALTGSTEEQQFH
>NZ_CP016824.1|WP_067413586.1|3359999_3361412_+|XRE-family-transcriptional-regulator
MSKTYAGARLRRLREERRLSQVELARILSISPSYLNQMEHDSRPLTVPVLLRISESFGVDPGFFSERDTGRLIADLRETLADDLAASRVSSADLAELASRLRGVAQVLLSLGRRADLLTDRLAEVSEGRADTGPAAARSPHEEIREFFYRRRNYLHETDLAAEELAAETGVRPGGVLAALDGRLAERHGVRTATGADTGRPHHYDADARVLHLSPRLRPGQQAFRMATQLALLEQDAELSATASEEFTESTVAWSLARIGIAHYFAAALILPYRAFHGAAEEVRYDIERLTDRFGLGYETVCHRLSTLQRPRLRGVPFSFVRVDRAGNMSKRQSATGFHFSRAGGTCPLWNLYEAFTAPGRVHVQTVSMPDGSRYLWTARAVTRRGGGWGDPGKTFSIGLGCELRHASRLVYSDGLDLANAAADTPIGMGCRVCERLDCPQRAVPPLGRALSVDENTGTFVPYPVKGEQN
>NZ_CP016824.1|WP_018470165.1|3361430_3361853_-|hypothetical-protein
MKSTSTDTAYQERDVQAGAGAEAAGRKARVHPAVPAGLIAGSYVLALLLQLAGAPTAVLSVALLMRIVGCVLLCTSLFWRPWQKVTGVLVTLVVPALANILWNRELSGEDTMALRVLADVLQLVCVVGGAAWLWWTRRKD
>NZ_CP016824.1|WP_107436718.1|3362095_3362904_+|IS5-family-transposase
MRADLVPDDLWERVAPLLPPAPERRHRYPGRLRVPDRAALAGVMYVLRTGVAWRDVPAEAVGCSGVTAWRRLRDWTEAGVWPRLHAILLSELRRAGLLDLDDCAVDGSHVRALKRGDHTGPSPVDRARPGSKHHVIVDRHGTPLAVTLTGGNRHDVTQLLPLLDAVPPIRGLRGRPRRNPRRLYADRGYDFDKYRRLLWKRGVKPVIARRGVAHGSGLGKVRWVVERAFAWLHQFKRLRIRYERRADLHQGLLELACSLICLRRLRTSF
>NZ_CP016824.1|WP_003949215.1|3362913_3363948_-|iron-siderophore-ABC-transporter-substrate-binding-protein
MNDSAFSGKAARSSRRRKTATLAGAVAALLVGLTACGAGGDEQAEKPAEGKASSGAFPAKVATKFGEITIDEAPKRIVALGWGDAETALALGAQPVGASDWLPFGGEGVGPWAKGMYDKKPELIGTMEPEFEKIAALKPDLILDTKSSGDQTRYDTLSKIAPTVGVPKGGDMYMTSWEKQTEMVAGALGKKDEGAELIAETEKKFAAAAKEHPEFKDKTITVGSRTSEGFGAYVGGTGRVDFVKRLGFVNNPEIEKLAGDSFSVSVSKEKLDLLDADLTVMAPIGISAKEISDDPLYKAVPSVKDGRSIVFDDKDISQAFATDSVLSVGYALDKVVPLFSEKLK
>NZ_CP016824.1|WP_067413592.1|3364226_3367547_+|S8-family-serine-peptidase
MVAAAVAVALAAGTAPSAVAQPDPRGTSGDRAHAPDRVKRHLTLVTGDRVGLDADGTPVTFRPAKGRERIPVKRMSDRGHTLVVPADAHRLVVSGKLDRRLFDITELSRPENLRAQRDGLKLIVGYRGKQAHAAKAQVREAGGTEVGRSLTSLNAESVTTPAGDVPEIWKALTAGPGDGERVTTAAGIDRVWLDGVRRASLDKSVPQIGAPTAWKAGFTGKGVKIAVLDTGTDATHPDLKGQVLAEKNFSSAEDTVDRVGHGTHVASIAAGTGAASGGAFKGVAPDAKLLAGKVLDDDGFGEDSGILAGMEWAVAQGADIVNLSLGGTDTPEVDPLEAAVDKLSAEKGVLFAIAAGNEGDGAGTVGSPGSADAALTVGAVDDKDELADFSSRGPRVEDGAVKPDVTAPGVDTTAAIPSDSLIAQEVGENPAGYATISGTSMATPHVAGAAALLKQQHPKWSYAELKGALTASAQPGPYNPFQQGSGRIAVDGALKQTVVADPVSVSFGVQQWPHTDDEPVTEQVRYRNTGTADVTLDLKVTGTGPKGKPAPAGFFTLGADRVTVPAGGTAEVALTADTRLGGDADGTYAAYLVATGDGQTVRTAAAVEREVESYDLTVKHLGRDGRPAAGAETTVFRFDAGADFLDPQVVDGTAKIRVPKGTYVVDSNVYQAPEDVTKGVDWIAQPKVAVTKDTTLTFDARKAKPVKITVPDSKAESQIFSPDYGVETEDDAVTFGWVADSPAGMRTLHVGPKITDGSLTQHWSGTWTRGATTQFDIAVGGKVERLATGYSRKFTTGQLAKVKLAMGAAAPKKTGEVTAWPLLPSQNSGWVVSGEQKLPGTRTLYLSTADQVRWDMDFSQLGDLDEEGFPAYETGYQVAAGAVFRPGWTYRKSVNTAVFGPLVNKEFGVFRDGNEIGGYLPLLADGRGNPGGIELSKATSVLYRNGKETGRNSDPLAGEEVFRVPAAAADYRLKATVRHSAKISPLSTRVDVDWTFRSKKTGDHTPLPVSTVRFSPEVAADGTAKAGKTVSVPVKVQGAAAGKNLKSLTTYVSHDGGKNWKKVPVKKGKITVKNPAKGKAVSFAAKVTDKKGNTSKVRIYSAYLGK
>NZ_CP016824.1|WP_008408879.1|3367661_3368459_-|ABC-transporter-ATP-binding-protein
MSAEHTLEARDVRIGYDGREIVPGLSVKIPPGRFTVIVGPNACGKSTLLRAMARLLAPTSGAVLLDGRPVQQTPTREVASVLGILPQSPVAPEGITVSDLVARGRYPHQGWFRRWTAEDDAAVGAALLSTDVLDLAERPVDELSGGQRQRVWIAMALAQRTDILLLDEPTTFLDVAHQMDVLDLLTDLNRERGVTLVAVLHELNMACRYADHLIAMKQGEVVAEGAPSDIVTEQLVSDVFGMRCSVVPDPASGTPLVVPLGRHHV
>NZ_CP016824.1|WP_067413595.1|3368528_3369662_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MSDRATSSFEKADAEKAAPARTDASPLHVSEAVLAEAARTVAGARRRGGRRSVLVGLVLALAAFAVFAVSLSVGDMVVPLADVLATLFGGGDAGAQFVVLELRLPRALLAVLVGAGFGMAGAVFQTVLRNPLASPDVIGISSGASAAAVTASMVFAVSGLALSASALIGALIAGTLIYLLAWRKGVVGARLVLVGLGVGFGLNSLVWYLMSRAEVSNAQNALLWLTGSLNGRSWNQVWPQLIALAVLVPLTFAAAGALPALQLGDDTASGLGARAERNRLALLACGVALAGVSTAAAGPVAFVAFVAAPVARMLLPGRGAVLPHAALAGALLVLLADFAAQHALPGTQLPVGVVTSVVGAPYLLWLLARANRVGRGG
>NZ_CP016824.1|WP_079165338.1|3369658_3370813_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MNGPADREGRPADPSGTPPSPTRSTALLDLGKRPDAEGATATAAPPPRRSVRSRPALAAGLVLALVGLGLTLVASLAVGSGDVPFADVLGTFLDPDAENKAQLIVGEVRIPRTVAGLLSGVALGLAGTVMQGVTRNPIADPSLLGINAGASLSVVFAISVLGLGASQQYLWFGFLGALIAALVVYGVGSLGREGATPVKLALAGAATTAVLTSLTTTMLLTDRQSYDQFRFWQIGALNTRSVEVLSEAAPFIVVGGLLALTLGSQLNALALGDDLARGFGQRVGLVRGVSAVAVVLLCGASTVVAGPIGFVGLAVPHIARLVTGPDYRWVLPYSMVLAPMLLLWADIVGRVVAQPGEVQVGVVTAALGCVPFIWLVRRRKLVEL
>NZ_CP016824.1|WP_008408873.1|3371059_3371749_+|hypothetical-protein
MTNPAPEAPATGLHHSLARLTRVPDARGLGLTGPAVPAAPLVPEAPATSPLPAGYTELTGVEELDALLGVPHPIVIDKVHDRLDAQDLDLLSRSSFCSLSTADAEGNCDVSPRGGVPGFTHVVDPGTLALPDRPGNRRGDSFRNILTNPHVGLLYLVPGVMDVLRINGRARILTDAPFFDALVEKNQRPKLALVVEIDEIYRHCPASLRRSGIWSPDTWENAAGGTSPA

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Crispr_ID: NZ_CP016824_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_17

3374804-3374899

Orphan

Consensus_repeat	Method
AGGAGGCAGAGGTTGGCGCCCTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_17

>merge|NZ_CP016824|17|3374804-3374899|CRISPRCasFinder
AGGAGGCAGAGGTTGGCGCCCTGGGTGTTGGTGACCCGGGCCGGGTCGTTCGTGCCGGTCGTGCAGTGGGCGAGGAGGCAGAGGTTGGCGCCCTGG

>NZ_CP016824|17|16|3374804-3374899|CRISPRCasFinder
AGGAGGCAGAGGTTGGCGCCCTGG	GTGTTGGTGACCCGGGCCGGGTCGTTCGTGCCGGTCGTGCAGTGGGCG
AGGAGGCAGAGGTTGGCGCCCTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_003949238.1\|3389422_3389776_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|163261
NZ_CP016824.1\|WP_067413616.1\|3389906_3390368_+\|DUF2269-family-protein	unknown	unknown	gnl\|CDD\|370783
NZ_CP016824.1\|WP_067413603.1\|3375353_3385643_+\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
NZ_CP016824.1\|WP_067413608.1\|3385925_3386948_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|130256
NZ_CP016824.1\|WP_067413614.1\|3388727_3389426_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377452
NZ_CP016824.1\|WP_067413605.1\|3385719_3385929_+\|MbtH-family-protein	unknown	unknown	gnl\|CDD\|377081
NZ_CP016824.1\|WP_067413595.1\|3368528_3369662_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NZ_CP016824.1\|WP_030765879.1\|3374289_3374688_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_008408879.1\|3367661_3368459_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP016824.1\|WP_067413611.1\|3387856_3388555_-\|sensor-domain-containing-protein	unknown	unknown	gnl\|CDD\|379374
NZ_CP016824.1\|WP_067413597.1\|3371929_3373156_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226614
NZ_CP016824.1\|WP_067413592.1\|3364226_3367547_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173800
NZ_CP016824.1\|WP_067413619.1\|3390382_3391627_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_CP016824.1\|WP_067413623.1\|3392010_3392679_+\|DUF998-domain-containing-protein	unknown	unknown	gnl\|CDD\|377627
NZ_CP016824.1\|WP_003949226.1\|3373133_3373499_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|377953
NZ_CP016824.1\|WP_003949215.1\|3362913_3363948_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP016824.1\|WP_008408873.1\|3371059_3371749_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274926
NZ_CP016824.1\|WP_015507582.1\|3373634_3373988_-\|PRC-barrel-domain-containing-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_079165338.1\|3369658_3370813_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|182464
NZ_CP016824.1\|WP_003949235.1\|3386935_3387736_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_003949238.1\|3389422_3389776_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|163261	TIGR03433, padR_acidobact, transcriptional regulator, Acidobacterial, PadR-family. Members of this protein family are putative transcriptional regulators of the PadR family, as found in species of the Acidobacteria. This family of proteins has expanded greatly in this lineage, and where it regularly is found in the vicinity of a putative transporter protein [Regulatory functions, DNA interactions].	8.53379e-30
NZ_CP016824.1\|WP_067413616.1\|3389906_3390368_+\|DUF2269-family-protein	gnl\|CDD\|370783	pfam10027, DUF2269, Predicted integral membrane protein (DUF2269). Members of this family of bacterial hypothetical integral membrane proteins have no known function.	0.00177358
NZ_CP016824.1\|WP_067413603.1\|3375353_3385643_+\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NZ_CP016824.1\|WP_067413608.1\|3385925_3386948_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	1.35774e-114
NZ_CP016824.1\|WP_067413614.1\|3388727_3389426_-\|hypothetical-protein	gnl\|CDD\|377452	pfam05088, Bac_GDH, Bacterial NAD-glutamate dehydrogenase. This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyze the reversible oxidative deamination of glutamate to ketoglutarate and ammonia.	0.000460361
NZ_CP016824.1\|WP_067413595.1\|3368528_3369662_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	1.14389e-75
NZ_CP016824.1\|WP_008408879.1\|3367661_3368459_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	8.33355e-135
NZ_CP016824.1\|WP_067413611.1\|3387856_3388555_-\|sensor-domain-containing-protein	gnl\|CDD\|379374	pfam13796, Sensor, Putative sensor. This family is often found at the N-terminus of proteins containing pfam07730 and pfam02518. The N-termini of proteins containing these two domains often function in stimulus sensing.	1.11335e-25
NZ_CP016824.1\|WP_067413597.1\|3371929_3373156_+\|hypothetical-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	4.14655e-12
NZ_CP016824.1\|WP_067413592.1\|3364226_3367547_+\|S8-family-serine-peptidase	gnl\|CDD\|173800	cd07474, Peptidases_S8_subtilisin_Vpr-like, Peptidase S8 family domain in Vpr-like proteins. The maturation of the peptide antibiotic (lantibiotic) subtilin in Bacillus subtilis ATCC 6633 includes posttranslational modifications of the propeptide and proteolytic cleavage of the leader peptide. Vpr was identified as one of the proteases, along with WprA, that are capable of processing subtilin. Asp, Ser, His triadPeptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	6.70818e-79
NZ_CP016824.1\|WP_067413619.1\|3390382_3391627_-\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	7.97043e-87
NZ_CP016824.1\|WP_067413623.1\|3392010_3392679_+\|DUF998-domain-containing-protein	gnl\|CDD\|377627	pfam06197, DUF998, Protein of unknown function (DUF998). Family of conserved archaeal proteins.	5.72261e-10
NZ_CP016824.1\|WP_003949226.1\|3373133_3373499_-\|PH-domain-containing-protein	gnl\|CDD\|377953	pfam08000, bPH_1, Bacterial PH domain. This family contains many bacterial hypothetical proteins. The structures of Structure 3hsa and Structure 3dcx show similarities to the PH or pleckstrin homology domain. First evidence of PH-like domains in bacteria suggests role in cell envelope stress response.	4.12332e-63
NZ_CP016824.1\|WP_003949215.1\|3362913_3363948_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	2.3819e-63
NZ_CP016824.1\|WP_008408873.1\|3371059_3371749_+\|hypothetical-protein	gnl\|CDD\|274926	TIGR04025, hypothetical_protein, PPOX class probable FMN-dependent enzyme, DR_2398 family. Members of the PPOX family (see pfam01243) may contain either FMN or F420 as cofactor. This subfamily consists of proteins mostly from species that lack the capability to synthesize F420, and therefore most likely all bind FMN.	5.64901e-79
NZ_CP016824.1\|WP_067413605.1\|3385719_3385929_+\|MbtH-family-protein	gnl\|CDD\|377081	pfam03621, MbtH, MbtH-like protein. This domain is found in the MbtH protein as well as at the N-terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.	3.44283e-27
NZ_CP016824.1\|WP_079165338.1\|3369658_3370813_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	4.72141e-89
NZ_CP016824.1\|WP_003949235.1\|3386935_3387736_+\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	3.50315e-20

>NZ_CP016824.1|WP_030765879.1|3374289_3374688_+|hypothetical-protein
MTKHQAARILIGAGAAFGLVLGATGAANAAPSNPIKTQGGYAQWNADPSGSIPGDSIRACDNTADGWGIEAWLDINRDGTIDRIASTRGHNAPYCTSWKSGDIPEGTPVTVYAVTVNGGIVLEKGGALWSKA
>NZ_CP016824.1|WP_015507582.1|3373634_3373988_-|PRC-barrel-domain-containing-protein
MSDGIWGYQPTAGHTAGTDLIGYKVEATDGTIGKVDKHSDEVGSAYLVVDTGVWIFGKHVMLPAGTVRTVDGAERKIHVELTKEQIKNSPEFDKDRHAGDAQYHDQLGGYYGGHRPL
>NZ_CP016824.1|WP_003949226.1|3373133_3373499_-|PH-domain-containing-protein
MALFGNAHTVDPGSAQQEYARLLGQGEQVHAAYLLIRDTILFTDRRLILVDKQGITGKKVEYHSIPYRSITHFAVETAGTFDLDAELKIWLSGATTPVQKTFTKGVDIYEVQAILTQFVTR
>NZ_CP016824.1|WP_067413597.1|3371929_3373156_+|hypothetical-protein
MSDTATGEKWERVADWGRRLRRPESSARRSLLLILKSALAATVSWFVSYELMNATSPAFAPFSAVLMVQVTVYQSVVQSLRYVGAVAAGVAVQAVLGLSAGPDLVTFALVALVALIISRWRLLGAQGSQVATAAFFAFATYTGASSDTDQVKELGQIVVLVLIGSAVGVGVNVLIAPPLRYRSAEWGIRALAQEIHDLLDTMAPELGEGAPDADTTQGWRDRADRTGTLISQSREGLRTARESLRLNPHPWARRRRGTLTFEAYDRTMEALVRMISQVTAITRSLDLQHQDEKQQEEESGPDQDYAPFLRAYATFLSSVVDFTEILATLDEDHLRDQAGRLDEAADGLERCRREVVRTTEDRGLSLTDPTEPYGVLVVEATRLSEECRYTADVLGNSAENGSSGSRTA
>NZ_CP016824.1|WP_008408873.1|3371059_3371749_+|hypothetical-protein
MTNPAPEAPATGLHHSLARLTRVPDARGLGLTGPAVPAAPLVPEAPATSPLPAGYTELTGVEELDALLGVPHPIVIDKVHDRLDAQDLDLLSRSSFCSLSTADAEGNCDVSPRGGVPGFTHVVDPGTLALPDRPGNRRGDSFRNILTNPHVGLLYLVPGVMDVLRINGRARILTDAPFFDALVEKNQRPKLALVVEIDEIYRHCPASLRRSGIWSPDTWENAAGGTSPA
>NZ_CP016824.1|WP_079165338.1|3369658_3370813_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MNGPADREGRPADPSGTPPSPTRSTALLDLGKRPDAEGATATAAPPPRRSVRSRPALAAGLVLALVGLGLTLVASLAVGSGDVPFADVLGTFLDPDAENKAQLIVGEVRIPRTVAGLLSGVALGLAGTVMQGVTRNPIADPSLLGINAGASLSVVFAISVLGLGASQQYLWFGFLGALIAALVVYGVGSLGREGATPVKLALAGAATTAVLTSLTTTMLLTDRQSYDQFRFWQIGALNTRSVEVLSEAAPFIVVGGLLALTLGSQLNALALGDDLARGFGQRVGLVRGVSAVAVVLLCGASTVVAGPIGFVGLAVPHIARLVTGPDYRWVLPYSMVLAPMLLLWADIVGRVVAQPGEVQVGVVTAALGCVPFIWLVRRRKLVEL
>NZ_CP016824.1|WP_067413595.1|3368528_3369662_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MSDRATSSFEKADAEKAAPARTDASPLHVSEAVLAEAARTVAGARRRGGRRSVLVGLVLALAAFAVFAVSLSVGDMVVPLADVLATLFGGGDAGAQFVVLELRLPRALLAVLVGAGFGMAGAVFQTVLRNPLASPDVIGISSGASAAAVTASMVFAVSGLALSASALIGALIAGTLIYLLAWRKGVVGARLVLVGLGVGFGLNSLVWYLMSRAEVSNAQNALLWLTGSLNGRSWNQVWPQLIALAVLVPLTFAAAGALPALQLGDDTASGLGARAERNRLALLACGVALAGVSTAAAGPVAFVAFVAAPVARMLLPGRGAVLPHAALAGALLVLLADFAAQHALPGTQLPVGVVTSVVGAPYLLWLLARANRVGRGG
>NZ_CP016824.1|WP_008408879.1|3367661_3368459_-|ABC-transporter-ATP-binding-protein
MSAEHTLEARDVRIGYDGREIVPGLSVKIPPGRFTVIVGPNACGKSTLLRAMARLLAPTSGAVLLDGRPVQQTPTREVASVLGILPQSPVAPEGITVSDLVARGRYPHQGWFRRWTAEDDAAVGAALLSTDVLDLAERPVDELSGGQRQRVWIAMALAQRTDILLLDEPTTFLDVAHQMDVLDLLTDLNRERGVTLVAVLHELNMACRYADHLIAMKQGEVVAEGAPSDIVTEQLVSDVFGMRCSVVPDPASGTPLVVPLGRHHV
>NZ_CP016824.1|WP_067413592.1|3364226_3367547_+|S8-family-serine-peptidase
MVAAAVAVALAAGTAPSAVAQPDPRGTSGDRAHAPDRVKRHLTLVTGDRVGLDADGTPVTFRPAKGRERIPVKRMSDRGHTLVVPADAHRLVVSGKLDRRLFDITELSRPENLRAQRDGLKLIVGYRGKQAHAAKAQVREAGGTEVGRSLTSLNAESVTTPAGDVPEIWKALTAGPGDGERVTTAAGIDRVWLDGVRRASLDKSVPQIGAPTAWKAGFTGKGVKIAVLDTGTDATHPDLKGQVLAEKNFSSAEDTVDRVGHGTHVASIAAGTGAASGGAFKGVAPDAKLLAGKVLDDDGFGEDSGILAGMEWAVAQGADIVNLSLGGTDTPEVDPLEAAVDKLSAEKGVLFAIAAGNEGDGAGTVGSPGSADAALTVGAVDDKDELADFSSRGPRVEDGAVKPDVTAPGVDTTAAIPSDSLIAQEVGENPAGYATISGTSMATPHVAGAAALLKQQHPKWSYAELKGALTASAQPGPYNPFQQGSGRIAVDGALKQTVVADPVSVSFGVQQWPHTDDEPVTEQVRYRNTGTADVTLDLKVTGTGPKGKPAPAGFFTLGADRVTVPAGGTAEVALTADTRLGGDADGTYAAYLVATGDGQTVRTAAAVEREVESYDLTVKHLGRDGRPAAGAETTVFRFDAGADFLDPQVVDGTAKIRVPKGTYVVDSNVYQAPEDVTKGVDWIAQPKVAVTKDTTLTFDARKAKPVKITVPDSKAESQIFSPDYGVETEDDAVTFGWVADSPAGMRTLHVGPKITDGSLTQHWSGTWTRGATTQFDIAVGGKVERLATGYSRKFTTGQLAKVKLAMGAAAPKKTGEVTAWPLLPSQNSGWVVSGEQKLPGTRTLYLSTADQVRWDMDFSQLGDLDEEGFPAYETGYQVAAGAVFRPGWTYRKSVNTAVFGPLVNKEFGVFRDGNEIGGYLPLLADGRGNPGGIELSKATSVLYRNGKETGRNSDPLAGEEVFRVPAAAADYRLKATVRHSAKISPLSTRVDVDWTFRSKKTGDHTPLPVSTVRFSPEVAADGTAKAGKTVSVPVKVQGAAAGKNLKSLTTYVSHDGGKNWKKVPVKKGKITVKNPAKGKAVSFAAKVTDKKGNTSKVRIYSAYLGK
>NZ_CP016824.1|WP_003949215.1|3362913_3363948_-|iron-siderophore-ABC-transporter-substrate-binding-protein
MNDSAFSGKAARSSRRRKTATLAGAVAALLVGLTACGAGGDEQAEKPAEGKASSGAFPAKVATKFGEITIDEAPKRIVALGWGDAETALALGAQPVGASDWLPFGGEGVGPWAKGMYDKKPELIGTMEPEFEKIAALKPDLILDTKSSGDQTRYDTLSKIAPTVGVPKGGDMYMTSWEKQTEMVAGALGKKDEGAELIAETEKKFAAAAKEHPEFKDKTITVGSRTSEGFGAYVGGTGRVDFVKRLGFVNNPEIEKLAGDSFSVSVSKEKLDLLDADLTVMAPIGISAKEISDDPLYKAVPSVKDGRSIVFDDKDISQAFATDSVLSVGYALDKVVPLFSEKLK
>NZ_CP016824.1|WP_067413603.1|3375353_3385643_+|non-ribosomal-peptide-synthetase
MPSVPSDRPSAAFPLTAAQRGLWFAQRLDPDSPAYNVAEYVDVRGELDVRALRRAVRHVEEETEALRLTFGERDGVPWQRVRAEAGIEVPVSDVSGYADPHAEAVRRMTAELARPADLARGPLVRMALYRLAEGHHLFHQQVHHLAVDGYGAVLALARIAEVYTLLVTAPGEPVPVRPAPLGPVLADEEAYGNSEQRPRDGEFWAAYLDGAPAPAGLVPGAPGGPARRVRAVSRHLGAEEAAGLRAAAKRAGVAWPAFLMAALGVCLHRERGLGEVVLGLPVTGRRTPAARTTPAMLSQVLPMRLAVSPADRVADVARRASAEARQVLRHQRYPAQELRRERGLGVREAQAGPAVNVLAFDDTLSFGPSPATLHNLSVGPVEDLAVAAHASYGDGGLSLDLLGDADRYDEAGLARHHEAFCRMLAAFAEDPERPLGALPLVPAPEHARLVRLGTGPVAEGGPLPTLPEQFAAQAARTPWATAVVCGDERLTFAELDARVRALSVELAARGARPGERVAVGLERSADLVTALLAVLRSGAAYLPVDPSYPVDRLAYMLQDAAPVALVARPGTAVPHEGLELVDPAAVVPGGDGGVPEPPVPEPHDAAYVIYTSGSTGRPKGVVVEHRSLAQLLEHHRREAHALAAESLGRRLRVALTTAISFDASWDPVLWMLAGHELHLADDATRRDPEALAAFLAARRIDAVETTPSHLRQLLAAGLLAGDGHHPRVLALGGEPVDDALWAELRDHDELIVLNYYGPTETTVDAVTARVTGTAPAIGRPVAGARAYVLDSALHPMPLGTPGELYLSGEGVARGYAGRPGLTARRFLPDPYGPPGARMYRTGDLARWRPEGTLEFLGRTDDQVKIRGHRVETGEVEAALRALPGIADAAVAPAGPAGGERRLAAYLVPGPGGTDPAEVRDLLTAALPDHLVPALYAVLDRLPLTPNGKLDTARLPEATAPRSAGGAPRTEDEERMCAEFAACLGLDAVGRDDDFFRLGGHSLLATRLIGRVREAFGAEVAIRALFDHPTPAGLLTALDRTAPALPPLRAARPRPARVPLSPAQRRLWLLERLGGAGTAYHLPVGLRLAGPLDREALAAALGDVAERHESLRTVVAEDTDGPYQRVREPAPVPLAVAPLPRTGSPAPDPEPFDLAGEPPLRARLFTDGDRDHLLVLTFHHIAADGWSMLPLLGDLGDAYAARRAGRAPGLTPLPVQYADYALWQRELLGTPDAPTGRAARQLAHWRAALDGAPAESAPPADRPRPDRPSGRGGAVPVTVPAAVHRALLERAAASGTSPFMVLHAALAALLSRLGAGDDLVVGTPVAGRPDEALAGLVGFFVNTLALRTDTSGDPDLTTLLARVREADLAALAHQELPFEQVVSAVSPPRHPARHPLFQVMLALDNTPAPRATLDGLTVRRDTATGRTGAKFDLTWDLAERHTADGAPAGIGGELEYSEDLFDQATAERYAAQFTTLLTALLDRPDTPFTDLPFLGTRDRAAALDENGPTRPPATPDWTLTDVLATRAAADPGRTAVVDATGRLTFGELQDRAERLARRLAAAGVRPGDRVALALPRSAAALAALLGVLRAGAVHVPLDTTHPPARNTLVLRTAAPRLVLTTATTDEAVPATGHPRLVLAEDPDDWPATGPLPAPPRPEDAAYVLYTSGSTGRPKGVVVDHRALAHLYAHHREHLIGPAQGAAGGRQLRVALTAALTFDASWDPVLWMAAGHELHLVDDATRRDPEALTAHLRERAVDVVETTPSFAELLRSCGLFAPGHHRPRVLALGGEAVTEPLWEELAALPDVTAWNLYGPTEATVDALVAPVTAGTRPHLGRALPGARARVLDARLAPAAPGATGELYLTGPGLALGYERAPAATAARFLPDPYGPPGSRMYRTGDLVRRRAGRLEYLGRADGQAKVRGFRVETGEVEAALLRHPGVALAAATVRPGPDGSGRLLAWAVPAEGHHPTGGELRAHVATRLPSYMVPAAVVPVATLPLTVHGKTDFAALPDAPGPEAPADGTAVPRSAREEILCALFAECLGQPHVTRDDDFFALGGHSLLALGLIGRVRSAFGVELSVRTLFDATTPAALAARLDAAQPARPALRRAERPARPPLSPAQRRLWFLHGLDPADASYHIPVAVRLDGRLDRAALRDALADVTARHESLRTRVQDHEGEPCQAVLDPADARPALPTTPVTEAEVEAALREAAALPFDLAADLPLRAELFALGAERHVLLVTVHHIAADGWSMGPLAEDLAGAYAARTAGRVPQWAPLPVQYTDYTLWQADLLGDPDDAESVAGRQLAYWAEQLRGAPDEVPLPADRPRPARATGRGGTVDLTLPPATTEAVTRLARATGTSPFMVLHAALAALLTRTGAGEDLTVGTPVAGRTDEALHPLVGFFVNTLPLRVSTGGDPTFRALLARVKETDLAAYAHQDLPFERLVEEVRPARSLNRHPLFQTMLTLNNTRPPRLDLPHLAATLDGVASGGAKFDLSFSLREEDGTLTGTLEYSADRFEPGTARRIAAWFAHLTAAATAAPDAPVRQLPLHGPEEEERLLALGRGEPGGPVTGTVLDRFAATVAGARHGEPAVTAPDGTLTFAELDARVRHVAALTASAGVVPGDRVAVLLPRSTDSVAALLGVLAAGAVHVPLDPALPEARLAAVLADARPRLALATTATAPLLPAGQPRLLLDQAPPAAPAPTTPRPTPGDPAYLLHTSGSTGTPKGVLVGHRSLARLLDHHRRHLFAPAVRATGRARLAVALTAALTFDAAWDPLLWLLDGHHLHLVDDQIRRDPEALVDAVRTHRLDVLETTPSHTAHLLDAGLLADGAHHPAVLALGGEAVPAPLWTRLRAAPATRCLNLYGPTEATVDTLTADLADTPHPVLGTPVTGTRAHVLDAALRPTPPGVPGDLHLAGDSLALGYPGRPAETAARFVPDPYGPPGSRMYRTGDRAVRNADGSLVFAGRADGQVKIRGFRVETGEVAAVLEAHPQIAHAAVVPHEDPEAGTTLTAHLVPAPGTDPNPEEIRAHATRHLPAYMVPAGWTTLDRLPLTAHGKLDTAALPVPRALAVPTGGRVPRTPREDVLCTLFAEALGAERVTIDDDFFALGGHSLLATRLIGRIRATLGTDLSIRTLFEAPTVAALAGRLDSAADDDSLATLLPLRTTGSLPPLFCVHPAGGLAWPYAGLLPHLDPGQPLYGLQTPNLDGTAPFPESIEEMAATYAAEIRAVQPHGPYRLLGWSFGGNVVQEIAVQLQEAGEEVALLAILDAFPLAPQDDLDSAPRDAVFRALLANLGVGEEAAGGSGGVDAAAVREEFRRVGSPLGALEPATIDAMVDNFAGQARLMRRYTPRTFHGPVLFFTATEGRPADAFPHTLWDPYLTGPLHDTPVACAHAQLMSPDARATVGPVLAEALAALAEPAATPPAP
>NZ_CP016824.1|WP_067413605.1|3385719_3385929_+|MbtH-family-protein
MTNPFDDPRTHHRVLVNDEGQHALWPSFATVPAGWEAVFGPADQDACHAYVEEHWTDLPPRSARRTVAA
>NZ_CP016824.1|WP_067413608.1|3385925_3386948_+|ATP-binding-cassette-domain-containing-protein
MSRARPAPPGDGPALRAEGLTKRFGTKQALAGVDLDAPAGTVLGLLGPNGAGKTTTVRVLTTLLRPDTGRAWVAGHDVRTAPEAVRARLGLSGQYAAVDEKLTGRENLYLVARLYGTGRGPARRRAAELLDRFRLSEAADRPSGTYSGGMRRRLDLAGALVARPAVVVLDEPTTGLDPRGRADTWECVRELVATGTTVLLTTQYLEEADQLADSVAVIDHGRVIAQGTAAALKSRVGGERLTLTLPDPASRPGALDLLAPLTPHRPHLDPRTGVLTLPTDHGPATLEQALAALRHAGVPLGEVSLAPPTLDDVFLALTGQETSTAPVPGPVPTKEPAWQP
>NZ_CP016824.1|WP_003949235.1|3386935_3387736_+|ABC-transporter-permease
MAAVTRLARDATLIAWRNLLNLRRTPGSVVAALIQPVMFVLLLSYVFGGSLGGDAYRTYLMGGIFAQAVTFNAAFTALGLANDLDRGIVDRFRSLPMPPMAVILGRTLSDLTMSALTVAVTSLCGLFIGWRIAGTLPEAVLAYLLILLFAFAMSWVGATIGLTARSVEVAQSAGLIWLFPVTFLSSAFVPTATLPAALQPVADWNPVSATATALRTLFANPAPPTAPLRDTWPVTHALPYALLSTLAITAVFMGVAVRRFRAMGRG
>NZ_CP016824.1|WP_067413611.1|3387856_3388555_-|sensor-domain-containing-protein
MATADIPTADIPTACPLPHVSEQPAGAVRRGPLSAAAWREYGYVFTSFPLAIAGFVLAVTLFSLGAGLAVTVVGFPVLVALLAGARGLGAGERGRASGLLGLRTKAPAPVPAGGIKGRLADVAGWKAVLFQFVMFPWRIASFVVTLTLLLTGWVAALLPLYAWVFPTFVGWPGYQLFDWTDGAGVRHAYYLESFWQIGAASLVGIGLVLLTPVVVRALNGVDRAAVRGLLAG
>NZ_CP016824.1|WP_067413614.1|3388727_3389426_-|hypothetical-protein
MSADMAPPLPLDDSVERYAAELAAALRGPAGARERLVVEVRDGLAETVAAYEAAGVPAERAVREAVAEFGSVAEVAASCQRELTVAQARHTARALALTGPFLVACWWLVRGTGDGQGGVSGFAQQVAVQLSSAAAVAVVLAALALAATGAWGRWLPVAAERLPAAVAWTGTAASVAMAVTTLTLATAAFLAEQWPLTVLAGALAAASHAVVAGSARVCRECARLSSREPAVA
>NZ_CP016824.1|WP_003949238.1|3389422_3389776_-|PadR-family-transcriptional-regulator
MRHDAVRGHLDGLLLAVVEPGPLHGYAIITAVQERSGGALELRTGTIYPALNRLERVGLLRSDWEAVGQRKRRRYELTEAGRRQLAEERSAWRDFTRVIGAVLDPAPVPGAATGAAT
>NZ_CP016824.1|WP_067413616.1|3389906_3390368_+|DUF2269-family-protein
MAKLFLSLHVLAAILAIGPITVAASMFPRLARTAPTPETPALLHKICRSYAYVGAAVPVLGIATGAALGVLSDAWLIVSIVLTGVAAGVLVAVILPGQSELLEPLEGGEGAVAGEEERRAAGARLAMTTGVFNLLWAAVVVLMIVRPGSTTGA
>NZ_CP016824.1|WP_067413619.1|3390382_3391627_-|MFS-transporter
MPLALLALSVVAFAIGTTEFVSMGLLPQIADGVGVSVPQAGNLISAYALGVVVGAPLLTGLGAKIPHKKLLLLLAGLFVVGNVASALAPGFGTLFAARVLAGLPHGALFGVVAVVASRLVAPERAARAVSTMFLGLTVANIVGVPAGTALGQQFGWRSAYLAVAVIGLIALAALARLVPHQPRAEGAGIRHELKAMGNRHIAIGLATAVVGFGGCFAVYSYLVPMLTEVTGMASSSTTLVLALYGVGMTLGTLLAGPMTDRALRPTLYGGLAVMAVVLFAFYFAVQHTVTALVCVLLIGAMGSFITTPVQMLLMAKAEQAPTMAAASNHSAFNLANAGGAWLGGLVISAGWGWASPALVGASLAAAGLGLAVVGGVMDGGFGRGKRSTVVAGAGAKAGVKDEAEVQAAGVERAG
>NZ_CP016824.1|WP_067413623.1|3392010_3392679_+|DUF998-domain-containing-protein
MTGTFTTPGPLHPVATTQRSTARWLTTGGVVAGPLFLTAGLAQGLTREGFDFTRNAISQLALGGAGWVQTLSFVCTGALLVAGAAGLRRTLRRGPAGKWAPALVGVFGLSFWAAAVFPADAGAGFPAGSPDATVMSGHGAAHMAAGMIGYLALCAAFMVLARPLAARGLRGWAVASRVVPVAVLAGFMASAASVLAFTAGAGLGLLWLSAVMARLADAPGDR

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Crispr_ID: NZ_CP016824_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_18

3474365-3474475

Orphan

Consensus_repeat	Method
GATGTTTCACGTGAAACATC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP016824_18

>merge|NZ_CP016824|18|3474365-3474475|PILER-CR
GATGTTTCACGTGAAACATCCGGCTGCGGGCGCTAGCTCCGCGCTCGCGATGTTTCACGTGAAACATCATGGCTTCGGCGGCATTTCGCCTCATGTTTCACGTGAAACATC

>NZ_CP016824|18|2|3474365-3474475|PILER-CR
GATGTTTCACGTGAAACATC	CGGCTGCGGGCGCTAGCTCCGCGCTCGC
GATGTTTCACGTGAAACATC	ATGGCTTCGGCGGCATTTCGCCT
CATGTTTCACGTGAAACATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_003949310.1\|3464021_3465002_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NZ_CP016824.1\|WP_067413686.1\|3471730_3472645_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP016824.1\|WP_010644582.1\|3473352_3474336_-\|NAD(P)H-quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|176180
NZ_CP016824.1\|WP_003949326.1\|3482833_3483535_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380061
NZ_CP016824.1\|WP_003949323.1\|3479733_3480783_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NZ_CP016824.1\|WP_030772479.1\|3465004_3466354_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NZ_CP016824.1\|WP_008408593.1\|3469431_3471081_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP016824.1\|WP_067418107.1\|3466695_3467358_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP016824.1\|WP_067413680.1\|3462588_3464001_-\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NZ_CP016824.1\|WP_067418113.1\|3478300_3479734_-\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NZ_CP016824.1\|WP_030772463.1\|3475585_3477283_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NZ_CP016824.1\|WP_067413691.1\|3480779_3481976_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NZ_CP016824.1\|WP_003949315.1\|3471162_3471711_-\|bacterial-proteasome-activator-family-protein	unknown	unknown	gnl\|CDD\|378489
NZ_CP016824.1\|WP_067413694.1\|3483651_3484437_-\|TrmH-family-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|334162
NZ_CP016824.1\|WP_067413688.1\|3472783_3473170_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067418110.1\|3474482_3475589_-\|potassium-channel-family-protein	unknown	unknown	gnl\|CDD\|367001
NZ_CP016824.1\|WP_015507554.1\|3482180_3482645_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP016824.1\|WP_051722272.1\|3477279_3478197_-\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|133000
NZ_CP016824.1\|WP_067413697.1\|3484447_3485665_-\|HTTM-domain-containing-protein	unknown	unknown	gnl\|CDD\|214802
NZ_CP016824.1\|WP_067413683.1\|3467460_3469032_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_003949310.1\|3464021_3465002_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	1.98098e-153
NZ_CP016824.1\|WP_067413686.1\|3471730_3472645_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.58221e-07
NZ_CP016824.1\|WP_010644582.1\|3473352_3474336_-\|NAD(P)H-quinone-oxidoreductase	gnl\|CDD\|176180	cd05276, p53_inducible_oxidoreductase, PIG3 p53-inducible quinone oxidoreductase. PIG3 p53-inducible quinone oxidoreductase, a medium chain dehydrogenase/reductase family member, acts in the apoptotic pathway. PIG3 reduces ortho-quinones, but its apoptotic activity has been attributed to oxidative stress generation, since overexpression of PIG3 accumulates reactive oxygen species. PIG3 resembles the MDR family member quinone reductases, which catalyze the reduction of quinone to hydroxyquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
NZ_CP016824.1\|WP_003949326.1\|3482833_3483535_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	6.62392e-19
NZ_CP016824.1\|WP_003949323.1\|3479733_3480783_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	1.93426e-152
NZ_CP016824.1\|WP_030772479.1\|3465004_3466354_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	0
NZ_CP016824.1\|WP_008408593.1\|3469431_3471081_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.5719e-124
NZ_CP016824.1\|WP_067418107.1\|3466695_3467358_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.22515e-65
NZ_CP016824.1\|WP_067413680.1\|3462588_3464001_-\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	4.05302e-164
NZ_CP016824.1\|WP_067418113.1\|3478300_3479734_-\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	2.84909e-165
NZ_CP016824.1\|WP_030772463.1\|3475585_3477283_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	1.89082e-85
NZ_CP016824.1\|WP_067413691.1\|3480779_3481976_-\|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	3.50108e-164
NZ_CP016824.1\|WP_003949315.1\|3471162_3471711_-\|bacterial-proteasome-activator-family-protein	gnl\|CDD\|378489	pfam10759, DUF2587, Protein of unknown function (DUF2587). This is a bacterial family of proteins with no known function.	3.14859e-92
NZ_CP016824.1\|WP_067413694.1\|3483651_3484437_-\|TrmH-family-RNA-methyltransferase	gnl\|CDD\|334162	pfam00588, SpoU_methylase, SpoU rRNA Methylase family. This family of proteins probably use S-AdoMet.	5.49657e-32
NZ_CP016824.1\|WP_067418110.1\|3474482_3475589_-\|potassium-channel-family-protein	gnl\|CDD\|367001	pfam02254, TrkA_N, TrkA-N domain. This domain is found in a wide variety of proteins. These protein include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.	1.1114e-23
NZ_CP016824.1\|WP_015507554.1\|3482180_3482645_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	3.00939e-28
NZ_CP016824.1\|WP_051722272.1\|3477279_3478197_-\|NTP-transferase-domain-containing-protein	gnl\|CDD\|133000	cd02503, MobA, MobA catalyzes the formation of molybdopterin guanine dinucleotide. The prokaryotic enzyme molybdopterin-guanine dinucleotide biosynthesis protein A (MobA). All mononuclear molybdoenzymes bind molybdenum in complex with an organic cofactor termed molybdopterin (MPT). In many bacteria, including Escherichia coli, molybdopterin can be further modified by attachment of a GMP group to the terminal phosphate of molybdopterin to form molybdopterin guanine dinucleotide (MGD). This GMP attachment step is catalyzed by MobA, by linking a guanosine 5'-phosphate to MPT forming molybdopterin guanine dinucleotide. This reaction requires GTP, MgCl2, and the MPT form of the cofactor. It is a reaction unique to prokaryotes, and therefore may represent a potential drug target.	3.95709e-29
NZ_CP016824.1\|WP_067413697.1\|3484447_3485665_-\|HTTM-domain-containing-protein	gnl\|CDD\|214802	smart00752, HTTM, Horizontally Transferred TransMembrane Domain. Sequence analysis of vitamin K dependent gamma-carboxylases (VKGC) revealed the presence of a novel domain, HTTM (Horizontally Transferred TransMembrane) in its N-terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is more likely caused by horizontal gene transfer than by early invention. The conservation of VKGC catalytic sites indicates an enzymatic function also for the other family members.	2.44687e-28
NZ_CP016824.1\|WP_067413683.1\|3467460_3469032_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.39707e-117

>NZ_CP016824.1|WP_010644582.1|3473352_3474336_-|NAD(P)H-quinone-oxidoreductase
MHAITIPEPGGPEALVWAPVPDPVPGEGEVLVEVVAGAVNRADLLQRQGFYDPPPGASPYPGLECSGRIAAIGPGVSGWAVGDEVCALLSGGGYAEKVAVPAGQLLPVPAGVGLKTAAALPEVVCTVWSNVFMVSQLRPGETLLVHGGASGIGTMAIQLAKAVGARVAVTAGSPEKLRYCGELGADFLINYREQDFVEEIREVTAGAGADVILDIMGAKYLDRNVKALATNGRLAIIGMQGGTKAELDIATLLRKRGAVTATSLRGRPASEKAAIVAAVREHVWPLIDTGRVRPIVDREVPMRDAAAGHRVLEESSHIGKVLLVTGE
>NZ_CP016824.1|WP_067413688.1|3472783_3473170_-|hypothetical-protein
MHPAAVERDFHAQSNRLVGWGWFLLVVAFLAWGWGAWQVFVPPGADGTSETCAPPALADRPDPYSAATATSDEARHERNCAAARDWATPVSLLVVSVPAFAAGSGLFAAGWAMDRARRLTVDLEQARG
>NZ_CP016824.1|WP_067413686.1|3471730_3472645_-|hypothetical-protein
MGGRGTTAQARERGRLPGRPSDPAPTGGNDVITGVNLRVPARRTALPALLLTATALLAVPASPALAAPPSRPDSGAATLGEAYGPGGERPDRRDAAAPRENHGSGEATARTPAPEQPGGRRHDPGPHPGGPQDHRVHGMPDPPAPPTGPPPPDRTPASGVLPPLRPGAPAAPTGPPPAPHPETAPQRPAPSPSPSVPPSVAPRSPEHGRTPARSLPAAHAETAHRAAPDTRPVPREEATVPGPAEEDAVADDGTEAGEAGQGAGRQELARSSGRSLHVLPLGGGLIMVGLGLGLVFLALRVRRI
>NZ_CP016824.1|WP_003949315.1|3471162_3471711_-|bacterial-proteasome-activator-family-protein
MEMPRNERSSRSTENPQVLIVGQDGMALGGGDDETPEVPVTEMVEQPAKVMRIGSMIKQLLEEVRAAPLDEASRNRLKDIHSSSVKELEDGLAPELVEELERLSLPFTDEATPSDAELRIAQAQLVGWLEGLFHGIQTTLFAQQMAARAQLEQMRRALPPGVAPEEADGASPAAGRTGGPYL
>NZ_CP016824.1|WP_008408593.1|3469431_3471081_+|serine/threonine-protein-kinase
MSQDGAQGRYAGRAVAGGRYQLRDLLGEGGMASVHLAYDTVLDRQVAIKTLHTELGREAAFRERFRREAQSVAKLTHTNIVSVFDTGEDDLDGTATPYIVMEYVEGRPLGSVLDEAVSRQGAMPADQALKITADVLAALEISHEMGLVHRDIKPGNVMMTKRGVVKVMDFGIARAMQSGVTSMTQTGMVVGTPQYLSPEQALGRGVDARSDLYSVGIMLFQLVTGRLPFEADSPLAIAYAHVQEEPVAPSSVNRALPPAVDALVARALKKNPNERFPTAEAMRDECLRIAQSLQPAAPSIVPGQQTQSGAGVGSAVFPPVGQQPPSTGPVQTPYQPGPYGAQTPAPAQHHPAPTPTPGYGYPQQSGYGTPQPYGHQQAPATPPPYATVQQSGSGSTGGKRQMPLIVGSIVVALLAIGGLVTALALQKDDDSQAGGSGDPGSSQGEGKDGEKPGFRGPDLTKTMETEECTDPDESYNDPEKIRVPDFTFTNITFVKKCLQAAKWKYDTTSVDENAYGKDTVMRQSPKAGTEVDPDNMPQIQLDVSSGNPS
>NZ_CP016824.1|WP_067413683.1|3467460_3469032_-|serine/threonine-protein-kinase
MAQTQRAQGPSDPEATGGDMSDSHDAPELWGNGGLVGDGRYRLTRRLGRGGMAEVFAAEDVRLGRTVAVKLLRSDLAEDPVSKARFTREAQSVAGLNHHAVVAVYDSGEDRVGNSTVPYIVMEIVEGHTIRDLLVNAEAPGPEQALIIVSGVLEALAYSHQHGIVHRDIKPANVIITHAGAVKVMDFGIARALHGAQSTMTQTGMVMGTPQYLSPEQALGKAVDHRSDLYATGCLLYELLALRPPFTGETPLSVVYQHVQDQAVPPSEVSDAAPPELDGLVMRSLAKDPDDRFQSAEEMRGLVQYGLQMLQQQGGHTRTWNTGPVDLHEGGHTPAMGVGGMGGHGGLPHPDPGTMQQPMIRQPGVHDGGYEGGGRPGGSGRGRMWLIAVLAVLAIVGGVAFAMNGLNDDEGNKPPVKPSPSSTKDSSSPSASPSDEETDGETAPGDTGGNQQPYPPEQTGDSGWSNEQPTENTPESPANPTPTDEQPSQTEEPPPTEEEPPPTEEEPPGEDSPPAEGETTGGP
>NZ_CP016824.1|WP_067418107.1|3466695_3467358_+|response-regulator-transcription-factor
MRENGKITVFLLDDHEMVRRGVHEMLSAEDDIEVVGEAGTAAEALTRIPATRPDVAVLDVRLPDGSGVEVCREVRSRDESVKCLMLTSYADDEALFDAIMAGASGYVLKAIRGADLLDAVRQVAAGRSLLDPAATARVLERLRGHGTPGDDDRLGDLTEQERRILDLIGEGLTNRAIGERLHLAEKTIKNYVSALLAKLGMERRSQAAAYVARRHAERGE
>NZ_CP016824.1|WP_030772479.1|3465004_3466354_-|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MTVESSAARGTRRGGTETGGDAGRTARAAESPKPAKRATAKAPAKTAAKAPARKAPAKRTPAKATKAAKTAKTAGQAGPAAPATPAEPQLVQLLTPEGKRVADAEYDQYVADITPEELRGLYRDMVLTRRFDAEATSLQRQGELGLWASLLGQEAAQIGSGRATREDDWVFPTYREHGVAWCRGVDPANLLGMFRGVNHGGWDPNSNHFQLYTIVIGSQTLHATGYAMGITKDGADSAVIAYFGDGASSQGDVNEAFTFSAVYNAPVVFFCQNNQWAISEPTEKQTRVPLYQRASGFGFPGVRVDGNDVLACLAVTKAALARARRGEGPTLVEAFTYRMGAHTTSDDPTRYRSDDERESWEARDPIQRLRAHLEAEGHADEAFFTALEEESEALGRRVREAVRAMPDPDPMAMFEHTYADGHALVDEERAEFAAYQASFEDADVTGKAN
>NZ_CP016824.1|WP_003949310.1|3464021_3465002_-|alpha-ketoacid-dehydrogenase-subunit-beta
MATEKLALARALNESLRTALESDPKVLIMGEDVGKLGGVFRVTDGLQKDFGEDRVIDTPLAESGIVGTAIGLALRGYRPVVEIQFDGFVFPAYDQIVTQLAKMHARSLGTVKLPIVIRIPYGGGIGAVEHHSESPEALFAHVPGLKVVSPANAADGYWMLQQAIQSDDPVIFFEPKRRYWDKAEVDREAIPAPLHGAQVARAGTDLTLAAYGPMVKVCLAAADAAAEEGKSVEVLDLRSMSPVDFDAIQRSVERTRRLVVVHEAPVFLGTGAEIAARITERCFYHLEAPVLRVGGYHAPYPPARIEEEYLPGLDRVLDAVDRSLAF
>NZ_CP016824.1|WP_067413680.1|3462588_3464001_-|2-oxo-acid-dehydrogenase-subunit-E2
MTESAQAVREFKMPDVGEGLTEAEILKWYVQPGDTVTDGQVVCEVETAKAAVELPIPFDGTVRELRFAEGTTVDVGQVIISVATGGGAPAPEPEAAPAEAPAAEAESAEPQGRQPVLVGYGVSESSTKRRARRPAEQAPAAQAPAPEAPAPAPAPAPAAPVANGTPVSGADRPLAKPPVRKLAKDLGVDLATVVPTGEGGVVTREDVHAAAAPQAPAEPAPAPQAAPAPQAAAPAPDARETRIPVKGVRKATAQAMVGSAFTAPHVTEFVTVDVTRTMKLVEKMKADKDLAGVRVNPLLMVARALLVAIRRNPDVNAAWDEANQEIVRKHYVNLGIAAATPRGLIVPNIKDAQAKTLPELASALGELVSTAREGRTSPADMQGGTVTITNVGVFGVDTGTPILNPGESAILAFGAVKWQPWVHKGKVKPRQVTTLALSFDHRLVDGELGSKVLADVAAVLEHPKRLLTWT
>NZ_CP016824.1|WP_067418110.1|3474482_3475589_-|potassium-channel-family-protein
MKLPGQDAMARDADEHLVTHRVKLPHRVVERPLLQVAKRLSMALVVLLVTVFIVYLDRDGYGDNSDGSVDFLDAFYYATVTLSTTGYGDIVPVSDSARLINILAVTPLRVAFLIILVGTTLEVLTERTREEWRLNRWRSSLREHTVVVGFGTKGRSAIQTVIASGLSKDQIVIVDPNEKVIDAAAAEGFVGVVGDATRSDVLLRAEVQKARRIIIATQRDDTAVLVALTGRQLNRGANIVAAVREEENAPLLRQSGADAVITSASAAGRLLGLSVLSPSAGTVMEDLIQQGSGLDLVERPVIKAEVGKTPPETGDLVVSVLRGHRLLGYDDPAIGTLQLTDRVITIIHNKPGTAPVRPTAAGPKRPLP
>NZ_CP016824.1|WP_030772463.1|3475585_3477283_-|molybdopterin-molybdotransferase-MoeA
MSGSPAPDPDGFDSLLALVNDASARRTRDEPAAPYDQEADGRTGDAPQATGDDRTAAPRPSAGEPAGTPWPPEYGPEPPGRATPPAARSGGAPRPHETPDGETPGRASAAAASHGQCGARRHGSAVTGWAEAVRVAGRAGQAVRERTSGVRPPLELPPAEALGLVLARPLAALTDLPPFDTSAMDGWAVAGPGPWRVRPDGVLAGQSGEALADGEAVPIATGARVPRDVTAVIRSEHGRLDAHGGLHPEREVVHGQDIRPRAQECRTGDTLLPAGSAVTPAVLGLAAAAGYDTLAVHARPTVDLFVLGDELLTRGLPRDGLIRDALGPMLPHWLREAGAEVRTVERLGDRPDALAEAVAASEADLVVTTGGTAAGPVDFVHPTLERLGADLLVDGVAVRPGHPMLLARTAPGQHLVGLPGNPLAAVCGLLTLVVPLLRGLAGAPLRQGAAAGHTPGSRAVPDVYETRRVQLSSDPLVATAPPGPDAAAPTAVLDAPVQGHPSDTRLVPVRVDAGWARPLSFGGPAMLRGVATADALAVVVPGGAEAGHPVELLALPWAGGGGGFT
>NZ_CP016824.1|WP_051722272.1|3477279_3478197_-|NTP-transferase-domain-containing-protein
MSFGSGGSGVSGRGVGVFDAVVLAGGGARRLGGVDKPGLRVGGRALIDRVLAACGQARTTVVVAAPREVAREVVWAREEPAGGGPLAALAAGVAAAGGAEGAPAVVVVSADLPFLDEAAVRGLLARLAEGGADAVLARDAEGRDQPLVGAYLRAPLVRALAEIRAEEGELTGLPLRRLTSRLTLDHLAEEGGAPVSFDCDTWGDLAAARARIREHGHVLNEWILAAKEELGIDLDVDIRVLLDLARDAAHGVERPAAPLTTFLVGYAAGRAGGGPEAVAEAARKAAALAERWAAEVPPEPGAGTG
>NZ_CP016824.1|WP_067418113.1|3478300_3479734_-|2-oxo-acid-dehydrogenase-subunit-E2
MAEVKEFTLPDLGEGLTEAEVVRWLVEVGEVVAVDQPVVEVETAKAMVEVPCPYGGVVTARYGAEGEELAVGAPLLTVAVGADASAPAAAEGSGSGGADGVVAEADGADAAEDGGAGETSGAVLVGYGTGAPPARRRRVRPTPVPAAAAGQVNGVASGYGRHAVTPEVPVRAEAAEPVPGPVPVISPLVRRLARQNGVELRTLTGSGPDGLILRADVERAIGAAGAPAAAAEPSAAAASAPAADAGEVRIPLRGLRGVVADKMSRSRREIPEATCWVDVDATELLAARRAMNAAGGPDAPKISLLALLARICTAALARYPELNARVDTEAREIVRLERVHVGFAAQTDRGLVVPVVRDAHARSAESLSEELGRLTGAARDGSLTPGELTGSTFTLNNYGVFGVDGSTPIINPPEAAMLGVGRIVPKPWVYEGELAVRQVTQLSLTFDHRVCDGGVAGGFLRYVADCVEQPAVLLRGV
>NZ_CP016824.1|WP_003949323.1|3479733_3480783_-|alpha-ketoacid-dehydrogenase-subunit-beta
MTASAPETTGTARPARRAKAAKPATMGQAIGRALRDAMAEDPAVHVLGEDVGTLGGVFRITDGLAAEFGDDRCTDTPLAEAGILGTAVGMAMYGLRPVVEMQFDAFAYPSFEQLASHVAKMRNRTRGAMPLPITIRVPYGGGIGGVEHHSDSSEAYYVATPGLHVVTPATVEDAYGLLRAAIASDDPVVFMEPKRLYWSKSDWSPEAPAEVEPIGRAVVRRAGTDATLLTYGPSLPVCLEAAEAARAEGRQLEVVDLRSLVPFDDETVCASVRRTGRAVVVHEATGFGGPGAEIAARVTERCFHHLEAPVLRVTGFDIPYPPPMLERHHLPGVDRVLDAVERLQWEARS
>NZ_CP016824.1|WP_067413691.1|3480779_3481976_-|pyruvate-dehydrogenase-(acetyl-transferring)-E1-component-subunit-alpha
MSKKRQSAPVVDRRRPTGPEDVPEAAEHTVTPPAWRPRVDPGPLLPDESPFRLLGTEAAQEADPALLKRLHRELVLGRRYNTQATALTKQGRLAVYPSSTGQEACEVAAALVLEERDWLFPSYRDTLAAVARGLDPMEALTLLRGDWHTGYDPRAVRIAPLSTPLATQLPHAVGLAHAARLKGDDVVALAMVGDGGTSEGDFHEALNFAAVWQAPVVFLVQNNGFAISVPLDKQTAAPSLAHKAVGYGMPGRLVDGNDALAVHTVLAEAVARARAGGGPTLVEAITYRIDAHTNADDATRYRGAEEVEAWRAHDPVELIEGALRARGLADEAAFAAVREDAERFAASLRERMNADAELTPADLFDHVYAEPTPQLRGQAAQLRAELDAEAASHGEDLR
>NZ_CP016824.1|WP_015507554.1|3482180_3482645_+|Lrp/AsnC-family-transcriptional-regulator
MAEQPAPRPLDAVDRDILRLLQADGRASIRSVADTVHVSRANAYARINRLMEDGVIRGFGARVDHERAGQGACAYITLKIVQNSWRTIREELRQLPGAAHIALVSGDFDVLLMIHAADNRALRELVLTRLQSIPDVLSTRTLLVFEEEELSPEG
>NZ_CP016824.1|WP_003949326.1|3482833_3483535_-|TetR/AcrR-family-transcriptional-regulator
MTAHQGGGSPGAATAGQRGRGAGRAPRSGRDTYTPQTLLSVAVRVFNERGYDGTSMEHLSQAAGISKSSIYHHVSSKEELLRRAVSRAIDGLFAVLDEEGAVTGRPLERAQYVTRRTVEVLVAELPYVTLLLRVRGNTDTERWALERRREFDHRVAGLFAAAVREGELRGDVEVRMATRLLFGMINSVVEWYRPDGVRQGDGGSPYEEGPLGSGAEIADAVVRIAFSGLRAQG
>NZ_CP016824.1|WP_067413694.1|3483651_3484437_-|TrmH-family-RNA-methyltransferase
MDVYEALERWRGLAPEAGSGSAGAPRYVLLEGFHALKHALRFGAVVPVALCADRAAALQLAAELAPDLEGALAGLLVEVDAETLRGLVARPHPTGVAALAERPAPVAVEAALCGARRTPVVVLDQPRHLGNAGAVVRLAAGFGASGVVTTGPLDPWHPTVVRGGAGLHFATAVAPLEVPELPDGPLFALDPEGADIRGLTLPDDALLAFGSERHGLTAELRARADHLVALPMRPQVSSYNLATSVGMTLFHWASASGAAPA
>NZ_CP016824.1|WP_067413697.1|3484447_3485665_-|HTTM-domain-containing-protein
MKASLGRCARGVQLVTSRSLGPYQTAAVRIGLAGTWLLFLLREFPHRQLLYGPDGPWGWSMARRLIAGNDAFTLLMWSDGRLWFEAVYALAVLASALLLVGWRTRTMSVLFMVGVLSLQNRNIFVGDGGDNVVHLLAIYLVLTRCGQVWSLDARRAARAGAAGREPWADRAGPVLWAGGAAALAAVTVLGVAGWGWLLFFWTLLTGQALWWWLGRRAPDGQAYLLSDVVAHLVHNGALLVIMVETCLIYATAGWYKIQGSRWQDGTAVYYPLQLESFSPWPGISGMLAGQGLLVLVVTYGTVLTQVAFPFALLNRRAKNVLLALMMAEHLAIAVLLGLPFFSLAMIAADAVFLPTVFLLWAGARCARARAGVVRRARAVLGRGADGVPGDEEPAGPARKLPVRPS

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Crispr_ID: NZ_CP016824_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_19

3673997-3674085

Orphan

Consensus_repeat	Method
AGCCCGGCCGGCGTTTGAGGCCAGT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP016824_19

>merge|NZ_CP016824|19|3673997-3674085|CRISPRCasFinder
AGCCCGGCCGGCGTTTGAGGCCAGTCTTTGACCGGCACGGTCGAGACGGAGCCCGGCACACAACAGCCCGGCCGGCGCTTGAGGCCAGT

>NZ_CP016824|19|17|3673997-3674085|CRISPRCasFinder
AGCCCGGCCGGCGTTTGAGGCCAGT	CTTTGACCGGCACGGTCGAGACGGAGCCCGGCACACAAC
AGCCCGGCCGGCGCTTGAGGCCAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067413858.1\|3674429_3674999_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377369
NZ_CP016824.1\|WP_079165447.1\|3678918_3679827_+\|Dyp-type-peroxidase	unknown	unknown	gnl\|CDD\|367887
NZ_CP016824.1\|WP_067413861.1\|3675374_3675896_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NZ_CP016824.1\|WP_067413872.1\|3679839_3680184_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NZ_CP016824.1\|WP_067413853.1\|3671483_3671978_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067413846.1\|3664421_3665057_+\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
NZ_CP016824.1\|WP_003949514.1\|3675924_3676335_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319924
NZ_CP016824.1\|WP_008408649.1\|3669905_3670406_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|238198
NZ_CP016824.1\|WP_010644205.1\|3665138_3665828_-\|LytR-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379163
NZ_CP016824.1\|WP_067413851.1\|3668862_3669675_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187632
NZ_CP016824.1\|WP_067413848.1\|3666401_3667985_-\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349873
NZ_CP016824.1\|WP_003949522.1\|3685182_3686457_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|234856
NZ_CP016824.1\|WP_003949519.1\|3682223_3682556_+\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NZ_CP016824.1\|WP_067413878.1\|3683016_3685122_+\|DNA-polymerase-III-subunit-gamma-and-tau	unknown	unknown	gnl\|CDD\|236090
NZ_CP016824.1\|WP_067413875.1\|3680461_3682120_+\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NZ_CP016824.1\|WP_010644199.1\|3668205_3668799_-\|(Fe-S)-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|132296
NZ_CP016824.1\|WP_003949502.1\|3666005_3666302_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl\|CDD\|227737
NZ_CP016824.1\|WP_067413856.1\|3672050_3673433_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237057
NZ_CP016824.1\|WP_067413865.1\|3676388_3678779_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|223256
NZ_CP016824.1\|WP_059212889.1\|3670560_3671310_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067413858.1\|3674429_3674999_+\|hypothetical-protein	gnl\|CDD\|377369	pfam04471, Mrr_cat, Restriction endonuclease. Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA.	2.71429e-23
NZ_CP016824.1\|WP_079165447.1\|3678918_3679827_+\|Dyp-type-peroxidase	gnl\|CDD\|367887	pfam04261, Dyp_perox, Dyp-type peroxidase family. This family of dye-decolourising peroxidases lack a typical heme-binding region.	1.16982e-87
NZ_CP016824.1\|WP_067413872.1\|3679839_3680184_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	6.51183e-09
NZ_CP016824.1\|WP_067413846.1\|3664421_3665057_+\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	2.11158e-114
NZ_CP016824.1\|WP_003949514.1\|3675924_3676335_+\|VOC-family-protein	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	8.59344e-39
NZ_CP016824.1\|WP_008408649.1\|3669905_3670406_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|238198	cd00321, SO_family_Moco, Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Assimilatory NRs catalyze the reduction of nitrate to nitrite which is subsequently converted to NH4+ by nitrite reductase. Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate.	0.00144819
NZ_CP016824.1\|WP_010644205.1\|3665138_3665828_-\|LytR-C-terminal-domain-containing-protein	gnl\|CDD\|379163	pfam13399, LytR_C, LytR cell envelope-related transcriptional attenuator. This family appears at the C-terminus of members of the LytR_cpsA_psr, pfam03816, family.	2.88619e-09
NZ_CP016824.1\|WP_067413861.1\|3675374_3675896_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.44189e-26
NZ_CP016824.1\|WP_067413848.1\|3666401_3667985_-\|M28-family-peptidase	gnl\|CDD\|349873	cd03876, M28_SGAP_like, M28 Zn-peptidase Streptomyces griseus aminopeptidase and similar proteins. Peptidase family M28; Streptomyces griseus Aminopeptidase (SGAP, Leucine aminopeptidase (LAP), aminopeptidase S, Mername-AA022 peptidase) subfamily. SGAP is a di-zinc exopeptidase with high preference towards large hydrophobic amino-terminal residues, with Leu being the most efficiently cleaved. It can accommodate all except Pro and Glu residues in the P1' position. It is a monomeric (30 kDa), calcium-activated and calcium-stabilized enzyme; its activation by calcium correlates with substrate specificity and it has thermal stability only in the presence of calcium. Although SGAP contains a calcium binding site, it is not conserved in many members of this subfamily. SGAP is present in the extracellular fluid of S. griseus cultures.	9.13329e-115
NZ_CP016824.1\|WP_003949522.1\|3685182_3686457_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NZ_CP016824.1\|WP_003949519.1\|3682223_3682556_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	9.07104e-14
NZ_CP016824.1\|WP_067413878.1\|3683016_3685122_+\|DNA-polymerase-III-subunit-gamma-and-tau	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0
NZ_CP016824.1\|WP_067413875.1\|3680461_3682120_+\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	1.14437e-116
NZ_CP016824.1\|WP_010644199.1\|3668205_3668799_-\|(Fe-S)-cluster-assembly-protein	gnl\|CDD\|132296	TIGR03252, TIGR03252, uncharacterized HhH-GPD family protein. This model describes a small, well-conserved bacterial protein family. Its sequence largely consists of a domain, HhH-GPD, found in a variety of related base excision DNA repair enzymes (see pfam00730). [DNA metabolism, DNA replication, recombination, and repair].	1.64658e-94
NZ_CP016824.1\|WP_067413851.1\|3668862_3669675_-\|SDR-family-oxidoreductase	gnl\|CDD\|187632	cd05374, 17beta-HSD-like_SDR_c, 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. 17beta-hydroxysteroid dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.36206e-80
NZ_CP016824.1\|WP_003949502.1\|3666005_3666302_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl\|CDD\|227737	COG5450, COG5450, Transcription regulator of the Arc/MetJ class [Transcription].	4.34799e-08
NZ_CP016824.1\|WP_067413856.1\|3672050_3673433_+\|hypothetical-protein	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	2.96268e-06
NZ_CP016824.1\|WP_067413865.1\|3676388_3678779_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|223256	COG0178, UvrA, Excinuclease ATPase subunit [DNA replication, recombination, and repair].	0
NZ_CP016824.1\|WP_059212889.1\|3670560_3671310_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	5.10697e-20

>NZ_CP016824.1|WP_067413856.1|3672050_3673433_+|hypothetical-protein
MEQGQRWWGPVGRGTEPPPPPPSPSPPRPRGNRRPKTPPGPRPAAPPAPSRAPRPVTLRRALLLGAAPLVLALAAVLLTPGRWEAALGLLAVYAATCAAAAYRPGRARPGGTPDRPGATTEHTGPPALPSPRTTEPRPAAKAPPAELPASLPAPRPAHDPAVTTFGLLLQAHPFVPAPGSPYQELAAWSRALEAYDEAGRAGAEQVPGILAEGRAALTTLDRLLGLDTPDAAPDCFFDARHGPAAATVRWAPPHGAARTVEVCRADAARLADAEATTGPAHAPPAYDTCHGNGALRLTLRPPGDAAPLLLAFTCDTPRTVEVIAGSGRRGRVRLLRRQGPVGAVLPVPRGTATAAGLALDIRASGPWTATLLATAHTRDLGPSAEGTGPDILTKETRSRLVLLHHQGPGPFRVRRLYRDFRPGPVLAEGTGTARVELGVPGACLLQVEASGAWRLVDTAA
>NZ_CP016824.1|WP_067413853.1|3671483_3671978_+|hypothetical-protein
MADVEPDTDARRDTGAHPAAEAVRFGPGPVLRLEITDHRDALFDGAWWPYSHRVHIEIPRLVGGLAGHWDPVTRVGVDLETWGALPTRLVIDGRVVRIDGYPVADDTALVTRDDHALFSLLVVPPEAAPEAAVAAMARALDPRNTATAGTILTETGVRPGHPRR
>NZ_CP016824.1|WP_059212889.1|3670560_3671310_+|sulfite-exporter-TauE/SafE-family-protein
MTLWEAVAVLLAGFAGGALNTAVGSGTLVTFPVLLATGLPPVTATVSNALGLIPGSLSGAYAYRRELAGQRRLLLPLCASAAAGGLVGAGLLMVLPPGVFATVVPVLVGLALLLIAVQPLLTRALRGRLTRPGGGLPLRISLGLASVYGGYFSAGQGILYVALSGALLDAPLQRINALKNVLVAQVNAVAAGFFLIAADIDWPAALLIAAGATAGAPFGARAAQRLRPVALRVLILTVGTAGLLHMTLS
>NZ_CP016824.1|WP_008408649.1|3669905_3670406_+|molybdopterin-dependent-oxidoreductase
MGGASGTARTGRCVELCGETGEPARLTVAELAGGWPEQRAEVVFDCATSGPRHHTFTGPLLRDVLLGALPGAVPATRKDRAGRLLVIAGADGHRAVLAWAEVDEEFRYAPVLLAVRLDGALLDAPHLVVPADRCGARYVSAVTGVRLVRPGLPVAAGEERLVSGAG
>NZ_CP016824.1|WP_067413851.1|3668862_3669675_-|SDR-family-oxidoreductase
MEQAGRDGRTALVTGASSGIGAAVAALLVARGYRVLGTSRDPERVAEPVPGVTYLALDLADDASVRACAEAAGPVDVLVNNAGESQSGPLEELPPEALERLFRVNVLGAVRLTQLLLPAMRERRAGRIVMVGSMLASFPLAYRSSYVASKAALKGFADAARRELAPYGIRMSTVEPGSIATGISERRTEYVAADSPYRAEYATMLRHLNANEAAGIPAEKVAATVLRAVEDERPRPLYAVGSNAPFVFALRRLLPRAAVLRIVARRHGLG
>NZ_CP016824.1|WP_010644199.1|3668205_3668799_-|(Fe-S)-cluster-assembly-protein
MEKTLRLAQEPRADALLSRSPLADLVGMLLDQQVPMEWAFSGPYTIARRMGADDLDAHEIAAYDPDEFAALLSAKPAVHRYPGSMARRVQQLCQYLVDHYDGDAEALWQDVADGEELLGRLKALPGYGPQKAQIFLALLGKQLGVRPPGWREAAGVYGQEHAYRSVADITGPESLARVRAHKQEMKRAAKAARDDGS
>NZ_CP016824.1|WP_067413848.1|3666401_3667985_-|M28-family-peptidase
MAVVAATALATPLLLGAAPGHGHGHGPGHGHKPSTPGKDAAALARELVKESSAHDAHRHLRKLQSIADRNDGHRAAGSPGHEASAAYIEKLMKKAGYKVTRQTFSFTYTETLAQKLSVVEPGQRDVAVHAMTYTASTPEGGLQAALVDTPADADGTPGCTSTDYSAEVEGAVALIERGGCSFAEKQAAAAEAGAVGAIIYNNTEGALSGTLGEAGAGRVPTGGVTQAEGKALAADAAKGAKVSLEIRQLQEERETDNLLAETRGGNADRTVMLGAHLDSVTEGAGINDNGSGSAGLVEVALNLADATNQNRPGKHGKAKEPRNKVRFAWWSAEENGLLGSEHYVGKLSEKQRGQIPAYLNFDMIASPNAAQFVFDGDDSDGVGEGPGPEGSAQIERDITAFLDRQGKPHEGTDFDGRSDYGPFVEAGIPAGGTFTGAEGLKTKEQAKRYGGTAGEAYDPCYHSACDDLKNISMKAFDTNIDVIAHAVGTYAHDLSSLGKPVKQKAAPEVQRHQGEGQAQGHHHGLTE
>NZ_CP016824.1|WP_003949502.1|3666005_3666302_-|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MIFKRIGNGRPYPDHGRESTRQWADVAPRPVRLDQLVTTKGQLDLETLLAEDSTFYGDLFAHVVKWRGDLYLEDGLHRAVRAALQQRQVLHARVLELD
>NZ_CP016824.1|WP_010644205.1|3665138_3665828_-|LytR-C-terminal-domain-containing-protein
MGGKYRITGDKYPRMRRTGGRRKLVLAATGGVLALGLVGWGTFQLVDVFTGGSTATAAGGRNCPAPATSASPAKATPLPAPGRIKVNVLNATERSGLAKQTADALKKRGFAIGEVGNATEEYDKKVKGTVLLLGAADAVDGAFPVLATQVGGAKQKVEAPVKGEPAKADAAEAEGEADGAAKGPRKPNEVDLIIGDGFKKLAPEAAATGALKALNAPKPSPSPTAAGRC
>NZ_CP016824.1|WP_067413846.1|3664421_3665057_+|uracil-phosphoribosyltransferase
MRIHVVDHPLVAHKLTTLRDKRTDSPTFRRLADELVTLLAYEATRDVRTEQVDIDTPVARTTGVKLSYPRPLVVPILRAGLGMLDGMVRLLPTAEVGFLGMIRDESTLQASTYAARMPEDLTGRQVYVLDPMLATGGTLVAAIKEMIRRGADDITAVVLLAPPEGVEIMERELEGTPVTVVTASVDERLNEHGYIVPGLGDAGDRMYGQAD
>NZ_CP016824.1|WP_067413858.1|3674429_3674999_+|hypothetical-protein
MAAATGASATALWWLHHTDRLPRRGKPRPHEPTALRAASLAEVDALSWREFEHHVAALCRRDGCRDVVVTGGAGDLGADVTATLPDGRRLVIQCKHYAPHRYVPSGDMQKFLGTAWLHHRADVAVFAATCPFGKAALALAAEHRITAVHRDLLGLWNSGTPLTALLAVGGAGQGDAAHRRRWRETYGRG
>NZ_CP016824.1|WP_067413861.1|3675374_3675896_+|helix-turn-helix-transcriptional-regulator
MSTSPPPAPHLGDLALLRRVRDRIDREYARPLDVEALARGVNMSAGHLSRQFRLAYGEPPYSYLMTRRIERAMALLRRGDLSVTEVCFAVGCSSLGTFSSRFTELVGVPPSVFRERQDLAGQNIEGMPACVAKQVTRPVRRAKPPRGSAPGGEAAGGGAEPVRNREARTGRPA
>NZ_CP016824.1|WP_003949514.1|3675924_3676335_+|VOC-family-protein
MHLTVHASFLPHNDPEAALAFYRDLLGLEVRDDVGYGGMRWITVGPPGGAGSAIVLLPPGADPGVTEDERRTIDAMMAKGTYGGILLATPDLTTTFEKLVAGDAEIVQEPTDQPYGVRDCAVRDPAGNLIRIQERR
>NZ_CP016824.1|WP_067413865.1|3676388_3678779_+|excinuclease-ABC-subunit-UvrA
MTRATRQDAPSAAPHAADHHDLIRVHGARENNLKDVSIEIPKRRLTVFTGVSGSGKSSLVFDTIAAESQRLINETYSAFLQGFMPTLARPEVDVLEGLTTAIIVDQQRLGADPRSTVGTATDANAMLRILFSRLGDPHIGSPNAYSFNVPSVRAHGAITVERGNAKTVRQSFTRTGGMCPHCEGRGTVSDIDLTQLYDDSKSISEGAFTIPGWKSDSWWTVRLYADSGFLDPDKPIRDFTEQEMRDFLYREPTKVKVEGTNLTYEGLIPKIQKSFLSKDREGMQPHIRAFVDRAVTFTACPECGGTRLSEAARSSRIGELNIADACALQITDLADWVATLDEPSVAPLLAALRHTLDSFVEIGLGYLSLDRPAGTLSGGEAQRVKMIRHLGSSLTDVTYVFDEPTIGLHPHDIERMNGLLLRLRDKGNTVLVVEHKPETIAIADHVVDLGPGGGTGGGTISFEGTVAGLRASDTLTGRHLDDRATLKKDVREPTGTLEIRGADRHNLQDVDVDIPLGVLTVVTGVAGSGKSSLIHGSIPGSDEVVSVDQSPIRGSRRSNPATYTGLLDPIRKAFAKANGVKPALFSANSEGACPNCKGAGVVYTDLGMMAGVSATCEECDGKRFEASVLEHHLGGKDISEVLAMPVTEAEEFFREGEARTPAAHRVLTRLADVGLGYLTLGQPLTTLSGGERQRLKLATHMADKGGTYVLDEPTTGLHLADVDQLLALLDRLVDSGKSVIVIEHHQAVMAHADWIIDLGPGAGHDGGRVVFEGTPAELTEKRGTVTGEHLAAYVEG
>NZ_CP016824.1|WP_079165447.1|3678918_3679827_+|Dyp-type-peroxidase
MDAPLSAAAGFLVLVVKDGEEAAATVRSVVAGTDDLIKDITIRANGAMFTCNVGISHHGWPRLTGKPLPKELRLFREIKGEKHTAVATPGDLLYHLRAASPDLIVEFEKILLEAFGDSVTAVDDVTGFRYFDGRDLLEFADGTANPDGAALPAATLVGDEDPAYAGGSYVVVQKYLHDLSAWRAQTTGTQEEIIGRTKFDNVEKPDATEGQKSHKTLCTIQDADGEHDILRDNTPFAHPGTGEYGTYFIGYSRHLWVTEKMLERMFLGDPPPLHDRILDYSRAVTGVTFFCPARAFLAALGD
>NZ_CP016824.1|WP_067413872.1|3679839_3680184_-|nuclear-transport-factor-2-family-protein
MASTEQVAERFHAALTAADADGLREVLAEEVTFEGPVATASGVAECVAGLVEMGKMISGDQVEVRLVDGGNVLTWSTVRAGGGPGRPTVTWLRVDGERITAIRTVFDARGTGGR
>NZ_CP016824.1|WP_067413875.1|3680461_3682120_+|SulP-family-inorganic-anion-transporter
MRSLLPTRADFAAMTRDPRRDLLAGLTVAIVALPLALGFGVSSGLGAEAGLATAVVAGALAALFGGSSLQVSGPTGAMTVVLVPIVAQYGPGGVLTVGLMAGVLLLALAVLKAGRYMRYVPAPVVEGFTLGIACVIGLQQVPNALGVAAPEGDSVLMVTWRAVEEFVRAPNWTASGLALGVAAVMLLGARWRPAVPFSIVAVVAATAAAQLFHLDGAAPIGALPSGLPAPSLDFLELSALGSLLAPALAVAALAALESLLSATVADGMTTGQKHDPDRELFGQGVANLAAPLFGGVPATAAIARTAVNVRSGAGSRLAALTHAAVLAVIVFAAAPLVSKIPLAALAGVLIATAVRMVEAGALRAMVRSTRSDAVVLVLTAVATLVLDLVLAVVIGLVVAGALALRAVAVQARIDRTDAPSEPPAVHSDAEHAPPSEHIATYRVDGPLFFAGAHRVLLELSEVAGVRVVILRLARVTTMDATGALALKEAVEDLGRRGIAVLACGIRPAHRRTLASVGALDALRDREYATGSEALAAAHAHLGRTGPLPAGTA
>NZ_CP016824.1|WP_003949519.1|3682223_3682556_+|helix-turn-helix-transcriptional-regulator
MSTPLYQLKAEFFKTLGHPVRIRVLELLSRREHAVSELLSDIGVEPAHLSQQLAVLRRANLVVPRREGSAVHYSLTNPDVAELLRVARTILSGVLTDQAELLAGLRADES
>NZ_CP016824.1|WP_067413878.1|3683016_3685122_+|DNA-polymerase-III-subunit-gamma-and-tau
MSSLALYRRYRPESFAEVIGQEHVTDPLQQALRNNRVNHAYLFSGPRGCGKTTSARILARCLNCEQGPTPDPCGTCQSCQDLARNGPGSIDVIEIDAASHGGVDDARDLREKAFFGPASSRYKIYIIDEAHMVTSAGFNALLKVVEEPPEHLKFIFATTEPEKVIGTIRSRTHHYPFRLVPPGTLREYLAEVCGKEGSRVEDGVLPLVVRAGAGSVRDSMSVMDQLLAGAGEDGVTYAMATALLGYTDGSLLDSVVDAFAAGDGAAAFEVVDRVVEGGNDPRRFVADLLERLRDLVILAAVPDAAEKGLIDAPADLVERMQAQASVFGAAELSRAADLVNEGLTEMRGATSPRPQLELICARVLLPAAYDDERSTLARLERLERSGPPAQAAAPLAPPAYAPAQPQVPQAPPAPAPTPAPQQSAPPAAAPDAPPADAAPARPGAWPGSAPPGSGAPAPAARRPGGWPTAGAGGGPAPQQAEPQGPGRPQGQPQPQAAPATPPPGAVDARALWPNVLEAVKNRRRFTWILLSQNAHVAGFDGTTLQLGFLNAGARDNFASSGSEDVLKQALGEEFQVNWKIETVIDASGGQGPATPPGGGGGGGWGQAPAQPRPAAPAPAPAPAPPQPGPAAPPAPAPASQTPPAPQREQRPPAPEPPRRTTSIEDDIPEEDDPDLDESALSGHDLIMRELGATVVEEYTNE
>NZ_CP016824.1|WP_003949522.1|3685182_3686457_+|phosphoribosylamine--glycine-ligase
MKVLVIGSGAREHALCRSLSLDPDVTALYCAPGNAGIAEVAELHPVDALDGAAVARLATGLGADLVVVGPEAPLVAGVADAVRVAGIDCFGPSAEAARLEGSKAFAKDVMAGAGVPTARSYVCTTAAEIDTALDAFGAPYVVKDDGLAAGKGVVVTEDVDEAREHALNCVSAGGGRVVVEEFLDGPEVSLFAVTDGRTVVPLQPAQDFKRALDGDQGPNTGGMGAYSPLPWADPKLVDEVLETVLQPTVDELRRRGTPFSGLLYAGLAITSRGIRVIEFNARFGDPETQVVLARLRTPLAGVLRAAADGTLAALPPLRWSEEAAVTVVVASHNYPGTPRTGDPVEGLAEVAELDAPAAYVLHAGTRQDGDAVLSAGGRVLSVTATGADLTEARDRAYTAVARIRLDGSQHRSDIAARVAVEERG

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Crispr_ID: NZ_CP016824_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_20

3778519-3778793

Orphan

Consensus_repeat	Method
CGGAACANCCCCGCCCTCGCGNGGANCACNC	CRT
GGAACACCCCCGCCCTCGCGGGGACCACC	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP016824_20

>merge|NZ_CP016824|20|3778519-3778793|CRT,CRISPRCasFinder
CGGAACATCCCCGCCCTCGCGAGGATCACTCGAGCAGGACCCGGTGCGCCCGGTCGGAGAGCGGAACATCCCCGCCCTCGCGAGGATCACTCGAGCAGGACCCGGTGCGCCCGGTCGGAGAGCGGAACACCCCCGCCCTCGCGGGGACCACCCGGTCAGCCGCGCCGACCTCACCGGCAGCGCTGGAACACCTCCGCCCTCGCGGGGACCACCTCCGGCGCGGTGCCATGGGCATCGGCGTCCTCGGAACACCCCCGCCCTCGCGGGGACCACCC

>NZ_CP016824|20|1|3778519-3778793|CRT
CGGAACATCCCCGCCCTCGCGAGGATCACTC	GAGCAGGACCCGGTGCGCCCGGTCGGAGAG
CGGAACATCCCCGCCCTCGCGAGGATCACTC	GAGCAGGACCCGGTGCGCCCGGTCGGAGAG
CGGAACACCCCCGCCCTCGCGGGGACCACCC	GGTCAGCCGCGCCGACCTCACCGGCAGCGC
TGGAACACCTCCGCCCTCGCGGGGACCACCT	CCGGCGCGGTGCCATGGGCATCGGCGTCCT
CGGAACACCCCCGCCCTCGCGGGGACCACCC

>NZ_CP016824|20|18|3778520-3778792|CRISPRCasFinder
GGAACATCCCCGCCCTCGCGAGGATCACT	CGAGCAGGACCCGGTGCGCCCGGTCGGAGAGC
GGAACATCCCCGCCCTCGCGAGGATCACT	CGAGCAGGACCCGGTGCGCCCGGTCGGAGAGC
GGAACACCCCCGCCCTCGCGGGGACCACC	CGGTCAGCCGCGCCGACCTCACCGGCAGCGCT
GGAACACCTCCGCCCTCGCGGGGACCACC	TCCGGCGCGGTGCCATGGGCATCGGCGTCCTC
GGAACACCCCCGCCCTCGCGGGGACCACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067413985.1\|3778926_3779586_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP016824.1\|WP_067413979.1\|3775615_3776056_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP016824.1\|WP_067418129.1\|3777777_3778320_+\|flavoprotein	unknown	unknown	gnl\|CDD\|235513
NZ_CP016824.1\|WP_067413965.1\|3770282_3771863_-\|phosphate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270371
NZ_CP016824.1\|WP_067413973.1\|3773846_3774812_-\|ATP-grasp-ribosomal-peptide-maturase	unknown	unknown	gnl\|CDD\|275040
NZ_CP016824.1\|WP_067413999.1\|3785767_3786718_+\|alpha-L-glutamate-ligase	unknown	unknown	gnl\|CDD\|275040
NZ_CP016824.1\|WP_067413982.1\|3776344_3777697_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003949599.1\|3785569_3785764_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373048
NZ_CP016824.1\|WP_067413994.1\|3784441_3785383_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP016824.1\|WP_003949581.1\|3772092_3772647_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_031178660.1\|3781263_3781839_+\|heme-binding-protein	unknown	unknown	gnl\|CDD\|377163
NZ_CP016824.1\|WP_067413988.1\|3779594_3780878_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP016824.1\|WP_018893691.1\|3781888_3782509_+\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|223738
NZ_CP016824.1\|WP_003949585.1\|3775206_3775425_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067413992.1\|3783513_3784206_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067413976.1\|3774819_3775077_-\|putative-ATP-grasp-modified-RiPP	unknown	unknown	gnl\|CDD\|275039
NZ_CP016824.1\|WP_067413967.1\|3772659_3773850_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|275041
NZ_CP016824.1\|WP_003949596.1\|3783129_3783510_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP016824.1\|WP_003949595.1\|3782550_3782958_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|223329
NZ_CP016824.1\|WP_079165348.1\|3775421_3775619_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067413985.1\|3778926_3779586_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.72559e-69
NZ_CP016824.1\|WP_067413979.1\|3775615_3776056_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	6.98606e-16
NZ_CP016824.1\|WP_067418129.1\|3777777_3778320_+\|flavoprotein	gnl\|CDD\|235513	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated.	1.31496e-06
NZ_CP016824.1\|WP_067413988.1\|3779594_3780878_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.6597e-51
NZ_CP016824.1\|WP_067413973.1\|3773846_3774812_-\|ATP-grasp-ribosomal-peptide-maturase	gnl\|CDD\|275040	TIGR04187, conserved_hypothetical_protein, ATP-grasp ribosomal peptide maturase, SAV_5884 family. Members of this protein family are ATP-grasp ligase family enzymes that regularly occur in a contexts with a methyltransferase and a putative ribosomally translated post-translationally modified peptide precursor. Because of this conserved gene neighborhood and close sequence similarity to ATP-grasp enzymes from microviridin/marinostatin biosynthesis cassettes, this enzyme is suggested also to serve as a peptide maturase.	5.68023e-134
NZ_CP016824.1\|WP_067413999.1\|3785767_3786718_+\|alpha-L-glutamate-ligase	gnl\|CDD\|275040	TIGR04187, conserved_hypothetical_protein, ATP-grasp ribosomal peptide maturase, SAV_5884 family. Members of this protein family are ATP-grasp ligase family enzymes that regularly occur in a contexts with a methyltransferase and a putative ribosomally translated post-translationally modified peptide precursor. Because of this conserved gene neighborhood and close sequence similarity to ATP-grasp enzymes from microviridin/marinostatin biosynthesis cassettes, this enzyme is suggested also to serve as a peptide maturase.	1.75751e-99
NZ_CP016824.1\|WP_003949599.1\|3785569_3785764_+\|hypothetical-protein	gnl\|CDD\|373048	pfam14404, Strep_pep, Ribosomally synthesized peptide in Streptomyces species. A ribosomally synthesized peptide related to microviridin and marinostatin, usually in the gene neighborhood of one or more RimK-like ATP-grasp. The gene-context suggests that it is further modified by the ATP-grasp. The peptide is predicted to function in a defensive or developmental role, or as an antibiotic.	1.56854e-25
NZ_CP016824.1\|WP_067413994.1\|3784441_3785383_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.68122e-08
NZ_CP016824.1\|WP_067413965.1\|3770282_3771863_-\|phosphate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270371	cd13653, PBP2_phosphate_like_1, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.84239e-42
NZ_CP016824.1\|WP_031178660.1\|3781263_3781839_+\|heme-binding-protein	gnl\|CDD\|377163	pfam03928, Haem_degrading, Haem-degrading. Haem_bdg is a bacterial protein that is up-regulated in response to haemin- and peroxide-based oxidative stress. It interacts with the SenS/SenR two-component signal transduction system. Iron binds to surface-exposed lysine residues of an octomeric assembly of the protein.	1.1607e-22
NZ_CP016824.1\|WP_018893691.1\|3781888_3782509_+\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|223738	COG0666, Arp, FOG: Ankyrin repeat [General function prediction only].	7.2411e-14
NZ_CP016824.1\|WP_003949596.1\|3783129_3783510_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	6.12361e-31
NZ_CP016824.1\|WP_067413976.1\|3774819_3775077_-\|putative-ATP-grasp-modified-RiPP	gnl\|CDD\|275039	TIGR04186, conserved_hypothetical_protein, putative ATP-grasp target RiPP. A RiPP is a ribosomally produced, post-translationally modified peptide. This family regularly occurs next to ATP-grasp enzymes related to those of microviridin maturation and next to a methyltransferase.	6.08228e-21
NZ_CP016824.1\|WP_067413967.1\|3772659_3773850_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|275041	TIGR04188, conserved_hypothetical_protein, methyltransferase, ATP-grasp peptide maturase system. Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).	3.11331e-169
NZ_CP016824.1\|WP_003949595.1\|3782550_3782958_-\|RidA-family-protein	gnl\|CDD\|223329	COG0251, TdcF, Putative translation initiation inhibitor, yjgF family [Translation, ribosomal structure and biogenesis].	3.61696e-22

>NZ_CP016824.1|WP_067418129.1|3777777_3778320_+|flavoprotein
MTRPVLYLIATAAGPAQHVDVGIRAAQASGWDTCLFLTPTAATWWADSMVELESLTGHPVRHRYTLPGQSGGLPKADAMLVAPLTTTSACKWAAGVTDTVALGVPAEAVHLGVPVVAAPFWSTALGAQPAVGRAVETLRGQGVRVVFTEGEPHLPKRGDAAGFGWEEALGEVERAVGGGR
>NZ_CP016824.1|WP_067413982.1|3776344_3777697_+|hypothetical-protein
MATRKRTPNPALADLLDQARWTRTQLAQQVNRLGPQAGLQLTYDRTAVAHWIAGTPPKPEVRPLILEALSARLGRPVTHEEAGLVPASSAEGARSVDTVEELIDLGRADMDPSRRKLLATATLFSAALSVPAFQQTARAADGTASPAKAISRIGPSQVTAVRAMTERIADILDELGAGHARPMAAAFLVNTVGPWLRADATEPVRRDMLAAASDLTYLTGWMAMYEKAHGLGQTYYTKALKLADEAGDHATYCRTLRGMSLQASSLGHGRMALELADSAAEAAPSAGPRLVAFLRGQQAHAASMVGDRNQAHSRLREAESALSRADNRRDAVGGYDQTAYLFHVSHVLMEEGDHAGSIKALKHSIRVQAPQERQGRVHAYATLAQRQLRHGHLDASCDSWGRFLDEYEHVASVRGDEHFATMRRDLAPHAKVRAVKELAGRAREVSAAKA
>NZ_CP016824.1|WP_067413979.1|3775615_3776056_-|ATP-binding-protein
MAGTASDRHPSQPHLEPAPTGHPAYTETLPCPPESAPAARRLIRQALGAWALDGLADDACLVAGEMVANACRHTRSPVIRVSVTRLDGTTVEIAVTDRSRVLPARKPAAPDALDGRGLLLVDAVAARWGADPQRWGKRVWAEVRAA
>NZ_CP016824.1|WP_079165348.1|3775421_3775619_-|hypothetical-protein
MNAYERPDTYERLGAPGCRQCEELRDEEVQARREFDHSRAVDCRVLLRRHPHHDSPAPPPPPAPR
>NZ_CP016824.1|WP_003949585.1|3775206_3775425_-|hypothetical-protein
MTEPPARLPHPRRHWTPGTCWRCEAREVPVLWLGPVQTSSGTGSFTACDPCVRRLETYVRRELALRDTAPAF
>NZ_CP016824.1|WP_067413976.1|3774819_3775077_-|putative-ATP-grasp-modified-RiPP
MRITNPRTARPWGAARLAPYPTTTHVPYCRTEIDPLTQLGVALDRHGRVVEMGKHGTSTGTETNTTTSSDGQNNDQGHDQDGDKD
>NZ_CP016824.1|WP_067413973.1|3773846_3774812_-|ATP-grasp-ribosomal-peptide-maturase
MTEQGPVLVATETDDATADMVIGELNRRSVPVVRFNPADLQDGTLTVSARFGTCPGVPVTGQVRTPSRTADLTKVRAVYWRRPDWPAYARLGADDARYAAAQARHGLGGTLYSLAGPRWVNHPLRNAAADHKPAQLALAQRLGLPVPATLITNDPDEARDFLHTHGQVIHKPLRWTPYQRDGVPVTGWAAPVTADEIDEGVRVTPHLFQARVPKVADLRVLVVGRRLFAVRIDSGLLDWRRDYSALTYSVATLPAPVSAALLAFLDHCHLPTGSFDLALDRAGTPWFLELNPNGQWAWLEHATGLPMAATLAALLTEGATP
>NZ_CP016824.1|WP_067413967.1|3772659_3773850_-|methyltransferase-domain-containing-protein
MTDPTTTERHALAARLAHSGALRTPAWRQAVESVPREAFLHPGVFLPEPRGRWRPFLADRSPEAEWTRLAYSDQSLVTQLDGCLTPDQATTPEPVPGVPTSSSTEPALVLRMLESLEVEEGQEVLEIGTGTGYSTALLCHRLGEDNVTTVDVDPGVARRADDALESIGVSTWTVTGDGLLGHPPRAPYDRVIATCAVRRVPYTWVRQTRPGGVILTTLGSWPHGGGLAKVTVGADGTAEGRIVGPVSFMHARAQAQPPVTGDLAARAAYADCEREVRVPPTVLEERTPAFLAQLTVPDAQLVHARTAGGEQRTYLFAPDRESFAEFVPDALASAGWTVRQGGPVRLWDQVEEVLLAWRDAGSPGIDAVRLRVTETAHHYWLDGASAPSLRWEHALR
>NZ_CP016824.1|WP_003949581.1|3772092_3772647_+|hypothetical-protein
MTMTDPYTCPSCSCGQNARTVAVGPPQLEEERPETARERVNRKWNEVLQETRVAQTGISILFGFLLSVAFTSLFGELAGLDRGIYVVTVVLAALATASLIAPVSLHRFLSGLRVKDELVDAAARLMVCGMVLLALTICGTLLLILRTAVPSLLAEVLVGGVMVWFGLCWYVLPWMIRRRAGRRR
>NZ_CP016824.1|WP_067413965.1|3770282_3771863_-|phosphate-ABC-transporter-substrate-binding-protein
MEWVNAENVIAVGTFAVASSIAFGQWWYERMVPRRRRIGYRVQLDTAIGDDDGTGGGNTRLGLFDEADGMDEASVVLLRIENDGALSVSIGDYTSGGLHGMTATFDGREVHGVAVTVGPGSGALMSHFTPAHGLEYSGSSLRIPRVPLNKGEYFKLLVLLSGGTVGSKVTVSGGVQDGDVHPNESLTPDEKPPVFSRPARLTSMAFLVGIALLAGLIVTGGERPPPMGCATGSLEVTGSTAFAPVAEELAEAYMEQCPGSRITVAAHGSTTGLRELAERGAAAKDGAPALVALSDGPAPEGQETGDAGQDEGEAGEGGGLAGTRLAVSVFTLLAHADVPVRNLTLADLRRIYAGEVTDWREVGADRSLPIVLVGRGAASGTRDVLQRRLLEGAFEPPASSRDCSRKDNPKASVVRCELDTTDQVIATVARVPGALGYSELRTTSTLEGVRRLSLDGRRPSLDGAGHDAYPYREIEYAYTYGRPPADSLAAGFLAFTTRGPGQDVVRTHGHLPCGTPEGLRVCGAAD
>NZ_CP016824.1|WP_067413985.1|3778926_3779586_-|response-regulator-transcription-factor
MPPPTDEPPPPAPVRLLLCDDHAVVRAGLRALLSSAPGIEVVAEAGSGEEALALTTLHHPDLVLMDLQLGEGIDGVETTRRLTTLPDHTPYVLVLTTYDTDADITRAVEAGATGYLLKAERPEELFTAIRAAASGRTALSPPVAQRVMTHLRNPQPELTPRERDILRHLTQGLGNREIARALFISEATVKTHLGRIYQKLGVETRAGAVAVGKERRLLG
>NZ_CP016824.1|WP_067413988.1|3779594_3780878_-|sensor-histidine-kinase
MRHPDDHPQPPSTSPGSPGSPASGTFAPGAQTRDDRLLSALLTTAFVVLLAGALLRYVLKHGDSDRLPWIVGLSVVLAVVQVAGQARPGSRRAGRVRLAVVVACWVVVVLLAPSFAWCAVPLIHTALRLLPTRSAVALVTALATLVVLAELRLADGFDPNHLLLPPVVAALATGVFVYLTREATRRQHLIDDLVRTRRELAATERREGTLAERQRLSREIHDSLAQGLSSQNMLLQAADRQWDTDPQAARTHLRTAASIAAHGLTEARRLVHDLAPADLAEGAGLAQALATLAARESRDGLTVRFHAEGPDTHLPDQVASALLRTAQGALANIREHSGARTAALTLTCLDDTVALDVADDGRGFPAPEPGGTRDPLGDPDPLRGHGLPAIRARLRQLGGTLAIESTPGEGAVLTATIPLTPATPPAS
>NZ_CP016824.1|WP_031178660.1|3781263_3781839_+|heme-binding-protein
MSFSTAFRSTRTRVLTGSAVVVALGAGVFGTVSASADTAPAAKPAAAQAAADASGRNVTQTSHLTIAAATKAAQAALDAAGKEKQKVSVAVVDRDGRALVTLRGDGAGPQSYEAAQEKAFTAVSWNAPTSELVKRLDSAPTLKDIPGTLFLAGGAPVTVKGAPVAGIGVAGAPSGDLDEKFAKAGVTALFR
>NZ_CP016824.1|WP_018893691.1|3781888_3782509_+|ankyrin-repeat-domain-containing-protein
MSRQEQKKAEARLIEAAGAGDAEGVKAALAAGARTEVSDASGRTPLLLASLGDHVAAARALVEAGADPDAQDDRDDSAWLVTGVTGSVEMMRTLLPAEPDQTLRNRFGGTALIPAAERGHVPYIRAALREASMEVDHVNGLGWTALLEAVILGDGGADHQETVRLLLAAGATPDLADRDGVTPREHAERRGFDRMAELLRKAEAAG
>NZ_CP016824.1|WP_003949595.1|3782550_3782958_-|RidA-family-protein
MAITLVDPEGLPKVGAYRQVAVATGSRLVFVAGQVAWDADGATVGAGDLAAQVERCYLNVHTALTAAGGTFADVAKLTVYVVDWTPDKMPHFLDGVARATARLGETPAAPGTLVGVAALDVPEHLVEVEATAVLD
>NZ_CP016824.1|WP_003949596.1|3783129_3783510_+|helix-turn-helix-transcriptional-regulator
MVTKQLSGTPEDADLSRADSLAREIFSEVANKWALLIIDALGESTVRFSEIRDRVEGISHKMLTQNLRMLERNGLVERYVHPTVPPRVDYTLTEPGLALRETTHLMCAWTQRYLGHIEGARGRFEG
>NZ_CP016824.1|WP_067413992.1|3783513_3784206_-|hypothetical-protein
MTEQRQQDNRPPPPSRRSQRRQTVAELRSQGRAGPGLRDILPGFLGMVLVTAGPVIGLAWLYRAYGLGALLLGALLLAAATLIGVPWRRAVVRRRGGRYTPAELAVLDDHGLAVAAERILRRDGWHVLPMPDDGRPRLYARDRRDRRLDVSFRPVEGGPDAAEPPGGPATLREPGGPADDRVIRVVISMGTYSPAEIEWASRPGGDHLVDGRQLQQWASGTSLDALGLLT
>NZ_CP016824.1|WP_067413994.1|3784441_3785383_-|helix-turn-helix-transcriptional-regulator
MPAPKSVDPTASLAALLGARIRRLRRAKGWSQTELAAKGATSQGRLAQMELGRETPSQTVCQLLDQALDADGELLALWAHIERTPYPDWSRAFMRFEQRATRMRKYMAATVPGLLQTESYVRALLAAARPSVGGALESLVRARLERRLLLTGDSPPYFWAILDESVLRRPIGQPEVMREQLTYLLHMQETERVSLQVLPFSAGVHPALGGSVTVLSFDRRPDVAYLESSHSGELIDDPEAAAGYGLAFDQLHAQALSPHASAAMIRNVLEGSYGVTRVSRRRRRSVAQEQLQQHAGWGLRRGPRRPARPGSDT
>NZ_CP016824.1|WP_003949599.1|3785569_3785764_+|hypothetical-protein
MTMTPFALQYARPQTGEPAAPYAFDQAEQVNVLAGGGYAAEDTALLARLGSTASTAGSKTHWDD
>NZ_CP016824.1|WP_067413999.1|3785767_3786718_+|alpha-L-glutamate-ligase
MTVLVLTCEEDVTADAVVLQLRRRGVPVLRLDPAEFPGRVDLAVRVTPDGQVTGHLATPGGRVALEEIRSVWVRRPGTPGAHVSAEQRAWITLECERALWGALRATGARWMNDPDALERSRHKLWQLATAARAGLRVPDTLVTTDPDEAARFQKTYADAGSGLVVKSVTGRHPQNPPLTLPTAAVPPDADFTGVAACATCLQQRVPKRTDLRLTVVGDRYFPAYVTPRTPTLDWRFLPADASTWMAGEVDGALRAAVRRYLQEAQLAYAAFDFAIDEQGDPWFLEANAGGQFLFAEIETGMPMTEAIAAWLAIRRE

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Crispr_ID: NZ_CP016824_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_21

3967929-3968068

Orphan

Consensus_repeat	Method
TGGCCTCAAGCGCCGGCCGGGCT	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP016824_21

>merge|NZ_CP016824|21|3967929-3968068|CRISPRCasFinder
TGACCTCAAGCGCCGGCCCGGCTCTTTGGCCTCAAGCGCCGGCCGGGCTGGTTTTGGCCTCAAGCGCCGGCCGGGCTGGTTTGGGGGTGCGGTGGGATCGACCGCGCCGGTCACCGATGGCCTCAAACGCCGGCCGGGCT

>NZ_CP016824|21|19|3967929-3968068|CRISPRCasFinder
TGACCTCAAGCGCCGGCCCGGCT	CTTTGGCCTCAAGCGCCGGCCGGGCTGGTTT
TGGCCTCAAGCGCCGGCCGGGCT	GGTTTGGGGGTGCGGTGGGATCGACCGCGCCGGTCACCGA
TGGCCTCAAACGCCGGCCGGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067414311.1\|3959201_3959870_+\|uridine-kinase	unknown	unknown	gnl\|CDD\|235825
NZ_CP016824.1\|WP_003949801.1\|3973905_3974316_+\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NZ_CP016824.1\|WP_008410337.1\|3963580_3964261_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP016824.1\|WP_003949791.1\|3961412_3962093_-\|phosphate-signaling-complex-protein-PhoU	unknown	unknown	gnl\|CDD\|273990
NZ_CP016824.1\|WP_067414314.1\|3964348_3965038_-\|DUF461-domain-containing-protein	unknown	unknown	gnl\|CDD\|223029
NZ_CP016824.1\|WP_067414328.1\|3972589_3973855_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NZ_CP016824.1\|WP_003949789.1\|3960424_3960748_-\|multidrug-transporter	unknown	unknown	gnl\|CDD\|224987
NZ_CP016824.1\|WP_067414320.1\|3968568_3969183_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP016824.1\|WP_008409794.1\|3974406_3975807_+\|cysteine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234705
NZ_CP016824.1\|WP_003949803.1\|3975947_3976886_+\|23S-rRNA-(guanosine(2251)-2'-O)-methyltransferase-RlmB	unknown	unknown	gnl\|CDD\|223640
NZ_CP016824.1\|WP_067414326.1\|3970826_3972593_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224094
NZ_CP016824.1\|WP_075986682.1\|3965575_3965812_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_026235414.1\|3959871_3960435_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225767
NZ_CP016824.1\|WP_018471324.1\|3978766_3979789_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NZ_CP016824.1\|WP_003949795.1\|3965773_3966256_+\|CarD-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224248
NZ_CP016824.1\|WP_067414331.1\|3977061_3978654_+\|DoxX-family-membrane-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP016824.1\|WP_003949796.1\|3966628_3967426_+\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|234670
NZ_CP016824.1\|WP_008410335.1\|3962279_3963584_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|274368
NZ_CP016824.1\|WP_067414323.1\|3969241_3970792_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173855
NZ_CP016824.1\|WP_067414317.1\|3968153_3968432_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067414311.1\|3959201_3959870_+\|uridine-kinase	gnl\|CDD\|235825	PRK06547, PRK06547, hypothetical protein; Provisional.	8.33635e-15
NZ_CP016824.1\|WP_003949801.1\|3973905_3974316_+\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	6.47275e-41
NZ_CP016824.1\|WP_008410337.1\|3963580_3964261_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.50602e-94
NZ_CP016824.1\|WP_003949791.1\|3961412_3962093_-\|phosphate-signaling-complex-protein-PhoU	gnl\|CDD\|273990	TIGR02135, Uncharacterized_protein, phosphate transport system regulatory protein PhoU. This model describes PhoU, a regulatory protein of unknown mechanism for high-affinity phosphate ABC transporter systems. The protein consists of two copies of the domain described by pfam01895. Deletion of PhoU activates constitutive expression of the phosphate ABC transporter and allows phosphate transport, but causes a growth defect and so likely has some second function. [Regulatory functions, Other, Transport and binding proteins, Anions].	1.69432e-59
NZ_CP016824.1\|WP_067414314.1\|3964348_3965038_-\|DUF461-domain-containing-protein	gnl\|CDD\|223029	PHA03264, PHA03264, envelope glycoprotein D; Provisional.	0.000299833
NZ_CP016824.1\|WP_018471324.1\|3978766_3979789_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	6.13745e-72
NZ_CP016824.1\|WP_003949789.1\|3960424_3960748_-\|multidrug-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	2.05166e-20
NZ_CP016824.1\|WP_067414320.1\|3968568_3969183_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	6.22555e-14
NZ_CP016824.1\|WP_008409794.1\|3974406_3975807_+\|cysteine--tRNA-ligase	gnl\|CDD\|234705	PRK00260, cysS, cysteinyl-tRNA synthetase; Validated.	0
NZ_CP016824.1\|WP_003949803.1\|3975947_3976886_+\|23S-rRNA-(guanosine(2251)-2'-O)-methyltransferase-RlmB	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	3.12594e-77
NZ_CP016824.1\|WP_067414326.1\|3970826_3972593_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.03023e-43
NZ_CP016824.1\|WP_067414328.1\|3972589_3973855_+\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.29178e-56
NZ_CP016824.1\|WP_026235414.1\|3959871_3960435_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|225767	COG3226, COG3226, Uncharacterized protein conserved in bacteria [Function unknown].	1.15335e-15
NZ_CP016824.1\|WP_003949795.1\|3965773_3966256_+\|CarD-family-transcriptional-regulator	gnl\|CDD\|224248	COG1329, COG1329, Transcriptional regulators, similar to M. xanthus CarD [Transcription].	1.13617e-68
NZ_CP016824.1\|WP_067414331.1\|3977061_3978654_+\|DoxX-family-membrane-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	9.10933e-08
NZ_CP016824.1\|WP_003949796.1\|3966628_3967426_+\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	gnl\|CDD\|234670	PRK00155, ispD, D-ribitol-5-phosphate cytidylyltransferase.	8.35528e-79
NZ_CP016824.1\|WP_067414323.1\|3969241_3970792_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173855	cd08490, PBP2_NikA_DppA_OppA_like_3, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	7.44902e-152
NZ_CP016824.1\|WP_008410335.1\|3962279_3963584_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	1.2459e-81

>NZ_CP016824.1|WP_003949796.1|3966628_3967426_+|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase
MTDETQAPRTAVVIPAAGRGVRLGPGTPKALRTLHGTPMLVHAVRAMAASRAVSLVVVVAPSDGVAEVRAMVDDHLHPTEAPSFAPARAGGGDETDIVVVAGGETRQESVRRGLDALPADVTTVLVHDAARPLVPVDIVDGVVAAVRGGAPAVVPGLPLSDTVKEVGALAEGATGPGEPVVATPERARLRAVQTPQGFDREALDRAHRQGPVQGEGATDDAGLCERLGLPVVVVPGHEEAFKVTRPLDLVLAEAVLARRRANDGY
>NZ_CP016824.1|WP_003949795.1|3965773_3966256_+|CarD-family-transcriptional-regulator
MTFKVGDTVVYPHHGAALIEAIETRQIKGVDKNYLVLKVAQGDLTVRVPADNAELVGVRDVVGQDGLDRVFEVLRAPYAEEPTNWSRRYKANLEKLASGDVIRVAEVVRDLWRRERERGLSAGEKRMLAKARQILVSELALAENTNEDKAEALLDEVLAS
>NZ_CP016824.1|WP_075986682.1|3965575_3965812_-|hypothetical-protein
MGIDHGVANLERHVTGTPSVAIKGNTRIGALEWRFRRSGHISGLDNNNANVLRRACGTRYSQVGAALRGKGNAYVTGS
>NZ_CP016824.1|WP_067414314.1|3964348_3965038_-|DUF461-domain-containing-protein
MSSSLRRGALAAAAIAFSIASLASCAAGNNAETHQINPDNARATVGDIMVQNAVVVTQPDRESTGPAIVAATIFNNGTKDQTLDSVVVDGVNKKAELTAAQGNGKLTIPAGGRLIVGGEDNASAVLPSSRTAVLDGNAQAITFTFSRTGDVKLNTLVVPATSYFEKWGPSEMPSAPASGSPSPDTSASPGEGSETPADETGGPTEGAEGAEGAQGAQGEAADGASHAGH
>NZ_CP016824.1|WP_008410337.1|3963580_3964261_+|response-regulator-transcription-factor
MTRVLVVEDEESFSDALSYMLRKEGFEVAIAATGPEGLDEFERNGADLVLLDLMLPGLPGTEVCRQLRGRSNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFSSRELVARIRAVLRRRGEPEEAVPQALEAGPVRMDVDRHVVTVSGGKVDLPLKEFDLLEMLLRNAGRVLTRMQLIDRVWGADYVGDTKTLDVHVKRLRAKIEPDPGAPRYLVTVRGLGYKFEP
>NZ_CP016824.1|WP_008410335.1|3962279_3963584_+|two-component-sensor-histidine-kinase
MDVNTAVAAVAAIAGVCTGVIAMLAFRWSERELRRPTRSSLHSTPVLPPGVDTVLSALRSSAVVLDEGDGVVKASSAAYALGLVRGGKLAVEPMLKMARDTRRDGEIRQAELDLPRRGAGRGDGLAVSARVAPLGSRLVLLLVEDLTEARRIEAVRRDFVANVSHELKTPVGALSLLSEAVRDAADDPEAVERFAGRMEIEATRLTSLVQELIDLSRVQNDDPMEDAEPVDVDELIAEAMDRSRQAAAHKQITMSWGGDIDLFVWGSRGALVGALGNLVENAVNYSPPRTRVGVAARRVAEPDGTYIDITVTDQGIGISEKDRERIFERFYRVDPARSRATGGTGLGLAIVKHVAASHGGEVTVWSSEGQGSTFTLRLPEAGATRDRRTRPKTRPRPATGGPDASGATAARTTGDVPVPLTAPPSVLPAPEVLP
>NZ_CP016824.1|WP_003949791.1|3961412_3962093_-|phosphate-signaling-complex-protein-PhoU
MRDAYHEELDSIGDSLVEMARLVGSAIGRATTAILDADLNLAESVIAGDQKIDDLQHDLEARAIALLARQQPVATDLRIVVTSLRMSADLERSGDLAKHVAKQARLRYPESPVPRDLHATLLEMGQLAQRLMAKAAEVIITKDVDLALQLETDDDEMDLLHRTLFQHLMDDRWKHGVETAVDVTLLGRYYERFADHAVSVANRVVYLVTGEHADGIQTPGVPVEGV
>NZ_CP016824.1|WP_003949789.1|3960424_3960748_-|multidrug-transporter
MTWVLLACAILAEVTATISLRLSEGFSKIAPSVVVVVGYVTAFTLLALVLKRGMAIGVAYGIWAAAGVALVALIGAAFLGDSLTPVQYGGLVLVAAGVVALEAGGAH
>NZ_CP016824.1|WP_026235414.1|3959871_3960435_-|TetR-family-transcriptional-regulator
MPTEPVADGRRARGEETRRRLLDATVRVIERDGVAGVTHRAVAAEAGVPKSVASYHYPAVDDLLTAALRDSSDAYARDLAALLPEGYGLGDLAAHLTACQEENRSRALAEYELYLQAARRPALRPAAARWTAVLAELAAPFTTDPATVATLTATLDGLFLQALLRDEPVDAGRVEAAMRVVIEGAAR
>NZ_CP016824.1|WP_067414311.1|3959201_3959870_+|uridine-kinase
MADPTPGESGPYALFDVAAYAARVRAGAGGRGGHYLLGVDGPGASGKSTLAGQLARHLPQAHIVHVDDFHLPSADRTRTGAPVGPRFDLRRLREQVLAPAARGEPLAYERYDWGSDRLGERVEVPARTPLIVEGVYSTHLAARPYYHHRLFCRAARALRLRRGLERDGAAAEPLWTGEWMPAEDDYVAAERPDLAADTVLSSDHETPGDDGPRYWHTRRTAR
>NZ_CP016824.1|WP_067414317.1|3968153_3968432_-|hypothetical-protein
MDSDDERLLRGRVYGHDPTAPESGPLPGHHYAELVGGPLDGLLLDITTVPPEARPEGAALPTALSTHGPEGRSLYQPRPTTPSRWDWQGDLR
>NZ_CP016824.1|WP_067414320.1|3968568_3969183_+|GNAT-family-N-acetyltransferase
MAVVAGVEAGVRERAEEAGRDAYGVRTASEADVPGARAVMLDTVYRDLRSGYVPRWHADIIDPAAAYLEPERCTLLVVERDGEIVATGAVRDRGPATPPNPRWVADRFPSGSTAQLCRIYVRPEHRRHGLARRLVRELCDFVVRAGGYERVYLHTDPSVPGAEAFWRATAEEVCDERALPGGGQGIVHFEVPVAGLGRPAAAPA
>NZ_CP016824.1|WP_067414323.1|3969241_3970792_+|ABC-transporter-substrate-binding-protein
MSSQPSQPSKYSVRRRPLLALGAAALLVPVAACGGSTDGGASGGGDQRLRAVMAFPPAQAMSPYGDDAVTLSRLSVVEGLTRIDEEGAAKPALATKWQRDGAKGWEFTLRDARFQDGDAVDAEAVVRSLAAAQDASPKPRVLSEVRLTAEAEGKRTVRITTDEADPLLPQRLANPSLAILSQAAYAKGEKGGKVNPAGHATGPYTLTEVNGAVSAKLDRNDTYWGRKAKAPGVDVKFVADGTARANALRTGTADIAEYVPVAQTSLLDEKQIHEVPTARTNTLYLNTENGVFADPAVRAAARSAIDSKALVDGVYEGRADTARGLLGPGVPWAADARKEPEGRAKAASKAEVAKTKEIVLATYTNRPELPEVASAVQQQLQARGFTVKQYVRDYAQMEADALAGKYDAFIQARNTLLDTADPVSYLGSDFTCEGSFNIAQLCDKGVDEAVAKAAGADGQDARHTAEMAAEAKILGADAAVPLVHERFVQGFDSGKVDGVALDPMERRLITADTRLR
>NZ_CP016824.1|WP_067414326.1|3970826_3972593_+|ABC-transporter-permease-subunit
MKHLAGRALTLLAVLALIGLLPWLTTTDPALTILHARYSDRQPPPEVLDAIRAETGLDGGPAHVLGGWAGGLLHGDLGTSWVSGQPVGPDVTAALATSLSLMGVSLAVALLLALVLSARTLRRGARREATTTRAGVLAAVLAALPEFLLAAVLATVLAVHLGWFPALGWGTPAQAVLPALAMGVPAGALLGRLLDDALPAAFAEPWAKAATAAGLPPRRIARHALRRTLRGLLPQGGLVVVGLTGSAVAVETLFAVPGLGSTALAGALAQDLPVLQAAVLMLLLTGLAAALAVRLLSRVLLGPALTDRALPALVAPRLPARKGVAAGAVVLAVVFCAVLVAGLLRDPLHVDAAARLLPPSAAHPFGTDALGRDVLARLGHGAARTVLLAFAVAAAALLLGLAAGFLRAGALTETVNALPAVLAGLLTAAVAGPGPWGAAAAVAAVAWAPLAAHTEALYVQERAAPHLAAARSLGAGRAHLLRRHLLPAVLPPVTRHALLRVPALALALAALGFLGLGTQPPAPEWGRMLSENMPYVERAPWAVLAPAAALAVLGALAVLLAAAVRGRTGADTATATAPTAPAAREAAA
>NZ_CP016824.1|WP_067414328.1|3972589_3973855_+|MFS-transporter
MSTGTGLRPATSSLREITGLPPYLRLLAGTQFAFNTGFYAVLPYLAGHLGDGLGMAGWLVGLVLGLRTFSQQGLFVVGGALTDRYGPRPVVLAGCLLRIAGFAWLALAGSTATVVAAVVLTGFAAALFSPAVESETAREAVRRELADGTVRARTLAVFSAAGQAGAFLGPLLGSLLLAAGGEWGFRAACAAGVAVFVAVLAGHAVLMPRRAAVHRDRPRGGVRHLARNPRFLVLCLTYSTWLLAYNQLYLALPAEVERATGSQAALGWLFALSSLLVVTAQIPLTRHAAVRLAPRTALAGGLALVAAGFALVPVTPGGPGGLLPGAVLVTLLTCGQMLLVPAARGLVPDLVDGRHLGLATGALSSLSGLAVLGGSAASGLLLQAPAPVLWGALAAVPLAGGVAARLLPSGRGGGEAGRAAG
>NZ_CP016824.1|WP_003949801.1|3973905_3974316_+|PPOX-class-F420-dependent-oxidoreductase
MSDTAQLSDALKQKLDTPVFITVATIQPDGSPQLSPVWVKRDGNDVLFSTTVDRRKTKNLRRDPRVTVQVQPFDEPYTYAEIRGRATVTEEGGQELIDELSRKYTGKSYAEFNPASGQDAARVVVRVTPDKVVGRL
>NZ_CP016824.1|WP_008409794.1|3974406_3975807_+|cysteine--tRNA-ligase
MTIRLYDTSARQIRDFAPLTPGCVSIYLCGATVQSAPHIGHIRSGLNFDILRRWFAYRGYDVTFIRNVTDIDDKIIKKSAEQERPWWAIGYENERAFNNGYDALGCLPPTYEPRATGHVPEMIEMMRGLIERGHAYEADGNVYFDVRSFPEYLELSNQDLDELRQPSGEGETGKRDPRDFAMWKAAKPGEPSWETPWGRGRPGWHLECSAMAHKYLGSAFDIHGGGLDLVFPHHENEIAQAKAYGDDFATYWVHNAWVTMAGEKMSKSLGNSVLVSEMVKHWRPIVLRYYLGTPHYRSMIEYSEEALREAESAFARIEGFMQRVTEKAGETPEPATEVPPAFAEAMDDDLGVPQALAVIHTTVRQGNSALAADDKEAAVARLAEVRAMLGVLGLDPYDPHWAGEADRGEDLHGAVDTLVRLVLDQREAARTRKDWATADAIRDQLQQSGLVIEDSPTGPRWTLGPR
>NZ_CP016824.1|WP_003949803.1|3975947_3976886_+|23S-rRNA-(guanosine(2251)-2'-O)-methyltransferase-RlmB
MAANNRRMSGKKGAQIGSGGKRRRGLEGKGPTPPAEARKGHVKNRLANAKAKQQARRPKARPGQRSTSELVVGRNPVYEALRDGVPASTLYVQQFIDNDERVRDALALAAERGGIHLMEAPRPELDRMTNGLNHQGLVLQVPPYEYAHAEDLTAAAYDAGQDPLIVLLDGVTDPRNLGAVVRSVSAFGGHGVVVPERRAAGMTAGAWKSSAGAAARTPVARATNLTRTLEAYKKEGVVVVGLAADGEADVTDLPALEGPVAIVVGSEGKGLSRLVGETCDIRVRIPMPGGAESLNAGVAAGIVLYEAARRRA
>NZ_CP016824.1|WP_067414331.1|3977061_3978654_+|DoxX-family-membrane-protein
MVKVHCDPAQVIVNHASFRVQLPSAQKAQSPRISRLTGGASADTARIPVVGTVTRRRAPVVWSGRSAPGDGGATTGLLQAVRASGVRHGDDPPGATQVIPRVDPDEVATGEIPTLTGHTPGEPLLPRMRSAGSAYDDDTYTPRHGTPAYDGDDGGDRAGSDGGDGSDLDQDGRPKARSSVRHAYYPYRRMNLGVVLLPLRVGLGFATAYAGMSKLCDPAYFDGGERGSLMRWLGSLQPWSLAEPLHGFAVHHPVGVGLLVAFLQVLVGVLTVLGLWQRLAASAGAVLAAGLLITVSWRANPVYSMSDVIYLAAWTPLIIAGAPVWSVDGKLAADAWRKLGPRAELWQLRRWVLKRGLVVATVAVGLTLLFGALLGSAVRDADRVVVPRPGEPPRNSVPGMPLPSESGQVSGSPDASAGPDEAPSGGTSEGPSETSSGPAGSEQRETAGTGTTAPAETQGPGQAPPQQNAPQPPPQTSAGPGDDSSGGGSGEPGGGPGPGDGGGAEEPGEDPADGGSGGGGGPKLVGGLFG
>NZ_CP016824.1|WP_018471324.1|3978766_3979789_-|HlyC/CorC-family-transporter
MSFGLAMFVTVLLLIGSGFFVAAEFALVAAKRHRMEKAAAEGKRGAASALAGMKELSLMLAGAQLGITVCTLGLGSVSKPAVSHALDPVLVSWGLPASLSYGIAFAIAMIVVVFLHMVVGEMAPKSWAIAHPESSAMLLAPPFRGIVTVVRPLIWVMNRISNALVRLCRVTPRDELAEVHNREQLTHLVAESRRLGLISEDDSELITSSLTEPLSPVEALQVPAERIVSVPAGADAETILATASAHDRSRLLVRDGDRFIGSLHARDALITRARGRKATARALARPLPALTEGDTVGQAIELLRQRRASLALVQDREGRVTGLVSLDDLLARLLHPQEAA

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Crispr_ID: NZ_CP016824_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_22

4020993-4021231

Orphan

Consensus_repeat	Method
AGCCCGGCCGGCGTTTGAGGCCAT	PILER-CR

3 spacers

The CRISPR arrays of NZ_CP016824_22

>merge|NZ_CP016824|22|4020993-4021231|PILER-CR
AGCCCGGCCGGCGTTTGAGGCCGAGCAGTGACCGGCGCGGTGGGGCCGAGCGTCACCACACTTCAGCCCGGCCGGCGTTTGAGGCCATTCCGGGCCGGCACCGTGGAGCCGGGGCTCAGCCTGTCTCAGCCCGGCCGGCGTTTGAGGCCATCTCTGACCCGCAGGGTCGGGGCCGACAGGTGGAGGCGCAGCCCAGTCGCGTCGCGACCGAACCAAGCCCGGCCGGCGTTTGAGGCCAT

>NZ_CP016824|22|3|4020993-4021231|PILER-CR
AGCCCGGCCGGCGTTTGAGGCCGA	GCAGTGACCGGCGCGGTGGGGCCGAGCGTCACCACACTTC
AGCCCGGCCGGCGTTTGAGGCCAT	TCCGGGCCGGCACCGTGGAGCCGGGGCTCAGCCTGTCTC
AGCCCGGCCGGCGTTTGAGGCCAT	CTCTGACCCGCAGGGTCGGGGCCGACAGGTGGAGGCGCAGCCCAGTCGCGTCGCGACCGAACCA
AGCCCGGCCGGCGTTTGAGGCCAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067414377.1\|4022870_4024583_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|215457
NZ_CP016824.1\|WP_003949855.1\|4015627_4015831_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP016824.1\|WP_003949850.1\|4011640_4012702_+\|cobalamin-binding-protein	unknown	unknown	gnl\|CDD\|227345
NZ_CP016824.1\|WP_067414379.1\|4026502_4027054_+\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|376809
NZ_CP016824.1\|WP_030769919.1\|4014130_4014670_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP016824.1\|WP_008409868.1\|4025820_4026459_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003949857.1\|4017935_4018247_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067414371.1\|4019842_4020628_+\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238870
NZ_CP016824.1\|WP_067414368.1\|4018341_4019304_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223566
NZ_CP016824.1\|WP_067414387.1\|4029610_4030519_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176231
NZ_CP016824.1\|WP_030307725.1\|4014697_4015042_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133394
NZ_CP016824.1\|WP_067414384.1\|4028076_4029351_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP016824.1\|WP_067414390.1\|4030548_4031496_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378976
NZ_CP016824.1\|WP_079165354.1\|4012748_4013132_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP016824.1\|WP_003949866.1\|4027050_4027428_+\|fluoride-efflux-transporter-CrcB	unknown	unknown	gnl\|CDD\|223317
NZ_CP016824.1\|WP_067414374.1\|4021386_4022655_-\|tRNA-4-thiouridine(8)-synthase-ThiI	unknown	unknown	gnl\|CDD\|234960
NZ_CP016824.1\|WP_067414365.1\|4016245_4017757_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_CP016824.1\|WP_003949863.1\|4024725_4025646_-\|diiron-oxygenase	unknown	unknown	gnl\|CDD\|378680
NZ_CP016824.1\|WP_030307727.1\|4013652_4014003_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP016824.1\|WP_067414382.1\|4027444_4028080_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067414387.1\|4029610_4030519_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176231	cd08270, MDR4, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	2.68358e-104
NZ_CP016824.1\|WP_003949855.1\|4015627_4015831_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	3.10682e-34
NZ_CP016824.1\|WP_003949850.1\|4011640_4012702_+\|cobalamin-binding-protein	gnl\|CDD\|227345	COG5012, COG5012, Predicted cobalamin binding protein [General function prediction only].	7.02863e-19
NZ_CP016824.1\|WP_067414365.1\|4016245_4017757_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	1.43288e-118
NZ_CP016824.1\|WP_030769919.1\|4014130_4014670_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	4.12812e-15
NZ_CP016824.1\|WP_067414371.1\|4019842_4020628_+\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238870	cd01832, SGNH_hydrolase_like_1, Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. Myxobacterial members of this subfamily have been reported to be involved in adventurous gliding motility.	2.70046e-59
NZ_CP016824.1\|WP_067414368.1\|4018341_4019304_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	4.42094e-41
NZ_CP016824.1\|WP_067414377.1\|4022870_4024583_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|215457	PLN02852, PLN02852, ferredoxin-NADP+ reductase.	1.36648e-118
NZ_CP016824.1\|WP_067414384.1\|4028076_4029351_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.29332e-52
NZ_CP016824.1\|WP_067414390.1\|4030548_4031496_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|378976	pfam12852, Cupin_6, Cupin. This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily. Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.	3.54103e-31
NZ_CP016824.1\|WP_079165354.1\|4012748_4013132_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.60609e-15
NZ_CP016824.1\|WP_003949866.1\|4027050_4027428_+\|fluoride-efflux-transporter-CrcB	gnl\|CDD\|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	6.43239e-31
NZ_CP016824.1\|WP_067414374.1\|4021386_4022655_-\|tRNA-4-thiouridine(8)-synthase-ThiI	gnl\|CDD\|234960	PRK01565, PRK01565, thiamine biosynthesis protein ThiI; Provisional.	1.18045e-166
NZ_CP016824.1\|WP_067414379.1\|4026502_4027054_+\|CrcB-family-protein	gnl\|CDD\|376809	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB). CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance.	4.51051e-32
NZ_CP016824.1\|WP_030307725.1\|4014697_4015042_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133394	cd04766, HTH_HspR, Helix-Turn-Helix DNA binding domain of the HspR transcription regulator. Helix-turn-helix (HTH) transcription regulator HspR, N-terminal domain. Heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	7.07293e-09
NZ_CP016824.1\|WP_003949863.1\|4024725_4025646_-\|diiron-oxygenase	gnl\|CDD\|378680	pfam11583, AurF, P-aminobenzoate N-oxygenase AurF. This family is a metalloenzyme which is involved in the biosynthesis of antibiotic aureothin by catalyzing the formation of p-nitrobenzoic acid from p-aminobenzoic acid. AurF is a non-heme di-iron monooxygenase which creates nitroarenes via the sequential oxidation of aminoarenes.	5.73174e-103
NZ_CP016824.1\|WP_030307727.1\|4013652_4014003_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.45894e-20
NZ_CP016824.1\|WP_067414382.1\|4027444_4028080_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.82398e-68

>NZ_CP016824.1|WP_067414371.1|4019842_4020628_+|SGNH/GDSL-hydrolase-family-protein
MSVVRYVALGDSQTGGRGDGDEASGLRGWADRLAELLDAAEPGLRYANLAVRGQLAGQVRATQLDAALALRPDLATVVAGMNDLLRPRFDADAVGAELEAMFAALTGAGARVATLTFPAMERLVPLARPLAPRVPALNARIREAAARHGVLVVETYGEEVVVDPRLWSPDRLHAAPLGHARIAAAFAHALALPGSDRGWAVPLPAVPPVRGVRALAAEARWVSGFLGPWLGRRVRGRSSADGRVAKRPGLAPLGTAGRAGD
>NZ_CP016824.1|WP_067414368.1|4018341_4019304_-|NAD(P)/FAD-dependent-oxidoreductase
MPTPHTYDVVVIGGGAAGLAGAVTLGRARRTVLVVDAGTPRNAPAAGVHTFLSREGVSPAELLRTGRAEVTSYGGEIREGTVTDARREGGGFVVTLADGSEVSARRLLVTTGITDELPPVQGLAALWGKDVLHCPYCHGWEAQDLPTGVLATGPPSVHQALLWRQWTDDLTLFTHTTAGPTPEEREQLEARGTRIVDGEVTGVETDGEGRLAGVRLADGSTVPVRALATGGTLTARAGFLAGLGLETVPVEVGGTVIGSRLDTDATGLTSVPGVWAAGNVASPTDQVVISAGAAVRAAAVLNMDLVTEETRRAVEARRAG
>NZ_CP016824.1|WP_003949857.1|4017935_4018247_+|hypothetical-protein
MRCVIARFPFDLVKSEVVAKMKGVKPEPVTGEYVIIGRHHYPVKQVGEVITRQDRRDFSAGEVTRALTRLGFTCRPAPGTEPAVERTAVETAAAQLGGAPEQG
>NZ_CP016824.1|WP_067414365.1|4016245_4017757_+|DEAD/DEAH-box-helicase
MNQNRASRDDNRTGRRSGGGHRGAGAPRSAGPDRFRSPVRGGPQGARRSGGERTRAGARGEFAPPVTGTPALPPVDAFDQLGLPAPLLACLTAQGVTEPFPIQAATLPNSLAGRDILGRGRTGSGKTLAFGLALLARLEGRRAEPRSPLGLVLVPTRELAQQVTEALTPYARALRLRMTTVVGGLSLGRQASALRGGAEVVVATPGRLKDLIDRGDCRLDQVGATVLDEADQMADMGFMPQVTELLDQVRPGGQRLLFSATLDRNVDLLVRRYLDDPTVHSVDPSAGAVTTMEHHLFQVHGPDKHALATEIAARDGRVILFLDTKHAVDRLAEHLLRNGVRAAALHGGRSQAQRTRTLTQFRDGHVTALVATNVAARGIHVDDLDLVVNVDPPADHKDYLHRGGRTARAGASGSVVTLVLPEQRRSMSRLMADAGITPQTTRVRSGEAELSRITGARTPSGVPVVVRAPAPAPPRRGASSSRGRRSPAAQARRAAAVRARPAA
>NZ_CP016824.1|WP_003949855.1|4015627_4015831_+|cold-shock-protein
MATGTVKWFNAEKGFGFIEQDGGGADVFAHYSNISAQGFRELIEGQKVSFDVTQGQKGPQAENIVVA
>NZ_CP016824.1|WP_030307725.1|4014697_4015042_-|MerR-family-transcriptional-regulator
MQVTRKTPPDPADKFDDEDYPAYTMGRAAEMIGATPAFLRAVGEARLITPLRSAGGHRRYSRYQLRVAARARELVDQGTPVEAACRIVILEDQLEEALRVNERLRDAASAAPRD
>NZ_CP016824.1|WP_030769919.1|4014130_4014670_+|ATP-binding-protein
MTVDEGDGDLIQYRQGAARAGNGRRPAQAPRIVEAPQHRQTRRTPQVPGTAGEARALVQQALRDSFGPDATGDTGDGLGDTVVVADALLVTSELVTNAIRHGGGLTGFDVQLEESHLTLHVSDASPELPAATRPDGPFDPDRPLVGGYGWPLVRRLCREVSVRPLPGGGKCVTVTLSLV
>NZ_CP016824.1|WP_030307727.1|4013652_4014003_+|STAS-domain-containing-protein
MLERSGMDITTSAELSAFVIGVHGDVDLHTAPALDAALAQALRAETSRTVVDLSGTGFADSSILGSLLRALRDHREQGRRLILAGPMSDLVTRLFEVTGTLAAFETAPDARAAREQ
>NZ_CP016824.1|WP_079165354.1|4012748_4013132_+|STAS-domain-containing-protein
MTPLNDPDDPDDPGGTGLTLTAEPAAPGTLALRLAGALDHESADALVREVARRLAERPAPRLLRLDCAGLTACDSLGLSALLMIGRRTGAAACALRLDRRPPHLDRLLEITGTHGYLVGPGEEPGPA
>NZ_CP016824.1|WP_003949850.1|4011640_4012702_+|cobalamin-binding-protein
MTTRTPEETVTAAEPLRALLWDALLAGDEYAAADVLFAALDDGLSAEEALLDVIGPVQAEVGLGWAANRLSVVQEHAATAMNDRIIAALAHRSPPPGEGRGRIAVACVEGEWHALPARLLAETLRLRGWRVDFLGAQAPTPHLIAHLHQTGPDLVALSSSIPTRLPTAHAAITACQAAGVPVLAGGAAFGADGRYARLLGADGWAPDARSAADVAAGGLGVPSGAVLHEPVDDLPHLADQEYTLVSRGRTRLVRETVDGLDDRFPAMRGYTERQRERTAEDIAHIVDFLATALYVDDDALFTSFLVWTAGILEARGVPARSLTPALELLGEPLRDFPRATRLLHRGGAALTGG
>NZ_CP016824.1|WP_067414374.1|4021386_4022655_-|tRNA-4-thiouridine(8)-synthase-ThiI
MNAVVPAQGVPDLAGPVPIGPCVLLKHGEVFLKGRNRHLFVERLHDNLRGALRGVTGSIWIKEMQNVTVLGGDAPQDELIARARRVMGFVAVQPAMRVETGEEAIVAAAVAALDGAASGTTFAVRARRRHKPFPLTSTQLERLVGARIQEAHGLPVDLTRPDIRVEVEIDRKESYVSGLRHTGQGGLPVGTSGRALVLLSGGYDSPVAAHRAMRRGLRCDFVHFTGAPYTNAASAFKAYALARELNRYQPPGKLHIVALGHAQKQLAVAGAGRFQVVGQRRLMVKAASVLARRLRAQALVTGDALGQVASQTLSNMALVDEAATLPVLRPLIGWEKQEIIDEARRVGTAEISVLPDEDCCQLLAPRQVSLRTKLEDVAGFEKRLDADELIDQMLASAQVTRPGTDETPAPATPPAAPACGTD
>NZ_CP016824.1|WP_067414377.1|4022870_4024583_-|FAD-dependent-oxidoreductase
MTYAITQTCCNDATCVAVCPVNCIHPPPEERAFGSTEMLHIDPRSCIDCGACADACPVDAIFPVDRLKPAHREYAALNAAYYEEEATTTEREEAAAAPAAVTGDGAEAQAEAAERTGPLFRAWDAPGFARSLPSDFAPLRVAVVGTGPAGMYAAEDLLLHTDAQVTLVDRLPVAGGLIRYGVAPDHPATKKVGEAFARFHHHPRVRMQLGLEVGKELSAAELAAHHDAVIYAVGAATDRRLGIPGEELPGSVSATGLVAWYNAHPDHAPDAVSLDAERVVVVGNGNVALDVARILVSDPDTLAATDIAGHALDALRGRRVREVVLLGRRGPEDAAYTRTELLALGHLDGVDLVVDDHDPRIGAAIDAAGPLDKAGMLGGVTRTAVDWSRPPEPGRRIVFRFHSAPLAVTGEQAVTGVQVTGGTEIPAQLVVRSIGHRGVAVPGLPFDETTGTVPHEGGRVRGRSNEYVVGWIKRGPSGGIGANRSCAAETVTTLLADAVAGELPTPSGSAKEFARLARRRNRRLVDARGLAAIERAERESGRRDGRVRTKFATVPELVAAARRSRLRLPG
>NZ_CP016824.1|WP_003949863.1|4024725_4025646_-|diiron-oxygenase
MATTDAQPAAQDEGGHDINDITRRLLESSAKLSYDPATEVDWDTPLDKSFHGMSPEWSSLYGTRYWDELTEDQRKELTRQESGSVASTGIWFEVILQQMVLRDIYAKDPGSPEFQWALTEIADECRHSIMFARGVRKLGAPAYKPRRAVMELGRLFKTLAVGEAAYASILVAEEVLDVMQRDWMRDERVVPFVRTINNIHVVEESRHMKFARDETIKRLEKAGWLRRNVQALVISICAYFVITSMWNRDVYRNAGLNTERALAEAKANQHHKSMIRSSCSGLMDFLASAKLLTRPAAAVYRRANLL
>NZ_CP016824.1|WP_008409868.1|4025820_4026459_-|hypothetical-protein
MRPPAAPAPADPPGPGPEPEPGWNVALRRLLGDPYVFVATGPRRHEEWARDVLAVLRREVADPRGRPGLDADRTGPGRDAVPAYPFAPPPAERFPAYLRPLERAAAVGALAVMSEEWQFEPAPVRSRPDREAVLADARTLLDRYGPDAEYWTNAVAAGSGPAPDFVAAGLRGTASYTFLTGAYVNGLDLCDDLGLIAVSADEVGVFWSVGAC
>NZ_CP016824.1|WP_067414379.1|4026502_4027054_+|CrcB-family-protein
MSHPPHTPDGAAPDPRESHRANLPLPPPEPVDPDLGPELARGERPESQAPVLLAIALGGGLGAVIRYGATVLWPTPAGSFPWTILVVNVVGCAAMGVLMALLTEVWPEAPRLTRPFLGTGGLGGFTTFSTYAVDVQTLFDGGSPGRALGTLVLTVAAALAAVAGASWLTRSAVRLGRAEGTLA
>NZ_CP016824.1|WP_003949866.1|4027050_4027428_+|fluoride-efflux-transporter-CrcB
MTWLLVVVGGMIGAPCRYLMDRAVQRRHSSGFPWGTLAVNMSGSLVLGVLVGARLTGAAPENLMVFAATGFCGAYTTYSTFSYETLRLAETGARGAAFANVALSVSAALGAAVMGLGVAKAVWGG
>NZ_CP016824.1|WP_067414382.1|4027444_4028080_-|response-regulator-transcription-factor
MTAIRLLLADDHPIVRAGLRAVLETEPDFEIAGEAASAEEAVALAGRLAVDVVLMDLQFGPGARMNGSEATAAITARPGAPRVLVVTTYDSDADTLPAIEAGATGYLLKDAPPEELAEAVRTAAAGRTTLAPAVADRLLRRMRTPGTALSRRETEVLGLVAEGMSNLRISERLHLSQATVKSHLVHIYAKLGVDSRTAAVAAALERGLIRR
>NZ_CP016824.1|WP_067414384.1|4028076_4029351_-|sensor-histidine-kinase
MPSTTPAPAPPRAPLSTPAPRVLAWCLHLLVAALLVMAVGRALVDGGGQGWAVVVAGVAFGAVYAAGPVVPGVRGSRRGAVVWLVAVGVLWAGLLGLTADAMWLAFPLFFVQLHLLAGRAGPWAVALTTGVAVCSYAAHQGGFTAAAAIGPVIGAAVAVAVVRGYQALYRESEQRRRLIEELTRARADLAAAQHTAGVLAERERLAREIHDTLAQGLSSIQLLLRAAQRSLGGEEGAGRYVEQARQAAADNLAEARRFVAALAPQDLEGTTLAGALERLCATTSATAPLTVRFHLAHDPGPLPAAYEVALLRIAQAALGNTVRHAGARTAEVTLSGLGDAVALDVVDDGRGFDPAALPAPDPDRGGFGIPAMRARTRALGGTLTIESRPGGGTAVAAQLPLPAEGTRPHPGPEPDPDPVPEAPR
>NZ_CP016824.1|WP_067414387.1|4029610_4030519_+|zinc-binding-dehydrogenase
MRALVVDHGSSGPVRFAEVEEPVPSRDQALVAIRHIGLNFGELNYVDQWPAGAVHGHDASGVVVRAAADGSGPPEGTRVALGMSAHAWAERVAVDPASLAAVPEGVELADGAAPGIAGVTALRVLRTRSLLARDVLITGAGGGVGRFAVQLAALAGARVTALVGSPDRAAGLRALGADEVLTSLAGTESRFDLVLDTVGGPLLAQAWDRLAEGGTLHAVGYSSGQDTTFPSGTLFGFGAPRTLATFGDMTPTSADLTELLDLMAAGRLSAPVGRRGVWQDVDDAVQALFARKVHGKIVLDVV
>NZ_CP016824.1|WP_067414390.1|4030548_4031496_+|AraC-family-transcriptional-regulator
MDVLAEALRVSGARGALGVVLKAGGSWGLWLDPSPAAALHVVARGTMWLHVPGGEPLEVRAGDAVLLAPGTAHGIAGGTRTTLGPCDREATGRALTDGTALHLGSAPAQTEVLVLRYERDPEVSTPVLSSLGRPMHVTSRENTQLRMTVELLTAELAHPQTGTTAAVNSIVDLLLIQFVRVWLARRPEGNSGSWRGALRDPVVRDALERVHARPEHPWTTASLAAATAVSRTTLSRRFRSALGQTPGAYLTQWRMDLAAVRLRDTDEPVESLSGAVGYASPHAFSRAFRRARGLPPGEYRVRVRAEADAWPRPLP

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Crispr_ID: NZ_CP016824_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_23

4082232-4082317

Orphan

Consensus_repeat	Method
TGGCCTCAAGCGCCGGCCGGGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_23

>merge|NZ_CP016824|23|4082232-4082317|CRISPRCasFinder
TGGCCTCAAGCGCCGGCCGGGCTGTTGGTGGCCGGGCTTCGTCCTGGCCGTGCCGGTGAAAGATGGCCTCAAGCGCCGGCCGGGCT

>NZ_CP016824|23|20|4082232-4082317|CRISPRCasFinder
TGGCCTCAAGCGCCGGCCGGGCT	GTTGGTGGCCGGGCTTCGTCCTGGCCGTGCCGGTGAAAGA
TGGCCTCAAGCGCCGGCCGGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_003949934.1\|4078132_4078708_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NZ_CP016824.1\|WP_067414452.1\|4074784_4076107_-\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379232
NZ_CP016824.1\|WP_067414465.1\|4091118_4091451_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067414457.1\|4080415_4082146_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP016824.1\|WP_018893864.1\|4078909_4079377_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|181730
NZ_CP016824.1\|WP_010643448.1\|4072238_4072589_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_008412564.1\|4090380_4090689_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_030770508.1\|4082654_4083635_+\|carbohydrate-binding-protein	unknown	unknown	gnl\|CDD\|271149
NZ_CP016824.1\|WP_003949944.1\|4089173_4090106_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP016824.1\|WP_067414449.1\|4073422_4074778_+\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341066
NZ_CP016824.1\|WP_067414455.1\|4076244_4077420_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176242
NZ_CP016824.1\|WP_067414462.1\|4087998_4089174_-\|N-acetylglucosamine-6-phosphate-deacetylase	unknown	unknown	gnl\|CDD\|238434
NZ_CP016824.1\|WP_030770514.1\|4090670_4091084_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003949939.1\|4083736_4084582_-\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|376459
NZ_CP016824.1\|WP_067414460.1\|4086933_4087839_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133378
NZ_CP016824.1\|WP_003949940.1\|4084653_4085583_-\|1-phosphofructokinase-family-hexose-kinase	unknown	unknown	gnl\|CDD\|274464
NZ_CP016824.1\|WP_030308196.1\|4085747_4086695_-\|lytic-polysaccharide-monooxygenase	unknown	unknown	gnl\|CDD\|376983
NZ_CP016824.1\|WP_037844489.1\|4079409_4079997_-\|flavin-reductase	unknown	unknown	gnl\|CDD\|214900
NZ_CP016824.1\|WP_018893863.1\|4077419_4077992_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|235142
NZ_CP016824.1\|WP_010643447.1\|4072693_4073203_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_003949934.1\|4078132_4078708_-\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	2.98915e-117
NZ_CP016824.1\|WP_067414452.1\|4074784_4076107_-\|VCBS-repeat-containing-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	1.32796e-06
NZ_CP016824.1\|WP_067414457.1\|4080415_4082146_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.46819e-42
NZ_CP016824.1\|WP_018893864.1\|4078909_4079377_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|181730	PRK09256, PRK09256, aminoacyl-tRNA hydrolase.	2.19813e-57
NZ_CP016824.1\|WP_037844489.1\|4079409_4079997_-\|flavin-reductase	gnl\|CDD\|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	5.10268e-45
NZ_CP016824.1\|WP_030770508.1\|4082654_4083635_+\|carbohydrate-binding-protein	gnl\|CDD\|271149	cd04083, CBM35_Lmo2446-like, Carbohydrate Binding Module 35 (CBM35) domains similar to Lmo2446. This family includes carbohydrate binding module 35 (CBM35) domains that are appended to several carbohydrate binding enzymes. Some CBM35 domains belonging to this family are appended to glycoside hydrolase (GH) family domains, including glycoside hydrolase family 31 (GH31), for example the CBM35 domain of Lmo2446, an uncharacterized protein from Listeria monocytogenes EGD-e. These CBM35s are non-catalytic carbohydrate binding domains that facilitate the strong binding of the GH catalytic modules with their dedicated, insoluble substrates. GH31 has a wide range of hydrolytic activities such as alpha-glucosidase, alpha-xylosidase, 6-alpha-glucosyltransferase, or alpha-1,4-glucan lyase, cleaving a terminal carbohydrate moiety from a substrate that may be a starch or a glycoprotein. Most characterized GH31 enzymes are alpha-glucosidases.	4.22586e-13
NZ_CP016824.1\|WP_003949944.1\|4089173_4090106_-\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.99041e-59
NZ_CP016824.1\|WP_067414449.1\|4073422_4074778_+\|M1-family-metallopeptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	1.22691e-154
NZ_CP016824.1\|WP_067414455.1\|4076244_4077420_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176242	cd08282, PFDH_like, Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH). Formaldehyde dehydrogenase (FDH) is a member of the zinc-dependent/medium chain alcohol dehydrogenase family. Unlike typical FDH, Pseudomonas putida aldehyde-dismutating FDH (PFDH) is glutathione-independent. PFDH converts 2 molecules of aldehydes to corresponding carboxylic acid and alcohol. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like the zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these tetrameric FDHs have a catalytic zinc that resides between the catalytic and NAD(H)binding domains and a structural zinc in a lobe of the catalytic domain. Unlike ADH, where NAD(P)(H) acts as a cofactor, NADH in FDH is a tightly bound redox cofactor (similar to nicotinamide proteins). The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of an beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	2.31137e-165
NZ_CP016824.1\|WP_067414462.1\|4087998_4089174_-\|N-acetylglucosamine-6-phosphate-deacetylase	gnl\|CDD\|238434	cd00854, NagA, N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to amino-sugar-nucleotides, which is needed for cell wall peptidoglycan and teichoic acid biosynthesis. Deacetylation of N-acetylglucosamine is also important in lipopolysaccharide synthesis and cell wall recycling.	5.34365e-150
NZ_CP016824.1\|WP_003949939.1\|4083736_4084582_-\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|376459	pfam01116, F_bP_aldolase, Fructose-bisphosphate aldolase class-II.	1.48345e-102
NZ_CP016824.1\|WP_030308196.1\|4085747_4086695_-\|lytic-polysaccharide-monooxygenase	gnl\|CDD\|376983	pfam03067, LPMO_10, Lytic polysaccharide mono-oxygenase, cellulose-degrading. This domain is found associated with a wide variety of cellulose binding domains. This is a family of two very closely related proteins that together act as both a C1- and a C4-oxidising lytic polysaccharide mono-oxygenase, degrading cellulose. This domain is also found in baculoviral spheroidins and spindolins, protein of unknown function.	2.1203e-51
NZ_CP016824.1\|WP_067414460.1\|4086933_4087839_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	1.59317e-19
NZ_CP016824.1\|WP_018893863.1\|4077419_4077992_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|235142	PRK03624, PRK03624, putative acetyltransferase; Provisional.	8.97629e-08
NZ_CP016824.1\|WP_003949940.1\|4084653_4085583_-\|1-phosphofructokinase-family-hexose-kinase	gnl\|CDD\|274464	TIGR03168, 1-PFK, hexose kinase, 1-phosphofructokinase family. This family consists largely of 1-phosphofructokinases, but also includes tagatose-6-kinases and 6-phosphofructokinases.	6.78738e-106

>NZ_CP016824.1|WP_067414457.1|4080415_4082146_+|diguanylate-cyclase
METESEPYVRLATLRQLHQVIADLNSARSLADTLQTVADGVVTGLGYELSAVNLVQADGDLVVAAVAGNSSAEALLTGQVGPRHAWDHRLSLAEHWGDLRFISHTEAWQLDEDGVPGWYTPAPVPRYEDEWHPGDRLFAPLHVTGSDELLGVISVDRPRNGRLPGPWGQEAFQMYAFQAAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEFAPSGMAIAEMGGDQHGRILRANDALCRLLGRRAGTLRRYTFSDLAHPEDIGTLLRTSAEGGRTEVRLSTSEGAYLWVSLRNSVVADATDGPRLLLTHVEDITERKRHEMQLAHRASHDALTGLPNSAELRARLSARLCTRPHAGRPSAVDTLDAAYGGPAPGSFPGPVADPDAYDADAHDFDLGLGVGGARHAAGPTGAGFGVAPYEHHVHTVAPDEDGDQDGEGAKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLTSGVRDGDTVARLGGDEFVVLADGLCHADAQDLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAHCGMSVEEVLQSADQRMYIEKRSRSKQQRRAG
>NZ_CP016824.1|WP_037844489.1|4079409_4079997_-|flavin-reductase
MFTTRATSGSPAPAVPAVPSAGPGHAEGVSNEEFRAAMSRLAAGVVLVTAHDPEDGPRGEDAGMTATAFVSVSLDPPLVMVSVRTGSRMDDVLTDRPLWAVSLLGEDQRDIAGRFAMSGRLSDSLLFASLPHTRGEFTGAPLIEGGLGAVECRTEQRVQAGDHTLLIGRVLSAALPAAEGGPLVYYRGRYRHLGR
>NZ_CP016824.1|WP_018893864.1|4078909_4079377_+|aminoacyl-tRNA-hydrolase
MSTDRKPGTPKPAPTGGRVIRGSVVLPDSELTWRFSRSSGPGGQHVNTSDSQVELRFDLAATQALPEVWKERALERLAGRLTGGVLAVRASDHRSQWRNRETALDRMVSLLGEATAPPPRQRRATRIPRGINERRLREKKQRSEVKKNRGRGGDW
>NZ_CP016824.1|WP_003949934.1|4078132_4078708_-|TerD-family-protein
MAVSLSKGGNVSLTKEAPGLTAVTVGLGWDVRTTTGTDFDLDASAIAVNAEGKVYSDGHFVFFNNKQTPDQTIVHTGDNRTGEGDGDDEAINVNLAGLPADVDKIVFPVSIYDAESRSQNFGQVRNAYIRIVNQAGGTEIARYDLSEDAATETAMVFGELYRNGAEWKFRAVGQGYASGLVGIAQDFGVNV
>NZ_CP016824.1|WP_018893863.1|4077419_4077992_-|GNAT-family-N-acetyltransferase
MAAMYVDIVTPDDAALPGALLTEITGVYASAQAFHELTGDFPDAGDIRVPQVAAALADELAVPGSVVHLARVRGELVAVAVTLDHHPADPDDPDPWIGLLLVHGERRREGHGRALAGHLAARFREAGRTGLRLAVLDTNTAALTFWQALGYVPVDHRPDLRRGRECTVLRLPLAASREGRAEAGATAGES
>NZ_CP016824.1|WP_067414455.1|4076244_4077420_-|alcohol-dehydrogenase-catalytic-domain-containing-protein
MRAVVYEGERRVAVREVEDAVVEEETDALVRITSSALCGTDLHMYDGRTGAEPGLVLGHEPLGVVEATGSAVTSVRPRDRVVLPTHLYCGTCPHCAQGLTAACSRVRPGGFGAAYGYAGMGPYRGAQAELLRVPFADANCVPLPGEPGDRFEDAFVLLADAFVTGWHATELAGVGPGDSVAVFGAGTVGLLAAHSALLRGAGEVYVVDHVPARLAVAAGFGAVAVDFTAGDPVEQIRVHRRARGLPPGEAGTGGVDRGIDAVGFQARDRADTARENPAQVVDDLARLVNPTGSLGIAGVYAAKDLHPAAPAGHRDGSLRVPWAQLFDKGVRVGFGRTHDRRYTRLLRDLILDGRAHPERVVTHHGTLDDAPDFYATFDRREDGMVKAVLRP
>NZ_CP016824.1|WP_067414452.1|4074784_4076107_-|VCBS-repeat-containing-protein
MFRRPGGRHVLVTVLVAVAVLAYLVLLPSDEVAPVPGSPCRADGPARTDPLLAPDLDGDGFGELVYEDAREPDGFQVVVVPGSARGPDAGRATVLDRDDLGVPDSVQSIDDTWRPTVADLDGDGHLDLVVSGAAQVVWGGPDGPRADGPRGRVPLPGGPYAGAPVAGDVDGDGHTDLVAYRFTAENPGLVVLKGPFERSGAPADTVEIPTPVNEAASPALLLGDADGDRAADLAVYDSPYDPPLLLSGGADTPSGLSDKPRRLPAGESVAFGDFDGDGRRDIAVGQSFVDPYDEEETPYRRGQVRIAYGKEPGTWVTVEGGAPQEGFGTRLGAGDFDGDGCDDLAVQLTRKKEAADARFAVLHGGSDHGLASEPWRTVRRTVAEPSGPVDDGPVDGSLFAAADWDGDGHAELALAGGGHWWFTDGTDRDTASFPEPGRAG
>NZ_CP016824.1|WP_067414449.1|4073422_4074778_+|M1-family-metallopeptidase
MHGTPGAAGVLDPLFPRLGNGGYDVRHYDLALDWAPATSGERAEQPLRGTARITSRATQNLSAFNLDLKGLEVTSVTVDGRPARYGQAGTELTVRPEKELDKGSTFRTTVEYAGRPGPLEDADGSEEGWLTGKAGTVALGEPSGAMTWFPGNHHPLDKATYTLRATVPKGQRAVSGGEPETLEPKPRADGRTTWTWNSRRPMASFLTTLAIGRYELSTGRASSDLPLVNAVAPGEDAEVLERLPEVLDWSVQRFGAYPFDSYGALVLDPGTAGYALETQTRPVYPGAPGVGLVVHETAHQWFGNSVTPRTWQDIWLSEGFATYAEWLWEEDHDGPTAQSTFDRLYATSEDAELWAFPPADPPGPDDLFSDPVYQRGAMTLHQVRRLLGEDRFARLLTGWPKKHAYGHARTADFTAYAESLAPDTATREALTRTWSAWLRAEGKPDSARPGR
>NZ_CP016824.1|WP_010643447.1|4072693_4073203_-|hypothetical-protein
MLDIGYALSSRFPDPSDLDYARVDRHALRHDLFCGDVYLADTKADRELSTAWGWVPVLDFAWALCDIVEQVDQDPRGSRAARPQYAELDFTESSDRMLFTRRFGWVDIEADWMKADEPPLTFSHTELRREARDFLHDVVADLCDLHDSLADNPVVWDLQARFPRLPAPR
>NZ_CP016824.1|WP_010643448.1|4072238_4072589_-|hypothetical-protein
MNHSHAAPGTTRMTPHRARPPRRGNTKYPLSPSTVRVLRWGRWFSLTLAVLTWAVVITALVTGSWGADLFLLVTNAVGAVLWPAHAAWSFHALRRHRAAVAAAGAVDHADRADAVV
>NZ_CP016824.1|WP_030770508.1|4082654_4083635_+|carbohydrate-binding-protein
MTPGPGNNGASGDNGTPEGDDPFGYLYADGQAAGATPPGGGGGYGYPGPRSSYNQVRAVGERRYGGQQAQGQQGGYGYPPQQQPYGQAPQGVPPQQQHGAPPPVAPGGGRGRGSGSGGPNTRMLLIGAVAVVVAVIVVIAVTMFSGDDDKGDEAGKDTAPTADAGGGEGEDEQQEKPQDDEEDKPVDLPKTDAKALKLEGGTVTASDIQGAEAGTYVAGFNKVGAKVTWTVNGIPEDAGYSLRVSYGVPGKAANATILVNGKAQERPLNMDNFANVEEGEWSDKWVNTWAVVNLTKGTNTITLSCEEGNQCDANFDQLWLKEGTQG
>NZ_CP016824.1|WP_003949939.1|4083736_4084582_-|class-II-fructose-bisphosphate-aldolase
MPLVPTGELVTEAAAAGRAVAAFNVITLEHAEAVAAAAEEAGLPAVLQISQNAVAYHGHRLGPIAAATGAVARCSTAPLALHLDHADSWELVEAAPAEGFGSVMYDASRLNAEENLRRTAEAVRFGHAHGLWVEAELGRIGGKPGEPPLDAHAPGVRTDPAEAAAYVKETGVDALAVAVGSSHAMTERTAALDHTLIAALRSAVPVPLVLHGSSGVPDEELAHAVRSGMTKINIGTALNQAFTSALTTHLTDHPDPRPYLSLARAAVRGRAHHFLTVLSGV
>NZ_CP016824.1|WP_003949940.1|4084653_4085583_-|1-phosphofructokinase-family-hexose-kinase
MILTVTLNTAVDLTYHVPTLRQHTTHRVTETQDRPGGKGVNVARVLARLGHPTTVTGFAGGPTGAWLREALSGEPHLKDALVPIGGTTRRTVAVVDAAGGDTTQFNEPGPTVTAAEWEALKKAYASLLPGAEAVALCGSLPPGVPVGAYAHLIREARSAGVPVLLDTSGEPLRRGIAARPDLVKPNAAELADLTGTRDPRHAARAARRRGARAVVASLGAEGLLAETPVGAWRAAPPGPVRGNPTGAGDSVVAGLLAGLAEGADWPDRLVRAAALSAATVHASAAGEYDEAAYRDLAARITATALPGAA
>NZ_CP016824.1|WP_030308196.1|4085747_4086695_-|lytic-polysaccharide-monooxygenase
MAIHSIRTRHTLALAAAAGVAAAVLSVPSPASAHGVSIMPGSRTNLCYKDLLQNGSTQMPSNPACADAVRQTGTTPLYNWFAVLDSNAGGRGAGYVPDGKLCSAGDRSPYDFSAYNAVRTDWPKTHLTSGATIQLKYSNWAAHPGKFEVYLTKSGWNPNQALAWGDLDHLQTVTDPPQNGGVGTNEGHYYWNLQLPQRSGQHMLFIQWIRSDSQENFFSCSDVVFDGGSGEVTGLAGGEQSAAEVEALGADVENTKADPIHAAGHTEHAAAGEELAASGNEAAGAVPAVVAGLGAVVFAGGAMVFNRSRRTRQHG
>NZ_CP016824.1|WP_067414460.1|4086933_4087839_-|MerR-family-transcriptional-regulator
MYPALTPPRQVKIGDAAAFAGTTPRAIRHYHAIGLLPEPERGGDGRRRYGYDDMIRLLWIRKMADAGISLDDMRAAFGEARDETRDESGDEASDQAPGIESVLGRLEASLAAQEAAVRRRRAAVQRLRAVGSPLGLLSELVTDRLSPLPPGALRPSDLDALLVTERICGPLGAAIQASAFIVLATHPDLRAEDDRLEAAEAALDDGVAPDDPRVEELAVQRCAHQMALNQAIEAAGLGAAEAKILETYDAGLTGEEATVMSAATALTKMPYDFSPARMRCLELAGRLFGEALADAHPAESS
>NZ_CP016824.1|WP_067414462.1|4087998_4089174_-|N-acetylglucosamine-6-phosphate-deacetylase
MAAPARKVLTGARVVLPSGTVDDGEVVIDGAHIGGSAPSAGQEGEAERWDLSGHWIVPGFVDLHNHGGGGASFTSGTVDDVLTGIATHRAHGTTTLVASTVTGEMDLLTARAGLLSELTEQGDLAGIHFEGPFISPCRKGAHSEALLRDPHPADVAALLDASRGAARMVTLATELPGGLDSVRLLADRGVIAAVGHTDATYEQTVEAIDAGATVATHLFNAMPPLGHRAPGPIAALLEDERVTVELINDGTHLHPAALELAFHRAGADRVAFITDAMDAAGFGDGRYLLGPLEVDVVDGVARLVEGGSIAGSTLTLDRAFRRAALVDKLPVDQIVRALSANPARLLGLDHRIGSLEPGKDADLVVLDEGFEVKGVLRHGDWVVAPQVAAAA
>NZ_CP016824.1|WP_003949944.1|4089173_4090106_-|ROK-family-protein
MRHVIALDVGGTGMKAALVGPDGELLHEARRDTGRDRGPDAVVASILDFADALRAHGLAEFGEQAAAAGVAVPGIVDTEKGVAVYAANLGWSDVPLRDMLTARLGGTPVALGHDVRTGGLAEGRIGAGRGADRFLFMPLGTGIAGAIGINGVIEPGAHGSAGEIGHVVIRPGGIPCGCGQRGCLERLASASAVSLAWAEASGDPEADAADCARAVAAGDPRAVAVWQEAVDALADGLVMAVTLLDPRTLIIGGGLAEAGETLFTPLRAAVEERVTFQKLPTIVPAALGDTAGCLGAGLLAWDLLATEVSA
>NZ_CP016824.1|WP_008412564.1|4090380_4090689_+|hypothetical-protein
MVEGEYGIGEGPATRVSLSLPEGTAEAIRARVGKREFSAFVAAAVERELRGQILDEYLTDYERRHGPLPARLQAEARQVFDDVFSQDAALREDEGKQWPAAS
>NZ_CP016824.1|WP_030770514.1|4090670_4091084_+|hypothetical-protein
MARRKLTHEGTLLLDSEGLSKLLVDDARTVAMIAEARRRGMDVVICALALIEAVHARTDRRRLAWVLSGLRVAPVGEEEAKAASALLPRTGLHGHKYAIDAAVAELATRQQRPVALLTSDLDDMGKLCEDHVRLIAV
>NZ_CP016824.1|WP_067414465.1|4091118_4091451_-|hypothetical-protein
MPYSFLLRLLPTETPPHLYRATVHNADGTHEAFLLLTPDPPSVHLTDARGNPSGGLRMSLADGTVERTDAEPQEAHPALTTEDFMTVAAHLLTQHGRQGRPPGEVCRVFA

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Crispr_ID: NZ_CP016824_24

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_24

4202356-4202515

Orphan

Consensus_repeat	Method
GGGACCAACCCCGCACGCGCGGGGAGCAG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP016824_24

>merge|NZ_CP016824|24|4202356-4202515|CRISPRCasFinder
GGAACCAACCCTGCACGCGCGGCGGGGAGCAGCAGCAGAAGAAGAAGCCCAAGCCCAGCGACCGGGAGAAGGGACCAACCCCGCACGCGCGGGGAGCAGCGGTGGATGTGGAAGCTCATCTACCTGTGCACGGGACCAACCCCGCACGCGCGGGGAGCAG

>NZ_CP016824|24|21|4202356-4202515|CRISPRCasFinder
GGAACCAACCCTGCACGCGCGGCGGGGAG	CAGCAGCAGAAGAAGAAGCCCAAGCCCAGCGACCGGGAGAA
GGGACCAACCCCGCACGCGCGGGGAGCAG	CGGTGGATGTGGAAGCTCATCTACCTGTGCAC
GGGACCAACCCCGCACGCGCGGGGAGCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067414603.1\|4206971_4208459_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP016824.1\|WP_067414589.1\|4198481_4200377_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP016824.1\|WP_051701319.1\|4202793_4203513_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP016824.1\|WP_067414586.1\|4195522_4198102_+\|protein-kinase/lanthionine-synthetase-C-family-protein	unknown	unknown	gnl\|CDD\|271199
NZ_CP016824.1\|WP_008415578.1\|4198191_4198323_+\|SapB/AmfS-family-lantipeptide	unknown	unknown	gnl\|CDD\|380211
NZ_CP016824.1\|WP_067414592.1\|4200373_4202305_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP016824.1\|WP_008406155.1\|4208870_4209731_+\|DUF3027-domain-containing-protein	unknown	unknown	gnl\|CDD\|378605
NZ_CP016824.1\|WP_003950021.1\|4204214_4204598_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP016824.1\|WP_067414595.1\|4203821_4204073_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067414606.1\|4210886_4214120_+\|molecular-chaperone-Hsp90	unknown	unknown	unknown
NZ_CP016824.1\|WP_067414597.1\|4204707_4205604_-\|1,4-dihydroxy-6-naphthoate-synthase	unknown	unknown	gnl\|CDD\|270353
NZ_CP016824.1\|WP_107436690.1\|4215297_4216476_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP016824.1\|WP_067414572.1\|4188428_4189484_-\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NZ_CP016824.1\|WP_067414584.1\|4194327_4195305_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP016824.1\|WP_067414574.1\|4190502_4191189_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NZ_CP016824.1\|WP_067414577.1\|4192382_4193480_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NZ_CP016824.1\|WP_067414580.1\|4193476_4194331_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP016824.1\|WP_067414600.1\|4205671_4206397_-\|futalosine-hydrolase	unknown	unknown	gnl\|CDD\|350166
NZ_CP016824.1\|WP_030774421.1\|4206417_4206942_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_008415589.1\|4191321_4192386_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067414603.1\|4206971_4208459_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.09069e-18
NZ_CP016824.1\|WP_067414589.1\|4198481_4200377_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.04533e-83
NZ_CP016824.1\|WP_051701319.1\|4202793_4203513_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.84875e-26
NZ_CP016824.1\|WP_067414586.1\|4195522_4198102_+\|protein-kinase/lanthionine-synthetase-C-family-protein	gnl\|CDD\|271199	cd04791, LanC_SerThrkinase, Lanthionine synthetase C-like domain associated with serine/threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown.	1.50433e-91
NZ_CP016824.1\|WP_008415578.1\|4198191_4198323_+\|SapB/AmfS-family-lantipeptide	gnl\|CDD\|380211	NF033212, SapB_AmfS_lanti, SapB/AmfS family lantipeptide. Members of this family are class III lantipeptide precursors. These typically are short peptides, encoded next to the gene for the lantipeptide synthetase that creates the characteristic lanthionine (or beta-methyl lanthionine) bridges for which these natural products are named. Members of this family include SapB and AmfS, which are considered morphogens rather than antibiotics. Members also include labionin-containing peptides such labyrinthopeptins A1 and A2.	5.06968e-12
NZ_CP016824.1\|WP_067414592.1\|4200373_4202305_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	5.33189e-46
NZ_CP016824.1\|WP_008406155.1\|4208870_4209731_+\|DUF3027-domain-containing-protein	gnl\|CDD\|378605	pfam11228, DUF3027, Protein of unknown function (DUF3027). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.60749e-109
NZ_CP016824.1\|WP_003950021.1\|4204214_4204598_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	5.07314e-27
NZ_CP016824.1\|WP_107436690.1\|4215297_4216476_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	5.87456e-71
NZ_CP016824.1\|WP_067414597.1\|4204707_4205604_-\|1,4-dihydroxy-6-naphthoate-synthase	gnl\|CDD\|270353	cd13635, PBP2_Ttha1568_Mqnd, A menaquinone biosynthetic enzyme exhibits the type 2 periplasmic-binding protein fold. This group includes Ttha1568 (MqnD) from Thermus thermophilies HB8, an enzyme within an alternative menaquinone biosynthetic pathway that catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate. Menaquinone (MK; vitamin K) is an essential lipid-soluble carrier that shuttles electrons between membrane-bound protein complexes in the electron transport chain. Ttha1568 has significant structural homology with the members of type 2 periplasmic-binding fold protein superfamily. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.49297e-139
NZ_CP016824.1\|WP_067414572.1\|4188428_4189484_-\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	3.82329e-49
NZ_CP016824.1\|WP_067414584.1\|4194327_4195305_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	4.89172e-73
NZ_CP016824.1\|WP_067414574.1\|4190502_4191189_-\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	4.02535e-24
NZ_CP016824.1\|WP_067414577.1\|4192382_4193480_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	1.28784e-70
NZ_CP016824.1\|WP_067414580.1\|4193476_4194331_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	4.09753e-134
NZ_CP016824.1\|WP_067414600.1\|4205671_4206397_-\|futalosine-hydrolase	gnl\|CDD\|350166	cd17766, futalosine_nucleosidase_MqnB, futalosine nucleosidase which catalyzes the hydrolysis of futalosine to dehypoxanthinylfutalosine and a hypoxanthine base; similar to Thermus thermophiles MqnB. Futalosine nucleosidase (MqnB, EC 3.2.2.26, also known as futalosine hydrolase) functions in an alternative menaquinone biosynthetic pathway (the futalosine pathway) which operates in some bacteria, including Streptomyces coelicolor and Thermus thermophiles. This domain model belongs to the PNP_UDP_1 superfamily which includes members which accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. PNP_UDP_1 includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). Superfamily members have different physiologically relevant quaternary structures: hexameric such as the trimer-of-dimers arrangement of Shewanella oneidensis MR-1 UP, homotrimeric such as human PNP and Escherichia coli PNPII (XapA), homohexomeric (with some evidence for co-existence of a trimeric form) such as E. coli PNPI (DeoD), or homodimeric such as human and Trypanosoma brucei UP. The PNP_UDP_2 (nucleoside phosphorylase-II family) is a different structural family.	1.3208e-66
NZ_CP016824.1\|WP_008415589.1\|4191321_4192386_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	8.13833e-83

>NZ_CP016824.1|WP_067414592.1|4200373_4202305_+|ABC-transporter-ATP-binding-protein
MTRPRHTDGAPSPLLRPALTFARRRKGPLGALGAWSLLESARTFLTGYAVARALDDGFLAGDVRTGLLWLLALAAAALAGGFADAGVFRALGGVIEPLRDSLVRRVVRATLTRAVASPTPADTARVSRLTAQTEIARDAAGGVLLTVRSFLFTSAGAFTGLAALSPRLLPLVLIPLAAGLALFAATLRPMAARQRDLLDADEHLAAFAGRTDHAARDIAATGAAPLVTAEAAPLITAEATAASALARWSAVRVTALGLAAHLPVATLLLAAPPLLSTGLTPGELLAALTYVTTALLPAVNALLTALGAAGSRLLVVLHRLLGEEADAADVREEQAHALRVDDGPRAPGACSQGKADDEVPAIPAPSLPPEPVHGPEPFRAEPSPPGPRPTRGPRPTRPALPAATLRGVTFAYGPDAAPVLDHLDLTVEPGEHLLVVGPSGAGKSTLLALLAGTAPPRHGQIHLAGHTARHARTLGTAARVLVPQEPYIFEAPLHDNLTYLAPNAPAPRITEAIHTFTLTPLAADPARPLRPDHLTPSERRRIALARAWLTPTPLLLLDEPTAHLDAGARAATELAFASHPATVITVSHHFPAPEPGQRVLLLDGATPYLGTHASLLRESALYGELAAGLGEPSAAGSRSTAST
>NZ_CP016824.1|WP_067414589.1|4198481_4200377_+|ABC-transporter-ATP-binding-protein
MTAAPADAARARATPAPPPAEGRLLREAVRRGRGPAALVLAATALGAAAAVTLPLALGRAVDLLIARADAGSWVLLCTALIATEVATDALVARTGGRTGAATTAWLRRRALAGFLAAPPAATTGTGLPTRLTANALDAGTAPVAAATAAAAGLAPLGGLAGLFLVDPWAGAAFVCGVPLLLLILRALLRDGRAALTTYQEEQGRMARLLTGALSGAATIAAAGTVRAEERRVLAPLAGMRAAGERTWRVQGRAAGLSGALMPLLVAAVLAVGGVRLVAGHLTPGDLLALSRYAVLAAGAGALAGALNGWVRAKAGTARVETVTALPPTPHGTRDLPPHGDGTLALHGVHVTRDGVPLLDSVTLTLPGGTTTALVGPSGSGKSLLAAVAGRLTDPDQGTVLLDGTDLRTLSADTLRHAVAYAFERPALFGATIADAVACGPLPEPDLRRALRRAAADTFTDRLPHGPRTPLPEAPLSGGELQRLGLARAFTRPTRLLILDDATSSLDTVTAHLVARALTDTPGTRLTITHRLTTAAQSDQVVWLDGGRIRGRGPHSVLWRDPAYRAVFGAGAGGDAGAGADTVTDTGARRRSDVRTDVTGDVRTELPTDMRTDIHTGIRTDPRVDTGTGAVE
>NZ_CP016824.1|WP_008415578.1|4198191_4198323_+|SapB/AmfS-family-lantipeptide
MALLDLQAMDTPQEEAVGDLATGSQISLLICEYSSLSVTLCTP
>NZ_CP016824.1|WP_067414586.1|4195522_4198102_+|protein-kinase/lanthionine-synthetase-C-family-protein
MNPEYALYSGTDRWFYDTPRRAGRAADGSGNGSDGHRYALARRPAPEGWESAERGDWFSLAPAGRQLPAQGWKIHVSATPDNAEEVLETVAGICQERATAFKFLAGPALLLHRNTKYADRAGSGKFVTVYPATTAACGALAAELADALKGSAGPVVLSDLRWGEGPVHVRYGAFAPRFTRAADGSLVPAVADPAGRLVPDTRGPAFRLPDWVALPDFLRPHAEARAAQGTTDLPYTVERALHFSNGGGVYAGSHRETGEAVVLKEGRPHAGLAADGVDAVTRLEREYAALRALEGLACVPRVHGLHTVGEHRFLAMEFIPGTPLNTVFARRFPLSAAEPAAEALAEHTAWALRTHQLVTEAVEALHARGIAFGDLHMNNIMVAPDQLSVTLLDFEAATPAAERRPQIVANPAFVAPPHLRGTEVDRYALACLRLALFVPLTTLLPLDRDKAAHLAGLAADRYGIDRALFDEAVTELAGPARPEAGTSRGRPPVSATDWPAARDSMVAALLASATPDRDDRYFPGDIAQFATPAGGQSYGYGAAGVLHALHTVGARCEEAEEWLIRTTRRPASGTPTGFYDGLTGIAWTLDRLGHREEALRLAHLVAAEPLDALGPGLHSGAPGVALALRDLADATDNPALGQAADRAEAAALRPAAPGGKAGLLHGPAGTALLCLRRHARTGEAALLDTAATALREELGRCVPGPDGSLVVSEARRTMPYLGSGSAGIAMVLDDYLAHRPDPAFEEARTALLRATGSAFYIQPGLFRGVAGLLLHLARTTTPGDRAARTALLTRQTALLDWHALTYQGHLAHPGEQLTRLSMDLSTGTAGVLLALAATHGEPAAHLPFLPPLRRPTDRP
>NZ_CP016824.1|WP_067414584.1|4194327_4195305_+|iron-siderophore-ABC-transporter-substrate-binding-protein
MTRRTARPLLAATGALALALTLTACGSGEETAADAGKDAGATRTVKTAMGEVEVPEAPKRVVVLDTAELDSALTLGVKPVGAVRSDAAGGFASYLPEKELAGIENVGVIAQPNLEAIAALKPDLILTSKVRDEARYAQLSKIAATVMTENTGYPWKENFQVHAEALGKQKEADRATAAYEKRTAEVTEAVGGPAEAEKTEVNVVRFVEGADIRIYGRKNYIGTLLADVGLGRPAITDKATDGFSYDVSPEKIDLADADVVFTATYGDPEKAKETQTTRSALWRSLDAVKSGAVHKVEDELWIQGIGYTAAQQILDELEEALTSAS
>NZ_CP016824.1|WP_067414580.1|4193476_4194331_+|ABC-transporter-ATP-binding-protein
MTRPAARLTARDLTLAYEDRTVVPGLNLDIPDGRVTVIIGPNACGKSTTLRALGRLLRPAGGAVLLDGAELARLPTRQIARQVGLLPQTPVAPEAITVADLVARGRQPHQRWWQQWSEEDERAVTEAMARTATTDLADRPVDALSGGQRQRVWIAMALAQETGLLLLDEPTTYLDLAHQVEVLDLVRRLNREQGRTVVLVLHDLNQAARYADHLIAFREGRVVAEGAPAEVVTAGLVREIFGLECVVVPDPVTGSPLVVPGAPWDARPAPEPAVPTREESRATP
>NZ_CP016824.1|WP_067414577.1|4192382_4193480_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MSGGSVVLKAGPEPARVRPAGYVPVRVGPASLLVPVRAVATGAVLAGVLAVVCVAYLSVGESFVAPGSVVDVLLGRPSPDTLVVGELRLPRMVAGLYVGAAFGIAGALIQTVARNPLASPDLIGVSQGASAATVAALIFGVTSYTVLPWISVGAGPLAALLVYLFAWRGGLQATRFVLVGVGFAVALRALTTLFLTKGDQTVAQQAQVWMSGSLNGRAWPEAALVGWTLLAALPALVWAARAQRTVTLDDATATSLGARLGRARLGLVLVGVVLASVATGAAGPVDFVALLAPQIARRLARTAQIPLVCSALAGAVTVVAADLLARRLFAPTELPVGVLTAAVGAPYLIWLLVTRHGPRATGGTS
>NZ_CP016824.1|WP_008415589.1|4191321_4192386_+|iron-ABC-transporter-permease
MPPAPPAAPSPAKAPPTAPRPRRDSAVRRAAWTVAALVALLVAVVLSLAVGARTVAPGTVVEALFQGATGPDAEVVREMRLPRTLIGVMVGAALAVAGTALQGITRNPIADPGILGISQGASVGVVLAIAFAGVHTLAGYVWFAFVGAGLAAVAVYAVAAGGRGGATPVKLALSGAAINALLVSVTTAVLTTSSSALDEFRFWNVGALQGRGADVAVQVWPFLLVGLALVASSARGLDALALGEDVAKGLGQRVAAVRITAGAGAAVLTGVGVAAAGPVAFVGLAVPHLVRHLVGGDHRWVLPLAALTGPVMLLASDTVGRVLFPPGEVPAGVMTALIGVPFLVALVRSRAVTA
>NZ_CP016824.1|WP_067414574.1|4190502_4191189_-|HAD-family-hydrolase
MPEHLTSAAAPAPSDPAVPAARPVPGGAGPVVGFDLDMTLIDSRPGIGAAYRVLAAETGVLIDVDLVVSRLGPPLETELACWFPAEQVPAAAARYREVYPTTAIAPSLALPGAAAALEAVRAHGGRSLVVTAKNEEHARLHLDHLGLRADLVVGSLWAEAKGGALRAQGATVYVGDHVGDVRGARAAGAFSVAVATGGCTPDELRTAGADLVLPDLTAFPAWLAEFAR
>NZ_CP016824.1|WP_067414572.1|4188428_4189484_-|YihY/virulence-factor-BrkB-family-protein
MKQPARTAGGAVAEEARTVEGVEGDGPVKGEPGRTVEWWVALRRTPGAFWRDDVSDFAAALTYYAILAVLPALLVVVIAFGLVSPDTAERFVGQVTAWAPGGSGASLREVLTRVVRVDSTAWTLLVTGGASALWSASSYLAVSRRALHRMYGVRDRRSPWGKAHRIVATALALLALLLVSSLLLMLTEPVAESIGRLLGLDAGVAWAWSVLRWPLLLCLVACLVVVVFRNGPVAARRRAHSIPGGVLAATLWLTASAGLALYASVLSTYSRLYGSLAGIVVFLVWLWLSNVALLLGAQFTAELCRAAGGPGAPACHPEPAEEVAAQDTSAGAEDAADAEETREHGRAPTGA
>NZ_CP016824.1|WP_051701319.1|4202793_4203513_-|response-regulator-transcription-factor
MIHSSGVLRSALVALLERERFQVTSASGFSRASSGTTGATGAPGTPGAPATVTVVDGSCPVGAAHLERRSLQGSAKEPTHATPALAAARPGLGLAGAGAERAGIGLAGASRGRAALVVLAGAEHPGVLRLAYAAGALGLVDRDGPANHLATAIRLAAGGGRYVDDGLAMSLLRAMDMPLSPREVRVLSRAAQGDSVAEIARGLCLSHGTVRNYIASATRKVGARNRVDAIRISRAAGWV
>NZ_CP016824.1|WP_067414595.1|4203821_4204073_-|hypothetical-protein
MSDTTQQTPAPGDRFVKTGGIVFIIGALATLVTVAPLFLGSDPFPTAAYLVSMLMGVGFLIAGAGLVRQIAAQRRETRAAVEG
>NZ_CP016824.1|WP_003950021.1|4204214_4204598_+|cold-shock-protein
MPTGKVKWFNSEKGFGFLSRDDGGDVFVHSSVLPAGVEALKPGQRVEFGVVAGQRGDQALSVVLLDPAPSVAAAQRRKPDELASIVQDLTTVLENVSRSLERGRYPDRASGAKVAGMLRAVADQLDV
>NZ_CP016824.1|WP_067414597.1|4204707_4205604_-|1,4-dihydroxy-6-naphthoate-synthase
MSESGTGGGVQGTADEAGRLSIAYSPRPNDTFVFDAVAHGRVPGAPALDVTFADIDLTNGMAERGAYDVLKVSYAALPWLLDEYALLPCGGALGRGCGPLVLTREASLPGALAGRTVAVPSERSTAYLLFRLWAADQVPGGVGEIVVMPFHEIMPAVRDGKVDAGLVIHEARFTYQNYGLHKLADMGEHWEATTGLPIPLGAIIARRSLGAERLTALAQALRTSVRMAWDDPAASRPYVLAHAQEMDADVADQHIGLYVNEFTADLGEDGYAAVRGLLTRAAAEGLVPPLAPDALRFP
>NZ_CP016824.1|WP_067414600.1|4205671_4206397_-|futalosine-hydrolase
MRLLVATAVPPERDAVARAFGAPDTPEETALPGAVLLRTPGADVLAAGVGPAAAASATSAALTAARLAGNPYDLVVSAGIGGGFAERAPVGAVVVADRIVAADLGAETPDGFVPVTGLGFGTDAHVPPAALVEAAREAGLVPGAVLTVSTVTGSADRAAELLARHPSAVAEAMEGFGVAEAAAAHGVPVLEIRAISNAIGPRDRDAWRIPAALTALTSAFVRLAPAEAGSPFALARARLVP
>NZ_CP016824.1|WP_030774421.1|4206417_4206942_-|hypothetical-protein
MTSLPRGGAARQFSPAMRRGFAVLGAVSAGLLVLSACDKPTAVATVTIGSDSVNSEATCWNGGSKIDEKKLQQCLQDKGEGDSGDGAEVKTVKVDTEADVHIGVDPKIADKGWTILMNGQPLTDASNKTFRTIPGSVFFNQQYGASGDSTVLSILENDGGSATGLWSFKLEKES
>NZ_CP016824.1|WP_067414603.1|4206971_4208459_-|MFS-transporter
MRRAARVVGRALRTPVTGPARGIRKVTHAQGAGESGLGRLIELHGVNGAGDVMITVALASTVFFSVPTDEARGRVALYLAVTMLPFTLLAPVVGPLLDRLPHGRRAAMAGSMLARAVLALVLSGAVATGSLEMYPAALGVLVASKAYGVVRSAVVPRLLPQGFSLVKANSRVTLGGLLATGVAAPVGAGLQMIGPGWPLYGACLLFLGGAFLSFRLPPKVDSARGERRALLAADEQHLAAAVDARWDPVTTDDKTDSTDNKEEEKDRDRDRDRDRDRDRDRDRESRKGKEKERRRKGPGLRTVGPAVTHALAANACVRCQSGFLIFFLAFLLREHPLTGQSAAVSLAVVGVAAGAGNALGTAVGAWLRARAPEVIIVTVVGALVAVAVSAAVFFGAAVVAVLGAVAGFTQALAKLSLDALIQRDVPELVRTSAFARSETLLQMAWVVGGAIGIALPLRGPLGLSVGALIVALGWLTTVRALLASARRGASHPRVA
>NZ_CP016824.1|WP_008406155.1|4208870_4209731_+|DUF3027-domain-containing-protein
MSAATTRSRTPDRLCAEAVDLARSVAEETAAPGVVGEHLAVTADGDRVATHYFACHDPGYRGWRWAVTVARASRAKYVTVDESVLLPGPDALLAPEWVPWSERLRPGDLGPGDLLPTEADDLRLEPGWIADEEPPPNSAVSADMAELVEAEDASLSAGPPADLPLAPERGSVASVAEELGLRRSRVLSRYGLLDAAERWEAQFGAESAMAQAAPAPCVSCGFLLPLAGSLRQAFGICANAYSPADGHVVSLAYGCGGHSEAAVMPTPPRPPDPALDETRLDPLPLD
>NZ_CP016824.1|WP_067414606.1|4210886_4214120_+|molecular-chaperone-Hsp90
MTHPTPAQEGKDPFGTARRRRTVLDSWAASPARFREDANAEEDLALGGYRDRLIVELAQNAADAASRAGTDGRLRLTLHESAGTHVLAAANTGAPLDATGVESLSTLRASAKRPATGTATGAAPGAGPSVGRFGVGFAAVLAVSDEPAVLSRTGGVRWDLAQAREAAREVARHSPGLGDELIRRDDHVPLLRLPFPAEGIPPEGYDTVVVLPLRDAAAQDLAERLLAGVDDALLLALPGLTEIVVETPESTRALRRRDEEPYVVIEESTGGSGATGAGATGTPAETRRWRTATSGGPLDAPLLADRPVEERLRPYWSVVWAVPVDAEGPPVRPATAPVVHAPTPSDEPLGVPALLIASFPLDTARRHVAPGPLTDFLVARAAEAYAGLLGAWRPVGPAAVGLVPGPLGLAAVDGAVRAAVLDLLPRTAFLPPALPPAGPDEEPDTDVPLLRADRPEALRPIEAELVEGAGEATVRVLAEVLPTLLPAGLERRAELRTLGVGRLSLGEAIDRLAGVERSPAWWYRLYDSLAGVDPDRLQGLPVPLAAGSTAGSPRQVLLPGPAEDGPRPAALARLGLKVAHPEAAHPLLEKLGALPATPRAVLRTPQVRAAVAESLEGDGYALRDDAPDAEELAELVLTLARDAELAPGDEPWLGALALPDEDGELSPAGELVLPGGEFASVMREGELAAVDEEWAGRWGEQPLAACGVLARFTLVRATDVVLDPDELEPRDTDFAEPDDVGLLDAVDVWCEDVLDQLPDGPVPPVATEITAVRDLDLVDDDRWPEALALLSRPPLRDALTQPVRVLLPDGTTESVRPYTAWWLRGHPVLDGRRPAGLRAASGDALLAGLYDEVDAAGFDDALVLRALGVRTTAAALLDEPGGAAELLDRLADPDREVSARQLHALYGLLAELDPEEVTLPDELRAVADGVVTVVDARDALVADAPDLLPFAAGRSLLPVAPALAARLAELLQVGRLSEAVRVTPAGEGVEYPVPEAVRELLGDGVPASYREHDELLADGVELDWHLTASGVLHAATLEGVAAGLAWGAGQWPRRFEVAALLEDPSRRAELSRDRWFD
>NZ_CP016824.1|WP_107436690.1|4215297_4216476_-|cytochrome-P450
MHARGPATRVDVLGVPAWSVSDPALLRALLTSPDVSKDGRAHWPAFAETVQSWPLALWIAVRNMFTSYGADHRRLRRIIAPAFSARRVEAVRPVVERITAGLLDDLAALPPDAPVDLREKLAYPLPVAVIGHLMGVPEERYAHFRAVVDGVFDTTLGREEATANTGALYVVLDELIATRRAEPGDDLTSLLLTTPDEEGAEPPLSHEELRDTLLLVISAGYETTVNVIDQAVHALLTVDGQLDLVRSGRVGWGDVVEETLRHEGAVKHLPLRYAVRDIPLPDGRTIARGEAILASYAAANRHPGWHDDADVFDAGRLSKEHLAFGHGVHFCVGAPLARLEVEVCLRLLFARFPGLALDLPAEGLPPFPSLISNGHRNLPVWLHGGALGEGPG

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Crispr_ID: NZ_CP016824_25

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_25

4214947-4215208

Orphan

Consensus_repeat	Method
CAGCCCGGCCGGCGATTGAGGCCAGTCAGTGACC	PILER-CR

3 spacers

The CRISPR arrays of NZ_CP016824_25

>merge|NZ_CP016824|25|4214947-4215208|PILER-CR
CAGCCCGGCCGGCGATTGAGGCCAGTCTTTGACCGGCACGGTCGAGACGGAGCCCGGCAATCGACAGCCCGGCCGGCGTTTGAGGCCATCAGTGACCCACAGGGTCACGGCGGGCACGCAGTGGCGGACCCCAGCCCCACCGAATCCCAGCCCGGCCGGCGATTGAGGCCAATCGGGGGCCGGGCACGGGCAACAACCGGCACCCCAAGTCGCGGCGCAGCCACCCCGCAGCCCGGCCGGCGCTTGAGGCCAGTTCGTGACC

>NZ_CP016824|25|4|4214947-4215208|PILER-CR
CAGCCCGGCCGGCGATTGAGGCCAGTCTTTGACC	GGCACGGTCGAGACGGAGCCCGGCAATCGA
CAGCCCGGCCGGCGTTTGAGGCCATCAGTGACCC	ACAGGGTCACGGCGGGCACGCAGTGGCGGACCCCAGCCCCACCGAATCCC
AGCCCGGCCGGCGATTGAGGCCAATCGGGGGCCG	GGCACGGGCAACAACCGGCACCCCAAGTCGCGGCGCAGCCACCCCGCAGCCCGGCCG
GCGCTTGAGGCCAGTTCGTGACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_008404117.1\|4222618_4222882_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_008404115.1\|4223625_4224972_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP016824.1\|WP_003950032.1\|4221099_4222545_+\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NZ_CP016824.1\|WP_008406155.1\|4208870_4209731_+\|DUF3027-domain-containing-protein	unknown	unknown	gnl\|CDD\|378605
NZ_CP016824.1\|WP_067414600.1\|4205671_4206397_-\|futalosine-hydrolase	unknown	unknown	gnl\|CDD\|350166
NZ_CP016824.1\|WP_067414614.1\|4220475_4220742_-\|DUF2530-domain-containing-protein	unknown	unknown	gnl\|CDD\|378488
NZ_CP016824.1\|WP_067414592.1\|4200373_4202305_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP016824.1\|WP_051701319.1\|4202793_4203513_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP016824.1\|WP_003950021.1\|4204214_4204598_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP016824.1\|WP_067414595.1\|4203821_4204073_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_107436690.1\|4215297_4216476_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP016824.1\|WP_067414609.1\|4216903_4217764_+\|calcium-binding-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_030774421.1\|4206417_4206942_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067414616.1\|4225050_4225641_+\|RNA-2',3'-cyclic-phosphodiesterase	unknown	unknown	gnl\|CDD\|274058
NZ_CP016824.1\|WP_067414619.1\|4225860_4226856_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381313
NZ_CP016824.1\|WP_067414597.1\|4204707_4205604_-\|1,4-dihydroxy-6-naphthoate-synthase	unknown	unknown	gnl\|CDD\|270353
NZ_CP016824.1\|WP_003950034.1\|4223080_4223518_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP016824.1\|WP_067414603.1\|4206971_4208459_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP016824.1\|WP_067414606.1\|4210886_4214120_+\|molecular-chaperone-Hsp90	unknown	unknown	unknown
NZ_CP016824.1\|WP_067414611.1\|4217868_4220307_-\|HAD-IC-family-P-type-ATPase	unknown	unknown	gnl\|CDD\|319795

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_008404115.1\|4223625_4224972_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.19265e-82
NZ_CP016824.1\|WP_003950032.1\|4221099_4222545_+\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	1.89915e-107
NZ_CP016824.1\|WP_008406155.1\|4208870_4209731_+\|DUF3027-domain-containing-protein	gnl\|CDD\|378605	pfam11228, DUF3027, Protein of unknown function (DUF3027). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.60749e-109
NZ_CP016824.1\|WP_067414600.1\|4205671_4206397_-\|futalosine-hydrolase	gnl\|CDD\|350166	cd17766, futalosine_nucleosidase_MqnB, futalosine nucleosidase which catalyzes the hydrolysis of futalosine to dehypoxanthinylfutalosine and a hypoxanthine base; similar to Thermus thermophiles MqnB. Futalosine nucleosidase (MqnB, EC 3.2.2.26, also known as futalosine hydrolase) functions in an alternative menaquinone biosynthetic pathway (the futalosine pathway) which operates in some bacteria, including Streptomyces coelicolor and Thermus thermophiles. This domain model belongs to the PNP_UDP_1 superfamily which includes members which accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. PNP_UDP_1 includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). Superfamily members have different physiologically relevant quaternary structures: hexameric such as the trimer-of-dimers arrangement of Shewanella oneidensis MR-1 UP, homotrimeric such as human PNP and Escherichia coli PNPII (XapA), homohexomeric (with some evidence for co-existence of a trimeric form) such as E. coli PNPI (DeoD), or homodimeric such as human and Trypanosoma brucei UP. The PNP_UDP_2 (nucleoside phosphorylase-II family) is a different structural family.	1.3208e-66
NZ_CP016824.1\|WP_067414614.1\|4220475_4220742_-\|DUF2530-domain-containing-protein	gnl\|CDD\|378488	pfam10745, DUF2530, Protein of unknown function (DUF2530). This family of proteins with unknown function appears to be restricted to mycobacteria.	0.00196867
NZ_CP016824.1\|WP_067414592.1\|4200373_4202305_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	5.33189e-46
NZ_CP016824.1\|WP_051701319.1\|4202793_4203513_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.84875e-26
NZ_CP016824.1\|WP_003950021.1\|4204214_4204598_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	5.07314e-27
NZ_CP016824.1\|WP_107436690.1\|4215297_4216476_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	5.87456e-71
NZ_CP016824.1\|WP_067414616.1\|4225050_4225641_+\|RNA-2',3'-cyclic-phosphodiesterase	gnl\|CDD\|274058	TIGR02258, UPF0097_protein_AF_2157, 2'-5' RNA ligase. This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing].	3.57724e-36
NZ_CP016824.1\|WP_067414619.1\|4225860_4226856_-\|aldo/keto-reductase	gnl\|CDD\|381313	cd19087, AKR_AKR12A1_B1_C1, AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR). Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.	2.58568e-167
NZ_CP016824.1\|WP_067414597.1\|4204707_4205604_-\|1,4-dihydroxy-6-naphthoate-synthase	gnl\|CDD\|270353	cd13635, PBP2_Ttha1568_Mqnd, A menaquinone biosynthetic enzyme exhibits the type 2 periplasmic-binding protein fold. This group includes Ttha1568 (MqnD) from Thermus thermophilies HB8, an enzyme within an alternative menaquinone biosynthetic pathway that catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate. Menaquinone (MK; vitamin K) is an essential lipid-soluble carrier that shuttles electrons between membrane-bound protein complexes in the electron transport chain. Ttha1568 has significant structural homology with the members of type 2 periplasmic-binding fold protein superfamily. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.49297e-139
NZ_CP016824.1\|WP_003950034.1\|4223080_4223518_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.04287e-20
NZ_CP016824.1\|WP_067414603.1\|4206971_4208459_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.09069e-18
NZ_CP016824.1\|WP_067414611.1\|4217868_4220307_-\|HAD-IC-family-P-type-ATPase	gnl\|CDD\|319795	cd02609, P-type_ATPase, uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7. This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.	0

>NZ_CP016824.1|WP_067414606.1|4210886_4214120_+|molecular-chaperone-Hsp90
MTHPTPAQEGKDPFGTARRRRTVLDSWAASPARFREDANAEEDLALGGYRDRLIVELAQNAADAASRAGTDGRLRLTLHESAGTHVLAAANTGAPLDATGVESLSTLRASAKRPATGTATGAAPGAGPSVGRFGVGFAAVLAVSDEPAVLSRTGGVRWDLAQAREAAREVARHSPGLGDELIRRDDHVPLLRLPFPAEGIPPEGYDTVVVLPLRDAAAQDLAERLLAGVDDALLLALPGLTEIVVETPESTRALRRRDEEPYVVIEESTGGSGATGAGATGTPAETRRWRTATSGGPLDAPLLADRPVEERLRPYWSVVWAVPVDAEGPPVRPATAPVVHAPTPSDEPLGVPALLIASFPLDTARRHVAPGPLTDFLVARAAEAYAGLLGAWRPVGPAAVGLVPGPLGLAAVDGAVRAAVLDLLPRTAFLPPALPPAGPDEEPDTDVPLLRADRPEALRPIEAELVEGAGEATVRVLAEVLPTLLPAGLERRAELRTLGVGRLSLGEAIDRLAGVERSPAWWYRLYDSLAGVDPDRLQGLPVPLAAGSTAGSPRQVLLPGPAEDGPRPAALARLGLKVAHPEAAHPLLEKLGALPATPRAVLRTPQVRAAVAESLEGDGYALRDDAPDAEELAELVLTLARDAELAPGDEPWLGALALPDEDGELSPAGELVLPGGEFASVMREGELAAVDEEWAGRWGEQPLAACGVLARFTLVRATDVVLDPDELEPRDTDFAEPDDVGLLDAVDVWCEDVLDQLPDGPVPPVATEITAVRDLDLVDDDRWPEALALLSRPPLRDALTQPVRVLLPDGTTESVRPYTAWWLRGHPVLDGRRPAGLRAASGDALLAGLYDEVDAAGFDDALVLRALGVRTTAAALLDEPGGAAELLDRLADPDREVSARQLHALYGLLAELDPEEVTLPDELRAVADGVVTVVDARDALVADAPDLLPFAAGRSLLPVAPALAARLAELLQVGRLSEAVRVTPAGEGVEYPVPEAVRELLGDGVPASYREHDELLADGVELDWHLTASGVLHAATLEGVAAGLAWGAGQWPRRFEVAALLEDPSRRAELSRDRWFD
>NZ_CP016824.1|WP_008406155.1|4208870_4209731_+|DUF3027-domain-containing-protein
MSAATTRSRTPDRLCAEAVDLARSVAEETAAPGVVGEHLAVTADGDRVATHYFACHDPGYRGWRWAVTVARASRAKYVTVDESVLLPGPDALLAPEWVPWSERLRPGDLGPGDLLPTEADDLRLEPGWIADEEPPPNSAVSADMAELVEAEDASLSAGPPADLPLAPERGSVASVAEELGLRRSRVLSRYGLLDAAERWEAQFGAESAMAQAAPAPCVSCGFLLPLAGSLRQAFGICANAYSPADGHVVSLAYGCGGHSEAAVMPTPPRPPDPALDETRLDPLPLD
>NZ_CP016824.1|WP_067414603.1|4206971_4208459_-|MFS-transporter
MRRAARVVGRALRTPVTGPARGIRKVTHAQGAGESGLGRLIELHGVNGAGDVMITVALASTVFFSVPTDEARGRVALYLAVTMLPFTLLAPVVGPLLDRLPHGRRAAMAGSMLARAVLALVLSGAVATGSLEMYPAALGVLVASKAYGVVRSAVVPRLLPQGFSLVKANSRVTLGGLLATGVAAPVGAGLQMIGPGWPLYGACLLFLGGAFLSFRLPPKVDSARGERRALLAADEQHLAAAVDARWDPVTTDDKTDSTDNKEEEKDRDRDRDRDRDRDRDRDRESRKGKEKERRRKGPGLRTVGPAVTHALAANACVRCQSGFLIFFLAFLLREHPLTGQSAAVSLAVVGVAAGAGNALGTAVGAWLRARAPEVIIVTVVGALVAVAVSAAVFFGAAVVAVLGAVAGFTQALAKLSLDALIQRDVPELVRTSAFARSETLLQMAWVVGGAIGIALPLRGPLGLSVGALIVALGWLTTVRALLASARRGASHPRVA
>NZ_CP016824.1|WP_030774421.1|4206417_4206942_-|hypothetical-protein
MTSLPRGGAARQFSPAMRRGFAVLGAVSAGLLVLSACDKPTAVATVTIGSDSVNSEATCWNGGSKIDEKKLQQCLQDKGEGDSGDGAEVKTVKVDTEADVHIGVDPKIADKGWTILMNGQPLTDASNKTFRTIPGSVFFNQQYGASGDSTVLSILENDGGSATGLWSFKLEKES
>NZ_CP016824.1|WP_067414600.1|4205671_4206397_-|futalosine-hydrolase
MRLLVATAVPPERDAVARAFGAPDTPEETALPGAVLLRTPGADVLAAGVGPAAAASATSAALTAARLAGNPYDLVVSAGIGGGFAERAPVGAVVVADRIVAADLGAETPDGFVPVTGLGFGTDAHVPPAALVEAAREAGLVPGAVLTVSTVTGSADRAAELLARHPSAVAEAMEGFGVAEAAAAHGVPVLEIRAISNAIGPRDRDAWRIPAALTALTSAFVRLAPAEAGSPFALARARLVP
>NZ_CP016824.1|WP_067414597.1|4204707_4205604_-|1,4-dihydroxy-6-naphthoate-synthase
MSESGTGGGVQGTADEAGRLSIAYSPRPNDTFVFDAVAHGRVPGAPALDVTFADIDLTNGMAERGAYDVLKVSYAALPWLLDEYALLPCGGALGRGCGPLVLTREASLPGALAGRTVAVPSERSTAYLLFRLWAADQVPGGVGEIVVMPFHEIMPAVRDGKVDAGLVIHEARFTYQNYGLHKLADMGEHWEATTGLPIPLGAIIARRSLGAERLTALAQALRTSVRMAWDDPAASRPYVLAHAQEMDADVADQHIGLYVNEFTADLGEDGYAAVRGLLTRAAAEGLVPPLAPDALRFP
>NZ_CP016824.1|WP_003950021.1|4204214_4204598_+|cold-shock-protein
MPTGKVKWFNSEKGFGFLSRDDGGDVFVHSSVLPAGVEALKPGQRVEFGVVAGQRGDQALSVVLLDPAPSVAAAQRRKPDELASIVQDLTTVLENVSRSLERGRYPDRASGAKVAGMLRAVADQLDV
>NZ_CP016824.1|WP_067414595.1|4203821_4204073_-|hypothetical-protein
MSDTTQQTPAPGDRFVKTGGIVFIIGALATLVTVAPLFLGSDPFPTAAYLVSMLMGVGFLIAGAGLVRQIAAQRRETRAAVEG
>NZ_CP016824.1|WP_051701319.1|4202793_4203513_-|response-regulator-transcription-factor
MIHSSGVLRSALVALLERERFQVTSASGFSRASSGTTGATGAPGTPGAPATVTVVDGSCPVGAAHLERRSLQGSAKEPTHATPALAAARPGLGLAGAGAERAGIGLAGASRGRAALVVLAGAEHPGVLRLAYAAGALGLVDRDGPANHLATAIRLAAGGGRYVDDGLAMSLLRAMDMPLSPREVRVLSRAAQGDSVAEIARGLCLSHGTVRNYIASATRKVGARNRVDAIRISRAAGWV
>NZ_CP016824.1|WP_067414592.1|4200373_4202305_+|ABC-transporter-ATP-binding-protein
MTRPRHTDGAPSPLLRPALTFARRRKGPLGALGAWSLLESARTFLTGYAVARALDDGFLAGDVRTGLLWLLALAAAALAGGFADAGVFRALGGVIEPLRDSLVRRVVRATLTRAVASPTPADTARVSRLTAQTEIARDAAGGVLLTVRSFLFTSAGAFTGLAALSPRLLPLVLIPLAAGLALFAATLRPMAARQRDLLDADEHLAAFAGRTDHAARDIAATGAAPLVTAEAAPLITAEATAASALARWSAVRVTALGLAAHLPVATLLLAAPPLLSTGLTPGELLAALTYVTTALLPAVNALLTALGAAGSRLLVVLHRLLGEEADAADVREEQAHALRVDDGPRAPGACSQGKADDEVPAIPAPSLPPEPVHGPEPFRAEPSPPGPRPTRGPRPTRPALPAATLRGVTFAYGPDAAPVLDHLDLTVEPGEHLLVVGPSGAGKSTLLALLAGTAPPRHGQIHLAGHTARHARTLGTAARVLVPQEPYIFEAPLHDNLTYLAPNAPAPRITEAIHTFTLTPLAADPARPLRPDHLTPSERRRIALARAWLTPTPLLLLDEPTAHLDAGARAATELAFASHPATVITVSHHFPAPEPGQRVLLLDGATPYLGTHASLLRESALYGELAAGLGEPSAAGSRSTAST
>NZ_CP016824.1|WP_107436690.1|4215297_4216476_-|cytochrome-P450
MHARGPATRVDVLGVPAWSVSDPALLRALLTSPDVSKDGRAHWPAFAETVQSWPLALWIAVRNMFTSYGADHRRLRRIIAPAFSARRVEAVRPVVERITAGLLDDLAALPPDAPVDLREKLAYPLPVAVIGHLMGVPEERYAHFRAVVDGVFDTTLGREEATANTGALYVVLDELIATRRAEPGDDLTSLLLTTPDEEGAEPPLSHEELRDTLLLVISAGYETTVNVIDQAVHALLTVDGQLDLVRSGRVGWGDVVEETLRHEGAVKHLPLRYAVRDIPLPDGRTIARGEAILASYAAANRHPGWHDDADVFDAGRLSKEHLAFGHGVHFCVGAPLARLEVEVCLRLLFARFPGLALDLPAEGLPPFPSLISNGHRNLPVWLHGGALGEGPG
>NZ_CP016824.1|WP_067414609.1|4216903_4217764_+|calcium-binding-protein
MRIRATVAVVSGALALSALTGAAAQAAPGPDRERIQVPTAESVFGKQATAKGKGFKAAAVPKISKVTVNGGKDIVLGTTKAKTFSVSITASHASNIGDAYAYFWHGSTYETADGVFIPNEEYASCKASSATTSTCKLTFTVDPQWELINDLAGSWNVGVGALAADDSDFAWNDKHSKTRVQRYSKLVVNATPEPVKKGKTLTVNGTLSRANWDTWKYAGYTQQSVKLQFKKKGAASYTTVKTVKSGSKGALKTTVKAASDGYWRWSFASTSTTPAINSTADFVDVK
>NZ_CP016824.1|WP_067414611.1|4217868_4220307_-|HAD-IC-family-P-type-ATPase
MTQRGQVDTGGSDSGNSRIDTGAEPDAAPPAVPPEPGLTSAEVAEAVARGEVNDVPVRSSRSLAEIARANIFTRFNAIIGVLWVIMLFVAPIQDSLFGFVIVANTGIGIFQEWRAKRTLDGLAVIGEAKPTVRRDGRPGEISTSEIVLGDLIEIGPGDKIVVDGEVREADGLEVDESLLTGEADPVVKRPGDEVMSGSFVTAGGGAFRATKVGREAYAAQLAEEASRFTLVHSELRSGISTILKYVTWMMVPTAIGLVVSQLVVRDNDFKNAVARTVGGIVPMAPEGLVLLTSVAFAIGVIRLGRKQCLVQELPAIEGLARVDTVCLDKTGTLTEGGMDVQAIRPLGGADEAYVRRVLGALGAGDPRPNASLQAVIDACPAPEGWRTTGTLPFSSARKYSGASLDEGDATHRTWLLGAPDVLLRPGAEALAETDALNERGLRVLLLSRAAGGLDGPDPGAGAEPTALVVLEQRLRPDAADTLRYFEDQHVAAKVISGDNAVSVGAVAGKLGLPGAERTYDARKLPKEPEALADTLDENTVFGRVTPQQKRDMVGALQAHGHTVAMTGDGVNDVLALKDADIGVSMGSGSEATRAVAQIVLLNNSFSTLPSVVAEGRRVIGNITRVATLFLVKTVYSVLLAILVVLSQTEYPFLPRHLTLLSTLTIGVPAFFLALAPNKERAQPHFVKRVMRYAIPGGVIAALATFTTYMTARAYYTGPDSLPAETSAATLTLFLVSLWVLAIIARPYTWWRVGLVATMAGAFLVVLAVPWLQDFFALRLVGSVMPWAAVGIAVIAAALIEVVWRLVDRRLPV
>NZ_CP016824.1|WP_067414614.1|4220475_4220742_-|DUF2530-domain-containing-protein
MKKWTPRHEAPEPLEGPVVATITGGTILWFVLFLAQLPFYGWYDDHGHTWWIWTCLAGAGLGCLGIWYVRRREAALKRAATAAPQPGS
>NZ_CP016824.1|WP_003950032.1|4221099_4222545_+|NCS2-family-permease
MPTSAPAQDATSEQPNPPSGALDRYFKITERGSTLSREVRGGFATFFAMAYIIVLNPIILGSAKDMYGHQLDNGQLVTATVLTAALTTLLMGVIGNVPVALAAGLGVNTVVALQLAPRMSWPDAMGMVVLAGFVVMLLVATGLRERVMSAVPLGLRKGIAIGIGLFIMLIGLVDAGFVSRIPDAAQTTVPLQLGADGHLNGWTVLVFVLGVLLTLALMVRKVPGAILISIVAMTVLALIINAVADIPSWGLTTPEWPGNPVATPDFGLIGQVSLFGGFAKVGLLTGILFVFTVLLSCFFDAMGTIMAVGDEAELTDAQGNMPGINKVLFVDGIAVAAGGASSSSATTCFVESTAGVGEGARTGFANIVTGGLFAIGLFLTPVVTMVPSQAATPALVAVGFLILSGSIGAIDWTDFTIAIPAFITFMMMPFTYSITNGIGMGFISFCVLRLAAGRGRSVPAAMYVVSGVFAFYYLMPALGLT
>NZ_CP016824.1|WP_008404117.1|4222618_4222882_-|hypothetical-protein
MDTHVLSLRMDSELFERLRGHAARRGMSVQDYVVRTMIRDDFDQRFQTAVEETEKFYGDEDGGAPGAGEVAEEPARDGAVNGAARPT
>NZ_CP016824.1|WP_003950034.1|4223080_4223518_+|MarR-family-transcriptional-regulator
MPDLTHGEDADAVNALRSSVMRLSRRLKHQRVDESLSPTEMSVLGTLARCGTATPGELARKEHVQPPSMTRIVALLEAKGLVRLEPHPEDRRQKVVTQTEEAEAMLEESRSKRNAWLASLAAELDEEEWAKVRAAAPVLEKLAHL
>NZ_CP016824.1|WP_008404115.1|4223625_4224972_+|MFS-transporter
MSTGPGADSAPAPAAHDSTPPAPKQSMFSSLKIHNYRLFFTGQVISNTGTWMQRIAQDWLVLTLTGSSAAVGVTTALQFLPMLLFGLYGGVLVDRLPKRPLLLFTQSAMGLTGLALAALTLTGHVQVWHVYVTAFVLGLVTVVDNPARQTFVSEMVGPRQLANAVSLNSANFQSARLVGPAVAAVLISAVGSGYAFLINGLSFAAPIAGLLMMRMGDLHKAPRTPRGKGQLREGLRYVAGRPDLIWPIVLVGFIGTFGFNFPIWLSAFADKVFDGGPGMYGTLNTLIAAGSLAGALLAARRGAGRLRLLVAAAAAFGVLEIVAAFAPSVWIFAVLMVLTGMFGLTVNVTANSYVQMATEPQMRGRVMALFMMVFTGGTPLGAPLLGWITDEYGARTGFAVGGAISLLAALAVGLILARVGGLKVKVDLRRGRKHIRFVPDEKRLAPAA
>NZ_CP016824.1|WP_067414616.1|4225050_4225641_+|RNA-2',3'-cyclic-phosphodiesterase
MASPAPRPRLFVAVVPPDAVLAELRRATAALDALPGAGRLRPTEAGGRHVTLAFLGACDPGRLDGLAARLARAAHRTAPFPLALRGAGHFGDRVLWARPDGDLDALARLADRVRAAATRAGLPPDAEHAFQPHLTLARVRPGPPLRLASFAEALAQLAAGPWQADEVRLVRSVPPPGGVPGARPAYATEGRWPLGG
>NZ_CP016824.1|WP_067414619.1|4225860_4226856_-|aldo/keto-reductase
MKYTQLGRTGLKVSRLVLGTMNFGPKTGEAESHALMDTALDDGINFFDTANVYGWGENKGRTEEILGTWFAQGGDRRDKVVLATKVYGNMGADGTAWPNHDRLSALNIRRAVDASLRRLQTDHIDLYQFHHVDRRTPFDEIWQAMDTLVQQGKILYAGSSNFPGYKIAQANEAAARRGSLGLVSEQCLYNLAERRAEMEVIPAAEEYGLGVIAWSPLHGGLLGGAIRKEREGGGSRTNDGRSGDALANSTIRAQVQAYEDLLEKHGLEPGEVALAWLLTRPGLTGPIVGPRTDEQLASAVRAVELELPQELLTALDEIFPGPGPSPEAFAW

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Crispr_ID: NZ_CP016824_26

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_26

4595239-4595340

Orphan

Consensus_repeat	Method
CGGCGGCGGCTTCGGCGGCATCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_26

>merge|NZ_CP016824|26|4595239-4595340|CRISPRCasFinder
CGGCGGCGGCTTCGGCGGCATCCTCGCCGGGGCGCGGCTGCGCCGGCAGGGCGTGGAGCGCGTCCGCATCGTGGAGACCGGCGGCGGCTTCGGCGGCACCTG

>NZ_CP016824|26|22|4595239-4595340|CRISPRCasFinder
CGGCGGCGGCTTCGGCGGCATCCT	CGCCGGGGCGCGGCTGCGCCGGCAGGGCGTGGAGCGCGTCCGCATCGTGGAGAC
CGGCGGCGGCTTCGGCGGCACCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_010642895.1\|4601361_4601877_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067415155.1\|4596864_4597374_+\|CGNR-zinc-finger-domain-containing-protein	unknown	unknown	gnl\|CDD\|378696
NZ_CP016824.1\|WP_075986466.1\|4589706_4590846_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	unknown	unknown	gnl\|CDD\|235674
NZ_CP016824.1\|WP_067415164.1\|4601891_4602740_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP016824.1\|WP_018895286.1\|4588960_4589509_-\|GtrA-family-protein	unknown	unknown	gnl\|CDD\|377229
NZ_CP016824.1\|WP_031178248.1\|4593770_4594793_-\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|225921
NZ_CP016824.1\|WP_026235455.1\|4600179_4600647_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_044474806.1\|4590884_4591385_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl\|CDD\|376377
NZ_CP016824.1\|WP_030769811.1\|4602871_4604512_+\|catalase	unknown	unknown	gnl\|CDD\|163710
NZ_CP016824.1\|WP_067415150.1\|4593205_4593757_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP016824.1\|WP_067415147.1\|4592686_4593043_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|380093
NZ_CP016824.1\|WP_067415158.1\|4597398_4598742_-\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NZ_CP016824.1\|WP_010642898.1\|4600697_4600931_-\|DUF397-domain-containing-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003950395.1\|4591395_4592613_+\|membrane-dipeptidase	unknown	unknown	gnl\|CDD\|366534
NZ_CP016824.1\|WP_067415144.1\|4587706_4588945_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP016824.1\|WP_030769808.1\|4604594_4605347_-\|tellurium-resistance-protein-TerA	unknown	unknown	gnl\|CDD\|226595
NZ_CP016824.1\|WP_067415161.1\|4601135_4601390_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_033239677.1\|4598954_4600112_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NZ_CP016824.1\|WP_030307946.1\|4584957_4586448_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|273342
NZ_CP016824.1\|WP_003950390.1\|4586976_4587654_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067415155.1\|4596864_4597374_+\|CGNR-zinc-finger-domain-containing-protein	gnl\|CDD\|378696	pfam11706, zf-CGNR, CGNR zinc finger. This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	1.02199e-17
NZ_CP016824.1\|WP_075986466.1\|4589706_4590846_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	gnl\|CDD\|235674	PRK06019, PRK06019, phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed.	5.24824e-179
NZ_CP016824.1\|WP_067415164.1\|4601891_4602740_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.21959e-08
NZ_CP016824.1\|WP_018895286.1\|4588960_4589509_-\|GtrA-family-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	1.46764e-24
NZ_CP016824.1\|WP_031178248.1\|4593770_4594793_-\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|225921	COG3386, COG3386, Gluconolactonase [Carbohydrate transport and metabolism].	5.10136e-25
NZ_CP016824.1\|WP_044474806.1\|4590884_4591385_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl\|CDD\|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	9.60722e-86
NZ_CP016824.1\|WP_030769811.1\|4602871_4604512_+\|catalase	gnl\|CDD\|163710	cd08154, catalase_clade_1, Clade 1 of the heme-binding enzyme catalase. Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes, which is involved in the protection of cells from the toxic effects of peroxides. It catalyzes the conversion of hydrogen peroxide to water and molecular oxygen. Catalases also utilize hydrogen peroxide to oxidize various substrates such as alcohol or phenols. Clade 1 catalases are found in bacteria, algae, and plants; they have a relatively small subunit size of 55 to 69 kDa, and bind a protoheme IX (heme b) group buried deep inside the structure. They appear to form tetramers. In eukaryotic cells, catalases are located in peroxisomes.	0
NZ_CP016824.1\|WP_067415150.1\|4593205_4593757_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.36915e-08
NZ_CP016824.1\|WP_067415147.1\|4592686_4593043_-\|VOC-family-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	2.80748e-24
NZ_CP016824.1\|WP_067415158.1\|4597398_4598742_-\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NZ_CP016824.1\|WP_003950395.1\|4591395_4592613_+\|membrane-dipeptidase	gnl\|CDD\|366534	pfam01244, Peptidase_M19, Membrane dipeptidase (Peptidase family M19).	3.01559e-140
NZ_CP016824.1\|WP_067415144.1\|4587706_4588945_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.47702e-30
NZ_CP016824.1\|WP_030769808.1\|4604594_4605347_-\|tellurium-resistance-protein-TerA	gnl\|CDD\|226595	COG4110, COG4110, Uncharacterized protein involved in stress response [General function prediction only].	6.07119e-35
NZ_CP016824.1\|WP_033239677.1\|4598954_4600112_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0
NZ_CP016824.1\|WP_030307946.1\|4584957_4586448_-\|MFS-transporter	gnl\|CDD\|273342	TIGR00924, putative_Di/Tri_peptide_transporter, amino acid/peptide transporter (Peptide:H+ symporter), bacterial. The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines].	0
NZ_CP016824.1\|WP_003950390.1\|4586976_4587654_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	9.19407e-84

>NZ_CP016824.1|WP_031178248.1|4593770_4594793_-|SMP-30/gluconolactonase/LRE-family-protein
MRRTTLRSLAGIAALTTLALTGCGTQQGLADDSPAAAGPAERTITAKRLARLTQPHEQTGMTLLEGPLLDAKGRLLVVDVTAPAGEPKMIRVDVRTGKGTPFHTDERGAYTSAQYSPHDGRIYLTDYAHGEIVSLAPGGGDRQVFFTGKVDGAAMHPDDLAFDRSGNLYVSDSRGLSEGTAEGRVVRISRDGKKATVLADQLAATNGISFDAEYRGLWFSELTENRISYLRLDDQGEVTSRHTAIRVDGGLAQTDSIAVDADGNLYQGLHGRAAMAVYDRHGARLATVEVPARHRGLESATNVAITPGGTRAYLTVSGPAGGYVYTFDALAEGIRQSNGG
>NZ_CP016824.1|WP_067415150.1|4593205_4593757_+|helix-turn-helix-transcriptional-regulator
MNQGPRAAARNRAALVAAAREVYAELGLDAPMAEIARRAGVGQGSLYRHFPDRDAVVATVLEENVLQVEQAAAAEGATLADVLAVLTWHLVESAAFIGLLRAEYATVRREELGRAGELGERVERALRGVLCDRGPLPAGSLMLAVAMVSGAVTGPTREDRERRALEAWALLGVEVGPVRPVPG
>NZ_CP016824.1|WP_067415147.1|4592686_4593043_-|VOC-family-protein
MPIATLDVVVLDTPAPLALATFYQAVLGGTVEQPADYWVELHGPGVKLAFQKAPDMVPPTWPSPDNSQQFHLDLNVPDLEAAESQVLALGARPLDTRPDRSFRVYADPSGHPFCLCRQ
>NZ_CP016824.1|WP_003950395.1|4591395_4592613_+|membrane-dipeptidase
MTSTPTGPVPNAELLPTALEFLAEHPVVDGHNDLPWALREQVRYDLDRRDIAEDQSAHLHTDIARLRAGGVGAQFWSVYVRSDLGGDEAVSATLEQIDCVDQLLARYPADLAPAETADAMEKARTEGRIASLKGAEGGHSINNSLATLRALHALGVRYMTLTHNDNIAWADSATDTERLGGLSAFGREVVREMNRTGMLVDLSHVSAGTMRDALATSEAPVIFSHSSSRAVCDHPRNIPDDVLAQLPANGGVAMATFVPKFILPAAVEWTLRADENLRAHGHHHLDTGEEAMALHRAFEAAHPRPVATAATVADHLDHMREVAGVDHIGIGGDYDGTAFTPAGLEDVAGYPNLVAELLSRNWSTADLAKLTWGNAVRVLRDAEAVSRDLAARRGPSNATLEQLDG
>NZ_CP016824.1|WP_044474806.1|4590884_4591385_+|5-(carboxyamino)imidazole-ribonucleotide-mutase
MGSDSDWPVMEAAAQALDEFELPYEVDVVSAHRMPHEMIAYGEQAAGRGLKAVIAGAGGAAHLPGMLASVTPLPVIGVPVPLKYLDGMDSLLSIVQMPAGVPVATVSVGGARNAGLLAARILAAHDEELLGRMKEFQRELNEQATEKGKRLRAKTAGGPAGFGFGK
>NZ_CP016824.1|WP_075986466.1|4589706_4590846_+|5-(carboxyamino)imidazole-ribonucleotide-synthase
MTFPVVGMVGGGQLARMTHEAGIPLGIRFKLLSDTPQDSAAQVAGEVVVGDYRDLETLRAFARGCDVITFDHEHVPTEHLRALEADGIPVRPGPDALVHAQDKGVMRARLTEIGAPCPRHRIVADPADVAAFAEEGDGFPVVLKTVRGGYDGKGVWVVRSEADAAEPFRAGVPVLAEEMVPFRRELAANIVRSPHGQAVAYPVVESRQVDGVCDTVIAPAPGLSEELSGQAQELALRIADELGVVGHLAVELFETEDGRVLVNELAMRPHNSGHWTMDGAVTSQFANHVRAVLDLPLGDPRPRAPWTVMCNVLGGDYPDMYAAYLHCMARDPQLKIHMYGKDVKPGRKVGHVNTYGDDLDAVLERARHAAGYLRGTITE
>NZ_CP016824.1|WP_018895286.1|4588960_4589509_-|GtrA-family-protein
MSPAPGEPTPAATAPGASALRERVRRLVREVAKFGAVGGAGVLVNLAVFNLVRHLTELQVVRASVLATVVAIVFNYLGFRYFTYRDRDKGGRTREMSLFLAFSVIGLVIENGILYTGTYGLGFDGRLESNVLKFAGIGVATLFRFWSYRTWVFRAPAAVRAAKQAAEPVREPVASGTSAGRS
>NZ_CP016824.1|WP_067415144.1|4587706_4588945_+|HAMP-domain-containing-histidine-kinase
MRRRLINSTLAVVLVVIAVFGGTLVIVETRTITNSAQESVESEALRLASIVDSRLISEERISAGLLQDQIAAKRYARIDIPGRAAIEIGERPDGDVIEARATGEEGESVLVQEPRAAVTGEVGRTLMIIGGVALLAVVAAVLLAVRQGNRLAAPLTDLAETAERLGSGDPRPRHKRYGVPELDRVADVLDGSAERIARMLTAERRLAADASHQLRTPLTALSMRLDEITLTEDLETVREEATIALAQVERLTDVVERLLTNARDPRTGSAVAFDLYEVVKQQLEEWRPAYRSEGRAIVCSGRRDLRAVATRGAVAQVLAALIENSLMHGGGTVALRTRVTGNQAVVEVADEGPGVPADLGARIFERTISGRNSTGIGLAVARDLAEADGGRLELLQPQPAVFGLFLSRAPED
>NZ_CP016824.1|WP_003950390.1|4586976_4587654_+|response-regulator-transcription-factor
MTRVLLAEDDASISEPLARALRREGYEVEVRQDGPTALDAGLRGGVDLVVLDLGLPGMDGLEVARRLRSDGHTVPILILTARADEVDTVVGLDAGADDYVTKPFRLAELLARVRALLRRGAAEPPQPTATHGVRIDVESHRAWMGDEELQLTAKEFDLLRVLVRDAGRVVTRDQLMREVWDTTWWSSTKTLDMHISWLRKKLGDDAANPRYIATVRGVGFRFEKS
>NZ_CP016824.1|WP_030307946.1|4584957_4586448_-|MFS-transporter
MASSLTKDAAGNPGSQKTFFGHPRGLATLFLTEMWERFSYYGMRALLPLYLIAPGGLALDAATATVIYSVYMATVYLLTLPGGWFGDRYWGPRKTVAIAASIVMLGHLTLALPGDAVFYVGLVLVAIGSGLLKANISTMVGHLYDGPNDPRRDGGFTVFYMGINIGAFAAPLVIGTVGENVGWHWGFGLAALGMGLGLLQFLLAGKTLSPRSSEVPKPLSSDERNNVIRKSLIWLLIAVVFYGIVGFSGSFTIKWATVPLTILGLVIPIMVLGRMKRDKELTGTEQSKLSAYVWFFIAAAVFWMIYDQGGSTLAIFADGKVDNQVFGWEFPVSWFQSVNPILVMALAPVFAWIWLYLNKKGKEPSTITKFAGGLTLVGISFFVFLLPLTASSDGSLVNPWWLVVIYFCQTVGELMLSPVGLSVTTKMAPAKYASQMMGVWFLAVTAGDSVTGLLSDSGVDLNRTGVVALEAALAVVGGFAIFMYRRKVKSLMGEIH
>NZ_CP016824.1|WP_067415155.1|4596864_4597374_+|CGNR-zinc-finger-domain-containing-protein
MARPSAPGPLVLVQDLVNTLDLETGADTLATEEGRAAFGLREADVAAARALREALRAACLAHAGHGAPAEVAALGTLLARAPLVTTVDPADGSARLAPADPDSLTARVAAAVARGSLDGSWQRLKACEDETCRWAYYDRSPAGRGRWCSMEVCGARAKMRAYRARRAGE
>NZ_CP016824.1|WP_067415158.1|4597398_4598742_-|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MALRITVIGTGYLGATHAAAMAELGFEVLGLDVVPEKIALLSQGRVPMYEPGLEELLGKHVAGIEGSSGRLRFTTSFEEVADFGDVHFVCVNTPQKPGEYACDMSYVESALASLAPHLKRPALVVGKSTVPVGSAERLASELAAAAPVGEEAELAWNPEFLREGFAVDDTLHPDRIVVGVRGARAEELLREVYRTPVAEGSPFIVTDFPTAELVKTAANSFLATKISFINAMAEVCEAADGDVAKLAEALGHDDRIGAKFLRAGIGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSVNMRRRGHMVELALEALGTTSFLGKRVAVLGATFKPDSDDVRDSPALNVAGQIHLQGGQVTVYDPKGMDNARRIFPTLGYADSALEAVRGADVVLHLTEWREFRELDPAELAAAVATPTLLDGRNALDPEVWRKAGWTFRAMGRPRA
>NZ_CP016824.1|WP_033239677.1|4598954_4600112_+|acyl-CoA-dehydrogenase
MAGAPDFDLYRLSEEHTMLRETVRALAEAKIAPHAAAVDEEARFPQEALDALTAADLHAVHVPESYGGAGADALATVLVIEEVARVCASSSLIPAVNKLGSLPVVLSGSEELKKKYLGPLAKGDGMFSYCLSEPDAGSDAAGMKTKAVRDGDFWVLNGVKRWITNAGVSEYYTVMAVTDPEKRSKGISAFVVEKGDEGVSFGAPEKKLGIKGSPTREVYFDNVRIPADRMIGEEGTGFATAMKTLDHTRITIAAQALGIAQGALDYAKGYVQERKQFGKPIGDFQGVQFMLADMAMKLEAARQLTYAAAAKSERVENDLTFFGAAAKCYASDAAMEITTDAVQLLGGYGYTRDYPVERMMRDAKITQIYEGTNQVQRIVMARNLP
>NZ_CP016824.1|WP_026235455.1|4600179_4600647_-|hypothetical-protein
MHHHGYLWAGPKERFDQEALRRPPHPEPPPAGSRPELIQRYREVAAEFPAGDLPPLETAYWLVKPPSLVRGTWGEAKEAASWLGERLAAYAPRFASAGERDVTRLARLVDAAAGQLHSGTDVSYGFYLERPTFLSLAVVTCSPNRAGPGLGCPVA
>NZ_CP016824.1|WP_010642898.1|4600697_4600931_-|DUF397-domain-containing-protein
MRNGTDLYALDIHGALFVKACGGNTHPDGESCVTLARIGDGAWALGDSKRPDAKPLRFTTEELGAAGIDPARFGLGA
>NZ_CP016824.1|WP_067415161.1|4601135_4601390_+|hypothetical-protein
MAVAFIGIDPDTDRDHCPTVWADAEAQEVLLQGWKPSAGTQAQCEASSPANGPVPDGEAIVRIPARMIPMIREACDAVERAQLR
>NZ_CP016824.1|WP_010642895.1|4601361_4601877_+|hypothetical-protein
MPSSVLSFAELLGRCERSAVHLELRDSYAPTDRFEAWKRGERIDWQDRASWWHPYDQLIADTVARGVAIRRARVVSEPVSDYIRWEHYVTRANVTAGEEVRWLPRRRATSIALPGNDFWLFDDTLLRVHHFSGDGVVVEDEITSASEVVKLCSAAFEAVWERAVPHHLYEI
>NZ_CP016824.1|WP_067415164.1|4601891_4602740_+|helix-turn-helix-domain-containing-protein
MHSAPSSRVQKAREELAGRLREIRKDAGISGRELAARCGWSESKSSRIENAKTPPSDADVTAWCRACAADEQAPDLIAANRLSADAHVQWRRLQRSGLRRLQETTGDLYRETGTFRIYVSDVIPGFLQTPGYAAALLSSIADFRGTPDDVSDAVAARMRRNEVLSNGARRFSFVMEESVLRYRLCGAETMAAQLGHLLGVMDLQNVAVGFIPFSARRAVWPMPTFTIFDDTRVHADTLDAAATLTQPGQVELYARAFERLAQGAVRGAAARSLVADAVASLA
>NZ_CP016824.1|WP_030769811.1|4602871_4604512_+|catalase
MTEPADKDRPYLTNRQGHPVYDNQNQRTVGARGPATLENYQFLEKISHFDRERIPERVVHARGVTTFGFFEAYGKWGDEPISRYTRAKLFQEAGKRTDVAVRFSTVIGGRDSSEAARDPRGFAVKFYTEDGNWDLVGNNLGVFFIRDAIKFPDVIHSLKPDPVSHEQKPARIFDFMSQTPEAMHMLVNLFSPRGIPADYRHMQGFGVNTYKWVDAEGGTVLVKYHWVPKQGVASMTEEDAANVQADDLGHATKDLYEAIGRGDYPEWELRVQMMSDDDHPELDFDPLDDTKTWPEQDFPPRPVGRMVLDRVPGNYFAENEQAAFGTGVLVDGLDFSDDKMLVGRTFSYSDTQRYRVGPNYLQLPVNQPKAPVATNQRDGQMAYENGPDGENPEVNYEPSIMGGLREAEYPTRDEEGPVLQGRLTRARIPRTNDYLQAGQRFQLMEEWEQDDLVKNFTDLFAQCTRPVQERMIWHCLMADNELGLRVGEGIGIAPSDVAHMAPLPGQTLTEEDRVRLGRLGDNPPRDVTGLTMTHCVPDKHHVVTRR
>NZ_CP016824.1|WP_030769808.1|4604594_4605347_-|tellurium-resistance-protein-TerA
MGAGLSSDGRERKTIRLRPGGAESPARRTGAPGAEQQPPPAADAAREAAERRRRAALAKEVRLTRAEPAARLGGGGLLQVNLNWSARAEADVDLCALAEFTDGTLQVVQALGDAFGRLDAWPYIALDHDDRSGASADGETLRVNLDHHHLFRRLLFFTYLYEGSVSFRELGASVTVSGTAGTFRILLDDAPATAAGCAVALTESDGTGLTVRREVHWFDGHPELGFHELVDQAYGFGLSWTRMDKPPRLG

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP016824_27

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_27

4626469-4626554

Orphan

Consensus_repeat	Method
TGGCCTCAATCGCCGGCCGGGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_27

>merge|NZ_CP016824|27|4626469-4626554|CRISPRCasFinder
TGGCCTCAATCGCCGGCCGGGCTGTCGTGGGGCTGAGACGGCGCCTCAGCCGCCGGTCACCGATGGCCTCAATCGCCGGCCGGGCT

>NZ_CP016824|27|23|4626469-4626554|CRISPRCasFinder
TGGCCTCAATCGCCGGCCGGGCT	GTCGTGGGGCTGAGACGGCGCCTCAGCCGCCGGTCACCGA
TGGCCTCAATCGCCGGCCGGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_003950432.1\|4631555_4631819_+\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP016824.1\|WP_037638091.1\|4623816_4625226_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|128941
NZ_CP016824.1\|WP_067415182.1\|4626794_4627901_+\|3-methyladenine-DNA-glycosylase	unknown	unknown	gnl\|CDD\|223200
NZ_CP016824.1\|WP_030769792.1\|4613649_4614834_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|224235
NZ_CP016824.1\|WP_008415646.1\|4639324_4640941_+\|lactate-transporter-LctP-family-protein	unknown	unknown	gnl\|CDD\|224535
NZ_CP016824.1\|WP_008417606.1\|4615037_4615592_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|224523
NZ_CP016824.1\|WP_067415190.1\|4636257_4637799_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377520
NZ_CP016824.1\|WP_078850929.1\|4619393_4621115_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP016824.1\|WP_067415175.1\|4621439_4622747_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP016824.1\|WP_067415172.1\|4617389_4619312_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP016824.1\|WP_067415170.1\|4611995_4613528_-\|deoxyribodipyrimidine-photolyase	unknown	unknown	gnl\|CDD\|225588
NZ_CP016824.1\|WP_049978955.1\|4622906_4623659_-\|TIGR03089-family-protein	unknown	unknown	gnl\|CDD\|274426
NZ_CP016824.1\|WP_030769790.1\|4615635_4617024_-\|LCP-family-protein	unknown	unknown	gnl\|CDD\|367673
NZ_CP016824.1\|WP_003950429.1\|4629230_4630187_-\|2-phospho-L-lactate-transferase	unknown	unknown	gnl\|CDD\|237443
NZ_CP016824.1\|WP_003950436.1\|4638689_4639085_+\|DUF3499-domain-containing-protein	unknown	unknown	gnl\|CDD\|378788
NZ_CP016824.1\|WP_067415178.1\|4625345_4626437_+\|NDP-sugar-synthase	unknown	unknown	gnl\|CDD\|224129
NZ_CP016824.1\|WP_031178231.1\|4627929_4629234_-\|coenzyme-F420-0:L-glutamate-ligase	unknown	unknown	gnl\|CDD\|183957
NZ_CP016824.1\|WP_010642870.1\|4637865_4638249_-\|metallopeptidase-family-protein	unknown	unknown	gnl\|CDD\|240574
NZ_CP016824.1\|WP_067415185.1\|4630191_4630704_-\|cysteine-dioxygenase	unknown	unknown	gnl\|CDD\|380416
NZ_CP016824.1\|WP_067415187.1\|4632502_4636261_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|224137

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_003950432.1\|4631555_4631819_+\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	5.22363e-28
NZ_CP016824.1\|WP_037638091.1\|4623816_4625226_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|128941	smart00701, PGRP, Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine.	3.34922e-48
NZ_CP016824.1\|WP_067415182.1\|4626794_4627901_+\|3-methyladenine-DNA-glycosylase	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	3.9985e-20
NZ_CP016824.1\|WP_030769792.1\|4613649_4614834_-\|LCP-family-protein	gnl\|CDD\|224235	COG1316, LytR, Transcriptional regulator [Transcription].	8.01697e-57
NZ_CP016824.1\|WP_008415646.1\|4639324_4640941_+\|lactate-transporter-LctP-family-protein	gnl\|CDD\|224535	COG1620, LldP, L-lactate permease [Energy production and conversion].	6.11682e-139
NZ_CP016824.1\|WP_008417606.1\|4615037_4615592_+\|acyl-CoA-thioesterase	gnl\|CDD\|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	1.03667e-48
NZ_CP016824.1\|WP_067415190.1\|4636257_4637799_+\|hypothetical-protein	gnl\|CDD\|377520	pfam05506, DUF756, Domain of unknown function (DUF756). This domain is found, normally as a tandem repeat, at the C-terminus of bacterial phospholipase C proteins.	0.00407542
NZ_CP016824.1\|WP_078850929.1\|4619393_4621115_-\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	1.36745e-54
NZ_CP016824.1\|WP_067415175.1\|4621439_4622747_-\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	7.4743e-62
NZ_CP016824.1\|WP_067415172.1\|4617389_4619312_-\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	2.53142e-42
NZ_CP016824.1\|WP_067415170.1\|4611995_4613528_-\|deoxyribodipyrimidine-photolyase	gnl\|CDD\|225588	COG3046, COG3046, Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only].	1.69786e-154
NZ_CP016824.1\|WP_049978955.1\|4622906_4623659_-\|TIGR03089-family-protein	gnl\|CDD\|274426	TIGR03089, conserved_hypothetical_protein, TIGR03089 family protein. This protein family is found, so far, only in the Actinobacteria (Streptomyces, Mycobacterium, Corynebacterium, Nocardia, Propionibacterium, etc.) and never more than one to a genome. Members show twilight-level sequence similarity to family of AMP-binding enzymes described by pfam00501.	1.7579e-75
NZ_CP016824.1\|WP_030769790.1\|4615635_4617024_-\|LCP-family-protein	gnl\|CDD\|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	2.74883e-54
NZ_CP016824.1\|WP_003950429.1\|4629230_4630187_-\|2-phospho-L-lactate-transferase	gnl\|CDD\|237443	PRK13606, PRK13606, LPPG:FO 2-phospho-L-lactate transferase; Provisional.	4.5399e-174
NZ_CP016824.1\|WP_003950436.1\|4638689_4639085_+\|DUF3499-domain-containing-protein	gnl\|CDD\|378788	pfam12005, DUF3499, Protein of unknown function (DUF3499). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 125 to 163 amino acids in length.	8.96775e-53
NZ_CP016824.1\|WP_067415178.1\|4625345_4626437_+\|NDP-sugar-synthase	gnl\|CDD\|224129	COG1208, GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis].	9.03587e-98
NZ_CP016824.1\|WP_031178231.1\|4627929_4629234_-\|coenzyme-F420-0:L-glutamate-ligase	gnl\|CDD\|183957	PRK13294, PRK13294, F420-0--gamma-glutamyl ligase; Provisional.	0
NZ_CP016824.1\|WP_010642870.1\|4637865_4638249_-\|metallopeptidase-family-protein	gnl\|CDD\|240574	cd12954, MMP_TTHA0227_like_1, Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria. The subfamily includes some uncharacterized bacterial proteins which show high sequence similarity with Thermus thermophilus hypothetical protein TTHA0227. However, they do not contain the conserved HExxH (x could be any amino acid) motif. They may not have any zinc metallo-peptidase activity.	4.12898e-26
NZ_CP016824.1\|WP_067415185.1\|4630191_4630704_-\|cysteine-dioxygenase	gnl\|CDD\|380416	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain. This family contains cysteine dioxygenase (CDO; EC 1.13.11.20), which catalyzes the conversion of cysteine to cysteine sulfinic acid, the first step in the biosynthesis of essential oxidized cysteine metabolites such as sulfate, hypotaurine, and taurine. CDO also plays an important role in the regulation of intracellular cysteine levels in mammals; CDO expression is altered in cancer cells, and abnormal or deficient CDO activity has been linked to Parkinson's disease, Alzheimer's disease, and rheumatoid arthritis. CDO is an iron-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate cysteine sulfinic acid. The CDO active site contains an amino acid-derived cofactor. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.40265e-23
NZ_CP016824.1\|WP_067415187.1\|4632502_4636261_+\|glycosyltransferase	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	3.21067e-33

>NZ_CP016824.1|WP_067415178.1|4625345_4626437_+|NDP-sugar-synthase
MTQAPEAILLVGGKGTRLRPLTVRTPKPMVPAAGVPFLTHQLARARAAGVEHVVMATSYLAEVFEPYFGDGSDLGLHLEYVTEEEPLGTGGAIRNVAPRLHSGPDDPVLIFNGDILTGLDIPALVATHQESGADVSLHLSRVEDPRAFGLVPTDEAGRVLAFLEKPQTPEEIVTDQINAGAYVFRRSVIDTIPTGRPVSVERETFPGLLESGPHLQGMVDSTYWLDLGTPQAFVRGSADLVLGRAPSPAVPGRRGESLVLDGAHVAPDAKLSEGTVVGVGAHVGAGARITGSTLLDGAYVAEGAVVTDSLIGAGARVGARTHVTGAVIGDGADAGADNELRDGLRLWCDAVLPDGGVRFSPDR
>NZ_CP016824.1|WP_037638091.1|4623816_4625226_+|N-acetylmuramoyl-L-alanine-amidase
MTCAAALALPAALPSGALAATAAHPRAGAADTSTGAPAADALPAAPPGAHTLPAADDTPGHTRSLPLPDAPAGRSSEPGEGPDERALSPREVEPFSLLGVVWDDPDAHLEGRVQVRTRSTVTGAWSGWQELESHHDDHGADRSTPEGAAGRGATAPLWVGRSDAVELRVTARDDHRHQGERTTDRLPEGLRLDLVDPGEAPALEEEPAPRPTRAGAPAATPAGLPEAAGEPAVLPELTREETLAELEAARAVEEPEAGAAGPQQRAQPYVGPRPKIVTRKGWGADEKLREKNFAYTGKVKAAFVHHSATGNNYTCAQAPSVIRGIYRYHTQSSGWRDLGYNFMVDKCGTVYEGRAGGVDKAVLGAHTLGFNSNSTGIAVLGSYSSVKPPKAAVDAVAKLTAWKLGLSGANPKGKVTLTSGGSNLYAKGKKVSLHVISGHRDGYSTECPGTRLYGQLGTARSASARLQGR
>NZ_CP016824.1|WP_049978955.1|4622906_4623659_-|TIGR03089-family-protein
MNAIDRTPADLLRSALAADPARPLVTFYDDATGERVELSVATFANWVAKTANLLQGDLSAEPGDRLALLLPAHWQSAVWLLACHSTGVVAEVGGDPAAADLVVSGPDTLDAARACSGERIALALRPLGGRFPHAPEGFADYAVEVPGQGDRFAPFAPVEPDEPALAVAGRELTGAELVEEARAEAARLGLGPSDRVLSGLGWETWEGLAAGLYAPLAAGGSVVLCRNTGGLSEEGLARRVADERVDLTLL
>NZ_CP016824.1|WP_067415175.1|4621439_4622747_-|LCP-family-protein
MTDRAGRPDGQGDEGNDEGNQETAGSGAREQGAHWGPRPARQGPARRPFLRRRWVWWTAAGTTVALVGAGVGAWALYDRLQGNITRDDAVIAELERHEKERPLPSKQGALNILLVGSDTRAGQGNGQYGVARGQRSDTVIMLHLAADRRSATAMSIPRDLMVEIPSCRRADGESTPARTAQFNDAYSYGGTACTIRTVERLTRIRVDHHMVVDFQGFKRMVDAVDGVRICLKQPMDDKDAHVRLPAGEHTLNGEQSLGFVRARKSLGNGSDTDRMERQQQFLGALVAKVQSNGVLLNPGKLYPLLDAATSSLTTDPSLSSLIDLYDLVRSMRNIPTKEVRFLTVPREAYAGDPNRDQLVEPAASELFTLLREDEPVRIAPRPSDSASPAPSASPTGTGPAAPSASSAPPGTPGVRSTPVPDPTFSGNSAARSACE
>NZ_CP016824.1|WP_078850929.1|4619393_4621115_-|LCP-family-protein
MRLSPSDGRPPGNGRRGAVPRSRRAPDREHPQPGQERPRRPAPEHDDPEPGSRPSRETVPGQRRRRGAEPEPPPGRAAARRAGGRKGRGQKQKKGKKKVLLWTGGVLAFVMVALAASAYAYLEHLKDNINSVADDGAGTGGFSKDRAINVLLIGTDKRSGEGNEGYGDKDSPGHADTTFILHVSKDRSNATALSIPRDLITDIPDCPTQQEDGTETVIPGRQGTKFNESLGQSERTPSCTMRTVTELTGIKMDHFMVADFNAVKTLTTAVGGVEVCLAKDIDDPDSHLKLSKGTHTIEGEEALAFVRTRHSVGFGGDLSRIEIQQQFLSSLMRKLSSNDTLTSPTKMFSLAEAGTKALTVDSTLADISKLRDLGMELGKLDPKNLTFATIPVKDNPAEPTPVTVVLDDPKAQSVFQMVREDVSFTAVKKKEKKEKAAVAARLKGERADPTEVRVDVYNGGAATGSAQTTLTWLQNTQGVLKSTQLGNAPEELAKTTVEYGEEEAPQARALADMMGLPASALKPGESVSNSQGLPAVKLTLGRDFKGAGIPLVAPKEAPKGVNKVSADKTVCAK
>NZ_CP016824.1|WP_067415172.1|4617389_4619312_-|LCP-family-protein
MGSARSEGGPERDQDPAGALGWDEGLYEGRDAAVETGRAKVPGQRGAGDAGGADGEGETEPEDPDEQPDRDSGTPVGVPEQPGPPAGESGPGRRRPEAGGERDAPEDAPEEAPDEAPGDASGEAPEEADAEAAAKPRKPKRRKRRILAWTAAGLALTLVAAGTAGWFYYQHLNDNLDRKPLHIGKSRAPEPTPNAAGQTPLNILLIGSDARDSEENQRLGGARETFGGPALADVQMLLHLSADRSHMSVISMPRDTLLKIPECTDPESGKVYPATVGTRMTNQTLMRGGPGCTVATWEELTGIRIDHFMMVDFAGVVSMADAIGGVPVCVDANLHSRTSDGKGSGLKLKKGTTEIKGEDALAWLRTRYGFGDGSDIARAKAQHMYMNSLVRKLRENTGLSSPNKLRNLAEEATEALTVDEELASVAELYALAEELKKVAPNRTTMATMPWIWSPSDHNRVEPKPDDAEQLFRLVREDIALDGRDGDGPSPSPSEDETSEDPADDPADIAVLVRNGTGSPVAAPVSGRASDLVKLLTEAGFTRATADQNQVENREETAILYPSAELEGDAQSVAEALGMPLGTVRKSAEVSGVTLEIGADWTEGDTFPKPKKGDNEPPDSAEALNGSDDTACMEVDPAFTW
>NZ_CP016824.1|WP_030769790.1|4615635_4617024_-|LCP-family-protein
MRAVTALSVAVLASSGVGHAVMSGLDSGIERVDPFKDMKNRPEAGRGLNILLAGTDGRDTITEEQRQAYRLGGKPCHCTDTLMLLHLSADHSRVSVVSLPRDSYAMMPPHTDRTSGEEHRPHPVKLNAAYAEGGPELTVRTVEKMTEVKIDHYVEVDFTSFMETVDAVGGVEICTVRRLKDSYTGLDLAPGPHRLDGGQALQYVRSRHLDGTGDLSRMQRQQRFLAALTAEVTGSGVLLNPVRFREVAQSVLGSLRADSGFTTERMLDLGKAMRGFTPASAEFTSVPVQEEAREVPAVGNTLVWKAKEAKRIFGALREDRPLADHDSARSKATVVDVPPEQIRVQVENGTPRQGLGAQADRALRATGFGTSGQAVDAPDRATARTTVLYDPRWDRSARTVAAAFPGAELKAAPGQGGTLRVVLGADFTEVHPVRAEDPPEGATGALRGDEVTCPRPEPAGKA
>NZ_CP016824.1|WP_008417606.1|4615037_4615592_+|acyl-CoA-thioesterase
MTDPARVPESEIPGKPTSASRTTLSHIMTHNDTNLLGTVHGGVIMKLVDDAAGAVAGRHSEGPAVTASMDEMAFLMPVRVGDLLHVRAQVNWTGRSSMEVGVRVVAERWNDSTPAQQVGTAYLVFTAVDADGKPRQVPPVIPETERDKRRYQEAQIRRTHRLARRRAILDLREQRAAEGLDADD
>NZ_CP016824.1|WP_030769792.1|4613649_4614834_-|LCP-family-protein
MPHVRRRQAPPPAAPPRTTVPPQPQYGRPGGRDDYDDGYNTGQVYGGGGGGRGGGGYQDGPGGPGGRRPAPNWGRRVKVGLITFLVAALVVSVGTYMWASSKLRGEVDLAKVIERPEEGEGTNYLIVGSDSRDGMTDDDKKRLHTGSAEGKRTDSMMILHVGSNGNTMVSLPRDSEVEIPSFKGSESGKLFPAQGRRVKLNAAYAEDGPELLVRTVEYNTGLRIDHYAEIGFGGFANIVDALGGVEMDIPKAFKDKKSGADFQAGKQTLDGEQALAFVRTRYAFAGSDLDRTKNQQKFLATLANQAATPSTVLNPFRLYPTLGAGLDTLIVDKDMGLFDLAGMFWAMKGLTGGEGTSMNMPISGSNGGNLVWDKAKKDQLMQQLRNDEKVTVTE
>NZ_CP016824.1|WP_067415170.1|4611995_4613528_-|deoxyribodipyrimidine-photolyase
MGQRSGGKGTGAVHWLFGDQLGPHFLTPGEDGPHRDTPLVMIESRAVFRRRRFHRAKAHLVLSAMRHRAAELGDRVTYVKAGTYREGLRKAAGKRPVTVHHPTSRAALALVDALPQVTVLPARGFLVGHQEFADWAEGRGGRALRQEDFYRRTRAAHDLLMEGDRPASGRWNLDHDNREPPPRDAGALDVPAPYRPREDAIDEEVRHDLDRWERSGEVTFVGRDGPRHFPATRREALNALRRFVSDRLATFGPYEDAMLTADPVMSHSLLSSSLNLGLLDPAECVERAEAAWRAGEAPLNSVEGFVRQIAGWREYIWHLYWHFGEEYRTTNALGHHAPLPDWWSDLDADAVTAHCLSTVLAQLRDTGWTHHIPRLMVLGNYALQRGWDPAALTDWFHRCFVDGYDWVMLPNVLGMSQYADGGRMTTKPYASGGAYLNRMSDYCSPCAYRPDHRTGDRACPYTAGYWSFVHRHHERLVHNPRTAQAARGMERLKDLDEVLGQERERGDAAP
>NZ_CP016824.1|WP_067415182.1|4626794_4627901_+|3-methyladenine-DNA-glycosylase
MATPAPSSLAPRASTLWRMAGRFPPRPRAPYGTSEGTPCPDTRPDPTGARTFRAATQAAAAARPEAPARSRAWTPPYQADLGLILGVLRRGPGDPAFRLTQDRAVWRASRTPEGPATLRVTLRAGRAEATAWGPGADWFLDRLPELLGAADSPEAFTPRHRLVADSARRATGLRLTRTGLVLESLIPSVLEQKVTADEAYRAWRRLLTRHGEPAPGPAPERMAVMPDPRAWSLIPSWEWHRAGVDDKRAATILRAVRLHSRLERAAGLPPEKAAALLEAVPGIGPWTSAEVVQRTHGAPDAVTTGDLHLPGIIGYALTGDRTTDDAAMLELLAPYAGQRHRAARLILLAGRVPPRRTPKMPYSDISRL
>NZ_CP016824.1|WP_031178231.1|4627929_4629234_-|coenzyme-F420-0:L-glutamate-ligase
MSAAPAFQVRAVPGLPEVGEGDDLAKLIAAAAPTLADGDIVLVTSKIVSKAEGRVLAADSREAAIDAETVRVVARRGALRIVENRQGLVMAAAGVDASNTPAGTVLLLPEDPDASARALRAGLADALGVDVGVVVTDTFGRPWRNGLTDVAIGSAGVRVLDDLRGGTDAHGNPLHATVIALADELAAAGDLVKGKSEGLPVAVVSGLSALVGGEEGAGARELVRGAADDMFRLGTSEAVREAVTLRRTVRSFTDEPVDPGAVRRAVAAAVTAPAPHHTTPWRFVLLESAAARTRLLDAMRDAWIADLRRDGKSEESIAKRVRRGDVLRNAPYLVVPCLVMDGSHAYPDERRSAAEREMFVVATGAGVQNFLVALAGEQLGSAWVSSTMFCRDVVREVLDLPDTWDPMGAVAVGRAATPPADRPGRDPETFLTVR
>NZ_CP016824.1|WP_003950429.1|4629230_4630187_-|2-phospho-L-lactate-transferase
MRIVVLAGGIGGARFLRGLKAAAPDADITVIGNTGDDIHLFGLKVCPDLDTVMYTLGGGINEEQGWGRTDETFQVKDELKAYGVGPDWFGLGDRDFATHIVRTQMLGAGYPLSAVTEALCERWQPGVRLLPMTDDRVETHVAVDLDGERRAVHFQEYWVRLRASVDALAVVPVGAEQSKPAPGVLEALAEADVVLFPPSNPVVSIGTILAVPGIREAIAEAGVPVVGLSPIVGGAPVRGMADKMLSAIGVETAAAAVAEHYGSGLLDGWLVDSADTGAVAEVEAAGIRCRAVPLMMTDLDATAAMAREALALAEEVRA
>NZ_CP016824.1|WP_067415185.1|4630191_4630704_-|cysteine-dioxygenase
MNQDSDPQIAGDLLEVQHLLRPAPEHPSTVAGFVRLARTVAADRARWAPLVAYDPTSRWYHRLETGPGYEVWLLSWLPGQGSGAHDHGRSAGVMTVLDGALTEHTPGGRQVLRPGGHRVVAPGHAHEVVNDALEPAVSLHVYFPGLTTMPVRTLERSATTPAEEPARLTH
>NZ_CP016824.1|WP_003950432.1|4631555_4631819_+|WhiB-family-transcriptional-regulator
MTELFEQLLVEEADEELGWQERALCAQTDPESFFPEKGGSTREAKKVCLACEVRSECLEYALANDERFGIWGGLSERERRRLKKAAV
>NZ_CP016824.1|WP_067415187.1|4632502_4636261_+|glycosyltransferase
MSVHSHSAAYPAASAGSMSDPAATMTATPTSLPGLDPTSAPAYARHVVTAVLVTHDGARWLPDALAGLLAQERPVQNAVAADTGSADDSARLVADAFGDDRVLHLARRTGFGTAVDEAVRAAGVLTPDDLPYLKRPGGWDPVARQWHDENYDLPELPYGEPEQWLWLLHDDCAPAPDALAGLLAAVEAEREAGGEVAIVGPKLRGWYDRRQLLEVGVTIAHSGRRWTGLDRREQDQGQHDHVRPVLSVSTAGMLIRRDVYEELGGFDRALPLMRDDVDLCWRAQAAGHRVLIAPDAVLRHAEAASRERRTVDCAGRGTTSPHRVDKAGAVHTLLVNSRGAALPWVLLRLIVGTVARTLAYLVGKVPGQAVDEISGLLGTLLRPGRILNARRRRGKGTVEPAELRPLFPPPGATVRATVEQVAGNLTRGSDADAPGAGRHGGAVESGPGGDDADFLEVEQFARLKRLARRPGPVLFAVLLLASLVACRALLGGGALAGGALLPVPDQLGDLWGRYADGWHAVGTGTTEPAPPYLALLATLAALLFGSTHTAVTVVLVASVPLAGFAAYLASGSLVPSRLLRAWGSVVYAFLPAVTGALAGGHLGTAVLAVLLPVMARAGLSAAGLLGHPGTWRATWAYTLLLTLATAFTPMVWPLALVLGIGVLVVRRSALGTYAPRFVAQFATPLLVLAPWSLTLLPFGFFQTAGLDTATGGAGPLDLLGASPGGPGTLSAVLFLGVVAAALGALLREERRRAILTAWAVALTALLFAVLANASAWAGPATLVQGAALLGAALVGADGARHRVAEQSFGWRQPLAALIALACALGPAAAALTWMAAGADGPLERRDPVQVPAFVAEESRTQDQARTLVLAGDSATEVSYALVRGSGGRLGDAELAAAAGTDDRLSTVVARLVAGSGADQADQLGGFAVRYVLVRDGSPREMSRVLDSTPGLTRLSQQDGSALWRVDRQVSRAAVVAKDGSGEPLPVAAGPVELHTDLPAGPAGRVLRLADTADPGWTATLDGEPLERVTVDDWAQGFTLPEGGGRLDVTFEDPFTHTVWIWTQGFLGLVLVVLALPGRRRTVDDDMPDEPAPVPAQPVEGEGRRARRLRAQAEAEADDAAPDAAPEADIPEQREPPGGEPDPAWTAAPEPYEPVDPQQGGYDPYGYQNQGYDQSPQGYPPQPGYDPNAYDPYQQQPQDPYQQGGWQQGQQGYPGYEQQPQQGYGPGQAAPEYGQYEQPPHGHGRERPDGSQQ
>NZ_CP016824.1|WP_067415190.1|4636257_4637799_+|hypothetical-protein
MKRTTLSLIAAGAALAAVTSVAAVAAPEEGPAATGKAAQQPVERTSLLCPAPSSSELAETTYTAYTPKTEVSSDSGTAALVPAARSLAGKDDKKDDEKDGKGDKSDKKGEEEKPFLAVKKQGAPVTAEENGSGAPALIGLAEGSLAPGWSAQQTTHFTAGAGRGLHGAACSAPDTDFWFPGASTAEDRSDYLHLTNPDDAAAVVDIELYGKDGALDSEVGEGIQVPPRSSVPVLLSTLTGKPQTNLTVHVTARSGRVAAAVQALDQKVGGDWLTPSAEPSASVVLPGIPKDATAVRLVAFAPGSADADLKVSLAGPNGSLSPAGNETLHLKSGMTTAVDLADVTRGEPGSLVLTPTGDSGETPVVAAVRVIRGKGADQESAFIPAARPVGDRATVTGNGAKGTYLSLTAPGKAAKVRVTASAGTGGGTAATKTYSVGAGRTLAADVPLPDSLKGTYALTVETVSGGPVHASRTLTLSGAAADGISMFTVQNLTDDRGTVTVPAARPEMGVLLD
>NZ_CP016824.1|WP_010642870.1|4637865_4638249_-|metallopeptidase-family-protein
MRGPVAPPQVPLSASRAQVFDDFVRDAVERLERHVPQIADIDFVVQEVPRPQGPGDDWQDEAVPLGAALEARKGRPAQVVVYRRPVEIRAKGRDERALLVHEVVVEQVADVLGLTPEAVDPRYGEGE
>NZ_CP016824.1|WP_003950436.1|4638689_4639085_+|DUF3499-domain-containing-protein
MSPVRRCSRTACGRPAVATLTYVYADSTAVLGPLATYAEPHCYDLCAEHSERLTAPRGWEVVRLADSAGPARPRGDDLEALADAVREAARPQDRPAAPGHRTPDPAPRPAPDPQLPATRRAHLRVLRSPDS
>NZ_CP016824.1|WP_008415646.1|4639324_4640941_+|lactate-transporter-LctP-family-protein
MFVQPLEPVADSLPLSALVAALPLVTVLVLLGAVRMKAHLAGALGLAVAALVAWLVYGMPLGQTLSSAAQGALFGLFPIMWIVVNALWVYRMTVRTQHFDILRRSFGRLSDDPRIQALVIAFCFGALLEALAGFGAPVAISAVMLVALGFDPVRAAVVALVANTAPVAFGAMGTPVVTLAQVTGLPLDSVASVVGRQTPLLALVVPLVLIWLVDGRRGLRETWLPALVCGVAFAAAQFLAANYFSAQLADIAAALAGAAALMLVPSARRPADEAVRASVLKGVRSDDLDHDDPRPEIYRAYAPYALIVAVFSLAQIPPVKELLAKATQSFDWPFLDVADADGQPVGANIFTLPLVATGGTLVLVAGLLTAVVLGVRAKDALREWGATVHELRFAILTVVSVLALAYVMNLSGQAATIGYTVAAAGAGLAFLSPVLGWFGVAVTGSDTSANALFGALQVTAARESGLSAELLAAANSSGGVLGKMISPQNLTIACAAVGLAGKEGDLLRKVLPWSLGLLLVMCLIVVGQSTAVLGWMLP

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Crispr_ID: NZ_CP016824_28

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_28

4644550-4644637

Orphan

Consensus_repeat	Method
CAGCCCGGCCGGCGTTTGAGGCCATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_28

>merge|NZ_CP016824|28|4644550-4644637|CRISPRCasFinder
CAGCCCGGCCGGCGTTTGAGGCCATCGGTAGGCGGCACTGTCGATCGGACCGAGCCCAAAATCAGCCCGGCCGGCGCTTGAGGCCATC

>NZ_CP016824|28|24|4644550-4644637|CRISPRCasFinder
CAGCCCGGCCGGCGTTTGAGGCCATC	GGTAGGCGGCACTGTCGATCGGACCGAGCCCAAAAT
CAGCCCGGCCGGCGCTTGAGGCCATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067415190.1\|4636257_4637799_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377520
NZ_CP016824.1\|WP_003950432.1\|4631555_4631819_+\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP016824.1\|WP_067415206.1\|4647772_4648744_+\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP016824.1\|WP_003950444.1\|4648980_4650435_+\|adenosylhomocysteinase	unknown	unknown	gnl\|CDD\|377487
NZ_CP016824.1\|WP_008415646.1\|4639324_4640941_+\|lactate-transporter-LctP-family-protein	unknown	unknown	gnl\|CDD\|224535
NZ_CP016824.1\|WP_067415201.1\|4645210_4646368_+\|mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|378434
NZ_CP016824.1\|WP_008415631.1\|4652215_4653220_+\|stage-II-sporulation-protein-M	unknown	unknown	gnl\|CDD\|376676
NZ_CP016824.1\|WP_067415213.1\|4659066_4660374_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CP016824.1\|WP_010642870.1\|4637865_4638249_-\|metallopeptidase-family-protein	unknown	unknown	gnl\|CDD\|240574
NZ_CP016824.1\|WP_067415204.1\|4646488_4647652_+\|mannose-6-phosphate-isomerase,-class-I	unknown	unknown	gnl\|CDD\|185085
NZ_CP016824.1\|WP_067415193.1\|4640882_4641515_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP016824.1\|WP_067415211.1\|4651214_4652144_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|224628
NZ_CP016824.1\|WP_003950436.1\|4638689_4639085_+\|DUF3499-domain-containing-protein	unknown	unknown	gnl\|CDD\|378788
NZ_CP016824.1\|WP_008409130.1\|4660386_4661367_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_CP016824.1\|WP_067415198.1\|4643652_4644327_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378924
NZ_CP016824.1\|WP_067415209.1\|4650576_4651200_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067415196.1\|4641640_4643023_+\|phosphomannomutase/phosphoglucomutase	unknown	unknown	gnl\|CDD\|236557
NZ_CP016824.1\|WP_067415185.1\|4630191_4630704_-\|cysteine-dioxygenase	unknown	unknown	gnl\|CDD\|380416
NZ_CP016824.1\|WP_067415187.1\|4632502_4636261_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|224137
NZ_CP016824.1\|WP_008415641.1\|4644773_4644956_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225391

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067415190.1\|4636257_4637799_+\|hypothetical-protein	gnl\|CDD\|377520	pfam05506, DUF756, Domain of unknown function (DUF756). This domain is found, normally as a tandem repeat, at the C-terminus of bacterial phospholipase C proteins.	0.00407542
NZ_CP016824.1\|WP_003950432.1\|4631555_4631819_+\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	5.22363e-28
NZ_CP016824.1\|WP_067415206.1\|4647772_4648744_+\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	2.35609e-40
NZ_CP016824.1\|WP_003950444.1\|4648980_4650435_+\|adenosylhomocysteinase	gnl\|CDD\|377487	pfam05221, AdoHcyase, S-adenosyl-L-homocysteine hydrolase.	0
NZ_CP016824.1\|WP_008415646.1\|4639324_4640941_+\|lactate-transporter-LctP-family-protein	gnl\|CDD\|224535	COG1620, LldP, L-lactate permease [Energy production and conversion].	6.11682e-139
NZ_CP016824.1\|WP_067415201.1\|4645210_4646368_+\|mannose-6-phosphate-isomerase	gnl\|CDD\|378434	pfam10432, bact-PGI_C, Bacterial phospho-glucose isomerase C-terminal SIS domain. This is the C-terminal SIS domain of a bacterial phospho-glucose isomerase EC:5.3.1.9 protein which is similar to eukaryote homologs to the extent that the sequence includes the cluster of threonines and serines that forms the sugar phosphate-binding site in conventional PGI. This domain contributes a good proportion of the active catalytic site residues. This PGI uses the same catalytic mechanisms for both glucose ring-opening and isomerisation for the interconversion of glucose 6-phosphate to fructose 6-phosphate. It is associated with family SIS, pfam01380.	5.33398e-16
NZ_CP016824.1\|WP_008415631.1\|4652215_4653220_+\|stage-II-sporulation-protein-M	gnl\|CDD\|376676	pfam01944, SpoIIM, Stage II sporulation protein M. SpoIIM is on e of four stage II sporulation proteins that is necessary for the forespore inside the mother-cell to be properly internalized through the breakdown of peptidoglycans trapped between the membranes of the septum separating the forespore and the mother-cell. The four proteins working in sequence are SpoIIB, pfam05036, SpoIIM, SpoIIP, pfam07454, and finally SpoIID, pfam08486. D, M and P are in a complex with each other and the complex assembles in a hierarchical manner such that M, which serves as a membrane anchor, recruits P to the septum and P, in turn, recruits D to the septum.	7.07653e-42
NZ_CP016824.1\|WP_067415213.1\|4659066_4660374_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	5.60455e-47
NZ_CP016824.1\|WP_010642870.1\|4637865_4638249_-\|metallopeptidase-family-protein	gnl\|CDD\|240574	cd12954, MMP_TTHA0227_like_1, Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria. The subfamily includes some uncharacterized bacterial proteins which show high sequence similarity with Thermus thermophilus hypothetical protein TTHA0227. However, they do not contain the conserved HExxH (x could be any amino acid) motif. They may not have any zinc metallo-peptidase activity.	4.12898e-26
NZ_CP016824.1\|WP_067415204.1\|4646488_4647652_+\|mannose-6-phosphate-isomerase,-class-I	gnl\|CDD\|185085	PRK15131, PRK15131, mannose-6-phosphate isomerase; Provisional.	9.53405e-109
NZ_CP016824.1\|WP_067415193.1\|4640882_4641515_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.83608e-13
NZ_CP016824.1\|WP_067415211.1\|4651214_4652144_-\|RDD-family-protein	gnl\|CDD\|224628	COG1714, COG1714, Predicted membrane protein/domain [Function unknown].	7.211e-17
NZ_CP016824.1\|WP_003950436.1\|4638689_4639085_+\|DUF3499-domain-containing-protein	gnl\|CDD\|378788	pfam12005, DUF3499, Protein of unknown function (DUF3499). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 125 to 163 amino acids in length.	8.96775e-53
NZ_CP016824.1\|WP_008409130.1\|4660386_4661367_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	7.4797e-101
NZ_CP016824.1\|WP_067415198.1\|4643652_4644327_-\|alpha/beta-hydrolase	gnl\|CDD\|378924	pfam12697, Abhydrolase_6, Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.	3.75609e-09
NZ_CP016824.1\|WP_067415196.1\|4641640_4643023_+\|phosphomannomutase/phosphoglucomutase	gnl\|CDD\|236557	PRK09542, manB, phosphomannomutase/phosphoglucomutase; Reviewed.	0
NZ_CP016824.1\|WP_067415185.1\|4630191_4630704_-\|cysteine-dioxygenase	gnl\|CDD\|380416	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain. This family contains cysteine dioxygenase (CDO; EC 1.13.11.20), which catalyzes the conversion of cysteine to cysteine sulfinic acid, the first step in the biosynthesis of essential oxidized cysteine metabolites such as sulfate, hypotaurine, and taurine. CDO also plays an important role in the regulation of intracellular cysteine levels in mammals; CDO expression is altered in cancer cells, and abnormal or deficient CDO activity has been linked to Parkinson's disease, Alzheimer's disease, and rheumatoid arthritis. CDO is an iron-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate cysteine sulfinic acid. The CDO active site contains an amino acid-derived cofactor. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.40265e-23
NZ_CP016824.1\|WP_067415187.1\|4632502_4636261_+\|glycosyltransferase	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	3.21067e-33
NZ_CP016824.1\|WP_008415641.1\|4644773_4644956_+\|hypothetical-protein	gnl\|CDD\|225391	COG2835, COG2835, Uncharacterized conserved protein [Function unknown].	1.13232e-13

>NZ_CP016824.1|WP_067415198.1|4643652_4644327_-|alpha/beta-hydrolase
MGGVVLVHGLYHQAGHFGVVAAGLRRVGVEVVVPELHRGSLREDTRVVQEAVDGFGVAPVVVGHSYGGSVITGVRGAGHLVYLAAFVLDAGESAAGWGGGSAALREAGVAAGEEGATRLRPELAAGVLYDDCPAPLARRAVGLLREQGPGCGRGVPERQGWRTTPSTYVVCARDRAIDPGVQRRMAARCGEVREWPTGHSPFVGRPELVVGLVRGVLAGIGGRG
>NZ_CP016824.1|WP_067415196.1|4641640_4643023_+|phosphomannomutase/phosphoglucomutase
MTADLSQIVKAYDVRGVVPDQWDEHLSALFGAAFAQVTAVPAGSGAIVVGHDMRPSSPGLSHAFARGAAEQGLDVVEIGLCSTDQLYYASGALDLPGAMFTASHNPAQYNGIKLCRAGAAPVGQDTGLADIRALVESWLDDPASAPAPAAPPGTLSRRDTPADYAAYLRSLVDVSGIRPLKVVVDAGNGMGGHTVPTVLGDLPLTVVPLYFELDGTFPNHEANPLDPKNLVDLQARVRAEGADLGLAFDGDADRCFVVDERGEPVSPSAVTALVAARELARNGGHGTVIHNLITSWSVPEVVREHGGTPARTRVGHSFIKAEMAATGAIFGGEHSAHYYFRDFWNADTGMLAALHVLAALGGQPAPFSTLVAEYDRYPASGEINSTVTDQQATTARVRAAYADHPAATTDTLDGLTVTTPDWWFNLRPSNTEPLLRLNVEARDRQTLERLTTEVLELVRQ
>NZ_CP016824.1|WP_067415193.1|4640882_4641515_-|GNAT-family-N-acetyltransferase
MTWVREMAVGDAAAVSAVRVAGWRAAYAGVIPGAYLDAMSAERDAARREERFAAGRAAGLCDLVAAGADGQVAGWACCGPRGTPGDGPGAGEGELYALYVRPGLLGRGVGRALLGAVHQEAAARGWGALVLWVVEANARARRFYEAAGYRADGGAQSEEYAGVAVREVRYRRPAGPFPGGPGQPSGVRRTGSRAASTPGPPCSAPPRSGT
>NZ_CP016824.1|WP_008415646.1|4639324_4640941_+|lactate-transporter-LctP-family-protein
MFVQPLEPVADSLPLSALVAALPLVTVLVLLGAVRMKAHLAGALGLAVAALVAWLVYGMPLGQTLSSAAQGALFGLFPIMWIVVNALWVYRMTVRTQHFDILRRSFGRLSDDPRIQALVIAFCFGALLEALAGFGAPVAISAVMLVALGFDPVRAAVVALVANTAPVAFGAMGTPVVTLAQVTGLPLDSVASVVGRQTPLLALVVPLVLIWLVDGRRGLRETWLPALVCGVAFAAAQFLAANYFSAQLADIAAALAGAAALMLVPSARRPADEAVRASVLKGVRSDDLDHDDPRPEIYRAYAPYALIVAVFSLAQIPPVKELLAKATQSFDWPFLDVADADGQPVGANIFTLPLVATGGTLVLVAGLLTAVVLGVRAKDALREWGATVHELRFAILTVVSVLALAYVMNLSGQAATIGYTVAAAGAGLAFLSPVLGWFGVAVTGSDTSANALFGALQVTAARESGLSAELLAAANSSGGVLGKMISPQNLTIACAAVGLAGKEGDLLRKVLPWSLGLLLVMCLIVVGQSTAVLGWMLP
>NZ_CP016824.1|WP_003950436.1|4638689_4639085_+|DUF3499-domain-containing-protein
MSPVRRCSRTACGRPAVATLTYVYADSTAVLGPLATYAEPHCYDLCAEHSERLTAPRGWEVVRLADSAGPARPRGDDLEALADAVREAARPQDRPAAPGHRTPDPAPRPAPDPQLPATRRAHLRVLRSPDS
>NZ_CP016824.1|WP_010642870.1|4637865_4638249_-|metallopeptidase-family-protein
MRGPVAPPQVPLSASRAQVFDDFVRDAVERLERHVPQIADIDFVVQEVPRPQGPGDDWQDEAVPLGAALEARKGRPAQVVVYRRPVEIRAKGRDERALLVHEVVVEQVADVLGLTPEAVDPRYGEGE
>NZ_CP016824.1|WP_067415190.1|4636257_4637799_+|hypothetical-protein
MKRTTLSLIAAGAALAAVTSVAAVAAPEEGPAATGKAAQQPVERTSLLCPAPSSSELAETTYTAYTPKTEVSSDSGTAALVPAARSLAGKDDKKDDEKDGKGDKSDKKGEEEKPFLAVKKQGAPVTAEENGSGAPALIGLAEGSLAPGWSAQQTTHFTAGAGRGLHGAACSAPDTDFWFPGASTAEDRSDYLHLTNPDDAAAVVDIELYGKDGALDSEVGEGIQVPPRSSVPVLLSTLTGKPQTNLTVHVTARSGRVAAAVQALDQKVGGDWLTPSAEPSASVVLPGIPKDATAVRLVAFAPGSADADLKVSLAGPNGSLSPAGNETLHLKSGMTTAVDLADVTRGEPGSLVLTPTGDSGETPVVAAVRVIRGKGADQESAFIPAARPVGDRATVTGNGAKGTYLSLTAPGKAAKVRVTASAGTGGGTAATKTYSVGAGRTLAADVPLPDSLKGTYALTVETVSGGPVHASRTLTLSGAAADGISMFTVQNLTDDRGTVTVPAARPEMGVLLD
>NZ_CP016824.1|WP_067415187.1|4632502_4636261_+|glycosyltransferase
MSVHSHSAAYPAASAGSMSDPAATMTATPTSLPGLDPTSAPAYARHVVTAVLVTHDGARWLPDALAGLLAQERPVQNAVAADTGSADDSARLVADAFGDDRVLHLARRTGFGTAVDEAVRAAGVLTPDDLPYLKRPGGWDPVARQWHDENYDLPELPYGEPEQWLWLLHDDCAPAPDALAGLLAAVEAEREAGGEVAIVGPKLRGWYDRRQLLEVGVTIAHSGRRWTGLDRREQDQGQHDHVRPVLSVSTAGMLIRRDVYEELGGFDRALPLMRDDVDLCWRAQAAGHRVLIAPDAVLRHAEAASRERRTVDCAGRGTTSPHRVDKAGAVHTLLVNSRGAALPWVLLRLIVGTVARTLAYLVGKVPGQAVDEISGLLGTLLRPGRILNARRRRGKGTVEPAELRPLFPPPGATVRATVEQVAGNLTRGSDADAPGAGRHGGAVESGPGGDDADFLEVEQFARLKRLARRPGPVLFAVLLLASLVACRALLGGGALAGGALLPVPDQLGDLWGRYADGWHAVGTGTTEPAPPYLALLATLAALLFGSTHTAVTVVLVASVPLAGFAAYLASGSLVPSRLLRAWGSVVYAFLPAVTGALAGGHLGTAVLAVLLPVMARAGLSAAGLLGHPGTWRATWAYTLLLTLATAFTPMVWPLALVLGIGVLVVRRSALGTYAPRFVAQFATPLLVLAPWSLTLLPFGFFQTAGLDTATGGAGPLDLLGASPGGPGTLSAVLFLGVVAAALGALLREERRRAILTAWAVALTALLFAVLANASAWAGPATLVQGAALLGAALVGADGARHRVAEQSFGWRQPLAALIALACALGPAAAALTWMAAGADGPLERRDPVQVPAFVAEESRTQDQARTLVLAGDSATEVSYALVRGSGGRLGDAELAAAAGTDDRLSTVVARLVAGSGADQADQLGGFAVRYVLVRDGSPREMSRVLDSTPGLTRLSQQDGSALWRVDRQVSRAAVVAKDGSGEPLPVAAGPVELHTDLPAGPAGRVLRLADTADPGWTATLDGEPLERVTVDDWAQGFTLPEGGGRLDVTFEDPFTHTVWIWTQGFLGLVLVVLALPGRRRTVDDDMPDEPAPVPAQPVEGEGRRARRLRAQAEAEADDAAPDAAPEADIPEQREPPGGEPDPAWTAAPEPYEPVDPQQGGYDPYGYQNQGYDQSPQGYPPQPGYDPNAYDPYQQQPQDPYQQGGWQQGQQGYPGYEQQPQQGYGPGQAAPEYGQYEQPPHGHGRERPDGSQQ
>NZ_CP016824.1|WP_003950432.1|4631555_4631819_+|WhiB-family-transcriptional-regulator
MTELFEQLLVEEADEELGWQERALCAQTDPESFFPEKGGSTREAKKVCLACEVRSECLEYALANDERFGIWGGLSERERRRLKKAAV
>NZ_CP016824.1|WP_067415185.1|4630191_4630704_-|cysteine-dioxygenase
MNQDSDPQIAGDLLEVQHLLRPAPEHPSTVAGFVRLARTVAADRARWAPLVAYDPTSRWYHRLETGPGYEVWLLSWLPGQGSGAHDHGRSAGVMTVLDGALTEHTPGGRQVLRPGGHRVVAPGHAHEVVNDALEPAVSLHVYFPGLTTMPVRTLERSATTPAEEPARLTH
>NZ_CP016824.1|WP_008415641.1|4644773_4644956_+|hypothetical-protein
MALEAGLLEILACPACHAPLEESKTASTPELLCTGEGCALAYPIRDGIPVLLVDEARRPA
>NZ_CP016824.1|WP_067415201.1|4645210_4646368_+|mannose-6-phosphate-isomerase
MFDETLLDDPEALTRADPRGLLRDAAGAGARVRTAARLAAEAGITELHPDGRPRTVLIAGPGTAATATADLLGTLAGGACPVVPLGPTGVAAAAGALRWTLPGWAGPVDLLLIATPDGGEPGLALLAEQAYRRGCTVVAVAPDRTPVSEAVQGAHGLAVPMATAPGELPEEEPVEAYANGTTAASGALWALLTPLLLLLGRTGLVDADTDAVHDLADRLDTTAERCGPAVAAYSNPAKTLAAELAESLPLVWTEGPGAGPIGRRFTALLAEVAGHPALTAALPEALPAHGALLVSGIADASDPDDFFRDRVDEPEPLRARVVLLRDRPPGGLTAAPAARELALAHNTALSELEPGEGSDLAATAELIATTDFAAVYLALATPPRS
>NZ_CP016824.1|WP_067415204.1|4646488_4647652_+|mannose-6-phosphate-isomerase,-class-I
MDRLQNTVRPYAWGSVTAIPHLTGTEPTGEPQAELWMGAHPGAPSLVDRGTGPRSLAELIAADPDRELGPAVAARFGPQLPFLLKLLAADAPLSVQVHPDSDQAAAGYADEEQRGVPRTAPERNYKDPHHKPELICALTPFEGLCGFRDPAEAADTLAALDLDSLKPYVDLLHAHPEEAALREVLTAVLTADRDEMAATITEAAAASARLGGPHATYADLARHYPGDPGVLAAMLLNQVSLQPGEALYLGAGVPHAYLSGLGVEIMAASDNVLRCGLTPKHIDVPELLRIVRFDPATPGVLRPEASPDGEEVYDTPVHDFRLSRYVLAPGAPVRDLTLPTPQILLSTEGSPTVGELPLGPGQSVFVPAGEPVELRGPGTVFRATALT
>NZ_CP016824.1|WP_067415206.1|4647772_4648744_+|cation-diffusion-facilitator-family-transporter
MSASGGTKAIVAALSANLAIAVAKFVAFLFSGSSSMLAESVHSLADSGNQGLLLLGGKRAKRQATPEHPFGYGRERYIYAFLVSIVLFSVGGMFAIYEGYEKIKHPHELEHWYWPVGVLVFAIIAEAFSFRTAIKESNPLRGKQSWSQFVRRAKAPELPVVLLEDLGALVGLILALGGVGLALATGDGVWDGIGTLCIGVLLIVIAIVLAAETKSLLLGESAGLDEVRKIEAALVDGDTVTRVIHMRTLHLGPEELLVAAKLAVQHDDTAAEVAAAINAAEARIREAVPIARAIYLEPDIYDEAAAAKGTNPGMTPSPDASPR
>NZ_CP016824.1|WP_003950444.1|4648980_4650435_+|adenosylhomocysteinase
MASAQQHDFKVADLSLAEFGRKEITLAEHEMPGLMSIREEYAASQPLAGARVTGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAIAVGPNGTPDNPQGVPVFAWKGESLEEYWWCTEQALTWPNTPTGGPNMILDDGGDATLLVHNGVQYEKDGKVPDPVTAESDEHRVILQLLTRTLGENPQKWTQLASEIRGVTEETTTGVHRLYEMQRDGQLLFPAINVNDAVTKSKFDNKYGCRHSLIDGINRATDVLIGGKTAVVCGYGDVGKGCAESLRGQGARVIVTEIDPICALQAAMDGYQVATLDDVIGQADIFVTTTGNKDIIMAADMAKMKHQAIVGNIGHFDNEIDMAGLAAIPGIVKDEVKPQVHTWTFPDGKVIIVLSEGRLLNLGNATGHPSFVMSNSFADQTLAQIELFTKPDEYPTDVYVLPKHLDEKVARLHLDALGVRLTTLRPEQAAYIGVSVEGPFKPDHYRY
>NZ_CP016824.1|WP_067415209.1|4650576_4651200_+|hypothetical-protein
MPKGRYSLHDPHDHTPLAEEHFHCAPGPHGWRYVAQLTTPAPENDHLGSVDLTLDDLGRPLRLELHSGGWQVRGGALEGVTWVRTDPTGEEATEGTVAAHTFTGNSPAFLVATARLLRLTTTSPPTRVRLVSFTGQALAPRTLDQQWALRSSETHATDNGALTVDEYLVGDVETGEQHTVHLAGDVILSAPGIELEDLETPPTRFTD
>NZ_CP016824.1|WP_067415211.1|4651214_4652144_-|RDD-family-protein
MAGGEAETVSGPVTGEAVALELRPAKLLSRGAAVLIDLAVTWLVFLLVMVGVLVTTASLDEAAVAAVSVAVFLLVPVGGPIAVETLSHGRSLGKWACGLRVVREDGGPIRFRHALVRGAMAVVEILLTVGVVACVASLVSERGRRVGGVFAGTLVVRERIPVARAPELAAPEPWLAQQVNGLDLSSVPDSLWLAVRQYLGRVRQLDAQVAAGMAGRLAEELAVRTGVPVPAGVPAGSYLAAVAYERRERERRKAGALPRDVAEGEVPGGGAGAVPEARGVGEEISPAVGGGGGEGRSGGQAGTGFVPPV
>NZ_CP016824.1|WP_008415631.1|4652215_4653220_+|stage-II-sporulation-protein-M
MDLDVFVAAHEAEWRRLETLLRRRRLTGPEADELVSLYQRATTHLSLISSAAPDPQLTGRLTRLVARARSKVTAPRRARARDLTGFLAHDFPAALYRTRTWWAPTAVASLLVAALIGWWVATHPEVRSAIAAPAELRELTRPGGDYEAYYSSHPATSFAAQVWTNNAQAAALCLVLGAFLCLPVVAVLLLNMVNIGVGIGLMASAGRLDTFLGLLVPHGLLELTAVFVAAGTGLRLGWTVIDPGPRRRRDALAQEGRAALGMALGLALVLLVSGVIEAFVTPSGLPTWARITIGTTAEAAFLIYVYAVGGRAARAGRTGDLTADETGSGVPVAT
>NZ_CP016824.1|WP_067415213.1|4659066_4660374_-|DUF58-domain-containing-protein
MALTGRTALLAALGSLPVALLEPSWLGGAAVNSPLAVAMMCDYALAAPVRKLRFTRSGDTHVRQGEMAETCLQLTNTSSRPLRALLRDAWPPSNAVPGATDAARHRVEVPAGGARELHTQLRPTRRGEAVAHSVTVRSYGPLGLVSRQATHPVPGSLRVLPPFHSRRLLAAKTARLRELDGRTSALGRGEGTEFDSLRRYVPGDDTRSIDWRATARRSEVAVRTWRPERDRRVLIVLDTGRTSAGRVGNAPRLDAAMDAALLLAALASRAGDRVDLLAFDRELRAQVRGKAAPQLLPALVDGPASLEPQLVETDARGLAAEILRSTPRRALVVLLTTLDTTPVEEGLLPVLGRLTDRHTLLVASVADPRLAEMAAARGTVEKVYQAAAAHKAQAERDRTAGLLRRRGVMVVDAPPADLASALADAYLSAKVAGKL
>NZ_CP016824.1|WP_008409130.1|4660386_4661367_-|MoxR-family-ATPase
MSAPTPDADGATEARAALEAVRAEIGKAVVGQDPVVTGLVIALLCRGHVLLEGVPGVAKTLLVRALAAAVELETKRVQFTPDLMPSDVTGSLLFDARTSEFSFQPGPVFTNLLLADEINRTPPKTQASLLEAMEERQVTVDGTARHLPEPFLVAATQNPVEYEGTYPLPEAQLDRFLLKLNVSLPPRDDEIALLSRHARGFDPRDLSAAGLHPVVGPAQLDAARSAVAGTSVSPEIAAYIVDVCRATRDSPSLSLGASPRGATALLSTARAWAWLTGRDYVTPDDVKALALPTLRHRVQLRPEAEMEGVTPDAVLTSLLARVPVPR

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Crispr_ID: NZ_CP016824_29

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_29

4788484-4788570

Orphan

Consensus_repeat	Method
AGCCCGGCCGGCGTTTGAGGCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_29

>merge|NZ_CP016824|29|4788484-4788570|CRISPRCasFinder
AGCCCGGCCGGCGTTTGAGGCCAGTCTTTGACCGGCACGGTCGAGAGGGAGCCCGGCACCCAACAGCCCGGCCGGCGCTTGAGGCCA

>NZ_CP016824|29|25|4788484-4788570|CRISPRCasFinder
AGCCCGGCCGGCGTTTGAGGCCA	GTCTTTGACCGGCACGGTCGAGAGGGAGCCCGGCACCCAAC
AGCCCGGCCGGCGCTTGAGGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_015507171.1\|4783520_4784198_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP016824.1\|WP_075986402.1\|4779842_4781252_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273050
NZ_CP016824.1\|WP_030773136.1\|4791931_4793041_+\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380492
NZ_CP016824.1\|WP_003950546.1\|4776370_4776841_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP016824.1\|WP_003950547.1\|4776973_4778137_+\|4-hydroxyphenylpyruvate-dioxygenase	unknown	unknown	gnl\|CDD\|273528
NZ_CP016824.1\|WP_067415350.1\|4782124_4783441_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP016824.1\|WP_010642691.1\|4793412_4794858_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP016824.1\|WP_008406543.1\|4785004_4787410_+\|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl\|CDD\|368494
NZ_CP016824.1\|WP_008406550.1\|4790880_4791195_+\|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl\|CDD\|178809
NZ_CP016824.1\|WP_067415359.1\|4791194_4791797_+\|DUF2017-domain-containing-protein	unknown	unknown	gnl\|CDD\|378185
NZ_CP016824.1\|WP_003950555.1\|4788615_4789206_-\|nicotinamidase	unknown	unknown	gnl\|CDD\|238493
NZ_CP016824.1\|WP_067415357.1\|4787532_4787871_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_018895892.1\|4784297_4784558_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_008414233.1\|4781336_4781813_-\|SsgA-family-sporulation/cell-division-regulator	unknown	unknown	gnl\|CDD\|377399
NZ_CP016824.1\|WP_067418205.1\|4789314_4790643_-\|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236426
NZ_CP016824.1\|WP_003950561.1\|4794958_4795393_+\|M67-family-metallopeptidase	unknown	unknown	gnl\|CDD\|163701
NZ_CP016824.1\|WP_067415344.1\|4778227_4779664_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_CP016824.1\|WP_003950565.1\|4797298_4798048_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293802
NZ_CP016824.1\|WP_067415362.1\|4796068_4797019_+\|cysteine-synthase	unknown	unknown	gnl\|CDD\|273463
NZ_CP016824.1\|WP_003950563.1\|4795784_4796069_+\|MoaD/ThiS-family-protein	unknown	unknown	gnl\|CDD\|340594

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_015507171.1\|4783520_4784198_+\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	1.53759e-26
NZ_CP016824.1\|WP_075986402.1\|4779842_4781252_+\|FAD-binding-protein	gnl\|CDD\|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	7.22204e-139
NZ_CP016824.1\|WP_030773136.1\|4791931_4793041_+\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380492	cd06268, PBP1_ABC_transporter_LIVBP-like, periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. They are mostly present in archaea and eubacteria, and are primarily involved in scavenging solutes from the environment. ABC-type transporters couple ATP hydrolysis with the uptake and efflux of a wide range of substrates across bacterial membranes, including amino acids, peptides, lipids and sterols, and various drugs. These systems are comprised of transmembrane domains, nucleotide binding domains, and in most bacterial uptake systems, periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. These PBPs bind their substrates selectively and with high affinity. Members of this group include ABC-type Leucine-Isoleucine-Valine-Binding Proteins (LIVBP), which are homologous to the aliphatic amidase transcriptional repressor, AmiC, of Pseudomonas aeruginosa. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group.	9.09063e-37
NZ_CP016824.1\|WP_003950546.1\|4776370_4776841_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	9.3337e-27
NZ_CP016824.1\|WP_003950547.1\|4776973_4778137_+\|4-hydroxyphenylpyruvate-dioxygenase	gnl\|CDD\|273528	TIGR01263, 4-hydroxyphenylpyruvate_dioxygenase, 4-hydroxyphenylpyruvate dioxygenase. This protein oxidizes 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic (see . In some bacterial species, this enzyme has been studied as a hemolysin. [Energy metabolism, Amino acids and amines].	9.18263e-179
NZ_CP016824.1\|WP_067415350.1\|4782124_4783441_+\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	1.07831e-23
NZ_CP016824.1\|WP_010642691.1\|4793412_4794858_+\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NZ_CP016824.1\|WP_008406543.1\|4785004_4787410_+\|M6-family-metalloprotease-domain-containing-protein	gnl\|CDD\|368494	pfam05547, Peptidase_M6, Immune inhibitor A peptidase M6. The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homolog of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae.	0
NZ_CP016824.1\|WP_008406550.1\|4790880_4791195_+\|ATP-dependent-Clp-protease-adapter-ClpS	gnl\|CDD\|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	1.58339e-41
NZ_CP016824.1\|WP_067415359.1\|4791194_4791797_+\|DUF2017-domain-containing-protein	gnl\|CDD\|378185	pfam09438, DUF2017, Domain of unknown function (DUF2017). This is an alpha-helical domain found in gene neighborhoods that contain genes encoding ubiquitin, cysteine synthases and JAB peptidases.	3.47766e-56
NZ_CP016824.1\|WP_003950555.1\|4788615_4789206_-\|nicotinamidase	gnl\|CDD\|238493	cd01011, nicotinamidase, Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).	9.1451e-71
NZ_CP016824.1\|WP_003950561.1\|4794958_4795393_+\|M67-family-metallopeptidase	gnl\|CDD\|163701	cd08070, MPN_like, Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding). This family contains archaeal and bacterial MPN (also known as Mov34, PAD-1, JAMM, JAB, MPN+)-like domains. These domains contain the signature JAB1/MPN/Mov34 metalloenzyme (JAMM) motif, EXnHS/THX7SXXD, which is involved in zinc ion coordination and provides the active site for isopeptidase activity for the release of ubiquitin from ubiquitinated proteins (thus having deubiquitinating (DUB) activity) that are tagged for degradation. The JAMM proteins likely hydrolyze ubiquitin conjugates in a manner similar to thermolysin, in which the zinc-polarized aqua ligand serves as the nucleophile, compared with the classical DUBs that do so with a cysteine residue in the active site.	1.90861e-37
NZ_CP016824.1\|WP_008414233.1\|4781336_4781813_-\|SsgA-family-sporulation/cell-division-regulator	gnl\|CDD\|377399	pfam04686, SsgA, Streptomyces sporulation and cell division protein, SsgA. The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division.	1.39691e-40
NZ_CP016824.1\|WP_067415344.1\|4778227_4779664_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	5.5469e-09
NZ_CP016824.1\|WP_067418205.1\|4789314_4790643_-\|nicotinate-phosphoribosyltransferase	gnl\|CDD\|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NZ_CP016824.1\|WP_003950565.1\|4797298_4798048_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293802	cd07716, RNaseZ_short-form-like_MBL-fold, uncharacterized bacterial subgroup of Ribonuclease Z, short form; MBL-fold metallo-hydrolase domain. The tRNA maturase RNase Z (also known as tRNase Z or 3' tRNase) catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors. Two forms of RNase Z exist in eukaryotes, one long (ELAC2) and one short form (ELAC1), the former may have resulted from a duplication of the shorter enzyme. Only the short form exists in bacteria. Members of this bacterial subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	4.14449e-84
NZ_CP016824.1\|WP_067415362.1\|4796068_4797019_+\|cysteine-synthase	gnl\|CDD\|273463	TIGR01136, Cysteine_synthase, cysteine synthase. This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family].	2.81095e-138
NZ_CP016824.1\|WP_003950563.1\|4795784_4796069_+\|MoaD/ThiS-family-protein	gnl\|CDD\|340594	cd17074, Ubl_CysO_like, ubiquitin-like (Ubl) domain found in Mycobacterium tuberculosis CysO and similar proteins. CysO, also termed 9.5 kDa culture filtrate antigen cfp10A, together with CysM (Cysteine synthase M), forms a protein complex CysM-CysO that represents a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. The replacement of the acetyl group of O-acetylserine by CysO thiocarboxylate to generate a protein-bound cysteine is catalyzed by CysM in a pyridoxal 5?-phosphate (PLP)-dependent manner. The family also includes QbsE that functions as the sulfide donor for the biosynthesis of thioquinolobactin in Pseudomonas fluorescens. A JAMM motif protein QbsD catalyzes removal of the carboxy-terminal dipeptide from QbsE. Both CysO and QbsE are similar to prokaryotic sulfur carrier proteins such as ThiS and MoaD, containing the beta-grasp ubiquitin-like fold.	6.6805e-42

>NZ_CP016824.1|WP_067415357.1|4787532_4787871_+|hypothetical-protein
MAAGGFVRMPGGSVVVALSLPAPPPGGGRGEQRVRVLVHAKNRARALTRLRNLGLRAVYLRGNGAPPTPDEITAVLHHPDGLIWRAAAPAPAGDLSVSRAPELWRPIRALLA
>NZ_CP016824.1|WP_008406543.1|4785004_4787410_+|M6-family-metalloprotease-domain-containing-protein
MSRHRRAFRATALSVAIAAIGATTAAVGTAQAADRPAGDDQAVERRDPAPAKGHVEHNLEGPFSEKQEKQRGEALRQLISGDKKASQRDGSRVLRLDDGKYVELGREKTDQIFTILVEFGDKVDDTTMYDPDGPEGPEEPVVKYGGEPGPLHNQIAEPDRKNDNSTDWKADFSRDHFQDLYFSTEKNKESVKKYYEKQSSGRYSVDGEVTDWVKVDYNEARYGSNYCGDTNCANVWDVVRDGVNQWAADQKAAGRSDAEIKEQLAKYDTWDRYDFDGDGDFNEPDGYIDHFQIVHAGEDESAGGGAQGTDAIWAHRWYAYGTDAGKTGPAGNKAGGAQIGDTGIWVGDYTVQPENGGLGVFAHEYGHDLGLPDHYDTSGAGENSTAFWSLMSSGSWLGTGKTEIGNLPGDMTAWDKLQLGWLDYATAKAGTRSTHKLGVAEYNTKDKQALVVELPEKEVTTTITEPAEGSSQWWSDSGDDLKNTLTRPVDLTGKSAATLDLQGWWNIEENYDFLYTEVSTDGGANWTALDGTVDGKPLPRDGGDTPALHGVSDGYRALSFPLDAYAGQQIELRFRYQTDGGLAEPGFAADAISLTADGEELFADGAEDGDNGWTAKGFQRIGASFTQDYPQYYIAENRQYVSYDTTLKTGPYNFGWTSTRPDWVEHFPYQNGLLIWLWDTSQKDNNTGVHPGEGRVLPVDAHPKAEKWADGTIMRNRIQAYDAPFSWYPTQGFTLHQDGKPAKVKPKLGIPVFDDGFPGRYYDAANPTGSVKVTDTNTRITITKEPLSGKTITVKVGPSLK
>NZ_CP016824.1|WP_018895892.1|4784297_4784558_-|hypothetical-protein
MARPTPAQYATGTATVVLATLALLLLTGTTGGAGVALIAAAALGLGLGAACAVARARPAAPAGTRHEAVRHHAGVAVPGGERGLRG
>NZ_CP016824.1|WP_015507171.1|4783520_4784198_+|RDD-family-protein
MTTEPPPPGSGNSPDDDPFRKPPPSGAGSPYDPPPQGGGGGDPYGGNPYDNPPPPGGGGPYGPAGGGGPYGGDPLAGMPPLAPSGKRVLARVIDMIIVGVVVWLLSMLFNVGTWDSDVDNIDAGKSFGQSLIAAILYIAYDTILTARTGQTVGKRLLHLRVADLSNGATPSTQTSLIRAVVLWLPFAFCCACIWTIICGGWSFFDRPYKQGLHDKAAKTVEVTTG
>NZ_CP016824.1|WP_067415350.1|4782124_4783441_+|RDD-family-protein
MSAPTPAPGDDRPRPAYYPDPSIPGYIRYWNGASWVPGTSRPAPAAGEPLPAPPPGSVPATPAPPEETGPVFLDEDPAAPSAEGPARDSAWGADPARQSGFGGAPDHRVSWGGPEPAVPDPRTGEPAAPAKPVEGTLTFRRPSGPVAPAARRETAGPSGLAQSPVDPRGTSAPATPTTPAPRQDPGTLPIRALPRTPAPATEQPAAPAVPQPRPAPAPAPVQQPAPVQPGWAQQPPAPAAPAAPAVPVAPARGDENVPVVPWKPPVEDPFLAAARAQAAARPAGLGRRLAARLVDTLVVGAVTAAAAVPLASAARDHLDAKIEAAKLSGRTVTVWLLDGTTAGYLAAVLAVLLLFGVVYEALPTAKWGRTLGKKLFGLRVQDIEEHDVPAFGAALRRWLVYSVSGLLVVGVAGVLWCLFDRPWRQCWHDKAARTFVAR
>NZ_CP016824.1|WP_008414233.1|4781336_4781813_-|SsgA-family-sporulation/cell-division-regulator
MNTVVERELELRLVLSPERSIAVPARLVYAAADPFAVSVTFHLGSQNPVHWTFARELLVEGVFRPCGHGDVRIWPSKVGGRNVLLMALSSPDGDALLQAPSVAVSAWLDRTLTLVPPGTEHERLEMDAGLARLLEPAPADDLWRGDPWSEEAPGPDGE
>NZ_CP016824.1|WP_075986402.1|4779842_4781252_+|FAD-binding-protein
MPAPPAAEPPAPTGPTALLDRLREGLPAEAVLTDPDVTAAYAHDMASFCEAGKPAAVVLPRTTEQVQHVMRTATAFRVPVVPQGARTGLSGAANAVDGCLVLSLVKMDRVLEIDPVNRIAVTEPGVVNAVLSRAVEEHGLSYPPDPSSWETCTIGGNIGTASGGLCCVKYGVTAEYVLGLDVVLADGRLLTTGRRTAKGVAGYDLTRLFVGSEGSLGVVVKAVLALKPRPPRQLALAAEFPSAAAAGDAVCRIMAEGHTPSLLELMDRTTVRAVNAMARMGLPETTEALLLAAFDTPDPAADLAAVGALCEAAGATGVVPADTEAESELLLAARRMSLVALEAVKGTTMIDDVCVPRSRLAELLEGVEEIAARYDLTIGVCAHAGDGNTHPTVCFDATDADEARRARESFDAIMALGLELGGTITGEHGVGVLKKEWLARELGPTGVEVQRSLKAALDPLGLLNPGKLF
>NZ_CP016824.1|WP_067415344.1|4778227_4779664_-|tetratricopeptide-repeat-protein
MARAPRPRLPQGVPGAPPPPAARRPRRRGPRLSAAVGVGLLLAGGGVVAVDRLGQDRAAPAPLTPAGRALAAAGAGRPAALADLAALIGERRERVRRAPADRASWAVLGAALAERAARSGAPGAYTEAERALQRALAQGGTPDVRALTGLAVLAAARQDWAGAVRWGEAARDRAPGRVGAYRVLLEAYPGTGDAEGADRALERLRKVRPGPVAEVAAAWVHRERGWREDAEATVYDAAARAATPAERAAALSRAGDLAWERGEAETALARYEGALRAEPEHDGAAAGRARALAGLGRSEEALTAWARARAAAPRPGYAVESGELLLALGRSAEAADHFSLARHQAAALARDGVRQEPVLGRLEADHGDPAEAVRLLTEEHRRHPGPAASGALGWALHKAGRSAEALPRLRAAVKDGPNTARPAYHLGMVHLALGERGAARRQLTRALRLAPQFSPLHAERARRELAALGEPAWGPPPA
>NZ_CP016824.1|WP_003950547.1|4776973_4778137_+|4-hydroxyphenylpyruvate-dioxygenase
MAATSTNPQAPQSAPTTAREADPFPVKGMDAVVFAVGNAKQAAHYYSSAFGMKLVAYSGPENGSRETASYVLENGGARFVLTSVIKASTERGAFLESHVAAHGDGVVDLAIEVPDARAAYAYAVEHGATGLEEPHEVKDEHGTVVLAAIATYGKTRHTLVERSGYSGPYLPGYVAADPIVAPPAKRTFQAIDHCVGNVELGKMNEWVAFYNKVMGFTNMKEFIGDDIATEYSALMSKVVADGTLKVKFPINEPAIAKKKSQIDEYLEFYGGAGVQHIALATNDIVQTVRTMRDAGVQFLDTPDSYYDTLGEWAGETRVPVETLRELKILVDRDEDGYLLQIFTKPVQDKPTVFFEMIERHGSMGFGKGNFKALFEAIEREQDRRGNL
>NZ_CP016824.1|WP_003950546.1|4776370_4776841_-|Lrp/AsnC-family-transcriptional-regulator
MGIDELDGRLIVLLAREPRIGVLEASRRLGVARGTVQSRMDRLQSNGVIRGFGPDVDPAALGYRVTAFATLEIRQGQGPDVRAHLAQVPEVLELHTITGEGDMLCRLVARSNGDLQRVIDRVVGFDGIVRAATAIVMENPVPLRVIPLVEQAARET
>NZ_CP016824.1|WP_003950555.1|4788615_4789206_-|nicotinamidase
MRRALIVVDVQNDFCEGGSLAVTGGAEVAAAITEHLDGPGRELYDHVVATRDHHIEPGDHFSARPDFRDSWPVHCVAGTEGAGFHPAFAPALVSGAVEAVFDKGAYSAAYSGFEGVDENGVGLADWLRGQGVTDVDVVGLATDYCVRATALDALAAGFGTRVLLDLAAGVAPDSVATTVTELREAGAVLTGKPAQT
>NZ_CP016824.1|WP_067418205.1|4789314_4790643_-|nicotinate-phosphoribosyltransferase
MRLPVEVPSTALFTDHYELTMLQAALAAGTADRPCVFEVFTRKLPEGRRYGVLAGVGRVLDAVEHFRFEPAQLDHLRAHDVVDEATLDYLAGYRFSGTISGYPEGEVYFPGSPVLRVEGTFAECVLLETVILSILNHDSAIAAAASRMSSAAAGRPLIEMGARRTHELAAVAASRAAYIGGFTTTSDLAAGFRYDIPTTGTSAHAFTLLHDNERDAFEAQVAALGRGTTLLVDTYDVQEAVRTAVEVAGPELGAVRIDSGDLLLVAHRVRDQLDRLGARDTRIVVTSDLDEYAIASLAAAPVDAYGVGTQLVTGSGHPTCSMVYKLVARARYTEPGAPLEPVAKKSLGGKTSLGGRKWAARRRDAEGVAEAEVVGTGPVPPELADAQLLVELVRDGEVVGREPMDVARERHAAARAALPLSATQLSKGEPVIPTEYVAPQPG
>NZ_CP016824.1|WP_008406550.1|4790880_4791195_+|ATP-dependent-Clp-protease-adapter-ClpS
MGRVSVSPAETEQPAAAEETFAVPEPDLPWVTLVHNDPVNLMSYVAYVFQAYFGYSKEKANKLMLDVHHKGRAVVSSGSREEMERDVQAMHGYGLWATLQQDRA
>NZ_CP016824.1|WP_067415359.1|4791194_4791797_+|DUF2017-domain-containing-protein
MAGYFEPTEKGAAAALDAVEISIIRSLAVQLLELIGPGDDHLGDDPLAELFAEGPSEAPTDPVLRRLFPDAYADPATAATAQEAEELRARSAEFRRFTENDLRAAKRESALLVVRTLDAVPVDSEGGGTVELTPDQSRQWIGALNDLRLAIAARLDLRDESDTDELFQLPDSDPRKPMVIAQLWLAGLQESLIETLTAGS
>NZ_CP016824.1|WP_030773136.1|4791931_4793041_+|amino-acid-ABC-transporter-substrate-binding-protein
MSPPPPHTTPESGPPPVPLGALVPLTRPGWTEAGRHLLAGLELGVDEVNAAGGIGGRPLELLVRDTAADPGRAEAAVEELAGLGVAAVAGEYHSVVARAAAVRAEALGVPFLCSSAVLDALTEEPATWVARLAPAQSHGWRSYAGFLLAAGHRRIAVARQASLYWETGTRILRDHLGQRGGSVTELDADALTPRELCDALAEDGATALLLLAGTPQPAVPLVRAVRADRRLDGVLVGAPAGQPEFPRWLAALGADGAGVPFLRYLPERPGPPAVRVGEALRARLGEEPSFVAYEGWDTVAVLAGALRTYGTGRADVARAWEGGAVAGTRGEIRFSRLPGIGVRQWVWPPVQVADRDPAEPGRFRVLHQG
>NZ_CP016824.1|WP_010642691.1|4793412_4794858_+|amino-acid-permease
MSSTQVDTVSDGEPGPGRGGPSTPHGGEGYQRGLGARQIQMIAIGGAIGTGLFLGAGKAISKAGPSLILAYAIAGLVIFFIMRALGELLMYRPVSGSFSEYAREFIGPFAGFVTGWTYWLFWVVTGITEVTAAAQYMTYWFDVPQWVSALLFTIILYGANLISVKIFGELEFWFSMVKVTAIVGMILICVGILTLGFSDAGDTATVAHLWNQGGFFPEGIGGTLMTLQIVMFAFLAVELVGVTAGESKDPEKTLPKAINTVPWRIAVFYVGALVMILSVVPWTEFQPGISPFVAAFEKMGLGVGAAIVNFVVLTAALSSCNSGMYSTGRMLRDLALNGQGPKFFTRLTRSGTPLVGTTFSAALMMVGVWINYQWPGEAFNYVVSFATISGMWAWVMILVCQIRYRAKADRGELPVSSFRAPGAPFTSWFALCFLALVVVMMGIDPDTRISLYCAPLWAAILLVSYRVLRSRDPQNAAFAKR
>NZ_CP016824.1|WP_003950561.1|4794958_4795393_+|M67-family-metallopeptidase
MLTLTQALHDQIVAHARADHPDEACGIVAGPAGSGRPERFIPMLNAARSPTFYEFDSMDLLKLYRELDDRDEEPVIVYHSHTATEAYPSRTDVTYANEPGAHYVLVSTADTDDAGPFQFRSFRIVDGEITEEDVQVVAAYPAAG
>NZ_CP016824.1|WP_003950563.1|4795784_4796069_+|MoaD/ThiS-family-protein
MAIEVRIPTILRTYTDGAKTVEGSGTTLAELIDDLETRHAGIKERIVDGDQLRRFVNVYLNDEDVRFLDSIDTKVADGDNVTILPAVAGGSAAL
>NZ_CP016824.1|WP_067415362.1|4796068_4797019_+|cysteine-synthase
MRYDSPLAAVGNTPLVRLPRLSPSDDVRIWAKLEDRNPTGSVKDRPALHMVEQAEKDGRLTPGCTILEPTSGNTGISLAMAARLKGYRIVCVMPENTSQERRDLLAMWGAEIVSSPAAGGSNTAVRVAKELAAEHPDWVMLYQYGNPDNAGAHYATTGPEILADLPSVTHFVAGLGTTGTLMGVGRYLREQKPGIAIVAAEPRYDDVVYGLRNLDEGFVPELYDASVLTSRFSVGSADAVSRTRELLQQEGIFAGVSTGAALHAAIGFGRKAVKAGESADIVFVVADGGWKYLSTGVYTAATTEEAIETLHGQLWA
>NZ_CP016824.1|WP_003950565.1|4797298_4798048_+|MBL-fold-metallo-hydrolase
MKLTVVGCSGSFPSAESACSSYLVEADGFQLLLDMGNGALGELQRHTGLYDLDAVFLSHLHADHCIDMCAYFVARYYRHGDGPCDALPVYGPEGTQQRLITAYGDSSAEHMPEVFDFRTLKEDAFDLGPFRIRTVRVPHPVEAYAIRVEHDGRSLTYSGDTGPCAELDALAAGTDLYLCEAAFTHGKENIPDLHLNGREAGESAQRAGAGRLLLTHIPPWTDPRTNLTDAREVYDGPAALAEPGVTYTV

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Crispr_ID: NZ_CP016824_30

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_30

5008810-5008897

Orphan

Consensus_repeat	Method
GGCCTCAAGCGCCGGCCGGGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_30

>merge|NZ_CP016824|30|5008810-5008897|CRISPRCasFinder
GGCCTCAAGCGCCGGCCGGGCTGTTTTTCGGGGGTGCTCGCCGCTTTCGCGCGCCGGTCACCGATGGCCTCAAGCGCCGGCCGGGCTT

>NZ_CP016824|30|26|5008810-5008897|CRISPRCasFinder
GGCCTCAAGCGCCGGCCGGGCTG	TTTTTCGGGGGTGCTCGCCGCTTTCGCGCGCCGGTCACCGAT
GGCCTCAAGCGCCGGCCGGGCTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_031177207.1\|4997048_4997582_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239646
NZ_CP016824.1\|WP_067415584.1\|5017742_5018390_+\|hydrolase	unknown	unknown	gnl\|CDD\|226101
NZ_CP016824.1\|WP_010642418.1\|5007023_5008757_+\|sel1-repeat-family-protein	unknown	unknown	gnl\|CDD\|276807
NZ_CP016824.1\|WP_010642433.1\|4996232_4996985_+\|AIM24-family-protein	unknown	unknown	gnl\|CDD\|376704
NZ_CP016824.1\|WP_003950752.1\|5012901_5013225_-\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|224987
NZ_CP016824.1\|WP_079165381.1\|4999344_5000526_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187551
NZ_CP016824.1\|WP_067415563.1\|5009272_5009689_-\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|223806
NZ_CP016824.1\|WP_067415575.1\|5013352_5014369_-\|ribosome-small-subunit-dependent-GTPase-A	unknown	unknown	gnl\|CDD\|206747
NZ_CP016824.1\|WP_067415558.1\|5002781_5003342_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_030306203.1\|4997578_4999060_-\|zinc-dependent-metalloprotease	unknown	unknown	gnl\|CDD\|378392
NZ_CP016824.1\|WP_067415572.1\|5012318_5012936_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP016824.1\|WP_003950755.1\|5015781_5016504_-\|M50-family-metallopeptidase	unknown	unknown	gnl\|CDD\|315961
NZ_CP016824.1\|WP_067415555.1\|5001586_5002687_+\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|226011
NZ_CP016824.1\|WP_067415581.1\|5016593_5017466_+\|SOS-response-associated-peptidase	unknown	unknown	gnl\|CDD\|376837
NZ_CP016824.1\|WP_067415569.1\|5011368_5012175_-\|histidinol-phosphatase	unknown	unknown	gnl\|CDD\|273949
NZ_CP016824.1\|WP_003950742.1\|5000633_5001116_+\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|238385
NZ_CP016824.1\|WP_067415566.1\|5009836_5011288_+\|catalase	unknown	unknown	gnl\|CDD\|163712
NZ_CP016824.1\|WP_107436696.1\|5003522_5006519_+\|UPF0182-family-protein	unknown	unknown	gnl\|CDD\|377101
NZ_CP016824.1\|WP_008415685.1\|5001303_5001561_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067415578.1\|5014386_5015739_-\|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|235037

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_031177207.1\|4997048_4997582_-\|NUDIX-hydrolase	gnl\|CDD\|239646	cd03674, Nudix_Hydrolase_1, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, U=I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.35278e-40
NZ_CP016824.1\|WP_010642418.1\|5007023_5008757_+\|sel1-repeat-family-protein	gnl\|CDD\|276807	sd00010, SLR, Sel1-like repeat. Sel1-like repeats (SLRs) share similar alpha-helical conformations with Tetratricopeptide repeats (TPRs), but with different consensus sequence lengths and superhelical topologies. SLRs contain 36 to 44 amino acids and are present in bacteria and eukaryotes but not in archaea. SLR proteins are involved in a variety of functions, and many serve as adaptor proteins for the assembly of macromolecular complexes. The SLR family was named after the Caenorhabditis elegans Sel1 protein which is predicted to fold into 11 SLRs, a transmembrane domain, and an N-terminal signal sequence. The human Sel1L protein contains an additional fibronectin type-II domain and an N-terminal PEST sequence. Its downregulation is associated with the development of breast and pancreatic carcinomas.	1.75562e-14
NZ_CP016824.1\|WP_003950752.1\|5012901_5013225_-\|multidrug-efflux-SMR-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	1.53927e-27
NZ_CP016824.1\|WP_067415584.1\|5017742_5018390_+\|hydrolase	gnl\|CDD\|226101	COG3571, COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only].	6.59219e-27
NZ_CP016824.1\|WP_079165381.1\|4999344_5000526_+\|SDR-family-oxidoreductase	gnl\|CDD\|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.72825e-90
NZ_CP016824.1\|WP_067415563.1\|5009272_5009689_-\|transcriptional-repressor	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	4.30188e-37
NZ_CP016824.1\|WP_067415575.1\|5013352_5014369_-\|ribosome-small-subunit-dependent-GTPase-A	gnl\|CDD\|206747	cd01854, YjeQ_EngC, Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases. YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.	4.78995e-88
NZ_CP016824.1\|WP_003950755.1\|5015781_5016504_-\|M50-family-metallopeptidase	gnl\|CDD\|315961	pfam13398, Peptidase_M50B, Peptidase M50B-like. This is a family of bacterial and plant peptidases in the same family as MEROPS:M50B.	3.49482e-64
NZ_CP016824.1\|WP_030306203.1\|4997578_4999060_-\|zinc-dependent-metalloprotease	gnl\|CDD\|378392	pfam10103, Zincin_2, Zincin-like metallopeptidase. This family of proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold. The structure of this family has similarity to Peptidase_M1 (pfam01433, Structure 3CMN).	4.02814e-169
NZ_CP016824.1\|WP_067415572.1\|5012318_5012936_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.41716e-08
NZ_CP016824.1\|WP_067415555.1\|5001586_5002687_+\|PDZ-domain-containing-protein	gnl\|CDD\|226011	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms].	7.50535e-77
NZ_CP016824.1\|WP_067415581.1\|5016593_5017466_+\|SOS-response-associated-peptidase	gnl\|CDD\|376837	pfam02586, SRAP, SOS response associated peptidase (SRAP). The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.	7.13e-95
NZ_CP016824.1\|WP_067415569.1\|5011368_5012175_-\|histidinol-phosphatase	gnl\|CDD\|273949	TIGR02067, his_9_HisN, histidinol-phosphatase, inositol monophosphatase family. This subfamily belongs to the inositol monophosphatase family (pfam00459). The members of this family consist of no more than one per species and are found only in species in which histidine is synthesized de novo but no histidinol phosphatase can be found in either of the two described families (TIGR01261, TIGR01856). In at least one species, the member of this family is found near known histidine biosynthesis genes. The role as histidinol-phosphatase wsa first proven in Corynebacterium glutamicum. [Amino acid biosynthesis, Histidine family].	1.09868e-97
NZ_CP016824.1\|WP_010642433.1\|4996232_4996985_+\|AIM24-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	4.69794e-30
NZ_CP016824.1\|WP_067415566.1\|5009836_5011288_+\|catalase	gnl\|CDD\|163712	cd08156, catalase_clade_3, Clade 3 of the heme-binding enzyme catalase. Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes, which is involved in the protection of cells from the toxic effects of peroxides. It catalyzes the conversion of hydrogen peroxide to water and molecular oxygen. Catalases also utilize hydrogen peroxide to oxidize various substrates such as alcohol or phenols. Clade 3 catalases are the most abundant subfamily and are found in all three kingdoms of life; they have a relatively small subunit size of 43 to 75 kDa, and bind a protoheme IX (heme b) group buried deep inside the structure. Clade 3 catalases also bind NADPH as a second redox-active cofactor. They form tetramers, and in eukaryotic cells, catalases are located in peroxisomes.	0
NZ_CP016824.1\|WP_107436696.1\|5003522_5006519_+\|UPF0182-family-protein	gnl\|CDD\|377101	pfam03699, UPF0182, Uncharacterized protein family (UPF0182). This family contains uncharacterized integral membrane proteins.	0
NZ_CP016824.1\|WP_003950742.1\|5000633_5001116_+\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|238385	cd00756, MoaE, MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.	1.08807e-47
NZ_CP016824.1\|WP_067415578.1\|5014386_5015739_-\|3-phosphoshikimate-1-carboxyvinyltransferase	gnl\|CDD\|235037	PRK02427, PRK02427, 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional.	2.29516e-166

>NZ_CP016824.1|WP_010642418.1|5007023_5008757_+|sel1-repeat-family-protein
MEPADREDTDTGTAEDEVRRLGGAGAGDAASMSVIGAELLRRGDLDGAEPLLRGATAEGDRAAANNLGVLLHQRGYAEEAAGWWKVAAVAGSAAAAHALGRHHRERGDEPAAEYWLRQSAEQGHALGAYALADLLEHRREEGAERWMRAAAERGHREAAHRLARILDERGRTSEDAAHEAEQWYRQAAARGHRRAALRLGTILEGRGKLKEAGRWYLTSAKEGEPEAACALGFLLRDAGDEENAALWWLKAAKEGDGNAANALGALHAERGETQTAERWYRAALEAGDVNGAYNLGLLCAAQNRTAQADQWYRRAAYAGHREAANALAVLLLQENDADGAEPWFSKAAELGSVDAAFNLGILHAGRGDQRGAQRWYERAAAAGHTEAAFQAGIALLRDGDERGAERHLRCAAGGGSADGAYYLASLLDARTPPGEQPALGEPVLERTESEEWYERAAHLGHRRAQVRIGMIAATRGDVVSAARWYRAAAEAGSRNGAFNLGLLLAREGSEPEAAVWWEQAADAGHGRAALRLALLHARRGELAESDRWCGRAVELGPAEVAARAGRLRDQLQQELTA
>NZ_CP016824.1|WP_107436696.1|5003522_5006519_+|UPF0182-family-protein
MPDRGGGPTGPRIRVGRPSRRSRTLLMTLGVLAVLAMLFVMFAGFWTDWLWYKAVDYSSVFTTTLWTKIGLFFVFGLLMALAGGVNIWLAHRLRPPLSAMSLEQQSLDRYRMSIAPYKKWMLIGVTAVIGLISGASAAGQWRTWLLWINGVPFGEKDPQFGKDVAFYAFDLPWYRFLLGFGFAAAVLSLIAAALVHYLYGGLRVTSPGARATGAATGHLSVLLGLFVALKAVAYWLDRYGLAVKSSDFKAAGNWTGLRYVDANAYLPAKTILFCIAVICALLFFATLWRRTWQLPVIGFGLMVLSAILIGGLYPAIVQKFQVDPNEQAKEAPYVSQNLKATKKAYGIDDAKVTEYSGKAQTEDRTELRGEVAKAASIRLLDPNIVSPTFQQLQQMKGYYAFPQNLDVDRYKDADGNSRDTVIGLRELNLNGIPKNNWINDHFRYTHGFGVVAAEGTTADSEGRPVFTESDLPSKGDLVKGKYEQRIYYGERTEQYSIVGGPQKEIDYSDDNGEKTTSFSGKGGVDLSNPVNRAAYAVAFGEPQILYSGAIGEGSQVLYNRTPKDRVEAVAPWLTIDGDAYPAVVDGKIQWIVDAYTTSNGYPYSSRTTLGDTTADSLTAENQQRAVVAQENQVNYIRNSVKATVDAYDGTVKLYEWDTKDPVLKTWMKSFPGTVEPRGEISDELMDHLRYPQDLFKVQRELLTRYHVDNANTFLSGSQVWQVPDDPTNKSGESVPAYYLSMRMPDQEKQAFSLTTTFTPNNRDNLSAFMAVNAEADADDYGKIRVLKLPASTTVSGPKQVQSQFNSEQDIAESIRLLRGGDSEVEYGNLLTVPLDGGLLYVEPVYVRGGGLKYPLLRKVLVTYGGATAFEDTLGEALDKIFGTEGAEQPPGEQPEKPTDPPTGGNAVEDALKDAQKAYDEGQTALKEGDWEAYGKAQAELEKALEAMEKAAAEGGDGKNADKDPAESAGSEDARKEEQDGNGDKEAGKKPAEQAADRS
>NZ_CP016824.1|WP_067415558.1|5002781_5003342_-|hypothetical-protein
MSTHSPSGPPMAGPPLTRAVLEIDEYVAGLGWDRPALLFALVDTARLRSEEPGLADRLGIGEDVPDAAPLTPVEQEEIPAGKPPDEFLATIAWPDAVAGCVLAVERLMLPPSAEAQVPDGLDDAALAKWVAAHPDRQEVRMTVGVLRDGTRDSALRLREKDASTEVLTGADLVPGLAEALAATFAE
>NZ_CP016824.1|WP_067415555.1|5001586_5002687_+|PDZ-domain-containing-protein
MPRRTATMLTSTLLLIALLCAGVLIKVPYAEMTPGPTVNTLGDHDGEPVLNIKGHKTYPTDGHLNMTTVRVTSPDYRMNLFQAVAGWIAHDNVVVPHETLYPDGKTEEQSTQENAEEFSQSQESAKVAALRELDIPVSTRVVVATVVKGNPAEGKLHAGDVIKSVDGSPVRKPGDVAELVTKHQPDEPVVFTIVPAADAAAAEKAGEEPSGTERVTVTTAPAGKSGGEAKRAIVGIQAGTDHTFPFTVDIKLADVGGPSAGLMFALGIVDKLSPDDLTGGKFIAGTGTIDEDGAVGPIGGISMKTVGARAKGAQYFLTPADNCATAAKDVPDGLTLVKVDTIDDALDSLEKIREDRTEALPACTTG
>NZ_CP016824.1|WP_008415685.1|5001303_5001561_+|hypothetical-protein
MAALAWLLIPLMAAIGAALWGSWAARNPGRNDGPELAGYARFRAAMAKSHGDPDAAESALPADLPATGEREQAHQPSDGPAPAVR
>NZ_CP016824.1|WP_003950742.1|5000633_5001116_+|molybdenum-cofactor-biosynthesis-protein-MoaE
MASTHTAHPERPDHPGERAAEDPIALLAVRDTPLSLDEVFKAVGEDAAGGTALFVGTVRNHDGGADVARLGYSAHPTAEAELRRVAERVVAAHPVRALAAVHRTGDLRVGEIAVIVAVSCPHRAEAFEACRMLIDDLKHEVPLWKHQTFDDGTEEWVGAC
>NZ_CP016824.1|WP_079165381.1|4999344_5000526_+|SDR-family-oxidoreductase
MTETSGPADPLPGGRKQPAGGFEAADTPEPAAERPARPVRGPVVAVTGAAGGVGALLTERLAASEEIKRVIAIDERRGECEGAEWQILDVRDPALAEKLRGVDVVVHLALDLDLESDPAARTAFNVRGTQTVLTAAPAAGVHRVVLCTSAMVYGALPDNELPLSEDAELRATAEATGVGDLLEIERLAKRAPRTHPGLNVTVVRPAVLVGGGADTALTRYFESPRLLVVADSRPAWQFCHVEDLCAALEYAVLERVEGDLAVGCDGWLEQEQVEELSGIRRMELPSAVALGAAARLHRIGLTPSAAGDLAYTMYPWVVSGSRLHHAGWRPKWTNEEVLGELLEEVAGRHTVAGRRLGRKDATVAGAAGAAGATVALLGTAAIVRRARKARRRI
>NZ_CP016824.1|WP_030306203.1|4997578_4999060_-|zinc-dependent-metalloprotease
MSDTPFGFGLPPEEPDDGDEGKKKDNQGGGAGQGANPLGFGMPGMPGIGPGGGDNPFAAMFGSLNPADLGAAFQQLGQMLSYEGGPVNWDMAKQIARQTVAQGTADGTKDASVGAAERHAVDEAVRLADHWLDGVTALPSGASTSVAWSRAEWVEATLPVWQELVDPVAERVGAAMGDVLPEEMKSMAGPLLGMMRSMGGAMFGTQMGQAVGTLAGEVVGSTDVGLPLGPAGKAALLPLNIEALGKDLGVPLEEVRLYLALREAAHQRLFAHVPWLRSHLFGAVEGYARGIDVDTAKLEDAVSQLDPSNPEQLQEALQQGMFQPEDTPQQKAALARLETALALVEGWVDAVVHEAAKPRLASADALRETLRRRRASGGPAEQTFATLIGLELRPRRLRDASRLWASLADARGADGRDALWEHPDMLPTAHDLDDPDGFVHREHADFSELDKLLGEAAGGPSLSKDRPEDAEEPGKKDKGSDDGDGQEGGEGSR
>NZ_CP016824.1|WP_031177207.1|4997048_4997582_-|NUDIX-hydrolase
MTLHDDAVLVLKEYEDQPGLRQQYLDHLAAHPDGMYKLCEAGHLTASALVLDPSRGQVLLTLHRKLNMWLQMGGHCEPEDTSVARAALREATEESGIPGLELLPGGPVRLDRHAIPAPCNWHLDIQYAALAPAGAAAAISDESLDLRWFAYDEVAGVADASVVRLLEAARKRLGAPG
>NZ_CP016824.1|WP_010642433.1|4996232_4996985_+|AIM24-family-protein
MQSPLFAFTEQQSQDRYTLQNAQMLRVTLTGHDDILARKGAMVAYQGLVEFDGEYQSHQQQQARAWTGEGLDLMRCSGQGSVYFANLAQYVHVLDVEQDGLTVDSSYVLAMDSSLHAEVLAVDSQFGISGSGKYQLNITGRGKIALMTSGPPLMLQVTPEKYVNADADAIVAWSTSLRVQMQAQTHSSGVWRRRGSTGEGWELSFLGSGFALVQPSELLPPQNAATGGLAGQFGMGQQGARGQNQGNVWS
>NZ_CP016824.1|WP_067415563.1|5009272_5009689_-|transcriptional-repressor
MSDLLERLRGRGWRMTAQRRVVAEVLNGDHVHLTADEVHAKAIAKLPEISRATVYNTLGEMVTLGEVIEVATDGRAKRYDPNAHRPHHHLVCARCGTIRDVHPTGNPLADLPDQERFGFTVSEVEVTYRGLCPHCAAA
>NZ_CP016824.1|WP_067415566.1|5009836_5011288_+|catalase
MTQGPLTTEAGAPVADNQNSETAGVGGPVLVQDQLLLEKLAHFNRERIPERVVHARGAGAYGTFTVTADVTQWTRASFLSEVGKQTETFLRFSTVAGNLGAADAVRDPRGFALKFYTEDGNYDLVGNNTPVFFIKDAIKFPDFIHTQKRDPYTGSQEADNVWDFWGLSPESTHQVTWLFGDRGIPASYRHMNGYGSHTYQWNNEAGEVFWVKYHFKTDQGIKNLTTSEAAETSGLDPDSHQRDLREAIERGDFPSWTVQVQIMPAADAATYRFNPFDLTKVWPHEDYPPIEIGKLELNRNPENIFAEVEQSIFSPAHFVPGIGPSPDKMLQGRLFSYGDAHRYRVGINADHLPVNRPHATEARTNSRDGYLYDGRHKGAKNYEPNSFGGPAETGRALWQPLPVTGETGDTEAPSHAEDDNFVQAGHLYRLMSEDEKTRLVENLSQNIAGVSRDDIAERAINNFRQADADFGKRLEAAVQALRG
>NZ_CP016824.1|WP_067415569.1|5011368_5012175_-|histidinol-phosphatase
MADYHDDLRLAHVLADAADATTMERFKALDLKVETKPDLTPVTEADKAAEELIRGHLARARPRDAILGEEYGVEGTGPRRWVIDPIDGTKNYVRGGPVWATLISLMEADPQGGGFRPVVGLVSAPALGRRWGAAKGAGAYTGRSLTSASRLKVSAVDRVENASFAYSSLSGWEAQGRLDGFLDLTRTCWRTRGYGDFWPYMMVAEGSVDICAEPELSLWDMAANAVIVEEAGGTFTSLEGAPGPSGENAAASNGLLHDELLGYLNQRY
>NZ_CP016824.1|WP_067415572.1|5012318_5012936_+|TetR/AcrR-family-transcriptional-regulator
MSEVRAALLIAAEAHLARRPWSAVRMGEVAASAGVSRQTLYNEFGSKEGLARALARQAADGYLAGIERALARSAADSRERLRAAADWTVAAARPGTLLRSLLTGCWGDPLPAPRPARTTATAPAQRRAELPLPGPGDLLAAARDRAVAALDGAAPRTDPRELARECECVLRLALSRVVAPPVVGGGGAGRRRGRVTGPSPRAGGR
>NZ_CP016824.1|WP_003950752.1|5012901_5013225_-|multidrug-efflux-SMR-transporter
MAWLLVVVAGLLETGFAVCLKLSHGFTRLWPTIAFAAFALGSFGLLTLALKRLDVGPAYAVWTGIGAAGTATYGMIFLGDVVSVLKIVSITLVICGVIGLQLSGSAQ
>NZ_CP016824.1|WP_067415575.1|5013352_5014369_-|ribosome-small-subunit-dependent-GTPase-A
MRRYGKNPDEDDIRVRPSRRGSRPRTHTRPKHEDAAEGMVLTVDRGRITCLVEGRTVTAMKARELGRKAAVVGDRVALVGDLSGQKDTLARIVRIEERASVLRRTADDDDPYERVVVANADRLAIVTALADPEPRPRMIDRCLVAAYDGGLEPVLVLTKSDLASPDSLLDTYRALGVPYVVTSREELEDGSAVERVRELLDGHVTAFVGHSGVGKTTLVNALVPEEQRRVTGHVNAVTGRGRHTTVSALALPLADAAPRSWVIDTPGVRSFGLHHVDPSRVIHAFPDLERGTEECPRGCSHDEPECALDQWVADGHADPARLNSLRRLLATRERREGD
>NZ_CP016824.1|WP_067415578.1|5014386_5015739_-|3-phosphoshikimate-1-carboxyvinyltransferase
MTLNPVSTPLWPAPYATGAVEATVQVPGSKSVTNRALVLAALAAEPGWLRRPLRSRDTVLMAEALRTLGVGIEETVSSDSAAPGSTLAKGGEAWRIIPSGLRGPATVDVGNAGTVMRFLPPLATLADGDIRFDGDPRSYERPLHGVIDALRALGARIDDDDRGSLPMTVHGTGSLDGGTVEIDASSSSQFVSALLLSAPRFNQGVEVRHIGPRLPSMPHIRMTVDMLRRVGAQVDEPESGGEPNVWRVTPGALLGRDLTVEPDLSNAQPFLAAALVTGGRVVIPDWPAHTTQPGDRLREIFTTMGGSCELTEAGLVFTGSGRVHGIDVDLGEVGELTPGIAAVAALADGESVLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLRIRPRPLHGGVFHTYDDHRMATAGAILGLVVKGVEIENVATTAKTLPDFPDLWTGMLDGTGQ
>NZ_CP016824.1|WP_003950755.1|5015781_5016504_-|M50-family-metallopeptidase
MQSTTAAPATDLWDRVTGTQTAPEFWLVVATGVAALAVVLWGPAWRTARNAITIAHEGGHGLIALVTGRTLEGIRLHSDTSGLTVSRGRPTGPGMILTALAGYTAPSLLGLGGAWLLASGHITLLLWVATALLLALLVMVRNAYGVLTVLITGGLFVAVSWLAGSEVQALFAYAAVWFLLLGGVRPVFELQSKRRRGGAPDSDADQLARLTHAPAAIWLFLFHAVALCSLIGGGGWLLGR
>NZ_CP016824.1|WP_067415581.1|5016593_5017466_+|SOS-response-associated-peptidase
MCGRYAATRSPEDLSEIFGVEKTELSEAAEGQEDGHEAGASPVPTETLVPDWNVAPTKEVPAILDRPVKGSDDPRPVRQLRMLTWGLVPSWATSPDGGARMINARAETVHEKPAYRRAFASRRCILPADGYYEWVTAPEERKLEEEGKRKRARKQPYFVTPADGSVFAMAGLYEFWRDPSLRGDHPRAWWVTCSVLTTEAETAPLGVGPEEGPRALADIHPRMPLMLTPDKWDAWLDPSKTDVGEVRELLGAPPEGLMRAYPVATAVSNVRNNGPGLVSELDGPEVGTLF
>NZ_CP016824.1|WP_067415584.1|5017742_5018390_+|hydrolase
MPAAGERVSVATDVGEARVTWVRAEVPRVVLALGHGAGGGIEARDLVALAGVWPGAGVSVALVEQPWRVAGKKVAPAPKTLDKGWEAVWGEVAGEGLPVVAGGRSAGARVACRTGAELGAAGVLALSFPLHPPGKPERSRAGELLGTGVPTLVVQGGRDPFGRPEEFPGGSYELAEVAYGDHGFAVPKKAPVGQEEALRVITDAVGAWIERLPVG

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Crispr_ID: NZ_CP016824_31

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_31

5175188-5175338

Orphan

Consensus_repeat	Method
CAGCCCGGCCGGCGCTTGAGGCCATCTTTGACCGGGAGGT	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP016824_31

>merge|NZ_CP016824|31|5175188-5175338|PILER-CR
TGGCCTCAAGCGCCGGCCGGGCTGATCGAGGGGTGCTGGTCGGTGCCGACCTCGCGGTCAAGGATGGCCTCAAGCGCCGGCCGGGCTGGGTTTGTGCGCCGGTCCGATGCGACCTGCCGGTCAAAGATGGCCTCAAGCGCCGGCCGGGCTG

>NZ_CP016824|31|5|5175188-5175338|PILER-CR
TGGCCTCAAGCGCCGGCCGGGCTGATCGAGGGGTGCTGGT	CGGTGCCGACCTCGCGGTCAAGGA
TGGCCTCAAGCGCCGGCCGGGCTGGGTTTGTGCGCCGGTC	CGATGCGACCTGCCGGTCAAAGA
TGGCCTCAAGCGCCGGCCGGGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067415722.1\|5165563_5166412_+\|3-hydroxyacyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|224170
NZ_CP016824.1\|WP_003950904.1\|5177362_5178301_-\|cellulose-binding-protein	unknown	unknown	gnl\|CDD\|224117
NZ_CP016824.1\|WP_003950899.1\|5172789_5173131_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_010642197.1\|5188077_5189505_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|273593
NZ_CP016824.1\|WP_086014554.1\|5170134_5170836_-\|endonuclease-NucS	unknown	unknown	gnl\|CDD\|235114
NZ_CP016824.1\|WP_008407901.1\|5187415_5188081_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP016824.1\|WP_030765280.1\|5185613_5186459_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225596
NZ_CP016824.1\|WP_003950893.1\|5166819_5167143_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP016824.1\|WP_067415724.1\|5167465_5169883_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223021
NZ_CP016824.1\|WP_003950906.1\|5182633_5183074_-\|methylmalonyl-CoA-epimerase	unknown	unknown	gnl\|CDD\|213772
NZ_CP016824.1\|WP_003950896.1\|5171009_5171402_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_010642212.1\|5175446_5176217_-\|ABC-transporter-permease-subunit	unknown	unknown	unknown
NZ_CP016824.1\|WP_067415726.1\|5171496_5172531_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NZ_CP016824.1\|WP_003950891.1\|5164810_5165383_-\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	unknown	unknown	gnl\|CDD\|376665
NZ_CP016824.1\|WP_067415727.1\|5176218_5177238_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP016824.1\|WP_067415732.1\|5184508_5185498_+\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl\|CDD\|224617
NZ_CP016824.1\|WP_008409337.1\|5173149_5173986_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|372253
NZ_CP016824.1\|WP_067415729.1\|5178560_5182424_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173412
NZ_CP016824.1\|WP_008409338.1\|5173982_5175065_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP016824.1\|WP_003950907.1\|5183217_5184420_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|180261

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067415722.1\|5165563_5166412_+\|3-hydroxyacyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|224170	COG1250, FadB, 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism].	2.28038e-124
NZ_CP016824.1\|WP_067415732.1\|5184508_5185498_+\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl\|CDD\|224617	COG1703, ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism].	1.06494e-120
NZ_CP016824.1\|WP_010642197.1\|5188077_5189505_+\|HAMP-domain-containing-protein	gnl\|CDD\|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	3.60855e-48
NZ_CP016824.1\|WP_086014554.1\|5170134_5170836_-\|endonuclease-NucS	gnl\|CDD\|235114	PRK03298, PRK03298, endonuclease NucS.	1.188e-176
NZ_CP016824.1\|WP_008407901.1\|5187415_5188081_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.92636e-85
NZ_CP016824.1\|WP_030765280.1\|5185613_5186459_-\|hypothetical-protein	gnl\|CDD\|225596	COG3054, COG3054, Predicted transcriptional regulator [General function prediction only].	0.00787616
NZ_CP016824.1\|WP_003950893.1\|5166819_5167143_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	3.80542e-20
NZ_CP016824.1\|WP_067415724.1\|5167465_5169883_+\|ATP-binding-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	4.59857e-06
NZ_CP016824.1\|WP_003950906.1\|5182633_5183074_-\|methylmalonyl-CoA-epimerase	gnl\|CDD\|213772	TIGR03081, Methylmalonyl-CoA_epimerase_mitochondrial, methylmalonyl-CoA epimerase. Members of this protein family are the enzyme methylmalonyl-CoA epimerase (EC 5.1.99.1), also called methylmalonyl-CoA racemase. This enzyme converts (2R)-methylmalonyl-CoA to (2S)-methylmalonyl-CoA, which is then a substrate for methylmalonyl-CoA mutase (TIGR00642). It is known in bacteria, archaea, and as a mitochondrial protein in animals. It is closely related to lactoylglutathione lyase (TIGR00068), which is also called glyoxylase I, and is also a homodimer.	7.337e-51
NZ_CP016824.1\|WP_003950904.1\|5177362_5178301_-\|cellulose-binding-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	1.2649e-06
NZ_CP016824.1\|WP_067415726.1\|5171496_5172531_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	1.30567e-48
NZ_CP016824.1\|WP_003950891.1\|5164810_5165383_-\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	gnl\|CDD\|376665	pfam01923, Cob_adeno_trans, Cobalamin adenosyltransferase. Cobalamin adenosyltransferase This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation.The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12.	4.10908e-79
NZ_CP016824.1\|WP_067415727.1\|5176218_5177238_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.31275e-89
NZ_CP016824.1\|WP_008409337.1\|5173149_5173986_-\|ABC-transporter-permease-subunit	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	2.32431e-05
NZ_CP016824.1\|WP_067415729.1\|5178560_5182424_-\|hypothetical-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	1.49522e-22
NZ_CP016824.1\|WP_008409338.1\|5173982_5175065_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.17964e-91
NZ_CP016824.1\|WP_003950907.1\|5183217_5184420_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0

>NZ_CP016824.1|WP_008409338.1|5173982_5175065_-|ABC-transporter-ATP-binding-protein
MIEATGLTKRYGAKTAVHDLSFQVRPGTVTGFLGPNGSGKSTTMRMIVGLDEPTSGHVTIGGLPYRRVPNAPRQVGALLDAKAVHGGRSARNHLLCLAQLSGIPARRVDEVLGVVGLQDVARHRSKGFSLGMGQRLGIAAALLGDPQVLLFDEPVNGLDPEGILWVRTLMKSLAAEGRTVFVSSHLMSEMALTAEHLIVIGRGRLMADMSVREFIAANAAGFARVRVPDTEPGSREKLAAALAEEGGQVLPEPDGALRVAGLPLPRISDVAHTAGVRLWELSPHQASLEEAYMRLTQGAVDYRSTDDRRAGLHEEGAQGPEPFPVPQPGADQPGWYAPPPPRQERPAAPDLSKSDTEDPR
>NZ_CP016824.1|WP_008409337.1|5173149_5173986_-|ABC-transporter-permease-subunit
MTTPTQQPEQPGALPGAMYTSPIPVRPTHLGHALASEWTKIRSVRSTVWTLCVFVALVVGIGLLVGWKTSGETYTDVPYTIPALFGLMLGQICLITLGVLVVTSEYGTGMIRTTFTAAPQRHRVLAAKFLVFFALAYTVSAVSITVVGLATAAINEIPSGPGENWGTSVLLGSLYVSLLGVLGLAVGSMLRHSAGAITAMLGVVLVPAIMPAFLMISPALRGIGETMLEYNAPNSLSALFGTAMYDGQAGGVPQLLALLGITLVAVAGAFALLEKRDV
>NZ_CP016824.1|WP_003950899.1|5172789_5173131_+|hypothetical-protein
MSPRKNRSKPSRSSGRRGGGDDEPGERYGFQSAESWRGEQWSVRHISGSGPASAGKRYRCPGCDQEIPAGLPHVVAWPEHSGVDERRHWHKACWNAKDRRTTRVQRSRNAPRF
>NZ_CP016824.1|WP_067415726.1|5171496_5172531_-|LLM-class-flavin-dependent-oxidoreductase
MHVGSFVLGGQFPGQGQGEALHRAVRSAEVAEEAGLDTVWLGEHHFVPYGTCPSAATLAALLLGRTRRVRVGTAVSVLPTTHPVALGEQAALLHLAADGRFTLGVGRGGPWVDLEVFGAGLPAFEEGFPEALDLLLRWLREPRVGASAEGGRYAFREVAVVPSPAESLDGLPGPEVVVACTSPSSVRLAAERGLPMLLGMHTGDAEKAEMVALWRRHAREAGRDGDEIAAAAHVSAGVAQVEDGPGRATETLVKAMPGWFELGLGAHVTVDGRARAMRDPVAYTEFLCSIHPVGPPRLCADRLAATAEATGITRFALMVEGSGDLAGTEENIRRLGRDVLPLLR
>NZ_CP016824.1|WP_003950896.1|5171009_5171402_+|hypothetical-protein
MSLDVSPALLEQAERGEVDEAAFVDCVRTSLPYAWDMISKLVAQLKVDGGEFADNQTPPPDEQARGQLLRALASDAIRGALQRHFGVRLAFQNCHRVAVFPLSSDSDERHARFTSIRGQLLNQSPELRDC
>NZ_CP016824.1|WP_086014554.1|5170134_5170836_-|endonuclease-NucS
MASGAARRVALPTMRLVIARCSVDYAGRLTAHLPSAPRLILVKADGSVSIHADDRAYKPLNWMSPPCTLKEGEDNVWTVVNKGGEKLVITMEEVLHDSSHELGVDPGLIKDGVEAHLQELLADRIETLGEGYTLIRREYPTAIGPVDILCRDASGATVAVEIKRRGEIDGVEQLTRYLELLNRDPHLAPVRGVFAAQEIKPQARVLATDRGIGCTVLDYNALRGIEDDKLRLF
>NZ_CP016824.1|WP_067415724.1|5167465_5169883_+|ATP-binding-protein
MDPNHRDPHQRGDGDPHRIPGGPQPGAVERRPRPPQGPDLGQPVPPRVRTAELVAGGHLVTVNPVDGSEIEVCPPGRHPSPPVRRTPDDRAALAAAARPPAPPGVPRTHHRLLERDRERDTLVQLLARGRSVRLTGSRGSGRTVLLDAVAARCEGLAPDGVVRLDGHHRTADELLHALCAAVHLLPAHRPGPALLAELAGEIGAVVLIDDAEIGGAALDSFLAATPECAVLLACTPEVPAPGEEARVEEVVLDGIGRSGGLTLLAQGAGRALSDDEVSWAGDLWFESEGLPLRFVQAGALLHQRDLLREESGSAEAPLPTVAEGAAPAALLASRLSEAARATLGFAYALGGEVPHQAHLPALVGDTHADAALTELLDCGLVTPVGNRYRLAAGVTEQLAAEGYADEGERAHTAAQHYTWWTGHPSVTPERAAAESDAVLAALTALVGGQDPARQATAVLLARTVAPVLAAGLAWGAWERVLRSGQEAARLSGEVAEEAYFHHELGILALCQDRLDRARAELEAAVALRGALADKRGTVAGRRALALVADRAGETVPVTRAVLPTDGPPVLPRRDGLGTPPTGFPRTTPAAGVTRVQPAASATGATVVGGPAATAAKDGRPGRAAVTGARRNLVAAGAGALLVAVLGTVVTLGAINGDDEEPASVDRVTTEQTTPEDEGDEGTEAERPADSAEPSTDPGEDGVTGTPDDPTPGDSGSPSESESDEPSSSPTDRPTTSPSDRPTTKPPTTPPTSSKPPTTPPPSSPDPEPSDTTPPTEDPDPEDPEPGTDNSASGPAPEPSTSQTLS
>NZ_CP016824.1|WP_003950893.1|5166819_5167143_+|STAS-domain-containing-protein
MYIRGDHAELVVGGRLDVRSAADARTVLHSAVDDGAGDLVLDLAALDSWDATGLGVIMGAHRRAGRCGRRLVLRSVPPQMQRLLVATRLHRILAIEGGIGLDSLPRA
>NZ_CP016824.1|WP_067415722.1|5165563_5166412_+|3-hydroxyacyl-CoA-dehydrogenase-family-protein
MARKLAVIGAGLMGSGIAQVSAQAGWDVVLRDVTDAALTRGTDGIKSSFDRFVAKGKLSAEDAGAALGRITTTTDLEGAADADIVVEAVFEQLDVKHEIFRTLDKLVREDTVLASNTSAIPITKIAAVTERPERVVGAHFFSPVPMMQLCELVRGYKTSDETLARTGEFAESTGKTCIVVNRDVAGFVTTRLISALVVEAAKLYESGVATAEDIDLACKLGFGHAMGPLTTADLTGVDILLHATQNIYTESQDEKFAPPELMRRMVDAGDLGRKSGEGFYSY
>NZ_CP016824.1|WP_003950891.1|5164810_5165383_-|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase
MVNLTRIYTRTGDKGTTALGDMSRTAKTDPRIAAYADANEANAAIGTALALGDLPEDIAKVLLRVQNDLFDVGADLSTPVVENPEYPPLRVEQSYIDKLEADCDTYLEQVEKLRSFILPGGTPGAALLHQACTVVRRAERSTWAAAEVFGDTMNPLAATYLNRLSDLLFILARVANKEVGDVLWVPGGER
>NZ_CP016824.1|WP_010642212.1|5175446_5176217_-|ABC-transporter-permease-subunit
MAVTQVVRSEWTKIRSVQSTVWTLGLAAVVTIGLGALISALSKSEYENLSPRDQLTFDPTFISFAGLSLGQLAMVVFGVLVVSNEYSTGMIRMSLAAVPQRGTFFFSKVAVATVLALLVSLVTTFATFFLGQALLGNLSASIGDPGVLRAVIGAALYMTLMAVFSMGVAAMLRSPMLSLGILVPFFFLVSSILGAVSATEKIGRFLPDQAGSKIMQVVAPLNDDTPYGPWGGLGIMALWVIAALAIGYALLRHRDA
>NZ_CP016824.1|WP_067415727.1|5176218_5177238_-|ATP-binding-cassette-domain-containing-protein
MIELSGLTKRYGERVAVNNLTFTVRPGIVTGFLGPNGAGKSTTMRMILGLDRPSAGDVRIDGRHYAQLHDPLRQIGALLDAKAMHGGRTAYNHLLCLAQSNGIPASRVTEVLDTVGLTPVARKRAKGFSLGMGQRLGIAGALLGDPRILMFDEPVNGLDPEGIHWIRNLMKSLAHQGRTVFVSSHLMSEMALTAEHLVVIGQGRLMADTSMADFIRENSRSYVTMRSPERERLLDVLHAAGIAVADGPDGAVEVDGVAAPELGELAARERLVLHELSPRQASLEEAFMQLTAESVEYHAHDGDPGAVRGGPGPGAGAASGGEGQWGAGWGGPEQRRRKG
>NZ_CP016824.1|WP_003950904.1|5177362_5178301_-|cellulose-binding-protein
MSDTSPYGFELVRRGYDRAQVDERISKLVSDRDSALTRITALEKRIEELHLETQNAQAQVADAEPSYAGLGARVEKILRLAEEEAKDLREEARRAAEQHRELAESAAQQVRNDAEAFATERKAKADDEGVRIVEKAKGEASALRAEAQKDAQSKREEADALFEETRAKAAQAAADFETNLAKRREQSERDLASRQAKAEKRLAEIEHRAEQLRLEAEKLRTDAERRARQTVETAQRQAEDIVADANAKADRIRSESERELAALTNRRDSINAQLTNVREMLATLTGAAVAAAGAPAAEDDSASRGVPAQQSR
>NZ_CP016824.1|WP_067415729.1|5178560_5182424_-|hypothetical-protein
MRGYEGQERHRADDHLSRFEAEMDRLKTDREKAVQHAEDLGYQVEVLRAKLHEARRALATRPHSYDTADLGYQAEQMLRNAQLQADQMRSDAERELREVRAQTQRILQEHAEQQARLQAELHTEAVNRRQQLDQELAERRATVESHVNENVAWAEQLRARSESQAQRLLDESRAQAEQSLAAARAEAQRLTEEARRRLGEETENARTEAEALLRRARADAERMLNAASQQAQEATDHAEQLRTSTASEADQAHRRSAELTRAAEQRMSEADTALREATSRSEKLVAEAEATAAKRMAAAEAAGEQRTRTAREQVARLVEEATKEAEAVRAEAEELRERAVAEAEKARSEAAEKARAAAAEDSAAALAKAARTAEEVLQKASKDAEETRRSASEEAERLRSEAEAEADRLRAEAHDLAEELKGAAKDDTKEYRAKTVELQEEARRLRGEAEQLRAEAVAEGERIRSEARREAVQQIEESATTAEELLTKAREDAAEAREAGEADGERTRAESAERAAALRKQADDALERARTEAAKLGEEAEEAAARTREEAEQAARELREETEEGVRARREEAETELVRLREEAEQRVVAAEEALTEARAEAGRLRKEAAEEAERTRTEAAERARTLSDQAVEEAEALTATAAEEAAASRAEGEAVAVRLRADAAEEAERLKAEAQEAADRLRAEAASAAERTEAEATEALERAQEEADRRRRSAEEALESARTEAGQERERAREQSEELLASARKRVEEAEAEAARLVEEADARATELVSAAEATAQQVRDSVAGLQEQAQEEIAGLRSAAEHAAERTRGEAQEEADRVRSDAHAERERASEDAARLRSEAAEELETARALAETAVSEATAESERLRADAGSYAQRLRSEASDALASAEADASKARAEARQDANRMRTEAAEQADRLVSQAATEAESLGARSAEEAERLRAEARAEAERTVTEAAEEAERLRAEAARAVAEAEERAARAREEAERVESQALAAAEELTSQARAEADRTLDEARADANKRRSEAAEQVDRLLSETAAEAEKLTTEAQQAALKATTEAESRADSMVGAARAEAERLVAEAAVEGNSLVERARADADELLVGARRDATAIRERAEELRERVTTEIEELHDRARRESSEAMRNAGERCDALVKAAEEQEAKARADAKELLADASSEAGKVRIAAVRKAEGLLKEAEQKKAELVREAEQIKREAEEEAERVVAEGQRELEVLMRRRADINQEISRVQDVLEALEGFESQPAGKAAPGGSGTGVKAGASAGSSRSGGKQNDN
>NZ_CP016824.1|WP_003950906.1|5182633_5183074_-|methylmalonyl-CoA-epimerase
MLTRIDHIGIACHDLDATVEFYRSTYGFEVFHTEVNEEQGVREAMLKINETSDGGASYLQLLEPTREDSAVGKWLAKNGEGVHHIAFGTADVDQDAADIRDKGVRVLYDEPRKGSMGSRITFLHPKDCHGVLTELVTSAPEESAEH
>NZ_CP016824.1|WP_003950907.1|5183217_5184420_+|acetyl-CoA-C-acetyltransferase
MTGTQSTTSVIVAGARTPMGRLLGSLKSFSGADLGSFAIKAALDRAGIGGDQVQYVIMGQVLTAGAGQIPARQAAVKAGIPMNVPALTINKVCLSGLDAIALADQLIRAGEFDVVVAGGQESMTNAPHLLPKSREGYKYGAVEMLDAMAHDGLTDSFENIAMGESTEKHNTRLGIARPEQDEIAALSHQRAAAAQKNGVFEAEITPVEIPQRKGDPVLFAKDEGIRAETTAESLGKLRPAFAKDGTITAGSSSQISDGAAAVVVMSKAKAEELGLEWIAEIGAHGNVSGPDNSLQSQPSNAIAHALKKDGLAVGDLDVIEINEAFAAVAVQSMKDLGVTSEKVNVNGGAIALGHPIGMSGARLVLHLALELKRRGGGIGAAALCGGGGQGDALIVRVPKS
>NZ_CP016824.1|WP_067415732.1|5184508_5185498_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MQDVPALVAQAREGRPRAVARLISLVEGASPQLRDVMAALAPLTGNAYVVGLTGSPGVGKSTTTSALVSAYRAAGKRVAVLAVDPSSPFSGGALLGDRIRMSDHASDPGVYIRSMATRGHLGGLAWAAPQAIRVLDAAGFDLVLVETVGVGQSEVEIAAQADTSVVLLAPGMGDGIQAAKAGILEIGDLYVVNKADRDGADATARELNHMLGLGEARSAGDWRPPIVKTVAAKGVGVDDLVDALEKHGGWMEERGVLAERRVARAAREVETIAVTALRSRIADLSGDARTGALAAQVVGGELSPYAAADVLLDAIAPRALGAPEESAGG
>NZ_CP016824.1|WP_030765280.1|5185613_5186459_-|hypothetical-protein
MTTHRPRPASRPHRSSRALATALAAGTLLATAACSGGQEAPAARESAAAPAHHLERGPSPSPSSRLTEEGARNALITEADIEEQWQKSQAPPQSWRDSLLLGEVDAAQFVTGRSDAKECQRLVDALYDDTLLGKPSGPTALAGFEQGDSRLLYQVAGYDKKTLDASMKWLASLPETCDTFTVTGGKGGRRTVEVTETSLPDEGDARQGLKVQLKGENEGTPLTLTLDVAAVRVGTDAFTVTNGGLDGADAPTTKNAVQHGTQRLEEVQAGHTPAPTPSEIE
>NZ_CP016824.1|WP_008407901.1|5187415_5188081_+|response-regulator-transcription-factor
MRLLIVEDEKRLALSLAKGLTAEGYAVDVVHDGLEGLHRASESPYDLLVLDIMLPGMNGYRVCAALRAAGNDVPILMLTAKDGEYDEAEGLDTGADDYLTKPFSYVVLVARVRALLRRRAGAGASPVHTVGGLRVDTAARRVQRDGEEVTLTAKEFAVLEQLVLRAGEVVSKADILEHVWDFAYDGDPNIVEVYISALRRKLGAQAIRTVRGMGYRLEAGR
>NZ_CP016824.1|WP_010642197.1|5188077_5189505_+|HAMP-domain-containing-protein
MKRLFGSVRAQATIGATLVVAVALIAAGTAVLLSLRSNLIQEAAAQADATARQVASKVAARTAYEDLDLPDDEDRPVQVVDSRGRLLAVSEDLERISGTGTDAVRPDPEALREPGGGNDDDDDGERLEAGEISDEVERGEGTATVDGHTADYRFSAVEVENDDDRLTVWAGAPLAAEQGAVSTAQTVMLIGLPLLLVVVAGVTWGVTGRALKPVEGIRREMAAITASEDLGRRVPEPSTHDEVARLARTTNATLTALEASVERQRSFVADASHELRSPIASLRTQLEVGLAHPELLDVAGAVEDTVRLQALAADLLLLARLDAGERPTGGRLDLGALVREEVSQRVGDRLPVTVHGRAGLEVAGSRGQLARVVGNLVDNAQRHAASRVEVRVRTDGPEAVVSVADDGSGVPEPERERIFERFVRLDDARSRDDGGAGLGLAIARDVAARHGGTLRVREAPEGGALFELRLPRPAD

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Crispr_ID: NZ_CP016824_33

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_33

5179812-5179985

Orphan

Consensus_repeat	Method
CGCCTCGGCCCGCAGCCGCTCCGCCTCCTCGGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP016824_33

>merge|NZ_CP016824|33|5179812-5179985|CRISPRCasFinder
GGCGTCCGCGCGCAGCCGCTCCGACTCGGCCGTCGCCTCCGAGACCGCCGTCTCGGCCAGCGCACGCGCCGTCTCCAGCTCCTCGGCCGCCTCCGACCGCAGCCGCGCCGCGTCCTCGGAGGCCCGCTCCCGCTCCGCGTGCGCGTCGGAACGGACCCGGTCCGCCTCCTCCTG

>NZ_CP016824|33|28|5179812-5179985|CRISPRCasFinder
GGCGTCCGCGCGCAGCCGCTCCGACTCGGCCGT	CGCCTCCGAGACCGCCGTCTCGGCCAGCGCACGCGCCGTCTCCAGCTCCTCGGC
CGCCTCCGACCGCAGCCGCGCCGCGTCCTCGGA	GGCCCGCTCCCGCTCCGCGTG
CGCGTCGGAACGGACCCGGTCCGCCTCCTCCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_010642197.1\|5188077_5189505_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|273593
NZ_CP016824.1\|WP_003950896.1\|5171009_5171402_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003950899.1\|5172789_5173131_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_018893529.1\|5190349_5190691_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|379642
NZ_CP016824.1\|WP_086014554.1\|5170134_5170836_-\|endonuclease-NucS	unknown	unknown	gnl\|CDD\|235114
NZ_CP016824.1\|WP_008407901.1\|5187415_5188081_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP016824.1\|WP_030765280.1\|5185613_5186459_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225596
NZ_CP016824.1\|WP_010642192.1\|5191340_5192054_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376704
NZ_CP016824.1\|WP_003950915.1\|5190747_5191224_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP016824.1\|WP_003950906.1\|5182633_5183074_-\|methylmalonyl-CoA-epimerase	unknown	unknown	gnl\|CDD\|213772
NZ_CP016824.1\|WP_067415724.1\|5167465_5169883_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223021
NZ_CP016824.1\|WP_003950904.1\|5177362_5178301_-\|cellulose-binding-protein	unknown	unknown	gnl\|CDD\|224117
NZ_CP016824.1\|WP_010642212.1\|5175446_5176217_-\|ABC-transporter-permease-subunit	unknown	unknown	unknown
NZ_CP016824.1\|WP_067415735.1\|5189510_5190353_-\|hydrolase	unknown	unknown	gnl\|CDD\|238494
NZ_CP016824.1\|WP_067415726.1\|5171496_5172531_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NZ_CP016824.1\|WP_067415727.1\|5176218_5177238_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP016824.1\|WP_067415732.1\|5184508_5185498_+\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl\|CDD\|224617
NZ_CP016824.1\|WP_008409337.1\|5173149_5173986_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|372253
NZ_CP016824.1\|WP_008409338.1\|5173982_5175065_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP016824.1\|WP_003950907.1\|5183217_5184420_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|180261

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_010642197.1\|5188077_5189505_+\|HAMP-domain-containing-protein	gnl\|CDD\|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	3.60855e-48
NZ_CP016824.1\|WP_067415732.1\|5184508_5185498_+\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl\|CDD\|224617	COG1703, ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism].	1.06494e-120
NZ_CP016824.1\|WP_018893529.1\|5190349_5190691_-\|N-acetyltransferase	gnl\|CDD\|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	1.80696e-26
NZ_CP016824.1\|WP_086014554.1\|5170134_5170836_-\|endonuclease-NucS	gnl\|CDD\|235114	PRK03298, PRK03298, endonuclease NucS.	1.188e-176
NZ_CP016824.1\|WP_008407901.1\|5187415_5188081_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.92636e-85
NZ_CP016824.1\|WP_003950915.1\|5190747_5191224_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.41125e-16
NZ_CP016824.1\|WP_010642192.1\|5191340_5192054_-\|hypothetical-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	1.25546e-10
NZ_CP016824.1\|WP_030765280.1\|5185613_5186459_-\|hypothetical-protein	gnl\|CDD\|225596	COG3054, COG3054, Predicted transcriptional regulator [General function prediction only].	0.00787616
NZ_CP016824.1\|WP_067415724.1\|5167465_5169883_+\|ATP-binding-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	4.59857e-06
NZ_CP016824.1\|WP_003950904.1\|5177362_5178301_-\|cellulose-binding-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	1.2649e-06
NZ_CP016824.1\|WP_067415735.1\|5189510_5190353_-\|hydrolase	gnl\|CDD\|238494	cd01012, YcaC_related, YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.	2.91417e-61
NZ_CP016824.1\|WP_067415726.1\|5171496_5172531_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	1.30567e-48
NZ_CP016824.1\|WP_067415727.1\|5176218_5177238_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.31275e-89
NZ_CP016824.1\|WP_008409337.1\|5173149_5173986_-\|ABC-transporter-permease-subunit	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	2.32431e-05
NZ_CP016824.1\|WP_003950906.1\|5182633_5183074_-\|methylmalonyl-CoA-epimerase	gnl\|CDD\|213772	TIGR03081, Methylmalonyl-CoA_epimerase_mitochondrial, methylmalonyl-CoA epimerase. Members of this protein family are the enzyme methylmalonyl-CoA epimerase (EC 5.1.99.1), also called methylmalonyl-CoA racemase. This enzyme converts (2R)-methylmalonyl-CoA to (2S)-methylmalonyl-CoA, which is then a substrate for methylmalonyl-CoA mutase (TIGR00642). It is known in bacteria, archaea, and as a mitochondrial protein in animals. It is closely related to lactoylglutathione lyase (TIGR00068), which is also called glyoxylase I, and is also a homodimer.	7.337e-51
NZ_CP016824.1\|WP_008409338.1\|5173982_5175065_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.17964e-91
NZ_CP016824.1\|WP_003950907.1\|5183217_5184420_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0

>NZ_CP016824.1|WP_003950904.1|5177362_5178301_-|cellulose-binding-protein
MSDTSPYGFELVRRGYDRAQVDERISKLVSDRDSALTRITALEKRIEELHLETQNAQAQVADAEPSYAGLGARVEKILRLAEEEAKDLREEARRAAEQHRELAESAAQQVRNDAEAFATERKAKADDEGVRIVEKAKGEASALRAEAQKDAQSKREEADALFEETRAKAAQAAADFETNLAKRREQSERDLASRQAKAEKRLAEIEHRAEQLRLEAEKLRTDAERRARQTVETAQRQAEDIVADANAKADRIRSESERELAALTNRRDSINAQLTNVREMLATLTGAAVAAAGAPAAEDDSASRGVPAQQSR
>NZ_CP016824.1|WP_067415727.1|5176218_5177238_-|ATP-binding-cassette-domain-containing-protein
MIELSGLTKRYGERVAVNNLTFTVRPGIVTGFLGPNGAGKSTTMRMILGLDRPSAGDVRIDGRHYAQLHDPLRQIGALLDAKAMHGGRTAYNHLLCLAQSNGIPASRVTEVLDTVGLTPVARKRAKGFSLGMGQRLGIAGALLGDPRILMFDEPVNGLDPEGIHWIRNLMKSLAHQGRTVFVSSHLMSEMALTAEHLVVIGQGRLMADTSMADFIRENSRSYVTMRSPERERLLDVLHAAGIAVADGPDGAVEVDGVAAPELGELAARERLVLHELSPRQASLEEAFMQLTAESVEYHAHDGDPGAVRGGPGPGAGAASGGEGQWGAGWGGPEQRRRKG
>NZ_CP016824.1|WP_010642212.1|5175446_5176217_-|ABC-transporter-permease-subunit
MAVTQVVRSEWTKIRSVQSTVWTLGLAAVVTIGLGALISALSKSEYENLSPRDQLTFDPTFISFAGLSLGQLAMVVFGVLVVSNEYSTGMIRMSLAAVPQRGTFFFSKVAVATVLALLVSLVTTFATFFLGQALLGNLSASIGDPGVLRAVIGAALYMTLMAVFSMGVAAMLRSPMLSLGILVPFFFLVSSILGAVSATEKIGRFLPDQAGSKIMQVVAPLNDDTPYGPWGGLGIMALWVIAALAIGYALLRHRDA
>NZ_CP016824.1|WP_008409338.1|5173982_5175065_-|ABC-transporter-ATP-binding-protein
MIEATGLTKRYGAKTAVHDLSFQVRPGTVTGFLGPNGSGKSTTMRMIVGLDEPTSGHVTIGGLPYRRVPNAPRQVGALLDAKAVHGGRSARNHLLCLAQLSGIPARRVDEVLGVVGLQDVARHRSKGFSLGMGQRLGIAAALLGDPQVLLFDEPVNGLDPEGILWVRTLMKSLAAEGRTVFVSSHLMSEMALTAEHLIVIGRGRLMADMSVREFIAANAAGFARVRVPDTEPGSREKLAAALAEEGGQVLPEPDGALRVAGLPLPRISDVAHTAGVRLWELSPHQASLEEAYMRLTQGAVDYRSTDDRRAGLHEEGAQGPEPFPVPQPGADQPGWYAPPPPRQERPAAPDLSKSDTEDPR
>NZ_CP016824.1|WP_008409337.1|5173149_5173986_-|ABC-transporter-permease-subunit
MTTPTQQPEQPGALPGAMYTSPIPVRPTHLGHALASEWTKIRSVRSTVWTLCVFVALVVGIGLLVGWKTSGETYTDVPYTIPALFGLMLGQICLITLGVLVVTSEYGTGMIRTTFTAAPQRHRVLAAKFLVFFALAYTVSAVSITVVGLATAAINEIPSGPGENWGTSVLLGSLYVSLLGVLGLAVGSMLRHSAGAITAMLGVVLVPAIMPAFLMISPALRGIGETMLEYNAPNSLSALFGTAMYDGQAGGVPQLLALLGITLVAVAGAFALLEKRDV
>NZ_CP016824.1|WP_003950899.1|5172789_5173131_+|hypothetical-protein
MSPRKNRSKPSRSSGRRGGGDDEPGERYGFQSAESWRGEQWSVRHISGSGPASAGKRYRCPGCDQEIPAGLPHVVAWPEHSGVDERRHWHKACWNAKDRRTTRVQRSRNAPRF
>NZ_CP016824.1|WP_067415726.1|5171496_5172531_-|LLM-class-flavin-dependent-oxidoreductase
MHVGSFVLGGQFPGQGQGEALHRAVRSAEVAEEAGLDTVWLGEHHFVPYGTCPSAATLAALLLGRTRRVRVGTAVSVLPTTHPVALGEQAALLHLAADGRFTLGVGRGGPWVDLEVFGAGLPAFEEGFPEALDLLLRWLREPRVGASAEGGRYAFREVAVVPSPAESLDGLPGPEVVVACTSPSSVRLAAERGLPMLLGMHTGDAEKAEMVALWRRHAREAGRDGDEIAAAAHVSAGVAQVEDGPGRATETLVKAMPGWFELGLGAHVTVDGRARAMRDPVAYTEFLCSIHPVGPPRLCADRLAATAEATGITRFALMVEGSGDLAGTEENIRRLGRDVLPLLR
>NZ_CP016824.1|WP_003950896.1|5171009_5171402_+|hypothetical-protein
MSLDVSPALLEQAERGEVDEAAFVDCVRTSLPYAWDMISKLVAQLKVDGGEFADNQTPPPDEQARGQLLRALASDAIRGALQRHFGVRLAFQNCHRVAVFPLSSDSDERHARFTSIRGQLLNQSPELRDC
>NZ_CP016824.1|WP_086014554.1|5170134_5170836_-|endonuclease-NucS
MASGAARRVALPTMRLVIARCSVDYAGRLTAHLPSAPRLILVKADGSVSIHADDRAYKPLNWMSPPCTLKEGEDNVWTVVNKGGEKLVITMEEVLHDSSHELGVDPGLIKDGVEAHLQELLADRIETLGEGYTLIRREYPTAIGPVDILCRDASGATVAVEIKRRGEIDGVEQLTRYLELLNRDPHLAPVRGVFAAQEIKPQARVLATDRGIGCTVLDYNALRGIEDDKLRLF
>NZ_CP016824.1|WP_067415724.1|5167465_5169883_+|ATP-binding-protein
MDPNHRDPHQRGDGDPHRIPGGPQPGAVERRPRPPQGPDLGQPVPPRVRTAELVAGGHLVTVNPVDGSEIEVCPPGRHPSPPVRRTPDDRAALAAAARPPAPPGVPRTHHRLLERDRERDTLVQLLARGRSVRLTGSRGSGRTVLLDAVAARCEGLAPDGVVRLDGHHRTADELLHALCAAVHLLPAHRPGPALLAELAGEIGAVVLIDDAEIGGAALDSFLAATPECAVLLACTPEVPAPGEEARVEEVVLDGIGRSGGLTLLAQGAGRALSDDEVSWAGDLWFESEGLPLRFVQAGALLHQRDLLREESGSAEAPLPTVAEGAAPAALLASRLSEAARATLGFAYALGGEVPHQAHLPALVGDTHADAALTELLDCGLVTPVGNRYRLAAGVTEQLAAEGYADEGERAHTAAQHYTWWTGHPSVTPERAAAESDAVLAALTALVGGQDPARQATAVLLARTVAPVLAAGLAWGAWERVLRSGQEAARLSGEVAEEAYFHHELGILALCQDRLDRARAELEAAVALRGALADKRGTVAGRRALALVADRAGETVPVTRAVLPTDGPPVLPRRDGLGTPPTGFPRTTPAAGVTRVQPAASATGATVVGGPAATAAKDGRPGRAAVTGARRNLVAAGAGALLVAVLGTVVTLGAINGDDEEPASVDRVTTEQTTPEDEGDEGTEAERPADSAEPSTDPGEDGVTGTPDDPTPGDSGSPSESESDEPSSSPTDRPTTSPSDRPTTKPPTTPPTSSKPPTTPPPSSPDPEPSDTTPPTEDPDPEDPEPGTDNSASGPAPEPSTSQTLS
>NZ_CP016824.1|WP_003950906.1|5182633_5183074_-|methylmalonyl-CoA-epimerase
MLTRIDHIGIACHDLDATVEFYRSTYGFEVFHTEVNEEQGVREAMLKINETSDGGASYLQLLEPTREDSAVGKWLAKNGEGVHHIAFGTADVDQDAADIRDKGVRVLYDEPRKGSMGSRITFLHPKDCHGVLTELVTSAPEESAEH
>NZ_CP016824.1|WP_003950907.1|5183217_5184420_+|acetyl-CoA-C-acetyltransferase
MTGTQSTTSVIVAGARTPMGRLLGSLKSFSGADLGSFAIKAALDRAGIGGDQVQYVIMGQVLTAGAGQIPARQAAVKAGIPMNVPALTINKVCLSGLDAIALADQLIRAGEFDVVVAGGQESMTNAPHLLPKSREGYKYGAVEMLDAMAHDGLTDSFENIAMGESTEKHNTRLGIARPEQDEIAALSHQRAAAAQKNGVFEAEITPVEIPQRKGDPVLFAKDEGIRAETTAESLGKLRPAFAKDGTITAGSSSQISDGAAAVVVMSKAKAEELGLEWIAEIGAHGNVSGPDNSLQSQPSNAIAHALKKDGLAVGDLDVIEINEAFAAVAVQSMKDLGVTSEKVNVNGGAIALGHPIGMSGARLVLHLALELKRRGGGIGAAALCGGGGQGDALIVRVPKS
>NZ_CP016824.1|WP_067415732.1|5184508_5185498_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MQDVPALVAQAREGRPRAVARLISLVEGASPQLRDVMAALAPLTGNAYVVGLTGSPGVGKSTTTSALVSAYRAAGKRVAVLAVDPSSPFSGGALLGDRIRMSDHASDPGVYIRSMATRGHLGGLAWAAPQAIRVLDAAGFDLVLVETVGVGQSEVEIAAQADTSVVLLAPGMGDGIQAAKAGILEIGDLYVVNKADRDGADATARELNHMLGLGEARSAGDWRPPIVKTVAAKGVGVDDLVDALEKHGGWMEERGVLAERRVARAAREVETIAVTALRSRIADLSGDARTGALAAQVVGGELSPYAAADVLLDAIAPRALGAPEESAGG
>NZ_CP016824.1|WP_030765280.1|5185613_5186459_-|hypothetical-protein
MTTHRPRPASRPHRSSRALATALAAGTLLATAACSGGQEAPAARESAAAPAHHLERGPSPSPSSRLTEEGARNALITEADIEEQWQKSQAPPQSWRDSLLLGEVDAAQFVTGRSDAKECQRLVDALYDDTLLGKPSGPTALAGFEQGDSRLLYQVAGYDKKTLDASMKWLASLPETCDTFTVTGGKGGRRTVEVTETSLPDEGDARQGLKVQLKGENEGTPLTLTLDVAAVRVGTDAFTVTNGGLDGADAPTTKNAVQHGTQRLEEVQAGHTPAPTPSEIE
>NZ_CP016824.1|WP_008407901.1|5187415_5188081_+|response-regulator-transcription-factor
MRLLIVEDEKRLALSLAKGLTAEGYAVDVVHDGLEGLHRASESPYDLLVLDIMLPGMNGYRVCAALRAAGNDVPILMLTAKDGEYDEAEGLDTGADDYLTKPFSYVVLVARVRALLRRRAGAGASPVHTVGGLRVDTAARRVQRDGEEVTLTAKEFAVLEQLVLRAGEVVSKADILEHVWDFAYDGDPNIVEVYISALRRKLGAQAIRTVRGMGYRLEAGR
>NZ_CP016824.1|WP_010642197.1|5188077_5189505_+|HAMP-domain-containing-protein
MKRLFGSVRAQATIGATLVVAVALIAAGTAVLLSLRSNLIQEAAAQADATARQVASKVAARTAYEDLDLPDDEDRPVQVVDSRGRLLAVSEDLERISGTGTDAVRPDPEALREPGGGNDDDDDGERLEAGEISDEVERGEGTATVDGHTADYRFSAVEVENDDDRLTVWAGAPLAAEQGAVSTAQTVMLIGLPLLLVVVAGVTWGVTGRALKPVEGIRREMAAITASEDLGRRVPEPSTHDEVARLARTTNATLTALEASVERQRSFVADASHELRSPIASLRTQLEVGLAHPELLDVAGAVEDTVRLQALAADLLLLARLDAGERPTGGRLDLGALVREEVSQRVGDRLPVTVHGRAGLEVAGSRGQLARVVGNLVDNAQRHAASRVEVRVRTDGPEAVVSVADDGSGVPEPERERIFERFVRLDDARSRDDGGAGLGLAIARDVAARHGGTLRVREAPEGGALFELRLPRPAD
>NZ_CP016824.1|WP_067415735.1|5189510_5190353_-|hydrolase
MTSGPGEHPGPDRLPDPAARSPEGDGVTVSYEVRHGPPTAEPPGPAATRPKGTPPMADETTGPVTPSPKLLTPDDHALMLIDHESQMGFAVASHPMEVVLNNVTGLAKTAVLFGVPAIVTTVMERHFSGPLFRGVREAFPDTSGWIDRTTMNAWEDPRVRDRYLATGRRKLVLAGLWTEVCVVAPALCALDEGHQVYVVTDACGGVSAEAHERAVQRLVQAGAQPLTWLQYLLELQRDWSRSETASAVGDLARAHGGTYGLGAEYIYQMLAWDRADQAAR
>NZ_CP016824.1|WP_018893529.1|5190349_5190691_-|N-acetyltransferase
MSEPPTADPQTVDVRDDAEANRYEARVGGQLAGTAQYIRTPGLVAFVHTEVDPAYEGHGVGGALVRHSLDEAREQGAAVLAVCPFYAGWISRHPAYRDLLYSEQSRAADGGTR
>NZ_CP016824.1|WP_003950915.1|5190747_5191224_-|MarR-family-transcriptional-regulator
METETATRWLSETEQCVWRTHLDVSRLLMHELEKDLQPFGLTNNDYEILVNLSEAEGQRLRMSDLAEATRQSKSRLSHQITRMEKAGHVRREHCESDRRGLYAVLTEQGASTMEEVAPHHVASVRRHFMDHLSPEALAELSRALGPVAEHLRQRPARG
>NZ_CP016824.1|WP_010642192.1|5191340_5192054_-|hypothetical-protein
MSAFATAGGTGPRIFDPATLPGDDNVNPYTFCVELAGGRWFLQKGKMIAYYGRMSFNGVGYGPLDALVRSAFHSPMHAADWVVAEGTGKMLLADRAYDVNSFDLDDGNLTVRSGNLLAFEPSLSLKQSIVPGFLTLIGTGKFVAASNGPVVFMEPPLRVDPEALVGWADCPSPYHHYDHGYLRGVLGGVRSLTGLGGASGEEHQYEFSGAGTVLLQSTEKVLAERATGAGPGRATTG

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Crispr_ID: NZ_CP016824_32

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_32

5179188-5179692

Orphan

Consensus_repeat	Method
CGCCTCGGCCCGCAGCCGCTCCGCCTCCTCGGC	CRISPRCasFinder

6 spacers

The CRISPR arrays of NZ_CP016824_32

>merge|NZ_CP016824|32|5179188-5179692|CRISPRCasFinder
GGCCTCGGCGACCAGCCGCTCCGCCTCCGCGCGGGCCGCGCCCACCATCGAGTCGGCCCGCGACTCGGCCTCCGTCGTCGCCTTCAGCGCCGCCTGCTGCGCCTCGGTGGTCAGCTTCTCCGCCTCGGCGGCCGTCTCGCTCAGCAGCCGGTCGACCTGCTCGGCCGCCTCCGAGCGCCGCTTGTTGGCGTCGGCCCGCGCCTCGTCCAGCGTCCGGTCGGCCTCCGCGCGTGCCTGCGAGGTCAGTTCCTCGGCCGCGGCCAGCGCCTGAGACTCGACCCGCTCGGCCTCCTCGCGGGCCCGCGCGGCCCGCTCCTCGGCCTCCGCCACGGCGCGCGCCGCCTCGGCCCGCAGCCGCTCCGCCTCCTCGGCCGCCTCGGTCACCGTCCGCTCGGCCTCGGCCCGCGCCTCGGCCCGGAGCCGCTCCGCCTCCTCGGCGGAACGCGCCCCCAGCGACTCGGCCTCCGTGGCCGCCTGCGAGACCAGCCGGTCGGCCTGCTCGGCC

>NZ_CP016824|32|27|5179188-5179692|CRISPRCasFinder
GGCCTCGGCGACCAGCCGCTCCGCCTCCGCGCG	GGCCGCGCCCACCATCGAGTCGGCCCGCGACTCGGCCTCCGTCGTCGCCTTCAGCGCCGCCTGCTG
CGCCTCGGTGGTCAGCTTCTCCGCCTCGGCGGC	CGTCTCGCTCAGCAGCCGGTCGACCTGCTCGGCCGCCTCCGAGCGCCGCTTGTTGGCGTCGGCCCG
CGCCTCGTCCAGCGTCCGGTCGGCCTCCGCGCG	TGCCTGCGAGGTCAGTTCCTCGGCCGCGGCCAG
CGCCTGAGACTCGACCCGCTCGGCCTCCTCGCG	GGCCCGCGCGGCCCGCTCCTCGGCCTCCGCCACGGCGCGCGC
CGCCTCGGCCCGCAGCCGCTCCGCCTCCTCGGC	CGCCTCGGTCACCGTCCGCTCGGCCTCGGCCCG
CGCCTCGGCCCGGAGCCGCTCCGCCTCCTCGGC	GGAACGCGCCCCCAGCGACTCGGCCTCCGTGGC
CGCCTGCGAGACCAGCCGGTCGGCCTGCTCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_010642197.1\|5188077_5189505_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|273593
NZ_CP016824.1\|WP_003950896.1\|5171009_5171402_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_003950899.1\|5172789_5173131_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_018893529.1\|5190349_5190691_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|379642
NZ_CP016824.1\|WP_086014554.1\|5170134_5170836_-\|endonuclease-NucS	unknown	unknown	gnl\|CDD\|235114
NZ_CP016824.1\|WP_008407901.1\|5187415_5188081_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP016824.1\|WP_030765280.1\|5185613_5186459_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225596
NZ_CP016824.1\|WP_010642192.1\|5191340_5192054_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376704
NZ_CP016824.1\|WP_003950915.1\|5190747_5191224_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP016824.1\|WP_003950906.1\|5182633_5183074_-\|methylmalonyl-CoA-epimerase	unknown	unknown	gnl\|CDD\|213772
NZ_CP016824.1\|WP_067415724.1\|5167465_5169883_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223021
NZ_CP016824.1\|WP_003950904.1\|5177362_5178301_-\|cellulose-binding-protein	unknown	unknown	gnl\|CDD\|224117
NZ_CP016824.1\|WP_010642212.1\|5175446_5176217_-\|ABC-transporter-permease-subunit	unknown	unknown	unknown
NZ_CP016824.1\|WP_067415735.1\|5189510_5190353_-\|hydrolase	unknown	unknown	gnl\|CDD\|238494
NZ_CP016824.1\|WP_067415726.1\|5171496_5172531_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NZ_CP016824.1\|WP_067415727.1\|5176218_5177238_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP016824.1\|WP_067415732.1\|5184508_5185498_+\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl\|CDD\|224617
NZ_CP016824.1\|WP_008409337.1\|5173149_5173986_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|372253
NZ_CP016824.1\|WP_008409338.1\|5173982_5175065_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP016824.1\|WP_003950907.1\|5183217_5184420_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|180261

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_010642197.1\|5188077_5189505_+\|HAMP-domain-containing-protein	gnl\|CDD\|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	3.60855e-48
NZ_CP016824.1\|WP_067415732.1\|5184508_5185498_+\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl\|CDD\|224617	COG1703, ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism].	1.06494e-120
NZ_CP016824.1\|WP_018893529.1\|5190349_5190691_-\|N-acetyltransferase	gnl\|CDD\|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	1.80696e-26
NZ_CP016824.1\|WP_086014554.1\|5170134_5170836_-\|endonuclease-NucS	gnl\|CDD\|235114	PRK03298, PRK03298, endonuclease NucS.	1.188e-176
NZ_CP016824.1\|WP_008407901.1\|5187415_5188081_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.92636e-85
NZ_CP016824.1\|WP_003950915.1\|5190747_5191224_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.41125e-16
NZ_CP016824.1\|WP_010642192.1\|5191340_5192054_-\|hypothetical-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	1.25546e-10
NZ_CP016824.1\|WP_030765280.1\|5185613_5186459_-\|hypothetical-protein	gnl\|CDD\|225596	COG3054, COG3054, Predicted transcriptional regulator [General function prediction only].	0.00787616
NZ_CP016824.1\|WP_067415724.1\|5167465_5169883_+\|ATP-binding-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	4.59857e-06
NZ_CP016824.1\|WP_003950904.1\|5177362_5178301_-\|cellulose-binding-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	1.2649e-06
NZ_CP016824.1\|WP_067415735.1\|5189510_5190353_-\|hydrolase	gnl\|CDD\|238494	cd01012, YcaC_related, YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.	2.91417e-61
NZ_CP016824.1\|WP_067415726.1\|5171496_5172531_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	1.30567e-48
NZ_CP016824.1\|WP_067415727.1\|5176218_5177238_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.31275e-89
NZ_CP016824.1\|WP_008409337.1\|5173149_5173986_-\|ABC-transporter-permease-subunit	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	2.32431e-05
NZ_CP016824.1\|WP_003950906.1\|5182633_5183074_-\|methylmalonyl-CoA-epimerase	gnl\|CDD\|213772	TIGR03081, Methylmalonyl-CoA_epimerase_mitochondrial, methylmalonyl-CoA epimerase. Members of this protein family are the enzyme methylmalonyl-CoA epimerase (EC 5.1.99.1), also called methylmalonyl-CoA racemase. This enzyme converts (2R)-methylmalonyl-CoA to (2S)-methylmalonyl-CoA, which is then a substrate for methylmalonyl-CoA mutase (TIGR00642). It is known in bacteria, archaea, and as a mitochondrial protein in animals. It is closely related to lactoylglutathione lyase (TIGR00068), which is also called glyoxylase I, and is also a homodimer.	7.337e-51
NZ_CP016824.1\|WP_008409338.1\|5173982_5175065_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.17964e-91
NZ_CP016824.1\|WP_003950907.1\|5183217_5184420_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0

>NZ_CP016824.1|WP_003950904.1|5177362_5178301_-|cellulose-binding-protein
MSDTSPYGFELVRRGYDRAQVDERISKLVSDRDSALTRITALEKRIEELHLETQNAQAQVADAEPSYAGLGARVEKILRLAEEEAKDLREEARRAAEQHRELAESAAQQVRNDAEAFATERKAKADDEGVRIVEKAKGEASALRAEAQKDAQSKREEADALFEETRAKAAQAAADFETNLAKRREQSERDLASRQAKAEKRLAEIEHRAEQLRLEAEKLRTDAERRARQTVETAQRQAEDIVADANAKADRIRSESERELAALTNRRDSINAQLTNVREMLATLTGAAVAAAGAPAAEDDSASRGVPAQQSR
>NZ_CP016824.1|WP_067415727.1|5176218_5177238_-|ATP-binding-cassette-domain-containing-protein
MIELSGLTKRYGERVAVNNLTFTVRPGIVTGFLGPNGAGKSTTMRMILGLDRPSAGDVRIDGRHYAQLHDPLRQIGALLDAKAMHGGRTAYNHLLCLAQSNGIPASRVTEVLDTVGLTPVARKRAKGFSLGMGQRLGIAGALLGDPRILMFDEPVNGLDPEGIHWIRNLMKSLAHQGRTVFVSSHLMSEMALTAEHLVVIGQGRLMADTSMADFIRENSRSYVTMRSPERERLLDVLHAAGIAVADGPDGAVEVDGVAAPELGELAARERLVLHELSPRQASLEEAFMQLTAESVEYHAHDGDPGAVRGGPGPGAGAASGGEGQWGAGWGGPEQRRRKG
>NZ_CP016824.1|WP_010642212.1|5175446_5176217_-|ABC-transporter-permease-subunit
MAVTQVVRSEWTKIRSVQSTVWTLGLAAVVTIGLGALISALSKSEYENLSPRDQLTFDPTFISFAGLSLGQLAMVVFGVLVVSNEYSTGMIRMSLAAVPQRGTFFFSKVAVATVLALLVSLVTTFATFFLGQALLGNLSASIGDPGVLRAVIGAALYMTLMAVFSMGVAAMLRSPMLSLGILVPFFFLVSSILGAVSATEKIGRFLPDQAGSKIMQVVAPLNDDTPYGPWGGLGIMALWVIAALAIGYALLRHRDA
>NZ_CP016824.1|WP_008409338.1|5173982_5175065_-|ABC-transporter-ATP-binding-protein
MIEATGLTKRYGAKTAVHDLSFQVRPGTVTGFLGPNGSGKSTTMRMIVGLDEPTSGHVTIGGLPYRRVPNAPRQVGALLDAKAVHGGRSARNHLLCLAQLSGIPARRVDEVLGVVGLQDVARHRSKGFSLGMGQRLGIAAALLGDPQVLLFDEPVNGLDPEGILWVRTLMKSLAAEGRTVFVSSHLMSEMALTAEHLIVIGRGRLMADMSVREFIAANAAGFARVRVPDTEPGSREKLAAALAEEGGQVLPEPDGALRVAGLPLPRISDVAHTAGVRLWELSPHQASLEEAYMRLTQGAVDYRSTDDRRAGLHEEGAQGPEPFPVPQPGADQPGWYAPPPPRQERPAAPDLSKSDTEDPR
>NZ_CP016824.1|WP_008409337.1|5173149_5173986_-|ABC-transporter-permease-subunit
MTTPTQQPEQPGALPGAMYTSPIPVRPTHLGHALASEWTKIRSVRSTVWTLCVFVALVVGIGLLVGWKTSGETYTDVPYTIPALFGLMLGQICLITLGVLVVTSEYGTGMIRTTFTAAPQRHRVLAAKFLVFFALAYTVSAVSITVVGLATAAINEIPSGPGENWGTSVLLGSLYVSLLGVLGLAVGSMLRHSAGAITAMLGVVLVPAIMPAFLMISPALRGIGETMLEYNAPNSLSALFGTAMYDGQAGGVPQLLALLGITLVAVAGAFALLEKRDV
>NZ_CP016824.1|WP_003950899.1|5172789_5173131_+|hypothetical-protein
MSPRKNRSKPSRSSGRRGGGDDEPGERYGFQSAESWRGEQWSVRHISGSGPASAGKRYRCPGCDQEIPAGLPHVVAWPEHSGVDERRHWHKACWNAKDRRTTRVQRSRNAPRF
>NZ_CP016824.1|WP_067415726.1|5171496_5172531_-|LLM-class-flavin-dependent-oxidoreductase
MHVGSFVLGGQFPGQGQGEALHRAVRSAEVAEEAGLDTVWLGEHHFVPYGTCPSAATLAALLLGRTRRVRVGTAVSVLPTTHPVALGEQAALLHLAADGRFTLGVGRGGPWVDLEVFGAGLPAFEEGFPEALDLLLRWLREPRVGASAEGGRYAFREVAVVPSPAESLDGLPGPEVVVACTSPSSVRLAAERGLPMLLGMHTGDAEKAEMVALWRRHAREAGRDGDEIAAAAHVSAGVAQVEDGPGRATETLVKAMPGWFELGLGAHVTVDGRARAMRDPVAYTEFLCSIHPVGPPRLCADRLAATAEATGITRFALMVEGSGDLAGTEENIRRLGRDVLPLLR
>NZ_CP016824.1|WP_003950896.1|5171009_5171402_+|hypothetical-protein
MSLDVSPALLEQAERGEVDEAAFVDCVRTSLPYAWDMISKLVAQLKVDGGEFADNQTPPPDEQARGQLLRALASDAIRGALQRHFGVRLAFQNCHRVAVFPLSSDSDERHARFTSIRGQLLNQSPELRDC
>NZ_CP016824.1|WP_086014554.1|5170134_5170836_-|endonuclease-NucS
MASGAARRVALPTMRLVIARCSVDYAGRLTAHLPSAPRLILVKADGSVSIHADDRAYKPLNWMSPPCTLKEGEDNVWTVVNKGGEKLVITMEEVLHDSSHELGVDPGLIKDGVEAHLQELLADRIETLGEGYTLIRREYPTAIGPVDILCRDASGATVAVEIKRRGEIDGVEQLTRYLELLNRDPHLAPVRGVFAAQEIKPQARVLATDRGIGCTVLDYNALRGIEDDKLRLF
>NZ_CP016824.1|WP_067415724.1|5167465_5169883_+|ATP-binding-protein
MDPNHRDPHQRGDGDPHRIPGGPQPGAVERRPRPPQGPDLGQPVPPRVRTAELVAGGHLVTVNPVDGSEIEVCPPGRHPSPPVRRTPDDRAALAAAARPPAPPGVPRTHHRLLERDRERDTLVQLLARGRSVRLTGSRGSGRTVLLDAVAARCEGLAPDGVVRLDGHHRTADELLHALCAAVHLLPAHRPGPALLAELAGEIGAVVLIDDAEIGGAALDSFLAATPECAVLLACTPEVPAPGEEARVEEVVLDGIGRSGGLTLLAQGAGRALSDDEVSWAGDLWFESEGLPLRFVQAGALLHQRDLLREESGSAEAPLPTVAEGAAPAALLASRLSEAARATLGFAYALGGEVPHQAHLPALVGDTHADAALTELLDCGLVTPVGNRYRLAAGVTEQLAAEGYADEGERAHTAAQHYTWWTGHPSVTPERAAAESDAVLAALTALVGGQDPARQATAVLLARTVAPVLAAGLAWGAWERVLRSGQEAARLSGEVAEEAYFHHELGILALCQDRLDRARAELEAAVALRGALADKRGTVAGRRALALVADRAGETVPVTRAVLPTDGPPVLPRRDGLGTPPTGFPRTTPAAGVTRVQPAASATGATVVGGPAATAAKDGRPGRAAVTGARRNLVAAGAGALLVAVLGTVVTLGAINGDDEEPASVDRVTTEQTTPEDEGDEGTEAERPADSAEPSTDPGEDGVTGTPDDPTPGDSGSPSESESDEPSSSPTDRPTTSPSDRPTTKPPTTPPTSSKPPTTPPPSSPDPEPSDTTPPTEDPDPEDPEPGTDNSASGPAPEPSTSQTLS
>NZ_CP016824.1|WP_003950906.1|5182633_5183074_-|methylmalonyl-CoA-epimerase
MLTRIDHIGIACHDLDATVEFYRSTYGFEVFHTEVNEEQGVREAMLKINETSDGGASYLQLLEPTREDSAVGKWLAKNGEGVHHIAFGTADVDQDAADIRDKGVRVLYDEPRKGSMGSRITFLHPKDCHGVLTELVTSAPEESAEH
>NZ_CP016824.1|WP_003950907.1|5183217_5184420_+|acetyl-CoA-C-acetyltransferase
MTGTQSTTSVIVAGARTPMGRLLGSLKSFSGADLGSFAIKAALDRAGIGGDQVQYVIMGQVLTAGAGQIPARQAAVKAGIPMNVPALTINKVCLSGLDAIALADQLIRAGEFDVVVAGGQESMTNAPHLLPKSREGYKYGAVEMLDAMAHDGLTDSFENIAMGESTEKHNTRLGIARPEQDEIAALSHQRAAAAQKNGVFEAEITPVEIPQRKGDPVLFAKDEGIRAETTAESLGKLRPAFAKDGTITAGSSSQISDGAAAVVVMSKAKAEELGLEWIAEIGAHGNVSGPDNSLQSQPSNAIAHALKKDGLAVGDLDVIEINEAFAAVAVQSMKDLGVTSEKVNVNGGAIALGHPIGMSGARLVLHLALELKRRGGGIGAAALCGGGGQGDALIVRVPKS
>NZ_CP016824.1|WP_067415732.1|5184508_5185498_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MQDVPALVAQAREGRPRAVARLISLVEGASPQLRDVMAALAPLTGNAYVVGLTGSPGVGKSTTTSALVSAYRAAGKRVAVLAVDPSSPFSGGALLGDRIRMSDHASDPGVYIRSMATRGHLGGLAWAAPQAIRVLDAAGFDLVLVETVGVGQSEVEIAAQADTSVVLLAPGMGDGIQAAKAGILEIGDLYVVNKADRDGADATARELNHMLGLGEARSAGDWRPPIVKTVAAKGVGVDDLVDALEKHGGWMEERGVLAERRVARAAREVETIAVTALRSRIADLSGDARTGALAAQVVGGELSPYAAADVLLDAIAPRALGAPEESAGG
>NZ_CP016824.1|WP_030765280.1|5185613_5186459_-|hypothetical-protein
MTTHRPRPASRPHRSSRALATALAAGTLLATAACSGGQEAPAARESAAAPAHHLERGPSPSPSSRLTEEGARNALITEADIEEQWQKSQAPPQSWRDSLLLGEVDAAQFVTGRSDAKECQRLVDALYDDTLLGKPSGPTALAGFEQGDSRLLYQVAGYDKKTLDASMKWLASLPETCDTFTVTGGKGGRRTVEVTETSLPDEGDARQGLKVQLKGENEGTPLTLTLDVAAVRVGTDAFTVTNGGLDGADAPTTKNAVQHGTQRLEEVQAGHTPAPTPSEIE
>NZ_CP016824.1|WP_008407901.1|5187415_5188081_+|response-regulator-transcription-factor
MRLLIVEDEKRLALSLAKGLTAEGYAVDVVHDGLEGLHRASESPYDLLVLDIMLPGMNGYRVCAALRAAGNDVPILMLTAKDGEYDEAEGLDTGADDYLTKPFSYVVLVARVRALLRRRAGAGASPVHTVGGLRVDTAARRVQRDGEEVTLTAKEFAVLEQLVLRAGEVVSKADILEHVWDFAYDGDPNIVEVYISALRRKLGAQAIRTVRGMGYRLEAGR
>NZ_CP016824.1|WP_010642197.1|5188077_5189505_+|HAMP-domain-containing-protein
MKRLFGSVRAQATIGATLVVAVALIAAGTAVLLSLRSNLIQEAAAQADATARQVASKVAARTAYEDLDLPDDEDRPVQVVDSRGRLLAVSEDLERISGTGTDAVRPDPEALREPGGGNDDDDDGERLEAGEISDEVERGEGTATVDGHTADYRFSAVEVENDDDRLTVWAGAPLAAEQGAVSTAQTVMLIGLPLLLVVVAGVTWGVTGRALKPVEGIRREMAAITASEDLGRRVPEPSTHDEVARLARTTNATLTALEASVERQRSFVADASHELRSPIASLRTQLEVGLAHPELLDVAGAVEDTVRLQALAADLLLLARLDAGERPTGGRLDLGALVREEVSQRVGDRLPVTVHGRAGLEVAGSRGQLARVVGNLVDNAQRHAASRVEVRVRTDGPEAVVSVADDGSGVPEPERERIFERFVRLDDARSRDDGGAGLGLAIARDVAARHGGTLRVREAPEGGALFELRLPRPAD
>NZ_CP016824.1|WP_067415735.1|5189510_5190353_-|hydrolase
MTSGPGEHPGPDRLPDPAARSPEGDGVTVSYEVRHGPPTAEPPGPAATRPKGTPPMADETTGPVTPSPKLLTPDDHALMLIDHESQMGFAVASHPMEVVLNNVTGLAKTAVLFGVPAIVTTVMERHFSGPLFRGVREAFPDTSGWIDRTTMNAWEDPRVRDRYLATGRRKLVLAGLWTEVCVVAPALCALDEGHQVYVVTDACGGVSAEAHERAVQRLVQAGAQPLTWLQYLLELQRDWSRSETASAVGDLARAHGGTYGLGAEYIYQMLAWDRADQAAR
>NZ_CP016824.1|WP_018893529.1|5190349_5190691_-|N-acetyltransferase
MSEPPTADPQTVDVRDDAEANRYEARVGGQLAGTAQYIRTPGLVAFVHTEVDPAYEGHGVGGALVRHSLDEAREQGAAVLAVCPFYAGWISRHPAYRDLLYSEQSRAADGGTR
>NZ_CP016824.1|WP_003950915.1|5190747_5191224_-|MarR-family-transcriptional-regulator
METETATRWLSETEQCVWRTHLDVSRLLMHELEKDLQPFGLTNNDYEILVNLSEAEGQRLRMSDLAEATRQSKSRLSHQITRMEKAGHVRREHCESDRRGLYAVLTEQGASTMEEVAPHHVASVRRHFMDHLSPEALAELSRALGPVAEHLRQRPARG
>NZ_CP016824.1|WP_010642192.1|5191340_5192054_-|hypothetical-protein
MSAFATAGGTGPRIFDPATLPGDDNVNPYTFCVELAGGRWFLQKGKMIAYYGRMSFNGVGYGPLDALVRSAFHSPMHAADWVVAEGTGKMLLADRAYDVNSFDLDDGNLTVRSGNLLAFEPSLSLKQSIVPGFLTLIGTGKFVAASNGPVVFMEPPLRVDPEALVGWADCPSPYHHYDHGYLRGVLGGVRSLTGLGGASGEEHQYEFSGAGTVLLQSTEKVLAERATGAGPGRATTG

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Crispr_ID: NZ_CP016824_34

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_34

5305611-5305712

Orphan

Consensus_repeat	Method
GGCCTCAAGCGCCGGCCGGGCTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_34

>merge|NZ_CP016824|34|5305611-5305712|CRISPRCasFinder
GGCCTCAAGCGCCGGCCGGGCTGGTTGTGGCCGGGCTTCGGCCTGCGGTGCCGGTGGTCGTCCGTGGCGGTCACCGATGGCCTCAAACGCCGGCCGGGCTGG

>NZ_CP016824|34|29|5305611-5305712|CRISPRCasFinder
GGCCTCAAGCGCCGGCCGGGCTGG	TTGTGGCCGGGCTTCGGCCTGCGGTGCCGGTGGTCGTCCGTGGCGGTCACCGAT
GGCCTCAAACGCCGGCCGGGCTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067415852.1\|5307949_5309458_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NZ_CP016824.1\|WP_067415864.1\|5313547_5316691_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226415
NZ_CP016824.1\|WP_003951011.1\|5305897_5306194_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NZ_CP016824.1\|WP_008410656.1\|5294119_5295289_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NZ_CP016824.1\|WP_008410677.1\|5307692_5307932_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067415850.1\|5303379_5305548_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP016824.1\|WP_003951002.1\|5295311_5296046_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|376556
NZ_CP016824.1\|WP_067415839.1\|5297297_5298074_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP016824.1\|WP_067415858.1\|5312026_5312653_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377085
NZ_CP016824.1\|WP_003951003.1\|5296107_5297253_+\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NZ_CP016824.1\|WP_075986274.1\|5316945_5317815_+\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|379129
NZ_CP016824.1\|WP_003951005.1\|5298577_5299126_+\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|367590
NZ_CP016824.1\|WP_067415861.1\|5312722_5313034_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067415847.1\|5300965_5303152_+\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NZ_CP016824.1\|WP_067415855.1\|5309757_5311992_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP016824.1\|WP_067415842.1\|5298129_5298492_-\|DUF427-domain-containing-protein	unknown	unknown	gnl\|CDD\|377265
NZ_CP016824.1\|WP_030774534.1\|5317845_5318217_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_079165388.1\|5299151_5299850_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181298
NZ_CP016824.1\|WP_003951012.1\|5306199_5307696_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NZ_CP016824.1\|WP_008410671.1\|5299931_5300945_+\|methionine-synthase	unknown	unknown	gnl\|CDD\|239426

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067415852.1\|5307949_5309458_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NZ_CP016824.1\|WP_067415864.1\|5313547_5316691_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	2.1747e-38
NZ_CP016824.1\|WP_003951011.1\|5305897_5306194_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	1.0549e-38
NZ_CP016824.1\|WP_008410656.1\|5294119_5295289_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	2.62768e-160
NZ_CP016824.1\|WP_067415850.1\|5303379_5305548_+\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.6908e-104
NZ_CP016824.1\|WP_003951002.1\|5295311_5296046_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|376556	pfam01510, Amidase_2, N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.	5.8096e-32
NZ_CP016824.1\|WP_067415839.1\|5297297_5298074_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.56551e-11
NZ_CP016824.1\|WP_067415858.1\|5312026_5312653_+\|hypothetical-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	0.00257262
NZ_CP016824.1\|WP_003951003.1\|5296107_5297253_+\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP016824.1\|WP_075986274.1\|5316945_5317815_+\|IS5-family-transposase	gnl\|CDD\|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	3.51561e-25
NZ_CP016824.1\|WP_003951005.1\|5298577_5299126_+\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|367590	pfam03641, Lysine_decarbox, Possible lysine decarboxylase. The members of this family share a highly conserved motif PGGXGTXXE that is probably functionally important. This family includes proteins annotated as lysine decarboxylases, although the evidence for this is not clear.	1.53611e-38
NZ_CP016824.1\|WP_067415847.1\|5300965_5303152_+\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NZ_CP016824.1\|WP_067415855.1\|5309757_5311992_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	2.95876e-92
NZ_CP016824.1\|WP_067415842.1\|5298129_5298492_-\|DUF427-domain-containing-protein	gnl\|CDD\|377265	pfam04248, NTP_transf_9, Domain of unknown function (DUF427). This domain contains a beta-tent fold.	8.7883e-43
NZ_CP016824.1\|WP_079165388.1\|5299151_5299850_+\|SDR-family-oxidoreductase	gnl\|CDD\|181298	PRK08219, PRK08219, SDR family oxidoreductase.	2.79145e-110
NZ_CP016824.1\|WP_003951012.1\|5306199_5307696_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NZ_CP016824.1\|WP_008410671.1\|5299931_5300945_+\|methionine-synthase	gnl\|CDD\|239426	cd03310, CIMS_like, CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by transferring a methyl group from 5-methyltetrahydrofolate to L-homocysteine without using an intermediate methyl carrier. The active enzyme has a dual (beta-alpha)8-barrel structure, and this model covers both the N-and C-terminal barrel, and some single-barrel sequences, mostly from Archaea. It is assumed that the homologous N-terminal barrel has evolved from the C-terminus via gene duplication and has subsequently lost binding sites, and it seems as if the two barrels forming the active enzyme may sometimes reside on different polypeptides. The C-terminal domain incorporates the Zinc ion, which binds and activates homocysteine. Side chains from both barrels contribute to the binding of the folate substrate.	3.47784e-62

>NZ_CP016824.1|WP_067415850.1|5303379_5305548_+|EAL-domain-containing-protein
MEPTESAAPASWPRLRRTIAARTGPRRAPHAPGHAEGVTPLLPIAVIALAAVLLATGIGRAVATGHALFPAGAAGWALAVLTGIVVGHLVALGRDRWWGGTGSGAALTLAVLLLYGWVPAGLVSITVVVLVGVARRHRWRQGLLHGAVDILGIAAAALLLTLTGVTPSVETPWDPRSWTLATGTGVLFAAAGYLLMTRLLLWLVHTPNPGTLPTVTRTAVIRQSLVGVALLGIAPLICVVAVALPVLLPLFSIPLIALDSTLWIARARAEEQLRDPLTGLPNRQWLLERIWTALDEAEQAGTRSALLLIDLDRFRSVNDTLGHLAGDRLLLQIAERLRPALPRGAEAARLGGDEFAVLLPVAASTTAAQRVARRLVSELGSPLDLDGLTLVLEASAGVAVYPDHAQDAEGLLRRADVAMYQAKRDRTGVEVYESKRDSNTPDRLGLLGDLRRALDAGEVELHYQPKVRFDGHVAGLEALVRWVHPERGRVPPDEFIAIAESSGLMPHLTEYVLETALGQVARWRAQGLNVPVAVNVSPRDVHSPGFAGAVAARLARHGVPAGALQLEITEHVLLEDPQRAADTLAGLTGHGVKMSLDDFGTGYSSLVHLRRLPVSELKIDRSFVARLAVDTEDAEIVRCTVDLAHSLGLLVVAEGVEDDETWERLRDLGCDAVQGWLVAAAMPAGETTAWLRARGARGWRRPAEIAAEAAEAGRAVRSGPPQ
>NZ_CP016824.1|WP_067415847.1|5300965_5303152_+|NAD-dependent-DNA-ligase-LigA
MAGEQQNADVPADARERHKHLAEQVEEHRFRYYVNDQPVVSDAEFDRQLRALTELEEQYPPLRTPDSPTQKVAGQYETEFTSVQHRERMLSLDNAFDDEELAAWAERVAKEVGAPGYHFLCELKVDGLAVNLTYEHGRLTRAATRGDGRVGEDITPNVRTISDIPERLHGDDLPALVEVRGEVFFPMEEFEKLNARLVEAGEKPFANPRNAAAGSLRQKDPRVTATRPLHMVVHGIGAREGFTIDCLSHAYDLLRSWGLPTARHNKVVEGLDGVRAFITYYGDHRHSVEHEIDGVVVKLDEVPLQGRLGSTSRAPRWAIAWKYPPEEVNSRLIDIRVGVGRTGRVTPYAQVEPVTVAGSEVEFATLHNQDVVRAKGVLIGDTVVLRKAGDVIPEILGPVADLRDGTERPFTMPAECPECSTPLKPMKEGDIDLRCPNARSCPAQLRERIYYLAGRKCLDIENFGYVAATALTQPLEPSEPPLRDEGDLFDLTVDQLLPIRSYVLDPDSGLPKRDPKTGEEKIVTFFANKQGEAKKNTLAMLDHIEAAKQRPLARVLTGLSIRHVGPVAAQALAREFRSIERIEAATEEELAQTEGVGPTIAASLKSWFAEEWHREIVRKWREAGVRMEEESTGEDEGPRPLEGLTVVVTGTLEHHTRDNAKEALQNQGAKVTGSVSKKTSFVVVGDNPGSKYDKAMQAKVPVLDEAGFAVLLDQGPDAAREVALPLPE
>NZ_CP016824.1|WP_008410671.1|5299931_5300945_+|methionine-synthase
MSDTDDFPTLRATGIGSMPGGDAREAARTVTGTFAGGEGMPYLPELPARGPGADMTGRTAGLLADLHAQLEPSGWRIADRPGRDMRRAVSWLREDLDALEEYTQGYEGPLKLQVTGVWTLAAALQTRGGEAFLGDAGACRDLAASLAEGLRGHLAEVRRRVPGARLVLQLDEPSLTAVLTGTVRTASGYRTYRAVDRQVVESALREVAAVHDGPVLAHSCAPSVPFALLRRAGFAGASFDFSLLTEGDDEALGEGVEAGFRLLAGVVPGTDTALSDPAGSVMGVRTWWRRLGLNPGLLPEAVAITPSCGLAGASPGYARAALAHCVRAANSLADNPE
>NZ_CP016824.1|WP_079165388.1|5299151_5299850_+|SDR-family-oxidoreductase
MRAMATHVITGAGSGIGAAVARRLHERGDHLVLVARDAGRARELAAAHPGAETLVADLADPDRISWALSHQTLPDRIDSLLHIAGVVDLGTVGELPPKTWRHQIDVNLLAPAELTRHFLPQLRLTHGHVVFVNSGAGLNANGGWAAYAAAKHGLKALADALRQEEQEHGVRVTSVYPGRTASAMQQKIHQQEGKEYDPDRWISPESVATTLLTALDLPADAVINDVSIRPGG
>NZ_CP016824.1|WP_003951005.1|5298577_5299126_+|TIGR00730-family-Rossman-fold-protein
MNICVFLSAADLPERYTRPAREFAELLGKGGHTLVWGGSDKGLMKVVADGVEQSGGKLLGVSVEFLAASARPVPAESGEMIITADLAERKAQLLARADAVVIMVGGTGTLDEATEILELKKHGMHTKPVVLLNTAGFYDGLREQFQRMEDEGFLPLPLTELVLFAEEPVGALAHLEESAGVQ
>NZ_CP016824.1|WP_067415842.1|5298129_5298492_-|DUF427-domain-containing-protein
MTQGHGDNTARGHRITVEQAPVHVRVVRDGQVVAESRRPLLLRETGLPVRYYLPPEDVRTDLLTPSETHTVCPFKGTASYWSLPGEPDLVWAYPEPIEAVAEIRDHFCFYETEVVAEPAG
>NZ_CP016824.1|WP_067415839.1|5297297_5298074_-|alpha/beta-hydrolase
MDTVVSRDGTPIAYGTRGSGPALVLVGGAMTAGEHAAPLAGLLADSFTVVTYDRRGRGRSGDTRPYAVGREVEDLAEVIRAVGGPAALYGVSSGAALALHAASAGTAVSRVALYEPPFTVGEADPSRREAYRSRLVALLAADDRGGAVELFMTHIGLPPEMIAGARRSPAWPGLEAVAPTLAYDDELLGDGAPPLDRLALVPVPALVMAGSASPPAMTEAARTVAEALPEGTYRELGGQTHDVAPEAVAAALREFLLP
>NZ_CP016824.1|WP_003951003.1|5296107_5297253_+|tRNA-2-thiouridine(34)-synthase-MnmA
MTETSPRTENPPRPLRVLAAMSGGVDSAVAAARAAEAGHDVTGVHLALSANPQSFRTGARGCCTIEDSRDARRAADVIGIPFYVWDLAERFREDVVEDFVAEYEAGRTPNPCLRCNEKIKFAALLDKALALGFDAVCTGHYATVVTREDGSRELHRASDMAKDQSYVLGVLDERQLAHALFPLGDTLTTKDEIRAEAERRGLAVAKKPDSHDICFIADGDTRGFLAGRLGTAEGDILDEAGQKVGTHEGAYGYTIGQRKGLRIGTPAADGKPRYVLDISPVDNTVTVGPAAALDVTGLTAIRPRWCGTPPEGSGRYTAQLRAHGEETPVTAEVREGELTVTFDEPVRGVAPGQAVVLYDGSRVVGSATIAATRRAGAVPAA
>NZ_CP016824.1|WP_003951002.1|5295311_5296046_-|N-acetylmuramoyl-L-alanine-amidase
MGNGNHSAGAGRGADGGQGARRRTVRRRSVLIGAGVAAATGGVLAREELGRLWYQVPGVSKPRVEGAVDYAKAEWVAASDANWRRADRPDDFTVDRVIIHVVQGSYAVALKVFQDPAHRAATHYVVGKDGRVAQLIRELDVAYQAGNREYNERAVGIEHEGFVDRPQDFTGAMYESSARLTADICLRHGIPVDRTHVIGHVEVPGTDHTDPGPHWDWDRYLRLVRAAKKQLEREREQDERRERA
>NZ_CP016824.1|WP_008410656.1|5294119_5295289_+|cysteine-desulfurase
MAYLDHAATTPMLPEAVEAMSAQLTRTGNASSLHAAGRRARRTAEEARETLAEALGARPSEVVITAGGTEADNLAVKGLYWARRAADPRRTRVLASPVEHHAVLDAVHWLGEHEGATVEYLPVDTLGRVHPEALREALARNPHDVALATVMWANNEIGTVQPVTELAAVAAEYEIPLHADAVQAFGQLPLEFGASGLAAATVSGHKIGGPYGIGALLLGRQYTPVPVLHGGGQERHVRSGTLDVPAIASFAVAGQLAAERRPRFAEEIGALRDELVAAVHDAVPDAILGGDPDPAGRLPANAHFTFPGCEGDSLLLLLDAQGIECSTGSACTAGVAQPSHVLLATGTPPDLARGTLRFSLGHTSTRADVEAVAKAIGPAVERARNAGLS
>NZ_CP016824.1|WP_003951011.1|5305897_5306194_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MPGITREEVAHLARLARLELKAEELEHFAGQLDDILGAVARVSEVAGQDVPPTSHPLPMTNVMRADEVRPSLTPEQALSGAPAQEQQRFKVPQILGED
>NZ_CP016824.1|WP_003951012.1|5306199_5307696_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MSDSIIKLTAAETAAKIASGELTAVEVTEAHLARIEAVDEKVHAFLHVDREGALAQARAVDAKRAAGEKLGPLAGVPLALKDIFTTEGIPTTVGSKILEGWIPPYDATVTKRLKDADVVILGKTNMDEFAMGSSTENSAYGPTGNPWDLTRIPGGSGGGSSAALAAFEAPLAIGTDTGGSIRQPAAVTGTVGVKPTYGGVSRYGMVAFSSSLDQGGPCARTVLDAALLHEAIAGHDPLDSTSIDAPVPPVVEAARNGSVAGMRVGVVKQFRGEGYQAGVVQRFDESVELLRKLGATVVELDCPSFDLALSAYYLIAPSECSSNLARFDAMRYGLRVGDDGTRSAEEVTAITREEGFGDEVKRRVILGTYALSSGYYDAYYGSAQKVRTLITRDFERAFEEVDVIVSPTTPTTAFPIGERADDPMAMYLADLCTIPTNLAGNAAMSLPCGLAPEDGLPVGLQIIAPAMKDDRLYKVGAAVEAAFVEQWGHPLLEEAPSL
>NZ_CP016824.1|WP_008410677.1|5307692_5307932_+|hypothetical-protein
MSALSKAKGFKKSKTGTYLSIGTTAFGALSVYKQMKAARHDHDTLSLVDAVATAAGIVTGVALLVRELKRLGDDDVLLG
>NZ_CP016824.1|WP_067415852.1|5307949_5309458_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MTVTDLVPYDDALAAYDPVMGLEVHVELGTKTKMFCGCSTELGADANSQTCPTCLGLPGSLPVVNAVGVESAVKIGLALHCEIAEWCRFARKNYFYPDMPKNFQTSQYDEPIAFDGYLDVQLEDGEVFRVEIERAHMEEDTGKSTHVGGATGRIHGASHSLLDYNRAGIPLIEIVTKPIEGAGERGPEVAKAYVAELRELIKALGVSEARMEMGQMRCDVNLSLRPKGRQEFGTRSETKNVNSLRSVERAARFEIQRHAAVLSSGGTIVQETRHFHEEDGSTTAGRIKDNAEDYRYFPEPDLVPVAPPREWVEELRSTLPELPRVRRNRLREEWGVSEHDMQSILNAGAIGPIVATIEAGADAAAARKWWMGELARNANETGRPLEGLPITPAQVARVAELVKGGDLNDKLARQVIEGVLAGEGDPDTVVEKRGLKVVSDEGALTTAVEEAIAGNPAIADKIRGGKVAAAGALVGAVMKATRGQADAARVKELILAQLGVEG
>NZ_CP016824.1|WP_067415855.1|5309757_5311992_+|MMPL-family-transporter
MAALARWCMHHRLLAVLLWLLVLGGAGTAAGLAGSAYTNDYAAGGTESGEATALIERGFPGLAGDSDTVVWHAPDSSVRAADVEQTMTHALDRIADLPGVASVAGPYAEAGTGPGGGISEDGRTAYATVTFAAQTSDISPAQAQAVVNAAHGADGDGLQVEVGGSAVALTEAPALHTAELIGVAVAAVVLFLAFGSLAASLLPIATALVSVGIAYAGIVLLGHVMTVADFAPMLGMLIGLGVGIDYALFIVTRHRTGLKQGLTVDAAAARAVATTGRAVVFAGATVCIALLGMLILRLEFLNGVAIAASLTVLLTVAASLTLLPALLAYIGPRALSRRERRRLAAEGPLPELPTGFAARWSRFVERHPKLLGVLATAVMAVLALPMLTLHLGTSDQGNNPASSTTRQAYDLLADEFGPGVNGPLTLVTEVGGAPDRLALDGLEQTLRQTEGVAGVTPVVFNDASDTALLTVVPTSSPQSEQTSALVDRLRADVLPRAEAGTGLDLKVGGMTAAYDDFAELIVGKLPLFIGVVIGLGFALLLLAFRSVGIPLKAALMNVMAVAGAFGVVVAIFQWGWGSELLGLGSSGPIEPFLPVIMVSVLFGLSMDYQVFLVSRMHEEWVATGDNTRAVRVGLAETGRVINSAAVIMISVFLAFVLSGDRLIAMFGIALAVAVALDAFVLRTLLVPALMHLLGRANWWLPGWLDRVLPRISIEGPPEQRAAHPAEVPVPRAPDEDPARSAALR
>NZ_CP016824.1|WP_067415858.1|5312026_5312653_+|hypothetical-protein
MDTKTADGKRPATGAEGEQQDTDGTTPGKTPGEEKDPAGRGAPAAAETDGDEAVHDAHDADDLDADDEVAADDSATAAPTGIAAGAAAIVSVVLGVVSLTGGWLGTIASARASLIGQLETSQGAGVADQVQAIYGDSWEAAALVGGAFAAVGLLVGIGVVLRVAYWPARTGPVWVRSAAWAGVAVGLVGLLLALSKYTGLLLGVPSAG
>NZ_CP016824.1|WP_067415861.1|5312722_5313034_-|hypothetical-protein
MSRLPAACLHTHLFRGARFLVDGLADPSGYARAPRPLELALRFSDDAPADAEVLVSPDSGETVLAVGAYTTEAGTSLSSRKWLVGGVEARNAGVELTIGVRVG
>NZ_CP016824.1|WP_067415864.1|5313547_5316691_+|helix-turn-helix-transcriptional-regulator
MLTDVEHKSVSPVFVGRATELDTLRRALTEVRTGEPRALLIGGEAGVGKTRLLEEFTAEATGDEALVALGACVESGTEGLPFAPFAAVLRTLRRLLPEEFAAGAAGQEGELARLLPDLGEAALARSGEEGTARLFDLTARLLEHLAAARPVVLVVEDLHWADASTRRLIAYLFRTLRTGRLLVLASYRADDIHRRHPLRPLLAELDRLRTVQRLELPRFNRAEVAGQLAGILAAEPDDSTVDEVFARSEGNAFFVEELTVAARSGCHAGLTDSLRDLLLVRVEALPERSQHLVRLAAEAGPTTEYALLAAVARLPETDQLDALRAAVGAHILLPSEDGDGYRFRHALVREAVTDDLLPGERTRIGRQFAEALAADPTLVAPDAYATRLAGYWYRAHDAAKALPAVLRAAAEARHRHAYAEQFTLLERAMELWDGVPEEIRGALRSADHAEVYPHLTARRGPGTGEGPGAPLRYLHLMADAAVAGRLCGQRERAYKIAKKAVRMLGETRSTGESWDEPLFAAWFWVQRSRVAESVGRGDGWQELHTAQELVRGLPPSEMHAEVLSCVASWWMLHRPGPEAYAAAERAVQYARMVGADDDVELAARGTLAGLRIDSGDIDTGLAELREVLADALRRERPHQIGRCYVNLPSHLEGIGRSAEAAALIERGLKESDRYGLLFTATFLHANHAESLISLGRWDEALRSADAAAGLTGQAKPAGMAAHSRTVIALARGDLDTAVRQDAVARSRVGSHGAMPQHALPLATTRLSIAAAEGRVHDARAELRAAAETGFPPGTQRYAWPLLVAAATTESDARGLPGAEEGRADHIALVRRLAKNLVTFVPVCEAQAAWVRAELRRGKGQDTVEDWADVHQRFLPLERPWDLARVALRYAEALLADSGTRPGPGRTQAAELLRTARATARRLGARPLADSIDLLARRARLSLSTRPAATPRPDTPTDPAEALGLTRREREVLSLLVAGRTNRHIAEELFISPKTASVHVSHILAKLEVSSRGEAAAVAHRLRLVGSGAGGSGGEGGREKGVGVGVGA
>NZ_CP016824.1|WP_075986274.1|5316945_5317815_+|IS5-family-transposase
MGRGGLSDGQWAVLEPLLPVTVLGRPSWGRRKLIDGIRWRVRTGAPWRDLPLQYGPWQTVYGLFRRWQRDGIWPGLLTRLQARADVAGLITWEVNADSTLCGAHQHAAGARRDGQAQKEPPGGSRAERDDHGLGWSRGGFTTKIHLACEQGQRRLSLLVTAGQRGDSPQFVAVLEGIRVPRTGPGRPRVRPLRVRGDKAYSSSANRANLRKCGIRCAIPEPADQVAHRKRRGKAGGRPPDFDREGHRARHTVECWINRLKRNRAVATRFDKLAVRFEATVLIAAIGEWL
>NZ_CP016824.1|WP_030774534.1|5317845_5318217_+|hypothetical-protein
MLTATRVDSEGKATVAAQYYGADSENGDRIDDPSEDALFMMISDLNDSDNTFVVVQPDEDDPVWFASVAVLDEGGYETVRRDTTRNEHEVTMATSVNDIARDLTIWMAARDFPGRPTSQVSES

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Crispr_ID: NZ_CP016824_35

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_35

5678577-5678660

Orphan

Consensus_repeat	Method
ACTGTTCCCCGCATGCGCGGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_35

>merge|NZ_CP016824|35|5678577-5678660|CRISPRCasFinder
ACTGTTCCCCGCATGCGCGGGGGTGGACCCGCGTGGTCGAGGGTCGCGGGGTGGGCGTACCACTGTTCCCCGCACGCGCGGGGG

>NZ_CP016824|35|30|5678577-5678660|CRISPRCasFinder
ACTGTTCCCCGCATGCGCGGGGG	TGGACCCGCGTGGTCGAGGGTCGCGGGGTGGGCGTACC
ACTGTTCCCCGCACGCGCGGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_003951325.1\|5682645_5683245_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067416233.1\|5689136_5690486_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|281959
NZ_CP016824.1\|WP_030770684.1\|5683244_5684426_+\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366747
NZ_CP016824.1\|WP_067416227.1\|5686419_5687454_-\|DUF3071-domain-containing-protein	unknown	unknown	gnl\|CDD\|378619
NZ_CP016824.1\|WP_026048248.1\|5662327_5663353_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380515
NZ_CP016824.1\|WP_003951312.1\|5665935_5666811_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP016824.1\|WP_067416224.1\|5685515_5686343_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NZ_CP016824.1\|WP_067416222.1\|5684469_5685270_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NZ_CP016824.1\|WP_008406647.1\|5690412_5691687_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP016824.1\|WP_018469409.1\|5673758_5675150_+\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NZ_CP016824.1\|WP_010641674.1\|5669756_5672204_-\|DNA-topoisomerase-IV-subunit-A	unknown	unknown	gnl\|CDD\|235503
NZ_CP016824.1\|WP_018469410.1\|5672401_5673766_+\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NZ_CP016824.1\|WP_067416230.1\|5687932_5689117_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223039
NZ_CP016824.1\|WP_079165401.1\|5679246_5679546_-\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|273389
NZ_CP016824.1\|WP_067416219.1\|5679675_5682555_+\|bifunctional-GNAT-family-N-acetyltransferase/acetate--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|131764
NZ_CP016824.1\|WP_018469408.1\|5675561_5676335_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP016824.1\|WP_067416216.1\|5668555_5669674_+\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|223597
NZ_CP016824.1\|WP_008406666.1\|5676556_5677243_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP016824.1\|WP_030310488.1\|5664962_5665925_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP016824.1\|WP_067416213.1\|5666848_5668444_+\|glycoside-hydrolase-family-13-protein	unknown	unknown	gnl\|CDD\|200471

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067416233.1\|5689136_5690486_-\|FAD-binding-protein	gnl\|CDD\|281959	pfam04030, ALO, D-arabinono-1,4-lactone oxidase. This domain is specific to D-arabinono-1,4-lactone oxidase EC:1.1.3.-, which is involved in the final step of the D-erythroascorbic acid biosynthesis pathway.	8.2747e-115
NZ_CP016824.1\|WP_030770684.1\|5683244_5684426_+\|alkaline-phosphatase-family-protein	gnl\|CDD\|366747	pfam01663, Phosphodiest, Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.	9.86342e-40
NZ_CP016824.1\|WP_067416227.1\|5686419_5687454_-\|DUF3071-domain-containing-protein	gnl\|CDD\|378619	pfam11268, DUF3071, Protein of unknown function (DUF3071). Some members in this family of proteins are annotated as DNA-binding proteins however this cannot be confirmed. Currently no function is known.	3.01174e-61
NZ_CP016824.1\|WP_026048248.1\|5662327_5663353_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|380515	cd06292, PBP1_AglR_RafR-like, Ligand-binding domain of uncharacterized DNA transcription repressors highly similar to that of the repressors specific raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators. This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins highly similar to DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR). Members of this group belong to the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.59934e-95
NZ_CP016824.1\|WP_003951312.1\|5665935_5666811_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.87658e-65
NZ_CP016824.1\|WP_067416224.1\|5685515_5686343_+\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	1.31086e-81
NZ_CP016824.1\|WP_067416222.1\|5684469_5685270_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	4.12901e-30
NZ_CP016824.1\|WP_008406647.1\|5690412_5691687_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.43622e-19
NZ_CP016824.1\|WP_018469409.1\|5673758_5675150_+\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	5.41846e-60
NZ_CP016824.1\|WP_010641674.1\|5669756_5672204_-\|DNA-topoisomerase-IV-subunit-A	gnl\|CDD\|235503	PRK05561, PRK05561, DNA topoisomerase 4 subunit A.	0
NZ_CP016824.1\|WP_018469410.1\|5672401_5673766_+\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	1.23389e-75
NZ_CP016824.1\|WP_067416230.1\|5687932_5689117_+\|hypothetical-protein	gnl\|CDD\|223039	PHA03307, PHA03307, transcriptional regulator ICP4; Provisional.	3.35052e-05
NZ_CP016824.1\|WP_079165401.1\|5679246_5679546_-\|HPr-family-phosphocarrier-protein	gnl\|CDD\|273389	TIGR01003, Phosphocarrier_protein_HPr, Phosphotransferase System HPr (HPr) Family. The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS].	2.97148e-21
NZ_CP016824.1\|WP_067416219.1\|5679675_5682555_+\|bifunctional-GNAT-family-N-acetyltransferase/acetate--CoA-ligase-family-protein	gnl\|CDD\|131764	TIGR02717, Uncharacterized_protein_MJ0590, acetyl coenzyme A synthetase (ADP forming), alpha domain. Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.	3.74599e-105
NZ_CP016824.1\|WP_018469408.1\|5675561_5676335_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	4.89112e-36
NZ_CP016824.1\|WP_067416216.1\|5668555_5669674_+\|GTP-binding-protein	gnl\|CDD\|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	1.13413e-66
NZ_CP016824.1\|WP_008406666.1\|5676556_5677243_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	4.24177e-41
NZ_CP016824.1\|WP_030310488.1\|5664962_5665925_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.24826e-74
NZ_CP016824.1\|WP_067416213.1\|5666848_5668444_+\|glycoside-hydrolase-family-13-protein	gnl\|CDD\|200471	cd11332, AmyAc_OligoGlu_TS, Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins. Oligo-1,6-glucosidase (EC 3.2.1.10) hydrolyzes the alpha-1,6-glucosidic linkage of isomaltooligosaccharides, pannose, and dextran. Unlike alpha-1,4-glucosidases (EC 3.2.1.20), it fails to hydrolyze the alpha-1,4-glucosidic bonds of maltosaccharides. Trehalose synthase (EC 5.4.99.16) catalyzes the isomerization of maltose to produce trehalulose. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0

>NZ_CP016824.1|WP_008406666.1|5676556_5677243_+|GntR-family-transcriptional-regulator
MGIPAQSVCTAIREDIVSGVHERGSRLTEEQLARRYGVSRVPVREALRTLEAEGFVVTRRHAGACVAEPTEQEAADLLEIRMLLEPLGAARAARRRTEAHLKVLRGLVRLGQERARLGEGEDLRSLGAWFHETLAQASGSPGLTALLTQLRQKVTWMYAVDPPAAPAESWAEHGAIVDAVARGDAERARALTAQHAERATAVHRLRFGSRTTGVRTSQHAVNIPGGRN
>NZ_CP016824.1|WP_018469408.1|5675561_5676335_+|M23-family-metallopeptidase
MAFTRPTGKHRRPHRRAARTGAGLAGVAALTTTGVVSTLASPAAAAEAPAHTGFTEAIVIGHSLADRIDDQAAAQRLAAEDAAAEQAAVEAARLQAAEAKRKAEKKRAEKVRAARAAERERLNRYVLPVEGSYVSTGYQTGGSLWSSGSHSGVDFHAPAGSAVRAVGAGTVVETGWGGAYGNEVVIQMHDGTYTQYGHLASATVSVGQTVTPGQQIAVSGSTGNSTGPHLHFEARSGADYGTDMDPVAYLRGHGVDV
>NZ_CP016824.1|WP_018469409.1|5673758_5675150_+|insulinase-family-protein
MSDVITPAMDLHPQPAGGAPRPWAFPAPERTTLDNGLTVLTCHRPGQQVVAVEVLLDSPLDTEPEGLDGLATIMARAFSEGTDRDSAEEFAAELERCGATLDAFADHPGVRLSLEVPVSRLEKALGLLADALRAPAFAEAEIERLVRNRLDEIPHEQANPARRAAKELSRQLFPAGSRVSRPRQGTEETVERIDAAAVRAFYERHVRPATATAVVVGDLEGTDLGALLAGSLGAWQGDAGQPNPVPPVTADDTGRVVIVDRPGAVQTQLLIGRVGPDRHDRVWPAQVLGTYSLGGTLTSRLDRVLREEKGYTYGVRSFAQVLRSTPEGTGAAMLAISGSVDTESTGPALDDLWKVLRTLAAEGLTDAELDTAVQNLVGVAPLKYETAAAVASTLADQVEQHLPDDFQARLYRMMTETGATEATAAVVSAFPADRLVTVLVGDASRIAEPVRALGIGEVSVVTG
>NZ_CP016824.1|WP_018469410.1|5672401_5673766_+|insulinase-family-protein
MGDTATARAASGGLTATEHRLANGLRVVLSEDHLTPVAAVCLWYDVGSRHEVKGRTGLAHLFEHLMFQGSAQVKGNGHFELVQGAGGSLNGTTSFERTNYFETMPAHQLELALWLEADRMGTLLTALDDESMENQRDVVKNERRQRYDNVPYGTAFEKLTALAYPEGHPYHHTPIGSMADLDAATLEDAREFFRTYYAPNNAVLSVVGDIDPGQTLAWIEKYFGSIPGHEGKRPPRDGSLPDTIGSELREVVREEVPARALMAAYRLPEDGTRAADAADVALTVLGGGESSRLYNRLVRRDRSAVAAGFGLLRLAGAPSLGWLDVKASGDVEIPAIETAVDEELARFAAEGPTAEEMERAQAQLEREWLDRLGTVAGRADELCRYAVLFGDPQLALTAVGRVLDVTADEVRQAAAERLRPDNRAVLVYEPLTAEEAGPADQTDTATGEEAAASE
>NZ_CP016824.1|WP_010641674.1|5669756_5672204_-|DNA-topoisomerase-IV-subunit-A
MARRSTKTPPPDDFEERILDIDVVDEMQGSFLEYAYSVIYSRALPDARDGMKPVHRRIVYQMNEMGLRRDRGYVKCARVVGEVMGKLHPHGDASIYDALVRMAQPFSMRLPLVDGHGNFGSLGNDDPPAAMRYTECRMADATSLMTESIDENTVDFSPNYDGQEQEPVALPAAFPNLLVNGASGIAVGMATNMPPHNLGEVVAAARHLIKHPGADLETLMRFVPGPDLPTGGRIVGLGGVRDAYATGRGTFKIRATVAVENVTARRKGLVVTELPFSVGPEKVISKIKDLVGAKKLQGIADVKDLTDREHGLRLVIEIKNGFVPEAVLEQLYKLTPMEESFGINNVALVDGQPLTLGLKELLEVYLDHRFTVVRRRSEFRRGKKRDRLHLVEGLLVALVDIDEVIRIIRDSENSAEARERLMERFSLSDIQTQYILDTPLRRLTRFDRIELESERDRLTAEIEELSRILDSDAELRKLVSSELAAVSKKYGTDRRTVLLESSGAAAAVPLQVEDTPCRVLLSSTGLLARTADATPLAEAPKRVKHDLIVSAVAATARGEVGAVTSAGRLLRLQVIDLPQLPGTDTAPSLSGGAPVAEFLTLEADERLVCLTTLDESSPGLALGTAQGVVKRVVPDYPSHKEELEVISLRDGDRIVGATELRTGEEDLVFITDEAHLLRFPASVVRPQGRPAGGMAGVKLGEGARVVSFTAVDPAVDAVVFTVAGSRGTLDDSVQTTAKVTPFDQYPRKGRATGGVRCQRFLKGEDCLSFAWAGPAPAHAAQRDGSPAPLPELDPRRDGSGLSLPKPVAAAAGPVG
>NZ_CP016824.1|WP_067416216.1|5668555_5669674_+|GTP-binding-protein
MGRQQIPVVVLAGFLGSGKTTLLNQLLWRSGGTRIGAVVNDFGAIEIDAMTVAGQVGSTVSLGNGCLCCAVDVAELDTYLERLTRPEAGLDVIVIEASGLAEPVELVRMILASENPHIRYGGLVEVVDAAEYEATRERHPELDRHLAAADLVVLNKTDRVTPAELAELLTAVRERAGDGAVTPASYGRIDPELLFDRRPQTERYGQLSFDDAREEDEPGGGREDHDDHDGHLHAAYDSASFTTGTPLHPRRLMDLLDGRPEGLYRIKGFVDFGPLDPGHVYTLHAVGRFLRFAPRPWEPGEERRTQLVLIGAGIDPDALTAQLEGCRDAAREAEERHLWSVLRFVRAEEDTADPDDPEALRAAAPGTEQPVA
>NZ_CP016824.1|WP_067416213.1|5666848_5668444_+|glycoside-hydrolase-family-13-protein
MPDSDWWRSAVIYQVYVRSFADADGDGTGDLAGVRAKLPYLAQLGVDALWFNPWYASPMADGGYDVADYRAIHPSFGTLAEAEKLIEEAAGHGIRTIVDIVPNHVSEAHPWFRAALAEGPGGPSRDLFHFRPGRGEHGELVPNDWQSEFGGPAWTRLPDGEWYLHLFAPEQPDLNWAHPAVRTEHEEILRFWFERGVAGVRIDSAALPAKDPALPDFTPGQDPHPYLDRDELHDIYRSWRAVADRYGAVFVGEVWLPDSERFARYLRPDELHTAFNFAFLSCPWEPERLRAAIRDTLAEHAPVGAPATWVLCNHDITRTVTRYGRAETGFDFAAKRFGTPTDPALGTRRARAAALLSLALPGATYLYQGEELGLPEAEIPREHIEDPMHARSGGVDPGRDGCRVPLPWTADAPHAGFSTGEPWLPQPPGWAAHAADLQDGDPASMLTLYRTALALRRATPGLGDGPLEWLESPEEVLAFRRPGGVLCLVNLGVGPVPVPEGTELLLASGPLGADGALPSDTAVWLREPAAA
>NZ_CP016824.1|WP_003951312.1|5665935_5666811_+|carbohydrate-ABC-transporter-permease
MTTRTLISPARLSRPRGRILYWTVLFLVVAVFTLVFIGPLYWMVTSGLKDTEEFARIPPTLVPDAVHPGNYGEAWQVMELSQLLFNTLYYAFGALAFQLVLDVAAAYSLSKLRPVLGKAILGAMLVTLMIPATVLVVPQYLTVLDLPVFERNLLNTPWVIWLPSVTNAFNIFLLKRFFDSIPRELLDAAAIDGASPMRTLRSVVLPISRPILGVVSIFAVVGVWKDFLWPMLALPDPGKQTLNVGIYSLASGVPENWLLAALAMASLPTLILFLIFQRNIMSGLTAGGLKG
>NZ_CP016824.1|WP_030310488.1|5664962_5665925_+|sugar-ABC-transporter-permease
MAPPTSTPTLTRRPAGTDDGAPRVKEPRQGAFARAVRRNLTAHAFLIGAVLCFGFFSWYPMVREVVLAFQKTENGVVSWAGWSNFVYVFNDPDFALAWRNTALFTLLALLLGFVVPFVIALVLNEFRHARGYLRLLVYLPVMLPPVASVLLFKYFYDPGHGLFNRLLELFGLPAQQWLQSSDTAMLSLVIASTWMNMGGACLIYLAALQTIPGELYEAAELDGAGLLRKIWHVTIPQTRLILSLLFLMQIIATMQVFTEPFLLTGGAGPEGSTTTVVHLIYQYAFNFNNYGAAAALGLVLLVVLAGFSAAYVRLNRAEQE
>NZ_CP016824.1|WP_026048248.1|5662327_5663353_+|LacI-family-transcriptional-regulator
MTRRLAQVAQKVGVSEATVSRVLNGKPGVSDSTRQAVLSALDVLGYERPTQLRGERARLVGLVLPELQNPIFPAFAEVVGGALAQQGLTPVLCTQTKGGVSEADYVALLLQQQVSGVVFAGGLYAQAAAPHDHYRQLADRNIPVVLINAAIGELGFPTVSCDDTVAVEQAWRHLASLGHERIGLVLGPEDHMPSRRKLAAARAAAQALGTELDDADVVRAMFSLEGGQAAATRLLERGITGIVCASDPLALGAVRAVRRRGLSVPEDVSVVGYDDSAFMNCTEPPLTTVRQPIEAMGRAAVELLTVQIGGSAVPGEELLFEPELVVRGSTAQAPRAGTAAG
>NZ_CP016824.1|WP_079165401.1|5679246_5679546_-|HPr-family-phosphocarrier-protein
MKGSFNMAERRVNVGWAEGLHARPASIFVRAATASGIPVTIAKPDTAPVNAASMLAVLGLGVQGGEEIVLSADADGAEATLERLARLVAEGLDELPETV
>NZ_CP016824.1|WP_067416219.1|5679675_5682555_+|bifunctional-GNAT-family-N-acetyltransferase/acetate--CoA-ligase-family-protein
MDTPSDQHAYPAHWEADVVLRDGGTARIRPITADDADRLVSFYEQVSDESKYYRFFAPYPRLSAKDVRRFTHHDHVDRVGLAVTIGGEFIATVRYDRIDDRGMPASAPADEAEVAFLVQDAHQGRGVASALLEHIAAVARERGIRRFTAEVLPANTKMIKVFTDAGYQQKRSFEDGVVRLEFGLEPTDRSLAVQHAREQRAEARSVQRLLAPGSVAVVGVGRTLGGVGRSILRNIREAGFTGPVHAVNQGFPDTGDTVEGVRAHRSVRDIAEPVDLAVIAVPAERVPEAVAECGEHGVQGLVVISAGYAEQGPEGRERQRALIRQARSYGMRVIGPNAFGVINTTPETRLNASLAPELPVPGRVGLFTQSGAIGIALLSALHRDGGGADGVPNPTGVSTFVSAGNRADVSGNDVMQYWYDDPHTDVALMYLETIGNPRKFTRLARRTAAAKPLVVVQGARHSGITPTGHPAPVTRLPYATVSALLRQAGVIRVDTVTELVDVGLLLAGQPLPAGPRVAILGNSESLGLLSYDACLSQGLRPLPPRDLTTDATPEDFRAALAAALADDGCDAVVVTAIPWVGADGVPERPDGEALGAALRTAHATAPDKPVVVVHVELGGLAEALSAAAGTGPGSPATQRGPAPSPAAPDSAAPAPDEAPPVPRTRRIPAYPAAERAVRALGEAVRYAQWRREAQRPGGVPEYESIDERGAAADITRLLAAAAPGEEGAAPRAHTLGAEDTRALLARYGIEVRPTLPAPDPDTAVRAAAELGYPVALKTTAPHLRHRADLGGVRLDLADEAQLRQAYAELTGLFGTPAELRPVVQPMAPRGVDTVVRTVIDPAVGAVLTFGLAGAPSELLGDTAHRLVPVTDRDATAMVRSIRTAPLLFGWRGSAPVDTPALEELLQRVSRLVDDHPEVVDVQLEPVVVAPRGVSVLGASVRLAPPPPRDDLGPRTLPAY
>NZ_CP016824.1|WP_003951325.1|5682645_5683245_+|hypothetical-protein
MAKTGTTTQGLRAAIERSGYYPALVAEAVEAAVGGEPVASYLVHQETTFDANEVRRHVTVLVLTPTRFIVSHTDEQAADSGSPTALATTSTESVKTGRISSVVLSRVVANPESYTPGTLPREVVLTIGWGAVSRIDLEPAACGDPNCEADHGYTGSSTADDLSLRVSEAGDGPDTVRQALAFAQALSEATAATATPAGR
>NZ_CP016824.1|WP_030770684.1|5683244_5684426_+|alkaline-phosphatase-family-protein
MPSSAWPEPLPLASAPVPAYGSGSLADLLPTLAAGSGVPGMTATLTELPPADRNCVFLIDGLGWHQLLAHPAEAPFLSSLIPTSRGGTGQPLTAGFPATTATSLASVGTGRTPGEHGLPGYTALNPDSGELMNQLRWKPWTDPHAWQPHPTVFSLADAAGVHTAQVSAPGFHHTPLTQVALSGGTFHGRLSGEERMDLAAAQLAAGDRALVYTYYSEVDGKGHRFGVDSDAWRGQLMYVDGLARRLAEQLPPRSALYITADHGMVDIPFDDRHRFDVDEDWELNAGIRLLGGEGRARHLYAVPGAARDVRTVWREVLGEQCWVAGRDEAIEAGWFGPHVEKRVRDRLGDVIVAARDDVAITATRREPNESALTGMHGSMTPAEQLVPLLEVRT
>NZ_CP016824.1|WP_067416222.1|5684469_5685270_-|VOC-family-protein
MSVVRGQTVDQRTERPVPGTPCWVSLMADDLVASQEFYGRLFGWEFRPGPEQLGPYARALLDGRVVAGIGRMPEGQSLPVAWTPYLAADDVDETAGTVRHCGGTVGVGPLDAEEAGRMALTADPSGATFGIWQGREHRGAAVEGVPGSVLWNELVTRETAGVLPFYRAAFGFEAEREEAAEDAATLLLDGRPVASVLGVGQALGELGAAHWHTHFAVEDPDETVNRVIELGGRVQRPPRDGSHGRTATVADPWGAVFTVARPDTRA
>NZ_CP016824.1|WP_067416224.1|5685515_5686343_+|sulfurtransferase
MNAIISATALAGELQGPRPPVLLDVRWQLGGPDQRPAYLAGHLPGAVHVDLDGELAGGPGKGGRHPLPDVEAFGAAMRAAGVDAGRPVVTYDGGQGWAAARAWWLLRWAGHPEVRVLDGGLAAWDGPLEEGEVTPEPGDFTPEPGRLELLDADGAAALAASGVLLDARAAERYRGDVEPIDRVGGHIPGAVAAPTTENTGEDGRLLPAAELADRFAALGANPGRKVGVYCGSGVSGAHEVLALAVAGVDAALYVGSWSDWSADPDRPVATGPQPG
>NZ_CP016824.1|WP_067416227.1|5686419_5687454_-|DUF3071-domain-containing-protein
MPELRVVAVSNDGTRLVLKAADSTEYTLPIDERLRAAVRGDRPRLGQIEIEVESHLRPRDIQARIRAGASAEEVASLAGIPVDRVRRFEGPVLAERAFMAERARKTPVRRPGENTGPQLGEAVRERLLLRGADRDTVQWDSWRRDDGTWEVLLVYGVAGERHSASWSYDPPRRLVQAVDDEARSLIGESEDVSAPEPSFPFVPRIARLPRERPERPERGPHAVEPETEELPATAEQGGRDSLTSLLEAVPSFRGDMVVPERPTAERPLEEPEQEQEAEEPPAPAASAGSAYADVLMPRAVAAHRDRLIGSTDRQAEADGVRPGRRAAVPSWDEIVFGTRRKNKE
>NZ_CP016824.1|WP_067416230.1|5687932_5689117_+|hypothetical-protein
MRETTQVKEVGTRSGEEPQEEAKRIDLSVPQVAGSAVAAVAGAVAASQLGVYGTVIGAGVMSVVATTGGSVFQHLFRRTGEQIRDVAHVRPKGEPGPDVPDTFRADPEPDPLTDPAPGRLASADPATAHTVPGDPPAPVEATQLLGRIDPAAPRPADAEATQLLGQADPEATQLLSQADPGATKLLGQAGPDATRALRVPAADPAEADQATRLLRAVPEPSGPETGEFGEATTHQARTGRWKRPLISAAAVFVLAMGGITGWELVSGHALSGDSGPTISHLTGNRSQPSGDQEEEKAPAPEETPSGEAPSDGGSGTPSTQDPEDGTSSTGTPEEGTSPAPTRPGQQPGTPDDSTGDRSPTPTPTPSTGEPEQPTGQPSGGVPSGAAPEEGVPAG
>NZ_CP016824.1|WP_067416233.1|5689136_5690486_-|FAD-binding-protein
MDEQQTQGSTRTASPVRTRNGTWRNWAGTVAARPARETVPASAAELAGAVRDAAARGMRVKAVGTGHSFTAAAATDGLLIRPDLLTGIQIDHEAGTVTVAAGTPLKRLNVALAREGLSLTNMGDIMEQTVAGATSTGTHGTGRASASLSAQITALELVTADGSLLSCSREQNPELFAAARIGLGALGVITSLTFAVEPVFLLRAREEPMGFDQVTAEFDQLVAENEHFEFYWFPHTGNCSTKRNNRTPGPAAPVGRLSGWFEDEFLSNGVFQAANTLGRAVPATIPSLARLSSRALSARTYTDIPYKVFTSPRRVRFVEMEYAVPREALVPALRELRVMVDRSPLRVSFPVEVRTAPADDIALSTASGRETAYIAVHLYKGTPYQAYFTAAERIFTAHEGRPHWGKIHTRDAEYFAEVYPRFAEFTALRDRLDPDRLFGNDYLRRVLGD
>NZ_CP016824.1|WP_008406647.1|5690412_5691687_-|MFS-transporter
MPSPYRAIFSAPGSRGFSAAGFVGRLPLSMMGIGIVTMISQLTGRYGLAGALSAMVALSAALIGPQISRLVDLHGQRRVLRPATLVALAAVSGLLLSAQFSLPDWTLFLFAAGIGAVPSIGSMVRARWAALYRDQPRQLHTAYSFESVVDEACFIFGPIVSIGLSTTWFPEAGPLLAAVFLAAGVFSLTAQRSTEPVPHPREHHTKGSALRSTGLQVLVGTFVATGAIFGAIDVVTVAFAEEQGHKGAASLVLATYAAGSCLAGVVFGLLHFGGAPARRWLLGVVAMGVSMIPLQLVGNLPFLAVALFVAGLCIAPTMITTMALVEQHVPRAKLTEGMTWVSTGLAVGVALGSSVSGWVIDAAGAKAGYWVPAAAGAAAVLVGFLGYRRLSSPAPQREGPDGRAADAGQHQDGESGTHQERDLA

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Crispr_ID: NZ_CP016824_36

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_36

5688349-5688494

Orphan

Consensus_repeat	Method
CGAGGCCACCCAGCTCCTGGGCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP016824_36

>merge|NZ_CP016824|36|5688349-5688494|CRISPRCasFinder
CGAGGCCACCCAGCTCCTGGGCCGGATCGATCCCGCCGCCCCGCGCCCCGCCGATGCCGAGGCCACCCAGCTCCTGGGCCAGGCCGACCCGGAGGCGACCCAGCTCCTGAGTCAGGCAGACCCCGGGGCGACCAAGCTCCTCGGCC

>NZ_CP016824|36|31|5688349-5688494|CRISPRCasFinder
CGAGGCCACCCAGCTCCTGGGCC	GGATCGATCCCGCCGCCCCGCGCCCCGCCGATGC
CGAGGCCACCCAGCTCCTGGGCC	AGGCCGACCCGGAGGCGACCCAGCTCCTGAGTCAGGCAGACCC
CGGGGCGACCAAGCTCCTCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_003951325.1\|5682645_5683245_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067416233.1\|5689136_5690486_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|281959
NZ_CP016824.1\|WP_079165401.1\|5679246_5679546_-\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|273389
NZ_CP016824.1\|WP_067416227.1\|5686419_5687454_-\|DUF3071-domain-containing-protein	unknown	unknown	gnl\|CDD\|378619
NZ_CP016824.1\|WP_008406633.1\|5698181_5698640_-\|DUF3093-domain-containing-protein	unknown	unknown	gnl\|CDD\|378627
NZ_CP016824.1\|WP_067416222.1\|5684469_5685270_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NZ_CP016824.1\|WP_018469409.1\|5673758_5675150_+\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NZ_CP016824.1\|WP_079165402.1\|5696996_5697932_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378945
NZ_CP016824.1\|WP_003951335.1\|5694362_5695016_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP016824.1\|WP_003951340.1\|5698697_5699282_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP016824.1\|WP_030770684.1\|5683244_5684426_+\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366747
NZ_CP016824.1\|WP_067416219.1\|5679675_5682555_+\|bifunctional-GNAT-family-N-acetyltransferase/acetate--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|131764
NZ_CP016824.1\|WP_067416224.1\|5685515_5686343_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NZ_CP016824.1\|WP_030770700.1\|5692955_5693765_+\|inositol-monophosphatase	unknown	unknown	gnl\|CDD\|238817
NZ_CP016824.1\|WP_003951336.1\|5695021_5696293_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP016824.1\|WP_008406666.1\|5676556_5677243_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP016824.1\|WP_067416236.1\|5691806_5692922_+\|ferrochelatase	unknown	unknown	gnl\|CDD\|234585
NZ_CP016824.1\|WP_003951337.1\|5696687_5696984_+\|DUF4193-domain-containing-protein	unknown	unknown	gnl\|CDD\|379391
NZ_CP016824.1\|WP_018469408.1\|5675561_5676335_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP016824.1\|WP_008406647.1\|5690412_5691687_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067416233.1\|5689136_5690486_-\|FAD-binding-protein	gnl\|CDD\|281959	pfam04030, ALO, D-arabinono-1,4-lactone oxidase. This domain is specific to D-arabinono-1,4-lactone oxidase EC:1.1.3.-, which is involved in the final step of the D-erythroascorbic acid biosynthesis pathway.	8.2747e-115
NZ_CP016824.1\|WP_079165401.1\|5679246_5679546_-\|HPr-family-phosphocarrier-protein	gnl\|CDD\|273389	TIGR01003, Phosphocarrier_protein_HPr, Phosphotransferase System HPr (HPr) Family. The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS].	2.97148e-21
NZ_CP016824.1\|WP_067416227.1\|5686419_5687454_-\|DUF3071-domain-containing-protein	gnl\|CDD\|378619	pfam11268, DUF3071, Protein of unknown function (DUF3071). Some members in this family of proteins are annotated as DNA-binding proteins however this cannot be confirmed. Currently no function is known.	3.01174e-61
NZ_CP016824.1\|WP_008406633.1\|5698181_5698640_-\|DUF3093-domain-containing-protein	gnl\|CDD\|378627	pfam11292, DUF3093, Protein of unknown function (DUF3093). This family of proteins with unknown function appears to be restricted to Actinobacteria. Some members are annotated as alanine rich membrane proteins however this cannot be confirmed.	1.57638e-49
NZ_CP016824.1\|WP_067416222.1\|5684469_5685270_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	4.12901e-30
NZ_CP016824.1\|WP_018469409.1\|5673758_5675150_+\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	5.41846e-60
NZ_CP016824.1\|WP_079165402.1\|5696996_5697932_+\|hypothetical-protein	gnl\|CDD\|378945	pfam12787, EcsC, EcsC protein family. Proteins in this family are related to EcsC from B. subtilis. This protein is found in an operon with EcsA and EcsB which are components of an ABC transport system. The function of this protein is unknown.	0.000133165
NZ_CP016824.1\|WP_003951335.1\|5694362_5695016_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	7.04213e-69
NZ_CP016824.1\|WP_003951340.1\|5698697_5699282_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	1.00993e-11
NZ_CP016824.1\|WP_030770684.1\|5683244_5684426_+\|alkaline-phosphatase-family-protein	gnl\|CDD\|366747	pfam01663, Phosphodiest, Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.	9.86342e-40
NZ_CP016824.1\|WP_067416219.1\|5679675_5682555_+\|bifunctional-GNAT-family-N-acetyltransferase/acetate--CoA-ligase-family-protein	gnl\|CDD\|131764	TIGR02717, Uncharacterized_protein_MJ0590, acetyl coenzyme A synthetase (ADP forming), alpha domain. Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.	3.74599e-105
NZ_CP016824.1\|WP_067416224.1\|5685515_5686343_+\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	1.31086e-81
NZ_CP016824.1\|WP_030770700.1\|5692955_5693765_+\|inositol-monophosphatase	gnl\|CDD\|238817	cd01639, IMPase, IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled into inositol lipids; in eukaryotes IMPase plays a vital role in intracellular signaling. IMPase is one of the proposed targets of Li+ therapy in manic-depressive illness. This family contains some bacterial members of the inositol monophosphatase family classified as SuhB-like. E. coli SuhB has been suggested to participate in posstranscriptional control of gene expression, and its inositol monophosphatase activity doesn't appear to be sufficient for its cellular function. It has been proposed, that SuhB plays a role in the biosynthesis of phosphatidylinositol in mycobacteria.	3.32384e-99
NZ_CP016824.1\|WP_003951336.1\|5695021_5696293_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.86374e-51
NZ_CP016824.1\|WP_008406666.1\|5676556_5677243_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	4.24177e-41
NZ_CP016824.1\|WP_067416236.1\|5691806_5692922_+\|ferrochelatase	gnl\|CDD\|234585	PRK00035, hemH, ferrochelatase; Reviewed.	4.7312e-129
NZ_CP016824.1\|WP_003951337.1\|5696687_5696984_+\|DUF4193-domain-containing-protein	gnl\|CDD\|379391	pfam13834, DUF4193, Domain of unknown function (DUF4193). This domain of unknown function contains four conserved cysteines and a conserved histidine, including a CXXXXH motif.	1.90861e-60
NZ_CP016824.1\|WP_018469408.1\|5675561_5676335_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	4.89112e-36
NZ_CP016824.1\|WP_008406647.1\|5690412_5691687_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.43622e-19

>NZ_CP016824.1|WP_067416227.1|5686419_5687454_-|DUF3071-domain-containing-protein
MPELRVVAVSNDGTRLVLKAADSTEYTLPIDERLRAAVRGDRPRLGQIEIEVESHLRPRDIQARIRAGASAEEVASLAGIPVDRVRRFEGPVLAERAFMAERARKTPVRRPGENTGPQLGEAVRERLLLRGADRDTVQWDSWRRDDGTWEVLLVYGVAGERHSASWSYDPPRRLVQAVDDEARSLIGESEDVSAPEPSFPFVPRIARLPRERPERPERGPHAVEPETEELPATAEQGGRDSLTSLLEAVPSFRGDMVVPERPTAERPLEEPEQEQEAEEPPAPAASAGSAYADVLMPRAVAAHRDRLIGSTDRQAEADGVRPGRRAAVPSWDEIVFGTRRKNKE
>NZ_CP016824.1|WP_067416224.1|5685515_5686343_+|sulfurtransferase
MNAIISATALAGELQGPRPPVLLDVRWQLGGPDQRPAYLAGHLPGAVHVDLDGELAGGPGKGGRHPLPDVEAFGAAMRAAGVDAGRPVVTYDGGQGWAAARAWWLLRWAGHPEVRVLDGGLAAWDGPLEEGEVTPEPGDFTPEPGRLELLDADGAAALAASGVLLDARAAERYRGDVEPIDRVGGHIPGAVAAPTTENTGEDGRLLPAAELADRFAALGANPGRKVGVYCGSGVSGAHEVLALAVAGVDAALYVGSWSDWSADPDRPVATGPQPG
>NZ_CP016824.1|WP_067416222.1|5684469_5685270_-|VOC-family-protein
MSVVRGQTVDQRTERPVPGTPCWVSLMADDLVASQEFYGRLFGWEFRPGPEQLGPYARALLDGRVVAGIGRMPEGQSLPVAWTPYLAADDVDETAGTVRHCGGTVGVGPLDAEEAGRMALTADPSGATFGIWQGREHRGAAVEGVPGSVLWNELVTRETAGVLPFYRAAFGFEAEREEAAEDAATLLLDGRPVASVLGVGQALGELGAAHWHTHFAVEDPDETVNRVIELGGRVQRPPRDGSHGRTATVADPWGAVFTVARPDTRA
>NZ_CP016824.1|WP_030770684.1|5683244_5684426_+|alkaline-phosphatase-family-protein
MPSSAWPEPLPLASAPVPAYGSGSLADLLPTLAAGSGVPGMTATLTELPPADRNCVFLIDGLGWHQLLAHPAEAPFLSSLIPTSRGGTGQPLTAGFPATTATSLASVGTGRTPGEHGLPGYTALNPDSGELMNQLRWKPWTDPHAWQPHPTVFSLADAAGVHTAQVSAPGFHHTPLTQVALSGGTFHGRLSGEERMDLAAAQLAAGDRALVYTYYSEVDGKGHRFGVDSDAWRGQLMYVDGLARRLAEQLPPRSALYITADHGMVDIPFDDRHRFDVDEDWELNAGIRLLGGEGRARHLYAVPGAARDVRTVWREVLGEQCWVAGRDEAIEAGWFGPHVEKRVRDRLGDVIVAARDDVAITATRREPNESALTGMHGSMTPAEQLVPLLEVRT
>NZ_CP016824.1|WP_003951325.1|5682645_5683245_+|hypothetical-protein
MAKTGTTTQGLRAAIERSGYYPALVAEAVEAAVGGEPVASYLVHQETTFDANEVRRHVTVLVLTPTRFIVSHTDEQAADSGSPTALATTSTESVKTGRISSVVLSRVVANPESYTPGTLPREVVLTIGWGAVSRIDLEPAACGDPNCEADHGYTGSSTADDLSLRVSEAGDGPDTVRQALAFAQALSEATAATATPAGR
>NZ_CP016824.1|WP_067416219.1|5679675_5682555_+|bifunctional-GNAT-family-N-acetyltransferase/acetate--CoA-ligase-family-protein
MDTPSDQHAYPAHWEADVVLRDGGTARIRPITADDADRLVSFYEQVSDESKYYRFFAPYPRLSAKDVRRFTHHDHVDRVGLAVTIGGEFIATVRYDRIDDRGMPASAPADEAEVAFLVQDAHQGRGVASALLEHIAAVARERGIRRFTAEVLPANTKMIKVFTDAGYQQKRSFEDGVVRLEFGLEPTDRSLAVQHAREQRAEARSVQRLLAPGSVAVVGVGRTLGGVGRSILRNIREAGFTGPVHAVNQGFPDTGDTVEGVRAHRSVRDIAEPVDLAVIAVPAERVPEAVAECGEHGVQGLVVISAGYAEQGPEGRERQRALIRQARSYGMRVIGPNAFGVINTTPETRLNASLAPELPVPGRVGLFTQSGAIGIALLSALHRDGGGADGVPNPTGVSTFVSAGNRADVSGNDVMQYWYDDPHTDVALMYLETIGNPRKFTRLARRTAAAKPLVVVQGARHSGITPTGHPAPVTRLPYATVSALLRQAGVIRVDTVTELVDVGLLLAGQPLPAGPRVAILGNSESLGLLSYDACLSQGLRPLPPRDLTTDATPEDFRAALAAALADDGCDAVVVTAIPWVGADGVPERPDGEALGAALRTAHATAPDKPVVVVHVELGGLAEALSAAAGTGPGSPATQRGPAPSPAAPDSAAPAPDEAPPVPRTRRIPAYPAAERAVRALGEAVRYAQWRREAQRPGGVPEYESIDERGAAADITRLLAAAAPGEEGAAPRAHTLGAEDTRALLARYGIEVRPTLPAPDPDTAVRAAAELGYPVALKTTAPHLRHRADLGGVRLDLADEAQLRQAYAELTGLFGTPAELRPVVQPMAPRGVDTVVRTVIDPAVGAVLTFGLAGAPSELLGDTAHRLVPVTDRDATAMVRSIRTAPLLFGWRGSAPVDTPALEELLQRVSRLVDDHPEVVDVQLEPVVVAPRGVSVLGASVRLAPPPPRDDLGPRTLPAY
>NZ_CP016824.1|WP_079165401.1|5679246_5679546_-|HPr-family-phosphocarrier-protein
MKGSFNMAERRVNVGWAEGLHARPASIFVRAATASGIPVTIAKPDTAPVNAASMLAVLGLGVQGGEEIVLSADADGAEATLERLARLVAEGLDELPETV
>NZ_CP016824.1|WP_008406666.1|5676556_5677243_+|GntR-family-transcriptional-regulator
MGIPAQSVCTAIREDIVSGVHERGSRLTEEQLARRYGVSRVPVREALRTLEAEGFVVTRRHAGACVAEPTEQEAADLLEIRMLLEPLGAARAARRRTEAHLKVLRGLVRLGQERARLGEGEDLRSLGAWFHETLAQASGSPGLTALLTQLRQKVTWMYAVDPPAAPAESWAEHGAIVDAVARGDAERARALTAQHAERATAVHRLRFGSRTTGVRTSQHAVNIPGGRN
>NZ_CP016824.1|WP_018469408.1|5675561_5676335_+|M23-family-metallopeptidase
MAFTRPTGKHRRPHRRAARTGAGLAGVAALTTTGVVSTLASPAAAAEAPAHTGFTEAIVIGHSLADRIDDQAAAQRLAAEDAAAEQAAVEAARLQAAEAKRKAEKKRAEKVRAARAAERERLNRYVLPVEGSYVSTGYQTGGSLWSSGSHSGVDFHAPAGSAVRAVGAGTVVETGWGGAYGNEVVIQMHDGTYTQYGHLASATVSVGQTVTPGQQIAVSGSTGNSTGPHLHFEARSGADYGTDMDPVAYLRGHGVDV
>NZ_CP016824.1|WP_018469409.1|5673758_5675150_+|insulinase-family-protein
MSDVITPAMDLHPQPAGGAPRPWAFPAPERTTLDNGLTVLTCHRPGQQVVAVEVLLDSPLDTEPEGLDGLATIMARAFSEGTDRDSAEEFAAELERCGATLDAFADHPGVRLSLEVPVSRLEKALGLLADALRAPAFAEAEIERLVRNRLDEIPHEQANPARRAAKELSRQLFPAGSRVSRPRQGTEETVERIDAAAVRAFYERHVRPATATAVVVGDLEGTDLGALLAGSLGAWQGDAGQPNPVPPVTADDTGRVVIVDRPGAVQTQLLIGRVGPDRHDRVWPAQVLGTYSLGGTLTSRLDRVLREEKGYTYGVRSFAQVLRSTPEGTGAAMLAISGSVDTESTGPALDDLWKVLRTLAAEGLTDAELDTAVQNLVGVAPLKYETAAAVASTLADQVEQHLPDDFQARLYRMMTETGATEATAAVVSAFPADRLVTVLVGDASRIAEPVRALGIGEVSVVTG
>NZ_CP016824.1|WP_067416233.1|5689136_5690486_-|FAD-binding-protein
MDEQQTQGSTRTASPVRTRNGTWRNWAGTVAARPARETVPASAAELAGAVRDAAARGMRVKAVGTGHSFTAAAATDGLLIRPDLLTGIQIDHEAGTVTVAAGTPLKRLNVALAREGLSLTNMGDIMEQTVAGATSTGTHGTGRASASLSAQITALELVTADGSLLSCSREQNPELFAAARIGLGALGVITSLTFAVEPVFLLRAREEPMGFDQVTAEFDQLVAENEHFEFYWFPHTGNCSTKRNNRTPGPAAPVGRLSGWFEDEFLSNGVFQAANTLGRAVPATIPSLARLSSRALSARTYTDIPYKVFTSPRRVRFVEMEYAVPREALVPALRELRVMVDRSPLRVSFPVEVRTAPADDIALSTASGRETAYIAVHLYKGTPYQAYFTAAERIFTAHEGRPHWGKIHTRDAEYFAEVYPRFAEFTALRDRLDPDRLFGNDYLRRVLGD
>NZ_CP016824.1|WP_008406647.1|5690412_5691687_-|MFS-transporter
MPSPYRAIFSAPGSRGFSAAGFVGRLPLSMMGIGIVTMISQLTGRYGLAGALSAMVALSAALIGPQISRLVDLHGQRRVLRPATLVALAAVSGLLLSAQFSLPDWTLFLFAAGIGAVPSIGSMVRARWAALYRDQPRQLHTAYSFESVVDEACFIFGPIVSIGLSTTWFPEAGPLLAAVFLAAGVFSLTAQRSTEPVPHPREHHTKGSALRSTGLQVLVGTFVATGAIFGAIDVVTVAFAEEQGHKGAASLVLATYAAGSCLAGVVFGLLHFGGAPARRWLLGVVAMGVSMIPLQLVGNLPFLAVALFVAGLCIAPTMITTMALVEQHVPRAKLTEGMTWVSTGLAVGVALGSSVSGWVIDAAGAKAGYWVPAAAGAAAVLVGFLGYRRLSSPAPQREGPDGRAADAGQHQDGESGTHQERDLA
>NZ_CP016824.1|WP_067416236.1|5691806_5692922_+|ferrochelatase
MSDVRDATPYDALLLLSFGGPEGPDDVVPFLRNVTHGRGIPEERLKEVGQHYYLFDGISPINAQNRDLLAALRADFAEHGVELPVFWGNRNWSPYLPDTLREMAKEGHRRIAVLATSAYASYSGCRQYRENLADALAALQTEGLPVPRVDKLRHYFNHPGFLEPMIDGVLASLADLPEEVRDGAEIAFTTHSIPDAAADTSGPREVHGDGGAYVAQHLDTARAIADAVRERTGVDRPWSLVYQSRSGSPHIPWLEPDICDHLEERHAAGAPAVVMAPIGFVSDHMEVRYDLDTEATAKAAELGLPVRRSATVGADPRFAAAVRDLLLERAATERGEHPARCALGALGPSHDVCPVGCCPARSPRPAAAGMD
>NZ_CP016824.1|WP_030770700.1|5692955_5693765_+|inositol-monophosphatase
MTDPNTGLLALALEAARRAGDFLRDGRPADLAVAATKTSAIDVVTEMDIASEKMITGFLADRRPEDGFLGEEGASTEGTSGVRWIIDPLDGTVNYLYGRPAWAVSIAAERDGVTVVGVVHAPMRGETCRAVLGGGAHLNDTPIQVNTAPSLDRALVGTGFGYLAGRKAHQAAVAARIIPEVRDIRRGGSAAIDLCDVATGRLDAYYERGLNPWDYAAGELIAREAGALTGGRPGAPASTELTVAAPPGLFEPLQERLEEYGAWHDGTLA
>NZ_CP016824.1|WP_003951335.1|5694362_5695016_+|response-regulator-transcription-factor
MRVLVVEDEQLLADAVATGLRREAMAVDVVYDGAAALERVGVNDYDVIVLDRDLPLVHGDDVCRRVVELQMPTRVLMLTASGDVSDRVEGLEIGADDYLPKPFAFTELIARVRALGRRTSVPLPPVLERAGIKLDPNRREVFRDGREIQLAPKEFAVLEVLLRSEGAVVSAEQLLEKAWDENTDPFTNVVRVTVMTLRRKLGEPAVIVTVPGSGYRI
>NZ_CP016824.1|WP_003951336.1|5695021_5696293_+|HAMP-domain-containing-histidine-kinase
MAASPAPRPAPPKPTSAPPRPTWDPRRPPQQAWLRPTIRIRLTLLYGGMFLIAGILLLSIIYLLAAQAVHVGNELPFQVTSGTFTIYSDACPALSGRRFTSSGAFNDAMKLCIDHQRQQALDDLLSRSLLALVGLSVIAFAFGYAMAGRVLAPLGRITRTARSVAGSDLSRRIELDGPDDELKELADTFDDMLDRLERAFTAQQRFVANASHELRTPLAINRTLLEVQLSDPGAPPELQQLGKTLLATNERSEQLVEGLLLLARSDNQIVERKPVDLGEVATRAVEQVRGEAEQREVELRADIAEAVVQGNGVLLERIALNLTQNAVRYNLPPGEGGWVEVSTELQHGQAVLVVTNTGPVVPAYEIDQLFEPFRRLRTERTGSDKGVGLGLSIVRSVTRAHGGRITAEPREGGGLVMRVTLPL
>NZ_CP016824.1|WP_003951337.1|5696687_5696984_+|DUF4193-domain-containing-protein
MATDYDTPRKTDDDLNEDSIEELKARRNDKSTSTVDVDEFEAAEGLELPGADLSNEELAVRVLPKQQDEFTCMSCFLVHHRSQLAREKNGQPICRDCD
>NZ_CP016824.1|WP_079165402.1|5696996_5697932_+|hypothetical-protein
MTGTTPPRKFPFLKRRGGGAPSPAESDGERGLGASLEAADATDGAPGPHSGGTGTGEGPAATEPATPAPGRVAAVRDGLLRQGRNAKAGLGVLADRVIEIAPRIPVRDLHTLRAQFPGLGPEQLADKLISGAAHGTSTVGASVGAAAMLPVPPAMPAELAAEITAVAAIELKLIAELHEVYGQRPEGGATRRATAYLTSWTNERGIDVVRPLTITAALSGPLKRDLRQQITKRMIRNLPNLVPFLVGAAVGAVMNRRDTRKLAERVRQDLRAAQVPWDQLTSLPPLDRPELPPATLPHALPPAPRDDNRPT
>NZ_CP016824.1|WP_008406633.1|5698181_5698640_-|DUF3093-domain-containing-protein
MHPNTPQYAERLTAPRAWWALVAIAGLTSGLIVMPLGVLAMLIGLVVGAAAGAAGLSTYGSAQIRVVGDALVAGDARIPLSALGAAEPLDAEETVAWRSHKADPRAFMLLRSYIPTAVRVEVTDPADPTPYLYLSTRDPERLAAALSPVREG
>NZ_CP016824.1|WP_003951340.1|5698697_5699282_+|PaaI-family-thioesterase
MSGRTPALTPPDSALAPVRHPDAPAPGEPIGTHYEHCFGCGGEQPHGLHLAAKAGEGVSVTAEFLVRPEHQGAPGLAHGGLLATALDDTLGALNWLLRVISVTGRLETDYLRPVPVGTVLHLSAEVTAVDGRKIYATAEGRLNAPDGPVAVRADALFVEVKVEHFTDNGRPEEIQAAMDDPDQIRRVRAFEVNP

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Crispr_ID: NZ_CP016824_37

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_37

6750736-6750838

Orphan

Consensus_repeat	Method
TGGCCTCAGGCGCCGGCCGGGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_37

>merge|NZ_CP016824|37|6750736-6750838|CRISPRCasFinder
TGGCCTCAGGCGCCGGCCGGGCTGTTGTGTGTGCCGGGCTTCGCCCCGACCTACCGGCCGTGCCCCTGCGGGTCACCGATTGGCCTCAAGCGCCGGCCGGGCT

>NZ_CP016824|37|32|6750736-6750838|CRISPRCasFinder
TGGCCTCAGGCGCCGGCCGGGCT	GTTGTGTGTGCCGGGCTTCGCCCCGACCTACCGGCCGTGCCCCTGCGGGTCACCGAT
TGGCCTCAAGCGCCGGCCGGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067417466.1\|6763479_6765909_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|163057
NZ_CP016824.1\|WP_003952271.1\|6749441_6750665_+\|geranylgeranyl-reductase-family-protein	unknown	unknown	gnl\|CDD\|273936
NZ_CP016824.1\|WP_067417442.1\|6742055_6743357_+\|aldolase	unknown	unknown	gnl\|CDD\|225184
NZ_CP016824.1\|WP_010640353.1\|6747913_6749281_-\|dipeptidase	unknown	unknown	gnl\|CDD\|236127
NZ_CP016824.1\|WP_067417463.1\|6761071_6763510_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_079165422.1\|6739244_6739829_+\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|214900
NZ_CP016824.1\|WP_003952264.1\|6740909_6741872_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NZ_CP016824.1\|WP_067417461.1\|6758204_6758525_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067417457.1\|6756094_6757333_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP016824.1\|WP_018468779.1\|6744678_6745650_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP016824.1\|WP_067417448.1\|6746885_6747866_+\|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|107205
NZ_CP016824.1\|WP_003952263.1\|6740030_6740816_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|238847
NZ_CP016824.1\|WP_067417460.1\|6757421_6757958_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP016824.1\|WP_008416247.1\|6745852_6746875_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239217
NZ_CP016824.1\|WP_067417451.1\|6752988_6753648_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067417456.1\|6755383_6756043_+\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	unknown	unknown	gnl\|CDD\|372627
NZ_CP016824.1\|WP_067417453.1\|6754034_6755252_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NZ_CP016824.1\|WP_003952280.1\|6758849_6759986_+\|PLP-dependent-cysteine-synthase-family-protein	unknown	unknown	gnl\|CDD\|223110
NZ_CP016824.1\|WP_067417445.1\|6743381_6744422_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP016824.1\|WP_008416220.1\|6759997_6760804_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067417466.1\|6763479_6765909_-\|AAA-family-ATPase	gnl\|CDD\|163057	TIGR02881, Stage_V_sporulation_protein_K, stage V sporulation protein K. Members of this protein family are the stage V sporulation protein K (SpoVK), a close homolog of the Rubisco expression protein CbbX (TIGR02880) and a members of the ATPase family associated with various cellular activities (pfam00004). Members are strictly limited to bacterial endospore-forming species, but are not universal in this group and are missing from the Clostridium group. [Cellular processes, Sporulation and germination].	2.75649e-89
NZ_CP016824.1\|WP_003952271.1\|6749441_6750665_+\|geranylgeranyl-reductase-family-protein	gnl\|CDD\|273936	TIGR02032, Uncharacterized_protein_MJ1520, geranylgeranyl reductase family. This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll].	9.56591e-91
NZ_CP016824.1\|WP_067417442.1\|6742055_6743357_+\|aldolase	gnl\|CDD\|225184	COG2301, CitE, Citrate lyase beta subunit [Carbohydrate transport and metabolism].	0.00268819
NZ_CP016824.1\|WP_010640353.1\|6747913_6749281_-\|dipeptidase	gnl\|CDD\|236127	PRK07907, PRK07907, hypothetical protein; Provisional.	0
NZ_CP016824.1\|WP_079165422.1\|6739244_6739829_+\|flavin-reductase-family-protein	gnl\|CDD\|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	1.08692e-43
NZ_CP016824.1\|WP_003952264.1\|6740909_6741872_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	2.39479e-103
NZ_CP016824.1\|WP_067417457.1\|6756094_6757333_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	3.519e-37
NZ_CP016824.1\|WP_018468779.1\|6744678_6745650_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	9.91523e-63
NZ_CP016824.1\|WP_067417448.1\|6746885_6747866_+\|pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|107205	cd01562, Thr-dehyd, Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.	8.5126e-73
NZ_CP016824.1\|WP_003952263.1\|6740030_6740816_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	4.84728e-79
NZ_CP016824.1\|WP_067417460.1\|6757421_6757958_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	1.05766e-16
NZ_CP016824.1\|WP_008416247.1\|6745852_6746875_+\|NUDIX-hydrolase	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	2.4451e-17
NZ_CP016824.1\|WP_067417456.1\|6755383_6756043_+\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	gnl\|CDD\|372627	pfam13532, 2OG-FeII_Oxy_2, 2OG-Fe(II) oxygenase superfamily.	1.44344e-56
NZ_CP016824.1\|WP_067417453.1\|6754034_6755252_-\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.6854e-81
NZ_CP016824.1\|WP_003952280.1\|6758849_6759986_+\|PLP-dependent-cysteine-synthase-family-protein	gnl\|CDD\|223110	COG0031, CysK, Cysteine synthase [Amino acid transport and metabolism].	1.35791e-94
NZ_CP016824.1\|WP_067417445.1\|6743381_6744422_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.74071e-103
NZ_CP016824.1\|WP_008416220.1\|6759997_6760804_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.48224e-77

>NZ_CP016824.1|WP_003952271.1|6749441_6750665_+|geranylgeranyl-reductase-family-protein
MSSENSAGDDRQVWDVVVVGAGPAGASAAYAAAVAGRRVLLLEKAELPRYKTCGGGIIGPSRDNLPPGFDLPLQDRVRAVTFSLDGRFARTRRSRQMLFGLVNRPEFDQRLVEAAQKAGAELRTGATVLRVEQHGPAVPDRRTVAVFVQTSGPGGEREEETLLARAVVGADGSASRIGAHVGVKLDQVDLGLEAEIPVPETVAEDWQGRVLIDWGPMPGSYGWVFPKGDTLTVGVISARGEGAATKRYLTDFIARLGLAGFEPSLSSGHLTRCRTDDSPLSRGRVVVCGDAAGLLEPWTREGISYALRSGRLAGEWALRIAEAHDAVDARRQALNYAFAIKAGLGVEMAVGRRLHQLFARRPGVLHAALTGVRPAWNAFAKVTRGGTTLGELIRNHPVAARMLAGRE
>NZ_CP016824.1|WP_010640353.1|6747913_6749281_-|dipeptidase
MPSTPIAETVAALMPRAKEELTELVAFRSVADEEQFPRAECEAAADWVADALRGEGFQDVALLDTPDGTRSVYGYLPGPEGARTVLLYAHYDVQPPLDEAAWVTPPFALTERDGRWYGRGAADCKGGFIMHLLALRALKAAGGVPVHVKVIAEGSEEQGTGGLERYAEAHPELLRSDAIVIGDSGNFRVGVPTVTATLRGMAMARLTVDTLAGNLHSGQFGGAAPDALAALIRVLDSLRDEDGSTTVEGLANDAVWPGLQYPEEEFRKDAKVLDGVRLTGSGTVADRIWARPSVTVIGIDCPPVVGATPSVQASARAQISLRVPPGVDAAEAMKLLAAHLERHVPWGARARVEQIGEGQPFSADTSSPAYQAMAEAMAAAYPGEQMQEAGQGGSIPLTNTLGSLYPEAEILLIGLSEPEAQIHAPNESVSPEELERLAVTEAYFLQNYARTATAG
>NZ_CP016824.1|WP_067417448.1|6746885_6747866_+|pyridoxal-phosphate-dependent-enzyme
MPRTRLDTGRILAARQLIDPVFLDTPFYRCEALEPRLGCAVNIKLETANPVRSFKGRGTEVVASLLADAGRRAVVCASAGNLGQALAWSGRTRGVDVTVVASRSATTAKLDRIRALGATLELVDGDHESARERAASLARNAGIRLLEDSLDLETCEGAGTIGWELVNSRLPFDTVVLALGGGALATGVGHVLNELTPHVEVVCVQALGAPALAYSWRRRRVVTTASTDTIADGVAGRFPIPAVLEDLLLVADDVVLVREESIVAGMRLLLHHAGLVVEPSAALGLAAVIEDRDRFAGRSVATVVCGSNVDMAAHRRWTGGAQAREC
>NZ_CP016824.1|WP_008416247.1|6745852_6746875_+|NUDIX-hydrolase
MIIWVNGAFGADQTAVAKELTELLPRSVLFDPETVEEQLVRLLPPKRLAEVADLQELPMWRRLVVDTAAALFAETGGDVVVPGSLLRQEYRDEIFGALAARRITVSHVLVDPGETILRARSAETPTGTRTASRPPHDPAAYGAVLSAWLAADAHVLDTRGLSPAQSAQRIADLLHQGGARTCDIVQTPEPTAETVASGVLLFDERERVLLVDPTYKPGWEFPGGIVEPGEAPAAAGVREVAEETGLSLDQADLRLLVMDWEPPMPPGFGGLRLLFDGGRLDSRDATSMLLPGPELRACRFVGLDEAEGLLPPVRFERLRWAVAARGTGGPLYLERGVPLR
>NZ_CP016824.1|WP_018468779.1|6744678_6745650_+|ROK-family-protein
MTRTELTAALDIGGTKIAAALVDREGRIVRRAQRPTPADQDGERVVAAVHAALGELAAHPDWERAGALGIGSAGPVDASAGTVSPVNIPGWRDFPLVERVREVVGARPVRLIGDGVAVAAAEHWQGAARGYDDALCMVVSTGVGGGLVLGGRLYAGPTGNAGHIGHISVDFDGDLCPCGGRGCVERIASGPHIAARALAEGWRPGPDGDTSAAAVAAAARAGDPVARASFARAGRALAAGIAATATLTEIRIAVIGGGVAAAGDVLFAPLRRALDQYATLAFVRGLTVVPARTGTDAGLIGAAAAVLREDGWGGSAAGRRQAA
>NZ_CP016824.1|WP_067417445.1|6743381_6744422_-|LacI-family-transcriptional-regulator
MAQTARRPAPRYGNRPTMKDVAARAGVGLKTVSRVVNSEPGVTVETERRVREAIDALGFRRNDSARVLRKGRTASVGLILEDLADPFYGPLSRAVEEVARAHGALLINGSSAEDPERERELALALCARRVDGLVVIPAGEDHRYLEPEIAAGVATVFVDRPAGGIEADAVLSDNAGGAREGVAHLLAHGHRRIGFIGDLPHIHTAAERLRGYREAMAEAGAPVDERWVSMGPTGAERVAAEAARLLSGPEPVTALFAGNNRVTVTALRVLADREEPVALVGFDDIELGDLLRPGVTVVAQDAALIGRTAADLLFGRLEGEPARPRQVKLPTRLIVRGSGELPPAGR
>NZ_CP016824.1|WP_067417442.1|6742055_6743357_+|aldolase
MGQHEQAATSFGSGLTEEIGALLAPVDAELERRYPGDPGTRQPVHTVYVPADAFGPATLRDWGDEALDALDAHAPDAGSFAAVLGLAGDLAAPVYDRVRAKLTREPVEDLRIDFEDGYGPRPDAEEDEAAVRAARTVAAAYADGSAAPYMGIRMKCMEAAVRDRGIRTLDLFLTTLLDSGPLPSGLVLTLPKVTYAAQVTAMARLLEAFEKTHGLDAGRLGFEIQIETSQSILGPDGTATVARMIDAAEGRATGLHYGTFDYSACLGVAAAHQASDHPAADHAKAVMQVAAAGTGVRVSDGSTNVLPVGPTPKVHDAWRLHYGLTRRALARAYYQGWDMHPAHIPTRYAAVFAFYRESFEQAAARLAAYANRTGGDVMDEPATAKALAAHLLRGLECGALDNGEVARLSGLTRADLETYARPRRAELGAERGA
>NZ_CP016824.1|WP_003952264.1|6740909_6741872_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MAEVLVYVDHVDGAVRKPTLELLTLARRIGEPVAVALGAGAADTASALAEHGAVKVLTADAPEFADYLVVPKVDALQAAYEAVSPAAVLLPSSAEAKEIAARLALRIGSGIITDAVDLEAGDEGPVATQSVFAAAFTTKSRVSKGTPVITVKPNSAPVEAAPAAGAVEALSVSFSEKATGTKVVSRTPRESTGRPELTEAAIVVSGGRGVNGAENFAIIEALADSLGAAVGASRAAVDAGWYPHTSQVGQTGKSVSPQLYIANGISGAIQHRAGMQTSKTIVAVNKDEEAPIFELVDYGVVGDLFEVVPQLTEEVKARKG
>NZ_CP016824.1|WP_003952263.1|6740030_6740816_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MSLRIVVCVKYVPDATGDRHFADDLTLDRDDVDGLLSELDEYAVEQALQIADEADDAEITVLTVGPDDAKDALRKALSMGADKAVHVEDDDLHGTDVMGTSLVLAKAIEKTGYDLVICGMASTDGVMGVLPAVLAERLGVPQVTLLSEVSVEDGTVKGRRDGDTATEQLEAALPAVVSVTDQSGEARYPSFKGIMAAKKKPVESLDLEDLDIEADEVGLENAWTKVDSATERPARTAGTIVKDEGEGGKQLAAFLAERKFV
>NZ_CP016824.1|WP_079165422.1|6739244_6739829_+|flavin-reductase-family-protein
MPPAENRAAPRLPSPSSPDPGSPHGGTDGSADARAPLDGSPELLRAAFRRHPAGVAVITARGSRLAGFTATSLTSVSAEPPLVSFGVGTASGSWPVIAEAEHVGVHLLGEHQRELAGLFPRSGADRFAPPTRWREGPEGVPLLESVPVWLVCRVVARVPAGDHRVVVAEVVAGDPAGPGRPLVHHDGCYNALRD
>NZ_CP016824.1|WP_067417451.1|6752988_6753648_+|hypothetical-protein
MRITTIGATATAVAVLASPITSTPAPTPATVPAVPAASVVSKPAKTASVHGEARISYIESIHDDIRFTIHAEQTPFTRPMPPTAPEGLSTDARGTLKFSHSRGEVTGWAEATVDCLVTSGRTATLTAVVTKSNVEEPGARLGISVQQGGKGEPDRLGFSWGVVNVDPENIDENGQLVRPQAGSCMAPAPFTTVIKGGYKVIHAEITKSPTQPEPAPHHS
>NZ_CP016824.1|WP_067417453.1|6754034_6755252_-|MFS-transporter
MPLINKPGSTPRSASSPSSSRSSLSVLRRALTVFFALDGFVFAGWVVRIPAIKEQTQASASDLGLALLGVSAGAVVTMTLTGRLCRRYGSRPVTVAGALLLAPGVTLPPLTHSALALGLVLLVFGAAYGGINVAMNSAAVDVVAALGRPVMPTFHAAFSLGGMVGAGLGGIVAGYLSPTWHLLLLGVVTLLVTLATAPVLLRQPMPAPVRPEPAEGASAAPLAGRARTLVAVFGLIAFCTAYGEGALADWGALHLQEDLAARPGVAAAGYAVFALAMTVGRLSGTALLERVGRTATLVGGGIVAGVGMLFGALAPSLWVALLGFAVTGLGLANLFPVAIERAGALTGPSGVAAASTLGYGGMLLGPPAIGFMAEWGSLPLALVSVAVLAGVAAFVGWGARGAARA
>NZ_CP016824.1|WP_067417456.1|6755383_6756043_+|alpha-ketoglutarate-dependent-dioxygenase-AlkB
MAALIPRSRTTPAPGAVHVPEWLPEERQRELVEACRGWARGPVPMRRTELPGGGVMSVQSVSLGWHWSPYRYTRRAGDVNGAPVAPLPEWLVELGRRAVADAYQDEAAGGAYRPDVALVNFYGPGATMGMHQDKDERSDAPVVSLSVGDACLFRLGNTGGRGRPWQDLRLESGDLLVFGGLSRFAYHGVPKVYPGTAEPSVGPATGRLNLTLRETGLPG
>NZ_CP016824.1|WP_067417457.1|6756094_6757333_+|ROK-family-protein
MNGKSAPRTLGGTPPRTRLERGRGALGPALELVRTGRAPTRAVLTSELGVTRATAGVVAAELATLGLIRVDARPTAEGSQGRPSHRLSVDPEGPVVLAAQVHSDGFRAALVGLGGQIVATTPGCETVGADPAEVIGAVVDAGGGLLAETGRRCVGAGLAVPSAVAEPDGTALNPLHLAWPPGAPVREIFRRCVAGAGVPGPAFAANDVNLAALAEHRHGAGRGARDLLCVATGHGGVGGALVLDGRLHSGSSGLALEVGHLTVDPDGRPCHCGGRGCLDVETDPLAFLAAAGHRPGPQGSLLQQARDLIAARPDDPAVREAVTVLVDRLGFGLAGLVNILNPDRVILGGLHRTLLEADPERLRAVVADRSLWGRSGSVPILSCTLDHNSLVGAAELAWQPVLDDPLAALAVV
>NZ_CP016824.1|WP_067417460.1|6757421_6757958_-|ATP-binding-protein
MISQPTRQCAVELQALPPRIGQVRRIVSAQLRYWHLDPLVDRAALGVTELLTNVHRHAGPDKRCTVRLELLLDRLTVSVRDRDPRLPVVRDATMDATCGRGLALVAAVSECWGVRPWETSGKVVWFTLPAPRPVPAEPGGAALYGATTPGPFPPAALDSALPGLAAGPSAPARSAFAG
>NZ_CP016824.1|WP_067417461.1|6758204_6758525_-|hypothetical-protein
MGKSEFSATGVGIMRRLRSLTRAGQVRVADGRLALLTSCGRVIDSAPAREVRVERPWFGSDDQAVIAFNDTRYRLRLGGPAAAASAPHVSPVRRLREAVGQAGGVG
>NZ_CP016824.1|WP_003952280.1|6758849_6759986_+|PLP-dependent-cysteine-synthase-family-protein
MTTPQHEQAAACPLPTADVDRSDPGYREWLKEAVRKVQADANRSADTHLLRFPLPEEWGVDLYLKDESTHPTGSLKHRLARSLFLYGLCNGWIRPSRPVIEASSGSTAVSEAYFAQLIGVPFIAVMPRTTSPEKCRLIEFHGGRCHFVDDPRTMYEESARLAAETGGHYMDQFTYAERATDWRGNNNIAESIYQQMRRERHPEPAWVVATAGTGGTSATIARYVHYMQYDTRVCVADPENSCFFDGWRLGDPAVHCDSGSRIEGIGRPRMEPSFLPGAIDRMMKVPDAASVATVRMLEGAIGRRAGGSTGTGLWSALRIVAEMRAEGRTGSVVTLLCDPGDRYLDKYYSDTWLAEQGLDITPYARTLDAFLTTGRRPA
>NZ_CP016824.1|WP_008416220.1|6759997_6760804_-|DeoR/GlpR-transcriptional-regulator
MGEQQSLLAEQRRALIADEVRRRGGVRVNELTRRLGVSDMTVRRDLDVLARQGVLEKVHGGAVPPADASAHEPGFEAKSGLEPDAKESIAREAAALVSPGTAIALSGGTTTYALAKRLTGVADLTVVTNSVRVADVFHAAQPGAERQAAVVLTGGVRTPSDSLVGPVADQAIRSLHVDVLFIGVHGIAPEAGLSTPNLAEAETNRCLVRSARRVVVVADHTKWGTVGLSSFATLDEVDTLVTDEGLDEEARAEVAERLRLLVVAGPQG
>NZ_CP016824.1|WP_067417463.1|6761071_6763510_+|hypothetical-protein
MHQDQPAPQPGTPAPDAPPPVPGGPPPGGGIAEDTALELLVHGVGGSTPAEMLDDPCTVRVSGDQTAAVHRRAQDADAEQRPEDYRGKPVPEAYVWSNLTSGNGTRALWLLLLPFMVVNLAHWMRPSTTGRRTAVRLYGLLARLVALSLTVLLTAAACEVALDLVAWQCAGTASCSGERAWLGFLATDAQGSGGWWSQPGRRLALAALVPGALTALLWYLSHRTWRSYESQQPLPAVDRAEQEAEENAPHAALGRPGFWYGRRLGARLRAAHTSAGLLTVGAAVAGPAAEHDRLPGGPALLSTVGSALQAALLVSAVAVVWVVSRRGRAESRLDEHLDRLVRVLPLTALALTLLSLGYAAWSRPGWQSAGRLPGDETFGTLVLAQGVLVVALAATARRLHATTPERRTVLKGLGGPAVAMLACALGGVMSGGVAQRVADWLDNGSTPGAPGGPIPGPPILLSWQASVLPPLLVILLAVLVWYAVRTHRHARREEAQVAADYPGEPLDATRTAKIASARAMAALTDRAPVVVGVVSSVTLLLGAGALLGAWTTGRVPGEAARELPAVVSGAAATAQALGSWLIGFGFLLFVTWGRRAYRDPAARRTIGILWDVGTFWPRAAHPFAPPCYAERSVPDLTWRIASWTRETGGRVVLSGHSQGSVLAAAAAWQLRPSARRRVALLTYGSPLERLYGRWFPAHFGPVALTTLHGEVDCWRNLWRLTDPIGGPVRVGTEGRPEVDRPPLADPLAHGRTAAHPLPAPILGHSDYQADPAFAEERARLLARLEEPAAALPKQLNAAEGQPAQGSAGRSSG
>NZ_CP016824.1|WP_067417466.1|6763479_6765909_-|AAA-family-ATPase
MAQGTVQVTHTGTSRWRRRTGEYASLTAALEAAADGDILTVAPGTYRENLVVDRAVTLLGQEGAAGSVRIAPPEGVPLAVRASAQVQGLHIEGQDAAVPAVLVEDGTPELTGLRIVTRSAAGIEVRGGGRPTVRACTVDNPAGVGIAVVDGGGGIFEECEVIAAGQSGVAVRGGGRPRLDRCRVHHAAGAGLSVTGDHSSLEALGCEIYEINGSGVQIASRAAAVLTDCAVHRVTGNGVTLDTDAVLTLADCRVHDVPENAVDLRSRSVLTLTRSEVARFGRNGLSVWDPGTRVDAHRCEIHDGTGDYPAVWVSDGATAVLEGCRVHDVPDALCVLDRGSRADVVDSDLSQVRNIAVSVSGGATAELDDCRISGAGRGAWFRDHGSGGTLANCTIDAAQTGVIVTKGADPLIERTTVTSPTEAGFYVSAGGRGTFQGCRVTGSEGYGFHIIDGCRSTLRKCRTERCARGGFEFAQAGADGEGAVVEECSSDESTQLGSPAAATAPPAPATQTAGLLGGVPSPRSTTPAAPEAAPEPPPETRPADTVLADLDALVGLASVKREVRALTDMIEVGRRRQEAGLKAASVRRHLVFTGSPGTGKTTVARLYGEILAALGVLDRGHLVEVSRVDLVGEHIGSTAIRTQEAFDRARGGVLFIDEAYALSPEDSGRDFGREAIDTLVKLMEDHREAVVVIVAGYTTEMERFLSVNPGVASRFSRTITFSDYDPDELLRIVEQQADEHEYRLGPGTGEALHKYFTALPKGPAFGNGRTARQTFEAMVERHAGRVAQLSAPGTEELTLLYPEDLPALP

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Crispr_ID: NZ_CP016824_38

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016824_38

7051417-7051506

Orphan

Consensus_repeat	Method
GGAGCATCCCCGCGGGTGCGGGGCCGACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016824_38

>merge|NZ_CP016824|38|7051417-7051506|CRISPRCasFinder
GGAGCATCCCCGCGGGTGCGGGGCCGACATGGTGTGCGCGGAGGCCGCGGGCCGGGTGCGGGGAGCATCCCCGCGGGCGCGGGGCCGACA

>NZ_CP016824|38|33|7051417-7051506|CRISPRCasFinder
GGAGCATCCCCGCGGGTGCGGGGCCGACA	TGGTGTGCGCGGAGGCCGCGGGCCGGGTGCGG
GGAGCATCCCCGCGGGCGCGGGGCCGACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016824.1\|WP_067417816.1\|7042305_7043595_+\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NZ_CP016824.1\|WP_067417822.1\|7046566_7048501_+\|cellulase-family-glycosylhydrolase	unknown	unknown	gnl\|CDD\|226444
NZ_CP016824.1\|WP_143067295.1\|7053008_7054349_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067418358.1\|7055503_7055758_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_079165431.1\|7058606_7060172_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236199
NZ_CP016824.1\|WP_008406812.1\|7044576_7045404_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP016824.1\|WP_067417819.1\|7045400_7046477_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP016824.1\|WP_067417825.1\|7048553_7050890_+\|beta-glucosidase	unknown	unknown	gnl\|CDD\|185053
NZ_CP016824.1\|WP_079165430.1\|7055166_7055505_-\|lasso-peptide-biosynthesis-B2-protein	unknown	unknown	gnl\|CDD\|379206
NZ_CP016824.1\|WP_159393473.1\|7060956_7061847_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367638
NZ_CP016824.1\|WP_018894638.1\|7043627_7044563_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP016824.1\|WP_067417805.1\|7037192_7038500_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340925
NZ_CP016824.1\|WP_067417829.1\|7052158_7052932_-\|transposase	unknown	unknown	gnl\|CDD\|372577
NZ_CP016824.1\|WP_143067296.1\|7054547_7055090_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067417808.1\|7038499_7039297_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP016824.1\|WP_067418361.1\|7055984_7056791_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NZ_CP016824.1\|WP_067417814.1\|7041727_7042129_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016824.1\|WP_067417811.1\|7039293_7041501_+\|2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|349881
NZ_CP016824.1\|WP_008406749.1\|7056823_7057762_-\|daunorubicin/doxorubicin-resistance-ABC-transporter-ATP-binding-protein-DrrA	unknown	unknown	gnl\|CDD\|130256
NZ_CP016824.1\|WP_067418363.1\|7057934_7058573_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609

Protein	Function_ID	Function_description	E-value
NZ_CP016824.1\|WP_067417816.1\|7042305_7043595_+\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	5.90105e-26
NZ_CP016824.1\|WP_067417822.1\|7046566_7048501_+\|cellulase-family-glycosylhydrolase	gnl\|CDD\|226444	COG3934, COG3934, Endo-beta-mannanase [Carbohydrate transport and metabolism].	3.32154e-29
NZ_CP016824.1\|WP_079165431.1\|7058606_7060172_+\|hypothetical-protein	gnl\|CDD\|236199	PRK08244, PRK08244, monooxygenase.	6.87041e-98
NZ_CP016824.1\|WP_008406812.1\|7044576_7045404_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.73083e-59
NZ_CP016824.1\|WP_067417819.1\|7045400_7046477_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.70197e-96
NZ_CP016824.1\|WP_067417825.1\|7048553_7050890_+\|beta-glucosidase	gnl\|CDD\|185053	PRK15098, PRK15098, beta-glucosidase BglX.	2.34896e-125
NZ_CP016824.1\|WP_159393473.1\|7060956_7061847_-\|hypothetical-protein	gnl\|CDD\|367638	pfam03756, AfsA, A-factor biosynthesis hotdog domain. The AfsA family are key enzymes in A-factor biosynthesis, which is essential for streptomycin production and resistance. This domain is distantly related to the thioester dehydratase FabZ family and therefore has a HotDog domain.	9.53968e-23
NZ_CP016824.1\|WP_018894638.1\|7043627_7044563_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.85342e-54
NZ_CP016824.1\|WP_067417805.1\|7037192_7038500_+\|MFS-transporter	gnl\|CDD\|340925	cd17367, MFS_KgtP, Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters. This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.0495e-148
NZ_CP016824.1\|WP_079165430.1\|7055166_7055505_-\|lasso-peptide-biosynthesis-B2-protein	gnl\|CDD\|379206	pfam13471, Transglut_core3, Transglutaminase-like superfamily. This family includes uncharacterized proteins that are related to the transglutaminase like domain pfam01841.	0.000537498
NZ_CP016824.1\|WP_067417808.1\|7038499_7039297_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.72502e-64
NZ_CP016824.1\|WP_067418361.1\|7055984_7056791_-\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	5.57555e-16
NZ_CP016824.1\|WP_067417829.1\|7052158_7052932_-\|transposase	gnl\|CDD\|372577	pfam13359, DDE_Tnp_4, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.33101e-15
NZ_CP016824.1\|WP_067417811.1\|7039293_7041501_+\|2-dehydropantoate-2-reductase	gnl\|CDD\|349881	cd03885, M20_CPDG2, M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme. Peptidase M20 family, Glutamate carboxypeptidase (carboxypeptidase G; carboxypeptidase G1; carboxypeptidase G2; CPDG2; CPG2; Folate hydrolase G2; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase; E.C. 3.4.17.11) subfamily. CPDG2 is a periplasmic enzyme that is synthesized with a signal peptide. It is a dimeric zinc-dependent exopeptidase, with two domains, a catalytic domain, which provides the ligands for the two zinc ions in the active site, and a dimerization domain. CPDG2 cleaves the C-terminal glutamate moiety from a wide range of N-acyl groups, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl, and pteroyl groups to release benzoic acid, phenol, and aniline mustards. It is used clinically to treat methotrexate toxicity by hydrolyzing it to inactive and non-toxic metabolites. It is also proposed for use in antibody-directed enzyme prodrug therapy; for example, glutamate can be cleaved from glutamated benzoyl nitrogen mustards, producing nitrogen mustards with effective cytotoxicity against tumor cells.	9.85266e-118
NZ_CP016824.1\|WP_008406749.1\|7056823_7057762_-\|daunorubicin/doxorubicin-resistance-ABC-transporter-ATP-binding-protein-DrrA	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	1.11639e-111
NZ_CP016824.1\|WP_067418363.1\|7057934_7058573_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	5.0934e-11

>NZ_CP016824.1|WP_067417825.1|7048553_7050890_+|beta-glucosidase
MADPLYRDPTAPVTARVRDLLARMTLTEKVGQVNQRMYGWHAYERTPSGYRLTEAFRTEVAAFDGMGALYGLQRADPWSGVTAETGIGAADGAHVSDTVQRHVIDNTRLGIPVLMVEEMPHGHQALDGTLLPVNLAVGATWNPQLYEEAVAAAAAELRARGGHVALVSALDLVRDPRWGRAEECFGEDPYLAARFTEALVRGAQGPPAERIAPDRAAVVLKHFAGQGATIGGRNSAATELGIRELHEIHLEAALAGVRAGAAGVMAAYNEFDGLPCAASRDLLTGILREEWGFDGVVMADGLALDRLVRLAGNPVAAAARALSAGCDLSLWDDCYPRLAEAVDRGLVEESALDAAVGRVLALKFRLGLFEQPYTGERPRVAAPRELSRRLAQESVTLLAHDGVTLPLPGRARVAVLGPNGDSVPQQLGDYTAPQRPGVGLSLLAGLRAAAPAGTEITYARGCDLVGADRSALPEAVALAADANVAVLVLGGSSARAAETHFDANGAAQVTGDPGGMTCGEGVDLAELALPEGQSALLDTITATGVPVVVVVVQGRPHALPDLTGRAAAVLSAWYPGPWGGQAVADILLGTAEPTGRLPVSVPRTAAQLPVFYNAKDHGYRGYVDQPATARHPFGHGLSYTTVEYGAPRLTRPAATLAEFDEADETGGTPPLVCSVEVRNTGDRPVRETVQLYVRRVLGGTSWPRVRELRGFRHTQLALGETSEVSFTVDARTLASVSRSGKREVEAGEYAIETGPSSARTQPARLTVHDERGTTFPGP
>NZ_CP016824.1|WP_067417822.1|7046566_7048501_+|cellulase-family-glycosylhydrolase
MRRHSAQLTHDHAVLPWLGANFWSRTGGPLMWRDYDPKTVREELAVLREHGLTMTRSFFYWPDFHPEPSRIDEELCDRFRDFLDAHTDAGMGTVPTFIVGHMSGENWDPVWRGGRDLYEDVWLVGRQAWFVSQMTRRFKDHPAVTGWLITNEMPGYGRIYQENPPSGDVVTAWAQFMCDAVRAAGGTQPVSLGDGAWGIEVTGRDNGFSLRDTAEYVDFVGPHVYRSDTDRPRQHYRAAFECELAAVTGQPVVLEEFGLSTDTVSAANAGIFYRQTLHNSLLGGATGWIAWNNTDYDALWDRSPYDHHPFEMHFGITDSEGRPKEPLRELAGFAEVLERVDFARCRRTDADAALVVPAFLERGYPYSRPADRPLIFTSLHQGYVAARGADLPVALTREADGLAEDAALYLLPSTRQLTTRTRRALERRAREGATVYLSFCSGEHPGTRGPWFDDLDGLFGVELQLSYGVAEPIEDDVLEMTFTEEFGTIKAGETLTFPVAGNEDSRAYLPVVPDGARVVATDAHGRPALLRHDTGQGRTVLATYPLEHMAARTARVNPEQTHRLYAALAEIAGAARPVTVDSPHVAADTLVHEDGRRFVWLVSQSGTELTVRPSADGTLHSLADGDPVRDVTLPPYGVRVLEQR
>NZ_CP016824.1|WP_067417819.1|7045400_7046477_+|LacI-family-transcriptional-regulator
MKERLEGRPGRSAPGNGTRPTIKAVAAAAGVSTATVSQAVNDTGRISDATRRRVLAAAAELGWSPSAPATALRRARTRTIALVVRRPTDVLGADPHFSELITGLEGQLAPRGYGLLLHLVPDMAEESALYERLAAEGRIDGAVLTDARADDPRPGLLQGLGLPAVLLGAPDPAAPVPGVGLGQQDAGVREAVTHLLNHGHRRIAYVAGPADLLHSGLRRAAFESALAEAGLRPLAVRHTDFTEEAAVTVTTELLARPDRPTALVFPNDSMAVCGMGAAQRAGLRVPEDVSVVGYDNLPLGRWLHPRLTTVDQQVQRVGAAAALTLLAGCGEEVPAPLLDGRPRLVVRESTGPAPAGRP
>NZ_CP016824.1|WP_008406812.1|7044576_7045404_+|carbohydrate-ABC-transporter-permease
MKFGRSWLPAHLLAWLYAALLLVPLYYLLVSAFKTNDQIFGSPFALPTSLSPHNFTEAFTSADLGAAVVNSVLVTALALALTLGLAIPAAFALARSDGRLGAFVERVFSLGFLVPTFAALFPTFLLAASTGLFHTRAFMVLFLPATAMPLSVVILVQFMRTIPREMEEAARMDGASTFAVLRHVYTPMCMPGIATILLLNFLTFWNEYLYSLVIIGPDPGLRTVQVALPTLKSLTGTDYGILTAGTVLTLVPVWAVYTVLQKRMQQALVSGAVKM
>NZ_CP016824.1|WP_018894638.1|7043627_7044563_+|sugar-ABC-transporter-permease
MTLLSSAPPGAPATRSAPQAPGRTPRRKQGGVILAVPALAWYLLFMVGPLVAIFVIAALHWPGMLQPVSFAGLGNVRTVLADPVFTDALVNTGIQLAVALPVMIVGAYMLGYYVAQRPPGHRFLRYLLFIPGLISTPAKAMVFYAVLSPDGLFNGALDKAGLGSLTDAWLASPSTALACLIVLDVWSGIGFTAVLFAARLGSVPDEVGEAAQLDGAGHWRAMWRIHFPMIRDFVGVVTMLQFLWTLFGSAQNVLLLTQGGPGSSSTTLSFLVYQKAFIAADLGYSQTVGVFLFLAGLAGLLTIRRVFRQNY
>NZ_CP016824.1|WP_067417816.1|7042305_7043595_+|carbohydrate-ABC-transporter-substrate-binding-protein
MRSPLSRRGFLAAGSGLAAATAFPALAGCSSLASADSDPGTLVVHTQLGTTAPGSPTYRALVKEFHAEHPGLRIKNLVNGDDLPQVYETSRLARKEPDVVMVNLYDKTLAWTELGATLDVKGYLDDWGLRERVLPAALKEWTDDEGRLRAFPYFAANWPVAFNTSLLERAGAGSVPTTADQLIGAARKLRAKGIAPVTVGGNDWTGQKLLAQIIQTFLTPEEARKVYASGDFGGRRVREGIDYFVELRDSGVFADKAQGLTSDTMTTQYNTEAAAIQSAMSSALAKVPERTAAHSEVGGWPLAPGAAHAKPTIMRSYTLIGFWISPNGAKKISAVEKFLRFMYRPESVSRFITESGRDMALRTDTVSKDFPLVAAAQRLGDRVGQVLLPDLYVPPTATQPLITATSTAFTRGTSAATVRSALESAYRTG
>NZ_CP016824.1|WP_067417814.1|7041727_7042129_+|hypothetical-protein
MRVARPLSLFAALSIALAGAVGTATAAPAPAPEAAAAGSGYAAPTMLHCKLNVRSATKSSATVLRTLRNRNGNCPGKGGHDSVPCWLNKCGGITAGGSYTCQSGGKSYKSWLPVKHQGKRAWVAIKCGTYVTP
>NZ_CP016824.1|WP_067417811.1|7039293_7041501_+|2-dehydropantoate-2-reductase
MSSTDTYTVVGGGAIGGTLAFSLARAGHRVRLVDTDAAHVAAVREHGLTVARGEQRESVHVEAVTPDACDATLGRVLLAVKAQATGAALDWIEPRLAPDGWVVSLQNGFNEELIARRIGAGRTVAAFVNIFADVTEPGVIMDGGAGALVIGECHGAPVSDRVDSLVADLQSWGPALASDNVEGYLWAKAGFGAMLAATALADAPMAELIDRHPATMDAVAAEVFAVADALGVTLEAFDAFEPHAFRRDAAEETRRAATARLTAWLRTQAKDRSGIWRDLAVRRRPVEVTTHYAEVFAEAGRHGVATPVLRAVITQLRELERDPGLMTEARLDALDQLASGSRREFADTAAPGRDQAAAVRDWLAAHREEMVADLAEYTSQESASDDLEALDACLAWVRHWLDNALGAPAHEEIRPRAEAGDLMIRRYPGTGARPVLLLGHYDTVWPTGTLDQWPFRRDGDRITGPGVFDMKAGLVQAVWALKALDALGLARPACTLLLNGDEETGSLASSDDLVAEARESRAALVFEAAADGAVKTARKGVGLFTVTVTGQEAHAGLDPQAGASATEELAHQILRLAGLRDLAAGTSLNAGVIEGGTRSNVTAGRATARLDVRVATAAEQERIGAALAALRPVDPRTTVEVSGGWNRPVFERTGQVAELAGLAQRCAATLGLDLREAAVGGASDGNFVVAAGVPVLDGIGAVGSGAHARSENTSVNGMVERAALTATVLTALAGS
>NZ_CP016824.1|WP_067417808.1|7038499_7039297_+|SDR-family-oxidoreductase
MSHVLVTGAAGGIGRAIATRFAAQGATLTLADRERAPLDDFAAHLPTATGVLTADLTAPDAPAELVRRAWDEQGPVDVLVNAAGVYPSLDMAELTAEAWDRLFAVNLRAPVLATAAYARLATERGEGGTVVNISSGSALRARPGGGPYASSKAALEMATRAAALELGAHGIRVNAVSPGFVPVDSACNPVSEEYAAAIGANPLGRPGSPEDIARAVCWIAGPEAAWITGEILRVDGGSSTGALHLPRIWPPATPAPADATKGHPA
>NZ_CP016824.1|WP_067417805.1|7037192_7038500_+|MFS-transporter
MSTEPRTPPAPGPAHKLTGKQRKAIVAGTIGNTVEWVDWALYSIFAKIIADEFFPSGNEAVALLSTLAVFAVGFVMRPVGAAVLGVYADRHGRKKGMTLTVGLMAGAAFVIALTPSYDTIGVLAPLVLLLARLVQGFSAGGEFGSSSAFLVESAARGRRAFAGSWQQVSVAGGVLIASLLGTLTTSLLSDETLHSWGWRIAFVIGGLLGLVGLWLRVSVEDTDSFTRAQGSGRTRSNPLKAMFVEHPGAALRVAGITIAGTLTYYIWVNYLPTYANLTTGIPLSTALLSQTLCLVVFVVLLPFVGLLSDRLGRKPTMAAFAGGFVVLAWPLLHLLDNSFLSLFLVQLTGMLLILGYSANCAVIMAEQFPAEIRATGIALPYALAVALFGGTAPYLTTWMHESGHSDLLWLYVAGASLVSFLVYVTMPETKNKEFH
>NZ_CP016824.1|WP_067417829.1|7052158_7052932_-|transposase
MTGVITASEPSWIGPFTGLSPRQFNKLITALRREGADPVRKGRPWSLPLEDRVLLVAAYWRTNLTLRQLAPLFGVSKSAADRIVTHLGPALALRPRRRFRKETVLIVDGTLVPTRDRTVAASSKNYRYSTNHQVVIDADTRLVVAVGKPLPGNRNDCVAWQDSGAKAAVGTTPTVIADGGYRGTGLTIPHYRRHKDEELPAWKEEHNASHRKVRARVEHTFARMKSWKILRDCRLKSDGVHYAMLGIARLHNLTLTG
>NZ_CP016824.1|WP_143067295.1|7053008_7054349_+|hypothetical-protein
MAIASAITLLLPAAASAATTSAQENAAQEVKATQSDVQRQPKGMPSDYEVLPEKGGYSQTSNCTEVRGNLDSLAKAGQDRAVCVEWGSPKESSKTKILGPRDNGSVWCYGQKENLVYATRTELCSVRTAHLLVLEVPTGRVLGNAYGVIEQEIETQNGKPEFFEYLNFTLVDTDMATAGMTVSLTPVCSLDTSCKQSVDPWDKPRPVVEGRSVDGTISRLWTGDQGNKSFLLSYKMHVTIPAGSGTWDWGVDGGPGDGQYLVRCDNEVGATKGCMVPAFRPTFEVDRKYKEARQFIGMVQASMSSHPGWEGHGEPLHRESVQSEVDKNRAIVCDSTFSKWPSTPDPAQCDEFPFARTKESGRRMGVTSGASCQQYFVTSQTIEGQVYLSLLWYGYTNGEMPPADAKCARASMPKNQNEGVGGDLGRKTIQWRLLENDAYWVDAGNG
>NZ_CP016824.1|WP_143067296.1|7054547_7055090_+|hypothetical-protein
MSGQKVFQFHLNRIEAEAIKALGEDIEEEDVPDLNLEELYESGILNNSGPLLRAGTYNDWSFAIESEGPYLADDRLLRTASQNTEAISARVSETGSKWISYAERGEILSSFDPLFPHHDYGSRPSILEWLTNYQEAISRGDRADSFENAFREIQHALNCAVPKEADALRLLTVRVAGAYS
>NZ_CP016824.1|WP_079165430.1|7055166_7055505_-|lasso-peptide-biosynthesis-B2-protein
MCSSLGMSGPTACGTPLLDFETPPSPPPSIRPAWYRGRIACMEISLATVLALALCGRQAHVVLGARQLPTEAHAWVWTENGAFGLSGRDRPDPRRPWAGALAAPPVPKGRRT
>NZ_CP016824.1|WP_067418358.1|7055503_7055758_+|hypothetical-protein
MSDLPADLPCLHVLRTWHAMWLARIDKAIATAEQREAETRRGAEVRPPLAGARVRPLDTEQARQALVDVEACSMCRPDTDLGLL
>NZ_CP016824.1|WP_067418361.1|7055984_7056791_-|ABC-transporter-permease
MTTTHGSGSKLSWAFADSWTMTRRELAHWARQPVQVVVGLVFPVMMLLMFGFLIGGGKGVEGDFTSYLVPGMLTMTMAFGLEATMLSVTQDLGKGVIDRFRSMPMNSGSILVGRSIADMLQSVVGLAVMIGVGAAIGWRWNNGFASFMGAVGLLLLLRFAMLWIGLHLAMVAGKPEMVQAVQILVWPMAFLSNAIATPASMPAWLGAVVEWNPMSATATAVRDLFGNQSAAGDSWAATHAELLAVAWPLLLVAIFFPLAVKRFRDLSR
>NZ_CP016824.1|WP_008406749.1|7056823_7057762_-|daunorubicin/doxorubicin-resistance-ABC-transporter-ATP-binding-protein-DrrA
MSDRDLAIVVEGLRKKYKDKQALDGLDLTVRAGTVQGILGPNGAGKTTAVRIMSTLLRADEGRVEVAGIDVRTRADDVRSQIGLLGQNAAVDEELSGRQNLEMFGRLYHLGARRAGARADELLEQFGLTETGTKAVKQYSGGMRRRLDLAASLISRPQVLFLDEPTTGLDPRGRTEVWNAVRSLVGGGTTVLLTTQYLEEADQLADQIAVINRGQVIAEGTADELKTKTGGDRIDVILHDVAQLERAASLLPGAVDKDEDRRMVSASISNRMAALTETVRALQEAGIEAEDIAVRRPTLDEVFMHLTKEEAA
>NZ_CP016824.1|WP_067418363.1|7057934_7058573_+|PadR-family-transcriptional-regulator
MSPIRLLVLGAVRQHGRAHGYQVRNDLEYWGAHEWSSAKPGSIYHALKQMTKQGLLIAHEIAPSTAGGPPRVEYELNEQGAAEYFRLLRDALSSHEQKSDDLSAGLGFIVDLPRGEAIALLKERVSGLEQWRSAVTGYYTPEAGPEQLGHIGEIMNLWVHSADAGVRWTRGLIERIEGGAYTFAGEGDPFVGVLADDEPNPFAPDRQPEGVH
>NZ_CP016824.1|WP_079165431.1|7058606_7060172_+|hypothetical-protein
MVKKPDARYIPHHCRGGAAVQENGRLRTQVAVVGGGPVGMLLAAELASHGVGTVLLEVRGDVSERPKANTLHARAVQCLARRGHLPGPETGSARGATGLPFHFAGLPGLVITAPDREPQPLLKYPQAQLERGFEERAQTAGARILRGHRVTEIAERDGGVRIEAEGPHGRGVRVEAQYVVGADGARSAVREQAAITTDTGPATVSALMGAVTLTDPGVLPDGWQHTARGWIVAKRDAGGHTHVRTLDCRGAHPGRHAPPTLEELRREVSRIAGRDIAMTQPRWLDRFSDVTRLARTFRAGRVFLAGDAAHVHFPIGGQGLSTGVLDALNLGWKLALAVRGRAGAGLLDTYDAERRPSAQRVIDNTQAQLALMRPGPELDALRTVFRSLLLTDQESGRRLGDLISAQDTVLPAPTGDGGPAAGTFLANLALTTEAGDTDVIELLQEGRPLLLLLGDGGVRHLDRARAWGRTLKVVRARPVPDVPYEAALVRPDGYLAWTSDGGDLGTALSAYVAEDAGAGRP
>NZ_CP016824.1|WP_159393473.1|7060956_7061847_-|hypothetical-protein
MAEVLLTGWRRVDDTRFVISAQWPRGHSFFTPVADGRHDPLIGCETLRQIGILLGHAEFGVPFGHQFLIQDLHFAVRPQHLAVGYEPAALSISVTCTQVVRRGENLARMRFEAVFRRNGQVAATGGGSFSCLAPKVYRRLRGAHLPSGDCGPSAPGSPTAPARVGRLSPMDVVLSPTDARNRWLLRADTRHPVLFEHAVDHVPGMVLIEAARQATAVALDRPHYLPVNLACEFARYTELAQPCTIEARPLSAPPREAAEASWRPRCRAASRSSPAPSRPHRTGTDVLRGDLGSTPP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP016824_4	4.2\|1604612\|30\|NZ_CP016824\|CRISPRCasFinder	1604612-1604641	30	NZ_CP016824.1	1989664-1989693	0	1.0
NZ_CP016824_19	19.1\|3674022\|39\|NZ_CP016824\|CRISPRCasFinder	3674022-3674060	39	NZ_CP016824.1	1309297-1309335	0	1.0
NZ_CP016824_19	19.1\|3674022\|39\|NZ_CP016824\|CRISPRCasFinder	3674022-3674060	39	NZ_CP016824.1	4295940-4295978	0	1.0
NZ_CP016824_19	19.1\|3674022\|39\|NZ_CP016824\|CRISPRCasFinder	3674022-3674060	39	NZ_CP016824.1	1652003-1652041	1	0.974
NZ_CP016824_21	21.1\|3967952\|31\|NZ_CP016824\|CRISPRCasFinder	3967952-3967982	31	NZ_CP016824.1	2832035-2832065	1	0.968
NZ_CP016824_25	25.1\|4214981\|30\|NZ_CP016824\|PILER-CR	4214981-4215010	30	NZ_CP016824.1	2832639-2832668	1	0.967
NZ_CP016824_25	25.1\|4214981\|30\|NZ_CP016824\|PILER-CR	4214981-4215010	30	NZ_CP016824.1	4464653-4464682	1	0.967
NZ_CP016824_4	4.2\|1604612\|30\|NZ_CP016824\|CRISPRCasFinder	1604612-1604641	30	NZ_CP016824.1	2943095-2943124	2	0.933
NZ_CP016824_19	19.1\|3674022\|39\|NZ_CP016824\|CRISPRCasFinder	3674022-3674060	39	NZ_CP016824.1	2400174-2400212	2	0.949
NZ_CP016824_25	25.1\|4214981\|30\|NZ_CP016824\|PILER-CR	4214981-4215010	30	NZ_CP016824.1	4464801-4464830	2	0.933
NZ_CP016824_29	29.1\|4788507\|41\|NZ_CP016824\|CRISPRCasFinder	4788507-4788547	41	NZ_CP016824.1	2400172-2400212	2	0.951

1. spacer 4.2|1604612|30|NZ_CP016824|CRISPRCasFinder matches to position: 1989664-1989693, mismatch: 0, identity: 1.0

aaccagcccggccggcgcttgaggccaaac	CRISPR spacer
aaccagcccggccggcgcttgaggccaaac	Protospacer
******************************

2. spacer 19.1|3674022|39|NZ_CP016824|CRISPRCasFinder matches to position: 1309297-1309335, mismatch: 0, identity: 1.0

ctttgaccggcacggtcgagacggagcccggcacacaac	CRISPR spacer
ctttgaccggcacggtcgagacggagcccggcacacaac	Protospacer
***************************************

3. spacer 19.1|3674022|39|NZ_CP016824|CRISPRCasFinder matches to position: 4295940-4295978, mismatch: 0, identity: 1.0

ctttgaccggcacggtcgagacggagcccggcacacaac	CRISPR spacer
ctttgaccggcacggtcgagacggagcccggcacacaac	Protospacer
***************************************

4. spacer 19.1|3674022|39|NZ_CP016824|CRISPRCasFinder matches to position: 1652003-1652041, mismatch: 1, identity: 0.974

ctttgaccggcacggtcgagacggagcccggcacacaac	CRISPR spacer
ctttgaccggcacggtcgggacggagcccggcacacaac	Protospacer
******************.********************

5. spacer 21.1|3967952|31|NZ_CP016824|CRISPRCasFinder matches to position: 2832035-2832065, mismatch: 1, identity: 0.968

ctttggcctcaagcgccggccgggctggttt	CRISPR spacer
ctttggcctcaagcgccggccgggctgattt	Protospacer
***************************.***

6. spacer 25.1|4214981|30|NZ_CP016824|PILER-CR matches to position: 2832639-2832668, mismatch: 1, identity: 0.967

ggcacggtcgagacggagcccggcaatcga	CRISPR spacer
ggcacggtcgagacggagcccggcaaccga	Protospacer
**************************.***

7. spacer 25.1|4214981|30|NZ_CP016824|PILER-CR matches to position: 4464653-4464682, mismatch: 1, identity: 0.967

ggcacggtcgagacggagcccggcaatcga	CRISPR spacer
ggcacggtcgagacggagcccggcaaccga	Protospacer
**************************.***

8. spacer 4.2|1604612|30|NZ_CP016824|CRISPRCasFinder matches to position: 2943095-2943124, mismatch: 2, identity: 0.933

aaccagcccggccggcgcttgaggccaaac	CRISPR spacer
aatcagcccggccggcgcttgaggccacac	Protospacer
**.************************ **

9. spacer 19.1|3674022|39|NZ_CP016824|CRISPRCasFinder matches to position: 2400174-2400212, mismatch: 2, identity: 0.949

ctttgaccggcacggtcgagacggagcccggcacacaac	CRISPR spacer
ctttgaccggcacggtcgagacggagcacggcacccaac	Protospacer
*************************** ****** ****

10. spacer 25.1|4214981|30|NZ_CP016824|PILER-CR matches to position: 4464801-4464830, mismatch: 2, identity: 0.933

ggcacggtcgagacggagcccggcaatcga	CRISPR spacer
ggcacggtcgagacggggcccggcaaccga	Protospacer
****************.*********.***

11. spacer 29.1|4788507|41|NZ_CP016824|CRISPRCasFinder matches to position: 2400172-2400212, mismatch: 2, identity: 0.951

gtctttgaccggcacggtcgagagggagcccggcacccaac	CRISPR spacer
gtctttgaccggcacggtcgagacggagcacggcacccaac	Protospacer
*********************** ***** ***********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP016824_33	33.2\|5179932\|21\|NZ_CP016824\|CRISPRCasFinder	5179932-5179952	21	NZ_CP027023	Streptomyces sp. WAC00288 plasmid p1, complete sequence	29911-29931	1	0.952
NZ_CP016824_31	31.1\|5175228\|24\|NZ_CP016824\|PILER-CR	5175228-5175251	24	NZ_CP040453	Halomonas sp. PA16-9 plasmid p_unnamed2, complete sequence	53138-53161	2	0.917
NZ_CP016824_31	31.1\|5175228\|24\|NZ_CP016824\|PILER-CR	5175228-5175251	24	NZ_CP029835	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed5, complete sequence	270724-270747	4	0.833
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NZ_JX627580	Methylobacterium oryzae CBMB20 plasmid pMOC1, complete sequence	63924-63956	4	0.879
NZ_CP016824_11	11.2\|2661373\|27\|NZ_CP016824\|PILER-CR	2661373-2661399	27	NZ_CP016293	Rhizobium leguminosarum strain Vaf10 plasmid unnamed5, complete sequence	231441-231467	5	0.815
NZ_CP016824_20	20.1\|3778550\|30\|NZ_CP016824\|CRT	3778550-3778579	30	MF477236	Nocardia phage NTR1, complete genome	27627-27656	5	0.833
NZ_CP016824_20	20.2\|3778611\|30\|NZ_CP016824\|CRT	3778611-3778640	30	MF477236	Nocardia phage NTR1, complete genome	27627-27656	5	0.833
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NZ_CP015737	Shinella sp. HZN7 plasmid pShin-01, complete sequence	80295-80324	5	0.833
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NZ_CP025810	Sulfitobacter sp. SK025 plasmid unnamed2, complete sequence	118173-118202	5	0.833
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP025014	Rhizobium leguminosarum strain Norway plasmid pRLN2, complete sequence	448738-448769	5	0.844
NZ_CP016824_7	7.2\|2167041\|32\|NZ_CP016824\|CRISPRCasFinder	2167041-2167072	32	NC_017805	Deinococcus gobiensis I-0 plasmid P1, complete sequence	105310-105341	6	0.812
NZ_CP016824_7	7.3\|2167102\|32\|NZ_CP016824\|CRISPRCasFinder	2167102-2167133	32	LR134125	Klebsiella aerogenes strain NCTC10006 genome assembly, plasmid: 5	458700-458731	6	0.812
NZ_CP016824_18	18.1\|3474385\|28\|NZ_CP016824\|PILER-CR	3474385-3474412	28	NZ_CP020717	Cnuibacter physcomitrellae strain XA(T) plasmid unnamed2, complete sequence	69494-69521	6	0.786
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP025014	Rhizobium leguminosarum strain Norway plasmid pRLN2, complete sequence	448739-448768	6	0.8
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP025431	Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence	169215-169244	6	0.8
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1873783-1873812	6	0.8
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	760171-760200	6	0.8
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	MK880124	Microbacterium phage IAmGroot, complete genome	19985-20014	6	0.8
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NC_016624	Azospirillum lipoferum 4B plasmid AZO_p5, complete sequence	220847-220876	6	0.8
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NZ_CP049249	Rhizobium rhizoryzae strain DSM 29514 plasmid unnamed3, complete sequence	179113-179142	6	0.8
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NZ_CP010408	Streptomyces vietnamensis strain GIMV4.0001 plasmid pSVL1, complete sequence	12290-12319	6	0.8
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NZ_CP010626	Phaeobacter inhibens strain P51 plasmid pP51_c, complete sequence	44836-44865	6	0.8
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NZ_CP010671	Phaeobacter inhibens strain P57 plasmid pP57_c, complete sequence	44921-44950	6	0.8
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NZ_CP010744	Phaeobacter inhibens strain P59 plasmid pP59_c, complete sequence	44889-44918	6	0.8
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NZ_CP010622	Phaeobacter inhibens strain P30 isolate M4-3.1A plasmid pP30_e, complete sequence	44897-44926	6	0.8
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NZ_CP010702	Phaeobacter inhibens strain P24 plasmid pP24_f, complete sequence	44963-44992	6	0.8
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NZ_CP010748	Phaeobacter inhibens strain P48 isolate M21-2.3 plasmid pP48_c, complete sequence	44895-44924	6	0.8
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NZ_CP015737	Shinella sp. HZN7 plasmid pShin-01, complete sequence	80294-80325	6	0.812
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NZ_CP025810	Sulfitobacter sp. SK025 plasmid unnamed2, complete sequence	118172-118203	6	0.812
NZ_CP016824_25	25.1\|4214981\|30\|NZ_CP016824\|PILER-CR	4214981-4215010	30	NZ_CP013855	Pseudonocardia sp. HH130630-07 plasmid pLS2-1, complete sequence	230828-230857	6	0.8
NZ_CP016824_25	25.1\|4214981\|30\|NZ_CP016824\|PILER-CR	4214981-4215010	30	NC_023724	Mycobacterium phage Larva, complete genome	28893-28922	6	0.8
NZ_CP016824_25	25.1\|4214981\|30\|NZ_CP016824\|PILER-CR	4214981-4215010	30	MF185717	Mycobacterium phage AlleyCat, complete genome	29025-29054	6	0.8
NZ_CP016824_32	32.3\|5179419\|33\|NZ_CP016824\|CRISPRCasFinder	5179419-5179451	33	NZ_CP025986	Ralstonia solanacearum strain RSCM plasmid p-unname2, complete sequence	1041654-1041686	6	0.818
NZ_CP016824_32	32.3\|5179419\|33\|NZ_CP016824\|CRISPRCasFinder	5179419-5179451	33	NZ_CP019938	Ketogulonicigenium robustum strain SPU_B003 plasmid unnamed1, complete sequence	162734-162766	6	0.818
NZ_CP016824_32	32.6\|5179626\|33\|NZ_CP016824\|CRISPRCasFinder	5179626-5179658	33	NZ_CP018784	Curtobacterium pusillum strain AA3 plasmid pCPAA3, complete sequence	272561-272593	6	0.818
NZ_CP016824_36	36.1\|5688372\|34\|NZ_CP016824\|CRISPRCasFinder	5688372-5688405	34	NZ_CP029833	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence	393389-393422	6	0.824
NZ_CP016824_38	38.1\|7051446\|32\|NZ_CP016824\|CRISPRCasFinder	7051446-7051477	32	NZ_CP034351	Streptomyces sp. W1SF4 plasmid p1, complete sequence	28370-28401	6	0.812
NZ_CP016824_4	4.2\|1604612\|30\|NZ_CP016824\|CRISPRCasFinder	1604612-1604641	30	MH045568	Microbacterium phage Kieran, complete genome	12875-12904	7	0.767
NZ_CP016824_4	4.2\|1604612\|30\|NZ_CP016824\|CRISPRCasFinder	1604612-1604641	30	MN062717	Microbacterium phage Sharkboy, complete genome	12871-12900	7	0.767
NZ_CP016824_4	4.2\|1604612\|30\|NZ_CP016824\|CRISPRCasFinder	1604612-1604641	30	MT310853	Microbacterium phage AvGardian, complete genome	12858-12887	7	0.767
NZ_CP016824_4	4.2\|1604612\|30\|NZ_CP016824\|CRISPRCasFinder	1604612-1604641	30	NC_042099	Microbacterium phage Dismas, complete genome	12872-12901	7	0.767
NZ_CP016824_4	4.2\|1604612\|30\|NZ_CP016824\|CRISPRCasFinder	1604612-1604641	30	NZ_LN832562	Paracoccus aminovorans isolate JCM7685 plasmid IV, complete sequence	359894-359923	7	0.767
NZ_CP016824_20	20.1\|3778550\|30\|NZ_CP016824\|CRT	3778550-3778579	30	NZ_CP050092	Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence	56404-56433	7	0.767
NZ_CP016824_20	20.2\|3778611\|30\|NZ_CP016824\|CRT	3778611-3778640	30	NZ_CP050092	Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence	56404-56433	7	0.767
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP016820	Rhodococcus sp. p52 plasmid pDF02, complete sequence	215822-215851	7	0.767
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP045120	Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence	155932-155961	7	0.767
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP015268	Mycobacterium chimaera strain ZUERICH-2 plasmid unnamed 1, complete sequence	138007-138036	7	0.767
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1245741-1245770	7	0.767
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP024310	Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence	826691-826720	7	0.767
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	588889-588918	7	0.767
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP023064	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence	647068-647097	7	0.767
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1523097-1523126	7	0.767
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP017941	Phyllobacterium zundukense strain Tri-48 plasmid unnamed1, complete sequence	362019-362048	7	0.767
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP015279	Mycobacterium chimaera strain DSM 44623 plasmid unnamed 1, complete sequence	115744-115773	7	0.767
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1543499-1543528	7	0.767
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_LR134463	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 21, complete sequence	132305-132336	7	0.781
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NZ_CP010408	Streptomyces vietnamensis strain GIMV4.0001 plasmid pSVL1, complete sequence	12289-12320	7	0.781
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NZ_CP010626	Phaeobacter inhibens strain P51 plasmid pP51_c, complete sequence	44835-44866	7	0.781
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NZ_CP010671	Phaeobacter inhibens strain P57 plasmid pP57_c, complete sequence	44920-44951	7	0.781
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NZ_CP010744	Phaeobacter inhibens strain P59 plasmid pP59_c, complete sequence	44888-44919	7	0.781
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NZ_CP010622	Phaeobacter inhibens strain P30 isolate M4-3.1A plasmid pP30_e, complete sequence	44896-44927	7	0.781
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NZ_CP010702	Phaeobacter inhibens strain P24 plasmid pP24_f, complete sequence	44962-44993	7	0.781
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NZ_CP010748	Phaeobacter inhibens strain P48 isolate M21-2.3 plasmid pP48_c, complete sequence	44894-44925	7	0.781
NZ_CP016824_21	21.1\|3967952\|31\|NZ_CP016824\|CRISPRCasFinder	3967952-3967982	31	MH045568	Microbacterium phage Kieran, complete genome	12875-12905	7	0.774
NZ_CP016824_21	21.1\|3967952\|31\|NZ_CP016824\|CRISPRCasFinder	3967952-3967982	31	MN062717	Microbacterium phage Sharkboy, complete genome	12871-12901	7	0.774
NZ_CP016824_21	21.1\|3967952\|31\|NZ_CP016824\|CRISPRCasFinder	3967952-3967982	31	MT310853	Microbacterium phage AvGardian, complete genome	12858-12888	7	0.774
NZ_CP016824_21	21.1\|3967952\|31\|NZ_CP016824\|CRISPRCasFinder	3967952-3967982	31	NC_042099	Microbacterium phage Dismas, complete genome	12872-12902	7	0.774
NZ_CP016824_21	21.1\|3967952\|31\|NZ_CP016824\|CRISPRCasFinder	3967952-3967982	31	NZ_LN832562	Paracoccus aminovorans isolate JCM7685 plasmid IV, complete sequence	359894-359924	7	0.774
NZ_CP016824_25	25.1\|4214981\|30\|NZ_CP016824\|PILER-CR	4214981-4215010	30	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	1447619-1447648	7	0.767
NZ_CP016824_25	25.1\|4214981\|30\|NZ_CP016824\|PILER-CR	4214981-4215010	30	NZ_CP016617	Microvirga ossetica strain V5/3m plasmid unnamed1, complete sequence	425112-425141	7	0.767
NZ_CP016824_26	26.1\|4595263\|54\|NZ_CP016824\|CRISPRCasFinder	4595263-4595316	54	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	233324-233377	7	0.87
NZ_CP016824_32	32.3\|5179419\|33\|NZ_CP016824\|CRISPRCasFinder	5179419-5179451	33	CP054924	Verrucosispora sp. NA02020 plasmid unnamed, complete sequence	67068-67100	7	0.788
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NC_016585	Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence	568224-568256	7	0.788
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NZ_CP040761	Paracoccus sp. 2251 plasmid unnamed5, complete sequence	60415-60447	7	0.788
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NZ_LR134463	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 21, complete sequence	68312-68344	7	0.788
NZ_CP016824_38	38.1\|7051446\|32\|NZ_CP016824\|CRISPRCasFinder	7051446-7051477	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	4516412-4516443	7	0.781
NZ_CP016824_4	4.2\|1604612\|30\|NZ_CP016824\|CRISPRCasFinder	1604612-1604641	30	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	151946-151975	8	0.733
NZ_CP016824_7	7.1\|2166980\|32\|NZ_CP016824\|CRISPRCasFinder	2166980-2167011	32	MH727545	Mycobacterium phage DismalStressor, complete genome	50492-50523	8	0.75
NZ_CP016824_7	7.1\|2166980\|32\|NZ_CP016824\|CRISPRCasFinder	2166980-2167011	32	NC_026598	Mycobacterium phage Milly, complete genome	50483-50514	8	0.75
NZ_CP016824_7	7.1\|2166980\|32\|NZ_CP016824\|CRISPRCasFinder	2166980-2167011	32	MH834601	Mycobacterium phage BoostSeason, complete genome	49963-49994	8	0.75
NZ_CP016824_7	7.1\|2166980\|32\|NZ_CP016824\|CRISPRCasFinder	2166980-2167011	32	KX688047	Mycobacterium phage Marcoliusprime, complete genome	50492-50523	8	0.75
NZ_CP016824_7	7.1\|2166980\|32\|NZ_CP016824\|CRISPRCasFinder	2166980-2167011	32	NC_028759	Mycobacterium phage Mufasa, complete genome	49950-49981	8	0.75
NZ_CP016824_7	7.1\|2166980\|32\|NZ_CP016824\|CRISPRCasFinder	2166980-2167011	32	MF140408	Mycobacterium phage DismalFunk, complete genome	50492-50523	8	0.75
NZ_CP016824_7	7.1\|2166980\|32\|NZ_CP016824\|CRISPRCasFinder	2166980-2167011	32	MF140411	Mycobacterium phage Findley, complete genome	50510-50541	8	0.75
NZ_CP016824_7	7.3\|2167102\|32\|NZ_CP016824\|CRISPRCasFinder	2167102-2167133	32	NZ_CP048789	Roseobacter ponti strain DSM 106830 plasmid p1, complete sequence	14850-14881	8	0.75
NZ_CP016824_7	7.3\|2167102\|32\|NZ_CP016824\|CRISPRCasFinder	2167102-2167133	32	CP003953	Rhodococcus opacus PD630 plasmid 4, complete sequence	47378-47409	8	0.75
NZ_CP016824_7	7.3\|2167102\|32\|NZ_CP016824\|CRISPRCasFinder	2167102-2167133	32	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	383992-384023	8	0.75
NZ_CP016824_7	7.3\|2167102\|32\|NZ_CP016824\|CRISPRCasFinder	2167102-2167133	32	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	1029143-1029174	8	0.75
NZ_CP016824_7	7.3\|2167102\|32\|NZ_CP016824\|CRISPRCasFinder	2167102-2167133	32	NZ_CP038636	Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence	350920-350951	8	0.75
NZ_CP016824_7	7.3\|2167102\|32\|NZ_CP016824\|CRISPRCasFinder	2167102-2167133	32	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1103232-1103263	8	0.75
NZ_CP016824_18	18.1\|3474385\|28\|NZ_CP016824\|PILER-CR	3474385-3474412	28	NZ_CP049322	Caballeronia sp. SBC2 plasmid pSBC2-6, complete sequence	1899-1926	8	0.714
NZ_CP016824_20	20.1\|3778550\|30\|NZ_CP016824\|CRT	3778550-3778579	30	NC_014159	Tsukamurella paurometabola DSM 20162 plasmid pTpau01, complete sequence	83241-83270	8	0.733
NZ_CP016824_20	20.1\|3778550\|30\|NZ_CP016824\|CRT	3778550-3778579	30	MT114163	Mycobacterium phage Settecandela, complete genome	123207-123236	8	0.733
NZ_CP016824_20	20.1\|3778550\|30\|NZ_CP016824\|CRT	3778550-3778579	30	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3988629-3988658	8	0.733
NZ_CP016824_20	20.1\|3778550\|30\|NZ_CP016824\|CRT	3778550-3778579	30	NZ_CP021355	Rhodococcus sp. S2-17 plasmid pRB98, complete sequence	969791-969820	8	0.733
NZ_CP016824_20	20.2\|3778611\|30\|NZ_CP016824\|CRT	3778611-3778640	30	NC_014159	Tsukamurella paurometabola DSM 20162 plasmid pTpau01, complete sequence	83241-83270	8	0.733
NZ_CP016824_20	20.2\|3778611\|30\|NZ_CP016824\|CRT	3778611-3778640	30	MT114163	Mycobacterium phage Settecandela, complete genome	123207-123236	8	0.733
NZ_CP016824_20	20.2\|3778611\|30\|NZ_CP016824\|CRT	3778611-3778640	30	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3988629-3988658	8	0.733
NZ_CP016824_20	20.2\|3778611\|30\|NZ_CP016824\|CRT	3778611-3778640	30	NZ_CP021355	Rhodococcus sp. S2-17 plasmid pRB98, complete sequence	969791-969820	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NC_003037	Sinorhizobium meliloti 1021 plasmid pSymA, complete sequence	496714-496743	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP019585	Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymA, complete sequence	618632-618661	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NC_017324	Sinorhizobium meliloti BL225C plasmid pSINMEB01, complete sequence	990245-990274	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP021827	Sinorhizobium meliloti strain KH35c plasmid psymA, complete sequence	685107-685136	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NC_018683	Sinorhizobium meliloti Rm41 plasmid pSYMA, complete sequence	777446-777475	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP021805	Sinorhizobium meliloti strain T073 plasmid psymA, complete sequence	850004-850033	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP019483	Sinorhizobium meliloti strain B401 plasmid pSymA, complete sequence	460730-460759	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP019486	Sinorhizobium meliloti strain B399 plasmid pSymA, complete sequence	436543-436572	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NC_020527	Sinorhizobium meliloti 2011 plasmid pSymA, complete sequence	496374-496403	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NC_041921	Dinoroseobacter phage vB_DshS-R5C, complete genome	8620-8649	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NC_019848	Sinorhizobium meliloti GR4 plasmid pRmeGR4c, complete sequence	970511-970540	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NC_017327	Sinorhizobium meliloti SM11 plasmid pSmeSM11c, complete sequence	975853-975882	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP021798	Sinorhizobium meliloti strain USDA1106 plasmid psymA, complete sequence	220535-220564	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP009145	Sinorhizobium meliloti strain RMO17 plasmid pSymA, complete sequence	1018085-1018114	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP021801	Sinorhizobium meliloti strain USDA1021 plasmid psymA, complete sequence	924458-924487	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP021830	Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence	421875-421904	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP021824	Sinorhizobium meliloti strain KH46 plasmid psymA, complete sequence	901830-901859	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP021794	Sinorhizobium meliloti strain USDA1157 plasmid psymA, complete sequence	60795-60824	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP021809	Sinorhizobium meliloti strain Rm41 plasmid psymA, complete sequence	1397563-1397592	8	0.733
NZ_CP016824_20	20.3\|3778672\|30\|NZ_CP016824\|CRT	3778672-3778701	30	NZ_CP021217	Sinorhizobium meliloti RU11/001 plasmid pSymA, complete sequence	562250-562279	8	0.733
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NC_008242	Chelativorans sp. BNC1 plasmid 1, complete sequence	154695-154724	8	0.733
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NZ_CP017105	Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence	911597-911626	8	0.733
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NC_004719	Streptomyces avermitilis MA-4680 = NBRC 14893 plasmid SAP1, complete sequence	33110-33139	8	0.733
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NZ_CP017244	Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence	1273521-1273550	8	0.733
NZ_CP016824_20	20.5\|3778549\|32\|NZ_CP016824\|CRISPRCasFinder	3778549-3778580	32	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	866130-866161	8	0.75
NZ_CP016824_20	20.5\|3778549\|32\|NZ_CP016824\|CRISPRCasFinder	3778549-3778580	32	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	946993-947024	8	0.75
NZ_CP016824_20	20.6\|3778610\|32\|NZ_CP016824\|CRISPRCasFinder	3778610-3778641	32	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	866130-866161	8	0.75
NZ_CP016824_20	20.6\|3778610\|32\|NZ_CP016824\|CRISPRCasFinder	3778610-3778641	32	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	946993-947024	8	0.75
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP025431	Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence	169214-169245	8	0.75
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1873782-1873813	8	0.75
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	760170-760201	8	0.75
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NZ_CP049249	Rhizobium rhizoryzae strain DSM 29514 plasmid unnamed3, complete sequence	179112-179143	8	0.75
NZ_CP016824_24	24.2\|4202455\|32\|NZ_CP016824\|CRISPRCasFinder	4202455-4202486	32	NZ_CP037914	Sphingomonas sp. AAP5 plasmid p213, complete sequence	69804-69835	8	0.75
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NZ_CP016593	Ketogulonicigenium vulgare strain SKV plasmid pKvSKV1, complete sequence	266669-266701	8	0.758
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NC_017386	Ketogulonicigenium vulgare WSH-001 plasmid 1, complete sequence	201899-201931	8	0.758
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NC_014621	Ketogulonicigenium vulgare Y25 plasmid pYP1, complete sequence	168947-168979	8	0.758
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NZ_CP012909	Ketogulonicigenium vulgare strain Hbe602 plasmid 1, complete sequence	266708-266740	8	0.758
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NZ_CP016620	Microvirga ossetica strain V5/3m plasmid unnamed4, complete sequence	92779-92811	8	0.758
NZ_CP016824_36	36.1\|5688372\|34\|NZ_CP016824\|CRISPRCasFinder	5688372-5688405	34	NC_010335	Caulobacter sp. K31 plasmid pCAUL01, complete sequence	232268-232301	8	0.765
NZ_CP016824_38	38.1\|7051446\|32\|NZ_CP016824\|CRISPRCasFinder	7051446-7051477	32	NZ_LR134465	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence	158881-158912	8	0.75
NZ_CP016824_38	38.1\|7051446\|32\|NZ_CP016824\|CRISPRCasFinder	7051446-7051477	32	NZ_CP029359	Azospirillum sp. CFH 70021 plasmid unnamed4	61212-61243	8	0.75
NZ_CP016824_4	4.2\|1604612\|30\|NZ_CP016824\|CRISPRCasFinder	1604612-1604641	30	NZ_CP017076	Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence	1327396-1327425	9	0.7
NZ_CP016824_7	7.2\|2167041\|32\|NZ_CP016824\|CRISPRCasFinder	2167041-2167072	32	MT114163	Mycobacterium phage Settecandela, complete genome	28284-28315	9	0.719
NZ_CP016824_7	7.2\|2167041\|32\|NZ_CP016824\|CRISPRCasFinder	2167041-2167072	32	MK937592	Mycobacterium phage Phrappuccino, complete genome	28284-28315	9	0.719
NZ_CP016824_7	7.2\|2167041\|32\|NZ_CP016824\|CRISPRCasFinder	2167041-2167072	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	5816893-5816924	9	0.719
NZ_CP016824_7	7.2\|2167041\|32\|NZ_CP016824\|CRISPRCasFinder	2167041-2167072	32	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	1670455-1670486	9	0.719
NZ_CP016824_7	7.2\|2167041\|32\|NZ_CP016824\|CRISPRCasFinder	2167041-2167072	32	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	1956848-1956879	9	0.719
NZ_CP016824_7	7.2\|2167041\|32\|NZ_CP016824\|CRISPRCasFinder	2167041-2167072	32	NZ_CP016288	Rhizobium leguminosarum strain Vaf10 plasmid unnamed7, complete sequence	54360-54391	9	0.719
NZ_CP016824_7	7.2\|2167041\|32\|NZ_CP016824\|CRISPRCasFinder	2167041-2167072	32	NZ_CP054617	Azospirillum oryzae strain KACC 14407 plasmid unnamed3, complete sequence	446891-446922	9	0.719
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NC_016585	Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence	647725-647754	9	0.7
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	CP000876	Herpetosiphon aurantiacus DSM 785 plasmid pHAU01, complete sequence	79218-79247	9	0.7
NZ_CP016824_20	20.4\|3778733\|30\|NZ_CP016824\|CRT	3778733-3778762	30	NC_015741	Roseobacter litoralis Och 149 plasmid pRLO149_94, complete sequence	87099-87128	9	0.7
NZ_CP016824_20	20.5\|3778549\|32\|NZ_CP016824\|CRISPRCasFinder	3778549-3778580	32	NZ_CP050092	Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence	56403-56434	9	0.719
NZ_CP016824_20	20.5\|3778549\|32\|NZ_CP016824\|CRISPRCasFinder	3778549-3778580	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3988628-3988659	9	0.719
NZ_CP016824_20	20.5\|3778549\|32\|NZ_CP016824\|CRISPRCasFinder	3778549-3778580	32	NZ_CP021355	Rhodococcus sp. S2-17 plasmid pRB98, complete sequence	969790-969821	9	0.719
NZ_CP016824_20	20.6\|3778610\|32\|NZ_CP016824\|CRISPRCasFinder	3778610-3778641	32	NZ_CP050092	Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence	56403-56434	9	0.719
NZ_CP016824_20	20.6\|3778610\|32\|NZ_CP016824\|CRISPRCasFinder	3778610-3778641	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3988628-3988659	9	0.719
NZ_CP016824_20	20.6\|3778610\|32\|NZ_CP016824\|CRISPRCasFinder	3778610-3778641	32	NZ_CP021355	Rhodococcus sp. S2-17 plasmid pRB98, complete sequence	969790-969821	9	0.719
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP045120	Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence	155931-155962	9	0.719
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP016820	Rhodococcus sp. p52 plasmid pDF02, complete sequence	215821-215852	9	0.719
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP017941	Phyllobacterium zundukense strain Tri-48 plasmid unnamed1, complete sequence	362018-362049	9	0.719
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP015268	Mycobacterium chimaera strain ZUERICH-2 plasmid unnamed 1, complete sequence	138006-138037	9	0.719
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1245740-1245771	9	0.719
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP015279	Mycobacterium chimaera strain DSM 44623 plasmid unnamed 1, complete sequence	115743-115774	9	0.719
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP024310	Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence	826690-826721	9	0.719
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	588888-588919	9	0.719
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP023064	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence	647067-647098	9	0.719
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1523096-1523127	9	0.719
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1543498-1543529	9	0.719
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NC_008242	Chelativorans sp. BNC1 plasmid 1, complete sequence	154694-154725	9	0.719
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	MK737942	Microbacterium phage Sucha, complete genome	356-387	9	0.719
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	CP000876	Herpetosiphon aurantiacus DSM 785 plasmid pHAU01, complete sequence	79217-79248	9	0.719
NZ_CP016824_21	21.1\|3967952\|31\|NZ_CP016824\|CRISPRCasFinder	3967952-3967982	31	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	151945-151975	9	0.71
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NC_017588	Thermus thermophilus JL-18 plasmid pTTJL1801, complete sequence	123488-123520	9	0.727
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NZ_LR027520	Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence	276375-276407	9	0.727
NZ_CP016824_32	32.6\|5179626\|33\|NZ_CP016824\|CRISPRCasFinder	5179626-5179658	33	NZ_LR134455	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 13, complete sequence	20735-20767	9	0.727
NZ_CP016824_36	36.1\|5688372\|34\|NZ_CP016824\|CRISPRCasFinder	5688372-5688405	34	NZ_CP025805	Sulfitobacter sp. SK012 plasmid unnamed1, complete sequence	6300-6333	9	0.735
NZ_CP016824_36	36.1\|5688372\|34\|NZ_CP016824\|CRISPRCasFinder	5688372-5688405	34	NZ_CP025806	Sulfitobacter sp. SK012 plasmid unnamed3, complete sequence	101359-101392	9	0.735
NZ_CP016824_36	36.1\|5688372\|34\|NZ_CP016824\|CRISPRCasFinder	5688372-5688405	34	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	492871-492904	9	0.735
NZ_CP016824_36	36.1\|5688372\|34\|NZ_CP016824\|CRISPRCasFinder	5688372-5688405	34	NZ_CP031753	Rhodobacter sphaeroides strain EBL0706 plasmid p.B, complete sequence	86056-86089	9	0.735
NZ_CP016824_38	38.1\|7051446\|32\|NZ_CP016824\|CRISPRCasFinder	7051446-7051477	32	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	5104-5135	9	0.719
NZ_CP016824_38	38.1\|7051446\|32\|NZ_CP016824\|CRISPRCasFinder	7051446-7051477	32	NZ_CP027299	Streptomyces sp. SGAir0924 plasmid unnamed_5	133138-133169	9	0.719
NZ_CP016824_7	7.1\|2166980\|32\|NZ_CP016824\|CRISPRCasFinder	2166980-2167011	32	NC_007336	Cupriavidus pinatubonensis JMP134 megaplasmid, complete sequence	578778-578809	10	0.688
NZ_CP016824_7	7.1\|2166980\|32\|NZ_CP016824\|CRISPRCasFinder	2166980-2167011	32	MT708548	Streptomyces phage Salutena, complete genome	16636-16667	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NC_019848	Sinorhizobium meliloti GR4 plasmid pRmeGR4c, complete sequence	970510-970541	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NC_003037	Sinorhizobium meliloti 1021 plasmid pSymA, complete sequence	496713-496744	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP019585	Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymA, complete sequence	618631-618662	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NC_017327	Sinorhizobium meliloti SM11 plasmid pSmeSM11c, complete sequence	975852-975883	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP021798	Sinorhizobium meliloti strain USDA1106 plasmid psymA, complete sequence	220534-220565	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NC_017324	Sinorhizobium meliloti BL225C plasmid pSINMEB01, complete sequence	990244-990275	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP009145	Sinorhizobium meliloti strain RMO17 plasmid pSymA, complete sequence	1018084-1018115	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP021827	Sinorhizobium meliloti strain KH35c plasmid psymA, complete sequence	685106-685137	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP021801	Sinorhizobium meliloti strain USDA1021 plasmid psymA, complete sequence	924457-924488	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP021830	Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence	421874-421905	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP021824	Sinorhizobium meliloti strain KH46 plasmid psymA, complete sequence	901829-901860	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NC_018683	Sinorhizobium meliloti Rm41 plasmid pSYMA, complete sequence	777445-777476	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP021794	Sinorhizobium meliloti strain USDA1157 plasmid psymA, complete sequence	60794-60825	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP021809	Sinorhizobium meliloti strain Rm41 plasmid psymA, complete sequence	1397562-1397593	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP021805	Sinorhizobium meliloti strain T073 plasmid psymA, complete sequence	850003-850034	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP021217	Sinorhizobium meliloti RU11/001 plasmid pSymA, complete sequence	562249-562280	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP019483	Sinorhizobium meliloti strain B401 plasmid pSymA, complete sequence	460729-460760	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NZ_CP019486	Sinorhizobium meliloti strain B399 plasmid pSymA, complete sequence	436542-436573	10	0.688
NZ_CP016824_20	20.7\|3778671\|32\|NZ_CP016824\|CRISPRCasFinder	3778671-3778702	32	NC_020527	Sinorhizobium meliloti 2011 plasmid pSymA, complete sequence	496373-496404	10	0.688
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NC_004719	Streptomyces avermitilis MA-4680 = NBRC 14893 plasmid SAP1, complete sequence	33109-33140	10	0.688
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NZ_CP017105	Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence	911596-911627	10	0.688
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NZ_CP017244	Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence	1273520-1273551	10	0.688
NZ_CP016824_20	20.8\|3778732\|32\|NZ_CP016824\|CRISPRCasFinder	3778732-3778763	32	NC_015741	Roseobacter litoralis Och 149 plasmid pRLO149_94, complete sequence	87098-87129	10	0.688
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	10659-10691	10	0.697
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NZ_AP019802	Thermus thermophilus strain HC11 plasmid pHC11, complete sequence	17522-17554	10	0.697
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	MN234201	Mycobacterium phage Guanica15, complete genome	44459-44491	10	0.697
NZ_CP016824_36	36.1\|5688372\|34\|NZ_CP016824\|CRISPRCasFinder	5688372-5688405	34	NZ_LR134451	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 9, complete sequence	37139-37172	10	0.706
NZ_CP016824_36	36.1\|5688372\|34\|NZ_CP016824\|CRISPRCasFinder	5688372-5688405	34	NZ_CP040824	Paraoceanicella profunda strain D4M1 plasmid pD4M1F, complete sequence	80655-80688	10	0.706
NZ_CP016824_36	36.1\|5688372\|34\|NZ_CP016824\|CRISPRCasFinder	5688372-5688405	34	NZ_CP035513	Haematobacter massiliensis strain OT1 plasmid pOT1-3, complete sequence	245274-245307	10	0.706
NZ_CP016824_36	36.1\|5688372\|34\|NZ_CP016824\|CRISPRCasFinder	5688372-5688405	34	NZ_CP039965	Pseudorhodobacter sp. S12M18 plasmid unnamed1, complete sequence	1474205-1474238	10	0.706
NZ_CP016824_38	38.1\|7051446\|32\|NZ_CP016824\|CRISPRCasFinder	7051446-7051477	32	NZ_CP040820	Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence	276917-276948	10	0.688
NZ_CP016824_7	7.2\|2167041\|32\|NZ_CP016824\|CRISPRCasFinder	2167041-2167072	32	NC_010625	Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence	267957-267988	11	0.656
NZ_CP016824_32	32.4\|5179485\|42\|NZ_CP016824\|CRISPRCasFinder	5179485-5179526	42	NZ_CP030864	Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence	249601-249642	11	0.738
NZ_CP016824_32	32.5\|5179560\|33\|NZ_CP016824\|CRISPRCasFinder	5179560-5179592	33	NZ_CP054616	Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence	327811-327843	11	0.667
NZ_CP016824_22	22.1\|4021017\|40\|NZ_CP016824\|PILER-CR	4021017-4021056	40	KU530220	Streptomyces phage Xkcd426, complete genome	29731-29770	12	0.7

1. spacer 33.2|5179932|21|NZ_CP016824|CRISPRCasFinder matches to NZ_CP027023 (Streptomyces sp. WAC00288 plasmid p1, complete sequence) position: , mismatch: 1, identity: 0.952

ggcccgctcccgctccgcgtg	CRISPR spacer
ggcccgctcccgctccgcctg	Protospacer
****************** **

2. spacer 31.1|5175228|24|NZ_CP016824|PILER-CR matches to NZ_CP040453 (Halomonas sp. PA16-9 plasmid p_unnamed2, complete sequence) position: , mismatch: 2, identity: 0.917

atcgaggggtgctggtcggtgccg	CRISPR spacer
atcgagaggtgctgctcggtgccg	Protospacer
******.******* *********

3. spacer 31.1|5175228|24|NZ_CP016824|PILER-CR matches to NZ_CP029835 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed5, complete sequence) position: , mismatch: 4, identity: 0.833

atcgaggggtgctggtcggtgccg	CRISPR spacer
gggaaggggtgctggtcggtgccg	Protospacer
.  .********************

4. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NZ_JX627580 (Methylobacterium oryzae CBMB20 plasmid pMOC1, complete sequence) position: , mismatch: 4, identity: 0.879

cgcctcggtcaccgtccgctcggcctcggcccg--	CRISPR spacer
cgcctcggtctccgtccgctcggc--cggcgcgac	Protospacer
********** *************  **** **

5. spacer 11.2|2661373|27|NZ_CP016824|PILER-CR matches to NZ_CP016293 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed5, complete sequence) position: , mismatch: 5, identity: 0.815

ggtgaccggcacggtcagacgtgtccg	CRISPR spacer
ggtgaccggcagtgtcagacgtgtatt	Protospacer
***********  *********** .

6. spacer 20.1|3778550|30|NZ_CP016824|CRT matches to MF477236 (Nocardia phage NTR1, complete genome) position: , mismatch: 5, identity: 0.833

-gagcaggacccggtgcgcccggtcggagag	CRISPR spacer
cgcgc-ggacccggtgcgccgggtcggaccg	Protospacer
 * ** ************** *******  *

7. spacer 20.2|3778611|30|NZ_CP016824|CRT matches to MF477236 (Nocardia phage NTR1, complete genome) position: , mismatch: 5, identity: 0.833

-gagcaggacccggtgcgcccggtcggagag	CRISPR spacer
cgcgc-ggacccggtgcgccgggtcggaccg	Protospacer
 * ** ************** *******  *

8. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NZ_CP015737 (Shinella sp. HZN7 plasmid pShin-01, complete sequence) position: , mismatch: 5, identity: 0.833

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
gcggcgcggtgccatcggcatcgccgtcgg	Protospacer
 ************** ******* ****

9. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NZ_CP025810 (Sulfitobacter sp. SK025 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.833

ccggcgc-ggtgccatgggcatcggcgtcct	CRISPR spacer
-cgccgtaggggccatgggcatcggcgacct	Protospacer
 ** **. ** **************** ***

10. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP025014 (Rhizobium leguminosarum strain Norway plasmid pRLN2, complete sequence) position: , mismatch: 5, identity: 0.844

-cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gcgatc-gccgcgccgatatcaccggcagcgcc	Protospacer
 **.** **********. *************.

11. spacer 7.2|2167041|32|NZ_CP016824|CRISPRCasFinder matches to NC_017805 (Deinococcus gobiensis I-0 plasmid P1, complete sequence) position: , mismatch: 6, identity: 0.812

cgctggctgctcgacccgcaggcgacggcgaa--	CRISPR spacer
cgctggctgcgtgacccgcaggc--cgtcaaacc	Protospacer
********** .***********  ** *.**

12. spacer 7.3|2167102|32|NZ_CP016824|CRISPRCasFinder matches to LR134125 (Klebsiella aerogenes strain NCTC10006 genome assembly, plasmid: 5) position: , mismatch: 6, identity: 0.812

acgccggcggcgaccgcgcagg-tttcgccttg	CRISPR spacer
ccgccggcggcgagcacgcaggttttcgcggt-	Protospacer
 ************ *.****** ******  *

13. spacer 18.1|3474385|28|NZ_CP016824|PILER-CR matches to NZ_CP020717 (Cnuibacter physcomitrellae strain XA(T) plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.786

cggctgcgggcgctagctccgcgctcgc	CRISPR spacer
gcaccgcgggcgatagctccgcgttcgc	Protospacer
  .*.******* **********.****

14. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP025014 (Rhizobium leguminosarum strain Norway plasmid pRLN2, complete sequence) position: , mismatch: 6, identity: 0.8

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
cgatcgccgcgccgatatcaccggcagcgc	Protospacer
 * . **********. *************

15. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP025431 (Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence) position: , mismatch: 6, identity: 0.8

--ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ataatc--ccgcgccgccctcaccggcggcgc	Protospacer
  ..**  ******** **********.****

16. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 6, identity: 0.8

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggccgcccgcgccgacctcaccgccggcgt	Protospacer
**.*. ***************** *.***.

17. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.8

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
gatcagccccgccgacctcgccggcggatc	Protospacer
*.****** **********.*****.*  *

18. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to MK880124 (Microbacterium phage IAmGroot, complete genome) position: , mismatch: 6, identity: 0.8

ggtcagccgcgccgacctcaccggcagcgc--	CRISPR spacer
tctcacccgcgccgacctcaccg--agctccg	Protospacer
  *** *****************  *** *

19. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NC_016624 (Azospirillum lipoferum 4B plasmid AZO_p5, complete sequence) position: , mismatch: 6, identity: 0.8

--ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
cctgtcgg--gcgccgacctcagcggcagcga	Protospacer
   ***.*  ************ ********

20. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NZ_CP049249 (Rhizobium rhizoryzae strain DSM 29514 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.8

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
aatgcgcgttgccatgggcatcgccgtctt	Protospacer
   ***** ************** ****.*

21. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NZ_CP010408 (Streptomyces vietnamensis strain GIMV4.0001 plasmid pSVL1, complete sequence) position: , mismatch: 6, identity: 0.8

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
ccacgacggtcccatgggcatcggcatcct	Protospacer
**.  .**** **************.****

22. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NZ_CP010626 (Phaeobacter inhibens strain P51 plasmid pP51_c, complete sequence) position: , mismatch: 6, identity: 0.8

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
gctgcgcggtgccaccggcatcggcgcact	Protospacer
 * ***********. **********. **

23. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NZ_CP010671 (Phaeobacter inhibens strain P57 plasmid pP57_c, complete sequence) position: , mismatch: 6, identity: 0.8

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
gctgcgcggtgccaccggcatcggcgcact	Protospacer
 * ***********. **********. **

24. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NZ_CP010744 (Phaeobacter inhibens strain P59 plasmid pP59_c, complete sequence) position: , mismatch: 6, identity: 0.8

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
gctgcgcggtgccaccggcatcggcgcact	Protospacer
 * ***********. **********. **

25. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NZ_CP010622 (Phaeobacter inhibens strain P30 isolate M4-3.1A plasmid pP30_e, complete sequence) position: , mismatch: 6, identity: 0.8

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
gctgcgcggtgccaccggcatcggcgcact	Protospacer
 * ***********. **********. **

26. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NZ_CP010702 (Phaeobacter inhibens strain P24 plasmid pP24_f, complete sequence) position: , mismatch: 6, identity: 0.8

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
gctgcgcggtgccaccggcatcggcgcact	Protospacer
 * ***********. **********. **

27. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NZ_CP010748 (Phaeobacter inhibens strain P48 isolate M21-2.3 plasmid pP48_c, complete sequence) position: , mismatch: 6, identity: 0.8

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
gctgcgcggtgccaccggcatcggcgcact	Protospacer
 * ***********. **********. **

28. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP015737 (Shinella sp. HZN7 plasmid pShin-01, complete sequence) position: , mismatch: 6, identity: 0.812

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
cgcggcgcggtgccatcggcatcgccgtcggc	Protospacer
. ************** ******* ****  *

29. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP025810 (Sulfitobacter sp. SK025 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.812

tccggcgc----ggtgccatgggcatcggcgtcctc	CRISPR spacer
----gcgccgtaggggccatgggcatcggcgacctc	Protospacer
    ****    ** **************** ****

30. spacer 25.1|4214981|30|NZ_CP016824|PILER-CR matches to NZ_CP013855 (Pseudonocardia sp. HH130630-07 plasmid pLS2-1, complete sequence) position: , mismatch: 6, identity: 0.8

ggcacggtcgagacggagcccggcaatcga--	CRISPR spacer
ttcaccgtcgagaccgagcccggca--cgacc	Protospacer
  *** ******** **********  ***

31. spacer 25.1|4214981|30|NZ_CP016824|PILER-CR matches to NC_023724 (Mycobacterium phage Larva, complete genome) position: , mismatch: 6, identity: 0.8

ggcacggtcgagacggagcccggcaatcga	CRISPR spacer
ggcacggtcgagcaggagcccgggcagcca	Protospacer
************  *********  * * *

32. spacer 25.1|4214981|30|NZ_CP016824|PILER-CR matches to MF185717 (Mycobacterium phage AlleyCat, complete genome) position: , mismatch: 6, identity: 0.8

ggcacggtcgagacggagcccggcaatcga	CRISPR spacer
ggcacggtcgagcaggagcccgggcagcca	Protospacer
************  *********  * * *

33. spacer 32.3|5179419|33|NZ_CP016824|CRISPRCasFinder matches to NZ_CP025986 (Ralstonia solanacearum strain RSCM plasmid p-unname2, complete sequence) position: , mismatch: 6, identity: 0.818

tgcctgcgaggtcagttcctcggccgcggccag	CRISPR spacer
tccctgcgagcgcagttcctcggccgcgtcgat	Protospacer
* ********  **************** * *

34. spacer 32.3|5179419|33|NZ_CP016824|CRISPRCasFinder matches to NZ_CP019938 (Ketogulonicigenium robustum strain SPU_B003 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.818

--tgcctgcgaggtcagttcctcggccgcggccag	CRISPR spacer
ggtgacggc--ggccagttcctcggcctcggccag	Protospacer
  ** * **  **.************* *******

35. spacer 32.6|5179626|33|NZ_CP016824|CRISPRCasFinder matches to NZ_CP018784 (Curtobacterium pusillum strain AA3 plasmid pCPAA3, complete sequence) position: , mismatch: 6, identity: 0.818

ggaacg-cgcccccagcgactcggcctccgtggc	CRISPR spacer
-caacgccgcctcgagcgactcggcctccgtcac	Protospacer
  **** ****.* ***************** .*

36. spacer 36.1|5688372|34|NZ_CP016824|CRISPRCasFinder matches to NZ_CP029833 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.824

ggatcgatcccgccgccccgcgccccgccgatgc-	CRISPR spacer
ggctcgatctcgccgccccgcg-cccgctggagcc	Protospacer
** ******.************ *****.*. **

37. spacer 38.1|7051446|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP034351 (Streptomyces sp. W1SF4 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.812

-tggtgtgcgcggaggccgcgggccgggtgcgg	CRISPR spacer
taggtgt-cgcgggggccgcgggcggggtgctt	Protospacer
  ***** *****.********** ******

38. spacer 4.2|1604612|30|NZ_CP016824|CRISPRCasFinder matches to MH045568 (Microbacterium phage Kieran, complete genome) position: , mismatch: 7, identity: 0.767

aaccagcccggccggcgcttgaggccaaac	CRISPR spacer
gacccgcccggccggcgcatgaggccgtcg	Protospacer
.*** ************* *******.

39. spacer 4.2|1604612|30|NZ_CP016824|CRISPRCasFinder matches to MN062717 (Microbacterium phage Sharkboy, complete genome) position: , mismatch: 7, identity: 0.767

aaccagcccggccggcgcttgaggccaaac	CRISPR spacer
gacccgcccggccggcgcatgaggccgtcg	Protospacer
.*** ************* *******.

40. spacer 4.2|1604612|30|NZ_CP016824|CRISPRCasFinder matches to MT310853 (Microbacterium phage AvGardian, complete genome) position: , mismatch: 7, identity: 0.767

aaccagcccggccggcgcttgaggccaaac	CRISPR spacer
gacccgcccggccggcgcatgaggccgtcg	Protospacer
.*** ************* *******.

41. spacer 4.2|1604612|30|NZ_CP016824|CRISPRCasFinder matches to NC_042099 (Microbacterium phage Dismas, complete genome) position: , mismatch: 7, identity: 0.767

aaccagcccggccggcgcttgaggccaaac	CRISPR spacer
gacccgcccggccggcgcatgaggccgtcg	Protospacer
.*** ************* *******.

42. spacer 4.2|1604612|30|NZ_CP016824|CRISPRCasFinder matches to NZ_LN832562 (Paracoccus aminovorans isolate JCM7685 plasmid IV, complete sequence) position: , mismatch: 7, identity: 0.767

aaccagcccggccggcgcttgaggccaaac	CRISPR spacer
aggcggcccgggcggggcttgaggccaagg	Protospacer
*. *.****** *** ************.

43. spacer 20.1|3778550|30|NZ_CP016824|CRT matches to NZ_CP050092 (Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence) position: , mismatch: 7, identity: 0.767

gagcaggacccggtgcgcccggtcggagag	CRISPR spacer
ggggccaacccggtccgcccggtcggatag	Protospacer
*.*   .******* ************ **

44. spacer 20.2|3778611|30|NZ_CP016824|CRT matches to NZ_CP050092 (Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence) position: , mismatch: 7, identity: 0.767

gagcaggacccggtgcgcccggtcggagag	CRISPR spacer
ggggccaacccggtccgcccggtcggatag	Protospacer
*.*   .******* ************ **

45. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP016820 (Rhodococcus sp. p52 plasmid pDF02, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
tctcagccgcgcagacctgaccggcacgga	Protospacer
  ********** ***** *******  *

46. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP045120 (Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
cgtcggccgcgccgccctcaccggccagga	Protospacer
 ***.********* ********** . *

47. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP015268 (Mycobacterium chimaera strain ZUERICH-2 plasmid unnamed 1, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
gggtgcgcgcgccgacctcatcgacagcgc	Protospacer
** ..  *************.**.******

48. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
gcccgaccgctccgaccccaccggcagcgg	Protospacer
* .*..**** ******.***********

49. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP024310 (Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
tctctaccgcgccgaccgcaccggccgcga	Protospacer
  ** .*********** ******* ***

50. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
gcccgaccgctccgaccccaccggcagcgg	Protospacer
* .*..**** ******.***********

51. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP023064 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
tctctaccgcgccgaccgcaccggccgcga	Protospacer
  ** .*********** ******* ***

52. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
gcccgaccgctccgaccccaccggcagcgg	Protospacer
* .*..**** ******.***********

53. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP017941 (Phyllobacterium zundukense strain Tri-48 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
aatcgcgcgcgccgacctcaccgaaagcgc	Protospacer
..**.  ****************. *****

54. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP015279 (Mycobacterium chimaera strain DSM 44623 plasmid unnamed 1, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
gggtgcgcgcgccgacctcatcgacagcgc	Protospacer
** ..  *************.**.******

55. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
gcccgaccgctccgaccccaccggcagcgg	Protospacer
* .*..**** ******.***********

56. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_LR134463 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 21, complete sequence) position: , mismatch: 7, identity: 0.781

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
cgagctccggcgccgacctcaacggcggcgct	Protospacer
**. *  * ************ ****.*****

57. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP010408 (Streptomyces vietnamensis strain GIMV4.0001 plasmid pSVL1, complete sequence) position: , mismatch: 7, identity: 0.781

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
cccacgacggtcccatgggcatcggcatcctc	Protospacer
.**.  .**** **************.*****

58. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP010626 (Phaeobacter inhibens strain P51 plasmid pP51_c, complete sequence) position: , mismatch: 7, identity: 0.781

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
tgctgcgcggtgccaccggcatcggcgcactg	Protospacer
* * ***********. **********. **

59. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP010671 (Phaeobacter inhibens strain P57 plasmid pP57_c, complete sequence) position: , mismatch: 7, identity: 0.781

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
tgctgcgcggtgccaccggcatcggcgcactg	Protospacer
* * ***********. **********. **

60. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP010744 (Phaeobacter inhibens strain P59 plasmid pP59_c, complete sequence) position: , mismatch: 7, identity: 0.781

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
tgctgcgcggtgccaccggcatcggcgcactg	Protospacer
* * ***********. **********. **

61. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP010622 (Phaeobacter inhibens strain P30 isolate M4-3.1A plasmid pP30_e, complete sequence) position: , mismatch: 7, identity: 0.781

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
tgctgcgcggtgccaccggcatcggcgcactg	Protospacer
* * ***********. **********. **

62. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP010702 (Phaeobacter inhibens strain P24 plasmid pP24_f, complete sequence) position: , mismatch: 7, identity: 0.781

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
tgctgcgcggtgccaccggcatcggcgcactg	Protospacer
* * ***********. **********. **

63. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP010748 (Phaeobacter inhibens strain P48 isolate M21-2.3 plasmid pP48_c, complete sequence) position: , mismatch: 7, identity: 0.781

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
tgctgcgcggtgccaccggcatcggcgcactg	Protospacer
* * ***********. **********. **

64. spacer 21.1|3967952|31|NZ_CP016824|CRISPRCasFinder matches to MH045568 (Microbacterium phage Kieran, complete genome) position: , mismatch: 7, identity: 0.774

ctttggcctcaagcgccggccgggctggttt	CRISPR spacer
cgacggcctcatgcgccggccgggcgggtcg	Protospacer
*  .******* ************* ***.

65. spacer 21.1|3967952|31|NZ_CP016824|CRISPRCasFinder matches to MN062717 (Microbacterium phage Sharkboy, complete genome) position: , mismatch: 7, identity: 0.774

ctttggcctcaagcgccggccgggctggttt	CRISPR spacer
cgacggcctcatgcgccggccgggcgggtcg	Protospacer
*  .******* ************* ***.

66. spacer 21.1|3967952|31|NZ_CP016824|CRISPRCasFinder matches to MT310853 (Microbacterium phage AvGardian, complete genome) position: , mismatch: 7, identity: 0.774

ctttggcctcaagcgccggccgggctggttt	CRISPR spacer
cgacggcctcatgcgccggccgggcgggtcg	Protospacer
*  .******* ************* ***.

67. spacer 21.1|3967952|31|NZ_CP016824|CRISPRCasFinder matches to NC_042099 (Microbacterium phage Dismas, complete genome) position: , mismatch: 7, identity: 0.774

ctttggcctcaagcgccggccgggctggttt	CRISPR spacer
cgacggcctcatgcgccggccgggcgggtcg	Protospacer
*  .******* ************* ***.

68. spacer 21.1|3967952|31|NZ_CP016824|CRISPRCasFinder matches to NZ_LN832562 (Paracoccus aminovorans isolate JCM7685 plasmid IV, complete sequence) position: , mismatch: 7, identity: 0.774

ctttggcctcaagcgccggccgggctggttt	CRISPR spacer
ccttggcctcaagccccgcccgggccgcctc	Protospacer
*.************ *** ******.* .*.

69. spacer 25.1|4214981|30|NZ_CP016824|PILER-CR matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 7, identity: 0.767

ggcacggtcgagacggagcccggcaatcga-	CRISPR spacer
tgcacggtcgagacggagcacga-gatcatt	Protospacer
 ****************** **. .***.

70. spacer 25.1|4214981|30|NZ_CP016824|PILER-CR matches to NZ_CP016617 (Microvirga ossetica strain V5/3m plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

ggcacggtcgagacggagcccggcaatcga	CRISPR spacer
agcatggtcgagaccgagcccggcgagctg	Protospacer
.***.********* *********.* * .

71. spacer 26.1|4595263|54|NZ_CP016824|CRISPRCasFinder matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.87

cgccggggcgcggctgcgccggcagggcgtggagcgcgtccgcatcgtggagac	CRISPR spacer
cgccggggcgcggctgcgccggcagggcgtggaacgcgtccgcctgatcgacaa	Protospacer
*********************************.********* * .* ** *

72. spacer 32.3|5179419|33|NZ_CP016824|CRISPRCasFinder matches to CP054924 (Verrucosispora sp. NA02020 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.788

tgcctgcgaggtcagttcctcggccgcggccag	CRISPR spacer
cgtctccgaggtcaggtcctcggccgcctcccg	Protospacer
.*.** ********* ***********  ** *

73. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NC_016585 (Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence) position: , mismatch: 7, identity: 0.788

cgcctcggtcaccgtccgctcggcctcggcccg	CRISPR spacer
ggcggcggtcgccgtccgcacggcctcggccat	Protospacer
 **  *****.******** ***********

74. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NZ_CP040761 (Paracoccus sp. 2251 plasmid unnamed5, complete sequence) position: , mismatch: 7, identity: 0.788

cgcctcggtcaccgtccgctcggcctcggcccg	CRISPR spacer
cgaggcgcgcacgatccgctcggcctcggcccg	Protospacer
**   **  *** .*******************

75. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NZ_LR134463 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 21, complete sequence) position: , mismatch: 7, identity: 0.788

-----cgcctcggtcaccgtccgctcggcctcggcccg	CRISPR spacer
tcaggcgcc-----caccgtccgcgcgacctcggcccg	Protospacer
     ****     ********** **.**********

76. spacer 38.1|7051446|32|NZ_CP016824|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 7, identity: 0.781

tggtgtgcgcggaggccgcgggccgggtgcgg	CRISPR spacer
cggtgtacgcggacgccgcgggccagtgacgg	Protospacer
.*****.****** **********.*  .***

77. spacer 4.2|1604612|30|NZ_CP016824|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 8, identity: 0.733

aaccagcccggccggcgcttgaggccaaac	CRISPR spacer
ccgaagcccggccggcgaatgaggccatat	Protospacer
    *************  ******** *.

78. spacer 7.1|2166980|32|NZ_CP016824|CRISPRCasFinder matches to MH727545 (Mycobacterium phage DismalStressor, complete genome) position: , mismatch: 8, identity: 0.75

aaccccatcaagctgagcgacgtcgacccgac	CRISPR spacer
gaccgcatcgagctgagcgacgtcgagcgcca	Protospacer
.*** ****.**************** *

79. spacer 7.1|2166980|32|NZ_CP016824|CRISPRCasFinder matches to NC_026598 (Mycobacterium phage Milly, complete genome) position: , mismatch: 8, identity: 0.75

aaccccatcaagctgagcgacgtcgacccgac	CRISPR spacer
gaccgcatcgagctgagcgacgtcgagcgcca	Protospacer
.*** ****.**************** *

80. spacer 7.1|2166980|32|NZ_CP016824|CRISPRCasFinder matches to MH834601 (Mycobacterium phage BoostSeason, complete genome) position: , mismatch: 8, identity: 0.75

aaccccatcaagctgagcgacgtcgacccgac	CRISPR spacer
gaccgcatcgagctgagcgacgtcgagcgcca	Protospacer
.*** ****.**************** *

81. spacer 7.1|2166980|32|NZ_CP016824|CRISPRCasFinder matches to KX688047 (Mycobacterium phage Marcoliusprime, complete genome) position: , mismatch: 8, identity: 0.75

aaccccatcaagctgagcgacgtcgacccgac	CRISPR spacer
gaccgcatcgagctgagcgacgtcgagcgcca	Protospacer
.*** ****.**************** *

82. spacer 7.1|2166980|32|NZ_CP016824|CRISPRCasFinder matches to NC_028759 (Mycobacterium phage Mufasa, complete genome) position: , mismatch: 8, identity: 0.75

aaccccatcaagctgagcgacgtcgacccgac	CRISPR spacer
gaccgcatcgagctgagcgacgtcgagcgcca	Protospacer
.*** ****.**************** *

83. spacer 7.1|2166980|32|NZ_CP016824|CRISPRCasFinder matches to MF140408 (Mycobacterium phage DismalFunk, complete genome) position: , mismatch: 8, identity: 0.75

aaccccatcaagctgagcgacgtcgacccgac	CRISPR spacer
gaccgcatcgagctgagcgacgtcgagcgcca	Protospacer
.*** ****.**************** *

84. spacer 7.1|2166980|32|NZ_CP016824|CRISPRCasFinder matches to MF140411 (Mycobacterium phage Findley, complete genome) position: , mismatch: 8, identity: 0.75

aaccccatcaagctgagcgacgtcgacccgac	CRISPR spacer
gaccgcatcgagctgagcgacgtcgagcgcca	Protospacer
.*** ****.**************** *

85. spacer 7.3|2167102|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP048789 (Roseobacter ponti strain DSM 106830 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.75

acgccggcggcgaccgcgcaggtttcgccttg	CRISPR spacer
acgccggcggcgaccgcgcggtttgcccgcac	Protospacer
*******************.* ** * * .

86. spacer 7.3|2167102|32|NZ_CP016824|CRISPRCasFinder matches to CP003953 (Rhodococcus opacus PD630 plasmid 4, complete sequence) position: , mismatch: 8, identity: 0.75

acgccggcggcgaccgcgcaggtttcgccttg	CRISPR spacer
gctccggcggtgaccgtgcaggtttcgaggtc	Protospacer
.* *******.*****.**********   *

87. spacer 7.3|2167102|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 8, identity: 0.75

acgccggcggcgaccgcgcaggtttcgccttg	CRISPR spacer
attccggcggcgaccgcgctggtctcccgcag	Protospacer
*. **************** ***.** * . *

88. spacer 7.3|2167102|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.75

acgccggcggcgaccgcgcaggtttcgccttg	CRISPR spacer
attccggcggccaccgcgctggtttcccgcag	Protospacer
*. ******** ******* ****** * . *

89. spacer 7.3|2167102|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP038636 (Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

acgccggcggcgaccgcgcaggtttcgccttg	CRISPR spacer
ctgaccgcggcgaccgcacaggttgcgccgcg	Protospacer
 .* * ***********.****** **** .*

90. spacer 7.3|2167102|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 8, identity: 0.75

acgccggcggcgaccgcgcaggtttcgccttg	CRISPR spacer
attccggcggccaccgcgctggtttcccgcag	Protospacer
*. ******** ******* ****** * . *

91. spacer 18.1|3474385|28|NZ_CP016824|PILER-CR matches to NZ_CP049322 (Caballeronia sp. SBC2 plasmid pSBC2-6, complete sequence) position: , mismatch: 8, identity: 0.714

cggctgcgggcgctagctccgcgctcgc	CRISPR spacer
tcaaacagggcggtagctccgcgctcgc	Protospacer
. .    ***** ***************

92. spacer 20.1|3778550|30|NZ_CP016824|CRT matches to NC_014159 (Tsukamurella paurometabola DSM 20162 plasmid pTpau01, complete sequence) position: , mismatch: 8, identity: 0.733

gagcaggacccggtgcgcccggtcggagag	CRISPR spacer
gcagcggacccggtgcgcccggtcggtacc	Protospacer
* .  ********************* .

93. spacer 20.1|3778550|30|NZ_CP016824|CRT matches to MT114163 (Mycobacterium phage Settecandela, complete genome) position: , mismatch: 8, identity: 0.733

gagcaggacccggtgcgcccggtcggagag	CRISPR spacer
tggtcggacccggtgcgcgcggtcggcgcc	Protospacer
 .*. ************* ******* *

94. spacer 20.1|3778550|30|NZ_CP016824|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 8, identity: 0.733

gagcaggacccggtgcgcccggtcggagag	CRISPR spacer
tggcaggacccggtgcccgcggtcgaccac	Protospacer
 .************** * ******.  *

95. spacer 20.1|3778550|30|NZ_CP016824|CRT matches to NZ_CP021355 (Rhodococcus sp. S2-17 plasmid pRB98, complete sequence) position: , mismatch: 8, identity: 0.733

gagcaggacccggtgcgcccggtcggagag	CRISPR spacer
aaggagtacccggtgcgcccggtcccggcc	Protospacer
.** ** *****************  .*

96. spacer 20.2|3778611|30|NZ_CP016824|CRT matches to NC_014159 (Tsukamurella paurometabola DSM 20162 plasmid pTpau01, complete sequence) position: , mismatch: 8, identity: 0.733

gagcaggacccggtgcgcccggtcggagag	CRISPR spacer
gcagcggacccggtgcgcccggtcggtacc	Protospacer
* .  ********************* .

97. spacer 20.2|3778611|30|NZ_CP016824|CRT matches to MT114163 (Mycobacterium phage Settecandela, complete genome) position: , mismatch: 8, identity: 0.733

gagcaggacccggtgcgcccggtcggagag	CRISPR spacer
tggtcggacccggtgcgcgcggtcggcgcc	Protospacer
 .*. ************* ******* *

98. spacer 20.2|3778611|30|NZ_CP016824|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 8, identity: 0.733

gagcaggacccggtgcgcccggtcggagag	CRISPR spacer
tggcaggacccggtgcccgcggtcgaccac	Protospacer
 .************** * ******.  *

99. spacer 20.2|3778611|30|NZ_CP016824|CRT matches to NZ_CP021355 (Rhodococcus sp. S2-17 plasmid pRB98, complete sequence) position: , mismatch: 8, identity: 0.733

gagcaggacccggtgcgcccggtcggagag	CRISPR spacer
aaggagtacccggtgcgcccggtcccggcc	Protospacer
.** ** *****************  .*

100. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NC_003037 (Sinorhizobium meliloti 1021 plasmid pSymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

101. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP019585 (Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatag	Protospacer
****** *************.** * ...

102. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NC_017324 (Sinorhizobium meliloti BL225C plasmid pSINMEB01, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

103. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP021827 (Sinorhizobium meliloti strain KH35c plasmid psymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

104. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NC_018683 (Sinorhizobium meliloti Rm41 plasmid pSYMA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

105. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP021805 (Sinorhizobium meliloti strain T073 plasmid psymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

106. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP019483 (Sinorhizobium meliloti strain B401 plasmid pSymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

107. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP019486 (Sinorhizobium meliloti strain B399 plasmid pSymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

108. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NC_020527 (Sinorhizobium meliloti 2011 plasmid pSymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

109. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NC_041921 (Dinoroseobacter phage vB_DshS-R5C, complete genome) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
gcacgagggcgccgacctcaccggcatcgt	Protospacer
*  *..  ****************** **.

110. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NC_019848 (Sinorhizobium meliloti GR4 plasmid pRmeGR4c, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

111. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NC_017327 (Sinorhizobium meliloti SM11 plasmid pSmeSM11c, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

112. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP021798 (Sinorhizobium meliloti strain USDA1106 plasmid psymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

113. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP009145 (Sinorhizobium meliloti strain RMO17 plasmid pSymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

114. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP021801 (Sinorhizobium meliloti strain USDA1021 plasmid psymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

115. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP021830 (Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

116. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP021824 (Sinorhizobium meliloti strain KH46 plasmid psymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

117. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP021794 (Sinorhizobium meliloti strain USDA1157 plasmid psymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

118. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP021809 (Sinorhizobium meliloti strain Rm41 plasmid psymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

119. spacer 20.3|3778672|30|NZ_CP016824|CRT matches to NZ_CP021217 (Sinorhizobium meliloti RU11/001 plasmid pSymA, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcagccgcgccgacctcaccggcagcgc	CRISPR spacer
ggtcagacgcgccgacctcatcgtccatcg	Protospacer
****** *************.** * ..

120. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NC_008242 (Chelativorans sp. BNC1 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.733

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
gcggcgcggcgccatcggcatcggccgttc	Protospacer
 ********.***** *********  ...

121. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NZ_CP017105 (Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence) position: , mismatch: 8, identity: 0.733

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
ctggctcggtgccatggccatcggcccgga	Protospacer
*.*** *********** ******* .

122. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NC_004719 (Streptomyces avermitilis MA-4680 = NBRC 14893 plasmid SAP1, complete sequence) position: , mismatch: 8, identity: 0.733

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
cgtgcgcggtgcccagggcatcggcgatgc	Protospacer
*  **********  *********** . .

123. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NZ_CP017244 (Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence) position: , mismatch: 8, identity: 0.733

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
ctggctcggtgccatggccatcggcccgga	Protospacer
*.*** *********** ******* .

124. spacer 20.5|3778549|32|NZ_CP016824|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 8, identity: 0.75

cgagcaggacccggtgcgcccgg-----tcggagagc	CRISPR spacer
cgagccggccccggtgcgcccggggcctgcgg-----	Protospacer
***** ** **************      ***

125. spacer 20.5|3778549|32|NZ_CP016824|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 8, identity: 0.75

cgagcaggacccggtgcgcccgg-----tcggagagc	CRISPR spacer
cgagccggccccggtgcgcccggggcctgcgg-----	Protospacer
***** ** **************      ***

126. spacer 20.6|3778610|32|NZ_CP016824|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 8, identity: 0.75

cgagcaggacccggtgcgcccgg-----tcggagagc	CRISPR spacer
cgagccggccccggtgcgcccggggcctgcgg-----	Protospacer
***** ** **************      ***

127. spacer 20.6|3778610|32|NZ_CP016824|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 8, identity: 0.75

cgagcaggacccggtgcgcccgg-----tcggagagc	CRISPR spacer
cgagccggccccggtgcgcccggggcctgcgg-----	Protospacer
***** ** **************      ***

128. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP025431 (Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence) position: , mismatch: 8, identity: 0.75

--cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gataatc--ccgcgccgccctcaccggcggcgcg	Protospacer
  ...**  ******** **********.****

129. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 8, identity: 0.75

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
aggccgcccgcgccgacctcaccgccggcgtc	Protospacer
 **.*. ***************** *.***..

130. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.75

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
agatcagccccgccgacctcgccggcggatcg	Protospacer
 *.****** **********.*****.*  *

131. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP049249 (Rhizobium rhizoryzae strain DSM 29514 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.75

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
aaatgcgcgttgccatgggcatcgccgtcttt	Protospacer
    ***** ************** ****.*.

132. spacer 24.2|4202455|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP037914 (Sphingomonas sp. AAP5 plasmid p213, complete sequence) position: , mismatch: 8, identity: 0.75

cggtggatgtggaagctcatctacctgtgcac	CRISPR spacer
tggtggatgtggaagctcatccacatttattt	Protospacer
.********************.** * *.. .

133. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NZ_CP016593 (Ketogulonicigenium vulgare strain SKV plasmid pKvSKV1, complete sequence) position: , mismatch: 8, identity: 0.758

cgcctcgg---tcaccgtccgctcggcctcggcccg	CRISPR spacer
---atcgaaatgcacggtcagctcggcctcggcccg	Protospacer
    ***.    *** *** ****************

134. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NC_017386 (Ketogulonicigenium vulgare WSH-001 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.758

cgcctcgg---tcaccgtccgctcggcctcggcccg	CRISPR spacer
---atcgaaatgcacggtcagctcggcctcggcccg	Protospacer
    ***.    *** *** ****************

135. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NC_014621 (Ketogulonicigenium vulgare Y25 plasmid pYP1, complete sequence) position: , mismatch: 8, identity: 0.758

cgcctcgg---tcaccgtccgctcggcctcggcccg	CRISPR spacer
---atcgaaatgcacggtcagctcggcctcggcccg	Protospacer
    ***.    *** *** ****************

136. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NZ_CP012909 (Ketogulonicigenium vulgare strain Hbe602 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.758

cgcctcgg---tcaccgtccgctcggcctcggcccg	CRISPR spacer
---atcgaaatgcacggtcagctcggcctcggcccg	Protospacer
    ***.    *** *** ****************

137. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NZ_CP016620 (Microvirga ossetica strain V5/3m plasmid unnamed4, complete sequence) position: , mismatch: 8, identity: 0.758

cgcctcggtcaccgtccgctcggcctcggcccg	CRISPR spacer
cttctcggacaccatccgctcggcctccaccat	Protospacer
* .***** ****.************* .**

138. spacer 36.1|5688372|34|NZ_CP016824|CRISPRCasFinder matches to NC_010335 (Caulobacter sp. K31 plasmid pCAUL01, complete sequence) position: , mismatch: 8, identity: 0.765

ggatcgatcccgccgccccgcgccccgccgatgc--	CRISPR spacer
ggatcgatccggccg--ccgcgcgccgccagcacct	Protospacer
********** ****  ****** *****....*

139. spacer 38.1|7051446|32|NZ_CP016824|CRISPRCasFinder matches to NZ_LR134465 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence) position: , mismatch: 8, identity: 0.75

tggtgtgcgcggaggccgcgggccgggtgcgg	CRISPR spacer
tgccgtgcgcggcggccgcgagccgggtcgcc	Protospacer
** .******** *******.*******

140. spacer 38.1|7051446|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP029359 (Azospirillum sp. CFH 70021 plasmid unnamed4) position: , mismatch: 8, identity: 0.75

tggtgtgcgcggaggccgcgggccgggtgcgg	CRISPR spacer
gcgggtgcgcggcggccgggggccgggaaccg	Protospacer
  * ******** ***** ******** .* *

141. spacer 4.2|1604612|30|NZ_CP016824|CRISPRCasFinder matches to NZ_CP017076 (Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence) position: , mismatch: 9, identity: 0.7

aaccagcccggccggcgcttgaggccaaac	CRISPR spacer
gctcgacccggtcggcgcttgaggccatga	Protospacer
. .*..*****.*************** .

142. spacer 7.2|2167041|32|NZ_CP016824|CRISPRCasFinder matches to MT114163 (Mycobacterium phage Settecandela, complete genome) position: , mismatch: 9, identity: 0.719

cgctggctgctcgacccgcaggcgacggcgaa	CRISPR spacer
catctgctgctcgaccggcaggcgacggttct	Protospacer
*... *********** ***********.

143. spacer 7.2|2167041|32|NZ_CP016824|CRISPRCasFinder matches to MK937592 (Mycobacterium phage Phrappuccino, complete genome) position: , mismatch: 9, identity: 0.719

cgctggctgctcgacccgcaggcgacggcgaa	CRISPR spacer
catctgctgctcgaccggcaggcgacggttct	Protospacer
*... *********** ***********.

144. spacer 7.2|2167041|32|NZ_CP016824|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 9, identity: 0.719

cgctggctgctcgacccgcaggcgacggcgaa	CRISPR spacer
caggtactgctcgacgcgcaggcgacgccgct	Protospacer
*.   .********* *********** **

145. spacer 7.2|2167041|32|NZ_CP016824|CRISPRCasFinder matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 9, identity: 0.719

cgctggctgctcgacccgcaggcgacggcgaa	CRISPR spacer
tcacggctgatcgaccagcaggcgacgctgat	Protospacer
.  .***** ****** ********** .**

146. spacer 7.2|2167041|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 9, identity: 0.719

cgctggctgctcgacccgcaggcgacggcgaa	CRISPR spacer
tcacggctgatcgaccagcaggcgacgctgat	Protospacer
.  .***** ****** ********** .**

147. spacer 7.2|2167041|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP016288 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed7, complete sequence) position: , mismatch: 9, identity: 0.719

cgctggctgctcgacccgcaggcgacggcgaa	CRISPR spacer
ggctggcagctcgaaccgcaggcgcagatcat	Protospacer
 ****** ****** *********  *.. *

148. spacer 7.2|2167041|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP054617 (Azospirillum oryzae strain KACC 14407 plasmid unnamed3, complete sequence) position: , mismatch: 9, identity: 0.719

cgctggctgctcgacccgcaggcgacggcgaa	CRISPR spacer
gaccggctgctcgacgcgctggcgacgctgcc	Protospacer
 .*.*********** *** ******* .*

149. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NC_016585 (Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence) position: , mismatch: 9, identity: 0.7

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
aggtcgcggcgccatgggcatcggccagtc	Protospacer
  * *****.***************   ..

150. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to CP000876 (Herpetosiphon aurantiacus DSM 785 plasmid pHAU01, complete sequence) position: , mismatch: 9, identity: 0.7

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
gcggtgcggtggcatgggcatcggtcaggc	Protospacer
 ***.****** ************.    .

151. spacer 20.4|3778733|30|NZ_CP016824|CRT matches to NC_015741 (Roseobacter litoralis Och 149 plasmid pRLO149_94, complete sequence) position: , mismatch: 9, identity: 0.7

ccggcgcggtgccatgggcatcggcgtcct	CRISPR spacer
tgcgcgcgttgccatgcgcatcggcgcagc	Protospacer
.  ***** ******* *********.  .

152. spacer 20.5|3778549|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP050092 (Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence) position: , mismatch: 9, identity: 0.719

cgagcaggacccggtgcgcccggtcggagagc	CRISPR spacer
gggggccaacccggtccgcccggtcggataga	Protospacer
 *.*   .******* ************ **

153. spacer 20.5|3778549|32|NZ_CP016824|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 9, identity: 0.719

cgagcaggacccggtgcgcccggtcggagagc	CRISPR spacer
gtggcaggacccggtgcccgcggtcgaccacc	Protospacer
  .************** * ******.  * *

154. spacer 20.5|3778549|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP021355 (Rhodococcus sp. S2-17 plasmid pRB98, complete sequence) position: , mismatch: 9, identity: 0.719

cgagcaggacccggtgcgcccggtcggagagc	CRISPR spacer
taaggagtacccggtgcgcccggtcccggccc	Protospacer
..** ** *****************  .*  *

155. spacer 20.6|3778610|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP050092 (Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence) position: , mismatch: 9, identity: 0.719

cgagcaggacccggtgcgcccggtcggagagc	CRISPR spacer
gggggccaacccggtccgcccggtcggataga	Protospacer
 *.*   .******* ************ **

156. spacer 20.6|3778610|32|NZ_CP016824|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 9, identity: 0.719

cgagcaggacccggtgcgcccggtcggagagc	CRISPR spacer
gtggcaggacccggtgcccgcggtcgaccacc	Protospacer
  .************** * ******.  * *

157. spacer 20.6|3778610|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP021355 (Rhodococcus sp. S2-17 plasmid pRB98, complete sequence) position: , mismatch: 9, identity: 0.719

cgagcaggacccggtgcgcccggtcggagagc	CRISPR spacer
taaggagtacccggtgcgcccggtcccggccc	Protospacer
..** ** *****************  .*  *

158. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP045120 (Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
tcgtcggccgcgccgccctcaccggccaggag	Protospacer
. ***.********* ********** . *

159. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP016820 (Rhodococcus sp. p52 plasmid pDF02, complete sequence) position: , mismatch: 9, identity: 0.719

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
atctcagccgcgcagacctgaccggcacggac	Protospacer
   ********** ***** *******  * .

160. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP017941 (Phyllobacterium zundukense strain Tri-48 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
aaatcgcgcgcgccgacctcaccgaaagcgcc	Protospacer
 ..**.  ****************. *****.

161. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP015268 (Mycobacterium chimaera strain ZUERICH-2 plasmid unnamed 1, complete sequence) position: , mismatch: 9, identity: 0.719

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
agggtgcgcgcgccgacctcatcgacagcgcc	Protospacer
 ** ..  *************.**.******.

162. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 9, identity: 0.719

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
agcccgaccgctccgaccccaccggcagcggc	Protospacer
 * .*..**** ******.*********** .

163. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP015279 (Mycobacterium chimaera strain DSM 44623 plasmid unnamed 1, complete sequence) position: , mismatch: 9, identity: 0.719

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
agggtgcgcgcgccgacctcatcgacagcgcc	Protospacer
 ** ..  *************.**.******.

164. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP024310 (Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence) position: , mismatch: 9, identity: 0.719

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
atctctaccgcgccgaccgcaccggccgcgag	Protospacer
   ** .*********** ******* ***

165. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.719

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
agcccgaccgctccgaccccaccggcagcggc	Protospacer
 * .*..**** ******.*********** .

166. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP023064 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence) position: , mismatch: 9, identity: 0.719

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
atctctaccgcgccgaccgcaccggccgcgag	Protospacer
   ** .*********** ******* ***

167. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.719

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
agcccgaccgctccgaccccaccggcagcggc	Protospacer
 * .*..**** ******.*********** .

168. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 9, identity: 0.719

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
agcccgaccgctccgaccccaccggcagcggc	Protospacer
 * .*..**** ******.*********** .

169. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NC_008242 (Chelativorans sp. BNC1 plasmid 1, complete sequence) position: , mismatch: 9, identity: 0.719

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
cgcggcgcggcgccatcggcatcggccgttcc	Protospacer
. ********.***** *********  ...*

170. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to MK737942 (Microbacterium phage Sucha, complete genome) position: , mismatch: 9, identity: 0.719

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
tcctccgcggtgccatgggcatcgagggggag	Protospacer
***  *******************. *

171. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to CP000876 (Herpetosiphon aurantiacus DSM 785 plasmid pHAU01, complete sequence) position: , mismatch: 9, identity: 0.719

tccggcgcggtgccatgggcatcggcgtcctc-----	CRISPR spacer
agcggtgcggtggcatgggcatcgg-----tcaggcg	Protospacer
  ***.****** ************     **

172. spacer 21.1|3967952|31|NZ_CP016824|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 9, identity: 0.71

ctttggcctcaagcgccggccgggctggttt	CRISPR spacer
atatggcctcattcgccggccgggcttcggc	Protospacer
 * ********  *************    .

173. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NC_017588 (Thermus thermophilus JL-18 plasmid pTTJL1801, complete sequence) position: , mismatch: 9, identity: 0.727

cgcctcggtcaccgtccgctcggcctcggcccg	CRISPR spacer
cgcctcggtcaccgtgcgcccggcggtggagaa	Protospacer
*************** ***.****  .**   .

174. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NZ_LR027520 (Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence) position: , mismatch: 9, identity: 0.727

cgcctcggtcaccgtccgctcggcctcggcccg	CRISPR spacer
cgcctcggtcaccgtgcgcccggcggtggagaa	Protospacer
*************** ***.****  .**   .

175. spacer 32.6|5179626|33|NZ_CP016824|CRISPRCasFinder matches to NZ_LR134455 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 13, complete sequence) position: , mismatch: 9, identity: 0.727

ggaacgcgcccccagcgactcggcctccgtggc	CRISPR spacer
catacgctcccccaccgactcggcctcgtccgc	Protospacer
 . **** ****** ************  . **

176. spacer 36.1|5688372|34|NZ_CP016824|CRISPRCasFinder matches to NZ_CP025805 (Sulfitobacter sp. SK012 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

ggatcgatcccgccgccccgcgccccgccgatgc	CRISPR spacer
ggatcgatcctgcagccccgcgcccaaaccttca	Protospacer
**********.** *********** . *  *

177. spacer 36.1|5688372|34|NZ_CP016824|CRISPRCasFinder matches to NZ_CP025806 (Sulfitobacter sp. SK012 plasmid unnamed3, complete sequence) position: , mismatch: 9, identity: 0.735

ggatcgatcccgccgccccgcgccccgccgatgc	CRISPR spacer
ggatcgatcctgcagccccgcgcccaaaccttca	Protospacer
**********.** *********** . *  *

178. spacer 36.1|5688372|34|NZ_CP016824|CRISPRCasFinder matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 9, identity: 0.735

ggatcgatcccgccgccccgcgccccg-ccgatgc	CRISPR spacer
caccggatcccgccgcccgccgccccgcccgacg-	Protospacer
 . . *************  ******* ****.*

179. spacer 36.1|5688372|34|NZ_CP016824|CRISPRCasFinder matches to NZ_CP031753 (Rhodobacter sphaeroides strain EBL0706 plasmid p.B, complete sequence) position: , mismatch: 9, identity: 0.735

ggatcgatcccgccgccccgcgccccgccgatgc	CRISPR spacer
gcatgaccgccgctgccccgcgccccgtcgatgt	Protospacer
* ** . . ****.*************.*****.

180. spacer 38.1|7051446|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 9, identity: 0.719

tggtgtgcgcggaggccgcgggccgggtgcgg	CRISPR spacer
cccttcgcccggaggccgcggaccgggtgccc	Protospacer
.  * .** ************.********

181. spacer 38.1|7051446|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP027299 (Streptomyces sp. SGAir0924 plasmid unnamed_5) position: , mismatch: 9, identity: 0.719

tggtgt----gcgcggaggccgcgggccgggtgcgg	CRISPR spacer
----gccacggcgcggaggcggccggccgggtgtcg	Protospacer
    *.    ********** ** *********. *

182. spacer 7.1|2166980|32|NZ_CP016824|CRISPRCasFinder matches to NC_007336 (Cupriavidus pinatubonensis JMP134 megaplasmid, complete sequence) position: , mismatch: 10, identity: 0.688

aaccccatcaagctgagcgacgtcgacccgac	CRISPR spacer
ggtgccatcaagctgatcgacggcgactttgc	Protospacer
... ************ ***** ****.. .*

183. spacer 7.1|2166980|32|NZ_CP016824|CRISPRCasFinder matches to MT708548 (Streptomyces phage Salutena, complete genome) position: , mismatch: 10, identity: 0.688

aaccccatcaagctgagcgacgtcgacccgac	CRISPR spacer
tcgttcgcgaagccgagcgacttcgacccgac	Protospacer
   ..*.. ****.******* **********

184. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NC_019848 (Sinorhizobium meliloti GR4 plasmid pRmeGR4c, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

185. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NC_003037 (Sinorhizobium meliloti 1021 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

186. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP019585 (Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatagc	Protospacer
 ****** *************.** * ... .

187. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NC_017327 (Sinorhizobium meliloti SM11 plasmid pSmeSM11c, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

188. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP021798 (Sinorhizobium meliloti strain USDA1106 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

189. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NC_017324 (Sinorhizobium meliloti BL225C plasmid pSINMEB01, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

190. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP009145 (Sinorhizobium meliloti strain RMO17 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

191. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP021827 (Sinorhizobium meliloti strain KH35c plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

192. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP021801 (Sinorhizobium meliloti strain USDA1021 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

193. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP021830 (Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

194. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP021824 (Sinorhizobium meliloti strain KH46 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

195. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NC_018683 (Sinorhizobium meliloti Rm41 plasmid pSYMA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

196. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP021794 (Sinorhizobium meliloti strain USDA1157 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

197. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP021809 (Sinorhizobium meliloti strain Rm41 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

198. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP021805 (Sinorhizobium meliloti strain T073 plasmid psymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

199. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP021217 (Sinorhizobium meliloti RU11/001 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

200. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP019483 (Sinorhizobium meliloti strain B401 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

201. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP019486 (Sinorhizobium meliloti strain B399 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

202. spacer 20.7|3778671|32|NZ_CP016824|CRISPRCasFinder matches to NC_020527 (Sinorhizobium meliloti 2011 plasmid pSymA, complete sequence) position: , mismatch: 10, identity: 0.688

cggtcagccgcgccgacctcaccggcagcgct	CRISPR spacer
gggtcagacgcgccgacctcatcgtccatcgc	Protospacer
 ****** *************.** * ..  .

203. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NC_004719 (Streptomyces avermitilis MA-4680 = NBRC 14893 plasmid SAP1, complete sequence) position: , mismatch: 10, identity: 0.688

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
ccgtgcgcggtgcccagggcatcggcgatgca	Protospacer
.*  **********  *********** . .

204. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP017105 (Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence) position: , mismatch: 10, identity: 0.688

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
gctggctcggtgccatggccatcggcccggaa	Protospacer
 *.*** *********** ******* .

205. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP017244 (Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence) position: , mismatch: 10, identity: 0.688

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
gctggctcggtgccatggccatcggcccggat	Protospacer
 *.*** *********** ******* .   .

206. spacer 20.8|3778732|32|NZ_CP016824|CRISPRCasFinder matches to NC_015741 (Roseobacter litoralis Och 149 plasmid pRLO149_94, complete sequence) position: , mismatch: 10, identity: 0.688

tccggcgcggtgccatgggcatcggcgtcctc	CRISPR spacer
atgcgcgcgttgccatgcgcatcggcgcagcc	Protospacer
 .  ***** ******* *********.  .*

207. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 10, identity: 0.697

cgcctcggtcaccgtccgctcggcctcggcccg	CRISPR spacer
cgcctcggtcaccgtccgccccgcggtcacgaa	Protospacer
*******************.* **  . .*  .

208. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NZ_AP019802 (Thermus thermophilus strain HC11 plasmid pHC11, complete sequence) position: , mismatch: 10, identity: 0.697

cgcctcggtcaccgtccgctcggcctcggcccg	CRISPR spacer
cgcctcggtcaccgtccgccccgcggtcacgaa	Protospacer
*******************.* **  . .*  .

209. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to MN234201 (Mycobacterium phage Guanica15, complete genome) position: , mismatch: 10, identity: 0.697

cgcctcggtcaccgtccgctcggcctcggcccg	CRISPR spacer
agcctcggtcgccgcccgctcggccgctttatc	Protospacer
 *********.***.********** *  . .

210. spacer 36.1|5688372|34|NZ_CP016824|CRISPRCasFinder matches to NZ_LR134451 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 9, complete sequence) position: , mismatch: 10, identity: 0.706

ggatcgatcccgccgccccgcgccccgccgatgc	CRISPR spacer
ccggcgatcccgccgccctgcgcaccgcgctcgc	Protospacer
  . **************.**** ****   .**

211. spacer 36.1|5688372|34|NZ_CP016824|CRISPRCasFinder matches to NZ_CP040824 (Paraoceanicella profunda strain D4M1 plasmid pD4M1F, complete sequence) position: , mismatch: 10, identity: 0.706

ggatcgatcccgccgccccgcgccccgccgatgc	CRISPR spacer
ccccaggccacgccgcccggcgcgccgccgatgc	Protospacer
   . *..* ******** **** **********

212. spacer 36.1|5688372|34|NZ_CP016824|CRISPRCasFinder matches to NZ_CP035513 (Haematobacter massiliensis strain OT1 plasmid pOT1-3, complete sequence) position: , mismatch: 10, identity: 0.706

ggatcgatcccgccgccccgcgccccgccgatgc	CRISPR spacer
gcgatggagccgacgccccccgccccgccgatga	Protospacer
* . .*.  *** ****** *************

213. spacer 36.1|5688372|34|NZ_CP016824|CRISPRCasFinder matches to NZ_CP039965 (Pseudorhodobacter sp. S12M18 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.706

ggatcgatcccgccgccccgcgccccgccgatgc	CRISPR spacer
ggatcaatcccgacgccccgcgccaccttcaaaa	Protospacer
*****.****** *********** * .. * .

214. spacer 38.1|7051446|32|NZ_CP016824|CRISPRCasFinder matches to NZ_CP040820 (Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence) position: , mismatch: 10, identity: 0.688

tggtgtgcgcggaggccgcgggccgggtgcgg	CRISPR spacer
ccttcccggcggaggcggcgggccgcgtgcgc	Protospacer
.  * .  ******** ******** *****

215. spacer 7.2|2167041|32|NZ_CP016824|CRISPRCasFinder matches to NC_010625 (Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence) position: , mismatch: 11, identity: 0.656

cgctggctgctcgacccgcaggcgacggcgaa	CRISPR spacer
tctcaaatgctcgacgcgcaggccacggcggc	Protospacer
. .... ******** ******* ******.

216. spacer 32.4|5179485|42|NZ_CP016824|CRISPRCasFinder matches to NZ_CP030864 (Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence) position: , mismatch: 11, identity: 0.738

ggcccgcgcggcccgctcctcggcctccgccacggcgcgcgc	CRISPR spacer
cagcgtcgcggcgcgctcctcggccaccgccacggccgccgg	Protospacer
 . *  ****** ************ **********   **

217. spacer 32.5|5179560|33|NZ_CP016824|CRISPRCasFinder matches to NZ_CP054616 (Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence) position: , mismatch: 11, identity: 0.667

cgcctcggtcaccgtccgctcggcctcggcccg	CRISPR spacer
gatgcaggtcaccgtccgctcggccatggcgat	Protospacer
 .. . ******************* .***

218. spacer 22.1|4021017|40|NZ_CP016824|PILER-CR matches to KU530220 (Streptomyces phage Xkcd426, complete genome) position: , mismatch: 12, identity: 0.7

gcagtgaccggcgcggtggggccgagcgtcaccacacttc	CRISPR spacer
atcgtgaccggcgcggtgggggccagcgtcacgtcctgcg	Protospacer
.. ****************** * ********  * . .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP016824

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CRISPR-Cas detection and classification

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