CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP018024	Alteromonas mediterranea strain CP48 chromosome, complete genome	2 crisprs	cas1,cas3f,cas7f,cas5,cas6f,cas3,DEDDh,WYL,Cas9_archaeal,csa3,DinG	0	7	1	0
NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	2 crisprs	DEDDh,csf2gr7,DinG,cas6e,RT,c2c9_V-U4,Cas14b_CAS-V-F	1	8	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018024_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018024_1

892363-893831

Unclear

I-F

Consensus_repeat	Method
GTTCATGGCCGCACAGGCCACTTAGAAA	PILER-CR
GTTCATGGCCGCACAGGCCACTTAGAAA	CRISPRCasFinder
GTTCATGGCCGCACAGGCCACTTAGAAA	CRT

24 spacers

cas6f,cas5,cas7f,cas3f,cas1,WYL

The CRISPR arrays of NZ_CP018024_1

>merge|NZ_CP018024|1|892363-893831|PILER-CR,CRISPRCasFinder,CRT
GTTCATGGCCGCACAGGCCACTTAGAAAAGCCGGATGAGTAGCCGGTAATGGGGTGTGACGTTCATGGCCGCACAGGCCACTTAGAAATCACTACGGCATTAGAAAAAGTCGTGAAGATGGTTCATGGCCGCACAGGCCACTTAGAAAATTGCTACTGAACAGCAGATTCAAGCGTTTAAGTTCATGGCCGCACAGGCCACTTAGAAATGTATATGTACCCGTTATCGTAACGCTTGCGTGTTCATGGCCGCACAGGCCACTTAGAAATTTCAGTTTAGATAATGCGAATTTCACAACAAGTTCATGGCCGCACAGGCCACTTAGAAAATACACAAGGGTTGGCCGTGCGCGTTTGGTGTGTTCATGGCCGCACAGGCCACTTAGAAATTACGTAAGAACCCAAGCTTTCTATTGTAAACGTTCATGGCCGCACAGGCCACTTAGAAATGTACTTTCTATCGGGGGTAAAGACTCTACGGGTTCATGGCCGCACAGGCCACTTAGAAAAAAACGTTGATTGGTCTGACGCTGACAGTTTAGTTCATGGCCGCACAGGCCACTTAGAAAAGAGTGCGTAGGCAGACCTTCACCTTCGTTATGTTCATGGCCGCACAGGCCACTTAGAAAATGCGTTGCGTCGGTGTTTTCCGCATGTTCATGTTCATGGCCGCACAGGCCACTTAGAAATTTGCGGCACTATCCGGTCTTATCTCGAATATCGTTCATGGCCGCACAGGCCACTTAGAAAGTACAGGGAAATAGCGAGAAGATACGGCGTAGGTTCATGGCCGCACAGGCCACTTAGAAAAAGCTCTTCGCTGTGAAACTCTGCGACTAAGTGTTCATGGCCGCACAGGCCACTTAGAAAAATGCAAAGCAACAGTTCGAAAGCAACTATAAGTTCATGGCCGCACAGGCCACTTAGAAAGAATAGACATAACACATCGGGTTCTCTTGCTCGTTCATGGCCGCACAGGCCACTTAGAAATTACGTAACGACAAATCAGCGCGTCGAAATTCGTTCATGGCCGCACAGGCCACTTAGAAAAGTAGCGCGAAGTAGTATGATTCGAAAGAAGCGTTCATGGCCGCACAGGCCACTTAGAAATTGGATGTTATCAGCATGGAAGAAATCTCCTGGTTCATGGCCGCACAGGCCACTTAGAAATTTCATGGCGGTGAATGGGTCAAAGTTACAGTGTTCATGGCCGCACAGGCCACTTAGAAAGGTGCTGGGTTCACGTTATGGCTTTGTTGAGTGTTCATGGCCGTACAGGCCACTTAGAAAATTACGCACAGTTAGCAAAGTCGGGGATTAAGGTTCATGGCCGCACAGGCCACTTAGAAATAACAAGCGCGATGAATAATCAGGCTACACAGGTTCATGGCCGCACAGGCCACTTAGAAATTTAAGGTATGTTGGAACTGAACGTACTTTCCGTTCATGGCCGCACAGGCCACTTAGAAA

>NZ_CP018024|1|1|892363-893831|PILER-CR
GTTCATGGCCGCACAGGCCACTTAGAAA	AGCCGGATGAGTAGCCGGTAATGGGGTGTGAC
GTTCATGGCCGCACAGGCCACTTAGAAA	TCACTACGGCATTAGAAAAAGTCGTGAAGATG
GTTCATGGCCGCACAGGCCACTTAGAAA	ATTGCTACTGAACAGCAGATTCAAGCGTTTAA
GTTCATGGCCGCACAGGCCACTTAGAAA	TGTATATGTACCCGTTATCGTAACGCTTGCGT
GTTCATGGCCGCACAGGCCACTTAGAAA	TTTCAGTTTAGATAATGCGAATTTCACAACAA
GTTCATGGCCGCACAGGCCACTTAGAAA	ATACACAAGGGTTGGCCGTGCGCGTTTGGTGT
GTTCATGGCCGCACAGGCCACTTAGAAA	TTACGTAAGAACCCAAGCTTTCTATTGTAAAC
GTTCATGGCCGCACAGGCCACTTAGAAA	TGTACTTTCTATCGGGGGTAAAGACTCTACGG
GTTCATGGCCGCACAGGCCACTTAGAAA	AAAACGTTGATTGGTCTGACGCTGACAGTTTA
GTTCATGGCCGCACAGGCCACTTAGAAA	AGAGTGCGTAGGCAGACCTTCACCTTCGTTAT
GTTCATGGCCGCACAGGCCACTTAGAAA	ATGCGTTGCGTCGGTGTTTTCCGCATGTTCAT
GTTCATGGCCGCACAGGCCACTTAGAAA	TTTGCGGCACTATCCGGTCTTATCTCGAATATC
GTTCATGGCCGCACAGGCCACTTAGAAA	GTACAGGGAAATAGCGAGAAGATACGGCGTAG
GTTCATGGCCGCACAGGCCACTTAGAAA	AAGCTCTTCGCTGTGAAACTCTGCGACTAAGT
GTTCATGGCCGCACAGGCCACTTAGAAA	AATGCAAAGCAACAGTTCGAAAGCAACTATAA
GTTCATGGCCGCACAGGCCACTTAGAAA	GAATAGACATAACACATCGGGTTCTCTTGCTC
GTTCATGGCCGCACAGGCCACTTAGAAA	TTACGTAACGACAAATCAGCGCGTCGAAATTC
GTTCATGGCCGCACAGGCCACTTAGAAA	AGTAGCGCGAAGTAGTATGATTCGAAAGAAGC
GTTCATGGCCGCACAGGCCACTTAGAAA	TTGGATGTTATCAGCATGGAAGAAATCTCCTG
GTTCATGGCCGCACAGGCCACTTAGAAA	TTTCATGGCGGTGAATGGGTCAAAGTTACAGT
GTTCATGGCCGCACAGGCCACTTAGAAA	GGTGCTGGGTTCACGTTATGGCTTTGTTGAGT
GTTCATGGCCGTACAGGCCACTTAGAAA	ATTACGCACAGTTAGCAAAGTCGGGGATTAAG
GTTCATGGCCGCACAGGCCACTTAGAAA	TAACAAGCGCGATGAATAATCAGGCTACACAG
GTTCATGGCCGCACAGGCCACTTAGAAA	TTTAAGGTATGTTGGAACTGAACGTACTTTCC
GTTCATGGCCGCACAGGCCACTTAGAAA

>NZ_CP018024|1|1|892363-893831|CRISPRCasFinder
GTTCATGGCCGCACAGGCCACTTAGAAA	AGCCGGATGAGTAGCCGGTAATGGGGTGTGAC
GTTCATGGCCGCACAGGCCACTTAGAAA	TCACTACGGCATTAGAAAAAGTCGTGAAGATG
GTTCATGGCCGCACAGGCCACTTAGAAA	ATTGCTACTGAACAGCAGATTCAAGCGTTTAA
GTTCATGGCCGCACAGGCCACTTAGAAA	TGTATATGTACCCGTTATCGTAACGCTTGCGT
GTTCATGGCCGCACAGGCCACTTAGAAA	TTTCAGTTTAGATAATGCGAATTTCACAACAA
GTTCATGGCCGCACAGGCCACTTAGAAA	ATACACAAGGGTTGGCCGTGCGCGTTTGGTGT
GTTCATGGCCGCACAGGCCACTTAGAAA	TTACGTAAGAACCCAAGCTTTCTATTGTAAAC
GTTCATGGCCGCACAGGCCACTTAGAAA	TGTACTTTCTATCGGGGGTAAAGACTCTACGG
GTTCATGGCCGCACAGGCCACTTAGAAA	AAAACGTTGATTGGTCTGACGCTGACAGTTTA
GTTCATGGCCGCACAGGCCACTTAGAAA	AGAGTGCGTAGGCAGACCTTCACCTTCGTTAT
GTTCATGGCCGCACAGGCCACTTAGAAA	ATGCGTTGCGTCGGTGTTTTCCGCATGTTCAT
GTTCATGGCCGCACAGGCCACTTAGAAA	TTTGCGGCACTATCCGGTCTTATCTCGAATATC
GTTCATGGCCGCACAGGCCACTTAGAAA	GTACAGGGAAATAGCGAGAAGATACGGCGTAG
GTTCATGGCCGCACAGGCCACTTAGAAA	AAGCTCTTCGCTGTGAAACTCTGCGACTAAGT
GTTCATGGCCGCACAGGCCACTTAGAAA	AATGCAAAGCAACAGTTCGAAAGCAACTATAA
GTTCATGGCCGCACAGGCCACTTAGAAA	GAATAGACATAACACATCGGGTTCTCTTGCTC
GTTCATGGCCGCACAGGCCACTTAGAAA	TTACGTAACGACAAATCAGCGCGTCGAAATTC
GTTCATGGCCGCACAGGCCACTTAGAAA	AGTAGCGCGAAGTAGTATGATTCGAAAGAAGC
GTTCATGGCCGCACAGGCCACTTAGAAA	TTGGATGTTATCAGCATGGAAGAAATCTCCTG
GTTCATGGCCGCACAGGCCACTTAGAAA	TTTCATGGCGGTGAATGGGTCAAAGTTACAGT
GTTCATGGCCGCACAGGCCACTTAGAAA	GGTGCTGGGTTCACGTTATGGCTTTGTTGAGT
GTTCATGGCCGTACAGGCCACTTAGAAA	ATTACGCACAGTTAGCAAAGTCGGGGATTAAG
GTTCATGGCCGCACAGGCCACTTAGAAA	TAACAAGCGCGATGAATAATCAGGCTACACAG
GTTCATGGCCGCACAGGCCACTTAGAAA	TTTAAGGTATGTTGGAACTGAACGTACTTTCC
GTTCATGGCCGCACAGGCCACTTAGAAA

>NZ_CP018024|1|1|892363-893831|CRT
GTTCATGGCCGCACAGGCCACTTAGAAA	AGCCGGATGAGTAGCCGGTAATGGGGTGTGAC
GTTCATGGCCGCACAGGCCACTTAGAAA	TCACTACGGCATTAGAAAAAGTCGTGAAGATG
GTTCATGGCCGCACAGGCCACTTAGAAA	ATTGCTACTGAACAGCAGATTCAAGCGTTTAA
GTTCATGGCCGCACAGGCCACTTAGAAA	TGTATATGTACCCGTTATCGTAACGCTTGCGT
GTTCATGGCCGCACAGGCCACTTAGAAA	TTTCAGTTTAGATAATGCGAATTTCACAACAA
GTTCATGGCCGCACAGGCCACTTAGAAA	ATACACAAGGGTTGGCCGTGCGCGTTTGGTGT
GTTCATGGCCGCACAGGCCACTTAGAAA	TTACGTAAGAACCCAAGCTTTCTATTGTAAAC
GTTCATGGCCGCACAGGCCACTTAGAAA	TGTACTTTCTATCGGGGGTAAAGACTCTACGG
GTTCATGGCCGCACAGGCCACTTAGAAA	AAAACGTTGATTGGTCTGACGCTGACAGTTTA
GTTCATGGCCGCACAGGCCACTTAGAAA	AGAGTGCGTAGGCAGACCTTCACCTTCGTTAT
GTTCATGGCCGCACAGGCCACTTAGAAA	ATGCGTTGCGTCGGTGTTTTCCGCATGTTCAT
GTTCATGGCCGCACAGGCCACTTAGAAA	TTTGCGGCACTATCCGGTCTTATCTCGAATATC
GTTCATGGCCGCACAGGCCACTTAGAAA	GTACAGGGAAATAGCGAGAAGATACGGCGTAG
GTTCATGGCCGCACAGGCCACTTAGAAA	AAGCTCTTCGCTGTGAAACTCTGCGACTAAGT
GTTCATGGCCGCACAGGCCACTTAGAAA	AATGCAAAGCAACAGTTCGAAAGCAACTATAA
GTTCATGGCCGCACAGGCCACTTAGAAA	GAATAGACATAACACATCGGGTTCTCTTGCTC
GTTCATGGCCGCACAGGCCACTTAGAAA	TTACGTAACGACAAATCAGCGCGTCGAAATTC
GTTCATGGCCGCACAGGCCACTTAGAAA	AGTAGCGCGAAGTAGTATGATTCGAAAGAAGC
GTTCATGGCCGCACAGGCCACTTAGAAA	TTGGATGTTATCAGCATGGAAGAAATCTCCTG
GTTCATGGCCGCACAGGCCACTTAGAAA	TTTCATGGCGGTGAATGGGTCAAAGTTACAGT
GTTCATGGCCGCACAGGCCACTTAGAAA	GGTGCTGGGTTCACGTTATGGCTTTGTTGAGT
GTTCATGGCCGTACAGGCCACTTAGAAA	ATTACGCACAGTTAGCAAAGTCGGGGATTAAG
GTTCATGGCCGCACAGGCCACTTAGAAA	TAACAAGCGCGATGAATAATCAGGCTACACAG
GTTCATGGCCGCACAGGCCACTTAGAAA	TTTAAGGTATGTTGGAACTGAACGTACTTTCC
GTTCATGGCCGCACAGGCCACTTAGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018024.1\|WP_071958648.1\|880755_881754_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225497
NZ_CP018024.1\|WP_071958662.1\|900069_900561_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|312075
NZ_CP018024.1\|WP_071958658.1\|896741_897503_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|197918
NZ_CP018024.1\|WP_071958651.1\|884779_885607_+\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NZ_CP018024.1\|WP_071958657.1\|894469_895279_+\|metallo-mystery-pair-system-four-Cys-motif-protein	unknown	unknown	gnl\|CDD\|188567
NZ_CP018024.1\|WP_071958660.1\|898083_898794_+\|LrgB-family-protein	unknown	unknown	gnl\|CDD\|377236
NZ_CP018024.1\|WP_071958656.1\|891682_892234_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	cas6f	cd09739_cas6f_CAS-I-F:CAS-IV	gnl\|CDD\|378224
NZ_CP018024.1\|WP_071958659.1\|897677_898091_+\|CidA/LrgA-family-protein	unknown	unknown	gnl\|CDD\|377131
NZ_CP018024.1\|WP_081365697.1\|902429_902993_+\|DUF1566-domain-containing-protein	unknown	unknown	gnl\|CDD\|377878
NZ_CP018024.1\|WP_071950878.1\|896268_896595_+\|DUF3718-domain-containing-protein	unknown	unknown	gnl\|CDD\|378871
NZ_CP018024.1\|WP_071958661.1\|899074_900070_+\|response-regulator	unknown	unknown	gnl\|CDD\|381124
NZ_CP018024.1\|WP_012517421.1\|895578_895908_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018024.1\|WP_071958652.1\|885744_886722_+\|type-I-F-CRISPR-associated-endonuclease-Cas1	cas1	cd09718_cas1_CAS-I-F	gnl\|CDD\|132676
NZ_CP018024.1\|WP_071958653.1\|886718_889649_+\|CRISPR-associated-endonuclease-Cas3''	cas3f	cd09673_cas3f_CAS-I-F	gnl\|CDD\|187804
NZ_CP018024.1\|WP_071958655.1\|890636_891674_+\|hypothetical-protein	cas5	cls000078_cas5_CAS-I-F	unknown
NZ_CP018024.1\|WP_071958654.1\|889652_890627_+\|hypothetical-protein	cas7f	cls000079_cas7f_CAS-I-F	unknown
NZ_CP018024.1\|WP_071958649.1\|881750_882923_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271182
NZ_CP018024.1\|WP_071958663.1\|900651_902427_+\|DUF1566-domain-containing-protein	unknown	unknown	gnl\|CDD\|377878
NZ_CP018024.1\|WP_071958647.1\|880456_880678_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP018024.1\|WP_071958650.1\|882952_884149_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP018024.1\|WP_071958648.1\|880755_881754_+\|hypothetical-protein	gnl\|CDD\|225497	COG2946, COG2946, Putative phage replication protein RstA [DNA replication, recombination, and repair].	3.8593e-23
NZ_CP018024.1\|WP_071958662.1\|900069_900561_+\|PAS-domain-containing-protein	gnl\|CDD\|312075	pfam08448, PAS_4, PAS fold. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.	5.54841e-06
NZ_CP018024.1\|WP_081365697.1\|902429_902993_+\|DUF1566-domain-containing-protein	gnl\|CDD\|377878	pfam07603, DUF1566, Protein of unknown function (DUF1566). These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.	2.80415e-37
NZ_CP018024.1\|WP_071958651.1\|884779_885607_+\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	2.29683e-06
NZ_CP018024.1\|WP_071958657.1\|894469_895279_+\|metallo-mystery-pair-system-four-Cys-motif-protein	gnl\|CDD\|188567	TIGR04052, hypothetical_protein_MettrDRAFT_3899, AZL_007920/MXAN_0976 family protein. Members of this rare protein family regularly occur next to a member of the MXAN_0977 subfamily (TIGR04039) of the di-heme cytochrome c peroxidase/MauG family (pfam03150). MauG itself (TIGR03791) is a protein modification enzyme responsible for the tryptophan tryptophylquinone (TTQ) modification involved in methylamine dehydrogenase activation. All members of this family have a motif of four spaced invariant Cys residues, while additional homologs outside the scope of this family lack the four Cys residues.	1.06195e-37
NZ_CP018024.1\|WP_071958660.1\|898083_898794_+\|LrgB-family-protein	gnl\|CDD\|377236	pfam04172, LrgB, LrgB-like family. The two products of the lrgAB operon are potential membrane proteins, and LrgA and LrgB are both thought to control of murein hydrolase activity and penicillin tolerance.	1.26198e-66
NZ_CP018024.1\|WP_071950878.1\|896268_896595_+\|DUF3718-domain-containing-protein	gnl\|CDD\|378871	pfam12514, DUF3718, Protein of unknown function (DUF3718). This domain family is found in bacteria and viruses, and is approximately 70 amino acids in length. There is a single completely conserved residue C that may be functionally important.	1.67391e-18
NZ_CP018024.1\|WP_071958659.1\|897677_898091_+\|CidA/LrgA-family-protein	gnl\|CDD\|377131	pfam03788, LrgA, LrgA family. This family is uncharacterized. It contains the protein LrgA that has been hypothesized to export murein hydrolases.	1.21094e-20
NZ_CP018024.1\|WP_071958663.1\|900651_902427_+\|DUF1566-domain-containing-protein	gnl\|CDD\|377878	pfam07603, DUF1566, Protein of unknown function (DUF1566). These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.	7.90547e-32
NZ_CP018024.1\|WP_071958658.1\|896741_897503_+\|response-regulator-transcription-factor	gnl\|CDD\|197918	smart00850, LytTR, LytTr DNA-binding domain. This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.	2.28663e-16
NZ_CP018024.1\|WP_071958653.1\|886718_889649_+\|CRISPR-associated-endonuclease-Cas3''	gnl\|CDD\|187804	cd09673, Cas3_Cas2_I-F, CRISPR/Cas system-associated protein Cas3/Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas3/Cas2 fusion; This protein includes both DEAH and HD motifs for helicase and N-terminal domain corresponding to Cas2 RNAse; signature gene for Type I and subtype I-F.	5.04456e-39
NZ_CP018024.1\|WP_071958652.1\|885744_886722_+\|type-I-F-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|132676	TIGR03637, cas1_YPEST, CRISPR-associated endonuclease Cas1, subtype I-F/YPEST. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the YPEST subtype of CRISPR/Cas system.	5.41494e-170
NZ_CP018024.1\|WP_071958661.1\|899074_900070_+\|response-regulator	gnl\|CDD\|381124	cd17593, REC_CheC-like, phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain. This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.11948e-61
NZ_CP018024.1\|WP_071958649.1\|881750_882923_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271182	cd00801, INT_P4_C, Bacteriophage P4 integrase, C-terminal catalytic domain. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. The P4 integrase mediates integrative and excisive site-specific recombination between two sites, called attachment sites, located on the phage genome and the bacterial chromosome. The phage attachment site is often found adjacent to the integrase gene, while the host attachment sites are typically situated near tRNA genes. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.03919e-35
NZ_CP018024.1\|WP_071958656.1\|891682_892234_+\|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4	gnl\|CDD\|378224	pfam09618, Cas_Csy4, CRISPR-associated protein (Cas_Csy4). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family, typified by YPO2462 of Yersinia pestis, is a CRISPR-associated (Cas) family strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy4, for CRISPR/Cas Subtype Ypest protein 4.	4.41562e-66
NZ_CP018024.1\|WP_071958647.1\|880456_880678_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	1.41502e-10

>NZ_CP018024.1|WP_071958656.1|891682_892234_+|type-I-F-CRISPR-associated-endoribonuclease-Cas6/Csy4
MNSYIDVVLKPDAELREAELSSKVFTKFHKGLVALKTDQIGISFPKVRVKLGLVYRLHGNVDKLKELQELNWLGPLIGYCNVSDICPIPEIVQHRNVREIRSNLSSSKLRRLVTRGSIDKQGEKRYKIKMLSNSFDNPYLDILSSSTGQVYRKFFYFGEVQAEPIVGPFDSYGLSKSATIPWF
>NZ_CP018024.1|WP_071958655.1|890636_891674_+|hypothetical-protein
MKIIIEYDSCWRNSFLGGSNNEPVPKKGREFLGSMTNLKKEGNFKFHETTLNTVMGVLNRLIGDQRKLYQARNKLYEQSYYFENLEDKVSFTDKAEKTNEITFIRNMNGSKDQQSFTGMVKADDPVFTSGYSKEFLGVLKLNPSELCDFILDSGFVVNKEVRLSPLYVADLVDEILDMGSVENVNRINEAVELLTNKYSDLVTDKVPTPYIESNGKVKLIRLYSAGLYIQLERLHLRFDMSSSLSPRGSISGFSKRGYNGRRDFMNKYTTGKPKLIWGNPFIKKEKIKGQGEVTSMMTKANGQLEITIDVDRTKGHEIKTLIENAGVSSFYLGKKGLAYVSSIRV
>NZ_CP018024.1|WP_071958654.1|889652_890627_+|hypothetical-protein
MERVTGIKSVDFKIKALGHGVVNWNGPTKLKGEHPLKPYENHTMPKLRGYTNSFENEYDEGTTQKGNSFKVPRLKEAADIDFKKTPLYISQNCIRHHLFKEQSFDLHFAGEKNLEKVLASITGLIRGYVVPASQCKRTSCLLIEDFIDQLGNGNFEQFGKAGERDSSSFFSKTTFGDTEYTSYGSISIEQMQFISLDKKFDRASMIIKEGQGEQVALTVQSFIKSLDPARDPKATFHSNYVRHGTIFEEGECGILLNEEAIHTLVEHTLSRIANLSIRQAKGYMYVDEIIVDYNDSHKMMRIKRDESEIIPEPQSNYAQYFYAK
>NZ_CP018024.1|WP_071958653.1|886718_889649_+|CRISPR-associated-endonuclease-Cas3''
MMVTFVSQCEKNALKKTRRVLDAFANRIGDNTWQILITEEGLLTVKKMLRQTASKSTAVSCHWIRSRSRSELLWIVGSKSKFNSEGVVPVNKTEKEVLMDVTTGKPKKGVLYANTKLQPLAEHLFAVGYIAEQLHQKLFPYSPQFSIVNFIAGCLHDLGKIDPLFQQWVTGPKKKNYIPDDGQHIDTAKFSFEKHPRHNEISLLLCHLMDEASSQYISSKNKESIKHAIYWHHAKPFRKDKASFSTYKGIYKKFNANQKDCTFGEVVERAQILLHQVVNMDKTYRGQDVSILDRAFSKAPFSEDDSDILSSLHVPRYKEYELEESVKSNQANVKPNALNNIARSCVITADRIVSAFSANELHDAIIEQTLGNVVNEILYTESNLASEIDTCLTSFYPNSERSVKQREIAQALTHAPSVAVLAGAAGCGKTKIALEWASLQNVQKIIWVCPRVQVCQGLFYELTSEQYLPNSTIEINTGEFKFHNKWDNPIEADDYFSGDIVITTIDQLLGSVISHTKADTLIDYLNAYVVFDEFHEYVNMPAFNLLLAELVTAKKMQEKSNVLLVSATPHYLFVEELLGVEKEDIIEMPSFNTSQYQIDFKVFDDTKFNQANPLFTPQSDTTFVISNMALTAQNSFVANQHDENAVLLHSKFIKSDKRKWFSEVFESFKKGGARKFDVLRSGPIVQASLNISCNAMTTEITNAEDSLQRLGRLDRFGENDGVNVYTLAVPESIANAKGKSPAANFLSKMYTLHSTRKWYQHLLNSLEGKIFTLPEIYSLYKEFHHSEETRTFIESDLVASLKKSVEKINAQVVDPIFIPSKKQKDKGRGKIAKSSLRGDNRFVQLAMIDVSKNEPEYLEQYAYTMPLDDESDIDNLTYSTSAIQGYEQSDKDLLSYMFAKHHNIKGGKKPYKDFVLLNDARDPEYPIYLSYTTNDLLAVGGESSRHPHAIYYAICDKQPIGAISINQINQTTENEE
>NZ_CP018024.1|WP_071958652.1|885744_886722_+|type-I-F-CRISPR-associated-endonuclease-Cas1
MEQFSSMDMKAILHSKRANMFYIEYCRVIQKDGRVLYLTEEKKENLYYNIPIANTTVLLLGTGTSVTQAAMRMLSQAGVLVGFCGGKGTPLYMATEVEWLTSQSEYRPTEYLHGWLRFWFDDEKRLSAAKTLQQARIEYIESTWNRDKDLKNEGFIHGDSSIERALTTFRKRTAYATKTTDLLLTEAQLTKTLYKFAANCVSIEDFKRKHQSTDKANDFLNHGNYLAYGIAASTLWVLGIPHGFAVLHGKTRRGALVFDVADLIKDAIVLPWAFVCAKEDATEQEFRQQILQKFTDHKAMDFMFNTVKNIALQDYSSKKIEGKNL
>NZ_CP018024.1|WP_071958651.1|884779_885607_+|WYL-domain-containing-protein
MELAQRYWMLELLAYWEGKVNTKPLMHAFNISRQSASAIINKYLASNEDTLAYDVTQKAYVVTSAFNPKFINRTVDEYFDWQQVGKTPSFQSREPSTSQIRIQPLSRYVDPSVMRPLLKAMKCKTAVDCEYLSVTNNEPIGRLVYPHSFVKAANRWHVRGFCALRNNYLDFVLSRFRSVEYDGGKATYTENEDVKWNTSVDLILAPDPRLSDIQKQALEKDFNMMNGRITVKARGALVKYTLDDLQIKAKMLEADPQAQQLVCVNYSDIKRWLYE
>NZ_CP018024.1|WP_071958650.1|882952_884149_-|hypothetical-protein
MKRAIYLAGLGQEMYPMSLRDYAQRLSKALDEEDPVASNAYKAEISEMEYSQEGLSVDVVTISKSSEQDEKIVYKLYNFDYAQFLTSNYSDANILKRFLVLCLVLLARFPSLMKSFFDFNFHIKKRSKIQASYFLVIYAVLGMYLLFLIPSVLSVLNGMMNQSGDTVNNSWFGEFLNWIEPVASGIVTSFAITMMLSPASKTIFAKTAIEYLGANQYLSTGEQRQKIQGKLSKLIEEIIEKEGEDIKIELHGYSFGSVIAFDALFPKESPPGTRIKNCITSFCTIGFPLDYIEIYWDNYFSNRVYDGLFLVDWKNIWSETDVLSSSLDNDKTKKLSLIKDEQFWETISFREYSYNIFDSNSVGYLELFMFYGIRAHSMYWDRHSDSKSCLVYLAKNDN
>NZ_CP018024.1|WP_071958649.1|881750_882923_+|tyrosine-type-recombinase/integrase
MKYTKFTDGLLRQASKESFVCRDVIVPQLQFRPAKAHRKVGYFHCLYSEGGVSTSKSLGEYPIVNLQEARKQARKWLVEQHAKRYKLSSVERFTNVGELLNWYQSNIAQQELNSLRTIKNKSHRVESLLRPYLSEVSISDCSSQLLDKAWLRPLNNRFSPSTLRGAFQTLKAAFKQAHGLRYIDENPLLDLNFTMLLPASIKPKKAALAGLPLNEVVKQFQHFSPPDRFLCLLCLGFLTRNTETVMARWRDFDTEKVSWSIPEEHTKTGSALTLPLSTHSLKWLADYKRKQRRYCRSRFLFPVNQGRSSWSSSYAAQRIMNASRGRFTLHDLRKYGSTYLRDSGVDYYLVERLLNHKKTHLDATYIHTTLREPLMGVIDMWHEKINVTCK
>NZ_CP018024.1|WP_071958648.1|880755_881754_+|hypothetical-protein
MNKGVEPKTVAKNHGKLNPEQSPVFIDFLKLRVDDVEAPNPYFEMIALQLRKYDLLISHRQCNRSRGYDCAYKIVTTTQAQNVVGKIEYSERYKRVLLELTGLGCACIEKAESDYVWLQALVAQPAVTIRRIDLALDDENGLYQIEKIDKDYSRGRFNAESGKRPKKENLGNKVEGRTRYIGGPTAYKRGRFYEKGKQLKLSHCRPWMRHEVRFVSNDRDRIPDETIRNRADYFYSAFPRALQKLLGKHSVIPVTERFMREYVSDISTRVASCKRQYGPLIETLTEHHGATATCEMLSRIGRSKVIELPPFVDEVSLADCTDIIALQSGEAI
>NZ_CP018024.1|WP_071958647.1|880456_880678_+|helix-turn-helix-domain-containing-protein
MKVTTQTILLSPQEVAEQLGVTLNTLAVWRCHGSISLSYVKIGRCVRYRAEDVEAFINAHRFYHADKPVNACD
>NZ_CP018024.1|WP_071958657.1|894469_895279_+|metallo-mystery-pair-system-four-Cys-motif-protein
MKMPFRMGAMPSLLLTALLALAGCDVIDFKGREPGEIPFKLVGVDTGACPMIMSIGQDRWNIDYFGFYLSKPEVRIDGKWQRVKFKQTKWQTPNEALLKFHNKCINPDDANSKLVLDVSEELLKLATNLRFTMGLPFDVNHADALTQPSPLNDSSMFSNRRNGHQFLRLDVSKNAKETREWSYHLGSAGCGSESEAAPPETSCAFTNRVEFILPMTQLDTDLDIEISVSNIVAQVDINDAESCVFASSEVSPCDKLIQNLVHRPWIKWQ
>NZ_CP018024.1|WP_012517421.1|895578_895908_+|hypothetical-protein
MTEKPFITSGRNTIIHKIRKLDLLVINGDDHPPIIVTYKGIKQYEGKVPENKRDAKMMDMELVDVTTSDVFGDEKTLVFIQTLNGKEYKIDYSKVGTSMFIKIHQDSIF
>NZ_CP018024.1|WP_071950878.1|896268_896595_+|DUF3718-domain-containing-protein
MFMSRRVTQFALIGISLSLTVSAASAASYPKALENELIAVCKAVKSDSRLQLHRAVKATGLSMRDLHDGLVCNGQDMLTFAVTHNASETAQHIARRINASPSVLTAKR
>NZ_CP018024.1|WP_071958658.1|896741_897503_+|response-regulator-transcription-factor
MIALVFLQSVAMQTSLCTMLEKIGLFRHVYGAHSVGHSLALAEKHPQSIGFYSVSKSSRNLASKHWLAVGDKDEEAMLAFNHNASGFITSPFDEQQVRCTVEHVKAKHYCHKRDVQFNLLVKGLCKQYGVSESALLATLRQQLYKNAQPNVVGIRAESGWCCLNPADIKWIEAAGDYMCVQTLSESYIVRTTLCHLLKRLGEHHFKRCNRSVAVNAKYVMHIEQKLNQQRVVMRGGEAFKITHKYYYQYWHTG
>NZ_CP018024.1|WP_071958659.1|897677_898091_+|CidA/LrgA-family-protein
MRNAINTVVGAVLVFTAYYVGLLIVSLTSLPVPGPLVGLLLLVGVLFAFPQTERQVARAVTFPLKHMSLLFVPAVLGVSIYWSDIKANALAIAIAIIITTSFCLGLTAWLTQALLNTKSTHKTQLNNINKNEGGTND
>NZ_CP018024.1|WP_071958660.1|898083_898794_+|LrgB-family-protein
MIEALNHAFSLRGLFWISVSIVSYIAALWVNRLCKGHPAAHPIVTTALLVSLGLYLTHTSVTAYQHAASLLYWLLGPITVALALPIYRQWQKLKHYGWRLLISIAFGGVLAPIGAWLTLFVLDAPRAMQFTMLAKSITTPLAMETSAQIGGIPALAAVFVIVTGVVGAIMATSMFSLFNIANRQAQGIALGTVAHAVGTAKAIQMGEDVAAMATLGLCVNGIFTAVALPIVFGLFV
>NZ_CP018024.1|WP_071958661.1|899074_900070_+|response-regulator
MFSVLVCDDSLVARKQVAKCLPQDWEVAVHFAKNGQEALTALAEGKGDLLLLDLNMPVLDGYGTLEAIQKQGLKTKVIVVSGDIQPEAHDRVTSLGALDFIRKPVDPKKLAEVLDKYNILHAEEDEVVEASPLDPDIRDCYQEITNIAMGQAGDHLARTMNVFVELPIPNVNLIEVSELHMMLSDIECHEQVTAVCQGFLGPGVSGEALCILSDSSFDDVAKILNVEGEVDDQLQLELLMDAASILIGTCLTGLANQMDINFSQGHPIVLGQHRAITEIIAMNQIKWKRTLAIELSYGLEGYNVQCDLILLFTEESMKMMNSKLAHLLEDF
>NZ_CP018024.1|WP_071958662.1|900069_900561_+|PAS-domain-containing-protein
MSQHLDEFQEFHWMMDMLQTVDVGIVVLDRDFTVKVWNGFMESHSGLLPSEVRDKTLFSLFPAIKQDWFMKKAKPVFDLKTRAFMTWEQRPYLFKFPNYRPITGSESFMYQNITLSPLTSTTGKVDFISMMIYDMTDVAVGKKQLEALQVTMSEAQEAKSSYS
>NZ_CP018024.1|WP_071958663.1|900651_902427_+|DUF1566-domain-containing-protein
MQFNVFSISSYFPRAIVRGLVLFATALLLAACGGGGGGGDGDSGGDGGSGSGDLVINAGPDATVTEGVTYTLSAQVSGGDGTYTYNWSASPSLSITHEDTSDSAASFVAPLVNNATEYTLTVSVNDQSGNTASDFTVITVAPVNIAPEASIDVPEWDGLPANTFPGGVEVIFDGTGSSDSDSASSDGEISDYVWTQTSGTNVITGVDTNLSTLTIVTPIANEEQQLTFQLEVTDSEGATDVETVTITVQSETDTLPVVSAGVSQGVFSGEVVILEGEASTSIPSALPLTYSWERSNNVSSTDSGVTIRSVDDSDALSTFAIAPAVTTSTVVAYTLTVTDANGNSVEDTINVQIRPMPTPLLNDTGFLQQATNNALTEAQQNDFPGQDGQRGADIIEQNGLIEKAGRGKAGFDFTRLNANGDEQDASADTWSCVRDNVTGLVWEVKTDDGAFQDKDYTYSWYSEEVNGGFEGDQTGLNATCLLTSCNTSAYVQAVNAQGLCGFYDWRLPTHDELFSLMHLGIAVDVAIDEDYFPNTGAVTNEPLWYWTSVPSADGVNSDDAQNAWALDFDSGVDNFLNKSSAARVRLVRAGR
>NZ_CP018024.1|WP_081365697.1|902429_902993_+|DUF1566-domain-containing-protein
MNKVVNVKKRNSHVLSSVKTLFASALLACTSLSTFAQECLSDGLETTPNDNFEAVTTSSLLDTTTDLVWKRCAEGQTWDGSTCSGEAVKYTWQQALVLAHEASNDDLLGWRLPNVKELATLTERDCVRPAINSSLFPATPPDDFWTSTPSADDPDRAWVVAFFNASHSIKEKDRFIYVRLVRTYTNE

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Crispr_ID: NZ_CP018024_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018024_2

1766278-1766463

Orphan

Consensus_repeat	Method
TAGCGTGGGTGTCTTTGTAAG	CRT
TGCTCGTTAGCGTGGGTGTCTTTGTAAG	PILER-CR

3 spacers

DEDDh

The CRISPR arrays of NZ_CP018024_2

>merge|NZ_CP018024|2|1766278-1766463|CRT,PILER-CR
TAGTGTGGGTGTCATCGTTAGTTTGTGCATTTAACGTTGGGGCCAATTTTCCATTGTCGTTAGCGTGGGTGTCTTTGTAAGTCGTCGCTACGGCTAATTGTTGTGTGCTGCTATCGTGGGTGTCTTTGTAAGACTTGTTCGACGCCTTCGGAGTTTCTTGCTCGTTAGCATGGGTGTCTTTGTAAG

>NZ_CP018024|2|2|1766278-1766463|CRT
TAGTGTGGGTGTCATCGTTAG	TTTGTGCATTTAACGTTGGGGCCAATTTTCCATTGTCGT
TAGCGTGGGTGTCTTTGTAAG	TCGTCGCTACGGCTAATTGTTGTGTGCTGC
TATCGTGGGTGTCTTTGTAAG	ACTTGTTCGACGCCTTCGGAGTTTCTTGCTCGT
TAGCATGGGTGTCTTTGTAAG

>NZ_CP018024|2|2|1766331-1766463|PILER-CR
TTGTCGTTAGCGTGGGTGTCTTTGTAAG	TCGTCGCTACGGCTAATTGTTGTGTGCTGC
TATCGTGGGTGTCTTTGTAAGACTTGTT	CGACGCCTTCGGAGTTTCTTGCTCGT
TAGCATGGGTGTCTTTGTAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018024.1\|WP_071959059.1\|1755425_1757081_-\|DUF342-domain-containing-protein	unknown	unknown	gnl\|CDD\|377177
NZ_CP018024.1\|WP_071959067.1\|1774979_1779008_+\|ATP-dependent-RNA-helicase-HrpA	unknown	unknown	gnl\|CDD\|182986
NZ_CP018024.1\|WP_071959064.1\|1767876_1770582_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|273804
NZ_CP018024.1\|WP_015067023.1\|1773532_1774879_+\|Na+/H+-antiporter-NhaC-family-protein	unknown	unknown	gnl\|CDD\|224671
NZ_CP018024.1\|WP_071959060.1\|1758871_1762582_+\|response-regulator	unknown	unknown	gnl\|CDD\|236848
NZ_CP018024.1\|WP_012518171.1\|1763909_1764329_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341392
NZ_CP018024.1\|WP_071959058.1\|1752457_1753693_+\|kynureninase	unknown	unknown	gnl\|CDD\|226363
NZ_CP018024.1\|WP_071959068.1\|1780149_1781343_-\|23S-rRNA-methyltransferase	unknown	unknown	gnl\|CDD\|185082
NZ_CP018024.1\|WP_015067025.1\|1779229_1779532_+\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NZ_CP018024.1\|WP_071959069.1\|1781494_1782472_+\|NAD(P)H-quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|176180
NZ_CP018024.1\|WP_071959066.1\|1771983_1773258_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197666
NZ_CP018024.1\|WP_071959065.1\|1771023_1771935_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|366403
NZ_CP018024.1\|WP_071959063.1\|1766688_1767735_-\|acid-phosphatase	unknown	unknown	gnl\|CDD\|277324
NZ_CP018024.1\|WP_015066940.1\|1749303_1749711_-\|MerR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133403
NZ_CP018024.1\|WP_012518181.1\|1779798_1780050_+\|DUF2061-domain-containing-protein	unknown	unknown	gnl\|CDD\|225746
NZ_CP018024.1\|WP_015066941.1\|1750056_1751232_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|180261
NZ_CP018024.1\|WP_071960395.1\|1757207_1758638_-\|exodeoxyribonuclease-I	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|236979
NZ_CP018024.1\|WP_071960394.1\|1753825_1755229_+\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270426
NZ_CP018024.1\|WP_071959061.1\|1762701_1763745_+\|isoaspartyl-peptidase/L-asparaginase	unknown	unknown	gnl\|CDD\|366471
NZ_CP018024.1\|WP_071959057.1\|1751325_1752465_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224423

Protein	Function_ID	Function_description	E-value
NZ_CP018024.1\|WP_071959059.1\|1755425_1757081_-\|DUF342-domain-containing-protein	gnl\|CDD\|377177	pfam03961, FapA, Flagellar Assembly Protein A. Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.	9.35691e-132
NZ_CP018024.1\|WP_071959067.1\|1774979_1779008_+\|ATP-dependent-RNA-helicase-HrpA	gnl\|CDD\|182986	PRK11131, PRK11131, ATP-dependent RNA helicase HrpA; Provisional.	0
NZ_CP018024.1\|WP_071959064.1\|1767876_1770582_-\|TonB-dependent-receptor	gnl\|CDD\|273804	TIGR01782, TonB-dependent_receptor, TonB-dependent receptor. This model represents a family of TonB-dependent outer-membrane receptors which are found mainly in Xanthomonas and Caulobacter. These appear to represent the expansion of a paralogous family in that the 22 X. axonopodis (21 in X. campestris) and 18 C. crescentus sequences are more closely related to each other than any of the many TonB-dependent receptors found in other species. In fact, the Crescentus and Xanthomonas sequences are inseparable on a phylogenetic tree using a PAM-weighted neighbor-joining method, indicating that one of the two genuses may have acquired this set of receptors from the other. The mechanism by which this family is shared between Xanthomonas, a gamma proteobacterial plant pathogen and Caulobacter, an alpha proteobacterial aquatic organism is unclear. [Transport and binding proteins, Porins].	1.65791e-180
NZ_CP018024.1\|WP_015067023.1\|1773532_1774879_+\|Na+/H+-antiporter-NhaC-family-protein	gnl\|CDD\|224671	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion].	1.24971e-69
NZ_CP018024.1\|WP_071959060.1\|1758871_1762582_+\|response-regulator	gnl\|CDD\|236848	PRK11107, PRK11107, hybrid sensory histidine kinase BarA; Provisional.	7.35224e-60
NZ_CP018024.1\|WP_012518171.1\|1763909_1764329_+\|CBS-domain-containing-protein	gnl\|CDD\|341392	cd04629, CBS_pair_bac, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	9.06623e-51
NZ_CP018024.1\|WP_071959058.1\|1752457_1753693_+\|kynureninase	gnl\|CDD\|226363	COG3844, COG3844, Kynureninase [Amino acid transport and metabolism].	4.10017e-150
NZ_CP018024.1\|WP_071959068.1\|1780149_1781343_-\|23S-rRNA-methyltransferase	gnl\|CDD\|185082	PRK15128, PRK15128, 23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI.	0
NZ_CP018024.1\|WP_015067025.1\|1779229_1779532_+\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	7.2413e-13
NZ_CP018024.1\|WP_071959069.1\|1781494_1782472_+\|NAD(P)H-quinone-oxidoreductase	gnl\|CDD\|176180	cd05276, p53_inducible_oxidoreductase, PIG3 p53-inducible quinone oxidoreductase. PIG3 p53-inducible quinone oxidoreductase, a medium chain dehydrogenase/reductase family member, acts in the apoptotic pathway. PIG3 reduces ortho-quinones, but its apoptotic activity has been attributed to oxidative stress generation, since overexpression of PIG3 accumulates reactive oxygen species. PIG3 resembles the MDR family member quinone reductases, which catalyze the reduction of quinone to hydroxyquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.62718e-152
NZ_CP018024.1\|WP_071959066.1\|1771983_1773258_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	4.16538e-12
NZ_CP018024.1\|WP_071959065.1\|1771023_1771935_+\|diguanylate-cyclase	gnl\|CDD\|366403	pfam00990, GGDEF, Diguanylate cyclase, GGDEF domain. This domain is found linked to a wide range of non-homologous domains in a variety of bacteria. It has been shown to be homologous to the adenylyl cyclase catalytic domain and has diguanylate cyclase activity. This observation correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. In the WspR protein of Pseudomonas aeruginosa, the GGDEF domain acts as a diguanylate cyclase, Structure 3bre, when the whole molecule appears to form a tetramer consisting of two symmetrically-related dimers representing a biological unit. The active site is the GGD/EF motif, buried in the structure, and the cyclic dimeric guanosine monophosphate (c-di-GMP) bind to the inhibitory-motif RxxD on the surface. The enzyme thus catalyzes the cyclisation of two guanosine triphosphate (GTP) molecules to one c-di-GMP molecule.	1.83743e-28
NZ_CP018024.1\|WP_071959063.1\|1766688_1767735_-\|acid-phosphatase	gnl\|CDD\|277324	cd07378, MPP_ACP5, Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain. Acid phosphatase 5 (ACP5) removes the mannose 6-phosphate recognition marker from lysosomal proteins. The exact site of dephosphorylation is not clear. Evidence suggests dephosphorylation may take place in a prelysosomal compartment as well as in the lysosome. ACP5 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	4.23989e-68
NZ_CP018024.1\|WP_015066940.1\|1749303_1749711_-\|MerR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|133403	cd04776, HTH_GnyR, Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR. Putative helix-turn-helix (HTH) regulatory protein, GnyR, and other related proteins. GnyR belongs to the gnyRDBHAL cluster, which is involved in acyclic isoprenoid degradation in Pseudomonas aeruginosa. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	1.89936e-57
NZ_CP018024.1\|WP_012518181.1\|1779798_1780050_+\|DUF2061-domain-containing-protein	gnl\|CDD\|225746	COG3205, COG3205, Predicted membrane protein [Function unknown].	1.67334e-22
NZ_CP018024.1\|WP_015066941.1\|1750056_1751232_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0
NZ_CP018024.1\|WP_071960395.1\|1757207_1758638_-\|exodeoxyribonuclease-I	gnl\|CDD\|236979	PRK11779, sbcB, exonuclease I; Provisional.	0
NZ_CP018024.1\|WP_071960394.1\|1753825_1755229_+\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270426	cd13708, PBP2_BvgS_like_1, Putative sensor domain similar to BvgS; the type 2 periplasmic binding protein domain. BvgS is composed of two periplasmic domains homologous to bacterial periplasmic-binding proteins (PBPs), a transmembrane region followed successively by a cytoplasmic PAS (Per/ARNT/SIM), a Histidine-kinase (HK), a receiver and a Histidine phosphotransfer (Hpt) domains. The sensor protein BvgS can autophosphorylate and phosphorylate the response regulator BvgA. The BvgAS phosphorelay controls the expression of virulence factors in response to certain environmental stimuli in Bordetella pertussis. Its close homologs, Escherichia coli EvgS and Klebsiella pneumoniae KvgS, appear to be involved in the transcriptional regulation of drug efflux pumps and in countering free radical stresses and sensing iron limiting conditions, respectively. The periplasmic sensor domain of BvgS belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.97918e-84
NZ_CP018024.1\|WP_071959061.1\|1762701_1763745_+\|isoaspartyl-peptidase/L-asparaginase	gnl\|CDD\|366471	pfam01112, Asparaginase_2, Asparaginase.	1.66391e-136
NZ_CP018024.1\|WP_071959057.1\|1751325_1752465_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	2.69357e-14

>NZ_CP018024.1|WP_012518171.1|1763909_1764329_+|CBS-domain-containing-protein
MESLQVSDYMNTHPVKLNIDMPVAQAVEVLLASGQSGGPVLDTKGRVVGFLSEQDCIAQMIASSYYREQICRVGEIMKTPVVSVKPYMSVIELAQLLLKEKPRVYPVVDDDGVLLGCINRTAVLRAIDVQLNDGYQRAG
>NZ_CP018024.1|WP_071959061.1|1762701_1763745_+|isoaspartyl-peptidase/L-asparaginase
MNLARFSVSSNGWYKTLCTFSVVTAALLATSALAQEPKVAIAIHGGAGTILKSSMTAEQEAAYKNVLSKAVKHGYSLLKKGEKGEVAVVETIKILETSPLFNAGIGAVYTFDGEHELDASIMHGGSKNAGAVAGVKTIRSPIEAALLVMNESPHVMLSGEGAEQYAKENGLEQVKNTVFDTEFRKQALDKVKARMEKASSGYGTQQGNERFGTVGAVVLDRGGNIVAGTSTGGMTAKRYGRIGDSPVIGAGTYADNESCAVSATGHGEFFIRYHVAADICARMKYQGLTLAKAADTVVNDVLVKAGGDGGVIAIDSVGNIAMPFNSAGMYRASIDTEGKVSIAIYKD
>NZ_CP018024.1|WP_071959060.1|1758871_1762582_+|response-regulator
MSSFTPKSTLSEAKGTFGLTVVLAVVLVILVVGLFESNIKAAAKAQTYSALEKSAANAEAAADMQVLQYTNALNFLHQTPPISGIVRATANGNVDPKDSTTLEQWKHRLETIFVAFIENNSEIDQLRVIQANDEGSEVIRVEREGGAVIIASDIDLQTKASRNYFKESVKSNKGEFYISSINLNREYGKLEFPYKAVIRLSLPILSDANERYGFIIMNVNARFLLDQIKQALAENQSLYITDNEGYFTLHPDSDKSFSKDLNPSINWQSEFVQPLKAGRARLSPVEGENTLYSVSRAFTIGGGQQVAPFYLHVSTPKSYVTALINDKRMSVYSVLVAVTIIFTVALLFFYRSNRKNIELAKVRGESVAIVAISKDAIFSVDAFGKVKSWNMAAESLFGIPSQVIINQHFSSFKPLSPLGLEIVLTKGGKQETFTTPYIDGEKNEHKLLITASTIWGDNSQFSGVAVVIRDVTDEHKAKDAIERVNFKLEEKVVSRTKELTKATEEARKASSVKSSFISNISHEMRTPLNGVVGSLSLLKRQPLNDKAEQLVSMMEISCNNLSVLINDVLDLSKIEAGKLDINHQLFEPLTLIESLAKVFAVKAATKGLELIVDTTGLPRVEINSDRHRLNQVLSNLLNNAIKFTEKGHIQLNAALYENDAGLQQLHFSISDTGVGIAPESQPKLFTAFTQADASVATQYGGTGLGLSICKQLTQLLGGDITFKSVVDVGSTFSFYVTLTEKTPDTEASLERALEMESAMLSGISIGVSAGYSPLEENICSLAMHVGADAYVLDSNTDKIEWSTFNAVIVDESSPLINDLDNIWHAQTTEQEACALPVVFILQKIAGAPYQFNHIQPIYLPKPLFRSSFALVQQGIDAALGGYSSSMSELQPSEGNGTSDAAFETVKQTSDPQLSIEDANLLIVDDNLINREVAKGVLESLPGKMFTCCDGEEVIAFLQKCEKKGRRIHSILMDCQMPNMDGYETTRAIREGKAGPLHANVPIIAMTANAMLGEKEKCLEAGMDDFTTKPVIADVLIPKVKQWLIHQTMALKSEDAKRNNEIKSDAPALVDSLLNAINKEASCSGVQEEVSMDDLMSSHSDTNETDTSTSANESNAVSDIPAPDNGKVRESWDKDDAIARIMGDKALFSRVCELYSQSAPDKLKQLKGAVEEQDFAQVQVLSLKLKGMSADIGAVQLKKDFELVWELSKGAQWEKVKALLPSIDDDLNTFIELLAVA
>NZ_CP018024.1|WP_071960395.1|1757207_1758638_-|exodeoxyribonuclease-I
MHTPTFLWHDFETFGTSPQKDLPCQFAAVRTDMDLNVVGKPINIMSAIANDYLPHPEACLVTGITPQQTIRDGSNEADFAAKIYQEMSTPNTCSVGFNSIRFDDEVSRYLFYRNFYDPYSREWRNGNSRWDIIDVARACYALRPDGINWPLREDSSPSFRLEALTAANNIGHDNAHDALNDVYATISLAKLIKEKQPRLFDYALSLRNKHTVMQQIDLSKPSVLLHISSKLPASQGCCTWVMPIAKHPTNSNAFIVIDLSHDIDSVLNDSADEIKQALYAPSDTYDDARERPGLKLIHVNRSPFITTAKAMTEDNAQRLGLDRERCLDNYKKLASTPDLVSKIVAIYEEERHSSELDIDHALYSGGFLSDEDRRWCENVINAKPEDLATFGDKTQHEGLKKLLFRYRARNYPNTLTADEMTKWQYHRQARLTDPDFHGSITLETYMMRLESLAHEHSDNPEKQAILRALYQYAENL
>NZ_CP018024.1|WP_071959059.1|1755425_1757081_-|DUF342-domain-containing-protein
MNGVTISFDKSRTYINLMLNPSEFTSEVDIREIKKQLESGETKRLYVSEKALKSACDTANHYFKTSDGTIVQERIGERKNAEVEFRVPDDGMHANLVLTTPYGGKLPGLSTIKSLAIKNRVIRGVSTKKIESMLSNARRAEPGTVLEETIAKGLPAKNGKNSKFIPLVPNALERVLKPQADDGERVDMRNLGEIICVKVNTPVLRRTAPTQGRSGFDVKGNKLPAVAGEWVDFKMGSGTVVSDGDANLLMSVISGMPKYRDQIMNIDDTFICNGVNVGTGHVNYEGAVLVNGDVTEKMQIKAAGDVTINGFVESAHIEAGGDIIITEGAMGKVNDSQGEFQCKLVASGSIHVQHGQGIDIQCGGNITVGRQLAYSRLRCGGAVIVGQIDKPMGNLFACDIISQDRVEAGTLGAVSGSTLKVDFSPGFNQLLERKDSLDELLRQIRENNLKHKEKIALIQGKKIPKELQHKAAEALELFNNESALLEWLENKANDVKSAKENYQSDIKLIANKRLYPGVSAKLNNRNWRSEREYDRAQIHYDAHQWHYEPLI
>NZ_CP018024.1|WP_071960394.1|1753825_1755229_+|transporter-substrate-binding-domain-containing-protein
MLFLGASVFSAILKAGPEQQAAFTPSEEITYCIDPNWAPYEAIRNGIHVGISAQYMRLIAEIAELEFTLVPTESWQQSLEYVQQGKCKVIPMLNTSDYRKQFLDFSIPYFEAPNVLVAKAGTPMLQGYSGVGNRTVGIVQGYRQVGYISRHYPGLRLKLMPSEEEGLKQLANDEFDVMVGSLMSVNMHINNLKLKDINIVGYAEPFDSLAFGVNKSFGHLVDKLNFAIERIPESRKVEIYKQWNNVQIRYSRNYTVMILSTIIMLIGLLWLISRNRHVGAYKRIINQKNEEISSLQATLLEKNRTLGFLSAHDTITGLYNRNHMIQRAEEEISRFQRFQTTASLIILELTHSHDDGLSLEASSLEEPLKVVATQCLNTVREVDVVSRFSGEQFIILCPQTEVGAAKILADRLLNCVTSHYLLSDNFKVAIGMSELKQTEEFSDWMERTMKALYQSKRHGFGNVSIAP
>NZ_CP018024.1|WP_071959058.1|1752457_1753693_+|kynureninase
MINKVFSAEQLDDKDPLAHKAGAFSLPDNTIYLDGNSLGPLPKSAEKRALEVVQEQWGQGLITSWNKHQWISLPQQVGDKIGELIGAQQGQVICCDSISINLFKVLSAALKMNPGRKVIATTRDNFPTDIYMVQGLLDLLGEEYSIRYVDEASISSQLTDDIAVLMLTQVNFRSGLKLDMKGITEQAHAKGILTLWDLAHSAGAFPVCLDDCNVDFAVGCSYKYLNGGPGAPAFIYVARRHQDSYQQPLSGWMGHSAPFSFSPDYAPDKSVKQNLCGTPGVIGMSILDAALDVFDDVSLKAIDEKSKKLQAFFIAEAKRAGVLEYFGVASPPINCRGSQLALAHDEAYAICQAWIAEGVIADFRAPNILRIGFAPLYLSFADVEKAVTRLAIIMNEKRYENATFQQRQSVT
>NZ_CP018024.1|WP_071959057.1|1751325_1752465_+|alpha/beta-fold-hydrolase
MKNTVHITTFTRALFIALISLQQLAVAQSATFKSGSEPKFNYKDTQDITASNKDTHRINTASKDTHVKNDARPPQSAPEIKQPANSDVKRDDVKNDTHAKTSEIYKDTHDKHNELSGSSKTLTQVPYAALGVLPTREHDELFSYGESPLQSVYVWHGRNTKHDKLAGKAVVFVHGGCWLNAYGYDHASGFYKALADLGMGVFVMEYRRVGDKDGGWPGSLNDVTEAMITSLERIRGNGRYSKVYIAGHSAGGHLAMLAAQKLPQFTQSVSVEKVIGLAAITDINAYAVGANSCQTATAKFMHSMPDENPEAYQAATPNAKLINTPIVLMQGDADSIVPKLHATMAGAKQKIITNGGHFDWLHPDSTSFDALLEVIGEHD
>NZ_CP018024.1|WP_015066941.1|1750056_1751232_+|acetyl-CoA-C-acetyltransferase
MSNESVVIVAAKRTPMGGFNGSLSSLAATKLGEIAIKAACDEVDVSVIDEVIMGCVLPAGLGQSPARQASIGAGLPLSAGVTTINKVCGSGLKAVMMAHDLIKAGSASAVVAGGMESMSNAPYMLPKARTGYRMGHGQVIDHMMLDGLENAYDGKAMGCFAQDTADEENIGRGEMDEFALSSLSKAHEAINSGTFNDEIAPVTVSSRKGDTVVDTDEGPGSARPEKIPTLRPAFKKDGTVTAANSSSISDGAAALVVMSESKAKALGLTPLAKVVAHATNSIEPENFTVAPVGAMEKVLDKAGWTKEDVDLFEINEAFAMVTMLAIKKLGLDESKVNVKGGACALGHPIGASGARILVTLLHALKQSNGRKGIASLCIGGGEGVALAVEML
>NZ_CP018024.1|WP_015066940.1|1749303_1749711_-|MerR-family-DNA-binding-transcriptional-regulator
MNKYDDETTYAIGELAREFDITPRSIRFYEEQGLMSPSRTGQNRVYLNKDRVRLKLILRGKRLGFSLAEVKTLFDMYDTNPNSAVQLEAMLDMTEQKRAVLKQQLEDIQMLMTELDDVEARCREELAELKRGKIA
>NZ_CP018024.1|WP_071959063.1|1766688_1767735_-|acid-phosphatase
MLCFACFFNSAWAQAKQQGPSQIGPTDIAPINSGPTQTAPYSHTYYEKTTIADLSVPDEAVSFLTLGDWGRNGHFYQKHVAKWLDIASYQLDAEFIATTGDNFYDNGIASVDDPYWISSYEAVYHQPHLFINWHPVLGNHDYRGNWQAQIDYSVKSRRWEMPAQYYSKTLALDDGATALLLFIDTSPLNPDYAREAKYQEAYEQGASEQLSWINTMLAQDQYTWKVVIGHHPLYSSGKRYGKTNAIKDVLEPVFHKHNVNLYIAGHEHDLQHNQLAGDELVHVVSGGGSEVRPVGNYEFTQFAKSTGGFVSVSMTAKSIFLNYIDHQGKKVYAHTINKPNTASSSSTL
>NZ_CP018024.1|WP_071959064.1|1767876_1770582_-|TonB-dependent-receptor
MKIKTAYSSLALACVTALGLSIASPVLAADGVIIGSVKDAAKARSYNGAKIKLIELGLVTEAGRDGTFRFPSIPKGTYTLEISYLGEDTVTQTIKVEDNDIARASVEFGTGETIDEILVRGQRSGQASAINQQRVSDRISSIVSADAIGQFPDQNAAESLQRLPGLSIERDQGEGRFVGIRGIDPNLNNVTINGLNIPSPESGVRSVALDVIPSELIQTLEVSKSVTPDMDGDAIGGSVAVKSVSAFDKARDTASVTVQASQNDLRDETSPKVSGTFTKKLSSKWGVAGAVSYFDRDFGSDNVESNGDDELEQRYYTITRERLGSALNIDFRPDFNNQYFLRTLYSEFSDDEYRQGNIFTFDGEDSEIERESKDRFESQSIFTVALGGEHQLDTWEANWQLGYAKSDEDEPDALYYIFKTENNSIDADLNTMRPTVSQNADAMDLSTYEVDEISFEDNYTKDTETSIKFDAARPINVGGYIGELKFGSKYRSREKDRDSSITIFDGDFDDLDAAQFGAASPDYSLDNFGPGLNRGVMRSYFNDNRESLEVDSLNSDVESRGATYVNEEDIFAAYIMGSVDIEKLHLVAGVRYERTDFSTSGMRVELVENEQTDVEEVVNTPWEAERDYDHWLPSVNARYTFSDKLQLRAAYTQTISRPKFEDVAAFQIIESKTEEDDGVFVTEREAEVGNPELQPYEAQNVDLSIEYYPGDVGVISAGLFYKNIDNFVVYADVAGTAGWEGFEEVIQPINGDSADLTGLELSWVKAFNNGFIVSANATFTDSEATTFLDGEKFETQLPNQSDRIGNLTIGYEANDFSVRLATTYKSENFEEIDGDMLRFEDDHVQMDFMARYYINDTMQVYFNGINLGDEPFYNYFDTRSQNAQYEEYGRTFELGFTWQLN
>NZ_CP018024.1|WP_071959065.1|1771023_1771935_+|diguanylate-cyclase
MFSFTNTTQFRHHTRWLAFTVSIVAIAISLALFLGNPKQSADISGLDIVGEGSIVLLTLAWILAALASRPPGKVTSLLVFGLGFFLFSATLDFLDEFLRYPDDAHWISMIESYPAAVGMVVMTAALYQWHLEQRALNLQLRRREWDYRDHDKIDPITQLYRAEYWKEQIQKLQQFNKSAVLAIIDINNFSLFNQQYGYTEGDRYLHEIAQLLVMNLRQHDLACRYAGDRFAILLPDVSPTQADIIIDEIKASIQHLAFRHQLNTNAIYTSARSTHVTLLPNQTLSTVLNAMLTELERPQKSAA
>NZ_CP018024.1|WP_071959066.1|1771983_1773258_+|helix-turn-helix-domain-containing-protein
MEISLSNFTVAASSHADEGGDTFGEKTKPIAELNELGVHAKKHVGVGVSVREGVGADSVGVSVREGVDADSVGVFAGTDVVQSTHDKVIAGYWLVKAVLDVALNRGANKNKLFRGTGIFEDALEPDSLISIKQYHLLLTNVQSQTKGADVSFLLGSALAAQWLHSPMHVLQTCDTLEALLTHLVHQQTFRWCSIPLCQFQCFTTNHKVMLIPQSTVGGAKLAQFVSEVSFASIVALLKGIAKQRVSVSFNFTCARPKNIADFETHLGLKVAFNCPFNSMCIEKHALDESMSTPVIHSPNMVTDKELGRYRLFERYPLISLPDYVRCHVYQTISAHNMGSALPELAEKLAISPATLKRKLKEFNTSYRQLSEEVWRNYALVLLSVHKANNEQAARQMGINDLPNFRRTVKRLTGKTPSELRLSNV
>NZ_CP018024.1|WP_015067023.1|1773532_1774879_+|Na+/H+-antiporter-NhaC-family-protein
MRENNATAPNSVLPNPMGLTPILLFVVLVVVTGVTTNDITAMPILVAFFISAGYGLCLNPKGKKVSFSEKVQTFCQGGGDKNIILLVLIFLLAGAFYAVTIDIGARDATVNMALQFVPSALILPGLFLICCFISFSMGTSMGTITALSPIGAGLATNLGLPIEMALGIVVGGAMFGDNLSFVSDTTIAATRTQGVQLKDKFRANLMVAVPACIVTMALLLMVDVDTSGIVEGGNYDFWRIVPYLCIIAFALTGFNVISVLAVGIASACVVGLVQGSFTMLSMMQSIQKGMGWMQDLAMIAITIGGIVALMHANGGITWLIERLTRRVTSKKGAEFSIAGLVSFLDITTANNTIAIVTAGPIAKDLNEKYGVDPRRTASLLDIFSCSFQGLVPYGAQLLSAAAVVGISPLAITPYCWYPMLIFVFGVAAIWFGFPRFNTPQDDELTQSA
>NZ_CP018024.1|WP_071959067.1|1774979_1779008_+|ATP-dependent-RNA-helicase-HrpA
MSSPIAIKPLYNKLDDCLSADKFRLKRRITLLAQKAKGLGESKGAAPGDKSEASKRKAHGDSTSHSANKGSHKDAQKSAEESLSAQFEKLKADINGSIEKRNWRKANLPKVEYPPLPVSDKKEDIKDAIANNQVVIVAGETGSGKTTQLPKICLELGLGVNGMIAHTQPRRLAARSVATRIAEELNTPLGEKVGFKIRFSDQVSERSYVKLMTDGMLLAEMQQDRFLNQYDTIIIDEAHERSLNIDFLLGYLRQLLDKRPDLKLIITSATIDPERFSKHFNNAPIIEVSGRTYPVEVRYHAPEDFDEDRDQSDAIVHAVDELMREAPGDILVFLSGEREIRDTQDALSKQHYRNTEIVPLYARLSAAEQNRIFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGFARISRYSARSKVQRLPIEPISQASANQRAGRCGRVSDGICIRLYSEDDYLGRPEFTDPEILRTNLASVILQMLALGLGDIAAFPFVQPPDNRNINDGFRLLEEIQAIGKGKGKQKGKMQLTPLGRQIARLPIDPRYARMVIEAERTNALSEVMVIAAGLSIQDPRERPQEKRQQADEKHSEYQDKDSDFISLYNVWVAFREQQNALSQNQLRKWCKQQFINYLRMREWQDIVSQLKKSIAELGFGISKQEADYQSIHQAIASGLLSHMGFKDKEREYMGSRNSRFLIFPGSGLSKSQPKWVMAAELVETSKLFARMVAKIDPAWVEPLAEHVVQRSYSEPHWSKKRGAVIAFEKVTLFGLPIVMKRAKVYSLIDPPICHELFIREALVEGNTKLNYSFLEENQALLEQADEFEQKTRRRDLIVDDEELVSFYAKRIPLEANNDAAFKKWFRQHGSNDSLTFKEEDVYRQQPGQSVANAFPDVWRQGNITLPLRYNFEPNAVDDGVTVVIPLPVLNQVDNIGFDWLVPGLRHDLIVGLIKTLPKRLRRNFVPAPNFAEACLADISETDKNNRPVPLLEAVTDKLRKMTGVIIESDEWNLAQLDKHLKMHFAVVNDNGDDIAKGDDLHALKQQCAGQVKQTFEKAATPELERSNIEQWDFENLPETFVQKVGGFEVQAFPALVEKGDKVDIALIEEADKAQALHKQGVNVLIKNAMPSPLNYLQSKLPNKAKLGLYFNPFGQVKALIDDCIFAGIDAIVTDYCEANKTDIRNKADFEACLDIARANINDKVLEIAKQVEQGLTLAHQCQKQMKGNVPLTMINALGDCKAHLAQLVFPGFVSQIGEARLDDWNRYIKGLARRLEKLPIDPNKDRMHQVTVEKSTKEWEKTCSKYPKGKVPQALLDVRWMIEELRVSLFAQQLGTAYPISAKRITLHLAEY
>NZ_CP018024.1|WP_015067025.1|1779229_1779532_+|PilZ-domain-containing-protein
MLGYDDKRNFFRMMVNSPCQLQITDDESSRTMQAMCKDISATGMSLEVDEPSIEVGTQVSVAIESSSSQIPSLAALATVVRCEPESESSCIIGVEISQMK
>NZ_CP018024.1|WP_012518181.1|1779798_1780050_+|DUF2061-domain-containing-protein
MKKTITFAVMHFAVAFTVAYLLTGSVVVGGAVALVEPAINTVAFYFHEMVWKKIEARKEGATTELASETSAPVRRNQDISFAS
>NZ_CP018024.1|WP_071959068.1|1780149_1781343_-|23S-rRNA-methyltransferase
MSAQVILQPSRDKSLRRKHPWVFESAVAELKGRARIGDTVDVFDDEGDWLGRGAYSPHSKIRVRMWTFKKDESIDNGFFLRRLETALALRKRLFDPNKTNAFRWIASESDGLPGVTIDLYDNVAVVQLLSAGGEKHRSKIVWAITKLMPDVHVYERSDVDVRKKEGLEPVTGVLHGQPPMQVTVKENGINIVVDIESGHKTGFYLDQRDSRAAAAHYAKDADVLNCFSYTGTFSCYALSGGAKSVTNVDVSQPALDLAKHHVAINGYDDKRAHYLNKDVFKALREYHEQNKQFDMVILDPPKFVDNKASLNRAARGYKDINMYGIHAVKSGGLLLTFSCSGLMPADLFQKVVADAALDAGRTIKIIARLNQASDHPIIGSYPEGYYLKGLVCEVTDD
>NZ_CP018024.1|WP_071959069.1|1781494_1782472_+|NAD(P)H-quinone-oxidoreductase
MHYVDFAKGCKPDELTVKEQAGYSLTAGKVKVEVKAFGVNRADTLQRQGNYPPQSGESEILGLEVAGVVSEVASDVSSFKEGDRVCGLVAGGGYATEALVNPAHLMRIPQGMPFFEAAGLTEVFLTAFQCLRTIAHIKPAQRALIHGGASGVGLAATQLCRYWGVHSAVTASSQEKLSLCEKNGAEQLINYKQQAFDEVLKKAWPEGVDMVLDMVGGDYLNRNLQVLKRDGSVVYLAMLAGRYADNLDMAMLLGKRASIIGTTLRNRSDEYKANLIGEFETACIPAFESKELTVNIDTHYSIKDIDKPHGRLENNDTQGKLVVSW

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP018024_1	1.15\|893232\|32\|NZ_CP018024\|PILER-CR,CRISPRCasFinder,CRT	893232-893263	32	MK241539	Alteromonas phage P24, complete genome	8614-8645	0	1.0
NZ_CP018024_1	1.1\|892391\|32\|NZ_CP018024\|PILER-CR,CRISPRCasFinder,CRT	892391-892422	32	NZ_CP018001	Rhizobium sp. Y9 plasmid pY9, complete sequence	364327-364358	7	0.781
NZ_CP018024_1	1.1\|892391\|32\|NZ_CP018024\|PILER-CR,CRISPRCasFinder,CRT	892391-892422	32	CP036360	Agrobacterium sp. 33MFTa1.1 plasmid p_JBx_073812, complete sequence	465466-465497	7	0.781
NZ_CP018024_1	1.3\|892511\|32\|NZ_CP018024\|PILER-CR,CRISPRCasFinder,CRT	892511-892542	32	MG945333	UNVERIFIED: Microviridae sp. isolate 2135-1801, complete genome	4010-4041	8	0.75
NZ_CP018024_1	1.13\|893112\|32\|NZ_CP018024\|PILER-CR,CRISPRCasFinder,CRT	893112-893143	32	MK047639	Phage NGI4, complete genome	24350-24381	8	0.75
NZ_CP018024_1	1.19\|893472\|32\|NZ_CP018024\|PILER-CR,CRISPRCasFinder,CRT	893472-893503	32	MK737937	Raoultella phage RP180, complete genome	21454-21485	8	0.75
NZ_CP018024_1	1.6\|892691\|32\|NZ_CP018024\|PILER-CR,CRISPRCasFinder,CRT	892691-892722	32	NC_001902	Methanobacterium phage psiM2, complete genome	12334-12365	9	0.719
NZ_CP018024_1	1.20\|893532\|32\|NZ_CP018024\|PILER-CR,CRISPRCasFinder,CRT	893532-893563	32	NC_024216	Bacillus phage CAM003, complete genome	147038-147069	10	0.688
NZ_CP018024_1	1.20\|893532\|32\|NZ_CP018024\|PILER-CR,CRISPRCasFinder,CRT	893532-893563	32	KJ489400	Bacillus phage Hoody T, complete genome	146232-146263	10	0.688
NZ_CP018024_1	1.20\|893532\|32\|NZ_CP018024\|PILER-CR,CRISPRCasFinder,CRT	893532-893563	32	MF498901	Bacillus phage Anthony, complete genome	148418-148449	10	0.688

1. spacer 1.15|893232|32|NZ_CP018024|PILER-CR,CRISPRCasFinder,CRT matches to MK241539 (Alteromonas phage P24, complete genome) position: , mismatch: 0, identity: 1.0

aatgcaaagcaacagttcgaaagcaactataa	CRISPR spacer
aatgcaaagcaacagttcgaaagcaactataa	Protospacer
********************************

2. spacer 1.1|892391|32|NZ_CP018024|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018001 (Rhizobium sp. Y9 plasmid pY9, complete sequence) position: , mismatch: 7, identity: 0.781

agccggatgagtagccggtaatgg----ggtgtgac	CRISPR spacer
agccggatgagcagccggtgatgagaacggtg----	Protospacer
***********.*******.***.    ****

3. spacer 1.1|892391|32|NZ_CP018024|PILER-CR,CRISPRCasFinder,CRT matches to CP036360 (Agrobacterium sp. 33MFTa1.1 plasmid p_JBx_073812, complete sequence) position: , mismatch: 7, identity: 0.781

agccggatgagtagccggtaatgg----ggtgtgac	CRISPR spacer
agccggatgagcagccggtgatgagaacggtg----	Protospacer
***********.*******.***.    ****

4. spacer 1.3|892511|32|NZ_CP018024|PILER-CR,CRISPRCasFinder,CRT matches to MG945333 (UNVERIFIED: Microviridae sp. isolate 2135-1801, complete genome) position: , mismatch: 8, identity: 0.75

attgctactgaacagcagattcaagcgtttaa	CRISPR spacer
gtcgctgctgaaaagcagattcaagctgccaa	Protospacer
.*.***.***** *************  ..**

5. spacer 1.13|893112|32|NZ_CP018024|PILER-CR,CRISPRCasFinder,CRT matches to MK047639 (Phage NGI4, complete genome) position: , mismatch: 8, identity: 0.75

gtacagggaaatagcgagaagatacggcgtag	CRISPR spacer
gttagatgaaatagcgagaatgtacggcgttg	Protospacer
**  .. ************* .******** *

6. spacer 1.19|893472|32|NZ_CP018024|PILER-CR,CRISPRCasFinder,CRT matches to MK737937 (Raoultella phage RP180, complete genome) position: , mismatch: 8, identity: 0.75

ttggatgttatcagcatggaagaaatctcctg	CRISPR spacer
agggatgttatcagaatggcagaaattgccgt	Protospacer
  ************ **** ******. **

7. spacer 1.6|892691|32|NZ_CP018024|PILER-CR,CRISPRCasFinder,CRT matches to NC_001902 (Methanobacterium phage psiM2, complete genome) position: , mismatch: 9, identity: 0.719

atacacaagggttggccgtgcgcgtttggtgt	CRISPR spacer
ctacacaaaggttggcggtgcgcgtgtacgcc	Protospacer
 *******.******* ******** *.   .

8. spacer 1.20|893532|32|NZ_CP018024|PILER-CR,CRISPRCasFinder,CRT matches to NC_024216 (Bacillus phage CAM003, complete genome) position: , mismatch: 10, identity: 0.688

tttcatggcggtgaatgggtcaaagttacagt	CRISPR spacer
aaacgaggcggtaaatgggttaaagttactca	Protospacer
   *. ******.*******.********

9. spacer 1.20|893532|32|NZ_CP018024|PILER-CR,CRISPRCasFinder,CRT matches to KJ489400 (Bacillus phage Hoody T, complete genome) position: , mismatch: 10, identity: 0.688

tttcatggcggtgaatgggtcaaagttacagt	CRISPR spacer
aaacgaggcggtaaatgggttaaagttactca	Protospacer
   *. ******.*******.********

10. spacer 1.20|893532|32|NZ_CP018024|PILER-CR,CRISPRCasFinder,CRT matches to MF498901 (Bacillus phage Anthony, complete genome) position: , mismatch: 10, identity: 0.688

tttcatggcggtgaatgggtcaaagttacagt	CRISPR spacer
aaacgaggcggtaaatgggttaaagttactca	Protospacer
   *. ******.*******.********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

922168 : 930834

Streptococcus_phage(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_071958674.1\|922168_923461_-	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	3.8e-135	59.7
WP_012517444.1\|923520_925152_-	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	3.2e-147	50.2
WP_071958675.1\|925288_927880_-	DNA mismatch repair protein MutS	A0A1V0SC35	Catovirus	3.8e-33	21.8
WP_012517446.1\|928041_928581_+	CinA family protein	B5TK85	Pseudomonas_phage	1.0e-25	45.2
WP_012517447.1\|928701_929748_+	recombinase RecA	A0A2D1GPX2	Mycobacterium_phage	2.5e-116	62.8
WP_012517448.1\|930012_930834_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	1.4e-26	33.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP018025

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018025_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018025_1

187640-188036

TypeIV-A

Consensus_repeat	Method
CGGTTCACCCCCACCTACGCGGGGAATAC	CRISPRCasFinder
CGGTTCACCCCCACCTACGCGGGGAATAC	PILER-CR

6 spacers

csf2gr7,DinG,cas6e

The CRISPR arrays of NZ_CP018025_1

>merge|NZ_CP018025|1|187640-188036|CRISPRCasFinder,PILER-CR
CAGATTATCCCCGCCTACGCGGGGAATACTCACATGGCCATATTGCTCGATACTCGATGTTGCGGTTCACCCCCGACTACACGGGGTATACACCTGTTAGTGAGTCAACATTATCAGGTTTTCACGGTTCACCCCCACCTGCGCGGGGAATACAAAGAGCCAATGCCTTCTTCGCACTTTATTGACGGTTCACCCCCACCTACGCGGGGAATACGGTTGGTCTTTGACCAGTCCCTAAGCCCTTGGCGGTTCACCCCCGCCTACGCGGGGAATACTTCTCTGCGGCCGCACACAATAAGTCCATTACCGGTTCACCCCCACCTACGCGGGGAATACCTACTGCTTTAAAAAAAGACTCATCATCAAGTCGGTTCACCCCCGCCTACGCGGGGAATAC

>NZ_CP018025|1|1|187640-188036|CRISPRCasFinder
CAGATTATCCCCGCCTACGCGGGGAATAC	TCACATGGCCATATTGCTCGATACTCGATGTTG
CGGTTCACCCCCGACTACACGGGGTATAC	ACCTGTTAGTGAGTCAACATTATCAGGTTTTCA
CGGTTCACCCCCACCTGCGCGGGGAATAC	AAAGAGCCAATGCCTTCTTCGCACTTTATTGA
CGGTTCACCCCCACCTACGCGGGGAATAC	GGTTGGTCTTTGACCAGTCCCTAAGCCCTTGG
CGGTTCACCCCCGCCTACGCGGGGAATAC	TTCTCTGCGGCCGCACACAATAAGTCCATTAC
CGGTTCACCCCCACCTACGCGGGGAATAC	CTACTGCTTTAAAAAAAGACTCATCATCAAGT
CGGTTCACCCCCGCCTACGCGGGGAATAC

>NZ_CP018025|1|1|187764-188036|PILER-CR
CGGTTCACCCCCACCTGCGCGGGGAATAC	AAAGAGCCAATGCCTTCTTCGCACTTTATTGA
CGGTTCACCCCCACCTACGCGGGGAATAC	GGTTGGTCTTTGACCAGTCCCTAAGCCCTTGG
CGGTTCACCCCCGCCTACGCGGGGAATAC	TTCTCTGCGGCCGCACACAATAAGTCCATTAC
CGGTTCACCCCCACCTACGCGGGGAATAC	CTACTGCTTTAAAAAAAGACTCATCATCAAGT
CGGTTCACCCCCGCCTACGCGGGGAATAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018025.1\|WP_071960721.1\|180833_181403_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960720.1\|180294_180726_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960730.1\|188095_189199_-\|hypothetical-protein	csf2gr7	mkCas0162_csf2gr7_CAS-IV-A	gnl\|CDD\|187814
NZ_CP018025.1\|WP_071960722.1\|181440_182499_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960735.1\|193756_194509_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960731.1\|189218_189944_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960729.1\|186420_187416_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960723.1\|182571_183003_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960724.1\|183346_184396_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960740.1\|195678_196410_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960732.1\|189940_191935_-\|hypothetical-protein	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|224120
NZ_CP018025.1\|WP_155761682.1\|195185_195425_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960733.1\|191927_192521_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl\|CDD\|215025
NZ_CP018025.1\|WP_071960727.1\|185544_185838_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373524
NZ_CP018025.1\|WP_155761718.1\|186060_186420_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|378817
NZ_CP018025.1\|WP_071960725.1\|184461_185157_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960736.1\|194704_194890_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960741.1\|196491_196839_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960726.1\|185168_185426_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960734.1\|192522_193491_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP018025.1\|WP_071960730.1\|188095_189199_-\|hypothetical-protein	gnl\|CDD\|187814	cd09683, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	0.00247109
NZ_CP018025.1\|WP_155761718.1\|186060_186420_+\|ATP-binding-protein	gnl\|CDD\|378817	pfam12128, DUF3584, Protein of unknown function (DUF3584). This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.	1.07277e-10
NZ_CP018025.1\|WP_071960733.1\|191927_192521_-\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|215025	smart01101, CRISPR_assoc, This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	2.75474e-13
NZ_CP018025.1\|WP_071960732.1\|189940_191935_-\|hypothetical-protein	gnl\|CDD\|224120	COG1199, DinG, Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair].	8.76643e-38
NZ_CP018025.1\|WP_071960727.1\|185544_185838_+\|hypothetical-protein	gnl\|CDD\|373524	pfam15065, NCU-G1, Lysosomal transcription factor, NCU-G1. NCU-G1 is a set of highly conserved nuclear proteins rich in proline with a molecular weight of approximately 44 kDa. Especially high levels are detected in human prostate, liver and kidney. NCU-G1 is a dual-function family capable of functioning as a transcription factor as well as a nuclear receptor co-activator by stimulating the transcriptional activity of peroxisome proliferator-activated receptor-alpha (PPAR-alpha).	0.00175355

>NZ_CP018025.1|WP_071960729.1|186420_187416_-|hypothetical-protein
MQSHPSYTAGSTIPVNIEYVSPDEQNVLRVLPKGAWLARNTSDGTVTLSPDANAVSKGEAHPVMSGVTHVMQGPVARVFPGLTTENMHNFADIFKYKVDQIVFPQRYGSTSVEVEQENNALKTVLSDIGATFVASGRGVFPFDPESEAFLEPIQPKSDLLIGYPVNAQRIIATEPPLDNFKVMLINIGIPKNTVDGITSDKGMLPFKVTREDLGALPDELHQDLAHKIRYKAVHATGHMTLGGLTAKSTDELNAEILADALDETLMYASETTIPFYLESALVSLGAPYSEALRSDVNALSYYDNKDFYNSVYTTLKAHTSDDPVPDLGIKY
>NZ_CP018025.1|WP_155761718.1|186060_186420_+|ATP-binding-protein
MYHHHSIFPSVLTKLPCYTHSNLVGGNGAGKTTMLSLIPIFYGVETNQMVSTDSDGASLEIHSKKSAYGAQLAILTKLIDSRDLAIKKVADVTRESRIAIMQERMLAFRLPLTCVRIGC
>NZ_CP018025.1|WP_071960727.1|185544_185838_+|hypothetical-protein
MDKDQYHGYKKIFMGQGMNDKASMRMVANSMGMMGTPLMVMGVILVIVGIPLIALMGAGIFLIISGLVAFFFGRKQKKKKISFLEMIEADEDLPERA
>NZ_CP018025.1|WP_071960726.1|185168_185426_+|hypothetical-protein
MSLPSVHEVEVCPKCGSQNGFYIRSRVSGLVQINYSFDGSGSDNQDMYTPLKHNDQKFAYCQQCESKIGRWDEKAKSIVSTRVRF
>NZ_CP018025.1|WP_071960725.1|184461_185157_+|hypothetical-protein
MAKKAVKVNESENIKRASRVFPNINFKTLGKAVETLFTTSSAQKNHDCIGVAVLVIALLKRRGIDAELCVGEVAWRVDGQASGGVISHVSQQPGVSTVITPESLDPNMDAFPFHAWIKLNEIWYCDFSTYQFQSKMDVLNQDGQNVPVTWKPPFLMFTKSDVSGYLDVANSFSAKVIYYSERQALLDKVNQKSPTADNDDLAALELIYNQIENGELDTVIGPYGNVTLKKD
>NZ_CP018025.1|WP_071960724.1|183346_184396_+|hypothetical-protein
MNTQHQFYLPKNDDELNAYVSSINTAYGDGFDFKVGEKRSEKLRDVICKHLGFTNGYQQLQAHWRKGVNDLLTGDDSTACLIYADAFGPLPVAMVASPVAKILTEKLNELFPCSKKGFYRDDEGEGSQGWGYGVVPSTHALSEYEKCSWVPLYMGSLLIGYTRADMSRHRPILIQGLISGAWLSEKSMLDNLREFFSSPRGKKWGCLIDNSVTPPALSFGKVLSLRMSSMETSVIIPLQGDVEISSDAMSFQTYYAQPTGISVLKNFHVDADRHGTLFVNGIGFDFASIYDFNPKGDGFVVKNAQSNSAYFESEKTSSVEWFGVEGVEIRKDDNVELHNFSDGDLVVLV
>NZ_CP018025.1|WP_071960723.1|182571_183003_-|hypothetical-protein
MNNIHHMQYVKTPSGSIMPTGKCLSEWLEQHPTLIPGDKIAMQDGQLFAYVVEKLTDFDQVNTEVFCKEILQHKELLVLMRREHGKVMFEQFIYAERRVITPEGLFSKQVLVTSFGDPAWVNVSDHAVIVRRDDYEEDKAKYH
>NZ_CP018025.1|WP_071960722.1|181440_182499_-|hypothetical-protein
MPFSYPSGPPMAEKSISRERALHMAHFPQDYVDAHEAGKISIPSGQAGQAWRNFFNNPEKYQRNLTAFGLGGVLAFKGEGMTGYYGGTKIPFHRVASNSVKPDTIAVKEKVASLANAAKEAAINAKLAWKASIPRHGGIHFGSTHEKLHDKYKELQRKADRFDDNGRVTKWVDFEVFCKKHEKFSDPHFLDYAYFKEAYPVHLAHTSQNDFTYVMSNKTSTSDSLEKLRESAEFMFGAAPESLEGSVVSRDGNAFIISNPVVIRNDAGLPLLAYGMNEKESGSLSSDIILQDPSGNGFGLATMDNINDVHLDYPTFDRMKNELQVSNMPEIIAVGENDLSKDVEVTPLRLGR
>NZ_CP018025.1|WP_071960721.1|180833_181403_+|hypothetical-protein
MNWKKSVAIKQFFRAGASEDEACIIGKQIAEHLTGSLKSYLASCGDDADNMHDAIENLKSVNSVSMWEELTAEDPTWCDMPPLKELDERLNDFYDEADRLAIWVDPNAPEFESFELNSVGTIKVGTPLYIKGKNVGRDSYERVLVKDVVNAGKENEEVIINSDSNYYFLTKSYLENKSWAARIDILGHP
>NZ_CP018025.1|WP_071960720.1|180294_180726_+|hypothetical-protein
MTLSLAEQVNKLERKAQNFDDAVDRIMELKIWVDDFENGDTSPHAVINKVKSLIKFYESSSREWLAKIEEQGYQQGGLVKYTNSTFNGKKIIEVKAMKDGEVFAVTDTGLHTIGFTSDGLSYKQGLDSIICDLQDVEGLKLSK
>NZ_CP018025.1|WP_071960730.1|188095_189199_-|hypothetical-protein
MSFFAENKRFSFNITGEVTAQSPISVSRPDDNFVSATGTKDKPRLPRAGAKKDATLPFIPGSSFRGGLRRAARDVIRRLTGEQFDIATSYMLTQGVDITNTMNSQKSAGNIGLEEPLRTLNPLLSLFGAWSLPGHTGVSDLIPTTPGSVFTAGGGVRTNDFIRDPKQIQFLSPEDAEKLQQIILDDSATASEVGELKKEISDLKAKMRDSRDKEVKASIQEEINHIDAMIKVKKESKSGATETIQRPLEGYEAIVPGTVMQHRLPLTMVNAMEMALFLESLATYAKNPVIGGHKNHACGFFSATYAIRHWPEDEDVSREVASIRFNETGFFIEGEIADELQSIRKTFRTAVSDGKFNFKAFLFKHAV
>NZ_CP018025.1|WP_071960731.1|189218_189944_-|hypothetical-protein
MTPFLLQARLITPCVYNRPIRLPGLLYHALLSHYCDEDKAQSALPTLLKENDGVFHGSSLIFGIQPESPVIACFQPSLGIMRNESDFNRSLISPNGRGGKYVSVQLDGGATKTRLGNNQAYHAPFVTFFGYGHSDKITALLNHYVSAVGINATRGAGTLAPNSWDAREISEDHSLIDITGKTGEANRGMPLTPLPEELFKALSPKKYGDHESEMVALRPPYYKNTELKLCAVPEKVSRQLI
>NZ_CP018025.1|WP_071960732.1|189940_191935_-|hypothetical-protein
MSKLKELTSHVFSPDGWLIENGYRHTDVQLAYALSVCDAIEHSKQIHAISADTGVGKTLAYLVVSALYNALNNKRVVIATHSIELLRQIEKDIPIANRITEALTDTTVPFSTRIGKQHYLDPDRIELLYVNLVDEGVELTSKHHELLSWAKTSALTGSGLISDWRQSFGALPIGVTEEAICLTKYSRDGANNAESRSSANAKVAGIVITTHAMMINAAFTEVLGNIGDITFLIDEGDKFENAAELIGNVFIPVKRIASIAKACLSNLKSKKSKSLSALINLAYEYDNALRDMDTGKDIHFKHVGNEQIKQVEHCVSEIVQSMSVALKSSKRSLANLTAFNELQLINDFLSSFNKNISLRGLHFSKKRRNPAFLRFFQSPAAVIHRHLEKGASAIFTSATIRDMGRSEISFSFLASTLMVAESDMGVKASFSPRQYGDLQFFVPDNELPNPYQHGEVNSLWRRYVTDVIRYTQSRYERVLVLATSFDEVDALSILLKGHGAFHKQGTGLAPLVAQWEKNGGILVSPSVWEGFSPRLSDGSQMFSSLVITKLPYSVPCELKLGELRGRLASQGSHYSAEAIYYKNLTQVAMRRFCQGIGRAVRAETDQCDIYICDPRILGNIKLKQGFAKALPKRFEVKLEDACQFDGKVSIEKAAKTMDELEGWV
>NZ_CP018025.1|WP_071960733.1|191927_192521_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MLCVYQESHFLMPNTGQHNANNWHKAIMDVLTNGHHIESLQYLFKTDISPRMPESSLVRVRGLSLPEHCQPVERKQNFTKGVQAAFRLRLCTTRRKKTTVNGKEKTIETFVSEKNDAFHGFLSQKLSSNGFALDSITEIQDTVVERVKRGGTQFFSPRCDVTFLATITDEEAAAIAYVKGIGRNKVFGAGMMEALDV
>NZ_CP018025.1|WP_071960734.1|192522_193491_-|hypothetical-protein
MNGTDFIFETLPDLYEGIETRPSTPSDFCACCQRHVKDTAVPDKSWEGKIYSKTEVHCIPCQVLYHPNQKHFGVEGYRSRQVRYADKETALKANQAITRMGDVKVKDRVTSLSKEGFTLFPTEEDAMAALGEAHEVVVNAGSAVIGKLGMLVGAGMAISANKAIFYAPGKHFDKLTGVGELFIKKQIGGYAMITDVINEFDGSEPFLFIGDFGKKKAELVSNLTLSKGKRSFISCSANGAMRINRNAYLALRQYVLAHFSSAPKSTTADFFKTLRSLASGYTPVSVAQDKLKDLPRIGELLKTLPTCPHERIELTIAVDKGL
>NZ_CP018025.1|WP_071960735.1|193756_194509_+|hypothetical-protein
MFKRIVLTALLVVSSGASKAALVEWHPTFDTTGTSDVVTLGETVEAFNFSSDGTLYEEPRSQDAEINGITFLELTDTFDLDAGERSFLETDVTGATSGDVDYDMLLDTLDYGGGKDSVSFYAGDGYLVEGNAYLVQFWYADIREDLTGSRIMRVGDGNASDALLHNYGEGLGQYIIGTFVADSDSQYFEFQVETNFGNAHLNAYQLRDVTGESTFNLAEGRNLAEVPAPLLPSLACFILMLIRRGKRSLV
>NZ_CP018025.1|WP_071960736.1|194704_194890_+|hypothetical-protein
MNNEQKEYVEKGGENCYKCGSSMIEGGEVSISPGRASQDVWCTECDHEWTTEYTLTSVSES
>NZ_CP018025.1|WP_155761682.1|195185_195425_+|hypothetical-protein
MQEYIEFETNDGIRKVALDRLVLKVSSCSQQGASYHALTMGALESNPQNATLLAPISKLRFDELRGKHPSLPLLRREMD
>NZ_CP018025.1|WP_071960740.1|195678_196410_+|hypothetical-protein
MDCNEKKSQIAFLTEKALDISLNEKELAALIEQTAATINEGGIELFKAFKQNFKDFRPLSIQQLFDGTASPQDERKEVLFSSVLQKITVPPEKSKAHDLPKSLYRGCSLNPLQLRRQNGYCRLDGERSLYKHQMATGRSIYISATSKLSIACEFAMQSERRGGGGHWVYQINPINASSCNDHLSPLRFHAGESEYVFTKHLPFEQIESVAWARNCDELETDFYSIDDAHYLLRELVIKGIAKI
>NZ_CP018025.1|WP_071960741.1|196491_196839_+|hypothetical-protein
MTSYKSFLLFFFAMVLAVLSQLLPVNHDDMHFALKMSFVPCCCAVVLSYLFKMDVNNKESWRREVFIFCASVLGSVLLIKLSVSGIGILSMLFGIAITVLLLTLLLNVVEGATAR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP018025_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018025_2

441876-441993

Orphan

Consensus_repeat	Method
TGGTGACGGTGGTGACGGTGGTGAC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP018025_2

>merge|NZ_CP018025|2|441876-441993|CRISPRCasFinder
AGCTTGCGGTGGCGGCGGTGGCGGCTCGAGTGAACCAACCCCTACAACGCCTACTACTGGTGACGGTGGTGACGGTGGTGACGGTGGTGACGGTGGTGACGGTGGTGACGGTGGTGAC

>NZ_CP018025|2|2|441876-441993|CRISPRCasFinder
AGCTTGCGGTGGCGGCGGTGGCGGC	TCGAGTGAACCAACCCCTACAAC
GCCTACTACTGGTGACGGTGGTGAC	GGTGGTGACGGTGGTGACGG
TGGTGACGGTGGTGACGGTGGTGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018025.1\|WP_071960976.1\|439584_439908_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960981.1\|444783_445689_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NZ_CP018025.1\|WP_071960970.1\|435988_436234_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960982.1\|445755_446286_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960984.1\|447012_447666_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960975.1\|439017_439308_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960983.1\|446323_446929_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960972.1\|436802_437156_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223300
NZ_CP018025.1\|WP_071960986.1\|449000_449801_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368586
NZ_CP018025.1\|WP_071960977.1\|440093_441092_+\|phosphoadenosine-phosphosulfate-reductase-family-protein	unknown	unknown	gnl\|CDD\|238846
NZ_CP018025.1\|WP_071960980.1\|442897_444670_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173820
NZ_CP018025.1\|WP_071960989.1\|451418_452477_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960969.1\|435636_435969_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|372700
NZ_CP018025.1\|WP_071960985.1\|447696_448908_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960974.1\|438316_438817_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960978.1\|441146_441644_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960987.1\|449853_450888_-\|phosphoadenosine-phosphosulfate-reductase-family-protein	unknown	unknown	gnl\|CDD\|238846
NZ_CP018025.1\|WP_071960988.1\|450915_451320_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960971.1\|436247_436445_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018025.1\|WP_071960973.1\|437787_438171_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226197

Protein	Function_ID	Function_description	E-value
NZ_CP018025.1\|WP_071960977.1\|440093_441092_+\|phosphoadenosine-phosphosulfate-reductase-family-protein	gnl\|CDD\|238846	cd01713, PAPS_reductase, This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly modified version of the P loop, the fingerprint peptide of mononucleotide-binding proteins, is present in the active site of the protein, which appears to be a positively charged cleft containing a number of conserved arginine and lysine residues. Although PAPS reductase has no ATPase activity, it shows a striking similarity to the structure of the ATP pyrophosphatase (ATP PPase) domain of GMP synthetase, indicating that both enzyme families have evolved from a common ancestral nucleotide-binding fold. The enzyme uses thioredoxin as an electron donor for the reduction of PAPS to phospho-adenosine-phosphate (PAP) . It is also found in NodP nodulation protein P from Rhizobium meliloti which has ATP sulphurylase activity (sulphate adenylate transferase) .	1.7831e-15
NZ_CP018025.1\|WP_071960980.1\|442897_444670_+\|S8-family-serine-peptidase	gnl\|CDD\|173820	cd07496, Peptidases_S8_13, Peptidase S8 family domain, uncharacterized subfamily 13. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	1.54929e-35
NZ_CP018025.1\|WP_071960981.1\|444783_445689_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	8.45968e-09
NZ_CP018025.1\|WP_071960969.1\|435636_435969_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|372700	pfam13744, HTH_37, Helix-turn-helix domain. Members of this family contains a DNA-binding helix-turn-helix domain.	9.46566e-19
NZ_CP018025.1\|WP_071960973.1\|437787_438171_+\|hypothetical-protein	gnl\|CDD\|226197	COG3671, COG3671, Predicted membrane protein [Function unknown].	1.93991e-17
NZ_CP018025.1\|WP_071960987.1\|449853_450888_-\|phosphoadenosine-phosphosulfate-reductase-family-protein	gnl\|CDD\|238846	cd01713, PAPS_reductase, This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly modified version of the P loop, the fingerprint peptide of mononucleotide-binding proteins, is present in the active site of the protein, which appears to be a positively charged cleft containing a number of conserved arginine and lysine residues. Although PAPS reductase has no ATPase activity, it shows a striking similarity to the structure of the ATP pyrophosphatase (ATP PPase) domain of GMP synthetase, indicating that both enzyme families have evolved from a common ancestral nucleotide-binding fold. The enzyme uses thioredoxin as an electron donor for the reduction of PAPS to phospho-adenosine-phosphate (PAP) . It is also found in NodP nodulation protein P from Rhizobium meliloti which has ATP sulphurylase activity (sulphate adenylate transferase) .	1.42504e-08
NZ_CP018025.1\|WP_071960972.1\|436802_437156_+\|hypothetical-protein	gnl\|CDD\|223300	COG0222, RplL, Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis].	0.00821942
NZ_CP018025.1\|WP_071960986.1\|449000_449801_-\|hypothetical-protein	gnl\|CDD\|368586	pfam05735, TSP_C, Thrombospondin C-terminal region. This region is found at the C-terminus of thrombospondin and related proteins.	3.19419e-05

>NZ_CP018025.1|WP_071960978.1|441146_441644_-|hypothetical-protein
MKFWLSFIILCSAGASFSHVNGENLANAIHIGIVKIREAQAFNSYASTSLSEFNVEIEKRASEKAKIRQTQKNKDNSFDEKSGALAYLEDVLSNATNNEKCKKGLGLLEIRVEKAKQEKDVTLSKAKQWLGYVQKNYCFGILYASDVEKLNADYLLSHYPHLEKG
>NZ_CP018025.1|WP_071960977.1|440093_441092_+|phosphoadenosine-phosphosulfate-reductase-family-protein
MTFQIESNLDFDVKKIEYVVASSGGNDSICLVEFMIRNFEPGTFLVLYNDTGWARKDWPARIDKISDMLREKGVPFVKTLSQGFSNLVKERKGFPMPASKMQFCTQKLKTLPTLSFLTEHDPDCNWTIVTGRRRGESNNRAGLQMYEYDTAIYKGRDVYNPIVTFNEQARDEYILSFGLTPLPHSSMECFPCVCSNKEDLKSLKQWPDKIIEIKELEVSMGHTRNGKPRVMFRPYRCGGGIGIESAIAWAEGARGTKIDVVPKEYQIPEVDYSKYRGDMTSAERVVFWSDIKSQCEKLGYDLSDLPTDLAYDDTTKAGQEFSRQCDGGLCGN
>NZ_CP018025.1|WP_071960976.1|439584_439908_-|hypothetical-protein
MEITSSSFPNKKDIIYRDDFSVHDKLTFRQWCKLFSLDIDQLCILFNVSKPTIYKYIDVSSNVKLRKPIIICCNLMLTFDREDAERYLFQRLSNTSHPWPSRSPIGC
>NZ_CP018025.1|WP_071960975.1|439017_439308_-|hypothetical-protein
MNGTLSVDTSKRTNKNNNGYIGRGGKTVISATKAPRRIPKPQFTDGQVKRPPVTLVKTWLWMYREAKEYELRECARKNIMRTFDSVEDAANYVLKK
>NZ_CP018025.1|WP_071960974.1|438316_438817_-|hypothetical-protein
MDAVLLFSSQHGFWSKERGWVQDISEAEFLPSESSVVVRFKSTQDVNTVRLSSCKNYMPYDFFSMADKLMRLPQHKKMKRLLYRKLNTLTKSRGRPLTLDEKVETYTNVLQSKTDCYAVVGKNGMVTLFSKNDCKPAEKAPVVGPFIQRKRKVQSSNKNKTQRCVA
>NZ_CP018025.1|WP_071960973.1|437787_438171_+|hypothetical-protein
MSDVQEASVVQEENVVPEVLSSKDEAAKLNALIAYGLMVVGMFTGVLWIVGAVWAMVKKSDAQGTVFEDHYTNITKTFWWGLGLSILGFILAFVVVGYFLLLAVWIWSIYKIVKGLAKITSNKAYNS
>NZ_CP018025.1|WP_071960972.1|436802_437156_+|hypothetical-protein
MFGKREVYGIFTCVFASLVIAEYLHGASESLFYNWVLGMMIFAGLFIGELCESRKVITNAYKAKTKEEKARLKKGFDEAILRNDKPAAMKAYRHLKGCGLKEAKAHVESVLSNQPNN
>NZ_CP018025.1|WP_071960971.1|436247_436445_+|hypothetical-protein
MAISQFERAIDEHIAKQQQEDGLSVTVDLTKPVLNETERRAKNIERQLQQKIRTSSGSMALGKLI
>NZ_CP018025.1|WP_071960970.1|435988_436234_+|hypothetical-protein
MKHKDRSSNAAPQVRELGFKAVFAPSDFAACVASGYSNEKLEVIAQEVEQSGDDGSLTYKNNIAEIAKFRESLNDSCNNAR
>NZ_CP018025.1|WP_071960969.1|435636_435969_+|XRE-family-transcriptional-regulator
MALEYTNIFDAITEDGAEASELQTRSDLMIAIRDIVNAKGWDQKQAAAAMGITQPRVSDLVNGRIEKFSIDKLMACLYKIGFRFKPQFENGQLSMSVQSVAQKQNHAAMA
>NZ_CP018025.1|WP_071960980.1|442897_444670_+|S8-family-serine-peptidase
MKNVKRTMMAAAISLVTAQVFAETDNVRLVVSSYKDSLTSEYGSVSQSSATNDVCVNTPALDAQWCVNGEIAKGNGHVVQSSVGQRTLDTRVVELESYGYSASFIAEKLRETGQFDEVVVDVPVTHSYSFTQTQPIKTFQDRYFGDSSEFPSGSNVYGAADLIGTPSGDNVDVLVLDSSFYDTDDVVYHPGSGRSFVTASGETPNDDYRPRDTTGCDGHGLSVAGIVGGTIDNGKGGDGVTNAVNIHPIRVMTCGEGYLSDVSRALLWADDGDGTLFSGDTSEASPYEGKVGIINISLSGYTGSPDSGDDAVTGCPIYMQEAINALKAKGWGITVGAGNNYGAQANEYSPANCEGVITVGALESSGDKASFSNAGDVTVAAHGVSMITSCGENDDNYCTVSGTSMASPLVAGIMAMVKQHTNADMTDIEVMLKATASKSNFGTECETMGCGEGLVDAKALLEAVMQQEDGELNTISFALNEGDECDVTWFVENFGQAVKLCELYSVKFMGGIDLDDTTYKLISVPKGQDLSTEENQTMIGEYESAKVVLRDIDAESFDYGVKMCSAGECGDVFEISTVDALPENKPVQCD
>NZ_CP018025.1|WP_071960981.1|444783_445689_+|glycosyltransferase-family-2-protein
MESMDTTIIIPSACRTERKDCILKAINSVIDSAYCNPRVVFVANGPNVDTELLAYIAKLDRVETKYLKTPSAPNAVMYGVENCVHTKYFGFLDDDDYFLPNAISNRQVALEAQPLYDVAIGQALRSTQGNLSRHMSDKQIESCGRDPFEVIFRQKINWMTSSAGLYRASSIGVSYFKENISYFEWTYLAAKMLTSGVNFLFLNEPDHIILDDDAEGKSLSLSKTQKYAQYESAFMRAIKELPLNKEQRKMVAAKEADHFHDLAEKMRKSGRGKEALVHHLRSLRSPQGFMRYVLSTRHFVM
>NZ_CP018025.1|WP_071960982.1|445755_446286_+|hypothetical-protein
MNNKKIEWTGSNQIEMSEFIGHEDFWHNARGELLIMQEGENIVLPKGGILVKHNSGKVYLPLSKTKYDNEYYSNESELSNALVLIEERINQRLNIPSGDRTAALQAICLLKFWTMPLQNSAESLGFSDYLGGFIRKEFDTDECESSWKIGFLKAHEVDDNKCPESAEYADKLLTSI
>NZ_CP018025.1|WP_071960983.1|446323_446929_+|hypothetical-protein
MVDTLSSDETYFKTLLKLACISSSIKIHNELHGRPERVSRLNEECNPYWLQWDAGRGLVCKLVVHCRSLNVSPTHSHLWPLLNRYYQDLFIEKYEFGRIVEVGKDDFDSLCSAIALNNTVHIDGSKLIPRGVEEASGHYGEEVFWRIWLLKSGTGDNYELHTDSYSLAEKVFSAVNGRCADENDYGESSKKLKYYCRSVYD
>NZ_CP018025.1|WP_071960984.1|447012_447666_+|hypothetical-protein
MKLITLTFALMLSLLPGIAKSEWLVQNYSNTNNLTNDVITIVFTDLGEHDYVKLNWDLYLMDTWDGYDTNYSWSTDYWGFSVDGVAQEWAFHQNPTASADTNPDKTSEQYRAGDSFFDNAPVTSYKGWFRYYNDFNDGWVFEHDSDTLTLTFYAHGLQSPEDESWAIDRLYVATSDDEVHLDGLGNLQDVNTPFQPAILFMFALCPLVNMFKRKSRK
>NZ_CP018025.1|WP_071960985.1|447696_448908_-|hypothetical-protein
MYSELDFYHASTSGIFHKPDHPFYCTPNNNYKLLYERPNLHRCNLNISAPYHTENLSLIESLSQFPEKLELLKNMGFDCVVYSKPGNPLRGASGWGNDASQYLVLDPSIVFNWRAIPTPSKLPAQTVEDKKVFGRFHHNASSYFSEFSAQGEIGVHFGTAKAARARESALKNAIDVRAEFFGPSSLDIERLNSHQKEPSSEAEMLYFLLLKKLSYPRQGLKETVFNMPLDDIKETFAEFKSKPDSSTFQESIERAKLGEHYKVLVDGKSRFETTSKELAEVYVQAYRSCFHKTADILMNNPLELDDLGLWSSQDILKAINPDNETIKAYWEKPEDKRMAFVTHIIKGMGYDGITYKNKVEDEGSVSCIVFDKVQVHQYHERLPEFPSIDCDHAHCDNSMKLKR
>NZ_CP018025.1|WP_071960986.1|449000_449801_-|hypothetical-protein
MKKTAIALGALVAFGSLPLHAETVSDLSGWLVEGDGTWTYDVEQNSWYQSENTPEASYLYDPTGESLGKAISGSITVTGSDDDMIGFVVGYDSGENASSDANYLLMSWKGLNQNGWLEGMRLWHITDAMTLEETRSRGDNVWEPGTNSGMTLLDTATNLGSTGWDKNESYTFDIAYNGSYLAIFVNDELEMSIAPGDAGLETFEEGSFGFYNFSQGGVTYGSVIYDDVEVLIDDEKFANLANAVPFEGAGLATLAALGFAGFRRKK
>NZ_CP018025.1|WP_071960987.1|449853_450888_-|phosphoadenosine-phosphosulfate-reductase-family-protein
MSKESIVVSFSGGLTSGNLSYIIKMHYAQDFEPIFIFANTGCENEETLRFVNQCDIAFGLNVIWVEAVVNPEDGKGITHRVTNFKDAFRSHQYKDPLHPFHAHIMKSGIPNANKPQCSDRLKALVIEDYKKKNGLKGVKHAIGIRQDEMRRVMNKPVFNALASIGIDPHSWRVIPTQKERLHALNEAIDRCLVKPEEKAFKKVISYSSKLAQYNLVYPLSDWIPSTKQDVNDFWEDQPFTLELEDHEGNCMTCWKKSHAKLLLIAAEHPERFEAFDYWEKNYNQVKPNDDGKPRVFFRKHKNAQHIIEEASSLPKEHLRMAVTGARFREDMEDGCSESCESYSI
>NZ_CP018025.1|WP_071960988.1|450915_451320_-|hypothetical-protein
MDDNQNYVIETLAGNPGLEVKLTNYLKELFGVEISKPSLLLIFENCDINILPLELWPESDAPMSLEMQMEIWFFMRFVGRPPAFDNATLSIQSSEADVLASAILHSNWKNNLNDPHQLGFKATEDVSDELDAAQ
>NZ_CP018025.1|WP_071960989.1|451418_452477_-|hypothetical-protein
MLAAIIDKNFDEYCPDNYAFVKALQECPRMLFEDAVGIFPELREMLSERFWDSPDEEDEDTAIENAINERDIKFAITSKDGHTVGAYYEYGGFPTYFTDEGVSFSKLEKEKVSPLSFIKKALKAPHELSQSQSLYVTHGTSVDDASSIMKDGVNMDRCMKGHAGKAFYTSPDFTYANTYGSSIGGETLLFKVSPVARIIKDTDREFENIQDRMGYDDFPELCRSKGIDGILIPSMNLIAFYNPAALDRIGSIESHVLQLTSRVYNVALQAGEHLYNNQGISKDQILNFIIDKVAKETGVKLDANALAGPRLSFDALLERICIQTFELESNHTHQVQYQTPEPAPSAFRAPKI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018025.1	441976-441995	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018025.1	441985-442004	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018025.1	441994-442013	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018024.1	566987-567006	2	0.9

1. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to position: 441976-441995, mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

2. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to position: 441985-442004, mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

3. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to position: 441994-442013, mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

4. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to position: 566987-567006, mismatch: 2, identity: 0.9

ggtggtgacggtggtgacgg	CRISPR spacer
ggaggcgacggtggtgacgg	Protospacer
** **.**************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP018025_1	1.1\|187669\|33\|NZ_CP018025\|CRISPRCasFinder	187669-187701	33	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	187627-187659	0	1.0
NZ_CP018025_1	1.1\|187669\|33\|NZ_CP018025\|CRISPRCasFinder	187669-187701	33	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	187669-187701	0	1.0
NZ_CP018025_1	1.2\|187731\|33\|NZ_CP018025\|CRISPRCasFinder	187731-187763	33	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	187689-187721	0	1.0
NZ_CP018025_1	1.2\|187731\|33\|NZ_CP018025\|CRISPRCasFinder	187731-187763	33	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	187731-187763	0	1.0
NZ_CP018025_1	1.3\|187793\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187793-187824	32	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	187751-187782	0	1.0
NZ_CP018025_1	1.3\|187793\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187793-187824	32	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	187793-187824	0	1.0
NZ_CP018025_1	1.4\|187854\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187854-187885	32	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	187812-187843	0	1.0
NZ_CP018025_1	1.4\|187854\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187854-187885	32	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	187854-187885	0	1.0
NZ_CP018025_1	1.5\|187915\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187915-187946	32	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	187873-187904	0	1.0
NZ_CP018025_1	1.5\|187915\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187915-187946	32	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	187915-187946	0	1.0
NZ_CP018025_1	1.6\|187976\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187976-188007	32	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	187934-187965	0	1.0
NZ_CP018025_1	1.6\|187976\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187976-188007	32	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	187976-188007	0	1.0
NZ_CP018025_2	2.1\|441901\|23\|NZ_CP018025\|CRISPRCasFinder	441901-441923	23	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	448511-448533	0	1.0
NZ_CP018025_2	2.1\|441901\|23\|NZ_CP018025\|CRISPRCasFinder	441901-441923	23	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	441901-441923	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP038854	Pantoea vagans strain LMG 24199 plasmid unnamed1, complete sequence	483990-484009	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	448550-448569	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	448559-448578	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	448568-448587	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	448577-448596	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018028	Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence	448586-448605	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	441940-441959	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	441949-441968	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	441958-441977	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	441967-441986	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	441976-441995	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	441985-442004	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	NZ_CP018025	Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence	441994-442013	0	1.0
NZ_CP018025_2	2.2\|441949\|20\|NZ_CP018025\|CRISPRCasFinder	441949-441968	20	MF098554	Gemmata phage BHS4, partial genome	11259-11278	1	0.95
NZ_CP018025_1	1.3\|187793\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187793-187824	32	NZ_CP012203	Alteromonas macleodii strain HOT1A3 plasmid pAM1A3, complete sequence	129062-129093	3	0.906
NZ_CP018025_1	1.6\|187976\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187976-188007	32	NZ_KX869741	Enterobacter cloacae strain 20130723 plasmid R222, complete sequence	129956-129987	6	0.812
NZ_CP018025_1	1.6\|187976\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187976-188007	32	NZ_CP027678	Salmonella enterica subsp. enterica serovar Corvallis strain 12-01738 plasmid pSE12-01738-1, complete sequence	18798-18829	6	0.812
NZ_CP018025_1	1.6\|187976\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187976-188007	32	NZ_LT994833	Klebsiella pneumoniae isolate CNR341 plasmid CNR341, complete sequence	59063-59094	6	0.812
NZ_CP018025_1	1.6\|187976\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187976-188007	32	NZ_CP043927	Klebsiella quasipneumoniae subsp. quasipneumoniae strain M17277 plasmid p17277A_477, complete sequence	270453-270484	6	0.812
NZ_CP018025_1	1.6\|187976\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187976-188007	32	NZ_LT882699	Enterobacter cloacae isolate Enterobacter cloacae ENCL58 plasmid I, complete sequence	82658-82689	6	0.812
NZ_CP018025_1	1.6\|187976\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187976-188007	32	NZ_CP013139	Pseudoalteromonas sp. Bsw20308 plasmid pPBSW1, complete sequence	788659-788690	6	0.812
NZ_CP018025_1	1.6\|187976\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187976-188007	32	MT647605	Pelagibacter phage Lederberg EXVC029P, complete genome	8982-9013	8	0.75
NZ_CP018025_1	1.6\|187976\|32\|NZ_CP018025\|CRISPRCasFinder,PILER-CR	187976-188007	32	JQ340088	Halocynthia phage JM-2012, complete genome	119835-119866	8	0.75

1. spacer 1.1|187669|33|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 0, identity: 1.0

tcacatggccatattgctcgatactcgatgttg	CRISPR spacer
tcacatggccatattgctcgatactcgatgttg	Protospacer
*********************************

2. spacer 1.1|187669|33|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

tcacatggccatattgctcgatactcgatgttg	CRISPR spacer
tcacatggccatattgctcgatactcgatgttg	Protospacer
*********************************

3. spacer 1.2|187731|33|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 0, identity: 1.0

acctgttagtgagtcaacattatcaggttttca	CRISPR spacer
acctgttagtgagtcaacattatcaggttttca	Protospacer
*********************************

4. spacer 1.2|187731|33|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

acctgttagtgagtcaacattatcaggttttca	CRISPR spacer
acctgttagtgagtcaacattatcaggttttca	Protospacer
*********************************

5. spacer 1.3|187793|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 0, identity: 1.0

aaagagccaatgccttcttcgcactttattga	CRISPR spacer
aaagagccaatgccttcttcgcactttattga	Protospacer
********************************

6. spacer 1.3|187793|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

aaagagccaatgccttcttcgcactttattga	CRISPR spacer
aaagagccaatgccttcttcgcactttattga	Protospacer
********************************

7. spacer 1.4|187854|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggttggtctttgaccagtccctaagcccttgg	CRISPR spacer
ggttggtctttgaccagtccctaagcccttgg	Protospacer
********************************

8. spacer 1.4|187854|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggttggtctttgaccagtccctaagcccttgg	CRISPR spacer
ggttggtctttgaccagtccctaagcccttgg	Protospacer
********************************

9. spacer 1.5|187915|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 0, identity: 1.0

ttctctgcggccgcacacaataagtccattac	CRISPR spacer
ttctctgcggccgcacacaataagtccattac	Protospacer
********************************

10. spacer 1.5|187915|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

ttctctgcggccgcacacaataagtccattac	CRISPR spacer
ttctctgcggccgcacacaataagtccattac	Protospacer
********************************

11. spacer 1.6|187976|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 0, identity: 1.0

ctactgctttaaaaaaagactcatcatcaagt	CRISPR spacer
ctactgctttaaaaaaagactcatcatcaagt	Protospacer
********************************

12. spacer 1.6|187976|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

ctactgctttaaaaaaagactcatcatcaagt	CRISPR spacer
ctactgctttaaaaaaagactcatcatcaagt	Protospacer
********************************

13. spacer 2.1|441901|23|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 0, identity: 1.0

tcgagtgaaccaacccctacaac	CRISPR spacer
tcgagtgaaccaacccctacaac	Protospacer
***********************

14. spacer 2.1|441901|23|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

tcgagtgaaccaacccctacaac	CRISPR spacer
tcgagtgaaccaacccctacaac	Protospacer
***********************

15. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP038854 (Pantoea vagans strain LMG 24199 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

16. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

17. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

18. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

19. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

20. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018028 (Alteromonas mediterranea strain CP49 plasmid MCP49-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

21. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

22. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

23. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

24. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

25. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

26. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

27. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to NZ_CP018025 (Alteromonas mediterranea strain CP48 plasmid pAMCP48-600, complete sequence) position: , mismatch: 0, identity: 1.0

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacgg	Protospacer
********************

28. spacer 2.2|441949|20|NZ_CP018025|CRISPRCasFinder matches to MF098554 (Gemmata phage BHS4, partial genome) position: , mismatch: 1, identity: 0.95

ggtggtgacggtggtgacgg	CRISPR spacer
ggtggtgacggtggtgacga	Protospacer
*******************.

29. spacer 1.3|187793|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_CP012203 (Alteromonas macleodii strain HOT1A3 plasmid pAM1A3, complete sequence) position: , mismatch: 3, identity: 0.906

aaagagccaatgccttcttcgcactttattga	CRISPR spacer
aaagagccaatgccttcttcctactttattaa	Protospacer
******************** .********.*

30. spacer 1.6|187976|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_KX869741 (Enterobacter cloacae strain 20130723 plasmid R222, complete sequence) position: , mismatch: 6, identity: 0.812

ctactgctttaaaaaaagactcatcatcaagt	CRISPR spacer
ggtatgctttaaaaaaagactcatagtcaagt	Protospacer
    ******************** .******

31. spacer 1.6|187976|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_CP027678 (Salmonella enterica subsp. enterica serovar Corvallis strain 12-01738 plasmid pSE12-01738-1, complete sequence) position: , mismatch: 6, identity: 0.812

ctactgctttaaaaaaagactcatcatcaagt	CRISPR spacer
ggtatgctttaaaaaaagactcatagtcaagt	Protospacer
    ******************** .******

32. spacer 1.6|187976|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_LT994833 (Klebsiella pneumoniae isolate CNR341 plasmid CNR341, complete sequence) position: , mismatch: 6, identity: 0.812

ctactgctttaaaaaaagactcatcatcaagt	CRISPR spacer
ggtatgctttaaaaaaagactcatagtcaagt	Protospacer
    ******************** .******

33. spacer 1.6|187976|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_CP043927 (Klebsiella quasipneumoniae subsp. quasipneumoniae strain M17277 plasmid p17277A_477, complete sequence) position: , mismatch: 6, identity: 0.812

ctactgctttaaaaaaagactcatcatcaagt	CRISPR spacer
ggtatgctttaaaaaaagactcatagtcaagt	Protospacer
    ******************** .******

34. spacer 1.6|187976|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_LT882699 (Enterobacter cloacae isolate Enterobacter cloacae ENCL58 plasmid I, complete sequence) position: , mismatch: 6, identity: 0.812

ctactgctttaaaaaaagactcatcatcaagt	CRISPR spacer
ggtatgctttaaaaaaagactcatagtcaagt	Protospacer
    ******************** .******

35. spacer 1.6|187976|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to NZ_CP013139 (Pseudoalteromonas sp. Bsw20308 plasmid pPBSW1, complete sequence) position: , mismatch: 6, identity: 0.812

ctact-gctttaaaaaaagactcatcatcaagt	CRISPR spacer
-tattggctttaaaaaaaggctcatcatccaaa	Protospacer
 **.* *************.********* *.

36. spacer 1.6|187976|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to MT647605 (Pelagibacter phage Lederberg EXVC029P, complete genome) position: , mismatch: 8, identity: 0.75

ctactgctttaaaaaaagactcatcatcaagt	CRISPR spacer
atgtatctttaacaaaagaatcatcatcaact	Protospacer
 *..  ****** ****** ********** *

37. spacer 1.6|187976|32|NZ_CP018025|CRISPRCasFinder,PILER-CR matches to JQ340088 (Halocynthia phage JM-2012, complete genome) position: , mismatch: 8, identity: 0.75

ctactgctttaaaaaaagactcatcatcaagt	CRISPR spacer
caagtgctttataaaaacactcatcatacata	Protospacer
* * ******* ***** *********  *

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP018024

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP018025

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection