CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP013246	Clostridium botulinum strain CDC_69094, complete genome	4 crisprs	RT,cas3,DEDDh,cas5,cas7,cas8b1,cas6,WYL,csa3,DinG	0	6	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP013246_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013246_1

402588-403077

Orphan

III-B

Consensus_repeat	Method
ATTTAAATACATCTCATGTTATTGTTCAAC	CRISPRCasFinder
ATTTAAATACATCTTATGTTAATGTTCAAC	CRT

7 spacers

The CRISPR arrays of NZ_CP013246_1

>merge|NZ_CP013246|1|402588-403077|CRISPRCasFinder,CRT
TTAATAATACATCATATGTTAATGTTCAACATGAATGGGTTGTTTGTTCAAGTTGGAAACTTCTCATTTAAATACATCTCATGTTATTGTTCAACTTTAAAAATGTCAATAGATCTTATGGGAGATGAATAATTTAAATACATCTCATGTTAATGTTCAACGATGGTAGCAAAAAATTATATATTCCAATTTGGATATTTAAATACATCTTATGTTAATGTTCAACCCAACTGTAGAACGTAGAGAGCATAACGTTTTTACATTTAAATACATCCTATGTTAATGTTCAACAGTTTCAAAGTAGAAAAAATGTATGGAACAGAAAAATTTAAATACATCTTATGTTAATGTTCAACTTAATACAATCGCTAGTAAATACGAATCAATAAGCTAATTTAAATACATCTTATGTTAATGTTCAACGGGACAACGAATTTACTAGAAGGTACAGACTACCCAAATTTAAATACATCTTATGTTAATGTTCAAC

>NZ_CP013246|1|1|402588-403077|CRISPRCasFinder
TTAATAATACATCATATGTTAATGTTCAAC	ATGAATGGGTTGTTTGTTCAAGTTGGAAACTTCTC
ATTTAAATACATCTCATGTTATTGTTCAAC	TTTAAAAATGTCAATAGATCTTATGGGAGATGAATA
ATTTAAATACATCTCATGTTAATGTTCAAC	GATGGTAGCAAAAAATTATATATTCCAATTTGGAT
ATTTAAATACATCTTATGTTAATGTTCAAC	CCAACTGTAGAACGTAGAGAGCATAACGTTTTTAC
ATTTAAATACATCCTATGTTAATGTTCAAC	AGTTTCAAAGTAGAAAAAATGTATGGAACAGAAAA
ATTTAAATACATCTTATGTTAATGTTCAAC	TTAATACAATCGCTAGTAAATACGAATCAATAAGCTA
ATTTAAATACATCTTATGTTAATGTTCAAC	GGGACAACGAATTTACTAGAAGGTACAGACTACCCAA
ATTTAAATACATCTTATGTTAATGTTCAAC

>NZ_CP013246|1|1|402588-403077|CRT
TTAATAATACATCATATGTTAATGTTCAAC	ATGAATGGGTTGTTTGTTCAAGTTGGAAACTTCTC
ATTTAAATACATCTCATGTTATTGTTCAAC	TTTAAAAATGTCAATAGATCTTATGGGAGATGAATA
ATTTAAATACATCTCATGTTAATGTTCAAC	GATGGTAGCAAAAAATTATATATTCCAATTTGGAT
ATTTAAATACATCTTATGTTAATGTTCAAC	CCAACTGTAGAACGTAGAGAGCATAACGTTTTTAC
ATTTAAATACATCCTATGTTAATGTTCAAC	AGTTTCAAAGTAGAAAAAATGTATGGAACAGAAAA
ATTTAAATACATCTTATGTTAATGTTCAAC	TTAATACAATCGCTAGTAAATACGAATCAATAAGCTA
ATTTAAATACATCTTATGTTAATGTTCAAC	GGGACAACGAATTTACTAGAAGGTACAGACTACCCAA
ATTTAAATACATCTTATGTTAATGTTCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013246.1\|WP_021106501.1\|405690_405915_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371241
NZ_CP013246.1\|WP_071647221.1\|401957_402146_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013246.1\|WP_061311363.1\|403387_404446_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013246.1\|WP_071647223.1\|405505_405679_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013246.1\|WP_075143902.1\|408727_408895_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013246.1\|WP_003358830.1\|408333_408585_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013246.1\|WP_003358866.1\|412713_413610_-\|homoserine-O-succinyltransferase	unknown	unknown	gnl\|CDD\|335664
NZ_CP013246.1\|WP_003358896.1\|409814_410636_-\|sporulation-transcription-factor-Spo0A	unknown	unknown	gnl\|CDD\|131922
NZ_CP013246.1\|WP_003394958.1\|406082_407279_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NZ_CP013246.1\|WP_071647220.1\|401713_401956_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013246.1\|WP_061292552.1\|392861_393746_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235853
NZ_CP013246.1\|WP_003359028.1\|396463_397936_-\|chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NZ_CP013246.1\|WP_003358985.1\|411065_412292_-\|SpoIVB-peptidase	unknown	unknown	gnl\|CDD\|274325
NZ_CP013246.1\|WP_012047589.1\|392668_392785_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013246.1\|WP_071647219.1\|401408_401576_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|235203
NZ_CP013246.1\|WP_003358835.1\|399968_400523_-\|hemerythrin	unknown	unknown	gnl\|CDD\|226454
NZ_CP013246.1\|WP_003358920.1\|395035_396376_-\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NZ_CP013246.1\|WP_003358988.1\|398361_399531_-\|alanine-racemase	unknown	unknown	gnl\|CDD\|143481
NZ_CP013246.1\|WP_071647222.1\|404694_405465_-\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|119407
NZ_CP013246.1\|WP_003358827.1\|393962_394796_-\|DUF975-family-protein	unknown	unknown	gnl\|CDD\|283754

Protein	Function_ID	Function_description	E-value
NZ_CP013246.1\|WP_021106501.1\|405690_405915_-\|hypothetical-protein	gnl\|CDD\|371241	pfam10779, XhlA, Haemolysin XhlA. XhlA is a cell-surface associated haemolysin that lyses the two most prevalent types of insect immune cells (granulocytes and plasmatocytes) as well as rabbit and horse erythrocytes. This family has had DUF1267, pfam06895, merged into it.	2.2723e-13
NZ_CP013246.1\|WP_003358827.1\|393962_394796_-\|DUF975-family-protein	gnl\|CDD\|283754	pfam06161, DUF975, Protein of unknown function (DUF975). Family of uncharacterized bacterial proteins.	6.54873e-34
NZ_CP013246.1\|WP_003358866.1\|412713_413610_-\|homoserine-O-succinyltransferase	gnl\|CDD\|335664	pfam04204, HTS, Homoserine O-succinyltransferase.	1.5941e-150
NZ_CP013246.1\|WP_003358896.1\|409814_410636_-\|sporulation-transcription-factor-Spo0A	gnl\|CDD\|131922	TIGR02875, stage_0_sporulation_protein_A, sporulation transcription factor Spo0A. Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination].	1.10279e-149
NZ_CP013246.1\|WP_003394958.1\|406082_407279_-\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	1.05856e-42
NZ_CP013246.1\|WP_003359028.1\|396463_397936_-\|chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	3.16152e-30
NZ_CP013246.1\|WP_003358985.1\|411065_412292_-\|SpoIVB-peptidase	gnl\|CDD\|274325	TIGR02860, stage_IV_sporulation_protein_B, stage IV sporulation protein B. SpoIVB, the stage IV sporulation protein B of endospore-forming bacteria such as Bacillus subtilis, is a serine proteinase, expressed in the spore (rather than mother cell) compartment, that participates in a proteolytic activation cascade for Sigma-K. It appears to be universal among endospore-forming bacteria and occurs nowhere else. [Cellular processes, Sporulation and germination].	1.63726e-173
NZ_CP013246.1\|WP_003358920.1\|395035_396376_-\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	1.09486e-118
NZ_CP013246.1\|WP_071647219.1\|401408_401576_-\|transcriptional-regulator	gnl\|CDD\|235203	PRK04024, PRK04024, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase.	0.00314091
NZ_CP013246.1\|WP_003358835.1\|399968_400523_-\|hemerythrin	gnl\|CDD\|226454	COG3945, COG3945, Uncharacterized conserved protein [Function unknown].	1.3393e-46
NZ_CP013246.1\|WP_061292552.1\|392861_393746_+\|SDR-family-oxidoreductase	gnl\|CDD\|235853	PRK06701, PRK06701, short chain dehydrogenase; Provisional.	1.37128e-165
NZ_CP013246.1\|WP_003358988.1\|398361_399531_-\|alanine-racemase	gnl\|CDD\|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	0
NZ_CP013246.1\|WP_071647222.1\|404694_405465_-\|SH3-domain-containing-protein	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	3.85934e-36

>NZ_CP013246.1|WP_071647221.1|401957_402146_-|hypothetical-protein
MNNKDRQKVADKKWIEKNREHATYLRNRSSARSFIRNKATTEDLEELKELIKEREEFLKREI
>NZ_CP013246.1|WP_071647220.1|401713_401956_-|hypothetical-protein
MRKARLLIIGLLIGACTRFIGIARAVEPAEDNCPENGEYMYCLDKTTPLWISIYDVHQEEKFIYLRQPNSNKIIKLVELK
>NZ_CP013246.1|WP_071647219.1|401408_401576_-|transcriptional-regulator
MSSFYRAKEVAEILDVSTTKAYRIIKQLNKELEEMGYITIAGRVPIKYFKEKYYC
>NZ_CP013246.1|WP_003358835.1|399968_400523_-|hemerythrin
MNSIELMVNEHKNIKRMLVVIRKYCFKVLKNEQVDYNDFYKIIDFVRNYADKHHHGKEEDYLFNRMIEEIKGPTEKLVKQGMLVEHDLGRLYMQNLEKALKALENGEEEAKIDIIANAVSYTDLLYRHIEKEDDVVYKFAERNLSKETLKKLDEDCERIEKEAREKGIQDKYKNLIHELEEKVK
>NZ_CP013246.1|WP_003358988.1|398361_399531_-|alanine-racemase
MFRNHRPVWEEVNLDNLSYNMRNIKKKVNCKEIFAVVKANGYGHGALDIASTLLENGATRLSVACLSEATELREGGITCPINILGITPPTLFEDIIDYNIEPVVFSYDCANQLSKAASLKNRIVKTHIAVDTGMGRLGFDPTVESLEEIKRIQDLSNIKIEGLCSHFSSSDEKDKSYSEYQFKIFQNFRKKLIEMNMKIPIYHMSNSAAIIDLPSTYLDGVRAGIILYGYYPSMEVNKENLHIKQVMTLKANIVHIKTIDSGKYVGYNRKFKTKRKSKIAILPLGYGDGYTRFLSNRGKVIINGQYAPIVGNICMDQCMIDVTDIKEVKVGDEVIIIGKDNINNLRYDAEDIASKVGMTSGEIMSIISKRVPRVYIKNGNIVKVRNYIA
>NZ_CP013246.1|WP_003359028.1|396463_397936_-|chemotaxis-protein
MRIFKDNAIEKEIIKISQDFQNQNVHALDEIEGSASKNRMVRFTAGIAKIVQVISPKVKKLINGVLLITTRISTFSVNLDYSGEHLKKSADKLYNSSGVLNSSIKEVKEAMQQITLAIEEDVETVEHISSGNIELIKYMDENKKNLGLVKNVNKELEFKAQSMEKDMTELNSILENMKTIVTGMSEIASKTNLLALNASIEAARAGEAGKGFAVVAEEVRKLSESTSKQLEKMEEFVNNIGTCSTNSSKSVKDTIGSIGELGEYTQAISSSSSKVREAIDIEVKSIELLAASMQEINASSEEINSNMDIIGENVQEVSKEAAVLSEKSLEIKYLADEMDKIDDEVSNLAKLSGDITGENYFKITNKDFIVAIDNAIKAHENWVQQLQNMAMENKIKPIQTDGQKCGFGHFYNSVMPRNEKIKEIWIKIDDIHKELHRVGGIVKSNIKDGHTEKAKENSKKATQLSQTIISMLSHIKSIAIETDKEGNLVL
>NZ_CP013246.1|WP_003358920.1|395035_396376_-|NCS2-family-permease
MGGRGIKEKDEGEVENKFNSLFNIKKYNTTVKGEILAGFTSFFAIVYIIAVNASILSDAGLPLEGAIIATVLSSFVGCILVGVISNAPLILVPGMGVNALFSYTIVGSMGLSWQQALAAVFVSGVVFSIVVFTRFSKTLIESIPTSLKEAITVGIGVLITFIGLQKSGIVIGSTTTFVALGHFNNPLVYVTFINLIITLILFIKNVPGNFLISMIVGTIISYFFGLIDMAKLTFSNFSLGAYKEVFFKMDFSSATSITFWIAVFSLTLVLVFENLGLLHAHINVMLKEENKFKTSFKACSLSAITCGFFGTSPTVATIETAAGITAGGKTGLTSIFTGILFLLSLFLLPIIKIIPNSAISPILIVIGGLMIKNILSINFNDFSEGFPAFLIIVMIPLTFSIVDGMAFGFICYPIVKLAGKKSKEISYAMYIISLMFLLNFILHAVS
>NZ_CP013246.1|WP_003358827.1|393962_394796_-|DUF975-family-protein
MEEKTILSNSQIKSKAKEALKGNWGTAVIAFIIFNIVMYSVNYVYNINQISNYIHDPYLVRENAGFGASGILFFIKLLLAGPMTYGITKFSMNLVRDKSHKIENIFEGFKHFSGTFIMNIVLGIYSFLWSLLLFIPFFAIVFVMVIREFSKTNMNFYSTGNDFSGWMIAIFILLIIVLTVALSMILFRYAMTYYIYIDNPDMGAMEAIKESVSMMKGNKTRLLLLYLSFILWYLLGIVTVGIAFLWITPYIKSTEAVFYDELKKSNEHNAHEAISAL
>NZ_CP013246.1|WP_061292552.1|392861_393746_+|SDR-family-oxidoreductase
MNEDLNFINSFPKSVPGQEQSKQPGIEAIMNPKPIFDNPNYKASAKLMDRVALITGGDSGIGRAVAVTFAKEGADISIVYFDEHEDAKETQAIIEGLGRKCLLIPGDITDDNFCNNAINQTINTFNKLDILVNNAAVQYVQSSIEDITKEQLEKTFKTNIFSMFYLVKAALPYLNRGASIINTASITAYKGQKLLIDYSSSKGAIVSFTRSLALSLWSKGIRVNAVAPGPIWTPLIPSSFDTNHVETFGSTTTMGRPGQPVELAPAYVYLASNECASFVSGEVIHINGGEIING
>NZ_CP013246.1|WP_012047589.1|392668_392785_-|hypothetical-protein
MYYLLLVFIHEKILKIAAIYINYNFMFNKDMLFRIYLV
>NZ_CP013246.1|WP_061311363.1|403387_404446_-|hypothetical-protein
MNLSDIITQATNLEQSLIKIQQTIEDLRTISTEIDEWENKNIEDILNINISDGSSNAIGNARTLRSKNREYYINFLQQLREINFFNSSFILSKMENKFEYFNMDRFIQIFIQCTEIIHKFTYSKSDNKVTPLFFQAIHSVNTIIKQYDNIIRDINKIKNIGYTLIGSEDEKNLKIRFLKEDNEVASLINNITLINSIYDNINSLIGDESEKLKYKRAESGTFEINLTGCINTLAVLLPMLKFSYNIYTENFSWKAKQERKLGEIKVRKEYLKLIKEVKEVKELNITDEVSIKNILGNLDENIKELFINNPCIQVNNERIGIEEMKEKNIPIELLKSSEKEIDTTLDADANNK
>NZ_CP013246.1|WP_071647222.1|404694_405465_-|SH3-domain-containing-protein
MLFNLNPGHTLSGGDVGTRGIGGLKEEVLTRQLVGEIDKELRGRGHSTNICRVDYASTLQESLNKQVALCNSVNADLNICIHFNTTVGGYGSEVYTYSGKYLVEADRVLEQLNNLGFRNRGIKDQPLALTKRTKAKTIYIEVCFIDSSGDVAILNKYGMNGIAKAIVNGVLGTSSNVTPSKSTDNNNNSWINLDGKTGTINTPSGVNIREKKSTSSKILGALPNGAKVQLYRKEGDWIHIYYPPHGGYVYAKYIRY
>NZ_CP013246.1|WP_071647223.1|405505_405679_-|hypothetical-protein
MNRVLTKITSARWLIAVIMTIVFAILAIRNTLNTEFITIYTMVVAFYFSKDRKEQDK
>NZ_CP013246.1|WP_021106501.1|405690_405915_-|hypothetical-protein
MDSNIQQEILERIVRIETKIDGYNSTREKADIAYNKACQNEKDIAEMKDNQKWLWRTIAGAIILGILGAVIKFN
>NZ_CP013246.1|WP_003394958.1|406082_407279_-|IS110-family-transposase
MISIGIDVSKGKSMVCIMKPYGEVIRMPYEIKHTKKDLSDLASMIMAFDEESRVVLEATGAYHLPVLNYLKQKNIFVAVINPLIMKKYASIAIRKGKTDKIDSIKIANYGLDNWFHLNNYSASDELYEELDMLCRQYNQYVSIKVKCKVNLVNLLDKTMPGITTLLRNHDYIGKYKLNSFVKEYWHYDNITKKSEKQFIASYLKWAKREGYHANEDKGKSIYALAQESITTLNPKMKSTKMLVTEAIRVFQEVEKTVRMILLQMQELAKKLDEYNIVREMQGVGDVLAPRLIASIGDIRRFHNAKALIAYAGIDTPPYESGNFKGTKQRISKRGSAYLRKTGYEIMASLKAIKPSVDSVVYDYILKKESEGKAKKVAKIAGLNKFLRIYYARVKEVYS
>NZ_CP013246.1|WP_003358830.1|408333_408585_-|hypothetical-protein
MLPEELLELIQNYIDGEYIYIPRKECNRKTWGENTESKRKISIRNSEIYKKYKDGISVKVLSEMYYLSPKSIQRIISNMSSEN
>NZ_CP013246.1|WP_075143902.1|408727_408895_-|hypothetical-protein
MRLLKGIKHILLGIAIILIGASFIISTDSSMGGYGEVILLIIGLAQCIRGVKMDD
>NZ_CP013246.1|WP_003358896.1|409814_410636_-|sporulation-transcription-factor-Spo0A
MEETKINVIIADDNKEFCNILSDYLLNQRDIMVTGIANDGVEALKLVEEKKPDLIILDIIMPHLDGLGVLEKLNSIDITPMPRVIVLSAVGQDKITQRAINLGADYYVVKPFDMDVFTKRIRQMFNNTISSEEVRRPVVMPETCSQEKISLSKNEPADLEQEITDIIHEIGVPAHIKGYMYLREAITMVVNDMELLSAVTKELYPSIAKKYNTTASRVERAIRHAIEVAWSRGQVETINNIFGYTINNGKGKPTNSEFIAMVADKLRLKNRVC
>NZ_CP013246.1|WP_003358985.1|411065_412292_-|SpoIVB-peptidase
MDRNKKKFLSFFLIPILLISLFTYYKIHHIPTTIFVREGERVKNNSFIKLTEDISADCTVSDIKSNNKKMNVKILGMVPVKSVSLKPVSKDIMLYPGGKPVGVKLNTKGVLVIALSDIETEGGKIQSPAAVSGIQIGDSIISINGKEITNSEDVEKEIRNCEGKDLKIVAYRKGEKITKNIKPEKGKKDNNYKIGLWVRDSTAGVGTLTFYHDKSKKFAALGHPITDVDTGTILTIDSGEIVPSSIVSIKKGIKGNPGELKGIFLDEDLVLGNIENNTECGIFGTSNVKLSNKKYKKPMKVALRNEIKEGPAQVLTTLEGEEPSLYNIEIQKLLSQDKPGPKSMVIKVTDQNLIKKTGGIVQGMSGSPIIQNDKIVGAVTHVLINKPDVGYGIYIEWMLKDAGILDNN
>NZ_CP013246.1|WP_003358866.1|412713_413610_-|homoserine-O-succinyltransferase
MALIIDKNLPAYQILKSENINIMDKLNYNKNTNKLKLIILNLMPKKIEAETQILRVLGKSFIDLEITFLKTESYKSKNVSNDHLNKFYKTFSEIKNHNFHGMIITGAPVELMDFERVDYWEELKNIMDYCNKKVKSTIFICWAAQAALYYYYDINKYSLNKKLFGVFPHKISKENSLLTKGFDDEFYVPHSRYTYTRKEDIKRCKDIEIISESEEAGLYLMQSNNFKKIFISGHCEYDRYTLYEEYIRDINKNKHIDIPKNYFKENNLNKKPIMRWRCHGETLFLNWIQLLEKLSSDS

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Crispr_ID: NZ_CP013246_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013246_2

698380-698607

TypeI-B

III-B:NA

Consensus_repeat	Method
TATTTAAATACATCTTATGTTA	CRT
ATTTAAATACATCTTATGTTACTGTTCAAC	PILER-CR

3 spacers

cas3,cas5,cas7,cas8b1,cas6

The CRISPR arrays of NZ_CP013246_2

>merge|NZ_CP013246|2|698380-698607|CRT,PILER-CR
TGTTTAAATACATCTCATGTTATTGTTCAACTGAAATATCTGGAATAAATCTATTTGACATATCACCATTTAAATACATCTTATGTTATTGTTCAACATATAAAGGTTTTAGTCATATAGATCAAAAAGAATTATTTAAATACATCTTATGTTACTGTTCAACGCACAAGCTAAATTAGTTTTTAATAATACACCCATATTTAAATACATCTTATGTTACTGTTCAAC

>NZ_CP013246|2|2|698380-698598|CRT
TGTTTAAATACATCTCATGTTA	TTGTTCAACTGAAATATCTGGAATAAATCTATTTGACATATCAC
CATTTAAATACATCTTATGTTA	TTGTTCAACATATAAAGGTTTTAGTCATATAGATCAAAAAGAAT
TATTTAAATACATCTTATGTTA	CTGTTCAACGCACAAGCTAAATTAGTTTTTAATAATACACCCA
TATTTAAATACATCTTATGTTA

>NZ_CP013246|2|1|698382-698607|PILER-CR
TTTAAATACATCTCATGTTATTGTTCAACT	GAAATATCTGGAATAAATCTATTTGACATATCACCA
TTTAAATACATCTTATGTTATTGTTCAACA	TATAAAGGTTTTAGTCATATAGATCAAAAAGAATTA
TTTAAATACATCTTATGTTACTGTTCAACG	CACAAGCTAAATTAGTTTTTAATAATACACCCATA
TTTAAATACATCTTATGTTACTGTTCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013246.1\|WP_003358211.1\|693297_694662_-\|PTS-ascorbate-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|236502
NZ_CP013246.1\|WP_080488619.1\|686789_688790_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376899
NZ_CP013246.1\|WP_071647321.1\|700234_702469_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP013246.1\|WP_071647326.1\|707347_708184_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013246.1\|WP_014521031.1\|711063_712470_+\|peptide-MFS-transporter	unknown	unknown	gnl\|CDD\|340904
NZ_CP013246.1\|WP_043032052.1\|709492_710107_-\|sugar-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100047
NZ_CP013246.1\|WP_071647323.1\|703201_704137_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|274215
NZ_CP013246.1\|WP_071647317.1\|690992_693086_-\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CP013246.1\|WP_071647316.1\|690313_690667_-\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|379915
NZ_CP013246.1\|WP_003485280.1\|694987_695425_-\|PTS-maltose-transporter-subunit-IIBC	unknown	unknown	gnl\|CDD\|238129
NZ_CP013246.1\|WP_071647320.1\|697195_697942_-\|cell-envelope-integrity-protein-TolA	unknown	unknown	gnl\|CDD\|236545
NZ_CP013246.1\|WP_003485279.1\|695448_696165_-\|transaldolase	unknown	unknown	gnl\|CDD\|183481
NZ_CP013246.1\|WP_071647315.1\|688770_689538_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NZ_CP013246.1\|WP_071647324.1\|704139_705870_-\|hypothetical-protein	cas8b1	mkCas0174_cas8b1_CAS-I-B	unknown
NZ_CP013246.1\|WP_071647322.1\|702486_703200_-\|CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|273860
NZ_CP013246.1\|WP_003361919.1\|694674_694959_-\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99905
NZ_CP013246.1\|WP_071647318.1\|696398_696806_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013246.1\|WP_155119182.1\|705873_706620_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_CP013246.1\|WP_155119201.1\|710430_710634_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379790
NZ_CP013246.1\|WP_071647327.1\|708953_709448_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP013246.1\|WP_003358211.1\|693297_694662_-\|PTS-ascorbate-transporter-subunit-IIC	gnl\|CDD\|236502	PRK09410, ulaA, PTS system ascorbate-specific transporter subunit IIC; Reviewed.	0
NZ_CP013246.1\|WP_080488619.1\|686789_688790_-\|ABC-transporter-permease	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	0.0016534
NZ_CP013246.1\|WP_071647321.1\|700234_702469_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	9.04737e-77
NZ_CP013246.1\|WP_014521031.1\|711063_712470_+\|peptide-MFS-transporter	gnl\|CDD\|340904	cd17346, MFS_DtpA_like, Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters. The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	9.02096e-120
NZ_CP013246.1\|WP_043032052.1\|709492_710107_-\|sugar-O-acetyltransferase	gnl\|CDD\|100047	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).	4.37512e-98
NZ_CP013246.1\|WP_071647323.1\|703201_704137_-\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|274215	TIGR02585, conserved_protein, CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This clade is a member of the DevR family (TIGR01875) and includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to be regulated through a number of means, including both location and autorepression; DevR mutants are incapable of fruiting body development.	9.523e-41
NZ_CP013246.1\|WP_071647317.1\|690992_693086_-\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	8.76177e-58
NZ_CP013246.1\|WP_071647316.1\|690313_690667_-\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|379915	pfam17032, zinc_ribbon_15, zinc-ribbon family. This zinc-ribbon region is found on a set of largely microsporidia-specific proteins.	0.000160235
NZ_CP013246.1\|WP_003485280.1\|694987_695425_-\|PTS-maltose-transporter-subunit-IIBC	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	4.79769e-38
NZ_CP013246.1\|WP_071647320.1\|697195_697942_-\|cell-envelope-integrity-protein-TolA	gnl\|CDD\|236545	PRK09510, tolA, cell envelope integrity inner membrane protein TolA; Provisional.	9.21399e-12
NZ_CP013246.1\|WP_003485279.1\|695448_696165_-\|transaldolase	gnl\|CDD\|183481	PRK12376, PRK12376, putative translaldolase; Provisional.	6.47741e-157
NZ_CP013246.1\|WP_071647315.1\|688770_689538_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	4.0271e-103
NZ_CP013246.1\|WP_071647322.1\|702486_703200_-\|CRISPR-associated-protein-Cas5	gnl\|CDD\|273860	TIGR01895, conserved_hypothetical_protein, CRISPR-associated protein Cas5, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family is represented by TM1800 from Thermotoga maritima. It is related to TIGR01868 (CRISPR-associated protein, CT1976 family).	2.02534e-13
NZ_CP013246.1\|WP_003361919.1\|694674_694959_-\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99905	cd05563, PTS_IIB_ascorbate, PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a transmembrane channel IIC subunit. Subunits IIA, IIB, and IIC are encoded by the sgaA, sgaB, and sgaT genes of the E. coli sgaTBA operon. In some bacteria, the IIB (SgaB) domain is fused C-terminal to the IIA (SgaT) domain. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include ascorbate, chitobiose/lichenan, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	2.52704e-28
NZ_CP013246.1\|WP_155119182.1\|705873_706620_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.98156e-08
NZ_CP013246.1\|WP_155119201.1\|710430_710634_+\|hypothetical-protein	gnl\|CDD\|379790	pfam16189, Creatinase_N_2, Creatinase/Prolidase N-terminal domain.	2.27038e-11

>NZ_CP013246.1|WP_071647320.1|697195_697942_-|cell-envelope-integrity-protein-TolA
MDKFRNMKKSHIALLVVMYMVLMGSLPRFTGWATIFSAIAVGGYFLKNKKDLKELTNKKKNFIFTGIIILAIIGSFNVAVGNNIQNEKLLAEKSKQEQQIKKEQEEKKLAEEQKRIQEEEAKKKAEEEKRKQEEEAKKKTEEEAKKKALEEQKKQEELKRKQEEENKIKAENEQAQAAFAQSTGKGNSNDQSNESENVDNNQNYTVYKTRTGSKYHSSGCRYLRKSCYETTVSQARNEGLTPCSVCNP
>NZ_CP013246.1|WP_071647318.1|696398_696806_-|hypothetical-protein
MNILISTCNIGIPVLMILIGILYKCNLYKKIDRTLDLIVPMVTFFTGFSERDREHLYKNTNNLASVNRKCSLIWSISGVCTLLLTIIISLILNKSDIYNTSVILLEPELLILVIVFITVEYILKRNFNKKISEQY
>NZ_CP013246.1|WP_003485279.1|695448_696165_-|transaldolase
MKYNDLKIKIFADGADLNGMLDAYNKGIVKGFTTNPSLMKKAGITDYKEFAKEVLAKIKDMPVSFEVFSDDLETMEKEAEVLGNLGENVYIKIPVTNTKGESTAPLIKKLSEKGYHLNVTAIFTIDQVKEVVEALKSGVDSIVSVFAGRIADTGEDPVTIMKEASKICKTKEGVELLWASCREFYSIVEADKCGCEIITVTNDILKKMPNMGKDLKEYSIETVRGFYKDASSLGFSIL
>NZ_CP013246.1|WP_003485280.1|694987_695425_-|PTS-maltose-transporter-subunit-IIBC
MLKNYINDQVVEVNVEVKNWEEAVRLGGKLLEEDGAVEHSYIDAMVDTVKNMGPYIVIAPGIAMPHARPEAGAKNIRIGLLKLKNPVNFGNEEHDPVDIVIFLCAVDNKAHIEVLGELVQLIEDDDFLKIVRNASTKKEILDYIK
>NZ_CP013246.1|WP_003361919.1|694674_694959_-|PTS-sugar-transporter-subunit-IIB
MNILTVCGNGIGSSLMLAMKIEEICKENGIAANVESTDFNSAQGKKADLIVTVKELAEQFEGRDVAVVRSYINKKKITEDVLEIIKQKDEELKK
>NZ_CP013246.1|WP_003358211.1|693297_694662_-|PTS-ascorbate-transporter-subunit-IIC
MLGLLQFLRDVLKQPALLMGIMALVGLVALKKPGHKVLTGTLKPILGYLMLGAGADFIVANLEPLGGMIQTGFNITGVVPNNEAIVAVAQKVLGVETMSILVVGLLINLVIARFTKYKYVFLTGHHSFFMACLLSAVLGTSGMKGTELILFGGFLLGAWSAISPAIGQKYTLKVTDGDEIAMGHFGSLAYYVSAWVGSKVGKPEESTENIEIPEKWGFLRDTTISTAITMMVFYIVAAVAAGPEYVSKLSDGMSPILFAIMSSLKFAVGVTIVYNGVRMILGDLIPAFQGIATKIIPDAIPAVDCAVFFPYAPTAVIIGFVSSFIGGIIGMVLLGVAGGVLIIPGLVPHFFCGSTAGIFGNATGGKKGAVIGSFVNGLLITFAPALLLPVLSTLGFKNTTFGDFDFGVLGIIIGKTSNLAGKTGIIIIAMLMLVALIVPNFIKTKSKALNNIEE
>NZ_CP013246.1|WP_071647317.1|690992_693086_-|BglG-family-transcription-antiterminator
MLNKRCSNILQMIVNNEKPITIKEISKKVNKSPRTVRYDLDKIDDYLTEIEFPKLERKSNLGISLDLKDEEIKKLFQIIGKINNYDYVLSQKERVFYIIYELLNKSEFVTINMLSDRMMVSRSTIINDLIEVKKWLSENKITLESSKGQGIKILGMERDLRRAAVKLFFQSMDSINFFNVTTLKLFNDIDIDFIRNTIKIAEEQMETSFSDDAFNNLVIHIAIAIKRIELSKDIIMDSEELKNLRKTAEYAIASGIAKMLEDRFKISIPEDEIGYITIHILGSNTSTLENIVKDDWIYLHLIVFKLIENVENITGINFSKDNKLFDSLAQHIRPAIYRLKHDIKVKNPLIEEIKEKYSYIFESIEEGVKFIEEDIGDSVNQEEIGYLTLHFMASIERSKNKKHRKPNVLIVCATGIGTSKFISNKLKSIFDINIIDTISSHTMEKILKYNKNIDLIVTTIPLKVKGIKCIEVNTFLTEKNISELGLYFAKFIRNNSEECNGSCKYEERDKVQEILNIVKENCTIHDYYKLRNKLALYLNIKDPTLTEDHKPSLKELLKSDFIRLNEEAEDWEDAVRKSGEILMNNGCIKKSYIDAMVNTVKNMGPYIVIAPGIAMPHAAPEDGVLKTGISMLTLKDPISFGNSEHDPVSVIISICSIDKVNHMKALKELMSIMDQEDFISKVKNIKASSEIDSILYS
>NZ_CP013246.1|WP_071647316.1|690313_690667_-|zinc-ribbon-domain-containing-protein
MIIWGWGKVTKKVIGAVFERTCNYCNTDEVWNLCVVRTWFTLFFIPIIPYKKQYCIACPKCWSYIELTQEEFEKIKIDITSSSNNINEKVVTDNIKYAGKTETQINYLKQMEEYANK
>NZ_CP013246.1|WP_071647315.1|688770_689538_-|ABC-transporter-ATP-binding-protein
MQNILSVEKIEKYYGNKDNVTKAIDNISFKVDEGEFVGIMGPSGSGKTTLLNCISTIDNVTTGKIMINNNDITRLKSKSLDKFRQNELGFIFQDFNLLDTLTAYENIALALTIQGEKTSKVDGKVKSVAKYLEIEKVLGKYPYQMSGGQKQRVASARAIVTNPSLILADEPTGALDSKSARLLLERFEKLNKELKATILMVTHDAFAASYAHRILFIKDGKIFNELVRGNDTRKEFFNKIIEVTSLLGGDDNNVF
>NZ_CP013246.1|WP_080488619.1|686789_688790_-|ABC-transporter-permease
MIIMYSKIALKNIKKSYKDYTIYFLTLILAVCIFYSFNSIDSQKALTDIKSSGGSYVSKLMDFMSAVSVFVSIILGSLILYANNFLIKKRKKELGIYMILGMGKRKISKILVTETSIVGAISLIAGLIIGMGVSQGLSVFALKLFEVSINEYRFAVSTRAISKTILYFGVMFLLVMIFNVFVISKYKIIDLLTSGRKNENIKFKNPFIYLLSFLLCVVLLGFAYKSILKTGLKLREPMFKPSIAFVIVGTVLFFFSLAGVILYVVNKNKKIYFKGLNMFVVKQINSKVNTNFLSMSLICLMLFITILVLSTGISLKNGVEEGAKIKAPFDASIIISNNSKKDNLEDVLDKINFKRGKNEKYATCNNYFSGIKLESLLPITDKDYKYAEVSFVKISDYNKMLKLKGKKEINLNKDEILVMSTNNNMVKQANEKLKNSKKFNIKGKEYLVKNDKIIDENLATYLLADNVFTVIISDEFLYDYNEISYSILNVMYSDKNREKNNKKYREINKNYLDGKYKSLNISYMGAFSKDDIYSHSKGGTTTVLFVGIYLGLVFLITSMAVLALQQLSEASDSIERYKALKRIGANSKMIDKTIFLQTFIYFTLPMILALIHSMIGIKVISDYIEVFTKIDISFSALITALIFSVVYAGYFYTTYIGYKNIVESNI
>NZ_CP013246.1|WP_071647321.1|700234_702469_-|CRISPR-associated-helicase/endonuclease-Cas3
MSEVIAKKTKNEATQTLEGHTFMVIEAALSLIDDKEIEFISKETGYGKNKIKDLIFFFTYFHDIGKATYEFQDTIKNESKSYHSLYSSSLFSNITDFEVDEDYGINMLMLCILTHHSIFNVESSFKTVGNNKKFNFKFLPYAEIFFYNYKEAYEKYLNKVCNYEFKYEEIDLKELGKEIEELYDDIDNLRKYESCSRIRLLYSYVSGILNLADWIASAKFNNSLTKIKFDYLIDKKELCRRFAESIKINEFIPKEFQEKLSNCKGSVLVEVPTGEGKTEGAFLWAVNNIDNELRSKIIYTLPTQTTSNKLYERVKDVFFDNTGLIHSSSKIYLEKKYEQENGKVDDKFQSDILFSTTFNKGATVSTIDSLFKYFLNIGRYNIAMLNFFRSVIIIDEVHSYDFKLMGFMKRFLELCKYYNVPVCLMSASIPNKIKELLNIEKLPIVSDEKLFEKKANYIYKVDDSLDNKFEDVIEKFNKGKDILIVRNKINKSIEAYKELKKRGIENIILYNSQFKKKDRVKKENEIYEKLKNKEHFILIATQVVEISLDIDFDVMFTDNAPIDSLIQRFGRVNRKKKQDKIGEIYIFRDTDIKPYYLRMLEITYDTLEEGLFSLGKYTKWLNKVYDELFNDKKVINELETKFVEEYQKFNKVLSELHGISQSKDIYDLRDIESPKKDYILCEDYDKDIYDYENTISLPTYLSQSKYSLADKDYAKGIYYDVLNLEYNYEIGAIIEDSEDDIFLD
>NZ_CP013246.1|WP_071647322.1|702486_703200_-|CRISPR-associated-protein-Cas5
MKVIKFSVEGIFNSFRVPFFRTYHKSFLAPPKTTIIGLITNIMGKSEVYYYKLLNEEKIQVSVVINSIKGKAKDLWSYKSLESKSNMHGRSIIRRDKLFNAKYTIYLMIQDENLRQEVLECLKAPKSIPSLGLDDELIKIYDVQSDVELKDNDTDIINSVFMDKAYNYKVKVKDLSSDIEFPTANIVPLKYKIKANKESRTARESCDEYKQIEYMNCEIELKDVKSFICSTDKVVFY
>NZ_CP013246.1|WP_071647323.1|703201_704137_-|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MFYNIATISKVNLGSLNGSEGVGGNITPIKKITDNQGEEYAYISGQAQRRYYKETLSQLGERITAVNEKGNPNFLEHDDKIYDKKKEKFENKELMYKEFCDLDLFGYMLPNGGRRWSPVKVSPMVSIHPYKGEYDYLTRKQYVKDEGKKSGNIVQIEIDTLNYMRGNILIDVDKIGKEINEYTYGVTSILSEKETNNRINKLVDAVRFFNGGAKQARNLEDISPKFVVAVKQKTGNPFLLNSIYVDKYNNLDAQAIIDEIKDNEAVVINTAVGLARNIFANENEIKEEFNKAGIKVFSVTEALNSLKIGVE
>NZ_CP013246.1|WP_071647324.1|704139_705870_-|hypothetical-protein
MILSDKFVMKEFTKRDVFYNNGLVNLKSYLETYSIEGLCCELNNEKLILKYPEGMDDKYYNDIFKGFIINNNIVFHTDNDRLYWDRNNNCFIYDRKYDVKGKSSGNDVKNLYKYITPTEIGKNIEEIFNEYIEFAKQHSLNNKNIADDTKTFKKGSSYKKENQCKIPILMTKSEAVERYIEYSVKGNMLKFDSKIHQFEDGGDCFRDMIDNKNNFIDKWDALIYWYGVKMKRYYNSSYFIYLNSTDLLALYEMKQHLDIKDDAITIKDEKKGKVKSIPTNVNLTKQLKFDGIENENFYISNSAKEFEVKFFMYLVSHIYHIEKIYENTAKERVRKRKERLYNSFPKISFVTYTEDGNMKSQLEEYTKAYKMMMLLNKLLETKYSDSTLFRYLSNLITSITMSKSERENINLNIKKFCDNILKFTDLRKVYYEVSFKVLKNNKRTLGAGLYEFENLYLNEIKRGDYVMSLHSKSKEIGREIGLFAANLEEKDLLFKLRNVKNHKQMVTYFKDLKFTVLKKQSEAKFTKKFSDIMEEILINMEDKPDSWEIIRDYIAIYAIDKYKAAVYAKQAVKGGK
>NZ_CP013246.1|WP_155119182.1|705873_706620_-|CRISPR-associated-endoribonuclease-Cas6
MQKIIKMFIIDYGRGEIMRFFQLTTTVLLKDNIHFSKSSEIIGNTISRAMLNDEKLKELHKHKGYKYVFDNLYPLEKDGIYKEKRIYIFNIRSFNEDYVIKIKHCFNGFENSYMKIISTDLRTIKRKPINYIETITPAVVTVDSKPWLSDGDILLLVKRLHANAEKKFKFFFHEEIEEVEDYFIEKLKILNKKPIAYSYKNIKLLANKVRIKVNEDDISQKLAFTVLGGGLAEKNSIIGAGFCKCDWR
>NZ_CP013246.1|WP_071647326.1|707347_708184_-|hypothetical-protein
MVKMTFEVGTIVVAVITGIITLIGVIINIILIKSQSKKQRTAEIITRNRVEWMQELKKYVSEYNSLVCYYYDKKIPDNLNDYFEKINNSTSKIKLHLNLKGIHDKKIKQIIEDLNSSLERFLQLTKYKETCNPNTNKKMHMPKELIEFYFNQYPNIGFKAHKEIFKEDKVYLMTEAELKQYLIDNKNNESTVMTRFISYVVKCIDEDLNKCVDKMKYSPKLIILLTQIYLKTEWERVKIEAEKGNKATFKFDKVYNEIIEQVQDEIDELERLINKKVR
>NZ_CP013246.1|WP_071647327.1|708953_709448_-|hypothetical-protein
MILAIECFIACLIFTLIILPSLYKEPIKHIMSYPTEIRKRVESLPQYKDVIQKKEKKHLTVKIIAVFMFAIILAVVAYFSGAKSFLKAYIHVFTLFFVVNIYDMIVLDIGLFCHSKKTRIPGTEDMDKEYRNPWHHIKGAGIGTIIGAVVALLSGGMVHFISII
>NZ_CP013246.1|WP_043032052.1|709492_710107_-|sugar-O-acetyltransferase
MNQKDRMLAGLPYKACLDGLPEERMANKKKIYEYNHCFPDEHEKIHKLIRDILGKAGADVHIEAPFYCDYGKNIQVGDNFFANYNCTILDVGKVIIGNNVQFAPNVSLYTAGHPIHPDSRNSGYEYGIGITIGDNVWLGGNVVVNPGVHIGNNVVIGSGSVVTKDIPDNVIAIGNPCKVIREITEEDRKYYYKNYEFDVDDYKG
>NZ_CP013246.1|WP_155119201.1|710430_710634_+|hypothetical-protein
MHLFINKNKLSDKIKSSLKKNAALFIHPYNKIYKEVKKFTNSDVVLVDQARMNYALYNNIPEQELMY
>NZ_CP013246.1|WP_014521031.1|711063_712470_+|peptide-MFS-transporter
MSEKKQKHPIGLWLVNISIALQSYAAYAVVSILILFLTADVSKNGLGLSVPKAAAIIGLYQGINYMGSLVGGYITDKWLGIQKSLILGCFLTACGYLALFFAKPNIGSVWLGLIILIVAGAFFKAQISSLVGELYGKNELSKKDAAYSIFYMFINIGAFFGPIIAGLISDKWFAKVAADGEIAAYGYKYIFLMCTLIMIFIGIFIWIVSPKWLGEIGKYPVSKDKKTSTESVSTKSTEKAKAQPLTQLEKNRIKAMIVMFVFVIIFWSAWDQTATSFSLLANKLVNRTIGGFTMPVPWLTSINAIFCVVLSPIIANIWLKLGNSKKGDLSVPTKMGLGMILTGIAFLTLILGISTLGGVLDGSKQMNILFIIVAYFLLTVGELCLSPIGMAMFNKLAPAKYGSLAMGAWYLSFFFSSIISGKLAGFTDTLGYTQIFGLISGIVIVFGVILILLRNGLLKLMSLDELDK

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Crispr_ID: NZ_CP013246_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013246_3

734916-735207

Orphan

III-B

Consensus_repeat	Method
ATTTAAATACATCTCATGTTATTGTTCAAC	PILER-CR
ATTTAAATACATCTCATGTTATTGTTCAAC	CRISPRCasFinder
ATTTAAATACATCTCATGTTATTGTTCAAC	CRT

4 spacers

The CRISPR arrays of NZ_CP013246_3

>merge|NZ_CP013246|3|734916-735207|PILER-CR,CRISPRCasFinder,CRT
ATTTAAATACATCTCATGTTATTATTCAACTGTTAATAAAGTGGCAACTGGATTTATGAAAATGTAATTTAAATACATCTCATGTTATTGTTCAACTGGGAACAGTTCGACAACCTAGAGTAAACTTACTTTATTTAAATACATCTCATGTTATTGTTCAACTAGAAAGGATAGTAAATAAATTTGAAATCAGAACATTTAAATACATCTCATGTTATTGTTCAACGAAATGTTTTAGAAAGGATATGTGAGATATGGAGGAATTTAAATACATCTCATGTTATTGTTCAAC

>NZ_CP013246|3|2|734916-735207|PILER-CR
ATTTAAATACATCTCATGTTATTATTCAAC	TGTTAATAAAGTGGCAACTGGATTTATGAAAATGTA
ATTTAAATACATCTCATGTTATTGTTCAAC	TGGGAACAGTTCGACAACCTAGAGTAAACTTACTTT
ATTTAAATACATCTCATGTTATTGTTCAAC	TAGAAAGGATAGTAAATAAATTTGAAATCAGAAC
ATTTAAATACATCTCATGTTATTGTTCAAC	GAAATGTTTTAGAAAGGATATGTGAGATATGGAGGA
ATTTAAATACATCTCATGTTATTGTTCAAC

>NZ_CP013246|3|2|734916-735207|CRISPRCasFinder
ATTTAAATACATCTCATGTTATTATTCAAC	TGTTAATAAAGTGGCAACTGGATTTATGAAAATGTA
ATTTAAATACATCTCATGTTATTGTTCAAC	TGGGAACAGTTCGACAACCTAGAGTAAACTTACTTT
ATTTAAATACATCTCATGTTATTGTTCAAC	TAGAAAGGATAGTAAATAAATTTGAAATCAGAAC
ATTTAAATACATCTCATGTTATTGTTCAAC	GAAATGTTTTAGAAAGGATATGTGAGATATGGAGGA
ATTTAAATACATCTCATGTTATTGTTCAAC

>NZ_CP013246|3|3|734916-735207|CRT
ATTTAAATACATCTCATGTTATTATTCAAC	TGTTAATAAAGTGGCAACTGGATTTATGAAAATGTA
ATTTAAATACATCTCATGTTATTGTTCAAC	TGGGAACAGTTCGACAACCTAGAGTAAACTTACTTT
ATTTAAATACATCTCATGTTATTGTTCAAC	TAGAAAGGATAGTAAATAAATTTGAAATCAGAAC
ATTTAAATACATCTCATGTTATTGTTCAAC	GAAATGTTTTAGAAAGGATATGTGAGATATGGAGGA
ATTTAAATACATCTCATGTTATTGTTCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013246.1\|WP_071647344.1\|732927_734391_+\|lipase	unknown	unknown	gnl\|CDD\|335313
NZ_CP013246.1\|WP_003358347.1\|736075_736522_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP013246.1\|WP_003358441.1\|735541_735994_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378897
NZ_CP013246.1\|WP_071647339.1\|724405_724699_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013246.1\|WP_003358280.1\|739393_740716_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP013246.1\|WP_012100172.1\|745579_746365_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|224997
NZ_CP013246.1\|WP_053338241.1\|728284_729133_-\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461
NZ_CP013246.1\|WP_071647338.1\|723560_724358_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133378
NZ_CP013246.1\|WP_071647342.1\|729409_730330_-\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461
NZ_CP013246.1\|WP_003358167.1\|738153_739053_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013246.1\|WP_071647345.1\|742931_744218_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226458
NZ_CP013246.1\|WP_003358390.1\|734425_734809_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133398
NZ_CP013246.1\|WP_003485240.1\|724873_725323_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP013246.1\|WP_014521061.1\|744511_745561_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NZ_CP013246.1\|WP_076045449.1\|736689_737736_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NZ_CP013246.1\|WP_071647343.1\|730654_732148_+\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP013246.1\|WP_025775915.1\|740783_741518_-\|protein-kinase-family-protein	unknown	unknown	gnl\|CDD\|270622
NZ_CP013246.1\|WP_003358486.1\|742020_742794_-\|2-hydroxyglutaryl-CoA-dehydratase	unknown	unknown	gnl\|CDD\|224835
NZ_CP013246.1\|WP_071647340.1\|725461_725878_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP013246.1\|WP_080488620.1\|726387_727320_-\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349913

Protein	Function_ID	Function_description	E-value
NZ_CP013246.1\|WP_071647344.1\|732927_734391_+\|lipase	gnl\|CDD\|335313	pfam03403, PAF-AH_p_II, Platelet-activating factor acetylhydrolase, isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.	6.3488e-18
NZ_CP013246.1\|WP_003358347.1\|736075_736522_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.36279e-14
NZ_CP013246.1\|WP_003358441.1\|735541_735994_+\|hypothetical-protein	gnl\|CDD\|378897	pfam12638, Staygreen, Staygreen protein. This family of proteins have been implicated in chlorophyll degradation. Intriguingly members of this family are also found in non-photosynthetic bacteria.	4.18402e-85
NZ_CP013246.1\|WP_003358280.1\|739393_740716_+\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	3.674e-27
NZ_CP013246.1\|WP_012100172.1\|745579_746365_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	7.85324e-97
NZ_CP013246.1\|WP_053338241.1\|728284_729133_-\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	2.387e-61
NZ_CP013246.1\|WP_071647338.1\|723560_724358_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	3.19942e-15
NZ_CP013246.1\|WP_071647342.1\|729409_730330_-\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	3.03068e-89
NZ_CP013246.1\|WP_071647345.1\|742931_744218_-\|hypothetical-protein	gnl\|CDD\|226458	COG3949, COG3949, Uncharacterized membrane protein [Function unknown].	8.05894e-29
NZ_CP013246.1\|WP_003358390.1\|734425_734809_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133398	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators. Helix-turn-helix (HTH) heavy metal resistance transcription regulators (HMRTR): MerR1 (mercury), CueR (copper), CadR (cadmium), PbrR (lead), ZntR (zinc), and other related proteins. These transcription regulators mediate responses to heavy metal stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	2.00619e-33
NZ_CP013246.1\|WP_003485240.1\|724873_725323_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	5.04072e-36
NZ_CP013246.1\|WP_014521061.1\|744511_745561_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	6.84745e-134
NZ_CP013246.1\|WP_076045449.1\|736689_737736_-\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.33095e-89
NZ_CP013246.1\|WP_071647343.1\|730654_732148_+\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	2.01647e-118
NZ_CP013246.1\|WP_025775915.1\|740783_741518_-\|protein-kinase-family-protein	gnl\|CDD\|270622	cd00180, PKc, Catalytic domain of Protein Kinases. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.	1.5134e-24
NZ_CP013246.1\|WP_003358486.1\|742020_742794_-\|2-hydroxyglutaryl-CoA-dehydratase	gnl\|CDD\|224835	COG1924, COG1924, Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism].	2.63017e-97
NZ_CP013246.1\|WP_071647340.1\|725461_725878_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	2.06775e-11
NZ_CP013246.1\|WP_080488620.1\|726387_727320_-\|M28-family-peptidase	gnl\|CDD\|349913	cd05663, M28_like_PA_PDZ_associated, M28 Zn-peptidase containing a protease-associated (PA) domain insert and associated with a PDZ domain. Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This subfamily is composed of uncharacterized proteins, many of which contain a protease-associated (PA) domain insert which may participate in substrate binding and/or promote conformational changes, influencing the stability and accessibility of the site to substrate. Proteins in this subfamily are also associated with the PDZ domain, a widespread protein module that has been recruited to serve multiple functions during the course of evolution.	3.77698e-44

>NZ_CP013246.1|WP_003358390.1|734425_734809_+|MerR-family-transcriptional-regulator
MNKMTRGELARQTGISTSTIRYYEDSGILPAPKRIANGYRIYTDDYLVKIKFIKDAKSLGYSLKEIKEILKMLSQEMDGENLKGLVKNKICEIEERIKTLHSIQRMLTDLLNTSEEDIQNYLQSFRI
>NZ_CP013246.1|WP_071647344.1|732927_734391_+|lipase
MRMLEVILFLVILAATGGILFVKPNRRLDIVFLMSVVLVMLLHGTINHFRIQMVPSYAVTLMLIMVLIHRLIKSNSKPKSQSIPKSLFKKSFISILVLIFICTSAYLSFLLPVFTMPKPAGNYGIGTVSAHLTDESRAETLSTSPDDKREIMVNVWYPVDQKDIKGKTVEHYPSELGEAISLVFNIPKQLFTHLSQVSTHVVQGAKISTVESKYPVLLFSPGVRSTRFQSLTTIEELVSHGYIVVGLDHPYTSAKITFPDGRSIFYKPDTKSMTASELYKHNIGNVGFRVADVRFLLDTLTKWNKKDPNALLQGKLDLERIGMFGHSYGGATTAEALSQDNRLKAGVSLEGGFWGSVSQKGLKQPFMYLMSGGTAASFDPSTIKKDKVFYEEFIPDLQSVINKSTNNIYYLTVDHFIHQSFTDISLMFPLLFAKGIDPVHNIDITRSYVRAFFDQYLKGNHSILLDGPSSKYPEVKFSDIYTKKRLN
>NZ_CP013246.1|WP_071647343.1|730654_732148_+|PLP-dependent-aminotransferase-family-protein
MNIKIDKTSLITITQQLVHYFSDRIMSGFIKAGQKLPSIRSLAKELGISPMTIIKAYNNLEQNGLVTTIQGKGTYVNERNSTVKSNNITEKDSFQWQMSVPDYLSRSQFRYNPNLSYSNDYYNLSVASLNHKLLPTKTILKDSLGLIQNDIKLLSQYPPAQGDYEFRNIMSQYLRSKEIATSPENILVTSGSQQGISIIASTFIGPGDIVVMETPTYPGAIDLFKCRGAVILTVPVDSEGMRTDILMNLCDKHSPKLIYTIPNFHNPTGYSMSSKRKAELLDIARYNDILIVEDDPWNEISYKREKIKTIKSMDTDGHVVYIKSLSKILGPSYRLAVIISESSILSRLIAAKANHALGTSVLIQKTIINFIQSNKITYYIESLNKQLVKRRDKVISLLKSHAPSGMKWAIPEGGINIWVTLPKNFNVEKLLSYSITTKNISFLPGTICYPNEVEFNNLRICFTYLDEEFIEDTIIELCNLIKLLYTTKNITDYRPII
>NZ_CP013246.1|WP_071647342.1|729409_730330_-|PhzF-family-phenazine-biosynthesis-protein
MRKFEYTLVDVFTNQVFGGNQLAVFKDAEKLSSEEMQSIARELNLSETTFVTDIGPNHKKLRIFTPKTELPMAGHPTIGTAFVLADEGAIETREGINKLIFEEGVGEIAVSIHVEGGRIRSIEMEQPMPVFGQVFEDIRTAAELLSLDIADIDTTSPIQTVSTGVPFLYIQLKSLDVISKIKLRLDTWEKFFSSSEDTKHIFAFTRETLHAGSTIHSRMFAPAMGIAEDPATGGASGPLGAYLVEHGLVAHGYDGKYMIINEQGIEMGRPSFINITVSKTYNNFSEIKIGGTCVKFGAGLIELPTL
>NZ_CP013246.1|WP_053338241.1|728284_729133_-|PhzF-family-phenazine-biosynthesis-protein
MEYFHVDVFSNEILYGNGLTVVFCNEELEDNLMLKLTQEFKQFETIFVRRIDNSIFNARIFTVDEELDFAGHPILGAAATIHSHIFRNEEDIAITFQLNQKTIIVNSKKIEEYYEVQMNQGKAEFLCEVSKEKRNKYVHALNLSEENLSEEFPMEVVSTGLPYLLVPLTSGIENAKIISSKFEEMLKEVGAKFAYIFDVNYIEGRTWDNQGNVEDVATGSAAGPLGAYLYKHNIFNVGHEIIINQGRFVGRPSKIKVSMSISEKEILVSGEVAILAKGTILL
>NZ_CP013246.1|WP_080488620.1|726387_727320_-|M28-family-peptidase
MKSTESNGKTVTDEQSSKSTQVETHVKIPTTKEIVNTLCSDEFEGRLIGSKGNDKAGEYVNKIFKDIGLDPLFGNSYYEKYSQDIIKVYGGGEDSKMGTINNVVGVIKGKNSKKAVVISAHFDHIGYQDGKIIRGALDNASGMSALIKVANNLKEKSKEKPFDMDIVICAFNGEEEGLAGSRAFVDEIISKSLYENLYNINIDSIGSKNGGKLALKNKSKVSNKLYASVKTTLKKNNIEFADTTIRGASDHMSFENEKIPNFFFVQENIKELIHKPTDTPDTLDYEQIDRIANAISDFVETNNGIMFGAK
>NZ_CP013246.1|WP_071647340.1|725461_725878_+|carboxymuconolactone-decarboxylase-family-protein
MARITFSQEGLTPFQQLLSHNKYIMGKWTSLEECFFNSNTFTHELKEEVRRTLAFNNGCQYCMSKGKPSNEITNSKILIATKIADIISKNQLIDNEYFNRLKNEFSDNEVSELLALICFITASQKFGALLDLQPSCSI
>NZ_CP013246.1|WP_003485240.1|724873_725323_-|Lrp/AsnC-family-transcriptional-regulator
MKLDEIDVLILQELQKDSRLSIRELSKRINLSPPSVTERVRRLEDDGVIEKYTIKINKKKLGLSIDCIVKVTMKNGQYEKFKIFIKEYKRSEWCYRIAGDGCFLVKLLVKSLNDIEEFINDISSYAITETIIAFSEVTINNSINKFLGE
>NZ_CP013246.1|WP_071647339.1|724405_724699_-|hypothetical-protein
MNFFTLNILIGAMAFIINKINNMSQDIDPFEAFNDIEENLDEIDNEKVTNFVNGLINASMSNPSIGYFFMFLVYITPILNLLLLIKGIVNYFNKAEG
>NZ_CP013246.1|WP_071647338.1|723560_724358_-|MerR-family-transcriptional-regulator
MRYSITDLAEILGCTTSAIHYFEKKHLIEVEKGKNGHRYYNVVDVFRLLSYTKYRSMEIPMKTIIAQFGGEENNYKLIEKRETMYQLEALKRAQYYMNLADAIEEHLVSIRRIEELLNKYEFAKSPEVTIMCDDECGWLSKKRSSQRIIHEWVKAMPTVQLGVFDSRMAMSNFGYLVKTKKREELELPLGLHAKEIKSTSCIHTIVMADEDFTQQPQKVFKKASEFAIKKGLEIGEIAWGKILLVEVEKGAKLHPYIELWISIKI
>NZ_CP013246.1|WP_003358441.1|735541_735994_+|hypothetical-protein
MSKLNPEKLSVEFRDGVTNTEPILGRRYTLTHSDITAELFLTIGLTYAYDKIDAMRDEVLGEWIEKEKNYLFHVYLHVDGNNPIVTGVRNHIFRRELPLALEAIRYGDRKFFISHPKLDNSSVIVHFISSYPSFNRIEKWGTFSDYSLKK
>NZ_CP013246.1|WP_003358347.1|736075_736522_-|helix-turn-helix-transcriptional-regulator
MSLGEKLLYLRKKASLSQEDVAEKLSVSRQTVSKWETDQTVPELNKAKLLSELYNVSYDYLISENYISGDVTGIEMIVDEIDWTGAWSKKYPILASYPGIKGINTYSEKISEIYDSFKNEFGFNDTDTVLVLKDILYQKYKMEKKKNK
>NZ_CP013246.1|WP_076045449.1|736689_737736_-|alpha/beta-hydrolase
MEVNEVKKVIKVVSVILVILVIAGFFIIKNLTETKDGKLNMYVAANLQLYKILNPKSLNSKSIEETRGALNKQSTRWSNKPIPFSNIKNLHIKMNNEKIPVRIYTPEKGSNFPIIIYSHGGFWIGGNVDTIDGVCRKLSQNTKAILISVNYRLAPENPFPAGLNDVYNVLQWTYKNGKSINGDEKHIAVVGDSAGGNLSAAVSSMSRDKNGPPITCQVLIYPSTNISELNSKSWSYFSNSFNVSTEDMEKYISIYAPKKEDRKNPYASPLLSKDLRKLPDTLVVTAEIDPLRDEGEAYANKLKESGVKAEVTRYKGITHGFITMDKITNKADEALNQISLYIQKEFQK
>NZ_CP013246.1|WP_003358167.1|738153_739053_+|hypothetical-protein
MSNKRNLQSLRSFYICILIFNMVSNSIFHLNNNGFNIELFKNFTIRSVILLDLNILLFLIIVIAFEKKINIDEEVNTQLNTRIRPLYLVNIFFIAYILVCIFLLKDIDVILSSFIMEIIYIGIIILSKKIITLELTNRQLQWQKACGYIDEDCEESSFLWRFKLWWSPHVNVPFKNRWKGPSRLLYDLALVYGIIISKGNLFSLILLILLLPDVISWLEGLLGLQTSLTGICTGITEHHSKNSHVLYHKVYVTDYKNKREITFYVDGPLFIHENSHMTVVHGTFSKRVLYVEGLNLDIR
>NZ_CP013246.1|WP_003358280.1|739393_740716_+|APC-family-permease
MLEKKYGLWTTVSMVIGIVIGSGVFFKADNILMASGGNVKTALLAWLVGAISMIFGALVFAECANRFERSNGIVDYAEGMLSEKFAYLIGWFNGIIYYPAIAAVLAWAAGNYTAILFNKDGNFVWIMAAIYMIGIYILNYISPILSGKFQIASTAIKLVPLMIIAILGIFQGLNNGILIENFSKVSIISDSGSGFAAAVLGAAFAYEGWIIATTINGEIKDAKNTLPKALVFGSLVIVIIYILYFLGIVGMIPTETILKQGDNTVNVAARTVFGNFGASILTIFIIVSCLGTLNGLILGGSRSFYSLAIRGQGIKPEAFSKLNSKTNIPTNSTIANFILICIYLVVWYMNFKGLFPNKLFIDISELPIALIYGIYIIIYIAYMMKMKDLSFIKRFVIPSLALMGALIVVYGGLSKTSVIIDLGISVFVFLSGLLFYNKKK
>NZ_CP013246.1|WP_025775915.1|740783_741518_-|protein-kinase-family-protein
MVIKFFKRDTKYLPEQKIHEYTVLKVLGEGRFGICYLVQSNNKQYILKQLKTKMLKKIGSKVIYEQEILKNINHNCIPKFVKTLQFERFFGYVLEYKEGKTFEEIICEDEYVFKREEIYDICIQIIEILKYLHKSGIVHRDIRIPNTIYYKKKVNLVDFGLARWINNKRYTENVDFSYLGDFLLHLYYTSFQCKTFKGKPWYEELDLFSEEMNFLKRLLGIEKKYKNIEEVERDFLLLKSNYNK
>NZ_CP013246.1|WP_003358486.1|742020_742794_-|2-hydroxyglutaryl-CoA-dehydratase
MYTMGLDIGSTTSKGVIIKDGKEIVASVLVPVGTGTSGPLKLIKELKEKSNLTEKDIEKTVVTGYGRIQYKDADKQISELSCHAKGVAFLIPGARTIIDIGGQDAKAMKLNDKGKLINFIMNDKCAAGTGRFLDVMAGVLETDVSKLGEISEKSTKEVSISSTCTVFAESEVISHLSANAKKEDIVAGIHTSVVRRVSTLAMRVGIEDQVVMVGGVARNKGIVKAMEKELGHDIKVPELAQLTGALGAAIYAFEETK
>NZ_CP013246.1|WP_071647345.1|742931_744218_-|hypothetical-protein
MSENSKSKVGFLTAFQVAAVWFGAHVGGGFATGNQTMNFFVKYGWHSIWLPAVIIIIIGLTYRESLVLAKNYGTYDYKSWSKKMYEPYDKFFSVIFEIGYLMIVLLGTGGSIAGSASLMETYGVSYLVGVLITGGIFYILTIYGSELIRKASTIITVLILIFLTIIVIVGIVNNSGNLSHLVSTKYSPSSFGTVLYSGLRYAGYQAFVVAIVLSASDTLKSDKAINKSILLGIILNGVMITLSCIMLLAWMPGAQKETIPILYICKRLNSGFLLFSYSVVLFLAFVSTGIGCVFGAVARFEHVFKKPENIKKRRGLISFVCMVLSMAISLFGLTKIVVIGYGYVGIIGIFAVVIPCIVVGRIKNNKFKKEQKENHITKEDQDNISKKDEENGPVEGQDDASKGNKKSVPVEGQDDMPKEDKESASIEE
>NZ_CP013246.1|WP_014521061.1|744511_745561_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MDIKKDLSSYKNVWVIAEQRQGKITPVVIELLGEGRKIANDIGVELCAVLLGYNVDNLADELIKFGADKVYYANDPLLEKYTTDGYAKVIVDAVNDIKPEIVLIGATHIGRDLAPRIASNLDTGLTADCTKLEVDPEDKKLKQTRPAFGGNIMATIICPDNRPQMSTVRPGVMDKAVKDESRKGQILELSADLIKDDIRTEVIEIVKSKKELVSLTDANFIVSGGLGLGNPDGFKLLKQLADRLGGVVGSSRAAVDAGWIENSHQVGQTGTTVKPTVYIACGISGAIQHLAGMQESDIIIAINKNESAPIFEVADYGIVGDLYDVVPKLLELLDDDDRINRLFEESKIV
>NZ_CP013246.1|WP_012100172.1|745579_746365_-|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MRIIVCVKQVPDTTEVKIDPKTGTLIREGVPSILNPDDANALEEALKMKDKDENVTVSVVSMGPPQADVMLRECLAMGADEAYLVSDRAFAGSDTWATSKVIASAIRKIGNYDIIFAGRQAIDGDTAQVGPQISEKLGIPQVTYVQDFRMEDDKITVQRQLEDGYEIIRVKKPALLTAVSSLNEPRYMAVDKIFDAYKKEIKVLTIDDLDIEKEGVGLKASPTKVFRSFTPAPKGKGVMLEGSTEEMVEKLVVSLKQKHII

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Crispr_ID: NZ_CP013246_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP013246_4

3472574-3472868

Orphan

III-B

Consensus_repeat	Method
ATTTAAATACATCTCATGTTAATGTTCAAT	PILER-CR
ATTGAACATTAACATGAGATGTATTTAAAT	CRISPRCasFinder
ATTGAACATTAACATGAGATGTATTTAAAT	CRT

4 spacers

The CRISPR arrays of NZ_CP013246_4

>merge|NZ_CP013246|4|3472574-3472868|PILER-CR,CRISPRCasFinder,CRT
ATTGAACATTAACATGAGATGTATTTAAATTTGTAATAATATACTAATACAGTTAAAGTGCAAGAAATTGAACATTAACATGAGATGTATTTAAATAAATCCTAATAGAAATGTAGAAGCTAGTACAAGAGAATTGAACATTAACATGAGATGTATTTAAATTATTGTACTTTATGATTTAAAACCTGACTTTTATCTATTGAACATTAACATGAGATGTATTTAAATATATGTGTTAAACATTTTGCCAAACATAGGTGATTTGATTGAACATTAACATGAGATGTATTTAAAT

>NZ_CP013246|4|3|3472574-3472868|PILER-CR
ATTGAACATTAACATGAGATGTATTTAAAT	TTGTAATAATATACTAATACAGTTAAAGTGCAAGAA
ATTGAACATTAACATGAGATGTATTTAAAT	AAATCCTAATAGAAATGTAGAAGCTAGTACAAGAGA
ATTGAACATTAACATGAGATGTATTTAAAT	TATTGTACTTTATGATTTAAAACCTGACTTTTATCT
ATTGAACATTAACATGAGATGTATTTAAAT	ATATGTGTTAAACATTTTGCCAAACATAGGTGATTTG
ATTGAACATTAACATGAGATGTATTTAAAT

>NZ_CP013246|4|3|3472574-3472868|CRISPRCasFinder
ATTGAACATTAACATGAGATGTATTTAAAT	TTGTAATAATATACTAATACAGTTAAAGTGCAAGAA
ATTGAACATTAACATGAGATGTATTTAAAT	AAATCCTAATAGAAATGTAGAAGCTAGTACAAGAGA
ATTGAACATTAACATGAGATGTATTTAAAT	TATTGTACTTTATGATTTAAAACCTGACTTTTATCT
ATTGAACATTAACATGAGATGTATTTAAAT	ATATGTGTTAAACATTTTGCCAAACATAGGTGATTTG
ATTGAACATTAACATGAGATGTATTTAAAT

>NZ_CP013246|4|4|3472574-3472868|CRT
ATTGAACATTAACATGAGATGTATTTAAAT	TTGTAATAATATACTAATACAGTTAAAGTGCAAGAA
ATTGAACATTAACATGAGATGTATTTAAAT	AAATCCTAATAGAAATGTAGAAGCTAGTACAAGAGA
ATTGAACATTAACATGAGATGTATTTAAAT	TATTGTACTTTATGATTTAAAACCTGACTTTTATCT
ATTGAACATTAACATGAGATGTATTTAAAT	ATATGTGTTAAACATTTTGCCAAACATAGGTGATTTG
ATTGAACATTAACATGAGATGTATTTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP013246.1\|WP_072587406.1\|3464776_3465808_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP013246.1\|WP_012704693.1\|3475932_3476904_+\|cobalamin-biosynthesis-protein	unknown	unknown	gnl\|CDD\|234919
NZ_CP013246.1\|WP_071647842.1\|3471795_3472353_+\|bifunctional-adenosylcobinamide-kinase/adenosylcobinamide-phosphate-guanylyltransferase	unknown	unknown	gnl\|CDD\|235612
NZ_CP013246.1\|WP_003357092.1\|3459617_3461225_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379716
NZ_CP013246.1\|WP_071647841.1\|3468256_3468904_+\|cyclase-family-protein	unknown	unknown	gnl\|CDD\|224790
NZ_CP013246.1\|WP_071647844.1\|3477288_3478377_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|180542
NZ_CP013246.1\|WP_071647843.1\|3472980_3473745_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_CP013246.1\|WP_011948592.1\|3464108_3464780_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP013246.1\|WP_071647845.1\|3479284_3479584_+\|energy-coupling-factor-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|179494
NZ_CP013246.1\|WP_011948604.1\|3478561_3479281_+\|energy-coupling-factor-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|181384
NZ_CP013246.1\|WP_045882391.1\|3466217_3467243_+\|branched-chain-amino-acid-aminotransferase	unknown	unknown	gnl\|CDD\|237363
NZ_CP013246.1\|WP_003357233.1\|3469908_3471504_+\|LexA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224885
NZ_CP013246.1\|WP_012703680.1\|3481209_3482082_+\|hydroxymethylbilane-synthase	unknown	unknown	gnl\|CDD\|234612
NZ_CP013246.1\|WP_101528065.1\|3472361_3472484_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP013246.1\|WP_071647840.1\|3467482_3468028_+\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|224187
NZ_CP013246.1\|WP_078983291.1\|3479546_3480245_+\|cobalt-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274139
NZ_CP013246.1\|WP_012704511.1\|3482217_3483678_+\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|273643
NZ_CP013246.1\|WP_012703986.1\|3474449_3475931_+\|cobyric-acid-synthase	unknown	unknown	gnl\|CDD\|234838
NZ_CP013246.1\|WP_053337864.1\|3461588_3463949_-\|ABC-transporter-ATP-binding-protein/permease	unknown	unknown	gnl\|CDD\|213222
NZ_CP013246.1\|WP_071647846.1\|3480578_3481241_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235504

Protein	Function_ID	Function_description	E-value
NZ_CP013246.1\|WP_072587406.1\|3464776_3465808_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.18177e-59
NZ_CP013246.1\|WP_012704693.1\|3475932_3476904_+\|cobalamin-biosynthesis-protein	gnl\|CDD\|234919	PRK01209, cobD, cobalamin biosynthesis protein.	2.90574e-151
NZ_CP013246.1\|WP_071647842.1\|3471795_3472353_+\|bifunctional-adenosylcobinamide-kinase/adenosylcobinamide-phosphate-guanylyltransferase	gnl\|CDD\|235612	PRK05800, cobU, adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Validated.	7.74076e-84
NZ_CP013246.1\|WP_003357092.1\|3459617_3461225_+\|hypothetical-protein	gnl\|CDD\|379716	pfam14897, EpsG, EpsG family. This family of proteins are related to the EpsG protein from B. subtilis. These proteins are likely glycosyl transferases belonging to the membrane protein GT-C clan.	0.000680106
NZ_CP013246.1\|WP_071647841.1\|3468256_3468904_+\|cyclase-family-protein	gnl\|CDD\|224790	COG1878, COG1878, Kynurenine formamidase [Amino acid transport and metabolism].	3.11238e-66
NZ_CP013246.1\|WP_071647844.1\|3477288_3478377_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|180542	PRK06358, PRK06358, threonine-phosphate decarboxylase; Provisional.	3.76198e-90
NZ_CP013246.1\|WP_071647843.1\|3472980_3473745_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	1.09172e-48
NZ_CP013246.1\|WP_011948592.1\|3464108_3464780_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.46155e-65
NZ_CP013246.1\|WP_071647845.1\|3479284_3479584_+\|energy-coupling-factor-ABC-transporter-substrate-binding-protein	gnl\|CDD\|179494	PRK02898, PRK02898, energy-coupling factor ABC transporter substrate-binding protein.	5.03816e-42
NZ_CP013246.1\|WP_011948604.1\|3478561_3479281_+\|energy-coupling-factor-ABC-transporter-permease	gnl\|CDD\|181384	PRK08319, PRK08319, energy-coupling factor ABC transporter permease.	2.23594e-119
NZ_CP013246.1\|WP_045882391.1\|3466217_3467243_+\|branched-chain-amino-acid-aminotransferase	gnl\|CDD\|237363	PRK13357, PRK13357, branched-chain amino acid aminotransferase; Provisional.	0
NZ_CP013246.1\|WP_003357233.1\|3469908_3471504_+\|LexA-family-transcriptional-regulator	gnl\|CDD\|224885	COG1974, LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms].	3.33637e-33
NZ_CP013246.1\|WP_012703680.1\|3481209_3482082_+\|hydroxymethylbilane-synthase	gnl\|CDD\|234612	PRK00072, hemC, porphobilinogen deaminase; Reviewed.	2.10113e-147
NZ_CP013246.1\|WP_012703986.1\|3474449_3475931_+\|cobyric-acid-synthase	gnl\|CDD\|234838	PRK00784, PRK00784, cobyric acid synthase.	0
NZ_CP013246.1\|WP_078983291.1\|3479546_3480245_+\|cobalt-ABC-transporter-permease	gnl\|CDD\|274139	TIGR02454, Uncharacterized_protein_MJ1089, cobalt ECF transporter T component CbiQ. This model represents the CbiQ component of the cobalt-specific ECF-type. CbiQ is now recognized as the T component of energy-coupling factor (ECF)-type transporters. The S component confers specificity (CbiM-N for cobalt systems), which CbiO is the ABC-family ATPase. In general, proteins found by this model reside next to the other putative subunits of the complex, identified as CbiN, CbiO, or CbiM. Note that the designation of cobalt transporter has been spread excessively among ECF system transporters with many other specificities. [Transport and binding proteins, Cations and iron carrying compounds].	7.07741e-28
NZ_CP013246.1\|WP_012704511.1\|3482217_3483678_+\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|273643	TIGR01469, Uroporphyrinogen-III_C-methyltransferase, uroporphyrin-III C-methyltransferase. This model represents enzymes, or enzyme domains, with uroporphyrin-III C-methyltransferase activity. This enzyme catalyzes the first step committed to the biosynthesis of either siroheme or cobalamin (vitamin B12) rather than protoheme (heme). Cobalamin contains cobalt while siroheme contains iron. Siroheme is a cofactor for nitrite and sulfite reductases and therefore plays a role in cysteine biosynthesis; many members of this family are CysG, siroheme synthase, with an additional N-terminal domain and with additional oxidation and iron insertion activities. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	1.14257e-119
NZ_CP013246.1\|WP_071647840.1\|3467482_3468028_+\|biotin-transporter-BioY	gnl\|CDD\|224187	COG1268, BioY, Uncharacterized conserved protein [General function prediction only].	3.67404e-40
NZ_CP013246.1\|WP_053337864.1\|3461588_3463949_-\|ABC-transporter-ATP-binding-protein/permease	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.54183e-112
NZ_CP013246.1\|WP_071647846.1\|3480578_3481241_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235504	PRK05562, PRK05562, NAD(P)-dependent oxidoreductase.	2.36813e-106

>NZ_CP013246.1|WP_101528065.1|3472361_3472484_-|hypothetical-protein
MFYKGRDKTYLKAYISIPRIDFKIKCGWKILLLIVRLISY
>NZ_CP013246.1|WP_071647842.1|3471795_3472353_+|bifunctional-adenosylcobinamide-kinase/adenosylcobinamide-phosphate-guanylyltransferase
MSDKNKVVLITGGVRSGKSEFAEGLLQNEKSVLYIATAKITDKEMEHRVEKHKERRNGTWKTYEGYKDLGKIMKYYDEKNILLDCITVMTTNLMFHKEIDYENIKEGELDEILEGIKKEFYDLIISVKEENKNIILVTNEVGYSIVPAYKLGRIFRDFQGIINKFIASLSDEVYLVTCGIPLKIK
>NZ_CP013246.1|WP_003357233.1|3469908_3471504_+|LexA-family-transcriptional-regulator
MKLESGQNRIVKSKHLGYGLLRGSLGTGKTTAAIYRGIYLKNQYCMYDKDKVLILSKNEENSNYIKNIYDEAEKTGVQYITLFSYIEDKLYFSVIYKIINKYFWEYIENNNLQCKIASEEEKLAIIEECINDIKNEYKKLKYIDIKYSKFFLEEIQWMKDCMYYELEEYKKADRIGRKTKKGEGPQRIIKNSKIREAVFKIMLLYNEKLKDKNLVDYSDVVFMSLKEACKNKENKFNHIIVDEAQNFTKLELKFIEALGRKNIYSSILFIADKEKNSNPKGWITKGRKLNNLQLGFEFKRFNLNKKISINLKENIDDCDLKRKVSNIDTKNEDVSNIDNANSEDKVLDKNIKNEWHKAKVNYNMDKFEYVDIKHRRSYEFFRDLGSNEEIIVEDQGSKEEYKENELTKLPVFNDIAAGEPILMNPCVEGEFNIPKYWVRGMKDCFILKVKGDSMIGANIEDGDHVVIKRQQMAENKDIVAVNLEGNATLKRLLIKKSGAVLMPENKKYKPIEIREEGANIIGIAVGIIKGK
>NZ_CP013246.1|WP_071647841.1|3468256_3468904_+|cyclase-family-protein
MKVIDLTHTISENMPVYPGTERPKLEVKSTYDKDGFKETLLTMFSHIGTHMDSPAHLFLERTNLDSFSPEQFVGKGLVIDCSDLKEGEKIHMKYIDCVKEKANKADFILFHTGWDRYWGTDFYFGDYPYITEEVAEYLIYNKKKGVGVDVIGIDPISDENLTIHRKLFLKTDIVVIENLTRLGEVGNELFTFCALPIKYENSDGAPIRAIAILQD
>NZ_CP013246.1|WP_071647840.1|3467482_3468028_+|biotin-transporter-BioY
MAKKLEVRDMIYSALFATIIGVSSYITIPLPISPVPITAQSLSVMLAGCVLTPIQVVLSMITFLLMGVIGIPVFSGGRAGIGIIVGKTGGYLIGFLIGAIIISILVRKNKSLFNMLIACFVGGIVVVHILGSAWLGQVTSIGIKKAFLLGSAPFIPGDLIKAVVAVLIGRKLSKQIKKSTI
>NZ_CP013246.1|WP_045882391.1|3466217_3467243_+|branched-chain-amino-acid-aminotransferase
MNKEVNIDWGNLGFNYINTDLRYTSRWKDGKWDEGQLVEDNMISINESSTALHYGQQCFEGLKAYRTKDNKIQLFRPDRNAERMQDSCKRILMPEVPTEKFIDACIKVVKANERYVPPYGSGATLYLRPFVIGVGDNIGVKPAAEYIFSIFCIPVGPYFKGGMVPVNFTVSDYDRAAPYGTGAVKVGGNYAGSLYPHELAVKKGFADCIYLDPATHTKIEEVGAANFFGITKDNKFITPKSPSILPSITKYSLLHIAKEYLKMEVEERDVLIDNLDEFKEAGACGTAAVITPIGGIEYKGKLHVFHSETEVGPITKKLYDTLYGIQFGEVEAPQGWIVEVK
>NZ_CP013246.1|WP_072587406.1|3464776_3465808_+|HAMP-domain-containing-histidine-kinase
MMNNKISVKMVVAFSLIVFFIVTSAVVISGLVVVFLSRFNVFTQPNPLILLGWLGIISIMVSTAIAQIIGKKVLSPISDLNKATKEVAKGNFNTRLSESSWTDEIREMAHSFNIMTHELGNIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEERREYIHKILISTKRLSSLSGNILQITELENQKILPLEQKYYLDEQIRQTILLFEYQWTKKNITLDINLDNITYIGSKELLAQVWQNILGNAIKFSHQNGTIQVTLTQTNEEVLITIKDNGIGMSEEVKNRVFEKFYQGDSSHYSDGNGLGLALVKRIIDICEGTIEISSHEGVGTDFIVKLPK
>NZ_CP013246.1|WP_011948592.1|3464108_3464780_+|response-regulator-transcription-factor
MFKVLVVEDDPALRKLFCTVLNKNGYKSIEAKDGHSALDVLYKEYIDLIISDIMMPNMDGYTLTKLIRESNNNVPILMITAKETFSDKQEGFRVGTDDYMVKPIDVNEMILRVGALLRRSQIINERRIVIGETTFLYDFLSVKYNNKELVLPQKEFYLIYKLVSTPNKIFTRQQLMDEIWGIESETDPRTVDVHINRLRDRFKDNKDFNIITIRGLGYKVVKQ
>NZ_CP013246.1|WP_053337864.1|3461588_3463949_-|ABC-transporter-ATP-binding-protein/permease
MLQIKDLKKVYTTGEFKQTALDGVSIDFRQSEFVAILGPSGSGKTTLLNMLGGLDQYDSGDMIINGLSTKKFGESDWDTYRNNSVGFIFQSYNLIPHLSIIDNVEMGMTLSGVPKSEKRQKATYVLEKVGLGNHIHKKPNQLSGGQMQRVAIARALANDPEIILADEPTGALDTQTSEQIMDLIKEIAKDKLVIMVTHNPELAEEYADRIVSFSDGKIVSDTNPFVSENNSNDYKPKKTSMNFLTALKLSGNNIVTKKWRTALTAFASSIGIIGVALVLSLSNGFNKQINEFEKDSLSNYPISIEQNSMSLGMSPSSKSKDKEKTEFPNESMIYPYDSSENAAVHANAISTEYVDYIKKIDSSLINGISYTRNVNMNILKKQDGKVVSMNTSAAAFSTYPSKGDSFETDYLKSYYDVLAGSYPKNEKELVLVVDKYNQVDTSILEALGFSADSKNINFDSMIGTEYKLIYNDDYYTQSGKYFTVNGDTTNLENLYNNKSAVTLKISGIIRIKEDANVSNLSTGIVYSDQLAQDFIENAKNSKIVLAQKEAKYNVMNGNLLTEKTSTTTAAVHPTPNMTTNITPNIETKDDVLASLGATSSPTSISIYPVNFEAKDNITNYLDDWNKKLKEEDQIVYTDMASMITSLTGNIMDGITIVLVAFAGISLVVSMIMIGIIIYISVLERTKEIGVLRALGARKKDITRVFNAETFIIGFCSGGLGIAITYLLTIPVNSILYKFTDLNNVAQLNPLHAIALVITSIVLTMIGGAIPSKMAAKKDPVIALRSE
>NZ_CP013246.1|WP_003357092.1|3459617_3461225_+|hypothetical-protein
MKKKIYSSFIVLSLIISMALIYFLMPVFSVKFYSFYIVFIIIALLLSINVSLNKGKESSKIYAIPVILIGLFIIMFIISLPIFRASSYKNLLPAPKYEEFSKNITPIDIKEIPTVNQKYAELLADKKLGEETSLGSKVELGTLTLQNVNGKLYYVAPLVHSGFMKWLLNDSTPGYITVSATDDKDVKLVTKLNGKDIKIRYQPKGFLNDDLKRHIYLKGTMNRGITDLTFELDDKGNPYYTATIYENKVGMSGQKAVGTAIVNPETGEVKKYTVENTPKWVDRIQPQSFVENNLKKWGKYIKGFFNFSGQDKLKTTEGTGVIYNNGKCYYYTGLTSAGKDESSIGFALVDTRTQQTRIFKIAGATETASMKSAEGKVQNLGYTSTFPILINVDNVPTYFTTLNDKNDLTKMFAMISVTDYNIIGTGENITECKSNYIKNLASKGNLINVGSTGKEEIITDTIERINSYVVGNSTIYTFVLKDHKDKIFNAGISISNELPITKEGDKVNIRYVDTKQDTINITSFDNIEFKQQSIK
>NZ_CP013246.1|WP_071647843.1|3472980_3473745_-|MerR-family-transcriptional-regulator
MHYKIKEVADMAGISVRMLHHYDKIGLLDPESVSAAGYRLYSDENLDRLQQILFFKELNFPLQEIKIILDSPNFNKKEALETHRQLLLEKKLRLEKIIQSVDKTINSMEGEFKMDKKEILNVFSMTEIEEHQRKYSEDVKEKYGNTSAYKESNEKTSKYTKEDWSNIMKDWDIIYKKLANLMDKNPDDKEVQECIHQSREHISKNFYDCTPEIFRGLGEIYVNDERFTANIDKYKTGLSKFLRDAINVYCDNIK
>NZ_CP013246.1|WP_012703986.1|3474449_3475931_+|cobyric-acid-synthase
MAKIMIQGTASSVGKSLIVAALCRIFKQDGYSVCPFKSQNMSLNSYITLDGKEMGRAQVLQAYAAGLEPEVYMNPILLKPTSDKKCQIIVNGKVYGNSTAMGYHNLKLKFKNMLKGHFNKLEEDFDIVVMEGAGSPAEINLRDRDIVNMGMAELVDAPVLLVGDIDKGGVFASLAGTMLLLNEGEKKRVKGTIINKFRGDVEILKPGLDMLEDIIHIPCLGVVPYTRLQLEDEDGAVEFNKKAYAPIDIAVIKMPHISNFTDLDALKSEEDVSIRFITSKEEFKEPDLLVIPGSKNTIEDLLYLRKCGLEESIKEYSKDGKIIGICGGYQVLGSKIKDPHNVETDLGEIDGLNLLDMETTFEKEKVTTRVSAKLLNEETKNTVYGYEIHMGISKYGENIKPLFKIYDKNGEKVDYFDGAINEKGNVMGTYIHGVFDGVVFREKIINELRVKKGLKKKKSQMYEHMREKELDKLADIVRHSLDMEKIYSIIGMK
>NZ_CP013246.1|WP_012704693.1|3475932_3476904_+|cobalamin-biosynthesis-protein
MYLNITTNFIDIIIAVFIDWIIGDPYWFPHPVIYIGKLISFLEKKFRTKVKNEENLKIYGGIIVLIVCLASFLIPFMLLQAFKFNFYLYHGLNILIIWTTLAAKCLHGEAIKIYHALYKENIEEARLKLSYIVGRETKDLIGNEIMRADIETVAENASDGVIAPLFYAIIGGAPLAMMYKGINTMDSMLGYLNDEYRYIGFFPAKVDDIFNFVPARLTGILMCISAPLVGGNPFKSFKIMIRDRKNHKSPNCAYPEGATAAALKIQLGGTNVYFGQVVEKPTIGDKIKELAPIHIKESIKLMYASEALMIVMVGVLLKLLFEI
>NZ_CP013246.1|WP_071647844.1|3477288_3478377_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLEEALSWVQVYPDIQYRNLKRNLIDYLSFSLDYFYKEKVDKLNIKEENLVLGNGAVEIIDLAISNLKSISILVPSFVEYELCAKKWNVQIDYCNLNEDMTYNYEIIKKSLEKTEGIILGNPNNPNGSVIDKEEFIYILDYCEKNNKIVILDEAFIEFTGKDSLSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNKFLNKIRKKQNPWNINCFAEIAVKYVLKDKDFIEKSISYIEKERTFMYENLKKCYLFHEVYSTYSNFILCKIKRITGEELKEKLLDKGFVLRVCKDFKTLNNNYVRFAIKTRELNEDLLHLLKEIN
>NZ_CP013246.1|WP_011948604.1|3478561_3479281_+|energy-coupling-factor-ABC-transporter-permease
MKKKYLFLLTTALVLALSQSAYAMHIAEGFLPPKWAALYFVLSAPFIVIGVKHIRQKTKKNKDLKMLLAVVAAYAFILSAMKIPSVTGSCSHPTGTGLAAIIFGPFVASVVGVIVLLFQAILLAHGGITTLGANTFSMGIVGPIVSYLIYKGLKNKNQKLAVFLAASLGDLATYTVTSLQLALSFPAKTGGVMAAFAKFATIFSLTQIPLAIIEGLITIMIFEFMMKYSKEELKTLSEV
>NZ_CP013246.1|WP_071647845.1|3479284_3479584_+|energy-coupling-factor-ABC-transporter-substrate-binding-protein
MKKQNIIIIIVSVVVILASLFIGGARGGEFAGADDQAEGIIEEMNKDYEPWFESIWEPPSGEIESLLFASQAALGAGVIGYYIGKKKNAKNNNASIKNQ
>NZ_CP013246.1|WP_078983291.1|3479546_3480245_+|cobalt-ABC-transporter-permease
MLRTIMLLSKTSKLSNIHPLEKAILSIIPIVILGFTQNYIIVFCNILFFLFMNFISKNNKKIFTKITLEVTAFAAISSITFVLDYGIAYTLTLILKSLSAGLCLSFFSLTTPIDDMLYCLGKKEYLKDMCDIAKGMERFLVVINDEYNILYSSIKSRGGFDTFKLTIRNTGKMAALLFINTLSRWKIIKEGLDSRGYVGYMPYLDRNFDFSYIRFLSILSYIILILLLVIFF
>NZ_CP013246.1|WP_071647846.1|3480578_3481241_+|NAD(P)-dependent-oxidoreductase
MEWINLQEKYNFIALKSRRIRILIVGGGRAAFIKGKAFLDRGCSLYILAPKFSKGVLDLKTYDNVEFIKNNYDEKYILDKHLVVIATEDEEVNNEIRNNCDSLSKLYIDCSDKDKSLCFNSFQRESKTMVLALNNKIGCPKATSFIGEKIKKDLERYDNYIEYVTYIRSITKNNSMKDEIIDFICSNDFHFFFEKGYGNLILSMFYGGMDFEFCNSHTKK
>NZ_CP013246.1|WP_012703680.1|3481209_3482082_+|hydroxymethylbilane-synthase
MNFVIATRRSKLAQVQTEIIIDLLNKKHDIECEKLLIETVGDKILEVSLDKIGGKGLFVKDIEVAMLEQRADAAVHSMKDVPYEMPKGFEIIAIPEREDVRDAFISLDNIKFKDLRKGAKIGTSSRRRAAQLKLLRPDLDIVPIRGNVQTRIEKIKKENLDGIILAVAGLKRVNLDHLITDYFDTKEMVPAIGQGALGIEVMEEHPKKELFKDLDHYNSKICVLAERAFMRELDGDCHSTIGAYASIKDNIMHIIGIFERKNKIIKKEITGTKDQYEKLGISLAEHILKD
>NZ_CP013246.1|WP_012704511.1|3482217_3483678_+|uroporphyrinogen-III-C-methyltransferase
MSKVYLIGAGPGDEELITLKAIRALKKCTAVMYDRLANGELLKYLAPNCEIYYCGKEPGCHYKSQDEINKMLVKLAKEGHIVGRIKGGDPYVFGRGGEEALDILEENIEFEVIPGVTSPVSVLNYAGIPITHRGISRGFHIFTAMTKDKLDIDWKSVVNIGGTLVFLMGLGRLELITKGLIENGMDKEGKVAVVMKGTTSKQKKVIGNLENIVEKVKEAKLESPVIIVVGEVVSFSDKLNWYEKKPLFGRNICITRTKEQAKELKVQLLDLGAEVTEINSIEIKNAEENLKPYLNRLKEYDYIALTSVNAVKIFFDYLIKENIDIRNINAKFAAIGPATSEAIKVRGIMPSIKSKHFVAESLFEEMKKHVQSGDKVLVPRSKDARPFLVDALKKEGCIVDEVHIYETLCGQSSHTERFEDADTVLFTSPSTVKNMISMVGIDSIKEKSIIAIGPITAAELYKNNIECSICDEYSINGIIDKLLDLN

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP013246_2	2.4\|698412\|36\|NZ_CP013246\|PILER-CR	698412-698447	36	NZ_CP014152	Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence	200274-200309	0	1.0
NZ_CP013246_2	2.4\|698412\|36\|NZ_CP013246\|PILER-CR	698412-698447	36	NZ_CP006909	Clostridium botulinum CDC_1436 plasmid pCBG, complete sequence	26889-26924	0	1.0
NZ_CP013246_2	2.4\|698412\|36\|NZ_CP013246\|PILER-CR	698412-698447	36	NZ_CP031095	Clostridium botulinum strain CFSAN034200 plasmid p1_CDC51232, complete sequence	171721-171756	0	1.0
NZ_CP013246_2	2.4\|698412\|36\|NZ_CP013246\|PILER-CR	698412-698447	36	NZ_CP013710	Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence	79076-79111	0	1.0
NZ_CP013246_2	2.4\|698412\|36\|NZ_CP013246\|PILER-CR	698412-698447	36	NC_010418	Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence	256590-256625	0	1.0
NZ_CP013246_2	2.4\|698412\|36\|NZ_CP013246\|PILER-CR	698412-698447	36	NZ_CP013700	Clostridium botulinum strain AM1195 plasmid pRSJ11_1, complete sequence	267156-267191	0	1.0
NZ_CP013246_2	2.4\|698412\|36\|NZ_CP013246\|PILER-CR	698412-698447	36	NC_012654	Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence	210427-210462	0	1.0
NZ_CP013246_3	3.4\|735142\|36\|NZ_CP013246\|PILER-CR,CRISPRCasFinder,CRT	735142-735177	36	NZ_CP013848	Clostridium botulinum strain Af650 plasmid pRSJ14_1, complete sequence	6073-6108	0	1.0
NZ_CP013246_2	2.4\|698412\|36\|NZ_CP013246\|PILER-CR	698412-698447	36	NZ_CP013684	Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence	169483-169518	1	0.972
NZ_CP013246_2	2.6\|698544\|35\|NZ_CP013246\|PILER-CR	698544-698578	35	NZ_CP013682	Clostridium botulinum strain 1169 plasmid pRSJ8_1, complete sequence	117439-117473	1	0.971
NZ_CP013246_2	2.6\|698544\|35\|NZ_CP013246\|PILER-CR	698544-698578	35	NZ_CP013295	Clostridium botulinum strain CDC_54064 plasmid pNPD1_1, complete sequence	128155-128189	1	0.971
NZ_CP013246_4	4.3\|3472736\|36\|NZ_CP013246\|PILER-CR,CRISPRCasFinder,CRT	3472736-3472771	36	NZ_CP013710	Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence	60830-60865	1	0.972
NZ_CP013246_4	4.3\|3472736\|36\|NZ_CP013246\|PILER-CR,CRISPRCasFinder,CRT	3472736-3472771	36	NC_010418	Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence	237573-237608	1	0.972
NZ_CP013246_4	4.3\|3472736\|36\|NZ_CP013246\|PILER-CR,CRISPRCasFinder,CRT	3472736-3472771	36	NZ_CP013700	Clostridium botulinum strain AM1195 plasmid pRSJ11_1, complete sequence	248913-248948	1	0.972
NZ_CP013246_4	4.3\|3472736\|36\|NZ_CP013246\|PILER-CR,CRISPRCasFinder,CRT	3472736-3472771	36	NC_012654	Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence	191414-191449	1	0.972
NZ_CP013246_4	4.3\|3472736\|36\|NZ_CP013246\|PILER-CR,CRISPRCasFinder,CRT	3472736-3472771	36	NZ_CP014152	Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence	218520-218555	1	0.972
NZ_CP013246_4	4.3\|3472736\|36\|NZ_CP013246\|PILER-CR,CRISPRCasFinder,CRT	3472736-3472771	36	NZ_CP006909	Clostridium botulinum CDC_1436 plasmid pCBG, complete sequence	45892-45927	1	0.972
NZ_CP013246_4	4.3\|3472736\|36\|NZ_CP013246\|PILER-CR,CRISPRCasFinder,CRT	3472736-3472771	36	NZ_CP013684	Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence	187707-187742	1	0.972
NZ_CP013246_4	4.3\|3472736\|36\|NZ_CP013246\|PILER-CR,CRISPRCasFinder,CRT	3472736-3472771	36	NZ_CP031095	Clostridium botulinum strain CFSAN034200 plasmid p1_CDC51232, complete sequence	190734-190769	1	0.972
NZ_CP013246_2	2.4\|698412\|36\|NZ_CP013246\|PILER-CR	698412-698447	36	NC_025146	Clostridium botulinum plasmid pCB111 DNA, complete sequence, strain: 111	147484-147519	2	0.944
NZ_CP013246_2	2.6\|698544\|35\|NZ_CP013246\|PILER-CR	698544-698578	35	NZ_CP013709	Clostridium botulinum strain F634 plasmid pRSJ2_2, complete sequence	117155-117189	2	0.943
NZ_CP013246_2	2.6\|698544\|35\|NZ_CP013246\|PILER-CR	698544-698578	35	NZ_CP013844	Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence	162592-162626	2	0.943
NZ_CP013246_2	2.1\|698402\|44\|NZ_CP013246\|CRT	698402-698445	44	NZ_CP014152	Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence	200265-200308	6	0.864
NZ_CP013246_2	2.1\|698402\|44\|NZ_CP013246\|CRT	698402-698445	44	NZ_CP006909	Clostridium botulinum CDC_1436 plasmid pCBG, complete sequence	26880-26923	6	0.864
NZ_CP013246_2	2.1\|698402\|44\|NZ_CP013246\|CRT	698402-698445	44	NZ_CP013710	Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence	79077-79120	6	0.864
NZ_CP013246_2	2.1\|698402\|44\|NZ_CP013246\|CRT	698402-698445	44	NC_010418	Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence	256591-256634	6	0.864
NZ_CP013246_2	2.1\|698402\|44\|NZ_CP013246\|CRT	698402-698445	44	NZ_CP013700	Clostridium botulinum strain AM1195 plasmid pRSJ11_1, complete sequence	267157-267200	6	0.864
NZ_CP013246_2	2.1\|698402\|44\|NZ_CP013246\|CRT	698402-698445	44	NC_012654	Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence	210428-210471	6	0.864
NZ_CP013246_2	2.1\|698402\|44\|NZ_CP013246\|CRT	698402-698445	44	NZ_CP031095	Clostridium botulinum strain CFSAN034200 plasmid p1_CDC51232, complete sequence	171712-171755	6	0.864
NZ_CP013246_2	2.3\|698534\|43\|NZ_CP013246\|CRT	698534-698576	43	NZ_CP013682	Clostridium botulinum strain 1169 plasmid pRSJ8_1, complete sequence	117440-117482	6	0.86
NZ_CP013246_2	2.3\|698534\|43\|NZ_CP013246\|CRT	698534-698576	43	NZ_CP013295	Clostridium botulinum strain CDC_54064 plasmid pNPD1_1, complete sequence	128156-128198	6	0.86
NZ_CP013246_2	2.1\|698402\|44\|NZ_CP013246\|CRT	698402-698445	44	NZ_CP013684	Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence	169474-169517	7	0.841
NZ_CP013246_2	2.3\|698534\|43\|NZ_CP013246\|CRT	698534-698576	43	NZ_CP013709	Clostridium botulinum strain F634 plasmid pRSJ2_2, complete sequence	117156-117198	7	0.837
NZ_CP013246_2	2.3\|698534\|43\|NZ_CP013246\|CRT	698534-698576	43	NZ_CP013844	Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence	162593-162635	7	0.837
NZ_CP013246_2	2.1\|698402\|44\|NZ_CP013246\|CRT	698402-698445	44	NC_025146	Clostridium botulinum plasmid pCB111 DNA, complete sequence, strain: 111	147475-147518	8	0.818
NZ_CP013246_2	2.6\|698544\|35\|NZ_CP013246\|PILER-CR	698544-698578	35	AP014086	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C3-MedDCM-OCT-S45-C97, * SEQUENCING IN PROGRESS *	10171-10205	9	0.743

1. spacer 2.4|698412|36|NZ_CP013246|PILER-CR matches to NZ_CP014152 (Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence) position: , mismatch: 0, identity: 1.0

tgaaatatctggaataaatctatttgacatatcacc	CRISPR spacer
tgaaatatctggaataaatctatttgacatatcacc	Protospacer
************************************

2. spacer 2.4|698412|36|NZ_CP013246|PILER-CR matches to NZ_CP006909 (Clostridium botulinum CDC_1436 plasmid pCBG, complete sequence) position: , mismatch: 0, identity: 1.0

tgaaatatctggaataaatctatttgacatatcacc	CRISPR spacer
tgaaatatctggaataaatctatttgacatatcacc	Protospacer
************************************

3. spacer 2.4|698412|36|NZ_CP013246|PILER-CR matches to NZ_CP031095 (Clostridium botulinum strain CFSAN034200 plasmid p1_CDC51232, complete sequence) position: , mismatch: 0, identity: 1.0

tgaaatatctggaataaatctatttgacatatcacc	CRISPR spacer
tgaaatatctggaataaatctatttgacatatcacc	Protospacer
************************************

4. spacer 2.4|698412|36|NZ_CP013246|PILER-CR matches to NZ_CP013710 (Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence) position: , mismatch: 0, identity: 1.0

tgaaatatctggaataaatctatttgacatatcacc	CRISPR spacer
tgaaatatctggaataaatctatttgacatatcacc	Protospacer
************************************

5. spacer 2.4|698412|36|NZ_CP013246|PILER-CR matches to NC_010418 (Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence) position: , mismatch: 0, identity: 1.0

tgaaatatctggaataaatctatttgacatatcacc	CRISPR spacer
tgaaatatctggaataaatctatttgacatatcacc	Protospacer
************************************

6. spacer 2.4|698412|36|NZ_CP013246|PILER-CR matches to NZ_CP013700 (Clostridium botulinum strain AM1195 plasmid pRSJ11_1, complete sequence) position: , mismatch: 0, identity: 1.0

tgaaatatctggaataaatctatttgacatatcacc	CRISPR spacer
tgaaatatctggaataaatctatttgacatatcacc	Protospacer
************************************

7. spacer 2.4|698412|36|NZ_CP013246|PILER-CR matches to NC_012654 (Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence) position: , mismatch: 0, identity: 1.0

tgaaatatctggaataaatctatttgacatatcacc	CRISPR spacer
tgaaatatctggaataaatctatttgacatatcacc	Protospacer
************************************

8. spacer 3.4|735142|36|NZ_CP013246|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013848 (Clostridium botulinum strain Af650 plasmid pRSJ14_1, complete sequence) position: , mismatch: 0, identity: 1.0

gaaatgttttagaaaggatatgtgagatatggagga	CRISPR spacer
gaaatgttttagaaaggatatgtgagatatggagga	Protospacer
************************************

9. spacer 2.4|698412|36|NZ_CP013246|PILER-CR matches to NZ_CP013684 (Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence) position: , mismatch: 1, identity: 0.972

tgaaatatctggaataaatctatttgacatatcacc	CRISPR spacer
tgaaatatctggaataaatctatttgatatatcacc	Protospacer
***************************.********

10. spacer 2.6|698544|35|NZ_CP013246|PILER-CR matches to NZ_CP013682 (Clostridium botulinum strain 1169 plasmid pRSJ8_1, complete sequence) position: , mismatch: 1, identity: 0.971

gcacaagctaaattagtttttaataatacacccat	CRISPR spacer
gcacaagctaaattagtttttaataatactcccat	Protospacer
***************************** *****

11. spacer 2.6|698544|35|NZ_CP013246|PILER-CR matches to NZ_CP013295 (Clostridium botulinum strain CDC_54064 plasmid pNPD1_1, complete sequence) position: , mismatch: 1, identity: 0.971

gcacaagctaaattagtttttaataatacacccat	CRISPR spacer
gcacaagctaaattagtttttaataatactcccat	Protospacer
***************************** *****

12. spacer 4.3|3472736|36|NZ_CP013246|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013710 (Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence) position: , mismatch: 1, identity: 0.972

tattgtactttatgatttaaaacctgacttttatct	CRISPR spacer
tattgtactttatgatttaaaacttgacttttatct	Protospacer
***********************.************

13. spacer 4.3|3472736|36|NZ_CP013246|PILER-CR,CRISPRCasFinder,CRT matches to NC_010418 (Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence) position: , mismatch: 1, identity: 0.972

tattgtactttatgatttaaaacctgacttttatct	CRISPR spacer
tattgtactttatgatttaaaacttgacttttatct	Protospacer
***********************.************

14. spacer 4.3|3472736|36|NZ_CP013246|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013700 (Clostridium botulinum strain AM1195 plasmid pRSJ11_1, complete sequence) position: , mismatch: 1, identity: 0.972

tattgtactttatgatttaaaacctgacttttatct	CRISPR spacer
tattgtactttatgatttaaaacttgacttttatct	Protospacer
***********************.************

15. spacer 4.3|3472736|36|NZ_CP013246|PILER-CR,CRISPRCasFinder,CRT matches to NC_012654 (Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence) position: , mismatch: 1, identity: 0.972

tattgtactttatgatttaaaacctgacttttatct	CRISPR spacer
tattgtactttatgatttaaaacttgacttttatct	Protospacer
***********************.************

16. spacer 4.3|3472736|36|NZ_CP013246|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014152 (Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence) position: , mismatch: 1, identity: 0.972

tattgtactttatgatttaaaacctgacttttatct	CRISPR spacer
tattgtactttatgatttaaaacttgacttttatct	Protospacer
***********************.************

17. spacer 4.3|3472736|36|NZ_CP013246|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006909 (Clostridium botulinum CDC_1436 plasmid pCBG, complete sequence) position: , mismatch: 1, identity: 0.972

tattgtactttatgatttaaaacctgacttttatct	CRISPR spacer
tattgtactttatgatttaaaacttgacttttatct	Protospacer
***********************.************

18. spacer 4.3|3472736|36|NZ_CP013246|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013684 (Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence) position: , mismatch: 1, identity: 0.972

tattgtactttatgatttaaaacctgacttttatct	CRISPR spacer
tattgtactttatgatttaaaacttgacttttatct	Protospacer
***********************.************

19. spacer 4.3|3472736|36|NZ_CP013246|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031095 (Clostridium botulinum strain CFSAN034200 plasmid p1_CDC51232, complete sequence) position: , mismatch: 1, identity: 0.972

tattgtactttatgatttaaaacctgacttttatct	CRISPR spacer
tattgtactttatgatttaaaacttgacttttatct	Protospacer
***********************.************

20. spacer 2.4|698412|36|NZ_CP013246|PILER-CR matches to NC_025146 (Clostridium botulinum plasmid pCB111 DNA, complete sequence, strain: 111) position: , mismatch: 2, identity: 0.944

tgaaatatctggaataaatctatttgacatatcacc	CRISPR spacer
tgaagtgtctggaataaatctatttgacatatcacc	Protospacer
****.*.*****************************

21. spacer 2.6|698544|35|NZ_CP013246|PILER-CR matches to NZ_CP013709 (Clostridium botulinum strain F634 plasmid pRSJ2_2, complete sequence) position: , mismatch: 2, identity: 0.943

gcacaagctaaattagtttttaataatacacccat	CRISPR spacer
gcacaagcgaaattagtttttaataacacacccat	Protospacer
******** *****************.********

22. spacer 2.6|698544|35|NZ_CP013246|PILER-CR matches to NZ_CP013844 (Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence) position: , mismatch: 2, identity: 0.943

gcacaagctaaattagtttttaataatacacccat	CRISPR spacer
gcacaagcgaaattagtttttaataacacacccat	Protospacer
******** *****************.********

23. spacer 2.1|698402|44|NZ_CP013246|CRT matches to NZ_CP014152 (Clostridium botulinum strain BrDura plasmid pRSJ20_1, complete sequence) position: , mismatch: 6, identity: 0.864

ttgttcaactgaaatatctggaataaatctatttgacatatcac	CRISPR spacer
tacagcaggtgaaatatctggaataaatctatttgacatatcac	Protospacer
*    **. ***********************************

24. spacer 2.1|698402|44|NZ_CP013246|CRT matches to NZ_CP006909 (Clostridium botulinum CDC_1436 plasmid pCBG, complete sequence) position: , mismatch: 6, identity: 0.864

ttgttcaactgaaatatctggaataaatctatttgacatatcac	CRISPR spacer
tacagcaggtgaaatatctggaataaatctatttgacatatcac	Protospacer
*    **. ***********************************

25. spacer 2.1|698402|44|NZ_CP013246|CRT matches to NZ_CP013710 (Clostridium botulinum strain F634 plasmid pRSJ2_3, complete sequence) position: , mismatch: 6, identity: 0.864

ttgttcaactgaaatatctggaataaatctatttgacatatcac	CRISPR spacer
tacagcaggtgaaatatctggaataaatctatttgacatatcac	Protospacer
*    **. ***********************************

26. spacer 2.1|698402|44|NZ_CP013246|CRT matches to NC_010418 (Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence) position: , mismatch: 6, identity: 0.864

ttgttcaactgaaatatctggaataaatctatttgacatatcac	CRISPR spacer
tacagcaggtgaaatatctggaataaatctatttgacatatcac	Protospacer
*    **. ***********************************

27. spacer 2.1|698402|44|NZ_CP013246|CRT matches to NZ_CP013700 (Clostridium botulinum strain AM1195 plasmid pRSJ11_1, complete sequence) position: , mismatch: 6, identity: 0.864

ttgttcaactgaaatatctggaataaatctatttgacatatcac	CRISPR spacer
tacagcaggtgaaatatctggaataaatctatttgacatatcac	Protospacer
*    **. ***********************************

28. spacer 2.1|698402|44|NZ_CP013246|CRT matches to NC_012654 (Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence) position: , mismatch: 6, identity: 0.864

ttgttcaactgaaatatctggaataaatctatttgacatatcac	CRISPR spacer
tacagcaggtgaaatatctggaataaatctatttgacatatcac	Protospacer
*    **. ***********************************

29. spacer 2.1|698402|44|NZ_CP013246|CRT matches to NZ_CP031095 (Clostridium botulinum strain CFSAN034200 plasmid p1_CDC51232, complete sequence) position: , mismatch: 6, identity: 0.864

ttgttcaactgaaatatctggaataaatctatttgacatatcac	CRISPR spacer
tacagcaggtgaaatatctggaataaatctatttgacatatcac	Protospacer
*    **. ***********************************

30. spacer 2.3|698534|43|NZ_CP013246|CRT matches to NZ_CP013682 (Clostridium botulinum strain 1169 plasmid pRSJ8_1, complete sequence) position: , mismatch: 6, identity: 0.86

ctgttcaac--gcacaagctaaattagtttttaataatacaccca	CRISPR spacer
--gctaaccctgcacaagctaaattagtttttaataatactccca	Protospacer
  *.* * *  ***************************** ****

31. spacer 2.3|698534|43|NZ_CP013246|CRT matches to NZ_CP013295 (Clostridium botulinum strain CDC_54064 plasmid pNPD1_1, complete sequence) position: , mismatch: 6, identity: 0.86

ctgttcaac--gcacaagctaaattagtttttaataatacaccca	CRISPR spacer
--gctaaccctgcacaagctaaattagtttttaataatactccca	Protospacer
  *.* * *  ***************************** ****

32. spacer 2.1|698402|44|NZ_CP013246|CRT matches to NZ_CP013684 (Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence) position: , mismatch: 7, identity: 0.841

ttgttcaactgaaatatctggaataaatctatttgacatatcac	CRISPR spacer
tacagcaggtgaaatatctggaataaatctatttgatatatcac	Protospacer
*    **. ***************************.*******

33. spacer 2.3|698534|43|NZ_CP013246|CRT matches to NZ_CP013709 (Clostridium botulinum strain F634 plasmid pRSJ2_2, complete sequence) position: , mismatch: 7, identity: 0.837

ctgttcaac--gcacaagctaaattagtttttaataatacaccca	CRISPR spacer
--gctaaccctgcacaagcgaaattagtttttaataacacaccca	Protospacer
  *.* * *  ******** *****************.*******

34. spacer 2.3|698534|43|NZ_CP013246|CRT matches to NZ_CP013844 (Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence) position: , mismatch: 7, identity: 0.837

ctgttcaac--gcacaagctaaattagtttttaataatacaccca	CRISPR spacer
--gctaaccctgcacaagcgaaattagtttttaataacacaccca	Protospacer
  *.* * *  ******** *****************.*******

35. spacer 2.1|698402|44|NZ_CP013246|CRT matches to NC_025146 (Clostridium botulinum plasmid pCB111 DNA, complete sequence, strain: 111) position: , mismatch: 8, identity: 0.818

ttgttcaactgaaatatctggaataaatctatttgacatatcac	CRISPR spacer
tacagcaggtgaagtgtctggaataaatctatttgacatatcac	Protospacer
*    **. ****.*.****************************

36. spacer 2.6|698544|35|NZ_CP013246|PILER-CR matches to AP014086 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C3-MedDCM-OCT-S45-C97, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.743

gcacaagctaaattagtttttaataatacacccat	CRISPR spacer
gtaggagataaattagtttttgataatacaggaac	Protospacer
*.* .** *************.********   *.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

76406 : 84611

uncultured_phage(33.33%)

protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003358714.1\|76406_77351_-	YafY family transcriptional regulator	A0A1B0RXM1	Streptococcus_phage	3.2e-14	31.1
WP_003358556.1\|77970_78966_+	2-hydroxyglutaryl-CoA dehydratase	NA	NA	NA	NA
WP_003358645.1\|79082_79844_+	2-hydroxyglutaryl-CoA dehydratase	NA	NA	NA	NA
WP_003358723.1\|79861_80293_+	6-carboxytetrahydropterin synthase QueD	A0A1U9WRB3	Streptococcus_virus	1.4e-12	33.1
WP_003358633.1\|80294_80960_+	putative 7-carboxy-7-deazaguanine synthase QueE	S4TZT1	uncultured_phage	1.4e-37	44.6
WP_003358544.1\|80963_81554_+	GTP cyclohydrolase I FolE	S4U0J3	uncultured_phage	9.8e-46	54.5
WP_003358784.1\|81737_82388_+	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	1.7e-59	51.2
WP_003358688.1\|82689_83508_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_071647142.1\|83654_84611_+	chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	7.2e-14	38.6

DBSCAN-SWA_2

172103 : 234752

Clostridium_phage(65.12%)

coat,head,tail,holin,terminase,plate,integrase

attL 194131:194162|attR 240680:240711

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003359081.1\|172103_173249_+\|holin	betaine/proline/choline family ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	1.1e-16	36.9
WP_071647160.1\|173241_174825_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_071647161.1\|175118_176600_+	threonine synthase	NA	NA	NA	NA
WP_071647162.1\|176609_177503_+	homoserine kinase	NA	NA	NA	NA
WP_003359029.1\|177629_178949_+	aspartate kinase	NA	NA	NA	NA
WP_003359088.1\|179169_180447_+	homoserine dehydrogenase	NA	NA	NA	NA
WP_003358936.1\|181132_183043_+	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_003358990.1\|183551_184718_+	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_003358986.1\|185046_185934_+	sulfide/dihydroorotate dehydrogenase-like FAD/NAD-binding protein	NA	NA	NA	NA
WP_003359035.1\|185933_187316_+	NADPH-dependent glutamate synthase	NA	NA	NA	NA
WP_071647163.1\|187544_189509_+	AAA domain-containing protein	NA	NA	NA	NA
WP_003359059.1\|189515_190217_+	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_106574553.1\|190495_190609_+	hypothetical protein	NA	NA	NA	NA
WP_003358842.1\|190640_191729_+	Ig domain-containing protein	E5AFW9	Erwinia_phage	5.5e-10	33.8
WP_031367703.1\|191822_192041_+	hypothetical protein	A0A0A7RTM8	Clostridium_phage	2.2e-11	71.4
WP_155119175.1\|192215_192368_+	hypothetical protein	NA	NA	NA	NA
WP_003358874.1\|192726_192888_+	DUF1508 domain-containing protein	NA	NA	NA	NA
WP_003359075.1\|193726_193942_+	hypothetical protein	NA	NA	NA	NA
194131:194162	attL	NA	NA	NA	NA
WP_079994968.1\|194440_194677_+	hypothetical protein	NA	NA	NA	NA
WP_003359066.1\|194832_195384_+	DUF4352 domain-containing protein	A0A0S2MVG4	Bacillus_phage	2.5e-11	31.6
WP_003359046.1\|195421_195709_+	Fis family transcriptional regulator	NA	NA	NA	NA
WP_071647164.1\|196294_197368_-\|integrase	site-specific integrase	A0A2R2ZGM9	Clostridioides_phage	3.7e-19	29.8
WP_012720639.1\|197429_197876_-	ImmA/IrrE family metallo-endopeptidase	Q0H245	Geobacillus_phage	2.2e-26	42.8
WP_071647165.1\|197894_198320_-	helix-turn-helix transcriptional regulator	D2XR39	Bacillus_phage	5.8e-32	58.0
WP_071647166.1\|198547_198751_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_071647167.1\|198767_199067_+	hypothetical protein	NA	NA	NA	NA
WP_080488611.1\|199087_199951_+	phage antirepressor KilAC domain-containing protein	A0A090D834	Clostridium_phage	6.8e-80	59.0
WP_061294726.1\|199942_200209_-	hypothetical protein	NA	NA	NA	NA
WP_080488612.1\|200572_200896_+	hypothetical protein	NA	NA	NA	NA
WP_071647168.1\|201071_201869_+	recombinase RecT	H7BUU1	unidentified_phage	4.2e-60	54.3
WP_080488648.1\|201900_202653_+	hypothetical protein	A0A0A7RVR3	Clostridium_phage	6.3e-74	55.4
WP_071647170.1\|202663_202948_+	hypothetical protein	NA	NA	NA	NA
WP_071647171.1\|202970_203765_+	DnaD domain protein	A8ATY7	Listeria_phage	3.5e-38	37.8
WP_080488614.1\|203697_204465_+	MerR family transcriptional regulator	M9Q1J4	Clostridium_phage	7.7e-51	46.2
WP_071647172.1\|204476_204755_+	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_155119176.1\|204791_204950_+	hypothetical protein	NA	NA	NA	NA
WP_071647173.1\|204962_205778_+	hypothetical protein	NA	NA	NA	NA
WP_155119177.1\|205807_205972_+	hypothetical protein	NA	NA	NA	NA
WP_071647174.1\|206009_206306_+	hypothetical protein	NA	NA	NA	NA
WP_071647175.1\|206385_206688_+	hypothetical protein	A0A172JIH8	Bacillus_phage	9.2e-16	69.6
WP_155119178.1\|206794_207178_+	hypothetical protein	I2E8X6	Clostridium_phage	1.9e-13	34.1
WP_071647176.1\|207346_207700_+	Holliday junction resolvase	A0A0A7S133	Clostridium_phage	1.0e-50	79.3
WP_071647177.1\|207701_208085_+	hypothetical protein	NA	NA	NA	NA
WP_071647178.1\|208085_208412_+	hypothetical protein	A0A0A7RWJ7	Clostridium_phage	8.7e-20	46.6
WP_155119179.1\|208424_208601_+	hypothetical protein	NA	NA	NA	NA
WP_071647179.1\|208752_209271_+	sigma-70 family RNA polymerase sigma factor	A0A0A7RVS1	Clostridium_phage	1.4e-16	30.8
WP_012705283.1\|209654_209894_+	peptidase	NA	NA	NA	NA
WP_071647180.1\|210157_210868_+	GIY-YIG nuclease family protein	A0A2I7S3T0	Vibrio_phage	2.4e-06	36.2
WP_045904665.1\|211029_211212_+	aspartyl-phosphate phosphatase Spo0E family protein	NA	NA	NA	NA
WP_071647181.1\|211297_211507_+	hypothetical protein	NA	NA	NA	NA
WP_071647182.1\|211605_212175_+\|terminase	terminase small subunit	Q6SED9	Lactobacillus_prophage	2.8e-13	33.3
WP_071647183.1\|212164_213403_+\|terminase	PBSX family phage terminase large subunit	A0A0A7RTE7	Clostridium_phage	1.4e-222	91.0
WP_031368395.1\|214657_216484_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	1.1e-87	37.4
WP_080488616.1\|217348_218380_+\|head	phage head morphogenesis protein	A0A0A7RVY7	Clostridium_phage	1.1e-148	77.3
WP_155119180.1\|218468_218615_+	hypothetical protein	NA	NA	NA	NA
WP_071647185.1\|218598_218967_-	DUF2513 domain-containing protein	A0A1S5SCT1	Streptococcus_phage	1.1e-23	45.2
WP_071647186.1\|219140_219704_+	scaffolding protein	A0A0A7RTM5	Clostridium_phage	4.2e-22	42.6
WP_071647187.1\|219726_220794_+\|coat	phage coat protein	A0A0A7RTH8	Clostridium_phage	7.2e-180	88.5
WP_071647944.1\|220811_221156_+	hypothetical protein	A0A0A7RTX9	Clostridium_phage	2.1e-48	85.1
WP_071647188.1\|221157_221544_+	hypothetical protein	A0A0A7S083	Clostridium_phage	3.1e-40	73.6
WP_071647189.1\|221543_222035_+	HK97 gp10 family phage protein	A0A0A7RTT0	Clostridium_phage	1.2e-60	73.5
WP_071647190.1\|222048_222330_+	hypothetical protein	A0A0A7RTM9	Clostridium_phage	3.0e-21	62.2
WP_071647191.1\|222280_222511_-	hypothetical protein	NA	NA	NA	NA
WP_071647192.1\|222563_222995_+	hypothetical protein	A0A0A7RTI2	Clostridium_phage	4.6e-53	75.4
WP_071647193.1\|223156_224467_+\|tail	phage tail sheath protein	A0A0A7S087	Clostridium_phage	1.5e-211	83.9
WP_071647194.1\|224470_224935_+\|tail	phage tail tube protein	A0A0A7RVP1	Clostridium_phage	6.0e-67	80.5
WP_071647195.1\|224950_225364_+	hypothetical protein	A0A0A7RTN3	Clostridium_phage	3.7e-52	74.8
WP_012703789.1\|225604_226183_+	hypothetical protein	A0A0A7RTT9	Clostridium_phage	2.3e-55	56.1
WP_071647196.1\|226268_228428_+	hypothetical protein	A0A0A7S091	Clostridium_phage	1.2e-133	52.7
WP_071647197.1\|228427_229090_+	LysM peptidoglycan-binding domain-containing protein	A0A0A7RVP5	Clostridium_phage	2.2e-94	76.1
WP_012721239.1\|229101_230076_+	hypothetical protein	A0A0A7RTZ4	Clostridium_phage	4.3e-155	84.3
WP_071647198.1\|230078_230423_+	DUF2577 domain-containing protein	A0A0A7RTJ2	Clostridium_phage	8.0e-40	78.1
WP_012720785.1\|230425_230836_+	DUF2634 domain-containing protein	A0A0A7RTH1	Clostridium_phage	2.5e-48	75.6
WP_071647199.1\|230836_231931_+\|plate	baseplate J/gp47 family protein	A0A0A7S096	Clostridium_phage	3.8e-160	76.7
WP_012721289.1\|231911_232538_+	DUF2313 domain-containing protein	A0A0A7RVP9	Clostridium_phage	2.1e-86	75.6
WP_071647200.1\|233173_233632_+	hypothetical protein	NA	NA	NA	NA
WP_071647201.1\|233631_234192_+	hypothetical protein	NA	NA	NA	NA
WP_071647202.1\|234205_234565_+	hypothetical protein	A0A2H4J342	uncultured_Caudovirales_phage	4.7e-19	53.3
WP_071647203.1\|234566_234752_+	hypothetical protein	A0A2H4JGH3	uncultured_Caudovirales_phage	1.3e-09	67.4
240680:240711	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1072766 : 1106940

uncultured_Caudovirales_phage(32.26%)

tail,portal,capsid,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_071647419.1\|1072766_1073534_-	SH3 domain-containing protein	A0A2H4J8A3	uncultured_Caudovirales_phage	3.5e-88	65.1
WP_014521308.1\|1073575_1073770_-	hypothetical protein	NA	NA	NA	NA
WP_071647420.1\|1073783_1074038_-	hypothetical protein	A0A0A7RTX0	Clostridium_phage	2.7e-13	46.8
WP_080488628.1\|1074074_1075097_-	DNA (cytosine-5-)-methyltransferase	A0A219UR24	Bacillus_phage	4.9e-69	42.4
WP_003400227.1\|1075205_1075328_-	XkdX family protein	A0A0A7S0E7	Clostridium_phage	5.9e-06	55.0
WP_071647421.1\|1075320_1075686_-	hypothetical protein	NA	NA	NA	NA
WP_071647422.1\|1075698_1077528_-	PQQ-binding-like beta-propeller repeat protein	E2ELJ8	Clostridium_phage	4.4e-52	57.8
WP_071647423.1\|1077535_1078693_-	hypothetical protein	A0A0K2CZQ1	Paenibacillus_phage	6.1e-60	33.3
WP_155119189.1\|1078708_1078861_-	hypothetical protein	NA	NA	NA	NA
WP_155119203.1\|1078888_1079725_-\|tail	phage tail family protein	E2ELJ6	Clostridium_phage	1.3e-43	38.8
WP_071647425.1\|1079779_1082842_-\|tail	phage tail tape measure protein	A0A0A7S163	Clostridium_phage	6.9e-135	81.9
WP_033066337.1\|1082842_1083145_-	hypothetical protein	NA	NA	NA	NA
WP_071647426.1\|1083153_1083465_-	hypothetical protein	NA	NA	NA	NA
WP_071647427.1\|1083477_1083999_-	hypothetical protein	NA	NA	NA	NA
WP_071647428.1\|1083995_1084364_-	hypothetical protein	NA	NA	NA	NA
WP_071647429.1\|1084384_1084801_-	hypothetical protein	A0A0S2MVE4	Bacillus_phage	2.8e-07	40.2
WP_071647430.1\|1084793_1085117_-	hypothetical protein	NA	NA	NA	NA
WP_071647431.1\|1085116_1085413_-	hypothetical protein	D7RWJ1	Brochothrix_phage	1.0e-06	31.9
WP_155119204.1\|1085396_1085693_-	hypothetical protein	A0A2H4PQK8	Staphylococcus_phage	3.2e-05	58.5
WP_071647433.1\|1085702_1086686_-\|capsid	phage capsid protein	A0A1V0E621	Streptomyces_phage	2.3e-68	46.0
WP_071647434.1\|1086707_1087256_-	hypothetical protein	A0A0A8WEG1	Clostridium_phage	5.0e-20	38.7
WP_071647435.1\|1087385_1087751_-	ABC transporter ATPase	A0A2H4J4N9	uncultured_Caudovirales_phage	5.1e-29	58.7
WP_071647436.1\|1087816_1088038_-	hypothetical protein	NA	NA	NA	NA
WP_080488630.1\|1088039_1089224_-	hypothetical protein	H7BWE7	unidentified_phage	2.5e-24	33.5
WP_071647437.1\|1089213_1090641_-\|portal	phage portal protein	A0A0A8WIH2	Clostridium_phage	1.8e-106	44.5
WP_155119206.1\|1090653_1091922_-\|terminase	PBSX family phage terminase large subunit	A0A0M4R5F3	Bacillus_phage	2.4e-150	60.7
WP_071647438.1\|1091905_1092346_-\|terminase	terminase small subunit	S5MA50	Brevibacillus_phage	1.6e-37	60.9
WP_071647439.1\|1092445_1092637_-	hypothetical protein	NA	NA	NA	NA
WP_071647440.1\|1092823_1093261_-	siderophore-interacting protein	A0A0A7RTX6	Clostridium_phage	1.9e-14	35.0
WP_155119190.1\|1093637_1093805_-	hypothetical protein	NA	NA	NA	NA
WP_071647441.1\|1093816_1094008_-	hypothetical protein	NA	NA	NA	NA
WP_071647442.1\|1094045_1095911_-	DNA primase	A0A2H4J1M0	uncultured_Caudovirales_phage	0.0e+00	87.9
WP_155119191.1\|1096116_1096272_+	hypothetical protein	NA	NA	NA	NA
WP_071647443.1\|1096478_1096808_-	nucleoside triphosphate pyrophosphohydrolase family protein	A0A2H4J7H8	uncultured_Caudovirales_phage	1.7e-44	79.4
WP_071647956.1\|1096808_1097087_-	DUF1599 domain-containing protein	A0A2H4J4N1	uncultured_Caudovirales_phage	1.5e-25	74.7
WP_071647444.1\|1097546_1097960_-	hypothetical protein	NA	NA	NA	NA
WP_071647445.1\|1098166_1099861_-	hypothetical protein	A0A2H4J041	uncultured_Caudovirales_phage	1.6e-287	83.0
WP_014521346.1\|1099860_1100049_-	hypothetical protein	A0A0A7S0P6	Clostridium_phage	3.3e-16	65.0
WP_071647446.1\|1100102_1100558_-	DUF669 domain-containing protein	A0A2H4J1S8	uncultured_Caudovirales_phage	3.7e-53	65.3
WP_155119192.1\|1100558_1100708_-	hypothetical protein	NA	NA	NA	NA
WP_071647447.1\|1100707_1102399_-	AAA family ATPase	A0A2H4J7Q2	uncultured_Caudovirales_phage	1.3e-260	89.7
WP_071647957.1\|1102444_1102741_-	VRR-NUC domain-containing protein	A0A2H4J095	uncultured_Caudovirales_phage	6.0e-44	88.5
WP_071647448.1\|1102737_1102920_-	hypothetical protein	NA	NA	NA	NA
WP_071647449.1\|1102937_1103312_-	hypothetical protein	NA	NA	NA	NA
WP_080488632.1\|1103312_1104482_-	DEAD/DEAH box helicase	A0A2H4J064	uncultured_Caudovirales_phage	9.6e-170	74.3
WP_080488633.1\|1104595_1105159_-	hypothetical protein	E5DV63	Deep-sea_thermophilic_phage	1.2e-24	43.7
WP_014521358.1\|1105590_1105788_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_071647451.1\|1106009_1106453_+	helix-turn-helix transcriptional regulator	A0A0A7RTK4	Clostridium_phage	4.8e-13	34.9
WP_071647452.1\|1106472_1106940_+	ImmA/IrrE family metallo-endopeptidase	Q0H245	Geobacillus_phage	9.2e-07	28.6

DBSCAN-SWA_4

1493057 : 1502541

Synechococcus_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_031367308.1\|1493057_1494557_-	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	1.1e-69	46.9
WP_003357901.1\|1494770_1495388_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.5e-25	40.6
WP_003357871.1\|1495515_1496511_-	phosphoribosylformylglycinamidine cyclo-ligase	M4QRQ6	Synechococcus_phage	3.4e-67	44.0
WP_003385256.1\|1496571_1498020_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	7.2e-58	35.1
WP_003358103.1\|1498111_1498816_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	G8EYA2	Synechococcus_phage	1.0e-41	42.1
WP_003357851.1\|1498815_1499295_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	1.1e-26	48.7
WP_003357858.1\|1499815_1499950_+	hypothetical protein	NA	NA	NA	NA
WP_079994953.1\|1499970_1502541_-	selenium-dependent xanthine dehydrogenase	A0A0P0IVM8	Acinetobacter_phage	1.3e-09	32.4

DBSCAN-SWA_5

1651964 : 1673836

Clostridium_phage(85.71%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_071647540.1\|1651964_1653050_-	signal peptidase II	A0A0A7RU66	Clostridium_phage	3.9e-141	69.8
WP_071647541.1\|1653061_1654060_-	hypothetical protein	A0A0A7RW91	Clostridium_phage	2.0e-139	72.6
WP_030036513.1\|1654071_1654326_-	hypothetical protein	A0A0A7S0T0	Clostridium_phage	1.1e-33	81.0
WP_071647542.1\|1654331_1656227_-	hypothetical protein	A0A0A7RU09	Clostridium_phage	1.5e-111	55.4
WP_071647543.1\|1656241_1657495_-	hypothetical protein	A0A0A7RU28	Clostridium_phage	2.5e-192	78.2
WP_071647545.1\|1657517_1658495_-	hypothetical protein	A0A0A7RU61	Clostridium_phage	1.9e-110	61.1
WP_071647547.1\|1658496_1659837_-	caspase family protein	A0A0A7RW86	Clostridium_phage	2.1e-75	74.6
WP_071647549.1\|1659851_1660193_-	hypothetical protein	A0A0A7S0S4	Clostridium_phage	1.6e-16	55.7
WP_071647550.1\|1660205_1661291_-	hypothetical protein	NA	NA	NA	NA
WP_025774830.1\|1661277_1661712_-	hypothetical protein	NA	NA	NA	NA
WP_025774832.1\|1661724_1663128_-	hypothetical protein	A0A0A7RU22	Clostridium_phage	6.9e-05	42.4
WP_003357826.1\|1663291_1663459_-	hypothetical protein	A0A0A7RW80	Clostridium_phage	1.9e-15	70.4
WP_071647551.1\|1663493_1663910_-	esterase	A0A0A7S0S0	Clostridium_phage	3.4e-45	70.5
WP_012704139.1\|1663924_1664812_-	hypothetical protein	A0A0A7RTZ9	Clostridium_phage	2.4e-120	74.8
WP_012704829.1\|1664816_1665236_-	hypothetical protein	A0A0A7RU17	Clostridium_phage	7.1e-59	73.4
WP_012704384.1\|1665241_1665589_-	hypothetical protein	A0A0A7RU51	Clostridium_phage	1.5e-33	60.7
WP_003357709.1\|1665593_1665959_-	hypothetical protein	A0A0A7RW73	Clostridium_phage	1.2e-33	57.9
WP_003357791.1\|1665958_1666243_-	hypothetical protein	A0A0A7S0R4	Clostridium_phage	3.0e-24	59.2
WP_012704555.1\|1666909_1667431_-	hypothetical protein	A0A0A7RVS1	Clostridium_phage	1.1e-35	50.0
WP_012704130.1\|1667543_1667864_-	hypothetical protein	NA	NA	NA	NA
WP_071647552.1\|1667920_1668769_-	ATP-binding protein	A0A2K9V3L7	Faecalibacterium_phage	8.0e-33	34.8
WP_061310459.1\|1668710_1669616_-	hypothetical protein	A8ASN4	Listeria_phage	3.6e-39	39.9
WP_072570747.1\|1669709_1669943_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_025774852.1\|1669983_1670193_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_003360073.1\|1670384_1670795_+	helix-turn-helix domain-containing protein	A0A0A7RUJ5	Clostridium_phage	1.0e-09	56.2
WP_003357837.1\|1671096_1671246_+	hypothetical protein	NA	NA	NA	NA
WP_003357882.1\|1672348_1673836_+	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	4.3e-66	38.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP013246

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection