CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP018218	Lactobacillus delbrueckii subsp. jakobsenii ZN7a-9 = DSM 26046, complete genome	3 crisprs	Cas14u_CAS-V,WYL,cas14j,cas3,DEDDh,cas1,cas2,csn2,DinG,csa3,c2c9_V-U4	0	7	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018218_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018218_1

1132195-1132957

TypeII-A

Consensus_repeat	Method
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	PILER-CR
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CRISPRCasFinder
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CRT

11 spacers

csn2,cas2,cas1

The CRISPR arrays of NZ_CP018218_1

>merge|NZ_CP018218|1|1132195-1132957|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCTACATTGACTAGGTCATCCCACAACTTGGAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCACGCCAATGGCAATCACAATTACCTTCTTGGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCGCCACGCTATCCGCAAGGTTCGGGAATGCAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCGGAATTGCCGTTGCTGTCGACATGGGCAAAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCTCTTACAAAAGCCCGAGGAGCTACCTCAGAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCTCGGCATCCCTGACGCTCAAACCCTTTACCGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCAGATAGCGTTGACCCAGTAATTCCTGCTTTGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCGACCTTCGAAAAGTTGTAGTCACGGTCTTCGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCTTGCTGGGAAAGCCCCTAATGCCTTGATACGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCTCTAGCAAGAGAGAAGTGACAGACAAGCTTGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCAGCTCTATTACTTTTGCTTCCGCTTACATCTTTTTAGAAGGCTGTCTATTCAATAAGGTTTAACCC

>NZ_CP018218|1|1|1132195-1132957|PILER-CR
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TACATTGACTAGGTCATCCCACAACTTGGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACGCCAATGGCAATCACAATTACCTTCTTG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GCCACGCTATCCGCAAGGTTCGGGAATGCA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CGGAATTGCCGTTGCTGTCGACATGGGCAAA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TCTTACAAAAGCCCGAGGAGCTACCTCAGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TCGGCATCCCTGACGCTCAAACCCTTTACC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AGATAGCGTTGACCCAGTAATTCCTGCTTT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GACCTTCGAAAAGTTGTAGTCACGGTCTTC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TTGCTGGGAAAGCCCCTAATGCCTTGATAC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TCTAGCAAGAGAGAAGTGACAGACAAGCTT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AGCTCTATTACTTTTGCTTCCGCTTACATC
TTTTTAGAAGGCTGTCTATTCAATAAGGTTTAACCC

>NZ_CP018218|1|1|1132195-1132957|CRISPRCasFinder
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TACATTGACTAGGTCATCCCACAACTTGGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACGCCAATGGCAATCACAATTACCTTCTTG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GCCACGCTATCCGCAAGGTTCGGGAATGCA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CGGAATTGCCGTTGCTGTCGACATGGGCAAA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TCTTACAAAAGCCCGAGGAGCTACCTCAGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TCGGCATCCCTGACGCTCAAACCCTTTACC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AGATAGCGTTGACCCAGTAATTCCTGCTTT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GACCTTCGAAAAGTTGTAGTCACGGTCTTC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TTGCTGGGAAAGCCCCTAATGCCTTGATAC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TCTAGCAAGAGAGAAGTGACAGACAAGCTT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AGCTCTATTACTTTTGCTTCCGCTTACATC
TTTTTAGAAGGCTGTCTATTCAATAAGGTTTAACCC

>NZ_CP018218|1|1|1132195-1132957|CRT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TACATTGACTAGGTCATCCCACAACTTGGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACGCCAATGGCAATCACAATTACCTTCTTG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GCCACGCTATCCGCAAGGTTCGGGAATGCA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CGGAATTGCCGTTGCTGTCGACATGGGCAAA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TCTTACAAAAGCCCGAGGAGCTACCTCAGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TCGGCATCCCTGACGCTCAAACCCTTTACC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AGATAGCGTTGACCCAGTAATTCCTGCTTT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GACCTTCGAAAAGTTGTAGTCACGGTCTTC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TTGCTGGGAAAGCCCCTAATGCCTTGATAC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TCTAGCAAGAGAGAAGTGACAGACAAGCTT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AGCTCTATTACTTTTGCTTCCGCTTACATC
TTTTTAGAAGGCTGTCTATTCAATAAGGTTTAACCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018218.1\|WP_002877504.1\|1123733_1124402_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP018218.1\|WP_002877521.1\|1120442_1120667_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379188
NZ_CP018218.1\|WP_002877508.1\|1123122_1123731_+\|(p)ppGpp-synthetase	unknown	unknown	gnl\|CDD\|225232
NZ_CP018218.1\|WP_035162685.1\|1131192_1131498_+\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
NZ_CP018218.1\|WP_002877493.1\|1133318_1134419_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_CP018218.1\|WP_002877490.1\|1135650_1136814_+\|hydroxymethylglutaryl-CoA-synthase	unknown	unknown	gnl\|CDD\|213655
NZ_CP018218.1\|WP_002877489.1\|1136978_1138337_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NZ_CP018218.1\|WP_002877527.1\|1119915_1120119_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018218.1\|WP_002877483.1\|1142338_1142776_+\|D-tyrosyl-tRNA(Tyr)-deacylase	unknown	unknown	gnl\|CDD\|235383
NZ_CP018218.1\|WP_035176458.1\|1121333_1121825_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|237224
NZ_CP018218.1\|WP_002877503.1\|1124404_1125664_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP018218.1\|WP_002877481.1\|1143060_1144347_+\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|273080
NZ_CP018218.1\|WP_002877500.1\|1130303_1131215_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NZ_CP018218.1\|WP_002877480.1\|1144362_1146207_+\|aspartate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234775
NZ_CP018218.1\|WP_002877491.1\|1134420_1135647_+\|hydroxymethylglutaryl-CoA-reductase,-degradative	unknown	unknown	gnl\|CDD\|153082
NZ_CP018218.1\|WP_002877496.1\|1131494_1132163_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
NZ_CP018218.1\|WP_002877485.1\|1138963_1139908_+\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|234786
NZ_CP018218.1\|WP_080638354.1\|1121743_1122937_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|236111
NZ_CP018218.1\|WP_002877484.1\|1140048_1142310_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NZ_CP018218.1\|WP_002877487.1\|1138394_1138901_-\|aminoacyl-tRNA-deacylase	unknown	unknown	gnl\|CDD\|237976

Protein	Function_ID	Function_description	E-value
NZ_CP018218.1\|WP_002877504.1\|1123733_1124402_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.19031e-66
NZ_CP018218.1\|WP_002877521.1\|1120442_1120667_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	0.00315006
NZ_CP018218.1\|WP_002877508.1\|1123122_1123731_+\|(p)ppGpp-synthetase	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	1.26467e-64
NZ_CP018218.1\|WP_035162685.1\|1131192_1131498_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	3.0201e-28
NZ_CP018218.1\|WP_002877493.1\|1133318_1134419_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	4.30266e-162
NZ_CP018218.1\|WP_002877490.1\|1135650_1136814_+\|hydroxymethylglutaryl-CoA-synthase	gnl\|CDD\|213655	TIGR01835, 3-hydroxy-3-methylglutaryl_CoA_synthase, 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade. This clade of hydroxymethylglutaryl-CoA (HMG-CoA) synthases is found in a limited spectrum of mostly gram-positive bacteria which make isopentenyl pyrophosphate (IPP) via the mevalonate pathway. This pathway is found primarily in eukaryotes and archaea, but the bacterial homologs are distinct, having aparrently diverged after being laterally transferred from an early eukaryote. HMG-CoA synthase is the first step in the pathway and joins acetyl-CoA with acetoacetyl-CoA with the release of one molecule of CoA. The Borellia sequence may have resulted from a separate lateral transfer event.	7.30295e-131
NZ_CP018218.1\|WP_002877489.1\|1136978_1138337_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	3.86727e-64
NZ_CP018218.1\|WP_002877483.1\|1142338_1142776_+\|D-tyrosyl-tRNA(Tyr)-deacylase	gnl\|CDD\|235383	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional.	2.66737e-86
NZ_CP018218.1\|WP_035176458.1\|1121333_1121825_+\|FAD-binding-protein	gnl\|CDD\|237224	PRK12842, PRK12842, putative succinate dehydrogenase; Reviewed.	1.9373e-07
NZ_CP018218.1\|WP_002877503.1\|1124404_1125664_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.9534e-28
NZ_CP018218.1\|WP_002877481.1\|1143060_1144347_+\|histidine--tRNA-ligase	gnl\|CDD\|273080	TIGR00442, hisS, histidyl-tRNA synthetase. This model finds a histidyl-tRNA synthetase in every completed genome. Apparent second copies from Bacillus subtilis, Synechocystis sp., and Aquifex aeolicus are slightly shorter, more closely related to each other than to other hisS proteins, and actually serve as regulatory subunits for an enzyme of histidine biosynthesis. They were excluded from the seed alignment and score much lower than do single copy histidyl-tRNA synthetases of other genomes not included in the seed alignment. These putative second copies of HisS score below the trusted cutoff. The regulatory protein kinase GCN2 of Saccharomyces cerevisiae (YDR283c), and related proteins from other species designated eIF-2 alpha kinase, have a domain closely related to histidyl-tRNA synthetase that may serve to detect and respond to uncharged tRNA(his), an indicator of amino acid starvation; these regulatory proteins are not orthologous and so score below the noise cutoff. [Protein synthesis, tRNA aminoacylation].	0
NZ_CP018218.1\|WP_002877500.1\|1130303_1131215_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	2.78961e-95
NZ_CP018218.1\|WP_002877480.1\|1144362_1146207_+\|aspartate--tRNA-ligase	gnl\|CDD\|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NZ_CP018218.1\|WP_002877491.1\|1134420_1135647_+\|hydroxymethylglutaryl-CoA-reductase,-degradative	gnl\|CDD\|153082	cd00644, HMG-CoA_reductase_classII, Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR). Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR), class II, prokaryotic enzyme is a homodimer. Class II enzymes are found primarily in prokaryotes and Archaeoglobus fulgidus and are soluble as they lack the membrane region. Enzymes catalyze the synthesis of coenzyme A and mevalonate in isoprenoid synthesis. Bacteria, such as Pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3-hydroxy-3-methylglutaryl-CoA. Human and bacterial HMGR differ in their active site architecture.	0
NZ_CP018218.1\|WP_002877496.1\|1131494_1132163_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	1.13508e-68
NZ_CP018218.1\|WP_002877485.1\|1138963_1139908_+\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|234786	PRK00517, prmA, 50S ribosomal protein L11 methyltransferase.	4.26568e-93
NZ_CP018218.1\|WP_080638354.1\|1121743_1122937_+\|FAD-binding-protein	gnl\|CDD\|236111	PRK07843, PRK07843, 3-oxosteroid 1-dehydrogenase.	1.28521e-32
NZ_CP018218.1\|WP_002877484.1\|1140048_1142310_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NZ_CP018218.1\|WP_002877487.1\|1138394_1138901_-\|aminoacyl-tRNA-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	1.17301e-65

>NZ_CP018218.1|WP_002877496.1|1131494_1132163_+|type-II-A-CRISPR-associated-protein-Csn2
MIITYKAHKSFEIENGKVNVIATSSPIAYCNLIEGIQEKNELLCAVSEDYDAIPLSKAVDWLGDPLISESLLQKYMTKLASYVVDELSADGRNRIITCYRDLLNAVQDELLMEDLPLEISFDTDLKKLFKFGGLHFNKTLTRDPYGIIETVLRIHDRLDLKSTVVFSNVAHYLDAEQFNEISKLCLELKKSIIFIEFCSHKDQVVYGDAKFSYIDEDLVDWY
>NZ_CP018218.1|WP_035162685.1|1131192_1131498_+|CRISPR-associated-endonuclease-Cas2
MRLMIMFDLPVDTAVDRKQYRQFRKNLINEGFVMIQYSVYVRVCASKKAAELLEKRIRGYVPEYGVIQSLMLTEKQYNDMHFLLGEPVKDIRNTSDRTVIL
>NZ_CP018218.1|WP_002877500.1|1130303_1131215_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRNVIITQHSKLSYSSNMMVVHTKDGVSQIPVSDINMLVVLTTQAVITSALIAELAKKQTKVIFVDEKQEPICETENYYSTNCHPEKLIKQFNWDEDRKQILWTKIVAAKIQNQMNVLRIYGLPTDEIEKDFLELELNDASNREATTARKYFTELFGKDFKRREGSNALNAALNYGYSILLSAVNRKITMDGNRTYMGVHHSSEHNPFNLGSDLMEPFRPFVDYWLYDHKNIKEFTPDIKYGLVELLSLRIIYNGDRMILGNAINQYVHDCLRYLDGNLFEMDIELGVDYEVPNDAIDDNV
>NZ_CP018218.1|WP_002877503.1|1124404_1125664_+|HAMP-domain-containing-histidine-kinase
MIKKIRRRFIWLATLSLFLVMFFSFSSLIGISLFESSHEADQVLSIIVKNNGRLDEAQAKKRLGDQYNKEGIFKYRYFTANINTKKQTLTVIDADHIIGYSINSVSSRKKQISMRLSAGQLKGTIQSNGVRFRYLAKKISANKYYICFIDLSPLMQSALLLVRYALIFTFSGILFFVIIMALLADKAIQPIKDAYDKQRRFITNAGHELKTPLAVISANAEMEELLGNDDEWNESTKEQVVRMTGLINQLITLTRMSEPEELVLSKVNFSEITKESADSFKSVLAKDNKKYVVSIDPDLYINAEQHSLLELVNILIDNAQKYCDPEGEVMVVLAKSRLNQNAVLTVTNSYKNGAGIDTNRFFERFYREDESHHYDQKQKNGFGIGLSMAQDLVAAFGGKINASWSDGVMNVTVTFKRVH
>NZ_CP018218.1|WP_002877504.1|1123733_1124402_+|response-regulator-transcription-factor
MKILLAEDEAQLNRVLTVAMQKSGYDVDSVFNGQEAVDAVKKHPYDVIIMDIMMPVKNGLDAVKEIRATGDKTYIMMLTAKSEIDDKVTGLDGGADDYLTKPFSLKELLARLRSKERRSEDYNSTQELNYDNLKLDLNSQELSSNNSIRLSKQETSLMRYFLLNPGKAISTEELFNHVWKNEDESEDVVWVYVSFLRSKLASIGANVQISGEKGGEFCLERA
>NZ_CP018218.1|WP_002877508.1|1123122_1123731_+|(p)ppGpp-synthetase
MSIYGKYADYLPQILDSVLQQIQGIGQEYSAKHGQKLYEHLESRVKGEESMTQKCERKGLPLTPESALIENRDAIGLRIVCNFIDDIYTCIDLLKKQDNFKIINEKDYITDAKPNGYRSYHLIMEVVTPFEDVHGNKPGTYYVEIQLRTIAMDTWASLEHEMKYKHDIKNPERISKELKRVADELASCDVSMQTIRQLIKEG
>NZ_CP018218.1|WP_080638354.1|1121743_1122937_+|FAD-binding-protein
MEIGYQFKEANFRFKTPFVDEKGGFHLILTDVDKRVRLWTEAYEKYGVDAFFNTAAKEVLKENGKIAGVAGQRKDGSKVTVHAKSVIIASGGYLGNKELLLKYLGTTHVNVAARGKSLCTGDGLAIAQKAGTILDKTFGYCGCEYGGTNPKASRPATQDKYDQNLAFKFGIYGNLLVDNQGKRFMNEGLLCDYPMSYGEEPTLRHSPYYAIVDQEYVDKMRDEGLYEYLTKRGANHDNWFIGSYYKQRGGLRSLDSDLEEGIHEGWIVKADTLEELAKKTGFDHLTGTVASYNSYCEKGEDEQFGANPWYLSSVKQGPFYAIECEVSAWSTFGGVKTDDECRALAEDDQVIPGMYVVGTDNGSMMYSPYYDIPGFCYGSCIGSGVIAGHGASAYAKA
>NZ_CP018218.1|WP_035176458.1|1121333_1121825_+|FAD-binding-protein
MTKAVTSSVEEAITEAGGDPKTFTEAAHVTETKLPDADVTADVVVIGSGASSFMSAITAAKAGSKVVVLEKAGNLAAVNGVKVSGPFAVNTPVLRERGTTLTVNEVFQHVMNYTHWEPKSALIRNYLEHRVKRLKTYWRSVTNLRKQTSVLKLLSSMKRAASI
>NZ_CP018218.1|WP_002877521.1|1120442_1120667_-|helix-turn-helix-transcriptional-regulator
MNALQEYLNQNGVTRYQVAKQTGIANTTLANAVKETKPLSGQTVKVITAVAQALSKTPGQVLDDLIELDEDNSK
>NZ_CP018218.1|WP_002877527.1|1119915_1120119_+|hypothetical-protein
MSESKEDKRMRAKWESLSGAEKSEFKKNYAMRRGITIDFIRRWAWNEGDLDNLEYRIAERRKKFREF
>NZ_CP018218.1|WP_002877493.1|1133318_1134419_+|thiolase-family-protein
MQDIYIVAAKRTPFGRYHKQLADFSAIDLGQIALRGALKEAGLDAKALDALFMGNVLSAGLGQNIARQIALNAGMRQDSVAVSINEVCGSSLKAARLAEAQMLIGDLGLVAVGGSESMTNAPKEIMFSDGLVDSFSGKSMGITAENVAKRNHISRQDADAFSLSSHQKAVKAQAEGLFADEIIQIEDLKQDENVRPDTSLEALAGLKTSFLEDGTVTAGNASPISDGASMIILATAEKVAEYQLTPLAKLGAYAEVGYDPEFMGYGPYYAIRKLLDETGRQVADYDFFEINEAFAATTLAVARDLEIPLAKVNKQGGAIALGHPLGASGTRLLATAARQLQRGGQRAIASLCIGGGLAIAFEIEKA
>NZ_CP018218.1|WP_002877491.1|1134420_1135647_+|hydroxymethylglutaryl-CoA-reductase,-degradative
MKFYQLPPEERRQFLQEDGVALEDIPAADLARLDEMSENVVSEVKFPLSCLTSALVNGKNWRIPMTTEEASVVAAANHGMSVFAKAGGVKATSQRDGIYGQIVLEVTEAFSLADFKNKFPTYIKEANKEFASLIRHGGGLKDLTARQEADLVYLLALVDPAEAMGANKTNAIMEFLAQKMLAFPGVEAKLFAILSNYPSQLTTAKVTIPVSLLSKKGDLAEGREVAKKMALLAKIGSRDPYRAVTNNKGIMNGVDAVMLATGNDYRAVEASCHAYAAKSGQYRSLSSWKLEGENLLGQVTLPLALGVVGGSISSRPDIRQSYAILGKIKAAELAELTASVALANNFAALNAISTKGIQAGHMRLQSRNVVQTLPAAAEEKEAVYQMMISQGKYGETAAKNFLKELRGQ
>NZ_CP018218.1|WP_002877490.1|1135650_1136814_+|hydroxymethylglutaryl-CoA-synthase
MDIGIDQIGFYTPNKFVDMVDLANARNQDPNKFLIGIGQDRMAVADKTQDAVSMGINATAEYLDQVDLEQLGLLIFATESGIDQSKSASLFVKEALNLPARIRTFEIKEACFALTASLQVARDYVRAHPHHSAMIIGSDIARYGLATAGEVTQGAGAISMLIKENPAIIALEDGHTSHSENINDFWRPNNLATAVVDGHYSRDVYLDFFKSTFKPFLAEKQLQVSDFAGICYHLPYTKMGYKAHKIAIEGQDDETVKRLSDNFQLSAKYSRQVGNIYTASLYMSVLSLLENGNLEAGDRIGFFSYGSGAMAEFFSGKVVAGYQKRLRPALHARMLKERIRLGVGQYEDIFTEGLEALPENVEFTSDANHGTWYLAGQEGYVRQYKQK
>NZ_CP018218.1|WP_002877489.1|1136978_1138337_+|threonine/serine-exporter-family-protein
MKTESTEQEYHHHLSHHHHMRVQWEEFFQSDDETKIKEATLIEKGSIISRVGMMMLSCGTGAWRVRDAMDTLARTLDLTCSTDIGLISIVCTYFDVDNQSYSQSLALPTTGVNMAKLNELEKFVRQFEAAGGDFEIKTIRRRLGEIEHMKGRYPLWGSSLAAALACGGFIFLLGGGIPEIICSFIGAGLGQFARGSLAKRRITIAATTAVGVAAACLSYYLAFMLGHLLFNVDMIHMRGYIGAMLFVIPGFPFITSGLDISKLDMRSGLERMAYAIFIILIATGTGWVMATALQIKPGDLPALHLSKAILTACRLVASFCGVFGFSLMFNSHRRMAAAAGLVGAIANTMRLSLVDFAHFPAPLAAFLAALLAGLLAGYVREKVGYPRIALTVPSIVIMVPGLYMYRGIFLLVLTNVGAGATWMTEALMLVMSLPAGLLTARILTDKKWRRVD
>NZ_CP018218.1|WP_002877487.1|1138394_1138901_-|aminoacyl-tRNA-deacylase
MSKKKKNKDKLDKTLVEKILDQHKIAYEQHISEISEDHGVAQVGTGKPVLDGHPVYKTLAVNGNKTGPIVGVVPLSGHLDLKKIAKASGNKKCEMIPLKQLEKTTGYVHGANTPIGIYHSKKFPIFLDKSVLNEDGIWVSSGEVGRSVMVNPLDLQKLVKATVADLQE
>NZ_CP018218.1|WP_002877485.1|1138963_1139908_+|50S-ribosomal-protein-L11-methyltransferase
MKLLEIKIESSYDVEDALAYFATEDLKALGTEARRRSDFEQAGWLHDSTVVDMDDIPNLPDELEFIAYFDEETDPEETVKCFKDKLAELAGYGLKTAPGKISVDYVADQDWNTVWQKYYHVINLSRHLAIVPEWEDYQPVFKDQEIIRLDPGLAFGTGNHQTTQLAMLGIERAMVKPLTVADVGTGSGILAIAAHKLGAKSVLATDISDESMTAAKENAALNGIHDIALQKTSLLAGVDGKFDLIVANILAEILLDLIPQLDSHLNEDGQVIFSGIDYLQLPKIEQALAENGFQIDLKMRAGRWIGLAISRKHD
>NZ_CP018218.1|WP_002877484.1|1140048_1142310_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MSKYIEMTHEQVMAACKKYMTADQLAFVESAYQFAARAHEGQTRASGQPYIVHPTQVAGTLANLGLDPDTVAAGFLHDTVEDTSVTNDDIKEKFGADVAFIVDGVTKLNKYEYKSHKEFLAENHRKMLIAMAKDLRVILVKLADRLHNMHTLEHLRPDKQRRIAAETLDIYAPLADRLGIGTIKWELEDMSFHYMNPEEYYKIVSMMNAKRSEREDYIKDAIDYLRGTLDSLGIKYDISGRPKHIYSIYKKMVNKHKDFNEIYDLLAVRVIVPTVKDCYAVLGAVHTKWKPMPGRFKDYIAMPKANGYQSLHTTIIGPGGKPLEIQIRTEEMHKVAEYGVAAHWAYKRGNFQGVDEKDGGALDIGREILELQKDSKNADEFMEAVHSDIFADKVYVFTPKGEVYELPKGSVTLDFAYAIHTQVGDHGIGAKVNDKLVPLDYKLKNGDVVDILTQSNARPSRDWAEMVKTSRAKNKIRRYFRDVDREESLARGKSELVDLLKENGLSAKDFLDKSHIDEVLDHFSFKTDEDMYAAIGFGNMSAVCIYNRLTADLRRQQEEEKQKQFEAQIMSAGQQAAASSVVKKPASQKDDAKSKTKGKKRDSLVRVQGLEDLDMHFAKCCNPVPGDPIVGYVTKGRGVTVHRADCRNVVSADPAAQGRMIDVEWNNIDEGKQASFNANFELFGYNRQKLLGDVINRLNALTKNITNVSASVNEENIAHFYITVEVRNAAQLNDIMAKLRDIPDVYDTKRTDN
>NZ_CP018218.1|WP_002877483.1|1142338_1142776_+|D-tyrosyl-tRNA(Tyr)-deacylase
MRVVIQRVNHAAVRIDGETVGQIQKGLLLLVGLAEGDGEEQVVKAADKIAKMRIFEDEAGKTNLGIKDVGGQILSVSQFTLLADTKKGNRPSFVHAMRPPKSSQLWEEFNQGLVKRGLTVETGEFGADMKVELENDGPFTIVLDL
>NZ_CP018218.1|WP_002877481.1|1143060_1144347_+|histidine--tRNA-ligase
MRVQRPKGTVDILPETSGQWEKVEQTARDLFKRANYHEIRTPSFENYELFSRSSGETSDVVEKEMYDFEDKGGRHIALRPEGTAGVVRAYVENKIYGPDYVKPFNVYYIAAMYRYERPQAGRQREFHQIGVESFGSNGYLADVETILLGHDLLAELGVKNYELHINTLGDSEVRQAYHDALVDYFTPVKDQLSEDSQRRLGKNPLRILDSKAEEDQQFLPEAPKIRDYLDEESKENFNKILASLDKLGVKYVIDDDLVRGLDYYTGVIFEFMVDDPTLWASPSTVLGGGRYNHLVEEFSGPETPAVGFGIGEERLMLVLSKQNPEMFEDQGIDFFITNIGEGTDIKAVEVARQLRSLGFSAQYDVDQKKLKAQFRKADRVGARYVVTLGAKELAEGKLTVKRLSDGQQFSLEFTDLEDKADLLSKIEK
>NZ_CP018218.1|WP_002877480.1|1144362_1146207_+|aspartate--tRNA-ligase
MMQMEKRTDYCGNITSQYLDQDVLLYGWVQRVRNLGQLIFIDLRDREGIVQVVVNHDSGQELMDVASSLGQEYVVEVKGHVNERSSKNPDMKTGDVEVIASEITVLNKAKTPPFEIKDDLVASEQTRLKYRYLDLRRPTLQNALIMRAQIMTATNAYLSGEGFINIETPDLGKSTPEGARDYLVPSRVYPGSFYALPQSPQIFKQLLMGAGFDKYYQIARCFRDEDLRGDRQPEFTQIDLETSFMDEEGVQEVTEGLLAKVMKDVKGIDLQLPLPRITWQESMDKYGCDKPDTRYEMLIHDLGNVFAKSGFKVFASALENGGFVRGIAVKGGAKFYSRKKIEAMQDYIKRYHAKGLAWVKYEDGDFSGPVSRFLSEDEKAGLVQEFSLEGGELLLFIADQWKVCCDSLDYLRRQTAKETGIIPKDTYKYLWVVDWPLFEYDEGDERWIAAHHPFTMPDDKGIELLETDPHKAHARSYDIVLNGYELGGGSIRIHKRDIQEKMFKALGFTKERAYEQFGFLMDALDMGFPPHAGLAIGLDRFAMLLAGKDNIRDVIAFPKNASASEPMMHAPAPVADQQLTDLGIEVAEAAKEGVEKYEASLEAEAAEDVKSHEE

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Crispr_ID: NZ_CP018218_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018218_2

1301630-1302111

Orphan

Consensus_repeat	Method
TCTCCGCTAAAAGGAGACGAGAAC	CRT
GCTAAAAACTTATCTCCGCTAAAAGGAGACGAGAACT	PILER-CR

6 spacers

The CRISPR arrays of NZ_CP018218_2

>merge|NZ_CP018218|2|1301630-1302111|CRT,PILER-CR
TCTCCGCTAAAAGGAGACGAGAACTCAACGTTAAAGTTGATAATCATTCTATAACTATTATCCTTGCTAAAAACTTGTCTCCGCTAAAAGGAGACGAGAACTCAACGTTAAAGTTGATAATCATTCTATAACTATTATCCTTGCTAAAAACTTGTCTCCGCTAAAAGGAGACGAGAACTTTAAAATGGCAAATCAGTAAATTCAATTCCACGAGTTAGCTAAAAACTTATCTCCGCTAAAAGGAGACGAGAACTTATCTTCAGCAAGAGTTACTTCGCCGTACAGGACTTCATCTGCTAAAAACTTATCTCCGCTAAAAGGAGACGAGAACTAAATTGCTCTGCCCACTCATCGAGGTCACTTCGCTTATAGCGGGCTAAAAACTTATCTCCGCTAAAAGGAGACGAGAACATAATGAAAGCTTGACCATCAATTACAACGCTTACGCTAACAACTTATCTCCGCTAGAAGGAGACTTGAAC

>NZ_CP018218|2|2|1301630-1302111|CRT
TCTCCGCTAAAAGGAGACGAGAAC	TCAACGTTAAAGTTGATAATCATTCTATAACTATTATCCTTGCTAAAAACTTG
TCTCCGCTAAAAGGAGACGAGAAC	TCAACGTTAAAGTTGATAATCATTCTATAACTATTATCCTTGCTAAAAACTTG
TCTCCGCTAAAAGGAGACGAGAAC	TTTAAAATGGCAAATCAGTAAATTCAATTCCACGAGTTAGCTAAAAACTTA
TCTCCGCTAAAAGGAGACGAGAAC	TTATCTTCAGCAAGAGTTACTTCGCCGTACAGGACTTCATCTGCTAAAAACTTA
TCTCCGCTAAAAGGAGACGAGAAC	TAAATTGCTCTGCCCACTCATCGAGGTCACTTCGCTTATAGCGGGCTAAAAACTTA
TCTCCGCTAAAAGGAGACGAGAAC	ATAATGAAAGCTTGACCATCAATTACAACGCTTACGCTAACAACTTA
TCTCCGCTAGAAGGAGACTTGAAC

>NZ_CP018218|2|2|1301847-1302041|PILER-CR
GCTAAAAACTTATCTCCGCTAAAAGGAGACGAGAACT	TATCTTCAGCAAGAGTTACTTCGCCGTACAGGACTTCATCT
GCTAAAAACTTATCTCCGCTAAAAGGAGACGAGAACT	AAATTGCTCTGCCCACTCATCGAGGTCACTTCGCTTATAGCGG
GCTAAAAACTTATCTCCGCTAAAAGGAGACGAGAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018218.1\|WP_002876950.1\|1295737_1297732_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|274475
NZ_CP018218.1\|WP_002876961.1\|1291432_1291630_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018218.1\|WP_035176908.1\|1315903_1316764_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|378925
NZ_CP018218.1\|WP_002876949.1\|1297742_1298120_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018218.1\|WP_002876960.1\|1291641_1292880_+\|site-specific-DNA-methyltransferase	unknown	unknown	gnl\|CDD\|334588
NZ_CP018218.1\|WP_002876947.1\|1298132_1299818_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274108
NZ_CP018218.1\|WP_002880287.1\|1313384_1314026_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271192
NZ_CP018218.1\|WP_002880289.1\|1314217_1314688_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP018218.1\|WP_002880280.1\|1308010_1311211_-\|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|235393
NZ_CP018218.1\|WP_072557724.1\|1307575_1307908_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213218
NZ_CP018218.1\|WP_002876951.1\|1295532_1295736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018218.1\|WP_002876957.1\|1292881_1293430_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018218.1\|WP_080638351.1\|1290867_1291284_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376574
NZ_CP018218.1\|WP_002880291.1\|1314992_1315907_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP018218.1\|WP_002876952.1\|1293416_1295555_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|274978
NZ_CP018218.1\|WP_002880268.1\|1302681_1303341_+\|DUF3232-domain-containing-protein	unknown	unknown	unknown
NZ_CP018218.1\|WP_002880277.1\|1306764_1307514_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_CP018218.1\|WP_133281428.1\|1304248_1304887_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|376885
NZ_CP018218.1\|WP_080638352.1\|1290396_1290867_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376574
NZ_CP018218.1\|WP_002880274.1\|1305484_1306186_+\|TIGR00266-family-protein	unknown	unknown	gnl\|CDD\|224924

Protein	Function_ID	Function_description	E-value
NZ_CP018218.1\|WP_002876950.1\|1295737_1297732_+\|AAA-family-ATPase	gnl\|CDD\|274475	TIGR03185, DNA_S_dndD, DNA sulfur modification protein DndD. This model describes the DndB protein encoded by an operon associated with a sulfur-containing modification to DNA. The operon is sporadically distributed in bacteria, much like some restriction enzyme operons. DndD is described as a putative ATPase. The small number of examples known so far include species from among the Firmicutes, Actinomycetes, Proteobacteria, and Cyanobacteria. [DNA metabolism, Restriction/modification].	1.63392e-31
NZ_CP018218.1\|WP_035176908.1\|1315903_1316764_+\|ABC-transporter-permease-subunit	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	3.48017e-07
NZ_CP018218.1\|WP_002876952.1\|1293416_1295555_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|274978	TIGR04095, type_III_restriction_protein_res_subunit, DNA phosphorothioation system restriction enzyme. The DNA phosphorothioate modification system dnd (DNA instability during electrophoresis) recently has been shown to provide a modification essential to a restriction system. This protein family was detected by Partial Phylogenetic Profiling as linked to dnd, and its members usually are clustered with the dndABCDE genes.	4.80065e-104
NZ_CP018218.1\|WP_002876947.1\|1298132_1299818_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274108	TIGR02393, RNA_polymerase_sigma_factor_RpoD, RNA polymerase sigma factor RpoD, C-terminal domain. This model represents the well-conserved C-terminal region of the major, essential sigma factor of most bacteria. Members of this clade show considerable variability in domain architecture and molecular weight, as well as in nomenclature: RpoD in E. coli and other Proteobacteria, SigA in Bacillus subtilis and many other Gram-positive bacteria, HrdB in Streptomyces, MysA in Mycobacterium smegmatis, etc. [Transcription, Transcription factors].	9.92524e-36
NZ_CP018218.1\|WP_002880287.1\|1313384_1314026_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271192	cd01192, INT_C_like_3, Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain. Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	5.85195e-43
NZ_CP018218.1\|WP_002880289.1\|1314217_1314688_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.01852e-16
NZ_CP018218.1\|WP_072557724.1\|1307575_1307908_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213218	cd03251, ABCC_MsbA, ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C. MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	8.97726e-26
NZ_CP018218.1\|WP_080638352.1\|1290396_1290867_-\|hypothetical-protein	gnl\|CDD\|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	2.77092e-15
NZ_CP018218.1\|WP_002880291.1\|1314992_1315907_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.94288e-97
NZ_CP018218.1\|WP_002876960.1\|1291641_1292880_+\|site-specific-DNA-methyltransferase	gnl\|CDD\|334588	pfam01555, N6_N4_Mtase, DNA methylase. Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	3.19645e-42
NZ_CP018218.1\|WP_080638351.1\|1290867_1291284_-\|hypothetical-protein	gnl\|CDD\|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	1.88419e-20
NZ_CP018218.1\|WP_002880277.1\|1306764_1307514_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	2.31952e-20
NZ_CP018218.1\|WP_133281428.1\|1304248_1304887_+\|Fic-family-protein	gnl\|CDD\|376885	pfam02661, Fic, Fic/DOC family. This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.	2.86319e-19
NZ_CP018218.1\|WP_002880280.1\|1308010_1311211_-\|carbamoyl-phosphate-synthase-large-subunit	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
NZ_CP018218.1\|WP_002880274.1\|1305484_1306186_+\|TIGR00266-family-protein	gnl\|CDD\|224924	COG2013, COG2013, Uncharacterized conserved protein [Function unknown].	5.10961e-64

>NZ_CP018218.1|WP_002876947.1|1298132_1299818_+|sigma-70-family-RNA-polymerase-sigma-factor
MAYVEYAFRDDPYTIALLEDAGRKIKDCCQIMTFGRHLVKPEIMGQYLFFFPYAIWNGHGKYHGDANKLMMLMEDHDINPEYNYVAVIESQVEFQVRSDALKNISQYYAPAWNMRSYLNYFSDIPSGVIFFLRVFRIDTAADLSLMEKGSKGSVQVFRLYDRYENETSAEISGMTPVISDNRFQYLKDEIISDLKVDGVFIAEYSNTDKGKSDLQERLDAAKALYGEFHWGGSVKVQALKEIGYKLGVDEDFDMAQLDYDAIFDEAEAVCPAMKGMLKDIRNIQAARLGEYDYNLEMVHKRGPDAQDASLRIFDMVLRSCVKVALYAYKDNGMEFEDAFQEACIGAWTAIWKHSDSVEGLFPSYASMWMSQVMHRDLPYLHQTCYVSVHTVEQINQYLNQIEKIVGPTDFNNLSERELHDLLKKYTDWPEERITQVLYILLTPESIETLQEETDGNAFVSDENVEDDVISRVQSEQLTELALRGLSDRERSVIEKRYGLADGNEHTLEEIGQEMSVTRERVRQIESKAKKKIAAKFYANHVISHARFISVVPEGNLGRKKK
>NZ_CP018218.1|WP_002876949.1|1297742_1298120_+|hypothetical-protein
MVEDITNLRLSRLATHVATEMKESGLFEDALTAAKFGMAYAVKYNLDDVNSDDKIAQLDAVYDATGNNYNVGSVDPDHYIADFIGALYPGCTTPYRYARVLMCYGLNKLGDFLDEGKLFPINQYM
>NZ_CP018218.1|WP_002876950.1|1295737_1297732_+|AAA-family-ATPase
MLHFTRMTLTNFGPYKGEQTIDFTDKSGVIIFWGNNGRGKTTLLNAFRFALFGKIQRRNGVLKHLKEMENTEAADAGQHGFKVVLEMTNDGDIYALTRQYMPRQGVTDPAGDEDYEKVTFLRKNGAILSPEDRDHELKVIMPEQVSRFFLFDAELLQEYEELVSSDDYSGEQIKNSIEKILGLPVLQNGCVDIEECLSKYETQKTRAAKTDDRTARYGIELDSINANIKEHVNAIQEKKSQLSDLLGQKTVVEEQMKATNQLREWIIERNNAEKNLKSTEGKLVSVQQKLSALMKNAWKGMLLTTIRDMREKLETEEKVLTSKKQKRTVAESFIKEMKRAVADRTCPVCEQDIDSTIIAELQRKIKESSSEYSGLTEVERGRLYDIHSSLDTLRKLGVDVQDVRQNVKLLEDQKDQLSIECTEYKQQIAEMKDHISRYGMNADENDVLSITTRYSEIDQSIHDIRNGIDAENKKLNELKQQKDKITEAIDRSAGSTDYREASRRYELCDHIFKIFDESKAKYRDQLKANVQSDATELFLNLTEDPDYVRLQINDNYGLEIVHKSGRIVPGRSSGYEHVVALSLIGALHKNAPLQGPIIMDSPFGRLDPTHKANIIRTLPKMAEQSMLLAYTGEIDDQVARQELGASLLHEFKLERVTSMHTEIE
>NZ_CP018218.1|WP_002876951.1|1295532_1295736_+|hypothetical-protein
MTERKNLDELLSVLEKVRSEKYSDVPEELIRQIAYAQYDNQDDRQQARSKTMSLIAEYMNRLNNREG
>NZ_CP018218.1|WP_002876952.1|1293416_1295555_+|DEAD/DEAH-box-helicase
MGLRDYNFKPDYNKTNDDIAEDFYLPAMRNSVRYDRISGYFGSTIYIIAWTALQEFVEHGGKIRIICSPVISDTDKTAMAEGYSAKNDAIIQRNMAEELNNMFLSPELEKPTRVLACLIAENILDIKIAVPETGMEPDLKRLFHDKVGIFTDSNGDSVGFRGSMNETYQGLSEDGNLESIDVFPSWDDRRDSFRVDSAKDYFERLWNEKQPNALVYKFPDALKQKLIDKSNGYDWKALLSEIATGISLAKKWCSDKKSKKKSPRDHQVKALENWVDHDRRGILEHATGSGKTYTAICAIRDALDRGQTVLVLVPSKELLRQWKKEILENISDIQLSILLSGDGNTSWRDGDTLSLWTRKSSGQNKITIAIMDTACNDLFVKNVSDGKHLLLVADEVHRIGSPERRNILNIDAGERLGLSATPIRYGDPEGTAAVFDYFGGIVPPVFSLQDAIRSGVLTKYYYHPLPVLLSEEEQEEWDELTKKINKMIVIGKSKGSSFSSMMQGNTRLQMQLIARARILKQAKAKVPLALDTIKKYYERGQRWIVYCDNQGQLSEVLDLLLRNGYDAYEYHSDMIGSREETLKYFSYNGGILVSIKCLDEGVDIPETTHALILASSKNPREFIQRRGRILRRSKGKYFAQLYDAIVMPQESYQENDKSNSIIEAELSRAIQFGEWAENPSCTADLKIIARKFGIDYQKVKDGGYEDDREEES
>NZ_CP018218.1|WP_002876957.1|1292881_1293430_+|hypothetical-protein
MATRRLKQSELHSLFLTDVGDIAENVESINRKPLRAHLKYPFNRDIKAYVFNCTGPPGGRTVDEWKVQLIIDNQKRGQRGRFDDSDGTTVLIIGYAQILNDTEDGVWVLFELDKHREFAYSANIQIYLRQIMKALETGVYVHKKHNNEIVVIAKRECLVEGLKKRFDIDLQIMLRNAGHGVT
>NZ_CP018218.1|WP_002876960.1|1291641_1292880_+|site-specific-DNA-methyltransferase
MGEFINGECLEEMKKLPDNSIDFIFTSPPYADQIKDYGVTGKSVKIKPSKFNDWFLPRAKEMYRILKPTGSFVLNINDKLDGKYQSLFVFKLVVLLSEKVGFHLVRDYIWYNPATPPNVFSRGTMGRTKKSHEYCFWFSKSDEWTFHMDPIRKPYGDRMEELFKASAKGDRDANTRPSRHSFDLSHPWKNNGGADPGSVLTISNTSSNDTFHRLCKQFGVSHPARFPMKLVEFFVKAGTNKGDVVLDPFGGSGTTAIVAEQLGRDFKYIEINPDYCEMAKKWHQVEFHCEEVWNNNLVRFIDEMLPRCKWQLLPFAYVYDLFESWFPTVGLYEKPRNKTLFYDHLKGILKDNDEWKITDGYVEVNDDNMPLPEPLIKEYNLKNWMNKDCDPDDETSLCSPALNSKYMGIRKV
>NZ_CP018218.1|WP_002876961.1|1291432_1291630_+|hypothetical-protein
MEENNFAVSVNNQSVQAPEDTRATSLVSMTKKDKEYLSAVAKAHGLSLSAFFRLAAEEYIKNHEW
>NZ_CP018218.1|WP_080638351.1|1290867_1291284_-|hypothetical-protein
MIITLYSFPSTTSFDPSDPLPEYLAFDEFRGVGMRLRFICLDSDKYTVVTILPNRYKRSIIRYFEKYSAQDRERVKTASMDLNCYYDVLARRLFPSAEIIIDRFHLIQMVTRSFNSYRVLVMKQADKNRTDPEKGLKH
>NZ_CP018218.1|WP_080638352.1|1290396_1290867_-|hypothetical-protein
MYKGCWKLFLKKYTELEGQKQFFDWRLKCSYTPVQIVDKGLEYDDVLRSSYDFMQDFMIALQDINSTKIAELLDSDINQYCDQLKTTIRTFRKNRKAVINAAKFSYSNGCLEGFNRKIKQIQRTTFGYRNLTTMLKRIRLEQKNVPIQKASSKRFA
>NZ_CP018218.1|WP_002880268.1|1302681_1303341_+|DUF3232-domain-containing-protein
MPYKLTEIQKLDLYIHLNKLNSKIKILSTDEEWANNRKQIGEVLYQLNLVEDPTDMNEVEKANLDYIRKRTKSIIQNSGRKPMAAYFINQKALDELGNLVDEEDENFYSDFHDMLVNDMIKYATIVRDFDLKLAKAKEANDANYYREEYARLDSARRRQHDAVIANLAVANRTNESEGLEPVLDVGDGRSVHDVHRTDIGNAVISWLAETNHQDAQVQN
>NZ_CP018218.1|WP_133281428.1|1304248_1304887_+|Fic-family-protein
MDTLDLSEAYDYMMYLASQAQNLTQLDIRNLNRLAMAKSRPEDAGVYRSVPVRLAGAEVNPYADPWDIAVKMAELVDWANDAQDKFHPVDYAAQLHWRSVIIHPFIDGNGRMARLLMNLALTEHGYPVVNIQPNKESRLNYMEVMEECDRAGSADKLIDLIADYAEEALRKKLKILELSAKNHTDSGYIISERELEEWRKKRKQQLQTKKHA
>NZ_CP018218.1|WP_002880274.1|1305484_1306186_+|TIGR00266-family-protein
MKYELSGGNTCPLATVTLDKGESIKVENGAMVYMKDVTIAGKMNSSKKGLGGLLGAIGRSLTSGESMFITQATGDADGGQIGVAPAIPGKILKLSVGKQQYCLNTGAFLASDDSVSYKMKSQSFSKAAFGGTGGFYVMKTEGEGDMLINALGDLVELTVTSDKPISIDNEHVIAWDANLDYDIKVASGMFGFTSGEGLVNHFTGDGKVIIQTRNLRSLAEALQPFIVEKNSNS
>NZ_CP018218.1|WP_002880277.1|1306764_1307514_+|class-I-SAM-dependent-methyltransferase
MNYQDINAETIDRWVKEGWEWGKAIDHDTFQAAKEGKWEIKLTPVKYVPHSWFGDLQGKKILGLASGGGQQMPILTALGAECTVLDYSDQQLESERLVAEREGYDIDIVKADMTQPLPFADESFDMIIQPVANCYVEKVKPIWKECYRVLKKGGVLLVGLDNGINYLFDSDEEKYVVNSLPFNPLKNPDQMLQLEKDDSGVQFSHTLDEQIGGQLEAGFTLTNLYEDTNGEGRLHELNIPTFIATRSVK
>NZ_CP018218.1|WP_072557724.1|1307575_1307908_-|ATP-binding-cassette-domain-containing-protein
MVGPTGTGKTTLVKLLIRFYELNSGKMTIGGQDTSKMKWSDLRSMFGMDRLMQGRTAFVIAHRLSTIRDADSIIVLKDGDIVEVGNHDSLMAKKGFYADLYQSQFEHSEE
>NZ_CP018218.1|WP_002880280.1|1308010_1311211_-|carbamoyl-phosphate-synthase-large-subunit
MPKRDDIKKVLVIGSGPIIIGQAAEFDYAGTQACRALREEGIEVVLINSNPATIMTDGDMADHVYIEPLTVPVVKQLIEKEKPDALLPTMGGQNALNIAMALADEGFLEKHHVKTIGTDTDTIKMAEDRLEFKNLMERIGEPVAKSVVVNYVEDAIAFAKEIGYPVVVRPAYTLGGTGGGIAYNEQELREICSNGLRLSRVTECLIEQSIAGWKEVEYEVMRDGAGNCITVCNMENMDPVGVHTGDSIVVAPSQTLSDKDYQMLRSSALNIITALNIKGGCNVQFALNPDSFEYCVIEVNPRVSRSSALASKATGYPIAKLATKIALGYNLDEIVNAVTGKTYASYEPTLDYIVCKIPKWPFDKFYDASRKLGTQMKATGEVMAICNNFEGAFMKALRSLEQDSYYLYNEEIAQLSADDLRKDLRKIDDKRAFRIAEALRKGVSIREIHAITKIDVWFIDKIKHLVEIEDRLKSEELTPDLLKLAKHCEFPDRVIASLTGKTADEVYYLRKGLKITAAFKTVDTCAAEFDAETPYFYSVYGGEHEIQPDRSKKKVIVFGSGPIRIGQGIEFDYCCVHSVWALKEAGYETIIVNNNPETVSTDFDIADRLYFEPLTAEDVQSIIELEQPDGAIVQFGGQTAIKLSQDLMKMGVPILGTSADSVDAAEDRERFDEILEKCQIDRPKGQTVFTAEEALKAANELGYPVLVRPSYVLGGAGMEIALNDGDLKRFIDHITSQFNIEDHPILIDKYLAGKECEVDAICDDEGILIPGIMEHVERAGVHSGDSISIYPPQKISQEMKERIVEYSKRLAKALKVKGLMNIQFIVYENKVYVIEVNPRSSRTIPYISKVTGIPLVDVATNVIVGKSIKEQGYDYGLAPEKKTVAVKMPVFSFEKITGAEIALGPEMKSTGEVLGISEDVEEAMYKAFMGTGLDLPKHKKVICTVKDSAKEEFLPIAKEYHDFGYDLYATQGTYDFLQSHGIPARLVNRINDRENTIFDLILTETVDLVIDIPTRNNNLKDGFLIRRFAVEAGVPIYTSLDTARALIHALEAKHDNKISLVDITKL
>NZ_CP018218.1|WP_002880287.1|1313384_1314026_+|tyrosine-type-recombinase/integrase
MGRKVKKTESSRNIRPLKTAKEINAMKRALQFGTGTVTGQNRNGLRNAMIFVFGINTGLRISDIVKAKVSDIEDGEWYNLVETKTHKNRHAYIGNISQDLENYIAQMQLKPSDWLFPSRKGEGHIEGKSFYKDLKRAARQCEIDPNTVGTHTLRKTFGYHYIKSATTPAGDPDPRALYKLQKMLNHSSPTTTLRYIGLEDESMEEDLKSFRLG
>NZ_CP018218.1|WP_002880289.1|1314217_1314688_-|GNAT-family-N-acetyltransferase
MQIRRTQVKDIPAIMKLLSQVLEIHASIRPDIFIPGTTKYTVEELTTIINDDQKAVFVAVDEDDQVLGYAFTQLQEQPFSTNMVQFKSLFIDDLCVDSTQRSQGVGRALLDYIKAEAKRLGCYEVTLNVWEGNDSAINFYKKNGLKVKETNMEFIL
>NZ_CP018218.1|WP_002880291.1|1314992_1315907_+|ABC-transporter-ATP-binding-protein
MKNAIEVRNLSKSYGDLKVVNDISFAVREGELFAFLGPNGAGKSTTVDCLSTLTKFDSGEIKLAGLNMKTQAQEIKQRIGIVFQEGMLDKRLTVLENLTLRAGFYYHSKAEVKAAVARASEYTEINDLLKRQYGKLSGGQRRRVDIARALLNTPKILFLDEPTTGLDPQTRQHIWETIQRLQKEQGMTIFLTTHYMAEASAADYVVILDHGKIVAEGSPISLKERYSYDRLKLYPKKEQNLDNILSSLSLNWNKVADHYEVELRNTMDAIDIVEGMRDQLQSFEVLHGTMDDVFLNITGRRLRE
>NZ_CP018218.1|WP_035176908.1|1315903_1316764_+|ABC-transporter-permease-subunit
MSAMVKRNLKIYFRDKASVFFSMLSVIIIFALYILFIGDSVNSGLKFLPHPNRLMRAWMLAGMLASASITTSLGAYGVMISDRENKAIKDFYSSPVSRRQVAGGYIVTGFIISIIMSIFTLIFGEIYLGLDGGAVLDIETLLKLFAVIVLSAFASSAIASFIISFLKTNSSYSAASTIVGTLIGFLVGAYIPIGSLPDNVQWLVKYFPCAHSAVLYRQLLMKPAIKANFANQPASVLKKIKEILGIVFVYDGHTAPAWVSVAVLLLTGVVFYSLAVLVMTRKQNEI

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Crispr_ID: NZ_CP018218_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018218_3

1460446-1460549

Orphan

Consensus_repeat	Method
CCGCTGCCCCCGCACTTGTCACAGGT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP018218_3

>merge|NZ_CP018218|3|1460446-1460549|CRISPRCasFinder
CCGCTGCCCCCGCACTTGTCACAGGTCGTCTGCCGCTGGATTATGCCCAAAACGCTTCTTTGCGTAATGGTCATCATGCCGCTGCCCCCGCACTTGTCGCAGGT

>NZ_CP018218|3|2|1460446-1460549|CRISPRCasFinder
CCGCTGCCCCCGCACTTGTCACAGGT	CGTCTGCCGCTGGATTATGCCCAAAACGCTTCTTTGCGTAATGGTCATCATG
CCGCTGCCCCCGCACTTGTCGCAGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018218.1\|WP_002879875.1\|1445992_1448251_+\|HAD-IC-family-P-type-ATPase	unknown	unknown	gnl\|CDD\|319771
NZ_CP018218.1\|WP_002876681.1\|1451868_1452894_-\|branched-chain-amino-acid-aminotransferase	unknown	unknown	gnl\|CDD\|237363
NZ_CP018218.1\|WP_002876703.1\|1461129_1462974_-\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NZ_CP018218.1\|WP_011678395.1\|1469917_1470196_-\|YlxR-family-protein	unknown	unknown	gnl\|CDD\|377288
NZ_CP018218.1\|WP_002876710.1\|1464846_1465788_-\|riboflavin-biosynthesis-protein-RibF	unknown	unknown	gnl\|CDD\|235536
NZ_CP018218.1\|WP_002876676.1\|1450619_1451753_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP018218.1\|WP_035176395.1\|1453095_1453983_-\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
NZ_CP018218.1\|WP_002876696.1\|1457947_1459786_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP018218.1\|WP_002876684.1\|1454094_1454397_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP018218.1\|WP_002876708.1\|1463662_1464706_-\|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
NZ_CP018218.1\|WP_002876685.1\|1454475_1455003_-\|adenine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235028
NZ_CP018218.1\|WP_002876711.1\|1465802_1466699_-\|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl\|CDD\|235042
NZ_CP018218.1\|WP_002876705.1\|1463033_1463651_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|237631
NZ_CP018218.1\|WP_002876724.1\|1470226_1471378_-\|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl\|CDD\|237061
NZ_CP018218.1\|WP_002878880.1\|1449363_1450413_-\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NZ_CP018218.1\|WP_002876688.1\|1454992_1457269_-\|single-stranded-DNA-specific-exonuclease-RecJ	unknown	unknown	gnl\|CDD\|273193
NZ_CP018218.1\|WP_002876694.1\|1457265_1457967_-\|class-A-sortase	unknown	unknown	gnl\|CDD\|320680
NZ_CP018218.1\|WP_002876720.1\|1469606_1469891_-\|50S-ribosomal-protein-L7ae	unknown	unknown	gnl\|CDD\|180920
NZ_CP018218.1\|WP_002876717.1\|1466749_1467112_-\|ribosome-binding-factor-A	unknown	unknown	gnl\|CDD\|184345
NZ_CP018218.1\|WP_002876719.1\|1467124_1469602_-\|translation-initiation-factor-IF-2	unknown	unknown	gnl\|CDD\|235401

Protein	Function_ID	Function_description	E-value
NZ_CP018218.1\|WP_002879875.1\|1445992_1448251_+\|HAD-IC-family-P-type-ATPase	gnl\|CDD\|319771	cd02076, P-type_ATPase_H, plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases. This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP018218.1\|WP_002876681.1\|1451868_1452894_-\|branched-chain-amino-acid-aminotransferase	gnl\|CDD\|237363	PRK13357, PRK13357, branched-chain amino acid aminotransferase; Provisional.	0
NZ_CP018218.1\|WP_002876703.1\|1461129_1462974_-\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_CP018218.1\|WP_011678395.1\|1469917_1470196_-\|YlxR-family-protein	gnl\|CDD\|377288	pfam04296, DUF448, Protein of unknown function (DUF448).	6.22433e-28
NZ_CP018218.1\|WP_002876710.1\|1464846_1465788_-\|riboflavin-biosynthesis-protein-RibF	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	8.00781e-112
NZ_CP018218.1\|WP_002876676.1\|1450619_1451753_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	3.09826e-43
NZ_CP018218.1\|WP_035176395.1\|1453095_1453983_-\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.29732e-85
NZ_CP018218.1\|WP_002876696.1\|1457947_1459786_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP018218.1\|WP_002876684.1\|1454094_1454397_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	2.51814e-13
NZ_CP018218.1\|WP_002876708.1\|1463662_1464706_-\|heat-inducible-transcriptional-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	3.02491e-123
NZ_CP018218.1\|WP_002876685.1\|1454475_1455003_-\|adenine-phosphoribosyltransferase	gnl\|CDD\|235028	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional.	3.4503e-95
NZ_CP018218.1\|WP_002876711.1\|1465802_1466699_-\|tRNA-pseudouridine(55)-synthase-TruB	gnl\|CDD\|235042	PRK02484, truB, tRNA pseudouridine synthase B; Provisional.	1.26326e-180
NZ_CP018218.1\|WP_002876705.1\|1463033_1463651_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|237631	PRK14162, PRK14162, heat shock protein GrpE; Provisional.	1.75538e-86
NZ_CP018218.1\|WP_002876724.1\|1470226_1471378_-\|transcription-termination/antitermination-protein-NusA	gnl\|CDD\|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	0
NZ_CP018218.1\|WP_002878880.1\|1449363_1450413_-\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	1.36906e-70
NZ_CP018218.1\|WP_002876688.1\|1454992_1457269_-\|single-stranded-DNA-specific-exonuclease-RecJ	gnl\|CDD\|273193	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ. All proteins in this family are 5'-3' single-strand DNA exonucleases. These proteins are used in some aspects of mismatch repair, recombination, and recombinational repair. [DNA metabolism, DNA replication, recombination, and repair].	5.87425e-161
NZ_CP018218.1\|WP_002876694.1\|1457265_1457967_-\|class-A-sortase	gnl\|CDD\|320680	cd06165, Sortase_A, Sortase domain found in class A sortases. Class A sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). They perform a housekeeping role in the cell as members of this group are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is cleaved at a conserved cell wall-sorting signal (Class A sortases recognize a canonical LPXTG motif, X can be any amino acid), and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical sortase A protein from Staphylococcus aureus (named Sa-SrtA) cleaves the amide bond between threonine and glycine residues of the canonical LPXTG motif in a wide range of protein substrates with diverse functions that can promote bacterial adhesion, nutrient acquisition, host cell invasion, and immune evasion. Next, it catalyzes a transpeptidation reaction by which the proteins are covalently linked to the peptidoglycan precursor lipid II. SrtA is therefore affects the ability of a pathogen to establish successful infection. SrtA contains an N-terminal hydrophobic segment, a linker region and an extra-cellular C-terminal catalytic domain. The hydrophobic segment functions as both a signal peptide for secretion and a stop-transfer signal for membrane anchoring. The catalytic domain contains the catalytic TLXTC signature sequence where X is usually a valine, isoleucine or a threonine. The gene encoding SrtA is generally not located in the same gene cluster as its substrates while the gene encoding SrtB is usually clustered in the same locus as its substrate.	1.67884e-58
NZ_CP018218.1\|WP_002876720.1\|1469606_1469891_-\|50S-ribosomal-protein-L7ae	gnl\|CDD\|180920	PRK07283, PRK07283, YlxQ-related RNA-binding protein.	1.20793e-18
NZ_CP018218.1\|WP_002876717.1\|1466749_1467112_-\|ribosome-binding-factor-A	gnl\|CDD\|184345	PRK13818, PRK13818, ribosome-binding factor A; Provisional.	1.03919e-72
NZ_CP018218.1\|WP_002876719.1\|1467124_1469602_-\|translation-initiation-factor-IF-2	gnl\|CDD\|235401	PRK05306, infB, translation initiation factor IF-2; Validated.	0

>NZ_CP018218.1|WP_002876696.1|1457947_1459786_-|elongation-factor-4
MDLEKLKDYQKHIRNFSIVAHVDHGKSTIADRILELTDTVSKRQLKNQMLDDMPLERQRGITIKMNSVQVKYHANDGEDYIFHLIDTPGHVDFSYEVSRSLAACEGAVLVVDASQGVQAQTLSNTYLALENDLEILPVLNKIDLPSADPDMAKSEIGDMLGLDASDAVEVSGKTGAGIPELLERIVTDIPAPTGDLTKPLKALIFDSKYDDYRGVVMSVRIEEGTVKPGDEIMIMNTGKKYEVTEVGVSSPHPVKEDILIAGDVGYITANIKSVRETRVGDTITSAENPTAEALPGYRQIPPMVYSGMYPTDNRDYDDLKEALQKLQLNDASLEFEPETSQALGFGFRCGFLGLLHMDVVQERLEQEFDLDLIMTAPSVDYHAIMPTGEVKLIDNPADLPDAGEYKELQEPYVKAEIMVPNDFVGAVMQLCEGKRGEFQTMDYLDKYRVNVIYEMPLAEIIYNFFDQLKSSTKGYASLDYEIIGYKATNLVKIDILLNKEPIDALSFIAHREEARDRAVQMCSLLKKLIPRQNFQVDIQGAIGSKIISRATIKPYRKDVTWKIHTGDPDRRAKLLEKQKRGKKRMKSVGRVEVPQDAFMAVLRMNDDDINGK
>NZ_CP018218.1|WP_002876694.1|1457265_1457967_-|class-A-sortase
MTSTASKNTKDHPVRRIILRLVAVILFLLGLALVFNQQISAFLVKQNQTAALKGLTRDQVVQNQKKKGMYDFKKVKSIDFAQTTRSRVKNTAGAIGAISIPSVKLYLPVMQGLSDAALSKGGGTMRADQKMGKGNYPLAGHYMTDQGALFSPLERVKLGSMVYLTDLKKVYAYKIYYKKVVDPSAVWLVANTKKKIVTLITCADGGVNRWSLRGKLTAVKPASKQNLEMFKLR
>NZ_CP018218.1|WP_002876688.1|1454992_1457269_-|single-stranded-DNA-specific-exonuclease-RecJ
MKWQERTADPLASDLVEEFQLSPLTAKLFSLRGIDNEEKIDYWLHASENDLADPFLMHDMDKAVGRINQALDEGEKITIYGDYDADGITATAIMTEMLTIMGADVHYFIPDRFKDGYGPSLDRYKDIVADGTKLIITVDNGVTGIEEVAYAQSHGVDVIVTDHHTFKEEKPDAYALVHCNYPGQAYPFDDYCGAGVAYTIARAVLEDTASEFLELAMIGTIGDMVKVSGEGHVIVKRGLEMLNESSRPGLEALIRNAGLTPGMIDEEDVGFSIAPRLNACGRLADASLAVRLLLAESPGEAQELADQIEKLNNERKDLTQATMQAAEAQIKSRGYQKDATLTLYDPAWHEGVMGLVANKIVEKYHKPTLMLTKNEAGLVKGSGRSSQGFNLFNALKPFEGKSITQFGGHDFACGLSTTEENLNQLRRDFNQSYKAGEKAPEKVQEYDGTISPLDVDLTSVYDLAQAGPFGTDNPQPVFLLDKPQISNFRPMRKGCSFMVGPVRAVDFDHGLNQTVLPYLQQMLVKLASNTFKGKTNVQFRIVDLHYGQSLYAPSARIVDFRGQENLLGFADKYLLFDEKNLSQAINHFGITKEQISLAKDNEDLSQQVVSVLDVPANEAQLNFVLAKPYRQLYLRFQLDQLPGETLPSRRNFGLVWQYFLAHPGLKPNDYMQAAGQLGMDPDSIMFILRVFFTLDFVKMEEDRLLPKPSPTKKSLDDSAYYRSVKAEYAFANKLRTISSDELIRYASGLANGGLQNVN
>NZ_CP018218.1|WP_002876685.1|1454475_1455003_-|adenine-phosphoribosyltransferase
MSIDFKKYIASVKDFPNEGIIFRDITPILQDGEAFAAATHELAEYAKSRQADVIVGPEARGFLVGTPVAIELGIGFVPARKPHKLPREVEAAAYDLEYGSNVLEMHKDAIKPGQRVVICDDLMATAGTLHATKELIERLGGKVVGAAFYIELTDLKGREKFPDVDIFSLVQYTGA
>NZ_CP018218.1|WP_002876684.1|1454094_1454397_+|winged-helix-turn-helix-transcriptional-regulator
MTHEEQIDQAARLFKVLGSSLRIHILFYLRKHGESPVSAIVGHLGVSQPVISKQLGILKKYDFVQKRKAGTFVYYSINDQDIVQIIDAMTEHLDHLDRLQ
>NZ_CP018218.1|WP_035176395.1|1453095_1453983_-|cation-transporter
MKDQASKRYLWVTVFNVIITAAEIAGGIISGSLALLSDALHNLSDVVSIVVAFAANLIAKRSKDQHKTFGYKRAETLAAYTNGLFLLAISIYLFISAIKRFSKPEPIEGGVMFIVSLIGLAGNLISMLILGKGSKENLNARALFLNMMSDTLSSVAVVVGSLLIYYQNWTLVDPVLTMAAAIFLLKEAFEVTRDSANVLMEANPDLDLEAIEEAGLAFKEVIQLHHLHVWRYSDDTIMLDAHIVVDSGLTAKRIEELDEEIAACLKEKFAINHVTLQAECSRGLDEDLLSTNKEN
>NZ_CP018218.1|WP_002876681.1|1451868_1452894_-|branched-chain-amino-acid-aminotransferase
MAKKDLDWANIGFGYHQTDKRYVDYFHDGAWEGGKLTDDPNVVLNECAETLQYAQQVFEGMKAYTWKDGSVVVFRPDQNAERMYNSAKRIEMQPYPKDKFVEAIDQVVKGNVDWVPPYGSGATLYLRPYEIGTTPIIGVAPATDYMFRIFATPVGPYYKGGATPVAVQVAQYDRAAPRGTGHVKAALNYAMSLKATVAAHQAGFAENMYLDPATQTYIEETGGSNIIFIDQNNHLVVPKSNSILPSITRRSIVYLAEHYLNLTVEERQVRFDEVPSFKECALVGTAAVLSPVGRIVNGDQVIDLPSGMDKPGKFMEELYNTLTGIQNGEVEAPEGWIHHVM
>NZ_CP018218.1|WP_002876676.1|1450619_1451753_-|AI-2E-family-transporter
MNKFWNHIDQKYFKIALYCLGTVFAGLFILLLAYESTGFWVRVGKILAAIAQPLTYGLVLTYLLLPLTNFFDRKFSKGSSRGAVATASRSAAVALTLLLLLLVILLAATAVFVTFSKQMSHFSLGSLESLYDQLKSQYSSFINEILAYLQKQGWSTSGLVSYMQKGVGRVTGFLSDFFFGVIFAIYFLYDGQQIAAYWKRNLGTLLNKKVIKGIKLFLADADRAFSGYIRGQIIDAFIVGLLVSLAMLIAKVPYGLLIGLVTGLGNLIPYFGPILGYGMVILACTLSQNMTALIVGMIILLLIQAIDGNILNPKLLSSAIHIHPLYVIACVIAGGAMGGFVGMLIAVPIGALLKTEFERLIAYRQKQLEKSKEASEE
>NZ_CP018218.1|WP_002878880.1|1449363_1450413_-|IS30-family-transposase
MDHSYSNTKPHQKGKHLTLNDRTTIQELHSKGYSNRAIARELNCSPSTVGYELKRGTVSLYTGNVRRYKAVEGQSTYELHRSECGRKSLFLRRHKFIDYVSHCFHNQGWSLDACVGYALAKGIFQKDQVVSTKTLYNYVDLGLMDIKNGDLPEKVKRNTKTRRARVNKRILGRSIDERSPRIESRKDFGHWECDLVLGHKTKDDDVLLTLCERKTRQFFMIKIEDKTSASVMKAFDKLREYYGSKWNQIFKSITTDNGSEFADLSNLEQVSKTLVYYAHPYTSCDKGSVERHNGLIRRYIPKGDRMDKYSVEDIAKIEVWCNSLPRKILNYKTPEEYFDTELDRIYRRR
>NZ_CP018218.1|WP_002879875.1|1445992_1448251_+|HAD-IC-family-P-type-ATPase
MKVKGLTQTEADLRLKKDGLNQVPEPEFSFWKEFAGKLWNLSAWILEAALLLECALGKWIQSLFVLLMLLFAAYNGATQKKKSRKVLSSISQQLTPVVAVLRDDRWQKIDSKYLVVGDIVNLQKGDILAADIDLLDGNLTLDESSITGEAKNVHKKAGATAFAGTTVMDGEALGRVSATGTNSRSGQTINLINKSAAPGHLQQLLTKIIYYLCLLDGVLTVILLIAAVIRGENILEMLPFLAMMFIASIPVAMPSTFALSNSFEATRLSKEGVLTSDLTGIQDAANLNLLLLDKTGTITENKTAVASFANFSKLSDEEVLALTSLAIDQRNQSVIDLALMDFLQEKKIPVKEAEAFTPFTSSQGYSEGRGEGHDVKLGSVKQFSKIDPAISEQMAAVDLSLGRSVGILLDDRLAGIFITKDKVRADSKAALAELVKRGIKPVMLTGDNQKTAASVAEEVGLTGKVISISDFKEGVKAEDLAGIADVLPEDKLDMVKYFQKAGYIVGMTGDGVNDSPALKQAEVGIAVSNAADVAKKSSKMVLLDEGLSPIVKILDAGHRVYQRMTTWSLTKLARTAELTMLLTFSYLIFGYLPMALNAMVIYTIMNNMVTMMIGTDKTHITYKPENWDMGKLAKIAFSLAGAWTIIGFAFVSALTKAGVNHDQVGTMVYVFLVMSAMMIVLITRTKRFFWQSAPSKPVASVQIADILLTCLLALLGIAMPAIGIKELLTTLAVAFLAAILIDLVYQPVMKNK
>NZ_CP018218.1|WP_002876703.1|1461129_1462974_-|molecular-chaperone-DnaK
MSKVIGIDLGTTNSVVAVLEGKEPKIITNPEGARTTPSVVAFKDGEIQVGEIAKRQAITNPNTIVSIKRHMGESDYKVKVGDKAYTPQEISAMILQYIKKFSEDYLGEPVTDAVITVPAYFNDAQRQATKDAGKIAGLNVQRIINEPTASALAYGLDKDEDDETVLVYDLGGGTFDVSVLQLGDGVFQVLSTNGDTHLGGDDFDNKIIDWLVDGFKQENGVDLSKDKMAMQRLKDAAEKAKKDLSGVSSTHISLPFISAGEAGPLHLEADLTRAKFNELTDDLVQRTKIPFDNALRDAGLSVGDIDKVILNGGSTRIPAIQEAVKQWAGKEPDHSINPDEAVALGAAIQGGVISGDVKDIVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQIFSTAADNQSAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGVPQIQVTFDIDKNGIVNVSAKDMGTGKEQKITIQSASGLSDEEIERMKKEAEEHAEEDAKKKEEVDLRNEVDGLIFQTEKTLKEVDGKLADSDIQPVKDALEDLKKAQKDNNLDEMKEKKDALSKVAQDLAVKLYQQNAQNQQGQGGQAGPTDDGSNGANGDTVDGDFTKVDPDK
>NZ_CP018218.1|WP_002876705.1|1463033_1463651_-|nucleotide-exchange-factor-GrpE
MSKEEFPIEKDLPQEDQEKQAKSAEADKAGVKDDKKVKDDKEEAAKPADVELDQLKAEVAALTQKNKDLEDKYLRSQAEIQNAQRRYSKERANLVKYESQRLGKDILSSVDNLERALQVKADDEASRQLKKGIEMTLEGLVRALKDNGIEEIKADGEKFDPTLHQAVQSVPAENDDQKGHVVQVLQKGYVYKDRVLRPAMVVVAQ
>NZ_CP018218.1|WP_002876708.1|1463662_1464706_-|heat-inducible-transcriptional-repressor-HrcA
MLTERQELILKTIIQDFTKTHEPVGSKTVMNQLPIKVSSATIRNEMAVLEEHSLIEKTHSSSGRMPSTEGYRYYLDNLVQPLQLPEEMYNQIGYQFDQPFNQVDEIIKEAAKILSDLTDYTAFAEGPEAKNVSVTGFRIVPLAPRQVMAILVTSDGSVKNQIYALPRHISGDEIEQVVRLINDQLVGKNLSEINKQTFDQLSSSQIVGKNAPEFLEFLEAVIKDAESEQMYVDGQLNLLNNTEISDLKAIKSLYELINSSSLAGELIELSDSPSHYPVHVRLGAELENDLLKDFSLVTAEYSVGRYGRGTISLLGPRHMPYSEMIGLMEYFRQELARKLLDYYGRFK
>NZ_CP018218.1|WP_002876710.1|1464846_1465788_-|riboflavin-biosynthesis-protein-RibF
MKVINLSYPFKKELTAGKVVLALGFFDGVHIGHQKLIKEAKIIAVEKDLPLMVLTFDRHPKEVYAGVKDFEYLNTPEEKAYEMSKIGVDYLVILKFTPEFSHLAPQAFVDEIIMGLKADTVVAGFDYSYGPKDVANMENLPAFAKGRFDIKVVPKQIFAGKKIGSTEIRQAVKSGNLRLATELLGHPYLTSGKVVHGFRNGHKLGFPTANLELDWPKVLPKIGVYATMTQVGDRWYQSMTSVGYNVTFNDEKKIYIESNIFDFDQDIYGQQITIAWYKYLRGEEKFADMAALSEQLKLDQVASENYFSSLIEQ
>NZ_CP018218.1|WP_002876711.1|1465802_1466699_-|tRNA-pseudouridine(55)-synthase-TruB
MFNGIIVIDKAAGMTSGDVVYKLRRLLKQKKIGHAGTLDPEVTGVLPIALGQATKLIELMHERPKAYVGEGMLGLATDSYDLEGKILAERALSQPVSDQAIKAAMEKFTGEIVQQPPIYSAVRVNGKRLYEYAREGIPVERPKRTVQVFRYDLTAPSQFDPEKGRQTFTYEVECSKGTYVRSLVNDLGEELGLPAVMTKLRRTASSGYKLQDAVTLEELADNLNHAKDYIQPIDSFFADYQQVDLDADLWQQVKNGAWIKLPLNADKVALRYNKTVKAIYRAKGQGLYCPDLMLLSNE
>NZ_CP018218.1|WP_002876717.1|1466749_1467112_-|ribosome-binding-factor-A
MKHRKGRVEGEILRELTKIIRKNIRDPRVSNVTFTAVECSNDFSYATVYYSLLTEDEQAQKEAEAGLEKAKGTMRHLLGQSLTMYKVPELIFKRDQSVIYGSKIDRLLADLKKQEQDRQN
>NZ_CP018218.1|WP_002876719.1|1467124_1469602_-|translation-initiation-factor-IF-2
MTKKQENESSKELGMDNKKTSGKSGKIKISVSAIRKGEKKTEGKRSNTRRRANNHSNDHSKRRRPAAQDLLKDLKQKQRADEARLDQESKAAKHEYKKSLNKAEASESKPVVKKVESAEKPAETAAEAPKVRGPKILKPSPARLKQNQANSEKPAAKPSSSRRSSSRPSFTEAPMPENKEGRRRKSGKPGRKGQNSYANQGRGANSDRSQQRKRKNKKHQSAPQVKKQVTQRKERPLPESFEYEVGMNAQDLGKILHREPAEIVKKLFMLGIMINQNQSLDKGTIELLAADYGIEAVEKVHEDISDIDNIFAQEMEESKNSENQVVRPPVVTIMGHVDHGKTTLLDRLRHTRVSEHEAGGITQNIGAYQVRINDRLITFLDTPGHAAFSSMRARGAEITDIVVLIVAADDGVMPQTIEAIDHAKSAGVPIIVAINKMDRPGANPAHVTEQLMQYELIPENYGGSTIFVNISAKTGMGIDELLENIILEADMLELKADPKQKAIGTVIEARLSRGKGPVADVLIQQGTLRVGDPIVVGDTFGRVRTMTNDKGHQVKKATPSMPVEITGLNDVPESADKLVVFADEKTARAVGEARAQQSLQKQRENVQHVTLDNLFDTMKRESMKSVDIVLKADVQGSAEALAQSLQKIDVEGVRVNIIHSGVGAINESDVTLASASNALIIGFNVRPTATAKSQAAQEGVDIRLYSIIYKAIDDVKAAMQGMLEPTYEEKVIGNLTVRETWKVSKIGTIAGAFVDNGYVTRESGIRVIRDGVVKYDGKVASLRRFKDDVKEVKAGFDCGLTIENFNDIKEGDELEAYEMQEVKPG
>NZ_CP018218.1|WP_002876720.1|1469606_1469891_-|50S-ribosomal-protein-L7ae
MLGLATRAGKTVSGTDIVLAKLKKGKLKCIIIANDLAENSRGKIEAAVKAHPTPLVDVFTEAELSQAVGKKRKVLALTDRGFAKTLLDKIKEGV
>NZ_CP018218.1|WP_011678395.1|1469917_1470196_-|YlxR-family-protein
MRKDLLTDTMQPKKDLVRIVVDKEKNVSVDPSGKKPGRGAYVSLKPEKIAAARKSKVLERSLGVKVADEFYDELFAYVDHQKARKELFGDQK
>NZ_CP018218.1|WP_002876724.1|1470226_1471378_-|transcription-termination/antitermination-protein-NusA
MSKEMLEAFDVLEKTKGIKQDVIVEAMKAALAAAYKKNYGLAENVEIDFNEKKGDFKVMALKTVVDEVQDDRVEVSLKDALAINRAYEVGDTIKFEVTPKDFGRTAAATAKQVVMQRLREAENAHIVNEYSQYEDELVTGTVERTDNRFVYVNIGNVEAVMDIKRDTIPGEHYNPQDRVRVLVTKVGADGKGAQIRVSRTAPDVVKRLFEQEVPEIFDGTVEIISIAREAGERTKIAVKSNDPNIDPVGTCVGPRGSRVQNVVNELGGENIDIVQYEEDPSDYIANALNPAEVIAVQFEDEDDERKAFVIVPDYQLSLAIGKKGQNVRLAARLTGYKIDIRPESEVEFVDESEVEDETEVAEDQDLQQTEAEEAEDLDLDDEE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP018218_1	1.10\|1132826\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132826-1132855	30	NZ_MF191707	Lactobacillus delbrueckii strain BioLb89 plasmid p89, complete sequence	5107-5136	1	0.967
NZ_CP018218_1	1.10\|1132826\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132826-1132855	30	NC_010909	Lactobacillus delbrueckii subsp. bulgaricus plasmid pDOJ1, complete sequence	5274-5303	1	0.967
NZ_CP018218_1	1.10\|1132826\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132826-1132855	30	NC_014728	Lactobacillus delbrueckii subsp. bulgaricus ND02 plasmid unnamed, complete sequence	5274-5303	1	0.967
NZ_CP018218_1	1.10\|1132826\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132826-1132855	30	NC_004937	Lactobacillus delbrueckii subsp. lactis plasmid pLL1212, complete plasmid sequence	4885-4914	1	0.967
NZ_CP018218_1	1.10\|1132826\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132826-1132855	30	NC_002191	Lactobacillus delbrueckii subsp. bulgaricus plasmid pLBB1, complete plasmid sequence	5178-5207	1	0.967
NZ_CP018218_1	1.10\|1132826\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132826-1132855	30	CP029251	Lactobacillus delbrueckii subsp. lactis isolate NWC_1_2 plasmid p1, complete sequence	3059-3088	1	0.967
NZ_CP018218_1	1.10\|1132826\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132826-1132855	30	CP031024	Lactobacillus delbrueckii subsp. lactis isolate NWC_2_2 plasmid pNWC_2_2, complete sequence	4282-4311	1	0.967
NZ_CP018218_1	1.10\|1132826\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132826-1132855	30	NC_004849	Lactobacillus delbrueckii subsp. lactis plasmid pJBL2	7514-7543	1	0.967
NZ_CP018218_1	1.10\|1132826\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132826-1132855	30	NC_004850	Lactobacillus delbrueckii subsp. lactis plasmid pN42	7201-7230	1	0.967
NZ_CP018218_1	1.2\|1132297\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132297-1132326	30	NZ_CP027671	Simplicispira suum strain SC1-8 plasmid unnamed2, complete sequence	34498-34527	6	0.8
NZ_CP018218_1	1.6\|1132562\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132562-1132591	30	NZ_CP040721	Rhodococcus pyridinivorans strain YF3 plasmid unnamed2, complete sequence	142075-142104	7	0.767
NZ_CP018218_1	1.6\|1132562\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132562-1132591	30	NZ_CP018064	Rhodococcus sp. 2G plasmid p1, complete sequence	136796-136825	7	0.767
NZ_CP018218_1	1.8\|1132694\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132694-1132723	30	NZ_LR594663	Variovorax sp. RA8 plasmid 2	238939-238968	7	0.767
NZ_CP018218_1	1.10\|1132826\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132826-1132855	30	NZ_CP023400	Pseudoalteromonas spongiae strain SAO4-4 plasmid pl, complete sequence	138789-138818	7	0.767
NZ_CP018218_1	1.3\|1132363\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132363-1132392	30	NZ_CP049040	Pseudohalocynthiibacter aestuariivivens strain RR4-35 plasmid pRR4-35_3, complete sequence	71690-71719	8	0.733
NZ_CP018218_1	1.10\|1132826\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132826-1132855	30	KP063541	Enterobacteria phage P88, complete genome	10483-10512	8	0.733
NZ_CP018218_1	1.1\|1132231\|30\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132231-1132260	30	MT774390	CrAssphage cr85_1, complete genome	53988-54017	9	0.7
NZ_CP018218_1	1.4\|1132429\|31\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132429-1132459	31	AP014476	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5C-MedDCM-OCT-S42-C91, * SEQUENCING IN PROGRESS *, 2 ordered pieces	13764-13794	9	0.71
NZ_CP018218_1	1.4\|1132429\|31\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132429-1132459	31	AP013944	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5C-MedDCM-OCT-S41-C114, * SEQUENCING IN PROGRESS *	12564-12594	9	0.71
NZ_CP018218_1	1.4\|1132429\|31\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132429-1132459	31	MK448727	Streptococcus phage Javan291, complete genome	1450-1480	9	0.71
NZ_CP018218_1	1.4\|1132429\|31\|NZ_CP018218\|PILER-CR,CRISPRCasFinder,CRT	1132429-1132459	31	AP013945	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5C-MedDCM-OCT-S43-C137, * SEQUENCING IN PROGRESS *	8033-8063	9	0.71

1. spacer 1.10|1132826|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NZ_MF191707 (Lactobacillus delbrueckii strain BioLb89 plasmid p89, complete sequence) position: , mismatch: 1, identity: 0.967

tctagcaagagagaagtgacagacaagctt	CRISPR spacer
tctagcaagagagaagtgacggacaagctt	Protospacer
********************.*********

2. spacer 1.10|1132826|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NC_010909 (Lactobacillus delbrueckii subsp. bulgaricus plasmid pDOJ1, complete sequence) position: , mismatch: 1, identity: 0.967

tctagcaagagagaagtgacagacaagctt	CRISPR spacer
tctagcaagagagaagtgacggacaagctt	Protospacer
********************.*********

3. spacer 1.10|1132826|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NC_014728 (Lactobacillus delbrueckii subsp. bulgaricus ND02 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.967

tctagcaagagagaagtgacagacaagctt	CRISPR spacer
tctagcaagagagaagtgacggacaagctt	Protospacer
********************.*********

4. spacer 1.10|1132826|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NC_004937 (Lactobacillus delbrueckii subsp. lactis plasmid pLL1212, complete plasmid sequence) position: , mismatch: 1, identity: 0.967

tctagcaagagagaagtgacagacaagctt	CRISPR spacer
tctagcaagagagaagtgacggacaagctt	Protospacer
********************.*********

5. spacer 1.10|1132826|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NC_002191 (Lactobacillus delbrueckii subsp. bulgaricus plasmid pLBB1, complete plasmid sequence) position: , mismatch: 1, identity: 0.967

tctagcaagagagaagtgacagacaagctt	CRISPR spacer
tctagcaagagagaagtgacggacaagctt	Protospacer
********************.*********

6. spacer 1.10|1132826|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to CP029251 (Lactobacillus delbrueckii subsp. lactis isolate NWC_1_2 plasmid p1, complete sequence) position: , mismatch: 1, identity: 0.967

tctagcaagagagaagtgacagacaagctt	CRISPR spacer
tctagcaagagagaagtgacggacaagctt	Protospacer
********************.*********

7. spacer 1.10|1132826|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to CP031024 (Lactobacillus delbrueckii subsp. lactis isolate NWC_2_2 plasmid pNWC_2_2, complete sequence) position: , mismatch: 1, identity: 0.967

tctagcaagagagaagtgacagacaagctt	CRISPR spacer
tctagcaagagagaagtgacggacaagctt	Protospacer
********************.*********

8. spacer 1.10|1132826|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NC_004849 (Lactobacillus delbrueckii subsp. lactis plasmid pJBL2) position: , mismatch: 1, identity: 0.967

tctagcaagagagaagtgacagacaagctt	CRISPR spacer
tctagcaagagagaagtgacggacaagctt	Protospacer
********************.*********

9. spacer 1.10|1132826|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NC_004850 (Lactobacillus delbrueckii subsp. lactis plasmid pN42) position: , mismatch: 1, identity: 0.967

tctagcaagagagaagtgacagacaagctt	CRISPR spacer
tctagcaagagagaagtgacggacaagctt	Protospacer
********************.*********

10. spacer 1.2|1132297|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027671 (Simplicispira suum strain SC1-8 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.8

acgccaatggcaatcacaattaccttcttg	CRISPR spacer
acgccaatcgcaatcacaatcacaatcacg	Protospacer
******** ***********.**  ** .*

11. spacer 1.6|1132562|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040721 (Rhodococcus pyridinivorans strain YF3 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.767

tcggcatccctgacgctcaaaccctttacc	CRISPR spacer
tcggcatccctgaccctcaaaaccccggct	Protospacer
************** ****** **.. .*.

12. spacer 1.6|1132562|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018064 (Rhodococcus sp. 2G plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.767

tcggcatccctgacgctcaaaccctttacc	CRISPR spacer
tcggcatccctgaccctcaaaacccaggct	Protospacer
************** ****** **.  .*.

13. spacer 1.8|1132694|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR594663 (Variovorax sp. RA8 plasmid 2) position: , mismatch: 7, identity: 0.767

gaccttcgaaaagttgtagtcacggtcttc	CRISPR spacer
tctctgggaaaagttgtattcgcggtcttc	Protospacer
  .**  *********** **.********

14. spacer 1.10|1132826|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023400 (Pseudoalteromonas spongiae strain SAO4-4 plasmid pl, complete sequence) position: , mismatch: 7, identity: 0.767

tctagcaagagagaagtgacagacaagctt	CRISPR spacer
tgccaaaagagagaagtgacagagcagctt	Protospacer
* . . *****************  *****

15. spacer 1.3|1132363|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049040 (Pseudohalocynthiibacter aestuariivivens strain RR4-35 plasmid pRR4-35_3, complete sequence) position: , mismatch: 8, identity: 0.733

gccacgctatccgcaaggttcgggaatgca	CRISPR spacer
gggacgcaatccgcaaggctcgggaaattt	Protospacer
*  **** **********.*******  .

16. spacer 1.10|1132826|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to KP063541 (Enterobacteria phage P88, complete genome) position: , mismatch: 8, identity: 0.733

tctagcaagagagaagtgacagacaagctt	CRISPR spacer
attatcaggagagaagtgacagacaaaaag	Protospacer
 .** **.******************.

17. spacer 1.1|1132231|30|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to MT774390 (CrAssphage cr85_1, complete genome) position: , mismatch: 9, identity: 0.7

tacattgactaggtcatcccacaacttgga	CRISPR spacer
aacattgaatagttcatcccacaaagcaag	Protospacer
 ******* *** ***********  ....

18. spacer 1.4|1132429|31|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to AP014476 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5C-MedDCM-OCT-S42-C91, *** SEQUENCING IN PROGRESS ***, 2 ordered pieces) position: , mismatch: 9, identity: 0.71

cggaattgccgttgctgtcgacatgggcaaa	CRISPR spacer
tcgtgatgccgttgctgtcgaaatgagcacg	Protospacer
. * . *************** ***.*** .

19. spacer 1.4|1132429|31|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to AP013944 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5C-MedDCM-OCT-S41-C114, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.71

cggaattgccgttgctgtcgacatgggcaaa	CRISPR spacer
tcgtgatgccgttgctgtcgaaatgagcacg	Protospacer
. * . *************** ***.*** .

20. spacer 1.4|1132429|31|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to MK448727 (Streptococcus phage Javan291, complete genome) position: , mismatch: 9, identity: 0.71

cggaattgccgttgctgtcgacatgggcaaa	CRISPR spacer
tgtaattgccgttgctgtcaacagggaatcg	Protospacer
.* ****************.*** **.   .

21. spacer 1.4|1132429|31|NZ_CP018218|PILER-CR,CRISPRCasFinder,CRT matches to AP013945 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C5C-MedDCM-OCT-S43-C137, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.71

cggaattgccgttgctgtcgacatgggcaaa	CRISPR spacer
tcgtgatgccgttgctgtcgaaatgagcacg	Protospacer
. * . *************** ***.*** .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

182025 : 192450

Clostridioides_phage(20.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002880125.1\|182025_182802_-	cell wall-associated hydrolase	A0A1V0DZX6	Clostridioides_phage	1.1e-07	36.9
WP_002880123.1\|182847_183603_-	C40 family peptidase	A0A0A8WF62	Clostridium_phage	6.7e-15	40.0
WP_002880122.1\|183895_184609_-	C40 family peptidase	A0A0A7DMV4	Lactobacillus_phage	1.0e-17	52.9
WP_072557688.1\|184972_186196_+\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	8.7e-97	48.5
WP_002879477.1\|186420_187203_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	2.6e-14	42.7
WP_002879478.1\|187390_187864_-	C40 family peptidase	A0A1V0DZX6	Clostridioides_phage	2.7e-14	38.0
WP_002879479.1\|188034_189081_-	lactate dehydrogenase	M1H502	Paramecium_bursaria_Chlorella_virus	7.3e-28	29.7
WP_002879480.1\|189364_189850_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	4.3e-15	39.7
WP_002879481.1\|189957_190500_-	AAA family ATPase	U5J9X2	Bacillus_phage	2.2e-12	35.4
WP_002879482.1\|190589_190919_+	DUF2187 domain-containing protein	NA	NA	NA	NA
WP_002879483.1\|191169_192450_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A0P0IJS6	Lactobacillus_phage	1.8e-105	50.8

DBSCAN-SWA_2

250587 : 285387

unidentified_phage(25.0%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002878880.1\|250587_251637_+\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	6.6e-53	35.2
WP_072557689.1\|251971_253225_-\|transposase	transposase	NA	NA	NA	NA
WP_072557690.1\|253175_253541_-	hypothetical protein	NA	NA	NA	NA
WP_072557691.1\|253537_254164_-\|transposase	IS607 family transposase	A0A7Q0	Microcystis_virus	5.1e-45	48.2
WP_133281435.1\|254257_254611_+	hypothetical protein	NA	NA	NA	NA
WP_002878959.1\|255059_256478_-	DASS family sodium-coupled anion symporter	NA	NA	NA	NA
WP_002878957.1\|256503_257907_-	class II fumarate hydratase	NA	NA	NA	NA
WP_072557692.1\|258520_259894_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_002877134.1\|260069_260825_-	DUF4430 domain-containing protein	NA	NA	NA	NA
WP_002877136.1\|260859_261906_-	hypothetical protein	NA	NA	NA	NA
WP_080638353.1\|263711_263915_+	hypothetical protein	NA	NA	NA	NA
WP_002879463.1\|265264_265504_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_002879460.1\|266282_267197_+	hypothetical protein	NA	NA	NA	NA
WP_002879459.1\|267255_267495_-	hypothetical protein	NA	NA	NA	NA
WP_002879458.1\|267591_268092_-	O-acetyl-ADP-ribose deacetylase	F1SVT2	Red_sea_bream_iridovirus	9.2e-37	47.6
WP_002879454.1\|268091_268874_-	tyrosine-protein phosphatase	NA	NA	NA	NA
WP_002879453.1\|268985_269756_-	tyrosine-protein phosphatase	NA	NA	NA	NA
WP_002879452.1\|269789_271298_-	glycerol kinase GlpK	NA	NA	NA	NA
WP_002879450.1\|271494_272163_+	hypothetical protein	NA	NA	NA	NA
WP_072557693.1\|272289_272526_+	transcriptional regulator	NA	NA	NA	NA
WP_072547936.1\|272623_272860_+	transcriptional regulator	NA	NA	NA	NA
WP_002876617.1\|272983_275074_+\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	4.6e-122	39.0
WP_052001639.1\|275976_276480_-	hypothetical protein	NA	NA	NA	NA
WP_002876619.1\|276486_276735_-	branched-chain amino acid transporter	NA	NA	NA	NA
WP_002876620.1\|277154_277478_-	AzlD domain-containing protein	NA	NA	NA	NA
WP_002876623.1\|277461_278172_-	AzlC family ABC transporter permease	NA	NA	NA	NA
WP_002876624.1\|278269_279181_-	EamA family transporter	NA	NA	NA	NA
WP_002876625.1\|279334_280084_-	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	NA	NA	NA	NA
WP_002876627.1\|280085_280895_-	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_002876630.1\|280959_281835_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_002876631.1\|281827_283138_-	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_002876634.1\|283680_285387_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	NA	NA	NA	NA

DBSCAN-SWA_3

589370 : 650207

Planktothrix_phage(14.29%)

protease,tRNA,transposase,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002877898.1\|589370_590636_+\|tRNA	tyrosine--tRNA ligase	K4F5T3	Cronobacter_phage	5.1e-84	41.9
WP_002877198.1\|592503_592686_+	cytochrome c551	NA	NA	NA	NA
WP_072557700.1\|593144_593300_-\|transposase	transposase	NA	NA	NA	NA
WP_002877201.1\|593466_594117_+	HD domain-containing protein	NA	NA	NA	NA
WP_002877209.1\|595720_597349_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_002877213.1\|597613_599242_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_002877214.1\|599470_601117_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_002877215.1\|601542_602463_+	ABC transporter permease	NA	NA	NA	NA
WP_002877216.1\|602484_603516_+	ABC transporter permease	NA	NA	NA	NA
WP_002877218.1\|603529_604573_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.7e-19	32.2
WP_002877224.1\|604587_605541_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.6e-21	33.8
WP_002877226.1\|605889_607203_-	Aminopeptidase E	R4TV59	Phaeocystis_globosa_virus	3.3e-62	32.5
WP_002877228.1\|607255_608569_-	aminopeptidase	R4TV59	Phaeocystis_globosa_virus	1.2e-62	33.3
WP_002877230.1\|608665_609079_-	Hsp20/alpha crystallin family protein	NA	NA	NA	NA
WP_002877232.1\|609305_609767_+	transcription elongation factor GreA	NA	NA	NA	NA
WP_002877233.1\|609850_611140_-	adenylosuccinate synthase	L7Y4J5	Megavirus	3.5e-72	37.8
WP_035176450.1\|611325_612318_+	GMP reductase	Q4ZCY7	Staphylococcus_virus	7.2e-134	68.7
WP_002877239.1\|614001_615294_-	purine permease	Q9KX94	Enterobacteria_phage	6.3e-29	30.6
WP_002877242.1\|615323_615893_-	xanthine phosphoribosyltransferase	NA	NA	NA	NA
WP_002877243.1\|616247_617405_+	guanosine monophosphate reductase	A0A1V0SHK8	Klosneuvirus	1.9e-61	32.4
WP_002877245.1\|617404_618958_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	4.6e-18	29.7
WP_002877247.1\|619102_620713_+	ABC transporter ATP-binding protein	A0A076FI99	Aureococcus_anophage	5.3e-17	26.9
WP_002877248.1\|620749_621592_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_002877249.1\|621748_623221_+	glycoside hydrolase family 1 protein	A0A0B5JD41	Pandoravirus	1.8e-24	24.5
WP_002877258.1\|623553_623769_-	hypothetical protein	NA	NA	NA	NA
WP_072557701.1\|624022_625246_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	6.6e-97	48.7
WP_002876658.1\|625527_626340_-	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_002876657.1\|626391_627141_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	6.6e-31	38.4
WP_035161049.1\|627137_627848_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_002876654.1\|628268_629033_+	nucleoside phosphorylase	F5CA76	Streptococcus_phi-m46.1-like_phage	2.7e-40	50.3
WP_002876652.1\|629112_630375_-	hypothetical protein	NA	NA	NA	NA
WP_002876649.1\|630468_631434_-	hypothetical protein	A0A1B3AYT3	Gordonia_phage	3.3e-06	32.5
WP_002876648.1\|631584_632979_-	amino acid permease	NA	NA	NA	NA
WP_002876647.1\|633056_633989_+	homocysteine S-methyltransferase	NA	NA	NA	NA
WP_002876645.1\|634557_635004_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_003616833.1\|634985_636008_+	asparaginase	NA	NA	NA	NA
WP_133281431.1\|636107_636935_+	HAD family phosphatase	NA	NA	NA	NA
WP_002876640.1\|637020_637497_+	large conductance mechanosensitive channel protein MscL	NA	NA	NA	NA
WP_072557702.1\|637766_638990_+\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	2.1e-95	48.0
WP_035160951.1\|639234_640668_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	1.5e-103	45.3
WP_002878752.1\|640736_641291_-	cysteine hydrolase	G3MA16	Bacillus_virus	4.0e-33	39.1
WP_002878751.1\|641543_642401_+	hypothetical protein	NA	NA	NA	NA
WP_002878750.1\|642393_642660_-	DUF1294 domain-containing protein	NA	NA	NA	NA
WP_002878749.1\|642754_643525_-	NUDIX hydrolase	G3MA14	Bacillus_virus	2.3e-10	26.2
WP_133281440.1\|643700_643874_+\|bacteriocin	ComC/BlpC family leader-containing pheromone/bacteriocin	NA	NA	NA	NA
WP_035176620.1\|643887_645192_+	GHKL domain-containing protein	NA	NA	NA	NA
WP_133281441.1\|645193_645979_+	response regulator transcription factor	NA	NA	NA	NA
WP_002878746.1\|646131_646419_+\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_002878745.1\|646606_646858_+	hypothetical protein	NA	NA	NA	NA
WP_002878742.1\|647613_648414_-	ABC-2 transporter permease	NA	NA	NA	NA
WP_002878739.1\|648410_649121_-	ATP-binding cassette domain-containing protein	A0A2R8FG22	Brazilian_cedratvirus	3.0e-17	32.8
WP_002878737.1\|649538_650207_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_4

1079000 : 1090580

Streptococcus_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002879207.1\|1079000_1080902_+	DEAD/DEAH box helicase	D2J050	Enterococcus_phage	2.9e-107	46.8
WP_002879208.1\|1081114_1081678_+	TIGR01440 family protein	NA	NA	NA	NA
WP_002879209.1\|1081773_1082172_+	UTRA domain-containing protein	NA	NA	NA	NA
WP_072557712.1\|1082375_1083425_+\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	7.3e-52	34.9
WP_002877626.1\|1083499_1084273_-	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	1.1e-76	56.4
WP_002877618.1\|1084286_1085534_-	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	2.5e-139	63.0
WP_002877611.1\|1085572_1086649_-	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	7.1e-127	66.4
WP_002877609.1\|1086765_1086966_-	YjzD family protein	NA	NA	NA	NA
WP_002877607.1\|1087100_1090580_+	DNA polymerase III subunit alpha	R4TB75	Streptomyces_phage	2.2e-105	29.9

DBSCAN-SWA_5

1214517 : 1262769

Bacillus_phage(12.5%)

tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002878599.1\|1214517_1215816_+\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	1.4e-52	28.4
WP_002878410.1\|1215906_1216554_+	DnaD domain protein	A0A0N7AE27	Bacillus_phage	1.0e-08	38.4
WP_002878412.1\|1216575_1217205_+	endonuclease III	NA	NA	NA	NA
WP_002878414.1\|1217239_1218043_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_035176567.1\|1218077_1218986_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_072557716.1\|1219048_1220098_-\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	7.3e-52	34.9
WP_002876862.1\|1220395_1221397_-	D-2-hydroxyacid dehydrogenase	M1HKI4	Acanthocystis_turfacea_Chlorella_virus	1.7e-37	34.2
WP_002876861.1\|1221445_1223374_-	S9 family peptidase	NA	NA	NA	NA
WP_002876860.1\|1223520_1225833_-	penicillin-binding protein 1A	NA	NA	NA	NA
WP_002876859.1\|1225819_1226452_-	Holliday junction resolvase RecU	A0A1C8E9C3	Bacillus_phage	4.4e-20	33.1
WP_002876858.1\|1226612_1227173_+	DUF1273 domain-containing protein	NA	NA	NA	NA
WP_002876857.1\|1227248_1227713_+	DivIVA domain-containing protein	NA	NA	NA	NA
WP_002876856.1\|1228230_1229355_+	class I SAM-dependent RNA methyltransferase	NA	NA	NA	NA
WP_035176404.1\|1229364_1230597_+	serine/threonine protein phosphatase	NA	NA	NA	NA
WP_002876851.1\|1230751_1231108_+	hypothetical protein	NA	NA	NA	NA
WP_002876848.1\|1231100_1232780_+	formate--tetrahydrofolate ligase	NA	NA	NA	NA
WP_002876847.1\|1232791_1233244_+	signal peptidase II	NA	NA	NA	NA
WP_002876845.1\|1233245_1234160_+	RluA family pseudouridine synthase	A0A2H4UV25	Bodo_saltans_virus	1.9e-08	27.5
WP_002876844.1\|1234161_1235217_+	carbamoyl phosphate synthase small subunit	NA	NA	NA	NA
WP_002876843.1\|1235216_1238408_+	carbamoyl phosphate synthase large subunit	NA	NA	NA	NA
WP_002876842.1\|1238501_1238783_+	ACT domain-containing protein	NA	NA	NA	NA
WP_002876840.1\|1238782_1240126_+	PFL family protein	NA	NA	NA	NA
WP_002876831.1\|1240192_1241884_-	fibronectin/fibrinogen-binding protein	A0A1J0F9J4	Only_Syngen_Nebraska_virus	1.9e-09	45.2
WP_002878426.1\|1242035_1242497_-\|transposase	IS200/IS605 family transposase	A0A0P0IQC6	Lactobacillus_phage	8.2e-40	58.1
WP_072557717.1\|1242563_1243976_+\|transposase	transposase	A0A2I7RKG5	Vibrio_phage	1.4e-10	34.0
WP_002879161.1\|1244318_1245200_+	DegV family protein	NA	NA	NA	NA
WP_002879162.1\|1245255_1246329_+	hypothetical protein	NA	NA	NA	NA
WP_002879163.1\|1246383_1247295_-	EamA family transporter	NA	NA	NA	NA
WP_002879167.1\|1248694_1249777_-	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	2.1e-78	44.2
WP_002879168.1\|1250120_1250744_+	histidine phosphatase family protein	NA	NA	NA	NA
WP_002879169.1\|1250802_1251153_-	ABC transporter permease	NA	NA	NA	NA
WP_002879170.1\|1251337_1251856_-	nitroreductase family protein	A0A1V0E011	Clostridioides_phage	6.4e-09	30.4
WP_002879171.1\|1252259_1253270_+	aspartate carbamoyltransferase catalytic subunit	A0A1J0F9B8	Only_Syngen_Nebraska_virus	9.9e-22	29.8
WP_002879172.1\|1253269_1254553_+	dihydroorotase	NA	NA	NA	NA
WP_002878880.1\|1254628_1255678_-\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	6.6e-53	35.2
WP_002878488.1\|1255873_1256950_-	tyrosine recombinase XerS	NA	NA	NA	NA
WP_002878489.1\|1257182_1258331_+	glycerate kinase	W6LM47	Streptococcus_phage	3.1e-40	34.8
WP_002878491.1\|1258469_1259675_+	DUF2325 domain-containing protein	NA	NA	NA	NA
WP_002878492.1\|1259698_1260277_+	sel1 repeat family protein	NA	NA	NA	NA
WP_072557718.1\|1260828_1262241_-\|transposase	transposase	A0A2I7RKG5	Vibrio_phage	1.4e-10	34.0
WP_003611707.1\|1262307_1262769_+\|transposase	IS200/IS605 family transposase	A0A0P0IQC6	Lactobacillus_phage	4.8e-40	58.1

DBSCAN-SWA_6

1369298 : 1429111

Vibrio_phage(15.79%)

protease,tRNA,transposase,integrase

attL 1367735:1367752|attR 1394156:1394173

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1367735:1367752	attL	NA	NA	NA	NA
WP_002878408.1\|1369298_1370597_+\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	2.8e-53	28.6
WP_002878600.1\|1370660_1371251_-	sugar O-acetyltransferase	NA	NA	NA	NA
WP_002878601.1\|1371586_1372423_+\|integrase	integrase	NA	NA	NA	NA
WP_002878602.1\|1372466_1373033_+	signal peptidase I	NA	NA	NA	NA
WP_002878604.1\|1373102_1373294_+	hypothetical protein	NA	NA	NA	NA
WP_002878607.1\|1373680_1374919_-	peptidase T	NA	NA	NA	NA
WP_002878608.1\|1374962_1375760_-	Nif3-like dinuclear metal center hexameric protein	NA	NA	NA	NA
WP_002878610.1\|1375752_1376445_-	SAM-dependent methyltransferase	NA	NA	NA	NA
WP_002878612.1\|1376589_1377030_+	8-oxo-dGTP diphosphatase	NA	NA	NA	NA
WP_002878613.1\|1377029_1377836_+	M23 family metallopeptidase	NA	NA	NA	NA
WP_133281424.1\|1378386_1379868_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_002878617.1\|1380149_1381934_-	DUF2075 domain-containing protein	NA	NA	NA	NA
WP_133281423.1\|1382077_1382500_-	hypothetical protein	NA	NA	NA	NA
WP_002878619.1\|1382650_1383487_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_002878620.1\|1383616_1385512_-	S9 family peptidase	NA	NA	NA	NA
WP_052001647.1\|1385661_1386573_+	alpha/beta hydrolase	L7RDF8	Acanthamoeba_polyphaga_moumouvirus	1.4e-14	25.2
WP_052001649.1\|1386629_1386980_-	hypothetical protein	NA	NA	NA	NA
WP_080638357.1\|1387124_1387409_-	GGDEF domain-containing protein	NA	NA	NA	NA
WP_002878625.1\|1387469_1387796_-	heavy metal-binding domain-containing protein	NA	NA	NA	NA
WP_072557729.1\|1388029_1389058_+\|transposase	IS30 family transposase	H7BUM7	unidentified_phage	1.3e-48	34.3
WP_002880154.1\|1389191_1390637_+	6-phospho-beta-glucosidase	A0A0B5JD41	Pandoravirus	8.0e-33	26.1
WP_002880156.1\|1390879_1392016_-	sigma-70 family RNA polymerase sigma factor	A0A2I7SAT0	Vibrio_phage	1.2e-36	34.2
WP_002880157.1\|1392051_1393173_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	5.8e-39	37.4
WP_002880158.1\|1393214_1394333_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	4.1e-37	37.6
1394156:1394173	attR	NA	NA	NA	NA
WP_002880159.1\|1394304_1396143_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.1e-58	35.5
WP_002880160.1\|1396174_1398241_-\|tRNA	glycine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_002880161.1\|1398233_1399145_-\|tRNA	glycine--tRNA ligase subunit alpha	NA	NA	NA	NA
WP_002880162.1\|1399408_1400158_-	DNA repair protein RecO	NA	NA	NA	NA
WP_002880163.1\|1400157_1401063_-	GTPase Era	NA	NA	NA	NA
WP_002880164.1\|1401046_1401466_-	cytidine deaminase	NA	NA	NA	NA
WP_002880169.1\|1401467_1401992_-	rRNA maturation RNase YbeY	NA	NA	NA	NA
WP_002880170.1\|1401991_1402939_-	PhoH family protein	H6X2N1	Pseudomonas_phage	3.4e-48	47.9
WP_002880182.1\|1403092_1403269_-	30S ribosomal protein S21	NA	NA	NA	NA
WP_002880184.1\|1403437_1404295_+	kinase/pyrophosphorylase	NA	NA	NA	NA
WP_002880185.1\|1404354_1404624_-	hypothetical protein	NA	NA	NA	NA
WP_002880186.1\|1404690_1405575_-	YitT family protein	M1Q1P6	Streptococcus_phage	4.4e-18	25.9
WP_002880187.1\|1406745_1407930_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_002880188.1\|1408112_1409423_-	diaminopimelate decarboxylase	NA	NA	NA	NA
WP_002880189.1\|1409780_1410515_-	hypothetical protein	NA	NA	NA	NA
WP_002880190.1\|1410664_1410829_-	hypothetical protein	NA	NA	NA	NA
WP_072557730.1\|1410846_1411032_-	hypothetical protein	NA	NA	NA	NA
WP_002880191.1\|1411414_1412311_-	aldose 1-epimerase family protein	NA	NA	NA	NA
WP_002880193.1\|1412396_1413791_-\|protease	ATP-dependent protease ATPase subunit HslU	A0A1B2IB03	Erwinia_phage	8.5e-32	26.0
WP_002880194.1\|1413793_1414327_-\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_002880195.1\|1414435_1415323_-	tyrosine recombinase XerC	S5W9T9	Leptospira_phage	6.4e-25	30.5
WP_002880196.1\|1415322_1416642_-\|tRNA	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	NA	NA	NA	NA
WP_002880197.1\|1416773_1418948_-	type I DNA topoisomerase	E3T4K4	Cafeteria_roenbergensis_virus	1.2e-93	35.8
WP_002880198.1\|1419074_1419914_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	4.1e-29	37.6
WP_002880199.1\|1420011_1420782_-	ribonuclease HII	G9E3X7	Emiliania_huxleyi_virus	2.5e-25	37.2
WP_002880200.1\|1420771_1421629_-	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_002880201.1\|1421703_1421934_-	YozE family protein	NA	NA	NA	NA
WP_002880203.1\|1421937_1422783_-	DegV family protein	A0A0N9SI50	Staphylococcus_phage	1.0e-19	45.0
WP_002880205.1\|1422918_1423581_+	hemolysin III family protein	NA	NA	NA	NA
WP_002880206.1\|1423606_1424797_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	4.0e-46	33.8
WP_002880207.1\|1424869_1425769_+	YitT family protein	M1Q1P6	Streptococcus_phage	1.3e-52	40.5
WP_002880208.1\|1425803_1426049_-	hypothetical protein	NA	NA	NA	NA
WP_035176878.1\|1426122_1426419_-	EAL domain-containing protein	NA	NA	NA	NA
WP_072557731.1\|1426929_1428480_-\|transposase	transposase	NA	NA	NA	NA
WP_072557732.1\|1428451_1429111_-\|transposase	IS607 family transposase	A0A7Q0	Microcystis_virus	1.1e-45	48.2

DBSCAN-SWA_7

1571595 : 1580152

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002879296.1\|1571595_1572177_-	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	4.2e-25	34.8
WP_002879295.1\|1572185_1573220_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	4.8e-64	41.3
WP_002879294.1\|1573222_1574701_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.1e-52	33.2
WP_002879293.1\|1574676_1576899_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	3.8e-143	39.8
WP_002879292.1\|1576898_1577573_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_002879291.1\|1577572_1577821_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_002879290.1\|1577825_1578548_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.8e-37	36.8
WP_002879289.1\|1578856_1580152_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	4.1e-20	32.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP018218

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection