CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP018439	Klebsiella pneumoniae strain Kp_Goe_822917 plasmid pKp_Goe_917-8, complete sequence	0 crisprs	NA	0	0
NZ_CP018438	Klebsiella pneumoniae strain Kp_Goe_822917 chromosome, complete genome	2 crisprs	csa3,cas3,DEDDh,RT,DinG,WYL	1	8
NZ_CP018440	Klebsiella pneumoniae strain Kp_Goe_822917 plasmid pKp_Goe_917-6, complete sequence	0 crisprs	NA	0	0
NZ_CP018442	Klebsiella pneumoniae strain Kp_Goe_822917 plasmid pKp_Goe_917-3, complete sequence	0 crisprs	NA	0	1
NZ_CP018446	Klebsiella pneumoniae strain Kp_Goe_822917 plasmid pKp_Goe_917-7, complete sequence	0 crisprs	NA	0	0
NZ_CP018443	Klebsiella pneumoniae strain Kp_Goe_822917 plasmid pKp_Goe_917-2, complete sequence	0 crisprs	NA	0	0
NZ_CP018441	Klebsiella pneumoniae strain Kp_Goe_822917 plasmid pKp_Goe_917-1, complete sequence	0 crisprs	csa3,cas3,RT	0	6
NZ_CP018444	Klebsiella pneumoniae strain Kp_Goe_822917 plasmid pKp_Goe_917-5, complete sequence	0 crisprs	NA	0	0
NZ_CP018445	Klebsiella pneumoniae strain Kp_Goe_822917 plasmid pKp_Goe_917-4, complete sequence	0 crisprs	NA	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

16849 : 26563

Escherichia_phage(28.57%)

integrase,transposase

attL 9744:9758|attR 21308:21322

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
9744:9758	attL	NA	NA	NA	NA
WP_000259031.1\|16849_17689_-	sulfonamide-resistant dihydropteroate synthase Sul1	A0A0B5J4J5	Pandoravirus	5.0e-11	27.2
WP_000679427.1\|17682_18030_-	quaternary ammonium compound efflux SMR transporter QacE delta 1	NA	NA	NA	NA
WP_001206356.1\|18193_18985_-	ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA2	NA	NA	NA	NA
WP_001336345.1\|18990_19281_-	DUF1010 domain-containing protein	NA	NA	NA	NA
WP_001083725.1\|19392_19890_-	trimethoprim-resistant dihydrofolate reductase DfrA12	A0A0A0PL85	Bacillus_phage	7.5e-23	40.9
WP_000845039.1\|20034_21048_+\|integrase	class 1 integron integrase IntI1	A0A1P8DJJ6	Virus_Rctr41k	1.0e-71	45.5
WP_001067858.1\|21360_22065_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.2e-138	99.6
21308:21322	attR	NA	NA	NA	NA
WP_001067858.1\|22151_22856_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.2e-138	99.6
WP_001749988.1\|23392_23962_+	recombinase family protein	E5FFF9	Burkholderia_phage	5.2e-36	43.2
WP_001749982.1\|25843_26563_-	replication initiation protein	I3WF20	Macacine_betaherpesvirus	8.6e-20	28.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP018438

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018438_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018438_1

3967262-3967357

Orphan

Consensus_repeat	Method
TGGCACTTTGTTGGCATTCTGTTGGCACAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018438_1

>merge|NZ_CP018438|1|3967262-3967357|CRISPRCasFinder
TGGCACTTTGTTGGCATTCTGTTGGCACAACCTCGCCGGTACGCAGCGTGGTTACTGGGTTTGCGTTGGCACTTTGTTGGCATTCTGTTGGCACAA

>NZ_CP018438|1|1|3967262-3967357|CRISPRCasFinder
TGGCACTTTGTTGGCATTCTGTTGGCACAA	CCTCGCCGGTACGCAGCGTGGTTACTGGGTTTGCGT
TGGCACTTTGTTGGCATTCTGTTGGCACAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018438.1\|WP_004230547.1\|3965431_3966847_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|274672
NZ_CP018438.1\|WP_004151305.1\|3970536_3971382_+\|phage-recombination-protein-Bet	unknown	unknown	gnl\|CDD\|273871
NZ_CP018438.1\|WP_004151295.1\|3965138_3965432_-\|protein-ren	unknown	unknown	gnl\|CDD\|238042
NZ_CP018438.1\|WP_004151286.1\|3961112_3961748_-\|recombination-protein-NinG	unknown	unknown	gnl\|CDD\|368603
NZ_CP018438.1\|WP_004151300.1\|3968598_3969288_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225484
NZ_CP018438.1\|WP_004151293.1\|3963686_3964529_-\|ead/Ea22-like-family-protein	unknown	unknown	gnl\|CDD\|379401
NZ_CP018438.1\|WP_004151306.1\|3971378_3972059_+\|YqaJ-viral-recombinase-family-protein	unknown	unknown	gnl\|CDD\|378216
NZ_CP018438.1\|WP_004151302.1\|3969850_3969961_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018438.1\|WP_004151298.1\|3967743_3967890_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018438.1\|WP_004151287.1\|3961740_3961911_-\|NinE-family-protein	unknown	unknown	gnl\|CDD\|182029
NZ_CP018438.1\|WP_004151301.1\|3969638_3969854_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018438.1\|WP_004151304.1\|3970236_3970521_+\|host-nuclease-inhibitor-GamL	unknown	unknown	unknown
NZ_CP018438.1\|WP_001548453.1\|3967975_3968197_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|336083
NZ_CP018438.1\|WP_004151294.1\|3964635_3965142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018438.1\|WP_004151291.1\|3962866_3963514_-\|DUF551-domain-containing-protein	unknown	unknown	gnl\|CDD\|367946
NZ_CP018438.1\|WP_004151292.1\|3963510_3963687_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018438.1\|WP_004151299.1\|3968237_3968471_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|374243
NZ_CP018438.1\|WP_004151285.1\|3960978_3961116_-\|YlcG-family-protein	unknown	unknown	unknown
NZ_CP018438.1\|WP_004151303.1\|3969953_3970148_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP018438.1\|WP_004151288.1\|3961910_3962366_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182057

Protein	Function_ID	Function_description	E-value
NZ_CP018438.1\|WP_004230547.1\|3965431_3966847_-\|AAA-family-ATPase	gnl\|CDD\|274672	TIGR03600, phage_DnaB, phage replicative helicase, DnaB family, HK022 subfamily. Members of this family are phage (or prophage-region) homologs of the bacterial homohexameric replicative helicase DnaB. Some phage may rely on host DnaB, while others encode their own verions. This model describes the largest phage-specific clade among the close homologs of DnaB, but there are, or course, other DnaB homologs from phage that fall outside the scope of this model. [Mobile and extrachromosomal element functions, Prophage functions].	9.32956e-159
NZ_CP018438.1\|WP_004151295.1\|3965138_3965432_-\|protein-ren	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	0.000668668
NZ_CP018438.1\|WP_004151286.1\|3961112_3961748_-\|recombination-protein-NinG	gnl\|CDD\|368603	pfam05766, NinG, Bacteriophage Lambda NinG protein. NinG or Rap is involved in recombination. Rap (recombination adept with plasmid) increases lambda-by-plasmid recombination catalyzed by Escherichia coli's RecBCD pathway.	9.44908e-60
NZ_CP018438.1\|WP_004151293.1\|3963686_3964529_-\|ead/Ea22-like-family-protein	gnl\|CDD\|379401	pfam13935, Ead_Ea22, Ead/Ea22-like protein. This family contains phage proteins and bacterial proteins that are likely to represent integrated phage proteins. This family includes the Lambda phage Ea22 early protein as well as the Bacteriophage P22 Ead protein.	0.000117969
NZ_CP018438.1\|WP_004151306.1\|3971378_3972059_+\|YqaJ-viral-recombinase-family-protein	gnl\|CDD\|378216	pfam09588, YqaJ, YqaJ-like viral recombinase domain. This protein family is found in many different bacterial species but is of viral origin. The protein forms an oligomer and functions as a processive alkaline exonuclease that digests linear double-stranded DNA in a Mg(2+)-dependent reaction, It has a preference for 5'-phosphorylated DNA ends. It thus forms part of the two-component SynExo viral recombinase functional unit.	1.68114e-32
NZ_CP018438.1\|WP_004151305.1\|3970536_3971382_+\|phage-recombination-protein-Bet	gnl\|CDD\|273871	TIGR01913, Uncharacterized_protein_UU154, phage recombination protein Bet. This model represents the phage recombination protein Bet from a number of phage, including phage lambda. All members of this family are found in phage genomes or in putative prophage regions of bacterial genomes. [Mobile and extrachromosomal element functions, Prophage functions].	3.75286e-34
NZ_CP018438.1\|WP_004151287.1\|3961740_3961911_-\|NinE-family-protein	gnl\|CDD\|182029	PRK09689, PRK09689, prophage protein NinE; Provisional.	1.47696e-19
NZ_CP018438.1\|WP_001548453.1\|3967975_3968197_-\|hypothetical-protein	gnl\|CDD\|336083	pfam05269, Phage_CII, Bacteriophage CII protein. This family consists of several phage CII regulatory proteins. CII plays a key role in the lysis-lysogeny decision in bacteriophage lambda and related phages.	1.55058e-09
NZ_CP018438.1\|WP_004151300.1\|3968598_3969288_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225484	COG2932, COG2932, Predicted transcriptional regulator [Transcription].	1.58097e-27
NZ_CP018438.1\|WP_004151291.1\|3962866_3963514_-\|DUF551-domain-containing-protein	gnl\|CDD\|367946	pfam04448, DUF551, Protein of unknown function (DUF551). This family represents the carboxy terminus of a protein of unknown function, found in dsDNA viruses with no RNA stage, including bacteriophages lambda and P22, and also in some Escherichia coli prophages.	8.71432e-11
NZ_CP018438.1\|WP_004151299.1\|3968237_3968471_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|374243	pfam15943, YdaS_antitoxin, Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT. YdaS_antitoxin is a family of putative bacterial antitoxins, neutralising the toxin YdaT, family pfam06254.	9.32854e-22
NZ_CP018438.1\|WP_004151288.1\|3961910_3962366_-\|hypothetical-protein	gnl\|CDD\|182057	PRK09741, PRK09741, hypothetical protein; Provisional.	1.50704e-78

>NZ_CP018438.1|WP_004230547.1|3965431_3966847_-|AAA-family-ATPase
MTPPHSIEAEQSVLGGLLLDDDNSERTQKVLSILKPESFYARPHQVIFAEMRQMYRDHKPVDLLTLFDALESKGLTETVGGFAYLAEMSKNTPSAANIVAYAMRVRETAMERYGIEKTTKAIELLYARNGMTAEQKFDAIQGLFTEITEHVKTGRRTGLRTFYDAVTDWSAEFDERLKPDGRSRGLSTGIRSLDELLGVKRIVRGSLFVIGARPKMGKTTLYTQMGINCATVENEPALMFSLEMPEGQMVEKITAQKGRISPNLFYPDMTKDDYGYRGDWNSDLQKATGVMGALIETNNLLIDDTPGISLAHVMAESRRIKRERGKVGMILVDYLTLMTADKAERNDLAYGLITKGLKILAKELDCVVVLLTQLNRDLEKRTNKRPLPSDSRDTGQIEQDCDYWLAIYREGAYDENANQSDTELLLRLNRHGETGVVYCEQRHGAIYDCDQEAASQRRREKEQKPTKRGGF
>NZ_CP018438.1|WP_004151295.1|3965138_3965432_-|protein-ren
MTGKDAILNYLKTHKTCSSPDVAAASGMTHTCINQAANILAKQGVLVAEARVWRTVYYRLATEEEIAGRKSTNQIFNECRQSPAMKRVLAVYGRTSA
>NZ_CP018438.1|WP_004151294.1|3964635_3965142_-|hypothetical-protein
MTITLQAVNKLIASMESAGELSIREQKFLKLAKEFRICSASLDAAIKTGNMLADQNAQLAAENVALKDINAWCKTDAFKNMYREFKTAEALGCSDADCMHDAMLVAIMHAPATPATDRIVAGIKADGVEEFAAKLRIPGDDQFFDALAKGIALAADDFAKQLREGADK
>NZ_CP018438.1|WP_004151293.1|3963686_3964529_-|ead/Ea22-like-family-protein
MTDITELAQSLKAAAEKASNGDWVKESGDGWEACCSANDQANGGFIIAHFVGPDAAENCEFVQAANPANVLALVEALEYYKSREERVTSLVRDNSKSWDELYRQVEAKGKRNVELVEALESEKRICATWRKTAESTSEKLEKAQAAERRWHRVASRVHEQACESDVKIDELEAIRAAAEKLVRCKGRYHSEQNYRALAALFGVNTPDLPPLEHENVHYADAAEMEIEALRQRIAELESRTVKLPPRVDSSNVPFAGNAWNCCLDEVEKRLTAAGIKMEAE
>NZ_CP018438.1|WP_004151292.1|3963510_3963687_-|hypothetical-protein
MAERWKIYLTIAFIGLGATPISMVAAKIDVPVWALIAGHCGATIAGFICAELGRGANQ
>NZ_CP018438.1|WP_004151291.1|3962866_3963514_-|DUF551-domain-containing-protein
MTNNQLAENSVIQLLNSVKLARDNAELADNRVDHSFYYALTIALEELQERRKAAMDSEPVLWAWHHLDMWHVTSHDGRARDLWLSGFKVIPLYRHAQPVLVIPDEMTAEQAYEIGYYYGDPVDVFARGANWMRQHIIDSTLAAAPQSPGSDPATVPGKWISVSERMPENDGAYLCWDNRYVTTYAFIFGAWQANQFIAKNITHWMPLPAGPQEVR
>NZ_CP018438.1|WP_004151288.1|3961910_3962366_-|hypothetical-protein
MNIPQCGIKLHNGNFSAIGKILQEQLSDGKCLRLQVKEWREKRSLSQNALSHMWYAEISEYLINSGRTDATPEWVKRNLKKTYLGCEEVTYTDFITGEKTTTWEPRHTSDLDTGEMHIFLTKVEAWCAQFGLALTIPHGCEYQQLQQKQEA
>NZ_CP018438.1|WP_004151287.1|3961740_3961911_-|NinE-family-protein
MSSLLAKVIERGIFRVPARRKRKVEDKPSDIPTLKDYTARLVDKKWLRLRARRPHA
>NZ_CP018438.1|WP_004151286.1|3961112_3961748_-|recombination-protein-NinG
MRKPARRKCAHCREWFHPAREGQVVCSFECASAIGKKQTAKAREAAKARAVKRQRESEKEGRQRRKARLAELRPNGYYKAQAQKAFNAYIRARDAALPCISCGETNPPDLHGGQWDCGHFKTVGAYPELRFEERNAHKQCKSCNAGAGKYTAKELTVAQQYEAGLVARYGQEYVDWLNGPHEMTNYRREDFIRIRDEYRAKLKALKQREAA
>NZ_CP018438.1|WP_004151285.1|3960978_3961116_-|YlcG-family-protein
MNHDIIERIRDRWKKLRLLRSRGTVLVDYLILRNFIASLSRGSYE
>NZ_CP018438.1|WP_004151298.1|3967743_3967890_-|hypothetical-protein
MPKSNRFYQAQTHKNVTRDRFIRSVNPVVGMKMRAILEELKRKEEGRE
>NZ_CP018438.1|WP_001548453.1|3967975_3968197_-|hypothetical-protein
MESSTTRNKVEARRIESWLHSQIAELGTTNIAKVAGVNKSTVSRWRESLLPNMSLLLAILISNRPGEKGDFEA
>NZ_CP018438.1|WP_004151299.1|3968237_3968471_-|helix-turn-helix-domain-containing-protein
MKNPAVEKAISIAGSQKELAKRCGKAQSTICDWLNGKKRISPVHVPDLVAAVNGEIKAYEFRPDLPSIFPPPNNSAA
>NZ_CP018438.1|WP_004151300.1|3968598_3969288_+|helix-turn-helix-transcriptional-regulator
MDFSERLARAMSLAGYTQGRLAKEVGMAQSSVNKLLNGANGSRKTVEIASVLGVRPEWLSTGAGEMLADSIQITQMQTPVTPQNGIYRVDVLDVKASAGPGALITNDFIETIRAIEYTSEQARSLFGNRPAHHIKVITVTGDSMDTTISPGDEIFVDISSTHFDSDGVYVFVFGKTLHVKRLQMQRDRLAVISDNPIYEKWYVEPGDEDQFYVMARVLLRQSIEYKRFA
>NZ_CP018438.1|WP_004151301.1|3969638_3969854_+|hypothetical-protein
MSKENNGGPAYPTQGYEGLTVRDYFAAKAMQGWLAGYPAGINHPARSEEGFTVAELSYLMADAMLKAREEV
>NZ_CP018438.1|WP_004151302.1|3969850_3969961_+|hypothetical-protein
MSKQGIRSLIYCLLICGVIWSAVVIKILHATGVFNG
>NZ_CP018438.1|WP_004151303.1|3969953_3970148_+|hypothetical-protein
MANSIPNNGRAVMMRNRRTGAAWLVSFDYRDGSYWHEPQGNLRHIRRPYASRSIEPNLVPAGTH
>NZ_CP018438.1|WP_004151304.1|3970236_3970521_+|host-nuclease-inhibitor-GamL
MNAYRAYDVIEERKWAEQTLTEEKQKWIEDRAKEVFDSLPEDPYAALRQSVSSKSFPYEGLRSDKAGEVYNDLRTAIAYAQAEYDWDHRTGCPF
>NZ_CP018438.1|WP_004151305.1|3970536_3971382_+|phage-recombination-protein-Bet
MANELVITASSLAERGIDGATWSALKNSIYPGAKDESVMMALDYCRARNLDPLLKPVHLVPMSVKDSKSGKSEWRDVVMPGIGLYRIQADRSGDYAGAKEPEFGPDVTLTLTGIEVTVPQWCKYTVSKRMPSGEIVEFSAKEYWVENYATAGRDTTAPNAMWKKRPYGQLAKCAEAQALRKAWPEIGQQPTAEEMEGKTLEVDARDVTPRSTPEAPPLVASEETLQAITDLLTSLNKDWEQDFLPLCSNIFKRDIFQASQLTEEEAQKGFSFLQKKAQVAA
>NZ_CP018438.1|WP_004151306.1|3971378_3972059_+|YqaJ-viral-recombinase-family-protein
MTPEIILERTGIDVTRVEQGDESWHRLRLGVITASEVHNVISKPKSGKKWTDMKMSYFLTLLAEVCTGVAPEVNAKALAWGKQYEADARTLFEFTTDVKVTESPILFRDEGMRTACSPDGLCSDGRGLELKCPFTSRDFMKFRLGGFEAIKSAYMAQVQFSMWVTGKDAWYFANYDPRMKREGIHHVVVERDDKYMSDFNEMVPEFISKMDESLAEIGFTFGEQWK

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Crispr_ID: NZ_CP018438_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP018438_2

4452538-4452632

Orphan

Consensus_repeat	Method
ACTATGGTTTTTATGGTTTTTATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP018438_2

>merge|NZ_CP018438|2|4452538-4452632|CRISPRCasFinder
TTAATGGTCACTATGGTTTTTATGGTTTTTATTCGCTGAACTGCCCGGGAGTGATATATCTCTGATTTATGACTGTGGTTTTTATGGTTTTTATT

>NZ_CP018438|2|2|4452538-4452632|CRISPRCasFinder
TTAATGGTCACTATGGTTTTTATG	GTTTTTATTCGCTGAACTGCCCGGGAGTGATATATCTCTGATTTATG
ACTGTGGTTTTTATGGTTTTTATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018438.1\|WP_002888323.1\|4461695_4462073_+\|Co2+/Mg2+-efflux-protein-ApaG	unknown	unknown	gnl\|CDD\|180098
NZ_CP018438.1\|WP_002888332.1\|4455119_4455947_-\|co-chaperone-DjlA	unknown	unknown	gnl\|CDD\|236512
NZ_CP018438.1\|WP_004151368.1\|4446712_4449619_+\|RNA-polymerase-associated-protein-RapA	unknown	unknown	gnl\|CDD\|235319
NZ_CP018438.1\|WP_002888345.1\|4451084_4452449_-\|2-hydroxycarboxylate-transporter-family-protein	unknown	unknown	gnl\|CDD\|377030
NZ_CP018438.1\|WP_004147026.1\|4456190_4458539_+\|LPS-assembly-protein-LptD	unknown	unknown	gnl\|CDD\|235158
NZ_CP018438.1\|WP_002888357.1\|4441656_4443159_+\|L-arabinose-isomerase	unknown	unknown	gnl\|CDD\|179503
NZ_CP018438.1\|WP_002888329.1\|4458593_4459880_+\|peptidylprolyl-isomerase-SurA	unknown	unknown	gnl\|CDD\|236758
NZ_CP018438.1\|WP_002888349.1\|4444167_4446525_+\|DNA-polymerase-II	unknown	unknown	gnl\|CDD\|235595
NZ_CP018438.1\|WP_002888353.1\|4443296_4443992_+\|L-ribulose-5-phosphate-4-epimerase	unknown	unknown	gnl\|CDD\|236181
NZ_CP018438.1\|WP_002888321.1\|4462077_4462926_+\|bis(5'-nucleosyl)-tetraphosphatase-(symmetrical)-ApaH	unknown	unknown	gnl\|CDD\|273208
NZ_CP018438.1\|WP_002888368.1\|4439936_4441646_+\|ribulokinase	unknown	unknown	gnl\|CDD\|235221
NZ_CP018438.1\|WP_002888340.1\|4452773_4454399_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225827
NZ_CP018438.1\|WP_002888347.1\|4450365_4450905_-\|citrate-lyase-holo-[acyl-carrier-protein]-synthase	unknown	unknown	gnl\|CDD\|163145
NZ_CP018438.1\|WP_002888373.1\|4437857_4438625_-\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP018438.1\|WP_002888324.1\|4460871_4461693_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NZ_CP018438.1\|WP_002888327.1\|4459885_4460875_+\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	unknown	unknown	gnl\|CDD\|234696
NZ_CP018438.1\|WP_002888370.1\|4438753_4439599_-\|arabinose-operon-transcriptional-regulator-AraC	unknown	unknown	gnl\|CDD\|236717
NZ_CP018438.1\|WP_002888348.1\|4449631_4450291_+\|bifunctional-tRNA-pseudouridine(32)-synthase/23S-rRNA-pseudouridine(746)-synthase-RluA	unknown	unknown	gnl\|CDD\|236659
NZ_CP018438.1\|WP_002888337.1\|4454388_4455087_+\|response-regulator	unknown	unknown	gnl\|CDD\|226931
NZ_CP018438.1\|WP_002888320.1\|4463181_4463661_-\|type-3-dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|182714

Protein	Function_ID	Function_description	E-value
NZ_CP018438.1\|WP_002888323.1\|4461695_4462073_+\|Co2+/Mg2+-efflux-protein-ApaG	gnl\|CDD\|180098	PRK05461, apaG, CO2+/MG2+ efflux protein ApaG; Reviewed.	7.84855e-74
NZ_CP018438.1\|WP_002888332.1\|4455119_4455947_-\|co-chaperone-DjlA	gnl\|CDD\|236512	PRK09430, djlA, co-chaperone DjlA.	2.63694e-164
NZ_CP018438.1\|WP_004151368.1\|4446712_4449619_+\|RNA-polymerase-associated-protein-RapA	gnl\|CDD\|235319	PRK04914, PRK04914, RNA polymerase-associated protein RapA.	0
NZ_CP018438.1\|WP_002888345.1\|4451084_4452449_-\|2-hydroxycarboxylate-transporter-family-protein	gnl\|CDD\|377030	pfam03390, 2HCT, 2-hydroxycarboxylate transporter family. The 2-hydroxycarboxylate transporter family is a family of secondary transporters found exclusively in the bacterial kingdom. They function in the metabolism of the di- and tricarboxylates malate and citrate, mostly in fermentative pathways involving decarboxylation of malate or oxaloacetate.	4.87969e-169
NZ_CP018438.1\|WP_004147026.1\|4456190_4458539_+\|LPS-assembly-protein-LptD	gnl\|CDD\|235158	PRK03761, PRK03761, LPS assembly outer membrane complex protein LptD; Provisional.	0
NZ_CP018438.1\|WP_002888357.1\|4441656_4443159_+\|L-arabinose-isomerase	gnl\|CDD\|179503	PRK02929, PRK02929, L-arabinose isomerase; Provisional.	0
NZ_CP018438.1\|WP_002888329.1\|4458593_4459880_+\|peptidylprolyl-isomerase-SurA	gnl\|CDD\|236758	PRK10770, PRK10770, peptidyl-prolyl cis-trans isomerase SurA; Provisional.	0
NZ_CP018438.1\|WP_002888349.1\|4444167_4446525_+\|DNA-polymerase-II	gnl\|CDD\|235595	PRK05762, PRK05762, DNA polymerase II; Reviewed.	0
NZ_CP018438.1\|WP_002888353.1\|4443296_4443992_+\|L-ribulose-5-phosphate-4-epimerase	gnl\|CDD\|236181	PRK08193, araD, L-ribulose-5-phosphate 4-epimerase AraD.	0
NZ_CP018438.1\|WP_002888321.1\|4462077_4462926_+\|bis(5'-nucleosyl)-tetraphosphatase-(symmetrical)-ApaH	gnl\|CDD\|273208	TIGR00668, Bis5'-nucleosyl-tetraphosphatase_symmetrical, bis(5'-nucleosyl)-tetraphosphatase (symmetrical). Diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) is a regulatory metabolite of stress conditions. It is hydrolyzed to two ADP by this enzyme. Alternate names include diadenosine-tetraphosphatase and Ap4A hydrolase. [Cellular processes, Adaptations to atypical conditions].	0
NZ_CP018438.1\|WP_002888368.1\|4439936_4441646_+\|ribulokinase	gnl\|CDD\|235221	PRK04123, PRK04123, ribulokinase; Provisional.	0
NZ_CP018438.1\|WP_002888340.1\|4452773_4454399_+\|sensor-histidine-kinase	gnl\|CDD\|225827	COG3290, CitA, Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms].	6.55037e-173
NZ_CP018438.1\|WP_002888347.1\|4450365_4450905_-\|citrate-lyase-holo-[acyl-carrier-protein]-synthase	gnl\|CDD\|163145	TIGR03124, citrate_citX, holo-ACP synthase CitX. Members of this protein family are the CitX protein, or CitX domain of the CitXG bifunctional protein, of the citrate lyase system. CitX transfers the prosthetic group 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA to the citrate lyase gamma chain, an acyl carrier protein. This enzyme may be designated holo-ACP synthase, holo-citrate lyase synthase, or apo-citrate lyase phosphoribosyl-dephospho-CoA transferase. In a few genera, including Haemophilus, this protein occurs as a fusion protein with CitG (2.7.8.25), an enzyme involved in prosthetic group biosynthesis. This CitX family is easily separated from the holo-ACP synthases of other enzyme systems. [Energy metabolism, Fermentation, Protein fate, Protein modification and repair].	5.54697e-86
NZ_CP018438.1\|WP_002888373.1\|4437857_4438625_-\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	1.35562e-48
NZ_CP018438.1\|WP_002888324.1\|4460871_4461693_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	3.65731e-147
NZ_CP018438.1\|WP_002888327.1\|4459885_4460875_+\|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA	gnl\|CDD\|234696	PRK00232, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed.	0
NZ_CP018438.1\|WP_002888370.1\|4438753_4439599_-\|arabinose-operon-transcriptional-regulator-AraC	gnl\|CDD\|236717	PRK10572, PRK10572, arabinose operon transcriptional regulator AraC.	0
NZ_CP018438.1\|WP_002888348.1\|4449631_4450291_+\|bifunctional-tRNA-pseudouridine(32)-synthase/23S-rRNA-pseudouridine(746)-synthase-RluA	gnl\|CDD\|236659	PRK10158, PRK10158, bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA.	2.4454e-161
NZ_CP018438.1\|WP_002888337.1\|4454388_4455087_+\|response-regulator	gnl\|CDD\|226931	COG4565, CitB, Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms].	5.03078e-66
NZ_CP018438.1\|WP_002888320.1\|4463181_4463661_-\|type-3-dihydrofolate-reductase	gnl\|CDD\|182714	PRK10769, folA, type 3 dihydrofolate reductase.	1.71656e-127

>NZ_CP018438.1|WP_002888345.1|4451084_4452449_-|2-hydroxycarboxylate-transporter-family-protein
MSTTDNAFSATLEPIDTPKTTLKQRWWHIMDNWKVGIVPLPLFLLAGGLIALDCLGGKLPSDIVVMVATLAFFGFACGEFGKRLPVLGKLGAAAICATFIPSALVHYGLLPDVVIESTTKFYKSTNILYLYICCIIVGSIMSMNRTTLIQGFLKIFFPMLCGEVVGMLVGIGVGTLLGMEPFQVFFFIVLPIMAGGVGEGAIPLSMGYAALMHMEQGVALGRVLPMVMLGSLTAIVISGCLNQLGKRFPHLTGEGQLMPNRSHETRSLSESEGVSGKTDVGTLASGALLAVLLYMMGMLGHKLIGLPAPVGMLFLAVLLKLANVVSPRLQEGSQMVYKFFRTAVTYPILFAVGVAITPWQELVNAFTLTNLLVIVSTVSALVATGFLVGKKIGMHPIDVAIVSCCQSGQGGTGDVAILTAGNRMSLMPFAQIATRIGGAINVSLGLLFLSHYLA
>NZ_CP018438.1|WP_002888347.1|4450365_4450905_-|citrate-lyase-holo-[acyl-carrier-protein]-synthase
MSVDTPAQAGVSIDALLAAKEQRAARQADWLAHYQQPVISLTLVTPGAVKDSIRYRNMMGVALQACDQLLWKHRWQTLDRQVLWLPTGPEALWCVAHPASEIKAMCSTLEQSHPLGRLWDIDVICPQNGLVGRQSLGESQRRCLLCDEPAHACARSRRHDTDLVVARVEQMIDAWFARD
>NZ_CP018438.1|WP_002888348.1|4449631_4450291_+|bifunctional-tRNA-pseudouridine(32)-synthase/23S-rRNA-pseudouridine(746)-synthase-RluA
MAMENYNPPQDPWLVILYQDEHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDFPQAESVHRLDMATSGVIVVALNKAAERELKRQFREREPKKQYVARVWGHPQPAEGLVDLPLICDWPNRPKQKVCYETGKAAQTEYEVLEYAEDNTARVRLKPITGRSHQLRVHMLALGHPILGDRFYATPEALAMAPRLLLHAETLTITHPAYGNAMTFRAPIDF
>NZ_CP018438.1|WP_004151368.1|4446712_4449619_+|RNA-polymerase-associated-protein-RapA
MPFTLGQRWISDTESELGLGTVVALDARMVTLLFPAIGENRLYSRNDSPITRVMFNPGDTITSHEGWQLHVDKVNEENGLLSYTGTRLDTQEANVTLREVLLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKFQSEQYRMPWSGLRGQRTSLIPHQLHIAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAAERVLIVVPETLQHQWLVEMLRRFNLRFSLFDDERYAEAQHDAYNPFETEQLVICSLDFVRRSKQRLEHLCDAEWDLMVVDEAHHLVWSEEAPSREYQAIEQLAERVPGILLLTATPEQLGMESHFARLRLLDPNRFHDFEQFVEEQQNYRPVADAVALLLAGNKLSDSELNTLGDLIGEQDIEPLLQAANSDREDAQAARQELISMLMDRHGTSRVLFRNTRNGVKGFPKRELHTIRLPLPTQYQTAIKVSGIMGARKTAEERARDMLYPEQIYQEFEGDTGTWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASNLVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRTVYDSVHDELINYLAAPESIDGFDDLIKSCRQQHDALKAQLEQGRDRLLEIHSNGGEKAQALAESIEEQDDDTSLIAFSMNLFDIVGINQDDRGENLIVLTPSDHMLVPDFPGLPEDGCTITFERDVALSREDAQFITWEHPLIRNGLDLILSGDTGSSTISLLKNKALPVGTLLLELIYVVEAQAPKQLQLNRFLPATPVRMLLDKNGNNLAAQVEFESFNRQLSAVNRHTGSKLVNAVQQDVHAILQQGEAQIAKAAQGLIDAARNEADEKLTAELSRLEALKAVNPNIRDDELAGIESNRQQVMDALAQAGWRLDALRLIVVTHQ
>NZ_CP018438.1|WP_002888349.1|4444167_4446525_+|DNA-polymerase-II
MTQPRAGFLLTRHWRDTPQGTELSFWLATDDGPLQVTLPPQESVAFIPEAQRAQAERLLQGEKGLRFAPLALKDFHRQPIVGLYCRAHRQLMRLEKMLRDSGVTVYEGDIRPPERYLMERFITAPVWVEGETRGSQLVNARMKPNPDYRPPLKWVSLDIETSRHGELYCIGLEGCGQRVVYMLGPEPETPPDVDFELVFIASRPLLLEKLNAWFAEHDPDVLIGWNVVQFDLRVLQKHAERYRIPLRLGRGNSELEWREHGFKNGVFFAQANGRLIIDGIDALKSAFWNFSSFSLEAVARELLGEGKAIDNPWDRMDEIDRRFHEDKPALAIYNLQDCELVTRIFHKTEIMPFLLERATVNGLPADRHGGSVAAFSHLYFPRMHRLGYVAPNLGDVPPQASPGGYVMDSRPGLYDSVLVLDYKSLYPSIIRTFLIDPVGLIEGLAQPDDQHSIEGFLGARFSRDKHCLPGIVSQIWHGRDEAKRQHNKPLSQALKIIMNAFYGVLGTSACRFFDPRLASSITMRGHAIMRQTKALIEAKGYDVIYGDTDSTFVWLKRPHSEAQAAEIGRELVSHVNAWWAQELSKSQLTSALELEYETHFCRFLMPTIRGADTGSKKRYAGMIQEGDAQRMVFKGLETVRTDWTPLAQQFQQELYLRIFRNQPYQDYVRETIARLMNGELDEQLVYRKRLRRPLAEYQRNVPPHVRAARLADEHNLKLGRAQQYQQRGTIKYVWTTSGPEPVDYQQSPLDYDHYLTKQLQPVAEGILPFVNDDFATIVTGQLGLF
>NZ_CP018438.1|WP_002888353.1|4443296_4443992_+|L-ribulose-5-phosphate-4-epimerase
MLEDLKRQVLEANLALPKHNLVTLTWGNVSAVDREKGVFVIKPSGVDYRVMTADDMVVVSLESGEVVEGNKKPSSDTPTHRLLYQAFPTLGGIVHTHSRHATIWAQAGQSIPATGTTHADYFYGPVPCTRLMTDAEINGDYEWETGNVIVETFRQQGIDPAQMPGVLVHSHGPFAWGKNAEDAVHNAIVLEEIAYMGIFCRQLAPQLPAMQQTLLDKHYLRKHGAKAYYGQ
>NZ_CP018438.1|WP_002888357.1|4441656_4443159_+|L-arabinose-isomerase
MTIFDNYEVWFVIGSQHLYGPEALRQVTKHAEHVVNSLNAEAKLPCKLVLKPLGTTPDEITHICRDANYDDKCAGLVVWLHTFSPAKMWINGLTILNKPLLQFHTQYNAALPWDSIDMDFMNLNQTAHGGREFGFIGARMRQQHSVVTGHWQDKEAHQRIGGWMRQAVSKQDTRHLKVCRFGDNMREVAVTDGDKVAAQIKFGFSVNTWAVGDLVQVVNSISDGDISALVDEYESSYRLTPAAQVHGEKRQNVLDAARIELGMKRFLEQGGFHAFTTTFEDLHGLKQLPGLAVQRLMQQGYGFAGEGDWKTAALLRIMKVMSTGLQGGTSFMEDYTYHFDNGNDLVLGSHMLEVCPTIATVEKPILDVQPLGIGGKADPARLIFNTQTGPAIVASLIDLGDRFRLLVNTIETVPTPHDLPKLPVANALWKAQPDLRTASEAWIIAGGAHHTVFSHALNLDDMRQFAELHDIELTVIDNDTRLPSFKDALRWNEVYYGSKR
>NZ_CP018438.1|WP_002888368.1|4439936_4441646_+|ribulokinase
MAIAIGLDFGSDSVRALAVECASGAELATSVEWYPRWREGQYCDGANNRFRHHPRDYIESMEAALKSVLASLSAEQRADVVGIGVDSTGSTPAPVDAEGNVLALREEFADNPNAMFVLWKDHTAVEEAEAITRLCHQPGKEDYSRYIGGIYSSEWFWAKILHVTREDSAVAQAAASWVELCDWVPALLSGTTRPQDLRRGRCSAGHKSLWHESWGGLPPASFFDELDPIINQHLAWPLFTDTWTADVPVGTLSAEWAQRLGLSQSVAISGGAFDCHMGAVGAGAQPNALVKVIGTSTCDILIADKESVGERTVKGICGQVDGSVVPHFIGMEAGQSAFGDIYAWFGRILGWPLEQLAQQQPALREQIKASQKQLLPALTEAWANNPSLEHLPVVLDWFNGRRTPNANQRLKGVITDLNLATDAPALFGGLIAATAFGARAIMECFTEQGIPVNNVMALGGIARKNQVIMQACCDVLNRPLQIVASDQCCALGAAIFAAVAAGVYDDIPAAQQRMASQVETTLQPRPAQAQRFEQLYQRYQQWSVSAEQHYLPSAAKAEKAPQSKAALTH
>NZ_CP018438.1|WP_002888370.1|4438753_4439599_-|arabinose-operon-transcriptional-regulator-AraC
MAETQNDPLLPGYSFNAHLVTGLTPIEAQGYLDFFIDRPLGMKGYILNLTIRGEGVINNHGEQFVCRPGDMLLFPPGEIHHYGRHPDASEWYHQWVYFRPRAYWHEWLNWPTIFAQTGFFRPDEQWQARFGELFGQIVDAGQGAGRYSELLAINLLEQLLLRRMEAINESLHPPLDNRVREACQYISDHLADSHFDIASVAQHVCLSPSRLSHLFRQQLGVSVLGWREDQRISQAKLLLSTTRMPIATVGRNVGFEDQLYFSRVFKKCTGASPSEFRAGCE
>NZ_CP018438.1|WP_002888373.1|4437857_4438625_-|DedA-family-protein
MQALLEHFITQSTVYSLLAVMLVAFLESLALVGLILPGTVMMAGLGALIGGGEVNFWQAWLAGIVGCLLGDWISFWLGWRFKKPLHRWSFMKKNRALLEKTEHALHQHSMITILIGRFVGPTRPLVPMVAGMLDLPVAKFVLPNIIGCLLWPPLYFLPGILAGAAIDIPADENSASFKWLLLGAALLAWLAGWLCWRLWRSAKTSGDRLTRWLPRGRLLWLSPLMVALAATALTFVFRHPLMPVYLAILHKVIAR
>NZ_CP018438.1|WP_002888340.1|4452773_4454399_+|sensor-histidine-kinase
MKLSFQYKLFISLVAFFSVLFIALGIYYYFDASRQLYQEMSARAKIQAEEIALMPNLRQQVSRHDPQAIQAFMQQIAAHSDASFIVIGDRQGVHLFHSVHPEWVGTRLVGGDNQAVLEGKSITTIRKGGLGVSLRSKTPIVDDAGRVIGIVSVGYLTSYLDSITLTKVINIFIAAVLLLIALFIFSWYFTRSIKKQIFSLEPREIGLLVRQQKAMMESIFEGVIVIDRQRRIEVINHAARSLLGLSQPARQLRGQSIDSVISPQPFFASGDMLERDTHDELCRFNQLTVLASRVRIMLENTLQGWVITFRDRNEINALTAQLSQVKRYVDNLRIMRHEQLNRMTTLSGLLHMGHYDEAIRYIQAQSEHAQELLDFISSHFHSPTLCGLLLGKATRAREKGVALSFDPACRIDRPLPSLMESELISIIGNLLDNAIEATQRAELPHEPVEVLIQLNARELIIEVADRGVGIRPDIRERIFERGVTTKTRGDHGIGLYLIEHYVTQAGGTIEVADNAPRGTIFTLFIPADAHACPQPEAHDAS
>NZ_CP018438.1|WP_002888337.1|4454388_4455087_+|response-regulator
MHHDLVDVLIIEDESELARLHAELVQKHPRLRLAGMAASLAQARQLLHATPPQLVLLDNYLPDGKGVTLMTDPALATSQCSVIFITAASDMETCSQAIRNGAFDYILKPVSWKRLSQSLERFIQFYDQQREWKIVDQQNVDSLYQLQAKNYRVDSGSKGIEEKTLALVQGLFSDREAHCFSVDEVVSAAGLSKTTARRYLEHGVETGFLEVEMLYGKIGHPRRLYRRAKVKS
>NZ_CP018438.1|WP_002888332.1|4455119_4455947_-|co-chaperone-DjlA
MQYLGKVIGVAVALLMGGGFWGVVLGFLVGHMFDRARSRRLNLFANQQERQSLFFSTTFEVMGHLTKSKGRVTEADIHVANVLMDRMNLHGASRTAAQQAFRDGKADNYPLREKMRQLRSVCFGRFDLIRMFLEIQLQAAFADGELHPNEREVLFVIADELGISRAQFDQFLRMMQGGAQFGGGSQQRSYGQHGGNAGWQQAQRGPTLEDACNVLGVKPTDDAATVKRAYRKLMNEHHPDKLVAKGLPPEMMEMAKQKAQEIQKAWELIKEQRGF
>NZ_CP018438.1|WP_004147026.1|4456190_4458539_+|LPS-assembly-protein-LptD
MKKRIPSLLATMIASALYSQQGLAADLATQCMLGVPSYDRPLVEGRPGDLPVTINADHAKGNYPDNAVFTGNVDINQGNSRLRADEVQLHQQQAAGQAQPVRTVDALGNVHYDDNQVILKGPKAWSNLNTKDTNVWQGDYQMVGRQGRGTADLMKQRGENRYTILENGSFTSCLPGSDTWSVVGSEVIHDREEQVAEIWNARFKLGSVPIFYSPYLQLPVGDKRRSGFLIPNAKYSTKNGVEFSLPYYWNIAPNFDATITPHYMNKRGGVMWENEFRYLTQLGSGLTEFDYLPSDKVYEDDHSSDSNSRRWLFYWNHSGVIDQVWRLNADYTKVSDPDYFNDFSSKYGSSTDGYATQKFSAGYVNQNFDATVSTKQFQVFDRESSNSYSAEPQLDVNYYQNDVGPFDTHLYGQVAHFVNSNNNMPEATRVHFEPTINLPLSNGWGSLNTEAKLLATHYQQSNLDKYNAANGTDYKESVSRVMPQFKVDGKMVFERDLQEGFTQTLEPRVQYLYVPYRDQSEIGNYDSTLLQSDYTGLFRDRTYSGLDRIASANQVTTGLTSRVYDAAAVERFNISVGQIYYFTESRTGDDNINWENNDTTGSLVWAGDTYWRIADEWGLRGGIQYDTRLDNVATGNGTIEYRRDENRLVQLNYRYASPEYIQATLPSYSTAAQYKQGISQVGMTASWPIVDRWSVVGAYYYDTNTRKAANQMLGVQYNSCCYAIRLGYERKVNGWNSNDNGGESKYDNTFGINIELRGLSSNYGLGTQQMLRSNILPYQSSL
>NZ_CP018438.1|WP_002888329.1|4458593_4459880_+|peptidylprolyl-isomerase-SurA
MKNWKTLLLGIAMIANTSFAAPQVVDKVAAVVNNGVVLESDVDGLMQSVKLNAGQAGQQLPDDATLRHQILERLIMDQIVLQMGQKMGVKISDDQLDQAIANIAKQNNMTLDQMRSRLAYEGINYNTYRNQIRKEMLISEVRNNEVRRRITVLPQEVEALAKQIGDQNDASTELNLSHILIPLPENPTSDEVAAAQEQANSIVEQARNGANFGKLAITYSADQQALKGGQMGWGRIQELPGIFAQALSTAKKGDIVGPIRSGVGFHILKVNDLRGGTQNISVTEVHARHILLKPSPIMNDAQAQAKLEQIAAEIKSGKITFAQAAKTYSEDPGSANQGGDLGWATPDIFDPAFRDALMRLNKGQTSGPVHSSFGWHLIELLDSRQVDRTDAAQKDRAYRMLMNRKFSEEAATWMQEQRASAYVKILSN
>NZ_CP018438.1|WP_002888327.1|4459885_4460875_+|4-hydroxythreonine-4-phosphate-dehydrogenase-PdxA
MPETRKVVITPGEPAGIGPDLVVQLAQRDWPVELVICADGALLTDRAKRLGLPLSLLPYDPAQPPVPQRAGTLTLLNVPLNVPAEPGVLNVQNGAYVVETLARACDGCLSGEFAALVTGPVHKGNINDAGIAFTGHTEFFEERAKASKVVMMLATEELRVALVTTHLPLKAISEAITPELLREIITILDHDLRTKFGIAQPHVLVCGLNPHAGEGGHMGTEEIDTIIPVLEEMRAKGMNLSGPLPADTLFQPKYLDHADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGQGKADVGSFITALNLAIKMIVNTQ
>NZ_CP018438.1|WP_002888324.1|4460871_4461693_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MNNRVHQGHLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTMNFGELAEKMGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCQVIPVLEVPPSAFTPPPKVDSAVVRLVPHSTMPYPVKEIRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTELGIDPAMRAENISVAQYCLMANWLSDNLPTKES
>NZ_CP018438.1|WP_002888323.1|4461695_4462073_+|Co2+/Mg2+-efflux-protein-ApaG
MIHSPRVCVQVQSVYIESQSSPEEERYVFAYTVTIRNLGRSQVQLLGRYWLITNGHGRETEVQGEGVVGEQPHIPAGGEYQYTSGAVIETPLGTMQGHYEMIDIDGAPFRIEIPVFRLAVPTLIH
>NZ_CP018438.1|WP_002888321.1|4462077_4462926_+|bis(5'-nucleosyl)-tetraphosphatase-(symmetrical)-ApaH
MSTYLIGDVHGCYDELIALLAQVEFDPRRDTLWLTGDLVARGPGSLEVLRYVKSLGDSVRLVLGNHDLHLLAVFAGISRNKPKDRLKPLLEAPDADELLNWLRRQPLLQVDEEKKLVMAHAGITPQWDLETAQQCARDVEAVLSSDSYPFFLDAMYGDMPNHWSNELSGLARLRFISNAFTRMRYCFPNGQLDMYSKEAPEDAPAPLKPWFAIPGPVSNAYSIAFGHWASLEGRGTPEGIYALDTGCCWGGELTCLRWEDKQYFTQPSNRQKSLDEGEAVAS
>NZ_CP018438.1|WP_002888320.1|4463181_4463661_-|type-3-dihydrofolate-reductase
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNIVISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Identity
NZ_CP018438_1	1.1\|3967292\|36\|NZ_CP018438\|CRISPRCasFinder	3967292-3967327	36	MK448233	Klebsiella phage ST11-VIM1phi8.1, complete genome	8447-8482	1.0
NZ_CP018438_1	1.1\|3967292\|36\|NZ_CP018438\|CRISPRCasFinder	3967292-3967327	36	MK448235	Klebsiella phage ST512-KPC3phi13.1, complete genome	8447-8482	1.0
NZ_CP018438_1	1.1\|3967292\|36\|NZ_CP018438\|CRISPRCasFinder	3967292-3967327	36	MK448231	Klebsiella phage ST101-KPC2phi6.1, complete genome	11383-11418	1.0

1. spacer 1.1|3967292|36|NZ_CP018438|CRISPRCasFinder matches to MK448233 (Klebsiella phage ST11-VIM1phi8.1, complete genome) position: , mismatch: 0, identity: 1.0

cctcgccggtacgcagcgtggttactgggtttgcgt	CRISPR spacer
cctcgccggtacgcagcgtggttactgggtttgcgt	Protospacer
************************************

2. spacer 1.1|3967292|36|NZ_CP018438|CRISPRCasFinder matches to MK448235 (Klebsiella phage ST512-KPC3phi13.1, complete genome) position: , mismatch: 0, identity: 1.0

cctcgccggtacgcagcgtggttactgggtttgcgt	CRISPR spacer
cctcgccggtacgcagcgtggttactgggtttgcgt	Protospacer
************************************

3. spacer 1.1|3967292|36|NZ_CP018438|CRISPRCasFinder matches to MK448231 (Klebsiella phage ST101-KPC2phi6.1, complete genome) position: , mismatch: 0, identity: 1.0

cctcgccggtacgcagcgtggttactgggtttgcgt	CRISPR spacer
cctcgccggtacgcagcgtggttactgggtttgcgt	Protospacer
************************************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

444765 : 478023

uncultured_Caudovirales_phage(75.0%)

tRNA,portal,terminase,capsid,head,tail,protease,integrase

attL 462373:462390|attR 478368:478385

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002919147.1\|444765_445713_-\|tRNA	methionyl-tRNA formyltransferase	E3SNR5	Prochlorococcus_phage	2.2e-07	37.2
WP_002919144.1\|445727_446237_-	peptide deformylase	E3SLL2	Synechococcus_phage	2.6e-18	40.3
WP_002919139.1\|446365_447490_+	DNA-protecting protein DprA	NA	NA	NA	NA
WP_002919137.1\|447461_447935_+	DUF494 domain-containing protein	NA	NA	NA	NA
WP_004145330.1\|447960_448503_+	topoisomerase DNA-binding C4 zinc finger domain-containing protein	NA	NA	NA	NA
WP_002919132.1\|448507_449080_+	L-threonylcarbamoyladenylate synthase type 1 TsaC	NA	NA	NA	NA
WP_073545598.1\|449083_449902_+	shikimate dehydrogenase	NA	NA	NA	NA
WP_002919125.1\|449898_450156_+	DUF1488 domain-containing protein	NA	NA	NA	NA
WP_002919123.1\|450131_450686_-	gamma carbonic anhydrase family protein	NA	NA	NA	NA
WP_002919103.1\|456481_456703_-	membrane protein	NA	NA	NA	NA
WP_002919102.1\|456996_460107_-	multidrug efflux RND transporter permease subunit	NA	NA	NA	NA
WP_002919101.1\|460119_461259_-	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_004150972.1\|461637_462288_+	acrEF/envCD operon transcriptional regulator	NA	NA	NA	NA
462373:462390	attL	NA	NA	NA	NA
WP_004150971.1\|462563_463790_+\|integrase	site-specific integrase	A0A2H4JB45	uncultured_Caudovirales_phage	1.8e-150	62.2
WP_004150970.1\|463882_464824_+	hypothetical protein	NA	NA	NA	NA
WP_001547839.1\|465005_465290_+	AlpA family phage regulatory protein	NA	NA	NA	NA
WP_004150969.1\|465300_466080_+	phage antirepressor KilAC domain-containing protein	Q8HA02	Enterobacteria_phage	6.2e-40	51.5
WP_106918304.1\|466531_466801_+	host cell division inhibitor Icd-like protein	A0A2H4JGW3	uncultured_Caudovirales_phage	2.4e-44	94.4
WP_001549752.1\|466793_466982_+	hypothetical protein	NA	NA	NA	NA
WP_004150967.1\|466974_467289_+	hypothetical protein	NA	NA	NA	NA
WP_004150966.1\|467285_467654_+	hypothetical protein	A0A2H4JCX7	uncultured_Caudovirales_phage	3.7e-51	81.1
WP_001549749.1\|467650_468016_+	hypothetical protein	NA	NA	NA	NA
WP_004150965.1\|468015_470151_+	DUF927 domain-containing protein	A0A1W6JPG0	Morganella_phage	3.4e-205	62.4
WP_004150964.1\|470493_470829_+	hypothetical protein	NA	NA	NA	NA
WP_004150963.1\|470877_471390_-	hypothetical protein	NA	NA	NA	NA
WP_001549743.1\|471653_472820_+\|capsid	phage major capsid protein	A0A2H4JED2	uncultured_Caudovirales_phage	9.8e-207	95.9
WP_001547826.1\|472871_473432_+\|head,protease	HK97 family phage prohead protease	A0A2H4JB68	uncultured_Caudovirales_phage	1.2e-98	95.7
WP_004150962.1\|473433_474675_+\|portal	phage portal protein	A0A2H4JFJ9	uncultured_Caudovirales_phage	1.0e-230	96.5
WP_004150961.1\|474671_475007_+\|head	phage head closure protein	A0A2H4JHK5	uncultured_Caudovirales_phage	3.7e-26	57.8
WP_001547824.1\|475003_475303_+\|head,tail	phage gp6-like head-tail connector protein	A0A2H4JD08	uncultured_Caudovirales_phage	3.4e-39	80.8
WP_004150959.1\|475302_475746_+	HNH endonuclease	A0A2H4JAS8	uncultured_Caudovirales_phage	2.8e-77	91.8
WP_004150957.1\|475738_475891_+	hypothetical protein	A0A2H4JCY9	uncultured_Caudovirales_phage	2.4e-17	88.0
WP_000113647.1\|476021_476378_+\|terminase	phage terminase small subunit P27 family	A0A2H4JHS3	uncultured_Caudovirales_phage	5.5e-60	99.2
WP_004150955.1\|476361_478023_+\|terminase	terminase large subunit	A0A2H4JB64	uncultured_Caudovirales_phage	0.0e+00	98.0
478368:478385	attR	NA	NA	NA	NA

DBSCAN-SWA_2

2009109 : 2065376

Microcystis_phage(27.27%)

plate,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_032425077.1\|2009109_2009856_+\|protease	proteasome-type protease	NA	NA	NA	NA
WP_032425076.1\|2010294_2011281_+	fatty acid desaturase	NA	NA	NA	NA
WP_004145488.1\|2012112_2012235_-	nitrilotriacetate monooxygenase	NA	NA	NA	NA
WP_004219597.1\|2012532_2012676_-	hypothetical protein	NA	NA	NA	NA
WP_023286625.1\|2012852_2013794_+	transcriptional regulator TdcA	NA	NA	NA	NA
WP_002910762.1\|2013887_2014877_+	bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB	NA	NA	NA	NA
WP_004145486.1\|2014902_2016234_+	threonine/serine transporter TdcC	NA	NA	NA	NA
WP_032425074.1\|2016261_2017470_+	propionate kinase	NA	NA	NA	NA
WP_032425474.1\|2017498_2019793_+	formate C-acetyltransferase	A0A2P0VNR5	Tetraselmis_virus	7.4e-158	41.7
WP_004225356.1\|2019844_2019991_-	hypothetical protein	NA	NA	NA	NA
WP_004189329.1\|2020280_2021339_+	branched-chain amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_004175489.1\|2021448_2022363_+	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_060614333.1\|2022372_2023659_+	high-affinity branched-chain amino acid ABC transporter permease LivM	NA	NA	NA	NA
WP_032425073.1\|2023655_2024531_+	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	9.5e-05	41.5
WP_004175491.1\|2024527_2025247_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.5e-11	26.0
WP_002910720.1\|2025252_2026146_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_004180410.1\|2026429_2028073_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	5.7e-136	50.4
WP_002910717.1\|2028122_2028599_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_020801827.1\|2028697_2029624_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_032425072.1\|2029927_2031223_+	MFS transporter	Q6JIH2	Burkholderia_virus	7.4e-62	36.8
WP_004145468.1\|2031234_2032044_+	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_020801945.1\|2032018_2032918_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_002910657.1\|2033027_2033510_-	cold shock domain-containing protein	NA	NA	NA	NA
WP_004197491.1\|2033700_2034399_+	RluA family pseudouridine synthase	A0A2H4UV25	Bodo_saltans_virus	2.6e-05	27.2
WP_002910652.1\|2034424_2034964_-	DUF2058 domain-containing protein	NA	NA	NA	NA
WP_002910650.1\|2035078_2035408_-	gamma-glutamylcyclotransferase	NA	NA	NA	NA
WP_004899025.1\|2035976_2037317_+\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_004184632.1\|2037313_2037967_+	DotU family type IV/VI secretion system protein	NA	NA	NA	NA
WP_032425071.1\|2037970_2039668_+	OmpA family protein	NA	NA	NA	NA
WP_032425070.1\|2040126_2042613_+	type VI secretion system tip protein VgrG	NA	NA	NA	NA
WP_032425069.1\|2042636_2043968_+	S-type pyocin domain-containing protein	NA	NA	NA	NA
WP_072198477.1\|2044012_2044981_-\|transposase	IS5 family transposase	A0A1B0VFY5	Salmonella_phage	2.9e-172	91.3
WP_032425068.1\|2045057_2045567_+	hypothetical protein	NA	NA	NA	NA
WP_002910591.1\|2045563_2046070_+	hypothetical protein	NA	NA	NA	NA
WP_002910589.1\|2046164_2046317_+	hypothetical protein	NA	NA	NA	NA
WP_032423970.1\|2046306_2046816_+	hypothetical protein	NA	NA	NA	NA
WP_032425067.1\|2047109_2048465_+	S-type pyocin domain-containing protein	NA	NA	NA	NA
WP_004200304.1\|2048465_2048975_+	hypothetical protein	NA	NA	NA	NA
WP_015958632.1\|2048971_2049478_+	hypothetical protein	NA	NA	NA	NA
WP_072198474.1\|2049939_2050968_+	hypothetical protein	NA	NA	NA	NA
WP_015958629.1\|2050991_2051297_+	hypothetical protein	NA	NA	NA	NA
WP_014343203.1\|2051318_2052212_+	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A075BSL8	Microcystis_phage	8.8e-14	28.8
WP_032410376.1\|2052257_2052374_+	hypothetical protein	NA	NA	NA	NA
WP_016946122.1\|2052395_2053289_+	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A075BSL8	Microcystis_phage	1.7e-12	27.3
WP_038435084.1\|2053314_2053443_+	hypothetical protein	NA	NA	NA	NA
WP_004184615.1\|2053464_2054358_+	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A075BSL8	Microcystis_phage	2.2e-12	27.1
WP_162487910.1\|2054653_2054887_+	SUMF1/EgtB/PvdO family nonheme iron enzyme	NA	NA	NA	NA
WP_014343198.1\|2054850_2055423_+	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A7H6	Microcystis_virus	3.9e-07	33.3
WP_072093174.1\|2056160_2056346_+	hypothetical protein	NA	NA	NA	NA
WP_002910497.1\|2056643_2056910_+	PAAR domain-containing protein	NA	NA	NA	NA
WP_064181763.1\|2058059_2061470_+	type VI secretion protein VasK	NA	NA	NA	NA
WP_004148784.1\|2061603_2063367_+\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_073511693.1\|2063396_2064413_+\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_004184604.1\|2064393_2064930_+	type VI secretion system lipoprotein TssJ	NA	NA	NA	NA
WP_004152261.1\|2064932_2065376_+\|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA

DBSCAN-SWA_3

2742703 : 2753590

Escherichia_phage(87.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004151613.1\|2742703_2745811_+	beta-galactosidase	L0N6M2	Herpes_simplex_virus	0.0e+00	59.6
WP_004151612.1\|2745865_2747131_+	MFS transporter	NA	NA	NA	NA
WP_001620097.1\|2747161_2748250_-	AAA family ATPase	A0A077SLJ9	Escherichia_phage	8.0e-211	100.0
WP_002904006.1\|2748336_2748597_-	hypothetical protein	A0A077SK33	Escherichia_phage	3.5e-40	97.7
WP_004176269.1\|2748894_2749755_+	class A broad-spectrum beta-lactamase SHV-11	A0A077SL40	Escherichia_phage	2.2e-155	99.3
WP_002210513.1\|2749775_2750537_-	DeoR/GlpR transcriptional regulator	A0A077SK06	Escherichia_phage	1.9e-134	100.0
WP_004151610.1\|2750797_2751700_+	NAD(P)-dependent oxidoreductase	A0A077SLF7	Escherichia_phage	7.7e-159	99.3
WP_004151609.1\|2751711_2752977_+	four-carbon acid sugar kinase family protein	A0A077SLJ7	Escherichia_phage	6.6e-233	99.5
WP_002210516.1\|2752969_2753590_+	aldolase	A0A077SK32	Escherichia_phage	8.0e-115	100.0

DBSCAN-SWA_4

2947631 : 3019128

uncultured_Caudovirales_phage(34.0%)

plate,holin,integrase,terminase

attL 3010241:3010255|attR 3016250:3016264

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002902268.1\|2947631_2948717_-\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_004151598.1\|2948680_2950435_-\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_004151599.1\|2952106_2955532_-	type VI secretion protein VasK	NA	NA	NA	NA
WP_002902254.1\|2955515_2956655_-	hypothetical protein	NA	NA	NA	NA
WP_002902252.1\|2956651_2956909_-	PAAR domain-containing protein	NA	NA	NA	NA
WP_004151601.1\|2956953_2959371_-	DUF2235 domain-containing protein	NA	NA	NA	NA
WP_002902180.1\|2959358_2959889_-	T6SS immunity phospholipase A1-binding lipoprotein Tli1-KP	NA	NA	NA	NA
WP_002902178.1\|2959956_2960487_-	T6SS immunity phospholipase A1-binding lipoprotein Tli1-KP	NA	NA	NA	NA
WP_002902176.1\|2960555_2961086_-	T6SS immunity phospholipase A1-binding lipoprotein Tli1-KP	NA	NA	NA	NA
WP_002902174.1\|2961153_2961684_-	T6SS immunity phospholipase A1-binding lipoprotein Tli1-KP	NA	NA	NA	NA
WP_002902172.1\|2961752_2962283_-	T6SS immunity phospholipase A1-binding lipoprotein Tli1-KP	NA	NA	NA	NA
WP_002902169.1\|2962346_2963126_-	DUF4123 domain-containing protein	NA	NA	NA	NA
WP_004228410.1\|2963126_2965496_-	type VI secretion system tip protein VgrG	A0A2H4JCD4	uncultured_Caudovirales_phage	9.1e-18	33.8
WP_065519287.1\|2965497_2968152_-	type VI secretion system ATPase TssH	K4FB40	Cronobacter_phage	2.5e-96	33.4
WP_002902160.1\|2968416_2968908_-	type VI secretion system effector Hcp	NA	NA	NA	NA
WP_004151602.1\|2968912_2970619_-	OmpA family protein	NA	NA	NA	NA
WP_004151603.1\|2970615_2971305_-	DotU family type IV/VI secretion system protein	NA	NA	NA	NA
WP_004218490.1\|2971301_2972645_-\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_002902148.1\|2972654_2974199_-	type VI secretion system contractile sheath large subunit	NA	NA	NA	NA
WP_002902144.1\|2974241_2974733_-	type VI secretion system contractile sheath small subunit	NA	NA	NA	NA
WP_002902136.1\|2975578_2975827_+	DinI-like family protein	S5MQI1	Escherichia_phage	1.4e-25	70.4
WP_002902133.1\|2976049_2976334_-	hypothetical protein	NA	NA	NA	NA
WP_002902131.1\|2976438_2976648_-	hypothetical protein	NA	NA	NA	NA
WP_002902128.1\|2976644_2977376_-	hypothetical protein	NA	NA	NA	NA
WP_004218487.1\|2977386_2978115_-	hypothetical protein	NA	NA	NA	NA
WP_004152577.1\|2980465_2980663_-	hypothetical protein	NA	NA	NA	NA
WP_004152576.1\|2980662_2981529_-	hypothetical protein	A0A2H4IYR0	uncultured_Caudovirales_phage	1.9e-34	64.5
WP_004152575.1\|2981528_2982302_-	DUF2612 domain-containing protein	A0A2H4J1A9	uncultured_Caudovirales_phage	2.8e-77	54.4
WP_004152574.1\|2982298_2983495_-\|plate	baseplate J/gp47 family protein	A0A0M4RD32	Salmonella_phage	3.9e-158	72.9
WP_004152573.1\|2983494_2983848_-	hypothetical protein	A0A2H4J629	uncultured_Caudovirales_phage	2.3e-50	80.3
WP_004152572.1\|2983849_2984503_-	hypothetical protein	A0A2H4J8H6	uncultured_Caudovirales_phage	1.0e-59	63.5
WP_004152571.1\|2984556_2985123_-	hypothetical protein	NA	NA	NA	NA
WP_004199301.1\|2985165_2985348_-	hypothetical protein	NA	NA	NA	NA
WP_004152570.1\|2985397_2985739_-	hypothetical protein	A0A2H4J1A5	uncultured_Caudovirales_phage	1.8e-23	46.6
WP_004152569.1\|2985738_2986761_-	hypothetical protein	A0A2H4J1B2	uncultured_Caudovirales_phage	9.2e-100	54.2
WP_004217362.1\|2986763_2986991_-	hypothetical protein	A0A2H4J495	uncultured_Caudovirales_phage	4.6e-20	56.0
WP_004152567.1\|2987066_2987666_-	hypothetical protein	A0A2H4J1B3	uncultured_Caudovirales_phage	9.9e-54	57.6
WP_004152566.1\|2987665_2989669_-	lytic transglycosylase domain-containing protein	A0A2H4J9N7	uncultured_Caudovirales_phage	1.2e-247	63.6
WP_004152565.1\|2989658_2989811_-	hypothetical protein	A0A2H4J1A2	uncultured_Caudovirales_phage	7.6e-19	88.0
WP_004152564.1\|2989846_2990272_-	hypothetical protein	A0A2H4J2V6	uncultured_Caudovirales_phage	2.6e-40	63.4
WP_004199809.1\|2990275_2990716_-	DUF3277 family protein	A0A0M5M1K6	Salmonella_phage	3.3e-62	80.1
WP_004152177.1\|2990726_2991872_-	DUF3383 domain-containing protein	A0A2H4J8G4	uncultured_Caudovirales_phage	6.3e-166	76.9
WP_004152176.1\|2991875_2992316_-	hypothetical protein	A0A2H4J1A0	uncultured_Caudovirales_phage	1.6e-40	51.7
WP_001116156.1\|2992410_2992797_-	hypothetical protein	A0A2H4J1A4	uncultured_Caudovirales_phage	1.1e-48	78.2
WP_000834982.1\|2992796_2993303_-	hypothetical protein	NA	NA	NA	NA
WP_000113538.1\|2993299_2993719_-	DUF4054 domain-containing protein	A0A0M5M3S2	Salmonella_phage	3.3e-40	60.7
WP_000725700.1\|2993687_2993969_-	hypothetical protein	NA	NA	NA	NA
WP_001132269.1\|2994008_2994950_-	DUF2184 domain-containing protein	A0A2H4J191	uncultured_Caudovirales_phage	1.7e-137	77.1
WP_000528476.1\|2994961_2995456_-	hypothetical protein	A0A2H4JHM9	uncultured_Caudovirales_phage	4.2e-50	62.7
WP_004199270.1\|2995459_2996662_-	DUF2213 domain-containing protein	A0A0M4R5A6	Salmonella_phage	2.6e-106	54.1
WP_004152174.1\|2996713_2997262_-	hypothetical protein	A0A0M4REK0	Salmonella_phage	3.0e-49	56.3
WP_004152173.1\|2997317_2998769_-	DUF1073 domain-containing protein	A0A0M4S6U1	Salmonella_phage	3.8e-192	68.8
WP_004152172.1\|2999006_3000407_-\|terminase	PBSX family phage terminase large subunit	A0A077KAW0	Edwardsiella_phage	9.4e-188	69.0
WP_004218030.1\|3000357_3000846_-	hypothetical protein	NA	NA	NA	NA
WP_004152170.1\|3001211_3001532_-	hypothetical protein	NA	NA	NA	NA
WP_004153952.1\|3001766_3002156_-	lipase chaperone	A0A192Y6H8	Salmonella_phage	9.4e-21	49.2
WP_004152169.1\|3002152_3002683_-	lysozyme	K7PLY1	Enterobacteria_phage	2.7e-79	77.1
WP_004146526.1\|3002685_3002934_-\|holin	class II holin family protein	NA	NA	NA	NA
WP_004152167.1\|3003339_3004122_-	antitermination protein	F1C595	Cronobacter_phage	7.2e-113	76.8
WP_004198239.1\|3004118_3004595_-	hypothetical protein	A0A286N2Q1	Klebsiella_phage	1.8e-90	100.0
WP_004198233.1\|3004591_3005554_-	toprim domain-containing protein	A0A286N2Q0	Klebsiella_phage	4.8e-183	99.4
WP_004198228.1\|3005555_3007214_-	DEAD/DEAH box helicase	A0A286N2P9	Klebsiella_phage	0.0e+00	96.0
WP_004152162.1\|3007790_3008012_-	helix-turn-helix transcriptional regulator	A0A286S2C1	Klebsiella_phage	3.0e-32	100.0
WP_004152161.1\|3008109_3008778_+	LexA family transcriptional regulator	A0A286S2B2	Klebsiella_phage	2.4e-125	99.5
WP_004152160.1\|3008948_3009263_+	hypothetical protein	A0A286S1T9	Klebsiella_phage	1.0e-49	100.0
WP_004152159.1\|3009255_3009444_+	hypothetical protein	A0A286S1P8	Klebsiella_phage	4.6e-26	100.0
WP_004152158.1\|3009613_3009979_+	hypothetical protein	A0A286S1Q6	Klebsiella_phage	6.9e-58	99.2
WP_004152157.1\|3009971_3010226_+	hypothetical protein	A0A286SGR4	Klebsiella_phage	3.1e-41	97.6
WP_004177208.1\|3010197_3010416_+	hypothetical protein	A0A286S1P6	Klebsiella_phage	6.6e-32	98.6
3010241:3010255	attL	NA	NA	NA	NA
WP_004152156.1\|3010412_3010838_+	hypothetical protein	A0A286S1S2	Klebsiella_phage	3.5e-53	77.9
WP_004152155.1\|3010834_3011029_+	hypothetical protein	NA	NA	NA	NA
WP_004152154.1\|3011025_3011853_+	hypothetical protein	Q8W654	Enterobacteria_phage	5.5e-111	84.0
WP_004152153.1\|3011957_3012476_+	hypothetical protein	A0A286S1S7	Klebsiella_phage	1.7e-94	98.8
WP_004154298.1\|3012481_3013192_+	Rha family transcriptional regulator	A0A286S260	Klebsiella_phage	2.1e-111	88.3
WP_004152151.1\|3013181_3013406_+	hypothetical protein	A0A286S2B3	Klebsiella_phage	3.1e-29	89.2
WP_004152150.1\|3013402_3013615_+	hypothetical protein	A0A286S2B6	Klebsiella_phage	3.4e-33	98.6
WP_014343018.1\|3013857_3014091_+	hypothetical protein	NA	NA	NA	NA
WP_004198245.1\|3014163_3014310_+	hypothetical protein	A0A1B5FPC2	Escherichia_phage	2.9e-15	70.8
WP_004152148.1\|3014269_3014512_+	hypothetical protein	A0A0M4RTZ2	Salmonella_phage	2.2e-20	73.8
WP_004152147.1\|3014492_3015674_-\|integrase	site-specific integrase	A0A0M4QX09	Salmonella_phage	5.6e-202	84.2
WP_016197745.1\|3015870_3016419_+	DJ-1/PfpI family protein	NA	NA	NA	NA
3016250:3016264	attR	NA	NA	NA	NA
WP_004152145.1\|3016617_3018150_-	HD domain-containing protein	A0A1B1ISR1	uncultured_Mediterranean_phage	1.1e-21	30.0
WP_004152144.1\|3018366_3019128_-	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	2.4e-20	32.5

DBSCAN-SWA_5

3443505 : 3452969

Brazilian_cedratvirus(16.67%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004150847.1\|3443505_3445227_+	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	A0A2R8FG22	Brazilian_cedratvirus	1.5e-14	34.3
WP_002898014.1\|3445271_3445973_+\|tRNA	leucyl/phenylalanyl-tRNA--protein transferase	NA	NA	NA	NA
WP_001040187.1\|3446326_3446545_+	translation initiation factor IF-1	NA	NA	NA	NA
WP_002896522.1\|3446665_3448945_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	1.6e-165	42.0
WP_002896520.1\|3448975_3449293_-\|protease	ATP-dependent Clp protease adapter ClpS	A0A1B1IT64	uncultured_Mediterranean_phage	2.0e-13	45.7
WP_002896516.1\|3449618_3449840_+	cold shock-like protein CspD	A0A2H4N7Y6	Lake_Baikal_phage	1.3e-16	61.2
WP_004150848.1\|3449916_3451857_-	macrolide ABC transporter ATP-binding protein/permease MacB	G9BWD6	Planktothrix_phage	1.9e-37	40.5
WP_065874941.1\|3451853_3452969_-	macrolide transporter subunit MacA	A0A140XAI1	Dickeya_phage	1.3e-06	52.7

DBSCAN-SWA_6

3933107 : 3978380

Cronobacter_phage(25.0%)

holin,lysis,head,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004151249.1\|3933107_3935585_-	MoaD/ThiS family protein	F1C5A7	Cronobacter_phage	2.7e-198	45.6
WP_004151250.1\|3935571_3935967_-	C40 family peptidase	F1C5F2	Cronobacter_phage	8.0e-36	54.0
WP_004199076.1\|3935963_3936434_-	hypothetical protein	R9TPR6	Aeromonas_phage	2.5e-28	41.0
WP_004151252.1\|3936433_3936910_-	hypothetical protein	A0A2P1MXB5	Escherichia_phage	3.0e-37	49.7
WP_004151253.1\|3936952_3940399_-	tape measure protein	Q5G8W8	Enterobacteria_phage	1.4e-163	48.6
WP_004151254.1\|3940491_3940995_-	hypothetical protein	NA	NA	NA	NA
WP_004151255.1\|3941122_3941908_-	phage repressor protein	A0A2L1IV39	Escherichia_phage	1.9e-84	59.7
WP_004151256.1\|3941973_3942687_-	hypothetical protein	H6WRU8	Salmonella_phage	3.9e-49	50.2
WP_004151257.1\|3942676_3942847_-	Arc family DNA-binding protein	I6R9A8	Salmonella_phage	6.1e-17	87.0
WP_004151258.1\|3942946_3943306_+	Arc family DNA-binding protein	A0A0P0ZBD1	Stx2-converting_phage	3.8e-16	47.5
WP_004151259.1\|3943322_3943793_-	hypothetical protein	NA	NA	NA	NA
WP_004151260.1\|3944086_3944341_-	hypothetical protein	K7PM89	Enterobacteria_phage	6.7e-20	73.0
WP_004151261.1\|3944343_3945099_-	KilA-N domain-containing protein	K7PGT4	Enterobacteria_phage	2.4e-60	51.0
WP_004151262.1\|3945274_3945952_-	hypothetical protein	F1C5E8	Cronobacter_phage	4.8e-73	57.9
WP_004151263.1\|3946004_3946757_-	Ig domain-containing protein	G0ZNE6	Cronobacter_phage	5.8e-43	42.1
WP_004151264.1\|3946825_3947218_-	hypothetical protein	G0ZNE4	Cronobacter_phage	5.1e-35	52.7
WP_004151265.1\|3947214_3947640_-	hypothetical protein	R9TPP7	Aeromonas_phage	5.1e-28	47.9
WP_004151266.1\|3947642_3948005_-	hypothetical protein	A0A173GCE0	Salmonella_phage	1.8e-18	45.0
WP_004151267.1\|3948004_3948178_-	hypothetical protein	I6R0P9	Salmonella_phage	1.4e-13	56.1
WP_004151268.1\|3948177_3948558_-	hypothetical protein	F1C5E2	Cronobacter_phage	5.3e-29	55.3
WP_004151269.1\|3948560_3948800_-	hypothetical protein	NA	NA	NA	NA
WP_004151270.1\|3948810_3949905_-	hypothetical protein	F1C5E1	Cronobacter_phage	1.7e-123	62.8
WP_004151271.1\|3949916_3950345_-	hypothetical protein	F1C5E0	Cronobacter_phage	1.6e-42	60.8
WP_004151272.1\|3950348_3951734_-	DUF2213 domain-containing protein	F1C5D9	Cronobacter_phage	2.3e-154	60.0
WP_004151273.1\|3951806_3952283_-	hypothetical protein	NA	NA	NA	NA
WP_004151274.1\|3952324_3953329_-\|head	phage head morphogenesis protein	F1C5D8	Cronobacter_phage	9.0e-116	69.7
WP_004151275.1\|3953303_3954725_-	DUF1073 domain-containing protein	F1C5D7	Cronobacter_phage	9.6e-148	57.1
WP_004151276.1\|3954737_3956210_-	hypothetical protein	A0A1W6JNY3	Morganella_phage	1.3e-248	82.5
WP_004151277.1\|3956209_3956812_-	hypothetical protein	G8C7P2	Escherichia_phage	5.4e-76	80.9
WP_004151279.1\|3957182_3957512_+	hypothetical protein	NA	NA	NA	NA
WP_004151280.1\|3957617_3958082_-\|lysis	lysis protein	Q76H63	Enterobacteria_phage	2.4e-55	73.2
WP_004151281.1\|3958078_3958609_-	lysozyme	G9L6J6	Escherichia_phage	6.0e-79	78.5
WP_004151282.1\|3958611_3958860_-\|holin	class II holin family protein	NA	NA	NA	NA
WP_004151283.1\|3959769_3960459_-	antitermination protein	I6PDF8	Cronobacter_phage	1.4e-56	54.5
WP_004151284.1\|3960455_3960986_-	HNH endonuclease	A0A193GYW9	Enterobacter_phage	5.2e-30	43.1
WP_004151285.1\|3960978_3961116_-	YlcG family protein	NA	NA	NA	NA
WP_004151286.1\|3961112_3961748_-	recombination protein NinG	M9NYX8	Enterobacteria_phage	2.7e-81	77.9
WP_004151287.1\|3961740_3961911_-	NinE family protein	G8C7V4	Escherichia_phage	1.3e-14	73.2
WP_004151288.1\|3961910_3962366_-	hypothetical protein	K7P7B8	Enterobacteria_phage	8.0e-56	69.5
WP_004151291.1\|3962866_3963514_-	DUF551 domain-containing protein	A5LH60	Enterobacteria_phage	4.5e-12	32.6
WP_004151292.1\|3963510_3963687_-	hypothetical protein	NA	NA	NA	NA
WP_004151293.1\|3963686_3964529_-	ead/Ea22-like family protein	A0A2H4FRZ0	Salmonella_phage	1.8e-29	60.8
WP_004151294.1\|3964635_3965142_-	hypothetical protein	A0A0A6Z565	Enterobacter_phage	3.0e-27	59.6
WP_004151295.1\|3965138_3965432_-	protein ren	O48423	Enterobacteria_phage	3.3e-26	65.6
WP_004230547.1\|3965431_3966847_-	AAA family ATPase	Q9MCT4	Escherichia_phage	1.8e-183	67.1
WP_004230546.1\|3966851_3967703_-	hypothetical protein	F1C5C3	Cronobacter_phage	5.3e-85	56.3
WP_004151298.1\|3967743_3967890_-	hypothetical protein	NA	NA	NA	NA
WP_001548453.1\|3967975_3968197_-	hypothetical protein	G8EYH8	Enterobacteria_phage	6.9e-05	41.7
WP_004151299.1\|3968237_3968471_-	helix-turn-helix domain-containing protein	G8C7U2	Escherichia_phage	4.3e-13	50.7
WP_004151300.1\|3968598_3969288_+	helix-turn-helix transcriptional regulator	G8C7U1	Escherichia_phage	4.3e-61	52.2
WP_004151301.1\|3969638_3969854_+	hypothetical protein	B5WZV1	Pseudomonas_phage	1.6e-09	48.6
WP_004151302.1\|3969850_3969961_+	hypothetical protein	NA	NA	NA	NA
WP_004151303.1\|3969953_3970148_+	hypothetical protein	NA	NA	NA	NA
WP_004151304.1\|3970236_3970521_+	host nuclease inhibitor GamL	G8C7T1	Escherichia_phage	8.0e-30	62.8
WP_004151305.1\|3970536_3971382_+	phage recombination protein Bet	A0A1I9KF88	Aeromonas_phage	6.9e-69	59.2
WP_004151306.1\|3971378_3972059_+	YqaJ viral recombinase family protein	A0A0M3ULE0	Salmonella_phage	7.9e-124	93.4
WP_004151308.1\|3972055_3972214_+	DUF1317 family protein	A0A0N7CHV0	Escherichia_phage	3.0e-10	60.8
WP_004151310.1\|3972210_3972867_+	DNA methyltransferase	G8C7S6	Escherichia_phage	2.7e-113	87.5
WP_004151312.1\|3972863_3973631_+	hypothetical protein	D5LH17	Escherichia_phage	1.7e-66	53.4
WP_004151314.1\|3973627_3973846_+	hypothetical protein	A0A1I9LJM7	Stx_converting_phage	1.2e-09	47.2
WP_004151316.1\|3973847_3974063_+	TraR/DksA family transcriptional regulator	A0A0K2FI84	Escherichia_phage	4.0e-13	52.9
WP_004151317.1\|3974064_3974400_+	excisionase family DNA-binding protein	NA	NA	NA	NA
WP_004143017.1\|3975868_3976735_+	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	1.3e-30	34.8
WP_004143016.1\|3976736_3976949_+	ribosome-associated protein YbcJ	NA	NA	NA	NA
WP_004143010.1\|3976994_3978380_-\|tRNA	cysteine--tRNA ligase	M1PG92	Moumouvirus	3.5e-46	35.4

DBSCAN-SWA_7

4189241 : 4200895

Enterobacteria_phage(70.0%)

integrase

attL 4189691:4189705|attR 4212748:4212762

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004144574.1\|4189241_4190345_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	4.8e-62	40.5
4189691:4189705	attL	NA	NA	NA	NA
WP_002889940.1\|4190355_4191609_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	8.9e-89	44.9
WP_002889938.1\|4191961_4193152_+\|integrase	tyrosine-type recombinase/integrase	Q7M297	Enterobacteria_phage	6.4e-145	62.7
WP_004152029.1\|4193139_4194090_+	AAA family ATPase	A0A1X9IGI7	Lactococcus_phage	1.2e-13	27.1
WP_004152979.1\|4194089_4194515_+	hypothetical protein	NA	NA	NA	NA
WP_002889930.1\|4195083_4195650_-	phage polarity suppression protein	Q7M2A1	Enterobacteria_phage	1.5e-59	64.3
WP_002889919.1\|4195667_4195913_-	ogr/Delta-like zinc finger family protein	Q7M294	Enterobacteria_phage	1.9e-19	58.0
WP_002889917.1\|4195909_4196647_-	hypothetical protein	Q7M2A2	Enterobacteria_phage	9.0e-73	60.7
WP_002889915.1\|4197188_4197455_+	AlpA family transcriptional regulator	Q7M299	Enterobacteria_phage	2.6e-30	71.6
WP_024940872.1\|4197451_4198009_+	ash family protein	Q7M2A7	Enterobacteria_phage	1.8e-33	70.4
WP_002889911.1\|4198005_4198233_+	hypothetical protein	NA	NA	NA	NA
WP_002889897.1\|4198229_4198550_+	DUF5375 domain-containing protein	NA	NA	NA	NA
WP_002889890.1\|4198561_4200895_+	toprim domain-containing protein	Q7M2A8	Enterobacteria_phage	0.0e+00	82.2
4212748:4212762	attR	NA	NA	NA	NA

DBSCAN-SWA_8

4669139 : 4674964

Enterobacteria_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004152207.1\|4669139_4671473_-	toprim domain-containing protein	Q7M2A8	Enterobacteria_phage	0.0e+00	83.9
WP_004152206.1\|4671487_4671808_-	DUF5375 domain-containing protein	NA	NA	NA	NA
WP_004152205.1\|4671804_4672032_-	hypothetical protein	NA	NA	NA	NA
WP_004153681.1\|4672028_4672577_-	host cell division inhibitor Icd-like protein	Q7M2A7	Enterobacteria_phage	1.1e-30	69.4
WP_000556592.1\|4672573_4672840_-	AlpA family transcriptional regulator	Q7M299	Enterobacteria_phage	2.0e-30	71.6
WP_004152204.1\|4673400_4674138_+	hypothetical protein	Q7M2A2	Enterobacteria_phage	1.1e-70	59.4
WP_004152203.1\|4674134_4674380_+	ogr/Delta-like zinc finger family protein	Q7M294	Enterobacteria_phage	5.5e-19	56.8
WP_004152202.1\|4674397_4674964_+	phage polarity suppression protein	Q7M2A1	Enterobacteria_phage	9.7e-59	63.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP018441

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 1382

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001572351.1\|701_1382_-	copper/silver response regulator transcription factor SilR	W8CYM9	Bacillus_phage	2.1e-31	35.6

DBSCAN-SWA_2

4755 : 105585

Escherichia_phage(34.38%)

protease,transposase,bacteriocin,integrase

attL 59821:59880|attR 78629:79450

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004098958.1\|4755_7902_+	Cu(+)/Ag(+) efflux RND transporter permease subunit SilA	S5VTK5	Leptospira_phage	4.0e-61	22.5
WP_000758228.1\|7988_8429_+	hypothetical protein	NA	NA	NA	NA
WP_004098955.1\|8555_11003_+	Ag(+)-translocating P-type ATPase SilP	A0A218MNH6	uncultured_virus	7.6e-84	35.8
WP_000843497.1\|11043_11241_+	DUF2933 domain-containing protein	NA	NA	NA	NA
WP_004118669.1\|11274_12012_-	peptidoglycan DD-metalloendopeptidase family protein	A0A2H4JAF5	uncultured_Caudovirales_phage	1.2e-11	32.5
WP_001023257.1\|12300_12750_-	copper resistance protein	NA	NA	NA	NA
WP_000019473.1\|13038_14019_-\|transposase	IS5-like element ISKpn26 family transposase	Q38213	Escherichia_phage	8.9e-185	99.1
WP_000925242.1\|14183_16001_+	multicopper oxidase PcoA	NA	NA	NA	NA
WP_001378118.1\|16006_16897_+	copper resistance outer membrane transporter PcoB	NA	NA	NA	NA
WP_000025662.1\|16936_17317_+	copper resistance system metallochaperone PcoC	NA	NA	NA	NA
WP_004118344.1\|17321_18251_+	copper resistance inner membrane protein PcoD	NA	NA	NA	NA
WP_001188930.1\|18305_18986_+	copper response regulator transcription factor PcoR	W8CYM9	Bacillus_phage	8.7e-30	34.4
WP_004152084.1\|18982_20383_+	copper resistance membrane spanning protein PcoS	W8CYF6	Bacillus_phage	4.1e-18	26.3
WP_004152085.1\|20599_21034_+	copper resistance system metallochaperone PcoE	NA	NA	NA	NA
WP_004152086.1\|21265_21445_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_031944101.1\|23187_23697_+	aquaporin	NA	NA	NA	NA
WP_004152091.1\|23746_24244_-	N-acetyltransferase	NA	NA	NA	NA
WP_004152092.1\|24575_24902_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_004152093.1\|24898_25612_+	arsenical resistance protein ArsH	A0A2H4J5V6	uncultured_Caudovirales_phage	2.9e-92	77.0
WP_004182005.1\|25620_26166_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_004152095.1\|26241_26604_+	arsenic metallochaperone ArsD family protein	NA	NA	NA	NA
WP_004152096.1\|28500_29037_+	N-acetyltransferase	NA	NA	NA	NA
WP_004152097.1\|29069_29495_-	glutaredoxin-dependent arsenate reductase	A0A2H4J8T1	uncultured_Caudovirales_phage	2.3e-52	72.9
WP_004152098.1\|29507_30797_-	arsenite efflux transporter membrane subunit ArsB	A0A2H4J144	uncultured_Caudovirales_phage	1.9e-171	74.0
WP_004152099.1\|30844_32596_-	arsenite efflux transporter ATPase subunit ArsA	NA	NA	NA	NA
WP_004152100.1\|32613_32976_-	arsenite efflux transporter metallochaperone ArsD	NA	NA	NA	NA
WP_004152101.1\|33025_33376_-	As(III)-sensing metalloregulatory transcriptional repressor ArsR	A0A2H4J145	uncultured_Caudovirales_phage	1.4e-23	50.9
WP_004152102.1\|33733_34003_+	hypothetical protein	NA	NA	NA	NA
WP_004152103.1\|33990_34566_+	hypothetical protein	NA	NA	NA	NA
WP_004152104.1\|34596_35091_+	DNA-binding protein	NA	NA	NA	NA
WP_004152105.1\|35134_35503_+	hypothetical protein	NA	NA	NA	NA
WP_004152106.1\|35536_35740_+	hemolysin expression modulator Hha	NA	NA	NA	NA
WP_004152107.1\|35788_36046_+	hypothetical protein	NA	NA	NA	NA
WP_004152108.1\|36121_36376_+	hypothetical protein	NA	NA	NA	NA
WP_003026799.1\|36551_36818_+	DUF1778 domain-containing protein	NA	NA	NA	NA
WP_003026803.1\|36805_37288_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_020314316.1\|37499_38846_+\|transposase	ISNCY family transposase	NA	NA	NA	NA
WP_004152113.1\|40688_41651_-\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_009483782.1\|41637_42387_-	phosphate-starvation-inducible PsiE family protein	NA	NA	NA	NA
WP_004152115.1\|42624_42822_-	hypothetical protein	NA	NA	NA	NA
WP_004152116.1\|42821_45617_-	heat shock survival AAA family ATPase ClpK	K4FB40	Cronobacter_phage	5.2e-129	41.0
WP_004152117.1\|45731_46301_-	small heat shock protein sHSP20	NA	NA	NA	NA
WP_004152118.1\|46335_46617_-	helix-turn-helix domain-containing protein	A0A1B1IUF9	uncultured_Mediterranean_phage	5.2e-05	38.2
WP_004118208.1\|46860_47124_-	hypothetical protein	NA	NA	NA	NA
WP_004118209.1\|47138_47402_+\|transposase	transposase	NA	NA	NA	NA
WP_000019473.1\|48603_49584_+\|transposase	IS5-like element ISKpn26 family transposase	Q38213	Escherichia_phage	8.9e-185	99.1
WP_004152692.1\|50792_51662_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_004152693.1\|51655_52666_-	phosphonate dehydrogenase PtxD	A0A1V0SBV6	Catovirus	1.4e-15	25.1
WP_004152694.1\|52674_53502_-	phosphonate ABC transporter, permease protein PhnE	NA	NA	NA	NA
WP_004152695.1\|53510_54374_-	phosphate/phosphite/phosphonate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_004153729.1\|54370_55198_-	phosphonate ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.6e-20	37.6
WP_004217321.1\|56053_56758_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.2e-138	99.6
WP_044117068.1\|58061_58730_+\|transposase	IS6 family transposase	A0A077SL39	Escherichia_phage	1.9e-130	99.5
WP_000018329.1\|58919_59735_-	aminoglycoside O-phosphotransferase APH(3')-Ia	A0A193DTG4	Autographa_californica_nuclear_polyhedrosis_virus	6.1e-163	100.0
59821:59880	attL	NA	NA	NA	NA
WP_001067855.1\|59885_60590_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_004201280.1\|60825_61299_-	trimethoprim-resistant dihydrofolate reductase DfrA14	G3MBI7	Bacillus_virus	8.4e-16	28.9
WP_073545622.1\|61454_62414_+\|integrase	class 1 integron integrase IntI1	A0A1P8DJJ6	Virus_Rctr41k	1.1e-67	44.6
WP_001067855.1\|62447_63152_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_001144737.1\|63260_63527_+	plasmid mobilization relaxosome protein MobC	NA	NA	NA	NA
WP_001389365.1\|63669_64434_+\|transposase	IS6-like element IS6100 family transposase	A0A077SL39	Escherichia_phage	4.3e-86	65.7
WP_004098817.1\|64694_65909_+	type II site-specific deoxyribonuclease	E5E3X4	Burkholderia_phage	1.2e-34	42.5
WP_072094655.1\|65942_67346_-	DNA cytosine methyltransferase	E5E3X6	Burkholderia_phage	9.0e-106	50.6
WP_001749967.1\|67757_67964_-	hypothetical protein	NA	NA	NA	NA
WP_001749966.1\|67968_68610_-	restriction endonuclease	NA	NA	NA	NA
WP_001452736.1\|68665_68977_-	hypothetical protein	NA	NA	NA	NA
WP_001749965.1\|69012_69327_-	KikA protein	NA	NA	NA	NA
WP_073545624.1\|69323_69668_-	hypothetical protein	NA	NA	NA	NA
WP_024129965.1\|69683_70034_-	H-NS histone family protein	NA	NA	NA	NA
WP_001749963.1\|70097_70832_+	lytic transglycosylase domain-containing protein	NA	NA	NA	NA
WP_000440698.1\|70840_71122_+	hypothetical protein	NA	NA	NA	NA
WP_001749962.1\|71131_71425_+	hypothetical protein	NA	NA	NA	NA
WP_000496058.1\|71474_71792_+	VirB3 family type IV secretion system protein	NA	NA	NA	NA
WP_001067858.1\|74103_74808_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.2e-138	99.6
WP_000239590.1\|75117_75993_+	class A extended-spectrum beta-lactamase CTX-M-15	A0A1B0VBP7	Salmonella_phage	1.1e-125	82.4
WP_001393253.1\|76039_76372_-	cupin fold metalloprotein, WbuC family	NA	NA	NA	NA
WP_001067855.1\|78693_79398_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_002063889.1\|80591_81134_-	AAA family ATPase	NA	NA	NA	NA
78629:79450	attR	NA	NA	NA	NA
WP_000557452.1\|81146_82007_-	aminoglycoside N-acetyltransferase AAC(3)-IIe	NA	NA	NA	NA
WP_001067855.1\|82113_82818_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_001334766.1\|83449_84280_-	oxacillin-hydrolyzing class D beta-lactamase OXA-1	NA	NA	NA	NA
WP_063840321.1\|84410_84965_-	fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr5	NA	NA	NA	NA
WP_001067855.1\|85108_85813_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_004152290.1\|90189_92499_+	TerB N-terminal domain-containing protein	NA	NA	NA	NA
WP_004152291.1\|92502_93819_+	ATP-binding protein	NA	NA	NA	NA
WP_000093087.1\|93815_96011_+	DEAD/DEAH box helicase	NA	NA	NA	NA
WP_004152292.1\|97457_98315_-	incFII family plasmid replication initiator RepA	NA	NA	NA	NA
WP_004171457.1\|98307_98385_-	RepA leader peptide Tap	NA	NA	NA	NA
WP_004199332.1\|98601_98880_-	replication regulatory protein RepA	NA	NA	NA	NA
WP_009485932.1\|99200_99680_-	phospholipase D family protein	A0A1B2LRT6	Wolbachia_phage	9.8e-20	35.2
WP_004152296.1\|100020_100299_-\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_004178051.1\|100300_102622_-\|bacteriocin	klebicin B-related nuclease bacteriocin	NA	NA	NA	NA
WP_004178052.1\|102978_103524_+	hypothetical protein	NA	NA	NA	NA
WP_004152301.1\|103738_104086_-	hypothetical protein	NA	NA	NA	NA
WP_004178053.1\|104105_104702_-	fertility inhibition protein FinO	NA	NA	NA	NA
WP_004152303.1\|104859_105585_-	type-F conjugative transfer system pilin acetylase TraX	A0A1D6ZIU7	Xanthomonas_phage	5.5e-06	29.4

DBSCAN-SWA_3

131359 : 137542

Salmonella_phage(20.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_072198477.1\|131359_132328_+\|transposase	IS5 family transposase	A0A1B0VFY5	Salmonella_phage	2.9e-172	91.3
WP_004178063.1\|133059_133545_+	transglycosylase SLT domain-containing protein	NA	NA	NA	NA
WP_011977736.1\|133577_133907_-	hypothetical protein	NA	NA	NA	NA
WP_004178064.1\|133939_134761_-	DUF945 domain-containing protein	K4F5L3	Cronobacter_phage	2.6e-44	40.4
WP_004152722.1\|135594_136008_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_004152721.1\|136008_136287_-	helix-turn-helix transcriptional regulator	O64356	Escherichia_phage	2.5e-07	39.4
WP_004152720.1\|136276_136597_-	type II toxin-antitoxin system RelE/ParE family toxin	A0A088CBP5	Shigella_phage	6.8e-09	39.5
WP_004152719.1\|136677_136902_-	hypothetical protein	NA	NA	NA	NA
WP_004152718.1\|136912_137125_-	hypothetical protein	NA	NA	NA	NA
WP_004152717.1\|137185_137542_-	hypothetical protein	A0A248SL90	Klebsiella_phage	2.6e-25	58.1

DBSCAN-SWA_4

142962 : 147247

Emiliania_huxleyi_virus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004178066.1\|142962_144999_-	ParB/RepB/Spo0J family partition protein	G8DH78	Emiliania_huxleyi_virus	9.0e-22	26.0
WP_004152643.1\|145068_145317_-	DUF905 domain-containing protein	NA	NA	NA	NA
WP_004152644.1\|145365_145908_-	single-stranded DNA-binding protein	A0A0A0P1Q9	Enterobacteria_phage	6.0e-50	76.7
WP_004152645.1\|146683_147247_-	methyltransferase	A8HNV9	Thalassomonas_phage	1.3e-18	34.1

DBSCAN-SWA_5

150384 : 167597

Macacine_betaherpesvirus(30.0%)

transposase,integrase

attL 146771:146787|attR 177832:177848

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
146771:146787	attL	NA	NA	NA	NA
WP_004152754.1\|150384_150639_-	DNA polymerase III subunit theta	H9C187	Pectobacterium_phage	1.2e-11	50.0
WP_004118478.1\|150875_151301_-	antirestriction protein	NA	NA	NA	NA
WP_004152753.1\|151821_152052_-	hypothetical protein	NA	NA	NA	NA
WP_004178082.1\|152285_153773_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	1.2e-31	35.5
WP_004178083.1\|154175_154601_+	translesion error-prone DNA polymerase V autoproteolytic subunit	A0A1W6JNS2	Morganella_phage	8.3e-31	49.6
WP_004152715.1\|154600_155872_+	Y-family DNA polymerase	F1C5A5	Cronobacter_phage	5.6e-155	63.7
WP_004152062.1\|158823_159795_-	ParB/RepB/Spo0J family plasmid partition protein	I3WF22	Macacine_betaherpesvirus	4.1e-150	86.6
WP_000523813.1\|159794_160961_-	plasmid-partitioning protein SopA	A0A2I6B2X3	Macacine_betaherpesvirus	1.4e-224	97.7
WP_004152063.1\|161712_162723_+	replication initiation protein	J9Q7H0	Salmonella_phage	8.8e-87	55.9
WP_001515717.1\|163439_164180_-\|integrase	site-specific integrase	I3WFA4	Macacine_betaherpesvirus	5.4e-25	58.6
WP_004152065.1\|165323_166271_+	sensor domain-containing diguanylate cyclase	G3MA91	Bacillus_virus	1.8e-12	30.6
WP_071527918.1\|166297_166609_-	EAL domain-containing protein	NA	NA	NA	NA
WP_011977741.1\|166628_167597_+\|transposase	IS5 family transposase	A0A1B0VFY5	Salmonella_phage	2.5e-184	98.1
177832:177848	attR	NA	NA	NA	NA

DBSCAN-SWA_6

172905 : 177150

Vibrio_phage(50.0%)

holin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004178088.1\|172905_174903_-\|holin	choline BCCT transporter BetT	A0A2I7QNT1	Vibrio_phage	9.7e-21	25.9
WP_085955172.1\|175942_177150_-\|transposase	IS3 family transposase	Q9ZXG3	Shigella_phage	1.7e-100	63.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP018442

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP018438

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP018441

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection