CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP018335	Clostridium kluyveri strain JZZ chromosome, complete genome	5 crisprs	WYL,cas3,DEDDh,csa3,cas6,c2c9_V-U4,cas2,cas1,cas4,Cas14u_CAS-V,RT,PD-DExK,cas14j	2	14	20	0
NZ_CP018336	Clostridium kluyveri strain JZZ plasmid unnamed, complete sequence	0 crisprs	NA	0	0	1	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018335_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018335_1

1573776-1573880

Orphan

Consensus_repeat	Method
TTTAAGATTACTAAAAATTTAACAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018335_1

>merge|NZ_CP018335|1|1573776-1573880|CRISPRCasFinder
TTTAAGATTACTAAAAATTTAACAATCCCAGTTAAATTTGGGACAAGGAGGTAGGCTCATGGAGAATAATAACAGTGTATTTAAGATTACTAAAAATTTAACAAT

>NZ_CP018335|1|1|1573776-1573880|CRISPRCasFinder
TTTAAGATTACTAAAAATTTAACAAT	CCCAGTTAAATTTGGGACAAGGAGGTAGGCTCATGGAGAATAATAACAGTGTA
TTTAAGATTACTAAAAATTTAACAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018335.1\|WP_073538312.1\|1575027_1575606_+\|RnfABCDGE-type-electron-transport-complex-subunit-A	unknown	unknown	gnl\|CDD\|227004
NZ_CP018335.1\|WP_073538320.1\|1581780_1582788_+\|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234682
NZ_CP018335.1\|WP_073538309.1\|1571374_1572733_+\|electron-transport-complex-subunit-RsxC	unknown	unknown	gnl\|CDD\|273888
NZ_CP018335.1\|WP_073538319.1\|1581206_1581791_+\|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl\|CDD\|235552
NZ_CP018335.1\|WP_073538304.1\|1565978_1566443_-\|sporulation-protein-YtfJ	unknown	unknown	gnl\|CDD\|131921
NZ_CP018335.1\|WP_073538302.1\|1564514_1565276_+\|segregation/condensation-protein-A	unknown	unknown	gnl\|CDD\|234635
NZ_CP018335.1\|WP_073538311.1\|1574384_1575026_+\|electron-transport-complex-subunit-E	unknown	unknown	gnl\|CDD\|237091
NZ_CP018335.1\|WP_073538307.1\|1568529_1569006_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018335.1\|WP_083585669.1\|1566646_1567201_-\|DUF2953-domain-containing-protein	unknown	unknown	gnl\|CDD\|378578
NZ_CP018335.1\|WP_073538316.1\|1577950_1578418_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276947
NZ_CP018335.1\|WP_156876124.1\|1569118_1570189_-\|chemotaxis-protein	unknown	unknown	gnl\|CDD\|378400
NZ_CP018335.1\|WP_073538317.1\|1578528_1579353_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319818
NZ_CP018335.1\|WP_073538315.1\|1577198_1577855_-\|DUF4397-domain-containing-protein	unknown	unknown	gnl\|CDD\|379570
NZ_CP018335.1\|WP_073538318.1\|1579775_1581206_+\|anthranilate-synthase-component-I	unknown	unknown	gnl\|CDD\|237431
NZ_CP018335.1\|WP_073538314.1\|1576555_1577074_-\|Gx-transporter-family-protein	unknown	unknown	gnl\|CDD\|377839
NZ_CP018335.1\|WP_073538308.1\|1570724_1571138_+\|SoxR-reducing-system-RseC-family-protein	unknown	unknown	gnl\|CDD\|377263
NZ_CP018335.1\|WP_012101651.1\|1572752_1573745_+\|RnfABCDGE-type-electron-transport-complex-subunit-D	unknown	unknown	gnl\|CDD\|376991
NZ_CP018335.1\|WP_073538306.1\|1567336_1568521_+\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224600
NZ_CP018335.1\|WP_073538303.1\|1565259_1565862_+\|segregation/condensation-protein-B	unknown	unknown	gnl\|CDD\|234657
NZ_CP018335.1\|WP_073538313.1\|1575621_1576479_+\|Fe-S-cluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|235941

Protein	Function_ID	Function_description	E-value
NZ_CP018335.1\|WP_073538312.1\|1575027_1575606_+\|RnfABCDGE-type-electron-transport-complex-subunit-A	gnl\|CDD\|227004	COG4657, RnfA, Predicted NADH:ubiquinone oxidoreductase, subunit RnfA [Energy production and conversion].	1.22275e-67
NZ_CP018335.1\|WP_073538320.1\|1581780_1582788_+\|anthranilate-phosphoribosyltransferase	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	0
NZ_CP018335.1\|WP_073538309.1\|1571374_1572733_+\|electron-transport-complex-subunit-RsxC	gnl\|CDD\|273888	TIGR01945, Electron_transport_complex_subunit_C, electron transport complex, RnfABCDGE type, C subunit. The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the C subunit. [Energy metabolism, Electron transport].	0
NZ_CP018335.1\|WP_073538319.1\|1581206_1581791_+\|aminodeoxychorismate/anthranilate-synthase-component-II	gnl\|CDD\|235552	PRK05670, PRK05670, anthranilate synthase component II; Provisional.	5.54899e-107
NZ_CP018335.1\|WP_073538304.1\|1565978_1566443_-\|sporulation-protein-YtfJ	gnl\|CDD\|131921	TIGR02874, conserved_hypothetical_protein, sporulation protein YtfJ. Members of this protein family, exemplified by YtfJ of Bacillus subtilis, are encoded by bacterial genomes if and only if the species is capable of endospore formation. YtfJ was confirmed in spores of Bacillus subtilis; it appears to be expressed in the forespore under control of SigF (see ). [Cellular processes, Sporulation and germination].	5.13785e-61
NZ_CP018335.1\|WP_073538302.1\|1564514_1565276_+\|segregation/condensation-protein-A	gnl\|CDD\|234635	PRK00104, scpA, segregation and condensation protein A; Reviewed.	1.27584e-94
NZ_CP018335.1\|WP_073538311.1\|1574384_1575026_+\|electron-transport-complex-subunit-E	gnl\|CDD\|237091	PRK12405, PRK12405, electron transport complex RsxE subunit; Provisional.	3.87173e-86
NZ_CP018335.1\|WP_073538318.1\|1579775_1581206_+\|anthranilate-synthase-component-I	gnl\|CDD\|237431	PRK13570, PRK13570, anthranilate synthase component I; Provisional.	0
NZ_CP018335.1\|WP_083585669.1\|1566646_1567201_-\|DUF2953-domain-containing-protein	gnl\|CDD\|378578	pfam11167, DUF2953, Protein of unknown function (DUF2953). This family of proteins has no known function.	3.42932e-10
NZ_CP018335.1\|WP_073538316.1\|1577950_1578418_-\|hypothetical-protein	gnl\|CDD\|276947	cd15786, CPF_1278_like, Uncharacterized protein conserved in Clostridia. This protein appears to be a member of a somewhat larger structural family conserved in Firmicutes. The 3D structure is available for one protein, CPF_1278, which has been labelled a putative lipoprotein. CPF_1278 displays structural similarity to the N-terminal domain of YycH, which plays a role in signal transduction and is found immediately downstream of the essential histidine kinase YycG. YycG forms a two-component system together with its cognate response regulator YycF. YycH functions as a modulator of YycG activity, possibly by interacting with YchI. All three molecules (YchG, YchH, and YchI) have been characterized as membrane proteins, and they may be able to form homodimers.	3.76263e-45
NZ_CP018335.1\|WP_156876124.1\|1569118_1570189_-\|chemotaxis-protein	gnl\|CDD\|378400	pfam10114, PocR, Sensory domain found in PocR. PocR, a ligand binding domain, has a novel variant of the PAS-like Fold. Evidence suggests that it binds small hydrocarbon derivatives such as 1,3-propanediol. In (Natural history of sensor domains in bacterial signaling systems by Aravind L, LM Iyer, Anantharaman V, from 'Sensory Mechanisms in Bacteria: Molecular Aspects of Signal Recognition.' Caister Academic Press. 2010) - see (http://de.scribd.com/doc/28576661/Bacterial-Signaling-Chapter).	7.90018e-70
NZ_CP018335.1\|WP_073538317.1\|1578528_1579353_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.89031e-64
NZ_CP018335.1\|WP_073538315.1\|1577198_1577855_-\|DUF4397-domain-containing-protein	gnl\|CDD\|379570	pfam14344, DUF4397, Domain of unknown function (DUF4397). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 120 amino acids in length.	2.23359e-36
NZ_CP018335.1\|WP_073538314.1\|1576555_1577074_-\|Gx-transporter-family-protein	gnl\|CDD\|377839	pfam07456, Hpre_diP_synt_I, Heptaprenyl diphosphate synthase component I. This family contains component I of bacterial heptaprenyl diphosphate synthase (EC:2.5.1.30) (approximately 170 residues long). This is one of the two dissociable subunits that form the enzyme, both of which are required for the catalysis of the biosynthesis of the side chain of menaquinone-7.	9.08434e-46
NZ_CP018335.1\|WP_073538308.1\|1570724_1571138_+\|SoxR-reducing-system-RseC-family-protein	gnl\|CDD\|377263	pfam04246, RseC_MucC, Positive regulator of sigma(E), RseC/MucC. This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions). In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteristic of chronic respiratory tract colonisation in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain pfam02424, which is itself involved in thiamine biosynthesis.	7.13376e-30
NZ_CP018335.1\|WP_012101651.1\|1572752_1573745_+\|RnfABCDGE-type-electron-transport-complex-subunit-D	gnl\|CDD\|376991	pfam03116, NQR2_RnfD_RnfE, NQR2, RnfD, RnfE family. This family of bacterial proteins includes a sodium-translocating NADH-ubiquinone oxidoreductase (i.e. a respiration linked sodium pump). In Vibrio cholerae, it negatively regulates the expression of virulence factors through inhibiting (by an unknown mechanism) the transcription of the transcriptional activator ToxT. The family also includes proteins involved in nitrogen fixation, RnfD and RnfE. The similarity of these proteins to NADH-ubiquinone oxidoreductases was previously noted.	2.17082e-143
NZ_CP018335.1\|WP_073538306.1\|1567336_1568521_+\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224600	COG1686, DacC, D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane].	4.14245e-88
NZ_CP018335.1\|WP_073538303.1\|1565259_1565862_+\|segregation/condensation-protein-B	gnl\|CDD\|234657	PRK00135, scpB, segregation and condensation protein B; Reviewed.	2.92357e-87
NZ_CP018335.1\|WP_073538313.1\|1575621_1576479_+\|Fe-S-cluster-domain-containing-protein	gnl\|CDD\|235941	PRK07118, PRK07118, Fe-S cluster domain-containing protein.	1.6656e-105

>NZ_CP018335.1|WP_012101651.1|1572752_1573745_+|RnfABCDGE-type-electron-transport-complex-subunit-D
MAEAQTKKDIFTVSTSPHIRCDESISKIMWNVNLALAPAAIFAIYNFGIPALKTMVVGILAAVITEYAVQKIRKKPVTIKDGSAFLTGLLLAMCLPPGIPAYMVAIGAFIAIAIAKHSMGGLGYNIFNPAHIGRAALMLSWPVAMTTWTKLTTSVDTVTSATPLGILKLDGYSKLVDTFGGTGALYKALFIGTRNGSIGETSTILLVLGGLYLIYKRYINWQVPVVMIATVGILTWAFGGTSGFFTGDPIFHMMAGGLVFGAFFMATDMVTIPMTVKGQIIFAIGAGALTSLIRLKGGYPEGVCYSILLMNAVTPLIDRFIQPVKFGARK
>NZ_CP018335.1|WP_073538309.1|1571374_1572733_+|electron-transport-complex-subunit-RsxC
MLKSFLGGIHPNDNKKYTANKPIEVAPIPDKVFIPVRQHIGAPTSPIVKKGDEVKKGQLIAKSDAFVSANVHSSISGKVVDVAEYPHPGFGKCLTIVIENDGKDEWIEGIPISRNWQDLSDKDIMSIIREAGIVGMGGATFPSHVKLSPPADKKVEFFILNGAECEPYLTSDYRSMLEYTDRIVSGVKIIMKILKAEQGFVGIEDNKKDAIEVMEKAFQGTGVQVVALPTKYPQGAEKMLIKVLTGREVPSGRLPMDVGAVVQNVGTCIAVSDAVEKGIPLIQRVTTLSGGALKEPKNLLLRIGTTFKYAIDLCGGFKETPVKVVMGGPMMGFAQSNLEVPILKGVSGILSLSESDANTGTETACIRCGRCLNACPMSLNPSMLSILGQNNLYREAKEDYNLLDCVECGSCVYVCPAKRNIVQYVKYLKAENAAQAARDKAEAEKNKEKVAK
>NZ_CP018335.1|WP_073538308.1|1570724_1571138_+|SoxR-reducing-system-RseC-family-protein
MKKESEGIVIETTEDFARVKASRHGDCKNCGACPGDNATVLDAKNPIGAKAGEHVILEMREQNMIRAAFVVYIMPIISIFLGVLVGTWIFNAVGYYEMVFKVAGGIVFFAISLVYIKVFDKATAKNDASKPVIKKVL
>NZ_CP018335.1|WP_156876124.1|1569118_1570189_-|chemotaxis-protein
MSSFRSYANSLESDISSLKIKDIIDIDLLQKFQDNFAESMDIASVTVDMDGNPVTKPSSYTDFCLRLTQSTDVGTRRCAESHKRGGLEATRTGKPYVYTCHAGLIDFAAPILVAGQQIGTILGGQILTSTPEDAIYKKNAKEIGIDENKYLEAVGRVKITTRKNITAAAEVLYIIINALSKIGYEELQLKKTSQVLSDNLNQISAIMEELSASSVNVSNNQHSLNKEIINIKNISTEINSILDSIKSIADETKMLGLNAAIEAARAADMGRGFGVVATEIRKLSENSKNTAMKISDLTKKIEESVDKTVETSNSTLETTEQQTSAIEETNANLQEVISISDKLNNLAISNMDRFKR
>NZ_CP018335.1|WP_073538307.1|1568529_1569006_-|hypothetical-protein
MKISEKAFFKNVCKYCIDKYTISNNGPLMASLINQLCNRIDMDVPAVQGILCLRINDNYSRSFAHCFNVYNGNIIDASIYQYALIYRSIESLFPTYVVQNTPDYIDYRIDNKMSIRHNVKFNEELLENILKNIEDKDLPEIKRFNLNEDSKKENLFYL
>NZ_CP018335.1|WP_073538306.1|1567336_1568521_+|D-alanyl-D-alanine-carboxypeptidase
MKSMGLKKVNIIIFFIIFNNICCYNVFAEGEQGIIKAPNVSARCAVAVDSNSKVVVYEKNAYELVPMASTTKIMTALVAMKYGDLNKKIDISPKAASVRGSTVGYKKGESILLKELLFGLMLRSGNDAAIAIAEGISGSVEEFAKLMNEYAGELGVINTQFQTPHGLDSEGHYSTAYDLALVTSAAKKEPLFNEIVSSKDVDGEKNKFSRSYHNINKILWQIPEANGVKTGYTGKAGKCLVTSVAIEKNDIIIVVLNSPGRWEETDKIYEYVNKNYKFVKLFSKGDIAAELKINRNNLKLQCEDDIVLPIKNGFKYTTKIIKPQKIAYNVKKGDKIGMLCVYENDKKIYSTALIASRDVKIRGFMHRIFGFRGNVNPPEVSIDFQIPKYQAILR
>NZ_CP018335.1|WP_083585669.1|1566646_1567201_-|DUF2953-domain-containing-protein
MEEIMGLFFFLFITLFIVLFFIPFPVKIKIKYSKKNFIFKVYNLNISNKIKSIKDNYSLNYPEVKNRLPLFIRTIKNNLNFVDEIKFKSTLKIDIKIAYGLEDAAHTALVYGFIPLINTLTLNILSKIFIIKQNQIYVTPDFNNLHLKIQINSIIYISLAKIIYTGILLAKYRKKLKKLNPLHT
>NZ_CP018335.1|WP_073538304.1|1565978_1566443_-|sporulation-protein-YtfJ
MDNHPIENLLKSTMENLKDMIDVNTIVGDAVESKDGSFIIPISKVSLGFVSGGSEFNSNNQDTSNLEYPFGGGSGAGVTVKPVAFLVTKGDSIRLLSLNQNNTYDKIVDSIPQIMDLIKGMGSSKCKNPENTHRKEDGKDNKKEEETSKEKTSS
>NZ_CP018335.1|WP_073538303.1|1565259_1565862_+|segregation/condensation-protein-B
MEENLNESICKIGESNSISKDNYFSIIESLLFVSGEPLTLKQIAAIIGCNLEYTRDLINEMAFEYKNCTRGIKILNSNDKYSLVTKSENSSYVEKLLKNNLRQSLSRAALETLAIIAYMQPVTRIDIDEIRGVKSDRALMTLMEKKLIEENGRLSVPGRPILYVTTEEFLKYFGLDSIKEIPGIDDLIDNYESVYKSNES
>NZ_CP018335.1|WP_073538302.1|1564514_1565276_+|segregation/condensation-protein-A
MPLNIKIENFQGPFDLLLHLIKKNKMNIYDIKIHNITEQYIQYINNMKDMDLEVTSEFIVIAASLIEIKSKMLLPKPKLDESAGDDEKDPRKQLVDKLLQYKRFKAAAEFLKERVLNIGKMYGKMPEIIEVKNKPENMEEILKGTDMEKLHEIYKKLIDLYTNKLNKENTVNKNITVDKFKLEDKMEYIVEILESKKKIRFSTVVESCSFKIERIITFVALLELVKLRTISIMQYKNFSEIYIERVIEYGGES
>NZ_CP018335.1|WP_073538311.1|1574384_1575026_+|electron-transport-complex-subunit-E
MKGLWNIFKKGLVSENPILVLALSLCPALATTSSAVNGLTMGLCVLFVITCNNTVVSIIKKFVNPKVRVPVYITCIATIVTVVELVLEAYAPELYSQLGIYLALVVVFAIILARAETFASKNPVIPSFFDGLGMGCGFTLALVLISIIRELFGAGTIFGIHVMWASYNPALIMILPPGAFILIGYLVSLVKVYNQHVEKVKMKKLEQLSGGEV
>NZ_CP018335.1|WP_073538312.1|1575027_1575606_+|RnfABCDGE-type-electron-transport-complex-subunit-A
MAYLTLFISAVIVNNFVLTRFLGLCIFFGVSKNLDASLGMGMAVTSVITLSSMLAWVVYTFVLVPFNLVFLKTVVFVLLIASFVQLLEIIIKKQAPALYNMWGIYLLLIATNCVVLGVPLINAESNYGFIESVVNSIGSGLGFALAIVLMASLREKLRLADVPKPLEGLGVAFILAGMLALSFMGFSGMISL
>NZ_CP018335.1|WP_073538313.1|1575621_1576479_+|Fe-S-cluster-domain-containing-protein
MQTAIMVLIVMTIIGLLFGLILAYVDKKFAVEVNPLIELVEDVLPKGQCGGCGYAGCKAYAEAVVLDESVSPNLCVPGKEEVAKAVAELTGKSAGDVEAKVAHVRCSGDLSNTVKKYDYKGIKDCTAANLLQGGPKACEYGCLGFGTCVKHCPFDALTMGSKGLPIVDTFKCTGCGSCEAACPKSVIQLRPLGSKVQVNCNSKDKGAQVRKSCKVGCLGCGLCMKNCSYDAIKLENNLAVVDHHICIEKCSEATCLAKCPTGAIKKITSAMDLQEQSKEEAAANS
>NZ_CP018335.1|WP_073538314.1|1576555_1577074_-|Gx-transporter-family-protein
MNKTKKLVFLSFLVGMALVIYIIEAQIPVLFPGIKLGLSNTVSLATLILLGWKEALLVMLLRTLLGSMFNGTMTAFMFSIAGGILSNLVMIILYKYFKNSMSLWTISICGAIFHNIGQLLIASIIIQDFKIYIYLPVLLISAIITGYFIGWCTKFLMDNLSRIPIFKSFLDS
>NZ_CP018335.1|WP_073538315.1|1577198_1577855_-|DUF4397-domain-containing-protein
MFICPYCARNFYRAPKFRAVSHIRFLNASPNSPAIDVYLNDRLMFRNLLYKYFSDYVTIPSGTYHIKVFPSGNTVNPLIDKSLFIPPEKIFTLAAIDEYPNIDLLSIEDVRRPKIPGKAFIRFGHLSPEAPTLNVVLPDGNTLFSNVSYKEITPYIPVDPGTYTIEARSSSSDERILYVPNIRLRGDRFYTIYAVGNLSKPPELQVLIPLDGNSYIGS
>NZ_CP018335.1|WP_073538316.1|1577950_1578418_-|hypothetical-protein
MKKFLLILIPVIFLAGLSYKLNNDIFNPRKPNNFYYTNLLAKNLTLSSPLKCTMEENNFHDEINLDKDNIVDIKNMLSSLKKKNFITKPKDLPEKSPYRITFTFNKEKLLIDIYNEKYVCIYPWDGEYPMDYVDISDIPASLNLYYLGKYLFKQY
>NZ_CP018335.1|WP_073538317.1|1578528_1579353_+|Cof-type-HAD-IIB-family-hydrolase
MNYKIIAVDMDGTLLDDERLIPEYNKDMIYKAIKLGVKFVICSGRPPMALKFYSEMVFPDEPVICCNGGVIMGENKNVIKSVPLNKYSLLKVIDILREEKDTYYHFYDDFGLYSEQFRYTTKKFYDINNSLSEKFKMKITIVKNSKTFIKHCRCNITKIVVIDEDVEYLERLRDKIAKVPGITTTKSDLYNIEIVSRGVSKGSALEFLAHYYNIPMEQCIAVGNDENDKSMIKTAGLGVAVFNSREILKKSADYITETDNNSGAVGEVIKKFIL
>NZ_CP018335.1|WP_073538318.1|1579775_1581206_+|anthranilate-synthase-component-I
MLNLNESEFNLLKNNKDVFPVICKLNGDEITPINIFYNLKGENKIIMESVEFNEQKGRYSFITCNPYMEIKSFKNDIFVEHKNSKFKFQGKIMDFIEKYMDINYNTNSVDIPFIGGAIGYAGYDVIKQYENIKDDNEDDLKIPESYFMFYKNLICYDHLKHRLILIYNVFPEDDISYEEINSYFQILYRQITGKIKVHNISNSSKKAEVTSNYTKDEFCRNVEKAKEYIKSGDIFQVVISQRLKCSTELKAFDIYRKLRYENPSSYLFYMDFKDFQVVGSSPERLVSVYGDRVSTNPIAGTRKRGTSREEDEKLKNELINDEKERAEHVMLVDLGRNDIGKVSEFGTVEVTKFMEVQKYSHIMHLVSEVSGKLRSGISSFGAFISCLPAGTVSGAPKIRAMEIIDEIEDRKRLLYAGAVGYFSYNKNMDTCIAIRTVVIKEGYAYMQAGGGIVYDSDPESEYEESLNKAKALMEVV
>NZ_CP018335.1|WP_073538319.1|1581206_1581791_+|aminodeoxychorismate/anthranilate-synthase-component-II
MILMIDNYDSFTYNLYQYIGELYEDIVVVRNDEVSVEDIEKFKNLQGIVISPGPGVPEDSGICIEVIKKYGKDIPILGICLGHQAIAVAYGGDVVRAKEIRHGKTSMVEHVENELFKGIKSPIRAMRYHSLIVDEESIIPTHIIKIAESDDGVLMGIKHSVYPVYGLQFHPESILTECGRGIIKNFLQEVCHVK
>NZ_CP018335.1|WP_073538320.1|1581780_1582788_+|anthranilate-phosphoribosyltransferase
MLNEAIKEVLSGKDLSESQSEQVMENIMNGQEPSTLIAGFLIALKMKGESIPEITGCAKAMRNMAVPVKLKSQYAIDTCGTGGDGGRTFNISTAAAIIAASAGVKVAKHGNRAVSSKSGSADVLKELGININLEKSKVEHCIDNVGMGFLFAPSYHSAMKNVAGIRRDLGVRTIFNILGPLTNPAFVKGQVMGVYDRELLEPAAKTLLNLGCERAMVVHGGDGLDEITTTTVTYVCEVKDGEIRKYTLSPGDFGIKTTFYKNIAGGTARENAAIIMDILKGKTGPERDIVVLNSAAAIYIGKKAEDLKEGVLRANELIDSGKAYAKYEEILNYNN

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Crispr_ID: NZ_CP018335_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018335_2

2065983-2066882

Unclear

Consensus_repeat	Method
GTTTCAATTCCTCATAGGTAATCTAAAATC	CRT
GTTTCAATTCCTCATAGGTAATCTAAAATC	CRISPRCasFinder
GTTTCAATTCCTCATAGGTAATCTAAAATC	PILER-CR

13 spacers

cas6,c2c9_V-U4,cas2,cas1,cas4

The CRISPR arrays of NZ_CP018335_2

>merge|NZ_CP018335|2|2065983-2066882|CRT,CRISPRCasFinder,PILER-CR
AAATAAAGCATACCATGGTAATCTAAAATCTGTGTAATATTGTATACACATTTTTGTTTATTTGTCATTTCAATTCCTCATATGTAGTCTAAAATCATAACTGGTCCGAAAGCTGCTGCTGCAAGCCCAAGAGTTTTAATTCCTCATAGGTAATCTAAAATCCGCAAGTTGAAGGATATAAAACACCTGCGATAGCCATGTTTCAATTCCTCATAGGTAATCTAAAATCCATAAGCCTTTTTAATAATATCTACTACACCATTAAAGTTTCAATTCCTCATAGGTAATCTAAAATCATCTTGTTCAGCTTTTTTCTTCGCTTTAATATCTGCGTTTCAATTCCTCATAGGTAATCTAAAATCCTGCATCCCAGTTGCTATTATTTGAGGAAGGTTTGTAGGTTTCAATTCCTCATAGGTAATCTAAAATCATAGAGGTGCAAAACTACAAAGTAGCTTATATGTACTGTTTCAATTCCTCATAGGTAATCTAAAATCAAACAGAAGTTGAGTTTAATGAGAAAAGATATACTGGTTTCAATTCCTCATAGGTAATCTAAAATCCCTTTCCAGTCCAGGGAGCCAATTCATAGGAGTTCCTGGTTTCAATTCCTCATAGGTAATCTAAAATCTTTCTGGTAGAAATGCAAATACAAAGAAAGATGCATAGTTTCAATTCCTCATAGGTAATCTAAAATCGAAGCAGTAAGAATAGCATATTTTGGAGAATATAAATGGTTTCAATTCCTCATAGGTAATCTAAAATCAGAATTTAAGTTCGTTGAAGTGCGAGTACCAGTGCCGAGTTTCAATTCCTCATAGGTAATCTAAAATCTTGGAGATATAGGATACAGTCTATATTTATACGATAGTTTCAATTCCTCATAGGTAATCTAAAATC

>NZ_CP018335|2|1|2065983-2066882|CRT
AAATAAAGCATACCATGGTAATCTAAAATC	TGTGTAATATTGTATACACATTTTTGTTTATTTGTC
ATTTCAATTCCTCATATGTAGTCTAAAATC	ATAACTGGTCCGAAAGCTGCTGCTGCAAGCCCAAGA
GTTTTAATTCCTCATAGGTAATCTAAAATC	CGCAAGTTGAAGGATATAAAACACCTGCGATAGCCAT
GTTTCAATTCCTCATAGGTAATCTAAAATC	CATAAGCCTTTTTAATAATATCTACTACACCATTAAA
GTTTCAATTCCTCATAGGTAATCTAAAATC	ATCTTGTTCAGCTTTTTTCTTCGCTTTAATATCTGC
GTTTCAATTCCTCATAGGTAATCTAAAATC	CTGCATCCCAGTTGCTATTATTTGAGGAAGGTTTGTAG
GTTTCAATTCCTCATAGGTAATCTAAAATC	ATAGAGGTGCAAAACTACAAAGTAGCTTATATGTACT
GTTTCAATTCCTCATAGGTAATCTAAAATC	AAACAGAAGTTGAGTTTAATGAGAAAAGATATACTG
GTTTCAATTCCTCATAGGTAATCTAAAATC	CCTTTCCAGTCCAGGGAGCCAATTCATAGGAGTTCCTG
GTTTCAATTCCTCATAGGTAATCTAAAATC	TTTCTGGTAGAAATGCAAATACAAAGAAAGATGCATA
GTTTCAATTCCTCATAGGTAATCTAAAATC	GAAGCAGTAAGAATAGCATATTTTGGAGAATATAAATG
GTTTCAATTCCTCATAGGTAATCTAAAATC	AGAATTTAAGTTCGTTGAAGTGCGAGTACCAGTGCCGA
GTTTCAATTCCTCATAGGTAATCTAAAATC	TTGGAGATATAGGATACAGTCTATATTTATACGATA
GTTTCAATTCCTCATAGGTAATCTAAAATC

>NZ_CP018335|2|2|2066049-2066882|CRISPRCasFinder
ATTTCAATTCCTCATATGTAGTCTAAAATC	ATAACTGGTCCGAAAGCTGCTGCTGCAAGCCCAAGA
GTTTTAATTCCTCATAGGTAATCTAAAATC	CGCAAGTTGAAGGATATAAAACACCTGCGATAGCCAT
GTTTCAATTCCTCATAGGTAATCTAAAATC	CATAAGCCTTTTTAATAATATCTACTACACCATTAAA
GTTTCAATTCCTCATAGGTAATCTAAAATC	ATCTTGTTCAGCTTTTTTCTTCGCTTTAATATCTGC
GTTTCAATTCCTCATAGGTAATCTAAAATC	CTGCATCCCAGTTGCTATTATTTGAGGAAGGTTTGTAG
GTTTCAATTCCTCATAGGTAATCTAAAATC	ATAGAGGTGCAAAACTACAAAGTAGCTTATATGTACT
GTTTCAATTCCTCATAGGTAATCTAAAATC	AAACAGAAGTTGAGTTTAATGAGAAAAGATATACTG
GTTTCAATTCCTCATAGGTAATCTAAAATC	CCTTTCCAGTCCAGGGAGCCAATTCATAGGAGTTCCTG
GTTTCAATTCCTCATAGGTAATCTAAAATC	TTTCTGGTAGAAATGCAAATACAAAGAAAGATGCATA
GTTTCAATTCCTCATAGGTAATCTAAAATC	GAAGCAGTAAGAATAGCATATTTTGGAGAATATAAATG
GTTTCAATTCCTCATAGGTAATCTAAAATC	AGAATTTAAGTTCGTTGAAGTGCGAGTACCAGTGCCGA
GTTTCAATTCCTCATAGGTAATCTAAAATC	TTGGAGATATAGGATACAGTCTATATTTATACGATA
GTTTCAATTCCTCATAGGTAATCTAAAATC

>NZ_CP018335|2|1|2066115-2066882|PILER-CR
GTTTTAATTCCTCATAGGTAATCTAAAATC	CGCAAGTTGAAGGATATAAAACACCTGCGATAGCCAT
GTTTCAATTCCTCATAGGTAATCTAAAATC	CATAAGCCTTTTTAATAATATCTACTACACCATTAAA
GTTTCAATTCCTCATAGGTAATCTAAAATC	ATCTTGTTCAGCTTTTTTCTTCGCTTTAATATCTGC
GTTTCAATTCCTCATAGGTAATCTAAAATC	CTGCATCCCAGTTGCTATTATTTGAGGAAGGTTTGTAG
GTTTCAATTCCTCATAGGTAATCTAAAATC	ATAGAGGTGCAAAACTACAAAGTAGCTTATATGTACT
GTTTCAATTCCTCATAGGTAATCTAAAATC	AAACAGAAGTTGAGTTTAATGAGAAAAGATATACTG
GTTTCAATTCCTCATAGGTAATCTAAAATC	CCTTTCCAGTCCAGGGAGCCAATTCATAGGAGTTCCTG
GTTTCAATTCCTCATAGGTAATCTAAAATC	TTTCTGGTAGAAATGCAAATACAAAGAAAGATGCATA
GTTTCAATTCCTCATAGGTAATCTAAAATC	GAAGCAGTAAGAATAGCATATTTTGGAGAATATAAATG
GTTTCAATTCCTCATAGGTAATCTAAAATC	AGAATTTAAGTTCGTTGAAGTGCGAGTACCAGTGCCGA
GTTTCAATTCCTCATAGGTAATCTAAAATC	TTGGAGATATAGGATACAGTCTATATTTATACGATA
GTTTCAATTCCTCATAGGTAATCTAAAATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018335.1\|WP_083585692.1\|2067887_2068562_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|273848
NZ_CP018335.1\|WP_073538684.1\|2057893_2059342_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP018335.1\|WP_073538697.1\|2076994_2078245_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP018335.1\|WP_012102036.1\|2076377_2076704_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP018335.1\|WP_073541244.1\|2053653_2054832_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|99738
NZ_CP018335.1\|WP_083585690.1\|2056513_2057812_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NZ_CP018335.1\|WP_073538689.1\|2067050_2067809_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP018335.1\|WP_073538694.1\|2071370_2072363_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NZ_CP018335.1\|WP_073538687.1\|2061916_2062672_+\|serine-protease	unknown	unknown	gnl\|CDD\|131955
NZ_CP018335.1\|WP_073538682.1\|2054931_2056143_-\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NZ_CP018335.1\|WP_073538696.1\|2075401_2076373_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018335.1\|WP_073538680.1\|2050150_2052316_+\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
NZ_CP018335.1\|WP_073538681.1\|2052653_2053568_+\|homoserine-O-succinyltransferase	unknown	unknown	gnl\|CDD\|235433
NZ_CP018335.1\|WP_073538691.1\|2068743_2069910_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	c2c9_V-U4	-	gnl\|CDD\|223747
NZ_CP018335.1\|WP_073538688.1\|2062895_2063999_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018335.1\|WP_073538686.1\|2060102_2060816_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NZ_CP018335.1\|WP_073538693.1\|2071104_2071368_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP018335.1\|WP_073538692.1\|2069902_2070511_-\|IS607-family-transposase	unknown	unknown	gnl\|CDD\|239738
NZ_CP018335.1\|WP_083585693.1\|2072383_2072875_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP018335.1\|WP_083585691.1\|2059432_2060077_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
NZ_CP018335.1\|WP_083585692.1\|2067887_2068562_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.00313e-35
NZ_CP018335.1\|WP_073538684.1\|2057893_2059342_-\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	2.44405e-36
NZ_CP018335.1\|WP_073538697.1\|2076994_2078245_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.00592e-42
NZ_CP018335.1\|WP_012102036.1\|2076377_2076704_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.30879e-16
NZ_CP018335.1\|WP_073541244.1\|2053653_2054832_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|99738	cd00614, CGS_like, CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.	4.78914e-145
NZ_CP018335.1\|WP_083585690.1\|2056513_2057812_-\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	2.14405e-125
NZ_CP018335.1\|WP_073538689.1\|2067050_2067809_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	3.85787e-21
NZ_CP018335.1\|WP_073538694.1\|2071370_2072363_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.55557e-161
NZ_CP018335.1\|WP_073538687.1\|2061916_2062672_+\|serine-protease	gnl\|CDD\|131955	TIGR02909, conserved_hypothetical_protein, uncharacterized protein, YkwD family. Members of this protein family represent a subset of those belonging to pfam00188 (SCP-like extracellular protein). Based on currently cuttoffs for this model, all member proteins are found in Bacteria capable of endospore formation. Members include a named but uncharacterized protein, YkwD of Bacillus subtilis. Only the C-terminal region is well-conserved and is included in the seed alignment for this model. Three members of this family have an N-terminal domain homologous to the spore coat assembly protein SafA.	3.53376e-72
NZ_CP018335.1\|WP_073538682.1\|2054931_2056143_-\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NZ_CP018335.1\|WP_073538680.1\|2050150_2052316_+\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	5.13002e-107
NZ_CP018335.1\|WP_073538681.1\|2052653_2053568_+\|homoserine-O-succinyltransferase	gnl\|CDD\|235433	PRK05368, PRK05368, homoserine O-succinyltransferase; Provisional.	0
NZ_CP018335.1\|WP_073538691.1\|2068743_2069910_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.19921e-35
NZ_CP018335.1\|WP_073538693.1\|2071104_2071368_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.03327e-30
NZ_CP018335.1\|WP_073538686.1\|2060102_2060816_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	6.42314e-38
NZ_CP018335.1\|WP_073538692.1\|2069902_2070511_-\|IS607-family-transposase	gnl\|CDD\|239738	cd03769, SR_IS607_transposase_like, Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.	3.43882e-47
NZ_CP018335.1\|WP_083585693.1\|2072383_2072875_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.55821e-69
NZ_CP018335.1\|WP_083585691.1\|2059432_2060077_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	8.04017e-20

>NZ_CP018335.1|WP_073538688.1|2062895_2063999_-|hypothetical-protein
MNTISNDQNTINWYNQSIQKILSSQVETSTNEDENKTESSIGSIGQAYRSSIFAGGTSNIINSLDNLVSNGTITEDQETIIQNAFNAAFKSNQTNSGTYNKVSNPLDNLVSSGIITQEQKTAIESNFKPDETKENNNVNPLDTLVSNGTITQEQENAVQSALESAFSENETQQKSDNGLTSTLDSLVSDGTITQAQEDAIKSAFESVFAQSHIQGRKDDGVDSVLDDLVSEGTITQEQKTAIQESFKSAFKSGKSEENNNINPLDSLVSSGIITQEQENAIQSAFENARTESESQEKGNNALTSVLDNLVSDNTISQDQEDAIKSAFESIFGQREKQGNSRIDSILDNLVSDGTITQEQEEAIQSIF
>NZ_CP018335.1|WP_073538687.1|2061916_2062672_+|serine-protease
MNKKIKLLIASLIIASGIPTVIPTMAKAASNTCSSPVVQQVSLKYDLNNYSQLKNCLKNYTVVTSKNACKNNNSTTKPTTNNNGTSTTKPTENTGNTGNTGNTGQTSTTTKPTENSGQTSTISAEANEVIRLVNVERSKNGLSPLKANAELSKVATAKAQDMIDNSYFSHTSPTYGSPFDMMKKFGISYTAAGENIAYGQKDAAEVMNSWMNSSGHRANILNSNFTEIGVGVAKDKNGTPYWVQMFINPGK
>NZ_CP018335.1|WP_073538686.1|2060102_2060816_-|type-1-glutamine-amidotransferase
MRIAEFIHDNDYPKLTNLDYWLKDNLNYETKKIVIDEHTRFSEIKDFDLIVLHGGIQHLWDKEQDPWLYKEIEYIKWALNNNKAVIGFCLGSQIIAEALGEMVYKAHKEEIGWFRVQLRAEAEEHILLKDLGQNFISFMCHSDHYDLPENCSSLAFTETAKNQIFVSNKFPTIGFQFHPEYTLKNIKVLLETFNDKDCFGEEYRLRKVNIIEQTKAFSSTYGLFKKLMDNSLKWFFK
>NZ_CP018335.1|WP_083585691.1|2059432_2060077_-|TetR/AcrR-family-transcriptional-regulator
MLKTFKQLSREKQTYILNAAASVFAEEGYHHATINNICKEAGISNGALYKYFKNKDSLFFSVLDYITNILEEKVYRANVEKSKFLYDYIYNLLKGIEQLIEDYPDYISIYCDLGSSSMKRFATKSSEKLRKATSIYTIKMVKESKKHGDIDKNIKDEVAAYLIDNYITLFAYSLVSEYHSKRMNAFFCSKNTILSNEDKLNLTVESLKCALKSL
>NZ_CP018335.1|WP_073538684.1|2057893_2059342_-|APC-family-permease
MSNIKKNNFEENKVGLKSEYLSFIEILAQSVGSIAPTASLAFVIPLVYGTAGNGTWLAYAFALIAILFVAINLNQFTSRSASSGSLYMYIVSGLGPTVGFISGWALLLAYGLTTSAVLSGFINFANVLLQYLGINIPLVALGIVGAATAWYVAYKDIKLSAKLTLILEAVSIISISILGIIVVVHNGFKIDLAQLTLKDVSPSSIRIGLVIAFFSYVGFESASSLGEEAKRPLYTIPKAVLVSSAIVGILFIIFAYIEVLGYIGSKIKLNEAQAPLTTLANLNSVGFFGVIISLGTLFSFWASFLACANAGARVLFSIGRHGIVNSSMSNVHKNNKTPHISIALISLIATVIPIILICLHNGIFDIYGWLGTIATFGFLFNYALVTIASPVYLYKEKELKPKHIIVSIVTFIILLIPIVGSIYPLPVYPYNIFPFMFLAWLAAGAIWFFICKAKNPNLVSDIEVNVKDINEQFKIDRKKSAI
>NZ_CP018335.1|WP_083585690.1|2056513_2057812_-|glutamine-synthetase
MIDELEKIIKEKGIHTIEVVHADTLGILGAKMIPAKSFLKNYKSGFGVCRASLGWDIQGNLFEGVEITDFNTGCPDVIVKPILSTFREIPWRKGSAFVFGEIYEENGEIFKYAPREILKKLVIRYEQLKYRPLVGVELEFYLLDNERQKLHQGIHTYSLSKGLELEYILGEIRNNLNDIGIELEATHMEYGPAQVEIITEYGDALDAADKTVLLKSIVKEAARKYDLYATFMAKPWTQESGSGFHVHQSLWNLELNKNIFQHDKKIANRYLAGLTNTTSEFMAFTSPSINSYKRFNKYSFAPVSESWGYDNRTVAVRSLLSNGKGSRLEQRIGSSDANPYLAIAASLAGGLYGLENELNLCESTSTDAYLTTEKLLPKNLEQALDKLEKSKIAKKYFNEEFIKLFLAIGRNEINLYEQSVTDWEFNRYLEYS
>NZ_CP018335.1|WP_073538682.1|2054931_2056143_-|methionine-adenosyltransferase
MSRLFTSESVTEGHPDKICDQISDAILDAIIEKDENGRVACETVVNTGIVILVGEISTKAYIDIPKIVRKTISDIGYSNSKFGFDAASCAIITSIDEQSLDIALGVNDSLESRNGEKDNIEAIGAGDQGIVFGFATNETPEYLPLPIVLAHKLAKKLSEVRKSNIIPYLGPDGKTQVTVEYEKGKPVRIDTVLVSSQHEDNVNHDEIEKDIIDKVIKAAIPSGLLDSHTKYLINPTGRFVKGGPEADSGLTGRKIIVDSYGGYGRHGGGAFSGKDPTKVDRSGAYAARWVAKNLVAAGIADKIEIEIAYAIGVASPVSVSVDTFGTGKVISDDQIVEIINEVFDLRPAAIIKELDLRRPIYKNTAAYGHFGRTDIDAPWERFDKVDEIKNIYKKNYQQLVSSF
>NZ_CP018335.1|WP_073541244.1|2053653_2054832_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MIDKNNIDFITKCIHVGNGIDKETGAIRRPITMANCYRLPEDASSINWSDADQLLYTRNTSANQVYLQEKLASLEGGEDCVVLASGVSALAGVFFSFLNKESHVICSNVSYIAVYRLLNEYLPDKYGIETSLVDTSNLEKIKKAIRPNTKLIHIETPGNPTTKISDIEEISKIAKSIGALLSVDSTFASPFLQRPLQLGADLVIHSLTKYINGHGDAMGGAVIGKKELIDKIKREAMVNLGGTISPFNAWLIMRGVVTLPLRMKQHSDTALEVAEFLESNPVVKFAAYPGLESHPQHDIAKKQMNMYSGIIAFALKADVDTHNKFINSLELITQAVSLGHDESLIVYTGPSDERINFYPEQFREGYIRFSIGLESASDIIADLKQALKKCGL
>NZ_CP018335.1|WP_073538681.1|2052653_2053568_+|homoserine-O-succinyltransferase
MPINIPNNLPASKVLKAENIFVMNENHAVRQDIRPLNIIILNLMPLKTVTEIQLLRLLSNSPIQVDISLMYLKSHNSKNTPAEYLIKYYETFEEIKDKKFDGMIITGAPVEKFEFEDVDYWKELTEIMDWSTRNVYSTMYICWASQAGLYHHFKVPKYALEQKISGIFSHTLNKANIKLFRGFDDVFHAPHSRYTFVKRNDIERVPELKIISESKEAGVYIVATKGGRQIFIAGHPEYDTLTLKSEYERDIALNLPIDVPKNYFPDDNPDKMPLSNWKSHSNLLFLNWLNYYVYQETPYDLNKL
>NZ_CP018335.1|WP_073538680.1|2050150_2052316_+|YhgE/Pip-domain-containing-protein
MKTIFKILKRDLINIIKNPSVFIVILGFCVLPSLYAWINIKASWNPYAEINTRRLPIAVINNDSGSTFNNKNINIGNEVVKELKKNTTLDWVFIDEWQGNYGLNTGKYYALIEIPQDFSSKMLTVTTQSPEKPNIIYRSNEKLNAVATKITDSAKTNLINKIKSNFIKTASQEVFKELNSLGKDLETDKPQIIQLKDTIPETVSSINDIKKYISEINTSSEELQKYLNTQKSDFPKLLQQINSVQNILAQSKLLVLSTKQTLNSTQNNLNNDINEIQSLNNQIQDLLTNLNNINKINIGSDLNITVINQLINLDNSLIKKINNTLDILDFINDFLPNKGASELIDSLNILKNSVQTEKTYLNRLKSLINSNSSEDNITSVINELSNLSNQISMNVVSVSNAFYLDTYQSIDIATDNLTNSLNNIDFILESTKVLVPQLNTLANSEILSSKASVSQTDNLNKKLEDIQSKLNELSSKMENLNEENLNEIIDFMEKNPDELSNLLSSPINIKNVEVYNSGLFGYAVTPFYTTLAIWVGVLLLSSILSFHCKDFDDNKKLTVTHKYFGKLVLFLILSFIQTIITILGDVYLIKVYPQSMGLMILISLACSITFTIIIYTLASILGNIGKAIAVIIMVFQIAGAGGIYPIETLPKIFSTLAPFWPFTYAIRGFREAIGGPLWKDVYKDLIAMAGFSCVFLLLSLLKRPLHNLIEISEHKFRESGL
>NZ_CP018335.1|WP_073538689.1|2067050_2067809_-|Fic-family-protein
MSYKDCIKVWRKGISEELLDRFFLKFTYSSNKIENNETRLRDVETIFKGKKVADFKGNKKTLVEIENHRELCKNIFKLCKKYDSKVSIDLAKKIHYALMKNCFSEQLLLKGESPGEFKKGDYIVGLHDVGVSPDEVEENLDSLFKEINEVKINDNNVLTVISYFHCWFENIHPFADGNGRTGRMLVNYLLIGNNFPPIVLFENDREQYYLALEYFNETQEISKMVDFLEDQAYKTWIKDYNIKLKNLKDFLD
>NZ_CP018335.1|WP_083585692.1|2067887_2068562_-|CRISPR-associated-endoribonuclease-Cas6
MQAVILNWLGNENYQKFIHDCGFKFENRRYKLFTFSKIYGKFKIYRDKKIISFFDNANFTVSSLEDRFLNYLVLNVIAKDNFKFGNNIVGIEGIESAYSKLSEKEIVYTKSPIVVYSTFQNYQGNKTYYYNPLESEFSELIRRNLIHKYKAYYGAEPSDKCFSITPLYREKLKQRIVMYKGYVIKGWDGEFLIQGSKELMDIAYNAGIGSKNSQGFGCIEVKRK
>NZ_CP018335.1|WP_073538691.1|2068743_2069910_-|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MIRGIKVRLYPTKEQEILMWKSAGVARFTYNWGLAYLNSYYKENKKSLSIGELRKIFTELRNSEEYPWIREVSSEIPQQALKDLGDAFEEFFEDEHGYPKFKKKNKCENSFFHLNNKFVVKDKFIKLERIGFVKMKDEGRLPIGNYKKDKIKVTNPRIKHNGHHWYLSLGFEVENTHKLCLTGESIGVDLGIKELAVVSNIDKPFKNINKSKKVKKLNKRLLKLQRQISRKYDKLKSEKAFKKSEKPNKTNNIIKLEKKIKLLHKKISDIRLNHIHQTTNAIVKTKPSRVVVEDLNVTGLLKNKHLSKAIQEQSFNKFINTLEYKCEWNGIEFVKADRFYPSSKKCSCCGAIKKDLKLSDRIYKCACGIVIDRDKNASIDLANYKLVG
>NZ_CP018335.1|WP_073538692.1|2069902_2070511_-|IS607-family-transposase
MKKYPIGQFAKIINRSQQTLRNWDNANKLKPEYVDPKTGYRYYTDKQLKEFNGEVNKDNKIVVGYCRVSSSKQKEALERQIENVRIYLISKGYKFKIISDIGSGINYDKKGLNELIELILQNQVSKVVILYKDRLVRFGYELIKNICDYKNVEIEIIDNTEKTEEEEVVEDLVQIISVFSCRLQGKIANKTKKMIKELTEDD
>NZ_CP018335.1|WP_073538693.1|2071104_2071368_-|CRISPR-associated-endonuclease-Cas2
MFVILVYDFGEKRVGKALKLCRRYLTWVQNSVFEGELSMANFKKLKIEIENIMDKKEDSVIIYKFNSTKYSKREQIGVVKNSQELFI
>NZ_CP018335.1|WP_073538694.1|2071370_2072363_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKDIYIFNDGELKRKENTIYFEGEDNKKHIPVEEIDTIWIFGEVTLNKRFLDFVSQKEICLHFFNYFGYYMGSFYPREHYNSGYVILKQCEFYLDFDKRINIARKIIQTAVENIIVVLKYYKSRGIELESEITDIFNKSKTMEGTESIEQLMALEGNIREKYYTCFNKIIKNEEFKFRGRSKRPPKDNINALISFGNSVMYSTVLGEIYHTHLDPRIGYLHSTNMRRFTLNLDIAEIFKPIMVDRCIFSLLNKNIITVKDFQEEFNGILLSESGKKKFLQEYNSKLYTTIKHPNLNKPVSYKRLIRMELYKIQKHITQDEEYVGFIARW
>NZ_CP018335.1|WP_083585693.1|2072383_2072875_-|CRISPR-associated-protein-Cas4
MDINGVFLWYYNICKRELWLMSRKIVPDQQDENVDIGRFIHQNTYKRNKKEISFGNIKFDVIFRSKDNMVIGETKKSSKYKEASKWQLMFYLKTLKDAGIHASGQLLYPEERKREEVILDDTSSKELAEMISHIEYICSLDKPPGVKKIPYCKNCAYREYCFA
>NZ_CP018335.1|WP_073538696.1|2075401_2076373_-|hypothetical-protein
METIKNYLDNVFAALPKTDELFKLKNDLLINMEEKYNELKSEKKSENEAIGIVISEFGNIDELIGELGVNLHEDEMNFPTITEEEVKNYMTMKKQTGILVGIGVFLCITGTALLILITTLVDEGIIGRGFSEDTGYMIGLITLFVMIVPAVALFIYSGMKSERYKYLKKGFNVPLSVKSLLQQRYNDFTSTYMVSLILGVCLCVLSPVSIFAASVFGDTASIYGVIILLIIIAIAVFIFIYYGSIKESFTFILRIDNFSKENVENNKVIGAVAAIIWPLAVCIFLVSGLVFDKWYINWIVFPITGILFGMFSSVYSIIKKRKN
>NZ_CP018335.1|WP_012102036.1|2076377_2076704_-|PadR-family-transcriptional-regulator
MISSDVIRGYNDIIILFMLLEDESYGYEISKNIRRLSEDKYIIKETTLYSTFNRLEKNKYIESFYKDETFGKRRTYYRITPLGRVYYKEKCREWDLTKEVINKFIKES
>NZ_CP018335.1|WP_073538697.1|2076994_2078245_-|HAMP-domain-containing-histidine-kinase
MILYYENPEIKRSSCIILILAIAFIAVNSFILHRGYEMVKKDYINNNVALIGKIVRIHPELEDEVVPIITKESSLKDVEFGIKILNKYDYKENLNINLLPGLKEDYSTLSKSMLFSMACFFIIVFLINSMEYVKMYRKLESLMFAAKNVIDYNFDVGIYENTEGIFARLAHTFNNMRAILKNNLIQIQKEKNFLINTLSDISHQIKTPISSLIIYNDILLNRKINEEKKIEFLRISQNQLNRIQWLVKSLLQLARLDVGAVRFEIKSNDINKTVTASIESLKIKSESANVKVEFYPEENEIMINHDPNWINEAIINIIKNAIEHTKPGGKVQVFTEKSQVCSRIIVKDNGEGIHREEIKHIFERFYKGRTNRSEESIGIGLALSKSIIEGNQGMINVKSKIGKGTTFEVVFLNRFI

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Crispr_ID: NZ_CP018335_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018335_3

2073041-2075074

Unclear

Consensus_repeat	Method
GTTTCAATTCCTCATAGGTAATCTAAAATC	CRISPRCasFinder
GTTTCAATTCCTCATAGGTANTCTAAAATC	CRT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	PILER-CR

30 spacers

cas4,cas1,cas2,c2c9_V-U4,cas6

The CRISPR arrays of NZ_CP018335_3

>merge|NZ_CP018335|3|2073041-2075074|CRISPRCasFinder,CRT,PILER-CR
ATTCAAATTCCTCATAGGTAATCTAAAATCCTTTAGAATATTTTCTATGTGTTTTGTTATAGTCTGGTTTCAATTCCTCATAGGTAATCTAAAATCTGAAATTTTAGGTGATGGTGGAGTCCAACAAGTAACTAGTTTCAATTCCTCATAGGTAATCTAAAATCTTAAATGAAACAATAAAAGAGTATAATGAAACAATGTTTCAATTCCTCATAGGTAATCTAAAATCCTGCTCTAAATGCAGTTACGTTAACAACAGATCAAAGTTTCAATTCCTCATAGGTAATCTAAAATCTAACTATTTTCAACCTGTTTGCTCTCAGTAAATTTAGTTTCAATTCCTCATAGGTAATCTAAAATCATGAGAAAAGCTAACATAAAGAGCATAGATTTAACTTAGTTTCAATTCCTCATAGGTAATCTAAAATCAGGCAGTTACTCCTTTGAATTTAAAAACTGAATTAGAGTTTCAATTCCTCATAGGTAATCTAAAATCTACTAGGTTCCCTTTTTCTTTGCCTTGGGATTTATAGTTTCAATTCCTCATAGGTAGTCTAAAATCTGGTAGTTATACAATTCCTTTTTCTTTGGCTAAAGCCCTGTTTCAATTCCTCATAGGTAGTCTAAAATCCAATATTTTTTCAAAACGCTCTTTTTGCTTAATCTGTTTCAATTCATCATAGGTAGTCTAAAATCTTGCTTGCATTTCCTGTATTATCCAAAGTTATAGCTTGTTTCAATTCCTCATAGGTAGTCTAAAATCTGTCACATCCATGATAGCCTGTTGTTCTTGAGGAGGTTTCAATTCCTCATAGGTAGTCTAAAATCCTGTGTAACTGCTATTGCTCCCGCATGATATTTTCGTTTCAATTCCTCATAGGTAGTCTAAAATCTTTCATTGTCATTATTCATTTCCCTCCATTTTCTTTTGTTTCAATTCCTCATAGGTAGTCTAAAATCTTTCAAGATGAAGAATATGATTGGCATATCAAAGATGTGTTTCAATTCCTCATAGGTAGTCTAAAATCTGAAAATGGTAGAAAAAACATTTGAGACTTGTTCTACGTTTCAATTCCTCATAGGTAGTCTAAAATCAGAAAAACTAGGAGCTAATGTCGGAGATACAGTGGAGGGTTTCAATTCCTCATAGGTAGTCTAAAATCGGACAAATTATTGCTATTACTAAGTTACAAGAATGTTAGTTTCAATTCCTCATAGGTAGTCTAAAATCTGAAAAGTGCTGTATTGCAGCAGTATCCTAAGAAAAAGTTTCAATTCCTCATAGGTAGTCTAAAATCTTTTTCTTACTCACATCATTTCCCTCCAATTCTTCTTTGTTTCAATTCCTCATAGGTAGTCTAAAATCCTTAGTGGATTCTAAAGAAGGAAAAACACATTCCCTTTGTTTCAATTCCTCATAGGTAGTCTAAAATCAATCTTTTATTGTATAACTGTCCTTATGTATTATAAGTTTCAATTCCTCATAGGTAGTCTAAAATCTATAAGATAGCATTTCTTGTTTTGCACCATATCTAAGTTTCAATTCCTCATAGGTAGTCTAAAATCCAGGAAAAGGAAAAGAAAGATATATGCTGGTTGATGAGTTTCAATTCCTCATAGGTAGTCTAAAATCTATTAAATCCAGATTGGACTTGCAGAGGTATGCAATAGTTTCAATTCCTCATAGGTAGTCTAAAATCTAGTCAGGAGGAATAAAGTATGATTTTTTTTAAAAGGTTTCAATTCCTCATAGGTAGTCTAAAATCGTATCCGCCTAACACGATTTTTCATTAATCAATGAGAGTTTCAATTCCTCATAGGTAATCTAAAATCAAATACGTTCTTTGATAGAAACGGAGAAGGTGCATCGGTTTCAATTCCTCATAGGTAATCTAAAATCTTAAAACGTGGAAAGGATGTAATATGTAATTTTCCTAGTTTCAATTCCTCATAGGTAATCTAAAATCCCAAGCCTTGAAGACTTAAAACAATCATTTCTTTTTTGTTTCAATTCCTCATAGGTAATCTAAAATC

>NZ_CP018335|3|3|2073041-2075074|CRISPRCasFinder
ATTCAAATTCCTCATAGGTAATCTAAAATC	CTTTAGAATATTTTCTATGTGTTTTGTTATAGTCTG
GTTTCAATTCCTCATAGGTAATCTAAAATC	TGAAATTTTAGGTGATGGTGGAGTCCAACAAGTAACTA
GTTTCAATTCCTCATAGGTAATCTAAAATC	TTAAATGAAACAATAAAAGAGTATAATGAAACAAT
GTTTCAATTCCTCATAGGTAATCTAAAATC	CTGCTCTAAATGCAGTTACGTTAACAACAGATCAAA
GTTTCAATTCCTCATAGGTAATCTAAAATC	TAACTATTTTCAACCTGTTTGCTCTCAGTAAATTTA
GTTTCAATTCCTCATAGGTAATCTAAAATC	ATGAGAAAAGCTAACATAAAGAGCATAGATTTAACTTA
GTTTCAATTCCTCATAGGTAATCTAAAATC	AGGCAGTTACTCCTTTGAATTTAAAAACTGAATTAGA
GTTTCAATTCCTCATAGGTAATCTAAAATC	TACTAGGTTCCCTTTTTCTTTGCCTTGGGATTTATA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TGGTAGTTATACAATTCCTTTTTCTTTGGCTAAAGCCCT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	CAATATTTTTTCAAAACGCTCTTTTTGCTTAATCT
GTTTCAATTCATCATAGGTAGTCTAAAATC	TTGCTTGCATTTCCTGTATTATCCAAAGTTATAGCTT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TGTCACATCCATGATAGCCTGTTGTTCTTGAGGAG
GTTTCAATTCCTCATAGGTAGTCTAAAATC	CTGTGTAACTGCTATTGCTCCCGCATGATATTTTC
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TTTCATTGTCATTATTCATTTCCCTCCATTTTCTTTT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TTTCAAGATGAAGAATATGATTGGCATATCAAAGATGT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TGAAAATGGTAGAAAAAACATTTGAGACTTGTTCTAC
GTTTCAATTCCTCATAGGTAGTCTAAAATC	AGAAAAACTAGGAGCTAATGTCGGAGATACAGTGGAGG
GTTTCAATTCCTCATAGGTAGTCTAAAATC	GGACAAATTATTGCTATTACTAAGTTACAAGAATGTTA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TGAAAAGTGCTGTATTGCAGCAGTATCCTAAGAAAAA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TTTTTCTTACTCACATCATTTCCCTCCAATTCTTCTTT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	CTTAGTGGATTCTAAAGAAGGAAAAACACATTCCCTTT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	AATCTTTTATTGTATAACTGTCCTTATGTATTATAA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TATAAGATAGCATTTCTTGTTTTGCACCATATCTAA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	CAGGAAAAGGAAAAGAAAGATATATGCTGGTTGATGA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TATTAAATCCAGATTGGACTTGCAGAGGTATGCAATA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TAGTCAGGAGGAATAAAGTATGATTTTTTTTAAAAG
GTTTCAATTCCTCATAGGTAGTCTAAAATC	GTATCCGCCTAACACGATTTTTCATTAATCAATGAGA
GTTTCAATTCCTCATAGGTAATCTAAAATC	AAATACGTTCTTTGATAGAAACGGAGAAGGTGCATCG
GTTTCAATTCCTCATAGGTAATCTAAAATC	TTAAAACGTGGAAAGGATGTAATATGTAATTTTCCTA
GTTTCAATTCCTCATAGGTAATCTAAAATC	CCAAGCCTTGAAGACTTAAAACAATCATTTCTTTTTT
GTTTCAATTCCTCATAGGTAATCTAAAATC

>NZ_CP018335|3|2|2073041-2075074|CRT
ATTCAAATTCCTCATAGGTAATCTAAAATC	CTTTAGAATATTTTCTATGTGTTTTGTTATAGTCTG
GTTTCAATTCCTCATAGGTAATCTAAAATC	TGAAATTTTAGGTGATGGTGGAGTCCAACAAGTAACTA
GTTTCAATTCCTCATAGGTAATCTAAAATC	TTAAATGAAACAATAAAAGAGTATAATGAAACAAT
GTTTCAATTCCTCATAGGTAATCTAAAATC	CTGCTCTAAATGCAGTTACGTTAACAACAGATCAAA
GTTTCAATTCCTCATAGGTAATCTAAAATC	TAACTATTTTCAACCTGTTTGCTCTCAGTAAATTTA
GTTTCAATTCCTCATAGGTAATCTAAAATC	ATGAGAAAAGCTAACATAAAGAGCATAGATTTAACTTA
GTTTCAATTCCTCATAGGTAATCTAAAATC	AGGCAGTTACTCCTTTGAATTTAAAAACTGAATTAGA
GTTTCAATTCCTCATAGGTAATCTAAAATC	TACTAGGTTCCCTTTTTCTTTGCCTTGGGATTTATA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TGGTAGTTATACAATTCCTTTTTCTTTGGCTAAAGCCCT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	CAATATTTTTTCAAAACGCTCTTTTTGCTTAATCT
GTTTCAATTCATCATAGGTAGTCTAAAATC	TTGCTTGCATTTCCTGTATTATCCAAAGTTATAGCTT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TGTCACATCCATGATAGCCTGTTGTTCTTGAGGAG
GTTTCAATTCCTCATAGGTAGTCTAAAATC	CTGTGTAACTGCTATTGCTCCCGCATGATATTTTC
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TTTCATTGTCATTATTCATTTCCCTCCATTTTCTTTT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TTTCAAGATGAAGAATATGATTGGCATATCAAAGATGT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TGAAAATGGTAGAAAAAACATTTGAGACTTGTTCTAC
GTTTCAATTCCTCATAGGTAGTCTAAAATC	AGAAAAACTAGGAGCTAATGTCGGAGATACAGTGGAGG
GTTTCAATTCCTCATAGGTAGTCTAAAATC	GGACAAATTATTGCTATTACTAAGTTACAAGAATGTTA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TGAAAAGTGCTGTATTGCAGCAGTATCCTAAGAAAAA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TTTTTCTTACTCACATCATTTCCCTCCAATTCTTCTTT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	CTTAGTGGATTCTAAAGAAGGAAAAACACATTCCCTTT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	AATCTTTTATTGTATAACTGTCCTTATGTATTATAA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TATAAGATAGCATTTCTTGTTTTGCACCATATCTAA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	CAGGAAAAGGAAAAGAAAGATATATGCTGGTTGATGA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TATTAAATCCAGATTGGACTTGCAGAGGTATGCAATA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TAGTCAGGAGGAATAAAGTATGATTTTTTTTAAAAG
GTTTCAATTCCTCATAGGTAGTCTAAAATC	GTATCCGCCTAACACGATTTTTCATTAATCAATGAGA
GTTTCAATTCCTCATAGGTAATCTAAAATC	AAATACGTTCTTTGATAGAAACGGAGAAGGTGCATCG
GTTTCAATTCCTCATAGGTAATCTAAAATC	TTAAAACGTGGAAAGGATGTAATATGTAATTTTCCTA
GTTTCAATTCCTCATAGGTAATCTAAAATC	CCAAGCCTTGAAGACTTAAAACAATCATTTCTTTTTT
GTTTCAATTCCTCATAGGTAATCTAAAATC

>NZ_CP018335|3|2|2073107-2075074|PILER-CR
GTTTCAATTCCTCATAGGTAATCTAAAATC	TGAAATTTTAGGTGATGGTGGAGTCCAACAAGTAACTA
GTTTCAATTCCTCATAGGTAATCTAAAATC	TTAAATGAAACAATAAAAGAGTATAATGAAACAAT
GTTTCAATTCCTCATAGGTAATCTAAAATC	CTGCTCTAAATGCAGTTACGTTAACAACAGATCAAA
GTTTCAATTCCTCATAGGTAATCTAAAATC	TAACTATTTTCAACCTGTTTGCTCTCAGTAAATTTA
GTTTCAATTCCTCATAGGTAATCTAAAATC	ATGAGAAAAGCTAACATAAAGAGCATAGATTTAACTTA
GTTTCAATTCCTCATAGGTAATCTAAAATC	AGGCAGTTACTCCTTTGAATTTAAAAACTGAATTAGA
GTTTCAATTCCTCATAGGTAATCTAAAATC	TACTAGGTTCCCTTTTTCTTTGCCTTGGGATTTATA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TGGTAGTTATACAATTCCTTTTTCTTTGGCTAAAGCCCT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	CAATATTTTTTCAAAACGCTCTTTTTGCTTAATCT
GTTTCAATTCATCATAGGTAGTCTAAAATC	TTGCTTGCATTTCCTGTATTATCCAAAGTTATAGCTT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TGTCACATCCATGATAGCCTGTTGTTCTTGAGGAG
GTTTCAATTCCTCATAGGTAGTCTAAAATC	CTGTGTAACTGCTATTGCTCCCGCATGATATTTTC
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TTTCATTGTCATTATTCATTTCCCTCCATTTTCTTTT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TTTCAAGATGAAGAATATGATTGGCATATCAAAGATGT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TGAAAATGGTAGAAAAAACATTTGAGACTTGTTCTAC
GTTTCAATTCCTCATAGGTAGTCTAAAATC	AGAAAAACTAGGAGCTAATGTCGGAGATACAGTGGAGG
GTTTCAATTCCTCATAGGTAGTCTAAAATC	GGACAAATTATTGCTATTACTAAGTTACAAGAATGTTA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TGAAAAGTGCTGTATTGCAGCAGTATCCTAAGAAAAA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TTTTTCTTACTCACATCATTTCCCTCCAATTCTTCTTT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	CTTAGTGGATTCTAAAGAAGGAAAAACACATTCCCTTT
GTTTCAATTCCTCATAGGTAGTCTAAAATC	AATCTTTTATTGTATAACTGTCCTTATGTATTATAA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TATAAGATAGCATTTCTTGTTTTGCACCATATCTAA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	CAGGAAAAGGAAAAGAAAGATATATGCTGGTTGATGA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TATTAAATCCAGATTGGACTTGCAGAGGTATGCAATA
GTTTCAATTCCTCATAGGTAGTCTAAAATC	TAGTCAGGAGGAATAAAGTATGATTTTTTTTAAAAG
GTTTCAATTCCTCATAGGTAGTCTAAAATC	GTATCCGCCTAACACGATTTTTCATTAATCAATGAGA
GTTTCAATTCCTCATAGGTAATCTAAAATC	AAATACGTTCTTTGATAGAAACGGAGAAGGTGCATCG
GTTTCAATTCCTCATAGGTAATCTAAAATC	TTAAAACGTGGAAAGGATGTAATATGTAATTTTCCTA
GTTTCAATTCCTCATAGGTAATCTAAAATC	CCAAGCCTTGAAGACTTAAAACAATCATTTCTTTTTT
GTTTCAATTCCTCATAGGTAATCTAAAATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018335.1\|WP_083585692.1\|2067887_2068562_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|273848
NZ_CP018335.1\|WP_012102036.1\|2076377_2076704_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP018335.1\|WP_073538691.1\|2068743_2069910_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	c2c9_V-U4	-	gnl\|CDD\|223747
NZ_CP018335.1\|WP_083585693.1\|2072383_2072875_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP018335.1\|WP_073538700.1\|2081579_2082254_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP018335.1\|WP_073538689.1\|2067050_2067809_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP018335.1\|WP_073538697.1\|2076994_2078245_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP018335.1\|WP_073538687.1\|2061916_2062672_+\|serine-protease	unknown	unknown	gnl\|CDD\|131955
NZ_CP018335.1\|WP_073538702.1\|2083322_2083706_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018335.1\|WP_073538696.1\|2075401_2076373_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018335.1\|WP_073538688.1\|2062895_2063999_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018335.1\|WP_073538694.1\|2071370_2072363_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NZ_CP018335.1\|WP_073538704.1\|2085069_2085765_-\|DUF3298-domain-containing-protein	unknown	unknown	gnl\|CDD\|378702
NZ_CP018335.1\|WP_073538703.1\|2083702_2084782_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|223609
NZ_CP018335.1\|WP_073538693.1\|2071104_2071368_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP018335.1\|WP_073538686.1\|2060102_2060816_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NZ_CP018335.1\|WP_073538701.1\|2082666_2083290_+\|LexA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NZ_CP018335.1\|WP_073538692.1\|2069902_2070511_-\|IS607-family-transposase	unknown	unknown	gnl\|CDD\|239738
NZ_CP018335.1\|WP_073538698.1\|2078251_2078947_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP018335.1\|WP_073538699.1\|2079014_2081555_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957

Protein	Function_ID	Function_description	E-value
NZ_CP018335.1\|WP_083585692.1\|2067887_2068562_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.00313e-35
NZ_CP018335.1\|WP_073538700.1\|2081579_2082254_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.53506e-114
NZ_CP018335.1\|WP_073538691.1\|2068743_2069910_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.19921e-35
NZ_CP018335.1\|WP_083585693.1\|2072383_2072875_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.55821e-69
NZ_CP018335.1\|WP_073538689.1\|2067050_2067809_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	3.85787e-21
NZ_CP018335.1\|WP_073538697.1\|2076994_2078245_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.00592e-42
NZ_CP018335.1\|WP_073538687.1\|2061916_2062672_+\|serine-protease	gnl\|CDD\|131955	TIGR02909, conserved_hypothetical_protein, uncharacterized protein, YkwD family. Members of this protein family represent a subset of those belonging to pfam00188 (SCP-like extracellular protein). Based on currently cuttoffs for this model, all member proteins are found in Bacteria capable of endospore formation. Members include a named but uncharacterized protein, YkwD of Bacillus subtilis. Only the C-terminal region is well-conserved and is included in the seed alignment for this model. Three members of this family have an N-terminal domain homologous to the spore coat assembly protein SafA.	3.53376e-72
NZ_CP018335.1\|WP_012102036.1\|2076377_2076704_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.30879e-16
NZ_CP018335.1\|WP_073538694.1\|2071370_2072363_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.55557e-161
NZ_CP018335.1\|WP_073538704.1\|2085069_2085765_-\|DUF3298-domain-containing-protein	gnl\|CDD\|378702	pfam11738, DUF3298, Protein of unknown function (DUF3298). This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.	4.1572e-11
NZ_CP018335.1\|WP_073538703.1\|2083702_2084782_-\|radical-SAM-protein	gnl\|CDD\|223609	COG0535, COG0535, Predicted Fe-S oxidoreductases [General function prediction only].	1.34804e-06
NZ_CP018335.1\|WP_073538693.1\|2071104_2071368_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.03327e-30
NZ_CP018335.1\|WP_073538686.1\|2060102_2060816_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	6.42314e-38
NZ_CP018335.1\|WP_073538701.1\|2082666_2083290_+\|LexA-family-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.69081e-14
NZ_CP018335.1\|WP_073538692.1\|2069902_2070511_-\|IS607-family-transposase	gnl\|CDD\|239738	cd03769, SR_IS607_transposase_like, Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.	3.43882e-47
NZ_CP018335.1\|WP_073538698.1\|2078251_2078947_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.82393e-78
NZ_CP018335.1\|WP_073538699.1\|2079014_2081555_-\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	1.91853e-14

>NZ_CP018335.1|WP_083585693.1|2072383_2072875_-|CRISPR-associated-protein-Cas4
MDINGVFLWYYNICKRELWLMSRKIVPDQQDENVDIGRFIHQNTYKRNKKEISFGNIKFDVIFRSKDNMVIGETKKSSKYKEASKWQLMFYLKTLKDAGIHASGQLLYPEERKREEVILDDTSSKELAEMISHIEYICSLDKPPGVKKIPYCKNCAYREYCFA
>NZ_CP018335.1|WP_073538694.1|2071370_2072363_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKDIYIFNDGELKRKENTIYFEGEDNKKHIPVEEIDTIWIFGEVTLNKRFLDFVSQKEICLHFFNYFGYYMGSFYPREHYNSGYVILKQCEFYLDFDKRINIARKIIQTAVENIIVVLKYYKSRGIELESEITDIFNKSKTMEGTESIEQLMALEGNIREKYYTCFNKIIKNEEFKFRGRSKRPPKDNINALISFGNSVMYSTVLGEIYHTHLDPRIGYLHSTNMRRFTLNLDIAEIFKPIMVDRCIFSLLNKNIITVKDFQEEFNGILLSESGKKKFLQEYNSKLYTTIKHPNLNKPVSYKRLIRMELYKIQKHITQDEEYVGFIARW
>NZ_CP018335.1|WP_073538693.1|2071104_2071368_-|CRISPR-associated-endonuclease-Cas2
MFVILVYDFGEKRVGKALKLCRRYLTWVQNSVFEGELSMANFKKLKIEIENIMDKKEDSVIIYKFNSTKYSKREQIGVVKNSQELFI
>NZ_CP018335.1|WP_073538692.1|2069902_2070511_-|IS607-family-transposase
MKKYPIGQFAKIINRSQQTLRNWDNANKLKPEYVDPKTGYRYYTDKQLKEFNGEVNKDNKIVVGYCRVSSSKQKEALERQIENVRIYLISKGYKFKIISDIGSGINYDKKGLNELIELILQNQVSKVVILYKDRLVRFGYELIKNICDYKNVEIEIIDNTEKTEEEEVVEDLVQIISVFSCRLQGKIANKTKKMIKELTEDD
>NZ_CP018335.1|WP_073538691.1|2068743_2069910_-|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MIRGIKVRLYPTKEQEILMWKSAGVARFTYNWGLAYLNSYYKENKKSLSIGELRKIFTELRNSEEYPWIREVSSEIPQQALKDLGDAFEEFFEDEHGYPKFKKKNKCENSFFHLNNKFVVKDKFIKLERIGFVKMKDEGRLPIGNYKKDKIKVTNPRIKHNGHHWYLSLGFEVENTHKLCLTGESIGVDLGIKELAVVSNIDKPFKNINKSKKVKKLNKRLLKLQRQISRKYDKLKSEKAFKKSEKPNKTNNIIKLEKKIKLLHKKISDIRLNHIHQTTNAIVKTKPSRVVVEDLNVTGLLKNKHLSKAIQEQSFNKFINTLEYKCEWNGIEFVKADRFYPSSKKCSCCGAIKKDLKLSDRIYKCACGIVIDRDKNASIDLANYKLVG
>NZ_CP018335.1|WP_083585692.1|2067887_2068562_-|CRISPR-associated-endoribonuclease-Cas6
MQAVILNWLGNENYQKFIHDCGFKFENRRYKLFTFSKIYGKFKIYRDKKIISFFDNANFTVSSLEDRFLNYLVLNVIAKDNFKFGNNIVGIEGIESAYSKLSEKEIVYTKSPIVVYSTFQNYQGNKTYYYNPLESEFSELIRRNLIHKYKAYYGAEPSDKCFSITPLYREKLKQRIVMYKGYVIKGWDGEFLIQGSKELMDIAYNAGIGSKNSQGFGCIEVKRK
>NZ_CP018335.1|WP_073538689.1|2067050_2067809_-|Fic-family-protein
MSYKDCIKVWRKGISEELLDRFFLKFTYSSNKIENNETRLRDVETIFKGKKVADFKGNKKTLVEIENHRELCKNIFKLCKKYDSKVSIDLAKKIHYALMKNCFSEQLLLKGESPGEFKKGDYIVGLHDVGVSPDEVEENLDSLFKEINEVKINDNNVLTVISYFHCWFENIHPFADGNGRTGRMLVNYLLIGNNFPPIVLFENDREQYYLALEYFNETQEISKMVDFLEDQAYKTWIKDYNIKLKNLKDFLD
>NZ_CP018335.1|WP_073538688.1|2062895_2063999_-|hypothetical-protein
MNTISNDQNTINWYNQSIQKILSSQVETSTNEDENKTESSIGSIGQAYRSSIFAGGTSNIINSLDNLVSNGTITEDQETIIQNAFNAAFKSNQTNSGTYNKVSNPLDNLVSSGIITQEQKTAIESNFKPDETKENNNVNPLDTLVSNGTITQEQENAVQSALESAFSENETQQKSDNGLTSTLDSLVSDGTITQAQEDAIKSAFESVFAQSHIQGRKDDGVDSVLDDLVSEGTITQEQKTAIQESFKSAFKSGKSEENNNINPLDSLVSSGIITQEQENAIQSAFENARTESESQEKGNNALTSVLDNLVSDNTISQDQEDAIKSAFESIFGQREKQGNSRIDSILDNLVSDGTITQEQEEAIQSIF
>NZ_CP018335.1|WP_073538687.1|2061916_2062672_+|serine-protease
MNKKIKLLIASLIIASGIPTVIPTMAKAASNTCSSPVVQQVSLKYDLNNYSQLKNCLKNYTVVTSKNACKNNNSTTKPTTNNNGTSTTKPTENTGNTGNTGNTGQTSTTTKPTENSGQTSTISAEANEVIRLVNVERSKNGLSPLKANAELSKVATAKAQDMIDNSYFSHTSPTYGSPFDMMKKFGISYTAAGENIAYGQKDAAEVMNSWMNSSGHRANILNSNFTEIGVGVAKDKNGTPYWVQMFINPGK
>NZ_CP018335.1|WP_073538686.1|2060102_2060816_-|type-1-glutamine-amidotransferase
MRIAEFIHDNDYPKLTNLDYWLKDNLNYETKKIVIDEHTRFSEIKDFDLIVLHGGIQHLWDKEQDPWLYKEIEYIKWALNNNKAVIGFCLGSQIIAEALGEMVYKAHKEEIGWFRVQLRAEAEEHILLKDLGQNFISFMCHSDHYDLPENCSSLAFTETAKNQIFVSNKFPTIGFQFHPEYTLKNIKVLLETFNDKDCFGEEYRLRKVNIIEQTKAFSSTYGLFKKLMDNSLKWFFK
>NZ_CP018335.1|WP_073538696.1|2075401_2076373_-|hypothetical-protein
METIKNYLDNVFAALPKTDELFKLKNDLLINMEEKYNELKSEKKSENEAIGIVISEFGNIDELIGELGVNLHEDEMNFPTITEEEVKNYMTMKKQTGILVGIGVFLCITGTALLILITTLVDEGIIGRGFSEDTGYMIGLITLFVMIVPAVALFIYSGMKSERYKYLKKGFNVPLSVKSLLQQRYNDFTSTYMVSLILGVCLCVLSPVSIFAASVFGDTASIYGVIILLIIIAIAVFIFIYYGSIKESFTFILRIDNFSKENVENNKVIGAVAAIIWPLAVCIFLVSGLVFDKWYINWIVFPITGILFGMFSSVYSIIKKRKN
>NZ_CP018335.1|WP_012102036.1|2076377_2076704_-|PadR-family-transcriptional-regulator
MISSDVIRGYNDIIILFMLLEDESYGYEISKNIRRLSEDKYIIKETTLYSTFNRLEKNKYIESFYKDETFGKRRTYYRITPLGRVYYKEKCREWDLTKEVINKFIKES
>NZ_CP018335.1|WP_073538697.1|2076994_2078245_-|HAMP-domain-containing-histidine-kinase
MILYYENPEIKRSSCIILILAIAFIAVNSFILHRGYEMVKKDYINNNVALIGKIVRIHPELEDEVVPIITKESSLKDVEFGIKILNKYDYKENLNINLLPGLKEDYSTLSKSMLFSMACFFIIVFLINSMEYVKMYRKLESLMFAAKNVIDYNFDVGIYENTEGIFARLAHTFNNMRAILKNNLIQIQKEKNFLINTLSDISHQIKTPISSLIIYNDILLNRKINEEKKIEFLRISQNQLNRIQWLVKSLLQLARLDVGAVRFEIKSNDINKTVTASIESLKIKSESANVKVEFYPEENEIMINHDPNWINEAIINIIKNAIEHTKPGGKVQVFTEKSQVCSRIIVKDNGEGIHREEIKHIFERFYKGRTNRSEESIGIGLALSKSIIEGNQGMINVKSKIGKGTTFEVVFLNRFI
>NZ_CP018335.1|WP_073538698.1|2078251_2078947_-|response-regulator-transcription-factor
MNKILLLEDDKALALGIEFTLIDEGYDVVKCSYAREAVEAFNSEVFDILVLDVMLPDGNGYDVCKYVRKKSQVPIIFLTACDEEVNVVLGLDIGADDYITKPFRVKEFVSRVKAILRRTESNNYKPKIFRCKDIVLNTETLEAYKRGHDLALSIQEYKLLLLFMNNAQRVMSREEILDNLTDGSGEYFDTNTLSVYIKRIREKIEQDSSSPEYIKTKRGFGYQWDIKVERE
>NZ_CP018335.1|WP_073538699.1|2079014_2081555_-|FtsX-like-permease-family-protein
MKSYKEITNKHLKHNKKRTVLTIFGIILSVALITSVGLFIKSLQNSFIESTIKSEGGFHVEISDISNEDYNELKNNAKIDTIGIQENWFECDVNGGKKIEIDKFDKNSLELLPDYYKAIKGRLPQKEGEIALENWIFKYMDNSTKIGDTVKLRTADGEIKNFKITGIIPNQIQTQYSGIALGMTYSNKFDMKRSTIYMTIYKSAGIRNTVDELSKKFKENCISNKHLLDYLGEGSSDLNKSLYSTAAIVIVIIIMATTAVIYNSFQISVMERIKQFGLLRAVGATPSQIRKIVLREASIISIVGIPLGLLGGIFAMFVVSKVFSIMSDTLFGTLKIVIPYYVLIISVLVGLAAVYISAFIPARSAGKVSPLAAISSRAYISKEKINRNRGRILKNFLNVESVMAFKNIKRNRKKFRVTVFSMVISIALFIFFSAFISMMQNFTEAPSESDKMHFQVIGIIDKSGDSSLKTDIINKIKKNNLVDKAYISYGTYKSNIFISDSEKNNYVDKNAPEIYKKVNFENQVMNSLDTVIDIYDKDKMTSIKDYIKDGKMDTDYMKQENGVIIVKNNIITVNKKYYNCAISNLKVGDSFYINKNMFYKGMTGEDYTEENNGSNLTNYNMVKAKVAAVVESEPYYFYNGDNRAFHIIMTKDVMKNITGKDTDNLPIKTADITLKDEKNEDKFNEFIQPLCDSNGVKLRDIVKINQSRRADSLQLLILMYGFIAVISFIGAVNIINTITTNLVLRRKEIASLNALGMTYENIRFMILTEGVLYGLYGAFYGGIVGSLLSYALSSPMRKIMDFTWTIPWNMIFISAIAAVFIGLISVIKPLSKIKKENIIDVIREED
>NZ_CP018335.1|WP_073538700.1|2081579_2082254_-|ABC-transporter-ATP-binding-protein
MGDILKVENLSKIYGEGENKVEALKNVSFTINRGEFIAIMGASGSGKSTLLHMIGGLDRPTDGKVYVDGEDIYKLNEQKLAIFRRRNIGFVFQFFNLIPVLDVEENISLPALLDKEKVDKNYLNEVIDMLGLKDRIGHLPSQLSGGQQQRVSIGRALINKPALILADEPTGNLDSKNGREVIELLKLSSKKYNQTLIVITHDMNVAEQAEKIITISDGEIKWNE
>NZ_CP018335.1|WP_073538701.1|2082666_2083290_+|LexA-family-transcriptional-regulator
MNFAMRLRELREENNLTQGAIASILNLTKANISKYELGRLQPNIETLKLLSDHFNVSIDYLIGVTNIKKVESNYLSRIPIFQITKNHPSLFIAENISGYEYFDKPQELSKNYFFFKIKDDSMSNARIFKDDLVCICKQDYIEDNKLMLIQVKNIGIILRRVLKCGDNLIILPENHKYNPIALSKKDLEEDSFKVIGKAVYVKFYIHE
>NZ_CP018335.1|WP_073538702.1|2083322_2083706_-|hypothetical-protein
MKIRMDFVTNSSSSSFILGVKDELTEEKILNMMKVPEDSLLRGLAEEFASIIYSNLSKFKLDEILEDYGCEDISELPDMYKKIIGNDEFIFYEGAVSDEISNIYSTLCHMDFDYEDENFIFYKEAGY
>NZ_CP018335.1|WP_073538703.1|2083702_2084782_-|radical-SAM-protein
MILKKFDKNYNFISIFNTENGFYMRTGILNDRGKDTGVEAFQSSFPELIDIGIMGHCIHGKSGLCLKAGVQCYQDGMNIQDENMSLENYITIINEIKGKTFQVALGGRGDPNKHENFGEILKYTRINNIVPNYTTSGFLLNETEVELTKKYCGAVAVSWYFHEYTTKAIDMFIHSGMKVNIHYVLNNKSIEEALYMLHNNSFPKGINAVIFLLHKPVGLGKEDKVLKCEDIPVKNFFSNIMSKKHSFKIGFDSCSVPALINFNNNFNIHSIDTCEAARWSMYITPDMKALPCSFDQKLKWSVELKNKSISDAWNSDIFESFRNKLKKSCPNCREKVNCMGGCPLCRSIILCNREEMYKL
>NZ_CP018335.1|WP_073538704.1|2085069_2085765_-|DUF3298-domain-containing-protein
MIYFRYPHKYKYPFEAEEPYYRNDTYKEDLKKSIKLQEQKLAPANFSIQYPFIDPLNCKGSGVDKVNNEIINQVSELFKKQVLQIGVVDFNEVLGNYEVMLNKNGILSILFSMYIYVNRAAHGSTLYSSMTANVKTGQIYSFSDLFNSKVYYKGFLDPLAKQYIKENNITLINEYNGITENQQFYLTPNSLVLYYQIYEYTPYYYGLFKIEIPYEKIVSILSPVGPINKLI

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Crispr_ID: NZ_CP018335_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018335_4

2659751-2660433

Orphan

III-B

Consensus_repeat	Method
ATTTAAATACAATCCTTGTTAAGGTTCAAC	CRT
ATTTAAATACAATCCTTGTTAAGGTTCAAC	PILER-CR
ATTTAAATACAATCCTTGTTAAGGTTCAAC	CRISPRCasFinder

10 spacers

The CRISPR arrays of NZ_CP018335_4

>merge|NZ_CP018335|4|2659751-2660433|CRT,PILER-CR,CRISPRCasFinder
CATCTGTTTCAAATCTTGTTAAGGTTGAACTATAAGAGCTACAAAAGATGTAAATGTTATTTGTTCATTTAAATACAATCCTTGTTAAGGTTCAACCAGATTGGGTTGTTGGCACTATTGCACATTTAGCCGCATTTAAATACAATCCTTGTTAAGGTTCAACGAAAGGAGGAAGAGAATGTCGAGAACTATAGCCAATTTAAATACAATCCTTGTTAAGGTTCAACACGTGGAGCAAACCGTCATTGTAAAATACTTGATACATTTAAATACAATCCTTGTTAAGGTTCAACTTGAAAACGGAAGGATATATAAAAATAGGAATACCATTTAAATACAATCCTTGTTAAGGTTCAACTATACCCACCTGGATAACATCCAGCACCTCTTCCAATTTAAATACAATCCTTGTTAAGGTTCAACAGTTTTATCAAAAAATCCAGAGACTTTTGTAGAAATTTAAATACAATCCTTGTTAAGGTTCAACTTTCCATATCTACAGGATGAACCAGAGTTATATCATTTAAATACAATCCTTGTTAAGGTTCAACAGCAGTTCAAGCCTCAAAGTAAATATATTACAAGTATTTAAATACAATCCTTGTTAAGGTTCAACCTAATGAATCCATAACAGCAACAATCACACTAAACAAATTTAAATACAATCCTTGTTAAGGTTCAAC

>NZ_CP018335|4|3|2659751-2660433|CRT
CATCTGTTTCAAATCTTGTTAAGGTTGAAC	TATAAGAGCTACAAAAGATGTAAATGTTATTTGTTC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	CAGATTGGGTTGTTGGCACTATTGCACATTTAGCCGC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	GAAAGGAGGAAGAGAATGTCGAGAACTATAGCCA
ATTTAAATACAATCCTTGTTAAGGTTCAAC	ACGTGGAGCAAACCGTCATTGTAAAATACTTGATAC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	TTGAAAACGGAAGGATATATAAAAATAGGAATACC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	TATACCCACCTGGATAACATCCAGCACCTCTTCCA
ATTTAAATACAATCCTTGTTAAGGTTCAAC	AGTTTTATCAAAAAATCCAGAGACTTTTGTAGAA
ATTTAAATACAATCCTTGTTAAGGTTCAAC	TTTCCATATCTACAGGATGAACCAGAGTTATATC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	AGCAGTTCAAGCCTCAAAGTAAATATATTACAAGT
ATTTAAATACAATCCTTGTTAAGGTTCAAC	CTAATGAATCCATAACAGCAACAATCACACTAAACAA
ATTTAAATACAATCCTTGTTAAGGTTCAAC

>NZ_CP018335|4|3|2659817-2660433|PILER-CR
ATTTAAATACAATCCTTGTTAAGGTTCAAC	CAGATTGGGTTGTTGGCACTATTGCACATTTAGCCGC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	GAAAGGAGGAAGAGAATGTCGAGAACTATAGCCA
ATTTAAATACAATCCTTGTTAAGGTTCAAC	ACGTGGAGCAAACCGTCATTGTAAAATACTTGATAC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	TTGAAAACGGAAGGATATATAAAAATAGGAATACC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	TATACCCACCTGGATAACATCCAGCACCTCTTCCA
ATTTAAATACAATCCTTGTTAAGGTTCAAC	AGTTTTATCAAAAAATCCAGAGACTTTTGTAGAA
ATTTAAATACAATCCTTGTTAAGGTTCAAC	TTTCCATATCTACAGGATGAACCAGAGTTATATC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	AGCAGTTCAAGCCTCAAAGTAAATATATTACAAGT
ATTTAAATACAATCCTTGTTAAGGTTCAAC	CTAATGAATCCATAACAGCAACAATCACACTAAACAA
ATTTAAATACAATCCTTGTTAAGGTTCAAC

>NZ_CP018335|4|4|2659817-2660433|CRISPRCasFinder
ATTTAAATACAATCCTTGTTAAGGTTCAAC	CAGATTGGGTTGTTGGCACTATTGCACATTTAGCCGC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	GAAAGGAGGAAGAGAATGTCGAGAACTATAGCCA
ATTTAAATACAATCCTTGTTAAGGTTCAAC	ACGTGGAGCAAACCGTCATTGTAAAATACTTGATAC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	TTGAAAACGGAAGGATATATAAAAATAGGAATACC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	TATACCCACCTGGATAACATCCAGCACCTCTTCCA
ATTTAAATACAATCCTTGTTAAGGTTCAAC	AGTTTTATCAAAAAATCCAGAGACTTTTGTAGAA
ATTTAAATACAATCCTTGTTAAGGTTCAAC	TTTCCATATCTACAGGATGAACCAGAGTTATATC
ATTTAAATACAATCCTTGTTAAGGTTCAAC	AGCAGTTCAAGCCTCAAAGTAAATATATTACAAGT
ATTTAAATACAATCCTTGTTAAGGTTCAAC	CTAATGAATCCATAACAGCAACAATCACACTAAACAA
ATTTAAATACAATCCTTGTTAAGGTTCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018335.1\|WP_156876046.1\|2650270_2650435_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018335.1\|WP_073539170.1\|2647756_2648422_+\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|197609
NZ_CP018335.1\|WP_073539184.1\|2664808_2665645_-\|DNA-adenine-methylase	unknown	unknown	gnl\|CDD\|273146
NZ_CP018335.1\|WP_073539185.1\|2667687_2669433_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP018335.1\|WP_073541323.1\|2666843_2667653_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293799
NZ_CP018335.1\|WP_073539173.1\|2649588_2650059_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_CP018335.1\|WP_083585720.1\|2671359_2672337_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NZ_CP018335.1\|WP_073539183.1\|2664045_2664729_-\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|132880
NZ_CP018335.1\|WP_073539189.1\|2675533_2676436_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP018335.1\|WP_073539179.1\|2656055_2659364_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|226581
NZ_CP018335.1\|WP_073539177.1\|2654454_2654967_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018335.1\|WP_073539186.1\|2669410_2671192_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP018335.1\|WP_073539175.1\|2651649_2652861_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341205
NZ_CP018335.1\|WP_073539176.1\|2652862_2654356_-\|SAM-dependent-DNA-methyltransferase	unknown	unknown	gnl\|CDD\|223363
NZ_CP018335.1\|WP_073539181.1\|2661429_2662332_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|274946
NZ_CP018335.1\|WP_073539188.1\|2672872_2674657_+\|DUF2207-domain-containing-protein	unknown	unknown	gnl\|CDD\|378333
NZ_CP018335.1\|WP_073539180.1\|2660952_2661405_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP018335.1\|WP_073539178.1\|2654959_2655940_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379114
NZ_CP018335.1\|WP_073539172.1\|2648896_2649592_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379219
NZ_CP018335.1\|WP_073539174.1\|2650622_2651597_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP018335.1\|WP_083585720.1\|2671359_2672337_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	4.87569e-21
NZ_CP018335.1\|WP_073539170.1\|2647756_2648422_+\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|197609	smart00257, LysM, Lysin motif.	2.15793e-13
NZ_CP018335.1\|WP_073539185.1\|2667687_2669433_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.61026e-129
NZ_CP018335.1\|WP_073541323.1\|2666843_2667653_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293799	cd07713, DHPS-like_MBL-fold, Methanocaldococcus jannaschii dihydropteroate synthase, Thermoanaerobacter tengcongensis Tflp, and related proteins; MBL-fold metallo hydrolase domain. This subgroup includes Methanocaldococcus jannaschii 7,8-dihydropterin-6-methyl-4-(beta-D-ribofuranosyl)-aminobenzene-5'-phosphate synthase (EC 2.5.1.15), a folate biosynthetic enzyme also known as dihydropteroate synthase and 7,8 dihydropteroate synthase. Thermoanaerobacter tengcongensis Tflp is a ferredoxin-like member. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	2.62455e-95
NZ_CP018335.1\|WP_073539175.1\|2651649_2652861_-\|hypothetical-protein	gnl\|CDD\|341205	cd17524, RMtype1_S_EcoUTORF5051P-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Escherichia coli UTI89 S subunit (S.EcoUTORF5051P) TRD2-CR2 and Archaeoglobus fulgidus VC-16 S subunit (S.AfuORF1715P) TRD2-CR2. Escherichia coli UTI89 S subunit (S.EcoUTORF5051P) recognizes 5'... CCANNNNNNNCTTC ... 3' and the recognition sequence of Archaeoglobus fulgidus VC-16 S subunit (S.AfuORF1715P) is undetermined. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It also includes TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases, such as Pseudomonas putida Jo 4-731 Type IIG restriction enzyme/N6-adenine DNA methyltransferase (RM.PpiI), and type I DNA methyltransferases such as Bacillus cereus BDRD-ST24 M subunit of Type I N6-adenine DNA methyltransferase (M.Bce24ORF51270P). RM.PpiI recognizes 5' ... GAACNNNNNCTC ... 3'.	1.84674e-81
NZ_CP018335.1\|WP_073539183.1\|2664045_2664729_-\|DNA-alkylation-repair-protein	gnl\|CDD\|132880	cd06561, AlkD_like, A new structural DNA glycosylase. This domain represents a new and uncharacterized structural superfamily of DNA glycosylases that form an alpha-alpha superhelix fold that are not belong to the identified five structural DNA glycosylase superfamilies (UDG, AAG/MNPG, MutM/Fpg and helix-hairpin-helix). DNA glycosylases removing alkylated base residues have been identified in all organisms investigated and may be universally present in nature. DNA glycosylases catalyze the first step in Base Excision Repair (BER) pathway by cleaving damaged DNA bases within double strand DNA to produce an abasic site. The resulting abasic site is further processed by AP endonuclease, phosphodiesterase, DNA polymerases, and DNA ligase functions to restore the DNA to an undamaged state. All glycosylase examined to date utilize a similar strategy for binding DNA and base flipping despite their structural diversity.	3.35389e-46
NZ_CP018335.1\|WP_073539189.1\|2675533_2676436_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	7.46018e-31
NZ_CP018335.1\|WP_073539179.1\|2656055_2659364_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|226581	COG4096, HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	4.32194e-175
NZ_CP018335.1\|WP_073539172.1\|2648896_2649592_-\|hypothetical-protein	gnl\|CDD\|379219	pfam13490, zf-HC2, Putative zinc-finger. This is a putative zinc-finger found in some anti-sigma factor proteins.	1.65087e-08
NZ_CP018335.1\|WP_073539186.1\|2669410_2671192_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.54719e-132
NZ_CP018335.1\|WP_073539173.1\|2649588_2650059_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	3.74482e-30
NZ_CP018335.1\|WP_073539176.1\|2652862_2654356_-\|SAM-dependent-DNA-methyltransferase	gnl\|CDD\|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	6.93834e-57
NZ_CP018335.1\|WP_073539184.1\|2664808_2665645_-\|DNA-adenine-methylase	gnl\|CDD\|273146	TIGR00571, DNA_adenine_methylase, DNA adenine methylase (dam). All proteins in this family for which functions are known are DNA-adenine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The DNA adenine methylase (dam) of E. coli and related species is instrumental in distinguishing the newly synthesized strand during DNA replication for methylation-directed mismatch repair. This family includes several phage methylases and a number of different restriction enzyme chromosomal site-specific modification systems. [DNA metabolism, DNA replication, recombination, and repair].	1.78546e-101
NZ_CP018335.1\|WP_073539180.1\|2660952_2661405_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.29692e-08
NZ_CP018335.1\|WP_073539178.1\|2654959_2655940_-\|ATP-binding-protein	gnl\|CDD\|379114	pfam13304, AAA_21, AAA domain, putative AbiEii toxin, Type IV TA system. Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.	1.00303e-09
NZ_CP018335.1\|WP_073539181.1\|2661429_2662332_+\|radical-SAM-protein	gnl\|CDD\|274946	TIGR04054, rSAM_NirJ1, putative heme d1 biosynthesis radical SAM protein NirJ1. Members of this radical SAM protein subfamily, designated NirJ1, occur in genomic contexts with a paralog NirJ2 and with other nitrite reductase operon genes associated with heme d1 biosynthesis, as in Heliobacillus mobilis and Heliophilum fasciatum. NirJ1 is presumed by bioinformatics analysis (Xiong, et al.) to be a heme d1 biosynthesis protein by context, perhaps involved in conversions of acetate groups to methyl groups in conversion from uroporphyrinogen III. A very closely related protein, involved in alternative heme b biosynthesis, occurs in Desulfovibrio and in methanogens. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	7.26635e-11
NZ_CP018335.1\|WP_073539188.1\|2672872_2674657_+\|DUF2207-domain-containing-protein	gnl\|CDD\|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	2.28093e-86

>NZ_CP018335.1|WP_073539179.1|2656055_2659364_-|DEAD/DEAH-box-helicase
MSNFSFLNRKWPVLAKLGIQAENYLHTDNNATMLKMRMFGEKIIDYILAMYKVEAGRFATQDDKIKLLRTTNINKAIPDLFDIVRRFGNKANHDGYENKKYALECLVSMYKIAAWLYIRITKDTSIKPLTYKIPKPKAAGNKVYGMDDYVREKEKIKEDHTKEIKDVKKQADGLVQTEEDKKVQKEVESTLEFNEAQTRKKLIDIMLKDAGWYLNDKELVKVELPLGDHKGKGKTGYADYVLFNRKGKPVAVVEAKKTSVDPIIGRQQAVEYANSIEKIYKARPVIFYTNGYEIYMWDDNYSEPRQIWGFYTLEDLEELFFKHRHKKDLNKIKIDKNISGRPYQIEGIKRVYEKYENGKRKALLVMATGTGKTRTVIALTKGLMEANWVKRVLFLADRDELVKQAKEDKNSFKTFMPEEISCRFTGKNSDNREATLYFSTYQTMINYYREFSVGFFDLIICDESHRSIYKVYRDILEYFDSHIIGLTATPVDFIERNTFNLFNCDNGDPTFNFPIEDAWNHVPPYLIEPRVIDTTTDFLRKGIKYNEMTEEQRQQIEEEGYDGDEINYDKKELEKKITNKDTNRYILRTLMEKGIKVGDYIGKTIIFAKNKKHANLLDLLFNELYPQYKGKLTAVIYSDIKDKSVLIEKFKGEDFPRIAISIDLLDTGVDVPEIVNLVFAKPVYSKVKFWQMIGRGTRRCENLYGEGWDKKEFPIFDCYKNFEFFEIHAKGYEPKPQKTSIQKRFQIMCSLLEKFKEKGELDICKAFAAKLKADIEELPEDSIEIKKNRKKVEQVKREEYWNNLSEDFIKKLKLEIAPLTKWIESKDNSDAVGFDNSIYRIMINNISNDKDNLVKEINDMIKKLSRLKLNLNQFDGERELVKSLLQPFGWQDLSYERLEKIRVSLRELVKYKGEVSNTFIVLDIKDTGSITKEISAASVLYGGNMEPYEKRVRLAIENKLKDQIVIHKIRKGEKLSQEEIQSIYSIFGEDFIYSIDELSTKTDIDKEDIIGIIRKFIGIDEVELNKRFENFIQKHHNKMNSTQIKTLEIIKNDIAKNRGISFAALFAEPYTNFNQNGVDGIFGKMADDVFELIAPFRAWYIS
>NZ_CP018335.1|WP_073539178.1|2654959_2655940_-|ATP-binding-protein
MYIEKINVKNFTVFENLEIDFCRGINILIGENGTGKTHLMKLMYAPLAKRNSRSMVFWEDVFTHNTGVQTVPDYFRRNKHQKFFIKILFNRDKPYENKDGILSQKFYDVSTVFIPAVEMLSHSKGFLALERERSIPFDRTLIDIIAKAELGESKKVSDLNKNILKTLSDVIDGKVIYENDTFFILKKNGLKVEFSMEAEGIRKIGLLWKLIRNGIINRDSILFWDEPEANINPQLIPQIVKILLELQRNGVQIFLATHDYNLAKYFEVLSKDNDEVVYYSLYKTDNGVQCAKAQIYREIYNNAIEDANERLYNDILDKAAQEAEDE
>NZ_CP018335.1|WP_073539177.1|2654454_2654967_-|hypothetical-protein
MNSSYMKEGRFRFDFSSAISKYKPDDCTLNGLGGVDFVVELEDKFLFIELKDIENNKVPREQKKEWIERLKVRKENLFLMDLGVKFKDTLIRRWAKEENFDKPIWYLIIIEFKEMDAAQKIKLSEDLSGKLPTCIKAKFGFKKEIKIKQRMILSIEDWIEKFPQFQVTEI
>NZ_CP018335.1|WP_073539176.1|2652862_2654356_-|SAM-dependent-DNA-methyltransferase
MLNSEIKSKIDKLWNNFWSGGISNPLTVIEQISYLLFIKRLDDIDSSKEKMVNRIGKLYISIFPEELMKWSNFRHLDVNEMFDMVSQKVFPFIKNMGGEDSSFTAEMKDAVFMIPKTSLLQESVRIIDGINMEDADTKGDLYEYLLSKLLVSGVNGQFRTPRHIIRMMVELDPTAEDRICDPACGTAGFLINSLEYILEKYTKHESVFTDDEGIVHKRIGDMMSSQDWEHFRTSMFYGFDFDPSMVRIASMNLMLHSIDNPNVVQSDSLSKRYEEQNRYTLVLGNPPFKGSIDKEDISKSLVKGAGTTKTELLFIKLINRILDLGGRCAVIVPDGVLFGSTKVHKEIRKDLVENNRLEGIISMPSGVFKPYAGVSTAILMFIKGGETDRVWFYDMTADGFSLDDKRNPIDNSDIPDIIKSFKKVKKDDKLEPDKEDKWFWVEKEEIADNDYDLSINKYKEIEYEEVEYEKPQVILERIEALEKEILSDIAELKGMVK
>NZ_CP018335.1|WP_073539175.1|2651649_2652861_-|hypothetical-protein
MKERRLPEGWKVEKLGSLLRIDGGFAFKSDRFTKNAVPIVRIGNIVDGNIELDYNTCYKVNNSEFERYYVNHGDILIAMSGATTGKLAMYRDNQRCLFNQRVGRFYVYDKEKLDNGYLYYYLKSGSVQNKIRVMASGCAQPNISPDQILSIKVLVPLLQSQKKIVQVLEKAEKALEKKKEAIRLLNDLIKSRFIEMFGDPVKNTKGWPKGRIVDVIVKTQYGTGNKADEQNGKYKILRMNNITYNGEWDFSSMKYVDLDEKDQEKYLVSKGEVLFNRTNSKELVGKTAVYKEQEPMAYAGYLVKAIPNEKANGVFIATYMNTKYIKSKLFNMAKNIVGMANINAEEFKKIDIYIPPIELQNQFADFINQVDKLKFKMEESLKELENLFNSLMQKAFRGELEFN
>NZ_CP018335.1|WP_073539174.1|2650622_2651597_-|hypothetical-protein
MDKLIFNDKEFIYYEYINEAEFERYIVENANKIFGEKSIYVDIKKRIGDSILSIPDGYLLDFSFVNEPKLYIIENELVTHDPYKHIGQQILKFAISYKASGRKIKRFLLEEIQKNKYYLELVNDFIEKAKYRNIDNLIEEMVFGEVGCIVVIDQNTYELENVLSQITMKTDIVEFQTFVNKEGEKIFKFQPFQEDIKADIDTKTELSADDLDTIVVPAREEGFNEVFLGEDCWYAIRMSSSMLERVKYIAAYQSAPISAITYYAEVSKIERYENTNKYIVCFKDKAIKIQDIKLPKNNHKLAPQSPRYTNFRKLINAKSLDEIF
>NZ_CP018335.1|WP_156876046.1|2650270_2650435_+|hypothetical-protein
MKCRNGSWPKPDIVSTEDGNGYIDMEVDRSDIPFLSEYFFHLRTDAKIIVPSLP
>NZ_CP018335.1|WP_073539173.1|2649588_2650059_-|sigma-70-family-RNA-polymerase-sigma-factor
MTDFEVIYSQYFADVYKYALSLCRNETLAEEITQETFFKALKSIDKFKGDCKMRVWLCQIAKNTCFSIYQKNKHITDEFHEEDEGECIEQKLINSEIAWEIHKILHFLDEPYKEVFTLRVFGELSFLQIAELFEKTESWARVTFHRAKIKVKGRLK
>NZ_CP018335.1|WP_073539172.1|2648896_2649592_-|hypothetical-protein
MKISCEIVKDLLPLYHDNICSKESRTIVEEHLLECDTCQKYLDDMNSNFIKTNAEKSAEQVKSDILKGIKKKLLRKNLIISAVSVICAIAVLLGAFLLIFHYQMPIPYENGLVSVKMGDNGMLDIYFNGDDYYCSYEWNATIEKDGIKQHIAYIYYTDTIWTKHFSKPQKDKQYKYSINNSTFFNYDNDNEFIEVKKEISAVYYLDYSHIPKLSTKELQKNSSKAVLLWKK
>NZ_CP018335.1|WP_073539170.1|2647756_2648422_+|LysM-peptidoglycan-binding-domain-containing-protein
MPYNYYRQCPANHYPYVIQPGDTLYNISRRLEVSIQRIIASNPGINPYYLKVGQIICIPACPPNYTSRIIQPGDTLYKISREYNVSVESILDANPGIDPNYLRVGQRLCIPPSNSESENCEKTTSAMQDDIDVLKNESTVQKTHESNYRNSTQTTTTATVTERQIRFNAVNVAFSGNYSGHYTSGKSYPYYADASSGGQRGINVRDNFGVWHSFNYRVPLT
>NZ_CP018335.1|WP_073539180.1|2660952_2661405_+|helix-turn-helix-transcriptional-regulator
MTREEFIKIVDSKIKLLRNEKNYTQDKMADMLGISKKTLVQIEKGRHSLGWTTAVAACTIFKDSEILQLAFGDDTEDIILTLAFDSYDNKTYEKTLGGHIWWKDIELKGNYKIQQNIISKHYRILNNKNMRICSSFDFDYIQERLKELGK
>NZ_CP018335.1|WP_073539181.1|2661429_2662332_+|radical-SAM-protein
MKVKSFLSLAIFGIKTILFKMEKPILGGIILTDYCNLNCKRCAVNNINKIIYSYRDILEEMNNLYNEGIRILLFYGGETLIWEDHNKTIHDLIKEAKQIGFLIVNIVTNGTIDLDIPYADTIFLSLDGIKESHNFIRGNTFDTILHNVSKATSSNICVYMAVNNVNYKDIEPLCKLVKKTPNLKSISFNFHTPYKGTEWLCLTNHQKVKAVNSIKSMIKEGYPVFNLYSALDHYLEDNWKRPCYQCIVSENKRRFTCGRCIEVEGLCKKCGYLFAIEFSLLCRGNIRVIIDMIKTYLKYI
>NZ_CP018335.1|WP_073539183.1|2664045_2664729_-|DNA-alkylation-repair-protein
MNQKIRQKIFELSDEKYKEFHNKLSPTGSNIIGVRMPLLRKLAREIAKGDWREYLKTAESKYYEEIMLQGIVIGCVKVDVEERLQLIRGFIPKIDGWGICDSFCNGLKFIKSNKERVWNFIQPYLKSNHEFYVRFGVVVLLDFYIDETYINRVLDTLDEIKHPGYYVKMAVAWTVSICYIKFPEITMTYLKNNSLDDFTYNKSLQKITESLRIDNETKLVIKNMKRR
>NZ_CP018335.1|WP_073539184.1|2664808_2665645_-|DNA-adenine-methylase
MKYDKLVEPVVKWAGGKRQLLPELKKYIPKNISTYYEPFLGGAAVLFDIQPKKAVVSDINEELINLYMAIRDNVDELIEDLKEHKNTPDYFYKIRGLDRETSIYSKLTKVERASRIHYLNKTCYNGLFRVNMAGQFNSPFGNYKNPNITNEITIRAVSKYLNEANIKLKCCDYEETLKSIRKGAFIYFDPPYDPVSNSSNFTGYAKEGFNRDEQWRLRSVCDKLNSKGIKFLLSNSSTDFILDLYKDYNIKIIQAKRFINSNGNKRGEINEVLVRNYE
>NZ_CP018335.1|WP_073541323.1|2666843_2667653_-|MBL-fold-metallo-hydrolase
MKLKVLVDNNTYIDEYYYGEPSVCYYIEDEDTRLLFDVGYSDIFLKNSTALGVDLKNIDTIVISHRHDDHTGGLKYYFQQNYRNNISIIAHTDAFKEKTVESFRICSPMLKKELKKKCNLILSKKPKKVSKNITFLGEMPRTNNFENTKPIGKQSFGEISIDDYSMDDTALVYKGEKGIYIITGCSYSGICNIAEYAKKVCGDNRMFGIIGGLHLFEVNSQAVRTIEYLKKNNIKELYPCHCTSFQVKAEMYKSLPIGEVGVGMEINWQ
>NZ_CP018335.1|WP_073539185.1|2667687_2669433_-|ABC-transporter-ATP-binding-protein
MFKVKLIEKLQHKYALSEKGAKDMIKAFGACTLSNIVLMLPIALLYYLVRDLMNNNIDGKYTVFYVIGSIVCLLLIFITTYLQYNATFFATYVESGVRRISLAEKLRKLPLSFFGKKDLSDLTSTIMADCSLLETASSHWIPELIGSIISTFIIAVSLFFFDWRMAIAAFWVLPVSFIIVLFSSKVQYTLGKKQMKVKMDCADGIQECLESVRDLKSNNAETAYMRGLDVKIKNVEKRALITELGTAAFVASSQMVLKLGIATVALAGGIFLVDGSLDVLTFFMFLLLVSRLYDPMQMSLQNLAAIISSNIQCERMDEILGHEVQTGLERLTNKGCDIVFDHVAFAYNNNETVLRDVSFTARQGEVTALIGPSGGGKTTVSRLAARFWDISKGRITVGGMDISKIDPEALMYLYSIVFQDVTLFNNSIIENIRIGRKNASDEEVIQAARLAHCDEFAEKLPEGWNTMIGENGSELSGGERQRISIARAFLKDAPIILLDEATASLDVENETMIQESLSRLIQNKTVLIIAHRMRTVAGADKIVVLKDGVVAEQGTHDKLVKKGGIYKHMTEMQLEAASWRF
>NZ_CP018335.1|WP_073539186.1|2669410_2671192_-|ABC-transporter-ATP-binding-protein
MKKKSNMSKLFGYAGSFKYLTIASWVLSAVSAFVALVPFVYIWEIIKEVLKVAPDFSAADNLTHYGVMAVIFSVLSMLIYIVALMSSHIAAFRVQANIRSQAMHHIITLPLGFMDGVGSGKIRKIVDESSAATETYLAHQLPDRAGALATPVGLLAMLLVFDWRLGLLSLIPIVIAFCIMSVMTGSRMQQKMKEYQNSLEQMSNEAVEYVRGIPVVKTFGQSVFSFKRFKTSIDNYEKWVISYTKDLRLPMMFYTTAINAVFAVLIAAALFFTSNGVTSEFLLNLLFYIIITPIITVTLNKIMYSSENMMIVEDALERIDSVMAMKPLQENAVPEHPKDNSVSLHGVSFRYKDAKENALNNISLKIDPGEHVAFVGPSGGGKTTLASIIARFWDVDSGEVAIGGVNVKDISKEELMNTVSFVFQESRLLKTSILENVRLAKPNATREEVLKALKDARCEDIIEKLTDGMDTIIGTNGNYLSGGEGQRVSIARAMLKNAPILILDEATAFADPDNESKVQAAFSTLSKGKTVLMIAHRLSTVTGADRIYVIEDGKICESGNHHELTQQAGLYTHMWNEYNSAAKWKVGVQSEVN
>NZ_CP018335.1|WP_083585720.1|2671359_2672337_-|helix-turn-helix-transcriptional-regulator
MRGNSRMRATHRDKQLYGNQVDIIRRDDDCTIYRINNSKGYVVMTSYSVFPGIELIYNDVHTQWVSVDIDPPKNILEINHCREGIIECESKKGDYLYLSKGNLAINFKNSTSNSSNFPLNHFHGITVAVDFDKIHGYLSCILEEVSVNLSGLKSKFCENSREFLVIRENQSIEHIFSELYAVSEKIRKGYYKVKVLELLLFLSSLEQEELKQSKKYYSKRQVNIIKEIKKYLTIRLSEKITLDQLSIQFKIPLTTMKLIFKEVYGKSIYSFIRTYKMQKAAELLKNTDKEINEIAASLGYDNASKFSEAFKKVIGVNPSVYRKNV
>NZ_CP018335.1|WP_073539188.1|2672872_2674657_+|DUF2207-domain-containing-protein
MKKFLLGLFVLFFIISVNPLNVSASSEEIALSKFNIETTIKEDGSIDMVELITYNFKKKFNGAYRDISIRNTEGIYDIKVSFISEAGQETPFRKVTDAKNGDNNVFEISKQNKDLYRLKIYSPSKNEEKTFKIAYTMKNVVTKYKDTGELFYEYWSDYNETKIDNLKIHINLPYNMENQDIKAYYHTVSSGNISVKNGTVEYTFPHINSKELVEARVLFPASSIPLSPKTRNENALDRILSEEADYREKQQQKIALALARKKTFNYVSIISVLFFLIFILIIWRKFRNNNQDVYSIYSPPELPEECTPAVAAYLVNRTATGRTIYATLLDLWRKGYLTIKKAEPENKKDKINFSINKVEKDSGELLNHERYFMNWLFDKLGNGKSVTTSSIKKANKKSPFYHDSQEWSNLIREEVKSRNYYDKKANRTGIWLIAFSIIGIIISIVSLAFGAGMGILSLLASVITMICGVYYCVKKSPKGQSRYNNWIKFIKYIKNTDFTCDLNTHYIESYIPYAEALNIKKGSMSNLTAAFHNPSQNMGWIYYYLLFDSMNLNRKEQFSYYIYDSFNTGSSGSSSSDSSSSSSGSSGGGGAGGF
>NZ_CP018335.1|WP_073539189.1|2675533_2676436_-|HAMP-domain-containing-histidine-kinase
MIYIVCILSVVTILCLIKYYFTKINIHALIAQTNRLNRLISESNEQIKVVAPDKTTEKLAIEINHLVDCYKTLQLKNIKEKQQYKKILANFSHDLRTPLTSIMGYIDIILHLELSEKDKEKYLETVQYKLKTLNNLVDSLYDLSLIDAKEYPVQLNPHSVYQLLCDSLLLFHQDFEDKSISLQLNLDEKVPLVLLDEKITNRVLLNLLQNVIRYAKSYCKVDLGVTYEYVNISISNDCEPLSEEDVLQLFNRTYKADSNRSKHSSGLGLAIAKELMELQLSNINADYHDNTLTFMLRFKR

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Crispr_ID: NZ_CP018335_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018335_5

4116265-4116555

Orphan

III-B

Consensus_repeat	Method
CATTTAAATACAAATCTTGTTAAGGTTCAAC	CRISPRCasFinder
CATTTAAATACAAATCTTGTTAAGGTTCAACT	CRT
TCATTTAAATACAAATCTTGTTAAGGTTCAAC	PILER-CR

4 spacers

The CRISPR arrays of NZ_CP018335_5

>merge|NZ_CP018335|5|4116265-4116555|CRISPRCasFinder,CRT,PILER-CR
TATTTTAATACAATCCTTGTTAAGGTTCAACTTCTAATGGTAGATCAACTTCTCTTATCCTTTCTTCATTTAAATACAAATCTTGTTAAGGTTCAACGTGCGAATGTATGTGCCACTGTTAGACGTTCCACATTTAAATACAAATCTTGTTAAGGTTCAACTATTTCAGAACCATCATTTCTGGTTTGTATACATCATTTAAATACAAATCTTGTTAAGGTTCAACTCTACTATTTGTTTTTTAGTAGTTCCTCTTCCTCATTTAAATACAAATCTTGTTAAGGTTCAACT

>NZ_CP018335|5|5|4116265-4116554|CRISPRCasFinder
TATTTTAATACAATCCTTGTTAAGGTTCAAC	TTCTAATGGTAGATCAACTTCTCTTATCCTTTCTT
CATTTAAATACAAATCTTGTTAAGGTTCAAC	GTGCGAATGTATGTGCCACTGTTAGACGTTCCA
CATTTAAATACAAATCTTGTTAAGGTTCAAC	TATTTCAGAACCATCATTTCTGGTTTGTATACAT
CATTTAAATACAAATCTTGTTAAGGTTCAAC	TCTACTATTTGTTTTTTAGTAGTTCCTCTTCCT
CATTTAAATACAAATCTTGTTAAGGTTCAAC

>NZ_CP018335|5|4|4116265-4116555|CRT
TATTTTAATACAATCCTTGTTAAGGTTCAACT	TCTAATGGTAGATCAACTTCTCTTATCCTTTCTT
CATTTAAATACAAATCTTGTTAAGGTTCAACG	TGCGAATGTATGTGCCACTGTTAGACGTTCCA
CATTTAAATACAAATCTTGTTAAGGTTCAACT	ATTTCAGAACCATCATTTCTGGTTTGTATACAT
CATTTAAATACAAATCTTGTTAAGGTTCAACT	CTACTATTTGTTTTTTAGTAGTTCCTCTTCCT
CATTTAAATACAAATCTTGTTAAGGTTCAACT

>NZ_CP018335|5|4|4116330-4116554|PILER-CR
TCATTTAAATACAAATCTTGTTAAGGTTCAAC	GTGCGAATGTATGTGCCACTGTTAGACGTTCC
ACATTTAAATACAAATCTTGTTAAGGTTCAAC	TATTTCAGAACCATCATTTCTGGTTTGTATACA
TCATTTAAATACAAATCTTGTTAAGGTTCAAC	TCTACTATTTGTTTTTTAGTAGTTCCTCTTCC
TCATTTAAATACAAATCTTGTTAAGGTTCAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018335.1\|WP_073540411.1\|4115044_4115239_-\|alpha/beta-type-small-acid-soluble-spore-protein	unknown	unknown	gnl\|CDD\|365990
NZ_CP018335.1\|WP_073540418.1\|4123922_4124783_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP018335.1\|WP_073540414.1\|4118846_4119986_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018335.1\|WP_073540417.1\|4122502_4123708_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NZ_CP018335.1\|WP_073540427.1\|4130824_4131175_-\|DUF1048-domain-containing-protein	unknown	unknown	gnl\|CDD\|368835
NZ_CP018335.1\|WP_073540420.1\|4125549_4128450_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223989
NZ_CP018335.1\|WP_073540415.1\|4120544_4120865_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367272
NZ_CP018335.1\|WP_073540409.1\|4112999_4113977_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP018335.1\|WP_073540422.1\|4128529_4128916_-\|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|239517
NZ_CP018335.1\|WP_073540424.1\|4129279_4130050_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912
NZ_CP018335.1\|WP_156876112.1\|4117512_4118762_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|366234
NZ_CP018335.1\|WP_073540407.1\|4111627_4112113_-\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NZ_CP018335.1\|WP_073540403.1\|4106036_4107473_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP018335.1\|WP_083585786.1\|4112176_4113046_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP018335.1\|WP_073540405.1\|4108350_4109022_+\|lactate-utilization-protein	unknown	unknown	gnl\|CDD\|376839
NZ_CP018335.1\|WP_073540410.1\|4114597_4114960_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NZ_CP018335.1\|WP_073540425.1\|4130050_4130809_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213232
NZ_CP018335.1\|WP_073540406.1\|4109482_4110844_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP018335.1\|WP_073540404.1\|4107557_4108214_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NZ_CP018335.1\|WP_073540412.1\|4115361_4115745_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP018335.1\|WP_073540411.1\|4115044_4115239_-\|alpha/beta-type-small-acid-soluble-spore-protein	gnl\|CDD\|365990	pfam00269, SASP, Small, acid-soluble spore proteins, alpha/beta type.	2.92775e-30
NZ_CP018335.1\|WP_073540418.1\|4123922_4124783_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.37088e-48
NZ_CP018335.1\|WP_073540417.1\|4122502_4123708_-\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.3692e-75
NZ_CP018335.1\|WP_073540427.1\|4130824_4131175_-\|DUF1048-domain-containing-protein	gnl\|CDD\|368835	pfam06304, DUF1048, Protein of unknown function (DUF1048). This family consists of several hypothetical bacterial proteins of unknown function.	9.09382e-46
NZ_CP018335.1\|WP_073540420.1\|4125549_4128450_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	7.04446e-77
NZ_CP018335.1\|WP_073540415.1\|4120544_4120865_-\|hypothetical-protein	gnl\|CDD\|367272	pfam02956, TT_ORF1, TT viral orf 1. TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF1 is a large 750 residue protein. The N-terminal half of this protein corresponds to the capsid protein.	0.000224288
NZ_CP018335.1\|WP_073540409.1\|4112999_4113977_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	4.36097e-14
NZ_CP018335.1\|WP_073540422.1\|4128529_4128916_-\|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase	gnl\|CDD\|239517	cd03425, MutT_pyrophosphohydrolase, The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). This enzyme requires two divalent cations for activity; one coordinates the phosphoryl groups of the NTP/dNTP substrate, and the other coordinates to the enzyme. It also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as metal binding and catalytic site. MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides.	8.27597e-50
NZ_CP018335.1\|WP_073540424.1\|4129279_4130050_-\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	9.06448e-11
NZ_CP018335.1\|WP_156876112.1\|4117512_4118762_-\|IS3-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	1.10789e-20
NZ_CP018335.1\|WP_073540407.1\|4111627_4112113_-\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	3.10338e-67
NZ_CP018335.1\|WP_073540403.1\|4106036_4107473_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.83637e-41
NZ_CP018335.1\|WP_083585786.1\|4112176_4113046_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	4.81718e-22
NZ_CP018335.1\|WP_073540405.1\|4108350_4109022_+\|lactate-utilization-protein	gnl\|CDD\|376839	pfam02589, LUD_dom, LUD domain. This entry represents a domain found in lactate utilization proteins B (LutB) and C (LutC), as well as several uncharacterized proteins. LutB and LutC are encoded by th conserved LutABC operon in bacteria. They are involved in lactate utilization and is implicated in the oxidative conversion of L-lactate into pyruvate.	4.95853e-54
NZ_CP018335.1\|WP_073540410.1\|4114597_4114960_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	9.07517e-09
NZ_CP018335.1\|WP_073540425.1\|4130050_4130809_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213232	cd03265, ABC_DrrA, Daunorubicin/doxorubicin resistance ATP-binding protein. DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin. In addition to DrrA, the complex includes an integral membrane protein called DrrB. DrrA belongs to the ABC family of transporters and shares sequence and functional similarities with a protein found in cancer cells called P-glycoprotein. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	1.46306e-96
NZ_CP018335.1\|WP_073540406.1\|4109482_4110844_-\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NZ_CP018335.1\|WP_073540404.1\|4107557_4108214_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	2.62507e-23

>NZ_CP018335.1|WP_073540412.1|4115361_4115745_-|hypothetical-protein
MGGIFMYKLEIKPEKNIFLITFKGLLSKKEGEEFLSELLRKLKTFDTSKYNLVVDTQELKVSTQDSTDNIKSTIELLVKTPFKGRYNVVPKSIIAELQAKRVVKNDIFNKITPIKSYESLLKSSANL
>NZ_CP018335.1|WP_073540411.1|4115044_4115239_-|alpha/beta-type-small-acid-soluble-spore-protein
MTRNNKLVVPEAREALNRFKMESAREVGVNLRDGYNGDLTAREAGSVGGNMVKKMIEAYEEDLK
>NZ_CP018335.1|WP_073540410.1|4114597_4114960_+|sulfite-exporter-TauE/SafE-family-protein
MLDVMIFIVIGIAAGILSGLFGIGGGIIIIPALMFFKGFSQLKAQGTSLIAMLPPVGIFAFIEYYKKGNTDLVGGIIICSTMLLSAKFGGQLANILPMNVMKKAFGIFIILVGIKTFFGK
>NZ_CP018335.1|WP_073540409.1|4112999_4113977_-|DMT-family-transporter
MSKLLILDIFCALIADAVWGLAYVIPNLLPDYTAVEITFGRYFVYGIFSVVMLLLQKQRSRRIMNTSVWKNAFVFSFCGNIGYYFFLVLSIKLTGAAIAALIIGMLPITTSLYGNFINHEFSFKKLIWPVFIVIMGILILNYALLNESTDTFNIYGVIYGLIALCLWTWYAIFNARFLKENSEITSQMWSTITGTTTLCLIPFFVLVIKIIMPDSLMLFKLINHGNIVFKFWCTAVILGIVVSWVGTVFWNRASNTLPISLAGQITVGETVFGLTYSFIIEGRLPHVIELISVTIIITGILYYIQTINCLNGDDEKYNVKDEKSR
>NZ_CP018335.1|WP_083585786.1|4112176_4113046_-|AraC-family-transcriptional-regulator
MEMMKNIMLKMKNHVEYTLRQDMRDMEILKASYTTQTFSRHWHENFGIGIIENGVEAFDYNKEKCYAPKSSIVLMNPGIIHTGQAVNQEKGWRYWIMYPSPIILQEVMKQINKRYFSMPYFPKAVVSDIYCEKSLYGMFQLLLDKSSSLLECQTSFFTTMIKVLKHHAKFSYEEKKINWNYKVADDIREYIDNNYNKNISLDELSIFSNMSKFNLIRVFEKRWGVPPHIYQIVVRIQKSKDLLIKGYPIVSTALKMGFADQSHFTRHFKRVVGITPYKYQTQLINSNVT
>NZ_CP018335.1|WP_073540407.1|4111627_4112113_-|dihydrofolate-reductase
MISLIAAVSKNNVIGNNGIIPWKIKGEQKRFKELTTGKTVIMGRKSFQEIGKPLPNRKIIIISNTVNIVADNCVTVRSLSEAFNLAKDEEEVFVAGGGQVYKEALPYSNKIYLTVVDKMIEGNVYFPTINKNDFVKTYEQRIEGELPYTYYTYERKCGKNK
>NZ_CP018335.1|WP_073540406.1|4109482_4110844_-|amino-acid-permease
MSENQNLSRGLKNRHVQLLAIGGAIGTGLFLGSGRSIHLAGPSILFAYTITGVVCFLIMRALGELLLSNLNYHSFVDFVQEYMGNGAAFITGWTYWFCWISLAMADLTASGLYIQYWLPNIAQWVPSLVVLIILLIMNLTTVKLFGEMEFWFALIKIVAILALIIIGTFMIIKGFSTKVGASSFTNLWNHGGWFPNGTSGFILSFQMVVFAFTGIELVGLTAGETENPEYVIPRAINNIPIRIIIFYIGALTVIMSIYPWNSINADKSPFVQVFAAVGIAAAASIVNFVVLTSAASACNSGIFSTSRMVYSLAKENNAPNSMKRLTSNKVPSNALMFSAAVILISVILSYIMPEGVFVLITSISTFCFIFIWGIMVVCHLKYRKTNPKLASKSKFKMPLYPITNYIVLAFIVFVLVVLALNKETRVALFVTPVWFIMLGIIYKILKSRVKKEK
>NZ_CP018335.1|WP_073540405.1|4108350_4109022_+|lactate-utilization-protein
MEEKNSAIKTRNELLATKLIKNLRSRKFEAYYCDNAIDAAEKALSLIPESSSVSWGGSVTLEEIELIERIYQGNFIIIDRDKAQTMDERYDLMRQSLLCDTYLTSFNAISEDGVLINIDSVGNRVAAITFGPKNVIAVIGMNKVCKTVEDAVARARTYAAPINAQRCSSNPFLHPPKKTPCVINGACGNCKAEDCICSYVIETRMCKTPGRIKIILVGESLGF
>NZ_CP018335.1|WP_073540404.1|4107557_4108214_-|Crp/Fnr-family-transcriptional-regulator
MDDLDILVQSHLFSGIEPNDIEKMLICLSAMRKEYEKGEMVVCEGDSVNDIGIILKGSARSTKLSITGKQIIVSLHYPGGYTAILTAASGKRKCPMSIQALESLAVLFIPVRNVLSRCKKLCIAHEQLLFNLFNSIAERALELHDRNDCLIMPTIRDKVLTYLTKVCHESKTRIVRIPFNREAMAGYLNVDRSALSRELAKMKRDGLIDFYKNKFELL
>NZ_CP018335.1|WP_073540403.1|4106036_4107473_+|HAMP-domain-containing-histidine-kinase
MKVKIVGIQTKFIITFIFSLIASFMIYESVYSTYISFASQKHPHKFENYNYSFSELSNISLNISLTASSVDFNNESIYKAVLSKYESKYSKYKLGFVAVDSKNNVLYNSSRLPKNLNLEKSYSDFLKYYISAGNLTRYNYYIYKMPIKTDTTTSILWITASPRNAPNDSKMLLFEFKSIIIMLSFCMLLFLIITHHRMKYINEICYGIKIIANENLNFKIRKKGHDELSEICKNINFMADKINEKIENEKRIEVSKNSLITNVAHDIRSPLTSIIGFLQIVKNSEYKSQEEMKRFIGICLKKAETMKKLTDNLFMFTKLNDSSVKLHLSTICLNELIYQLIDEFEMAFENSKLKIIDNICTESIMITVDVNLFVRALNNLMYNALKYSFKPSNVHVSLIQHDKKVVLGIRNRCENLNVETINTLFEKFYRADASRTNPDEGSGLGLSITKSIIERHGGNICANCEKDMITFTVSIPLN
>NZ_CP018335.1|WP_156876112.1|4117512_4118762_-|IS3-family-transposase
MKGKSYTKELKEEVLREVKEVGNVSLVSRRHGISKSTIFTWIKNSKDEIKVKPGRKALVEGEKELENELTEVTKENDHLKKLLGEKDLEVAILRDLNKKIKPSIKEKVEIAKKYIDQGYNAVFVLKVVKLGRSTYYYNLSVEGKEKARPKGGKPKGYSINVDGEKVCDDQIKEFILEAIDGDAINYGYRKITYHLRKYYNLVINHKKVYRLCKELRILKDQRIIKAKIKRNIAVNRTITGSNQLWEMDIKYGYIEGEDKFFYLLNLIDIFDRSIIDYHMGLHCEAKDATALLRKCLIRRNLFEEGSKKPVIRTDNGPQFISHKFDECCEGLKTEHERIPVKTPNKNAHVKSFHRILEDECLKINEFQSYAEAYKIVNEFMEFYNNRRLHSSLRFMAPHEFYNLYFGENLTNIQIRV
>NZ_CP018335.1|WP_073540414.1|4118846_4119986_+|hypothetical-protein
MIFSGCSNNGTTLYNAINKTQKIKSSEIKSDITLNISTDNLSAQEQEVMQTIVPLVNDSKLSIVTYINQNGDNTAYQMKNDIKITGAASLNMGFWMNMDTTKETPVVNEIFKMPDVLTKQLPDEFKNKGYMVMDYDDMAGIQGASQIDYKKLAEFNKKFQSKFLQFMAEYTKQFNPNLNIINKVSTENTNDSTIAQPVSVYQIKLDDKTFKDLIHYTLNNFAENKDAMAFLKDYMTSLNSIMGLSQDQENLNKTFDEMPQMITQLNKKLAALDNVKILGDKGITLQYTVSNDGYIVKETGNAEFVINLPELNELSQSDISQQDQNNQKLTGIYTIDFNFNNRYYTINGYNPVTFPALNEYNSFNYADLLKTIPAQSSGK
>NZ_CP018335.1|WP_073540415.1|4120544_4120865_-|hypothetical-protein
MSINDSNDNSNEKVENSYDFEAPMYCPYCLMPYNRPIQNEYTDVEPYDEDFNENFDYDFNPEYRHRSHRRRRRRRRRRRHRRRCRRNICESPLFPLFYDYDDWYWY
>NZ_CP018335.1|WP_073540417.1|4122502_4123708_-|MFS-transporter
MNYIQKDTREFRMVSIALFAGGFNTFAILYSTQPLMPYLSREFAISPTVASLSLSVTTCILAVSMLIFGSLSEVLGRKPIMSFAIFTSSILAVLTAFVPNFHGLLILRGLQGFVLAGLPAIAMAYISEEIDGASLGMVMGLYISGNSIGGMSGRIIIGVITGLFNWRMALACIGILGVLASVIFWTKLPASKHFEPRSFEINKLLRSMVNHLKSPDLICLYCIGFLIMGSFVALYNFIGFQLVKPPYSLSSTLVSFIFVIYVVGTFSSTFMGHLADTHGEHKVLYIALLTMFIGAFITLDIKLALKIIGIALLTFGFFGCHSIVSGWIGKVATHDKAQASSLYLLFYYVGSSVGGTAGGTFWSSYGWYGVVGMIVCFLSLAFFISIRLPSITTVVNAQEHR
>NZ_CP018335.1|WP_073540418.1|4123922_4124783_+|LysR-family-transcriptional-regulator
MDNRQMSYFLAIIEEGSITKAANKLHLAQPYLSQQLKLLEDELEVKLVERTTRKFQVTEAGKMLAYRAKQILDLAEKAIKELKDFNEGIKGTLSIGCLSSATENLLTQKIYDFHKKYPDINFEIRQCSTDEILELLKRGVIEIGIVRSPLNLDIFESIPLPVEPMTAVSNNQIDLGKNDNYISLEELSTKPLLVHRRFEKDILSFFHKKGLKPRILCKIEDTRSILLLAGLGIGVGIVPKDWTNLTHSQNLRYKEIPELHLNTNIVITRLKNHYLTSVARHFLETF
>NZ_CP018335.1|WP_073540420.1|4125549_4128450_-|DEAD/DEAH-box-helicase
MESIFDKINSIEKKDSNNFNIKNKEIENSGFIVNNELIVNSEEGNLLQELKICLSQCNGFYFSVAFINFSGVQLLLDGFQELEKKGIKGKILTSTYLNFTEPKALERIRNFSNIDLKVFIANKDKGFHTKAYIFENREEYKIIIGSSNITQRALKSNVEWNVKVVSKKDNSFTRQVLEEYLGLWDSTTIVSDEFLNSYRSFLKEIKKSETNKALDFSNYELIKPNKMQEMAIKSLDRLRHSGENKALVIAATGTGKTYMSAFDVIKYNPRRMLFLVHREEILRDAEKTFKKLVKNKNKSTGLLTGTGKEIDADYVFSTVQSMNNYIDNFKKDDFEYIIVDEAHHAASSSYKKIMDYFKPKFLLGMTATPERCDGGNIFDIFSGNIALEVRLREALEQELIVPFHYFGITDIDGIDLSDVSLQDIDEIVKRLKVNERVDFIVEKMLFYGHDGEKRKCIGFCASIDHAEYMAGEFNKRGIKSVCLTGKNSPNERAVYIKRLENNNDELEVIFTVDIFNEGVDIPSINLVLMLRPTSSPIIFIQQLGRGLRKHKGKTFLTVLDFIGNHKKVFLIAIALNGSRYYDKDSLKVAVSTQFGNIPGCTNIQMDKVAEERILEQLNKENFNSMKYLKDEYLEFKKMNGEKVPYFLMDYIKYDGAPDPLKFLNKEKTYLSFVVKMENQKELESILEDDDFFKILKEFTDKLPIKRIYEFSILKYLLNHEQITLKQARCEILKYIDYVDDNSIIHAFNCLNQNYYDTAQIKSTVKLVEFQDEILARTWKFKKVIHNKEYRCYIEDIINYALITYEKRFSSNYYGVPFFKLYEQYKMVDVALLSNYTKIHSSFRGSGLITSESEYFIFVDLHKEKNIKESINYKDKLIDRNYFQWQSPNSTSQSSERGKNIIFNKQRGINLHIFLRKYKKIDGVVQPYIYMGKGYVVECKGEKPITVKIKLENEVPITIYTEFIKKV
>NZ_CP018335.1|WP_073540422.1|4128529_4128916_-|(deoxy)nucleoside-triphosphate-pyrophosphohydrolase
MKTVEVVAAIIKHGNKIFTTCRGYGEFKNMWEFPGGKIESGETREEALIREIKEELELDIHVSKYVTTIEYDYPNFHLTMHCFLCDICGGKIHLNAHNAAKWIPLDELDKLRWVPADILVVEKLKDRR
>NZ_CP018335.1|WP_073540424.1|4129279_4130050_-|ABC-transporter-permease
METVKKHFFSDMGVMLGRSMRHVTRSMDTIITVTIMPIAFMLLFVYVFGGAIQTGTDNYVNYLLPGVLLIAIASGIAYTAYRLFMDMQRGIFERFHSMPIARSAALWGHVLTSLVSNAISVVVIILVALIMGFRSPAGVLSWLAVAGILTLFTLALTWIAVIAGLSAKSVDGAGAFSYPLLFLPFISSAFVPTESMPSGVRTFAENQPVTSIVDAIRSLLVGQPVGNDIWVALAWCLGILIIAYLFAICAYKRKAA
>NZ_CP018335.1|WP_073540425.1|4130050_4130809_-|ATP-binding-cassette-domain-containing-protein
MEKAIQVKGLQKSYKKFHVLKGVDFEVEKGSIFALLGSNGAGKTTIVKILTTLLKQDSGAATVNGFDVAAKPDYVRQSISLTGQFAAVDEILTGRENLIMIAKLRHLANPRQIADDLLKRFGLIDAADRRVSTYSGGMRRRLDIAMSLIGNPQLIFLDEPTTGLDPEARIKVWKTVKELAEGGTTVFLTTQYLEEAEQLADRIAILHEGKIIANGTLDELKRLFPPAKVEYVEKQPTLEEIFLAIIGKKEEK
>NZ_CP018335.1|WP_073540427.1|4130824_4131175_-|DUF1048-domain-containing-protein
MSIQDIIEGKKEWRAHVVRVKALPQDYQIVYKEIQKYLFKVGPVELTDGMGLLSGIIDLFEEGAALGKGVLEVTGSDVAAFCDDLIKDSKTCADIYQESVDQEVNKAMKKVTDKTK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP018335_4	4.2\|2659847\|37\|NZ_CP018335\|CRT,PILER-CR,CRISPRCasFinder	2659847-2659883	37	NZ_CP018335.1	1787273-1787309	0	1.0
NZ_CP018335_2	2.2\|2066079\|36\|NZ_CP018335\|CRT,CRISPRCasFinder	2066079-2066114	36	NZ_CP018336.1	42511-42546	1	0.972

1. spacer 4.2|2659847|37|NZ_CP018335|CRT,PILER-CR,CRISPRCasFinder matches to position: 1787273-1787309, mismatch: 0, identity: 1.0

cagattgggttgttggcactattgcacatttagccgc	CRISPR spacer
cagattgggttgttggcactattgcacatttagccgc	Protospacer
*************************************

2. spacer 2.2|2066079|36|NZ_CP018335|CRT,CRISPRCasFinder matches to position: 42511-42546, mismatch: 1, identity: 0.972

ataactggtccgaaagctgctgctgcaagcccaaga	CRISPR spacer
ataactggtccgaaagctgctgctgcaagcccgaga	Protospacer
********************************.***

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP018335_2	2.2\|2066079\|36\|NZ_CP018335\|CRT,CRISPRCasFinder	2066079-2066114	36	NZ_CP018336	Clostridium kluyveri strain JZZ plasmid unnamed, complete sequence	42511-42546	1	0.972
NZ_CP018335_2	2.9\|2066546\|38\|NZ_CP018335\|CRT,CRISPRCasFinder,PILER-CR	2066546-2066583	38	NC_011836	Clostridium kluyveri NBRC 12016 plasmid pCKL1, complete sequence	4718-4755	1	0.974
NZ_CP018335_2	2.9\|2066546\|38\|NZ_CP018335\|CRT,CRISPRCasFinder,PILER-CR	2066546-2066583	38	NC_009466	Clostridium kluyveri DSM 555 plasmid pCKL555A, complete sequence	41847-41884	1	0.974
NZ_CP018335_4	4.9\|2660302\|35\|NZ_CP018335\|CRT,PILER-CR,CRISPRCasFinder	2660302-2660336	35	NZ_CP018336	Clostridium kluyveri strain JZZ plasmid unnamed, complete sequence	36394-36428	3	0.914
NZ_CP018335_3	3.19\|2074272\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2074272-2074308	37	NC_011836	Clostridium kluyveri NBRC 12016 plasmid pCKL1, complete sequence	38668-38704	5	0.865
NZ_CP018335_3	3.19\|2074272\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2074272-2074308	37	NC_009466	Clostridium kluyveri DSM 555 plasmid pCKL555A, complete sequence	7898-7934	5	0.865
NZ_CP018335_5	5.11\|4116491\|32\|NZ_CP018335\|PILER-CR	4116491-4116522	32	MN694382	Marine virus AFVG_250M235, complete genome	31680-31711	5	0.844
NZ_CP018335_5	5.4\|4116491\|33\|NZ_CP018335\|CRISPRCasFinder	4116491-4116523	33	MN694382	Marine virus AFVG_250M235, complete genome	31680-31712	6	0.818
NZ_CP018335_5	5.8\|4116492\|32\|NZ_CP018335\|CRT	4116492-4116523	32	MN694382	Marine virus AFVG_250M235, complete genome	31681-31712	6	0.812
NZ_CP018335_4	4.6\|2660109\|35\|NZ_CP018335\|CRT,PILER-CR,CRISPRCasFinder	2660109-2660143	35	NZ_CP049605	Klebsiella pneumoniae strain Kp8701 plasmid unnamed, complete sequence	184678-184712	8	0.771
NZ_CP018335_4	4.6\|2660109\|35\|NZ_CP018335\|CRT,PILER-CR,CRISPRCasFinder	2660109-2660143	35	NZ_CP015132	Klebsiella pneumoniae strain Kpn555 plasmid pKPN-d90, complete sequence	18122-18156	8	0.771
NZ_CP018335_4	4.6\|2660109\|35\|NZ_CP018335\|CRT,PILER-CR,CRISPRCasFinder	2660109-2660143	35	NZ_CP022824	Klebsiella quasivariicola strain KPN1705 plasmid pKPN1705-1, complete sequence	112224-112258	8	0.771
NZ_CP018335_4	4.6\|2660109\|35\|NZ_CP018335\|CRT,PILER-CR,CRISPRCasFinder	2660109-2660143	35	CP052387	Klebsiella pneumoniae strain C17KP0055 plasmid pC17KP0055-1, complete sequence	115430-115464	8	0.771
NZ_CP018335_4	4.6\|2660109\|35\|NZ_CP018335\|CRT,PILER-CR,CRISPRCasFinder	2660109-2660143	35	MN823997	Klebsiella pneumoniae strain 111119051 plasmid p19051-FIIK, complete sequence	27843-27877	8	0.771
NZ_CP018335_4	4.7\|2660174\|34\|NZ_CP018335\|CRT,PILER-CR,CRISPRCasFinder	2660174-2660207	34	NZ_CP043029	Pseudobutyrivibrio xylanivorans strain MA3014 plasmid pNP95, complete sequence	13982-14015	8	0.765
NZ_CP018335_3	3.7\|2073470\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2073470-2073506	37	NC_018878	Bacillus thuringiensis Bt407 plasmid BTB_502p, complete sequence	23348-23384	9	0.757
NZ_CP018335_3	3.14\|2073934\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2073934-2073970	37	MN905160	Pseudomonas phage PE09, complete genome	24218-24254	9	0.757
NZ_CP018335_5	5.8\|4116492\|32\|NZ_CP018335\|CRT	4116492-4116523	32	NZ_CP029068	Enterococcus mundtii strain Pe103 plasmid pPe10302, complete sequence	27186-27217	9	0.719
NZ_CP018335_5	5.8\|4116492\|32\|NZ_CP018335\|CRT	4116492-4116523	32	NZ_CP029068	Enterococcus mundtii strain Pe103 plasmid pPe10302, complete sequence	30343-30374	9	0.719
NZ_CP018335_5	5.8\|4116492\|32\|NZ_CP018335\|CRT	4116492-4116523	32	NC_022879	Enterococcus mundtii QU 25 plasmid pQY182, complete sequence	70165-70196	9	0.719
NZ_CP018335_5	5.11\|4116491\|32\|NZ_CP018335\|PILER-CR	4116491-4116522	32	NZ_CP029068	Enterococcus mundtii strain Pe103 plasmid pPe10302, complete sequence	27187-27218	9	0.719
NZ_CP018335_5	5.11\|4116491\|32\|NZ_CP018335\|PILER-CR	4116491-4116522	32	NZ_CP029068	Enterococcus mundtii strain Pe103 plasmid pPe10302, complete sequence	30344-30375	9	0.719
NZ_CP018335_5	5.11\|4116491\|32\|NZ_CP018335\|PILER-CR	4116491-4116522	32	NC_022879	Enterococcus mundtii QU 25 plasmid pQY182, complete sequence	70166-70197	9	0.719
NZ_CP018335_2	2.4\|2066212\|37\|NZ_CP018335\|CRT,CRISPRCasFinder,PILER-CR	2066212-2066248	37	MN693005	Marine virus AFVG_117M50, complete genome	50696-50732	10	0.73
NZ_CP018335_3	3.14\|2073934\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2073934-2073970	37	MT670422	Pseudomonas phage phiPsa397, complete genome	23564-23600	10	0.73
NZ_CP018335_3	3.14\|2073934\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2073934-2073970	37	NC_023601	Pseudomonas phage phiPsa374, complete genome	23354-23390	10	0.73
NZ_CP018335_3	3.14\|2073934\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2073934-2073970	37	MT670418	Pseudomonas phage phiPsa300, complete genome	23720-23756	10	0.73
NZ_CP018335_3	3.14\|2073934\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2073934-2073970	37	MT670420	Pseudomonas phage phiPsa347, complete genome	23959-23995	10	0.73
NZ_CP018335_3	3.14\|2073934\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2073934-2073970	37	MT670421	Pseudomonas phage phiPsa381, complete genome	23133-23169	10	0.73
NZ_CP018335_3	3.14\|2073934\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2073934-2073970	37	MT670419	Pseudomonas phage phiPsa315, complete genome	24348-24384	10	0.73
NZ_CP018335_3	3.14\|2073934\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2073934-2073970	37	MT670417	Pseudomonas phage phiPsa267, complete genome	23823-23859	10	0.73
NZ_CP018335_3	3.16\|2074069\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2074069-2074105	37	MN445185	Escherichia phage vB_EcoM_EC001, complete genome	53334-53370	10	0.73
NZ_CP018335_3	3.16\|2074069\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2074069-2074105	37	KU726251	Enterobacteria phage SEGD1, complete genome	50702-50738	10	0.73
NZ_CP018335_3	3.16\|2074069\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2074069-2074105	37	MT679221	Proteus phage 7, complete genome	52689-52725	10	0.73
NZ_CP018335_3	3.16\|2074069\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2074069-2074105	37	NC_027402	Salmonella phage SPN3US, complete genome	50902-50938	10	0.73
NZ_CP018335_3	3.16\|2074069\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2074069-2074105	37	MT799840	Salmonella phage JN03, complete genome	52679-52715	10	0.73
NZ_CP018335_4	4.6\|2660109\|35\|NZ_CP018335\|CRT,PILER-CR,CRISPRCasFinder	2660109-2660143	35	NZ_AP018442	Undibacterium sp. YM2 plasmid pUYM01, complete sequence	131731-131765	10	0.714
NZ_CP018335_5	5.9\|4116362\|32\|NZ_CP018335\|PILER-CR	4116362-4116393	32	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	1749470-1749501	10	0.688
NZ_CP018335_3	3.16\|2074069\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2074069-2074105	37	MH221129	Salmonella phage SPAsTU, complete genome	84423-84459	11	0.703
NZ_CP018335_3	3.16\|2074069\|37\|NZ_CP018335\|CRISPRCasFinder,CRT,PILER-CR	2074069-2074105	37	MH221128	Salmonella phage STsAS, complete genome	155987-156023	11	0.703
NZ_CP018335_4	4.6\|2660109\|35\|NZ_CP018335\|CRT,PILER-CR,CRISPRCasFinder	2660109-2660143	35	NZ_CP034156	Rhodococcus sp. NJ-530 plasmid unnamed4, complete sequence	326121-326155	11	0.686

1. spacer 2.2|2066079|36|NZ_CP018335|CRT,CRISPRCasFinder matches to NZ_CP018336 (Clostridium kluyveri strain JZZ plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.972

ataactggtccgaaagctgctgctgcaagcccaaga	CRISPR spacer
ataactggtccgaaagctgctgctgcaagcccgaga	Protospacer
********************************.***

2. spacer 2.9|2066546|38|NZ_CP018335|CRT,CRISPRCasFinder,PILER-CR matches to NC_011836 (Clostridium kluyveri NBRC 12016 plasmid pCKL1, complete sequence) position: , mismatch: 1, identity: 0.974

cctttccagtccagggagccaattcataggagttcctg	CRISPR spacer
cctttccagtccaggtagccaattcataggagttcctg	Protospacer
*************** **********************

3. spacer 2.9|2066546|38|NZ_CP018335|CRT,CRISPRCasFinder,PILER-CR matches to NC_009466 (Clostridium kluyveri DSM 555 plasmid pCKL555A, complete sequence) position: , mismatch: 1, identity: 0.974

cctttccagtccagggagccaattcataggagttcctg	CRISPR spacer
cctttccagtccaggtagccaattcataggagttcctg	Protospacer
*************** **********************

4. spacer 4.9|2660302|35|NZ_CP018335|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP018336 (Clostridium kluyveri strain JZZ plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.914

agcagttcaagcctcaaagtaaatatattacaagt	CRISPR spacer
agcagttcaggcctcaaggtaaatatattacaagc	Protospacer
*********.*******.****************.

5. spacer 3.19|2074272|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to NC_011836 (Clostridium kluyveri NBRC 12016 plasmid pCKL1, complete sequence) position: , mismatch: 5, identity: 0.865

tgaaaagtgctgtattgcagcagtatcctaagaaaaa	CRISPR spacer
tgaaaagtgctgtactgcagcagtaccctaagaggga	Protospacer
**************.**********.*******...*

6. spacer 3.19|2074272|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to NC_009466 (Clostridium kluyveri DSM 555 plasmid pCKL555A, complete sequence) position: , mismatch: 5, identity: 0.865

tgaaaagtgctgtattgcagcagtatcctaagaaaaa	CRISPR spacer
tgaaaagtgctgtactgcagcagtaccctaagaggga	Protospacer
**************.**********.*******...*

7. spacer 5.11|4116491|32|NZ_CP018335|PILER-CR matches to MN694382 (Marine virus AFVG_250M235, complete genome) position: , mismatch: 5, identity: 0.844

tctactatttgttttttagtagttcctcttcc	CRISPR spacer
tctgctatttgtcttttagtagttccttcttc	Protospacer
***.********.**************..*.*

8. spacer 5.4|4116491|33|NZ_CP018335|CRISPRCasFinder matches to MN694382 (Marine virus AFVG_250M235, complete genome) position: , mismatch: 6, identity: 0.818

tctactatttgttttttagtagttcctcttcct	CRISPR spacer
tctgctatttgtcttttagtagttccttcttca	Protospacer
***.********.**************..*.*

9. spacer 5.8|4116492|32|NZ_CP018335|CRT matches to MN694382 (Marine virus AFVG_250M235, complete genome) position: , mismatch: 6, identity: 0.812

ctactatttgttttttagtagttcctcttcct	CRISPR spacer
ctgctatttgtcttttagtagttccttcttca	Protospacer
**.********.**************..*.*

10. spacer 4.6|2660109|35|NZ_CP018335|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP049605 (Klebsiella pneumoniae strain Kp8701 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.771

tataccca---cctggataacatccagcacctcttcca	CRISPR spacer
---ggccagatcccggataacgtccagcacctcttcaa	Protospacer
   . ***   **.*******.************** *

11. spacer 4.6|2660109|35|NZ_CP018335|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP015132 (Klebsiella pneumoniae strain Kpn555 plasmid pKPN-d90, complete sequence) position: , mismatch: 8, identity: 0.771

tataccca---cctggataacatccagcacctcttcca	CRISPR spacer
---ggccagatcccggataacgtccagcacctcttcaa	Protospacer
   . ***   **.*******.************** *

12. spacer 4.6|2660109|35|NZ_CP018335|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP022824 (Klebsiella quasivariicola strain KPN1705 plasmid pKPN1705-1, complete sequence) position: , mismatch: 8, identity: 0.771

tataccca---cctggataacatccagcacctcttcca	CRISPR spacer
---ggccagatcccggataacgtccagcacctcttcaa	Protospacer
   . ***   **.*******.************** *

13. spacer 4.6|2660109|35|NZ_CP018335|CRT,PILER-CR,CRISPRCasFinder matches to CP052387 (Klebsiella pneumoniae strain C17KP0055 plasmid pC17KP0055-1, complete sequence) position: , mismatch: 8, identity: 0.771

tataccca---cctggataacatccagcacctcttcca	CRISPR spacer
---ggccagatcccggataacgtccagcacctcttcaa	Protospacer
   . ***   **.*******.************** *

14. spacer 4.6|2660109|35|NZ_CP018335|CRT,PILER-CR,CRISPRCasFinder matches to MN823997 (Klebsiella pneumoniae strain 111119051 plasmid p19051-FIIK, complete sequence) position: , mismatch: 8, identity: 0.771

tataccca---cctggataacatccagcacctcttcca	CRISPR spacer
---ggccagatcccggataacgtccagcacctcttcaa	Protospacer
   . ***   **.*******.************** *

15. spacer 4.7|2660174|34|NZ_CP018335|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP043029 (Pseudobutyrivibrio xylanivorans strain MA3014 plasmid pNP95, complete sequence) position: , mismatch: 8, identity: 0.765

agttttatca----aaaaatccagagacttttgtagaa	CRISPR spacer
----ttactacaataacaatccagagacttttggagaa	Protospacer
    ***..*    ** **************** ****

16. spacer 3.7|2073470|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to NC_018878 (Bacillus thuringiensis Bt407 plasmid BTB_502p, complete sequence) position: , mismatch: 9, identity: 0.757

aggcagttactcctttgaatttaaaaactgaattaga---	CRISPR spacer
gggcatttacacctttgaatttaaaaa---aatgcaaggg	Protospacer
.**** **** ****************   ***  .*

17. spacer 3.14|2073934|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to MN905160 (Pseudomonas phage PE09, complete genome) position: , mismatch: 9, identity: 0.757

tttcattgtcattattcatttccctccattttctttt	CRISPR spacer
aagttttgccattattcatttccctccatttcatctt	Protospacer
   . ***.**********************. *.**

18. spacer 5.8|4116492|32|NZ_CP018335|CRT matches to NZ_CP029068 (Enterococcus mundtii strain Pe103 plasmid pPe10302, complete sequence) position: , mismatch: 9, identity: 0.719

ctactatttgttttttagtagttcctcttcct	CRISPR spacer
ttcagattcgttttttagtatttcctctaaca	Protospacer
.*   ***.*********** *******  *

19. spacer 5.8|4116492|32|NZ_CP018335|CRT matches to NZ_CP029068 (Enterococcus mundtii strain Pe103 plasmid pPe10302, complete sequence) position: , mismatch: 9, identity: 0.719

ctactatttgttttttagtagttcctcttcct	CRISPR spacer
ttcagattcgttttttagtatttcctctaaca	Protospacer
.*   ***.*********** *******  *

20. spacer 5.8|4116492|32|NZ_CP018335|CRT matches to NC_022879 (Enterococcus mundtii QU 25 plasmid pQY182, complete sequence) position: , mismatch: 9, identity: 0.719

ctactatttgttttttagtagttcctcttcct	CRISPR spacer
ttcagattcgttttttagtatttcctctaaca	Protospacer
.*   ***.*********** *******  *

21. spacer 5.11|4116491|32|NZ_CP018335|PILER-CR matches to NZ_CP029068 (Enterococcus mundtii strain Pe103 plasmid pPe10302, complete sequence) position: , mismatch: 9, identity: 0.719

tctactatttgttttttagtagttcctcttcc	CRISPR spacer
gttcagattcgttttttagtatttcctctaac	Protospacer
 .*   ***.*********** *******  *

22. spacer 5.11|4116491|32|NZ_CP018335|PILER-CR matches to NZ_CP029068 (Enterococcus mundtii strain Pe103 plasmid pPe10302, complete sequence) position: , mismatch: 9, identity: 0.719

tctactatttgttttttagtagttcctcttcc	CRISPR spacer
gttcagattcgttttttagtatttcctctaac	Protospacer
 .*   ***.*********** *******  *

23. spacer 5.11|4116491|32|NZ_CP018335|PILER-CR matches to NC_022879 (Enterococcus mundtii QU 25 plasmid pQY182, complete sequence) position: , mismatch: 9, identity: 0.719

tctactatttgttttttagtagttcctcttcc	CRISPR spacer
gttcagattcgttttttagtatttcctctaac	Protospacer
 .*   ***.*********** *******  *

24. spacer 2.4|2066212|37|NZ_CP018335|CRT,CRISPRCasFinder,PILER-CR matches to MN693005 (Marine virus AFVG_117M50, complete genome) position: , mismatch: 10, identity: 0.73

cataagcctttttaataatatctactacaccattaaa	CRISPR spacer
cgacattatttttaataatatctcctaaaccattatc	Protospacer
*.  * . *************** *** *******

25. spacer 3.14|2073934|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to MT670422 (Pseudomonas phage phiPsa397, complete genome) position: , mismatch: 10, identity: 0.73

tttcattgtcattattcatttccctccattttctttt	CRISPR spacer
aagttttgccattattcatttccctccagttcatctt	Protospacer
   . ***.******************* **. *.**

26. spacer 3.14|2073934|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to NC_023601 (Pseudomonas phage phiPsa374, complete genome) position: , mismatch: 10, identity: 0.73

tttcattgtcattattcatttccctccattttctttt	CRISPR spacer
aagttttgccattattcatttccctccagttcatctt	Protospacer
   . ***.******************* **. *.**

27. spacer 3.14|2073934|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to MT670418 (Pseudomonas phage phiPsa300, complete genome) position: , mismatch: 10, identity: 0.73

tttcattgtcattattcatttccctccattttctttt	CRISPR spacer
aagttttgccattattcatttccctccagttcatctt	Protospacer
   . ***.******************* **. *.**

28. spacer 3.14|2073934|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to MT670420 (Pseudomonas phage phiPsa347, complete genome) position: , mismatch: 10, identity: 0.73

tttcattgtcattattcatttccctccattttctttt	CRISPR spacer
aagttttgccattattcatttccctccagttcatctt	Protospacer
   . ***.******************* **. *.**

29. spacer 3.14|2073934|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to MT670421 (Pseudomonas phage phiPsa381, complete genome) position: , mismatch: 10, identity: 0.73

tttcattgtcattattcatttccctccattttctttt	CRISPR spacer
aagttttgccattattcatttccctccagttcatctt	Protospacer
   . ***.******************* **. *.**

30. spacer 3.14|2073934|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to MT670419 (Pseudomonas phage phiPsa315, complete genome) position: , mismatch: 10, identity: 0.73

tttcattgtcattattcatttccctccattttctttt	CRISPR spacer
aagttttgccattattcatttccctccagttcatctt	Protospacer
   . ***.******************* **. *.**

31. spacer 3.14|2073934|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to MT670417 (Pseudomonas phage phiPsa267, complete genome) position: , mismatch: 10, identity: 0.73

tttcattgtcattattcatttccctccattttctttt	CRISPR spacer
aagttttgccattattcatttccctccagttcatctt	Protospacer
   . ***.******************* **. *.**

32. spacer 3.16|2074069|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to MN445185 (Escherichia phage vB_EcoM_EC001, complete genome) position: , mismatch: 10, identity: 0.73

tgaaaatggtagaaaaaacatttgagacttgttctac	CRISPR spacer
taaaaatggcagaaaaaacatttgagacatcgctcgt	Protospacer
*.*******.****************** *  .....

33. spacer 3.16|2074069|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to KU726251 (Enterobacteria phage SEGD1, complete genome) position: , mismatch: 10, identity: 0.73

tgaaaatggtagaaaaaacatttgagacttgttctac	CRISPR spacer
taaaaatggcagaaaaaacatttgagacatcgctcgt	Protospacer
*.*******.****************** *  .....

34. spacer 3.16|2074069|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to MT679221 (Proteus phage 7, complete genome) position: , mismatch: 10, identity: 0.73

tgaaaatggtagaaaaaacatttgagacttgttctac	CRISPR spacer
taaaaatggcagaaaaaacatttgagacatcgctcgt	Protospacer
*.*******.****************** *  .....

35. spacer 3.16|2074069|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to NC_027402 (Salmonella phage SPN3US, complete genome) position: , mismatch: 10, identity: 0.73

tgaaaatggtagaaaaaacatttgagacttgttctac	CRISPR spacer
taaaaatggcagaaaaaacatttgagacatcgctcgt	Protospacer
*.*******.****************** *  .....

36. spacer 3.16|2074069|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to MT799840 (Salmonella phage JN03, complete genome) position: , mismatch: 10, identity: 0.73

tgaaaatggtagaaaaaacatttgagacttgttctac	CRISPR spacer
taaaaatggcagaaaaaacatttgagacatcgctcgt	Protospacer
*.*******.****************** *  .....

37. spacer 4.6|2660109|35|NZ_CP018335|CRT,PILER-CR,CRISPRCasFinder matches to NZ_AP018442 (Undibacterium sp. YM2 plasmid pUYM01, complete sequence) position: , mismatch: 10, identity: 0.714

tatacccacctggataacatccagcacctcttcca--------	CRISPR spacer
tacacccacctggagaacatccag--------ccaggccaaag	Protospacer
**.*********** *********        ***

38. spacer 5.9|4116362|32|NZ_CP018335|PILER-CR matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 10, identity: 0.688

gtgcgaatgtatgtgccactgttagacgttcc	CRISPR spacer
gtgcgaatgtctgtgcaactgttccttcgctc	Protospacer
********** ***** ******   .  ..*

39. spacer 3.16|2074069|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to MH221129 (Salmonella phage SPAsTU, complete genome) position: , mismatch: 11, identity: 0.703

tgaaaatggtagaaaaaacatttgagacttgttctac	CRISPR spacer
taaaaatggcagaaaaaacttttgagacatcgctcgt	Protospacer
*.*******.********* ******** *  .....

40. spacer 3.16|2074069|37|NZ_CP018335|CRISPRCasFinder,CRT,PILER-CR matches to MH221128 (Salmonella phage STsAS, complete genome) position: , mismatch: 11, identity: 0.703

tgaaaatggtagaaaaaacatttgagacttgttctac	CRISPR spacer
taaaaatggcagaaaaaacttttgagacatcgctcgt	Protospacer
*.*******.********* ******** *  .....

41. spacer 4.6|2660109|35|NZ_CP018335|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP034156 (Rhodococcus sp. NJ-530 plasmid unnamed4, complete sequence) position: , mismatch: 11, identity: 0.686

tatacccacctggataacatccagcacctcttcca	CRISPR spacer
gcggcatcgctggataacgtccagcgcctcttccc	Protospacer
   .* .  *********.******.********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

20861 : 51443

Clostridium_phage(20.0%)

tail,integrase,head,protease,capsid,portal,terminase,tRNA

attL 30304:30319|attR 55396:55411

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073536995.1\|20861_22142_+\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	7.2e-94	52.6
WP_073536997.1\|23414_24113_+	VanR-ABDEGLN family DNA-binding response regulator	W8CYM9	Bacillus_phage	2.9e-44	41.7
WP_083585610.1\|24102_25257_+	HAMP domain-containing histidine kinase	A0A1X9VNV7	Mimivirus	8.7e-06	25.0
WP_073537000.1\|25769_26702_+	D-alanyl-D-alanine carboxypeptidase	NA	NA	NA	NA
WP_073537002.1\|27428_27878_+	YsnF/AvaK domain-containing protein	NA	NA	NA	NA
WP_073537003.1\|28138_28597_+	YsnF/AvaK domain-containing protein	NA	NA	NA	NA
WP_073537004.1\|28672_29536_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_073537005.1\|29695_29908_-	hypothetical protein	NA	NA	NA	NA
WP_073537006.1\|30159_30630_-	hypothetical protein	NA	NA	NA	NA
30304:30319	attL	NA	NA	NA	NA
WP_083585800.1\|30788_30950_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073537007.1\|31098_31515_+	transcriptional regulator	A0A0A8WJ60	Clostridium_phage	1.3e-07	32.4
WP_073537008.1\|31593_32016_+	hypothetical protein	NA	NA	NA	NA
WP_073537009.1\|32133_32691_+	Uma2 family endonuclease	NA	NA	NA	NA
WP_073537010.1\|32711_33287_+	Uma2 family endonuclease	NA	NA	NA	NA
WP_083585611.1\|33343_34237_+\|integrase	site-specific integrase	A0A2H4JCB7	uncultured_Caudovirales_phage	5.7e-29	35.8
WP_073537011.1\|34286_34808_+	dCTP deaminase	R4T945	Halovirus	8.7e-14	34.5
WP_073537012.1\|35522_35840_+	histidine kinase	NA	NA	NA	NA
WP_073537013.1\|35899_36088_-	hypothetical protein	NA	NA	NA	NA
WP_073537014.1\|36099_36435_-\|head	phage head closure protein	NA	NA	NA	NA
WP_073537015.1\|36448_38092_-\|terminase	terminase large subunit	A0A290GJW3	Caldibacillus_phage	2.6e-160	53.0
WP_073537016.1\|38096_38441_-	hypothetical protein	A0A290GJQ7	Caldibacillus_phage	1.6e-16	44.8
WP_073537017.1\|38569_38869_-	HNH endonuclease	R9TNN2	Paenibacillus_phage	1.5e-18	46.8
WP_073537018.1\|38861_39155_-\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_156875975.1\|39210_39357_-	hypothetical protein	NA	NA	NA	NA
WP_073537019.1\|39374_40583_-\|capsid	phage major capsid protein	NA	NA	NA	NA
WP_073537020.1\|40595_40781_-	hypothetical protein	NA	NA	NA	NA
WP_073537021.1\|40781_41354_-\|head,protease	HK97 family phage prohead protease	A0A0M7RF71	Lactobacillus_phage	1.8e-12	28.2
WP_073537022.1\|41319_42546_-\|portal	phage portal protein	H7BUQ2	unidentified_phage	1.3e-44	30.8
WP_073537023.1\|42775_43174_-	hypothetical protein	NA	NA	NA	NA
WP_073537024.1\|43445_43796_-	hypothetical protein	NA	NA	NA	NA
WP_073537025.1\|43885_44287_-	hypothetical protein	NA	NA	NA	NA
WP_083585612.1\|44283_46545_-	DNA primase	A0A1U9ZA69	Proteus_phage	3.5e-19	28.4
WP_073537027.1\|46492_46717_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_083585613.1\|46910_47735_-	hypothetical protein	A0A090DCZ8	Clostridium_phage	1.1e-05	38.4
WP_073537029.1\|47712_47922_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073537030.1\|48098_48671_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073537031.1\|48843_50007_+\|integrase	site-specific integrase	X5JB41	Clostridium_phage	1.9e-24	28.8
WP_073537032.1\|50285_51443_-\|integrase	site-specific integrase	A0A2H4JCB7	uncultured_Caudovirales_phage	4.3e-37	31.6
55396:55411	attR	NA	NA	NA	NA

DBSCAN-SWA_2

60296 : 70147

Aeribacillus_phage(22.22%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_156875979.1\|60296_60566_+	hypothetical protein	A0A2H4JG91	uncultured_Caudovirales_phage	1.6e-16	47.7
WP_073537054.1\|60576_62565_+	AAA family ATPase	A0A1L2K2K3	Aeribacillus_phage	5.4e-88	32.6
WP_073537055.1\|62591_63524_+	recombinase RecT	A0A1L2JY28	Aeribacillus_phage	1.9e-59	46.1
WP_073537056.1\|63523_64249_+	MBL fold metallo-hydrolase	A8ATK9	Listeria_phage	7.0e-62	49.1
WP_073537057.1\|64262_65081_+	hypothetical protein	A0A0A7RWV8	Clostridium_phage	2.3e-37	63.1
WP_073537058.1\|65010_65880_+	ATP-binding protein	A0A2K9V3L7	Faecalibacterium_phage	1.9e-29	34.9
WP_073537059.1\|65898_66726_+	DNA adenine methylase	U5P0W8	Brevibacillus_phage	4.6e-41	37.8
WP_073537060.1\|66740_67166_+	hypothetical protein	NA	NA	NA	NA
WP_073541010.1\|67188_68610_+	DNA cytosine methyltransferase	A0A1I9KFD6	Aeromonas_phage	8.5e-128	54.8
WP_073537061.1\|68909_69638_+	hypothetical protein	NA	NA	NA	NA
WP_073537062.1\|69634_70147_+	hypothetical protein	A0A2K9V425	Faecalibacterium_phage	4.8e-33	49.7

DBSCAN-SWA_3

77022 : 113255

uncultured_Caudovirales_phage(35.71%)

tail,holin,portal,terminase,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073537072.1\|77022_78432_+\|terminase	terminase B	B6SBS6	Clostridium_virus	2.6e-214	76.8
WP_073537073.1\|78422_79943_+\|portal	phage portal protein	A0A0A8WI73	Clostridium_phage	6.4e-198	68.5
WP_073537074.1\|79935_81267_+	hypothetical protein	A0A0A8WIZ2	Clostridium_phage	3.4e-94	49.7
WP_073537075.1\|81272_81497_+	hypothetical protein	NA	NA	NA	NA
WP_073537076.1\|81563_81980_+	hypothetical protein	D9ZNC9	Clostridium_phage	4.4e-08	35.1
WP_073537077.1\|82127_83603_+	hypothetical protein	A0A0A8WFF1	Clostridium_phage	6.1e-121	54.3
WP_073537078.1\|83618_83996_+	DUF2190 family protein	A0A0N7ACR5	Bacillus_phage	8.5e-19	47.8
WP_073537079.1\|84011_85046_+	aspartate ammonia-lyase	A0A0A8WEW9	Clostridium_phage	1.1e-103	54.4
WP_073537080.1\|85091_85421_+	hypothetical protein	B6SBT2	Clostridium_virus	3.8e-23	45.5
WP_073537081.1\|85417_85801_+	hypothetical protein	B6SBT3	Clostridium_virus	2.8e-25	46.0
WP_073537082.1\|85776_86211_+	hypothetical protein	A0A2H4J736	uncultured_Caudovirales_phage	1.6e-32	51.2
WP_073537083.1\|86215_86470_+	hypothetical protein	NA	NA	NA	NA
WP_073537084.1\|86454_87282_+	hypothetical protein	A0A2H4J4Q0	uncultured_Caudovirales_phage	1.9e-71	50.9
WP_073537085.1\|87286_87640_+	hypothetical protein	A0A2H4J7J8	uncultured_Caudovirales_phage	3.7e-08	50.9
WP_073537086.1\|87640_89059_+\|tail	phage tail sheath protein	A0A2H4J1N7	uncultured_Caudovirales_phage	1.1e-143	52.8
WP_073537087.1\|89077_89494_+\|tail	phage tail tube protein	A0A2H4J032	uncultured_Caudovirales_phage	1.1e-48	68.2
WP_073537088.1\|89728_90184_+	hypothetical protein	A0A2H4J883	uncultured_Caudovirales_phage	1.6e-27	49.3
WP_073537089.1\|90474_91314_+	hypothetical protein	NA	NA	NA	NA
WP_073537090.1\|91520_92234_+	Rha family transcriptional regulator	B5TRB0	Bacteroides_phage	1.3e-23	52.3
WP_073537091.1\|92274_92928_-	hypothetical protein	NA	NA	NA	NA
WP_083585615.1\|93221_93914_-	helix-turn-helix domain-containing protein	I2E8Y1	Clostridium_phage	5.2e-06	35.7
WP_073537093.1\|93968_94178_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073537094.1\|94290_95103_+	hypothetical protein	A0A0F6N3N8	Staphylococcus_phage	1.2e-25	37.6
WP_083585616.1\|95104_96142_+	hypothetical protein	A0A2R2ZGW3	Clostridioides_phage	1.4e-26	57.1
WP_073537095.1\|96411_96933_-	hypothetical protein	NA	NA	NA	NA
WP_073537096.1\|97146_102099_+	tape measure protein	A0A1L2JY60	Aeribacillus_phage	3.6e-40	53.3
WP_073537097.1\|102372_102579_-	hypothetical protein	NA	NA	NA	NA
WP_073537098.1\|102659_102998_+	hypothetical protein	NA	NA	NA	NA
WP_073537099.1\|103014_103215_+	hypothetical protein	NA	NA	NA	NA
WP_156875983.1\|103276_103471_+	hypothetical protein	NA	NA	NA	NA
WP_073537101.1\|103603_104359_+	hypothetical protein	A0A2H4J045	uncultured_Caudovirales_phage	2.4e-65	54.6
WP_073537102.1\|104367_105351_+	XkdQ	A0A2H4J063	uncultured_Caudovirales_phage	7.0e-97	55.8
WP_073537103.1\|105325_105655_+	hypothetical protein	A0A0A8WFG6	Clostridium_phage	1.0e-20	48.1
WP_073537104.1\|105655_106114_+	DUF2634 domain-containing protein	A0A2H4J4Q8	uncultured_Caudovirales_phage	1.3e-40	53.9
WP_073537105.1\|106118_107243_+\|plate	baseplate J/gp47 family protein	A0A2H4J7K8	uncultured_Caudovirales_phage	1.5e-71	43.3
WP_012103584.1\|109622_110243_+	YmfQ family protein	A0A0A7RTU9	Clostridium_phage	3.1e-74	61.2
WP_073537106.1\|110254_111940_+	hypothetical protein	S6B1J7	Thermus_phage	1.4e-23	31.6
WP_012103582.1\|111953_112298_+	hypothetical protein	NA	NA	NA	NA
WP_073537107.1\|112314_112455_+	XkdX family protein	NA	NA	NA	NA
WP_073537108.1\|112522_112747_+	hypothetical protein	NA	NA	NA	NA
WP_083585802.1\|112943_113255_+\|holin	phage holin family protein	A0A0E3Y658	Fusobacterium_phage	2.0e-18	53.0

DBSCAN-SWA_4

455117 : 498588

Bacillus_phage(42.86%)

protease,transposase,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073537394.1\|455117_456800_-\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_083585806.1\|457188_457854_+	hypothetical protein	F8WPS9	Bacillus_phage	6.5e-22	54.2
WP_073537396.1\|457876_458518_+	DUF2625 family protein	NA	NA	NA	NA
WP_073537397.1\|459006_459414_+	SMI1/KNR4 family protein	NA	NA	NA	NA
WP_073541045.1\|461496_461967_+	hypothetical protein	NA	NA	NA	NA
WP_073537398.1\|461978_462527_+	DUF1851 domain-containing protein	NA	NA	NA	NA
WP_073537400.1\|463063_463354_-	hypothetical protein	NA	NA	NA	NA
WP_073537401.1\|463659_465318_+	hypothetical protein	A0A2H4J389	uncultured_Caudovirales_phage	7.3e-22	38.2
WP_073537402.1\|465322_465739_+	hypothetical protein	A0A2H4J4V0	uncultured_Caudovirales_phage	2.1e-26	39.7
WP_073537403.1\|466230_466593_+	hypothetical protein	NA	NA	NA	NA
WP_156875988.1\|466690_466942_+	hypothetical protein	NA	NA	NA	NA
WP_073537405.1\|466980_467259_+	DUF4176 domain-containing protein	NA	NA	NA	NA
WP_073537406.1\|467407_467662_+	hypothetical protein	NA	NA	NA	NA
WP_073537407.1\|467869_468355_+	hypothetical protein	NA	NA	NA	NA
WP_073537408.1\|468360_469596_+	hypothetical protein	NA	NA	NA	NA
WP_073537409.1\|469676_470051_+	BlaI/MecI/CopY family transcriptional regulator	A0A2R2ZGM0	Clostridioides_phage	8.7e-08	35.5
WP_156875989.1\|470070_472119_+\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_073537410.1\|472177_473167_+	DUF4362 domain-containing protein	NA	NA	NA	NA
WP_073537411.1\|473424_475581_+	PTS sugar transporter subunit IIC/EAL domain-containing protein	NA	NA	NA	NA
WP_073537412.1\|475700_476279_-	cyclase	NA	NA	NA	NA
WP_073537413.1\|476440_476938_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_073537414.1\|476976_477177_+	hypothetical protein	NA	NA	NA	NA
WP_083585625.1\|477721_477985_+	hypothetical protein	NA	NA	NA	NA
WP_156875990.1\|478590_478758_-	hypothetical protein	NA	NA	NA	NA
WP_156875991.1\|479388_479940_+	hypothetical protein	NA	NA	NA	NA
WP_073537417.1\|480102_480762_+	response regulator transcription factor	W8CYM9	Bacillus_phage	3.6e-41	40.7
WP_073537418.1\|480862_482116_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_073537419.1\|482518_484012_+	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	4.7e-28	29.4
WP_083585626.1\|484219_484333_-	hypothetical protein	NA	NA	NA	NA
WP_083585627.1\|484528_484786_-\|transposase	transposase	NA	NA	NA	NA
WP_073537420.1\|484810_484990_-\|transposase	transposase	NA	NA	NA	NA
WP_073537421.1\|485050_485470_+	hypothetical protein	NA	NA	NA	NA
WP_083585628.1\|485454_486711_+	DUF4179 domain-containing protein	NA	NA	NA	NA
WP_073541051.1\|486886_487897_-	AI-2E family transporter	NA	NA	NA	NA
WP_073537423.1\|488265_488457_-	hypothetical protein	NA	NA	NA	NA
WP_083585630.1\|489166_490552_+	hypothetical protein	NA	NA	NA	NA
WP_073541055.1\|490621_491203_+	DUF4194 domain-containing protein	NA	NA	NA	NA
WP_083585631.1\|491171_494408_+	AAA family ATPase	NA	NA	NA	NA
WP_073537425.1\|494394_495612_+	hypothetical protein	NA	NA	NA	NA
WP_083585632.1\|495887_496088_+	hypothetical protein	NA	NA	NA	NA
WP_073537426.1\|496062_496491_+	redox-active protein	NA	NA	NA	NA
WP_073537427.1\|497166_497391_+	hypothetical protein	NA	NA	NA	NA
WP_083585633.1\|497329_498010_+	hypothetical protein	NA	NA	NA	NA
WP_083585634.1\|498324_498588_+\|holin	phage holin family protein	M9Q253	Clostridium_phage	8.3e-13	46.7

DBSCAN-SWA_5

702494 : 747470

Bacillus_phage(25.0%)

transposase,terminase,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073537605.1\|702494_703673_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_073537606.1\|703803_704619_-	protein-glutamate O-methyltransferase CheR	NA	NA	NA	NA
WP_073537608.1\|704678_706541_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	3.9e-08	64.7
WP_156875997.1\|708602_709094_-	chemotaxis protein CheW	NA	NA	NA	NA
WP_073537612.1\|709108_711175_-	chemotaxis protein CheA	NA	NA	NA	NA
WP_073537613.1\|711209_711572_-	response regulator	Q6XM27	Feldmannia_irregularis_virus	3.2e-07	31.4
WP_156875998.1\|712119_712260_+	hypothetical protein	NA	NA	NA	NA
WP_156875999.1\|712746_712917_-	hypothetical protein	NA	NA	NA	NA
WP_073537614.1\|712968_713391_-	DUF2000 domain-containing protein	NA	NA	NA	NA
WP_073537615.1\|713537_714362_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_073537616.1\|716328_716634_+	hypothetical protein	NA	NA	NA	NA
WP_073537617.1\|716633_717011_+	hypothetical protein	NA	NA	NA	NA
WP_073537618.1\|718424_719114_+	DUF421 domain-containing protein	NA	NA	NA	NA
WP_073537619.1\|720550_721168_-	hypothetical protein	NA	NA	NA	NA
WP_083585645.1\|721183_721777_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_083585646.1\|722009_722366_-	cupin domain-containing protein	NA	NA	NA	NA
WP_073537622.1\|722397_723066_-	hypothetical protein	NA	NA	NA	NA
WP_073537623.1\|723201_724605_+	PLP-dependent aminotransferase family protein	NA	NA	NA	NA
WP_073537624.1\|725421_725985_+	isoprenylcysteine carboxylmethyltransferase family protein	NA	NA	NA	NA
WP_073537625.1\|726556_727258_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.2e-34	38.5
WP_073537626.1\|727241_728693_+	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	1.4e-32	31.5
WP_073537627.1\|728778_730134_+	hypothetical protein	NA	NA	NA	NA
WP_083585647.1\|730218_731088_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_156876000.1\|731077_731227_-	hypothetical protein	NA	NA	NA	NA
WP_073537628.1\|731367_731616_-\|transposase	IS3 family transposase	A0A0C5AEB1	Paenibacillus_phage	4.3e-11	48.6
WP_073537629.1\|731792_732320_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_073537631.1\|733537_734068_+	signal peptidase II	NA	NA	NA	NA
WP_083585807.1\|735087_735735_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_073537632.1\|736729_737659_+	DUF2935 domain-containing protein	NA	NA	NA	NA
WP_073541089.1\|737924_738209_+	hypothetical protein	NA	NA	NA	NA
WP_073537633.1\|738610_738931_+\|terminase	terminase small subunit	A0A141E1Y3	Streptococcus_phage	5.7e-08	42.3
WP_073537634.1\|739486_740179_+	radical SAM protein	NA	NA	NA	NA
WP_073537635.1\|740324_740696_+	DUF1232 domain-containing protein	NA	NA	NA	NA
WP_073537636.1\|740773_741178_+\|holin	phage holin family protein	D9ZNF2	Clostridium_phage	7.7e-34	57.6
WP_073537637.1\|741174_741519_+	glycoside hydrolase family 25 protein	D9ZNF3	Clostridium_phage	1.5e-30	56.2
WP_073537638.1\|741498_741966_-	hypothetical protein	NA	NA	NA	NA
WP_073537640.1\|742654_743347_+	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_073537641.1\|743343_743598_-	hypothetical protein	NA	NA	NA	NA
WP_156876001.1\|744034_744490_-	hypothetical protein	NA	NA	NA	NA
WP_073537643.1\|744681_745857_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_073537418.1\|746216_747470_+\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_6

1830414 : 1876821

Bacillus_phage(55.56%)

protease,transposase,integrase

attL 1844554:1844571|attR 1881679:1881696

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073538516.1\|1830414_1831257_+\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_083585675.1\|1831330_1832029_+	response regulator transcription factor	W8CYM9	Bacillus_phage	2.0e-34	36.3
WP_073538518.1\|1832030_1833416_+	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	1.9e-39	33.8
WP_073538519.1\|1833465_1834173_-	bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE	NA	NA	NA	NA
WP_073538520.1\|1834188_1834809_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_073538521.1\|1834813_1835722_-	1,4-dihydroxy-2-naphthoate octaprenyltransferase	NA	NA	NA	NA
WP_073538522.1\|1835793_1837176_-	4Fe-4S binding protein	NA	NA	NA	NA
WP_073538523.1\|1837194_1837728_-	FixH family protein	NA	NA	NA	NA
WP_073541213.1\|1837984_1838791_-	polyprenyl synthetase family protein	NA	NA	NA	NA
WP_073538524.1\|1839123_1839933_+	electron transfer flavoprotein subunit beta/FixA family protein	NA	NA	NA	NA
WP_073538525.1\|1839920_1841219_+	4Fe-4S dicluster domain-containing protein	NA	NA	NA	NA
WP_073538526.1\|1841211_1842507_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_083585676.1\|1842506_1842800_+	4Fe-4S ferredoxin	NA	NA	NA	NA
WP_073538527.1\|1843309_1844893_-	FMN-binding protein	NA	NA	NA	NA
1844554:1844571	attL	NA	NA	NA	NA
WP_073538528.1\|1844889_1845849_-	FAD:protein FMN transferase	NA	NA	NA	NA
WP_073538529.1\|1846161_1847346_-	MFS transporter	NA	NA	NA	NA
WP_073538530.1\|1847565_1847901_-	hypothetical protein	NA	NA	NA	NA
WP_156876128.1\|1849379_1850399_+	glycoside hydrolase	A0A1V0DZX6	Clostridioides_phage	1.0e-21	48.3
WP_073538532.1\|1850560_1850821_+	hypothetical protein	NA	NA	NA	NA
WP_073538533.1\|1851164_1851473_+	hypothetical protein	NA	NA	NA	NA
WP_073538534.1\|1851796_1852165_+	YHS domain-containing protein	NA	NA	NA	NA
WP_073538535.1\|1852263_1852497_+	hypothetical protein	NA	NA	NA	NA
WP_073538536.1\|1852733_1854968_+	copper-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	2.4e-113	35.8
WP_073538537.1\|1855008_1855224_+	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_073538538.1\|1855604_1856276_+	response regulator transcription factor	W8CYM9	Bacillus_phage	9.1e-40	37.1
WP_073538539.1\|1856272_1857700_+	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_073538540.1\|1857836_1858301_+	hypothetical protein	NA	NA	NA	NA
WP_156876021.1\|1858425_1859834_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.6e-54	43.8
WP_073538544.1\|1860506_1860743_+	hypothetical protein	NA	NA	NA	NA
WP_073538545.1\|1860997_1861603_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_073538546.1\|1862049_1864857_+	cell wall-binding repeat-containing protein	NA	NA	NA	NA
WP_073538547.1\|1865032_1866202_+	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_073538548.1\|1866594_1867779_-\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	7.0e-27	25.6
WP_073538549.1\|1868176_1869442_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_083585678.1\|1869793_1870168_+	hypothetical protein	NA	NA	NA	NA
WP_083585679.1\|1870152_1870542_+	hypothetical protein	NA	NA	NA	NA
WP_073538550.1\|1870541_1871525_+	SagB/ThcOx family dehydrogenase	NA	NA	NA	NA
WP_073538551.1\|1871568_1875150_+	AMP-binding protein	A0A1V0SBX8	Catovirus	2.9e-15	23.3
WP_073538552.1\|1875393_1876821_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A1X9I6E7	Streptococcus_phage	9.1e-05	29.8
1881679:1881696	attR	NA	NA	NA	NA

DBSCAN-SWA_7

2061916 : 2154964

Planktothrix_phage(25.0%)

protease,transposase,integrase,coat

attL 2114408:2114423|attR 2123829:2123844

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073538687.1\|2061916_2062672_+\|protease	serine protease	A0A0E3T7R5	Bacillus_phage	9.0e-36	62.8
WP_073538688.1\|2062895_2063999_-	hypothetical protein	NA	NA	NA	NA
WP_073538689.1\|2067050_2067809_-	Fic family protein	Q9AZ49	Lactococcus_phage	1.3e-05	27.5
WP_083585692.1\|2067887_2068562_-	CRISPR-associated endoribonuclease Cas6	NA	NA	NA	NA
WP_073538691.1\|2068743_2069910_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	Q332B3	Clostridium_botulinum_C_phage	3.2e-88	47.4
WP_073538692.1\|2069902_2070511_-\|transposase	IS607 family transposase	Q331Z3	Clostridium_botulinum_C_phage	1.3e-48	52.0
WP_073538693.1\|2071104_2071368_-	CRISPR-associated endonuclease Cas2	NA	NA	NA	NA
WP_073538694.1\|2071370_2072363_-	type I-B CRISPR-associated endonuclease Cas1	NA	NA	NA	NA
WP_083585693.1\|2072383_2072875_-	CRISPR-associated protein Cas4	NA	NA	NA	NA
WP_073538696.1\|2075401_2076373_-	hypothetical protein	NA	NA	NA	NA
WP_012102036.1\|2076377_2076704_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_073538697.1\|2076994_2078245_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_073538698.1\|2078251_2078947_-	response regulator transcription factor	W8CYM9	Bacillus_phage	9.2e-27	32.3
WP_073538699.1\|2079014_2081555_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_073538700.1\|2081579_2082254_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.9e-33	34.1
WP_073538701.1\|2082666_2083290_+	LexA family transcriptional regulator	G3MBD2	Bacillus_virus	1.4e-10	53.7
WP_073538702.1\|2083322_2083706_-	hypothetical protein	NA	NA	NA	NA
WP_073538703.1\|2083702_2084782_-	radical SAM protein	NA	NA	NA	NA
WP_073538704.1\|2085069_2085765_-	DUF3298 domain-containing protein	NA	NA	NA	NA
WP_073538705.1\|2085828_2087301_-	MFS transporter	NA	NA	NA	NA
WP_073538706.1\|2087297_2087759_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_073538707.1\|2087904_2088990_+	DNA helicase UvrC	NA	NA	NA	NA
WP_073538708.1\|2089078_2089807_-	ethanolamine ammonia-lyase subunit EutC	NA	NA	NA	NA
WP_073538709.1\|2089819_2091190_-	ethanolamine ammonia-lyase subunit EutB	NA	NA	NA	NA
WP_073538710.1\|2091214_2092549_-	ethanolamine permease	NA	NA	NA	NA
WP_083585694.1\|2092590_2094003_-	ethanolamine ammonia-lyase reactivating factor EutA	NA	NA	NA	NA
WP_073538712.1\|2094409_2095825_-	histidine kinase	NA	NA	NA	NA
WP_073538713.1\|2095831_2096407_-	response regulator	Q6XM27	Feldmannia_irregularis_virus	1.9e-06	33.9
WP_073538714.1\|2096557_2097589_-	epoxyqueuosine reductase	NA	NA	NA	NA
WP_073538715.1\|2097657_2098095_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_073538716.1\|2098187_2098367_-	hypothetical protein	NA	NA	NA	NA
WP_073538717.1\|2098482_2099799_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_073538718.1\|2099869_2100013_-	cyclic lactone autoinducer peptide	NA	NA	NA	NA
WP_083585817.1\|2100167_2100347_+	hypothetical protein	NA	NA	NA	NA
WP_073541246.1\|2100348_2100912_-	Uma2 family endonuclease	NA	NA	NA	NA
WP_073538719.1\|2103317_2104706_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	NA	NA	NA	NA
WP_156876025.1\|2105450_2105759_-	hypothetical protein	NA	NA	NA	NA
WP_073541248.1\|2105793_2106417_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_073538721.1\|2106509_2106848_-	ArsC family transcriptional regulator	NA	NA	NA	NA
WP_073538722.1\|2106860_2108183_-	ABC transporter permease	NA	NA	NA	NA
WP_073538723.1\|2108196_2109516_-	ABC transporter permease	NA	NA	NA	NA
WP_073538724.1\|2109505_2110186_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.1e-35	41.9
WP_083585695.1\|2111051_2113304_-	ABC transporter permease	NA	NA	NA	NA
WP_073538726.1\|2113297_2113996_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.3e-32	33.2
WP_083585696.1\|2114011_2114713_-	TetR family transcriptional regulator	NA	NA	NA	NA
2114408:2114423	attL	NA	NA	NA	NA
WP_073538728.1\|2115040_2115439_+	hypothetical protein	NA	NA	NA	NA
WP_073538729.1\|2115484_2116072_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	5.3e-44	49.2
WP_073538730.1\|2116091_2116484_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073538731.1\|2116661_2116883_-	hypothetical protein	NA	NA	NA	NA
WP_073538732.1\|2116964_2117231_-\|transposase	transposase	NA	NA	NA	NA
WP_073538733.1\|2117426_2118188_-	imidazole glycerol phosphate synthase subunit HisF	NA	NA	NA	NA
WP_073538734.1\|2118383_2119004_-	imidazole glycerol phosphate synthase subunit HisH	NA	NA	NA	NA
WP_083585697.1\|2119410_2119854_+	cobalamin B12-binding domain-containing protein	NA	NA	NA	NA
WP_073538736.1\|2119957_2120851_-\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_073538737.1\|2120870_2121575_+	hypothetical protein	NA	NA	NA	NA
WP_156876026.1\|2121513_2122188_+	hypothetical protein	NA	NA	NA	NA
WP_073538739.1\|2122190_2123129_+	DMT family transporter	NA	NA	NA	NA
WP_083585698.1\|2123462_2123609_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_073538740.1\|2124018_2124702_+\|transposase	transposase	NA	NA	NA	NA
2123829:2123844	attR	NA	NA	NA	NA
WP_073538741.1\|2124924_2125671_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_073537418.1\|2127136_2128390_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_073538742.1\|2128528_2129806_-	hypothetical protein	NA	NA	NA	NA
WP_073538743.1\|2129856_2130504_-	hypothetical protein	NA	NA	NA	NA
WP_073538744.1\|2130533_2132861_-	hypothetical protein	NA	NA	NA	NA
WP_073538745.1\|2132912_2136323_-	hypothetical protein	NA	NA	NA	NA
WP_073538746.1\|2136359_2138102_-	VWA domain-containing protein	NA	NA	NA	NA
WP_073538747.1\|2138104_2139556_-	hypothetical protein	NA	NA	NA	NA
WP_073538748.1\|2139597_2142261_-	hypothetical protein	NA	NA	NA	NA
WP_073538749.1\|2142270_2143449_-	hypothetical protein	NA	NA	NA	NA
WP_073538750.1\|2143485_2144490_-	hypothetical protein	NA	NA	NA	NA
WP_073538751.1\|2144528_2144873_-	hypothetical protein	NA	NA	NA	NA
WP_012102068.1\|2145182_2145443_-\|coat	spore coat protein	NA	NA	NA	NA
WP_073538752.1\|2145463_2145670_-	hypothetical protein	NA	NA	NA	NA
WP_073538753.1\|2145819_2146665_-	DUF1129 family protein	NA	NA	NA	NA
WP_073538754.1\|2146657_2146996_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_073538755.1\|2147298_2147676_+	PH domain-containing protein	A6N235	Microbacterium_phage	3.5e-12	34.5
WP_073538756.1\|2147804_2148461_+	VanZ family protein	NA	NA	NA	NA
WP_073538757.1\|2148979_2149522_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_073538758.1\|2149522_2150740_+	DUF4179 domain-containing protein	NA	NA	NA	NA
WP_073538759.1\|2150877_2151480_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_073538760.1\|2152058_2152343_-	response regulator transcription factor	NA	NA	NA	NA
WP_156876027.1\|2152382_2153282_-	hypothetical protein	NA	NA	NA	NA
WP_073537418.1\|2153710_2154964_-\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_8

2484724 : 2522783

Clostridium_phage(26.32%)

transposase,head,integrase,protease,capsid,portal,terminase

attL 2490251:2490265|attR 2515463:2515477

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073539027.1\|2484724_2485969_-\|capsid	phage major capsid protein	NA	NA	NA	NA
WP_073539028.1\|2485983_2486670_-\|head,protease	HK97 family phage prohead protease	U5U3W0	Lactobacillus_phage	5.7e-13	34.2
WP_083585710.1\|2486691_2487018_-	hypothetical protein	K4FBB5	Cronobacter_phage	5.8e-16	47.7
WP_083585711.1\|2487195_2488431_-\|portal	phage portal protein	A0A0P0IZM3	Lactobacillus_phage	1.5e-24	24.7
WP_073539031.1\|2488443_2490174_-\|terminase	terminase large subunit	A0A290GJW3	Caldibacillus_phage	1.0e-82	33.6
WP_073539032.1\|2490166_2490535_-	hypothetical protein	A0A290GJQ7	Caldibacillus_phage	3.5e-17	45.1
2490251:2490265	attL	NA	NA	NA	NA
WP_073539033.1\|2490673_2490952_-	restriction endonuclease	R9TNN2	Paenibacillus_phage	6.3e-11	44.0
WP_083585712.1\|2491229_2491637_-	hypothetical protein	NA	NA	NA	NA
WP_073539034.1\|2492267_2492819_-	hypothetical protein	NA	NA	NA	NA
WP_073539035.1\|2492856_2493504_-	hypothetical protein	A0A2H4J8I2	uncultured_Caudovirales_phage	1.6e-25	36.1
WP_073539036.1\|2493515_2493719_-	hypothetical protein	NA	NA	NA	NA
WP_073539037.1\|2493719_2494037_-	hypothetical protein	NA	NA	NA	NA
WP_073539038.1\|2494117_2494432_-	hypothetical protein	NA	NA	NA	NA
WP_073539039.1\|2494445_2495165_-	hypothetical protein	A0A0A7RUC6	Clostridium_phage	2.5e-96	73.8
WP_073539040.1\|2495192_2495588_-	replication terminator protein	A0A0A7RUF3	Clostridium_phage	1.5e-34	53.4
WP_073541289.1\|2495600_2495972_-	RusA family crossover junction endodeoxyribonuclease	A0A0A8WJX1	Clostridium_phage	6.4e-27	49.6
WP_073539041.1\|2496007_2496508_-	hypothetical protein	NA	NA	NA	NA
WP_073539042.1\|2496507_2496738_-	hypothetical protein	NA	NA	NA	NA
WP_073539043.1\|2496861_2497341_-	hypothetical protein	NA	NA	NA	NA
WP_073539044.1\|2497378_2498383_-	DNA (cytosine-5-)-methyltransferase	D2IZY5	Enterococcus_phage	4.8e-93	54.1
WP_073539045.1\|2498385_2498616_-	hypothetical protein	NA	NA	NA	NA
WP_073539046.1\|2498651_2498903_-	hypothetical protein	NA	NA	NA	NA
WP_073539047.1\|2498899_2499340_-	hypothetical protein	NA	NA	NA	NA
WP_073539048.1\|2499488_2500784_-	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	7.6e-75	40.0
WP_073539049.1\|2500789_2501653_-	DnaD domain protein	D2JGK4	Staphylococcus_phage	3.8e-30	55.7
WP_073539050.1\|2501663_2502458_-	hypothetical protein	A0A0A7RUC1	Clostridium_phage	5.7e-57	46.6
WP_073539051.1\|2502457_2503354_-	hypothetical protein	A0A0A7RW37	Clostridium_phage	5.1e-70	53.3
WP_073539052.1\|2503346_2505005_-	hypothetical protein	R9TQJ2	Paenibacillus_phage	9.6e-115	41.6
WP_073539053.1\|2505182_2505509_-	hypothetical protein	NA	NA	NA	NA
WP_073539054.1\|2505522_2506242_-	hypothetical protein	NA	NA	NA	NA
WP_073539055.1\|2506334_2506634_-	hypothetical protein	NA	NA	NA	NA
WP_073539056.1\|2506636_2507071_-	hypothetical protein	NA	NA	NA	NA
WP_073539057.1\|2507073_2507310_-	hypothetical protein	NA	NA	NA	NA
WP_156876040.1\|2507310_2507472_-	hypothetical protein	NA	NA	NA	NA
WP_073539058.1\|2507484_2507826_-	hypothetical protein	NA	NA	NA	NA
WP_073539059.1\|2508065_2508281_-	hypothetical protein	NA	NA	NA	NA
WP_073539060.1\|2508264_2508645_-	hypothetical protein	NA	NA	NA	NA
WP_073539061.1\|2508769_2509177_-	hypothetical protein	A0A2H4J7N9	uncultured_Caudovirales_phage	6.8e-06	29.7
WP_073541291.1\|2509480_2509672_-	hypothetical protein	NA	NA	NA	NA
WP_073539062.1\|2509772_2509988_-	hypothetical protein	NA	NA	NA	NA
WP_156876041.1\|2509991_2510156_-	hypothetical protein	NA	NA	NA	NA
WP_073539064.1\|2510470_2511232_-	Rha family transcriptional regulator	A0A2I6PD87	Staphylococcus_phage	1.6e-40	38.4
WP_083585714.1\|2511251_2511551_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073539066.1\|2511498_2511702_-	hypothetical protein	NA	NA	NA	NA
WP_156876042.1\|2511787_2512003_-	hypothetical protein	NA	NA	NA	NA
WP_073539068.1\|2512263_2512686_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_156876043.1\|2512687_2512828_-	hypothetical protein	NA	NA	NA	NA
WP_073539069.1\|2513080_2513332_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073539071.1\|2513663_2514755_+\|integrase	site-specific integrase	A8ATX2	Listeria_phage	2.1e-33	31.9
WP_073541304.1\|2516777_2517125_+	HNH endonuclease	NA	NA	NA	NA
2515463:2515477	attR	NA	NA	NA	NA
WP_073539073.1\|2517139_2517355_+	hypothetical protein	NA	NA	NA	NA
WP_073539074.1\|2517765_2517966_+	hypothetical protein	NA	NA	NA	NA
WP_073539075.1\|2517980_2518439_+	hypothetical protein	NA	NA	NA	NA
WP_073539078.1\|2519840_2520335_+	SMI1/KNR4 family protein	NA	NA	NA	NA
WP_073539079.1\|2521997_2522783_+\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_9

2965536 : 3024499

Bacillus_phage(25.0%)

protease,transposase,head

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073539419.1\|2965536_2965839_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	NA	NA	NA	NA
WP_073539420.1\|2965907_2966537_-\|transposase	IS607 family transposase	I7JC24	Campylobacter_virus	4.7e-46	45.8
WP_083585736.1\|2966602_2966836_-	hypothetical protein	NA	NA	NA	NA
WP_073539422.1\|2966991_2967765_+	enoyl-CoA hydratase	NA	NA	NA	NA
WP_073539423.1\|2967915_2968119_+	alpha/beta-type small acid-soluble spore protein	NA	NA	NA	NA
WP_073539424.1\|2968701_2970942_-	AAA family ATPase	NA	NA	NA	NA
WP_073539425.1\|2971159_2971840_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073539426.1\|2971854_2972967_-	acyltransferase	NA	NA	NA	NA
WP_073539427.1\|2973493_2973769_+	hypothetical protein	NA	NA	NA	NA
WP_073539428.1\|2974762_2976148_-\|transposase	IS4 family transposase	Q9JMP3	Wolbachia_phage	4.4e-81	39.1
WP_073539429.1\|2976537_2977422_-	amidohydrolase	NA	NA	NA	NA
WP_073539430.1\|2977435_2978662_-	amidohydrolase family protein	NA	NA	NA	NA
WP_156876055.1\|2978764_2980014_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	8.0e-13	31.7
WP_073539433.1\|2980231_2981287_-	HAMP domain-containing sensor histidine kinase	W8CYF6	Bacillus_phage	3.6e-67	42.9
WP_073539434.1\|2981283_2981961_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.5e-74	58.3
WP_073539435.1\|2982323_2982947_-	hypothetical protein	NA	NA	NA	NA
WP_073539436.1\|2983074_2983875_-	hypothetical protein	NA	NA	NA	NA
WP_073539437.1\|2983877_2984210_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_073539438.1\|2984658_2985219_-	metal-iron-binding protein	NA	NA	NA	NA
WP_073539439.1\|2985941_2987153_-	HDOD domain-containing protein	NA	NA	NA	NA
WP_073539441.1\|2987773_2988757_-	DMT family transporter	NA	NA	NA	NA
WP_073539442.1\|2989004_2989463_-	hypothetical protein	NA	NA	NA	NA
WP_073539443.1\|2989697_2990216_-	hypothetical protein	NA	NA	NA	NA
WP_073539444.1\|2992033_2993089_-	histidinol-phosphate transaminase	NA	NA	NA	NA
WP_073539445.1\|2994202_2994538_-	hypothetical protein	NA	NA	NA	NA
WP_073539446.1\|2995050_2995590_-	nitroreductase	NA	NA	NA	NA
WP_073539447.1\|2995641_2996250_-	transglutaminase family protein	NA	NA	NA	NA
WP_073539448.1\|2996376_2996943_-	nitroreductase	NA	NA	NA	NA
WP_073539449.1\|2997057_2997324_-	hypothetical protein	NA	NA	NA	NA
WP_073539450.1\|2997380_2997815_-	hypothetical protein	NA	NA	NA	NA
WP_156876056.1\|2998046_2998211_-	hypothetical protein	NA	NA	NA	NA
WP_073539451.1\|2998332_2998533_-	hypothetical protein	NA	NA	NA	NA
WP_156876137.1\|2998581_2998701_-	hypothetical protein	NA	NA	NA	NA
WP_073539452.1\|2998887_2999787_-	FMN-binding protein	NA	NA	NA	NA
WP_073539453.1\|3000116_3004616_-	AAA family ATPase	NA	NA	NA	NA
WP_073539454.1\|3005548_3008176_-	phosphoenolpyruvate synthase	A0A1V0SGR7	Hokovirus	5.3e-43	29.1
WP_073539455.1\|3008223_3008820_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_073539456.1\|3009166_3010537_-	serine hydrolase	A0A2H4PBG0	Mycobacterium_phage	2.9e-16	27.2
WP_073539459.1\|3014377_3014929_-	histidine phosphatase family protein	NA	NA	NA	NA
WP_156876057.1\|3016165_3016342_-	hypothetical protein	NA	NA	NA	NA
WP_156876058.1\|3016650_3016797_-	hypothetical protein	NA	NA	NA	NA
WP_073539461.1\|3016896_3017334_-	hypothetical protein	NA	NA	NA	NA
WP_073539462.1\|3017363_3018968_-	hypothetical protein	NA	NA	NA	NA
WP_073539463.1\|3019303_3019591_-	hypothetical protein	NA	NA	NA	NA
WP_073539464.1\|3019657_3020404_-\|protease	protease inhibitor I42 family protein	NA	NA	NA	NA
WP_073539467.1\|3021554_3022370_-	hypothetical protein	NA	NA	NA	NA
WP_073539469.1\|3024172_3024499_-\|head	phage head closure protein	A0A0A7RUH8	Clostridium_phage	1.7e-20	46.8

DBSCAN-SWA_10

3034840 : 3069893

Streptococcus_phage(21.74%)

tail,transposase,head,capsid,portal,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073539481.1\|3034840_3036697_-	hypothetical protein	A0A0A7RUI9	Clostridium_phage	8.1e-54	40.3
WP_073539482.1\|3036696_3037404_-\|tail	phage tail protein	A0A1L2BYA2	Clostridium_phage	3.0e-17	26.5
WP_073539483.1\|3037405_3039847_-\|tail	phage tail tape measure protein	A8ATH6	Listeria_phage	2.9e-51	46.2
WP_073539484.1\|3040049_3040334_-	hypothetical protein	A0A288WGA9	Bacillus_phage	4.3e-07	40.8
WP_073539486.1\|3040829_3041159_-	hypothetical protein	A0A0K2CZA4	Paenibacillus_phage	3.7e-18	45.3
WP_073539487.1\|3041155_3041536_-	HK97 gp10 family phage protein	H0USW9	Bacillus_phage	2.3e-16	33.3
WP_073539488.1\|3041528_3041855_-\|head	phage head closure protein	A6M954	Geobacillus_virus	8.7e-12	37.9
WP_073539489.1\|3042444_3042921_-	hypothetical protein	NA	NA	NA	NA
WP_073539490.1\|3043027_3043660_-	CatB-related O-acetyltransferase	A0A2R8FE91	Brazilian_cedratvirus	6.4e-27	41.2
WP_073539491.1\|3043891_3044749_-	AraC family transcriptional regulator	D0R0F8	Streptococcus_phage	1.4e-21	29.3
WP_073539492.1\|3044926_3045382_-	DNA gyrase inhibitor	A0A1P8CX48	Bacillus_phage	7.1e-28	43.0
WP_073539493.1\|3045557_3046016_-	hypothetical protein	NA	NA	NA	NA
WP_083585740.1\|3046196_3047489_-\|capsid	phage major capsid protein	NA	NA	NA	NA
WP_073539495.1\|3048276_3049536_-\|portal	phage portal protein	Q8HAD4	Salmonella_phage	1.3e-68	39.2
WP_073539496.1\|3049547_3051098_-\|terminase	terminase large subunit	A0A2K5B285	Erysipelothrix_phage	3.3e-226	72.1
WP_073539497.1\|3051101_3051575_-\|terminase	phage terminase small subunit P27 family	Q6DMU4	Streptococcus_phage	9.9e-57	68.8
WP_073539498.1\|3051624_3052077_-	gamma-glutamylcyclotransferase	NA	NA	NA	NA
WP_073539499.1\|3052102_3052996_-	amidoligase	A0A2K9V489	Faecalibacterium_phage	1.1e-64	43.6
WP_073539500.1\|3053112_3054333_-	site-specific DNA-methyltransferase	Q6DMV0	Streptococcus_phage	6.6e-121	52.3
WP_073539501.1\|3054394_3054832_-	helix-turn-helix domain-containing protein	A0A1B0RXC6	Streptococcus_phage	2.4e-17	36.4
WP_073539502.1\|3055509_3056013_-	DUF3368 domain-containing protein	NA	NA	NA	NA
WP_083585741.1\|3056005_3056314_-	UPF0175 family protein	NA	NA	NA	NA
WP_156876060.1\|3056531_3056699_-	hypothetical protein	NA	NA	NA	NA
WP_073539503.1\|3056717_3056987_-	hypothetical protein	NA	NA	NA	NA
WP_073539504.1\|3057492_3057909_-	hypothetical protein	NA	NA	NA	NA
WP_073539505.1\|3057913_3058213_-	VRR-NUC domain-containing protein	I3VYX6	Thermoanaerobacterium_phage	7.4e-26	57.1
WP_073539506.1\|3058218_3058695_-	hypothetical protein	NA	NA	NA	NA
WP_156876138.1\|3058977_3061461_-	DUF927 domain-containing protein	I3VYX9	Thermoanaerobacterium_phage	6.8e-266	54.1
WP_073539508.1\|3061527_3062271_-	hypothetical protein	I3VYY1	Thermoanaerobacterium_phage	1.3e-47	43.5
WP_073541351.1\|3062395_3062794_-	hypothetical protein	I3VYY4	Thermoanaerobacterium_phage	7.6e-34	54.6
WP_073539509.1\|3063066_3064245_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_073539510.1\|3064476_3064830_-	helix-turn-helix transcriptional regulator	A0A1S5SFA6	Streptococcus_phage	3.2e-20	42.5
WP_073539511.1\|3064998_3065196_+	DNA-binding protein	NA	NA	NA	NA
WP_073539512.1\|3065185_3065800_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073539513.1\|3065956_3066874_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	4.6e-42	44.9
WP_073539514.1\|3066866_3067616_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_073539515.1\|3067615_3068446_+	undecaprenyl-diphosphate phosphatase	NA	NA	NA	NA
WP_156876061.1\|3068643_3069893_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	2.0e-11	30.3

DBSCAN-SWA_11

3077049 : 3118604

Erysipelothrix_phage(38.71%)

tail,head,protease,capsid,holin,portal,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073539521.1\|3077049_3078618_-	recombinase family protein	A0A2K5B2B4	Erysipelothrix_phage	3.2e-176	60.9
WP_073539522.1\|3078619_3079054_-	hypothetical protein	NA	NA	NA	NA
WP_073539523.1\|3079054_3080620_-	recombinase family protein	A0A2K5B2B2	Erysipelothrix_phage	5.8e-146	51.0
WP_083585742.1\|3080680_3080914_-	hypothetical protein	NA	NA	NA	NA
WP_073539525.1\|3080980_3082972_-	DNA polymerase	A0A2K5B2B0	Erysipelothrix_phage	4.6e-265	68.2
WP_073539526.1\|3083040_3083604_-	DUF2815 family protein	Q6DMW3	Streptococcus_phage	1.5e-72	71.9
WP_073539527.1\|3083617_3084739_-	DUF2800 domain-containing protein	A0A1X9I6D8	Streptococcus_phage	4.2e-130	60.1
WP_073539528.1\|3084740_3085031_-	DNA ligase	A0A2K5B2A7	Erysipelothrix_phage	6.3e-06	32.4
WP_073539529.1\|3085023_3085224_-	hypothetical protein	A0A2I4R673	Erysipelothrix_phage	1.5e-14	59.7
WP_073539530.1\|3085355_3086027_-	N-acetylmuramoyl-L-alanine amidase	A0A0N9SGH1	Paenibacillus_phage	5.4e-24	37.7
WP_073539531.1\|3086026_3086425_-\|holin	phage holin family protein	A0A2K5B2A2	Erysipelothrix_phage	1.6e-39	59.7
WP_073539532.1\|3086450_3087815_-	hypothetical protein	Q0H227	Geobacillus_phage	4.3e-12	25.6
WP_073539533.1\|3088068_3089100_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073539534.1\|3089386_3089674_-	hypothetical protein	NA	NA	NA	NA
WP_073539535.1\|3089912_3090677_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_073539536.1\|3090830_3091802_-	phosphotransferase	NA	NA	NA	NA
WP_073541353.1\|3091917_3092541_-	lactate utilization protein	NA	NA	NA	NA
WP_073539537.1\|3092790_3093918_-	hypothetical protein	NA	NA	NA	NA
WP_073539538.1\|3093919_3095776_-	hypothetical protein	A0A0A7RUI9	Clostridium_phage	2.8e-54	40.3
WP_073539539.1\|3095775_3096483_-\|tail	phage tail protein	A0A1L2BYA2	Clostridium_phage	8.5e-20	28.3
WP_073539540.1\|3096484_3098926_-\|tail	phage tail tape measure protein	A8ATH6	Listeria_phage	9.3e-50	45.5
WP_073539541.1\|3099128_3099413_-	hypothetical protein	A0A288WGA9	Bacillus_phage	1.2e-06	37.8
WP_073539542.1\|3099437_3100004_-	hypothetical protein	A0A2H4J8F3	uncultured_Caudovirales_phage	6.5e-31	44.0
WP_073539543.1\|3100009_3100339_-	hypothetical protein	A0A0K2CZA4	Paenibacillus_phage	6.9e-17	47.5
WP_073539544.1\|3100335_3100716_-	HK97 gp10 family phage protein	H0USW9	Bacillus_phage	4.7e-17	34.8
WP_073539545.1\|3100708_3101035_-\|head	phage head closure protein	A0A0A7RUH8	Clostridium_phage	2.3e-20	45.9
WP_073539546.1\|3101031_3101601_-	hypothetical protein	NA	NA	NA	NA
WP_073539547.1\|3101624_3102101_-	hypothetical protein	NA	NA	NA	NA
WP_073539548.1\|3102260_3103070_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_083585743.1\|3103249_3104542_-\|capsid	phage major capsid protein	NA	NA	NA	NA
WP_156876140.1\|3104575_3105250_-\|protease	Clp protease ClpP	A6M950	Geobacillus_virus	4.1e-56	54.5
WP_073539551.1\|3105330_3106590_-\|portal	phage portal protein	Q8W629	Enterobacteria_phage	1.2e-69	41.2
WP_083585834.1\|3106601_3108164_-\|terminase	terminase large subunit	A0A2K5B285	Erysipelothrix_phage	8.5e-206	65.1
WP_073539553.1\|3108217_3108724_-	hypothetical protein	A0A220GJG3	Streptococcus_phage	3.7e-25	39.0
WP_073539554.1\|3108726_3109203_-\|terminase	phage terminase small subunit P27 family	Q6DMU4	Streptococcus_phage	6.4e-56	68.6
WP_073539555.1\|3109262_3109478_-	gamma-glutamylcyclotransferase	NA	NA	NA	NA
WP_073539556.1\|3109527_3110223_-	hypothetical protein	NA	NA	NA	NA
WP_073539557.1\|3110336_3110648_-	hypothetical protein	NA	NA	NA	NA
WP_073539558.1\|3110716_3111949_-	DNA modification methylase	A0A2I4R670	Erysipelothrix_phage	1.9e-144	58.6
WP_073539559.1\|3112209_3112602_-	HNH endonuclease	M1PLL8	Streptococcus_phage	1.3e-22	45.1
WP_073539560.1\|3112715_3113144_-	DUF1492 domain-containing protein	A0A2K5B275	Erysipelothrix_phage	7.9e-13	33.8
WP_073539561.1\|3113143_3113368_-	hypothetical protein	NA	NA	NA	NA
WP_073539562.1\|3113360_3114722_-	DEAD/DEAH box helicase	A0A2K5B273	Erysipelothrix_phage	1.5e-166	75.3
WP_073539563.1\|3114702_3114984_-	VRR-NUC domain-containing protein	A0A2K5B272	Erysipelothrix_phage	7.9e-30	72.2
WP_073539564.1\|3115127_3117377_-	DNA primase	A0A1B0RXC5	Streptococcus_phage	9.4e-206	47.8
WP_073539565.1\|3117373_3117802_-	DUF4406 domain-containing protein	A0A2K5B270	Erysipelothrix_phage	1.2e-37	54.2
WP_073539566.1\|3117806_3118604_-	phage antirepressor KilAC domain-containing protein	A0A1Q1PVU2	Staphylococcus_phage	7.2e-68	50.7

DBSCAN-SWA_12

3143481 : 3149293

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073539590.1\|3143481_3144981_-	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	5.9e-63	43.6
WP_073539591.1\|3145000_3145615_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.3e-24	38.0
WP_073539592.1\|3145602_3146598_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SCX2	Cyanophage	3.8e-66	44.6
WP_073539593.1\|3146611_3148063_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.1e-58	34.6
WP_012103030.1\|3148103_3148811_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3F9V5	Synechococcus_phage	2.0e-45	45.4
WP_073539594.1\|3148813_3149293_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.3e-29	48.1

DBSCAN-SWA_13

3318538 : 3356668

Leptospira_phage(28.57%)

transposase,integrase

attL 3336463:3336480|attR 3359935:3359952

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073539745.1\|3318538_3318622_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_073539746.1\|3319442_3319796_+	hypothetical protein	NA	NA	NA	NA
WP_073539747.1\|3320076_3321000_+	LD-carboxypeptidase	NA	NA	NA	NA
WP_073539748.1\|3321953_3322904_+	hypothetical protein	NA	NA	NA	NA
WP_156876004.1\|3322964_3324213_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	2.0e-11	30.3
WP_073539749.1\|3324552_3324750_-	cold-shock protein	A0A1X9IGI9	Lactococcus_phage	2.2e-18	70.0
WP_073539750.1\|3325395_3325674_-	hypothetical protein	NA	NA	NA	NA
WP_073539751.1\|3326153_3326582_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_073541359.1\|3326656_3328522_+	DHA2 family efflux MFS transporter permease subunit	NA	NA	NA	NA
WP_156876004.1\|3328624_3329874_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	2.0e-11	30.3
WP_073539752.1\|3330026_3330569_+	superoxide dismutase family protein	A0A1V0SDD3	Indivirus	2.8e-07	35.3
WP_156876141.1\|3330655_3330787_-	DUF3189 family protein	NA	NA	NA	NA
WP_156876067.1\|3331191_3331362_+	hypothetical protein	NA	NA	NA	NA
WP_073539754.1\|3332227_3332881_+	metal ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	2.2e-14	31.2
WP_073539755.1\|3332907_3333702_+	metal ABC transporter permease	NA	NA	NA	NA
WP_073539756.1\|3333770_3334064_-	DUF2325 domain-containing protein	NA	NA	NA	NA
WP_073539757.1\|3334297_3335368_-	nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	NA	NA	NA	NA
WP_073539758.1\|3335443_3336070_-	NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_073539759.1\|3336117_3337095_-	cobalamin biosynthesis protein	NA	NA	NA	NA
3336463:3336480	attL	NA	NA	NA	NA
WP_073539760.1\|3337133_3337688_-	NUDIX hydrolase	NA	NA	NA	NA
WP_073539761.1\|3337687_3339136_-	PLP-dependent aminotransferase family protein	NA	NA	NA	NA
WP_073539762.1\|3339301_3340117_-	MetQ/NlpA family ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_073539763.1\|3340491_3341385_+	D-alanine--D-alanine ligase	NA	NA	NA	NA
WP_073539764.1\|3341430_3343926_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_073539765.1\|3344072_3345101_-	3-deoxy-7-phosphoheptulonate synthase	S4W5F1	Pandoravirus	2.3e-42	32.9
WP_073539766.1\|3345193_3345805_-	thiamine phosphate synthase	NA	NA	NA	NA
WP_073539767.1\|3345795_3346605_-	hydroxyethylthiazole kinase	NA	NA	NA	NA
WP_073539768.1\|3346671_3347472_-	bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase	NA	NA	NA	NA
WP_073539769.1\|3347943_3348942_+	M28 family peptidase	NA	NA	NA	NA
WP_073539770.1\|3350467_3350671_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_073539771.1\|3350740_3352411_-	DEAD/DEAH box helicase	NA	NA	NA	NA
WP_073539772.1\|3352570_3353389_+	hypothetical protein	NA	NA	NA	NA
WP_073538466.1\|3354095_3355322_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	7.0e-54	53.2
WP_083585747.1\|3355520_3356144_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_073539773.1\|3356482_3356668_-\|transposase	transposase	NA	NA	NA	NA
3359935:3359952	attR	NA	NA	NA	NA

DBSCAN-SWA_14

3460137 : 3465872

Bacillus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073539859.1\|3460137_3460815_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.1e-36	40.4
WP_073539860.1\|3460911_3461940_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	5.5e-20	25.1
WP_073539861.1\|3461929_3462619_-	response regulator transcription factor	W8CYM9	Bacillus_phage	4.1e-27	33.2
WP_073539862.1\|3462641_3464054_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	7.3e-23	26.3
WP_073539863.1\|3464080_3464800_-	response regulator transcription factor	W8CYM9	Bacillus_phage	2.0e-37	34.6
WP_073539864.1\|3464960_3465872_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	4.4e-45	45.9

DBSCAN-SWA_15

3670356 : 3738684

uncultured_Caudovirales_phage(43.33%)

tail,capsid,holin,terminase,tRNA,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073540029.1\|3670356_3672735_-\|tRNA	phenylalanine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_073540030.1\|3672798_3673818_-\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2K9L3A8	Tupanvirus	1.4e-31	34.9
WP_073540031.1\|3674179_3674980_-	RNA methyltransferase	NA	NA	NA	NA
WP_073540032.1\|3675116_3675476_-	50S ribosomal protein L20	NA	NA	NA	NA
WP_012103540.1\|3675505_3675703_-	50S ribosomal protein L35	NA	NA	NA	NA
WP_073540033.1\|3675958_3677872_-\|tRNA	threonine--tRNA ligase	A0A2K9L6B6	Tupanvirus	3.3e-143	40.3
WP_073540034.1\|3678269_3679169_-	putative sporulation protein YtxC	NA	NA	NA	NA
WP_073540035.1\|3679893_3682134_-	PAS domain S-box protein	NA	NA	NA	NA
WP_073540036.1\|3682612_3683773_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_073540037.1\|3683944_3684697_-	4-hydroxy-tetrahydrodipicolinate reductase	NA	NA	NA	NA
WP_073540038.1\|3684842_3685724_-	4-hydroxy-tetrahydrodipicolinate synthase	NA	NA	NA	NA
WP_073540039.1\|3685780_3686767_-	aspartate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_073540040.1\|3687070_3687340_+	alpha/beta-type small acid-soluble spore protein	NA	NA	NA	NA
WP_073540041.1\|3687476_3688220_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_073541395.1\|3688312_3689200_+	Hsp33 family molecular chaperone HslO	NA	NA	NA	NA
WP_073540042.1\|3689317_3690034_+	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase	NA	NA	NA	NA
WP_073540043.1\|3690087_3690831_-	single-stranded DNA-binding protein	A0A2H4J8K3	uncultured_Caudovirales_phage	2.6e-51	51.4
WP_073540044.1\|3690928_3691417_-	hypothetical protein	NA	NA	NA	NA
WP_156876076.1\|3691623_3692406_-	polysaccharide deacetylase family sporulation protein PdaB	NA	NA	NA	NA
WP_073540046.1\|3692546_3693071_+	DUF4364 family protein	NA	NA	NA	NA
WP_073540047.1\|3693076_3693964_-	YncE family protein	NA	NA	NA	NA
WP_073540048.1\|3694134_3694383_+	TIGR03905 family TSCPD domain-containing protein	NA	NA	NA	NA
WP_073540049.1\|3694489_3695824_-	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_073541397.1\|3695842_3698491_-\|tRNA	valine--tRNA ligase	A0A1V0SK04	Klosneuvirus	2.9e-182	44.5
WP_073540050.1\|3698816_3699599_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_156876077.1\|3699645_3699789_-	hypothetical protein	NA	NA	NA	NA
WP_073540051.1\|3700093_3700375_+	helix-turn-helix transcriptional regulator	A0A0A7RUG5	Clostridium_phage	9.5e-07	43.2
WP_073540052.1\|3700501_3700858_+	helix-turn-helix transcriptional regulator	A0A0A8WF84	Clostridium_phage	1.0e-05	35.7
WP_073540053.1\|3701068_3701527_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_083585764.1\|3701922_3703095_+	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_073540054.1\|3703516_3704611_-	hypothetical protein	A0A1W6JNN3	Staphylococcus_phage	1.5e-15	33.5
WP_073540055.1\|3704610_3706539_-	N-6 DNA methylase	A0A1W6JNK1	Staphylococcus_phage	1.5e-164	47.4
WP_073540056.1\|3706525_3706888_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_073540057.1\|3707517_3707925_+	hypothetical protein	NA	NA	NA	NA
WP_156876078.1\|3708656_3709043_-	hypothetical protein	NA	NA	NA	NA
WP_073540059.1\|3709129_3709369_-	hypothetical protein	NA	NA	NA	NA
WP_083585802.1\|3710340_3710652_-\|holin	phage holin family protein	A0A0E3Y658	Fusobacterium_phage	2.0e-18	53.0
WP_073537108.1\|3710848_3711073_-	hypothetical protein	NA	NA	NA	NA
WP_073541401.1\|3711150_3711264_-	XkdX family protein	NA	NA	NA	NA
WP_073540060.1\|3711301_3711652_-	hypothetical protein	NA	NA	NA	NA
WP_073540061.1\|3713114_3713735_-	YmfQ family protein	A0A0A7RTU9	Clostridium_phage	1.8e-74	61.7
WP_073537105.1\|3716113_3717238_-\|plate	baseplate J/gp47 family protein	A0A2H4J7K8	uncultured_Caudovirales_phage	1.5e-71	43.3
WP_073537104.1\|3717242_3717701_-	DUF2634 domain-containing protein	A0A2H4J4Q8	uncultured_Caudovirales_phage	1.3e-40	53.9
WP_073540062.1\|3717701_3718031_-	hypothetical protein	A0A0A8WFG6	Clostridium_phage	1.0e-20	48.1
WP_073540063.1\|3718005_3718989_-	XkdQ	A0A2H4J063	uncultured_Caudovirales_phage	1.1e-97	56.1
WP_073540064.1\|3719000_3719759_-	hypothetical protein	A0A2H4J045	uncultured_Caudovirales_phage	2.4e-65	54.8
WP_073540065.1\|3719891_3720086_-	hypothetical protein	NA	NA	NA	NA
WP_073540066.1\|3720090_3723915_-\|tail	phage tail tape measure protein	A0A2H4J055	uncultured_Caudovirales_phage	5.3e-108	41.5
WP_073540067.1\|3724091_3724529_-	hypothetical protein	A0A2H4J883	uncultured_Caudovirales_phage	3.4e-35	56.4
WP_156876079.1\|3724647_3725457_-	hypothetical protein	O64371	Lactobacillus_phage	1.9e-28	59.8
WP_073540068.1\|3725533_3725944_-\|tail	phage tail tube protein	A0A2H4J032	uncultured_Caudovirales_phage	1.6e-47	66.4
WP_073540069.1\|3725954_3727382_-\|tail	phage tail sheath protein	A0A2H4J1N7	uncultured_Caudovirales_phage	4.5e-153	57.5
WP_073540070.1\|3727383_3727695_-	hypothetical protein	A0A0A8WEX5	Clostridium_phage	8.6e-09	48.4
WP_073540071.1\|3727721_3728537_-	hypothetical protein	A0A2H4J4Q0	uncultured_Caudovirales_phage	1.2e-94	62.8
WP_073540072.1\|3728521_3728764_-	hypothetical protein	NA	NA	NA	NA
WP_073540073.1\|3728784_3729210_-	hypothetical protein	NA	NA	NA	NA
WP_073540074.1\|3729223_3729616_-	hypothetical protein	A0A2H4J057	uncultured_Caudovirales_phage	6.3e-25	51.5
WP_073540075.1\|3729615_3729936_-	hypothetical protein	A0A2H4J040	uncultured_Caudovirales_phage	4.1e-22	52.5
WP_073540076.1\|3729938_3730151_-	hypothetical protein	NA	NA	NA	NA
WP_073540077.1\|3730207_3731266_-\|capsid	phage capsid protein	A0A0A7RU11	Clostridium_phage	3.9e-77	45.7
WP_073540078.1\|3731278_3731665_-	hypothetical protein	D9ZND5	Clostridium_phage	3.8e-06	34.9
WP_073540079.1\|3731688_3732303_-	hypothetical protein	A0A0A7RW68	Clostridium_phage	8.7e-21	35.5
WP_073540080.1\|3732352_3732532_-	hypothetical protein	NA	NA	NA	NA
WP_073540081.1\|3732726_3733143_-	hypothetical protein	D9ZNC9	Clostridium_phage	2.4e-06	32.0
WP_073540082.1\|3733363_3735082_-	exonuclease SbcC	A0A2H4J048	uncultured_Caudovirales_phage	6.6e-135	46.5
WP_073540083.1\|3737916_3738684_-\|terminase	terminase	A0A0A8WFS6	Clostridium_phage	2.2e-37	48.7

DBSCAN-SWA_16

3746673 : 3797145

Clostridium_phage(66.67%)

tail,transposase,protease,portal,terminase,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073540095.1\|3746673_3747543_-	ATP-binding protein	A0A2K9V3L7	Faecalibacterium_phage	1.4e-29	34.9
WP_073540096.1\|3747472_3748291_-	hypothetical protein	A0A0A7RWV8	Clostridium_phage	2.3e-37	63.1
WP_073540097.1\|3749984_3751973_-	AAA family ATPase	A0A1L2K2K3	Aeribacillus_phage	1.5e-85	32.1
WP_156875979.1\|3751983_3752253_-	hypothetical protein	A0A2H4JG91	uncultured_Caudovirales_phage	1.6e-16	47.7
WP_073537052.1\|3752345_3752615_-	hypothetical protein	NA	NA	NA	NA
WP_156875978.1\|3752618_3752768_-	hypothetical protein	NA	NA	NA	NA
WP_156875977.1\|3752764_3752935_-	hypothetical protein	NA	NA	NA	NA
WP_156876083.1\|3752949_3753099_-	hypothetical protein	NA	NA	NA	NA
WP_073540098.1\|3753114_3753294_-	hypothetical protein	A0A0A7RTR9	Clostridium_phage	2.5e-05	44.6
WP_073540099.1\|3753290_3753818_-	hypothetical protein	A0A2H4J8I5	uncultured_Caudovirales_phage	4.7e-15	35.3
WP_156876084.1\|3753845_3754055_-	hypothetical protein	NA	NA	NA	NA
WP_156876085.1\|3754055_3754286_-	hypothetical protein	NA	NA	NA	NA
WP_073540100.1\|3754269_3754500_-	hypothetical protein	NA	NA	NA	NA
WP_073540101.1\|3754477_3754678_-	hypothetical protein	NA	NA	NA	NA
WP_073540102.1\|3754856_3755372_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073540103.1\|3755485_3755716_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073540104.1\|3755881_3756187_+	helix-turn-helix transcriptional regulator	A0A0U4B088	Bacillus_phage	1.1e-05	25.2
WP_073540105.1\|3756209_3756488_+	hypothetical protein	NA	NA	NA	NA
WP_073540106.1\|3756505_3756772_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073540107.1\|3756932_3757358_+	helix-turn-helix transcriptional regulator	A0A0P0IZG9	Lactobacillus_phage	1.5e-11	49.3
WP_073540108.1\|3757366_3757822_+	ImmA/IrrE family metallo-endopeptidase	A8ATJ8	Listeria_phage	5.1e-10	29.4
WP_073540109.1\|3757828_3758899_+	endonuclease	A0A1S5SAB0	Streptococcus_phage	4.8e-75	41.5
WP_073540110.1\|3758994_3759795_-\|protease	YhfC family intramembrane metalloprotease	NA	NA	NA	NA
WP_156876086.1\|3759875_3760838_-	nuclease (SNase)	A0A1L2JY19	Aeribacillus_phage	1.6e-37	55.2
WP_073540112.1\|3761132_3761276_+	cyclic lactone autoinducer peptide	NA	NA	NA	NA
WP_073540113.1\|3761382_3762699_+	GHKL domain-containing protein	NA	NA	NA	NA
WP_073540114.1\|3762847_3763027_+	hypothetical protein	NA	NA	NA	NA
WP_156876087.1\|3765948_3766125_-	hypothetical protein	NA	NA	NA	NA
WP_073540115.1\|3766151_3767216_-	hypothetical protein	NA	NA	NA	NA
WP_073540116.1\|3767610_3767877_+	hypothetical protein	NA	NA	NA	NA
WP_073540117.1\|3768062_3768764_+	YjgB family protein	NA	NA	NA	NA
WP_073540118.1\|3768884_3769319_-	hypothetical protein	Q331X2	Clostridium_botulinum_C_phage	2.3e-12	39.5
WP_073540119.1\|3769368_3770190_-	N-acetylmuramoyl-L-alanine amidase	A0A1L6BY22	Clostridium_phage	2.4e-26	43.1
WP_073540120.1\|3770202_3770457_-	hypothetical protein	A0A0A7RTX0	Clostridium_phage	1.5e-06	42.5
WP_073540121.1\|3770544_3771372_-	hypothetical protein	NA	NA	NA	NA
WP_156876088.1\|3771439_3771613_-	hypothetical protein	NA	NA	NA	NA
WP_073541408.1\|3771947_3772061_-	XkdX family protein	NA	NA	NA	NA
WP_073540122.1\|3772086_3772449_-	hypothetical protein	NA	NA	NA	NA
WP_073540124.1\|3775900_3776446_-	DUF2313 domain-containing protein	NA	NA	NA	NA
WP_073540125.1\|3776438_3777524_-\|plate	baseplate J/gp47 family protein	A0A0A7RUN3	Clostridium_phage	3.0e-40	32.2
WP_073540126.1\|3777516_3777975_-	DUF2634 domain-containing protein	A0A0A7RUS1	Clostridium_phage	1.8e-23	40.5
WP_073540127.1\|3777953_3778325_-	DUF2577 domain-containing protein	NA	NA	NA	NA
WP_156876089.1\|3778321_3779332_-\|terminase	terminase	A0A0A7RWY4	Clostridium_phage	2.9e-58	39.1
WP_156876144.1\|3779328_3779733_-	hypothetical protein	A0A0A8WJR4	Clostridium_phage	1.2e-23	45.4
WP_156876145.1\|3779758_3783004_-	transglycosylase SLT domain-containing protein	D9ZNE6	Clostridium_phage	1.5e-34	46.6
WP_073540130.1\|3783187_3783397_-	hypothetical protein	NA	NA	NA	NA
WP_156876090.1\|3783492_3783669_-	hypothetical protein	NA	NA	NA	NA
WP_073540131.1\|3783674_3784049_-	hypothetical protein	NA	NA	NA	NA
WP_073540132.1\|3784145_3784607_-\|tail	phage tail tube protein	A0A0A7RVT1	Clostridium_phage	6.5e-29	47.2
WP_073540133.1\|3784619_3785705_-\|tail	phage tail sheath protein	A0A0A7S0D2	Clostridium_phage	2.1e-70	42.7
WP_073540134.1\|3785712_3786153_-	hypothetical protein	J9QE32	Clostridium_phage	4.0e-12	35.9
WP_073540135.1\|3786149_3786602_-	HK97 gp10 family phage protein	A0A0A7RTT0	Clostridium_phage	3.9e-18	42.5
WP_073540136.1\|3786601_3786952_-	hypothetical protein	A0A090EUC2	Clostridium_phage	1.7e-13	40.2
WP_073540137.1\|3786948_3787275_-	hypothetical protein	NA	NA	NA	NA
WP_073540138.1\|3787286_3787532_-	hypothetical protein	NA	NA	NA	NA
WP_073540139.1\|3787542_3788475_-	hypothetical protein	A0A090D825	Clostridium_phage	3.4e-117	65.7
WP_073540140.1\|3788501_3789119_-	hypothetical protein	A0A0A8WET0	Clostridium_phage	1.4e-05	26.5
WP_073541410.1\|3789226_3789553_-	helix-turn-helix transcriptional regulator	Q20DG0	Lactobacillus_phage	1.9e-06	44.1
WP_073540141.1\|3789578_3789926_-	hypothetical protein	NA	NA	NA	NA
WP_073540142.1\|3789990_3790191_-	hypothetical protein	NA	NA	NA	NA
WP_073540143.1\|3790187_3791750_-	hypothetical protein	A0A0A8WJ84	Clostridium_phage	2.8e-100	40.4
WP_083585768.1\|3791742_3793116_-\|portal	phage portal protein	A0A090DBP3	Clostridium_phage	2.9e-157	64.1
WP_073541414.1\|3793130_3794534_-\|terminase	phage terminase large subunit	A0A090EUA8	Clostridium_phage	8.7e-210	74.4
WP_073540144.1\|3794526_3795048_-\|transposase	transposase	A0A0A7RTH0	Clostridium_phage	1.6e-63	80.0
WP_073540084.1\|3795197_3795533_+	hypothetical protein	NA	NA	NA	NA
WP_073540085.1\|3795801_3795990_+	hypothetical protein	NA	NA	NA	NA
WP_073541405.1\|3796110_3796467_-	helix-turn-helix domain containing protein	M9Q1J7	Clostridium_phage	6.6e-21	42.3
WP_073540086.1\|3796677_3797145_-	transcriptional regulator	A0A0A7RVS1	Clostridium_phage	5.6e-28	41.6

DBSCAN-SWA_17

3809056 : 3818868

Clostridium_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073540150.1\|3809056_3809236_-	hypothetical protein	A0A0A7RTR9	Clostridium_phage	7.3e-05	44.6
WP_073540151.1\|3809252_3810014_-	hypothetical protein	NA	NA	NA	NA
WP_073540152.1\|3810038_3810248_-	hypothetical protein	NA	NA	NA	NA
WP_073540153.1\|3810265_3810481_-	hypothetical protein	NA	NA	NA	NA
WP_073540154.1\|3810483_3810888_-	hypothetical protein	NA	NA	NA	NA
WP_073540155.1\|3810894_3811101_-	hypothetical protein	NA	NA	NA	NA
WP_073540156.1\|3811078_3811273_-	hypothetical protein	NA	NA	NA	NA
WP_073540157.1\|3811273_3812062_-	ORF6N domain-containing protein	A0A0A7RUE5	Clostridium_phage	1.9e-68	53.5
WP_073540158.1\|3812087_3812582_-	helix-turn-helix transcriptional regulator	A0A2K9V3J3	Faecalibacterium_phage	5.5e-26	42.4
WP_148204860.1\|3812767_3812950_-	hypothetical protein	NA	NA	NA	NA
WP_083585841.1\|3812991_3813204_-	helix-turn-helix transcriptional regulator	A0A0K2CNP2	Brevibacillus_phage	2.3e-05	44.4
WP_073540160.1\|3813356_3813596_+	helix-turn-helix transcriptional regulator	A0A0K2CNE2	Brevibacillus_phage	1.6e-15	55.3
WP_073540162.1\|3813970_3814216_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073540163.1\|3814379_3814790_+	helix-turn-helix transcriptional regulator	A8ATJ9	Listeria_phage	1.1e-16	39.5
WP_073540164.1\|3814913_3815057_+	cyclic lactone autoinducer peptide	NA	NA	NA	NA
WP_083585842.1\|3815139_3815295_+	Spo0E family sporulation regulatory protein-aspartic acid phosphatase	NA	NA	NA	NA
WP_073540165.1\|3815419_3816733_+	GHKL domain-containing protein	NA	NA	NA	NA
WP_073540166.1\|3816881_3817061_+	hypothetical protein	NA	NA	NA	NA
WP_073540167.1\|3817227_3818868_+	recombinase family protein	A0A1L2BY67	Clostridium_phage	1.2e-104	42.3

DBSCAN-SWA_18

3921525 : 3956996

uncultured_Caudovirales_phage(18.18%)

transposase,integrase

attL 3926816:3926834|attR 3939955:3939973

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073538466.1\|3921525_3922752_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	7.0e-54	53.2
WP_083585645.1\|3924598_3925192_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_073540258.1\|3925739_3926420_+	DUF998 domain-containing protein	NA	NA	NA	NA
WP_073540259.1\|3926608_3926794_+	hypothetical protein	NA	NA	NA	NA
3926816:3926834	attL	NA	NA	NA	NA
WP_156876097.1\|3927183_3927525_+	PadR family transcriptional regulator	NA	NA	NA	NA
WP_073540260.1\|3927514_3928822_+	FtsW/RodA/SpoVE family cell cycle protein	NA	NA	NA	NA
WP_073540261.1\|3928909_3929929_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_073540262.1\|3931065_3931863_-	polysaccharide deacetylase	NA	NA	NA	NA
WP_073540263.1\|3932287_3933490_+	Na+/H+ antiporter NhaA	A0A2H4J5W3	uncultured_Caudovirales_phage	8.9e-62	40.1
WP_083585772.1\|3933638_3934178_-	arsenate reductase ArsC	A0A2H4J8A6	uncultured_Caudovirales_phage	2.1e-18	32.9
WP_156876098.1\|3935094_3935295_+	hypothetical protein	NA	NA	NA	NA
WP_083585773.1\|3935391_3936189_+	hypothetical protein	A0A0U4J920	Pseudomonas_phage	1.8e-18	36.3
WP_073540265.1\|3936227_3937241_-\|integrase	site-specific integrase	A0A0K2CP59	Brevibacillus_phage	3.8e-21	27.3
WP_073539205.1\|3937227_3938214_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_073539206.1\|3938206_3939442_-\|integrase	tyrosine-type recombinase/integrase	A0A1B1P7Y2	Bacillus_phage	6.0e-05	26.6
WP_073540266.1\|3939500_3939722_+	HNH endonuclease	NA	NA	NA	NA
WP_073540267.1\|3940008_3940542_-	permease	NA	NA	NA	NA
3939955:3939973	attR	NA	NA	NA	NA
WP_073540268.1\|3940538_3941024_-	permease	NA	NA	NA	NA
WP_012102109.1\|3941117_3941345_-	thioredoxin family protein	NA	NA	NA	NA
WP_073540269.1\|3941397_3942414_-	permease	NA	NA	NA	NA
WP_073540270.1\|3942448_3942811_-	metalloregulator ArsR/SmtB family transcription factor	NA	NA	NA	NA
WP_156876099.1\|3943030_3943201_+	hypothetical protein	NA	NA	NA	NA
WP_073540271.1\|3943206_3946173_-\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	3.3e-214	40.3
WP_073540272.1\|3946959_3947922_+	YafY family transcriptional regulator	A0A1B0RXM1	Streptococcus_phage	5.5e-14	29.2
WP_073540273.1\|3947997_3948630_+	glutamine amidotransferase	NA	NA	NA	NA
WP_073540274.1\|3949353_3950199_-	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	9.5e-10	25.1
WP_156876100.1\|3950191_3950548_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_073540275.1\|3951479_3951860_-	hypothetical protein	NA	NA	NA	NA
WP_073540276.1\|3952505_3952886_-	hypothetical protein	NA	NA	NA	NA
WP_073540278.1\|3953237_3953615_-	hypothetical protein	H9YS02	environmental_Halophage	2.5e-10	37.9
WP_083585774.1\|3953584_3954253_+	M28 family peptidase	NA	NA	NA	NA
WP_156876101.1\|3954354_3954495_-	hypothetical protein	NA	NA	NA	NA
WP_073540279.1\|3954506_3954695_-	hypothetical protein	NA	NA	NA	NA
WP_073541430.1\|3954701_3955085_-	hypothetical protein	NA	NA	NA	NA
WP_073540280.1\|3955178_3955565_-	Bro-N domain-containing protein	W5R8S2	Staphylococcus_phage	1.9e-29	63.4
WP_073538976.1\|3955817_3956996_+\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_19

4062737 : 4090493

Staphylococcus_phage(40.0%)

protease,transposase,integrase

attL 4056879:4056894|attR 4073253:4073268

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
4056879:4056894	attL	NA	NA	NA	NA
WP_073537162.1\|4062737_4064165_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A1X9I6E7	Streptococcus_phage	9.1e-05	29.8
WP_073540362.1\|4064659_4065103_+	hypothetical protein	NA	NA	NA	NA
WP_156876108.1\|4065095_4065242_-	hypothetical protein	NA	NA	NA	NA
WP_073540364.1\|4066321_4066648_+	hypothetical protein	NA	NA	NA	NA
WP_073540365.1\|4066641_4066992_+	IS66 family insertion sequence element accessory protein TnpB	S5VXZ8	Leptospira_phage	1.1e-17	46.7
WP_073540366.1\|4067077_4067533_+	hypothetical protein	NA	NA	NA	NA
WP_083585780.1\|4067635_4067794_+\|transposase	transposase	NA	NA	NA	NA
WP_073540367.1\|4067810_4068080_+\|transposase	transposase	NA	NA	NA	NA
WP_083585781.1\|4067994_4068288_+\|transposase	transposase	NA	NA	NA	NA
WP_073540370.1\|4069020_4070205_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_073540371.1\|4070201_4070891_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.5e-32	34.9
WP_073540372.1\|4070865_4071930_-	HlyD family efflux transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_073540373.1\|4072483_4073185_-	hypothetical protein	NA	NA	NA	NA
WP_156876109.1\|4073181_4073868_-	hypothetical protein	NA	NA	NA	NA
4073253:4073268	attR	NA	NA	NA	NA
WP_083585782.1\|4073875_4074634_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	5.7e-22	29.9
WP_156876110.1\|4075650_4076262_-	hypothetical protein	NA	NA	NA	NA
WP_083585783.1\|4076278_4076905_-	hypothetical protein	NA	NA	NA	NA
WP_073540377.1\|4077030_4077603_+	accessory gene regulator B family protein	NA	NA	NA	NA
WP_083585784.1\|4077599_4077737_+	cyclic lactone autoinducer peptide	NA	NA	NA	NA
WP_083585785.1\|4077728_4079009_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_073540379.1\|4079026_4079761_-	response regulator transcription factor	NA	NA	NA	NA
WP_156876111.1\|4080912_4081071_-	hypothetical protein	NA	NA	NA	NA
WP_073537418.1\|4083675_4084929_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_073540383.1\|4085328_4085715_+	hypothetical protein	NA	NA	NA	NA
WP_073540384.1\|4085870_4086695_+	hypothetical protein	NA	NA	NA	NA
WP_073540385.1\|4086684_4087557_+	hypothetical protein	NA	NA	NA	NA
WP_073540386.1\|4087549_4088380_+	hypothetical protein	NA	NA	NA	NA
WP_073540387.1\|4088403_4089051_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	1.2e-33	40.1
WP_073540388.1\|4089962_4090493_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_20

4220736 : 4258931

Streptococcus_phage(28.57%)

tRNA,transposase,integrase

attL 4256919:4256937|attR 4260263:4260281

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073540597.1\|4220736_4223172_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	2.3e-213	47.6
WP_012103928.1\|4223201_4223993_-	GTP pyrophosphokinase family protein	NA	NA	NA	NA
WP_083585792.1\|4224052_4224913_+	DUF2225 domain-containing protein	NA	NA	NA	NA
WP_073540599.1\|4224993_4225680_-	serine/threonine protein phosphatase	NA	NA	NA	NA
WP_073540609.1\|4225684_4225951_-	flagellar biogenesis protein	NA	NA	NA	NA
WP_083585793.1\|4225995_4227666_-	hypothetical protein	NA	NA	NA	NA
WP_073540610.1\|4227798_4228425_-	ECF transporter S component	NA	NA	NA	NA
WP_073540612.1\|4228761_4230915_-	RNA-binding transcriptional accessory protein	NA	NA	NA	NA
WP_073540613.1\|4231494_4232679_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_073540615.1\|4232675_4233365_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	9.7e-29	33.5
WP_073540617.1\|4233339_4234401_-	HlyD family efflux transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_073537162.1\|4234577_4236005_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A1X9I6E7	Streptococcus_phage	9.1e-05	29.8
WP_073540619.1\|4236311_4236989_-	YIP1 family protein	NA	NA	NA	NA
WP_156876114.1\|4237132_4238243_-	peptide chain release factor 2	W8EDB3	Pseudomonas_phage	5.8e-07	44.8
WP_073540622.1\|4238263_4240768_-	preprotein translocase subunit SecA	NA	NA	NA	NA
WP_012103941.1\|4240931_4241459_-	ribosome-associated translation inhibitor RaiA	NA	NA	NA	NA
WP_073540624.1\|4241619_4242654_-	branched-chain amino acid aminotransferase	NA	NA	NA	NA
WP_012103943.1\|4242968_4243568_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_073540626.1\|4243931_4244927_+	acyltransferase family protein	NA	NA	NA	NA
WP_012103945.1\|4245093_4245288_-	hypothetical protein	NA	NA	NA	NA
WP_073540628.1\|4245452_4245650_-	alpha/beta-type small acid-soluble spore protein	NA	NA	NA	NA
WP_073540630.1\|4245897_4247019_+	UDP-galactopyranose mutase	E4ZFQ1	Streptococcus_phage	2.0e-148	65.6
WP_073540631.1\|4247096_4248113_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_073540633.1\|4248113_4248773_-	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_073540634.1\|4249196_4249427_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_083585794.1\|4249561_4249783_+	aspartyl-phosphate phosphatase Spo0E family protein	NA	NA	NA	NA
WP_156876115.1\|4250261_4251510_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	7.4e-11	27.4
WP_073540640.1\|4251522_4251795_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_073540642.1\|4252157_4252541_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_073540644.1\|4252722_4253013_+	hypothetical protein	NA	NA	NA	NA
WP_073540646.1\|4253174_4254167_-	hypothetical protein	NA	NA	NA	NA
WP_073540649.1\|4254301_4254748_-	hypothetical protein	NA	NA	NA	NA
WP_083585795.1\|4255729_4256848_-	group II intron reverse transcriptase/maturase	NA	NA	NA	NA
4256919:4256937	attL	NA	NA	NA	NA
WP_073540651.1\|4256944_4257958_-\|integrase	site-specific integrase	A0A0K2CP59	Brevibacillus_phage	9.9e-22	26.8
WP_073539205.1\|4257944_4258931_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
4260263:4260281	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP018336

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

9827 : 56089

Clostridium_phage(66.67%)

protease,capsid,terminase,tail,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_073541499.1\|9827_10628_+\|protease	YhfC family intramembrane metalloprotease	NA	NA	NA	NA
WP_073541501.1\|11889_12093_+	helix-turn-helix transcriptional regulator	S6BA02	Thermus_phage	8.0e-08	45.2
WP_156876149.1\|12568_13108_+	hypothetical protein	NA	NA	NA	NA
WP_073541505.1\|13112_13325_+	hypothetical protein	NA	NA	NA	NA
WP_012102339.1\|13325_13478_+	hypothetical protein	NA	NA	NA	NA
WP_073541507.1\|13484_13907_+	hypothetical protein	NA	NA	NA	NA
WP_073541509.1\|13931_14693_+	hypothetical protein	Q0SPI3	Clostridium_phage	1.8e-23	32.9
WP_156876150.1\|14903_15041_+	hypothetical protein	NA	NA	NA	NA
WP_156876151.1\|15289_15559_+	hypothetical protein	A0A2H4JG91	uncultured_Caudovirales_phage	6.7e-18	48.8
WP_073541515.1\|15569_17558_+	AAA family ATPase	A0A1L2K2K3	Aeribacillus_phage	2.7e-87	32.9
WP_073541517.1\|17578_18511_+	recombinase RecT	A0A1L2JY28	Aeribacillus_phage	9.3e-59	45.4
WP_083585846.1\|18510_19236_+	MBL fold metallo-hydrolase	A8ATK9	Listeria_phage	8.9e-65	50.9
WP_073541529.1\|19384_20269_+	hypothetical protein	A0A1L2JY26	Aeribacillus_phage	1.5e-05	30.6
WP_083585847.1\|20180_21008_+	MerR family transcriptional regulator	M9Q1J4	Clostridium_phage	1.4e-53	47.3
WP_073541532.1\|21014_21419_+	hypothetical protein	NA	NA	NA	NA
WP_073541534.1\|21566_21887_+	hypothetical protein	NA	NA	NA	NA
WP_073540094.1\|21970_22372_+	DUF1064 domain-containing protein	A8ASP7	Listeria_phage	1.1e-08	39.3
WP_073541536.1\|22375_22711_+	hypothetical protein	NA	NA	NA	NA
WP_156876152.1\|22731_23061_+	hypothetical protein	NA	NA	NA	NA
WP_073541538.1\|23088_23448_+	hypothetical protein	A0A143FJB8	Bacillus_phage	2.3e-34	56.9
WP_073541540.1\|23549_23966_+	hypothetical protein	NA	NA	NA	NA
WP_073541542.1\|24512_25031_+	hypothetical protein	A0A0A7RVX8	Clostridium_phage	1.8e-19	45.0
WP_073537069.1\|25144_26149_+	DUF3231 family protein	NA	NA	NA	NA
WP_073541544.1\|26622_27024_-	pilus assembly protein HicB	A0A0A7S1E5	Clostridium_phage	5.8e-50	71.2
WP_073541546.1\|27078_27261_-	type II toxin-antitoxin system HicA family toxin	I3NLB3	Bifidobacterium_phage	2.0e-10	51.8
WP_073541559.1\|28018_28786_+\|terminase	terminase	A0A0A8WFS6	Clostridium_phage	7.5e-38	46.3
WP_073541561.1\|28785_30129_+\|terminase	PBSX family phage terminase large subunit	A0A2P1JTW5	Anoxybacillus_phage	2.6e-155	68.3
WP_073541562.1\|30128_31571_+\|portal	phage portal protein	A0A0A7RW62	Clostridium_phage	3.5e-145	51.2
WP_073541564.1\|31580_32885_+	hypothetical protein	A0A0A7RU06	Clostridium_phage	6.4e-90	46.1
WP_073541566.1\|32896_33064_+	hypothetical protein	A0A1X9I5Q7	Streptococcus_phage	2.5e-07	46.3
WP_156876153.1\|33114_33384_+	hypothetical protein	NA	NA	NA	NA
WP_073541570.1\|33395_33623_+	hypothetical protein	NA	NA	NA	NA
WP_156876154.1\|33667_33835_+	hypothetical protein	NA	NA	NA	NA
WP_073541572.1\|33835_34474_+	hypothetical protein	A0A0A7RW68	Clostridium_phage	4.0e-21	34.9
WP_073541574.1\|34492_34843_+	hypothetical protein	A0A0A7RU46	Clostridium_phage	4.2e-20	50.0
WP_073541576.1\|34864_35902_+\|capsid	phage capsid protein	A0A0A7RU11	Clostridium_phage	9.5e-121	61.7
WP_073541578.1\|35953_36163_+	hypothetical protein	NA	NA	NA	NA
WP_073541580.1\|36176_36452_+	hypothetical protein	A0A0A7S0R4	Clostridium_phage	7.5e-25	59.0
WP_073541582.1\|36448_36820_+	hypothetical protein	NA	NA	NA	NA
WP_073541638.1\|36825_37263_+	hypothetical protein	A0A0A7RU51	Clostridium_phage	2.0e-19	41.5
WP_073541584.1\|37271_37703_+	hypothetical protein	A0A0A7RU17	Clostridium_phage	5.1e-28	40.7
WP_083585848.1\|37709_38612_+	hypothetical protein	A0A0A7RTZ9	Clostridium_phage	2.6e-58	44.1
WP_073541586.1\|38623_39085_+	hypothetical protein	NA	NA	NA	NA
WP_073541642.1\|39074_39254_+	hypothetical protein	A0A0A7RW80	Clostridium_phage	2.7e-07	49.1
WP_156876155.1\|41105_42014_+	hypothetical protein	A0A1W6JK50	Lactococcus_phage	1.3e-44	39.5
WP_083585849.1\|42232_43531_+\|tail	phage tail tape measure protein	A0A0A7RU22	Clostridium_phage	1.5e-35	34.8
WP_073541594.1\|43543_43981_+	hypothetical protein	NA	NA	NA	NA
WP_083585850.1\|43967_45083_+	hypothetical protein	A0A0A7RU03	Clostridium_phage	4.0e-40	31.6
WP_073541597.1\|45084_45429_+	hypothetical protein	A0A0A7S0S4	Clostridium_phage	3.4e-14	42.5
WP_073541599.1\|45441_46002_+	hypothetical protein	A0A0A7RW86	Clostridium_phage	1.2e-64	67.9
WP_073541601.1\|46004_47012_+	hypothetical protein	A0A0A7RU61	Clostridium_phage	1.7e-106	56.1
WP_073541603.1\|47023_48262_+	hypothetical protein	A0A0A7RU28	Clostridium_phage	8.6e-169	69.9
WP_073541605.1\|48273_50274_+	hypothetical protein	A0A0A7RU09	Clostridium_phage	1.4e-96	46.8
WP_073541607.1\|50257_50518_+	hypothetical protein	A0A0A7S0T0	Clostridium_phage	9.9e-27	65.5
WP_073541609.1\|50529_51525_+	hypothetical protein	A0A0A7RW91	Clostridium_phage	7.0e-129	66.3
WP_073541611.1\|51533_52619_+	signal peptidase II	A0A0A7RU66	Clostridium_phage	8.2e-107	52.9
WP_073541613.1\|52640_53717_+	hypothetical protein	H9YQW5	environmental_Halophage	2.6e-12	27.9
WP_073541615.1\|53848_54490_+	lactate utilization protein	NA	NA	NA	NA
WP_073541617.1\|54900_55155_+	hypothetical protein	NA	NA	NA	NA
WP_073541619.1\|55168_56089_+	glycosyl hydrolase	D9ZNF3	Clostridium_phage	1.3e-60	57.7

Anti-CRISPR protein detection

Acr_ID: NZ_CP018336.1|WP_073541534.1|21566_21887_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP018336.1|WP_073541534.1|21566_21887_+|hypothetical-protein

21566_21887_+

106 aa aa

9827-56089

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP018335_2	Unclear	2.2\|2066079\|36\|NZ_CP018335\|CRT,CRISPRCasFinder	2066079-2066114	36	42546-42511	1

1. spacer 2.2|2066079|36|NZ_CP018335|CRT,CRISPRCasFinder matches to NZ_CP018336 position: 42546-42511, mismatch: 1

ataactggtccgaaagctgctgctgcaagcccaaga	CRISPR spacer
ataactggtccgaaagctgctgctgcaagcccgaga	Protospacer
********************************.***

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP018335

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP018336

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information