CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP016444	Burkholderia stabilis strain ATCC BAA-67 chromosome 3	1 crisprs	WYL	0	1
NZ_CP016443	Burkholderia stabilis strain ATCC BAA-67 chromosome 2	0 crisprs	csa3,cas3,DinG,cas14j,WYL,PD-DExK	0	0
NZ_CP016442	Burkholderia stabilis strain ATCC BAA-67 chromosome 1, complete sequence	2 crisprs	DEDDh,DinG,csa3,cas3,WYL,PD-DExK	2	6

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP016444_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016444_1

935973-936064

Orphan

Consensus_repeat	Method
GGGAGAAATACCTGAATCGCTCCCCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016444_1

>merge|NZ_CP016444|1|935973-936064|CRISPRCasFinder
GGGAGAAATACCTGAATCGCTCCCCGAGTTCATACGTGTATGCGTGCCGCCTGGCGACGCACGAGGGGAGAAATACCTGAATCGTTCCCCGA

>NZ_CP016444|1|1|935973-936064|CRISPRCasFinder
GGGAGAAATACCTGAATCGCTCCCCGA	GTTCATACGTGTATGCGTGCCGCCTGGCGACGCACGAG
GGGAGAAATACCTGAATCGTTCCCCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016444.1\|WP_069751171.1\|934630_935911_-\|methyltransferase	unknown	unknown	gnl\|CDD\|223504
NZ_CP016444.1\|WP_069751501.1\|929813_930719_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377694
NZ_CP016444.1\|WP_069751170.1\|933275_934559_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP016444.1\|WP_069751180.1\|950666_951716_-\|dipeptide-epimerase	unknown	unknown	gnl\|CDD\|239435
NZ_CP016444.1\|WP_069751165.1\|925960_927226_-\|sulfite-dehydrogenase	unknown	unknown	gnl\|CDD\|275348
NZ_CP016444.1\|WP_069751176.1\|942070_943714_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|224594
NZ_CP016444.1\|WP_069751169.1\|932163_933279_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187575
NZ_CP016444.1\|WP_069751177.1\|946375_947368_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|236531
NZ_CP016444.1\|WP_069751163.1\|924167_925355_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|238527
NZ_CP016444.1\|WP_069751164.1\|925440_925968_-\|cytochrome-c	unknown	unknown	gnl\|CDD\|365823
NZ_CP016444.1\|WP_069751168.1\|930946_931861_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223999
NZ_CP016444.1\|WP_069751166.1\|927349_928534_-\|porin	unknown	unknown	gnl\|CDD\|238208
NZ_CP016444.1\|WP_069751181.1\|951708_953070_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340886
NZ_CP016444.1\|WP_083282140.1\|940234_941653_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223928
NZ_CP016444.1\|WP_069751502.1\|943733_945866_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP016444.1\|WP_069751172.1\|936067_938464_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226418
NZ_CP016444.1\|WP_069751179.1\|948995_950657_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP016444.1\|WP_069751173.1\|938657_939617_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225375
NZ_CP016444.1\|WP_069751167.1\|929018_929363_+\|DUF3088-domain-containing-protein	unknown	unknown	gnl\|CDD\|371452
NZ_CP016444.1\|WP_069751178.1\|947494_948961_+\|M81-family-metallopeptidase	unknown	unknown	gnl\|CDD\|227763

Protein	Function_ID	Function_description	E-value
NZ_CP016444.1\|WP_069751171.1\|934630_935911_-\|methyltransferase	gnl\|CDD\|223504	COG0427, ACH1, Acetyl-CoA hydrolase [Energy production and conversion].	3.80469e-49
NZ_CP016444.1\|WP_069751501.1\|929813_930719_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|377694	pfam06719, AraC_N, AraC-type transcriptional regulator N-terminus. This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.	4.70543e-51
NZ_CP016444.1\|WP_069751170.1\|933275_934559_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	3.95837e-145
NZ_CP016444.1\|WP_069751180.1\|950666_951716_-\|dipeptide-epimerase	gnl\|CDD\|239435	cd03319, L-Ala-DL-Glu_epimerase, L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of the murein peptide of peptidoglycan, of which L-Ala-D-Glu is a component. L-Ala-D/L-Glu epimerase is a member of the enolase-superfamily, which is characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	2.23992e-111
NZ_CP016444.1\|WP_069751165.1\|925960_927226_-\|sulfite-dehydrogenase	gnl\|CDD\|275348	TIGR04555, probable_sulfite_oxidase_molybdopterin_subunit, sulfite dehydrogenase. Members of this family are the sulfite dehydrogenase SoxC. All members have a twin-arginine translocation (TAT) signal for secretion of proteins with bound cofactor across the plasma membrane.	0
NZ_CP016444.1\|WP_069751176.1\|942070_943714_-\|serine-hydrolase	gnl\|CDD\|224594	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms].	1.22216e-47
NZ_CP016444.1\|WP_069751169.1\|932163_933279_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187575	cd05265, SDR_a1, atypical (a) SDRs, subgroup 1. Atypical SDRs in this subgroup are poorly defined and have been identified putatively as isoflavones reductase, sugar dehydratase, mRNA binding protein etc. Atypical SDRs are distinct from classical SDRs. Members of this subgroup retain the canonical active site triad (though not the upstream Asn found in most SDRs) but have an unusual putative glycine-rich NAD(P)-binding motif, GGXXXXG, in the usual location. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.24247e-34
NZ_CP016444.1\|WP_069751177.1\|946375_947368_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|236531	PRK09467, envZ, osmolarity sensor protein; Provisional.	2.56688e-59
NZ_CP016444.1\|WP_069751163.1\|924167_925355_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|238527	cd01094, Alkanesulfonate_monoxygenase, Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin mononucleotide (FMNH2), which is provided by the NADPH-dependent FMN oxidoreductase (SsuE).	3.87836e-74
NZ_CP016444.1\|WP_069751164.1\|925440_925968_-\|cytochrome-c	gnl\|CDD\|365823	pfam00034, Cytochrom_C, Cytochrome c. The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, pfam06181, has now been merged into this family.	8.64311e-10
NZ_CP016444.1\|WP_069751168.1\|930946_931861_+\|alpha/beta-hydrolase	gnl\|CDD\|223999	COG1073, COG1073, Hydrolases of the alpha/beta superfamily [General function prediction only].	7.45116e-30
NZ_CP016444.1\|WP_069751166.1\|927349_928534_-\|porin	gnl\|CDD\|238208	cd00342, gram_neg_porins, Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers are stabilized by hytrophillic clamping of Loop L2. Loop 3 bends into the pore, creating an elliptical constriction of about 7 x 11A, large enough to allow passage of a glucose molecule without steric hindrance. Removal of the C-terminal residue (usuallly F) destabilizes the trimer and removal of the 16th beta-sheet abolishes trimerization. Unlike typical membrane proteins, porins lack long hydrophobic stretches. Short turns are found at the smooth, periplasmic end, longer irregular loops are found at the rough, extracellular end. C-terminal residue forms salt bridge with N-terminus.	1.9056e-89
NZ_CP016444.1\|WP_069751181.1\|951708_953070_-\|MFS-transporter	gnl\|CDD\|340886	cd17328, MFS_spinster_like, Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters. The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.83067e-41
NZ_CP016444.1\|WP_083282140.1\|940234_941653_-\|hypothetical-protein	gnl\|CDD\|223928	COG0859, RfaF, ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane].	5.38294e-08
NZ_CP016444.1\|WP_069751502.1\|943733_945866_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	6.77611e-57
NZ_CP016444.1\|WP_069751172.1\|936067_938464_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	1.76642e-51
NZ_CP016444.1\|WP_069751179.1\|948995_950657_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.50773e-44
NZ_CP016444.1\|WP_069751173.1\|938657_939617_+\|hypothetical-protein	gnl\|CDD\|225375	COG2819, COG2819, Predicted hydrolase of the alpha/beta superfamily [General function prediction only].	1.43404e-13
NZ_CP016444.1\|WP_069751167.1\|929018_929363_+\|DUF3088-domain-containing-protein	gnl\|CDD\|371452	pfam11287, DUF3088, Protein of unknown function (DUF3088). This family of proteins with unknown function appears to be restricted to Proteobacteria.	5.62591e-52
NZ_CP016444.1\|WP_069751178.1\|947494_948961_+\|M81-family-metallopeptidase	gnl\|CDD\|227763	COG5476, COG5476, Uncharacterized conserved protein [Function unknown].	4.11034e-170

>NZ_CP016444.1|WP_069751171.1|934630_935911_-|methyltransferase
MTAPTHASSEFSLADYLRPNDTVLVGQAAAEPHELVAQLINASQQIANLTVVCGYALSDDWKRVTRGKPRVATYSAHGPLRSLARSGEIDILPNHYSHFERLVTTGAFQPDVILLQLPPADPDGYHSFGTSVDYVAKAAQAAPAAAPAGTADRPGPVIIAEINENMPSTRTKWRLHRSQITAWFATDRPLEGTPARALSDIDHAIARNVASVVPDGASIQLGIGALATAIGRALREHRELRVRSGLVGDWLLDLDASGALASGEDACVAGMALGSAELYEFVARHDRIRFVPITDLTASEAVASCNPFIAVNSALEVDLLGQVNSEVVGGQYIGALGSQVDTFRATRIASSGLAIVAMPARGPKGGPQIVSTLSGPVTSLQSDIDMVITEYGVADLQGTTVAERAERLIGIAAPEHRDALREARRS
>NZ_CP016444.1|WP_069751170.1|933275_934559_-|CoA-transferase
MPNPADHIPFTIGGAESGALPLSGVRVVDLTQVGAGPYCTSLLGDLGADVIKVEPLEGDTFRYVDDAFGEGESAYFYGVNRSKRSIALNLKSERGFEVLTRLVKEADVFAVAFRPDAVQRMGIDYESLRKINDRLIYCSITAFGETGPRAHLPGMDILAQAMSGIMGVTGEIGGGPVKVGVPIADFVASYLLGFGVCAALRLRDRTGQGDKVTVNLLDGMIASFANYLTVYDKTRVPFRRQGGGHPQLVPYQPFLGADQKHFILACMNDKFWQKMLPLLDRYGDFHDPRFATNTGRVTHRSELCGRLEAIFATQPADYWLAALEAAGVPCGPIHALEDAIEDPQAIANESLTTLNHPIHGEYRVPNNPIRFAAAPTGPRGYAPALGEHTAEILREAGFDDAEIASLTSAGIAREAFTQQQNHTETTS
>NZ_CP016444.1|WP_069751169.1|932163_933279_-|NAD-dependent-epimerase/dehydratase-family-protein
MKALVIGGTGPTGPFIVEGLRQRGYETTILHTGRHEIDLPDDVPHIHTDPNFLEGLTEALKGHRYDLVVATYGRLRLFVDALAGVSERLITVGGAAYGDNLARPSAEDGPRKTGHKLSEKIVETEQILMDAHLAGRYNITHLRYPCLFGPRQLAPREWSIIRRLRDGRTHVPVINGGLTLETKAYVENAANAILLSVDQPETSSGQIYNVADAYTPSDATLVRTIAKVMGVEVELANFTPEMGRPAYFWGANRDLNFTRTGLPPTTHHLLIDSGKIRSELGYTDLISFEEGIKRTVEHYLEHPLGIEAEQQIGDPFDYAAEDTFIALLDEMNARAAALPFAGVRYQHPYAHPKAPGEADAGAGMAVAGSQR
>NZ_CP016444.1|WP_069751168.1|930946_931861_+|alpha/beta-hydrolase
MKTNVSFTSNGLKIAGHLYLPDGYKEGEKLPAIVTSHPFGGVKEQTAGLYAQKLADKGFVTLAFDASYQGESEGEPRYLEDPFTRAEDIKSAVTFLANRAEVDAERIGALGICASGGYVPYTAQTERRIKAVAAVSGADMGALFREGLGGGGSKEALQAMLEQSGKARTAEANGEPAHLEHIVPNTPGEITKDTPTLYAEGTDYYRTPRAQHPNSPNWFVFRSVDRIAAYSSYDRVDLISPHPLLMIAGTRADTRYFSELAIEKAQEPKELFLIEGASHIDLYDKEEYVGPAVEKLGSFFKQYL
>NZ_CP016444.1|WP_069751501.1|929813_930719_-|AraC-family-transcriptional-regulator
MLDLLNQLAPNEGATQSRLDSVKFVRANRSIARTPIMYEPSIVFLCQGRKRAFVGQHVYTYDANQYLVLSVPLPLECETEASEDAPMFAVCVRVDADVLVDLLELLDSRCGRTDAAPTGIFTTALSDEMSDAVMRLLKSLCSTVEADVLGPSIVREICFRILTGEQGDVLRAALMRRNDFGQIAQALRRIHRDFSSDLSVGMLADEAHMSVASFHAKFKAVTATSPLQYLKITRLQKARLLMLHSGVGAAAASSKVGYESPSQFSRDFKRLFGRTPTKEVEHARSNAALMPLESTSVYVTS
>NZ_CP016444.1|WP_069751167.1|929018_929363_+|DUF3088-domain-containing-protein
MSRDVLFLLEPGFADPKHPGQRFVCPHGLSIEGLLASAPDLAGRIDVKRVGFERPRPDVIDALDDAHQGLPVLVLGAGQLAPDDAQTLGDVRFVTDARRILELLAERHGFPALH
>NZ_CP016444.1|WP_069751166.1|927349_928534_-|porin
MIKKSVVLGLVSIGSVNAYAQSSVTLYGVVDAGIAYTNNQGGASNIQQTSGKLSGSRWGLKGAEDLGGGLQAVFTLEGGFRPSDGGLGQGGRLFGRSAYVGFAKQGLGTLTFGRQYEPITDLVAQYSGSGFWSPATHVGDNDNMNQSFRLNNAVKFRSDTIAGFTADLLYAFSNQANGGAGTGFSNNNAWGVSANYVNGPLSVGGGYVRLNHPNATSNTTGAVGGATSTTGNDYSGAFFYGLNGGVLKQQIGAVGANYALGRATLGFAWSHTQLDYVDGSSRKFNNYDVNARYQITPAATLIGVYTFTDGRASGLPGTGGQTLKPRWHQFTLGFDYALSKRTDLYLSGIYQLAAGDPSSATAGGYRAVASIANIGSASSTNRQVAVVSGLRVKF
>NZ_CP016444.1|WP_069751165.1|925960_927226_-|sulfite-dehydrogenase
MTDSRSPSRAPRTGRRAALRQLAGGWAAAMLPAGGALASQPLASLDVPPWTRTPGAPLLSPPYGVPGPHESNVIRRSARSPALPGSGSSMTPLADLFGDITPNGLVYERHHAGVPEIDAQRHRVVVHGLVREPRVFTIDDLLRFPSESRIHFLECSGNTGSEWNGPSGLPVQFTHGLLSCCEWTGVRLSTLLDETGVDPDARWLLAEGADGAAMTRSLPLDRILERALVVYAQNGERLRPENGYPVRLIVPGFEGNTNIKWLRRLKLVRAPEMTREETSKYTNLLPDGCARQFVFEMDAKSVITRPSAGHRLAVHGYHPISGYAWSGRGRIRAVDVSTDGGRTWRPARITGDVRDRALTRFEADWVWSGEPAELQSRATDETGYVQPTRDALVAARGLNSQYHYNGIQNWRVGADGEVRNA
>NZ_CP016444.1|WP_069751164.1|925440_925968_-|cytochrome-c
MRSLLATSALACCLIAMPAFGAGFGLGQPIDRAALSAWDIDVAPDGSGLPPGAGRVARGGHVFADKCAMCHGAHGEGGVGDPLVGGIGSLAGTKPKKTVGSYWPYATTLFDYIRRAMPYNAPQSLSADDVYAVTAYVLHLNGIVPDDARLDARTLPRVQMPNRAGFVPDPRPGKL
>NZ_CP016444.1|WP_069751163.1|924167_925355_-|LLM-class-flavin-dependent-oxidoreductase
MSDTSLAASVAPSPFVDVRSPADFPDSPVSRVLAQPLMLGLFLPIQAGGWSASTLPRSTDWTFDYNAELVARAEALGFDLVFALSQWLPKGGYGGVFDGQALDSFMTLAALTARTERIMLVATNHVLYGPWHPLHFAKFTATLDHISRGRWGINVVTGHRAIEHEMFGWNRIEHDRRYEMAAEFLDAVQQLWAQPDNFSYAPALSSWRLGGAFVTPKPSYGRPLLINATGSDAGIDFAARYSDIVFVTSPAGPDAERAIDALPAHTARVKAAAAARGRTIRTLLNPLVICRETAAEARAYRDAIVAHADEGSFHRFDSDAHAWRGGFEQRAQAAARAIGGNISITGSPGEVADTIVRLHRAGIDGIQLSFYDFKPDLDFFGERVLPLLRDAGLRR
>NZ_CP016444.1|WP_069751172.1|936067_938464_-|LuxR-family-transcriptional-regulator
MRSPDQGNLPADVSSFIGRTAELEKVRTLLVSTRLLTLIGSGGVGKTRLARQIAAEHRHVFRDGVWFVDLTDITDGDLLPSVIGSRLGLFHTPTETAGDLAEHLPGEHMLLVVDNCEHLIEPVALLLHDLLAAAPELRVLTTSRQVLGVPGERVLPIPPLAAPPADETMANRDDPAPAGAGSPAIPDSVLLFADRAAAALPGFAIDHSNRDLLYRICHRLEGIPLAIELAAARLRAFSLEMILERLDGSLRALASTLRTTPERHRTLESTVAWSYALCSAPEQVLWARLSVFADGFTVDAAEDVCSGGPIVREQIFDLLTGLVDKSILTREGGPGGGTSRLKMLGLLREFGIQRLREAGEEAQFRQHHLDYFRTLAGRGETAYFSPREMEWARRVREEHANLRAAAEYCSAELHDYASVMAIVAPLQLYRVGASYVVEEHRWLAAALEHDRAPSETRARALVACSYAASLMGNGDEAEQRAREAADLADALELPGVAADAACGIARASFHGGDRARTLRLSEAAVALCTASGNLAGACDALYRAAVTALGMHDERAAEFARASLALAQEHGSPYRIASGLWIDGFCLWRTGDQQLASARLREALPLYEARGFVEGIAMCCEGLALTAAALGQAEHAATLKGAAHAAWRRAAAPFPQAVVRSLGTDTVDAQIRTALGEARYRAAFDHGAAFSVADAARYAIGDAPELAAEPAPGLIPTEALAPRPADAAKALIAEGLTRREAEVAALIAEGLSNRQIAERLVIAQRTAEGHVERILAKLGFRSRAKVAAWVAKRQRTHE
>NZ_CP016444.1|WP_069751173.1|938657_939617_+|hypothetical-protein
MIVPTLESWQPELREVIATTRSFTLRSEIVGGAFAVWVTVPPGYGAGDAALPVLYVADGNTQLAITAPTGSLMMMHETSPIRPFIQVTIGYLGDDARNFLKVRNRDLVPPDEPFPHQMAAHLRPRVERGTLSEEKYAAILADLSHSAGDRFLAFIERELHPRIAERWRVDADDVGLFGYSYGGLFAMYAFATASPLFTVIGASSPGILSAESEVFRRYDRRLAEGDRTLPPRLHLTINDSETSSEFALYRDLSQHYLALVDRIRRTPLPGLRATAEVIRGETHGTGIVDAYRSFVRSCYAVRGHDPRTEISWPVEHDTN
>NZ_CP016444.1|WP_083282140.1|940234_941653_-|hypothetical-protein
MTPDNPVAEVQRLVQCGAIDEARRLLENLSDTDGASAQYFHACAQFHYLLGEFEEAVDRCLTVTQRAPGYANHRLIFFHACAHLGRIDLIDAQFDALVQGLDEWDRQRVLLEALYISGRDDEVIARSASYQAAHEAGTIPHATAIQLRKSRSTSLMRAHGISAGIGEYASSFTSRPAVSEVYGVNDPGYWCGDTPLPRVLRYVRGGGFGDWVQFLRYRALLAQVGTELVCHEPWPCPDVNPAWLNDYRDVGAGDLLKPLVGNAPLDEMWATPFSLFTAMFPLAGYLPAQRAMVESAPSPELAEQVERIRRAARGRPCCALFWSSNESAHGDFAWKSLRLQQIRPLLENQDIHWIVFQRGLEMQRWLADDLSQTATNIDSTTDLHSLAVLLSAAADLVISIDSGPLHLAASLDLPTILLSPLHGDWRYERLPTSTPWYPGVRIVRQPAIGAWDATVADAQWVLDGWCRTGRFS
>NZ_CP016444.1|WP_069751176.1|942070_943714_-|serine-hydrolase
MKQESHDIAQQLDTLFERFNKCDEPGLVVAVAHRGEILYRRGFGMASLEHGVANSPATRLRIGSTSKHFTCLAALLLAEDGKLDIDAGIRTYLPELPLLAGDPSLRQLMTHTGGYRCYLDLTLLAQGVATLPRGGALAAEVRQRDVNFPPGERMIYCNGGYHLLSLAIERVSGIPFETFLKERIFDVMGMVDTESVADDMRIRPRMATQHVPDGKGGFMRGLFPTWEVLGEGGIVSTVDDMLLWLAHLRGPKRLGSEASWRQMLTKPHYSSGAEGVYALGLMRTPHRDVEVLHHAGGVFGGACQMLTVAKQALDVIILTNGAAANPVELATQVVDIVLGDAILGAKPAAPLQTAGHETLLGKYHSRASGTLCVIDDHDGQVNAIFHNVKQMPQPLIETAAGLRVDDGAGGALLIKPRAPTAEARVTALELVDCGHAETLERLPDHAPSFSDASAGLAGTYHGHDAAARATIAVTNGELTMTMDGVAGSVGYRLEPVADDIFTFAPVGQLAVMHGVLTVERSGNEVTRFRIDTARTRNLNFEREVCGS
>NZ_CP016444.1|WP_069751502.1|943733_945866_-|TonB-dependent-receptor
MSKAQGKGGATLNTVVVTAARRREPAREVPMQVNVLSADELQKSGAKTMSDYLSAEPGVDLNASGGSGSGQVSIRGVTTGIQTGPTVGMYIDDVAFGGSTLFSQSATFALDMSLLDLNHVEILRGPQGTLYGAGAMGGLLKYVTNEPDSGQFSGQVGTGVSGTAHGGVSGTANAALNIPLKTDVAALRVSVFGQHDGGYVDAVGPEAGSHIDRGDTYGARASLLLTPTRDLTVRLTAVSQNINRNDPNYVEYGTNGQSVWGDLTTQQFAAQPFHQNIQLYSAGVEYELGWARLNSITSYQRINSSAPQDLTGVYGPLFAAQGLNLGSVVAKDVATTNKFTQELRLTSPGNQRLEWLAGLFYTHERSNLNEGFLTTLPDGSPGPNLSEIQAPSTYNEYAAYGDLTYHLTPRLSLTGGVRIAHNTQTYEQTTSGTLAGPTQTVSAPSSDTSKTYMFTARYALTPNSNAYVRIASGYRPGGPNALLIDPLTGIRASGSPTFAPDTLWSYEAGYKADLLDKRLSLETSVYDIEWKNIQQLGTVDGVNQVINAGNARIKGLEFSGTFRPGPHWNFSANLSLIDASLTTGNASAGTTAGQPLPNSAKFSATFSGTYLFTAQGYPSYAGITQRFVGRRHSGFDASSGRPDYPLPGYAITDLQAGVDFRKFSLAFYVRNLFDRRALIAAGTSLMPLGGPALVSVIQPRTIGAALTVPF
>NZ_CP016444.1|WP_069751177.1|946375_947368_+|two-component-sensor-histidine-kinase
MQKPRFDSAFYRLFFVMISIILVMQISAGLLLFKLYSTAPFKPPPGMSASLQWCAAVMIQVMPALISSWIGARMLAAPFRSLAVGAAELSRNIDAPPIEEIGPVEARQAASVFNTMQASLRRQMSERNRFLAAVSHDLRTPLTRMTLRLRSAQDVELSERLRADIDEMTQLLEATLSFLRNEEVVEAFSPVDINALVDAIAEDAAENGQKVTISGEVPPISAQPLGLKRCLTNLVANAIRYGEDAHIRLFDAPSCVRIQIADHGPGIPESQLERALEPFYRVESSRNKNTGGTGLGLAIANDVVKRHGGELVLRNGTEGGLVAQVTLPRR
>NZ_CP016444.1|WP_069751178.1|947494_948961_+|M81-family-metallopeptidase
MKIYTAQLSTETNTFAPCPTGWGGFEESTIFRGDASLREPEGIGHVLAEVRRLAEGDGHEIVEGLCAEAQPSGRTIRAVYESLRDEILDGVKAALPLDAVILLLHGAMVAEGYDDCEGDLLAGVRAIVGPGVPISVTLDPHCHFTQRMKASADVLIAYKEYPHIDAIDRAREAYRLALDMAAGRIRPTIGVFDCRMVGAWHTTSEPMAGFVRRMQSLEGHDGVLSVSLGHGFPWGDVPEAGAKLWVVTDNDLAKAEALAAQLAREFWELRDATRPAWLDIDSGLDRALAVEGGPVVLADVADNPGGGAPCDSTFILRRVVERRIANVAIGCFWDLGAIQICKDAGVGATLNLRIGGKCSVYSGDPIDLRVTVRSVVERHTQSIMGLEQPLGRAVWVEADNGLDLALISVRTQVLGVDAFTGLGIDFAGKKLVIVKSTQHFQTDFAPRAEAIFHIAAPGALTMDFANLDYRHRDLDYWPRVSNPFASAM
>NZ_CP016444.1|WP_069751179.1|948995_950657_-|serine-hydrolase
MTSDSSATTAQLDALFAPYRRADAPGLIAGIVHRGQLLYRRGFGMASLEHGIANTPATRMRIGSVSKHFTCLAVLLLCERGAVDADAPIGAYLPELPPAAGRPTLRQLMSHRGGQRCALDLALLTQGLAISPHGALLASQQRQRDENFPPGERMMYSNGGYHLLSLAVERASGMSFDAFLTTHIFNPMRMRDTACVPDDMTIGRGIATMHVPDGKGGFRRGIFPSWELLGEGSIVSTVDDMLRWTAHLRCGNKIVGSDDTWMQMLALPVFSSGERSQYALGLKQSLYRGVELIHHAGGVVGGTCQMLLSAAHGLDVVLLGNGALDAPLELSKRIVDIVLAGELDGDGPPVAARAASHVARLGSYRSSSTGAVYALEDHEGALVLTGPLCPAPSMPLYDSAHDLNDVEIEAGGDGPLALRWGSSCTPDDLSSLRIVHCGHVETFARLGEAPAMTPSLVAAMSGTFASHDANARAIIRLDDEALVLRMHGAVGRCDYRLTPLADDVFGLVPVDPMDVMTGIVTLTRDATSANISGFLVDTQRTRNLAFTRVQADA
>NZ_CP016444.1|WP_069751180.1|950666_951716_-|dipeptide-epimerase
MRNSLLPPYSMSPRTLSLSLRIERWPLAVPFHITGHVIDAARVVRVTVDDGHHAGNGEASGVFYRGETPESIVAQIESVRASIEAGITRAQLLDVLPHGGARNAVDAALWALESQQQAMPVWRMAGLCAPRLLLTTMTIGVDTPDAMAAAARMLPHARALKVKLDGSAADAARLAAIREVRPEVPLAVDANQGWSRAHFDAMIPVLQQLDVRMLEQPFAIGADACLEHVDCPIPLAADESFQDLGDLPAVARRYDIVNLKLDKCGGLTRAFDLATRVREAGLSVMVGCMAGTSLAVAPAFLLGQQCDHVDLDGPIFLARDRETGVAYIDGLLHCPPGSWGHAGVTASSR
>NZ_CP016444.1|WP_069751181.1|951708_953070_-|MFS-transporter
MFDSNLDLPAPEAAQSPPSDSPAGPLAWFGLAILVIVAFFAFVDRQMLILLTEPIRHDFGLTDTQIGLMQGAGIALFAGVASLPIGWIADRVDRRMVLVACVLVWSAATAICGMTTHFWQLFIATVGLGIGEAGLVPVIYGLIPDLFPARQRVLANAIFALANLLGAGAGMALGGALMHGIAAVHGALPAGLADLAPWRLAFFAVALPAPVLVVLVLLIRPGRHGDTEASATRHRPSAPLPSAPVYFRREAVMMLKFFGAIGLVNLSFGGVATWMPVVAVRTFGATPAEAGGGMGVAAMAGGIAGCVLSGLVAGRMRARFGVLAPLRVCECGALAAGGLSFLYLAVGSLTPVYALFGAQLACMVAGMVLFPTIMQNICPAHLRSRVAAIGALTSIVVQSGSPVFIGFMSDRLHAFGQGLLWSIVCVAAFGFFAACILMRAAGRGVREAIERYA

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1061323 : 1128123

Burkholderia_phage(50.0%)

transposase,tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_069751255.1\|1061323_1061833_+\|tRNA	glutamyl-tRNA amidotransferase	NA	NA	NA	NA
WP_069751256.1\|1061866_1063774_+	ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein	E5EQU5	Bathycoccus_sp._RCC1105_virus	1.0e-104	43.2
WP_069751257.1\|1064860_1065181_+	DUF1840 domain-containing protein	NA	NA	NA	NA
WP_059666580.1\|1065778_1066204_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_081085407.1\|1068012_1069935_+	chloride channel protein	NA	NA	NA	NA
WP_060170317.1\|1069918_1070173_+	hypothetical protein	NA	NA	NA	NA
WP_059710520.1\|1070243_1070747_-	peptidoglycan-associated lipoprotein Pal	NA	NA	NA	NA
WP_156815001.1\|1071182_1072340_+	MFS transporter	NA	NA	NA	NA
WP_060349225.1\|1072396_1073716_+	chloride channel protein	NA	NA	NA	NA
WP_069751259.1\|1073772_1074171_+	hypothetical protein	NA	NA	NA	NA
WP_155687434.1\|1074290_1074683_-	hypothetical protein	NA	NA	NA	NA
WP_060349226.1\|1074842_1075469_-	ubiquinol-cytochrome c reductase iron-sulfur subunit	NA	NA	NA	NA
WP_060349227.1\|1075566_1076001_-	carboxypeptidase regulatory-like domain-containing protein	NA	NA	NA	NA
WP_069751260.1\|1076052_1077021_-	hypothetical protein	A0A1B1IT49	uncultured_Mediterranean_phage	3.1e-12	31.3
WP_156815002.1\|1077168_1077312_+	hypothetical protein	NA	NA	NA	NA
WP_069751261.1\|1077488_1078748_+	sodium:proton antiporter	A0A2H4J178	uncultured_Caudovirales_phage	6.3e-42	40.6
WP_069751262.1\|1078752_1079610_-	hypothetical protein	NA	NA	NA	NA
WP_069751263.1\|1079606_1081154_-	F0F1 ATP synthase subunit alpha	NA	NA	NA	NA
WP_069751264.1\|1081131_1081884_-	hypothetical protein	NA	NA	NA	NA
WP_038442209.1\|1081893_1082142_-	F0F1 ATP synthase subunit C	NA	NA	NA	NA
WP_069751265.1\|1082150_1082837_-	F0F1 ATP synthase subunit A	NA	NA	NA	NA
WP_069751266.1\|1082833_1083118_-	hypothetical protein	NA	NA	NA	NA
WP_083282158.1\|1083121_1083466_-	AtpZ/AtpI family protein	NA	NA	NA	NA
WP_069751267.1\|1083455_1083920_-	F0F1 ATP synthase subunit epsilon	NA	NA	NA	NA
WP_069751268.1\|1083916_1085347_-	F0F1 ATP synthase subunit beta	NA	NA	NA	NA
WP_069751269.1\|1085679_1086369_+	CBS domain-containing protein	NA	NA	NA	NA
WP_069751270.1\|1086550_1087117_-	cytochrome b	NA	NA	NA	NA
WP_060349418.1\|1087160_1087535_-	cytochrome B562	NA	NA	NA	NA
WP_060349238.1\|1087701_1088364_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.7e-30	36.4
WP_060349239.1\|1088363_1089713_+	HAMP domain-containing protein	NA	NA	NA	NA
WP_069751513.1\|1089966_1090284_+	DUF4148 domain-containing protein	NA	NA	NA	NA
WP_069751514.1\|1090906_1093843_+\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	1.7e-50	22.2
WP_069751271.1\|1095958_1097176_-	MFS transporter	NA	NA	NA	NA
WP_069751272.1\|1097357_1098656_-	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_069751273.1\|1098659_1099493_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_069751515.1\|1099464_1100364_-	tetrahydrodipicolinate succinyltransferase	NA	NA	NA	NA
WP_156815003.1\|1100388_1101357_-	hypothetical protein	NA	NA	NA	NA
WP_156815004.1\|1101383_1102553_-	hypothetical protein	NA	NA	NA	NA
WP_069746659.1\|1102782_1103874_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_069751276.1\|1104026_1104791_-	hypothetical protein	NA	NA	NA	NA
WP_006412423.1\|1105195_1106188_+\|transposase	IS5-like element ISBmu2 family transposase	E5E3P6	Burkholderia_phage	5.3e-161	85.5
WP_069751277.1\|1106656_1107019_-	hypothetical protein	NA	NA	NA	NA
WP_006412423.1\|1107359_1108352_-\|transposase	IS5-like element ISBmu2 family transposase	E5E3P6	Burkholderia_phage	5.3e-161	85.5
WP_156815006.1\|1108568_1108817_+	hypothetical protein	NA	NA	NA	NA
WP_156815007.1\|1108813_1108978_+	hypothetical protein	NA	NA	NA	NA
WP_069751279.1\|1109257_1110424_+	porin	NA	NA	NA	NA
WP_069751280.1\|1111042_1112062_-	acyltransferase	A9YX16	Burkholderia_phage	7.3e-49	37.5
WP_069751282.1\|1112642_1114421_-	M61 family metallopeptidase	NA	NA	NA	NA
WP_156815008.1\|1114417_1115191_-	hypothetical protein	NA	NA	NA	NA
WP_069751283.1\|1115187_1116366_-	hypothetical protein	NA	NA	NA	NA
WP_069751284.1\|1116369_1118436_-	hypothetical protein	NA	NA	NA	NA
WP_156815009.1\|1118432_1119479_-	hypothetical protein	NA	NA	NA	NA
WP_069751285.1\|1119412_1120972_-	hypothetical protein	NA	NA	NA	NA
WP_069751286.1\|1120971_1122699_-	hypothetical protein	NA	NA	NA	NA
WP_069751287.1\|1123133_1125425_-	sigma-54 interaction domain-containing protein	NA	NA	NA	NA
WP_156815010.1\|1125496_1125691_-	hypothetical protein	NA	NA	NA	NA
WP_006412423.1\|1125916_1126909_-\|transposase	IS5-like element ISBmu2 family transposase	E5E3P6	Burkholderia_phage	5.3e-161	85.5
WP_006412423.1\|1127130_1128123_-\|transposase	IS5-like element ISBmu2 family transposase	E5E3P6	Burkholderia_phage	5.3e-161	85.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP016442

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP016442_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016442_1

1689381-1689546

Orphan

Consensus_repeat	Method
CCGGCCGGATCGCCGTTGCCGAGCGTGCCAGTGA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP016442_1

>merge|NZ_CP016442|1|1689381-1689546|PILER-CR
CCGGCCGGATCGCCGTTGCCGAGCGTGCCGGCGAGTTGCGTAACGACGCCCTGGACCGGTGCCAGCGGGCCGCCCGCGCCGCCGACGTTGCCGAGCGTGCCCGTGATCGTGTTGACCGCGTTGCTCAGTGCGCCGGCCGGGTTGCCGCTGCCGAGCGTGCCAGTGA

>NZ_CP016442|1|1|1689381-1689546|PILER-CR
CCGGCCGGATCGCCGTTGCCGAGCGTGCCGGCGA	GTTGCGTAACGACGCCCTGGACCGGTGCCAGCGGGCCGCCCGCGCCGCCGACG
TTGCCGAGCGTGCCCGTGATCGTGTTGACCGCGT	TGCTCAGTGCGCCGGCCGGGTTGCCG
CTGCCGAGCGTGCCAGTGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016442.1\|WP_069746050.1\|1693242_1694022_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270421
NZ_CP016442.1\|WP_069746043.1\|1685383_1686016_-\|DUF1571-domain-containing-protein	unknown	unknown	gnl\|CDD\|225390
NZ_CP016442.1\|WP_069746047.1\|1687779_1688139_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226765
NZ_CP016442.1\|WP_069746055.1\|1698939_1699728_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_CP016442.1\|WP_069746041.1\|1683743_1684793_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_CP016442.1\|WP_069746038.1\|1679699_1681007_+\|deferrochelatase/peroxidase-EfeB	unknown	unknown	gnl\|CDD\|273606
NZ_CP016442.1\|WP_069746049.1\|1691929_1693174_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NZ_CP016442.1\|WP_069746039.1\|1681079_1682114_+\|iron-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270261
NZ_CP016442.1\|WP_069746056.1\|1699863_1701702_-\|peptidase-S1	unknown	unknown	gnl\|CDD\|225490
NZ_CP016442.1\|WP_069746046.1\|1687236_1687752_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|237123
NZ_CP016442.1\|WP_069746044.1\|1686012_1686429_-\|quinol-oxidase	unknown	unknown	gnl\|CDD\|259885
NZ_CP016442.1\|WP_069746051.1\|1694403_1695366_+\|ornithine-cyclodeaminase-family-protein	unknown	unknown	gnl\|CDD\|225280
NZ_CP016442.1\|WP_069746057.1\|1702313_1704404_-\|D-(-)-3-hydroxybutyrate-oligomer-hydrolase	unknown	unknown	gnl\|CDD\|313759
NZ_CP016442.1\|WP_069746052.1\|1695362_1696157_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225512
NZ_CP016442.1\|WP_069746054.1\|1697216_1698656_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP016442.1\|WP_069746040.1\|1682116_1683715_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
NZ_CP016442.1\|WP_069746053.1\|1696345_1697077_+\|DsbA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|239322
NZ_CP016442.1\|WP_069746042.1\|1684811_1685327_-\|polyketide-cyclase	unknown	unknown	gnl\|CDD\|176866
NZ_CP016442.1\|WP_069746045.1\|1686457_1687240_-\|anti-sigma-factor	unknown	unknown	gnl\|CDD\|227949
NZ_CP016442.1\|WP_069746058.1\|1704542_1704908_-\|BON-domain-containing-protein	unknown	unknown	gnl\|CDD\|335963

Protein	Function_ID	Function_description	E-value
NZ_CP016442.1\|WP_069746050.1\|1693242_1694022_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270421	cd13703, PBP2_HisJ_LAO, Substrate binding domain of ABC-type histidine- and lysine/arginine/ornithine transporters; the type 2 periplasmic-binding protein fold. This subgroup includes the periplasmic-binding proteins, HisJ and LAO, that serve as initial receptors in the ABC transport of histidine and lysine-arginine-ornithine amino acids. They are belong to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.98588e-117
NZ_CP016442.1\|WP_069746043.1\|1685383_1686016_-\|DUF1571-domain-containing-protein	gnl\|CDD\|225390	COG2834, LolA, Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane].	2.37951e-07
NZ_CP016442.1\|WP_069746047.1\|1687779_1688139_-\|hypothetical-protein	gnl\|CDD\|226765	COG4315, COG4315, Uncharacterized protein conserved in bacteria [Function unknown].	5.02636e-38
NZ_CP016442.1\|WP_069746055.1\|1698939_1699728_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.99252e-24
NZ_CP016442.1\|WP_069746041.1\|1683743_1684793_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	4.44241e-117
NZ_CP016442.1\|WP_069746038.1\|1679699_1681007_+\|deferrochelatase/peroxidase-EfeB	gnl\|CDD\|273606	TIGR01412, Probable_deferrochelatase/peroxidase_EfeN, Tat-translocated enzyme. This model represents a small family of proteins with a typical Tat (twin-arginine translocation) signal sequence, suggesting that the family is exported in a folded state, perhaps with a bound redox cofactor. Members of this family show homology to Dyp, a dye-decolorizing peroxidase from Geotrichum candidum that lacks any typical heme-binding site.	5.3208e-152
NZ_CP016442.1\|WP_069746049.1\|1691929_1693174_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	1.01635e-48
NZ_CP016442.1\|WP_069746039.1\|1681079_1682114_+\|iron-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270261	cd13543, PBP2_Fbp, Substrate binding domain of ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. This periplasmic protein (Fbp) has high affinities for ferric iron and serves as the primary receptor for transport. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.33869e-140
NZ_CP016442.1\|WP_069746056.1\|1699863_1701702_-\|peptidase-S1	gnl\|CDD\|225490	COG2939, COG2939, Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism].	4.81614e-125
NZ_CP016442.1\|WP_069746046.1\|1687236_1687752_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|237123	PRK12511, PRK12511, RNA polymerase sigma factor; Provisional.	2.16628e-39
NZ_CP016442.1\|WP_069746044.1\|1686012_1686429_-\|quinol-oxidase	gnl\|CDD\|259885	cd04223, N2OR_C, The C-terminal cupredoxin domain of Nitrous-oxide reductase. Nitrous-oxide reductase participates in nitrogen metabolism and catalyzes the last step in dissimilatory nitrate reduction, the two-electron reduction of N2O to N2. It contains copper ions as cofactors in the form of a binuclear CuA center at the site of electron entry and a tetranuclear CuZ centre at the active site. The C-terminus of Nitrous-oxide reductase is a cupredoxin domain.	2.58598e-05
NZ_CP016442.1\|WP_069746051.1\|1694403_1695366_+\|ornithine-cyclodeaminase-family-protein	gnl\|CDD\|225280	COG2423, COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism].	7.46704e-64
NZ_CP016442.1\|WP_069746057.1\|1702313_1704404_-\|D-(-)-3-hydroxybutyrate-oligomer-hydrolase	gnl\|CDD\|313759	pfam10605, 3HBOH, 3HB-oligomer hydrolase (3HBOH). D-(-)-3-hydroxybutyrate oligomer hydrolase (also known as 3HB-oligomer hydrolase) functions in the degradation of poly-3-hydroxybutyrate (PHB). It catalyzes the hydrolysis of D(-)-3-hydroxybutyrate oligomers (3HB-oligomers) into 3HB-monomers.	0
NZ_CP016442.1\|WP_069746052.1\|1695362_1696157_+\|hypothetical-protein	gnl\|CDD\|225512	COG2964, COG2964, Uncharacterized protein conserved in bacteria [Function unknown].	4.81543e-71
NZ_CP016442.1\|WP_069746054.1\|1697216_1698656_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.78299e-63
NZ_CP016442.1\|WP_069746040.1\|1682116_1683715_+\|iron-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	2.38511e-90
NZ_CP016442.1\|WP_069746053.1\|1696345_1697077_+\|DsbA-family-oxidoreductase	gnl\|CDD\|239322	cd03024, DsbA_FrnE, DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins.	5.3714e-82
NZ_CP016442.1\|WP_069746042.1\|1684811_1685327_-\|polyketide-cyclase	gnl\|CDD\|176866	cd07824, SRPBCC_6, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	9.14952e-72
NZ_CP016442.1\|WP_069746045.1\|1686457_1687240_-\|anti-sigma-factor	gnl\|CDD\|227949	COG5662, COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription].	2.40821e-25
NZ_CP016442.1\|WP_069746058.1\|1704542_1704908_-\|BON-domain-containing-protein	gnl\|CDD\|335963	pfam04972, BON, BON domain. This domain is found in a family of osmotic shock protection proteins. It is also found in some Secretins and a group of potential haemolysins. Its likely function is attachment to phospholipid membranes.	7.71006e-09

>NZ_CP016442.1|WP_069746047.1|1687779_1688139_-|hypothetical-protein
MKRILFAAALTAAIVQPAAAEPPQAAAGKLVDEDHMTLYVFDRDAPGKSACDSACATNWPPAIADAYDKASGAWSLVARDDGKKQWAYHGRPLYRWKMDHKAGEMGGDGIGGMWHVARP
>NZ_CP016442.1|WP_069746046.1|1687236_1687752_-|sigma-70-family-RNA-polymerase-sigma-factor
MSYESDLLVWLPHLTRYARALTGDRAWADDLVQDTLERALNRPPRDGGNLRAWLLTLLRHRFIDQLRARHEIAVDDATAPWQTMAAPTGEIGGLMLRDVQRALYRLPVEQREVLLLVALEELSYRDAAQVLGVPVGTVMSRLARARGQMRALLSDEPSAHGSAALRVIGKT
>NZ_CP016442.1|WP_069746045.1|1686457_1687240_-|anti-sigma-factor
MMDDSRKPSNDRDDDASAQLLSALLDGELSGNERREVLERLQSDPEEAERFAHYRAQRDALQALFPLPGAASALFVQRRLSRRRGIAYACAGLAAGLLIGIALHAGWTAFGSEPAFAARADVAYAVYAADREDPVEVGAGDRGRLDAWLSARVGRPVRAPSLDEYGYALLGGRLLPGEAGPAAQLMYQRADGERVTLYMTAYDARRLAPQAMSADGRYTYFWSDRGMGYALSGRGDERRLRELAIEACGALGGSTDAWKG
>NZ_CP016442.1|WP_069746044.1|1686012_1686429_-|quinol-oxidase
MKTMAKMLVPAMLAASVALARADGDAPVRVPVDADGVQRVAIVGGSYFFRPNHVIVRAHVPVELTVSTEPGLVPHSFEIDAPQAGIAVHTELGTTPKTFRFTPAQPGRFAYYCTHRLLFLRSHRERGMEGVLDVEAAP
>NZ_CP016442.1|WP_069746043.1|1685383_1686016_-|DUF1571-domain-containing-protein
MIAALLAASLIGASMTADPVTVAQAHFDHVRSYRATIRSSARGGEHTEIHYAYLKPGFVRMDFVSPHHGAVLAYDPGDGKVRLRPFGAHAPPALTLSPSNPLVRDRSGHRVDRSDVGELLRNVHALQQGGATVTEGEEAVGGRTALRVSVTGAPAHAVDGVHRYRLWLDTEDGFPLKVVSFADDGDEPLETVTLDDVEIDVAFPERFFSP
>NZ_CP016442.1|WP_069746042.1|1684811_1685327_-|polyketide-cyclase
MAQYRFSTTWRVDAPLAAVWDAIYQVDRWPDWWKGAVRTVEIEPGDARGVGALHRYTWKGALPYRLTFDMRVRRVEPPHALEGRASGAIEGDGRWSFAADGARTVVRYDWHIRTHLKWMNWLEPVARPLFRWNHDVVMREGAKGLARRLGASVETDGRIYAPVAGAGCADA
>NZ_CP016442.1|WP_069746041.1|1683743_1684793_+|ABC-transporter-ATP-binding-protein
MSELRIHGLSKSFGSHTVLHDIDLTVRRGSRLALLGPSGSGKTTLLRVLCGFERAERGTVEIDGRRVAAPDVHLPPEQRRIGYVPQEGALFPHLSVADNIAFGLPRAARRRHHRVDELLEMVGLPASYASRVPQQLSGGQQQRVALARALAPEPSLVILDEPFSALDTSLRHETRSAVADALAAAGATSVLVTHDQPEAMTLGDEVAVMWQGRLVQTAAPQMLYRQPVTRDVASFVGQAVLLAGRVHGGRITCALGELPLVAPLPDGPADAMLRPEQIGIVPAAHVDAARGHTARVEAAQFAGQDADVLVRLDADADTFVRARVPGHRCPTVGERVALVVDGAVMAYAR
>NZ_CP016442.1|WP_069746040.1|1682116_1683715_+|iron-ABC-transporter-permease
MSDAVSRTARAARDGKRTATRRRPSRALVAAAACGPLAILLPLGFTLYRAATFGFDDAIELLWRPLVGELLVNTLSITLAATVACALLGTALAWFIERTDLPARPLWTALAAAPLAVPPFITSYAWVSLSLDLQDFLGALIVLTSAYFPLVYLPVAAALRELDPALEESARTLGCSPWHTFFRVVLPQLRPALCGGMLLVALGVLSEFGAFQLLRFRTFTTEIYAEYRTAFDGGGASLLGCVLIALCLLCLAIEARARGHARYGHTHRAARRVAMRYPLGRWRLPAAAAFAALAAATLGVPLGMIGYWLTQQGAAAVTPADVSPELLWQTALASSGYGLVAAAVTTLLALPLAFLLVRYPGRVATLLERTAMTVQGVPGIVVALAIVSLTVRLLQPLYQSAPALVGAYAILFLPLAVVSVRAALSHVQVRLEETARSLGLGWRATLTRVVLPLAAPGLGAAATMVFISVVTELNATLLLSPIGTRTLATQVWSDTATLAFAAAAPYAALLVALSLGASGLLFLLLGRASVRD
>NZ_CP016442.1|WP_069746039.1|1681079_1682114_+|iron-ABC-transporter-substrate-binding-protein
MKTSPVSRPLRHLISAAAAALMLTGALHAARAHAATLTLYNAQHEQVVNQLVKDFEAQSGITVKVRSGEGPALAAQLVAEGDRTPADVYFTENSPELVLLDRKGLLAKTDGAALQAVPARFNPADGNWVGVLARENVLVYNTAKLQPQQLPASLLDLAKPEWKGKVGVAPSDADFLPLVSAVLALHGEAATLQWLKGLKTNAQIFDDDEGVTAAVNRGGVLTGIINNYYWDRLHAELGDKSTKSAIHHFGNHDVGAAVNVSGAAVLKASKHQADAQKFVAYLVSERAQKLMAGGHISFEYPLHPGVAPDPILKPFNELSPPALTFEQLGDDSQAGKLLRQAGLL
>NZ_CP016442.1|WP_069746038.1|1679699_1681007_+|deferrochelatase/peroxidase-EfeB
MADDQNPPSRPARRGFLKAGGAAVAAGLAAGTMPAARAADTAAPAAPDAHAHDDDLEPFYGKHQSGITTPQQRNAYFAALDLSTDKRADVIALLKTWTDAAARLTRGDTAQPLPATGGDEAVPPDSGDALGIGASRLTITFGFGPGLFAVAGKDRYGLAKQRPAALVDLPRFNGDQLIPEKTGGDLFIQACANDAQVAFHAVRQLVRLGGKTVQMRWGQAGFTSGKPGETPRNLMGFKDGTMNPSRDDPATMNEFVWAGSEGPAWMNGGTYTVVRRIRITLEHWDNTELGFQEQVFGRKKYSGAPLGGKQEFEALDLDAVDKDGNSVIPDNAHARLASPQLNNGAQILRRAYSYNDSANFYIERWPPWRQQTEYDAGLMFVAHQRDPRKGFIPINEKLAKLDIMNQFTTHVGSAIFACPPGAQPGSYIGAALFEA
>NZ_CP016442.1|WP_069746049.1|1691929_1693174_-|FAD-binding-oxidoreductase
MDFDVIVLGAGIVGVSSALHLQDRGLRVALVDRREPGEETSHGNAGLIERSSVVPYAFPRRLGTLLRYARNRSVDLYWDYRALPAYAGWLARFWRESSPQRLAAAARDLLPLVEASVVEHDALLARTDAQPLVHDGGWIEAFRSPALFDAEARVQQRVADAHGLRMTVLDARALRDREPGVSDAFCGAFHWQDPKTVSSPGGLTKAYARLFERDGGTFVLGDATTLAQVDDGWRVGTAHGPISARSAVVALGPWSDHVFAPLGYRIPLRAKRGYHMHYQPTRTPLTVPVCDTEEGFVVAPMDGGRLRLTTGVEIALRGAPPTGVQLARAEPLARDAFGIGERLDPEPWLGMRPCTPDMRPVIGPAPRHRHLWFAFGHCHHGLTLGPATGRLLAEMMTGAPTYIDPHPYRPARFG
>NZ_CP016442.1|WP_069746050.1|1693242_1694022_-|ABC-transporter-substrate-binding-protein
MNWKLSLCAAAALACAAVTAHAEQTTLRFGIEAAYPPFESKTPAGQLQGFDVDIGNAVCAKLNMKCVWVENSFDGLIPALQARKFDAINSAMNITAKRRQSIDFTPAIYVVPIVMVAKRGSPLRPDVASLRGKHVGVLQGSSQEDFLKAHWANAGVAVVSYQDQDQIYADLVAGRLDAAVQEAQTAQDGFLDKPAGRDYQIVGEALKDPATLGEGTGFGMRKNDKALQAKIVGALDALKKDGTLSALSQKYFKRDIVAK
>NZ_CP016442.1|WP_069746051.1|1694403_1695366_+|ornithine-cyclodeaminase-family-protein
MTQTVPPLPLTVDEAAVRAALPSLDVLGTLRRMFASLASARAVQPPQTLTLFPDQAGDFITYLGALADEQVFGAKLSPYVVTGGKPIVTAWTALMSMRTGQPLMWCDAGLLTVERTAGTTALAVDCLAPCDARHLAIVGAGAVGLAHLRHTAALRDWEKIRVYSPALAGDAALQATLAQLDPRARAAASVDACVRDADVVMLCTSSGTPVLGDGMLTRPALVTSISTNVARAHEIPPAWLPDMDVYCDYRHTTPASAGEMQIAAADHGWAAERIVGDLPALVAGTCAAPSRARHAFFRSIGLGLEDIAIAHALYTHLTRA
>NZ_CP016442.1|WP_069746052.1|1695362_1696157_+|hypothetical-protein
MSITRARGRYNGATAAAAARGRTGMPATGAPARRPDAPPGPRPPEMATPMRKKQSPVKDLLLTRYAPIADGIAALFFPYAEVVIHDLHDQTVLYLANNLSKREIGDDSALEEIDHSARERVIGPYEKLNWDGRRMRCVSNVLFDDEGRPAGMMCINFNIAVFDEVRATLDLFIKGAGVVAQPDELFRDDWQERINTFLHGWLRERQVGLNGLTREHRRELVEALYAEGAFRGKSAANYVANVLGMGRATVYKHLKHLKETQGDA
>NZ_CP016442.1|WP_069746053.1|1696345_1697077_+|DsbA-family-oxidoreductase
MTTAPAPTARPTLTVEIWSDLICPWCWIGKRRFDEALARFAHADRVDVALRAYRLMPGQPVEPVEAMLAGKYRMSPAQVDQMLRQVTDAAASVGLHYDLPGTLVGDTLDGHRLVKLAEATGRAHTLTERLYRAYFCEHGSLFDHAELTEFAVEAGLERAAVEDVLRSDLYRDEVEADIARAAQIGGRGVPLFVFGGRYAVSGAQPADAFEQALDQAWRDGIVELAGDDAAACGPDGCALPARS
>NZ_CP016442.1|WP_069746054.1|1697216_1698656_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MTHGIHGEKRWYALIVLCLGVLMIVLDSTIVNVALPSISTDLHFTETALVWVVNAYLLTFGGCLLLGGRLGDLYGQRRMFLAGLVVFTLASLACGLAQSQTMLIAARAVQGLGGAVVSAVSLSLIMNLFTEPGERARAMGVYGFVCAGGGSIGVLLGGLLTSSLSWHWIFLVNLPIGIAVYAMCAALLPRMRAPAGAARLDVAGAITVTGSLMLAVYGIVGGNEAGWLSTQTVALIGAAIALLALFIAIEARAAHPLMPLTLFAARNVALANVIGVLWAAAMFAWFFLSALYMQRVLGYGPLQVGLAFLPANLIMAAFSLGLSARIVMRFGIRGPIAAGLLIAACGLALFSRAPVDGGFVGHVLPGMTLLGIGAGVAFNPMLLAAMSDVDPADSGLASGIVNTAFMMGGALGLAVLASLAAARTDALAAAQAAPLDALNGGYHAAFAFGAAFAVAAALIGLALRIRRQGAVEGVGPATH
>NZ_CP016442.1|WP_069746055.1|1698939_1699728_+|sulfite-exporter-TauE/SafE-family-protein
MSLPHIDLLYSLSGLFVGILVGLTGVGGGSLMTPILVLLFGVHPATAVGTDLLYAAATKATGTLVHGLKGSIDWRITGRLAAGSVPAAALTLWWLHTHGMNTPGTARMIQLVLGIALLLTSLALIFRPQLTAFAARNPLAPSPARTLWSTVLTGAVLGVLVSMTSVGAGAIGVTVLLLLYPMLATSRIVGSDIAHAVPLTLVAGMGHWLLGSVDWSMLLSLLLGSLPGIVLGSLLSARAPERLLRNLLAATLVAVGVRLVLA
>NZ_CP016442.1|WP_069746056.1|1699863_1701702_-|peptidase-S1
MTTRKSLKDGFALFGTTLSVPLAAAAAAALLVTGCGGDDGPSPSASAAAAAATTSNGSSSASTNATAAAAADQPYVDTDVYGTGPNDAVTDSTEGAAVVHRQVTIGGKTIKYTATTGHLTTIDPATSAPNAKMFYVAYTQDNPDPSKPRPVTFFYNGGPGSSSVYLLLGSYGPKRLQSSFPNFTPPAPYKLLDNPDSLLDRTDLVFINPVGTGYSTAVAPAKNKDFWGTDQDARSIDRFIQRYLTKYSRWNSPKFLYGESYGTARSAVVSWVLHEDGIDLNGITLQSSILDYANALSAPGTFPTLAADAFYWKKTTLNPTPTDLDAYMVQARNYADNTLAPLAQKPNPQDGGFVNVRLNLNLQTAQQMGSYIGTDPTSLIQTFGNPAALGNVPSSNDNPPYTFFLTLVPGTQIGQYDGRANFTGKGIAPYILPNSGSNDPSISNVGGAYTVLWNSYINTDLKYTSTSSFVDLNDQVFNNWDFSHTDPTGANKGGGNTLYTAGDLASTMSVNPDLKVLSANGYFDAVTPFHQTELTLAQMPLDPTIKAQNLTIKNYPSGHMIYLNDASRTALKGDLANFYDGILANRTALQRVLKLQARTQQLKQQQLQQQGQ
>NZ_CP016442.1|WP_069746057.1|1702313_1704404_-|D-(-)-3-hydroxybutyrate-oligomer-hydrolase
MARLGWGRRMVFGAALAAVAMLGACNGDDSGERNRLPAFVSGSVRTTAYDGASDDLLTAGLGKTGLGTASAPGFANASRPTSAELRRLAIWSNYRALVDMSANGGYGRFWGPNVDLDGNDTLGEGKIPGTEYLAYSDDGSGTKNVTLLVQVPASFDPAQPCIVTATSSGSRGVYGAISAAGEWALKRGCAVAYNDKGGGNGAHELGSDTVTLIDGTLANAVLAGTASLFTANVTSGDLAAFNNRFPNRYAFKHAHSQQNPEQDWGRVTLQSVEFAYWALNEQFGPLIDGSHHGVRYRAGDITTIAASVSNGGGASLAAAEQDTRGWITAVVVGEPQINVRMAPNAIVRTGGQPVPSFGRPLADYATLANLLEPCAAASASLAGAPYLSALPAATTQSIRTQRCATLAAAGLVSGGDTQSQAADALAQLHAAGYLADSDLLQAPMWDSQAIPAIAVTYANAYTRSRVTDNLCNFSFATTSAATGTVAPPAASPMPAVFGLGNGVPPTAGIDLVFNTGAGVDHRLATPDASFAGALCLRQLWTNGMLGMPANVDAVRVNANLQGKPAIIVQGRNDALVPVNHASRAYVAQNGISEGSRSQLVFYEVTNGQHFDAFLPVAGFDTRFVPVHYYNLQALNLMWRHLKNGAPLPPSQVIRTVPRGGTPGAAPALTSANLPPISAAPGANAITAGAGAIDVPL
>NZ_CP016442.1|WP_069746058.1|1704542_1704908_-|BON-domain-containing-protein
MKSIVLRALGVAAVAACLSGSVYAQSSDAAATEAPAAATSAPKAAAKTAKKANRKLGYAVRKAISKESGVNVSNLVVRSKGGAITLEGTMPEQAQIDKAEAAAKGVKGVTSVANKLTVQQQ

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Crispr_ID: NZ_CP016442_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP016442_2

1822964-1823082

Orphan

Consensus_repeat	Method
TCAGCCTCCGCCGGGCCGCCCCAAGGGGGCTGACCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP016442_2

>merge|NZ_CP016442|2|1822964-1823082|CRISPRCasFinder
TCAGCCTCCGCCGGGCCGCCCCAAGGGGGCTGACCGCCCCCGCGGGGGCAGCGAACGAAGTGAGCGTGGGGGTCGTTTCATCTCAGCCTCCGCCGGGCCGCCCCAAGGAGGCTGACCGC

>NZ_CP016442|2|1|1822964-1823082|CRISPRCasFinder
TCAGCCTCCGCCGGGCCGCCCCAAGGGGGCTGACCGC	CCCCGCGGGGGCAGCGAACGAAGTGAGCGTGGGGGTCGTTTCATC
TCAGCCTCCGCCGGGCCGCCCCAAGGAGGCTGACCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP016442.1\|WP_069746135.1\|1821083_1821512_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP016442.1\|WP_069746144.1\|1836351_1837818_+\|metalloprotease-TldD	unknown	unknown	gnl\|CDD\|182685
NZ_CP016442.1\|WP_069746137.1\|1822554_1822962_-\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|224109
NZ_CP016442.1\|WP_069746145.1\|1838216_1839290_+\|3-deoxy-7-phosphoheptulonate-synthase-AroG	unknown	unknown	gnl\|CDD\|236435
NZ_CP016442.1\|WP_069746141.1\|1828157_1830959_-\|bifunctional-[glutamate--ammonia-ligase]-adenylyl-L-tyrosine-phosphorylase/[glutamate--ammonia-ligase]-adenylyltransferase	unknown	unknown	gnl\|CDD\|236836
NZ_CP016442.1\|WP_069746133.1\|1817579_1818716_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|236757
NZ_CP016442.1\|WP_069746140.1\|1826406_1828056_+\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
NZ_CP016442.1\|WP_069746130.1\|1813952_1814639_+\|deoxynucleoside-kinase	unknown	unknown	gnl\|CDD\|238836
NZ_CP016442.1\|WP_069746131.1\|1814682_1815498_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234723
NZ_CP016442.1\|WP_069746132.1\|1815643_1817575_-\|bifunctional-anthranilate-synthase-component-I-family-protein/class-IV-aminotransferase	unknown	unknown	gnl\|CDD\|223225
NZ_CP016442.1\|WP_069746143.1\|1835438_1836266_+\|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|143596
NZ_CP016442.1\|WP_069746139.1\|1825483_1826386_+\|NAD-kinase	unknown	unknown	gnl\|CDD\|179379
NZ_CP016442.1\|WP_006476841.1\|1822421_1822583_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP016442.1\|WP_069746142.1\|1831187_1835387_+\|TIGR02099-family-protein	unknown	unknown	gnl\|CDD\|273971
NZ_CP016442.1\|WP_069746129.1\|1813413_1813956_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|223872
NZ_CP016442.1\|WP_069746136.1\|1821522_1822068_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|237621
NZ_CP016442.1\|WP_069746134.1\|1818982_1820935_-\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NZ_CP016442.1\|WP_011544637.1\|1824329_1825352_-\|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
NZ_CP016442.1\|WP_069746138.1\|1823128_1824193_-\|ferrochelatase	unknown	unknown	gnl\|CDD\|234585
NZ_CP016442.1\|WP_069746146.1\|1839402_1840611_-\|NO-inducible-flavohemoprotein	unknown	unknown	gnl\|CDD\|237337

Protein	Function_ID	Function_description	E-value
NZ_CP016442.1\|WP_069746143.1\|1835438_1836266_+\|carbon-nitrogen-hydrolase-family-protein	gnl\|CDD\|143596	cd07572, nit, Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases). This subgroup includes mammalian Nit1 and Nit2, the Nit1-like domain of the invertebrate NitFhit, and various uncharacterized bacterial and archaeal Nit-like proteins. Nit1 and Nit2 are candidate tumor suppressor proteins. In NitFhit, the Nit1-like domain is encoded as a fusion protein with the non-homologous tumor suppressor, fragile histidine triad (Fhit). Mammalian Nit1 and Fhit may affect distinct signal pathways, and both may participate in DNA damage-induced apoptosis. Nit1 is a negative regulator in T cells. Overexpression of Nit2 in HeLa cells leads to a suppression of cell growth through cell cycle arrest in G2. These Nit proteins and the Nit1-like domain of NitFhit belong to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 10.	6.57697e-151
NZ_CP016442.1\|WP_069746144.1\|1836351_1837818_+\|metalloprotease-TldD	gnl\|CDD\|182685	PRK10735, tldD, protease TldD; Provisional.	0
NZ_CP016442.1\|WP_069746137.1\|1822554_1822962_-\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	1.29575e-29
NZ_CP016442.1\|WP_069746145.1\|1838216_1839290_+\|3-deoxy-7-phosphoheptulonate-synthase-AroG	gnl\|CDD\|236435	PRK09261, PRK09261, phospho-2-dehydro-3-deoxyheptonate aldolase; Validated.	0
NZ_CP016442.1\|WP_069746141.1\|1828157_1830959_-\|bifunctional-[glutamate--ammonia-ligase]-adenylyl-L-tyrosine-phosphorylase/[glutamate--ammonia-ligase]-adenylyltransferase	gnl\|CDD\|236836	PRK11072, PRK11072, bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase.	0
NZ_CP016442.1\|WP_069746133.1\|1817579_1818716_-\|molecular-chaperone-DnaJ	gnl\|CDD\|236757	PRK10767, PRK10767, chaperone protein DnaJ; Provisional.	0
NZ_CP016442.1\|WP_069746130.1\|1813952_1814639_+\|deoxynucleoside-kinase	gnl\|CDD\|238836	cd01673, dNK, Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.	8.10135e-64
NZ_CP016442.1\|WP_069746140.1\|1826406_1828056_+\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	0
NZ_CP016442.1\|WP_011544637.1\|1824329_1825352_-\|heat-inducible-transcriptional-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	1.99174e-153
NZ_CP016442.1\|WP_069746131.1\|1814682_1815498_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl\|CDD\|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	3.29601e-169
NZ_CP016442.1\|WP_069746132.1\|1815643_1817575_-\|bifunctional-anthranilate-synthase-component-I-family-protein/class-IV-aminotransferase	gnl\|CDD\|223225	COG0147, TrpE, Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism].	4.50017e-113
NZ_CP016442.1\|WP_069746139.1\|1825483_1826386_+\|NAD-kinase	gnl\|CDD\|179379	PRK02155, ppnK, NAD kinase.	0
NZ_CP016442.1\|WP_069746135.1\|1821083_1821512_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.18546e-09
NZ_CP016442.1\|WP_069746142.1\|1831187_1835387_+\|TIGR02099-family-protein	gnl\|CDD\|273971	TIGR02099, probable_transmembrane_protein, TIGR02099 family protein. This model describes a family of long proteins, over 1250 amino acids in length and present in the Proteobacteria. The degree of sequence similarity is low between sequences from different genera. Apparent membrane-spanning regions at the N-terminus and C-terminus suggest the protein is inserted into (or exported through) the membrane. [Hypothetical proteins, Conserved].	7.35417e-165
NZ_CP016442.1\|WP_069746129.1\|1813413_1813956_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	5.39277e-61
NZ_CP016442.1\|WP_069746136.1\|1821522_1822068_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|237621	PRK14139, PRK14139, heat shock protein GrpE; Provisional.	7.19666e-97
NZ_CP016442.1\|WP_069746134.1\|1818982_1820935_-\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_CP016442.1\|WP_069746138.1\|1823128_1824193_-\|ferrochelatase	gnl\|CDD\|234585	PRK00035, hemH, ferrochelatase; Reviewed.	1.76583e-169
NZ_CP016442.1\|WP_069746146.1\|1839402_1840611_-\|NO-inducible-flavohemoprotein	gnl\|CDD\|237337	PRK13289, PRK13289, NO-inducible flavohemoprotein.	0

>NZ_CP016442.1|WP_069746137.1|1822554_1822962_-|RNA-binding-S4-domain-containing-protein
MNYKISTEPGAKLRIDKWLWAARFFKTRSLATDAVDKGHVKIGGAAIKPAKEVRVGDEVEIAIDGIVWHIAVLGVCDVRGPASVAQTLYEETEAGRAARLAELERRRTYREPAAELHGRPTKRDRRIIDRFSGGS
>NZ_CP016442.1|WP_006476841.1|1822421_1822583_+|hypothetical-protein
MKLTFAISVVALVLIAGTTTICLSGAVTDRTTEYGSARATFDQMFSSHQKICR
>NZ_CP016442.1|WP_069746136.1|1821522_1822068_-|nucleotide-exchange-factor-GrpE
MENTQENPATQSADDIGSEKQAAQGAAPAAEAADAALAEAQAKVAELQESFLRAKAETENVRRRAQDDVSKAHKFAIEGFAEHLLPVLDSLEAAVSDTSGDIVKVREGIELTLRQLTNALEKGRVVAINPVGEKFDPHQHQAISMVPAEQEPNTVVAVLQKGYTIADRVLRPALVTVAQPK
>NZ_CP016442.1|WP_069746135.1|1821083_1821512_-|thioredoxin-family-protein
MVPAGVDPAAFDAFGMQALAPDTFDAGIEGAGDALAVVFFWGVDCFNCEIAKKSMLAQPDAIRALDLKWFHCNVYEHAELGRRFGLHGVPTWFFFHRGKRLGRATGWHGLGQFQAAVSAARGKIAAAAGHDPAPGDPLAGGD
>NZ_CP016442.1|WP_069746134.1|1818982_1820935_-|molecular-chaperone-DnaK
MGKIIGIDLGTTNSCVAIMEGNQVKVIENSEGARTTPSIIAYMDDNEVLVGAPAKRQSVTNPKNTLFAVKRLIGRRFEEKEVQKDIGLMPYAIVKADNGDAWVEAHGEKLAPPQVSAEVLRKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKVEKGDRKIAVYDLGGGTFDVSIIEIADVDGEMQFEVLSTNGDTFLGGEDFDQRIIDYIIGEFKKEQGVDLSKDVLALQRLKEAAEKAKIELSSGQQTEINLPYITADASGPKHLNLKITRAKLEALVEDLVERTIEPCRIAIKDAGVKVSDIDDVILVGGQTRMPKVLEKVKEFFGKDPRRDVNPDEAVAVGAAIQGQVLSGDRKDVLLLDVTPLSLGIETLGGVMTKMINKNTTIPTKHAQVYSTADDNQGAVTIKVFQGEREMAAGNKLLGEFNLEGIPPAPRGVPQIEVTFDIDANGILHVGAKDKATGKENKITIKANSGLSEAEIDQMIKDAEANAAEDHKLRELADSRNQGDALVHSTKKALTEYGDKLDAGEKEAIEAALKSLEEVLKDTSADKAAIDAKVEELGKVSQKLGEKMYADMQAQQAGAAGAAGAAEGAAHAGGAQQAADDVVDAEFKEVKKD
>NZ_CP016442.1|WP_069746133.1|1817579_1818716_-|molecular-chaperone-DnaJ
MAKRDYYEVLGVAKNASDDEIKKAYRKLAMKYHPDRNPDNKDAEEHFKEVKEAYEMLSDSQKRAAYDQYGHAGVDPNMGGAGAQGFGGFADAFGDIFGDIFGQAAGGAARGGRGGPQVYRGADLRYSMEITLEQAAHGYDTQIRVPSWVSCEVCHGSGAKPGTKPETCPTCHGQGTVRMSQGFFSIQQTCPKCHGTGTYIPEPCVHCHGSGKVKETKTLEVKIPAGIDDGMRIRSAGNGEPGINGGPPGDLYVEIHIKPHSVFERDGDDLHCQMPIPFTTAALGGEIEVPTLAGRASFPVPEGTQSGKTFRLRGKGIKGLRSSIAGDLYVHVQVETPVKLTDHQRDLLKQFEKSLAEGGARHSPQSKSWFDRVKSFFE
>NZ_CP016442.1|WP_069746132.1|1815643_1817575_-|bifunctional-anthranilate-synthase-component-I-family-protein/class-IV-aminotransferase
MTEGSESASFALLDDCDSTASARSSRLYSGFVRERRCADPARLDEIDAAVAQDLRDGLHAVVVGDYEFGRNLQRAQPGHAPLRFLLYARCERLSRDEVDAWLARQDGGGDGGAPSIAGVAHVEKSVTRAAFDAAIGAVHDALRAGDSYQVNYTYRLNFDVFGTPLALYRRLRARQPVRYGALIALPGGEWVVSCSPELFVEKHGDVLRARPMKGTAPRSADPREDAAAAAFLASDPKNRAENVMIVDLLRNDVSRIARTGTVRVPALFSVEPYASVWQMTSTVEAGWRDGTTFAQMLRALFPCGSITGAPKYRTMQLIDAIESTPRGLYTGAIGWLDAPDESADPGASGNRAAGCGDFCLSVAIRTLTLDAGGEGATGADIEALDAAAATAGRRRGTMGVGAGIVLDSIAADEYAECELKARFLTDADPGFQLFETTAATRADGIRHLDRHLARLQRSADAFGFRFDTDALRREIDARCAALDGDGAYRMKLALAKDGTVEITAAPLKPLPAGPIGVLLASEHGFAPTRASDALLLHKTTRRAEYDRAWQAAEALGGFDMLFVNERGEVTEGGRSNLFVKLDGQWVTPPLASGVLPGVMRGVLLDDPAFGATERVVTRDDLARAQALLLTNALRGALDAVLKP
>NZ_CP016442.1|WP_069746131.1|1814682_1815498_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MTYLQESSRPAVTVPKLQAMRDAGEKIAMLTCYDASFSALLDRAGTDVLLIGDSLGNVLQGHTTTLPVSLDDIAYHTACVARAQPRALVVADLPFGTYGTPAEAFANAVTLMRAGAQMVKLEGGEWLAETIRFLVDRSVPVCAHIGLTPQSVHAFGGFKVQGKTEAGAAQLLRDARAVEDAGAQLVVLEAVPTLVASEVTHMLKIPTIGIGAGVDCSGQVLVLHDMLGIFPGKRPRFVKDFMQGQPNIQAAVEAYVSAVKDQTFPGPEHSF
>NZ_CP016442.1|WP_069746130.1|1813952_1814639_+|deoxynucleoside-kinase
MNSTPLTVTVPDLRAPHRYLVIEGPIGVGKTTLARLLAERWSMQTLLERPQDNPFLERFYRDTARYALPVQLSFALQRAQQARELAGALETGRPVIADFMPQKNDIFARLNLPEDEWQLYRSIATHVDVPQAPSPDLVVYLQASPEVLFSRIQKRGLPMELQISDAYLRSLVDAYNEFFYHYDRTPVLTVAAEHLNPLESPEDLALLIERIETMRGRKEFFVKGETAR
>NZ_CP016442.1|WP_069746129.1|1813413_1813956_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MTVAYIGLGANLGDARQTLKDAVVCLAQQRTISVLGKSSLYRTAPFEAGGDDYYNCVVKLDTTLSARELLALCQKIEHHFGRERPYRNAPRTLDLDILLFGSDSIDEPDLIVPHPRLTDRAFALVPLVEIEPALDIPARGRADAFLAAVADQRVEKVQTCQCLMQKALAAGEDADKNPCR
>NZ_CP016442.1|WP_069746138.1|1823128_1824193_-|ferrochelatase
MRFDLEPPSSIAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLLRTLILPLRGRASAKKYAAVWMPEGSPLRVHTERQTDGVRHLLTSNGYHVLVDYAMRYGSPNIAHALAQFKRLGVERVLLMPMYPQYSASTTATAFDAAFDALARMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMAALGLSTTECRVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLAGGGKAFHRIPCLNGAPAWIGAVGEIVAENLQGWPVKAAQPETVS
>NZ_CP016442.1|WP_011544637.1|1824329_1825352_-|heat-inducible-transcriptional-repressor-HrcA
MLDPRARTLLKTLIERYIADGQPVGSRTLSRYSGLELSPATIRNVMSDLEELGLVSSPHTSAGRVPTPRGYRLFVDTMLTVEAPIDAEAVARQVQNTLQAGEPQQRVVAAAASVLSNLSQFAGVVLTPRRSHVFKQIEFMRLSDKRILLIIVTPEGDVQNRMLATPRDYSPSQLTEASNYINAHFAGLSFDEVRRRLRDEIDQLRGDMTTLMHAAVTASTEVPDTEDTVLISGERNLLEVADLSSDMARLRKLFDVFDQKTGLLQLLDVSSHAQGVQIFIGGESTLVPIEEMSVVTAPYEVNGQIVGTLGVIGPTRMAYNRVIPIVDITARLLSLTLSQQ
>NZ_CP016442.1|WP_069746139.1|1825483_1826386_+|NAD-kinase
MKTGNQFNTVALVGRSNTPGIAEPLATLAASLAQLGFEVVFEGDTAREFGITGYPALTPAEIGARADVAVVLGGDGTMLGIGRQLAPYKTPLIGINHGRLGFITDIAAADMHARVPVMLAGKFEREERSLLEARIMRDGEPIYHALAFNDVVVNRSGFSGMVELRASVDGRYMYNQRSDGLIVATPTGSTAYALSSAGPILHPQLQGIVLVPIAPHALSNRPIVLPDDSKIAIQIVGGRDVNVNFDMQSFTALELNDTIEVRRSKHTVPFLHPIGYSYYATLRKKLHWNEHASNEDDKAS
>NZ_CP016442.1|WP_069746140.1|1826406_1828056_+|DNA-repair-protein-RecN
MLRHLSIRDFVIVAALDLEFDSGFSVFSGETGAGKSILIDALALALGERADASVVRAGCGRADITAEFTPHDRVARWLDEHAFDTEDTVMLRRVIDANGRSRAFINGTSATLAQLRELGEMLVDIHGQHAHQLLMRPDAQRELFDTHAGLVADAANVARAWRVWRDATQAIDAAKSHERELQLEREKLAWQLAELDKLAPQAGEWDEVSNEHKRLSHSANLIDGVRGALNALSEADDAMLAQLGAIVSKLRSLADYDTALGDALASLEPAEIQLQEAVYSLSHYAQRVDLDPERLAQVETRLDALHSTARKFRLPPDTLHEEHAARRAQLAALDAAADLGALEATQAKAREAYLADAKHLSKARAQAARALGTAVTAGMQELSMAGGSFEVALVPLADGGPHGLEQVEFRVAGHPGVPLRPLGKVASGGELARISLALAVIASAASPTPTLIFDEVDTGIGGGVAEVVGRLLHQLGRDRQVLCVTHLPQVAARGDHHFQVAKGADDRGGTVSTVVALDRANRIEEVARMLGGLEITATTRKHAKEMLAA
>NZ_CP016442.1|WP_069746141.1|1828157_1830959_-|bifunctional-[glutamate--ammonia-ligase]-adenylyl-L-tyrosine-phosphorylase/[glutamate--ammonia-ligase]-adenylyltransferase
MTDASALISTSYSRYLARAAAARPALAEQVVAWAAAPLARAQLDARLTELLATPAGTAAPTEEQLKRALRQLRAEAFGAVAERDLRGLADVVEVTGAMTDLAEVAVQRSLALLSAELEALYGEPRGADGQRVVLGVVGMGKLGGRELNVSSDIDLIFVYEDDGETTGGARAPLSTQEYFTRLGRRLIGVLSEVTADGYVFRVDMRLRPNGDSGPLVCSLGMLEEYFYVQGREWERYAWIKGRLVSEGDSDAAMRLESQLESIVKPFVYRRYLDFGVIGAIRSLHQQIRQEAARRASMRPDKADDIKLGRGGIREIEFSAQVFQLIRGGQDAEFRVRPTLAVLRHAQARGLIGEDVRARLTDAYNFLRTLEHRLQYRNDAQTHAMPVEPDERAALAASLGFADYAALMTVLDEHRNFVEAQFDQIFADKVNGAPCGAGEETAAAWIWSGALADDGEDDALAARLDGLGFTDPVAVLARLRAVWQSSRYTGLPEKSRHRFDRVAQRALEAAPRIDAARRDDTIVRLFDLLETVSRRGVYLALLTEYPAALDRVLSVLGATRWGGGYLIRHPQLLDELLDDEAIASPFDWPAFKDALRARLAAADGPEQQMDLLRHAQHAEVFRILLIDLAGQLSVEHVSDRLSELADAVLDVTIEVVWSQLAKRHRDVPKFAVIAYGKLGGKELGYASDLDLIFLYDDPDERSADVYTTFTRRLITWLTTATGAGALFDIDLRLRPNGEAGLLVTDLDAFRRYQLREGDAANTAWVWEHQALTRARYSAGDAQIGADFEAIRQQVLTTPRDGGVLAKEIVDMRGKVFAGHPNQTELFDLKHDRGGMVDIEFIVQYWVLLHASSDAELIRNTGNIALLREVARFGLMGEDEAERVGAAYRKYRKLQHKLRLDGMEKARVDPATVADERAAVTALWTRVFGAVETGV
>NZ_CP016442.1|WP_069746142.1|1831187_1835387_+|TIGR02099-family-protein
MSDRQESAVAAPEAGPPKHDHPVLRRVFRVTLAVGIGTYFVASGAFLGLRYVLLPRIDEYRPRIERLVSDKLHAQLSIGKLSPNWSGMQPGVEVTNLTIRGRDGKVALSVPHATAALSWMSLLRLSPALSSLIVDQPDLAVARAADGSLSIAGVGVATTHGGNDTFGTWLLKQEAIVLRGGTLRWRDAQHDAPELVLSGIRIAVLNNGRVHRAALQAPANGTLLLGPLDFRARFTHKALAPVGKPTNWTGDAYLSTGPVDLQTLARYLDIPLTIHAGRIDNAIWATFRDGRLRSAGGDLQGADVTLRVRPTQPRLDVPAVGFGWDMAMDAGHDYTLHLSRFHAELGQPPLDDGTPLARSLALSTLTARYRVPTASQGQLISVVGDRVDLGILSEFIRGLPLPARLRNELIKIDPRGMMSNYQIEVERAKPARAELADEERRTGAAPIVRYRFLGDLQGISFAAQEPPPGLSPRGHPRAGWPGIENLWGRVDASETGGTAHFDTVNAAVTVPGEFDEPRLTFDRLRGNVKWTITPAPGDKHARVDVTLPDLLVSNPDAEIAVSGSYTNPGHGRGTLDLRADFARAAVARIPRYLPTGMSEHLRDYLGHALQDGKVTKGASIVARGPLEKFPFEHEPDAGVFHIVAPFTGGRFEPTPYPPRKLANGTPSVWPALDGIDGVFELKQNKLRFDIDRAHYKRVALTKVAGRIDDLGNPSHSPLIIDGHAQGPLADLIDYADNSSLGTMSGHIGQRIDAQGPASLGLKITIPQHVAHPHTHIEGALAFGGNTLSTRGVPPLSALRGSVKFTEAGASLHELSGRFLGGPVRANGTFQSHGPYAVDVDGKLALDAARGLNLHGAAAALLEHVIGDAPYKVAVRGAPGRLPDITARSDLTGVALNFPAPFAKPAGTPMPFSFTLQPAPQADGKRLEHADLTLGPVSATYLLDATRGQPLRAVRGAMGIHRMPDMPQEGVSAAVDVGELDADAWLALAHTLKPDTPRAPEPQAPSRVDLASFAPKRFALHFGTLKLLKRNWENVIVGASHVDELWQANIASNQVSGYLSWAPGGGHNGAGVLNARLAKLVIPDSAQHDLVGRAMNLPTPTDRPMPSIDLIVDQVVARNHDIGRLVVNARNIDEEGTPVWQLDKLELSNPAAKLTATGNWRTSRRALARGADENDAPRRTVFDFKLDIDNAGALLDRVGLPRTLESGHGTITGKVGWRGGPTAVDFPSFGGQVALDLEHGQILKVDPGAAKLLGVLSLQSLARFLTLNFRDVIGKGLPFDKITGTGQISNGIARTDDFSMMTGPANVTVRGAVDLGTETQDLHAHVAPKISAGAAAIGAAVINPLLGIGVLAANYALSETLSRAFALDYTITGSWAHPHIERVRGDQGKMNHGPADATNH
>NZ_CP016442.1|WP_069746143.1|1835438_1836266_+|carbon-nitrogen-hydrolase-family-protein
MTDHTRSATPFRVAALQMVSTPDVTRNLAEARRLIAEAAGEGAQLVLLPEYFCFMGHRDTDKLALAEPYQDGPIQRFLADAARRHGIWVIGGTLPLKAPEPDRVLNTTLVFDPSGNEAARYDKIHLFNFEKGDESFDEARTIRAGDTVVAFDAPFGRVGLSVCYDLRFPELYRRMGDCALIVVPSAFTYTTGRAHWETLLRARAVENQCYVLAAAQGGKHENGRRTWGHSMLIDPWGEIVAVRDVGASVVLGALDPQRIADVRQSLPAWRHRVLT
>NZ_CP016442.1|WP_069746144.1|1836351_1837818_+|metalloprotease-TldD
MNIIEPGIRNLALAKDILLTPYGLDESLLTRTIADIFTHRVDYADLYFQATRSEAWSLEEGIVKSGSFSIDQGVGVRAVAGDRTAFAYSDDLSPEAIAQAAAATKAIAAAGGGRQKIKAATSLKGISGRDLYLPSDPLASLDATAKVKLLERIEQMARGRDPRIQQVMAGLAGEYDVVLVARSDGALAADIRPLVRVSVTVIAEQNGRREIGSGGGGGRFDYGYFTDEVLSRYVDDAVHAALVNLDARPAPAGAMTVVLGPGWPGVLLHEAIGHGLEGDFNRKGSSAFAGRIGEQVAAKGVTVVDDGTLPNRRGSLNIDDEGNPTQCTTLIEDGILKGYIQDTLNARLMKMPVTGNARRESYAALPMPRMTNTYMLNGDKDPQEIIASVKNGLYAVNFGGGQVDITNGKFVFSASEAYMIENGKITYPVKGATLIGSGPESLKYVSMIGNDMSLDTGVGVCGKEGQSVPVGVGQPTLRIDKMTVGGTA
>NZ_CP016442.1|WP_069746145.1|1838216_1839290_+|3-deoxy-7-phosphoheptulonate-synthase-AroG
MPPHNTDDVRIRELKELTPPAHLIREFACSEAASELIYNSRQSMHRILHGMDDRLIVVVGPCSIHDTKAAIEYAGRLVKERERFKGELEIVMRVYFEKPRTTVGWKGLINDPHLDNSFKINEGLRTARELLLQINEMGLPAATEYLDMISPQYIADLISWGAIGARTTESQVHRELASGLSCPVGFKNGTDGNVKIAVDAIKAASQPHHFLSVTKGGHSAIVSTAGNEDCHVILRGGKTPNYDAESVNAACADIGKAGLAARLMIDASHANSSKKHENQIPVCADIGRQIAAGDARIVGVMIESHLVEGRQDLKEGCELTYGQSITDACIAWDDSVKVLEGLAESVKARRVTRGSGN
>NZ_CP016442.1|WP_069746146.1|1839402_1840611_-|NO-inducible-flavohemoprotein
MTHITADQMARVKATAPVLAVHGATITKHFYQRMFARHPELKNLFNQTHQKTGSQPETLAKAVYAYAANIDNLGVLGGAVSHIAHKHASLNIRPEHYPIVGENLLASIVEVLGDAVDADTLEAWRVAYGQLAQILIGAEADLYAGAAWSGFRPFKVTRKVRESDEITSFYLSPADGGAAPTFESGQYITVKRFVGDLGVDQPRQYSLSDAPHGKWLRISVKREAGRPEEIPAGKVSTLMHDGVEEGAVVEVTAPMGEFSLKRGVDTPVVLISGGVGLTPMVSMASTLAEEGSKRDVRFVHACRSGAVHAFRDWLNDTVREHANVKRTVLYERVGPNDRVGIDHDLEGRLTPERVKEFAIVPNADYYVCGPIAFMKAQRDALVALGVAPERINTEIFGSGALE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP016442_1	1.2\|1689502\|26\|NZ_CP016442\|PILER-CR	1689502-1689527	26	NZ_CP022775	Ralstonia solanacearum strain T12 plasmid unnamed, complete sequence	977995-978020	4	0.846
NZ_CP016442_1	1.2\|1689502\|26\|NZ_CP016442\|PILER-CR	1689502-1689527	26	NZ_CP022762	Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence	874406-874431	4	0.846
NZ_CP016442_1	1.2\|1689502\|26\|NZ_CP016442\|PILER-CR	1689502-1689527	26	NZ_CP023017	Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence	946681-946706	4	0.846
NZ_CP016442_1	1.2\|1689502\|26\|NZ_CP016442\|PILER-CR	1689502-1689527	26	NZ_CP014703	Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence	873521-873546	4	0.846
NZ_CP016442_1	1.2\|1689502\|26\|NZ_CP016442\|PILER-CR	1689502-1689527	26	NZ_CP022771	Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence	874398-874423	4	0.846
NZ_CP016442_1	1.2\|1689502\|26\|NZ_CP016442\|PILER-CR	1689502-1689527	26	NZ_CP022777	Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence	874416-874441	4	0.846
NZ_CP016442_1	1.2\|1689502\|26\|NZ_CP016442\|PILER-CR	1689502-1689527	26	NZ_CP022799	Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence	874390-874415	4	0.846
NZ_CP016442_1	1.2\|1689502\|26\|NZ_CP016442\|PILER-CR	1689502-1689527	26	NZ_CP022764	Ralstonia solanacearum strain T82 plasmid unnamed, complete sequence	978079-978104	4	0.846
NZ_CP016442_1	1.2\|1689502\|26\|NZ_CP016442\|PILER-CR	1689502-1689527	26	NZ_CP022797	Ralstonia solanacearum strain SL2312 plasmid unnamed, complete sequence	978076-978101	4	0.846
NZ_CP016442_1	1.2\|1689502\|26\|NZ_CP016442\|PILER-CR	1689502-1689527	26	NZ_CP022758	Ralstonia solanacearum strain T101 plasmid unnamed, complete sequence	978060-978085	4	0.846
NZ_CP016442_1	1.2\|1689502\|26\|NZ_CP016442\|PILER-CR	1689502-1689527	26	NC_009444	Pseudomonas fluorescens SBW25 plasmid pQBR103, complete sequence	171898-171923	5	0.808
NZ_CP016442_2	2.1\|1823001\|45\|NZ_CP016442\|CRISPRCasFinder	1823001-1823045	45	NC_020548	Azoarcus sp. KH32C plasmid pAZKH, complete sequence	423473-423517	5	0.889
NZ_CP016442_2	2.1\|1823001\|45\|NZ_CP016442\|CRISPRCasFinder	1823001-1823045	45	NZ_CP012748	Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence	450547-450591	6	0.867

1. spacer 1.2|1689502|26|NZ_CP016442|PILER-CR matches to NZ_CP022775 (Ralstonia solanacearum strain T12 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

tcgtgttgaccgcgttgctcagtgcg	CRISPR spacer
gcttgttgaccgcgttgcgcagcgcg	Protospacer
 * *************** ***.***

2. spacer 1.2|1689502|26|NZ_CP016442|PILER-CR matches to NZ_CP022762 (Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

tcgtgttgaccgcgttgctcagtgcg	CRISPR spacer
gcttgttgaccgcgttgcgcagcgcg	Protospacer
 * *************** ***.***

3. spacer 1.2|1689502|26|NZ_CP016442|PILER-CR matches to NZ_CP023017 (Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

tcgtgttgaccgcgttgctcagtgcg	CRISPR spacer
gcttgttgaccgcgttgcgcagcgcg	Protospacer
 * *************** ***.***

4. spacer 1.2|1689502|26|NZ_CP016442|PILER-CR matches to NZ_CP014703 (Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence) position: , mismatch: 4, identity: 0.846

tcgtgttgaccgcgttgctcagtgcg	CRISPR spacer
gcttgttgaccgcgttgcgcagcgcg	Protospacer
 * *************** ***.***

5. spacer 1.2|1689502|26|NZ_CP016442|PILER-CR matches to NZ_CP022771 (Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

tcgtgttgaccgcgttgctcagtgcg	CRISPR spacer
gcttgttgaccgcgttgcgcagcgcg	Protospacer
 * *************** ***.***

6. spacer 1.2|1689502|26|NZ_CP016442|PILER-CR matches to NZ_CP022777 (Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

tcgtgttgaccgcgttgctcagtgcg	CRISPR spacer
gcttgttgaccgcgttgcgcagcgcg	Protospacer
 * *************** ***.***

7. spacer 1.2|1689502|26|NZ_CP016442|PILER-CR matches to NZ_CP022799 (Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

tcgtgttgaccgcgttgctcagtgcg	CRISPR spacer
gcttgttgaccgcgttgcgcagcgcg	Protospacer
 * *************** ***.***

8. spacer 1.2|1689502|26|NZ_CP016442|PILER-CR matches to NZ_CP022764 (Ralstonia solanacearum strain T82 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

tcgtgttgaccgcgttgctcagtgcg	CRISPR spacer
gcttgttgaccgcgttgcgcagcgcg	Protospacer
 * *************** ***.***

9. spacer 1.2|1689502|26|NZ_CP016442|PILER-CR matches to NZ_CP022797 (Ralstonia solanacearum strain SL2312 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

tcgtgttgaccgcgttgctcagtgcg	CRISPR spacer
gcttgttgaccgcgttgcgcagcgcg	Protospacer
 * *************** ***.***

10. spacer 1.2|1689502|26|NZ_CP016442|PILER-CR matches to NZ_CP022758 (Ralstonia solanacearum strain T101 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.846

tcgtgttgaccgcgttgctcagtgcg	CRISPR spacer
gcttgttgaccgcgttgcgcagcgcg	Protospacer
 * *************** ***.***

11. spacer 1.2|1689502|26|NZ_CP016442|PILER-CR matches to NC_009444 (Pseudomonas fluorescens SBW25 plasmid pQBR103, complete sequence) position: , mismatch: 5, identity: 0.808

tcgtgttgaccgcgttgctcagtgcg	CRISPR spacer
cccagttgaccgagttgctcagtgct	Protospacer
.*  ******** ************

12. spacer 2.1|1823001|45|NZ_CP016442|CRISPRCasFinder matches to NC_020548 (Azoarcus sp. KH32C plasmid pAZKH, complete sequence) position: , mismatch: 5, identity: 0.889

ccccgcgggggcagcgaacgaagtgagcgtgggggtcgtttcatc	CRISPR spacer
ccctcggggggcagcgagcgaagcgagcgtgggggtcgtttcatc	Protospacer
***.  ***********.*****.*********************

13. spacer 2.1|1823001|45|NZ_CP016442|CRISPRCasFinder matches to NZ_CP012748 (Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.867

ccccgcgggggcagcgaacgaagtgagcgtgggggtcgtttcatc	CRISPR spacer
ccctcggggggcagcgaacgcagtgagcgtgggggttgtttcatt	Protospacer
***.  ************** ***************.*******.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1474425 : 1482706

Yaba_monkey_tumor_virus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_069745879.1\|1474425_1475346_+	alpha/beta hydrolase	Q6TUZ7	Yaba_monkey_tumor_virus	5.1e-17	27.2
WP_006486840.1\|1475365_1476289_-	histone deacetylase family protein	A0A2K9KZC4	Tupanvirus	8.7e-41	34.6
WP_083281816.1\|1476332_1477676_+	lytic murein transglycosylase B	NA	NA	NA	NA
WP_069745881.1\|1477743_1478646_-	cysteine synthase CysM	A0A1X9I5F1	Streptococcus_phage	3.7e-52	40.5
WP_069745882.1\|1478857_1479217_-	competence protein ComE	NA	NA	NA	NA
WP_069745883.1\|1479291_1480284_-	ADP-glyceromanno-heptose 6-epimerase	R9S880	Prochlorococcus_phage	4.8e-29	31.5
WP_069745884.1\|1480347_1481298_-	D-glycero-beta-D-manno-heptose-7-phosphate kinase	A0A2H4N7X4	Lake_Baikal_phage	4.9e-15	26.8
WP_069745885.1\|1481305_1482706_-	UDP-glucose/GDP-mannose dehydrogenase family protein	A0A127AXI2	Bacillus_phage	1.4e-77	38.3

DBSCAN-SWA_2

1565217 : 1575690

Bacillus_virus(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_069745945.1\|1565217_1566519_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	7.3e-94	51.4
WP_069745946.1\|1566766_1567033_+	DUF2164 domain-containing protein	NA	NA	NA	NA
WP_069745947.1\|1567073_1568384_-	replication-associated recombination protein A	G3MBE0	Bacillus_virus	6.1e-80	40.2
WP_069745948.1\|1568551_1569241_-	outer membrane lipoprotein chaperone LolA	NA	NA	NA	NA
WP_069745949.1\|1569287_1571597_-	DNA translocase FtsK	G1FGP1	Mycobacterium_phage	1.4e-84	50.0
WP_069745950.1\|1571991_1572954_+	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	3.2e-62	43.6
WP_069745951.1\|1573082_1573862_+	DNA mismatch repair protein MutS	A0A0P0IDT4	Acinetobacter_phage	8.5e-13	31.4
WP_069745952.1\|1573848_1574472_+	trimeric intracellular cation channel family protein	NA	NA	NA	NA
WP_069745953.1\|1574571_1575690_-	sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC	G9BWD6	Planktothrix_phage	9.0e-24	35.0

DBSCAN-SWA_3

1811842 : 1820935

unidentified_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_069746128.1\|1811842_1813378_+	polynucleotide adenylyltransferase PcnB	H7BUW3	unidentified_phage	1.8e-22	30.7
WP_069746129.1\|1813413_1813956_+	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	NA	NA	NA	NA
WP_069746130.1\|1813952_1814639_+	deoxynucleoside kinase	A0A0M3UL55	Enterococcus_phage	4.7e-07	29.9
WP_069746131.1\|1814682_1815498_+	3-methyl-2-oxobutanoate hydroxymethyltransferase	A0A0N7HVJ8	Ostreococcus_lucimarinus_virus	3.6e-38	34.6
WP_069746132.1\|1815643_1817575_-	bifunctional anthranilate synthase component I family protein/class IV aminotransferase	S4VT78	Pandoravirus	2.1e-57	37.2
WP_069746133.1\|1817579_1818716_-	molecular chaperone DnaJ	E3T4P7	Cafeteria_roenbergensis_virus	3.1e-24	39.5
WP_069746134.1\|1818982_1820935_-	molecular chaperone DnaK	A0A1V0SH73	Hokovirus	1.3e-147	49.4

DBSCAN-SWA_4

2261356 : 2302119

Acidithiobacillus_phage(18.18%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011875599.1\|2261356_2262913_+\|transposase	IS21-like element IS408 family transposase	K4I413	Acidithiobacillus_phage	1.4e-160	55.1
WP_006397350.1\|2262929_2263679_+	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	4.8e-82	60.7
WP_011516097.1\|2264062_2264287_+	TomA0	NA	NA	NA	NA
WP_011516096.1\|2264374_2265370_+	phenol hydroxylase	NA	NA	NA	NA
WP_011516095.1\|2265409_2265679_+	monooxygenase	NA	NA	NA	NA
WP_011516094.1\|2265701_2267261_+	YHS domain-containing protein	NA	NA	NA	NA
WP_011516093.1\|2267257_2267614_+	phenol hydroxylase	NA	NA	NA	NA
WP_069746426.1\|2267692_2268757_+	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_035486348.1\|2268759_2269116_+	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_021159336.1\|2269133_2270078_+	catechol 2,3-dioxygenase	NA	NA	NA	NA
WP_011516089.1\|2270099_2270549_+	heme-binding protein	NA	NA	NA	NA
WP_021159335.1\|2270615_2272127_+	2-hydroxymuconic semialdehyde dehydrogenase	NA	NA	NA	NA
WP_042974940.1\|2272129_2272912_+	2-oxopent-4-enoate hydratase	NA	NA	NA	NA
WP_035486339.1\|2272990_2273902_+	acetaldehyde dehydrogenase (acetylating)	E5EQ71	Micromonas_sp._RCC1109_virus	3.5e-34	35.1
WP_021159332.1\|2273921_2274968_+	4-hydroxy-2-oxovalerate aldolase	E5EQ69	Micromonas_sp._RCC1109_virus	6.0e-46	35.0
WP_021159331.1\|2274964_2275753_+	2-oxo-3-hexenedioate decarboxylase	NA	NA	NA	NA
WP_011516083.1\|2275764_2275956_+	4-oxalocrotonate tautomerase family protein	NA	NA	NA	NA
WP_069746427.1\|2276015_2277518_+	YHS domain-containing protein	NA	NA	NA	NA
WP_021159329.1\|2277586_2277853_+	Toluene-4-monooxygenase subunit TmoB	NA	NA	NA	NA
WP_011516080.1\|2277908_2278244_+	Rieske 2Fe-2S domain-containing protein	NA	NA	NA	NA
WP_035480072.1\|2278284_2278599_+	monooxygenase	NA	NA	NA	NA
WP_011516078.1\|2278653_2279640_+	Toluene-4-monooxygenase system protein E	NA	NA	NA	NA
WP_083281847.1\|2279739_2280321_+	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_094067478.1\|2280349_2281467_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	9.5e-50	40.8
WP_083281848.1\|2281508_2282000_+	hypothetical protein	NA	NA	NA	NA
WP_069746428.1\|2282065_2282671_+	glutathione transferase GstA	NA	NA	NA	NA
WP_156814768.1\|2282741_2283559_-\|transposase	IS5-like element ISRme6 family transposase	NA	NA	NA	NA
WP_011516074.1\|2283728_2284790_+	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_049799775.1\|2284934_2286263_+	aromatic hydrocarbon degradation protein	NA	NA	NA	NA
WP_011516071.1\|2286998_2287829_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_066132413.1\|2289939_2290701_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_069746429.1\|2290725_2290953_+	hypothetical protein	W6JKT0	Anomala_cuprea_entomopoxvirus	9.3e-05	39.2
WP_027813734.1\|2291405_2291750_+	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZDM8	Stx2-converting_phage	1.2e-40	72.0
WP_027813733.1\|2291789_2293382_+\|transposase	IS66 family transposase	A0A0P0ZEB3	Stx2-converting_phage	1.5e-144	53.9
WP_021161685.1\|2293657_2293825_+	hypothetical protein	NA	NA	NA	NA
WP_012213993.1\|2297327_2298116_+	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	8.8e-34	34.1
WP_010792188.1\|2298454_2298658_+	DUF2892 domain-containing protein	NA	NA	NA	NA
WP_011516037.1\|2298665_2300075_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_011516036.1\|2300074_2300941_+	TIGR00730 family Rossman fold protein	A0A1D8KU27	Synechococcus_phage	2.3e-11	32.4
WP_021161690.1\|2301108_2302119_+\|transposase	IS21-like element ISRme20 family transposase	A0A2L1IVA1	Escherichia_phage	6.3e-85	49.4

DBSCAN-SWA_5

2549591 : 2589919

Burkholderia_phage(40.0%)

integrase,plate,transposase,protease

attL 2548420:2548436|attR 2554365:2554381

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2548420:2548436	attL	NA	NA	NA	NA
WP_069746574.1\|2549591_2550113_+\|protease	ClpXP protease specificity-enhancing factor	A0A1S5R3H3	Pseudomonas_phage	9.6e-21	52.0
WP_069746575.1\|2550382_2551600_+\|integrase	tyrosine-type recombinase/integrase	Q7M297	Enterobacteria_phage	3.0e-89	43.0
WP_069746576.1\|2552214_2555067_-	DUF927 domain-containing protein	A0A1B0VP75	Pseudomonas_phage	6.6e-71	35.6
2554365:2554381	attR	NA	NA	NA	NA
WP_069746577.1\|2555194_2555521_-	hypothetical protein	NA	NA	NA	NA
WP_069746578.1\|2555530_2555878_-	hypothetical protein	NA	NA	NA	NA
WP_006765346.1\|2555870_2556083_-	hypothetical protein	NA	NA	NA	NA
WP_069746579.1\|2556075_2556378_-	hypothetical protein	NA	NA	NA	NA
WP_156814772.1\|2556370_2556547_-	hypothetical protein	NA	NA	NA	NA
WP_069746580.1\|2556907_2557186_-	hypothetical protein	NA	NA	NA	NA
WP_083281855.1\|2557182_2557404_-	AlpA family phage regulatory protein	E5E3Y1	Burkholderia_phage	7.9e-09	55.8
WP_156814773.1\|2558510_2559662_-	hypothetical protein	NA	NA	NA	NA
WP_069746581.1\|2560182_2560758_+	recombinase family protein	A0A219Y9V9	Aeromonas_phage	9.3e-25	40.7
WP_006412423.1\|2561125_2562118_-\|transposase	IS5-like element ISBmu2 family transposase	E5E3P6	Burkholderia_phage	5.3e-161	85.5
WP_069746582.1\|2562193_2562439_-	hypothetical protein	NA	NA	NA	NA
WP_156814774.1\|2562826_2563447_-	hypothetical protein	NA	NA	NA	NA
WP_069746584.1\|2563900_2564635_-	response regulator transcription factor	NA	NA	NA	NA
WP_083281856.1\|2564636_2565722_-	histidine kinase	NA	NA	NA	NA
WP_069746585.1\|2566140_2566683_+	hypothetical protein	NA	NA	NA	NA
WP_069747673.1\|2567031_2567235_+	hypothetical protein	NA	NA	NA	NA
WP_069746586.1\|2567295_2568096_-	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_069746587.1\|2568417_2571597_+	type VI secretion system tip protein VgrG	A0A2H4JCD4	uncultured_Caudovirales_phage	3.9e-56	28.4
WP_167362197.1\|2571634_2576239_+	RHS repeat protein	A0A2H4JFP5	uncultured_Caudovirales_phage	1.1e-46	49.5
WP_006412423.1\|2576276_2577269_-\|transposase	IS5-like element ISBmu2 family transposase	E5E3P6	Burkholderia_phage	5.3e-161	85.5
WP_069746588.1\|2577502_2577856_+	hypothetical protein	NA	NA	NA	NA
WP_069746589.1\|2578418_2578847_+	hypothetical protein	NA	NA	NA	NA
WP_156814775.1\|2578859_2579201_+	hypothetical protein	NA	NA	NA	NA
WP_069746591.1\|2579368_2579692_+	hypothetical protein	NA	NA	NA	NA
WP_156814776.1\|2579796_2580234_+	SMI1/KNR4 family protein	NA	NA	NA	NA
WP_069746593.1\|2580624_2581107_+	DUF4265 domain-containing protein	NA	NA	NA	NA
WP_069747674.1\|2581213_2581582_+	hypothetical protein	NA	NA	NA	NA
WP_069746594.1\|2581663_2582446_-	DotU family type IV/VI secretion system protein	NA	NA	NA	NA
WP_006412423.1\|2583991_2584984_-\|transposase	IS5-like element ISBmu2 family transposase	E5E3P6	Burkholderia_phage	5.3e-161	85.5
WP_069746595.1\|2585104_2585716_-	type VI secretion system lipoprotein TssJ	NA	NA	NA	NA
WP_069746596.1\|2586090_2586729_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_027788514.1\|2586773_2587289_+	type VI secretion system contractile sheath small subunit	NA	NA	NA	NA
WP_069746597.1\|2587304_2588795_+	type VI secretion system contractile sheath large subunit	NA	NA	NA	NA
WP_006477093.1\|2588867_2589371_+	type VI secretion system tube protein Hcp	NA	NA	NA	NA
WP_006477092.1\|2589433_2589919_+\|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA

DBSCAN-SWA_6

3620959 : 3665970

uncultured_Caudovirales_phage(34.48%)

capsid,tail,terminase,head,plate,holin,protease,integrase,portal

attL 3617870:3617887|attR 3657678:3657695

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
3617870:3617887	attL	NA	NA	NA	NA
WP_069747349.1\|3620959_3621463_+\|protease	serine protease inhibitor ecotin	NA	NA	NA	NA
WP_069747350.1\|3621499_3622114_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_069747351.1\|3622229_3622970_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_069747352.1\|3623109_3623448_-	hypothetical protein	NA	NA	NA	NA
WP_083281886.1\|3624143_3625295_+	right-handed parallel beta-helix repeat-containing protein	NA	NA	NA	NA
WP_049036486.1\|3626075_3627173_+\|integrase	site-specific integrase	A0A2D1GMX8	Marinobacter_phage	2.0e-44	31.3
WP_063776540.1\|3627187_3628066_-	DNA adenine methylase	B7SYF3	Stenotrophomonas_phage	3.0e-06	23.8
WP_156814798.1\|3628107_3629568_-	hypothetical protein	NA	NA	NA	NA
WP_049036481.1\|3629647_3629878_-	hypothetical protein	NA	NA	NA	NA
WP_049036479.1\|3629874_3630252_-	hypothetical protein	NA	NA	NA	NA
WP_069747354.1\|3630244_3630604_-	hypothetical protein	NA	NA	NA	NA
WP_069747355.1\|3630705_3632004_-	pyridoxal phosphate biosynthetic protein PdxJ	NA	NA	NA	NA
WP_069747356.1\|3632003_3632366_-	beta-hexosaminidase	NA	NA	NA	NA
WP_049036614.1\|3632415_3632628_-	hypothetical protein	NA	NA	NA	NA
WP_034196549.1\|3632865_3633507_-	LexA family transcriptional regulator	A0A1I9KG86	Aeromonas_phage	9.7e-31	38.7
WP_072465517.1\|3633601_3633871_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_049098129.1\|3633954_3634497_+	hypothetical protein	C7BGG0	Burkholderia_phage	6.9e-30	46.8
WP_049098132.1\|3634483_3634867_+	hypothetical protein	NA	NA	NA	NA
WP_069747358.1\|3635127_3637635_+	virulence protein E	A0A2D1GN57	Marinobacter_phage	4.0e-96	40.9
WP_069747359.1\|3637857_3638631_+	hypothetical protein	NA	NA	NA	NA
WP_160313263.1\|3638981_3640064_+	hypothetical protein	NA	NA	NA	NA
WP_049098403.1\|3640868_3642980_+\|terminase	phage terminase large subunit family protein	A0A2D1GMT1	Marinobacter_phage	9.2e-179	53.4
WP_006497114.1\|3642993_3643200_+	hypothetical protein	NA	NA	NA	NA
WP_069747360.1\|3643196_3644690_+\|portal	phage portal protein	A0A2H4JFL5	uncultured_Caudovirales_phage	6.8e-136	51.6
WP_069747361.1\|3644686_3645751_+\|protease	Clp protease ClpP	A0A2H4JDI2	uncultured_Caudovirales_phage	1.8e-45	36.0
WP_049098395.1\|3645781_3646126_+\|head	head decoration protein	NA	NA	NA	NA
WP_069747362.1\|3646199_3647195_+\|capsid	major capsid protein	A0A2H4J890	uncultured_Caudovirales_phage	4.3e-102	56.4
WP_034188730.1\|3647196_3647484_+	hypothetical protein	NA	NA	NA	NA
WP_049035129.1\|3647486_3648017_+\|tail	phage tail protein	A0A2H4JBV1	uncultured_Caudovirales_phage	7.0e-11	30.5
WP_049098350.1\|3648006_3648531_+	hypothetical protein	Q75QM3	Wolbachia_phage	1.1e-24	41.2
WP_049117405.1\|3648534_3649215_+\|plate	phage baseplate assembly protein V	A0A1B2LRU5	Wolbachia_phage	3.8e-17	28.5
WP_049117406.1\|3649274_3649475_+	hypothetical protein	NA	NA	NA	NA
WP_034195754.1\|3649474_3649810_+\|plate	phage baseplate protein	A0A2H4JA09	uncultured_Caudovirales_phage	3.9e-23	48.1
WP_069747363.1\|3649806_3650703_+\|plate	baseplate J protein	A0A218M4K5	Erwinia_phage	3.0e-46	41.0
WP_069747364.1\|3650692_3651271_+\|tail	phage tail protein I	Q6QI98	Burkholderia_phage	8.7e-31	45.4
WP_049036049.1\|3651258_3653256_+\|tail	tail fiber protein	E5E3V2	Burkholderia_phage	1.5e-106	50.5
WP_049036047.1\|3653271_3654051_+\|tail	tail fiber assembly protein	E5E3Q6	Burkholderia_phage	2.1e-56	57.1
WP_069747365.1\|3654134_3655304_+\|tail	phage tail sheath family protein	A0A2H4J869	uncultured_Caudovirales_phage	3.5e-156	71.1
WP_027787026.1\|3655314_3655818_+\|tail	phage major tail tube protein	Q7M2A5	Pseudomonas_phage	2.1e-44	54.3
WP_059497706.1\|3655915_3656218_+\|tail	phage tail assembly protein	A0A1B2LRV6	Wolbachia_phage	2.7e-07	39.0
WP_069747366.1\|3656298_3658740_+\|tail	phage tail tape measure protein	A0A2H4JG00	uncultured_Caudovirales_phage	1.3e-56	37.9
3657678:3657695	attR	NA	NA	NA	NA
WP_049035112.1\|3658750_3659629_+\|tail	phage tail protein	A0A2H4J875	uncultured_Caudovirales_phage	5.2e-35	37.5
WP_049035111.1\|3659603_3659810_+\|tail	phage tail protein	A0A2H4J9Z9	uncultured_Caudovirales_phage	1.2e-14	56.7
WP_049035109.1\|3659819_3660869_+	phage late control D protein	A0A2H4JBF6	uncultured_Caudovirales_phage	9.4e-84	48.1
WP_034188712.1\|3660945_3661230_+\|holin	holin	C7BGD7	Burkholderia_phage	5.6e-39	93.6
WP_049117464.1\|3661232_3661727_+	glycoside hydrolase family 104 protein	Q6J1Q5	Burkholderia_virus	7.6e-76	86.0
WP_080982996.1\|3661723_3662218_+	DUF2514 family protein	C7BGD9	Burkholderia_phage	5.7e-39	58.9
WP_027787034.1\|3662388_3663174_+	DNA adenine methylase	Q8W6S4	Burkholderia_virus	9.7e-134	83.2
WP_080983000.1\|3663394_3663778_+	PAAR domain-containing protein	NA	NA	NA	NA
WP_049098666.1\|3663784_3664282_+	DUF4123 domain-containing protein	NA	NA	NA	NA
WP_081052677.1\|3664271_3664742_+	hypothetical protein	NA	NA	NA	NA
WP_083281888.1\|3664629_3665241_+	hypothetical protein	NA	NA	NA	NA
WP_080983001.1\|3665646_3665970_+	hypothetical protein	A4PE26	Ralstonia_virus	2.3e-17	48.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP016444

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP016442

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection