CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP017774	Flavobacterium commune strain PK15 chromosome, complete genome	4 crisprs	csa3,DEDDh,cas3,WYL,PrimPol,RT	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP017774_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017774_1

118183-118288

Orphan

Consensus_repeat	Method
TTATCTGTGACTTCGCGATAGCGAATCCGTTTAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017774_1

>merge|NZ_CP017774|1|118183-118288|CRISPRCasFinder
TTATCTGTGACTTCGCGATAGCGAATCCGTTTAATAAGCGTACAATTAACAAAAAATACAACAATCCGCTTTTATCTGTGTCTTCGCGATAGCGAATCCGTTTAAT

>NZ_CP017774|1|1|118183-118288|CRISPRCasFinder
TTATCTGTGACTTCGCGATAGCGAATCCGTTTAAT	AAGCGTACAATTAACAAAAAATACAACAATCCGCTT
TTATCTGTGTCTTCGCGATAGCGAATCCGTTTAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017774.1\|WP_071183307.1\|127515_128718_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NZ_CP017774.1\|WP_071183308.1\|130859_131666_+\|DUF3822-family-protein	unknown	unknown	gnl\|CDD\|378980
NZ_CP017774.1\|WP_071183302.1\|119252_120041_+\|acetylglutamate-kinase	unknown	unknown	gnl\|CDD\|239771
NZ_CP017774.1\|WP_071183298.1\|115494_116691_+\|glutamate-5-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|234685
NZ_CP017774.1\|WP_071186032.1\|114325_115465_+\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|235056
NZ_CP017774.1\|WP_071183291.1\|106698_107319_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017774.1\|WP_071183304.1\|121342_122623_+\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NZ_CP017774.1\|WP_071183301.1\|118312_119266_+\|N-acetylornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|235304
NZ_CP017774.1\|WP_071183296.1\|111930_113124_+\|argininosuccinate-synthase	unknown	unknown	gnl\|CDD\|238957
NZ_CP017774.1\|WP_071183293.1\|109600_110779_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017774.1\|WP_071186034.1\|129112_130534_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|350691
NZ_CP017774.1\|WP_071183306.1\|124630_127240_+\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529
NZ_CP017774.1\|WP_071183297.1\|113264_114242_+\|N-acetyl-gamma-glutamyl-phosphate-reductase	unknown	unknown	gnl\|CDD\|234761
NZ_CP017774.1\|WP_071183303.1\|120124_121201_+\|M20-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349902
NZ_CP017774.1\|WP_071183299.1\|116935_117697_+\|glutamate-5-kinase	unknown	unknown	gnl\|CDD\|239775
NZ_CP017774.1\|WP_071183300.1\|117760_118141_+\|GxxExxY-protein	unknown	unknown	gnl\|CDD\|275083
NZ_CP017774.1\|WP_071183305.1\|122696_123899_-\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NZ_CP017774.1\|WP_071183292.1\|107881_109351_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340952
NZ_CP017774.1\|WP_071183295.1\|111228_111846_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|173926
NZ_CP017774.1\|WP_071186033.1\|124090_124480_-\|bacillithiol-system-redox-active-protein-YtxJ	unknown	unknown	gnl\|CDD\|378538

Protein	Function_ID	Function_description	E-value
NZ_CP017774.1\|WP_071183307.1\|127515_128718_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	2.71519e-106
NZ_CP017774.1\|WP_071183308.1\|130859_131666_+\|DUF3822-family-protein	gnl\|CDD\|378980	pfam12864, DUF3822, Protein of unknown function (DUF3822). This is a family of uncharacterized bacterial proteins. However, structural-similarity searches indicate the family takes on an actin-like ATPase fold.	1.90775e-76
NZ_CP017774.1\|WP_071183304.1\|121342_122623_+\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NZ_CP017774.1\|WP_071183298.1\|115494_116691_+\|glutamate-5-semialdehyde-dehydrogenase	gnl\|CDD\|234685	PRK00197, proA, gamma-glutamyl phosphate reductase; Provisional.	1.78016e-159
NZ_CP017774.1\|WP_071186032.1\|114325_115465_+\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|235056	PRK02627, PRK02627, acetylornithine aminotransferase; Provisional.	2.24441e-125
NZ_CP017774.1\|WP_071183306.1\|124630_127240_+\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NZ_CP017774.1\|WP_071183301.1\|118312_119266_+\|N-acetylornithine-carbamoyltransferase	gnl\|CDD\|235304	PRK04523, PRK04523, N-acetylornithine carbamoyltransferase; Reviewed.	6.83569e-104
NZ_CP017774.1\|WP_071183303.1\|120124_121201_+\|M20-family-metallo-hydrolase	gnl\|CDD\|349902	cd05651, M20_ArgE_DapE-like, M20 peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases. Peptidase M20 family, uncharacterized protein subfamily with similarity to acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE) subfamily. ArgE/DapE enzymes catalyze analogous reactions and share a common activator, the metal ion (usually Co2+ or Zn2+). ArgE catalyzes a broad range of substrates, including N-acetylornithine, alpha-N-acetylmethionine and alpha-N-formylmethionine, while DapE catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelate (L,L-SDAP) to L,L-diaminopimelate and succinate. Proteins in this subfamily are bacterial, and have been inferred by homology as being related to both ArgE and DapE.	0
NZ_CP017774.1\|WP_071183296.1\|111930_113124_+\|argininosuccinate-synthase	gnl\|CDD\|238957	cd01999, Argininosuccinate_Synthase, Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In humans, a defect in the AS gene causes citrullinemia, a genetic disease characterized by severe vomiting spells and mental retardation. AS is a homotetrameric enzyme of chains of about 400 amino-acid residues. An arginine seems to be important for the enzyme's catalytic mechanism. The sequences of AS from various prokaryotes, archaebacteria and eukaryotes show significant similarity.	5.04232e-143
NZ_CP017774.1\|WP_071186034.1\|129112_130534_-\|AAA-family-ATPase	gnl\|CDD\|350691	cd17933, DEXSc_RecD-like, DEXS-box helicase domain of RecD and similar proteins. RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	7.47423e-43
NZ_CP017774.1\|WP_071183297.1\|113264_114242_+\|N-acetyl-gamma-glutamyl-phosphate-reductase	gnl\|CDD\|234761	PRK00436, argC, N-acetyl-gamma-glutamyl-phosphate reductase; Validated.	1.74475e-148
NZ_CP017774.1\|WP_071183305.1\|122696_123899_-\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	2.99275e-107
NZ_CP017774.1\|WP_071183302.1\|119252_120041_+\|acetylglutamate-kinase	gnl\|CDD\|239771	cd04238, AAK_NAGK-like, AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in bacteria and photosynthetic organisms using either the acetylated, noncyclic (NC), or non-acetylated, cyclic (C) route of ornithine biosynthesis. Also included in this CD is a distinct group of uncharacterized (UC) bacterial and archeal NAGKs. Members of this CD belong to the Amino Acid Kinase Superfamily (AAK).	1.51113e-73
NZ_CP017774.1\|WP_071183300.1\|117760_118141_+\|GxxExxY-protein	gnl\|CDD\|275083	TIGR04256, conserved_hypothetical_protein, GxxExxY protein. Members of this protein family average about 130 residues in length and include an almost perfectly conserved motif GxxExxY. Members occur in a wide range of prokaryotes, including Proteobacteria, Perrucomicrobia, Cyanobacteria, Bacteriodetes, Archaea, etc.	6.31951e-50
NZ_CP017774.1\|WP_071183299.1\|116935_117697_+\|glutamate-5-kinase	gnl\|CDD\|239775	cd04242, AAK_G5K_ProB, AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine) biosynthesis. G5K is subject to feedback allosteric inhibition by proline or ornithine. In microorganisms and plants, proline plays an important role as an osmoprotectant and, in mammals, ornithine biosynthesis is crucial for proper ammonia detoxification, since a G5K mutation has been shown to cause human hyperammonaemia. Microbial G5K generally consists of two domains: a catalytic G5K domain and one PUA (pseudo uridine synthases and archaeosine-specific transglycosylases) domain, and some lack the PUA domain. G5K requires free Mg for activity, it is tetrameric, and it aggregates to higher forms in a proline-dependent way. G5K lacking the PUA domain remains tetrameric, active, and proline-inhibitable, but the Mg requirement and the proline-triggered aggregation are greatly diminished and abolished, respectively, and more proline is needed for inhibition. Although plant and animal G5Ks are part of a bifunctional polypeptide, delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR; ProA); bacterial and yeast G5Ks are monofunctional single-polypeptide enzymes. In this CD, all three domain architectures are present: G5K, G5K+PUA, and G5K+G5PR.	1.19551e-98
NZ_CP017774.1\|WP_071183292.1\|107881_109351_+\|MFS-transporter	gnl\|CDD\|340952	cd17394, MFS_FucP_like, Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.53715e-75
NZ_CP017774.1\|WP_071183295.1\|111228_111846_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|173926	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate. NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.	0.00130903
NZ_CP017774.1\|WP_071186033.1\|124090_124480_-\|bacillithiol-system-redox-active-protein-YtxJ	gnl\|CDD\|378538	pfam11009, DUF2847, Protein of unknown function (DUF2847). Some members in this bacterial family of proteins with unknown function are annotated as YtxJ, a putative general stress protein. This cannot be confirmed.	1.50854e-51

>NZ_CP017774.1|WP_071183300.1|117760_118141_+|GxxExxY-protein
MELLHEELTNLIIKTFYEVYNELGYGFLEKVYQNSLYLELKNKGLKVEPQKRIPVFYKGTEVGEYFADLMVEDKIILELKAADYIVKEFENQILNYLRATDCEVGLLLNFGKKPEFKRKIFENDRK
>NZ_CP017774.1|WP_071183299.1|116935_117697_+|glutamate-5-kinase
MAKKRILLKLGSNTLTKETNHISRGKIEDIGMQIAALNDEYEFIIVSSGAIAAAKQFVKLDNNDKDVFVKQALASIGQPHLMRIYNENFKDLGLNTSQCLLSYSDFEKEQTRKNIVNTINVLVKNNYIPIINENDTVATDEIKFGDNDKLAALAAVLLKVDILIIATNTDGFYTKESMDKGTPETILSVKELKDLEKEIGDSKSSHGTGGMQSKIEAVAIAKEANIETWIINGLKDNFILNALKNEIAFTKII
>NZ_CP017774.1|WP_071183298.1|115494_116691_+|glutamate-5-semialdehyde-dehydrogenase
MSTILSIEKRNAVLTTMAALLEQEREALKAINQQDLANYNGEDLAMEKRLLVDDAKVDGMILSVKQLAGQEDPVGQVRYEFTHENGMKISNKTAAFGTILIIYESRPDVTVEAGGIAFKSGNKILLKGGKESLLSNQKIVSLWHQALESNGVSTDWVEYLNYDRVQTQAFLEKPTQRVDLIVPRGGEKLIEFTKKHASCPVIVSGRGNNFVYVNADADLDKAMAIIINGKTSNISVCNALDKVLIDTNVPNWEGFANELVAKLKAYNVTILGDDAFAKATQVPAIENDLIWYEEFLDYKIVIGTIDSKQEAIAKINKYCGGHSASIITEDKAIAQEFMENIDASSVYHNASTRFTDGGQFGLGGELAISTDKLHQRGPIGLQHLVTNKWYIYGDGQVR
>NZ_CP017774.1|WP_071186032.1|114325_115465_+|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme
MNLFDVYPLYPITPVKALDCTITDDKGIEYLDLYSGHGVISIGHTQPDYVAKVKEQLDNLSFYSNAIQNPLQVELAEKLGKASGLTDFSLFLCSSGAEANENALKVASFHTNKSRVIAFDNSFHGRTSAAVAVTDNKKIVAPLNAQQVVTFLPLNQIDLVEAELKKGDVCAVIIEPIQGVGGLDQGTTEFFQALEKACAAHDVVLILDEVQSGYGRSGKFFAFQHHGINPDIVTTAKGMGNGFPIGGVLISPKFQASYGLLGTTFGGSHLACAAGIAVLDVIESKNLIENTNKVSEYFFEAIKVIPEIIKVKGRGLMLGVEFDFDVSALRKKMIIEKYIFTGGANNKNLLRILPPLTITTAAIDAFIVALQESLAELKA
>NZ_CP017774.1|WP_071183297.1|113264_114242_+|N-acetyl-gamma-glutamyl-phosphate-reductase
MIKVGIIGGSGYTAGELIRILMFHPNAKLDFVYSTTNAGKPLYVAHHDLMGDIEMNFTDVINPDVDVLFLCLGHGKSISFLENNKFSDNTKIIDLGNDFRLIKDKDFNGKSFVYGLPELNKADIKNANYIANPGCFATAIQLALLPLAADGLLTEDVHINATTGSTGAGVGLAATSHFSWRNNNLSHYKVFEHQHLGEINQSINQLQADYSDELIFIPNRGDFPRGIFATLYTKSEECLEDLVAKYEAFYADQPFVTVTTTNINMKQVVQTNKCIISLLKKGNRVLITSIIDNLLKGASGQAVQNMNLMFGLEETTGLHLKPSGF
>NZ_CP017774.1|WP_071183296.1|111930_113124_+|argininosuccinate-synthase
MKKVVLAYSGGLDTSYCLKYLKNEQGYEVHTVLINTGGFDDAELKAIEDRAYELGSAKHANLTILDKYYDKAIKYLIYGNVLKNNTYPLSVSAERVFQAIEAIKYAKSVGATAIAHGSTGAGNDQIRFDLIFQTIAPEIEIITPIRDLKLSRQEEVDYLSKNGVHYSWEKAQYSINKGLWGTSVGGKETLTSSQPLPSEAYPSQLQKEGEEKVILEFKKGELVAVNGVADKPSNNIVVLEKLASAYAIGRDIHVGDTIIGIKGRVGFEAAAPLIIIKAHHLLEKHTLGKWQQYWKEQLGNWYGMLFHEGQFLDPVMRNIETFLEDTQKTVNGKVFVSLKPYHFSLDGIESDNDLMNTGFGQYGEMNNAWTSEDAKGFIKILGNAQNIFSSVNNETYE
>NZ_CP017774.1|WP_071183295.1|111228_111846_+|GNAT-family-N-acetyltransferase
MNISIVIAQEEHFKYAQIICDTIETSALLRGTGIAKRTPEYVQKKMENRDAVIALDKNGDFAGFCYIESWQHGKFVAHSGLIVHPDFRNLGLAKKIKTFVFNYSLKKYPGAKVFGITTGLAVMKINSDLGYKPVPFSELTSDPTFWSGCKTCTNFEILKSKDYKMCLCTGMLYDPAEKPKDPPKHPFNVRIWNRLKKIKQALFLE
>NZ_CP017774.1|WP_071183293.1|109600_110779_+|hypothetical-protein
MKKHLLLLITLIFITACGVKQTRNMLTSGNYDEAIDNAVNNLRSNKDKKGNQDYVYLLEEAFFKAKERDLNSLNLLEQDKNPSNLEKIYNTYIQLDRRQEKIKPLLPLQLLKEGKNAKFSFDNYNKQIVESKNALSKYLYDNSKALLKSTNKMDIRKAYDDLEYLNQINPNYQNTLQLQEEALIKGRYYVTVALRNQTNMVIPVDLQNDLLDFNTLGMNDKWTIFHNTLQKQIKYDYQIVVNFKDINITPEQIKEKEFVKEKIIKDGVKDLLDKNGKPVKDSLGKVIKVDNLKTIVIRIREFNQFKASQITANVDYIDFKNKQLLQSFPLTSESVFKNDYATYKGDKRATEESYYSYFNRKLVPFPSNEQMIYNTGEDLKSKLKGILVKNKI
>NZ_CP017774.1|WP_071183292.1|107881_109351_+|MFS-transporter
MNSENLQTKWGQFISLVTVFFFWGFVGSANDILIPVFKKVFTLSQVQSQLVAWAFYAAYFVGSIIFFLVSLKSDVLQKFGYKKTLAAGLTLSAFGSFLFVPAATMESFPFFLTALFTVGLGFSIQQIVANPLAIKMGSPATGAHRLTLAGGVNSFGTTIGAILLGIALFGMGSSKETALSLEDIKLPFIILGCAFILVALFMLFSKIEDPAKEEEIKIEAGNKKFAISDYPQLYLGMIAIFIYVGTEVSIISNLPALLKTAEFGNILEESIPPFIALYWGSLMIGRWNGGVNVFNTSKLTTMALKFIVPALAFGVIIATNIFAEHEVDAFYIYPIWILIFILISFIGGKNAGKTLMLFGISGLVMMLMGLIYPDREIAKFFFISGGLFLSIMWPSIFDLAIAGLGKNTGKASSFLIMMILGGGVIPLVQGRICDFDLSNPEGIFGISWTHFSYIIPLLGFGYLAFYGFYCPKILKKQGVSYVETEGGAH
>NZ_CP017774.1|WP_071183291.1|106698_107319_-|hypothetical-protein
MIKNVLFFLLFLIILFSSSSCSRGIYQKEIVTQTTGIDFSNGKWLLGNIDVDYDVKDKLTRKVVKDFSKYLNNRLVNSINESSLLIANNVPLNPSKSMILDLKKGTGYDYFINIKYFNEKKHSLNSIAGKYVDRFTVDKYYYTKDWNHYIVQLEVYDLNLAQIIYSQRVRGALGDNTGITTSKPIKGIVIGCYQMIMKDIDKKSRN
>NZ_CP017774.1|WP_071183301.1|118312_119266_+|N-acetylornithine-carbamoyltransferase
MNFISIQNIDSLDKWVKQALKIKKNPLKNKKLGKNKTLGMLFFNSSLRTRLSTQKAAMNLGMNVIVMNFNSEGWTLEFQDGVVMDQGSSEHIKEAAAVVSQYCDIIAIRAFAGLVDKEKDNAETVISGFLKYASVPVVNMESATGHPMQSLADAITMAEHKTKHRAKVVLTWAPHPRALPQAVPNSFVEMMQKQENMDFVITHPEGYELNPEITKDSKIEYDQNKAFENADFIYAKNWSNYKEYGKITNSDPNWTVTAEKMALTNNAKFMHCLPVRRNVIVTDEVIDSENSVVIEQANNRTYSAQLVLQKILENGKK
>NZ_CP017774.1|WP_071183302.1|119252_120041_+|acetylglutamate-kinase
MEKSKQSLSIIKIGGNIIDNPTELAHFLADFSKIEGNKILVHGGGKSATKMAQSIGLVPQMIDGRRITDKPMLDVVVMIYAGEINKNVVAQLQAHNTNAMGFSGADGNLIQSTKRDHPTIDYGFVGDVQKVNTPLLETLINSGIVPVFCAITHDKNGQLLNTNADTIASELAIAASEVFEVTLNYCFEKAGVLTDVEDENSVIRQINSALYSQLKEEGAIHSGMIPKLDNCFNSLSKGVQKIKIGHHRMLKNSEAICTSIEL
>NZ_CP017774.1|WP_071183303.1|120124_121201_+|M20-family-metallo-hydrolase
MKNIETLIQEAIALLKSLIQTPSFSSEEEQTALLIENWFTQNNIPFERENNNVWAYNKHFDKSKPTLLLNSHHDTVRPNQGYTNDPFEAKVEDGKLFGLGSNDAGGCLVSLIATFTHFYANENLPYNIVVAATAEEESSGKNGLNSILKHLPELECAIVGEPTLMQLAVAEKGLLVLDVVVKGTASHAAHNNPDNPIYNAMPVIEWFKSYQFEKISEVLGPVKMTVTQVTAGKQHNVVPAECHLVVDIRVNDCYNNTEILDTVRANVNAEVTPRSMHLNASSIPVSHGLVQAGIALGRTTYGSPTLSDQSVLYCKSLKLGPGESLRSHSANEFIYVNEIEEGIELYIKILTDFFNNIK
>NZ_CP017774.1|WP_071183304.1|121342_122623_+|argininosuccinate-lyase
MKLWEKGIPTDKQIDLFTVGNDRELDLILAKHDVTGNIAQAKMLAKIGLITHQECEDLLGALAEIQEDIKAGNFTIEDSFEDVHSKVEYLLTQKVGDAGKKIHTARSRNDQVLVDMNLYLKEEVLQLKQQVKALFDLLMASAEKYQNVLLPGYTHLQIAMPSSFGMWFSAYAESLIDDMSMLNAALKVVDQNPLGSAAGYGSSFPIDRTFTTKEMGFSTLKYNSVAAQMSRGKSEKTVSFAMASVAGTLSKFAYDVCLYMSQNFDFIGLPANLTTGSSIMPHKKNPDVFELIRGKCNKIQSLPYELTLITNNLPSGYHRDLQLLKEGVFPAIQNLKACLDIAIFSIPDIKVKENILEDKKYDYLFTVDTLNEMVSAGIPFRDAYKEVALQIEAGNYKSPKATKHSHEGSINNLCLNEIKEKMNLAY
>NZ_CP017774.1|WP_071183305.1|122696_123899_-|IS256-family-transposase
MIDKDDLLNNKDFYKSFKNAEDLTSFFQTMHKRAVEHMLEAELDAHLDNEKHDKTTKGNYRNGHGTKKIKTSFGQQEIKVPRDRDSSFNPLLVPKRENIAQGIENVIISLYAKGMSVSNIEEQIKEVYDFEVSSSTISRITNTITNEVVTWQNRPLEELYLIVWMDGIVFKVREGSKVINKTIYLAVGLNRDGKKDVLGMWLGKNESSSFWMSVLTDLKARGVEDILITATDNLNGFTQTIRSVFPESQTQICVVHQIRNACKYVVWKDRKQFTADMKHIYNAPTKQAAELALNDFADKWESKYSYAIKSWRDNWDELTVFFDFPIEIRKIIYTTNLIENLNGKIRKYTKNKMSFPTDDAVLKSVFLALREATKKWSMPIQNWGIVLNQFTLIFEKRLRL
>NZ_CP017774.1|WP_071186033.1|124090_124480_-|bacillithiol-system-redox-active-protein-YtxJ
MSFLKNFFGSEETPKQQESKINWELLTDVDQLGEIIFNSNEKPAVIFKHSTRCSVSRMALKQFENEFNLGEEVTPYFLDLLNYREISNEIANRFNVYHESPQILLIKDGKSVYDASHSDIDAGDLSDKL
>NZ_CP017774.1|WP_071183306.1|124630_127240_+|ATP-dependent-chaperone-ClpB
MNINKFTIKSQEAIQLSQQLAQSNGQQQIENEHIFKAIFEVDENVAPFILKKLNVNVPLFLQILDSTIQSFPKVSGGDIMLSREANKTLNEAEIIAQKMNDEYVSIEHLILAIFASKSKVAQILKDQGVTEKGLKVTIEELRKGERVTSASAEETYNSLNKYAKNLNELARSGKLDPVIGRDEEIRRVLQILTRRTKNNPMLVGEPGVGKTAIAEGLAHRIVDGDVPENLKEKIVYSLDMGALIAGAKYKGEFEERLKSVVKEVTSAEGDIVLFIDEIHTLVGAGGGEGAMDAANILKPALARGELRAIGATTLDEYQKYFEKDKALERRFQKVMIEEPDTESAISILRGIKEKYETHHQVQIKDEAIIAAVELSQRYITNRFLPDKAIDLMDEAASKIRMEINSKPEELDVLDRKVMQLEIEIEAIKRENDESKLKILGMELANLKEERNKIFAKWKSEKDIVENIQAVKKEIEDFKYEAERAERDGDYGKVAEIRYGKIKEAQERLETFGKELQENQSGGSSLIKEEVTREDIAEVVAKWTGIPVVKMLQGEREKLLHLEEELHRRVVGQEEAIEAVSDAVRRSRAGLQDMKKPVGTFLFLGTTGVGKTELAKALAEYLFDDENAMTRIDMSEYQERHAVSRLVGAPPGYVGYDEGGQLTEAVRRKPYSVILLDEIEKAHPDTFNILLQVLDEGRLTDNKGRLADFKNSIIIMTSNMGSQIIQEKFENLKGGLEAATEAAKVEVLGLLKQTVRPEFINRIDEIVMFTPLSNANIAQIVGLQLKSVTKMLAQQGITMDATPQAIDYLSEKGFDPQFGARPVKRVIQREVLNQLSKEILAGKITTDSIILLDAFDGQLVFRNQSETEEV
>NZ_CP017774.1|WP_071183307.1|127515_128718_+|IS256-family-transposase
MIDKDDLLNNKDFYKSFKNAEDLTSFFQTMHKRAVEHMLEAELDAHLDNEKHDKTTKGNYRNGHGTKKIKTSFGQQEIKVPRDRDSSFNPLLVPKRENIAQGIENVIISLYAKGMSVSDIEEQIKEVYDFEVSSSTISRITNTITNEVVTWQNRPLEELYLIVWMDGIVFKVREGSKVINKTIYLAVGLNRDGKKDVLGMWLGKNESSSFWMSVLTDLKARGVEDILITATDNLNGFTQTIRSVFPESQTQICVVHQIRNACKYVVWKDRKQFTADMKHIYNVPTKQAAELALNDFADKWESKYSYAIKSWRDNWDELTVFFDFPIEIRKIIYTTNLIENLNGKIRKYTKNKMSFPTDDAVLKSVFLALREATKKWSMPIQNWGIVLNQFTIIFEKRLRL
>NZ_CP017774.1|WP_071186034.1|129112_130534_-|AAA-family-ATPase
MISSQFYSLLKNKFPFSPTYNQDIFFQKIAIFLTETTNDSIFVLKGYAGTGKTTVISTIVNNLLEINKKYVLLAPTGRAAKVIANYSNKAAFTIHKKIYFPKKNSGGGLSFTLQQNKHKNTIFIVDEASMISDVDSDSKMYANGSLLDDLISYVYSGTNCKMILLGDTAQLPPVNLDISPALDIRTLSMNYNKEVDYIELDEVMRQEESSGILHNATELRELLKDSFITDFQFNVRKFKDIVRLVDGYDIQDAINSAYSNYSIEDTAFIVRSNKRANQYNEQIRSKILDKESELSTGDFLMVVKNNYFWLKESDEAGFIANGDIIEILEIFNIKELYGFKFAKVKIRMVDYPNQIPFETVLLLDTIKSESPSLTYEESNRLYQEVLKDYEGETKFKQFQKVKANEYFNGLQVKFSYAITCHKSQGGQWNTVFIEQPYLPNGIDRDYIRWLYTAMTRAKNKLYLIGFKDESFVD
>NZ_CP017774.1|WP_071183308.1|130859_131666_+|DUF3822-family-protein
MDITEKKYKKLSIQVSLTGLSFCCFDTLNNTVSSFKEIHFDHFDKNLKIEDLFANAFAEHTELNEQYDDVLVIHNNNLSTFVPTPLFDENYLGSYLQYNTKVFETDFFAFDEISNYEINAVYIPYVNMNNFFIDKFGSFEYKHANSILVTKLLDASKNVDTKKMMVHFNSTHFEIVVIQNQKLLLFNSFEYQTPEDFIYYILFTAEQLNMNPENFPLELIGNITTESPFFKIAYKYIRNVSLLDVEDLRWNNYFSEAENRNHFILFNS

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Crispr_ID: NZ_CP017774_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017774_2

1476109-1476233

Orphan

Consensus_repeat	Method
GGTTCGAGTCCGCCGCGGCGGAGGAGCTTTTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017774_2

>merge|NZ_CP017774|2|1476109-1476233|CRISPRCasFinder
GGTTCGAGTCCGCCGCGGCGGAGGAGCTTTTTTAAAGAAATCCAGTTTATTCATTTAGACTGGATTTTTTGTTTTAAAAATATTTCGAACCCGGTTCGAGTCCGCCACGGCGGAGGAGCTTTTTT

>NZ_CP017774|2|2|1476109-1476233|CRISPRCasFinder
GGTTCGAGTCCGCCGCGGCGGAGGAGCTTTTTT	AAAGAAATCCAGTTTATTCATTTAGACTGGATTTTTTGTTTTAAAAATATTTCGAACCC
GGTTCGAGTCCGCCACGGCGGAGGAGCTTTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017774.1\|WP_035661941.1\|1489694_1490138_-\|dehydratase	unknown	unknown	gnl\|CDD\|239530
NZ_CP017774.1\|WP_071184301.1\|1474126_1475470_+\|RIP-metalloprotease-RseP	unknown	unknown	gnl\|CDD\|272878
NZ_CP017774.1\|WP_071184292.1\|1462050_1464012_-\|transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|376415
NZ_CP017774.1\|WP_071184306.1\|1480390_1482376_-\|glycoside-hydrolase-family-97-protein	unknown	unknown	gnl\|CDD\|371140
NZ_CP017774.1\|WP_071184298.1\|1470279_1471494_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340951
NZ_CP017774.1\|WP_071184293.1\|1464288_1464864_+\|PorT-family-protein	unknown	unknown	gnl\|CDD\|372635
NZ_CP017774.1\|WP_071184295.1\|1465773_1467396_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173809
NZ_CP017774.1\|WP_071184299.1\|1471736_1472780_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|183212
NZ_CP017774.1\|WP_071184303.1\|1477247_1478246_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017774.1\|WP_071184296.1\|1467656_1469531_+\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341067
NZ_CP017774.1\|WP_071184307.1\|1483852_1485532_-\|glycoside-hydrolase-family-28-protein	unknown	unknown	gnl\|CDD\|227721
NZ_CP017774.1\|WP_071184300.1\|1472905_1473973_-\|NADH:flavin-oxidoreductase/NADH-oxidase	unknown	unknown	gnl\|CDD\|239242
NZ_CP017774.1\|WP_083382058.1\|1488372_1489674_-\|L-fucose:H+-symporter-permease	unknown	unknown	gnl\|CDD\|340952
NZ_CP017774.1\|WP_071184308.1\|1485785_1488212_-\|glycoside-hydrolase-family-2-protein	unknown	unknown	gnl\|CDD\|225789
NZ_CP017774.1\|WP_071184302.1\|1476343_1477171_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|380207
NZ_CP017774.1\|WP_071184305.1\|1478748_1480023_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226702
NZ_CP017774.1\|WP_071184297.1\|1469619_1470237_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017774.1\|WP_071184294.1\|1464987_1465617_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378936
NZ_CP017774.1\|WP_071184304.1\|1478310_1478742_-\|response-regulator	unknown	unknown	gnl\|CDD\|381108
NZ_CP017774.1\|WP_157499569.1\|1482546_1483731_-\|pectate-lyase	unknown	unknown	gnl\|CDD\|312856

Protein	Function_ID	Function_description	E-value
NZ_CP017774.1\|WP_035661941.1\|1489694_1490138_-\|dehydratase	gnl\|CDD\|239530	cd03446, MaoC_like, MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.	3.64373e-48
NZ_CP017774.1\|WP_071184301.1\|1474126_1475470_+\|RIP-metalloprotease-RseP	gnl\|CDD\|272878	TIGR00054, Putative_zinc_metalloprotease_slr1821, RIP metalloprotease RseP. Members of this nearly universal bacterial protein family are regulated intramembrane proteolysis (RIP) proteases. Older and synonymous gene symbols include yaeL in E. coli, mmpA in Caulobacter crescentus, etc. This family includes a region that hits the PDZ domain, found in a number of proteins targeted to the membrane by binding to a peptide ligand. The N-terminal region of this family contains a perfectly conserved motif HEXGH as found in a number of metalloproteinases, where the Glu is the active site and the His residues coordinate the metal cation. Membership in this family is determined by a match to the full length of the seed alignment; the model also detects fragments as well matches a number of members of the PEPTIDASE FAMILY S2C. The region of match appears not to overlap the active site domain. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.31846e-46
NZ_CP017774.1\|WP_071184292.1\|1462050_1464012_-\|transglycosylase-domain-containing-protein	gnl\|CDD\|376415	pfam00912, Transgly, Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.	1.31464e-58
NZ_CP017774.1\|WP_071184307.1\|1483852_1485532_-\|glycoside-hydrolase-family-28-protein	gnl\|CDD\|227721	COG5434, PGU1, Endopygalactorunase [Cell envelope biogenesis, outer membrane].	1.06586e-73
NZ_CP017774.1\|WP_071184298.1\|1470279_1471494_-\|MFS-transporter	gnl\|CDD\|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.75039e-99
NZ_CP017774.1\|WP_071184293.1\|1464288_1464864_+\|PorT-family-protein	gnl\|CDD\|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	1.3119e-17
NZ_CP017774.1\|WP_071184295.1\|1465773_1467396_+\|S8-family-serine-peptidase	gnl\|CDD\|173809	cd07483, Peptidases_S8_Subtilisin_Novo-like, Peptidase S8 family domain in Subtilisin_Novo-like proteins. Subtilisins are a group of alkaline proteinases originating from different strains of Bacillus subtilis. Novo is one of the strains that produced enzymes belonging to this group. The enzymes obtained from the Novo and BPN' strains are identical. The Carlsburg and Novo subtilisins are thought to have arisen from a common ancestral protein. They have similar peptidase and esterase activities, pH profiles, catalyze transesterification reactions, and are both inhibited by diispropyl fluorophosphate, though they differ in 85 positions in the amino acid sequence. Members of the peptidases S8 and S35 clan include endopeptidases, exopeptidases and also a tripeptidyl-peptidase. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin.. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	5.90722e-115
NZ_CP017774.1\|WP_071184299.1\|1471736_1472780_-\|oxidoreductase	gnl\|CDD\|183212	PRK11579, PRK11579, putative oxidoreductase; Provisional.	3.03781e-94
NZ_CP017774.1\|WP_071184306.1\|1480390_1482376_-\|glycoside-hydrolase-family-97-protein	gnl\|CDD\|371140	pfam10566, Glyco_hydro_97, Glycoside hydrolase 97. This domain is the catalytic region of the bacterial glycosyl-hydrolase family 97. This central part of the GH97 family protein sequences represents a typical and complete (beta/alpha)8-barrel or catalytic TIM-barrel type domain. The N- and C-terminal parts of the sequences, mainly consisting of beta-strands, form two additional non-catalytic domains. In all known glycosidases with the (beta-alpha)8-barrel fold, the amino acid residues at the active site are located on the C-termini of the beta-strands.	1.14697e-94
NZ_CP017774.1\|WP_071184296.1\|1467656_1469531_+\|M1-family-metallopeptidase	gnl\|CDD\|341067	cd09604, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains bacterial M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	1.41237e-140
NZ_CP017774.1\|WP_071184300.1\|1472905_1473973_-\|NADH:flavin-oxidoreductase/NADH-oxidase	gnl\|CDD\|239242	cd02932, OYE_YqiM_FMN, Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing agent. The YqjM enzyme exists as a homotetramer that is assembled as a dimer of catalytically dependent dimers, while other OYE members exist only as monomers or dimers. Moreover, the protein displays a shared active site architecture where an arginine finger at the COOH terminus of one monomer extends into the active site of the adjacent monomer and is directly involved in substrate recognition. Another remarkable difference in the binding of the ligand in YqjM is represented by the contribution of the NH2-terminal tyrosine instead of a COOH-terminal tyrosine in OYE and its homologs.	0
NZ_CP017774.1\|WP_083382058.1\|1488372_1489674_-\|L-fucose:H+-symporter-permease	gnl\|CDD\|340952	cd17394, MFS_FucP_like, Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.95578e-139
NZ_CP017774.1\|WP_071184308.1\|1485785_1488212_-\|glycoside-hydrolase-family-2-protein	gnl\|CDD\|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	3.31341e-61
NZ_CP017774.1\|WP_071184302.1\|1476343_1477171_-\|ATP-binding-protein	gnl\|CDD\|380207	NF033206, ScyE_fam, ScyD/ScyE family protein. This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.	0.00754196
NZ_CP017774.1\|WP_071184305.1\|1478748_1480023_-\|PAS-domain-containing-protein	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	1.11996e-77
NZ_CP017774.1\|WP_157499569.1\|1482546_1483731_-\|pectate-lyase	gnl\|CDD\|312856	pfam09492, Pec_lyase, Pectic acid lyase. Members of this family are isozymes of pectate lyase (EC:4.2.2.2), also called polygalacturonic transeliminase and alpha-1,4-D-endopolygalacturonic acid lyase.	4.12408e-146
NZ_CP017774.1\|WP_071184294.1\|1464987_1465617_+\|hypothetical-protein	gnl\|CDD\|378936	pfam12729, 4HB_MCP_1, Four helix bundle sensory module for signal transduction. This family is a four helix bundle that operates as a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterized in E coli chemoreceptors.	0.000276049
NZ_CP017774.1\|WP_071184304.1\|1478310_1478742_-\|response-regulator	gnl\|CDD\|381108	cd17557, REC_Rcp-like, phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains. This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.69556e-27

>NZ_CP017774.1|WP_071184301.1|1474126_1475470_+|RIP-metalloprotease-RseP
MEIIIKLSQFLLSLSLLIILHELGHFIPAKLFKTRVEKFYLFFDVKYSLLKKKIGETEYGIGWLPLGGYVKISGMIDESMDKEQMALPPQPWEFRTKPAWQRLIIMLGGVTVNFILAFIIYIGMAFVYGDTYIANSDMKDGLLIESPAMIKAGFKTGDKILAVDGTKIIKFDNTIDLKIAMAKEVLIERNGAQQTIKMPNDIVDQLSKYKKGPIVGIRMPFVIGAVTEESKNTALKSKDIVLTLNGQKTKYFDEAKTILDNNKGKTIPAVVLRNQKETTVPVIVNNEGKLGVQIGGLNLDSLEKLGYYKISTQKYGLFESIPAGLEKGKNQLISYGAQLKMIFNPETKAYKQVGGFAAIFNIFPNTWSWEAFWNITAMLSIMLGVMNLLPIPALDGGHVMFLLYEIVSGKKPSDKFLENAQMVGFVLLITLLLFANGNDIYKAVVGK
>NZ_CP017774.1|WP_071184300.1|1472905_1473973_-|NADH:flavin-oxidoreductase/NADH-oxidase
MASPLFSPIKIKDCTLKNRIVISPMCQYSSEDGFANDWHLVHLGSRASGGAGLIIQEATAVAPEGRISPEDLGIWKDEHIEKMKAITAFIKSQNAVPGIQLAHAGRKASVSSPWKGNKKLDASQGGWQTVAPSAIGYHDDETPVALDKKAIHQLISDFKAATKRAVQAGYEVLEIHAAHGYLNHQFLSPLSNTRTDEYGGSFENRIRFTIEVLEAVQTEWPEHLPLFVRISATDWAEGGWNVEESIEFSKILKEKGVDLIDVSSGGLVSHQKIPLEAGYQVPFAEKIKKETGILTGAVGLITEASHAEEILTSEKADLVLFARASLRDPNLGLNFAKALATDVAWPSQYERAKPR
>NZ_CP017774.1|WP_071184299.1|1471736_1472780_-|oxidoreductase
MKTIKAALLSYGMSGKVFQAPFLELHPGFELLGSWERSKKLIQEDYPQVKSYASLEEILANDTIDLVVVNTPIDTHFEYAKRVLEAGKHAIVEKAFTTTVAEADELADLAKEKGLKLAVFQNRRWDSDLKTVRQILLDGALGEIVEAEFHFDRYNPLLSPKQHKETVNSGSGILKDLGPHLIDQALYLFGFPKAVFADIRTTRENSVVDDWVDVLLYYPDFRVRLKASFFVREPNPAYVIHGKKGSFLKPRGDVQEDDLKVMKKPNLDSWGTEPLEKEGFLHTEIDGKIMHGKIPTLKGNYYDFFDGVYNAIINDTVEPVTAQDGARVMQIIEAAIQSSQEKRVVDL
>NZ_CP017774.1|WP_071184298.1|1470279_1471494_-|MFS-transporter
MLRLNFIGSFRAQGKIKKSFRNAKLSYLNRVRIAVSSFYFGMGLCFATWASRIPDIRVALQLSDADLGSILFALPVGQLTMMAFSGKLVTRFGSHRLVVLSLSMYAFCLTNLGLATTAWQLALGLYVFGIFGNMNNIAVNTQGVYTEQLFKRTIMASFHGVWSFAGFTGALVGLGMLALNLTPYHHFIVVGIITALLIIFNYKFLVKAKEKRKAPEKKKLFSKPDSALIWLGIIGFGSMASEGIMFDWSGLYFKDIVQAPGPLIILGYTSFMIMMATGRFLGDGMINKFGRKTVLQTGGILISTGLFTAVFLPFLIPSTIGFMLVGLGVSTIVPTLYSIAGKHPTIPPGEALTAVSSVSFLGFLMGPPVIGYIAELFGLRFSFAFIGVFGILIALLVPRIKVIQ
>NZ_CP017774.1|WP_071184297.1|1469619_1470237_+|hypothetical-protein
MKALLYFILILTLQSCATKKYIKTQLLPEGIKSATEETYKVVDNEQQLLQKKEMIFTANGRIKHSKTVDAEGNIIQETKKKLWFIVELYPGKETYYCKTRWKPGQRERISCYTRKQYKENESIYHYNADGTIDKIVDNFTTFYTQYFYYSNNELSRIVVKDKNNQLIDEILIRCESKDEKGACLKETRISIITKNKEVRQLSANY
>NZ_CP017774.1|WP_071184296.1|1467656_1469531_+|M1-family-metallopeptidase
MKKILLTACIVWNSFSLFAQNTSYWQQKADYKMDVFMDTERFQYKGKQELIYTNNSADTLKKVYYHLYNNAFQPGSEMDSRAQNIKDSDARMVTKTKIDGTEVKQSRIKSLKPNEIGYLNISNFKQDGVAAKTKTTGTILEVFLAKPILPHSTTTFTLNFDGQLPVQIRRSGRNNSEGVALSMAQWYPKIAEFDFEGWHPDPYIAREFHGVWGNFDVKITIDKNYVLGATGYLQNPNEIGHGYQETGVEVKHPKKTKNLSWHFVAPMVHDFTWAADKEYLHDVVKGPNDVDLHFLYKNNPKIIENWKNVQPLMVKVMDLYNKHIGNYPYKQYSFIQGGDGGMEYAMCTLILGNGTLEGIFGTATHELGHSWFQHVLASNESKHAWMDEGFTTYVQNLVTNEMAAKKVQNPFKQNYVLYTDLVNSGKEQPQTTHSDRYDENRPYSISSYIKGSIFLSQLGYLIGQDKLAETIKRFYQDFKFKHPIPNDIKRTAERVSGAELDWYLTDWTQTTNTIDYGITAVTENDKNTVVNLERIGRMPMPIDLQVEYVDGTVESFYIPLRMMYFEKENPNPDVKRTVLSDWAWANPKYEFNIGKPKSTIKKITIDPSGLMADVKMTNNVFEMK
>NZ_CP017774.1|WP_071184295.1|1465773_1467396_+|S8-family-serine-peptidase
MNTVKPIFLSLLSALILAGCGAQKTSNYKSFTPITEIGSIAKKKPLTETELKRWSHYDIIKDTVPGMSVDRAYAELLQKRKSKKVIVGIVDSGVDIEHEDLKSIIWTNPKEIPGNGIDDDKNGYVDDIHGWNFLGDITKENLEYERIVKDKSIADEATYQAAKKFNDKVVAEAPLYKKHYTKLLNDMQEADKIIAQQLAKSVYTAADLDAIASEDQLVQKSKMVMKQMFSYGMSIKGLEDTFKKEIEKNESIINGDNLKPDYRKVLGDNPNDITNNSYGNNNVIGPDKDEALHGTHVAGIVAQLRNNNIGGDGIADNVAILTVRAVPDGDEYDKDIALAIRYAVDNGAKVINGSFGKAFSPHKNWVFDAIKYAAEKDVLIVHAAGNDAKNIDYFDNFPNDSEDRKTEFSDNLITVGALNFEYGSNIVAGFSNIGKINVDVFAPGVKIYASIPNNEYKFLKGTSMAAPNVAGVAALIRSYYPKLKAAQVKQILMESGVAINKEVVVGGNAKDIRPFNELSKTGKIVNAYNAILMANAMAKK
>NZ_CP017774.1|WP_071184294.1|1464987_1465617_+|hypothetical-protein
MKDINRINRNTKAAAVLIFVTILLLISNYFMGLNSKKTNETIKAIYNDRLMVSHYVFQYTHAIYQIKETANTLKIIDFEKQQFILSRLKTIHQIDKKYLKTILTPDEKKQFRIFQNQCIAIQTQNKDKNWQKMSLLSEQSLGSLAILARIQVDEGKTALIIANALHDGNQFFAQFEIALYIILACLSAYLLVLKKMKVKIKIPENPSMN
>NZ_CP017774.1|WP_071184293.1|1464288_1464864_+|PorT-family-protein
MKKVILSVVAVLAFAFTNAQETKETVKLGVKAGANYDWLSTGAASVYDLRPEVGYHAGLVAEFKFCDAFSIQPEALYSFSKYSFDGNGNTSGNEIEISEIAVPVIAKFYLVKGLSLELGPQASVIVKTKLTGEDAEANFRKYNIAAATGLAYDFNMGAFIQARYTYNFLDLQHGANGNNRFGIQASVGYKF
>NZ_CP017774.1|WP_071184292.1|1462050_1464012_-|transglycosylase-domain-containing-protein
MKTRRQKIILVAKILVAFLFVTIIGLFSFREMLLQQIITKTANKMEVDYNSHFVVKKAAFEGLSCINLTDITLVPKNADTLFNIQRMRTSVNIWRLFVGDVQLGTLEIKNGYVQLTKKGKVKNFAAFLKRNKDEEQSSDKRDYAAFAYRIISKVLHLIPTDMEVENLKFKLDDNGKRATIDIKKLVLANKELETSIHVKTNTFAQRWKIKGFADPRNKKADIRFFNIDTGAIKVPYFDERYNLISSFDSIRLNIENIDKSGGELHIDGFTSIANLKINHAKIARKDVLIKNARFDYRLLLGSDFVSVDSSSTVQFNRIKLHPYLAYETEEDTIYRLKVNIPKMKAQDFITSLPDGLFTNFQGMEAKGTFDYNLDFKYNKNKANDLVFNSNLKKENLKITKYGEANLTKLNSEFIYRAIINGVMQRPVLVGTANVNYTPLDQISPYLQKCVLTTEDPSFFSHHGFINEAFKQSIAKNIRTRKFARGASTISMQLIKNVFLTREKTLSRKLEEILLVYILENNRIVSKERMLEVYFNIIEWGPNVYGIGEAAQFYFQKTPADLTFNECLYLARIIPSPKKFMYQFNDEGNLRESAVKQVSFLTDLMIRRGLLTIDDTIFKSQATILTGPAKSLLRIKVKDTTAVDSLAVKEEFEF
>NZ_CP017774.1|WP_071184302.1|1476343_1477171_-|ATP-binding-protein
MKYKFLSLSAFIILSFTTKAQQLSKPIWESKNLRVPESVLYSAADKKLYVSLIDGAGNVKDGKGGIAVLDTDGSVKNANWIEGLNAPKGLVRFKNTLFVADIDAVVSIDILTGKIIDKVAIENAVFLNDVTVDDKGVVYVSDTRTNKIHRIKNGQSELYLENVTNANGLKWINKNLYVLANTELLKIDKNKNRTVVAKGFEKQGDGVEQLKNGDFIVSCWAGLIYYVKANGEISKLQDVQGQMNTADLGYNPKENILYIPTFNHNSVIAYKLLAD
>NZ_CP017774.1|WP_071184303.1|1477247_1478246_-|hypothetical-protein
MKKLFPILLLLGSINLFSQNLVEDFEIQIQNRGLKSNFNKIIVLDSRLDTTNVGVIQKGAFNRKAFLKAKVPLNHQIENVFKALIQSDAKEGELVLNLRDYKFTEITEAFSETGYCYLRADLFVKKESGYEKIDFIDRVFEVNAMDVTKKNIRNGSEKLIQFIEGNLMSFKIGEAYTFDEIKNISNIEKRKTPVYNTNIYVDGIYKDFESFKNQIPSSREYKVTRNKKNVITKLEGVSDGVAFKVDTDFIYCLIDQGKIYLIQKNLFVPVEFKDDDFYFKGRAKVTAKTGDVVLASAFFGIIGGALASNATSEFLMKIDHQNGATVQVTELK
>NZ_CP017774.1|WP_071184304.1|1478310_1478742_-|response-regulator
MKKKLNCVLLVDDDKGTNFINQMIIKKADVAERIQTVLNGREALDFITNKGKYESAGDVFPQPMLTLLDINMPVMDGWEFLEAYHALEEHQKGKIIIVMLTTSLNPDDKTRAEGISEVSDFKNKPLSHEAFADIIKTHFPECF
>NZ_CP017774.1|WP_071184305.1|1478748_1480023_-|PAS-domain-containing-protein
MKTHTVDFQKVFLSAPSLFLILSTDFTILDLNDSYEKATMKKREEMIGRNLFEVFPDNPNDKLADGVSNLSQSLHSVLKEKKRHVMAVQRYDVQGPDGVFEERYWSPVNIPILNSENEMDCIVHRVEDVTEFVILKDEQLKSKNQTENLQKKVDEMEVEIIKRSREIQKMNFELEQKVRERTETLLKREALLAEQNRKLKEQNKELEQFTYITSHDLQEPLRSLISFTELLQKEFAGTLDGNGNLYIDFISQSSRRMQALVKGLLDYSRIGRKKELVEVDCNQIVDEVLSDITLTITESKAKINVGNLPQIKGYSTELRQLFQNLISNAIKFRKKEVLPEIRISAQEQENDWLFSVQDNSIGIESKDMHKLFVIFKRLHDRDEYEGTGIGLAHCKKIVELHCGSIWADSKLGEGSTFYFTIPKF
>NZ_CP017774.1|WP_071184306.1|1480390_1482376_-|glycoside-hydrolase-family-97-protein
MTISVLNHLKLINFKFFFHLFLFSFFVANAQSQQVAVNSPDGKLTVNLAVNNGTPTYSVSYKGKLFLEPSPIGLKTNIGDFSTGLELKANQVQNKIDETYELPNIKQSKVHYVANEAIFSFTKDNKEVIDIIFRVSNNDVAFKYKVYPQKSTVAAVVQEEASGFLFPAGTTSFLSAQSKAMVGWERTMPSYEIPYVVDAPVGENGKGEGYTFPCLFKLKNNGWVLISETGVDSYYCASRLIGHEKGLYTIGFPMQGENNGVGSSTPGIRLPGETPWRTITVGETLEPIVTTTVPFDVVKPRYEASQKYQYTKGTWSWIIGMEKSMNYDEQLRYIDFSADLGYETLLVDALWDTQVGRDKVEALAKYGASKGVGLYLWYNSNGYWNDAPQTPRGKMDNSIVRRKEMAWMKSIGIKGIKVDFFGGDKQETMKLYEDILFDANDYGIMVIFHGTTLPRGWERMYPNYASSEAVLASENLFFTQESNNLEAFSATLHTFIRNTVGSMDFGGSALNKFYNDKNTPNKGSKRLTSDVYALATAVLFQSGVQHFALAPNNLTDAPKWAIDFMKAVPTIWDEVRFIDGYPGKYAILARRHGDKWYVAGINAQKETVKLKIKLPMIAGGTELKQYADDAQLNGKLTTTKLKKNQEIEVTIPCNGAVVLVN
>NZ_CP017774.1|WP_157499569.1|1482546_1483731_-|pectate-lyase
MNPTKKNYLALLMVFALATTFVNAQSDKKAADISTKPFGDSERHWYGIKDESNLVNPVPNQPKYPESDYTKIADNMILFQCANGGWPKNYDMKAILTPEQVEKVASTKAILHTTFDNETTYTHVYYLAQVYTATKIEKYKVACEKGIQFILDAQYANGGWPQYFPLEKNYSRHITFNDGAYMGIINLLDKIVNNNPNFSFLDEALRAKVTQAYNKGIDCILNMQIKDKGRLTAWCQQHDEETLAPAWARKFEPPSICNAESVGVVLFLMKIKNPSDRIIQSIQSAVKWFADSKIYNTRVESFEIEAFESKYKTVKRDVRVVADAVAPPIWTRYYELGTNKPLFSDRNSELLYSLAEVSVERRSGYAWYTYEPQKALDKYAEWQQKYAPSDNVLK
>NZ_CP017774.1|WP_071184307.1|1483852_1485532_-|glycoside-hydrolase-family-28-protein
MKNKSRNFLFAAFVIMLSGWSQNSAAQNSNSEEFYQGIEFKMAKVQEPKIPNNTVNIKDFGAVNGGYVLNTKAFADAIDAVSQKGGGKVIIPPGIWLTGPIILKSNLELHAERGALIKFSTDKSLYPLVETSFEGLNTWRCISPLYGKNLENVAFTGNGVWDGSGEVWRQVKKAKLTESQWKKFVASGGVLNESKTSWYPSEVFMKASVGADQNVRLDLKTKEDFEKIHDFLRPVLVSIQNSKRVLFDGPVFQNSPAWNIHPLMVEDLIVRNVTVRNPWFSQNGDGLDVESCKNVIVENSSFDVGDDAICIKSGKDKDGRDRAVPCENLIIRNNIVYHGHGGVTVGSEMSSGVKNMHVSNCSFIGTDVGLRFKSNRGRGGVVENIFISDIFMTDIPSQAISFNLYYGGKSIAETLEEGGTPVENKMVPVDEKTPQFKNISMKNITIAGAQQAVFLQGLPEMNLENISISNLLAKADKGVTIVDATGIKISDAKFDIKESNVFDIYNVKNSSLKNVEINSTSPKAVTINGAASENIDLTSSNLSKKTFIGEKVPKKAVKL
>NZ_CP017774.1|WP_071184308.1|1485785_1488212_-|glycoside-hydrolase-family-2-protein
MTQFRIFLFTFFIITQISLAQVRTVRELDSNWKFQKGDFENAPQTNFNDSKWEKVSVPHDWAIYGPFDKEIDKQSVAIVQNGEKVASEKTGRTGALPHIGTAWYRNKFTISAAEKGKKVILLFEGAMSEPQIYLNGKKVGEWAYGYSYFYFDITDFISAGENTLAVKLTNKEFASRWYPGAGLYRKVSLIIKNKESIDQWGTTITTPFISKEVAKVNVKTKATGEKGYLVTTIFDANGQKLSSDKATTKFGNEFDQNIKVDNPKLWSPESPYLYKAVSQWFVGDQLKDEVTTRFGIRDIKYEANKGFSLNGEVRKFKGVCLHHDLGPLGTAINVAALRRQLTILKDMGCNAIRSSHNMPSLEQLELCDEMGFMFLAESFDEWAKPKVKNGYNRFFEAYAEKDLVNLIHATRNHPSIVMWSSGNEVPDQWGEAGVKRAKWLQEIFHREDPTRPVTVGMDQVKATMESGFGALLDVPGLNYRVHLYEEAFKKFPQGFILGSETASTVSSRGIYKFPVVKEKNKQYPDFQSSSYDLEACSWSNVPDEDFVLQDDKPWVIGEFVWTGFDYLGEPTPYDEKWPSRSSYFGISDLAGLPKDRFYLYRSRWNTEKETLHILPHWNWEGREGQVTPVFVYTNYDSAELFVNGKSMGIQKKNNTTPQNRYRLMWMDVKYEPGTLKVVAFDKNGKAVAEEEIHTAGKGYQIVLDADRKTIKADGKDLSYVTVSVVDKNGVPCPTLTNQLQFKVKGKGTYKAACNGDATSLEQFHLPTMKLFSGKLVVTVQSLKEAGNMELTVTGKGLKTATLSISSTN
>NZ_CP017774.1|WP_083382058.1|1488372_1489674_-|L-fucose:H+-symporter-permease
MQVTNQLGDQHSVPTEKGQGPNYVLPFILITSLFFLWGMAHNLDSILIPHLKKACQLNNRQSTLIDTSVFLAYFLMAIPAGMIIKKVGYKNSIIIGLLVFAAGAFLFVPAANSQAYELFLVALFIIGCGLTILETSANPYAAILGPPESASKRLNLAASFNGLAAMVAPIVGSLFILSGKSYTPEQMAAMPEAERLSYLAGEAAAVKMPYIVLGTILVLVAILFYFMHLPSMKPEHIEVEVKPGFFSVLKHRHLSWAVVAQFFYVGAQVCVTSFFIRMAEQGANMDEITAAYYLGLYGVLFMAGRFIGTFFLKYVKDYVLLSIYAALSTILCAVAIYGTGIYVIYALGAIGFFMSIMFPTIFSLGLVGLKSNTETGSSWLVMAIVGGAILPYGMGTLIDMNHDDIQSGYLIPLVCFLIILYFGVFGHKVKKVA
>NZ_CP017774.1|WP_035661941.1|1489694_1490138_-|dehydratase
MYFKSTFFEDYQLGEKRVTLGRTITETDFVVHAGHTGDFFPHHMDEEWCKTQPFGQRIAHGTMVLAIGVGLTASEINPEAFSKGYDRMRFVKPVHIGDTIHSEITISEKGDAKRPEMGTVTEHLEIINQRGEVVMVCDHLLLVKRKN

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Crispr_ID: NZ_CP017774_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017774_3

1812015-1812219

Orphan

Consensus_repeat	Method
CTGATAAAGATGATGCTTGTCCTAATGTTGCTGGTCC	PILER-CR

2 spacers

WYL

The CRISPR arrays of NZ_CP017774_3

>merge|NZ_CP017774|3|1812015-1812219|PILER-CR
CTGATGCAGAAGATGCTTGTCCTAATGTTGCTGGTTTAGCTTCTTTAAAAGGTTGTCCGGATGCTGATAAAGACGGTGTAGCTGATAAAGATGACAAATGTCCTAATGTTGCTGGTCCTAAAGAAAACGCAGGTTGTCCTTGGCCAGATACTGATAAAGATGGTGTAGCTGATAAAGATGATGCTTGTCCTGAAGTTGCTGGTCC

>NZ_CP017774|3|1|1812015-1812219|PILER-CR
CTGATGCAGAAGATGCTTGTCCTAATGTTGCTGGTTT	AGCTTCTTTAAAAGGTTGTCCGGATGCTGATAAAGACGGTGTAG
CTGATAAAGATGACAAATGTCCTAATGTTGCTGGTCC	TAAAGAAAACGCAGGTTGTCCTTGGCCAGATACTGATAAAGATGGTGTAG
CTGATAAAGATGATGCTTGTCCTGAAGTTGCTGGTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017774.1\|WP_071184550.1\|1804619_1805612_+\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NZ_CP017774.1\|WP_071186216.1\|1807774_1810936_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|224000
NZ_CP017774.1\|WP_071184556.1\|1815459_1816242_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP017774.1\|WP_071184558.1\|1816934_1817453_+\|ferritin	unknown	unknown	gnl\|CDD\|153113
NZ_CP017774.1\|WP_071184547.1\|1800810_1801770_-\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP017774.1\|WP_071184561.1\|1820023_1821316_-\|M24-family-metallopeptidase	unknown	unknown	gnl\|CDD\|238520
NZ_CP017774.1\|WP_071184545.1\|1798977_1800024_-\|thiamine-phosphate-kinase	unknown	unknown	gnl\|CDD\|100030
NZ_CP017774.1\|WP_071184546.1\|1800218_1800701_+\|damage-inducible-protein-DinB	unknown	unknown	gnl\|CDD\|225200
NZ_CP017774.1\|WP_157499572.1\|1806012_1807125_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NZ_CP017774.1\|WP_071184549.1\|1802570_1804367_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP017774.1\|WP_083382069.1\|1818865_1819621_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379523
NZ_CP017774.1\|WP_071184562.1\|1821505_1822867_-\|hydroxymethylglutaryl-CoA-synthase-family-protein	unknown	unknown	gnl\|CDD\|225959
NZ_CP017774.1\|WP_071184553.1\|1807215_1807608_-\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|376719
NZ_CP017774.1\|WP_071184559.1\|1817654_1818098_+\|cyanase	unknown	unknown	gnl\|CDD\|235079
NZ_CP017774.1\|WP_157499507.1\|1802282_1802453_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017774.1\|WP_071184555.1\|1812672_1815435_+\|PD-(D/E)XK-nuclease-family-protein	unknown	unknown	gnl\|CDD\|378929
NZ_CP017774.1\|WP_071184560.1\|1818410_1818872_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379523
NZ_CP017774.1\|WP_071184557.1\|1816491_1816848_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017774.1\|WP_071184563.1\|1823237_1823903_+\|succinate-dehydrogenase-cytochrome-b-subunit	unknown	unknown	gnl\|CDD\|239578
NZ_CP017774.1\|WP_071184548.1\|1801927_1802293_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350305

Protein	Function_ID	Function_description	E-value
NZ_CP017774.1\|WP_071184550.1\|1804619_1805612_+\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	3.59417e-118
NZ_CP017774.1\|WP_071186216.1\|1807774_1810936_+\|AAA-family-ATPase	gnl\|CDD\|224000	COG1074, RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair].	8.30715e-81
NZ_CP017774.1\|WP_071184548.1\|1801927_1802293_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350305	cd18738, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.71827e-24
NZ_CP017774.1\|WP_071184558.1\|1816934_1817453_+\|ferritin	gnl\|CDD\|153113	cd01055, Nonheme_Ferritin, nonheme-containing ferritins. Nonheme Ferritin domain, found in archaea and bacteria, is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The ferritin protein shell is composed of 24 protein subunits arranged in 432 symmetry. Each protein subunit, a four-helix bundle with a fifth short terminal helix, contains a dinuclear ferroxidase center (H type). Unique to this group of proteins is a third metal site in the ferroxidase center. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite.	1.63004e-54
NZ_CP017774.1\|WP_071184547.1\|1800810_1801770_-\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.04074e-55
NZ_CP017774.1\|WP_071184561.1\|1820023_1821316_-\|M24-family-metallopeptidase	gnl\|CDD\|238520	cd01087, Prolidase, Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.	8.15705e-89
NZ_CP017774.1\|WP_071184545.1\|1798977_1800024_-\|thiamine-phosphate-kinase	gnl\|CDD\|100030	cd02194, ThiL, ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the conversion of this intermediate to thiamine pyrophosphate. The N-terminal domain of ThiL binds ATP and is related to the ATP-binding domains of hydrogen expression/formation protein HypE, the AIR synthases, FGAM synthase and selenophosphate synthetase (SelD).	2.5062e-109
NZ_CP017774.1\|WP_071184546.1\|1800218_1800701_+\|damage-inducible-protein-DinB	gnl\|CDD\|225200	COG2318, DinB, Uncharacterized protein conserved in bacteria [Function unknown].	4.19583e-14
NZ_CP017774.1\|WP_157499572.1\|1806012_1807125_-\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	5.70105e-37
NZ_CP017774.1\|WP_071184549.1\|1802570_1804367_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP017774.1\|WP_083382069.1\|1818865_1819621_+\|hypothetical-protein	gnl\|CDD\|379523	pfam14253, AbiH, Bacteriophage abortive infection AbiH. This family of proteins confers resistance to bacteriophage.	1.38972e-14
NZ_CP017774.1\|WP_071184562.1\|1821505_1822867_-\|hydroxymethylglutaryl-CoA-synthase-family-protein	gnl\|CDD\|225959	COG3425, PksG, 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism].	2.25419e-76
NZ_CP017774.1\|WP_071184553.1\|1807215_1807608_-\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|376719	pfam02033, RBFA, Ribosome-binding factor A.	6.25057e-30
NZ_CP017774.1\|WP_071184559.1\|1817654_1818098_+\|cyanase	gnl\|CDD\|235079	PRK02866, PRK02866, cyanate hydratase; Validated.	8.99966e-80
NZ_CP017774.1\|WP_071184555.1\|1812672_1815435_+\|PD-(D/E)XK-nuclease-family-protein	gnl\|CDD\|378929	pfam12705, PDDEXK_1, PD-(D/E)XK nuclease superfamily. Members of this family belong to the PD-(D/E)XK nuclease superfamily.	5.63256e-21
NZ_CP017774.1\|WP_071184560.1\|1818410_1818872_+\|hypothetical-protein	gnl\|CDD\|379523	pfam14253, AbiH, Bacteriophage abortive infection AbiH. This family of proteins confers resistance to bacteriophage.	2.39122e-07
NZ_CP017774.1\|WP_071184563.1\|1823237_1823903_+\|succinate-dehydrogenase-cytochrome-b-subunit	gnl\|CDD\|239578	cd03498, SQR_TypeB_2_TM, Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. C. glutamicum SQR reduces low potential quinones such as menaquinone. SQR is also called succinate dehydrogenase (Sdh) or Complex II and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are classified as Type B as they contain one transmembrane subunit and two heme groups. The heme and quinone binding sites reside in the transmembrane subunit. The transmembrane subunit of members of this subfamily is also called Sdh cytochrome b558 subunit based on the Bacillus subtilis protein. The structural arrangement allows efficient electron transfer between the catalytic subunit, through iron-sulfur centers, and the transmembrane subunit containing the electron acceptor (quinone). The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes. Proteins in this subfamily from G. metallireducens and G. sulfurreducens are bifunctional enzymes with SQR and QFR activities.	8.18357e-62
NZ_CP017774.1\|WP_071184556.1\|1815459_1816242_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.12705e-37

>NZ_CP017774.1|WP_071186216.1|1807774_1810936_+|AAA-family-ATPase
MQRHSFSIYDASAGSGKTYALVKEYLKIILVAPKNDAYRNILAITFTNKAVHEMKSRIVGSLSEFAKDEPSKKAQDLMRDLAIDTQLSLIQIKTKSKQIIKHIIHNYAAFDISTIDKFTHKVIRAFAHDLNLPMTFEVTLDTENLLTEAIDAIIAQAGEDETLTKLLIDFTMEKTDDDKSWDISREIMETGKLVLNENNRNEITQFHDKSIAEFVEIKKKLLVVCKDLEKENVAFAEAALILIENNGIDLKSFSRGTFPNHLASIRDGKYNPKNKTFHEFDDIVINKTAKDRALIENLIPELLQILATIYKNFEKRDFYKAFLKNITPLSLLNTVSNELAKIQEEQNVLSISEFNAIIHREIQNQPAPFIYERLGERYRHFFIDEFQDTSEMQWQNLIPLIDNALSGQDDYGEKGTLMIVGDPKQSIYRWRGGKAEQFIELSKDNNPFNNPDKKLEHLDKNYRSYSQIIEFNNDFFKLLSSEFEHPDYKDLYENHSHQHINDKKGGYVNISFIPKTETAEESEEEVLDKTELYVLATLNTIQKVLKQGFEYKDIVILTRKRSEGIAIASYLTEQNIPLLSSETLMIQNATEVRLIIHLLKYLKNNADLESKANFLHYIAKNIQDQMPVHDFIAKGMQQKQEADFEKWLMSFDISLSFQNIRKKSLYEAVEIIVSKFLSDITSSGNAYVQYFLDIVLERDVRNQAGIADFLIFWDKNGEKFSIPSPEGNNAVRIMTIHKSKGLEFPVVIMPFAEEDYNRKPKDKLWLDAEEMDLGLPKALIDNSSAVEGFGEEAKLVYDQKKQEELLDNVNVLYVALTRAEEQLYVVSNMNLSKKGEIPKNNMCAFFINYLMNKGLFDESKLEYGFGNRIKISSETKHIDTSKPIENVAVTLNPKNIKIAQREALMWGTHQQESIEYGNVVHEILSFVKTKKDVDLAVDKAIENGLINSIQKELVYKKIQEIVSHTELELFFAEGNQVLNEQTIVQKKGAVVKPDRMVITQEKAVFLLDYKTGIPNAKYNRQLEDYQYAIEQMGFKVQKKVLVYISEDIQVVGL
>NZ_CP017774.1|WP_071184553.1|1807215_1807608_-|30S-ribosome-binding-factor-RbfA
METNRQKKIGGVIQKDLVDILQGEVRKNGVSNLVISVSKVSVTTDLSVATVYLSIFPQEKAQETLDGIKSNTTLIKHDLAQRVRKQLRRVPNLVFFIDDSLDYIEKIDNALKNQENPIENRDLLEKRRQF
>NZ_CP017774.1|WP_157499572.1|1806012_1807125_-|FtsX-like-permease-family-protein
MGIIVGAMALFVVLSVFSGLKVFSLSFSNDIDPDLKITSTLGKSFFVTPNQEEQIKKIDGVVFYSKIIEERVLFTFDNKQEVTYLKGVDSNYSKVNNVNKIIYNGQWLEDNTYQVVVGFGLVQKLSLGLLDFNKHLEVLVPKAGKGNIENAEEAFNSSEIFPIGIYAINEDLDSKYVFANLDLAQELLEYKPNQISGIELKEKPNVDENAIIEKLNTIFKGKVTVKNRAQLNESLYKMLNTENIAVYLIFTLVIIVALFNLIGALIMMILDKKGNLKTLFNLGTEIKNLRKIFLLQGTLLSFFGGLIGLAIGIIIVLLQQHFEWIMITPTLAYPVVFSIENVLIVMATIITLGFIASLIASSRVSEKLLD
>NZ_CP017774.1|WP_071184550.1|1804619_1805612_+|tRNA-dihydrouridine-synthase-DusB
MIKIGNIELPDFPLLLAPMEDVSDPPFRRLCKMHGADMMYSEFISSEGLIRDAIKSRMKLDIFDYERPVGIQIFGGDEEAMALSSKIVTTVNPDLIDINFGCPVKKVVCKGAGAGVLKDVDLMVRLTKAVIDSTNLPVTVKTRLGWDDNSINIDEVAERLQDIGVQALSIHARTRAQMYKGHSDWSHIARVKNNPRITMPIFGNGDIDSPEKALHYKNEYGIDGIMIGRAAIGYPWIFNEIKHYFKTGEHLAKPTVADRVEAVRNHLTWAMDWKGERLGIVETRPHYTNYFKGIHSFKSYKQKLVTLDHPEELYAVLNEIEEAYSGYELV
>NZ_CP017774.1|WP_071184549.1|1802570_1804367_-|elongation-factor-4
MKKIRNFCIIAHIDHGKSTLADRLLAATQTVTAREEKAQLLDNMDLERERGITIKSHAIQMEYKYKGEEYILNLIDTPGHVDFSYEVSRSIAACEGALLIVDAAQSIQAQTISNLYLALENDLEIIPVLNKVDLPSANPEEVSDDIIDLLGCKLEDIIHASGKTGFGVENILAAIIEKIPAPKGNPEEPLQALIFDSHYNPFRGIEVIFRVVNGEIKKGQKIKFMATGNEYFADEVGTLKLNQVPKNVISTGDVGYLISGIKEAKEVKVGDTITDAKVPTTNMITGFEDVKPMVFAGIYPVDTEDYEDLRSSMEKLQLNDASLVFTPESSAALGFGFRCGFLGMLHMEIIQERLEREFDMTVITTVPNVSYHAFTKKEPDTILIVNNPSDLPEPSKLDRVEEPYIKATIITKADFVGNVMSLCIEKRGLITNQTYLTTERVELNFDMPLAEIVFDFYDRLKTVSKGYASFDYSPIGMRTSKLVKLDVLLNGQNVDALSALIHEDNAYNIGKKMTEKLRELIPRQQFDIPIQAAIGAKIIARETIKALRKDVTAKCYGGDISRKRKLLEKQKKGKKRMRQVGNVEIPQEAFMAVLKLND
>NZ_CP017774.1|WP_157499507.1|1802282_1802453_-|hypothetical-protein
MVLIIKKKNTKKEIDSILEKKEKSASKKGNLSKHFGKLKRNIDGLEYQLETRKNED
>NZ_CP017774.1|WP_071184548.1|1801927_1802293_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MKIDFLADTNFLIYLHEGKPFIEPFLNYNFGISFISEIELLGHKNISKQDEKSLKGLLKDSFVFNFSEDIKLQTIKLKQKYSIKLPDAIIASTSIIFQIPLITSDKGFKSVEELDLILLEN
>NZ_CP017774.1|WP_071184547.1|1800810_1801770_-|YafY-family-transcriptional-regulator
MFDESPKRFDRIVAILIQLQSKKIVKAQELANRFEVSLRTIYRDIRTLEASGVPIYSEAGVGYALMEGYRLPPVMFTREEASSFIAAEKLMQKFTDVTLGNHYASAMYKLKAVLRSDDKDWVSSIESNVLMQTSEKLFNDKSPNTLATIFESIAEKTQVILSYEAIDADGITMRHIEPVGVFHDNNNWYMLGYCHLRKDYRQFRTDRVHGIKKTAIPFSIEHEALETYLDKSKNIPTTKIRILVDKKIAKYLSSERKYHGFVSEKKINNKIEMTFMSCATLEGFSRWYLMFGDYATILEPEGLKTRILELLEINKQRLL
>NZ_CP017774.1|WP_071184546.1|1800218_1800701_+|damage-inducible-protein-DinB
MKTQAAQVITPEDLLQHWQGHRALTRRVIEIFPEKDFFEFSIGGMRPFSKLADELLAIAAPAMKGIVNREVQPYNEEGREKLIFKAQYLQKWDEATAEINKYWQQLSIEDFNETFNLFGQYEFPIIQNILYFIDNEVHHRGQAYVYLRALGIEPPFFWER
>NZ_CP017774.1|WP_071184545.1|1798977_1800024_-|thiamine-phosphate-kinase
MIEDKNPQRTSIAQLGEFGLIDHLTKNFEINQASTLKGIGDDAAVLDFKDKKVVVSTDIMVEGVHFDLAYMPLKHLGYKAVVSNVSDICAMNAKATQITVSIAVSNRFPLEALEELFHGITLAANEYKVDVIGGDTTSSQKGLIISITVLGEADEEEIVYRNGAKPTNLLVVTGDIGAAYMGLQVLEREKQVFQVNPNSQPDLELYTYLIERQLKPEARKDVRTLLHALEIKPTSMIDISDGLSSEIIHLCKQSKVGCNLYEDKLPLDPQFINVCEEFDIDSTTVAINGGEDYELLFTIPIEDFDKIKGNPNFSIIGHMTEESEGIHLVTRANTKIPLKARGWNALSE
>NZ_CP017774.1|WP_071184555.1|1812672_1815435_+|PD-(D/E)XK-nuclease-family-protein
MINSTFLDKIAQVLIEKYSARLANTIVVLPNKRAKIFLIEALKKQVSNNILAPEIISIEDFIQDIAGARTVDPIELLFEFYEVYLSITDKSSQQSFELFANWAKTLLQDFNEIDRYLLDPTHVLSYLKDIEDIKKWGIEVENKTQLLEKYIDFWKLLPLYYQSLHAHLLQKGIGYQGLIYRESVENLNHFSNSITDKQFVFAGFNALNASEEKIIQHLISNDQAKIYWDADQIFLNDPYHDAGLFLRRFKESWKHYKTNPFEWIVDDFSQSKNIQIIGTPKSIGQAKISGSIIEKIIEENPTTSLDKVAIVLGEENLLVPLLYSLPSTVGALNITMGYSSKNNPAQILIAKLFKMHTNALSRNAKSYVFYYKDVLDILTHPLVEPYAKTTALVDIINKNNYTFISLHKLMELNANPTDLFLLLFQKWEEGSIAVLQTVSKLLLTIKGNLSNDNEEEKITKAFVFAIFKVINKLINYYSKHQHIDKIETLHAIYKQVIDLAEVSFEGEPLNGLQIMGVLESRVLDFDTVIVTSMNEGKFPAGKSQNSFIPYDVKRELGLPTFKEKDAIYTYHFYHLLQRAKNIYLLYNTESEGLDAGEKSRFITQLEVEKQQSHNLSHEIYNAVLPETAYSPMVIEKSPAVMERLKKIAEEGFSPSALTSYIRNPIQFYFQKILRIREVEEVEENIALNTLGTIIHETLKVLYEPFIGKFISESDIDNCFKLIDAEVLKQFKIVYKEGEIKKGRNLLAFEVAKRNVSNFLKMELESIKAGDAVKIIALEQRYERFLEHPDLPFRVKIGGEVDRIEERNGIIRIIDYKTGKVEKTSVSLKTWNGLTQELKNDKIIQVLAYAFMYEQQANGKQIEAGIISFKNLKSGFLPFQFKVDKDVQQIINQEIMTNYLEQIVLLLKEILDPEKSFEENI
>NZ_CP017774.1|WP_071184556.1|1815459_1816242_-|alpha/beta-hydrolase
MKQIQFKNTSISYTDSGKGTAIILLHGFLENQTMWDAFVPKFSKKYRIITIDLLGHGETDCMGYVHSMENNADVVHAVLAELRIRKAIFVGHSMGGYVALAFAEMYPDYIKGLVLLNSTSRADSDERKANRDRAIKAVKQSFINFISLSIANLFSEENRERLQDKIELVKKEALKTPLQGIVASLEGMKIRMDREVILHLTPYPKMLILGKKDPVLTYEENMEQIEETAVQLVTFPDGHMSHIENETELTKVLLDFFKKI
>NZ_CP017774.1|WP_071184557.1|1816491_1816848_+|hypothetical-protein
MNQVSDLTTNVLFETEKGYSYQCDVTNSVIINFADTVSTYKIQDFLIFQRKVNSVDILNMLYDLSDQSDAQLIETTKRNFSRKLTICEIVQLRELLNGTKFTLSLHSMLCDILTVNLV
>NZ_CP017774.1|WP_071184558.1|1816934_1817453_+|ferritin
MKDLLRTNTSLTEGIEQILNLQAKIESDASNKYLAMAAWLDRNGYANTAEYLYKQAEEEREHFLKVFKYITDMGGIAITPSVSEVQQEFASFREVFEIALQNEIAVTKAVNKVIAKCRAENDYATEDFMMWYVSEQREEEKNARRALELFELINENEATGKFALDVQIAKIG
>NZ_CP017774.1|WP_071184559.1|1817654_1818098_+|cyanase
MNREVCTAMVIEAKQQKQITYQYIAQAINRNIVWTTSAILGQNTFDANEAKIICEILDLDVNVEKALQIFPEKGVSAIMPPTDPLIYRLYEIVLVYGETIKEVIHEKAGDGIMSAIDFTMDIEKEENPKGDRIKIILDGKFLAYKKW
>NZ_CP017774.1|WP_071184560.1|1818410_1818872_+|hypothetical-protein
MNRLVIIGNGFDLAHGLPTSYRDFINDYWRGIKDSNHNDEFTSFTFNTKIEFENIKNIDCISKQFIALDENVKFSEAEIYHEYGNNILTGKYPRAHILNYKNDFFRLINQKAIENWVDIENEYYRELKKIVVSKPENSLVDNNEFEISKKKKY
>NZ_CP017774.1|WP_083382069.1|1818865_1819621_+|hypothetical-protein
MLRLNNEFEQVKNLLERYLKEKVEEQYDFTMHRNNPFIDLLLPEFINRFDEDRYLKEFKSGDHLYVREFLEKFGEKNHLITCFLSFNYTKVVEQYYNIFAFSKQINYIHGKLNTSVNKVNFGFGDEMDDDYKLIENIDDNEYLKNFKSFQYLQNSNYKSLLDFVESDKKFQVYIMGHSCGLSDRTMLNTIFEHSNCISIKVFYHQREDGSDNYTEIIQNISRHFNKKKLMREKIVNKTLCHPLPQIQLPKK
>NZ_CP017774.1|WP_071184561.1|1820023_1821316_-|M24-family-metallopeptidase
MKYHPIDRHLFIKNRSKFTAQMSPKSIAIFNSNDIYPVSADSTLPFAQHRDIFYLSGIDQEESILLLCPDAPYEHQKEMLFLKETSELIAIWEGAKLTKEEAFAVSGIKTVHWLQDFEKVLFEMMTYTDTMYINTNEHYRSHVETETREARFVKWWKEKYPAHAVAKSNPILQRLRSVKENEELDLIQHACNITEKGFRRVLSFVKPNVTEYEIEAEFIHEFIRNRSKGFAYTPIIASGNNANVLHYIENNKECKAGDLILLDVAAEYANYSSDLTRTIPISGRYSERQKAVYNAVLRVKNEATHMLTPGTLWKQYQAEVGKIMSSELLGLGLLDKADVQNENPEWPAYKKYFMHGTSHHMGLDTHDYGILTEPMQANMVFTVEPGIYIPEEGFGIRLEDNVVIQPTGEPFNLMKNIPIEIEEIENLMNS
>NZ_CP017774.1|WP_071184562.1|1821505_1822867_-|hydroxymethylglutaryl-CoA-synthase-family-protein
MKTGIDALSFDVAKLHLPIKTLAEARNIEPEKLEKGLGLLKMTLPDTHQDSVVFAANALTKLIQDNQIDLNEIARIYVGTESAIDNAKPIGSFLIDLMEQKFGENTLAECDVVDFTFACIGGVDAMQNCLDFIKLNPTKKAIVVTTDFAKYDLNSTGEYTQGAGATAMLITVNPRIIAFENHWATNTKGVFDFFKPHRTVSKEAITGNTNNESWFDNLEAEIEIHKDQPVFDGQYSNQCYMDRTRNAYFSFKKLKQTSATLYQSWNSIIMHLPYSFQGRRMLSEIYALDAENSIISGEETPAEYQNKLKETSKTPEYKNFVEEKLMPAELASSLIGNLYTGSIFMGFLSTLAHFYDTKKEISGNTFGFLAYGSGSKSKVFEGIIQDEWKAALANVNLFETLAESFEIDFDTYEKLHKKEQKQSIQSPKNEWILDRIEKEIPNLIGARYYKWID
>NZ_CP017774.1|WP_071184563.1|1823237_1823903_+|succinate-dehydrogenase-cytochrome-b-subunit
MAKSGLLKSSIAKKVAMALSGLFLMLFLAQHFLINLTSVISADVFNSISHFMGTNPLVQFVIQPILIVGVIFHFIMGFVLDIQNKKARPIGYASYNGAANASWASRNMIISGSVILAFLAVHFYDFWVPEMVYKYVEFNPADETRYFHELAEKFVSPVRTGLYSLSFVLLSLHLRHGFSSSFQSVGANNKYTKGMKGFGLWFSVIVPLGFVFIALFHHFNH

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Crispr_ID: NZ_CP017774_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017774_4

2524981-2525221

Orphan

Consensus_repeat	Method
TTATGAGCCCGACGAGCTGCCTACTGCTCTATCCCGCGATGTATTTTCAAT	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP017774_4

>merge|NZ_CP017774|4|2524981-2525221|PILER-CR
TTATGAGCCCGACGAGCTGCCTACTGCTCTATCCCGCGATGTATTTTCAATATATTTTTAGAACCTGTGTCCGCCTTGGCGGATATGAGCTCTTTGATTTGCCTACTGCTCTATCCCGCGATGTGCGTTTTGTAATCTCAATAAGGCTATCTTAGTAGCGGGAACAGGACTCGAACCTGTGACCTTCGGGTTATGAGCCCGACGAGCTGCCTACTGCTCTATCCCGCGATATATTTTCAAT

>NZ_CP017774|4|2|2524981-2525221|PILER-CR
TTATGAGCCCGACGAGCTGCCTACTGCTCTATCCCGCGATGTATTTTCAAT	ATATTTTTAGAACCTGTGTCCGCCTTGGCGGATATGAGCTCTTTGAT
TTGCCTACTGCTCTATCCCGCGATGTGCGTTTTGTAATCTCAATAAGGCTA	TCTTAGTAGCGGGAACAGGACTCGAACCTGTGACCTTCGGGTTATGAGCCCGACGAGCTGCCTACT
GCTCTATCCCGCGATATATTTTCAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017774.1\|WP_071185081.1\|2529849_2530674_-\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|234984
NZ_CP017774.1\|WP_071185077.1\|2526502_2527813_+\|ribosome-biogenesis-GTPase-Der	unknown	unknown	gnl\|CDD\|234628
NZ_CP017774.1\|WP_071186322.1\|2513271_2516109_-\|glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|379757
NZ_CP017774.1\|WP_083382103.1\|2520972_2522901_+\|sialate-O-acetylesterase	unknown	unknown	gnl\|CDD\|377084
NZ_CP017774.1\|WP_071185084.1\|2532559_2533306_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|238847
NZ_CP017774.1\|WP_071185072.1\|2512121_2513246_-\|endo-1,4-beta-xylanase	unknown	unknown	gnl\|CDD\|366032
NZ_CP017774.1\|WP_071185073.1\|2516183_2518349_-\|alpha-glucuronidase	unknown	unknown	gnl\|CDD\|226187
NZ_CP017774.1\|WP_071186327.1\|2527877_2528117_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017774.1\|WP_071185078.1\|2528359_2528863_-\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NZ_CP017774.1\|WP_071186323.1\|2518608_2520798_+\|glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|185053
NZ_CP017774.1\|WP_071185076.1\|2525411_2526293_+\|GTPase-Era	unknown	unknown	gnl\|CDD\|234624
NZ_CP017774.1\|WP_071185075.1\|2524632_2524887_-\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|198396
NZ_CP017774.1\|WP_071185080.1\|2529443_2529740_+\|glycoside-hydrolase	unknown	unknown	gnl\|CDD\|199892
NZ_CP017774.1\|WP_071185082.1\|2530725_2531346_-\|bifunctional-nuclease-family-protein	unknown	unknown	gnl\|CDD\|376830
NZ_CP017774.1\|WP_071185069.1\|2508541_2509396_-\|transketolase	unknown	unknown	gnl\|CDD\|238970
NZ_CP017774.1\|WP_071185071.1\|2510661_2512095_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225121
NZ_CP017774.1\|WP_071185079.1\|2528869_2529205_-\|2TM-domain-containing-protein	unknown	unknown	gnl\|CDD\|379083
NZ_CP017774.1\|WP_071185083.1\|2531483_2532452_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NZ_CP017774.1\|WP_071185070.1\|2509611_2510631_-\|glycoside-hydrolase-family-43-protein	unknown	unknown	gnl\|CDD\|350131
NZ_CP017774.1\|WP_071185074.1\|2522947_2523979_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525

Protein	Function_ID	Function_description	E-value
NZ_CP017774.1\|WP_071185081.1\|2529849_2530674_-\|thymidylate-synthase	gnl\|CDD\|234984	PRK01827, thyA, thymidylate synthase; Reviewed.	0
NZ_CP017774.1\|WP_071185077.1\|2526502_2527813_+\|ribosome-biogenesis-GTPase-Der	gnl\|CDD\|234628	PRK00093, PRK00093, GTP-binding protein Der; Reviewed.	0
NZ_CP017774.1\|WP_071186322.1\|2513271_2516109_-\|glycosyl-hydrolase	gnl\|CDD\|379757	pfam15979, Glyco_hydro_115, Glycosyl hydrolase family 115. Glyco_hydro_115 is a family of glycoside hydrolases likely to have the activity of xylan a-1,2-glucuronidase, EC:3.2.1.131, or a-(4-O-methyl)-glucuronidase EC:3.2.1.-.	0
NZ_CP017774.1\|WP_083382103.1\|2520972_2522901_+\|sialate-O-acetylesterase	gnl\|CDD\|377084	pfam03629, SASA, Carbohydrate esterase, sialic acid-specific acetylesterase. The catalytic triad of this esterase enzyme comprises residues Ser127, His403 and Asp391 in UniProtKB:P70665.	1.56243e-16
NZ_CP017774.1\|WP_071185084.1\|2532559_2533306_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	3.31643e-61
NZ_CP017774.1\|WP_071185072.1\|2512121_2513246_-\|endo-1,4-beta-xylanase	gnl\|CDD\|366032	pfam00331, Glyco_hydro_10, Glycosyl hydrolase family 10.	1.00405e-118
NZ_CP017774.1\|WP_071185073.1\|2516183_2518349_-\|alpha-glucuronidase	gnl\|CDD\|226187	COG3661, AguA, Alpha-glucuronidase [Carbohydrate transport and metabolism].	0
NZ_CP017774.1\|WP_071185079.1\|2528869_2529205_-\|2TM-domain-containing-protein	gnl\|CDD\|379083	pfam13239, 2TM, 2TM domain. This short region contains two transmembrane alpha helices that are found associated with a wide range of other domains. This domain may be involved in cell lysis or peptidoglycan turnover.	3.8945e-14
NZ_CP017774.1\|WP_071185078.1\|2528359_2528863_-\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	2.14854e-88
NZ_CP017774.1\|WP_071186323.1\|2518608_2520798_+\|glycosyl-hydrolase	gnl\|CDD\|185053	PRK15098, PRK15098, beta-glucosidase BglX.	1.91224e-145
NZ_CP017774.1\|WP_071185076.1\|2525411_2526293_+\|GTPase-Era	gnl\|CDD\|234624	PRK00089, era, GTPase Era; Reviewed.	4.95264e-153
NZ_CP017774.1\|WP_071185075.1\|2524632_2524887_-\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|198396	cd10449, GIY-YIG_SLX1_like, Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs. Structure-specific endonuclease subunit SLX1 is a highly conserved protein from yeast to human, with an N-terminal GIY-YIG endonuclease domain and a C-terminal PHD-type zinc finger postulated to mediate protein-protein or protein-DNA interaction. SLX1 forms active heterodimeric complexes with its SLX4 partner, which has additional roles in the DNA damage response that are distinct from the function of the heterodimeric SLX1-SLX4 nuclease. In yeast, the SLX1-SLX4 complex functions as a 5' flap endonuclease that maintains ribosomal DNA copy number, where SLX1 and SLX4 are shown to be catalytic and regulatory subunits, respectively. This endonuclease introduces single-strand cuts in duplex DNA on the 3' side of junctions with single-strand DNA. In addition to 5' flap endonuclease activity, human SLX1-SLX4 complex has been identified as a Holliday junction resolvase that promotes symmetrical cleavage of static and migrating Holliday junctions. SLX1 also associates with MUS81, EME1, C20orf94, PLK1, and ERCC1. Some eukaryotic SLX1 homologs lack the zinc finger domain, but possess intrinsically unstructured extensions of unknown function. These unstructured segments might be involved in interactions with other proteins.	3.64224e-21
NZ_CP017774.1\|WP_071185080.1\|2529443_2529740_+\|glycoside-hydrolase	gnl\|CDD\|199892	cd07184, E_set_Isoamylase_like_N, N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins. E or "early" set domains are associated with the catalytic domain of isoamylase-like proteins at the N-terminal end. Isoamylase is one of the starch-debranching enzymes that catalyze the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen. Isoamylase contains a bound calcium ion, but this is not in the same position as the conserved calcium ion that has been reported in other alpha-amylase family enzymes. The N-terminal domain of isoamylase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and the beta subunit of AMP-activated protein kinase.	1.97223e-29
NZ_CP017774.1\|WP_071185082.1\|2530725_2531346_-\|bifunctional-nuclease-family-protein	gnl\|CDD\|376830	pfam02577, DNase-RNase, Bifunctional nuclease. This family is a bifunctional nuclease, with both DNase and RNase activity. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site.	7.77746e-60
NZ_CP017774.1\|WP_071185069.1\|2508541_2509396_-\|transketolase	gnl\|CDD\|238970	cd02012, TPP_TK, Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.	1.25177e-111
NZ_CP017774.1\|WP_071185071.1\|2510661_2512095_-\|MFS-transporter	gnl\|CDD\|225121	COG2211, MelB, Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism].	7.93597e-112
NZ_CP017774.1\|WP_071185083.1\|2531483_2532452_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	1.1939e-81
NZ_CP017774.1\|WP_071185070.1\|2509611_2510631_-\|glycoside-hydrolase-family-43-protein	gnl\|CDD\|350131	cd18619, GH43_CoXyl43_like, Glycosyl hydrolase family 43 protein such as metagenomic beta-xylosidase/alpha-L-arabinofuranosidase CoXyl43. This glycosyl hydrolase family 43 (GH43) subgroup belongs to the GH43_AXH-like subgroup which includes enzymes that have been characterized with beta-xylosidase (EC 3.2.1.37), alpha-L-arabinofuranosidase (EC 3.2.1.55), alpha-1,2-L-arabinofuranosidase 43A (arabinan-specific; EC 3.2.1.-), endo-alpha-L-arabinanase as well as arabinoxylan arabinofuranohydrolase (AXH) activities. GH43 are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Many GH43 enzymes display both alpha-L-arabinofuranosidase and beta-D-xylosidase activity using aryl-glycosides as substrates. Included in this subfamily is the metagenomic beta-xylosidase/alpha-L-arabinofuranosidase CoXyl43, which shows synergy with Trichoderma reesei cellulases and promotes plant biomass saccharification by degrading xylo-oligosaccharides, such as xylobiose and xylotriose, into the monosaccharide xylose. Studies show that the hydrolytic activity of CoXyl43 is stimulated in the presence of calcium. Several of these enzymes also contain carbohydrate binding modules (CBMs) that bind cellulose or xylan. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	0
NZ_CP017774.1\|WP_071185074.1\|2522947_2523979_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	8.98442e-105

>NZ_CP017774.1|WP_071185075.1|2524632_2524887_-|GIY-YIG-nuclease-family-protein
MDEFVVYILFSENFNQHYTGYTSNVIDRFKSHNHLATKGHTIKYRPWIIIHIEFFNSKSEAMKREKYFKTGIGREFIKNIIKNL
>NZ_CP017774.1|WP_071185074.1|2522947_2523979_-|LacI-family-transcriptional-regulator
MEENKDITIYDIAEKLNLATSTISRALKDHPSISDKTIKKVKKTAEEMGYVPNTLAAGLRGNKTNTIGVLIPTVTQPFLSSLISGIEITAQKSGYNVIIMQSHDSYEEEVSLAKSLYSSRVSGVISSLAMETRDTSHFQQFVSNNIPLVFVDRVPKDFNTFRVIIDNYAAGYKATKHLIEQGCTRIAHLTAGSEFGNLYSERKRGYLDALKDHNLPLIEELIVNLKTVTYEEGAKASNKLFDLELRPDGIFASGDIIAVSAIQTAKKRGIKIPEELAIIGFNNDPISQIIDPNLSTITHPAAKMGKASAEIILKNIKSNKKDEVKEITFLNTEVLVRESSKRI
>NZ_CP017774.1|WP_083382103.1|2520972_2522901_+|sialate-O-acetylesterase
MNKLKNALIVLLFIPSNMILSQIKLPKLISDGVVLQRNEKVKIWGWASPKEKIKLEFKSKVYFTEADQEGNWNIILQAEKAGGPYQMALKASNEIVIKDILFGDVWICSGQSNMELPMERLKEKYGEVIKNAKNANIRHFLVPDKYNFQKEQADLDSGNWISASPETVLNFSGVAYFFAKNIYEKHQVPIGLINSALGGSPIEAWLSDTALTAFPEAYNEAQKFKSNDYIKEIETADKKRNEEWYQLLNANDEGVKNNWNLAGIDDGNWEQMSIPGFWNRQSIGNVNGAVWFRKEIQIPKSMVGKPAKLFMGCIVDQDFVYVNDELVGTTGYQYPPRRYTVKPTVLKEGKNVISIRVINNSGQGGFVLDKPYYLAVDKDTIDLKGLWKYKLGATMKPLRGETFIRWKPEGLFNAMIAPLTNLKIKGVLWYQGESNSGNPKLYAKALPALIQDWRTKWGQGNFPFLFVQLPNYMETFSEPRESNWAALRQAQLETLSVPNTAMAVTIDLGEWNDIHPLNKEDVGKRLSLLARKLAYGERKLQASSPMPNTSVFEKDKAIISFKNSGGGLIVKKGTELKSFAISDDGKNFVWAKAKIIGNNVEVWNEKISNPTIVRYAWDNNPEDANLFSKEGLPATPFEVKKK
>NZ_CP017774.1|WP_071186323.1|2518608_2520798_+|glycosyl-hydrolase
MLLMVLVALHCQSQTLPFYNTKLPIDQRVQDLISRLTLEEKVEQMMNATPEIKRLNIAPYDYWNEALHGVGRSGTATVFPQAIGLGATFDTDLALKVSTAISDEARAMYNVAKAKGYNKQYGGLTFWTPNINIFRDPRWGRGQETYGEDPFLTAMIGTEFVKGLQGDNPIYLKTAACAKHFAVHSGPEKVRHEFNAEVTPKDLWETYLPAFQALVEAKVESVMCAYNSTDGEPCCANKYLITDVLRKQWGFKGHVVTDCGAIDDFYVPKDKGGHGIVKTQSEAAALVLKSGVSLNCGDSYKSLPQAVKDGLITEKDIDKQLAILLQTRFKLGLFDPMGSNPYDAIAPEVVNSKAHRELAREVAQKSMVLLKNNGILPLKNDLSKYFVTGPNAASIEVLLGNYYGINPNMVTILEGITASISPASQLQYRLGAMLNKESINPINYATGNAGDSDVTIVVLGVSSTIEGEEGDSLDSSTAGDRLDYNLSQNQIDYLKELRKTADKNPNDKNPIVTVITGGSPMNLAEVQELSDAVLLAWYPGEEGGTAVADILFGRTAPSGKLPITFPKSLDQLPPFEDYSMKGRTYRYMNEDPMYPFGFGLSYTTFSYGDIKVFSDKISRKDNLRIFVKVTNTGKVKADEVVQLYISDLVASVDVPNFQLANMKRITLEPGEVKEVEFTLTPEAFEMVNNKGNRVMEAGDFKIYVGGSSPMKRSFELGAPKMSEVIINVK
>NZ_CP017774.1|WP_071185073.1|2516183_2518349_-|alpha-glucuronidase
MNQPLFLYILLQLSFLIAPFNMSAQEDYKLWLQYKKVQDTKIATNYHSKINGIVALGNSETIQTAIKEIQLGLSGLIGHQITLQKNTNTENMLILGNQSSLDEAVLKNVKSEFDLINNEGYIIKTIQLKNKKHILITAKTDIGVLYGVFNFLKLLQTNQQIENLAITDSPRINIRMLNHWDNLDRTVERGYAGFSLWNWQKLPDFIDQRYIDYARANASIGINGTVINNVNANALILTPQYLEKVEALAKVFRPYGIKVYLTARFSAPIEIGGLKTADPFDAAVKNWWKEKAAEIYARIPDFGGFLVKANSEGQPGPQNYGRNHVDGANMLADAVAPFGGIVMWRAFVYSEHDVNDRAKQAYSEFVPYDGQFRNNVIVQVKNGAIDFQPREPFHPMFGAMPKTPLMMEFQITQEYLGFSTHLVYLPKLYQEVLESDTYSKGKGSTVAKIIDGTVDNHKISGIAGVANIGNDINWTGHPFAQANWYGFGRLAWNPYQDSETIAEDWLRMTFSNDEKFIKPVKEMMLESREAVVNYMTPLGLHHIMDTGHHYGPGPWVSNLSRPDWNPTYYHKADTKGIGFDRSKTGSNATAQYSPEVAKIFDDVANCPEKDLLWFHHISWDYKLKNGETLWNSLALKYQEGVNQVESMNTTWNKMEQYVDQVRFKEVQMLLNIQHKEAKWWRDACLLYFQQYSGKELPKSVEKPTQTLNYFKSLKFPFAPGN
>NZ_CP017774.1|WP_071186322.1|2513271_2516109_-|glycosyl-hydrolase
MNIGYAINPNKYVTNKASKESFPLASNGKVASLLVSDVDFPGVLRVVNHLQNDIRLVTSISPNIINKSSTENYVVIIGTLGKSPIIDQLAREGKIDTSQLQGKWEKFTTQVVNNPIAGVQKALVIAGSDKRGTIYGIYDLSNQIGVSPWGFWADVPSKKQSELHVLPGVHTLGEPKVKYRGIFINDEAPALTGWVRQNYGKFNAKFYDKVFELILRMKGNYLWPAMWGEKFYADDPQNGILADEYGIVMGTSHHEPLAKAHQEWNKSVNGVWDFNKNPEGLKKFWTAGMERMGNKETLVTIGMRGDGDEPMTEGTAIDLLENIVKTQREIITNVTKKPAEETPQIWALYKEVQEYYDKGMKVPDDVTLLLCDDNWGNLRKLTALDAKPRKGGYGIYYHFDYVGGPRSYKWINSNQIERTWEQMHLAYEHGVDKVWIVNVGDIKPMEFPIEFFLDYAWNPEYWNETNLNDYYLQWSKDNFGGQNTEEIANLLKMYSKYNANRKPELLDPSSYSLIHYNEAENVVSDYNKLAQKAQEINAQLKPEYKDAFYQLILYPVLASANLNELYVTTAKNNLYASQGRAATNEYAEKVKTLFDKDAELSSYYHKTMANGKWNHMMSQTHIGYKNWQDPKTNIIPNTKTIEVPVKAELGVAIEGSTNWWPNATEKAVLPSFNSSENSTSYIDIFNRGTTPFDFKITSKSNWIKFSKTKGNIGKQERIFVEIDWKKAPQGSQTAAAVISGAGKEIPINIKINNTKTDNAKGFVENNGYIVIKAVNFSNKYEPESFKWKIVPNLGKTDGAVISSPIKKGRVELNENSPKLSYNVHLKNTGIVKVQMHFSPTINYSTREGMYYGLSFDNESPTKVNYASDPIIFDYNGKVTKNWDKNVTNNIKIITTEFKIDKAGNHTLNYYRMDEGLVLQKIIIETEKSELKPTLLCPSESSNIKN
>NZ_CP017774.1|WP_071185072.1|2512121_2513246_-|endo-1,4-beta-xylanase
MKPTKSFLFFFSAILALSSCNNKINSQSAAKNSLKNAYKGDFYIGTALDINQIEEKNPKVTNLISKEFNSITPENIMKSMFLQPEENKFDFDVSDKYVAFGQKHKMFIHGHTLVWHSQLAPWMSKIKDSASMAKMLTNHITTVVKKYKGKIDSWDVVNEALNEDGSLRKSVFLKTYGKDFITHAFKTAAEIDSKVELYYNDYNLCNAKKRQGAVELVKNLQKNGVKIDGVGEQGHWHLDTPTLEEIEQTILDFSTLGVKVSFSELDISVLPSPYGLQGAEISQRFENNEKMNPYPKSLPDSMQVKLAQRYNDIFKLFLKHKDKISRVTFWGVNDTQSWLNDFPIKGRTDYPLLFDTNLQPKKAYESVISLKAKK
>NZ_CP017774.1|WP_071185071.1|2510661_2512095_-|MFS-transporter
MTSISQKLSIKEKIGYSLGDLAANLVFQTLMTYLAYFYTDIYGLSPSDSSIIMLSVGLVAAFIFNPIIGAIADRTNSKWGKFRPWILWTAVPLGVIALLAFTTPDFSYKGKVIYAVITYTLLLLFYAGNNLPYSALSGVITGDMGDRNSLSSYRFVAVMFAQFFVQVFMLGIIKSAGNGDKAIGIEKVMTVLAIVGTIMLLITFFTTKERIIPKPEQKSSVGEDLADLVKNKPWLIMLSLTTLVFITLAMKGGAYVYYFENYVDKQELAIVIQPILDVLNSIGLNQFGEDPISAGFGLFNAGGIIFMIVGITLSKRLADKYGKRDIFGFFLFISTLFIIAFYFFSPQSVSLMFISQIFHGFFYGITIPLLWAMIADVADYSEWKNNRRATAIIFSAMMVGLKAGLSIGGALTTSLLGYFNYTPNSLEQSATAINGIKLLVSVFPAIPFMIGVGLLFFYEINKKMEVQIESDLKGRRA
>NZ_CP017774.1|WP_071185070.1|2509611_2510631_-|glycoside-hydrolase-family-43-protein
MPEESIKHIDFNELAKTAISQPLVSNIYTADPSAHVFNGKIYIYPSHDIDAGIPFNDNGDHFGMEDYHVISMESVTSEAVDNGLALHVDDVPWAERQMWAPDAAHKNGKYYLYFPAKRANGIFQIGVAISDSPIGPFLPEPEAINRSYSIDPAVFEDEDGKYYMYFGGIWGGQLQKYRNNKYAEENEEPSADEAALGPIVALLTDDMKEFAEEPKEIKILDENGEEILAGDNERRFFEASWVHKYNGKYYFSYSTGDTHFICYATGDNPYGPFTYQGIILKPVIGWTSHHSICEVEGKWYLFYHDSSLSKGVTHLRSIKVTEITYNEDDTIIPINPYLE
>NZ_CP017774.1|WP_071185069.1|2508541_2509396_-|transketolase
MKPNTQQLNDLIIQVRRDILRMVHAVNSGHPGGSLGCTEFLVALYQNIMDRKEGWDMDGIGEDLFFLSNGHISPVFYSVLARSGYFPVSELATFRLLNSRLQGHPTTHDNLPGVRIASGSLGQGLSVAIGAAQAKKLNNDKHIIYTLHGDGELQEGQNWEAIMYASAKGVDNLIATVDLNGKQIDGTTDEVLAMGSLRAKFEAFDWEVVEITKGNDVEAIIGGMAEAKARTGKGKPVCVLLHTEMGNGVDYMMYSHAWHGKAPNDAQLENALGQNYNTGGNSDY
>NZ_CP017774.1|WP_071185076.1|2525411_2526293_+|GTPase-Era
MTHKAGFVNIIGNPNVGKSTLMNAFVGERLSIITSKAQTTRHRILGIVNGDDFQMVLSDTPGIIKPAYEMQESMMDFVKSAFEDADVLIYMVEIGEQELKDEAFFNKIIHSKIPVLLLLNKIDNSNQEQLEQQVAFWTEKVPNAEIYPISALQNFNVPEVFQRIISLLPDSPPYYPKDQLTDKPERFFVNEIIREKILLNYSKEIPYAVEIVTEEFVETDTIIRIRSLIMVERDTQKGIVIGHKGAALKKVGMDARVDLEKFFGKQIHIELYVKVNKNWRSNANMLKRFGYNQ
>NZ_CP017774.1|WP_071185077.1|2526502_2527813_+|ribosome-biogenesis-GTPase-Der
MNNIVAIVGRPNVGKSTLFNRLIQRREAIVDSVSGVTRDRNYGKSEWNGKEFSVIDTGGYVRGSDDVFEGEIRKQVELAIDEADVIIFVVDVEEGITPMDETVAKLLRKVTKPVLLAVNKVDNAMREKDAVEFYNLGLGDYYTFASISGSGTGDLLDALIDAFPEKPEPVQEEVILPRFAVVGRPNAGKSSFINALIGKDRFMVTDIAGTTRDAIDTKFDRFGFEFNLVDTAGIRRKAKVKEDLEFYSVMRSVRAIEHADICILVIDATRGFEGQDQSIFWLAEKNRKGVVILVNKWDLVEKDTMSTRDYEEKIKKELMPFTDVPILFVSALTKQRLLKALEATVKVYENRQQRIPTSKFNEFMLKVIEAYPPPATKGKYVKIKYCMQLPSPTPQFVFFANLPQYVKEPYKRYLENKIRENWDFSGVPIDIYIREK
>NZ_CP017774.1|WP_071186327.1|2527877_2528117_-|hypothetical-protein
MKNFAIKLVWFTTAYVFVFAGLNQTNVDLRIIMTLHLIGVILIPYMTYCVLTDKYKTNKTFKDWYEDYPMDTLEDEEDN
>NZ_CP017774.1|WP_071185078.1|2528359_2528863_-|dihydrofolate-reductase
MITMIAAAAQNKALGKDNQLIWHLPNDFKRFKSLTTGHHIIMGRKTFESFPKPLPNRTHIIITRQTNYKAEGCIIVDSIEKAIEKCPEGEESFIIGGGEIYQLAMPFSDKIELTVVHHNFEADAFFPEIKLEDWELINSDFQPKDEKHLYDYSFDTYIRKQKIPSEK
>NZ_CP017774.1|WP_071185079.1|2528869_2529205_-|2TM-domain-containing-protein
MKTEQYELYEYARKRITQKKRVYFHFVVLFLASLFLFVSTEVFHFNEDANWHIWLITVWLFLFILHFIKVFITDRFMSKNWEKEQIDRLIALQEKKIAELNDQINEESSTK
>NZ_CP017774.1|WP_071185080.1|2529443_2529740_+|glycoside-hydrolase
MPIKKQFVKSKPVCKVTFSIEAKEATQVSVIGDFNNWNPEEGALSKLKNGTFKGAFDLNKDAAYEFKYLVDGEYINETEADSFKWNEFAGTENSVLEV
>NZ_CP017774.1|WP_071185081.1|2529849_2530674_-|thymidylate-synthase
MKQYLDLVKHVMENGCQKGDRTGTGTKSVFGYQMRFDLSEGFPMVTTKKLHLKSIIYELLWFLKGETNIGYLKEHNVKIWDAWADQNGDLGPVYGHQWRNWNSEEIDQISDLIQELKTNPNSRRMLVSAWNPSVLPDTTKSFEENVANNKAALPPCHAFFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVCDLEPGEFIHTFGDAHIYNNHFEQLELQLSREPKPLPKMILNPEIKNIFDFDYSDFTLVGYEPHETIKGSVAV
>NZ_CP017774.1|WP_071185082.1|2530725_2531346_-|bifunctional-nuclease-family-protein
MSLVKLSIKGISYSQTQNGAYALILNEVDGERKLPIVIGAFEAQSIAIALEKEIKPPRPLTHDLFKNFAERFDIVVKQVIIHKLVDGVFYSSIICERDKIEEIIDARTSDAIALALRFNAPIFTYKNILDKAGIYLKTNPTDSDKENQPMDDVISNPESFTAEAESGRAYIKYSLQELNDLLIQAVEQEDYEKAAKIRDEISKRES
>NZ_CP017774.1|WP_071185083.1|2531483_2532452_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MSILIYAESAEGKFKKVAFEIASYAKKVAESLGTTVTALTINTENVAELAKYGVDKVLKVNNDKLAGFNAKAYADVIKQAAQQENTKLVILSSSTDSIYLSSLVAVNLEAGFASNVVGLPVSTAPFQVKRNAFSNKAFNITEINTEVKVIGLAKNSYGIFENASTLTEEAFNPSIGDNDFGIKVASIEKSSGKVSIADADIVVSGGRGLKGPENWNLIEDLAAVLGAATACSKPVSDLGWRPHAEHVGQTGKPVATNLYIAVGISGAIQHIAGINASKVKVVINTDAEAPFFKVADYGIVGDAFDVVPRLIEKLKAFKAQNA
>NZ_CP017774.1|WP_071185084.1|2532559_2533306_-|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MKILVCISHVPDTTSKINFTNADTEFDTNGVQYVINPNDEFGLTRAIWFQEQQGATVTVVNVGGPETEPTLRKALAIGANEAIRINATPTDGFFVAKQLAEVIKSGAYDLVIAGKESLDYNGGMVPGMIAGILGYNFLNACIDIAVDGTNVKAVREIDGGKETVTTSLPLIIGGQKGIVEEKDLRIPNMRGIMTARTKTLNVVEPVDAAINTKAVKFEKPAPKSAIKMVSPDNLDELIDLLHNEAKVI

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

797209 : 806279

Catovirus(14.29%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_071183814.1\|797209_798139_-	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	6.8e-09	34.4
WP_071183815.1\|798135_799059_-	glycosyltransferase	NA	NA	NA	NA
WP_071183816.1\|799110_799902_-	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	6.6e-05	29.8
WP_071183817.1\|799908_801000_-	GDP-mannose 4,6-dehydratase	M4QRT5	Synechococcus_phage	7.0e-122	62.9
WP_071183818.1\|801005_801926_-	GDP-L-fucose synthase	M1HWW2	Paramecium_bursaria_Chlorella_virus	3.1e-107	63.1
WP_071183819.1\|802039_803839_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.1e-23	24.2
WP_071183820.1\|804021_805149_-	acyltransferase	C6ZR20	Salmonella_phage	4.2e-05	29.1
WP_071183821.1\|805271_806279_-	mannose-1-phosphate guanylyltransferase	A0A1V0SH58	Hokovirus	1.1e-31	32.4

DBSCAN-SWA_2

1338054 : 1345999

Catovirus(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_071184187.1\|1338054_1339596_-\|tRNA	glycine--tRNA ligase	A0A1V0SAN4	Catovirus	2.8e-28	25.2
WP_071184188.1\|1339691_1340375_+	ComF family protein	NA	NA	NA	NA
WP_071184189.1\|1340495_1341104_+	superoxide dismutase	Q56AR7	Bacillus_thuringiensis_phage	1.1e-60	56.7
WP_071184190.1\|1341451_1343350_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.0e-15	24.7
WP_071184191.1\|1343535_1344459_-	sugar kinase	NA	NA	NA	NA
WP_071184192.1\|1344535_1345015_-	ribonuclease HI	J9Q745	Salmonella_phage	2.9e-24	40.8
WP_071184193.1\|1345017_1345587_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	8.9e-20	34.6
WP_007137004.1\|1345762_1345999_+	acyl carrier protein	B2ZXV3	Ralstonia_phage	1.8e-06	38.1

DBSCAN-SWA_3

3762465 : 3795004

Tupanvirus(14.29%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_071185987.1\|3762465_3763410_+\|tRNA	tRNA-dihydrouridine synthase family protein	NA	NA	NA	NA
WP_071185988.1\|3763501_3766741_-	cytochrome C biogenesis protein	NA	NA	NA	NA
WP_071185989.1\|3767113_3768160_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_071185990.1\|3768252_3768999_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_157499588.1\|3769035_3769551_-	hypothetical protein	NA	NA	NA	NA
WP_071185992.1\|3769589_3770156_-	acetyltransferase	NA	NA	NA	NA
WP_071185993.1\|3770246_3771074_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_071185994.1\|3771287_3771560_-	hypothetical protein	NA	NA	NA	NA
WP_140487980.1\|3771833_3773123_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_071185995.1\|3773268_3773772_-	DUF4304 domain-containing protein	NA	NA	NA	NA
WP_071185996.1\|3774024_3776940_-	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_071185997.1\|3777350_3778913_+	family 10 glycosylhydrolase	NA	NA	NA	NA
WP_071185998.1\|3778899_3780174_+	MFS transporter	NA	NA	NA	NA
WP_071185999.1\|3780305_3781901_+	glycoside hydrolase family 3 protein	NA	NA	NA	NA
WP_071186000.1\|3782035_3782674_+	peroxiredoxin	NA	NA	NA	NA
WP_071186001.1\|3782823_3783132_+	thioredoxin family protein	A0A2K9L3H4	Tupanvirus	1.5e-05	34.4
WP_071186002.1\|3783180_3783438_+	hypothetical protein	NA	NA	NA	NA
WP_071186003.1\|3783618_3784116_+	thiol peroxidase	NA	NA	NA	NA
WP_071186004.1\|3784117_3784492_+	diacylglycerol kinase family protein	NA	NA	NA	NA
WP_071186005.1\|3784512_3786957_+	DNA translocase FtsK	A0A218M9A2	Mycobacterium_phage	6.9e-69	42.3
WP_071186006.1\|3786962_3787604_+	outer membrane lipoprotein carrier protein LolA	NA	NA	NA	NA
WP_071186007.1\|3787612_3789082_+	YjgP/YjgQ family permease	NA	NA	NA	NA
WP_071186008.1\|3789083_3790217_+	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	9.6e-66	39.8
WP_157499564.1\|3790749_3791145_+	hypothetical protein	NA	NA	NA	NA
WP_083382152.1\|3791096_3791678_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	2.2e-26	36.8
WP_083382153.1\|3791702_3791927_+\|transposase	transposase	U5P429	Shigella_phage	6.6e-11	51.5
WP_071186009.1\|3792046_3792877_+\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_071185457.1\|3793027_3794230_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	6.9e-46	45.5
WP_071186010.1\|3794566_3795004_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	7.8e-16	37.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP017774

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection