CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP017175	Burkholderia mallei strain Bahrain1 chromosome 1, complete sequence	0 crisprs	WYL,DEDDh,DinG,csa3	0	0	7	0
NZ_CP017176	Burkholderia mallei strain Bahrain1 chromosome 2, complete sequence	2 crisprs	csa3,cas3	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

116033 : 120958

Burkholderia_phage(33.33%)

transposase,portal,terminase,protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004539219.1\|116033_116561_+\|protease	ClpXP protease specificity-enhancing factor	A0A1S5R3H3	Pseudomonas_phage	2.0e-21	51.0
WP_004199888.1\|116782_117280_+\|terminase	terminase	K4NXI4	Burkholderia_phage	2.6e-55	100.0
WP_004199886.1\|117276_118332_+\|portal	phage portal protein	K4NZV0	Burkholderia_phage	5.7e-206	99.4
WP_004202809.1\|118375_118732_-	putative addiction module antidote protein	A4JWV1	Burkholderia_virus	3.9e-42	100.0
WP_076835668.1\|118734_119058_-	type II toxin-antitoxin system RelE/ParE family toxin	A4JWV2	Burkholderia_virus	4.1e-54	97.2
WP_038802950.1\|119838_120958_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5

DBSCAN-SWA_2

192952 : 239819

Streptococcus_phage(28.57%)

transposase,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004191998.1\|192952_194416_-\|transposase	IS1182-like element ISBma2 family transposase	A0A1X9I5T2	Streptococcus_phage	8.8e-80	38.6
WP_004196837.1\|194522_194726_-	cold-shock protein	A0A2H4N7Y6	Lake_Baikal_phage	6.3e-21	73.1
WP_096325434.1\|195045_196165_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5
WP_011204166.1\|196276_196408_-	hypothetical protein	NA	NA	NA	NA
WP_004196846.1\|196391_196589_-	hypothetical protein	NA	NA	NA	NA
WP_004196848.1\|196611_198018_+	amino acid permease	NA	NA	NA	NA
WP_004551036.1\|198331_198667_-	c-type cytochrome	NA	NA	NA	NA
WP_004196853.1\|198693_199494_-	BON domain-containing protein	NA	NA	NA	NA
WP_004196857.1\|199512_200091_-	SIS domain-containing protein	NA	NA	NA	NA
WP_011204167.1\|200213_200696_-	YraN family protein	NA	NA	NA	NA
WP_004196861.1\|200694_201582_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	NA	NA	NA	NA
WP_004191998.1\|201676_203140_+\|transposase	IS1182-like element ISBma2 family transposase	A0A1X9I5T2	Streptococcus_phage	8.8e-80	38.6
WP_004198058.1\|203349_204612_-	Hsp70 family protein	NA	NA	NA	NA
WP_004198059.1\|205209_205815_-	nitroreductase family protein	NA	NA	NA	NA
WP_004198060.1\|205776_206352_+	hypothetical protein	NA	NA	NA	NA
WP_004198061.1\|206311_207595_-	MFS transporter	NA	NA	NA	NA
WP_004198062.1\|207753_208398_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_011204168.1\|208388_208739_+	hypothetical protein	NA	NA	NA	NA
WP_004198063.1\|208735_209359_+	DUF1415 domain-containing protein	NA	NA	NA	NA
WP_004198067.1\|210463_211600_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_011204169.1\|211596_211812_-	hypothetical protein	NA	NA	NA	NA
WP_004185303.1\|211956_213075_-	acyltransferase	NA	NA	NA	NA
WP_004199981.1\|213073_213484_+	hypothetical protein	NA	NA	NA	NA
WP_011204170.1\|213477_214020_-	hypothetical protein	NA	NA	NA	NA
WP_009922408.1\|214451_214547_-	hypothetical protein	NA	NA	NA	NA
WP_069605483.1\|214585_216751_+	peptidase M1	A0A0P0IY26	Acinetobacter_phage	2.5e-46	27.1
WP_071893038.1\|217332_217731_+	hypothetical protein	NA	NA	NA	NA
WP_011205259.1\|217773_218043_+	hypothetical protein	NA	NA	NA	NA
WP_004204906.1\|218145_218376_+	hypothetical protein	NA	NA	NA	NA
WP_012729786.1\|218609_218966_-	hypothetical protein	NA	NA	NA	NA
WP_004199991.1\|218991_220260_+	HlyD family efflux transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_004199993.1\|220274_222536_+	peptidase domain-containing ABC transporter	W8CYL7	Bacillus_phage	4.2e-36	27.7
WP_004199995.1\|222532_223981_+	TolC family protein	NA	NA	NA	NA
WP_004199997.1\|224190_225147_-	hypothetical protein	NA	NA	NA	NA
WP_004527832.1\|225158_226124_+	M15 family metallopeptidase	NA	NA	NA	NA
WP_011204174.1\|226141_226420_+	hypothetical protein	NA	NA	NA	NA
WP_004200001.1\|226395_230289_+	type VI secretion system membrane subunit TssM	NA	NA	NA	NA
WP_004200003.1\|230285_231275_+	type VI secretion system-associated protein TagF	NA	NA	NA	NA
WP_004185296.1\|231279_232212_+	OmpA family protein	NA	NA	NA	NA
WP_004200005.1\|232410_233532_-	type VI secretion system protein TssA	NA	NA	NA	NA
WP_004202807.1\|233621_236291_-	type VI secretion system ATPase TssH	A0A223W0B1	Agrobacterium_phage	3.8e-89	32.0
WP_004200010.1\|236324_237425_-\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_076839014.1\|237388_239215_-\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_011205263.1\|239306_239819_-\|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA

DBSCAN-SWA_3

1118735 : 1200055

Synechococcus_phage(13.64%)

transposase,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004191998.1\|1118735_1120199_-\|transposase	IS1182-like element ISBma2 family transposase	A0A1X9I5T2	Streptococcus_phage	8.8e-80	38.6
WP_004194336.1\|1120486_1121560_-	3-deoxy-7-phosphoheptulonate synthase AroG	A0A2I6UFP9	Klebsiella_phage	7.2e-79	47.3
WP_009922080.1\|1121670_1121838_+	hypothetical protein	NA	NA	NA	NA
WP_004194084.1\|1121969_1123466_-\|protease	metalloprotease TldD	NA	NA	NA	NA
WP_004194407.1\|1123545_1124373_-	carbon-nitrogen hydrolase family protein	M1I6H3	Paramecium_bursaria_Chlorella_virus	7.3e-15	28.0
WP_004194295.1\|1124424_1128618_-	TIGR02099 family protein	NA	NA	NA	NA
WP_004196324.1\|1128784_1131562_+	bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase	NA	NA	NA	NA
WP_004194023.1\|1131960_1133610_-	DNA repair protein RecN	NA	NA	NA	NA
WP_004200494.1\|1133639_1134542_-	NAD kinase	NA	NA	NA	NA
WP_004194248.1\|1134675_1135698_+	heat-inducible transcriptional repressor HrcA	NA	NA	NA	NA
WP_004196493.1\|1135870_1136974_+	ferrochelatase	NA	NA	NA	NA
WP_004194347.1\|1136979_1137387_+	RNA-binding S4 domain-containing protein	NA	NA	NA	NA
WP_004194243.1\|1137883_1138441_+	nucleotide exchange factor GrpE	NA	NA	NA	NA
WP_004194133.1\|1138456_1138888_+	thioredoxin family protein	NA	NA	NA	NA
WP_004194034.1\|1139033_1140986_+	molecular chaperone DnaK	A0A1V0SH73	Hokovirus	2.7e-148	49.2
WP_004194374.1\|1141252_1142383_+	molecular chaperone DnaJ	A0A1V0SBY2	Catovirus	2.9e-22	27.6
WP_004194350.1\|1142416_1144423_+	bifunctional anthranilate synthase component I family protein/class IV aminotransferase	S4VT78	Pandoravirus	9.7e-53	35.0
WP_069605506.1\|1144598_1145414_-	3-methyl-2-oxobutanoate hydroxymethyltransferase	A0A0N7HVJ8	Ostreococcus_lucimarinus_virus	6.7e-37	33.7
WP_004194274.1\|1145478_1146162_-	deoxynucleoside kinase	A0A249XZR7	Enterococcus_phage	2.6e-05	26.0
WP_004194373.1\|1146158_1146686_-	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	NA	NA	NA	NA
WP_004194112.1\|1146722_1148270_-	polynucleotide adenylyltransferase PcnB	H7BUW3	unidentified_phage	4.3e-24	31.2
WP_004194213.1\|1148266_1148953_-	HAD-IB family hydrolase	NA	NA	NA	NA
WP_004196484.1\|1148974_1149700_-	DnaA regulatory inactivator Hda	NA	NA	NA	NA
WP_004194386.1\|1149998_1151054_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SEW4	Cyanophage	2.9e-72	44.7
WP_004194381.1\|1151120_1152341_-\|transposase	ISL3-like element ISBma1 family transposase	A9YX10	Burkholderia_phage	2.3e-238	99.0
WP_004194287.1\|1152656_1153058_+	SgcJ/EcaC family oxidoreductase	NA	NA	NA	NA
WP_004194103.1\|1153075_1154050_-\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_069605507.1\|1154046_1156110_-	DNA mismatch repair endonuclease MutL	A0A1B2LRQ5	Wolbachia_phage	6.4e-76	31.6
WP_004194375.1\|1156294_1156975_+	membrane protein	NA	NA	NA	NA
WP_004550025.1\|1157295_1158168_-	mechanosensitive ion channel family protein	NA	NA	NA	NA
WP_004194053.1\|1158233_1159070_-	class II glutamine amidotransferase	NA	NA	NA	NA
WP_004194323.1\|1159340_1160768_-	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	1.3e-54	30.4
WP_011204114.1\|1161165_1163181_-	capsular polysaccharide biosynthesis protein	NA	NA	NA	NA
WP_004196472.1\|1163181_1164333_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_004194378.1\|1164513_1165677_+	polysaccharide export protein	NA	NA	NA	NA
WP_004196469.1\|1165758_1167306_+	capsular polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family	NA	NA	NA	NA
WP_004194135.1\|1167312_1168095_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_004194035.1\|1168091_1168748_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	8.7e-11	31.1
WP_004194357.1\|1168780_1170304_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_024900377.1\|1170326_1171649_+	capsular biosynthesis protein	NA	NA	NA	NA
WP_011204113.1\|1171658_1172600_+	capsular polysaccharide biosynthesis protein	NA	NA	NA	NA
WP_004194348.1\|1172596_1174393_+	DUF4214 domain-containing protein	NA	NA	NA	NA
WP_073699037.1\|1174407_1175346_+	capsular biosynthesis protein	NA	NA	NA	NA
WP_004194206.1\|1175342_1176185_+	sugar nucleotide-binding protein	A0A222YYW2	Synechococcus_phage	1.7e-38	35.0
WP_004194087.1\|1176194_1177208_+	GDP-mannose 4,6-dehydratase	A0A222YY99	Synechococcus_phage	7.2e-97	52.6
WP_004194045.1\|1177223_1178264_+	dehydrogenase	A0A222YW25	Synechococcus_phage	1.7e-61	40.5
WP_004194315.1\|1178245_1178839_+	D-sedoheptulose 7-phosphate isomerase	A0A067XQR2	Caulobacter_phage	2.5e-17	37.2
WP_004194086.1\|1178840_1179533_+	D-glycero-D-manno-heptose 1-phosphate guanosyltransferase	A0A0G2Y8M0	Acanthamoeba_polyphaga_mimivirus	7.5e-05	28.8
WP_004194255.1\|1179529_1180099_+	D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase	NA	NA	NA	NA
WP_004194360.1\|1180365_1181568_+	capsular biosynthesis protein	NA	NA	NA	NA
WP_004194054.1\|1181564_1182353_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_004196462.1\|1182366_1183887_+	LTA synthase family protein	NA	NA	NA	NA
WP_004202217.1\|1183889_1191530_+	type I polyketide synthase	NA	NA	NA	NA
WP_004194036.1\|1191526_1192444_+	UDP-3-O-acyl N-acetylglycosamine deacetylase	NA	NA	NA	NA
WP_004194209.1\|1192508_1193828_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_004194345.1\|1193836_1194529_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_096325460.1\|1195504_1196624_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5
WP_004196461.1\|1197443_1199744_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	5.1e-167	42.1
WP_004194131.1\|1199740_1200055_-\|protease	ATP-dependent Clp protease adapter ClpS	A0A218MMY6	uncultured_virus	4.4e-13	44.6

DBSCAN-SWA_4

2173094 : 2222494

Leptospira_phage(22.22%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004187628.1\|2173094_2174315_+\|transposase	ISL3-like element ISBma1 family transposase	A9YX10	Burkholderia_phage	7.8e-239	99.5
WP_009942176.1\|2174506_2174815_+	hypothetical protein	NA	NA	NA	NA
WP_009973369.1\|2174797_2174974_-	hypothetical protein	NA	NA	NA	NA
WP_081244528.1\|2177585_2177924_-	hypothetical protein	NA	NA	NA	NA
WP_004192661.1\|2178002_2180375_-	penicillin acylase family protein	NA	NA	NA	NA
WP_004197788.1\|2180499_2181675_-	carbamoyltransferase	E3SL71	Synechococcus_phage	1.8e-46	35.9
WP_038802950.1\|2181762_2182882_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5
WP_155762420.1\|2183174_2183498_-	hypothetical protein	NA	NA	NA	NA
WP_069605571.1\|2183388_2184942_+	collagen-like triple helix repeat-containing protein	NA	NA	NA	NA
WP_004192734.1\|2184991_2186257_+	lipoprotein	NA	NA	NA	NA
WP_011203914.1\|2186407_2188087_+	ShlB/FhaC/HecB family hemolysin secretion/activation protein	NA	NA	NA	NA
WP_009920703.1\|2188211_2188343_+	hypothetical protein	NA	NA	NA	NA
WP_004193599.1\|2188330_2188792_+	DUF2147 domain-containing protein	NA	NA	NA	NA
WP_004191720.1\|2189028_2189439_-\|transposase	transposase	NA	NA	NA	NA
WP_004526858.1\|2189410_2189629_-	hypothetical protein	NA	NA	NA	NA
WP_004550551.1\|2189633_2190731_-	cell division protein ZapE	NA	NA	NA	NA
WP_004191219.1\|2190837_2192268_-	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	1.9e-42	27.8
WP_004192735.1\|2192367_2193642_-	2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase	NA	NA	NA	NA
WP_004191889.1\|2193769_2196634_-	2-oxoglutarate dehydrogenase E1 component	NA	NA	NA	NA
WP_004193111.1\|2196972_2198799_-	translational GTPase TypA	NA	NA	NA	NA
WP_009930591.1\|2198795_2198951_-	hypothetical protein	NA	NA	NA	NA
WP_004192835.1\|2199091_2199589_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_004191557.1\|2199688_2201185_+	efflux transporter outer membrane subunit	NA	NA	NA	NA
WP_004192058.1\|2201252_2202488_+	HlyD family efflux transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_004193982.1\|2202510_2204070_+	DHA2 family efflux MFS transporter permease subunit	NA	NA	NA	NA
WP_004191998.1\|2204183_2205647_+\|transposase	IS1182-like element ISBma2 family transposase	A0A1X9I5T2	Streptococcus_phage	8.8e-80	38.6
WP_011203915.1\|2205937_2206873_-\|tRNA	tRNA pseudouridine(55) synthase TruB	NA	NA	NA	NA
WP_004199441.1\|2206899_2207268_-	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_004197388.1\|2207373_2210301_-	translation initiation factor IF-2	A0A2H4UTS4	Bodo_saltans_virus	5.2e-23	25.3
WP_004193517.1\|2210392_2211868_-	transcription termination/antitermination protein NusA	NA	NA	NA	NA
WP_004193908.1\|2211864_2212326_-	ribosome maturation factor RimP	NA	NA	NA	NA
WP_004191876.1\|2212630_2214295_-	pseudouridine synthase	NA	NA	NA	NA
WP_004192767.1\|2214358_2215687_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	5.3e-23	35.1
WP_004193481.1\|2216105_2217008_-	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	4.5e-10	23.6
WP_004550556.1\|2217201_2217399_-	hypothetical protein	NA	NA	NA	NA
WP_004199443.1\|2217426_2217828_+\|transposase	transposase	NA	NA	NA	NA
WP_009920735.1\|2217847_2217949_+	hypothetical protein	NA	NA	NA	NA
WP_004521676.1\|2218033_2218291_+	hypothetical protein	NA	NA	NA	NA
WP_004199444.1\|2218449_2218767_-	hypothetical protein	NA	NA	NA	NA
WP_004192638.1\|2218967_2219690_+	YdcF family protein	NA	NA	NA	NA
WP_004192834.1\|2219928_2220207_+	hypothetical protein	NA	NA	NA	NA
WP_004191628.1\|2220355_2220613_+	hypothetical protein	NA	NA	NA	NA
WP_004193694.1\|2220662_2220953_-	hypothetical protein	NA	NA	NA	NA
WP_038802950.1\|2221374_2222494_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5

DBSCAN-SWA_5

2427699 : 2478660

Burkholderia_phage(12.5%)

transposase,coat,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004199459.1\|2427699_2428719_+\|tRNA	tRNA dihydrouridine(20/20a) synthase DusA	NA	NA	NA	NA
WP_004187628.1\|2429445_2430666_+\|transposase	ISL3-like element ISBma1 family transposase	A9YX10	Burkholderia_phage	7.8e-239	99.5
WP_004547020.1\|2430675_2430810_+	hypothetical protein	NA	NA	NA	NA
WP_004192691.1\|2430993_2431248_-	hypothetical protein	NA	NA	NA	NA
WP_011205090.1\|2431321_2431567_-	hypothetical protein	NA	NA	NA	NA
WP_004191306.1\|2431648_2431864_-	transporter	NA	NA	NA	NA
WP_004193270.1\|2431952_2432960_-	ATP-binding cassette domain-containing protein	G3M9Y6	Bacillus_virus	7.8e-27	36.0
WP_004191980.1\|2432956_2433778_-	aliphatic sulfonate ABC transporter permease SsuC	NA	NA	NA	NA
WP_004192866.1\|2433795_2434953_-	FMNH2-dependent alkanesulfonate monooxygenase	NA	NA	NA	NA
WP_004199465.1\|2436208_2437351_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_004191709.1\|2437380_2437719_-	multidrug efflux SMR transporter	E5EPE2	Acinetobacter_phage	8.7e-07	33.6
WP_004199466.1\|2437723_2438221_-	heme-degrading domain-containing protein	NA	NA	NA	NA
WP_011203956.1\|2438694_2438943_+	hypothetical protein	NA	NA	NA	NA
WP_004193229.1\|2438939_2439485_+	NUDIX hydrolase	NA	NA	NA	NA
WP_024900429.1\|2439493_2440261_+\|tRNA	leucyl/phenylalanyl-tRNA--protein transferase	NA	NA	NA	NA
WP_004192823.1\|2440294_2441125_+	arginyltransferase	NA	NA	NA	NA
WP_004193208.1\|2441229_2442267_+	quinone-dependent dihydroorotate dehydrogenase	NA	NA	NA	NA
WP_069605573.1\|2442377_2443172_+	cystine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_004521640.1\|2443301_2443961_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_038802950.1\|2444136_2445257_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5
WP_011807697.1\|2445287_2446004_-	YbfB/YjiJ family MFS transporter	NA	NA	NA	NA
WP_004192193.1\|2446150_2447116_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_004204967.1\|2447619_2450244_-\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	5.5e-80	39.2
WP_069605541.1\|2450929_2452150_+	CoA transferase	NA	NA	NA	NA
WP_011203892.1\|2452279_2452744_-	hypothetical protein	NA	NA	NA	NA
WP_004193654.1\|2452960_2454670_+\|tRNA	glutamine--tRNA ligase/YqeY domain fusion protein	A0A222YZ70	Escherichia_phage	8.8e-188	57.5
WP_011203891.1\|2455001_2455475_-	NUDIX hydrolase	A0A2I6PFL2	Proteus_phage	3.7e-19	41.3
WP_004193860.1\|2455502_2455889_-	hypothetical protein	NA	NA	NA	NA
WP_004196725.1\|2458190_2458370_+	hypothetical protein	NA	NA	NA	NA
WP_004192265.1\|2458366_2459227_+	M15 family metallopeptidase	NA	NA	NA	NA
WP_011203890.1\|2459270_2460395_-	cytochrome-c peroxidase	NA	NA	NA	NA
WP_004521730.1\|2460829_2462503_+	acid phosphatase	NA	NA	NA	NA
WP_004192836.1\|2462699_2463893_+	trans-2-enoyl-CoA reductase family protein	NA	NA	NA	NA
WP_004196723.1\|2463951_2464272_+	hypothetical protein	NA	NA	NA	NA
WP_004191546.1\|2464511_2465699_+	HlyD family secretion protein	NA	NA	NA	NA
WP_004192651.1\|2465871_2467491_+	DHA2 family efflux MFS transporter permease subunit	NA	NA	NA	NA
WP_004192810.1\|2469480_2470113_-	response regulator transcription factor	NA	NA	NA	NA
WP_004552891.1\|2470113_2472195_-	response regulator	A0A1V0SGR3	Hokovirus	1.7e-12	26.8
WP_004196717.1\|2472605_2473571_-\|coat	spore coat protein U domain-containing protein	NA	NA	NA	NA
WP_004191504.1\|2476043_2476883_-	molecular chaperone	NA	NA	NA	NA
WP_004526783.1\|2476900_2477425_-\|coat	spore coat protein U domain-containing protein	NA	NA	NA	NA
WP_004191870.1\|2477501_2478062_-\|coat	spore coat protein U domain-containing protein	NA	NA	NA	NA
WP_004192149.1\|2478114_2478660_-\|coat	spore coat protein U domain-containing protein	NA	NA	NA	NA

DBSCAN-SWA_6

2866877 : 2919543

Leptospira_phage(18.18%)

transposase,coat,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_038802950.1\|2866877_2867998_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5
WP_004193468.1\|2868106_2868583_-	hypothetical protein	NA	NA	NA	NA
WP_009970291.1\|2868681_2869023_+	hypothetical protein	NA	NA	NA	NA
WP_004200110.1\|2869039_2869264_+	hypothetical protein	NA	NA	NA	NA
WP_004193210.1\|2869536_2870673_+	D-alanyl-D-alanine carboxypeptidase	NA	NA	NA	NA
WP_004522511.1\|2870770_2871310_-\|protease	serine protease inhibitor ecotin	NA	NA	NA	NA
WP_004192840.1\|2871482_2871863_+	lipoprotein	NA	NA	NA	NA
WP_153260185.1\|2871828_2871975_+	hypothetical protein	NA	NA	NA	NA
WP_011204204.1\|2872469_2872880_-	hypothetical protein	NA	NA	NA	NA
WP_004192184.1\|2872896_2873277_+	hypothetical protein	NA	NA	NA	NA
WP_009935757.1\|2873477_2873702_-	hypothetical protein	NA	NA	NA	NA
WP_004266384.1\|2873851_2874364_+	YbhB/YbcL family Raf kinase inhibitor-like protein	NA	NA	NA	NA
WP_004192472.1\|2874487_2875861_+	MFS transporter	NA	NA	NA	NA
WP_004191641.1\|2876600_2877212_+	membrane protein	NA	NA	NA	NA
WP_004191763.1\|2877384_2877987_-	AAA family ATPase	A0A219VHB7	Ochrobactrum_phage	2.6e-25	62.8
WP_004192381.1\|2877979_2879398_-	alpha,alpha-trehalose-phosphate synthase (UDP-forming)	NA	NA	NA	NA
WP_004200093.1\|2879532_2879730_-	hypothetical protein	NA	NA	NA	NA
WP_011204202.1\|2879832_2880036_-	lipoprotein	NA	NA	NA	NA
WP_004193447.1\|2880017_2880548_+	lipoprotein	NA	NA	NA	NA
WP_038802950.1\|2880447_2881567_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5
WP_004192968.1\|2882032_2883373_-	nitrate/sulfonate/bicarbonate ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	8.2e-32	37.7
WP_004192556.1\|2883426_2885184_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_004550756.1\|2885278_2885554_+	hypothetical protein	NA	NA	NA	NA
WP_004198606.1\|2885680_2885947_+	hypothetical protein	NA	NA	NA	NA
WP_004193003.1\|2886019_2887333_-	HAMP domain-containing protein	NA	NA	NA	NA
WP_004191521.1\|2887316_2888015_-	response regulator	W8CYM9	Bacillus_phage	2.9e-28	36.7
WP_004192043.1\|2888256_2888802_+	periplasmic heavy metal sensor	NA	NA	NA	NA
WP_004198602.1\|2890229_2891006_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_004191164.1\|2891216_2891906_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_004193161.1\|2891902_2892616_+	ABC transporter permease	NA	NA	NA	NA
WP_004192946.1\|2892650_2893418_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.8e-26	40.0
WP_004194381.1\|2894294_2895515_-\|transposase	ISL3-like element ISBma1 family transposase	A9YX10	Burkholderia_phage	2.3e-238	99.0
WP_004534273.1\|2895615_2896716_+	porin	NA	NA	NA	NA
WP_004193987.1\|2897184_2897523_-	P-II family nitrogen regulator	NA	NA	NA	NA
WP_004198600.1\|2897583_2899284_-	NAD+ synthase	A0A2L0UZF5	Agrobacterium_phage	5.8e-91	36.8
WP_004192390.1\|2899404_2900583_+	N-acetyltransferase	NA	NA	NA	NA
WP_011203872.1\|2900563_2900824_-	hypothetical protein	NA	NA	NA	NA
WP_069605551.1\|2901582_2902623_+	GIY-YIG nuclease family protein	W8W2G4	Invertebrate_iridovirus	2.4e-07	43.1
WP_004192356.1\|2902681_2903209_-	inorganic diphosphatase	A0A2H4J8U1	uncultured_Caudovirales_phage	9.0e-51	53.8
WP_004193515.1\|2903369_2904809_+	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_004192728.1\|2904897_2905656_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_004192161.1\|2905694_2907002_+	MFS transporter	NA	NA	NA	NA
WP_004193604.1\|2907182_2908373_-	heme biosynthesis protein HemY	NA	NA	NA	NA
WP_004193146.1\|2908377_2910357_-	fused uroporphyrinogen-III synthase HemD/membrane protein HemX	NA	NA	NA	NA
WP_004193185.1\|2910356_2911346_-	hydroxymethylbilane synthase	NA	NA	NA	NA
WP_004199404.1\|2911380_2911560_-	hypothetical protein	NA	NA	NA	NA
WP_004191560.1\|2911672_2914657_+	phosphoenolpyruvate carboxylase	NA	NA	NA	NA
WP_004191998.1\|2914802_2916266_+\|transposase	IS1182-like element ISBma2 family transposase	A0A1X9I5T2	Streptococcus_phage	8.8e-80	38.6
WP_004192680.1\|2916627_2917383_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_004192784.1\|2917565_2918381_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_011203870.1\|2918553_2919543_-\|coat	spore coat U domain-containing protein	NA	NA	NA	NA

DBSCAN-SWA_7

3491742 : 3548112

Vibrio_phage(17.65%)

transposase,portal,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004191998.1\|3491742_3493206_-\|transposase	IS1182-like element ISBma2 family transposase	A0A1X9I5T2	Streptococcus_phage	8.8e-80	38.6
WP_004190029.1\|3493373_3494144_-	exodeoxyribonuclease III	R4TWA8	Phaeocystis_globosa_virus	3.4e-30	33.8
WP_004189747.1\|3494175_3495015_-	hypothetical protein	NA	NA	NA	NA
WP_004190092.1\|3495141_3496614_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_004189326.1\|3496616_3498107_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_004189769.1\|3498219_3498519_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_004189550.1\|3498884_3499928_+	rod shape-determining protein	NA	NA	NA	NA
WP_004189331.1\|3500047_3501121_+	rod shape-determining protein MreC	NA	NA	NA	NA
WP_004189260.1\|3501117_3501630_+	rod shape-determining protein MreD	NA	NA	NA	NA
WP_004189575.1\|3501813_3504222_+	penicillin-binding protein 2	NA	NA	NA	NA
WP_004189171.1\|3504233_3505382_+	rod shape-determining protein RodA	NA	NA	NA	NA
WP_004190168.1\|3505802_3506579_-	sel1 repeat family protein	NA	NA	NA	NA
WP_004189570.1\|3506575_3507361_-	2-dehydro-3-deoxyglucarate aldolase	NA	NA	NA	NA
WP_009962395.1\|3507353_3507686_+	hypothetical protein	NA	NA	NA	NA
WP_004189793.1\|3507782_3508235_-	6-carboxytetrahydropterin synthase QueD	A0A088FAL2	Vibrio_phage	7.6e-14	30.8
WP_004189241.1\|3508254_3508887_-	7-carboxy-7-deazaguanine synthase	R4TAH8	Halovirus	2.1e-06	30.9
WP_004190026.1\|3508980_3509715_-	7-cyano-7-deazaguanine synthase QueC	A0A1B0Z0B4	Vibrio_phage	1.6e-50	42.5
WP_009918037.1\|3509711_3510002_-	hypothetical protein	NA	NA	NA	NA
WP_004189647.1\|3510182_3510866_-	response regulator	NA	NA	NA	NA
WP_004189034.1\|3510866_3513275_-	PAS domain-containing sensor histidine kinase	NA	NA	NA	NA
WP_004188929.1\|3513276_3513867_-	DUF4390 domain-containing protein	NA	NA	NA	NA
WP_004189046.1\|3513863_3515273_-	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	NA	NA	NA	NA
WP_004189409.1\|3515650_3516508_-\|protease	zinc metalloprotease HtpX	NA	NA	NA	NA
WP_004189288.1\|3516617_3517253_-	LysE family translocator	NA	NA	NA	NA
WP_004200737.1\|3517373_3518357_-\|tRNA	methionyl-tRNA formyltransferase	E3SNR5	Prochlorococcus_phage	1.3e-07	38.0
WP_004201745.1\|3518388_3518892_-	peptide deformylase	A0A067XQZ3	Caulobacter_phage	2.7e-12	34.3
WP_004190020.1\|3519120_3520311_+	DNA-protecting protein DprA	S6BFL3	Thermus_phage	2.0e-21	39.2
WP_004190199.1\|3520370_3520742_+	thioredoxin family protein	NA	NA	NA	NA
WP_004200734.1\|3520952_3523562_+	DNA topoisomerase III	A0A2P1ELA0	Moumouvirus	7.7e-18	25.7
WP_004189230.1\|3523783_3524839_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_004188904.1\|3525288_3526305_+	D-2-hydroxyacid dehydrogenase family protein	NA	NA	NA	NA
WP_004189208.1\|3526425_3527295_-	patatin-like phospholipase family protein	NA	NA	NA	NA
WP_004200732.1\|3527332_3527737_-	PaaI family thioesterase	NA	NA	NA	NA
WP_004187628.1\|3528127_3529348_+\|transposase	ISL3-like element ISBma1 family transposase	A9YX10	Burkholderia_phage	7.8e-239	99.5
WP_155762413.1\|3529443_3530563_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	6.2e-49	39.5
WP_004200731.1\|3530615_3531098_+	DUF2778 domain-containing protein	NA	NA	NA	NA
WP_004188977.1\|3531094_3531379_+	hypothetical protein	NA	NA	NA	NA
WP_004188948.1\|3531451_3532465_-\|portal	phage portal protein	A4JWQ2	Burkholderia_virus	1.3e-194	99.4
WP_011203781.1\|3533117_3533282_-	hypothetical protein	NA	NA	NA	NA
WP_004189258.1\|3533488_3534364_-	N-carbamoylputrescine amidase	A7IVZ1	Paramecium_bursaria_Chlorella_virus	9.6e-74	47.3
WP_004190014.1\|3534374_3535487_-	histone deacetylase	A0A2K9KZC4	Tupanvirus	3.2e-37	30.8
WP_004201742.1\|3535515_3536610_-	polyamine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_004189434.1\|3536752_3537721_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_004189874.1\|3537823_3538393_+	periplasmic heavy metal sensor	NA	NA	NA	NA
WP_004189689.1\|3538979_3539528_+	hypothetical protein	NA	NA	NA	NA
WP_011203779.1\|3539543_3539795_+	hypothetical protein	NA	NA	NA	NA
WP_004189592.1\|3539791_3541240_+	RNA polymerase sigma factor RpoD/SigA	A0A2I7SAT0	Vibrio_phage	4.9e-30	33.5
WP_004204797.1\|3541258_3542860_-	glutamate--cysteine ligase	NA	NA	NA	NA
WP_004200726.1\|3543031_3543973_-	DNA-3-methyladenine glycosylase 2 family protein	NA	NA	NA	NA
WP_004190110.1\|3543969_3545064_-	bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada	A0A0G2Y1B6	Acanthamoeba_polyphaga_mimivirus	3.8e-19	37.4
WP_004197761.1\|3545465_3545882_+	lactoylglutathione lyase	NA	NA	NA	NA
WP_004197759.1\|3546060_3546615_-	YaeQ family protein	NA	NA	NA	NA
WP_038802950.1\|3546992_3548112_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP017176

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP017176_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017176_1

2081041-2081186

Orphan

Consensus_repeat	Method
GCAGAGGCGCCGCCGCCGGAATACCCGATCATCGGGATGCTCGATCGCCGAAG	PILER-CR
CGGAATGCCCGATCATCGGGATGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP017176_1

>merge|NZ_CP017176|1|2081041-2081186|PILER-CR,CRISPRCasFinder
TCGTCGGGATGCTCGATTGCCGCAGTCACCCTCCGCCGGGGCTCCGTCGTCGGAATGCCCGATCATCGGGATGCCTGCTCGCCGAAGCACTCCACCGCAGAGGCGCCGCCGCCGGAATACCCGATCATCGGGATGCTCGATCGCCG

>NZ_CP017176|1|1|2081041-2081186|PILER-CR
TCGTCGGGATGCTCGATTGCCGCAGTCACCCTCCGCCGGGGCTCCGTCGTCGGAA	TGCCCGAT
CATCGGGATGCCTGCTCGCCGAAGCACTCCACCGCAGAGGCGCCGCCGCCGGAAT	ACCCGATCA
TCGGGATGCTCGATCGCCG

>NZ_CP017176|1|1|2081091-2081176|CRISPRCasFinder
CGGAATGCCCGATCATCGGGATGC	CTGCTCGCCGAAGCACTCCACCGCAGAGGCGCCGCCGC
CGGAATACCCGATCATCGGGATGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017176.1\|WP_011204701.1\|2092362_2092797_-\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|223149
NZ_CP017176.1\|WP_004188034.1\|2081743_2083009_+\|polyhydroxyalkanoate-depolymerase	unknown	unknown	gnl\|CDD\|130908
NZ_CP017176.1\|WP_011204700.1\|2090391_2090766_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017176.1\|WP_004187710.1\|2085173_2086976_+\|bifunctional-aminoglycoside-phosphotransferase/ATP-binding-protein	unknown	unknown	gnl\|CDD\|225098
NZ_CP017176.1\|WP_004187216.1\|2077555_2079829_-\|pyridine-nucleotide-disulfide-oxidoreductase	unknown	unknown	gnl\|CDD\|369639
NZ_CP017176.1\|WP_004187137.1\|2090738_2091188_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341411
NZ_CP017176.1\|WP_004196898.1\|2071550_2071991_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176863
NZ_CP017176.1\|WP_004205322.1\|2073738_2074674_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176109
NZ_CP017176.1\|WP_004200705.1\|2091641_2092295_+\|SagB/ThcOx-family-dehydrogenase	unknown	unknown	gnl\|CDD\|380318
NZ_CP017176.1\|WP_004187305.1\|2087498_2088530_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236122
NZ_CP017176.1\|WP_011204697.1\|2075586_2077245_+\|GMC-family-oxidoreductase	unknown	unknown	gnl\|CDD\|225186
NZ_CP017176.1\|WP_004187792.1\|2088526_2090359_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223732
NZ_CP017176.1\|WP_004200700.1\|2072325_2073441_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378454
NZ_CP017176.1\|WP_009950893.1\|2071159_2071465_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240624
NZ_CP017176.1\|WP_011204695.1\|2070501_2070828_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017176.1\|WP_011204696.1\|2074855_2075287_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017176.1\|WP_009927403.1\|2073501_2073612_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017176.1\|WP_011204702.1\|2093202_2094330_-\|porin	unknown	unknown	gnl\|CDD\|238208
NZ_CP017176.1\|WP_004187469.1\|2079961_2080357_-\|conjugal-transfer-protein-TraR	unknown	unknown	gnl\|CDD\|224648
NZ_CP017176.1\|WP_004553972.1\|2083314_2085099_+\|ribonucleotide-reductase	unknown	unknown	gnl\|CDD\|180772

Protein	Function_ID	Function_description	E-value
NZ_CP017176.1\|WP_011204701.1\|2092362_2092797_-\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	2.04683e-32
NZ_CP017176.1\|WP_004188034.1\|2081743_2083009_+\|polyhydroxyalkanoate-depolymerase	gnl\|CDD\|130908	TIGR01849, unnamed_protein_product, polyhydroxyalkanoate depolymerase, intracellular. This model represents an intracellular depolymerase for polyhydroxyalkanoate (PHA), a carbon and energy storing polyester that accumulates in granules in many bacterial species when carbon sources are abundant but other nutrients are limiting. This family is named for PHAs generally, rather than polyhydroxybutyrate (PHB) specificially as in Ralstonia eutropha H16, to avoid overcalling chemical specificity in other species. Note that this family lacks the classic GXSXG lipase motif and instead shows weak similarity to some [Fatty acid and phospholipid metabolism, Degradation].	1.36366e-112
NZ_CP017176.1\|WP_004187710.1\|2085173_2086976_+\|bifunctional-aminoglycoside-phosphotransferase/ATP-binding-protein	gnl\|CDD\|225098	COG2187, COG2187, Uncharacterized protein conserved in bacteria [Function unknown].	9.00049e-75
NZ_CP017176.1\|WP_004187216.1\|2077555_2079829_-\|pyridine-nucleotide-disulfide-oxidoreductase	gnl\|CDD\|369639	pfam07992, Pyr_redox_2, Pyridine nucleotide-disulphide oxidoreductase. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.	7.15563e-57
NZ_CP017176.1\|WP_004187137.1\|2090738_2091188_-\|CBS-domain-containing-protein	gnl\|CDD\|341411	cd17775, CBS_pair_bact_arch, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria and archaea. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	1.39507e-50
NZ_CP017176.1\|WP_004196898.1\|2071550_2071991_+\|SRPBCC-family-protein	gnl\|CDD\|176863	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins. The PYR/PYL/RCAR-like family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. PYR/PYL/RCAR plant proteins are receptors involved in signal transduction. They bind abscisic acid (ABA) and mediate its signaling. ABA is a vital plant hormone, which regulates plant growth, development, and response to environmental stresses. Upon binding ABA, these plant proteins interact with a type 2C protein phosphatase (PP2C), such as ABI1 and ABI2, and inhibit their activity. When ABA is bound, a loop (designated the gate/CL2 loop) closes over the ligand binding pocket, resulting in the weakening of the inactive PYL dimer and facilitating type 2C protein phosphatase binding. In the ABA:PYL1:ABI1 complex, the gate blocks substrate access to the phosphatase active site. A conserved Trp from PP2C inserts into PYL to lock the receptor in a closed formation. This group also contains Methylobacterium extorquens AM1 MxaD. The mxaD gene is located within the mxaFJGIR(S)ACKLDEHB cluster which encodes proteins involved in methanol oxidation. MxaD may participate in the periplasmic electron transport chain for oxidation of methanol. Mutants lacking MxaD exhibit a reduced growth on methanol, and a lower rate of respiration with methanol.	3.1145e-25
NZ_CP017176.1\|WP_004205322.1\|2073738_2074674_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176109	cd08417, PBP2_Nitroaromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of dinitrotoluene and similar compounds, such as DntR, NahR, and LinR. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. Also included are related LysR-type regulators clustered together in phylogenetic trees, including NodD, ToxR, LeuO, SyrM, TdcA, and PnbR. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.67997e-62
NZ_CP017176.1\|WP_009950893.1\|2071159_2071465_-\|hypothetical-protein	gnl\|CDD\|240624	cd05299, CtBP_dh, C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor. The transcriptional corepressor CtBP is a dehydrogenase with sequence and structural similarity to the d2-hydroxyacid dehydrogenase family. CtBP was initially identified as a protein that bound the PXDLS sequence at the adenovirus E1A C terminus, causing the loss of CR-1-mediated transactivation. CtBP binds NAD(H) within a deep cleft, undergoes a conformational change upon NAD binding, and has NAD-dependent dehydrogenase activity.	0.0059154
NZ_CP017176.1\|WP_011204697.1\|2075586_2077245_+\|GMC-family-oxidoreductase	gnl\|CDD\|225186	COG2303, BetA, Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism].	4.76839e-37
NZ_CP017176.1\|WP_004187792.1\|2088526_2090359_+\|STAS-domain-containing-protein	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	2.60835e-107
NZ_CP017176.1\|WP_004200700.1\|2072325_2073441_-\|hypothetical-protein	gnl\|CDD\|378454	pfam10604, Polyketide_cyc2, Polyketide cyclase / dehydrase and lipid transport. This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. It also includes other proteins of the START superfamily.	2.16274e-11
NZ_CP017176.1\|WP_004187305.1\|2087498_2088530_+\|hypothetical-protein	gnl\|CDD\|236122	PRK07877, PRK07877, Rv1355c family protein.	5.74738e-30
NZ_CP017176.1\|WP_004200705.1\|2091641_2092295_+\|SagB/ThcOx-family-dehydrogenase	gnl\|CDD\|380318	cd02142, McbC_SagB-like_oxidoreductase, oxidase similar to the microcin B17 processing protein McbC. This family is the oxidase domain of NRPS (non-ribosomal peptide synthetase) and other systems that modify polypeptides by cyclizing a thioester to form a ring. These include EpoB, part of the epothilone biosynthesis pathway; TubD, part of the tubulysin biosynthesis pathway, MtsD, part of the myxothiozol biosynthesis pathway; IndC, part of the indigoidine biosynthesis pathway and TfxB, part of the trifitoxin processing pathway. All are FMN-dependent and oxidize the product of the cyclization of thioesters in short polypeptides.	6.31252e-20
NZ_CP017176.1\|WP_011204702.1\|2093202_2094330_-\|porin	gnl\|CDD\|238208	cd00342, gram_neg_porins, Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers are stabilized by hytrophillic clamping of Loop L2. Loop 3 bends into the pore, creating an elliptical constriction of about 7 x 11A, large enough to allow passage of a glucose molecule without steric hindrance. Removal of the C-terminal residue (usuallly F) destabilizes the trimer and removal of the 16th beta-sheet abolishes trimerization. Unlike typical membrane proteins, porins lack long hydrophobic stretches. Short turns are found at the smooth, periplasmic end, longer irregular loops are found at the rough, extracellular end. C-terminal residue forms salt bridge with N-terminus.	3.6975e-55
NZ_CP017176.1\|WP_004187469.1\|2079961_2080357_-\|conjugal-transfer-protein-TraR	gnl\|CDD\|224648	COG1734, DksA, DnaK suppressor protein [Signal transduction mechanisms].	1.7869e-14
NZ_CP017176.1\|WP_004553972.1\|2083314_2085099_+\|ribonucleotide-reductase	gnl\|CDD\|180772	PRK06948, PRK06948, ribonucleotide reductase-like protein; Provisional.	0

>NZ_CP017176.1|WP_004187469.1|2079961_2080357_-|conjugal-transfer-protein-TraR
MAAFDEHQLQVLGALLRACRQALQADVRAGERQRADEPYANLAGPAPDEGDEANADLFVDVDHALLGMKLAELRDVDAALQRIARRDYGCCADCGQPIAYERLLARPTALRCAPCQRAHERRFATQPRPSL
>NZ_CP017176.1|WP_004187216.1|2077555_2079829_-|pyridine-nucleotide-disulfide-oxidoreductase
MREFDYLLVGGGIASVTAARTLRGEDASASIAILCGEPVLPYQRPPLSQEWLMGAVQPASITLHDAAFYAAQRIDIALGVRAEQLDRAKRIVRTSSGATFRYGKLLIATGASAKAPALPGFGLDGVHVLHTFAQAQALKDAAAHARRATVLGGGFLGVEIAATLQALGLQVTLVERAPGVMPSLRAPALGGHFEALCRARGIDVLTRCEVRRVLGAQCVEAVETSDGGTRPCDLFVAAVGVTPNCGWLDGSGLALGDGVEVDAFLQTADPDVFAAGDVAHFDDPIFGVRRRIEHWDNAVRQGRIAARNMLGHRLPYRDVSIFYGSVFGLSYNLLGYPVGATETIERGAFDEASYMQLYLADDVLRAAFTIDRPAVEIAALNDAIRLHVNVAAHKMKLSDPNYPLDKLPVQTILILQGGGALGAFECGAVKALEQHGVRPDVISAVSIGAFNGAIVASHPKGATKALEAFWRELSIALPLPYESQWREAWLSSYVLSFGVPNFLKPQWSQLGFDADRLRAKWTSFFDATAIEQLIARYVDFDSLGMSPTRLLIGAVDVETGEPRIFDSYVDRLSPAHVLASGSLPPGMPWTVVDGRPYWDGGVVSNSPLDLVIARCGQIGGRVFIVDLFSGSKALPTNLVEVMLRREEIAYMDRVRNDLRFEEYASDFRDLVDGILAHVDAPSANEIRQQPLYIRLMGNRAAIDIARITLNREGRLSFIEDYDFSSDAIAQLQQQGYDAALVALANGRSRRRRGRRRA
>NZ_CP017176.1|WP_011204697.1|2075586_2077245_+|GMC-family-oxidoreductase
MKQQSYDYDYVVVGSGFGGSVSALRLSEKGYRVLVIEQGRRWTPENLPESTWNLSRWQWRPALGLHGFFSMRFFRHVVVLHGNAVGGGSITYANTLLVPPNKVWREGTWAGLEDWERVMPAHYATAKRMLGVVTNRRMDAADFRLKDMAKLIGVEKSFYPTEVGVFFGDDADAPGTRYADPYFGGAGPERTSCIGCGGCMVGCRHGAKNTLDRNYLYLAERLGAQVREQTKVVDVRPLDARADGAAGYAVEAVSLAAGARGAKSRLTCRGVVFAASSLGTQDLLMRLKEKGSLPRLSDALGKRVRTNAESLIGVRFPKSRVDLSKGVAIGSGIYIDEHTHIEATRYPSGSDTMGLLTTVLTRGAPGGLRVLVWLGALAKLVLTRPLSAWRMIDPRGFARETMIFLCMQTLEGHLTMRLKRRWFWPFSKQLATSGAKIPAYIPAANDFAQKAARALGGVPMTSLTEILLNVPMTAHCMGGAAMARDARDGVCDGRSRVFGYRNMYVCDGSVLGANLGVNPSLTITALAEHAMSHVPAAREQRWDSTAETPVAA
>NZ_CP017176.1|WP_011204696.1|2074855_2075287_+|hypothetical-protein
MHQERRKRNADRHGTHPYDADSRAAPREAPRFEHEPKKQRDAAQHEVDRDRAAREIHERIEHKARPDVRRAERPISQDVAQTPIGAAGAISPSTARSIFLEIGLALAGRPIQVRRNRAPFTHGTPRRRPARGPTARTASPAPV
>NZ_CP017176.1|WP_004205322.1|2073738_2074674_+|LysR-family-transcriptional-regulator
MIQNLRQLDLNLLLVFDALMQEQNLSRAAIRLHMSQPAVSNALTRLRQQLGEPLFTRTARGMTPTAQARTLYEPVRQALYLLQIGLGPQADFEPDTHHLFKLSMNDYGQTVLLPDLLAHIKSRAPNVMLSVQSDDAGSIPAQLTTGTLDLAIDYLHFDNPELCYEPLHEEHLVVIGRAGHPAFAGGLALRGYEESGHVSIQPRDRRGSPLEIVLGSARVRRVVHLQVPHYLTIPALVAKSDLLGTIPRRLAERFADVYALQIAPLPIDIAPIQVSLIWHRQQDAQPGLRWLREQVVLTHRAIIGCGEHAPA
>NZ_CP017176.1|WP_009927403.1|2073501_2073612_-|hypothetical-protein
MQSTGSFDISARRMIEFRSVNKSNHDCPLEKSSGLL
>NZ_CP017176.1|WP_004200700.1|2072325_2073441_-|hypothetical-protein
MTQDVTVFRARYRASVHPRYNAWLHGGFVLAYGCAAIAFFLKDVARVSAVQWASVPAAFLLFNWLEFTVHRHVGHVKRRFGAMFYRRHTGDHHSFFANEQIAYREARDWRVILFPAWLIVVFSLGLFALHAVLGRFDANVAGLFASTMLGGYLLYECVHACEHLPDAHPLAKWPWIRQMRVLHRVHHRDALMRSCNFDVIWPLMDWLHGTLRWSEAPGADMSTRMRHEIDIACAGADVLAYASDASRWPEWHPSSLRVDGPAGSLAAGSRFDEDVRAAGRVDRLHWDVVRNEPGVMWQARAANTAGSLRILLTYECSGGPRGARFVRTLHYHSPNPLLRLANALVMRGRVERESAYSLTLLKRRLEAARDA
>NZ_CP017176.1|WP_004196898.1|2071550_2071991_+|SRPBCC-family-protein
MKQQRIEIAEEFDAPVHQVFRFFSEHENLKSIFSPAKIRRISDGEPARNGVGSAREMRVPGAPPFVETVTAYQENELIEYRITRGSPLRDHLGVMRFVPIDERRTYFHYVITFEGKVPFVAPVVRHVLEGSIRRGLGKVATRRLWG
>NZ_CP017176.1|WP_009950893.1|2071159_2071465_-|hypothetical-protein
MRHDSRLRCTRDDDDIDQCHRQSGRSPLDAEPNRGCAARRLRASGGRRPRGANTEPRRRKPHARVIRQRSWRAARTRPCRRFSAACGRFGQAMARRARPPA
>NZ_CP017176.1|WP_011204695.1|2070501_2070828_+|hypothetical-protein
MRHACRACGPRVRRTRFCAMRKRSETHGRSLSLSLAHRATDARCARCPHSRHELCTRARAPARERRRCIASRISLITTINFRAVAFRPRLPKHYIDRWNHRSAGTPAA
>NZ_CP017176.1|WP_004188034.1|2081743_2083009_+|polyhydroxyalkanoate-depolymerase
MLYAWLEAQREFFRACQPWAGAAQRAGAGARPAGWPTWGPMARAADAVPAPPPFAIASIEIDGAAVPVDECVVDDTPFCALRKFSRRLRGDAAARPAVFLCTPLAGHHAVMLRETVETILATRDVYVTDWRNARDVPPEAGAFGLDDYVCTLERFVAGAAGDGLHMMAVCQATVPALAAVALLAARDVHVTSVALLGGPVDTRSHPTLIDRFALEHDLDWFRRTAIDIVPPPYAGAGRRVYPGFIQHAAIIVAHPQRRASLESRYWTAWMTGDFAAAARCLREMNEYGAVLDMTERYFLDTIRVIFHERLLAQGRWSIGRRLVAPRRLTRTALCTIEGGRDDIAGAGQTHAAHALCDAVPDAVRERITEPDCDHYDLFLGPRWRRTIHPALDAFWTRAEAARAAAGEPRPTAERAERRIAH
>NZ_CP017176.1|WP_004553972.1|2083314_2085099_+|ribonucleotide-reductase
MIGDMDDQPICDAVFADRYALPGEHSRAQACARVARALALAEPMATRSGAARRFYRNLLNGAFGAGRIMARAGAAPDQTMASCFVHPIRAPAALTRFHPNLDEALDEARLALAMGADIGYDFSAIPPAGARPDADHPDSPGVCAALDRFDRIGTQAGERDGRRRAQLAVLRCDHPDLLAFAAAKHRHAGRHARWTTLELAVAATDAFMQAVEQDLPWTLRHTAPPRDAPGGALPGADGAWTYASVPARHVWREIVSAARDGAGPGLVFVDAIDAADPLRGRERIDATSPCGAQPLPPYGSAMLGAIDLSRFVRNPFGAGGEPRFDFAAFDTAVRIEVRLLDNALDVTRWPLAAHARESYQKRRIGVGVTGLADMLAMMRLRYDSPAAREMARYIASDLRHHAYAASAELAAERGAYPLCDRHAHLDALRAGPPLPHAVCHAIERDGLRHSHLTSFAPVIGVSLAFGDHCSPGIEPARAWIEHRPVRAGAAGAPGMRAENHAHRLFRSLRGERAALPDYFATDADVAPGERLAMRVALQPYVDAGIDNTLTLANHYSLEEVNALLFAAWRAKLKSVAIRRADLARDAQPSDDDGV
>NZ_CP017176.1|WP_004187710.1|2085173_2086976_+|bifunctional-aminoglycoside-phosphotransferase/ATP-binding-protein
MTTGAVAARRLPRRGTARGRRAPSRAFTIHGGDEMRRSRPPKPAKPAAVRRRPHGAARAHAIRGNGPQRRAVRERAARRLSRDIDAALRRASTYPHPAGPIVRIETHLSVVYLVGRFAYKRLKPFDFGFANFTELAARRRACEAELALNRPLAAPIYLAAGPLVRRARGLRLFGAGAAVDHVVRMRRFDERMLFSRLLARGALDAADIDAAATRLAAYHLHAPRDIPRRAYGSARELRRQLDDMLAPLERALGAALPASLRAWCVRRCDELAAHLDARRADGYVRACHGDLHLNNVVKRGRDALMFDCIDFDDALRWIDVINDLSFLLMDLHAHDRAALAHRLLNRWLDETGDFAGLAALPLYVAYRALVRALVATMRAGGDAAARAARIERARRYVDVAAHAARARRPCLLLCHGYSGSGKSVASRALADVSGAIRLSSDSERKRARPFAAVDARPLPASAYTPQQIDAQYERLRALARDVLRAGYTALVDATFLSHARRARFFALARELGVPVYVLDFHASRACLERRVDARAAARDDRSDAGAAVLATQRASADPLDADERARTIGFDTDVPLATLRSAGYWRPVLDAARVDAQATR
>NZ_CP017176.1|WP_004187305.1|2087498_2088530_+|hypothetical-protein
METSPLKTTTPEAIPPFNPSASVEDKLRLAIHYAILAPSSHNTQPWRFMVGDGSVMLCADRLRALSVVDPYDRELLISCGAALLNLRVALSRFGFAYVIDMFPSPSDPDVIALVRLDPHGYHDESLVPLFDAILERVTTRTPYANEAVPCDVQRALVDAGAAEGAEIACVDAPHALDEIAELIADADRLQFADPRFRRELANWVHPRRHDDGMPAFAAGVPALLDFATPVVASAIRTFDLGGGLAAMHHKLVDGSPLIVGISTASDDRDAWVATGQALERVLLVAAAAGLTASYLNQPIEIDALRERLRPLLHVDAHPQLLLRIGRGPVVAHAPRRPLMDVVS
>NZ_CP017176.1|WP_004187792.1|2088526_2090359_+|STAS-domain-containing-protein
MTERERAARGRNDARRGGGDSGGDDEAWRRWLPGIATLRTYRRAWLARDLYAGVALTAVLVPVGMSYAQAAGLPVIAGLNASIAALVGYAIFGPSRILVLGPDSALAALIAGAIAPLAHGEPAHAVALAAALALMSGGFCVLAGLLKLGFVTDLLSKPIQYGYLNGLALTLIASQLPSLLGTVPLGGTFVDQVASLAATVAQGRIDFASLALGGGCLAGIALLRRVAPAWPGMLIAVAGASIVAAWLGAAPDAGGAHAHVAYAHVANAHVALVGSLAGTLPPLGLPSISLADASRLIAGALAIAMVSVADISVLSHVFAQHDGSETDRNQELCALGAANLLAGMLRGCAVSSSASRTPVALAAGARTQLTSLVAAACIALLLIAPTLLARVPLAALAAVVVYSANALVDVRAIVRLYRVRRGECAVSVLCFAGVVLLGVVPGILLAVGLSLLSFVWRAWHPYDAVLGRVEGMHGYHDVSRHPGATLTRGLVAFRWDAPLFHANATIFRDHVRDAIAEAGAPVRCVVIAAEPITDVDVTAADMLATLRDELAARRIALVFAEMKGPVKDRLRTYGLFEKIGADHFFPTVTDAIEHFTRMRKDVATARRARR
>NZ_CP017176.1|WP_011204700.1|2090391_2090766_+|hypothetical-protein
MRARAPIRLGGSARLRSVDDDGAGAQAIEAVRRRHGIGHHDAVSVNAAQAARLRAVARTPNCALDRLDAARFAALRIDDVDISVAVALGIDINVAFPLDIDIDATRRETRRDDSIRQSRAFSSK
>NZ_CP017176.1|WP_004187137.1|2090738_2091188_-|CBS-domain-containing-protein
MNAAEICTREVVACRRTDTVLDAAHLMRDRHVGDLIVVDDAGHAHAPVGMLTDRDIVLSLIAKEVDPAALFVGEIMSAPAAVVHEHDSLWTIAQRMRLTGVRRMPVVNADGALVGMVSVDDLLASVAALFDEIASISRRQIHFEEKARD
>NZ_CP017176.1|WP_004200705.1|2091641_2092295_+|SagB/ThcOx-family-dehydrogenase
MSDPELLTYQPIAVALPGPAEAGAPAVIDLPPPDLGAGLPLMSALSLRASTREFSSAALAPTTLGELLWAADGVNRPTTGGRTAPSAHAFNEIDIYAALPDGVYRYDAALHRLLLKHAVDARNLTGYQDFVGAAPLDLIYVVRMSRLLSMPKPLRETFSAVAAGAIAQNVALYCASTGLGCVVRGWINHRLLAEALSLNEDELPILAQTVGKPAAHP
>NZ_CP017176.1|WP_011204701.1|2092362_2092797_-|Hsp20/alpha-crystallin-family-protein
MSNVTRYDPFSLEPVSDLFRGLFRPLRGIADADDEKLASMKIDVTENDQAYAVKAELPGVDKNDINVQIDGNTVSISAKVERNKELKEGERVIRRERYSGEFARTFSLANELDRDAASAQYQDGVLSLTLPKKASSEKKKLTIG
>NZ_CP017176.1|WP_011204702.1|2093202_2094330_-|porin
MNAKSIAAAALAVAQAGLAHAQSSVTLYGALDAGVLWQNTSAASFSPTAPNTGAVVRFKDGGVYSSLWGIKGTEDLGGGYRVNFRLQGAFDGGTGKFGLSDAPGAVAAFNQIATLGVSGPFGTFNAGRQIVPMIYAMADTDVRAARFFGSVLTAWLGLNTAAGWPGNSTNAPIGALYDSDALVYQSPAFGGASLALEYAPGGVPGGVQRGARASIVLKYASNALNLAAVYYNGHDTNPAPGASATGLDNNRFVYVGAQYKLKDVAVSASYGNGRNPARGDRVNLDMFAFGLGYRVSPFFRVSSGVYYLKDRNRSANRSTSIVLGADYELSKHTTLYAQGGRVDNRGTMAQMLAYGQPVAPGLATTAAMLGMRHSF

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Crispr_ID: NZ_CP017176_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017176_2

2177204-2177296

Orphan

Consensus_repeat	Method
GCGCGTCGGCGCGCGCGGCGGCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017176_2

>merge|NZ_CP017176|2|2177204-2177296|CRISPRCasFinder
GCGCGTCGGCGCGCGCGGCGGCGATCAGCCGCTCGCGCTCGGCGGCGGCCTGCGCGAGCGCGTCCTTCAGCGCGTCGTCGCGCGCGGCGGCGA

>NZ_CP017176|2|2|2177204-2177296|CRISPRCasFinder
GCGCGTCGGCGCGCGCGGCGGCGA	TCAGCCGCTCGCGCTCGGCGGCGGCCTGCGCGAGCGCGTCCTTCA
GCGCGTCGTCGCGCGCGGCGGCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017176.1\|WP_004198322.1\|2172090_2172594_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017176.1\|WP_004188840.1\|2181656_2183450_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|213656
NZ_CP017176.1\|WP_004188221.1\|2179246_2179702_-\|F0F1-ATP-synthase-subunit-epsilon	unknown	unknown	gnl\|CDD\|184057
NZ_CP017176.1\|WP_004188073.1\|2179691_2181296_-\|F0F1-ATP-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|183615
NZ_CP017176.1\|WP_004187346.1\|2177759_2178461_-\|F0F1-ATP-synthase-subunit-A	unknown	unknown	gnl\|CDD\|237383
NZ_CP017176.1\|WP_044302747.1\|2169417_2171022_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|185008
NZ_CP017176.1\|WP_004187158.1\|2171523_2172033_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017176.1\|WP_004198321.1\|2172670_2173696_-\|alcohol-dehydrogenase-AdhP	unknown	unknown	gnl\|CDD\|176257
NZ_CP017176.1\|WP_004188438.1\|2178758_2179250_-\|AtpZ/AtpI-family-protein	unknown	unknown	gnl\|CDD\|378198
NZ_CP017176.1\|WP_069605647.1\|2162743_2165950_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP017176.1\|WP_004188303.1\|2173910_2174759_-\|F0F1-ATP-synthase-subunit-gamma	unknown	unknown	gnl\|CDD\|376304
NZ_CP017176.1\|WP_062880472.1\|2174755_2176768_-\|F0F1-ATP-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|183987
NZ_CP017176.1\|WP_004198323.1\|2169167_2169326_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017176.1\|WP_004187423.1\|2181267_2181525_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017176.1\|WP_004187193.1\|2177514_2177763_-\|F0F1-ATP-synthase-subunit-C	unknown	unknown	gnl\|CDD\|184067
NZ_CP017176.1\|WP_004188458.1\|2184860_2186039_+\|acetate/propionate-family-kinase	unknown	unknown	gnl\|CDD\|235922
NZ_CP017176.1\|WP_011204278.1\|2183433_2184864_+\|bifunctional-enoyl-CoA-hydratase/phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|236180
NZ_CP017176.1\|WP_004188525.1\|2165952_2167077_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912
NZ_CP017176.1\|WP_004201694.1\|2178457_2178766_-\|membrane-protein	unknown	unknown	gnl\|CDD\|274462
NZ_CP017176.1\|WP_004187376.1\|2167226_2169062_+\|response-regulator	unknown	unknown	gnl\|CDD\|237425

Protein	Function_ID	Function_description	E-value
NZ_CP017176.1\|WP_004188840.1\|2181656_2183450_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|213656	TIGR01838, Poly-beta-hydroxybutyrate_polymerase, poly(R)-hydroxyalkanoic acid synthase, class I. This model represents the class I subfamily of poly(R)-hydroxyalkanoate synthases, which polymerizes hydroxyacyl-CoAs with three to five carbons in the hydroxyacyl backbone into aliphatic esters termed poly(R)-hydroxyalkanoic acids. These polymers accumulate as carbon and energy storage inclusions in many species and can amount to 90 percent of the dry weight of cell. [Fatty acid and phospholipid metabolism, Biosynthesis].	6.3979e-179
NZ_CP017176.1\|WP_004188221.1\|2179246_2179702_-\|F0F1-ATP-synthase-subunit-epsilon	gnl\|CDD\|184057	PRK13447, PRK13447, F0F1 ATP synthase subunit epsilon; Provisional.	4.44077e-63
NZ_CP017176.1\|WP_004188073.1\|2179691_2181296_-\|F0F1-ATP-synthase-subunit-beta	gnl\|CDD\|183615	PRK12597, PRK12597, F0F1 ATP synthase subunit beta; Provisional.	0
NZ_CP017176.1\|WP_004187346.1\|2177759_2178461_-\|F0F1-ATP-synthase-subunit-A	gnl\|CDD\|237383	PRK13421, PRK13421, F0F1 ATP synthase subunit A; Provisional.	1.54059e-122
NZ_CP017176.1\|WP_044302747.1\|2169417_2171022_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|185008	PRK15048, PRK15048, methyl-accepting chemotaxis protein II; Provisional.	2.56608e-79
NZ_CP017176.1\|WP_004198321.1\|2172670_2173696_-\|alcohol-dehydrogenase-AdhP	gnl\|CDD\|176257	cd08297, CAD3, Cinnamyl alcohol dehydrogenases (CAD). These alcohol dehydrogenases are related to the cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Cinnamyl alcohol dehydrogenases (CAD) reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH- dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0
NZ_CP017176.1\|WP_004188438.1\|2178758_2179250_-\|AtpZ/AtpI-family-protein	gnl\|CDD\|378198	pfam09527, ATPase_gene1, Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter. This model represents a protein found encoded in F1F0-ATPase operons in several genomes, including Methanosarcina barkeri (archaeal) and Chlorobium tepidum (bacterial). It is a small protein (about 100 amino acids) with long hydrophobic stretches and is presumed to be a subunit of the enzyme. It carries two transmembrane helices and is a magnesium or calcium uniporter. The atp operon of alkaliphilic Bacillus pseudofirmus OF4, as in most prokaryotes, contains the eight structural genes for the F-ATPase (ATP synthase), which are preceded by an atpI gene that encodes a membrane protein with 2 TMSs. A tenth gene, atpZ, has been found in this operon, which is upstream of and overlapping with atpI.	7.77353e-17
NZ_CP017176.1\|WP_069605647.1\|2162743_2165950_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.27379e-92
NZ_CP017176.1\|WP_004188303.1\|2173910_2174759_-\|F0F1-ATP-synthase-subunit-gamma	gnl\|CDD\|376304	pfam00231, ATP-synt, ATP synthase.	1.10329e-32
NZ_CP017176.1\|WP_062880472.1\|2174755_2176768_-\|F0F1-ATP-synthase-subunit-alpha	gnl\|CDD\|183987	PRK13343, PRK13343, F0F1 ATP synthase subunit alpha; Provisional.	0
NZ_CP017176.1\|WP_011204278.1\|2183433_2184864_+\|bifunctional-enoyl-CoA-hydratase/phosphate-acetyltransferase	gnl\|CDD\|236180	PRK08190, PRK08190, bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated.	0
NZ_CP017176.1\|WP_004187193.1\|2177514_2177763_-\|F0F1-ATP-synthase-subunit-C	gnl\|CDD\|184067	PRK13468, PRK13468, F0F1 ATP synthase subunit C; Provisional.	4.45015e-37
NZ_CP017176.1\|WP_004188458.1\|2184860_2186039_+\|acetate/propionate-family-kinase	gnl\|CDD\|235922	PRK07058, PRK07058, acetate/propionate family kinase.	0
NZ_CP017176.1\|WP_004188525.1\|2165952_2167077_+\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	6.54035e-26
NZ_CP017176.1\|WP_004201694.1\|2178457_2178766_-\|membrane-protein	gnl\|CDD\|274462	TIGR03165, F1F0_chp_2, F1/F0 ATPase, Methanosarcina type, subunit 2. Members of this protein family are uncharacterized, highly hydrophobic proteins encoded in the middle of apparent F1/F0 ATPase operons. We note, however, that this protein is both broadly and sparsely distributed. It is found in about only about two percent of microbial genomes sequenced, with the first ten examples found coming from the Euryarchaeota, Chlorobia, Betaproteobacteria, Deltaproteobacteria, and Planctomycetes. In most of these species, surrounding operon appears to represent a second F1/F0 ATPase system, and the member proteins belong to subfamilies with the same phylogenetic distribution as the current protein family.	3.23546e-10
NZ_CP017176.1\|WP_004187376.1\|2167226_2169062_+\|response-regulator	gnl\|CDD\|237425	PRK13557, PRK13557, histidine kinase; Provisional.	2.51413e-132

>NZ_CP017176.1|WP_062880472.1|2174755_2176768_-|F0F1-ATP-synthase-subunit-alpha
MTPTPDAPAAADAATGAGWLARRRGALARVALAPIAQAIGRVERVADGIAFVSGLEDTMLNEVLRFEGGVTGFAHTLDEDLISVVLLDPDAGVRAQTAVARTGAVLEVPAGPQLLGRVVDPLGRPLDGGAPLDAAHTLPIERAAPAIIERDLVSEPLDTGVLIVDALFTIGRGQRELIIGDRATGKTSLAIDAIVNQRHSDVICVYVAIGQRASAVRRVIDAVRRYGAPERCVFVVAPAACAPGLQWIAPFAGFSIAEYFRDRGQHALVVVDDLTKHAATHRELALLTREPPGREAYPGDIFYVHARLLERAAKLSAALGGGSLSALPIAETDAGNLAAYIPTNLISITDGQIVLDSALFAANQRPAVDVGLSVSRVGGKAQHPALRAASGRLRLDYAQFLELEAFTRFGGLTDARLRAQITRGERIRALITQPRFRALRTLDEVVLLKALAAGTLDVMSPDLVAPLRERLPAWLDARIAALTPALAPPRDWLADDAALDALAESVGELIERIAADAARRATAGMPAEDAAGDIGGAFGGEQARGDADRDADHGANREVSREVSPEASREVSREVSREVSHEADRDAAADAARVAGRAPGRAEPDRAVPRAMPDGPPRAQADGDRASASRPPPDARGDAARTAPSPQGGADANVNADANVDAEAEARHKR
>NZ_CP017176.1|WP_004188303.1|2173910_2174759_-|F0F1-ATP-synthase-subunit-gamma
MSDKLAAIEARTDTARQLQTVIGAMQGVAAARAHEAQQRLPGIRASAATVGAAIGDALSAGARSGETAAGARAAPRARFVVVLCSEQGFVGAYNAQLIEHATRPGPSVSREYMMVGSRGAMLADAGGVPLVWRTPMAARADDVVHLANRITDALYAHLAKRGAQPVSIVHAMPGGAARLEVTERRLLPFDYARFDTAPRAQPPLVHLPPATLLAELAQAYVFVELCEAAMLAFAAENEARTRAMIAARESVERALGDLLQAYRIARQDEITADIVELAASGL
>NZ_CP017176.1|WP_004198321.1|2172670_2173696_-|alcohol-dehydrogenase-AdhP
MAQYMKAAVVHAFGEPLRIEEVPVPTPGAGQILVNVKASGVCHTDLHAADGDWPVKPTLPFIPGHEGVGFVAAVGEGVRHVKEGDRVGVPWLYTACGHCEYCQTGWETLCHEQQNTGYSVNGSYAEYVLADPNYVGHLPSNVAFDEIAPILCAGVTVYKGIRVTDTRPGQWIAISGIGGLGHVAVQYAKAMGLHVVAVDVAPQKLELARKLGATFVVDASKDDPAAVIQKEIGGVHGVLVTAVSRGAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESLDFAAEGLVRAHIHRDKLEHINGVFSALREGKVDGRIVLTGQ
>NZ_CP017176.1|WP_004198322.1|2172090_2172594_-|hypothetical-protein
MRGAGRASPSRARRYENVSKEPNTHREAGAPVHRYRLQVRNMNGECRTYELRLSSLDDGYTLEIDEWLNFPDTHLGDVTPVHVSRPVQFAVPAHEFYRRRRAFRTELIESVAAALRAGEVVRMRDSPDEYPGGHAGNPWVNWIRADLRANPGGRPPPVGDDMQDLIH
>NZ_CP017176.1|WP_004187158.1|2171523_2172033_+|hypothetical-protein
MRRIYFLLPDADTARAIVDELLLKRIEWRHIHVVANDRVPLENLPEASIAQSSDLLPALARGTAADGVTGALAGLAAIAFPPAGLTIAGGAVVAFAIAGAGFGAWVSTMIGVSVPNTRLKHFEDAVDNGELLMMIDVHRDRVEEIEALVKQHHPNAHLEGTDPTIPAFP
>NZ_CP017176.1|WP_044302747.1|2169417_2171022_-|methyl-accepting-chemotaxis-protein
MAPFHRRTTRNARTPTLSFRQKLWLPLVISLIALLLVSISSAWLSYQTRMEERRNDLTNVAHVGLSIVREYAALAQRGVLTDAQARKEALERLRSVRYGSDGYFIVIDSSPRMIMHPIKPDTVGKDLRHVADADGRHHYLTFASVAQSPQGGFVDYVFAHPNAHPAKAVDKLGYVIRYAPWDWIISTGAYIDDIQAAFAKSLCLSAGVFALLAALLALSVVYTNRGIERMIGGDPRIAAHMAGVIASGDLATPFATRREDRSSLMFAISQMRDALANAVAQIRASAGYVATTAGEIADSNMDLSSHTECQATALQQAASSMQRLTERVRDTADRARAASELAGSAARITDRGGDMVVRVVAAMNDIRAESRKMVDIIGVIEGIAFQTNILALNAAVEAARAGNEGRGFAVVASEVRVLAQRSASAAKDIRALIGRAAERVGNGAELVEATGATIGEAQHAICRVTGIVQDIAAAATDQSQGLEQINAAVSQMDSVTRRNATLVEHAAIAAQSLNEQSRCLQDAVAAFRTEALGC
>NZ_CP017176.1|WP_004198323.1|2169167_2169326_+|hypothetical-protein
MRARRSHGAGIRLGFDKPSGTHSSPHDGWVQTDIAMRLPQISLMPDQALANE
>NZ_CP017176.1|WP_004187376.1|2167226_2169062_+|response-regulator
MHVEVFAQHPSCPGWHGEMARRIRAFDWSATELGPLERWPASLVAAVRTVLASPVPLVMLWGASGYMLYNDAYAAFAGGRHPYLLGQPVELGWPEVADFNRNVMRTCLAGGALSYRDKALVLLRNGRPEEVWMDLYYSPLAGDDGAPAGVLAVVVETTERVLAARHRDRAKAALHETNAELRRLTETLEQRVADAITERASIEEQLRQAQKMEAIGSLTGGIAHDFNNVLQVVSSNLQMLSAELGEDARAQRRIASAANAVARGAQLASHLLAFARRQPLAPAVLDPRGLIDGMREMLHRALGESVHVDADLRDDVWNVLADRHQFENALLNLAINARDAMRGEGTLKITACNIVLEAGRHARRNGLPPGEYVAFDIADNGVGMTPDILERVFEPFFTTKPDGQGTGLGLSMVFGFVKQSGGHTSIESAPGRGTTVRLLLPRCREAPAGEPAAQRRLPAEGGRETILVVEDDADVRLAVVDMLAQLGYKVITASDGEAGLLALESGAPIDLLFTDVIMPGRIKGGELARRAAQRVPPVPVLFTSGYTRDEIFHAGRLDPGVMLLGKPYRRDELAHKVRSVLDAHASARRAHGARHAQADPRAKTAAARVQR
>NZ_CP017176.1|WP_004188525.1|2165952_2167077_+|ABC-transporter-permease
MRRLAIIYRLGVKELWSLVRDPILLVLIAYTFTASIYSAATARPDTLHMAPIAIIDEDASPLSARIASAFFPPQFALPRMVTLAEADRGMDAGDFTFALDIPPNFQRDVLAGRPAQIQLNVDATRMSQAFTGNGYVQQIVSGEIDDFARRYRANTAPPVDIAMHMRFNPNLDQTWFGSLMEVINNVTLLSMVLTGAALIREREHGTIEHLLVMPVTPGEIMLAKVWSMGLVVACAAAFSLAFVVRGALHVPIEGSVALFVIGMAIHLFATTSMGIFLATLVRSMPQFGMLLVLVLLPLQLLSGSLTPRESMPFAVQNIMLAAPTTHFVEIGQAILYRGAGIETVWRQFLILAVIGTALFLLSLKRFRKTIGQMA
>NZ_CP017176.1|WP_069605647.1|2162743_2165950_+|ATP-binding-cassette-domain-containing-protein
MSAPSVVRFSDVSLRYGKTVALERITLEIPAGLTIGLIGPDGVGKSSLLALAAGARALQTGAVDALGGDMRSRRHRERVCRRIAYMPQGLGKNLYPTLSVEENLQFFARLFGHDADERRRRIDALTRSTGLFAFLSRPAGKLSGGMKQKLGLCCALIHDPDLLILDEPTTGVDPLARAQFWDLIARIRSERPAMSVIVATAYMDEAQRFDWLIAMDAGRVLATGAPAELLARTGCDSLEAAFIALLPEDERRGHKPVTLEPLRADAQTGTAIEARGLTMRFGDFTAVDHVSFRIRRGEIFGFLGSNGCGKSTTMKMLTGLLPATEGTAQLFGKTVDPKDINTRRRVGYMSQAFSLYSELTVRQNLVLHARLFGVPAAEIDARVDEMARRFGLADIYDMLPDSLPLGMRQRLSLAVAMVHKPELLILDEPTSGVDPVARDSFWQLMIDLARRDRVTIFISTHFMNEAQRCDRISLMHAGRVLASDAPAALVRARGAATLEEAFIGYLVDASAQEAQGGAGERPGAGERAAGESVAGRGAATDGDADGAHARPAAYANGAAQHRAPDADAAGTDVAAETGARDDARTAHAAGHSAGNDVRATVGSEVGSEVASEAGLAASAESGSERGVAHGAERAREPAADAGAAIDVEPGASAESATAAVAPARHAESAATSPRAGNAPAGTPFAAAPAEPPHRAFSAQRALSYMWREMLELRRDPVRATLALIGSLVLMCVIGIGISLDVEDLTYAVLDRDQTELSHDYALNLSGSRYFVERPPIADYAALDRRMRDGELSLAIEIPPNFARDVERGAPAQIGMWIDGAMPQRAETIRGYAIGMHTMWLADKARHRLGVTLAPRAEVVTRYRYNPDVKSLPAMIPAVMPLLLLMLPAMLTALAVVRERELGSILNLYVTPVTRTEFLIGKQVPYVVLAMLNFLLMTMLARIAFDVPVKGSFMTLLLAVLIFNVVATGIGLLASTFTRSQVAAIVMTIIGTMIPTVQFAGLLTPLSSLEGTGRLIGLVYPATYMLSISRGVFNKALSLHELYSQFWPLAACVPVILGATILLLKKQER
>NZ_CP017176.1|WP_004187193.1|2177514_2177763_-|F0F1-ATP-synthase-subunit-C
MNNLIEVVSIAAAALAVSFGAIGPALAEGRAVGAAMDAIARQPDASGTVSRTLFVGLAMIETMAIYCLVVALLLLFANPFVK
>NZ_CP017176.1|WP_004187346.1|2177759_2178461_-|F0F1-ATP-synthase-subunit-A
MNASPLSTVPLFSVGPVGISAPVLATWAIMAVLVALALVARRRLSVDAPSRLQSVLELFVATVDAQIADTMQTPPARYRALIGTIFVLVFCANGASLVPGVEPPTAHLETDAALALVVLAATLYYGVRARGVRGYLATFAEPTWVMIPLNVVEQLTRTFSLIVRLFGNVMSGVFVIGIVLSLAGLFVPIPLMALDLLTGTVQAYIFMVLSMVFIGAAVSGDETSAPRRGQENT
>NZ_CP017176.1|WP_004201694.1|2178457_2178766_-|membrane-protein
MIEMWETARASFDGIAAAIGLALGFAAGACHFVSLGWNSRLFVAGRAGVALALQFARVALAVAVLVVLARAGFGMLVAGSAGFFAARAIAVRRAAALTGARR
>NZ_CP017176.1|WP_004188438.1|2178758_2179250_-|AtpZ/AtpI-family-protein
MMKRRPPEVKREARDDAARGDARHAGAGAAPDDPRGAARRDPSPGSRAARGGATHPAARAAEPAAPKPAADRVERAAHTAAARAARGARDPEPSLGRRLAQIGVLGWTIVAPTLAALALGRWLDRMFATRVFFSAPLLMLGAALGLWLAWRWMKAQQHGDRDD
>NZ_CP017176.1|WP_004188221.1|2179246_2179702_-|F0F1-ATP-synthase-subunit-epsilon
MGAELRVTIATPARVCVDDLPIVSLRAEDASGAFGIRAGHVDFVTLLRASVVRWRTADGATHYAALDGGVLRVTRGARIEIACRDAVLGESLAELEAVVRGVRATQLDEKRRARVDETRLHAQAVRRLLTYLRPEHAKDGVHAPLKPETLE
>NZ_CP017176.1|WP_004188073.1|2179691_2181296_-|F0F1-ATP-synthase-subunit-beta
MADPQATNGTGAVCAERDASDVGDVSDVGDARDEGAGRVVAVRGAVVDVAFDGGALPALNEALTIPVDGAAPILAEVHAHLSDAAVRALALGPTGGLRRGAAVRATGGPIRVPVGDAVLGRLLSVTGAPGDDGAALAADVERRPIHRGAPLLAEQKSANALFATGIKVIDLLAPLAQGGKAAMFGGAGVGKTVFVMELIHAMVERYRGISVFAGIGERSREGHEMLLDMRGSGVLGRTVLVYGQMNEPPGARWRVPLTALAIAEYFRDERAQNVLLLMDNVFRFVQAGAEVSGLLGRLPSRVGYQPTLASEVAALQERIASVEGAAVTAIEAVYVPADDFTDPAVTAIAAHVDSMVVLSRAMAAEGMYPAIDPVASSSILLDPLVVGEAHVEVAIEVRRVIEHYRELQDVIALLGIDELGADDRRLVGRARRLQRFLTQPFAVTEAFTGQAGASVEIADTIAGCRAILRGDCDDWRESSLYMVGTLDDARRKEAAAREADARREAAAAASGAGPGTTSDPASGSAEPQGARHGR
>NZ_CP017176.1|WP_004187423.1|2181267_2181525_+|hypothetical-protein
MPFVACGSATVAPVWLVRRWLHHNGARRPPADLGQETGNRQTKRGIAQSETIDASASGADKVRAASIVDSNQIPQTYAWLQWPCQ
>NZ_CP017176.1|WP_004188840.1|2181656_2183450_+|alpha/beta-fold-hydrolase
MDTRHAPESGAPDAPLPAHPPASYAPESPYRIFDLAKEASVAKLTSGLSPASLQLALADWLIHLAAAPGKRAELATLALRHAALLGQYLLEAATGRTPAAPAQPSPGDRRFRAGAWQLEPYRFWHQSFLLAEQWWRAATRDVPGVSPHHEDVVAFSARQMLDTFAPANYVATNPEIAQRTALTGGANLAQGVWNYLDDVRRLITKQPPAGAEQFELGRNLATTPGRVVFRNHLIELLQYSPTTPDVYAQPVLIVPAWIMKYYILDLSAHNSLIRYLVGEGHTVFCISWRNVDASDRDLSLDDYRKLGVMDALDTIGAIVPGEKIHATGYCLGGTLLSIAAAAMANTGDDRLASITLLAAQTDFAEPGELQLFIDDSEIHFLESMMWERGYLGAHQMAGSFQLLMSNDLIWSRVIHDYLLGERTPMIDLMAWNADSTRMPYRMHSEYLRHLFLDNDLATNRYVIDGQTVSVHNIRAPFFVVGTEHDHIAPWRSVYKIHYLSGSDVTFVLTAGGHNAGIVSEPGHAKRHYRMKMTAAAAPSISPDEWLAGATDFEGSWWPAWHAWLARHSSPQRVAPPPLGKPGAHTLGDAPGTYVFQK
>NZ_CP017176.1|WP_011204278.1|2183433_2184864_+|bifunctional-enoyl-CoA-hydratase/phosphate-acetyltransferase
MCSRNKECRVDREILQNRPFDSLAIGDSASLVRTASRDDIDLFAAMSGDVNPAHLDAAFAAHDLFGHVVVHGMWTGALVSAVLGTKLPGPGTIYLDQTLEFRHPVAPGDTITATVTVAEKRPEKRIVLLDTRCTNQDGHVVLRGTATVIAPDTPITWERVPGPEVAVRRHDRYETFVRDAREQPPLRTAIVHPCSPDALRAAIDARDANLIEPILIGPQAKIRAIADAAGVDLAGVPIEAVEHSHAAAARAVEMGGAGEVAALMKGSLHTDELLAAVIGPASRLRTERRISHVYAMDVPAYPKPLLITDAAINIAPTLEQKRDICQNAVDLLHVLGVERPRVAVLAAVETVNPKMPSTLDAAALTVMAARGQIAGAIVDGPLAFDNAVSAVAAMSKGIASPVAGDADVLLVPDLEAGNMLAKQLMYFAGADAAGLVLGTRLPIILTSRADSLRVRIASAALAKLVAERTRAGALAS
>NZ_CP017176.1|WP_004188458.1|2184860_2186039_+|acetate/propionate-family-kinase
MSEPLLLTFNAGSSTLKIGLYSVANGEPAPLGRGKIDFNRAPLQFEYANGGEAHAVPLAAPVTDDLHAVLDEALGWIDAHLSVHELVSVGHRVVHGGDTFDGPVRIDERTLDAIAALVPLAPLHQPQSVRLIRALRHVRPHLPQVASFDTAFHRTQSDLVRRFALPRALFDAGIKRYGFHGLSYRYVAGRLRERHPSIARGKVVAAHLGSGASLCALDAGVSRDTSMGFSTLDGIPMATRCGALDAGVVLHLQKTLGRTLDDVEQMLYHRSGLLGVSGVSGDARALLADPSAGARDALELFAFRIAGETARLAATLGGLDALVFTAGIGEHQPQTRAAVCERLRWLSVELDAHANARNAETVSRDGSRVAVLVVPTDEEQVIARDAASVLHA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

342391 : 389052

Leptospira_phage(33.33%)

plate,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004190585.1\|342391_343795_+\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_004190689.1\|343810_345127_+	DotU family type VI secretion system protein	NA	NA	NA	NA
WP_004190681.1\|345129_348759_+	type VI secretion system membrane subunit TssM	NA	NA	NA	NA
WP_004190273.1\|349655_349883_-	hypothetical protein	NA	NA	NA	NA
WP_004190797.1\|349881_352479_+	protein kinase	M1I231	Acanthocystis_turfacea_Chlorella_virus	5.0e-09	26.6
WP_004190988.1\|352531_353611_+	type VI secretion system protein TssA	NA	NA	NA	NA
WP_004190671.1\|353673_354252_+	type VI secretion system contractile sheath small subunit	NA	NA	NA	NA
WP_004190849.1\|354244_355753_+	type VI secretion system contractile sheath large subunit	NA	NA	NA	NA
WP_004190698.1\|355812_356304_+	type VI secretion system tube protein Hcp	NA	NA	NA	NA
WP_004196148.1\|356322_356883_+\|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA
WP_004190509.1\|356887_358759_+\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_004190820.1\|358755_360234_+\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_004190714.1\|360212_362867_+	type VI secretion system ATPase TssH	K4FB40	Cronobacter_phage	2.3e-78	30.8
WP_004203275.1\|362863_365068_+	type VI secretion system tip protein VgrG	A0A077K8Q4	Ralstonia_phage	9.6e-46	29.9
WP_004196151.1\|365142_365796_+	hypothetical protein	NA	NA	NA	NA
WP_011204338.1\|365755_366784_+	RHS repeat protein	NA	NA	NA	NA
WP_038802950.1\|366811_367932_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5
WP_004204352.1\|368227_368500_+	hypothetical protein	NA	NA	NA	NA
WP_011205668.1\|368496_370188_+	ShlB/FhaC/HecB family hemolysin secretion/activation protein	A0A0R6PI85	Moraxella_phage	1.9e-17	22.5
WP_004187717.1\|370288_373006_+	filamentous hemagglutinin N-terminal domain-containing protein	NA	NA	NA	NA
WP_004187807.1\|373252_375970_-	aconitate hydratase AcnA	NA	NA	NA	NA
WP_004188028.1\|376017_377469_-	bifunctional 2-methylcitrate dehydratase/aconitate hydratase	NA	NA	NA	NA
WP_004188791.1\|377545_378055_-	hypothetical protein	NA	NA	NA	NA
WP_004188261.1\|378211_379231_-	lyase	NA	NA	NA	NA
WP_004187735.1\|379428_380412_-	malate dehydrogenase	NA	NA	NA	NA
WP_004188685.1\|380710_381511_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_004536542.1\|381710_382127_+	succinate dehydrogenase, cytochrome b556 subunit	NA	NA	NA	NA
WP_004187439.1\|382131_382500_+	succinate dehydrogenase, hydrophobic membrane anchor protein	NA	NA	NA	NA
WP_004188402.1\|382504_384280_+	succinate dehydrogenase flavoprotein subunit	NA	NA	NA	NA
WP_004187935.1\|384301_385003_+	succinate dehydrogenase iron-sulfur subunit	NA	NA	NA	NA
WP_004188825.1\|385004_385277_+	succinate dehydrogenase assembly factor 2	NA	NA	NA	NA
WP_004188362.1\|385329_386631_+	citrate (Si)-synthase	NA	NA	NA	NA
WP_004187842.1\|386727_387702_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_004200651.1\|387777_387921_+	hypothetical protein	NA	NA	NA	NA
WP_038802950.1\|387931_389052_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5

DBSCAN-SWA_2

1132564 : 1191019

Leptospira_phage(33.33%)

integrase,transposase,protease

attL 1171608:1171627|attR 1196919:1196938

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004199327.1\|1132564_1133437_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_004199325.1\|1133648_1134353_-	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_004202608.1\|1134534_1135563_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_004199295.1\|1136235_1136394_+	lipoprotein	NA	NA	NA	NA
WP_004199294.1\|1136409_1136931_+	sigma-70 family RNA polymerase sigma factor	A0A076YQ50	Rhizobium_phage	5.1e-06	27.1
WP_004266248.1\|1136927_1137752_+	anti-sigma factor	NA	NA	NA	NA
WP_004202605.1\|1137820_1138807_+	YceI family protein	NA	NA	NA	NA
WP_004198481.1\|1138846_1139206_+	hypothetical protein	NA	NA	NA	NA
WP_004198480.1\|1139202_1139430_+	hypothetical protein	NA	NA	NA	NA
WP_080516843.1\|1139426_1139645_+	hypothetical protein	NA	NA	NA	NA
WP_004198478.1\|1139703_1140213_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_011204513.1\|1140267_1141212_+	iron dicitrate transporter FecR	NA	NA	NA	NA
WP_111947103.1\|1141530_1143984_+	TonB-dependent receptor	NA	NA	NA	NA
WP_004202602.1\|1144195_1145176_-	ABC transporter permease	NA	NA	NA	NA
WP_004206342.1\|1145168_1145900_-	hypothetical protein	NA	NA	NA	NA
WP_004202600.1\|1145896_1147714_-	sugar ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	9.2e-10	25.2
WP_004551656.1\|1147710_1148760_-	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_011832007.1\|1148848_1149184_-	hypothetical protein	NA	NA	NA	NA
WP_011205512.1\|1149380_1150121_+	isoprenylcysteine carboxylmethyltransferase family protein	NA	NA	NA	NA
WP_009968316.1\|1150443_1150695_-	hypothetical protein	NA	NA	NA	NA
WP_004202590.1\|1150857_1152117_-	monooxygenase	NA	NA	NA	NA
WP_004202588.1\|1152336_1153806_-	MFS transporter	NA	NA	NA	NA
WP_011204511.1\|1153848_1154163_-	hypothetical protein	NA	NA	NA	NA
WP_081335194.1\|1154202_1154853_-	hypothetical protein	NA	NA	NA	NA
WP_038802950.1\|1154894_1156014_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5
WP_004539130.1\|1156210_1156411_-	hypothetical protein	NA	NA	NA	NA
WP_004197866.1\|1156403_1156676_+	DUF4148 domain-containing protein	NA	NA	NA	NA
WP_004184766.1\|1156788_1158183_-	heavy metal sensor histidine kinase IrlS	W8CYF6	Bacillus_phage	1.2e-20	28.9
WP_004197868.1\|1158179_1158869_-	heavy metal response regulator transcription factor IrlR	W8CYM9	Bacillus_phage	1.7e-36	36.8
WP_004202583.1\|1158875_1162109_-	CusA/CzcA family heavy metal efflux RND transporter	NA	NA	NA	NA
WP_004197872.1\|1162154_1163624_-	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_133307164.1\|1163634_1164993_-	TolC family protein	NA	NA	NA	NA
WP_004197874.1\|1165053_1165239_-	hypothetical protein	NA	NA	NA	NA
WP_004197875.1\|1165255_1165540_-	hypothetical protein	NA	NA	NA	NA
WP_004524134.1\|1165937_1166078_-	bacteriophage protein	NA	NA	NA	NA
WP_004205924.1\|1166547_1166778_+	hypothetical protein	NA	NA	NA	NA
WP_004197879.1\|1166765_1167254_-	membrane protein	NA	NA	NA	NA
WP_004197880.1\|1167580_1168066_+	YbaK/EbsC family protein	NA	NA	NA	NA
WP_004184790.1\|1168333_1169689_+	amino acid permease	NA	NA	NA	NA
WP_004197883.1\|1169988_1170597_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_004199606.1\|1170735_1172736_-\|protease	ATP-dependent zinc metalloprotease FtsH	E5EQU5	Bathycoccus_sp._RCC1105_virus	1.1e-104	46.2
1171608:1171627	attL	NA	NA	NA	NA
WP_011204479.1\|1173351_1173984_+	hypothetical protein	NA	NA	NA	NA
WP_011204480.1\|1174108_1175875_+	amidohydrolase family protein	NA	NA	NA	NA
WP_004199157.1\|1176005_1176677_-	transcriptional regulator	NA	NA	NA	NA
WP_004184876.1\|1176827_1177925_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_004199160.1\|1177921_1181023_+	MMPL family transporter	S5VTK5	Leptospira_phage	3.6e-46	22.0
WP_004266238.1\|1181157_1182696_+	efflux transporter outer membrane subunit	NA	NA	NA	NA
WP_073699266.1\|1182692_1183007_+	hypothetical protein	NA	NA	NA	NA
WP_004539149.1\|1183025_1183670_+	GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	7.2e-34	44.6
WP_004197695.1\|1183666_1185364_+	WD40 repeat domain-containing protein	NA	NA	NA	NA
WP_004197696.1\|1185360_1186041_+	1,6-didemethyltoxoflavin N1-methyltransferase	NA	NA	NA	NA
WP_004197697.1\|1186114_1187812_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_011204482.1\|1187902_1188358_-	hypothetical protein	NA	NA	NA	NA
WP_004199610.1\|1188719_1189877_-	DUF746 domain-containing protein	NA	NA	NA	NA
WP_038802950.1\|1189898_1191019_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5
1196919:1196938	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1333457 : 1365297

Leptospira_phage(42.86%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_038802950.1\|1333457_1334577_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5
WP_038802950.1\|1335446_1336567_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5
WP_004199588.1\|1336712_1337123_-	heme-binding protein	NA	NA	NA	NA
WP_004198129.1\|1337182_1338583_-	4Fe-4S binding protein	NA	NA	NA	NA
WP_004198128.1\|1338579_1339422_-	iron transporter OFeT family	NA	NA	NA	NA
WP_004198127.1\|1339481_1339811_-	cupredoxin domain-containing protein	NA	NA	NA	NA
WP_004266710.1\|1339870_1340422_-	membrane protein	NA	NA	NA	NA
WP_004199587.1\|1340645_1342736_-	excinuclease ABC subunit UvrB	NA	NA	NA	NA
WP_004198124.1\|1343023_1344223_+	aspartate/tyrosine/aromatic aminotransferase	NA	NA	NA	NA
WP_069605617.1\|1344365_1345829_+\|transposase	IS1182-like element ISBma2 family transposase	A0A1X9I5T2	Streptococcus_phage	6.8e-80	38.6
WP_011204445.1\|1345873_1346008_-	hypothetical protein	NA	NA	NA	NA
WP_004204588.1\|1346033_1346822_-	3-hydroxybutyrate dehydrogenase	NA	NA	NA	NA
WP_004198121.1\|1347009_1347981_+	NADP-dependent aryl-alcohol dehydrogenase	NA	NA	NA	NA
WP_004198120.1\|1348129_1348975_+	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	NA	NA	NA	NA
WP_081335195.1\|1348987_1349314_-	hypothetical protein	NA	NA	NA	NA
WP_004191998.1\|1349475_1350939_+\|transposase	IS1182-like element ISBma2 family transposase	A0A1X9I5T2	Streptococcus_phage	8.8e-80	38.6
WP_004198117.1\|1351063_1351210_-	DUF3563 domain-containing protein	NA	NA	NA	NA
WP_038802950.1\|1351359_1352480_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	3.6e-49	39.5
WP_009941318.1\|1355938_1356088_-	hypothetical protein	NA	NA	NA	NA
WP_073699529.1\|1358096_1358213_-	phenylacetate-CoA oxygenase	NA	NA	NA	NA
WP_011204046.1\|1358291_1358426_+	hypothetical protein	NA	NA	NA	NA
WP_004194622.1\|1358652_1359204_-	HD domain-containing protein	A0A2K9L141	Tupanvirus	2.3e-20	34.1
WP_004194628.1\|1359208_1360663_-	phosphonoacetaldehyde dehydrogenase	NA	NA	NA	NA
WP_004199121.1\|1360659_1361931_-	phosphonoacetate hydrolase	NA	NA	NA	NA
WP_004194685.1\|1361974_1362835_-	2-aminoethylphosphonate ABC transport system, membrane component PhnV	NA	NA	NA	NA
WP_069605619.1\|1362824_1363772_-	2-aminoethylphosphonate ABC transporter permease subunit	NA	NA	NA	NA
WP_004191998.1\|1363833_1365297_-\|transposase	IS1182-like element ISBma2 family transposase	A0A1X9I5T2	Streptococcus_phage	8.8e-80	38.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP017175

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP017176

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection