| NZ_CP017014.1|WP_070379981.1|3753641_3754598_+|NAD(P)/FAD-dependent-oxidoreductase |
gnl|CDD|223566 |
COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].
|
2.0801e-51 |
| NZ_CP017014.1|WP_084385663.1|3770555_3770924_-|hemophore-related-protein |
gnl|CDD|275322 |
TIGR04529, hypothetical_protein, hemophore-related protein, Rv0203/Rv1174c family. Members of this family occur as paralogs in most Mycobacterium strains, including 2 in M. tuberculosis, 6 in M. avium, and 9 in M. smegmatis. Members have a cleaved N-terminal signal peptide and exactly two Cys residues in the mature protein, both at invariant positions. The best characterized member, Rv0203, is a hemophore, that is, a secreted polypeptide that binds heme and delivers it to a transport system for import. Hemophores are protein analogs of siderophores, natural products that chelate non-heme iron and deliver it to receptors for transport. The unrelated HasA family of hemophores has been described in Gram-negative bacteria such as Yersinia pestis and Pseudomonas aeruginosa. [Transport and binding proteins, Other].
|
0.000155253 |
| NZ_CP017014.1|WP_070379992.1|3768504_3769824_-|HAMP-domain-containing-histidine-kinase |
gnl|CDD|223715 |
COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].
|
5.97111e-36 |
| NZ_CP017014.1|WP_070379983.1|3755549_3756653_-|DegT/DnrJ/EryC1/StrS-family-aminotransferase |
gnl|CDD|99740 |
cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
|
9.50979e-147 |
| NZ_CP017014.1|WP_070379982.1|3754587_3755553_-|Gfo/Idh/MocA-family-oxidoreductase |
gnl|CDD|223745 |
COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].
|
5.96981e-39 |
| NZ_CP017014.1|WP_070379990.1|3767340_3767925_+|dTDP-4-keto-6-deoxy-D-glucose-epimerase |
gnl|CDD|376414 |
pfam00908, dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. This family catalyze the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.
|
2.8709e-82 |
| NZ_CP017014.1|WP_157109703.1|3757837_3758581_+|pentapeptide-repeat-containing-protein |
gnl|CDD|224276 |
COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].
|
9.25757e-11 |
| NZ_CP017014.1|WP_070381018.1|3765394_3766399_-|dTDP-glucose-4,6-dehydratase |
gnl|CDD|224013 |
COG1088, RfbB, dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane].
|
0 |
| NZ_CP017014.1|WP_070379995.1|3771115_3771616_+|polyketide-cyclase |
gnl|CDD|176867 |
cd07825, SRPBCC_7, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
|
1.50105e-36 |
| NZ_CP017014.1|WP_070379989.1|3766463_3767336_+|glucose-1-phosphate-thymidylyltransferase-RfbA |
gnl|CDD|130274 |
TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].
|
3.93973e-171 |
| NZ_CP017014.1|WP_070381017.1|3762508_3764011_-|SulP-family-inorganic-anion-transporter |
gnl|CDD|223732 |
COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].
|
5.54175e-131 |
| NZ_CP017014.1|WP_084385809.1|3769820_3770498_-|response-regulator-transcription-factor |
gnl|CDD|223816 |
COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].
|
6.09594e-79 |
| NZ_CP017014.1|WP_070379980.1|3749837_3750641_-|glycosyltransferase |
gnl|CDD|133031 |
cd04188, DPG_synthase, DPG_synthase is involved in protein N-linked glycosylation. UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.
|
1.26225e-38 |
| NZ_CP017014.1|WP_070381015.1|3752943_3753549_-|helix-turn-helix-transcriptional-regulator |
gnl|CDD|380339 |
cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.
|
8.71555e-18 |
| NZ_CP017014.1|WP_070381016.1|3750761_3752954_+|hypothetical-protein |
gnl|CDD|370572 |
pfam09586, YfhO, Bacterial membrane protein YfhO. This protein is a conserved membrane protein. The yfhO gene is transcribed in Difco sporulation medium and the transcription is affected by the YvrGHb two-component system. Some members of this family have been annotated as glycosyl transferases of the PMT family.
|
2.94292e-09 |
| NZ_CP017014.1|WP_070379991.1|3768081_3768429_+|CD225/dispanin-family-protein |
gnl|CDD|377375 |
pfam04505, CD225, Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.
|
6.94877e-15 |
| NZ_CP017014.1|WP_070379979.1|3747855_3749745_-|glycosyltransferase |
gnl|CDD|224137 |
COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].
|
1.12876e-27 |
| NZ_CP017014.1|WP_070379984.1|3756775_3757504_+|acyl-ACP--UDP-N--acetylglucosamine-O-acyltransferase |
gnl|CDD|100042 |
cd03351, LbH_UDP-GlcNAc_AT, UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic pathway and is also referred to as LpxA. Lipid A is essential for the growth of Escherichia coli and related bacteria. It is also essential for maintaining the integrity of the outer membrane. UDP-GlcNAc acyltransferase is a homotrimer of left-handed parallel beta helix (LbH) subunits. Each subunit contains an N-terminal LbH region with 9 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), and a C-terminal alpha-helical region.
|
5.53258e-58 |
| NZ_CP017014.1|WP_070379988.1|3764445_3765378_+|flippase-like-domain-containing-protein |
gnl|CDD|377103 |
pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.
|
8.75696e-11 |
