CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP012334	Bordetella sp. H567 chromosome, complete genome	11 crisprs	DEDDh,DinG,RT,cas3,csa3,WYL	0	3	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012334_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012334_1

40832-40958

Orphan

Consensus_repeat	Method
CCGCCGGGCCGCCCCAAGGCAAAAAGCCCCCTTGGGGGGCAGCAAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012334_1

>merge|NZ_CP012334|1|40832-40958|CRISPRCasFinder
CCGCCGGGCCGCCCCAAGGCAAAAAGCCCCCTTGGGGGGCAGCAAGCCGATTTATCGGCGCGGCGTGGGGGTTCTTCTTTCCGCCGGGCCGCCCCAAGGCAAAAAGCCCCCTTGCGGGGCAGCAAGC

>NZ_CP012334|1|1|40832-40958|CRISPRCasFinder
CCGCCGGGCCGCCCCAAGGCAAAAAGCCCCCTTGGGGGGCAGCAAGC	CGATTTATCGGCGCGGCGTGGGGGTTCTTCTTT
CCGCCGGGCCGCCCCAAGGCAAAAAGCCCCCTTGCGGGGCAGCAAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012334.1\|WP_066631303.1\|31780_32800_-\|asparaginase	unknown	unknown	gnl\|CDD\|199208
NZ_CP012334.1\|WP_066631312.1\|38305_39088_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213186
NZ_CP012334.1\|WP_066631306.1\|33858_35151_+\|amidase	unknown	unknown	gnl\|CDD\|223232
NZ_CP012334.1\|WP_066631328.1\|47435_48296_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NZ_CP012334.1\|WP_066631321.1\|43914_44220_-\|DUF4148-domain-containing-protein	unknown	unknown	gnl\|CDD\|379321
NZ_CP012334.1\|WP_066631320.1\|43195_43501_-\|DUF4148-domain-containing-protein	unknown	unknown	unknown
NZ_CP012334.1\|WP_066631325.1\|46087_46393_-\|DUF4148-domain-containing-protein	unknown	unknown	gnl\|CDD\|379321
NZ_CP012334.1\|WP_066631308.1\|35193_36372_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380559
NZ_CP012334.1\|WP_066631310.1\|36430_37300_+\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119324
NZ_CP012334.1\|WP_066631331.1\|48297_49146_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213021
NZ_CP012334.1\|WP_083228547.1\|46675_47353_-\|FCD-domain-containing-protein	unknown	unknown	gnl\|CDD\|183181
NZ_CP012334.1\|WP_083228541.1\|30823_31741_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176106
NZ_CP012334.1\|WP_066631311.1\|37307_38309_+\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119323
NZ_CP012334.1\|WP_066631273.1\|44642_44948_-\|DUF4148-domain-containing-protein	unknown	unknown	gnl\|CDD\|379321
NZ_CP012334.1\|WP_066631315.1\|40976_41969_-\|XdhC-family-protein	unknown	unknown	gnl\|CDD\|224886
NZ_CP012334.1\|WP_066631319.1\|42465_42771_-\|DUF4148-domain-containing-protein	unknown	unknown	unknown
NZ_CP012334.1\|WP_066631304.1\|32832_33720_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182183
NZ_CP012334.1\|WP_066631313.1\|39065_39776_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223487
NZ_CP012334.1\|WP_066631314.1\|39869_40769_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|200601
NZ_CP012334.1\|WP_066631322.1\|45368_45674_-\|DUF4148-domain-containing-protein	unknown	unknown	gnl\|CDD\|379321

Protein	Function_ID	Function_description	E-value
NZ_CP012334.1\|WP_066631303.1\|31780_32800_-\|asparaginase	gnl\|CDD\|199208	cd08964, L-asparaginase_II, Type II (periplasmic) bacterial L-asparaginase. Asparaginases (amidohydrolases, E.C. 3.5.1.1) are enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases. This model represents type II L-asparaginases, which tend to be highly specific for asparagine and localized to the periplasm. They are potent antileukemic agents and have been used in the treatment of acute lymphoblastic leukemia (ALL), but not without severe side effects. Tumor cells appear to have a heightened dependence on exogenous L-aspartate, and depleting their surroundings of L-aspartate may starve cancerous ALL cells. Type II L-asparaginase acts as a tetramer, which is actually a dimer of two tightly bound dimers. A conserved threonine residue is thought to supply the nucleophile hydroxy-group that attacks the amide bond. Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of them are annotated as asparaginase/glutaminase.	1.87531e-120
NZ_CP012334.1\|WP_066631312.1\|38305_39088_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	2.1577e-100
NZ_CP012334.1\|WP_066631306.1\|33858_35151_+\|amidase	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	1.34543e-80
NZ_CP012334.1\|WP_066631328.1\|47435_48296_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.1395e-85
NZ_CP012334.1\|WP_066631321.1\|43914_44220_-\|DUF4148-domain-containing-protein	gnl\|CDD\|379321	pfam13663, DUF4148, Domain of unknown function (DUF4148).	0.00572248
NZ_CP012334.1\|WP_083228547.1\|46675_47353_-\|FCD-domain-containing-protein	gnl\|CDD\|183181	PRK11534, PRK11534, DNA-binding transcriptional regulator CsiR; Provisional.	7.65511e-35
NZ_CP012334.1\|WP_066631325.1\|46087_46393_-\|DUF4148-domain-containing-protein	gnl\|CDD\|379321	pfam13663, DUF4148, Domain of unknown function (DUF4148).	0.00173473
NZ_CP012334.1\|WP_066631308.1\|35193_36372_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380559	cd06336, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.	1.31698e-123
NZ_CP012334.1\|WP_066631310.1\|36430_37300_+\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	2.98172e-66
NZ_CP012334.1\|WP_066631331.1\|48297_49146_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213021	cd10916, CE4_PuuE_HpPgdA_like, Catalytic domain of bacterial PuuE allantoinases, Helicobacter pylori peptidoglycan deacetylase (HpPgdA), and similar proteins. This family is a member of the very large and functionally diverse carbohydrate esterase 4 (CE4) superfamily. It contains bacterial PuuE (purine utilization E) allantoinases, a peptidoglycan deacetylase from Helicobacter pylori (HpPgdA), Escherichia coli ArnD, and many uncharacterized homologs from all three kingdoms of life. PuuE allantoinase appears to be metal-independent and specifically catalyzes the hydrolysis of (S)-allantoin into allantoic acid. Different from PuuE allantoinase, HpPgdA has the ability to bind a metal ion at the active site and is responsible for a peptidoglycan modification that counteracts the host immune response. Both PuuE allantoinase and HpPgdA function as a homotetramer. The monomer is composed of a 7-stranded barrel with detectable sequence similarity to the 6-stranded barrel NodB homology domain of polysaccharide deacetylase (DCA)-like proteins in the CE4 superfamily, which removes N-linked or O-linked acetyl groups from cell wall polysaccharides. However, in contrast with the typical DCAs, PuuE allantoinase and HpPgdA might not exhibit a solvent-accessible polysaccharide binding groove and only recognize a small substrate molecule. ArnD catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol.	6.49978e-63
NZ_CP012334.1\|WP_083228541.1\|30823_31741_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	3.91735e-52
NZ_CP012334.1\|WP_066631311.1\|37307_38309_+\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119323	cd06581, TM_PBP1_LivM_like, Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	4.71149e-65
NZ_CP012334.1\|WP_066631273.1\|44642_44948_-\|DUF4148-domain-containing-protein	gnl\|CDD\|379321	pfam13663, DUF4148, Domain of unknown function (DUF4148).	0.00582045
NZ_CP012334.1\|WP_066631315.1\|40976_41969_-\|XdhC-family-protein	gnl\|CDD\|224886	COG1975, XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones].	3.50405e-63
NZ_CP012334.1\|WP_066631304.1\|32832_33720_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|182183	PRK09986, PRK09986, LysR family transcriptional regulator.	5.76443e-60
NZ_CP012334.1\|WP_066631313.1\|39065_39776_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	1.39321e-105
NZ_CP012334.1\|WP_066631314.1\|39869_40769_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|200601	cd10979, CE4_PuuE_like, Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases. The family includes a group of uncharacterized prokaryotic polysaccharide deacetylases (DCAs) that show high sequence similarity to the catalytic domain of bacterial PuuE (purine utilization E) allantoinases. PuuE allantoinase specifically catalyzes the hydrolysis of (S)-allantoin into allantoic acid. It functions as a homotetramer. Its monomer is composed of a 7-stranded barrel with detectable sequence similarity to the 6-stranded barrel NodB homology domain of DCA-like proteins in the CE4 superfamily, which removes N-linked or O-linked acetyl groups from cell wall polysaccharides. PuuE allantoinase appears to be metal-independent and acts on a small substrate molecule, which is distinct from the common feature of DCAs which are normally metal ion dependent and recognize multimeric substrates.	1.14152e-122
NZ_CP012334.1\|WP_066631322.1\|45368_45674_-\|DUF4148-domain-containing-protein	gnl\|CDD\|379321	pfam13663, DUF4148, Domain of unknown function (DUF4148).	0.00203579

>NZ_CP012334.1|WP_066631314.1|39869_40769_+|polysaccharide-deacetylase-family-protein
MLLPYHDRYPYSAITRRPDYSWPEGKRLAVYLGLNIEHFAFGTGKGHHLGTELPQPDARGFAWRDYGNRVGVWRLLELFDELGLPASHLMNTVLFEYCPEVLEPILKRGDEIIGHGRTNAEAQGHLWAADEARLLTEVREAIKKHTGQDVRGWMGPWMSQSAQTPELLVDTGYKFVMDWPADDQPVWMKTGSGPLMSVPYPLEINDSPQMLVRRHTAQDFEQMIIEQFEEMLQQSEKQPLVCGIALHTMIVGQPYRLRALRRALKYIVEHPQRDKVWFTRPGAIYDHCAGLKDGVMVRP
>NZ_CP012334.1|WP_066631313.1|39065_39776_+|ABC-transporter-ATP-binding-protein
MSLLELRNLDVRYGRVAGTRSLSLSIGEAETVALIGSNGAGKSSTLKAITGLVNGYGGDVLWQGKSIKGMAASEVVKLGIGFSPEGRRVFPSLTVQENLKMGAFGRGGDRLAERMEQMFGYFPRLKERARQAAGSLSGGEQQMLAIGRALMSGPKLFLLDEPSLGLAPIIVERIGDILLEIQQREGLAFVLAEQNANWAMRVARRTAILQLGEKVFDDASAALLEDPKVQTAFLGV
>NZ_CP012334.1|WP_066631312.1|38305_39088_+|ABC-transporter-ATP-binding-protein
MKKLLNVEAIGRSFGGLKAVDGVSFEVYEGEILGVIGPNGAGKTTLVNLISGVIKPSRGAVAFRDETVTGMAPSRLTERGLVRTFQSTAVYGARSVRENIVRGAYLTRYPGFLSTLLDTPRARRRRAESDAQVDELLDRMGLRAVADAAAGSLPYGLQKILGIAIALAARPTLLMLDEPVAGLSAEETDQVRDAILCVRDSGVTVMVVDHNMRFIAGLCDRLLVVAAGQELTRGKPDEVLRDPRVVEAYLGTRNVTAGIA
>NZ_CP012334.1|WP_066631311.1|37307_38309_+|branched-chain-amino-acid-ABC-transporter-permease
MSNISSNTLAARRPRTGVTRGMTVLCVGILATVILAVLPHVADNPFILAIGALILLNVIGALSLHLIIRTGHISLSHAGFMGVGAYACALSVLKLGVSPFVGLAIGAAASGLLALLVGPILLRLTGKYFVLVTFLLGEIIRLVLVEWESLTGGSNGLSNLPDLHAGWNSPLAQYYIALVAAVLVAALCIRLLMSETGRAIDAVREAQRLTECAGVPVLRLKVGVFVLGCALVGLQGGLLAFFMHYIDPTTFGMTDSLNLVVMNVLGGMYHVVGPIIGAVFLVALPELLRGYVEVQRILFGVALIVVMASFPTGMAGLAAMLRGMRRERKEARA
>NZ_CP012334.1|WP_066631310.1|36430_37300_+|branched-chain-amino-acid-ABC-transporter-permease
MFSAPVLTQVLINGLSLSAIYVLIALGFTLLFGIMKVVNFAHGSFAMLGGYALHYYFGEFKLPYVVAILLAGLTVAAASMVLEWLVFRRFYQKMFQSMIGLLGLDIAIVYSSVLVWDVYERSIPAAVDAMVPIGAVSIPADKLMIIGIAIVVLLAFWAFMSLSRYGLAVRAASEDIEIAEAQGVNTRRIYQLAFFLAVFMTAIAGAIYAQTYALSPFMGDRPLMVAFIVVILGGMGSIPGAALGGVLFGFGESFLSTFYGSATSTFVSFGVVIALLVVRPWGLLGKPER
>NZ_CP012334.1|WP_066631308.1|35193_36372_+|ABC-transporter-substrate-binding-protein
MHAKKLLGSLILTALGAGVALSAQAQETLKIGGIGPLSGGGTAWGLAVQRGVQMAIDEANAQGGLKIGGKTYKPELVMYDDKYTATGGRTAAERLVNYDKVNFIIGPIGTPSAMAVVPITNQAKAIVLSDGYAPDILKQGGQNGYNFRSMNSNVEFGPAMVKWLKDTHPKVKKVALIVPNDATGQVVMPTLGQTYKDNGYTVWSESYERGSKEFTPLLTRMMAQGVDLLDLNLNAPGEAGLLVKQARQIGYKGLIWQVGGPGIDEINDIAGPNAEGFMSYDVFDFREPGAQKFVDAYKKRWSGVINAQTPGWYNSARILFKALENAGTVTDTDKVRTALENLGGYDAGIYGPVVWGGQKAYGVNRQLLNKFWITQIKDGKPQTITTLTPVKE
>NZ_CP012334.1|WP_066631306.1|33858_35151_+|amidase
MKPLNQLTAWEAAAAIERGETTPTAVVQACLDRIAERNDQIRAFVACDPQRALAGAKQAEAMAAGPLRGVPFAAKDIFDTADYPTEYGSPIYRGHRPVTDAGCVAMAKHRGAVLIGKVATGEFATQTPSKAVNPLRVTHTPGGSSSGSGAAVGDCMVQVAFGTQTTGSIVRPAIYCGAVGYKPSFGLIATAGMKALSPSQDTIGVITRDVADAAFFTMGLHGARDVMSGSILRPRIGLCLSRQWDYAHPSTIAAIERAADRLQKAGAQVTRFWLPAELEALEATQLRVFAFEARQTLAQERLNSESLLSPRLQARLQSGAEIGLDEYTGMLQHVAQMRARARALFDDYDVLLYPAADGEAEAGHDYAGSPRYGAIWTLLHMPCVSFPLEIGPGGLPLGAQLIGAYGQDTRLLAAARFATSVLGPVPRPTA
>NZ_CP012334.1|WP_066631304.1|32832_33720_-|LysR-family-transcriptional-regulator
MPLLSRALRAFVVVAEELHFGRAAIRLNISQPPLSQLIRQFEAEVGTELFVRSTRSVRLTQAGVVLLHRARRLIDDNDSTLRAVRRAGSGDAGRLAVGFVSTAAYRVLPGAIARYRAAYPDVELVLFEELTGVITDRLMSGTIDIAIFRRLPRAIEHDLIFERVHREKMVLAMPADHPYRDLDQVPMARLDGQAMVGFQREGSSYFNAVQTRLFRDHNVRPRIVYESVLPTLLALVEGGMGMALVPESAAGLRNSVVYRPLSGLPNAFDVDLYCARRPDNLNPTAQAFARILQQG
>NZ_CP012334.1|WP_066631303.1|31780_32800_-|asparaginase
MTDSTSLPRVAIIGCGGTITSRGTGPLDTMDYPEFGAKLSVEDVLRAIPETASVARAVLVPFREVSSSAITMQDWFALRTTIRRMAAEQPDLAGFVILHGTATLEETAFFLDLTLSLEQPVVLVGAQRPLSAVGSDAPMNVIAALRTAAAPQSRGRGVLVVLNDEISSARDVVKTHTLRVQTFRSADFGPLGVVDPDGVFYYRRNEAREVDPTLPAFTAVPDDAVLPRVDILYSYIGADGTLVQACVAAGARGIVCAGLAPGMPAKAERDAYERARRDGVALVQCTRAASGRVANRRALRENGWIAGNSLSPQKARILLALALSQTSDLEVLRALFGRY
>NZ_CP012334.1|WP_083228541.1|30823_31741_+|LysR-family-transcriptional-regulator
MSIRASNLDLRMVQQFLAVAETLSFRKAAEQMHMAQPPLSQAIMRLEALVQARLFERSPRGVRLTPAGEVFKLEAVRLLNQASRALERTQRAGRGELGTVHVGFIGPAMIGLLPKVILAFRERFAGVELALHEGSSMQVAGMIHSDTVDIGFLVTPAELQPDVSTEVIVVDTLVAALPAGHRLSGEPRIRLEELADDAFVLFSAQGVPTLSSRIAVLCRQAGFEARIAQEAVQISTVLGLVAGGLGVSVLPGSIVALATGAVVCKPIVADAELLRVKICAAYRRDRLSDAAQAFLMTARLHANGG
>NZ_CP012334.1|WP_066631315.1|40976_41969_-|XdhC-family-protein
MNSLDIDVLQHARDWVAEGHRVHLITVVQTWGSAPRQAGALAALRGDGRLVGSVSGGCVEDDLIARAVAGTLPDMADRVTYGITSEEAARFGLPCGGTLRLVVEPLHDTLWLDPVLQDVRAHRLIMRTVDLQTGTWTLAPASPIDGPDFDGRTFRSVYGPHWRLLIIGANQTARVLSEIATALDFHVMVCDPREEFFADWNMPNVTLLTSMPDDTVTDIGTDERTAIVAVTHDPKLDDMALLEALKSPAFYVGALGSAPNQAKRRERLRMFDLSDEEIGRLHGPVGLRIASRTPAEIAVAIAAELVWVRNTLGGAAACTPNPSTASREGS
>NZ_CP012334.1|WP_066631319.1|42465_42771_-|DUF4148-domain-containing-protein
MKAKTIVSALILSFAAIGAAQAANSEPNNVPFQGVYGQAASNVNRTYVLDQLLQARSAGLTGNADIDNTPFTAQADSGVSHAQIARGSDFGDSNNQPFQGA
>NZ_CP012334.1|WP_066631320.1|43195_43501_-|DUF4148-domain-containing-protein
MKAKTIVSALILSFAAIGAAQAANSEPNTVPFQGVYGQAVDSVSRTQVLGELHQARTAGLTGNADIDNTPFTAQADSGVSHAQIARGSDFGDSNNQPFQGA
>NZ_CP012334.1|WP_066631321.1|43914_44220_-|DUF4148-domain-containing-protein
MKAKTIVSALILSFAAIGAAQAANSEPNTVPFQGVYGQAVDSVSRTQVLGELQQARTAGLTGNADIDNAPYTAQADSGISHAQIARGSDFGDSNNQPFQGA
>NZ_CP012334.1|WP_066631273.1|44642_44948_-|DUF4148-domain-containing-protein
MKAKTIVSALILSFAAIGAAQAANSEPNNVPFQGVYGQAANSVSRTQVLGELQQARTVGLTGNADIDNTPFTAQADSGVSHAQIARGSDFGDSNNQPFQGA
>NZ_CP012334.1|WP_066631322.1|45368_45674_-|DUF4148-domain-containing-protein
MKAKTIVSALILSFAAIGAAQAANSEPNNVPFQGVYGQASNSVSRTQVLGELQQARTAGLTGNADIDNTPFTAQADSGVRHAQIARGSDFGDSNNQPFQGA
>NZ_CP012334.1|WP_066631325.1|46087_46393_-|DUF4148-domain-containing-protein
MKAKTIVSALILSFAAIGAAQAANSEPNNVPFQGVYGQASNSVSRTQVLGELQQARTAGLTGNADIDNTPFTAQADSGVNHAQIARGSDFGDSNNQPFQGA
>NZ_CP012334.1|WP_083228547.1|46675_47353_-|FCD-domain-containing-protein
MEDIEPLDAGTPTLARMTYDRLRADVLGGLWQPGRKLLMHELRERYQVGASPLREALNRLASEQWVVHNDQRGFSVAQASQAQLDDLVATRISIESLALAQAFARRTPEWEEKLVLAFHRMTRTPRSVGQDSYEENPEWERLHRAFHLALLAGCGSPLLLGFCEQLYDQAYRYRQLAARKSYKQRKEMDEHRAVFDAVMEDRLGDAQRLLAEHYRRTASIYQGAT
>NZ_CP012334.1|WP_066631328.1|47435_48296_+|fumarylacetoacetate-hydrolase-family-protein
MAKLARIATQPGGPAQWAVQQGQDLLGLGDSVPAGEHDTAWLRLAAEGVPAAMLQRAARLDMDKVEWRMPVARPGKIICLGLNYAAHAAEGGNAKPEYPSFFMRGATSLIAHEAPLVRPKVSDKLDFEAELAVIIGQRARHLDESNALRAVAGYACFNDGTLRDYQRRTSQWTIGKNFDGTGAFGPWLVPAADLPPGAQGLKIQSRLNGQVMQSDDTGHMIVTVAHALTLLTEVLTLEPGDVIAMGTPAGVGYARTPPAWMQPGDRIEIDIENVGLLSNPIVQEDV
>NZ_CP012334.1|WP_066631331.1|48297_49146_+|polysaccharide-deacetylase-family-protein
MEPVITRLPDDFRWPGGHRVAVIFNIAYEAWSDGQAPGIGPMGNVLKPGYFDTNAHSWASFGLVRGIHRLLAIAERQGVKTSVMVNGVICERDPATVKRLAGLGHEIVNHSWGMDVIPVYLDEAGERANLARNHALLAGTAGVAPVGWISPRGTGSAITSRLLAEAGYLHHGDVNDDDRPYVMDFGGKRIVGIPLTMDVNDLPTCVRYGQGPRHMLDTFNDAFAALRAEPVPLMMDVTAHTHVMGRASGAWVYEEIIRRVKASGDVWICTREQMARHVLNAL

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP012334_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012334_2

118557-118652

Orphan

Consensus_repeat	Method
CCCCCTCAAGGGGGCGACGCCGGCGGACCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012334_2

>merge|NZ_CP012334|2|118557-118652|CRISPRCasFinder
CCCCCTCAAGGGGGCGACGCCGGCGGACCGGAAGAACGGATCCACCCCCGAAGCGCTGCGCGCTCCCCCCTCAAGGGGGCGACGCCGGCGGACCGG

>NZ_CP012334|2|2|118557-118652|CRISPRCasFinder
CCCCCTCAAGGGGGCGACGCCGGCGGACCGG	AAGAACGGATCCACCCCCGAAGCGCTGCGCGCTC
CCCCCTCAAGGGGGCGACGCCGGCGGACCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012334.1\|WP_083228551.1\|113468_114332_+\|VacJ-family-lipoprotein	unknown	unknown	gnl\|CDD\|377309
NZ_CP012334.1\|WP_066631458.1\|122038_122626_+\|imidazoleglycerol-phosphate-dehydratase-HisB	unknown	unknown	gnl\|CDD\|234873
NZ_CP012334.1\|WP_066631476.1\|125864_126215_+\|phosphoribosyl-ATP-diphosphatase	unknown	unknown	gnl\|CDD\|179005
NZ_CP012334.1\|WP_066631441.1\|114413_115037_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|377516
NZ_CP012334.1\|WP_066631456.1\|120820_121954_+\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|179888
NZ_CP012334.1\|WP_066631437.1\|111800_112601_+\|lipid-asymmetry-maintenance-ABC-transporter-permease-subunit-MlaE	unknown	unknown	gnl\|CDD\|223838
NZ_CP012334.1\|WP_066631435.1\|110367_110898_+\|chromate-transporter	unknown	unknown	gnl\|CDD\|376780
NZ_CP012334.1\|WP_066631445.1\|116007_116796_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|237896
NZ_CP012334.1\|WP_066631443.1\|115150_115948_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP012334.1\|WP_066631460.1\|122660_123335_+\|imidazole-glycerol-phosphate-synthase-subunit-HisH	unknown	unknown	gnl\|CDD\|237290
NZ_CP012334.1\|WP_066631470.1\|123419_124163_+\|1-(5-phosphoribosyl)-5-[(5--phosphoribosylamino)methylideneamino]imidazole-4--carboxamide-isomerase	unknown	unknown	gnl\|CDD\|179108
NZ_CP012334.1\|WP_066631448.1\|117035_117278_+\|BolA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|227340
NZ_CP012334.1\|WP_066631478.1\|126247_126616_+\|histidine-triad-nucleotide-binding-protein	unknown	unknown	gnl\|CDD\|238607
NZ_CP012334.1\|WP_066631474.1\|125463_125868_+\|phosphoribosyl-AMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234598
NZ_CP012334.1\|WP_066631439.1\|112835_113354_+\|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD	unknown	unknown	gnl\|CDD\|275223
NZ_CP012334.1\|WP_066631454.1\|119519_120824_+\|histidinol-dehydrogenase	unknown	unknown	gnl\|CDD\|234853
NZ_CP012334.1\|WP_066631436.1\|110967_111804_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213228
NZ_CP012334.1\|WP_066631472.1\|124159_124972_+\|imidazole-glycerol-phosphate-synthase-subunit-HisF	unknown	unknown	gnl\|CDD\|234996
NZ_CP012334.1\|WP_066631451.1\|117277_118531_+\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NZ_CP012334.1\|WP_066631453.1\|118733_119429_+\|ATP-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234971

Protein	Function_ID	Function_description	E-value
NZ_CP012334.1\|WP_083228551.1\|113468_114332_+\|VacJ-family-lipoprotein	gnl\|CDD\|377309	pfam04333, MlaA, MlaA lipoprotein. MlaA is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. MlaA is required for the intercellular spreading of Shigella flexneri. It is attached to the outer membrane by a lipid anchor.	2.94011e-98
NZ_CP012334.1\|WP_066631458.1\|122038_122626_+\|imidazoleglycerol-phosphate-dehydratase-HisB	gnl\|CDD\|234873	PRK00951, hisB, imidazoleglycerol-phosphate dehydratase HisB.	6.92138e-131
NZ_CP012334.1\|WP_066631476.1\|125864_126215_+\|phosphoribosyl-ATP-diphosphatase	gnl\|CDD\|179005	PRK00400, hisE, phosphoribosyl-ATP diphosphatase.	3.77669e-47
NZ_CP012334.1\|WP_066631441.1\|114413_115037_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|377516	pfam05494, MlaC, MlaC protein. MlaC is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. This family of proteins is involved in toluene tolerance, which is mediated by increased cell membrane rigidity resulting from changes in fatty acid and phospholipid compositions, exclusion of toluene from the cell membrane, and removal of intracellular toluene by degradation. Many proteins are involved in these processes.	4.07982e-64
NZ_CP012334.1\|WP_066631456.1\|120820_121954_+\|histidinol-phosphate-transaminase	gnl\|CDD\|179888	PRK04870, PRK04870, histidinol-phosphate transaminase.	0
NZ_CP012334.1\|WP_066631437.1\|111800_112601_+\|lipid-asymmetry-maintenance-ABC-transporter-permease-subunit-MlaE	gnl\|CDD\|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	2.22922e-83
NZ_CP012334.1\|WP_066631435.1\|110367_110898_+\|chromate-transporter	gnl\|CDD\|376780	pfam02417, Chromate_transp, Chromate transporter. Members of this family probably act as chromate transporters. Members of this family are found in both bacteria and archaebacteria. The proteins are composed of one or two copies of this region. The alignment contains two conserved motifs, FGG and PGP.	2.63252e-31
NZ_CP012334.1\|WP_066631445.1\|116007_116796_+\|ABC-transporter-permease	gnl\|CDD\|237896	PRK15066, PRK15066, inner membrane transport permease; Provisional.	7.55013e-67
NZ_CP012334.1\|WP_066631443.1\|115150_115948_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.09133e-90
NZ_CP012334.1\|WP_066631460.1\|122660_123335_+\|imidazole-glycerol-phosphate-synthase-subunit-HisH	gnl\|CDD\|237290	PRK13146, hisH, imidazole glycerol phosphate synthase subunit HisH; Provisional.	1.21031e-120
NZ_CP012334.1\|WP_066631470.1\|123419_124163_+\|1-(5-phosphoribosyl)-5-[(5--phosphoribosylamino)methylideneamino]imidazole-4--carboxamide-isomerase	gnl\|CDD\|179108	PRK00748, PRK00748, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Validated.	1.02075e-139
NZ_CP012334.1\|WP_066631448.1\|117035_117278_+\|BolA-family-transcriptional-regulator	gnl\|CDD\|227340	COG5007, COG5007, Predicted transcriptional regulator, BolA superfamily [Transcription].	4.36933e-34
NZ_CP012334.1\|WP_066631478.1\|126247_126616_+\|histidine-triad-nucleotide-binding-protein	gnl\|CDD\|238607	cd01276, PKCI_related, Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members.	1.79629e-55
NZ_CP012334.1\|WP_066631474.1\|125463_125868_+\|phosphoribosyl-AMP-cyclohydrolase	gnl\|CDD\|234598	PRK00051, hisI, phosphoribosyl-AMP cyclohydrolase; Reviewed.	1.64644e-77
NZ_CP012334.1\|WP_066631439.1\|112835_113354_+\|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD	gnl\|CDD\|275223	TIGR04430, OM_asym_MlaD, outer membrane lipid asymmetry maintenance protein MlaD. Members of this protein family are the MlaD (maintenance of Lipid Asymmetry D) protein of an ABC transport system that seems to remove phospholipid from the outer leaflet of the Gram-negative bacterial outer membrane (OM), leaving only lipopolysaccharide in the outer leaflet. The Mla locus has long been associated with toluene tolerance, consistent with the proposed role in retrograde transport of phospholipid and therefore with maintaining the integrity of the OM as a protective barrier.	3.84549e-83
NZ_CP012334.1\|WP_066631454.1\|119519_120824_+\|histidinol-dehydrogenase	gnl\|CDD\|234853	PRK00877, hisD, bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Reviewed.	0
NZ_CP012334.1\|WP_066631436.1\|110967_111804_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213228	cd03261, ABC_Org_Solvent_Resistant, ATP-binding cassette transport system involved in resistant to organic solvents. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.8002e-124
NZ_CP012334.1\|WP_066631472.1\|124159_124972_+\|imidazole-glycerol-phosphate-synthase-subunit-HisF	gnl\|CDD\|234996	PRK02083, PRK02083, imidazole glycerol phosphate synthase subunit HisF; Provisional.	2.37225e-174
NZ_CP012334.1\|WP_066631451.1\|117277_118531_+\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NZ_CP012334.1\|WP_066631453.1\|118733_119429_+\|ATP-phosphoribosyltransferase	gnl\|CDD\|234971	PRK01686, hisG, ATP phosphoribosyltransferase catalytic subunit; Reviewed.	4.49873e-130

>NZ_CP012334.1|WP_066631451.1|117277_118531_+|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MDKLRITGGTRLRGEIAVSGAKNAALPILCAGLLTADTLSLDNVPQLNDIATMLRLLDHVGARAERQADGGVAIRADQVDKLEAPYELVKTMRASILVLGPLVARFGEARVSLPGGCSIGQRPVDQHIKGLAALGADIKLEHGFVVARAKRLKGASIRTDMVTVTGTENLMMAATLAEGRTVLENAAREPEVVDLAELLIKMGARIQGHGTDRIVIDGVQRLHGATHRVIPDRIEAGTFLCAVAAAGGEITLRNTEAAHMGATLDKLTEAGVALETGADWIRASMRARPRAVSVRTHEYPGFATDMQAQFMALDAVAEGTGVIVENIFENRYMHVQELIRMGADIDIDGHTAVVRGVGGLSGATVMATDLRASASLVIGGLVADGETLVDRIYHLDRGYEQMEGKLRELGARIERER
>NZ_CP012334.1|WP_066631448.1|117035_117278_+|BolA-family-transcriptional-regulator
MLPTPEQVRQYIADGLPCEHIDVQGDGSHFDAVIVSAAFEGKRPIARHQLVYAALGDRMKAEIHALSMRTLTPAEYKAGR
>NZ_CP012334.1|WP_066631445.1|116007_116796_+|ABC-transporter-permease
MQPMLDAAGEAGSGFPTLLRKELMRFWKVSFQTIAAPVITALLYLLVFAQVLQDRVHVYGTVPYTSFLIPGLMMMSMLQNAFANPSSSLIQSRITGNLVFILLPPLSHRDIYFAYVIAAIARGIAVGLCVWIVALFFIPLAPAHPLWVFAFAVLACGIMGSLGVIAGLFSEKFDQLAAFQNFLIMPATFLSGVFYSIHTLPPFWQGVSHWNPIFYTIDGFRYGFFSVSDVSPWRSLAVVSCVFLALGTYAARLLATGYKLRN
>NZ_CP012334.1|WP_066631443.1|115150_115948_+|ABC-transporter-ATP-binding-protein
MSAVRLENVSKIYAARQPAWKKWLGRPSAPGFQALRNVNLDIQPGEFFGLLGPNGAGKTTLISVLAGLARPNSGSASVCGHDVQADFRQARRALGVVPQELVYDPFFTVRETLRIQSGYFGLRKNDDWIDEILFNLGLSDKADANMRALSGGMKRRVLVAQALVHRPPVIVLDEPTAGVDVDLRRTLWEFISRLNKAGHTIMLTTHYLEEAEALCGRIAMLKAGRIVALDTTPALLAGVGGVDLEDAFVRIMRREDDTQLTEVVS
>NZ_CP012334.1|WP_066631441.1|114413_115037_+|ABC-transporter-substrate-binding-protein
MRFHPLSLLQRLGIAGLLGLALAGSVHAAPSAKDAETLVQNTADKALQVLKTDGGVRSGELRRVNEVVNQYILPAVDFEKTTRLAAGRYWRQATPEQRTQLAEAFKGTLVRTYSGALSRVDNGTNIKVTGSAIDGNDAVVRSTVNQSNGQSVGVDYRLEQTPAGWKIYDLNVEGIWLIQNYRNQFANEINQNGIDGLIKALNQRNAQ
>NZ_CP012334.1|WP_083228551.1|113468_114332_+|VacJ-family-lipoprotein
MNKNTLTRIFAMAAAGAGLAGCATVQNPDPRDPWEGFNRGVYTFNDKVDRAVLRPIAVGYTKITPQPVQSCIHNMFNNVADIWAAANSMLQGRGIDAINTFGRFLFNTTMGVGGCFDVATANGANRIPNDFGTTLGVWGAGQGPYVVLPFWGSSTVRDTAGLAGDFVGNQWTSVGAIDNVPVRNSLYGLWVVDRRASLLDATDTVDRVALDPYSFVRDAYLQRRAAMVLGRKAGDANNLPNYDEDSEGTGDGGKPAGTGAGSGAPVPAAPGIGGAGAGSTTPAPKHQ
>NZ_CP012334.1|WP_066631439.1|112835_113354_+|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD
MSRQKTDFWVGLFVLLGAAALVFLALRAGNLSAFSFAPTYDLTAQFDNIGGLKERAAVKSAGVVVGRVSRIRFDDKNFQAVVTLSIDADFKFPKDSSAAILTAGLLGEQYVGLTAGGDDGDFADGDKIRYTQSAVVLENLISQFLYGTAEKQGSAPAGNAPAPAPAPAPQTH
>NZ_CP012334.1|WP_066631437.1|111800_112601_+|lipid-asymmetry-maintenance-ABC-transporter-permease-subunit-MlaE
MSDSHSASVGPISRLGGWVADTIGGIGYFTRFFGALLAKSGIALRRPRLVSQQVHFIGNYSLIIIAVSGMFVGFVLGLQGYYTLRRYGSEESLGLLVALSLVRELGPVVTALLFAGRAGTSLTAEIGLMKAGEQLAAMEVMAVDPMRRVLVPRLWGGIIAMPVLAAVFSMVGIMGGWLVGVVLIGVDAGAFWSQMQSGVDVWKDVANGVLKSIVFGVGVTLVALYEGWQARATPEGVARATTRTVVVGSLAVLALDFLLTALMFGN
>NZ_CP012334.1|WP_066631436.1|110967_111804_+|ABC-transporter-ATP-binding-protein
MPTDPDARTVQALKFTDVSLGYGDFTVLQGISMTVAPGQVIAVMGGSGSGKTTMLRAATGQLQARTGQVQVFGHDMSRVSPDELQSLRKRMGVLFQQGALFTDLDVFENVAFPLREHTAYSEAEVLERVLDKLHAVGLRAAAHLQVSEISGGMARRVALARAVVLEPELILYDEPFAGLDPISMGITARLIRDLSDRLKCASVLITHDVQESFSIADQVYLVGQGRLVASGRPDELSASTDPYVRQFLHGEPDGPVAFHYPDTPAFDRWLARQEGRRP
>NZ_CP012334.1|WP_066631435.1|110367_110898_+|chromate-transporter
MTGGSALWDLFAVFAPLSFLTVGGGQSVVADIHRQAVDVYGWMNDAQFLDLFALSRITPGPGSLLVTLVGWQVRGVLGAVVASFAIFVPSTVLIYALARVWQRYNGRLWIRAIESGLAPVAAGMILAASCTILRAAEGGAWAWAVAIASTLLLLRTRVSPFLLLGGGALVFLVALR
>NZ_CP012334.1|WP_066631453.1|118733_119429_+|ATP-phosphoribosyltransferase
MKNQPNTPAADPAPLTLALSKGRIFEETLPLLAEAGIEVAENPERSRKLIIPTSDPGLRLIIVRASDVPTYVQYGAADLGIAGKDVLIEHAAAHPGGLYQPIDLNIAKCRLCVAVPAGFDYQNAVRQGARLRVATKYVQAAREHFAAKGVYVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLRANNLVAVEDIMPISSRLVVNQAALKTRGARLQPLLDAFERASAAPVA
>NZ_CP012334.1|WP_066631454.1|119519_120824_+|histidinol-dehydrogenase
MTTINRLDSRDPGFASALSSLLAFEASQDESIDRAAADILADVRHRGDAALLEYTRRFDRVEVDGVQGLEIPRDSWHAALESLPAAQRQGLEAAAQRVRAYHERQRGQTWTYTEADGTMLGQKITPLDRVGLYVPGGKAAYPSSVLMNAIPAKVAGVPELIMVTPTPDGMRNPMVLAAAAIAGVDRAFAIGGAQAVGALAYGTATIPAVDKIVGPGNAYVAAAKRRVFGTVGIDMIAGPSEILVICDGQTPADWIAMDLFSQAEHDELAQAILLCPDAAYLDAVAASIERQLPGMPRAAILRESLGKRGALIQVRSLEEACDIANDIAPEHLEISTDNPEKWVERIRHAGAIFMGRYASESLGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSLIQVSRQGAQTLGRIAADLAYGEGLQAHAASAEYRLDKA
>NZ_CP012334.1|WP_066631456.1|120820_121954_+|histidinol-phosphate-transaminase
MTAAAPGRGPADGGPPASAAERAAATIRPDIQALSAYAVGHADDGIKLDAMENPYGLPDEVRDAIAAAARATALNRYPAAHHDALQAAVRAAFGVPDAAALLFGNGSDELISLIVQACCDAGDTVLSPVPSFVMFEMSARFHHARFVGVPLTPNFELDLPAMLAAIRAHRPKVVFLAVPNNPTGGRWTDAAIDAILAAAPGLVVIDEAYQPFADGTWMPRAATLPNAVVLRTVSKIGLAGLRFGYLAGPAPWITEIDKLRPPYNVDVLTEAVMLAVLRHKAVLDEQAARLRDSRDGLARALAALPGVIVYPSSANFLLARFSGKMSGNAVHQALKTRKIRVRNFPGGEPALADCLRISLGTPDEHAALLTALHDILA
>NZ_CP012334.1|WP_066631458.1|122038_122626_+|imidazoleglycerol-phosphate-dehydratase-HisB
MRTADITRNTNETRIRVAVNLDGTGRQSIDTGVPFLDHMLDQIARHGLIDLDIKAEGDLHIDAHHTVEDVGITLGQAIAAAIGDKKGILRYGHAYVPLDEALSRVVVDFSGRPGLEFNVPFTRARIGEFDVDLTREFFQGLVNHALITMHIDNLRGRNAHHQCETVFKACGRALRMAMERDPRSQGVVPSTKGVL
>NZ_CP012334.1|WP_066631460.1|122660_123335_+|imidazole-glycerol-phosphate-synthase-subunit-HisH
MTSIAIVDYGMGNFHSVARALAAAAPDADIRISNTAADIDAADRVVFPGQGAMADCMRTLNESGLREAVVRAARSKPLLGVCVGEQMLFDTSEEGPTICLGIFPGVVHRFSGAQYAPPIGAYEDPATTAAAGERLKVPHMGWNKVRQTHSHPIWAGIPDGTHFYFVHSYYAVPADPALTVGESDYGGSFTCAVAAANIFAVQFHPEKSAEHGLRLYRNFVDWRP
>NZ_CP012334.1|WP_066631470.1|123419_124163_+|1-(5-phosphoribosyl)-5-[(5--phosphoribosylamino)methylideneamino]imidazole-4--carboxamide-isomerase
MLLIPAIDLKDGRCVRLRQGDLDDATVFSEDPAAMATHWLEQGARRLHLVDLNGAVAGKPRNEASIKAIVDAVGDEIPVQIGGGIRDLDTIERYLDNGISYVIIGTAAVKNPGFLHDACGAFPGSIIVGLDARDGKVATDGWSKLTRHDVLDLASKFEDYGCEAIIYTDIGRDGMLSGVNVDATVRLAQHVRIPIFASGGIAGIQDIEALCAVEEEGVEGAILGRSIYEGALDFQAAQTRADELAKP
>NZ_CP012334.1|WP_066631472.1|124159_124972_+|imidazole-glycerol-phosphate-synthase-subunit-HisF
MNGITPSGAGAGANTLTRRIIPCLDVTAGRVVKGVNFVNLVDAGDPVEIARRYNEQGADELTFLDITATSDGRDLILPIIEQVASQVFIPLTVGGGVRQVSDIQRLLNAGADKVSINSAAVANPELVRAAADYHGSQCIVVAIDARRAKTEDGGERWEVFTHGGRKATGLDAIEWARRMAEYGAGEILLTSMDKDGTKSGFDLALTRAVSDAVPVPVIASGGVGSLQHLADGVTVGRANAVLAASIFHYGQHTVQECKRFMSDLGIEVRV
>NZ_CP012334.1|WP_066631474.1|125463_125868_+|phosphoribosyl-AMP-cyclohydrolase
MSNDPAWLGDVVFDAQGLIPAIAQDAQTGQILMVAWMNRESLAETAATGRAVYWSRSRQRLWRKGEESGHAQQVKELRLDCDGDVVLLKVDQQGGIACHTGRASCFFRRLDGQDGERHWETTDPVLKDPELIYK
>NZ_CP012334.1|WP_066631476.1|125864_126215_+|phosphoribosyl-ATP-diphosphatase
MSNIDPRGEAVLARIADTLETRRPDRGGDPASSYAARLLAKAPDAFLKKIGEEATELVMAAKDGLPERIVSETADLWFHCLVALTHYNLRPEDVLAELARREGLSGLAEKAARPAD
>NZ_CP012334.1|WP_066631478.1|126247_126616_+|histidine-triad-nucleotide-binding-protein
MSDNCIFCKISRGEIPAKKVYEDDEFVAFHDINPAAPVHLLLITRRHIASLQDVTADDGGWLGRMVTLAPRLALENGCNPGEQGGFRLLANSGAEGGQEVPHLHFHIIGGSRPWKGRVAPNA

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP012334_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012334_3

124990-125086

Orphan

Consensus_repeat	Method
CCCACCCCCGAACGCTGCGCGCTTCCCCCTCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012334_3

>merge|NZ_CP012334|3|124990-125086|CRISPRCasFinder
CCCACCCCCGAACGCTGCGCGCTTCCCCCTCAAGGGGGCGACGCCGGCGGACCGGAAGGAAGACCCACCCCCGAAGCGCTGCGCGCTTCCCCCTCAA

>NZ_CP012334|3|3|124990-125086|CRISPRCasFinder
CCCACCCCCGAACGCTGCGCGCTTCCCCCTCAA	GGGGGCGACGCCGGCGGACCGGAAGGAAGAC
CCACCCCCGAAGCGCTGCGCGCTTCCCCCTCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012334.1\|WP_066631458.1\|122038_122626_+\|imidazoleglycerol-phosphate-dehydratase-HisB	unknown	unknown	gnl\|CDD\|234873
NZ_CP012334.1\|WP_066631494.1\|131054_131504_-\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|237569
NZ_CP012334.1\|WP_066631476.1\|125864_126215_+\|phosphoribosyl-ATP-diphosphatase	unknown	unknown	gnl\|CDD\|179005
NZ_CP012334.1\|WP_066631488.1\|128564_128990_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NZ_CP012334.1\|WP_066631492.1\|130134_130911_+\|Nif3-like-dinuclear-metal-center-hexameric-protein	unknown	unknown	gnl\|CDD\|182741
NZ_CP012334.1\|WP_066631485.1\|127712_128504_+\|twin-arginine-translocase-subunit-TatC	unknown	unknown	gnl\|CDD\|182840
NZ_CP012334.1\|WP_066631482.1\|126975_127716_+\|Sec-independent-protein-translocase-subunit-TatB	unknown	unknown	gnl\|CDD\|234992
NZ_CP012334.1\|WP_066631445.1\|116007_116796_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|237896
NZ_CP012334.1\|WP_066631480.1\|126631_126856_+\|Sec-independent-protein-translocase-subunit-TatA	unknown	unknown	gnl\|CDD\|235091
NZ_CP012334.1\|WP_066631460.1\|122660_123335_+\|imidazole-glycerol-phosphate-synthase-subunit-HisH	unknown	unknown	gnl\|CDD\|237290
NZ_CP012334.1\|WP_066631470.1\|123419_124163_+\|1-(5-phosphoribosyl)-5-[(5--phosphoribosylamino)methylideneamino]imidazole-4--carboxamide-isomerase	unknown	unknown	gnl\|CDD\|179108
NZ_CP012334.1\|WP_066631456.1\|120820_121954_+\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|179888
NZ_CP012334.1\|WP_066631478.1\|126247_126616_+\|histidine-triad-nucleotide-binding-protein	unknown	unknown	gnl\|CDD\|238607
NZ_CP012334.1\|WP_066631474.1\|125463_125868_+\|phosphoribosyl-AMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234598
NZ_CP012334.1\|WP_066631490.1\|128949_130116_-\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|273938
NZ_CP012334.1\|WP_066631454.1\|119519_120824_+\|histidinol-dehydrogenase	unknown	unknown	gnl\|CDD\|234853
NZ_CP012334.1\|WP_066631448.1\|117035_117278_+\|BolA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|227340
NZ_CP012334.1\|WP_066631472.1\|124159_124972_+\|imidazole-glycerol-phosphate-synthase-subunit-HisF	unknown	unknown	gnl\|CDD\|234996
NZ_CP012334.1\|WP_066631451.1\|117277_118531_+\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NZ_CP012334.1\|WP_066631453.1\|118733_119429_+\|ATP-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234971

Protein	Function_ID	Function_description	E-value
NZ_CP012334.1\|WP_066631458.1\|122038_122626_+\|imidazoleglycerol-phosphate-dehydratase-HisB	gnl\|CDD\|234873	PRK00951, hisB, imidazoleglycerol-phosphate dehydratase HisB.	6.92138e-131
NZ_CP012334.1\|WP_066631494.1\|131054_131504_-\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|237569	PRK13952, mscL, large conductance mechanosensitive channel protein MscL.	8.80638e-72
NZ_CP012334.1\|WP_066631476.1\|125864_126215_+\|phosphoribosyl-ATP-diphosphatase	gnl\|CDD\|179005	PRK00400, hisE, phosphoribosyl-ATP diphosphatase.	3.77669e-47
NZ_CP012334.1\|WP_066631488.1\|128564_128990_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	1.05443e-07
NZ_CP012334.1\|WP_066631492.1\|130134_130911_+\|Nif3-like-dinuclear-metal-center-hexameric-protein	gnl\|CDD\|182741	PRK10799, PRK10799, type 2 GTP cyclohydrolase I.	2.49703e-94
NZ_CP012334.1\|WP_066631485.1\|127712_128504_+\|twin-arginine-translocase-subunit-TatC	gnl\|CDD\|182840	PRK10921, PRK10921, Sec-independent protein translocase subunit TatC.	2.92507e-83
NZ_CP012334.1\|WP_066631482.1\|126975_127716_+\|Sec-independent-protein-translocase-subunit-TatB	gnl\|CDD\|234992	PRK01919, tatB, Sec-independent protein translocase subunit TatB.	1.6089e-40
NZ_CP012334.1\|WP_066631445.1\|116007_116796_+\|ABC-transporter-permease	gnl\|CDD\|237896	PRK15066, PRK15066, inner membrane transport permease; Provisional.	7.55013e-67
NZ_CP012334.1\|WP_066631480.1\|126631_126856_+\|Sec-independent-protein-translocase-subunit-TatA	gnl\|CDD\|235091	PRK02958, tatA, Sec-independent protein translocase subunit TatA.	1.95278e-41
NZ_CP012334.1\|WP_066631460.1\|122660_123335_+\|imidazole-glycerol-phosphate-synthase-subunit-HisH	gnl\|CDD\|237290	PRK13146, hisH, imidazole glycerol phosphate synthase subunit HisH; Provisional.	1.21031e-120
NZ_CP012334.1\|WP_066631470.1\|123419_124163_+\|1-(5-phosphoribosyl)-5-[(5--phosphoribosylamino)methylideneamino]imidazole-4--carboxamide-isomerase	gnl\|CDD\|179108	PRK00748, PRK00748, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Validated.	1.02075e-139
NZ_CP012334.1\|WP_066631456.1\|120820_121954_+\|histidinol-phosphate-transaminase	gnl\|CDD\|179888	PRK04870, PRK04870, histidinol-phosphate transaminase.	0
NZ_CP012334.1\|WP_066631478.1\|126247_126616_+\|histidine-triad-nucleotide-binding-protein	gnl\|CDD\|238607	cd01276, PKCI_related, Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members.	1.79629e-55
NZ_CP012334.1\|WP_066631474.1\|125463_125868_+\|phosphoribosyl-AMP-cyclohydrolase	gnl\|CDD\|234598	PRK00051, hisI, phosphoribosyl-AMP cyclohydrolase; Reviewed.	1.64644e-77
NZ_CP012334.1\|WP_066631490.1\|128949_130116_-\|trypsin-like-serine-protease	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	3.18766e-139
NZ_CP012334.1\|WP_066631454.1\|119519_120824_+\|histidinol-dehydrogenase	gnl\|CDD\|234853	PRK00877, hisD, bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Reviewed.	0
NZ_CP012334.1\|WP_066631448.1\|117035_117278_+\|BolA-family-transcriptional-regulator	gnl\|CDD\|227340	COG5007, COG5007, Predicted transcriptional regulator, BolA superfamily [Transcription].	4.36933e-34
NZ_CP012334.1\|WP_066631472.1\|124159_124972_+\|imidazole-glycerol-phosphate-synthase-subunit-HisF	gnl\|CDD\|234996	PRK02083, PRK02083, imidazole glycerol phosphate synthase subunit HisF; Provisional.	2.37225e-174
NZ_CP012334.1\|WP_066631451.1\|117277_118531_+\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NZ_CP012334.1\|WP_066631453.1\|118733_119429_+\|ATP-phosphoribosyltransferase	gnl\|CDD\|234971	PRK01686, hisG, ATP phosphoribosyltransferase catalytic subunit; Reviewed.	4.49873e-130

>NZ_CP012334.1|WP_066631472.1|124159_124972_+|imidazole-glycerol-phosphate-synthase-subunit-HisF
MNGITPSGAGAGANTLTRRIIPCLDVTAGRVVKGVNFVNLVDAGDPVEIARRYNEQGADELTFLDITATSDGRDLILPIIEQVASQVFIPLTVGGGVRQVSDIQRLLNAGADKVSINSAAVANPELVRAAADYHGSQCIVVAIDARRAKTEDGGERWEVFTHGGRKATGLDAIEWARRMAEYGAGEILLTSMDKDGTKSGFDLALTRAVSDAVPVPVIASGGVGSLQHLADGVTVGRANAVLAASIFHYGQHTVQECKRFMSDLGIEVRV
>NZ_CP012334.1|WP_066631470.1|123419_124163_+|1-(5-phosphoribosyl)-5-[(5--phosphoribosylamino)methylideneamino]imidazole-4--carboxamide-isomerase
MLLIPAIDLKDGRCVRLRQGDLDDATVFSEDPAAMATHWLEQGARRLHLVDLNGAVAGKPRNEASIKAIVDAVGDEIPVQIGGGIRDLDTIERYLDNGISYVIIGTAAVKNPGFLHDACGAFPGSIIVGLDARDGKVATDGWSKLTRHDVLDLASKFEDYGCEAIIYTDIGRDGMLSGVNVDATVRLAQHVRIPIFASGGIAGIQDIEALCAVEEEGVEGAILGRSIYEGALDFQAAQTRADELAKP
>NZ_CP012334.1|WP_066631460.1|122660_123335_+|imidazole-glycerol-phosphate-synthase-subunit-HisH
MTSIAIVDYGMGNFHSVARALAAAAPDADIRISNTAADIDAADRVVFPGQGAMADCMRTLNESGLREAVVRAARSKPLLGVCVGEQMLFDTSEEGPTICLGIFPGVVHRFSGAQYAPPIGAYEDPATTAAAGERLKVPHMGWNKVRQTHSHPIWAGIPDGTHFYFVHSYYAVPADPALTVGESDYGGSFTCAVAAANIFAVQFHPEKSAEHGLRLYRNFVDWRP
>NZ_CP012334.1|WP_066631458.1|122038_122626_+|imidazoleglycerol-phosphate-dehydratase-HisB
MRTADITRNTNETRIRVAVNLDGTGRQSIDTGVPFLDHMLDQIARHGLIDLDIKAEGDLHIDAHHTVEDVGITLGQAIAAAIGDKKGILRYGHAYVPLDEALSRVVVDFSGRPGLEFNVPFTRARIGEFDVDLTREFFQGLVNHALITMHIDNLRGRNAHHQCETVFKACGRALRMAMERDPRSQGVVPSTKGVL
>NZ_CP012334.1|WP_066631456.1|120820_121954_+|histidinol-phosphate-transaminase
MTAAAPGRGPADGGPPASAAERAAATIRPDIQALSAYAVGHADDGIKLDAMENPYGLPDEVRDAIAAAARATALNRYPAAHHDALQAAVRAAFGVPDAAALLFGNGSDELISLIVQACCDAGDTVLSPVPSFVMFEMSARFHHARFVGVPLTPNFELDLPAMLAAIRAHRPKVVFLAVPNNPTGGRWTDAAIDAILAAAPGLVVIDEAYQPFADGTWMPRAATLPNAVVLRTVSKIGLAGLRFGYLAGPAPWITEIDKLRPPYNVDVLTEAVMLAVLRHKAVLDEQAARLRDSRDGLARALAALPGVIVYPSSANFLLARFSGKMSGNAVHQALKTRKIRVRNFPGGEPALADCLRISLGTPDEHAALLTALHDILA
>NZ_CP012334.1|WP_066631454.1|119519_120824_+|histidinol-dehydrogenase
MTTINRLDSRDPGFASALSSLLAFEASQDESIDRAAADILADVRHRGDAALLEYTRRFDRVEVDGVQGLEIPRDSWHAALESLPAAQRQGLEAAAQRVRAYHERQRGQTWTYTEADGTMLGQKITPLDRVGLYVPGGKAAYPSSVLMNAIPAKVAGVPELIMVTPTPDGMRNPMVLAAAAIAGVDRAFAIGGAQAVGALAYGTATIPAVDKIVGPGNAYVAAAKRRVFGTVGIDMIAGPSEILVICDGQTPADWIAMDLFSQAEHDELAQAILLCPDAAYLDAVAASIERQLPGMPRAAILRESLGKRGALIQVRSLEEACDIANDIAPEHLEISTDNPEKWVERIRHAGAIFMGRYASESLGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSLIQVSRQGAQTLGRIAADLAYGEGLQAHAASAEYRLDKA
>NZ_CP012334.1|WP_066631453.1|118733_119429_+|ATP-phosphoribosyltransferase
MKNQPNTPAADPAPLTLALSKGRIFEETLPLLAEAGIEVAENPERSRKLIIPTSDPGLRLIIVRASDVPTYVQYGAADLGIAGKDVLIEHAAAHPGGLYQPIDLNIAKCRLCVAVPAGFDYQNAVRQGARLRVATKYVQAAREHFAAKGVYVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLRANNLVAVEDIMPISSRLVVNQAALKTRGARLQPLLDAFERASAAPVA
>NZ_CP012334.1|WP_066631451.1|117277_118531_+|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MDKLRITGGTRLRGEIAVSGAKNAALPILCAGLLTADTLSLDNVPQLNDIATMLRLLDHVGARAERQADGGVAIRADQVDKLEAPYELVKTMRASILVLGPLVARFGEARVSLPGGCSIGQRPVDQHIKGLAALGADIKLEHGFVVARAKRLKGASIRTDMVTVTGTENLMMAATLAEGRTVLENAAREPEVVDLAELLIKMGARIQGHGTDRIVIDGVQRLHGATHRVIPDRIEAGTFLCAVAAAGGEITLRNTEAAHMGATLDKLTEAGVALETGADWIRASMRARPRAVSVRTHEYPGFATDMQAQFMALDAVAEGTGVIVENIFENRYMHVQELIRMGADIDIDGHTAVVRGVGGLSGATVMATDLRASASLVIGGLVADGETLVDRIYHLDRGYEQMEGKLRELGARIERER
>NZ_CP012334.1|WP_066631448.1|117035_117278_+|BolA-family-transcriptional-regulator
MLPTPEQVRQYIADGLPCEHIDVQGDGSHFDAVIVSAAFEGKRPIARHQLVYAALGDRMKAEIHALSMRTLTPAEYKAGR
>NZ_CP012334.1|WP_066631445.1|116007_116796_+|ABC-transporter-permease
MQPMLDAAGEAGSGFPTLLRKELMRFWKVSFQTIAAPVITALLYLLVFAQVLQDRVHVYGTVPYTSFLIPGLMMMSMLQNAFANPSSSLIQSRITGNLVFILLPPLSHRDIYFAYVIAAIARGIAVGLCVWIVALFFIPLAPAHPLWVFAFAVLACGIMGSLGVIAGLFSEKFDQLAAFQNFLIMPATFLSGVFYSIHTLPPFWQGVSHWNPIFYTIDGFRYGFFSVSDVSPWRSLAVVSCVFLALGTYAARLLATGYKLRN
>NZ_CP012334.1|WP_066631474.1|125463_125868_+|phosphoribosyl-AMP-cyclohydrolase
MSNDPAWLGDVVFDAQGLIPAIAQDAQTGQILMVAWMNRESLAETAATGRAVYWSRSRQRLWRKGEESGHAQQVKELRLDCDGDVVLLKVDQQGGIACHTGRASCFFRRLDGQDGERHWETTDPVLKDPELIYK
>NZ_CP012334.1|WP_066631476.1|125864_126215_+|phosphoribosyl-ATP-diphosphatase
MSNIDPRGEAVLARIADTLETRRPDRGGDPASSYAARLLAKAPDAFLKKIGEEATELVMAAKDGLPERIVSETADLWFHCLVALTHYNLRPEDVLAELARREGLSGLAEKAARPAD
>NZ_CP012334.1|WP_066631478.1|126247_126616_+|histidine-triad-nucleotide-binding-protein
MSDNCIFCKISRGEIPAKKVYEDDEFVAFHDINPAAPVHLLLITRRHIASLQDVTADDGGWLGRMVTLAPRLALENGCNPGEQGGFRLLANSGAEGGQEVPHLHFHIIGGSRPWKGRVAPNA
>NZ_CP012334.1|WP_066631480.1|126631_126856_+|Sec-independent-protein-translocase-subunit-TatA
MGSFSIWHWLIVLVIVALIFGTKKLRNFGSDLGGAVKGFKEGMRDANGDPVDPAQQQRVSGDTIDVQAKEKTHS
>NZ_CP012334.1|WP_066631482.1|126975_127716_+|Sec-independent-protein-translocase-subunit-TatB
MFDVSFTELMVIGVIALIVIGPERLPKVARTVGHLLGRAQRYVNDVKSDIRREIELDELRKFKTDMETAAQSVQTSLRDAETSLREPAQALRQELDEAAKAATSAVSMQSPATAALSESPAADAAHTLPQVAATPASAGASVATAAEAVPAATPAGSAPAVPEPAVSTPAPPAQAPASAQASPTPTPSPTPTPTPSSAPTATATATSPSSPPAVSASAPAPTPATPAASAAVDAAPTSPTPTGSAT
>NZ_CP012334.1|WP_066631485.1|127712_128504_+|twin-arginine-translocase-subunit-TatC
MSQELPQEEELQEDSFMSHLVELRTRLLRAVAVIGVFFVILFFYPGAAKIYDLLARPMLASLPEGTRMIATGVITPFMVPVKVTLMAAFVLSLPVVLWQAWAFVAPGLYRHEKRLALPLIVSSTFLFLAGMAFCYFVVFRTVFHFIATFAPQSITPAPDIEAYLSFVMTMFLAFGITFEVPVAVVLLVKAGIVDVKKLSSARGYVVVGAFIIAAVVTPPDVVSQFMLAVPLCLLFEVGLICARMVSKNSPKDQESENALTERQ
>NZ_CP012334.1|WP_066631488.1|128564_128990_+|helix-turn-helix-transcriptional-regulator
MTMADRLRTLMRWRGIRSQRQLARLSGVPQTSIHRILTRDPGYMPALGTLTRLARTLDTTVLWLSEGDAALRPAAHAAAPPQVREPDAAHHYHPECGGDAAELHMLMARLSDAERRHVVALVRMLADRPTWAAGDARRSSP
>NZ_CP012334.1|WP_066631490.1|128949_130116_-|trypsin-like-serine-protease
MRRLWLIFAQAVTVSLAILFVVSTLRPDWLRLGGPAAPPAPAPSRPDAAALPAAARGGGLSFAPAVARAAPAVVNVYTAKHVDVPLIPLPDDPVIRELLGQLPSVSRRHESTSLGSGVIVQDRYVLTNYHVVEAADAIEVALADGRETRAEVVGADPETDLAVLKLPEHIGAVPVATLGSDGALKVGDIVLAIGNPFGVGQTTTQGIVSALGRSSLGLNTYENFIQTDAAINPGNSGGALIDQRGNVVGINTAIYSQSGGSLGIGFAVPIDTARSVMDEIIRTGYVRRGWLGVEPQDLTPDLARAFKLGNQRGVIIAGVMRDGPAGRGGLRVGDIVLSIDGNDVRNTSSMLAMIALLPPGQEVALSVLRGGRPMELKVKIGVRPQRPR
>NZ_CP012334.1|WP_066631492.1|130134_130911_+|Nif3-like-dinuclear-metal-center-hexameric-protein
MNSIDTRELAAWLDQTLQPGRFRDYAPNGLQVEGKASIGHIIAGVTASEALLRTAIDRGADAVLVHHGWFWKNEDPRVRGPRRTRLALALGHDLNLFAYHLPLDAHPQLGNNAQLARVLGLVPDLDAAGQPRTCGPDSLVWLGSAPGIDDFGQLAARAAQRLGRQPQAIGDPQRPIRRVAWCTGGAQGMLADAVDAGVDAYITGEISEPTVHLSRETGVAFLAAGHHATERYGVQALGQAIADRFGIRVDFVDIDNPV
>NZ_CP012334.1|WP_066631494.1|131054_131504_-|large-conductance-mechanosensitive-channel-protein-MscL
MSFLKDFRNFAVKGNAVDLAVGVIIGAAFGRIVDSLVKDIVMPLLNLILGGAVDFSNKFIVLSMPPNYSGPMTYADLTKAGANVFAWGNFITIVINFVLLAFIIFWMVKAVARARTHLDASPAATPADVQLLQEIRDLLKQQQARGPVA

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Crispr_ID: NZ_CP012334_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012334_4

282376-282484

Orphan

Consensus_repeat	Method
TGGGAGGGCGCGCGCCCTTCGGGCGGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012334_4

>merge|NZ_CP012334|4|282376-282484|CRISPRCasFinder
TGGGAGGGCGCGCGCCCTTCGGGCGGCCATGCGCTCGCGGTCATTGGTATACCCCCCTGTCGCCGCGCGACATCCTCCTCATGGGAGGGCGCGCGCCCGTCGGGCGGCC

>NZ_CP012334|4|4|282376-282484|CRISPRCasFinder
TGGGAGGGCGCGCGCCCTTCGGGCGGCC	ATGCGCTCGCGGTCATTGGTATACCCCCCTGTCGCCGCGCGACATCCTCCTCA
TGGGAGGGCGCGCGCCCGTCGGGCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012334.1\|WP_066631731.1\|280271_282338_-\|TRAP-transporter-fused-permease-subunit	unknown	unknown	gnl\|CDD\|273983
NZ_CP012334.1\|WP_066631724.1\|271572_272637_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270307
NZ_CP012334.1\|WP_066631739.1\|287501_288425_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP012334.1\|WP_083229050.1\|298541_300533_-\|PAS-domain-containing-hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|237425
NZ_CP012334.1\|WP_066631720.1\|270494_271517_+\|cobalamin-biosynthesis-protein-CobW	unknown	unknown	gnl\|CDD\|223597
NZ_CP012334.1\|WP_083228565.1\|272733_275712_-\|autotransporter-domain-containing-protein	unknown	unknown	gnl\|CDD\|226973
NZ_CP012334.1\|WP_066631735.1\|284744_285590_-\|copper-resistance-protein-B	unknown	unknown	gnl\|CDD\|377498
NZ_CP012334.1\|WP_066631730.1\|278415_279618_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP012334.1\|WP_066631732.1\|282511_283483_-\|TAXI-family-TRAP-transporter-solute-binding-subunit	unknown	unknown	gnl\|CDD\|270287
NZ_CP012334.1\|WP_066631714.1\|265632_266709_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_CP012334.1\|WP_066631716.1\|267652_268900_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NZ_CP012334.1\|WP_083229049.1\|288578_292262_+\|exodeoxyribonuclease-V-subunit-gamma	unknown	unknown	gnl\|CDD\|273633
NZ_CP012334.1\|WP_083228564.1\|268903_270517_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NZ_CP012334.1\|WP_083228567.1\|296267_298538_+\|exodeoxyribonuclease-V-subunit-alpha	unknown	unknown	gnl\|CDD\|236783
NZ_CP012334.1\|WP_066641934.1\|300732_301620_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176109
NZ_CP012334.1\|WP_083228563.1\|266719_267622_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224097
NZ_CP012334.1\|WP_066631733.1\|283874_284621_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012334.1\|WP_083228566.1\|292254_296268_+\|exodeoxyribonuclease-V-subunit-beta	unknown	unknown	gnl\|CDD\|236784
NZ_CP012334.1\|WP_066631728.1\|275853_278082_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|377178
NZ_CP012334.1\|WP_066631737.1\|285586_287449_-\|copper-resistance-system-multicopper-oxidase	unknown	unknown	gnl\|CDD\|273649

Protein	Function_ID	Function_description	E-value
NZ_CP012334.1\|WP_066631731.1\|280271_282338_-\|TRAP-transporter-fused-permease-subunit	gnl\|CDD\|273983	TIGR02123, conserved_inner_membrane_protein, TRAP transporter, 4TM/12TM fusion protein. In some species, the 12-transmembrane spanning and 4-transmembrane spanning components of tripartite ATP-independent periplasmic (TRAP)-type transporters are fused. This model describes such transporters, found in the Archaea and in Bacteria. [Transport and binding proteins, Unknown substrate].	3.40818e-153
NZ_CP012334.1\|WP_066631724.1\|271572_272637_+\|extracellular-solute-binding-protein	gnl\|CDD\|270307	cd13589, PBP2_polyamine_RpCGA009, The periplasmic-binding component of an uncharacterized ABC transport system from Rhodopseudomonas palustris CGA009 and related proteins; contains the type 2 periplasmic-binding fold. This group represents the periplasmic binding domain that serves as the primary high-affinity receptor of an uncharacterized ABC-type polyamine transporter from Rhodopseudomonas palustris Cga009 and related proteins from other bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, and plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.52324e-60
NZ_CP012334.1\|WP_066631739.1\|287501_288425_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.42036e-68
NZ_CP012334.1\|WP_083229050.1\|298541_300533_-\|PAS-domain-containing-hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|237425	PRK13557, PRK13557, histidine kinase; Provisional.	2.77716e-111
NZ_CP012334.1\|WP_066631720.1\|270494_271517_+\|cobalamin-biosynthesis-protein-CobW	gnl\|CDD\|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	1.13616e-52
NZ_CP012334.1\|WP_083228565.1\|272733_275712_-\|autotransporter-domain-containing-protein	gnl\|CDD\|226973	COG4625, COG4625, Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown].	1.43315e-69
NZ_CP012334.1\|WP_066631735.1\|284744_285590_-\|copper-resistance-protein-B	gnl\|CDD\|377498	pfam05275, CopB, Copper resistance protein B precursor (CopB). This family consists of several bacterial copper resistance proteins. Copper is essential and serves as cofactor for more than 30 enzymes yet a surplus of copper is toxic and leads to radical formation and oxidation of biomolecules. Therefore, copper homeostasis is a key requisite for every organism. CopB serves to extrude copper when it approaches toxic levels.	1.34573e-98
NZ_CP012334.1\|WP_066631730.1\|278415_279618_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	6.21009e-104
NZ_CP012334.1\|WP_066631732.1\|282511_283483_-\|TAXI-family-TRAP-transporter-solute-binding-subunit	gnl\|CDD\|270287	cd13569, PBP2_TAXI_TRAP_like_1, Substrate binding domain of putative TAXI proteins of the tripartite ATP-independent periplasmic transporters; the type 2 periplasmic binding protein fold. This subgroup includes uncharacterized periplasmic binding proteins that are related to Thermus thermophilus GluBP (TtGluBP) of TAXI-TRAP family. TRAP transporters are comprised of an SBP (substrate-binding protein) and two unequally sized integral membrane components. Although TtGluBP is predicted to be an L-glutamate and/or an L-glutamine-binding protein, the substrate spectrum of TAXI proteins remains to be defined. A sequence-homology search also shows that TtGluBP shares low sequence homology with putative immunogenic proteins of uncharacterized function.	3.42335e-132
NZ_CP012334.1\|WP_066631714.1\|265632_266709_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	2.18123e-158
NZ_CP012334.1\|WP_066631716.1\|267652_268900_+\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	1.9634e-140
NZ_CP012334.1\|WP_083229049.1\|288578_292262_+\|exodeoxyribonuclease-V-subunit-gamma	gnl\|CDD\|273633	TIGR01450, recC, exodeoxyribonuclease V, gamma subunit. This model describes the gamma subunit of exodeoxyribonuclease V. Species containing this protein should also have the alpha (TIGR01447) and beta (TIGR00609) subunits. Candidates from Borrelia and from the Chlamydias differ dramatically and score between trusted and noise cutoffs. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP012334.1\|WP_083228564.1\|268903_270517_+\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	1.68329e-36
NZ_CP012334.1\|WP_083228567.1\|296267_298538_+\|exodeoxyribonuclease-V-subunit-alpha	gnl\|CDD\|236783	PRK10875, recD, exodeoxyribonuclease V subunit alpha.	0
NZ_CP012334.1\|WP_066641934.1\|300732_301620_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176109	cd08417, PBP2_Nitroaromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of dinitrotoluene and similar compounds, such as DntR, NahR, and LinR. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. Also included are related LysR-type regulators clustered together in phylogenetic trees, including NodD, ToxR, LeuO, SyrM, TdcA, and PnbR. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.33676e-61
NZ_CP012334.1\|WP_083228563.1\|266719_267622_+\|ABC-transporter-permease	gnl\|CDD\|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	6.79465e-72
NZ_CP012334.1\|WP_083228566.1\|292254_296268_+\|exodeoxyribonuclease-V-subunit-beta	gnl\|CDD\|236784	PRK10876, recB, exonuclease V subunit beta; Provisional.	0
NZ_CP012334.1\|WP_066631728.1\|275853_278082_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|377178	pfam03971, IDH, Monomeric isocitrate dehydrogenase. NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism, as it controls the carbon flux within the citric acid cycle and supplies the cell with 2-oxoglutarate EC:1.1.1.42 and NADPH for biosynthetic purposes.	0
NZ_CP012334.1\|WP_066631737.1\|285586_287449_-\|copper-resistance-system-multicopper-oxidase	gnl\|CDD\|273649	TIGR01480, unnamed_protein_product, copper-resistance protein, CopA family. This model represents the CopA copper resistance protein family. CopA is related to laccase (benzenediol:oxygen oxidoreductase) and L-ascorbate oxidase, both copper-containing enzymes. Most members have a typical TAT (twin-arginine translocation) signal sequence with an Arg-Arg pair. Twin-arginine translocation is observed for a large number of periplasmic proteins that cross the inner membrane with metal-containing cofactors already bound. The combination of copper-binding sites and TAT translocation motif suggests a mechansism of resistance by packaging and export. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds].	0

>NZ_CP012334.1|WP_066631731.1|280271_282338_-|TRAP-transporter-fused-permease-subunit
MTTAAHPEAPVVVDDEALRKAEEYIEQEEGAANRLTGPLGAFVAVVAVAMSLFHLYAAYAIVPTQILRPVHVAFVLFLCFVVFPVSPRFRHRVMAWDWALALLAIAIVVYLIMGGDDFTDRNTRPQPLDVFFGATLILLVMEAMRRTIGWILPVICICFLLYAFLGPYLPHPWTHRGYSIARLVGFMYMTLEGIFGVAVDVASSLIILFTIFGAFLQLSGAGRFYIDFSFSAMGGKPAGAGRTVVLASFLLGGPSGSGVATTVTLGTVAWPMLAKVGYARDAAGGLLAAGGLGAIISPPVMGAAAFIIAEFLKISYLDVLLMAVIPTLLFYLALFLMVEIDVRKYGMSRTVFAKVDTVWNLTRHYWFHFLSLISIVVFMLIGFSPVLSVFWAIIVAFVASFLRADTAMISYDLFRGRGPAAPLLLRSPLVEALRTGSIGMLGVGATCAGAGIIVGVVTLTGLGLKFSGIVIDYAAGSLLLTAVYTSLVVWIIGLAVPVTASYIICAVIAAPALIKLGVPDYAAHMFIFYYAVLSEVSPPTALSPFAAAAITGADPYRTTMQCWKYTVPAFLVPFIFVLAPSGQSLLLMGSAKALASESFWEIAEVTFTAAAGIFALAAGFQGWLLVKTSALQRAMFIVAGFALVYPGPVSNGLGFALVVIALGMQWRGLRRDGHAGGPGHKRDGAAAG
>NZ_CP012334.1|WP_066631730.1|278415_279618_+|cytochrome-P450
MNLQDLSSPEFYRDPYPLYEKIRARGKLFNVAPHILMTGHYDMIDAILVDRRMGKGYMESIRARYGEEGASQPIFQGLARMFLMMNPPTHTRLRALLMKAFDARRVDNLRQVCQEVADELIDAFPTSQAFDLVPAYSQPLPVRIICRLLDIPVEDADMLERDVSQLVQALEAAPLAAPALEKVNAAMRNVEDYFRRVVDARRGEPGDDLISVLLSVEEDGQGLTQDEIISNVILLFVAGHETTANMIGNALIALHQHPDQLRLLEQQPALLPRAINECMRYDSSVQFITRMALEDTEAGGIALPKGSIVFMSLGAANRDPGQFADPDRLLIERAESGNRLIAFGGGIHYCLGARLAAMELQIGLGTLLARLPGMRLVDLDALQWRKRNTVRGVEALVVTA
>NZ_CP012334.1|WP_066631728.1|275853_278082_-|NADP-dependent-isocitrate-dehydrogenase
MSTTSKIIYTLTDEAPALATYSLLPIVQAYTRSSGVAVETRDISLSGRIIAAFPDFLTDAQKISDDLTELGRLATTPEANIIKLPNISASIPQLKAAIKELQQQGYKLPDYPDEPANDKEKDVKARYDKIKGSAVNPVLREGNSDRRAPLSVKNYARKHPHKMGAWSGDSKTHVAHMDDGDFYGSEKSALIANAGTVRIELAAGGATKVLKEKTSVKAGEILDAAVLSKNKLRSFLQAQIDDAKKQDVLFSVHVKATMMKVSDPIIFGHVVSVYYKDVLAKHADTLKQIGFDANNGIGDLYAKMAALPADKRAAIEADLKAEYAQRPRLAMVNSDKGITNLHVPSDVIVDASMPAMIREGGKMWGPDGKAYDAKAVIPDRCYAGIYQAVIDDCKKNGPFDPVTMGSVPNVGLMAQAAEEYGSHDKTFEIPANGTVRVVDEAGKVLLEQPVEAGDIWRMCQTKDAPVQDWVKLAVNRARATGTPAIFWLDKNRAHDAQIIAKVERYLKDHDTNGLDLRIMAPMEACRFSLERIRAGKDTISVTGNVLRDYLTDLFPIMELGTSAKMLSIVPLMAGGGLFETGAGGSAPKHVQQFVEEGFLRWDSLGEFLALAASLEHLADVHGNAGARVLAKTLDEATGKFLDNDKSPARKVGGLDNRGSHFYLALYWAQALAAQTEDKALQAKFAGIAKTLTDNEAKIVQELGAAQGKAQDIGGYYRPNTEKTSKAMRPSATLNEALKRLGA
>NZ_CP012334.1|WP_083228565.1|272733_275712_-|autotransporter-domain-containing-protein
MSKLHKPMAPAALMAALAFVMATFAAHGASPVVIGAGKTDTTRRTISGTDSVTIQAGGTINTSGTSLTMDTSVPAPGISIVNAGTLKSGNRGIDTNGSTAGSPFNFTLTNGAGGLITTSDDSVRINGDIAVGRIVIENAGTITSASGQAIDFDKINTAGNVVINNRAGGLIQAQDADAIRPGEGGMVNNWGSIVANAPANTSGDPDNDPSNDGVDLQGHAASVHNYAGGLISGARHGITSDVNVDVINEAGGTIIGRNGSGVGSDGDGRVVNRGTITGAIDTTSVNGDGDGVDIDGKADITNYGTIQGVGAKGQKDGSPNNSEGVAAGGGTIRNLTAQSIISGQANGILIDDSAEGAAPHATTLVNEGTIRGVTGFAIKIVGTQADNVTNSGLIEGGNGLALDLGGGDDTLNLRTGSRIVGLVDGGAGNDTVNLIGSGTFAGAVNFENLTVSGGSWVLTGNQQYAHGVTVAQGGSLDVQGALGGTLTIAQGALLNGNGTLGSVQVAGTIAPGHSIGTLTLTGDYAQLAGSTYQVEVANAGQSDLIEVAGTASLAGNVTVTPMPGTQITPGLRYTILSAGQGVSGSYGSISSATQMLFLQPALSYDPNHVYVAFDRNATRYADIARTGNQRAVANGADSQPYGQFVHDTIALMNDPQDARAAFDSLSGEIHASLETSLLEDSHFARDAINNRLRAAFADGAAAPARLAGAGDATPLPAPSRSAVWGQAYGAWGDIDGNGNAAKLDRSIGGFMFGADFPVASNWRAGVAAGYDRTDLNVDGRASSADIDSYTLAAYAGTQVGGLALRLGAANTWHRIDTQRDVAFAGFTGARDKATYDGDTAQVFGEAGYALQYGTATFEPYAGIAYANLHTQRFDEDGDTGLSGRSDNTGVTYTTLGLRASQRLEAGGTTAILHGMVGWRHAFGSTTPTATQSLPAGSPFTVSGVPVAVDAAILEAGLNVQVARNVRVDLSYQGQLGDGVRQNGVAANVKVRF
>NZ_CP012334.1|WP_066631724.1|271572_272637_+|extracellular-solute-binding-protein
MNHENPRRRRFLKTAGGLALAPALPLLPALARAAGKEVIVGTWGGDYQNLLQQYISPLVAKQDIGVVFDTGNAVPRLTKLRSERNSRRGSMDVALLGEVDMYDASRSGALASIQEHQAAMPNLANVYDQFKTPYSIPHIFSAMTLVYNTQQFSSPPDSVQIMLDPKYQGRVGFSDILYLYNGLFVGAGQSGGRFSSFEPGKKFLEQLVKNKPRVYPSNEAVATAFKSGEIWLACMWKARALQWRDAGLPLGFAIPKEGTIPVTFEGAVPKNARNPDAAWAYLNALLEPEGQVHFARAMGYAPTVHNAPVPPDLQQRVGFTDEELKRIYPYDLEKLVTTKAEFLDYWTKSFKGAL
>NZ_CP012334.1|WP_066631720.1|270494_271517_+|cobalamin-biosynthesis-protein-CobW
MDRPTPVDLIVLSGFLGSGKTTLLVDFLRGPDAGDTGVIVNEVGEIGVDGAIVADGGGGVPMTLLANGCVCCSLRSGLVDTVNALLNAPRPGGRPLARIILETSGLSRPGPIIASLADPELAAHGLRLSVVTTYDCARGALGDEQFEEAAAQFAAAQRIVLTKTDLACADETAGFALATHVSRARALNPLAQIVAESDRPRAVAQAFAPLPGTSATDMALSALSAAGAAGIGGTALRHPRIHVWRGKVRQPMAWSAFSTWLDDLAGLCGDRLLRLKALLRVTDCAEPVLIQSVGTTFGMPRRMATLSPDQDVLIVITRDLDADALRELPPGSPVVLEAFA
>NZ_CP012334.1|WP_083228564.1|268903_270517_+|amidohydrolase-family-protein
MAIENPYANVDVGEESRAMNAAKGWHPPAAATARDRGDGPFKRLVLRGATIIDGTGAPPWGPVDIVVENDRIAALVLVGTPHKPIQPGRRPPPGDHEVDCHGKFVTPGFVDSHAHIGTPYHTMSGVAPPADYIYKLWLAHGVTTVREMGSMNGLGWNLDQKDKSERNDIAAPRILAHVVFPAVNDRVKTIHTPEQGREWVRKIKARGADGIKFFGAPPAIMQAALDEAAKVGLRSGCHHAQMAVTRVNALKSAQWGLTSSEHYYGLPEALFENRVVQDFPTDYNYGDEYFRFALAGQTFMQAAQPGSAKWREVMDRFLELDHTFVPTFNIYDANRDLMRARRADWHDDYTWNAIWKYFQPQRGGHGAYWYRWSTTNEIEWKQNYRLWMQFINEYKNLGGRVCAGSDSGFIFQIYGFGFVRELELLQEAGFHPLEVLRAATSLGADLLGIGDDTGSVDVGKRADLLVHDQNPLEDFKLLYGTGAMRLNDDTGKVEWKRSLRYTVKAGVVYDTEQLLADVRTLVKDSWEGDPDGPPHAR
>NZ_CP012334.1|WP_066631716.1|267652_268900_+|amidohydrolase-family-protein
MTAFLFKNANLLDPDFPELREGMHVLVEDGAIKEVSDRPIAAQSARPIDVRGRTLMPGLIDLHAHVMATQLNLSTQGMLPDALVMMRSVPIMAAMLRRGFTTVRDAGGAGWGLKCAVEEGTVVGPRLFISGRAISQTGGHGDPRPRSDHLRPMSFCGCCFRAGDIGRVADGVDEVRKAVRQELQMGADQIKIMASGGVASPTDPIASFGYSEDEIRAIVAEARGRQTYVLAHAYTAEAISRAVKCGVRTIEHGNLIDEDTAAVMASHGAYVVPTLITYEALANEGADYGLPPDSVAKIATVRTAGLHSLEIYKRAGVKMGFGSDLLGPSQRLQSDEFRLRAQVLTPHEVIQSATSVAAEVLRMDNRLGRIVPGAIADVLVVDGNPYKDVSCLLGQGDHIPLVMKDGKIFHDMMEA
>NZ_CP012334.1|WP_083228563.1|266719_267622_+|ABC-transporter-permease
MNPSASASTPASTAAARPVRLGAGLAFPASLVVLLIIMVPLLQLVRYSFNHFDPAEMMQQAFTLENYAKFFGDAYYRNVFLTTIGVAALCTVLALVLGFPVAYFLARTDSRHKSLLVILLVFPLMVGSVVRAAGWMVILGNAGIVNATLKALGLVGHSVQLMYTPTAVVVGTTAVVMPYLILTLQSVLEGMDFSVEEAARNLGADFLTTFRRIVLPIAAPGVAAGTMLVFILCMNAYATPVLLGGTGLTMMAPALYDQITRASNWPFGSAMALILVCATLLMALLSNWLIHRRYVKTMAS
>NZ_CP012334.1|WP_066631714.1|265632_266709_+|ABC-transporter-ATP-binding-protein
MAKVSLENLHKQFGASVAVADFSLEIADGELVAFLGPSGCGKTTTLRMIAGFLAPSAGTIRIGGKDVTDLPVHKRDTGMVFQRYALFPHMTVAQNVAFGLEMHKVPAAERDSRIREVLDMVRMASLRDRYPRQLSGGQQQRVAIARALAIQPKVFLLDEPLSNLDAKLRLEVREEIRALQQRLGLTTVFVTHDQEEALAVADRMAIMHDGKVQQVGTPDALYERPANLFVADFLGKMNFFQGRLAEDGVFGTEKGTRIRVEGGPPAARHMGVRPERVRLASQPGDGNALPGVVESTVYLGAQLEVRVKLESGEAILSQLANGSGRASHPGAGTHGLPAQAGGRVYACFEPADCVMFAD
>NZ_CP012334.1|WP_066631732.1|282511_283483_-|TAXI-family-TRAP-transporter-solute-binding-subunit
MKTPFVRFALLLCLVVVGSLAFTPAHAQNISIATGGTGGVYYPIGGGIAALLSKKVPGMEATAEVTGGSVDNLKLIDGDPSYIGMSMSDAAQDAYRGQDKFKGGKVPLRTLMIMYPNRMHVVTVQGKGIETMADLKGKRVSTGAPGSATEVMAFRLLEAAGLDKDKDVKRERLSVAESVNAIKDNKIDAFFWVGGLPTAAVTDLANTPGTTLKMIDNADLVPAMNKKYGNLYVEDTIPKSTYRGMDKDNKQATVMNILVANEKMPDQTAYNIVKTIFESRDELIAVHKDTADFKLENQKSAATPVPFHPGAVKYYKERGFGVD
>NZ_CP012334.1|WP_066631733.1|283874_284621_+|hypothetical-protein
MHIGSSFLPHVPAWPLIPDPARATLSDDGSVATLMASVGARVANPEPGQKAALPQHLWVENAPTASEAAYRWLEGMVDVLKEHGAYNIAIDNYRAIYPQASHRDAEKMFAIDLVRAMVDPVPARFLSSAHGSDHAPARSRAADDYRWRRVMNVLKDSGAYAAGLAHYQVYRVQRLAQACKSWTVFFKSRGMDDASIEKFLPERPRLMSWEKANSTFTGQLMRVGDPRHLSGHLNKIQHPAPRLGYRYA
>NZ_CP012334.1|WP_066631735.1|284744_285590_-|copper-resistance-protein-B
MTRARYLPRRAPRSLCRAAAVLAIVSATLQPAATARAQPAAAPAPPAGTLPTSDGTTSQPYASYGIMPHMMDDAIITHLDIEKLEFMRDRDDRDGLRWDAEFWAGTDRDKLWLKSEGDHARGDTAGRAQAYWSHAISPFWDAQLGARRDFGAGPARTWMGLGLQGTAPYGIETELTVYAGTEGRTALALKATYDLLLTQRLILAPEVEANAYGKDDARRNIGSGLSDATFSLRLRYEVTREVAPYVGVSFGRKFGDTARYAQAEGDSRSDRAILAGVRIRF
>NZ_CP012334.1|WP_066631737.1|285586_287449_-|copper-resistance-system-multicopper-oxidase
MTDAVSRSRRRFVTGLATGGLVAGTSGWAGAAMAAGQFSGQAVLSGTEFALDIAETPVNYTGTPRLATTVNGLLPGPVLRWREGDTVTLRVRNRLRVDTSIHWHGILLPSAMDGVPGLSFAGIPPGAMFTYRFPVRQTGTYWYHSHSGFQEQTGLYGALIIDPAGTDPIRADRDYTVLLSDWTDEDPMRVFHKLKAMPDYYNQNPPSLQSLARRAEREGWTPALRDRLMWQRMRMRPTDLADVSGATYTYLVNGATPAGNWTALFRPRERVRLRVINGSAMTYFDVRIPGLKLTVVSADGQPVRPVEVDEFRIGVAETYDIIVEPREDRAYTLFAQSMDRSGYARATLAPRAGMQAEVPPMDPVQPLTMMDMGMRHDMAGMDMSGDGHGGHDTQPDQAAKADAGEQMDHGMQMDDSTQMDPGMQMDRGMEKMDHGTPEEGHGGGGMIEARHPYASERGVSNAMLPEVVSTRLDDPGPGLRDNGRVVLTYADLHSIAAPGGDVDPTREIELHLTGNMDRYMWSFNGVAFTDARPIVLRHGERVRFVLVNDTMMIHPIHLHGLWSDMESPDGAFQVRKHTISLNPAQRISYRVSADTRGNWAYHCHLLYHMEAGMFRAVVVA
>NZ_CP012334.1|WP_066631739.1|287501_288425_-|LysR-family-transcriptional-regulator
MIRLDDLTLFVRAAALGSFSHAAREVDLLPGQVSAAIKRLEAELGIRLFARSTRSLRLTAEGEQYLPYAIGALDTLREGGERLQPCDTALRGTLLIAAPSDIGRNVILPWLTGFRQQHPALVLRLYLSDQVADVFRDPVDVALRYGRVGDASFVALPLAPHNRRVLVAAPDYLARHGRPQSVEDLAAHACLVYMLHGRPYDKWRFGDGDGRCTVAVSGPLLCDDGDAVHRWAVAGQGIAYKSWLDVAADVRAGRLEVILPQVPGEHAPFNLICPHRKQFSSAVRLLHAGLLAVCEPLVDGMPLTAAP
>NZ_CP012334.1|WP_083229049.1|288578_292262_+|exodeoxyribonuclease-V-subunit-gamma
MVIHSNLSESLRDVLVGWMRAHPLGPLEREVVLVQSSGIAQWLKLALAADARDGAAGGGAGIAAAFEFLLPSRFLWRAYRAVLGAAAVPEVSPFDKPRLMWRLLRLLPEVMDQPVYAPLRRFLRDDADCRKRYQLAERLADVFDQYQVYRADWLAAWAAGHDTLPRDGGADLPLPPSQRWQAALWRAVLDDVKAMAAPIGAAPSSDGRAAVHDAFLRRAADLPDDVPVPGLPRRLIVFGISTLPRQSLEVLAVLSRWTQVLMCVNNPCEHYWADIIEGKDLLRAAHARQQRRRGSPARIADDELHLHAHPLLAAWGKQGRDFIGLLDEHDNADARERLAAALGGQARRLDLFEPAGDDTLLRQLQDDIRDLRPLRETRARWSAVDTGRDASIRFHVAHSRQREVEVLHDQLLAAFDQDATLRPRDVIVMVPDIEAYAPHIQAVFGLHDGDDPRAIPYTIADRVKRHADPLLHALEQLLQLSRARFSVSEFMDLLEVPAVRDRFGIAEDQLPLLHAWIRGANIRWGLHDAQRQALGLPSSGTPAAQNSWLFGLRRMLLGYAVGGRATNWQGIEPYDDIGGLDAALLGPLVAMVESLERTWLEMSSPAAPAVWGERLAALLERFFLPGESTDAYTVQQLNTALREWLDVCAEAGLVEALPLSVVAEHWLARLDEGGLSQRFFGGAVTFATLMPMRAIPFRIVCLLGMNDGEYPRIRTPMDFDLMAYDYRPGDRSRREDDRYLFLEALLSARDRLLVSWVGRSVRDNTPRPPSVLVGQLRDHLAAGWRLAREGAADAGAPSPDADAASTVAGASGHAAAMPRPDEALLAALTTEHRLQPFSPAYFSDPSSGLFTYAREWRGGAGRVGAMQPLPPLVREEPLTLRELADFVRAPVDAFFKQRLQVSFVLEDAATEDVEPFVPDALEQWQLQDALIRAQSRALETGADFQASREAEVARIGRAGMLPDGAFGALTAEDLIAPLDDMAERYGKALARWPHAITQEFPVLVPAAGGAPALEDSLAAFRRDDDGQRCRLLVDSSSLIPKGKYRAARVVPHWVAHVAAQLAGEPVTTVVVSKAGDVVFPPLKRREAMRCMRVWMDGWQAGMSRPLPLAPAAAFEWLTRHPAPPPDDLADDDVAPAWDGPGEGGIPALLEAPAGQAARKVYEGAAEQRGEVDGSPYLQAVYPDFASLTHSGEFFALAQGWLRVMRASLYADRNKGKPTPDGQETDHA
>NZ_CP012334.1|WP_083228566.1|292254_296268_+|exodeoxyribonuclease-V-subunit-beta
MPESGRIAPPPPARQDPSATPLDVLRFPLHGSRLIEASAGTGKTFTIATLYVRLVLGHGADAGFERPLMPPQILVVTFTEAATQELRDRIRARLAEAAAYFLDDPAAVAERPPGQDTLHDLRADYPPESWAACARKLQLAVEWMDEAAVSTIHGWCNRMLREHAFDSNSLFQQTLEQNTAPLMAEVVRDYWRAHIAPLDAISAAEVRAWWPGPDELQAQLMPVLRFAPELKAPGRAGMADGLDDADIVGDAARIETTRNAVTAPDATGAAPAAGSPCDLLRATREHRLGVLGELKRPWQDWLPELRQLFDDGVAGKRVNGRQIQARYYLAWLENLRAWCEDPDARVPQLTDTAWLRLGPGLNEAWKGDPPDHPAFAALAELRQQTQALPEARHDVLRHAADWVSRRFAGEQAQRAQMSFDALLDQLDAALAGPSGATLADTLRKQFPVALIDEFQDTDPVQYRIFDAVYRVADNAGDSALILIGDPKQAIYGFRGADIYTYLRARAAVDGRLYVLGRNFRSTRPMVDAVNHCFLAAERRQEGEGAFLFRRAGGNPVPFIPVQANDRPDRLVVADAAAPALTLWWLPRPEDGKSMGAGAYVETMADACAGEIARLLTLSQQGRAGFVPRDAAAVPAAAATMPVPPRPAPSGAAGPSLGRVPLHPADIAVLVDTGRQARAVRRALSRRGVRSVYLSERQSVFASAQAGEIEFWLRACAEPDDPRALRAALATPTLGVPWQDLDRVGHDELEWEARVQQFRGYARLWREKGVLPMLRRLLDDFGVPARQLAGAEDASQAGSDGERVMTDILHIAELLQQASAQLDGEHALLRHLAEMRHAAGQGDENDALTIRLESDADLVRVITVHKSKGLEYPLVFLPYAAAFRPVRQDAVPLSWHDEQGQLKVSLVPDAAGHVRADRERLGEDLRKLYVALTRARYAAWVGVAPVANLEASALGYLIGQGLTPGEPSLPDVLETFRAGHADIALGEAPAPFDIRYRADTAAVPAGRARTMRRAVRDPWWIASYSSLRTARPGSAIEAEPETAREDVFLEAAGSDAASEAGGDAGEALARPLARAPTLAGGLEGGGLLHAFPAGAQAGTFFHELLEWAAAQGFAAIAGQPEVVRDAVARRCQVRNWSAWTDGLTAWLMDAVTRSMSLPDMPGGPVAPVALAGVGDYIAEMEFWLGADNVDVALLDRIVRAHTLDRAERPVLEPARINGMLKGFIDLVFEHQGRYYVLDYKSNRLGNDDTAYTQAAMRDAILGHRYELQYALYLFALHRLLRARLPDYDYDRHVGGAAYVFLRGTHSAQGGVFAERPPVEMMHALDRLFATAHARKEAA
>NZ_CP012334.1|WP_083228567.1|296267_298538_+|exodeoxyribonuclease-V-subunit-alpha
MFLSETDDTRGGTGGERGAQAARDAAGIHGGRIDAHAAAARRELLDLMDAWAAHAWIRPLDVVFARFLWDEVPEAPPLAILGALLASHQLAHGHACLDLGAALEDPEMTLALPPEGADLPASGVPLRSPAALLAHVSLARWQAALDVPELVGRGAGGTPLVLVERRLYLRRCWQYEQDINAGISARLARNPDLQAALPPARLRGMLDALFPAGAGAGGVAADIDWQKIACATAARSAFTIITGGPGTGKTTTVVKVLAVLQALALQGIGAADAHAAVPGVDGRTPAPDRRPLRIRLAAPTGKAAARLSESIAGAVSRLPVTDLPASEAVRQAIPTSVSTLHRLLGSRPGSRKFRHDAEHPLALDVLVVDEASMIDLETMAALLQALPPRGRLILLGDKDQLASVEAGAVLSDLCRDARAGRYTPATRDWLAQVSGERIGEDLLDSEGTALDQAIVMLRHSHRFAADSGIGRLAAAINAGNRQAVARFWRQPHAGVTRLAGRECERDFAALVLDGQARTELELAMMGGMPDAPAVDAPGDAAHDRGPHGYARYLRLMHARRPAPGAVQEDLDEWARQVLRAHGAFQLLTTLRHGLWGVDGLNRRVARLLREHGMIDATEGWYAGRPVLVTRNDYALGLMNGDIGITLALPARDGVAAVLRVAFPMTDGSGRIKWVLPSRLQAVETVFALTVHKSQGSEFDHAAVVLPERLSPILTRELLYTGITRARAFLTLLSPGGDQVLEQGIARQVRRASGLLA
>NZ_CP012334.1|WP_083229050.1|298541_300533_-|PAS-domain-containing-hybrid-sensor-histidine-kinase/response-regulator
MNDPTHPTPPTSALQALAADRRFELMLRAIKDYAIFLLDKDGYIVSWNTGAQRFKGYTAAEIIGQHFSRFYTEEDRRDGLPQRALRTAAETGLYEAEGWRVRKDGTRFWTSVVIDPVYDDHGTLIGYAKVTRDIGDKKRAQEELFAAEQRFRLLVQGVRDYAIFMLDPDGRITNWNAGAQAIKGYLAHEIIGEHFSRFYTPEDRERGEPQRAIATAMRDGRFLGEGWRLRKDGTRFWASVVIDPIRDERGNFIGFAKITRDMTERREAQLALDRSRDALNQAQKMEAIGRITGGVAHDFNNLLTIIRSSAELLRRPGLSDEKRNRYINAISDTAAKAAQLTRQLLAFARKQPLMPEVFQVTGRLRGMEQIIRTSIGSPVKLRFELPEVIRAVEADPNQFETAILNMVINARDAMPRGGQITISARQVDHIPPLRSHAGASGDFIAISVKDTGTGIEPATLRRIFEPFFTTKAVNKGTGLGLSQAYGFAKQSGGEIGVQTLMGAGSTFTLFLPCARADVAITQDAEGLVAIEASAKPLSVLLVEDNETVGRFALGLLHELGLTAHWATDGQSALSLLNARNGRFDLMFSDVVMPGMNGIELASVVRKRWPDLRVVLTSGYSHVLAEQGTHGFEFMAKPYSAESLVKMLGLEDHADSHAAGSARS
>NZ_CP012334.1|WP_066641934.1|300732_301620_-|LysR-family-transcriptional-regulator
MNLLIHFDALMTCRAISRAAEQVGVSQPAMSAALSRLRKLFNDPLLLREGNHWQPTPQALALHLEFQPLLARWQRATGPRESFDPRVTARTFSLYATDYMQFTLMPRVLPELARDAPHLHLRVMPARLQHGLSMLDTNHVELLAGYFPDPSQNLRARFLYDEPAVCIVREQHPCLRRRWNLDAYLRYPHVDLSAHTGYFSSAIDRMLQAMGRQRTVAATLSSYMVGPHVVAASDLICTVPMSVAKAAARCTRLALLDVPLKLPTLSVSLYWHERHQEDPGHGWLRQYIAERVTRP

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Crispr_ID: NZ_CP012334_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012334_5

991365-991460

Orphan

Consensus_repeat	Method
GCGCTGCGCGCGTCCCCCTCAAGGGGGCGACGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012334_5

>merge|NZ_CP012334|5|991365-991460|CRISPRCasFinder
GCGCTGCGCGCGTCCCCCTCAAGGGGGCGACGCCAGCGGACCGGAGGGAAGGCCCACCCCCACGCGCTGCGCGCTTCCCCCTCAAGGGGGCGACGC

>NZ_CP012334|5|5|991365-991460|CRISPRCasFinder
GCGCTGCGCGCGTCCCCCTCAAGGGGGCGACGC	CAGCGGACCGGAGGGAAGGCCCACCCCCAC
GCGCTGCGCGCTTCCCCCTCAAGGGGGCGACGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012334.1\|WP_066642189.1\|998427_998928_-\|YfiR-family-protein	unknown	unknown	gnl\|CDD\|379335
NZ_CP012334.1\|WP_083229069.1\|996607_997129_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|182172
NZ_CP012334.1\|WP_066632879.1\|992272_993475_+\|alpha-D-ribose-1-methylphosphonate-5-triphosphate-diphosphatase	unknown	unknown	gnl\|CDD\|237967
NZ_CP012334.1\|WP_066632881.1\|993637_996574_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012334.1\|WP_066632890.1\|1000893_1001958_+\|fructose-bisphosphate-aldolase-class-II	unknown	unknown	gnl\|CDD\|181691
NZ_CP012334.1\|WP_066632858.1\|985275_986472_-\|alpha-D-ribose-1-methylphosphonate-5-triphosphate-diphosphatase	unknown	unknown	gnl\|CDD\|237967
NZ_CP012334.1\|WP_066642181.1\|990566_991343_+\|phosphonate-C-P-lyase-system-protein-PhnK	unknown	unknown	gnl\|CDD\|183280
NZ_CP012334.1\|WP_066632883.1\|999150_999585_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012334.1\|WP_066632860.1\|987428_987893_+\|phosphonate-C-P-lyase-system-protein-PhnG	unknown	unknown	gnl\|CDD\|377702
NZ_CP012334.1\|WP_083229068.1\|983722_984253_-\|phosphonate-metabolism-protein/1,5-bisphosphokinase-(PRPP-forming)-PhnN	unknown	unknown	gnl\|CDD\|274078
NZ_CP012334.1\|WP_066632888.1\|1000304_1000634_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012334.1\|WP_066632874.1\|989646_990567_+\|alpha-D-ribose-1-methylphosphonate-5-phosphate-C-P-lyase-PhnJ	unknown	unknown	gnl\|CDD\|377586
NZ_CP012334.1\|WP_066632852.1\|982241_983183_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP012334.1\|WP_066632871.1\|988498_989650_+\|carbon-phosphorus-lyase-complex-subunit-PhnI	unknown	unknown	gnl\|CDD\|377563
NZ_CP012334.1\|WP_145925191.1\|997150_998431_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|182171
NZ_CP012334.1\|WP_066632855.1\|984282_985263_-\|DUF1045-domain-containing-protein	unknown	unknown	gnl\|CDD\|274483
NZ_CP012334.1\|WP_066642179.1\|986582_987305_-\|phosphonate-metabolism-transcriptional-regulator-PhnF	unknown	unknown	gnl\|CDD\|131378
NZ_CP012334.1\|WP_066632893.1\|1002071_1002950_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NZ_CP012334.1\|WP_066632876.1\|991555_992269_+\|phosphonate-C-P-lyase-system-protein-PhnL	unknown	unknown	gnl\|CDD\|227118
NZ_CP012334.1\|WP_066632862.1\|987894_988497_+\|phosphonate-C-P-lyase-system-protein-PhnH	unknown	unknown	gnl\|CDD\|236655

Protein	Function_ID	Function_description	E-value
NZ_CP012334.1\|WP_066642189.1\|998427_998928_-\|YfiR-family-protein	gnl\|CDD\|379335	pfam13689, DUF4154, Domain of unknown function (DUF4154). This family of proteins is found in bacteria. Proteins in this family are typically between 172 and 207 amino acids in length. Many members are annotated as valyl-tRNA synthetase but this could not be confirmed.	2.68176e-37
NZ_CP012334.1\|WP_083229069.1\|996607_997129_-\|OmpA-family-protein	gnl\|CDD\|182172	PRK09967, PRK09967, OmpA family protein.	4.19841e-47
NZ_CP012334.1\|WP_066632879.1\|992272_993475_+\|alpha-D-ribose-1-methylphosphonate-5-triphosphate-diphosphatase	gnl\|CDD\|237967	PRK15446, PRK15446, phosphonate metabolism protein PhnM; Provisional.	3.42677e-168
NZ_CP012334.1\|WP_066632890.1\|1000893_1001958_+\|fructose-bisphosphate-aldolase-class-II	gnl\|CDD\|181691	PRK09196, PRK09196, fructose-bisphosphate aldolase class II.	0
NZ_CP012334.1\|WP_066632858.1\|985275_986472_-\|alpha-D-ribose-1-methylphosphonate-5-triphosphate-diphosphatase	gnl\|CDD\|237967	PRK15446, PRK15446, phosphonate metabolism protein PhnM; Provisional.	2.2487e-142
NZ_CP012334.1\|WP_066642181.1\|990566_991343_+\|phosphonate-C-P-lyase-system-protein-PhnK	gnl\|CDD\|183280	PRK11701, phnK, phosphonate C-P lyase system protein PhnK; Provisional.	1.03774e-173
NZ_CP012334.1\|WP_066632860.1\|987428_987893_+\|phosphonate-C-P-lyase-system-protein-PhnG	gnl\|CDD\|377702	pfam06754, PhnG, Phosphonate metabolism protein PhnG. This family consists of several bacterial phosphonate metabolism protein PhnG sequences. In Escherichia coli, the phn operon encodes proteins responsible for the uptake and breakdown of phosphonates. The exact function of PhnG is unknown, however it is thought likely that along with six other proteins PhnG makes up the the C-P (carbon-phosphorus) lyase.	1.47985e-56
NZ_CP012334.1\|WP_083229068.1\|983722_984253_-\|phosphonate-metabolism-protein/1,5-bisphosphokinase-(PRPP-forming)-PhnN	gnl\|CDD\|274078	TIGR02322, Ribose_15-bisphosphate_phosphokinase_PhnN, phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN. Members of this family resemble PhnN of phosphonate utilization operons, where different such operons confer the ability to use somewhat different profiles of C-P bond-containing compounds (see ), including phosphites as well as phosphonates. PhnN in E. coli shows considerable homology to guanylate kinases (EC 2.7.4.8), and has actually been shown to act as a ribose 1,5-bisphosphokinase (PRPP forming). This suggests an analogous kinase reaction for phosphonate metabolism, converting 5-phosphoalpha-1-(methylphosphono)ribose to methylphosphono-PRPP. [Central intermediary metabolism, Phosphorus compounds].	2.98836e-58
NZ_CP012334.1\|WP_066632874.1\|989646_990567_+\|alpha-D-ribose-1-methylphosphonate-5-phosphate-C-P-lyase-PhnJ	gnl\|CDD\|377586	pfam06007, PhnJ, Phosphonate metabolism protein PhnJ. This family consists of several bacterial phosphonate metabolism (PhnJ) sequences. The exact role that PhnJ plays in phosphonate utilisation is unknown.	0
NZ_CP012334.1\|WP_066632852.1\|982241_983183_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	4.0958e-31
NZ_CP012334.1\|WP_066632871.1\|988498_989650_+\|carbon-phosphorus-lyase-complex-subunit-PhnI	gnl\|CDD\|377563	pfam05861, PhnI, Bacterial phosphonate metabolism protein (PhnI). This family consists of several Proteobacterial phosphonate metabolism protein (PhnI) sequences. Bacteria that use phosphonates as a phosphorus source must be able to break the stable carbon-phosphorus bond. In Escherichia coli phosphonates are broken down by a C-P lyase that has a broad substrate specificity. The genes for phosphonate uptake and degradation in E. coli are organized in an operon of 14 genes, named phnC to phnP. Three gene products (PhnC, PhnD and PhnE) comprise a binding protein-dependent phosphonate transporter, which also transports phosphate, phosphite, and certain phosphate esters such as phosphoserine; two gene products (PhnF and PhnO) may have a role in gene regulation; and nine gene products (PhnG, PhnH, PhnI, PhnJ, PhnK, PhnL, PhnM, PhnN, and PhnP) probably comprise a membrane-associated C-P lyase enzyme complex.	0
NZ_CP012334.1\|WP_145925191.1\|997150_998431_-\|diguanylate-cyclase	gnl\|CDD\|182171	PRK09966, PRK09966, diguanylate cyclase DgcN.	3.71845e-82
NZ_CP012334.1\|WP_066632855.1\|984282_985263_-\|DUF1045-domain-containing-protein	gnl\|CDD\|274483	TIGR03223, Phn_opern_protn, putative phosphonate metabolism protein. This family of proteins is observed in the vicinity of other caharacterized genes involved in the catabolism of phosphonates via the3 C-P lyase system (GenProp0232), its function is unknown. These proteins are members of the somewhat broader pfam06299 model "Protein of unknown function (DUF1045)" which contains proteins found in a different genomic context as well.	1.36592e-64
NZ_CP012334.1\|WP_066642179.1\|986582_987305_-\|phosphonate-metabolism-transcriptional-regulator-PhnF	gnl\|CDD\|131378	TIGR02325, Probable_transcriptional_regulator_PhnF, phosphonates metabolism transcriptional regulator PhnF. All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions].	1.53741e-76
NZ_CP012334.1\|WP_066632893.1\|1002071_1002950_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	0
NZ_CP012334.1\|WP_066632876.1\|991555_992269_+\|phosphonate-C-P-lyase-system-protein-PhnL	gnl\|CDD\|227118	COG4778, PhnL, ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism].	1.90745e-112
NZ_CP012334.1\|WP_066632862.1\|987894_988497_+\|phosphonate-C-P-lyase-system-protein-PhnH	gnl\|CDD\|236655	PRK10147, phnH, phosphonate C-P lyase system protein PhnH.	3.68092e-72

>NZ_CP012334.1|WP_066642181.1|990566_991343_+|phosphonate-C-P-lyase-system-protein-PhnK
MAPTPLLSVRGMTHTWDGIHGCRDIDFDLYPGEVLCVVGESGSGKTTLLQAVSCQVAPQAGSVRYDLRDEGLTDLATLSQARLRLLARTDWGFVRQNPRDGLRMQVSAGANIAERLMAVGERHYGGLREVAGNWLHKMEIDVGRLDDRPASFSGGMQQRLQIARNLVTHPRMVFMDEPTASLDVSVQARLLDLLRQLVSDLGLAAIVVTHDLAVARLLAHRTLVMRGGHVVESGLTDQILDDPQHPYTQLLVSSILQS
>NZ_CP012334.1|WP_066632874.1|989646_990567_+|alpha-D-ribose-1-methylphosphonate-5-phosphate-C-P-lyase-PhnJ
MTTASIPAFASATQAEVARDPHYNFAYLDESTKRMLRRALLKAVAIPGYQVPFGSREMPLPYGWGTGGIQVTAAIIGADDTLKVIDQGSDDTTNAINIRRFFARVTGVKTTESTRAATIVQTRHRIPETPLREGQIMVFQVPIPEPLRWLEPSETETRTMHSLAEYGGMHVKLYEDIAQHGHIATTYDYPVVVNDRYMMRPSPIPKFDNPKLDDNPALMLFGAGREKRVYAVPPYTRVRSLDFEDHPFTVEKWQDCCALCGSRDSYLDEIILDDQGARHFVCSDTEYCADRQSAGHRGPDAEEDAA
>NZ_CP012334.1|WP_066632871.1|988498_989650_+|carbon-phosphorus-lyase-complex-subunit-PhnI
MYVAVKGGERAILNSYRMLDSYRRGDPAVPALTLAQIREQMPLAVSRVMAEGSLYDPHLAALALKQAAGDAIEAIFLLRAYRTTLPRFGYTQPLDTARMGLQRRISATFKDVPGGQVLGPTYDYTQRLLDFSLEDDAPAAPLPPADVPLESSMPRVTDLLRHESLVEDEAVPPGDPAPFDLTRQPLAFPASRPARLQNLARADEGYLLSMGYSTQRGYGNTHPFAAEIRYGTVEVEMFVEELGFAVTLGEIDVTECQMVSQFSGNPQEGPRFTRGYGLVFGYGERKAMSMALVDRALRAAELGEAADSPANDHEYVLYHSDNVEASGFVQHLKLPHYVDFQANLELVRRMRAERDRQAGNAAQDDAPAARAAAASTLDEAIAP
>NZ_CP012334.1|WP_066632862.1|987894_988497_+|phosphonate-C-P-lyase-system-protein-PhnH
MAMTHTAATLLPGFDDPVAGAQATFRAALQALASPGQIQLLEQACGVPAGLSPAMTAMLLALADVDAPVWLPASVDDSVRGFLRFHCACPLVADPAQARFIAVPAGCIAPALDGCDAGDPAYPDLSATLLIEVQALGTGDPLTLAGPGIRGTRAVSVAGLPRGFREQWAANHALFPLGVDVFLTQGNLVCGLPRTTRMEN
>NZ_CP012334.1|WP_066632860.1|987428_987893_+|phosphonate-C-P-lyase-system-protein-PhnG
MIPDNGQPRHAPRADWMRVMALATPDALARAYAALGELPGYRKLRAPETGMAMVRARAGGTGAQFNLGEVSVTRCAVAFDDGTVGTAYIRGRAPRHAEQAAVLDGLLQMGAWHERVRKSVIEPLARAHADSAAARAAVAAQTRVDFFTMVRGDN
>NZ_CP012334.1|WP_066642179.1|986582_987305_-|phosphonate-metabolism-transcriptional-regulator-PhnF
MVERGSGIAVWRQIGEALATDIRNKRYAPGEQLPPEPELAAKFSVNRHTIRRAMGALEQGGLVRIEQGRGTFVQEHAIDYAIGKRTRFSENLGSQGVLGHTQVIASETVKSADIAHQLGLTRNAALLRVQLIGKTENRTISVAEHYFEEKRFPGFVDKLNATRSISKTYRQFGIADYTRKWSRITATLPSDDIARLLAQPKTRPILKVEALNIDQDQLPLQYSITRFSGDWVQLMVNDDD
>NZ_CP012334.1|WP_066632858.1|985275_986472_-|alpha-D-ribose-1-methylphosphonate-5-triphosphate-diphosphatase
MHPDNSPSHFLSGISGSRVLTAQGVGPACLSFEQERIADARIGAGQAHAEFDAGDLLVLPGIVDLHGDAFERAVMPRPGVTFPYDGALLDVDRQLLANGITTEFHGLTLSWEGGLRGEPYAMRMFDALDRMQRLLGARHYVHLRFETHHVAGVDVAQSWIRAGKVRFLALNDHLPSMTKRLGDDRKLLQYAERAECDLDTFQDRIRAAMESADAVAGAMRELTDCAREAGLEVASHDDRDPATRRYYHQLGCKVAEFPLTAEAAQVARSLGDAIVFGAPNVVRGGSHTNAPDATEMIRAGLCDVLASDYYYPAQLTAVMKLASRGVLPLEQAWALVSRNPARAAGLRDRGILDTGMTADAIVVDDSVPEVPRVCAAIVGGRLRYAARHFDNRLARAAA
>NZ_CP012334.1|WP_066632855.1|984282_985263_-|DUF1045-domain-containing-protein
MPQAYRYAVYLAPVGPWRELGSAWLGRDEDTGRRIPRCRTDDPRLDAWTDAPRHYGLHATLKPPFRLRPGTTAAALDEAVRALARMQAPFRIALTLRALRGFLAWCLPDDAGMHARVRALADRMVRDLDAYRAPPTPAEIARRRPDQLTLPQQRMLAEWGYPYVFDTFTFHITLTGQLGPTELDHAEELLRARAGRALDGAMPVEAVSVYVQPRPDDPFLAARHYHFDGSVRDAAGAGYMDDEASMSTPARPPEGRAPSHGEDVAQRQEGTSSDAPARPSEGRAPSHGEDVAQRQEGTSSDAPARPPEGCAPSQGDESRGDRRVQR
>NZ_CP012334.1|WP_083229068.1|983722_984253_-|phosphonate-metabolism-protein/1,5-bisphosphokinase-(PRPP-forming)-PhnN
MGASGSGKDTLLRHVRAMSTPEDRLLVAHRYITRPSGADEASVALTEEEFARREDLGCFALSWRSHGLAYGIGVEIDAWMAAGVTVLVNGSRAYLPQACARYPGLCAVEIVVDARTLKQRLTGRARESGQAITERLARAVATFDVPVGCAYVALDNNDAPEQAAKKLLEIARQRHA
>NZ_CP012334.1|WP_066632852.1|982241_983183_+|LysR-family-transcriptional-regulator
MPKQKSLQRRHIEALVAVGESRSVHRAARELGVPQPVLSRLLAEAEALIGARLFERSSHGSVPTAQGRLVLPRARFALRTMERLNDLTAGDAPPIRLGCIPRAMHTLLPHLLERVYPDGALASTDKAGTQDAAMRFEVREGNSVALFNALAAGELEFAILRGSVQDTSDEWVVERLFDERTVIYCAADHPGIPEGQVSLSRLAALGWTLPERGTTSRGAFDAFWSENGLPPIKPLMETRSFEANLALVAASRLVSIAPESIVRRHVGFGVLRIVKVRRALPINPVMLAFHRMSLEDPLLSRFHRYLVEAARMR
>NZ_CP012334.1|WP_066632876.1|991555_992269_+|phosphonate-C-P-lyase-system-protein-PhnL
MTERHIMMEARGLSKLFTLHNQGGITLPVLRDVSFDAARGECLVLSGPSGTGKSTLLRCLYGNYLATSGSIRVRDGEGWVELTRAPEQHILRLRRDVIGYVSQFLRAIPRVSTLDVVADPLRQRGVAVAQARERAAALLERLRLPRRLWDLPPATFSGGEQQRVNIARGFIGGHPLLLLDEPTASLDAGNREVVVALIRDAVAEGRCVIGIFHDDAVRDAVATRVLALEPTAAALQE
>NZ_CP012334.1|WP_066632879.1|992272_993475_+|alpha-D-ribose-1-methylphosphonate-5-triphosphate-diphosphatase
MPTTLLTHARIVLPDEVLDNASLLIEDDRIAAVDPVNARADHVVSLRGHTLMPGLIDLHCDAIEKEAEPRARVLFPLEFAVAQVDRRNAAAGITTPYHAVSFANREWGVRNNDTAAQVIRMVHAFKAHSLVDNRVHCRYEVTDELAVPVLTALMDEGMVDLLSVMDHSPGQGQFKTLDAYLEYMMGNHGMSREQAEEAARAKAQAQEGAVGRVEHLLERARRHGIPTASHDDDSVHRIAAMRALGVAMSEFPITLDTAKAAVSCGLPTILGAPNVLRGQSQSGSMRAIDAIRAGVASCLCSDYQPSTLIAAAFVAARQASLPLSQAVALVSANPAKAAGLDDRGRIQPGLRADLTAVATIGGQPLVSHTWSAGRLVFSVGYPAPLESPAPQQAQGAEVLA
>NZ_CP012334.1|WP_066632881.1|993637_996574_+|hypothetical-protein
MPGTGAGISYSRELHGSHREFCAGPFFEQYREEMRVLLDTLSEFAAQGESMDQARKITEGFNGLFRKRFNATCREGYAELIDGPGKRTLENICALLRDGTIPLHIRKSAAVNLSASLGVCEGGTLSNLIATERGLLMSAGGIKARFWKMKEDCTRGVLQEAVQEKFGQRTSYTDYEIHYVNGVWNALADEIGLEPVTDPGAPALRVQEPAFVDACRTKVLNAITPDNLAGLLAEQCLSAFRNAAPPEQHGVEYGQGMPAWFDAALDNILLDLRLGAERLTLHAFVQLDEFAERYRLRTDATLIAVALLDAIHAEGLMDDIPVQRAEWRDERGQRAVALAYGRLAWQSSRAETATAHWKSPDLLTMADLHRWREARGPGTAEMSPIEVRAAIRADDPQALRDTPAECLVDADTVLLLLARLGDDEACRYLNRHIGYFRDHFPHGERAALIDGVMHMGNVGFVLASNWYPDMYALLGEVSLTGGATRLQRWMAQRNVAAIDAVRLLAEQGWAGAAPVQRKGHLLYRLLCGKDDTPMLYDAMVADNAAGIGAWHRLVCSPAVLPSIGALLPDLLIADRKGGVAALTAAMHRDRARAVGAYHALLADPAILPKIRRRLPGLLAGTSTRFGRSLPRGSPLVYAMDGGSAAAILAYGGLLLDPAIFPEIREDMPKLFGIQRSTGRAGARAYHQSALWWAMDKGQAGAIGAYHRILARPAILECLKDSLPALVTGKDPLGRVTALYSALDKGYAPAIDAYHDLVADPVLLPFIRHVLPKSLRAEGEWGAPGLAMAMKKGYAQAVVSYHAMLADDAILPFIGRSLPGLVQARPWGEPAGVAQAVAAGHTQVVTAFHALLVDPKILSAIVHALPHLLVAKNISGAAGLPAAAREGYVGTVAAYRAILLDTRIEPYIEGRIRRRLSRATASGAMRPVPAMPKPATPAHAGSAWEAQVDQWLALHTEGRPPRPGFIARMALRVQQWAAA
>NZ_CP012334.1|WP_083229069.1|996607_997129_-|OmpA-family-protein
MRSSRTARFPAWLGACLRWALSLACAGLLLAGCQTVQKGLTPAQIAVLQEEGFKQTDEGWELGLSDKVLFDFDAYAVKPEARENIQRLTRNLLRVGLDRMRLDGHTDNVGAADYNRQLSLRRAQAVADVVTGAGVPAANVAVRGLGATRPVTDNGTTEGRAENRRVAIVIAAE
>NZ_CP012334.1|WP_145925191.1|997150_998431_-|diguanylate-cyclase
MKKNARPDSNRPTLRQALRRLHFAVTLFAVGLAGVVMTVMGVVALRAYTDHHQKLIARSIVYTVQAATVFHDRQAATETLAAIAAKEDVAAAVVFDAHNEILAEWHDSSQERFAWARQRVARLINPPPVFLPIVHQGQTVGHLRLVGRGGNLFDFLLKGLAGVVACVLVSGLVANRLSRRTSREIVRPLRTLAEVAHAVRNERAFARRVPPARIQELHALGEDFNALLDELEAWQTQWQDENASLAHKAAHDSLTGLPNRAHFEEALDRAIHDAAVLDRRVAIMFLDSDRFKEINDGMGHAAGDAVLINIAARVRGQLREGDVVARLGGDEFAIMLSPLRELSDAQRIADDILLGMRAPIRLPNGEDIVCSLSIGIAVFPDHADNAGGLFDAADSAMYHAKRRGGATQSTAGLPGRPAFQPYTAYN
>NZ_CP012334.1|WP_066642189.1|998427_998928_-|YfiR-family-protein
MVATHATAGPIPSPDDAGPRAAMVRHVVMGILSYTRWPVQPEPVRLCITGQPAYASGLFDAPARQSEPAVQPRLVAADDPALARDCDALYLGGMDDELQQQVLRRVVGHPVVSIVEDDAECAVGGMFCLDVRPGQVGFQINLDSVARSGVHIHPSVLQLSRRRLSP
>NZ_CP012334.1|WP_066632883.1|999150_999585_+|hypothetical-protein
MVQLKFSQDPEEPELWAAEKVMYSVGRPPIHVMVQTDGEMPSREFQKALLGLLDTLDDKVLDAAELLLEHYSPEECEKMGIDRARLPRDGTPQAMAQAAVLRALWLFDESCEDFELWFNVPWDHQHTYDVEFEAGEAVSCTVND
>NZ_CP012334.1|WP_066632888.1|1000304_1000634_-|hypothetical-protein
MRLRATSAFVSALMWAAAATATAQTQTTQEMQFPSHGGSLSPPSTLRMTVIPQGPAVPPPPPVRDTPESVRLYTQCRNDADREATSAEKMRIAVGQCLDQLNQRRAQGQ
>NZ_CP012334.1|WP_066632890.1|1000893_1001958_+|fructose-bisphosphate-aldolase-class-II
MALVSMRQLLDHAAENGYGIPAFNVNNLEQVQAIMEAADETNSPVIMQASAGARKYAGEGFLKYLIQAAVESYPHIPVVMHQDHGQSPKVCQGAIDLGFSSVMMDGSLKEDGKTIADYDYNVEVTRKVVDMAHKVGVTVEGELGCLGSLETMKGDKEDGHGAEGTMTREQLLTDPEQAADFVRKTQLDALAIAIGTSHGAYKFTRKPTGDILSISRIKEIHRRLPNTHLVMHGSSSVPQELLAEIREFGGDMKETYGVPVEEIQEAIKYGVRKVNIDTDIRLAMTGAIRRFFAENPSKFDPREYLKPARAAAKAICVQRYTEFGTAGNASKIKVVPLQDIARQYAGGALAQVVQ
>NZ_CP012334.1|WP_066632893.1|1002071_1002950_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MTSALHQSSIRSLPLLGRGKVRDMYAVGDDKLLIVATDRISAFDVILDDPIPGKGEVLTALTEFWLSRLGHVIPNHSTGIAPEDVVAPDEVEQVKGRAVVVKRLKPILVEAVARGYLIGSGWKDYQATGAVCGIALPSGLRQAEKLPQPIFTPAAKAEFGTHDENVDFDHVVREVGQAMAERIRDVTLALYAEASAFATTKGIIIADTKFEFGLDDNGVLHLMDEVLTPDSSRFWPADSYRVGISPPSFDKQFVRDWLETQPWDKTPPAPRLPADVIRKTAEKYREALDRLR

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Crispr_ID: NZ_CP012334_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012334_6

1101276-1101392

Orphan

Consensus_repeat	Method
CCCCGAGGGGGCCGTTTTTGTCTTGGGGCGGCCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012334_6

>merge|NZ_CP012334|6|1101276-1101392|CRISPRCasFinder
CCCCGAGGGGGCCGTTTTTGTCTTGGGGCGGCCCTGCGAGGAAAAGGGCCCCCACGCCGCGCCGGCGAGCCGGCTTGCTGCCCCCCAAGGGGGCCGTTTTTGTCTTGGGGCGGCCCT

>NZ_CP012334|6|6|1101276-1101392|CRISPRCasFinder
CCCCGAGGGGGCCGTTTTTGTCTTGGGGCGGCCCT	GCGAGGAAAAGGGCCCCCACGCCGCGCCGGCGAGCCGGCTTGCTGCC
CCCCAAGGGGGCCGTTTTTGTCTTGGGGCGGCCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012334.1\|WP_066633124.1\|1106456_1107032_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239948
NZ_CP012334.1\|WP_066633123.1\|1105704_1106460_-\|leucyl/phenylalanyl-tRNA--protein-transferase	unknown	unknown	gnl\|CDD\|234720
NZ_CP012334.1\|WP_066633126.1\|1107042_1107711_-\|DUF2946-family-protein	unknown	unknown	gnl\|CDD\|378577
NZ_CP012334.1\|WP_066633101.1\|1093884_1094097_-\|zinc-finger-domain-containing-protein	unknown	unknown	gnl\|CDD\|226826
NZ_CP012334.1\|WP_066633116.1\|1102878_1103463_+\|TIGR01841-family-phasin	unknown	unknown	gnl\|CDD\|130900
NZ_CP012334.1\|WP_145925196.1\|1108831_1109242_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012334.1\|WP_066633106.1\|1096017_1096359_+\|AzlD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377512
NZ_CP012334.1\|WP_066633121.1\|1104900_1105644_-\|arginyltransferase	unknown	unknown	gnl\|CDD\|234939
NZ_CP012334.1\|WP_066633117.1\|1103659_1104709_-\|quinone-dependent-dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235388
NZ_CP012334.1\|WP_066633134.1\|1107793_1108723_-\|aldose-1-epimerase	unknown	unknown	gnl\|CDD\|185698
NZ_CP012334.1\|WP_066633115.1\|1101483_1102461_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein-BugD	unknown	unknown	gnl\|CDD\|270294
NZ_CP012334.1\|WP_066633109.1\|1098152_1098533_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP012334.1\|WP_066633103.1\|1094216_1095137_-\|branched-chain-amino-acid-transaminase	unknown	unknown	gnl\|CDD\|235841
NZ_CP012334.1\|WP_066642226.1\|1109265_1110171_-\|proline-dioxygenase	unknown	unknown	gnl\|CDD\|177683
NZ_CP012334.1\|WP_066633099.1\|1093397_1093820_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379209
NZ_CP012334.1\|WP_066642224.1\|1098592_1099396_+\|EI24-domain-containing-protein	unknown	unknown	gnl\|CDD\|377798
NZ_CP012334.1\|WP_066642219.1\|1096749_1098120_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|236722
NZ_CP012334.1\|WP_066642220.1\|1099414_1100224_+\|competence/damage-inducible-protein-A	unknown	unknown	gnl\|CDD\|223986
NZ_CP012334.1\|WP_066633112.1\|1100372_1101254_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP012334.1\|WP_083228626.1\|1095343_1096021_+\|AzlC-family-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224215

Protein	Function_ID	Function_description	E-value
NZ_CP012334.1\|WP_066633124.1\|1106456_1107032_-\|NUDIX-hydrolase	gnl\|CDD\|239948	cd04511, Nudix_Hydrolase_4, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, U=I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	4.69541e-75
NZ_CP012334.1\|WP_066633123.1\|1105704_1106460_-\|leucyl/phenylalanyl-tRNA--protein-transferase	gnl\|CDD\|234720	PRK00301, aat, leucyl/phenylalanyl-tRNA--protein transferase; Reviewed.	2.64976e-124
NZ_CP012334.1\|WP_066633126.1\|1107042_1107711_-\|DUF2946-family-protein	gnl\|CDD\|378577	pfam11161, DUF2944, Protein of unknown function (DUF2946). This family of proteins with unknown function appear to be restricted to Proteobacteria.	8.56617e-68
NZ_CP012334.1\|WP_066633101.1\|1093884_1094097_-\|zinc-finger-domain-containing-protein	gnl\|CDD\|226826	COG4391, COG4391, Uncharacterized protein conserved in bacteria [Function unknown].	1.27713e-12
NZ_CP012334.1\|WP_066633116.1\|1102878_1103463_+\|TIGR01841-family-phasin	gnl\|CDD\|130900	TIGR01841, hypothetical_protein, phasin family protein. This model describes a family of small proteins found associated with inclusions in bacterial cells. Most associate with polyhydroxyalkanoate (PHA) inclusions, the most common of which consist of polyhydroxybutyrate (PHB). These are designated granule-associate proteins or phasins; the member from Rhodospirillum rubrum is an activator of polyhydroxybutyrate (PHB) degradation. However, the member from Magnetospirillum sp. AMB-1 is called a magnetic particle membrane-specific GTPase.	1.12291e-11
NZ_CP012334.1\|WP_066633106.1\|1096017_1096359_+\|AzlD-domain-containing-protein	gnl\|CDD\|377512	pfam05437, AzlD, Branched-chain amino acid transport protein (AzlD). This family consists of a number of bacterial and archaeal branched-chain amino acid transport proteins. AzlD is known to be involved in conferring resistance to 4-azaleucine although its exact role is uncertain.	2.69074e-12
NZ_CP012334.1\|WP_066633121.1\|1104900_1105644_-\|arginyltransferase	gnl\|CDD\|234939	PRK01305, PRK01305, arginyl-tRNA-protein transferase; Provisional.	1.25681e-140
NZ_CP012334.1\|WP_066633117.1\|1103659_1104709_-\|quinone-dependent-dihydroorotate-dehydrogenase	gnl\|CDD\|235388	PRK05286, PRK05286, quinone-dependent dihydroorotate dehydrogenase.	0
NZ_CP012334.1\|WP_066633134.1\|1107793_1108723_-\|aldose-1-epimerase	gnl\|CDD\|185698	cd09021, Aldose_epim_Ec_YphB, aldose 1-epimerase, similar to Escherichia coli YphB. Proteins similar to Escherichia coli YphB are uncharacterized members of the aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism, catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen.	4.85104e-89
NZ_CP012334.1\|WP_066633115.1\|1101483_1102461_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein-BugD	gnl\|CDD\|270294	cd13576, PBP2_BugD_Asp, Aspartic acid transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	8.95054e-148
NZ_CP012334.1\|WP_066633109.1\|1098152_1098533_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	5.33598e-14
NZ_CP012334.1\|WP_066633103.1\|1094216_1095137_-\|branched-chain-amino-acid-transaminase	gnl\|CDD\|235841	PRK06606, PRK06606, branched-chain amino acid transaminase.	0
NZ_CP012334.1\|WP_066642226.1\|1109265_1110171_-\|proline-dioxygenase	gnl\|CDD\|177683	PLN00052, PLN00052, prolyl 4-hydroxylase; Provisional.	2.64537e-39
NZ_CP012334.1\|WP_066633099.1\|1093397_1093820_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379209	pfam13474, SnoaL_3, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	5.86126e-17
NZ_CP012334.1\|WP_066642224.1\|1098592_1099396_+\|EI24-domain-containing-protein	gnl\|CDD\|377798	pfam07264, EI24, Etoposide-induced protein 2.4 (EI24). This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53. It has been suggested to play an important role in negative cell growth control.	2.62781e-10
NZ_CP012334.1\|WP_066642219.1\|1096749_1098120_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|236722	PRK10590, PRK10590, ATP-dependent RNA helicase RhlE; Provisional.	2.54917e-156
NZ_CP012334.1\|WP_066642220.1\|1099414_1100224_+\|competence/damage-inducible-protein-A	gnl\|CDD\|223986	COG1058, CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only].	7.6305e-66
NZ_CP012334.1\|WP_066633112.1\|1100372_1101254_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	4.50669e-77
NZ_CP012334.1\|WP_083228626.1\|1095343_1096021_+\|AzlC-family-ABC-transporter-permease	gnl\|CDD\|224215	COG1296, AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism].	9.14346e-29

>NZ_CP012334.1|WP_066633112.1|1100372_1101254_+|IclR-family-transcriptional-regulator
MTRPSAPASTPQSPGDGHATIAIQVIERAMRLLDALAAQPEPVTLKELAATTGLHASTAHRILNDLVVGRYVERVDNGVYQLGMRLLELGSLVKGRLNVRDAAKGPMHDLHELTGQTVNLSVQQGDEIVYIDRAWSERSGMQVVRAIGGRAPLHLTSTGKLFLSMAEPRQVRAYALRTGLAGHTGNSLTRLDLLERELAKVRSHGYARDNEELEVGVRCIAAGIHDDSGKLVAGLSISAPTERMQDEWIARLKDTAARISASLGYDVRVAETDFDPLEVDGHPATQRDGAQAA
>NZ_CP012334.1|WP_066642220.1|1099414_1100224_+|competence/damage-inducible-protein-A
MSLDSTTPRIGLIIVGDEILSGRRQDKHFSKVVELLSARGLRLAWAEILPDDRDTLVAAYRRSFAGGDIVFSCGGIGATPDDHTRQAAAEALDLPLALHPDAEREITLRCAEMAAKGQGSADMRTPENQRRLEMGRFPQGCEVVPNPYNRIPGFFIRDHTFVPGFPVMAWPMLEWTLDTRYRDLHHRTAHAEHAFLVYGLPESRIAPVMEEIQARWPGVKAFSLPSVGEDGRSPHIDLGVKGEPAAAAEAMNHLRAEVERLGGRLTPPA
>NZ_CP012334.1|WP_066642224.1|1098592_1099396_+|EI24-domain-containing-protein
MPASSYSPSNPPPVSAGLAGVWQAFKRATVSQCHPAMLFAVLLPFLIALVGAILLLWFCWTPLTDWLRDEASRWSVVNNVDEWLVAVGLFSLKVYLVPIVAVAILLPISGILGLAIAAIFVMPLVLRHVSEREYAAVSKQGKFGTAVSVWNALWVSIAFAVGWLLTLPLWLVPPMAVLLSIFWWAFAFSRMMRIDAIVEHASPEERRVLLRRHNLGFWIVGLVCSLINLLPPAWVFLPVFSALVFAHYGLDALQRLRQEKAIEMAGR
>NZ_CP012334.1|WP_066633109.1|1098152_1098533_-|thioredoxin-family-protein
MSVLEPGNDTAALRGLLQRPDIDLVACFCAAWCDTCREYRPKLETLASRTAATAFAWIDIEDHPDLLGEEEVENFPTLLVQRAGKTVFYGPMLPHIGHLERLLASLGPDSAVVATRLPDVRGLLAG
>NZ_CP012334.1|WP_066642219.1|1096749_1098120_+|DEAD/DEAH-box-helicase
MVASITETGYTTPTPIQAQAIPVVIAGRDVMGAAQTGTGKTAAFTLPILHRLMPMANSSASPARHPVRALILTPTRELADQVAESVKRYSKRTPLRSAVVFGGVDIGPQKESLRNGCEVLVATPGRLLDHVEQKNVNLGQVGILVLDEADRMLDMGFLPDLERIIRLLPEQRQNLLFSATFSNEIRKLARSYLSHPAELEVAARNATADTVTQIAYEMSSEGKRAAVVHLVKSRNLNQVIVFSNTKIGTARLARELERDGIKAESIHGDKSQADRMKALDAFKAGQLEVLVATDVAARGLDVAGVPCVINYDLPYNAEDYVHRIGRTGRAGASGEAIALFTPSEERLLLDIEKLIKRPVPRGKLDVPAELIARSRGHRDESRGSHDRREPRVRSSGDRRYGDSGTRQAPVDDFFLKPYVPSNPAPESTSGEDAPGERGAAPKRKVAVLLGGTRKPS
>NZ_CP012334.1|WP_066633106.1|1096017_1096359_+|AzlD-domain-containing-protein
MTLDMAAEDAYVYAAIALLMLCSVITRAGYQLFGDYLPLSDSVRRALRYAPAAALTAIIVPDLLPWKAGVGPLLDMKLLAGVVGVLVFLRTRSAVLVIVAGMLVLWGLRWLAP
>NZ_CP012334.1|WP_083228626.1|1095343_1096021_+|AzlC-family-ABC-transporter-permease
MEGLRAVAPTLVATAAWGLVTGIAMVKSGLAESMALLMTLTLYAGSAQLTSLPLIASGAPLWLIFAAGFVVNLRFLIFGAALHPYFRHLSWSRRLALGYFTTDMGFVLFIPRYGDARVRGTREQLWFFVGVITPGWFVWQGSSIAGIYLGSLVPAAWSLDFAAVLALLAIVVPLATTRPMLAAMAAAAITAWVGQIFPLRLGLAAAVVAGVVAGMLAERHARSRA
>NZ_CP012334.1|WP_066633103.1|1094216_1095137_-|branched-chain-amino-acid-transaminase
MSMADRDGFIWYDGKLVPWRDATTHVLTHSLHYGLSVFEGVRAYKTDGGTAIFRLKDHTKRLFNSAHIYQIPIPYDAETLEAAQCEVVRANQLESCYLRPLVFYGSEKMGVSPKGAKVHVAIAAWPWGAYLGEQALAEGIRVKVSSYARQHVNVTMPRAKVATTYANSIIANSEALQDGYDEALLLDTEGFVAEGAGENIFIVKDGVLVEPEIASALTGITRSTIHALAADLGIPLLTRRLTRDDVYIADEAFFTGTAAEVTPIREVDNRRIGAGRRGPVTERLQQAFFDLVQGRNAKYQAWLTKV
>NZ_CP012334.1|WP_066633101.1|1093884_1094097_-|zinc-finger-domain-containing-protein
MTAAATASKHEVIEVGAEDLPVYCPGPKAPLWSMHPRVFLDVAHTGSTRCPYCGAEYRLKPGTVLGSHGH
>NZ_CP012334.1|WP_066633099.1|1093397_1093820_-|nuclear-transport-factor-2-family-protein
MFATPQETEDAFYEALEHADLARLMQVWADDEEVVCIHPGGLRIVGLKAVEESWQTILAAGPLHIRPMQPVVMQSIASAVHILVEHVGSTRGPHDSYVSCYATNVYHKGATGWRMVMHHASAAPAEAGLLDLHDIPGMLH
>NZ_CP012334.1|WP_066633115.1|1101483_1102461_-|tripartite-tricarboxylate-transporter-substrate-binding-protein-BugD
MPFPSRRLAAALAAVTLSAAGAAHAAYPDHVINMVVPFAAGGPTDNVARSLAEAMRPSLGQSIIVENKGGAGGTIGTTFAARAPADGYTVLLMHVGFSTAPSLYKDSGYDPFKSFEPIGLVVDVPMTILARENFPPNNIKELAEYVKKNADKITLANAGIGAASHLCSTMLNEAFGVQLLTVPYKGTAPAMNDLLGKQVDMLCDQTTNTTQQINAKKVKAYAVTSLKRVATLPDLPTMDESGYKGFQVGIWHGMWVPKGTPKPVVDKLVKALQAGVNDPKFQERMNTLGASVLADEANPQALETLVKQQVPQWAELFKKAKIEKQ
>NZ_CP012334.1|WP_066633116.1|1102878_1103463_+|TIGR01841-family-phasin
MSAIPQQVFARQKAGINTLIATQSALFAGFEKLVDLNLKVIKATIDEVALRSQQAADVKDPQEALAFSTGLVQPSAEKALAYGKHVYDIVAGVQGELVKLGEEHIAENQAQLSEAIDQLAKNAPTGTEGAVALIKSSLATATSAYDSMSKAAKQAAEVAESNLNAAANATFKAASDAADVANKVATPRSRRAAA
>NZ_CP012334.1|WP_066633117.1|1103659_1104709_-|quinone-dependent-dihydroorotate-dehydrogenase
MSILFHAYPLARRALFAMDAETAHEVTLKSLQRAYECGLTRSLMHAAPLAPITLMGLRVPNAVGLAAGLDKNGAYIDALGNLGFGFVEVGTVTPRPQPGNPKPRLFRLPSANALINRLGFNNLGLDAFIANVKRSQWRAQGGILGLNIGKNADTPIAQAADDYLLGLRGVFPHADYVTVNISSPNTQNLRSLQGGDELSDLLGRLREARKALADTHGRDVPLAVKIAPDLTPEQVDGIADILPRYGVDGVIASNTTLSRAAVAGLPHAEEAGGLSGPPVHELCLAVIARLKQRLGSSLSIIGVGGIHSGRQAAEKMAAGADAVQLYTGLIYRGPALVRECVDATAVRAR
>NZ_CP012334.1|WP_066633121.1|1104900_1105644_-|arginyltransferase
MSQLKELPFSTLQFYATAPYPCSYLPGRQARSQVAAPGHLIHAGTYSHLVEQGFRRSGLFTYRPHCDGCQACIPVRVDAARFAPNRSQRRAWKRHGDLRAFVAELAWSPEHYELYTRYQQGRHPGGGMDEDSRTQYAQFLLTSRVNTRLVEFRTPEGSLAMVSIIDVLDEGLSSVYTFYDPDLAGSLGTYSILWQIEQCRALDLPWLYLGYWISASRKMAYKAGFRPAQLLIDGTWRDSPAQEDAAG
>NZ_CP012334.1|WP_066633123.1|1105704_1106460_-|leucyl/phenylalanyl-tRNA--protein-transferase
MKLPWVDPDTPLPPVEFAMREPDGLLAAGGDLSVERLTEAYTRGIFPWYSEGEPVLWWSPDPRMVLACEDFIVSHSMAKLLRRLAREEQHAQPHVQVRVDTAFDQVLQACAAPRDGLSGTWITDEMRETYAAWHRAGAAHSVETWVDGKLRAGLYGISLGGMFYGESMFTQVSDGSKIALAHLVRFLANHDVPWIDCQQQTRHLASLGARPLPRAQFVARVAELVTRPAPPWRCGRLDTQGRLLPLPEATP
>NZ_CP012334.1|WP_066633124.1|1106456_1107032_-|NUDIX-hydrolase
MSEKPPHYFPAPRRARFCSQCGSPVDRRVPDGDNRERDICDHCGAIHYQNPRVVVGTVPVWENRILLCRRAIEPRYDTWTLPAGFMELGETTAQGAARETLEESGARIELGDLFTVIDVPQVDQVHVYYLARALGPELDPGPESLDARYYDESEIPWDDLSFRTVVTTLRHFLEDRRRGVFGAHRYSLEHH
>NZ_CP012334.1|WP_066633126.1|1107042_1107711_-|DUF2946-family-protein
MDASVLKSIARWPNIPAVAGWLSLDAAGRWRLHPDGDAAQGGPGVSIGNPAILAFMGRNYDHDEQGRWFFQNGPQRVYVRLDAAPYILRTSADATCLETHTGLPVQDVTAWYLDESHRLYASTDLGPGMIAGRDVSALMDAMRLEDGSDALEAAAGLPEDGGALRVHHPASKQGAPLRRLRHDAIERELGFVANPRTSSSDPQGPGSGSAAPHAAPTGQPSR
>NZ_CP012334.1|WP_066633134.1|1107793_1108723_-|aldose-1-epimerase
MNETTILRLEHGDASVEISPGLGGTILRHTWRGVPILRPSDGVPDIARLSACYPLLPFSNRLAGGRLDFGGRVYPIPQTVDYAPLPMHGLAWQRPWRVESHTACSAVLAQDYAPQGATPPWPFPYAAQQSFTLDDAGLRMTLSIRNTGTVAQPAGLGWHPYFPRTPRTRVYADTGDMWVNDEAHLPMRLVPAPAALASGMLAEHADYDNVFRGFRGHAAVAWPERDTAVTLRADPIFSHLVIFTPPGKPHLAVEPVSHMTDAFNRYTAAGGTAIPGHDPDTGTTVLAPGATLTGAICLRPSTLREAGIP
>NZ_CP012334.1|WP_145925196.1|1108831_1109242_+|hypothetical-protein
MKKPRMHPVARALLYIAAAVALTIAPWAASRVQAADQRSSSGSSRPLMPGNQPAGTGLNQPVPGSDLGTNPQRPTTPATTPGPVTPPTSVSPGGDAPSSMPGQGTVKGSKGAPASVGDPAGGTAGSRGAKDSRYGR
>NZ_CP012334.1|WP_066642226.1|1109265_1110171_-|proline-dioxygenase
MALTVRFSNQVRDWIAQNLGRGVAAQDIVDELIVHRTAPDLAGAMVAAVANALTHDAPLPDGELVLEAGVDLAPGAPAYRADAMRLAPGPVIRAGDRDVRVLARMARPGTAILADMLDAGECDRLIAAARPRLRPSLVVDPITGLDVARDHRSSLGMFFRPRETDLIEKIEQRIARLIDRPIENGEGLQILHYPAGAESTPHFDYLMPTNEANRESLARSGQRVCTLIMYLNDVPAGGETTFPESGWSILPRKGHAVYFEYANAAGQTDPASLHAGAPVLAGEKWIATKWVRTRRFVPRAG

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Crispr_ID: NZ_CP012334_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012334_7

2311425-2311511

Orphan

Consensus_repeat	Method
GCGCGAAGCGCTTCGGGGGTGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012334_7

>merge|NZ_CP012334|7|2311425-2311511|CRISPRCasFinder
GCGCGAAGCGCTTCGGGGGTGGGTCTTTCCCCCGGTCCGCCGGCGTCGTCCCCTTGAGGGGGAAGCGCGTAGCGCTTCGGGGGTGGG

>NZ_CP012334|7|7|2311425-2311511|CRISPRCasFinder
GCGCGAAGCGCTTCGGGGGTGGG	TCTTTCCCCCGGTCCGCCGGCGTCGTCCCCTTGAGGGGGAA
GCGCGTAGCGCTTCGGGGGTGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012334.1\|WP_066635238.1\|2311519_2312368_-\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD	unknown	unknown	gnl\|CDD\|184559
NZ_CP012334.1\|WP_066635234.1\|2307999_2308254_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NZ_CP012334.1\|WP_066635258.1\|2321401_2322175_-\|cephalosporin-hydroxylase	unknown	unknown	gnl\|CDD\|368223
NZ_CP012334.1\|WP_066635255.1\|2319426_2321238_+\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|180579
NZ_CP012334.1\|WP_066635261.1\|2323220_2324048_-\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223528
NZ_CP012334.1\|WP_083228764.1\|2308366_2309083_-\|SCO-family-protein	unknown	unknown	gnl\|CDD\|239266
NZ_CP012334.1\|WP_066635246.1\|2315001_2317710_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	unknown	unknown	gnl\|CDD\|236500
NZ_CP012334.1\|WP_066635214.1\|2296405_2298778_-\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NZ_CP012334.1\|WP_066635228.1\|2304400_2306446_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012334.1\|WP_066635231.1\|2306804_2307653_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012334.1\|WP_066635236.1\|2309132_2311196_-\|M3-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341051
NZ_CP012334.1\|WP_066635226.1\|2301753_2303829_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012334.1\|WP_066642702.1\|2322167_2323217_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|372616
NZ_CP012334.1\|WP_066635243.1\|2312364_2312991_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|226932
NZ_CP012334.1\|WP_066635223.1\|2300235_2301654_+\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|235774
NZ_CP012334.1\|WP_066635220.1\|2299443_2300172_+\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|223750
NZ_CP012334.1\|WP_066635265.1\|2324044_2325268_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|378005
NZ_CP012334.1\|WP_066635245.1\|2312987_2314742_-\|PAS-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226654
NZ_CP012334.1\|WP_066642690.1\|2299112_2299313_+\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328
NZ_CP012334.1\|WP_066635252.1\|2317722_2319414_+\|dihydrolipoyllysine-residue-acetyltransferase	unknown	unknown	gnl\|CDD\|237000

Protein	Function_ID	Function_description	E-value
NZ_CP012334.1\|WP_066635238.1\|2311519_2312368_-\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD	gnl\|CDD\|184559	PRK14189, PRK14189, bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase.	0
NZ_CP012334.1\|WP_066635234.1\|2307999_2308254_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	1.53832e-11
NZ_CP012334.1\|WP_066635258.1\|2321401_2322175_-\|cephalosporin-hydroxylase	gnl\|CDD\|368223	pfam04989, CmcI, Cephalosporin hydroxylase. Members of this family are about 220 amino acids long. The CmcI protein is presumed to represent the cephalosporin-7--hydroxylase. However this has not been experimentally verified.	5.34413e-120
NZ_CP012334.1\|WP_066635255.1\|2319426_2321238_+\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|180579	PRK06467, PRK06467, dihydrolipoamide dehydrogenase; Reviewed.	0
NZ_CP012334.1\|WP_066635261.1\|2323220_2324048_-\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	3.90794e-28
NZ_CP012334.1\|WP_083228764.1\|2308366_2309083_-\|SCO-family-protein	gnl\|CDD\|239266	cd02968, SCO, SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c oxidase (COX). They contain a metal binding motif, typically CXXXC, which is located in a flexible loop. COX, the terminal enzyme in the respiratory chain, is imbedded in the inner mitochondrial membrane of all eukaryotes and in the plasma membrane of some prokaryotes. It is composed of two subunits, COX I and COX II. It has been proposed that Sco1 specifically delivers copper to the CuA site, a dinuclear copper center, of the COX II subunit. Mutations in human Sco1 and Sco2 cause fatal infantile hepatoencephalomyopathy and cardioencephalomyopathy, respectively. Both disorders are associated with severe COX deficiency in affected tissues. More recently, it has been argued that the redox sensitivity of the copper binding properties of Sco1 implies that it participates in signaling events rather than functioning as a chaperone that transfers copper to COX II.	2.7198e-51
NZ_CP012334.1\|WP_066635246.1\|2315001_2317710_+\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	gnl\|CDD\|236500	PRK09405, aceE, pyruvate dehydrogenase subunit E1; Reviewed.	0
NZ_CP012334.1\|WP_066635214.1\|2296405_2298778_-\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP012334.1\|WP_066635245.1\|2312987_2314742_-\|PAS-domain-containing-sensor-histidine-kinase	gnl\|CDD\|226654	COG4191, COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms].	1.93498e-46
NZ_CP012334.1\|WP_066642702.1\|2322167_2323217_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.17164e-19
NZ_CP012334.1\|WP_066635243.1\|2312364_2312991_-\|response-regulator-transcription-factor	gnl\|CDD\|226932	COG4566, TtrR, Response regulator [Signal transduction mechanisms].	3.9105e-91
NZ_CP012334.1\|WP_066635223.1\|2300235_2301654_+\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|235774	PRK06292, PRK06292, dihydrolipoamide dehydrogenase; Validated.	0
NZ_CP012334.1\|WP_066635220.1\|2299443_2300172_+\|glutathione-peroxidase	gnl\|CDD\|223750	COG0678, AHP1, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	7.99937e-89
NZ_CP012334.1\|WP_066635265.1\|2324044_2325268_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|378005	pfam08484, Methyltransf_14, C-methyltransferase C-terminal domain. This domain is found in bacterial C-methyltransferase proteins. This domain is found C-terminal to methyltransferase domains such as pfam08241 or pfam08242. But this domain is not a methyltransferase.	1.25169e-87
NZ_CP012334.1\|WP_066635236.1\|2309132_2311196_-\|M3-family-metallopeptidase	gnl\|CDD\|341051	cd06456, M3A_DCP, Peptidase family M3, dipeptidyl carboxypeptidase (DCP). Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.	0
NZ_CP012334.1\|WP_066642690.1\|2299112_2299313_+\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	2.13598e-10
NZ_CP012334.1\|WP_066635252.1\|2317722_2319414_+\|dihydrolipoyllysine-residue-acetyltransferase	gnl\|CDD\|237000	PRK11855, PRK11855, dihydrolipoamide acetyltransferase; Reviewed.	0

>NZ_CP012334.1|WP_066635236.1|2309132_2311196_-|M3-family-metallopeptidase
MSANPLLAPVEDLVDYAAIKPEHIVPAMDSLLDTARQAVDRAADPALPATWEAVIEPLDSTSERLWRAWSVAGHLNAVVNTPELREAYNAALPKVTDFSTWVGLHEGLYKQYQRLHAAPGFASWSPVRQRVIDLALRDFRLSGVELQGADRDRYAEISDREAQTSQKFSENVLDAIDAWSLLIEDEARLDGVPDDVKQAARQAAEADGKPGWKLTLKMPCYLPVMQYARDRALRETLYRAYGTVASEQGEGKFDNSPLIEELLSLRAEESRLLGFRNFAELRLQTRMARSADQVVAFLRDLAGRARPYAERDLAQLRDYARQELGMDDLQPWDVPYASERLREARYAYSEDDIKQYFTEPRVLAGLFEVIETLFTVRLREFPVSAWHPDVRGVRVERPDGELVGYLYLDLYARAGKQGGAWVDSERSRRLAGGTLHTPVAYLTCNFSRPNGGKAALLTHDDVITLFHETGHALHALLSEVDEPGAAAFASVEWDAIELPSQFMENFCWEWPVVQRLSAHVDTGEPLPRALFEKLQAARNFQSGMQTVRQIEFALFDMLLHERPEGASIRSVLDLLGEVRREVAVLTPPDWHRMPHSFSHLFAGGYGAGYYSYKWAEVLSADAYEAFEEAARGGQHGTLDAATGARFRREILAVGGARPAADSFKAFRGREPRIDALLRHSGMTALQD
>NZ_CP012334.1|WP_083228764.1|2308366_2309083_-|SCO-family-protein
MPVPARRLAAAAGSAAPHLAAFGAGAVHAGLAIPALARAILYRLAAAVVALLMMTAAAQAAPQPAVYDIRGHLPELKFTLSGAQGRTVTQDEVKGKTVLLFFGYASCPDVCPTTMAQLADVMNRLGKEGADVRILFVSVDPHRDTPDGLQAYVNAFNPNAIGLTGTERQIADVARRYRVSYQIDKPKPGADPKVYNVTHSRGVYVFDSHGDARLLLSDSSSTDEIVDALRKLVGSVQR
>NZ_CP012334.1|WP_066635234.1|2307999_2308254_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MDIIIMIIVGFIVGLIARALMPGEQSMGIILTSILGIVGAVVAGFLGRTLGWYAPGEPAGWIASVIGAIIVLFVVGLFTRRRGA
>NZ_CP012334.1|WP_066635231.1|2306804_2307653_-|hypothetical-protein
MSVSTLCNIPITASYTIPATLAPHDADSSLAFTSTATSPARASRARAHTAGPPRPSSAAPGARLTHANNTRTVLRHAPLRPVRGHIVDAPAYMRPRPSRHDDALVSMPTSLHHGITPASTRAARAGSVATLRRDSIASVSSIGSMHSTASRGMAGHSSIGSMRSIASLSSIGSALSIASQSSIGSIAGESGIGSIRGVDVDHRPASVSSRESGLSCAGSVDSGLGGARHRQVSEATITITDDTPRVIVSEHVLTQPADCPAPGLTWQRKWLTPARSNKTRPD
>NZ_CP012334.1|WP_066635228.1|2304400_2306446_-|hypothetical-protein
MRTRILRLADARNGTVLRHAPLRPGAHQGEGTPLSRPLPAHQNWHSSQASIMIGDSTPEAVMPDRRTPSPAVSEVTLAITDHAAETTWLMESTDPRPCLPRAPAVCAAVDALLADCLPGPTMPSIRPPGVFPSPAQEPSPQETSLYLLGCHIRGELFDQASGWHERAASRIATAAAAMTSGIAQQAIAVDFTQLALALHISLQSEADGAREPATGDTGGPRTVTAADLDILDRVARLRDVDNVDRRKLEAAVDTALVPWTNTTARRVAGRVVDVVAAMAHEVFHRRVYRDEIEKLVAASDRDDHDAMHEAFIRLYHMDRAFASPHQSGVDRCIRLVKSLPAPVQADFMRTFLPRSEHPADDVPAQGLQAYLRPVQAGVVLGSQVSDRLRVDLQRMMADLLAAAAHLRGEEAAIAPAADAGRKRTTTDLFDMPAPQRPTLAAMVRNIWRRLGPATPLERAERRLFQAIKQQAVLPIRPIRAQWTSMDAAIRDVLALQQPPASYADVVQACVRTLTPEQCVALHHIVDSYEHLKEDDPALHRSLSAERKQHLAALDAALTKEVDVRPAMPAVDKAIRALARGSRGRDLLGALEALSACLDKHAGDLPAARTLCAATLKRLALPPGDLDAALARLRTLAAQARLKDDITATFETYRRTPNAVAETSSLMPSLRVLAAALEAQAA
>NZ_CP012334.1|WP_066635226.1|2301753_2303829_-|hypothetical-protein
MENLAHSTPRSHSPASSGYSSKDSIPASIPASSGYHSNGSISTSIPSSRDSLYDANRHAMARWQTSEAGIVIGGHGLEHAGPDIPATPPVISEVKATITDSPFITLTKVRPVEPAPALVRAPLVRIAVNALLADCTGPEGGNRAGAALAESAAPRSEGSELYLLGCRVQQAMVDETLAWHERAAAELAAAAARLTSGTAEITIESNFVQMALASAIDDYATRNGPCRASSDKELLPSPILARSDILNRLRQLRDLDGANRRKLDVAVDRALGPAASPQTRCVARLIIDLVAEMANESFRRRVYQDEIEKLLAASVGNPDALHRAFVSLYALDRSFALPHQSGVERCLALVGSLPRPVQEDFIRTFAAAQADTGDRATAPALRSYRDVMQSEALLPGKVSERLQSDQRQFMTDLFAAAAILSGKEPPSKHAADAAAGTARAALLAMPAPRRRTLREIAQAFWRRIRPSTRLERAQRRVGQIIKQQAVSTSPTRAQWKIMEAAIQDLIDLQRSPARYGDVVQACVSTLTPAQCAALRDLVDSNESLKADVLDRRGGIPRARRLHLLALDAALANEPAIRHTMQAVGNAVAALRGGRDNPEFVEAFVALSACLNQHARELPDARILCEAVLKRLGLPPRHIHEALARLKTLQAHVWIEDKIRMTYRNMSHPRLETISLTPALRALEAALENQAA
>NZ_CP012334.1|WP_066635223.1|2300235_2301654_+|dihydrolipoyl-dehydrogenase
MKTLHTDVAVIGAGTAGLGAYRAAVAAGQRAVIVEGGQYGTTCARVGCMPSKLMIAAAEAAHAAAHGAPFGVHLDGKVRVDGREVMDRVKRERDRFVGFVLEGVENIPAQDKLRGYARFVSDTVLRVDDHTEIHARSVVIATGSTPAVPPPFQALGDRLVVNDDVFYWDDLPGSVAVFGPGVIGLELGQALARLGVRVRVFGVSGSLGGITDPTVRQSAKKAFQEEFYLDPDARVLETTRDGDRVRVRYVALDNTERVEHFDYALVATGRRPNLGGLALQNTSLKLNAAGVPEYDRYTMQAGKSPIFIAGDANSDLPLLHEAADEGRIAGENAAHFPNVKAGRRRAQMAVVFTDPQIAVVGTPYNRLPEGTYVTGEVDFGNQGRSRVMLKNKGRLHVYADRATGRFLGAEMAGPSVEHLAHLLAWSLQQELTVARMLEMPFYHPVVEEGLRTALRDADAQVRQHKPALATAA
>NZ_CP012334.1|WP_066635220.1|2299443_2300172_+|glutathione-peroxidase
MLQAREGQRVPNVSFPVREDNTWKQVTSDDIFKNKTVVVFSLPGAFTPTCSSTHLPRYNELAPAFFANGVDSIVCVSVNDTFVMNEWAKDQESSNITLLPDGNGDFTDGMGMLVDKRNLGFGKRSWRYSMLVRDGVVEKMFIEPEKDGDPFEVSDADTMLNYIAPAARKPDQVVVFSKPGCPFCIEAKALLESKGYAPIDIPLENKVRGRVIGAVSGKATAPQVFINGALVGGLEELKAHFA
>NZ_CP012334.1|WP_066642690.1|2299112_2299313_+|heavy-metal-associated-domain-containing-protein
MVLQYQVPDMSCDHCVRVITQAVTQAVPGAAVQVDLANHRVTVTGTEDNPTVEGAIRGAGYTPTRG
>NZ_CP012334.1|WP_066635214.1|2296405_2298778_-|copper-translocating-P-type-ATPase
MNSYRSASDGLDLSIEGMSCASCVKRVENALAAVPGVRAASVNLATERAHVDRDPAAAVADHALIAAVAKAGYSARPIAPAQDETARQAAARDAQARRLGRRFALALLLTLPVFLLDMGGHLFPALHHALAAHVGTTHLWLLQWALTTLVLAGPGRDFFLKGAAALARRGPDMNSLVAVGAGSAWLYSSVATFAPGWLPEDARHVYFEAAAVIVTLILLGRLLEARAKGRTGAAIARLASLQPRQARVLRGPDTVDLPIEAVRAGDVVRIRPGEKIPVDGTVLDGASFVDESMITGEPIPVEKAAGDAVTGGTLNTQGALTVQVTHTGADTALARIARMVQDAQGAKLPIQSLVDRITYRFVPAIMAIAALAFFAWLALGPQPALPQALVHAVAVLIVACPCAMGLATPMSIMVGTGRAADMGVLFRQGDALQRLRDVKTVAFDKTGTLTLGKPALTNVAVTPPFRREDVLAWTASVQAASEHPIASAIVAAAREAGLPMAPVGGFLAISGAGVRGDVQGRQLIVGGERLMREQGIDTNTLAATADAWARAGKTAVYVAVDGAAAAVMAVEDPIRETSAAAIAALHAAGVRTVMITGDNRHTAHAVAQALGIDEVRAEVLPEGKVQAVRALREEAGAPPAGRPLLAFVGDGINDAPALAAADVGIAIGTGTDVAIDAASVVLMAGDPAGVPRAMAISRATLANIRQNLFWAFFYNVALIPLAAGVPALFHGPSLSPVFAAAAMALSSLFVVGNALRLRAFRAPGNTRRPATAGTQGGGHAPALSSGARTP
>NZ_CP012334.1|WP_066635238.1|2311519_2312368_-|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD
MTARIIDGSALSQRIRDDVAHRVAELAKQGVRPGLAVVLVGDNPASQVYVRNKVLACERAGLHSVKEQYPATMSEAELLQRIAVLNGDPTIHGILVQLPLPPHMDAHKVIEAIAPEKDVDGFHISNAGLLMTGQPLFRPCTPYGVMKMLESEGVALRGAEAVIVGASNIVGKPMAMLLLAAGATVTLCNSKTRDLGAHTRRADVLVVATGKPGIVRGDMIKPGAVVIDVGINRGEDGKLRGDVDFDSAVQVAGAITPVPGGVGPMTIAMLLVNTVEAAERLR
>NZ_CP012334.1|WP_066635243.1|2312364_2312991_-|response-regulator-transcription-factor
MNTPNPSSTVFIVDDDEAVRDSLRWLLEANGYRVRAYASAESFLEDYDPNQVGVLIADVRMPGMSGLELQEQLIARKAPLPIVFITGHGDVPMAVTTMKKGAIDFLEKPFNESDLREIVARMLEQATQRVSKFQAQRDHEAMLARLTAREQQVLERIVAGRLNKQIADDLGISIKTVEAHRANIMEKLEVTTVADLMKVALAKPEAHA
>NZ_CP012334.1|WP_066635245.1|2312987_2314742_-|PAS-domain-containing-sensor-histidine-kinase
MASAPKSNIPTPFHDHARLRRRGVYWLTPVVVLILYICVMGVFFWLQRIHDDSVMFVTIDQEMRQQRLLWVVLALSCVIVISLLMLWRYTRFRSHAEAALIAETGFRRAMENSMSTGMRVLDMEGRIAYVNPAFCRMIGWNEADLLGRSPPFPYWVPGRHDQHQHTLDILLSGKTPSSGLEVEAQRRDGSRFTARMYVSPLLDPNGNQIGWMTSMTDITEPKRIREALTAAHERFMTVLEGLDDAISVTADTHDGLELLFANRTYRRVFGAQTGGHDELLAGRRGRFTDESVEVFAPSVQRWFEVHHRMLAWTDGRRVRLQVARDITERRQHEEASRVQQEKIQLTSRLTTMGEMASSLAHELNQPLTAISNYSMGAVALVKAGHTNPRMLLPALEKAAAQAERAGKIISRIREFVKRSEPRRQRVSIAGIVDNAIGFAEIDARKRRIRIERFVPSNAPDVLADPILIEQVLLNLLKNGLEAMENSDSDELKVAVILHEQHIEVAVVDRGHGLADPERLFEPFFSTKAQGLGMGLNICRTIIESHHGRLWADPNPAGGTIFRFTLPCAAPQAQSQNDQSEELHA
>NZ_CP012334.1|WP_066635246.1|2315001_2317710_+|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type
MSSNALAGAQTAANDEDTLETQEWLEALAAVLDREGPERAHYLLERLIDEARRSGAHIPYSPNTAYVNTIPPGLEPAHPGNLELEARIRSYVRWNAMAMVVRANRHSPPDGGDLGGHIASFASLATMISTGQNHFWHGESEGHGGDLVYFQGHSSPGVYARAFLEGRLTEEQMDHFRQEVDGKGLSSYPHPKLMPEFWQFPTVSMGLGPITAIYQARFLKYLHARGLANTANRKVWVFCGDGEMDEPESLGAIALAAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGDFRGSGWNVIKLIWGGYWDPLLAHDKEGILRRVMEETVDGEYQAYKANDGKFVREKFFGKHPKLLEMVARMSDEDVWRLNRGGHDPHKVYAAFEAASSHKGQPTVILAKTIKGYGMGHVGQAKNPTHQQKKLDVAAVREFRDRFGIPIPDDKLEELPFFKPAEDSPEMKYLHERRKALGGYLPKRRTKADEQLKAPALEAFKPVLEATAEGREISTTQAFVRSLNQILRDKELAPRVVPILADESRTFGMEGLFRQIGIYAPEGQKYTPVDKDQVMYYKEAADGQLLQEGINEAGAMSSWIAAATSYSTNNRIMVPFYVYYSMFGFQRIGDLAWLAGDMQARGFLIGGTAGRTTLNGEGLQHEDGHSHLMAATIPNCLPYDPTYAHEVAVIIQDGLRRMVQNQENVYYYLTVMNENYPHPGLKPGDEEGIVRGMYKLKTVGKGKQRVQLMGSGTILREVEAAAALLDTDWGVASDIWSVTSFTLLRREGQDIDRHNLLHPTEKKPQAPYVTQQLEKTEGPIIASTDYMKLYADQIRPFIPKGREYRVLGTDGFGRSDFRYKLREHFEIDRHFVAVAALKALADEGAIPASKVAEAIKKYGINPEKANPQYA
>NZ_CP012334.1|WP_066635252.1|2317722_2319414_+|dihydrolipoyllysine-residue-acetyltransferase
MSNTVEIKVPDIGDFKEVEVIEVLVAPGDTIKPEQSLITVESDKASMEIPSSEGGVVKSVKVKVGDKVSMGTVVLELEAGGAAEAPAAAPAKQEEKPAAQPQSQPAQAAAQPQAAAPAPAPAGGGEAVIEVPDIGDFKEVEVIEVMVAVGDTIKTEQSLITVESDKASMEIPASQGGVVKEVRVKVGDKVSKGTPLVVVEGGAPAAAPSGQAAAPAPAAAPAQAAPASAAAAAPAPAAAARPAPPAAALPAADLKPGQLPHASPSVRKFARELGVDLARVAGSGPKGRITQEDVRGFVKQALAGGAPAAAGAAAGGNVGGLNVLAWPQIDFSKFGPVEAKPLSRIKKISGANLHRNWVMIPHVTNNDEADITDLEALRVTLNKENEKAGIKVTMLAFLIKAIVAALKKFPEFNASLDGDNLVLKQYYHIGFAADTPNGLVVPVLRDADKKGILDLARETSEMARKARDGKLSPSEMQGGCFSISSLGGIGGTHFTPIINAPEVAILGVSRSEFKPVWDGKQFVPRLKLPLSLSYDHRVIDGAAAARFNAYLGALLADFRRIAL
>NZ_CP012334.1|WP_066635255.1|2319426_2321238_+|dihydrolipoyl-dehydrogenase
MSNTVEIKVPDIGDFKEVEVIEVLVAAGDSIKAEQSLITVESDKASMEIPSSQGGVVKAVKVKVGDKVSMGTAILDLEPAEAGAAQAAPVQAAAAPAPDASAPAPAAEKSAPPPAAGAAAAVAPAAATYSGGVDIECDMLVLGAGPGGYSAAFRAADLGLKTVLVERYSSLGGVCLNVGCIPSKALLHVAAVMEEAKALADHGISFGEPKIDLDKLRSFKDSVVGKLTGGLGGMAKMRKVTVVTGVGEFADPHHMTVKGADGKTQTVRFKQAIIAAGSQAVRLPFMPDDERVVDSTGALLLRGIPKKMLIVGGGIIGLEMGTVYSALGARLDVVEMLDGLMQGADRDMVKVWQKMNTPRFDNIMLKTKTVAAEARKDGIYVSFEGEGAPKEPQRYDLVLQAVGRSPNGKKIGADKAGIAVTDRGFIPVDQQMRTNVPHIYAIGDIVGNPMLAHKAVHEGHVAAEAASGEKSFFDARVIPSVAYTDPEVAWVGLTEDDAKKQGIKIEKGVFPWAASGRAIANGRDEGFTKLIFDADNHRILGGGIVGTHAGDLISELALAVEMGADVVDIARTIHPHPTLGESVGMAAEVAEGVCTDLPPVKKK
>NZ_CP012334.1|WP_066635258.1|2321401_2322175_-|cephalosporin-hydroxylase
MNDSFQKEVAARIDANAHDDALKQAARGFLLASIAPKYSYNFNWLGRPIIQYPQDMVAMQELIWTVKPDLIIETGIAHGGSLILSASMLALLDMEEAIAAGTTIDPRQSRRKVVGIDIDIRPHNREAIAAHAMSSRIQMIQGSSIAPEVVDQVRALAAGHQTVLVCLDSNHTHAHVLAELEAYAPLTSVGSYCVVFDTVVEDLPASLSNDRPWGPGDNPKTAVWDYVRRHPSFEIDRDIENKVLISVAPDGYLKRTS
>NZ_CP012334.1|WP_066642702.1|2322167_2323217_-|class-I-SAM-dependent-methyltransferase
MSEILYEQRDFPVFQNRMYATRAAARQCPKGDIRLAQDPNTGIVANLAFRPELMVYDEHYQNEQGNSPSFQRHLADVGDIVERLLGRQSLVEVGCGKGYFLETLADRGCDIAGFDPAYEGENPRIRRELFAPSLVGRGAGLILRHVLEHIQDPLPFLRQLAQANGHAGRIYIEVPCLDWILAHKAWFDFFYEHVNYFRLDDFHRIFDRVIESGRIFGGQYLYVVADLGSLRQALPPAQPVGLPDGFLSSIERLGASRTGAGVVWGGASKGVIFALLMERRGRAIDTIIDINPAKQGKYIAATGLQVSTPEAALGGLPAGAPIYVMNSNYLPEIKDMTGNAYTYIGVDDE
>NZ_CP012334.1|WP_066635261.1|2323220_2324048_-|NAD(P)-dependent-oxidoreductase
MKQKVLLTGASGFVGRHVLARLHAAGVPLRVIARPRRDRGADWPPGAEIIETGDLFAEPAAWWADVAAGCSRVLHLAWYVEPGLYLRSPRNLDCLAGTLAMARGCARAGVSRFVGVGTCFEYDTSAGHLSVDTPLRPMSPYAAAKAAAYLALDGFLREAGISFAWCRLFYLHGEGEDPRRLIAYVRQRLAQRLPVELTHANQVRDYMPVEDAARDLAQHLMGERQGAINVCSGRAVTVRALVEALADASGHRDLLRFGARPDNDIDPPVIVGVKD
>NZ_CP012334.1|WP_066635265.1|2324044_2325268_-|methyltransferase-domain-containing-protein
MNCRHCAHPLQHVFLDLGYAPPSNAYLTREDLSRPEKHFPLRVRVCEACWLVQTEDYAQADELFNAEYAYFSSTSTGWLAHARRYAQDMSRRLALNAESLVIEVASNDGYLLRNFIEMGVPCLGIEPTDSTAEAAERLGIPVLREFFGRALGERLAREGRQADLIAGNNVYAHVPDINDFTQGLQAALKPAGTITLEFPHVMQLIRQVQFDTVYHEHFSYLSLYTVQRIFGAAGLRIFDVQTLDTHGGSLRVFGCHETDGRPSTDAVEHVLAQEAAAGLRDLDTYLGFQQRADRVKDDLLAFLLEQKKAGRKVVAYGAAAKGNTLLNYAGIKPDLLPLVCDAAAAKQGKFMPGSHIPILAPDALAESRPDFVLILPWNIAPEVRRQNASLAERGVRFVTAVPGLVVQ

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Crispr_ID: NZ_CP012334_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012334_8

2457657-2457757

Orphan

Consensus_repeat	Method
GGCGGAGCCGGATCCGCGGCGTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012334_8

>merge|NZ_CP012334|8|2457657-2457757|CRISPRCasFinder
GGCGGAGCCGGATCCGCGGCGTCCCCGACCGAGTGGCACCCGTTTCATGCGGCGGGTGGTGTGAGGAAGGCCACCCTGGCGGAGCCGGATCCGCGGCTCCT

>NZ_CP012334|8|8|2457657-2457757|CRISPRCasFinder
GGCGGAGCCGGATCCGCGGCGTCC	CCGACCGAGTGGCACCCGTTTCATGCGGCGGGTGGTGTGAGGAAGGCCACCCT
GGCGGAGCCGGATCCGCGGCTCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012334.1\|WP_066635639.1\|2466354_2466894_+\|chromate-transporter	unknown	unknown	gnl\|CDD\|376780
NZ_CP012334.1\|WP_066635603.1\|2455148_2455553_+\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|366663
NZ_CP012334.1\|WP_066635591.1\|2450589_2451537_+\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|234713
NZ_CP012334.1\|WP_066635600.1\|2453976_2455038_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP012334.1\|WP_066635606.1\|2455589_2456483_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182137
NZ_CP012334.1\|WP_066635617.1\|2459865_2460861_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223787
NZ_CP012334.1\|WP_066635615.1\|2458818_2459799_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP012334.1\|WP_066635585.1\|2448332_2449493_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NZ_CP012334.1\|WP_066635620.1\|2460870_2461761_+\|xanthine-dehydrogenase-family-protein-subunit-M	unknown	unknown	gnl\|CDD\|224238
NZ_CP012334.1\|WP_083229092.1\|2464775_2465621_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176865
NZ_CP012334.1\|WP_066635609.1\|2456601_2457594_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP012334.1\|WP_066635637.1\|2465779_2466358_+\|chromate-transporter	unknown	unknown	gnl\|CDD\|376780
NZ_CP012334.1\|WP_066635597.1\|2453074_2453914_+\|iron-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NZ_CP012334.1\|WP_083228770.1\|2451562_2452240_-\|DNA-oxidative-demethylase-AlkB	unknown	unknown	gnl\|CDD\|237957
NZ_CP012334.1\|WP_066635588.1\|2449626_2450583_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP012334.1\|WP_066635594.1\|2452400_2453063_+\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|238449
NZ_CP012334.1\|WP_083228771.1\|2462259_2464722_+\|xanthine-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|224446
NZ_CP012334.1\|WP_066635641.1\|2467010_2467784_+\|phytanoyl-CoA-dioxygenase	unknown	unknown	gnl\|CDD\|227609
NZ_CP012334.1\|WP_066635612.1\|2457822_2458515_+\|4-carboxy-4-hydroxy-2-oxoadipate-aldolase/oxaloacetate-decarboxylase	unknown	unknown	gnl\|CDD\|181735
NZ_CP012334.1\|WP_066635632.1\|2461757_2462276_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991

Protein	Function_ID	Function_description	E-value
NZ_CP012334.1\|WP_066635639.1\|2466354_2466894_+\|chromate-transporter	gnl\|CDD\|376780	pfam02417, Chromate_transp, Chromate transporter. Members of this family probably act as chromate transporters. Members of this family are found in both bacteria and archaebacteria. The proteins are composed of one or two copies of this region. The alignment contains two conserved motifs, FGG and PGP.	8.47421e-31
NZ_CP012334.1\|WP_066635603.1\|2455148_2455553_+\|transcriptional-repressor	gnl\|CDD\|366663	pfam01475, FUR, Ferric uptake regulator family. This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.	1.17266e-44
NZ_CP012334.1\|WP_066635591.1\|2450589_2451537_+\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|234713	PRK00283, xerD, tyrosine recombinase.	9.87903e-151
NZ_CP012334.1\|WP_066635600.1\|2453976_2455038_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	2.85221e-46
NZ_CP012334.1\|WP_066635606.1\|2455589_2456483_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|182137	PRK09906, PRK09906, DNA-binding transcriptional regulator HcaR; Provisional.	1.09246e-64
NZ_CP012334.1\|WP_066635617.1\|2459865_2460861_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	2.01702e-08
NZ_CP012334.1\|WP_066635615.1\|2458818_2459799_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	6.18859e-134
NZ_CP012334.1\|WP_066635585.1\|2448332_2449493_-\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.93276e-78
NZ_CP012334.1\|WP_066635620.1\|2460870_2461761_+\|xanthine-dehydrogenase-family-protein-subunit-M	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	2.76375e-64
NZ_CP012334.1\|WP_083229092.1\|2464775_2465621_+\|SRPBCC-family-protein	gnl\|CDD\|176865	cd07823, SRPBCC_5, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	1.18492e-45
NZ_CP012334.1\|WP_066635609.1\|2456601_2457594_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	3.43922e-137
NZ_CP012334.1\|WP_066635637.1\|2465779_2466358_+\|chromate-transporter	gnl\|CDD\|376780	pfam02417, Chromate_transp, Chromate transporter. Members of this family probably act as chromate transporters. Members of this family are found in both bacteria and archaebacteria. The proteins are composed of one or two copies of this region. The alignment contains two conserved motifs, FGG and PGP.	4.39494e-33
NZ_CP012334.1\|WP_066635597.1\|2453074_2453914_+\|iron-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	3.25074e-72
NZ_CP012334.1\|WP_083228770.1\|2451562_2452240_-\|DNA-oxidative-demethylase-AlkB	gnl\|CDD\|237957	PRK15401, PRK15401, DNA oxidative demethylase AlkB.	3.22519e-136
NZ_CP012334.1\|WP_066635588.1\|2449626_2450583_+\|hypothetical-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	1.73832e-33
NZ_CP012334.1\|WP_066635594.1\|2452400_2453063_+\|carbonic-anhydrase	gnl\|CDD\|238449	cd00884, beta_CA_cladeB, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	9.20108e-97
NZ_CP012334.1\|WP_083228771.1\|2462259_2464722_+\|xanthine-dehydrogenase-family-protein	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	0
NZ_CP012334.1\|WP_066635641.1\|2467010_2467784_+\|phytanoyl-CoA-dioxygenase	gnl\|CDD\|227609	COG5285, COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism].	1.67571e-35
NZ_CP012334.1\|WP_066635612.1\|2457822_2458515_+\|4-carboxy-4-hydroxy-2-oxoadipate-aldolase/oxaloacetate-decarboxylase	gnl\|CDD\|181735	PRK09262, PRK09262, hypothetical protein; Provisional.	1.05817e-136
NZ_CP012334.1\|WP_066635632.1\|2461757_2462276_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	1.3767e-68

>NZ_CP012334.1|WP_066635609.1|2456601_2457594_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MRANSALSKLFRGLGLATTVAFAALPAMSRAADFPSKPIKIVVPYAPGGAVDIVTRLVAQKMGETLKQSIIIDNRPGGATNIGMDIVARAPGDGYTLLTASNSLASNAALFTNLNFDPAKDLIPVGAIGYAPLVVVVPSSSPFKTLQDMIAYGKANPDKLTYASAGNGSSGHLASELLKGEGKFDALHVPYKGGAPAITDMLGGRISFMSINPVEAIPHIKAGKMTTLAVLDSKPSALLPGVPRVASLGLPNAAASVWWGLCAPKGTPADVVAKLNEALNKALADNDVQTRLSELGAVTTPGSAADFGKFVQEETVKWSRVIKAANIKAD
>NZ_CP012334.1|WP_066635606.1|2455589_2456483_-|LysR-family-transcriptional-regulator
MDFRQLRYFVAVAEELSFSAAARRLHVSQPPLSMQVKSLEDELGATLLHRTKRRVELTEAGALFLDQARRALQHLERAGDVVRQALQGEAGEIRIAFTASVPMFEAFPRIVQDFRTRHPSAKADLLHMSTGQQLQALADRGIDVGFLRPSILFCPPPNIRVLTLWSDRLMAALPAEHPLACTDTPLPMAALAGESFILFPRGLGCGLFEHVSVLASRAGFALQIGQEAREGATIVGLVAAGMGVSILPETYAKTGIPGVVYRPLDTPDAGSQILLAHRQDNDTPLLARFFEAATACR
>NZ_CP012334.1|WP_066635603.1|2455148_2455553_+|transcriptional-repressor
MTDSVDLKGIGLKVTFPRLKILDLFRNSEQRHLSAEDVYRHLMNEGVEMGLATVYRVLTQFEQAGLLKRSQLGGNKAVFELNDGERHHGHLVSTSTGIVEEFVDPEIERRLRQIADDMGYSLTEFTITIFATPK
>NZ_CP012334.1|WP_066635600.1|2453976_2455038_-|AI-2E-family-transporter
MSNSNLHYRTFLCLLIVVSIAFGWILWPFYGAVFWGTILAIIFSPLHRRVLARLGKRRNLAALITLLLCVLIAILPMILITGSLVQEGTALYQQMKSGNLNFGLYFERVVNALPPSVHAMLDRFDVSDIRSVQQKLSTAAVQASQFLATQAFSIGQDTFQFVISFGVMLYLLFFLLRDGSSLSRSISRAIPLSEAYKQHLTRKFTTVIRATIKGNVAVAATQGLLGGLAFWVLGIQGSLLWGVLMAFLSLLPAVGAALIWVPVAVYFLVTGALWQGVGLIAFCVLVIGTVDNIMRPILVGKDTKLPDWVILISTLGGMALFGLNGFVIGPLIAALFTAVWDLFALEGEAPAED
>NZ_CP012334.1|WP_066635597.1|2453074_2453914_+|iron-ABC-transporter-substrate-binding-protein
MPAPSNLPRRRALRALGAAAVGLCAAPVGRIWAQPAPLRIGVIASVANEATEIAIAQARDEGVNARLVEFADWVMPNVAVADGSIEANFFQHEPFLDLFNRSRGVNLQPIAYGYSTTMGLFSKKVKRGEALPRGASIGIPSDPVNTGRALLLLQSMGLIRLKAGAAERATLLDVESNPLHLKFVAIEGAQAARAFDDVTASATYTTFAKHGGLDESDGLAFDNHDPENVRRYAIRWVALPEHAEDQRLLKFIAVYQRSPEVKATLRRLYGNLIEFPWAG
>NZ_CP012334.1|WP_066635594.1|2452400_2453063_+|carbonic-anhydrase
MEDTFNFPRRLTDGYQDFLAGRFPAERNRYRQLAEGQNPEIMVIGCCDSRVAPELIFDAGPGEMFVLRNVANLVPPYEPDSHYHGTSSAIEFAVNGLNVKHIVVMGHASCGGIRSYYDDAEPLAKGDFIGKWMSQIEATARKVDLTGERQTDLRRLELRVVEHSLKNLMTFPYIRQRVERGELQLHGAYFGVATGLLFIRNPQSGEFMPFGEGPGDDGAA
>NZ_CP012334.1|WP_083228770.1|2451562_2452240_-|DNA-oxidative-demethylase-AlkB
MPAPISPPSSGNLFGSPDEEAPWDEPIAPGAVLLRRYACGQAPALLAAVKAIAAAAPFRHLLTPGGQRMSVAMTNCGAQGWISDRRGYRYGPRDPLSDQPWPAMPELLAALARDAAARAGYADFAPEACLINLYRPGARLTLHQDRDELDLHAPIVSVSLGLPATFLFGGLQRADRPRRFPLVHGDVAVWGGPSRLAFHGIAPLADGIHPATGASRINLTFRKTR
>NZ_CP012334.1|WP_066635591.1|2450589_2451537_+|site-specific-tyrosine-recombinase-XerD
MPNAPRSAAAEPPSLQSRRDIDPTVAEFLDALWLEDGLSRNTLGAYRNDLAAFDVWLHAHEGRRISEARAGDIESWFASVHADTRATTANRRLSALRRYFQWALRERRIAQDPCLSVRSARQPLRTPKILSEAQVEALLRAPRVETELGLRDKAMLETLYATGLRVSELVGLAALDVNLNEGVVRVVGGKGGKDRLVPLGAEAAHWVDRYVRHARPLLLAGRLCDAMFVTVRGDAMHRQTFWLMVGRYAREADIRAPISPHVLRHAFATHLVNHGADLRVVQMLLGHADISTTQIYTHVARERLKALHAQHHPRG
>NZ_CP012334.1|WP_066635588.1|2449626_2450583_+|hypothetical-protein
MKDIETLLLEYGPLLVFLNVLLEQAGLPIPAYPLLVVAGALAAHGHLFWPLTLAAAVLACLIADAGWYAGGKRFGSGLLSTVCRVSISRDSCIRQTQSLYWRTGPRVLLVAKFLPGASALSTVMSGFAGLPFRTFMTYDAAGSLIWAGSALIVGIAFNDMVGQVLGVLGDYGGYGLLTIAVVLVAYLAYRWARRKRTIRRFAHVRRVTLDELEEMQAQGRVPVLLDVRASSDDPLPGAIPVDPHARIGEEPYQWPLDAHIVVYCACPEEISAAVLADRLLRAGYRNAGALAGGYNAWVARQRAADAAVAPESVRMSGG
>NZ_CP012334.1|WP_066635585.1|2448332_2449493_-|metallophosphoesterase
MRRPPFITRILAIGILLHVYIGLRLIPDAPVSDAIRWLAGLYLVASCVLIPLGTRARRMAPRWSRQAAWTGLTAMGFFSSLLVMTVLRDVVLAAVWAAEALRGVPHGDASVRAASALAVPVLALLVTLLGLFNARRLARVVTVDVPIAGLPPALAGFTIAQISDVHVGPTIRRPYVEAIVAAVNALSADVVAITGDVVDGPVDQLSPHTAPLAGLAGRYGTYLVTGNHEYYAGAREWVAEFQRLGLQVLSNRHVVISHNGARLVLAGVTDYTAGQFDPAQRSDPRGALLGAPADAAVRILLAHQPRTAIAAEPAGYTLQISGHTHGGQFLPWNFFVRLQQPFTAGLRKMGRLWVYTSRGTGYWGPPKRVGAPSEITRIRLVPARGG
>NZ_CP012334.1|WP_066635612.1|2457822_2458515_+|4-carboxy-4-hydroxy-2-oxoadipate-aldolase/oxaloacetate-decarboxylase
MSFAVRNIQRADGAIITRLAAAGTATVHEAQGRSGLLQPYMRPVYAGAAIGGSAVTVLAHPGDNWMLHAAIELCQPGDVMVVACSAPNTDGMFGELLATSMRARGIVGLVIDAGCRDVQALKDMQFPVWSKAISAKGTIKATPGSVNLPVVCAGAMVSAGDVVVADDDGIVIVPRRRAAEVAQACEARLQKEALNRKRLAAGELGLDIYGMRDKLREAGLVYVDSEADLP
>NZ_CP012334.1|WP_066635615.1|2458818_2459799_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MKLRKLMLGAATAALCLGGGTAAVAEDAASFPSRNFDIIVTFPPGGGTDMLARLVGNYMADTLGKGAVVENRPGASGNVGARVVKERAPDGYSLLMVNSSFAVNPGVFKTLPFDPKKDFDAIINIAYVPSVLVVPPNSPYRTLADVTEAAVKTNDVSFGSCGNGTPQHLAGELFKLQAKVNMVHVPYKGCGPALNDVVGGQIGLAVITASSALPFIKAGKLRALAVTSKDRSKLMPDVPTVAEQGYPGYELTQWHGLLAPAGTPGDIKQKLYDGVAKIMQRPDVQQKLADLGYDTASDGPVAFQKMVAGDIDKFTALAHKIGLSAD
>NZ_CP012334.1|WP_066635617.1|2459865_2460861_+|ABC-transporter-substrate-binding-protein
MSNKLRISLACGAYDRTQALFDGRAPIEGCEVAAVPVEPEEAFHRAFRYQEFDVTEISMSSHMMTTARGDNEYVAVPAFISRVFRQSGIYIRTDRGIKTPQDLRGKVIGVPEYQITANVWIRGILEDEYGVKPSDIKWRRGGIEEPGRGERAPIELGKEIDLRQIPDDKTLSGMLEAGEIDGYIGARAPSCFLRGAPHVGRLFGDYIEAEKDYYRRTGIFPIMHMVGIRKSLVEENPWLPVSVYKAFLKAKALAMKELNEICHLAVTLPWMVHHYNEARSIMGEDYWPYGLEANRHTIETFARYHYEQGLSKRKVAPEELFARSALDLSKI
>NZ_CP012334.1|WP_066635620.1|2460870_2461761_+|xanthine-dehydrogenase-family-protein-subunit-M
MKAPVLRYLAPRSVDEALHMLGNEENARILAGGQSLVAMLNMRFAFPDCLVDINRIPELAYIREDEAGGAIEIGAMTRQRDVEFSPLVAARLPLWREAVLHVGHRQTRNRGTVGGSLCHLDPSAEIPTVAMAMDATIVARSRRGTREIAIADFPAAYMTPAVASDEMVTAVRVPIWPRRHGHAFVEFARRHGDFAIVSCAALISLDEQGRIARASLTLGGVAVAPMRMRDAEGGLVGRAPDEETLARAAALCGRIDATADSYVPAWYRRRLAAVLARRALGQAIQRAGAHEELASS
>NZ_CP012334.1|WP_066635632.1|2461757_2462276_+|(2Fe-2S)-binding-protein
MNQDDRAEARPIRLVVNGESRCGTTEPRVHLADFLRGELKLTGTHVGCEHGVCGACTVLVDGHSARACLMLAVQAEDCRVETIEGLAGKDGTPHALQAAFHELHALQCGYCTPGILMSLVELLRDHPDPDEAAVRDVLSGHLCRCTGYQNIVAAALRAARRLREGQVDGRIA
>NZ_CP012334.1|WP_083228771.1|2462259_2464722_+|xanthine-dehydrogenase-family-protein
MDVSLERKAPEGAPDAGQRAATVSNPGIGQPARRIEDQALLTGTARFLDDIAVDAPLHACFVRSPHAHARILSIDAAAARAMPGVAAVYAARDLFGELTEWRMPLGFPLANLPADTTPFVLAPSEVAFVGEAVAIVVAASRHVAEDAAAAVAVDYDILPAVADCRDALDPAAPRVRTELASNALQEYALSYGDCDAAFAAAHRVVQEKFHVHRGCAHPMEGRGVLARPDPASGELTVWSSTQMAHELHYTIALMLGHPEDLLRVVTPEVGGGFGAKFMIYPEEVAVPAAARKLGRAVKWVEDRRENFVSAIQERDQYWSMAVAVDERGCLLGLRGRMVHDHGAYTPQGTNVPYNAASSMTGPYIVPAYHLDVAVAYTNKVPVATVRGAGYPQAAFVMERLLDRVSIELGIDRAECRRRNLIPAEKIPYTKPLKSRAGVPLTIDSGDFPALQARALQAIDYDGFEARRQASRDRGLCRGIAVANSVKPTGRGPFESARVRVQPSGQITVYTGALAMGQGIKTTLAQICAGHLGVAPEAVQVIAGDTAFIGYGMGGFASRQAIMAGTAVDQAAARLRRKILDAAAVLLHALPDDLTLANGEVVPRSGAGSSVALARLAMLLKGVPGYALPVPGDPGLDETVHFHCDAQAYAGASHACEVEVDALTGAVAIVRYVAVQDSGRIINPMLAEGQVHGGVVHGIGNALFEWMGYDSGGQPLTTTFAEYLLPTAPEVPNVEVIFQPSITPLNPLGVKGVGECATIPVAAAVIGAVEHALAGHGVRLSEFPLTPVRLLECLDAAGEQGVGANAPGPDQRELPSPVDRP
>NZ_CP012334.1|WP_083229092.1|2464775_2465621_+|SRPBCC-family-protein
MPLEQAWPLMLDVPRILPCLPGARLTEVLDGNRYKGAVSVRLGPIRLSFDGQAALVRKDDQNHVAWLEGSGIDPKGRGSARSEFSFALAPAPDGGTRVTVTTQLALSGSVAQYGRGSGMIAEVASQILGQFERNLAQSLAGDGSGEGLPGAPAQAVPGTEGAHMGDGPAHRGPYPSAPHSTAPQTAIPTGGQGRAPAAYPAAAGAFSAQGVDVQTVLLQAQAVLGQAQAILALAQSRMVQGRHGAAAHAAPAGELNMLSIGLKAMWARLRGGLGDLFGRRP
>NZ_CP012334.1|WP_066635637.1|2465779_2466358_+|chromate-transporter
MNSASDSTVPALEPLADPPTVAQLFLGFFWLGMTAFGGALPLARRMMVEKHRWISSEEFTTLLGLCQFLPGGNIINLSVALGMRFRGVPGAVGAMLGFVLMPTVVVIMLGVVYEHYQDDPHVRHLFAGLAAAAAGLLISLTLKIGAPLLKNRWGTVVAVLCFIAIAVLRVPLLPTMLVLTPLSILVSWRMRR
>NZ_CP012334.1|WP_066635639.1|2466354_2466894_+|chromate-transporter
MTQILIQLAILFTQLSLLAFGGGNTILPEMQRQVVDVHHWMTAENFTALFALAQAAPGPNLMIVPMVGWHIAGLPGMLVSSLAKFVPSSLVVILVMRLWDRFKDKPWRAAAQAGIFPVTVGLLAASAALITEASVDGWLLGAIAAVVAVLGWRTRLHPLWLLLGGAVVGLAAMGLPGIS
>NZ_CP012334.1|WP_066635641.1|2467010_2467784_+|phytanoyl-CoA-dioxygenase
MSFPLTTAQLQTLREQGFVVAREFVPAVQREALRALAQAQLDQAVAPVEYEADLAYPGAPASRNAEGGGTVRRLLDAYGRDPLFAAWATAPAVASSLHRYFGQAAVLSRAHHNCVMTKHPRFGSLTGWHRDIRYWSFDREDLVSTWLALGPETAHNGGLWLVPGSHRMTLPADRFDAAQFLREDLPENAALIATAVSPELAPGDVLFFHCRTLHAAGRNQSDRVKLSVVHTYHAVETHPLPNTRSASKPEVLLDPAT

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Crispr_ID: NZ_CP012334_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012334_9

2802710-2802912

Orphan

Consensus_repeat	Method
CGGCCCTCTTCAGCGAACCGGCC	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP012334_9

>merge|NZ_CP012334|9|2802710-2802912|CRISPRCasFinder
CGCGGCGCGGCAGGGAACCGGCCATCCGGGGCCAATAGCCCAGGTGCCGGCAATCGCTCAACCGGCCCGGATCGCTCGACAGCGGCGAACCGGCCCGCGTCTGCGGATCGGCCCTCTTCAGCGAACCGGCCGACGTCTGCGGACCGGCCTTCTTCAGCGAACCGGCCAACGTCCGCGGAACGGCCTTCTTCAGCGAACCGGCC

>NZ_CP012334|9|9|2802710-2802912|CRISPRCasFinder
CGCGGCGCGGCAGGGAACCGGCC	ATCCGGGGCCAATAGCCCAGGTGCCGGCAATCGCTCAACCGGCCCGGAT
CGCTCGACAGCGGCGAACCGGCC	CGCGTCTGCGGATCGGCCCTCTTCAGCGAAC
CGGCCGACGTCTGCGGACCGGCC	TTCTTCAGCGAACCGGCCAACGTCCGCGGAA
CGGCCTTCTTCAGCGAACCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012334.1\|WP_066642869.1\|2806140_2807265_+\|Ldh-family-oxidoreductase	unknown	unknown	gnl\|CDD\|376860
NZ_CP012334.1\|WP_083228811.1\|2812387_2812939_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012334.1\|WP_066636313.1\|2800027_2800510_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP012334.1\|WP_066636318.1\|2805343_2806129_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293806
NZ_CP012334.1\|WP_066636325.1\|2807280_2808228_+\|hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240650
NZ_CP012334.1\|WP_076879695.1\|2797576_2798311_-\|metallophosphoesterase-family-protein	unknown	unknown	gnl\|CDD\|378975
NZ_CP012334.1\|WP_066636327.1\|2808300_2809107_+\|aldolase	unknown	unknown	gnl\|CDD\|226356
NZ_CP012334.1\|WP_066636315.1\|2800983_2801538_+\|lipid-binding-SYLF-domain-containing-protein	unknown	unknown	gnl\|CDD\|211400
NZ_CP012334.1\|WP_066642864.1\|2795130_2796108_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|225722
NZ_CP012334.1\|WP_066636288.1\|2789686_2792845_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NZ_CP012334.1\|WP_066636298.1\|2796179_2797397_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|178031
NZ_CP012334.1\|WP_066642871.1\|2811261_2812161_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238636
NZ_CP012334.1\|WP_083228810.1\|2809147_2810209_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP012334.1\|WP_083229107.1\|2803211_2804162_+\|DUF2950-domain-containing-protein	unknown	unknown	gnl\|CDD\|371539
NZ_CP012334.1\|WP_066636302.1\|2798451_2798997_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP012334.1\|WP_066636292.1\|2792841_2794362_-\|tricarboxylate-transporter	unknown	unknown	gnl\|CDD\|225870
NZ_CP012334.1\|WP_066636332.1\|2810230_2811205_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP012334.1\|WP_066636311.1\|2798998_2799574_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380339
NZ_CP012334.1\|WP_066636295.1\|2794456_2794963_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl\|CDD\|377815
NZ_CP012334.1\|WP_083228809.1\|2804251_2805250_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176107

Protein	Function_ID	Function_description	E-value
NZ_CP012334.1\|WP_066642869.1\|2806140_2807265_+\|Ldh-family-oxidoreductase	gnl\|CDD\|376860	pfam02615, Ldh_2, Malate/L-lactate dehydrogenase. This family consists of bacterial and archaeal Malate/L-lactate dehydrogenase. L-lactate dehydrogenase, EC:1.1.1.27, catalyzes the reaction (S)-lactate + NAD(+) <=> pyruvate + NADH. Malate dehydrogenase, EC:1.1.1.37 and EC:1.1.1.82, catalyzes the reactions: (S)-malate + NAD(+) <=> oxaloacetate + NADH, and (S)-malate + NADP(+) <=> oxaloacetate + NADPH respectively.	1.68169e-138
NZ_CP012334.1\|WP_066636313.1\|2800027_2800510_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	3.09085e-16
NZ_CP012334.1\|WP_066636318.1\|2805343_2806129_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293806	cd07720, OPHC2-like_MBL-fold, Pseudomonas pseudoalcaligenes organophosphorus hydrolase C2, and related proteins; MBL-fold metallo hydrolase domain. Pseudomonas pseudoalcaligenes OPHC2 is a thermostable organophosphorus hydrolase which a broad substrate activity spectrum: it hydrolyzes various phosphotriesters, esters, and a lactone. This subgroup also includes Pseudomonas oleovorans PoOPH which exhibits high lactonase and esterase activities, and latent PTE activity. However, double mutations His250Ile/Ile263Trp switch PoOPH into an efficient and thermostable PTE. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	4.42769e-28
NZ_CP012334.1\|WP_066636325.1\|2807280_2808228_+\|hydroxyacid-dehydrogenase	gnl\|CDD\|240650	cd12173, PGDH_4, Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains. Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases. PGDH in E. coli and Mycobacterium tuberculosis form tetramers, with subunits containing a Rossmann-fold NAD binding domain. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence.	1.40365e-108
NZ_CP012334.1\|WP_076879695.1\|2797576_2798311_-\|metallophosphoesterase-family-protein	gnl\|CDD\|378975	pfam12850, Metallophos_2, Calcineurin-like phosphoesterase superfamily domain. Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	8.44247e-21
NZ_CP012334.1\|WP_066636327.1\|2808300_2809107_+\|aldolase	gnl\|CDD\|226356	COG3836, HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism].	4.4985e-44
NZ_CP012334.1\|WP_066636315.1\|2800983_2801538_+\|lipid-binding-SYLF-domain-containing-protein	gnl\|CDD\|211400	cd11524, SYLF, The SYLF domain (also called DUF500), a novel lipid-binding module. The SYLF domain is named after SH3YL1, Ysc84p/Lsb4p, Lsb3p, and plant FYVE, which are proteins that contain it. It is also called DUF500 and is highly conserved from bacteria to mammals. Some members, such as SH3YL1, Ysc84p, and Lsb3p, which represent the best characterized members of the family, also contain an SH3 domain, while family members from plants and stramenopiles also contain a FYVE zinc finger domain. Other members only contain a stand-alone SYLF domain. The SYLF domain of SH3YL1 binds phosphoinositides with high affinity, while the N-terminal SYLF domains of both Ysc84p and Lsb3p have been shown to bind and bundle actin filaments, as well as bind liposomes with high affinity.	4.12059e-25
NZ_CP012334.1\|WP_066642864.1\|2795130_2796108_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|225722	COG3181, COG3181, Uncharacterized protein conserved in bacteria [Function unknown].	1.66982e-90
NZ_CP012334.1\|WP_066636288.1\|2789686_2792845_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	4.15822e-76
NZ_CP012334.1\|WP_066636298.1\|2796179_2797397_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|178031	PLN02409, PLN02409, serine--glyoxylate aminotransaminase.	1.72141e-146
NZ_CP012334.1\|WP_066642871.1\|2811261_2812161_+\|amidohydrolase-family-protein	gnl\|CDD\|238636	cd01311, PDC_hydrolase, 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most important intermediate metabolites in the bacterial pathways for various phenolic compounds, including lignin, which is the most abundant aromatic material in nature.	1.68031e-66
NZ_CP012334.1\|WP_083228810.1\|2809147_2810209_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	8.93337e-134
NZ_CP012334.1\|WP_083229107.1\|2803211_2804162_+\|DUF2950-domain-containing-protein	gnl\|CDD\|371539	pfam11453, DUF2950, Protein of unknown function (DUF2950). This is a bacterial family of uncharacterized proteins.	4.26286e-148
NZ_CP012334.1\|WP_066636302.1\|2798451_2798997_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.25611e-08
NZ_CP012334.1\|WP_066636292.1\|2792841_2794362_-\|tricarboxylate-transporter	gnl\|CDD\|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP012334.1\|WP_066636332.1\|2810230_2811205_+\|hypothetical-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	1.09221e-103
NZ_CP012334.1\|WP_066636311.1\|2798998_2799574_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.12977e-15
NZ_CP012334.1\|WP_066636295.1\|2794456_2794963_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	8.4712e-11
NZ_CP012334.1\|WP_083228809.1\|2804251_2805250_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176107	cd08415, PBP2_LysR_opines_like, The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold. This CD includes the C-terminal substrate-domain of LysR-type transcriptional regulators, OccR and NocR, involved in the catabolism of opines and that of LysR for lysine biosynthesis which clustered together in phylogenetic trees. Opines, such as octopine and nopaline, are low molecular weight compounds found in plant crown gall tumors that are produced by the parasitic bacterium Agrobacterium. There are at least 30 different opines identified so far. Opines are utilized by tumor-colonizing bacteria as a source of carbon, nitrogen, and energy. NocR and OccR belong to the family of LysR-type transcriptional regulators that positively regulates the catabolism of nopaline and octopine, respectively. Both nopaline and octopalin are arginine derivatives. In Agrobacterium tumefaciens, NocR regulates expression of the divergently transcribed nocB and nocR genes of the nopaline catabolism (noc) region. OccR protein activates the occQ operon of the Ti plasmid in response to octopine. This operon encodes proteins required for the uptake and catabolism of octopine. The occ operon also encodes the TraR protein, which is a quorum-sensing transcriptional regulator of the Ti plasmid tra regulon. LysR is the transcriptional activator of lysA gene encoding diaminopimelate decarboxylase, an enzyme that catalyses the decarboxylation of diaminopimelate to produce lysine. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.23751e-47

>NZ_CP012334.1|WP_066636315.1|2800983_2801538_+|lipid-binding-SYLF-domain-containing-protein
MAPRSLRILWLAFLVFLTACASQSSSQGDAELEAKSRAALTQLFDTTPKASELRQEARAILVFPDILKAGFLVGGQGGKGVMFSRDGKVLGYYRATALSFGMQAGAQSFSEALFLMTDDAIRYVNTTGEWSIGVGPSVVVMDAGAAKSMTTTTMKSDIYAFIYGQQGLMAGIGLQGQQIRKLDQ
>NZ_CP012334.1|WP_066636313.1|2800027_2800510_-|DoxX-family-protein
MSSTNPAENFWTAWSPRALALLRIVTGLIYLQEGTAKILHWPHVAKFDSVQIYSLLGFAGILDIVGALLLIVGLFTRWTAFILSGEMAFAYFMVFQPRGLFPVQNGGNDTVLLCFILLYLFFAGGGAYALDNLRGNTGRDRIKASSERRLGSAEDVPANE
>NZ_CP012334.1|WP_066636311.1|2798998_2799574_-|helix-turn-helix-transcriptional-regulator
MDINQLIASRIRDLRGKHAWSLDALADRSGVSRSTISLIERGVSSPTAIVLDKLAAALHVPLASLFERPSAEDTPSPISRADKQAVWTDPASGYVRRHLSAAVACPTQLVEIHFPAGQRVSYETSMQEPDVVQQVWMIQGTMEVRVGETTWRLGKGDCLTMKLNQPTAFHNPGRVTARYLVAITAPSQKGI
>NZ_CP012334.1|WP_066636302.1|2798451_2798997_-|GNAT-family-N-acetyltransferase
MTTQANIRIVGAEEARSLAEQLAALLVGCVAGGASVSFIAPLEMSRAVQFWRNVADGIAQGDRILLVAESDERIMGTVQIVIGQPENQPHRADVSKLLVHRDFRRLGLGGKLMAEVDIVAAGAGRTLLVLDTETGSDAERLYVRSGWTRAGVIPDYAVKPFGGLAATTYFYKRLSPSGRGR
>NZ_CP012334.1|WP_076879695.1|2797576_2798311_-|metallophosphoesterase-family-protein
MKIAAISDIHGNLAALDAVLEDIRQQGADVVVNLGDILSGPLQPSATADRLGPLRLPTIRGNHERQLLSGDPSGMGPSDRWAYGSLRDDQFLWLRELPVTLRLTEDVLLVHGTPEDDVAYFLETVTPSGCRPATHDEVKCLAGSCDAALILCGHTHLQRSMKLEDGRLIVNPGSVGLQAYKDDRPFPHRMEMGSPHARYSCVTRVGSEWRVEFRSVQYEWDKAAAMAELNGRPDWGAALRGGRC
>NZ_CP012334.1|WP_066636298.1|2796179_2797397_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MLRLDFHPAGRHFLQIPGPSPVPDRLLRAMSYPTIDHRGPEFGALGLQVLQGIKKIFKTQHPVIIYPASGTGAWEAALSNTMSPGDQVLMFETGHFASLWKKMADGLGLKTEFLGLPGTEGWRRGVQARMIEDRLRADTGHQIKAVCVVHNETSTGVTSDIAAVRRAIDAAGHPALLMVDTISGLACADYRHDEWGVDVSISGSQKGLMLPPGISFNALSPKAIERSQHGGLPRSFWRWSEILETNKTGYWPYTPSTNLLYALHESLEMILAEGLDAVFARHERLARACRAAVQAWGLEIQCVEPECYSPVLTGVVMPAGVDADAVRQLIYERFDMSLGTGLGKVKGRMFRIGHLGDCNDLTLMATLSGCEMGLKLSGVTLAGSGVQAAMDILQHSAEACRAKAA
>NZ_CP012334.1|WP_066642864.1|2795130_2796108_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
METSKARSVIALAMAALMPAAAWAWEPTKPVEIIVPFSAGGASDQMARTIQGIVAKHELMKQPLIVVNKAGASGAEGLMDAKSASGDPHKLLVASSALYTVPLISKLPFNWRDLSPVAMVAVDEFILWVNAKAPYQTVDQFIAAAKANKLKMGGTSSKREDQMITAMVEHATGAKFIYVPYKGGGEAATQLSGNHIDANVNNPAESVAQWRAGEHRALCVFAEQRLAYTHKVTDTQSWADIPTCKEKGLDVHYEMLRIFLLPGKVAPDQVAYYTDVFKKISETPEWKQYLERSALKPELLTGTALNQYLEKDEAMHKDIIKSAGF
>NZ_CP012334.1|WP_066636295.1|2794456_2794963_-|tripartite-tricarboxylate-transporter-TctB-family-protein
MVEEQERPASRAVVSYMAMELVVAALLAALAVTVIWSNYTIGAGWTDDGPQAGYFPMRIGIIILAATAAVAVQALRKHDRRPFVHVDELRQVCVVLVPLVIYVGLIRFLGIYVSSAIFVAAFMRWVGKYPLWKGLPLAVAIMAVLFWVFEMKFLVPLPKGPLESLIGY
>NZ_CP012334.1|WP_066636292.1|2792841_2794362_-|tricarboxylate-transporter
MQELSALWDGFGVVLSWGNVGLMMVGILLGIVVGVLPGLGGPNGVAILLPLTFSMHPTSAIILLSCIYWGALFGGAITSILFNIPGEAWSVATTFDGYPMAQQGRAGQALTSAFTGSFFGALVGVLLITFLAPAVARFALRFGPAEFFAVYLLTFCSFIGMGRESKPKIVISMGIGFALAAVGMDTVSGDLRMTFGSSELLRGFDFLVAVIGLFGIGEILLTMEEGVAFKGKKAAIDLKVVFKTWASLPRYWLVLLRSAAIGCWLGVTPGGAIAASFMGYGVAKKFAKDPDSFGQGNVEGVLAPETAAHAAGTSALLPMLALGIPGSATAAVLLGGLMIWGLQPGPLLFAEQKEFVWGLIASMYLGNLAGLFVVLSTVPLFAAILRIPFSIVAPMILVVCAIGAYTVHNAAFDIWLMLVFGVVGYLFKKLQYPLAPLVLALVLGDRAEDAFRQTMLISSGSLSVFWSNGLVGSIVALALFALFWPVISMAFSRLRKTRNNLSPRYP
>NZ_CP012334.1|WP_066636288.1|2789686_2792845_-|FAD-binding-oxidoreductase
MTTTPSPVLPQPVRLVPYAAGAAPALATRLRKALRGDVLFDGASRGRYATDASIYQMTPIGIVVPRDQADLATALDIACDEQIPVLARGAGTSQCGQTVAEALVIDTSKWLNQVIDFDPQARTVTVEPGIVLDHLNAWLKPHGLWFPVDVSTSAQCTLGGMAGNNSCGSRSIEYGNMVHNVLSIDAILPDGTQGTFGPVSRLAPEPRLRAILEGVRGIAMRERDEIATRTPKVLRRVAGYNIDIFDCQNPRAYTDDGEANLAHLLVGSEGTLAFTRRLTLKLSPLPAHKVLGVVNFSTFYQSMEAAQHIVRLGPVAVELVDRTMIELAMDNPAFRPVIVRALVGQPQAILLVEFAGDDKQALLQQLRGLTELAADLGLPGAVVEMTEAGPQKALWEVRKAGLNIMMSMKGDGKPVSFIEDCAVPLEHLAEYTRQLTEVFHRHGTEGTWYAHASVGTLHVRPILDMRRDGATRMRAIAEEAAELVRRYKGAYSGEHGDGLCRGEWVSWQYGPRINQAFREIKALFDPANRFNPDKIVNPPRMDDAGNFRFPPAYRVTPYVPALDWSAWDVTRDPMTGQESAPGSAGDPTGGLAKAVEMCNNNGHCREFDAGTMCPSYRVTKDEQHVTRGRANTLRLAISGQVGLDGLASSAVREALDLCVSCKGCRRECPTSVDMAKLKIEARSAWVAAHGLTLRDRVVAFLPRYAPMASRLGALMRWIDRTPALARLVKNSLGVAEQRSLPRLGRSFLADAARDGGRDVAANARARTAPSAAPHVPASASAGAGAAPHAAGRPPAREVLLFVDTFNNYMEPANARAARQVLEAAGYAVHLNLRAGERPLCCGRTFLAAGLVDQAKAEARRLLDTLSPYVERGIPIVGLEPSCLLTLRDEFLNYGYGDAARRLAESAFLFEEFLVREHKAGRLALPLRAPARRLALVHGHCHQKAFDALEPVKTVLGWIPGLEVSVIESSCCGMAGSFGYEAEHFAASKAMAEAALLPAVRAAPPDSWIVADGTSCRHQVLDGTGVESLHVAQVLAAALDPAPLPRQGEDAPA
>NZ_CP012334.1|WP_083229107.1|2803211_2804162_+|DUF2950-domain-containing-protein
MDVQRHGAGKRFIHLCIRLATASVLVFCTATAVHAQKNFSSPDAAMESFGDAVLNNREDALREILGKDFRTLIPPADAGVRQTFRGEWAKAHAVKPTDASRADITVGDAGWTLPIPLVKTDKGWHFDTRAGAEEMRLRRIGRNELAVIQTMLAIYDAQREYAQTEHDGQRVLVYASRLISSPGKHDGLYWPTTANEPPSPLGPAFIDAGVKNAASGGYHGYHFKLLESQGTHAPGGAYAYVVRGKLFGGFAVIAWPAKYGDSGIKSFMVSHAGQVYEEDLGPDTTARAEAIRSFDPGPGWSKVSGDDSRLSGDDGR
>NZ_CP012334.1|WP_083228809.1|2804251_2805250_-|LysR-family-transcriptional-regulator
MLTLRHIEVFHAIMQTGSVTGAARLLNVSQPAVSSVLKHCEARARIKLFERAGGRLRPTPEARALFPDASAIYGRLDAMSRLMQDLAGGRLGSVSLAASFPIANGYLAKAVATFLQERPGIQVALQSLTSPQVIDRVASREVEIGIAYGPVINAEVETEHLVRSAVACVMRDDHPLARLEEIEVGELAPYPIITYLPQALLRGYVDGALNRAGVVPNISVQVSLSLTGMIMAYHGAGIALVEPFLLNSLRLEGLVARPLRPRIELNTLLIRARQSPRSELMDQFVVHLRRELAAMPEMMLSPPAAQDADVALPGIPASARPARHSRKRAKTG
>NZ_CP012334.1|WP_066636318.1|2805343_2806129_+|MBL-fold-metallo-hydrolase
MEIAGYALDLLVVGFPGKSVCHGGMGWSTIALLRGHGRVALIDTGPMGMRKVLIERLRAHGHAPADVTDVLLTHSHHDHTINWVLFPNARIAIGARELAWSLEQPWGETPVPELYMRELASSPRVDRLADGAQALPHLRAHAAPGHTPGHLFFVLEDEDRDVLFVGDAAKTRAELASRRCEATLDSDASAATVERIWSCWSRKPGSIVVPGHDVPLLQRDGRIEYMQRHQAAVKANFGDDPEAFEIIDLTGAISRAGETAR
>NZ_CP012334.1|WP_066642869.1|2806140_2807265_+|Ldh-family-oxidoreductase
MNDSAAQGPGWIRADADTVHAQILSLLLAWGMSDEQARTSAAVMVDTDLSGVDSHGISMLMDYDQSRRKGKLNLHAKPRVVRENAVTALVDADAGLGHAAAVLGMRMAMDRARQQGVGIVTVRNSHHFGAAGYYARMASAEGLLGLCLSSTRTINTVPTRGRVPVLGTNPIAFSAPARRNAPFVLDMATSSAASNKVKVYDLRGNPIPAGWVVDEQGEPVTDASKAMEILFQRPKYIGGGLTPLGGSADMSSHKGYGLAMLVHILAGTLSGSSFSPIRVRTQTATDPDNLGHFFCAIDPAVFRDPGEFEDDMDEVIDTLHATPPTHADEPVLVHGDLEALTRARRKAQGIPLPVTLANKIRALCEEANVPFLFD
>NZ_CP012334.1|WP_066636325.1|2807280_2808228_+|hydroxyacid-dehydrogenase
MKKIYVLDAFHPAGIDWLQGKAEVIPFRDPRGEHWHEDADGIMVRMRPVTAEDFKKARKLKGVVKQGVGVNTLDLDAARKHGIVVANTPGVNSETVAELAFSLALAVARRVVEFDRLIRAGVPIERPKMLGLGLEGKTVGVVGMGNIGVQAASKFHRYGCHIVAYDPYYQPRQDGDAWAAIPHERVQDRGQLWPRLDVLTIHVPYTKETANLVGAKELAALKRNAIVINVSRGGIVNEAALYDALVCGHLFGAGLDVWEEREPPAPEHPLLTLPNVVATPHAAGGTVETQERSSLRVAQELLNILDGGQPASRVA
>NZ_CP012334.1|WP_066636327.1|2808300_2809107_+|aldolase
MSFSLPVNPVKKRMQAGDVALGMSVRMSRSADIARIAKATGHDFIFIDTQHSIFNLETINHIAQTALAIDIAAVVRVKSIHDPDVSLLLDNGVTGIVYPDINTAAEARRAVDVCRFAPVGKRSVSGNFMHFNFQSTPYAQFSTALNDVALLVCMIETPEGLANIEEICAVPGIDVIHMGTGDFAANIGKPGKFDDPEVVAAQARVIEVARRHGKYAGCGGNRDVTRQANAIRHGVQFVTTQTDISFLASAAQQWTSGVREALAAGARS
>NZ_CP012334.1|WP_083228810.1|2809147_2810209_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MSRPARWWLGARGPRYVQDAQEAGVPTRRAALCAAGGFWLAAILCGVPAAQAADAWPTHAIKLVVPFAAGGGVDAVARALAAQLSDELHQSVVVENRVGAGGLIGTDYVAKSDPDGYTLLMGTQTTLAVAPLLSKGATLDPLKAFAGTSLVADSPMLLVANPGFAAKDMKQLIELAKQKPGYVNYGSGGVGTTPHMAGELLALSTGIKMTHVAYKGEQPALTDVVGNQIPLMFSNLVVALPLVQSGRLRALAISTAQRSPAAPAIPTVAESGVPGFDAATWFGVVAPKATPRAVVDKLSDAIHQAVNSPRLRQILQSQGLNVRTSTPAAFDAYMASEFDKWRGVIQQARISTQ
>NZ_CP012334.1|WP_066636332.1|2810230_2811205_+|hypothetical-protein
MHRRHFLQACAAAPLVACGAVRAAGGYPSRPIRFLIGYAAGGTADISLRIVAPILSDRLGQPIVIENKPGAGGIVASQGALTVPADGYTFVLAATGNFGISPVLLKSMPYDAVKDFDMVAQVADFDYVLAAGADSTFKNIKDVVAYAKANPGKLSIGTVQVGSAQFFAAELFKSMAGIQAVTVPYRTSGDVVAAARSGDVQLMVDTIAPVIAQVRGGALRALGVTGDAAFPALPDVPPVSRAGVPGYVVKAWNGLAARTGTPAEATQRIGRELSAILAMDEVKKRYIDLGIIAQYGAPETLRALQLADIRKWGAMMESAHLEKQ
>NZ_CP012334.1|WP_066642871.1|2811261_2812161_+|amidohydrolase-family-protein
MYRAPSASATPMPPRACDCHTHIFGPASRYPYAAERHYTPGEASVRQLLALHDSLGIERVVIVQPSPYGTDNRCTLDAVAALNADGADRARAVVVVDGQTTGQALRAMHAQGARGVRINLETRGANDPAAAGAALREVAGRVADLGWHVQMYTNPLVVVRLADIIDRLPVPVVLDHHAGMRVADPAHQAVRGALIDLIAGGNVYVKLSAPHRASSQPNHADLQPLVDAFLGCRPDRMVWGTDWPHPGAWPGIKRNPATMEPFHPVDDSAALRLARQWISDPAGFAAVLAGNPGRLYAFP
>NZ_CP012334.1|WP_083228811.1|2812387_2812939_+|hypothetical-protein
MPQRSFQFEPGRYVRWAMGMLLILIAISAMAQEAILPSWNEGPSRRAIVSFVQDVTKEGGEHFVPVSERIAVFDNDGTLWSEQPLYFEVMYSLDQVKVMAPRHPEWKTRQPFNLEMLQWVADGSGRRFAGLVHHTDAAREWAYDRDSKIGRLDKALDVARRRDWVVVDMKDEWKRIYSFDAPR

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Crispr_ID: NZ_CP012334_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012334_10

3063175-3063283

Unclear

Consensus_repeat	Method
AGCAAGCCGACTTGTCGGCGCCGCG	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP012334_10

>merge|NZ_CP012334|10|3063175-3063283|CRISPRCasFinder
AGCAAGCCGACTTGTCGGCGCCGCGTGGGGGGCCCCTTTTGTCGCTGGGCCGTCCCAAGACAAAAACGGCCCCCTTTGGGGGCCAGCAAGCCGACTTGTCGGCGCGGCG

>NZ_CP012334|10|10|3063175-3063283|CRISPRCasFinder
AGCAAGCCGACTTGTCGGCGCCGCG	TGGGGGGCCCCTTTTGTCGCTGGGCCGTCCCAAGACAAAAACGGCCCCCTTTGGGGGCC
AGCAAGCCGACTTGTCGGCGCGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012334.1\|WP_066636917.1\|3056156_3057251_-\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|240081
NZ_CP012334.1\|WP_083228845.1\|3059596_3061525_+\|DUF521-domain-containing-protein	unknown	unknown	gnl\|CDD\|377349
NZ_CP012334.1\|WP_066636933.1\|3072155_3072542_-\|reactive-intermediate/imine-deaminase	unknown	unknown	gnl\|CDD\|129116
NZ_CP012334.1\|WP_066636914.1\|3055193_3055565_+\|TraR/DksA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224648
NZ_CP012334.1\|WP_066636910.1\|3050220_3050922_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP012334.1\|WP_076879700.1\|3070020_3072114_-\|ATP-dependent-DNA-helicase-RecG	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236794
NZ_CP012334.1\|WP_066636937.1\|3075622_3076591_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP012334.1\|WP_066642952.1\|3051029_3052226_-\|AI-2E-family-transporter-YdiK	unknown	unknown	gnl\|CDD\|182881
NZ_CP012334.1\|WP_066636931.1\|3069018_3069969_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182999
NZ_CP012334.1\|WP_066636935.1\|3072601_3073522_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176131
NZ_CP012334.1\|WP_083228844.1\|3055586_3056066_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP012334.1\|WP_066642954.1\|3053982_3054717_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|183004
NZ_CP012334.1\|WP_066636923.1\|3061618_3063112_-\|AMP-nucleosidase	unknown	unknown	gnl\|CDD\|236222
NZ_CP012334.1\|WP_066636929.1\|3065635_3069022_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP012334.1\|WP_158515178.1\|3052442_3053867_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|223267
NZ_CP012334.1\|WP_066636920.1\|3058294_3059446_-\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341472
NZ_CP012334.1\|WP_066642982.1\|3075087_3075495_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012334.1\|WP_066642974.1\|3063323_3064451_-\|branched-chain-amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|237959
NZ_CP012334.1\|WP_066642979.1\|3073618_3075013_+\|DUF1446-domain-containing-protein	unknown	unknown	gnl\|CDD\|377804
NZ_CP012334.1\|WP_066636926.1\|3064720_3065308_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369095

Protein	Function_ID	Function_description	E-value
NZ_CP012334.1\|WP_066636917.1\|3056156_3057251_-\|nitronate-monooxygenase	gnl\|CDD\|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	1.00288e-71
NZ_CP012334.1\|WP_083228845.1\|3059596_3061525_+\|DUF521-domain-containing-protein	gnl\|CDD\|377349	pfam04412, DUF521, Protein of unknown function (DUF521). Family of hypothetical proteins.	8.53542e-180
NZ_CP012334.1\|WP_066636933.1\|3072155_3072542_-\|reactive-intermediate/imine-deaminase	gnl\|CDD\|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	2.05635e-51
NZ_CP012334.1\|WP_066636914.1\|3055193_3055565_+\|TraR/DksA-family-transcriptional-regulator	gnl\|CDD\|224648	COG1734, DksA, DnaK suppressor protein [Signal transduction mechanisms].	7.95018e-15
NZ_CP012334.1\|WP_066636910.1\|3050220_3050922_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.35838e-36
NZ_CP012334.1\|WP_076879700.1\|3070020_3072114_-\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NZ_CP012334.1\|WP_066636937.1\|3075622_3076591_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.81882e-126
NZ_CP012334.1\|WP_066642952.1\|3051029_3052226_-\|AI-2E-family-transporter-YdiK	gnl\|CDD\|182881	PRK10983, PRK10983, AI-2E family transporter YdiK.	6.73348e-100
NZ_CP012334.1\|WP_066636931.1\|3069018_3069969_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|182999	PRK11151, PRK11151, DNA-binding transcriptional regulator OxyR; Provisional.	3.1722e-94
NZ_CP012334.1\|WP_066636935.1\|3072601_3073522_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176131	cd08440, PBP2_LTTR_like_4, TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.2616e-65
NZ_CP012334.1\|WP_083228844.1\|3055586_3056066_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	8.67342e-11
NZ_CP012334.1\|WP_066642954.1\|3053982_3054717_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|183004	PRK11161, PRK11161, fumarate/nitrate reduction transcriptional regulator Fnr.	1.80715e-55
NZ_CP012334.1\|WP_066636923.1\|3061618_3063112_-\|AMP-nucleosidase	gnl\|CDD\|236222	PRK08292, PRK08292, AMP nucleosidase; Provisional.	0
NZ_CP012334.1\|WP_066636929.1\|3065635_3069022_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.00749069
NZ_CP012334.1\|WP_158515178.1\|3052442_3053867_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|223267	COG0189, RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis].	5.91244e-09
NZ_CP012334.1\|WP_066636920.1\|3058294_3059446_-\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341472	cd08193, HVD, 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor. 5-hydroxyvalerate dehydrogenase (HVD) is an iron-containing (type III) NAD-dependent alcohol dehydrogenase. It plays a role in the cyclopentanol metabolism biochemical pathway. It catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor. This cyclopentanol (cpn) degradation pathway is present in some bacteria which can use cyclopentanol as sole carbon source. In Comamonas sp. strain NCIMB 9872, this enzyme is encoded by the CpnD gene.	0
NZ_CP012334.1\|WP_066642974.1\|3063323_3064451_-\|branched-chain-amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|237959	PRK15404, PRK15404, high-affinity branched-chain amino acid ABC transporter substrate-binding protein.	0
NZ_CP012334.1\|WP_066642979.1\|3073618_3075013_+\|DUF1446-domain-containing-protein	gnl\|CDD\|377804	pfam07287, AtuA, Acyclic terpene utilisation family protein AtuA. This family consists of several bacterial and plant proteins of around 400 residues in length. One member of this family has been characterized in Pseudomonas citronellolis as AtuA, a member of a gene cluster that is essential for the acyclic terpene utilisation (Atu) pathway.	4.21243e-165
NZ_CP012334.1\|WP_066636926.1\|3064720_3065308_+\|alpha/beta-hydrolase	gnl\|CDD\|369095	pfam06821, Ser_hydrolase, Serine hydrolase. Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile. This family has an alpha-beta hydrolase fold. Eukaryotic members of this family have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic members of this family.	3.7424e-65

>NZ_CP012334.1|WP_066636923.1|3061618_3063112_-|AMP-nucleosidase
MSSGDAVPPTVRPDFMPYEAFDSAEAAVTRLIEIYERNTAYLRAGLQRITHGDEMQGVRVRACYPSVRIAVHTYDPVDSRLSYGHVAEPGVYQTTITQPGLFKDYLLEQIGHLLLNHKVPVEVGESHVPIPLHFAFPNGAYIEGEHLEGLKRPLRDIFDVPDLAITDDAIVNGTWHGRSNEPRPLGPFTAPRVDYSLHRLQHYTATAPAHFQNYVLFTNYQFYVDEFCARARAMLAAGEGDYDALIEPGNRVTRRGEPIAADAAPGRLPQMPAYHLTRADHSGITLVNIGVGPSNAKTITDHIAVLRPHAWLMLGHCAGLRTSQRLGDYVLAHGYVRDDHVLDADLPTWVPVPPLAEVQVALEQAVEEVAGLSGWDLKRIMRTGTVATIDNRNWELRDHTEPVQRFAQSRAIALDMESATIAANGFRFRVPYGTLLCVSDKPLHGELKLPGMATAFYRRQVGQHLEIGIRALERLREMPPERLHSRKLRSFMETAFQ
>NZ_CP012334.1|WP_083228845.1|3059596_3061525_+|DUF521-domain-containing-protein
MIALSDYDQALLQGDRGAAAALAMRVLVRSAAVMGADSLIDIESAHIDGCLYHGQASLDFVERLVQGGGKVVVPTTLNVGSMDLIHPELFRGDDALRSAGTRLMQAHVELGCESTFTCAPYQLARRPRLGQQIAWAESNAIVFANSVLGARTNRYGDFMDLCAALTGRAPRCGLHLPENRRAGIVFALGDDFPRDPASRDIWYAALGLLIGQRAGGAVPAVTGLPADTTEDELKALGAAAASSGAIALFHAVGITPEAPTLEAALAGGPTARTIAVGREDLRDVRAMLNQAAPGAPLAAVSVGTPHFSLAECAALEALLADSADRFAVDFYVNTSRYILWELEASGRADRLRAAGVQFVTDTCTYITPIMRQTQGLVMTNSGKWAHYAPANIGVQVAYGSLRECVRSARQGKVCFDEADVPCTASPMATGDGHDAVDSAIGTAIGSAIGSAIDSGIDSAIDSATDSAIGAAPGGATGAGVAAARGVARAAAGPVSSASCSGIAIVPGIGAGGLLVLDEPLSFWGGYDAQAGTIVEPRHPQFGLALRGTFLLMARAKGSSSSSSVLAEAIRNGTGPAAIVMRERDLIVALGCIVASELYGVDVPIAVVDEAGWQALAALPPGTPLRLEAGEARCDITAGTLPS
>NZ_CP012334.1|WP_066636920.1|3058294_3059446_-|iron-containing-alcohol-dehydrogenase
MQSFAFHAAKSVIVAPGSAGQLADHVTRLGARSVLVVTDPGVARAGLVEPVLQALRGAGLSVSCFADVEPEPPVAVVLRAADQARASGAECVVGFGGGSSLDAAKLAALLAAGDSRLEDIYGVDKVRGGRLPLILVPTTAGTGSEVTPIAIVTTGENMKQGVVSPVLLPDVALLDADLTLGLPAPVTAATGIDAMVHAIEAYTSKRLKNPLSDSLAREALRLLSANIRRACRTPSDREARQAMLVGACMAGMAFANAPVAAVHALAYPVGARFHVPHGLSNSLVLGPVLRFNLPAALPLYAELAEQVLPHAAGSPEARAAALIETLEALPADLGLPARLSQVGIGPADIGLLADDAMRQTRLLVNNPREVSHADAAALYRQAL
>NZ_CP012334.1|WP_066636917.1|3056156_3057251_-|nitronate-monooxygenase
MPARIRTPLTERLGISTPIIQAPMAGVTTPALAAASANAGALGFLGVGAMTAPVARKAIADTRALTQRPFGVNVFCHRPAVANAAVEAAWLSYLAPAFREFGAEPPTALGEIYKTFVNDDAMLDVFLETRPAVVGFHFGLPDASRIRALRDAGIYLMASATSVEEALRIQDAGIDAIVAQGYEAGGHRGVFDPEARDERLGTFALTRLLARRVDVPVVAAGGIMDGAGIAAVLALGAQAAQLGTAFVGCPESSADAAFRAALTDTRAVTAMTAAISGRRARGLYNRLMQLGEAHDSPAVPDYPIAYDAGKALNAAAKARGNSDFAAQWAGQAVRLSRALPAGELVAVLDTELQEALRGLGALAA
>NZ_CP012334.1|WP_083228844.1|3055586_3056066_+|MarR-family-transcriptional-regulator
MSRSPLPRLAPQLPRRSDAGTSRHLREADFVALARLRFALRQFTAFSESAAAERGLTPQQHQALLAIKAAPGETMTVGEIADWLLLRPHSAGELINRLERMDMVQRQSDAVDRRKVHVGLTQAAQDKLDALSAAHFEELRAIGPMLRDLLGHFDSNGSE
>NZ_CP012334.1|WP_066636914.1|3055193_3055565_+|TraR/DksA-family-transcriptional-regulator
MSHLSAAELGALAQRLRDIRARALQEAHGGGDPGKDDADARQEPGDPADIAEPRRQEEVRWAEMEIDRHTVANVDRALARLAQGEYGICIDCQGAIPQARLFALPTAIRCAACQAVAEASGRA
>NZ_CP012334.1|WP_066642954.1|3053982_3054717_-|helix-turn-helix-domain-containing-protein
MTGLTPSQDARVSSAAPARVPCEGCGARRLCQAAQLCRGGDDRPVSLPVCARKVKAGEAVYRAGDPLRNLYTSRAGTSKSIRLYRDGRQQITGFQLGGEFLGMDAIATGRHQTEAIALEDMVVCVLPYREIEALADAYTDVRRGMERMLSQEIVREAGLLMLMGNLSAEERVAAFLVDLSDRYAERGYSALAFTLRMSREEIGSHLGMKLETVSRMFSRLQQRGLIALHGKDVRILDLPALRLV
>NZ_CP012334.1|WP_158515178.1|3052442_3053867_-|tetratricopeptide-repeat-protein
MPTPAISDAVPTFAGEQWLALGRALHKAGQHAEAVKALQRAAAQLPLDLDVYRALVDALDASGQVADAASARIGIDAIERRRAVDLFEIGRVYARHRQWDAAGHWLERALIIDPGLLAAHICMAWVLRQLGRQTEHSRHVHRVYRRQAAFIQAKSSARRRTVLILCSSGYANVPFRHLLPPALNRVVRWVVDLGVVGIAHARSRGLPPHDIAFNVVGDADLGAACRETLARFAATARTPLLNRPDRIERTTRERIGALLDGIAGIHVPATVRWDRAHGPAAAVHAAIAARGLDYPVIVRPVGGHGGQDVVLLDSPVDGSTLPSMGEMYMTAYRDYRSADGYYRKYRVIFIDREPYPYHLAIGSQWLLHYFSADMLSGAWKLEKERRFLDDPEHVLGARAWAALRAIGARMDLDYCGIDFALLPDGRVLVFETNATMLVHPEVEEDGLRFKNAYIQNILDAFHGLMTRRIRVHSS
>NZ_CP012334.1|WP_066642952.1|3051029_3052226_-|AI-2E-family-transporter-YdiK
MGPSDRGDAVRLFFLIVVLSILMGGSLYILRPFIPGLIWATTIVAASWPLLLIVQRRLGNRRWLAVTVMMAGLVVVIVLPLYQTIATLADQANRITAAIRNLPTYALLPPPHWVHDIPLVGHRMSTEWQRLSDAGPGGLLARMEPYLTAGVRWMMANVAVLGQFLIHMLVTLIFSGILYARGEAAAAFVTRLAVRLAGPAGEGAIRLAGQAVRAVALGVVLTAVVQAALGGVGLWVAGVPAAGILTAVMLLLCVAQIGPLLPMAVGVIWLYRLDANVAATLLLLWSLFIGTMDNVMRPFLISRGVQLPLLLILCGVVGGLLALGPAGLFIGPVILAITQVMLRSWVDGGALAQDIPAPSPVVEPTHTPAADTASLEGMEAMQVARAAPERHGEPSALP
>NZ_CP012334.1|WP_066636910.1|3050220_3050922_+|GntR-family-transcriptional-regulator
MSLTEILSTLRLDRSRHAAPQVFEKLRELIVSLELAPGTVLSRPELAEAFGLSQTPIRDALLRLSEEGLVDIFPQHTTEVSRIDIAAARQAHFLRRSLELEIVHILAGRADALLAARLQAHIDLQRASLAANEYAAFIAADQAFHREMHEAAGVSGLWELEQRYSGHVDRLRRLHLPEAGKAERILQDHQRVLDAIVAQDAPRAQQALREHLSGTLSQVEDICKRYPDYVRAA
>NZ_CP012334.1|WP_066642974.1|3063323_3064451_-|branched-chain-amino-acid-ABC-transporter-substrate-binding-protein
MKKHHRLAAMAALALTAGMLATPAQAQAIAIKIAVVGPTTGAVTQYGDMVREGVHTAIEQVNAAGGVNGRKLEAVVIDDGCEPKQGPTAANRVVNEKIGFVVGGVCSGATIAAAPIYEQEGVVMVTPSATAPALTDGKKYNFIFRTIGRDDQQGPAAAAYIVDKIKPKKVAVLHDKQSYGQGIATSVKNQLEKAGIPVAVFEGINAGDSDYSAVITKLKSANVDFVYYGGYHPELGLLMRQGAEQGLKARFMGPEGAGNPDINAIAGQAVEGMLLTLPADFSQDPKNTELVKAFKDKQRNPSGAFQLTAYTATMAIVDGIKGVGAADPTKVAAWLHKNSIESPIGKVSWNSQGDLNSFAFKVYEWHQDGSHTPAP
>NZ_CP012334.1|WP_066636926.1|3064720_3065308_+|alpha/beta-hydrolase
MRFQPIIVPGWRNSGPDHWQTLWQHSLPHAVRVSQRDWENPNPDDWIGAVAACVEAAPWPALLIAHSLGCIASVALPTALHGRVAGALLVAPADIERPGAAPGLASFGPIPTRSLGFQSVVVASDNDPCCALPRARDFAHHWGSRIVVLSGAGHINAAAGFGDWPDGLKILRALRRRAAWRVSAPMRRIPAIARA
>NZ_CP012334.1|WP_066636929.1|3065635_3069022_+|hypothetical-protein
MAKRIHKWPGGTHAASRAPFTLLRGEHQARVNKAARCRDRIAEASRHLQANTGRAPDAGDLAALERSEAKLQDQTKVHASLRDVLVDQTIRAYLPENTGRRQAKQRYKGLIKLRQGPLNKPHRAGSAPDAVRCALDTATALEASARQVQAIGQAYQAGDGRIVLSGQMVDELVSLLNGMKMLRPQEQDPADFLYPAVKLMHEANRGAAPGDPLLPKLLRDLGNAGRDDAQGLRAQLMRKCDALDFWLAHHAEESYAHAPAATRQGLAAALDVLLDGLAGAARKVLHEELQACVPGWARQAQAGLFRDAGILHDSAQRWRDHGLAHGDGVAVLQASPAEAVKMLLEQAANEALGTAAAPAGERAPLIHGLRSRLDPLAQVIQRALDEKGLANHATPNEIAALRQSLMQAVLEETGILGEIHRLRAADIPTAASPSQGATPAVGSRQAQPRRAPHPGNLRTASDPFGAPNRPLHSQVLKRMKNAGADAQRQIIKMLTACRQSGDKSLSGHKLRALNGAYAALQAVHGNAAQGVWQALLKDETMRLKDRDLQALNSGVLCARAGGAANPGSVVADDAERAASDRLLDEIWTAVRATSARRSATPLLKSWCASPSATADTVSGPALARQTEVLRDRIGMLEDGKVDVRTLLDAALEELDNRELKALIAALARAPAADSATRATSIRTVDVAATLPFTSRAASGARSAADATTMPAASATAMSAITSAAAAALDAPATQPIDAGTSTLRRRLARLLRGGDRRPSVQAQPAATAPAPAPMNTQVFVDQLYAAARGQAEKRMEALRDTLMPPFLTTLFAQAGVLHAMIDTPEARAVNGPPAKTLERLIRDAVRQGKLTHQSNADTAAALTGTYFLRTTRGYDIVRDLTRTLANETASLHARLAAGMEDLGIAHFCSARAAAEWRDGAIEHILHKTGIWERLDLAVARRAPRIMATQRDAPGLAGIDGRPSLMRGEVRASTRSTQSVDRNGYAIFGALPGRAGMESVPEEAGHAAIDRRVDEPIYATIDQPVDAPIYAAIDQPTDGPADAAIGRHIDEPPYAGVQKRASTVASDDSGIGSADDASQISINGHPYEATRGSAYTTPRTRMANAVDPQLAAALRAALEERNRGAWNRA
>NZ_CP012334.1|WP_066636931.1|3069018_3069969_-|LysR-family-transcriptional-regulator
MTLTELKYIVAVARERHFGRAAEACFVSQPTLSVAIRKLEDELGVTIFERGGAEVGVTPIGQRIVAQAQKVLEESASIKEIARQGHDPLAGPLRVGVIHTIGPYLLPRLVPVQIERTPQMPLLLQENFTLRLVELLRQGEIDCAIMALPLPEAGLVIQPLYDEPFLVAVPRDHPWADRTAIPAQDLKQQTMLLLGSGHCFRDQVLEVCPELSRFSAASDGIQRTFEGSSLETIRHMVAAGIGITVLPVTAVPENPPADSLLRYVPLEEPVPDRRVVLAWRRSFPRLAAIEALAQAVYATPMPGVRMLEGLAAAHQD
>NZ_CP012334.1|WP_076879700.1|3070020_3072114_-|ATP-dependent-DNA-helicase-RecG
MPAATAPGKARASAAQAASPPRGDAITRRLHALGLVEPADLILHLPLRYEDETRITPIATLRPGFAAQVEGEITRCEVQYRPRRQLTAAIADDSGELQLRWLNFYPSQQRQLAVGRRLRARGEIRGGLFGREMVHPRMASADAPLATALTPVYPTTEGLHQTVLRKAIGQALAQADLADTLPPAVRERYGLAPFDESIRILHAPPPGVSEHELVERAHPAWRRIKFDELLAQQLSLAAARAARRSHKALPLAPSGNAGGLVARLYGALPFALTGAQQRVVAEIAADLARPFPMHRLLQGDVGSGKTVVAAIAAAQAMEAGAQVALMAPTEILAEQHFRKLVDWLQPLGVRVAWLSGSVGAKARREAAAAVADGSVQLIVGTQALIQEHVAFQRLGLSIVDEQHRFGVGQRLALNRKGESARGRIVPHQLNMSATPIPRTLAMTFFADLDVSVIDELPPGRTPVVTKLVSDARREEVIAHIAQAARAGRQAYWVCPLVEESEALELQTAVDTYEAMRADLPDLRIGLVHGRLPQNEKAEVMQAFREGRVDVLVATTVIEVGVDVPNASLMVIEHAERFGLAQLHQLRGRVGRGTAESVCVLVYQAPLSRIARERLRAMFETSDGFEIARRDLVQRGPGEFLGTRQSGLALLRFADIELDAAIAEQAREAAAWLRKDHADAVQAHLARWMRGREDFLRT
>NZ_CP012334.1|WP_066636933.1|3072155_3072542_-|reactive-intermediate/imine-deaminase
MNKEIIHTQDAPKAVGPYSQAVAVTGARTVYLSGQIGLEPHNGELVSESFEGQVKQAFANMLAVAEAAGGTKENVVKLTLFLTDLGKFGTVNTIMADIFPQPYPARSTVGVASLPKGAQFEVEAVVVL
>NZ_CP012334.1|WP_066636935.1|3072601_3073522_-|LysR-family-transcriptional-regulator
MNLSARHLRAFVALAEERHFTRAAQRCHLTQPAFSALIRAIEDDAGMRLFDRTTRHVELTAEGRILETSARRLLADFELVMEDLRDHAARRRGRVALAALPSLAAGWLPDILADFHRRYPGIALTLRDALLDPCLDMVRDGEVDFAVASRRADMAELDSEFLHADRFHLVCRADHPLAARPAATLAQVAKWPLIQLARNSSVRQHLDAALGRRKLRPLVEVEHLATVTGLVAAGLGVSIVPEMTLFHFQRPGVAIRPLAGKVPTRALYLVKRTGRTLPLAAQTLYETLLREREHIASIAHHAGLSR
>NZ_CP012334.1|WP_066642979.1|3073618_3075013_+|DUF1446-domain-containing-protein
MPSPSPAAPPAAASTLLIGCASGFSGDRTDGAGPVVDTLAARGGGTLIFETLAERTLALAQLARQQDTRAGYEPLLDELVGPVLARCHAHGIRIVSNFGAANPPGAARRIAELARAQGLPAPRIAIVHGDDLSSPAQRALLREQLGPRMDDMDIVSANAYLGGTEIADALRAGADIVVAGRVADPSLTVGPALAHFGWREDDWEKLGRATMAGHMLECGTQVTGGYFCVPGLKDVDGLHETGFPIAEISANGDFVIGKAAHTGGRVDARTVKEQLLYEVHDPARYLTPDVVADLSRAQVMELGADRVQLRGITGHARPDTLKVNVCHRGGWLAEAEISYAGVQAEARARLAAEIVRRRLQDALRLRIDLVGAVSILDNDDGALRAALPDRHARDVRLRVAGAHADRAVAERVLREVTALYCCGPAGGGGVRTALRPRLNMVSCTIDRGAVRGGWRMYDPAEDEQ
>NZ_CP012334.1|WP_066642982.1|3075087_3075495_+|hypothetical-protein
MNRSLVPLYRLAHSRSGDKGDISNLSLIAWDPACYDVIAAYVTAERVREWFAYRRPHAVTRYLLPTLHAMNFVLEGVLDGGVNDALNLDAHGKSLSFQLLDLPVPVPAEMAARLPDVPGDPWPFQSLARDGSTGG
>NZ_CP012334.1|WP_066636937.1|3075622_3076591_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MKIRTLPALAAVIAAGCAPLAASADDFPSRPVTFVVPFAAGSATDQIARALAQGVTEQTGQAVVIEDKPGASAMIGAQDVARAKPDGYRVLITTNTTHAANEHLYKHLQYDPVKDFAPLTLLGKGSQIMVVNPSFPAKTVGEFLAMARKEPGKLSFGSGSSSSRIAGELLQQMANVKLLHVPYKSNPLAVTDLLGGQISTMITDMATGLPQVQAGKLRALGVTTLKRSPLAPDVPTIAESGVPGYEMGYWFAAYAPAGTPADVVKRLNALLVKATEGPAAKQFYASTGTDPATSTPAELATFQKAESKKWQTIIKQAGIEPE

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Crispr_ID: NZ_CP012334_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012334_11

3948433-3948524

Orphan

Consensus_repeat	Method
CCGCGCTTCCCCCTCAAGGGGGCGACGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012334_11

>merge|NZ_CP012334|11|3948433-3948524|CRISPRCasFinder
CCGCGCTTCCCCCTCAAGGGGGCGACGCACGTGGACCGGAGGGAAGGCTCACCCCGAAGCGCTCCCGCGCTTCCCCCTCAAGGGGCGACGCC

>NZ_CP012334|11|11|3948433-3948524|CRISPRCasFinder
CCGCGCTTCCCCCTCAAGGGGGCGACGC	ACGTGGACCGGAGGGAAGGCTCACCCCGAAGCGCTC
CCGCGCTTCCCCCTCAAGGGGCGACGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012334.1\|WP_066643261.1\|3952107_3953523_+\|L-seryl-tRNA(Sec)-selenium-transferase	unknown	unknown	gnl\|CDD\|235278
NZ_CP012334.1\|WP_066638942.1\|3959363_3960161_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP012334.1\|WP_066638922.1\|3943954_3944914_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP012334.1\|WP_066643259.1\|3944926_3945532_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227105
NZ_CP012334.1\|WP_158515188.1\|3957267_3958266_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP012334.1\|WP_066638904.1\|3934213_3935002_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224098
NZ_CP012334.1\|WP_083228912.1\|3940112_3942638_+\|mechanosensitive-ion-channel-family-protein	unknown	unknown	gnl\|CDD\|225803
NZ_CP012334.1\|WP_066638937.1\|3954591_3956013_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP012334.1\|WP_066638935.1\|3954012_3954468_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP012334.1\|WP_083228910.1\|3936107_3937520_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_CP012334.1\|WP_066638939.1\|3958295_3959084_-\|class-II-aldolase/adducin-family-protein	unknown	unknown	gnl\|CDD\|235916
NZ_CP012334.1\|WP_066638925.1\|3945811_3948397_+\|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase	unknown	unknown	gnl\|CDD\|236424
NZ_CP012334.1\|WP_083228909.1\|3934998_3936111_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224097
NZ_CP012334.1\|WP_066638933.1\|3953569_3953890_-\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|224987
NZ_CP012334.1\|WP_083229130.1\|3951194_3952079_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176113
NZ_CP012334.1\|WP_083228913.1\|3956326_3957223_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238636
NZ_CP012334.1\|WP_066638916.1\|3938797_3939859_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270307
NZ_CP012334.1\|WP_158515187.1\|3937303_3938698_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153238
NZ_CP012334.1\|WP_066638928.1\|3948849_3951087_+\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|273805
NZ_CP012334.1\|WP_145925441.1\|3942707_3943655_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296

Protein	Function_ID	Function_description	E-value
NZ_CP012334.1\|WP_066643261.1\|3952107_3953523_+\|L-seryl-tRNA(Sec)-selenium-transferase	gnl\|CDD\|235278	PRK04311, PRK04311, selenocysteine synthase; Provisional.	0
NZ_CP012334.1\|WP_066638942.1\|3959363_3960161_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.84918e-45
NZ_CP012334.1\|WP_066638922.1\|3943954_3944914_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	4.03023e-42
NZ_CP012334.1\|WP_066643259.1\|3944926_3945532_-\|hypothetical-protein	gnl\|CDD\|227105	COG4764, COG4764, Uncharacterized protein conserved in bacteria [Function unknown].	3.61839e-81
NZ_CP012334.1\|WP_158515188.1\|3957267_3958266_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	4.76783e-115
NZ_CP012334.1\|WP_066638904.1\|3934213_3935002_-\|ABC-transporter-permease	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	1.60702e-57
NZ_CP012334.1\|WP_083228912.1\|3940112_3942638_+\|mechanosensitive-ion-channel-family-protein	gnl\|CDD\|225803	COG3264, COG3264, Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane].	5.30748e-112
NZ_CP012334.1\|WP_066638937.1\|3954591_3956013_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	9.56912e-131
NZ_CP012334.1\|WP_066638935.1\|3954012_3954468_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	1.86708e-27
NZ_CP012334.1\|WP_083228910.1\|3936107_3937520_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	3.6869e-156
NZ_CP012334.1\|WP_066638939.1\|3958295_3959084_-\|class-II-aldolase/adducin-family-protein	gnl\|CDD\|235916	PRK07044, PRK07044, aldolase II superfamily protein; Provisional.	2.10637e-132
NZ_CP012334.1\|WP_066638925.1\|3945811_3948397_+\|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase	gnl\|CDD\|236424	PRK09238, PRK09238, bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated.	0
NZ_CP012334.1\|WP_083228909.1\|3934998_3936111_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	4.48668e-76
NZ_CP012334.1\|WP_066638933.1\|3953569_3953890_-\|multidrug-efflux-SMR-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	6.92688e-27
NZ_CP012334.1\|WP_083229130.1\|3951194_3952079_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176113	cd08421, PBP2_LTTR_like_1, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	8.83014e-55
NZ_CP012334.1\|WP_083228913.1\|3956326_3957223_-\|amidohydrolase-family-protein	gnl\|CDD\|238636	cd01311, PDC_hydrolase, 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most important intermediate metabolites in the bacterial pathways for various phenolic compounds, including lignin, which is the most abundant aromatic material in nature.	5.0764e-65
NZ_CP012334.1\|WP_066638916.1\|3938797_3939859_-\|extracellular-solute-binding-protein	gnl\|CDD\|270307	cd13589, PBP2_polyamine_RpCGA009, The periplasmic-binding component of an uncharacterized ABC transport system from Rhodopseudomonas palustris CGA009 and related proteins; contains the type 2 periplasmic-binding fold. This group represents the periplasmic binding domain that serves as the primary high-affinity receptor of an uncharacterized ABC-type polyamine transporter from Rhodopseudomonas palustris Cga009 and related proteins from other bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, and plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.02742e-57
NZ_CP012334.1\|WP_158515187.1\|3937303_3938698_-\|hypothetical-protein	gnl\|CDD\|153238	cd03144, GATase1_ScBLP_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP). Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP). Biotin-apoprotein ligase modifies proteins by covalently attaching biotin. ScBLP is known to biotinylate acety-CoA carboxylase and pyruvate carboxylase. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, the Cys residue found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow in a typical GATase1 domain is conserved.	1.62155e-06
NZ_CP012334.1\|WP_066638928.1\|3948849_3951087_+\|TonB-dependent-siderophore-receptor	gnl\|CDD\|273805	TIGR01783, Ferrienterobactin_receptor, TonB-dependent siderophore receptor. This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	9.00614e-118
NZ_CP012334.1\|WP_145925441.1\|3942707_3943655_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	1.76395e-146

>NZ_CP012334.1|WP_066638925.1|3945811_3948397_+|bifunctional-aconitate-hydratase-2/2-methylisocitrate-dehydratase
MLATYRQHVAERAALGVPPLPLSAQQTADLIELLKAPPKGEEAFLLELITHRVPAGVDDAAKVKASYLAAVALGKESCPLIDRAKATELLGTMLGGYNIGALVELLDDAQVGPIAANGLKTTLLMFDAFHDVKEKADKGNANAKAVLQSWADAEWFTSRPEVPKSLTVTVFKVTGETNTDDLSPAPDAWSRPDIPLHAQAMLKNARPGIEPDEPGKVGPVKFLNQLKEKGNLVAYVGDVVGTGSSRKSATNSVLWFTGEDIPYVPNKRFGGVCLGSKIAPIFYNTMEDAGALPIELDVSQMNMGDVVELRPYEGKALKDGKVIAEFQVKSDVLFDEVRAGGRIPLIIGRGLTTKAREALGLAPSTLFRLPVSPADTGKGYTLAQKMVGRACGLAEGTGVRPGTYCEPRMSAVGSQDTTGTMTRDELKDLACLGFSADLVMQSFCHTAAYPKPVDVKTHHTLPQFMSTRGGISLKPGDGVIHSWLNRMLLPDTVGTGGDSHTRFPIGISFPAGSGLVAFAAATGVMPLDMPESVLVRFKGKMQPGVTLRDLVNAIPLYAIKQGLLTVEKQNKKNVFSGRILEIEGLPDLKCEQAFELSDASAERSAAACTVRLNKEPIIEYINSNIVMLKWLIANGYEDERSIRRRIQAMEAWLANPQLLQPDADAEYAAVIDIDLAEIKEPIVACPNDPDDVKTLSDVAGAKIDEVFIGSCMTNIGHFRAASKLLEGKRDIPVKLWVAPPTKMDARQLTEEGHYGTFGAAGARTEMPGCSLCMGNQAQVREGATVMSTSTRNFPNRLGKNTNVYLGSAELAAICSKLGRIPTREEYMTDIGVVNENGDKIYQYLNFDKIDDYKDVADVVEV
>NZ_CP012334.1|WP_066643259.1|3944926_3945532_-|hypothetical-protein
MRPAALAALVFPLVWLSGCATAPPRNPEDICAIFREKDDWYEAALDIQKKWGVPVQVPFAILFQESGFRYDAKPPRDYLLGFIPWGRVSSAYGYAQAKDETWDDYVSQNHRWFASRDDFDDAMDFMGWYIDKTQKLNGVSKLDAYGQYLNYHEGWGGYRARSYNRKPWLIGVARKVQARADRFRQQYAGCKDELDSGFWPF
>NZ_CP012334.1|WP_066638922.1|3943954_3944914_+|LysR-family-transcriptional-regulator
MEFRQIQYFICLFEEGTVTRAARRLNIVQPALSMQIARLEEELGRKLFERSQQGMQPTAAARQMYRLFLPILRDYTHAREQVLRTDGELNGHVNVGMIASVAQGVLSDALAAFNARHPKVTVTVTDGYSATLADLVAGGQLDAAFINKPRRPLSLSVEHIADEDVVLVTGTGHAHGLGPTLSFREAAALDLALPTRQHGLRGILESFARTEDVDLSPQFEMDSIVSIIKLVERTRYATLLPRVAIRNRVRRGRLNCHEVVSPRLIRQIACVTHPRRALSAEATAFVGVLADHVRGLAEDADTPAASRNDATAEASPPRG
>NZ_CP012334.1|WP_145925441.1|3942707_3943655_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MLALTVVLCAPGGAWAGQYPDKPIHIVVPYPPGGFNDTLGRLVGAKLSAAWGQPVIVENRPGAGTIVGTSTVAKAPADGYTLLVAQFPFASNPSVYRSLPYDTGKDFAPIVLAGQSPMLLTVRKDSSIKTVRDLVQAAKKSPAAINYGSSGTGSSNHLAMALFERMAGIHMVQIPYKGSSPMMTDLAGGQVEAAFDAIANCWAFVQSGKVRPIAVADTRRTPLLPDLPTVSEAGVPGYDVSSWHGFVAPAGTPPEILDKLNTQINAILRMDDVRETFKAQGVVPAGGSRADFSRFIGQQMTKWRQVVAEAGIPPQ
>NZ_CP012334.1|WP_083228912.1|3940112_3942638_+|mechanosensitive-ion-channel-family-protein
MRFPAFFPSAALRRPAIASRPQHYPARPSAPSAFRTLATRLLLSLFLALAVAPMWSHAQTSTPQQEIDKSLDAARKEMEALRKNLAEQTDDAELLRRRAAAMDIQSKADAIAEKLTPILASVQARLTELGPASDTGKEARDIAAQRADLEKSRSTLDAQIKLARLLSVEGVQTAELVSTMRRSQFQARLGERRPSMLGTQFRDDFEEDLPRDLSRFDSLRDELAAALRGTPGWVWAVLLALAAAVIGMSAAVARVVRRFTASRVPAGRLRRSFHALIVVLVATLAPGLIGQLLYIGLDWQGQLPDATQALISGFAGMLCMGGYVTGLGLALISPSRPSWRLPDIPDAIAEKMRWFPHTLGPLIVVVWLLDRLPVSLNASLSTAISVNCLVTFLLVALMATALVRLERTRRKVLRDPETGHAPPRPLWMLITVSTAWVVMAVGLIAVLTGYVAFGNFAAKQLVWTLIVLSSAYLLTVLTDDFFMSVLGSSRRDADGHEHGPEPRIRDQAAVVLSGVTRVLIGLVAFVMVLGQFAEGPVELLQRAEQLLNGLAIGHVELRPAALVQGFLVLAASLLGVRLLKRWLINRYLPTTTLDPGMQTSATTLFGYIGVAVAVGLSLSAVGIGLERVAWVASALSVGIGFGLQAVVQNFVSGLILLAERPVKVGDWVSLGGVEGDIRRINVRATEIQMSDRSTVIVPNSEFITKTVRNVTHANPLGLVQIKLPMPLATDATKTREIILSAFREHEDILDTPAPNVFLDGIDAGNLMFNATGYVGSPRQAYGTRSALLFEVLQRLAEANIGLGKPPTMLVAAPAPLLPGIAASAEPLAPAPPDPSRTADTE
>NZ_CP012334.1|WP_066638916.1|3938797_3939859_-|extracellular-solute-binding-protein
MQRREFLKKSAVTAMGMSAAGRLSLAAAQSSGTLAMMTWGGLWGNGMAQYVDAPFAKSTGYTITQDRGPTPVERVTKLKINLGNQPYDLVQLHDGVVPLAESQGVLEPLDPASPNLSFLKQIPDRFKRPGWVAMIYSALGIVYNPKEVKNPPRGYADLWRPEFQGRIVLPEITHSIGPYIIPIGAMAAGKDPKDEKAGFDMLRKMVKLEPIWAKDTDTIMSSLQTGEAVVGLLYKSQTYTVREKGGQAEWVFPAEGAISYVAGTGIAKGTKHKALAEQYINMTLNPEYQTWVAKVFNYAGSNPAMIKLLSPELQQRVQFSDAEVSRIIDLDQAFISARRGDWTDQWNRVISGA
>NZ_CP012334.1|WP_158515187.1|3937303_3938698_-|hypothetical-protein
MARGHALRLTPDGYAGPDTLARAARHAGLPAAAVSGPGAPAAQDERPIALPRIVLYCGAAIGYPYYAYYSHCLWSLGLPYRRATAADIAGGILDHADVLILPGGFATWGLDRIEGQTGVDDAIRAFLARGGAGIGSCGGAYYFSQGRPHWLGLLDAKPRYTHEYLCTGAGLLNVRLADAALRRDLPETMELAYYHGPVYEPGHRRARTGGTFESHIMSTRLFIDNPLEGERFDRVMRDRVAILSSNAHEGRVVGFSPHPEMGEFLRKAMALDGYVRKYLPIRGRKTMEETLRFYAREDCLSFRLVLNAALMLGAFDVRGDRGAVDLGRQHQESAALRSGGTAAPAPACSPDENLRRAEQSWHVAANALAGRLDNEEPALSELMGGMLHTLADEWKELLLAPELRDGDDEALSAELCLVMDDAILALQGAPRRAVEMLVLLELPVRLLAAAVRIARFDRVIKESM
>NZ_CP012334.1|WP_083228910.1|3936107_3937520_-|ABC-transporter-ATP-binding-protein
MERTAAGARTARRGRRGVVGRAVPGDGRCHPRPAGRAAPCRGDAGSVGASRAPAGGGGTYCAVRPRHQGVDVSVVASAVVDGPARTADAAALDVRFDGVEKRFGPTVALHRLDLDIERGTFFSLLGPSGCGKTTTLRLIAGFEQPSRGDIHIRGKRVTGVPAHKRNFGMVFQSFALFPHLTVAENVAFGLKMRRVDTASIARRVAGALDMVALGGFGQRYPRQLSGGQQQRVALARAIVFEPDVLLLDEPLSALDKLLREQMQVELRQLQRRLGTTTVFVTHDQEEALTMSDRVAVMKDGRIQQAGAPRDIYERPGTEFVATFLGASNILHGEIRGREGDKLVVGLGGTCLTVDAPAGTGTASGSHAVGDAIKLALRPEKVRLDPQGRLAATLKEVVYRGAQTHLFMESEGGALAAHLPNDGVRAMHLAPGAVVRLAWDDAAVVALAPTPAAPGTQTPTAGSRGDGRARP
>NZ_CP012334.1|WP_083228909.1|3934998_3936111_-|ABC-transporter-permease-subunit
MSGPARPPEGRAPSLGEAVAQRQEGTSSGAPARPPEGRAPSLGEAVAQRQEGTSSGAPARPREGRAPSLGEEVAQRQDDTPRNRALLSRTGLLWAVATPPVLLLLVFFVLPLAYLFFVSFMTNSQTALYDLAPTLRNYVEVATDPFYLLIIQRTLLATGVVLIACLLLGYPVALYASRLPPRGRMIMLLLMMFPLMVSNVVRAYGWVSILGRTGILSVTLREAGLTDRPIQFLYSFDAVVVGLLTILLPFMVVSITNSLTAIDQRYTEAAQSLGAGPWQTFFRVTLPLSSPGVTSGLMLVTFLMLSAYVTIALLGGPRFKLLVSLVFDSAATFRWPRAAALSFVLLAIALVIAAAIQIVMRPQRVQGKGT
>NZ_CP012334.1|WP_066638904.1|3934213_3935002_-|ABC-transporter-permease
MSAGRFLLRLITGIALVLILGPILVIFLFAFSSADTLVFPPPGFSLRWFQAFFTIPEMRQAFGLSLWLAFVSATLAGLLGLLAAIYASRRRGWLSNLLQMLFMAPLVFPTIILGLALLLLYRTLGVAILPGLLIAHVVVCLPYAFRAIVAALQAFDTALEEAGLSLGAGPIKSFMLITMPIIWPALLSAWLFAFIVSFGELNAALFLTGPGIVTLPIEIFSYLQFQGSQLVVAAASALQVIMIILILVLAERIVGARRIVQR
>NZ_CP012334.1|WP_066638928.1|3948849_3951087_+|TonB-dependent-siderophore-receptor
MFQLFLSRSGSYAGLSLSPPRSAGRPGPSALALAIRLAFAGVAAGSTTLPAGAWAQTAAPVTTLAPVSVTATAVTESDTLPPVYAGGQVAKGARLGVLGEQDAANVPFSVTSFTSQLVEDQQARTLGDVLRNDPSVQVTRGFGNDAQLFVIRGFQLNGDDISYGGLFGVMPRQIISPQGAERIEIFKGPSAFLNGVPPGGSGVGGMVNIEPKRAGDDPLTRLSVDYGTASQRGAAADIGRRWGASNQFGIRVNALQREGDTGIHDDSTRMTFGSVGMDYRGERLRASLDLGYQKQRTRQGRPMVQVIGDDIPDAPSAGHNYAQPWTYSMTENTFGMLRAEYDLAERWTAYAAIGGNHAREKGSYSSLTVNGDGVGTASRLDVPYESDTYGMMGGVRGKFETGPLTHAVNAAFSSVYLKKRSAFTFGSSFATRLDDTPEVASPPTILTGGNMDDPGVTGRNRMTGISISDTLSFLDDRVFVTVGARHQKLRVTNYAYTGEVDSKYDDSATSPVFGLVVKPWQHLSLYANHIEGLQQGPTAPLTAINANTTFAPSKSKQNEVGAKLDMGSYGASLAFFEIQQPTGVTDPATQIFSVAGEQRNRGVELNVYGEPLRGVRVIGGVSVIDATLRDTKNPATEGNDGVGVPDYTAVLNTEWDLPWVPGLTLQGRVTHAGSQYLDTANTQKVKPWTTLDLGARYAMKVDRHDVVWRLGVENVTNKRYWSSANGGYLIQGDPRTVKLSVAVDF
>NZ_CP012334.1|WP_083229130.1|3951194_3952079_+|LysR-family-transcriptional-regulator
MDLSALQMLVAAIEERSLAKAGEREHLVTSAASKRIAELERQIGTALLVRHNRGVEPTPAGAALYHKAKAILTSVRTLEGLCEEFSPDGIPKIRLAANRSAIVEFLPTDIRAFQAISPKSRLDLVEAYSGDIPRMVSDQEVDIGIYHAVGAAPGVVSFPYRSDHVVLVVPRGHPLADAPALHLDQARDYDFLGYFPRHSFEAFMELVGPTLTGPLNVKIQVANYEARCRMVREGLGIAVMPEPIADTYLSLLGLVKIRLLDDWAKRQFYVCARDRSHMRMAAGDLFDFLVKAGA
>NZ_CP012334.1|WP_066643261.1|3952107_3953523_+|L-seryl-tRNA(Sec)-selenium-transferase
MASVPARAADIPSLDRLLNAAPMRPALQQYGHTQVVGALRAHLDTLRQAALTGELAAGSIAAEAITRQVRKALDAAARPRLRAVFNLTGTVLHTNLGRALLPDDAVAAVVQALTTPANLEFDLDNGGRGDRDDLVEDLLRELTGAQAATVVNNNAAAVLLMLSSLADRREVVVSRGELVEIGGAFRIPDVMKRAGARLVEVGTTNRTHPADYESAIGPRTAMLMKVHCSNYAVTGFTSSVDVAHVADIAHRAGLPMTVDLGSGTLLDLSRWGLPREDTVRATLSAGADLVTFSGDKLLGGPQAGLIVGRADLIRRIKKNPLKRALRVGKLTLAALEPVLALYRAPELLAERLTTLRLLTRPAAQMREQAERMLPALQQALGAGYKAVAAPMFSQIGSGALPVDQLPSYGYAIRHAGPGRPGRALEKLEAALRALPRPVIGRIGDKALWLDLRCLEARDESAFLAQLQAPLA
>NZ_CP012334.1|WP_066638933.1|3953569_3953890_-|multidrug-efflux-SMR-transporter
MPWILLGAAGILEIAFASFMKMSFGFTRLTPAILTVVTGLASVILLSISLRTLPVGTGYAVWTGIGAAGTAIIGIAFLGDSAAPARMLCIGLILTGVIGLKLVSAN
>NZ_CP012334.1|WP_066638935.1|3954012_3954468_-|carboxymuconolactone-decarboxylase-family-protein
MTHRIDYIEASPEGYKALGNVYATLLKSTLPKELVDLVYLRVSQINGCAFCIDMHSRDLLKAGLAVEKLVLVPVWHESGNVFSARERAALAWAETVTRVAETGVPDADYDAAAAEFGDRELADLTYAIGLMNAFNRLGISFRKAPAAAVNA
>NZ_CP012334.1|WP_066638937.1|3954591_3956013_-|PLP-dependent-aminotransferase-family-protein
MPIAKPSHLPPLDPAAAAPFYRQIYDRFRDAIAGGVLKPGDRIPSARALTKELGLARGTIDAAYSLLAAEGYIQPRGQAGTIVTPDLKPRAPATAPVPKPENTAAAPSFRPDSVLPFQMGLPALDEFPRKIWARLGARCARAMQPPGMVHPAVYGLPELRTHIAAYLQVSRGIDCSPSQVFVTSGYRHTIALIAQALLRVGDRVWVENPGYPPTRELLRHMNIGAVPVSVDQDGMVVSEGIKRAPRARAAVVTPAHQSPLCVSLSLPRRLALLDWAARNKAWVIEDDYDGEYRYVSRPLPALKSLDREGRVLYCGTFSKVLLPSLRLAYLVVPQAQVERFEQISQIFTAGSPELTQAVVTAFFKEGHFARHIQRMRKLYAERRQATAAGLEKTLGKYVRIDTQPGGMHLILKLQGRRSDRQLVARMRQASLYAEALTEWTVDRAGTPALLLNFTNVDTQSTAETLGKRILQLM
>NZ_CP012334.1|WP_083228913.1|3956326_3957223_-|amidohydrolase-family-protein
MTKPCLPPHSAFTPLRFAVPAGACDSHAHVFGPYAHFPLSEDRSYTPPENGADRFIAHLDRLGLARGVLVTASAQGDDNRNVLQALAAHPDRLRAVGVVRAGISDKDLDDLAGQGVRGARFNLYKHDGKAVYRNGVGIDDFVALAPRLKARGMHAQIWIHAPDLPELAPTLLASGVDLVVDHQGRMNVSRGVNDPGFQFLCKLLAEGKAWTKISGADRNTAAGSPFPDIAPFATSLLKANSERVVWGTDWPHINYFNAAQVPDDGILLNLLADWMPDEATRKRVLVDNPARLYGFAAA
>NZ_CP012334.1|WP_158515188.1|3957267_3958266_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MKQFKGAVKALGMVVALALGAHAGMAAAEGYPDKPIRLVVPYPPGGNLDITTRAITTAMARYLKQSIVVENLGGAGGSIGAGNVARAAADGYTVLSTTIVPLVVNPTLVPGTRVKLGDFDPVGMLAVVPSVLEVNAKNRQGITDFKGFIAYAKAHPGEVAVAHSGTGTTNHIAELLLEQDFGIKMNPIPYKGSAPALADMLGNQVDGMVDQLTSSQPQIQNGALTALAVTSAKRVPQLANVPTVAELGKPDFEMVTYSALMTPKGTPQAVRQVLNDALAKAVADPEVQRQLANIGSQVVPSTIDQTAQIFAKEEAKLQPLLTSGVLKPDNAR
>NZ_CP012334.1|WP_066638939.1|3958295_3959084_-|class-II-aldolase/adducin-family-protein
MMKHELKISSMKEQCTEAEWEARVDLAACYRLIAHYGMSDMIANHVSLRVPGEPGAFLINAYGLLYEEITASSLLKIDHHGNILSKPDFGPHLSYGVNKAGFVIHSAIHEKRPEVDCVIHTHTWAGMAVSSLACGLLPLNQTSMRFAKIGYHDYEGVVLDLSEQESLCRDLGQNEALILRNHGLLTVGRSIGEAFNWMHRLEVSCRAQLAAMACNAPLNPVSKDVIEATWNQYQPGTRRPYGQMEWPALLRLADRLDPSYRT
>NZ_CP012334.1|WP_066638942.1|3959363_3960161_+|IclR-family-transcriptional-regulator
MSVLDNATRVLRVLAQHGGQVSVTEVVAQLGLPKSSSSRLLKQMLESGLLERDPATLRYRPALLLLEVAHQSRASTPLIRRMEQALESLVADTGHTGYISVLDDNRRDVVVVRAFPGSHLLRVVTQPGYRLPAYASSTGRALLARLDDAAARQAHPAAADPRAAVLPHAPRTLAALRAQLEQVRARGWAWALDESVTGVGSVSATVGDAQSGETLAFCLSFPASLNRPGFVDVLAHRLVGYAAAIGRAAGDSFWRTTAPASAVHD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP012334_5	5.1\|991398\|30\|NZ_CP012334\|CRISPRCasFinder	991398-991427	30	NC_016586	Azospirillum lipoferum 4B plasmid AZO_p2, complete sequence	474239-474268	6	0.8
NZ_CP012334_5	5.1\|991398\|30\|NZ_CP012334\|CRISPRCasFinder	991398-991427	30	MN703413	Arthrobacter phage Powerpuff, complete genome	40605-40634	7	0.767
NZ_CP012334_5	5.1\|991398\|30\|NZ_CP012334\|CRISPRCasFinder	991398-991427	30	MT024869	Arthrobacter phage Lego, complete genome	39403-39432	7	0.767
NZ_CP012334_5	5.1\|991398\|30\|NZ_CP012334\|CRISPRCasFinder	991398-991427	30	MT024871	Arthrobacter phage YesChef, complete genome	39464-39493	7	0.767
NZ_CP012334_5	5.1\|991398\|30\|NZ_CP012334\|CRISPRCasFinder	991398-991427	30	NZ_CP015742	Shinella sp. HZN7 plasmid pShin-06, complete sequence	101079-101108	7	0.767
NZ_CP012334_9	9.3\|2802859\|31\|NZ_CP012334\|CRISPRCasFinder	2802859-2802889	31	KY676784	Streptomyces phage ToastyFinz, complete genome	32641-32671	7	0.774
NZ_CP012334_3	3.1\|125023\|31\|NZ_CP012334\|CRISPRCasFinder	125023-125053	31	NZ_CP032325	Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence	14359-14389	8	0.742
NZ_CP012334_3	3.1\|125023\|31\|NZ_CP012334\|CRISPRCasFinder	125023-125053	31	NZ_CP007796	Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence	676619-676649	8	0.742
NZ_CP012334_3	3.1\|125023\|31\|NZ_CP012334\|CRISPRCasFinder	125023-125053	31	NZ_CP032342	Azospirillum brasilense strain MTCC4038 plasmid p3, complete sequence	260073-260103	8	0.742
NZ_CP012334_3	3.1\|125023\|31\|NZ_CP012334\|CRISPRCasFinder	125023-125053	31	NZ_CP033321	Azospirillum brasilense strain Cd plasmid p3, complete sequence	97302-97332	8	0.742
NZ_CP012334_3	3.1\|125023\|31\|NZ_CP012334\|CRISPRCasFinder	125023-125053	31	NZ_CP033315	Azospirillum brasilense strain Sp 7 plasmid p3, complete sequence	438097-438127	8	0.742
NZ_CP012334_3	3.1\|125023\|31\|NZ_CP012334\|CRISPRCasFinder	125023-125053	31	NZ_CP032349	Azospirillum brasilense strain MTCC4039 plasmid p3, complete sequence	304679-304709	8	0.742
NZ_CP012334_9	9.3\|2802859\|31\|NZ_CP012334\|CRISPRCasFinder	2802859-2802889	31	NZ_AP022319	Burkholderia sp. THE68 plasmid BTHE68_p1, complete sequence	1107870-1107900	8	0.742
NZ_CP012334_9	9.3\|2802859\|31\|NZ_CP012334\|CRISPRCasFinder	2802859-2802889	31	NZ_CP011665	Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence	179733-179763	9	0.71

1. spacer 5.1|991398|30|NZ_CP012334|CRISPRCasFinder matches to NC_016586 (Azospirillum lipoferum 4B plasmid AZO_p2, complete sequence) position: , mismatch: 6, identity: 0.8

cagcggaccggagggaaggcccacccccac	CRISPR spacer
cagcggacaggagggaaggcccagcgcgca	Protospacer
******** ************** * *

2. spacer 5.1|991398|30|NZ_CP012334|CRISPRCasFinder matches to MN703413 (Arthrobacter phage Powerpuff, complete genome) position: , mismatch: 7, identity: 0.767

cagcggaccggagggaaggcccacccccac	CRISPR spacer
tacacgaccggaggtaaggcccaccccggc	Protospacer
.*   ********* ************ .*

3. spacer 5.1|991398|30|NZ_CP012334|CRISPRCasFinder matches to MT024869 (Arthrobacter phage Lego, complete genome) position: , mismatch: 7, identity: 0.767

cagcggaccggagggaaggcccacccccac	CRISPR spacer
tacacgaccggaggcaaggcccaccccggc	Protospacer
.*   ********* ************ .*

4. spacer 5.1|991398|30|NZ_CP012334|CRISPRCasFinder matches to MT024871 (Arthrobacter phage YesChef, complete genome) position: , mismatch: 7, identity: 0.767

cagcggaccggagggaaggcccacccccac	CRISPR spacer
tacacgaccggaggtaaggcccaccccggc	Protospacer
.*   ********* ************ .*

5. spacer 5.1|991398|30|NZ_CP012334|CRISPRCasFinder matches to NZ_CP015742 (Shinella sp. HZN7 plasmid pShin-06, complete sequence) position: , mismatch: 7, identity: 0.767

cagcggaccggagggaaggcccacccccac	CRISPR spacer
caaggcgccggagggcaggcccaccccctg	Protospacer
**. * .******** ************

6. spacer 9.3|2802859|31|NZ_CP012334|CRISPRCasFinder matches to KY676784 (Streptomyces phage ToastyFinz, complete genome) position: , mismatch: 7, identity: 0.774

ttcttcagcgaaccggccaacgtccgcggaa	CRISPR spacer
gacctcaccgacccggccaacgtccgcgtga	Protospacer
  *.*** *** **************** .*

7. spacer 3.1|125023|31|NZ_CP012334|CRISPRCasFinder matches to NZ_CP032325 (Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence) position: , mismatch: 8, identity: 0.742

gggggcgacgccggcggaccggaaggaagac	CRISPR spacer
cagcgcgacgccggcgaaccggtaggagagc	Protospacer
 .* ************.***** ****...*

8. spacer 3.1|125023|31|NZ_CP012334|CRISPRCasFinder matches to NZ_CP007796 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence) position: , mismatch: 8, identity: 0.742

gggggcgacgccggcggaccggaaggaagac	CRISPR spacer
cagcgcgacgccggcgaaccggtaggagagc	Protospacer
 .* ************.***** ****...*

9. spacer 3.1|125023|31|NZ_CP012334|CRISPRCasFinder matches to NZ_CP032342 (Azospirillum brasilense strain MTCC4038 plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.742

gggggcgacgccggcggaccggaaggaagac	CRISPR spacer
cagcgcgacgccggcgaaccggtaggagagc	Protospacer
 .* ************.***** ****...*

10. spacer 3.1|125023|31|NZ_CP012334|CRISPRCasFinder matches to NZ_CP033321 (Azospirillum brasilense strain Cd plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.742

gggggcgacgccggcggaccggaaggaagac	CRISPR spacer
cagcgcgacgccggcgaaccggtaggagagc	Protospacer
 .* ************.***** ****...*

11. spacer 3.1|125023|31|NZ_CP012334|CRISPRCasFinder matches to NZ_CP033315 (Azospirillum brasilense strain Sp 7 plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.742

gggggcgacgccggcggaccggaaggaagac	CRISPR spacer
cagcgcgacgccggcgaaccggtaggagagc	Protospacer
 .* ************.***** ****...*

12. spacer 3.1|125023|31|NZ_CP012334|CRISPRCasFinder matches to NZ_CP032349 (Azospirillum brasilense strain MTCC4039 plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.742

gggggcgacgccggcggaccggaaggaagac	CRISPR spacer
cagcgcgacgccggcgaaccggtaggagagc	Protospacer
 .* ************.***** ****...*

13. spacer 9.3|2802859|31|NZ_CP012334|CRISPRCasFinder matches to NZ_AP022319 (Burkholderia sp. THE68 plasmid BTHE68_p1, complete sequence) position: , mismatch: 8, identity: 0.742

ttcttcagcgaaccggccaacgtccgcggaa	CRISPR spacer
cgcttcggcggaccggccaacgtccatgaat	Protospacer
. ****.***.**************..*.*

14. spacer 9.3|2802859|31|NZ_CP012334|CRISPRCasFinder matches to NZ_CP011665 (Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence) position: , mismatch: 9, identity: 0.71

ttcttcagcgaaccggccaacgtccgcggaa	CRISPR spacer
gacgtcaccgacccggccaacgtccgctacc	Protospacer
  * *** *** *************** .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

660488 : 734167

Burkholderia_phage(18.42%)

portal,tRNA,plate,holin,terminase,protease,integrase,tail,capsid,head

attL 700606:700622|attR 734290:734306

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_066632258.1\|660488_661901_-\|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
WP_066632259.1\|661959_664416_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_066632260.1\|664408_665092_-	carboxylesterase	NA	NA	NA	NA
WP_066632261.1\|665103_665643_-	ribosome-associated protein	NA	NA	NA	NA
WP_066632263.1\|665703_667068_+\|protease	metalloprotease PmbA	NA	NA	NA	NA
WP_066632265.1\|667287_668439_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_066632267.1\|668534_669416_+	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_066642022.1\|669422_670289_+	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_066632269.1\|670281_671070_+	ABC transporter ATP-binding protein	A0A2R8FG22	Brazilian_cedratvirus	7.2e-12	23.9
WP_066632271.1\|671066_671777_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.7e-12	23.3
WP_066632273.1\|671967_672396_+	50S ribosomal protein L13	NA	NA	NA	NA
WP_066355857.1\|672405_672798_+	30S ribosomal protein S9	NA	NA	NA	NA
WP_066632277.1\|673107_674172_+	N-acetyl-gamma-glutamyl-phosphate reductase	NA	NA	NA	NA
WP_066632279.1\|674221_675253_+	hypothetical protein	NA	NA	NA	NA
WP_066632281.1\|675362_675734_+	iron-sulfur cluster insertion protein ErpA	A0A2H4N7M3	Lake_Baikal_phage	1.4e-29	56.5
WP_066632283.1\|675854_676973_-	anhydro-N-acetylmuramic acid kinase	NA	NA	NA	NA
WP_083229060.1\|676998_678258_-	M23 family metallopeptidase	A8ATH6	Listeria_phage	7.5e-19	44.7
WP_066632286.1\|678566_679796_+\|tRNA	tyrosine--tRNA ligase	NA	NA	NA	NA
WP_066632288.1\|679856_680510_+	YbhB/YbcL family Raf kinase inhibitor-like protein	NA	NA	NA	NA
WP_066632290.1\|680772_682017_+	serine hydroxymethyltransferase	A0A219YCZ0	Aeromonas_phage	1.0e-100	54.2
WP_066632292.1\|682032_682515_+	transcriptional repressor NrdR	NA	NA	NA	NA
WP_066632295.1\|682549_683656_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	4.4e-39	33.1
WP_066632296.1\|683809_684460_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	8.9e-24	34.3
WP_066642026.1\|684737_686660_+	PrkA family serine protein kinase	NA	NA	NA	NA
WP_066632297.1\|686670_687936_+	YeaH/YhbH family protein	NA	NA	NA	NA
WP_145925178.1\|687944_689468_+	SpoVR family protein	NA	NA	NA	NA
WP_066642028.1\|689668_691480_+	dipeptide ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.8e-13	30.7
WP_066632299.1\|691539_693069_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_066632300.1\|693118_694042_+	ABC transporter permease	NA	NA	NA	NA
WP_066642030.1\|694047_694911_+	ABC transporter permease	NA	NA	NA	NA
WP_066632305.1\|694914_696660_+	peptidase M14	NA	NA	NA	NA
WP_066632307.1\|696740_697205_-	outer membrane protein assembly factor BamE	NA	NA	NA	NA
WP_066632309.1\|697429_699562_-	hypothetical protein	NA	NA	NA	NA
WP_066632310.1\|699814_700408_+	cysteine hydrolase	NA	NA	NA	NA
700606:700622	attL	NA	NA	NA	NA
WP_066632311.1\|700963_702286_+\|integrase	integrase arm-type DNA-binding domain-containing protein	B7SYF8	Stenotrophomonas_phage	4.0e-79	42.5
WP_066632312.1\|702803_705596_-	hypothetical protein	A0A1S5NPU9	Burkholderia_phage	5.9e-250	49.2
WP_076879654.1\|705624_705858_-	hypothetical protein	NA	NA	NA	NA
WP_158515144.1\|705955_706129_-	hypothetical protein	NA	NA	NA	NA
WP_066632314.1\|706380_706671_-	hypothetical protein	NA	NA	NA	NA
WP_066632315.1\|706755_707175_-	hypothetical protein	NA	NA	NA	NA
WP_076879751.1\|707171_707432_-	ogr/Delta-like zinc finger family protein	NA	NA	NA	NA
WP_066632316.1\|707473_707677_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_066632317.1\|707759_708215_+	helix-turn-helix transcriptional regulator	A0A2H4J6Q0	uncultured_Caudovirales_phage	2.4e-15	53.6
WP_066632318.1\|708332_709361_-	late control protein	A0A2H4JAV0	uncultured_Caudovirales_phage	4.0e-71	43.2
WP_066632322.1\|709357_709822_-\|tail	phage tail protein	Q9ZXJ9	Pseudomonas_virus	7.0e-31	50.7
WP_066632324.1\|709831_712597_-	hypothetical protein	A4JWS3	Burkholderia_virus	2.9e-209	43.1
WP_076879655.1\|712599_712716_-\|tail	GpE family phage tail protein	Q9ZXK1	Pseudomonas_virus	7.8e-08	70.3
WP_066632326.1\|712724_713081_-\|tail	phage tail assembly protein	A0A1S6KZZ9	Salmonella_phage	2.8e-16	50.6
WP_066632329.1\|713095_713617_-\|tail	phage major tail tube protein	Q9ZXK3	Pseudomonas_virus	3.5e-47	54.3
WP_066642032.1\|713675_714854_-\|tail	phage tail sheath protein	A0A2H4JCP8	uncultured_Caudovirales_phage	3.7e-145	63.5
WP_066632331.1\|714980_715772_-	DNA adenine methylase	Q5ZQW7	Pseudomonas_phage	1.1e-111	70.2
WP_066642034.1\|716195_717191_+\|integrase	site-specific integrase	A0A2H4JE37	uncultured_Caudovirales_phage	2.7e-24	29.9
WP_083228589.1\|717187_717532_-\|tail	phage tail protein	NA	NA	NA	NA
WP_145925179.1\|717528_718092_-	hypothetical protein	NA	NA	NA	NA
WP_066632336.1\|718597_719920_-	hypothetical protein	A0A0M3ULH6	Salmonella_phage	1.0e-50	61.8
WP_066632338.1\|719916_720534_-\|tail	phage tail protein I	E5G6N9	Salmonella_phage	6.6e-53	50.5
WP_066632339.1\|720526_721456_-\|plate	baseplate assembly protein	A0A218M4K5	Erwinia_phage	5.1e-81	56.8
WP_083229061.1\|721457_721799_-	hypothetical protein	E5E3V5	Burkholderia_phage	8.8e-23	55.4
WP_066632345.1\|721810_722431_-\|plate	phage baseplate assembly protein V	A4PE41	Ralstonia_virus	1.6e-46	47.1
WP_066632346.1\|722494_722968_-	phage virion morphogenesis protein	E5FFH6	Burkholderia_phage	7.6e-33	53.0
WP_066632347.1\|722949_723447_-\|tail	phage tail protein	A0A077K8R3	Ralstonia_phage	4.5e-28	47.8
WP_066632348.1\|723506_723980_-	hypothetical protein	E5G6N2	Salmonella_phage	4.6e-14	37.4
WP_066632349.1\|723976_724786_-	DUF3380 domain-containing protein	E5FFI0	Burkholderia_phage	7.3e-68	53.0
WP_083228590.1\|724778_725078_-\|holin	phage holin family protein	NA	NA	NA	NA
WP_066632351.1\|725074_725434_-	hypothetical protein	NA	NA	NA	NA
WP_145925393.1\|725442_725649_-\|tail	phage tail protein	A0A0F7LCN2	Escherichia_phage	8.4e-13	56.7
WP_066632355.1\|725645_726122_-\|head	head completion/stabilization protein	A4PE32	Ralstonia_virus	6.3e-27	46.2
WP_066632357.1\|726208_726916_-	hypothetical protein	K4NX86	Burkholderia_phage	1.3e-36	40.7
WP_066632361.1\|726917_727934_-\|capsid	phage major capsid protein, P2 family	E5FFI6	Burkholderia_phage	4.7e-112	61.4
WP_066632362.1\|727983_728805_-\|capsid	GPO family capsid scaffolding protein	E5FFI7	Burkholderia_phage	2.1e-54	49.4
WP_066632363.1\|728957_730712_+\|terminase	terminase ATPase subunit family protein	A4JWQ1	Burkholderia_virus	1.7e-223	66.4
WP_076879657.1\|730711_731770_+\|portal	phage portal protein	A4JWV0	Burkholderia_virus	1.6e-131	67.9
WP_066632365.1\|731766_732756_-	hypothetical protein	A0A068CDF3	Rhizobium_phage	9.6e-46	35.2
WP_066642047.1\|732758_732938_-	DUF3606 domain-containing protein	NA	NA	NA	NA
WP_145925180.1\|733016_733292_-	hypothetical protein	NA	NA	NA	NA
WP_066632369.1\|733444_734167_-	hypothetical protein	A0A2H4J5W2	uncultured_Caudovirales_phage	2.8e-42	41.4
734290:734306	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP012334

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection