CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP018094	Francisella hispaniensis FSC454 strain CCUG 58020 plasmid pFSC454, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP018093	Francisella hispaniensis FSC454 strain CCUG 58020 chromosome, complete genome	2 crisprs	cas3,csa3,DEDDh,cas9,cas2,cas4,cas1	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018093_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018093_1

987198-987816

TypeII

Consensus_repeat	Method
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAAC	PILER-CR
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAAC	CRISPRCasFinder
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAAC	CRT
AGTATATCAAATAATCTAGTTACTGAAACTTA	PILER-CR

8 spacers

cas4,cas2,cas9

The CRISPR arrays of NZ_CP018093_1

>merge|NZ_CP018093|1|987198-987816|PILER-CR,CRISPRCasFinder,CRT,PILER-CR
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAACTCACAAAAGCATCTGCTTTGTTAGGTGAATTAATACTAACAGCAGTATATCAAATAATCTAGCTACTGAAACCTTAAAGCTCCACTGGATAATGCTTGACCTAGTTGCTAACAGCAGTATATCAAATAATCTAGCTACTGAAACACATAATAACCATCAGGCTTATCATTACTAGAGCTAACAGCAGTATATCAAATAATCTAGCTTCTTATAAATAACACTAATACCTAGCATCAAGCAGGTAAGTTTTTATTGTACATCAAATAACCTAGCTACCGAAACTTAATTAATTTTACGAATAATATTTAGAAGTTTCTATCTGAGTAAAGTATATCAGATAATATAACCGCTAAAATAGTTATATAGCAAAATATTAATTCAAGTACAGTATTCAAAGCAGTATATCAAATAACCTAATTAATGAAAATTTACAGCTAATTGTTCTTTATATGTCAGGTTAATCCTAACTATAACACTAGTATGTACCAAATAATCTAGCTACTGAAACTTACAGCTAATCTTTTTTCATTTGCTGGACTGATCCTAAGATAGTATATCAGATAATCTAGTAACTGAAACTTA

>NZ_CP018093|1|1|987198-987378|PILER-CR
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAAC	TCACAAAAGCATCTGCTTTGTTAGGTGAATTAATA
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAAC	CTTAAAGCTCCACTGGATAATGCTTGACCTAGTTG
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAACACATAATAACCATCAGGCTTATCATTACTAGAGCTAACAGCAGTATATCAAATAATCTAGCTTCTTATAAATAACACTAATACCTAGCATCAAGCAGGTAAGTTTTTATTGTACATCAAATAACCTAGCTACCGAAACTTAATTAATTTTACGAATAATATTTAGAAGTTTCTATCTGAGTAAAGTATATCAGATAATATAACCGCTAAAATAGTTATATAGCAAAATATTAATTCAAGTACAGTATTCAAAGCAGTATATCAAATAACCTAATTAATGAAAATTT	ACAGCTAATTGTTCTTTATATGTCAGGTTAATCCTAACTATAACACTAGTATGTACC
AAATAATCTAGCTACTGAAACTTACAGCTAAT	CTTTTTTCATTTGCTGGACTGATCCTAAGATAGTATATC


>NZ_CP018093|1|1|987198-987813|CRISPRCasFinder
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAAC	TCACAAAAGCATCTGCTTTGTTAGGTGAATTAATA
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAAC	CTTAAAGCTCCACTGGATAATGCTTGACCTAGTTG
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAAC	ACATAATAACCATCAGGCTTATCATTACTAGAG
CTAACAGCAGTATATCAAATAATCTAGCTTCTTATAA	ATAACACTAATACCTAGCATCAAGCAGGTAA
GTTTTTATTGTACATCAAATAACCTAGCTACCGAAAC	TTAATTAATTTTACGAATAATATTTAGAAGTTTCTAT
CTGAGTAAAGTATATCAGATAATATAACCGCTAAAAT	AGTTATATAGCAAAATATTAATTCAAGTACAGTA
TTCAAAGCAGTATATCAAATAACCTAATTAATGAAAA	TTTACAGCTAATTGTTCTTTATATGTCAGGTTAATCCTAACTAT
AACACTAGTATGTACCAAATAATCTAGCTACTGAAAC	TTACAGCTAATCTTTTTTCATTTGCTGGACTGAT
CCTAAGATAGTATATCAGATAATCTAGTAACTGAAAC

>NZ_CP018093|1|1|987198-987448|CRT
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAAC	TCACAAAAGCATCTGCTTTGTTAGGTGAATTAATA
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAAC	CTTAAAGCTCCACTGGATAATGCTTGACCTAGTTG
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAAC	ACATAATAACCATCAGGCTTATCATTACTAGAG
CTAACAGCAGTATATCAAATAATCTAGCTTCTTATAA

>NZ_CP018093|1|2|987633-987816|PILER-CR
	TCACAAAAGCATCTGCTTTGTTAGGTGAATTAATA
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAAC	CTTAAAGCTCCACTGGATAATGCTTGACCTAGTTG
CTAACAGCAGTATATCAAATAATCTAGCTACTGAAACACATAATAACCATCAGGCTTATCATTACTAGAGCTAACAGCAGTATATCAAATAATCTAGCTTCTTATAAATAACACTAATACCTAGCATCAAGCAGGTAAGTTTTTATTGTACATCAAATAACCTAGCTACCGAAACTTAATTAATTTTACGAATAATATTTAGAAGTTTCTATCTGAGTAAAGTATATCAGATAATATAACCGCTAAAATAGTTATATAGCAAAATATTAATTCAAGTACAGTATTCAAAGCAGTATATCAAATAACCTAATTAATGAAAATTT	ACAGCTAATTGTTCTTTATATGTCAGGTTAATCCTAACTATAACACTAGTATGTACC
AAATAATCTAGCTACTGAAACTTACAGCTAAT	CTTTTTTCATTTGCTGGACTGATCCTAAGATAGTATATC
AGATAATCTAGTAACTGAAACTTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018093.1\|WP_066046305.1\|994508_994985_-\|tryptophan-rich-sensory-protein	unknown	unknown	gnl\|CDD\|320706
NZ_CP018093.1\|WP_066046382.1\|974821_976045_+\|SufS-family-cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_CP018093.1\|WP_066046315.1\|990606_991575_-\|linear-amide-C-N-hydrolase	unknown	unknown	gnl\|CDD\|225591
NZ_CP018093.1\|WP_066046379.1\|976997_977486_+\|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234674
NZ_CP018093.1\|WP_066046381.1\|976065_976422_+\|iron-sulfur-cluster-assembly-accessory-protein	unknown	unknown	gnl\|CDD\|223393
NZ_CP018093.1\|WP_066046383.1\|973346_974720_+\|L-serine-ammonia-lyase	unknown	unknown	gnl\|CDD\|273233
NZ_CP018093.1\|WP_066046304.1\|995114_995969_+\|bifunctional-methionine-sulfoxide-reductase-B/A-protein	unknown	unknown	gnl\|CDD\|235499
NZ_CP018093.1\|WP_066046525.1\|986162_986747_+\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NZ_CP018093.1\|WP_066046380.1\|976435_976987_+\|putative-Fe-S-cluster-assembly-protein-SufT	unknown	unknown	gnl\|CDD\|213809
NZ_CP018093.1\|WP_066046307.1\|991671_992424_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349968
NZ_CP018093.1\|WP_066046309.1\|989574_990024_+\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NZ_CP018093.1\|WP_066046310.1\|989329_989578_+\|glutaredoxin	unknown	unknown	gnl\|CDD\|239510
NZ_CP018093.1\|WP_066046378.1\|977491_977737_+\|YfhL-family-4Fe-4S-dicluster-ferredoxin	unknown	unknown	gnl\|CDD\|235941
NZ_CP018093.1\|WP_066046311.1\|988251_989337_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275338
NZ_CP018093.1\|WP_066046306.1\|992563_994516_+\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_CP018093.1\|WP_066046523.1\|979940_984860_+\|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12	cas9	cd09704_cas9_CAS-II-B	gnl\|CDD\|274401
NZ_CP018093.1\|WP_014548417.1\|985882_986176_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856
NZ_CP018093.1\|WP_066046377.1\|977838_979017_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NZ_CP018093.1\|WP_066046308.1\|990039_990393_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018093.1\|WP_066046303.1\|995965_997168_-\|multidrug-effflux-MFS-transporter	unknown	unknown	gnl\|CDD\|340878

Protein	Function_ID	Function_description	E-value
NZ_CP018093.1\|WP_066046382.1\|974821_976045_+\|SufS-family-cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP018093.1\|WP_066046315.1\|990606_991575_-\|linear-amide-C-N-hydrolase	gnl\|CDD\|225591	COG3049, COG3049, Penicillin V acylase and related amidases [Cell envelope biogenesis, outer membrane].	5.80147e-69
NZ_CP018093.1\|WP_066046379.1\|976997_977486_+\|pantetheine-phosphate-adenylyltransferase	gnl\|CDD\|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	1.50769e-86
NZ_CP018093.1\|WP_066046381.1\|976065_976422_+\|iron-sulfur-cluster-assembly-accessory-protein	gnl\|CDD\|223393	COG0316, sufA, Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones].	1.65754e-27
NZ_CP018093.1\|WP_066046383.1\|973346_974720_+\|L-serine-ammonia-lyase	gnl\|CDD\|273233	TIGR00720, hypothetical_protein_NEICINOT_00681, L-serine dehydratase, iron-sulfur-dependent, single chain form. This enzyme is also called serine deaminase and L-serine dehydratase 1. L-serine ammonia-lyase converts serine into pyruvate in the gluconeogenesis pathway from serine. This enzyme is comprised of a single chain in Escherichia coli, Mycobacterium tuberculosis, and several other species, but has separate alpha and beta chains in Bacillus subtilis and related species. The beta and alpha chains are homologous to the N-terminal and C-terminal regions, respectively, but are rather deeply branched in a UPGMA tree. This enzyme requires iron and dithiothreitol for activation in vitro, and is a predicted 4Fe-4S protein. Escherichia coli Pseudomonas aeruginosa have two copies of this protein. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	0
NZ_CP018093.1\|WP_066046304.1\|995114_995969_+\|bifunctional-methionine-sulfoxide-reductase-B/A-protein	gnl\|CDD\|235499	PRK05550, PRK05550, bifunctional methionine sulfoxide reductase B/A protein; Provisional.	0
NZ_CP018093.1\|WP_066046525.1\|986162_986747_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	2.85462e-24
NZ_CP018093.1\|WP_066046380.1\|976435_976987_+\|putative-Fe-S-cluster-assembly-protein-SufT	gnl\|CDD\|213809	TIGR03406, FeS_long_SufT, probable FeS assembly SUF system protein SufT. The function is unknown for this protein family, but members are found almost always in operons for the the SUF system of iron-sulfur cluster biosynthesis. The SUF system is present elsewhere on the chromosome for those few species where SUF genes are not adjacent. This family shares this property of association with the SUF system with a related family, TIGR02945. TIGR02945 consists largely of a DUF59 domain (see pfam01883), while this protein is about double the length, with a unique N-terminal domain and DUF59 C-terminal domain. A location immediately downstream of the cysteine desulfurase gene sufS in many contexts suggests the gene symbol sufT. Note that some other homologs of this family and of TIGR02945, but no actual members of this family, are found in operons associated with phenylacetic acid (or other ring-hydroxylating) degradation pathways. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	1.48951e-97
NZ_CP018093.1\|WP_066046305.1\|994508_994985_-\|tryptophan-rich-sensory-protein	gnl\|CDD\|320706	cd15904, TSPO_MBR, Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family. This family contains tryptophan-rich translocator protein (TSPO), an integral membrane protein that is highly conserved from bacteria to mammals. In eukaryotes, it is mainly found in the outer mitochondrial membranes of steroid-synthesizing cells of the nervous system where it transports cholesterol into mitochondria. It is known to be highly expressed in metastatic cancer, steriodogenic tissues, as well as inflammatory and neurological diseases such as Alzheimer's and Parkinson's. TSPO is also known as the peripheral benzodiazepine receptor (MBR) and its ligands include benzodiazepine drugs, implicated in regulating apoptosis. In human, a single polymorphism A147T is associated with psychiatric disorders; the mutation causes structural changes in a region implicated in cholesterol binding. TSPO is homologous to bacterial tryptophan-rich sensory proteins, and their tryptophan residues are believed to be functionally important. In bacteria, TSPO acts as a negative regulator of expression of specific photosynthesis genes in response to oxygen/light; it catalyzes a photooxidative degradation of Proto porphyrine (PpIX). R. sphaeroides TSPO (RsTSPO) is involved in porphyrin transport, similar to human, while Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.	2.41522e-43
NZ_CP018093.1\|WP_066046309.1\|989574_990024_+\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	1.27771e-24
NZ_CP018093.1\|WP_066046310.1\|989329_989578_+\|glutaredoxin	gnl\|CDD\|239510	cd03418, GRX_GRXb_1_3_like, Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide reductase. It contains a redox active CXXC motif in a TRX fold and uses a similar dithiol mechanism employed by TRXs for intramolecular disulfide bond reduction of protein substrates. Unlike TRX, GRX has preference for mixed GSH disulfide substrates, in which it uses a monothiol mechanism where only the N-terminal cysteine is required. The flow of reducing equivalents in the GRX system goes from NADPH -> GSH reductase -> GSH -> GRX -> protein substrates. By altering the redox state of target proteins, GRX is involved in many cellular functions including DNA synthesis, signal transduction and the defense against oxidative stress. Different classes are known including E. coli GRX1 and GRX3, which are members of this subfamily.	6.52117e-13
NZ_CP018093.1\|WP_066046378.1\|977491_977737_+\|YfhL-family-4Fe-4S-dicluster-ferredoxin	gnl\|CDD\|235941	PRK07118, PRK07118, Fe-S cluster domain-containing protein.	1.36021e-07
NZ_CP018093.1\|WP_066046311.1\|988251_989337_+\|radical-SAM-protein	gnl\|CDD\|275338	TIGR04545, rSAM_ahbD_hemeb, heme b synthase. Members of this family are AhbD (alternative heme biosynthetic protein D), a radical SAM enzyme in sulfate-reducing bacteria and methanogens that performs the last decarboxylations to synthesize heme b from Fe-coproporphyrin III. Members include DVU_0855, previously included in error in TIGR04055, the NirJ2 family thought to be involved in heme d1 biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	8.91379e-142
NZ_CP018093.1\|WP_066046306.1\|992563_994516_+\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	0
NZ_CP018093.1\|WP_066046523.1\|979940_984860_+\|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12	gnl\|CDD\|274401	TIGR03031, cas_csx12, CRISPR system subtype II-B RNA-guided endonuclease Cas9/Csx12. Members of this family of CRISPR-associated (cas) protein are found, so far, in CRISPR/cas loci in Wolinella succinogenes DSM 1740, Legionella pneumophila str. Paris, and Francisella tularensis, where the last probably is an example of a degenerate CRISPR locus, having neither repeats nor a functional Cas1. The characteristic repeat length is 37 base pairs and period is about 72. One region of this large protein shows sequence similarity to pfam01844, HNH endonuclease.	0
NZ_CP018093.1\|WP_014548417.1\|985882_986176_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.30046e-06
NZ_CP018093.1\|WP_066046377.1\|977838_979017_+\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	1.18915e-21
NZ_CP018093.1\|WP_066046307.1\|991671_992424_-\|RNA-methyltransferase	gnl\|CDD\|349968	cd18095, SpoU-like_rRNA-MTase, SAM-dependent rRNA methylase related to SpoU-TrmH. RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	3.70668e-52
NZ_CP018093.1\|WP_066046303.1\|995965_997168_-\|multidrug-effflux-MFS-transporter	gnl\|CDD\|340878	cd17320, MFS_MdfA_MDR_like, Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.7037e-75

>NZ_CP018093.1|WP_066046525.1|986162_986747_+|CRISPR-associated-protein-Cas4
MDIFDNDLSIPINLIRQWCFCPRVVYYQELLAIKPHKPLWVAQGEGFHKKVEHLEKRRNFSRYGLDNAIRHFNVTIKSQNYKLHGIVDWVLETDNNVYVVEYKTNPNPNSLGHKLQIAAYALLAQEYFAKPCKTTFLTSDKKSYEIKITDELITKLVKTVNDILNALDSGNKPDSSASDHQCIQCEYLNFCNDR
>NZ_CP018093.1|WP_014548417.1|985882_986176_+|CRISPR-associated-endonuclease-Cas2
MQLRKEYLIAYDIEDNRTRTIIYKQLLAYGLKAVQKSVFWGHISIAELNAIKRLFANSLTISDKIFITRVNMQEQKLEYSFGYDDKTFKDWEEYGHI
>NZ_CP018093.1|WP_066046523.1|979940_984860_+|type-II-B-CRISPR-associated-RNA-guided-endonuclease-Cas9/Csx12
MNIKILPIAIDLGAKNTGVFSAFYQKGTSLESLDNKNGKVYELSKDSYTLLMNNRTARRHQRRGIDRKQLVKRLFKLIWTKQLNLEWNKDTQQTISFLLNRRGFSFITDGYSPEYLNIAPEPVKVILMSILDDYNGEDDLDSYLQSATENDSKIDELYNKLLQKTLEFKLRKLCIDIKEDKVTTKTLKELSNTEFKLLANYLVDYDRILRTQKFSYTDKQGNLRELNYYHHDKYNIQEFLKRNIIINDVILEKLTDDLDIWNLNFDKFDFEKNLEKLENQEDKDYLQTHLHHFVFAVNKIKSEMASGGRHRSQYFQEITNVLVENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGNLSNLELKPLRKYFNDKIHAKADYWDEQKFAETYSDWILGEWRVGAKDKDKKDGAKYSYKILCDELKQKVGINQDGIINQTKGDFVGFLLELDPCRTIPPYLDNNNRKPPKCQSLILNPKFLDNKYPNWQQYLQELKKLQTVQNYLGNFEIDLKDLKSSKEQPYFVKYKSSNQQIASGQRDYKDLDARVLQFIFDRVKASDELLLNEIYSHAKKLKQNISSELEKLELCKKLDKIIANSQLSQILKSQHINGIFEQGTFLHLVCKYYKQRQRARDSRLYIMPEYRYDKKLDKYNNTGRFDDDNQLLTYCNHKPRQKRYQLLNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQKDNRGLLNHKINIARNTKGKCEKEIFNLICKIEGSEDKKGNYKHGLAYELGVLLFGEPNQASKLEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRMQQIKVAKPVEGNKDNIILSAKAQRLPAIPTRIVDGAVKKMATILARNIVDDNWDNIKQALSNNQQLHVPIITESNAFEFEPALADVKGKSLKDKRKKALERINPENTFKDKNNRIKEFAKGISAYSGDNLANGDFDGAKEELDHIIPRAHKKYGTLNDEANLICVTREDNQNRGNKAVFLYDLKPNYKLKQFDTTDDLEIEKKIADTIWDASKQDFKFGNYRSFINLTPQEQKAFRHALFLADENPIKKAVIRAINNRNRTFVNGTQRYFAEVLANNIYLRAKKENLATNRITFDYFGIETTNSNGRGVADVRKLYEKVDSDIQAYAKGDKPQDSYSHLIDAMIAFCVAADEHKNGGSIGLEIDKNYSLYPLDKNTGEVFSKDIFSQIKIADNEFSDKKLVRKKATEGFNTHRQMTRDGIYGESYLPILIHKNLNEVRKGYNWENSEEIKIFKGKKYDIQQLNNLVYCLKFVDKPISIDIQITTLEELRNILETNNISTTAEYYYINLKTQKLHEYYIENYNTALGYKKYTKEMEFLRSLAYRTERVKIKSIDDVSMILAKDSNFKAGKIELPFKTEWQRLYLEWQNTTIKDNYEFLKSYFSVKNATKQHKKVRKDFSLPISTNEGKLLVKRKTWDNNFIYQILNDSDSRADGTKPFIPAFDISKNEIVETIIKSFTSKNIFWLPKNIKLQKVDNKSIFAIDTSRWFEVETPKDLIEIGVSTIQYKIDNNSRPKVRVKLDYVMDDDSKINYFMNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGMTLAGIYNETLNN
>NZ_CP018093.1|WP_066046377.1|977838_979017_+|OmpA-family-protein
MRLKSIVIATTVLLGSATVSIAAGSDNMDTSANTNSATTQSSGFAANNFIAPFANTYSALTNKDNTWGPQDRTGQWYLGVDANGLAGTPNSPSGAGANFTIGYNVNKYFAVQYNQLVGRVFAGLGEGVVNFSNSTMFTPYAAGGAGWANLAGQATGAWDVGGGLKFELSRNVQASVDYRYIQTMAPSNISGANGRAGTNMIGAGLTWFFGGKDTTNNDTGNIQDNGATTAAQTVAMPTIDESKYVLPAGIKQCEGNFNLTEDGVACYTVNGDDVTVYLDTKFAYDKATLNAKGKKAIASFVKFIKDSNISSVTVKGYASQGQTGSEFDIYNQKLSEKRAQAVADYMKQLGLDSEKIITKGFGYDDTLGGIPKSDPRNQRVEASVSAPLKEAN
>NZ_CP018093.1|WP_066046378.1|977491_977737_+|YfhL-family-4Fe-4S-dicluster-ferredoxin
MALLITDECINCDICEPECPNEAISQGEEYYEIDPNKCTECVGHFDESQCTKVCPIRCIIIDPNNIETHQQLLEKYNSLVS
>NZ_CP018093.1|WP_066046379.1|976997_977486_+|pantetheine-phosphate-adenylyltransferase
MNKIAIYPGTFDPITNGHVDLVERALNIFDEIVVAVSTAYGKNTLFDIATREQMIKEVFKDNQRVKVVSFQGLLVDTAVKHNACAIVRGLRAVSDFDYEFQMSSMNNKLNSDIQTIFLTPSEKFSCISSTLVRAVAIHNYKRVDEFVPECVFRKIKLKYSKE
>NZ_CP018093.1|WP_066046380.1|976435_976987_+|putative-Fe-S-cluster-assembly-protein-SufT
MKPTDVTIIRRQVKAVAVPFGNEVELMPGQEVLVTQDKGGSFTLNVNGNLLHLDGKDADAIGKQIVRYPVEEYDIKPGDPINMDAIWDQMRTVYDPEIPVNIVDLGLIYNIITRKLDNGNFHVIIDMTLTAPGCGMGPVLMTDVEKRVAMLPNVDKVDVVMVFDPPWNSEMMTEAAKLELGLF
>NZ_CP018093.1|WP_066046381.1|976065_976422_+|iron-sulfur-cluster-assembly-accessory-protein
MVEVFDPNASSVLEVTDAAAKHFKKHLEKHNGCIGIYVGTKVMGCSGLAYDVDFVRQQPEDTQKVQQHGISFFVSNKSMNFLNGLKIDYVKHDFGLYKLEYTNPNESARCGCGESFTV
>NZ_CP018093.1|WP_066046382.1|974821_976045_+|SufS-family-cysteine-desulfurase
MYDVNKIRQDFPFLAQKINNKSVLFFDTGASAQKPRAVIEFIAEAYAYDYANVHRGVYSLSQEASEKYENVRKIVQNFLNSKSADEIVITKGTTEAINLVASSIGKGIIRSDDEIVVTEMEHHANFVPWQMLCEDKQLAFKVAAIKDNGELDVENLLALVTAKTKILAITLCSNVLGTINPVKEIIKQVRQINPNIIILVDGAQAVIHTKVDVQDLDCDFFVFSGHKLYGPTGVGVLYGKYELLKQLPPYNYGGDMVEEVTISKTTFALPPYRFEAGTPNIVGAIGLGRAIEYVDSIGMSNIEEHEQKLLEYATSELSKITGLTIIGQAKYKAGVITFNIEGCNAGDIGELLAIKGICVRTGKHCAHPLMYRMGVTSTVRMSFGMYNTFEEIDLFIIALKKVISQLK
>NZ_CP018093.1|WP_066046383.1|973346_974720_+|L-serine-ammonia-lyase
MESTFELFSIGVGPSSSHTIGPMRAGCDFINLNKEKLPQTTRVKIDLFGSLALTGKGHKTDYAVVLGVMGFLPESVDIELAKKLYDDCLRNKKLNLGQKFEIDFDYDKDLVFHYNEFLPEHANGMRFSLFDGDELLCEKEYFSIGGGFIVDKKQIKKDTVPTEVPCDKPYKFSTMAELRELCQRDNKTIDEIMFENEKTAYGEQQSLDKLAEIWHVMETSIEKGLTCAEATLPGGLKVRKRAPSMIRKLKEQNIVNTDFNYLNAFAIAVNEQNACGERVVTAPTNGAAGVIPAVLKYYLQTHEIVNQQELKEVVNKYLLVCAAIGILYKSGASISAAEVGCQGEVGVACSMAAAGYCALLGGDLDSIESAAEIGMEHNLGLTCDPIGGLVQIPCIERNAMGAVQAINAAKLAYLDTGEKRFVGLDYVIKVMYETGLDMSSKYKETSLGGLATNVPVC
>NZ_CP018093.1|WP_066046311.1|988251_989337_+|radical-SAM-protein
MKNQLKWMAWETTRRCNLKCVHCRSSSECEVLGHPDFSTEEGFRIIDSIAAFANPVLVLSGGEPLLRTDIFELAQYGANKGLRMALATNGSLVTDEICEKIKSSSISIVSLSIDGATAATHDDFRGQKGAFEATVNAAKLFKKHRIPFLINSSFTKRNQHEIKDVYKLAKSLEATAWYLFMIVPTGRGEELMQELIDIDDYQDILNWHYDMEADEQDMLVRPTCAPHYYRIRFERNKEDSAKVRSRALSFGTGGGKGCIAGQSICLLDVDGNVYPCSYLPVSAGNVKEKSFVEIWQNSDVMNHMRDFSAYEGKCGACEFIKICGGCRARAYNIHGSYLAEEPFCNHMPIRMRNTEEKQSNE
>NZ_CP018093.1|WP_066046310.1|989329_989578_+|glutaredoxin
MNNFKSIVLYRMVTPEKVCPYGLKAKALFEQKGWSFEDNHLKTRAETDAFKAKYNLQTTPLIFIDGKQIGGYSDLLEFLGEK
>NZ_CP018093.1|WP_066046309.1|989574_990024_+|acyl-CoA-thioesterase
MNQQLKYFVLSTQVLPEHIDPNKHLNNIVYLQWMQDVAIAHVKANGVFELTESQGLTWFARKHTIEYLSQGFLGDDIAVVTWVESITKISTFRKYHIYRKSDKTLLCKADTLWIMVNAHKAKPAKIPTELVEIFDKYNDFEIDDIKSLI
>NZ_CP018093.1|WP_066046308.1|990039_990393_-|hypothetical-protein
MSKCKTHQNHEHKHQDDCGHTKIKHGDHYDYLHDGHLHHEHNGHYDEHTLEVTEKNPDGCHPIKEDCSKHVHGPNCGHEAVPHGDHIDYIVDGRLHHPHGDHCDDHGPVEVIQNDKK
>NZ_CP018093.1|WP_066046315.1|990606_991575_-|linear-amide-C-N-hydrolase
MFKKILVTPLIILSFLQFSFGCTWFSFENDKGHYFIGRTMEWPGDLNTKITLVPRGYKFADFTTHYGFVGMSHNGNFSDGMNEYGLAVSALWLSSSKYPDKKDSDYNITMLLPYVLGNTKTVDQAVEFIKKNKFYTSVIPEISDKLEITLHFAISDAKGNSVVVEFINGKTKIYDNKIKVLTNDPTYDQQLELLKKYQGDKFKQDRLIAFDYSPAGRFAKMASFNATKANTPDDLTAVNHAWSMINTVDIPQGSLYWKWVSSQPQFTSYSVVDDLSNRVYYFRTWDNYDIRKVDLSKIDFAKAKYQADTIFGQANYQEFKFK
>NZ_CP018093.1|WP_066046307.1|991671_992424_-|RNA-methyltransferase
MKNLSQKLYKEIKKLHSSQGRKKSPYYVIEGFRCAQEALKRLPQQQIIAILVTEKTDSPNYTLDKKYIITEKDFEALSQTQNPQGILILAEKPKLEELSFDDDFILVLDRIQDPGNIGTILRTAIAVGLKEIILINGTVDPFNPKAIRAGMGAQFSLNFSYLETLAELKNISKLQQRKIWLTTPHQGVSCYAKEFKLANSILVFGEEANGIADFSIGEKTMIPTLSDIESLNVAQAATIYLFEGLRQRLK
>NZ_CP018093.1|WP_066046306.1|992563_994516_+|BCCT-family-transporter
MQREKGAYAPVFYPAIVIASILSLLGILVPTSFANNIQTIQNLILEKFGWAYILAMSFFVCLCLILMFSRFGDIKLGQDHELPEYTNISWFAMLFAAGMGIGLMFYGVAEPLNHFLTPPNLSPDSLETLKQAMNTTFFHWGIQAWSVYAVVGLSLAYFAYRHNLPLLPRSVLYPILGYKIYGVIGHGIDIFAILGTLFGVATSLGFGAMQVSSGMSFLTGIADTQNMQVIYITIIVALATISVALGLDKGIKALSNLNIILAIVLLVFILFLGDTAGLIRDYIQNIGYYLSTIVNQTFNLYAYNQNNQEWLKKWTLFYWGWWIAWSPFVGMFIAKVSKGRTIRQFIIGVLFIPVGFTFLWMTVFGNSAIEIVMTGSAQGLINAANNNIPVALFEFLQHFPFATILLILAVLLIVTFFVTSADSGALVIDILATGNAQTSITPQRIAWSVLSGLLAISLILAGGLQALQSATIISAFPLLFILFLMSISLIKSLRLDYLRIKSIQRHSTVVQYVKADTSWQKRLAAIAYKPSKTQAIEFLQQVVTPAVLEVASEMQKNAINSEVTKDDDDHIQLTINIESGDDFIYSVMLRSYQTKADSDNNRVEVLLGHGGQYYDIIGYSKDQVIADIVNQYDKHLHYLHLAVADKDIIN
>NZ_CP018093.1|WP_066046305.1|994508_994985_-|tryptophan-rich-sensory-protein
MKQFKITKSLSLALFIIVILAIGYFIGMITSINIPSWFTHLESPFFAPPNWVFAPVWTILYIMIAISGWLIFQQGLFKEKAFIVYAIQLGLNFLWSFIFFCWHNIDLALLEMSILWIFVVWNIVVFKHISKLAGYLLVPYLLWISFAWILNLSYAVLN
>NZ_CP018093.1|WP_066046304.1|995114_995969_+|bifunctional-methionine-sulfoxide-reductase-B/A-protein
MLKTKSLTPHEYDIIINKATERPFTGRYNNLDQKGVYICRNCGTPLFRADSKFISTCGWPSYDIHIDNNVKQLPDADGRRTEILCNNCDGHLGHIFHGEGYTKLNTRYCVNSASVDFIPAEDFSNTEEIIVAAGCFWGVEYYMKKLPGVLFAESGYCGGSEPYPDYKKVCQGDTGYLEVVRVIFDTSKVSLQQVLKYFFEIHDFEQVDGQGPDIGEQYKSAIFYYDDKQKQVAEDLIQILAQKGYKVATEIRAMKPYYVAEDYHLDYYMKKGTLPYCHSHKKIF
>NZ_CP018093.1|WP_066046303.1|995965_997168_-|multidrug-effflux-MFS-transporter
MIGIRKGSKYLIFFVVIFVALPPFAIDAYIPAFGNIADFFNVNVNKVAITVSTYVVGFGIGMLFWGALSDRFGRKKILTIGMLIYIASSILCSLTHSFDTLILMRFLQGLGDSPAGVAAMAVLKDCYRGQKLMKMMATMVMVFMLAPIVAPIIGSLIVYLTGNWQDIFHFLTIYGVILLILTLIMPETHPSYKRSKNLVISFKTYLNHFMNIPFIFGALTGGLCFGALFSFITASSNLIIGYFHLGYTQYCILFGLNICGVVFASNYIRRRVTAHNQRKLILNGYYFAIIIIIINILSSYIFDNIYIFIFLNALLTIGLAFVNITTTSKVIDLLKEGFAAGNAVIRLVKFTVAGAAGFFLSFLSISKLMIGIPSQQLGFILVSISLFLLIKNRLFPNQHN

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Crispr_ID: NZ_CP018093_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018093_2

1463910-1464057

Unclear

V-A

Consensus_repeat	Method
AATATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	PILER-CR
ATATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	CRISPRCasFinder

2 spacers

csa3,cas2,cas1,cas4

The CRISPR arrays of NZ_CP018093_2

>merge|NZ_CP018093|2|1463910-1464057|PILER-CR,CRISPRCasFinder
AATTATTTAAGGTTCTTAGACATATTACTAGCTATAACGAAATAAAATATCTACAACAGTAGAAATTATTTAAAGTTCTTAGACATTAATCTAAGTGTTATTAGACATTATATCTACAACAGTAGAAATTATTTAAAGTTCTTAGACC

>NZ_CP018093|2|3|1463910-1464057|PILER-CR
AATTATTTAAGGTTCTTAGACATATTACTAGCTATAACGAAATAAA	ATATCTACAACAGTAGAA
ATTATTTAAAGTTCTTAGACATTAATCTAAGTGTTATTAGACATTA	TATCTACAACAGTAGAAATTATTT
AAAGTTCTTAGACC

>NZ_CP018093|2|2|1463956-1464056|CRISPRCasFinder
ATATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC	ATTAATCTAAGTGTTATTAGACATT
ATATCTACAACAGTAGAAATTATTTAAAGTTCTTAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018093.1\|WP_071794822.1\|1470088_1470619_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|225695
NZ_CP018093.1\|WP_003022238.1\|1458657_1459104_+\|YcgN-family-cysteine-cluster-protein	unknown	unknown	gnl\|CDD\|235356
NZ_CP018093.1\|WP_066046442.1\|1472868_1473759_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179257
NZ_CP018093.1\|WP_066047326.1\|1461243_1462926_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|163244
NZ_CP018093.1\|WP_066047331.1\|1457919_1458432_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018093.1\|WP_071794843.1\|1465456_1465993_-\|type-V-CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|213941
NZ_CP018093.1\|WP_066046440.1\|1471468_1472167_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP018093.1\|WP_066047320.1\|1463530_1463833_-\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP018093.1\|WP_066047313.1\|1464448_1465453_-\|type-V-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|213942
NZ_CP018093.1\|WP_014548730.1\|1457500_1457902_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018093.1\|WP_014548733.1\|1459756_1460506_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_CP018093.1\|WP_071794844.1\|1470624_1471341_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018093.1\|WP_066046443.1\|1474895_1475675_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|237896
NZ_CP018093.1\|WP_014548732.1\|1459155_1459764_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|379309
NZ_CP018093.1\|WP_066047329.1\|1460506_1461193_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293810
NZ_CP018093.1\|WP_066047317.1\|1464195_1464468_-\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP018093.1\|WP_014548747.1\|1473947_1474892_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133030
NZ_CP018093.1\|WP_066047323.1\|1462950_1463469_-\|DUF2892-domain-containing-protein	unknown	unknown	gnl\|CDD\|223680
NZ_CP018093.1\|WP_066047333.1\|1456887_1457313_-\|transcription-antitermination-factor-NusB	unknown	unknown	gnl\|CDD\|273891
NZ_CP018093.1\|WP_066046441.1\|1472236_1472872_+\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199

Protein	Function_ID	Function_description	E-value
NZ_CP018093.1\|WP_071794822.1\|1470088_1470619_-\|N-acetyltransferase	gnl\|CDD\|225695	COG3153, COG3153, Predicted acetyltransferase [General function prediction only].	1.30705e-38
NZ_CP018093.1\|WP_003022238.1\|1458657_1459104_+\|YcgN-family-cysteine-cluster-protein	gnl\|CDD\|235356	PRK05170, PRK05170, YcgN family cysteine cluster protein.	6.61276e-69
NZ_CP018093.1\|WP_066047326.1\|1461243_1462926_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|163244	TIGR03385, Coenzyme_A_disulfide_reductase, CoA-disulfide reductase. Members of this protein family are CoA-disulfide reductase (EC 1.8.1.14), as characterized in Staphylococcus aureus, Pyrococcus horikoshii, and Borrelia burgdorferi, and inferred in several other species on the basis of high levels of CoA and an absence of glutathione as a protective thiol. [Cellular processes, Detoxification].	1.6943e-137
NZ_CP018093.1\|WP_071794843.1\|1465456_1465993_-\|type-V-CRISPR-associated-protein-Cas4	gnl\|CDD\|213941	TIGR04328, hypothetical_protein_HMPREF9709_01098, CRISPR-associated protein Cas4, subtype PREFRAN. Members of this family are the Cas4 protein of a novel CRISPR subtype, PREFRAN, found in Prevotella bryantii B14, Prevotella disiens FB035-09AN, Francisella tularensis subsp. novicida, Francisella philomiragia, Butyrivibrio proteoclasticus B316, Helcococcus kunzii ATCC 51366, etc.	3.85048e-101
NZ_CP018093.1\|WP_066046440.1\|1471468_1472167_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	1.37597e-86
NZ_CP018093.1\|WP_066047320.1\|1463530_1463833_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	7.06377e-18
NZ_CP018093.1\|WP_066047313.1\|1464448_1465453_-\|type-V-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|213942	TIGR04329, hypothetical_protein_SbacW_07302_partial, CRISPR-associated endonuclease Cas1, subtype PREFRAN. Members of this family are the Cas1 endonuclease of a novel CRISPR subtype, PREFRAN, found in Prevotella bryantii B14, Prevotella disiens FB035-09AN, Francisella tularensis subsp. novicida, Francisella philomiragia, Butyrivibrio proteoclasticus B316, Helcococcus kunzii ATCC 51366, etc.	0
NZ_CP018093.1\|WP_014548733.1\|1459756_1460506_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	2.66067e-31
NZ_CP018093.1\|WP_066046442.1\|1472868_1473759_-\|hypothetical-protein	gnl\|CDD\|179257	PRK01231, ppnK, NAD(+) kinase.	5.89308e-90
NZ_CP018093.1\|WP_066046443.1\|1474895_1475675_-\|ABC-transporter-permease	gnl\|CDD\|237896	PRK15066, PRK15066, inner membrane transport permease; Provisional.	8.67e-130
NZ_CP018093.1\|WP_014548732.1\|1459155_1459764_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|379309	pfam13640, 2OG-FeII_Oxy_3, 2OG-Fe(II) oxygenase superfamily. This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.	1.80862e-24
NZ_CP018093.1\|WP_066047329.1\|1460506_1461193_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293810	cd07724, POD-like_MBL-fold, ETHE1 (PDO type I), persulfide dioxygenase A (PDOA, PDO type II) and related proteins; MBL-fold metallo-hydrolase domain. Persulfide dioxygenase (PDO, also known as sulfur dioxygenase, SDO, EC 1.13.11.18) is a non-heme iron-dependent oxygenase which catalyzes the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria. Mutations in ethe1 (the human PDO gene) are responsible for a rare autosomal recessive metabolic disorder called ethylmalonic encephalopathy. Arabidopsis thaliana ETHE1 is essential for embryo and endosperm development. Bacterial ETHE1-type PDOs are also called Type 1 PDOs. Type II PDOs (also called PDOAs), are mainly proteobacterial. These enzymes belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	2.61349e-85
NZ_CP018093.1\|WP_066047317.1\|1464195_1464468_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	4.05897e-13
NZ_CP018093.1\|WP_014548747.1\|1473947_1474892_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133030	cd04187, DPM1_like_bac, Bacterial DPM1_like enzymes are related to eukaryotic DPM1. A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.	2.09775e-81
NZ_CP018093.1\|WP_066047323.1\|1462950_1463469_-\|DUF2892-domain-containing-protein	gnl\|CDD\|223680	COG0607, PspE, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	3.52321e-19
NZ_CP018093.1\|WP_066047333.1\|1456887_1457313_-\|transcription-antitermination-factor-NusB	gnl\|CDD\|273891	TIGR01951, nusB, transcription antitermination factor NusB. A transcription antitermination complex active in many bacteria was designated N-utilization substance (Nus) in E. coli because of its interaction with phage lambda protein N. This model represents NusB. Other components are NusA and NusG. NusE is, in fact, ribosomal protein S10. [Transcription, Transcription factors].	3.42775e-36
NZ_CP018093.1\|WP_066046441.1\|1472236_1472872_+\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.41834e-20

>NZ_CP018093.1|WP_066047320.1|1463530_1463833_-|helix-turn-helix-transcriptional-regulator
MDLMQMKDNASKASSLLKAISHESRLLILCLLLRREMTVGELAEYSSLSQSAFSQHLSVLRNNSLVKCRKEAQNVYYSINDPSVTKILEALYSIYCGDKS
>NZ_CP018093.1|WP_066047323.1|1462950_1463469_-|DUF2892-domain-containing-protein
MNKVEKISVKQFLDLQKKEKVKLIDIRTPAEHSRECIDCAENILVDDIYDADIKSDEVVVLHCQSGNRTNQAASKVVGLNAKKVYLLDGGINAWKQHKQPTQKNVKEPLPIMRQVQIIVGFLVLLGVVLSFTVSQYFAILSGFFGAGLLFAGLTGTCGLAVMLEFLPYNKRR
>NZ_CP018093.1|WP_066047326.1|1461243_1462926_-|FAD-dependent-oxidoreductase
MTKKYLIIGGVAAGASAAARLRRLDESAEIIMFEKGPHVSFSNCGLPYHLGGYIEPAEKLILMTPEKFDKQYNIDARTNSEVIAIDRINKLVTVINCHSGEKYSESYDKLILAVGAKPIVPPFRGLETIEHFILRNVVDVKKIHQAVFDKQKPVKDITVIGAGFIGVEVAENLKERGFNVTIIEMANQIMRPFDYEMAKFLEKELLDNGVKLLLGERVVGFESDKVLLESGKEIKTDLAILAIGVAPDTNFLKEVGINLAKTGHIIVNDNYQTSDENIYAAGDAILVKNALTAQDFNLPLAGPANKQGRLIADHINGHKVVNKGYIGSSIIQIFNYTGAATGLNEAWIKFHNLDIDYEVAYTAPFDRVSIMPNAVNVFTKILFEKNTGKLLGAQVIGRGIVDKRADVFATAIKAGMTVEDLQDLELCYAPPYSTGKDIVNHTGYVANNLLKGDFKQVAFTQVEELLAQNAQIIDVREINETRRGMLKNAKNIPLSEIRTRLAEIDKNKPVYVHCQTGQRSYNVVLLLQQHGYDAYNIAGGYIMILDYYDTIERMTGKKIL
>NZ_CP018093.1|WP_066047329.1|1460506_1461193_-|MBL-fold-metallo-hydrolase
MLFRQLIDRDTYTYTYILGCEQTRQAVIIDSVRFNVNQYLKLLKELDLKLIYAIDTHVHADHVTAAGILRKETGCDIVIGGQSKAECATKKVFDGDILEFGNYQLKALYTPGHTDDSYCFTTENMLFTGDTLLIRGSGRTDFQNGDSYAAYDSIMNKLMTLPGSTIIYPGHDYNGITSSSVAEERQNNPRLKVKSPDEYAKLMADLKLPPPNYIDIAVPANLKCGMEE
>NZ_CP018093.1|WP_014548733.1|1459756_1460506_-|sulfite-exporter-TauE/SafE-family-protein
MFLIVFGFICGIALGLTGGGGSILAVPLLTYGVGLDFHSAVTISLLVVGFTAIFGLVVNYKQHDIHYIAAAVMIVTGVVFAPIGNYISQGLSDKLLMLSFSILMILIGVWSLIKAKLISNSGKSVCKSIGPRCIVALLISGGVVGTLTGFFGVGGGFLIVPALVFITAMPLKRAINTSLLVIFVVSISGFISHYDETSMNWYIASMFIVGSAIGMLLATKVKKSLNDKVLQTIFAVMLVVLGVGLYFIN
>NZ_CP018093.1|WP_014548732.1|1459155_1459764_+|2OG-Fe(II)-oxygenase
MSDLLVLNPFYEKIINDYLNKGFCIIDNWLTTDETSKLRQQLEELYQANYFKKSAVGNRLNENLERSIRNDFIFWLDETKYAQVFFEKINSFIEYINKTCFAGIVNKEFHYAIYPQGSFYKKHIDTFQNDDRRTISVVCYLNQDWQDYFGGQLKLYLKDQTLEIFPTNGKIILFDSKSIEHEVLPVLTENKRFSITGWLKTN
>NZ_CP018093.1|WP_003022238.1|1458657_1459104_+|YcgN-family-cysteine-cluster-protein
MSKWWQQIDLKDMSSEQWESICDRCGLCCLNKLQDDETDEVYYTRVSCKLLDIGKCQCSMYQKRKQLVPECVNLTYKQLKNHAHKWLPNSCSYKLLFEGKDLPDWHHLNTGSTEEMHKQKKSAKHFAISEYELDVDEYLEDFIIKIDN
>NZ_CP018093.1|WP_066047331.1|1457919_1458432_+|hypothetical-protein
MLKKLTPLVYLIVLVLSGCASSGPQQPNLTPLQIQLMQTKVFNVDLRTAFDATVTVMQNLGYIIQDANFDTGIITAKSTQTANFWGDSEYTEATAFIQPYRQSNKNSSIRINFVVYNSMPNPNQGGAPINTSSAILDPQAYENAFAKIQQQIFVQTGISPVLTQPIQQVS
>NZ_CP018093.1|WP_014548730.1|1457500_1457902_+|hypothetical-protein
MKFNIICMLGLAFILNSCVSNTNPENVGFVKTPYTSGNVSLTLKKGVTTKDQVINAFGSPNIVTQNANGESVWTYQTNATVENDASRDGFLTLLITGENTQESGFMQSQKTMTIIITFKGNVVSDYKSLSTNF
>NZ_CP018093.1|WP_066047333.1|1456887_1457313_-|transcription-antitermination-factor-NusB
MKTTARARNNARLYTVQALYQKRVADNTFAELKVQYYADNADRHYTDWDLFYRLIDAVKSNQDTIDKYIQENSNNGVASINYVDYAVLQAAIAELIECLENPYQVIIKEYVEICYSMGTEEGYKFVNAVLQNLAKSIRGEE
>NZ_CP018093.1|WP_066047317.1|1464195_1464468_-|CRISPR-associated-endonuclease-Cas2
MLIVSYDFSNNKVRAKFAKFLEGYGVRLQYSVFELKYSKRMLDLILAEIENNYVPLFTNADSVLIFNAPDKDVIKYGYAIHREQEVVFID
>NZ_CP018093.1|WP_066047313.1|1464448_1465453_-|type-V-CRISPR-associated-endonuclease-Cas1
MFSRNDIESKNIVFVNIFDGVKLSLSLGNIVIKDKETDEVKTKLSVHKVLALFIVGNMTMTSQLLETCKKNAIQLVFMKNSFRPYLCFGDIAEANFLARYKQYSVVEQDISLARIFIASKIHNQHNLVRSLRDKTPEQKEIVKKNKQLIAELENTTSLAELMGVEGNIAKNFFKGFYGHLDNWQGRKPRIKQDPYNVVLDLGYSMLFNFVECFLRLFGFDLYKGFCHQTWYKRKSLVCDFVEPFRCIVDNQVRKSWNLGQFSIEDFGCKNEQFYIKKDKSKDYSKILFAEIISYKLEIFEYVREFYRAFMRDKEIAEYPIFCYETRRVYVNSQL
>NZ_CP018093.1|WP_071794843.1|1465456_1465993_-|type-V-CRISPR-associated-protein-Cas4
MTWLNDFIFCPYSIYLHNIYSNASDTTYYSSSQTKGRQAHKSIDNGIYSTKKDDLIGIDVINHKYGLVGKIDIFHKDKGLLVERKRQIKTIYDGYKYQLYAQYFCLQEMGYDVKAIKFYSMVDNKSYPIEIPTSAELEKFEKHIQTIKQYNPMDNSFRQNIEKCKFCIYANLCDKTDL
>NZ_CP018093.1|WP_071794822.1|1470088_1470619_-|N-acetyltransferase
MHVKILHEKLKDQELIYKLISEAFDTSDEEKLVRLLHTDHQSLISLVAETDDGSIIGQAIISKMTVEKNDKLKIYALAPMCVAPKYQHQGIGSKLIEAIIKEATKNNIDAIFVLGHPSYYPKFGFKPATEYQIKCEYDVPADVFMVLDLSAKLSQLKGQTVYYAEEFGKIFRSIKL
>NZ_CP018093.1|WP_071794844.1|1470624_1471341_-|hypothetical-protein
MKIARYKKGFIKATEYNSKLHFDNIFCPDCGKAKVKIVRKADQEPYFVFVQDQQHDELCPRVAKPIQDQKIKELILSESKKDMSKLNFLVNKNLEKCINLVTKLENNGELKKADELNLMPQKKQQITEKRIREYAKQDIYTINIIDLSDIDTQQPNNKYCLIYGVAGITLADVGDSKKLFFKADQDSRFSLFVVPSQIKYLDFDKGKRAKFAVFGRFKKVGKFINLEIRSTRDLVIRD
>NZ_CP018093.1|WP_066046440.1|1471468_1472167_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MCDKSKENLRQIKSYVQRAGRVTKKQQQALDDYASKYMIEYDQNKSLDFSQIFKNSNDVILEIGFGMGGSLVEMALANPAKNYLGIEVHKAGVGNILYEIEHQNISNLLVMSHDAVEILENMIADQSLSSIQVYFPDPWHKKKHNKRRLVNQTNIDLFAKKLKYGGVFHYASDWLPYAEEVLELLENDSKYRNLYSGFAPRPEWRPLTKFEKRGQNLDYPISDILFERVENK
>NZ_CP018093.1|WP_066046441.1|1472236_1472872_+|LysE-family-translocator
MLIFLTILALQISCLILPGPDFFVTISNSIKFGHKSGIYTASGVASGIFLNTFIVYWFGSFLLYKQPLLFKMLILIGAAYLAYIAFSLYKSIFTKQQLNPNANQHIKNLDNFDKPSNTKFFLNGAFTNLANAKVLVFFSSMLSLVDGLNSFGKVAIWIAIALTTLVWFCIVATFFGNDKLRQVFFRNIKKIEFISAIFITIFVIVILVELF
>NZ_CP018093.1|WP_066046442.1|1472868_1473759_-|hypothetical-protein
MVFKYNKVAIIGKHYKKEVSQMIETLSAYLQQQGLEITIENDTAADTSLVNIATASLKEIALKCDVAIIVGGDGNFLKASRVLALYSNIPVIGINKGKLGFLTTLAADDNALKNDLYAILKGDSSVTKMSMLKCRVDNNLRAPLEASIALNEIAITASRGLMFGLKVFIDGRYAFDQRGDGLIVSTPTGSTAHAMSAGGPILNPNQNSVVLVPICSHSLNSRPLVISDESVIDIYITDYNDPEPVLSIDGRHDTILKASQKVTIQKARKKVTVLHTKDYNYYDTLREKLGWSKVLF
>NZ_CP018093.1|WP_014548747.1|1473947_1474892_+|glycosyltransferase-family-2-protein
MDNKDKLTSIIIPVKDEAEGIEHLFARLMPILEKLPTKYELVFINDGSNDNTLELLLEKQKDIPEIAVVDLSRNFGKEAALFAGFANCNGDAAISIDADLQDPPELILEMVQHWLDGYEVVTAVRENRDTDTSTKKHTAGLFYKVMNRISDTKLTPNAGDYRLLNRAAINAFLELKEKIRFNKGLLTWIGFKEKIVYHAREERAAGQTKWNYWKLFKFSIDGITSFSRAPLEIWSYIGVCVALISFIYGSIIVLKSLLFGIDVPGYPSLVTFILFFSGLQMIGIGMLGSYIGRIFIETKHRPLYIIRRVHRVKE
>NZ_CP018093.1|WP_066046443.1|1474895_1475675_-|ABC-transporter-permease
MNLRDYWITYVTIFNRECKRVFRIWPQTLLPSVITIVLYFLIFGKVVGSRIGTMGDGVTYMQYITPGLIIMAVIQNSYGNVVSSFFGIRFSKAIEELLVSPVSNHVIVLGYISGGIFRGFIVGMFVSVAAFLLGGFATIHNILLVLAGFIFCGALFSLGGLINAIFSQKFDDTTIFPTFILTPLIYLGGVFYNIDNLTGFWHFISSCNPLFYIVDFVRYGFIGVSTVNPYFAFAAIVIFTFLLYYLCWYLLEKGIRLKA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

91476 : 101410

Staphylococcus_phage(28.57%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014547427.1\|91476_93261_+	elongation factor 4	A0A2K9L6L3	Tupanvirus	4.2e-23	42.6
WP_066045100.1\|93276_93699_+	NUDIX domain-containing protein	NA	NA	NA	NA
WP_066045098.1\|93750_94827_+\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
WP_066045096.1\|94844_95834_-	hypothetical protein	NA	NA	NA	NA
WP_156470850.1\|95927_96452_-	peptide deformylase	E3SLL2	Synechococcus_phage	5.5e-16	40.5
WP_066045093.1\|96448_96892_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	8.4e-26	45.7
WP_066045091.1\|96901_98113_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	2.1e-87	44.1
WP_066045090.1\|98105_98711_-	riboflavin synthase	A0A1V0SE20	Indivirus	1.2e-19	35.3
WP_066045088.1\|98703_99771_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	7.4e-52	36.5
WP_014547436.1\|100159_101410_+	sodium:proton antiporter	A0A2H4J428	uncultured_Caudovirales_phage	2.0e-16	36.8

DBSCAN-SWA_2

327125 : 336990

Staphylococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_082810694.1\|327125_328535_+	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	2.8e-30	27.5
WP_071794759.1\|328629_329067_+	endonuclease domain-containing protein	NA	NA	NA	NA
WP_066045706.1\|329069_330188_+	AAA family ATPase	NA	NA	NA	NA
WP_066045703.1\|330190_331204_+	virulence RhuM family protein	Q9JMN3	Wolbachia_phage	8.9e-71	46.2
WP_066045699.1\|331196_332888_+	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	6.8e-100	39.7
WP_066045696.1\|333004_333727_+	SDR family NAD(P)-dependent oxidoreductase	Q56AQ6	Bacillus_thuringiensis_phage	2.3e-33	38.2
WP_014547656.1\|333750_333981_+	TIGR03643 family protein	NA	NA	NA	NA
WP_066045692.1\|333961_335461_+	deoxyribodipyrimidine photo-lyase	A0A1V0SGL1	Hokovirus	4.4e-34	28.1
WP_066045690.1\|335460_336990_+	deoxyribodipyrimidine photolyase	E3T4R9	Cafeteria_roenbergensis_virus	9.9e-58	30.8

DBSCAN-SWA_3

373906 : 382975

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_066045587.1\|373906_374773_+	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	1.4e-29	38.4
WP_066045585.1\|374897_375941_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.4e-55	38.2
WP_066045582.1\|375940_378253_+	phosphoribosylamine--glycine ligase	A0A0M4JBD3	Mollivirus	2.0e-25	30.5
WP_014547703.1\|378256_378835_+	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	1.6e-21	35.8
WP_014547704.1\|378945_379437_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	1.7e-19	40.5
WP_066045579.1\|379439_380537_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_066045576.1\|380533_380887_-	YraN family protein	NA	NA	NA	NA
WP_066045573.1\|380968_382975_-	M3 family metallopeptidase	A0A1V0SID3	Klosneuvirus	7.4e-53	26.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP018093

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection