CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP018216	Lactobacillus delbrueckii subsp. delbrueckii strain KCTC 13731, complete genome	2 crisprs	cas14j,Cas14u_CAS-V,cas3,DEDDh,cas9,cas1,cas2,csn2,DinG,csa3,c2c9_V-U4,WYL	0	9	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018216_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018216_1

801361-802320

TypeII

Consensus_repeat	Method
TGTCTGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCTGG	PILER-CR
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CRISPRCasFinder
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CRT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	PILER-CR

14 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_CP018216_1

>merge|NZ_CP018216|1|801361-802320|PILER-CR,CRISPRCasFinder,CRT,PILER-CR
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCACTCTGCTTGACCAAGTCTTGCATTGTCTGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCTTGGCTGAGTTTGAGGCCTTGGAAGTGTCTGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCTGGAAGCTCAAAAAGCTGGTACTGGTTTACGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCCACTTACGCTACTGTTTTACCAACTAAGAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCCACTTACGCTACTGTTTTACCAACTAAGAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCAAGCACACGGCTGAGGAGATTAGCACGACCGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCCTCCTACAGTGCTTTAGCCGCCTGGCGACGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCGTACTCTTCCTGGATCTTCTCCTGGTCCAGGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCGTTGTAGCCCGTCTGCCCAAAGATCGTGTGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCACGTCAAAAGTTTACTTAGAGTTTTGAAGGGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCAGGAGCGGAAGCTCTTTGGCTAATTGATGAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCGCTACCGCATGAAGCGGTCTGTAAACGCCTGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCAAGGAGTTTTTTCAATGAGCCTGGCAATCCGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCACAGATTGAGTTCACGATTGCTGGGGATCCGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC

>NZ_CP018216|1|1|801361-801531|PILER-CR
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCACTCTGCTTGA	CCAAGTCTTGCATTGTCTGTTTTAG
AAGGTTGTCTATTCAATAAGGTTTAACCCTTGGCTGAGTTTGAGGCCT	TGGAAGTGTCTGTTTTAG
AAGGTTGTCTATTCAATAAGGTTTAACCCTGGAAGCTCAAAAAGCTGGTACTGGTTTACGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCCACTTACGCTACTGTTTTACCAACTAAGAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCCACTTACGCTACTGTTTTACCAACTAAGAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCAAGCACACGGCTGAGGAGATTAGCACGACCGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CCTCCTACAGTGCTTTAGCCGCCTGGCGAC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTACTCTTCCTGGATCTTCTCCTGGTCCAG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CGTTGTAGCCCGTCTGCCCAAAGATCGTGT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACGTCAAAAGTTTACTTAGAGTTTTGAAGG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AGGAGCGGAAGCTCTTTGGCTAATTGATGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GCTACCGCATGAAGCGGTCTGTAAACGCCT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AAGGAGTTTTTTCAATGAGCCTGGCAATCC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACAGATTGAGTTCACGATTGCTGGGGATCC


>NZ_CP018216|1|1|801361-802320|CRISPRCasFinder
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CACTCTGCTTGACCAAGTCTTGCATTGTCT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TTGGCTGAGTTTGAGGCCTTGGAAGTGTCT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TGGAAGCTCAAAAAGCTGGTACTGGTTTAC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CCACTTACGCTACTGTTTTACCAACTAAGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CCACTTACGCTACTGTTTTACCAACTAAGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AAGCACACGGCTGAGGAGATTAGCACGACC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CCTCCTACAGTGCTTTAGCCGCCTGGCGAC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTACTCTTCCTGGATCTTCTCCTGGTCCAG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CGTTGTAGCCCGTCTGCCCAAAGATCGTGT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACGTCAAAAGTTTACTTAGAGTTTTGAAGG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AGGAGCGGAAGCTCTTTGGCTAATTGATGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GCTACCGCATGAAGCGGTCTGTAAACGCCT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AAGGAGTTTTTTCAATGAGCCTGGCAATCC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACAGATTGAGTTCACGATTGCTGGGGATCC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC

>NZ_CP018216|1|1|801361-802320|CRT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CACTCTGCTTGACCAAGTCTTGCATTGTCT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TTGGCTGAGTTTGAGGCCTTGGAAGTGTCT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	TGGAAGCTCAAAAAGCTGGTACTGGTTTAC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CCACTTACGCTACTGTTTTACCAACTAAGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CCACTTACGCTACTGTTTTACCAACTAAGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AAGCACACGGCTGAGGAGATTAGCACGACC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CCTCCTACAGTGCTTTAGCCGCCTGGCGAC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTACTCTTCCTGGATCTTCTCCTGGTCCAG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CGTTGTAGCCCGTCTGCCCAAAGATCGTGT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACGTCAAAAGTTTACTTAGAGTTTTGAAGG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AGGAGCGGAAGCTCTTTGGCTAATTGATGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GCTACCGCATGAAGCGGTCTGTAAACGCCT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AAGGAGTTTTTTCAATGAGCCTGGCAATCC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACAGATTGAGTTCACGATTGCTGGGGATCC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC

>NZ_CP018216|1|2|801757-802320|PILER-CR
	CCAAGTCTTGCATTGTCTGTTTTAG
AAGGTTGTCTATTCAATAAGGTTTAACCCTTGGCTGAGTTTGAGGCCT	TGGAAGTGTCTGTTTTAG
AAGGTTGTCTATTCAATAAGGTTTAACCCTGGAAGCTCAAAAAGCTGGTACTGGTTTACGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCCACTTACGCTACTGTTTTACCAACTAAGAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCCCACTTACGCTACTGTTTTACCAACTAAGAGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCCAAGCACACGGCTGAGGAGATTAGCACGACCGTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CCTCCTACAGTGCTTTAGCCGCCTGGCGAC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GTACTCTTCCTGGATCTTCTCCTGGTCCAG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	CGTTGTAGCCCGTCTGCCCAAAGATCGTGT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACGTCAAAAGTTTACTTAGAGTTTTGAAGG
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AGGAGCGGAAGCTCTTTGGCTAATTGATGA
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	GCTACCGCATGAAGCGGTCTGTAAACGCCT
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	AAGGAGTTTTTTCAATGAGCCTGGCAATCC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC	ACAGATTGAGTTCACGATTGCTGGGGATCC
GTTTTAGAAGGTTGTCTATTCAATAAGGTTTAACCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018216.1\|WP_072547248.1\|808326_809271_+\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|234786
NZ_CP018216.1\|WP_072547246.1\|802681_803782_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_CP018216.1\|WP_072547247.1\|806342_807701_+\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NZ_CP018216.1\|WP_035162685.1\|800358_800664_+\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
NZ_CP018216.1\|WP_002877487.1\|807757_808264_-\|aminoacyl-tRNA-deacylase	unknown	unknown	gnl\|CDD\|237976
NZ_CP018216.1\|WP_072547241.1\|792899_793568_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP018216.1\|WP_003619893.1\|805013_806177_+\|hydroxymethylglutaryl-CoA-synthase	unknown	unknown	gnl\|CDD\|213655
NZ_CP018216.1\|WP_003613864.1\|811701_812139_+\|D-tyrosyl-tRNA(Tyr)-deacylase	unknown	unknown	gnl\|CDD\|235383
NZ_CP018216.1\|WP_072547242.1\|793570_794830_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP018216.1\|WP_081369535.1\|791168_791978_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|236111
NZ_CP018216.1\|WP_035162655.1\|803783_805010_+\|hydroxymethylglutaryl-CoA-reductase,-degradative	unknown	unknown	gnl\|CDD\|153082
NZ_CP018216.1\|WP_072547249.1\|809411_811673_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|223394
NZ_CP018216.1\|WP_072547245.1\|800660_801329_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
NZ_CP018216.1\|WP_072547250.1\|812418_813705_+\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|273080
NZ_CP018216.1\|WP_072547237.1\|789609_789834_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NZ_CP018216.1\|WP_072547240.1\|792288_792897_+\|GTP-pyrophosphokinase	unknown	unknown	gnl\|CDD\|225232
NZ_CP018216.1\|WP_072547243.1\|794989_799252_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	mkCas0193_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|374653
NZ_CP018216.1\|WP_072547251.1\|813720_815565_+\|aspartate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234775
NZ_CP018216.1\|WP_072547244.1\|799469_800381_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NZ_CP018216.1\|WP_072547238.1\|790286_791141_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|226484

Protein	Function_ID	Function_description	E-value
NZ_CP018216.1\|WP_072547248.1\|808326_809271_+\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|234786	PRK00517, prmA, 50S ribosomal protein L11 methyltransferase.	4.39875e-92
NZ_CP018216.1\|WP_072547246.1\|802681_803782_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	1.54771e-161
NZ_CP018216.1\|WP_072547247.1\|806342_807701_+\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	4.79877e-64
NZ_CP018216.1\|WP_035162685.1\|800358_800664_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	3.0201e-28
NZ_CP018216.1\|WP_002877487.1\|807757_808264_-\|aminoacyl-tRNA-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	1.17301e-65
NZ_CP018216.1\|WP_072547241.1\|792899_793568_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.60561e-66
NZ_CP018216.1\|WP_003619893.1\|805013_806177_+\|hydroxymethylglutaryl-CoA-synthase	gnl\|CDD\|213655	TIGR01835, 3-hydroxy-3-methylglutaryl_CoA_synthase, 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade. This clade of hydroxymethylglutaryl-CoA (HMG-CoA) synthases is found in a limited spectrum of mostly gram-positive bacteria which make isopentenyl pyrophosphate (IPP) via the mevalonate pathway. This pathway is found primarily in eukaryotes and archaea, but the bacterial homologs are distinct, having aparrently diverged after being laterally transferred from an early eukaryote. HMG-CoA synthase is the first step in the pathway and joins acetyl-CoA with acetoacetyl-CoA with the release of one molecule of CoA. The Borellia sequence may have resulted from a separate lateral transfer event.	9.16099e-131
NZ_CP018216.1\|WP_003613864.1\|811701_812139_+\|D-tyrosyl-tRNA(Tyr)-deacylase	gnl\|CDD\|235383	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional.	5.77324e-87
NZ_CP018216.1\|WP_072547242.1\|793570_794830_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.3086e-28
NZ_CP018216.1\|WP_081369535.1\|791168_791978_+\|FAD-binding-protein	gnl\|CDD\|236111	PRK07843, PRK07843, 3-oxosteroid 1-dehydrogenase.	1.1147e-21
NZ_CP018216.1\|WP_035162655.1\|803783_805010_+\|hydroxymethylglutaryl-CoA-reductase,-degradative	gnl\|CDD\|153082	cd00644, HMG-CoA_reductase_classII, Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR). Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR), class II, prokaryotic enzyme is a homodimer. Class II enzymes are found primarily in prokaryotes and Archaeoglobus fulgidus and are soluble as they lack the membrane region. Enzymes catalyze the synthesis of coenzyme A and mevalonate in isoprenoid synthesis. Bacteria, such as Pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3-hydroxy-3-methylglutaryl-CoA. Human and bacterial HMGR differ in their active site architecture.	0
NZ_CP018216.1\|WP_072547249.1\|809411_811673_+\|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NZ_CP018216.1\|WP_072547245.1\|800660_801329_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	1.4797e-68
NZ_CP018216.1\|WP_072547250.1\|812418_813705_+\|histidine--tRNA-ligase	gnl\|CDD\|273080	TIGR00442, hisS, histidyl-tRNA synthetase. This model finds a histidyl-tRNA synthetase in every completed genome. Apparent second copies from Bacillus subtilis, Synechocystis sp., and Aquifex aeolicus are slightly shorter, more closely related to each other than to other hisS proteins, and actually serve as regulatory subunits for an enzyme of histidine biosynthesis. They were excluded from the seed alignment and score much lower than do single copy histidyl-tRNA synthetases of other genomes not included in the seed alignment. These putative second copies of HisS score below the trusted cutoff. The regulatory protein kinase GCN2 of Saccharomyces cerevisiae (YDR283c), and related proteins from other species designated eIF-2 alpha kinase, have a domain closely related to histidyl-tRNA synthetase that may serve to detect and respond to uncharged tRNA(his), an indicator of amino acid starvation; these regulatory proteins are not orthologous and so score below the noise cutoff. [Protein synthesis, tRNA aminoacylation].	0
NZ_CP018216.1\|WP_072547237.1\|789609_789834_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	0.00121957
NZ_CP018216.1\|WP_072547240.1\|792288_792897_+\|GTP-pyrophosphokinase	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	6.12372e-65
NZ_CP018216.1\|WP_072547243.1\|794989_799252_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|374653	pfam16592, Cas9_REC, REC lobe of CRISPR-associated endonuclease Cas9. The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defense against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.	1.48247e-123
NZ_CP018216.1\|WP_072547251.1\|813720_815565_+\|aspartate--tRNA-ligase	gnl\|CDD\|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NZ_CP018216.1\|WP_072547244.1\|799469_800381_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	2.30926e-94
NZ_CP018216.1\|WP_072547238.1\|790286_791141_+\|FAD-binding-protein	gnl\|CDD\|226484	COG3976, COG3976, Uncharacterized protein conserved in bacteria [Function unknown].	3.8286e-10

>NZ_CP018216.1|WP_072547245.1|800660_801329_+|type-II-A-CRISPR-associated-protein-Csn2
MIITYKAHKSFEIENGKVNVIATSSPIAYCNLIEGMQEKNELLCAVSEDYDAIPLSKAVDWLGDPLISESLLQKYMTKLTSYVVDELSADGRNRIITFYRDLLSAVQDELLMEDLPLEISFDTDLKKLFKFGGLHFNKTLTRDPYGIIETVLRIHDRLDLKSTVVFSNVAHYLDVEQFNEISKLCLELKKSIIFIDFCSHKDQVVYGDAKFSYIDEDLVDWY
>NZ_CP018216.1|WP_035162685.1|800358_800664_+|CRISPR-associated-endonuclease-Cas2
MRLMIMFDLPVDTAVDRKQYRQFRKNLINEGFVMIQYSVYVRVCASKKAAELLEKRIRGYVPEYGVIQSLMLTEKQYNDMHFLLGEPVKDIRNTSDRTVIL
>NZ_CP018216.1|WP_072547244.1|799469_800381_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRNVIITQHSKLSYSSNMMVVHTKDGVSQIPVSDINMLVVLTTQAVITSALIAELAKKQTKVIFVDEKQEPICETENYYSTNCHPEKLIKQFNWDEDRKQILWTKIVAAKIQNQMNVLRIYGLPTDEIEKDFLELELNDASNREATTARKYFTELFGKDFKRREGSNALNAALNYGYSILLSAVNRKITMDGNRTYMGVHHSSEHNPFNLGSDLMEPFRPFVDYWLYDHKNIKEFTSDIKYGLVELLSLRIIYNGDRMILGNAINQYVHDCLRYLDGNLFEMDIELGVDYEVPNDAIDDNV
>NZ_CP018216.1|WP_072547243.1|794989_799252_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MAKPKDYTIGLDIGTNSVGWVVTDDQNNILRIKGKKAIGARLFTEGKVAAERRSFRTTRRRLSRRRWRIKLLEELFDEEIAKVDPSFFARLHESWISPKDKRKRYSAIVFPSPEEDKKFHESYPTIYHLRDKLMKDDQKHDIREIYIAVHQMIKARGNFLHDESVETYRSGMSSLGGRSERTILSVQTLEELNDLFAENEGMEEVELNVASAEQINDILTGDHLNADSQKEISNLLLPSSFPSFDDKAKEKQVKKLINNVATNISKAWLGYKADFSTILNLAKVDKDQKKIFAFALQGGDEEDKVQELESLLEQSQTDIVDRLIEIRHAIVLSEIVPVGMTLSEAMIDKYDQHKEDLITLKAVIRNTKDKKKAAKLQAIYDLYVNNRHADLAKAMKLTGIKKRSELLDPEELKKAISSLLDDSPKAVEIKQRLEEKTFLPLQRSNNNGVIPNQLHQVELDEIIKKQSKYYPFLAEKNPDESEEAQKKAPTKLDALLTFRVPYYVGPMITKEEQEAQDGHSFAWMVRRDPQDHEAITPWNFEKKVDKMASATQFIKRMTTKDTYLLGEDVLPASSLKYQLFTVLNELNNLRVNGKKLTSDEKEQVIEGLFKKQKTVKADKFVKYWQAKHISADIKVKGLSDPSKFNSTMSTYIDFKKIFGDQLNDANRQNDFEKIIEYSTIFEDRKILEDKLRADFAWLSEEQIKQLCRLRLQGWGRLSDKLLTRLTDADGQNVLERLWNSNDNFVQIVSDPNIKAKIEQENQKLLRDGQSDDAVESILDDAYTSPQNKKAIRQVMRVVRDIVKACDGNVPAKFAIEFARSQEDDPKRTTARVNQMQKIYDQISDEVVSQGVKEQLSGMKSLKDRYYLYFMQGGRDAYTGAKLNIDRLSDYDIDHIMPQSFVKDDSLDNRVLVARAVNNQKSDKVPALLFGNKVVADLGITVREMWDKWQKLGMISKRKLSNLLTDPNALTEYRAQGFIRRQLVETSQVIKLTATILQSEFPDSKIIEVPAKYNSIVRKQFDLYKSREVNDFHHAIDAYLSTIVGNYLYQVYPNLRRMFVYGEFKKFSSNAEESAHDVARRVKSMNFLDDLLRGTHGDNIYCRSTDEIVFNRNDIISKLKQAYSFKQMLVTQEVFTKKSALFNQTVYPSPKRDGSKRSGLIPRKRGMDPEIYGGYAHNQDSYFVLAKIEKVKGYTLQIVGVPIRSLEIINKAEDFSTALLDIIKSKVMYNEKTGQPKRGIKNVEILVNKLPYRQPILEKDVSYMLGSSAYKYNVKQITLSQQSMKYILDYIDDPNFTKHEMAMIDEQNERECLLSVYDEILEKVDKYLPLFDGNKFREKLHSARKEFVSLSVDDEASAIEKILRGLHANSEMPSLENLKIKPALGFFQMKNGITLSNDAVLLYQSPTGLFERRVKVSDLLK
>NZ_CP018216.1|WP_072547242.1|793570_794830_+|HAMP-domain-containing-histidine-kinase
MIKKIRRRFIWLATLSLFLVMFFSFSSLIGISLFESSHEADQVLSIIVKNNGRLDEAQAKRRLGDQYNKEGIFKYRYFTANINTKKQTLTVIDADHIIGYSINSVSSRKKQISMRLSAGQLKGTIQSNGVRFRYLAKKISANKYYICFIDLSPLMQSAFLLVRYALIFTFSGILFFVIIMALLADKAIQPIKDAYDKQRRFITNAGHELKTPLAVISANAEMEELLGNDDEWNESTKEQVVRMTGLINQLITLTRMSEPEELVLSKVNFSEITKESADSFKSVLSKDNKKYVVSIDPDLYINAEQRSLLELVNILIDNAQKYCDPEGEVMVVLAKSRLNQNAVLTVTNSYKNGAGIDTNRFFERFYREDESHHYDQKQKNGFGIGLSMAQDLVAAFGGKINASWSDGVMNFTVTFKRVH
>NZ_CP018216.1|WP_072547241.1|792899_793568_+|response-regulator-transcription-factor
MKILLAEDEAQLNRVLTVAMQKSGYDVDSVFNGQEAVDAVKKHPYDVIIMDIMMPVKNGLDVVKEIRATGDKTYIMMLTAKSEIDDKVTGLDVGADDYLTKPFSLKELLARLRSKERRSEDYNSTQELNYDNLKLDLNSQELSSNNSIRLSKQETGLMRYFLLNPGKAISTEELFNHVWKNEDESEDVVWVYVSFLRSKLASIGANVQISGEKGGEFCLERA
>NZ_CP018216.1|WP_072547240.1|792288_792897_+|GTP-pyrophosphokinase
MSIYGKYADYLPQILDSVLQQIQGIGQEYSAKHGQKLYEHLESRVKGEESMTQKCERKGLPLTPESALIENRDAIGLRIVCNFIDDIYTCIDLLKKQDNFKIINEKDYITDAKPNGYRSYHLIIEVVTPFEDVHGNKPGTYYVEIQLRTIAMDTWASLEHEMKYKHDIKNPERISKELKRVADELASCDVSMQTIRQLIKEG
>NZ_CP018216.1|WP_081369535.1|791168_791978_+|FAD-binding-protein
MIASGGYLGNKELLLKYLGTTHVNVAARGKSLCTGDGLAIAQKAGAILDKTFGYCGCEYGGTNPKASRPATQYKYDQNLAFKFGIYSNLLVDNQGKRFMNKGFLCDYPMSYGEEPTLRHSPYYAIVDQEYVDKMWDEGLYEYLTKRGANHDNWFIGSYYKQRGALKSLDSDLEEGIHEGWIVKADTLEELAKKTGFDHLTGTVASYNSYCEKGEDEQFGANPWYLSSVKQGPFYAIECEVSAWSTFGGVKTDDECRALAEDDQVIPGML
>NZ_CP018216.1|WP_072547238.1|790286_791141_+|FAD-binding-protein
MYKKGDYEVEAEGHHSTVKLRVSFDKEKLTKIEVLEENETQAFVDDLKDRFIPEVVANQSLNADAISGATKLTKAVTSSVEEAITEAGGDPKTFTEAAHVTETKLPDDDVIADVVVIGSGASGFMSAITAAKAGSKVVVLEKAGNLAAVNGVKVSGPFAVNTPVLRERGTTLTVNEVFQHVMNYTHWEPNSALIRNYLEHSSEAVENLLEIGYQFKEANFRFKTPFVDEKGGFHLILTDVDKRVRLWTEAYEKYCVDAFFNTAAKEVLKENGKIAGVAGQRKDG
>NZ_CP018216.1|WP_072547237.1|789609_789834_-|helix-turn-helix-transcriptional-regulator
MNALQKYFDQNGVTRYQVAKQTGIANTTLANAVKETKPLSGQTVKVITAVAQALGKTPGQVLDDLIELDEDNSK
>NZ_CP018216.1|WP_072547246.1|802681_803782_+|thiolase-family-protein
MQDIYIVAAKRTPFGRYHKQLADFSAIDLGQIALRGALKEAGLDAEALDALFMGNVLSAGLGQNMARQIALNAGMRQDSVAVSINEVCGSSLKAARLAEAQMLIGDLGLVAVGGSESMTNAPKEIMFSDGLVDSFSGKSMGITAENVAKRNHISRQDADAFSLSSHQKAVKAQAEGLFADEIIQIEDLKQDENVRPDTSLEALAGLKTSFLEDGTVTAGNASPISDGASMIILATSEKVAEYQLTPLAKLGAYAEVGYDPEFMGYGPYYAIRKLLNETGRQVADYDFFEINEAFAATTLAVARDLEIPLAKVNKQGGAIALGHPLGASGTRLLATAARQLQRGGQRAIASLCIGGGLAIAFEIEKA
>NZ_CP018216.1|WP_035162655.1|803783_805010_+|hydroxymethylglutaryl-CoA-reductase,-degradative
MKFYQLPPEERRQFLQEDGVALEDIPAADLARLDEMSENVVGEVKFPLSCLTSALVNGKNWRIPMTTEEASVVAAANHGMSVFAKAGGVKATSQRDGIYGQIVLEVTEAFSLADFKNKFPAYIKEANKEFASLIRHGGGLKDLTARQEADLVYLLALVDPAEAMGANKTNAILEFLAQKMLAFPGVEAKLFAILSNYPSQLTTAKVAIPVSLLSKKGDLAEGREVAKKMALLAKIGSSDPYRAVTNNKGIMNGVDAVMLATGNDYRAVEAACHAYAAKSGQYRSLSSWKLEGEKLLGQVTLPLALGVVGGSISSRPDIRQSYAILGKIKAAELAELTASVALANNFAALNAISTKGIQAGHMRLQSRNVVQTLPAAAEEKEAVYQMMISQGKYGETAAKNFLKELRGQ
>NZ_CP018216.1|WP_003619893.1|805013_806177_+|hydroxymethylglutaryl-CoA-synthase
MDIGIDQIGFYTPNKFVDMVDLANARNQDPNKFLIGIGQDRMAVADKTQDAVSMGINATAEYLDQVDLEQLGLLIFATESGIDQSKSASLFVKEALNLPARIRTFEIKEACFALTASLQVARDYVRAHPHHSAMIIGSDIARYGLATAGEVTQGAGAISMLIKENPAIIALEDGHTSHSENINDFWRPNNLATAVVDGHYSRDVYLDFFKSTFKPFLAEKQLQVSDFAGICYHLPYTKMGYKAHKIAIEGQDDETVKRLSDNFQLSAKYSRQVGNIYTASLYMSVLSLLENGDLEAGDRIGFFSYGSGAMAEFFSGKVVAGYQKRLRPALHARMLKERIRLGVGQYEDIFTEGLEALPENVEFTSDANHGTWYLAGQEGYVRQYKQK
>NZ_CP018216.1|WP_072547247.1|806342_807701_+|threonine/serine-exporter-family-protein
MKTESTEQEYHHHLSHHHHMRVQWEEFFQSDDETKIKEATLIEKGSIISRVGMMMLSCGTGAWRVRDAMDTLARTLDLTCSTDIGLISIVCTYFDVDNQSYSQSLALPTTGVNMAKLNELEKFVRQFEAAGGDFEIKTIRRRLGEIEHMKGRYPLWGSSLAAALACGGFIFLLGGGVPEIICSFIGAGLGQFARGSLAKRRITIAATTAVAVAAACLSYYLAFMLGHLLFNVDMIHMRGYIGAMLFVIPGFPFITSGLDISKLDMRSGLERMAYAIFIILIATGTGWVMATALQIKPGDLPALHLSKAILTACRLVASFCGVFGFSLMFNSHRRMAAAAGLVGAIANTMRLSLVDFAHFPAPLAAFLAALLAGLLAGYVREKVGYPRIALTVPSIVIMVPGLYMYRGIFLLVLTNVGAGATWMTEALMLVMSLPAGLLTARILTDKKWRRVD
>NZ_CP018216.1|WP_002877487.1|807757_808264_-|aminoacyl-tRNA-deacylase
MSKKKKNKDKLDKTLVEKILDQHKIAYEQHISEISEDHGVAQVGTGKPVLDGHPVYKTLAVNGNKTGPIVGVVPLSGHLDLKKIAKASGNKKCEMIPLKQLEKTTGYVHGANTPIGIYHSKKFPIFLDKSVLNEDGIWVSSGEVGRSVMVNPLDLQKLVKATVADLQE
>NZ_CP018216.1|WP_072547248.1|808326_809271_+|50S-ribosomal-protein-L11-methyltransferase
MKLLEIKIESSYDVEDALAYFATEDLKALGTEARRRSDFEQAGWLHDSMVVDMDDIPNLPDELEFIAYFDEETDPEETVKCFKDKLAELAGYGLKTAPGEISVDYVVDQDWNTVWQKYYHVINLSRHLAIVPEWEDYQPAFKDQEIIRLDPGLAFGTGNHQTTQLAMLGIERAMVKPLTVADVGTGSGILAIAAHKLGAKSVLATDISDESMTAAKENAALNGIHDIALQKTSLLAGVDGKFDLIVANILAEILLDLIPQLDSHLNEDGQVIFSGIDYLQLPKIEQALAENGFQIDLKMRAGRWIGLAISRKHD
>NZ_CP018216.1|WP_072547249.1|809411_811673_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MSKYIEMTHEQVMAACKKYMTADQLAFVESAYQFAARAHEGQTRASGQPYIVHPTQVAGTLANLGLDPDTVAAGFLHDTVEDTSVTNDDIKEKFGADVAFIVDGVTKLNKYEYKSHKEFLAENHRKMLIAMAKDLRVILVKLADRLHNMHTLEHLRPDKQRRIAAETLDIYAPLADRLGIGTIKWELEDMSFHYMNPEEYYKIVSMMNAKRSEREDYIKDAIDYLRGTLDSLGIKYDISGRPKHIYSIYKKMVNKHKDFNEIYDLLAVRVIVPTVKDCYAVLGAVHTKWKPMPGRFKDYIAMPKANGYQSLHTTIIGPGGKPLEIQIRTEEMHKVAEYGVAAHWAYKRGNFQGVDEKDGGALDIGREILELQKDSNNADEFMEAIHSDIFADKVYVFTPKGEVYELPKGSVTLDFAYAIHTQVGDHGIGAKVNDKLVPLDYKLKNGDVVDILTQSNARPSRDWAEMVKTSRAKNKIRRYFRDVDREESLARGKSELVDLLKENGLSAKDFLDKSHIDEVLDHFSFKTDEDMYAAIGFGNMSAVSIYNRLTADLRRQQEEEKQKRFEAQIMSAGQQAAASSVVKKPASQKDDAKSKTKGKKPDSLVRVQGLEDLDMHFAKCCNPVPGDRIVGYVTKGRGVTVHRADCRNVVSADPAAQGRMIDVEWNNIDEGKQASFNANFELFGYNRQKLLGDVINRLNALTKNITNVSASVNEENIAHFYITVEVRNAAQLNDIMAKLRDIPDVYDTKRTDN
>NZ_CP018216.1|WP_003613864.1|811701_812139_+|D-tyrosyl-tRNA(Tyr)-deacylase
MRVVIQRVNHAAVRIDGETVGQIQKGLLLLVGLAEGDGEEQVVKAADKIAKMRIFEDEAGKTNLGIKDVGGQILSVSQFTLLADTKKGNRPSFVHAMRPPKSSQLWEEFNQELVKRGLTVETGEFGADMKVELENDGPFTIVLDL
>NZ_CP018216.1|WP_072547250.1|812418_813705_+|histidine--tRNA-ligase
MRVQRPKGTVDILPETSGQWEKVEQTARDLFKRANYHEIRTPSFENYELFSRSSGETSDVVEKEMYDFEDKGGRHIALRPEGTAGVVRAYVENKIYGPDYVKPFNVYYIAAMYRYERPQAGRQREFHQIGVESFGSNGYLADVETILLGHDLLAELGVKNYELHINTLGDSEVRQAYHDALVDYFTPVKDQLSEDSQRRLGKNPLRILDSKAEEDQQFLPEAPKIRDYLDEESKENFNKILASLDKLGVKYVIDDDLVRGLDYYTGVIFEFMVDDPTLWASPSTVLGGGRYNHLVEEFSGPETPAVGFGIGEERLMLVLSKQNPEMFEDQGIDFFITNIGEGTDIKAVEVARQLRSLGFSAQYDVDQKKLKAQFRKADRVGARYVVTLGAKELAEGKLTVKRLSDGQQFSLEFTDLEDKADLLFKIEK
>NZ_CP018216.1|WP_072547251.1|813720_815565_+|aspartate--tRNA-ligase
MMQMEKRTDYCGNITSQYLDQDVLLYGWVQRVRNLGQLIFIDLRDREGIVQVVVNHDSGQELMDVASSLGQEYVVEVKGHVNERSSKNPDMKTGDVEVIASEITVLNKAKTPPFEIKDDLVASEQTRLKYRYLDLRRPTLQNALIMRAQIMTATNAYLSGEGFINIETPDLGKSTPEGARDYLVPSRVYPGSFYALPQSPQIFKQLLMGAGFDKYYQIARCFRDEDLRGDRQPEFTQIDLETSFMDEEGVQEVTEGLLAKVMKDVKGIDLQLPLPRITWQESMDKYGCDKPDTRYEMLIHDLGNVFAKSGFKVFASALENGGFVRGIAVKDGAKFYSRKKIEAMQDYIKRYHAKGLAWVKYEDGDFSGPVSRFLSEEEKNGLVQEFSLEGGELLLFIADQWKVCCDSLDYLRRQTAKETGIIPKDTYKYLWVVDWPLFEYDEGDERWIAAHHPFTMPDDKGIELLETDPHKAHARSYDIVLNGYELGGGSIRIHKRDIQEKMFKALGFTKERAYEQFGFLMDALDMGFPPHAGLAIGLDRFAMLLAGKDNIRDVIAFPKNASASEPMMHAPAPVADQQLTDLGIEVAEAAKEGVEKYEASLEAEAAEDVKSHEE

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Crispr_ID: NZ_CP018216_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018216_2

1110718-1110821

Orphan

Consensus_repeat	Method
CCGCTGCCCCCGCACTTGTCACAGGT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP018216_2

>merge|NZ_CP018216|2|1110718-1110821|CRISPRCasFinder
CCGCTGCCCCCGCACTTGTCACAGGTCGTCTGCCGCTGGATTATGCCCAAAACGCTTCTTTGCGTAATGGTCATCATGCCGCTGCCCCCGCACTTGTCGCAGGT

>NZ_CP018216|2|2|1110718-1110821|CRISPRCasFinder
CCGCTGCCCCCGCACTTGTCACAGGT	CGTCTGCCGCTGGATTATGCCCAAAACGCTTCTTTGCGTAATGGTCATCATG
CCGCTGCCCCCGCACTTGTCGCAGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018216.1\|WP_002876681.1\|1102140_1103166_-\|branched-chain-amino-acid-aminotransferase	unknown	unknown	gnl\|CDD\|237363
NZ_CP018216.1\|WP_002876694.1\|1107537_1108239_-\|class-A-sortase	unknown	unknown	gnl\|CDD\|320680
NZ_CP018216.1\|WP_072547433.1\|1096482_1097337_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP018216.1\|WP_072547440.1\|1113305_1113923_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|237631
NZ_CP018216.1\|WP_072547438.1\|1105264_1107541_-\|single-stranded-DNA-specific-exonuclease-RecJ	unknown	unknown	gnl\|CDD\|273193
NZ_CP018216.1\|WP_003613762.1\|1100889_1102023_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP018216.1\|WP_072547437.1\|1104747_1105275_-\|adenine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235028
NZ_CP018216.1\|WP_072547446.1\|1118914_1119241_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP018216.1\|WP_072547441.1\|1113934_1114978_-\|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
NZ_CP018216.1\|WP_072547444.1\|1117530_1118529_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP018216.1\|WP_072547442.1\|1115113_1116055_-\|riboflavin-biosynthesis-protein-RibF	unknown	unknown	gnl\|CDD\|235536
NZ_CP018216.1\|WP_072547436.1\|1104366_1104669_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP018216.1\|WP_072547445.1\|1118729_1118924_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378935
NZ_CP018216.1\|WP_013439791.1\|1108219_1110058_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP018216.1\|WP_003615406.1\|1111401_1113246_-\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NZ_CP018216.1\|WP_072547447.1\|1119391_1119709_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018216.1\|WP_072547448.1\|1119705_1120569_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214926
NZ_CP018216.1\|WP_072547443.1\|1116168_1117311_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP018216.1\|WP_072547435.1\|1099833_1100781_+\|LytR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|181811
NZ_CP018216.1\|WP_072547434.1\|1097514_1099773_+\|HAD-IC-family-P-type-ATPase	unknown	unknown	gnl\|CDD\|319771

Protein	Function_ID	Function_description	E-value
NZ_CP018216.1\|WP_002876681.1\|1102140_1103166_-\|branched-chain-amino-acid-aminotransferase	gnl\|CDD\|237363	PRK13357, PRK13357, branched-chain amino acid aminotransferase; Provisional.	0
NZ_CP018216.1\|WP_002876694.1\|1107537_1108239_-\|class-A-sortase	gnl\|CDD\|320680	cd06165, Sortase_A, Sortase domain found in class A sortases. Class A sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). They perform a housekeeping role in the cell as members of this group are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is cleaved at a conserved cell wall-sorting signal (Class A sortases recognize a canonical LPXTG motif, X can be any amino acid), and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical sortase A protein from Staphylococcus aureus (named Sa-SrtA) cleaves the amide bond between threonine and glycine residues of the canonical LPXTG motif in a wide range of protein substrates with diverse functions that can promote bacterial adhesion, nutrient acquisition, host cell invasion, and immune evasion. Next, it catalyzes a transpeptidation reaction by which the proteins are covalently linked to the peptidoglycan precursor lipid II. SrtA is therefore affects the ability of a pathogen to establish successful infection. SrtA contains an N-terminal hydrophobic segment, a linker region and an extra-cellular C-terminal catalytic domain. The hydrophobic segment functions as both a signal peptide for secretion and a stop-transfer signal for membrane anchoring. The catalytic domain contains the catalytic TLXTC signature sequence where X is usually a valine, isoleucine or a threonine. The gene encoding SrtA is generally not located in the same gene cluster as its substrates while the gene encoding SrtB is usually clustered in the same locus as its substrate.	1.67884e-58
NZ_CP018216.1\|WP_072547433.1\|1096482_1097337_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.07202e-48
NZ_CP018216.1\|WP_072547440.1\|1113305_1113923_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|237631	PRK14162, PRK14162, heat shock protein GrpE; Provisional.	4.0325e-87
NZ_CP018216.1\|WP_072547438.1\|1105264_1107541_-\|single-stranded-DNA-specific-exonuclease-RecJ	gnl\|CDD\|273193	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ. All proteins in this family are 5'-3' single-strand DNA exonucleases. These proteins are used in some aspects of mismatch repair, recombination, and recombinational repair. [DNA metabolism, DNA replication, recombination, and repair].	5.59675e-161
NZ_CP018216.1\|WP_003613762.1\|1100889_1102023_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	1.41037e-43
NZ_CP018216.1\|WP_072547437.1\|1104747_1105275_-\|adenine-phosphoribosyltransferase	gnl\|CDD\|235028	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional.	1.21554e-94
NZ_CP018216.1\|WP_072547446.1\|1118914_1119241_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	0.00241967
NZ_CP018216.1\|WP_072547441.1\|1113934_1114978_-\|heat-inducible-transcriptional-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	1.1809e-124
NZ_CP018216.1\|WP_072547444.1\|1117530_1118529_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.90679e-09
NZ_CP018216.1\|WP_072547442.1\|1115113_1116055_-\|riboflavin-biosynthesis-protein-RibF	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	4.88287e-113
NZ_CP018216.1\|WP_072547436.1\|1104366_1104669_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	5.80442e-13
NZ_CP018216.1\|WP_072547445.1\|1118729_1118924_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	2.46785e-06
NZ_CP018216.1\|WP_013439791.1\|1108219_1110058_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP018216.1\|WP_003615406.1\|1111401_1113246_-\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_CP018216.1\|WP_072547448.1\|1119705_1120569_+\|hypothetical-protein	gnl\|CDD\|214926	smart00942, PriCT_1, Primase C terminal 1 (PriCT-1). This alpha helical domain is found at the C terminal of primases.	1.54665e-10
NZ_CP018216.1\|WP_072547443.1\|1116168_1117311_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	5.06173e-48
NZ_CP018216.1\|WP_072547435.1\|1099833_1100781_+\|LytR-family-transcriptional-regulator	gnl\|CDD\|181811	PRK09379, PRK09379, LytR family transcriptional regulator.	1.10836e-70
NZ_CP018216.1\|WP_072547434.1\|1097514_1099773_+\|HAD-IC-family-P-type-ATPase	gnl\|CDD\|319771	cd02076, P-type_ATPase_H, plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases. This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0

>NZ_CP018216.1|WP_013439791.1|1108219_1110058_-|elongation-factor-4
MDLEKLKDYQKHIRNFSIVAHVDHGKSTIADRILELTDTVSKRQLKNQMLDDMPLERQRGITIKMNSVQVKYHANDGEDYIFHLIDTPGHVDFSYEVSRSLAACEGAVLVVDASQGVQAQTLSNTYLALENDLEILPVLNKIDLPSADPDMAKSEIGDMLGLDASDAVEVSGKTGAGIPELLERIVTDIPAPTGDLTKPLKALIFDSKYDDYRGVVMSVRIEEGTVKPGDEIMIMNTGKKYEVTEVGVSSPHPVKEDILIAGDVGYITANIKSVRETRVGDTITSAENPTAEALPGYRQIPPMVYSGMYPTDNRDYDDLKEALQKLQLNDASLEFEPETSQALGFGFRCGFLGLLHMDVVQERLEQEFDLDLIMTAPSVDYHAIMPTGEVKLIDNPADLPDAGEYKELQEPYVKAEIMVPNDFVGAVMQLCEGKRGEFQTMDYLDKYRVNVIYEMPLAEIIYDFFDQLKSSTKGYASLDYEIIGYKATNLVKIDILLNKEPIDALSFIAHREEARDRAVQMCSLLKKLIPRQNFQVDIQGAIGSKIISRATIKPYRKDVTWKIHTGDPDRRAKLLEKQKRGKKRMKSVGRVEVPQDAFMAVLRMNDDDINGK
>NZ_CP018216.1|WP_002876694.1|1107537_1108239_-|class-A-sortase
MTSTASKNTKDHPVRRIILRLVAVILFLLGLALVFNQQISAFLVKQNQTAALKGLTRDQVVQNQKKKGMYDFKKVKSIDFAQTTRSRVKNTAGAIGAISIPSVKLYLPVMQGLSDAALSKGGGTMRADQKMGKGNYPLAGHYMTDQGALFSPLERVKLGSMVYLTDLKKVYAYKIYYKKVVDPSAVWLVANTKKKIVTLITCADGGVNRWSLRGKLTAVKPASKQNLEMFKLR
>NZ_CP018216.1|WP_072547438.1|1105264_1107541_-|single-stranded-DNA-specific-exonuclease-RecJ
MKWQERTADPLASDLVEEFQLSPLTAKLFSLRGIDNEEKIDYWLHASENDLADPFLMHDMDKAVGRINQALDEGEKITIYGDYDADGITATAIMTEMLTIMGADVHYFIPDRFKDGYGPSLDRYKDIVADGTKLIITVDNGVTGIEEVAYAQSHGVDVIVTDHHTFKEEKPDAYALVHCNYPGQAYPFDDYCGAGVAYTIARAVLEDTASEFLELAMIGTIGDMVKVSGEGHVIVKRGLEMLNESSRPGLEALIRNAGLTPGMIDEEDVGFSIAPRLNACGRLADASLAVRLLLAESPGEAQELADQIEKLNNERKDLTQATMQAAEAQIKSRGYQKDATLTLYDPAWHEGVMGLVANKIVEKYHKPTLMLTKNEAGLVKGSGRSSQGFNLFNALKPFEGKSITQFGGHDFACGLSTTEENLNQLRRDFNQSYKAGEKAPEKVQEYDGTISPLDVDLTSVYDLAQAGPFGTDNPQPVFLLDKPQISNFRPMRKGCSFMVGPVRAVDFDHGLNQTVLPYLQQMLVKLASNTFKGKTNVQFRIVDLHYGQSLYAPSARIVDFRGQENLLGFADKYLLFDEKNLSQAINHFGITKEQISLAKDNEDLSQQVVSVLDVPANEAQLNFVLAKPYRQLYLRFQLDQLPGETLPSRGNFGLVWQYFLAHPGLKPNDYMQAAGQLGMDPDSIMFILRVFFTLDFVKMEEDRLLPKPSPTKKSLDDSAYYRSVKAKYAFANKLRTISSDELIRYASGLANGGLQNVN
>NZ_CP018216.1|WP_072547437.1|1104747_1105275_-|adenine-phosphoribosyltransferase
MSIDFKKYIASVKDFPNEGIIFRDITPILQDGEAFAAATHELAEYAKSRQADVIVGPEARGFLVGTPVAIELGIGFVPARKPHKLPRKVEAAAYDLEYGSNVLEMHKDAIKPGQRVVICDDLMATAGTLHATKELIERLGGKVVGAAFYIELTDLKGREKFPDVDIFSLVQYTGA
>NZ_CP018216.1|WP_072547436.1|1104366_1104669_+|winged-helix-turn-helix-transcriptional-regulator
MTHEELIDQAARLFKVLGSSLRIHILFYLRKHGESPVSAIVGHLGVSQPVISKQLGILKKYDFVQKRKVGTFVYYSINDQDIVQIIDAMTEHLDHLDRLQ
>NZ_CP018216.1|WP_002876681.1|1102140_1103166_-|branched-chain-amino-acid-aminotransferase
MAKKDLDWANIGFGYHQTDKRYVDYFHDGAWEGGKLTDDPNVVLNECAETLQYAQQVFEGMKAYTWKDGSVVVFRPDQNAERMYNSAKRIEMQPYPKDKFVEAIDQVVKGNVDWVPPYGSGATLYLRPYEIGTTPIIGVAPATDYMFRIFATPVGPYYKGGATPVAVQVAQYDRAAPRGTGHVKAALNYAMSLKATVAAHQAGFAENMYLDPATQTYIEETGGSNIIFIDQNNHLVVPKSNSILPSITRRSIVYLAEHYLNLTVEERQVRFDEVPSFKECALVGTAAVLSPVGRIVNGDQVIDLPSGMDKPGKFMEELYNTLTGIQNGEVEAPEGWIHHVM
>NZ_CP018216.1|WP_003613762.1|1100889_1102023_-|AI-2E-family-transporter
MNKFWNHIDQKYFKIALYCLGTVFAGLFILLLAYESTGFWVRVGKILAAIAQPLTYGLVLTYLLLPLTNFFDRKFSKGSSRGAVATASRSAAVALTLLLLLLVILLAATAVFVTFSKQLSHFSLGSLESLYDQLKAQYSSFINEILAYLQKQGWSTSGLVSYMQKGVGRVTGFLSDFFFGVIFAIYFLYDGQRIAAYWKRNLGTLLNKKVIKGIKLFLADADRAFSGYIRGQIIDAFIVGLLVSLAMLIAKVPYGLLIGLVTGLGNLIPYFGPILGYGMVILACTLSQNMTALIVGMIILLLIQAIDGNILNPKLLSSAIHIHPLYVIACVIAGGAMGGFVGMLIAVPIGALLKTEFERLIAYRQKQLEKSKEASEE
>NZ_CP018216.1|WP_072547435.1|1099833_1100781_+|LytR-family-transcriptional-regulator
MRKRIFRIIMSLAILLLVILSGMLAYSYFNVERAVSRSYQKSGLKSAENGSKEEVLKGKKPLVVLLLGTDTGALGRDYKGRTDSIMVLVLNPRTKKSTIVSIERDFQVNFPQYPQYSPSKINAAYTYGGVKLLSQTLDRYFKIPVNTYALINMGGMKSIIDQLGGVDITPLLSFDYEGYSYKKGVTTHMNGDKALEYCRMRYDDPEGDYGRQKRQRQVLTAIIKSGADVQSLLKPAFLNSVSSQVRTDLTFSDLTQMAKSYRASGDQLETDYTHGTGFNQDGVSYQHISLAERQRISDLVRQAAGLKKVQLANGQ
>NZ_CP018216.1|WP_072547434.1|1097514_1099773_+|HAD-IC-family-P-type-ATPase
MKVKGLTQAEADLRLKKDGLNQVPEPEFSFWKEFAGKLWNLSAWILEAALLLECALGKWIQSLFVLLMLLFAAYNGATQKKKSRKVLSSISQQLTPVVAVLRDDRWQKIDSKYLVVGDIVNLQKGDILAANIDLLDGNLTLDESSITGEAKNVHKKAGATAFAGTTVMDGEALGRVSATGTNSRSGQTINLINKSAAPGHLQQLLTKIIYYLCLLDGVLTVILLITAVIRGENILEMLPFLAMMFIASIPVAMPSTFALSNSFEATRLSKEGVLTSDLTGIQDAANLNLLLLDKTGTITENKTAVASFANFSKLSDEEVLALTSLAIDQRNQSVIDLALMDFLQEKKIPVKEAEAFTPFTSSQGYSEGRGEGHDVKLGSVKQFSKIDPAISEQMAAVDLSLGRSVGILLDDRLAGIFITKDKVRADSKAALAELVKRGIKPIMLTGDNQKTAASVAEEVGLTGKVISISDFKEGVKAEDLAGIADVLPEDKLDMVKYFQKAGYIVGMTGDGVNDSPALKQAEVGIAVSNAADVAKKSSKMVLLDEGLSPIVKILDAGHRVYQRMTTWSLTKLARTAELTMLLTFSYLIFGYLPMALNAMVIYTIMNNMVTMMIGTDKTHITYKPENWDMGKLAKIAFSLAGAWTIIGFAFVSALTKAGVNHDQVGTMVYVFLVMSAMMIVLITRTKRFFWQSAPSKPVASVQIADILLTCLLALLGIAMPAIGIKELLTTLAVAFLAAILIDLVYQPVMKNK
>NZ_CP018216.1|WP_072547433.1|1096482_1097337_-|LysR-family-transcriptional-regulator
MNFKQLNYFLVVAEEGQITSAAKWLFVGQPALSYQLKQLEEELGAKLFIRQPYGIELTEAGKKLRDYAGQILTLAKNVQTEITELDRGGRGRVKLGSVSSSIGELPSAKLTAFARQHPGVSFDIYEDNTFGILDKLQGNLLDLAIVRTPYNRVNLNFVDISDEPMTAVTCQDFFPGKGKVRLQALAGQPLVIYRRFEDMFKEAFAEKGLTPNFVVKCDDSRTAIRWSDSGLGIALVPESIAKTYAKGHIYPIDSAKWRTRLQLVWRKDRVVTPLMRQIIALYAK
>NZ_CP018216.1|WP_003615406.1|1111401_1113246_-|molecular-chaperone-DnaK
MSKVIGIDLGTTNSAVAVLEGKEPKIITNPEGARTTPSVVAFKDGEIQVGEVAKRQAITNPNTIVSIKRHMGESDYKVKVGDKAYTPQEISAMILQYIKKFSEDYLGEPVTDAVITVPAYFNDAQRQATKDAGKIAGLNVQRIINEPTASALAYGLDKDEDDETVLVYDLGGGTFDVSVLQLGDGVFQVLSTNGDTHLGGDDFDNKIIDWLVDGFKQENGIDLSKDKMAMQRLKDAAEKAKKDLSGVSSTHISLPFISAGEAGPLHLEADLTRAKFNELTDDLVQRTKIPFDNALRDAGLSVGDIDKVILNGGSTRIPAVQEAVKQWAGKEPDHSINPDEAVALGAAIQGGVISGDVKDIVLLDVTPLSLGIETKGGVFTKLIDRNTTIPTSKSQIFSTAVDNQPAVDIHVLQGERPMAADNKTLGRFELTDIPAAPRGVPQIQVTFDIDKNGIVNVSAKDLGTGKEQKITIQSASGLSDEEIERMKKEAEEHAEEDAKKKEEVDLRNEVDGLIFQTEKTLKEVDGKLADSDIQPVKDALEDLKKAQKDNNLDEMKEKKDALSKVAQDLAVKLYQQNAQNQQGQGGQAGPTDDGSNGANGDTVDGDFTKVDPDK
>NZ_CP018216.1|WP_072547440.1|1113305_1113923_-|nucleotide-exchange-factor-GrpE
MSKEEFPSEKDLPQEDQEKQAKAAEADKAGVKDDKKVKDNKEEAAKPADVELDQLKAEVAALTQKNKDLEDKYLRSQAEIQNAQRRYSKERANLVKYESQRLGKDILSSVDNLERALQVKADDEASRQLKKGIEMTLEGLVRALKDNGIEEIKADGEKFDPTLHQAVQSVPAENDNQKGHVVQVLQKGYVYKDRVLRPAMVVVAQ
>NZ_CP018216.1|WP_072547441.1|1113934_1114978_-|heat-inducible-transcriptional-repressor-HrcA
MLTERQELILKTIIQDFTKTHEPVGSKTVMNQLSIKVSSATIRNEMAVLEEHGLIEKTHSSSGRVPSTEGYRYYLDNLVQPLQLPEEMYNQIGYQFDQQFNQVDEIVKEAAKILSDLTDYTAFAEGPEAKNVSITGFRIVPLAPRQVMAILVTSDGSVKNQLYTLPRHISGDEVEQAVRLINDQLVGKNLSEINKQTFEQLSSSQIVGKNAPEFLELLEAVIKDAASEQMYVDGQLNLLNNTENSDLKAIKSLYELINSSSMAGELIDLSDSPSHYPVYVRLGAELENELLKDFSLVMAEYSVGRYGRGTIALLGPRHMPYSEMIGLMEYFRQELARKLLDYYGRFK
>NZ_CP018216.1|WP_072547442.1|1115113_1116055_-|riboflavin-biosynthesis-protein-RibF
MKVINLSYPFKKELTAGKVVLALGFFDGVHIGHQKLIKEAKIIAVEKDLPLMVLTFDRHPKEVYAGVKDFEYLNTPEEKAYEMSKIGVDYLVILKFTPEFSHLAPQAFVDEIIMGLKADTVVAGFDYSYGPKDVANMENLPAFAKGRFDIKVVPKQIFAGKKIGSTEIRQAVKSGNLRLATELLGHPYLISGKVVHGFRNGHKLGFPTANLELDWPKVLPKIGVYATMTQVGDRWYQSMTSVGYNVTFNDEKKIYIESNIFDFDQDIYGQQITIAWYKYLRGEEKFADMAALSEQLKLDQVASKNYFSSLIEQ
>NZ_CP018216.1|WP_072547443.1|1116168_1117311_-|site-specific-integrase
MNKKDIIKYQTASGKDRYKFIVYAGKDETTGKSIIIRKQGFKTLKEAKQAYLDVQQAILNGDYLPINQKRLTFKGLLELYLPLYAQTVKETSFYQFKRCMESKVLPVLGDVYLDKITPQLCQKAVNQWARERPKSFDRVIVWTSKVLKYAFKVGLIDSNPFDRVIVPKKPAKKKKENFYTKDELETFLNGARDAGMMKYTLFRLLAFSGMRIGELIALEWSDVDFASQSVSVNKTLTLDKYGQATVGSPKTTNSNRAVLLDDVTMTILRQWRAEQARRIIYFGKPRNNLVFASEHGGHLSNGTIKGWNKKIAENKGLRAISLHGFRHTHASLCFEAGLTMQDVKERLGHSSISTTMDIYTHVTNNRKEESVQQLAKFMRA
>NZ_CP018216.1|WP_072547444.1|1117530_1118529_-|helix-turn-helix-domain-containing-protein
MNRIKQLRKEKGLTLQQVADGLTARLSKPKFDLQQFSEGGSSKQGKKPIAKSTVLRWENEKNSPTAEMWGLLADYFGVSVDYLKGAWSKKEVLELMSSSLLDNYDRVHELALEYCGGEGEEWRFFDEIDIESTENLSFLPGSHEVYKIKKSIAETNIINELRKNYFEGLAFAILHFVYYRGVCRNFHTEEHFKLDKSGPNGELTDENIAFFNYPKIQGYKNIQHFMMNFYRKRNVEERLTFLDTFFHEYDDNSILEDAVVNKIMQEKAPAETMALVLTSVIEAASRNLSFLVGSEERVYNFLASRQQYKDLSNEFDEIQKENDRLKAELASK
>NZ_CP018216.1|WP_072547445.1|1118729_1118924_+|helix-turn-helix-domain-containing-protein
MSQDVLTRKQAMDALNVKDYRTLNKLVEAGLPVIQAGSYVRFSKSDISAFLEKHTKKGGEASCK
>NZ_CP018216.1|WP_072547446.1|1118914_1119241_+|helix-turn-helix-domain-containing-protein
MQITLDSDQEQEIKSYLFNLVKQSFEGMHLEPESRPYLNRNQIAAFFGVSPNTIDAWVRAGAPVAVIEGRKFYGKESITNWLKQHEEPEGSTKKTVSAKLGQRPLTVL
>NZ_CP018216.1|WP_072547447.1|1119391_1119709_+|hypothetical-protein
MTENIFTKQEQQVLACIPRGEKNAKKVKTIILQSGCNTRDLYETRESLLNKGVPIGSLRHPPYGWFIPATKEEAKRGLLEYSSQAATMNKNLAIFKAAMKKEFGE
>NZ_CP018216.1|WP_072547448.1|1119705_1120569_+|hypothetical-protein
MSVYIEQGLTSKNMFISDYELEECLLRAGTVPAVNITEENCDHIKATQGCYAISGEMVKLEHGTKNIVSRDALALDLDDVSSQIADFDDLEDEIRGVLKGTWYLYPTAKNGLKGIRARLIIPLDTPANEEQYTALARGLTNYLIDQGVLTRADESSFRFGQLFGLPIRSQFTKGDLVRINRGKLLSTESYTAFIKPEKPSRAGNYPTRNGGQYYGARLLDRVFSGISEGERNNSMFELACYYVGIGVQNQAGLLNYLRLINSNYFSPPLGDDELIHVFESARKKVLN

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	KM514685	Lactobacillus phage Ldl1, complete genome	18592-18621	1	0.967
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	CP031026	Lactobacillus phage ViSo-2018a, partial genome	14170-14199	2	0.933
NZ_CP018216_1	1.12\|801991\|30\|NZ_CP018216\|CRISPRCasFinder,CRT,PILER-CR	801991-802020	30	MH617220	Phage sp. isolate ctdb404, complete genome	5360-5389	2	0.933
NZ_CP018216_1	1.16\|802255\|30\|NZ_CP018216\|CRISPRCasFinder,CRT,PILER-CR	802255-802284	30	EF455602	Lactobacillus phage LL-H, complete genome	32988-33017	2	0.933
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MN856020	Siphoviridae sp. isolate 147, complete genome	12824-12853	3	0.9
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	NZ_CP028934	Campylobacter jejuni strain FORC_083 plasmid pFORC_083_2, complete sequence	32035-32064	3	0.9
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MN855879	Siphoviridae sp. isolate 341, complete genome	1639-1668	3	0.9
NZ_CP018216_1	1.8\|801727\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801727-801756	30	CP031026	Lactobacillus phage ViSo-2018a, partial genome	2430-2459	3	0.9
NZ_CP018216_1	1.8\|801727\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801727-801756	30	KM514685	Lactobacillus phage Ldl1, complete genome	30266-30295	3	0.9
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MF612073	Klebsiella phage SopranoGao, complete genome	44514-44543	6	0.8
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MN689509	Lactococcus phage CHPC1175, complete genome	10324-10353	6	0.8
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MN689521	Lactococcus phage CHPC836, complete genome	11545-11574	6	0.8
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MN689521	Lactococcus phage CHPC836, complete genome	11716-11745	6	0.8
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MN689516	Lactococcus phage CHPC148, complete genome	10679-10708	6	0.8
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	NC_004746	Lactococcus phage 4268, complete genome	24422-24451	6	0.8
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MN689530	Lactococcus phage CHPC974, partial genome	9492-9521	6	0.8
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	AJ245616	Lactococcus lactis phage BK5-T complete genome	10757-10786	6	0.8
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	AF176025	Lactococcus phage BK5-T, complete genome	10757-10786	6	0.8
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	AF489521	Lactococcus bacteriophage 4268, complete genome	24422-24451	6	0.8
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MN855764	Siphoviridae sp. isolate 508, partial genome	48635-48664	6	0.8
NZ_CP018216_1	1.10\|801859\|30\|NZ_CP018216\|CRISPRCasFinder,CRT,PILER-CR	801859-801888	30	NZ_CP019642	Planococcus sp. Y42 plasmid unnamed2, complete sequence	62895-62924	6	0.8
NZ_CP018216_1	1.12\|801991\|30\|NZ_CP018216\|CRISPRCasFinder,CRT,PILER-CR	801991-802020	30	NC_009036	Shewanella baltica OS155 plasmid pSbal02, complete sequence	33987-34016	6	0.8
NZ_CP018216_1	1.12\|801991\|30\|NZ_CP018216\|CRISPRCasFinder,CRT,PILER-CR	801991-802020	30	NC_017578	Shewanella baltica OS117 plasmid pSBAL11703, complete sequence	70371-70400	6	0.8
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MT773557	Myoviridae sp. isolate BML_S_1 genomic sequence	87819-87848	7	0.767
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MT773557	Myoviridae sp. isolate BML_S_1 genomic sequence	97963-97992	7	0.767
NZ_CP018216_1	1.8\|801727\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801727-801756	30	NC_009621	Sinorhizobium medicae WSM419 plasmid pSMED02, complete sequence	305241-305270	7	0.767
NZ_CP018216_1	1.10\|801859\|30\|NZ_CP018216\|CRISPRCasFinder,CRT,PILER-CR	801859-801888	30	NZ_CP011275	Planctomyces sp. SH-PL62 plasmid pPL62-2, complete sequence	78303-78332	7	0.767
NZ_CP018216_1	1.10\|801859\|30\|NZ_CP018216\|CRISPRCasFinder,CRT,PILER-CR	801859-801888	30	NZ_CP049142	Pseudomonas nitroreducens strain HBP1 plasmid pPniHBP1_1, complete sequence	77546-77575	7	0.767
NZ_CP018216_1	1.10\|801859\|30\|NZ_CP018216\|CRISPRCasFinder,CRT,PILER-CR	801859-801888	30	NZ_CP011296	Rhodococcus erythropolis strain BG43 plasmid pRLCBG43, complete sequence	214503-214532	7	0.767
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MH892385	Streptococcus phage SW33, complete genome	12782-12811	8	0.733
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MH892384	Streptococcus phage SW32, complete genome	12782-12811	8	0.733
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	KY705278	Streptococcus phage P7952, complete genome	12281-12310	8	0.733
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	KY705281	Streptococcus phage P7955, complete genome	11984-12013	8	0.733
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MH892383	Streptococcus phage SW31, complete genome	12782-12811	8	0.733
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	KY705279	Streptococcus phage P7953, complete genome	12282-12311	8	0.733
NZ_CP018216_1	1.5\|801529\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801529-801558	30	MH892362	Streptococcus phage SW13, complete genome	12799-12828	8	0.733
NZ_CP018216_1	1.6\|801595\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801595-801624	30	KC182550	Lactococcus lactis phage P475, complete genome	10356-10385	8	0.733
NZ_CP018216_1	1.6\|801595\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801595-801624	30	MN694664	Marine virus AFVG_250M101, complete genome	32827-32856	8	0.733
NZ_CP018216_1	1.6\|801595\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801595-801624	30	MN694569	Marine virus AFVG_250M103, complete genome	33052-33081	8	0.733
NZ_CP018216_1	1.7\|801661\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801661-801690	30	KC182550	Lactococcus lactis phage P475, complete genome	10356-10385	8	0.733
NZ_CP018216_1	1.7\|801661\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801661-801690	30	MN694664	Marine virus AFVG_250M101, complete genome	32827-32856	8	0.733
NZ_CP018216_1	1.7\|801661\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801661-801690	30	MN694569	Marine virus AFVG_250M103, complete genome	33052-33081	8	0.733
NZ_CP018216_1	1.10\|801859\|30\|NZ_CP018216\|CRISPRCasFinder,CRT,PILER-CR	801859-801888	30	NC_030917	Gordonia phage OneUp, complete genome	11276-11305	8	0.733
NZ_CP018216_1	1.15\|802189\|30\|NZ_CP018216\|CRISPRCasFinder,CRT,PILER-CR	802189-802218	30	NZ_CP038274	Legionella israelensis strain Bercovier 4 plasmid unnamed1, complete sequence	42555-42584	8	0.733
NZ_CP018216_1	1.3\|801397\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801397-801426	30	NZ_CP013929	Alteromonas mediterranea strain UM8 plasmid pAMEDUM8_300, complete sequence	161821-161850	9	0.7
NZ_CP018216_1	1.3\|801397\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801397-801426	30	CP013931	Alteromonas mediterranea strain U10 plasmid pAMED10_300, complete sequence	166582-166611	9	0.7
NZ_CP018216_1	1.3\|801397\|30\|NZ_CP018216\|CRISPRCasFinder,CRT	801397-801426	30	NC_019394	Alteromonas mediterranea DE1 plasmid pAMDE1, complete sequence	161848-161877	9	0.7
NZ_CP018216_1	1.10\|801859\|30\|NZ_CP018216\|CRISPRCasFinder,CRT,PILER-CR	801859-801888	30	NZ_CP024312	Rhizobium sp. NXC24 plasmid pRspNXC24a, complete sequence	172103-172132	9	0.7

1. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to KM514685 (Lactobacillus phage Ldl1, complete genome) position: , mismatch: 1, identity: 0.967

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tggaagctcaaaaggctggtactggtttac	Protospacer
*************.****************

2. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to CP031026 (Lactobacillus phage ViSo-2018a, partial genome) position: , mismatch: 2, identity: 0.933

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tggaagctcaaaaggctggtactgggttac	Protospacer
*************.*********** ****

3. spacer 1.12|801991|30|NZ_CP018216|CRISPRCasFinder,CRT,PILER-CR matches to MH617220 (Phage sp. isolate ctdb404, complete genome) position: , mismatch: 2, identity: 0.933

acgtcaaaagtttacttagagttttgaagg	CRISPR spacer
atgtcaaaagtttacttagaattttgaagg	Protospacer
*.******************.*********

4. spacer 1.16|802255|30|NZ_CP018216|CRISPRCasFinder,CRT,PILER-CR matches to EF455602 (Lactobacillus phage LL-H, complete genome) position: , mismatch: 2, identity: 0.933

acagattgagttcacgattgctggggatcc	CRISPR spacer
gcagattgagttcacgattgctggggagcc	Protospacer
.************************** **

5. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MN856020 (Siphoviridae sp. isolate 147, complete genome) position: , mismatch: 3, identity: 0.9

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
ttggtgctcaaaaagctggtactggtttac	Protospacer
* *. *************************

6. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to NZ_CP028934 (Campylobacter jejuni strain FORC_083 plasmid pFORC_083_2, complete sequence) position: , mismatch: 3, identity: 0.9

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tagaagctgaaaaggctggtactggtttac	Protospacer
*.****** ****.****************

7. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MN855879 (Siphoviridae sp. isolate 341, complete genome) position: , mismatch: 3, identity: 0.9

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tggaagcacaacaagctggtactggtttgc	Protospacer
******* *** ****************.*

8. spacer 1.8|801727|30|NZ_CP018216|CRISPRCasFinder,CRT matches to CP031026 (Lactobacillus phage ViSo-2018a, partial genome) position: , mismatch: 3, identity: 0.9

aagcacacggctgaggagattagcacgacc	CRISPR spacer
aagcacacggctgaggagatcagtacgact	Protospacer
********************.**.*****.

9. spacer 1.8|801727|30|NZ_CP018216|CRISPRCasFinder,CRT matches to KM514685 (Lactobacillus phage Ldl1, complete genome) position: , mismatch: 3, identity: 0.9

aagcacacggctgaggagattagcacgacc	CRISPR spacer
aagcacacggctgaggagatcagtacgact	Protospacer
********************.**.*****.

10. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MF612073 (Klebsiella phage SopranoGao, complete genome) position: , mismatch: 6, identity: 0.8

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
acgaagctcaaaaagctggggctggtggac	Protospacer
  ***************** .*****  **

11. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MN689509 (Lactococcus phage CHPC1175, complete genome) position: , mismatch: 6, identity: 0.8

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tagaagctgataaagctggtactggacttc	Protospacer
*.****** * ************** .* *

12. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MN689521 (Lactococcus phage CHPC836, complete genome) position: , mismatch: 6, identity: 0.8

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tagaagctgataaagctggtactggacttc	Protospacer
*.****** * ************** .* *

13. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MN689521 (Lactococcus phage CHPC836, complete genome) position: , mismatch: 6, identity: 0.8

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tagaagctgataaagctggtactggacttc	Protospacer
*.****** * ************** .* *

14. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MN689516 (Lactococcus phage CHPC148, complete genome) position: , mismatch: 6, identity: 0.8

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tagaagctgataaagctggtactggacttc	Protospacer
*.****** * ************** .* *

15. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to NC_004746 (Lactococcus phage 4268, complete genome) position: , mismatch: 6, identity: 0.8

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tagaagctgataaagctggtactggacttc	Protospacer
*.****** * ************** .* *

16. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MN689530 (Lactococcus phage CHPC974, partial genome) position: , mismatch: 6, identity: 0.8

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tagaagctgataaagctggtactggacttc	Protospacer
*.****** * ************** .* *

17. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to AJ245616 (Lactococcus lactis phage BK5-T complete genome) position: , mismatch: 6, identity: 0.8

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tagaagctgataaagctggtactggacttc	Protospacer
*.****** * ************** .* *

18. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to AF176025 (Lactococcus phage BK5-T, complete genome) position: , mismatch: 6, identity: 0.8

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tagaagctgataaagctggtactggacttc	Protospacer
*.****** * ************** .* *

19. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to AF489521 (Lactococcus bacteriophage 4268, complete genome) position: , mismatch: 6, identity: 0.8

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
tagaagctgataaagctggtactggacttc	Protospacer
*.****** * ************** .* *

20. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MN855764 (Siphoviridae sp. isolate 508, partial genome) position: , mismatch: 6, identity: 0.8

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
ttggcgctcaaaaagcgggtactggattgc	Protospacer
* *. *********** ******** **.*

21. spacer 1.10|801859|30|NZ_CP018216|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP019642 (Planococcus sp. Y42 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.8

gtactcttcctggatcttctcctggtccag	CRISPR spacer
ggtcacttgctggatcttctgctggtcctg	Protospacer
*  * *** *********** ******* *

22. spacer 1.12|801991|30|NZ_CP018216|CRISPRCasFinder,CRT,PILER-CR matches to NC_009036 (Shewanella baltica OS155 plasmid pSbal02, complete sequence) position: , mismatch: 6, identity: 0.8

acgtcaaaagtttacttagagttttgaagg	CRISPR spacer
agattaataatttacttagagttttgaagc	Protospacer
* .*.** *.*******************

23. spacer 1.12|801991|30|NZ_CP018216|CRISPRCasFinder,CRT,PILER-CR matches to NC_017578 (Shewanella baltica OS117 plasmid pSBAL11703, complete sequence) position: , mismatch: 6, identity: 0.8

acgtcaaaagtttacttagagttttgaagg	CRISPR spacer
agattaataatttacttagagttttgaagc	Protospacer
* .*.** *.*******************

24. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MT773557 (Myoviridae sp. isolate BML_S_1 genomic sequence) position: , mismatch: 7, identity: 0.767

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
ttcgaggagaagaagctggtactggtttac	Protospacer
*  .**   **.******************

25. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MT773557 (Myoviridae sp. isolate BML_S_1 genomic sequence) position: , mismatch: 7, identity: 0.767

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
ttcgaggagaagaagctggtactggtttac	Protospacer
*  .**   **.******************

26. spacer 1.8|801727|30|NZ_CP018216|CRISPRCasFinder,CRT matches to NC_009621 (Sinorhizobium medicae WSM419 plasmid pSMED02, complete sequence) position: , mismatch: 7, identity: 0.767

aagcacacggctgaggagattagcacgacc	CRISPR spacer
tccggcacggctgaggagattcgctcgacc	Protospacer
    .**************** ** *****

27. spacer 1.10|801859|30|NZ_CP018216|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP011275 (Planctomyces sp. SH-PL62 plasmid pPL62-2, complete sequence) position: , mismatch: 7, identity: 0.767

gtactcttcctggatcttctcctggtccag	CRISPR spacer
tacctcttcctggatcatctcctgggcccc	Protospacer
   ************* ******** **

28. spacer 1.10|801859|30|NZ_CP018216|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP049142 (Pseudomonas nitroreducens strain HBP1 plasmid pPniHBP1_1, complete sequence) position: , mismatch: 7, identity: 0.767

gtactcttcctggatcttctcctggtccag	CRISPR spacer
caccaattcctggatcttctccttgtcgag	Protospacer
   *  ***************** *** **

29. spacer 1.10|801859|30|NZ_CP018216|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP011296 (Rhodococcus erythropolis strain BG43 plasmid pRLCBG43, complete sequence) position: , mismatch: 7, identity: 0.767

-gtactcttcctggatcttctcctggtccag	CRISPR spacer
catgcgctcctt-gatcttctcctggtcctg	Protospacer
 .*.* **.*.* **************** *

30. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MH892385 (Streptococcus phage SW33, complete genome) position: , mismatch: 8, identity: 0.733

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
cagctgctcaaaaagcgggtattggtttca	Protospacer
..*  *********** ****.******

31. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MH892384 (Streptococcus phage SW32, complete genome) position: , mismatch: 8, identity: 0.733

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
cagctgctcaaaaagcgggtattggtttca	Protospacer
..*  *********** ****.******

32. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to KY705278 (Streptococcus phage P7952, complete genome) position: , mismatch: 8, identity: 0.733

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
cagctgctcaaaaagcgggtattggtttca	Protospacer
..*  *********** ****.******

33. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to KY705281 (Streptococcus phage P7955, complete genome) position: , mismatch: 8, identity: 0.733

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
cagctgctcaaaaagcgggtattggtttca	Protospacer
..*  *********** ****.******

34. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MH892383 (Streptococcus phage SW31, complete genome) position: , mismatch: 8, identity: 0.733

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
cagctgctcaaaaagcgggtattggtttca	Protospacer
..*  *********** ****.******

35. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to KY705279 (Streptococcus phage P7953, complete genome) position: , mismatch: 8, identity: 0.733

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
cagctgctcaaaaagcgggtattggtttca	Protospacer
..*  *********** ****.******

36. spacer 1.5|801529|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MH892362 (Streptococcus phage SW13, complete genome) position: , mismatch: 8, identity: 0.733

tggaagctcaaaaagctggtactggtttac	CRISPR spacer
cagctgctcaaaaagcgggtattggtttca	Protospacer
..*  *********** ****.******

37. spacer 1.6|801595|30|NZ_CP018216|CRISPRCasFinder,CRT matches to KC182550 (Lactococcus lactis phage P475, complete genome) position: , mismatch: 8, identity: 0.733

ccacttacgctactgttttaccaactaaga	CRISPR spacer
ttactaacgcttctgttttaccaactgctg	Protospacer
..*** ***** **************.  .

38. spacer 1.6|801595|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MN694664 (Marine virus AFVG_250M101, complete genome) position: , mismatch: 8, identity: 0.733

ccacttacgctactgttttaccaactaaga	CRISPR spacer
ctttttccgctactgttttaccaacagcgt	Protospacer
*. .** ****************** . *

39. spacer 1.6|801595|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MN694569 (Marine virus AFVG_250M103, complete genome) position: , mismatch: 8, identity: 0.733

ccacttacgctactgttttaccaactaaga	CRISPR spacer
ctttttccgctactgttttaccaacagcgt	Protospacer
*. .** ****************** . *

40. spacer 1.7|801661|30|NZ_CP018216|CRISPRCasFinder,CRT matches to KC182550 (Lactococcus lactis phage P475, complete genome) position: , mismatch: 8, identity: 0.733

ccacttacgctactgttttaccaactaaga	CRISPR spacer
ttactaacgcttctgttttaccaactgctg	Protospacer
..*** ***** **************.  .

41. spacer 1.7|801661|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MN694664 (Marine virus AFVG_250M101, complete genome) position: , mismatch: 8, identity: 0.733

ccacttacgctactgttttaccaactaaga	CRISPR spacer
ctttttccgctactgttttaccaacagcgt	Protospacer
*. .** ****************** . *

42. spacer 1.7|801661|30|NZ_CP018216|CRISPRCasFinder,CRT matches to MN694569 (Marine virus AFVG_250M103, complete genome) position: , mismatch: 8, identity: 0.733

ccacttacgctactgttttaccaactaaga	CRISPR spacer
ctttttccgctactgttttaccaacagcgt	Protospacer
*. .** ****************** . *

43. spacer 1.10|801859|30|NZ_CP018216|CRISPRCasFinder,CRT,PILER-CR matches to NC_030917 (Gordonia phage OneUp, complete genome) position: , mismatch: 8, identity: 0.733

gtactcttcctggatcttctcctggtccag	CRISPR spacer
gactgcttcctggaacttcttctggtcctc	Protospacer
*  . ********* *****.*******

44. spacer 1.15|802189|30|NZ_CP018216|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP038274 (Legionella israelensis strain Bercovier 4 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

aaggagttttttcaatgagcctggcaatcc	CRISPR spacer
aaggagatttttaaatgagcctgaataaat	Protospacer
****** ***** **********.  *  .

45. spacer 1.3|801397|30|NZ_CP018216|CRISPRCasFinder,CRT matches to NZ_CP013929 (Alteromonas mediterranea strain UM8 plasmid pAMEDUM8_300, complete sequence) position: , mismatch: 9, identity: 0.7

cactctgcttgaccaagtcttgcattgtct	CRISPR spacer
tgggatgcttgatcaagtcttgcattttga	Protospacer
..   *******.************* *

46. spacer 1.3|801397|30|NZ_CP018216|CRISPRCasFinder,CRT matches to CP013931 (Alteromonas mediterranea strain U10 plasmid pAMED10_300, complete sequence) position: , mismatch: 9, identity: 0.7

cactctgcttgaccaagtcttgcattgtct	CRISPR spacer
tgggatgcttgatcaagtcttgcattttga	Protospacer
..   *******.************* *

47. spacer 1.3|801397|30|NZ_CP018216|CRISPRCasFinder,CRT matches to NC_019394 (Alteromonas mediterranea DE1 plasmid pAMDE1, complete sequence) position: , mismatch: 9, identity: 0.7

cactctgcttgaccaagtcttgcattgtct	CRISPR spacer
tgggatgcttgatcaagtcttgcattttga	Protospacer
..   *******.************* *

48. spacer 1.10|801859|30|NZ_CP018216|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP024312 (Rhizobium sp. NXC24 plasmid pRspNXC24a, complete sequence) position: , mismatch: 9, identity: 0.7

gtactcttcctggatcttctcctggtccag	CRISPR spacer
cagctcttccttgatcttctcctgccctgc	Protospacer
  .******** ************ .*..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

162285 : 298408

104

Bacillus_virus(11.43%)

tRNA,transposase,protease,bacteriocin

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_072546928.1\|162285_162747_-\|transposase	IS200/IS605 family transposase	A0A0P0IQC6	Lactobacillus_phage	8.2e-40	58.1
WP_072546929.1\|162813_164226_+\|transposase	transposase	A0A2I7RKG5	Vibrio_phage	3.8e-11	34.6
WP_072546930.1\|164558_166181_+	alpha-glucosidase	NA	NA	NA	NA
WP_072546931.1\|166330_167290_+	LacI family transcriptional regulator	C6ZCU4	Enterobacteria_phage	1.2e-11	23.6
WP_002877818.1\|167408_169064_+	alpha-glucosidase	NA	NA	NA	NA
WP_072546932.1\|169125_170829_+	alpha-glycosidase	NA	NA	NA	NA
WP_072546933.1\|170922_173199_+	glycoside hydrolase family 65 protein	NA	NA	NA	NA
WP_072546934.1\|173183_173849_+	beta-phosphoglucomutase	A0A1D8KNV9	Synechococcus_phage	6.5e-06	26.1
WP_072546935.1\|173859_174966_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	3.7e-22	31.6
WP_072546936.1\|175073_176291_+	extracellular solute-binding protein	NA	NA	NA	NA
WP_072546937.1\|176344_177703_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_072546938.1\|177705_178563_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_072546939.1\|178714_181720_-	alpha-glucosidase	NA	NA	NA	NA
WP_072546941.1\|182650_184063_+\|transposase	transposase	A0A2I7RKG5	Vibrio_phage	3.8e-11	34.6
WP_072546942.1\|184495_185644_+	N-acetylglucosamine-6-phosphate deacetylase	NA	NA	NA	NA
WP_002877839.1\|185714_186188_-	nucleoside deoxyribosyltransferase	A0A0A7DMT2	Lactobacillus_phage	7.3e-60	69.5
WP_072546943.1\|187040_188591_+\|transposase	transposase	NA	NA	NA	NA
WP_072546944.1\|188978_189458_+	PTS sugar transporter subunit IIA	NA	NA	NA	NA
WP_072546945.1\|189467_190265_-	tyrosine-protein phosphatase	NA	NA	NA	NA
WP_003611675.1\|190461_190935_+	universal stress protein	NA	NA	NA	NA
WP_072546946.1\|192415_193186_+	phosphonate ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.3e-25	34.9
WP_072546947.1\|193188_193989_+	phosphonate ABC transporter, permease protein PhnE	NA	NA	NA	NA
WP_072546948.1\|193988_194801_+	phosphonate ABC transporter, permease protein PhnE	NA	NA	NA	NA
WP_155760710.1\|195056_196565_-	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_072546949.1\|196937_197423_+	hypothetical protein	NA	NA	NA	NA
WP_002877852.1\|197480_198881_+	hypothetical protein	NA	NA	NA	NA
WP_002877854.1\|198977_200927_+	asparagine synthase (glutamine-hydrolyzing)	R4TIC1	Phaeocystis_globosa_virus	4.9e-25	28.6
WP_072546950.1\|200960_202220_+	carboxylate--amine ligase	NA	NA	NA	NA
WP_072546951.1\|202585_204796_+	anaerobic ribonucleoside-triphosphate reductase	A0A0C5KKX3	Enterococcus_phage	1.2e-250	59.9
WP_003614463.1\|204867_205590_+	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A288TZV3	Enterococcus_phage	1.3e-47	54.6
WP_072546952.1\|205608_206166_+	DUF59 domain-containing protein	NA	NA	NA	NA
WP_072546953.1\|206165_207482_+	DUF438 domain-containing protein	NA	NA	NA	NA
WP_002877867.1\|207581_208802_+	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	8.5e-52	33.2
WP_072546954.1\|208888_209227_+	glutaredoxin	NA	NA	NA	NA
WP_072546955.1\|209251_211204_+	peptidase M13	E3T4I7	Cafeteria_roenbergensis_virus	5.0e-70	29.7
WP_072546956.1\|211539_213561_-	KUP/HAK/KT family potassium transporter	M1IBC2	Acanthocystis_turfacea_Chlorella_virus	4.1e-67	33.9
WP_044880580.1\|213716_214091_-	hypothetical protein	NA	NA	NA	NA
WP_072546957.1\|214246_215194_-	hypothetical protein	NA	NA	NA	NA
WP_072546958.1\|215407_215617_+	DUF1659 domain-containing protein	NA	NA	NA	NA
WP_002877881.1\|215676_215913_+	DUF2922 domain-containing protein	NA	NA	NA	NA
WP_072546960.1\|216183_217386_+	amidase	Q9ZXE4	Bacillus_phage	3.6e-10	40.5
WP_072546961.1\|218931_220770_+	potassium transporter	NA	NA	NA	NA
WP_072546962.1\|220881_221847_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_072546963.1\|221888_222638_-	hypothetical protein	NA	NA	NA	NA
WP_002877893.1\|222801_223491_+	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	NA	NA	NA	NA
WP_072546964.1\|223741_225055_+	LytR family transcriptional regulator	NA	NA	NA	NA
WP_072546965.1\|225057_225675_+	hypothetical protein	NA	NA	NA	NA
WP_072546966.1\|225753_228756_+	LTA synthase family protein	NA	NA	NA	NA
WP_072546874.1\|228917_230291_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_072546967.1\|230487_231549_+	acyltransferase family protein	NA	NA	NA	NA
WP_072546968.1\|231806_233072_+\|tRNA	tyrosine--tRNA ligase	K4F5T3	Cronobacter_phage	1.9e-83	41.7
WP_081369558.1\|233398_234247_-\|transposase	transposase	NA	NA	NA	NA
WP_072546969.1\|234953_235136_+	cytochrome C551	NA	NA	NA	NA
WP_072546970.1\|235595_235751_-\|transposase	transposase	NA	NA	NA	NA
WP_072546971.1\|235917_236568_+	HD domain-containing protein	NA	NA	NA	NA
WP_072546972.1\|238171_239788_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_072546973.1\|240017_241646_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_072546974.1\|241875_243504_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_072546975.1\|243732_245379_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_072546976.1\|245805_246726_+	ABC transporter permease	NA	NA	NA	NA
WP_072546977.1\|246747_247779_+	ABC transporter permease	NA	NA	NA	NA
WP_002877218.1\|247792_248836_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.7e-19	32.2
WP_072544251.1\|248850_249804_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.6e-21	33.8
WP_003612928.1\|250150_251464_-	aminopeptidase	R4TV59	Phaeocystis_globosa_virus	4.4e-62	32.5
WP_072546978.1\|251515_252829_-	aminopeptidase	R4TV59	Phaeocystis_globosa_virus	2.8e-61	33.3
WP_002877230.1\|252925_253339_-	Hsp20/alpha crystallin family protein	NA	NA	NA	NA
WP_002877232.1\|253566_254028_+	transcription elongation factor GreA	NA	NA	NA	NA
WP_002877233.1\|254111_255401_-	adenylosuccinate synthase	L7Y4J5	Megavirus	3.5e-72	37.8
WP_072546979.1\|255586_256579_+	GMP reductase	Q4ZCY7	Staphylococcus_virus	8.0e-133	68.4
WP_072546980.1\|257861_258113_+	hypothetical protein	NA	NA	NA	NA
WP_072546981.1\|258182_259475_-	purine permease	Q9KX94	Enterobacteria_phage	2.2e-29	30.9
WP_013439051.1\|259504_260074_-	xanthine phosphoribosyltransferase	NA	NA	NA	NA
WP_072546982.1\|260428_261586_+	guanosine monophosphate reductase	A0A1V0SHK8	Klosneuvirus	4.3e-61	32.1
WP_072546983.1\|261585_263139_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	3.0e-17	29.1
WP_072546984.1\|263283_264894_+	ABC transporter ATP-binding protein	A0A076FI99	Aureococcus_anophage	1.4e-17	27.7
WP_035164529.1\|264930_265773_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013439055.1\|265929_267402_+	glycoside hydrolase family 1 protein	A0A0B5JD41	Pandoravirus	1.4e-24	24.9
WP_081369528.1\|267557_268037_-\|transposase	transposase	NA	NA	NA	NA
WP_081369529.1\|267979_268930_-\|transposase	transposase	NA	NA	NA	NA
WP_072546985.1\|269117_270380_-	carboxylate--amine ligase	NA	NA	NA	NA
WP_072546986.1\|270473_271439_-	Crp/Fnr family transcriptional regulator	A0A1B3AYT3	Gordonia_phage	2.8e-05	31.7
WP_072546987.1\|271594_272989_-	amino acid permease	NA	NA	NA	NA
WP_072546988.1\|273065_273998_+	homocysteine S-methyltransferase	NA	NA	NA	NA
WP_072546989.1\|274566_275013_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_072546990.1\|274994_276017_+	asparaginase	NA	NA	NA	NA
WP_099279071.1\|276133_276772_+	HAD-IIB family hydrolase	NA	NA	NA	NA
WP_072546991.1\|276857_277334_+	large conductance mechanosensitive channel protein MscL	NA	NA	NA	NA
WP_035160951.1\|279073_280507_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	1.5e-103	45.3
WP_002878752.1\|280575_281130_-	cysteine hydrolase	G3MA16	Bacillus_virus	4.0e-33	39.1
WP_002878751.1\|281382_282240_+	hypothetical protein	NA	NA	NA	NA
WP_072546992.1\|282232_282499_-	DUF1294 domain-containing protein	NA	NA	NA	NA
WP_072546993.1\|282715_284089_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_072546994.1\|284259_285030_-	NUDIX hydrolase	G3MA14	Bacillus_virus	1.3e-10	25.8
WP_072546996.1\|286735_287023_+\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_003614028.1\|287210_287462_+	hypothetical protein	NA	NA	NA	NA
WP_072546997.1\|288223_289024_-	ABC transporter permease	NA	NA	NA	NA
WP_002878739.1\|289020_289731_-	ATP-binding cassette domain-containing protein	A0A2R8FG22	Brazilian_cedratvirus	3.0e-17	32.8
WP_072546998.1\|289855_290104_+	hypothetical protein	NA	NA	NA	NA
WP_072546999.1\|290147_290816_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_072547000.1\|291137_292163_+\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_035183896.1\|292164_292647_+	competence protein ComE	A7KUY9	Bacillus_phage	5.4e-34	55.5
WP_072547001.1\|292627_293242_+	methanol dehydrogenase	NA	NA	NA	NA
WP_072547002.1\|293599_296290_+	magnesium-translocating P-type ATPase	M1HJQ2	Paramecium_bursaria_Chlorella_virus	6.7e-41	25.4
WP_072547003.1\|296425_298408_+\|tRNA	methionine--tRNA ligase	A0A1V0SHR2	Klosneuvirus	5.0e-94	37.2

DBSCAN-SWA_2

1679055 : 1687009

Enterobacteria_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_072547753.1\|1679055_1679490_+	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	4.7e-05	35.5
WP_013440186.1\|1679541_1679967_-	peptide-methionine (R)-S-oxide reductase MsrB	NA	NA	NA	NA
WP_016396236.1\|1680819_1681794_-	dTDP-4-dehydrorhamnose reductase	A0A140G5S3	Enterobacteria_phage	1.2e-29	35.5
WP_035185083.1\|1681808_1682417_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	7.2e-44	56.1
WP_072547754.1\|1682443_1683328_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	2.7e-92	58.2
WP_072547755.1\|1683347_1684385_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	1.8e-87	48.0
WP_072547756.1\|1684509_1685682_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_013440192.1\|1685768_1686293_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_013440193.1\|1686304_1687009_-	aquaporin family protein	M1HWZ0	Paramecium_bursaria_Chlorella_virus	1.3e-28	32.5

DBSCAN-SWA_3

1736334 : 1744824

Clostridioides_phage(22.22%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_072547785.1\|1736334_1737114_-	hydrolase	A0A1V0DZX6	Clostridioides_phage	1.4e-07	36.9
WP_072547786.1\|1737159_1737918_-	C40 family peptidase	A0A0A8WF62	Clostridium_phage	5.2e-15	40.2
WP_072547787.1\|1738210_1738924_-	C40 family peptidase	A0A0A7DMV4	Lactobacillus_phage	8.0e-18	52.9
WP_072547788.1\|1739287_1740511_+\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	4.8e-95	48.0
WP_072547789.1\|1740735_1741518_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	2.0e-14	42.7
WP_072547790.1\|1741705_1742179_-	C40 family peptidase	A0A1V0DZX6	Clostridioides_phage	1.6e-14	38.8
WP_072547791.1\|1742348_1743395_-	lactate dehydrogenase	M1H502	Paramecium_bursaria_Chlorella_virus	3.3e-28	29.7
WP_003611214.1\|1743679_1744165_-	C40 family peptidase	A0A2L1IW19	Streptomyces_phage	3.3e-15	40.4
WP_072547792.1\|1744272_1744824_-	AAA family ATPase	U5J9X2	Bacillus_phage	1.3e-12	35.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP018216

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection