CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP018151	Microbacterium sp. 1.5R chromosome, complete genome	3 crisprs	csa3,cas3,DEDDh,WYL	0	0	0	0

Cas Category Instructions

Results visualization

1. NZ_CP018151

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018151_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018151_1

2276305-2276391

Orphan

Consensus_repeat	Method
CTGAGCGCAGCACACGTCACGCTGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018151_1

>merge|NZ_CP018151|1|2276305-2276391|CRISPRCasFinder
CTGAGCGCAGCACACGTCACGCTGAGTGCGGCACCCTCACGCTGAGCGCAGCATCCTCACGCTGAGCGCAGCACGCGTCACGCTGAG

>NZ_CP018151|1|1|2276305-2276391|CRISPRCasFinder
CTGAGCGCAGCACACGTCACGCTGAG	TGCGGCACCCTCACGCTGAGCGCAGCATCCTCACG
CTGAGCGCAGCACGCGTCACGCTGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018151.1\|WP_072591477.1\|2269834_2270128_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018151.1\|WP_053099169.1\|2283245_2284079_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|379293
NZ_CP018151.1\|WP_157557428.1\|2271319_2271466_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018151.1\|WP_072591478.1\|2271508_2271742_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018151.1\|WP_072591482.1\|2274428_2274815_+\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|224109
NZ_CP018151.1\|WP_072591487.1\|2284235_2285138_-\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|234713
NZ_CP018151.1\|WP_056278985.1\|2271701_2271995_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018151.1\|WP_072591479.1\|2272465_2273050_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP018151.1\|WP_072591480.1\|2273046_2273244_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|181104
NZ_CP018151.1\|WP_072591485.1\|2279069_2279744_-\|(d)CMP-kinase	unknown	unknown	gnl\|CDD\|236546
NZ_CP018151.1\|WP_053096842.1\|2277556_2279077_-\|ribosome-biogenesis-GTPase-Der	unknown	unknown	gnl\|CDD\|179525
NZ_CP018151.1\|WP_072591486.1\|2281743_2282346_-\|SMC-Scp-complex-subunit-ScpB	unknown	unknown	gnl\|CDD\|377219
NZ_CP018151.1\|WP_083569352.1\|2279736_2280882_-\|prephenate-dehydrogenase	unknown	unknown	gnl\|CDD\|235824
NZ_CP018151.1\|WP_072591484.1\|2276509_2277448_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|366006
NZ_CP018151.1\|WP_072591481.1\|2273760_2274429_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377946
NZ_CP018151.1\|WP_053096828.1\|2270183_2270459_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018151.1\|WP_056278993.1\|2280878_2281667_-\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108
NZ_CP018151.1\|WP_072592317.1\|2282335_2283154_-\|segregation/condensation-protein-A	unknown	unknown	gnl\|CDD\|224273
NZ_CP018151.1\|WP_056278988.1\|2273264_2273720_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018151.1\|WP_053099170.1\|2285140_2285719_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239516

Protein	Function_ID	Function_description	E-value
NZ_CP018151.1\|WP_072591482.1\|2274428_2274815_+\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	3.55475e-21
NZ_CP018151.1\|WP_072591487.1\|2284235_2285138_-\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|234713	PRK00283, xerD, tyrosine recombinase.	1.41038e-145
NZ_CP018151.1\|WP_072591479.1\|2272465_2273050_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	9.50132e-07
NZ_CP018151.1\|WP_072591480.1\|2273046_2273244_+\|hypothetical-protein	gnl\|CDD\|181104	PRK07758, PRK07758, hypothetical protein; Provisional.	6.89524e-07
NZ_CP018151.1\|WP_072591485.1\|2279069_2279744_-\|(d)CMP-kinase	gnl\|CDD\|236546	PRK09518, PRK09518, bifunctional cytidylate kinase/GTPase Der; Reviewed.	2.89165e-68
NZ_CP018151.1\|WP_072591486.1\|2281743_2282346_-\|SMC-Scp-complex-subunit-ScpB	gnl\|CDD\|377219	pfam04079, SMC_ScpB, Segregation and condensation complex subunit ScpB. This is a family of prokaryotic proteins that form one of the subunits, ScpB, of the segregation and condensation complex, condensin, that plays a key role in the maintenance of the chromosome. In prokaryotes the complex consists of three proteins, SMC, ScpA (kleisin) and ScpB. ScpB dimerizes and binds to ScpA. As originally predicted, ScpB is structurally a winged-helix at both its N- and C-terminal halves. IN Bacillus subtilis,one Smc dimer is bridged by a single ScpAB to generate asymmetric tripartite rings analogous to eukaryotic SMC complex ring-shaped assemblies.	8.33837e-57
NZ_CP018151.1\|WP_083569352.1\|2279736_2280882_-\|prephenate-dehydrogenase	gnl\|CDD\|235824	PRK06545, PRK06545, prephenate dehydrogenase; Validated.	1.10087e-117
NZ_CP018151.1\|WP_072591484.1\|2276509_2277448_-\|NUDIX-hydrolase	gnl\|CDD\|366006	pfam00293, NUDIX, NUDIX domain.	9.96937e-12
NZ_CP018151.1\|WP_053096842.1\|2277556_2279077_-\|ribosome-biogenesis-GTPase-Der	gnl\|CDD\|179525	PRK03003, PRK03003, GTP-binding protein Der; Reviewed.	0
NZ_CP018151.1\|WP_072591481.1\|2273760_2274429_+\|hypothetical-protein	gnl\|CDD\|377946	pfam07947, YhhN, YhhN family. The members of this family are similar to the hypothetical protein yhhN expressed by E. coli. Many are annotated as possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues. A human member of this family, formerly known as TMEM86B, is a lysoplasmalogenase that catalyzes the hydrolysis of the vinyl ether bond of lysoplasmalogen. Putative conserved active site residues have been proposed for the YhhN family.	3.27665e-13
NZ_CP018151.1\|WP_056278993.1\|2280878_2281667_-\|rRNA-pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	1.96767e-85
NZ_CP018151.1\|WP_053099169.1\|2283245_2284079_-\|ParA-family-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	2.12437e-84
NZ_CP018151.1\|WP_072592317.1\|2282335_2283154_-\|segregation/condensation-protein-A	gnl\|CDD\|224273	COG1354, scpA, Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair].	4.56281e-44
NZ_CP018151.1\|WP_053099170.1\|2285140_2285719_-\|NUDIX-hydrolase	gnl\|CDD\|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	2.91658e-44

>NZ_CP018151.1|WP_072591482.1|2274428_2274815_+|RNA-binding-S4-domain-containing-protein
MADAARVDSWLWAIRVYKTRSAATTACRAGHVRMNGDKVKAAQHIRVGDELRIRIAGFDRILIVRQLLVKRVGAPLAALAYEDRTPEREPQAALGLRDRGAGRPTKRERRDIDKLRGRGYEDDGIFQG
>NZ_CP018151.1|WP_072591481.1|2273760_2274429_+|hypothetical-protein
MQRRRRSDPLLWAFLPYAAASAAHVALLSVGSPAAGPTKLLLMPLLAVPVFVSVGRAAERSALALTIAALLFSWLGDSAGVFFPAAPEVPLMLLFFGIAHLAYIALFMRHLAARRMPWWALVYAAWWVVMLVFIGPHAGGLLIAVAVYGLVLASTAAAATRCSALVSIGGAFFLASDTLLALRLFLPGSLPDWSSPAIMATYTLGQGLIIAGTLIALRKRDI
>NZ_CP018151.1|WP_056278988.1|2273264_2273720_+|hypothetical-protein
MSDENPTIEDPELGTLTRATTELSDGTVLTHDWYAGGTVVAAAPLDLMIEGTDAGEAAALLPHVHQTIAALGVLRRLATDAVVAAFSNAAPEQHELDDAATDLTLETLEASSDGTVVLHFIDTCGQHFPEGYWPAVHLGADGQITQVTVES
>NZ_CP018151.1|WP_072591480.1|2273046_2273244_+|hypothetical-protein
MNEETDLPASMGKVARRGLALHGFTRLDQFDDASEAALLAIHGVGPKAIRILREHLESRGSTLGP
>NZ_CP018151.1|WP_072591479.1|2272465_2273050_+|GNAT-family-N-acetyltransferase
MVTITTEVATSARWDDVQHALTGGGDGASCQCIWPMLSNKEWNETTTPQRIEMLHDEIQAGPPPGLIAYIDGEAAGWIRIGPRTLQQRVPRTRMIAAASTEPFDDESVWAVTCFVVRREHRGLGITLELLRAAVDLARRSGAGLVEGYPVDTRGEKKRTNDLFHGTLATFLAAGFEERAEMKPGRTLVALDLSS
>NZ_CP018151.1|WP_056278985.1|2271701_2271995_-|hypothetical-protein
MNIADPHGPMSPYGKVGSIVNVVMSAVFGGIAVVVGIVIGEPMPFVGGLGFWAMCAFAFVPIMRRAIKYERETNARRAGAIASPHEDIPNRGDRTLD
>NZ_CP018151.1|WP_072591478.1|2271508_2271742_-|hypothetical-protein
MRTYPTVEIALWTEDAIVLMDWLETVDFDEVPSEHKAVKQALTDLASRLEEVVPYESPMTPERVATAQEAVSRGMGR
>NZ_CP018151.1|WP_157557428.1|2271319_2271466_+|hypothetical-protein
MSADKIDRVRHRRELGISIERLLFMADDADSSGHRQFYGIGGRPGIIS
>NZ_CP018151.1|WP_053096828.1|2270183_2270459_+|hypothetical-protein
MLIALIRPIETSTADVIGTTLAEVLVELEQHRKPGFYLTSAPVRMLKGEAKMEATGTFTRVDGVREIEADDMASLEAKVPEGWRMLTVRTA
>NZ_CP018151.1|WP_072591477.1|2269834_2270128_+|hypothetical-protein
MSAMPDPRFELRRVTETEWLIVDHRYEPHDARQTVACIYQVDAVEVDVLWLRNLPLASSYMSAEEVLSDLQRFHNPPSRSTSPVTIPHLPPLATTVS
>NZ_CP018151.1|WP_072591484.1|2276509_2277448_-|NUDIX-hydrolase
MTVVPPAAGEPRRPDGPRNPGDAWVIAPSGEKYWGRFGAAGLLAVDPERGILLQHRVSWSHFGGTWGLPGGAMHEGESAIVGAVREAQEEAGVPDAAVRPRFTSVLDLDVWSYTTVIADVVRPFDPVISDPESVALEWVPVDEVDARPLHPGFGSAWPALRTLLDVRLSLVVDAANVVGSVPNGWWRDRAGATARLASRLDGLAVPAADLGVGGATWFPEIALVVEGQARGIVTPSSDADAEVPELLPAGGVSIVRAEGAGDEAIVAEVERRTRAGQHVVVISSDRELQNRVDVAGAAQVRSAGWLLSVLPQ
>NZ_CP018151.1|WP_053096842.1|2277556_2279077_-|ribosome-biogenesis-GTPase-Der
MADDEYEGGPDQLAEKMESLDEQLAEARAETLRAGLADYDLDDEDAALLAGITMGEDGIQFFPALPVVAIVGRPNVGKSALVNRILGRREAVVEDTPGVTRDRVTYKAEWADRRFSLVDTGGWEPDARGIDRSVAAQAEVAIDLADIVLFVVDAMVGATSTDEHVVKLLRKSGKPVFLVANKIDDARQEPEAAALWNLGLGEPYPVSAIHGRGVADLLDQLLKKLPDVSAVAKAEIGGPRRVAILGRPNVGKSSLLNKAAGEERVVVNDLAGTTRDPVDEIVELGGKLWRLVDTAGIRRRVHMAQGADFYASLRTSAALEKAEVAVVVLDVSETISEQDVRIIDLVLESGRSLVLAFNKWDRLNDDDLENADRRRYLEREIEQDLAHVAWAPRVNISAKTGRHLDKLVPALETALENWDRRIPTGKFNAFLAELVAEHPHPLRGGKQPRILFGTQASTRPPTFVLFTTGFLDPGYRRFIQRRLRELYEFDGTPIVINMRVREKRQR
>NZ_CP018151.1|WP_072591485.1|2279069_2279744_-|(d)CMP-kinase
MTDFIAIDGPAGSGKSSVSKAVARALGFGYLDTGSAYRALAWHVLDRGADTADAAAVLDAVSHFPVRLGLDPDDRTVLVGEVDVTDAIREPSVSSAVSGVARVPEVRDRVNRLFRTLVAEAPYPAVVVEGRDITTVVAPDAPVRILLTAAPEVRAARRAGELAGENAEAVAAALHKRDASDSAVVDFLNAADGVEVVDSTELDFTQTIDAVLAVIERIRGVHHG
>NZ_CP018151.1|WP_083569352.1|2279736_2280882_-|prephenate-dehydrogenase
MTDTTSAPTGARSSVAPRIAARLSGTVRVVGAGLLGASIGHALRAKGVDVVLADTSPAQLRLAIDYGAGRSAAEDDSPVLVVVAVPPDVTADVIESELSRFPHAVVTDVASVKLEPLHSLQHRGVDLTRYIGSHPLAGRERGGAISARADLFVGRPWVVCRDADTTATDLALVEALALDVGAMPLEMTPEEHDRSVALTSHVPQVVASLLAGRLATADEGALRLSGQGVRDTTRIAASAPELWVQILGANAGPVVEILDALASDLREVSDALRAPEAPGARRVVAETIRQGNDGVERLPGKHGQNQRFESLVVMVDDTAGQLGRLFGELGELGVNVEDLRLEHSPGAQFGLAEISVDPAALHGAITGLQERGWRIAGTTND
>NZ_CP018151.1|WP_056278993.1|2280878_2281667_-|rRNA-pseudouridine-synthase
MSGFETPEGIRLQKVLSAAGVASRRVIEQYIVEGRIRVNGVTVTELGRRVDPETDLIDVDGTAVQLDVSKRYVMLNKPTGVVSSMRDENDRPDLRRFTEDYEERLYNVGRLDAETSGLLVLTNDGDLAHVLAHPSFGVTKVYIAKVEGEVTAQTISKLTRGIELDDGPIAADKARLLDTSRGSSLVELTLHSGRNRIVRRMLAAVGHPVTELVRRQFGPLHLGTLPVGKTRELTKIELGALLTLSRRDSGVAEAPGEQQENE
>NZ_CP018151.1|WP_072591486.1|2281743_2282346_-|SMC-Scp-complex-subunit-ScpB
MTDDTVDAVTEPAVRDTPLSERIEAILLIIDEPIGLVALAAAVGSPVAAVRQTIETLVDDYDGKGHGPRRGFELREVGGGWRLYVREDHDDVVAEFVGGQAPARLSQAALETLAVIAYKQPVTRSQVASIRAVNVDSVVRTLLARGLITELFADSETGAINYGTTDALLQHLGINSLDELPPISPLLDDGADGFDEGTIR
>NZ_CP018151.1|WP_072592317.1|2282335_2283154_-|segregation/condensation-protein-A
MGSDIADTAPPADPGFRVSLSNFDGPFDLLLNLISKHEMDITEVSLSAVTNEFIAYLKELDDDEELDQASEFLVVAATLLDMKVAGLLPQGELVDAEAVALLEARDLLFARLLQYRAFKEVSAWFARCLQREDRRHVRAVRLDEKHRRKTPELVWSLSADDFAALALLAFAPKEIPHVGLDHLHAPLVSIREQAAIVVTLLRAAESVSFRELVAGVSEPGIVVARFISVLELYRHAALSFEQLEPLGELTLRWAADSWSDETLASLGADYDR
>NZ_CP018151.1|WP_053099169.1|2283245_2284079_-|ParA-family-protein
MGPTGRPYHGFATPAPLASHGPARIIALCNQKGGVGKTTTSINLAAALAEYGRKVLAVDFDPQGALSAGLGIQTHDVPTIYDLLLDTKRDAHDAIVHSGVEGLDVMPANIDLSAAEVHLVNEVARETILARVLRQVAGEYDVILIDCQPSLGLLTVNALTAAHGVIIPLECEFFALRGVALLIETIDKVRDRLNPSITMDGLLATMYDPRTLHSREVLERVVEAFGDDVLETVIGRTVKFPDASVSGVPITEFAPEHAAAQAYLRLARELVARGAVA
>NZ_CP018151.1|WP_072591487.1|2284235_2285138_-|site-specific-tyrosine-recombinase-XerD
MQLDRALDTYLRHVTIERGLSEHTISAYRRDLDMYLEWLVSEGVTDTAEISPAVVGRFIADRSGADPAPAATSLARLQSSVRGWHRFLAREGIEPDDPSGRLRPPKAPRRLPKALTIDQVESLLGAPSAEDPLGIRDRALLELLYATGARVSEAVGLDVDDLAHGDVLRLRGKGSKERIVPIGSFARAAVDAYLTRVRPGLAVKGRASARLFLGARGAPLSRQSAWLVIRAAAENAHITAEVSPHTLRHSFATHLLQGGADVRVVQELLGHASVATTQIYTHVSVDTLRDIYATSHPRAR
>NZ_CP018151.1|WP_053099170.1|2285140_2285719_-|NUDIX-hydrolase
MSEFDELRDEPFQPEVLQSDLVYEGAVWNVRDDRVRYGDGEIRRQYVAHTGAVAILALDDQGRVLLIQQYRHPIRHRDWELPAGLLDMPGEEPLAAAQRELAEEADLVAAHWEPLVSSWTTPGGNDEVIHVFLASGVSTANEAHARVDEEADIRVEWVPLDAAVAAVLDGRMRNGILSIGVLAAAQRLRDRS

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Crispr_ID: NZ_CP018151_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018151_2

2281664-2281767

Orphan

Consensus_repeat	Method
TCATCGGATGGTCCCTTCGTTGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018151_2

>merge|NZ_CP018151|2|2281664-2281767|CRISPRCasFinder
TCATCGGATGGTCCCTTCGTTGAAACTGATTCTGCGCGTCGTGCCGTCGCGGCCGGTCGATGCCGTCAGGACGACCGAGATCATCGGATGGTCCCTTCGTCGAA

>NZ_CP018151|2|2|2281664-2281767|CRISPRCasFinder
TCATCGGATGGTCCCTTCGTTGAA	ACTGATTCTGCGCGTCGTGCCGTCGCGGCCGGTCGATGCCGTCAGGACGACCGAGA
TCATCGGATGGTCCCTTCGTCGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018151.1\|WP_072591483.1\|2274853_2276308_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|238038
NZ_CP018151.1\|WP_072591491.1\|2292139_2293009_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367841
NZ_CP018151.1\|WP_072591480.1\|2273046_2273244_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|181104
NZ_CP018151.1\|WP_053096854.1\|2289157_2290072_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|235121
NZ_CP018151.1\|WP_072591485.1\|2279069_2279744_-\|(d)CMP-kinase	unknown	unknown	gnl\|CDD\|236546
NZ_CP018151.1\|WP_072591487.1\|2284235_2285138_-\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|234713
NZ_CP018151.1\|WP_072591479.1\|2272465_2273050_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP018151.1\|WP_072591482.1\|2274428_2274815_+\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|224109
NZ_CP018151.1\|WP_072591489.1\|2290068_2290866_-\|TlyA-family-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|224110
NZ_CP018151.1\|WP_053096852.1\|2285733_2287452_-\|CTP-synthase	unknown	unknown	gnl\|CDD\|235437
NZ_CP018151.1\|WP_053096842.1\|2277556_2279077_-\|ribosome-biogenesis-GTPase-Der	unknown	unknown	gnl\|CDD\|179525
NZ_CP018151.1\|WP_072591490.1\|2291102_2292140_-\|HAD-IIA-family-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP018151.1\|WP_083569352.1\|2279736_2280882_-\|prephenate-dehydrogenase	unknown	unknown	gnl\|CDD\|235824
NZ_CP018151.1\|WP_072591484.1\|2276509_2277448_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|366006
NZ_CP018151.1\|WP_072591481.1\|2273760_2274429_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377946
NZ_CP018151.1\|WP_053099169.1\|2283245_2284079_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|379293
NZ_CP018151.1\|WP_072592317.1\|2282335_2283154_-\|segregation/condensation-protein-A	unknown	unknown	gnl\|CDD\|224273
NZ_CP018151.1\|WP_056278988.1\|2273264_2273720_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018151.1\|WP_053099170.1\|2285140_2285719_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239516
NZ_CP018151.1\|WP_072591488.1\|2287469_2289161_-\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571

Protein	Function_ID	Function_description	E-value
NZ_CP018151.1\|WP_072591483.1\|2274853_2276308_+\|HNH-endonuclease	gnl\|CDD\|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	4.24096e-08
NZ_CP018151.1\|WP_072591491.1\|2292139_2293009_-\|hypothetical-protein	gnl\|CDD\|367841	pfam04147, Nop14, Nop14-like family. Emg1 and Nop14 are novel proteins whose interaction is required for the maturation of the 18S rRNA and for 40S ribosome production.	6.30127e-07
NZ_CP018151.1\|WP_072591480.1\|2273046_2273244_+\|hypothetical-protein	gnl\|CDD\|181104	PRK07758, PRK07758, hypothetical protein; Provisional.	6.89524e-07
NZ_CP018151.1\|WP_053096854.1\|2289157_2290072_-\|NAD-kinase	gnl\|CDD\|235121	PRK03372, ppnK, inorganic polyphosphate/ATP-NAD kinase; Provisional.	3.14777e-154
NZ_CP018151.1\|WP_072591485.1\|2279069_2279744_-\|(d)CMP-kinase	gnl\|CDD\|236546	PRK09518, PRK09518, bifunctional cytidylate kinase/GTPase Der; Reviewed.	2.89165e-68
NZ_CP018151.1\|WP_072591487.1\|2284235_2285138_-\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|234713	PRK00283, xerD, tyrosine recombinase.	1.41038e-145
NZ_CP018151.1\|WP_072591479.1\|2272465_2273050_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	9.50132e-07
NZ_CP018151.1\|WP_072591482.1\|2274428_2274815_+\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	3.55475e-21
NZ_CP018151.1\|WP_053096852.1\|2285733_2287452_-\|CTP-synthase	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NZ_CP018151.1\|WP_053096842.1\|2277556_2279077_-\|ribosome-biogenesis-GTPase-Der	gnl\|CDD\|179525	PRK03003, PRK03003, GTP-binding protein Der; Reviewed.	0
NZ_CP018151.1\|WP_072591490.1\|2291102_2292140_-\|HAD-IIA-family-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	6.97245e-76
NZ_CP018151.1\|WP_083569352.1\|2279736_2280882_-\|prephenate-dehydrogenase	gnl\|CDD\|235824	PRK06545, PRK06545, prephenate dehydrogenase; Validated.	1.10087e-117
NZ_CP018151.1\|WP_072591484.1\|2276509_2277448_-\|NUDIX-hydrolase	gnl\|CDD\|366006	pfam00293, NUDIX, NUDIX domain.	9.96937e-12
NZ_CP018151.1\|WP_072591481.1\|2273760_2274429_+\|hypothetical-protein	gnl\|CDD\|377946	pfam07947, YhhN, YhhN family. The members of this family are similar to the hypothetical protein yhhN expressed by E. coli. Many are annotated as possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues. A human member of this family, formerly known as TMEM86B, is a lysoplasmalogenase that catalyzes the hydrolysis of the vinyl ether bond of lysoplasmalogen. Putative conserved active site residues have been proposed for the YhhN family.	3.27665e-13
NZ_CP018151.1\|WP_053099169.1\|2283245_2284079_-\|ParA-family-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	2.12437e-84
NZ_CP018151.1\|WP_072592317.1\|2282335_2283154_-\|segregation/condensation-protein-A	gnl\|CDD\|224273	COG1354, scpA, Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair].	4.56281e-44
NZ_CP018151.1\|WP_072591489.1\|2290068_2290866_-\|TlyA-family-RNA-methyltransferase	gnl\|CDD\|224110	COG1189, COG1189, Predicted rRNA methylase [Translation, ribosomal structure and biogenesis].	2.55665e-90
NZ_CP018151.1\|WP_053099170.1\|2285140_2285719_-\|NUDIX-hydrolase	gnl\|CDD\|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	2.91658e-44
NZ_CP018151.1\|WP_072591488.1\|2287469_2289161_-\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	1.30263e-157

>NZ_CP018151.1|WP_083569352.1|2279736_2280882_-|prephenate-dehydrogenase
MTDTTSAPTGARSSVAPRIAARLSGTVRVVGAGLLGASIGHALRAKGVDVVLADTSPAQLRLAIDYGAGRSAAEDDSPVLVVVAVPPDVTADVIESELSRFPHAVVTDVASVKLEPLHSLQHRGVDLTRYIGSHPLAGRERGGAISARADLFVGRPWVVCRDADTTATDLALVEALALDVGAMPLEMTPEEHDRSVALTSHVPQVVASLLAGRLATADEGALRLSGQGVRDTTRIAASAPELWVQILGANAGPVVEILDALASDLREVSDALRAPEAPGARRVVAETIRQGNDGVERLPGKHGQNQRFESLVVMVDDTAGQLGRLFGELGELGVNVEDLRLEHSPGAQFGLAEISVDPAALHGAITGLQERGWRIAGTTND
>NZ_CP018151.1|WP_072591485.1|2279069_2279744_-|(d)CMP-kinase
MTDFIAIDGPAGSGKSSVSKAVARALGFGYLDTGSAYRALAWHVLDRGADTADAAAVLDAVSHFPVRLGLDPDDRTVLVGEVDVTDAIREPSVSSAVSGVARVPEVRDRVNRLFRTLVAEAPYPAVVVEGRDITTVVAPDAPVRILLTAAPEVRAARRAGELAGENAEAVAAALHKRDASDSAVVDFLNAADGVEVVDSTELDFTQTIDAVLAVIERIRGVHHG
>NZ_CP018151.1|WP_053096842.1|2277556_2279077_-|ribosome-biogenesis-GTPase-Der
MADDEYEGGPDQLAEKMESLDEQLAEARAETLRAGLADYDLDDEDAALLAGITMGEDGIQFFPALPVVAIVGRPNVGKSALVNRILGRREAVVEDTPGVTRDRVTYKAEWADRRFSLVDTGGWEPDARGIDRSVAAQAEVAIDLADIVLFVVDAMVGATSTDEHVVKLLRKSGKPVFLVANKIDDARQEPEAAALWNLGLGEPYPVSAIHGRGVADLLDQLLKKLPDVSAVAKAEIGGPRRVAILGRPNVGKSSLLNKAAGEERVVVNDLAGTTRDPVDEIVELGGKLWRLVDTAGIRRRVHMAQGADFYASLRTSAALEKAEVAVVVLDVSETISEQDVRIIDLVLESGRSLVLAFNKWDRLNDDDLENADRRRYLEREIEQDLAHVAWAPRVNISAKTGRHLDKLVPALETALENWDRRIPTGKFNAFLAELVAEHPHPLRGGKQPRILFGTQASTRPPTFVLFTTGFLDPGYRRFIQRRLRELYEFDGTPIVINMRVREKRQR
>NZ_CP018151.1|WP_072591484.1|2276509_2277448_-|NUDIX-hydrolase
MTVVPPAAGEPRRPDGPRNPGDAWVIAPSGEKYWGRFGAAGLLAVDPERGILLQHRVSWSHFGGTWGLPGGAMHEGESAIVGAVREAQEEAGVPDAAVRPRFTSVLDLDVWSYTTVIADVVRPFDPVISDPESVALEWVPVDEVDARPLHPGFGSAWPALRTLLDVRLSLVVDAANVVGSVPNGWWRDRAGATARLASRLDGLAVPAADLGVGGATWFPEIALVVEGQARGIVTPSSDADAEVPELLPAGGVSIVRAEGAGDEAIVAEVERRTRAGQHVVVISSDRELQNRVDVAGAAQVRSAGWLLSVLPQ
>NZ_CP018151.1|WP_072591483.1|2274853_2276308_+|HNH-endonuclease
MTRRTDFDLDLEERCRLLDEWVATRRQIAALEAESYALLVERIGMHDSDVSESPHHREAIYRSMVAEYSAAGHIPKGSVEYAFTDARTLTRTLPAVQAAFSVGSIGERHVREIVRASEIVDDAIRDGRVDAETMSVYEAAVLVVAENDTAPRTKTHARQVAAALVGETVVEQHRRAAAERCVTVKSVGDGLAALTAILPEWVAVAISDRLTQMARHITRTRNEQEPILEPLDEPEGSLYLDDLSPDDPRYESYFDTAVIAADGTFVTDPLAGLIDPMADPSSPDIEHLSGDARTFDQMRADVLADLLLTADPSEATGTGLENISARIQVTVAASTLAGEDDRPAELDGHGPLDPDVARGLAGHRTGWARLFLDAQGLVTETDSYSPTEQMRRFLRARDQHCRFPGCRMPVHRCEIDHNHDHARGGRTRVDNLSHFCTTHHSLKHPDIHERHRWTARQTSDGSLTWTSPLGREYVDPPRRRVMFV
>NZ_CP018151.1|WP_072591482.1|2274428_2274815_+|RNA-binding-S4-domain-containing-protein
MADAARVDSWLWAIRVYKTRSAATTACRAGHVRMNGDKVKAAQHIRVGDELRIRIAGFDRILIVRQLLVKRVGAPLAALAYEDRTPEREPQAALGLRDRGAGRPTKRERRDIDKLRGRGYEDDGIFQG
>NZ_CP018151.1|WP_072591481.1|2273760_2274429_+|hypothetical-protein
MQRRRRSDPLLWAFLPYAAASAAHVALLSVGSPAAGPTKLLLMPLLAVPVFVSVGRAAERSALALTIAALLFSWLGDSAGVFFPAAPEVPLMLLFFGIAHLAYIALFMRHLAARRMPWWALVYAAWWVVMLVFIGPHAGGLLIAVAVYGLVLASTAAAATRCSALVSIGGAFFLASDTLLALRLFLPGSLPDWSSPAIMATYTLGQGLIIAGTLIALRKRDI
>NZ_CP018151.1|WP_056278988.1|2273264_2273720_+|hypothetical-protein
MSDENPTIEDPELGTLTRATTELSDGTVLTHDWYAGGTVVAAAPLDLMIEGTDAGEAAALLPHVHQTIAALGVLRRLATDAVVAAFSNAAPEQHELDDAATDLTLETLEASSDGTVVLHFIDTCGQHFPEGYWPAVHLGADGQITQVTVES
>NZ_CP018151.1|WP_072591480.1|2273046_2273244_+|hypothetical-protein
MNEETDLPASMGKVARRGLALHGFTRLDQFDDASEAALLAIHGVGPKAIRILREHLESRGSTLGP
>NZ_CP018151.1|WP_072591479.1|2272465_2273050_+|GNAT-family-N-acetyltransferase
MVTITTEVATSARWDDVQHALTGGGDGASCQCIWPMLSNKEWNETTTPQRIEMLHDEIQAGPPPGLIAYIDGEAAGWIRIGPRTLQQRVPRTRMIAAASTEPFDDESVWAVTCFVVRREHRGLGITLELLRAAVDLARRSGAGLVEGYPVDTRGEKKRTNDLFHGTLATFLAAGFEERAEMKPGRTLVALDLSS
>NZ_CP018151.1|WP_072592317.1|2282335_2283154_-|segregation/condensation-protein-A
MGSDIADTAPPADPGFRVSLSNFDGPFDLLLNLISKHEMDITEVSLSAVTNEFIAYLKELDDDEELDQASEFLVVAATLLDMKVAGLLPQGELVDAEAVALLEARDLLFARLLQYRAFKEVSAWFARCLQREDRRHVRAVRLDEKHRRKTPELVWSLSADDFAALALLAFAPKEIPHVGLDHLHAPLVSIREQAAIVVTLLRAAESVSFRELVAGVSEPGIVVARFISVLELYRHAALSFEQLEPLGELTLRWAADSWSDETLASLGADYDR
>NZ_CP018151.1|WP_053099169.1|2283245_2284079_-|ParA-family-protein
MGPTGRPYHGFATPAPLASHGPARIIALCNQKGGVGKTTTSINLAAALAEYGRKVLAVDFDPQGALSAGLGIQTHDVPTIYDLLLDTKRDAHDAIVHSGVEGLDVMPANIDLSAAEVHLVNEVARETILARVLRQVAGEYDVILIDCQPSLGLLTVNALTAAHGVIIPLECEFFALRGVALLIETIDKVRDRLNPSITMDGLLATMYDPRTLHSREVLERVVEAFGDDVLETVIGRTVKFPDASVSGVPITEFAPEHAAAQAYLRLARELVARGAVA
>NZ_CP018151.1|WP_072591487.1|2284235_2285138_-|site-specific-tyrosine-recombinase-XerD
MQLDRALDTYLRHVTIERGLSEHTISAYRRDLDMYLEWLVSEGVTDTAEISPAVVGRFIADRSGADPAPAATSLARLQSSVRGWHRFLAREGIEPDDPSGRLRPPKAPRRLPKALTIDQVESLLGAPSAEDPLGIRDRALLELLYATGARVSEAVGLDVDDLAHGDVLRLRGKGSKERIVPIGSFARAAVDAYLTRVRPGLAVKGRASARLFLGARGAPLSRQSAWLVIRAAAENAHITAEVSPHTLRHSFATHLLQGGADVRVVQELLGHASVATTQIYTHVSVDTLRDIYATSHPRAR
>NZ_CP018151.1|WP_053099170.1|2285140_2285719_-|NUDIX-hydrolase
MSEFDELRDEPFQPEVLQSDLVYEGAVWNVRDDRVRYGDGEIRRQYVAHTGAVAILALDDQGRVLLIQQYRHPIRHRDWELPAGLLDMPGEEPLAAAQRELAEEADLVAAHWEPLVSSWTTPGGNDEVIHVFLASGVSTANEAHARVDEEADIRVEWVPLDAAVAAVLDGRMRNGILSIGVLAAAQRLRDRS
>NZ_CP018151.1|WP_053096852.1|2285733_2287452_-|CTP-synthase
MNSSSAGPKNDTTKHIFVTGGVVSSLGKGLTAASLGNLLTARGLRVVMQKLDPYLNVDPGTMNPFQHGEVFVTDDGAETDLDIGHYERFLDINLSQAANVTTGQIYSQVIARERRGEYLGDTVQVIPHITDEIKRRMRLQATEDPRPDVIITEVGGTVGDIESQPFLEAARQLRHELGRDSVFFVHVSLVPFMGASGEQKTKPTQHSVAALRQVGIQPDALVLRSDRPVSESNRNKIALMCDVDAEGVINTVDLPSIYDIPSTLNDQGLDSYIVRRLGLDQKAADEVDWSRWSKVLHAVHNPKHEVTIGLVGKYIDLPDAYLSVTEALKAGGFAQETKVNIRWIPSDRCETPEGAREQLAALDGICVPGGFGIRGIEGKLGALKFAREQGIPTLGLCLGLQCMVIEYARDVAGIEGASSSEFDPETTEPVIATMAEQIEILDGGDLGGTMRLGLYKAALAEGSLASELYGGPEASERHRHRYEVNNAYRARLSEAGLVFSGLNPELDLVEYVELPRDVHPYYIATQAHPELRSRPTDPHPLFRGLVGAAIERHRSSELFDVEADAEFGEAVA
>NZ_CP018151.1|WP_072591488.1|2287469_2289161_-|DNA-repair-protein-RecN
MIEEMRMQGLGVIADAVLPLGPGFTAITGETGAGKTMVVTGLGLLLGQRADSGAVRAGATQASVAGVWIVPETGDVADIVADAGGELEPAGSGAAELYVSRTLSAEGRSRASVGGRAAPAGVLSALAEELVVVHGQSEQLRLRSAAAQRDALDRFGGAPIARALDAYASSFTRWRELDSEIADITENRDRRADEASRLREALALIEAAAPEPGEDVELSARAERLANAEELRLAASLAHGALSNEEGEPDASALIAEARRALERVSDAALTEISAGLADIGYRIADIAGQLSAYLADLDESGPHELAAVEERRAALSTLIRAHGSLDETLELWQTGSTRLAELEDDGERLARLEAERDAARAELDSRAEALTAERTAAAARLGVAVSDELHELAMPDATLEVAVTPGAESAHGRDDVAILLAPHPGAEPRSVSKGASGGELSRVMLAIEVVIAGTDPVPTFVFDEVDAGIGGAAAIEVGRRLARLAEKSQVIAVTHLAQVAAFANNHLSVVKSHDGAVTASSVRRLEGQEREAEMARLLSGLTDSDAAITHARELLSLGALTS
>NZ_CP018151.1|WP_053096854.1|2289157_2290072_-|NAD-kinase
MNERNILVVAHAGREDTVEAALRVVDALRGAGARPVLAADDSLDLRAVDARFADVDVLGETVQQEQLELAIVLGGDGTILRAAELVRGCAAPVLGINMGHVGFLAEIDRDDMDAAMRRVIDRDYEVEERLALSVRVKDVDGEVVYETFALNEATVEKASRERMIEVVLEIDGRPLSSFGCDGMVVSTPTGSTAYNFSAGGPVIWPSVEAIAVVPLSAHALFAKPLVVSPDAAVAIEMLEGTSGAGILWCDGRRSHDLPPGARVVVRRSSRPVRLARLHPTAFTDRLVRKFQLPVAGWRGQGAAS
>NZ_CP018151.1|WP_072591489.1|2290068_2290866_-|TlyA-family-RNA-methyltransferase
MTRLDAALAARGLARSRTHAATLIADGLVSVDGRPVVKASTPVSDEAEISVAGADHYVGRGAHKLVAALAGFGISAEGRLALDMGASTGGFTQVLRERGARRVLAVDVGHDQMAAAVASDPGVVRVEGYNVRYMTPENLRDVTGEDAAPDLIVGDLSFISLEHVLPAVASVAAAGSDIVLLVKPQFEVGRTAVRGGLVTDPATRADAVARTAWSAWDAGLGMLGILSSPILGTHGNTEYLLHLAPGRGSDPSEWSDRINELTGRR
>NZ_CP018151.1|WP_072591490.1|2291102_2292140_-|HAD-IIA-family-hydrolase
MGLFSKKPALRTPLDGVDAVLADLDGVVYAGPGALPYAVESLNAAGETARLGYITNNASRTDASVAEHLSSLGLDVAPADVITSPQAAMRLLAGIVPPPATLLIVGGAGLVDEAEKAGYTVTRSAEDAPDAVVQGFAPEVAWTDLAEAAFALKLPEDEGGIPWIATNTDWTIPRERGVAPGNGTLVSAVHTAIGRLATVAGKPETPIFEEATSRFGATKPLFIGDRLDTDILGAVRAGIDSALVLTGIDRPKHVLAAPEGSRPTYILSDLRELHQPYPELTSKDGVYSVNGASVRVSGADVEIIAEGEAQIDLLRAGAAAIWASGTPVFVLRVPERLYDDPFHRP
>NZ_CP018151.1|WP_072591491.1|2292139_2293009_-|hypothetical-protein
MASRLIDEDPALAHEHALAASRRAGRIAIVRETLGITAYATEDFALALRELRTYRRISGKDDQIALMVDSERGIGRPDRALETGRAVDRTALTTPVRVSLAIAMSGARLDQGDLELALGELEIPELDPDRAFEWSPALFAARAAVLEDLGRTDEAEFWAHRAEVAAEALGVDEAGDEEIIIEDGLIEGDFDDDHAEDGRSDSESDDSESDDSESDDSGSDDSESDLEPAESDETIAAAGAEEADTESDIESEPSIDDEVRELLGEDEDEDGDLADTDAKRTASEPSEEA

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Crispr_ID: NZ_CP018151_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018151_3

3213940-3214134

Orphan

Consensus_repeat	Method
GCGTGCGTCCGTGAGGTGCG	CRT

3 spacers

The CRISPR arrays of NZ_CP018151_3

>merge|NZ_CP018151|3|3213940-3214134|CRT
CGGTCCGTCCGTGAGTCGTGCGTCCGTGAGGTGCGTGCGTCCGTGAGGTGCGTGCGTGAGGTGCGTGCGTCCGTGAGGTGCGTGCGTCCGTGAAGTACGGCATCCGTGAGTCGCGTGCGTCCGTGAGGTGCGTGCGTGAGGCGCGGCATCCGCGAGACGCGTGCACCCGCGAGACGCGCGCGTCCGTGAGGTGCG

>NZ_CP018151|3|1|3213940-3214134|CRT
CGGTCCGTCCGTGAGTCGTG	CGTCCGTGAGGTGCGTGCGTCCGTGAGGTGCGTGCGTGAGGT
GCGTGCGTCCGTGAGGTGCG	TGCGTCCGTGAAGTACGGCATCCGTGAGTC
GCGTGCGTCCGTGAGGTGCG	TGCGTGAGGCGCGGCATCCGCGAGACGCGTGCACCCGCGAGAC
GCGCGCGTCCGTGAGGTGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018151.1\|WP_072591953.1\|3211771_3212956_-\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_CP018151.1\|WP_072591957.1\|3218855_3220457_-\|ATPase	unknown	unknown	gnl\|CDD\|198356
NZ_CP018151.1\|WP_082297901.1\|3197500_3198061_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176862
NZ_CP018151.1\|WP_072591954.1\|3214330_3215230_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP018151.1\|WP_072591960.1\|3222488_3223334_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223528
NZ_CP018151.1\|WP_072591956.1\|3217283_3218807_-\|L-arabinose-isomerase	unknown	unknown	gnl\|CDD\|179503
NZ_CP018151.1\|WP_072591952.1\|3201550_3203053_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143404
NZ_CP018151.1\|WP_083569396.1\|3205331_3211364_-\|pullulanase-type-alpha-1,6-glucosidase	unknown	unknown	gnl\|CDD\|273974
NZ_CP018151.1\|WP_053097861.1\|3213305_3213893_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|225765
NZ_CP018151.1\|WP_072591950.1\|3199443_3200346_-\|3-hydroxyisobutyrate-dehydrogenase	unknown	unknown	gnl\|CDD\|130753
NZ_CP018151.1\|WP_053097877.1\|3224587_3225610_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP018151.1\|WP_072591962.1\|3225802_3227101_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP018151.1\|WP_072591958.1\|3220453_3221173_-\|L-ribulose-5-phosphate-4-epimerase	unknown	unknown	gnl\|CDD\|235829
NZ_CP018151.1\|WP_072591951.1\|3200342_3201524_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173851
NZ_CP018151.1\|WP_072591959.1\|3221417_3222431_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380488
NZ_CP018151.1\|WP_053097849.1\|3198622_3199399_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|180295
NZ_CP018151.1\|WP_053097846.1\|3198057_3198501_+\|DUF1905-domain-containing-protein	unknown	unknown	gnl\|CDD\|379149
NZ_CP018151.1\|WP_072591955.1\|3216354_3217284_-\|aldose-1-epimerase-family-protein	unknown	unknown	gnl\|CDD\|185699
NZ_CP018151.1\|WP_083569395.1\|3203222_3205262_+\|beta-galactosidase	unknown	unknown	gnl\|CDD\|367090
NZ_CP018151.1\|WP_072591961.1\|3223864_3224539_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP018151.1\|WP_072591953.1\|3211771_3212956_-\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	3.51609e-164
NZ_CP018151.1\|WP_072591957.1\|3218855_3220457_-\|ATPase	gnl\|CDD\|198356	cd07778, FGGY_L-RBK_like, L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is composed of a group of putative bacterial L-ribulokinases (RBK; EC 2.7.1.16) and similar proteins. L-RBK catalyzes the MgATP-dependent phosphorylation of a variety of sugar substrates. Members of this subfamily belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.	0
NZ_CP018151.1\|WP_082297901.1\|3197500_3198061_+\|SRPBCC-family-protein	gnl\|CDD\|176862	cd07820, SRPBCC_3, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	5.42972e-43
NZ_CP018151.1\|WP_072591954.1\|3214330_3215230_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	6.32096e-29
NZ_CP018151.1\|WP_072591960.1\|3222488_3223334_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	6.38326e-39
NZ_CP018151.1\|WP_072591956.1\|3217283_3218807_-\|L-arabinose-isomerase	gnl\|CDD\|179503	PRK02929, PRK02929, L-arabinose isomerase; Provisional.	0
NZ_CP018151.1\|WP_072591952.1\|3201550_3203053_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	gnl\|CDD\|143404	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2. Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.	0
NZ_CP018151.1\|WP_083569396.1\|3205331_3211364_-\|pullulanase-type-alpha-1,6-glucosidase	gnl\|CDD\|273974	TIGR02103, pullulanase-like_protein_starch, alpha-1,6-glucosidases, pullulanase-type. Members of this protein family include secreted (or membrane-anchored) pullulanases of Gram-negative bacteria and pullulanase-type starch debranching enzymes of plants. Both enzymes hydrolyze alpha-1,6 glycosidic linkages. Pullulan is an unusual, industrially important polysaccharide in which short alpha-1,4 chains (maltotriose) are connected in alpha-1,6 linkages. Enzymes that cleave alpha-1,6 linkages in pullulan and release maltotriose are called pullulanases although pullulan itself may not be the natural substrate. This family is closely homologous to, but architecturally different from, the Gram-positive pullulanases of Gram-positive bacteria (TIGR02102). [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP018151.1\|WP_053097861.1\|3213305_3213893_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|225765	COG3224, COG3224, Uncharacterized protein conserved in bacteria [Function unknown].	8.97197e-39
NZ_CP018151.1\|WP_072591950.1\|3199443_3200346_-\|3-hydroxyisobutyrate-dehydrogenase	gnl\|CDD\|130753	TIGR01692, 3-hydroxyisobutyrate_dehydrogenase_mitochondrial, 3-hydroxyisobutyrate dehydrogenase. 3-hydroxyisobutyrate dehydrogenase is an enzyme that catalyzes the NAD+-dependent oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde of the valine catabolism pathway. In Pseudomonas aeruginosa, 3-hydroxyisobutyrate dehydrogenase (mmsB) is co-induced with methylmalonate-semialdehyde dehydrogenase (mmsA) when grown on medium containing valine as the sole carbon source. The positive transcriptional regulator of this operon (mmsR) is located upstream of these genes and has been identified as a member of the XylS/AraC family of transcriptional regulators. 3-hydroxyisobutyrate dehydrogenase shares high sequence homology to the characterized 3-hydroxyisobutyrate dehydrogenase from rat liver with conservation of proposed NAD+ binding residues at the N-terminus (G-8,10,13,24 and D-31). This enzyme belongs to the 3-hydroxyacid dehydrogenase family, sharing a common evolutionary origin and enzymatic mechanism with 6-phosphogluconate. HIBADH exhibits sequence similarity to the NAD binding domain of 6-phosphogluconate dehydrogenase above trusted (pfam03446). [Energy metabolism, Amino acids and amines].	5.51248e-114
NZ_CP018151.1\|WP_072591962.1\|3225802_3227101_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.55855e-61
NZ_CP018151.1\|WP_072591958.1\|3220453_3221173_-\|L-ribulose-5-phosphate-4-epimerase	gnl\|CDD\|235829	PRK06557, PRK06557, L-ribulose-5-phosphate 4-epimerase; Validated.	1.88804e-146
NZ_CP018151.1\|WP_072591951.1\|3200342_3201524_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173851	cd01162, IBD, Isobutyryl-CoA dehydrogenase. Isobutyryl-CoA dehydrogenase (IBD) catalyzes the alpha, beta- dehydrogenation of short branched chain acyl-CoA intermediates in valine catabolism. It is predicted to be a homotetramer.	0
NZ_CP018151.1\|WP_072591959.1\|3221417_3222431_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380488	cd01574, PBP1_LacI, ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of LacI is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	6.05777e-89
NZ_CP018151.1\|WP_053097849.1\|3198622_3199399_-\|enoyl-CoA-hydratase	gnl\|CDD\|180295	PRK05862, PRK05862, enoyl-CoA hydratase; Provisional.	2.52601e-138
NZ_CP018151.1\|WP_053097846.1\|3198057_3198501_+\|DUF1905-domain-containing-protein	gnl\|CDD\|379149	pfam13376, OmdA, Bacteriocin-protection, YdeI or OmpD-Associated. This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S). YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein.	2.129e-16
NZ_CP018151.1\|WP_072591955.1\|3216354_3217284_-\|aldose-1-epimerase-family-protein	gnl\|CDD\|185699	cd09022, Aldose_epim_Ec_YihR, Aldose 1-epimerase, similar to Escherichia coli YihR. Proteins similar to Escherichia coli YihR are uncharacterized members of aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism, catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen.	2.44081e-124
NZ_CP018151.1\|WP_083569395.1\|3203222_3205262_+\|beta-galactosidase	gnl\|CDD\|367090	pfam02449, Glyco_hydro_42, Beta-galactosidase. This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.	0
NZ_CP018151.1\|WP_053097877.1\|3224587_3225610_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.13952e-96

>NZ_CP018151.1|WP_053097861.1|3213305_3213893_+|antibiotic-biosynthesis-monooxygenase
MSSEPITVSIRREVDPEHVAAATAWVQTGVNLAHRYPGFLGSGWVRDGEDSHVWHMLYRFSDEKSLVAWEQSGEREWWKSTGEQFVRSERVRRRTGIEGWFDEPTTDTITLPRADGSTTTVAMVSTPPRWKQAVSIWLGFFPLNLAFTYALSPVPGWNELPIWLRVLATTVVLTPIMTYWVLPWVTRTLRHWLNR
>NZ_CP018151.1|WP_072591953.1|3211771_3212956_-|thiolase-family-protein
MSTRSEAVLIDVVRTPVGRGKPGGALSGVHPVDLAAGALAAILERSGLESRQIDDVLLGCVSQVGDQSSNIARQAVLAAGFDESIPATTIDRQCGSSQQAVHFAAQGIMAGAYDAVIVGGVESMSRVPLGSSASGGSPMSPRLRERYPEGLVNQGVSAELIAQRWGIDRAALDEYAAESHRRAAAAWHEGFFDRTVIPVAEAPDAAGDETVRAGTTAEGLGGLSPAFRTDALAARFPDVDWRITPGNSSPLTDGASAALVMSAERAEQLGLTPRARFQAFTVVGDDPLMMLTGPIPATRRILERTGLTIDDLDAYEVNEAFASVPLAWAAELGADAAKLNPRGGAIALGHALGSSGTRLLGTLIDHLDAVGGRFGLQTMCEGGAMANATIIERL
>NZ_CP018151.1|WP_083569396.1|3205331_3211364_-|pullulanase-type-alpha-1,6-glucosidase
MFKSARSKTTASRPLALLAATALVVSGFGAAGTLGGSSAAAADRTVALVGSLQSELGCAADWAPDCTGTELQPTGAEGIYSAEFEVPAGTWQYKVAVNDSWDEAYGLDGGADDIPLTVAGPTTLRFTFDDTLKRVGLEAADLRGGYTSDDEALIASPARQAGAGEQFYFVMTDRFANGDTANDTGGLEGDRLTTGFDPTDKGFYQGGDIAGIRENLDYIEGLGTSAIWLTPSFANKPVQGEGANASAGYHGYWITDFTRIDPHLGTNEELQALIADAHARDIKVYFDIITNHTADVIDYAEGQYSYIDQATSPYTDAAGTAFDPADHAGTDGFPELDLATSFPYTPVIDDSEADVKVPAWLNDPSLYHNRGDSTWSGESVTYGDFSGLDDLMTEHPTVVNGFVEVYDKWIDLGIDGFRIDTVKHVNFEFWEKWTADVLDYAHEKGNDDFFMFGEVYDADPVKLAPYVRDTDMNSILDFTFQSSAVSYASGNSAKGLQSLFAGDDRYTTPDSSATALPTFLGNHDMGRVGSFLQTTDAPLERDELAHELMFLTRGQPVVYYGDEQGFTGPGGDKDARQSLFATQVDDYANQNLITGEQAGSVDRYATDAALYEHIAALSELRESNPALSEGAQIERYAASGAGVYAFSRVDADDKVEYLVAVNNAATAQTVDLTTLTADASYEVLYGDAASLATDAGAAASITVPALSAVVWKADSTVTAPSEAASVEVVVPAAGAGVTGQSAVQADIADQWAQTSFAWRVVGSEEWQALGTAEDTDPRVFHDIRDLANGTLVEYRAVTTDAAGNHAAASTYASVGNAVTLTAGEEPESPIDMVTVPGSLNSEMGCAGDWDPACEKAKLTLRADGVWEGAFDLPAGDYEYKAAINGSWAVNYGANGVPDGSNVTLTHAGGPITFYFDPRTNIVQSSADGPIVTLPGSLQDELGCAADWSPDCLGTLMADGDRDGVYEFSTADLPTGAYELKVAHGLSWAENYGADGVPGGANISFSAAEGSVTSFRYTLATHVLEVVSADPQLPGAGEQRAQWVDAETIAWPAALGSVDKAAYQLYSSADASLAVADGDIAGGESIALEVIEGGLTDEQLARFPALDGYLALRVTDADAAALLRSQLAVVQRDETGAPSAFTGVQIAGVLDDLYAAALDDVDLGVTFSGKKPTFRLWAPTAQSATLLTWDEGAEGDPARHEATWDAASGVWSVAGAKDLKGDEFLWEVVVYAPTTGAIETNRVTDPYSTALTLNSRRSVAIDLDDKAWQPKQWQKAEAPVVERAVDRAIYELHIRDFSISDETVPADERGTYLAFTRDSAGTDQLKQLADAGINTVHLLPSFDIASIEEDRAAQAVPDCDLASFGPADAAQQACIQAVADADGFNWGYDPYHYSTPEGSYAVDADGGARVSEFRSMVGALHDMDLQVVLDEVFNHTAASGQAEKSVLDQVVPGYYHRLNAAGGVETSTCCQNVATEHLAAQKLMVDSIVTWARDYKVDGFRFDLMGHHSTTNMQAIRDALDALTLAKDGVDGSAIHLYGEGWNFGEVADDALFEQATQGQLGGTGIGTFNDRLRDAVHGGSPVDSSSTFRQGFGTGLGTDPNGDPINGTVEQALADLGHEADLVKLGLAGNLRDFEFTTSDGSVTAGEAIDYRGSAAGYADQPDETINYVDAHDNETLYDLSVLKLPVDTTMADRVRMNTLELATVTLSQSPSFWHAGTELLRSKSLDRNSYNSGDWFNRIDWTGQESTFGSGLPTAADNEEKWPIMAPLLADPALKPAAADMAAAEASALDLLRIRDEVDLLRLGSAELIQQKVTFPNGGAGAAPGVILMQIDDLTGPDADADLDGALVAFNSSPAPVTQTVAGLAGRSFALTPAQANGADAVVKTTTWDAATGTVTIPARSVAVLVDDQMQPIDTRVRASSDLLVKSGKSATVKVTVAADDDSAAVGTVTVHDRGKVVATVELAPSDKGRVTVSVPKLSRGVHLLTVRFDGTEPWQDSRSTRSLPVIVY
>NZ_CP018151.1|WP_083569395.1|3203222_3205262_+|beta-galactosidase
MHYGADYNPEQWPREVWPDDVRLMREAGVTLVSLGIFSWSRIQPAEGEFDWEWLDEIIGLLHEGGIQVDLATATASPPPWASTAYPEMLPQDADGSTFWPGSRQAFAPSSPVYRRLAAELVTALAERYAQHPAVVLWHVNNEYGCHLHYDYSDAARDAFRAWLQRRYATIDALNHAWGTDFWSQRYTAFDQIVPPRKAPYSINPTSVLDFKRFTSDTLLELYVMERDIIRAAGATQPITTNFMGAFPPADYWKWAAEVDVISDDNYPDPNDPESFRGAAFARELMRGLKPGVPWILTEQSTNALNWRPTNAPKAPGQMAAISAQAVGRGADGIMFFQWRQSRRGSEKFHSAMVPQAGLDTRTWREVVELGGQLAQLPEMPDVSSGAKIALVFDWENWWAIDGRDHPIVLDYLTLSHRWHAALHRQNLAVDIVNTTSDLRGYSLVVAPQQYLLSDEGAANLTAYVAQGGNLFVSAFSDVVDQDDAFREGGFIVSLRDALGVALEDFGALVPPESVRSADSAGEVASHAVPDGPGQSEAPVDGPAGTIVGQYFAEELLVQDAEVLGRFTEGRTAGRAAFTRKPFGDGNGYYLATIPDDAGMAAVLRWLAAEAGVTAEIEGLPEHVEIARRGGILTVINHSAEPFAVDVPGRDVLTGSTAARRELGAYGWAFIDTSGVDARD
>NZ_CP018151.1|WP_072591952.1|3201550_3203053_-|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase
MTRTIPHFVGGKHLTPEGGRFADVFDPSTGSVQARVPLASAHEVADVIANAEAAQVEWAATNPQKRARVLLRFLDLVQREMTELAELLASEHGKTVDDAKGDIQRGLEVIEFSAGAPHLLKGEYSTGAGAGIDVYSMRQPLGVVAAITPFNFPAMIPLWKAGPALAAGNAVVLKPSERDPSVPVRIAELFLEAGLPAGVLNVVHGDKEAVDALLTDDRIRAVGFVGSTPIAEYIYSTAAAHGKRAQCFGGAKNHMIVMPDADLDQAVDALIGSGYGSAGERCMAISVAVPVGQETADALAAKLTQRVAQLRIGPSLASDVDYGPLVTRAAVERVEGYIQQGVDEGATLLADGRGFTVPGHEQGFYLGPTLFDDVTTNMAIYREEIFGPVLVIARAADYEEALRMASEHEYGNGVAIFTRDGDAARDFAARVEVGMVGVNVPIPVPIAYYTFGGWKRSGFGDLNQHGADAFRFYTKTKTVTSRWPSAGIRDGASFVIPTMH
>NZ_CP018151.1|WP_072591951.1|3200342_3201524_-|acyl-CoA-dehydrogenase
MTMTTVTTTAEEREAILDAVREFAETELAPFSAERDEKHIFPRESLGKAGELGLGGIYVSEEFGGTGLSRSDTVAIFEELAKGDPAVAAYISIHNMVVWMIDTYGDDAQRGRWLPDLTAMQEFGGYCLTEPGVGSDAANVATSAVRDGDDYLLTGVKQFISGAGEAAVYVVMARTGEPGARGISAFLVPGDAEGLSFGAPEKKMGWHAQPTRQVILDGVRIPASGMLGDEGRGFAIAMSALNGGRLNIAACSIGGAQWALDRAVQYVHERVAFGEPLAEKQSILFAIADMRTDLQAARLMVTDGALAVDEHAPDATMRCAMAKRFATDAGFDVANRALQLHGGYGYLQDYGIEKVVRDLRVHQILEGTNEIMRLIVGREMLRPAGSASMRSAS
>NZ_CP018151.1|WP_072591950.1|3199443_3200346_-|3-hydroxyisobutyrate-dehydrogenase
MSESSSVRIAFLGLGHMGLPMAKNLVAAGHEVHGFDLVPAAIEAAQAAGIPVAASGADAVADADVVITMFPAGRHVIDAYRTELLAAARPGTLFIESSTIAVDEARAAHALALAAGHRNVDAPVSGGVVGAENGTLAFMVGGSDEDFAAALPVLEIMGTRIVHCGGPGLGQAAKVCNNMVLAVSQIAVAEAFVLGERLGLEHQALFDVVSQASGQCWSITTNCPVPGPVPTSPANRDYQPGFAGALMAKDLGLALQAIEQTSTDARMGRLAQQLYAAFAAGDGATRDFSGIITDIRDGSV
>NZ_CP018151.1|WP_053097849.1|3198622_3199399_-|enoyl-CoA-hydratase
MTEYETILVEQRGRVGWITLNRPEALNALNSRLADEVTAAAVAFDLDDGVGAIVVTGSEKAFAAGADIKEMEGMSASEMLETDHFGVWHEFAAVRTPVIAAVSGFALGGGCELAMMCDIILAADTAKFGQPEINLGVIPGMGGTQRLIRAVGYYKAAELVLSGRFMGAEEAERSGLVSRVVPASDLLAEATRLAETIASKSLPSVFAAKAALDAAMETTLADGLAHEKRAFAELFDTADQKEGMSAFREKRAPDFQNR
>NZ_CP018151.1|WP_053097846.1|3198057_3198501_+|DUF1905-domain-containing-protein
MSELRLHTILEGRGPAAAIILTDEQVASFGAGKAFPVAVTIGGRTARLRLARMGGANMIGFSKAVRTDLGVEIDEEVDAVIRLDAAERTVEVPAALAEALDADTALRAAFDALPYSVRKEHARSVAEAKQDATRERRVAKIVDALRG
>NZ_CP018151.1|WP_082297901.1|3197500_3198061_+|SRPBCC-family-protein
MPPSSSRSSPACARPPATSPTPGRSPSRSDMAAFVLETVIAAPRETVFAVALDPGMHLRSMARYRETMIEAPAGGVFTEGSTVTWRARHFGIPFRLRTIVYDVDPPRGFRDRQLSGPFGAFEHEHVFEEHPQGTLARDTIVFHSPFGPIGRLVDRLILREYMRRLIEERNAHLASEAEGRGRTLPA
>NZ_CP018151.1|WP_072591954.1|3214330_3215230_-|LysR-family-transcriptional-regulator
MSNRNADGLPDLGLWRTFLIAHRSGSVSAAARRLGLAQSSVTTQLQALEASVGEPLFVRHARGIRPTPRADELAARLSGPLDALADALGTHPALEPPLIRLGGAGEFLAAVAAPALASAVAGGLRLAVTTGLADDLLDQLRVGSLDLVISAVRPRGRALPSMPLFDEEFVLVASPSLSIDPSPALSPDALAHVPLLAYDRDVPIVRRYWRHVFGIRLDREPALVFPDLRALAAAAVAGAGVTALPTYLIADELADGRLVDLRPTKDPPINTLYLVRRPGPLSDGVAAVEKALRAAVADL
>NZ_CP018151.1|WP_072591955.1|3216354_3217284_-|aldose-1-epimerase-family-protein
MTGAGRPRSGRQLRITGHGYEAVIASVGASLRLLAFEGRDLVVPFDADEVRPGYRGTTLAPWPNRIVDGRYTFSGAEHQLALTEPARGQALHGLLAWAEFEDRLVLDDRVVLAAVIEPQTGYPFRVEVETEYRIDGDGLQQTVTARNLGADAAPWGTGPHPYLVAGPDGRVDDWTLTLPASEVLTVTDDRLSPVALEGVSAHPQWDFRVARPIADVFIDHAFSGLAREGGVAEVRVVTDAGSGVVMTFDERCPWVQVHTADNPGIDAIHRIGLAVEPMTCPPDAFNSGTDLVVLEPGATHAASWRIAAV
>NZ_CP018151.1|WP_072591956.1|3217283_3218807_-|L-arabinose-isomerase
MPRTPLTTSLDGYEVWFLTGSQHLYGPETLAQVAEQSQEIARILDEAGEVPVTIVWKPVLTDAAAIKRTALEANADDRVIGLIAWMHTFSPAKMWIAGLDALQKPLAHLHTQANVELPWADIDFDFMNLNQAAHGDREFGYIQTRLGVPRKTVVGHASDPRVRQEIATWQRAAAGLAASRSLKLARFGDNMRFVAVTEGDKTEAELRFGVQVNTWGVNDLADAVAAASDSEIDALVAEYEELYEVVPELRRGGDRHQSLRDGAAIEIGLRTFLEEGGFGAFTTSFEDLGALKQLPGLAVQRLMAEGYGFGAEGDWKTAILVRVANVMGAGLPGGASLMEDYTYDMTPGDELILGAHMLEVSPSLTTAKPTLEIHPLGIGGKEDPVRLVFTADPGPAIVVALSDMRDRFRLTANVVENVPPRQSLPKLPVGRAVWKPQPDFTTSAAAWLTAGAAHHTVMSTAVGLEAFRDFAEMAEVELLVIDDATTLPEFQKQVRWNQAYYRLAQGL
>NZ_CP018151.1|WP_072591957.1|3218855_3220457_-|ATPase
MSDTTRTTARDDILAGRTSLGIELGSTRIKACLIGSDATEVLATGSFSWENRLQDGLWTYAINEVWTGLQAAYAGLVADADERHGVRPETFGAIGISAMMHGYLAFDARGELLTPFRTWRNTNTGAAAAELTDLLGVNIPLRWSIAHLHQAVLDGEAHVPQLDFVTTLAGYVHTRLTGERVLGVGDASGMFPIDSATGDYDERMLQAYDALAADRLPAAAKDLLPTVLPAGAAAGTLTAEGAALIDPSGALPPGIPLCPPEGDAGTGMVATNSVSPRTGNVSAGTSIFAMVVLERPLAEVHHELDLVTTPAGDAVAMVHCNNGASELAAWAGLFTRFAAAAGQPLSDDAVFDALFREALDGEADAGGLLAYNHLAGEPIAGLTEGRPLFVRTPDSAFTLANFMRSQLYGVFGTLALGMQVLAAEGVELDRMFAHGGMFRTAGVAQRFLAGALGAPVAVGELASEGGAWGIAVLASYLAHSETASLGEYLERDVFASASLAVADPDPADVAGFTAYLDRYRAGLAIEAAATTAL
>NZ_CP018151.1|WP_072591958.1|3220453_3221173_-|L-ribulose-5-phosphate-4-epimerase
MSNEAPVFSPEIDASIQAVREDVARLHGELVRYDLIVWTGGNVSGRVPGADLFVIKPSGVSYDDLTPENMILCDLDGAVIPGTPGSDRSPSSDTAAHAYVYRHMPDVGGVVHTHSTFAVAWAARGEEIPCVITAMADEFGGPIPVGPFAIIGDDSIGRGIVQTLSGHRSRAVLMQNHGPFTIGVDAKDAVKAAVMVEDVARTVHYAREAGPLIPIPQEAIDSLFNRYQNVYGQNSDARR
>NZ_CP018151.1|WP_072591959.1|3221417_3222431_-|LacI-family-DNA-binding-transcriptional-regulator
MSDTSSEPRRTVGVRDVAVRAGVSRQTVSRVLNDHPEVAAETRERVLAAMTELGYRMNNAARALGTRRSRTLGVLATDALHYGPSRSIAALEASAREVGYWLSAAFADAGDTDAVVAAVDHLVMQGVEGIVVVAPHAHTLDALDSVRIGVPVVTLHAADRGARGLSVDQEAGARLAVAALADAGHTRIAHLAGPADWLEAESRAEGFQAELAARGLAAGPVIEGDWTAGSGYAAARAVRDSGVTAVFAANDQMALGLLGGLQEVGLSVPADISVVGFDDTPDAAYYWPKLTTVRQDFSELARRAVAAVLVGSAGAAASDLAPVAPVLVTRDSVAPPR
>NZ_CP018151.1|WP_072591960.1|3222488_3223334_+|NAD(P)-dependent-oxidoreductase
MRIALTGSSGKLGSVVARELRAHGHEVIGMDVSGTRGPDFVQVDLTDYGQVVDAFTAVGDRHDGIDAVVHLGAIPAPGIRSDVATFHNNMPATFNVFWAAVRLGIRRVVYASSETVLGLPFDVPPPYVPVDEDYPARPESVYSLVKTLEEQLARELVRWHPDLSITALRFSNVMNPEDYAEFPDFDADALRRKWNLWGYIDARDGAQAVERALEVAAPGFDNFIIAAADTVMTRPNAELLAEVFPDVPVAREFGPNETLLSIDKARRVLGFDPQHSWRDDA
>NZ_CP018151.1|WP_072591961.1|3223864_3224539_+|hypothetical-protein
MPALALLLTSCATAPGTDPAAASVTQDATQSDAAEMLLSLDISAVSTIVFQNTTDLGHRSAAVVTGTVHRWLAGDKVTTATGTPVGAALLAEVEVIEVTENGGSPLQPGDIVYIPVTSPSLDPQEVADALPRDLDVVAYLDDALTDEELQISEEYRVEPGDAEAAGKPRWPLLSPQGFIVTNPSDPGEQLWPFLGARAAGKLTDVLPGGRLDGLTEEQRKLVIG
>NZ_CP018151.1|WP_053097877.1|3224587_3225610_-|LacI-family-transcriptional-regulator
MTDTTGARAATLSDVAARAGVSISTASKALNDRGDVSVATRAKVRAIAEELSFTPNAMARGLLAGRTGTVGLLTSDLEGRFMLPILMGAEDAFGAGRINVFLCDARGDAIREQHHLKELLSRRVDGIIVVGRQTDPRPSLGQEIPVPVVYAYAPSDDPRDLSLTPDNYAGGRLAIEHLLACGRRRIAHISGDPTYAAAQDRLAGARAALGEAGLELVGEPMFSEWTEHWGRDAAAMLLQRHPDIDAVFCGSDQIARGVLDSARDLGRTVPDDLAVIGYDNWEVLATNARPELTSIDANLQQLGRQAALRVFDAIDGIDIGEGAHHLPVRLVIRGSTIARR
>NZ_CP018151.1|WP_072591962.1|3225802_3227101_+|sugar-ABC-transporter-substrate-binding-protein
MNTIRTHAARRAAAAVIAAGLLVGGLAACAPAGDDAASDEPIPAEGTDDGTTLTLWTRAPIERQAKLLVDAYNDSHENQVELTVVPNDDYVAKVGAAAGSSGLPDLFAADIVYVPNWAQQGLFQDMSEQIDALDFKDEINPGHLSAGTVDGAEYVLPFALDLSMLFWNKELFAEAGLDPEKAPATLEEFAEAAMAVQALNKPDTYGTATGLNCGGCLVFTWFPSIWASGDEVMSDDGTESLLDGDSAQAVYDTWAGLEEAGAVLPSSTDEAGPTWTAAFSEGKVGVMPFPATLLPSLEFDAGVAGIPGVDGGASTFVGGDGIGISKDSKKAAQAWNFLNWMMSEDAQVEVLAKDGNAVSRGDLADNEYAAADPRLVTINEVAAQGDTPVALNFQQAFNAPGSPWLTLVRNAVLNGDDSVPADNEEITAILSQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage