CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NZ_CP012887	Mycobacterium chimaera strain AH16 plasmid unnamed2, complete sequence	0 crisprs	NA	0	0	0
NZ_CP012885	Mycobacterium chimaera strain AH16 chromosome, complete genome	9 crisprs	DEDDh,cas3,csa3,DinG,RT,cas4,WYL,c2c9_V-U4	1	2	7
NZ_CP012886	Mycobacterium chimaera strain AH16 plasmid unnamed1, complete sequence	0 crisprs	csf1gr8,csf4gr11,csf2gr7,csf3gr5,Cas9_archaeal,DEDDh,c2c9_V-U4	0	0	4
NZ_CP012888	Mycobacterium chimaera strain AH16 plasmid unnamed3, complete sequence	0 crisprs	NA	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP012885_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012885_1

368058-368146

Orphan

Consensus_repeat	Method
CCCTGGGGACCCGGCCCCGGCGG	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP012885_1

>merge|NZ_CP012885|1|368058-368146|CRISPRCasFinder
CCCTGGGGGCCCGGCCCCGGCGGCCCCGGTTTGATCGTTCCGATGCCCCCGGGCGGCCCGGGCGGGCCCGGCGGTCCCGTCTCCGGCCC

>NZ_CP012885|1|1|368058-368146|CRISPRCasFinder
CCCTGGGGGCCCGGCCCCGGCGG	CCCCGGTTTGATCGTTCCGATGCCCCCGGGCGGCCCGGGCGGG
CCCGGCGGTCCCGTCTCCGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012885.2\|WP_042910501.1\|359016_360246_-\|Mur-ligase-family-protein	unknown	unknown	gnl\|CDD\|223840
NZ_CP012885.2\|WP_008263260.1\|363570_364836_+\|aspartate-kinase	unknown	unknown	gnl\|CDD\|235843
NZ_CP012885.2\|WP_020821423.1\|369134_370436_+\|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA	unknown	unknown	gnl\|CDD\|274583
NZ_CP012885.2\|WP_042910508.1\|368298_368955_+\|sensor-domain-containing-protein	unknown	unknown	gnl\|CDD\|372884
NZ_CP012885.2\|WP_172417484.1\|376840_378397_+\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|234594
NZ_CP012885.2\|WP_042910502.1\|360356_361349_+\|DEDDh-family-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|180377
NZ_CP012885.2\|WP_161807779.1\|366032_367034_+\|DUF4185-domain-containing-protein	unknown	unknown	gnl\|CDD\|379383
NZ_CP012885.2\|WP_072501140.1\|358316_359024_-\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NZ_CP012885.2\|WP_042910513.1\|374571_375252_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP012885.2\|WP_042910516.1\|378429_379149_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP012885.2\|WP_042910509.1\|370432_371746_+\|ergothioneine-biosynthesis-protein-EgtB	unknown	unknown	gnl\|CDD\|274581
NZ_CP012885.2\|WP_008263265.1\|367155_367581_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368014
NZ_CP012885.2\|WP_042910514.1\|375262_376735_-\|glutamate--cysteine-ligase	unknown	unknown	unknown
NZ_CP012885.2\|WP_042910505.1\|364836_365895_+\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NZ_CP012885.2\|WP_072501477.1\|361365_363285_-\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|235154
NZ_CP012885.2\|WP_020821414.1\|357881_358304_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_008263246.1\|357263_357875_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_CP012885.2\|WP_042910510.1\|371745_372456_+\|ergothioneine-biosynthesis-protein-EgtC	unknown	unknown	gnl\|CDD\|132483
NZ_CP012885.2\|WP_042910512.1\|373417_374575_+\|ergothioneine-biosynthesis-PLP-dependent-enzyme-EgtE	unknown	unknown	gnl\|CDD\|275139
NZ_CP012885.2\|WP_042910511.1\|372455_373421_+\|L-histidine-N(alpha)-methyltransferase	unknown	unknown	gnl\|CDD\|226751

Protein	Function_ID	Function_description	E-value
NZ_CP012885.2\|WP_042910501.1\|359016_360246_-\|Mur-ligase-family-protein	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	9.11159e-80
NZ_CP012885.2\|WP_008263260.1\|363570_364836_+\|aspartate-kinase	gnl\|CDD\|235843	PRK06635, PRK06635, aspartate kinase; Reviewed.	0
NZ_CP012885.2\|WP_020821423.1\|369134_370436_+\|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA	gnl\|CDD\|274583	TIGR03444, EgtA_Cys_ligase, ergothioneine biosynthesis glutamate--cysteine ligase EgtA. Members of this bacterial protein family, EgtA, resemble the glutamate--cysteine ligase of the two-step pathway for glutathione (GSH) biosynthesis, but instead are involved in the biosynthesis of the histidine-derived thiol, ergothioneine (EGT). Successful in vitro reconstitution of EGT biosynthesis using EgtBCDE and gamma-L-glutamyl-L-cysteine suggests that this enzyme is a bone fide glutamate--cysteine ligase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	1.99075e-164
NZ_CP012885.2\|WP_042910508.1\|368298_368955_+\|sensor-domain-containing-protein	gnl\|CDD\|372884	pfam14032, PknH_C, PknH-like extracellular domain. This domain is functionally uncharacterized. It is found as the periplasmic domain of the bacterial protein kinase PknH. The domain is also found in isolation in numerous proteins, for example the lipoproteins lpqQ, lprH, lppH and lpqA from M. tuberculosis. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 268 amino acids in length. There are two completely conserved C residues that are likely to form a disulphide bond. A second pair of cysteines are less well conserved probably form a second disulphide bond. It seems likely that this domain functions to bind some as yet unknown ligand.	2.33066e-36
NZ_CP012885.2\|WP_172417484.1\|376840_378397_+\|glycerol-kinase-GlpK	gnl\|CDD\|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NZ_CP012885.2\|WP_042910502.1\|360356_361349_+\|DEDDh-family-exonuclease	gnl\|CDD\|180377	PRK06063, PRK06063, DEDDh family exonuclease.	0
NZ_CP012885.2\|WP_161807779.1\|366032_367034_+\|DUF4185-domain-containing-protein	gnl\|CDD\|379383	pfam13810, DUF4185, Domain of unknown function (DUF4185).	2.0628e-55
NZ_CP012885.2\|WP_072501140.1\|358316_359024_-\|glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	1.54603e-112
NZ_CP012885.2\|WP_042910513.1\|374571_375252_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.24924e-19
NZ_CP012885.2\|WP_042910516.1\|378429_379149_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.02272e-23
NZ_CP012885.2\|WP_042910509.1\|370432_371746_+\|ergothioneine-biosynthesis-protein-EgtB	gnl\|CDD\|274581	TIGR03440, egtB_TIGR03440, ergothioneine biosynthesis protein EgtB. Members of this family include EgtB, and enzyme of the ergothioneine biosynthesis, as found in numerous Actinobacteria. Characterized homologs to this family include a formylglycine-generating enzyme that serves as a maturase for an aerobic sulfatase (cf. the radical SAM enzymes that serve as anaerobic sulfatase maturases). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	7.71579e-154
NZ_CP012885.2\|WP_008263265.1\|367155_367581_+\|hypothetical-protein	gnl\|CDD\|368014	pfam04592, SelP_N, Selenoprotein P, N terminal region. SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma. It is thought to be glycosylated. SelP may have antioxidant properties. It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function. The N-terminal region of SelP can exist independently of the C terminal region. Zebrafish selenoprotein Pb lacks the C terminal Sec-rich region, and a protein encoded by the rat SelP gene and lacking this region has also been reported. N-terminal region contains a conserved SecxxCys motif, which is similar to the CysxxCys found in thioredoxins. It is speculated that the N terminal region may adopt a thioredoxin fold and catalyze redox reactions. The N-terminal region also contains a His-rich region, which is thought to mediate heparin binding. Binding to heparan proteoglycans could account for the membrane binding properties of SelP. The function of the bacterial members of this family is uncharacterized.	1.36838e-05
NZ_CP012885.2\|WP_042910505.1\|364836_365895_+\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NZ_CP012885.2\|WP_072501477.1\|361365_363285_-\|2-isopropylmalate-synthase	gnl\|CDD\|235154	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated.	0
NZ_CP012885.2\|WP_042910510.1\|371745_372456_+\|ergothioneine-biosynthesis-protein-EgtC	gnl\|CDD\|132483	TIGR03442, TIGR03442, ergothioneine biosynthesis protein EgtC. Members of this strictly bacterial protein family show similarity to class II glutamine amidotransferases (see pfam00310). They are distinguished by appearing in a genome context with, and usually adjacent to or between, members of families TIGR03438 (an uncharacterized methyltransferase) and TIGR03440 (an uncharacterized protein). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	1.45493e-109
NZ_CP012885.2\|WP_008263246.1\|357263_357875_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	8.42319e-112
NZ_CP012885.2\|WP_042910512.1\|373417_374575_+\|ergothioneine-biosynthesis-PLP-dependent-enzyme-EgtE	gnl\|CDD\|275139	TIGR04343, pyridoxal-phosphate-dependent_transferase, ergothioneine biosynthesis PLP-dependent enzyme EgtE. Members of this protein family are the pyridoxal phosphate-dependent enzyme EgtE, which catalyzes the final step in the biosynthesis of ergothioneine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	7.90528e-170
NZ_CP012885.2\|WP_042910511.1\|372455_373421_+\|L-histidine-N(alpha)-methyltransferase	gnl\|CDD\|226751	COG4301, COG4301, Uncharacterized conserved protein [Function unknown].	6.72733e-161

>NZ_CP012885.2|WP_008263265.1|367155_367581_+|hypothetical-protein
MRTSTATAPAAAAAAYRAPRVFQLAAWVAIVAGIVFIVAVIFFTGFILGHRGGHHGHHHHKHHHHAMLHHRGPGGPGGPGGGTQGGPGAPTGPGATTAPASPSPVRPSGMAPGQLPASIFHSAAASHAAPGQAPSVIVLTN
>NZ_CP012885.2|WP_161807779.1|366032_367034_+|DUF4185-domain-containing-protein
MLRIGPTAGTGTPTGDYGIGATDLCEFVEFPTELLQVCGDSFAGQGVGFGGWYAPVALHVDTASVDDPAGVRYTGVTGIAHPLLADPAPPDSSQLPAGVVQVNRRNYLMVTTTKDLEPQSSRLVTAEPARAGWQTIPGSKRPASYQGGSQTQISGYYDPIPTPESPSGWVYIVADSFTRRDPVVLYRATPQTFTDRSRWQGWAAGASGGWGKPPTPLWPDAVGEMCIRQIDGKAVLSYFNAATGNMEVRVAADPTALGDAPVTTVVQHDEWPEPAESLPPPYDNRLAQPYGGYISPGSTLDELRIFVSQWDTRARVAAPYRVIQFAVNPFKPE
>NZ_CP012885.2|WP_042910505.1|364836_365895_+|aspartate-semialdehyde-dehydrogenase
MVAIGVVGATGQVGQVMRRLLDERDFPALNSGGSVRFFASARSQGRKLEFRGQEIEVEDAATADPSGLDIALFSAGKTMSLVQAPRFAAAGVTVIDNSSAWRKDPDVPLVVSEVNFTRDVANRARSLKKGIIANPNCTTMAAMPVLKVLHDEAGLQRLVVSSYQAVSGSGIAGVQELSTQARAVVDDAEQLVQDGGAVQFPAPKTYVAPIAFNVVPLAGSLVDDGSGETDEDQKLRHESRKILGIPDLAVSGTCVRVPVFTGHSLSINAEFARPLSPQRARELLDGAPGVKVVDVPTPLAAAGVDESLVGRIRQDPGVPDGRGLALFVSGDNLRKGAALNTIQIAELLAAEL
>NZ_CP012885.2|WP_008263260.1|363570_364836_+|aspartate-kinase
MALVVQKYGGSSVANADRIRRVAERIVATKKQGNDVVVVVSAMGDTTDDLMDLAQQVCPAPPPRELDMLLTAGERISNALVAMAIESLGAQARSFTGSQAGVITTGTHGNAKIIDVTPGRLQAALDEGRVVLVAGFQGVSQDTRDVTTLGRGGSDTTAVALAAALRADVCEIYTDVDGIFSADPRIVHNARKLDTVTFEEMLEMAACGAKVLMLRCVEYARRYNIPVHVRSSYSENPGTVVVGSIKDIAMEDPILTGVAHDRSEAKVTVVGIPDIPGYAARVFRALADADVNIDMVLQNVSKVEDGKTDITFTCSRDSGPTAVAKLDALKDEIGFSQLLYDDHVGKVSLIGAGMRSHPGVTATFCESLAEVGVNIELISTSEIRISVLCRDTELDKAVVALHEAFGLGGEESATVYAGTGR
>NZ_CP012885.2|WP_072501477.1|361365_363285_-|2-isopropylmalate-synthase
MTVTSNSDAFSSTRSIVKPAGPRGPGQPAWNPQRGSSMPVSRYRPFAEEVEPIRLADRTWPDRVITSAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIITGGAIPDDVTIQVLTQCRPELIERTFEACLGAPQAIVHFYNSTSILQRRVVFRAEKAAVQDIATAGARKCVEEAAKYPGTRWRFEYSPESYTGTELEYAKQVCDAVGEIISPTPENPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKVDADAADTDVEDMLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKSDHGLALPRRLQIEFSQVVQKISEGEGGEVSPKEMWDAFSEEYLAPVWPLERVKQRVDASEEDSGVTSIAATVRINGVETEISGSGNGPLAAFVHALGDVGFDVAVLDYSEHAMSSGDDAQAAAYVEASVSIASAAEPGEAGLHPSGPVSIASAAEPGEAGRHPSGPVNGRTVWGVGIAPSITTASLRAVVSAVNRAARA
>NZ_CP012885.2|WP_042910502.1|360356_361349_+|DEDDh-family-exonuclease
MSAVCWGRPASEPDAGWAVIDVETSGFRPGQARIISLAVLGLDADGEVEQSVVSLLNPGVDPGPTHVHGLTAAMLEDQPQFADIASDVIDVLRGRTLVAHNVAFDYAFLAAEAELADIELPVDSVMCTVELARRLDLGVDNLRLETLAAHWSVTQERPHDAFDDAMVLTGVLASALKLARDGDVWLPVHPVTRRRWPNGRVTHDELRPLKVLASRMPCPYLNPGPYVGGRPLVQGMRVALAAEVGRTHEELVERILHAGLAYSEAVDRETSLVVCNDPAPEQGKGYLARKLGVPVISDATFMDCVRAVIGGTSMDEFTDTTNSDPQLALF
>NZ_CP012885.2|WP_042910501.1|359016_360246_-|Mur-ligase-family-protein
MVTTRARLALAAGASARWASRVTGRGAGAMIGGLIAMTLDRSVLRQLAAGRRTVVVTGTNGKSTTTRMTSAALATLGPVATNAEGANMDAGLVAALAANRRASLAALEVDEMHVPHVSDAVEPSVVVLLNLSRDQLDRVGEINVIERTLRAGLARHPNAVVVANCDDVLMTSAAYDSPNVVWVAAGGSWSNDSVSCPRSGEVIVRERGHWFSTGADFKRPSPQWWFDDRTLHGPDGLSLPMRLTLPGAVNRGNAAQAVAAAVALGADPAKAVAAVSAVDEVAGRYRTVRVGDHEVRMLLAKNPAGWQEALSMVDKRAAGVVISVNGQVPDGEDLSWLWDVRFEHFEQTEVVAAGERGTDLAVRLGYAGVEHTLVHDTVAAIASCPPGRVEVVANYTAFLQLQRALARRG
>NZ_CP012885.2|WP_072501140.1|358316_359024_-|glutamine-amidotransferase
MADSTVRIGLVLPDVMGTYGDGGNALVLRQRLLLRGIPAEIVEITLADPVPESLDLYTLGGAEDYAQRLATRHLVKHPGLQRAAQRGAPVLAICAAVQVLGHWYETSAGQRVDGVGMLDATTSPQAARTIGELATRPLLAGLTERLTGFENHRGGTVLGPSASPLGAVVKGAGNRSGDGFDGVVQGSVIATYMHGPCLARNPQLADLLLGSVVGELPPLPMLRRDLLRRERLAAR
>NZ_CP012885.2|WP_020821414.1|357881_358304_-|hypothetical-protein
MMKIRPRLAAGAALVAAFVASSAPSHASPEVLNGRYNVLYADNDKPTAWLFVPCGSDCTLATSQDGGTFVISWEFHLADGRWTHSGTSQAPCPNGASAPVTVNYSFDAVSLAGEGQQTTTDACGPEAGRTFTRSFQLSKA
>NZ_CP012885.2|WP_008263246.1|357263_357875_+|recombination-protein-RecR
MFEGPVQDLIDELGKLPGIGPKSAQRIAFHLLSVEPPDIDRLTAVLAKVRDGVRFCAVCGNVSDNERCRICADPRRDGSQVCVVEEPKDVQAVERTREFRGRYHVLGGALDPLSGVGPDQLRIRELLSRIGERVDDVDITEVIIATDPNTEGEATATYLVRMLRDIPGLTVTRIASGLPMGGDLEFADELTLGRALAGRRAMV
>NZ_CP012885.2|WP_042910508.1|368298_368955_+|sensor-domain-containing-protein
MTMRATHRAVLTVGFAVAGIVAPAVAAAHPSEPGVVNYAVLGKGSVGNIVGGPMGWESVFTQPGQGPWVDLPECNNWADIGLSEVYDDPDLASFNGAVTQTSANDQTHLVKQAVGVFATPDAAARAFHRVVDRTVGCSGQTTAIHLDNGSTQVWSFDGGPAGPADENWTKQEAGTDRRCFDQTRLRENVLLQAKVCQSGNAGPAVNVLAGAMQNALGQ
>NZ_CP012885.2|WP_020821423.1|369134_370436_+|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA
MTFAPITAAAPRSTGADPAPELKIAELTDSTAVAQYIADGCLVDAPLGRVGLELEAHCHDPAAPHRRPGWDEIAAVLDGLPALPGGSRITVEPGGAVELSGPPADGVLPAIEAMRRDQAVLQPAFAEAGLGLVFLGADPLRPPQRINPGARYRAMEKFFATSRSGEAGAAMMTSTASIQVNVDAGPREGWAARVRLAHALGPTMIAITANSPMLGGDFTGWVSSRQRVWGQMDSARCGPILGASGDDPGTDWGRYALKAPVMLVHTPGAEAVTQWVPFADWVDGRVLLGDRRPSVADLEYHLTTLFPPVRPRQWLEIRYLDSVPDALWPAVVFTLVALLDDPTAADAAAEAVAPVATAWDIAARLGLRDRRLYAAANACVAIAAERAPAELGDAMQRLVGLVEQGRCPGDDFADRVIEHGVAAEVSRAARGGL
>NZ_CP012885.2|WP_042910509.1|370432_371746_+|ergothioneine-biosynthesis-protein-EgtB
MTVTSCRETLADQLTRTRARTLRLVDFDDAELCRQYDPLMSPLVWDLAHIGQQEELWLLRGGDPGRPSMLSPAVEGLYDAFVHSRASRVDLPLLSPDEARAYCRTVRSAVFDALDALPDDPPGDEAAFAYAMVVSHENQHDETMLQALNLRSGPPLLCGTSMLPPARPGLAGTSVLVPGGEFVLGVDPATEPFSLDNERPGHVVDLPAFRIGRVPVTNGEWRHFIDDGGYDQPRWWSERGWRHRQAAGLTAPQFWNPDAATRTRFGHVEDIPADEPVQHVSYFEAEAYAAWAGARLPTEMEWEKACAWDPSAGARRRYPWGAQEPCEALANLGGAALRPAPVGAYPAGASAYGAEQMLGDVWEWTSSPLRPWPGFVPMLYERYSQPFFDGDYRVLRGGSWAVEPGILRPSFRNWDHPYRRQIFSGVRLAWDVPKEIA
>NZ_CP012885.2|WP_042910510.1|371745_372456_+|ergothioneine-biosynthesis-protein-EgtC
MCRHLGWLGADVTVSSLVLDPPFGLRVQAYAPRRQKHCLLNADGWGVGFFDAASDGAAPRRWRSQLPLWGDVSFESVAPALRSHCVVAAVRSATVGMPIEVSATAPFTDGQWLLSHNGIVDRAVLPATSQAESVCDSAMLAAVIFERGLDALGDTIAEIAAADPRARLNILAANGSRMLATAWGDTLSILRRPDGVVLASEPYDNDSDWEDVPDRHLVEVTAGEVTMTPLDHPKGP
>NZ_CP012885.2|WP_042910511.1|372455_373421_+|L-histidine-N(alpha)-methyltransferase
MTLSLSNHLAADSAYHALRRDVFEGLQKTPKSLPPKWFYDAVGSDLFDQITRLPEYYPTRAEAEILRARAAEIASASEADTLVELGSGTSEKTRLLLDALRTRGSLRRFVPFDVDASILSTAAAAIAQEYSGVEIKAVCGDFEEHLTEIPADGRRLFVFLGSTIGNLTPGPRADFLAALSAQMRPGDSLLLGTDLVKDLERLVRAYDDSAGVTAAFNRNVLAVVNRELDADFDVDAFAHVARWNPAEERIEMWLRADRGQRVRVGALELIVDFEAGEEMLTEVSCKFRPEKVSAELAAVGLRRTQWWTDGAGDFGLSLAVK
>NZ_CP012885.2|WP_042910512.1|373417_374575_+|ergothioneine-biosynthesis-PLP-dependent-enzyme-EgtE
MTAGDSLADRWRAARPPMAGLHLDNAACSRQSVAVIDAAAQHARNESEVGGYVAAEAAAPVLDAGRVAFAALTGMTDAEVVFTTGSLHALDLLLGAWPTKHRTVACLPGEYGPNLAVMAAHGFDRRLLPTMDDGRVALDDAARALDTDRPDLVHLTAVASHSGVVQPVSMIAQLCRELGLPLVVDAAQALGQVDCAAGADATYSSSRKWIAGPRGVGMLAVRRELMESLRPRLAAPQWARASGSPTVAQQLEFGEANVAARVGFSLALGEHLAYGPAAVRARLAALGGLNRTVLADVAGWAVVEEVEEPSAITTLAPTDGADPQAVRDWLLAERRILTTFVGVQRAPLELPGPLLRISPHLDTTAEDLETFAEALIAATAATATG
>NZ_CP012885.2|WP_042910513.1|374571_375252_-|class-I-SAM-dependent-methyltransferase
MSSDQVMDWDSAYREQAHFEGPPPWNIGEPQPELAALVAAGKFRSDVLDAGCGVAELSLSLAAQGYTVVGVDLTPTAVAAATKSAQERGLTTASFVQADITSLSGYDGRFATVVDSTLFHSLPVEGRDGYLRSVHRAAAPGASYFVLVFAKGAFPSEMEPKPNEVDEDELRAAVSKYWEIDEIRPSFILSNAVNIADAPFEFPPHDRDEQGRIKMPAYLLTAHKTG
>NZ_CP012885.2|WP_042910514.1|375262_376735_-|glutamate--cysteine-ligase
MGEEVKRTTYDSAHRREYRRKVQSCLNVFETMLAQSCFDSDQPLTGMEIECNLVDADYQPAMSNRHVLDAIGDPAYQTELGAYNIEFNVPPHALPGHTGLDLEAEVRASLNEAEIKAGAADGAHIVMIGILPTLMPEHLDHDWMSESTRYAALNDSIFTARGEDLPIDIDGPEPLNWHAATIAPESACTSMQLHLQLAPETFAANWNAAQIVAGPQLALGANSPFFFSHQLWAETRIELFTQSTDTRPEELKTQGVRPRVWFGEQWITSVLDLYRENIRYFPSLLPEVSEEDPVAELAAGRTPQLSELRLHNGTVYRWNRPVYDVVDGRPHLRLENRVLPAGPTVVDMLANSSFFYGMLRSLSEADSPLWDHLDFAVAEANFLAAARHGIDARLHWPGLGEVSARDLVLDTLLPMADDGLRRWGVDPEVRDRFLGVIEGRARAGRNGATWQVSTVRALQDAGMGRAAALAEMLRRYCEYMHANEPVHTWE
>NZ_CP012885.2|WP_172417484.1|376840_378397_+|glycerol-kinase-GlpK
MSELTGGGEQLAEFAEFVAAIDQGTTSTRCMIFDHEGAEVARHQLEHEQVLPQAGWVEHDPVEIWERTSSVLTSVLNRANLAPKNIAALGITNQRETTLVWNRKTGRPYYNAIVWQDTRTDRIASALEGDGRGEVIRRKAGLPPATYFSGAKLQWILENVDGVRDAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDVTNASRTMLMNLETLDWDDELLSFFAIPRAMLPRIGPSSSPQPYGVTAETGPAGGEIAITGVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGETIVRSDNGLLTTVCYQFGDAKPVYALEGSIAVTGAAVQWLRDQLGIISGAAQSEALARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAICYQSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWAGPADLRANWQEGRRWSPTWNDQQRAEGYAGWRKAVQRTLDWVSIT
>NZ_CP012885.2|WP_042910516.1|378429_379149_-|helix-turn-helix-transcriptional-regulator
MSNPFTPPEGPFGGRPGFGFGFGSGPVDRRALHEARRQARRDFREHLRDHAGGGHPGGYEGPFGFGPGFGPGFGPGFGFGPGGRRGAWRRGGPGRGKRGDVRAAILTLLSERPMHGYEMIQQIAERSNGLWKPSPGSVYPTLQLLDDEGLITASESAGSKKLFELTEQGRGAAEKIETPPWDEITEGADPGHMSLRAAVGQLFGAVGQSAHTASAEQQQRIVDILNNARREIYGILGED

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Crispr_ID: NZ_CP012885_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012885_2

1608887-1608965

Orphan

Consensus_repeat	Method
TCCGCCGCGGAGGTCCGTGGGCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012885_2

>merge|NZ_CP012885|2|1608887-1608965|CRISPRCasFinder
TCCGCCGCGGAGGTCCGTGGGCGCCGCTGCGCCTCATCGCTTCGCATTGCATCGTCCGCCGCGGAGGTCCGTGGCCGCC

>NZ_CP012885|2|2|1608887-1608965|CRISPRCasFinder
TCCGCCGCGGAGGTCCGTGGGCGCC	GCTGCGCCTCATCGCTTCGCATTGCATCG
TCCGCCGCGGAGGTCCGTGGCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012885.2\|WP_020821948.1\|1598087_1598618_+\|DUF3558-domain-containing-protein	unknown	unknown	gnl\|CDD\|378803
NZ_CP012885.2\|WP_009955270.1\|1609007_1609985_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP012885.2\|WP_008254755.1\|1614652_1615042_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319939
NZ_CP012885.2\|WP_020821960.1\|1615085_1615499_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NZ_CP012885.2\|WP_051445846.1\|1604475_1606110_-\|ABC-transporter-family-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173866
NZ_CP012885.2\|WP_051197806.1\|1607976_1608885_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP012885.2\|WP_020821956.1\|1610197_1610689_+\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|239474
NZ_CP012885.2\|WP_020821957.1\|1610767_1611157_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP012885.2\|WP_042911043.1\|1603244_1604489_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP012885.2\|WP_042911045.1\|1606144_1607980_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|182342
NZ_CP012885.2\|WP_020821961.1\|1616513_1617380_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|315987
NZ_CP012885.2\|WP_042911040.1\|1598712_1599216_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|224973
NZ_CP012885.2\|WP_042911042.1\|1600527_1603149_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|227061
NZ_CP012885.2\|WP_041320848.1\|1614149_1614635_+\|RrF2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|273242
NZ_CP012885.2\|WP_008254752.1\|1612249_1614091_+\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|180120
NZ_CP012885.2\|WP_008254722.1\|1597521_1598079_+\|DUF3558-domain-containing-protein	unknown	unknown	gnl\|CDD\|378803
NZ_CP012885.2\|WP_008254760.1\|1615565_1616444_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NZ_CP012885.2\|WP_042911041.1\|1599379_1600531_+\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|223497
NZ_CP012885.2\|WP_042911092.1\|1595573_1597340_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP012885.2\|WP_020821958.1\|1611320_1612250_+\|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl\|CDD\|235375

Protein	Function_ID	Function_description	E-value
NZ_CP012885.2\|WP_020821948.1\|1598087_1598618_+\|DUF3558-domain-containing-protein	gnl\|CDD\|378803	pfam12079, DUF3558, Protein of unknown function (DUF3558). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.	3.73752e-31
NZ_CP012885.2\|WP_009955270.1\|1609007_1609985_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.50326e-99
NZ_CP012885.2\|WP_008254755.1\|1614652_1615042_-\|VOC-family-protein	gnl\|CDD\|319939	cd08351, ChaP_like, ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins. ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	4.24427e-67
NZ_CP012885.2\|WP_020821960.1\|1615085_1615499_-\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	3.94653e-12
NZ_CP012885.2\|WP_051445846.1\|1604475_1606110_-\|ABC-transporter-family-substrate-binding-protein	gnl\|CDD\|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	8.69623e-158
NZ_CP012885.2\|WP_051197806.1\|1607976_1608885_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.7458e-85
NZ_CP012885.2\|WP_020821956.1\|1610197_1610689_+\|carbonic-anhydrase	gnl\|CDD\|239474	cd03379, beta_CA_cladeD, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	1.82269e-65
NZ_CP012885.2\|WP_020821957.1\|1610767_1611157_-\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	1.34296e-30
NZ_CP012885.2\|WP_042911043.1\|1603244_1604489_+\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	5.0976e-11
NZ_CP012885.2\|WP_042911045.1\|1606144_1607980_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|182342	PRK10261, PRK10261, glutathione transporter ATP-binding protein; Provisional.	7.51722e-170
NZ_CP012885.2\|WP_020821961.1\|1616513_1617380_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	0.00297791
NZ_CP012885.2\|WP_042911040.1\|1598712_1599216_-\|histidine-phosphatase-family-protein	gnl\|CDD\|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	3.15779e-45
NZ_CP012885.2\|WP_042911042.1\|1600527_1603149_+\|AAA-family-ATPase	gnl\|CDD\|227061	COG4717, COG4717, Uncharacterized conserved protein [Function unknown].	7.45274e-09
NZ_CP012885.2\|WP_041320848.1\|1614149_1614635_+\|RrF2-family-transcriptional-regulator	gnl\|CDD\|273242	TIGR00738, Putative_HTH-type_transcriptional_regulator, Rrf2 family protein. This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General].	1.50922e-49
NZ_CP012885.2\|WP_008254752.1\|1612249_1614091_+\|adenylyl-sulfate-kinase	gnl\|CDD\|180120	PRK05506, PRK05506, bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional.	0
NZ_CP012885.2\|WP_008254722.1\|1597521_1598079_+\|DUF3558-domain-containing-protein	gnl\|CDD\|378803	pfam12079, DUF3558, Protein of unknown function (DUF3558). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.	4.57725e-31
NZ_CP012885.2\|WP_008254760.1\|1615565_1616444_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	3.86964e-30
NZ_CP012885.2\|WP_042911041.1\|1599379_1600531_+\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	6.12647e-63
NZ_CP012885.2\|WP_042911092.1\|1595573_1597340_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.70912e-159
NZ_CP012885.2\|WP_020821958.1\|1611320_1612250_+\|sulfate-adenylyltransferase-subunit-CysD	gnl\|CDD\|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0

>NZ_CP012885.2|WP_051197806.1|1607976_1608885_-|ABC-transporter-permease
MDGAHGFSSHDAADFTSRRTLVLRRFARNRFAVASLTLLVLLFVGCYTLPAVLPFSYEDLDFTALLQPPSARHWLGTNALGQDLLAQILRGMQKSMLIGICVAVISTGIAATVGSVSGYFGGWRDRVLMWLVDLLLVVPSFILIAIVTPRTKDSANIVMLVLLLAGFGWMVSSRMVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVASAILAETGLSFLGFGIQPPDVSLGTLIANGTQSATTFPWVFLFPAGVLVLILVCANLTGDGLRDALDPGSTPVRGGAR
>NZ_CP012885.2|WP_042911045.1|1606144_1607980_-|ABC-transporter-ATP-binding-protein
MSPLLEVTDLAVTFATGGDPVTAVRGVSYRVEPGEVVAMVGESGSGKSVSAMAVVGLLPEYARVRGSVRLHDTELLGLDDDAMSRFRGKTVGMVFQDPMSALTPVYTVGDQIAEAIEIHQPRVGRRAARHRAVELLELVGIAQPERRARAFPHELSGGERQRVVIAIAIANDPDLLICDEPTTALDVTVQAQILEVLKTARDVTGAGVLIITHDLGVVAEFADRALVMYAGRVVESAEVHDLYRDRRMPYTVGLLGSVPRLDAAQGSRLVPIPGAPPSLAGLDPGCPFAPRCPLAIDECRLEEPELLPVGADHRAACIRTDQVGGRSAADIYGVSTTAVSARPDGSSVVVRVRDLTKTYRLTKGVLRRRAGEVRAVDGVSFELREGRTLGIVGESGSGKSTTLHEILELTGPQSGSIEVLGTDVTTLSSASRRSLRRDIQVVFQDPVASLDPRLPVFELLAEPLRANGFDKGRTNARVAELLEIVGLRRADAIRYPAEFSGGQKQRIGIARALALQPKILALDEPVSALDVSIQAGIINLLLDLQALFGLSYLFVSHDLSVIKHLAHEVVVMRSGTVVERGDSRQVFDNPQHEYTRQLLNAVPRPDPGARG
>NZ_CP012885.2|WP_051445846.1|1604475_1606110_-|ABC-transporter-family-substrate-binding-protein
MALALSGCSPAINLIPETGQNARIGTSSDINPRDPATLRDGGDLRLALTAFPPNFNILHIDGNSAEVAAMMKATLPRAFIIGPDGSTTVDTNYFTSIELTGTAPQVVTYTINPKAVWSDGTPITWEDIASQVHALSGADKNFEIAGPSGAERVASVTRGVDDRQAVMTFAKPYAEWRGMFAGNGMLLPKSMTATPEAFNKGQLDGPGPSAGPFIATSLDRTTLRIVLSRNPKWWGPRPRLDNITYLVLDDAARLPALQNNTIDATGVGTIDQLTIAQRTKGITIRRAPAPAWSHITFNGAPGSILADKALRVAVSRGIDRQTIAKVVQYGLTSDPVALGNHIYVAGQKGYQDNSAVVPYDPAAAKRELDALGWKQVGQFREKDGRPLIIRDLFYDAQGSRQFAQIAQHSLAQIGVKLELVARAGSGFFTNYINVGAFDLAQFGWLGDAFPLSSLTQIYKSDGESNFGKIGSPQIDAAIERTLEELDPDRARALANELDRLIWAEGFSLPLTQSPGDVAVRSTLANFGAAGLGDLDYTAIGFTRS
>NZ_CP012885.2|WP_042911043.1|1603244_1604489_+|alpha/beta-hydrolase
MTMNAKRSRVQQKLAELPGVRAVRRPISPHSADEFDLYYVRTGRKSRHPLVIIPGGPGVASVQMYKGLRRRAAAAGLDVIMIEHRGVGMSRHDDSGADLPPQSMTVNQVVDDVAAVLDDAHADSADIYGASYGTYIAAGVGVRHPERVHAMVLDSPLLSRHDIVIVRRAIRRLLLRGDSPETAALAPKMRKLVDAGVMTPAATHVVATIYGYGGADLLERQLDLLLQRRKLLWWTLSRFTTLSNLPFRYEEDLVSRIAFRELDYAAEPDGLPLDPAVAESEARTHRVTFEDEPYDLPTEMPNFNWPTAVISGGRDLITPPAVAERVASLLPDAVLLSLPSMAHSALDFREPVALAAADAVGRGDLKGLAAQASALDALPPRPEVRLLWKLIETAAAAEGALPVPTRLLRRLSCA
>NZ_CP012885.2|WP_042911042.1|1600527_1603149_+|AAA-family-ATPase
MKLHRLILTNYRGISHREIEFPDHGVVVVCGANEIGKSSMIEALDLLLESRDRSTKKEVKQVKPTHSDVGSEVSAEISCGPYRFVYRKRFHKRCETELTIITPCREQLTGDEAHERVRAMLAETVDSDLWHAQRVLQSTSTAAVDLSGCDALSRALDVAAGDSGGLCGTEPLLIERIDTEYARYFTPTGRPTGQWAAAIARLADAEAAVAECAAAVAEVDDRVARHAVLTEQVADFSQRRIAAGPRVAAAREAADRIAELTAQQREAQLVAAAAAATSAAATAAHTGRLQLLAEIDARAGAVAETEAQAHQAACAHASARAEAEACDATLQRATQVLADLQCRVDAARRGVDRLADLEEVDRLSTRLAKVDAIERDRERICAELSTIAVTEELLRRIEDACAAVDRIGDHLASTSAAIEFTAAADIHLVVGGERISLSAGQSWSITAAGSTVVEVSDVLTARVTPGATTLDIHAKHAAAQQEMTAALAAAEVADLAAARSADQRRRELVSTRDQLGATLAGLCGDEQIDEMRSRLARLRAQHPAEPAPGATDIGAARAELDVAQQGHAAASTDCEAHRQAATAAAAALAELSTRATVLQNTLEAQRAELQAAAGRLAAERASVSDEELAASADSALRAEQAADQRVGELAAALAAASPDAVAAELAEATKEAESLRERYEEAARALREITIELSVFGSEGRQGKLDTAETEREHAATEHSQIGARARAAKLLRSVMTRHRDTTRRRYVEPYRAELQRLGRPVFGPSFEVDIDSDLCIRSRTLNGITVPYESLSGGAKEQLGILARLAGAALVAKEDAVPVVVDDALGFTDPDRLAKMGQLFDSVGTHGQVIVLTCSPDRYDGVRGAHRIDLTA
>NZ_CP012885.2|WP_042911041.1|1599379_1600531_+|exonuclease-SbcCD-subunit-D
MRFLHTADWQLGMTRHFLAGDAQPRYSAARRDAVAGLGALAAEVDAEFVVVSGDVFEHNQLPPTVIGQSLEAMRAIGIPVYLLPGNHDPLDASSVYTSALFAAERPDNVVVLDRAGVHQVRPGLEIVAAPWRSKVPTTDLVADVLDGLPAAAGIRILVAHGGVDVLDPDKDKPSLIRLATLDDALSRGAVHYVALGDKHSLTQVGDSGRVWYSGSPEVTNFDDVESDPGHVLVVDVDETDPRGAVSVTARDVGRWRFVTLHRQVDTSRDIADLDVNLDLMTDKDRTVVRLALTGSLTVTDRAALDACLDKYARLFAWLGLWERHTDLAVIPADGEFSDLGIGGFAAAAVEELVATAREEDSATAVDAQAALALLLRLADRGAA
>NZ_CP012885.2|WP_042911040.1|1598712_1599216_-|histidine-phosphatase-family-protein
MTAERTLLLMRHAKSDYPAGVADHDRPLAPRGVRQAGLAGDWLRAHVPPVDRVLCSTATRTRETLRNTRIDAPVRYSERLYASTPGTLIDEINTVDDGIGTLLVIGHEPTMSALALGLGRAGGTDDAAAERISAKFPTSAIAVLAVPCAWKELELGGASLIDFVVPR
>NZ_CP012885.2|WP_020821948.1|1598087_1598618_+|DUF3558-domain-containing-protein
MRAAAVLLLAALLVLTGCSRSIGGNAVKAGGNVPRNNNSQQQYPNLLKECEVLTSDILAKTVGADPLDIQSTFVGAICRWQAANPAGLIDITRFWFEQGSLSNERKVAEFLKYKIESRPIAGIDSIVMRPDDANGACGVASDAAGVVGWWVNPQAPGIDACGQAIKLMELTLATNS
>NZ_CP012885.2|WP_008254722.1|1597521_1598079_+|DUF3558-domain-containing-protein
MRRSARALALVASALTILIPAVAACSDSGGNKPGATASSTPQKGQGNHGPMFPQCGGISDQTVAELTRVTGLINTARNSVGCQWLAGGGILGPHFSFSWYRGSPIGRERKTEELSRASVDDININGHGGFIAVGNEPNLGDSLCEVGIQFQDDFIEWSISFSQKPFPPPCDIAKELARQSIANSK
>NZ_CP012885.2|WP_042911092.1|1595573_1597340_-|ABC-transporter-ATP-binding-protein
MLLALLRQYIQPYRRLVAVLMVLQLISNLASLYLPTVNAAIIDEGVAKGDTAAIVRLGIVMLGATGLQVLCSVGAVYFGSRTGMGFGRDLRAAVFEHVLTFSERESARFGAPTLLTRSTNDVRQIQYLVQITATVLVTAPIMCLGGIVMALRQEAALTWLLLVSVPVMAVTNYWVMSHMLPLFRRMQGLIDGINRVMRDQLAGVRVVRAFAREGFERDRFARANAALSNTALTAGNWQALMLPVTTLTINVSSVALIWFGGLRIDRGQMQVGSLTAFLAYFTQILMAVLMATMTLVVLPRASVCAERITEVLTTRPAVTDPPGPASPPGKITGVVRLDGATFTYPGADRPVLQDISFIARPGTTTAIVGSTGSGKSTLISLICRLYDVTGGTVLVDDIDVRDYHTERLWSAIGLVPQRGYLFSGTIADNLRYGAAPGHDITGDEMWEALRVADADGFVRAHPDGLQMRVAQGGINFSGGQRQRLAIARAVIRRPAVYLFDDSFGALDVHTGARVRAALKPISKEATVIVVTQRVSTAAQADQVIVVDGGRLVGAGTHESLLADSATYAEFADSQAVGALPSGHVGGAQ
>NZ_CP012885.2|WP_009955270.1|1609007_1609985_-|ABC-transporter-permease
MTRFLARRLLNYVVLLALASFLTFCLTSVAFKPLDSLLQRNPRPPQAVIDAKAHALGLDEAIPIRYAHWASHAVRGDFGKTVTGQPVGESLWRRVGVTLRLLVIGSLVGTVAGIAAGAWGAIRQYRLSDRVVTMVALLVLSTPTFVIANLLILAALRVNWAVGLQIFDYTGETSPGVSGGAGAHFFDRLRHLVLPSLTLALAAAAGYSRYQRNAMLDVLGQDFIRTARAKGLTRRRALVKHGLRTALIPLATLFAYGVAGLVTGAVFVEKIFGWHGMGEWLVQGIATQDTNIVAAITVFSGAVVLLAGLLSDVFYAALDPRVRVS
>NZ_CP012885.2|WP_020821956.1|1610197_1610689_+|carbonic-anhydrase
MTVTDDLLANNAEYAKTFNGPLPMPPGKHVAVVACMDARLDVYRLLGLNEGEAHVIRNAGGVVTDDVIRSLAISQRLLGTREIILIHHTDCGMLTFTDDDFKRSIQEETGVKPPWAAEAFPDVAEDVRQSLRRIEGSPFVTKHVSARGFFFDVATGKLNEVTL
>NZ_CP012885.2|WP_020821957.1|1610767_1611157_-|PaaI-family-thioesterase
MIAQFLPQSPFVVKLGIVADRLEEDEVRLRLPWDPSNVTIGDMVHGGAIATLADLTVMAAAWCGVPAPPELRGVTVSMALDYMAPARATDVIGIGRVLRRGRSLVNCEAEIVDSGGTLVAKALATYKVG
>NZ_CP012885.2|WP_020821958.1|1611320_1612250_+|sulfate-adenylyltransferase-subunit-CysD
MTSDLKTAPAVGQYELSHLRSLEAEAIHIIREVAAEFERPVLLFSGGKDSIVMLHLALRAFRPGRLPFPVMHVDTGHNFDEVIATRDELVKEHGVRLVVASVQEDIDAGRVVEPRQGRNPIQTVTLLRAIRENKFDAAFGGARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEFDIWSYIGAENIALPSIYYAHRRKVFRRDGMLLAVDKNMQPNADEPVFEATVRFRTVGDVTCTGCVESQAATVEEVIAETAVSRLTERGATRADDRISEAGMEDRKRQGYF
>NZ_CP012885.2|WP_008254752.1|1612249_1614091_+|adenylyl-sulfate-kinase
MATLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWAAVEQTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIQHIVLAVNKMDLIGWDKEKFEAIRDEFHAFAARLDVHDVATIPISALHGDNVVTKSDQTPWYEGPALLSHLEEVYIAGDRNMVDVRFPVQYVIRPHTREHQDHRSYAGTVASGVMRAGDEVVVLPVGKHTRITAIEGPNGPVEEAFPPMAVSVTLADEIDISRGDLIARTHNQPRVAQEFDATVCWMADGAALEPGRDYVIKHTTRTTHAKVTALDYRLDVNTLHRDKSATALKLNELGRISLRTQVPLLLDEYTRNPSTGSFILIDPHTNGTVAAGMVLRDASAQAASPNTVRHKPSAIAQARPRGKTVWFTGLSGSGKSSVAMLVEQKLLEKGSLAYVLDGDNLRHGLNADLGFSMADRAENLRRLAHVAALLADCGNVVLVPAISPLAEQRELARKVHADAGFEFIEVFCDTPIDECEKRDPKGLYAKARAGEITQFTGIDSPYQPPANPDLRLTPDGTIEEQAQRVLDLLESRG
>NZ_CP012885.2|WP_041320848.1|1614149_1614635_+|RrF2-family-transcriptional-regulator
MRMSAKAEYAVRAMIQLATVPDGTLVKTDDLAQAQGIPPQFLVDILTNLRTDRLVRSHRGREGGYELARSGSDISIADVLRCIDGPLASVRDIGLGDLPYSGPTAALTDVWRALRASMRSVLEQTTLADVATGGLPKHVAQLADDYRKQESQRHGSARTGD
>NZ_CP012885.2|WP_008254755.1|1614652_1615042_-|VOC-family-protein
MSISFNHTIVASRDKRESAEFLTELFGLPSPKPFGHFMVVELEHGATLDYADAPDGADIPRQHYAFLVSEQEFDTIYDKIRARGMQHWADPGATRPGEINHNDGGRGVYFTDPSGHAMEILTRPYGSGG
>NZ_CP012885.2|WP_020821960.1|1615085_1615499_-|VOC-family-protein
MDFTSTSIAHVRLTVTDIERSRQFYESVFGWPVLLEVPDNADEATRNQLSFLFGGVIYDLGGTLLGLRPVAAGRFDENRVGLDHIAFRLTTRDELDSAAAHLDELGVAHEPIKDIGPSYILEFRDPDNIALELTAPK
>NZ_CP012885.2|WP_008254760.1|1615565_1616444_+|LLM-class-flavin-dependent-oxidoreductase
MTMPVMEPDLDATVLETWARTIDEGPFSSLCWGERIAFDNPDNLTLLGALAAWTDRVRLLTTVIVPQLHDPVMLAKGLATGDMLSGGRLTVGIGVGGRHEDYHAVGADPATQTMRGMAERVAVMKRVWAGEKTTDSVRPVGPAPVQPGGPPLFVGSIGPKTIRSAAAWADGLAGTTLDLDVAKQNELFDVTRDAWARAGKPKPHLITSFWFAFGSPEESRAQVHRHLRRYMNWIPAEYVDAMAPMTGWAGSEDELLDVLRRFEEIGTDEVQLIPTSSDVDQLRRAAEVAGRL
>NZ_CP012885.2|WP_020821961.1|1616513_1617380_+|tetratricopeptide-repeat-protein
MTQQELPAPLAEMTGLMARCANNGDFAGAALQANELVTLCRATLGERDPNVLELKVALATVQLRAGEDADVYADLDALIPDLVAVLGPDHLSTLTARHLFAGRQQPPVSSLSEWSQLVADEQRILGPDHESTLMARERVAEKRWETGDFAGAMTEGQHVLAARRRVLGDDHADTLGTRLMLAIWRGRAGDIPGAITELEWLIGELRDKLGSGHVHLLMARHMFTLWAPKRAGVTDGVTAWEALVEEEARVLGDEHPVTIAARQELAGWCARHRARAGEPDTPVDWSAS

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Crispr_ID: NZ_CP012885_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012885_3

2581954-2582067

Orphan

Consensus_repeat	Method
GGTGTGATCGCGGCTTCGCCGCTCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012885_3

>merge|NZ_CP012885|3|2581954-2582067|CRISPRCasFinder
GGTGTGATCGCGGCTTCGCCGCTCAACATGGTCCATCGGCTCGGGTGTGATCGCGGCTTCGCCGCTCAACATGGTCCATCGGCTCGGGTGTGATCGCGGCTTCGCCGCTCAACA

>NZ_CP012885|3|3|2581954-2582067|CRISPRCasFinder
GGTGTGATCGCGGCTTCGCCGCTCAACA	TGGTCCATCGGCTCGGGTGTGATCGCGGCTTCGCCGCTCAACATGGTCCATCGGCTCG
GGTGTGATCGCGGCTTCGCCGCTCAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012885.2\|WP_054585463.1\|2581156_2581831_-\|phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|224837
NZ_CP012885.2\|WP_054585465.1\|2587179_2587932_+\|MSMEG_4193-family-putative-phosphomutase	unknown	unknown	gnl\|CDD\|163560
NZ_CP012885.2\|WP_014384579.1\|2586802_2587105_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_054585459.1\|2574527_2575478_+\|cell-division-protein-FtsQ/DivIB	unknown	unknown	gnl\|CDD\|224505
NZ_CP012885.2\|WP_008256225.1\|2588591_2589380_+\|SCO1664-family-protein	unknown	unknown	gnl\|CDD\|274813
NZ_CP012885.2\|WP_014384578.1\|2585625_2586648_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235906
NZ_CP012885.2\|WP_003878110.1\|2579369_2579660_+\|YggT-family-protein	unknown	unknown	gnl\|CDD\|223833
NZ_CP012885.2\|WP_008256205.1\|2583729_2584260_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|224793
NZ_CP012885.2\|WP_054585461.1\|2578559_2579204_+\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|224712
NZ_CP012885.2\|WP_054585458.1\|2573049_2574531_+\|UDP-N-acetylmuramate--L-alanine-ligase	unknown	unknown	gnl\|CDD\|234757
NZ_CP012885.2\|WP_054585469.1\|2577716_2578493_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223402
NZ_CP012885.2\|WP_162494295.1\|2584262_2585327_-\|quinone-dependent-dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235388
NZ_CP012885.2\|WP_008256146.1\|2575744_2576902_+\|cell-division-protein-FtsZ	unknown	unknown	gnl\|CDD\|236468
NZ_CP012885.2\|WP_008256153.1\|2579923_2580721_+\|DivIVA-domain-containing-protein	unknown	unknown	gnl\|CDD\|226127
NZ_CP012885.2\|WP_008256210.1\|2585359_2585629_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_072501282.1\|2576964_2577711_+\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|224413
NZ_CP012885.2\|WP_008256203.1\|2582337_2583693_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|181163
NZ_CP012885.2\|WP_054585462.1\|2580814_2581153_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|376764
NZ_CP012885.2\|WP_085976493.1\|2589455_2590223_+\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	unknown	unknown	gnl\|CDD\|224139
NZ_CP012885.2\|WP_008256222.1\|2587993_2588581_+\|DUF3090-domain-containing-protein	unknown	unknown	gnl\|CDD\|213872

Protein	Function_ID	Function_description	E-value
NZ_CP012885.2\|WP_054585463.1\|2581156_2581831_-\|phosphoribosyltransferase	gnl\|CDD\|224837	COG1926, COG1926, Predicted phosphoribosyltransferases [General function prediction only].	7.58023e-93
NZ_CP012885.2\|WP_054585465.1\|2587179_2587932_+\|MSMEG_4193-family-putative-phosphomutase	gnl\|CDD\|163560	TIGR03848, MSMEG_4193, probable phosphomutase, MSMEG_4193 family. A three-gene system broadly conserved among the Actinobacteria includes MSMEG_4193 and homologs, a subgroup among the larger phosphoglycerate mutase family protein (pfam00300). Another member of the trio is a probable kinase, related to phosphatidylinositol kinases; that context supports the hypothesis that this protein acts as a phosphomutase.	9.41418e-122
NZ_CP012885.2\|WP_054585459.1\|2574527_2575478_+\|cell-division-protein-FtsQ/DivIB	gnl\|CDD\|224505	COG1589, FtsQ, Cell division septal protein [Cell envelope biogenesis, outer membrane].	1.98809e-51
NZ_CP012885.2\|WP_008256225.1\|2588591_2589380_+\|SCO1664-family-protein	gnl\|CDD\|274813	TIGR03843, Phosphatidylinositol_3-_and_4-kinase, conserved hypothetical protein. This model represents a protein family largely restricted to the Actinobacteria (high-GC Gram-positives), although it is also found in the Chloroflexi. Distant similarity to the phosphatidylinositol 3- and 4-kinase is suggested by the matching of some members to pfam00454.	2.09061e-125
NZ_CP012885.2\|WP_014384578.1\|2585625_2586648_-\|hypothetical-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	0.00934122
NZ_CP012885.2\|WP_003878110.1\|2579369_2579660_+\|YggT-family-protein	gnl\|CDD\|223833	COG0762, COG0762, Predicted integral membrane protein [Function unknown].	1.05966e-07
NZ_CP012885.2\|WP_008256205.1\|2583729_2584260_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|224793	COG1881, COG1881, Phospholipid-binding protein [General function prediction only].	5.12793e-60
NZ_CP012885.2\|WP_054585461.1\|2578559_2579204_+\|cell-division-protein-SepF	gnl\|CDD\|224712	COG1799, COG1799, Uncharacterized protein conserved in bacteria [Function unknown].	3.81459e-45
NZ_CP012885.2\|WP_054585458.1\|2573049_2574531_+\|UDP-N-acetylmuramate--L-alanine-ligase	gnl\|CDD\|234757	PRK00421, murC, UDP-N-acetylmuramate--L-alanine ligase; Provisional.	0
NZ_CP012885.2\|WP_054585469.1\|2577716_2578493_+\|YggS-family-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223402	COG0325, COG0325, Predicted enzyme with a TIM-barrel fold [General function prediction only].	3.06984e-80
NZ_CP012885.2\|WP_162494295.1\|2584262_2585327_-\|quinone-dependent-dihydroorotate-dehydrogenase	gnl\|CDD\|235388	PRK05286, PRK05286, quinone-dependent dihydroorotate dehydrogenase.	7.70251e-175
NZ_CP012885.2\|WP_008256146.1\|2575744_2576902_+\|cell-division-protein-FtsZ	gnl\|CDD\|236468	PRK09330, PRK09330, cell division protein FtsZ; Validated.	0
NZ_CP012885.2\|WP_008256153.1\|2579923_2580721_+\|DivIVA-domain-containing-protein	gnl\|CDD\|226127	COG3599, DivIVA, Cell division initiation protein [Cell division and chromosome partitioning].	5.87672e-33
NZ_CP012885.2\|WP_072501282.1\|2576964_2577711_+\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|224413	COG1496, yfiH, Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism].	6.6978e-96
NZ_CP012885.2\|WP_008256203.1\|2582337_2583693_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|181163	PRK07906, PRK07906, hypothetical protein; Provisional.	0
NZ_CP012885.2\|WP_054585462.1\|2580814_2581153_+\|phage-holin-family-protein	gnl\|CDD\|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	0.00355035
NZ_CP012885.2\|WP_085976493.1\|2589455_2590223_+\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	gnl\|CDD\|224139	COG1218, CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase [Inorganic ion transport and metabolism].	1.26252e-75
NZ_CP012885.2\|WP_008256222.1\|2587993_2588581_+\|DUF3090-domain-containing-protein	gnl\|CDD\|213872	TIGR03847, TIGR03847, conserved hypothetical protein. The conserved hypothetical protein described here occurs as part of the trio of uncharacterized proteins common in the Actinobacteria.	2.70755e-88

>NZ_CP012885.2|WP_054585463.1|2581156_2581831_-|phosphoribosyltransferase
MNRPNGFLRRTATRNFRDRREAGRALAEELTSYRGRDLLVFGLARGGVPVAWEIAAALGAPLDVFLVRKLGVPNWSELAMGALASGGGLVMNDDVVASLRVTDEQVREVIDSETTELLRREHAYRGDRPIADPRDRVVILADDGIATGASMLAAVRAVRAAGPESITVAVPVGPESACRDLAREADDVVCATMPPGFEAVGQVYDDFHQVSDDEVRELLATPTA
>NZ_CP012885.2|WP_054585462.1|2580814_2581153_+|phage-holin-family-protein
MLVIALVLALIGLVALVFAVVTSNELVAWLCIAASVVGVVLLILDALRERQHREPGGAEDQDADEARPDEDDYVDYPEEAAAEGEAEAVADGTEPTAESSVAAEGRGDESAK
>NZ_CP012885.2|WP_008256153.1|2579923_2580721_+|DivIVA-domain-containing-protein
MPLTPADVHNVAFSKPPIGKRGYNEDEVDAFLDLVEAELTRLIEENSDLRQRIEELDQELASGGGAAAPAAAAAPTQAIPVREPEPEPVKAAAAPAAAVNNEEQAMKAARVLSLAQDTADRLTSTAQAESEKMLSDARANADQILSEARSTAETTVAEARQRADAMLADAQTRSETQLRQAQEKADALQADAERKHSEIMGTINQQRTVLEGRLEQLRTFEREYRTRLKTYLESQLEELGQRGSAAPVDSSADAGGFDQFNRGNN
>NZ_CP012885.2|WP_003878110.1|2579369_2579660_+|YggT-family-protein
MVLFFQILGFALFIFWLLLIARVVVEFIRSFSRDWHPTGITVVVLEIIMSITDPPVKLLRRLIPQLTIGAVRFDLSIMVLLLVAFIGMQLAFGAAA
>NZ_CP012885.2|WP_054585461.1|2578559_2579204_+|cell-division-protein-SepF
MSTLHKVKAYFGMAPMDDYEDEYYDDRAPSRGFPRPRFDDGYGRYDGDDYDDPRREPADYPPPGGYRGGYAEEPRYGSVHPREFDRGERGGPRFGSWLRNSTRGALAMDPRRMAMMFEEGHPLSKITTLRPKDYSEARTIGERFRDGTPVIMDLVSMDNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADVDVSPEERRRIAETGFYAYQ
>NZ_CP012885.2|WP_054585469.1|2577716_2578493_+|YggS-family-pyridoxal-phosphate-dependent-enzyme
MAVEISNGGDRESELTHALAAVRSRLAAAAEAAGRNVAEIEVLPITKFFPATDVVTLSRLGCRAVGESRDQEATAKVAEVTRLLAAPERADVGNPRWHMVGHIQRNKARSVAGWAHTAHSVDSAHLVTALDRGVAAALAEGRRTDPMRIYVQVSLDGDESRGGVDISRPGAVDQMCDQVEGSTNLALAGLMAIPPLDSDPDEAFDRLQSEHRRVLESHRNAVGLSAGMSNDFEIAVKHGSTCVRVGTALLGRRRLPSP
>NZ_CP012885.2|WP_072501282.1|2576964_2577711_+|peptidoglycan-editing-factor-PgeF
MQPGGQRLPDTGHVSVRIRRVTTTRAGGVSKPPFDTFNLGDHVGDDPAAVAENRSRLAAGIGLRAGRMVWMNQVHGDRVEVVDGPREAAVDDTDALVTRTARLALAVVTADCVPVLMADARAGVAAAVHAGRVGAQRGVVARTVEAMLELGARPHDISALLGPAVSGLNYEVPAAMADEVEAALPGSRTTTGAGTPGLDLRAGIACQLQGLGVTAIDIDPRCTVGDPTLFSHRRDAPTGRLASLVWME
>NZ_CP012885.2|WP_008256146.1|2575744_2576902_+|cell-division-protein-FtsZ
MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMSDADVKLDVGRDSTRGLGAGADPEVGRRAAEDAKDEIEELLRGADMVFVTAGEGGGTGTGGAPVVASIARKLGALTVGVVTRPFSFEGKRRGNQAESGIAALRESCDTLIVIPNDRLLQMGDAAVSLMDAFRSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTALMGIGSARGEGRSLKAAEIAINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQDAAHQDANIIFGTVIDDSLGDEVRVTVIAAGFDATGPGRKPVIGGNADKEEKVGAHRIESAKAGKLTSTLFEPVDAVSVPVHTNGSTLNIGGDDDDVDVPPFMRR
>NZ_CP012885.2|WP_054585459.1|2574527_2575478_+|cell-division-protein-FtsQ/DivIB
MTQPPPEPTVGDQADNPVPDDAATEPLVTGAGDQAAADQTPDPAEVEGPRRRARRERAERRAAQARATAIEEARREAKRRATGRPVHEPKPVARGVVRGLKMLLVTILLVIVGVGLALVLYFTPAMSARNIVVIGTGAVTREEVLDAARVRPGTPLLQINTSQVADRVAAIRRVASARVQRQYPSALRITIVERVPVAVKDFPDGPHLFDRDGVDFATGPPPPALPYLDVADPGPNDPATKAALQVLTALRPEVSDQVGRVAAPSVASITLTLGDGRVVIWGTTDRTDEKAEKLSALLTQPGKVYDVSSPDLPTVK
>NZ_CP012885.2|WP_054585458.1|2573049_2574531_+|UDP-N-acetylmuramate--L-alanine-ligase
MTTEQLPPELQRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGIHALRARGAQITIGHDAASLDLLPGGATAVITTHAAIPKTNPELVEARRRGIPVILRPAVLAKLMNGRTTLMVTGTHGKTTTTSMLIVALQHCGRDPSFAVGGEMGEAGTNAHHGSGDCFVAEADESDGSLLEYTPNVAVVTNIETDHLDFYGSADAYVGVFDSFVDRLAPGGALVVCVDDPGAAALARRTAELGIRVLRYGSGASLSGEPLAATLLSWQQQGTEAVAQIQLAPDLDPEQHPRVMRLSVPGRHMALNAMGALLAALEIGAPADAVLDGLAGFEGVRRRFELVGTAGNGQPVRVFDDYAHHPTEIVATLAAVRTLLEQSGDGRSIAVFQPHLYSRTKAFAEEFGHALDAADEVFVLDVYGAREQPLAGVSGASVAEHVSVPVRYLPNFSAAAEQVAAVAGPGDVIVTMGAGDVTLLGPEIVTALRVRANRGAPGALR
>NZ_CP012885.2|WP_008256203.1|2582337_2583693_+|M20/M25/M40-family-metallo-hydrolase
MTIQSGATEEPTNPSDDVVEVVSKLIRFDTTNTGEPETTKGEAECAQWVAEQLAEVGYAPQYVESGAPGRGNVFVRLPGADPSRGGLLIHGHLDVVPAEPTEWSVHPFSGAVKDGFVWGRGAIDMKDMVGMMIVVARQLKRAGIVPPRDLVFAFIADEEHGGTFGAQWLVDNRPDLFDGVTEAIGEVGGFSLTVPRRDGGERRLYLIETAEKGLSWMRLTARGPAGHGSMVHDQNAVTAVAEAVARLGRHQFPLVLTDTVAQFLAAVSEETGLTFDTESGDLRGAVEKLGPMARMLKAVLHDTANPTMLKAGYKANVVPAIAEAVVDCRILPGRKEAFEAEIDELLGPDVTREWIKDFSSYQTSFDGDLVDAMNAAVLALDPDARTVPYMLSGGTDAKSFARLGIRCFGFSPLRLPPDLDFTALFHGVDERVPIDALRFGTDVLTHFLTHC
>NZ_CP012885.2|WP_008256205.1|2583729_2584260_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MSTAPDPYASLPKLPTFTLTSQSVTDGQPLAKPQVSGIMGAGGEDVSPQLSWSGFPDGTRSFAVTVYDPDAPTASGFWHWAVANLPADVTELAEGAGDGSNLPGDALTLVNDAGLRRYLGAAPPAGHGPHRYYIAVHAVDTDKLDLPEDASPAFLGFNLFQHAIARAVIHATYEQK
>NZ_CP012885.2|WP_162494295.1|2584262_2585327_-|quinone-dependent-dihydroorotate-dehydrogenase
MYGLLRQLFFVIPPERIHTLVFGFLRGVTAVAWARRALRRLLGPTDPALASTVFGVRFPGPLGLAAGFDKDGLGVLTWGALGFGHAEVGTVTAHPQPGNPAPRLQQPRADRALLNRMGFNNLGAGALAMRLARQRPEVPIGVNIGKTKATPADQAVDDYRASARLVGPLASYLVVNVSSPNTPGLRDLQAVDSLRPILSAVLAETTTPVLVKIAPDLSDADVDAIADLAVELGLAGIVATNTTISRQGLRTPGVDELGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIENADDAWERITAGASLLQGYTGFIYGGGLWAKQIHDGVARRLHDGGFASLSEAVGAAARG
>NZ_CP012885.2|WP_008256210.1|2585359_2585629_-|hypothetical-protein
MTAARHSRLPAGWDTEMSDEYEWVPLRLPPEVTRVSASTRLSIEAEYRGWELTRVRLYNDGSRRVLLRRKKSRLDGTGYEGRRPDQPQL
>NZ_CP012885.2|WP_014384578.1|2585625_2586648_-|hypothetical-protein
MLSLAVLLGATVGCSSNPLAGAPRTIEPAAAAVSPPPSQSPAGAVRPLPAHAAAAVFDAGTRRLAVLAPGSDPAAPGSITVFGEAQAPPRVVDLPGPASALTDDGQGTAYLAARGGYFAVDLSTGHTAQVSVSDAAQTEFTAVARRADGRLVLGSADGAVYTLASPKPGAVSAASVASRNKVFARVDCLVTQGDTTVVLDRGQTSVTTIDADGHVQQALRAGRGATTMAADALGRVLVADTRGGQLLVYGVDPLILRQAYPVSQAPYGLAGSRALAWVSQTVSNIVIGYDLSTGIPVEKVRYPTVQQPNSLAFDEASDTLYVVSGSGAGVQVIDHAAGRR
>NZ_CP012885.2|WP_014384579.1|2586802_2587105_+|hypothetical-protein
MAVTADRHMTQEEFAVEDMSTGIFASGYGQVGDGRSFSFHIENRSLVVEVYRPRLAGPVPQADEVVATAVRSLVDIDLTDERSLSAAVRDSVAHAEPVSR
>NZ_CP012885.2|WP_054585465.1|2587179_2587932_+|MSMEG_4193-family-putative-phosphomutase
MTVILLRHGRSSSNTAGILAGRSEGVDLDDKGREQAAALIDRIGDLPIRELITSPLLRCRRTLEPLADALCLAPLVEDRLAEVDYGEWTGRKIGELVSEPLWKVVQAHPSAAVFPGGEGLAQVQARAVAAVREHDRRLASEHGGDALWVACTHGDVIKAVIADAYGIHLDGFQRVTADPASVSVIRYTELRPFVLHVNHTGARLSAALRAGPQPKEEATAETDGQPNGEAQAPPAAGVPSSDAVVGGSTD
>NZ_CP012885.2|WP_008256222.1|2587993_2588581_+|DUF3090-domain-containing-protein
MSRAIHVFRTPDRFVAGTVGQPGNRTFYIQAVHDARVVSVILEKQQVAVLAERIGALLLEVNRRFGTPVPPEPAEVEDLKPLITPVDAEFRVGTMGLGWDSEAQTVVVELLAVTDAEFDASVVLDDTEEGPDAVRVFLTPESARQFASRSNRVISAGRPPCPLCDEPLDPEGHICARANGYRRNALLGSDDDPEV
>NZ_CP012885.2|WP_008256225.1|2588591_2589380_+|SCO1664-family-protein
MLRNGELTVIGRIRSASNATFLCESTLDERAVHCVYKPVAGEAPLWDFPDGTLAGRERAAYLVSAQLGWNIVPYTIIRHGPAGPGMLQQWVQQPGDTVDTEPRPGPDLVDLFPAGKAQPGYLPVLRAYDYAGDEVVLMHADDIRLWRMAVFDVLVNNADRKGGHVLRDLDGHIFGVDHGVCLHVEDKLRTVLWGWAGKPIDSQTCKAVAGLAEALTGSFGDELAEHITSAEIAALRMRAHALLDNPVMPGPNRHRPIPWPAF
>NZ_CP012885.2|WP_085976493.1|2589455_2590223_+|3'(2'),5'-bisphosphate-nucleotidase-CysQ
MTDAALAADLAAEAGELLLKVRDEVGFGYPWALGDAGDSLANDLILRRLRVERPGDAVLSEEAYDDLSRLQHDRVWIIDPLDGTREFSTPGRDDWAVHIALWQRPSDGQREITDAAVSLPARGNIVYRSDTVTAGAARAGVTDTIRIAVSATRPPAVLHRMRQTLPIQPVAIGSAGAKAMAIIDGDVDAYVHAGGQWEWDSAAPAGVVMAAGMHASRLDGSPMRYNQLDPYLPDFVMCRAELAPILLGAIRDAWR

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Crispr_ID: NZ_CP012885_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012885_4

3644374-3644450

Orphan

Consensus_repeat	Method
GTAGTAACCACTTGGTTAGGTGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012885_4

>merge|NZ_CP012885|4|3644374-3644450|CRISPRCasFinder
GTAGTAACCACTTGGTTAGGTGACTGCCGGCGGCCCGCAGGGCCACCGGTGCCGGTAGTAACCACTTGGTTAGGTGA

>NZ_CP012885|4|4|3644374-3644450|CRISPRCasFinder
GTAGTAACCACTTGGTTAGGTGA	CTGCCGGCGGCCCGCAGGGCCACCGGTGCCG
GTAGTAACCACTTGGTTAGGTGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012885.2\|WP_054585391.1\|3650148_3651207_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|372616
NZ_CP012885.2\|WP_042912260.1\|3653434_3654751_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NZ_CP012885.2\|WP_139315447.1\|3635700_3636276_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_069953652.1\|3636759_3637341_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379402
NZ_CP012885.2\|WP_042912253.1\|3647575_3648127_+\|dTDP-4-dehydrorhamnose-3,5-epimerase-family-protein	unknown	unknown	gnl\|CDD\|380337
NZ_CP012885.2\|WP_051445807.1\|3632257_3635116_+\|RND-family-transporter	unknown	unknown	gnl\|CDD\|129913
NZ_CP012885.2\|WP_054585390.1\|3645729_3646503_+\|glucose-1-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|131672
NZ_CP012885.2\|WP_080691124.1\|3638531_3639716_-\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|380079
NZ_CP012885.2\|WP_072501355.1\|3646484_3647579_+\|CDP-glucose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|274236
NZ_CP012885.2\|WP_042912258.1\|3651206_3652034_-\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223528
NZ_CP012885.2\|WP_069953849.1\|3652406_3653057_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369777
NZ_CP012885.2\|WP_051445806.1\|3637562_3638081_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_145929536.1\|3645157_3645733_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379595
NZ_CP012885.2\|WP_080691223.1\|3649385_3650114_-\|cephalosporin-hydroxylase-family-protein	unknown	unknown	gnl\|CDD\|368223
NZ_CP012885.2\|WP_051445812.1\|3631340_3631658_+\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197385
NZ_CP012885.2\|WP_154074436.1\|3643623_3643776_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_054585745.1\|3638194_3638476_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_042912254.1\|3648123_3649347_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|378005
NZ_CP012885.2\|WP_051445808.1\|3630529_3631147_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|376526
NZ_CP012885.2\|WP_042910275.1\|3631829_3632261_+\|membrane-protein	unknown	unknown	gnl\|CDD\|283157

Protein	Function_ID	Function_description	E-value
NZ_CP012885.2\|WP_042912260.1\|3653434_3654751_+\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NZ_CP012885.2\|WP_069953652.1\|3636759_3637341_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379402	pfam13936, HTH_38, Helix-turn-helix domain. This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.	0.00150637
NZ_CP012885.2\|WP_080691124.1\|3638531_3639716_-\|L,D-transpeptidase-family-protein	gnl\|CDD\|380079	pfam17964, Big_10, Bacterial Ig domain. This entry represents a bacterial Ig-like domain found associated with transpeptidase domains.	5.14606e-66
NZ_CP012885.2\|WP_051445807.1\|3632257_3635116_+\|RND-family-transporter	gnl\|CDD\|129913	TIGR00833, Putative_membrane_protein_ActII-3, Transport protein. The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate].	0
NZ_CP012885.2\|WP_054585391.1\|3650148_3651207_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.70386e-14
NZ_CP012885.2\|WP_042912253.1\|3647575_3648127_+\|dTDP-4-dehydrorhamnose-3,5-epimerase-family-protein	gnl\|CDD\|380337	cd00438, cupin_RmlC, RmlC carbohydrate epimerase, involved in dTDP-L-rhamnose production. RmlC (deoxythymidine diphosphate (dTDP)-4-keto-6-deoxy-D-hexulose 3, 5-epimerase or dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; also known as RfbC) is a carbohydrate epimerase involved in the production of dTDP-L-rhamnose, a precursor of the bacterial cell wall constituent, L-rhamnose. L-Rhamnose (6-deoxy-l-mannose) plays an important role in the cell-wall structure of many bacterial species. It has been found to contribute to the virulence of several species, including the Gram-negative Salmonella enterica and Vibrio cholerae, where it is present as a part of the O-antigen, and is essential for the growth of Gram-positive bacteria such as Streptococcus pyogenes. RmlC converts dTDP-6-deoxy-D-xylo-4-hexulose to dTDP-6-deoxy-L-xylo-hexulose by catalyzing the epimerization of the 5-methyl and 3-hydroxyl groups of hexulose, the third of four steps in the dTDP-L-rhamnose biosynthetic pathway. RmlC belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	6.06697e-80
NZ_CP012885.2\|WP_072501355.1\|3646484_3647579_+\|CDP-glucose-4,6-dehydratase	gnl\|CDD\|274236	TIGR02622, CDP-glucose_46-dehydratase, CDP-glucose 4,6-dehydratase. Members of this protein family are CDP-glucose 4,6-dehydratase from a variety of Gram-negative and Gram-positive bacteria. Members typically are encoded next to a gene that encodes a glucose-1-phosphate cytidylyltransferase, which produces the substrate, CDP-D-glucose, used by this enzyme to produce CDP-4-keto-6-deoxyglucose. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	3.75684e-175
NZ_CP012885.2\|WP_042912258.1\|3651206_3652034_-\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	6.33371e-33
NZ_CP012885.2\|WP_069953849.1\|3652406_3653057_-\|hypothetical-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	0.00541564
NZ_CP012885.2\|WP_145929536.1\|3645157_3645733_+\|hypothetical-protein	gnl\|CDD\|379595	pfam14393, DUF4422, Domain of unknown function (DUF4422). This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 255 and 371 amino acids in length.	6.92459e-05
NZ_CP012885.2\|WP_080691223.1\|3649385_3650114_-\|cephalosporin-hydroxylase-family-protein	gnl\|CDD\|368223	pfam04989, CmcI, Cephalosporin hydroxylase. Members of this family are about 220 amino acids long. The CmcI protein is presumed to represent the cephalosporin-7--hydroxylase. However this has not been experimentally verified.	2.47642e-121
NZ_CP012885.2\|WP_051445812.1\|3631340_3631658_+\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|197385	cd10148, CsoR-like_DUF156, Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156. This superfamily includes various transcriptional regulators that respond to stressors including Cu(I), Ni(I), sulfite, and formaldehyde. It includes CsoR (copper-sensitive operon repressor) from Mycobacterium tuberculosis (MtCsoR), Bacillus subtilis (BsCsoR), Thermus thermophilus (TthCsoR), and Staphylococcus aureus (SaCsoR), Mycobacterium tuberculosis RicR (regulated in copper repressor, MtRicR), Escherichia coli RncR (formally known as YohL, nickel and cobalt-sensitive), Alcaligenes xylosoxidans NreA (nickel-sensitive), E. coli FrmR (formally known as YaiN, formaldehyde sensitive), and Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor, NWMN_0026.5, SaCstR). CsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis. For example, TthCsoR binds the promoter region of the copZ-csoR-copA operon, and represses expression of these genes, which encode the copper chaperone CopZ, CsoR, and the copper efflux P-type ATPase CopA, respectively. In the presence of excess Cu(I), TthCsoR binds this ion, and is released from the DNA, allowing expression of the downstream genes. TthCsoR also senses other metal ions such as Cu(II), Zn(II), Ag(I), Cd(II) and Ni(II). CsoRs form a homotetramer (dimer of dimers). In the case of MtCsoR, two Cys residues on opposite subunits within each dimer, along with a His residue, bind the Cu(I) ion. These residues are conserved in the majority of members of this superfamily. Exceptions include the functionally uncharacterized Bacillus subtilis YrkD where there is an Asn instead of His (C-N-C), E.coli RcnR where there is a Thr instead of the second Cys (C-H-T), or TthCsoR and E.coli FrmR where there is a His instead of the second Cys and which have an additional N-terminal His (not found in those family members having C-H-C) that may also be involved in metal binding (H-C-H-H). A conserved Tyr and a Glu residue facilitate allosteric regulation of DNA binding. SaCstR regulates genes predicted to function in sulfur metabolism; it is thought that oxidation of the intersubunit Cys pair to a mixture of disulphide and trisulphide linkages by sulfite, results in a reduced affinity of SaCstR for the operator DNA. SaCstR exists as a mixture of oligomeric states, including dimers, tetramers and octamers. The sequence of SaCstR was not available at the time this hierarchy was curated and therefore was not included. Escherichia coli RncR represses expression of the gene encoding the nickel and cobalt-efflux protein RcnA. The gene encoding Alcaligenes xylosoxidans NreA is part of the nre nickel resistance locus located on the pTOM9 plasmid from thisbacteria. Escherichia coli FrmR regulates the formaldehyde degradation frmRAB operon.	2.76066e-27
NZ_CP012885.2\|WP_054585390.1\|3645729_3646503_+\|glucose-1-phosphate-cytidylyltransferase	gnl\|CDD\|131672	TIGR02623, Glucose-1-phosphate_cytidylyltransferase, glucose-1-phosphate cytidylyltransferase. Members of this family are the enzyme glucose-1-phosphate cytidylyltransferase, also called CDP-glucose pyrophosphorylase, the product of the rfbF gene. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	1.98869e-171
NZ_CP012885.2\|WP_042910275.1\|3631829_3632261_+\|membrane-protein	gnl\|CDD\|283157	pfam05423, Mycobact_memb, Mycobacterium membrane protein. This family contains several membrane proteins from Mycobacterium species.	2.80629e-49
NZ_CP012885.2\|WP_042912254.1\|3648123_3649347_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|378005	pfam08484, Methyltransf_14, C-methyltransferase C-terminal domain. This domain is found in bacterial C-methyltransferase proteins. This domain is found C-terminal to methyltransferase domains such as pfam08241 or pfam08242. But this domain is not a methyltransferase.	2.48658e-81
NZ_CP012885.2\|WP_051445808.1\|3630529_3631147_-\|DsbA-family-protein	gnl\|CDD\|376526	pfam01323, DSBA, DSBA-like thioredoxin domain. This family contains a diverse set of proteins with a thioredoxin-like structure pfam00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyze one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways. This family also contains members with functions other than HCCA isomerisation, such as Kappa family GSTs, whose similarity to HCCA isomerases was not previously recognized. Some members have been annotated as dioxygenases, dehydrogenases, or putative glycerol-3-phosphate transfer proteins, but are most likely HCCA isomerase enzymes.	2.73179e-07

>NZ_CP012885.2|WP_154074436.1|3643623_3643776_+|hypothetical-protein
MDYETALTELLVRRAQLGSERVLDWLVYGTPLARLPRLDVVCGDHRAGPY
>NZ_CP012885.2|WP_080691124.1|3638531_3639716_-|L,D-transpeptidase-family-protein
MAVAVVVIGRGDDHNGALLTASVPRAEMPATVTVTPGPDAVNVDPLGAVTVSAVNGTLSDVRMVNDQDKPIPGVMAPDHLVWKLGGPLGYGRSYTLTVVSRGQTGTFASQMSSFTTLTPSTQASVSLTTTSGAALRDGGTYGVGTVIVAHFDEPIIDRAAAQRRLTVTTAPAVEGSWYWVDDHNAHWRPEHYYAAGTKITAAANIYGAPLGSGLYGQEDKQTSFTIGDAHVSIADDNTKQVNVYNNGVLVRTMPTSMGMGGTKTVAGQTLTFWTPPGVYTVMDKSNPVVMDSSTYGLPVSSHLGYRETINYATRISPDGIYLHQLDSTVWAQGNTDTSHGCLNLNGDNAKWFFDFSRSGDIVDVRDTGGPPQSLQNNGDWSVPWTQWQAGSALA
>NZ_CP012885.2|WP_054585745.1|3638194_3638476_-|hypothetical-protein
MAWLLADAAGPCLTGEQRTMVFVELGCGKNHLAIERILHVVVGKGFPLPTPLLAALTEWLNLYVGSPEERLLRDLTMQVRSLRPDFESGQCSD
>NZ_CP012885.2|WP_051445806.1|3637562_3638081_-|hypothetical-protein
MTVPGPPGQQGGDAPSVRQELVASFDHYLDAQRLVDQMSDDGFPVEHVRIIGDGVRTVEHVTGRMTTGKAALAGAGSGAWFGLLVGLLLSIFTAGPLWVWMLLVASIIGAFWGAAFGFIAHASTRGKRDFSSVQALEAQRYDVYVAAQYAAEAAARFVPGSRVDDSDAARTA
>NZ_CP012885.2|WP_069953652.1|3636759_3637341_+|helix-turn-helix-domain-containing-protein
MIIVATAESAEQALTAGTMRCPRGGCVGTLARWGYGRRRRIRGLEGAVIDARPRRVRCDGCGTTQILLPAALQPRRADTTEVIGIALARKATGLGHRRIAAALGRSPSTVRRWCRRARDCGHLNWLWQRGAQELIRLDADAFNQLTGTGNLLRDALAMLAAAAWWTRQRLGIAEPPWSLIGLYTRGHLLAPPG
>NZ_CP012885.2|WP_139315447.1|3635700_3636276_-|hypothetical-protein
MTGQPAAAHPTDKPGDRTPAVALDRRRQWVAAAVRIVFGVIWGIDAWLKWQPGFRATFLPNMIATAAAEPHWLAPWFDFVLRLERPAPAMGAYLGAAVETVIAITLIVGVARRAVYVAGAIYSLLVWTTAGGFGAPYPPGATDIGPSIIYAVVFCALLVMLEHGLGNRFALDDTLVRRLPWWSRLAGPPLR
>NZ_CP012885.2|WP_051445807.1|3632257_3635116_+|RND-family-transporter
MTAGNQTRPRLARFVRRFAVPIILAWLLVTVAVNVFWPPIESAARNHAVTMSPQDAPSMIASKQIGATFHEFDSDSVAMVVLESDTKLGEHAHRYYDGLVHELQGDHKHVQHVQNVWGSPLTAAGVQSRDGKAAYAQLNLAGNQGSTLGNESIKAVRVVLARTPPPAGMRVYLTGPAALTTDMNEAADKSMLTMMGVTGVVIMIMLFLTYRSVSTVLLVLAMVGLEMGTARGVVAILGNYDLLGFSTFVVAMLSSLAIAAGTDYAIFLIGRYQEARQAGEDAETAYYSMFRGTSHIILGSGLTIAGATLCLHLARLAYFRALGIPSALGLLIVVAGALTAAPAIVAVASRFGLLDPKRTVKVRGWRRIATATVRWPAPVLAASLALALVGIAIMPSMKTSYDDRNYIPADLPSNVGYTAAEHHFSTATMNPDILMVKSDHDMRNAGDMIILDRIAKEVFRTPGIAMVQSITRPLGGPVDHTSIPFQISAQSIPIRENLQFMKDRAADMLTMSDDLGAMIGSMKRMYGFVQQMSGATHHMVGDVNNMKATLDDIRDHLADFDDVARPVRSYLYWEPHCLNIPVCWATKSVFESIDGVDKFSENMRTLLGDVSNVDTLIPQMAQQFPPIISVATAMRASLQTMHSSFAGLVDQIVRMTDTASAMGQAFDASKSGDYFYLPPEAFENPDFQQGLKLFLSPDGHAARFIITHDTDPATPAGISAVTPELDAAHQAVKGSSLTDARFYLAGTAAVYRDIQAGSKYDLMIVGLAALTLIFAVMLIITRAAIASIAIVGTVLLSLGAAFGLSVLVWQHILGLELNWIAPVFGLIILLAVGSDYNLLLVSRFQEEIGAGLKTGIIRSMGSTGGVVTAAGLVFAFTMMSMAASDLSSIGQAGTTIGLGLLFDTLIVRSLMTPSIAALLGRWFWWPQQTAPRPTSQALHHARNGISTSGGSR
>NZ_CP012885.2|WP_042910275.1|3631829_3632261_+|membrane-protein
MLATLKRAWVPIVVVLVVLLGSIGVFKLRGVFGSDPIFSATAGQAQQLPQINVKHVTYEVFGATGTAGRVSYVDVDSRPAQANFSSLPWRYTIATTMSSVIANVVAQGDSDNLGCRITVNGEVKDEHHSSEHHAQVSCLVKAA
>NZ_CP012885.2|WP_051445812.1|3631340_3631658_+|metal-sensitive-transcriptional-regulator
MVKTAGKASLAQPRSAHASQDIEATLNRLRRAHGQLGAVISMIEQGRSCKDVVTQLAAVSRALDRAGFKIIASGLRHCLDAPGDHADGPAPLTIEELEKLFLSLA
>NZ_CP012885.2|WP_051445808.1|3630529_3631147_-|DsbA-family-protein
MTDRQPPVTASETLTLWLDPVCPFSWNTARWLSTAADEAGFNIEWRLMSLAILNAGRELPEQQQARMRDSRQVGRLMVALRDELGADAIAKAYFAFGHRYFDESAALDDDLVKHVLAAAGAHHVTAAALSDASLDAAVDDSHQASQDALGEASGSPLITIDGHTVFGPVLTSVPAADKTSAIFEAVATLVGTSEFTQLERPRTHA
>NZ_CP012885.2|WP_145929536.1|3645157_3645733_+|hypothetical-protein
MRELSLRAVANQPELSEFTPAAGLEFLVAQPRYFKKSPAAGLEFLVAQPRILNYTSLAVEMGVLDSNSASKFLGSKHFIPGGIELGIYPAEWLTSVLSKVESISRQFLNRYRERLKKYDTYQVRAIGFLSERLGSFLLISQLTELYSNNIPAEIFGYMSVIVDDNAGYSIASTDSQGGRSNRYRLNSRQAQ
>NZ_CP012885.2|WP_054585390.1|3645729_3646503_+|glucose-1-phosphate-cytidylyltransferase
MKAVLLAGGLGTRLSEETAVRPKPMVEIGGRPILWHIMKLYSHHGIQDFIVCCGYKGYVIKEYFANYFLHMSDVTFDMSVNRMEVHRHHAEPWRVTLVDTGDETLTGGRLKRVGAYIENDEAFCFTYGDGLSDVNIGASIEFHRQHGRHATVTAVLPPGRYGAIECTGDRVTGFVEKPRGDGGLINGGFFVLSPAVLDYIPGDQTAWEGPPLARLAADGEVMAFEHAGFWQPMDTLRDKNMLEDLWDSGEAPWKCWP
>NZ_CP012885.2|WP_072501355.1|3646484_3647579_+|CDP-glucose-4,6-dehydratase
MEVLALSPFGNAYSGRRVLVTGHTGFKGSWLCLWLEALGSHVVGLALDPSSEPSHWNLLNLSVEDHRVDIRDEAAVRAVLTAERPEIVFHLAAQPFVRRSYRDPVTTWATNVMGTLHLLEAVRHTPDVRAVVIVTTDKCYENREWPWAYRERDRLGGHDPYSASKAGAELVAASHRTAFLHQPSSALVATARGGNVIGGGDWSEDRLIPDLVRSVTAGEPLTIRSPHSTRPWQHVLDCLSGYLVLGQRLLAGDITCADAWNFGPDGDGNRTVEKVLSAVVRTLPQVRWQLASGTQPHEAGLLQLDSSKAKMQLGWRPVWNLDNAIDHTATWYLRFLETGEVSSIDELAAYVADAGNSGLDWATT
>NZ_CP012885.2|WP_042912253.1|3647575_3648127_+|dTDP-4-dehydrorhamnose-3,5-epimerase-family-protein
MNILDTPLPDLKIVQSLPFRDARGVFGRVFCAEELKPLLGARQIAQINHSKTSHAGAVRGLHFQRPPHAEIKMVRCLRGLVWDVAVDLRMGSPTFLQWHAEQLAQDDAQMLVIPEGFAHGFQVLEPESELLYLHTASYHPPSEGGVRHDDPRLAISWPLSPRDVSPRDLAHPLLSPDFAGVAL
>NZ_CP012885.2|WP_042912254.1|3648123_3649347_+|methyltransferase-domain-containing-protein
MKCRHCELTLTHRFVDLGFAPPSNAYLRPEDLGSPETHFPLRVNVCHECWLVQTEDYARAEELFNADYAYFSSTSSSWLDHAARFAHMVIERLQLGFESLVIEVASNDGYLLKNFKAAGIPCLGIEPTASTAAAAEALGLSVRREFFSESLGRQLAAEGRRADLIVGNNVYAHVPDINDFTRGLAAALKPEGTVTLEFPHVMPLIERTQFDTIYHEHFSYLSLTTVTRIFAMAGLRIWDVEELPTHGGSLRIFGCHAAAAIATTNRVDALLTRECEFGLTRPETYAAFQARADRLKDDLLAFLIEQKRIGQQVAAYGAAAKGNTLLNYAGVRSDLLPYVCDAAVSKQGKFMPGSHIPIRSPEELRKNPPDALIVLPWNIVEEVQNQLADLAQRGTRFVTAIPELSFL
>NZ_CP012885.2|WP_080691223.1|3649385_3650114_-|cephalosporin-hydroxylase-family-protein
MSRNDHLRAHAADFMQTSLLAKYSYNFAWMSRPIIQYPQDMIAMQELIWRVRPDLIIETGVAHGGSLIFSASMLALLDMAEAIEAGVTLDPAKSNRRVLGVDIDIRAHNRTAIEAHPMASRIEMIQGSSIAPDVVAQVNEIAAKYERVLVCLDSNHTHDHVLAELEAYAPLTSVGSYCVVFDTIVEDVPGELSADRPWGPGDNPKTAVREYLKSHAEFQIDKNIECKLLITVAPNGYLNRAA
>NZ_CP012885.2|WP_054585391.1|3650148_3651207_-|class-I-SAM-dependent-methyltransferase
MSGVTQLYEQPDFPIFQNRMYDSAGEARDCPRGDISLVQDDVSGLIYNAAFRPEVMNYDAAYQNEQAHSPLFKSHLETVANIVERTLGTHGLVEVGCGKAYFLELLQARGYSVTGFDPTYEGRNPAVQRCNFSKGVTVSARGLILRHVLEHIQNPVDFLNGLRDANGGGLIYIEVPCFDWILDARAWFDIFYEHVNYFRLEDFSRMFGRVVESGHLFGGQYLYVVADLATLRPPVSSAADRVDFPEDFLAMATVAPSNLGRGPSAVWGAASKGVIYSLLRERCGNPVSVLIDISPAKYGKFVPATGLRVMSPDEGMAALSPGSDICVMNSNYLEEIRKVTRDRFNLIGVERG
>NZ_CP012885.2|WP_042912258.1|3651206_3652034_-|NAD(P)-dependent-oxidoreductase
MTVILTGATGFVGRQILADLLERGCSVKAIVRDPSRLHGFSADGTLTFARTRDLFAEGTGRLEELLDGSEILVHAAWHAEPGEYLTSPLNLACLTGTVHLARAFSAVGGKRFVGIGTCAEYDTSAGLMTIDTPLAPNTLYAVCKAAAYQVLRCFLEENMSFAWCRLFYLYGEGEDERRLVPYIRRQLGAGQQVLLTRGDQVRDFIDVKDAARMVVDVALGREEGAVNICSGEAVTVRQLAERIADEYGRRELLRFGARPENTFDPPRVVGVRKDV
>NZ_CP012885.2|WP_069953849.1|3652406_3653057_-|hypothetical-protein
MKKFWDEVNEVAFAAQQRLGRLQVPEMPHFDSPESTSWFLDQLGGAKRYLEYGTGGSTYQAARVGVDFIAVDTDPYFLDAVRTKIQDAGLAKPGQVFRHADIGRTGTWGRPRGKINDARRQSFHRASDPPPECVEGLLPDLVLIDGRFRVACAFKVFNMLNAQTGWTVVVDDYTQRPQYREIEDYADVKLVGRMAVIQSARPVPSNVISHWETDFN
>NZ_CP012885.2|WP_042912260.1|3653434_3654751_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MKISVIGSGYVGLVTGACLADSGNDVVCVDIDKAKIDLLLAGGVPIFEPGLAELIARSRENGLIDFTTDKQRGIEHGDVIFIAVPTPMGESGAADLSHVFSAAADIGSYMDRYKVVVDKSTVPVGTADKVRAIIRTKTTHEFDVVSNPEFLKQGKAIADFMQPDRVVIGSDSERALKVMEDLYEPFLRTFHPLIAIDVKSAEMAKYAANCFLATKISFINEMSNLCEKAGADISAVREAIGADKRIGYDFLFPGIGYGGSCLPKDVRALLHTASRFGSETHLLHAVEHVNNQQKEALVSKIITRFAGERVNTDLRGLRIALWGLSFKPQTDDVRAAPSLVIAKNLTECGARVRAFDPEATEQAQKVLGDSIEYARNMYEAAEDADALLLLTEWKQFQRPSWQRVKSAMRQHVVFDGRNVYDPERMRAEGFEYYGMGRI

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Crispr_ID: NZ_CP012885_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012885_5

4114133-4114229

Orphan

Consensus_repeat	Method
TGCCCGGCGTCGGCTGTGGCTCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012885_5

>merge|NZ_CP012885|5|4114133-4114229|CRISPRCasFinder
TGCCCGGCGTCGGCTGTGGCTCCGGTGGCCAGTTCGCCGGCCCCGGCGGCGTGCCCGGCGGCACCGGCTGCCTGCCCGGCGTCGGCTGCGGCTCCGG

>NZ_CP012885|5|5|4114133-4114229|CRISPRCasFinder
TGCCCGGCGTCGGCTGTGGCTCCGG	TGGCCAGTTCGCCGGCCCCGGCGGCGTGCCCGGCGGCACCGGCTGCC
TGCCCGGCGTCGGCTGCGGCTCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012885.2\|WP_042912578.1\|4122997_4124080_-\|dihydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|226326
NZ_CP012885.2\|WP_042913037.1\|4120790_4121528_-\|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|234595
NZ_CP012885.2\|WP_008258652.1\|4125205_4125856_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|132427
NZ_CP012885.2\|WP_042912573.1\|4114252_4117489_-\|carbamoyl-phosphate-synthetase	unknown	unknown	gnl\|CDD\|237263
NZ_CP012885.2\|WP_036453354.1\|4109128_4109929_-\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|234984
NZ_CP012885.2\|WP_042912581.1\|4124076_4125084_-\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|239607
NZ_CP012885.2\|WP_042913030.1\|4104639_4105542_-\|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl\|CDD\|235107
NZ_CP012885.2\|WP_042912569.1\|4110737_4111850_-\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP012885.2\|WP_042913034.1\|4119081_4119891_+\|thioesterase-family-protein	unknown	unknown	gnl\|CDD\|379298
NZ_CP012885.2\|WP_172417532.1\|4117485_4119021_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341286
NZ_CP012885.2\|WP_042912568.1\|4109971_4110721_+\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|366780
NZ_CP012885.2\|WP_008258618.1\|4105671_4106424_-\|FAD-dependent-thymidylate-synthase	unknown	unknown	gnl\|CDD\|234847
NZ_CP012885.2\|WP_042912571.1\|4111846_4113046_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173841
NZ_CP012885.2\|WP_009952956.1\|4120335_4120794_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_051445912.1\|4107737_4108472_-\|cell-division-protein-DivIVA	unknown	unknown	gnl\|CDD\|274008
NZ_CP012885.2\|WP_042913032.1\|4113042_4113825_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235975
NZ_CP012885.2\|WP_008258621.1\|4108571_4109057_-\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NZ_CP012885.2\|WP_008258632.1\|4119881_4120343_-\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NZ_CP012885.2\|WP_042912564.1\|4106473_4107685_-\|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225755
NZ_CP012885.2\|WP_042912576.1\|4121632_4122991_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|367155

Protein	Function_ID	Function_description	E-value
NZ_CP012885.2\|WP_042912578.1\|4122997_4124080_-\|dihydrodipicolinate-reductase	gnl\|CDD\|226326	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown].	1.66987e-38
NZ_CP012885.2\|WP_042913037.1\|4120790_4121528_-\|4-hydroxy-tetrahydrodipicolinate-reductase	gnl\|CDD\|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	4.13355e-99
NZ_CP012885.2\|WP_008258652.1\|4125205_4125856_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|132427	TIGR03384, betaine_BetI, transcriptional repressor BetI. BetI is a DNA-binding transcriptional repressor of the bet (betaine) regulon. In sequence, it is related to TetR (pfam00440). Choline, through BetI, induces the expression of the betaine biosynthesis genes betA and betB by derepression. The choline porter gene betT is also part of this regulon in Escherichia coli. Note that a different transcriptional regulator, ArcA, controls the expression of bet regulon genes in response to oxygen, as BetA is an oxygen-dependent enzyme. [Regulatory functions, DNA interactions].	0.000338941
NZ_CP012885.2\|WP_042912573.1\|4114252_4117489_-\|carbamoyl-phosphate-synthetase	gnl\|CDD\|237263	PRK12999, PRK12999, pyruvate carboxylase; Reviewed.	5.77895e-168
NZ_CP012885.2\|WP_036453354.1\|4109128_4109929_-\|thymidylate-synthase	gnl\|CDD\|234984	PRK01827, thyA, thymidylate synthase; Reviewed.	0
NZ_CP012885.2\|WP_042912581.1\|4124076_4125084_-\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|239607	cd03531, Rieske_RO_Alpha_KSH, The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway, catalyzing the 9 alpha-hydroxylation of 4-androstene-3,17-dione (AD) and 1,4-androstadiene-3,17-dione (ADD). KSH is a two-component class IA monooxygenase, with terminal oxygenase (KshA) and oxygenase reductase (KshB) components. KSH activity has been found in many actino- and proteo- bacterial genera including Rhodococcus, Nocardia, Arthrobacter, Mycobacterium, and Burkholderia.	7.16801e-30
NZ_CP012885.2\|WP_042913030.1\|4104639_4105542_-\|4-hydroxy-tetrahydrodipicolinate-synthase	gnl\|CDD\|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	7.08269e-146
NZ_CP012885.2\|WP_042912569.1\|4110737_4111850_-\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	3.57619e-42
NZ_CP012885.2\|WP_042913034.1\|4119081_4119891_+\|thioesterase-family-protein	gnl\|CDD\|379298	pfam13622, 4HBT_3, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	9.53006e-22
NZ_CP012885.2\|WP_172417532.1\|4117485_4119021_-\|AMP-binding-protein	gnl\|CDD\|341286	cd17631, FACL_FadD13-like, fatty acyl-CoA synthetase, including FadD13. This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.	2.33369e-133
NZ_CP012885.2\|WP_042912568.1\|4109971_4110721_+\|dienelactone-hydrolase-family-protein	gnl\|CDD\|366780	pfam01738, DLH, Dienelactone hydrolase family.	3.47996e-60
NZ_CP012885.2\|WP_008258618.1\|4105671_4106424_-\|FAD-dependent-thymidylate-synthase	gnl\|CDD\|234847	PRK00847, thyX, FAD-dependent thymidylate synthase; Reviewed.	3.54e-100
NZ_CP012885.2\|WP_042912571.1\|4111846_4113046_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	1.80373e-131
NZ_CP012885.2\|WP_051445912.1\|4107737_4108472_-\|cell-division-protein-DivIVA	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	2.28412e-05
NZ_CP012885.2\|WP_042913032.1\|4113042_4113825_-\|SDR-family-oxidoreductase	gnl\|CDD\|235975	PRK07231, FabG-like, SDR family oxidoreductase.	1.12702e-124
NZ_CP012885.2\|WP_008258621.1\|4108571_4109057_-\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	5.01316e-61
NZ_CP012885.2\|WP_008258632.1\|4119881_4120343_-\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	1.40179e-12
NZ_CP012885.2\|WP_042912564.1\|4106473_4107685_-\|winged-helix-turn-helix-domain-containing-protein	gnl\|CDD\|225755	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown].	1.37232e-105
NZ_CP012885.2\|WP_042912576.1\|4121632_4122991_+\|HNH-endonuclease	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	3.2479e-79

>NZ_CP012885.2|WP_042913032.1|4113042_4113825_-|SDR-family-oxidoreductase
MTSQDLTGRTAIITGASRGIGLSIAQQLAAAGANVVLTARKQEAADEAAAQVGERAVGVGAHAVDEDAARRCVDMTLERFGTLDILVNNAGTNPAYGPLIDQDHARFTKIFDVNLWAPLLWTSLAVKSWMGEHGGSIVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPRVRVNAICPGVVRTRLAEALWKDHEDPLASSIALGRIGEPIDVAAAVAFLVSDAASWITGETMVIDGGLLLGAAQGFRPAPGGGQ
>NZ_CP012885.2|WP_042912571.1|4111846_4113046_-|acyl-CoA-dehydrogenase-family-protein
MNAVDTAELDARVQALLDEHDPNESDAREFLGAQYDAGLAWVHLPRGFGGLDLPRTAQDRVDARLAAAGAPVGGTPKNYIGMGMAAPTIAAFGTDEQKRKFLRPLFTGEQIYCQLFSEPGGGSDLAGVSTRAVRDPHNPEDWIVNGQKVWTSQAQHAHMAILVARTDPAVPKHAGLTYFLCDMTQPGVEIRPLRQITGEAEFNEVFLTDVRVPDANRLGPEGGGWRVATTTLNNERVAIGSRAGAPREGGHIGKVADAWRAEPALRDPAMHDQLMRLWVEAEVFRLAGERLRQQAATGQPGPEGAGMKVAFAKLAQAISGFEIELHGESGLYYDDWTLRRPETVDLVGRGPGYRYLRARGNSIEGGTSEILRNTISERILGLPGEHRVDKDAAWKDLPR
>NZ_CP012885.2|WP_042912569.1|4110737_4111850_-|acyl-CoA/acyl-ACP-dehydrogenase
MSSLRAATGDLLYSDTEEALRAGVRQLFAERCPPESVAGVYDAQPQDFSGVWRTLATELGVAGLLVPESLGGAGASAREAAVVMEEIGRAVAPVPFLSSAVLATVALLRAGDTRTVSGLAQGELTAALVVPLTTAPGDPVTGVSGGPGGLSGSVTAVAGAGEADVLVVPVTGPDGLELHTVDRAAAGVQVSPLLALDMTRPLAAVTFSGAPSSKVGAGDGPVADAVRTGAALLASEQLGVAQWCFDTTLDYAGQRRQFGRTIGSYQAIKHRLADLWFDVGAAAAAARYAADTCARADDDAAAAAAIAQAYCSDIAVHAAEECIQLHGGIGMTWEYPAHLYLKRAKSDQLAFGTGYRHRARLAELVNLPPT
>NZ_CP012885.2|WP_042912568.1|4109971_4110721_+|dienelactone-hydrolase-family-protein
MPNITDVVTTPDGTCPVHLFTPDGPESQVPWPGVVMYPDAGGVRGTFEEMAARLAGFGYAVLLPDVYYRTADWAPFDMATVFNDQSERGRLFSMIGSVTPDRMAADATAFFDYLAARPEVSGERFGVCGYCMGGRTSLIVAGRVPDRVAAAASFHGGGLVTDTDDSPHLLADRMSATVYVGGAQNDASFTADHAEQLDKALTAAGVEHTIEWYSAGHGFAVPDNAPYDPAAAERHWDAMTDVFAAAFPR
>NZ_CP012885.2|WP_036453354.1|4109128_4109929_-|thymidylate-synthase
MPIPTPYEDLLRLVLDEGTAKSDRTGTGTRSLFGRQLRYDLSAGFPLLTTKKVHLKSVVYELLWFLRGDSNVGWLREHGVTIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPNSRRIIVSAWNVGEIPQMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQSGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELVLGERDSIFDYTYDDVVVRNYDPHPAIKAPVAV
>NZ_CP012885.2|WP_008258621.1|4108571_4109057_-|dihydrofolate-reductase
MGLVWAQSTSGVIGRGGGIPWNVPEDLARFKEVTIGHTVVMGRRTWDSLPAKVRPLPGRRNVVLSREDGFAADGAQVVGSLDAAFARAEGEPAVWVIGGGQVYLAALPYATRCEVTEIELDLRRDDDDALAPALDDTWVGETGEWQASRSGLRYRFHSYRR
>NZ_CP012885.2|WP_051445912.1|4107737_4108472_-|cell-division-protein-DivIVA
MITEPVKTFSRKFMGYDASAVDAHIEMLTTKQQLLLDDVESLRARLQESGEQTAALRKEVAALTDTSPSSHAMQKRMAKMLQRAVDEVAEMQAEARAEADALIAAAEAEAEAAERKRDEVLADMAAQQKALEAEYEQTKEKLDAELAEMRAETQAAIDEARRNAERECERLLGDAKQGADHYRDKARRAVDEATAQRIEILEQLMGVYRDLDGVPAALEAAYQEQKNPSEDGALAPVDGKVRAS
>NZ_CP012885.2|WP_042912564.1|4106473_4107685_-|winged-helix-turn-helix-domain-containing-protein
MSTRRLSAAQARRIAVAAQGFTEPRPGGQITRVHLKRLISRIQVLQLDSVSVAVRAHYAPVFSRLGPYDRDVLDRAAWGLRSSRLLAEYWAHEAALMAVEDWPLLRWRMRQYRHGRWGTHIVKANPRLAEKVVAAVAELGPSTAGQIEAHLAAGPRGPRGSWWGSRSDTKWVAEALFSAGVLTTATRVGFARHYDLVERVLPAAVLAREVDDDEALRELTLRAATALGVGTEADIRDYFRLSAAQVKPAIAQLLAAGDIERVDVDGWSGPAYLRAGRTVPRVDRGTALLCPFDPLIFFRPRVERLFEFHYRIEIYTPAAKRQYGYYVWPLLMDGRLVARVDLKADRPADTLRVVGTFAEPDAPKARVAAALAGELRSMASWLGLGGFSVSGRGDLAADLRAIS
>NZ_CP012885.2|WP_008258618.1|4105671_4106424_-|FAD-dependent-thymidylate-synthase
MAEIAPLRVQLIAKTEFLAPPDVPWSTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYIKHIIDVGHLSVLEHASVSFYITGLSRSCTHELIRHRHFSYSQLSQRYVPETDSHVVVPPGMEDDPELRQILAAAADASRATYTELLAKLEAKFADQPNAVLRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAGAAPAVFADFEISALADGTEVATSPLATEA
>NZ_CP012885.2|WP_042913030.1|4104639_4105542_-|4-hydroxy-tetrahydrodipicolinate-synthase
MSTAGFDAPARLGTVLTAMVTPFRPDGSLDTATAAHLANHLIDAGCDGLVVSGTTGESPTTTDDEKRELLRVVLEAVGDRARVIAGAGSYDTAHSVRLAKACAAEGAHGLLVVTPYYSKPPQSGLIAHFTTVADATALPVVLYDIPPRSVIPIQPETIRALAAHPNIVGIKDAKADLHSGGQIIAETGLAYYSGDDALNLPWLAMGATGFISVISHVAANQLREMLSAFNSGDIATARKINSTVAPLCDAMARLGGVTLSKAGLRLQGIDVGDPRLPQMPATPEQIDALAVDMRAASVLR
>NZ_CP012885.2|WP_042912573.1|4114252_4117489_-|carbamoyl-phosphate-synthetase
MSASLLVANRGEIALRIIRTATELGMRTIAVYADDDAQSPHVHAADEAIVLPGSGPRAYLDQSAMLAVAKRTGADLIHPGYGFLSENAEFADACVAGGVTFVGPDPGVLGLLGNKTAARGAALAAGVPVLPATDGASSVEEVAAFFAAQRGGIMLKALAGGGGRGMRKVHRADQIDDAYQRCAAEAQLGFGDPALYAEALLDDARHIEVQVVAAPAGHQTHALAVGDRDCSIQRRYQKLVEIAPAQGLSDELRRALHQAAVRLCARVGLRGLATVEFLVTGEDFVFLEANPRIQVEHTVTEEITGLDLVAVQLAIAGGTSFYGLGLPAGIASDGLEVIGEPAAQRGIAIQLRVNAETFGPDLSVLPSAGTLTAFTPPSGPGVRVDTYGRPGLAVSPQYDSLLAKVIVHVRGTSWPAALRKADTALSEFGIEGIHTNIGFLRELLRAERVESGWVSTGFVDEKLPELARATQSHQQEPPPASVELYPGEEALRAQLAGTVVEVAPEGVEHAAGSQLVVLEAMKMQHVLVAPDALRTVRTLVTPGQVVGTGDPLLIFTRTESGNDGESARAATDLDRPRADLDEVTRRHALTLDEGRAAAVAKRHQQGRRTARENIADLVDPGSFVEYGALAIAAQRSRRSEEDLIANTPADGLVAGLATIGAQRFGRAAAQAVVVSYDYTVLAGTQGMRNHAKTDRAFDLAARKRLPVVLFAEGGGGRPGDTDVGGAAGLDVPTFRMLAGLRGEVPLVSIVSGRCFAGNAALAGVCDVIIATPDANIGMGGPAMIEGGGLGVYPPEAIGPIGVQRRNGVVGLVARDEAHAVALAKQYLSYFQGSLGEWEEPDPRLARHVVPQNRLRAYDVHRAIEAIVDVGSVLELRPDYGVGIVTALVRVEGVPYGLIANSTHHLGGAIDAEAADKTGDFLALCESFGLPVISLCDTPGFMVGPDAETQAAVRRFGRMFVLGARLTVPLGMIILRKAYGLGAMAMAGGSFRAPQFTIAWPTGEIGGMGLEGAVRLGYSKELAAAEESGDPAERQSLFDRLVAAAYEHGKALRAATTFELDDVIDPSASRAWITRLSGG
>NZ_CP012885.2|WP_172417532.1|4117485_4119021_-|AMP-binding-protein
MPPVIEIARDHNPFPTVGVSRGRDGVPRYDELPATLLDMLAEHVDTRPGSEAVVELGGGRLTYRQLWDRSARVAGGLRAEGIKRGDRVAVRYPAGIDWVLAFWGVVMAGGIAVAVNTRSAQPEVDFVLSDSGAGLDLAPDSPLPDGPPYVSEHLGRADVAALFYTSGTTGHPKGVPTTHEAFLTNTENSLRCSGFARDVGERLRTLISVPLFHVTGCNTQLLVAMRLGGTSVIMPTLNLDELITVLTTERISLMVTVPAVYALLLRHKAFAGTDVSGVRWVGYGGAPIAPSLVRAVQNAFPQATVFNGYGMTETASLATVLPHHDAVEHADSVGYAVPSVDLGVIPFDEDEPGVGELVVRGANVTGGYWNRPEANAATFTDGWLHTGDVVRVDDAGRVHLIDRLKDIINRGGENVSSVEVEAVLLAAPHVADACVLGVPDDVMGEKVGAVLFGGDDDIDVPAVLEHCRGRLADFKVPQYVTVVDTALPRNAGGKLLKARLREQVRWGDPLR
>NZ_CP012885.2|WP_042913034.1|4119081_4119891_+|thioesterase-family-protein
MPEAFFTVDGDSYVPGAMTQGPWGAAMGGQIVGGLLGWGIEQSGVDADLQPARFTVDLLRPALMSPVQIRTSVLREGRRIKLVDGELVQNGTVVARASALFLRRGDHPDGRVWSFPVEMPPLPTSSDGFPEAMPFLIWGYGATRDGSPGIAAGEWEQSDSQKFAWARIFRPMVQGHPLTPFTRLAFAGDITSSLTHWGTGGLRYINADYTVTASRLPDGEFLGLAAQSHYGTAGVATGAATLFDRHGPLGTSSALALAQPADAFKPTYA
>NZ_CP012885.2|WP_008258632.1|4119881_4120343_-|flavodoxin-family-protein
MSKTLLIVHHTPSPHTHEMFEAVVSGATDPEIEGVEVLRRPALTVSPAEMLAADGYLLGTPANLGYISGALKHAFDCSYYQLLDSTRGRPFGLYLHGNEGTEGAERAVDTITTGLGWSKAAETVVVSGKPGKEQLQACWELGATVAAQLMDYA
>NZ_CP012885.2|WP_009952956.1|4120335_4120794_-|hypothetical-protein
MTKALRTQLLVAFMCVALLVYFALLGRVAVAMIASGRAAAVGLGLAVLVMPVIGLWAMVATLRAGFAHQRLARLIAADGMELDTSDLPRRPSGRIQRDAADALFATVRTEVEDHPDDWRRWYRLARAYDYAGDRRRAREAMKTAVNLQGDHE
>NZ_CP012885.2|WP_042913037.1|4120790_4121528_-|4-hydroxy-tetrahydrodipicolinate-reductase
MRVGVLGAKGKVGSTMVAAVQAAEDLTLSAEVDAGDPLSLLTDGGTEAVIDFTHPDVVMGNLEFLIGNGIHAVVGTTGFTAERLQQVRAWLAESPKTSVLIAPNFAIGAVLSMHFARQAAPFFDSAEVIELHHPHKADAPSGTATRTAKLIAESRKGLPPNPDATSTSLPGARGADVDGIPVHSVRLAGLVAHQEILFGTEGETLSIRHDSLDRTSFVPGVLLAVRRITEHPGLTVGLEPLLNLQ
>NZ_CP012885.2|WP_042912576.1|4121632_4122991_+|HNH-endonuclease
MHSIEVPPEVSAALDALDAAAAAIRGLNFDQLDPAVRLRALERMEASRRRQIAVSHDVIAGLAREDPAALGGPVHKVIADWLRIGCGEASRRLHDATRLSPRLTLTGQELPPELPATAVAWRDGLLDGQHLRVIQSFVRDLPASTPVAKVETAERFLANEAAKLRPDQLQKLAHRYALSINPDGKFSDADRARQRGFTWCGQSPDGMSVGKLVASPELRANLDAWMSHFAAPGMCNPDDETPCVAGEPDDERVRRDLRSHAQRQHDALNALVRGQLGDPKLGQHNGLPVAVIVATTLRELTSGTGRAVTGGGTLLPMRDVIRMGRHAYHYLAVFDEHSSRPLYLGRSRRIASPDQRVVLYAQDRGCTHPGCDAPGYWCEAHHLKEWAAGGATDADNLTFACGPHHRLVEKGWRTRKNARGDTEWIPPPRLDRGVRTNDYHHPERGIGDRAGP
>NZ_CP012885.2|WP_042912578.1|4122997_4124080_-|dihydrodipicolinate-reductase
MSTAPIRVFQVGSGNVGSEMIRRIATQPDLELIGVHAYSPEKVGTDTGEFAGLGTNGVKFTGTIEEIIAAKPDVLTFHGVFPDEDLYLHVLEAGIDIVTTADWITGWHRDTNHPHPSGKPVSKLLAEACEKGGATFYGTGMNPGLNQILGVVCSADVADIENITTIESVDVSCHHSKDTWIEVGYGQPVDDPDIPSKLEKYTRVFADSVYMMADCFDLTLDEVTFSYELGACTKDVDLGWYTLPKGSLGGNYIRYQGMVDGVPRVETHLEWQMTPHTDPSWNIKGCYITQIKGDPCIYNKHMIFPKPGVDLSNPDSFASIGMTVTGMPALAAIKSVIAAPPGLITSADLPLRGFAGRFKK
>NZ_CP012885.2|WP_042912581.1|4124076_4125084_-|Rieske-2Fe-2S-domain-containing-protein
MAKPPLSMKPTGWFQVAWSDEIGVGDVHKIKYFDSEMVAWRAESGQLTVMNAYCEHLGAHLGYGGTVVGEVLQCPFHGWQWSADGRNVCIPYQDRPNRGRRMRTYPVVERNASVYIWHDVERREPYFEPPDVFAAFDDGSSADDYYPQQRLYRETLEMHPQYVLENGVDFAHFKFVHKTPIVPVFTRHDFAEPVSYVDFTITFEGDDGQKIEDVNSGVQAINGGLGIAVTKSWGMIDNRTISAITPVDERTSDVRFMVYIGRAPGGDSERAERKAAEFGQEVIRQFTQDIEIWQHQRYSDPPALAPDEYEGFTAIRQWAKQFYPEAFVSQEGLAQ
>NZ_CP012885.2|WP_008258652.1|4125205_4125856_+|TetR/AcrR-family-transcriptional-regulator
MTRQTSGAGIAGRRPNRRGHATRESMLEAALRSLASGEPGSVSANRIAKDIGATWGAVQYQFGDTDGFWAAVLHRTAERRAATFSTLSAPISPDAPLRERVGAIIDTLYTGLASADSRAIENLRAALPRDPDELERLYPRTAAELFSWGKSWLETCQQAFAGLAVDPDRVREVAALIPGAMRGLVSERQLGSYADLDMARRGLTNALAAYLEPSRP

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Crispr_ID: NZ_CP012885_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012885_6

4655362-4655495

Orphan

Consensus_repeat	Method
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012885_6

>merge|NZ_CP012885|6|4655362-4655495|CRISPRCasFinder
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTACCCCCGAGCGCCCACTCCTCCGCATCCCGTCCCCCTCGCCGCTGCGCGGCTGGGGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC

>NZ_CP012885|6|6|4655362-4655495|CRISPRCasFinder
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC	CCCCGAGCGCCCACTCCTCCGCATCCCGTCCCCCTCGCCGCTGCGCGGCTGG
GGGCGGTACCCCCGGCGCGGAATGCATCGTCGCCGGGCTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012885.2\|WP_042913107.1\|4642854_4643505_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|188314
NZ_CP012885.2\|WP_042913114.1\|4655506_4655761_+\|mycoredoxin-Mrx1	unknown	unknown	gnl\|CDD\|131255
NZ_CP012885.2\|WP_008259631.1\|4651131_4652475_+\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|223733
NZ_CP012885.2\|WP_014712233.1\|4665450_4665762_+\|MGMT-family-protein	unknown	unknown	gnl\|CDD\|226219
NZ_CP012885.2\|WP_026071234.1\|4644590_4647569_-\|UPF0182-family-protein	unknown	unknown	gnl\|CDD\|234609
NZ_CP012885.2\|WP_042913116.1\|4664662_4665448_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP012885.2\|WP_014712227.1\|4655772_4656705_-\|NAD(+)-diphosphatase	unknown	unknown	gnl\|CDD\|234699
NZ_CP012885.2\|WP_009955776.1\|4647642_4648665_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|226011
NZ_CP012885.2\|WP_161807805.1\|4648771_4650148_+\|zinc-dependent-metalloprotease	unknown	unknown	gnl\|CDD\|227607
NZ_CP012885.2\|WP_173662738.1\|4643606_4644587_+\|DJ-1/PfpI-family-protein	unknown	unknown	gnl\|CDD\|227311
NZ_CP012885.2\|WP_042913109.1\|4650183_4651050_+\|cyclodehydratase	unknown	unknown	gnl\|CDD\|274832
NZ_CP012885.2\|WP_008259653.1\|4656704_4657775_-\|potassium-channel-family-protein	unknown	unknown	gnl\|CDD\|367001
NZ_CP012885.2\|WP_008259667.1\|4665768_4666623_-\|TIGR02569-family-protein	unknown	unknown	gnl\|CDD\|131620
NZ_CP012885.2\|WP_161807807.1\|4667927_4668761_-\|DUF3152-domain-containing-protein	unknown	unknown	gnl\|CDD\|371483
NZ_CP012885.2\|WP_162494288.1\|4652878_4653040_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_042913117.1\|4666658_4667846_-\|adenylyltransferase/sulfurtransferase-MoeZ	unknown	unknown	gnl\|CDD\|181156
NZ_CP012885.2\|WP_161807806.1\|4653140_4655252_-\|ATP-dependent-DNA-helicase-UvrD2	unknown	unknown	gnl\|CDD\|223288
NZ_CP012885.2\|WP_080691230.1\|4664380_4664617_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_072501415.1\|4661167_4664293_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NZ_CP012885.2\|WP_042913111.1\|4652484_4652736_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791

Protein	Function_ID	Function_description	E-value
NZ_CP012885.2\|WP_042913107.1\|4642854_4643505_-\|HD-domain-containing-protein	gnl\|CDD\|188314	TIGR03401, Uncharacterized_protein_YFL061W/YNL335W, HD domain protein, cyanamide hydratase family. Members of this protein family are known, so far, in the Ascomycota, a branch of the Fungi, and contain an HD domain (pfam01966), found typically in various metal-dependent phosphohydrolases. The only characterized member of this family, from the soil fungus Myrothecium verrucaria, is cyanamide hydratase (EC 4.2.1.69), a zinc-containing homohexamer that adds water to the fertilizer cyanamide (NCNH2), a nitrile compound, to produce urea (NH2-CO-NH2). Homologs are likely to be nitrile hydratases.	2.07454e-16
NZ_CP012885.2\|WP_042913114.1\|4655506_4655761_+\|mycoredoxin-Mrx1	gnl\|CDD\|131255	TIGR02200, conserved_hypothetical_protein, Glutaredoxin-like protein. This family of glutaredoxin-like proteins is limited to the Actinobacteria and contains the conserved CxxC motif.	4.87391e-42
NZ_CP012885.2\|WP_008259631.1\|4651131_4652475_+\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	3.1123e-124
NZ_CP012885.2\|WP_014712233.1\|4665450_4665762_+\|MGMT-family-protein	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	6.81839e-30
NZ_CP012885.2\|WP_026071234.1\|4644590_4647569_-\|UPF0182-family-protein	gnl\|CDD\|234609	PRK00068, PRK00068, hypothetical protein; Validated.	0
NZ_CP012885.2\|WP_042913116.1\|4664662_4665448_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.28646e-16
NZ_CP012885.2\|WP_173662738.1\|4643606_4644587_+\|DJ-1/PfpI-family-protein	gnl\|CDD\|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	3.3666e-79
NZ_CP012885.2\|WP_009955776.1\|4647642_4648665_-\|PDZ-domain-containing-protein	gnl\|CDD\|226011	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms].	2.9985e-141
NZ_CP012885.2\|WP_014712227.1\|4655772_4656705_-\|NAD(+)-diphosphatase	gnl\|CDD\|234699	PRK00241, nudC, NAD(+) diphosphatase.	1.62433e-124
NZ_CP012885.2\|WP_042913109.1\|4650183_4651050_+\|cyclodehydratase	gnl\|CDD\|274832	TIGR03882, hypothetical_protein, bacteriocin biosynthesis cyclodehydratase domain. This model describes a ThiF-like domain of a fusion protein found in clusters associated with the production of TOMMs (thiazole/oxazole-modified microcins), small bacteriocins with characteristic heterocycle modifications. This domain is presumed to act as a cyclodehydratase, as do members of the SagC family modeled by TIGR03603.	0.000510201
NZ_CP012885.2\|WP_008259653.1\|4656704_4657775_-\|potassium-channel-family-protein	gnl\|CDD\|367001	pfam02254, TrkA_N, TrkA-N domain. This domain is found in a wide variety of proteins. These protein include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.	9.10223e-24
NZ_CP012885.2\|WP_008259667.1\|4665768_4666623_-\|TIGR02569-family-protein	gnl\|CDD\|131620	TIGR02569, conserved_hypothetical_protein, TIGR02569 family protein. This protein family is found, so far, only in Actinobacteria, including as least five species of Mycobacterium, three of Corynebacterium, and Nocardia farcinica, always in a single copy per genome. The function is unknown. [Hypothetical proteins, Conserved].	4.73137e-135
NZ_CP012885.2\|WP_161807807.1\|4667927_4668761_-\|DUF3152-domain-containing-protein	gnl\|CDD\|371483	pfam11350, DUF3152, Protein of unknown function (DUF3152). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	9.38789e-130
NZ_CP012885.2\|WP_161807805.1\|4648771_4650148_+\|zinc-dependent-metalloprotease	gnl\|CDD\|227607	COG5282, COG5282, Uncharacterized conserved protein [Function unknown].	6.68994e-161
NZ_CP012885.2\|WP_161807806.1\|4653140_4655252_-\|ATP-dependent-DNA-helicase-UvrD2	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	5.60173e-121
NZ_CP012885.2\|WP_042913117.1\|4666658_4667846_-\|adenylyltransferase/sulfurtransferase-MoeZ	gnl\|CDD\|181156	PRK07878, PRK07878, molybdopterin biosynthesis-like protein MoeZ; Validated.	0
NZ_CP012885.2\|WP_072501415.1\|4661167_4664293_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	4.25e-69
NZ_CP012885.2\|WP_042913111.1\|4652484_4652736_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	2.08659e-14

>NZ_CP012885.2|WP_161807806.1|4653140_4655252_-|ATP-dependent-DNA-helicase-UvrD2
MPTVADPLTAGLDDEQREAVLAPRGPVCVLAGAGTGKTRTITHRIAQLVAGGHVAAGQVLAVTFTQRAAGEMRSRLRAIDAAAGMGPAVGAVSALTFHAAAHRQLRYFWPRVVGDTGWQLLDSKFAVVARAASRARLNASTDEVRDLAGEIEWAKASLIGPEEYPTAVAAAGRDIPLDAAQIAGVYAAYEALKARGEHVTLLDFDDLLLHTAAAIENDPAVAEEFRDRYRCFVVDEYQDVTPLQQRVLTAWLGDRDDLTVVGDANQTIYSFTGASPRFLLDFSRRFPDATVVRLERDYRSTPQVVSLANQVIAAARGRVAGSKLHLVGQRPPGPAPMFHEHPDEPAEAAAVAASIGRLIESGTPPSEIAVLYRVNAQSEIYEEALTEAGIAYQVRGGEGFFNRQEIKQALLALHRASERATARGAEGPLPDVVRAVLEPLGLTAQEPVGTRARERWEALSALAELVDDEVAQRPQLDFPGLLAELRMRADARHPPVVQGVALASLHAAKGLEWDAVFLVGLADGTLPISHALAHGAESEAVEEERRLLYVGITRARTHLALSWALARSPGGRQGRKPSRFLNGIAPQARAEAGPNKSRRNRATATRCRICNNNLTTPAAVMLRRCETCAADIDEDLLLRLKAWRLDVAKEQKVPAYVVFTDNTLIAIAELRPDDDEALIAIPGIGARKLEQYGPDVLELVRGR
>NZ_CP012885.2|WP_162494288.1|4652878_4653040_-|hypothetical-protein
MLSDAFGAGVARAELSAGTSHAAHAAVSAAARKHRAAAATDASVGVGGPPKAT
>NZ_CP012885.2|WP_042913111.1|4652484_4652736_-|WhiB-family-transcriptional-regulator
MSAPTAPRPHLPCHAGDPDLWFAEAPADLERAKSLCVDCPVRRQCLAAALERAEPWGVWGGEIFDRGSVLSFKRPRGRPRKAA
>NZ_CP012885.2|WP_008259631.1|4651131_4652475_+|AarF/ABC1/UbiB-kinase-family-protein
MDDGYVADIKRGRAARNAKLASIPVGFAGRAALGFGKRLTGKSRDEVQAELLEKAAHQLFTVLGELKGGAMKVGQALSVLEAAIPEEFGEPYREALTKLQKDAPPLPAAKVHRVLDAQLGTKWRERFSSFDDTPVASASIGQVHKGVWSDGREVAVKIQYPGADEALRADLKTMQRLVGVFKQLAPGADIQGVVDELIERTEMELDYRLEAENQRAFAKAYHDHPHFAVPRIVASAPKVVIQEWMQGIPMAEIIRHGTTEQRDLVGTRLLELTFDAPRRLEMLHGDAHPGNFMLLDDGRMGVIDFGAVAPLPGGLPIELGMSIRLARDKNYDLLLPTMEKAGFIQKGQQVSVRDIDDMLRQYVEPVEVEVFHYTRKWLQKMSAIEIDRSVSQIRTARQMDLPPKLVIPMRVIMSVAAILCQLDAHVPIKALSEELVPGFAEPDNAVV
>NZ_CP012885.2|WP_042913109.1|4650183_4651050_+|cyclodehydratase
MTQQCQAALSTYALDPAMPVLLRPDGAVQVGWDPRRAVLVRPPGGLAAAELATLLRTMSSPTPLPELQRRALDRGLTDTEGLRSLVAQLVRAGVATECGRPRGRAPSVRVHGRGPLSELLVESLRCSGARIAHSSQPHAAVSAGDVDLVVLSDYLVADPRMVRDLHDQGVAHLLVRVRDGIGLVGPLVIPGVTSCLGCADLHRRDRDAAWPAICAQLRETVGVADRATVLATAALALSQVNRVIAAVRGQDAASEPEPPQTLNATLEFDLHAGAIVARQWVKHPLCAC
>NZ_CP012885.2|WP_161807805.1|4648771_4650148_+|zinc-dependent-metalloprotease
MSTVGVMADLPFGFSPGEDPDKHGKKDPDSGSNPSDPFAAFGMSGDFGMGDLGQIFTQLGQMFSSAGTVGPGGTASGPVNYELARRVASNSIGFVAPVPDTTNSAIADAVHLAETWLDGATALPAGTAKAVGWTPADWVDNTLETWKRLCDPMAQQISTVWAASLPEEAKSMAGPLLQMMSQMGGMAFGSQLGQALGRLSREVLTSTDIGLPLGPKGIAAIMPDAVESFTTGLERPRSEILTFLAAREAAHHRLFSHVPWLSSQLLGAVEAYAMGMQIDMSGIEELARDFNPASLSDPAAIENLLGQGVFEPKATPAQTQALERLETLLALIEGWVQVVVAAALGDRIPGAGALGETLRRRRASGGPAEQTFATLVGLELRPRKMREAAAFWERLTQAAGVDTRDGIWQHPDLLPNAEDLDEPAGFIDRVIGGDTSGIDEAIAKLEREDPDSDGPVDN
>NZ_CP012885.2|WP_009955776.1|4647642_4648665_-|PDZ-domain-containing-protein
MNRRILTLMVALVPIVVFGVLLAVVTVPFVSLGPGPTFDTLGEVDGKQVVAIQGTLTHPTTGHLNMTTVSQRDDLTLGEALTLWLSDTEQLVPRDIIYPPGKSREEVDKANSADFKQSEDSAEYAALGYLKYPSAVTVAKVPEPGPSAGKLKAGDAIDAVNGTPVATVDAFTGLLKNTKPGQTVTIDYRRKNEPAGVAQITLGSNKDRDYGYLGVAVLDAPWAPFVVDFNLANIGGPSAGLMFSLAVVDKLTTGGLAGSNFIAGTGTITADGKVGQIGGITHKMVAAHAAGATVFLVPAKNCYEASSDNPSGLRLVKVETLSQAVDALHAITSGGQPPSC
>NZ_CP012885.2|WP_026071234.1|4644590_4647569_-|UPF0182-family-protein
MGMRPTARMPKLTRRSRILILIALGVIALLLAGPRLIDAYVDWLWFGELGYRSVFSTVLVTRFVVFLIAGLLVGGIVFAGLAVAYRTRPVFVPSNDNDPVARYRALVLSRLRLVSAGVPVAIGLLAGIIAQSYWVRIQLFLHGGDFGIKDPQFGKDLGFYAFELPFYRLLLSYLFVAVFLAFVANLLAHYIFGGIRLSGRTGALSRSARIQLVTLVGLLVLLKAVAYWLDRYELLSHTRGGKPFTGAGYTDINAVLPAKLILMAIALICAGAVFSAVVLRDLRIPAIGLVLLLLSSLIVGAGWPLIVEQISVKPNAAQKESEYISRSIAATRQAYGLTADVVTYRNYTGDAQATAQQVADDRATTSNIRLLDPTIVSPAFTQFQQGKNFYYFPDQLSIDRYLDRNGSLRDYVVAARELNPDRLIDNQRDWINRHSVYTHGNGFIASPANTVRGIANDPNQNGGYPEFLVNVVGANGNVVSDGPAPLDQPRVYYGPVISNTAADYAIVGRNGADREYDYETSNETKNYTYTGLGGVPLGDWLSRSVFAAKFAERNFLFSNVIGSNSKILFNRDPARRVEAVAPWLTTDSAVYPAIVNKRLVWIIDGYTTLDNYPYSELTSLESATADSNEVAFNRLAPDKRVSYIRNSVKATVDAYDGTVSLYQQDEQDPVLKAWMRVFPGTVKPKSDITPELAEHLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPTASSYQPPYYIVAKNIAKNDNSSSYQLTSAMNRFKRDYLAAYISASSDPATYGRITVLTIPGQVNGPKLANNAITTDPAVSQDLGVIGRDNQNRIRWGNLLTLPVGQGGLLYVEPVYASPGASDAASSYPRLIRVAMMYNDKIGYGPTVRDALTGLFGPGAGAAATGIQPTEAGTPANPPPSAPAPAATPGSPPPAAVPPAPDGSVALSPAKAAVLQEIQAAIGAAKDAQKKGDFAGYGAALQRLDDAITKYNNTK
>NZ_CP012885.2|WP_173662738.1|4643606_4644587_+|DJ-1/PfpI-family-protein
MADVAHEGKHSRVVVIVVFDGVTLLDVAGAGEVFVEANRFGADYRLKIASVDGRLRRRLPAQDRVGGRPRRDIDSADIVVVAGSDHLPGRPIDPALVEAVRSVAARTGRMASICTGSFILAQAGLLDGRRATTHWHDARLLARAFRDVTVEPDAIFVRDGDVFTSAGISSGIDLALALVEMDHGTELVRDVARWLVVYLKRAGGQSQFSVLVEADPPPQSPLRAVTEAVAADPGADYSVKKLAALASLSTRQLTRLFQSELGMTPARYVELVRVDFARNALEAGRSVTETAGMAGFGSIETLRRAFVNHLGISPKAYRDRFRTAYA
>NZ_CP012885.2|WP_042913107.1|4642854_4643505_-|HD-domain-containing-protein
MTTSSIDAIAGIHVPDTALAREVTEFIRDTEDELLFNHSRRVYFFGALQGLRRGVQPNLELLYVAAMFHDVGLTEHYRNSTVRFEVDGANAARDFLMDAGADQADADTVWLGIALHTTPGVPEFLAPEVALLQAGVEVDVVGVGREQLAPEALAAVTAAHPRPQFKQRILAAFNDGMKHRPRTTDGTMNADVLAHFDPTFGRVDFVDKILHNSWPE
>NZ_CP012885.2|WP_042913114.1|4655506_4655761_+|mycoredoxin-Mrx1
MTTAPLTVYTTSWCGYCHRLMTVLKSNGIPYEAVDIEHDAAAADFVSSVNGGNRTVPTVKFADGSTLTNPSAAQVKAKLTETGS
>NZ_CP012885.2|WP_014712227.1|4655772_4656705_-|NAD(+)-diphosphatase
MAIADFQLRSVPLLSRVGADRADQLRTDVEAATAGWADAALLRVDSRNQVLVSDGRVVLGAAAELGDKPPSEAVFLGRLEGGRHVWAIRGALQAPEDPDARTEVVNLRSLGPIFDDTSGQLMSSAVALLNWHEKSRFSSVDGSPTRPARAGWSRVNPVTGHEEFPRIDPAVICLVHDGGDRAVLARQAVWPERMFSLLAGFVEAGESFEGCVAREIREEIGLTVRDVRYLGSQPWPFPRSLMVGFHAVGDPAQDFSFNDGEIAEAAWFTRDEVREALAAGDWSSSSESKLLLPGSISIARVIIESWAAID
>NZ_CP012885.2|WP_008259653.1|4656704_4657775_-|potassium-channel-family-protein
MGNGRSRKLSGLDETLTAQRGHQLIGVVRIPEEHASPIRVITRRLAIALVVLFGAAVIVYLDRDGFRDVRNEPLTFLDCLYFSAVSLSTTGYGDITPYTETARLVHTLIFTALRIAFLAVLVGTTLEVLSERSRQGWKIQRWRSRVRNHTIVIGYGTKGKTAVAAILGDETIQAEVVVVDTDRSTLEHAESAGLVTVHGDATKADVLRLAGAQHAASIIVATSRDDTAVLATLTAREIAPNAKIVASIREAENQHLLQQSGADSVVVSSATAGRLLGLATTTPSVVEMIEDLLTPDAGLAIAEREVEQSEVGGSPRHLRDIVLGVVRDGHLWRIDAPEVDAVEANDRLLYIRSVGH
>NZ_CP012885.2|WP_072501415.1|4661167_4664293_-|ATP-dependent-helicase
MAHTWEADASAVLAPGARGIVRVLGGPGTGKSSLLIDAAVAGIDAGIDPESVLLLTGSGRLGMAERSALTTALLRSRPGRVAVSEPLVRTVHGYAYAVLRRAAERAGDAPPRLVTSAEQDAIIRELLAGDLDDGARATSAWPAQLRPALSTAGFATELRNLLARCAERGIDPGELERLGRHCRRPEWIAAGQFARQYEQVMLLRAAVGTAAPEATTPALGAAELVGAALEAFAVDPELLAAERGRIRVLLVDDAQQLDPQAARLVRVLAAGAELALIAGDPNQAVFGFRGGEPAGLLDGDGPAVTLTTSHRCAPAVARAVSGIAARLPGGGAGRRIDGAGAGEGSVTVRLAASAHAEAAAIADALRRAHLVDGVPWSQMAVIVRSVPRAGPRLPRALAAAGVPVAAAAATGPLAEEPAVRALLTVLLAAADGLDGQQACGNCAEPCSAPTPIARRQLRRTLQRANPDRPPGDFAELLVETLSGAVPPGPQFRSLRKVRAVLDAAARCHEAGEDPRYTLWDAWHRSGLQRRWLSVSERGGPAAAQATRDLESVTALFDITDDYVSRTSGASLRGLVEHVAALHLPNANLEPAATAGQVRVLSAHAAMGHEWDFVVIAGLQDGLWPNTVPRGGVLGTQRLLDELDGVTADASMRAPLVAEERRLLVAAMGRARRRLLVTAVDSDTGGADHAAALPSPFFFDIAQWADEDVETTALQPVSAPRVLSAAALVGRLRGVVCAPDGAVDELARDCAATQLARLAKAGVPGADPAGWHGLTPVSTGEPLRGGGDVVTLTPSTLQTLTDCPLRWLAERHGGTNPRDLRSTIGSVVHALIAEPRRSESELLAGLERAWQHLPFAAQWHSDNELARHRAMLEAFVEWRSQSRGALTEVGVEVEIDGTLQTGDGEQVRLRGRVDRLERDAAGRLVIVDVKTGKSPVSKDDAQQHAQLAMYQLAVAEGLVAAGGDTVEPGGARLVYVGKAGAAGAVEREQDPLTADAGDEWRQVIRRAAAATAGPQFVARRNDGCTHCPIRPCCPAHTDGAAR
>NZ_CP012885.2|WP_080691230.1|4664380_4664617_+|hypothetical-protein
MVSRLQKEGLTTMTDEHGFPTDEAPEGDAVEQLRPADSDDDAGLDTDYVSARDREANEADVIEQAYVVSADDERDDDR
>NZ_CP012885.2|WP_042913116.1|4664662_4665448_+|alpha/beta-hydrolase
MTAKLYVHRYGPSGPARILALHGLTGHGQRWQHLSGLLPEIGLAAPDLLGHGRSSWAAPWTIDANVSALAALLDAQAGTPVVVVGHSFGAGLAMHLAAARPNQVSGLLLLDPAIGLDGAWMREIAEAMLSSPDYPDAEEARLEKVHGSWSDVEPALLEAELDEHLVALPNGRYGWRISLPAMMAYWSELARDAVLPPAQTPTILVRAKRTSPPYVTDELIAGLAQRLGSRFRLLDFDCNHMVPYAKPDGVAALARELLGAR
>NZ_CP012885.2|WP_014712233.1|4665450_4665762_+|MGMT-family-protein
MAPVTDDQVERVRALVAAIPSGRVATYGDIASVAGLSSPRIVGWIMRTDSSDLPWHRVITASGRPARHLTTRQLELLRAEGVLARDGRIALREVRYEFPDGVL
>NZ_CP012885.2|WP_008259667.1|4665768_4666623_-|TIGR02569-family-protein
MTVEPPPDHVLSAFGLAGVKPVYLGASWEGGWRCGEVVLSLVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGTPEPRHDEVVSAAVRLHEATGKLERPRFLTQGPAAPWGDVDIFIAADRAAWEERPLASVPPGARVAPATADAERSVELLNQLATLRKPTKSPNQLVHGDLYGTVLFVGTAAPGITDITPYWRPASWAAGVAVIDALSWGEADDGLIERWNALPEWPQMLLRALMFRLAVHALHPRSTAEAFPGLARTAALVRLVL
>NZ_CP012885.2|WP_042913117.1|4666658_4667846_-|adenylyltransferase/sulfurtransferase-MoeZ
MLSVSSLPPLVAPADHLTGDEVARYSRHLIIPGLGVDGQKRLKNARVLVIGAGGLGAPTLLYLAAAGVGTIGIVEFDVVEESNLHRQIIHGVADVGRPKAVSARESMLAINPLVDVRLHEVRLDSTNAVELFGCYDLIVDGTDNFATRYLINDAAVLAKKPYVWGSIYQFEGQISVCWEDAPDGRGLNYRDLYPEPPPPGTVPSCAEGGVLGIVCASIASVMSTEVIKLITGIGDSLLGRLMIYDALQMTYRTIAIRRDPSDASRPKITELVDYEQLCGAAADTPVGDATTITPRELRELLDSGKELALIDVREPVEFDIVHIDGAQLVPQSSINSGEGLAKLPRDRMPVLYCKTGVRSAQALAVLKQAGFADAVHLEGGIVAWAQQMQPDMILY
>NZ_CP012885.2|WP_161807807.1|4667927_4668761_-|DUF3152-domain-containing-protein
MPVLAVLTAVVMYQTVTGAGASKPTNSQPIESPPAIGAVGTTIIDAPPRGLAAFDANLPAGTLPDGGPFTEAGDKTWHAVPGATPQFGQGTAKVFRYTVEVENGIDPTMFGDDEAFAQMVDQTLANPKGWTHNPQFAFIRIDGASGAKPDFRISLVSPVTVREGCGYEFRLETSCYNPVFGANREARVFINEARWVRGAVPFEGDIGSYRQYVINHEVGHAIGYLHHEACEQQGALAPVMMQQTFSTSNNDAAQFDPDTVKADGKTCRFNPWPYPIA

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Crispr_ID: NZ_CP012885_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012885_7

5487757-5487838

Orphan

Consensus_repeat	Method
GGCCAGCGACACCGCCGGCACGTGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012885_7

>merge|NZ_CP012885|7|5487757-5487838|CRISPRCasFinder
GGCCAGCGACACCGCCGGCACGTGCAGGTGTGTCCCGCTCGCCCAGTTGATCGCCAGGCCAGCGACACCGCCCGCACGTGCA

>NZ_CP012885|7|7|5487757-5487838|CRISPRCasFinder
GGCCAGCGACACCGCCGGCACGTGCA	GGTGTGTCCCGCTCGCCCAGTTGATCGCCA
GGCCAGCGACACCGCCCGCACGTGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012885.2\|WP_042913794.1\|5499221_5500478_+\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325
NZ_CP012885.2\|WP_042913781.1\|5483191_5483560_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NZ_CP012885.2\|WP_014383448.1\|5488861_5489506_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP012885.2\|WP_042913793.1\|5497594_5498599_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270276
NZ_CP012885.2\|WP_087139782.1\|5478766_5478931_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_072501454.1\|5491598_5495807_+\|DUF3367-domain-containing-protein	unknown	unknown	gnl\|CDD\|378735
NZ_CP012885.2\|WP_042913787.1\|5489844_5490996_-\|beta-glucosidase	unknown	unknown	gnl\|CDD\|366376
NZ_CP012885.2\|WP_007769006.1\|5491369_5491543_+\|DUF2613-domain-containing-protein	unknown	unknown	gnl\|CDD\|378543
NZ_CP012885.2\|WP_020823766.1\|5482659_5483130_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP012885.2\|WP_042913786.1\|5486710_5487562_+\|dehydratase	unknown	unknown	gnl\|CDD\|366711
NZ_CP012885.2\|WP_042913778.1\|5478949_5479438_-\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|214900
NZ_CP012885.2\|WP_042913782.1\|5483838_5485185_-\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|236440
NZ_CP012885.2\|WP_003874034.1\|5477894_5478641_+\|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|237086
NZ_CP012885.2\|WP_172417543.1\|5479518_5480577_-\|isopenicillin-N-synthase-family-oxygenase	unknown	unknown	gnl\|CDD\|226022
NZ_CP012885.2\|WP_042913779.1\|5480737_5482573_+\|acyl-CoA-dehydrogenase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|173842
NZ_CP012885.2\|WP_042913784.1\|5485336_5486701_+\|3-oxoacyl-ACP-reductase	unknown	unknown	gnl\|CDD\|236207
NZ_CP012885.2\|WP_042913791.1\|5495905_5497354_+\|lipase-maturation-factor-family-protein	unknown	unknown	gnl\|CDD\|369070
NZ_CP012885.2\|WP_042913788.1\|5491083_5491278_+\|DUF2613-family-protein	unknown	unknown	gnl\|CDD\|378543
NZ_CP012885.2\|WP_042913798.1\|5501883_5502234_+\|DUF732-domain-containing-protein	unknown	unknown	gnl\|CDD\|368380
NZ_CP012885.2\|WP_042913796.1\|5500492_5501863_+\|PPE-family-protein	unknown	unknown	gnl\|CDD\|366325

Protein	Function_ID	Function_description	E-value
NZ_CP012885.2\|WP_042913781.1\|5483191_5483560_+\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	5.23036e-09
NZ_CP012885.2\|WP_014383448.1\|5488861_5489506_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.8765e-15
NZ_CP012885.2\|WP_042913793.1\|5497594_5498599_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270276	cd13558, PBP2_SsuA_like_2, Putative substrate binding domain of sulfonate binding protein, the type 2 periplasmic binding protein fold. This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.31685e-94
NZ_CP012885.2\|WP_042913788.1\|5491083_5491278_+\|DUF2613-family-protein	gnl\|CDD\|378543	pfam11021, DUF2613, Protein of unknown function (DUF2613). This is a family of putative small secreted proteins expressed by Actinobacteria. The function is not known.	3.16743e-06
NZ_CP012885.2\|WP_072501454.1\|5491598_5495807_+\|DUF3367-domain-containing-protein	gnl\|CDD\|378735	pfam11847, DUF3367, Domain of unknown function (DUF3367). This domain is functionally uncharacterized. This domain is found in bacteria and archaea. This presumed domain is typically between 667 to 694 amino acids in length.	0
NZ_CP012885.2\|WP_042913794.1\|5499221_5500478_+\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.28019e-56
NZ_CP012885.2\|WP_007769006.1\|5491369_5491543_+\|DUF2613-domain-containing-protein	gnl\|CDD\|378543	pfam11021, DUF2613, Protein of unknown function (DUF2613). This is a family of putative small secreted proteins expressed by Actinobacteria. The function is not known.	1.36384e-14
NZ_CP012885.2\|WP_020823766.1\|5482659_5483130_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	8.56426e-17
NZ_CP012885.2\|WP_042913787.1\|5489844_5490996_-\|beta-glucosidase	gnl\|CDD\|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	2.41808e-85
NZ_CP012885.2\|WP_042913786.1\|5486710_5487562_+\|dehydratase	gnl\|CDD\|366711	pfam01575, MaoC_dehydratas, MaoC like domain. The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity. This domain is also present in the NodN nodulation protein N.	2.70487e-21
NZ_CP012885.2\|WP_042913782.1\|5483838_5485185_-\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|236440	PRK09268, PRK09268, acetyl-CoA C-acetyltransferase.	0
NZ_CP012885.2\|WP_003874034.1\|5477894_5478641_+\|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit	gnl\|CDD\|237086	PRK12386, PRK12386, fumarate reductase iron-sulfur subunit; Provisional.	0
NZ_CP012885.2\|WP_172417543.1\|5479518_5480577_-\|isopenicillin-N-synthase-family-oxygenase	gnl\|CDD\|226022	COG3491, PcbC, Isopenicillin N synthase and related dioxygenases [General function prediction only].	3.65385e-86
NZ_CP012885.2\|WP_042913779.1\|5480737_5482573_+\|acyl-CoA-dehydrogenase-C-terminal-domain-containing-protein	gnl\|CDD\|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	0
NZ_CP012885.2\|WP_042913784.1\|5485336_5486701_+\|3-oxoacyl-ACP-reductase	gnl\|CDD\|236207	PRK08261, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional.	0
NZ_CP012885.2\|WP_042913791.1\|5495905_5497354_+\|lipase-maturation-factor-family-protein	gnl\|CDD\|369070	pfam06762, LMF1, Lipase maturation factor. This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. The precise role of LMF1 in lipase folding has yet to be determined.	3.13669e-154
NZ_CP012885.2\|WP_042913778.1\|5478949_5479438_-\|flavin-reductase-family-protein	gnl\|CDD\|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	9.93978e-38
NZ_CP012885.2\|WP_042913798.1\|5501883_5502234_+\|DUF732-domain-containing-protein	gnl\|CDD\|368380	pfam05305, DUF732, Protein of unknown function (DUF732). This family consists of several uncharacterized Mycobacterium tuberculosis and leprae proteins of unknown function.	4.5949e-22
NZ_CP012885.2\|WP_042913796.1\|5500492_5501863_+\|PPE-family-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	7.21219e-56

>NZ_CP012885.2|WP_042913786.1|5486710_5487562_+|dehydratase
MNQPSGLKNLLRAAAGALPVVSRGGGLPTRTVTIEELPIDRTNVAEYAAVTGLRYGNCVPLTYPFALTFPALMSLVTGFDFPFAAMGSVHTENHITQYRPIAVTDTVGVHVHAENLREHRKGLLVDLVTDVSVGGNSQDTAWHQVTTFLHQQRTSLSDEPKPPPQKQPKLPPPPTVLRISPGLIRRYAVVGGDHNPIHTNPIAAKLFGFPTVIAHGMFSAAAVLANIEAAIPDAARYSVRFGKPLVLPATAGLYIDENADGWDLSLRNIAKGYPHLTGTVRPL
>NZ_CP012885.2|WP_042913784.1|5485336_5486701_+|3-oxoacyl-ACP-reductase
MAPKVSSDLFSQIVNSGPGSFLAKQLGVPQPETLRRYRAGDPPLAGALLIGGEGRVVEPLRAALDADYDLVGNNLGGRWADKFGGLVFDATGITTPEGLKGLHEFFTPLLRNLGHSARVAVVGTTPDGAASPHERIAQRALEGFTRSLGKELRNGSTVALVYLSPDAKPAATGLESTMRFILSAKSAYVDGQVFYVGEADSTPPGDWERPLDGKVAIVTGAARGIGATIAEVFARDGARVVAIDVESAAEALAETASRVGGTALWLDVTAPDAVDKITEHLREHHGGHADVLVNNAGITRDKLLANMDDARWDAVLAVNLLAPLRLTEGLVGNGSIGEGGRVIGLSSMAGIAGNRGQTNYATTKAGMIGLTQALAPELYDKGITINAVAPGFIETQMTAAIPLATREVGRRMNSLLQGGQPVDVAEAIAYFASPASNAVTGNVIRVCGQAMLGA
>NZ_CP012885.2|WP_042913782.1|5483838_5485185_-|acetyl-CoA-C-acetyltransferase
MAPASSEASTPAAQRSSERRRVAILGGNRIPFARSDGAYAEASNQDMFTAALGGLVDRFGLAGERLGVVVGGAVLKHSRDFNLTRECVLGSQLASYTPAFDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDAPIGLGDNLRRTLLKLRRAKSNVQRLKLVGTLPATLGVEIPVNSEPRTGLSMGEHQAITAKQMGISRVAQDELAAASHRNMAAAYDRGFFDDLVTPFLGLYRDDNLRADSSAEKLAKLRPVFGVKAGDATMTAGNSTPLTDGASVALLGTDEWAEAHSLTPLAYLVDSETAAVDYVNGRDGLLMAPTYAVPRLLARNGLSLQDFDFYEIHEAFASVVLCHLQAWESEEYCKGRLGLDAALGSIDRSKLNVNGSSLAAGHPFAATGGRILAQAAKQLAQRKAEQKGAGKPVRALVSICAAGGQGVAAILQA
>NZ_CP012885.2|WP_042913781.1|5483191_5483560_+|VOC-family-protein
MAATGPDFISLQARDLDASQAFYEQYLGLVRSPAGPPHAVVFETKPIAFALREVAPGTDLASMAQPGIGAAIWVHATDVQSIHDALVADGHTIVSAPIDGPFGRTFTFADPDGYYVTLHDRT
>NZ_CP012885.2|WP_020823766.1|5482659_5483130_-|MarR-family-transcriptional-regulator
MSQEGVGVDLDTSLGYALKEASSALRAAMEEVLRPLGMSVTHYSCLELLAQRPGLSNSELARGAFVTRQSMNVLLQALERDGYVARPAEAPVGKILPTRLTPRGRQSLEKASKAVRSVEVRMLAGLTEAERSDAFRILHSMTRSLRDGPGRSAPER
>NZ_CP012885.2|WP_042913779.1|5480737_5482573_+|acyl-CoA-dehydrogenase-C-terminal-domain-containing-protein
MSHYKSNVRDQAFNLFEVLGVDKALGQGEYSDLDADTAREMLNEISRLAEGPVADSFVEGDRNPPVFDPKTHSVTLPESFKKSVQAVIEAGWDKVGLDEALGGVPAPKALLWALHEHLLGANPAVWMYAGGAGFAQILHHLGTEEQKKWAELAAERGWGSTMVLTEPDAGSDVGAGRTKAVQQEDGSWHIDGVKRFITSADSGDLFENIFHLVLARPEGAGPGTKGLSLFFVPKFLFDFETGELGERNGVYVTNVEHKMGLKVSATCELSFGQHDVPAKGWLVGEVHNGIAQMFEVIEQARMMVGTKAIATLSTGYLNALEYAKSRVQGADMTQMTDKTAPRVTITHHPDVRRSLMTQKAYAEGLRALYLFTATYQDSAVAEALHGVDAELAVKVNDLMLPVVKGVGSEQAYAKLTESLQTFGGSGFLQDYPIEQYIRDAKIDSLYEGTTAIQAQDFFFRKIVRDKGVALAHVSEQIQKFVDSESGNGRLKTEREYLAKALTDVQAMATSLTGYLMAAQEDVTSLYKVGLGSVRFLMSVGDLVIGWLLQRQAAVAVAALDAGASGDDKAFYEGKVAVASFFAKNFLPMLTSTREVIETLDNDIMELDEAAF
>NZ_CP012885.2|WP_172417543.1|5479518_5480577_-|isopenicillin-N-synthase-family-oxygenase
MPPKTGSTCGDGSGTAGVRGVTAVPVVDLRDDPGRLRDGLREAGHRVGFFYLTGHGVPPELVMRVLEAARRLFALPQQHKDAVAMANSPHFRGYTRLGGEVTRGEVDWREQIDIGPQRAPIGGLGKSDYRWLQGPNQWPAALPELPGIVEEWDAALSAVARTLLRHWAASLGSPADVFDPAFAETPATLIKIIRYPGRAAGSQGVGAHRDAGMLTLLLAEPGSQGLQVRRAFDGAWVDVPPREGAFIVNIGELLEAATRGYLRATEHRVDLHGPARDRISVPYFFNPRLDARLPVLSLPAELRAVSSDWSAAQDPADPIFSVYGRNAWKSRLRSHPDVASAHGYSAERLENG
>NZ_CP012885.2|WP_042913778.1|5478949_5479438_-|flavin-reductase-family-protein
MNSNNKLTASSLREAFGHFPSGVVAIAAEVNGTREGLAASTFVPVSLDPPLVSFCVQNTSTTWPKLKDLPMLGISVLGEAHDEAARTLAAKTGDRFAGLETVSRSTGAVFIKGTGLWLESAIEQLIPAGDHTIVVLRVSEVTVDADVAPIVFHRSNFRRLGA
>NZ_CP012885.2|WP_087139782.1|5478766_5478931_+|hypothetical-protein
MEPRRETASINNIRTAIRQLSVRAQLAQKEGRHNDAAELERRIQGFREELSHRP
>NZ_CP012885.2|WP_003874034.1|5477894_5478641_+|succinate-dehydrogenase/fumarate-reductase-iron-sulfur-subunit
MTYNATMRVWRGDDANGALQDFTVEVNEGEVVLDIIHRLQQTQTPDLAVRWNCKAGKCGSCSAEINGYPRLLCMTRMSTFAEDEVVTVTPLRTFPVIRDLVTDVSFNYEKAREIPSFAPPKDLQPGEYRMAQEDVQRSQEFRKCIECFLCQNVCHVVRDHEENKKAFAGPRFLMRIAELEMHPLDTRDRRKDAQEEHGLGYCNITKCCTEVCPENIKITDNALIPMKERVADRKYDPVVWLGNKLFRR
>NZ_CP012885.2|WP_014383448.1|5488861_5489506_-|TetR/AcrR-family-transcriptional-regulator
MAGGTKRLPRAVREQQMLDAAVQMFSVNGYHETSMDAIAAEAQISKPMLYLYYGSKEDLFGACLNREMTRFIDVLRADIDFRQSPNDMLRNTIASFMRYIDANRASWIVMYTQATSSQAFAHMVREGREQIIDLVAGLMRAGSRAPRPDIEHEMMAVALVGAGEAVANRLSTGDIDVDEAAQLMIDLFWYGLKGSPEEREAARSQPDGSDAAGD
>NZ_CP012885.2|WP_042913787.1|5489844_5490996_-|beta-glucosidase
MAFSRTFAVLAAASALVAGCGHHPAPPAHSSTSSKPAAAPAPPVCADPAAVPAALGIRDKLAQLLMVGVKNADDARAVVNGYHVGGIFIGSWTDLTIFQGPLADISAKAGPLPLAVSVDEEGGRVSRLKTLIGTSPPARELAQTHTVQQVHDLAADRGRKMRDLGITVDFAPVVDVSDEDDDAVIGNRSFGADPQTVTDYAGAYAQGLRDAGLLPVLKHFPGHGHGSGDSHTGGVVTPPLADLQTSDLVPYRSLVAAAPVAVMVGHLQVPGLTGDVPASLSPEAVQLLRNGVGYKGPPFTGPVFSDDLSSMAAISDRYGVSEAVLRSLLAGVDVALWVTTDEVPAVLDRLQKAVASGELPARRVDEALVRVAKMKGPGPTCGH
>NZ_CP012885.2|WP_042913788.1|5491083_5491278_+|DUF2613-family-protein
MSGFTVAAAASIAAGLAVGIATTVGITLAVADDTAVPAQAPVRPALPYQVQYGDRCFHGHCLHW
>NZ_CP012885.2|WP_007769006.1|5491369_5491543_+|DUF2613-domain-containing-protein
MNRIVAPAAASVVVGLLLGAAAIFGITLMVQQDTKPPLPGGDPQSSVLNRVEYGNRS
>NZ_CP012885.2|WP_072501454.1|5491598_5495807_+|DUF3367-domain-containing-protein
MSRRWLWLVGAIALALTFAQSPGRISPDTKLDLTANPLRFLARATNLWNSELPFGQAQNQAYGYLFPHGTFFLIGHALGVPGWITQRLWWALLLTAGFWGLMRVAEAMRIGSPASRVIAAVAFALSPRVLTTLGSISSETLPMMLAPWVLLPTILALRASTDRSVRALAARAGLAVALMGAVNAIATLAGCLPAVIWWACHRPNRRWWRYTGWWLLALLLATLWWVVALVMLRAISPPFLDFIESSGVTTQWSSLTEMLRGTDSWTPYVAPNATAGAPLVTGSAAILGTCLVAAAGLAGLASAAMPARGRLVTMLLVGAVLMAVGYSGGLGSPVAHAVQAFLDAGGAPLRNVHKLGSVIGIPVALGIAHLLGRIPLPGAAPTPVWLRAFAHPERDRRVAAAMVVLTALMVSTSLAWTGRLAPPGTFTAIPPYWHEAADWLTEHNTGAPTPGRVLVVPGAPFATQVWGTSHDEPLQVLGSSPWGVRDSIPLTPPQTIRALDSVQRLFAAGRPSAGLADTLARQGISYLVVRNDLDPDTSRSARPILVHRAVDGSPGLRKVAQFGAPVGPGTLAGFVADSGLRPRYPAVEIYRVAGGGDVSDPATPYLVDADRLARVDGGPEALLRLDERRRLLGQPPLGPALLTADAGAAGLPLPPGAGVTVTDTPVARETDYGRVDQHSSAIRAPGDARHTYNRVPDYPVPGAEPVAGAWTGGCRTIPSPSSDSTAMPDVAPATSPAARRRIPPPCPTSSNSLQAAIGQWMRIDFDHPVTNAAITLTPSATAVGAQVRRILIETATGSTTLRFDEAGKPLAAALPYGETPWVRITAAGTDDGSAGVQFGITDLTITQYDASGFAHQVDLRHTVRVPGPPPGAPIAGWDLGSELLGRPGCAPAPDTVRCAPSMALTPEEPVNFSRTLTVPAPVSVTPTVWVRPRQGPKLAALIAEPNATVAQGDSDAVDVLGSAYAATDGDPATAWTSPQRVVQHKTPPTLTLRLPRPTEVTGLRLVPSRAALPVRPTMVAVNLGDGPQVAAVKADSGAAQTLTLKPRVTDTVTLSLLDWDDVIDRNALGFDQLKPPGLAEVAALGADGNAIAPADAARNRGREISLGCDRGPVIAVAGRFVHTAIHTTVGAILDDQPLAAVPCDRDPIALPAGDQELLISPGAQFVVDGAQLSTSGAPESARAERLSSWRAWGPARREVQAPPSATPRVMVIPESINPGWVARTGSGARLTPIAVNGWQQGWVVPAGDPGTITVTFASNPLYRAGLAVGLALLPLLALLAFWRTRTRDADAPTQPWRPGPWAAVPALAAGALIAGAGGVVVMGAALGLRYALRARRWERLALVGSAGGLILAGAALSRQPWRSADGYAGHSANVQLLALVSLAVLTASVIVLPDRERRPGDE
>NZ_CP012885.2|WP_042913791.1|5495905_5497354_+|lipase-maturation-factor-family-protein
MSWFSAPEYWVGRLVLERGAAAIYLLAFVAAAAQFRALIGEHGMLPIPRFVAAQSFWRTPSIFHLRYSDRLFAAVAWFGAALSAAVVAGAADAVPLWAAMAMWLVLWVLYLSIVNVGQTWYSFGWESLLLETGFLMIFLGNNDVAPPVLTLWMVRLLLFRVEFGAGLIKMRGDPCWRDLTCLYYHHETQPMPGPLSWFFHHLPKPLHRVEVAGNHFAQLIVPFGLFAPQPVASVAAAIIVITQLWLVASGNFAWLNWVTILLACSAIDDASVASLLPGTLVPAHDGPAAPAWFVVLVAAVSAAVLFMSYWPIRNMLSSRQRMNMSFNSFHLVNTYGAFGSIGRIRREVVIEGTDDDQLSDQTVWREYEFKGKPGGPRRLPRQWAPYHLRLDWLMWFAAISPGYAQPWLRPFLQRLLRNDRPTLRLLRHNPFPDAPPRFVRAQLYQYRFTTPAELRRDRAWWHRALVGGYAPPMTLSTPTTTN
>NZ_CP012885.2|WP_042913793.1|5497594_5498599_+|ABC-transporter-substrate-binding-protein
MSTRRHTALLLAAIALALPACVSRQQAAGPGAVPDRVPLSQLADLTLRVGDQKSVGTEAMLRAAGELQNVPYRIEFSTFTSGPPMVEAAAAGKIDFAITGDTPPIFGAVANARIKVVSAFDGGGPGDQILVHVDSPIHSVTDLRGKTIALAKGSSAHANVLDQLDKAGLKPNDVHLVFLQPADALSGFRNGQVDAWAVWDPYTAQAEQQLPVRGLVTRKYKYSFGIASDQTLADAKRNTALADLLARYTRAAVWAREHPQEWAAQYAGSAGIDPAVAAVAQGRTLRQPIPLDDTVIDAEQRLTDLLAAAGQIKSAPRFGNWVDRRFTATAAETH
>NZ_CP012885.2|WP_042913794.1|5499221_5500478_+|PPE-family-protein
MEFGALPPEINSGRIYSGPGPAPLLAAAAAWDGLASELRVTAASYGSVVAELRTAWNGPSSTSMAAAAAPYVAWLIGSAAQAEQSASQAKAAAGAYEAVFAATVPPPVIAANRALLATLVATNILGQNTPAIATTEAQYAEMWAQDAAAMYGYAGSSAAATQLAPFTTPPTTTDSSAETNQAAAVAAAAQSSASSNVESAVSQALSQAPAAAQSAAAATTSPGISLGLGEATGGLKSFNSFLSTLTGPYSPLGVADAGKGFYQLALNTKAMGGNVQSVDPTLHPKGLHGVLAPLLHSDLLTGSTSFQPPGAGTVSAAVGRAGVVGSLSVPANWASAAPAIRTLAAELPETMLDAAPAMAVNPGQGLFGPTALSSLAGRAVGGSATRAVAGPAVRVAGAVAVDDIATTSTVIVIPPNPK
>NZ_CP012885.2|WP_042913796.1|5500492_5501863_+|PPE-family-protein
MVFTDFAALPPEVISIQLYAGPGAAPMLSAAAAWQALAAELHSTASSYGAAISELIGEDWQGPSSASMASAAAPYVNWISTTAVQAEQTAAQAQAAASAYEAALASVVPPALIAANRTQLAALQATNLLGQNGAAIAATEAEYAQMWSQDVTAMFGYAAASQSAGELAPFEQAPAVSKDTGSAAQASTTAAAASSSSSSWMQQLQDYINSLTTGYTQSWQKLIEGMTGSKEVAPLWEALFSSVKGVGGQATWTNVVGASGGLGVSEWKGAFVYAPWSAGLPKASLGAGLASPGGLGAGVPVRPVSAVLGTAPTVGKLSVPSSWATAAPAIRLASTALPATSAAAAAAAGFPAELVNDATLGSLAGGALGGPAARVLNTTTAIQTRAITGQRRTQPVKLDRIIAQLQEMPDQVQHWNVDEAGLDDLVAQLRTTPGVHAVHVNDEPTPAAAHPESQLG
>NZ_CP012885.2|WP_042913798.1|5501883_5502234_+|DUF732-domain-containing-protein
MTRLLALLTVSLGITIAAPAHATPGEDEAPADDNNGSFLSDLHTVGISFKDPGQAVAAGKSVCGMITRGVSGLQLLTDIRDNNPALTTSGAAQFATISAKAYCPGQLEESKGKGGG

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Crispr_ID: NZ_CP012885_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012885_8

5553961-5554046

Orphan

Consensus_repeat	Method
CGAGGCCGCCGAACGCAGGTGCACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012885_8

>merge|NZ_CP012885|8|5553961-5554046|CRISPRCasFinder
CGAGGCCGCCGAACGCAGGTGCACATGATGGTCGTGCAGCCCGGGCAGCACGGTTCCCCCACGAGGCCGCCGAACGCAGGTGCACA

>NZ_CP012885|8|8|5553961-5554046|CRISPRCasFinder
CGAGGCCGCCGAACGCAGGTGCACA	TGATGGTCGTGCAGCCCGGGCAGCACGGTTCCCCCA
CGAGGCCGCCGAACGCAGGTGCACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012885.2\|WP_042913847.1\|5557729_5558203_+\|CD225/dispanin-family-protein	unknown	unknown	gnl\|CDD\|377375
NZ_CP012885.2\|WP_172417602.1\|5546407_5547226_-\|crotonase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|181325
NZ_CP012885.2\|WP_042913836.1\|5545178_5545721_-\|isoprenylcysteine-carboxylmethyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224931
NZ_CP012885.2\|WP_042913846.1\|5555358_5556375_-\|acyl-dehydratase	unknown	unknown	gnl\|CDD\|239535
NZ_CP012885.2\|WP_086427142.1\|5548764_5549970_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NZ_CP012885.2\|WP_042913839.1\|5547310_5548720_-\|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	unknown	unknown	gnl\|CDD\|274360
NZ_CP012885.2\|WP_042913848.1\|5558245_5559187_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NZ_CP012885.2\|WP_008261874.1\|5561997_5563824_-\|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl\|CDD\|235256
NZ_CP012885.2\|WP_042913913.1\|5551028_5551757_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|131480
NZ_CP012885.2\|WP_042913841.1\|5550138_5550801_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|316372
NZ_CP012885.2\|WP_041298117.1\|5545820_5546411_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380054
NZ_CP012885.2\|WP_042913843.1\|5551931_5552831_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NZ_CP012885.2\|WP_042913832.1\|5543164_5543461_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_008261869.1\|5556498_5557644_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NZ_CP012885.2\|WP_042913849.1\|5565528_5566626_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_020823786.1\|5559190_5560720_-\|acyl-CoA-synthetase	unknown	unknown	gnl\|CDD\|236215
NZ_CP012885.2\|WP_014383463.1\|5560911_5561997_+\|sensor-domain-containing-diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP012885.2\|WP_042913834.1\|5543481_5544999_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|341228
NZ_CP012885.2\|WP_072501456.1\|5554145_5555336_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP012885.2\|WP_042913914.1\|5563963_5565532_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP012885.2\|WP_042913847.1\|5557729_5558203_+\|CD225/dispanin-family-protein	gnl\|CDD\|377375	pfam04505, CD225, Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.	4.29487e-27
NZ_CP012885.2\|WP_172417602.1\|5546407_5547226_-\|crotonase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|181325	PRK08252, PRK08252, crotonase/enoyl-CoA hydratase family protein.	2.35564e-151
NZ_CP012885.2\|WP_042913836.1\|5545178_5545721_-\|isoprenylcysteine-carboxylmethyltransferase-family-protein	gnl\|CDD\|224931	COG2020, STE14, Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones].	9.00966e-18
NZ_CP012885.2\|WP_042913846.1\|5555358_5556375_-\|acyl-dehydratase	gnl\|CDD\|239535	cd03451, FkbR2, FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The function of FkbR2 is unknown.	1.48286e-38
NZ_CP012885.2\|WP_086427142.1\|5548764_5549970_-\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	3.89811e-39
NZ_CP012885.2\|WP_042913839.1\|5547310_5548720_-\|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	gnl\|CDD\|274360	TIGR02946, Putative_diacyglycerol_O-acyltransferase_Mb3115, acyltransferase, WS/DGAT/MGAT. This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity].	8.21802e-163
NZ_CP012885.2\|WP_042913848.1\|5558245_5559187_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	5.44231e-45
NZ_CP012885.2\|WP_008261874.1\|5561997_5563824_-\|phosphoenolpyruvate-carboxykinase-(GTP)	gnl\|CDD\|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NZ_CP012885.2\|WP_042913913.1\|5551028_5551757_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	1.03497e-33
NZ_CP012885.2\|WP_042913841.1\|5550138_5550801_-\|SAM-dependent-methyltransferase	gnl\|CDD\|316372	pfam13847, Methyltransf_31, Methyltransferase domain. This family appears to have methyltransferase activity.	6.27676e-06
NZ_CP012885.2\|WP_041298117.1\|5545820_5546411_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|380054	pfam17920, TetR_C_16, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins found in Actinobacteria. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.	6.53314e-31
NZ_CP012885.2\|WP_042913843.1\|5551931_5552831_+\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	5.53231e-71
NZ_CP012885.2\|WP_008261869.1\|5556498_5557644_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	1.18034e-135
NZ_CP012885.2\|WP_020823786.1\|5559190_5560720_-\|acyl-CoA-synthetase	gnl\|CDD\|236215	PRK08276, PRK08276, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_CP012885.2\|WP_014383463.1\|5560911_5561997_+\|sensor-domain-containing-diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.37107e-44
NZ_CP012885.2\|WP_042913834.1\|5543481_5544999_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|341228	cd04433, AFD_class_I, Adenylate forming domain, Class I, also known as the ANL superfamily. This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.	4.81636e-116
NZ_CP012885.2\|WP_072501456.1\|5554145_5555336_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	9.26507e-25

>NZ_CP012885.2|WP_042913843.1|5551931_5552831_+|alpha/beta-hydrolase
MTNDAVHPDLQKLARFAPRRLVGPRTLPIMRAAMDWRARLGKPVRDVEVITLESGAGVRLFRPAGVSEPTPALLWIHGGGYVIGTAQQDDRLCSGFSRRLGITVASVEYRLAPEHPYPAPLEDCYAALTWLAGLPSVDRYRVAIGGASAGGGLAAGLALLARDRAEVSPSFQLLTYPMLDDRSSATAPSANYRLWDNRSNRFGWAAYLGNADPQVAVPARRDDLSGLPPAWIGVGTHDLFHDEDLAYAERLKAAGVPCEVEIVPGAFHGFDLIAPKLQVSQRFFDSQCDILRAALTPAS
>NZ_CP012885.2|WP_042913913.1|5551028_5551757_-|alpha/beta-fold-hydrolase
MWPSLLMTGDLWAGQAARFGDSHRLVLVDPPGHGGSAPLSGPFSFADCARCVVDLLDGLGIDRTHFVGNSWGGMIGGTFAALHPERLDRAVLMNCTASKAGVAQKIQYAAMLWLARLLGGIRPPLTQSSIRAFLGPTTLRTRPDVVEAVRTNVAAVNADSVRWAVRSVVSARPDQHALLARVTAPVLVVAGAEDATFPVAETRAMAESIPTASFTVLDGVAHLAALEDPARVNALLESFLFG
>NZ_CP012885.2|WP_042913841.1|5550138_5550801_-|SAM-dependent-methyltransferase
MLGQLYDRALGGERCWIRHDDGELRPLPAHRWLGVRCPPDGSGGSGDAVDEVFDEAVTQMCTGPTIELGCGPGRLVARLIQRGIPALGIDRSATAIQLAGRGGAPALLGDVFEELPGTGLWQTVLLVDGNVGLGGDPLRILARAFELLARGGRCIAEFEAETIGIRSRWVRLESSREVGPWFRWATVGVDSAAALAAQVGLTLTGVRLIGDRVIASLAAV
>NZ_CP012885.2|WP_086427142.1|5548764_5549970_-|alpha/beta-hydrolase
MTANRPGFTPWMKWLLRAGPADYALALSVAGASLPVVGKHLEPLAGITAMGVWGARHAPEAISAATKDWFTPGINDARRRDRESTRQVSLAALRGVVSAADLEMDWPAAERTPPIWDGLRQRRHLYRRGVHYGDHPAQVLDVWRRKDLPAQPAPVLIFLPGGAWVHGRCMGQGSALMSRLAEQGWVCLAVDYRVAPHHRWPRHIVDVKTAIAWARANVDKFGGDRNFVAIAGCSAGGHLCALAGLTPDDPEYRAKLPEGADTSVDAVVGIYGRYDWEDRSTPERARFVEFLERVVVRKSIARHPEVFRAASPIARVHRNAPPFLVIHGSKDSVIPVEQARSFVERLRTVSHSTVGYLELPGAGHGYDLIDGERAGAAAHVASLFLNQVYRTKTRIGAKEVI
>NZ_CP012885.2|WP_042913839.1|5547310_5548720_-|wax-ester/triacylglycerol-synthase-family-O-acyltransferase
MKRLSGWDSVLLYSETPNVHMHTIKAAVIELDVDRRSLDVDAFRQVIAGRLNKLDPFCYQLIEVPLNFHHPMWRENCEVDLDYHIRPWRVSPPGGRRELDEAIGQIASTALDRGRPLWEMYFVEGLANNRIAVVGKIHHALADGVASANLLARGMDLQPCPDGGPYMCDPPPTTRQLVASALADHVRHVGRLPHTIRYTAQGLGRVRRSTRKFSPELTRPFEPPPTFMNHKLTPERRFATATLALADVKETGKRLGATINDMVLAMSTGALRTLLLRYDGKAEPLLASVPMSFDFSPERISGNRFTGVLVGLPTDSDDPLERVRCSHENAIVAKESNQLMGPELVSRWAAYMPPGPTQAFFRWASGRDGHNKILNLNISNVPGPRERGRVGGALVTEIYSVGPLTAGSGLNITVWSYVDQLNISVLADGATCEDPHEVTDAMVNDFIEIRRAAGLSEKLTTIEAAMAPA
>NZ_CP012885.2|WP_172417602.1|5546407_5547226_-|crotonase/enoyl-CoA-hydratase-family-protein
MGPTSQQRDEQGSTVSEEANEPEVLVEQRDRILIITINRPKAKNAVNSAVANGLAAAVDRLDDEPGLSVGILTGAGGSFCAGMDLKAFARGELPIVEGRGMGFTERPPVKPLIAAVEGYALAGGTELALATDLIVASKDSAFGIPEVKRGLVAGGGGLLRLPQRIPSAIAMELALTGENLSAERAHALGMVNVLAEPGSALDAAIELAEKIAANGPLAVAATKQIIVESRGWSPETMFAEQNKLLAPVFSSNDAKEGAIAFAEKRPPKWTGT
>NZ_CP012885.2|WP_041298117.1|5545820_5546411_+|TetR-family-transcriptional-regulator
MPAARRAGRWRTGQVNRQRIIEAARERFMRDGYERATVRAIAADAGVDVAMVYYFFGNKEGLFTASTLTGPEHPLHQLATLLDEGTERVGERLARRFLEHWEQGAVFEPFLTLWRSAAIHPEARKVLHDSLAGPIAERVATEFGVADAELRVELVASHLAGLAFARYQLKIEPLASTSIEDLVGRLGPTLQRYLTD
>NZ_CP012885.2|WP_042913836.1|5545178_5545721_-|isoprenylcysteine-carboxylmethyltransferase-family-protein
MVTRTRRRLWWRHLMSVLLFPATMTLVVPALIIGTAGVREPRLDAAPTIALITVGCVLIAAGLALMIWTNVLFDRVGEGTLGLGNVMGEPVHLVVRGPYRHVRNPMITGVLCILLGEAAIIASGPLLLWFAIFFTFQAIAIRFWEEPHLADRYGREYVDYRSNVPRWIPRVSAWDPPARS
>NZ_CP012885.2|WP_042913834.1|5543481_5544999_-|long-chain-fatty-acid--CoA-ligase
MSISLLLEMAVSGDADRTAVVSGDLRLTTQQLSDLADGGAGVVAASGAKHLVYVGTGGAMLPVLIFAAARAGVAFTPINYRLSAEGIQALIERLPEPLVVVDGRYREMIGGVSDRVMVSDDFLDAARGAEPAAEFPDPDAVAIVLFTSGTTSQPKAVELSHNNLTSYVTGTVEFGAAADTDAALICVPPYHIAGVSAALSNLYAGRKMVYLPNFDAQEWVRLINTENVTTATVVPTMLDRIVTVLENGDGPAIELPSLRNLAYGGSKVGLPLVRRALELLPDVGFVNAYGLTETSSTIAVLTPDDHRAALAASTPEGARRLGSVGQAVAGIELQIRDEAGNVLPPGETGELFVRGEQVSGRYTGIGSVLDENGWFPTKDIAMLDDEGYLFIGGRSDDTIIRGGENIAPAELEEVLVEHPHVRDVAVVGVEDPQWGQAIVAVVVPAPGVDPDPAELREFVRKSLRGSRTPDEVVFRDELPTTATGKVLRREIIQTLTELRSAPAQQ
>NZ_CP012885.2|WP_042913832.1|5543164_5543461_-|hypothetical-protein
MIKNGTRLASQVCDTQVIVVRSADSLDDLRCGGAPMVPVGAERSGQLDPAFSDGTVMGKRYVDESGAEVLVTKPGAGSLSIGRTALHLKEVKPLPASD
>NZ_CP012885.2|WP_072501456.1|5554145_5555336_-|CoA-transferase
MGGVSSAATAWGSSGLAYLTGPPDGPADFSRARVLSRAHEVAAAIGGRWGIDVDAAGLLTGRAALRGMTRAGRVSPGGATRLLAARDGWCALTLSRADDLAAVPALLQVDDAAVDPWPQLRRWAATRPVPDIVERAALLDIPAAGLGEATAAPSHTRRIGPPAPPRAPRGLLVADLSSMWAGPLCGRLLAHAGATVVKVESPRRPDGTRAGDRTFFDWMNHEKLCYGIDFDSQTDELRELLTVSDVVIEGSRPAGLARRGLGPDDVAPRPGRIWLQITAYDGRRPGFGDDAAVGGGLVGTSAEGPVFCGDAIADPLTGLQAARTVAESLARGGGELIRLRRCAVAVRRRRRPTGPSESPAPVSPPPTPPATPPASGLGADNAAVRHLVGQRRCPSC
>NZ_CP012885.2|WP_042913846.1|5555358_5556375_-|acyl-dehydratase
MTSDGYARIREGGPYFDDLSVGQVFDWAPSMTLSSGLAGAHQAIVGDRLRLALDADLCGAVTGLPAPLAHPGLVCDVAIGQSTLVTQRVKANLFYRGLVFHRFPVIGDSLYTRTEVVGLRANSPKPGRAPTGLVALRMITIDQADQLVLDFYRCGMLPAGPDFDADNAPHDDLSTIGADVPGPAHDPTAQWDGEVFRTKVPGPHFDPALAGSVLHSTADVVTNAPELARLTLNIAATHHDSRVGGRRLVYGGHTIGLALAQAGRLLPNLVTVLGWESCDHTGPVHEGDTLYSELHIESAEPTEHGGVLGLRSLVYAAGDADGGPDRPVLDWRFRALQF
>NZ_CP012885.2|WP_008261869.1|5556498_5557644_+|acyl-CoA-dehydrogenase-family-protein
MNDEEDMLVATVRAFIDREVKPSVRETEHANTYPEAWIEQMKRIGIYGLAVPEEYGGSPVSMPCYVRVTEELARGWMSLAGAMGGHTVVAKLLTLFGTEEQKRTYLPPMAGGEVRATMALTEPGGGSDLQNMATTALSDDAGGLVINGSKTWISNARRSGLIALLCKTDPNAKPRHTGISIVLVEHGPGLTVSRDLPKLGYKGVESCELSFDNYRVPETAILGGVAGEGFSQMMKGLETGRIQVAARALGVATAALEDALAYAQQRESFGQPIWQHQSVGNYLADMATKLTAARQLTRYAAERYDSGERCDMEAGMAKLFASEVAMEIALNAVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIARQLVTRGGI
>NZ_CP012885.2|WP_042913847.1|5557729_5558203_+|CD225/dispanin-family-protein
MSYPPAPPGGSPEWPGQQPEWQGQQPEWQGQPPPGYQAQQPPGWPGQPPAGWPAPQPGWPGQPEPENYLVWAILCTVLCCLPLGIVSIVYSNKVSGLWAQGRYAEAHEAANNAKKWAIIGAVVGVVAAVIFVLIYVVAGVLVVSHLPSTTTTTYSGF
>NZ_CP012885.2|WP_042913848.1|5558245_5559187_-|enoyl-CoA-hydratase/isomerase-family-protein
MLRVVDLSSAPEGGPASPPGVIIAVGSADDIARAGTWLDAATFTLTEDACADRRVVTVDSVSDALVELTDRCRRWPHAGGICDDVLRAVDPEGPTLAGVVAESLGYSTLQSGPEFARWLQERGSVRMPDIADPVLADRDGDILRIAFNRPQRHNAFSTDARAALLEALTVAQLDPSVTGIVLSGNGPSFCSGGDLAEFGTFADPASAHLARTRHSPALALDALTTRLGRACRAEVHGRVMGSGLEMAAFCGWVTARGDAVFGLPELALGLIPGAGGTVSVTRRIGRWRTAYLVLSGHTVDADTALDWGLVDES
>NZ_CP012885.2|WP_020823786.1|5559190_5560720_-|acyl-CoA-synthetase
MQIRPYIGADKPAVILYPSGTVVTFDDLEARANRLAHRFRQAGLREGDTVAILMENNEHIHAVMWAARRSGLYYVPINTHLTAAEAAYIVDNSAAKAIIGSAALRETCAGLAEQLPRGLPELLLIAAENEDEGLPGWERYPECVAGQPDTPIDDEIEGDLLQYSSGTTGRPKGIKRELPHVPPADAPGMMSALVGFWMTPDSVYLSPAPLYHTAPSVWSMSAQAGGITTVVMEKFDAEGCLDAIQRHRVTHGQFVPAMFTRMLKLPDAVRHSYDLSSLQRVMHAAAPCPVEIKKQMIDWWGPIIDEYYASSEAHGSTLITAEDWLAHPGSVGKPMGGAVHILDENGDELPAGQAGEIYFEGGYSFEYLNDPTKTASSRSKHGWATVGDIGYLDDEGYLYLTDRRHHMIISGGVNIYPQEAENLLVTHPKVMDAAVFGVPDDEMGQRVTAVVQTVDPADATDAFGDELLAWLRDRLAHYKCPRSIAFEAQLPRTDTGKLYKNGLIEKYSV
>NZ_CP012885.2|WP_014383463.1|5560911_5561997_+|sensor-domain-containing-diguanylate-cyclase
MTAEQESEPAASSFADSDYVDGMERLVHAIQELSLARTLPDLQRIVRSSARELTGCDGATFVLRDNDSCYYADEDAIAPLWKGSRFPIGSCISGWAMLNRDAAVIPDIYGDPRIPHALYRPTFVKSLVMVPIRKLEPIGAIGNYWASRHQPSDQEVHLLQALADSTSIAMENVRVYSELERRVRDRTAALEDANEEIRRLSVTDELTGLNNRRGFYLLAEQKLRGSHHLGHNCVLAFLDVDGLKKVNDELGHDTGDKLIKDVAGVLRTIRRESDILARIGGDEFCVMITESDGDTPSLEERLALAFGNFNKTSERPYRLSASIGFVRAPVSDTANVGELLARADELMYAQKKASPNSRLAG
>NZ_CP012885.2|WP_008261874.1|5561997_5563824_-|phosphoenolpyruvate-carboxykinase-(GTP)
MTSATIPGLDTAPTKHQGLLSWVQEVAELTQPDRVVFADGSDEEFNRLAAQLVEAGTLKKLNEKKHPNSYLALSDPSDVARVESRTFICTEQESGAGPTNNWMDPSEMRSIMTDLYRGCMRGRTMWVVPFCMGPLGADDPKLGVEITDSEYVVISMKVMTRMGKAALEKMGDDGFFVKALHSVGAPLEEGQKDVPWPCNDTKYITHFPETREIMSYGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYFAAAFPSACGKTNLAMLQPTIPGWRAETLGDDIAWMRFGKDGRLYAVNPEFGFFGVAPGTNWKSNPNAMRTIEAGNTVFTNVALTDDNDVWWEGLEGDPQHLIDWKGRDWTPDSDEKAAHPNSRYCTPMSQCPILAPEWDDPQGVPISGILFGARRKTTVPLVTQARDWQHGVFMGATMGSEQTAAAEGKVGTVRRDPMAMLPFLGYHVGDYFQHWLDLGKNADESKMPKVFFVNWFRRGDDGGFLWPGFGENSRVLKWIVDRIEHKAGGQDTPIGIVPKAEDLDLDGLDASSDEVAQALAVNPAEWREELPLIEEWFEFVGDKLPTGVRDEFEALKQRLSEAG
>NZ_CP012885.2|WP_042913914.1|5563963_5565532_-|hypothetical-protein
MSGGDPVAQVDAMVAAVAPDLDPPAVHRCDVILVTGPWMAGVSAVATALQGRLPQHKFVESTDLGPGEVPMAVVFVVSAAAHLTASDCALLDAATEHTDAVVGVVSKIDVHRNWREVVDANREALAAHSPRYGRAPWVGAAALPDAGEPDVDALVAAVSAQLDDPDLARRNRLRAWESRLQTVKRRFDRDVEGSGRRARVEALREERSTALQRRRQAKSERTITLRGQIQQARVQLSHSARNQCATARTELQEHAAGLSRRDMSGFEAHTRARLDEVVAEVSDGTDTQLSDVAQAVGVPVDLPALEKMPEVDVSAPPLKSRRQETWLMIVLGVGFGLGVALTLSRLMSGVVSRLNPALAVVAAVVCVAISVALTFLVINIRALLHDRALLDRWAGDATSSLRSVVEELVATRVLVAESVLSKALLAHDEAENAQASAAVGVIDTELREHALAAARAAAARDREMPAVAAALRAVRAELGEPGIQPAIQTAESPVETGDGDETEKPASRSEDGDPSGASESLL
>NZ_CP012885.2|WP_042913849.1|5565528_5566626_-|hypothetical-protein
MRGQGHQIFVDELARFADGVVDPRVAAIARRTAAPLRVVVRGRRGVGRRTVARALDRAGTASGIAADLQLSASAPDPGADAVVYVVAEVVKPEDAHAIAAAGQPVVVLNKADLSGRRGDGPIAAARARCADLSALIGAPMEPMIGLLAVALDELDDADDQALWAALHTLATHPGAAACLDGSFAGFLAADGPVPAGVRQRLLDTLDLFGIALAVAAIRQGRTPAQVRALLRRMSGVDAVLAKVGVLGAEVRYQRVLGAVAELEALAAGGGLLGERIGGFLSRDDTVVARMAAAVDLAEAAGLDPGGPGSAGVDRDPSAHLPRAVRWQRYSRASASELHRACGADIARGSLRLWSQACASLPGESW

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Crispr_ID: NZ_CP012885_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP012885_9

5805509-5805595

Orphan

Consensus_repeat	Method
GCGGTCGTCGCGGCCGGCGCGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP012885_9

>merge|NZ_CP012885|9|5805509-5805595|CRISPRCasFinder
GCGGTCGTCGCGGCCGGCGCGCCGGGTGACGACGCTGAGCGTCATCATCTCCGCCGAGTGCCCGCGGTCGTCGCGGCCGGCGCGCTC

>NZ_CP012885|9|9|5805509-5805595|CRISPRCasFinder
GCGGTCGTCGCGGCCGGCGCGCCG	GGTGACGACGCTGAGCGTCATCATCTCCGCCGAGTGCCC
GCGGTCGTCGCGGCCGGCGCGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP012885.2\|WP_172417547.1\|5801306_5802386_+\|DUF190-domain-containing-protein	unknown	unknown	gnl\|CDD\|376875
NZ_CP012885.2\|WP_172417548.1\|5805672_5806809_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_051445958.1\|5798257_5798896_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NZ_CP012885.2\|WP_042914067.1\|5804148_5804592_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NZ_CP012885.2\|WP_042914059.1\|5798958_5800053_+\|DUF1214-domain-containing-protein	unknown	unknown	gnl\|CDD\|227689
NZ_CP012885.2\|WP_042914056.1\|5797674_5798271_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP012885.2\|WP_042914074.1\|5810698_5812027_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	unknown	unknown	gnl\|CDD\|176891
NZ_CP012885.2\|WP_042914078.1\|5814853_5817709_+\|RND-family-transporter	unknown	unknown	gnl\|CDD\|129913
NZ_CP012885.2\|WP_014381537.1\|5814480_5814861_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_042914076.1\|5813129_5814347_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP012885.2\|WP_020824010.1\|5806930_5807551_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP012885.2\|WP_038538281.1\|5794074_5795283_-\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238425
NZ_CP012885.2\|WP_042914060.1\|5800052_5801225_+\|sulfotransferase	unknown	unknown	gnl\|CDD\|379204
NZ_CP012885.2\|WP_014381536.1\|5812211_5812472_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP012885.2\|WP_036454255.1\|5812476_5813133_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP012885.2\|WP_042914185.1\|5807653_5808799_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|367273
NZ_CP012885.2\|WP_042914063.1\|5802468_5803362_-\|fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|180045
NZ_CP012885.2\|WP_042914055.1\|5795291_5797517_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NZ_CP012885.2\|WP_042914065.1\|5803710_5804088_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP012885.2\|WP_072501468.1\|5808925_5810686_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|226179

Protein	Function_ID	Function_description	E-value
NZ_CP012885.2\|WP_172417547.1\|5801306_5802386_+\|DUF190-domain-containing-protein	gnl\|CDD\|376875	pfam02641, DUF190, Uncharacterized ACR, COG1993.	4.07699e-29
NZ_CP012885.2\|WP_051445958.1\|5798257_5798896_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	2.85919e-22
NZ_CP012885.2\|WP_042914067.1\|5804148_5804592_+\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	7.07132e-19
NZ_CP012885.2\|WP_042914059.1\|5798958_5800053_+\|DUF1214-domain-containing-protein	gnl\|CDD\|227689	COG5402, COG5402, Uncharacterized conserved protein [Function unknown].	0.00586486
NZ_CP012885.2\|WP_042914056.1\|5797674_5798271_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.41907e-11
NZ_CP012885.2\|WP_042914074.1\|5810698_5812027_+\|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	gnl\|CDD\|176891	cd08882, RHO_alpha_C_MupW-like, C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases. C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas fluorescens MupW and related Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs, also known as aromatic ring hydroxylating dioxygenases). RHOs utilize non-heme Fe(II) to catalyze the addition of hydroxyl groups to the aromatic ring, an initial step in the oxidative degradation of aromatic compounds. RHOs are composed of either two or three protein components, and are comprised of an electron transport chain (ETC) and an oxygenase. The ETC transfers reducing equivalents from the electron donor to the oxygenase component, which in turn transfers electrons to the oxygen molecules. The oxygenase components are oligomers, either (alpha)n or (alpha)n(beta)n. The alpha subunits are the catalytic components and have an N-terminal domain, which binds a Rieske-like 2Fe-2S cluster, and a C-terminal domain which binds the non-heme Fe(II). The Fe(II) is co-ordinated by conserved His and Asp residues. MupW is part of the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens, and may catalyze the oxidation of the 16-methyl group during biosynthesis of this polyketide antibiotic. Mupirocin is a mixture of pseudomonic acids which targets isoleucyl-tRNA synthase and is a strong inhibitor of Gram positive bacterial and mycoplasmal pathogens. This subfamily belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket.	1.0769e-60
NZ_CP012885.2\|WP_042914078.1\|5814853_5817709_+\|RND-family-transporter	gnl\|CDD\|129913	TIGR00833, Putative_membrane_protein_ActII-3, Transport protein. The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate].	0
NZ_CP012885.2\|WP_042914076.1\|5813129_5814347_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.8212e-30
NZ_CP012885.2\|WP_020824010.1\|5806930_5807551_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.16644e-10
NZ_CP012885.2\|WP_038538281.1\|5794074_5795283_-\|thiolase-family-protein	gnl\|CDD\|238425	cd00829, SCP-x_thiolase, Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.	5.80688e-101
NZ_CP012885.2\|WP_042914060.1\|5800052_5801225_+\|sulfotransferase	gnl\|CDD\|379204	pfam13469, Sulfotransfer_3, Sulfotransferase family.	1.10557e-41
NZ_CP012885.2\|WP_036454255.1\|5812476_5813133_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	9.84145e-68
NZ_CP012885.2\|WP_042914185.1\|5807653_5808799_+\|phosphotransferase	gnl\|CDD\|367273	pfam02958, EcKinase, Ecdysteroid kinase. This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates.	1.11616e-16
NZ_CP012885.2\|WP_042914063.1\|5802468_5803362_-\|fructose-bisphosphate-aldolase	gnl\|CDD\|180045	PRK05377, PRK05377, fructose-1,6-bisphosphate aldolase; Reviewed.	0
NZ_CP012885.2\|WP_042914055.1\|5795291_5797517_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	2.296e-95
NZ_CP012885.2\|WP_042914065.1\|5803710_5804088_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	5.47929e-18
NZ_CP012885.2\|WP_072501468.1\|5808925_5810686_+\|amidohydrolase-family-protein	gnl\|CDD\|226179	COG3653, COG3653, N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism].	8.70688e-127

>NZ_CP012885.2|WP_042914067.1|5804148_5804592_+|ATP-binding-protein
MSNLDDRTLFVRTGVAADARSAARTRVEFGAWLNRYFSLCTDRFSDLLLAVNEAIANAAEFAYVDATQRGTVDVRAAYDADSDTLAVTVDDRGRWRQKVPAQRSAQMRGRGIPLMEALADEAAIARTPQGTRVTLVWTGLTRSACTA
>NZ_CP012885.2|WP_042914065.1|5803710_5804088_+|STAS-domain-containing-protein
MGEQSGDVVDPTAFEVGKHQVDQAVVLTVSGEVDMLSSPQLADAIQTALATKPAALIVDLSNVGFLASAGMTVLVSAQAEVEPPTKFAVVANGSATSRPIKLMGIDSVLALYSSLDGALSGIAGE
>NZ_CP012885.2|WP_042914063.1|5802468_5803362_-|fructose-bisphosphate-aldolase
MSNQQQADRMTSGKGFIAALDQSGGSTPKALRLYGIEDSAYSSDKEMFDLIHEMRSRIITAPSFTGDRVLAAILFEQTMDRDIEGKPSTTYLWETKGVVPILKIDKGLADASDDVQLMKPMPGLDELLERAVGKGVFGTKERSVIGGANAEGIAAVVAQQFEVARQVLAHGLVPIIEPEVTISISDKAEAERILRDEITKQLDSVPDGQRVMLKLSLPTEANYYRPLIEHPKVMRVVALSGGYSREEANELLAKNTGLIASFSRALTEGLSVDQTDEQFNTTLDKAIQSIYDASVAG
>NZ_CP012885.2|WP_172417547.1|5801306_5802386_+|DUF190-domain-containing-protein
MDEDCLKLTTYLAERRRTGDGFVSDLLLGLYERHRIAAGVALRGISGFGTMRHFRTDQSLTLSEDPPVVIVAVDTRTKIEALLDPVLTIKQRGLVTLERARLLHEDIGSPQLPEDLHDAVKLTIYVGRKQRVNGTPAYIALCDLMHRRGLAGATVLLGVDGVAHGERQRANFFGRNADVPMMIVVVGSGERIGRVLPELAGLLRTPLFTLERVRVCKRDGQLLQRPHALPGTDEHGLPLWQKLTIYTSESAQRGGAPIHRAIVQRLRQAGTADGATVLRGVWGFHGDHPPHGDKLLSLTRRVPVVTIVIDTPANVAESFAVIDELTSEEGLVTSEMVPALVSDEGDSGQGPPRMARHRY
>NZ_CP012885.2|WP_042914060.1|5800052_5801225_+|sulfotransferase
MTLQDRFAPERLIAAACEEVGSDDFGAEGWRPGLHRVTDGLINDARLSDIGVEIAHLDLMRALKNRLGVIAWRKQHPEVAEQKITAPIFIVGQPRTGTTILYDLLAQDPELRAPLTWEVDEPCPVPQPDTYRDDPRIAQIQATIDMSEQIMPGFLAFHPMGALVGQECVRITAAEFVSMIFSVQYRLPGYYRWLLYEADHAGAYRFHRIFLQHLQSGVPGQWLLKSPAHLWQLDALLAEYPDALIVQTHRDPVNVISSIAALTHHLRRMCSDESSITECAAQSYEEIVVGLDREMALRDSGAVPAGRVIDVRFADFMTDPWTTIKDIYRRLDRELRPDTEQKMREFLASHPSDGGRSRYTWSDTGLDAGEVRERVSAYQDRYAVPAEPLR
>NZ_CP012885.2|WP_042914059.1|5798958_5800053_+|DUF1214-domain-containing-protein
MSQTGVPSVPAAPKARAALEFFQQMLTDVSKIVAEDAESERELAEGLRVVARVSSLCAQMSVEADPDRPSFFDMCSDNRMVGGPNPDGNYYLAMIRGDRRYRITGSRGTSAYLGFQILAGTGLTPRRMAGYFSDTDLALNEGDFTLVLSADEPPDLAGAQWVKIPADASSVVVREYIGDRTAEKLAALRIEALDPGPLTALTDDELADQFTAMAWSLMKLTTLHRTIKPELLETPNILLTAQAADLGAADTTPDNLYMMGTFRLEPGQALVLDIAPPDTRYWNVTLESIWHECLEPRRRHSSVTNRGVRPDADGRVRIAVSDEDFGLGHWLDTGGRQRGFIVLRWLDNPSPPDVTVSVHQGRQR
>NZ_CP012885.2|WP_051445958.1|5798257_5798896_-|TetR-family-transcriptional-regulator
MSATSACAPASVPVTSLAERKRAAMRQRIATAAARLVASRGLAGATVDRIADAADIGRATFFRYFNSKEDAVAEGMNGHWLDRITAALAAQPPELGAIEAVIGAFGELAGDFAEIENQVRELATLTRSSETLDAWTLHVYVRYEVAIAELVAPRMAGLAAHDPRPRLIGALAMAAVRIALDDWLSHGGSLPDRVSRGLAAISVDRAAAVSPG
>NZ_CP012885.2|WP_042914056.1|5797674_5798271_+|TetR/AcrR-family-transcriptional-regulator
MPSDLTEVGTPANTPRRRSEKSRTAIVTATRELLLERGFDGLSIEAVAARAGVGKQTIYRWWPTRPALVADVMLEDADTLLASVNHSGDLAADLVRWVGKLFASLTTPRGSAMLRTLTVACMEHEDTAVKLRAGFSAPLHNSVRARLLADGIDEAVAESAADAIVGGVVYPILSGAQPYSRRRAERTTRLIVDALTRG
>NZ_CP012885.2|WP_042914055.1|5795291_5797517_-|acyl-CoA-dehydrogenase
MTLGLSPEQQELCDAVGQFAARNAPIATTRASFDELAAGRPPGWWDALVGNGFHAVHLPEDLGGQGGRLIDAACVLEAAGKSLLPGPLLPTVAAGAVALLADPTPSAQSLVRDLAAGVTAAVVLPGDGDLHARAVDGRWALSGASEVTPGVCAARIILVGAPTREGDVVWVPVDTQKRAVTVEPVRGTDLVADAGIMRLDDYTATDDEALTGIDAERARCVLLGLVAATTAGIVQWCLQAVTAHLRSREQFGKVIGTFQALQHSAAMLLVNSELATAAAWDAVRAVDESLDQHRMAAAGAAVIAISPAPDLVLDALTMLGAIGFTWEHDVHLYWRRAISLAGSIGPANRWARRLGELTCTQTRDMSVNLGDAEPEFRSWVAETLDAALQLCNDKPAPHGDYEHLATGPQRTLIADAGLMAPHWPAPWGVDADPLKQLIIDEEFAKRPGLVRPSLNIAEWILPSVLAAAPKDLQERLIPATQRGDILWCQLFSEPGAGSDLASLTTRATKVDGGWRINGHKIWTSLAQYADLGALLARTDPEASKHRGIGYFILDMRSPGVEIQPIKTATGQAHFNEVFLNDVFIPDEMLLGGPTDGWSLAIATMAEERSAISGYVKFDRAVALRRLAAQPGPDRDDALRELGELDAYTNAIRALGVRETIRLLDGQASGPASSIAKVAMNVLLRRTFQATLQLTGQVAMVDDPDTAVVEPYLHLPAELIGGGTREIQLNIIAQMILGLPRK
>NZ_CP012885.2|WP_038538281.1|5794074_5795283_-|thiolase-family-protein
MGLRGEAAIVGYVELPPERMTKASPAPFVIEQWAELGAAALADAGLPFEVVDGIVASHLAESEIFVPSTIAEYLGVGARFAEHVDLGGASAAAMVWRAAAAVELGICDAVLCALPARYITPMSPKKPRSLGDALYFGSSSNQYGSPQAEFEIPYGNLGQNGPYGQVAQRYAAIYGYDERAMAKIVVDQRTNANHTEGAIWKDKPLTVDDVLASPVIADPLHMLEIVMPCVGGAAVVVANADVARRSRNRPVWVKGFGEHVPFKTPTYAQDLLQTPIAAAADTAFAMTDLTREQMDMVSIYDCYTITVLLSLEDAGFCEKGKGMEFVAGHDLTFRGDFPLNTAGGQLGFGQAGLAGGMHHVCDATRQIMGRAGAAQVADCHRAFVSGNGGILSEQTTLILEGD
>NZ_CP012885.2|WP_172417548.1|5805672_5806809_-|hypothetical-protein
MAYSAADESFTHQLPSTFDQVHNADPTWSDRCYFFAASPDGTLLLASGYGNNPNTGTGLGYVKVSLADGRHWDLLSGRPVTGDDRGDLSAGPMRWTCVEPLKKWRLEVEPNNSGIVWELYYEPTAPMWELLPMKVRGKNGELLADMYHMKEPGRWSGWVTIDGERISVDGFHGGRDRTFGVRVSDKIDFWLWLDAGFDDHAIEAWIIESADGTVNYVDGGITYADGRLSKRFVKIEHDVEFDGDRKRPTGAALVFTDEDGQAHRVIAEAPHQQVNAYYGLPMAHCQYEDLGGGAYFIHFAWDSGDPDQLSETESKSMALDQLMRFERDGETGWGIFELLLGGQGYARYPNWTAMDMSAFTQDKTPVDRLQEDSDGVRR
>NZ_CP012885.2|WP_020824010.1|5806930_5807551_+|TetR/AcrR-family-transcriptional-regulator
MEPSRRWGDDRAILDDEEARRRILDAAGRCIVRRGNTQFRMGEVADEAGVSRSTVYRYFPGRDDVLLGLMLARIDTALGELVRSLPAPDDPVRSVPEMVLARVESVDGNPLNEALFAAESTAVASALEKGSEPIVELLLQHYGPLLDRWKAAGLLYPDVDFRSIVQWLHAATLFLLAPSWRYRPAADKREFVEQLVVRALVPQIRQ
>NZ_CP012885.2|WP_042914185.1|5807653_5808799_+|phosphotransferase
MKNPVGHAFSFVGLAAHLGRGAGRVATDAVVGGRFGLPRSADEITPAVLSRVMGTTVRSVRVLSRDAGTSSRARLVLTGKNVPESVFVKVAAQTAATRLMGELGRLGHTEVRFYRQLAPQVIGVPYCYGAAFDPWTGRYLLVLEDLPPESCEFPDTLHPLSTDQAGLIVELLAELHATFWGRLPRDGRGPLGWLYTPSGDVTSLLTGSLMRTSIKRLAERASSVDVPVDAGAFIADNYRAVAALIDTPPHTVMHGDAHPGNMYFHGGKAGLLDWQAVRRGHPSRELAYTLITSLTPEVRRASQRELLDDYRRALVAAGGPELDRDDLWLRFRQGALYAYVAPLITTGMGGMQVDDIAMEGLRRGVAALDDLETVAALKGSL
>NZ_CP012885.2|WP_072501468.1|5808925_5810686_+|amidohydrolase-family-protein
MFDLKITGGTIVDGTGAERYRADIGIKDGKIVDVVRRSADGPEMGGEAAETIDATGQVVAPGFVDIHTHYDGQVTWDGLLEPSSGHGVTTIVTGNCGVGFAPVRPGTEQWLIELMEGVEDIPGTALTEGITWGWETYPEYLDAIDKHKFSVDVGSQVAHGAIRAYAMGERGARNEPATPDDIEAMGRLVREAIEAGALGFSTSRTMGHRAMDGEPVPGTFAAEEELFGLGRAMAAGGQAVFELAPQGAAGEDIIGPKKELEWMRRLSGEIDRPVSFALIQVDADPNLWREMLDLSADAHAAGARLYPQIAARPFGMMIGFQGHHGFSHRPTYRRLKAECSREELARRLADPTVKSAILSEDDLPVDPTLLFDGMFALVQHSLGRLYSLGNPPDGMSTPDRTVAAIAQARGEDPLSTLYDLMLEADATNMLMLPLFNYADGNCDAIREMMLHPAGVLGLSDGGAHCGMICDASYPTFLLTHWARDRSRGEKLSLEYVIRKQSRDTAHLFGLTDRGTIEPGKKADINVIDMDALRLHPAAMAFDLPAGGNRILQGASGYAATIVSGTVTRRKDADTGARPGRLVRGAR
>NZ_CP012885.2|WP_042914074.1|5810698_5812027_+|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha
MATARTRSHVQEDAIGAPPEKPTLVPAERYYSPAFAALEVERMWPRVWQLACMVDHIAAPGDYFEYRCGPYGVLIVRDDDGEVRAFQNVCRHRGNSLCTGSGSGLRELKCGYHGWTWDLAGALKRVPNRKGFGSLRMSDFPLIPARVETWAGLVFVNLDLDAMPLIEYLEAVPDDIAWCRLEDFRCYATLTVDVDANWKTIADGYSETYHIQTLHPELLRCVDDIHAPQRIWGHTGKSDQPYGVPSPRLGGALSDEEVWDAYVYTQGALMGAAEGTPFPAEERRPGQTVADLIAERTRAFAAGRGVDLDWADTDRMTRLHQYNVFPNMTLLANADHLTVMCSRPGADPDKGELVMFLTTRMPPGAPRAKPADVRMAADAAEPGIVLTQDIAVLPGLQRGMHQPGFTHLVLSSEERRVINMHRNLERYLDLPTAQQMSGGGAK
>NZ_CP012885.2|WP_014381536.1|5812211_5812472_+|hypothetical-protein
MGVRTAPERLRAMLEGAPLAAHEMINLNFALIAIRLDRESRAARYKRLRQRGARSLMFAGLVMVVLNFLVCMAYLLLNLAEPTAPL
>NZ_CP012885.2|WP_036454255.1|5812476_5813133_-|response-regulator-transcription-factor
MTDPAPEITVLLVDDQDLVRSGLRRILRRKDGFVIVAECADGDEVPAAVAEHRPDVVVMDLRMRRVDGIEATRRLGGRPPVLALTTFNEDELLSGALRAGAAGFVLKDSSAEELIRAVRAVARGDSYLDPAVTSRVLTTYRKAAPGPRGAAIAELTTRELDVLTLIGQGLSNTEIAGELCISGVTVKSHIGRIFGKLDLRDRAAAIVYAYDNGIVAPR
>NZ_CP012885.2|WP_042914076.1|5813129_5814347_-|two-component-sensor-histidine-kinase
MLRAAGDHLRELLRRRGELIPVGITWAALISVDLALVLGGVIGTLQRPASDLPVALTAFALALSPSFAFLVFNMKMTPGPLWATWSASTALTLFGTSTPIHADFAPALLVLMVLVVATLASVAGGLLATASAAALLLAASALHRLDAIVLYLGFIAVAWLLGYLMRTQRLLLAEQIAAQEALAEHAAADERRRIAREVHDVIAHSLSITLLHVTGARRALQQDRDVDDAVDALEQAEKLGRQAMADIRRTVGLLDNWPTKTAQTTPEPGIDDVPALVAGFQQAGLAVTLCVEGPTDHVSAAVGLALYRITQESLANIAKHAPESKASVVLDISPVSARLAVSNLLPAAVVAAKSAEGRGLRGMRQRVDLLGGALDVGPTRDGWSVRAEIPLHEGDTTWRPRWCKL
>NZ_CP012885.2|WP_014381537.1|5814480_5814861_+|hypothetical-protein
MTWTLLHDRMAFMAEVIKAADTDPQAALALIDNSSEVPELFGDEEGLMLSLGQRWITMLVAKLDQAAYEGASAEQVRADLEAAEPGLHALVKIGSRRSIRVRSLSRGEHVAVGLFGGPTGDRQTVA
>NZ_CP012885.2|WP_042914078.1|5814853_5817709_+|RND-family-transporter
MHDRTGLLARLTGRYAVLVVGLWVLAAAAANLAVPQLERVVDSHARSFMPPEAPSAVAAARAAQLFNQTPSNNFVYVVLERNQRLAPGDRQFYDALTTKLGSDHRHVYAVTDLWSQPATAAGAQSSDGRAVSVMVRLAGMLGTSQARDSVNSVRAAIQNLSPPAGLEVHVTGPGATIVDEFSAIDRQMLGITAATIALILLLLLLVYRSPVAAAIPLISVGLALALARAIVAALGQANIVEVSLFSVALMAAMTLGAGTDYAIFLVGRYHEGRRHGVAPEQALTQAYRSVAPVIIGSALTVSVALACLVFTKVGAFRSAGLPCSIGILTTMVAALTLTPALMSLAIRRGYLEPRASKTARRWRRVGTAVARWPAPILVTALGLTLLVALPLTGMRVGFNEPAATPPDTDSNRGYASADRHFAPNALLPDVIAIQADHDLRNPAGLIAIERITRHIMAVPGVRAVQSASRPDGKVPEQATLSYQAGVLGRQFGDTMDSLTRRLQRVSELDGALAQTQAAVDGLGNGLRGGSAGLADMSGAAEDMRAGMDGLQRNVTTVSGYLDPLRDIVGRTPDCAANPICSTVDRVLQPVDSLVQTSARLDAGATKLTSGSSTAAAAMAGLPQSVSAMKGALGQARSATHDLLGLTDTLGPQMRQLTDYMNEIATQFQGSAAADFYMPQRALTDPRYTAVLDHLISENGRAAYLLVYGDGSEWGADGANRADQVRAAIKEATKEGTLTPVEVDLAGVGPVTSDLQRFVAGDTTLLVGAALVLIFLIVTAMLRSPVAGLVVVGTVVLSYASAVGASVLIWQHLFHHDLHWAVAPFAFIALVAVGADYNLLLALRIKQEAAAGLRTGIIRAFGGTGGVVTVAGIVFGLTMMALLTSSVLSIAQIGTTVAVGLLLDTLVVRAFVVPSVVALLGRWFWWPSPLPRRVVAPTVKTPEPQLVTAAAV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP012888.2	7726-7756	1	0.968

1. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to position: 7726-7756, mismatch: 1, identity: 0.968

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcccgcagggccaccggggccg	Protospacer
************************** ****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_LT703508	Mycobacterium chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera plasmid 4	8614-8644	0	1.0
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP015276	Mycobacterium chimaera strain ZUERICH-1 plasmid unnamed 4, complete sequence	17817-17847	0	1.0
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_AP022585	Mycobacterium marseillense strain JCM 17324 plasmid pJCM17324, complete sequence	6473-6503	0	1.0
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP045967	Mycobacterium chimaera strain AUSMDU00007395 plasmid pAUSMDU00007395_04, complete sequence	579-609	0	1.0
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_AP020329	Mycobacterium avium subsp. hominissuis strain JP-H-1 plasmid p3-JPH1, complete sequence	5537-5567	1	0.968
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP015271	Mycobacterium chimaera strain ZUERICH-2 plasmid unnamed 4, complete sequence	1897-1927	1	0.968
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP015277	Mycobacterium chimaera strain ZUERICH-1 plasmid unnamed 5, complete sequence	6197-6227	1	0.968
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP012888	Mycobacterium chimaera strain AH16 plasmid unnamed3, complete sequence	7726-7756	1	0.968
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP022225	Mycobacterium chimaera strain SJ42 plasmid unnamed2, complete sequence	2873-2903	1	0.968
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP045968	Mycobacterium chimaera strain AUSMDU00007395 plasmid pAUSMDU00007395_05, complete sequence	426-456	1	0.968
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_AP020328	Mycobacterium avium subsp. hominissuis strain JP-H-1 plasmid p2-JPH1, complete sequence	13066-13096	2	0.935
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP015270	Mycobacterium chimaera strain ZUERICH-2 plasmid unnamed 3, complete sequence	21716-21746	2	0.935
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP022224	Mycobacterium chimaera strain SJ42 plasmid unnamed1, complete sequence	12185-12215	2	0.935
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NC_005016	Mycobacterium avium plasmid pVT2, complete sequence	1496-1526	2	0.935
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	MN234216	Streptomyces phage Gilgamesh, complete genome	45035-45065	3	0.903
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP053905	Hymenobacter sp. BRD67 plasmid unnamed1, complete sequence	95362-95392	5	0.839
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP053905	Hymenobacter sp. BRD67 plasmid unnamed1, complete sequence	96602-96632	5	0.839
NZ_CP012885_7	7.1\|5487783\|30\|NZ_CP012885\|CRISPRCasFinder	5487783-5487812	30	NZ_CP049157	Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence	1488950-1488979	5	0.833
NZ_CP012885_7	7.1\|5487783\|30\|NZ_CP012885\|CRISPRCasFinder	5487783-5487812	30	NZ_CP049317	Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence	155464-155493	5	0.833
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP053905	Hymenobacter sp. BRD67 plasmid unnamed1, complete sequence	97355-97385	6	0.806
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	MH426726	Erwinia phage Pavtok, complete genome	28356-28386	6	0.806
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	MH067970	Arthrobacter sp. strain ANT_H40 plasmid pA40H1, complete sequence	12712-12742	6	0.806
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP025431	Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence	26555-26585	6	0.806
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP015231	Epibacterium mobile F1926 plasmid unnamed1, complete sequence	523251-523281	7	0.774
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NC_021056	Streptomyces sp. PAMC 26508 plasmid pSP01, complete sequence	13718-13748	7	0.774
NZ_CP012885_7	7.1\|5487783\|30\|NZ_CP012885\|CRISPRCasFinder	5487783-5487812	30	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	347102-347131	7	0.767
NZ_CP012885_7	7.1\|5487783\|30\|NZ_CP012885\|CRISPRCasFinder	5487783-5487812	30	NC_011368	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence	380410-380439	7	0.767
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1305636-1305666	8	0.742
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP032054	Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence	907732-907762	8	0.742
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP016560	Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence	564622-564652	8	0.742
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP021082	Deinococcus ficus strain CC-FR2-10 plasmid pDFI1, complete sequence	125027-125057	8	0.742
NZ_CP012885_7	7.1\|5487783\|30\|NZ_CP012885\|CRISPRCasFinder	5487783-5487812	30	NZ_CP013054	Sinorhizobium americanum CCGM7 plasmid C, complete sequence	1285921-1285950	8	0.733
NZ_CP012885_7	7.1\|5487783\|30\|NZ_CP012885\|CRISPRCasFinder	5487783-5487812	30	NZ_CP014580	Burkholderia sp. OLGA172 plasmid pOLGA1, complete sequence	93211-93240	8	0.733
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP045329	Labrenzia sp. THAF191b plasmid pTHAF191b_a, complete sequence	208068-208098	9	0.71
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP045345	Labrenzia sp. THAF187b plasmid pTHAF187b_a, complete sequence	197523-197553	9	0.71
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP045335	Labrenzia sp. THAF191a plasmid pTHAF191a_b, complete sequence	499832-499862	9	0.71
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP019631	Labrenzia aggregata strain RMAR6-6 plasmid unnamed1, complete sequence	229127-229157	9	0.71
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP039426	Citricoccus sp. SGAir0253 plasmid unnamed2, complete sequence	45108-45138	9	0.71
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP012399	Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence	486415-486445	9	0.71
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP039431	Citricoccus sp. SGAir0453 plasmid unnamed2, complete sequence	45108-45138	9	0.71
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	535807-535837	10	0.677
NZ_CP012885_4	4.1\|3644397\|31\|NZ_CP012885\|CRISPRCasFinder	3644397-3644427	31	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	41064-41094	10	0.677

1. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_LT703508 (Mycobacterium chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera plasmid 4) position: , mismatch: 0, identity: 1.0

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcccgcagggccaccggtgccg	Protospacer
*******************************

2. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP015276 (Mycobacterium chimaera strain ZUERICH-1 plasmid unnamed 4, complete sequence) position: , mismatch: 0, identity: 1.0

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcccgcagggccaccggtgccg	Protospacer
*******************************

3. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_AP022585 (Mycobacterium marseillense strain JCM 17324 plasmid pJCM17324, complete sequence) position: , mismatch: 0, identity: 1.0

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcccgcagggccaccggtgccg	Protospacer
*******************************

4. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP045967 (Mycobacterium chimaera strain AUSMDU00007395 plasmid pAUSMDU00007395_04, complete sequence) position: , mismatch: 0, identity: 1.0

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcccgcagggccaccggtgccg	Protospacer
*******************************

5. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_AP020329 (Mycobacterium avium subsp. hominissuis strain JP-H-1 plasmid p3-JPH1, complete sequence) position: , mismatch: 1, identity: 0.968

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcccgcagggccaccggggccg	Protospacer
************************** ****

6. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP015271 (Mycobacterium chimaera strain ZUERICH-2 plasmid unnamed 4, complete sequence) position: , mismatch: 1, identity: 0.968

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcccgcagggccaccggggccg	Protospacer
************************** ****

7. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP015277 (Mycobacterium chimaera strain ZUERICH-1 plasmid unnamed 5, complete sequence) position: , mismatch: 1, identity: 0.968

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcccgcagggccaccggggccg	Protospacer
************************** ****

8. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP012888 (Mycobacterium chimaera strain AH16 plasmid unnamed3, complete sequence) position: , mismatch: 1, identity: 0.968

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcccgcagggccaccggggccg	Protospacer
************************** ****

9. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP022225 (Mycobacterium chimaera strain SJ42 plasmid unnamed2, complete sequence) position: , mismatch: 1, identity: 0.968

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcccgcagggccaccggggccg	Protospacer
************************** ****

10. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP045968 (Mycobacterium chimaera strain AUSMDU00007395 plasmid pAUSMDU00007395_05, complete sequence) position: , mismatch: 1, identity: 0.968

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcccgcagggccaccggggccg	Protospacer
************************** ****

11. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_AP020328 (Mycobacterium avium subsp. hominissuis strain JP-H-1 plasmid p2-JPH1, complete sequence) position: , mismatch: 2, identity: 0.935

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ttgccggcggcccgcagggccaccggggccg	Protospacer
.************************* ****

12. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP015270 (Mycobacterium chimaera strain ZUERICH-2 plasmid unnamed 3, complete sequence) position: , mismatch: 2, identity: 0.935

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ttgccggcggcccgcagggccaccggggccg	Protospacer
.************************* ****

13. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP022224 (Mycobacterium chimaera strain SJ42 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.935

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ttgccggcggcccgcagggccaccggggccg	Protospacer
.************************* ****

14. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NC_005016 (Mycobacterium avium plasmid pVT2, complete sequence) position: , mismatch: 2, identity: 0.935

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcccgcagggccaccggggtcg	Protospacer
************************** *.**

15. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to MN234216 (Streptomyces phage Gilgamesh, complete genome) position: , mismatch: 3, identity: 0.903

ctgccggcggcccgcagggccacc-ggtgccg	CRISPR spacer
ctgccggccgcccgcagggccgccaggtgcc-	Protospacer
******** ************.** ******

16. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP053905 (Hymenobacter sp. BRD67 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.839

ctgccggcggcccgcagggccaccggtgccg-	CRISPR spacer
ctgccgtcggcccgcacggccacc-gtgtggt	Protospacer
****** ********* ******* ***. *

17. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP053905 (Hymenobacter sp. BRD67 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.839

ctgccggcggcccgcagggccaccggtgccg-	CRISPR spacer
ctgccgtcggcccgcacggccacc-gtgtggt	Protospacer
****** ********* ******* ***. *

18. spacer 7.1|5487783|30|NZ_CP012885|CRISPRCasFinder matches to NZ_CP049157 (Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence) position: , mismatch: 5, identity: 0.833

ggtgt-gtcccgctcgcccagttgatcgcca	CRISPR spacer
-ctgtggtcgcgctcgcacagttgatcgcct	Protospacer
  *** *** ******* ************

19. spacer 7.1|5487783|30|NZ_CP012885|CRISPRCasFinder matches to NZ_CP049317 (Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence) position: , mismatch: 5, identity: 0.833

ggtgt-gtcccgctcgcccagttgatcgcca	CRISPR spacer
-ctgtggtcgcgctcgcacagttgatcgcct	Protospacer
  *** *** ******* ************

20. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP053905 (Hymenobacter sp. BRD67 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.806

ctgccggcggcccgcagggccaccggtgccg-	CRISPR spacer
gtgccgtcggcccgcacggccacc-gtgtggt	Protospacer
 ***** ********* ******* ***. *

21. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to MH426726 (Erwinia phage Pavtok, complete genome) position: , mismatch: 6, identity: 0.806

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
cgcgcagcggcccgcacggccaccgttgccg	Protospacer
*   *.********** ******** *****

22. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to MH067970 (Arthrobacter sp. strain ANT_H40 plasmid pA40H1, complete sequence) position: , mismatch: 6, identity: 0.806

ctgccggc-ggcccgcagggccaccggtgccg	CRISPR spacer
-tgacgatgggcccgcccggccaccggtgccg	Protospacer
 ** **.. *******  **************

23. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP025431 (Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence) position: , mismatch: 6, identity: 0.806

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctggcggcggccggcagggccacggtttcgg	Protospacer
*** ******** ********** * * * *

24. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP015231 (Epibacterium mobile F1926 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.774

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
atgccgacggccagcagggccaccgccagcg	Protospacer
 *****.***** ************ .. **

25. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NC_021056 (Streptomyces sp. PAMC 26508 plasmid pSP01, complete sequence) position: , mismatch: 7, identity: 0.774

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ctgccggcggcctgccgggccacggtcggca	Protospacer
************.** ******* * .* *.

26. spacer 7.1|5487783|30|NZ_CP012885|CRISPRCasFinder matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 7, identity: 0.767

ggtgtgtcccgctcgcccagttgatcgcca	CRISPR spacer
tgaccggcccgctcgcccccttgatcgcca	Protospacer
 *  .* ***********  **********

27. spacer 7.1|5487783|30|NZ_CP012885|CRISPRCasFinder matches to NC_011368 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence) position: , mismatch: 7, identity: 0.767

ggtgtgtcccgctcgcccagttgatcgcca	CRISPR spacer
ggtgtgtcgcgctcgcccagtgaatggggt	Protospacer
******** ************ .** *

28. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 8, identity: 0.742

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
gcgccgccggcccgcaggggcaccggcgtac	Protospacer
 .**** ************ ******.*.

29. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP032054 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence) position: , mismatch: 8, identity: 0.742

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
gcgccgccggcccgcaggggcaccggcgtac	Protospacer
 .**** ************ ******.*.

30. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP016560 (Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence) position: , mismatch: 8, identity: 0.742

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
gcgccgccggcccgcaggggcaccggcgtac	Protospacer
 .**** ************ ******.*.

31. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP021082 (Deinococcus ficus strain CC-FR2-10 plasmid pDFI1, complete sequence) position: , mismatch: 8, identity: 0.742

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
atgccggcgtcccgcagggcctccacgtcct	Protospacer
 ******** *********** **.   **

32. spacer 7.1|5487783|30|NZ_CP012885|CRISPRCasFinder matches to NZ_CP013054 (Sinorhizobium americanum CCGM7 plasmid C, complete sequence) position: , mismatch: 8, identity: 0.733

ggtgtgtcccgctcgcccagttgatcgcca	CRISPR spacer
tggaagtcccgctcgaccagttcatcgctg	Protospacer
 * . ********** ****** *****..

33. spacer 7.1|5487783|30|NZ_CP012885|CRISPRCasFinder matches to NZ_CP014580 (Burkholderia sp. OLGA172 plasmid pOLGA1, complete sequence) position: , mismatch: 8, identity: 0.733

ggtgtgtcccgctcgcccagttgatcgcca	CRISPR spacer
tgcgtgtcccgctcgcccaggtgacacaaa	Protospacer
 *.***************** ***.    *

34. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP045329 (Labrenzia sp. THAF191b plasmid pTHAF191b_a, complete sequence) position: , mismatch: 9, identity: 0.71

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
aggccggctgccagcagggccaccgcgaaca	Protospacer
  ****** *** ************  . *.

35. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP045345 (Labrenzia sp. THAF187b plasmid pTHAF187b_a, complete sequence) position: , mismatch: 9, identity: 0.71

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
aggccggctgccagcagggccaccgcgaaca	Protospacer
  ****** *** ************  . *.

36. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP045335 (Labrenzia sp. THAF191a plasmid pTHAF191a_b, complete sequence) position: , mismatch: 9, identity: 0.71

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
aggccggctgccagcagggccaccgcgaaca	Protospacer
  ****** *** ************  . *.

37. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP019631 (Labrenzia aggregata strain RMAR6-6 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.71

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
aggccggctgccagcagggccaccgcgaaca	Protospacer
  ****** *** ************  . *.

38. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP039426 (Citricoccus sp. SGAir0253 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.71

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ccctcggcggcccggagggctaccggtcggc	Protospacer
*. .********** *****.******

39. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP012399 (Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence) position: , mismatch: 9, identity: 0.71

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
cccgtttcggcccgcagggcgaccggcgcca	Protospacer
*.  .  ************* *****.***.

40. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP039431 (Citricoccus sp. SGAir0453 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.71

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
ccctcggcggcccggagggctaccggtcggc	Protospacer
*. .********** *****.******

41. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 10, identity: 0.677

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
tggccggcggccagcagggcgaccgcgaaga	Protospacer
. ********** ******* ****  .  .

42. spacer 4.1|3644397|31|NZ_CP012885|CRISPRCasFinder matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 10, identity: 0.677

ctgccggcggcccgcagggccaccggtgccg	CRISPR spacer
agcccggctgcccgcagggccagcggcagtc	Protospacer
   ***** ************* ***.. .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

771669 : 812871

Leptospira_phage(66.67%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_072501182.1\|771669_771996_+\|transposase	transposase	NA	NA	NA	NA
WP_142305298.1\|773051_773453_+	hypothetical protein	NA	NA	NA	NA
WP_173662743.1\|773530_774244_+	ABC transporter permease	NA	NA	NA	NA
WP_069953648.1\|774246_775116_+	ABC transporter permease	NA	NA	NA	NA
WP_072501184.1\|775122_776340_+	MCE family protein	NA	NA	NA	NA
WP_069953649.1\|776336_777380_+	MCE family protein	NA	NA	NA	NA
WP_072501485.1\|777376_778942_+	MCE family protein	NA	NA	NA	NA
WP_072501185.1\|778938_780453_+	virulence factor Mce family protein	NA	NA	NA	NA
WP_072501186.1\|780455_781583_+	virulence factor Mce family protein	NA	NA	NA	NA
WP_072501187.1\|781588_783145_+	MCE family protein	NA	NA	NA	NA
WP_142305297.1\|783457_783805_+	hypothetical protein	NA	NA	NA	NA
WP_173662744.1\|786544_787664_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	2.6e-31	34.1
WP_069953651.1\|788852_789152_+	hypothetical protein	NA	NA	NA	NA
WP_065122889.1\|789483_790545_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_069953652.1\|791123_791705_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_065122888.1\|791991_793557_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_173662727.1\|793602_794493_-	metal-dependent hydrolase	NA	NA	NA	NA
WP_162494282.1\|796905_797043_-	hypothetical protein	NA	NA	NA	NA
WP_069953652.1\|797206_797788_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_069953928.1\|799721_800423_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_142305251.1\|800706_801021_+	hypothetical protein	NA	NA	NA	NA
WP_065123596.1\|803580_804000_+\|transposase	transposase	NA	NA	NA	NA
WP_095763959.1\|804634_805231_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_065123598.1\|805532_805754_+	hypothetical protein	NA	NA	NA	NA
WP_065123599.1\|806076_806376_+	hypothetical protein	NA	NA	NA	NA
WP_065123600.1\|806413_807055_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_072501487.1\|807695_809000_+	MCE family protein	NA	NA	NA	NA
WP_065121590.1\|809377_810016_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_173662745.1\|810327_811447_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	4.4e-31	34.1
WP_083533351.1\|811557_812871_+\|transposase	ISL3 family transposase	A0A2H4PDF8	Mycobacterium_phage	5.4e-28	30.3

DBSCAN-SWA_2

829540 : 875177

Leptospira_phage(80.0%)

integrase,transposase

attL 831211:831270|attR 875197:876439

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_173662746.1\|829540_830660_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	2.6e-31	34.1
831211:831270	attL	NA	NA	NA	NA
WP_173662747.1\|831289_832409_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	4.4e-31	34.1
WP_145929546.1\|832449_832752_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_145929520.1\|836483_836687_+	hypothetical protein	NA	NA	NA	NA
WP_069953659.1\|836641_837586_+	R2-like ligand-binding oxidase	NA	NA	NA	NA
WP_069953660.1\|837785_838208_+	OB-fold domain-containing protein	NA	NA	NA	NA
WP_072501192.1\|838207_839350_+	thiolase family protein	NA	NA	NA	NA
WP_069953661.1\|839416_840310_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_072501193.1\|840340_841960_+	acyl--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	1.1e-30	28.1
WP_050790029.1\|842207_843329_+	acyl-CoA/acyl-ACP dehydrogenase	NA	NA	NA	NA
WP_069953664.1\|843452_844505_+\|transposase	transposase	NA	NA	NA	NA
WP_069953665.1\|845002_846229_+	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_042909842.1\|848092_849316_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_042909843.1\|851773_852061_+	DUF1330 domain-containing protein	NA	NA	NA	NA
WP_069953666.1\|852339_854514_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_072501194.1\|858727_859564_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_072501195.1\|859588_860512_+	reductase	NA	NA	NA	NA
WP_083533353.1\|860508_862089_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_069953931.1\|862235_863759_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_069953667.1\|863755_864724_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_158514583.1\|864935_865793_+\|transposase	transposase	NA	NA	NA	NA
WP_173662748.1\|865897_867018_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	1.7e-30	33.7
WP_162494283.1\|867126_867297_+	hypothetical protein	NA	NA	NA	NA
WP_065122889.1\|868355_869417_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_065122890.1\|869849_870491_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_173662747.1\|874056_875177_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	4.4e-31	34.1
875197:876439	attR	NA	NA	NA	NA

DBSCAN-SWA_3

915493 : 960507

Leptospira_phage(50.0%)

integrase,transposase

attL 921748:921766|attR 965779:965797

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_069953690.1\|915493_916903_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_069953691.1\|916899_917712_+	ExeA family protein	NA	NA	NA	NA
WP_095763957.1\|918252_919872_+	fatty acid--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	4.8e-26	26.1
WP_065123242.1\|919910_921056_+	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_065123243.1\|921378_921582_-\|transposase	IS3 family transposase	NA	NA	NA	NA
921748:921766	attL	NA	NA	NA	NA
WP_173662751.1\|922006_923126_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	2.6e-31	34.1
WP_065122879.1\|923195_925109_-\|integrase	tyrosine-type recombinase/integrase	A0A221SAN4	Ralstonia_phage	3.8e-06	25.1
WP_158514584.1\|926241_926493_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_095763937.1\|926532_927207_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_065122891.1\|927648_928071_-	SRPBCC family protein	NA	NA	NA	NA
WP_072501491.1\|928231_929107_-	metal-dependent hydrolase	NA	NA	NA	NA
WP_065122881.1\|930742_931168_-	hypothetical protein	NA	NA	NA	NA
WP_065122882.1\|931291_932305_-\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_065122883.1\|932309_932510_-\|transposase	transposase	NA	NA	NA	NA
WP_072501203.1\|932487_932907_-\|transposase	transposase	A0A2H4PDF8	Mycobacterium_phage	1.5e-11	52.3
WP_065122884.1\|933950_934163_+	hypothetical protein	NA	NA	NA	NA
WP_065122885.1\|935764_938698_-	MMPL family transporter	NA	NA	NA	NA
WP_065122886.1\|938694_939105_-	hypothetical protein	NA	NA	NA	NA
WP_065122887.1\|939193_940057_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_173662728.1\|940591_941479_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_072501204.1\|941548_942418_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_142305296.1\|943312_943498_+	hypothetical protein	NA	NA	NA	NA
WP_173662745.1\|943819_944940_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	4.4e-31	34.1
WP_142305312.1\|945506_945698_+	hypothetical protein	NA	NA	NA	NA
WP_142305313.1\|945704_946283_+	hypothetical protein	NA	NA	NA	NA
WP_173662752.1\|946338_947458_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	4.4e-31	34.1
WP_172832467.1\|947507_947789_-\|transposase	transposase	NA	NA	NA	NA
WP_065119800.1\|947861_949244_-	recombinase XerD	NA	NA	NA	NA
WP_065119801.1\|949320_949668_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_065119802.1\|949903_950344_-\|transposase	transposase	NA	NA	NA	NA
WP_095763958.1\|950333_952529_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_072501205.1\|953568_954087_+	hypothetical protein	NA	NA	NA	NA
WP_069953696.1\|959053_959401_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_173662729.1\|959397_960507_-\|integrase	site-specific integrase	NA	NA	NA	NA
965779:965797	attR	NA	NA	NA	NA

DBSCAN-SWA_4

1955104 : 2013996

Tupanvirus(66.67%)

integrase,transposase

attL 1967401:1967460|attR 2017495:2021052

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_158514585.1\|1955104_1955983_+\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
WP_069953652.1\|1956201_1956783_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_069953759.1\|1957039_1959208_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_080691160.1\|1959213_1960383_+	AAA family ATPase	NA	NA	NA	NA
WP_158514586.1\|1960476_1962999_+	TniQ family protein	NA	NA	NA	NA
WP_069953761.1\|1966435_1967248_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	3.8e-32	33.1
1967401:1967460	attL	NA	NA	NA	NA
WP_042909843.1\|1968212_1968500_-	DUF1330 domain-containing protein	NA	NA	NA	NA
WP_046182709.1\|1968496_1970962_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_042909842.1\|1970958_1972182_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_087139680.1\|1973108_1974379_-\|transposase	IS3 family transposase	A0A2P1JR32	Mycobacterium_phage	3.7e-50	41.7
WP_157679854.1\|1974650_1976450_-	TniQ family protein	NA	NA	NA	NA
WP_042911243.1\|1976627_1976888_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_042911244.1\|1977308_1977896_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_142383138.1\|1978214_1978646_-	hypothetical protein	NA	NA	NA	NA
WP_142383139.1\|1978676_1979054_-	hypothetical protein	NA	NA	NA	NA
WP_080691161.1\|1979016_1979892_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_072501247.1\|1980353_1983353_-	nocobactin polyketide synthase NbtC	NA	NA	NA	NA
WP_042911247.1\|1983349_1984651_-	polyketide synthase	NA	NA	NA	NA
WP_042911248.1\|1984647_1985382_-	thioesterase	NA	NA	NA	NA
WP_087139839.1\|1985378_1985852_-	acetyltransferase	NA	NA	NA	NA
WP_042911250.1\|1986037_1991026_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	1.5e-94	26.7
WP_087139684.1\|1991007_1995486_+	non-ribosomal peptide synthetase	A0A2K9L3I8	Tupanvirus	3.1e-35	23.6
WP_042911252.1\|1995509_1998962_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	5.0e-49	27.6
WP_080691156.1\|1998962_2000351_-	SagB family peptide dehydrogenase	NA	NA	NA	NA
WP_080691157.1\|2002433_2006474_-	non-ribosomal peptide synthetase	A0A2K9L3I8	Tupanvirus	1.5e-41	24.6
WP_051445860.1\|2008828_2009572_-	hypothetical protein	NA	NA	NA	NA
WP_145929528.1\|2009616_2009859_-	hypothetical protein	NA	NA	NA	NA
WP_069953652.1\|2009927_2010509_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_072501249.1\|2011537_2011918_-	DUF4189 domain-containing protein	NA	NA	NA	NA
WP_042909842.1\|2012772_2013996_+\|integrase	site-specific integrase	NA	NA	NA	NA
2017495:2021052	attR	NA	NA	NA	NA

DBSCAN-SWA_5

3658521 : 3667611

Shahe_endorna-like_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_042912268.1\|3658521_3659778_+	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	4.3e-06	34.4
WP_042912270.1\|3659785_3660565_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_029384366.1\|3660660_3661452_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_020822883.1\|3661579_3662386_-	class I SAM-dependent methyltransferase	A0A2R8FDY2	Brazilian_cedratvirus	7.6e-57	53.1
WP_072501358.1\|3662481_3663768_-	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	1.2e-08	44.4
WP_069953851.1\|3664181_3665450_-	glycosyltransferase	A0A1L3KK54	Shahe_endorna-like_virus	4.3e-06	38.7
WP_065502061.1\|3665541_3666348_-	class I SAM-dependent methyltransferase	A0A2R8FDY2	Brazilian_cedratvirus	9.2e-55	52.2
WP_069953852.1\|3666501_3667611_-	NAD-dependent epimerase/dehydratase family protein	A0A2K9L0I7	Tupanvirus	1.5e-15	24.6

DBSCAN-SWA_6

4381806 : 4388382

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_172417591.1\|4381806_4383924_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	3.2e-208	51.6
WP_008259183.1\|4383941_4384394_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A142F1R4	Bacillus_phage	5.8e-14	40.2
WP_008259184.1\|4384425_4384665_-	redoxin NrdH	V5UN81	Mycobacterium_phage	1.3e-20	63.2
WP_008259185.1\|4385193_4385748_-	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	1.2e-05	34.4
WP_008259186.1\|4385839_4386454_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_008259187.1\|4386462_4387506_+	DNA polymerase IV	F1C5A5	Cronobacter_phage	3.9e-21	29.1
WP_008259188.1\|4387440_4388382_-	SDR family oxidoreductase	W8CYX9	Bacillus_phage	1.2e-05	28.8

DBSCAN-SWA_7

4946125 : 4954771

Burkholderia_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014385777.1\|4946125_4947652_+	cyclic nucleotide-binding domain-containing protein	W8CYF6	Bacillus_phage	1.3e-12	37.4
WP_042913325.1\|4947691_4948531_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_042913327.1\|4948527_4949394_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_008260499.1\|4949421_4950417_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	5.8e-75	46.5
WP_042913511.1\|4950418_4951036_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	1.3e-27	38.8
WP_042913329.1\|4951235_4952357_+	acyltransferase	A9YX16	Burkholderia_phage	2.9e-14	27.7
WP_042913331.1\|4952486_4953623_+	acyltransferase	A9YX16	Burkholderia_phage	2.6e-18	28.0
WP_042913512.1\|4953682_4954771_+	acyltransferase	A9YX16	Burkholderia_phage	1.3e-16	29.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP012886

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

48239 : 56109

Mycobacterium_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_072501555.1\|48239_48593_-	hypothetical protein	A0A1D8EVD7	Mycobacterium_phage	5.1e-18	45.5
WP_069954004.1\|48687_48891_-	hypothetical protein	NA	NA	NA	NA
WP_142304815.1\|48929_49220_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_069954006.1\|49586_49871_+	hypothetical protein	NA	NA	NA	NA
WP_069954313.1\|49907_50114_-	hypothetical protein	A0A160DFA4	Gordonia_phage	2.2e-13	53.7
WP_069954007.1\|50237_50576_-	hypothetical protein	G1JWG3	Mycobacterium_phage	4.6e-08	37.7
WP_069954008.1\|50783_51083_-	hypothetical protein	NA	NA	NA	NA
WP_158514591.1\|51406_51571_-	hypothetical protein	NA	NA	NA	NA
WP_069954009.1\|51585_53055_-	AAA family ATPase	A0A0R6PCP6	Moraxella_phage	8.5e-14	35.1
WP_142304814.1\|53051_53324_-	hypothetical protein	NA	NA	NA	NA
WP_072501557.1\|53472_53793_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_142304813.1\|53820_54009_-	hypothetical protein	NA	NA	NA	NA
WP_069954011.1\|54083_54404_-	hypothetical protein	Q19YZ6	Mycobacterium_phage	1.1e-06	40.2
WP_145929609.1\|54456_56109_-	DEAD/DEAH box helicase family protein	I4AZM6	Saccharomonospora_phage	2.2e-87	38.0

DBSCAN-SWA_2

93467 : 146012

Gordonia_phage(28.57%)

tRNA,transposase,integrase

attL 139015:139036|attR 152840:152861

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_069954046.1\|93467_94097_+\|transposase	IS607 family transposase	Q331Z3	Clostridium_botulinum_C_phage	2.9e-19	37.1
WP_145929568.1\|94093_94639_+	hypothetical protein	NA	NA	NA	NA
WP_145929569.1\|94865_95795_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	NA	NA	NA	NA
WP_158514594.1\|95825_95972_-	hypothetical protein	NA	NA	NA	NA
WP_083533472.1\|96383_96989_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_069953652.1\|97100_97682_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_069954051.1\|101157_101361_-	hypothetical protein	NA	NA	NA	NA
WP_069954052.1\|101540_102005_+	hypothetical protein	NA	NA	NA	NA
WP_069954053.1\|102057_102285_+	hypothetical protein	NA	NA	NA	NA
WP_069954054.1\|103581_104862_+\|tRNA	threonine--tRNA ligase	A0A2K9L6B6	Tupanvirus	1.2e-59	33.7
WP_072501568.1\|105492_105837_-	DUF5131 family protein	A0A1B3B211	Gordonia_phage	2.1e-16	43.8
WP_069954056.1\|105929_106628_-	hypothetical protein	NA	NA	NA	NA
WP_069954057.1\|106679_107060_+	hypothetical protein	NA	NA	NA	NA
WP_145929570.1\|107280_107589_+	hypothetical protein	NA	NA	NA	NA
WP_158514595.1\|107968_108109_+	hypothetical protein	NA	NA	NA	NA
WP_158514596.1\|108515_108665_+	hypothetical protein	NA	NA	NA	NA
WP_069954059.1\|108775_109108_+	DUF4031 domain-containing protein	A0A291LA06	Bordetella_phage	5.5e-14	52.9
WP_069954060.1\|109226_109460_+	hypothetical protein	NA	NA	NA	NA
WP_069954316.1\|109483_109765_+	hypothetical protein	NA	NA	NA	NA
WP_072501569.1\|109961_110291_+	ParB N-terminal domain-containing protein	NA	NA	NA	NA
WP_069954317.1\|110546_110807_+	hypothetical protein	A0A142K984	Gordonia_phage	4.8e-13	58.2
WP_158514597.1\|110860_111013_-	hypothetical protein	NA	NA	NA	NA
WP_069954061.1\|111922_112144_+	hypothetical protein	NA	NA	NA	NA
WP_158514598.1\|112186_113893_+	hypothetical protein	NA	NA	NA	NA
WP_069954065.1\|114268_114547_+	hypothetical protein	NA	NA	NA	NA
WP_069954066.1\|114591_115407_+	hypothetical protein	NA	NA	NA	NA
WP_069954067.1\|115403_115658_+	hypothetical protein	NA	NA	NA	NA
WP_069954068.1\|117325_117532_+	hypothetical protein	NA	NA	NA	NA
WP_069954069.1\|117580_117859_+	hypothetical protein	NA	NA	NA	NA
WP_069954070.1\|117863_118175_+	hypothetical protein	NA	NA	NA	NA
WP_069954072.1\|119354_119567_+	hypothetical protein	NA	NA	NA	NA
WP_145929573.1\|119557_120115_+	hypothetical protein	NA	NA	NA	NA
WP_145929574.1\|120152_120632_+	hypothetical protein	NA	NA	NA	NA
WP_069954074.1\|120725_121208_+	hypothetical protein	NA	NA	NA	NA
WP_069954075.1\|121326_121974_+	hypothetical protein	NA	NA	NA	NA
WP_095786373.1\|122190_122631_-	hypothetical protein	NA	NA	NA	NA
WP_173662764.1\|122627_123380_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_069954077.1\|123552_124344_+	hypothetical protein	NA	NA	NA	NA
WP_069953934.1\|125027_125411_+	hypothetical protein	NA	NA	NA	NA
WP_069953690.1\|125462_126872_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	X4YD35	Pseudomonas_phage	1.9e-07	30.8
WP_069953691.1\|126868_127681_+	ExeA family protein	NA	NA	NA	NA
WP_069954078.1\|127781_128075_-	hypothetical protein	NA	NA	NA	NA
WP_069954079.1\|128267_129239_-	hypothetical protein	NA	NA	NA	NA
WP_145929575.1\|129228_129801_-	hypothetical protein	NA	NA	NA	NA
WP_145929576.1\|129933_131319_-	hypothetical protein	NA	NA	NA	NA
WP_158514599.1\|131315_133094_-	hypothetical protein	NA	NA	NA	NA
WP_145929577.1\|133107_133356_+	hypothetical protein	NA	NA	NA	NA
WP_145929578.1\|133529_134042_+	hypothetical protein	NA	NA	NA	NA
WP_069954084.1\|134205_134973_+	hypothetical protein	NA	NA	NA	NA
WP_069954085.1\|135183_135573_-	hypothetical protein	NA	NA	NA	NA
WP_069954086.1\|135666_136074_+	hypothetical protein	NA	NA	NA	NA
WP_069954087.1\|136082_137294_+	hypothetical protein	NA	NA	NA	NA
WP_087139680.1\|137683_138953_+\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	2.2e-55	51.3
139015:139036	attL	NA	NA	NA	NA
WP_007170747.1\|139238_140237_+	Lsr2 family protein	NA	NA	NA	NA
WP_007170748.1\|140274_141054_-	ATP-binding protein	NA	NA	NA	NA
WP_042909843.1\|142042_142330_-	DUF1330 domain-containing protein	NA	NA	NA	NA
WP_046182709.1\|142326_144792_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_042909842.1\|144788_146012_-\|integrase	site-specific integrase	NA	NA	NA	NA
152840:152861	attR	NA	NA	NA	NA

DBSCAN-SWA_3

149253 : 180155

Mycobacterium_phage(14.29%)

transposase,integrase

attL 160403:160419|attR 164022:164038

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_083533498.1\|149253_150564_+\|integrase	tyrosine-type recombinase/integrase	A0A1I9SC88	Mycobacterium_phage	4.3e-09	31.2
WP_072501575.1\|150560_151559_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_069954091.1\|151510_152500_+\|integrase	tyrosine-type recombinase/integrase	A0A2L1IV36	Escherichia_phage	7.0e-12	31.7
WP_158514600.1\|152578_152734_-	hypothetical protein	NA	NA	NA	NA
WP_083533501.1\|152823_153252_-	RES family NAD+ phosphorylase	NA	NA	NA	NA
WP_069954321.1\|153252_153594_-	DUF2384 domain-containing protein	NA	NA	NA	NA
WP_069954092.1\|154188_154383_+	hypothetical protein	NA	NA	NA	NA
WP_069954093.1\|154373_154808_+	PIN domain nuclease	NA	NA	NA	NA
WP_069954094.1\|154931_155276_+	hypothetical protein	NA	NA	NA	NA
WP_083533504.1\|155278_155812_+	hypothetical protein	NA	NA	NA	NA
WP_069953769.1\|156148_156589_-\|transposase	transposase	NA	NA	NA	NA
WP_069953768.1\|158814_159921_-\|integrase	tyrosine-type recombinase/integrase	A0A220NQQ9	Corynebacterium_phage	3.6e-09	31.1
160403:160419	attL	NA	NA	NA	NA
WP_054586091.1\|160483_162097_-	hypothetical protein	NA	NA	NA	NA
WP_054586092.1\|162098_162416_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_054586093.1\|162422_163475_-\|integrase	tyrosine-type recombinase/integrase	A0A142KCU7	Gordonia_phage	2.3e-05	25.7
WP_145929579.1\|164543_164846_-	hypothetical protein	NA	NA	NA	NA
164022:164038	attR	NA	NA	NA	NA
WP_158514601.1\|164972_165095_-	hypothetical protein	NA	NA	NA	NA
WP_069954098.1\|165784_166294_-	(3R)-hydroxyacyl-ACP dehydratase subunit HadC	NA	NA	NA	NA
WP_072501577.1\|166296_166725_-	(3R)-hydroxyacyl-ACP dehydratase subunit HadB	NA	NA	NA	NA
WP_072501641.1\|167613_167946_-	type II toxin-antitoxin system PemK/MazF family toxin	A9D9Y1	Lactobacillus_prophage	2.7e-08	35.5
WP_069954322.1\|167945_168203_-	antitoxin	NA	NA	NA	NA
WP_069954099.1\|168627_168960_+	type II toxin-antitoxin system PemK/MazF family toxin	NA	NA	NA	NA
WP_145929580.1\|169113_169845_-	hypothetical protein	NA	NA	NA	NA
WP_083533558.1\|170920_171094_+	hypothetical protein	NA	NA	NA	NA
WP_145929581.1\|171130_173443_-	hypothetical protein	NA	NA	NA	NA
WP_069954102.1\|173683_174880_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_069954103.1\|175205_176267_-	hypothetical protein	NA	NA	NA	NA
WP_072501581.1\|176263_177193_-	hypothetical protein	NA	NA	NA	NA
WP_158514617.1\|177416_177725_+	DUF4433 domain-containing protein	NA	NA	NA	NA
WP_069954107.1\|177735_178806_+	macro domain-containing protein	B3FJ30	Pseudomonas_phage	6.6e-24	38.8
WP_072501583.1\|179254_179617_-	hypothetical protein	NA	NA	NA	NA
WP_072501642.1\|179804_180155_+\|transposase	IS200/IS605 family transposase	A0A1S5RHE3	Helicobacter_phage	5.1e-18	41.5

DBSCAN-SWA_4

377708 : 423675

Streptomyces_phage(20.0%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_069954258.1\|377708_378197_-\|protease	hydrogenase maturation protease	NA	NA	NA	NA
WP_069954259.1\|378323_379670_-	hypothetical protein	NA	NA	NA	NA
WP_069954260.1\|379666_380308_-	hypothetical protein	NA	NA	NA	NA
WP_069954261.1\|380304_380931_-	hypothetical protein	NA	NA	NA	NA
WP_069954262.1\|380927_381833_-	NifU family protein	NA	NA	NA	NA
WP_069954263.1\|381836_383639_-	nickel-dependent hydrogenase large subunit	NA	NA	NA	NA
WP_069954264.1\|383682_384738_-	hydrogenase expression protein HypE	NA	NA	NA	NA
WP_069954265.1\|385578_385914_-	hydrogenase maturation nickel metallochaperone HypA	NA	NA	NA	NA
WP_069954266.1\|386239_386551_+	hypothetical protein	NA	NA	NA	NA
WP_072501623.1\|386563_387634_+	hypothetical protein	NA	NA	NA	NA
WP_083533564.1\|387875_388280_+	transcriptional repressor	NA	NA	NA	NA
WP_069953652.1\|390068_390650_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_145929607.1\|391925_392702_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_142383117.1\|392880_393246_+	hypothetical protein	NA	NA	NA	NA
WP_142383116.1\|393463_394735_+	hypothetical protein	NA	NA	NA	NA
WP_069954276.1\|396493_396679_+	antitoxin	NA	NA	NA	NA
WP_069954277.1\|396751_397051_-	hypothetical protein	NA	NA	NA	NA
WP_069954278.1\|397156_397615_-	hypothetical protein	NA	NA	NA	NA
WP_069954279.1\|397611_398205_-	ArsR family transcriptional regulator	NA	NA	NA	NA
WP_069954340.1\|398420_398654_-	hypothetical protein	NA	NA	NA	NA
WP_069954280.1\|398763_399057_-	hypothetical protein	NA	NA	NA	NA
WP_158514610.1\|399840_400830_+	beta-propeller fold lactonase family protein	NA	NA	NA	NA
WP_072501626.1\|400888_401566_+	hypothetical protein	NA	NA	NA	NA
WP_072501627.1\|401642_404267_-	hypothetical protein	NA	NA	NA	NA
WP_072501628.1\|404477_405248_+	hypothetical protein	NA	NA	NA	NA
WP_083533566.1\|405354_405576_-	hypothetical protein	NA	NA	NA	NA
WP_069954283.1\|405766_406216_+	hypothetical protein	NA	NA	NA	NA
WP_142383113.1\|406226_407159_-	hypothetical protein	NA	NA	NA	NA
WP_158514611.1\|407215_407863_-	C40 family peptidase	A0A2H4PI41	Streptomyces_phage	4.4e-07	33.0
WP_072501630.1\|408017_408995_-	hypothetical protein	NA	NA	NA	NA
WP_069954287.1\|409073_409298_+	hypothetical protein	NA	NA	NA	NA
WP_069954288.1\|409854_410394_+	AAA family ATPase	NA	NA	NA	NA
WP_069954289.1\|410405_411119_-	phosphotransferase	Q75ZG1	Hepacivirus	3.8e-20	34.5
WP_069954290.1\|411179_412499_-\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	3.1e-217	85.0
WP_142383112.1\|412660_413047_+	XRE family transcriptional regulator	NA	NA	NA	NA
WP_142383111.1\|413101_413668_-	hypothetical protein	NA	NA	NA	NA
WP_083533532.1\|413840_414071_+	nucleotidyltransferase domain-containing protein	NA	NA	NA	NA
WP_069953652.1\|414238_414820_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_142383110.1\|415337_416012_+	S1 family peptidase	NA	NA	NA	NA
WP_072501632.1\|416038_416491_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_142383109.1\|417282_418023_+	hypothetical protein	NA	NA	NA	NA
WP_069954294.1\|418123_418708_+\|transposase	IS607 family transposase	F9VHY9	Thermus_phage	8.5e-18	33.5
WP_069954295.1\|418707_420111_+\|transposase	transposase	A0A0R8V9X2	Thermobifida_phage	3.3e-23	28.8
WP_142383108.1\|420107_420845_+	hypothetical protein	NA	NA	NA	NA
WP_069954296.1\|420863_422876_-\|transposase	transposase	NA	NA	NA	NA
WP_158514612.1\|422883_423675_+\|transposase	transposase family protein	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP012888

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP012885

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP012886

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP012888

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection