CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP018870	Streptomyces sp. TN58 chromosome, complete genome	23 crisprs	csa3,DEDDh,WYL,cas4,cas3,c2c9_V-U4,DinG	12	10	4	0

1. NZ_CP018870

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP018870_1

• CRISPR_ID: NZ_CP018870_1
• CRISPR_location: 168182-168307
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_1

Consensus_repeat	Method
GGTCAGGGTCGGTGGGGTTGCCTTCGGGGGGGCAGGA	CRISPRCasFinder

spacers of NZ_CP018870_1

>1.1|168219|52|NZ_CP018870|CRISPRCasFinder
CCGGCGCCGTTGCCCACACCCGGTTCAGGGTCGGCGGGGGTCGCCCCTACCG

CRISPR arrays and Neighbor proteins around NZ_CP018870_1

CRISPR arrays

The CRISPR arrays of NZ_CP018870_1

>merge|NZ_CP018870|1|168182-168307|CRISPRCasFinder
GGTCAGGGTCGGTGGGGTTGCCTTCGGGGGGGCAGGACCGGCGCCGTTGCCCACACCCGGTTCAGGGTCGGCGGGGGTCGCCCCTACCGGGTCAGGGTCGGTGGGGTTGCCTTCGGGGGGTCAGGA

>NZ_CP018870|1|1|168182-168307|CRISPRCasFinder
GGTCAGGGTCGGTGGGGTTGCCTTCGGGGGGGCAGGA	CCGGCGCCGTTGCCCACACCCGGTTCAGGGTCGGCGGGGGTCGCCCCTACCG
GGTCAGGGTCGGTGGGGTTGCCTTCGGGGGGTCAGGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_159393493.1|171721_172606_-|hypothetical-protein	unknown	unknown	gnl|CDD|273344
NZ_CP018870.1|WP_030033937.1|163913_164819_+|allantoinase-PuuE	unknown	unknown	gnl|CDD|211797
NZ_CP018870.1|WP_075971917.1|161360_162053_+|HSP18-transcriptional-regulator	unknown	unknown	unknown
NZ_CP018870.1|WP_030033911.1|176684_177164_-|diadenosine-tetraphosphate-hydrolase	unknown	unknown	unknown
NZ_CP018870.1|WP_030031414.1|174309_174792_+|lamin-tail-domain-containing-protein	unknown	unknown	gnl|CDD|376421
NZ_CP018870.1|WP_030032941.1|160229_160625_-|DUF2267-domain-containing-protein	unknown	unknown	gnl|CDD|378360
NZ_CP018870.1|WP_030032943.1|159714_160161_-|DUF2267-domain-containing-protein	unknown	unknown	gnl|CDD|378360
NZ_CP018870.1|WP_030031413.1|175068_175281_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969562.1|177187_178768_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030033448.1|165056_165515_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969558.1|165829_166477_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_037665107.1|172892_173879_+|MsnO8-family-LLM-class-oxidoreductase	unknown	unknown	gnl|CDD|274646
NZ_CP018870.1|WP_051873430.1|162106_162487_+|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NZ_CP018870.1|WP_030032938.1|160766_161201_-|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl|CDD|223149
NZ_CP018870.1|WP_159393494.1|179100_180489_+|glycoside-hydrolase-family-15	unknown	unknown	gnl|CDD|273702
NZ_CP018870.1|WP_075969561.1|175502_176066_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379112
NZ_CP018870.1|WP_045324329.1|162628_163072_-|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl|CDD|380090
NZ_CP018870.1|WP_030032619.1|163496_163781_-|DUF3253-domain-containing-protein	unknown	unknown	gnl|CDD|371633
NZ_CP018870.1|WP_079273066.1|169118_169958_-|DUF2071-domain-containing-protein	unknown	unknown	gnl|CDD|378271
NZ_CP018870.1|WP_075969559.1|170213_171311_-|hypothetical-protein	unknown	unknown	gnl|CDD|312941

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_045324329.1|162628_163072_-|transglycosylase-SLT-domain-containing-protein	gnl|CDD|380090	pfam18013, Phage_lysozyme2, Phage tail lysozyme. This domain has a lysozyme like fold. It is found in the tail protein of various phages probably giving them the ability to degrade the host cell wall peptidoglycan layer.	1.07051e-05
NZ_CP018870.1|WP_030032941.1|160229_160625_-|DUF2267-domain-containing-protein	gnl|CDD|378360	pfam10025, DUF2267, Uncharacterized conserved protein (DUF2267). This domain, found in various hypothetical bacterial proteins, has no known function.	4.81335e-19
NZ_CP018870.1|WP_030031414.1|174309_174792_+|lamin-tail-domain-containing-protein	gnl|CDD|376421	pfam00932, LTD, Lamin Tail Domain. The lamin-tail domain (LTD), which has an immunoglobulin (Ig) fold, is found in Nuclear Lamins, Chlo1887 from Chloroflexus, and several bacterial proteins where it occurs with membrane associated hydrolases of the metallo-beta-lactamase,synaptojanin, and calcineurin-like phosphoesterase superfamilies.	9.32534e-19
NZ_CP018870.1|WP_030032943.1|159714_160161_-|DUF2267-domain-containing-protein	gnl|CDD|378360	pfam10025, DUF2267, Uncharacterized conserved protein (DUF2267). This domain, found in various hypothetical bacterial proteins, has no known function.	1.76098e-23
NZ_CP018870.1|WP_159393493.1|171721_172606_-|hypothetical-protein	gnl|CDD|273344	TIGR00927, retinal_rod, K+-dependent Na+/Ca+ exchanger. [Transport and binding proteins, Cations and iron carrying compounds].	1.91506e-10
NZ_CP018870.1|WP_037665107.1|172892_173879_+|MsnO8-family-LLM-class-oxidoreductase	gnl|CDD|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	2.83026e-114
NZ_CP018870.1|WP_051873430.1|162106_162487_+|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.47329e-21
NZ_CP018870.1|WP_030032938.1|160766_161201_-|Hsp20/alpha-crystallin-family-protein	gnl|CDD|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	1.051e-27
NZ_CP018870.1|WP_159393494.1|179100_180489_+|glycoside-hydrolase-family-15	gnl|CDD|273702	TIGR01577, Uncharacterized_glycosyl_hydrolase_MJ1610, oligosaccharide amylase. The name of this type of amylase is based on the characterization of an glucoamylase family enzyme from Thermoactinomyces vulgaris. The T. vulgaris enzyme was expressed in E. coli and, like other glucoamylases, it releases beta-D-glucose from starch. However, unlike previously characterized glucoamylases, this T. vulgaris amylase hydrolyzes maltooligosaccharides (maltotetraose, maltose) more efficiently than starch (1), indicating this enzyme belongs to a class of glucoamylase-type enzymes with oligosaccharide-metabolizing activity.	2.49536e-26
NZ_CP018870.1|WP_075969561.1|175502_176066_+|GNAT-family-N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.33929e-22
NZ_CP018870.1|WP_030033937.1|163913_164819_+|allantoinase-PuuE	gnl|CDD|211797	TIGR03212, uraD_N-term-dom, putative urate catabolism protein. This model represents a protein that is predominantly found just upstream of the UraD protein (OHCU decarboxylase) and in a number of instances as a N-terminal fusion with it. UraD itself catalyzes the last step in the catabolism of urate to allantoate. The function of this protein is presently unknown. It shows homology with the pfam01522 polysaccharide deacetylase domain family.	5.87648e-151
NZ_CP018870.1|WP_030032619.1|163496_163781_-|DUF3253-domain-containing-protein	gnl|CDD|371633	pfam11625, DUF3253, Protein of unknown function (DUF3253). This bacterial family of proteins has no known function.	5.35299e-27
NZ_CP018870.1|WP_079273066.1|169118_169958_-|DUF2071-domain-containing-protein	gnl|CDD|378271	pfam09844, DUF2071, Uncharacterized conserved protein (COG2071). This conserved protein (similar to YgjF), found in various prokaryotes, has no known function.	9.5383e-88
NZ_CP018870.1|WP_075969559.1|170213_171311_-|hypothetical-protein	gnl|CDD|312941	pfam09606, Med15, ARC105 or Med15 subunit of Mediator complex non-fungal. The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.	0.00319284

Protein sequences

>NZ_CP018870.1|WP_075969558.1|165829_166477_+|hypothetical-protein
MSDPRPREERRPAAPGAGAGDDTPGQAGVIGIGLAAVLTFALAQGSWQWFATYIGVTLFAVVFAFQVRPAWRPGVRTAYMRALVAYALVVGLCVAIAVAPVLQRGDWLFPMPGTRSRCGEIGRYEVLRTRAAVAGLPGGGAVPASVRESRREEAVADCLASTTTLWLPLYGAGAAVLVGAGAWYRDRNRAGRRPRAGSGPRQPADAAAGPGPGPA
>NZ_CP018870.1|WP_030033448.1|165056_165515_-|hypothetical-protein
MFRSTSRKQRFAMYAVSAAIVGGGVLVPTSAFAAPAAAGTTSVAAQAKSGHESDHKKEKWEKKDKKHDKGKKHQKHDKGKKHGKGKKNKVRDVENMPGCKFYQGKVYCEHKPDKPAPAPAPAPNTNPADKENPDKVPAKPNPAPPSAPKAAS
>NZ_CP018870.1|WP_030033937.1|163913_164819_+|allantoinase-PuuE
MSELQRDLVGYGAEPPHAAWPGGARVAVSLVLNYEEGGEQNVLEGDAASEGYLHEIVGAPPVRGGRDLNAESMFAYGARAGFWRIHRTLAAYGAPLTVFAVGQALERNPQAARAMGAAGWEVAGHGRRWIDYRQVPEEVERADIAETAAVIGRLVGRRPVGWYTGRTSANTRRLVAGGGFLYDSDDYSDDLPFYAETGGRPHLVVPYSLDANDFKFLIVHGFTTADDMLAYLVDTFETLWAEGGERPRMMSVGMHCRIIGRPGRIRALDGFLRHLEQRGGAWLATREEIARHWLSAHPPVR
>NZ_CP018870.1|WP_030032619.1|163496_163781_-|DUF3253-domain-containing-protein
MTGGNRQTDRQTDRQLERAILELLRRRAPTATICPSDAARAVYEGDGDGWRALMEPARRAARRLVAAGKVEITQGGRRVDPAKARGPIRIRRTP
>NZ_CP018870.1|WP_045324329.1|162628_163072_-|transglycosylase-SLT-domain-containing-protein
MPRPPLSPVEGISVSNTVIRRIAASKKALAGTVVALGVAGSMLAAVPAQAAPTSAKAIAQQMIKDPAQFAAFNNIVSRESGWNHTATNASSGAYGLVQALPASKMASAGADWKTNPATQIKWGLDYMNERYGSPVGAWNFWQTHHWY
>NZ_CP018870.1|WP_051873430.1|162106_162487_+|STAS-domain-containing-protein
MAEHPDRETGAKTGAEPVVEIVGRVVAVRPAGEIDIVTAPFLTRALTRALAHVDAAQADRIVTDCSRVTFCDSSGLNALLAARLRAVEAGTAIHLADPAPQLQRLLQMTGAAPLFPREDGPPARPA
>NZ_CP018870.1|WP_075971917.1|161360_162053_+|HSP18-transcriptional-regulator
MNETSPPVPPVRAPDAAAALQAIHRAVEDAHRASGGAEADTADTAGAAAGAAAGGGGPEQALEALRRLREVRERITGWESVLIETARGQGVSWAELAGPLGVASRQAAERRYLRLRPGAAGSTGEQRVQATRDARAADRSVTAWARDNAADLRRLAGQVTSLTGLPPGAEGAVGELNLALGGDDAARLVGPLAGTRPHLGPGDAELADRIDAMTRHADRLRRDSNDQRNS
>NZ_CP018870.1|WP_030032938.1|160766_161201_-|Hsp20/alpha-crystallin-family-protein
MLMRTDPFREMDRIVQQLSGASGTWSKPSVMPMDAYREDDVYVIAFDLPGVSTEAIDIDVERNMLTVKAERRPVAKGDTVQMELSERPLGVFSRQLMLADTLDTERIEADYDAGVLTLRIPIAERAKPRKIAIGGESGRKQISG
>NZ_CP018870.1|WP_030032941.1|160229_160625_-|DUF2267-domain-containing-protein
MPMRPDAFLDHVRESGEYPTRAEAERAARVVLALLGAHLVGTVRAELAARLPETYALILLNPLQAAEPLSPERFVRATAAWIEGATEKTALWDIGAVLSTVADAAGDTLTREILLQLPVGYDVLFGHPRPT
>NZ_CP018870.1|WP_030032943.1|159714_160161_-|DUF2267-domain-containing-protein
MYDQPRPNQAPPAMTFDRMLERVRYEGAYPTAERAEEAVRAVLAALGRQVTGDERVDLAQALPVEAALALTAQIPGVEQLTGWGFVKDLAARTGTTPAIARWDTGAVLAVVARLAGPDLLARILNRLPDGYALLFGQAQLRRPEPAAA
>NZ_CP018870.1|WP_079273066.1|169118_169958_-|DUF2071-domain-containing-protein
MQHPPPPGPGPAAPGPAAPSPAAPAGLGPAAPGPAAPAEPITPDAPRHPGVDRPLLTQSWLDLTFVHWPADPADVAPLLPAGTAPDTLDGVTYVGLVAFRMHRVGWLRLPGIPYLGSFPETNVRLYSIDGHGRRGVVFRSLDASRLIPVLAARTVFRLPYQWSRMSVRRDGPTLTYTSRRHWPGPRGAHSTLTVRTGPPLTQPTALEHFLTARWALHSDFRGRLLYLPNSHPRWPLHHAELLRCDEDLTVAAGLPAPAGPPASVLYSPGVPVRFTRPTG
>NZ_CP018870.1|WP_075969559.1|170213_171311_-|hypothetical-protein
MSRKKHVANIAGLSCVTAILAGTAGVAVAQPSALPTAAPAAVCSLKGGEIHGNGFALKQTYDVKRSGKTIARVAAGPKGDIRVGITGAGPFSVGTVKCASTGSTAASTKTDMAAATARGAAAAQQAARGGASKTQAAAIGRKAAASEAKRLGLAPAVVNQVTNNVTNIVNNTIIGGSNNTIGGTQIGNGNTQGGTQGAGNGNTQGGTQGAGNGNTQGGTQGGGNGNTQGGTQGGGTGNTQGGTQGGGNGNTQGGTQGGGTGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGTGSTQGGTQGGGTGSTQGGTQG
>NZ_CP018870.1|WP_159393493.1|171721_172606_-|hypothetical-protein
MNRKFETSETPRPKRRGFRLATAVAAAAIAGGVLIPTSSAMAAPTTSVESVVSHNQHDHKKKHDHKKHEDNHKKKKRNKHGGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQG
>NZ_CP018870.1|WP_037665107.1|172892_173879_+|MsnO8-family-LLM-class-oxidoreductase
MLDIPLSALEVAMVQTGTRAVDTLRDTAAFAQGMERLGYRRLWYAEHHHSPAIGAFPPVVLTAHAAASTSVIRLGSGGVLAPNHAPLTVAEQFGTLAALHEDRIDLGIGRGPGTFDEAIARALRRGAGPATDAEYRRDVAAVLSFLVEEVALGPLPEPWLLVSSAAGAALAAALGLPVAVAHHIRPDNTLAVVEGYRAAFTASRWCERPRVMLCVETVCAPTREEAVWRAGPMNVVKAGLLKGLSQVPFPTPAQAAAHPFTGQERQALDGFRAQQAVGAPEAVVERLARLAGETGAQELMLATPVYDLGARIASYELVRKYWGAAGSS
>NZ_CP018870.1|WP_030031414.1|174309_174792_+|lamin-tail-domain-containing-protein
MSASRATRRTLAALLAAGTLLGAAALPAAADDHRRGGHRGPHSSLSIGDVRYESGPRHDRSNRALNREWVEIRNTGRHSVNLRGFTLTDQQGNRYRFPDFRLDGRSAVKVHTGQGRDTRHDLYQDRNRQIWNDRDTATLRDQRGNVIDTESWGRRGHHRG
>NZ_CP018870.1|WP_030031413.1|175068_175281_+|hypothetical-protein
MATDAVGRFLAALEPHRRDAVAARPRQEQERLAAAWEEELGSDDELDTLDELSPPAAEAEAARRVMDRES
>NZ_CP018870.1|WP_075969561.1|175502_176066_+|GNAT-family-N-acetyltransferase
MRGVRDRLEVSPGLRLRRWSPADAGAVLAAFAEPVMARQAAEPGVTPAAARRWLEARAEQWDAGSGYAFAVVDAADVVLGHVAVGSVERRHGTGWVSYWTTAAARGRGVASGGCRAVAAWAFEDAGLFRLELGHRVDNPASCRVARAAGFAVEGLQRRRLRYDGVRYDVELHARLATDPAPATRPGG
>NZ_CP018870.1|WP_030033911.1|176684_177164_-|diadenosine-tetraphosphate-hydrolase
MTGDWRTDRIGTALRGENPTVLRRLTSGFAVIGDVQFLPGYSVLLVDDPQVQRLSDLPKAKRLSFLSDMDQLGEAVERACRRLDPAFRRVNLEILGNKDPFLHAHVWPRFAWEPADAVRAPVWLYPRDRWSDEQSRLGPQHDPLREAIGSELDRLRPTA
>NZ_CP018870.1|WP_075969562.1|177187_178768_-|hypothetical-protein
MSTTAAEDEDLVTPSPPTGPHTGPRPLLRTLPTAAAATLATAAGALVAVGCFLGLYIRPTSDDWCAAWKTRDLGVLGITADFYTTQNGRIANAFLSGLLYGGGPAGTKILPTLITLALTAALVLLGRRLLHALGHTPPLLALTACALALQALLYFAGTRSYQVLLWAPATISHTVPSVIGLWALLLALATAAHPRPAVRTAGLAGALLTGFALGTLSEPFALVSALLAALTALLCLPRLHLTTTWRPFTWCLLWCAGLACGLTVLHTSPGARWRRAQQPEKPPILSTGELRATFEDWLRIWDTVTGQWAYLAAAAAGLLLGLAATLRTPRPAPRRVPASGARPGAGRATRTALLLLPLPVVILGSFAVAAGLRSGYGPTGWTYARTWTSFLLPMELALCGYGALLGAWAGPRLAARRPAAAATATTAALCLTLAATASLVPHLQQLTTTTVARSIAWDAQNTRIRTEAAHGATDVGYRPLPIGHLAEPFFTADYDRDWVAACVSRWYGVDRIHRLTGRGGAGTPGP
>NZ_CP018870.1|WP_159393494.1|179100_180489_+|glycoside-hydrolase-family-15
MPVVLGCWAVAAAVLAGASVPVCGAGGHAPLSGFTAPTVGVLSNVTAAEGVSASRAAGARYVEGSNVLRLASGRWLYLPAGRTVSVVVGAGDAGALRQIGQSRAWLASGRIPGRSAAERAAAARALLAMRALLRPNGAMAAGWSPGWMYSWPRDASFACAAFAHTGHDAEAFGILRHSAATQRGDGSWEARTKLDGSGPPDGRRWQLDANGWVPWSVWQWYRAAPAEGRRARLATLYPMVARAADRAARSLGADGLPPASPDYWELMTSSTNIGTAAPLLAGLNASADLAREAGRPGDAARWARAARRLSAGISKRFLPLGYQRTVDGRHGRDSAVAFMTPPFNAAPAGLEAVLESTWRALRLPNGGLTPGDDPGAPWGATAWTPSTAFFALAWAAGGRPAKAGPVLEWVLSKRNALGELPEKVDSAGRAASVAPLAWTGSIVLLSLVALESGGLPAPPPGR

Crispr_ID: NZ_CP018870_2

• CRISPR_ID: NZ_CP018870_2
• CRISPR_location: 1502487-1502615
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_2

Consensus_repeat	Method
GGCCGAACCCCATCCAGCCCCGCCGGCGATTGAGGCGC	CRISPRCasFinder

spacers of NZ_CP018870_2

>2.1|1502525|53|NZ_CP018870|CRISPRCasFinder
CGGGTTTGGGGCGGAGCCCCTGGGGGTGGCCCGCACCCGACCCTGCGGCCGGG

CRISPR arrays and Neighbor proteins around NZ_CP018870_2

CRISPR arrays

The CRISPR arrays of NZ_CP018870_2

>merge|NZ_CP018870|2|1502487-1502615|CRISPRCasFinder
GGCCGAACCCCATCCAGCCCCGCCGGCGATTGAGGCGCCGGGTTTGGGGCGGAGCCCCTGGGGGTGGCCCGCACCCGACCCTGCGGCCGGGGGCCGACCCCCATCCAGCCCCGCCGGCGATTGAGGCGC

>NZ_CP018870|2|2|1502487-1502615|CRISPRCasFinder
GGCCGAACCCCATCCAGCCCCGCCGGCGATTGAGGCGC	CGGGTTTGGGGCGGAGCCCCTGGGGGTGGCCCGCACCCGACCCTGCGGCCGGG
GGCCGACCCCCATCCAGCCCCGCCGGCGATTGAGGCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_030012385.1|1497429_1497624_-|50S-ribosomal-protein-L35	unknown	unknown	gnl|CDD|234676
NZ_CP018870.1|WP_007263143.1|1496935_1497322_-|50S-ribosomal-protein-L20	unknown	unknown	gnl|CDD|179959
NZ_CP018870.1|WP_045324123.1|1502740_1503943_+|alanine-racemase	unknown	unknown	gnl|CDD|143488
NZ_CP018870.1|WP_075970014.1|1506209_1507580_-|glutamine-synthetase	unknown	unknown	gnl|CDD|223252
NZ_CP018870.1|WP_030037392.1|1495939_1496800_-|RNA-methyltransferase	unknown	unknown	gnl|CDD|223640
NZ_CP018870.1|WP_045323915.1|1494615_1495779_-|PAS-domain-containing-protein	unknown	unknown	gnl|CDD|225115
NZ_CP018870.1|WP_075970011.1|1490808_1493337_-|phenylalanine--tRNA-ligase-subunit-beta	unknown	unknown	gnl|CDD|234804
NZ_CP018870.1|WP_030030756.1|1493336_1494464_-|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl|CDD|234780
NZ_CP018870.1|WP_045324119.1|1510066_1510774_+|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl|CDD|336781
NZ_CP018870.1|WP_030037391.1|1497728_1498442_-|translation-initiation-factor-IF-3	unknown	unknown	gnl|CDD|234582
NZ_CP018870.1|WP_037664976.1|1512707_1513823_+|TDT-family-transporter	unknown	unknown	gnl|CDD|187760
NZ_CP018870.1|WP_030029660.1|1507657_1508404_+|FadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225097
NZ_CP018870.1|WP_045323910.1|1499984_1501229_-|type-VII-secretion-associated-serine-protease-mycosin	unknown	unknown	gnl|CDD|274856
NZ_CP018870.1|WP_075971998.1|1504792_1506172_-|aldehyde-dehydrogenase	unknown	unknown	gnl|CDD|365919
NZ_CP018870.1|WP_030029663.1|1510863_1511709_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_045324120.1|1508539_1510021_+|ethanolamine-permease	unknown	unknown	gnl|CDD|129986
NZ_CP018870.1|WP_045324118.1|1511713_1512637_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176112
NZ_CP018870.1|WP_030037390.1|1498768_1499152_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030031919.1|1504000_1504786_-|3-oxoacyl-ACP-reductase	unknown	unknown	gnl|CDD|180371
NZ_CP018870.1|WP_075970012.1|1499222_1499963_-|SseB-family-protein	unknown	unknown	gnl|CDD|377787

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_030012385.1|1497429_1497624_-|50S-ribosomal-protein-L35	gnl|CDD|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	9.03319e-21
NZ_CP018870.1|WP_007263143.1|1496935_1497322_-|50S-ribosomal-protein-L20	gnl|CDD|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	2.70508e-59
NZ_CP018870.1|WP_045324123.1|1502740_1503943_+|alanine-racemase	gnl|CDD|143488	cd06813, PLPDE_III_DSD_D-TA_like_2, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2. This subfamily is composed of uncharacterized bacterial proteins with similarity to eukaryotic D-serine dehydratases (DSD) and D-threonine aldolases (D-TA). DSD catalyzes the dehydration of D-serine to aminoacrylate, which is rapidly hydrolyzed to pyruvate and ammonia. D-TA reversibly catalyzes the aldol cleavage of D-threonine into glycine and acetaldehyde, and the synthesis of D-threonine from glycine and acetaldehyde. DSD and D-TA are fold type III PLP-dependent enzymes, similar to bacterial alanine racemase (AR), which contains an N-terminal PLP-binding TIM barrel domain and a C-terminal beta-sandwich domain. AR exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Based on their similarity to AR, it is possible members of this family also form dimers in solution.	0
NZ_CP018870.1|WP_075970014.1|1506209_1507580_-|glutamine-synthetase	gnl|CDD|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	1.45887e-139
NZ_CP018870.1|WP_030037392.1|1495939_1496800_-|RNA-methyltransferase	gnl|CDD|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	6.01161e-67
NZ_CP018870.1|WP_045323915.1|1494615_1495779_-|PAS-domain-containing-protein	gnl|CDD|225115	COG2205, KdpD, Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms].	1.962e-55
NZ_CP018870.1|WP_075970011.1|1490808_1493337_-|phenylalanine--tRNA-ligase-subunit-beta	gnl|CDD|234804	PRK00629, pheT, phenylalanyl-tRNA synthetase subunit beta; Reviewed.	0
NZ_CP018870.1|WP_030030756.1|1493336_1494464_-|phenylalanine--tRNA-ligase-subunit-alpha	gnl|CDD|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0
NZ_CP018870.1|WP_045324119.1|1510066_1510774_+|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl|CDD|336781	pfam07722, Peptidase_C26, Peptidase C26. These peptidases have gamma-glutamyl hydrolase activity; that is they catalyze the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to pfam00117, but contain extensions in four loops and at the C-terminus.	9.26621e-81
NZ_CP018870.1|WP_030037391.1|1497728_1498442_-|translation-initiation-factor-IF-3	gnl|CDD|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	2.87512e-96
NZ_CP018870.1|WP_037664976.1|1512707_1513823_+|TDT-family-transporter	gnl|CDD|187760	cd09320, TDT_like_2, The Tellurite-resistance/Dicarboxylate Transporter (TDT) family. The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).	9.85521e-98
NZ_CP018870.1|WP_030029660.1|1507657_1508404_+|FadR-family-transcriptional-regulator	gnl|CDD|225097	COG2186, FadR, Transcriptional regulators [Transcription].	2.61405e-32
NZ_CP018870.1|WP_045323910.1|1499984_1501229_-|type-VII-secretion-associated-serine-protease-mycosin	gnl|CDD|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	4.72633e-95
NZ_CP018870.1|WP_075971998.1|1504792_1506172_-|aldehyde-dehydrogenase	gnl|CDD|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	0
NZ_CP018870.1|WP_045324120.1|1508539_1510021_+|ethanolamine-permease	gnl|CDD|129986	TIGR00908, putative_ethanolamine_permease, ethanolamine permease. The three genes used as the seed for this model (from Burkholderia pseudomallei, Pseudomonas aeruginosa and Clostridium acetobutylicum are all adjacent to genes for the catabolism of ethanolamine. Most if not all of the hits to this model have a similar arrangement of genes. This group is a member of the Amino Acid-Polyamine-Organocation (APC) Superfamily. [Transport and binding proteins, Amino acids, peptides and amines].	2.17191e-140
NZ_CP018870.1|WP_045324118.1|1511713_1512637_-|LysR-family-transcriptional-regulator	gnl|CDD|176112	cd08420, PBP2_CysL_like, C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold. CysL, also known as YwfK, is a regular of sulfur metabolism in Bacillus subtilis. Sulfur is required for the synthesis of proteins and essential cofactors in all living organism. Sulfur can be assimilated either from inorganic sources (sulfate and thiosulfate), or from organic sources (sulfate esters, sulfamates, and sulfonates). CysL activates the transcription of the cysJI operon encoding sulfite reductase, which reduces sulfite to sulfide. Both cysL mutant and cysJI mutant are unable to grow using sulfate or sulfite as the sulfur source. Like other LysR-type regulators, CysL also negatively regulates its own transcription. In Escherichia coli, three LysR-type activators are involved in the regulation of sulfur metabolism: CysB, Cbl and MetR. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.573e-63
NZ_CP018870.1|WP_030031919.1|1504000_1504786_-|3-oxoacyl-ACP-reductase	gnl|CDD|180371	PRK06057, PRK06057, short chain dehydrogenase; Provisional.	0
NZ_CP018870.1|WP_075970012.1|1499222_1499963_-|SseB-family-protein	gnl|CDD|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	3.46709e-20

Protein sequences

>NZ_CP018870.1|WP_045323910.1|1499984_1501229_-|type-VII-secretion-associated-serine-protease-mycosin
MTSARVEARTRIHTGRRTFRSAAVLSATALLAATVTATATPAAADTIRDRQWGLLALRAEEAWGTTRGDGVTVAVLDTGVDESHPDLSGQVLAGTDLIGTGAGPGDRAWARHGTAMASIIAGHGHGPSRGQGVLGIAPQARILPVRVILEEGDPGRAKARESKGGALAEGIRWATDHGADVINLSLGDDSDSAHHEADEDEAVQYALAKGVVVVASAGNGGETGDRVSYPAAYPGVIAVTAVDRRGRKAKFSTRNWYATVSAPGVDVVIADPDRSYYEGWGTSAAAAFVSGAAALVKAAHPDLSPAQIKKLLEDTASDSPAGGRDDARGHGTVDPAAALQVAGTMRAEAAVPAPAAAASRYFGPGPEPARPPERGDRLRAPAAAVAGAALLVLAAVLARRPRRGPRDRDPYPAQ
>NZ_CP018870.1|WP_075970012.1|1499222_1499963_-|SseB-family-protein
MANKNIPDPGFSDDDGSADPELTAALAAWAEDRTQEPRVLAALKGARLLVPVVAMLGEVETDPETGLKREKTSDMAVPTLRAGDRRALPAFTSIASLALWDPAARPVAVPLHQALAAAAHEKADTVVLDLAGPVAYQLTGRALLALAEGRTDTDPLADPAVREAVRAVVAAEPAVLRAHLGPGGAEADGILAIVPAPDAEAPAAARRVAEALAADTTLRARLVRGLNLALLPPDAPVPPGEPLFTR
>NZ_CP018870.1|WP_030037390.1|1498768_1499152_+|hypothetical-protein
MTDATPPTSTDTTADHAPDYDAMTRDIADVPAVEVITTVAVHLLSAAAVNLGLDKPDSEHKDLDEARKLITALAGLVTASATEISSFHAAPLRDGLKSLQLAFREASIVPDEPGQGPGEKFTGPVFG
>NZ_CP018870.1|WP_030037391.1|1497728_1498442_-|translation-initiation-factor-IF-3
MWCYRGGSISTEPRINDRIRVPEVRLVGPSGEQVGIVPLAKALELAQEYDLDLVEVAASARPPVCKLMDYGKFKYESAMKAREARKNQAHTVIKEMKLRPKIDPHDYDTKKGHVVRFLKQGDKVKITIMFRGREQSRPELGYRLLQRLASDVEELGFIESNPKQDGRNMIMVLGPHKKKTEAMAEAREAQAARKAERQGAAAADEATPSQEAAPVEATDAKDAEVTEADAGEANAEA
>NZ_CP018870.1|WP_030012385.1|1497429_1497624_-|50S-ribosomal-protein-L35
MPKNKTHSGTKKRFKVTGSGKVLRERAGKRHLLEHKSSRVTRRLTGNAEMAPGDAAKIKKLLGI
>NZ_CP018870.1|WP_007263143.1|1496935_1497322_-|50S-ribosomal-protein-L20
MARVKRAVNAHKKRRAILEAASGYRGQRSRLYRKAKEQVTHSLVYNFNDRKKRKGDFRQLWIQRINAAARQNGMTYNRLIQGLKAANIEVDRKILAELAVNDANAFAALVEVAQKALPADVNAPKAAA
>NZ_CP018870.1|WP_030037392.1|1495939_1496800_-|RNA-methyltransferase
MGHPAELISPRSPRVAAARRLARRNFRTKERRFIAEGPQAVREAVEHRGPTGEPTLIELFATVEAAERYSDIIGAAQAAGARVHQASDEVLAEVSQTVTPQGLVGVCHFLDSPFEEILKAAPRLVAVLAHVRDPGNAGTVLRCADAAGADAVVLTDASVDLYNPKSVRASVGSLFHLPVAVGVPVEQAVEGLRAAGVRILAADGAGEDDLDAELDAGTMGGPSAWVFGNEAWGLPEETRALADAVVRVPIHGKAESLNLATAAAVCLYASARAQRAPGGCRSVTPS
>NZ_CP018870.1|WP_045323915.1|1494615_1495779_-|PAS-domain-containing-protein
MCGVPPQAGSSARARGAGPAAPRPVPAARAAAEAPGAGFGPGFAVDPDHLPDGLVVADHTGRVVCFNAAAARITALAPEQALGAPIERALPLEDLEGRRWWALTDPYGGLATRRGQPERNLLLPGGREVLVSASYIRTHPTGPVRRLVVTLRGTEARRRTERSHAELIATVAHELRSPLTSVKGFTATLLAKWERFTDDQKRLMLETVDADANRVTRLIAELLDISRIDSGRLEVRRQPVDIATAVGRHVQALTANGQAPERFLVSISRPLPDLWADPDKIDQILGNLLENAVRHGEGTVTIGVSPHEKGTAVTVSDEGPGIPEESMARVFTRFWRGSKRGGTGLGLYIVKGIVEAHGGTITVGRGPGGGAEFRFILPVGAPAYLSQ
>NZ_CP018870.1|WP_030030756.1|1493336_1494464_-|phenylalanine--tRNA-ligase-subunit-alpha
MSAPNKSYDPVEVEALKPEEIERMRDEALAAFAAAGDLDALREAKTAHMGDRSPLALANREIGALPPQAKADAGKRVGQARGAVNKAFGARTVELEAERDERVLVEEAVDVTLPYDRVPAGARHPLTTLMDRVADIFVAMGYEVAEGPEVEAEWFNFDALNFTPDHPARQMQDTFFVQGPEGTEGDESGVVLRTHTSPVQARSLLERKPPVYIVCPGRVYRTDELDATHTPVFHQVELLAVDEGLTMADLRGTIDHMVKELFGEETTTRLRPHFFPFTEPSAEMDMQCYVCRGESVGNPDRPCRTCSSEGWIELGGCGMVNPKVLTACGVDPEKYSGFAFGFGIERMLMFRHNVEDMRDMVEGDVRFTRPFGMEI
>NZ_CP018870.1|WP_075970011.1|1490808_1493337_-|phenylalanine--tRNA-ligase-subunit-beta
MRVPLSWLREYVDLPAGETGRDVAAKLVDAGLEVETVEQLGAGLKGPLVVGQVLTIEELEGFRKPIRFCTVDVGAANGTGEPQEIVCGARNFAVGDKVVVVLPGAVLPGDFAIAARKTYGKTSHGMICSGEELGMGDDGTHGIIVLPPEHEAGTDAIELLQLVDEVLHIDVTPDRGYCMSLRGIAREVATAYGLPLRDPALLDVPGPNSYGYPVKIDDPAGCDRFTARTVTGLDPEARSPIWLQRRLQKAGMRPISLAVDITNYVMLELGQPLHAYDRSRIDGTIGVRRAEQGEKFTTLDGVKRTLDAEDLVITDNSGPIGLAGVMGGANTEIADSVTDPETGAVTGTTDVVIEAAHFDSVSISRTARRMKLSSEASKRFERGVDPLAAAAAAQRTVDLLVLLAGGTAEAGVTEVVAPGAPRTIAMAADHPDRVAGMEYGRETVVRRLQEIGCDVYGQDELVVTLPSWRPDLAAPNDLAEEVIRLEGYGNLPSTLPQVPSGRGLTARQQLHRRVGRALAGAGYVEALSYPFLGEGVFDQLQLPAHDAARQVVKLVNPLSDEEPALRTTLLPGLLGALRRNDSRGSHDLALFETGSVFRAADRPGVAVRLPVDRRPTDEEVATLDAALPAQPRYAAVVLAGAREQAGWWGKGRPADWADAIQAARALAVEAGAELVVRQGQYGPWHPGRCAELVVTVGGVEQVIGHAGELHPRVVKAMGLPARTSAMELDLDRLAAAGGEAVQAPRISSFPVATQDVALIVDASVPAASVEAALRKGAGELLESLRLFDVFTGDQVGAGKKSLAYALRFRASDRTLTAEESTAARDAAVALAGERTGAVLRGA
>NZ_CP018870.1|WP_045324123.1|1502740_1503943_+|alanine-racemase
MNSAAADRARYDRATAHLDAPLAIVDLAAFDANADDLVRRAGGKPVRVASKSVRCRALLERVLARPGFAGIMSYTLAESLWLARSGFEDVLLAYPSADRAGFGELANDAKLAAAVTVMVDDPAQLELIDGARDGGGEEIRVCLELDTSLRLLGGRIRVGARRSPLREPAELAALARAVAARPGFRVVGLMAYEGHVAGVGDALAGRPLRSRAIRLMQGAARRELAARRAEVVAAVRAVVPDLEFVNGGGTGSVQQTAAEDAVTEIAAGSGLYVPRLFDNYTSFRGRPAALFAQPVVRRPGVGVVTVLGGGYPASGAAGSDRLPVPYLPQGLGYDPQEGAGEVQTPLLGSPADDLLIGDRVWFRHAKAGELCERFDTLHLVEGDRVADSVPTYRGEGRTFL
>NZ_CP018870.1|WP_030031919.1|1504000_1504786_-|3-oxoacyl-ACP-reductase
MSNEEIICRRLVGRTAVITGAGSGIGLATARRLASEGANVVCADIDETAGKAAAEEVAGLFVKVDVTDKEDVDALFKTAFDTYGSVDIAFNNAGISPPDDDSILTTELDAWRRVQDVNLTSVYLCCKAALPYMQRQGRGSIINTASFVAVMGAATSQISYTASKGGVLAMSRELGVQFAREGIRVNALCPGPVNTPLLQELFAKDPERAARRLVHIPLGRFAEPTEIAAAVAFLASDDSSFVNATDFLVDGGIAGAYVTPL
>NZ_CP018870.1|WP_075971998.1|1504792_1506172_-|aldehyde-dehydrogenase
MSDAPAPSPLRVLNPATEELVAVVPAATRDDVDAAVARAAAAQRAWAAAAPADRARLLRRFAAVVDGHIEELALLEVREAGHTIGNARWEAGNVRDLLDFAAGGVERLNGRQIPVAGGIDVTFLEPLGVIGVIAPWNFPMPIAAWGLAPALAAGNAVILKPAETTPLTALRLAELALEAGIPEHLFQVLPGHGDTAGDALVEHPGVAKIVFTGSTRVGKQIMAKCADRVKRVTLELGGKSPNIVFADADLEAAAAAAPMAFLDNTGQDCCARTRILVQRSAYDRFLDLLAPGIAAVTVGDPLDEKTQVGPLISRTQLDRVRSFVTDDLTTVRGTAPEGPGFWYPPTLVTGVAPTAPVAAEEIFGPVAVVLPFEDEEDAVRLANATEYGLSGSLWTRDIGRALRVSRAVAAGNLSVNSHSSVRYWTPFGGYKQSGLGRELGPDALTAFTETKNVFISTEA
>NZ_CP018870.1|WP_075970014.1|1506209_1507580_-|glutamine-synthetase
MVDRKPPLAPEELRALVASGEIDTVVLAFPDMQGRLQGKRFAAQFFLDEVLAHATEGCNYLLAVDTDMNTVDGYEMSSWERGYGDFAMHPDPATLRRIPWNPGSAFILADLAWNDGTPVVAAPRQILRRQLDRLAEHGYTAMVGTELEFMVFKDTYEQAWNAGYRGLTPANQYNIDYSVLGTGRIEPLLRRIRNEMQAAGLTVESAKGECNLGQHEIAFRYDEALTTCDQHSVYKTGAKEIASQEGVSLTFMAKYDEREGNSCHIHLSLTDADGRNAMAGEGHGEHGMSPVMRHFLAGQLAALRDFSLLYAPNINSYKRFRPGSFAPTAVAWGLDNRTCALRVVGHGRSMRFENRLPGGDVNPYLAVAGLVAAGIYGIENRLELPPICTGNAYTGDYAHVPATLREAAELWENSEIAKAAFGPEVVAHYRNMARVELDAYDSAVTDWELRRSFERL
>NZ_CP018870.1|WP_030029660.1|1507657_1508404_+|FadR-family-transcriptional-regulator
MTDTASQGDAARRLDPVLRQVRAGNGFEEALEQILQVVRLGLVPGGERLPPERELAERMGISRVTLREVLKVLQDQGLVEARRGRYGGTFVLPRPDTPAGGAEEELRRRVAGVDIEDVLRFREVLEVGAAGLCASQGLSEEGTERLLAALGATHDAPLADYRRQDTLFHLTLCELAGSATLTAQYAAVRATVNDLLDCIPLLVRNLEHSQQQHTALVESVLERDAAGARETMREHCCGTAALLRGFLA
>NZ_CP018870.1|WP_045324120.1|1508539_1510021_+|ethanolamine-permease
MADDIETRLTAGPAPTTSPAAGGDGPDDYLERRTLRRGSAGWLLLTGLGVAYVVSGDFSGWNVGLDKGGFGGLAIATVLMGTMYACLVFSLAELSTILPTAGGGYGFARRALGPWGGFLTGTAILIEYILAPAAIVIFIGDYVESLGLFGLTSSWPVYLGCFVVFIGVHLWGVGEALRFSLVVTAVAVAALLIFAVGAFTEFSADGLNDIPVDPDAFGSNSWLPLGVLGIWAAFPFGMWFFLGVEGVPLAAEEAKDPVRSMPKALAIAMGILTLLALITFFAATGAQGADAVKSAGNPLVVALEGDGGPTALSRFVNYAGLAGLVASFFSLIYAGSRQLFALSRAGYLPRFLSLTSKRKAPYLGLIIPGAIGFALAAATGNGARMLNIAVFGATISYALMALSHIVLRRREPRLERPYRTPGGILTSSVAFVLALSALVATFLVDKDAAFIALAVYAVALAYFAVHSRHHLVASAPEEEFAALAEAEAELARD
>NZ_CP018870.1|WP_045324119.1|1510066_1510774_+|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MPRPLIGITTYVEESTRYGVWDVPASLVPTGYHELVQAAGGAAVLLPPDEPGSAAEVLSRVDGLVVAGGPDVDPVHYGAARDPRTGAPAAVRDRWELALINAALEADVPVLGICRGMQALNVALGGTLIQHIDGHVDTPGVMSWHPVRPVPGTRYADLVPDEAQVPTYHHQAVERLGRGLVASAHALDGTVEAIELPDPARWVLGVQWHPERDDDTRVMASLITAAAVRGAVPVA
>NZ_CP018870.1|WP_030029663.1|1510863_1511709_+|hypothetical-protein
MALRPSGGHAGWVSTDRHQASKGPVAGFLDNPVVGMAPWIVFSLLVGPGRFELAVGLALAAAVTLIAVGHLVHRGSSWKLLELADVVFFASMAVIGALADEGTLRWLETYAGEVANIALTVIAFGSMAVGMPFTIQYAREQVDPSLWHTRGFLRTNYMITGAWGIAFLIAAAAGAYGDLVLHNPDNIWTGWIIQILAIVAAVKFTVWYPDVARARGVREAAGLPPEPTEWAGFLVPLAGLLVPIGIAVLIFDNMWWLGAALIVAGTLLTKTLQARSRTPQT
>NZ_CP018870.1|WP_045324118.1|1511713_1512637_-|LysR-family-transcriptional-regulator
MGDEEWVPLAHRVPDLGALELLLAVARVGSLSGAARRLGITQPAASSRIRAMESRLGVALVDRSPRGSTLTAEGALVTDWARRVVEAAEAFDAGAQALRGRRDSRLRVAASMTIAEYLLPGWLIALRGQRPDTAVSLHAGNSAVVVQRVLTHEADLGFVEGLTVPEGLDSAVIAQDRLVVAVAPVHPWARRTRGVEAAELAATPLILRERGSGTRQVLDAALAGHGGLAAPLLELASTTAVKAAALGGAGPCVLSELAVVDELAARRLVEVPVSGAGLGRALRAVWPAGARPAGPARDLLSLTRGTP
>NZ_CP018870.1|WP_037664976.1|1512707_1513823_+|TDT-family-transporter
MATTVVRPRTLTEPAPTAHKAPALRHLGPNWYACVMGTAIVANAGATLPYQLPGQRVACQLVWALSAAALAVLLTARAGHWLHHRDQARAHLLDPAVAPFYGCLSMALLAVGGGTLVVGSDLIGTGAAVAAGAVLFTAGTAIGLVGAVAVPYLMVVRHKVEPRQATPVWLLPVVAPMVSAAVGPLLIPHLPPGQPREALLLACYAMFGISLLATLLMLPLIFGRLIVGGPLPLALTPTLFLVLGPLGQSTTAVNLLADMAPQAVGAPYAGALGAFAFVYGVPVTGFALLWLALAVCLLVRAARAGMGFAMTWWALTFPVGTCVTGAAGLARHTGLTALAWLAAALFLALLAAWLLATAHTLRGLLTGRLLS

Crispr_ID: NZ_CP018870_3

• CRISPR_ID: NZ_CP018870_3
• CRISPR_location: 1698869-1699231
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 7 spacers

Consensus repeat of NZ_CP018870_3

Consensus_repeat	Method
CCGCGGTCGTCNCGNCGN	CRT

spacers of NZ_CP018870_3

>3.1|1698887|21|NZ_CP018870|CRT
GGGTAGGACGGGCGGTCGCCG
>3.2|1698926|18|NZ_CP018870|CRT
GGGTAAGAGGGACGGTCG
>3.3|1698962|18|NZ_CP018870|CRT
AAGGAGGGACGGTCGCCA
>3.4|1698998|33|NZ_CP018870|CRT
GGGTAGGACGGACGGTCACCACCACGGTCGTCA
>3.5|1699049|42|NZ_CP018870|CRT
AAGCCGCCGCCACCGCCACCGCCACCGCCGGAGGGGCGCCCG
>3.6|1699109|30|NZ_CP018870|CRT
TAGCCGCCACCACCGCCGGCCGGCCGGCCG
>3.7|1699157|57|NZ_CP018870|CRT
AACGGGGGACGGTCGCCCCCACGGTCGTCACGGCCCCCGCGGTAGCCGCCCCTGTCA

CRISPR arrays and Neighbor proteins around NZ_CP018870_3

CRISPR arrays

The CRISPR arrays of NZ_CP018870_3

>merge|NZ_CP018870|3|1698869-1699231|CRT
CCACGGTCATCCCGGCGCGGGTAGGACGGGCGGTCGCCGCCCCGGTCGTCGCGACGCGGGTAAGAGGGACGGTCGCCGCGGTCGTCGCGGCGGAAGGAGGGACGGTCGCCACCGCGGTCGTCACGGCGCGGGTAGGACGGACGGTCACCACCACGGTCGTCACGGCGGTCGTCACGGCGGAAGCCGCCGCCACCGCCACCGCCACCGCCGGAGGGGCGCCCGCCGCGGTCGTCACGGCGGTAGCCGCCACCACCGCCGGCCGGCCGGCCGCCGCGGTCGTCGCGACGGAACGGGGGACGGTCGCCCCCACGGTCGTCACGGCCCCCGCGGTAGCCGCCCCTGTCACCGCCGTCGTTGCGCCGA

>NZ_CP018870|3|1|1698869-1699231|CRT
CCACGGTCATCCCGGCGC	GGGTAGGACGGGCGGTCGCCG
CCCCGGTCGTCGCGACGC	GGGTAAGAGGGACGGTCG
CCGCGGTCGTCGCGGCGG	AAGGAGGGACGGTCGCCA
CCGCGGTCGTCACGGCGC	GGGTAGGACGGACGGTCACCACCACGGTCGTCA
CGGCGGTCGTCACGGCGG	AAGCCGCCGCCACCGCCACCGCCACCGCCGGAGGGGCGCCCG
CCGCGGTCGTCACGGCGG	TAGCCGCCACCACCGCCGGCCGGCCGGCCG
CCGCGGTCGTCGCGACGG	AACGGGGGACGGTCGCCCCCACGGTCGTCACGGCCCCCGCGGTAGCCGCCCCTGTCA
CCGCCGTCGTTGCGCCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_030028992.1|1707527_1708031_+|HNH-endonuclease	unknown	unknown	gnl|CDD|224321
NZ_CP018870.1|WP_079273422.1|1697082_1697850_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|367841
NZ_CP018870.1|WP_075970061.1|1693422_1694481_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl|CDD|182464
NZ_CP018870.1|WP_030030372.1|1690982_1691330_+|sterol-binding-protein	unknown	unknown	gnl|CDD|379708
NZ_CP018870.1|WP_075970062.1|1705188_1705830_-|DNA-3-methyladenine-glycosylase	unknown	unknown	gnl|CDD|376746
NZ_CP018870.1|WP_045324358.1|1694531_1695650_-|HAD-IIA-family-hydrolase	unknown	unknown	gnl|CDD|319832
NZ_CP018870.1|WP_030028994.1|1706840_1707377_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl|CDD|182339
NZ_CP018870.1|WP_030028988.1|1710558_1711353_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224044
NZ_CP018870.1|WP_075970060.1|1692379_1693426_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl|CDD|227119
NZ_CP018870.1|WP_030029114.1|1695737_1697009_+|DUF1015-domain-containing-protein	unknown	unknown	gnl|CDD|377633
NZ_CP018870.1|WP_030028989.1|1709997_1710426_-|NfeD-family-protein	unknown	unknown	gnl|CDD|224501
NZ_CP018870.1|WP_045321839.1|1690656_1690917_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030028991.1|1708068_1708839_-|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl|CDD|376667
NZ_CP018870.1|WP_030028995.1|1705938_1706721_+|sporulation-protein	unknown	unknown	gnl|CDD|369195
NZ_CP018870.1|WP_045324356.1|1711486_1712260_+|hypothetical-protein	unknown	unknown	gnl|CDD|273911
NZ_CP018870.1|WP_075970059.1|1689833_1690649_-|TlyA-family-RNA-methyltransferase	unknown	unknown	gnl|CDD|224110
NZ_CP018870.1|WP_030028990.1|1708928_1709915_-|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl|CDD|223407
NZ_CP018870.1|WP_030029118.1|1691543_1692362_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224045
NZ_CP018870.1|WP_107484754.1|1712690_1713677_-|beta-propeller-fold-lactonase-family-protein	unknown	unknown	gnl|CDD|274824
NZ_CP018870.1|WP_030030369.1|1688928_1689837_-|NAD-kinase	unknown	unknown	gnl|CDD|235121

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_030028992.1|1707527_1708031_+|HNH-endonuclease	gnl|CDD|224321	COG1403, McrA, Restriction endonuclease [Defense mechanisms].	2.78449e-15
NZ_CP018870.1|WP_079273422.1|1697082_1697850_-|tetratricopeptide-repeat-protein	gnl|CDD|367841	pfam04147, Nop14, Nop14-like family. Emg1 and Nop14 are novel proteins whose interaction is required for the maturation of the 18S rRNA and for 40S ribosome production.	0.000879694
NZ_CP018870.1|WP_075970061.1|1693422_1694481_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl|CDD|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	1.0779e-95
NZ_CP018870.1|WP_030030372.1|1690982_1691330_+|sterol-binding-protein	gnl|CDD|379708	pfam14864, Alkyl_sulf_C, Alkyl sulfatase C-terminal. This domain is found at the C-terminus of alkyl sulfatases. Together with the N-terminal catalytic domain, this domain forms a hydrophobic chute and may recruit hydrophobic substrates.	1.62527e-05
NZ_CP018870.1|WP_075970062.1|1705188_1705830_-|DNA-3-methyladenine-glycosylase	gnl|CDD|376746	pfam02245, Pur_DNA_glyco, Methylpurine-DNA glycosylase (MPG). Methylpurine-DNA glycosylase is a base excision-repair protein. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3-methyladenine and 3-methylguanine from damaged DNA.	2.6866e-85
NZ_CP018870.1|WP_045324358.1|1694531_1695650_-|HAD-IIA-family-hydrolase	gnl|CDD|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.21057e-97
NZ_CP018870.1|WP_030028994.1|1706840_1707377_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl|CDD|182339	PRK10257, PRK10257, putative kinase inhibitor protein; Provisional.	4.3341e-63
NZ_CP018870.1|WP_030028988.1|1710558_1711353_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.45066e-92
NZ_CP018870.1|WP_075970060.1|1692379_1693426_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl|CDD|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	8.27803e-105
NZ_CP018870.1|WP_030029114.1|1695737_1697009_+|DUF1015-domain-containing-protein	gnl|CDD|377633	pfam06245, DUF1015, Protein of unknown function (DUF1015). Family of proteins with unknown function found in archaea and bacteria.	6.11791e-121
NZ_CP018870.1|WP_030028989.1|1709997_1710426_-|NfeD-family-protein	gnl|CDD|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	2.74593e-16
NZ_CP018870.1|WP_030028991.1|1708068_1708839_-|sulfite-exporter-TauE/SafE-family-protein	gnl|CDD|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	8.08415e-24
NZ_CP018870.1|WP_030028995.1|1705938_1706721_+|sporulation-protein	gnl|CDD|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	4.45786e-107
NZ_CP018870.1|WP_045324356.1|1711486_1712260_+|hypothetical-protein	gnl|CDD|273911	TIGR01984, 2-polyprenyl-6-methoxyphenol_hydroxylase, 2-polyprenyl-6-methoxyphenol 4-hydroxylase. This model represents the FAD-dependent monoxygenase responsible for the second hydroxylation step in the aerobic ubiquinone bioynthetic pathway. The scope of this model is limited to the proteobacteria. This family is closely related to the UbiF hydroxylase which catalyzes the final hydroxylation step. The enzyme has also been named VisB due to a mutant VISible light sensitive phenotype. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	0.00489525
NZ_CP018870.1|WP_075970059.1|1689833_1690649_-|TlyA-family-RNA-methyltransferase	gnl|CDD|224110	COG1189, COG1189, Predicted rRNA methylase [Translation, ribosomal structure and biogenesis].	5.58139e-100
NZ_CP018870.1|WP_030028990.1|1708928_1709915_-|SPFH/Band-7/PHB-domain-protein	gnl|CDD|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	2.10319e-69
NZ_CP018870.1|WP_030029118.1|1691543_1692362_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	7.76647e-139
NZ_CP018870.1|WP_107484754.1|1712690_1713677_-|beta-propeller-fold-lactonase-family-protein	gnl|CDD|274824	TIGR03866, PQQ_ABC_repeats, PQQ-dependent catabolism-associated beta-propeller protein. Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.	5.08645e-48
NZ_CP018870.1|WP_030030369.1|1688928_1689837_-|NAD-kinase	gnl|CDD|235121	PRK03372, ppnK, inorganic polyphosphate/ATP-NAD kinase; Provisional.	2.99124e-170

Protein sequences

>NZ_CP018870.1|WP_079273422.1|1697082_1697850_-|tetratricopeptide-repeat-protein
MVARLIDEDPEQAYAYSRIALRLASRVAAVREAAGFAAYATQKYSEALAEFRAAKRMTGSVELWPVMADCERGLGRPERALAMAGEPEVQKLDKAGQVEMRLVAAGARRDQGQLEAAIVTLQSPELASNAVQPWTARLRYAYADALLAAGREDEAREWFGKALEADKDGATDASDRLAELDGVEFVDAAIDPSDDEDQDGIAHLADDEDADDEDAAEVAAAERAADVTEYYDEDDEEYEPLEQSAADAEGRGDKA
>NZ_CP018870.1|WP_030029114.1|1695737_1697009_+|DUF1015-domain-containing-protein
MTTSGTAEHGLRLIPFHGLRYVPERVGSLAAVTSPPYDVVVRPDGVDHLESADPHNIVRLILPQAGTPDARNEQAAHTLRDWLAEGVLSADPEPALYVYEQRRAGLLQRGVIGALALSAADAGIVLPHEDVMPDVVTDRAGLMRATSANLEPLLLTYRGDDPAAGAAAVVERTAQRTPLLSTTTEDGFQHRLWAITDPAELATVAGDLSHRQALIADGHHRWATYLRLQEEHGSPTAWDFGLVLLVDTARYPLQVRAIHRMLRRLPVADALAAVTGHFRVRPVDGPLPLALDALADAAERGNAFLLAGDGTFHLVTDPDLALLDRTVRHDRPEAWRRLDATVLHATLLDALWHVPDAPDQITYIHDAASTVEMAERHGGTAVLLHPVREEVVRDLARQGVTMPRKSTSFGPKPATGLVLRGLS
>NZ_CP018870.1|WP_045324358.1|1694531_1695650_-|HAD-IIA-family-hydrolase
MTRQIRTSPAACDQSLHQAYDTALLDLDGVVYAGGRAIGHAVESLAAARADGMHLAYVTNNALRTPEAVAEHLGELGIPTEAAEVITSAQAVARLIAEQVEPGSKVLVVGGEGLRVALRERGLVPVESADEQGLAAVVQGYGGPDLAWGRFAEAAYAINRGVPWFASNTDLTIPGARGIAPGNGAAVEVVRIATGADPQVAGKPLPPMHRETVLRTGAKRPLVVGDRLDTDIEGAFNGEVDSLLVLTGVTDAEQLLRAEPRHRPTYVDRDLRGLLSGQPEVVPAAEGFGCGGWTAVALNNGVLELREDAEDAEDAEEYVDRGESAGGAESGASGGGRDPMDGLRALCAAAWTAAAEGVCTLDAAKALARLGL
>NZ_CP018870.1|WP_075970061.1|1693422_1694481_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MLVESPPESGPSAAPPPDAVARPRHAARAAGLAGALVVLALIAVVSIAVGAKEMPLEEVRHGLFHYSGTTSDVVVRDLRVPRTLLGLMVGLGLGLSGAVMQALTRNPLAEPGILGVNAGAAAAVVSAISFLGASSLSEFVWWAFLGAAVVSVVVYVLGGSRSATPVRLALAGTAASAALVGYINAVQLMDSKALDKLRFWTVGSLASANMDTVRQVAPFLLVGAVLALALGRPLNAMAMGDDTARALGANLTRTRVGAMLAITLLCGAATAACGPIVFIGLMIPHLVRVFTGPDMRWVLAYSAVLSPVLLLGADVVGRVVTRPAELQVGIVTALIGGPVFIYLVRRKRMAQL
>NZ_CP018870.1|WP_075970060.1|1692379_1693426_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MTVTAKARPVRLPGSVSLRIERRALAVGVLLVLAAFVMAVLLIGTGDFDIAPWDVVQTLLGNGTPANDFIVNDLRLPRVLVALLVGAALGMAGAVFQSVTRNPLGSPDLLGFSYGSAVGALVVIVLMNGSATEVAVGALIGGLLAGAAVYLLAYKRGIHGYRLVLVGIGASAMLVAVIQYLLTKAQLVEASRAMVWLTGSLAGRDWAQVWPLLLTCAVLFPLVLGQSRALRMIEMGDDAAYAVGVRVERTRLLLMLAAILLTTAASAAAGPISFVALAAPQLARRLTRSPGANLLTGALMGSVVLLLSDWASQRAFGADQLPVGVVTGLVGGVYLLWLLVTERKAGRI
>NZ_CP018870.1|WP_030029118.1|1691543_1692362_-|ABC-transporter-ATP-binding-protein
MQRLTAENVTLGYDQRVIAENLSVEIPDNSFTVIVGPNACGKSTLLRALSRMLKPSRGRVLLDGQAIGSMPAKKVAKTLGLLPQSSIAPDGITVADLVSRGRYPHQGLLRQWSPEDERIVNESMASTGVAELADRAVDELSGGQRQRVWIAMALAQQTPLLLLDEPTTYLDIQHQIDVLDLCAELHETQGRTLVAVLHDLNHAARYATHLIAMRGGEVVAEGPPREVVTAELVEKVFGLRCQVIDDPETGTPLVIPAARRSRTQAAAEAGAL
>NZ_CP018870.1|WP_030030372.1|1690982_1691330_+|sterol-binding-protein
MATIQECREALDRLSDNLARAEAGVRGAAAFDRSLSCHITDLDQTFTGRLDGGRIRVDAVAAGPPAQKAEIRLAMTGDDLVALVAGELKFAKAWASGRVRLEAGFRDLLRLKSLL
>NZ_CP018870.1|WP_045321839.1|1690656_1690917_-|hypothetical-protein
MTDEAAETRAEAPAEPAGPSGPVPLGVVRTPTGHTGVDAHLARLADADHLGADGHLGVYEDVHRGLREALTALDAPPVPGPYENRS
>NZ_CP018870.1|WP_075970059.1|1689833_1690649_-|TlyA-family-RNA-methyltransferase
MAGVARRRLDAELVRRSMARSREHAAQLIAAGRVTVGGTTATKAATQVETSAALVVLKDDADPDYVSRGGHKLAGALAAFQPQGLRVEGRRALDAGASTGGFTDVLLRAGAAHVMAVDVGYGQLAWSLQSDDRVTVKDRTNVRELTVEQIDGVPVDLVVGDLSFISIGLVLPALVRCTAPDADLVLMVKPQFEVGKDRLGGGGVVRSPELRAEAVRGVAAQAAGLGLGVLGVTASPLPGPSGNVEYFLWLRAGAPALDPADVDRAVAEGPQ
>NZ_CP018870.1|WP_030030369.1|1688928_1689837_-|NAD-kinase
MTDFPGERTVFLLAHTGRPAAIRSAELVVKGLLRCGLGVRVFAHEAVDLPLPPEVELVTESTPGVLDGCELLVVLGGDGTLLRGAEFARASGVPMLGVNLGRVGFLAEAERDDLDKVVDRVVTRAYEVEERMTLDVIVRTNGDVVHRDWALNEAAVQKVSPERMLEVVLEIDGRPVTGFGCDGIVCATPTGSTAYAFSAGGPVVWPEVEALLMVPISAHALFAKPLVTSPNSVLAVEVQNGTPHGVLWCDGRRTLELPAGARVEVRRGAVPVRLARLHHASFTDRLVAKFALPVSGWRGAPH
>NZ_CP018870.1|WP_075970062.1|1705188_1705830_-|DNA-3-methyladenine-glycosylase
MSARLDRTPLSRSFFDRPVLTVAPDLLGRTLVRNTEEGPLELRITEVEAYEGESDPGSHAYRGRTARNASMFGPPGHAYVYFIYGMWFSLNLVCGPPGHASGVLLRAGEITTGADLAAKRRVSARRPSELAKGPARLATALDVDRSLDGTDLCGGPDSPLSVLTGTPTWPDLVSSGPRTGVGGAGADHPYRFWITHDPTVSPYRAHAPRRRST
>NZ_CP018870.1|WP_030028995.1|1705938_1706721_+|sporulation-protein
MGFKKLFASLGAGGASVDTIITEPNVVPGGIVQGEVRLQGGSVEQQIEGLSVGLQARVEVEGGDQEYKQDVVFTKQRLGGAFQVQAGALHVVPFALEIPWETPITHFAGQHLHGMNIGVSTELEIARAVDAGDLDAINVHPVPAQQAILDAFRQLGFTFRSADMERGHIRGTRQTLPFYQEIEFLPPSQYRGLHQVELTFVSDGREMDVVLEMDKKPGLFSEGSDTYRCFQVGLQSYQDTDWAAYLNQWIASVGSQRNWF
>NZ_CP018870.1|WP_030028994.1|1706840_1707377_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MSEQSRAPLPHDFHPEVASFTVTSEDVSHGEDLHAAQVLTGKNVSPHLRWEGFPEGTKSFAVTCFDPDAPTGSGFWHWVLFDLPASVTELPAGAGTGDFTGLPEGAVHARNDYGTRDFGGAAPPRGERHRYVFTVYAVDREQLGPDEDSSPAVVGFHLRFHALGRAQLVAEYEAPAAR
>NZ_CP018870.1|WP_030028992.1|1707527_1708031_+|HNH-endonuclease
MRDTLVLNASFEPLSTVTLNRAVVLVLQDKAVVEQSHPDLRVRAATMELPMPRVIRLCRYVRVPFRRHAPWSRRGVLVRDQHRCAYCGKRATTVDHVLPRAQGGGDTWLNTVASCAEDNHRKAARTPEEAGMPLLRKPFVPSPADAMLLALGVAGQDALPEWLERSA
>NZ_CP018870.1|WP_030028991.1|1708068_1708839_-|sulfite-exporter-TauE/SafE-family-protein
MSIWEALAVFAAGIGAGTINTIVGSGTLITFPVLLATGLPPVTANVSNTLGLVPGSISGAIGYRKELQGQRARVLRLGAVSAVGGLAGAALLLALPSDSFDTIVPVLIGLALVLVILQPRLAAALRRRQEAAGGDTGHPDGGPVLLGGMLFSSAYGGYFGAAQGVLYLGLMGLLLRDDLQRINAVKNVIAALVNGIAAVFFLFVAEFDWTAVLLIAVGSTIGGQIGAKVGRRLPPTVLRGVIVTVGTLAIVQLLLR
>NZ_CP018870.1|WP_030028990.1|1708928_1709915_-|SPFH/Band-7/PHB-domain-protein
MQPIIIVLIILVVLVFIALVKTIQVIPQASAAIVERFGRYTRTLNAGLNIVVPFIDSIRNRIDLREQVVPFPPQPVITQDNLVVNIDTVIYYQVTDARAATYEVASYIQAIEQLTVTTLRNIIGGMDLERTLTSREEINAALRGVLDEATGKWGIRVNRVELKAIEPPTSIQDSMEKQMRADRDKRAAILQAEGVRQSEILRAEGEKQSSILRAEGEAKAAALKAEGEAQAIRTVFESIHAGDADQKLLAYQYLQMLPKIAEGDANKLWIVPSEIGDALKGLSGAMGNFGPLGGGSGFNPQNSGKDGGGIPAARDKDSADRREQPPID
>NZ_CP018870.1|WP_030028989.1|1709997_1710426_-|NfeD-family-protein
MDIDAWVWWLIGAVGLGIPLVLTAMPEFGMFAVGAVAAAVTAALGGGVVAQVLVFTVVSVALIAVVRPIANRHRDQRPQHRSGIDALKGRSAVVLERVDGTGGRIKLAGEVWSARALDADTSFEPGRSVDVVEIDGATAIVM
>NZ_CP018870.1|WP_030028988.1|1710558_1711353_-|ABC-transporter-ATP-binding-protein
MSDVLELVDVSVVREGRALVDQVSWSVKEGERWVILGPNGAGKTTLLNLASSYLFPTKGSATILGSTLGKVDVFELRPRIGMAGIAMADKLPKRQTVLQTVLTAAYGMTATWQEEYEAVDEQRARAFLDRLGMTEYLDRKFGTLSEGERKRTLIARALMTDPELLLLDEPAAGLDLGGREDLVRRLGRLARDPLAPSMVMVTHHVEEIAPGFTHVLMIRQGKVVTAGPIDLELTSRNLSLCFGLPLVVERNGTDRWTAQGLPLG
>NZ_CP018870.1|WP_045324356.1|1711486_1712260_+|hypothetical-protein
MLFEPRSGRLAAWGNALLAGLVSPDEAAMSIVGEDAVHRVAGLPGEAGPVGLTLALGRLRALGVSGLRVALPAPGHPLGLSGPPEFNARALEAEEAVVAVGAALGLVPEVAEAGPAGDVHVSVTWHVLPVREAPPADVPSLGEAERELAEALREATGVLTRLDVAGSGPVAEAALSAYRARAEAGRDTLAPGYPARAVRVLALAQRVDLMVSLAYESGHGGAVAASEMAARAEALRPVERVARRALVAAYNSAVEQH
>NZ_CP018870.1|WP_107484754.1|1712690_1713677_-|beta-propeller-fold-lactonase-family-protein
MTRNSDIARRTAAVLCATAALTGLSAAPPERPGPVVHVANLHSDTVSVVDIRTGAVVDDIPVGDGPDSVAVSPDGARLYVTDSGADTVSVIDTRTRTVVDTITVGREPSRATVSPDNERVYVANVGADTVSVISTRTGTVTDTIAVGDAPLGLAVTPDGRTLYVANAGSDSVSVVRTDSGTVTGAVPVGAGPTALALAPDCRHLYVSNLTSDDVSVVDIREGAETARVPVGDQPAGIGVRPDGRRVYVADIGSDTVSVIDTRRHTVTDTIPVGDGPNGLAVDPDGSRVYVSNFDSDTLTVIDTETATPTATVPVGDGPTGVATQPAPR

Crispr_ID: NZ_CP018870_4

• CRISPR_ID: NZ_CP018870_4
• CRISPR_location: 1835864-1835933
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_4

Consensus_repeat	Method
CGCGCCGGTCGCCCCGGTCACCCCG	CRISPRCasFinder

spacers of NZ_CP018870_4

>4.1|1835889|20|NZ_CP018870|CRISPRCasFinder
GTCACCCCGTCCGCGCCGGT

CRISPR arrays and Neighbor proteins around NZ_CP018870_4

CRISPR arrays

The CRISPR arrays of NZ_CP018870_4

>merge|NZ_CP018870|4|1835864-1835933|CRISPRCasFinder
CGGCCCGTCCGCGCCGGTCGCCCCGGTCACCCCGTCCGCGCCGGTCGCCTGGGTCACGCCGGTCGCGCCG

>NZ_CP018870|4|3|1835864-1835933|CRISPRCasFinder
CGGCCCGTCCGCGCCGGTCGCCCCG	GTCACCCCGTCCGCGCCGGT
CGCCTGGGTCACGCCGGTCGCGCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_030009075.1|1832305_1833301_-|DNA-binding-protein-WhiA	unknown	unknown	gnl|CDD|273194
NZ_CP018870.1|WP_045321580.1|1840844_1841726_+|carbohydrate-kinase	unknown	unknown	gnl|CDD|238572
NZ_CP018870.1|WP_045321578.1|1846594_1847920_+|MHS-family-MFS-transporter	unknown	unknown	gnl|CDD|340927
NZ_CP018870.1|WP_075970098.1|1840323_1840755_-|Rieske-(2Fe-2S)-protein	unknown	unknown	gnl|CDD|239550
NZ_CP018870.1|WP_030030532.1|1845742_1846399_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293792
NZ_CP018870.1|WP_045321579.1|1845029_1845719_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl|CDD|236578
NZ_CP018870.1|WP_075970097.1|1839290_1840205_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030026858.1|1834352_1835300_-|RNase-adapter-RapZ	unknown	unknown	gnl|CDD|235450
NZ_CP018870.1|WP_075970095.1|1826585_1827797_-|phosphoglycerate-kinase	unknown	unknown	gnl|CDD|234613
NZ_CP018870.1|WP_030026864.1|1825442_1825673_-|preprotein-translocase-subunit-SecG	unknown	unknown	gnl|CDD|235881
NZ_CP018870.1|WP_075970096.1|1829161_1832155_-|zinc-carboxypeptidase	unknown	unknown	gnl|CDD|349432
NZ_CP018870.1|WP_030030609.1|1841862_1844844_-|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl|CDD|234734
NZ_CP018870.1|WP_030032687.1|1838430_1839033_-|hypothetical-protein	unknown	unknown	gnl|CDD|372083
NZ_CP018870.1|WP_030026863.1|1825803_1826580_-|triose-phosphate-isomerase	unknown	unknown	gnl|CDD|234589
NZ_CP018870.1|WP_075972016.1|1823120_1824776_-|glucose-6-phosphate-isomerase	unknown	unknown	gnl|CDD|234679
NZ_CP018870.1|WP_030026859.1|1833291_1834356_-|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK	unknown	unknown	gnl|CDD|211689
NZ_CP018870.1|WP_010352468.1|1824926_1825262_-|RNA-polymerase-binding-protein-RbpA	unknown	unknown	gnl|CDD|379162
NZ_CP018870.1|WP_030026861.1|1827923_1828928_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|223135
NZ_CP018870.1|WP_045321603.1|1847972_1848956_-|TerC-family-protein	unknown	unknown	gnl|CDD|274743
NZ_CP018870.1|WP_107484896.1|1837579_1838542_-|hypothetical-protein	unknown	unknown	gnl|CDD|235904

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_030009075.1|1832305_1833301_-|DNA-binding-protein-WhiA	gnl|CDD|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	1.10412e-139
NZ_CP018870.1|WP_045321580.1|1840844_1841726_+|carbohydrate-kinase	gnl|CDD|238572	cd01167, bac_FRK, Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.	9.10568e-77
NZ_CP018870.1|WP_045321578.1|1846594_1847920_+|MHS-family-MFS-transporter	gnl|CDD|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.27568e-160
NZ_CP018870.1|WP_030030532.1|1845742_1846399_+|MBL-fold-metallo-hydrolase	gnl|CDD|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	2.93147e-39
NZ_CP018870.1|WP_045321579.1|1845029_1845719_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl|CDD|236578	PRK09583, PRK09583, mycothiol-dependent maleylpyruvate isomerase; Reviewed.	4.25021e-73
NZ_CP018870.1|WP_075970098.1|1840323_1840755_-|Rieske-(2Fe-2S)-protein	gnl|CDD|239550	cd03467, Rieske, Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. The Rieske domain can be divided into two subdomains, with an incomplete six-stranded, antiparallel beta-barrel at one end, and an iron-sulfur cluster binding subdomain at the other. The Rieske iron-sulfur center contains a [2Fe-2S] cluster, which is involved in electron transfer, and is liganded to two histidine and two cysteine residues present in conserved sequences called Rieske motifs. In RO systems, the N-terminal Rieske domain of the alpha subunit acts as an electron shuttle that accepts electrons from a reductase or ferredoxin component and transfers them to the mononuclear iron in the alpha subunit C-terminal domain to be used for catalysis.	2.72935e-24
NZ_CP018870.1|WP_030026858.1|1834352_1835300_-|RNase-adapter-RapZ	gnl|CDD|235450	PRK05416, PRK05416, RNase adapter RapZ.	2.23684e-166
NZ_CP018870.1|WP_075970095.1|1826585_1827797_-|phosphoglycerate-kinase	gnl|CDD|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NZ_CP018870.1|WP_030026864.1|1825442_1825673_-|preprotein-translocase-subunit-SecG	gnl|CDD|235881	PRK06870, secG, preprotein translocase subunit SecG; Reviewed.	6.96112e-13
NZ_CP018870.1|WP_075970096.1|1829161_1832155_-|zinc-carboxypeptidase	gnl|CDD|349432	cd03859, M14_CPT, Peptidase M14 Carboxypeptidase T subfamily. Peptidase M14-like domain of carboxypeptidase (CP) T (CPT), CPT belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. CPT has moderate similarity to CPA and CPB, and exhibits dual-substrate specificity by cleaving C-terminal hydrophobic amino acid residues like CPA and C-terminal positively charged residues like CPB. CPA and CPB are M14 family peptidases but do not belong to this CPT group. The substrate specificity difference between CPT and CPA and CPB is ascribed to a few amino acid substitutions at the substrate-binding pocket while the spatial organization of the binding site remains the same as in all Zn-CPs. CPT has increased thermal stability in presence of Ca2+ ions, and two disulfide bridges which give an additional stabilization factor.	1.10745e-112
NZ_CP018870.1|WP_030030609.1|1841862_1844844_-|excinuclease-ABC-subunit-UvrA	gnl|CDD|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_CP018870.1|WP_030032687.1|1838430_1839033_-|hypothetical-protein	gnl|CDD|372083	pfam12385, Peptidase_C70, Papain-like cysteine protease AvrRpt2. This is a family of cysteine proteases, found in actinobacteria, protobacteria and firmicutes. Papain-like cysteine proteases play a crucial role in plant-pathogen/pest interactions. On entering the host they act on non-self substrates, thereby manipulating the host to evade proteolysis. AvrRpt2 from Pseudomonas syringae pv. tomato DC3000 triggers resistance to P. syringae-2-dependent defense responses, including hypersensitive cell death, by cleaving the Arabidopsis RIN4 protein which is monitored by the cognate resistance protein RPS2.	1.37255e-10
NZ_CP018870.1|WP_030026863.1|1825803_1826580_-|triose-phosphate-isomerase	gnl|CDD|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	2.88088e-145
NZ_CP018870.1|WP_075972016.1|1823120_1824776_-|glucose-6-phosphate-isomerase	gnl|CDD|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0
NZ_CP018870.1|WP_030026859.1|1833291_1834356_-|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK	gnl|CDD|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	3.16067e-97
NZ_CP018870.1|WP_010352468.1|1824926_1825262_-|RNA-polymerase-binding-protein-RbpA	gnl|CDD|379162	pfam13397, RbpA, RNA polymerase-binding protein. RbpA is a family bacterial RNA polymerase-binding proteins. RbpA acts as a transcription factor by binding to the sigma subunit of RNA polymerase.	2.59116e-58
NZ_CP018870.1|WP_030026861.1|1827923_1828928_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl|CDD|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	0
NZ_CP018870.1|WP_045321603.1|1847972_1848956_-|TerC-family-protein	gnl|CDD|274743	TIGR03718, R_switched_Alx, integral membrane protein, TerC family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains TerC itself from Alcaligenes sp. plasmid IncHI2 pMER610 and from Proteus mirabilis. It also contains the alkaline-inducible E. coli protein Alx, which unlike the two TerC examples is preceded by a yybP-ykoY leader.	5.04332e-138
NZ_CP018870.1|WP_107484896.1|1837579_1838542_-|hypothetical-protein	gnl|CDD|235904	PRK06995, flhF, flagellar biosynthesis protein FlhF.	0.00105837

Protein sequences

>NZ_CP018870.1|WP_030026858.1|1834352_1835300_-|RNase-adapter-RapZ
MTEHETTHDRDGAQVSTGTTAEPGETAEAAIPELVIISGMSGAGRSTAAKCLEDLGWFVVDNLPPALIPTMVELGARSQGNVARIAVVVDVRGRQFFDALRESLADLDSKGVTRRIVFLESSDDALVRRFESVRRPHPLQGDGRITDGIAAERDLLRELRGDADLVIDTSSLNVHELRAKMDAQFAGDEEPELRATVMSFGFKYGLPVDADLVVDCRFIPNPHWVPELRPFTGLNEEVSGYVFSQPGAKEFLDRYTELLQLIATGYRREGKRYVTIAVGCTGGKHRSVAMSEKLAARLASEGVETVVVHRDMGRE
>NZ_CP018870.1|WP_030026859.1|1833291_1834356_-|uridine-diphosphate-N-acetylglucosamine-binding-protein-YvcK
MTARTPRLSRLRRLTPGRGEDGAGRSGRSGRRRGTTPKVVALGGGQGLSASLAALRRITGDLTAVVTVADDGGSSGRLREELGVLPPGDLRKALAALCGDDDWGQTWARVIQHRFQSEGDLHGHAVGNLLIVALWEQLGDPVQALDLVGRLLGAHGRVLPMSAVPLELQALVRGHDPARPEDVDTVRGQATVALTPGEVLSVQVVPSAPPAVPEAVAAVLDADWVVLGPGSWFSSVIPHLLVPELLDALTETKARRVLSLNLAPQPGETEGFSPQRHLEVLARHAPKLALDVVLADEAAVPDRESLADAAKRFGAAVELAPVARQDGSPKHDPELLAAAYDRIFRMHGRIGPWR
>NZ_CP018870.1|WP_030009075.1|1832305_1833301_-|DNA-binding-protein-WhiA
MAMTPAVKDEISRLPVTRTCCRKAEVSAILRFAGGLHLVSGRIVIEAELDTGIAARRLRKDILEIFGHSSDLVVMAPGGLRRGSRYVVRVVAGGDQLARQTGLVDGRGRPIRGLPPQVVSGATCDAEAAWRGAFLAHGSLTEPGRSSSLEVTCPGPEAALALVGAARRLSIAAKAREVRGVDRVVVRDGDAIGALLTRLGAHESVLAWEERRMRREVRATANRLANFDDANLRRSARAAVAAGARVQRALEILGEEVPEHLAAAGRLRMEHKQASLEELGALADPPLTKDAVAGRIRRLLAMADKRAQDLGIPGTESNLDLSEEMADNMAG
>NZ_CP018870.1|WP_075970096.1|1829161_1832155_-|zinc-carboxypeptidase
MSHRARVVLAASALVLGTTLAALPATAQARPGPAPGTASPGPAPGPASGAEEVRVYDADITREQVPLVLAAGQDAHELSERAPDAGTARVELFLTGAQAGELAAQGVKLAERVVPAQGLARAKAAGDGVFRPYSGKGGLQEEILRTAREHPALTKVVSIGKTVQGKDILALKVSKNAKKTKDGHKPSVLYMSNQHAREWITPEMTRRLMHHTLDNYGKDQRITGLVDSSELWFLLSANPDGYDYTHAPDGRRLWRKNLRDNNGDGTVTAGDGVDLNRNFAYKWGYDNEGSSPNQASETYRGPKASSEPETAALDAFQKRIGFEYAVNYHSAAELLLYGVGWQVATPTPDDVAYKTLAGTPENPGVPGYHPQVSSELYTTNGEADGHASNVNGIMMFTPEMTTCQTASAADPDDPWKPEDCASGFNFPDDEKLIQAEFAKNVPFALAVGESAAHPDRPSSPVGLSAPDFTLDPFTTSYAARGQDQQVAVTARKSLKDKELNYRINGGRTHDEDLKAWKGGDVYGGEDNNWFDEYRAEVEGTKPGDEVEVWFTGRDRSGRRVSSEHFTYTVAERPRADVLVIAEEGAAAQHAQTYVDALRANGRSAAVWDVAVQGVPHHLGVLSHFATAVHHTGAKTPGGDTQLAVRDFLNEGGRLIEAGEQAGGNAQVGPALTNDFSQYWLGAYGRTSTPGATGFTGAGALHGANGGLGDAAGNPLNTPGSYTVTSETLAPAQFPQFTSAQAGGYTGIKNPYAPYAGGQMASALHADSDWKRLVRTIDLTGVTAADRPQLRLALNWNLENGYDHAALEARSAGGDDWTMLPEAGGLSSPAVPEECAAGFFVNGHPFLRRYLTLEGGGCTPHGTSGQWNTFTGSSGGWKQVSFDLSAYAGRSVELSLSTITDPGTGGRGVFADEVRLSTAAGEQPAEGFETSLGAWTAQGAPAGSPDVPGDWARTGELFRSYASVTTRDTVLLGFGLEHLPAAADRALLVGKALRTLNR
>NZ_CP018870.1|WP_030026861.1|1827923_1828928_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MTIRVGINGFGRIGRNYFRALLEQGADIEIVGVNDLTDNATLVHLLKYDTILGRLKAEVSHTDDTITVGGNTFKTFAERDPANLPWGELGADIVIESTGIFTKKADAAKHIAAGAKKVLISAPAKDEDITIVMGVNQDKYDAANHHVISNASCTTNCVAPMAKVLDENFGIVKGMMTTVHAYTNDQRILDFPHSDLRRARAAAENIIPTSTGAAKATALVLPQLKGKLDGIAMRVPVPTGSVTDLVLELDREVTKDEINAAFQKASEGQLKGILDYTEDAIVSSDIVNWPASCTFDSSLTMVQGKQVKVVGWYDNEWGYSNRLVDLTVFVGGRL
>NZ_CP018870.1|WP_075970095.1|1826585_1827797_-|phosphoglycerate-kinase
MKTIDELLAEGVKGKRVFVRADLNVPLAEGTITDDGRIRAVQPTIAKLAEAGARVVVASHLGRPKGAPEAAFSLAPAAVRLGELLGADVAFATDTVGSSAKETVAALTDGQVAVIENLRFNAGETSKDDAERAAFADQLAGLADIYVGDGFGAVHRKHASVFDLPARLPHAAGQLIATEVGVLKKLTDEVKRPYVVVLGGAKVSDKLAVIDELLGKADRILIGGGMAYTFLYAKGHEVGISLLQKDQVDKVKEYMARAESTGVELVLPVDILAASDFPDLKTKAPAEYTTVDADKIPADKEGLDIGPKTRELYASKIADAETVFWNGPLGVFEHPDYAGGTRAIAQALVDSDAFTVVGGGDSAAAVRTLGFDENAFGHISTGGGASLEYLEGKTLPGLAALEG
>NZ_CP018870.1|WP_030026863.1|1825803_1826580_-|triose-phosphate-isomerase
MTTRTPLMAGNWKMNLNHLEAIAHVQKLAFALADKDYDAVEVAVLPPFVDLRSVHTLVEGDKLKIKYGAQDVSAHDSGAYTGEISGSMLAKLKCTFVAVGHSERRQYHGESDEVCNAKVKAAYRHGLTPILCVGEGLDVRKAGNQVAHTLAQVDGGLKDIPAEQAESIVIAYEPVWAIGTGEVATPEDAQEVCGAIRRRLAELYSQELADKVRIQYGGSVKSGNIAAIMAQPDVDGALIGGAALDADEFVKIVRFRDQ
>NZ_CP018870.1|WP_030026864.1|1825442_1825673_-|preprotein-translocase-subunit-SecG
MGFSIALIVFSALLMLLVLMHKGKGGGLSDMFGGGMQSSVGGSSVAERNLDRITVVVGLLWFACIVALGLVVKSTS
>NZ_CP018870.1|WP_010352468.1|1824926_1825262_-|RNA-polymerase-binding-protein-RbpA
MASGNAIRGSRVGAGPMGEAERGESAPRLRISFWCSNGHETQPSFASDAQVPDTWDCPRCGFPAGQDRDNPPAPPRTEPYKTHLAYVRERRSDADGEAILAEALAKLRGEI
>NZ_CP018870.1|WP_075972016.1|1823120_1824776_-|glucose-6-phosphate-isomerase
MNAESRAKLNRMPEWLALGKHREEFGHTHLRQLFEENPGRGAGYTLQVGDLHIDYSKHLVTDETLELLRELAAATGVAELREAMFRGEKINTTEDRAVLHTALRAPADTVVEVDGEDVVPGVHAVLDKMAAFSEQIRSGKWTGFTGQRIRNVVNIGIGGSDLGPAMAYEALRAFTDRGLTVRFVSNVDGADLHEAVRDLDPAETLFIIASKTFTTIETITNATSARGWLLAGLGGDQAAVARHFVALSTNAEKVTEFGIDPANMFEFWDWVGGRYSFDSAIGLSLMIAIGPGAFRDLLAGFHLMDQHFRTAPAEENAPLLMGLLGIWYGAFFDAQSHAVLPYSHYLSRFTAYLQQLDMESNGKSVDRDGDPVQWQTGPVVWGTPGTNGQHAYYQLIHQGTKVIPADFIGFANPVAELEAAPAAQHDLLMANFFAQTQALAFGKTADEVRAEGAPESLVPHKTFHGNHPTTTILATELTPGVLGQLIALYEHKVFVQGAVWNIDSFDQWGVELGKVLAKRVEPALTEGVDVPGLDASTQSLVTTYRKLRGRA
>NZ_CP018870.1|WP_107484896.1|1837579_1838542_-|hypothetical-protein
MGRPLALQRPLQLGLARLVCQQQHLLLDPLPLPDRGVSAMTLRASAAAAVLAATALLGLAPQAVAAPVPQPVSPPEPQLVSPPAPQPEAATAEHRAAAGQAAAAPETLATLSRFFAREGRVSLAAARPRIEGEAIAVNHLSPDFVAGRPGAAVARLEFLASRAVSSDGQRAALWTARTEQGWQVVNIATGDDEFRYAGLGAAKLPGGTVFREPQIDAWYVAGGGRVLPLDEDGVRAVGAGGTTLSAYRVRVAEAYGDKLPGSPYAERGAAGGFAEGGGAGAGGAERGRGAGPGGLLAGAGALALGAAVVPLLRRRRVATA
>NZ_CP018870.1|WP_030032687.1|1838430_1839033_-|hypothetical-protein
MRDRNRRLSPAAVLTALLSALILALPAGTATAAEAGTDSALAYKRLNITMQAQAKTNWCWAAGGNTIAAWFGRNHSQNQFCNAAFNRPQGTECPNNQATLGNVQTGLRWAGINPGSYVTGWLQYSTVQTEINAGRPIETRIQWSNGGGHMHVVYGYDTANSWVYWGDPWPSSDRYNWASHAWYVNNNTFSWTHSLYRIGA
>NZ_CP018870.1|WP_075970097.1|1839290_1840205_+|hypothetical-protein
MAELDRLLRGGPFHLALRAALAARGLPLQRVQHRLAAQGIKVGVTSLSYWQQGARRPRHPESLRAVTALERILELPDGSLVRLLAVPGPGAGQDRPAGRSYRALFSGGGTVERLLDGMELPPDGGLHSLGHHERVRIGPAGELRIRESQQIVRAHRDGVDRYLAVHHGDPGCDVSRVRVTAYENCRTGRVRGHPEAGVVVAELLFDARLRRGDTYVFGYGVEDGTGARSGEYVRGFSYAGGQYVLQVRFDEAALPVRCRRFTRSGPDAPRTGLADLTPSGRHRAVHLVEQSVRRGILGIAWDWD
>NZ_CP018870.1|WP_075970098.1|1840323_1840755_-|Rieske-(2Fe-2S)-protein
MSAPQSAARRTVLKGAAALAGAAGAGAALTACSTETNSGGNTPATPTAPVELGAAADVPVGGAKLYRERKLVVSCPAEGQYKAFSAQCTHAGCVLDKIDDGEGNCPCHGSRFDVATGKVLRGPADRPLPEVPVRAENGRLVAG
>NZ_CP018870.1|WP_045321580.1|1840844_1841726_+|carbohydrate-kinase
MIVVGGEALIDLVPAAGPPGALLPRPGGGPYNTARALGRLGAEVAFCSRVSADGFGESLLAGLRAAGVDVSLVQRGPEPTTLAVPSLAPDGSASYGFYVEGTADRLFTLPPALPEGVRALALGTCSLVLEPGASAYEALLRRESRRGLLTLLDPNIRPALIADPAGYRARFGERLLPHTGVLKLSEEDAAWLGGRVGDWLAAGPWAVVVTRGPAGLTVFTREGAEYSAAARPVAVADTIGAGDTVNAALLHRLAAAPGGPVDWPDVLAYAAHAAALTCTRPGAEPPYAAELNG
>NZ_CP018870.1|WP_030030609.1|1841862_1844844_-|excinuclease-ABC-subunit-UvrA
MTDRLIVRGAREHNLKNVSLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSSYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITEVYDYLRLLFARIGKPHCPECRRPISRQSPQAIVDKVLALPEGSRFQVLSPLVRERKGEFVDLFADLQTKGYSRARVDGETIQLSEPPTLKKQEKHTIEVVVDRLTVKDSAKRRLTDSVETALGLSGGMVILDFVDLAEDDPERERMYSEHLYCPYDDLSFEELEPRSFSFNSPFGACPECTGIGTRMEVDPELIVPDEEKSLDEGAVSPWSLGHTKDYFQRLIGALAGELGFRTDIPWAGLPVRAKKALLYGHRTQIEVRYRNRYGRERAYTTAFEGAVPFVKRRHAESESDASRERFEGYMREVPCPTCEGTRLKPIVLAVTVMEKSIAEVAAMSISECADFLGRMRLDARDKKIAERVLKEVNERLRFLVDVGLDYLSLNRAAGTLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNHRLIETLVRLRDMGNTLIVVEHDEDTIKVADWVVDIGPGAGEHGGKVVHSGSLKELLKNTESMTGQYLSGKKSIEIPDIRRPVNGERKLTVHGAKENNLRDIDVSFPLGVLTAVTGVSGSGKSTLVNDILYTHLARELNGARSVPGRHTRVEGDDLVDKVVHVDQSPIGRTPRSNPATYTGVFDHVRRLFAETMEAKVRGYLPGRFSFNVKGGRCENCSGDGTIKIEMNFLPDVYVPCEVCHGDRYNRETLEVHYKGKSIAEVLNMPIEEALDFFEAVPTIARHLKTLNEVGLGYVRLGQSAPTLSGGEAQRVKLASELQKRSTGRTVYVLDEPTTGLHFEDISKLIKVLSGLVDKGNSVIVIEHNLDVIKTADWVIDMGPEGGYGGGLVVAEGTPEQVASVGASHTGKFLRDILGADRVSDAGASPVRAAAKKAPARKATAAKKAAPAKKTAAKKTATRARKA
>NZ_CP018870.1|WP_045321579.1|1845029_1845719_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MTDHVHDLRSVREATDRLLTAVAKLDNGALSEESHLPGWTRGHILAHLARNADALLNVLEGRPMYESGEARDADIARDAGRPLVEHLADLRDSADRFLAATEHAQDWSRTVELRGGVTDLAANVPFRRWVEVDLHHVDLNIGYELSDLPEEFTDREITFLADRWSGRPEVPATALAAADGRGWRTGSAGDPAVTVSGSPAALLAWLAGRGDKGASLTTTGGPLPELPPL
>NZ_CP018870.1|WP_030030532.1|1845742_1846399_+|MBL-fold-metallo-hydrolase
MTYTGEVKVGGPADVHELADLMISKVAVGSMNNNAYLLRCRATDEQLLIDAAAEPQTLLNLIGDDGIASVVTTHRHGDHWGALAEVVAATGARTYAGALDAEGIPVATDVPVADGDTVRVGRVELTARHLVGHTPGSIALVYDDPHGHAHVFTGDCLFPGGVGNTHDDPEAFKSLLDDVQHKLFEQLPDETWVYPGHGNDTTLGAERPHLAEWRERGW
>NZ_CP018870.1|WP_045321578.1|1846594_1847920_+|MHS-family-MFS-transporter
MLRLASAALAGTAIEFYDFFVYGTAAALVLGPLFFPSFSPLAGTLAAFGTFGVGFLARPLGSALFGHIGDRYGRRPVLLASLLLTGIATVAVGCVPTYGTIGIAAPVLLLLLRFLQGLGLGGEWGGAVLLTAEHAPERRRGLWASFPQIGPAVGFLLANGLMLGLSAALTDAQFTSWGWRVPFWAAGLLALAGLWLRRSVEETPQFRELAAAGRRADAPLAEVLRGHWRLLLLTGGALAVGYAVFYAVTTWSLAYATEHLSVSRTTMLACIMAAVAFKGLMTPLMAVLGDRYGRRPLCLAGCAASAVWMFPLVALMRTADPLLMTLGFAVALLGMVTMFSVVGAYLPELYAPRIRCTGAAVGYNLGGVLGGALTPIVATALADGSGPPWGVAAYLTGIALVSLACFALLPETSPLVVRKRSGAPDEAKETETGAARTAAPV
>NZ_CP018870.1|WP_045321603.1|1847972_1848956_-|TerC-family-protein
MEVSWALWAATVLGLSLLIAVDFLIGRKPHDVSIKEAGTWTVVWIVLAALFGLGLWFFGTPQASQEFFAGFITEKSLSVDNLFVFVLIMAKFAVPSHLQQRVLLVGVLIALVLRAVFIAAGAAIIASFSWVFYIFGAFLIYTAWKLIQEARKDEDEDEFEENRLLKSVEKKFGVADRYHGTKLFIVNNGKRVLTPLMIVMLAIGTTDVLFALDSIPAIFGLTQDPYIVFTANAFALMGLRQLYFLIGGLLEKLVHLSYGLSIILGFIGVKLVLHALHESGVHVPEISIPLSLGVICGVLVITTITSLIATKRRAAAEAAARTESIDA

Crispr_ID: NZ_CP018870_5

• CRISPR_ID: NZ_CP018870_5
• CRISPR_location: 1859937-1860072
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_5

Consensus_repeat	Method
CCACCACACCCCCGGCCGGGCCGCCCCACTTCAGCCCGCCG	CRISPRCasFinder

spacers of NZ_CP018870_5

>5.1|1859978|54|NZ_CP018870|CRISPRCasFinder
ACGCTTGAGGCGCGGGCCCGGACAACGCCCAGCTCCTGGCCCCACCCAGCCCCG

CRISPR arrays and Neighbor proteins around NZ_CP018870_5

CRISPR arrays

The CRISPR arrays of NZ_CP018870_5

>merge|NZ_CP018870|5|1859937-1860072|CRISPRCasFinder
CCACCACACCCCCGGCCGGGCCGCCCCACTTCAGCCCGCCGACGCTTGAGGCGCGGGCCCGGACAACGCCCAGCTCCTGGCCCCACCCAGCCCCGCCACCACACCCCCGGCCGGGCCGCCCCACTTCAGCCCCGCC

>NZ_CP018870|5|4|1859937-1860072|CRISPRCasFinder
CCACCACACCCCCGGCCGGGCCGCCCCACTTCAGCCCGCCG	ACGCTTGAGGCGCGGGCCCGGACAACGCCCAGCTCCTGGCCCCACCCAGCCCCG
CCACCACACCCCCGGCCGGGCCGCCCCACTTCAGCCCCGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_075970105.1|1863899_1864607_-|chaplin	unknown	unknown	gnl|CDD|367652
NZ_CP018870.1|WP_075972017.1|1866462_1869264_-|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|223627
NZ_CP018870.1|WP_075970099.1|1855264_1855828_+|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl|CDD|223427
NZ_CP018870.1|WP_030032231.1|1861180_1862635_+|WGR-domain-containing-protein	unknown	unknown	gnl|CDD|153425
NZ_CP018870.1|WP_075970102.1|1858877_1859789_+|sugar-kinase	unknown	unknown	gnl|CDD|238571
NZ_CP018870.1|WP_075970100.1|1857341_1857746_-|DUF861-domain-containing-protein	unknown	unknown	gnl|CDD|225981
NZ_CP018870.1|WP_045321603.1|1847972_1848956_-|TerC-family-protein	unknown	unknown	gnl|CDD|274743
NZ_CP018870.1|WP_052680576.1|1862598_1863075_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380364
NZ_CP018870.1|WP_075970101.1|1857936_1858881_+|pseudouridine-5'-phosphate-glycosidase	unknown	unknown	gnl|CDD|377251
NZ_CP018870.1|WP_079273424.1|1870937_1871642_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030032862.1|1864731_1865280_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_078848903.1|1856146_1857352_+|MFS-transporter	unknown	unknown	gnl|CDD|340883
NZ_CP018870.1|WP_030028961.1|1851874_1854052_-|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl|CDD|235395
NZ_CP018870.1|WP_030028960.1|1854308_1855229_+|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl|CDD|176543
NZ_CP018870.1|WP_075970103.1|1860439_1861087_-|uridine-kinase	unknown	unknown	gnl|CDD|180660
NZ_CP018870.1|WP_075970104.1|1863223_1863907_+|DUF2293-domain-containing-protein	unknown	unknown	gnl|CDD|370799
NZ_CP018870.1|WP_045321577.1|1849198_1851163_-|TerD-family-protein	unknown	unknown	gnl|CDD|132992
NZ_CP018870.1|WP_030028963.1|1851207_1851786_-|Tellurium-resistance-protein-terZ	unknown	unknown	gnl|CDD|376767
NZ_CP018870.1|WP_075972018.1|1869449_1870805_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|235906
NZ_CP018870.1|WP_045322434.1|1865260_1866466_-|zinc-finger-SWIM-domain-protein	unknown	unknown	gnl|CDD|226729

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_075970105.1|1863899_1864607_-|chaplin	gnl|CDD|367652	pfam03777, DUF320, Small secreted domain (DUF320). Small domain found in a family of secreted streptomyces proteins. It occurs singly or as a pair. Many of the domains have two cysteines that may form a disulphide bridge.	2.47797e-18
NZ_CP018870.1|WP_075972017.1|1866462_1869264_-|DEAD/DEAH-box-helicase	gnl|CDD|223627	COG0553, HepA, Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair].	8.1883e-119
NZ_CP018870.1|WP_075970099.1|1855264_1855828_+|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl|CDD|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	2.74778e-48
NZ_CP018870.1|WP_030032231.1|1861180_1862635_+|WGR-domain-containing-protein	gnl|CDD|153425	cd07996, WGR_MMR_like, WGR domain of molybdate metabolism regulator and related proteins. The WGR domain is found in the putative Escherichia coli molybdate metabolism regulator and related bacterial proteins, as well as in various other bacterial proteins of unknown function. It has been called WGR after the most conserved central motif of the domain. The domain appears to occur in single-domain proteins and in a variety of domain architectures, together with ATP-dependent DNA ligase domains, WD40 repeats, leucine-rich repeats, and other domains. It has been proposed to function as a nucleic acid binding domain.	2.76997e-18
NZ_CP018870.1|WP_075970102.1|1858877_1859789_+|sugar-kinase	gnl|CDD|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	3.40925e-53
NZ_CP018870.1|WP_075970100.1|1857341_1857746_-|DUF861-domain-containing-protein	gnl|CDD|225981	COG3450, COG3450, Predicted enzyme of the cupin superfamily [General function prediction only].	1.37988e-17
NZ_CP018870.1|WP_045321603.1|1847972_1848956_-|TerC-family-protein	gnl|CDD|274743	TIGR03718, R_switched_Alx, integral membrane protein, TerC family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains TerC itself from Alcaligenes sp. plasmid IncHI2 pMER610 and from Proteus mirabilis. It also contains the alkaline-inducible E. coli protein Alx, which unlike the two TerC examples is preceded by a yybP-ykoY leader.	5.04332e-138
NZ_CP018870.1|WP_052680576.1|1862598_1863075_-|cupin-domain-containing-protein	gnl|CDD|380364	cd02236, cupin_CV2614-like, Chromobacterium violaceum CV2614 and related proteins, cupin domain. This family includes mostly bacterial proteins homologous to CV2614, a Chromobacterium violaceum protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	4.89422e-14
NZ_CP018870.1|WP_075970101.1|1857936_1858881_+|pseudouridine-5'-phosphate-glycosidase	gnl|CDD|377251	pfam04227, Indigoidine_A, Indigoidine synthase A like protein. Indigoidine is a blue pigment synthesized by Erwinia chrysanthemi implicated in pathogenicity and protection from oxidative stress. IdgA is involved in indigoidine biosynthesis, but its specific function is unknown. The recommended name for this protein is now pseudouridine-5'-phosphate glycosidase.	1.16091e-151
NZ_CP018870.1|WP_078848903.1|1856146_1857352_+|MFS-transporter	gnl|CDD|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.40946e-23
NZ_CP018870.1|WP_030028961.1|1851874_1854052_-|excinuclease-ABC-subunit-UvrB	gnl|CDD|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NZ_CP018870.1|WP_030028960.1|1854308_1855229_+|glycerophosphodiester-phosphodiesterase	gnl|CDD|176543	cd08601, GDPD_SaGlpQ_like, Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized glycerophosphodiester phosphodiesterase (GP-GDE, EC 3.1.4.46) from Staphylococcus aureus, Bacillus subtilis and similar proteins. Members in this family show very high sequence similarity to Escherichia coli periplasmic phosphodiesterase GlpQ, which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	1.12202e-66
NZ_CP018870.1|WP_075970103.1|1860439_1861087_-|uridine-kinase	gnl|CDD|180660	PRK06696, PRK06696, uridine kinase; Validated.	1.54772e-19
NZ_CP018870.1|WP_075970104.1|1863223_1863907_+|DUF2293-domain-containing-protein	gnl|CDD|370799	pfam10056, DUF2293, Uncharacterized conserved protein (DUF2293). This domain, found in various hypothetical bacterial proteins, has no known function.	1.52252e-21
NZ_CP018870.1|WP_045321577.1|1849198_1851163_-|TerD-family-protein	gnl|CDD|132992	cd06974, TerD_like, Uncharacterized proteins involved in stress response, similar to tellurium resistance terD. Tellurium resistance terD like proteins. This family is composed of uncharacterized proteins involved in stress response, such as the tellurium resistance proteins, chemical-damaging agent resistance proteins, and general stress proteins from a variety of organisms. The tellurium resistance proteins are homologous terA,-D,-E,-F,-Z,-X gene products, which confer tellurium resistance mediated by plasmids. Currently, the biochemical mechanism of tellurium resistance remains unknown. The family also contains several ter gene homologues, YceC, YceD, YceE, for which there is no clear evidence for any involvement in the tellurium resistance. A putative cAMP-binding protin CABP1 shows a significant similarity to the terD protein and is also included in this family.	4.00375e-22
NZ_CP018870.1|WP_030028963.1|1851207_1851786_-|Tellurium-resistance-protein-terZ	gnl|CDD|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	9.30478e-54
NZ_CP018870.1|WP_075972018.1|1869449_1870805_-|helix-turn-helix-domain-containing-protein	gnl|CDD|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	8.19533e-11
NZ_CP018870.1|WP_045322434.1|1865260_1866466_-|zinc-finger-SWIM-domain-protein	gnl|CDD|226729	COG4279, COG4279, Uncharacterized conserved protein [Function unknown].	4.13463e-40

Protein sequences

>NZ_CP018870.1|WP_075970102.1|1858877_1859789_+|sugar-kinase
MTAPGALLVVGDVVTDVVAVHTEPLAPATDTAARIRTLPGGAGANAACWAARTGGAEVRLLARVGAESARWHERALVDAGVRPRLVVDPEEPTGTVVVLVGKDAERTFLTDSGASLRLCPADWDPSLLDGVAHLHLSGYLFFADGSRELATVALRAARTRGVPVSVDPASAGFLAALGPRRFLDAGAGAEVLLPNEDEARLLAGLPRGAGTGVAAAAAALSRRVPLVVVTRGPAGALVAERGRITAEVAATEPAGPVVDSTGAGDAFTGAFLASRLTGADPTESARAGCRAAAAAITHPGARP
>NZ_CP018870.1|WP_075970101.1|1857936_1858881_+|pseudouridine-5'-phosphate-glycosidase
MSQHRATAAPSGVPVLSEEVREALDRGRPVVALESTIIAHGLPRPRNLEVGLELEELVRAEGAVPATVAVVDGVSRAGLDKASLERIATGDGVRKLGHRDLAPALAAGATGATTVSATAFLAARAGLRVFATGGLGGVHREWAQTQDESADLSLLARTRITVVCAGVKSILDVPATLQRLETLGVGVLGYGTERFPGFYLADSGEPVDWTVHRPEEVAAVMAAQDALGGPESALLVANPVAAAEQLDPQLHDRVLAEALTECRKQGVTGQAVTPFLLGYLVRATGGASLEANLAAVRGNVRLGARIAGAWAARA
>NZ_CP018870.1|WP_075970100.1|1857341_1857746_-|DUF861-domain-containing-protein
MSTSDHSDAPAPAPAPASASAPASFAVDVADVELEPEDLDPAQIVSGDPVVTGKVLWESADGTQVRGIWQITPGVVTDVEANELFVVVSGRATVDVEGGATLEVGPGSACVLREGDKTVWTVHETLRKAYHISC
>NZ_CP018870.1|WP_078848903.1|1856146_1857352_+|MFS-transporter
MAGQILGGLGVPISIALAPVLATEVSGTEALSGFASTASVIGTALVSLPLAALMTARGRRPGLVLAYGIGAVGAGLVVLAATIRSFPLLLLGMAAFGAASSANLQARFAAADLAAPDHRARAISVVVWASTLGAVLGPNLSAPASRSFAGTSIPETAGPFVWAAVVFVLTGALIAVLLRPDPLLTARALAAPGEQGREARSIRAGIAAVRSSPRARLALLTVAVSHTTMVSIMVMTPVDLGHHGAGLELVGLVISGHIAGMFAFSPLMGWLADRLGRLSVIGLAAGLLSVAALLAGTAGPSHGRSALGLFLLGLGWSAGMVSGSALLTDSVPQAARAAVQGLSDLTMNTAAGVGGAAAGVIMSQAGYGWLNAVGASLLLPMGALALYTARRHPADSKGVSS
>NZ_CP018870.1|WP_075970099.1|1855264_1855828_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MDSTERPRGPHLEWTVVAGDIGPLLLAATPEGLVRVEFHAGPDRVDRMVGPLVSRLGADARRPEPGEEVLLAEPVRQIAAYFAGSLRRFDLPLDWRLSSGFNRQVLQELDRSVPYGSVVGYGELAARTGQPGAAQAVGNAMGSNPLPLVVPCHRVVENDGGIGGFGGGVETKRQLLALEGVLPQPLF
>NZ_CP018870.1|WP_030028960.1|1854308_1855229_+|glycerophosphodiester-phosphodiesterase
MYVRPAAAAAAAFLGLTLTLLGGTASSAATGPGSAPGPGSAAGPFGLGGPVVYAHRGASAYAPENTLAAVDLAMRLGFDWVENDVQRTKDGELVVIHDDTLARTTDVEQLFPDRKPWRVKDFTAAEIARLDAGGWFGEEYAGASVPTLRQYLDRVQRNRQRLLLEIKKPELYPGIEEQTLKVLGEAGWLDARHVSQRLVVQSFSADSVRIVHGLRPDVVTAFLGTPPVADLPRYAEFTDRINPWHTTISADWVAAVHGLLGAHGRAMEVDTWIVDDAATARKVQEMGVDGIITNAPDVVREAVGGF
>NZ_CP018870.1|WP_030028961.1|1851874_1854052_-|excinuclease-ABC-subunit-UvrB
MRPVSKIERTVAPFEVVSPYQPSGDQPAAIAELEKRIRAGEKDVVLLGATGTGKSATTAWMIEKLQRPTLVMAPNKTLAAQLANEFRELLPNNAVEYFVSYYDYYQPEAYVPQSDTYIEKDSSINEEVERLRHSATNSLLTRRDVVVVASVSCIYGLGTPQEYVDRMVALKVGEEIDRDQLLRRFVDIQYTRNDVAFTRGTFRVRGDTIEIFPVYEELAVRIEMFGDEIEALSTLHPLTGEVISEDRELYVFPASHYVAGPERMEKAIAGIEAELAERLDELEKQGKMLEAQRLRMRTTYDLEMMRQIGSCSGIENYSLHMDDRERGSAPNTLIDYFPEDFLLVIDESHVTVPQIGAMYEGDASRKRTLVDHGFRLPSALDNRPLKWEEFQERIGQTVYLSATPGKYELSRGDGFVEQIIRPTGLIDPEVVVKPTEGQIDDLVHEIRKRVEKDERVLVTTLTKKMAEDLTDYFLELGIQVRYLHSDVDTLRRIELLRELRAGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSGTSLIQTIGRAARNVSGQVHMYADKITPGMEKAIEETNRRREKQIAYNTANGIDPQPLRKKINDIVATIAREELDTEQLLGTGYRQAKEGKGAKAPVPALGGLAPHSPVGAKAAKNGGKGAKSAKGAQGAAVLTDRPAAELASLIEQMTDRMRAAAAELQFEVAARIRDEVGELKKELRQMKEAGLA
>NZ_CP018870.1|WP_030028963.1|1851207_1851786_-|Tellurium-resistance-protein-terZ
MTVNMTKGQAISLQKSDGGTLTAVRMGLGWQAAKRRGLFGSRTREIDLDASAVLFADKQPVDVVFFRHLQSDDGSVRHTGDNLVGGVGQGGDDEAILVDLQRVPVHIDQIVFTVNSFTGQTFQEVQNAFCRIVDETNGQELARYTLDGGGAYTAQIMAKVSRAGSGWQMTALGNPANGRTFQDLMPAILPHL
>NZ_CP018870.1|WP_045321577.1|1849198_1851163_-|TerD-family-protein
MTAELVRGQNHPVSESRVEIRVSAGTPVLALASLADEQGRLSGSGVLAHPGARALPGVRAPAELADRHTFPVDLDAVAADVHRVGVLLVLPPGGPVRFGAVPASHVAVAAPDGGGEIAGYTLTGLDAENAVIALELYRRQGAWKVRAVGQGYADGLGALLADGGLPAPAAGELAATVLRTAAPAKEADATLPARPTLVGDLRAPQPPAQAPAPAPEPPDPVPASGVPYAGTPGPAPAPGGDGSPPTISYTHPRRRRTSSEPPEPAPRPAAPPEPGQPPRPVAGDAGGWSMDERLYNQVWGMFEDLARTVAAYRSAVEFADNRMDRELDEALSDPRHRLGGTGNAARDTARARREELVGQAQAVLDRDLAQLIAEAEVVEPALPASYARWDNPVWHGHRTPEEGPLALRLGDLHLPERPDLRIPMLVRLPLERGLWIDNGRTGSEAAMAMDTDRLRRAAMDMAVAHAVRLLAVHPADRFSVHVIDAAGAGAPSLAPLVRAGVLAGPPAAGAAGVTRTLAELTRRVDLVQMALRAGAPEDLPPDVDTAEQLLIVHDFPHGFDDRAVTQLRYLADEGAAVGVHLLMVADRDEASAYGPLLDPLWRSLMRLSPVPDNHLADPWVQHAWTFEPSLPPQGSRVLDEALDRVAEARRTTRP
>NZ_CP018870.1|WP_045321603.1|1847972_1848956_-|TerC-family-protein
MEVSWALWAATVLGLSLLIAVDFLIGRKPHDVSIKEAGTWTVVWIVLAALFGLGLWFFGTPQASQEFFAGFITEKSLSVDNLFVFVLIMAKFAVPSHLQQRVLLVGVLIALVLRAVFIAAGAAIIASFSWVFYIFGAFLIYTAWKLIQEARKDEDEDEFEENRLLKSVEKKFGVADRYHGTKLFIVNNGKRVLTPLMIVMLAIGTTDVLFALDSIPAIFGLTQDPYIVFTANAFALMGLRQLYFLIGGLLEKLVHLSYGLSIILGFIGVKLVLHALHESGVHVPEISIPLSLGVICGVLVITTITSLIATKRRAAAEAAARTESIDA
>NZ_CP018870.1|WP_075970103.1|1860439_1861087_-|uridine-kinase
MQWEAITWQRMAERLAGHLDDPDHTPGPGAWQRVGIDGAPAADTGALAGRLADELRLRGRSVLVVPTAGFLRPASLRFEFGRQDVDAYLDGWYDTAALWREVFGPTDPGGTGRVLPDLWDPVTDRATRSPYAELPAGGVLLVHGPLLLGRWFPFDLTVHVRLSAGALARRTEESERWTGAAFARYEAEVDPGAAADVVVRADDPRHPAWTGIRGR
>NZ_CP018870.1|WP_030032231.1|1861180_1862635_+|WGR-domain-containing-protein
MARETTYLELSQDGGGAHKFYEVTVDGTAVSVRYGRIGAPGQLQSSSFPTAEKARAAAAKKIGEKVRKGYAPAVQGQRAARAVTRRQVASAPSTARAVAPVLWRFRTGSAAFGIHVDEDRCWVGNQAGDVYTLSHGGEVLARYSLPDGVKCLVADEFWIYAGCDDGTVYDLSSKVPFGAYAIAADVDIYWLDIHEGVLNVSDANGGLTVIDHEDEHQWSRKSAGRGAWMVRADERAVYHGHSGGVTAYAADGTGQLWHSATPGGVLFGWQEEHSVYAGTVRNTVQRLSKASGATEAVYRCDAAVYSCATSPDGRHVFAGDSSSSVYCFDAEGNRLWKLGTGGGSALSMQYLDGRLYLVTTDGSLVCVDASEQAIAAAQQGSVPAPMDVKSAAALPVFTPAASAAAVATVSMAAVASEPAGGVVVECVQQGGRVRVQVVSSGFEPSWNVQFPRGIREAGARYVVDGLHAASGGFYRVRGEIRRLV
>NZ_CP018870.1|WP_052680576.1|1862598_1863075_-|cupin-domain-containing-protein
MGTRRTTTARPQVTGFGFDIGTGRSCVTTIPAGREIVIPPGGCTGWHFHRVRLEAVVLSGTLTRVLHDLTEEVHRPGTTFLEPAGIGHIHLGHNLGTEPVVLHVTPRLPEGTPFSIPVPAPAGATRDVCRRHPPQPPQPPAEPGGPPHTSRRISPRTR
>NZ_CP018870.1|WP_075970104.1|1863223_1863907_+|DUF2293-domain-containing-protein
MSLVVFESVKQIHCAECRSGPLRHLVREAGVPRCLDCADLGHLVYLPRGDTALTRRAREASSLSAVVVRFHRRRRRYERLGLLVEDAALAGAERACLADSEARARRRERDRLRRAAEDVRFTAAFAAEIVRLFPGCPADRAVAIATHASVRGSGRVGRTAAGRSLDETAVSVAVRAAVRHTDTEYDALLMAGVPRFTARARLAPRIDAILDGWRSVPRDRAQRGWAS
>NZ_CP018870.1|WP_075970105.1|1863899_1864607_-|chaplin
MRHSRRNGLIAAVVAGGGLAVAGVSGLAHADADAGGTAERSPGLLSGNLVQLPVNVPVSACGNTVNVVGLLNPAAGNRCTNTSQGGGAHSGQSGSDRSTPAAGNGGGAVASGQTANSPGVLSGNGLQLPVDLPVNVSGNSVNVVGIGNPSHGNTSVNAEQPGPGKPVQPPVVEQPVTPAVPTSPNSPVTEVTPPEPPRHSEALAQTGADGVGYMLPAGGALLLGGAMLYRRFRLN
>NZ_CP018870.1|WP_030032862.1|1864731_1865280_+|hypothetical-protein
MTERPLLLLDVDGPLNPFRSPFAGLRGYKSHRMWPEVWLSYRDPESRRARRGARIRLHPSHGSRLLSLPFELAWATAWTHQANTLISPHIGLPGDLSVVEWPELFAKDPDGLSWKTRHLRDWAAGRPFAWVDDMITPLDRAWVAAHHPAPALLLRIHPRHGLRDRDFTALTRWAEGLSPAGR
>NZ_CP018870.1|WP_045322434.1|1865260_1866466_-|zinc-finger-SWIM-domain-protein
MITARDDRRRTFETVPAGAAAVSWWGRAWVAALEETSGDPARLARGRTYAESGHVDAVTVTPGRIVAYVRGSRPRPYRTELTLPAFADARWSELLEDVAADPAALGALLEREVPQSLAGTVLPGAGELVPHCSCPDVGRPPCKHAAALCYRAARLLDEDPFVLLLVRGRGERELLEDLTRRNAAHAAREQPGTAPDFPGVPARAALARRAVPPLPVPLAAPAAAGLPPAYPADPAAPDPLALDQLASDAAARALTLLTTGEDPIAGLSLWHDAVRLASAHPTAGLTGTARTLYRDLARATGRTTTDLARAAAAWRQGGRPALAALEEPWDPPAGPFDRARPALLAASQGSFRPDRNRLTARTRQLRLGRDALWYAYESRPDHEDWWPTGRPSPDPVTALLG
>NZ_CP018870.1|WP_075972017.1|1866462_1869264_-|DEAD/DEAH-box-helicase
MLRHAAVFLPAAVPREGRIAFWSPDGDPLPEAGASGPLTVVRPHGSGIRSRTVPSVAFSVADALPLLLRAPRSPSAHPATRAWGTAATQALTLAARGRLLPGLTAEGVDAWRAGPLDADDIAHLRAVAAALPHEGHATPLAGRRPLQLPEPEALVRAFVDAVADSLPRTPAAPVAAGRPFAAREAQRVPGIQEWAAQVAAGADTGVGLSLRLDLSSFRLFDEAEPEDTRRAGAAVVQVHSLADPTLVTDAAQLWAGTAGAGFGPRARIDAVLALRRAARVWPPLLRLLDQPVPDALALSDPELEDLLGTAANRLAAAGVVVHWPRDLARTLSATAVVRSTAPGSATDGTAFFDAEHLFAFSWELALGGDRLTPGEMDALAQAHRPVVRLRDQWVRVDPELVRKARKRELGLLDPVDALAAALSGTAEVDGEPVEAVPVGALAALRERLTAELTPLPQPAGLKAVLRDYQARGLAWLDLMTSLGLGGCLADDMGLGKTVTLIALHLHRGRREPTLVVCPASLLGNWQREIEKFAPGTPVRRFHGGGRSTEDLTSCEGGFVLTTYATMRASAALLAEQPWGMVVADEAQHVKNPHSATAKALRTIPAPARVALTGTPVENNLSELWALLDWTTPGLLGPLTTFRARHARPVEHQQEEDGGNEAAVARLAALVRPFLLRRKKSDPGIAPELPPKTETDHPVSLTREQASLYQAAVDEAMAVIGESEGIERRGMIMKLLASLKQICNHPAQYLKEEHPRLPHRSGKLALLDELLDTIVAEGGSVLVFTQYVTMARLIERHLSARGIATQLLHGGTPVPRREELVDRFQAGEVPVFLLSLKAAGTGLNLTRAGHVVHFDRWWNPAVEEQATDRAYRIGQTQPVQVHRIIAEGTVEDRIAEMLEAKRALADAVLGSGEAALTELTDRELADLVSLRRPA
>NZ_CP018870.1|WP_075972018.1|1869449_1870805_-|helix-turn-helix-domain-containing-protein
MRELKERGGLSYGVLARRLHTSTSTLHRYCNGEALPVEFAVLDRFARACGASAAEAVDLHRAWLLADARRRAGTAAAEPSRAWGEPGAAVPEPVPAGAGGESDPAGAGGESDPAGAGGESDPAVPAVVVGSVGRAAAGAGARSSWYRRRAVVVAAAGLAAGAAAVALLAVTGPDRGAPHTGPAPGPGAGAGTRGAGGSAAAATPPAPGSPPADPATGPAQPAAPAGGGATEPAPDSAPPPVPAPGRAPAVPLKASVRPHVWAAGCDHAYLSERGPGSVAPPPVQADAAAWATAQRAVHAGSQIVEVTLHGAGGGTVVLEGLEVRVVARRTPPAWNVYQMSQGCGGGLTPAVFAVNLDAPRPLARPVAGNDAGNRLPAPAFPMRVSADEPVVLRVEAATTGCDCDWSLDLRWTSPAGSGTLRVDDGGRPLRTSASTGRPVYGYALEQGRWAR
>NZ_CP018870.1|WP_079273424.1|1870937_1871642_+|hypothetical-protein
MSPRTVAPRPRRGTGFSRTTDAASTGRTDMFRRTDTAATVATALVAAAATLALTAPASAAPAGAPGFLNGTDLPAHPSSPWYAGEITKGLPETETFCLDGVLPTAGSWHRAFGTEYDTGAVQISVRSASPAAAAKLAGALERKVAACAADWLRTTPGGTASWQDYGTLPVEEGAHVYGVHTSIPESEPGVHLYGIGRDGSTVTVVKWGQMGDLSQAPVAPFRKTTTKAVDKLNP

Crispr_ID: NZ_CP018870_6

• CRISPR_ID: NZ_CP018870_6
• CRISPR_location: 1908695-1908849
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_6

Consensus_repeat	Method
CCCCGTAGGCGCCCGCCCGCAGGGCACCCCGCAGGG	CRISPRCasFinder

spacers of NZ_CP018870_6

>6.1|1908731|83|NZ_CP018870|CRISPRCasFinder
CCCCGCCCGCACGGCACCGGCCGCCGGGTACCCGACAGCACCCGCCCCGCAGGCACCGCACCGCCGGGTGCCGCACGGACTCG

CRISPR arrays and Neighbor proteins around NZ_CP018870_6

CRISPR arrays

The CRISPR arrays of NZ_CP018870_6

>merge|NZ_CP018870|6|1908695-1908849|CRISPRCasFinder
CCCCGCAGGGGCCCGCCCGCCGGGTACCCGTAGACGCCCCGCCCGCACGGCACCGGCCGCCGGGTACCCGACAGCACCCGCCCCGCAGGCACCGCACCGCCGGGTGCCGCACGGACTCGCCCCGGAGGGGCCGGACCGCCGGGTACCGGACAGCA

>NZ_CP018870|6|5|1908695-1908849|CRISPRCasFinder
CCCCGCAGGGGCCCGCCCGCCGGGTACCCGTAGACG	CCCCGCCCGCACGGCACCGGCCGCCGGGTACCCGACAGCACCCGCCCCGCAGGCACCGCACCGCCGGGTGCCGCACGGACTCG
CCCCGGAGGGGCCGGACCGCCGGGTACCGGACAGCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_045324056.1|1914409_1915114_+|hydrolase	unknown	unknown	gnl|CDD|319765
NZ_CP018870.1|WP_075970114.1|1911574_1911928_-|chorismate-mutase	unknown	unknown	gnl|CDD|181719
NZ_CP018870.1|WP_075970115.1|1913345_1914242_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030028967.1|1915327_1916239_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|236099
NZ_CP018870.1|WP_030026526.1|1900209_1900914_-|SIMPL-domain-containing-protein	unknown	unknown	gnl|CDD|377344
NZ_CP018870.1|WP_045324062.1|1905870_1907229_-|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl|CDD|99743
NZ_CP018870.1|WP_045322448.1|1897870_1898467_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|224584
NZ_CP018870.1|WP_075970117.1|1917061_1917811_+|enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl|CDD|181174
NZ_CP018870.1|WP_030026532.1|1896162_1896819_-|response-regulator	unknown	unknown	gnl|CDD|226230
NZ_CP018870.1|WP_075970118.1|1917807_1918659_+|CoA-transferase-subunit-A	unknown	unknown	gnl|CDD|224702
NZ_CP018870.1|WP_037665058.1|1912421_1913195_-|serine-protease	unknown	unknown	gnl|CDD|238113
NZ_CP018870.1|WP_075970113.1|1904464_1905874_-|SidA/IucD/PvdA-family-monooxygenase	unknown	unknown	gnl|CDD|226017
NZ_CP018870.1|WP_075970119.1|1918655_1919423_+|CoA-transferase	unknown	unknown	gnl|CDD|224968
NZ_CP018870.1|WP_030026534.1|1895375_1896092_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|223487
NZ_CP018870.1|WP_037663554.1|1909026_1911531_-|aminopeptidase-N	unknown	unknown	gnl|CDD|274121
NZ_CP018870.1|WP_030026531.1|1897084_1897861_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_045322450.1|1901041_1902856_+|nucleotidase	unknown	unknown	gnl|CDD|236506
NZ_CP018870.1|WP_075970112.1|1902941_1904417_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_045322449.1|1898636_1900064_-|pyruvate-kinase	unknown	unknown	gnl|CDD|180487
NZ_CP018870.1|WP_075970116.1|1916240_1917005_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|236116

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_045324056.1|1914409_1915114_+|hydrolase	gnl|CDD|319765	cd01624, HAD_VSP_like, vegetative storage proteins and related proteins, similar to soybean VSPalpha and VSPbeta proteins; belongs to the haloacid dehalogenase-like superfamily. Soybean [Glycine max (L.) Merr.] vegetative storage protein VSPalpha and VSPbeta levels were identified as storage proteins due to their abundance and pattern of expression in plant tissues, they accumulate to almost one-half the amount of soluble leaf protein when soybean plants are continually depodded. They possess acid phosphatase activity which appears to be low compared to several other plant acid phosphatases; it increases in the leaves of depodded soybean plants, but to no more than 0.1% of the total acid phosphatase activity in these leaves. This acid phosphatase activity has maximal activity at pH 5.0 - 5.5, and can liberate Pi from different substrates such as napthyl acid phosphate, carboxyphenyl phosphate, sugar-phosphates, glyceraldehyde 3-phosphate, dihydroxyacetone phosphate, phosphoenolpyruvate, ATP, ADP, PPi, and short chain polyphosphates; they cleave phosphoenolpyruvate, ATP, ADP, PPI, and polyphosphates most efficiently. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Soybean VSPalpha and VSPbeta lack this active site aspartate, other members of this family have this aspartate and may be more active. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.47358e-39
NZ_CP018870.1|WP_075970117.1|1917061_1917811_+|enoyl-CoA-hydratase-family-protein	gnl|CDD|181174	PRK07938, PRK07938, enoyl-CoA hydratase family protein.	1.22502e-157
NZ_CP018870.1|WP_030028967.1|1915327_1916239_-|SDR-family-oxidoreductase	gnl|CDD|236099	PRK07791, PRK07791, short chain dehydrogenase; Provisional.	2.40494e-155
NZ_CP018870.1|WP_030026526.1|1900209_1900914_-|SIMPL-domain-containing-protein	gnl|CDD|377344	pfam04402, SIMPL, Protein of unknown function (DUF541). Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.	1.87723e-35
NZ_CP018870.1|WP_045324062.1|1905870_1907229_-|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl|CDD|99743	cd06450, DOPA_deC_like, DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.	1.05612e-73
NZ_CP018870.1|WP_045322448.1|1897870_1898467_-|GNAT-family-N-acetyltransferase	gnl|CDD|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	2.83205e-24
NZ_CP018870.1|WP_030026532.1|1896162_1896819_-|response-regulator	gnl|CDD|226230	COG3707, AmiR, Response regulator with putative antiterminator output domain [Signal transduction mechanisms].	1.23977e-63
NZ_CP018870.1|WP_075970118.1|1917807_1918659_+|CoA-transferase-subunit-A	gnl|CDD|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	1.6275e-62
NZ_CP018870.1|WP_075970113.1|1904464_1905874_-|SidA/IucD/PvdA-family-monooxygenase	gnl|CDD|226017	COG3486, IucD, Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	1.62563e-158
NZ_CP018870.1|WP_075970119.1|1918655_1919423_+|CoA-transferase	gnl|CDD|224968	COG2057, AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism].	2.06312e-30
NZ_CP018870.1|WP_030026534.1|1895375_1896092_+|ABC-transporter-ATP-binding-protein	gnl|CDD|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	3.85404e-130
NZ_CP018870.1|WP_037663554.1|1909026_1911531_-|aminopeptidase-N	gnl|CDD|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0
NZ_CP018870.1|WP_037665058.1|1912421_1913195_-|serine-protease	gnl|CDD|238113	cd00190, Tryp_SPc, Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.	2.3749e-71
NZ_CP018870.1|WP_045322450.1|1901041_1902856_+|nucleotidase	gnl|CDD|236506	PRK09420, cpdB, bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.	1.06223e-129
NZ_CP018870.1|WP_045322449.1|1898636_1900064_-|pyruvate-kinase	gnl|CDD|180487	PRK06247, PRK06247, pyruvate kinase; Provisional.	0
NZ_CP018870.1|WP_075970114.1|1911574_1911928_-|chorismate-mutase	gnl|CDD|181719	PRK09239, PRK09239, chorismate mutase; Provisional.	5.17939e-54
NZ_CP018870.1|WP_075970116.1|1916240_1917005_-|SDR-family-oxidoreductase	gnl|CDD|236116	PRK07856, PRK07856, SDR family oxidoreductase.	7.42593e-125

Protein sequences

>NZ_CP018870.1|WP_045324062.1|1905870_1907229_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MAGGAHGARALRPLLDTVLDALHTGTAERPGPLPAGGPATVTARIRAALGTVLPDHGTGDHEALHTLVRALAAGAADPAHPHCAAHLHCPPLAVAAAADLAAAALNPSLDSWDQAPAASTLEAELTRTLAAEFYATPHPDALITTGGTEANQLALLLARERHGPHLTVLHGANAHHSIPRAAWLLGLPPTVVLPTPTGVLDPARLAEALATTPGPTLVTATAGTTDAGLIDPLPAIADLCDHHRADLHIDAAYGGLLALSPHHRHKLTGLDRAHSLTVDLHKLGWQPVAAGLLTVPDTTLLTPLAHHADYLNPTDDTEAGLPDLLGRSLRTTRRPDALKIAATLRSLGRNGLTHLIDRTCALAHHLAQRLDAHPRFELHSTPTLTTVLFRPTHATDDEVATQRRALLHQGLAVLGRTHADGRLWFKATLLNPHTTAGDLDTLIAHLEGSTHR
>NZ_CP018870.1|WP_075970113.1|1904464_1905874_-|SidA/IucD/PvdA-family-monooxygenase
MTAQLDAPHDLVGIGIGPSNLSLAALAHGLPHQGAGELATVFYEQRRDFRWHPGLLIEGATLQVPFLADLVTLADPASPWSFLSYLKHKERLYPFYFAEQFHIHRAEYDAYCRWVAGRIPGLHFGHQVDAIRWNPERDLFEVDFTQLDPTGEAQALGRTYTRNLALGIGTAPHIPEPLRPLAEAPTVPVIHSADYLDHRPRILGAEHVTVIGSGQSGAEVFLDLLRARPAGRERLTWLARTPSFAPMEYSKLGLEHFTPDYTRYFHSLPEPVRDHLVPAQWQLHKGIDTATIAAIHDELYRRTLHGGWPDAVLTPGVTVRTAGRIATTKIELHLEHGEQGARSRLTTDAVVLATGYKERPLTRLLAGLDPYLRKDSSGRPRIDDRYRMILDPSVTGSIFVQNGERHTHGVGAPDLGLAAWRSAAILNTLTGKEAYPQPPRTAFTTFGLEQREHTRPRPAGELRPLVEHP
>NZ_CP018870.1|WP_075970112.1|1902941_1904417_-|hypothetical-protein
MQRTSADGVTVLWEAAPGPGPLSAVLSFGTGTRDETAPTLGATRLVETLVMTPVGKRPHEFTSIVEEEATHFIAKGTPAEVTGFLHAVCNALLDLPTHHIEHATRLLTIEDPRTRDHRGAEPLSARYGPHALGLTTHHHPDTYSRHTPDTVRSHAATHFTRGNAVLALDGPPPPGLTLPLPVGPRPHRTTPHTRPGVPGTWQHRQIDTVSLLLTSHIHEPAAVTACHTLSRRVEHLAHDTLAFTDRATTHTFLRDRLTLDRVLTLRPADGHGEQAAEILWHEALDLARQGPTRHELDSFTAHTRTAPDSESRLWHSLHRAVEAEHFGIPYHDTPSLLAGHATTTAQDVAHYMQRALTDAVLVVPHQVFPRLKTPHGKRLPNSDCWRPHGQHPPTPGTRFRMNPFRRVTTPRHEHGEYVLTDWGLVIRDAERDEHDIRFADIALMLHDGPGRIVLTGCGCHTHLHPQQVARGDRLIAALDAAVPAHLVHTDT
>NZ_CP018870.1|WP_045322450.1|1901041_1902856_+|nucleotidase
MAFDRRTFIGTTAATGAAVALVGATGTPAAAAQQDAGRKPGRPGPRTYAFTVMGTTDLHGNVFNWDYFTDAEFDDKAHNDVGLAKISTLVDQVRAEKGRCNTLLIDAGDTIQGTQLSYYYAKVDPITARRGPVHPMAQAMNAIGYDAAALGNHEFNYGIPVLRKFEEQCDFPLLGANALDAKTLRPAFAPYSMHRLRTPHGRDVKVAVLGLTNPGIALWDKANVQGKMTFPGLEEQAAKYVPRLRSMGADVVIVSAHSGSSGTSSYGDQLPYVENAAALVAEQVPGIDAILVGHAHTEIPEYRVRNKATGKDVVLSEPLKWGQRLTLFDFELVWEKGRWSVAKVAAKVLNSNTVAEDAKITRLLSDEHRKVVAYVNQVIGTSTQAMSSAEGPVKDVAIIDLINHVQAETVKGALAGTEWAALPVLSQASCFSRTAAIPAGQVTIRDAAGLYPFENTMEARLLTGAQLKDYLEFSARYFVRTAPGDVVDAAKLTNAEAIPDYNYDAVYGLSYDIDIAQPSGSRISGLSFEGKPVDPAAQFVLAVNNYRASGGGNFPHVPQAKQLWSNSDEIRNTIISWVKAKGTIDPAQFASVDWRLTRAGVPVF
>NZ_CP018870.1|WP_030026526.1|1900209_1900914_-|SIMPL-domain-containing-protein
MTQDAPHQPYGTPDVPRVAVHGEARLEVDPEIARIGITVNARGTDRRTALEDLTRRNNTVLDLLKNHGDTVEKLETGALSITPELTRHGRSERIRAYHGRVHITAELSDFTTLGELTTRLADLELTQVDGPWWALRPTSPAHGQARRQAVLDAVQRAREYAEALGARLTALTELADLGAENTTPYPQAPGGSGMRTMAFSTTEDAGPPPLDLEPQRQTVYAQVNARFTMTPPQL
>NZ_CP018870.1|WP_045322449.1|1898636_1900064_-|pyruvate-kinase
MRRAKIVCTLGPATDSYDQIKALVEAGMDIARLNLSHGTYAEHEERYQRVRKASDETGHSVGILADLQGPKIRLGRFREGPVLLERGDHFTITVEDHPGDRHTCSTTYTGLATDVTTGERILVDDGRVTLEVTHIDGPRVHTRVIEGGMVSDHKGLNLPGVAVSVPALSDKDIEDLRWALRTGADVIALSFVRSGHDIQDVHRIMDEEGRRLPVIAKIEKPQAVDNIDDIVAAFDGIMVARGDLGVEMPLEQVPIVQKRAIKLAKRNAKPVIVATQMLDSMIDNSRPTRAEASDVANAVIDGTDAVMLSGETSVGKHPVETVRTMSRIVEAAEEDILAKGLPPLTDRNKPRTQGGAVARAAAEMGDFLDAKFLVAFTQSGDTVRRLSRYRSPIPLLAFTPDPATRSQLNLTWGVETFLGPHVDSTDAMVAQVEEELLRIGRCVPGDTVVITAGSPPGVTGSTNLVRIHHIGDPVR
>NZ_CP018870.1|WP_045322448.1|1897870_1898467_-|GNAT-family-N-acetyltransferase
MSTPIPDRRTFVRTTLDLGEATLHPWGRKPAGPELLDDLVTAAADPTIALWNPLPAADHQAAQTWLEAREDGWDRGVGAAFAVLSATDSALLGTVNLRWTDRADGLAMIGYWFLPAARGRGLATRATRAVTTWGFSTADARRIELAHAVGNQASCRVADRCGYHPEGILRESHLFGDGRHHDEHLHARLATDPEPNRP
>NZ_CP018870.1|WP_030026531.1|1897084_1897861_+|hypothetical-protein
MRLHSLEVRQTALSLLRSGTKNAEVSRRLNVPVGTISHWKHIDRAKRGECPGAHVPECPRCDGSPLDSEAYAYALGLYLGDGHISHYSGHRVPTLQITCDDKWPGLMDHAEEAIRRLFPYNRVCRAKKVGCHDVKVYSKHLECLFPQHGPGKKHERRIILEDWQQEIVDAHPWEFVRGLIHSDGCRVTNWTVRNGKRYEYPRYFFTNKSDDIRKLCTDTLTKVGVRWTVLARGSDPFNVSIARKDSVALMDAHIGPKY
>NZ_CP018870.1|WP_030026532.1|1896162_1896819_-|response-regulator
MTAEHESTPTPDADQSHVPPLTTRVVIAEDEALIRLDLKEMLEEEGYTVVGEAGDGQTAVELAREHRPDLVILDVKMPVLDGISAAEKIAQESIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRFAELRALEQEVADLSQRLETRKLVDRAKSILQTQYGLTEPAAFRWIQKSSMDRRMSMQQVAEVVIEDAESKKKESGGR
>NZ_CP018870.1|WP_030026534.1|1895375_1896092_+|ABC-transporter-ATP-binding-protein
MTALLKVEDLKVAYGKIEAVKGISFEVNEGEIVCLVGTNGAGKTTTLRTLSGLLKPTSGSVVFDGQPIVGVPAHKIVSLKLAHSPEGRHIFPRLTIEENLQLGAFLRSDKDGIEKDIQRAYDLFPILGERRKQAAGTLSGGEQQMLAMGRALMCQPKLLMLDEPSMGLSPLMMQKIMSTIAELKASGMTILLVEQNAQAALSLADQAHVMEIGKIVLSGTGQDLLHNEDVRKAYLGED
>NZ_CP018870.1|WP_037663554.1|1909026_1911531_-|aminopeptidase-N
MSALTRNEAQLRAQLLDVHDYAVRLDLTTGDDTFDSATTIRFTARTTGDTFVELKPEELRSATLDGHPLDPAALDDNRLPLTLTPGDHELRIDARMRYSHTGEGLHRFTDPADGETYVYSQMFLDDVQRVLPAFDQPDLKAVFQFTVTAPAHWTVLANGITTRLADRDSDGAGIWQSAPTPLISTYLAAVAAGPWHSVTTQHAGLPFGIHCRQSLAPHLDADADEILSITTACFDRYQTKFTEPYPFDSYDQAFVPEFNAGAMENPGLVTFRDEFIYRSAVTDTERQSRAMVIAHEMAHMWFGDLVTLAWFDDIWLNESFAEYMGYQTLTEATRFTDTWTAFGVTRKPWGYEADQRPSTHPVAPEDVPDTASALLNFDGISYAKGASALRQLVAWLGEEDFLAGINTHFARHKFANASLADFIDSLAAHTRRDVRAWADAWLRTTGIDTLTPRIEDAPHGTAGWTLTIDRDGSRPHHIAVGVYDRDPADGHTLELRELLDLDVPSDEVVSTSGTRPALLLLNDADLTYAKIRLDETSLETVLRGLSGIPEALTRAVVWNCLRDMVRDGELDPRDYLTTAEAHLPAEHDLAIVQGVLAFARTEIAVRHLAPEDRTAALTTLTTIARDLLRRTEDGTEPGMRLTAVRTLIGSATQPDTIAAWLADDTVPGGPALDPELRWRILGRLAVLGAVDETDIDAALTADPSATGEEGAARCRAALPTPEAKAAAWNRLFHDDTLSNYLFTAIAQGFWQPEQSDLTAEYVTRYYPEAVALGARRGPAIGEAAGRYAFPAYAVDEANLKAGQACLADPDIIPLLRRKLADQLDDLSRALHIRG
>NZ_CP018870.1|WP_075970114.1|1911574_1911928_-|chorismate-mutase
MNHSDHDNGPGSDTAAADGIDENVTAELARLRDSIDNIDAAVVHMLAERFKCTQQVGHLKARHQLPPADPGREASQIARLRQLAENAKLDPAFAEKLLNFIIAEVIRHHETIAAGED
>NZ_CP018870.1|WP_037665058.1|1912421_1913195_-|serine-protease
MTSLVRFMKRTLAVGAVALAAVSLQPGTASAGTAPVVGGTRAAQGEFPFMVRLSMGCGGALYTQQIVLTAAHCVNGSGNNTSITATAGVVDLNSSSAIKVKSTKVLRAPGYNGTGKDWALIKLAKPVNLPTLKIAETKAYDNGTFTVAGWGATREGGSQQRYLMKATVPFVSDADCGAAYSDLVPGEEICAGRLGQGGVDTCQGDSGGPMFRRDNAGAWIQVGIVSWGIGCARPDYPGVYTEVSTFAAQIKSAAATL
>NZ_CP018870.1|WP_075970115.1|1913345_1914242_+|hypothetical-protein
MKENRGRSGAVEHGFPHLATVRAAITALFRRLSADGVRAYATSLSPADAAFDASDDLHLGAQRVASAVVRALRLPDARMVVAFRPMEEAATVELAAGPEYFVEVNDRFRTHRRDLAAALSHEAAHVLLHRLELVFPDPAENEILTDTAAAYLGAGWLLLDAYREDALTRQRFGYLTPEEFGYVLAKRAVLFGEDPSTWFTSPQAYEAYVRGSALAARDLRRAPLAAAGPGARRRYARARRGGGVPADGSAYRFEREGSGPGLRVSFPCPVCEQRVRVPVGGRLRARCGLCRSVLDCDT
>NZ_CP018870.1|WP_045324056.1|1914409_1915114_+|hydrolase
MRSSRRIRTPRTAAVGVAAAAALLTLVPATAAQAAPAAAPAPVSAPATAATAATTATASAPGGNAAILGIDYAAWQREVAAIVDAARPAIEQRIANSPAGEKPALVLDIDNTSLETDFHWFWTYPTPAISKVRALTQYAHARGVAVFFVTARPGIIHSLTDYNLKAVGYPVSGLYVRDLPDLFEEVSAYKTAKRAEIEARGYTIIANIGNSPTDLVGGHAERTVKLPDYNGKLS
>NZ_CP018870.1|WP_030028967.1|1915327_1916239_-|SDR-family-oxidoreductase
MAGLCEGRVVIVTGAGRGLGRAHALAFAAEGAKVVVNDLGVELDGLPGPQSPAAQVVREIEALGGEAVAHGGDVATARGADSLVEAAVDAFGRLDTLVNNAGFLRDRMLVNLDEDDWDAVVRVHLKGHFLPLRSAAAWWRAEAKAGRPVAARVVNTSSGAGLLGSVGQGNYSAAKAGILGLTLVAAAETGRYGVQVNAIAPAARTRMTEQAFAQTMAAPEDGGFDAMAPENVSPLVVWLGADASAGVTGRVFETEGGRITVMEGWRPGPTADRGARWTPAEAGEAALKLLAAAEPPLPAYGSR
>NZ_CP018870.1|WP_075970116.1|1916240_1917005_-|SDR-family-oxidoreductase
MELDGRVVVVTGGTRGVGAGIARSFLQAGAEVVVCARRPPDGPVSADGREASFTALDLRDTGAVRDFFDAVGDRYGRLDCLVNNAGGTPYRLLGEGGAERHARVVELNLLAPLTASLAAHPWLRRTGGSVVMIGSVSGTRPSPGTAAYGAAKAGLESLARSMAVEWAPEVRVNSLVLGMVRTELAHLHYGDEAGIEAVGATVPLGRLAEPDEVGDAAVFLASDRARYVSGAALLVHGGGERPAFLDAATVNKGS
>NZ_CP018870.1|WP_075970117.1|1917061_1917811_+|enoyl-CoA-hydratase-family-protein
MGVSTSRPDKGVALVTVDFPPVNALPVQGWYDLADALRSAGRDPEVRCVVLAADGRGFNAGVDIKEMQRDTGHTALIGANRGCYEAFAAVYECEVPVVAAVNGFCLGGGIGLAGNADAIVASDDAVFGLPELDRGALGAATHLARLVPQHLMRALYYTSRTATAAELHAHGSVWRVVPREVLRGAALELAAEIAKKDGCLIRLAKAAINGIDPVDVRRSYRFEQGFTFEANLSGVADRVRDTFGKGERA
>NZ_CP018870.1|WP_075970118.1|1917807_1918659_+|CoA-transferase-subunit-A
MSDKTMTAEEAVGQLRSGMTLGIGGWGSRRKPMALVRALLRSEITDLTVISYGGPDVGMLAAAGRIRRLVAPFATLDSIALEPHFRAARERAAFTLTEYDEAMFMWGLHAAANRLPFLPVRAGLGSDVMRVNPELRTVTSPYGDGEELVAVPALRMDAALVHLNRADRLGNAQYLGPDPYFDDLFCEAADAAYVSCEQLVETAELAKAGPPQSLLVSRHSVTGVVEAPNGAHFTSCAPDHGRDEAFQKLYARTPWPEFSARFLTGAGEQDYQSAVRTWHEEQQ
>NZ_CP018870.1|WP_075970119.1|1918655_1919423_+|CoA-transferase
MTTTPAGTDRSTGTGGATRAEYCVIACAEAWRGDGEVLASPMGLIPSIGARLAKRTFSPDLLLTDGEAMLVGLDGTPEGWLPYRRHLAMVTGGRRHVMMGASQIDRFGNQNISCIGDWERPARQLLGVRGAPVNTLNNPVSYWIPKHSARVFVERVDMVCGVGHDRAAEAGVARFHRLPRVVSDLGVFDFAGPGHSMRLASLHPGVTVEQVRAATGFELALPEEVPYTREPTEEELRLIREVIDPQGLRDREVRG

Crispr_ID: NZ_CP018870_7

• CRISPR_ID: NZ_CP018870_7
• CRISPR_location: 2056193-2056302
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_7

Consensus_repeat	Method
CGGGCACTTCTCAGCCCCGCCGGCGTTCGAGGCGCGGGG	CRISPRCasFinder

spacers of NZ_CP018870_7

>7.1|2056232|32|NZ_CP018870|CRISPRCasFinder
CCTGAGGCGGAGCCCCCGCTCTTCCGCCCCGC

CRISPR arrays and Neighbor proteins around NZ_CP018870_7

CRISPR arrays

The CRISPR arrays of NZ_CP018870_7

>merge|NZ_CP018870|7|2056193-2056302|CRISPRCasFinder
CGGGCACTTCTCAGCCCCGCCGGCGTTCGAGGCGCGGGGCCTGAGGCGGAGCCCCCGCTCTTCCGCCCCGCCGGGCACTTCTCAGCCCCGCCGGCGTTTGAGGCGCGGGG

>NZ_CP018870|7|6|2056193-2056302|CRISPRCasFinder
CGGGCACTTCTCAGCCCCGCCGGCGTTCGAGGCGCGGGG	CCTGAGGCGGAGCCCCCGCTCTTCCGCCCCGC
CGGGCACTTCTCAGCCCCGCCGGCGTTTGAGGCGCGGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_030029668.1|2063540_2064683_-|glycosyltransferase-family-4-protein	unknown	unknown	gnl|CDD|340831
NZ_CP018870.1|WP_030037306.1|2046284_2046551_-|(Fe-S)-binding-protein	unknown	unknown	gnl|CDD|377304
NZ_CP018870.1|WP_045323323.1|2046724_2048077_-|3-deoxy-7-phosphoheptulonate-synthase-class-II	unknown	unknown	gnl|CDD|366662
NZ_CP018870.1|WP_075972025.1|2065903_2066968_-|hypothetical-protein	unknown	unknown	gnl|CDD|366353
NZ_CP018870.1|WP_030029669.1|2061624_2063421_+|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl|CDD|341233
NZ_CP018870.1|WP_075970155.1|2059989_2060430_-|SRPBCC-family-protein	unknown	unknown	gnl|CDD|176861
NZ_CP018870.1|WP_045323319.1|2050327_2050645_-|hypothetical-protein	unknown	unknown	gnl|CDD|259946
NZ_CP018870.1|WP_030036856.1|2053867_2054617_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|153251
NZ_CP018870.1|WP_075972024.1|2056356_2057118_-|endonuclease	unknown	unknown	gnl|CDD|226098
NZ_CP018870.1|WP_030028980.1|2057191_2058133_-|ROK-family-glucokinase	unknown	unknown	gnl|CDD|273246
NZ_CP018870.1|WP_075970156.1|2064703_2065843_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_078849159.1|2048418_2050359_+|phenazine-specific-anthranilate-synthase	unknown	unknown	gnl|CDD|223225
NZ_CP018870.1|WP_030036852.1|2055560_2056142_+|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NZ_CP018870.1|WP_030036861.1|2050727_2051756_-|6-phosphofructokinase	unknown	unknown	gnl|CDD|274155
NZ_CP018870.1|WP_075970153.1|2054785_2055568_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|224561
NZ_CP018870.1|WP_075970154.1|2058734_2059892_-|hypothetical-protein	unknown	unknown	gnl|CDD|223082
NZ_CP018870.1|WP_030028981.1|2058194_2058659_-|DUF5304-domain-containing-protein	unknown	unknown	gnl|CDD|375065
NZ_CP018870.1|WP_045323321.1|2051909_2052554_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP018870.1|WP_030029670.1|2060565_2061381_-|metallophosphoesterase	unknown	unknown	gnl|CDD|277338
NZ_CP018870.1|WP_078849158.1|2052613_2053840_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_030029668.1|2063540_2064683_-|glycosyltransferase-family-4-protein	gnl|CDD|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	4.0696e-69
NZ_CP018870.1|WP_030037306.1|2046284_2046551_-|(Fe-S)-binding-protein	gnl|CDD|377304	pfam04324, Fer2_BFD, BFD-like [2Fe-2S] binding domain. The two Fe ions are each coordinated by two conserved cysteine residues. This domain occurs alone in small proteins such as Bacterioferritin-associated ferredoxin (BFD). The function of BFD is not known, but it may may be a general redox and/or regulatory component involved in the iron storage or mobilisation functions of bacterioferritin in bacteria. This domain is also found in nitrate reductase proteins in association with Nitrite and sulphite reductase 4Fe-4S domain (pfam01077), Nitrite/Sulfite reductase ferredoxin-like half domain (pfam03460) and Pyridine nucleotide-disulphide oxidoreductase (pfam00070). It is also found in NifU nitrogen fixation proteins, in association with NifU-like N terminal domain (pfam01592) and NifU-like domain (pfam01106).	1.18062e-11
NZ_CP018870.1|WP_045323323.1|2046724_2048077_-|3-deoxy-7-phosphoheptulonate-synthase-class-II	gnl|CDD|366662	pfam01474, DAHP_synth_2, Class-II DAHP synthetase family. Members of this family are aldolase enzymes that catalyze the first step of the shikimate pathway.	0
NZ_CP018870.1|WP_075972025.1|2065903_2066968_-|hypothetical-protein	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	4.79532e-33
NZ_CP018870.1|WP_030029669.1|2061624_2063421_+|long-chain-fatty-acid--CoA-ligase	gnl|CDD|341233	cd05907, VL_LC_FACS_like, Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases. This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.	0
NZ_CP018870.1|WP_075970155.1|2059989_2060430_-|SRPBCC-family-protein	gnl|CDD|176861	cd07819, SRPBCC_2, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	1.98674e-53
NZ_CP018870.1|WP_045323319.1|2050327_2050645_-|hypothetical-protein	gnl|CDD|259946	cd13879, CuRO_2_McoP_like, The second cupredoxin domain of multicopper oxidase McoP and similar proteins. This family includes archaeal and bacterial multicopper oxidases (MCOs), represented by the extremely thermostable McoP from the hyperthermophilic archaeon Pyrobaculum aerophilum. McoP is an efficient metallo-oxidase that catalyzes the oxidation of cuprous and ferrous ions. It is noteworthy that McoP has three-fold higher catalytic efficiency when using nitrous oxide as electron acceptor than when using dioxygen, the typical oxidizing substrate of multicopper oxidases. McoP may function as a novel archaeal nitrous oxide reductase that is probably involved in the denitrification pathway in archaea. Although MCOs have diverse functions, majority of them have three cupredoxin domain repeats that include one mononuclear and one trinuclear copper center. The copper ions are bound in several sites: Type 1, Type 2, and/or Type 3. The ensemble of types 2 and 3 copper is called a trinuclear cluster. MCOs oxidize their substrate by accepting electrons at a mononuclear copper center and transferring them to the active site trinuclear copper center. The cupredoxin domain 2 of 3-domain MCOs has lost the ability to bind copper.	0.0077204
NZ_CP018870.1|WP_030036856.1|2053867_2054617_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	5.4852e-49
NZ_CP018870.1|WP_075972024.1|2056356_2057118_-|endonuclease	gnl|CDD|226098	COG3568, ElsH, Metal-dependent hydrolase [General function prediction only].	8.41816e-20
NZ_CP018870.1|WP_030028980.1|2057191_2058133_-|ROK-family-glucokinase	gnl|CDD|273246	TIGR00744, Glucokinase_Glucose_kinase., ROK family protein (putative glucokinase). This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General].	1.26768e-136
NZ_CP018870.1|WP_078849159.1|2048418_2050359_+|phenazine-specific-anthranilate-synthase	gnl|CDD|223225	COG0147, TrpE, Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism].	2.19601e-54
NZ_CP018870.1|WP_030036852.1|2055560_2056142_+|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00235878
NZ_CP018870.1|WP_030036861.1|2050727_2051756_-|6-phosphofructokinase	gnl|CDD|274155	TIGR02483, ATP-dependent_6-phosphofructokinase_1, phosphofructokinase. Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis].	0
NZ_CP018870.1|WP_075970153.1|2054785_2055568_+|alpha/beta-fold-hydrolase	gnl|CDD|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	5.98527e-39
NZ_CP018870.1|WP_075970154.1|2058734_2059892_-|hypothetical-protein	gnl|CDD|223082	COG0003, ArsA, Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning].	8.07519e-31
NZ_CP018870.1|WP_030028981.1|2058194_2058659_-|DUF5304-domain-containing-protein	gnl|CDD|375065	pfam17230, DUF5304, Family of unknown function (DUF5304). This family of unknown function is found in Actinobacteria.	3.12676e-49
NZ_CP018870.1|WP_045323321.1|2051909_2052554_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.27205e-64
NZ_CP018870.1|WP_030029670.1|2060565_2061381_-|metallophosphoesterase	gnl|CDD|277338	cd07392, MPP_PAE1087, Pyrobaculum aerophilum PAE1087 and related proteins, metallophosphatase domain. PAE1087 is an uncharacterized Pyrobaculum aerophilum protein with a metallophosphatase domain. The domain present in members of this family belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	5.3091e-14
NZ_CP018870.1|WP_078849158.1|2052613_2053840_-|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.7212e-26

Protein sequences

>NZ_CP018870.1|WP_030036852.1|2055560_2056142_+|hypothetical-protein
MAEHEEQSGGIPPLDEEAAWAAIVAGYGQEPPDPPGSRPFRPIENLALPEEDVKPLPAEPGAAPEPEPKPEPPAAPAPPLGSSVVFAPGVGMAGPRDHSLAEPDDEDPAAADEGHFVQPEPELPPADTTAKFAWLAVVGGPVLLLLAVLLQWDMTWWLTTLGIGGFLGGFATLVARMQHGDDEDDDPGRGAVV
>NZ_CP018870.1|WP_075970153.1|2054785_2055568_+|alpha/beta-fold-hydrolase
MVPVLPGAEPFRHEGGEVGVLLCHGFTGSPQSLRPWAEYLAERGLTVSLPLLPGHGTRWQDMQLTGWQDWYAEVDRALRELLDRCEQVFVFGLSMGGALTLRLAAKHGDAISGIVLVNPANKVHDPLAFALPVAQHFVRSTPGIVSDIARPGSVEVGYDRVPTRAAHSLRRFLRLVDAELPQVTQPLLLLHSPQDHVVPPVDSARVLARVSSTDVTETLLEQSYHVATLDHDAERIFADSFAFVGRLAESVGREGAEAGG
>NZ_CP018870.1|WP_030036856.1|2053867_2054617_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MKFSLGGSLKLAFRPWVEGIENVPAEGPAILASNHLSFSDSLFLPAVLDRKVTFIAKAEYFTSPGVKGRLTAAFFKGVGQLPVDRSGARGAGEAAIRSGIEVIERGELFGIYPEGTRSPDGRLYRGKPGGLARVALATGAPVIPVAMINTEKIQPPGKVIPKLMRPGIRIGKPLDFSRYHGMDNDRFILRSVTDEVMYEIMKLSGQEYVDIYATAAKRQIADAEKAAKDAEKAAKAARNDKGDNGGKSE
>NZ_CP018870.1|WP_078849158.1|2052613_2053840_-|sensor-histidine-kinase
MGEMAKRERVVRMSVEQPLWRALTAYRLLTMVYAVLLFASAYKLFPHPWPAAGYLTVLAVWTLATFRKVSNAASCTKGFLVADLAVAIAGVLLTPIVDTQERIASGGPTLPTIWTAGAVLGFAIKGGWRWACFASTFVAMANIVIHGGQPTRDTLHNVLLVWVASVAIGYVVEVARASENTLARALEIEAATRERERLARDIHDGVLQVLAMVQRRGAELGGEAEELGRMAGEQEVALRTLVSSGLVQPSRVCRDESRGALVDTYEDDEPGTDDGELDLRSLLAPHAGSRVSFAEPGTPVPLPVPAAKELAAAVGAALDNVRKHAGEGARAWILVEDWGDEVIVTVRDDGPGIPAGRLDQAEGEGRMGVALSIRGRLRDLGGSADLVSVPGQGTEVELKVPRGRTDKK
>NZ_CP018870.1|WP_045323321.1|2051909_2052554_-|response-regulator-transcription-factor
MVVDDHPMWRDAVARDLAAAGLDVVATAGDGPEAVRRARAVTPDVLVLDLNLPGMPGVQVCKELVGANPALRVLVLSASGEHADVLEAVKSGATGYLLKSAGAEELIDAVRRTAVGDPVFTPGLAGLVLGEYRRLATDPAPTASDEPKAPQLTDRETEVLRLVAKGLSYKQIAERLVISHRTVQNHVQNTLGKLQLHNRVELVRYAIEAGLDDA
>NZ_CP018870.1|WP_030036861.1|2050727_2051756_-|6-phosphofructokinase
MKVGVLTGGGDCPGLNAVIRAVVRKGHQEYGCEFIGFKDGWRGAVEGRTVPLDIPAVRGILPRGGTLLGSSRTNPFKTEHGVRDIKDNLAKYEVDALIAIGGEDTLGVAARLHQEYGIPCVGVPKTIDNDLSATDYTFGFDTAVGIATEAIDRLHTTAESHMRVLVVEVMGRHAGWIALHSGLAGGANVILIPEQRFDVDQVCAWVTSRFRASYAPIVVVAEGAMPKDGDMVLKDGTRDSFGHVRLSGVGEWLAKEIEERTGKEARTTVLGHIQRGGTPSAFDRWLATRFGLHAIDAVHEGDFGKMVALKGTDIVRVPIADATAKLKTVDPALYAEAGVFFG
>NZ_CP018870.1|WP_045323319.1|2050327_2050645_-|hypothetical-protein
MDIPSAVRWFLLAVAAVQLVHAVRALRPALRAAPGERVDAWLAFADPAVGAPVSVALAADHLTAFLCGMAVSGPVLAWQLIRSARASAANGRTPAATPGPVCGPL
>NZ_CP018870.1|WP_078849159.1|2048418_2050359_+|phenazine-specific-anthranilate-synthase
MEPSRQDIHSNSQDGPDHPRHPLSRLLDDSCPPFALLRRRTPGRDHDTVEVLLGPVHEAGRLADLPVGPLPTLALVPFRQIRERGFDVRDDGTPLIALVAEEVYEIPLARALAELPAHAVRVEGGGFDVRDEAYAETVERVVRDEIGRGEGANFVIRRTFGGRIDGFGRADALALFRRLLEGERGAYWTYVVHTGERTLVGASPEVHVRMSGGTVVMNPISGTYRHPSTGPTAESLLSFLGDRKETEELSMVVDEELKMMCTVGDRGGVVVGPRLKEMSHLTHTEYELRGRSSLDVREVLRETMFAATVTGSPVQNACRVIERYEAGGRGYYAGALALLGLDAAGAQTLDSPILIRTADIGADGTLRVPVGATLVRHSDPAGEVAETHAKAAGVLAALGVRPAAPRAAAERARLADDPRVRAALAARRADLAPFWLRMQERPAAATGRALVVDGEDTFTAMLAHVLRVAGLEVAVRRFDEPGLREAALAWEGPVVLGPGPGNPADGGDPKMRMLRGLAAELLAGHRHGLLGVCLGHELLAAELGLPLVRKAEPAQGAQTRIGLFGAEEVVGFYNTYTAHCDEAGAARLARAGVEVSRDPVTGEVHALRSAGGGFAGVQFHPESVLTLRGADLLRDLLTAVRTPAPA
>NZ_CP018870.1|WP_045323323.1|2046724_2048077_-|3-deoxy-7-phosphoheptulonate-synthase-class-II
MTVNAETQAPAAKATWRDLPAAQQPSYPDAEALRAVVADLESYPPLVFAGECDQLRARLGAVAKGEAFLLQGGDCAEAFDGVSADHIRAKLKTLLQMSAVLTYAASVPVVKVGRIAGQYSKPRSKDTETRDGVTLPTYRGDSVNGFAFTEEARVPDPERLKRMYNASASTLNLVRAFTTGGYADLRQVHAWNQDFVKSSPSGQRYEQLAREIDNALNFMKACGTDPAEFKAVEFYASHEALLLDYEGALTRTDSRTGKLYDTSGHMVWIGERTRQLDHAHIEFCSQIANPIGIKLGPTTTVDEALTYIDRLDPEREPGRLTFVVRMGADKVRDKLPELVEKVTASGAIVGWVSDPMHGNTFEAASGHKTRRFDDVLDEVKGFFEVHKGLGTHPGGIHVELTGDDVTECVGGGDEIFVDDLHQRYETACDPRLNRSQSLDLAFLVAELYRD
>NZ_CP018870.1|WP_030037306.1|2046284_2046551_-|(Fe-S)-binding-protein
MNRVYVCSCFGITDKQVKEHAAAGACTPRQIASATKAGTDCGSCVRTIQGILGRGACPRRELLEKGDAVSVLAADTEAVRSPAMAEAA
>NZ_CP018870.1|WP_075972024.1|2056356_2057118_-|endonuclease
MDQLPPPLPKSRTEPDGSAVIRVLGYNVRSLRDDEEALVRVIRACEPDLVLVQEAPRFFRWRKHAARLARKCDLVVLGGGATATGPLLLCSLRVFAERTRDVLLPHTPGLHRRGLATAVVRIGGVRVGVVSAHLSLDREQRRAQAGLVLDGLSALDTPYGIVAADVNEGPDGPAFGRLAAVLQDCRAVAPWGGEGTFPAVAPDRRIDAVFATAGVEVLACGVPAGLAGVSDGDLRSATDHLPVLAVLRLPAAG
>NZ_CP018870.1|WP_030028980.1|2057191_2058133_-|ROK-family-glucokinase
MGLTIGVDIGGTKIAAGVVDEEGTILETYKVPTPPTADGVTEAICAAVSEVSSNHTIEAVGIGAAGYVDDKRATVLFAPNINWRHEPLKDKVEQRIGLPVVVENDANCAAWGEYRFGAGQGHEDVICITLGTGLGGGIIIGNKLRRGRFGVAAEFGHIRVVPDGLLCGCGSQGCWEQYASGRALVRYAKQRANATPENATILLALGDGTPDGIEGKHISEAARQGDLVAVDAFRELARWAGAGLADLASLFDPSAFIVGGGVSDEGDLVLDPIRKSFKRWLVGGAWRPHAQVLAAQLGGKAGLVGAADLARQG
>NZ_CP018870.1|WP_030028981.1|2058194_2058659_-|DUF5304-domain-containing-protein
MSEATDRPTDDDAWAKACAEDLAAEKERLRGQDRTGTGATGTAAEELFKLFEAVADKVSGLNNPLFGAAAQGAVRQIFDQAKTAAKPVVERNPEVFDHLAAAGSELLAAYRSAVEGHEGRWTRGEPRAPRQAPDDRDPRRDGPDDGPAERIDLD
>NZ_CP018870.1|WP_075970154.1|2058734_2059892_-|hypothetical-protein
MHTLLVTGPGGAGRTTVAAATALAAARRGRQVLLLTGDAGDPLAALLGDPLPPGLSTARVDSGQEFRDELVTLQERGSALLSMVGARPLAAEELTELPGAEQFALLRALRRAATAPAADLVVADLPPIHQAVATLALPAQLRRYLARLLPAEKQAARALRPVLAQLAGVPMPAQWLYEAAARWDQELAAVQAVIEADTTAVRLVAEPGPAADDALRLGRLGLALHQLPVHDVVANRTVPPGSADPWLAGLAAQQEKYAAEWAGEGPVTTLAHLGPDPQGQDDLDRLGATAALLPDRPAPRRAWTVEDRLADDGVLVWVVPLPGAHKRDLDLVRRGDELLLTAGPHRRIVTLPSALRRCTVSGAALTEGELRIRFTPDPGLWPRTR
>NZ_CP018870.1|WP_075970155.1|2059989_2060430_-|SRPBCC-family-protein
MAEHTSSSITINATPGAVMAVIADFARYPEWTGEVKEAEVLATNADGRAEKVRLLLDAGAIKDDHTLAYTWKGTDEVSWTLDKSQMLRQLDGSYRLTPVDGGAHTEVTYQLTVDVKIPMLGMIKRKAEKVIIDRALAGLKKRVESV
>NZ_CP018870.1|WP_030029670.1|2060565_2061381_-|metallophosphoesterase
MAGSTRGGKNGTSGSSRTRVHVVSDVHGNTEALARAGDGADALICLGDLVLFLDYADHSRGIFPDLFGVENADLIVELRTQRRFDEAHALGRRLWAGLDREQVIEDAVRRQYAQMFAAFPRPTYATYGNVDIPTLWPEYADRHGLTVLDGQRVEIAGRVFGFVGGGLPSPMRTPYEVDVEEYAAKVEALGEVDVLCSHIPPEVPELCYDTVARRFERGSEALLAAIRRTRPRYALFGHVHQPLTRRMRIGATECVNVGHFASTGRPWAMEW
>NZ_CP018870.1|WP_030029669.1|2061624_2063421_+|long-chain-fatty-acid--CoA-ligase
MREFSLPALYEVPSDGNLTDLIRRNAAQHPDTAVMSRKADGRWQDVTATEFLAEVRATAKGLIAAGVRPGDRVALISRTRYEWVLIDFAIWSAGGVTVPVYETSSPEQIQWILGDSGAVAAVVESPGHSKAVASLRESLPELRDVWEIEQGALDTLKAAGAAVTDAEVDERSSLANADDPATIVYTSGTTGRPKGCVLSHRNFFAECGNAVERLSPLFRTGECSVLLFLPAAHVFGRLVEVAAVLAPIRLGCVPDIKNLTEELQSFRPTLILGVPRVFEKVYNSARAKAQAEGKGKIFDAAADTAIAYSRALDTPRGPSFGLKLKHKLFSKLVYSKLHAVLGGRGEYAISGGAPLGERLGHFFRGIGFTVLEGYGLTESCAATTFNPWDKQKIGTVGQPMPGSVVRIADDGEVLLHGEQIFTGYWKNEAATAEALTDGWFHTGDVGTLDEDGYLTITGRKKELIVTAGGKNVAPAVIEDRIRAHALVAECMVVGDARPFVAALVTIDEEFLGRWAAENGKPAGVTAAELREDADLVAAVQKAIDDGNAAVSKAESVRKFRILPSQFTEESGHITPSLKLKRNVVAKDYADEIEALYRG
>NZ_CP018870.1|WP_030029668.1|2063540_2064683_-|glycosyltransferase-family-4-protein
MHKTLIVTNDFPPRPGGIQAFLHNMALRLDPDRVVVYASTWKHGAEGREATAAFDAEQPFQVVRDRTTMLLPTPRVTRRAVGLLREHGCESVWFGAAAPLGLMGPALRRAGARRIVATTHGHEAGWAQLPAARQLLRRIGEGTDTLTYLGEYTRSRIASAVTDRAAARMVQLPPGVDEKTFHPASGGDDVRARLGLTDRPVVVCVSRLVPRKGQDTLIEAMPRILAAVPDAVLLIVGGGPYEDDLRALAASTGVARSVVFTGAVPWSELPAHYGAGDVFAMPCRTRRGGLDVEGLGIVYLEASATGLPVVAGDSGGAPDAVLDGETGWVVRGGAPEEAADRITALLRDPGLRARMGERGRAWVEEKWRWDLLAERLRELL
>NZ_CP018870.1|WP_075970156.1|2064703_2065843_-|hypothetical-protein
MPRLRRPPRIRPLLPVLPVLLCALLAGCGPGPAGGADTAERDVRRAVADWSRQTPDALAGIPFADRVYEVASVRRDGERALVRARLRYRLAGYDTAPEESAREIEAVRQGGTWRVSADRPAPGALPQLWDQGAVSVAAGTHSLVLGGAGQSTATLEEIAAEADRAVPAATAAWPGPWAGRVVVLVPGSLDAMARLLGRPADAYRALGAVTTGRVGDGPAPADRVVVNPEGYAGLGAEGRRIILAHEVTHVATRTATAAATPLWLSEGFADWAAYRGASTSPAQAAPALARAVRDGALPGQLPGTEDFAFGGDPEAAARAYEGAWLACRLIAAKWGEKALVDLYARAGREPLETALRETLGVDRAGLTEAWRDSLREELR
>NZ_CP018870.1|WP_075972025.1|2065903_2066968_-|hypothetical-protein
MASHRRSGLGGLDRSAKATVLTAAAATAAVAMAGVPANAAPGLPYEPGGGARSGVSAQVDRLFEEAEQATEHFNEAGEKAARLRTEVNRAQDAVARGQERINTMRGILGTFAGAQYRSGGIDPAVGLMLAEDPDAYLAQAAALDRLTERQARHLHELRQEQRRLGQVRAEASRKLAELDALRSDVARHKRSVTEKLAAARRLLNSMPSQERADFERSSRSGGRHEAMPDLGPLDAGGAPSGRAAAAVMAARAAVGRPYVWGSTGPSGFDCSGLMVWSYRQAGVSLPRTSQAQRHAGRQVPLSQARPGDLVTYRSDASHVGMYVGNGQVVHAPYPGARVRYDPVGMMPVSAVTRP

Crispr_ID: NZ_CP018870_8

• CRISPR_ID: NZ_CP018870_8
• CRISPR_location: 2135557-2135632
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_8

Consensus_repeat	Method
GCGCGGGGCCCGGGGCGGAGCCCCG	CRISPRCasFinder

spacers of NZ_CP018870_8

>8.1|2135582|26|NZ_CP018870|CRISPRCasFinder
CTCTTTCAGCCCCGCCGGCGCTTGAA

CRISPR arrays and Neighbor proteins around NZ_CP018870_8

CRISPR arrays

The CRISPR arrays of NZ_CP018870_8

>merge|NZ_CP018870|8|2135557-2135632|CRISPRCasFinder
GCGCGGGGCCCGGGGCGGAGCCCCGCTCTTTCAGCCCCGCCGGCGCTTGAAGCGCGGGGCCCGGGCCGGAGCCCCG

>NZ_CP018870|8|7|2135557-2135632|CRISPRCasFinder
GCGCGGGGCCCGGGGCGGAGCCCCG	CTCTTTCAGCCCCGCCGGCGCTTGAA
GCGCGGGGCCCGGGCCGGAGCCCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_030031546.1|2132981_2134253_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|366721
NZ_CP018870.1|WP_030031245.1|2130098_2130890_-|lipoyl(octanoyl)-transferase-LipB	unknown	unknown	gnl|CDD|184638
NZ_CP018870.1|WP_075970168.1|2131459_2132899_+|regulator	unknown	unknown	unknown
NZ_CP018870.1|WP_045323172.1|2124107_2124761_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|188483
NZ_CP018870.1|WP_030030928.1|2128448_2128646_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030032820.1|2138064_2138436_+|arsenate-reductase	unknown	unknown	gnl|CDD|239332
NZ_CP018870.1|WP_030030927.1|2127739_2128438_-|DUF4191-domain-containing-protein	unknown	unknown	gnl|CDD|379389
NZ_CP018870.1|WP_030031547.1|2134409_2135297_-|TIGR01777-family-protein	unknown	unknown	gnl|CDD|273800
NZ_CP018870.1|WP_030030925.1|2125581_2126991_-|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl|CDD|273198
NZ_CP018870.1|WP_045322285.1|2141448_2142378_-|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NZ_CP018870.1|WP_107484760.1|2139343_2140243_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP018870.1|WP_030030019.1|2142591_2143611_+|glutamine-synthetase	unknown	unknown	gnl|CDD|177922
NZ_CP018870.1|WP_030032818.1|2137706_2137958_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030030926.1|2127176_2127644_+|RDD-family-protein	unknown	unknown	gnl|CDD|377640
NZ_CP018870.1|WP_079273155.1|2138462_2139293_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|372616
NZ_CP018870.1|WP_079273431.1|2140428_2140785_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_CP018870.1|WP_045322294.1|2135654_2136326_-|VIT-family-protein	unknown	unknown	gnl|CDD|153123
NZ_CP018870.1|WP_075972030.1|2140979_2141438_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075972026.1|2136535_2137588_+|serine/threonine-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NZ_CP018870.1|WP_037927122.1|2129025_2129979_-|lipoyl-synthase	unknown	unknown	gnl|CDD|235493

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_030031546.1|2132981_2134253_-|FAD-dependent-oxidoreductase	gnl|CDD|366721	pfam01593, Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	1.04727e-34
NZ_CP018870.1|WP_030031245.1|2130098_2130890_-|lipoyl(octanoyl)-transferase-LipB	gnl|CDD|184638	PRK14345, PRK14345, lipoyl(octanoyl) transferase LipB.	2.547e-110
NZ_CP018870.1|WP_079273431.1|2140428_2140785_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.45092e-08
NZ_CP018870.1|WP_045323172.1|2124107_2124761_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	8.20423e-14
NZ_CP018870.1|WP_030030019.1|2142591_2143611_+|glutamine-synthetase	gnl|CDD|177922	PLN02284, PLN02284, glutamine synthetase.	4.22217e-161
NZ_CP018870.1|WP_107484760.1|2139343_2140243_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.23474e-13
NZ_CP018870.1|WP_030030927.1|2127739_2128438_-|DUF4191-domain-containing-protein	gnl|CDD|379389	pfam13829, DUF4191, Domain of unknown function (DUF4191).	9.15211e-107
NZ_CP018870.1|WP_030031547.1|2134409_2135297_-|TIGR01777-family-protein	gnl|CDD|273800	TIGR01777, Hypothetical_UPF0105_protein_Rv2216/MT2273/Mb2239., TIGR01777 family protein. This model represents a clade of proteins of unknown function including the E. coli yfcH protein. [Hypothetical proteins, Conserved].	5.92918e-122
NZ_CP018870.1|WP_030030925.1|2125581_2126991_-|type-I-glutamate--ammonia-ligase	gnl|CDD|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0
NZ_CP018870.1|WP_045322285.1|2141448_2142378_-|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.94923e-29
NZ_CP018870.1|WP_030032820.1|2138064_2138436_+|arsenate-reductase	gnl|CDD|239332	cd03034, ArsC_ArsC, Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.	1.16141e-37
NZ_CP018870.1|WP_030030926.1|2127176_2127644_+|RDD-family-protein	gnl|CDD|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	4.78071e-11
NZ_CP018870.1|WP_079273155.1|2138462_2139293_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	9.54756e-25
NZ_CP018870.1|WP_045322294.1|2135654_2136326_-|VIT-family-protein	gnl|CDD|153123	cd02432, Nodulin-21_like_1, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	6.3235e-97
NZ_CP018870.1|WP_075972026.1|2136535_2137588_+|serine/threonine-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.46606e-37
NZ_CP018870.1|WP_037927122.1|2129025_2129979_-|lipoyl-synthase	gnl|CDD|235493	PRK05481, PRK05481, lipoyl synthase; Provisional.	0

Protein sequences

>NZ_CP018870.1|WP_030031547.1|2134409_2135297_-|TIGR01777-family-protein
MRIAITGSTGLIGSALVRSLRADGHEVVRFVRREPAGAGEAGWDPERGHVDRAALAGCGAVVHLAGAGIGDHRWTAAYKRKIRDSRVLGTAALAHALAGLDEPPGVLVSGSAVGYYGDTGDRVVDEDAPAGQGFLPSVCVEWEAAAAPAREAGIRTAYARTGLVVAKEGGAWGRMFPLFRAGVGGRLGDGRQYWPFISLHDQVAALRHIIDTPDLHGPVNLTAPEPLTNRQVTAAMARVLRRPAVLPVPAVALRVVLGELSEDVLAGQRARPARLLESGFVFRDPGIEQAIRAAL
>NZ_CP018870.1|WP_030031546.1|2132981_2134253_-|FAD-dependent-oxidoreductase
MLSSAPNAAHHADVVIVGAGVSGLAAAHHLIAAGVTVTVLEAADGPGGRMATETADGFRLDRTAPLLNTAYSELERTHALRALVLRPFTPGVLVHTDGRQLRAGSLTPARALASGSLDQARLSAALGRLAALPEDKLLARPERTASAALRTRGLPQRTLGGVLRPLLAALLRDPDLTTSSRVADLALRTFARGRLAVPEGGAGALPDLLASGLPPGTVRTGIRVRSVATNLVTTEEHGDFRCRSVLLATGARAAAELLPGLRVPAFHEVTVLHHATAGTLPRDGSLILDGDPNWPVSHTAVMSAVDPTRAPAGRSLVTTTVLGPPPPVRTVASRLARLYDTPTREWELLAVHHTPEAVPAMPPPHDRRRPVRVLAGLYVCGDHRDTNTAEGALHSARRAAGAILRDFGIPLPVAPEPALPVAA
>NZ_CP018870.1|WP_075970168.1|2131459_2132899_+|regulator
MTERPAQRVPNRQLAALIAEAGFSNAGLARRVDQLGLEHGLDLRYDKTSVTRWLRGQQPRGTTPALIAEVFTRRLGRRLSAQDLGLDACAPVYAGLEFAATPEEAVDIASGLWRKDSGSHAELRKIAFTPAGLVVPSRDWLIGRPDERVARGAEPAAARVPLQGRATVPRQRQIDRSPGQRVTAGDIGALRSVGELFRTLDHAYGGGHARQALVRYLEHEAEPMLRGTYGETTGRRLFAAAADLTRLAGWTSYDIAAHGLAQRYFVQALRLAQAAGDRPYGSYVLVTMSRQAVYLGHGREAVQLARVAQQGVGSGPPPVVQAMLHSAEARGHAVLGEVRAATACLVRAERALGAARPGDDVPHWARLFDEAQLADEFGHCHRDLQQYRASAQHAERSLQLRAPGFARSRLFCRVVLATARLGLGELDQACALGAEAAQQAMEMRSVRAVEYVRDFERRLEPYRDAAAVRTYRDRVAALS
>NZ_CP018870.1|WP_030031245.1|2130098_2130890_-|lipoyl(octanoyl)-transferase-LipB
MAELGFVRLGFGAEAVEYTQAWEEQRRVHAARFADEIGDTCLLLEHPPVYTAGRRTDPSERPLDGTPVVDVDRGGKITWHGPGQLVGYPIMKLPRPVDVVAHVRRLEEALIRTAAEFGLETTRVEGRSGVWVLGDPVEERPKIGGLSLEFDPRLHDEEFDARLNGPEYAPSNAGQRREDRKLAAIGIRVAKGVTMHGFAINVNPDSTWFDRIIPCGIRDAGVTSLSYELGREITIAEVLPVAERHLKDVLEHAELRPREIETA
>NZ_CP018870.1|WP_037927122.1|2129025_2129979_-|lipoyl-synthase
MSAVAPDGRKMLRLEVRNAQTPIERKPEWIKTRAKMGPEYTKMQALVKGEGLHTVCQEAGCPNIYECWEDREATFLIGGDQCTRRCDFCQIDTGKPEALDRDEPRRVGESVVTMDLNYATITGVARDDLADGGAWLYAETVRQIHQQTAGREAGHTKVELLAPDFNAVPELLEEVFASRPEVFAHNVETVPRIFKRIRPGFRYERSLEVITKARAYGLVTKSNLILGMGEEREEVSQALKDLHEAGCELITITQYLRPSPRHHPVERWVKPAEFVELAKEAEEIGYSGVMSGPLVRSSYRAGRLYQQAMEKRSGAVA
>NZ_CP018870.1|WP_030030928.1|2128448_2128646_-|hypothetical-protein
MQAAPVRAIAIPTLSDAFRGIESLLMSGARRNAWTAVLEDRKRARDRVETEHVLEAAATRTPQAT
>NZ_CP018870.1|WP_030030927.1|2127739_2128438_-|DUF4191-domain-containing-protein
MARKSNAETAANPGRLKQIALTYKMTRKADPKVGLIVAGVGIVTFGVFLAIGFLIDHPVYLGILGFLVAFLAMAIVFGRRAERAAFGQMEGQPGAAAAVLDNVGRGWTTTPAIAMTRQQDIVHRAVGKAGVVLIAEGNPNRVKPLLANEKKKMARIMPDVPVHDFIVGTGEGEVPLKKVRTTLLKLPRVLSGPQITQVNDKLRAMGDLMSNMPLPKGPMPKGMRMPRGGKMR
>NZ_CP018870.1|WP_030030926.1|2127176_2127644_+|RDD-family-protein
MDNRQAIGSWLSGPKAAAEEMGVEFGYPGQRLGLPQEGPGSVARFGRRIAAVALDWIGCQLIAYGLITGGNLGAAGNWTLGLFLALTILTVGTVGFTPGKRALGLRVVAEDGGRLGIVRVVVRTLLLALFIPALIWDRDGRGLHDRLARAVQVRI
>NZ_CP018870.1|WP_030030925.1|2125581_2126991_-|type-I-glutamate--ammonia-ligase
MFQNADEVKQYIEENDVKFVDVRFCDLPGVMQHFTIPARAFDPAEELAFDGSSIRGFQAIHESDMALRADITTARLDPFRRDKTLNINFFIHDPITGEAYSRDPRNIAKKAEAYLASTGIADTAFFGPEAEFYIFDSVRFATTANEGFYHIDSEAGAWNTGSEENNRGYKVRYKGGYFPVAPVDHFADLRAEISLELDAQGLQVERQHHEVGTGGQAEINYKFNTLLAAADDLMLFKYIVKNVAWKNGKTATFMPKPIFGDNGSGMHVHQSLWAGGEPLFYDEAGYAGLSDTARYYIGGILKHAPSLLAFTNPTVNSYHRLVPGFEAPVNMVYSQRNRSAAMRIPITGSNPKAKRVEFRAPDPSSNPYLAFSALLLAGLDGIKNKIEPMEPIDKDLYELSPDEHANVPQVPTSLEDVLKALEEDHEYLLAGGVFTPDLIETWIDYKRTHEIAPIAQRPHPHEFELYFDL
>NZ_CP018870.1|WP_045323172.1|2124107_2124761_+|TetR/AcrR-family-transcriptional-regulator
MNSPRPYAPQAGPGAPSLTERRKAATQLDIARAACELFAEHGPDATTAEDIAHRAGVALRTFYRYFRNKQEAVAPLLAGGGDAWRALLAEEEPGAPLAPALERAVTRSLSAPQAVEEGLEVTRGLLRAAADDQALRAVWYRVNQESEEGLVPVIGRLAGPGADPRQVRLLAAAATDAIRVALELWASTDAPVSGPGSPAELAVLCLRDLTAAMPLLR
>NZ_CP018870.1|WP_045322294.1|2135654_2136326_-|VIT-family-protein
MSTRLNWLRAGVLGANDGIISTAGLVVGVAGSTTSRATILAAGVAGLLAGSLSMAAGEYVSVSSQRDSERAALDMERRELAEEPEAELDELTDLLAQRGLSRDVAREAAEQLTERDALRAHARVELGINPDELANPWHAAFASLVAFTVGALLPLLAIVLPGPSARVPVTVVAVLGALTLCGVLSARLGGAPVARAVARNVAGGALAMAVTYAVGTWLGAATA
>NZ_CP018870.1|WP_075972026.1|2136535_2137588_+|serine/threonine-protein-phosphatase
MRTEPPPRWARIAPAAALLALVLAQALTSDVELGFFLAGLPPVAAFAYGAAGTAAFAAIVLLLLGVHDIGVAQARGTDLATVAVVGLLSVVIAWVRQRRDEQLVSVRTVAEAAQLAVLPPVPDRVGAVRCSGLYRAAQRGTLVGGDLYDVRVGPFGVRALVADVQGHGLAAVATVAGLLGAFREAVLDDTELAAVVARLDRRLLADTADAHADHPELFATAVLVEFPPGLDVVRFVSCGHPPALRLRGAAVEEVSVEPGPPLGLGLAGPDPPKVVELPVLPGDRFLLHTDGATEARDTAGHFYPLATRVPVLARDPAGLVGAVWRDLSAFTKGGPGDDVALLLLSPDGRQ
>NZ_CP018870.1|WP_030032818.1|2137706_2137958_-|hypothetical-protein
MATASTVRPVQKKPLPAGLPREWYESHNRRLKAMRLAISLLDSGTYDAKRATNRKIRTMAVRTGIHRPSNVTCKMVRAFIKES
>NZ_CP018870.1|WP_030032820.1|2138064_2138436_+|arsenate-reductase
MEIWINPACSKCRSALTLLDAEGAEYTVRRYLEDVPSEDEIREVLGRLGLEPWDITRTSDPLAKETGVRDLPREETDAARALWISHLAAHPKLIQRPIITAEDGTAVVARSEEAVRDALSRNA
>NZ_CP018870.1|WP_079273155.1|2138462_2139293_-|class-I-SAM-dependent-methyltransferase
MSAGPAFAAPSATVPLASPQPRLLYDACPLCSDGDISVLRTGDCSRHPLYKPVVAPVMTWMRCAACGHVFTDGYFSDEVSAEIFSATNPNQQPGAGFEQNRYTSARIVERVARHVPDGRWLDVGFGNGSLLFTAEEWGFEPQGLDLRPSTAEGLRRLGIEAHCADLTALDAPGRYSVISLADVLEHMPYPGQGLAAAHRLLRDGGVVFASMPNYDCSVWRLLDAGEANPYWGELEHFHNFSRRRLYQLMEEHGFEPLHYAVSERYRACMEVIARRA
>NZ_CP018870.1|WP_107484760.1|2139343_2140243_-|alpha/beta-hydrolase
MSSPSPSSSSFRSTRHCATASFRAAYDQVLGGWPGPVEAVDLPTPCGVTRVNSCGPVDAPPLVLLPGGGATSAVWGACAAAGAARTHRVHAVDLPGEPGLSAPDPERPPRTADDLTGWLDAVLEGIDPRGAVTLCGHSYGAWIAAHHAVRGAAGLGRLVLLDPTQVFAGLRPGYVLRALPMLLRPSPRRIRSFLAWETGGAALDPAWLRLQDETARFPAARPVTGPRPDLGRLAQPPTGRAGVRVDVLFAGRARCHDPHRAARAAREALPDARVDVLPGVSHHSLPLAAAPEIARLLAG
>NZ_CP018870.1|WP_079273431.1|2140428_2140785_+|MarR-family-transcriptional-regulator
MHPTDVRALICLLDADRAAEPATAGLLGARLGLNSAGTTAVIDRLERLGHVARIRDEQDRRRILLRVEPAAIRLGREFFGPLIDGVLRVLDSFDPAERDTVRRFLTATHAAFASEPHR
>NZ_CP018870.1|WP_075972030.1|2140979_2141438_+|hypothetical-protein
MFGGVYGTILASGLLAALDQKGDDFTPYYDASWVIVTAATAGLAHGYAHHMASHDQGSAGHRWRLLVVALWNEWPLIVAALPTVLLLVVSGIFDWDSYGVTAVGLGLNTALLFAWGSVVALRVGYRFGSALLIGLADATIGLAIIVANALIK
>NZ_CP018870.1|WP_045322285.1|2141448_2142378_-|Gfo/Idh/MocA-family-oxidoreductase
MSPAGDPAEPAAAAPRPRVGLLGTGPWAHRTHAPALAAHTGSDFAGVWGRRPEAAAELADAYGVKVYEDPDALFADCDVAAFALPPDVQAPLALRAAAAGCHLLLDKPVATTSEDARAVADAVARHGVASVVFLTLRFAEPTAGWVAEQAARAGWFTAAAHWLGAVFPPDGSPSAYADSPWRKDKGGLWDVGPHALSVLIPILGDVTEVSATRGPSDVVQLALRHASGAASTAVLSLGAPQAAAGVGLELRGTEGVHELPGWSDVPGAYGRALDALLTAARTGVPDPRGAEFGARLTEILAQAEAQLPV
>NZ_CP018870.1|WP_030030019.1|2142591_2143611_+|glutamine-synthetase
MSYKAEYIWIDGTEPTAKLRSKTKILADGAELPIWGFDGSSTNQAEGHASDRVLQPVFSCPDPIRGGDNVLVLCEVLNIDMTPHESNARALLRPVAEKFAGQEPIFGIEQEYTFFDGARPLGFPVGGFPAAQGGYYCGVGSDEIFGREIVEKHLDHCLAAGLSISGINAEVMPGQWEFQVGPVGPLEVSDQLWIARWLLYRTAEDFNVSATLNPKPVKGDWNGAGAHTNFSTKAMREDYRAIISACEALGEGSKPLDHVKNYGAGIDERLTGLHETAPWNEFSYGVSDRGASVRIPWQVEKDGKGYIEDRRPNANVDPYVVTRLITDTCCTGLEKDGLA

Crispr_ID: NZ_CP018870_9

• CRISPR_ID: NZ_CP018870_9
• CRISPR_location: 2256548-2256644
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_9

Consensus_repeat	Method
CCGCCGGTGTCACCGCTGTACGAGG	CRISPRCasFinder

spacers of NZ_CP018870_9

>9.1|2256573|47|NZ_CP018870|CRISPRCasFinder
CCTTCTGCCAGGTCAGGGACCCGAGCGGGGCGCACTCGACGCACTGA

CRISPR arrays and Neighbor proteins around NZ_CP018870_9

CRISPR arrays

The CRISPR arrays of NZ_CP018870_9

>merge|NZ_CP018870|9|2256548-2256644|CRISPRCasFinder
CCGCCGGTGTCACCGCTGTACGAGGCCTTCTGCCAGGTCAGGGACCCGAGCGGGGCGCACTCGACGCACTGACCGCCGGTGTCACCGCTGTACGAGG

>NZ_CP018870|9|8|2256548-2256644|CRISPRCasFinder
CCGCCGGTGTCACCGCTGTACGAGG	CCTTCTGCCAGGTCAGGGACCCGAGCGGGGCGCACTCGACGCACTGA
CCGCCGGTGTCACCGCTGTACGAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_075970206.1|2265155_2266166_+|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274647
NZ_CP018870.1|WP_075970200.1|2251390_2253523_-|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173841
NZ_CP018870.1|WP_052680546.1|2248094_2248457_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP018870.1|WP_075970199.1|2247034_2247889_-|3-alpha,7-alpha,-12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA-hydratase	unknown	unknown	gnl|CDD|178455
NZ_CP018870.1|WP_045322030.1|2266772_2267411_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075970205.1|2262435_2265033_+|peptidoglycan-recognition-protein	unknown	unknown	gnl|CDD|128941
NZ_CP018870.1|WP_052680547.1|2249208_2249505_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075970203.1|2256646_2257495_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|379262
NZ_CP018870.1|WP_075972037.1|2267523_2267826_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030029855.1|2259539_2260181_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379276
NZ_CP018870.1|WP_075970204.1|2257605_2259429_+|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP018870.1|WP_045322012.1|2245920_2246997_-|Zn-dependent-alcohol-dehydrogenase	unknown	unknown	gnl|CDD|176240
NZ_CP018870.1|WP_158879932.1|2266233_2266617_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030029859.1|2261440_2262262_+|membrane-protein	unknown	unknown	gnl|CDD|236090
NZ_CP018870.1|WP_030030103.1|2248649_2249195_+|RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|224511
NZ_CP018870.1|WP_075970201.1|2253724_2254741_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075970202.1|2254792_2256385_-|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP018870.1|WP_045322015.1|2249514_2250000_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030029857.1|2260285_2261284_+|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl|CDD|119407
NZ_CP018870.1|WP_045322019.1|2250187_2251375_-|lipid-transfer-protein	unknown	unknown	gnl|CDD|181327

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_075970206.1|2265155_2266166_+|LLM-class-F420-dependent-oxidoreductase	gnl|CDD|274647	TIGR03559, F420_Rv3520c, probable F420-dependent oxidoreductase, Rv3520c family. Members of this protein family are predicted to be oxidoreductases dependent on coenzyme F420. The family includes a single member in Mycobacterium tuberculosis (Rv3520c/MT3621) but four in Mycobacterium smegmatis. Prediction that this family is F420-dependent is based primarily on Partial Phylogenetic Profiling vs. F420 biosynthesis. [Unknown function, Enzymes of unknown specificity].	8.96858e-167
NZ_CP018870.1|WP_075970200.1|2251390_2253523_-|acyl-CoA-dehydrogenase	gnl|CDD|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	1.99764e-108
NZ_CP018870.1|WP_052680546.1|2248094_2248457_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.00848e-09
NZ_CP018870.1|WP_075970199.1|2247034_2247889_-|3-alpha,7-alpha,-12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA-hydratase	gnl|CDD|178455	PLN02864, PLN02864, enoyl-CoA hydratase.	2.01301e-72
NZ_CP018870.1|WP_075970205.1|2262435_2265033_+|peptidoglycan-recognition-protein	gnl|CDD|128941	smart00701, PGRP, Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine.	7.5714e-36
NZ_CP018870.1|WP_075970204.1|2257605_2259429_+|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.68414e-95
NZ_CP018870.1|WP_075970203.1|2256646_2257495_-|helix-turn-helix-domain-containing-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	3.70213e-05
NZ_CP018870.1|WP_045322012.1|2245920_2246997_-|Zn-dependent-alcohol-dehydrogenase	gnl|CDD|176240	cd08279, Zn_ADH_class_III, Class III alcohol dehydrogenase. Glutathione-dependent formaldehyde dehydrogenases (FDHs, Class III ADH) are members of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. Class III ADH are also known as glutathione-dependent formaldehyde dehydrogenase (FDH), which convert aldehydes to corresponding carboxylic acid and alcohol. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of an beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding.	1.09381e-155
NZ_CP018870.1|WP_030029859.1|2261440_2262262_+|membrane-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.00046061
NZ_CP018870.1|WP_030030103.1|2248649_2249195_+|RNA-polymerase-sigma-factor	gnl|CDD|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	6.74462e-27
NZ_CP018870.1|WP_075970202.1|2254792_2256385_-|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.41901e-83
NZ_CP018870.1|WP_030029855.1|2259539_2260181_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|379276	pfam13578, Methyltransf_24, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.75243e-22
NZ_CP018870.1|WP_030029857.1|2260285_2261284_+|N-acetylmuramoyl-L-alanine-amidase	gnl|CDD|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	3.0179e-39
NZ_CP018870.1|WP_045322019.1|2250187_2251375_-|lipid-transfer-protein	gnl|CDD|181327	PRK08256, PRK08256, lipid-transfer protein; Provisional.	0

Protein sequences

>NZ_CP018870.1|WP_075970202.1|2254792_2256385_-|serine/threonine-protein-kinase
MEQVEPGGPTRVGPFEVVGVLGRGGMGRVLLGAGPDGRLVAVKQVLAQFADDEGFRARFRREVTASRKVSGAYTAAVIDADPDAPTPWLASVFVPGPSLGAVVKAVGVLPEEVVRRLAAGLTSALAEIHRAGLVHRDLKPDNVLLAEDGVRVIDLGIARATEGEAEGETGLTRTGWVAGSPAYMSPEQAEGHVLTPASDVFSLGSVLVMALTGRSPFAGTSTLKTLYDVVHTEPDLAGVPAGLRDLVARCLAKDPAARPSPAELRELIGPVTPAGRQWPSAVYGMLAAQRAQIDGLLAGRPVGVDPEPKPAPVPEAEPPAAPAHGTPAPAPKVPPSPAVPPQDTRPGGPRRPRRRRVTALVAAGVLLVAGTGTALYVRDRMNAPIAYTSVPSCREARERLPLDLRSSSADTLSGTADGVQTTCGGGGGTAASPTATVRWDLSLGGSAETDMVTRRRHFQSEAAGQRSASRIGFGTEAYWQSSGGDWTCVLAVREGNLSVRVSLRATPYAKGACETKAKEAARAALKAASH
>NZ_CP018870.1|WP_075970201.1|2253724_2254741_+|hypothetical-protein
MLVLIALGSLAALVWIRYGLLPLRPLNSRLAGPDPLLERTLKAAVAGEWKPAAQLLTDAGKDWDRRDYYVQHLSRSAAWDGAAWLDTWDTARPQDPDVALIRACTQVELAWKARGARRASATSEAQFEAFHQALGDARYDLAHAADLNPEDPTPHSKEIWVALGLGYSPDMTRALWDRVTERAPHLMAAHHGMLQYRSRKWRGSHTEAREFAARAAQDAPPGSLLTVLPLAAWYEEFACFAEERLHPEVFRTPHLIALVDAAIEDAEAADGHPELPWMRHVLGYFLYRQGRYRAAVAQFRHVDGYIGAALPWRYSAFPKLHYRLVRTRTMWGALLRRR
>NZ_CP018870.1|WP_075970200.1|2251390_2253523_-|acyl-CoA-dehydrogenase
MGIGITQEQRELAEAVRGWVARVSPPEEVRKLLDSPPRTGVRPGYWDALTASGLLEPHLEGGTLLDLAVVVEEAARGALPGAYLPSALASVLLDRAGAEPLAGRVGAVALGPGTLTAVATEGGGHLLDGLAPPVLGAGEADLVLLAAEAAHGTRWFAVDAAALDIRTHESADPTRPTAEVRARGAVVPAGRLLELDVVLVRDLACTLFAADACGTAAWALHTAAEYAKVREQFGRPIGRFQGVKHLCADMLVRLEQARALAWDAARAMDEPPDVRSLVAALAAGTALDAAYSCAKDCIQILGGIGFTWEHDAHIHLRRAIVARQLLGPGDGHRLRAVRCAAGGARRGLRVELPARAEEYRAKARAAIEDARGLDPAAARRILAPTGYAAPHLPPPYGLGAGPVEQLVVQQELAAAGVTLCDLGIATWIVPSLLAYGTRAQRDTYVLPTLRGEITWCQLFSEPGAGSDLASLRTRAERRADGSWIVNGQKVWTSSAHSADFGILLARTDPDAPKHKGLGYFVVDMKNTPGIDVRPLKEITGEALFNEVYLDDVELPADALVGTADGGWQVARNTLGNERVHMADRMTFDTGLEALLARAADLDGAHRVRLGALAAEAHALACIGLRTTLQQVSGLEPGAGASVRKLVQTPHQQRTAELALELLGPAGAVREGAGERAVHGMLMSRCLTIAGGTTQVQLNVVAERILGLPRD
>NZ_CP018870.1|WP_045322019.1|2250187_2251375_-|lipid-transfer-protein
MKSYIVGVGMTKFEKPESRDWQYWDMAKEAGSAALADAGVDYGLVQQVPVGYCFQASTAGQRAAYELGLSGVPVYNVNNNCATGSTALMMARQFVEGGLSDCVLALGFEKMKRGALGGGADGGDFSTSPVARHYGIMAAGHGFEMSPPTAQIFGNAAREHMERYGTTPAQLAAVGAKNHRHSADNPNAQFQDVYSVEEVLAAKEIHAPLTKLQCSPTSDGAAAALVVSERFLVAHGLHDKAVEIVAQAMTTDTEESFASGSCVDVVGKPMTAAAARQVYEASGLGIEDVDVVELHDCFSINELLTYEALGMCEDGAAGKLVESGATTYGGRWVVNPSGGLISKGHPLGATGLAQAAELVWQLRGAAGPRQVPGARVGLAHNIGLGGAAVVTLLRR
>NZ_CP018870.1|WP_045322015.1|2249514_2250000_+|hypothetical-protein
MGLFDRLTGTRHPEPGTPARSAAELRAALLALDGPDAPFVLREGTAREGATLVAVWRIPPGPWHPERGRTLLRLDASAREVRTLDERWERLERGERSFDGSGLKYIRGPVDHTSKQWKFGRDSEGRRRLVPETGFSSDAVKAPLREAVLTAGWTWRGTFRL
>NZ_CP018870.1|WP_052680547.1|2249208_2249505_+|hypothetical-protein
MAPGSGSGFASASVPRHLARGAVGFGALIASFALIPFLGPVTLLLAPVGVIALRGCPMCWAIGLAETVSRGRLRRECTNGSCELKAAGKQSGVGEGVS
>NZ_CP018870.1|WP_030030103.1|2248649_2249195_+|RNA-polymerase-sigma-factor
MADRTDWPDEALIVAAQAGDLDSLTALVAGSHPNVRRFAHSLCASREDAEDAAQEALIILYRRIGMLRASGALASWMFRIVRNECLRRARLMPRERPPLPDTAVMSAEDEVLRRLEAGRVAEAIADLPADQRRVLIMRDVQGHSGRAAAEALGLSTAAMKSRLHRARAALQLTLGDTRAHH
>NZ_CP018870.1|WP_052680546.1|2248094_2248457_+|response-regulator-transcription-factor
MDEMPVEHRQARALRVLLDPHNPALALQLGLQPGIEVVRDPMARPEVALVEELATVTALLADDPECRILVLTGSAHPGLREAALAAGAAGLVLRDDRVEDLAEAVRRASTGETVVDPALG
>NZ_CP018870.1|WP_075970199.1|2247034_2247889_-|3-alpha,7-alpha,-12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA-hydratase
MPIDAARALAADPRQGDIGWDHKDIQLYHLGLGAGLPATDPDELRYTLESKLHVLPSFATVAGAGMAMLGGLGQPGIDVNLAHVLHGGHSIELHRPIPVKGRATSSSKVAAVYDKGKAAVIVLRSEVADADGPLWTSDAQIFVRGEGGFGGERGPSAREELPGRAPDRVEERHIREDQALLYRLSGDWNPLHADPEFAKLAGFDQPILHGLCSYGMTLKAVVDTALAGDVSRVRAYRTRFAGIVFPGETLRIRMWQETGRVLVSVTAVERGDAPVLADTVVEHA
>NZ_CP018870.1|WP_045322012.1|2245920_2246997_-|Zn-dependent-alcohol-dehydrogenase
MRAALQSEIGQDKLEVVDDMEAVGFGPGKVKIRIKATGLCHSDLSAMSGVLPQPAPFVPGHEGSGVITDVGDGVTGHAVGDRVLVCWLPPCGHCPSCVRGQGHLCLEAFGNVATPNFRRGDGGVFGFAGTGTFAEEMVVPAACAVPIPDDLPFDIAALIGCGVTTGLGAAVNTAKVEAGSSVAVIGCGGVGISVVQGAKVQGAAQIVAVDPVASRREAALRFGATEAVSPEEFADARNRITAGEGFDYVFEVVGRSATVQKAYEMTRRGGSVVVVGAGALDDNFQINMFSLFFDEKRILPSMYGGGDVLRSYERTIALWRAGRIDLANLITHRVSLAEVNDALDQMRTGVALRTCIEL
>NZ_CP018870.1|WP_075970203.1|2256646_2257495_-|helix-turn-helix-domain-containing-protein
MVGVRDLDPSASPLDYYGSELRRLREDAGLNQAQLGSIVFCTGSLIGQVETTRRVPTRDFSERVDAALGTGGVFSRLVGLVLRHQLPTWFQAYAEMEARAAYISSFQAQLVDGLLQTEAYARSVLAAWSEENLDAKVAARMERQRILDRENPPLSWAVLSEAVLHQEIGGREVMREQLAHLLAMQRRRWVQVQILPFEAGAHAGQMGSFTLLRLEDEHDLVYTEDFVQGHMTANPQALREGSLRYDHLQAAALSLEDSAALIARVLEERYGDQPAPDGREVA
>NZ_CP018870.1|WP_075970204.1|2257605_2259429_+|serine/threonine-protein-kinase
MGELIENRYALEELLGRGGFGEVWRAGDNRVGRQVAVKIGYPQTSEETRRFEREASLAGNLAHPGIATIHDFGRVERHGRDAVFLVMELLGGLTLADVLADGVPPLTDALEWARQIADALGAAHAAGIVHRDVKPANVMVTESGAVKVLDFGIAKAWSGAGARAGAGAATDLTGTGMVIGSFPYMAPERWTGGSNGVPVDGRADLYALGCVLMELLTGDRPFTAREMHELLAQHLTAEPPSPSSLRAGLPTALDTLVRDLLAKDPRQRPSEAAEVSRRLADVARGVGSAPSAAASFPPPPAYAPTVHTAADDAVRRMLERRLTQVLEDSPADVVERLAMLVDDLTDELGAQDALTVRAAYHRAVRVRRQSTTDLERILPRLVRVLGLEHPDTITARATCVGEAAAFGPGDGRRHEEELRELIGQAGRVFGAHGVVTLTARYHLASAMHRGARDRDGQWDARTRERAESERAWLGPLLPDLEWALTADSPVLLDVRRRLAHDAWLVGDFAGAAQLYWRLFPDLAELAEYGDPEVAHRVLRSIGEAGDPVSALAHMDLLLHRLPFFSGGQRLAQEVSDTRAAFRRDVRERRRADGSGGAGGGLSRLFGR
>NZ_CP018870.1|WP_030029855.1|2259539_2260181_+|class-I-SAM-dependent-methyltransferase
MATPKPETLAAFETAKGFMPVREGLALYEAAAAAGALGLPLLEVGTYCGRSTILLADAAREAGVAAITVDHHRGSEEQQPGWEYHDPTVVDPEIGLMDTLPTFRRTLHRAGLEEHVIAIVGRSPQVAATWGGKLGFVFIDGGHTDEHATGDYEGWAPHVAEGGTLVIHDVFPDPADGGQAPYRIYLRALASGAFEEVSVTDSLRVLRRTGPGI
>NZ_CP018870.1|WP_030029857.1|2260285_2261284_+|N-acetylmuramoyl-L-alanine-amidase
MRYDDSPPPPESGSSVNPDRHWFTRRSTLVVGIAALAPACLAGWVLTQALSGAGPDANRPGSAPQPASHSTVPPGQRDAKPGATPSGSPSTEAGTPAAAPVPAAPVKGPLTGKTVVVDPGHNTGNFKHTDEIDQQVDIGTNRKECDTTGTTTNSGYMEAEFTMDVSKRLRAALEAQGAKVVLTHETGARAWGPCITERARIGNEANADAVVSVHADGVSAGNRGFHVILPAKVRSGAADTAKIVEPSRELGERIAGNFARTTGSAPANYLGGGTGLVVRDDLGGLNLSTRPKVFIECGNMRDAKDAAQLTSPEWRQKAAQGIADGIVGFLGG
>NZ_CP018870.1|WP_030029859.1|2261440_2262262_+|membrane-protein
MNIRSLTRGDGVVIGAAALLFIASFLDFYSTTGGDLPSAWDTDAYRLVLPSVFLLGFIAAGLLVAGRFLPESRKVIGMPLSAWGTVLAVSAAWSALWALITCPSTLDLGAGAVIAFLATLALAGVAVFGAKVPALAGSLVPEARPAAPQPYGGQPQPGAGYGYPGGQQPYGSTPQPVPPYGGTPTPAPGPQDSVGGHQGAAAPAPAGDFSPFWFAVPVARPLFAEDGSPTQIAELAPGTWYLAVEQRGATALVAQTQDGRRGVLSDTSGIQRG
>NZ_CP018870.1|WP_075970205.1|2262435_2265033_+|peptidoglycan-recognition-protein
MRGTALAAALGVVATLCLPGAAVAAGPGPDRAGSTASAGTSGPVEGSVRRLALEPKSATEASVSARGTERFGLMGVSWKDAAAEVHGKIEARSRNAATGAWTPWVTLEPLKAGLDGDRPGARGATEPVWVGAADGAEVRVSGGSAALPAGLELDLVDPGTAGRGGAAKSAPAPGARTTAGAAVGAAAPGPESTAPRPDVVSRAQWGADESLNDEGPIYLAGGKIKALFVHHTAATAPYECTDSAAIVRGLHVYHVKTNGWRDLGYNFLVDKCGTLFEGRQGGVDQPVMGAHTYGFNSESTSVAVLGDYTNAGASPAALEGISKMAAYKLGQYDVDMDGSTTLTAGATQKNYAGTSFTAGQAYPFRTVSGHRDGFNTECPGHQLYPQLDTIRKAGPAARLKVVSVNGEPVAPGGTAKTPGQLVVGFSTSTAAQLVSSFELLVDGAPVATVAGDATSVATMLGLGSHRIQIRATAKNGKVSTSLPVTVVADVSDVKYVPVLPKRLMDTRTGVGVPQAKVGPGGVVPLKVAGVQGVPAYGVTSVVLNVTATNPTEAGHVSVYPNGTVRTSASNLNFTPGQTIPNLVVVPVHDGIIQFYNSAGSVDLIADITGYFLASGEGSTHMNLGPKRVLDTRDGTGGVPTAPVGQGGVLDLDLSAVDGLPTSDGLTAVVLNVTATNPTTSSHVSVFPSGTTRTSASNLNFTAGQTIPNLVVVPVVNGRVSFYNNAGSVDLIADITGYFTTSSAGAKHSNLGPKRLMDTRSGLGAAKAPVGEGGVVTLAVAGVEGVPATGVTAVILNVTATNPTTSSYVSVFPSGTTRTSASNLNFTAGQTIPNLVVVPVVDGKVSFYNNAGSVDLIADITGYFSK
>NZ_CP018870.1|WP_075970206.1|2265155_2266166_+|LLM-class-F420-dependent-oxidoreductase
MRLGLALGYWGRGPSSDHLDLATEAERLGYDSVWTAEAWGSDAFTPLTWIAAHTSRIRLGTAIAQMAARTPTATAMHALTLDHLSGGRMMLGLGLSGPQVVEGWYGRPFPASPLTATREYVDVIRQVLRRESPVTLDGRFHSHPYRGGDGTGIGKPLKPITHPLRADLPLLLGAEGPKNIAQTTRIADGWLPLYWSPTRTDVYQASLADLPDGFMIAPMARAKVCDDVAEGLLPVKAMLGFYIGGMGHAARNFHADLMARMGYEEEARRIQQLFLAGRKEEAVLAVPDAFADEISLTGPRERIAERLDLWRKGPVTDLLVTAPDPHTLRVLAELNT
>NZ_CP018870.1|WP_158879932.1|2266233_2266617_-|hypothetical-protein
MIEYVLLAGGVAGVGWLVRRKHLARAGAAPVPGIPGMARMPAGQGRWRPGRVYADGGAARWVPARGETVALPGGRATGLRVPSMKEGISINPGSRIVTCSYEGGGSIEIAVMPLDVRELLEALPQAE
>NZ_CP018870.1|WP_045322030.1|2266772_2267411_-|hypothetical-protein
MSVPTTVRFRRALTAVVLSTALLAGATACGSGGGGSPREELSAASMGELAALAAAEPAAAEADELAAATPSPSTSAEKQKFAKTRFVANAGLAAGATYQWIVKPYREGKFKKGAKGRTFALIKAGLAGAFAYNRLKAAAENAKGDPLLSKAMAPLTAGIESLKGLGTKLRKGQAGDADISSFDDVISSVKEAGKSAGATVTDKVPSTSQLGG
>NZ_CP018870.1|WP_075972037.1|2267523_2267826_+|hypothetical-protein
MTSHTRVRTRGSSQAGRAVALVADVLAFVIVLWILLYFLDANQGNELVAFVHDAATWLAGWSYDLFTFSREWVQVVVGYGLAAVVYVLVGHAVAGRLYRR

Crispr_ID: NZ_CP018870_10

• CRISPR_ID: NZ_CP018870_10
• CRISPR_location: 2366521-2366624
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_10

Consensus_repeat	Method
TGCTCTGCCAATTGAGCTACAGGGGA	CRISPRCasFinder

spacers of NZ_CP018870_10

>10.1|2366547|52|NZ_CP018870|CRISPRCasFinder
CTGCGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGC

CRISPR arrays and Neighbor proteins around NZ_CP018870_10

CRISPR arrays

The CRISPR arrays of NZ_CP018870_10

>merge|NZ_CP018870|10|2366521-2366624|CRISPRCasFinder
TGCTCTGCCAATTGAGCTACAGGGGACTGCGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGCTGCTCTGCCAATTGAGCTACAGGGGA

>NZ_CP018870|10|9|2366521-2366624|CRISPRCasFinder
TGCTCTGCCAATTGAGCTACAGGGGA	CTGCGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGC
TGCTCTGCCAATTGAGCTACAGGGGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_030030724.1|2378560_2379886_+|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl|CDD|235098
NZ_CP018870.1|WP_030030459.1|2363173_2363536_+|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380355
NZ_CP018870.1|WP_045320726.1|2356328_2356937_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075972046.1|2360891_2362226_+|acetyl-CoA-carboxylase	unknown	unknown	gnl|CDD|223895
NZ_CP018870.1|WP_030027845.1|2374046_2376122_-|molybdopterin-oxidoreductase-family-protein	unknown	unknown	gnl|CDD|239155
NZ_CP018870.1|WP_045320741.1|2370500_2372423_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP018870.1|WP_075970236.1|2362279_2363125_-|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
NZ_CP018870.1|WP_030030456.1|2366769_2367075_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030037471.1|2357906_2358944_+|rod-shape-determining-protein	unknown	unknown	gnl|CDD|336482
NZ_CP018870.1|WP_075970238.1|2368770_2370504_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP018870.1|WP_045320727.1|2359051_2359492_-|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224439
NZ_CP018870.1|WP_078848757.1|2364989_2366147_+|YbdK-family-carboxylate-amine-ligase	unknown	unknown	gnl|CDD|237408
NZ_CP018870.1|WP_075972047.1|2376189_2376519_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030030458.1|2363556_2364819_-|MFS-transporter	unknown	unknown	gnl|CDD|236700
NZ_CP018870.1|WP_045320743.1|2376701_2377415_-|DUF218-domain-containing-protein	unknown	unknown	gnl|CDD|225500
NZ_CP018870.1|WP_158879730.1|2359562_2360234_+|LysE-family-transporter	unknown	unknown	unknown
NZ_CP018870.1|WP_075970235.1|2356972_2357695_-|lipase	unknown	unknown	gnl|CDD|224001
NZ_CP018870.1|WP_075970239.1|2377801_2378524_+|sirohydrochlorin-chelatase	unknown	unknown	gnl|CDD|239507
NZ_CP018870.1|WP_030030723.1|2379979_2381254_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|170080
NZ_CP018870.1|WP_075970237.1|2367170_2368619_+|sugar-kinase	unknown	unknown	gnl|CDD|198375

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_030030724.1|2378560_2379886_+|deoxyguanosinetriphosphate-triphosphohydrolase	gnl|CDD|235098	PRK03007, PRK03007, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0
NZ_CP018870.1|WP_030030459.1|2363173_2363536_+|cupin-domain-containing-protein	gnl|CDD|380355	cd02226, cupin_YdbB-like, Bacillus subtilis YdbB and related proteins, cupin domain. This family includes bacterial proteins homologous to YdbB, a Bacillus subtilis protein of unknown function. It also includes protein Nmb1881 From Neisseria meningitidis, also of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.15742e-55
NZ_CP018870.1|WP_075972046.1|2360891_2362226_+|acetyl-CoA-carboxylase	gnl|CDD|223895	COG0825, AccA, Acetyl-CoA carboxylase alpha subunit [Lipid metabolism].	2.77887e-48
NZ_CP018870.1|WP_030027845.1|2374046_2376122_-|molybdopterin-oxidoreductase-family-protein	gnl|CDD|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NZ_CP018870.1|WP_045320741.1|2370500_2372423_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP018870.1|WP_075970236.1|2362279_2363125_-|AraC-family-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	5.83441e-16
NZ_CP018870.1|WP_030037471.1|2357906_2358944_+|rod-shape-determining-protein	gnl|CDD|336482	pfam06723, MreB_Mbl, MreB/Mbl protein. This family consists of bacterial MreB and Mbl proteins as well as two related archaeal sequences. MreB is known to be a rod shape-determining protein in bacteria and goes to make up the bacterial cytoskeleton. Genes coding for MreB/Mbl are only found in elongated bacteria, not in coccoid forms. It has been speculated that constituents of the eukaryotic cytoskeleton (tubulin, actin) may have evolved from prokaryotic precursor proteins closely related to today's bacterial proteins FtsZ and MreB/Mbl.	1.62086e-136
NZ_CP018870.1|WP_075970238.1|2368770_2370504_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	9.62966e-163
NZ_CP018870.1|WP_045320727.1|2359051_2359492_-|Lrp/AsnC-family-transcriptional-regulator	gnl|CDD|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.92576e-32
NZ_CP018870.1|WP_078848757.1|2364989_2366147_+|YbdK-family-carboxylate-amine-ligase	gnl|CDD|237408	PRK13517, PRK13517, glutamate--cysteine ligase.	1.10835e-115
NZ_CP018870.1|WP_030030458.1|2363556_2364819_-|MFS-transporter	gnl|CDD|236700	PRK10489, PRK10489, enterobactin transporter EntS.	4.75035e-73
NZ_CP018870.1|WP_045320743.1|2376701_2377415_-|DUF218-domain-containing-protein	gnl|CDD|225500	COG2949, SanA, Uncharacterized membrane protein [Function unknown].	4.73825e-56
NZ_CP018870.1|WP_075970235.1|2356972_2357695_-|lipase	gnl|CDD|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	7.17435e-25
NZ_CP018870.1|WP_075970239.1|2377801_2378524_+|sirohydrochlorin-chelatase	gnl|CDD|239507	cd03414, CbiX_SirB_C, Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase, responsible for the chelation of Co2+ into sirohydrochlorin, an important step in the vitamin B12 biosynthetic pathway. CbiX often contains a C-terminal histidine-rich region that may be important for metal delivery and/or storage, and may also contain an iron-sulfur center. Both CbiX and SirB are found in a wide range of bacteria.	1.13292e-25
NZ_CP018870.1|WP_030030723.1|2379979_2381254_+|FAD-dependent-oxidoreductase	gnl|CDD|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	1.53947e-71
NZ_CP018870.1|WP_075970237.1|2367170_2368619_+|sugar-kinase	gnl|CDD|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	8.41282e-117

Protein sequences

>NZ_CP018870.1|WP_078848757.1|2364989_2366147_+|YbdK-family-carboxylate-amine-ligase
MIEPGNSTTSTGTAQNTVHPTVPLTVGVEEEFLLVDARTLRVVPAAPMVLATAAGMPGEMHPEGTRYQVEISTPVADSAASLRAELVALRRTLGRAARAHGCRLLAAPSPVVAVEGPLHLTDDLPRQREQHRRFGALTDTLVSCGRHVHIGTLDVDTAVAVSNRIRPWLPTLIALAANSPFWGGRDTGHSSWRAMAWSGWPSAGPPPHFTSTAHFRRSVQTLLGSGAALDTKMVYWDLRPSGHWPTLEFRAPDMSAAVDSAVLQAELARALVATALREIGEQRPEPALRDDVLHLARWRAAHDGLEGFGLDPYTGAELPAADLAEALLDLVAPELAAAGDLDHAAKTLAGLLRDGSGAHRQRAAYARRQDLSDVLRLLVDETEDF
>NZ_CP018870.1|WP_030030458.1|2363556_2364819_-|MFS-transporter
MTRTSAPTRPQRRILADLTPLSTSADYRRLWFGGTISWVGQAMTALAISLQVYDITRSSFAVGLVGLFSLVPLIVFGLYGGAIADTVDRRKLGLYSSLGAAALSVALAAAALVGYHRVWFLYAVVALQAACGALTGPARSAMIPRLLPAEQLPAANALNSVTMTFGTMVGPALGGLIVAVGGYEWAYLVDAVTFTAALYAMWRLPSMKPDRAEGARGRASVADGLRFLGTRPNIRMTFFTDMAAMVLAQPKALFPAIAVLWYGDTAKTVGLMVAAIAAGALLGGLFSGWQSRIRRHGLAILLAVAAWGLAIAVFGLMRNLWLGLFFLALAGYADTVSMVFRTTMLQAATPDDMRGRLQGVFIVVVAGGPRLGDFFAGTAADLTSPAVAVTCGGLGCVVVVGLLALRWRDFARYDARSPKA
>NZ_CP018870.1|WP_030030459.1|2363173_2363536_+|cupin-domain-containing-protein
MTTQKIDVAGKLAGFTEHWAPRRIARVNDYEVKVAKVRGEFVWHTHEDTDELFLVVSGTLTIRLREGDVILGPGEMYVVPRGTEHCPAADEEAHILLFEPVGTVNTGGVGGERTREPVDA
>NZ_CP018870.1|WP_075970236.1|2362279_2363125_-|AraC-family-transcriptional-regulator
MAAIPPPRSTVYAWRPPVPGIAEVFHARFTEHAYPAHVHDTWALMIVDGGRVDFALDRERHGAGVSDAVVLLPPGVVHDGRTVTEAGFRKRVLYLDTSVLPERLTGAAVDAPLLVDAALRERVHGLHLALGQRGRDPLEAQSRLAFVQERLRGWLAGRGEPPAGAAGAAGAGTGGRRLAVRLRELLDARLVEGITLEEASARLGHVHPTHLIRSFRTAYGLPPHAYLTGRRVAVARGLLLAGARPAHAAVEAGFYDQAHLARHFARHVGTSPARFARSRGV
>NZ_CP018870.1|WP_075972046.1|2360891_2362226_+|acetyl-CoA-carboxylase
MAAVSDTGSFTELPAPLGESPADGPLAWAGYDASRARATERTGEHESVVTGTARIGGREAVLVSFEFGFLGGSLGRRTGDRLEAAYTHAREHRLPLVSLIATGGSRMQEGMLALGQLQRVARQSVLTRAAGLPQLAVLRDPTTGGGWATLGAGADVVLALPGAQVGFAGSRVRPADADPAAYTAEGQYAAGHVDAVVPAAQLPGTLAGWLRVLAAPRSGEPVEPPAALAGVRPPATGWDAVRQARDPGRPRAEAYLDAYFELRLHLSGDRAGGTDPGMLCGFGLREGRAVAYAAQCGTATRPAGYRTATRVVRLADRLGIPVLTLVDTPGAANDAAAEHAGAGAAIADTFAALAAATVPVTTLLIGEGGSGGALALAAPGNTWVTPDSYFSVIAPELAAAILKRPPSAAPATADQLRIRPQDLVALGVARGIVTPAGPDGTAGA
>NZ_CP018870.1|WP_158879730.1|2359562_2360234_+|LysE-family-transporter
MSELMTPALAGAAAGLGVAMPMGAMSVLLLQEAIRHRRTAMAAAAGVAVVDLGYAALATAVGPWVASHISPVEAWVRLASAVILLAIAAHGLAGARRGAPAPPPPGQEGPGAAAGAGGGTRTATDVRPARAFARFVALTAINPTTALYFAALTTAQGAVLGSGPAGAAFLVGVGLASLLWQQSLVALGSLAGARISPTARLWTFRLGYGLVAAYALKIAFPLP
>NZ_CP018870.1|WP_045320727.1|2359051_2359492_-|Lrp/AsnC-family-transcriptional-regulator
MDRLDREILGILQQDARISYRDLGVRVGLSANATADRVRRMRREGVIRGFTVVVDPAADTAGGLVVFIDVTLRQDTTNEEFERQVDKLPGITEVVHVTGAHDYLVRARAADPAALDGLLRRLKREAGVAQSNTRIALRAANRPDRL
>NZ_CP018870.1|WP_030037471.1|2357906_2358944_+|rod-shape-determining-protein
MTVSLEQLRRCHVAVDLGAARTRVYVKGAGLVVDEPSVAAVNTRTGALIAVGTFAERMTGRTPDYIRVVRPVSGGTVVDIEMAQRMLRHLLGEKLRRALRRKPRLRAAACTPHDADPLAQRAAVETLVGLGARRVELVDTLIAAAVGCGLPVEQPTATMIMVCGAAATQVAVLSLGSIVTAQRIPVGGEAIDHAVVQHLRHAHELMLPSQAVRPLQLALHGNGLTSGGPASTLIHGRDVATGLARSVHVDTAAVRDAIHTPLTAVLDGIGKVLRDCPPDLVADLTDRGIMMVGGSALLPGLDQMLRDATGMPVAIAERPDVCAVMGLGAMLEGKIAPMVLNPLAG
>NZ_CP018870.1|WP_075970235.1|2356972_2357695_-|lipase
MLTARQGLVALLTLCLALSLAITAPAAARAAGPGPAPASDPVSPRTPVVFVHGYNADPGVWGSLRADLRADGYADAELHSFGYDTHRSVNEVLAGRLAAYVEEVRRETGAAKVDIVSHSFGSLVSRWYVKFGGGAAAVDHWVSLAGPNRGTSTAWACALWDQACRDMTPGSYVVRNLGDGDPTPGAVKYATFWSGCDEVVNPDDSVPLTGAANAAVGCLAHNDLLGDDGTSAGVRAFLTS
>NZ_CP018870.1|WP_045320726.1|2356328_2356937_+|hypothetical-protein
MRPHPDPENVRILCGIVSSVTTFGPAAFQLVLLRRMADFQPGLADEARRRLGASLADQREANKRWQAMVRSPRARGALARYRSVLGPPESAEHRTIGDLECEALLWPLPLWPDLRFEVLAAADGAVWNEWLVRAPGARGPVLDSPADLLPWSATVDEVARAFAPVRPMEGTAPTRWRLAFTTQGRPCVAEFTYGLLQRVAWP
>NZ_CP018870.1|WP_030030456.1|2366769_2367075_+|hypothetical-protein
MRYKVTFVVGLALGYVLGTRAGRERYEKLKKSARQVAQNPAVRNAAETAGHTGREYAGKAFAVVSEKVGDAVPGSLADRVRALRGHSNGQAADDDWGTSNT
>NZ_CP018870.1|WP_075970237.1|2367170_2368619_+|sugar-kinase
MGIVAGLDSSSAFTRIVVCDTDTGAVLRQGYAPHPQPAGEPDGASPHETDPQAWLLSLGEAAGGGILEGVQAIGVSAQQHGLLPLDPQGALVRPALVGNDKRGQAAAADLTEALGGRHAWAEAVGSVPHSAQPVAKLAWLARTEPEAARRVAVLMSPHDWLVWQLLGRPARRTTDRGGASGTGYWSAAAGAWRPDLVELALGHRALLPEVLGPADAAGTTPEGLLISAGTGETMAAALGLGLGPGDAVVSLGASGSVMALHHEALSEPGGLITSLADATGMHLPVVNTSNAVRALRGTAELLGTDLEGLSALALKSTPGAHGLVLLPYLEGERTPSLPHAAGTLSGLRRDSMKPEHLARAAFEGMLCGLVDALDVLRSRGVEIRRVFLLGAAAELPAVQVAAPGLFGTQIVVPAPADYAALGAARQAAWALGVAQGTLAPHTPPHWPAPAAQVFEPGEEFAAWQGVRQQYVATREQIHPGAF
>NZ_CP018870.1|WP_075970238.1|2368770_2370504_+|ABC-transporter-ATP-binding-protein
MLIRLLRTHLGPYRKPIAALVLLQLLQTSASLYLPTLNADIIDKGVVNGDTGYILRFGALMLGVSLVQLVCNVGAVYYGARTAAAVGRDIRGAVFDRVQSFSARELGQFGAPSLITRTTNDVQQVQMLVLMTFTLMVSAPIMCVGGIAMALSLDVRLSGVLLAVVPVLGISVGAIVHRTRPLFRQLQDRLDTVNRVLREQITGNRVIRAFVRDDYEKERFREANADLTGVSLASGRLLALMFPTVIVVVNISSVAVIWFGAMRVDSGGMEVGQLTAFLAYLMQIVMSVMMATFMFMMVPRAEVCAERIQEVLDTESSVVPPAEPVRELTRRGLLELRGADFGYPGAESPVLRGVDLVARPGETTAVIGSTGSGKSTLLGLVPRLFDATGGEVLVDGEDVRRLDPELLARTVGMVPQKPYLFSGTIASNLRYGRPDAGDEELWHALEVAQAKEFVSALEGGLEAPVTQGGTNVSGGQRQRLAIARTLVQRPEIYLFDDSFSALDYATDAALRAALARETEDATVVIVAQRVATIRDADRIIVLDEGQVVGEGRHHELMAGNETYREIVLSQLTEAEAA
>NZ_CP018870.1|WP_045320741.1|2370500_2372423_+|ABC-transporter-ATP-binding-protein
MSGPGGRMMMGPAQRSLDFRGSGRRLLAQLAQDRAKLWGMVLAVVGSVACAVVGPKILGEATDLVFAGIVGREMPAGVTKQQALEAMRARGDEGMADMLSGTDFTPGQGIDFGAVGVVAIWALVVFTLAGLLMLVATRLSNHVMNGTLYRMREELQAKLSRLPLSYFDQQKRGEVLSRATNDIDNIGQTLQQTMGQLLNSLLTIVGVLAMMFWISPLLALVAVGTVPVSVYVAAKIGKKSQPQFVEQWKTTGTLNAHIEEMYSGHNLVKVFGRQKESAAVFAEQNEALYRASFKAQLVSGIMQPVMFFISNINYVLIAVVGGLRVASGSLSIGDVQAFIQYSRQFSMPLTQVASMANLVQSGVASAERVYELLDAPEQERDADVPERPRELRGQVTFDKVAFRYEPDRPLIENLSLSVEPGHTVAIVGPTGAGKTTLVNLLMRFYEVTGGEIALDGVDIAKMTREELRGGIGMVLQDTWLFGGTIAENIAYGASREVTRAEIEEAARAAHADRFIRTLPDGYDTVLDDEGSGVSAGEKQLITIARAFLSDPVILVLDEATSSVDTRTEVLIQKAMARLAHGRTSFVIAHRLSTIRDADVILVMESGSIVEQGTHEELLASGGAYARLYAAQFAQAVAEVD
>NZ_CP018870.1|WP_030027845.1|2374046_2376122_-|molybdopterin-oxidoreductase-family-protein
MSTSATATATHCPYCALQCGMNLRPEPGGAGVTVEERADFPVNRGALCGKGRTAPAVLSSRVRLTEPLVRTHAGRLEPATWEEALDAVAAGLTRTSREHGPDAVGVFGGGGLTNEKAYALGKFARVALRTSQIDYNGRFCMSSAAAAHQKAFGLDRGLPFPLEDIPRTGCVILVGSNLAETMPPALRYLTELKANGGTLIVIDPRRTRTAEQADLHLAPRPGTDLALALGLLHLVVADGRTDEEFIAARTTGWEEARAAAMAHWPELVERITGVPVPALREAVSLFCAPESAMVLTARGPEQQSKGTDTVGAWINLCLATGRAGRPLSGYGCLTGQGNGQGGREHGQKADQLPGYRKLTDPAARAHVAEVWGVDPDSLPGPGRSAYELLDALGTDVKSLLLMGSNPVVSAPRAAHIEDRIRSLDFLAVADVVLSETAALADVVLPVTQWAEETGTTTNLEGRVLLRRRALTPPPGVRSDLDVLHGLAARLGVEKGFPTAPEEVFDELRRASAGGPADYSGITYDRIESEQGVFWPCPEGSAGTQRLFLDRFATDDGRARFVPVAHRDAAEVPDAEYPLLLTTGRVVAQYQSGAQTRRVDELNEAAPGPFVELHPRLAARIGAVDGSPLAVTSRRGRAVAPARITDAIRADTVFMPFHWPGEGRANTLTNPALDPTSRMPEFKVCAVRVEPA
>NZ_CP018870.1|WP_075972047.1|2376189_2376519_-|hypothetical-protein
MRDVLPGLSAELVRLLQEEGEGDLAICAHDLRVLADCGCGDDFCQSFHTASHPPGTPYGPGHRNVALLPARGDLILDVVDGRIMFVEVLGRPELRPALDAALTGGAGPR
>NZ_CP018870.1|WP_045320743.1|2376701_2377415_-|DUF218-domain-containing-protein
MRAAVAVRTVGYRAGWPRRLRGVRGRRRAVRAVMAGCVLALLPSAWTHASAADRLRTTADAPAADVAVVFGAGLWRGRPTPYLADRLDAAAELYRTGKVKVVLVTGDNSRREYDEPDAMRTYLTGKGVPDGRIVSDYAGFDTWDSCVRAKEIFGVDRAVLVTQGFHIRRAVALCQAAGLDSYGVGVADVHDATWRYGQAREFLAAGKAAVDAAFKPAPHFLGPKEQGISQALAASAR
>NZ_CP018870.1|WP_075970239.1|2377801_2378524_+|sirohydrochlorin-chelatase
MQQPTLVAVAHGSRDPRALRTALALLERVRELRPRLDVRLGHIELNEPLLDYTLRAASGAAVLVPLLLGRGHHVKRDLPAAAARATHLDTRVAAPLGPHPLLVEALYERLTEAGWTAGTAVVLGAAGSRDPDSAADTRRTASLLSRRLGGVPVVPAYASAAAPDAPGAVRALAARGHRRIAVASYFAAPGRFATQTAAAAPDLAAAPLGDHPALARLLLHRYDEALARPAARPLPELVSA
>NZ_CP018870.1|WP_030030724.1|2378560_2379886_+|deoxyguanosinetriphosphate-triphosphohydrolase
MEGTAHAPADDLYSPYDPADTERFAAEPDKRPGRTAFQRDRARVLHSAALRRLAGKTQVVTPGTRSYDWDASPRTRLTHSLECAQVGRELGAALGCDPDLVEAACLSHDMGHPPFGHNGEEALNEFAKDCGGFEGNAQSLRLLTRLEPKRFVPGPAGGQPVSVGLNLTRACLDAATKYPWARGGHPTDPGSVKFGAYEDDLPVFQWLRRGAPADRKCFEAQVMDWADDVAYSVHDFEDGLHAGHLDPNLLFAEPERAAIWQVAIGRYVPADTSPEELRAALDRLMEQEWWPHGYDGSAVAQARLKDATSQLIGRFCLAAEGATREAYGSGRLTRYGAELVVPREARNECAVLKAVADLYVIQRDEQERIRADQRIVLAELAEALSARAPEGLDPQFRAIFDAAADDRARKRAVVDQIACLTDASARSLHARLTRRTRRAEG
>NZ_CP018870.1|WP_030030723.1|2379979_2381254_+|FAD-dependent-oxidoreductase
MVDAHRTFVIVGAGLAGAKAAETLRSEGFTGRVILIGDERDHPYERPPLSKGYLTGKEERESVFVHEPSWYAASDIELHLGQPAVHLDREAKRVVLGDGTVMHYDKLLLATGAEPRRLDIPGTGLAGVHHLRRLAHAERLRHVLAGLGRDNGHLLIAGAGWIGLEVAAAARGYGAEVTVVEPEATALHAVLGPEIGRLFGDLHADHGVRFHFGARLTEIVGQDGMVLAARTDDGEEHPAHAVLAAIGAAPRTALAETSGLALVDREHGGGIAVDASLCTSDPDVYAVGDVAAAHHPALGTRLRVEHWANALNGGPAAARAMLGQPVAYDRVPYFFSDQYDVGLEYSGYAPPGGYDQVLIRGDAGKREFIAFWLSEGRVLAGMNVNVWDVTEHIQALIRSKAPVDREALADPSVPLASLVPAEGA

Crispr_ID: NZ_CP018870_11

• CRISPR_ID: NZ_CP018870_11
• CRISPR_location: 2982481-2982561
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_11

Consensus_repeat	Method
CGTCCCGGAGGCGAACCGAGCCC	CRISPRCasFinder

spacers of NZ_CP018870_11

>11.1|2982504|35|NZ_CP018870|CRISPRCasFinder
CGAAAGAAGGCGCGAGTGAGCCGGCAAAAGGCGCC

CRISPR arrays and Neighbor proteins around NZ_CP018870_11

CRISPR arrays

The CRISPR arrays of NZ_CP018870_11

>merge|NZ_CP018870|11|2982481-2982561|CRISPRCasFinder
CGCCCCGCAGGCGAACCGAGCCACGAAAGAAGGCGCGAGTGAGCCGGCAAAAGGCGCCCGTCCCGGAGGCGAACCGAGCCC

>NZ_CP018870|11|10|2982481-2982561|CRISPRCasFinder
CGCCCCGCAGGCGAACCGAGCCA	CGAAAGAAGGCGCGAGTGAGCCGGCAAAAGGCGCC
CGTCCCGGAGGCGAACCGAGCCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_030027101.1|2978548_2979217_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP018870.1|WP_045321778.1|2974430_2977175_-|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl|CDD|366019
NZ_CP018870.1|WP_030027103.1|2977568_2978549_+|stearoyl-CoA-9-desaturase	unknown	unknown	gnl|CDD|224316
NZ_CP018870.1|WP_075970430.1|2991491_2992433_-|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase	unknown	unknown	gnl|CDD|235110
NZ_CP018870.1|WP_075970431.1|2992429_2993341_-|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl|CDD|234708
NZ_CP018870.1|WP_030027106.1|2973589_2974354_+|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl|CDD|369990
NZ_CP018870.1|WP_030027100.1|2979284_2979662_-|glyoxalase	unknown	unknown	gnl|CDD|319909
NZ_CP018870.1|WP_030037382.1|2983748_2984441_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP018870.1|WP_030027109.1|2972148_2972736_+|50S-ribosomal-protein-L25/general-stress-protein-Ctc	unknown	unknown	gnl|CDD|235534
NZ_CP018870.1|WP_030027098.1|2980683_2981181_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_CP018870.1|WP_079273444.1|2993416_2994865_-|resuscitation-promoting-factor	unknown	unknown	gnl|CDD|226111
NZ_CP018870.1|WP_030030900.1|2986355_2987990_-|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl|CDD|379140
NZ_CP018870.1|WP_075970427.1|2982643_2983600_-|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl|CDD|187558
NZ_CP018870.1|WP_075970428.1|2984566_2986288_-|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl|CDD|236090
NZ_CP018870.1|WP_030030899.1|2988143_2989946_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|223562
NZ_CP018870.1|WP_075970432.1|2995310_2996192_-|TatD-family-hydrolase	unknown	unknown	gnl|CDD|238635
NZ_CP018870.1|WP_075970429.1|2989974_2991306_-|acyltransferase-family-protein	unknown	unknown	gnl|CDD|376607
NZ_CP018870.1|WP_030027099.1|2979664_2980522_-|trans-aconitate-2-methyltransferase	unknown	unknown	gnl|CDD|184509
NZ_CP018870.1|WP_045321777.1|2981139_2981907_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP018870.1|WP_030027108.1|2972841_2973432_+|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl|CDD|235457

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_030027101.1|2978548_2979217_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.20735e-20
NZ_CP018870.1|WP_045321778.1|2974430_2977175_-|phosphoenolpyruvate-carboxylase	gnl|CDD|366019	pfam00311, PEPcase, Phosphoenolpyruvate carboxylase.	0
NZ_CP018870.1|WP_030027103.1|2977568_2978549_+|stearoyl-CoA-9-desaturase	gnl|CDD|224316	COG1398, OLE1, Fatty-acid desaturase [Lipid metabolism].	9.02167e-68
NZ_CP018870.1|WP_075970430.1|2991491_2992433_-|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase	gnl|CDD|235110	PRK03188, PRK03188, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional.	1.30373e-152
NZ_CP018870.1|WP_075970431.1|2992429_2993341_-|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl|CDD|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	7.47942e-125
NZ_CP018870.1|WP_030027106.1|2973589_2974354_+|LPXTG-cell-wall-anchor-domain-containing-protein	gnl|CDD|369990	pfam08601, PAP1, Transcription factor PAP1. The transcription factor Pap1 regulates antioxidant-gene transcription in response to H2O2. This region is cysteine rich. Alkylation of cysteine residues following treatment with a cysteine alkylating agent can mask the accessibility of the nuclear exporter Crm1, triggering nuclear accumulation and Pap1 dependent transcriptional expression.	2.92028e-06
NZ_CP018870.1|WP_030027100.1|2979284_2979662_-|glyoxalase	gnl|CDD|319909	cd07245, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	6.13168e-31
NZ_CP018870.1|WP_030037382.1|2983748_2984441_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.86175e-33
NZ_CP018870.1|WP_030027109.1|2972148_2972736_+|50S-ribosomal-protein-L25/general-stress-protein-Ctc	gnl|CDD|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	4.82953e-63
NZ_CP018870.1|WP_030027098.1|2980683_2981181_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.88606e-21
NZ_CP018870.1|WP_079273444.1|2993416_2994865_-|resuscitation-promoting-factor	gnl|CDD|226111	COG3583, COG3583, Uncharacterized protein conserved in bacteria [Function unknown].	4.3656e-55
NZ_CP018870.1|WP_030030900.1|2986355_2987990_-|PQQ-binding-like-beta-propeller-repeat-protein	gnl|CDD|379140	pfam13360, PQQ_2, PQQ-like domain. This domain contains several repeats of the PQQ repeat.	9.65766e-08
NZ_CP018870.1|WP_075970427.1|2982643_2983600_-|UDP-glucose-4-epimerase-GalE	gnl|CDD|187558	cd05247, UDP_G4E_1_SDR_e, UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.6954e-167
NZ_CP018870.1|WP_075970428.1|2984566_2986288_-|PQQ-binding-like-beta-propeller-repeat-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.00342e-09
NZ_CP018870.1|WP_030030899.1|2988143_2989946_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl|CDD|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	1.06061e-164
NZ_CP018870.1|WP_075970432.1|2995310_2996192_-|TatD-family-hydrolase	gnl|CDD|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	9.4572e-96
NZ_CP018870.1|WP_075970429.1|2989974_2991306_-|acyltransferase-family-protein	gnl|CDD|376607	pfam01757, Acyl_transf_3, Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.	1.54126e-14
NZ_CP018870.1|WP_030027099.1|2979664_2980522_-|trans-aconitate-2-methyltransferase	gnl|CDD|184509	PRK14103, PRK14103, trans-aconitate 2-methyltransferase; Provisional.	2.60264e-116
NZ_CP018870.1|WP_045321777.1|2981139_2981907_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.82081e-41
NZ_CP018870.1|WP_030027108.1|2972841_2973432_+|aminoacyl-tRNA-hydrolase	gnl|CDD|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	4.93221e-92

Protein sequences

>NZ_CP018870.1|WP_045321777.1|2981139_2981907_-|response-regulator-transcription-factor
MVRIRVLVVDDHRIFAESLAAALAAEPDVDVSAAGSGPAALRCLERAVAEGRRFDVLLVDADLGAAPGAVPGRREPGAGPPPPAADGITLVAGVRAAHPGVRTVVLAERDEPRRAALALQAGASGWVAKDCSLSRLLAVVRGVLREETHLPPALLTGVLRELTAARKHRTDSERLVESLTPREHEVLRCMVAGLGRKDVAARLFLSPHTVRTHMQNVLGKLGVHSTLAAVALARRAGVRPADLAGDVVERSGQLA
>NZ_CP018870.1|WP_030027098.1|2980683_2981181_+|MarR-family-transcriptional-regulator
MEDEVDRLVAAWRRERPDLDVEPLEVLSRVSRLARHLDRARRLAFSEHGLEPWEFDVLTSLRRAGAPYQLSPGQLLTQTLVTSGTMTNRIDRLAKKGLVERLPDPNDRRGVLVRLTPEGRDRADQALAGLLAQERAILAQLSHSQRGDLAGLLRQLTAPFDNIPG
>NZ_CP018870.1|WP_030027099.1|2979664_2980522_-|trans-aconitate-2-methyltransferase
MYSDTARAGTPTSTAPSAPTWDPQQYLRHAGHRTRPFLDLLARIPELPNRPARIADLGCGPGNVTELLATRWPEAAITGFDLSPEMLQRATDQHAGPTAGGGSLDFRRGDIADWLPEEPYDLIVSNAALQWVPGHPGSFGTWINGLRPGGTFAFQIPGNFTAPSHALLAEQCDTPRWRSRLAGHGARYIHLLEPAEYLARFTALGCTADVWETTYHQLLHGPDPVLEWVKGTALRPVLTALGDDREAVDAFLTEYRDRLRAAYPSGPRGTVFPFRRIFAVARREA
>NZ_CP018870.1|WP_030027100.1|2979284_2979662_-|glyoxalase
MLTAVDHVQLAAPPNSEDRLRAYYTDVLGMTEIPKPPVLAARGGCWFAAGPVQLHLGVEDDFRPARKAHPGLRVTGIEEYAHRLEERGAKVVWDENLPGHRRFYSEDPVGNRLEFLEPYEAQPGH
>NZ_CP018870.1|WP_030027101.1|2978548_2979217_+|TetR/AcrR-family-transcriptional-regulator
MGGVAIDGGTSSDKPRRGRRVRMTGAERRQQLLDIGRALFAEKGFEGTSVEEIAAKAGVSKPVVYEHFGGKEGLYAVVVDREMRQLLDGVTGALTAGHPRELLEQAAFALLDYIESYTDGFRILVRDSPVAQSTGTFASLISDIATQVEDILGLEFKARGFDPKLAPLYAQALVGMVALTGQWWLDVRRPKKAEVAAHLVNLAWHGLDGLESKPQLVGRRKS
>NZ_CP018870.1|WP_030027103.1|2977568_2978549_+|stearoyl-CoA-9-desaturase
MTTSPDLKEGASAPSETSVPSATLGGESKRSIEQIALLLFITVPFVALLAAVPLAWGWGVSWLDLGLMVFMYFLACHGITIGFHRYFTHGSFKAKRPLRIVLAVMGSMAVEGPLVRWVADHRKHHKFSDHEGDPHSPWRFGETVPALMKGLWWAHIGWLFDEEQTDQQKYAPDLIKDPAIRRISRDFIFWTIFSLAIPPLVGGLVTMSWWGAFTAFFWGSLVRVALLHHVTWSINSICHAVGKRPFKSRDRSGNVWWLAVLSCGESWHNLHHADPTSARHGVLRGQVDSSARLIRWFEQLGWATDVRWPSAARIDARRRENRPNAA
>NZ_CP018870.1|WP_045321778.1|2974430_2977175_-|phosphoenolpyruvate-carboxylase
MAAQQAPATPAATANAELRADIRRLGDLLGETLVRQEGQDLLDLVERVRALTRTDGEAAAALLGDTDLETAAKLVRAFSTYFHLANITEQVHRGKELRAHRAAEGGLLARTADMLKDADPEHLRETVKNLNVRPVFTAHPTEAARRSVLNKLRRIAALLEEPVTGAGDRRRHDLRLAENIDLVWQTDELRVVRPEPADEARNAIYYLDELHAGAVGDVLEDLAAELRRVGIELPPGTRPLTFGTWIGGDRDGNPNVTPDVTRDVLILQHEHGITDALELVDFLRSLLSNSIRYTGATEELLASLQADLERLPEISPRYKRLNAEEPYRLKATCIRQKLLNTRERLAKGIPHEEGRDYLGTAELITDLTLIQTSLREHRGGLFADGHMDRTIRTLAAFGLQLATMDVREHADAHHHALGQLFDRLGEESWRYADMPRDYRQKLLAKELRSRRPLAPTPAPLDAAGAKTLGVFAAVKDAFEKFGPEVIESYIISMCQGADDVFAAAVLAREAGLVDLHAGWARIGIVPLLETTDELRAADVILDEMLADPSYRRLVSLRGDVQEVMLGYSDSSKFGGITTSQWEIHRAQRRLRDVAHRYGVRLRLFHGRGGTVGRGGGPSHDAILAQPWGTLEGEIKVTEQGEVISDKYLVPSLARENLELTVAATLQASALHTAPRQSDEALSRWDAAMDTVSDAAHAAYRELVEDPDLPAYFFAATPVDQLADLHLGSRPSRRPDSGAGLDGLRAIPWVFGWTQSRQIVPGWYGVGSGLKALREAGHEDALTEMGERWHFFRNFLSNVEMTLAKTDLRIARHYVDTLVPDHLKHVFARIEAEHELTVREVLRITGGEKLLDSHPVLQQTFAVRDAYLDPISYLQVSLLARQRAAAARGEAADPLLARALLLTVNGVAAGLRNTG
>NZ_CP018870.1|WP_030027106.1|2973589_2974354_+|LPXTG-cell-wall-anchor-domain-containing-protein
MLRSRKRWAAVATALLLSASAGPAFAADSYEVPLHQAKDLPIYAAQFKGKPGETCASIPATKDGWHFIAPGSPNEVSFVKLTVKFEPGGEQVITTFGPPNENHAYAASEPGAKLVSAVALVEGTTGGGKKLEWFNLSHTCPSTATTEPTPSQSSTTPAPSTSTSASTSPSSSTSASPSASASTSASPSSSGSTSPSSSPSSPVPSASASGGTPGGDLAKTGSDAPVGLLATLAAALVAAGALLLVRRRRSGAEG
>NZ_CP018870.1|WP_030027108.1|2972841_2973432_+|aminoacyl-tRNA-hydrolase
MSDDAAPWLIVGLGNPGAEYAGNRHNIGFMVVDLLAERIGGKFKAHKARAQVVEGRMGPPGPANRRVVLAKPMSFMNLSGGPVTALRDFYKVPSERIVAVHDELDIDYPTLRLKLGGGDNGHNGLKSMTKSMGADYHRVRCGIGRPPGRMQVADFVLKDFSSTERKELDWFVDRAADAVECLVAEGLERAQSAYNG
>NZ_CP018870.1|WP_030027109.1|2972148_2972736_+|50S-ribosomal-protein-L25/general-stress-protein-Ctc
MSEVKLSATLRDTFGKGSARQARRDALTPGVIYGHGTAPKHVNVEAHGLMMALKTPNVLLSLDIAGGGNELVIPKAVQRHPLKRTISHVDFLIVKKGEKVVVEVPVVTEGDLAAGGNLLETLLTSISVETEATHIPTEITVSIEGLEAGATVHASDLKLPAGTALAVDGETAVLQVVAPQAEEPAADAEAEGAEA
>NZ_CP018870.1|WP_075970427.1|2982643_2983600_-|UDP-glucose-4-epimerase-GalE
MSKYLVTGGAGYVGSVVAAHLLEAGHEVTVLDDLSTGFRVGVPAGATFIEGRIQDAARHFDPSYEAVLHFAASSQVGESVVNPGKYWENNVGGTLALLTAMREAGVRRLVFSSTAATYGEPTEGLLTEASVTAPTNPYGASKLAVDHMIAGECVAHGLAAVSLRYFNVAGAYGQYGERHSPETHLIPLVLQVALGERESISVFGEDYPTPDGTCVRDYIHVADLAEAHLAALRSATAGEHLICNLGNGNGFSVREVIETVRKVTGREIPEVIAPRRAGDPAMLVASARTAHDRLGWTPNRSDLTGIIQDAWNFARARS
>NZ_CP018870.1|WP_030037382.1|2983748_2984441_-|response-regulator-transcription-factor
MGVRVVVVDDHRLLAEALASALKLRGHRVLAAAAPAAGAAELVISRAPEVCLLGTANPAEPGAFEPVVRIKRERPQTAVVVLGPVPSPRGIAAAFAAGACGYVRQDERIEGVERALAKARSGEAAIAPQLLQGAFAELLNPAVQPDDEGSRLLRLLTPREVEVLVRVAEGEDTRLIAAGMAIAPSTARTHVQRVLMKLGVGSRLEAAALAARTGLLDRALPEPPPTSPQT
>NZ_CP018870.1|WP_075970428.1|2984566_2986288_-|PQQ-binding-like-beta-propeller-repeat-protein
MSTPPPPNQPPSGGFGAPQDPAPGGFGAPTPPAGPPSPPAGPPSPPAGPPAAAPQPPAAQPAYGYPQADPGYGYPQQPAPAPYSAPVPPAPPAGTGGDKRTQLTIVGAALLAIVLIVGGGLWYASGDAGGGTTAQGDPSTSPGGDKNQPSTPGSEKVPGNPKSKILYNHPAPAVTDLVSANGSWLTDTTYVKSDVSKVVGYNLVDGAKKWEIPLNGEICGATHHISENKSAVLFRPAQSTPENKYPPCTEVGVIDLEAGKLVWSGNVKSANGGDKPVQFSEITISGKTVAAGGVSGGGAAWNLADGKNLWQPKVDGESCRDTGYAGGEALGAIRKCGRHPNYTLHAQILDPATGAPTASYKLSEGIEYAHIVSTKPFVVGADVGDNAKGGKGVSDLFVVDPKGELKARIPLAAGTFAAKCASTDVEKCSNMVVGNGKIYVPSAEHQGQSSSGRTNELLSFDLETGKQTTDRADAGERYTIYPLRMDGSNIIAYKVPPYDKGGQIVSIDGSTMKETLLMENPADRDLRRIETSFSPEFSSEFRYRNGKLFMAKQNVSKPYSDDPEYLFVSYTAS
>NZ_CP018870.1|WP_030030900.1|2986355_2987990_-|PQQ-binding-like-beta-propeller-repeat-protein
MTEPPQPPNQPPTPSGYGHLPGPPQQGYGYPQGENPYAQQPAPGHQQPYPQQPPTVAAYPAHNLQPPAPGTPGAPGMPPKKKLTLIVAASVAAVLVLGGVGYVAFGGDEDPKQPVAQESGDAKPSASPSVDMGDGSGPGGNQQTDLNAGRKQGEDKVLWLKTTKIDGPGAGVPAKGQWVVGDTVAKTVDKTIKGYAVADGKEKWTITFPAKICGTTRATTDDGKTVVMYADGPSDTANCNQIRMVDLKAGKEGWSKEVAKESAFDMFLDPSLAMTGDVVTVNRLTRATAFKISTGEKLFGSPSEGCVPGAYAAGSGKLIGIATCNDADMTVEIQDADPATGKKTWTYRLPKGWKVSRVYSVDPVVLHLKNASSKENSVVVLGPDGKQRTTLSGEGSFSTECSMSYDDSLQGCATAVADAGTLYLPTKAAIGKANEIVAFDLTTGKAKWRVPAGEGRTLEPVKAANGQLIAYRKAEANTGGEVLSIPADGSTPTALLRHPSGPSAPIESSFYSPQVDYADGRFFISTSRLLAQDKDEKLLMVFGK
>NZ_CP018870.1|WP_030030899.1|2988143_2989946_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MAVNLVNVEAVSKVYGTRTLLDGISLGVSEGDRIGVVGRNGDGKTTLIRMLAKLEEPDSGRVTQSGGLRMGVLTQHDSLDPAATIRHEIIGDMADHEWAGNAKIRDVLTGLFGGLDLPGFNQGLDTVIGPLSGGERRRIALAKLLIADQDLLILDEPTNHLDVEGISWLAAHLQTRRSALVCVTHDRWFLDQVCTRMWDVQRGEVFEYEGGYSDYVFARAERERIAATEETKRQNLMRKELAWLRRGAPARTSKPRYRIEAANELIADVPPPRDKSELMRFANARLGKTVFDLEDVTVQAGPKTLLKHLTWHLGPGDRVGLVGVNGAGKTSLLRALAEAARSQGDAQPAAGKVIVGKTVKLAYLSQEVGELDPSLRVLEAVQRVRDRVDLGKGREMTAGQLCEQFGFTKEKQWTPVGDLSGGERRRLQILRLLMDEPNVLFLDEPTNDLDIETLTQLEDLLDGWPGSMIVISHDRFFIERTTDTVMALLGDASLRMLPRGLDEYLERRQRMIEAAAPAPAPAAAAAKSSSSGDSRAAKKELQKIERQLNKLADREGNLHAQIAEHSTDYDKVAKLDAELRELLSDRDDLEMRWLELAEEA
>NZ_CP018870.1|WP_075970429.1|2989974_2991306_-|acyltransferase-family-protein
MTASARDIAAATPADRDRYVDLLRVASLGTVIAGHWLMAAVSTDGIGNLLALVPALQPLTWALQVMPVFFFVGGFSHALSYRSLARRGEGSVYAAFLRARLRRLLRPTLAFVLVWAVVALAVQLAGHGGGTLTGAALRLVTQPLWFIGIYLAMVAFTPPLLKLHERHGWAAFAALAGAAALVDVLRFALGVPYVEFLNFALVWLAVHQLGFLRADGRIRRPALLAAGGLSGAVLLVACGPYPLSMVGMPGEKVSNMAPPTLALLCHGLWLVGAVQLAARPAGAWLRRPRVWRTVVAANGVAMTAFLWHLTAMLAVYGAQLALGRDLPAPAGAAWWAQVPVRLLAAAALTGLFVALFRRFEAPAPAHPAGPTGSAAGPVAALGITLCLLGVLGVSMTGLGGLLDGHTATLVAVPVTAPAAIAMALGGAFLVERSATVRRVRLRG
>NZ_CP018870.1|WP_075970430.1|2991491_2992433_-|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase
MSTRPETTRVESTRTAPVTVRVPAKVNVQLAVGAARPDGFHGLANVFLAVSLFDEVTATPADALTVTCEGPDADKVPLDRTNLAARAAEILAARHGLAPDVHLHIAKNIPVAGGMAGGSADGAAALLACDTLWGLNTPREELLDICAELGSDVPFSLVGGAALGTGRGEVLTPVPAGSFHWVFAVADGGLSTPAVFREFDRLTAGTEVPEPQASPALLAALASGDPEALAATLANDLQPAALSLRPSLRATLDAGLAAGALAALVSGSGPTTAFLVTDEEAALKAAAALEASGTCRATRVATSPAPGATALPS
>NZ_CP018870.1|WP_075970431.1|2992429_2993341_-|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MSTAEQQPDNSAPSTPDALLGPADVRELAAALGVRPTKQKGQNFVIDANTVRRIVRTAEVRPDDVVVEVGPGLGSLTLALLEAADRVVAVEIDDILAAALPATIEARMPAKQDRFALVHSDAMLVTELPGPPPTALVANLPYNVAVPVLLTMLDRFPSIERTLVMVQAEVADRLAAEPGNKVYGVPSVKANWYAHVKRAGAIGRKVFWPAPNVDSGLVSLVRRIEPIKTSASKEEVFAVVDAAFAQRRKTLRAALAGWAGSAAGAEAALVAAGVSPQARGESLTVEQFAAIAEHKPAPERPAL
>NZ_CP018870.1|WP_079273444.1|2993416_2994865_-|resuscitation-promoting-factor
MPADTGPSSWDTQPAVPVAVTVPAPVPRVDDRPAVRRRRAAVPAARPDTAGRDGERPGPASGPGTGRRRAPAPTPTLADGFAAGRRPRGRTAVEEPPAGTGRRRAEGPVLLGPTPPAAATGTWRRIVPQALVVAFLAGGTTAFVAADKSVRLTVDGVPRELHTFAGDVEDLLAAEGLAIGPHDLVAPAPGEPLDDGEDVVVRYGRPLRLTLDGQQRQVWTTARTVEGALRQFGIRAEGAYLSAPRTAAVPRAGLTLSVRTERSVTFMADGRERTIRTNAATVQEALDQAGITLRGQDTTSVPPTAFPRDGQTVTVLRITGTREVREERIPFETERVEDGDLFAGTMVVERAGRPGARRVTYSLRTVNGVRQKPRAVADEVVREPVTQLVRVGTRPLPSSVSGADGLNWAALARCESGGRPSATDASGTYGGLYQFDVRTWQGLGGSGRPQDAPAAEQTYRAKKLYVQRGASPWPHCGRRLTS
>NZ_CP018870.1|WP_075970432.1|2995310_2996192_-|TatD-family-hydrolase
MSPSSASKDAPPPLPEPLRVAVADSHTHLDMQSGTVEEGLAKAASVGVTTVVQVGCDVKGSRWAAETAAAHDNVHAAVALHPNEAPRIVHGDPDGWSRQGARAGGGDAALDEALAEIEALAALAHVKAVGETGLDHFRTGPEGMAAQERSFRAHIEIAKRQGKALVIHDRDAHAAVLRVLREEGAPERTVFHCYSGDADMARECAAAGYYMSFAGTVTFKNAAPLREALAVAPLELVLVETDAPYLTPAPYRGRPNAPYLIPLTVRAMAAVRGIDEDAMATALAANTARAFDY

Crispr_ID: NZ_CP018870_12

• CRISPR_ID: NZ_CP018870_12
• CRISPR_location: 3238689-3238785
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_12

Consensus_repeat	Method
CCGCCCCACCCAGCCCCGCCGGCG	CRISPRCasFinder

spacers of NZ_CP018870_12

>12.1|3238713|49|NZ_CP018870|CRISPRCasFinder
TTTGAGGCACGGGCCCCGCGGCGGAGCCCCGGCACACACCCGACCACCA

CRISPR arrays and Neighbor proteins around NZ_CP018870_12

CRISPR arrays

The CRISPR arrays of NZ_CP018870_12

>merge|NZ_CP018870|12|3238689-3238785|CRISPRCasFinder
CCGCCCCACCCAGCCCCGCCGGCGTTTGAGGCACGGGCCCCGCGGCGGAGCCCCGGCACACACCCGACCACCACCGCCCCACCCAGCCCCGCCGCCC

>NZ_CP018870|12|11|3238689-3238785|CRISPRCasFinder
CCGCCCCACCCAGCCCCGCCGGCG	TTTGAGGCACGGGCCCCGCGGCGGAGCCCCGGCACACACCCGACCACCA
CCGCCCCACCCAGCCCCGCCGCCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_030031200.1|3232637_3233216_-|DNA-directed-RNA-polymerase-sigma-70-factor	unknown	unknown	gnl|CDD|237125
NZ_CP018870.1|WP_030031615.1|3246085_3246841_+|SIS-domain-containing-protein	unknown	unknown	gnl|CDD|179510
NZ_CP018870.1|WP_030031613.1|3244013_3244889_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|366166
NZ_CP018870.1|WP_075972099.1|3235938_3237264_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380564
NZ_CP018870.1|WP_030031202.1|3234397_3235282_-|formyltetrahydrofolate-deformylase	unknown	unknown	gnl|CDD|235676
NZ_CP018870.1|WP_075970503.1|3246834_3248211_-|PAS-domain-S-box-protein	unknown	unknown	gnl|CDD|238075
NZ_CP018870.1|WP_075970497.1|3227740_3229294_+|AMP-binding-protein	unknown	unknown	gnl|CDD|171961
NZ_CP018870.1|WP_075970496.1|3226332_3227571_-|amidohydrolase	unknown	unknown	gnl|CDD|368185
NZ_CP018870.1|WP_075970502.1|3238948_3240319_-|transcriptional-regulator	unknown	unknown	unknown
NZ_CP018870.1|WP_030031203.1|3235296_3235743_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030031281.1|3240543_3241224_+|bifunctional-DNA-primase/polymerase	unknown	unknown	gnl|CDD|378140
NZ_CP018870.1|WP_075970498.1|3229842_3230310_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030031280.1|3241372_3242215_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224054
NZ_CP018870.1|WP_037661453.1|3248650_3249274_-|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl|CDD|273138
NZ_CP018870.1|WP_075970500.1|3231387_3232641_-|hypothetical-protein	unknown	unknown	gnl|CDD|274422
NZ_CP018870.1|WP_030027765.1|3249513_3250620_+|citrate-synthase-2	unknown	unknown	gnl|CDD|237070
NZ_CP018870.1|WP_030032980.1|3242286_3243909_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030031201.1|3233517_3234036_+|calcium-binding-protein	unknown	unknown	gnl|CDD|227455
NZ_CP018870.1|WP_053613801.1|3230545_3230755_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030031614.1|3245183_3245876_-|metal-dependent-transcriptional-regulator	unknown	unknown	gnl|CDD|224240

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_030031200.1|3232637_3233216_-|DNA-directed-RNA-polymerase-sigma-70-factor	gnl|CDD|237125	PRK12519, PRK12519, RNA polymerase sigma factor; Provisional.	2.49284e-18
NZ_CP018870.1|WP_030031615.1|3246085_3246841_+|SIS-domain-containing-protein	gnl|CDD|179510	PRK02947, PRK02947, sugar isomerase domain-containing protein.	6.72492e-105
NZ_CP018870.1|WP_030027765.1|3249513_3250620_+|citrate-synthase-2	gnl|CDD|237070	PRK12350, PRK12350, citrate synthase 2; Provisional.	0
NZ_CP018870.1|WP_075970500.1|3231387_3232641_-|hypothetical-protein	gnl|CDD|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	0.000113594
NZ_CP018870.1|WP_030031202.1|3234397_3235282_-|formyltetrahydrofolate-deformylase	gnl|CDD|235676	PRK06027, purU, formyltetrahydrofolate deformylase; Reviewed.	0
NZ_CP018870.1|WP_075970503.1|3246834_3248211_-|PAS-domain-S-box-protein	gnl|CDD|238075	cd00130, PAS, PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.	7.00544e-11
NZ_CP018870.1|WP_075970497.1|3227740_3229294_+|AMP-binding-protein	gnl|CDD|171961	PRK13295, PRK13295, cyclohexanecarboxylate-CoA ligase; Reviewed.	1.94919e-123
NZ_CP018870.1|WP_075970496.1|3226332_3227571_-|amidohydrolase	gnl|CDD|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	3.96528e-35
NZ_CP018870.1|WP_030031281.1|3240543_3241224_+|bifunctional-DNA-primase/polymerase	gnl|CDD|378140	pfam09250, Prim-Pol, Bifunctional DNA primase/polymerase, N-terminal. Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities.	6.40093e-24
NZ_CP018870.1|WP_030031280.1|3241372_3242215_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.776e-88
NZ_CP018870.1|WP_037661453.1|3248650_3249274_-|pyridoxamine-5'-phosphate-oxidase	gnl|CDD|273138	TIGR00558, Pyridoxine/pyridoxamine_5'-phosphate_oxidase, pyridoxamine-phosphate oxidase. This model is similar to Pyridox_oxidase from Pfam but is designed to find only true pyridoxamine-phosphate oxidase and to ignore the related protein PhzG involved in phenazine biosynthesis. This protein from E. coli was characterized as a homodimer with two FMN per dimer. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine].	4.46874e-115
NZ_CP018870.1|WP_075972099.1|3235938_3237264_+|ABC-transporter-substrate-binding-protein	gnl|CDD|380564	cd06341, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.	3.08397e-24
NZ_CP018870.1|WP_030031201.1|3233517_3234036_+|calcium-binding-protein	gnl|CDD|227455	COG5126, FRQ1, Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only].	8.34995e-07
NZ_CP018870.1|WP_030031613.1|3244013_3244889_-|alpha/beta-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	4.08838e-25
NZ_CP018870.1|WP_030031614.1|3245183_3245876_-|metal-dependent-transcriptional-regulator	gnl|CDD|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	2.7513e-44

Protein sequences

>NZ_CP018870.1|WP_075972099.1|3235938_3237264_+|ABC-transporter-substrate-binding-protein
MTISRCAASLPRTLVATATGVCLLAGCGALPGGSGGSGGSGGSGGSGRTITVMTFAPEGTQATNMPGMTGMAKAYERWANTRGGLNGHRLRVLTCNEKNTPGGAADCARQAVAENAVAVVGSYSQHGRAFMAPLEAEGIPFVGGYGVSSEEFQSPLSYPVNGGQPVLIAGAGHQLSRACDQVALVRPDTLAGDTLPVMLNAGLRANKMADAADILAAEDSADFKPQAGEAIAHTTGTGTGKEREGKARGCVTAVLGERTETFFDAFRRTEPQRSKPQISSVLGSVSQSLVDRTGGRESPFEGAYVTSWYPVASDPLWEPMRRVVADFAFGDDTVDPDDSGVQTTWIAYTVLGEIMNRFGKEESIDARRIRRSLNEARPVRTAGLTPDLSWRSEDMRAVAGFPRIVNGRVTFQVVRDGRLVAQPGEQPMDMTPTLVQAPRTA
>NZ_CP018870.1|WP_030031203.1|3235296_3235743_-|hypothetical-protein
MGGMPLNDMPWWRWRSNVRSALHMLSDPAFHEDTWLAGAEGYGDVTDAVYRLVEDTWLDSWSAEKYVGTIFRDSQEAALVDLAVLRVLRILHQVGPDAPVSVYLEHHAWPEAVRAAREAHVRLAQADGDDPDVRPTSLEVLKILTRAV
>NZ_CP018870.1|WP_030031202.1|3234397_3235282_-|formyltetrahydrofolate-deformylase
MSDPHNEAQAQQQPQYVLTVSCPDKQGIVHAVSSYLFMTGCNIVDSQQFGDRETGLFFMRVHFEAEPTVTVEKLRASFAAIGESFKMDWEIHRSEERMRIILMVSKFGHCLNDLLFRSRIGALPVEIAAVVSNHTDFAELVASYDVPFVHIPVTKDTKAQAEAQLLELVRAENVELVVLARYMQVLSDTLCQELSGRIINIHHSFLPSFKGAKPYHQAHARGVKLIGATAHYVTADLDEGPIIEQEVERVGHEVTPDQLVAIGRDVECQALARAVKWHSEHRVLLNGSRTVVFA
>NZ_CP018870.1|WP_030031201.1|3233517_3234036_+|calcium-binding-protein
MDSAEYERKIAARFATFDQDGSGFIDREDFSAAAKAVLAEFGTAARSEKGQAVFGGAEAFWQGMAGIADVDGDQRVSREEFITGAAKRLRDNPQRFAEIARPFLRAVIAVADEDGLGATPSAAARVLRVLGTAPEPAEQVALGLDTDGDGRISEDEILAAFASYCGVEAPDA
>NZ_CP018870.1|WP_030031200.1|3232637_3233216_-|DNA-directed-RNA-polymerase-sigma-70-factor
MPKDVPPRWDRRMQQRLARGEAAALGELYDRFASLVHSLAHRVLGDEKAADRITREVFGYIWENPDAYDPKQGSMRSWVARITQGQAVARLRQAELGRGSREELEQKVRTANAAARADYIVTSMPAPLRAALELAYFKRRDYRQAAADLRISEDEARRRLRLGLQLLSTANALPPEDATQPGYGPREYGTPR
>NZ_CP018870.1|WP_075970500.1|3231387_3232641_-|hypothetical-protein
MNGPAQSPDDGYERPGGQARIPGPRGAADDLDPGHAPRPLPLPLPTEPAPPPPSHAVLKSLLGAWALAACSAEETRAVEDHLTECAPCAEEALRLRDAVGLLHPEETLDLKPLLRSRVLEDCLGKRPARIPVPGWASPYDTETARLDALLQDFGDSEWHTPVRLKWFEEERHRSHRTTVAGVIGHLMTVDGLIATALGLDDPLGADAPPGGPTVRTEHFWGASSYPATRQVREPWRQQGHTLVRTVSFAGRGVAELAVDYGSFALPLGDAFLERAFECWVHAWDIADAVDYPYEPPSGPHLHRMIDLAARLLPGALAQRRRAGLAAPARGLVAAGAPGRTLHLEIEGAGGGGWDIALDSPGAKPSAERTVAEIALDGLEFCQLAAGHISPEDAAVGQHGDREAIRDVLFAAASLSRL
>NZ_CP018870.1|WP_053613801.1|3230545_3230755_+|hypothetical-protein
MSDRYEYVPHRLLRHPVRDIASGVEGELMAVINENVSDSGREHWVELAYIRGASGREFTTSVSNVEPAG
>NZ_CP018870.1|WP_075970498.1|3229842_3230310_+|hypothetical-protein
MSADNAAVNFSELVNKNKQTLARLKESPRLLLHRRDGEDLVLTTAAKAEQDQTVVSAASRMLSAMARREPGSMELLLDILPEAFPWVRFLPEPDVHAFAVELVDTMRAADSIGNNASVAQMLTAWQHTAEVHSDPVLLAALNQDHGTDYGPVPHP
>NZ_CP018870.1|WP_075970497.1|3227740_3229294_+|AMP-binding-protein
MTDTATATELSRSRTLWELITRRAALTPDTTALIEAAEDPAADRTLTFGELRDRSERVAAGLYDMGVRPGTVVAWQLPTRIETVLLTVALARLGAVQTPVIPFYRDREVGFALREAKADFFATPGVWRGHDYPAMARRLGARGVFDAYDTLPDGDPDVLPPPPAYGTDVRWIYWTSGTTSDPKGVLHTDRSLIAGGSCLAHALHLTPSDVGSMAFPYAHIAGPDYTVMLLLYGFPAVLFEKFAMPDALDGYRRHGVTVAGGSTAFYSMFLTEQRKAPDVPLIPTLRLLAGGGAPKPPEVYHAVIRELGCQLTHGYGMTEVPMITMGAPDDTPEHLATTEGRPPQGMSIRITTPDGTPLPAETDGEVRLRGEAVCQGYLNRDQSAEVFDHDGYLITGDLGHLTRDGYLVLTGRSKDVIIRKGENISAKEIEDLLHRLPGVADVAVIGLPDQTRGERVCAVVEQPEGAAPLTLPQLTAYLRAEGLATHKLPEQLELLDALPRNEALRKVLKYKLRERYA
>NZ_CP018870.1|WP_075970496.1|3226332_3227571_-|amidohydrolase
MELPRIISVDDHVIEPAHLFDVWLPARYRDRGPKALTAGIGELRYTGGRYVITMDPDGPPTDWWIYEDLKFPYKRNIAAVGFDRDDMTLEGITREEMRQGCWDPKARLADMDLNHVEASLCFPTFPRFCGQTFAEAHDKEVALACVRAYNDWMVEEWCGDSGGRLIPLCIIPLWDIDLAVAEIRRNAARGVRAVTFSEIPTHLGLPSIHSGYWDPFFAACQETGTVVNMHIGSSSQMPAASPDAPPAVQASLSFNNAMASMMDFLFSGVLVKFPTLKLAYSEGQMGWIPYALERADDVWEEHRAWGGVRDLIPEPPSTYYYRQIFCCFFRDKHGIASLDVVGRDNATFETDYPHVDSTFPHTKEVALDHVRGLDEETVYKLMRGNAIRMLGLDLDRNRGRELGRSKSTGAGR
>NZ_CP018870.1|WP_075970502.1|3238948_3240319_-|transcriptional-regulator
MAARPLVARQPNERLQALIQEAGCSNAGLARRVNMCGAEHGLDLRYDKTSVARWLRGQQPRGRAPGIIAEALGRKLGRTVTIDEIGMANGKNLASGVGLQFSPTVIGAIEQVCELWRSDVGRRDFLVGSSVAASALVEPSRDWLITGADTQVARSGGSRVGMPDVEAVLATTDALKDLDHRFGSGHVRPVVVHYLNSVVSGLIGGSYREAVGRALFAAVARLTELAGYMAVDTGQPGLAQRYYIQALRLAQAAGDRAYGGYVLAASMSHLAAELGNPREIAQLARAAQEGTRGQVTPRVEAMYYAAEARGHALLGDGRATGVLSARAVSALERAEPESGDDPVWIRHFDEAYLADELAHCHRDLGQGDAAARQAQEALRALPAGKARRRAIGLLLLASAQVQQREVEQACRTATQAAELLDGLRSNRGAEYLHDFRTRLEPYREEAAVREFAARVA
>NZ_CP018870.1|WP_030031281.1|3240543_3241224_+|bifunctional-DNA-primase/polymerase
MEETMGVTETAPIPKQRGEQLLDHAVRYAEERHWDVFAGTWLEPGDGRELCSCGAADCPAPGAHPAVKDWAAHATGSAVQVRRVWGKHPQASILLPTGRTFDALDVPESAGFLALARLERMQRTLGPVTLTPDHRMLFFVLPGAGAKVADLVRKLGWTPSAIDLAARGEGEYVAAPPTRFGGRGAVQWARRPTPANRWLPDTEELIDALAYACGSEAAAERRRRQG
>NZ_CP018870.1|WP_030031280.1|3241372_3242215_+|ABC-transporter-ATP-binding-protein
MPDRDDATGGTDRTDGARTAPSAVRVEGLWKRFGEQVAVAGIDLELPAGKFIGLVGPNGAGKTTTLSMVTGLLRPDMGRVVVAGHDVWADPAEVKARIGVLPEGLRLFERLSGRELLGYMGRLRGLPGDETDKRATQLLDILDLAGSQHKLVVDYSTGMRKKIGLAAALLHNPEVLFLDEPFEGVDPVSAQTIRGVLERYTASGATVVFSSHVMELVESLCDWVAVMAAGRIRAAGPLADVRGSAPSLQAAFLELVGAHGRDTSGDALDWLGGNSAAVTR
>NZ_CP018870.1|WP_030032980.1|3242286_3243909_+|hypothetical-protein
MAAGRAASAAPLALTPIFVRIKLSLLRNGLKGSSKRKAAYFSTLAFALLVGGFMTLGLGLLRGHAQAGTAVVLLAAILALGWAFMPLFFPTGDETLDPSRLVMLPLRPRPLVTALLASSLVGIGPLFTLCLAVGSVVAVARGAAGAVAAVVAVPLLLLGCVILARAVATANVRLLTSRKGRDLALLSGLVIAVGAQLANFASQSLFQSGGLATLEPVSAVVRWLPPATAVGMVDSASEGAYGRAAAQLVLTLAALAGLLWSWERSLTRLMVTADGSTISASGPVKDRGGAGGGFWSLLPSGRTGASMQRALRYVVRDPKTKSAWVTALAIGLIVPVFNALQGTGSVYLGSFGAGMLGVQMYNQFGQDTSAFWMVAQTISGPRDAYVELRARALALGLVTLPYTVLVTVVTAALLDDWQGFPAAVGVALALLGSMLCTGALASARFPYSIPTEGAFKNVAPGQGGLAWGGILGGMLVSALVCAPVIALAVWLNTAGNRDVSWILLPVGVAWGWLAAWVGLRLAAPTVARKLPEILSAVSKG
>NZ_CP018870.1|WP_030031613.1|3244013_3244889_-|alpha/beta-hydrolase
MVQRIDVTGAEGVRLAAWQFREPVPEADSRPGVLLLHGLMGRASHWAGTAHWLGERRRVVALDQRGHGHSDRPPPGAAPHTTLGREAFVADAEAAVEQLDLAPVTLIGHSMGALTAWQLAARRPDLVAALVICDMRASALGAASQREWEDWFRLWPLPFPTQDAARRWFGADDPRVERPDPGRGAFFAEVMHQSADGWRPLFSRRQMLTARETWVHDAHWEELAQVRCPTLVVRGLDGELGRAEAQEMVRVLPAGRYAEIPDAGHYLHYDQPAAWRAVLEPFLDDIPAPAP
>NZ_CP018870.1|WP_030031614.1|3245183_3245876_-|metal-dependent-transcriptional-regulator
MSGLIDTTEMYLRTILELEEEGVVPMRARIAERLDQSGPTVSQTVARMERDGLVAVATDRHLELTDEGRRLATRVMRKHRLAECLLVDVIGLEWEQVHAEACRWEHVMSEAVERRVLELLRHPTESPYGNPIPGLEELGEKAEAEQFLEDGMISLSELDPGTEGKTVVVRRIGEPIQTDAQLMYTLRRAGVQPGSVVSVTESPGGVLVGSGGEAAELEADIASHVFVAKR
>NZ_CP018870.1|WP_030031615.1|3246085_3246841_+|SIS-domain-containing-protein
MSESKLAGQFFDAAIGLLERVRDEEAPRIAEAGTLIADAVAAGNRLFAFGAGHSSLPAQDVVYRAGGLALMNFLAVPGTAGVDVMPATLGSALERVDGLAGAVLDSSPASDGDVLVIISLSGRNALPVEMAMNARAVGLKVIGVTSVAYATGTRSRHVSGTFLKDHCDIVLDSKIAVGDAELSIDGIDAPFAPASTVVTSAIMQAVMATAAGELAARGMEPPLLRSGNVDGGHEWNGRVMQEYGDRIFFRH
>NZ_CP018870.1|WP_075970503.1|3246834_3248211_-|PAS-domain-S-box-protein
MSASGRDETTDDLLAALLDGMDAALCAFDSDGVITHWNREAERILGWSAAEAVGRKGFEGWAVRAADAQDVQDRLMSAQQVPGRQVHEFALLTKDGGRVLVRTQSAGVPGADGSPAGVYCAFSEVHAQIDLERSIALSEALMEDASWGVVLVDVDLRPAVVNVHAARAFGTGRTALLGRPLGELLAQGVEELEGALQHVLAEGAPPAPVEMWVSVRTAEGVRRRCWRCGFLRLASPLAEEPVPLGVGWLLQDVTEARQEQLDTAQARFRSHQLHRAGRAAAECEDPAEAAGVRLDFALAGFAEHALLDVLAPAADTERRRLVRCAASPPALPGPGSIPVRYAAGHPALQALDRIGSVRTSGPRGEADAEWARARQWPEGAAHGLCAVLRSRGRTLGVLTFLRGPSRPAFERADAAYAEEVAARVAADLDLAAAGAGAAGAGAAGHGPGPGAGAGAAPQ
>NZ_CP018870.1|WP_037661453.1|3248650_3249274_-|pyridoxamine-5'-phosphate-oxidase
MRKQYRSEIVHEVSLAEDPMEQFARWFQQAADSHLFEPNAMVVSTATPDGRPSSRTVLLKQFDSRGFVFFTNYASRKGRELAANPQVALLFPWHPIARQVIVTGTASRIGRDETAAYFRSRPHGSQLGAWASEQSSVIGSREELDRRYAELTERYPEGEQVPVPPEWGGLRVVPQEVEFWQGHENRLHDRLHYVLEGGKWRLERLCP
>NZ_CP018870.1|WP_030027765.1|3249513_3250620_+|citrate-synthase-2
MSDFVPGLEGVVAFETEIAEPDKEGGSLRYRGVDIEDLVGHVSFGNVWGLLVDGAFNPGLPAAEPFPIPVHSGDIRVDVQSALAMLAPVWGLKPLLDIDVQTARDDLARAAVMALSYVAQSARGQGLPMVPQREIDKAESVVERFMIRWRGEPDPKHVKAVDAYWTSAAEHGMNASTFTARVIASTGADVAAALSGAVGAMSGPLHGGAPSRVLGMIEEIERTGDAVAYVKKALDKGERLMGFGHRVYRAEDPRARVLRRTAKELDAPRYEVAAALEKAALEELHARRPDRVLATNVEFWAAIMLDFAEVPAHMFTSMFSCARTAGWSAHILEQKRTGRLVRPSARYTGPGRRNPQEIEGYADIADTA

Crispr_ID: NZ_CP018870_13

• CRISPR_ID: NZ_CP018870_13
• CRISPR_location: 4195370-4195457
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_13

Consensus_repeat	Method
AGGAGCGCGTAGCGATCTGGGGCG	CRISPRCasFinder

spacers of NZ_CP018870_13

>13.1|4195394|40|NZ_CP018870|CRISPRCasFinder
GCCTATGTCCAGCCACAGGGGTCCGCTGACGCCGTCCTTC

CRISPR arrays and Neighbor proteins around NZ_CP018870_13

CRISPR arrays

The CRISPR arrays of NZ_CP018870_13

>merge|NZ_CP018870|13|4195370-4195457|CRISPRCasFinder
AGGAGCGCGTAGCGATCTGGGGCGGCCTATGTCCAGCCACAGGGGTCCGCTGACGCCGTCCTTCAGGAGCGCGTAGCGATTTGGGGCG

>NZ_CP018870|13|12|4195370-4195457|CRISPRCasFinder
AGGAGCGCGTAGCGATCTGGGGCG	GCCTATGTCCAGCCACAGGGGTCCGCTGACGCCGTCCTTC
AGGAGCGCGTAGCGATTTGGGGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_075970801.1|4192020_4192812_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|367243
NZ_CP018870.1|WP_030027026.1|4188097_4188688_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_045321423.1|4203631_4204399_-|DUF3558-family-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030028038.1|4197129_4197927_-|VOC-family-protein	unknown	unknown	gnl|CDD|319911
NZ_CP018870.1|WP_037918680.1|4188731_4189031_+|hypothetical-protein	unknown	unknown	gnl|CDD|375857
NZ_CP018870.1|WP_075970807.1|4205608_4206802_+|RtcB-family-protein	unknown	unknown	gnl|CDD|376465
NZ_CP018870.1|WP_030851864.1|4189043_4189700_+|hypothetical-protein	unknown	unknown	gnl|CDD|376019
NZ_CP018870.1|WP_075970805.1|4196007_4196832_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|197775
NZ_CP018870.1|WP_075970804.1|4195765_4196011_-|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NZ_CP018870.1|WP_030027023.1|4189866_4190139_+|DUF1876-domain-containing-protein	unknown	unknown	gnl|CDD|378103
NZ_CP018870.1|WP_107484917.1|4204512_4205376_-|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NZ_CP018870.1|WP_075970799.1|4186281_4188081_+|hypothetical-protein	unknown	unknown	gnl|CDD|375857
NZ_CP018870.1|WP_045324392.1|4190186_4190945_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|272861
NZ_CP018870.1|WP_045321424.1|4202179_4203499_-|DUF2637-domain-containing-protein	unknown	unknown	gnl|CDD|378511
NZ_CP018870.1|WP_075970802.1|4193347_4194109_-|hypothetical-protein	unknown	unknown	gnl|CDD|372627
NZ_CP018870.1|WP_075970803.1|4194089_4195283_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030028041.1|4198340_4200110_-|arginine--tRNA-ligase	unknown	unknown	gnl|CDD|215160
NZ_CP018870.1|WP_075970800.1|4190941_4191919_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|130256
NZ_CP018870.1|WP_107069568.1|4198102_4198291_+|hypothetical-protein	unknown	unknown	gnl|CDD|350322
NZ_CP018870.1|WP_075970806.1|4200352_4202092_+|lysine--tRNA-ligase	unknown	unknown	gnl|CDD|234829

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_075970801.1|4192020_4192812_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|367243	pfam02909, TetR_C, Tetracyclin repressor, C-terminal all-alpha domain.	1.77361e-15
NZ_CP018870.1|WP_045321424.1|4202179_4203499_-|DUF2637-domain-containing-protein	gnl|CDD|378511	pfam10935, DUF2637, Protein of unknown function (DUF2637). This family of proteins has no known function.	2.03992e-36
NZ_CP018870.1|WP_107484917.1|4204512_4205376_-|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	6.23279e-08
NZ_CP018870.1|WP_030028038.1|4197129_4197927_-|VOC-family-protein	gnl|CDD|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	2.81194e-31
NZ_CP018870.1|WP_037918680.1|4188731_4189031_+|hypothetical-protein	gnl|CDD|375857	pfam18431, RNAse_A_bac, Bacterial CdiA-CT RNAse A domain. Contact-dependent growth inhibition (CDI) is an important mechanism of inter-bacterial competition found in many Gram-negative pathogens. CDI+ cells express cell-surface CdiA proteins that bind neighboring bacteria and deliver C-terminal toxin domains (CdiA-CT) to inhibit target-cell growth. Structure analysis of CdiA-CT shows that it adopts the same fold (with two beta-sheets forming an overall kidney shape) as angiogenin and other RNase A paralogs, but the toxin does not share sequence similarity with these nucleases and lacks the characteristic disulfide bonds of the superfamily. Furthermore, structural comparison analysis identified human angiogenin, Rana pipiens protein P-30 (onconase) and mouse pancreatic ribonuclease (RNase 1) as the closest structural homologs of CdiA-CT.	1.31643e-13
NZ_CP018870.1|WP_030851864.1|4189043_4189700_+|hypothetical-protein	gnl|CDD|376019	pfam18593, CdiI_2, CdiI immunity protein. Contact-dependent growth inhibition (CDI) is an important mechanism of inter-bacterial competition found in many Gram-negative pathogens. CDI+ cells express cell-surface CdiA proteins that bind neighboring bacteria and deliver C-terminal toxin domains (CdiA-CT) to inhibit target-cell growth. CDI+ bacteria also produce CdiI immunity proteins, which specifically neutralize cognate CdiA-CT toxins to prevent self-inhibition. Structure analysis of CdiI immunity protein from Yersinia kristensenii shows that it is composed of eight alpha-helices packed together to form a nearly spherical structure with weak structural homology to a putative TetR family transcriptional repressor. The CdiI protein fits into the curved cavity of the CdiA-CTYkris toxin domain where it most likely neutralizes toxin activity by blocking access to RNA substrates. This domain is mostly found in gammaproteobacteria.	8.48257e-26
NZ_CP018870.1|WP_075970805.1|4196007_4196832_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	5.26189e-05
NZ_CP018870.1|WP_075970804.1|4195765_4196011_-|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	3.31191e-18
NZ_CP018870.1|WP_030027023.1|4189866_4190139_+|DUF1876-domain-containing-protein	gnl|CDD|378103	pfam08962, DUF1876, Domain of unknown function (DUF1876). This domain is found in a set of hypothetical bacterial proteins.	3.66672e-30
NZ_CP018870.1|WP_075970799.1|4186281_4188081_+|hypothetical-protein	gnl|CDD|375857	pfam18431, RNAse_A_bac, Bacterial CdiA-CT RNAse A domain. Contact-dependent growth inhibition (CDI) is an important mechanism of inter-bacterial competition found in many Gram-negative pathogens. CDI+ cells express cell-surface CdiA proteins that bind neighboring bacteria and deliver C-terminal toxin domains (CdiA-CT) to inhibit target-cell growth. Structure analysis of CdiA-CT shows that it adopts the same fold (with two beta-sheets forming an overall kidney shape) as angiogenin and other RNase A paralogs, but the toxin does not share sequence similarity with these nucleases and lacks the characteristic disulfide bonds of the superfamily. Furthermore, structural comparison analysis identified human angiogenin, Rana pipiens protein P-30 (onconase) and mouse pancreatic ribonuclease (RNase 1) as the closest structural homologs of CdiA-CT.	1.4936e-20
NZ_CP018870.1|WP_045324392.1|4190186_4190945_-|ABC-transporter-permease	gnl|CDD|272861	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family. The seed members for this model are a paralogous family of Mycobacterium tuberculosis. Nearly all proteins scoring above the noise cutoff are from high-GC Gram-positive organisms. The members of this paralogous family of efflux proteins are all found in operons with ATP-binding chain partners. They are related to a putative daunorubicin resistance efflux protein of Streptomyces peucetius. This model represents a branch of a larger superfamily that also includes NodJ, a part of the NodIJ pair of nodulation-triggering signal efflux proteins. The members of this branch may all act in antibiotic resistance.	1.35875e-13
NZ_CP018870.1|WP_075970802.1|4193347_4194109_-|hypothetical-protein	gnl|CDD|372627	pfam13532, 2OG-FeII_Oxy_2, 2OG-Fe(II) oxygenase superfamily.	0.000143027
NZ_CP018870.1|WP_075970807.1|4205608_4206802_+|RtcB-family-protein	gnl|CDD|376465	pfam01139, RtcB, tRNA-splicing ligase RtcB. This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyze the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage.	7.67502e-173
NZ_CP018870.1|WP_030028041.1|4198340_4200110_-|arginine--tRNA-ligase	gnl|CDD|215160	PLN02286, PLN02286, arginine-tRNA ligase.	0
NZ_CP018870.1|WP_075970800.1|4190941_4191919_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	7.39441e-101
NZ_CP018870.1|WP_107069568.1|4198102_4198291_+|hypothetical-protein	gnl|CDD|350322	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins. This subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC3 and VapC21 toxins. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.46488e-20
NZ_CP018870.1|WP_075970806.1|4200352_4202092_+|lysine--tRNA-ligase	gnl|CDD|234829	PRK00750, lysK, lysyl-tRNA synthetase; Reviewed.	0

Protein sequences

>NZ_CP018870.1|WP_075970803.1|4194089_4195283_-|hypothetical-protein
MYPTEARIDDASNILVAPSTLWDHDLIRDFFGTTITPAEFASADIADRTVYMCGDVSGVDGGRLRSAARVFVIRELSRGYGPDQPWTVVEGGRVPVRVHGVGVYYRRFFDLDADHFGRIQAEHAFQSLTESTKPGTARRSGIYLTPVTQDGDALHFRLLRCSTNLSGPTEGFRATDTEIVDALNREAASAFRNHAPLNHVLAQVYHNTLATAERKQSKAKISAHADKTKDMPDNGIMAFCTFYDGLDKLQPMADDVFDYGLKRTSGLTRLHFRLKDDAGALPSSFTLTLYPGSVFFMPLSTNRLYTHEIRPSTLNAEALPTRLGYVVRCSSTEAVHKDGRTFVKKADDLVELGPPTPEGMDELRRLYAEENRTASFIDYGDKFLFSMNSGDYVAPRA
>NZ_CP018870.1|WP_075970802.1|4193347_4194109_-|hypothetical-protein
MLPPAPRITDEVSSYALSFERNLFAELSESAPWEDVGKGRRGGTLTRADEHGTPLVRTTTRYSNPTQRFSPVHEWLAQQIQERAALPVGFNNALIESYTNAYRTMGSHSDQALDLADDSFIAVFSCYRHPEAGPPRKLVFESKESDATFDLPLSHHSVVVFSVASNRRLKHKIVLDAPAAENEWLGVTFRTSKTLVRFHDGHAHLPQGGRLTLADEDQSREFYRLRRRENHETDFLYPSLTYTVSESDLLPPV
>NZ_CP018870.1|WP_075970801.1|4192020_4192812_+|TetR/AcrR-family-transcriptional-regulator
MAEEDDEGAENGGTGLPASLEMAWGLRERPGKGPRPTLTLPRIVETAVTLAAREGIDAVSMGRVAKELGVSTMSLYRYVTAKEELYILMSDAGVGAPPALPPEAAGWGWRELLTQWAYAQRAVLMANPWILRIPITGAPVSPNQLAWMERGLAALAGTGMSEGEKISTIILIGGLVRNEATMAADMMDAIIKSGVSPDQVLGQYVRTLRLMTAPDTHPAVTRLLESDAFTGSDEPDFQFGFGLGRILDGLAALVAGREGAGEG
>NZ_CP018870.1|WP_075970800.1|4190941_4191919_-|ATP-binding-cassette-domain-containing-protein
MTTHASGRVTGAPGPRATGADTLGIQATGLTKSYGDVRVLDGIDLAVPRGSVLALLGPNGAGKTTTVRILATLTAPDAGTARVAGHDTATAQARVRERISLTGQFAAVDELQTGAETLRMMGRLSGLTPRAARVRADELLARFGLADAAARTAKTYSGGMRRRLDLAASLVSRPEVIFLDEPTTGLDPRSRQDLWELVRELRADGTTVLLTTQYLEEADRLADRVVVLADGRIAAEGTPAELKARVAGHRLDLTLTTQAAYDALAPRAVHLAPDELTLGVATDGSAGHVRALLDELDPDRTTVDRFAVRTATLDDVFLTLTGADR
>NZ_CP018870.1|WP_045324392.1|4190186_4190945_-|ABC-transporter-permease
MTAATPVSALALAGRSLRISRRSPDALIAALMLPVMLMLIFVYFFGGAIDTGTEYVTYVVPGAMLLCAGFGAASTAVSVADDMRTGVIDRFRTLDIGGIPILAGHVAASVLRNLLSTTLVLAVALAIGFRPQTGPAAFLAAAGLLLAYITAISWLAAALGLLAKTPEAAGGFTFLMMFLPYPSSAFVPIDTMPSWLHGFAENQPLTPVIESLRALLLAQPAGSTPWTALAWCAGITAAAVTLAGVLFRGRTR
>NZ_CP018870.1|WP_030027023.1|4189866_4190139_+|DUF1876-domain-containing-protein
MATLVGWHVELEFTEEGHRTSAAALVRLGDGSEIRARGYALRHPSDPEQMRVGEEIAGARALMDLAQQMLQKAHSEIDEATGRHSYPLNR
>NZ_CP018870.1|WP_030851864.1|4189043_4189700_+|hypothetical-protein
MPMKPLEHDRRYGELDQVMRAYLGQQGEDTAERRSPALDAYLRHTWHTRPWAIAEAERQLREYSRNPPGRLRIDLGEFYAVPDVGIPQAAIGDWLLVLADHLKQSVEDGEVPPPAIPQTHWEWHARFPEAAQLLGGWFSQDIVDEFPDHEAAVADYAATTDPQLVARLVGELHELIALPLDEGDYALAAAELGMEVNPPEPFSYGAWFQSVATSLAGG
>NZ_CP018870.1|WP_037918680.1|4188731_4189031_+|hypothetical-protein
MLTRSATYPDRETAQWATQQVVTANEQVIHRWLAQGTRARLTIEAAWPSREEPVGRVQLEAMLLAGQGPVDVRAARVVLRREPDSPYGFVVQTTVPFYL
>NZ_CP018870.1|WP_030027026.1|4188097_4188688_+|hypothetical-protein
MSIDQASWEAAVRHLYEDAFSFSATGPRQHDDWQVDVLAVMQRAVPDPRGWAGLDDTANKRSQEHPDFPFCRPSFRDDPSRPLTPADVRERLYGIDRASAENLLLALTDDGCTLRNLARFTESFDELQNMARTILARYGDTSTCYTNVSHIGRIGTLDFTAATSHGWSPMTFYGEDSGLVVVSEAEVGLFWTFGDY
>NZ_CP018870.1|WP_075970799.1|4186281_4188081_+|hypothetical-protein
MAGPTPGPTPAQPPAGGGNIDVKPSSLWTVSGRVAGQQDPMMRGGNTLVQELQKYPDAGGAGTSAEKFAQAYKKIGNRWLEVLGKSVVSIGGVAVGFTETANAYTKADAAAHPKPGKAAEQRPLPTVIDKDPKFASVPDIKWGDDDGGDDLIRGAMEGIPEIVRDVLQPAAKNIFRVGKVADVHPFPQQHYLNSHCHSWMNASTVPGNTAAELTSIIGTITNHGRADWEAAMRTFCSALWGATAWGQSGPSRHGYQWAHTTGPHGAQVATGSQPVMAVLADVAIKISDCLREYAEAAVELNHDISEELKRAMKKAAMSIIDDLEKAKEKPSLKTIAGAVTSVASGAGGAVGLLLKFDVNTVLNLDKAKLNRIVDEYTGIVDGLTTRMEALQKVLDEAHMSAPKFEAGVARAHGFGARSLEDFKSTSQTWLKIDSATGKYVLDLAANEYMADGHTLDKHVGKTDEQLAQRLRDQQDPPTNAWPHGKPTMRASSAFPNYQRAQELTQYNLNHNAAAIDAWIKGPPPPPQNDVRTFTATAPNGEISGRSVSKQPTDPTEPLSGYKQGGLLARAEEVTGIDTRIRYDSNRNPPFTVMTSMPSK
>NZ_CP018870.1|WP_075970804.1|4195765_4196011_-|DUF397-domain-containing-protein
MSATTALKWFKSSYSGGDGDACLEVALSWRKSSYSGSEGGACLEVATGPDTVHVRDSKVQDGPVLALAPASWAALTGWLAR
>NZ_CP018870.1|WP_075970805.1|4196007_4196832_-|helix-turn-helix-transcriptional-regulator
MPPRKRVRPNATTMKMVGSQVAAGRIAKNLTQRQLGELVRLDAETIASIEQGRRALMPNVAELMDQHLGLPGLLTLAANGMPVIDATPPWAEEYMDLEHRAITLSWFDNQVVPGLLQTETYARAVFRCRVPAHPEAEIEALTTRRLARQQILRRSTPPTLSFVVWAAVLRDRLGGDEVYAEQLRHLRACAGLPDVSLQVLPLGRTSHAALDGPFILLETPNHQHHGYTETQRGSHLTSDPDEVSILARKYAMLRTQALNTEQTCGLLDRLAGET
>NZ_CP018870.1|WP_030028038.1|4197129_4197927_-|VOC-family-protein
MNGPYKPGTPCWIDLMVPDQQAALDFYCDLFGWQGEVGPAEQGGYSVCLLKGKPVAGIMKAMNPDGTVPDPMPPTAWTTYLATDSIDSTLKSVTDAGGSVMLGAVDVMDLGRMAVITDPTGAAVGLWQAGTFDGAGIVNEHGALIWSELNTGDVPAAAAFYTSILPVTTAKSQMPGAGEYTEFKVGDRAVGGMMDLANLPDGVPPHWMPYFHVDDVDEIQAATERAGGSVMAPAFDMVAGRMAVLADPQGGVFSVIKATAPEQPA
>NZ_CP018870.1|WP_107069568.1|4198102_4198291_+|hypothetical-protein
MWAETEALQRQLADAGAHQCASPVDLLVAVIARQHGLTVLHQDAGFETIAKVTGRPVRRILG
>NZ_CP018870.1|WP_030028041.1|4198340_4200110_-|arginine--tRNA-ligase
MASVPSLASSVNQRVADALASALPEAGGADPLLRRSDRADFQANGILALAKKAKANPRELATTVVEGIPAGDLIKEIEVSGPGFLNITVADSAIVSTLAARAADDRLGVPLNASAGTTVIDYAQPNVAKEMHVGHLRSAVIGAAMVEILEFTGEKVIRRHHIGDWGTQFGMLIQYLLEHPHELDHKSAGDDEQASGEEAMSNLNRLYKASRALFDSDEEFKTRARARVVDLQAGEAETLALWQRFVDESKIYFYSVFNKLDMDIQDPDVVGESGYNDMLVETCKLLEESGVAVRSNGALCVFFEDVKGPDGNPTPLIVQKSDGGFGYAATDLSAIRDRVTNLGATELIYVVDARQSLHFKMVFETARRAGWLNDDVKAVQLAFGTVLGKDGKPFKTREGETVRLVDLLDEAIERASAVVREKAQDLTEAEIAERGAQVGIGAVKYADLSTSAARDYKFDLDQMVSLNGDTSVYLQYAYARIQSILRKAGDATPAAHPEVALAPTERALGLHLDAFGELIAEAAAEHAPHKLAAYLYQLASLYTSFYSECPVLKADTPEQVENRLFLCELTARTLSKGMSLLGIRTPEKL
>NZ_CP018870.1|WP_075970806.1|4200352_4202092_+|lysine--tRNA-ligase
MAQSAQSSTETDWVSRFADDVIAEAERRAPGKAVVVASGLSPSGPVHLGNLREVMTPHLVADEIRRRGHEVRHLISWDDYDRFRKVPKGIPGVTEESHARHIGRPLTAVPAPEGSAYPNWAEHFKAAMAESLAELGVEYDPISQTEQYTTGVYREQILHAMKHRGDIDAVLAQYRTKAKPGGKKPQQKQVDEAELEAAEGSGAAAEDDGSAGEGGYFPYKPYCGQCGKDFTKVTSYDDETTEMTYVCTEDEFTETVKLSEFNRGKLVWKVDWPMRWAFEGVIFEPSGVDHSSPGSSFQVGGQIVHIFGGEQPIGPMYAFVGISGMAKMSSSKGGVFTPGDALKIMEPQLLRWLYARRRPNQSFKIAFDQEIQRLYDEWDKLEAKVADGSVLPADAAAHSRAVRVASHELPRTPRPMPYRTLASVVDITAGHDEQTLRILSDLEPDKPLTSLDEVRPRLDRAENWITTQVPADQRTLVREDPDTELLTSLDDEGRESLRLLLEGLDSHWSLDGLTTLVYGVPKVMAGLEPDAKPTPELKVAQRTFFALLYRLLVTRETGPRLPTLLLAVGADRVRKLLAV
>NZ_CP018870.1|WP_045321424.1|4202179_4203499_-|DUF2637-domain-containing-protein
MAAMQLTRTHRILIGVVVAGAVVIAGIGFAGSYAAVRELAEKKGFGSFSLVFPIGIDAGICVLLALDLLLTWMRIPFPLLRQTAWLLTAATIAFNGAASWPDPLGVGMHAVIPILFVVTVEAARHAVGRIADITADRHMEGVRITRWLLSPLPTFKLWRRMKLWELRSYEQAIGMEQDRLIYQARLQARYGRFWRQKAPVEALMPLKLARIGVPLSQTAPDALAATGIDPAVLPPLEQQLAGSAPALEVSAAGAADPLQAQAQQPVQAPQSAVQQGAPGAVAAHVPPAFAVDPTAMPAAHNSAWFAAPKAPQAAYEGGYNPQYVEGLEPTPVLPPMGPEEPQAQQLPIPEPRHEAAADGQFPEQVPVVDSPDEVEFAQIAYKVFCALAEETQDYPTAEALDIMLADRYGVTHPRSGSLLRRMISSFRQQHHKDREAEPA
>NZ_CP018870.1|WP_045321423.1|4203631_4204399_-|DUF3558-family-protein
MHRSASRLTRVLACAAVPVILTVAGCSSDSGKDSASKGDKKSGSSASSKPGEKAKKPELEKAAFAALPDPCKAIQTATIETLVPEAKDKNGTATKSNDLATRASCSWNGLDEDGLKGSQYRWLSLSFFRTDSHASLGSANKRAEEQYGKQVEAAKATEGAQNVKAEPVEGLGDQGTSVVYSVKKDVDFFNTTVVARSQNVVVTLDYNGAAYEGAGAPDQAKLLQDALTAAKEAVASIGTANKPAEQPQPESPQPQ
>NZ_CP018870.1|WP_107484917.1|4204512_4205376_-|hypothetical-protein
MLTALAAGAAGLTGCTGGGDGAGTSDSKAGGGTAAPAQPGKYRSLPAPCRAAADSKKLKAMLPEPDGLTPEQLDQLYAGVADSSYDGDRHVGCRWTAQTPEETRLLSVGFERVVSYDRATTSDDDKAKQVYVRLLTDAHLPFPGPATTPGPGAANPANPANPPASSPPPANAAPPANAAPPASGAPSAGAPAAGTPAPGASPSSQPELGSRVLEGLGTEAFLDDKLSPAGATAAQSRTVRIVFRTSNVIVKVEYSVQPALPGTVPPSAEIQDKARQLALALVDRFNE
>NZ_CP018870.1|WP_075970807.1|4205608_4206802_+|RtcB-family-protein
MSYVEVPGAQVPIRMWTDPASVEAGAMQQLHNVATLPWIKGLAVMPDVHYGKGATVGSVIAMKDAVCPAAVGVDIGCGMSAVKTSLTANDLPGDLSKLRSKIEQAIPVGNGMHREAVDPARLYGFTEAGFGDLWERFDYVADAVKFRRDRAMRQMGSLGQGNHFCEVCIDTSGSVWLMLHSGSRNIGNELAAFHIGVARGLSHNQNLVDRDLAVFLAATPEMEAYRNDLFWAQEYAKYNRAVMMSLFKEVFRKEFRKAKVSFDREISCHHNYVAEERYDGMDLLVTRKGAIRAGSGDYGIIPGSMGTGSYIVKGLGNEKSFNSASHGAGRKMSRTAAKKKFSARDLAEQTKGVECRKDSGVVDEIPGAYKSIEQVIDQQTDLVQVVAKLKQVICVKG

Crispr_ID: NZ_CP018870_14

• CRISPR_ID: NZ_CP018870_14
• CRISPR_location: 4318341-4318430
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_14

Consensus_repeat	Method
CGCGGGCGTTCGAGGCGCGGGGTC	CRISPRCasFinder

spacers of NZ_CP018870_14

>14.1|4318365|42|NZ_CP018870|CRISPRCasFinder
TTGGTCCGGACTCGGGAGTGGGCGCCGGCCCATTTCCGGCCT

CRISPR arrays and Neighbor proteins around NZ_CP018870_14

CRISPR arrays

The CRISPR arrays of NZ_CP018870_14

>merge|NZ_CP018870|14|4318341-4318430|CRISPRCasFinder
CGCGGGCGTTCGAGGCGCGGGGTCTTGGTCCGGACTCGGGAGTGGGCGCCGGCCCATTTCCGGCCTCGCGGGCGTTCGAGGCGCGGGGTC

>NZ_CP018870|14|13|4318341-4318430|CRISPRCasFinder
CGCGGGCGTTCGAGGCGCGGGGTC	TTGGTCCGGACTCGGGAGTGGGCGCCGGCCCATTTCCGGCCT
CGCGGGCGTTCGAGGCGCGGGGTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_075970834.1|4306169_4308176_-|CocE/NonD-family-hydrolase	unknown	unknown	gnl|CDD|225487
NZ_CP018870.1|WP_030026963.1|4315418_4317362_-|2-oxoacid:acceptor-oxidoreductase-subunit-alpha	unknown	unknown	gnl|CDD|274738
NZ_CP018870.1|WP_075970838.1|4326567_4328628_+|NADH-quinone-oxidoreductase-subunit-L	unknown	unknown	gnl|CDD|235836
NZ_CP018870.1|WP_075970836.1|4322585_4324010_+|dehydrogenase	unknown	unknown	gnl|CDD|376317
NZ_CP018870.1|WP_030037399.1|4320268_4321450_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NZ_CP018870.1|WP_030026970.1|4309667_4310879_+|membrane-protein	unknown	unknown	gnl|CDD|225390
NZ_CP018870.1|WP_107484918.1|4325600_4326200_+|NADH-quinone-oxidoreductase-subunit-J	unknown	unknown	gnl|CDD|376343
NZ_CP018870.1|WP_037660968.1|4313232_4314177_-|EamA-family-transporter-RarD	unknown	unknown	gnl|CDD|225510
NZ_CP018870.1|WP_030033145.1|4324006_4324975_+|NADH-quinone-oxidoreductase-subunit-H	unknown	unknown	gnl|CDD|376297
NZ_CP018870.1|WP_045322796.1|4318532_4319834_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|379374
NZ_CP018870.1|WP_030037398.1|4321597_4322005_+|NAD(P)H-quinone-oxidoreductase-subunit-3	unknown	unknown	gnl|CDD|169084
NZ_CP018870.1|WP_045323938.1|4321995_4322589_+|NADH-quinone-oxidoreductase-subunit-B	unknown	unknown	gnl|CDD|235797
NZ_CP018870.1|WP_045323939.1|4324974_4325586_+|NADH-quinone-oxidoreductase-subunit-I	unknown	unknown	gnl|CDD|235637
NZ_CP018870.1|WP_030026965.1|4314346_4315426_-|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta	unknown	unknown	gnl|CDD|237006
NZ_CP018870.1|WP_030026968.1|4311195_4311600_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030031732.1|4326199_4326571_+|NADH-quinone-oxidoreductase-subunit-NuoK	unknown	unknown	gnl|CDD|180218
NZ_CP018870.1|WP_030026967.1|4311681_4312998_-|M28-family-peptidase	unknown	unknown	gnl|CDD|349873
NZ_CP018870.1|WP_030026969.1|4310917_4311187_+|hypothetical-protein	unknown	unknown	gnl|CDD|117819
NZ_CP018870.1|WP_075970835.1|4317513_4318185_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP018870.1|WP_030026971.1|4308416_4309427_+|polyprenyl-synthetase-family-protein	unknown	unknown	gnl|CDD|223220

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_075970834.1|4306169_4308176_-|CocE/NonD-family-hydrolase	gnl|CDD|225487	COG2936, COG2936, Predicted acyl esterases [General function prediction only].	4.43846e-111
NZ_CP018870.1|WP_030026963.1|4315418_4317362_-|2-oxoacid:acceptor-oxidoreductase-subunit-alpha	gnl|CDD|274738	TIGR03710, OAFO_sf, 2-oxoacid:acceptor oxidoreductase, alpha subunit. This family of proteins contains a C-terminal thiamine diphosphate (TPP) binding domain typical of flavodoxin/ferredoxin oxidoreductases (pfam01855) as well as an N-terminal domain similar to the gamma subunit of the same group of oxidoreductases (pfam01558). The genes represented by this model are always found in association with a neighboring gene for a beta subunit (TIGR02177) which also occurs in a 4-subunit (alpha/beta/gamma/ferredoxin) version of the system. This alpha/gamma plus beta structure was used to define the set of sequences to include in this model. This pair of genes is not consistantly observed in proximity to any electron acceptor genes, but is found next to putative ferredoxins or ferredoxin-domain proteins in Azoarcus sp. EbN1, Bradyrhizobium japonicum USDA 110, Frankia sp. CcI3, Rhodoferax ferrireducens DSM 15236, Rhodopseudomonas palustris BisB5, Os, Sphingomonas wittichii RW1 and Streptomyces clavuligerus. Other potential acceptors are also sporadically observed in close proximity including ferritin-like proteins, reberythrin, peroxiredoxin and a variety of other flavin and iron-sulfur cluster-containing proteins. The phylogenetic distribution of this family encompasses archaea, a number of deeply-branching bacterial clades and only a small number of firmicutes and proteobacteria. The enzyme from Sulfolobus has been characterized with respect to its substrate specificity, which is described as wide, encompassing various 2-oxoacids such as 2-oxoglutarate, 2-oxobutyrate and pyruvate. The enzyme from Hydrogenobacter thermophilus has been shown to have a high specificity towards 2-oxoglutarate and is one of the key enzymes in the reverse TCA cycle in this organism. Furthermore, considering its binding of coenzyme A, it can be reasonably inferred that the product of the reaction is succinyl-CoA. The genes for this enzyme in Prevotella intermedia 17, Persephonella marina EX-H1 and Picrophilus torridus DSM 9790 are in close proximity to a variety of TCA cycle genes. Persephonella marina and P. torridus are believed to encode complete TCA cycles, and none of these contains the lipoate-based 2-oxoglutarate dehydrogenase (E1/E2/E3) system. That system is presumed to be replaced by this one. In fact, the lipoate system is absent in most organisms possessing a member of this family, providing additional circumstantial evidence that many of these enzymes are capable of acting as 2-oxoglutarate dehydrogenases and.	0
NZ_CP018870.1|WP_075970838.1|4326567_4328628_+|NADH-quinone-oxidoreductase-subunit-L	gnl|CDD|235836	PRK06590, PRK06590, NADH:ubiquinone oxidoreductase subunit L; Reviewed.	2.77987e-147
NZ_CP018870.1|WP_075970836.1|4322585_4324010_+|dehydrogenase	gnl|CDD|376317	pfam00329, Complex1_30kDa, Respiratory-chain NADH dehydrogenase, 30 Kd subunit.	6.13462e-42
NZ_CP018870.1|WP_030037399.1|4320268_4321450_-|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	4.81523e-33
NZ_CP018870.1|WP_030026970.1|4309667_4310879_+|membrane-protein	gnl|CDD|225390	COG2834, LolA, Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane].	1.21359e-08
NZ_CP018870.1|WP_107484918.1|4325600_4326200_+|NADH-quinone-oxidoreductase-subunit-J	gnl|CDD|376343	pfam00499, Oxidored_q3, NADH-ubiquinone/plastoquinone oxidoreductase chain 6.	9.12519e-31
NZ_CP018870.1|WP_037660968.1|4313232_4314177_-|EamA-family-transporter-RarD	gnl|CDD|225510	COG2962, RarD, Predicted permeases [General function prediction only].	5.42965e-96
NZ_CP018870.1|WP_030033145.1|4324006_4324975_+|NADH-quinone-oxidoreductase-subunit-H	gnl|CDD|376297	pfam00146, NADHdh, NADH dehydrogenase.	1.83134e-109
NZ_CP018870.1|WP_045322796.1|4318532_4319834_-|sensor-histidine-kinase	gnl|CDD|379374	pfam13796, Sensor, Putative sensor. This family is often found at the N-terminus of proteins containing pfam07730 and pfam02518. The N-termini of proteins containing these two domains often function in stimulus sensing.	3.86785e-41
NZ_CP018870.1|WP_030037398.1|4321597_4322005_+|NAD(P)H-quinone-oxidoreductase-subunit-3	gnl|CDD|169084	PRK07756, PRK07756, NADH-quinone oxidoreductase subunit A.	4.92348e-35
NZ_CP018870.1|WP_030031732.1|4326199_4326571_+|NADH-quinone-oxidoreductase-subunit-NuoK	gnl|CDD|180218	PRK05715, PRK05715, NADH-quinone oxidoreductase subunit NuoK.	1.25582e-35
NZ_CP018870.1|WP_045323939.1|4324974_4325586_+|NADH-quinone-oxidoreductase-subunit-I	gnl|CDD|235637	PRK05888, PRK05888, NADH-quinone oxidoreductase subunit NuoI.	4.34613e-42
NZ_CP018870.1|WP_030026965.1|4314346_4315426_-|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta	gnl|CDD|237006	PRK11867, PRK11867, 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed.	2.39261e-174
NZ_CP018870.1|WP_045323938.1|4321995_4322589_+|NADH-quinone-oxidoreductase-subunit-B	gnl|CDD|235797	PRK06411, PRK06411, NADH-quinone oxidoreductase subunit NuoB.	2.69501e-88
NZ_CP018870.1|WP_030026967.1|4311681_4312998_-|M28-family-peptidase	gnl|CDD|349873	cd03876, M28_SGAP_like, M28 Zn-peptidase Streptomyces griseus aminopeptidase and similar proteins. Peptidase family M28; Streptomyces griseus Aminopeptidase (SGAP, Leucine aminopeptidase (LAP), aminopeptidase S, Mername-AA022 peptidase) subfamily. SGAP is a di-zinc exopeptidase with high preference towards large hydrophobic amino-terminal residues, with Leu being the most efficiently cleaved. It can accommodate all except Pro and Glu residues in the P1' position. It is a monomeric (30 kDa), calcium-activated and calcium-stabilized enzyme; its activation by calcium correlates with substrate specificity and it has thermal stability only in the presence of calcium. Although SGAP contains a calcium binding site, it is not conserved in many members of this subfamily. SGAP is present in the extracellular fluid of S. griseus cultures.	1.61596e-139
NZ_CP018870.1|WP_030026969.1|4310917_4311187_+|hypothetical-protein	gnl|CDD|117819	pfam09274, ParG, ParG. Members of this family of plasmid partition proteins adopt a ribbon-helix-helix fold, with a core of four alpha-helices. They are an essential component of the DNA partition complex of the multidrug resistance plasmid TP228.	0.000628962
NZ_CP018870.1|WP_075970835.1|4317513_4318185_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.08973e-37
NZ_CP018870.1|WP_030026971.1|4308416_4309427_+|polyprenyl-synthetase-family-protein	gnl|CDD|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	2.11815e-88

Protein sequences

>NZ_CP018870.1|WP_075970835.1|4317513_4318185_-|response-regulator-transcription-factor
MEDRVRVVIAEDSVLLREGLTRLLTDRGHDVVAGVGDAEALIKTVAELAAEDALPDVVVADVRMPPTHTDEGVRAAVRLRRDHPGIGVLVLSQYVEEQYATELLAGSSTGVGYLLKDRVAEVREFLDAVVRVARGGTALDPEVVAQLLGRSRKQDVLAGLTPREREVLGLMAEGRTNSAVAKQLVVSDGAVEKHVSNIFMKLGLSPSDGDHRRVLAVLTYLKS
>NZ_CP018870.1|WP_030026963.1|4315418_4317362_-|2-oxoacid:acceptor-oxidoreductase-subunit-alpha
MTSQVSSPAEQADGAGGATVGGQRTPGSPDGKEVRRLDRVIIRFAGDSGDGMQLTGDRFTSETASFGNDLSTLPNFPAEIRAPAGTLPGVSSFQLHFADHDILTPGDAPNVLVAMNPAALKANIADVPRGAEIIVNTDEFTKRPMAKVGYETSPLEDGSLAGYNLHPVPLTTLTVEALKDFGLSRKEAERSKNMFALGLLSWMYHRPTEATESFLRQKFAKKPEIAEANIVAFRAGWNFGETTEDFAVSYEVAPATQAFPTGTYRNISGNLALSYGLIAASQQAELPLYLGSYPITPASDILHELSKHKNFGVRTFQAEDEIAGIGAALGAAFGGALGVTTTSGPGVALKSETIGLAVSLELPLLIVDIQRGGPSTGLPTKTEQADLLQAMYGRNGEAPVPIVAPRTPADCFDAALDAARIALTYRTPVFLLSDGYLANGSEPWRIPEVADLPDLKVKFAAATNHTLADGSEVFWPYKRDPQTLARPWAVPGTPGLEHRIGGIEKQDGTGNISYDPANHDFMVRTRQAKVDGIEVPELDVDDPDGASTLVLGWGSTYGPITAAVRRVRGAGLPVAQAHLRHLNPFPRNLGEVLERYEKVVVPEMNLGQLATLIRAKYLVDARSYNQVNGMPFKAEQLAKVLKEAIDD
>NZ_CP018870.1|WP_030026965.1|4314346_4315426_-|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta
MTEVTEATDGARTLLSLVPKAESKQSMKDFKSDQEVRWCPGCGDYAVLAAVQGFMPELGLAKENIVFVSGIGCSSRFPYYMNTYGMHSIHGRAPAIATGLATSRRDLSVWVVTGDGDALSIGGNHLIHALRRNVNLKILLFNNRIYGLTKGQYSPTSEIGKITKSTPMGSLDAPFNPVSLAIGAEASFVARTVDSDRKHLTEVLRQAADHPGTALVEIYQNCNIFNDGAFEVLKDKDQAREAVIRLEHGRPIRFGADDEKGVVRNQATGELEVVEVTPANEGQVLVHDARTASPTTAFALSRLADPDTLHRTPIGVFRSVERPVYDTLMADQLDAAVDRGGKGDLGALLNGNDTWTVVG
>NZ_CP018870.1|WP_037660968.1|4313232_4314177_-|EamA-family-transporter-RarD
MKAENEQRAGLLYGFGAYGIWGLVPLFWPLLMPAGAVEILAHRMTWSLAVVGLALLAVRRWGWIRELARQPRKLGLTALAASVISVNWGLYIWSVNNGHVVESSLGYFINPLVSIAMGVLVLGERLRRAQWVAVGVSAVAVLVLAVGYGRPPWISLALACSFATYGLIKKKLNMGGLESLAAETAMLFLPALGYLLWLGAQGRSSFASQGVGHALLLAATGLVTAIPLVFFGAAAIRVPLSTLGLLQYMAPVFQFGLGVLYFHEAMPPERWAGFSLVWAALAILTWDALRTARRSRARLEAAPAAVPAPAREPA
>NZ_CP018870.1|WP_030026967.1|4311681_4312998_-|M28-family-peptidase
MSLSVSRRLAAVTALAVAGLFASAAPAALAAPTAVAAAPTPPDIPLANVKAHLSQLSTIAANNGGNRAHGRPGYKASIDYVKAKLDAAGFTTTLQTFTSSGSTGYNLIADWPGGDPNSVLMAGAHLDSVTSGAGINDNGSGSAAVLETALAVSRAGLQPTKHLRFGWWGAEELGLIGSRYYVNNLPTAERAKFAGYLNFDMIGSPNPGYFVYDDDPTIEQTFKNYYAGIGVPTEIETEGDGRSDHASFKNVGIPVGGLFTGASNTKSSAQAQKWGGTAGQSFDRCYHSSCDNTSNINDTALDRNADAIAYAIWNLGASTPVPPGPSFENTADVAIPDSPAAAVTSPITVSGVAGNAPATTKVDVNIVHTYRGDLVVDLLAPDGTVYNLHNRSGGSADNLVQSYTVNASSEVANGIWKLRVKDSAAQDVGYINSWKITF
>NZ_CP018870.1|WP_030026968.1|4311195_4311600_+|hypothetical-protein
MEWAWTALAHHLPSDPAVWDPSGVAAAVARHQNDLVMVPEQPAPDTAWRAAAFLHTLAVCPALESPMNEFYAAAATRSYLRVAGAAKLPSPEELGDLVEAAKLGRADVAAVAAELRARMREPLEASSRGRAEDA
>NZ_CP018870.1|WP_030026969.1|4310917_4311187_+|hypothetical-protein
MSLPTLASLPVPVQRARCTVLGMSRHVTIRLDEEFHERLKARAAALGTTVTALITEVTERELDEDRKNFLSGIEEFADHWGYFQERFGN
>NZ_CP018870.1|WP_030026970.1|4309667_4310879_+|membrane-protein
MAANTKTSRKAARYAVPVAVAGVAAASVAMVPAFANSGGPDLPKVTAQQLIEKVAASEVEQLSGTAKISTDLGLPKLASGLLGGGGVAGGSANPEDKVAQLANGTHTFRVAADGEDRQRLTFLDGKDEYSLIHNGDDVWGYDSKSNEVFHEKASSADRAGKGEGKEHKTGDRLAASPQKLAEEILAAAGPTTDISVGETAQVAGRDAYQLVLKPKQAGSTVGSVQIAVDAGNGVPLRVRLLSAQGGKPIVDAGFTKVDFAKPSADTFAFTPPKGAKVTEGADGHGQGDKGGAFKALESFPGLDGLAGGPGGKGDVKVLGEGWATIARIDSGAGRSLKDLENDKNAPKEAKQFLDSLGDKVNGKFGEGRVMSTRLFNVLVTDDGKVYAGAVTKDSLVKAADADK
>NZ_CP018870.1|WP_030026971.1|4308416_4309427_+|polyprenyl-synthetase-family-protein
MTVVGPFGLSVRDQALETDVQAGLAAVEAGLLEATKSEVPFITEAAQHLVRAGGKRFRPLLVMLASRFGDPYAPGIVPSAVVVELTHLATLYHDDVMDEADVRRGVESANARWGNSVAVLTGDFLFARASHILADLGPEAVRIQAEAFERLVTGQILETAGPRDGRDPVAHYLDVIAGKTGSLIAVSGRFGALMSGADESVVDILTQYGERLGTAFQLADDVLDIASDAHESGKTPGTDLREGIPTLPVLRLREMAARDGRPEDLELVALLDGDLTDDARHAEVLTRLRAHPALEQARRDTIRYAQDARATLAPLPECFAKAALEELCDAVVHRAG
>NZ_CP018870.1|WP_075970834.1|4306169_4308176_-|CocE/NonD-family-hydrolase
MIIRTEFPYGTTREDVRIPLPDGVELYARIWRPVTDQPVPALLEYLPYRLTDWTAPRDWQRHPWYAGHGYASVRVDVRGHGCSGGQPGDEYDARELADGVAVVEWLAAQEWCTGSVGMFGISWGGCNALQIAALAPEPLKAVVTVCSTDDRYDNDVHYMGGSVLAVDMHAWAATMLAFASRPPDPLHAGDGWRAQWLDRLEAVEPLIHTWLSHQTRDAYWRHGSVCEDYGAIGAAVLAVGGWHDPYRDTVLRLVEHLPKDRVRGLIGPWSHQYPDRGLPPGPAIGFLQETLRWWDHWLKGADTAVLEEPLLRAWISDAHPPATVYEELPGRWVGERAWPSPTVIPVPYVFQGPPVAVASPQHTGLDAGRFFPFGNDADLPPDQREEDAKSACFEFPVSGAEPVEILGRPSVTLRLRLDVPYGQVVARLCDVAPDGSSTLVTRGALNLSARQGRDRAVPWPVGSYEDVSFELNGIGHAFPPGHRIRLAVSSAYWPWIWPRAGSEAGWTLDPVGSSVTLPVRAASPAGEAGIVFEPPEQAPPLGVSVPATLDEPGPERLVVRDVARGTWRLEVDPRYGGTRVYPDGLEYGEEATEVYEIQDGDPLSARARSQWRIRLHRPDSGWEARVETSSEIRCDEGGFLTADEVVCREGDEVVFHRTWERRIPRAAG
>NZ_CP018870.1|WP_045322796.1|4318532_4319834_-|sensor-histidine-kinase
MDDGKSGRGGAGAVLWAPVAGRTWREFAYLLVGMPLSTLYFSLAITGVSLGAGLLVTFLGVPVLAGTLAMCRGFGRLERARVRALLGADIAEPAPIRAKKSGPLAAMGAVLMSGSAWRHLLYSVIHFPWAVFGFCLALTFWAAGWAYLLYPVWFWVFPAFTDQPGLQLFQNDDYSLYLDSPAEIALTCLVGLAFTLATPWVIRALTTVDRVMVGGLLGASRLDSRVTELESDRGVVVDTAAADLRRIERELHDGAQARLVSLAMDLGMAREKLAADPRAAARLVDEAHGEVKIALQELRDLARGIHPAVLTDRGLDAALSAVASRCAAPVRVAVDLPARPAAAIEGIAYFTVSELLQNISRHAGARSATVDVWKSGERLLLQVSDDGRGGAHASGGSGLAGLAERLDAVDGVLVVDSPEGGGTTVTAELPWRA
>NZ_CP018870.1|WP_030037399.1|4320268_4321450_-|sensor-histidine-kinase
MTMSHAVPDNDRPPPVRPVFSAVTWKEIAHLVSNLPEGIIGFVYAVVMVSTAGGLSVTAIGLPLLAVGLFLSRQWGRLERGRARWLLGVRVEEPTPIPGPRRSGGFFPWLWTSIKDPVGWRTVLYQLIRLPWGVLTFTVVLTGLFVLWPVLPYLVRLLANADRAMVRGLLSPSDDLERRIAELESDRGVVVDTAAADLRRIERDLHDGAQARLVALAMGLGLAKEKLLEDPEGAAAMVDEAHGEVKLALQELRDLARGIHPAVLTDRGLDAALSSVAARCVVPVKVLVDLPSGQEARPAEAIEGIAYFVVSELLQNVSKHARARGATVEVWRAGARLLIRVSDDGRGGAGTSGGSGLAGLAERLDAVDGVLVVDSPEGEGTVVTAELPWRGRG
>NZ_CP018870.1|WP_030037398.1|4321597_4322005_+|NAD(P)H-quinone-oxidoreductase-subunit-3
MSEPTVSTVTVLAADYFRSYSVVGLLAALGVLFVAVAFGAGRLLRPVVPTREKLLTYECGVDPVGEGWAHTQVRYYVYAFLYVIFAVDSIFLFPWATVFAAAGYGATTLVEMFVFLGFLAVGLLYAYKKGVLEWT
>NZ_CP018870.1|WP_045323938.1|4321995_4322589_+|NADH-quinone-oxidoreductase-subunit-B
MDVTPQPELLPEPKRLGVLSRLAPEPMKVVLNWGRRYSLWVFNFGLACCAIEFIAASMARHDFIRLGVIPFAPGPRQADLMIVSGTVTDKMAPAVKRLYEQMPEPKYVISFGACSNCGGPYWDSYSVTKGVDQIIPVDVYVPGCPPRPEALLQGILKLQEKIARESLAERYATAPSVSQLTSGLVTPPPAPTGEAGA
>NZ_CP018870.1|WP_075970836.1|4322585_4324010_+|dehydrogenase
MNLYDSLPDAAPTVFGAEAVAELSYDVLTVDVPVGSWIPSLEIARDKLGCTYFDWLSAVDEPGTGFRVCAHVASLENGRVRRLLLRTTVPHGAPSLPSAVAVYAGAEWHERETFEMFGITFTDHPNLVHLLLPENFEGHPLRKDFVLAARVAKAWPGAKEPGEAHDPDAPKRRQMLPPGVPDPNDWGPLKGQLPPAPARPARTPRAAGAAGAAARTPREGAPVRRTRSVAEGSATQAGEAAVPEAPARPPRRTRSVADGSASQAAAGGTQTPGAGGQADAPARPARRTRSAADGSASQAPDAAAANDAVNDAAPGTEAPGTEAPGAQAPDGPVPDAPARAPRRTRSAADGSASQAAEAAPGTDAAGPDTGAPAAEPAARAPRRAAPRSSDAPWHDPKPAFDEPAPGPAPKAAPEAGPAPEPEAGPAPEPEAGPAPETEAGPAPETEAGPAPGRRPTEPETETRTDPTTDKGGDA
>NZ_CP018870.1|WP_030033145.1|4324006_4324975_+|NADH-quinone-oxidoreductase-subunit-H
MNDVLDVALRLIVVFAVFLVLPLVVGQTEHKVMAHMQGRLGPMYAGGFHGWAQLVADGVKFAQKEDVVPAGADRRIFQLAPAVALLPYLLVLLAIPIGPGEGAVGQAIDAGVFFVLAVMGVGVLGSLMAGWASANKFSLLGGLRTAAQLLAYELPMLLAAASVAMAAGTVSLNGIVEGFEWWWLPWQITGALVFFTAGLAELQRPPFDMPVADSEIIFGAYTEYTGLRFALFLLAEYAGIVVLCFLTTVLFLGGWHGPFGADGLGWVWTLLKTAVLAFVVIWLRVSYPRLREDQLQKLAWTTLIPLALAQIALTGIVKVAIQ
>NZ_CP018870.1|WP_045323939.1|4324974_4325586_+|NADH-quinone-oxidoreductase-subunit-I
MPIPGSGLAKGLAVTLRTMTKRSHTAQYPEVQPELPPRSRGVIGLFEENCTVCMLCARECPDWCIYIDSHKETVPASTPGGRERSRNVLDRFAIDFSLCMYCGICIEVCPFDALFWSPEFEYAETDIHELTHERDKLREWMWTVPAPPALDPAAEEPKEVAAARKAAEKAEAAAVAAAAAAAAETAQAADDEPPTTPTAEGDA
>NZ_CP018870.1|WP_107484918.1|4325600_4326200_+|NADH-quinone-oxidoreductase-subunit-J
MAAAATAGPGFLSPTGVEIAFLLVGLATFGAALVTVTTRQLVHAALWLVVALGGIAVEYLLLTAEFIAWVQVLIYLGSVIVLLLFGLMLTKAPIGRSPDADSGNRPVALGVAVVAAAALVWVVVDAFRTTWIDLDGPVQGSTKVSGEMLFQHWVLPFEALSVLLLAALIGAIVLSRRNDPADPAASDTGGAAARDKGQR
>NZ_CP018870.1|WP_030031732.1|4326199_4326571_+|NADH-quinone-oxidoreductase-subunit-NuoK
MHLAYPAVLAALLFCTGLYGVLARRNAILVLMSVELMLNAVNLNLVAFDVWLRDTLHAGQALTLFTIAIAAAEIGIGLAIVLMVYRNRGTSDVDRLRDTAEGHEPHPNDAGDSTGTARPEVAA
>NZ_CP018870.1|WP_075970838.1|4326567_4328628_+|NADH-quinone-oxidoreductase-subunit-L
MSTTTLAVLVPLLPFLGAVAGLLLGRTAPGFVRPLAILPTLAAAVLAVTVAVRQGGGQPISTATELTPTGSVPIDLSLYIDGFAALVAVLVGVVATCVQLYSTAYLREDPRYPSYAALVSLFTSAMLLVVYSGDLMVLLVGWEVMGICSYFLVGHYWETRAARSASLKAFLVTKLGDVPFLIGLFALATDAGSFRITKILGTVAAGGLDHPTLIALLLLAGVAGKSAQFPLHTWLPDAMAGPTPVSALIHAATMVAAGVYFIARLLPVFAASAAALVVMAVMAALTMVGSALAALAQDDIKRVLAYSTIGQLAYMTGALAVGDRGAAVFHLLSHGAFKALLFLGAGVIIHAAGTNSLAAMSRMDGLAKRIPDAFWTMTLALLALAAIPPFAGFFSKEAVLVAAEQTATGHSDLAPEAAGWLVLVAGVLTALLTAAYAARLWLMAFRGRGAAAPDHGREPLAMTGVLWLLAVPTVAFGLAAGPIADWFDGGALTPTVATSVLGTGAAVIGAMLTYALWQRAGAKAAAAPAGQAPVGRAAGEPAAEQPAAVAATVSAATAAAESAAETPEVAEVTHEHPAVPAGPAADPGRALLGPLHRHAADGFHLDAVYDRLFVRPVRGAASLVRFLDREVVDTYVRGAGSGTRLLGGLVRRAQTGNVQSYLSALLAGAVVLAIATAVLANVNAGS

Crispr_ID: NZ_CP018870_15

• CRISPR_ID: NZ_CP018870_15
• CRISPR_location: 4540336-4540426
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_15

Consensus_repeat	Method
ACTGGAACACCCCACGGCGCAGGAGGAGCGCC	CRISPRCasFinder

spacers of NZ_CP018870_15

>15.1|4540368|27|NZ_CP018870|CRISPRCasFinder
ACGCCGAAAACTAGTGGCCGGCCAGGC

CRISPR arrays and Neighbor proteins around NZ_CP018870_15

CRISPR arrays

The CRISPR arrays of NZ_CP018870_15

>merge|NZ_CP018870|15|4540336-4540426|CRISPRCasFinder
ACTGGAACACCCCACGGCGCAGGAGGAGCGCCACGCCGAAAACTAGTGGCCGGCCAGGCACTGGAACACCCCGCGGCGCAGGAGGAGCGCC

>NZ_CP018870|15|14|4540336-4540426|CRISPRCasFinder
ACTGGAACACCCCACGGCGCAGGAGGAGCGCC	ACGCCGAAAACTAGTGGCCGGCCAGGC
ACTGGAACACCCCGCGGCGCAGGAGGAGCGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_030027613.1|4545660_4546239_-|VanZ-family-protein	unknown	unknown	gnl|CDD|377417
NZ_CP018870.1|WP_030027611.1|4545421_4545622_-|PspC-domain-containing-protein	unknown	unknown	gnl|CDD|377200
NZ_CP018870.1|WP_030027606.1|4541672_4542041_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380395
NZ_CP018870.1|WP_030027609.1|4544271_4544520_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030027198.1|4529428_4530544_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|226962
NZ_CP018870.1|WP_030027615.1|4547233_4548196_+|deoxyribose-phosphate-aldolase	unknown	unknown	gnl|CDD|235387
NZ_CP018870.1|WP_030027607.1|4542135_4542870_-|hypothetical-protein	unknown	unknown	gnl|CDD|223477
NZ_CP018870.1|WP_045323125.1|4537217_4537931_-|L,D-transpeptidase-family-protein	unknown	unknown	gnl|CDD|341130
NZ_CP018870.1|WP_045323119.1|4544636_4545416_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030027202.1|4533684_4534275_+|Uma2-family-endonuclease	unknown	unknown	gnl|CDD|99749
NZ_CP018870.1|WP_075970885.1|4531799_4532198_+|cytidine-deaminase	unknown	unknown	gnl|CDD|180142
NZ_CP018870.1|WP_030027203.1|4534573_4535584_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|236196
NZ_CP018870.1|WP_030027616.1|4548201_4549638_+|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143429
NZ_CP018870.1|WP_075970887.1|4538020_4539316_-|MFS-transporter	unknown	unknown	gnl|CDD|340882
NZ_CP018870.1|WP_075972166.1|4535791_4537141_+|MFS-transporter	unknown	unknown	gnl|CDD|340887
NZ_CP018870.1|WP_075970888.1|4546315_4546975_-|PH-domain-containing-protein	unknown	unknown	gnl|CDD|371225
NZ_CP018870.1|WP_030027201.1|4532310_4533588_+|thymidine-phosphorylase	unknown	unknown	gnl|CDD|180276
NZ_CP018870.1|WP_030027608.1|4542983_4544132_+|adenosine-deaminase	unknown	unknown	gnl|CDD|236480
NZ_CP018870.1|WP_078849136.1|4534318_4534687_+|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|379202
NZ_CP018870.1|WP_075970884.1|4530540_4531803_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224005

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_030027613.1|4545660_4546239_-|VanZ-family-protein	gnl|CDD|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	3.87694e-22
NZ_CP018870.1|WP_030027611.1|4545421_4545622_-|PspC-domain-containing-protein	gnl|CDD|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	1.99777e-20
NZ_CP018870.1|WP_030027606.1|4541672_4542041_-|cupin-domain-containing-protein	gnl|CDD|380395	cd06990, cupin_DUF861, domain of unknown function DUF 861, cupin domain. This family contains proteins which seem to be specific to bacteria and some fungi. The function of this family is unknown but contains a cupin domain without a metal binding site. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin (cupa is the Latin term for small barrel).	8.11476e-54
NZ_CP018870.1|WP_030027198.1|4529428_4530544_+|ABC-transporter-permease	gnl|CDD|226962	COG4603, COG4603, ABC-type uncharacterized transport system, permease component [General function prediction only].	2.26591e-71
NZ_CP018870.1|WP_030027615.1|4547233_4548196_+|deoxyribose-phosphate-aldolase	gnl|CDD|235387	PRK05283, PRK05283, deoxyribose-phosphate aldolase; Provisional.	3.38574e-75
NZ_CP018870.1|WP_030027607.1|4542135_4542870_-|hypothetical-protein	gnl|CDD|223477	COG0400, COG0400, Predicted esterase [General function prediction only].	0.00635856
NZ_CP018870.1|WP_045323125.1|4537217_4537931_-|L,D-transpeptidase-family-protein	gnl|CDD|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	1.08656e-19
NZ_CP018870.1|WP_030027202.1|4533684_4534275_+|Uma2-family-endonuclease	gnl|CDD|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	1.45435e-24
NZ_CP018870.1|WP_075970885.1|4531799_4532198_+|cytidine-deaminase	gnl|CDD|180142	PRK05578, PRK05578, cytidine deaminase; Validated.	1.63879e-72
NZ_CP018870.1|WP_030027203.1|4534573_4535584_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|236196	PRK08241, PRK08241, RNA polymerase subunit sigma-70.	7.6292e-173
NZ_CP018870.1|WP_030027616.1|4548201_4549638_+|aldehyde-dehydrogenase-family-protein	gnl|CDD|143429	cd07111, ALDH_F16, Aldehyde dehydrogenase family 16A1-like. Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.	0
NZ_CP018870.1|WP_075970887.1|4538020_4539316_-|MFS-transporter	gnl|CDD|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.54304e-62
NZ_CP018870.1|WP_075972166.1|4535791_4537141_+|MFS-transporter	gnl|CDD|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.90386e-26
NZ_CP018870.1|WP_075970888.1|4546315_4546975_-|PH-domain-containing-protein	gnl|CDD|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	0.00130591
NZ_CP018870.1|WP_030027201.1|4532310_4533588_+|thymidine-phosphorylase	gnl|CDD|180276	PRK05820, deoA, thymidine phosphorylase; Reviewed.	0
NZ_CP018870.1|WP_030027608.1|4542983_4544132_+|adenosine-deaminase	gnl|CDD|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	5.70163e-158
NZ_CP018870.1|WP_078849136.1|4534318_4534687_+|STAS-domain-containing-protein	gnl|CDD|379202	pfam13466, STAS_2, STAS domain. The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.	0.000187111
NZ_CP018870.1|WP_075970884.1|4530540_4531803_+|ABC-transporter-permease	gnl|CDD|224005	COG1079, COG1079, Uncharacterized ABC-type transport system, permease component [General function prediction only].	2.59519e-81

Protein sequences

>NZ_CP018870.1|WP_075970887.1|4538020_4539316_-|MFS-transporter
MPPVHTGAPAIPGASTASSPAPATAPEPLSPGRPGYRRMSLALFAAGLAAFTLLYATQALLPAISADLGVTAGQASWTVSAATGALALFVLPLSALSERFGRTRMMTWSMAVAVGVALLVPLAPNLEWLVVLRAVQGAAIAGIPASAMAYLAEEVERRALVAAIGLFVAGNSVGGMSGRLVTGWAAQLGGWRAGLAAVAVMALVCAAAFLVLLPRARFFRPASLNPRAVGRTVAGHLRDPLLLRLYGIGALFMTVFGAVYTVIGYRLVDEPFSLGQGVIGSIFLIYLVGTVSSAAAGRLVGRAGRRGALYLAVTTTALGLLLSLSDSLVAVVLGLVLITAGFFAGHAVASAAVSRTAKTGRAQASALYQSAYYLGSSAGGTLGALAYHQAGWAATVGVALLAVLGVVSITLYGTHAARAQRRIPASAAGAR
>NZ_CP018870.1|WP_045323125.1|4537217_4537931_-|L,D-transpeptidase-family-protein
MGTRSARGRAGRRAAVWGGAVALALPLVAVAGGGTAEAASCTPSTGPYQRQVEKFLGRPVDGRQSAADCTAVRAFQSDHGISPAQGYAGPLTWRVMSTMLAQRAAGGTPNRTGDCPVDRGRIACVDLTRQLSWIQDGPVLRYGPVPVRTGKDGTETRTGSKRIYHRSVDHWSTLYDVSMPYAQFFDGGIAFHSTAKSMWNPPGSGGCVNMRPADAKAYWQLLARGEDVYVYGRKPGT
>NZ_CP018870.1|WP_075972166.1|4535791_4537141_+|MFS-transporter
MGKKRRQGEREPGLLAQLRRPPGGRDARIMLLAQLLDRAGTGVWAAACVLYFTFVVGLDAGQVGILLGASGVAGIAGSPLAGHLADRFPVRSLLIGAHLLRLVTLCLLLVVTDFALLLPVVAVTHLGDRAAKTLEMLFATRVAGERRATYQALSRSSANAGYALGAGLAAIGLAVGTRGAYHVLILANALSFLVAAALVWRTREPRGRGLLTAPSPAPAPSPAPAPAATTEDPAPSAGRSPWRDRGYLRFVLLDIPMNLDDSILGIGIPLWLVSHTTAPHELIPAFLVVNTVLVVVLQLRVSAKVQGPRQAAGAVALYGITILLCCVLLAASTGGGVWTASAALLAASVLVTAAELMRSVSSWELAVSLAPREARASYLGVAGMAQSVQKSAGPLLLTGAVMAAGPAGWLALGAAVAGLSLVQRRASLRRLDSLAASPAPAAAPAGAPA
>NZ_CP018870.1|WP_030027203.1|4534573_4535584_-|sigma-70-family-RNA-polymerase-sigma-factor
MSDLATTSTDLDAAMDRYRVELTGYCYRMLGSAFDAEDAVQDTYIRAWRSHEKFEGRSSLRSWLYRIATNVCLDLLNAGNKRARPMDLTAPQHQSSAVLNQRPEVTWLEPVPDGRVLPQTADPAETALAKESVRLAFVAALQHLPPKQRAVLILREVLAWKADEVAQLLDTTVASVNSALQRARATLAGQRLRESEPADPLDAEQAKLLEQYLAAFESYDISRLTTLLHEDAVLSMPPFDLWLQGKEDIAAWHLNQGIGCKGSRLIPTTANGMPAFGQYRPREDGGPGHTPWALQVLEVSEGRIVGLNAFLDTARWFPLFGLPEQLDESYEVQQGA
>NZ_CP018870.1|WP_078849136.1|4534318_4534687_+|STAS-domain-containing-protein
MSSGGAGSHHLVKTTRLALPGPAPTARDAAALCAHLARLYEDGARAVECDARAVTAPGLAHVDALARLRLTARGRPLRVTGAGPALRALLDLVGLVELLGEAEEREPPGRVEEGVEADDPAL
>NZ_CP018870.1|WP_030027202.1|4533684_4534275_+|Uma2-family-endonuclease
MSALTVQQEPQGGDSWEGLVRLWEETDWPEGCRVEIIEGIITVAPPPVNHHNYIAVKVQRALMSVLPEDCEIYQTLNVAVPSRSGLFIPDLVVAPDDVVLEDANYVAGTAAELVVEITSKSNAANDRVAKLHGYAAAGIPFYLLIDPHATGEPAIHLYGEPANGTYRLLWSGKFGETVKLPEPFGVAIDTSAFPRP
>NZ_CP018870.1|WP_030027201.1|4532310_4533588_+|thymidine-phosphorylase
MDVISVIRTKRDRGELSPEQIDWVIDAYTRGVVADEQMSALAMAILLNGMNRTEIARWTAAMIASGERMNFDALSRPTADKHSTGGVGDKITLPLAPLVAACGAAVPQLSGRGLGHTGGTLDKLESIPGWRALLSNEEMMHVLDTTGAVICAAGDGLAPADKKLYALRDVTGTVEAIPLIASSIMSKKIAEGTGSLVLDVKVGSGAFMKNIEDARELARTMVGLGTDSGVKTVALLTDMSTPLGLTAGNALEVRESVEVLAGGGPADVVELTIALAKEMLDAAGIKDADPAKALADGSAMDHWRRMIAAQGGDPDAALPVAREQHVVTAPESGVLTRLDAYGVGVGAWRLGAGRARKEDPVQAGAGIELHAKPGDTVTAGQPLMTLHTDTPEKFDYALAALDGSFDIAAAGTAFAATPIVLDRIA
>NZ_CP018870.1|WP_075970885.1|4531799_4532198_+|cytidine-deaminase
MTAEHAVDWEALRTYAREAMTRAYAPYSGFPVGVAALVDDGRIVTGCNVENASYGLGLCAECGLVSSLQATGGGRLTHFTCVDGKGEILVPCGRCRQLLYEFGGDELLVETPDGILPLAAMLPQAFGPDHLR
>NZ_CP018870.1|WP_075970884.1|4530540_4531803_+|ABC-transporter-permease
MSASTVSTKKAAPAPGGRKKLTLPWILLIIAGGLALVSLVRVISGANDLTSVGQVSGALSLAVPIGLAGLGGLWAERAGVVNIGLEGMMILGTWFGAWAGYQWGPWTGVLVGIVGGAVGGLLHAIITVTFNVNHIVSGVAINILALGFTQYLSNFTFAEAPGGSSKQSPQVEPITKITIPGLSDWMADLQAQHWFFVSDLAGVIGGLITEISLLTIVALLLIPATWWVLWRTSFGLRLRSCGENPIAAESLGVNVYKYKYIAVVVSGALAGLGGVYLCEVASPIYQEGQTGGRGYIGLAAMIFGNWMPGGMALGAGLFGFIDSLKLRGGAENVHAMLLLIAILLVIVCVWQLYKKKYIQAGISAAFAALLFVWYATTDQVPSQFVDAAPYLTTLLVLALSAQRLRMPKADGMPYRKGQGK
>NZ_CP018870.1|WP_030027198.1|4529428_4530544_+|ABC-transporter-permease
MKTFDKDRLMLAIAGPLLALVSAFVLTMIVLAATGINPIEPLRIMVENGGYEDVQILIVNQTGTYYLAALAVAIGFRMNLFNIGVDGQYRLAAMISALVGTAVTLPGPLHILVIVVVAMLTGAFWSGIAGVLKAKRGVSEVVSTIMLNAIATSLIAWLILPKNLGVQVEGSNDLTTGEIAESGWFPAVSMGDSGEIYGFTFIAFALGVVYWFVLNRTRFGFDLRASGASESAAAASGVDSKKMIITAMLISGAVAGLSGMPVLLGETHTYNLGFPVGVGFTGITIALLGRNSPVGMLFAALLMAFIDKASAGLDTEGYAREIGTIMKGLIVIAVVVSYELIRRYGIRRQQQKVGEELAAGHAMKTEKEAAA
>NZ_CP018870.1|WP_030027606.1|4541672_4542041_-|cupin-domain-containing-protein
MAAMDRRNFDEPDETRPFVGGMGRLDLVDTGDGAVGRAVFEPGWKWSEHIKPLAGTDSCQADHTGYVVSGRMKVVTDDGESTEFGPGDYMRVHPGHNAWVVGDEPCVTLDWTGFSDYAKPSG
>NZ_CP018870.1|WP_030027607.1|4542135_4542870_-|hypothetical-protein
MAQHAPPARGARLGRAAGARTGSGPTESPVNGVVLLLPGASRLSPGPMRRLGRALARAGGGHGLVAHAVVHGGESSREEQARWAADEAVRRYGDVPVCLAGYAEGGQAALRAAGHGAVNAVLALAPCLADGADSASLEPVRQLSGRQVLIVHGTNDARSDPEASFRLAERAKKSNRSTCRFEVHSDGHGLREHQAEVVALGVDFVLGAVFSGRYSRPVTDALAAPPPLGLRMPLASGFGRSLRR
>NZ_CP018870.1|WP_030027608.1|4542983_4544132_+|adenosine-deaminase
MTSETPNLPTPDQIRRSPKVLLHDHLDGGLRPGTIIELAREVGYENLPETEADKLGIWFREAADSGSLPRYLETFAHTCAVMQTKAALFRVAAECAEDLAEDGVVYAEIRYAPEQHLEAGLTLEEVVEAVNDGFREGERRAKANGHRIRVGALLTAMRHAARALEIAELANRYRDNGVVGFDIAGAEAGFPPTRHLDAFEYLKRENNHFTIHAGEAFGLPSIWQALQWCGADRLGHGVKIIDDIEVAEDGTVTLGRLASYVRDKRIPLEMCPTSNLQTAAAASYAEHPIGLLRKLHFRLTVNTDNRLMSGTSMSREFEHLVDTFGYTLDDMQWFTVNAMKSAFIPFDERLAMINEVIKPGYAELKSEWLFRQTASTSGSVSA
>NZ_CP018870.1|WP_030027609.1|4544271_4544520_+|hypothetical-protein
MKQSAAKFLGAAAVGAALAAVAAGTASAAVPAIGITDALGTATGALEGVTSQQQMQSEEGQPSDPTAAVTGLLGPVTGALNG
>NZ_CP018870.1|WP_045323119.1|4544636_4545416_+|hypothetical-protein
MRFSVMRMKARATLVALVPALLSAAVGCGSTDAPATGRSPDPKGSASADGAPGAAAAPTDPVGSAQPKAGATRLERSALAQGDLPGYQISAQGKNPNAPDGQPQADKKACQPLADIMGDKPDPAARETVNRGIGSQKQTGLAVSASVSSYSESDAKALISRLRAAVAACGSGFSATVDKQTGSYREIRAADYRTSGDESVSWTTTAAGQGVSAQVHLVVVREGDTVVRLMALNVAAAQQKVQVPQEVTDKQLEKVRKAG
>NZ_CP018870.1|WP_030027611.1|4545421_4545622_-|PspC-domain-containing-protein
MSALVRPRDGRWIGGVCAGLARRFGISANTMRAIFAVSCLLPGPQFLVYIALWVLLPNEKSASTAW
>NZ_CP018870.1|WP_030027613.1|4545660_4546239_-|VanZ-family-protein
MQRIEADGSPAGATAIPLRLRLLAGVLLAAHLVAVGWLTLLPLDVPWAAAGNLTPLEGIRADLALGPLEATRRIGEGLALLAPLGVLVPLVSGRLRLSRLAAWSSLVRTAAAGALVSLSIEMLQSGVPGRVVDVDSVLLNTLGVLIAHAAVVPALRARLRRSHAVYQGDTPRISRVGLGPWTDVLSAVQREY
>NZ_CP018870.1|WP_075970888.1|4546315_4546975_-|PH-domain-containing-protein
MSSQQPTDEPVYDDRVYRSSMGVVSGVLLLALTAWLCGDAVVRGSGNTPWIALAVALCVVPLIVAFTIRPAVFANDDRMRVRNPFRIIELPWAAVDAVRSGYSAEVLAEGSKYQLWSVPVSLRERKKANRQRLRYEGLRDRAERSPDRSPGRSPGERARLQAEPMRASADRIVDELQRMAERGAERPGAQGSVRVQWSYEIIAPAVAGALVLIVLFATR
>NZ_CP018870.1|WP_030027615.1|4547233_4548196_+|deoxyribose-phosphate-aldolase
MPTTLTAFADVTTSDSALRRFLHGLPGVDAVGLEARAASLGTRSIKTTAKAYAIDLAISMIDLTTLEGADTPGKVRALSAKAVNPDPTDRTTPMTAAVCVYPDMVATAKAALNGADVKVASVATAFPAGRAALPVKLADTRDAVAAGADEIDMVIDRGAFLAGRYLETYELIKAVKEACVREDGSAARLKVIFETGELSTYDNIRRASWIGMLAGADFIKTSTGKVGVNATPANTLLMLEAVRDFKAQTGIQIGVKPAGGIRTTKDAIKFLVLVNETAGEDWLSNTWFRFGASSLLNDLLMQRQKLSTGRYSGPDYVTVD
>NZ_CP018870.1|WP_030027616.1|4548201_4549638_+|aldehyde-dehydrogenase-family-protein
MASLFEYAPAPESRSVVDIAPSYGLFIDGEFTDAADGKVFKTVSPSSEEVLSEVAQAGAADVDRAVKAARKAFEKWSALPGSERAKYLFRIARIIQERSRELAVLETLDNGKPIKETRDADLPLVAAHFFYYAGWADKLDHAGYGPNPRPLGVAGQVIPWNFPLLMLAWKIAPALATGNTVVLKPAETTPLSALFFADICRQAGLPKGVVNILTGYGDAGAALVEHPDVNKVAFTGSTAVGKAIARQIAGTDKKVTLELGGKGANIVFDDAPVDQAVEGIVNGIFFNQGQVCCAGSRLLVQESIHDELLDSLKRRLSTLRLGDPLDKNTDIGAINSAEQLARITALADTGEAEGAERWSPACELPSAGYWFAPTLFTNVTQAHTVARDEIFGPVLSVLTFRTPDEAVAKANNSQYGLSAGIWTEKGSRILAVANKLRAGVVWANTFNKFDPTSPFGGYKESGFGREGGRHGLEAYLDV

Crispr_ID: NZ_CP018870_16

• CRISPR_ID: NZ_CP018870_16
• CRISPR_location: 4630404-4630568
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP018870_16

Consensus_repeat	Method
CTGGCGGCCTATGCCCAACCCATGAGACTCGCGGACGC	CRISPRCasFinder

spacers of NZ_CP018870_16

>16.1|4630442|25|NZ_CP018870|CRISPRCasFinder
GTGATGGATAGGCGCACCGCGCTCG
>16.2|4630505|26|NZ_CP018870|CRISPRCasFinder
CGCCTCGCAGAAGCGCGTAGCGATCG

CRISPR arrays and Neighbor proteins around NZ_CP018870_16

CRISPR arrays

The CRISPR arrays of NZ_CP018870_16

>merge|NZ_CP018870|16|4630404-4630568|CRISPRCasFinder
CTGGCGGCCTATGCCCAACCCATGAGACTCGCGGACGCGTGATGGATAGGCGCACCGCGCTCGCTGGCGGCCTATGCCCAACCCAAGAGACTCGCGGACGCCGCCTCGCAGAAGCGCGTAGCGATCGATGGCGGCCTATGTCCAGCCCATGGGGCTCGCAGGCGC

>NZ_CP018870|16|15|4630404-4630568|CRISPRCasFinder
CTGGCGGCCTATGCCCAACCCATGAGACTCGCGGACGC	GTGATGGATAGGCGCACCGCGCTCG
CTGGCGGCCTATGCCCAACCCAAGAGACTCGCGGACGC	CGCCTCGCAGAAGCGCGTAGCGATCG
ATGGCGGCCTATGTCCAGCCCATGGGGCTCGCAGGCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_075970917.1|4623282_4625109_+|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl|CDD|235256
NZ_CP018870.1|WP_030665709.1|4622331_4622967_-|hemolysin-III-family-protein	unknown	unknown	gnl|CDD|367292
NZ_CP018870.1|WP_030033181.1|4625891_4626530_-|RDD-family-protein	unknown	unknown	gnl|CDD|377640
NZ_CP018870.1|WP_079273467.1|4615248_4618575_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
NZ_CP018870.1|WP_158880266.1|4631597_4631825_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030032561.1|4627258_4628470_-|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl|CDD|181738
NZ_CP018870.1|WP_045323790.1|4635210_4636560_+|serine-protease	unknown	unknown	gnl|CDD|213177
NZ_CP018870.1|WP_075970919.1|4633449_4634469_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NZ_CP018870.1|WP_051873427.1|4628799_4629033_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075970915.1|4618837_4620145_+|recombinase-family-protein	unknown	unknown	gnl|CDD|214861
NZ_CP018870.1|WP_045324179.1|4626760_4627153_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075970920.1|4637740_4639321_-|D-aminoacylase	unknown	unknown	gnl|CDD|238622
NZ_CP018870.1|WP_045324398.1|4632879_4633338_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|281995
NZ_CP018870.1|WP_075970922.1|4640788_4641541_+|IclR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224332
NZ_CP018870.1|WP_107484920.1|4620174_4622256_+|thioredoxin-domain-containing-protein	unknown	unknown	gnl|CDD|224250
NZ_CP018870.1|WP_075970918.1|4631056_4631533_+|macro-domain-containing-protein	unknown	unknown	gnl|CDD|394873
NZ_CP018870.1|WP_159393541.1|4625401_4625842_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_045324399.1|4631858_4632827_+|acetyltransferase	unknown	unknown	gnl|CDD|366312
NZ_CP018870.1|WP_030034983.1|4634846_4635032_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075970921.1|4639335_4640628_-|amino-acid-deaminase	unknown	unknown	gnl|CDD|143492

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_075970917.1|4623282_4625109_+|phosphoenolpyruvate-carboxykinase-(GTP)	gnl|CDD|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NZ_CP018870.1|WP_030665709.1|4622331_4622967_-|hemolysin-III-family-protein	gnl|CDD|367292	pfam03006, HlyIII, Haemolysin-III related. Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.	1.93292e-45
NZ_CP018870.1|WP_030033181.1|4625891_4626530_-|RDD-family-protein	gnl|CDD|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	3.85338e-19
NZ_CP018870.1|WP_079273467.1|4615248_4618575_-|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.53682e-06
NZ_CP018870.1|WP_030032561.1|4627258_4628470_-|pyridoxal-phosphate-dependent-aminotransferase	gnl|CDD|181738	PRK09265, PRK09265, aminotransferase AlaT; Validated.	0
NZ_CP018870.1|WP_045323790.1|4635210_4636560_+|serine-protease	gnl|CDD|213177	cd12214, ChiA1_BD, chitin-binding domain of Chi A1-like proteins. This group contains proteins related to the chitin binding domain of chitinase A1 (ChiA1) of Bacillus circulans WL-12. Glycosidase ChiA1 hydrolyzes chitin and is comprised of several domains: the C-terminal chitin binding domain, an N-terminal and catalytic domain, and 2 fibronectin type III-like domains. Chitinases function in invertebrates in the degradation of old exoskeletons, in fungi to utilize chitin in cell walls, and in bacteria which use chitin as an energy source. Bacillus circulans WL-12 ChiA1 facilitates invasion of fungal cell walls. The ChiAi chitin binding domain is required for the specific recognition of insoluble chitin. although topologically and structurally related, ChiA1 lacks the characteristic aromatic residues of Erwinia chrysanthemi endoglucanase Z (CBD(EGZ)).	4.42579e-16
NZ_CP018870.1|WP_075970919.1|4633449_4634469_+|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.50203e-26
NZ_CP018870.1|WP_075970915.1|4618837_4620145_+|recombinase-family-protein	gnl|CDD|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	2.36211e-17
NZ_CP018870.1|WP_075970920.1|4637740_4639321_-|D-aminoacylase	gnl|CDD|238622	cd01297, D-aminoacylase, D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics.	1.19478e-102
NZ_CP018870.1|WP_045324398.1|4632879_4633338_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl|CDD|281995	pfam04075, F420H2_quin_red, F420H(2)-dependent quinone reductase. This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.	1.43444e-32
NZ_CP018870.1|WP_075970922.1|4640788_4641541_+|IclR-family-transcriptional-regulator	gnl|CDD|224332	COG1414, IclR, Transcriptional regulator [Transcription].	3.0985e-72
NZ_CP018870.1|WP_107484920.1|4620174_4622256_+|thioredoxin-domain-containing-protein	gnl|CDD|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP018870.1|WP_075970918.1|4631056_4631533_+|macro-domain-containing-protein	gnl|CDD|394873	cd02901, Macro_Poa1p-like, macrodomain, Poa1p-like family. Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. Members of this family show similarity to the yeast protein Poa1p, reported to be a phosphatase specific for Appr-1"-p, a tRNA splicing metabolite. Poa1p may play a role in tRNA splicing regulation.	1.35528e-31
NZ_CP018870.1|WP_045324399.1|4631858_4632827_+|acetyltransferase	gnl|CDD|366312	pfam00797, Acetyltransf_2, N-acetyltransferase. Arylamine N-acetyltransferase (NAT) is a cytosolic enzyme of approximately 30kDa. It facilitates the transfer of an acetyl group from Acetyl Coenzyme A on to a wide range of arylamine, N-hydroxyarylamines and hydrazines. Acetylation of these compounds generally results in inactivation. NAT is found in many species from Mycobacteria (M. tuberculosis, M. smegmatis etc) to man. It was the first enzyme to be observed to have polymorphic activity amongst human individuals. NAT is responsible for the inactivation of Isoniazid (a drug used to treat Tuberculosis) in humans. The NAT protein has also been shown to be involved in the breakdown of folic acid.	3.75842e-54
NZ_CP018870.1|WP_075970921.1|4639335_4640628_-|amino-acid-deaminase	gnl|CDD|143492	cd06818, PLPDE_III_cryptic_DSD, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase. This subfamily is composed of Burkholderia cepacia cryptic D-serine dehydratase (cryptic DSD), which is also called D-serine deaminase, and similar bacterial proteins. Members of this subfamily are fold type III PLP-dependent enzymes with similarity to bacterial alanine racemase (AR), which contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. AR exists as dimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Based on similarity, it is possible cryptic DSDs may also form dimers. Cryptic DSDs are distinct from the ubiquitous bacterial DSDs coded by the dsdA gene, mammalian L-serine dehydratases (LSD) and mammalian serine racemase (SerRac), which are fold type II PLP-dependent enzymes. At present, the enzymatic and biochemical properties of cryptic DSDs are still poorly understood. Typically, DSDs catalyze the dehydration of D-serine to aminoacrylate, which is rapidly hydrolyzed to pyruvate and ammonia.	2.31751e-156

Protein sequences

>NZ_CP018870.1|WP_051873427.1|4628799_4629033_+|hypothetical-protein
MEFVVGDMAITTVGTDGDDRAIEFLVRPEGTLEEGHFAIFREHGRGWEDARLTIDPAAASVPVAAIEWAVEFAREYL
>NZ_CP018870.1|WP_030032561.1|4627258_4628470_-|pyridoxal-phosphate-dependent-aminotransferase
MQVIQSTKLANVCYEIRGPVLEEAMRLEAAGHRILKLNTGNPAAFGFECPPEILEDMLRNLGSAHGYGDAKGLLSARRAVMQHYQTKGIDLDVEDIYLGNGVSELIQMSMQALLDDGDEVLVPAPDYPLWTASVSLAGGTAVHYRCDEQSDWMPDLADIERKVTDRTKALVIINPNNPTGAVYDEEMLRGLTDIARRHNLVVCSDEIYDRILYDGAKHFNTAAIAPDVLTLTFNGLSKNYRVAGYRAGWMAVCGPKGHAADYIEGLTILANMRLCANMPSQHAVATALGGRQSIEDLVLPGGRILEQRNVAHDLLTQIPGVTCVKPKGALYAFPKLDPAVYKIKDDRQMVLDLLRAEKIMVVHGTGFNWPEPDHFRIVTLPNAKDLADAVTRIGNFLDGYSQA
>NZ_CP018870.1|WP_045324179.1|4626760_4627153_-|hypothetical-protein
MYEPIRTKPVVHRMGGTTVDYPHSSRGEALDIQLAGHLAALLAVTDELGLDEAAETIAAQVARLRGAQPARAPQAPVGDAAALHRRAHDLAARALLVAASRADTTVAILAAERMDAHAAALESLDLAGAL
>NZ_CP018870.1|WP_030033181.1|4625891_4626530_-|RDD-family-protein
MSFGDPNNPYGQQPPQGQPGYGQQAPQGVPPQYGYPQQPAPGAAPQYGYPQTPPPANYGAYPPPGMPGMPGGMPPLAHWGLRFGAYLLDVLIIAGPMYALIGLGAAFSGDETGDSIAGVFSLIGMLYAFGMGFFQLYKEGTTGQTQGKKIVGISLHREADGATLGFGMAFVRKLAHFLDSMACYLGWLWPLWDAKKQTFADKVCSTVVVKVK
>NZ_CP018870.1|WP_159393541.1|4625401_4625842_+|hypothetical-protein
MSALKWQGWLVGLVAIAGLLVFAPLGLYVWASGGGQHEAPPRAAVEDVRVTGCRVDPASRRVAAAVEATGRAEGVGAYVVTVEFRDRAEADPGRRAAQALVRIPGVAPGATEYGEAVGPVWPVATVPWCGVAGAEFTPATPAPGVP
>NZ_CP018870.1|WP_075970917.1|4623282_4625109_+|phosphoenolpyruvate-carboxykinase-(GTP)
MARDNAAPTVPTNHQELISWVDEIAALTQPDRVVWCDGSESEYERLCEELVAKGTFKKLDETKRPNSYYAASDPSDVARVEDRTFICSEKEEDAGPTNHWKAPSEMKEIFAGEKGVFCGSMKGRTMYVVPFCMGPLGSELSAIGVEITDSAYVAVAMRTMTRMGKPVLDELGTDGFFVKAVHTLGAPLAEGEADVPWPCNTTKYISHFPETREIWSYGSGYGGNALLGKKCYALRIASVMARDEGWLAEHMLILKLTPPAGEGETKYVAAAFPSACGKTNLAMLEPTIPGWTVETIGDDIAWMRFGEDGRLYAINPEAGFFGVAPGTGEHTNANAMKTMYANTVFTNVALTDDGDVWWEGMTEDAPAHLVDWKGNDWTPESETPAAHPNARFAVPASQCPTIAPEWEDPKGVPISAILFGGRRASAVPLVTESFDWNHGVFIGSNIASEKTAAAEGKVGELRRDPFAMLPFCGYNMGDYMAHWVKVGASADAAKLPKIYYVNWFRKNDAGKFVWPGFGENSRVLKWIVGRLDGTAEGVQTPIGILPTKDSLDLDGLDIADEDLDFLLTVDKEVWREEAALVPEHLNTYGDHTPKELWEQYHALVERLG
>NZ_CP018870.1|WP_030665709.1|4622331_4622967_-|hemolysin-III-family-protein
MEAKPLLRGWLHLGMFPAVIVAGLALMAFTDSTRARVACGIYILTACLLFGVSAVYHRGTWGPRGEAILRRLDHANIFLIIAGTYTPLTVLLLPPSTGRTLLWAVWIAAAAGIAFRVFWVGAPRWLYTPCYIAMGWAAVFFLPDFMRTGGIAVLVLVIVGGLLYSAGGVIYGMKRPNPSPRFFGFHEVFHSLTLAAFVAHYVGISLAAYQH
>NZ_CP018870.1|WP_107484920.1|4620174_4622256_+|thioredoxin-domain-containing-protein
MRQDGAMPNHLVNETSPYLLQHADNPVDWWPWSPEAFAEARERGVPVHLSVGYSSCHWCHVLAIESFEDELTAAYMNEHFVNIKVDREERPDVDAVYMEAVQAATGQGGWPMTVFLTADAEPFYFGTYFPPEPRHGMPSFMQVLEGVRAAWVGRPEEVADVARKIAQDLAGRQLDYGKAGTPGPEELAQALLGLTREYDATRGGFGGAPKFPPSMVLEFLLRHHARTGSEGALQMVTDTCEAMARGGIYDQLGGGFARYSVDREWVVPHFEKMLYDNALLCRVYAHLWRATGSELARRVALETADFMVRELRTAEGGFASALDADSEDPLTGKHVEGAYYAWTPAQLREVLGEDDGALAAGYFGVTEEGTFEHGTSVLQLPQDGPAVDAERIAGIRARLLAARVERPAPGRDDKVVAAWNGLAIAALAECGAYFERPDLVERATEAADLLVRVHFDAAAGRARLARTSKDGHVGSNAGVLEDYGDVAEGFLALASVTGEGVWLEFAGFLTDLVLDRFTAEDGSLYDTAHDAEKLIRRPQDPTDTAAPSGWTAAAGALLSYAAHTGSEAHRTAAERALGVVHALGPRVPRFIGHGLAVAEALLDGPREVAVVGHPEDPALAALHRAALLGTAPGAVVAVGRPQSAEDGEGEFPLLAGRTLVGGLPAAYVCRHFVCARPTTDPAELSEQLGAVRP
>NZ_CP018870.1|WP_075970915.1|4618837_4620145_+|recombinase-family-protein
MAQIPVASYARTSQDTPQRDARGVRHQHRINERTAREHGCVVVATYTDNARNATKDDRERPAFDHLLADLHRGHAFAAGPLQGVVAVADDRLYRRPEDFIRFMAALTSAPGRVYVARDGLRDPYTKAGLLQGAACLQGAVSEGEMRSRRVQDWHWSRAMDGLPHSGPRPFGWLADRRTLHPVESALVRKAIEDRVGGASMGQVAREWEALGITGTRGGRPNAMTATQIITAPRVCGFRANRGELLIDPETGTPLVGMWEAIVTPEQWTEVCATFSAGSLYTHRGSLSPRLTEGKAGPKYLAAGFVRCGAPLGGGATCGQLMGGRKVASRKSPYNYICASGRGCGRCAISGPLVEDAIDKLLFPADEQGRVRLPTSMRLRWQTGEMGFEEKRKVIASVFAHFVIRPGRKGCGTWDHSRVVPTWKWADRLMSAEPAG
>NZ_CP018870.1|WP_079273467.1|4615248_4618575_-|tetratricopeptide-repeat-protein
MRDSHRGEAERLLERAVDEAVRRGVGSADAAGGAGVPPVDGAVLLSRGREALDALAASAAPEYEAYVRALDEAAAGEQSLGEAFRRGDTSTAVLVTAVAAAAAVGADLSLGVAAGTALTAGAVVGIAGAVATVVRVTASHVPAANRRAGELGRPGGAEQLRLQWLSALEVRGIRPFLEQQRAVAVAARVPRPVAVSPVRAPGGLRGVDRSAEARRRSALEQSFGQLPDVAGRFVGRRSELTRIAQWVQAARASTETRPVVVVLHGEPGVGRTALALRAAHALRDQFRGACVVDMRGGSPGREVGEAGDAGEAGEAPLSTREALLHLMNRLGAPREQLLFREGASAEQQVRRLGELYHQHLRGLPVTVLLDDAVDAAQVRVLVPERSESLVLVTAREPLELPGDVAAWVHQLPVGRLAGDEAAELVRAVAPEAAAAGGAAAEGAAVGVASVVELGGGLPLALRMLAPLVGGGVAAPAGDGSGGGGVHPVEAALRAADARLAEPARLLLRRLPLAGRASLGGSAAAALAGVSEQVALRTLEELWEAGLIERVRGQRFRMHDVVRAYAAARLAADEDRAEAVAAHERLIRDYAQLADAVIRMVDGKMSTRANQFGGHGFVSLDAALRWLDDESSFITAALRHSEGVDQQAVLDLLGALCDFCLLRGDLYRLGEIDELTQAVAAGRQGQAGSQGRLVRSVRWRTGIAARQLGELDRARTTLTSVVDQYMEAHQEAGAAMALVSLGITLHHQGNLPEAAVRIREALVLQEPAELAGDRAWGLHALAAVERDLAHLAEAARLLETSLALHRESESVHGEAWAHFQLGQVYLRFGEVGQAEKELDLALQLYGRTRDERGEAWALTQLGRARVVDGDPGAAVERLREALSRHREAEDARGEAWTQYYLGQALEVGGERDRAVRELERARTMFSRMRDVYGLAHARHHSGRVTRDQRAAQTGNLKNSGFARQLLVDARADFQRIGLAHGEAWTCLELAVVDAGNGRLSQALGLCEEAVRLFISYGDRRGEDWARFLRCTLLPYVGLAGPGVPEEARAELARLVEAPHPARDGRLVDCLETYGVILGRGVDPAEGWQAWRLGLVPDLHAREVMGVPRS
>NZ_CP018870.1|WP_075970918.1|4631056_4631533_+|macro-domain-containing-protein
MKSLSIIAGDATSPQAAGPKVVAHVCNDLGGWGKGFVLAVSKRWREPEIAYRAWHRGRSGNDFGLGAVQMVRVKPDLWVANMVAQRGIRTGSAGPPIRYDALGRCLVALGEHAVELGASVHMPRIGCGLAGGVWPRVEPLITGALCERGVAVTVYDRG
>NZ_CP018870.1|WP_158880266.1|4631597_4631825_+|hypothetical-protein
MTLDDLYTSIVADEIESAAEPERLPLLSRAEADLVLAVLDVVAGGSVDDEVRSIARALRSRLGPRLCTEGPRIPA
>NZ_CP018870.1|WP_045324399.1|4631858_4632827_+|acetyltransferase
MTTKPADTPVPVPGPVSLPAVPSPTDHRPDRWSGEVLDLDAYLARIGYDGPREPTLAVLRDLQRAHTTGIPFENVHAVLGRELPLDLPSVEARLVRDRRGGYCFEHVLLFAAAVERLGFHVTGLIGRVSLGAPKVLPATHGLLAVTARDDDRVWLCDVGFGAGPFGPIELADGAHIAYEGWHHRLERRPGAHGIDQWWLYQTAPGPAGPDDTPGRVPTPWIDRHTFTLTAQYPIDYVVGSHFVGTNARSPFVRRLFAQRMTPAAHHSLDGLTLVTTLPDGTKTTEEIAPEALDGTLRTVFGIALTEEELSGIAARRQAADPV
>NZ_CP018870.1|WP_045324398.1|4632879_4633338_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MHTLAVDWDHPTDPRPGARLDHVRAYVSTAGADGHLWHGVPTLLLTTLDRATGTTVRVPLVYGEDAGRYLVVASADGAPDHPRWYRNLTAHPEVRLQVGAATFTATAHTATATEREVYWEMMTALWPPFEDDQAAARPREIPLVILERHPDR
>NZ_CP018870.1|WP_075970919.1|4633449_4634469_+|LysR-family-transcriptional-regulator
MDLELRHLKIVRAVADAGSLTRAATVLGLAQPALSAQLKRVERALGGSLFVRGREGVRATALGELVLERARVLLPAVCELQEEAQRFARQGERGYRLGGTHGPLLGGLVDRLAEEEPGVAVTTYTSWSEREIAGSVAEGRLDFALVGVCGESAPPEPGRLAWMEVARDPVHVMLAEDHPLALGRAATDEVELAELAAEAWTDVPGDGCFGDCFAAACVRAGFTPACVYETDTASCVHLVQVGRAVGLCRATFPATPGVVTRPLAGTPLVWRHLLGWHPAGRVAARAVGVLGHARAAHAEALGRAAAGGSALRAAPGSAPGPAPDSASAALRSAVPWPAA
>NZ_CP018870.1|WP_030034983.1|4634846_4635032_-|hypothetical-protein
MVSEPDEQPTRSDRLFTGGERPYDPEDLVMATGHDPTPERVEKARKLIEKEGPQVIERYLP
>NZ_CP018870.1|WP_045323790.1|4635210_4636560_+|serine-protease
MLKRHARAACTALAAAGMLLAGTGGAVADPAPTPAAPSAAATLRTADAPPELLAAMQRDLGLTPTQAKARLAHEAEAGATAARLRDRLGAAFAGAWVDGADAGTLTVATTRAADTAAIRAAGARAKLVPRTLADLDGAKAALDRAAGPATPVRYVDPRSNTLVVEETEAGAAARLLDATGTDAALVTVVRTDEAPRPLYDLRGGDAYYMNGSGRCSVGFPVTKGTVNGFATAGHCGRAGTTTTGFNRVAQGSFQASVFPGSDMAWVAANTSWTSTPYVKGSGGANVQVAGSVLQPVGASVCRSGSTTGWHCGTIQQHNTSVTYPEGTISGVTRTTVCAEPGDSGGSYISGSQAQGVTSGGSGNCSSGGTTFFQPLNPILSAYGLTLKVSGGDPGPGPGEPEPGGTWKAGTVYAAGATVTYGGATYRCIQGHQAQTGWEPPNVPALWQRA
>NZ_CP018870.1|WP_075970920.1|4637740_4639321_-|D-aminoacylase
MDLVLRGARVVDGTGGPSYIADVGVHEGRIAAVGRLSGGRETVDAHGLALAPGFVDMHAHSDLALLRDPDHSAKAAQGVTLEVLGQDGLSYAPVDDRTLDAVRAAIAGWNGPGDDIHFDWRTVGEYLDRLDRGFGGEGVALNAAYLVPQGTVRAHVVGWDDRPATAAELDRMRGLVADGLAQGAVGMSSGLTYTPGMYASRSELTALCRVVARHGGYYCPHHRSYGRGALTAYAEMVDLARDAGCALHLAHATMNFGENEDRAPELLALLDTALDAGADITLDSYPYTPGCTTLVALLPSWANAGGPEAVLARLRDDDQAARIRHALEQEGADGCHGVPVDWSTIEISGVTDPAYAAHVGTRVDGWDTARRLLIGDRLAPTILQHVGHEENVRAIMRHRAHTGGSDGILQGAKPHPRAYGTFPHYLGHYVRELGLLSLEECVAHLSGRPATRLRLPDRGLIRVGHRADLVLFDPDTVAAGATYERPRTPPTGIPYVLIGGRFVMRDGRRTQVLAGRSVRRTGSRTG
>NZ_CP018870.1|WP_075970921.1|4639335_4640628_-|amino-acid-deaminase
MASASDPVKDLAAEPVDHRFKGLPPDAQADGLTVGQLAAQRRGLHTGGFTTPVLTLDADALEHNLTALGTYAARHGLAFAPHGKTCMAPQLFRRQLDHGAWGITVAMPHQARVCRAFGIQTIFLANELVDAPALLWVADELAADPGFRFVCYVDSVRGVELMDAALQGRGATLDVVLELGAGAEGRTGLRTDAECQAVAEAVAASPSLRLAGVAGYEATMPGADADSVRAWLRRLTALAADLDKQGLFTGTGLDEVIVSAGGSEWFDAVAEVFTDIPQLSLPVLPLLRSGAYVSHDHGWYSGLTPFNRVPEEGGLLPAFRLWTQVVSRPTPGQAFVNAGKRDIAYDLGLPEVLAVRGARDGVERAAHGIRVTKLSDQHAWIETDADATGLEVGDWVSLGMAHPCTIFEKWPLIPVVEADGAVTDYVRTFF
>NZ_CP018870.1|WP_075970922.1|4640788_4641541_+|IclR-family-transcriptional-regulator
MSQSVERALGILPLLAKGPAGLGDVADELGVHKSTALRLLRTLSERGFVYRRPDGRYRLGAQLFALAAEALENLDVREVARPHLAELNRATGHTVHLALHQDDEVVYVDKVDSRYPVRMYSRIGRPVPLTVAAVAKLLLADLPEGERRALAHRIEYPRYTARSTPDAEAFLRELDLVREQGWAADLGGHEESINCLGAPVRGPGGRVVAALSLSAPGVVVPAEGLLELLPQVLRTADAISQDCSGVQETE

Crispr_ID: NZ_CP018870_17

• CRISPR_ID: NZ_CP018870_17
• CRISPR_location: 4800576-4800694
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_17

Consensus_repeat	Method
GGCTCGACGGGCGGAGCCATCTGGAAGTCCGGCTC	CRISPRCasFinder

spacers of NZ_CP018870_17

>17.1|4800611|49|NZ_CP018870|CRISPRCasFinder
GGGGGCCGACGCCACGACCCGGCGCGGACGGCGCGCCCGCACGGGAGCC

CRISPR arrays and Neighbor proteins around NZ_CP018870_17

CRISPR arrays

The CRISPR arrays of NZ_CP018870_17

>merge|NZ_CP018870|17|4800576-4800694|CRISPRCasFinder
GGCTCGACGGGCGGAGCCATCTGGAAGTCCGGCTCGGGGGCCGACGCCACGACCCGGCGCGGACGGCGCGCCCGCACGGGAGCCGGCTCGACGAGCGGAGCCATCTGGAAGTCCGGCTC

>NZ_CP018870|17|16|4800576-4800694|CRISPRCasFinder
GGCTCGACGGGCGGAGCCATCTGGAAGTCCGGCTC	GGGGGCCGACGCCACGACCCGGCGCGGACGGCGCGCCCGCACGGGAGCC
GGCTCGACGAGCGGAGCCATCTGGAAGTCCGGCTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_030027059.1|4791045_4792317_-|magnesium-transporter	unknown	unknown	gnl|CDD|225148
NZ_CP018870.1|WP_045322633.1|4797399_4798263_+|PHP-domain-containing-protein	unknown	unknown	gnl|CDD|223686
NZ_CP018870.1|WP_075970973.1|4799281_4800139_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|366166
NZ_CP018870.1|WP_030027065.1|4796669_4797314_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030029459.1|4804055_4804283_-|DUF3107-domain-containing-protein	unknown	unknown	gnl|CDD|378634
NZ_CP018870.1|WP_030029460.1|4804423_4805062_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP018870.1|WP_051873079.1|4792531_4793296_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075970975.1|4805568_4806564_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP018870.1|WP_075970971.1|4793380_4793935_+|hypothetical-protein	unknown	unknown	gnl|CDD|236090
NZ_CP018870.1|WP_045322634.1|4798338_4798944_+|MarC-family-protein	unknown	unknown	gnl|CDD|225006
NZ_CP018870.1|WP_030030076.1|4812146_4812902_+|hypothetical-protein	unknown	unknown	gnl|CDD|371915
NZ_CP018870.1|WP_075970972.1|4793985_4794501_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030029457.1|4802746_4803505_+|hypothetical-protein	unknown	unknown	gnl|CDD|205967
NZ_CP018870.1|WP_030031688.1|4808449_4810072_+|DUF3492-domain-containing-protein	unknown	unknown	gnl|CDD|340841
NZ_CP018870.1|WP_075970976.1|4811145_4812159_+|NAD-dependent-epimerase/dehydratase	unknown	unknown	gnl|CDD|366597
NZ_CP018870.1|WP_079273263.1|4806570_4808154_+|DUF3152-domain-containing-protein	unknown	unknown	gnl|CDD|371483
NZ_CP018870.1|WP_037662569.1|4803630_4803930_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030027064.1|4796024_4796609_+|suppressor-of-fused-domain-protein	unknown	unknown	gnl|CDD|377450
NZ_CP018870.1|WP_045322637.1|4805211_4805427_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030027063.1|4794532_4795648_-|magnesium-and-cobalt-transport-protein-CorA	unknown	unknown	gnl|CDD|213364

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_030027059.1|4791045_4792317_-|magnesium-transporter	gnl|CDD|225148	COG2239, MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism].	8.56185e-48
NZ_CP018870.1|WP_045322633.1|4797399_4798263_+|PHP-domain-containing-protein	gnl|CDD|223686	COG0613, COG0613, Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only].	1.68526e-44
NZ_CP018870.1|WP_075970973.1|4799281_4800139_-|alpha/beta-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	2.20239e-25
NZ_CP018870.1|WP_030029459.1|4804055_4804283_-|DUF3107-domain-containing-protein	gnl|CDD|378634	pfam11305, DUF3107, Protein of unknown function (DUF3107). Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.	1.39099e-36
NZ_CP018870.1|WP_030029460.1|4804423_4805062_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.6285e-14
NZ_CP018870.1|WP_075970975.1|4805568_4806564_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.99764e-26
NZ_CP018870.1|WP_075970971.1|4793380_4793935_+|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.96906e-08
NZ_CP018870.1|WP_045322634.1|4798338_4798944_+|MarC-family-protein	gnl|CDD|225006	COG2095, MarC, Multiple antibiotic transporter [Intracellular trafficking and secretion].	1.6156e-43
NZ_CP018870.1|WP_030030076.1|4812146_4812902_+|hypothetical-protein	gnl|CDD|371915	pfam12138, Spherulin4, Spherulation-specific family 4. This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 250 and 398 amino acids in length. There is a conserved NPG sequence motif and there are two completely conserved G residues that may be functionally important. Starvation will often induce spherulation - the production of spores - and this process may involve DNA-methylation. Changes in the methylation of spherulin4 are associated with the formation of spherules, but these changes are probably transient. Methylation of the gene accompanies its transcriptional activation, and spherulin4 mRNA is only detectable in late spherulating cultures and mature spherules. It is a spherulation-specific protein.	2.31622e-22
NZ_CP018870.1|WP_030027063.1|4794532_4795648_-|magnesium-and-cobalt-transport-protein-CorA	gnl|CDD|213364	cd12830, MtCorA-like, Mycobacterium tuberculosis CorA-like subfamily. This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.34766e-167
NZ_CP018870.1|WP_030029457.1|4802746_4803505_+|hypothetical-protein	gnl|CDD|205967	pfam13794, MiaE_2, tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like.	7.38682e-89
NZ_CP018870.1|WP_030031688.1|4808449_4810072_+|DUF3492-domain-containing-protein	gnl|CDD|340841	cd03813, GT4-like, glycosyltransferase family 4 proteins. This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.	1.38193e-147
NZ_CP018870.1|WP_075970976.1|4811145_4812159_+|NAD-dependent-epimerase/dehydratase	gnl|CDD|366597	pfam01370, Epimerase, NAD dependent epimerase/dehydratase family. This family of proteins utilize NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions.	2.27333e-40
NZ_CP018870.1|WP_079273263.1|4806570_4808154_+|DUF3152-domain-containing-protein	gnl|CDD|371483	pfam11350, DUF3152, Protein of unknown function (DUF3152). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	4.55121e-57
NZ_CP018870.1|WP_030027064.1|4796024_4796609_+|suppressor-of-fused-domain-protein	gnl|CDD|377450	pfam05076, SUFU, Suppressor of fused protein (SUFU). SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.	2.94104e-26

Protein sequences

>NZ_CP018870.1|WP_075970973.1|4799281_4800139_-|alpha/beta-hydrolase
MSKPPRLTLPSAARAYRLSTDRGAFAVHEAGEPVRGTALLVPGFTGSKEDFIALLEPLAAAGYRVVAVDGRGQYETPGPREESPYGLEELARDLLAQVRALGAGPVHLVGHSLGGLISRAAVLRDPAPFASLTLLSSGPAAIAEEQQARTKLLVAALEAMGDDMPGIWAAMRAHDPEDAARDSPELTDFLRERWLATVPEQLIVTGRALICEPDRVDELSRIALPKLVLSGSVDYAWPVPLLDAMAERLGARRVVVPGTEHSPNAEDPATTAAALASFWDSTTPV
>NZ_CP018870.1|WP_045322634.1|4798338_4798944_+|MarC-family-protein
MFDFAVFGSLFLTLFVIMDPPGITPIFLALTSGRPVKVQRRMAWQAVCVAFGVIAVFGVCGQQILDYLHVSVPALMIAGGLLLLLIALDLLTGKTDEPKQTKDVNVALVPLGMPLLAGPGAIVSVILAVQKADGAAGQVSVWAAIIAMHAVLWVTMRYSLVIIRVIKDGGVVLVTRLAGMMLSAIAVQQIINGVLQVVQGA
>NZ_CP018870.1|WP_045322633.1|4797399_4798263_+|PHP-domain-containing-protein
MRIDLHAHSTASDGTDTPAELVRNAAAAGLDVVALTDHDTVGGYGEALAALPAGLTLVTGAELSCRLDGIGVHMLAYLFDPEEPELARERELVRDDRVPRARTMVGKLQDLGVDVTWEQVARIAGDGSVGRPHIATALVELGVVPTVSDAFTPDWLADGGRAYAEKHELDPFDAVRLVKAAGGVTVFAHPAAVKRGRCVPESAIAALAAAGLDGIEVDHMDHDADTRARLRGLAADLGLLTTGSSDYHGSRKTCRLGEHTTDPEIYGEITRRATGAFPVPGAGGRER
>NZ_CP018870.1|WP_030027065.1|4796669_4797314_+|hypothetical-protein
MRGEPTCPKCGGRVRAPGLFSDSWQCAVHGAVHPLQPVIPPSVEGLGVVVHRARVPVWMPWPLPLGWLFTGVASAGDDRSGGRATVVACSGPGPVGGMGELLLIAEELGVGLGARYAGIDGLDPGPSIDMAGPPHTKVVAAGRPTPLWNVAGAPDDRAVFAGEARGLWLWAIVWPQQSGLLLYDELVLTDLREGGAEVELLPCGALSPRILGPA
>NZ_CP018870.1|WP_030027064.1|4796024_4796609_+|suppressor-of-fused-domain-protein
MAEILALVEARLRTAFGEPDARAAVTFLGTDRIEVLRFAEGDLLRYATLGMSANPMTDPTAVVADPVRGPRAELVLTVRAGLADTDKLLRPLAVMAASPQVEGLVVAPGASLDVGGPLWEGAPFSSVLVAEPGGLVEDLELDEPMDPVRFLPLLPMTANEAAWKRVHGAAALQERWLARGTDLRDPLRSAVALD
>NZ_CP018870.1|WP_030027063.1|4794532_4795648_-|magnesium-and-cobalt-transport-protein-CorA
MSMLPYLRAAVRPSLRKSTPVQPGYDATRDPSASSAVVDCAVYRDGRRVLGPACLTPREAIRRVREDGGFAWIGLHEPTEAEFAGIAATFGLHPLAVEDAVHAHQRPKLERYDDTLFTVFKTIHYVEHAELTPTSEVVETGEVMCFTGPDFVITVRHGGQGSLKGLRHRLQDDPELLSKGPSSVLHSIADHVVDGYIAVAAAMQDDIDEVESEVFAAPAKGRARGGDAGRIYQLKREVLEFKRAVSPLLRPMELLSERPMRLVDPDIQKYFRDVADHLARVHEQVVGFDELLNSILQANLAQATVAQNEDMRKITSWAAIIAVPTMICGVYGMNFDHMPELRWEYGYPMVMATIFGACFTIHRALRRNGWL
>NZ_CP018870.1|WP_075970972.1|4793985_4794501_-|hypothetical-protein
MTLSTLDLALVEEATKKSGLIWVRGAGADRALWHAWVDGAAHVLGDGPGEQPFPGLADGASAEVTVRSKDKGGRLVAWTATVRELPPRGEQWQAAVAELKGKRLNAPDSEAMTERWARECRLLRLEPESVRSGLPDGSLAAAPLGSPATTRRPVPAALPKLLLKRRKAARG
>NZ_CP018870.1|WP_075970971.1|4793380_4793935_+|hypothetical-protein
MTRKIRKNSVRLCIAAIAASAAAAGGGALGGVPAATATAPFSTGVNSAPFVEDPGGDEGTEPPGEPDAQRVRTAEPTEPPEEPSPEPTEPPEEPSPEPTEPNEPNEPTEPSPEPEEPPTEPPSPDPTEPPEEPPPDPTEPPDPTEPPEEPPPDPDDPPFDIPTKAPPNPYEQQDPPEEDSSGEE
>NZ_CP018870.1|WP_051873079.1|4792531_4793296_+|hypothetical-protein
MRRAAVIGALCAGLAVTGTGCGDDPDEGTNGVGKLSADKIEAKAKAAATEAESVHLSGTLVSGGKSFTLDMRLKSDGGSGEVKSKEDTFQLLRVGEQLYLKASAAFWGQSDSAGKLGDKYVKVPEGDPSYKQFRGFTDMDVLLDGLLGLEGKLAKGSYTKVGSTRAVQVTADEGKGGKLSVSLEGTPYPLLMERAGGAGRVELAEWGKPFQLDPPAQDQTVDYGSQLPTTKGEGGEPAPAPSKGSGQGANPTKP
>NZ_CP018870.1|WP_030027059.1|4791045_4792317_-|magnesium-transporter
MAAGAPRIFVSHLSGVPVFDPNGDQVGRVRDLVAMLRVGGRPPRLLGLVVEVVSRRRVFLPMTRVTGVESGQVITTGVINMRRFEQRPTERLVLGELLDRRVTLVASGEEVTVLDVAIQQLPARRDWEIDRIFVRKGKSGALRRRGEALTVEWSAVTGFSLEEHGQGAENLVATFEQMRPADVANVLHHLTPKRRAEVANALDDDRLADVLEELPEDEQVEILGKLKEERAADVLEAMDPDDAADLLSELPEDDKERLLTLMRPDDAADVRRLLSYEENTAGGLMTTEPIVLRPDATVADALARVRQADLSPALAAQVYVCRPPDETPTGKYLGTVHFQRLLRDPPFTLVSSIVDTDLPPLRPDASLPAVTTHLAAYNMVAVPVVDEGGSLLGAVTVDDVLDHLLPDDWRETDFHSEEALRGQ
>NZ_CP018870.1|WP_030029457.1|4802746_4803505_+|hypothetical-protein
MPTVENASPADDSTPAEATGIASQDWATASASPQYRAAVVDLLGALAYGELAAFERLAEDAKLAPTLDDKAELAAMASAEFHHFEQLRDRLAKIEVEPTAAMQPFAQGVDDFHRQTAPSDWLEGLVKAYVGDSIASDFYREVASHLDTDTRALVLGVLDDTGHGNFAVEKVRAAIEADPRCGGRLALWARRLMGEALSQAQRVVAERDALSTMLVGGVDGMAAGFDLAAVGEMFTRITKAHTKRMAALGLAA
>NZ_CP018870.1|WP_037662569.1|4803630_4803930_-|hypothetical-protein
MLLEVLGSALLGLGLSAAAVRVLAPRLPSRRTVLASGVLGALFGAYLTHFALGPGHYTLMATFVGAVLVSAVVLSLLLRPARGPRRRPHRTPFSLPSRG
>NZ_CP018870.1|WP_030029459.1|4804055_4804283_-|DUF3107-domain-containing-protein
MEVKIGVQHAPREIVLESDLSAEELESIVSAALSGNEPLLSLTDSKGRKVLVPSDRLSYVDLGEPTARKVGFGAL
>NZ_CP018870.1|WP_030029460.1|4804423_4805062_-|TetR/AcrR-family-transcriptional-regulator
MTAIEQTEAARPRGTRLPRRARRNQLLGAAQEVFVAQGYHAAAMDDIAERAGVSKPVLYQHFPGKLDLYLALLDQHCEALLLAVRTALASTTDNKLRVAATMDAYFAYVEDEGGAFRLVFESDLTNEPAVRERVDRVSLQCAEAISDVIAEDTGLSKDESMLLAVGLGGVSQVVARYWLSSESPVARDTAVGLLTSLAWRGIAGFPLHGAES
>NZ_CP018870.1|WP_045322637.1|4805211_4805427_-|hypothetical-protein
MTVDPAEPDTFRERYPESLDPEAPEADVAEQQADLQPGDDDPESGRPAGQAADGDAAEQARVVRLDEDDYR
>NZ_CP018870.1|WP_075970975.1|4805568_4806564_+|alpha/beta-hydrolase
MSSTELPGVRSTPELSSPAGAVRVADGEQLRTAVLPGLELAVRARPPQRAGLPPALFVHGLGGSSQNWSALMEQLADTVDGEAVDLPGFGWSPPPADRDYSVTGFARAVIRHLDAAGRGPVHLFGNSLGGAVSTRVAAVRPDLVRTLTLVSPALPELRVQRSAVPTALLALPGVAALFSRMTQGLTAEQRTRGVTELCYGDPSRVTPEGFRNAVEEMERRMALPYFWDAMTRTSRGIVDAYTLGGQHGLWRQAQRVLAPSLLVYGGRDQLISYRMAHKAAAAFRGSRLLCLPEAGHVAMMEYPEVVAAAFTELLRDTGAGAADRDTEDGRG
>NZ_CP018870.1|WP_079273263.1|4806570_4808154_+|DUF3152-domain-containing-protein
MGRHSRKSGAPAPESAPAQAPAAARQQAQPDPAGYGDPYAYDAFGNVVHESDAFGYGTPGNDSFGNGSYANDSFGNGSYANDPYGSDAYGNGDPFAGWPESTVTHQGYVPQDVPAADTRTGGHPQQYEPGGAWGARSDSGSVYGDWRGVPRPRTEAPAAGAPAAGTAAHAAPPDTGTPPFGTPAAGFPRVTYEEAAPGPLTSTGSHRRVPGPRRPVDPVVESPAPSAEAEVRFEPEREADPESGSGRGRKVRAYTGMAAAAVTTVLAVVVAGQGYLDGDTDEARAGAPAATGKDRSDPAASRSDGRPTPNGGVAAPVAPSAPAAAPELTYEQQMAAQLPLDPKLAGPGTFDTVPGVAKGPGKGKVVRYRVDVEQGLGLDAQLFAEAVHRTLNDDRSWGHGGTKSFERVPGEEADFVITLASPGTTGVWCAKSGLDTVVGNVSCDSAKTERVMINAFRWAQGSETYGPDQMFAYRQMLINHEVGHRLGHGHVNCRTPGALAPVMQQQTKSLNVDGIPCKANPWAFPES
>NZ_CP018870.1|WP_030031688.1|4808449_4810072_+|DUF3492-domain-containing-protein
MRIGLLTEGGYPYATGEARLWCDRLVRGLPQHEFELYALSRSAEQERDRVPLPEHVTRVRTAPLWAPADDGRTYCRRERRRFADCFTELVHGICAGAPDPFAAGLYGLAGLAREQGGLYAALRSESAVRALETACRAPGAPRPVQAARVADLLEFADALEGMLRPLSLDWYEDDAPGDGLGAVDVCHAAAGGVAALPGLLAKRFFGVPLLVTEYGVQLRAHYLAHLGGVGAAEPPRPAVRALLAAFHLRLATEIYARADFLTPGNAHARRWQERCGATRDRLRTVYPGMEADRFTSVGESADRGDPDTLVWVGRVEPAKDIVALLHAFAEVRRAEPRTRLRIFATAADPGYLADCRSLAAQLFPDEAADRVTVGENPVAFEEIGGPEAPSAAEAYGAGRVVVLSSVIEGFPVTLAEAMLCGRATVSTDVGAVCEVIGGTGLVVPPRNPRALAEACLSLLGDAERAERLGAAARARALELFTVEQNVAAFQEIYLRLLAKGSERPDGGVLFARPPEARVPGHWTSPTWAKPVPDPTPEAAV
>NZ_CP018870.1|WP_075970976.1|4811145_4812159_+|NAD-dependent-epimerase/dehydratase
MRVLLIGANGYLGRYVADRLLADPAVQLTALGRGDDADVRFDLATGSPGALTRFLDAVHPGVVINCAGATRGGARELTRHNTVAVATICESLRRSGCGARLVQLGCAAEYGPSQPGSSTAEDAVPRPGGPYGVSKLAATELVLGSGLDAVVLRIFSPVGPGTPAGSPLGRLAEAMRRAMQSGDGELKLSGLGVQRDFVDVRDVARAVHAASLSAAQGVVNIGTGRAVRLRDAAAVLARVAGYAGALHEIDVPHGGAQQAHGHPGRPSAGLTSIGSPRSEATAEQLAATAPQPYPYPDGCGAWQQADVRTARDRLGWRPRINLEESLADIWMEAACRI
>NZ_CP018870.1|WP_030030076.1|4812146_4812902_+|hypothetical-protein
MPHLTTPPGALAAAATGAGRLGLGTPGYAHPLLAPVEWAELTRPGTPLHWAVLNVADGPGGRPDPHCTEAAAKLRAAGGTVLGHLAMRDGARSFGELVCDAHRFRDWYGVDGFYLAGAPAGRAELASVRRVADSLRGLGEDLRIVLGHGTHPCEGYADAADQLVTFSGAWADYRWSQVAEWTAEYPPERFCHLVHGVPRTHLEEAMRIARWQGAGTIWFTDRTAVADRDPWASLPGYWDEIVSRIGTGVLE

Crispr_ID: NZ_CP018870_18

• CRISPR_ID: NZ_CP018870_18
• CRISPR_location: 5662506-5662613
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_18

Consensus_repeat	Method
GGCGCGGGGCCTGGGGCAGAGCCCCAGCAC	CRISPRCasFinder

spacers of NZ_CP018870_18

>18.1|5662536|48|NZ_CP018870|CRISPRCasFinder
CACCGGCCCGGGCCGACGCCCGAACCGCTACCCCCGCGGGAGCGGAAG

CRISPR arrays and Neighbor proteins around NZ_CP018870_18

CRISPR arrays

The CRISPR arrays of NZ_CP018870_18

>merge|NZ_CP018870|18|5662506-5662613|CRISPRCasFinder
GGCGCGGGGCCTGGGGCAGAGCCCCAGCACCACCGGCCCGGGCCGACGCCCGAACCGCTACCCCCGCGGGAGCGGAAGGGCGCGGGGCCTGGGGCAGAGCCCCAGCAC

>NZ_CP018870|18|17|5662506-5662613|CRISPRCasFinder
GGCGCGGGGCCTGGGGCAGAGCCCCAGCAC	CACCGGCCCGGGCCGACGCCCGAACCGCTACCCCCGCGGGAGCGGAAG
GGCGCGGGGCCTGGGGCAGAGCCCCAGCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_045323970.1|5657678_5658479_-|PaaX-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225864
NZ_CP018870.1|WP_030028945.1|5673751_5674462_+|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224715
NZ_CP018870.1|WP_030028942.1|5670717_5671722_+|proline-racemase-family-protein	unknown	unknown	gnl|CDD|368491
NZ_CP018870.1|WP_075972231.1|5658483_5660142_-|AMP-binding-protein	unknown	unknown	gnl|CDD|341268
NZ_CP018870.1|WP_030026977.1|5651482_5651995_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_079273482.1|5671652_5672738_+|proline-racemase	unknown	unknown	gnl|CDD|368491
NZ_CP018870.1|WP_078849012.1|5667919_5668231_+|(2Fe-2S)-binding-protein	unknown	unknown	gnl|CDD|379229
NZ_CP018870.1|WP_030026975.1|5647216_5648764_+|3'-terminal-RNA-ribose-2'-O-methyltransferase-Hen1	unknown	unknown	gnl|CDD|274962
NZ_CP018870.1|WP_030028944.1|5672767_5673673_+|ornithine-cyclodeaminase	unknown	unknown	gnl|CDD|180421
NZ_CP018870.1|WP_075971210.1|5664278_5666663_+|peptidase-M9	unknown	unknown	gnl|CDD|366791
NZ_CP018870.1|WP_075971211.1|5666744_5667920_+|FAD-binding-oxidoreductase	unknown	unknown	gnl|CDD|223737
NZ_CP018870.1|WP_045323971.1|5660288_5661419_+|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|173847
NZ_CP018870.1|WP_078849013.1|5668238_5669708_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|273584
NZ_CP018870.1|WP_045323968.1|5653406_5654426_+|ornithine-carbamoyltransferase	unknown	unknown	gnl|CDD|179366
NZ_CP018870.1|WP_030026978.1|5652041_5653268_+|arginine-deiminase	unknown	unknown	gnl|CDD|234949
NZ_CP018870.1|WP_030033759.1|5661415_5661814_+|RidA-family-protein	unknown	unknown	gnl|CDD|100004
NZ_CP018870.1|WP_075971209.1|5655366_5657622_+|bifunctional-salicylyl-CoA-5-hydroxylase/oxidoreductase	unknown	unknown	gnl|CDD|236203
NZ_CP018870.1|WP_030028941.1|5669782_5670697_+|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl|CDD|188630
NZ_CP018870.1|WP_030026980.1|5654534_5655362_+|enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl|CDD|181329
NZ_CP018870.1|WP_030033051.1|5662724_5664104_-|aminopeptidase-P-family-protein	unknown	unknown	gnl|CDD|238520

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_045323970.1|5657678_5658479_-|PaaX-family-transcriptional-regulator	gnl|CDD|225864	COG3327, PaaX, Phenylacetic acid-responsive transcriptional repressor [Transcription].	3.86092e-38
NZ_CP018870.1|WP_030028945.1|5673751_5674462_+|GntR-family-transcriptional-regulator	gnl|CDD|224715	COG1802, GntR, Transcriptional regulators [Transcription].	9.75496e-41
NZ_CP018870.1|WP_030028942.1|5670717_5671722_+|proline-racemase-family-protein	gnl|CDD|368491	pfam05544, Pro_racemase, Proline racemase. This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Trypanosoma cruzi PA45-A, a protein with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.	9.07039e-158
NZ_CP018870.1|WP_075972231.1|5658483_5660142_-|AMP-binding-protein	gnl|CDD|341268	cd05958, ABCL, 2-aminobenzoate-CoA ligase (ABCL). ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.	0
NZ_CP018870.1|WP_079273482.1|5671652_5672738_+|proline-racemase	gnl|CDD|368491	pfam05544, Pro_racemase, Proline racemase. This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Trypanosoma cruzi PA45-A, a protein with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.	1.31953e-76
NZ_CP018870.1|WP_078849012.1|5667919_5668231_+|(2Fe-2S)-binding-protein	gnl|CDD|379229	pfam13510, Fer2_4, 2Fe-2S iron-sulfur cluster binding domain. The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.	4.88257e-28
NZ_CP018870.1|WP_030026975.1|5647216_5648764_+|3'-terminal-RNA-ribose-2'-O-methyltransferase-Hen1	gnl|CDD|274962	TIGR04074, Methyltransferase_type_12, 3' terminal RNA ribose 2'-O-methyltransferase Hen1. Members of this protein family are bacterial Hen1, a 3' terminal RNA ribose 2'-O-methyltransferase that acts in bacterial RNA repair. All members of the seed alignment belong to a cassette with the RNA repair enzyme polynucleotide kinase-phosphatase (Pnkp). Chemically similar Hen1 in eukaryotes acts instead on small regulatory RNAs. [Transcription, RNA processing, Protein synthesis, tRNA and rRNA base modification].	0
NZ_CP018870.1|WP_030028944.1|5672767_5673673_+|ornithine-cyclodeaminase	gnl|CDD|180421	PRK06141, PRK06141, ornithine cyclodeaminase family protein.	5.99706e-73
NZ_CP018870.1|WP_075971210.1|5664278_5666663_+|peptidase-M9	gnl|CDD|366791	pfam01752, Peptidase_M9, Collagenase. This family of enzymes break down collagens.	8.43196e-55
NZ_CP018870.1|WP_075971211.1|5666744_5667920_+|FAD-binding-oxidoreductase	gnl|CDD|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	1.47649e-55
NZ_CP018870.1|WP_045323971.1|5660288_5661419_+|acyl-CoA-dehydrogenase-family-protein	gnl|CDD|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	2.37069e-98
NZ_CP018870.1|WP_078849013.1|5668238_5669708_+|FAD-dependent-oxidoreductase	gnl|CDD|273584	TIGR01372, sarcosine_oxidase_alpha_subunit, sarcosine oxidase, alpha subunit family, heterotetrameric form. This model describes the alpha subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Mesorhizobium loti and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members are share the same function. The model is designated as subfamily rather than equivalog for this reason.Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines].	1.71838e-29
NZ_CP018870.1|WP_045323968.1|5653406_5654426_+|ornithine-carbamoyltransferase	gnl|CDD|179366	PRK02102, PRK02102, ornithine carbamoyltransferase; Validated.	0
NZ_CP018870.1|WP_030026978.1|5652041_5653268_+|arginine-deiminase	gnl|CDD|234949	PRK01388, PRK01388, arginine deiminase; Provisional.	0
NZ_CP018870.1|WP_030033759.1|5661415_5661814_+|RidA-family-protein	gnl|CDD|100004	cd00448, YjgF_YER057c_UK114_family, YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	8.34327e-21
NZ_CP018870.1|WP_075971209.1|5655366_5657622_+|bifunctional-salicylyl-CoA-5-hydroxylase/oxidoreductase	gnl|CDD|236203	PRK08255, PRK08255, bifunctional salicylyl-CoA 5-hydroxylase/oxidoreductase.	0
NZ_CP018870.1|WP_030028941.1|5669782_5670697_+|dihydrodipicolinate-synthase-family-protein	gnl|CDD|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	2.94888e-86
NZ_CP018870.1|WP_030026980.1|5654534_5655362_+|enoyl-CoA-hydratase-family-protein	gnl|CDD|181329	PRK08258, PRK08258, enoyl-CoA hydratase family protein.	2.54682e-142
NZ_CP018870.1|WP_030033051.1|5662724_5664104_-|aminopeptidase-P-family-protein	gnl|CDD|238520	cd01087, Prolidase, Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.	8.66605e-89

Protein sequences

>NZ_CP018870.1|WP_030033759.1|5661415_5661814_+|RidA-family-protein
MSLERINPAELSPATGFSHAVVATGSRLVFLAGQTALDGAGKVVGETLPEQFETALANLLSALAAAGGAPGDLARVTVYAVDVAAYRLHAAELGRIWRRLAGRDYPAMAVVGVTRLWDEAARVELDGLAVLP
>NZ_CP018870.1|WP_045323971.1|5660288_5661419_+|acyl-CoA-dehydrogenase-family-protein
MTGFALGLDQEEWCGRLRALSEQRLRPLAEKGEPGRVNRPLLAALGELGLLERVFASGALELCLLRESLAYGCTEAETALALQGLGAYPVLRAGTEAQKERWLPGVRAGRTVAAFALSEPGAGSDAAALALAADPDPAGGWRLAGEKCWISNAPEADFYTVFARTGEGPGAKGVTAFLVPADRDGLSGEPLDMLSPHPIGSLRFDGVPVGPEDLLGEPGRGFRVAMDTLNLFRPSVGAFAVGMARAALDATLAHTAGRTAFGGTLSDLQAVAHRVAEMATRTEAARLLVYAAAGAYDRGAADVPGRVAMAKLLATETAQYVVDHAVQLHGAVALRRGHLLEHLYREVRAPRIYEGASEVQRTIIAKELYGALGAGR
>NZ_CP018870.1|WP_075972231.1|5658483_5660142_-|AMP-binding-protein
MDLKPSAHVDTFARDHLPPADAWPELLFDLPELAYPDRLNCGAELLDATIARFGPEGADRPAFRDGAGEVWTYGGLRDRVDRIAHVLTADLGVVPGNRVLLRGPTSPWLAACWLAVMKAGAVAVTVLPQQRAQELATVCAMAQVRHALCHADVLDDLVKAEVPGLRITAYGGGAEDDLLRRAERHDAPFPAVATSADDVALIAFTSGTTGRPKGCMHFHRDLLAVADTFSRHVLRPRPDDVFAGSPPLGFTFGLGGLVVFPLRAGASALLLQDAVPRRLLPALAKHRVTVLFTAPTAYRTMLDALGPYDVGMYDLSALRRCVSAGENLPAATWQAWFERTGLRIVNGIGATELLHIFISAADGDIRPGATGRVVPGWQARVVDRAGRPVPDGEPGLLAVRGPVGCRYLADPRQAEYVQNGWNLTGDTYVRDTEGYFRYVARADDMIVSAGYNIAGPEVEEALLRHPDVVEAAVVGRPDERRGQVVVAYTVVRDGVVLTEDALRTFMRAELAPHKCPRSFVFLPALPRTATGKLQRFRLRDQGVRSDRRDALE
>NZ_CP018870.1|WP_045323970.1|5657678_5658479_-|PaaX-family-transcriptional-regulator
MVEQHTPRSLIVTFYGAYGRSYEGPVPVSALVRLLGAAGVDAPSVRSSVSRLKRRGFLLPARAADGAAAYELSGEARRLLDDGDRRIYGGPRASDEWLVAVFSVPEQERSKRHLLRSRLAGLGFGAVAPGVWIAPSRLAEETAHTLERLRLTPYVELFRGTHLGFAPSAEAVARWWDLTSLAKQHEEFLDLHEPALRALQSGPRPTPEEAYRGYLLALDSWRRLPYADPGLPRELLPADWPGDRAAAVFAELHARLRDLGAEFVAL
>NZ_CP018870.1|WP_075971209.1|5655366_5657622_+|bifunctional-salicylyl-CoA-5-hydroxylase/oxidoreductase
MPHGSALRVAVVGGGPGGLYAAALLARRGHTVEVWERNAPDDTFGFGVVLSDETLGGIERADSVVHAALSREFVRWDDVDVVHRGRLLTSGGHGFAAIGRRRLLEILHERCAGLGVRLRFRTEAPDLTGLRASHDLVVAADGVHSAIRDADAAHYRPTLTPGRCRYIWLAADFALEAFRFEIAETEHGVMQLHAYPYAADASTVIVEMREEVWRAAGLDLCDEEESAARCAKTFGEALRGRPLHGNRSAWTRFHTVVNEHWSHGNVALVGDAAHTAHFSIGSGTKLAVEDVLALAEAVDAADGDVPAALAAYEAARRPAVASTQRAAAASSRWFEEIAGYVDQPARQFAFNLLTRSRRVTHDNLRLRDERFTRAVERDFGCPDDATPPMFTPLTLRGLTLRNRVVVSPMDMYSAEEGVPGDFHLVHLGARALGGAGLVMTEMVCVSEDGRITPGCAGLYTPEQAAAWQRITDFVHTSAPGTALGVQLGHAGRKGSTKVMWEGMDDPLPDGNWPLVAASALPYRPGVSALPRALEPADLDALRSDFAAAAVRAADCGFDLLELHCAHGYLLSGFLSPLTNHRTDAYGGPLRNRLRFPLEVFDAVRAVWPEDRPMTVRLSATDWAPGGTSPEEAVEIAAAFAAHGADAIDVSTGQVVADEAPEYGRSYQTPYADRIRNTLGVPVIAVGAISSWDDVNSLLLAGRADLCALGRPHLHDPHWTLHAAADQSYEGPAAPWPKPYRAGSRKPPTGRG
>NZ_CP018870.1|WP_030026980.1|5654534_5655362_+|enoyl-CoA-hydratase-family-protein
MSPFTGSTPATERWHHLRLTRQDGVATVTFDRPEKINALTFGAYADLRDLLAELSRERSVRALVLGGEGRGFCSGGDVDEIIGATLAMDTAQLLDFNRMTGQVVRAIRECPFPVIAAVHGVAAGAGAVLALAADFRIADPTARFAFLFTRVGLSGGDMGAAYLLPRVVGLGHATRLLMLGEPVHAAEAERIGLLSELTDEGKAHVRAAELAARLAAGPSLAHAQTKALLTAELDMPLAASVELDAATQALLMNGQDYAEFHAAFTGKRPPEWKGR
>NZ_CP018870.1|WP_045323968.1|5653406_5654426_+|ornithine-carbamoyltransferase
MAPDLKGRSFLKELDFSAAEFRGLVELAADLKAAKRAGAEQQHLRGRNIALIFEKTSTRTRCAFEVAAADQGAHTVYLDPAGSQMGHKESVRDTARVLGRMFDGIEYRGDSQESVEALAAHSGVPVFNGLTDDWHPTQMLADVLTMTEHSTKPLHRISFAYLGDARFNMGNSYLVTGALLGMDVRIVAPRSYWPAEHVVAEARRLAADSGARITLTEDVAEGVAQADFVVTDVWVSMGEPKEVWDERIAALAPYAVTMDVLRATGNPDVKFMHCLPAFHDLGTKVAREIHERHGLDSLEVTDEVFESEHSVVFDEAENRLHTIKAVLVATLGRPGPGDA
>NZ_CP018870.1|WP_030026978.1|5652041_5653268_+|arginine-deiminase
MGFHVDSETGRLRRVILHRPDLELKRLTPGNKDALLFDDVLWVRRARQEHDGFADVLRDRGVDVHLFGDLLREVLDVPEARRLVLDRVFDEKEYGPLATDHLRSAFDGLASADLAEALVGGMTKREFLERHAEPVSVRFHALDTDDFLLGPLPNHLFTRDTSAWIYDGVSINAMRWPARQRETVHFEAIYRHHPLFTASGAFHYWSQGQADYPSTIEGGDVLVIGNGAVLIGMSERTTPQAVEMLARGLFAAGSATSIVALDMPKHRAFMHLDTVMTMVDGDTFTQYAGLGMLPSYTIEPGDGGNELKVTDHPAEHMHRAIAAALSLDSIRVLTATQDVHSAQREQWDDGCNVLAVEPGVVVAYERNVTTNTHLRKQGIEVIEIPGSELGRGRGGPRCMSCPVQRDPV
>NZ_CP018870.1|WP_030026977.1|5651482_5651995_+|hypothetical-protein
MKMTARGSIAALLTCMAAAGVATPAVADGVPVGVPLEGVETTTGLDVPRVATAVPLPVVGAPEAPRMHTGEMLPTPLLPAVPIATELGRTLVTSPLPNLAGHPETDGEGSLEAPATTVRTRTPGAVVGSPLTMPDGSNFGLPNLTTPKLGLLAPEVTGAPEALLGVALPR
>NZ_CP018870.1|WP_030026975.1|5647216_5648764_+|3'-terminal-RNA-ribose-2'-O-methyltransferase-Hen1
MFLTITTTGTAENPATDLGFLLHKHPDRVRVESQSHGTAHVFYPEATAERCTAALLLEVDPIALVRRGRSKGKGRGGAPDAALAQYVNDRPYAASSLLAVALSGVFRTALKGTCVLRPELPGRTRPLRIEIPVLPARGGAAMVHRLFDPLGWDTVQAEAVPLDEQFPEWGDSRYVHLVLEGELRLADALRQLYVLLPVLDDAKHYWIAPDEVDKLLRAGDGWLAAHPEHALISSRYLARHKRLTQEAVDRLELVRLAESDGSEVEEIDNAVDETSDTEERPVPLAVQRRDAILAALRAAGAQRVLDLGCGQGQLVQALLGDPAYTEIVGMDVSVRALTVAARRLRLERMGERQRSRVTLFQGSLAYTDKRLAGYDAAVLSEVVEHLDLERLPALEYAVFGSARPRTVLVTTPNVEYNVRWESLPAGHVRHGDHRFEWTREEFRAWAGQVAARFGYTVAYVPVGDDDPEVGPPTQMAVFTQVTGAATETASATPTTETTTTTETTTTDSPKEGEAA
>NZ_CP018870.1|WP_030033051.1|5662724_5664104_-|aminopeptidase-P-family-protein
MTDTPARLNTGSHDRPVSPELSRFMADGWAASPLPDSARVPGHDVTPARRARLSARFPGERLIIPAGELKVRSNDCDHRFRPHSAYAWLTGLTGEDQAGHVLVMEPSGPHAHEAVLHLRPRSPRADGDGEFYRDRRYGEFWVGRRPDLAEAERLTGIRCAHLDALGSPDGRHAGSDAELAAALSELRLVKDAWEVEQLQLAVDHTTAGFEDVVRALPRALAHPRGERWIEGVFGLRARAEGNGTGYETIAASGAHACTLHWIRNDGPLNGQELLLLDAGVETDTLYTADITRTLPLSGRFSPVQRQVYELVLAAQEAGIAALRPGASFGDFHRAGMRVIAEGLADWGVLKNAEGDLHRRYTLCSSGHMLGLDVHDCAKARAETYLDGVLEEGQVLTVEPGLYLQPDDETLPAELRGIGVRIEDDLVITENGARLMSGGLPRTVAGIEEWMAVLLQGARR
>NZ_CP018870.1|WP_075971210.1|5664278_5666663_+|peptidase-M9
MLKHRAVRSSLLASAVAVTLVATAGQGATQAAESAAPAAFAGAQAAAPATAAHGPTGNPFDEVDRFAEAKDNAPAPAPAPGGLKISGQVPGAAPAAAPVQDLEKRGTAAKSAPTAKSVAAGVPCTLDGITNLGPEQFADFLADPAVLADGCLRGLIWTWDARLAPVMSDAHVQAVSRRISALAAAHDGRNSSHLEEMFTYLHAVAYHDFSRDEIDVTDAPTTAAIRKAIDDFGNAARTFDVTPANARTLREALYSAGPGLRQHQLGLTKKVLATMDPAHPATHLDAGWAGAVLAALSNNYLGVYPGNEDTAFHAAVAADPAYRAAFKAFAGYTHLKDSGNAWVVRDALSEYARFGQVDGLRDQVVADLGAMLGPLKAGFGDGSEPWAKVVSWLNFYQACKPYGVCKEDIEKKLFPYTYTYDNGAIKVRTALDRATVDQLYYASKQVKAQYHRVLGTDQPLAGDPNDTLNIVLYASRADYVNYHPILTGYDTNNGGIYIENGATFYTYQRRVPQDSSLTLEELFRHEYTHYLNGRFAVPGFFGQGPWYEGDRTTAMDEGTAEFFDGATRDNGIAVRKSLVKSIISDTAGGGPRMSVEQLLNATYDGDGFRFYSYAGTFFEFLWTEKPSLLREMYTHLRANDVAAYDAWRHRLGADTYLQRDYDRFLDAQIAKVDQLFVPNTTFTPNERLRDSALASVKSSFATATYNTPDCVENGDPGKRRFTCTGRITANLKNWRSDDQNFKDMSETVDYFILDRAGAASNNLADMNCSFSTPEIWSNKVAATSTYSCEGPLRS
>NZ_CP018870.1|WP_075971211.1|5666744_5667920_+|FAD-binding-oxidoreductase
MLKRHSLDAVIVGAGVVGAACAYYAARAGLSVAVVDRGPVAGGTTGAGEGNLLVSDKEAGPELDLALLTTRLWTELAAVLPREVEYEAKGGLVVAPDEATVKALRTFAEGQRAAGVDAVEVPAHALHDLEPHLAPGLAGGFHYPQDAQVQPAQAAARLLAASGAEVHLGEEVVEVLLDRGAVRGVRTPRRELLAPAVVNAAGTWGGHVARLAGTDLPVLPRRGFVLVTEPLPRVVRHKVYAADYIADVASGSAALQSSAVVEGTPAGPVLIGATRERVGFDRSLSTQALRRLASQAAALFPVLAGVRVLRTYHGFRPYLPDHLPAIGPDPRRPGLLHACGHEGAGIGLAPATGLLVAAALTGAEPPLPAHPFRPDRFGSGPAPADTPEEHP
>NZ_CP018870.1|WP_078849012.1|5667919_5668231_+|(2Fe-2S)-binding-protein
MRSPRSLVGGSPEAAYEITFDGRELPAQDGQSIAAVLWAAGILAWRTTREGGAPRGAFCGIGSCYDCLVTVNGRPNQRACLVPARPGDAVTTQEGTGRADLTV
>NZ_CP018870.1|WP_078849013.1|5668238_5669708_+|FAD-dependent-oxidoreductase
MPSSEPADPAPRTPPAPPAEPVDLAVVGAGPAGLAAAVTAAGRGLRVALLDAGDRPGGQFYRHPAPGLGAARPEALHHGWAEFATREAALRAHESAGRITHLPLHHVWTVVPGEGGWTLHAVAGHAPQERAAAVTARAVLIATGAYERQLPFPGWTLPGVVGAGGAQAMLKGGLVLPGKRVVVAGSGPLLLAVAGSLAAAGATVPAVVEAAAYTAYAGRLPTLLRNPAKLVEAAGYGGALARHHVRLLTRHAVTEAHGTGRIEAVTVARLDRDWRPLPGTARRIPCDALAVGHGLVPQLELATGLGCATRPSPDGTVALEVDAEQRTSVPGIWSAGETGGIGGAQLALTEGELAAHSVADALHPGQGAPREARVERLARRRARLRAFAGAMAAAHRPGEGWTGWLRDDAVVCRCEEVPAGRIREAAGDLGARDARTVKLLTRAGMGWCQGRMCGPAVAALAGQEPAADRRPFSCPVPLGHLAELPATDR
>NZ_CP018870.1|WP_030028941.1|5669782_5670697_+|dihydrodipicolinate-synthase-family-protein
MTDAHTPAPRTRPWHGIMVATALPLREDLSVDHDAYAEHVAWLIANGCDGVVPNGSLGEYQTLTDEERARVVRTAVEAAGDGARVMPGVAAYGSAEARRWADQAAEAGAGSVLLLPPNAFRADEETVRAHYAEVARAGLPVVAYNNPIDTKVDLVPSLLARLHADGSIVAVKEFSGDVRRAYEIAELAPGLDLLIGADDVLLELALAGAVGWIAGYPNALPRSCATLYRAAVAGDLDTALPLYKSLHSLLRWDSKTEFVQAIKLSMDLAGRPGGATRPPRFPLTGETEAAVRAATEKALAEGLN
>NZ_CP018870.1|WP_030028942.1|5670717_5671722_+|proline-racemase-family-protein
MRTRHVYHAVDSHTEGMPTRVVTGGVGVIPGATMADKRLHFIEHMDHLRTLLMYEPRGHSAMSGAILQPPTRPDADYGVLYIEVSGLLPMCGHGTIGVATVLVETGMVPVVEPVTTVRLDTPAGLVSVDVRVEDGAATAVTLTNVPSFSVGLDLKADVPGHGTVTYDLAYGGNFYAFVELDALGLPFDRARKDDLLAAGLALMDAINTGPDRPVHPENPSIAGVKHVYLAAPGSDARRSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGLLGLDTDFTNESFIGTEFTGRLVARTTVGGLPAVVPTVTGRAWITGTAQYFLDPSDPFPGGFLL
>NZ_CP018870.1|WP_079273482.1|5671652_5672738_+|proline-racemase
MDHRHRPVLPRPVRPLPRRLPPVTTVRTVDYHTAGEPFRIVDTAAEGMPPVPGDTVAERCATAVGPGGSGTAPRRGALDDVRRMLVQEPRGHAGMYGGFVVPADDDGAHFGVLFWHKDGYSTACGHGTMALGAWAVDSGRVAAPADGDVPVRIDVPSGRVTATVHRGGGRTTGVTFRNVPARVGARKVPVATTLGLAEADIAHAGACYASVRARDLGLEVSRAALPALVRAGQEVRAALATHPATWHPGGPLLSGVYGVILHEELPDTPFGPHQRNVTVFADGQVDRSPCGSGTSTRLALLAEDGRLGPGEDLLSESVTGTVFTGRMLDGGVTEVTGTAYRTGEHAFAVDPYDALGTGFQL
>NZ_CP018870.1|WP_030028944.1|5672767_5673673_+|ornithine-cyclodeaminase
MAALLRPAEAADALAAALRGGLDPEDCPPRSAIAVPGGGELLLMPAASGAYAGVKIAGVAPGNPARGLPRITGSYLLLDGPTLRPVARMDGAALTTLRTPAVSALALRHLAPAGRPLRLVLFGSGPQAYGHLDAVLAERELADVVVVARDGERAERLAAYARTLGPAARTGAPHDVADADLVVCCTTAREPLFDGRLVRPGAVVVAVGSHEPTARETDTALVRRAAVYVESRAAALREAGDLLVPEAEGAIGPGHITGTLADLVAGRLPGAGERGCPQLFKSVGMAWEDLAVAVALYEAAR
>NZ_CP018870.1|WP_030028945.1|5673751_5674462_+|GntR-family-transcriptional-regulator
MGDLKQHSLIKAQERLRDQVGHALRAALIAGELRPGSVYSAPGLAAELGVSATPVREAMLDLAREGLVEPVRNKGFRITEVSERDLDQYTELRTMIEVPTIGRITQTATAGQLEELRPIAEEIVTSAREHNLIGYLEADRRFHLTLLGLSGNERLVETVGDLRKRSRLYGLTGLDEAGKLVSSAEEHLELLDLMISGDAKAAEACMQRHLGHVRSLWAQGRDEPVGRPPGGLGAVR

Crispr_ID: NZ_CP018870_19

• CRISPR_ID: NZ_CP018870_19
• CRISPR_location: 7077105-7077206
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_19

Consensus_repeat	Method
GGCCTTGCCCTTGGCCTGCTCCGC	CRISPRCasFinder

spacers of NZ_CP018870_19

>19.1|7077129|54|NZ_CP018870|CRISPRCasFinder
CTGCCCCTCCGCGGTCATGCGCTCGTTGCCGACGGCGCGACCGACGGTCTCCTT

CRISPR arrays and Neighbor proteins around NZ_CP018870_19

CRISPR arrays

The CRISPR arrays of NZ_CP018870_19

>merge|NZ_CP018870|19|7077105-7077206|CRISPRCasFinder
GGCCTTGCCCTTGGCCTGCTCCGCCTGCCCCTCCGCGGTCATGCGCTCGTTGCCGACGGCGCGACCGACGGTCTCCTTGGCCTTGCCCTTGGCCTGCTCGGC

>NZ_CP018870|19|18|7077105-7077206|CRISPRCasFinder
GGCCTTGCCCTTGGCCTGCTCCGC	CTGCCCCTCCGCGGTCATGCGCTCGTTGCCGACGGCGCGACCGACGGTCTCCTT
GGCCTTGCCCTTGGCCTGCTCGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_075971789.1|7085923_7087075_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|293787
NZ_CP018870.1|WP_075971779.1|7073662_7074316_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_045321565.1|7074438_7074684_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|226181
NZ_CP018870.1|WP_159393600.1|7082617_7082767_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075971783.1|7078528_7078999_+|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|240041
NZ_CP018870.1|WP_075972344.1|7085370_7085880_+|hypothetical-protein	unknown	unknown	gnl|CDD|275056
NZ_CP018870.1|WP_030036337.1|7069261_7069675_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_045321563.1|7076019_7076211_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_045321564.1|7074683_7075169_-|DUF2975-domain-containing-protein	unknown	unknown	gnl|CDD|378586
NZ_CP018870.1|WP_107484877.1|7073042_7073681_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_052680510.1|7076383_7076833_-|PRC-barrel-domain-containing-protein	unknown	unknown	gnl|CDD|368352
NZ_CP018870.1|WP_030036342.1|7070794_7072630_-|CocE/NonD-family-hydrolase	unknown	unknown	gnl|CDD|273375
NZ_CP018870.1|WP_075971787.1|7082873_7083287_-|hypothetical-protein	unknown	unknown	gnl|CDD|376042
NZ_CP018870.1|WP_075971778.1|7070118_7070523_-|VOC-family-protein	unknown	unknown	gnl|CDD|319939
NZ_CP018870.1|WP_159393599.1|7081796_7082129_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075971784.1|7079144_7079459_-|TraR/DksA-family-transcriptional-regulator	unknown	unknown	gnl|CDD|274340
NZ_CP018870.1|WP_075971782.1|7077893_7078409_+|N-acetyltransferase	unknown	unknown	gnl|CDD|225695
NZ_CP018870.1|WP_075971785.1|7080630_7080852_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030036351.1|7075379_7075886_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075971781.1|7077479_7077737_+|hypothetical-protein	unknown	unknown	gnl|CDD|274009

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_075971789.1|7085923_7087075_-|HEAT-repeat-domain-containing-protein	gnl|CDD|293787	sd00044, HEAT, HEAT repeats. The canonical HEAT repeat consists of two helices forming a helical hairpin. HEAT repeats are found in a diverse family of proteins, including the four proteins from which its name is based: Huntingtin, Elongation factor 3, the PR65/A subunit of protein phosphatase 2A (PP2A), and the lipid kinase TOR (target of rapamycin). The HEAT repeat family is related to armadillo (ARM)/beta-catenin-like repeats.	9.40304e-13
NZ_CP018870.1|WP_045321565.1|7074438_7074684_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|226181	COG3655, COG3655, Predicted transcriptional regulator [Transcription].	1.08853e-28
NZ_CP018870.1|WP_030036342.1|7070794_7072630_-|CocE/NonD-family-hydrolase	gnl|CDD|273375	TIGR00976, Hypothetical_protein_Rv1835c/MT1883/Mb1866c., putative hydrolase, CocE/NonD family. This model represents a protein subfamily that includes the cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). This family shows extensive, low-level similarity to a family of xaa-pro dipeptidyl-peptidases, and local similarity by PSI-BLAST to many other hydrolases. [Unknown function, Enzymes of unknown specificity].	4.36202e-19
NZ_CP018870.1|WP_075971782.1|7077893_7078409_+|N-acetyltransferase	gnl|CDD|225695	COG3153, COG3153, Predicted acetyltransferase [General function prediction only].	1.36117e-26
NZ_CP018870.1|WP_045321564.1|7074683_7075169_-|DUF2975-domain-containing-protein	gnl|CDD|378586	pfam11188, DUF2975, Protein of unknown function (DUF2975). This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.	2.17462e-21
NZ_CP018870.1|WP_075971783.1|7078528_7078999_+|NUDIX-domain-containing-protein	gnl|CDD|240041	cd04685, Nudix_Hydrolase_26, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	5.64842e-20
NZ_CP018870.1|WP_052680510.1|7076383_7076833_-|PRC-barrel-domain-containing-protein	gnl|CDD|368352	pfam05239, PRC, PRC-barrel domain. The PRC-barrel is an all beta barrel domain found in photosystem reaction centre subunit H of the purple bacteria and RNA metabolism proteins of the RimM group. PRC-barrels are approximately 80 residues long, and found widely represented in bacteria, archaea and plants. This domain is also present at the carboxyl terminus of the pan-bacterial protein RimM, which is involved in ribosomal maturation and processing of 16S rRNA. A family of small proteins conserved in all known euryarchaea are composed entirely of a single stand-alone copy of the domain.	5.55581e-05
NZ_CP018870.1|WP_075971787.1|7082873_7083287_-|hypothetical-protein	gnl|CDD|376042	pfam18616, CdiI_3, CDI immunity proteins. Contact-dependent growth inhibition (CDI) is a widespread mechanism of bacterial competition. CDI+ bacteria deliver the toxic C-terminal region of contact-dependent inhibition A proteins (CdiA-CT) into neighboring target bacteria and produce CDI immunity proteins (CdiI) which bind CdiA-CT domains and neutralize their toxic activity to protect against self-inhibition. CdiI immunity proteins are also variable and only neutralize their cognate CdiA-CT toxins. Structure analysis of CdiI from Escherichia coli 536 (EC536) shows that is composed of a single domain and that it blocks the interaction with substrate, strongly suggesting that the immunity protein occludes the nuclease active site.	1.12556e-29
NZ_CP018870.1|WP_075971778.1|7070118_7070523_-|VOC-family-protein	gnl|CDD|319939	cd08351, ChaP_like, ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins. ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	2.49849e-66
NZ_CP018870.1|WP_075972344.1|7085370_7085880_+|hypothetical-protein	gnl|CDD|275056	TIGR04211, hypothetical_protein, SH3 domain protein. Members of this protein family have a signal peptide, a strongly conserved SH3 domain, a variable region, and then a C-terminal hydrophobic transmembrane alpha helix region.	0.00275272
NZ_CP018870.1|WP_075971784.1|7079144_7079459_-|TraR/DksA-family-transcriptional-regulator	gnl|CDD|274340	TIGR02890, conserved_hypothetical_protein, regulatory protein, yteA family. Members of this predicted regulatory protein are found only in endospore-forming members of the Firmicutes group of bacteria, and in nearly every such species; Clostridium perfringens seems to be an exception. The member from Bacillus subtilis, the model system for the study of the sporulation program, has been designated both yteA and yzwB. Some (but not all) members of this family show a strong sequence match to Pfam family pfam01258 the C4-type zinc finger protein, DksA/TraR family, but only one of the four key Cys residues is conserved. All members of this protein family share an additional C-terminal domain. Smaller proteins from the proteobacteria with just the N-terminal domain, including DksA and DksA2 are RNA polymerase-binding regulatory proteins even if the Zn-binding site is not conserved. [Unknown function, General].	2.24465e-19
NZ_CP018870.1|WP_075971781.1|7077479_7077737_+|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00272743

Protein sequences

>NZ_CP018870.1|WP_052680510.1|7076383_7076833_-|PRC-barrel-domain-containing-protein
MITQEQIAAMEGCTAFTGQGQRLGLVEYILVDDTTGRPEWVRIIDRASGLGGVFVPLREADLESGRLVVPYPVTVIEQAPCAALDCGSVLSVAEETQLFRHYGVRDARDEVHAEGRAGWAVMDRAQTIREGTAGQANAVSRLQQVQPGR
>NZ_CP018870.1|WP_045321563.1|7076019_7076211_-|hypothetical-protein
MRFLLTALAAGAVVLGTAGAASADVTVDYHPQPSFTIVFGDWSQIAGDDVFSAGHDNTVGSDN
>NZ_CP018870.1|WP_030036351.1|7075379_7075886_+|hypothetical-protein
MRPIRAASLGTATALAALLACAPAVSAAADTEPAPAKDHARVIVLTGRLAEQSRFPVNPGGAPAQGDRTVFRSILFDKDGQEVGETGGTCTTTRVTNGGAEECVVTYVLPGGQLAVQGMVFGHLVPGPPPSFDNAITGGTGKFDRARGSVHADTIGTGVRRFTIDLER
>NZ_CP018870.1|WP_045321564.1|7074683_7075169_-|DUF2975-domain-containing-protein
MGRLTVGTLRGVLAVVLTGTVLVQASMVWALGNDPEEGSLPLTPLRVITILGMVTAQVALVCVWRLVTMVRRGTVFSHAAFRYVDGVIWAIVAAALLWFAVTAINAPGQREDPGVTVIMGGIGLAVLGVALIVLVLRMLLAQAVARDGEAARMRAELDEVI
>NZ_CP018870.1|WP_045321565.1|7074438_7074684_-|helix-turn-helix-transcriptional-regulator
MPIAVDIDVMLARRKMSVGELADRVGITPANLAVLKNGRAKAVRFATLAALCEVLECQPGDLLRWEAEDAEDSATADAVEA
>NZ_CP018870.1|WP_075971779.1|7073662_7074316_-|hypothetical-protein
MAWKGVRRTAAPAALAGGRPRPGGSGPRPSPTPPPPRLPRDFRGKGRWIVRDGDSQLAAGGPQCPIWFTNLIYRDTLCTLTYKWPGLYEHPCSRIPGFNLESLNRRFENVRFVGRQTLRRTPQRHVNHWRVGVVLPDLPPGNHPRVPFALGDIHVDEEDRGTFWQALRFGVQNLYDPELDEWLVMDTHPPRHRHRHSHSHSHSHRTPDKHVAWNANG
>NZ_CP018870.1|WP_107484877.1|7073042_7073681_-|hypothetical-protein
MERERLTFDGWIAAVGTASGTRVVVGHWPRSPFGPFSDVMVERADGRRTLIAPTTRIAEYVSGVYHFDEVRTDPVSVRIRAGGIGVAAGPLELRFRVGRPGILGLALLAVPRALARRPSWAAVTDGPARLMAGVRTRGSSRPGYRQWYAATGLWPITTARASLDGTDLGGLAPVFPPVRFGFASAPATPALVRVLSTVEHRAGGPDTPARGG
>NZ_CP018870.1|WP_030036342.1|7070794_7072630_-|CocE/NonD-family-hydrolase
MSHSQDDNPITPVTAAQLTRIAGHGIYSSPTAVDPAAVNVAEALVATLNGTAETTLLTPELQQLTEQVRQKATFGFPRITAEDGVELSAHTIRLNTSEPRPVVIVPAGWTPFGWILFEYAYLQLALRGYHVLAYTPRGIGLTSPLPGGGYVDAPWTSGGTIDVAGPADRTDGSTVIDYAQQHFNPSRIAFFGESYGSGISQLVAATDPAGRVDAVVALSTWGDLADSLYHNGTRHLKAVQSLIDFTGGPEERKFDAATRQVLDDFRAGRNPDGVVAWGRKRSPSTYADATNARGIPTFISNTWHETLFPANQAVEHFERLTVPKRLNLWIGDHAAPEGAGLTIPFSGPNLPVEEAFAWLDHHVLGADNGVADWPAVNSQIMFTYTTRTDPETGQNVITEPAVREPRPSWSDVTTSTERWYLTATGAGRQDGGLGTAPETGWKLEFTAGELTAATAVDAVITTGQAEWKGNPKQYATDAFDRRHLAVWTSGPLQTARRIRGVPELTLTVRSSADATTLVAYLFDVGPDDTARIITHEPVTLRDLSSGENRDTTWQLQAAGYDIAPDHRLMLVVNSRDQLYSDAHTDAGGNGGSTTTITSTDDSAAHLVLPLG
>NZ_CP018870.1|WP_075971778.1|7070118_7070523_-|VOC-family-protein
MSVQLNHTIVHSRDNRESAEFLAHVLGLEVGAEWGPFIPVDTANGVTLDFATIPAETITPQHYAFLLSEEEFDVAFGKIRAAGIPYFADPHGRLPGEINHNDGGRGVYFTDPAGHGMEIITRPYGYQEPAATGR
>NZ_CP018870.1|WP_030036337.1|7069261_7069675_-|hypothetical-protein
MKSVVRAVSVLVLALGTAVFGNGFAVAASASDEVPVIIQCNNPTNLSLVDASGGDSLVSQLIELITEDGGTGTNDGNNASAVETGAGGTAFGGNASQSANNNRCGQSSDVDASTRVDNSQRIDNSRNLTFDNGPSLL
>NZ_CP018870.1|WP_075971781.1|7077479_7077737_+|hypothetical-protein
MSGPMAGESSCQMMERLADDLRESITKASERAAKIKARIAELKAQAHPDQSQISALEQTLEVLLKKIEDDRTSLADLESVISENC
>NZ_CP018870.1|WP_075971782.1|7077893_7078409_+|N-acetyltransferase
MLIRRETPADLAAVRAVTIASSYKPHEEEPVEVILRDSLRKGEDRIPALSLVAEDKDGAIIGHALCTWGRIGTVRVPNISLLGVHCDHRRRGFGTALIHAALAAADALDAPMVAVLGDPDFYGRFGFRPSTDLGIVGEEPAWEHMFQIRTLTAYDQSVQGEFIYPEPFGSI
>NZ_CP018870.1|WP_075971783.1|7078528_7078999_+|NUDIX-domain-containing-protein
METTHRPAARVLCLDAAHRLLLLHWRDPFDGTWLWEPPGGGIEPGETPLVAARRELAEETGLDPAAVLDRSVPVDRDVRWNGKRYIGTEYFFLARFADERPSLVRTGLLPDEQATLDAHAWIEWSDLSSLRDPVEPPQLPAVLGALAPDGPWRVRG
>NZ_CP018870.1|WP_075971784.1|7079144_7079459_-|TraR/DksA-family-transcriptional-regulator
MACDRPNFDGIVAANALVAVDDEHDPEGGTTAFERAHVAALMAQAREHLEELDEALRRLEQGRYGHCDVCGGAIPPERLEIRPAATTCVRCARSTTSRRPAHPA
>NZ_CP018870.1|WP_075971785.1|7080630_7080852_-|hypothetical-protein
MFRSDGVGAAEGRRAYPDTDVTPDDALASIDDARLQRRRQAAVAEAAALRRVRAERAGANRAVGASPPAAGIR
>NZ_CP018870.1|WP_159393599.1|7081796_7082129_+|hypothetical-protein
MLTKRPSGTHFSQSSATDGQSPLARDDGNTLNTHAVLFNGDKAALAIFAAGAAVTFAVVEVAPHVKNGLISLKSKLSRRAEDPADKPFAPLTVVAEAEPEQPEPPRLRAV
>NZ_CP018870.1|WP_159393600.1|7082617_7082767_+|hypothetical-protein
MFLSSGPCRLRRTPGEAEVLVYADVHQSPDEGGYLDPAEEAEGAGAFLR
>NZ_CP018870.1|WP_075971787.1|7082873_7083287_-|hypothetical-protein
MDPLLHLDRTLDDLDPPSWDAVPADATRLVRTVHGLRRVPLGELRPADLRTLLAQQVALPFVLPLAVRLLAEEPLLDAYFYEGDLLLATVTAPEGAWAALPELEARLRTIVAGLPDAAVKELPRGSDTDLARFITRG
>NZ_CP018870.1|WP_075972344.1|7085370_7085880_+|hypothetical-protein
MNDGRQADTERRRSRVTSAITTARRDASPLTASAIARAARVDRTFLYRHRDLLDALHTAAHEPATPSGTGSTVTSVSLQADLANAGARSARLTARVQQLEERLSKALGEEIWRASGLGPPADVAELNSRITRLEQSNVELTRAVEERQAELEAARAANRDLTRALNQKS
>NZ_CP018870.1|WP_075971789.1|7085923_7087075_-|HEAT-repeat-domain-containing-protein
MTDYRDAVLRLWGRQLYERQGEPLAWAEAVLEATSRPPTAVTTAMSGRLDALADSPSDRATLLFRTVAKLAANLRGDGHYDADVGTRIGPMALQLGELEPPLAGPLGDALGHPPDGPTSLVTVHAAELSRNRTIRLRAIDALLEWAELGHPQARAALSEVASDHRTQDVTVWTKALNRIALFGDASVEPGLLRALADTGHRGVRWSALACAELGFRRAVPLITALLEHPDPMVREGACEALGLLEEHAAVPALAARLNDETDWVRSRAALALGQIGSDRALAALWQTMMERRNPKASHLASAIATFGPPVVDNLIALTTDPDPDLRALACRALGSTADERALPALEHLAAHDLARTTLGGLVATAAKQGLRTAHRIRARTAST

Crispr_ID: NZ_CP018870_20

• CRISPR_ID: NZ_CP018870_20
• CRISPR_location: 7303527-7303718
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NZ_CP018870_20

Consensus_repeat	Method
CGGAGAAGGCCCCNGNCA	CRT

spacers of NZ_CP018870_20

>20.1|7303545|30|NZ_CP018870|CRT
AGGCCCCTGAGAAGGCCCCGGACAAAGCTC
>20.2|7303593|18|NZ_CP018870|CRT
CAGCTCCGGAGAAGGCTC
>20.3|7303629|30|NZ_CP018870|CRT
CGGCTCCGGAGAAGGCCCCGGACACAACTC
>20.4|7303677|24|NZ_CP018870|CRT
AGGCCCCGCAGGAGGCTCCGGCGA

CRISPR arrays and Neighbor proteins around NZ_CP018870_20

CRISPR arrays

The CRISPR arrays of NZ_CP018870_20

>merge|NZ_CP018870|20|7303527-7303718|CRT
CGGAGAAGGCCCCTGAGAAGGCCCCTGAGAAGGCCCCGGACAAAGCTCCGGAGAAGGCCCCGGACACAGCTCCGGAGAAGGCTCCGGAGAAGGCCCCGGACACGGCTCCGGAGAAGGCCCCGGACACAACTCCGGACAAGGCCCCGGGCAAGGCCCCGCAGGAGGCTCCGGCGAAGGAGCAAAGCCCTGGCA

>NZ_CP018870|20|2|7303527-7303718|CRT
CGGAGAAGGCCCCTGAGA	AGGCCCCTGAGAAGGCCCCGGACAAAGCTC
CGGAGAAGGCCCCGGACA	CAGCTCCGGAGAAGGCTC
CGGAGAAGGCCCCGGACA	CGGCTCCGGAGAAGGCCCCGGACACAACTC
CGGACAAGGCCCCGGGCA	AGGCCCCGCAGGAGGCTCCGGCGA
AGGAGCAAAGCCCTGGCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_045324024.1|7290787_7291786_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|223135
NZ_CP018870.1|WP_075971860.1|7299758_7301240_-|MFS-transporter	unknown	unknown	gnl|CDD|129794
NZ_CP018870.1|WP_030036165.1|7293031_7293676_-|LysE-family-translocator	unknown	unknown	gnl|CDD|224199
NZ_CP018870.1|WP_075971861.1|7301323_7301890_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP018870.1|WP_045324010.1|7306391_7307144_+|anti-sigma-factor	unknown	unknown	gnl|CDD|378389
NZ_CP018870.1|WP_030031395.1|7314654_7315269_+|pyrimidine-reductase	unknown	unknown	gnl|CDD|223340
NZ_CP018870.1|WP_078849266.1|7305735_7306395_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|182015
NZ_CP018870.1|WP_030036167.1|7291990_7292947_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|181818
NZ_CP018870.1|WP_075971858.1|7297097_7297694_-|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
NZ_CP018870.1|WP_078849267.1|7311614_7312283_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|366166
NZ_CP018870.1|WP_075971857.1|7295273_7297004_-|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173838
NZ_CP018870.1|WP_037664266.1|7312283_7314407_-|MMPL-family-transporter	unknown	unknown	gnl|CDD|225272
NZ_CP018870.1|WP_107069733.1|7308498_7309245_+|DUF1365-domain-containing-protein	unknown	unknown	gnl|CDD|377778
NZ_CP018870.1|WP_075971859.1|7299235_7299730_-|hypothetical-protein	unknown	unknown	gnl|CDD|176871
NZ_CP018870.1|WP_075971866.1|7310689_7311511_+|DUF1295-domain-containing-protein	unknown	unknown	gnl|CDD|226275
NZ_CP018870.1|WP_079273522.1|7307260_7308502_+|NAD(P)-binding-protein	unknown	unknown	gnl|CDD|225459
NZ_CP018870.1|WP_051873543.1|7297783_7299157_-|dioxygenase	unknown	unknown	gnl|CDD|376981
NZ_CP018870.1|WP_079273521.1|7304972_7305476_+|hypothetical-protein	unknown	unknown	gnl|CDD|273727
NZ_CP018870.1|WP_079273388.1|7309241_7310693_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|225139
NZ_CP018870.1|WP_075971856.1|7293945_7295178_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235729

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_045324024.1|7290787_7291786_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl|CDD|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	1.34884e-170
NZ_CP018870.1|WP_075971860.1|7299758_7301240_-|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	8.61133e-63
NZ_CP018870.1|WP_030036165.1|7293031_7293676_-|LysE-family-translocator	gnl|CDD|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	9.09864e-40
NZ_CP018870.1|WP_075971861.1|7301323_7301890_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.69037e-12
NZ_CP018870.1|WP_045324010.1|7306391_7307144_+|anti-sigma-factor	gnl|CDD|378389	pfam10099, RskA, Anti-sigma-K factor rskA. This domain, formerly known as DUF2337, is the anti-sigma-K factor, RskA. In Mycobacterium tuberculosis the protein positively regulates expression of the antigenic proteins MPB70 and MPB83.	1.40787e-24
NZ_CP018870.1|WP_030031395.1|7314654_7315269_+|pyrimidine-reductase	gnl|CDD|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	6.70845e-16
NZ_CP018870.1|WP_078849266.1|7305735_7306395_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|182015	PRK09646, PRK09646, ECF RNA polymerase sigma factor SigK.	7.83589e-81
NZ_CP018870.1|WP_030036167.1|7291990_7292947_-|helix-turn-helix-domain-containing-protein	gnl|CDD|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	3.81626e-109
NZ_CP018870.1|WP_075971858.1|7297097_7297694_-|PadR-family-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.7687e-21
NZ_CP018870.1|WP_078849267.1|7311614_7312283_+|alpha/beta-fold-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	2.98007e-05
NZ_CP018870.1|WP_075971857.1|7295273_7297004_-|acyl-CoA-dehydrogenase	gnl|CDD|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	2.49137e-40
NZ_CP018870.1|WP_037664266.1|7312283_7314407_-|MMPL-family-transporter	gnl|CDD|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	7.86592e-71
NZ_CP018870.1|WP_107069733.1|7308498_7309245_+|DUF1365-domain-containing-protein	gnl|CDD|377778	pfam07103, DUF1365, Protein of unknown function (DUF1365). This family consists of several bacterial and plant proteins of around 250 residues in length. The function of this family is unknown.	9.54924e-91
NZ_CP018870.1|WP_075971859.1|7299235_7299730_-|hypothetical-protein	gnl|CDD|176871	cd08862, SRPBCC_Smu440-like, Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Streptococcus mutans Smu.440 and related proteins. This domain belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Streptococcus mutans is a dental pathogen, and the leading cause of dental caries. In this pathogen, the gene encoding Smu.440 is in the same operon as the gene encoding SMU.441, a member of the MarR protein family of transcriptional regulators involved in multiple antibiotic resistance. It has been suggested that SMU.440 is involved in polyketide-like antibiotic resistance.	3.6328e-27
NZ_CP018870.1|WP_075971866.1|7310689_7311511_+|DUF1295-domain-containing-protein	gnl|CDD|226275	COG3752, COG3752, Steroid 5-alpha reductase family enzyme [General function prediction only].	4.11392e-70
NZ_CP018870.1|WP_079273522.1|7307260_7308502_+|NAD(P)-binding-protein	gnl|CDD|225459	COG2907, COG2907, Predicted NAD/FAD-binding protein [General function prediction only].	5.13124e-141
NZ_CP018870.1|WP_051873543.1|7297783_7299157_-|dioxygenase	gnl|CDD|376981	pfam03055, RPE65, Retinal pigment epithelial membrane protein. This family represents a retinal pigment epithelial membrane receptor which is abundantly expressed in retinal pigment epithelium, and binds plasma retinal binding protein. The family also includes the sequence related neoxanthin cleavage enzyme in plants and lignostilbene-alpha,beta-dioxygenase in bacteria.	6.2892e-109
NZ_CP018870.1|WP_079273521.1|7304972_7305476_+|hypothetical-protein	gnl|CDD|273727	TIGR01642, Splicing_factor_U2AF_59_kDa_subunit, U2 snRNP auxilliary factor, large subunit, splicing factor. These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.	0.000572371
NZ_CP018870.1|WP_079273388.1|7309241_7310693_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|225139	COG2230, Cfa, Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane].	4.7823e-106
NZ_CP018870.1|WP_075971856.1|7293945_7295178_+|FAD-dependent-oxidoreductase	gnl|CDD|235729	PRK06185, PRK06185, FAD-dependent oxidoreductase.	0

Protein sequences

>NZ_CP018870.1|WP_075971861.1|7301323_7301890_-|TetR/AcrR-family-transcriptional-regulator
MNTERRRQLSSAEERRETVLGTAIGAFAARGYFGTTTTEVAKAAGISQAYVYRLFPNKEALFTAVVERCFTRVRTSLEEGAAQAQGSSPEAVLHTMGDTYARLIADKDLLLVLTHAQAAAVSETAVREAVRAGYARMVEYVRGASGAAEADVQQFFATGMLCHLLVSLDAHEVDAPWSRTLADGIRHY
>NZ_CP018870.1|WP_075971860.1|7299758_7301240_-|MFS-transporter
MDATPPDRRTPAPAAAALVALAAAQFAVTLSTSIVNVALPAVRDGVGLSDAGMSWVVNAYGLAFGALLLLGGRAADLLGRRRVLTAGLAVFTVAAVAAGLASTPWMLVTARTAQGVGAAAIAPAALSLVMRLHPPGTARARALGVWGAVSGAGGAAGVVLGGVLTEGPGWPWVFHASGVGAAVVLAATLRLVPADRKEDAEPRSRLDATGALTVTSGLVALVFGLTAAGRSGWTDPLVLGSFGAAAVLLTLFVRLERRHPAPLLPPRLLTRGAAGPANLVMALLGAVWVGLFFFLPLYQQQVLGASALEAGLSQLPLAAANMIGSGLAPVLARRIGPHRTLLAGLAVQAAGFLWLARIPADGTFLVHLLGPVLLVGAGLGTTFVQLTGAAVDGVEPADAGVAGGLVNTTRQVGGAVGLAVLGTLAAARTAASDLPHTAALTEGYRAAFLMSAAVLGVGAALTPLLARGTRPPRGTVPAAPPPPTAVRPPSRTR
>NZ_CP018870.1|WP_075971859.1|7299235_7299730_-|hypothetical-protein
MTTHPTAVDSEAPVVVRVETTVHAPLPTVWSLHTDIAAWPDWNTDVDRVEYAGPLTPGTAFRWLTHGLDITSTVHQVVPGERIVWGGPAHGIDGIHVWTFQETAPGTVTVRTEESWSGAPVEARPTEMEQVLRQSLDAWLAALKVRAEAEAAAAATATTAPERD
>NZ_CP018870.1|WP_051873543.1|7297783_7299157_-|dioxygenase
MPKPYLTGHYTPVTDEITATGLTVEGTIPPELSGRLIRNSHNPKPGITPTHWFKGSGMVHGIRLRDGRAEWYRNRWVHTPALDGAPYMTDKGPDLTASTAGTHVIEHAGRLLALSEAALPFELTADLDTVGAYDFGGRLTSAMTAHPKEDPVTGELHFFASSPFPPYLVHHVATADGQVLESQEVPGASAALKHDFALTEHYVVFLEGSVTFDPAERSGIPYSWDDEQISRIGVMPRTAAGAGGGGRAREIRWFEIGQGYGMHFANAYEDPHGRIVVEGPSVGREGWQRSWNWWVGAEDRGAEPNHGSRSTRWTVDLAAGAVKEEVTDDLTVEFPTINDAFLGIEHRYQYALAFPDDMGTAAHTLVKYDRSTGARQLLPFGAGRLPSEAVFVPAEGAGASQEDAGYLLTVVSDLHANASQLLVLDAGDLTVPPVATIHLPRRVPAMIHGSWIPDASA
>NZ_CP018870.1|WP_075971858.1|7297097_7297694_-|PadR-family-transcriptional-regulator
MALEHAILVSLLEKPGSGYELARRFDRSIGYFWTATHQQIYRVLKRMESDGLLAVRTIPQQGRPDKKEYSAAGPGRAALARWLHEPIEPESLRHDLAVKIRGAAFDDPASLIREVERHQQAHRDRLTRYLAGELRDFTGPDAPAPLDAGQELQHVVLRGGIAQERMTIAWLDDVLATLHRLGRTAPPAPPAPPAPPAS
>NZ_CP018870.1|WP_075971857.1|7295273_7297004_-|acyl-CoA-dehydrogenase
MSDPLLFHPHTYDPAHFDPETRRLLRATVDWFEARGKRRIIEDYRTRAWLADFLAFSAKEGLFATFLTPAAAAGEDEPDKRWDTARIAALNEIFGFYGLDYWYAWQVTILGLGPVWQSDNAAARERAAQLLSEGEVFAFGLSEKTHGADIYSTDMLLEPSTDGSGGFRASGSKYYIGNGNAAGLVSVFGRRTDVEGPDGYVFFAADSRHPAYRLVKNVVDSSKYVSEFRLEDYPVSAEDVLHTGRAAFDAALNTVNVGKFNLCTASIGICEHAMYEAVTHAHNRILYGRPVTAFPHVRRELADAYVRLVGMKLFSDRAVDYFRSAGPDDRRYLLFNPMTKMKVTTEGEKVIDLMWDVIAAKGFEKDNYFAQAAVEIRGLPKLEGTVHVNLALILKFMRNHLLAPAEYEPVPTRLDAADDDFLFRQGPARGLGSVRFHDWRPAYDSYAAVPNVARFREQADALAEFAATIAPDEAQGRDLDFLLSVGQLFALVVHGQLILEQARLTDLDESVLDELFSVLVRDFSQHAVELHGKDSSTPEQQAWALAAVRRPVVDEARSARVWARVEALSGAYEMAQ
>NZ_CP018870.1|WP_075971856.1|7293945_7295178_+|FAD-dependent-oxidoreductase
MERTTCCVVGGGPAGMVLALLLARAGVEVSVLEKHGDFLRDFRGDTVHPTTLSLLDDIGLAERFARLPQRRVTTVQLPIGPDRTLVTVGNIGALPGKYNYIAMVPQWDLLDLLADEARREPAFHLRMDTEATGFLVEGGRVRGVRYRTADGATGELRATLTVACDGRGSLARALPELGLEHFPCPMDAWWFRLPRHESDPSGLVGGLGDRFFTALIDRGDYWQCAALIPKGTDAERRAEGLERFMDRFAEAAPWLADRSHAVSSWDEVKLLDVRLDRLRRWHRPGLLCIGDAAHAMSPVGGIGINLAVQDAVATARHLVRPLREGRVGLNDVRRVQFRRWPTTVATQGLQRLAHAQVFEPILEGRTAFGDPRRAQRMTELVTESPWLNRIPAYFIAYGALRERPPAESLR
>NZ_CP018870.1|WP_030036165.1|7293031_7293676_-|LysE-family-translocator
MISLAAVGGVALIELGMALTPGPNMIHLASRAITQGRRAGLVSLSGTAVGFVCYLVAAAAGLSALFAAVPLAFTVVKLAGAAYLAYLAWGMLKPGGRSPFAPAGDLPPVSDTRLFSTGLLTNLLNPKIALMYAALLPQFMDPQAGPDWAQLLQLGGVQIVVGISVNGLIMLGAARVSGFLAARPRVMTAQRLASGGLLGFFALRTALSRTPAAA
>NZ_CP018870.1|WP_030036167.1|7291990_7292947_-|helix-turn-helix-domain-containing-protein
MPASPLHRVAVLVLEGAKPLDVGIPAQVFTTRASMPYEVRVCGAAPGLVAGGDGLSYHVTHGLDALAWADIVFVPGYRFPDREDPPRPVIDALIAAHERGARLAAISTGAFALAATGLLDGKRATTHWHYARALTAKHPLVRVDENVLFVDEGSVLTSAGAASGIDLCLHILRGDLGVAASNHAARRLVAAPYRSGGQAQYVPRSVPEPLGERFAATREWALRRLGEPLTLESLARHAGVSPRTFSRRFSEDTGYTPMQWVMRARIDVARELLERSQRGVEQIAADVGLGTGANLRLHFQRILGTSPTEYRRTFTKGE
>NZ_CP018870.1|WP_045324024.1|7290787_7291786_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MTRIAINGFGRIGRNVLRALLERDSDLEVVAVNDLTEPKALARLLAYDSTSGRLGRPVTVDGNTLVVDGRRITVLAEREPEQLPWADLGVDIVLEATGRFTSADAARAHLKAGAKKVLVSAPSDGADVTLAYGVNTDAYDPAVHTIVSNASCTTNALAPLAAVLDELAGIEHGFMTTVHAYTQEQNLQDGPHRDPRRARAAGVNIVPTSTGAAKAIGLVLPQLDGKLQGDSIRVPVPVGSIVELNTTVAREVTREEILEAYRAAAEGPLAGVLEYSDDPLVSSDITGNPASSIFDSELTRVEGRHVKVVAWYDNEWGFSNRVIDTLTLLAAG
>NZ_CP018870.1|WP_079273521.1|7304972_7305476_+|hypothetical-protein
MTASTNVKRVAVSVASTGLLAGGSLLGLSGTANAAPATANSMPTSTSTSTSTSTSTNDRDRDHDHDRDRNRDDHWDRHNRHDRHDRWDRRDHHDRCSWVKGHWVTGKWGKGHWEAKWHPGSWLPGHRDHHGRWHDGWWSKGYWKQHWVPGHPVSHWVPGHWNCHDKW
>NZ_CP018870.1|WP_078849266.1|7305735_7306395_+|sigma-70-family-RNA-polymerase-sigma-factor
MPLRPVAAAGARPVNHPLPFGPGRTGRTGRTGRASHAGRSDLCEVMDEVAHGDKHAFSVLYDALAPMVFGIVVRVVRDRAQSEEVAQEVMIDLWRQAARYRADHGSVTAWAATIAHRRAVDRVRSAQASADREQAQAAREHQTAFDEVSEQVETRLESEQVRRCMRGLTELQRQAVTLAYYRGLTYREVAEALRTPLPTVKTRMRDGLIRLRDCMGVTT
>NZ_CP018870.1|WP_045324010.1|7306391_7307144_+|anti-sigma-factor
MKQHHSDVHTLAAAYALNALDPAERKAFTDHLPHCQACRDEVAEFEATAARLADAAAEYPPTALKHHVMAAVDGVRQLPPRVPHTAPSVTVGSALRRRAVPLALAASVVAAASFAGLAAWQNQHIEQHRQRAAQAEQRLDDVSTVLAAPDARAAHGRASNGAATTVVASKRQNRAVFTAAGLPAPAPGTTYQLWLDHDGTMRPAGFIRQDGTVLVDGDTAGAGALGLTVEPAGGSRRPTSAPLLLITLPT
>NZ_CP018870.1|WP_079273522.1|7307260_7308502_+|NAD(P)-binding-protein
MGAGVAGLTAAHVLARSYEVTLYEADGRLGGHAHTHEFSGPDGRPMGVDSGFIVHNERTYPTLLRLFRELGITTQDAEMSMSVRCDGCGLEYAGARGPAGLLTGRAALRGRYLRLLAQVPVFHRRALRLLADPPSHHVTLGDFLREGRFSPYFVSHFALPLVSAVWSCPARTALSYPAAHLFTFLRHHGLLSVTGSPQWKTVTGGSAAYVEAVAKSVHRVRTSSPVRTVHRAARGSGAWISTENGATDGYDAVVIATHPDQALRLLADPTPDERRLLGAFTYAPNPTVLHTDTSLLPRSPRARACWNYHLPDCAPSAEAVRVSYDMKRLQNLPDGADYVVTLGADDRVDPGRVVRRMLYEHPVHTPASVAAQKELPLLNTGVTAYAGAWQGWGFHEDGCRSGVAAARALGVRW
>NZ_CP018870.1|WP_107069733.1|7308498_7309245_+|DUF1365-domain-containing-protein
MTRAAAPAAALYECLVVHTRTAPLRHDVRHRTYLWCVDLDRLPALPGALRPLARFDPRDHFAGRAPTIRAGLEEFLASRDIDIEGGRVMMLAHARVLGFVFNPLSVYWCHDASGSLVCVVAEVHNTYGQRHCYLLHPDAGGRARAEKRFYVSPFFPVEGHYRMRLPLPEDRLHLTVHLDTEAGRPFTATVRGRARPATARGLLRAAARRPWSTAAVWAGIRLHGIRLLLKGLPVQPRPRHTPQKGMVP
>NZ_CP018870.1|WP_079273388.1|7309241_7310693_+|class-I-SAM-dependent-methyltransferase
MTRPATRPDHQLRTAHDRHRTPHDHHRTPDDHPRTADHQVRPSDRGPLPSEPEGEPEPEPRTPDPGAVIRGQVSAARWPDVARLPPARRARTAVAAHLVGRALDRLPLDVNPGTAGGRSATRCRPDITIHDPEAFFRRIGRDGLIGFGESYMAGEWDSGDLTGLLTVLATHVDDLVPARLRGLRPLWAPSRPRRDRNTRSGARRNIHHHYDLSNDLFAAFLDPTLTYSSAVFSVFPARSEDLPAAQQRKIDRLLDLAHVTDGTELLEIGTGWGELALRAAARGARVTTLTLSAEQAELARARIHAAGLTDRVDVQLRDYRDAEGRYDAVVSVEMIEAVGAEYWPSYFAALRGALRPGGRVALQTITMGHRQMRNTAATRTWISKYVFPGGVIPSRRAIAEHAAAAGLRMVSDEGFVEHYAQTLRLWRERFTANRQTVTDLGFDTVFQRMWEFYLAYSEAGFRSRYLDVRQIALAEKPPRAARP
>NZ_CP018870.1|WP_075971866.1|7310689_7311511_+|DUF1295-domain-containing-protein
MNGTAWHALGAGLAAGAAVATAVLLTAFAIGTHLRLHRVADIAWGLAFSGVAVTTYLLSAGHGDPERRLLVAAATVVWGLRLSAHLAWRSRGHGEDPRYTALLDQARGNRTWYALRTVYLLQAALVWLVSLPVQAASYADAPVGVLGVLGLAVWAAGVGFEAVGDHQLARFREDPANRGRIMDGGLWAWTRHPNYFGDCLVWWGLYLLACTSLTSALPLLVSPVVMTALLTAGSGKRLLEKHMGDRPGYAEYAARTSGFLPLPPRHDLSELRR
>NZ_CP018870.1|WP_078849267.1|7311614_7312283_+|alpha/beta-fold-hydrolase
MSRRTEAAVLLLHGGRADALQAPPRLNLPALRMRPFATAVTRATAHADVLVAHVRYRHRGWNGGHAHPVADTLRALDELRAAAGPVPVVLVGHSMGGRAALRAAADPQVVGVVALAPWCPPDEPAAHLRARAVVALHDESDRVTRAADTWAYLTRAREAGARVHGVRMPRGGHAMIGGAGPWHRITAGAAAALLGLGPYPAGLAAPADPAGHTAGTDRPPAR
>NZ_CP018870.1|WP_037664266.1|7312283_7314407_-|MMPL-family-transporter
MRNTPRWARWIVPLALLLVWLGIGGTLGPYAGKLSEVATNDQAAFLPRSAESTKVIEARKAFEGAQSVPAIVVWTADGARVTAAQQEAAARAVGGLAGRPGVTGPPSPAVVSADGLAVQAVVPLAPDLGEELPAVLDEVREAAQRVPGTSVGIAGPAATQADLSDAFAGIDGLLVGVALGAVLLILLLVYRSVLLPLVIIVSAVFALGLACAVVYALADRGLVRVDGQVQGILSILVIGASTDYALLVAARFREELAVRGDRAEAAWAAVRRSAGAVTASAATVALGLLALLASDLTNNRALGPVGAIGIVCAVLSSLTFLPAVLVLLGRTAYWPAVPGPADAAGEGRGVWRRIAGLIDRSPRRVWVSTSVLLVVLAGFSPALSSKGVPLDEIFVNDAPSVGAQQTLARHFPGGSGNPAVVIADADRAAEVRAAAEGTDGVAAVVPVTAGGRPGGPGAPLVVDGRVRFDATLEAAADSDAAKRTVERLRERVHAVPGADALVGGYTAQQFDTQQTSARDRTVIVPIVLGIILLILIALLRSVLVPVLLVATVALNFLATLGVSALVFGNLLGFSGTDASVPLYGFVFLVALGVDYNIFLMSRVREETVRSGTRAGVLRGLVTTGGVITSAGVVLAATFAALMVIPLAFLVQIAFIVAFGVLLDTLVVRSLLVPALIVDIGPRAWWPSALSRPDGGSGARTERAARAR
>NZ_CP018870.1|WP_030031395.1|7314654_7315269_+|pyrimidine-reductase
MRKIKAQLFISLDGVVEAPDQWHFPYFDEDMGAAVDATLGRADTLLLGRRTYDSFAGAWPEREAAGGEDAPFARVLGDARKIVVSNSPLTFTWRNCEQLAGDLTAGVAALKEEPGADTPVWISGSVSVVRRLIADGLLDELNLLLHPIAVRTGMRLFEQDATPVPLELVSAETFRTGVLNLSYALAAAPGEATYEDAKSHLPQQ

Crispr_ID: NZ_CP018870_21

• CRISPR_ID: NZ_CP018870_21
• CRISPR_location: 7416728-7416853
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_21

Consensus_repeat	Method
TCCTGACCCCCCGAAGGCAACCCCACCGACCCTGACC	CRISPRCasFinder

spacers of NZ_CP018870_21

>21.1|7416765|52|NZ_CP018870|CRISPRCasFinder
CGGTAGGGGCGACCCCCGCCGACCCTGAACCGGGTGTGGGCAACGGCGCCGG

CRISPR arrays and Neighbor proteins around NZ_CP018870_21

CRISPR arrays

The CRISPR arrays of NZ_CP018870_21

>merge|NZ_CP018870|21|7416728-7416853|CRISPRCasFinder
TCCTGACCCCCCGAAGGCAACCCCACCGACCCTGACCCGGTAGGGGCGACCCCCGCCGACCCTGAACCGGGTGTGGGCAACGGCGCCGGTCCTGCCCCCCCGAAGGCAACCCCACCGACCCTGACC

>NZ_CP018870|21|19|7416728-7416853|CRISPRCasFinder
TCCTGACCCCCCGAAGGCAACCCCACCGACCCTGACC	CGGTAGGGGCGACCCCCGCCGACCCTGAACCGGGTGTGGGCAACGGCGCCGG
TCCTGCCCCCCCGAAGGCAACCCCACCGACCCTGACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_075969562.1|7406266_7407847_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030032619.1|7421253_7421538_+|DUF3253-domain-containing-protein	unknown	unknown	gnl|CDD|371633
NZ_CP018870.1|WP_051873430.1|7422547_7422928_-|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NZ_CP018870.1|WP_079273066.1|7415076_7415916_+|DUF2071-domain-containing-protein	unknown	unknown	gnl|CDD|378271
NZ_CP018870.1|WP_045324329.1|7421962_7422406_+|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl|CDD|380090
NZ_CP018870.1|WP_159393493.1|7412428_7413313_+|hypothetical-protein	unknown	unknown	gnl|CDD|273344
NZ_CP018870.1|WP_075971917.1|7422981_7423674_-|HSP18-transcriptional-regulator	unknown	unknown	unknown
NZ_CP018870.1|WP_030031413.1|7409753_7409966_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030032941.1|7424409_7424805_+|DUF2267-domain-containing-protein	unknown	unknown	gnl|CDD|378360
NZ_CP018870.1|WP_030033911.1|7407870_7408350_+|diadenosine-tetraphosphate-hydrolase	unknown	unknown	unknown
NZ_CP018870.1|WP_075969558.1|7418557_7419205_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_030032938.1|7423833_7424268_+|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl|CDD|223149
NZ_CP018870.1|WP_075969561.1|7408968_7409532_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379112
NZ_CP018870.1|WP_030033937.1|7420215_7421121_-|allantoinase-PuuE	unknown	unknown	gnl|CDD|211797
NZ_CP018870.1|WP_075969559.1|7413723_7414821_+|hypothetical-protein	unknown	unknown	gnl|CDD|312941
NZ_CP018870.1|WP_159393494.1|7404545_7405934_-|glycoside-hydrolase-family-15	unknown	unknown	gnl|CDD|273702
NZ_CP018870.1|WP_030032943.1|7424873_7425320_+|DUF2267-domain-containing-protein	unknown	unknown	gnl|CDD|378360
NZ_CP018870.1|WP_030031414.1|7410242_7410725_-|lamin-tail-domain-containing-protein	unknown	unknown	gnl|CDD|376421
NZ_CP018870.1|WP_037665107.1|7411155_7412142_-|MsnO8-family-LLM-class-oxidoreductase	unknown	unknown	gnl|CDD|274646
NZ_CP018870.1|WP_030033448.1|7419519_7419978_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_030032619.1|7421253_7421538_+|DUF3253-domain-containing-protein	gnl|CDD|371633	pfam11625, DUF3253, Protein of unknown function (DUF3253). This bacterial family of proteins has no known function.	5.35299e-27
NZ_CP018870.1|WP_030032941.1|7424409_7424805_+|DUF2267-domain-containing-protein	gnl|CDD|378360	pfam10025, DUF2267, Uncharacterized conserved protein (DUF2267). This domain, found in various hypothetical bacterial proteins, has no known function.	4.81335e-19
NZ_CP018870.1|WP_079273066.1|7415076_7415916_+|DUF2071-domain-containing-protein	gnl|CDD|378271	pfam09844, DUF2071, Uncharacterized conserved protein (COG2071). This conserved protein (similar to YgjF), found in various prokaryotes, has no known function.	9.5383e-88
NZ_CP018870.1|WP_045324329.1|7421962_7422406_+|transglycosylase-SLT-domain-containing-protein	gnl|CDD|380090	pfam18013, Phage_lysozyme2, Phage tail lysozyme. This domain has a lysozyme like fold. It is found in the tail protein of various phages probably giving them the ability to degrade the host cell wall peptidoglycan layer.	1.07051e-05
NZ_CP018870.1|WP_159393493.1|7412428_7413313_+|hypothetical-protein	gnl|CDD|273344	TIGR00927, retinal_rod, K+-dependent Na+/Ca+ exchanger. [Transport and binding proteins, Cations and iron carrying compounds].	1.91506e-10
NZ_CP018870.1|WP_051873430.1|7422547_7422928_-|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.47329e-21
NZ_CP018870.1|WP_030032943.1|7424873_7425320_+|DUF2267-domain-containing-protein	gnl|CDD|378360	pfam10025, DUF2267, Uncharacterized conserved protein (DUF2267). This domain, found in various hypothetical bacterial proteins, has no known function.	1.76098e-23
NZ_CP018870.1|WP_030032938.1|7423833_7424268_+|Hsp20/alpha-crystallin-family-protein	gnl|CDD|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	1.051e-27
NZ_CP018870.1|WP_075969561.1|7408968_7409532_-|GNAT-family-N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.33929e-22
NZ_CP018870.1|WP_075969559.1|7413723_7414821_+|hypothetical-protein	gnl|CDD|312941	pfam09606, Med15, ARC105 or Med15 subunit of Mediator complex non-fungal. The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.	0.00319284
NZ_CP018870.1|WP_030033937.1|7420215_7421121_-|allantoinase-PuuE	gnl|CDD|211797	TIGR03212, uraD_N-term-dom, putative urate catabolism protein. This model represents a protein that is predominantly found just upstream of the UraD protein (OHCU decarboxylase) and in a number of instances as a N-terminal fusion with it. UraD itself catalyzes the last step in the catabolism of urate to allantoate. The function of this protein is presently unknown. It shows homology with the pfam01522 polysaccharide deacetylase domain family.	5.87648e-151
NZ_CP018870.1|WP_159393494.1|7404545_7405934_-|glycoside-hydrolase-family-15	gnl|CDD|273702	TIGR01577, Uncharacterized_glycosyl_hydrolase_MJ1610, oligosaccharide amylase. The name of this type of amylase is based on the characterization of an glucoamylase family enzyme from Thermoactinomyces vulgaris. The T. vulgaris enzyme was expressed in E. coli and, like other glucoamylases, it releases beta-D-glucose from starch. However, unlike previously characterized glucoamylases, this T. vulgaris amylase hydrolyzes maltooligosaccharides (maltotetraose, maltose) more efficiently than starch (1), indicating this enzyme belongs to a class of glucoamylase-type enzymes with oligosaccharide-metabolizing activity.	2.49536e-26
NZ_CP018870.1|WP_030031414.1|7410242_7410725_-|lamin-tail-domain-containing-protein	gnl|CDD|376421	pfam00932, LTD, Lamin Tail Domain. The lamin-tail domain (LTD), which has an immunoglobulin (Ig) fold, is found in Nuclear Lamins, Chlo1887 from Chloroflexus, and several bacterial proteins where it occurs with membrane associated hydrolases of the metallo-beta-lactamase,synaptojanin, and calcineurin-like phosphoesterase superfamilies.	9.32534e-19
NZ_CP018870.1|WP_037665107.1|7411155_7412142_-|MsnO8-family-LLM-class-oxidoreductase	gnl|CDD|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	2.83026e-114

Protein sequences

>NZ_CP018870.1|WP_079273066.1|7415076_7415916_+|DUF2071-domain-containing-protein
MQHPPPPGPGPAAPGPAAPSPAAPAGLGPAAPGPAAPAEPITPDAPRHPGVDRPLLTQSWLDLTFVHWPADPADVAPLLPAGTAPDTLDGVTYVGLVAFRMHRVGWLRLPGIPYLGSFPETNVRLYSIDGHGRRGVVFRSLDASRLIPVLAARTVFRLPYQWSRMSVRRDGPTLTYTSRRHWPGPRGAHSTLTVRTGPPLTQPTALEHFLTARWALHSDFRGRLLYLPNSHPRWPLHHAELLRCDEDLTVAAGLPAPAGPPASVLYSPGVPVRFTRPTG
>NZ_CP018870.1|WP_075969559.1|7413723_7414821_+|hypothetical-protein
MSRKKHVANIAGLSCVTAILAGTAGVAVAQPSALPTAAPAAVCSLKGGEIHGNGFALKQTYDVKRSGKTIARVAAGPKGDIRVGITGAGPFSVGTVKCASTGSTAASTKTDMAAATARGAAAAQQAARGGASKTQAAAIGRKAAASEAKRLGLAPAVVNQVTNNVTNIVNNTIIGGSNNTIGGTQIGNGNTQGGTQGAGNGNTQGGTQGAGNGNTQGGTQGGGNGNTQGGTQGGGTGNTQGGTQGGGNGNTQGGTQGGGTGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGTGSTQGGTQGGGTGSTQGGTQG
>NZ_CP018870.1|WP_159393493.1|7412428_7413313_+|hypothetical-protein
MNRKFETSETPRPKRRGFRLATAVAAAAIAGGVLIPTSSAMAAPTTSVESVVSHNQHDHKKKHDHKKHEDNHKKKKRNKHGGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQGGGSGNTQGGTQG
>NZ_CP018870.1|WP_037665107.1|7411155_7412142_-|MsnO8-family-LLM-class-oxidoreductase
MLDIPLSALEVAMVQTGTRAVDTLRDTAAFAQGMERLGYRRLWYAEHHHSPAIGAFPPVVLTAHAAASTSVIRLGSGGVLAPNHAPLTVAEQFGTLAALHEDRIDLGIGRGPGTFDEAIARALRRGAGPATDAEYRRDVAAVLSFLVEEVALGPLPEPWLLVSSAAGAALAAALGLPVAVAHHIRPDNTLAVVEGYRAAFTASRWCERPRVMLCVETVCAPTREEAVWRAGPMNVVKAGLLKGLSQVPFPTPAQAAAHPFTGQERQALDGFRAQQAVGAPEAVVERLARLAGETGAQELMLATPVYDLGARIASYELVRKYWGAAGSS
>NZ_CP018870.1|WP_030031414.1|7410242_7410725_-|lamin-tail-domain-containing-protein
MSASRATRRTLAALLAAGTLLGAAALPAAADDHRRGGHRGPHSSLSIGDVRYESGPRHDRSNRALNREWVEIRNTGRHSVNLRGFTLTDQQGNRYRFPDFRLDGRSAVKVHTGQGRDTRHDLYQDRNRQIWNDRDTATLRDQRGNVIDTESWGRRGHHRG
>NZ_CP018870.1|WP_030031413.1|7409753_7409966_-|hypothetical-protein
MATDAVGRFLAALEPHRRDAVAARPRQEQERLAAAWEEELGSDDELDTLDELSPPAAEAEAARRVMDRES
>NZ_CP018870.1|WP_075969561.1|7408968_7409532_-|GNAT-family-N-acetyltransferase
MRGVRDRLEVSPGLRLRRWSPADAGAVLAAFAEPVMARQAAEPGVTPAAARRWLEARAEQWDAGSGYAFAVVDAADVVLGHVAVGSVERRHGTGWVSYWTTAAARGRGVASGGCRAVAAWAFEDAGLFRLELGHRVDNPASCRVARAAGFAVEGLQRRRLRYDGVRYDVELHARLATDPAPATRPGG
>NZ_CP018870.1|WP_030033911.1|7407870_7408350_+|diadenosine-tetraphosphate-hydrolase
MTGDWRTDRIGTALRGENPTVLRRLTSGFAVIGDVQFLPGYSVLLVDDPQVQRLSDLPKAKRLSFLSDMDQLGEAVERACRRLDPAFRRVNLEILGNKDPFLHAHVWPRFAWEPADAVRAPVWLYPRDRWSDEQSRLGPQHDPLREAIGSELDRLRPTA
>NZ_CP018870.1|WP_075969562.1|7406266_7407847_+|hypothetical-protein
MSTTAAEDEDLVTPSPPTGPHTGPRPLLRTLPTAAAATLATAAGALVAVGCFLGLYIRPTSDDWCAAWKTRDLGVLGITADFYTTQNGRIANAFLSGLLYGGGPAGTKILPTLITLALTAALVLLGRRLLHALGHTPPLLALTACALALQALLYFAGTRSYQVLLWAPATISHTVPSVIGLWALLLALATAAHPRPAVRTAGLAGALLTGFALGTLSEPFALVSALLAALTALLCLPRLHLTTTWRPFTWCLLWCAGLACGLTVLHTSPGARWRRAQQPEKPPILSTGELRATFEDWLRIWDTVTGQWAYLAAAAAGLLLGLAATLRTPRPAPRRVPASGARPGAGRATRTALLLLPLPVVILGSFAVAAGLRSGYGPTGWTYARTWTSFLLPMELALCGYGALLGAWAGPRLAARRPAAAATATTAALCLTLAATASLVPHLQQLTTTTVARSIAWDAQNTRIRTEAAHGATDVGYRPLPIGHLAEPFFTADYDRDWVAACVSRWYGVDRIHRLTGRGGAGTPGP
>NZ_CP018870.1|WP_159393494.1|7404545_7405934_-|glycoside-hydrolase-family-15
MPVVLGCWAVAAAVLAGASVPVCGAGGHAPLSGFTAPTVGVLSNVTAAEGVSASRAAGARYVEGSNVLRLASGRWLYLPAGRTVSVVVGAGDAGALRQIGQSRAWLASGRIPGRSAAERAAAARALLAMRALLRPNGAMAAGWSPGWMYSWPRDASFACAAFAHTGHDAEAFGILRHSAATQRGDGSWEARTKLDGSGPPDGRRWQLDANGWVPWSVWQWYRAAPAEGRRARLATLYPMVARAADRAARSLGADGLPPASPDYWELMTSSTNIGTAAPLLAGLNASADLAREAGRPGDAARWARAARRLSAGISKRFLPLGYQRTVDGRHGRDSAVAFMTPPFNAAPAGLEAVLESTWRALRLPNGGLTPGDDPGAPWGATAWTPSTAFFALAWAAGGRPAKAGPVLEWVLSKRNALGELPEKVDSAGRAASVAPLAWTGSIVLLSLVALESGGLPAPPPGR
>NZ_CP018870.1|WP_075969558.1|7418557_7419205_-|hypothetical-protein
MSDPRPREERRPAAPGAGAGDDTPGQAGVIGIGLAAVLTFALAQGSWQWFATYIGVTLFAVVFAFQVRPAWRPGVRTAYMRALVAYALVVGLCVAIAVAPVLQRGDWLFPMPGTRSRCGEIGRYEVLRTRAAVAGLPGGGAVPASVRESRREEAVADCLASTTTLWLPLYGAGAAVLVGAGAWYRDRNRAGRRPRAGSGPRQPADAAAGPGPGPA
>NZ_CP018870.1|WP_030033448.1|7419519_7419978_+|hypothetical-protein
MFRSTSRKQRFAMYAVSAAIVGGGVLVPTSAFAAPAAAGTTSVAAQAKSGHESDHKKEKWEKKDKKHDKGKKHQKHDKGKKHGKGKKNKVRDVENMPGCKFYQGKVYCEHKPDKPAPAPAPAPNTNPADKENPDKVPAKPNPAPPSAPKAAS
>NZ_CP018870.1|WP_030033937.1|7420215_7421121_-|allantoinase-PuuE
MSELQRDLVGYGAEPPHAAWPGGARVAVSLVLNYEEGGEQNVLEGDAASEGYLHEIVGAPPVRGGRDLNAESMFAYGARAGFWRIHRTLAAYGAPLTVFAVGQALERNPQAARAMGAAGWEVAGHGRRWIDYRQVPEEVERADIAETAAVIGRLVGRRPVGWYTGRTSANTRRLVAGGGFLYDSDDYSDDLPFYAETGGRPHLVVPYSLDANDFKFLIVHGFTTADDMLAYLVDTFETLWAEGGERPRMMSVGMHCRIIGRPGRIRALDGFLRHLEQRGGAWLATREEIARHWLSAHPPVR
>NZ_CP018870.1|WP_030032619.1|7421253_7421538_+|DUF3253-domain-containing-protein
MTGGNRQTDRQTDRQLERAILELLRRRAPTATICPSDAARAVYEGDGDGWRALMEPARRAARRLVAAGKVEITQGGRRVDPAKARGPIRIRRTP
>NZ_CP018870.1|WP_045324329.1|7421962_7422406_+|transglycosylase-SLT-domain-containing-protein
MPRPPLSPVEGISVSNTVIRRIAASKKALAGTVVALGVAGSMLAAVPAQAAPTSAKAIAQQMIKDPAQFAAFNNIVSRESGWNHTATNASSGAYGLVQALPASKMASAGADWKTNPATQIKWGLDYMNERYGSPVGAWNFWQTHHWY
>NZ_CP018870.1|WP_051873430.1|7422547_7422928_-|STAS-domain-containing-protein
MAEHPDRETGAKTGAEPVVEIVGRVVAVRPAGEIDIVTAPFLTRALTRALAHVDAAQADRIVTDCSRVTFCDSSGLNALLAARLRAVEAGTAIHLADPAPQLQRLLQMTGAAPLFPREDGPPARPA
>NZ_CP018870.1|WP_075971917.1|7422981_7423674_-|HSP18-transcriptional-regulator
MNETSPPVPPVRAPDAAAALQAIHRAVEDAHRASGGAEADTADTAGAAAGAAAGGGGPEQALEALRRLREVRERITGWESVLIETARGQGVSWAELAGPLGVASRQAAERRYLRLRPGAAGSTGEQRVQATRDARAADRSVTAWARDNAADLRRLAGQVTSLTGLPPGAEGAVGELNLALGGDDAARLVGPLAGTRPHLGPGDAELADRIDAMTRHADRLRRDSNDQRNS
>NZ_CP018870.1|WP_030032938.1|7423833_7424268_+|Hsp20/alpha-crystallin-family-protein
MLMRTDPFREMDRIVQQLSGASGTWSKPSVMPMDAYREDDVYVIAFDLPGVSTEAIDIDVERNMLTVKAERRPVAKGDTVQMELSERPLGVFSRQLMLADTLDTERIEADYDAGVLTLRIPIAERAKPRKIAIGGESGRKQISG
>NZ_CP018870.1|WP_030032941.1|7424409_7424805_+|DUF2267-domain-containing-protein
MPMRPDAFLDHVRESGEYPTRAEAERAARVVLALLGAHLVGTVRAELAARLPETYALILLNPLQAAEPLSPERFVRATAAWIEGATEKTALWDIGAVLSTVADAAGDTLTREILLQLPVGYDVLFGHPRPT
>NZ_CP018870.1|WP_030032943.1|7424873_7425320_+|DUF2267-domain-containing-protein
MYDQPRPNQAPPAMTFDRMLERVRYEGAYPTAERAEEAVRAVLAALGRQVTGDERVDLAQALPVEAALALTAQIPGVEQLTGWGFVKDLAARTGTTPAIARWDTGAVLAVVARLAGPDLLARILNRLPDGYALLFGQAQLRRPEPAAA

Crispr_ID: NZ_CP018870_22

• CRISPR_ID: NZ_CP018870_22
• CRISPR_location: 7564152-7564238
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP018870_22

Consensus_repeat	Method
CCTACGACCCGGCGGGCCGGCTC	CRISPRCasFinder

spacers of NZ_CP018870_22

>22.1|7564175|40|NZ_CP018870|CRISPRCasFinder
ATCCGGGAGACCGACTTCGACGGCCGTGTGCTCGACTACG

CRISPR arrays and Neighbor proteins around NZ_CP018870_22

CRISPR arrays

The CRISPR arrays of NZ_CP018870_22

>merge|NZ_CP018870|22|7564152-7564238|CRISPRCasFinder
CCTACGACCCGGCGGGCCGGCTCATCCGGGAGACCGACTTCGACGGCCGTGTGCTCGACTACGCCTACGACCCGGCGGGCCGGCTCG

>NZ_CP018870|22|20|7564152-7564238|CRISPRCasFinder
CCTACGACCCGGCGGGCCGGCTC	ATCCGGGAGACCGACTTCGACGGCCGTGTGCTCGACTACG
CCTACGACCCGGCGGGCCGGCTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_075969486.1|7558553_7559108_+|DNA-binding-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969474.1|7573040_7573307_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_159393485.1|7548653_7549214_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969491.1|7549727_7550021_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_079273399.1|7554664_7555297_+|VCBS-repeat-containing-protein	unknown	unknown	gnl|CDD|379232
NZ_CP018870.1|WP_079273053.1|7559403_7559634_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_159393484.1|7550191_7550410_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969482.1|7566002_7566761_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969476.1|7572224_7572545_+|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NZ_CP018870.1|WP_075969473.1|7574719_7576837_-|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl|CDD|366234
NZ_CP018870.1|WP_075969480.1|7567319_7567613_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969484.1|7560797_7561355_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075971905.1|7560384_7560798_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969478.1|7568927_7569542_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969472.1|7576833_7577592_-|TnsA-like-heteromeric-transposase-endonuclease-subunit	unknown	unknown	gnl|CDD|380186
NZ_CP018870.1|WP_159393482.1|7569596_7572035_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_CP018870.1|WP_075969493.1|7548033_7548237_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_159393483.1|7551135_7552773_+|phospholipase	unknown	unknown	gnl|CDD|370266
NZ_CP018870.1|WP_157879710.1|7572550_7572862_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075971904.1|7573667_7574636_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|377533

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_075969472.1|7576833_7577592_-|TnsA-like-heteromeric-transposase-endonuclease-subunit	gnl|CDD|380186	NF033179, TnsA_like_Actin, TnsA-like heteromeric transposase endonuclease subunit. The transposase of transposon Tn7 contains multiple subunit. Members of this family are largely restricted to the Actinobacteria, resemble the endonuclease subunit TsnA of the multimeric transposase of Tn7 and its relatives, and occur in genomic neighborhoods that suggest a similar role in transposition.	2.58893e-100
NZ_CP018870.1|WP_075969473.1|7574719_7576837_-|DDE-type-integrase/transposase/recombinase	gnl|CDD|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	4.56322e-12
NZ_CP018870.1|WP_079273399.1|7554664_7555297_+|VCBS-repeat-containing-protein	gnl|CDD|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	4.30212e-07
NZ_CP018870.1|WP_159393482.1|7569596_7572035_-|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.3573e-105
NZ_CP018870.1|WP_075969476.1|7572224_7572545_+|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00316607
NZ_CP018870.1|WP_159393483.1|7551135_7552773_+|phospholipase	gnl|CDD|370266	pfam09056, Phospholip_A2_3, Prokaryotic phospholipase A2. The prokaryotic phospholipase A2 domain is predominantly found in bacterial and fungal phospholipases, as well as various hypothetical and putative proteins. It enables the liberation of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides. The domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments.	1.18523e-11
NZ_CP018870.1|WP_075971904.1|7573667_7574636_-|AAA-family-ATPase	gnl|CDD|377533	pfam05621, TniB, Bacterial TniB protein. This family consists of several bacterial TniB NTP-binding proteins. TniB is a probable ATP-binding protein which is involved in Tn5053 mercury resistance transposition.	6.96978e-10

Protein sequences

>NZ_CP018870.1|WP_075969484.1|7560797_7561355_+|hypothetical-protein
MAGDADLEVSPAAVKNIQDGLRRAVAELRESGDAAGASMGAGFSDLSMTGMEAGHAGLATDFEDFCERWEWGVRSLVQNASALAGNLGIAAGTVWEEEHYMQGAFKVVANAAYGNPHASEDEIEQKSWDDIWRADVYKPDYSDESFEKSDADIKQTWSDTGDKLTSSGKIGSLKDLLDQAGGGGN
>NZ_CP018870.1|WP_075971905.1|7560384_7560798_+|hypothetical-protein
MGLAEEISAVRSVSGHSGRLLGEFRRAALLVPLSEGDGGGLMSGWQGGVRWIYAFTDEEALARFAVARGADAGAREWEYLSILGARLVDAVIPTVEGPTGVAVDVADEDGSMLFPPVVGIVPDAYAVDAGPDRAEAV
>NZ_CP018870.1|WP_079273053.1|7559403_7559634_-|hypothetical-protein
MAAGGKRLSVHLADQDDKILVMALNHQTREQDAAGAVPAGVAVLRTVDACGAHTDHDGHAWWALLDARPAPKKRLA
>NZ_CP018870.1|WP_075969486.1|7558553_7559108_+|DNA-binding-protein
MGEIEDAILRADQEAFTKDPPKTLKGQINFLLKQLKTTRAVAAELGVSQRSVERYRKGDRKTPPQPVATRIEAAVRARWQPVVRGRRRKEAATSTGITVETRARFGYTAPVGTTDDGRVRRLTVHLPPAYAQRLFDARARGADDRDLRGIVAEGLQEIYFKDGGTRADELRVEFTDIDYFDVSF
>NZ_CP018870.1|WP_079273399.1|7554664_7555297_+|VCBS-repeat-containing-protein
MTHRGDWTGDAKEDIVARVGGELRVYPNRGDGTLGAHIKIGSGLPTTAQVVGAGDVTKDGHPDLLVQHSNKLYLYAGAAGPAPSVAAPVIIGTSGWDVMDLTAPGDADHDGRVDLLARDTRDGILYHYLGQPDGKTFSDRTEYGRGYTNAFRPLIAGAADANRDGIADMWATAADGTLKFYKGDTSIHGPVDGPSIQVGSGGWGAIKSIS
>NZ_CP018870.1|WP_159393483.1|7551135_7552773_+|phospholipase
MVSLSLLLPQQMAGATPAAASPAAGSAVVDPPLADGQVQQVGPGVYSTADKSFEIYETDVAVGLMSRSHTVTVQPDGVSRPESAPVARADMGIFGPGWEAEFVGGQLNRKLEQSGNTAVVTDLTMNAAATYALKSSLDFPDGGGVRKYATPEGDTLTETTRFNEATGTMVSTAVESANAATSLPDEDLSADADATAPSNFAQLAPTYTWKQVGTGANSWRVTGVGTAANSALSTVTYDTAGRVATVKDAEIGETTSRLLTVKYSTATTATGTTPGEFTGRAREITLTDGATVQTLARYSYDATGRLRSVANPAEGIDAASSYSYDTTGRVSAVASPANGNWELTFPAGSASPNVEPVGPARPAADAPLEGAGGITDPAAGPLPTDFINGEITDPQAYPRHCSAATDWLWYLKRNCAAWAAHYGWHKPTFKTTPTNHRVVGINYDGCSTPGPNVSRPGGFNFRTACDMHDYGYGLIGNTYKGYSYYLDRSKKSNVENAFHTTMKTYSCKAYFILRRPGCNNWAYAYYKAVSNQRWGGNPKNGADAT
>NZ_CP018870.1|WP_159393484.1|7550191_7550410_+|hypothetical-protein
MPIRRVRVVAVSAAVVAMAAVAGWDPAALLGRSKAKEAVVRVDQSGYVTGEVKVAAVMGDEEALAGAGFVVP
>NZ_CP018870.1|WP_075969491.1|7549727_7550021_-|hypothetical-protein
MINLHVRGESGTIEARAKHGVLWGPELAGLDQAVFPMLGHLLPYGDTVFNHRQVSTLLEEVPRLPAGVLTDEFARELIELGQVVLAGQGLYLWFLGD
>NZ_CP018870.1|WP_159393485.1|7548653_7549214_+|hypothetical-protein
MDAAVREAAVARFLREYPLMEQAACDHPALLGCADVDWSQIPGCPAGVPVLLRGLLDEVAGPAALTVLENVLMNSVFHVSAVMPAVLPFLIRLAAVPDIAVRSGLVDFLVVAAELSSSVDADDERQVLLFGKDSDHPEREWCRAAFAAHASALRALLEDGTLPDGLISADDRECLLRAVEPQRRPS
>NZ_CP018870.1|WP_075969493.1|7548033_7548237_+|hypothetical-protein
MAHRSDRTGDAKKDIVPRVGGELRVYRVVGAGDVTKDGHPDLLVQHSNKLYLYASIAMRRAAVGTRS
>NZ_CP018870.1|WP_075969482.1|7566002_7566761_+|hypothetical-protein
MSSRSGIPRDPAPGWPGYHAEPSYDPGQSRVFPAPLPAELRALGNDVRAADWPVRLAFRNSRTELLDTLCRWQTLRALAYVHLLAARTGDERLPADLRVVPDPEAVGEPGLPALLARLEHAAAGLPADLLDAVVCDSGGLLADNRFAASVLAAGLTADSRPGDPDKAVSRAVVLTSYWYEVPGLRGALALAWSANLFVRSWLGWSQRFVYGDPAGGLGITSDPRPPRPAASALPKWAEPLLDRIEQGPGAAS
>NZ_CP018870.1|WP_075969480.1|7567319_7567613_+|hypothetical-protein
MEMVERLPFGMRTAVEATYVRCALCGAFGELVLDSGRLDEALARARDHVRETHPGADIPEALRLVPDVAFPPDGCRDVVEWVEQYNARNTLPVPGPR
>NZ_CP018870.1|WP_075969478.1|7568927_7569542_+|hypothetical-protein
MHPEFDRADVVNWLLAHDKITLPAGAGQASLLVRGERGATGRFRLDAPWLGLADDIEGTDRLSGWVADDADADALAALAAGPVGATLTRLTAPGAGPLAVLGDVRVTDRLWSGSGGLRITLEWPARLRGTTAHTGNGGVVATASRRPGPARTACAPATTAAAWTQSCGATNTAARRPPVLDWHAGGGLRCAQLGRGSVASVTSA
>NZ_CP018870.1|WP_159393482.1|7569596_7572035_-|tetratricopeptide-repeat-protein
MGEVWAASDLRLRRTVAVKTVLISHLRDERLAAQVLARFRREGEAAARLNHRNIAVVHDLGEHRETSADGQVEVSPFLVMEFLEGRDLATVLREDHPGGLPLEQVVEYGAQVCDGLAAAHTQNIVHRDIKPANLMLLDDGTVKICDFGIAQVQDGTIGLTMTGALLGSPHYMAPEQLRGQTPTHSADLYALGASLYELLTGRPLFTADSAYAIIAMHLSTTPEPPSTRQPAIPPDIDNLITSLIAKDPAGRPPTAKDVAARLRTAHLAPGPTPVPAAEASETDEQLLQRDAEAGDSDAMYSLAWLLQEADRIDEAETWYRKAADAGQIDAMNNLGVLLENTGRTNEAETWYRKAADAGQIDARNNLGVLLENTGRTDEAETWYRKAADAGNTDAMNNLGLLLENTGRTDEAETWYRKAADTGDTDAMYSLGVVLAGTGRTDEAETWYRKAADTGHTDAMTNLGVVLAYSGRTDEAETWYRKAADAGQMNATANLGVVLAGTGRTNEAETWYRKATDAGNTDAMHGLGVLLANTGRTDEAETWYRKAIDAGNTDAMNDLGALLHNTGRETEAQPWFQRAAEAGHTNAMNNLALLLHNTGRETEAEPWYRRAVDAGNTNAMNNLALLLENTGRETEAEPWYQRAVDAGNTNAMNNLGMVLEDAGRTNEAETWYRKATDAGNTGAMTNLGLLLENTGRTNEAETWYRKATDAGQIKAMNNLGVLLQTTGRETEAEPWYQRAADAGNTEAMNNLGVVLQGTGRTAEAETWYRRAAEAGNAPAMNNLARLLQNTGRAAEAETWYQRAAGNPDGEIRA
>NZ_CP018870.1|WP_075969476.1|7572224_7572545_+|hypothetical-protein
MQQLGEHHGTDTVAQHLNRLTTATSWQEATGSALVGRLVDATLTSLTTPPGAPAPSRPRVSAAAARSRSTTTPTAAAAPGRPAPAEAAVPTHRQQAAPVRGAGRRR
>NZ_CP018870.1|WP_157879710.1|7572550_7572862_+|hypothetical-protein
MTGRQRRAGGSALAGLVLATAGWWAQWSGYEVVGTALTLLAGTVVLAGAWRSGVLHLPQHEAGRQATQQQRARDSGCRCSEGSSSCAPCSVLYGPLHLLATLL
>NZ_CP018870.1|WP_075969474.1|7573040_7573307_+|hypothetical-protein
MRFFSVKGREYVALTVLGSDDFDALEVVEMTAAGRGALLLEFRMDEETATLVHLGAEVGIPLLRASLEIFRTDFLEPRRAAGLPLRPW
>NZ_CP018870.1|WP_075971904.1|7573667_7574636_-|AAA-family-ATPase
MTTWQGWQRFATTDPVAPPQPGDPPRSTEERLAYHSSFVTIRTPAIHTLTTQVRTLMILGRHQQNTARPSLIVTGPAAAGKTTALLNVGRTCHLAHTRKNPAPPGSAHTAVPVAYVLVPPGATAKTLVTEFARYLGIPVTARMTQTQITDAVCHTYTQAGVQLVMIDEIHRLNPRTTTGAQTADLLKDLSERLPATFVYAGINVTDTPLFSGTRGAQLAGRATLVDCGPLPARHGTRQPFRDAITDIENNLDLQQHKAGTLPAHAPYLHQRTAGRIGSLTRLIRQAAITAICDGTERITKTALDAVRLDHLAETHHRPHRRR
>NZ_CP018870.1|WP_075969473.1|7574719_7576837_-|DDE-type-integrase/transposase/recombinase
MSARRTARPAVAVGAHVRFRGVKWQVVALSGQMVHLVGPDGGGEAVLAGYLFADPGFSVIGAEVPQAAPQWGLFETAPAAAREKALAWQRHVREVECGLADGPGSGGVVREQYDPARHTLAEREQAKAEELTALGFGRVSRTTVQRMRLAYRKQGLWGLLDHRTTRASSSTGRSDERVVAAVREALRRRRGRSRGTINGLFPLIHQILQDRHGPGAVPVPSQATLYRLVTSLARPGELPSGPVRQVPASVEGRAFTPATALRPGEQVQIDTTRLDVLALFDDGRLARPELTIAVDVATRAILAAVLCPSATKSVDAALLLAEMAVPHPARPTWPDILRMDHARALPYQQLATLDERLAGAAARPVVLPETIVVDRGKVFVSAAFTAACETLGISVQPAPPRAPTAKGIVERTFGSINALFCQHLPGYTGSDVTRRGPEAEKDACFSVAQLQDLLDEWLVHYHHRPHEGLRHPMMPRKALTPNEMWGALVAVAGYVPVPLTGRDYLELLPVRWQAITPAGITIRHRTYDADLLAPHRGQASPVAGRGGKWEIHYNPHDVRQIWIRLPDGELTEIPWIHRDHVHRPFDEHTWQHIRTQATDCNHGDAEQHEARLADALDQLMRRVHSGHATKTEQTLLARTAHVPLPTARNGAHGTEAPADSPEQRDDDTIDDLDDLDGLDDLPDDVSPAPATGLGLYNAHEEADKW
>NZ_CP018870.1|WP_075969472.1|7576833_7577592_-|TnsA-like-heteromeric-transposase-endonuclease-subunit
MDSGSGFEAVFLDPVGQSVQQRWADAAMTVAFEELPPVSAFPVVPGRRWGPGLWWSATTGRHVAAGSNAMRTQLMALDRDPRVTGLAGRPVRLLWRDERGRVRSWVPQLFARYRDGTGLLADCPSHPDAGGERALGAAHAVARACGDIGWAYRRLSPLDDVPASNLKWLAGYRHPRNAGRPGLTPAAVEAFARPRPLIEGAEAVGDPIEVLPVVFHALWHGQLTTDLEAPLHECVPVGPRDWNGLGRTGGAG

Crispr_ID: NZ_CP018870_23

• CRISPR_ID: NZ_CP018870_23
• CRISPR_location: 7564458-7564603
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP018870_23

Consensus_repeat	Method
CCTACGACCCGGCGGGCCGGCTC	CRISPRCasFinder

spacers of NZ_CP018870_23

>23.1|7564481|40|NZ_CP018870|CRISPRCasFinder
ACCGGCCGAACCACCCCCACGGGCGCCGTCGCCGCCTGGG
>23.2|7564544|37|NZ_CP018870|CRISPRCasFinder
GACGCCCTGACCACGTCCGGCCGCCGGATCGGCTTCA

CRISPR arrays and Neighbor proteins around NZ_CP018870_23

CRISPR arrays

The CRISPR arrays of NZ_CP018870_23

>merge|NZ_CP018870|23|7564458-7564603|CRISPRCasFinder
CCTACGACGCCATGGGGCGCCGCACCGGCCGAACCACCCCCACGGGCGCCGTCGCCGCCTGGGCGTACGACGCCGCAGGCCGCTACGACGCCCTGACCACGTCCGGCCGCCGGATCGGCTTCACGCACGACGCGGCGGGCCAGGAG

>NZ_CP018870|23|21|7564458-7564603|CRISPRCasFinder
CCTACGACGCCATGGGGCGCCGC	ACCGGCCGAACCACCCCCACGGGCGCCGTCGCCGCCTGGG
CGTACGACGCCGCAGGCCGCTAC	GACGCCCTGACCACGTCCGGCCGCCGGATCGGCTTCA
CGCACGACGCGGCGGGCCAGGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP018870.1|WP_075969486.1|7558553_7559108_+|DNA-binding-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969474.1|7573040_7573307_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_159393485.1|7548653_7549214_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969491.1|7549727_7550021_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_079273399.1|7554664_7555297_+|VCBS-repeat-containing-protein	unknown	unknown	gnl|CDD|379232
NZ_CP018870.1|WP_079273053.1|7559403_7559634_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_159393484.1|7550191_7550410_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969482.1|7566002_7566761_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969476.1|7572224_7572545_+|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NZ_CP018870.1|WP_075969473.1|7574719_7576837_-|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl|CDD|366234
NZ_CP018870.1|WP_075969480.1|7567319_7567613_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969484.1|7560797_7561355_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075971905.1|7560384_7560798_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969478.1|7568927_7569542_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075969472.1|7576833_7577592_-|TnsA-like-heteromeric-transposase-endonuclease-subunit	unknown	unknown	gnl|CDD|380186
NZ_CP018870.1|WP_159393482.1|7569596_7572035_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_CP018870.1|WP_075969493.1|7548033_7548237_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_159393483.1|7551135_7552773_+|phospholipase	unknown	unknown	gnl|CDD|370266
NZ_CP018870.1|WP_157879710.1|7572550_7572862_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP018870.1|WP_075971904.1|7573667_7574636_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|377533

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP018870.1|WP_075969472.1|7576833_7577592_-|TnsA-like-heteromeric-transposase-endonuclease-subunit	gnl|CDD|380186	NF033179, TnsA_like_Actin, TnsA-like heteromeric transposase endonuclease subunit. The transposase of transposon Tn7 contains multiple subunit. Members of this family are largely restricted to the Actinobacteria, resemble the endonuclease subunit TsnA of the multimeric transposase of Tn7 and its relatives, and occur in genomic neighborhoods that suggest a similar role in transposition.	2.58893e-100
NZ_CP018870.1|WP_075969473.1|7574719_7576837_-|DDE-type-integrase/transposase/recombinase	gnl|CDD|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	4.56322e-12
NZ_CP018870.1|WP_079273399.1|7554664_7555297_+|VCBS-repeat-containing-protein	gnl|CDD|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	4.30212e-07
NZ_CP018870.1|WP_159393482.1|7569596_7572035_-|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.3573e-105
NZ_CP018870.1|WP_075969476.1|7572224_7572545_+|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00316607
NZ_CP018870.1|WP_159393483.1|7551135_7552773_+|phospholipase	gnl|CDD|370266	pfam09056, Phospholip_A2_3, Prokaryotic phospholipase A2. The prokaryotic phospholipase A2 domain is predominantly found in bacterial and fungal phospholipases, as well as various hypothetical and putative proteins. It enables the liberation of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides. The domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments.	1.18523e-11
NZ_CP018870.1|WP_075971904.1|7573667_7574636_-|AAA-family-ATPase	gnl|CDD|377533	pfam05621, TniB, Bacterial TniB protein. This family consists of several bacterial TniB NTP-binding proteins. TniB is a probable ATP-binding protein which is involved in Tn5053 mercury resistance transposition.	6.96978e-10

Protein sequences

>NZ_CP018870.1|WP_075969484.1|7560797_7561355_+|hypothetical-protein
MAGDADLEVSPAAVKNIQDGLRRAVAELRESGDAAGASMGAGFSDLSMTGMEAGHAGLATDFEDFCERWEWGVRSLVQNASALAGNLGIAAGTVWEEEHYMQGAFKVVANAAYGNPHASEDEIEQKSWDDIWRADVYKPDYSDESFEKSDADIKQTWSDTGDKLTSSGKIGSLKDLLDQAGGGGN
>NZ_CP018870.1|WP_075971905.1|7560384_7560798_+|hypothetical-protein
MGLAEEISAVRSVSGHSGRLLGEFRRAALLVPLSEGDGGGLMSGWQGGVRWIYAFTDEEALARFAVARGADAGAREWEYLSILGARLVDAVIPTVEGPTGVAVDVADEDGSMLFPPVVGIVPDAYAVDAGPDRAEAV
>NZ_CP018870.1|WP_079273053.1|7559403_7559634_-|hypothetical-protein
MAAGGKRLSVHLADQDDKILVMALNHQTREQDAAGAVPAGVAVLRTVDACGAHTDHDGHAWWALLDARPAPKKRLA
>NZ_CP018870.1|WP_075969486.1|7558553_7559108_+|DNA-binding-protein
MGEIEDAILRADQEAFTKDPPKTLKGQINFLLKQLKTTRAVAAELGVSQRSVERYRKGDRKTPPQPVATRIEAAVRARWQPVVRGRRRKEAATSTGITVETRARFGYTAPVGTTDDGRVRRLTVHLPPAYAQRLFDARARGADDRDLRGIVAEGLQEIYFKDGGTRADELRVEFTDIDYFDVSF
>NZ_CP018870.1|WP_079273399.1|7554664_7555297_+|VCBS-repeat-containing-protein
MTHRGDWTGDAKEDIVARVGGELRVYPNRGDGTLGAHIKIGSGLPTTAQVVGAGDVTKDGHPDLLVQHSNKLYLYAGAAGPAPSVAAPVIIGTSGWDVMDLTAPGDADHDGRVDLLARDTRDGILYHYLGQPDGKTFSDRTEYGRGYTNAFRPLIAGAADANRDGIADMWATAADGTLKFYKGDTSIHGPVDGPSIQVGSGGWGAIKSIS
>NZ_CP018870.1|WP_159393483.1|7551135_7552773_+|phospholipase
MVSLSLLLPQQMAGATPAAASPAAGSAVVDPPLADGQVQQVGPGVYSTADKSFEIYETDVAVGLMSRSHTVTVQPDGVSRPESAPVARADMGIFGPGWEAEFVGGQLNRKLEQSGNTAVVTDLTMNAAATYALKSSLDFPDGGGVRKYATPEGDTLTETTRFNEATGTMVSTAVESANAATSLPDEDLSADADATAPSNFAQLAPTYTWKQVGTGANSWRVTGVGTAANSALSTVTYDTAGRVATVKDAEIGETTSRLLTVKYSTATTATGTTPGEFTGRAREITLTDGATVQTLARYSYDATGRLRSVANPAEGIDAASSYSYDTTGRVSAVASPANGNWELTFPAGSASPNVEPVGPARPAADAPLEGAGGITDPAAGPLPTDFINGEITDPQAYPRHCSAATDWLWYLKRNCAAWAAHYGWHKPTFKTTPTNHRVVGINYDGCSTPGPNVSRPGGFNFRTACDMHDYGYGLIGNTYKGYSYYLDRSKKSNVENAFHTTMKTYSCKAYFILRRPGCNNWAYAYYKAVSNQRWGGNPKNGADAT
>NZ_CP018870.1|WP_159393484.1|7550191_7550410_+|hypothetical-protein
MPIRRVRVVAVSAAVVAMAAVAGWDPAALLGRSKAKEAVVRVDQSGYVTGEVKVAAVMGDEEALAGAGFVVP
>NZ_CP018870.1|WP_075969491.1|7549727_7550021_-|hypothetical-protein
MINLHVRGESGTIEARAKHGVLWGPELAGLDQAVFPMLGHLLPYGDTVFNHRQVSTLLEEVPRLPAGVLTDEFARELIELGQVVLAGQGLYLWFLGD
>NZ_CP018870.1|WP_159393485.1|7548653_7549214_+|hypothetical-protein
MDAAVREAAVARFLREYPLMEQAACDHPALLGCADVDWSQIPGCPAGVPVLLRGLLDEVAGPAALTVLENVLMNSVFHVSAVMPAVLPFLIRLAAVPDIAVRSGLVDFLVVAAELSSSVDADDERQVLLFGKDSDHPEREWCRAAFAAHASALRALLEDGTLPDGLISADDRECLLRAVEPQRRPS
>NZ_CP018870.1|WP_075969493.1|7548033_7548237_+|hypothetical-protein
MAHRSDRTGDAKKDIVPRVGGELRVYRVVGAGDVTKDGHPDLLVQHSNKLYLYASIAMRRAAVGTRS
>NZ_CP018870.1|WP_075969482.1|7566002_7566761_+|hypothetical-protein
MSSRSGIPRDPAPGWPGYHAEPSYDPGQSRVFPAPLPAELRALGNDVRAADWPVRLAFRNSRTELLDTLCRWQTLRALAYVHLLAARTGDERLPADLRVVPDPEAVGEPGLPALLARLEHAAAGLPADLLDAVVCDSGGLLADNRFAASVLAAGLTADSRPGDPDKAVSRAVVLTSYWYEVPGLRGALALAWSANLFVRSWLGWSQRFVYGDPAGGLGITSDPRPPRPAASALPKWAEPLLDRIEQGPGAAS
>NZ_CP018870.1|WP_075969480.1|7567319_7567613_+|hypothetical-protein
MEMVERLPFGMRTAVEATYVRCALCGAFGELVLDSGRLDEALARARDHVRETHPGADIPEALRLVPDVAFPPDGCRDVVEWVEQYNARNTLPVPGPR
>NZ_CP018870.1|WP_075969478.1|7568927_7569542_+|hypothetical-protein
MHPEFDRADVVNWLLAHDKITLPAGAGQASLLVRGERGATGRFRLDAPWLGLADDIEGTDRLSGWVADDADADALAALAAGPVGATLTRLTAPGAGPLAVLGDVRVTDRLWSGSGGLRITLEWPARLRGTTAHTGNGGVVATASRRPGPARTACAPATTAAAWTQSCGATNTAARRPPVLDWHAGGGLRCAQLGRGSVASVTSA
>NZ_CP018870.1|WP_159393482.1|7569596_7572035_-|tetratricopeptide-repeat-protein
MGEVWAASDLRLRRTVAVKTVLISHLRDERLAAQVLARFRREGEAAARLNHRNIAVVHDLGEHRETSADGQVEVSPFLVMEFLEGRDLATVLREDHPGGLPLEQVVEYGAQVCDGLAAAHTQNIVHRDIKPANLMLLDDGTVKICDFGIAQVQDGTIGLTMTGALLGSPHYMAPEQLRGQTPTHSADLYALGASLYELLTGRPLFTADSAYAIIAMHLSTTPEPPSTRQPAIPPDIDNLITSLIAKDPAGRPPTAKDVAARLRTAHLAPGPTPVPAAEASETDEQLLQRDAEAGDSDAMYSLAWLLQEADRIDEAETWYRKAADAGQIDAMNNLGVLLENTGRTNEAETWYRKAADAGQIDARNNLGVLLENTGRTDEAETWYRKAADAGNTDAMNNLGLLLENTGRTDEAETWYRKAADTGDTDAMYSLGVVLAGTGRTDEAETWYRKAADTGHTDAMTNLGVVLAYSGRTDEAETWYRKAADAGQMNATANLGVVLAGTGRTNEAETWYRKATDAGNTDAMHGLGVLLANTGRTDEAETWYRKAIDAGNTDAMNDLGALLHNTGRETEAQPWFQRAAEAGHTNAMNNLALLLHNTGRETEAEPWYRRAVDAGNTNAMNNLALLLENTGRETEAEPWYQRAVDAGNTNAMNNLGMVLEDAGRTNEAETWYRKATDAGNTGAMTNLGLLLENTGRTNEAETWYRKATDAGQIKAMNNLGVLLQTTGRETEAEPWYQRAADAGNTEAMNNLGVVLQGTGRTAEAETWYRRAAEAGNAPAMNNLARLLQNTGRAAEAETWYQRAAGNPDGEIRA
>NZ_CP018870.1|WP_075969476.1|7572224_7572545_+|hypothetical-protein
MQQLGEHHGTDTVAQHLNRLTTATSWQEATGSALVGRLVDATLTSLTTPPGAPAPSRPRVSAAAARSRSTTTPTAAAAPGRPAPAEAAVPTHRQQAAPVRGAGRRR
>NZ_CP018870.1|WP_157879710.1|7572550_7572862_+|hypothetical-protein
MTGRQRRAGGSALAGLVLATAGWWAQWSGYEVVGTALTLLAGTVVLAGAWRSGVLHLPQHEAGRQATQQQRARDSGCRCSEGSSSCAPCSVLYGPLHLLATLL
>NZ_CP018870.1|WP_075969474.1|7573040_7573307_+|hypothetical-protein
MRFFSVKGREYVALTVLGSDDFDALEVVEMTAAGRGALLLEFRMDEETATLVHLGAEVGIPLLRASLEIFRTDFLEPRRAAGLPLRPW
>NZ_CP018870.1|WP_075971904.1|7573667_7574636_-|AAA-family-ATPase
MTTWQGWQRFATTDPVAPPQPGDPPRSTEERLAYHSSFVTIRTPAIHTLTTQVRTLMILGRHQQNTARPSLIVTGPAAAGKTTALLNVGRTCHLAHTRKNPAPPGSAHTAVPVAYVLVPPGATAKTLVTEFARYLGIPVTARMTQTQITDAVCHTYTQAGVQLVMIDEIHRLNPRTTTGAQTADLLKDLSERLPATFVYAGINVTDTPLFSGTRGAQLAGRATLVDCGPLPARHGTRQPFRDAITDIENNLDLQQHKAGTLPAHAPYLHQRTAGRIGSLTRLIRQAAITAICDGTERITKTALDAVRLDHLAETHHRPHRRR
>NZ_CP018870.1|WP_075969473.1|7574719_7576837_-|DDE-type-integrase/transposase/recombinase
MSARRTARPAVAVGAHVRFRGVKWQVVALSGQMVHLVGPDGGGEAVLAGYLFADPGFSVIGAEVPQAAPQWGLFETAPAAAREKALAWQRHVREVECGLADGPGSGGVVREQYDPARHTLAEREQAKAEELTALGFGRVSRTTVQRMRLAYRKQGLWGLLDHRTTRASSSTGRSDERVVAAVREALRRRRGRSRGTINGLFPLIHQILQDRHGPGAVPVPSQATLYRLVTSLARPGELPSGPVRQVPASVEGRAFTPATALRPGEQVQIDTTRLDVLALFDDGRLARPELTIAVDVATRAILAAVLCPSATKSVDAALLLAEMAVPHPARPTWPDILRMDHARALPYQQLATLDERLAGAAARPVVLPETIVVDRGKVFVSAAFTAACETLGISVQPAPPRAPTAKGIVERTFGSINALFCQHLPGYTGSDVTRRGPEAEKDACFSVAQLQDLLDEWLVHYHHRPHEGLRHPMMPRKALTPNEMWGALVAVAGYVPVPLTGRDYLELLPVRWQAITPAGITIRHRTYDADLLAPHRGQASPVAGRGGKWEIHYNPHDVRQIWIRLPDGELTEIPWIHRDHVHRPFDEHTWQHIRTQATDCNHGDAEQHEARLADALDQLMRRVHSGHATKTEQTLLARTAHVPLPTARNGAHGTEAPADSPEQRDDDTIDDLDDLDGLDDLPDDVSPAPATGLGLYNAHEEADKW
>NZ_CP018870.1|WP_075969472.1|7576833_7577592_-|TnsA-like-heteromeric-transposase-endonuclease-subunit
MDSGSGFEAVFLDPVGQSVQQRWADAAMTVAFEELPPVSAFPVVPGRRWGPGLWWSATTGRHVAAGSNAMRTQLMALDRDPRVTGLAGRPVRLLWRDERGRVRSWVPQLFARYRDGTGLLADCPSHPDAGGERALGAAHAVARACGDIGWAYRRLSPLDDVPASNLKWLAGYRHPRNAGRPGLTPAAVEAFARPRPLIEGAEAVGDPIEVLPVVFHALWHGQLTTDLEAPLHECVPVGPRDWNGLGRTGGAG

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP018870_3	3.1|1698887|21|NZ_CP018870|CRT	1698887-1698907	21	NZ_CP018870.1	1698668-1698688	0	1.0
NZ_CP018870_3	3.2|1698926|18|NZ_CP018870|CRT	1698926-1698943	18	NZ_CP018870.1	1698707-1698724	0	1.0
NZ_CP018870_3	3.3|1698962|18|NZ_CP018870|CRT	1698962-1698979	18	NZ_CP018870.1	1698377-1698394	0	1.0
NZ_CP018870_3	3.3|1698962|18|NZ_CP018870|CRT	1698962-1698979	18	NZ_CP018870.1	1698743-1698760	0	1.0
NZ_CP018870_13	13.1|4195394|40|NZ_CP018870|CRISPRCasFinder	4195394-4195433	40	NZ_CP018870.1	4423581-4423620	0	1.0
NZ_CP018870_22	22.1|7564175|40|NZ_CP018870|CRISPRCasFinder	7564175-7564214	40	NZ_CP018870.1	20821-20860	0	1.0
NZ_CP018870_23	23.1|7564481|40|NZ_CP018870|CRISPRCasFinder	7564481-7564520	40	NZ_CP018870.1	20515-20554	0	1.0
NZ_CP018870_23	23.2|7564544|37|NZ_CP018870|CRISPRCasFinder	7564544-7564580	37	NZ_CP018870.1	20455-20491	0	1.0
NZ_CP018870_3	3.1|1698887|21|NZ_CP018870|CRT	1698887-1698907	21	NZ_CP018870.1	1698251-1698271	1	0.952
NZ_CP018870_3	3.2|1698926|18|NZ_CP018870|CRT	1698926-1698943	18	NZ_CP018870.1	1698341-1698358	1	0.944
NZ_CP018870_3	3.4|1698998|33|NZ_CP018870|CRT	1698998-1699030	33	NZ_CP018870.1	1698413-1698445	1	0.97
NZ_CP018870_16	16.2|4630505|26|NZ_CP018870|CRISPRCasFinder	4630505-4630530	26	NZ_CP018870.1	4727758-4727783	1	0.962
NZ_CP018870_18	18.1|5662536|48|NZ_CP018870|CRISPRCasFinder	5662536-5662583	48	NZ_CP018870.1	6492299-6492346	1	0.979
NZ_CP018870_3	3.1|1698887|21|NZ_CP018870|CRT	1698887-1698907	21	NZ_CP018870.1	1698341-1698361	2	0.905
NZ_CP018870_3	3.1|1698887|21|NZ_CP018870|CRT	1698887-1698907	21	NZ_CP018870.1	1698560-1698580	2	0.905
NZ_CP018870_3	3.1|1698887|21|NZ_CP018870|CRT	1698887-1698907	21	NZ_CP018870.1	1698779-1698799	2	0.905
NZ_CP018870_3	3.4|1698998|33|NZ_CP018870|CRT	1698998-1699030	33	NZ_CP018870.1	1698143-1698175	2	0.939
NZ_CP018870_3	3.4|1698998|33|NZ_CP018870|CRT	1698998-1699030	33	NZ_CP018870.1	1698560-1698592	2	0.939
NZ_CP018870_3	3.4|1698998|33|NZ_CP018870|CRT	1698998-1699030	33	NZ_CP018870.1	1698779-1698811	2	0.939
NZ_CP018870_4	4.1|1835889|20|NZ_CP018870|CRISPRCasFinder	1835889-1835908	20	NZ_CP018870.1	5138478-5138497	2	0.9
NZ_CP018870_12	12.1|3238713|49|NZ_CP018870|CRISPRCasFinder	3238713-3238761	49	NZ_CP018870.1	3238804-3238852	2	0.959

1. spacer 3.1|1698887|21|NZ_CP018870|CRT matches to position: 1698668-1698688, mismatch: 0, identity: 1.0

gggtaggacgggcggtcgccg	CRISPR spacer
gggtaggacgggcggtcgccg	Protospacer
*********************

2. spacer 3.2|1698926|18|NZ_CP018870|CRT matches to position: 1698707-1698724, mismatch: 0, identity: 1.0

gggtaagagggacggtcg	CRISPR spacer
gggtaagagggacggtcg	Protospacer
******************

3. spacer 3.3|1698962|18|NZ_CP018870|CRT matches to position: 1698377-1698394, mismatch: 0, identity: 1.0

aaggagggacggtcgcca	CRISPR spacer
aaggagggacggtcgcca	Protospacer
******************

4. spacer 3.3|1698962|18|NZ_CP018870|CRT matches to position: 1698743-1698760, mismatch: 0, identity: 1.0

aaggagggacggtcgcca	CRISPR spacer
aaggagggacggtcgcca	Protospacer
******************

5. spacer 13.1|4195394|40|NZ_CP018870|CRISPRCasFinder matches to position: 4423581-4423620, mismatch: 0, identity: 1.0

gcctatgtccagccacaggggtccgctgacgccgtccttc	CRISPR spacer
gcctatgtccagccacaggggtccgctgacgccgtccttc	Protospacer
****************************************

6. spacer 22.1|7564175|40|NZ_CP018870|CRISPRCasFinder matches to position: 20821-20860, mismatch: 0, identity: 1.0

atccgggagaccgacttcgacggccgtgtgctcgactacg	CRISPR spacer
atccgggagaccgacttcgacggccgtgtgctcgactacg	Protospacer
****************************************

7. spacer 23.1|7564481|40|NZ_CP018870|CRISPRCasFinder matches to position: 20515-20554, mismatch: 0, identity: 1.0

accggccgaaccacccccacgggcgccgtcgccgcctggg	CRISPR spacer
accggccgaaccacccccacgggcgccgtcgccgcctggg	Protospacer
****************************************

8. spacer 23.2|7564544|37|NZ_CP018870|CRISPRCasFinder matches to position: 20455-20491, mismatch: 0, identity: 1.0

gacgccctgaccacgtccggccgccggatcggcttca	CRISPR spacer
gacgccctgaccacgtccggccgccggatcggcttca	Protospacer
*************************************

9. spacer 3.1|1698887|21|NZ_CP018870|CRT matches to position: 1698251-1698271, mismatch: 1, identity: 0.952

gggtaggacgggcggtcgccg	CRISPR spacer
gggtacgacgggcggtcgccg	Protospacer
***** ***************

10. spacer 3.2|1698926|18|NZ_CP018870|CRT matches to position: 1698341-1698358, mismatch: 1, identity: 0.944

gggtaagagggacggtcg	CRISPR spacer
gggtaggagggacggtcg	Protospacer
*****.************

11. spacer 3.4|1698998|33|NZ_CP018870|CRT matches to position: 1698413-1698445, mismatch: 1, identity: 0.97

gggtaggacggacggtcaccaccacggtcgtca	CRISPR spacer
gggtaggacggacggtcgccaccacggtcgtca	Protospacer
*****************.***************

12. spacer 16.2|4630505|26|NZ_CP018870|CRISPRCasFinder matches to position: 4727758-4727783, mismatch: 1, identity: 0.962

cgcctcgcagaagcgcgtagcgatcg	CRISPR spacer
cgactcgcagaagcgcgtagcgatcg	Protospacer
** ***********************

13. spacer 18.1|5662536|48|NZ_CP018870|CRISPRCasFinder matches to position: 6492299-6492346, mismatch: 1, identity: 0.979

caccggcccgggccgacgcccgaaccgctacccccgcgggagcggaag	CRISPR spacer
caccggcccgggccggcgcccgaaccgctacccccgcgggagcggaag	Protospacer
***************.********************************

14. spacer 3.1|1698887|21|NZ_CP018870|CRT matches to position: 1698341-1698361, mismatch: 2, identity: 0.905

gggtaggacgggcggtcgccg	CRISPR spacer
gggtaggagggacggtcgccg	Protospacer
******** **.*********

15. spacer 3.1|1698887|21|NZ_CP018870|CRT matches to position: 1698560-1698580, mismatch: 2, identity: 0.905

gggtaggacgggcggtcgccg	CRISPR spacer
gggtaggacggacggtcaccg	Protospacer
***********.*****.***

16. spacer 3.1|1698887|21|NZ_CP018870|CRT matches to position: 1698779-1698799, mismatch: 2, identity: 0.905

gggtaggacgggcggtcgccg	CRISPR spacer
gggtaggacggacggtcaccg	Protospacer
***********.*****.***

17. spacer 3.4|1698998|33|NZ_CP018870|CRT matches to position: 1698143-1698175, mismatch: 2, identity: 0.939

gggtaggacggacggtcaccaccacggtcgtca	CRISPR spacer
gggtaggacggacggtcgccaccgcggtcgtca	Protospacer
*****************.*****.*********

18. spacer 3.4|1698998|33|NZ_CP018870|CRT matches to position: 1698560-1698592, mismatch: 2, identity: 0.939

gggtaggacggacggtcaccaccacggtcgtca	CRISPR spacer
gggtaggacggacggtcaccgccgcggtcgtca	Protospacer
********************.**.*********

19. spacer 3.4|1698998|33|NZ_CP018870|CRT matches to position: 1698779-1698811, mismatch: 2, identity: 0.939

gggtaggacggacggtcaccaccacggtcgtca	CRISPR spacer
gggtaggacggacggtcaccgccgcggtcgtca	Protospacer
********************.**.*********

20. spacer 4.1|1835889|20|NZ_CP018870|CRISPRCasFinder matches to position: 5138478-5138497, mismatch: 2, identity: 0.9

gtcaccccgtccgcgccggt	CRISPR spacer
gtcaccccgtacgcgcaggt	Protospacer
********** ***** ***

21. spacer 12.1|3238713|49|NZ_CP018870|CRISPRCasFinder matches to position: 3238804-3238852, mismatch: 2, identity: 0.959

tttgaggcacgggccccgcggcggagccccggcacacacccgaccacca	CRISPR spacer
tttaaggcgcgggccccgcggcggagccccggcacacacccgaccacca	Protospacer
***.****.****************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP018870_3	3.1|1698887|21|NZ_CP018870|CRT	1698887-1698907	21	CP040467	Streptomyces albidoflavus strain UYFA156 plasmid unnamed, complete sequence	183627-183647	1	0.952
NZ_CP018870_20	20.4|7303677|24|NZ_CP018870|CRT	7303677-7303700	24	NZ_CP023152	Mycobacterium chimaera strain FLAC0070 plasmid pFLAC0070_1, complete sequence	243193-243216	3	0.875
NZ_CP018870_20	20.4|7303677|24|NZ_CP018870|CRT	7303677-7303700	24	MK967377	Gordonia phage MagicMan, complete genome	15304-15327	3	0.875
NZ_CP018870_20	20.4|7303677|24|NZ_CP018870|CRT	7303677-7303700	24	NC_031255	Gordonia phage Schwabeltier, complete genome	15305-15328	3	0.875
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_AP020327	Mycobacterium avium subsp. hominissuis strain JP-H-1 plasmid p1-JPH1	154637-154666	4	0.867
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	MK494105	Mycobacterium phage Pinnie, complete genome	23529-23558	4	0.867
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	508010-508039	4	0.867
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP045120	Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence	60079-60108	4	0.867
NZ_CP018870_16	16.2|4630505|26|NZ_CP018870|CRISPRCasFinder	4630505-4630530	26	NC_009621	Sinorhizobium medicae WSM419 plasmid pSMED02, complete sequence	682464-682489	4	0.846
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP029777	Deinococcus actinosclerus strain Deinococcus actinosclerus SJTR plasmid unnamed3, complete sequence	260508-260537	5	0.833
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_017966	Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence	366280-366309	5	0.833
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	971629-971658	5	0.833
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	918247-918276	5	0.833
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP053022	Sphingobium yanoikuyae strain YC-XJ2 plasmid p-A-Sy, complete sequence	351678-351707	5	0.833
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP054621	Azospirillum oryzae strain KACC 14407 plasmid unnamed6, complete sequence	784035-784064	5	0.833
NZ_CP018870_16	16.2|4630505|26|NZ_CP018870|CRISPRCasFinder	4630505-4630530	26	NC_010510	Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence	507330-507355	5	0.808
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	359846-359875	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	362215-362244	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP054615	Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence	125406-125435	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_028791	Mycobacterium phage MOOREtheMARYer, complete genome	38785-38814	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP016082	Streptomyces sp. SAT1 plasmid unnamed2, complete sequence	300979-301008	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP012185	Pseudonocardia sp. EC080619-01 plasmid pBCI1-2, complete sequence	467258-467287	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP013110	Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence	1333143-1333172	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	205884-205913	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_015169	Deinococcus proteolyticus MRP plasmid pDEIPR01, complete sequence	233427-233456	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	1607235-1607264	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_013859	Azospirillum sp. B510 plasmid pAB510e, complete sequence	277428-277457	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP015881	Ensifer adhaerens strain Casida A plasmid pCasidaAA, complete sequence	694465-694494	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP030263	Ensifer adhaerens strain Corn53 plasmid AA, complete sequence	1522594-1522623	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP013054	Sinorhizobium americanum CCGM7 plasmid C, complete sequence	1078243-1078272	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_014309	Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome	440180-440209	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP029362	Streptomyces globisporus strain TFH56 plasmid pTFSG1, complete sequence	63813-63842	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_010847	Paracoccus aminophilus strain JCM 7686 plasmid pAMI2, complete sequence	428-457	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP040820	Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence	191729-191758	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	MG962374	Mycobacterium phage Paola, complete genome	33389-33418	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	KX585251	Mycobacterium phage Waterfoul, complete genome	33630-33659	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	MH051255	Mycobacterium phage Leston, complete genome	33519-33548	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	KX636165	Mycobacterium phage Gengar, complete genome	33418-33447	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	MF185720	Mycobacterium phage Guillsminger, complete genome	33389-33418	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_024366	Mycobacterium phage OkiRoe, complete genome	33391-33420	6	0.8
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	MH576966	Mycobacterium phage Thyatira, complete genome	35736-35765	6	0.8
NZ_CP018870_7	7.1|2056232|32|NZ_CP018870|CRISPRCasFinder	2056232-2056263	32	NZ_CP035515	Haematobacter massiliensis strain OT1 plasmid pOT1-5, complete sequence	46635-46666	6	0.812
NZ_CP018870_7	7.1|2056232|32|NZ_CP018870|CRISPRCasFinder	2056232-2056263	32	NZ_AP022340	Mameliella alba strain KU6B plasmid pKUB77, complete sequence	6417-6448	6	0.812
NZ_CP018870_15	15.1|4540368|27|NZ_CP018870|CRISPRCasFinder	4540368-4540394	27	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	504809-504835	6	0.778
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	255824-255853	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_017966	Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence	342713-342742	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	AB452989	Serratia phage KSP20 orf7 to orf11 genes for scaffolding protein, major capsid protein, terminase, head completion protein, hypothetical protein, complete and partial cds	1651-1680	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_015724	Cupriavidus necator N-1 plasmid pBB2, complete sequence	109460-109489	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	1741652-1741681	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_023285	Streptomyces sp. F8 plasmid pFRL5, complete sequence	88971-89000	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	1099754-1099783	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	1121946-1121975	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP029358	Azospirillum sp. CFH 70021 plasmid unnamed3	4244-4273	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_017957	Tistrella mobilis KA081020-065 plasmid pTM1, complete sequence	640426-640455	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_012811	Methylorubrum extorquens AM1 megaplasmid, complete sequence	63592-63621	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP032325	Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence	616849-616878	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP022366	Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence	443065-443094	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP007796	Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence	29978-30007	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP029834	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed4, complete sequence	417017-417046	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	313125-313154	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP026653	Streptomyces dengpaensis strain XZHG99 plasmid unnamed1, complete sequence	8999-9028	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_023714	Mycobacterium phage LinStu, complete genome	80691-80720	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	GQ303262	Mycobacterium phage LRRHood, complete genome	80082-80111	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	MT889395	Mycobacterium phage Shifa, complete genome	79056-79085	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	MH910040	Mycobacterium phage Sauce, complete genome	79780-79809	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	MN062707	Mycobacterium phage Grungle, complete genome	77112-77141	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	KX831080	Mycobacterium phage Lukilu, complete genome	81092-81121	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_028869	Mycobacterium phage HyRo, complete genome	79790-79819	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	MF919513	Mycobacterium phage Koguma, complete genome	78274-78303	7	0.767
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	JN204348	Mycobacterium phage Sebata, complete genome	81249-81278	7	0.767
NZ_CP018870_7	7.1|2056232|32|NZ_CP018870|CRISPRCasFinder	2056232-2056263	32	NZ_CP010698	Phaeobacter inhibens strain P24 plasmid pP24_b, complete sequence	102579-102610	7	0.781
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	MN234206	Arthrobacter phage Racecar, complete genome	71068-71097	7	0.767
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	MN234211	Arthrobacter phage Mimi, complete genome	69746-69775	7	0.767
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	NZ_CP032349	Azospirillum brasilense strain MTCC4039 plasmid p3, complete sequence	549598-549627	7	0.767
NZ_CP018870_20	20.3|7303629|30|NZ_CP018870|CRT	7303629-7303658	30	NZ_CP021653	Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence	40458-40487	7	0.767
NZ_CP018870_20	20.3|7303629|30|NZ_CP018870|CRT	7303629-7303658	30	NC_012520	Rhodococcus opacus B4 plasmid pROB01, complete sequence	536746-536775	7	0.767
NZ_CP018870_20	20.3|7303629|30|NZ_CP018870|CRT	7303629-7303658	30	NC_023285	Streptomyces sp. F8 plasmid pFRL5, complete sequence	398512-398541	7	0.767
NZ_CP018870_20	20.3|7303629|30|NZ_CP018870|CRT	7303629-7303658	30	NZ_CP012688	Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence	40458-40487	7	0.767
NZ_CP018870_20	20.3|7303629|30|NZ_CP018870|CRT	7303629-7303658	30	CP047139	Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence	112567-112596	7	0.767
NZ_CP018870_20	20.3|7303629|30|NZ_CP018870|CRT	7303629-7303658	30	CP047137	Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence	101653-101682	7	0.767
NZ_CP018870_3	3.5|1699049|42|NZ_CP018870|CRT	1699049-1699090	42	NZ_CP045191	Escherichia coli strain NT1F31 plasmid pNT1F31-113kb, complete sequence	42873-42914	8	0.81
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	353181-353210	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP054615	Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence	72996-73025	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_016588	Azospirillum lipoferum 4B plasmid AZO_p6, complete sequence	187086-187115	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_016588	Azospirillum lipoferum 4B plasmid AZO_p6, complete sequence	263945-263974	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_LR134461	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 19, complete sequence	93470-93499	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_HG938356	Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence	532686-532715	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP029830	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed1, complete sequence	839821-839850	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	1535248-1535277	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP021119	Streptomyces sp. CLI2509 strain CLI2905 plasmid unnamed1, complete sequence	19002-19031	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP054618	Azospirillum oryzae strain KACC 14407 plasmid unnamed4, complete sequence	394759-394788	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP039640	Azospirillum sp. TSH100 plasmid p1, complete sequence	250018-250047	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_016585	Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence	371543-371572	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_016585	Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence	40989-41018	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP018096	Chelatococcus daeguensis strain TAD1 plasmid pTAD1, complete sequence	195997-196026	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP007214	Burkholderia plantarii strain ATCC 43733 plasmid bpln_1p, complete sequence	4592-4621	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP054841	Acidovorax sp. 16-35-5 plasmid unnamed1, complete sequence	546373-546402	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP039425	Citricoccus sp. SGAir0253 plasmid unnamed1, complete sequence	71178-71207	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_AP022607	Mycobacterium branderi strain JCM 12687 plasmid pJCM12687	755079-755108	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP012399	Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence	222150-222179	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	69577-69606	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_020548	Azoarcus sp. KH32C plasmid pAZKH, complete sequence	282840-282869	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP039430	Citricoccus sp. SGAir0453 plasmid unnamed1, complete sequence	71176-71205	8	0.733
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	KR080197	Mycobacterium phage FlagStaff, complete genome	24277-24306	8	0.733
NZ_CP018870_7	7.1|2056232|32|NZ_CP018870|CRISPRCasFinder	2056232-2056263	32	NZ_CP015007	Aminobacter aminovorans strain KCTC 2477 plasmid pAA02, complete sequence	139366-139397	8	0.75
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	MN693056	Marine virus AFVG_25M10, complete genome	298-327	8	0.733
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	MN693056	Marine virus AFVG_25M10, complete genome	57733-57762	8	0.733
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	MN693342	Marine virus AFVG_25M9, complete genome	298-327	8	0.733
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	MN693342	Marine virus AFVG_25M9, complete genome	57454-57483	8	0.733
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	NZ_KY349138	Mycolicibacterium sp. CBMA 213 plasmid pCBMA213_2, complete sequence	11483-11512	8	0.733
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	MN693020	Marine virus AFVG_117M64, complete genome	2034-2063	8	0.733
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	MN693020	Marine virus AFVG_117M64, complete genome	59384-59413	8	0.733
NZ_CP018870_3	3.5|1699049|42|NZ_CP018870|CRT	1699049-1699090	42	NZ_AP014579	Burkholderia sp. RPE67 plasmid p1, complete sequence	390702-390743	9	0.786
NZ_CP018870_3	3.5|1699049|42|NZ_CP018870|CRT	1699049-1699090	42	NZ_CP021767	Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence	1494324-1494365	9	0.786
NZ_CP018870_3	3.5|1699049|42|NZ_CP018870|CRT	1699049-1699090	42	NZ_CP045327	Mycobacterium sp. THAF192 plasmid pTHAF192_b, complete sequence	11557-11598	9	0.786
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_017966	Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence	522362-522391	9	0.7
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	781035-781064	9	0.7
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_024970	Streptomyces aureofaciens strain CCM3239 plasmid pSA3239, complete sequence	202341-202370	9	0.7
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_KJ396772	Streptomyces lavendulae subsp. lavendulae strain CCM3239 plasmid pSA3239, complete sequence	202341-202370	9	0.7
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_016624	Azospirillum lipoferum 4B plasmid AZO_p5, complete sequence	47960-47989	9	0.7
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP024986	Streptomyces lavendulae subsp. lavendulae strain CCM 3239 plasmid pSA3239, complete sequence	38707-38736	9	0.7
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	KT309034	Mycobacterium phage Dante, complete genome	24935-24964	9	0.7
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_048850	Mycobacterium phage Cornie, complete genome	23377-23406	9	0.7
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_021538	Mycobacterium phage Job42, complete genome	26603-26632	9	0.7
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_026584	Mycobacterium phage Minerva, complete genome	38814-38843	9	0.7
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	KJ409696	Mycobacterium phage Lamina13, complete genome	28276-28305	9	0.7
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NC_028784	Mycobacterium phage Tasp14, complete genome	28900-28929	9	0.7
NZ_CP018870_7	7.1|2056232|32|NZ_CP018870|CRISPRCasFinder	2056232-2056263	32	NZ_CP030129	Indioceanicola profundi strain SCSIO 08040 plasmid unnamed3, complete sequence	131476-131507	9	0.719
NZ_CP018870_7	7.1|2056232|32|NZ_CP018870|CRISPRCasFinder	2056232-2056263	32	NZ_CP022305	Thalassococcus sp. S3 plasmid pS3B, complete sequence	48713-48744	9	0.719
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	MN693542	Marine virus AFVG_25M165, complete genome	294-323	9	0.7
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	MN693542	Marine virus AFVG_25M165, complete genome	57019-57048	9	0.7
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	MN694128	Marine virus AFVG_250M1142, complete genome	35594-35623	9	0.7
NZ_CP018870_20	20.1|7303545|30|NZ_CP018870|CRT	7303545-7303574	30	NZ_CP049029	Fluviibacterium aquatile strain SC52 plasmid pSC52_1, complete sequence	266620-266649	9	0.7
NZ_CP018870_3	3.4|1698998|33|NZ_CP018870|CRT	1698998-1699030	33	NZ_CP029776	Deinococcus actinosclerus strain Deinococcus actinosclerus SJTR plasmid unnamed2, complete sequence	44618-44650	10	0.697
NZ_CP018870_3	3.5|1699049|42|NZ_CP018870|CRT	1699049-1699090	42	MK977696	Gordonia phage SCentae, complete genome	119741-119782	10	0.762
NZ_CP018870_3	3.5|1699049|42|NZ_CP018870|CRT	1699049-1699090	42	MK977695	Gordonia phage Pupper, complete genome	119587-119628	10	0.762
NZ_CP018870_3	3.5|1699049|42|NZ_CP018870|CRT	1699049-1699090	42	MK524490	Mycobacterium phage Donny, complete genome	31913-31954	10	0.762
NZ_CP018870_3	3.5|1699049|42|NZ_CP018870|CRT	1699049-1699090	42	JN699007	Mycobacterium phage Acadian, complete genome	31908-31949	10	0.762
NZ_CP018870_3	3.5|1699049|42|NZ_CP018870|CRT	1699049-1699090	42	MT889381	Mycobacterium phage Suigeneris, complete genome	31913-31954	10	0.762
NZ_CP018870_7	7.1|2056232|32|NZ_CP018870|CRISPRCasFinder	2056232-2056263	32	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	994570-994601	10	0.688
NZ_CP018870_3	3.5|1699049|42|NZ_CP018870|CRT	1699049-1699090	42	AP013441	Uncultured Mediterranean phage uvMED DNA, complete genome, group G17, isolate: uvMED-CGR-C22-MedDCM-OCT-S33-C34	21800-21841	11	0.738
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP054615	Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence	296202-296231	15	0.5
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP045310	Micromonospora terminaliae strain DSM 101760 plasmid pLB1, complete sequence	16487-16516	17	0.433
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP045310	Micromonospora terminaliae strain DSM 101760 plasmid pLB1, complete sequence	18992-19021	17	0.433
NZ_CP018870_3	3.6|1699109|30|NZ_CP018870|CRT	1699109-1699138	30	NZ_CP013739	Streptomyces globisporus C-1027 plasmid SGLP1, complete sequence	57264-57293	19	0.367

1. spacer 3.1|1698887|21|NZ_CP018870|CRT matches to CP040467 (Streptomyces albidoflavus strain UYFA156 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.952

gggtaggacgggcggtcgccg	CRISPR spacer
gggtaggacgggccgtcgccg	Protospacer
************* *******

2. spacer 20.4|7303677|24|NZ_CP018870|CRT matches to NZ_CP023152 (Mycobacterium chimaera strain FLAC0070 plasmid pFLAC0070_1, complete sequence) position: , mismatch: 3, identity: 0.875

aggccccgcaggaggctccggcga	CRISPR spacer
aggcccagcaggaggctgcggcgg	Protospacer
****** ********** *****.

3. spacer 20.4|7303677|24|NZ_CP018870|CRT matches to MK967377 (Gordonia phage MagicMan, complete genome) position: , mismatch: 3, identity: 0.875

aggccccgcaggaggctccggcga	CRISPR spacer
cggccccgcaggcggcgccggcga	Protospacer
 *********** *** *******

4. spacer 20.4|7303677|24|NZ_CP018870|CRT matches to NC_031255 (Gordonia phage Schwabeltier, complete genome) position: , mismatch: 3, identity: 0.875

aggccccgcaggaggctccggcga	CRISPR spacer
cggccccgcaggcggcgccggcga	Protospacer
 *********** *** *******

5. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_AP020327 (Mycobacterium avium subsp. hominissuis strain JP-H-1 plasmid p1-JPH1) position: , mismatch: 4, identity: 0.867

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gcgccgccaccaccaccggccggccagccg	Protospacer
  ************.**********.****

6. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to MK494105 (Mycobacterium phage Pinnie, complete genome) position: , mismatch: 4, identity: 0.867

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccgccgccggccggctggccg	Protospacer
. *********.************.*****

7. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 4, identity: 0.867

tagccg-ccaccaccgccggccggccggccg	CRISPR spacer
-agctgtcctccaccgccggcctgccggccg	Protospacer
 ***.* ** ************ ********

8. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP045120 (Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.867

tagccgccaccaccgccggccggccggccg-	CRISPR spacer
tccccgccacctccgccggccgg-cggccgc	Protospacer
*  ******** *********** ****** 

9. spacer 16.2|4630505|26|NZ_CP018870|CRISPRCasFinder matches to NC_009621 (Sinorhizobium medicae WSM419 plasmid pSMED02, complete sequence) position: , mismatch: 4, identity: 0.846

cgcctcgcagaagcgcgtagcgatcg	CRISPR spacer
cgcctcgtagaagcgcgttgcgactg	Protospacer
*******.********** ****..*

10. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP029777 (Deinococcus actinosclerus strain Deinococcus actinosclerus SJTR plasmid unnamed3, complete sequence) position: , mismatch: 5, identity: 0.833

-tagccgccaccaccgccggccggccggccg	CRISPR spacer
gcagct-ccaccacggccggccggccggcct	Protospacer
 .***. ******* *************** 

11. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_017966 (Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence) position: , mismatch: 5, identity: 0.833

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tcggcatcaccaccgccggccggccgcccg	Protospacer
* * *..******************* ***

12. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 5, identity: 0.833

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tcgccaccaccaccggcggccggccgggca	Protospacer
* ***.********* *********** *.

13. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 5, identity: 0.833

-tagccgccaccaccgccggccggccggccg	CRISPR spacer
gcaggcg-catcgccgccggccggccggccg	Protospacer
 .** ** **.*.******************

14. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP053022 (Sphingobium yanoikuyae strain YC-XJ2 plasmid p-A-Sy, complete sequence) position: , mismatch: 5, identity: 0.833

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tagccgccagcaccgccggcctgcagcctg	Protospacer
********* *********** ** * *.*

15. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP054621 (Azospirillum oryzae strain KACC 14407 plasmid unnamed6, complete sequence) position: , mismatch: 5, identity: 0.833

tagc-cgccaccaccgccggccggccggccg	CRISPR spacer
-agcgcgccaccacctgcggccggccggcgt	Protospacer
 *** **********  ************  

16. spacer 16.2|4630505|26|NZ_CP018870|CRISPRCasFinder matches to NC_010510 (Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence) position: , mismatch: 5, identity: 0.808

cgcctcgcagaagcgcgtagcgatcg	CRISPR spacer
cgcctcgcagaagcgcgtcccgacac	Protospacer
******************  ***.  

17. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tcaccgccacggccgccggccggccggcga	Protospacer
* .******* .**************** .

18. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tgacgccgaccaccgccggccggccggcca	Protospacer
*..*  * *********************.

19. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP054615 (Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tgatcgccaccaccgccggccggctgtcct	Protospacer
*...********************.* ** 

20. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_028791 (Mycobacterium phage MOOREtheMARYer, complete genome) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
aggccgcgacgaccgccggccggccggact	Protospacer
 .***** ** **************** * 

21. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP016082 (Streptomyces sp. SAT1 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
cggccggccccaccgccggccggccgcacg	Protospacer
..**** * *****************  **

22. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP012185 (Pseudonocardia sp. EC080619-01 plasmid pBCI1-2, complete sequence) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gcgacaccaccaccgccggccgctcggccg	Protospacer
  * *.**************** .******

23. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP013110 (Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gcgccgccccctccgccggccggccgccgg	Protospacer
  ****** ** ************** * *

24. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 6, identity: 0.8

-tagccgccaccaccgccggccggccggccg	CRISPR spacer
cgaatcgct-ccacccccggccggccggccg	Protospacer
  *..***. ***** ***************

25. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_015169 (Deinococcus proteolyticus MRP plasmid pDEIPR01, complete sequence) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggc-cggccggccg	CRISPR spacer
cggccgccaccaccgccggcacgcccaggc-	Protospacer
..****************** ** **.* * 

26. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 6, identity: 0.8

-tagccgccaccaccgccggccggccggccg	CRISPR spacer
cgaatcgct-ccacccccggccggccggccg	Protospacer
  *..***. ***** ***************

27. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_013859 (Azospirillum sp. B510 plasmid pAB510e, complete sequence) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tcgccgccgccaccgccggccagcccgacc	Protospacer
* ******.************.*** * * 

28. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP015881 (Ensifer adhaerens strain Casida A plasmid pCasidaAA, complete sequence) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tgacctgcacctccgccggccggccggcct	Protospacer
*..**  **** ***************** 

29. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP030263 (Ensifer adhaerens strain Corn53 plasmid AA, complete sequence) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tgacctgcacctccgccggccggccggcct	Protospacer
*..**  **** ***************** 

30. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP013054 (Sinorhizobium americanum CCGM7 plasmid C, complete sequence) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gcgccgccccctccgccggccggccgccgg	Protospacer
  ****** ** ************** * *

31. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_014309 (Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tggccaccaccacggccggccggcccgacc	Protospacer
*.***.******* *********** * * 

32. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP029362 (Streptomyces globisporus strain TFH56 plasmid pTFSG1, complete sequence) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tcgccgtcaccaccggcggccggcctccca	Protospacer
* ****.******** *********  **.

33. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_010847 (Paracoccus aminophilus strain JCM 7686 plasmid pAMI2, complete sequence) position: , mismatch: 6, identity: 0.8

-tagccgccaccaccgccggccggccggccg	CRISPR spacer
atgagcg-caccagcgccggccgggcggccg	Protospacer
 *.. ** ***** ********** ******

34. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP040820 (Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence) position: , mismatch: 6, identity: 0.8

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gagagggcaccaccgccggccggcgggcag	Protospacer
 **  * ***************** *** *

35. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to MG962374 (Mycobacterium phage Paola, complete genome) position: , mismatch: 6, identity: 0.8

-tagccgccaccaccgccggccggccggccg	CRISPR spacer
gtgagcg-caccatcaccggccggccggccg	Protospacer
 *.. ** *****.*.***************

36. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to KX585251 (Mycobacterium phage Waterfoul, complete genome) position: , mismatch: 6, identity: 0.8

-tagccgccaccaccgccggccggccggccg	CRISPR spacer
gtgagcg-caccatcaccggccggccggccg	Protospacer
 *.. ** *****.*.***************

37. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to MH051255 (Mycobacterium phage Leston, complete genome) position: , mismatch: 6, identity: 0.8

-tagccgccaccaccgccggccggccggccg	CRISPR spacer
gtgagcg-caccatcaccggccggccggccg	Protospacer
 *.. ** *****.*.***************

38. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to KX636165 (Mycobacterium phage Gengar, complete genome) position: , mismatch: 6, identity: 0.8

-tagccgccaccaccgccggccggccggccg	CRISPR spacer
gtgagcg-caccatcaccggccggccggccg	Protospacer
 *.. ** *****.*.***************

39. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to MF185720 (Mycobacterium phage Guillsminger, complete genome) position: , mismatch: 6, identity: 0.8

-tagccgccaccaccgccggccggccggccg	CRISPR spacer
gtgagcg-caccatcaccggccggccggccg	Protospacer
 *.. ** *****.*.***************

40. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_024366 (Mycobacterium phage OkiRoe, complete genome) position: , mismatch: 6, identity: 0.8

--tagccgccaccaccgccggccggccggccg	CRISPR spacer
gtcagc--gcaccatcaccggccggccggccg	Protospacer
  .***   *****.*.***************

41. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to MH576966 (Mycobacterium phage Thyatira, complete genome) position: , mismatch: 6, identity: 0.8

-tagccgccaccaccgccggccggccggccg	CRISPR spacer
gtgagcg-caccatcaccggccggccggccg	Protospacer
 *.. ** *****.*.***************

42. spacer 7.1|2056232|32|NZ_CP018870|CRISPRCasFinder matches to NZ_CP035515 (Haematobacter massiliensis strain OT1 plasmid pOT1-5, complete sequence) position: , mismatch: 6, identity: 0.812

cctgaggcggagcccccgctcttccgccccgc	CRISPR spacer
aatcaggcgcagccgccgctcttccgccccgt	Protospacer
  * ***** **** ****************.

43. spacer 7.1|2056232|32|NZ_CP018870|CRISPRCasFinder matches to NZ_AP022340 (Mameliella alba strain KU6B plasmid pKUB77, complete sequence) position: , mismatch: 6, identity: 0.812

cctgaggcggagcccccgctcttccgccccgc	CRISPR spacer
aatcaggcgcagccgccgctcttccgccccgt	Protospacer
  * ***** **** ****************.

44. spacer 15.1|4540368|27|NZ_CP018870|CRISPRCasFinder matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 6, identity: 0.778

acgccgaaaactagtggccggccaggc	CRISPR spacer
cgatcgagaagtagtggccggccaggc	Protospacer
  ..***.** ****************

45. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
cgaccggctccaccgccggccggccggcga	Protospacer
...*** * ******************* .

46. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_017966 (Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ggaacgcctccaccgccggctggccggcct	Protospacer
 .. **** ***********.******** 

47. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to AB452989 (Serratia phage KSP20 orf7 to orf11 genes for scaffolding protein, major capsid protein, terminase, head completion protein, hypothetical protein, complete and partial cds) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gcgttgccaccaccgccggccggcgggcga	Protospacer
  *..******************* *** .

48. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_015724 (Cupriavidus necator N-1 plasmid pBB2, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
atgccgccaccgccgccggccggcttgacc	Protospacer
  *********.************. * * 

49. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccacccccgccggccggctgacgt	Protospacer
. ********* ************.*.*  

50. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_023285 (Streptomyces sp. F8 plasmid pFRL5, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg--	CRISPR spacer
ctaccgccaccaccgctggccggcc--tcgac	Protospacer
. .*************.********  .**  

51. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gcacggccaccacccgcggccggccggctg	Protospacer
  .* *********  ************.*

52. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gcacggccaccacccgcggccggccggctg	Protospacer
  .* *********  ************.*

53. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP029358 (Azospirillum sp. CFH 70021 plasmid unnamed3) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tctcggccaccgccgccggccggccggaat	Protospacer
*  * ******.***************   

54. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_017957 (Tistrella mobilis KA081020-065 plasmid pTM1, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgtcgccaccgccgccggcaggccggtca	Protospacer
. *.*******.******** ******.*.

55. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_012811 (Methylorubrum extorquens AM1 megaplasmid, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
aggccgccaccacggccggccggaccgtct	Protospacer
 .*********** ********* * *.* 

56. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP032325 (Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
cggcatgcaacaccgccggccggcccgccg	Protospacer
..**   ** *************** ****

57. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP022366 (Azospirillum sp. TSH58 plasmid TSH58_p04, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ttcccgtcaccaccgccggcccgccgactc	Protospacer
*  ***.************** ****.*. 

58. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP007796 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
cggcatgcagcaccgccggccggcccgccg	Protospacer
..**   ** *************** ****

59. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP029834 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed4, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg--	CRISPR spacer
acgccgccagcaccgccggcaggcc--ccagc	Protospacer
  ******* ********** ****  **.  

60. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
cacgcgggtcccccgccggccggccggccg	Protospacer
.*  **   ** ******************

61. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP026653 (Streptomyces dengpaensis strain XZHG99 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gagccgcccccaccgccggccgccacatcg	Protospacer
 ******* ************* *  ..**

62. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_023714 (Mycobacterium phage LinStu, complete genome) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccgccgccgcccggcccggcc	Protospacer
. *********.****** ****** * * 

63. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to GQ303262 (Mycobacterium phage LRRHood, complete genome) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccgccgccgcccggcccggcc	Protospacer
. *********.****** ****** * * 

64. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to MT889395 (Mycobacterium phage Shifa, complete genome) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccgccgccgcccggcccggcc	Protospacer
. *********.****** ****** * * 

65. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to MH910040 (Mycobacterium phage Sauce, complete genome) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccgccgccgcccggcccggcc	Protospacer
. *********.****** ****** * * 

66. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to MN062707 (Mycobacterium phage Grungle, complete genome) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccgccgccgcccggcccggcc	Protospacer
. *********.****** ****** * * 

67. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to KX831080 (Mycobacterium phage Lukilu, complete genome) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccgccgccgcccggcccggcc	Protospacer
. *********.****** ****** * * 

68. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_028869 (Mycobacterium phage HyRo, complete genome) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccgccgccgcccggcccggcc	Protospacer
. *********.****** ****** * * 

69. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to MF919513 (Mycobacterium phage Koguma, complete genome) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccgccgccgcccggcccggcc	Protospacer
. *********.****** ****** * * 

70. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to JN204348 (Mycobacterium phage Sebata, complete genome) position: , mismatch: 7, identity: 0.767

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccgccgccgcccggcccggcc	Protospacer
. *********.****** ****** * * 

71. spacer 7.1|2056232|32|NZ_CP018870|CRISPRCasFinder matches to NZ_CP010698 (Phaeobacter inhibens strain P24 plasmid pP24_b, complete sequence) position: , mismatch: 7, identity: 0.781

cctgaggcggagcccccgctcttccgccccgc	CRISPR spacer
aaccaggcgcagccgccgctcttccgccccgt	Protospacer
  . ***** **** ****************.

72. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to MN234206 (Arthrobacter phage Racecar, complete genome) position: , mismatch: 7, identity: 0.767

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
aagcccctgagaaggccccagccaaggaag	Protospacer
*.*****************.* ***.*   

73. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to MN234211 (Arthrobacter phage Mimi, complete genome) position: , mismatch: 7, identity: 0.767

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
aagcccctgagaaggccccagccaaggaag	Protospacer
*.*****************.* ***.*   

74. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to NZ_CP032349 (Azospirillum brasilense strain MTCC4039 plasmid p3, complete sequence) position: , mismatch: 7, identity: 0.767

aggcccctgagaaggccccggacaaagctc----	CRISPR spacer
aggcccatgagatggccccggac----ccccgtg	Protospacer
****** ***** **********    *.*    

75. spacer 20.3|7303629|30|NZ_CP018870|CRT matches to NZ_CP021653 (Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

cggctccggagaaggccccggacacaactc---	CRISPR spacer
cggctccggcgaaggccccgg---tgcctcgat	Protospacer
********* ***********   .. ***   

76. spacer 20.3|7303629|30|NZ_CP018870|CRT matches to NC_012520 (Rhodococcus opacus B4 plasmid pROB01, complete sequence) position: , mismatch: 7, identity: 0.767

cggctccggagaaggccccggacacaactc	CRISPR spacer
ccgctccggagaaggcctcggaccgcacgg	Protospacer
* ***************.*****   **  

77. spacer 20.3|7303629|30|NZ_CP018870|CRT matches to NC_023285 (Streptomyces sp. F8 plasmid pFRL5, complete sequence) position: , mismatch: 7, identity: 0.767

cggctccggagaaggccccggacacaactc	CRISPR spacer
cggcaacggagaaggccccggacctcggtc	Protospacer
****  ***************** . . **

78. spacer 20.3|7303629|30|NZ_CP018870|CRT matches to NZ_CP012688 (Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

cggctccggagaaggccccggacacaactc---	CRISPR spacer
cggctccggcgaaggccccgg---tgcctcgat	Protospacer
********* ***********   .. ***   

79. spacer 20.3|7303629|30|NZ_CP018870|CRT matches to CP047139 (Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

cggctccggagaaggccccggacacaactc---	CRISPR spacer
cggctccggcgaaggccccgg---tgcctcgat	Protospacer
********* ***********   .. ***   

80. spacer 20.3|7303629|30|NZ_CP018870|CRT matches to CP047137 (Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

cggctccggagaaggccccggacacaactc---	CRISPR spacer
cggctccggcgaaggccccgg---tgcctcgat	Protospacer
********* ***********   .. ***   

81. spacer 3.5|1699049|42|NZ_CP018870|CRT matches to NZ_CP045191 (Escherichia coli strain NT1F31 plasmid pNT1F31-113kb, complete sequence) position: , mismatch: 8, identity: 0.81

aagccgccgccaccgccaccgccaccgccgg-aggggcgcccg	CRISPR spacer
gagctaccgccaccgccaccgccaccgccggcaatagcgcca-	Protospacer
.***..************************* *. .*****  

82. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
agaaggcgaccaccgccggccggccggtgg	Protospacer
 ..  ** *******************. *

83. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP054615 (Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccttcgccaccgccgccggcctgccggtgg	Protospacer
.  .*******.********* *****. *

84. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_016588 (Azospirillum lipoferum 4B plasmid AZO_p6, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
atccggcctccacctccggccggccggcgc	Protospacer
   * *** ***** *************  

85. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_016588 (Azospirillum lipoferum 4B plasmid AZO_p6, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccttcgccaccgccgccggcctgccggtgg	Protospacer
.  .*******.********* *****. *

86. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_LR134461 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 19, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
actccgccaccgccgccggccggcctccac	Protospacer
   ********.*************  *  

87. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_HG938356 (Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tccgcgccacgaccgccggccggccgcagc	Protospacer
*   ****** ***************    

88. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP029830 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gccgcgccaccacctgcggccggccggcgt	Protospacer
    **********  ************  

89. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccagcacctccggccggccgatgc	Protospacer
. ******* **** ***********..  

90. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP021119 (Streptomyces sp. CLI2509 strain CLI2905 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
cggccgccaccaccgtcgcccggccgcgac	Protospacer
..*************.** *******    

91. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP054618 (Azospirillum oryzae strain KACC 14407 plasmid unnamed4, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ctacaccgaccgccgccggccggccggcca	Protospacer
. .*  * ***.*****************.

92. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP039640 (Azospirillum sp. TSH100 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccttcgccaccgccgccggcctgccggtgg	Protospacer
.  .*******.********* *****. *

93. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_016585 (Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gccgcgccaccacctgcggccggccggcgt	Protospacer
    **********  ************  

94. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_016585 (Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccttctccgccaccgccggcaggccggcca	Protospacer
.  .* **.*********** ********.

95. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP018096 (Chelatococcus daeguensis strain TAD1 plasmid pTAD1, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
cgccgctcaccacggccgaccggccggccg	Protospacer
.. *  .****** ****.***********

96. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP007214 (Burkholderia plantarii strain ATCC 43733 plasmid bpln_1p, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
cttatgccaccgccgccggccggccgctcg	Protospacer
.   .******.************** .**

97. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP054841 (Acidovorax sp. 16-35-5 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
tggccgccacccccgcccgccggcctttgc	Protospacer
*.********* ***** *******  .  

98. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP039425 (Citricoccus sp. SGAir0253 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
acgccgccgccatcgccggccggcccatca	Protospacer
  ******.***.************ ..*.

99. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_AP022607 (Mycobacterium branderi strain JCM 12687 plasmid pJCM12687) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
cgccggacaccaccgccgggcggccggcat	Protospacer
.. * * ************ ********  

100. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP012399 (Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
cgccgctcaccacggccgaccggccggccg	Protospacer
.. *  .****** ****.***********

101. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gggacgccaccgccgcgggccggccggtga	Protospacer
 .* *******.**** **********. .

102. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_020548 (Azoarcus sp. KH32C plasmid pAZKH, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
acttcgccaccacctccggacggccggtct	Protospacer
   .********** **** *******.* 

103. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP039430 (Citricoccus sp. SGAir0453 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
acgccgccgccatcgccggccggcccatca	Protospacer
  ******.***.************ ..*.

104. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to KR080197 (Mycobacterium phage FlagStaff, complete genome) position: , mismatch: 8, identity: 0.733

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccgccgccggcctgcccagcc	Protospacer
. *********.********* *** . * 

105. spacer 7.1|2056232|32|NZ_CP018870|CRISPRCasFinder matches to NZ_CP015007 (Aminobacter aminovorans strain KCTC 2477 plasmid pAA02, complete sequence) position: , mismatch: 8, identity: 0.75

cctgaggcggagcccccgctcttccgccccgc	CRISPR spacer
aatcaggcgcagccgccgctcttccgcccgat	Protospacer
  * ***** **** ************** ..

106. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to MN693056 (Marine virus AFVG_25M10, complete genome) position: , mismatch: 8, identity: 0.733

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
accaccctgagaaggcgccggacaattggc	Protospacer
*   ************ ********    *

107. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to MN693056 (Marine virus AFVG_25M10, complete genome) position: , mismatch: 8, identity: 0.733

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
accaccctgagaaggcgccggacaattggc	Protospacer
*   ************ ********    *

108. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to MN693342 (Marine virus AFVG_25M9, complete genome) position: , mismatch: 8, identity: 0.733

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
accaccctgagaaggcgccggacaattggc	Protospacer
*   ************ ********    *

109. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to MN693342 (Marine virus AFVG_25M9, complete genome) position: , mismatch: 8, identity: 0.733

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
accaccctgagaaggcgccggacaattggc	Protospacer
*   ************ ********    *

110. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to NZ_KY349138 (Mycolicibacterium sp. CBMA 213 plasmid pCBMA213_2, complete sequence) position: , mismatch: 8, identity: 0.733

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
aggcccccgagaaggcccaggacgtgccga	Protospacer
*******.********** ****. . *  

111. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to MN693020 (Marine virus AFVG_117M64, complete genome) position: , mismatch: 8, identity: 0.733

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
accaccctgagaaggcgccggacaattggc	Protospacer
*   ************ ********    *

112. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to MN693020 (Marine virus AFVG_117M64, complete genome) position: , mismatch: 8, identity: 0.733

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
accaccctgagaaggcgccggacaattggc	Protospacer
*   ************ ********    *

113. spacer 3.5|1699049|42|NZ_CP018870|CRT matches to NZ_AP014579 (Burkholderia sp. RPE67 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.786

aagccgccgccaccgccaccgccaccgccggaggggcgcccg	CRISPR spacer
cggccgccgccaccgccaccgccaccgccagaaccgccgcca	Protospacer
 .***************************.**.  **  **.

114. spacer 3.5|1699049|42|NZ_CP018870|CRT matches to NZ_CP021767 (Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.786

aagccgccgccaccgccaccgccaccgccggagg----ggcgcccg	CRISPR spacer
ccgccaccgccaccgccaccgccaccgccggcggctgcgacg----	Protospacer
  ***.************************* **    *.**    

115. spacer 3.5|1699049|42|NZ_CP018870|CRT matches to NZ_CP045327 (Mycobacterium sp. THAF192 plasmid pTHAF192_b, complete sequence) position: , mismatch: 9, identity: 0.786

aagccgccgccaccgccaccgccaccgccggaggggcgcccg	CRISPR spacer
gagcctccgcctccgccaccgccaccgccggcagaacctccg	Protospacer
.**** ***** ******************* .*..* .***

116. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_017966 (Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence) position: , mismatch: 9, identity: 0.7

tagccgccaccaccgccggccggccggccg	CRISPR spacer
cgctcgccgccatcgccggccggccggtgc	Protospacer
.. .****.***.**************.  

117. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 9, identity: 0.7

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gccgcgccgccgccgccggccggccggaga	Protospacer
    ****.**.***************  .

118. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_024970 (Streptomyces aureofaciens strain CCM3239 plasmid pSA3239, complete sequence) position: , mismatch: 9, identity: 0.7

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gtacccccaccaccgccagccggccgtgac	Protospacer
  .** ***********.********    

119. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_KJ396772 (Streptomyces lavendulae subsp. lavendulae strain CCM3239 plasmid pSA3239, complete sequence) position: , mismatch: 9, identity: 0.7

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gtacccccaccaccgccagccggccgtgac	Protospacer
  .** ***********.********    

120. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_016624 (Azospirillum lipoferum 4B plasmid AZO_p5, complete sequence) position: , mismatch: 9, identity: 0.7

tagccgccaccaccgccggccggccggccg	CRISPR spacer
cgaattcgaccagcgccggccggccggcca	Protospacer
... . * **** ****************.

121. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP024986 (Streptomyces lavendulae subsp. lavendulae strain CCM 3239 plasmid pSA3239, complete sequence) position: , mismatch: 9, identity: 0.7

tagccgccaccaccgccggccggccggccg	CRISPR spacer
gtacccccaccaccgccagccggccgtgac	Protospacer
  .** ***********.********    

122. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to KT309034 (Mycobacterium phage Dante, complete genome) position: , mismatch: 9, identity: 0.7

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccaccaccgcccggccctgaa	Protospacer
. ************.*** ******    .

123. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_048850 (Mycobacterium phage Cornie, complete genome) position: , mismatch: 9, identity: 0.7

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccaccaccgcccggccctgaa	Protospacer
. ************.*** ******    .

124. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_021538 (Mycobacterium phage Job42, complete genome) position: , mismatch: 9, identity: 0.7

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccaccaccgcccggccctgaa	Protospacer
. ************.*** ******    .

125. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_026584 (Mycobacterium phage Minerva, complete genome) position: , mismatch: 9, identity: 0.7

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccaccaccgcccggccctgaa	Protospacer
. ************.*** ******    .

126. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to KJ409696 (Mycobacterium phage Lamina13, complete genome) position: , mismatch: 9, identity: 0.7

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccaccaccgcccggccctgaa	Protospacer
. ************.*** ******    .

127. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NC_028784 (Mycobacterium phage Tasp14, complete genome) position: , mismatch: 9, identity: 0.7

tagccgccaccaccgccggccggccggccg	CRISPR spacer
ccgccgccaccaccaccgcccggccctgaa	Protospacer
. ************.*** ******    .

128. spacer 7.1|2056232|32|NZ_CP018870|CRISPRCasFinder matches to NZ_CP030129 (Indioceanicola profundi strain SCSIO 08040 plasmid unnamed3, complete sequence) position: , mismatch: 9, identity: 0.719

cctgaggcggagcccccgctcttccgccccgc	CRISPR spacer
aaccaggcgcagccgccgctcttccgcccgat	Protospacer
  . ***** **** ************** ..

129. spacer 7.1|2056232|32|NZ_CP018870|CRISPRCasFinder matches to NZ_CP022305 (Thalassococcus sp. S3 plasmid pS3B, complete sequence) position: , mismatch: 9, identity: 0.719

cctgaggcggagcccccgctcttccgccccgc	CRISPR spacer
catcaggcgcaggccccgctcttccgcgttct	Protospacer
* * ***** ** ************** .. .

130. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to MN693542 (Marine virus AFVG_25M165, complete genome) position: , mismatch: 9, identity: 0.7

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
tccaccctgagaaggcgccggacaattggc	Protospacer
    ************ ********    *

131. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to MN693542 (Marine virus AFVG_25M165, complete genome) position: , mismatch: 9, identity: 0.7

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
tccaccctgagaaggcgccggacaattggc	Protospacer
    ************ ********    *

132. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to MN694128 (Marine virus AFVG_250M1142, complete genome) position: , mismatch: 9, identity: 0.7

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
gcaaccctgagaacgccccggacaaggtga	Protospacer
. . ********* ***********.*.  

133. spacer 20.1|7303545|30|NZ_CP018870|CRT matches to NZ_CP049029 (Fluviibacterium aquatile strain SC52 plasmid pSC52_1, complete sequence) position: , mismatch: 9, identity: 0.7

aggcccctgagaaggccccggacaaagctc	CRISPR spacer
cccgccctgagaatgccccggacataggaa	Protospacer
    ********* ********** **   

134. spacer 3.4|1698998|33|NZ_CP018870|CRT matches to NZ_CP029776 (Deinococcus actinosclerus strain Deinococcus actinosclerus SJTR plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.697

gggtaggacggacggtcaccaccacggtcgtca	CRISPR spacer
tcaccgaactgccggtcaccaccacggtcgtgc	Protospacer
  .. *.** * *******************  

135. spacer 3.5|1699049|42|NZ_CP018870|CRT matches to MK977696 (Gordonia phage SCentae, complete genome) position: , mismatch: 10, identity: 0.762

aagccgccgccaccgccaccgccaccgccggagg-----ggcgcccg	CRISPR spacer
atctcgccgccaccgccgccgccaccgccggaggtctccagc-----	Protospacer
*  .*************.****************     .**     

136. spacer 3.5|1699049|42|NZ_CP018870|CRT matches to MK977695 (Gordonia phage Pupper, complete genome) position: , mismatch: 10, identity: 0.762

aagccgccgccaccgccaccgccaccgccggagg-----ggcgcccg	CRISPR spacer
atctcgccgccaccgccgccgccaccgccggaggtctccagc-----	Protospacer
*  .*************.****************     .**     

137. spacer 3.5|1699049|42|NZ_CP018870|CRT matches to MK524490 (Mycobacterium phage Donny, complete genome) position: , mismatch: 10, identity: 0.762

aagccgccgccaccgccaccgccaccgccggaggggcgcccg	CRISPR spacer
tatccgccgccgccgccaccgccgccgccggaggcgtagtgg	Protospacer
 * ********.***********.********** *.. . *

138. spacer 3.5|1699049|42|NZ_CP018870|CRT matches to JN699007 (Mycobacterium phage Acadian, complete genome) position: , mismatch: 10, identity: 0.762

aagccgccgccaccgccaccgccaccgccggaggggcgcccg	CRISPR spacer
tatccgccgccgccgccaccgccgccgccggaggcgtagtgg	Protospacer
 * ********.***********.********** *.. . *

139. spacer 3.5|1699049|42|NZ_CP018870|CRT matches to MT889381 (Mycobacterium phage Suigeneris, complete genome) position: , mismatch: 10, identity: 0.762

aagccgccgccaccgccaccgccaccgccggaggggcgcccg	CRISPR spacer
tatccgccgccgccgccaccgccgccgccggaggcgtagtgg	Protospacer
 * ********.***********.********** *.. . *

140. spacer 7.1|2056232|32|NZ_CP018870|CRISPRCasFinder matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 10, identity: 0.688

cctgaggcggagcccccgctcttccgccccgc	CRISPR spacer
ctcatcatcgaccccacgctcttccgccccgc	Protospacer
*...  .. ** *** ****************

141. spacer 3.5|1699049|42|NZ_CP018870|CRT matches to AP013441 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G17, isolate: uvMED-CGR-C22-MedDCM-OCT-S33-C34) position: , mismatch: 11, identity: 0.738

aagccgccgccaccgccaccgccaccgccggaggggcgcccg	CRISPR spacer
ccacctccgccaccgccaccgccaccgccagagtttcctcca	Protospacer
  .** ***********************.***   * .**.

142. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP054615 (Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence) position: , mismatch: 15, identity: 0.5

tagccgccaccaccgccggccggccggccg------------	CRISPR spacer
------------gcgccggccggccggaggtggaggcggggt	Protospacer
             **************  *            

143. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP045310 (Micromonospora terminaliae strain DSM 101760 plasmid pLB1, complete sequence) position: , mismatch: 17, identity: 0.433

tagccgccaccaccgccggccggccggccg----------------	CRISPR spacer
----------------tggccggccggccgccggtggtccgctccg	Protospacer
                .*************                

144. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP045310 (Micromonospora terminaliae strain DSM 101760 plasmid pLB1, complete sequence) position: , mismatch: 17, identity: 0.433

tagccgccaccaccgccggccggccggccg----------------	CRISPR spacer
----------------tggccggccggccgccggtggtccgctccg	Protospacer
                .*************                

145. spacer 3.6|1699109|30|NZ_CP018870|CRT matches to NZ_CP013739 (Streptomyces globisporus C-1027 plasmid SGLP1, complete sequence) position: , mismatch: 19, identity: 0.367

--------tagccgccaccaccgccggccggccggccg	CRISPR spacer
tgggaggccggccgccggtggtgacggcga--------	Protospacer
        ..******. .. .* **** .        

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	7442 : 79194	57	Moumouvirus(25.0%)	integrase,transposase,protease	attL 5743:5759|attR 40620:40636
DBSCAN-SWA_2	1663965 : 1670909	8	Streptomyces_phage(28.57%)	NA	NA
DBSCAN-SWA_3	4198340 : 4255558	52	Moumouvirus(14.29%)	protease,tRNA,tail,plate	NA
DBSCAN-SWA_4	7505840 : 7577592	57	Bacillus_phage(25.0%)	protease,integrase,transposase	attL 7544399:7544415|attR 7579276:7579292

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP018870|7442:79194|DBSCAN-SWA
CGTGGACAGTGGGAGCGGGTTCGAGGCGGTGTTCCTCGACCCGGTGGGGCAGTCGGTGCAGCAGCGGTGGGCGGATGCAGCCATGACGGTGGCGTTCGAGGAGTTGCCGCCGGTGTCGGCGTTCCCGGTGGTGCCGGGGCGGCGTTGGGGGCCGGGACTGTGGTGGTCGGCGACCACCGGACGGCACGTGGCCGCGGGGTCGAACGCAATGCGCACCCAACTGATGGCCCTGGACCGCGACCCACGCGTGACCGGGCTCGCCGGGCGGCCGGTACGGCTGCTGTGGCGCGACGAACGGGGACGGGTGCGTTCCTGGGTGCCGCAGCTGTTCGCCCGCTACCGCGACGGCACGGGCCTGCTGGCCGACTGCCCCAGCCACCCCGACGCCGGTGGCGAACGTGCCCTGGGCGCCGCGCACGCGGTGGCCAGGGCGTGCGGGGACATCGGCTGGGCCTACCGGCGCCTTTCACCGCTCGACGATGTGCCGGCCTCCAATCTGAAGTGGCTGGCCGGCTATCGCCATCCCCGCAACGCCGGCCGCCCGGGCCTGACGCCCGCGGCTGTGGAAGCGTTCGCGCGACCGCGGCCGCTGATCGAGGGAGCCGAAGCTGTCGGTGACCCGATCGAGGTCCTTCCCGTCGTCTTCCACGCCCTGTGGCACGGGCAGCTCACGACGGACCTGGAGGCGCCGCTGCACGAGTGCGTCCCCGTCGGCCCCAGGGACTGGAACGGTCTGGGCCGGACGGGAGGTGCCGGGTGAGCGCGCGGCGCACTGCCCGGCCGGCCGTGGCGGTCGGGGCGCATGTCCGTTTCCGCGGTGTGAAGTGGCAGGTGGTCGCTCTGTCCGGACAGATGGTTCACCTCGTCGGCCCGGACGGCGGCGGTGAGGCGGTGCTTGCCGGGTACCTGTTCGCCGATCCCGGCTTCAGTGTCATCGGGGCGGAGGTGCCGCAGGCGGCCCCGCAGTGGGGGCTGTTCGAGACCGCGCCCGCCGCGGCGCGGGAGAAGGCCCTGGCCTGGCAGCGGCATGTCCGGGAAGTCGAGTGCGGCCTTGCCGACGGGCCCGGCAGCGGTGGAGTGGTGCGGGAGCAGTACGACCCCGCACGACACACGCTGGCCGAACGGGAGCAGGCCAAGGCCGAGGAACTGACCGCCCTCGGTTTCGGGCGGGTGTCACGTACCACGGTGCAGCGCATGCGCCTGGCCTACCGCAAGCAGGGACTGTGGGGGTTGCTCGACCACCGCACCACCCGCGCCTCCAGCTCTACCGGGCGCTCCGACGAACGGGTCGTCGCAGCCGTGCGTGAGGCGCTGCGCCGCCGGCGCGGGCGTTCCAGGGGCACCATCAACGGCCTGTTCCCGCTGATCCACCAGATCCTTCAGGACCGGCACGGCCCCGGTGCGGTGCCCGTGCCGTCCCAGGCCACGCTGTACCGGCTCGTCACCTCCCTCGCCCGCCCCGGTGAACTGCCCAGTGGCCCGGTGCGGCAGGTGCCCGCGAGCGTCGAGGGGCGGGCCTTCACCCCCGCCACCGCGCTGCGGCCCGGCGAGCAGGTCCAGATCGACACCACCCGCCTGGATGTCCTGGCCCTCTTCGACGACGGGCGCCTCGCCCGCCCCGAGCTCACCATCGCCGTCGACGTCGCCACCCGCGCCATCCTCGCCGCCGTGCTGTGCCCCAGCGCGACCAAGTCCGTGGACGCGGCCCTGCTGCTGGCGGAGATGGCCGTCCCGCACCCGGCCAGACCGACCTGGCCGGACATCCTGCGCATGGACCACGCCCGCGCGCTCCCCTACCAGCAGCTGGCCACGCTGGATGAGCGCCTGGCCGGCGCGGCGGCCCGGCCGGTCGTCCTGCCGGAGACGATCGTCGTCGACCGGGGCAAGGTCTTCGTCTCCGCCGCGTTCACCGCCGCCTGCGAGACCCTCGGCATCAGCGTCCAGCCCGCCCCGCCCCGCGCCCCCACCGCGAAGGGCATCGTCGAGCGCACCTTCGGCTCTATCAACGCCCTGTTCTGCCAGCACCTGCCCGGCTACACCGGATCCGACGTCACCCGCCGTGGCCCCGAGGCCGAGAAAGACGCCTGCTTCAGCGTCGCCCAGCTGCAGGACCTGCTTGATGAGTGGCTGGTGCACTACCACCACCGGCCCCATGAAGGGCTGCGCCACCCGATGATGCCCAGGAAGGCGCTCACCCCGAATGAGATGTGGGGCGCGCTCGTCGCCGTCGCCGGATACGTGCCCGTCCCGTTGACCGGGCGCGACTACCTCGAACTGCTGCCCGTGCGCTGGCAGGCCATCACCCCCGCCGGCATCACCATCCGCCACCGCACCTACGACGCAGATCTCCTCGCCCCGCACCGCGGCCAGGCCTCCCCCGTCGCCGGCCGCGGCGGGAAATGGGAGATCCACTACAACCCCCACGACGTCCGCCAGATCTGGATCCGGCTCCCCGACGGCGAACTCACCGAGATTCCGTGGATCCACCGCGACCACGTCCACCGGCCGTTCGACGAACACACCTGGCAGCACATCCGCACCCAGGCCACTGACTGCAACCACGGTGACGCCGAGCAGCACGAAGCCCGCCTCGCCGACGCCCTCGACCAGCTCATGCGCCGCGTCCACAGCGGCCACGCCACCAAGACCGAACAAACCCTCCTGGCCCGCACCGCTCACGTCCCACTCCCCACAGCCCGCAATGGGGCCCACGGCACCGAAGCACCCGCCGACAGCCCGGAACAGCGGGACGACGACACCATCGACGACCTCGACGACCTCGACGGCCTCGACGACCTGCCCGACGACGTCAGCCCCGCCCCGGCCACCGGACTCGGGCTCTACAACGCGCACGAGGAAGCCGACAAGTGGTGAACACCCCCCACCCCACGACGCCGAACCTGAGCCGCACACCAGTCGGCACCAGCGGCAGTGGTGCGGCCGAGCCATCCTGGCCGCTGACCACCTGGCAAGGCTGGCAGCGCTTCGCCACCACCGACCCCGTCGCACCGCCCCAGCCCGGCGATCCGCCCCGCAGTACAGAGGAACGCCTCGCCTACCACTCCAGCTTCGTCACCATCCGCACCCCCGCCATCCACACCCTGACCACCCAGGTCCGCACCCTGATGATCCTCGGCCGCCACCAGCAGAACACCGCACGGCCCTCACTGATCGTCACCGGACCCGCCGCAGCCGGGAAAACCACCGCCCTCCTCAACGTCGGCCGCACCTGCCACCTCGCCCACACCCGCAAAAACCCCGCACCACCCGGATCAGCCCACACCGCGGTACCCGTCGCGTATGTCCTGGTCCCGCCCGGCGCGACCGCGAAAACCCTCGTCACCGAGTTCGCCCGCTACCTCGGCATCCCCGTCACCGCGCGTATGACCCAGACCCAGATCACCGATGCCGTCTGCCACACCTACACCCAAGCCGGCGTCCAGCTGGTGATGATCGACGAGATCCACCGCCTCAACCCCCGCACCACCACCGGCGCCCAAACCGCCGACCTGCTCAAAGACCTCAGCGAACGCCTCCCCGCGACGTTCGTCTACGCCGGCATCAACGTCACCGACACACCCCTCTTCAGCGGGACACGGGGCGCTCAACTCGCCGGACGCGCCACCCTCGTCGACTGCGGCCCCCTCCCCGCCCGCCACGGCACCCGCCAACCCTTCCGCGACGCCATCACCGACATCGAAAACAACCTCGACCTCCAGCAGCACAAAGCCGGCACCCTCCCGGCCCACGCCCCCTACCTCCACCAGCGCACCGCCGGCCGCATCGGATCCCTCACCCGACTCATCCGCCAAGCCGCCATCACCGCCATCTGCGACGGCACCGAACGCATCACCAAAACCGCCCTCGACGCGGTACGACTCGACCACCTCGCCGAAACCCACCACCGCCCCCACCGACGCCGATAAACCCCACCTACCAAACAGACAGGCAGAACAGCCCTGACCAGCACAAACACCAACCGGGCCTTTACACGCCAGAACTACTTACAACGAACCCTGCCGCCCTCAACACGAAACACATAACCCCAGCTCACACACCCCAGCCACCCCGCCGAACCGCCAAATCCACCTCTCAACGAACCCACAACACCCCAGGCCACCAACGACCCGACACACCAACAAACCCCCCACCGAGCGTTACTCCTCGCGCTAGCGCTACCGGAGCATGGCCGGCCAGTCCGCCCCGGCATCAGCCTCAGGCCGTCGTCACACCGCGACCACACCCTCCCTCCGGCAACCGAAACCCAAGGCGCAGACCAGGCTCGGCTACCAGGGCCGCAGCGGCAACCCCGCCGCGCGCCTCGGCTCTAGAAAGTCCGTGCGGAAGATCTCCAGGGAGGCCCTGAGCAGCGGAATACCCACCTCCGCGCCAAGGTGCACCAGCGTGGCCGTCTCCTCGTCCATCCGGAACTCCAACAAGAGGGCGCCACGCCCGGCAGCAGTCATCTCCACCACTTCCAGAGCGTCGAAGTCGTCGCTCCCGAGCACTGTGAGGGCAACGTACTCCCGGCCCTTCACGGAGAAGAACCTCATGTTCGTCCCCTCCCGTGACCGAACTCCCGCGCCCCTGGCAGGCGCGGCCGGTGGGCCGGGACCGAGGCCTCGGCCGGGGCCGGCTGACCGGGGACCGCAGCGGCGGGCGTGATGGAGCAGGGACGAGCCATGGCCCGGAAGACCCACAGCCGGAACGCGTGCGCGGCGCGGGCGGCGCTCACAGCAGCGTTGCCAGCAAGTGGAGGGGCCCGTAGAGCACGGAGCAGGGTGCGCATGAGGAGGAGCCCTCCGAGCATCTGCAGCCAGAGTCCCGCGCCCGCTGCTGCTGCGTTGCCTGGCGGCCGGCCTCGTGCTGCGGGAGGTGCAGGACGCCCGAGCGCCACGCACCTGCCAGCACCACGGTCCCGGCCAGCAGGGTCAGGGCCGTGCCCACGACCTCGTACCCGGACCACTGCGCCCACCAGCCGGCCGTGGCCAGCACGAGACCCGCCAGCGCGCTGCCACCGGCCCGGCGCTGCCTGCCCGTCATCACCATCACCGCCTACGCCCCGCGCCCCTGACGGGTGCGGCCTGCTGCCGGTGGGTGGGGACCGCGGCCTCCGCCGGGGCCGGCCGGCCGGGGGCCGCGGCGGCAGTGGGGGTGGTGGTGGAGCGGGAGCGGGCGGCGGCCGCGGACACCCGGGGCCGGGAGGGGGCCGGTGCGCCGGGCGGGGTGGTCAGGGAGGTGAGGGTGGCGTCGACGAGGCGGCCGACCAGGGCGCTGCCGGTGGCTTCCTGCCAGGAGGTGGCGGTGGTGAGGCGGTTCAGGTGCTGGGCGACGGTGTCGGTGCCGTGATGTTCGCCGAGCTGCTGCATGCGGGGTCTCGGTGTCGCGGCGGTGCTCGTACTCCTGGCAGCGGGCCGGCGGATGCGGCCGGAAAACCCCGCCCAGGTTCGGAGGATTCTTGTCGTATCGCGGGCGAGTCGCATACGTTGACCTGCATGTATAGGGGGATGGAGCTAGCGGGCCGCTACCGGCTCGAGAGCCGGTTGGGGCACGGCGGCATGGGCGAGGTATGGGCGGCGTCCGATCTGAGGCTGCGCCGTACCGTCGCGGTCAAGACGGTACTCATCTCCCATCTGCGTGACGAACGGCTCGCTGCCCAGGTCCTGGCCCGTTTCCGCCGTGAGGGCGAAGCAGCCGCCCGGCTGAACCACCGCAACATCGCCGTCGTCCACGACCTGGGCGAGCACCGGGAGACGAGCGCCGACGGGCAGGTGGAAGTCTCTCCGTTCCTCGTCATGGAGTTCCTGGAAGGTCGTGATCTCGCGACGGTCCTGCGCGAGGACCACCCCGGCGGGCTCCCGCTGGAGCAGGTGGTGGAGTACGGCGCCCAGGTGTGCGACGGGCTGGCCGCCGCCCACACGCAAAACATCGTCCACCGCGACATCAAGCCGGCCAACCTCATGCTGCTCGACGACGGCACCGTAAAGATCTGCGACTTCGGGATCGCCCAGGTCCAGGACGGCACGATCGGCCTGACCATGACCGGAGCGCTGCTCGGCAGCCCTCACTACATGGCTCCCGAGCAGCTCAGAGGCCAGACACCGACGCACTCGGCCGACCTGTATGCCCTGGGTGCCAGCCTCTACGAGCTCCTCACCGGGCGCCCCCTGTTCACCGCGGACTCCGCGTACGCCATCATCGCCATGCATCTGTCCACCACTCCCGAACCGCCCAGCACCCGCCAGCCCGCAATCCCGCCCGACATCGACAACCTCATCACCTCCCTTATTGCCAAAGACCCCGCCGGCCGTCCCCCCACCGCCAAAGACGTCGCCGCACGCCTGCGCACCGCCCACCTCGCACCCGGGCCCACCCCCGTGCCGGCAGCGGAGGCGTCGGAAACCGACGAGCAGCTCCTCCAACGGGACGCCGAAGCCGGAGACTCCGACGCCATGTACAGCCTCGCGTGGCTGCTGCAAGAGGCTGACCGCATCGACGAGGCAGAAACCTGGTACCGGAAGGCCGCCGACGCCGGACAGATCGACGCCATGAACAACCTCGGCGTGCTGCTGGAGAACACCGGCCGCACCAACGAAGCAGAAACCTGGTACCGAAAAGCCGCCGACGCCGGACAGATCGACGCCAGGAACAACCTCGGCGTGCTGCTGGAGAACACCGGCCGCACCGACGAGGCGGAAACCTGGTACCGGAAAGCCGCCGACGCCGGAAACACCGACGCCATGAACAACCTCGGACTGCTGCTGGAGAACACCGGCCGCACCGACGAGGCAGAAACCTGGTACCGGAAAGCCGCCGACACCGGAGACACCGACGCCATGTACAGCCTCGGAGTGGTGCTGGCCGGCACCGGCCGCACCGACGAGGCAGAAACCTGGTACCGGAAAGCCGCCGACACCGGGCACACCGACGCCATGACCAACCTCGGAGTGGTGCTGGCCTACTCCGGCCGCACCGACGAGGCGGAAACCTGGTACCGGAAGGCCGCCGACGCCGGACAGATGAACGCTACGGCCAACCTCGGAGTGGTGCTGGCCGGCACCGGCCGCACCAACGAGGCAGAAACCTGGTACCGCAAAGCCACCGACGCCGGAAACACCGACGCCATGCACGGCCTCGGAGTGCTGCTGGCCAACACCGGCCGCACCGACGAAGCAGAAACCTGGTACCGGAAAGCCATCGACGCCGGAAACACCGACGCCATGAACGACCTCGGAGCGCTGCTGCATAACACTGGCCGCGAGACCGAGGCGCAACCCTGGTTCCAGCGCGCCGCCGAAGCCGGACACACCAACGCTATGAACAATCTCGCACTGCTGCTGCATAACACTGGCCGCGAGACCGAGGCGGAACCCTGGTACCGGCGCGCCGTCGACGCCGGAAACACCAACGCAATGAACAACCTCGCACTCCTGCTGGAGAACACTGGCCGCGAGACCGAGGCGGAACCCTGGTACCAGCGCGCCGTCGACGCCGGAAACACCAACGCAATGAACAACCTCGGCATGGTGCTGGAGGACGCCGGCCGCACCAACGAGGCAGAAACCTGGTACCGAAAAGCCACCGACGCCGGGAACACCGGCGCCATGACCAACCTCGGACTGCTGCTGGAGAACACCGGCCGCACCAACGAGGCAGAAACCTGGTACCGAAAAGCCACCGACGCCGGACAGATCAAGGCCATGAACAACCTCGGGGTGCTGCTGCAGACCACTGGCCGCGAGACCGAGGCGGAACCCTGGTACCAGCGCGCCGCCGACGCCGGAAACACCGAAGCCATGAACAACCTCGGAGTGGTGCTGCAGGGCACCGGGCGCACGGCCGAAGCAGAAACCTGGTACCGGCGCGCCGCCGAAGCCGGAAACGCCCCTGCCATGAACAACCTCGCACGGCTGCTGCAGAACACAGGGCGGGCGGCCGAGGCAGAAACCTGGTACCAACGCGCCGCCGGCAACCCTGACGGTGAAATCCGGGCCTGACCGGCCCCCGGCGCATCCGAGGCTGCGCCGGGACCACCCTCAGCCGACGAGCCCCTACGCGCTTGTCACGCTTGCCACGCTTCCTCGCCCGAGCTGTGCGCAGCGCAGGCCGCCGCCCGCGTGCCAGTCCAGCACTGGGGGGCGCCTCGCCGCCGTGTTCGTCGCACCACAGGACTGGGTCCAGGCCGCCGCAGTCGTGGCGGGTGCACACGCAGTCCTCGCCGGTCCTGGTCTGCGGGACGCCGTGGCGACCACACCACCGTTACCGGTGTGCGCGGTGGTGCCGCGCAGGCGGGCCGGCCATTCCAGCGTGATTCGCAGGCCCCCAGATCCGGACCAAAGCCGGTCGGTCACCCGGACGTCCCCGAGCACCGCGAGGGGACCCGCGCCCGGTGCGGTGAGCCGTGTCAGGGTGGCCCCGACCGGGCCCGCCGCGAGGGCGGCCAGCGCGTCGGCGTCCGCGTCGTCGGCGACCCAGCCCGACAGCCGGTCGGTGCCCTCGATGTCGTCGGCGAGGCCCAGCCACGGGGCATCCAGCCGGAACCTGCCTGTAGCGCCCCTCTCGCCGCGCACCAGCAGCGACGCCTGCCCCGCACCGGCGGGAAGGGTGATCTTGTCGTGGGCGAGCAGCCAGTTGACGACGTCGGCCCGGTCGAACTCCGGATGCAAGTCCGTCCCGGCGGCCTGGGCGGGGCAGCAGGTGGACGGCCGGGAGCCATGCTCTAGACGAGTAAGTCCGAAGTCTTCGGGCGCATGAAGCGAGGGTCTCGTTGATCCGTTTGTGACGACAGATCTCGAAACCCTCGCGACTGCACTGTACGTGAGGATTGATGACTCTCTGGCAGGAACGCGGCGATGGGGCCGTCCGCCGAGGCTGACGGATGCCGAGCTGTTGACGCTCGCGGTCATGCAGGCCGTCCTCGGCTTCGCCTCCGAGACCCGCTGGCTTCGGTTCGCCCGCCGCCACCTGAGCGCCGACTTTCCCCTACCTGCCCGAGCAGTCCGGCTACAACAAGCGCCTGCGGGCCGCCAACACGCTGATCAGCCGGTTCATCCGCACTCTGGCCCGCGACACCGACCTGTGGCACGACGACGTATGGATCGTGGACTCCACCCCCGTGGAGTGCGCCCGCTCACGGCCGACGGTCAAACGCTCGCAACTGGCGGGCTGGGCCGGTTACGGCTACTGCGCCTCGCACTCACGGTTCTTCTGGGGCTTGCGTCTGCACCTGCTCTGCACACCCGGCGGCCTGCCCATTGCCTGGGCGCTGGCCAACCCGACAACGGACGAGCGTGAAGTCCTCGCCGGCATGCTCACCCAGGACATCGACCTGCTGGCCACCCACCCCGGGCAGACCATCGTCGGCGACAAGGGCTACGTCTCCAAGCACCTGGACGCCTTCATGGCCGACCACGGCCTGACCCTGCTGCGGCCCAGCTACCGCAACCGCAAGCCACGGCCGGGCGAGCACCTGCTCAAACCGATCCGGCAGCTCATCGAGTCGGTGAACGACACCCTCAAAGGCCAACTCGACCTCGAACGTCACGGAGCCAGAACCCCATCTGGGGTCCTGGCCCGCGTCGGACAACGCATCCTGGCCCTGACCGCAGCCATCTGGCACAACCGGGCCAACGGAACATCCATCACCCGATCACTCGTCGCCTACGACCACTGACCAACACTTCGGACTTACTCGTCTAGTTCGACGACGAAAACGCCGACCACCACGACGGCACCAACAGCCGCGTCCACACCTGAGCCCATCCCGTCTGCGCCCGCAGCGCGGCCCCGGTTTACCTCGTCCACGGCCGGACAGACGCCCACCAGGGAGCCGTACAGCACCCGCCGCGGCTCCCGGAACAAGGGCCCGGCCACCCACCTCTTCCCGGCAACAGCACCGGCGGGGCCCCGCCCCACGGAATCCCACAGCACACGCCCGCTCCAGCCGCCTGAGCGGCCGACGGCGGCGCCAGCCGGCGCAGCTATCGCGGGCCAGGGACCGGCAGCGTGTTCCGGGCGTTGTACTGCTCGACCCACTCGACAACGTCGCGGCAGCCGTCCGGCGGGAAGGCGACATCGGGCACGAGCCGGAGCGCCTCGGGGATGTCCGCGCCCGGATGCGTCTCGCGGACGTGATCTCGGGCGCGGGCCAGCGCCTCGTCCAGCCGTCCGCTGTCCAGGACCAGCTCACCGAACGCGCCGCACAGGGCGCACCGGACGTACGTCGCCTCGACCGCGGTCCGCATCCCGAACGGCAACCGCTCCACCATCTCCATGCCCTGCCCAACGCCGCCGGGTCACGCCGGACACCAGCAACACGGGCGGCAGTAGGGGTGGGGGCGGCCCGGGGGTACTGCTGCCCCCAGAGCGCTCTGGGCCCCGGGCTCACCCGAGCACGCCATATCGGCACGGGCTACCCGGACCCTAGCTTGATCGGCAGCGTTCATGCGGGGTTGCCAATCCTGTCCGGTCGCCTGGCGCGAGGACGGCATGGAGGGCTTGCGGTCAGCGGGTCCGGCGAACGCCCCGACCATCACCGACGAACAGTTCGCCGTGCTCGAGGAGGAACTCGGCAAGGGCCCGTCGGCGCACGGCACAGCTATGAAGACGAACGCTGGACCCTGCCTCGGGTCCAGACGTTGATCTGCCGGCATCTTAACGACAAGCCCTTCGCGCCGTACACGACGAGCCTGGCCCACTCGCACTCGGGCTGCCGGAGCTGGTGCGGCTGTGCCTCGTGGCGCCGTGGTGGCGAGACGCTCCCGGGCGGACGGCCGAAGAACTTCTAGCGGTCGCCGACGAGTACCGGGAGGTCACGACGAAGTCGGCCCAGGTCACGAGGCTGCCCCCGGACCCTGCTCGATGCGGTCCAGCAGGGGCTCCGCCCACTTCGGGAGGGCGGACGCCGCCGGGCGGGGCGGGCGGGGGTCGGAGGTGATGCCGAGGCCTCCCGCCGGGTCGCCGTACACGAACCGCTGGGACCACCCCAGCCAGGAGCGGACAAACAGGTTCGCGCTCCACGCCAGGGCCAGCGCGCCGCGCAGCCCGGGGACCTCGTACCAGTAGCTGGTGAGCACCACGGCGCGGGAGACCGCCTTGTCCGGGTCCCCCGGCCGGGAATCGGCGGTGAGCCCGGCGGCCAGCACCGATGCCGCGAACCGATTGTCGGCGAGCAGCCCGCCGCTGTCGCAGACGACCGCGTCCAGCAGGTCCGCCGGGAGGCCGGCGGCGGCATGCTCCAGCCTCGCCAGCAGCGCGGGCAGGCCCGGCTCGCCGACCGCCTCCGGGTCGGGAACCACCCTCAGGTCGGCCGGCAGCCGCTCGTCCCCCGTGCGGGCGGCCAGCAGGTGCACGTACGCCAGCGCGCGCAGGGTCTGCCAGCGGCAGAGCGTGTCGAGCAGCTCGGTCCGGGAGTTGCGGAAGGCGAGCCGCACCGGCCAGTCGGCCGCCCGGACGTCGTTGCCGAGCGCCCGCAGCTCCGCCGGCAGCGGGGCCGGGAAGACCCGGCTCTGGCCGGGGTCGTAGGACGGCTCGGCGTGGTAGCCCGGCCAGCCGGGTGCAGGATCGCGGGGGATACCGCTGCGGCTACTCATTCACTTCGTCCCCCTTCGGGGTCCGCCACTTCGCGGTGTCCTTGCCGTCCCGCGGAGTGATGTAGTTGGAGAGGTCCTCCGGCTCGATGTGGTACGCGTGGATCATATGGTCCTGGCGGATGATGGCCACCGGCCTGGACGGGTCCAGGGTCTTGTCGATGATGATCCGCGCCCCCGTGTCGCTGTCGACGTAGTTGGCCGGCGATTGCAGATGGCCCCGCAGGTACTTCTCCAGTTTCACCTCGTCTTTCCCGATGCCCTGCAGGTAGTGGTTGTCCTTGCCGCTCTCCGCCTCGTTGAGCTGGTGGTCGACGCCCTGCGCCGCCCGGGTGCTGTCCGAGTACGGGGCCAGCCCGAAGGGGTCGCACCACCCGTGGGGGTTGGCGACGTACGCCACCGGGTTGGGGGCCGCCGCCAGGCCCAGCGGGTCCGGGCTCAGGTAGCGGGCGGTCTCGGGGTCGTACGTGCGGAAGTAGTTGTGGTGCAGGCCTGATTCGGCGTCAAAGTACTGGCCGGGGAAGCGCAGCGGCGTGTAGGCCGTGGCGTCCCGGTTCCAGGCCGTGGATCCCCACAGTGTGGAGCGGCTGCGCCAGGCCAGTCCGCCGCGCTCGTCGACGAGTTCGGCGGGTGCGCCCACCAGGTCGGTGACGATGGCGTAGAACCGCTCGTCCACCACCTCCTGGCTGGCGCCCAGGATCCGCTCCGTCTGCGCGAGCGGCTGCAGGCCGCGGTGGTCCCAGGTCACGGCGATCCCGCCGGCCTCCTGCGCCGCGGCGGCGGTCCGCTGCTCGCACAGCACGGTGCCGTCCCAGGTGAAGACCGTGCGCTCGGCCACCTCCAGGCCGTCGGGCGTCATCCGTTCCTTCGCCGTCCGCCGTCCCAGCGGGTCGTACGTGTACCGCCAGCGCGTCCCGTCCGGGGTGGTGACGGCCGTAATTCGGTCCTCGGCGTCCCACTCGTAGCGCCAGGTGTCGGGCTTGCGCGAGAGCCGGGCCTTCTGGCGGAGCACGACCCGGCCGAGGACGTCGTACTCGTGGCGGACCCGGCCCGCGCCGATCAGCCGGGTGCCCTCGTAGGTGCGCGGTCCGGTGGCTTCCCCGCCTCCGGGATGGGCGCCGGGCCAGTACGCGGAGGTCTGGTTGCCCACGTCGTCGTAGGCGTAGCGCTCGGTCCAGTTACCGGCGTGCACCGCCGTCACCCGGCCGCGCGGGTCGAGGTCGAAGCTGCGCGGGCCGGCCAACAGATCGTCGACGCCGGTCAGGACCCCGTCGGACCGGTAGGTGTAGCCGCGGCGCTGCACCACCCCCTGTCCTGCGCCCGTGAGCCGCTGCTCCACCAGCCGGCCGGTCTCGTCCCACGCCTGGTCGAGGGCGACGGCGTCGCCGTAGGTACGGCTGAGCTCCTGGCCCGCCGCGTCGTGCGTGAAGCCGATCCGGCGGCCGGACGTGGTCAGGGCGTCGTAGCGGCCTGCGGCGTCGTACGCCCAGGCGGCGACGGCGCCCGTGGGGGTGGTTCGGCCGGTGCGGCGCCCCATGGCGTCGTAGGTGTAGGTGAGGGTGCGGCCGTCGACCGTCTCCTGGAGGATGCGGCCCGCCCGGTCCCGCAGCCGGGTCAGCACGCTGTCCCCGCACACCGCGACGGCGAGCCGGTCGAAGACGTCGTACTCGTACGTCGTCACCGTGCCGCCCGCGTCCTTGCGGACGGTGCGCCCCAAGGCGTCGCGCTCGTACGTGATCCGCTGCCCGAGGGCGTCGGTGCGGGTGACGAGCCGGCCCGCCGGGTCGTAGGCGTAGTCGAGCACACGGCCGTCGAAGTCGGTCTCCCGGATGAGCCGGCCCGCCGGGTCGTAGGTGTACTCCCAGGTCATGCCCTGCGGGTTGCGGACCCCGGTCAGCCGCAGCTCGGCGTCGTATGTGTATGCGTGGCGCGTGCCGTCCGCGTCGGTCCGGGCGGCGAGCAGGTCGAAGTGGGTGTACTCGAAGTGCACCCCGCCGCCGTCGGGGCCGTCCGTACGGGTCAGGCAGTTCCCCTCGCCGTCATACGTCCACGAGCGGCGCCGGCCGTCCGGGTCCGTCCGGTGCAGCGGCTTGCCCTCCACCGTCCATTCCATGCGGGTGACCGCTCCCAGGGGGTCGGTGACCGCCGTGACCCGCCCGAAGGCGTCCCGCTCGTACGTGGTGGTGGCGCCGAGCCGGTCGGTGACGGCGAGCGGCAGCCCGGCCCGGTCGGTGCGGATCCGCGTGACCGCCCCGCGGGGGTCGGTGACGGTGGTGAGGTGGCCGCTCTCGTCGTAGCCGAAGTGGGTGACCGTCCCGTCGGGGCGGCTGACCGCGGTGCGGTTTCCGCGCTCGTCGTAGGTCTGGTGGACGACCGATCCGTCCACGGCGACGACCTTGACCGGCCGGCCGAGGTCGTTGTACTCGGCGCGGGCCTCCCTGCCGTCGGGCCGGACGTAGGAGACCATGCGGCCCGTGTCGTCGAAGGTGCTGCGGGTGGTGTGGCCGAGCGGATCGGTGAGCGCGGTCCGCCGGCCGCCGCTGTCGTACTGGTACCGGGTGACCGCGCCGAGCGGGTCGGTCTCGGCCACCACCCGGTACCGGTCGTCGATCAGGTACTGGCGGGTATGACCTGCGGCGGTGGTCACACGCGTCACCCGGTGGCGGGTCTGCGGGTCCACGTCGTCGTAGCGGAAGGTGAGGGCGATGTGGCCCGCCTCGCCGGCCTCGGCGACACACCGGTCGAGGTCGTCGTAGGCGTACTCATAGCGGCGCTCGTTCGTATCCGTCCAGGAGGTGATGCGGGCGCGGTCGTCGTAGGCGAACCGCAGAGGCAGACCGGAGGAGTTGGTGACCTCGGTCAGGTTCCCGTCGGTGTAGCCGTACGCGAGGACGCGGCCGCCGCCGGACAGGTGCAGGGCCGTAATCCGGCCGCCTTCGGTCTCGAAGTGCAGCCGGTAGCCGCCCGAGTGGGTGAGCCCCAGCGGCGTGCCGTGCTCGTCGTACTCGAAGACGACGTGGTTGCCGTTCGGATCCTCGAACTGGGCGATCGGCGCGATGCCGTTCTCGGCGCCGTCGGCCGGCGGGACGAAGCGGCGGACGGCACCCGTCAGCGGGTCCGTCAGCGTCCAGTCGCCGTCAGGGGTGCGTGCCAGCGGGTGGCGCGGGGCCGAGGCCGACACCGGCAGTACGGGCACACCGGGCGCGGGATGCGGATAGCCGACGAGGAGGCCGTCCTCGGAGACCAGGACGACGCCCTTGGCGTCGATCTCCAAGTGCTGGTCGATCGTGGAGGACCAGGTGGGGCCGAACCAGCGGCCCGCCCGGTAGCCGGACTCCGCACGGCGCGTGAACGCGAACGGGAACGTGCCGGGCAGGACCACGTCCGTCTGCGGGAGGTACATCCGGCCGGTGGCGAGGTCGACGGGGTCGGTGCCCTCACTGGCCTTGTCCGGGTCGGGCCGCTCGCCGTGGTGCGGTCCTTTCCCGTCCGTCTCCTTGCGGCCCGGGCCGTCCGTCTCCTTGCCGCCCGGGCCGTCCAGGTCGTCCAGGTGCTTCGCGGCCGTGCCGGCCTTCTTCCCGGCGCCGAGGCCCTTGGTGCCGGCGAGTTCCGGGAGGAATTTGCCGACGCCTTCGGTGGGGTCCTTCATGAAGTCGTCGAGCATCTGCTTGCCCGTGCCTATGGGGTCGTTGACCGCCACGAGCAGGCCGGCGACCGTCGAGTTGAGGTTGGTCCGGTACTCGGCGGGGTGGGTGAGGTTGTACGGGTCGAACGGGGTGACTGCCCGGACGAAGTTGGCGAGGCCCGCCGTTCCCTTGAGGACGCCCCCGGCCAGGTGGGTTTCCGCGATCTCCAGGTAGTCCATGCCGTCTTTGAGCTGTTCGGCGTACGAGGGCTTGGGCGGGGCGGCGTCGCGGGCCGCGCGGACCGCCGTACGGGCCGTCTCCGCGACCTCGTTGCGCTGGGTGCGCGCGGTCTGGAGCTTGTCGTCGGCCGCCTTGAACAGCGGATCGGCGGGGTCGGTGAAGTCGTCGGCCGGCCGCGGCGGCAGCGTGTCCTTCTCGGCCTTCACCGCCGCCTTGTAGTCGATGATCGACTTGTTGTAGGCGGTGCGCGCGTCCTGAGAGACCTTCTTGGCCCTGTTGTACTCCTCCAGGGCCTCCTTGGCCTGGCCCTGTGCCCACTCCACGGTGTCCGCGAACCGGTTGATCGCGTCGGCGGCCTTGCCGAAGGCCTCGGCCGCCTTGAACCAGCGCGGCGGCTCCTTGGCTATCGCGTCCCGGAACGCGTTCGCCGACGCGCCCTTCAGGCCGTCGCCTTCCAGGGCCTTCAGGCCGTTGCCAACGAGTGTGAACGAGAGCTCGAAGTCACTGAGGTGCGAGACCTGCGCGCGGATCTTCGACACGCTGCCGTAGACCAGCTTGTTCGGGTCCTCGGTCTGTCCGAGCTCCAGCTCGGAGACGTCCGAGCCGAGCTGGTTGGCGGCCGATCGGCTCTTGTCACGGACCCAGTCGCCCGCCTCGTCCAGGCCCACCTTCTCTGCCGCGCCGGCGACCTTGTCACCGCCCCACTCGACCGCGTCGCCGAGGTCCTCGGCCCGGTCCTCGACCCAGTCTTCCGCCGAGTCCGGTACGAAGTCCCTCCAGCCCATCAGTTACCGCCCCCGCCGGCCTGGTCCAGCAGATCCTTCAGCGATCCGATCTTCCCGCTGGAAGTCAGCTTGTCGCCCGTGTCCGACCAGGTCTGCTTGATGTCCGCGTCGCTCTTCTCGAAGGACTCATCGCTGTAGTCCGGCTTGTAGACATCCGCACGCCAGATGTCGTCCCAGCTCTTCTGCTCGATCTCGTCCTCACTCGCATGCGGATTGCCGTACGCGGCATTGGCGACCACCTTGAACGCCCCCTGCATGTAGTGCTCTTCCTCCCACACCGTGCCCGCCGCGATCCCCAGGTTCCCGGCCAGAGCGCTCGCGTTCTGCACCAGACTGCGCACGCCCCACTCCCAGCGCTCACAGAAGTCCTCGAAGTCGGTGGCCAGACCCGCGTGTCCGGCCTCCATCCCCGTCATCGACAGATCACTGAAACCGGCGCCCATCGAGGCGCCGGCCGCATCCCCGGACTCGCGCAGCTCGGCGACGGCCCTGCGCAGACCGTCCTGGATGTTCTTGACCGCAGCCGGCGAAACCTCAAGGTCCGCATCGCCGGCCATCAGACGGCTTCCGCACGGTCGGGCCCTGCATCCACGGCATACGCGTCCGGAACGATGCCCACGACCGGCGGGAACAGCATCGAACCGTCTTCATCAGCGACATCGACGGCCACACCGGTCGGACCCTCGACCGTAGGGATCACCGCGTCGACGAGACGGGCCCCCAGGATCGAGAGGTACTCCCACTCACGCGCACCAGCATCAGCACCGCGCGCCACCGCGAAACGGGCCAGAGCCTCCTCGTCCGTGAACGCGTAAATCCAGCGCACACCGCCCTGCCACCCCGACATCAGCCCGCCGCCATCACCCTCCGACAGCGGCACCAGCAGTGCGGCGCGGCGAAATTCCCCCAGCAAGCGGCCCGAATGCCCCGATACGCTGCGCACGGCGGATATCTCCTCGGCCAGTCCCATGAAGTGCCCCCGTTCTCCGAGGGCGCCCGACTCGACAGCCCCCAGTTCGCACACGCTACCCAATCGGTCAGCCCCCACCGAGCATCGGCCCCTCCTCTGTCCGATCGTCCGTTCGACGCCGGGGGAAGTATCACGAAAGCGGCTCTGGCTCACTTCCGGTGGTAACGGGGCGTGGTGATCGTTACTAGCGGCGATTAACGCAGGCCAAGTGGAAGGTCGATGCCTTGGCTCTGTGCCCGCCGAAGACACGGACAGGGGTCTGACACGGACAGGGGTCTGACACGGGCGCCTGCTCGGCTCAACAGGCCTTCTTGCCATGCCTTTCCGTCACCACCGGAAGTGAGACAGAGCCACGAAAGCGGTGTTCACCACTCGGTTGGCGTAGAGGTTTCTCGTTGGTCTGGTTGGCTCACACTCGTTCGGCGGAGAGGCGGCCGTCGAAGGCGATGTCGAACGCGTTCATCGCCTCTTTCCAGCGGCTGGTCCACCGCTTGCGGCTCTTCCCGGTGGGGTCGAGGGCGAGGGTGGTGAGGTAGAGCTGCTTGAGGGCGGCGGTCTCGTTCGGGAAGTGCCCGCAGGCGTTGACCGAGCGCCGGTAGCGCGCGTTGACCCGCCCGCGCGTTTCGCGCGGACCGCTGGGCGGCGAAGAAGGCCGCCGCGCAGGCAGCGCTCGCCGTCGCCGCGTGGGACTACCCGCTGCTGGATGAGCACGACTTCCTCAAGACAGTCCACGGACTGGTCCACACGGCCGTGGCGGCCGGCGGGAAGCGCCTCAGCGTCCACCTCGCCGACCAGGACGACAAGATTCTCGTCATGGCTCTCAACCACCAGACCCGTGAGCAGGACGCGGCGGGAGCCGTGCCGGCGGGGGTGGCGGTGCTGCGCACCGTGGACGCGTGCGGCGCCCATACCGACCACGACGGCCACGCCTGGTGGGCGCTCCTCGACGCCCGACCCGCTCCGAAGAAGCGCCTGGCATAGCCAGGGAAGCTGAGTTCACCCTCGGCCGTGAATGCGGTCGTTGGGCCGGGGCCGGGTGGATGCTGTCGACCGGGGCGGTGACCAGCTATGTGTGACAGCGGCCGGGTTCCTGCCCGCGGTCGACAGCGCCACGGGGGCCGGGAGCGGCCCGTCCGAGAGCAACTCCCCGCAGCACCATTGCACCCTTTTCCCGAGGCAGGCCCGGTGTTGACGTGCGGACATGGGTGTGAGCCGCACCCGGACAGGTGCTCATGGTCCGGGTGCGGTTCTACCGGGGCGGGCCTGGTGGCGGGTGTCAGAAGGAGACGTCGAAGTAGTCGATGTCGGTGAACTCGACTCGGAGTTCGTCTGCTCGGGTGCCGCCGTCCTTGAAGTAGATCTCCTGCAAGCCCTCGGCGACGATCCCGCGCAGATCACGGTCGTCGGCGCCTCGGGCGCGGGCGTCGAACAGGCGCTGGGCGTAGGCGGGCGGGAGGTGGACGGTGAGGCGGCGTACGCGGCCGTCGTCGGTGGTGCCGACGGGGGCGGTGTAGCCGAAGCGGGCGCGGGTCTCGACGGTGATGCCGGTGCTGGTGGCGGCTTCCTTGCGGCGGCGGCCGCGTACGACGGGCTGCCAGCGGGCGCGTACGGCCGCCTCGATGCGGGTGGCGACAGGCTGGGGCGGGGTCTTGCGGTCGCCCTTGCGGTAGCGCTCGACGGACCGCTGGCTGACGCCGAGTTCGGCTGCGACCGCGCGGGTGGTCTTAAGCTGCTTGAGCAGGAAGTTGATCTGGCCCTTCAGGGTCTTGGGTGGGTCCTTGGTGAAAGCCTCCTGGTCGGCGCGGAGGATGGCGTCCTCGATCTCTCCCACAGCGGTTCAGCGCTCCTGACAGGTGTCCGAGTCGTACACGGTGAGCGGTCTGTCAGCCGTGGCCTCCGGTCGCGGAGGCCACGGCTCGATGCTATTCGCCGTCGTCGAGGACAGCGTCGCCGCCCTTGATGTGGCGGGCGGGGTTCAGACCCTTCTCCATCAGGTCCACCGCCCACGCCAACTGCTGCACGCCCTCCAGCTTGGCGAGGCCGGGGGTGGGGCCGAGGCGGAAGCCGCCCATCAGCGGCTTGCCCGACGCCGCGTACGGCAGGAAGTCCAGCGGCGAGGCGCCCGGGGACGGGTAGACGACGCAGTCGGAGAGCACGGCGAGGGGGTACAGGCCGGTCAGCTTCACCATGTTGGCGAGCTTGCGGTGCATGTTGACCCGCGCCTTCGAGATCACGGCCGCGCGGATGTCGGGGCGCCAGGTCGGGCGCTGCATGGCGGGCCAGGGGTCGCCGTCGCGGTAGGTGCGGCCCTGGGGCCGTTCGCGGAGCTTGCCGATACCGCCCTTGACCGTCGCCTTGATCGCCGCGAGGACGGCGGCCATCGCGGGGTCGGCCTGCTTGTGGTGCTCCATCGCCGCCAGGAACTCGGCCTCGGTGAGGTCCGGTGACGCCGAGGTCGGCCAGGGTGTCGACGTACGCGGTCTTGAGCCGGTCGTGCCACGGGTCGAGGTAGGCGCCGGTCTCCCGGCGCAGGTAGGCCTCGATCGGGTGGACCTCGTGCCCGAGTTCCTCGGCGTAGGCCAGGGTGTGGGTCTGGTACCAGGCCGGGCCCGTCGGCCGGGTGCCGTCCGGGGTGAACGGCGACGGCAGACGCGGATCGAGATCGATGTGGGAGAGGTCGGCCAGTCAGGAGCCGGGGATCTTCTTGTTGAACACCGGCCGGTGGAAGTGGTCCGGCGCCGACAGGCCCACCGTCAGTCGCGCCGCGGCCGCGAGGAACGCCGTGTTCAGGTCCAGGCCCACCGCGTACGGCAGCAGGCACTCCTCGTCCGAGAGGAGGCCGGGGTCGCGGACCCACTGGTACGCCTCCTCGTTCAGGAAGCCGCCCGTCCAGCCGGAGTTCACCACGACGGGGTGTTCGGCGATCGCCTCCGGCGGCGCCGGGTCCATCGGCTCCGATCCGAGGCTGCCCGGGTTGTGGCCCGACACCCAGGTGCCGTTCTCCTGCACGGCCCGGGTGGGCGGGCGCAGCGCGGTCATCAGCTCCAGCCCGGACACGGCGGTGGAGCCGCGGGGGGTGATGACCCGCTGCGCGTACGCGCCGAGGACGCGGGCAATGTCAGCCGGAGCCATGTCGGCGACACCCGGCCAGGAGCGGGTGTCGAGGGCATCCCAGGACAGGACCGCGAGCTGCACGCACTGCCGCGCGCTCCCCTGGGCCTTGCGGTAGATCCGCGGCCACGGGCCGAAACCGCGCTGCGTGAGCTGCCACTTCGCCCTGGCGATCTGCTTCACCACCGGGTGGTCCTCCGCCAAGCGCAGCGAGCGCCGCTCCTCCCGCCCCTCCAGCCGCTCGGGAAGGCCTAGCTTCACGGCAGCGGAGGCGGTGAGCACGATCAGGGGGTCGGAGTCCTTGCCGCTGCGGTTCAGCCGCGCGGCGCCCAGACCGGACTCCTTCAGCGTCCACTCCACCAGCTCGACCACCGTGGTGGCCGGGCAGTCCACCACGATGCCGTTCACGGCGTACGCGTTGCCGTCGCCGTCGAGGACGGCGAGCGGACCGTGGGCAAAGCGGGGATCGGCCGGGTTGGTGGCGGGCTTGGCAGCCTCCTTCGCGGCCGGGCGCCGTGACGAAGCCGCCGGACGGATCGGGACCTCGGCAACGGCCGGGCTGACGGGCTCCGCTGACGGAGCGGCCGGAGCGGGCGTGCCGGAGAGCGCGGCGGGCACGGGCGTGTTCGGGCGGGTGGGCTGCTGGGCGGCCCAGCCATCCAGCAGCCGCTGATACGCCTGACGGCGCGGCGGGCGCGGCTCGGAACGGCCCGCTTCCCAGTTCTTCACCGACTGTGTCGTGGTCTGCAGGACCTGGGCGAGACGCGCCTGGGTGACACCGGCCGCCTCGCGCAGCCGGGCCCGCTCGGCCGGCTGCGGCATCTCGGGCTCACCGGTCAGCAGGGCATCCACGGCCGCGAACAGCTCATCCTCGGTTGGCATAGGCCAACCCTAGCGTGTCTTAACCTCAGATTCCGGCACTTCTTAACCTTGGATTTAACCTCGCGGGACTTCGGGACGCGAGAGCGGGTGCGGTGATGCGTGTCAGCCAGGCTGTCGTGTGCCACCGATCCTTGACCGATTGCCACTGAAGTTGGACCACTGCACCGTTCGTGCCATCGAACCTTGACCGCCCAGGTCCGAGCCTCACGAGGCGGTGTCAGTCCCCTGTTGGATGATCCGGCCATGCTGATAGCGACCAACGAACTCGGCCACGTGGTGAAGCGCGCCACCAAGCCCGCCATCGGAGCGATGCTGGCCAACCTGCGGCGGGGCAACGCCCACCTGATCGTGGAGCGGGTGGACGAGGAACTGCCCGGCAGCTGGTACATCCAGGTCCTGCTGCGTGAGAACAACGCCTACCAGCTCGAATACCGGGACGGCGGGGCCGAGCAGCACTTCCAGACCATGACCGTTTCCCAGGAGAAGGTCCTCGTGGCAGTGTTCGGCTGTGCAGCCGCGAAGCCGAACTGGCAGGACGGCTTCATGTGGAACAACATCGGCGAGCAGTTCAGCTCCAGCCCCCGGGCGGCACCCGAGCCTGCTGACGGTGCGAAGCAGTCGGCGGCCCCGGGAACAGTCTGACCAGGGCGGTCAAGGTTCGATGATCGCGCCGTCGCGGACAGACTGCGGCCACGTCCCACGCGGCAGTATCACCGTCCAGGCGACGGTGTCCGGGCAATGGGTCGGTCGGCCTGACCCAGTTGCGGGCGGGCGACGACCGCGTGTCGGGCACCGTGCTGCCCCGTGACTCCTCACCGACCGCGTACGCGTCCGGCACCGGGGCGTCGTCCTGGATCTGGATGGCGGCAGCGAACCGTGGCGGGCAGCCGTCCCTTCGTGAGGGATGGCGAGTCGTCGGACACCGCTCATCGCCGGACATCACATGGGTGGCTGTCTTCGACAGCTGGCGGCGCGTGGGCCACCACCGGGTGGCGGCGGCCCACGCCGACATGCATTCTGTCCGCGCTCCCGGCCGGAAGCGTGGGTGGCTCTCCTGGCCGCCTGGGAACGTCGTGCAGCCGCGAGGGGCCGGGTCAGCTGATGGACTTGATGGCGCCCCAGCCGCCGCTGCCGACCTGGATGCTCGGGCCGTCGACCGGGCCGTGGATGGAGGTGTCGCCCTTGTAGAACTTCAGGGTGCCGTCGGCGGCGGTGGCCCACATGTCGGCGATGCCGTCTCGATTGGCGTCGGCGGCGCCGGCGATCAGCGGCCGGAAAGCGTTGGTGTACCCGCGGCCGTACTCCGTGCGGTCGCTGAATGTCTTTCCGTCGGGCTGGCCGAGGTAGTGGTAGAGGATGCCGTCCCGGGTGTCGCGGGCGAGCAGGTCGACGCGGCCGTCGTGGTCGGCGTCACCAGGGGCGGTGAGGTCCATGACGTCCCACCCGGACGTGCCGATGATGACGGGGGCGGCGACGGACGGCGCGGGCCCCGCAGCACCTGCGTAGAGGTACAGCTTGTTGGAGTGCTGAACGAGGAGGTCGGGGTGGCCGTCCTTCGTGACATCGCCGGCGCCGACGACCTGGGCGGTGGTGGGAAGCCCGCTACCGATCTTGATATGCGCGCCGAGCGTACCGTCGCCCCGGTTGGGGTAGACCCGCAGTTCCCCGCCGACGCGGGCGACGATGTCCTCCTTGGCGTCGCCGGTCCAGTCGCCACGGTGCGTCACGGAAGATCCCGACCAGCCGCCGGTGCCAATAATGCTGTGCGCACCGAGGGCGCCGGTACCCGTGCCGGGGTAGAGGCGCAGCTTGCCGGTGTCGTCGATCGCGACGAGGTCGGGCTTCTTGTCGCCGGTCATGTCGCCGGGAGCGGCGGGCGTCACGCTCTGGCCGAGCTGGATTCGCGGAGTGGTGGCGCCTTCGTAGGCGATGGCCTTGCCGTCGTTCTTGAGGATCGTTTCGAGTTGGTCGATGCTCTTCGCGGGGTAGGTCTGCTTCAGCACTGCGAGGGCCCCGGCGACGTGGGGGGCGGCCATGGAGGTGCCGTTTCTCGAACCGTAGCCGCCGCCGGGAAGCGAGGAGATGATGCTCGTGCCGGGGGCGAGGAGGTCCAGCAGCGGTCCGCGGTTGGAGAAAGCGGAGAGTTGATCGTCGTCGGTGGTCGAGCCGACCGTGATCGCGGAGGGAACGCAGCCGGGAGCGTTGACGGCAGCGGTGTGACCGCTGTTGCCGGCGGCCACGACCGTGGCAACGCCAGCGGCACGCAGGGTGTCCACGACGACCGTACGCAAGTCCTGGCCGCAGGGGGTTGTGTAGTGCCCGCCGCCCAGGCTCAGGTTGGCCGCGACGACGTTGGTCCCTGCCTTCTTCAGCGCGAGGACCTTCTCCAGACCTTTGATCTGGGAGCTGGTGTAGCTGAGCACGCAGGGGCTCATCCCCGCTCCGCAGAAGTCGTCGGAGTCGAACTTGGAGAACACCTGGACGGCGATGATGTCCGCACCGGGCGCGACACCGTGCCGCGGTGCCCCGCCAATGCCGGCTCCGTTGCCGGCGGCGATCCCGGCGACGTGGGTTCCGTGAGAGCAGTCGATGCCCGTGGTGACGCACGGGCCGCTGTCGGCGTCGGCGCTGCCGGCGCCGTCCTGCTGGTCGGAACCGTTGGGGCACAGACTCGAGACGCCCGACTCCGCGTCATTGACGGAGAAGCACGCTTCGGTCCTCACGCGGCCCGAGAGGAACGGGTGGTTGACGGCCACGCCGGTGTCGAGGATCGCGACGGCGGTGCCGGCGCCAGTCTTGCCTGCGGCGACGGCCTGGTCGGCGCCGATCTTGAGGGTGGATTCGTTCAGTGTGGGCGGGACCGGGACGTCCTCGGTGACGCTGATGACGCCCGGCCTGGTGTTCAGCTCCTGGAGGCCCGCCCTGTCCACGCGGAGGGTGACCATCGGCAGGGTGTCGTACGAGACGAGGGTCTCGCCCGCACCGGCAGCGGAAGCCAGGTCGGCCCGCTGGCCGGTGACGACGTTGACCCGGACGGTCCCGCCGTCCTGGGTGTCGTCGAACAGCGGAGGGTCGACCGGTCCGCCGCCCTCGGCGGAGGCGGTGGCGGTTCCGGACAGGGGGTTGATGCCCACCGGTATCGCGGTGATCACCATGGCCGCTGCTGCGGCGGCGACCAATCCGCCCATGCGAATTTTCACTTGCTGCTCCATGAACATAGGGCGGGTGCGAGCTCGCACCAGGAAGGAAGAATGTGGCCGGCGGCATCGGGTCATGGCCGCCGAGGGTGGCTCCGCAGCTGCCGCGGGAGTGAGCGGCGCGGCTGCACGGACCGATCCGAAGCGCCGAGGGACCTCGTCGTCATCACGGCTGTGCCAGTTCAGTCGGCCGTCGTTTGCAAGGGAAATGCCGCGGCGGCCGGGGCGCGTCCTGACTCGTCTCGTGGGACCCGACTCGGATCGCAGCGATGCCGAGGTGGCGAAGCGAGGCAGCCGAGATGGTGCACGGGCTGGTCGGAGGGGTGGGGCCGGGGCGGAGAGGTTCCGCCCCGGCCCCGTCATGCCCGGCCGCACCCGGTCCGGCTGATGTATGGCACGTTGTGGGAAAGAGTCGGCGCCCTTACGTGGCGTCAGCGCCGTTCTTCGGGTTGCCGCCCCACCTCTGGTTGCTCACGGCCTTGTAGTAGGCATACGCCCAGTTGTTGCAGCCCGGCCGCCTCAGGATGAAGTACGCCTTGCAGCTGTAGGTCTTCATCGTGGTGTGGAAAGCGTTCTCGACGTTCGACTTCTTGCTCCGGTCGAGGTAGTACGAGTAGCCCTTGTACGTGTTGCCGATGAGCCCGTAGCCGTAGTCGTGCATGTCGCACGCGGTGCGGAAGTTGAAGCCGCCCGGCCTGCTGACGTTGGGGCCGGGGGTGCTGCAACCGTCGTAGTTGATGCCCACGACCCGGTGGTTGGTCGGCGTGGTTTTGAACGTCGGCTTGTGCCAGCCGTAGTGCGCAGCCCACGCTGCACAGTTCCTCTTGAGGTACCACAGCCAGTCCGTCGCGGCTGAGCAGTGGCGCGGGTAGGCCTGCGGGTCGGTGATCTCTCCGTTGATGAAGTCCGTCGGCAGCGGGCCGGCGGCGGGGTCGGTGATCCCACCCGCTCCTTCGAGCGGTGCGTCCGCAGCCGGTCGCGCGGGACCGACGGGCTCGACGTTCGGCGAGGCCGAGCCGGCCGGGAACGTCAGCTCCCAGTTGCCGTTGGCCGGCGAAGCCACGGCGGAGACCCGCCCGGTGGTGTCATAGGAATACGAGGAAGCCGCGTCGATTCCCTCGGCCGGGTTGGCCACCGAACGGAGTCGACCGGTGGCGTCGTAGGAGTACCGAGCGAGGGTCTGCACCGTGGCGCCGTCGGTGAGGGTGATCTCCCTGGCTCGGCCCGTGAACTCCCCGGGGGTCGTGCCGGTGGCCGTGGTGGCGGTCGAGTACTTGACCGTCAGGAGCCGGGAGGTGGTTTCCCCGATCTCGGCGTCCTTGACGGTGGCGACCCGACCCGCGGTGTCGTACGTGACCGTGGACAGGGCGCTGTTGGCGGCAGTACCAACCCCGGTGACGCGCCAGCTGTTGGCTCCAGTCCCCACCTGCTTCCAGGTGTAGGTCGGTGCCAGCTGAGCGAAATTGCTGGGCGCGGTCGCATCGGCGTCAGCGGACAGGTCCTCGTCCGGTAGCGAGGTGGCCGCGTTGGCGCTCTCGACGGCGGTGGACACCATCGTGCCCGTCGCCTCGTTGAACCGGGTGGTCTCGGTGAGGGTGTCCCCCTCGGGGGTCGCGTACTTCCTGACGCCGCCCCCATCCGGGAAGTCGAGGCTGCTCTTCAGAGCGTAGGTGGCCGCGGCGTTCATGGTGAGGTCGGTGACGACGGCCGTATTGCCGCTCTGCTCCAGCTTGCGGTTGAGCTGGCCACCCACGAACTCAGCTTCCCAGCCCGGGCCGAAGATCCCCATGTCCGCACGGGCCACCGGTGCGGACTCTGGCCTGGACACGCCGTCCGGCTGAACGGTGACGGTGTGACTGCGGCTCATCAGGCCCACTGCCACATCGGTTTCGTAGATCTCGAACGACTTGTCCGCCGTCGAGTACACACCGGGACCGACCTGCTGGACTTGGCCGTCGGCCAGCGGTGGATCGACGACTGCGGACCCCGCCGCGGGTGATGCTGCCGCAGGTGTCGCCCCGGCCATCTGCTGCGGGAGCAGCAGAGACAAAGACACCATGGCAAACACTGGAAGCGCACTTCTTCTGCGCACGAGTCCCCCCTCGTGAGAAAAGTGTGAATGATCCGAACGGATCGGTGCGGACAGAACTGCGAATGGACTGTCCATCTAACGGGCCGGCCGACGGCCCGAATTGCCCCTCCTGCGGAGGGGACGCCTGGAATCTATCCGCGGGCAGCAGCGGGAGGTAGCGCCGTCGTGCACAGCGTGGGGCGGCCTGAGGTTTCACACGGCACAGTGATCGTCTCGGTGCATCGCCGCGTCTTGCCGGGCCTGGCTGTCGGCCGGGGGGTGCAGGCACCGCACCTATCGCTGTCTTCCCGCCTGGGAAGAAGGCGTTCCGCTATGCACGAGATCTTTCCTGATCAGCAGCTCCGCCGAGGCGGGCTGGTGGTTTGCCTGACCACCCGCCGCCGCCATGCGCGGCCGCGCCCCGGCCCCAGGTCAAGTCCCGACGAGGGGCCGCTGCACGTGCAGGTGGTCAGGATGCGCACCCGCCCTGGTGAGACCCGTGGGGGAACGGATGGATTCCCAGGGGCGGTGTGCGTCCCACCCTCACAACGACTGCGCATCTCGCCGGTTGCGCCGATTCGGACCGAGGCGAAACTCGTGTTTCTCTTCCCCGAAGGAGTGACTGCGCAGGGGTTGGAAAGGGATCGCGGCCAGCTTGCGACGCAGGCGGGGTATGCGGGGATCCATCGTGCTCTTCTCTCGTCCCTGTCACCCTACGGGACCACGAAACCCGCGCCGGCCAGCGCCTCCTCATCCCCCATGACCGCGGCGACCTTGACCTCGCCCGTGACGTAGCCGGACTGGTCGACACGGACAACCGCCTCTTTCGCCTTCGACCGGCCAAGGAGAGCAGCCGGATCCCAGCCAGCAACAGCGGCCATGGCGACGACGGCGGCCGAGACGGCCACCACACGAACACGACGAATAGGCACGCCCCCCACCTTGGCAGCCGCCACCCGAAGGGCCGCTCAACGCCGCCCGGCCCGGCACAGAGGTTGACAACCACGGGGGGTGTGCCGCGCGAACGGGCCGGCCACCTTGAGAAGTGCACGACGAGCGGCTAGGGGGTGTCCGGCGGATCATAAGGCCGTAGGGTCTGACCGTGATTAACCTCCATGTCCGAGGCGAGAGCGGCACGATCGAGGCCCGCGCGAAGCACGGTGTGCTCTGGGGTCCTGAGCTGGCTGGTCTTGATCAGGCCGTGTTCCCGATGCTGGGACACCTGCTGCCGTATGGGGACACCGTTTTCAACCACCGGCAGGTGTCGACCCTGTTGGAGGAGGTACCGCGGCTGCCTGCAGGCGTGCTGACTGATGAGTTCGCGCGCGAGCTGATCGAGCTGGGTCAGGTGGTTCTCGCCGGACAGGGCCTGTACCTGTGGTTCCTCGGGGACTGAGGCTGCAGGCCGGCTCAGCCTCGGAGCCATAACCGGACAGCCGCGGTGGTGACGGTGCTGTGGAAGACGTAGGCCCTCTTGTCATAGCGGGTGGCGACAGCCCGGGAGTTCTTGAGCCGGTTGATCGTCCGCTCGACTTCGTTGCGGCGCTTGTAGATCTCGCTGTCGAAGCCGGTGGGCCGGCCGCCCTCACTGCCGCGGCGTTTGCGGTTGACGGTGGCTGATGATGCGGTTGGCCGCGGACTTCGAGACGCCGAACAGTGGTGCGAGCGCCGTAACGTCAAGTTGGTGCGCCAGTACGCCGTGGCTAACAGCACCCGGTCCTCCGGCGGCATGCCCCACGGCCGGCCTGCGGACCGCGTCAGCTCCTTCACGCCGCAGCTGTGTCACCAACGTGCTGAAACAGCGAGGGCTCAGCCCGGTGAACGGGGCTATCCAGGACGGCTCCGACGCCGTGATCACACCAGACACCGCAGGGTCTTTTCACGGGCCGCGGTGCCGGTCAGCGGGCAGTCAGGAAGGACGTCGCTGCGGTTCCACAGCCCTGAGCAGGCACTCGCGGTCATCCGCGCTGATCAGTCCGTCCGGAAGGGTTCCGTCCTCCAGCAACGCGCGCAGGGCGGACGCGTGTGCGGCGAAGGCGGCCCTGCACCACTCGCGTTCCGGGTGATCGGAGTCCTTGCCGAACAGCAGCACCTGGCGTTCATCGTCGGCGTCGACGGACGAAGACAGTTCCGCGGCGACGACCAGGAAGTCGACCAATCCGGACCGCACCGCGATGTCAGGGACGGCTGCCAGGCGGATCAGGAAGGGCAGGACGGCCGGCATCACGGCGCTCACGTGGAAAACACTGTTCATCAGGACGTTCTCCAGCACGGTCAGAGCCGCAGGGCCGGCCACCTCATCCAAGAGACCGCGGAGCAGGACCGGGACCCCGGCAGGGCACCCGGGAATCTGCGACCAGTCGACGTCGGCGCAGCCCAGCAGCGCGGGGTGGTCGCATGCAGCTTGCTCCATCAGCGGATATTCGCGGAGGAACCGAGCAACGGCAGCCTCTCTGACCGCCGCGTCCATCTCACACATCTCTCTGCCCCTGCTCCCACGCCCCGCCCCGAACGACGTCCGCAGGACGGAACTCTTCCCGGGGCGGGCGTCGAACGCAAGCGTCAGGTCAGTAGCCGCCACCTCCCGCTCTGGGGTAGCGGCGCTCCAGCCCGGCACTGGATTCCGGGACAGCCCTTAGTCGAGCGACGTGTCCTGAGCTTGCCGTTTAACCTGTGGTCCGTGGGGCTTGCTCTCTGGCAGGGATGAAGATCGCTACGTAGTTACGTCGCTTGTGAACCAGGACGTCGTCGGGGAGCACTCGCAGGGCGTCGTGCGGGGCGACCTGTCAGGTGTCGCGGTCCCCACCCTGGTCGGGATCGGCACACTCGAAGTCGCCGACTTCCAGGACATCGGCCGCCGCTACGCCTCCGAGATCCCCGGCGCCGTCATGATCGAGTTCCCACCGCCGCCCGCCTCATCGCGATGGACGCGTAGAGGTACAGCTTGTTGGAGTGCTGGACGAGGAGGTCGGGGTGGCCGTCCTTCGTGACATCGCCGGCGCCGACGACCCGGTAGACCCGCAGTTCCCCGCCGACGCGGGGGACAATGTCCTTCTTAGCGTCGCCGGTCCGGTCGCTGCGGTGCGCCACGGAAGATACCGACCGGCCGCCGTTGCCCATGCTGTGCGTACCGAGGGCGCCGGTACCCGTGGCGTGTAGAGGCGCAGCTTGCCGGTGGCGTCGATCGCGACGAGGTCGTGATTCTAGTCGCCGGTCATGTCGCCCGGAGCGGCGGGCGTCACGCTCTGGCCGAGCTGGATCCACGGAGCGGTGGCACCTTCGTAGGCGATGACCTTGCCGCCCTGGCCGTTCCCCCTATGTGCGGTGGCAGGAGACCGGCGGGCGCGTAGCGCGCGGCGTTGCTGCTCCTCGCGGGCAATCTCCCGGGCGAGGATGTCGCGGTCGATGTACGGGTCTACGGCGGCGAGGACCAGGCGCTGGAGTTCGTCCGGCTCCAGCGCCTCCACCTCCCACTGGACCGGCCGCTCGATGTCGAAGCCGTAGCGGCGGGCGAAGGTCGGCCACCTCGGGGCGATGTCGGTACGATCCGTGGATGTCTTCGGAAGATCTTGGGGCCGTGTGGGTCCTTCAGGGGTTCAGTAAGGTCGACGATTTCCTGCGCACCGAGTTTCCCATCGGCCGCGAACAGATCATGCAACTCCGTGAGGTGATCACTCCCGACGCGGACGACCCTTGGATGTTCGATGGGTACGACGTGCCCATCGAGCTGTGGCCGGCCGTGGACGCGATCCTGCAGTGTGGGCCACCCGATCCCGGGCTCGACTACCAGACAGGGTGCTACGCGGCAGACTAGGCCCGCCGGCCGACGCCGTCCTGGCGGCAACGTCGGTGCACGTTGCCCGTCACCGGCGCCGCTCTCAGCCCTGAGCAACGCTGTGTTTCTAGCTCGTGTCCTATGCGGTGAGGCGGAGGAATTGCTTGTAGCAGCAGATGGCTGCGGCGAGGCCGAGAAAGGCGAGGTAGTTGCGGGGGTGGCGTTCGTAGCGGTGGTTGAGTCTGCGGTAGCCGGTGAGCCAGACATGGCCCGCTCGATCACCCTCCGGCGGCGGCCGAGTCGTTCTGATGACTCGATGCCCTTGCGGGCGATGCGGACGCCGATGCATTTCCAGCCGCTGTGAGGACTCGACCCCTTTGCGGGCATCGACCGGGGAGACGACTATTTAGTGCACTGGGGCCTGACCCACTTCCTCCTCGACGGCCACCACAAACTGGAAGCCGCGGCAACCGCCGGCCGGCCGGTGCGGCTCCTCTCGCTGCTGACCGTGGGCGAGAGTCTGGCCGGAGCCGAAGACACCGCCCGGCTGCCTGCCTTGCGCGCGCAACCCCGCTCGGCCCGAGCGACCAAATAGGAGGCCCGAAGCTCCTGCCTGTGCCAAGCCGGGACCCTCCCCTCCCACGCTCGCGCAGACGGCACGATCGACTCGAGATCGGCCGGTAGACGCCGTTGCGCGGCTCCGGCCAGCTACAACGCTCAGTGGTCAACTACAGCTGGCCAATATGAGTGTTCCAGAGGGCCCCTGCCGCCCTCGGGACACCCGTGACCTGCACGTACGGATGGTCGGAAAACTGCCCCGAAGCGTGTACCCCCAAGGTCCTCACGCCGAGGCGCCTCCGAGCCGCGTCTAGGCTCCCGCGCATGGACATGGGCGAGCGGTGGGCGGAATACGACGGGCTGCGGGGACGGGTCCCCTCGTGGCATCCGGTCGGGGTGGTGGTCCGGGCCGATGGGCCGGTCGTACGCCGGCACTACGGGACGCACGGCACGGTCGAGCACGCCCCCCTCAAGCCCGGGACTGACATCGCCGGGCTGGTGCGCCACCAGCAGGAAGGTTTCGCAGAGCGTGGCGAGCCCGTGGAGTGGAAGGTGTACGGGCACGATGCGCCGGACCTGAGCCGAGCGCTGACCGCGGCTGGGTTCACCCCGGGCTGGGAGCGTTCCGTGCTGATTGCCGAGGAGCTGCCGGGCGAGCCCGATGTCTTGGTGGAGCCCCGGAACGACATCCGCAGCCTGTACGCGGTACGGGAGCAAGCCGAACGCGCCTGGGGGATCGCCGTCGGTTCCCCCGGCCCGCACGCGGTGCCCTACGCGGAGATGATCGCCGACGGCGCCTCGGAGGACGGCGACGTCTACATCGACGTCCTGTTGCAGCACCGCGAGGTCACCGCCGTGGGCTGGGTCTACGCCGACCTGACCCGTCCCTTCAAAGTCGTCGGTGGGCTGAGCAGCGACGACGCAGAATTCGTCCAAGGCTGCACCGCCCACTGGCGCACGCAGAGCTCGCGTCCCCTCCTCGCCGAGGCCGGAGGCCTCCTGCGCGAGCGGCTTCTGAAGGCCGGCTTCATGGAGGCGGCCACCGTCCGCTCCTACCACTGGCGCCCGACCGGCACCCCCGAGATCACCCGACCCGCGCAGTTCCTCGACTGGCTCCACGACGACGGTCCACTGAGGGACCGCTTCCAAACTGAATTCGACTTCAAGCCGAGCACCACGTCCCTGCCCGCGATCAGCGCTCCCGTTCCCTCCGCCGTCTGGCATCTGCACGCCCACCACCGGCCCGTCCCTGACCTCCCCGAACAGATCGACGCGATCGTCCAGCGCGGACTACTCACAGCCACCAAGCCCGGCGAGTTCGTCTACTGGCTCGACTGGCAGCACGACGGCTATCGCTACGACCCCCGCCGCACCGACCTCCCCGGACGGCCGCCCCGACCCGGCAAAGGCACCTACCCCAATGGCGACTACTACCTCCACCTCACCGACGACCTCCGCCTGGGCACCTTCGGCCACCCCTGGGAACAGACACTGACCGTCTGGGGGCCCCCGCTGCTCGCCGCCGTCGAGGCAGAACTGACCGAGCTGCTCGGAGAGCCGGTCAGACGCCGCGGCTGACGGGTGGCCGGGTCCCCGTCCTCGTCTTCAGGTCGGGACCCGAACGCCACACAGGTCGGCGCGGTTCCGCAGCCCGCCGAGCCGCACAACGGGCGTGAAAGCTGAGTGGTGTAGTTGGCGGGAGGGGCCAACTAAGGCCGGCAGTCACAGGTGCGTCGTGACGGAGCACTGCACCTGTCCGATGAACACTGGACTTGTCGGGCTGTGATTCCTGGGCTGTGGCGCACAGCACTCCCGACCTGCTCACGTTTGCGCTGTGCGCCCGCGCGTGGCGTTGATCAACACGCAGCCTCTGCGCGGCTGGAGCGCGAGCATCGGCCCGAGACGGTCGATCTTTTTTCGCTGGACGCCGGGTGATCACTGCGGCATGCTGCGGGACATGATCTACGGAATCGAGTCGCGCCCCGTCCGGTGAGCGCCCGCGAAGAGCGCCCGGCGCTCCGCTCCCAGACGACCTCCCTCCACGACTACGCCCTGTTCCGCCGCGGCATCGAGCCGGACGGACGGGCTCCCGCCTACGGCTACCCGGTGCCCGGTGACCGGCTGCGCTCCGCGCTGCGCTTCAGGGAAGCCACCCGGCTCCTGGCCCAGTTGCTCGGTCCCGCTGTGGACGACCCCGATCCGGTCGGGGCAGCGGCAACGCTGGACCGGCGGTTGCCCCAGCTGGGTGTGCGCCCGGACCTCGTGCACCATCCCCTCGCGCGGCTGCCCCTGACGAACGAGTCCGCAGCCCTCGCACTGGGCCGTCAGCTGGTCCGTACGGCATCCGATCCGACGGCGCTGGGGGCGGGAATCCACCTGGTCGGCCGCCTCGGCGGGTCGGAGGACGTGCCCCAGCTCACGACACTGGCCCTGCTGCAGGGCTTCCTCCGGCCCGTCGTCACGGCCCTCTCGGCACTACGGTGCGACACCGAGGTGCTGATCCGGCTCATGGACCTGCTGGATCCGCAGGATCACGGCGTGGTGATCGACGCGCTCGCCTCACGTGAGGACCCGGCAGCCCGTCGGTGGCTGCTGAACCTGCCCGTGGGGCCCGGCACGACCAGCTCCCGGGCCCACCACATCGCCCTCGCGGTCCGCCTCGCCGACCTGCTGCAGGACGAGTCCGTCGATGCGTCCGTCCTGGCGCAGGGCGGCCGGCTGCTGACCCGGATGGCGCTGGCGACCGGCTCCCCCGCCGAGGTCCTCGGCTACGGGCCGGCCATCGCCGTTTACGAGGCGCTGGTGCGACGGGCCGACCGGCTCCCGCCCACCCTCGACCACCACGCGATCCTGCTCTCGCTCGCCCTGGACCTGTCCAGCGGTGCGTCCGTACTCCTGGACTGGCCTCCGGGGCTGCGAGAGGAACTGCTGGAGCGGCTGGAGCGCCTGCTGGGCACCCCGGCCTGGGCGGCGGTGCCGGACGGCGGCCATCGACACCGCGACCGGTACCGGGCCGACTGGATCCGGCGCATGCGACGGGAGCCCCTCGACCGCACCACGCCGAACGGCCTGCGGATCCACGTGGTCGAACACGATCCGGAGATCGGTGGCCACGTGGAGGCCCGGATCCTGCTGGACGGCCGCCCGCTGGTGCCCCGTCTGTTCCCCGCGGGCCACAGCCCGTCGCCGGAGCACGTCCTCGGCCAGGACCTGCTGCGGGCGACGCCCGAGGAACGCACCGTCACGCTGTCGACGGCGGAGTGCGATGAAGGGTGCTGCGGAACGCTGTCCGTAACCGTGCGGCGGGACGGGGCCCACGTCGTGTGGCACGGGCCCCGTCAGAACGGCATCGGACCACAGCTGCCCGAGCACCGGTTCGACGCCGCGGCCTACCACGCCGAGGTCGACCGTGCCCGGGCGGACGACACCTGGTGCCGGCCCGCGCGCAGCACCGCCCGCCTCATCCAGGCCGGGCTCGGGGAGCGGCCCGGCCTGCTGGCCCGCTGGGGCATCCTGCAGAGTTGGTGCCGCCCGGCCGGCCCGTACGAGGACACCGTCGAAGTGGACTTCTGGTACGGGCCCGGCGCCGGCCGCGACCCGGTCGGCGACGAAGCCGGCCAGTGGGTCCGCCTCACCTGGCGCCTGCCCGACGACGGGCGCCGGCCGGGCGTGCGGGCCGCTGCCGCGCTTGAACGCATCGCCGCCACCGACCCGAAGACGTACTCCCGGGTCACCGGCGGGAATGCGGAGTAGCCCGAGCCGTCGAATACGCCACCAGGCCGACGGGTGAGGGGGCCGGGCCGGCTGCGGCCCGGGCTCCCCGGGGCGTGTCCGGGCACCCGCTGCGGATGCGGGCCGTGCGGGGTCTCGCGGCTGGGACCCGAGCACGGCGGCGCGCCGGCTCCCCGCCCACTCCGGAAAGAAGGGGTTCCGTCTTCCGTGCGGTCGACGGCATGATCGGGCCTCGTCGGCGGCCGCGAGGCAGGCCGGGGAGCGGCGCCGGCCCGTTCCTGACCCCGCCTGCCCCGGTTCCCACGGGCCCGCAGGACCACGGCGGGCCCGTGGGAACCCCATCCGGGCACCAGCCGTGGCAGGATGGCCTTATGTTGATCCGAAAGGGCGATGCCGCGTAGGCGTCCCAAGGCCGTCCGTGCAGAGCGGTTTCGGCCACGATGGCAGTACCCGGTCCTGCAAGTCCGCGGTGTCAGTGCGCGGACTCGTGCAGCGATCCGCCGGGTCGAAGACCAAGATATGTGGCCCAACGCGGTCGCGGATGCGCTCTCACGCTTCGAGTGGGCCTTCAAGCAACCTGGCCGCTACCTGAACGCCTCCGAGGCATGCTCGCCTGGGATAGAGGTGGAAGACGCCCGTGACGATCTGGAGCGGGCGATGCTGCACCTTCCTCCCGGAGCCCAACGGGACTTGGGTCGACTGATCACGCGCATCGATGAGGAATTCGAGCGCCGCACCTTGCCGGAGCCCAACTACACCGAGTGGGCAATGCACGGCTGGTGGTGGACCAGGATGCGTGAACGCTGACAGACCCGGCCTCGCGCTCCTTCCATCGCATTCGAACACCCCCGTTACCCTCCGGAGGCCGAGCCGGGCTGATCCCAGTCTGCCCACGGCGCCCGCGACGTGCCGCTCACAGTGCTGGCCACCGCGCTGGGTACGAGCGAGGCCGCGGCCCGCACCTACCTCAACGACTACCTCCACCCCTGACCGCAGGCGCCACAGACAAAGGGGCCGCCCCCCTCGTCGGCGGTGGCGGCCCCGTCAAACCGTCCGCGTTGGCGCTACGGGGCGGGGGTGAACTCCACGTCCGTGCCGCTACAGCCGGCAGCGATGTCCAGCAGCCGCTCCCGCTCCGCCTCGTCGGCCGCGAGACCCCAGCGGAGCTTGGTCGCGGTCCATTCGGCGCCGTACCGGCACAGCGCGTCCGGCGCCGGCGGGAGCCACTGCGCCGGGTCCTGGTCGGCCTTGCTCCGGTTCGAGCGGGCCGTCACCGCCACCAGCGAGGCCAGCTGACCTTGATCGTTCGCGTATGCCTCCCGCCGCGCCGCCGTCCACGCCGCCGCCCCAGAGTCCCAGGCCTCGACGAGCGGCACCATGTGGTCGATGTCCAGCGCACCGGCCGGCGTGACCTCCCGCTCGTCGTAGTACAACCACCACACCCCGCCGGTCAGGGTGCAGCCCGGCCCGATCTCCGGATACACGACCGCCTCGGCCAGCAGTACCTCGGCGCGGGTGTTGCAGCCGTCGGCCGGGACGTCGCCGGCGTTCCAGTGCCGGAGTCGGCCGAGGCCCGGTCCTTCCTAAACGGGCATGACCCCGAGGTGGCCAGCCAGCGGAGGTCGTCTCACTCTGGCGCCGGGGCGGGGTCGCGCCGCCGAAGGTCTTGCACCGCCAAGGCCACGCCTCGGCCATCGGCAAGCATCGCCCAGAGCCCCATCGGGACAACAAGCCACCGCCAGTCACTGTGAAAGTGCGTGATCACGGCGACTACGAATACCAGCTGGGCCGCACCGAGCAGGAGGTTGCCCAGCAGGCGCAGCATCGGGTGCGGTCTCCTGCGGAACACCTCTTCGAACCAGGTCTTCTCCACGTTCCCACCCCTCATTCAGACCGGGGCCCCCGGACGTCGACGGGGGAACTGTAGCGGCGTACTCGAACAGGCACTGAGCTTGCGATTTAACCTTCGGAGTCTGGCGGGGAAGGTTCGGTTCCGGCGGGGAGGGTGACCTGAGCGGTCCATGACCAGGGCTCCCGAGGGGGATCCCAGCTCACCTCGACGTCGGTGTCGTGGAAGTCTCGCGCGAGTTCCGTCACCATCCGGGCCGCCGCGGCTCGCGCGTCTTGTGGATCGGTGTTGATTGGCACGTCCAGACGCCCGCAGAGCATGCCGCCTTCCATGGTGAGGACGCTGTGGCGCCAGCCCTCTGGCGTCGCCAACAGCACGATCCCCTTCGGGATGCCCCAGTCGGGCCGCTTCTTCTTCTCCTTCTTCCGTCTCACCATGCGGCTATCCAACATCGTCGGTGTCGTGGCGATGAGGCTGGGGTGGCAGCTCAGCTTGCCGGTTGCCCAGTTCTTCGGGGTTTGGTGCCGACCTTGTGGTGGGCCGGTCGGGTGTAGGACTCGCCGGTGGCGAGGACGCGTCCGACGTCGTAGCGGGTGGCGGGCCGCTTGTTCTTCGAGCCGGGCGGGCGGCCGGGGCGGGGTCGGCTGGGTTTCGGTGCACGGGCTGGCGTGCCGGTCTGCGCGTGCAGGTTCCTGAACCCGCGGCGTACTCGGGCGGGGGTGAGTCTGTACGGTTCCGCTGGTCGCTCCCACGGCCGGGGAGGTCGCGCGCGAGCGGGCGGGCAAGACGAAGTTGGGCGTGTGCCGCGAGGACGATCCAGGTCCAGCGGTCGGCCGCGGCGGAGTCCCGGAGCTTGGGACGGGTCCAGCCGAGCGTCTGCTTGAGCAGGCGGAACGTGTGCTCCACGTCGAACCTTCGCAGGAACGCCCGCCAGCACCGATCCACGTCCTCGGGGCCCGCACCGGTGCCCGACCACCAGAGCCAGGCGGGCTTGTTCACCCCGCCGCTTGGCAGCTTCGCGACCGTCAACCGAATCCCGGTGCCCTCGGTGATCGGCAAGGGGCCCTCATGGTCAATTTCGGCCAGCTGCGCGCCGGGCGCGGGGTACTGCGTGATGGGGCGTGGTCGGGCTGCGCGCTCATCGGCGGGTGCTCACCGAGCGGCAGGGGGGAACGACTCCCGCAGTGGCTCGAAGCCGGTCCGCCGGGACGTTCTTCCCAGTCCCCCCACACTCTCGCGGCCGGCATCGACCGAGACCGCGACGCCGTCATCGCCGGCCTGACCCTGCCCTGGAGCTCCGGCGTTGTCGAAGGGCACGTCAACAGGATCAAGATGCTCAAGCGCCAGATGTTCGGACGCGCCGGCTTCACACTGCTCCGCAAGCGGGTCCTCCTCGCCCCGTGACCGACGTCAGTGGCTCCTGGAACCATGCCTTCGTCCGAGACAGCCGTATCAGGAGCCATGCATGGGAACGTGGGGAACCGGCCCGTTCGACAGCGACCTCGCCGCAGACTTCGTCGATCAACTTGAGGGGCTCGCCCACCAGCAGGTCATCGCCCTGCTGGAGAGGGCATTCCAGCGAGTCACCGACTCAGAGGAACGCGTCGACGGCGGAGACGGGGCCGAAGCCGTCGCCGCCGGCGCCCTCGTCGCCAGCACCCTCCCAGACAGCCCCATCGTGATCGACCCCGATGACGGCCCCAGGGAACCGCTGCCCAAACTGCCAGCCTCCCTTCGCGCGTCGGCGAAACTGGCACTGGACCGGGTTCTCCAGGACGGATCAGAACTGACAACCGGCTGGGTGGACAGCGCTGACGCCAACCAGTGGCGCCAGGAAGTGCGACAGATCCTCCAAGCACTCGAAACACCCACTGATCACTAATCGCGACCGCTTCACGAAAGTCGTGCCAGAACCCGTCAACCGACAGCGTTGTTCGTGGGTTCCGGCGGCGGTCAGTGATCACCGGCACTCTGGATGTTCACGGCACATAACGGCAGCACCTTGGTCGTCCCGCCCGTCGACCGGCTTCGGAGACCCGTCGTGATCGTTCGGCGGAAAAGGAGCCGTGCTGTCTGCGACAGAGGTGACACCATGCGGTGTCATGGCAGATGACAGCACCAGTACGTTTCAGGCGGGCCAGACGGGCCTCATCGTCCGGATCCCGGAGGCGGAGCCGTCCGTCCGCGGGTGGCGTGAACAGCTCGACCCCTCAGCCCAGGCCGGGGTTCCAGCCCACGTCACCGTGCTCTTCCCGTTCCTCGATGAGAGCCGAATAGATGCGCTCGTCTACTCCGCTCTCGCGGACGTGCTGGCCAGCCACCCGGCCTTTGATCTGCGGTTCGAGAGGTGTGGGCGTCTCCCGGAAGTGCTGTATCTCGTCCCCGAGCCTGATACGCAGTTGCGGCAGCTCACGGAGGCGATCGCTGATCGTTGGCCTGAGGCTCCGCCGTATGGCGGCCGGTTTGCCGAGATCGTGCCGCACCTGACCATCGCTCAAGGTCAGGAAGACGCCGTTCTGGAGGAGATCGAGGCCGACCTCGCCGACAAGCTCCCGTTCACGTCTCATGTCGCGTCGGTTGAACTGATGGTGCACGACGGTGTGAAATGGCAGGAACGGGCGTCGTTCGCACTCGGAGAATGAAGCAGGTCGTGGCGACGCGTGCCGTGCTGACCGTGAGCCGGTCGAGGACGGCGTCCACCCGCTCGGTCCGGACCAGGGTGCGCCGAGCGACCTCCCCGTCCTGCCTCTCCTCGATGGTGAGTGACCCGATGCGGCGCAGGAAGAGCAGCACCGGCGGGTCGGCGGACAGCGCGGTCAACTGCTCGGCCGCCTCGGCCCGGGCCTCCTCGCTCTTGAGCGGCAGGCGCAGCACGGTCACGTATCCGTCGGCCGCGAAGCCGTTCACGGCGTCGGGGACGCCGTCGAGGGGGACAGGCAGACAGAGGTGGAAGACGTCGGCGGCCACCTCCGCTGCGAGGGTCACGTCGCCGCCCAGGAGATCCTTGAGCGAGGTCTCGTCGGCGAAGGTGAAGCGATAGCCGTCGAAGACCCGGCTTCCCGCCCCGGCGACCGAGTAGACCTGGGGTGCTCCGGTCAGCTGGAGAACGCTCTTGAAGCCGATCCCCTTGTTGCCGATGCCTTCCTCCGGTCGCTTGTCCGACTGTGCGATGTAGGTCATCGCGTCGAAGTTGCTGCCGCTGACGGGCCGTCCGGTGTTCGCCACGTACACCGCACCGTGCGGGCCCTCGTCGTGGTCGAGCCTGATCAGGACCCTGCCGCCGGGGTCATCGGCGTCATGCGCGTCGTGGGCGTTCTGAAGGAGCTCCACCAAGGCGCGATGCTCGTAGTCTCGGACGGCTTGTTCGATGAGGTTCTTGAGGCTCCGGAACAGGTTCCAGCGGTCCTTGGACTCCTGATACGAAGCAATGCGGTCGAGCGTCTTCGCACGCATTTCGGCACTGCGGTCCGGCAAGGGTGTGTCCCCCTTCAGACGCATTCGAGCGCACTGAACAGTACGGCGGTAGCGACGGCGGGGGCCACATGATGCCGGGTGTGAAGCCAGGGCGGCGCCTGCAAGATGTCCTCGGTGCGGGCTGCAGCGCGCCCCGCGGGAAGCGTCTGGTCACTGCTTGATCGTCGACACGGCTGGCTCCACACCAAGCACGGCCGACGTTGACGGCCCCCGCGCGGTGGGATCAGCCCCGCGCGATGAACCGGGCTAGGTCCGTGTCACTCCCCCGCGGCAACTCCTTCACCGCCGCCCCGGGCAGCCCCGCGACGATGGTGCGCAGCCGCGCTTCGAGCTCCGGGAGCGCCGCCCAGGCCCCTTCGGGGGCCGTGACGGTTGCGAGCAGCAGGTCTCCCTCGTAGAAGTAGGCGTCCAGCAGCGGTTCCTCGGCCAGCAGGCGCACCGCGAGGGGAAGGACGAACGGGAGCGCCACCTGCTGCGCGAGGAGGGTGCGCAGGTCGGCGGGTCGCAGTTCGCCGAGCGGGACCCGGCGCAGACCGTGCACCGTGCGGACCAGCCGTGTCGCGTTGGCGGGCACGGCCTCCCAGCGCGGCGGGTCGAGGTCGTCGAGCGTACGGTCGAGGTGCAACAGAGGGTCCATGGGTGCCATTCTCGGCCCGGTTTAAGTGGAGGTGACGTGCGGCGTCCGCCCGAACACCGGCCCCCCGTGGAGTTCGGGCATGGCCCTGCGACATGATGATCATGTCAGCGCACTGCGAGCGGTCGCAGACTCCGGCGGCGCGAGCCGGTCGGCGTTCGTTCGACCGCGCGGCCGTCGCCGAGCGTCGATACGGAGGGTCGTCATGTCTTGTCGCGATCGCGCGCGCGGGGCTTCTCGGGGCCTGGCAAGCTGGTCGGATGGCCAAAGTCTGCTGGAGCGCGGAGCGTTCCACGAACGTCGAGTACGCCTCGTTTCGTGTGGGTGCGTTCTCGCTGCTGGACGACACCGTGATGGAGCAGCTTCCCCCGGCTGCCGGGGGTTTGGCGGTCGGCGAGTACGCGGTCGGGATCGGCAGCTTGGTGCACACGCACTTCGATGTGGATGTCCTGGTGGAGGTCTGGGACGAGGCGCCGCCCGTCTTGGCCGGGCAGGAGCCGCTGGGTGAGGCGTCGATCGCGGTGCGCAGCGGTATCTTCGCCGTGTACGACTTCTGGGGTGCGCCGCGGGGCGAGCCGATCCCTCTCGGCGGGCCGGCCCGGTACGCGCTGCGGGTGTACCGGTTCCCGATGAAACGGCCGGGAGCCGTGGGCGGGGCGGAGGGGCTGGAGACGTACGCGGTTCATGTGTGGCAGGCCGCTGGCGAGGCCGGGGGCCCGCCTGTGCTGCTGGAGTAGAGGTCGGTCGCTTTCGCTTCGCGGCCTGGACCCGCTCGTCGCGGTGGAAGTCCTTGTGGAGGGCCGGACTGCGAGGTTGTGGTTCTTGGCGATGTAGCGGACGGAGTAGTTGCCGTCACCGGCGCCGCCGCCCTCGCAGGCTGTCAGCGGAATCTGGGCGCTCGCAGCGGTACCAGGCGCGGAGGCTCGCCTTGACGGATTCCGCCTACGGTGGCCTCAGCGCCCTCTTGGATGGAGCCGCGAAGGAGGTCATTCTATGGATTCTGTGGAAGGCTGGGAGCGTACGTTGTGGCAGCGTTGATGTGCTCGGCAGCTTCGAAGGAGCGAGCTGCCGGTAGTTGTCGGCAAGGTTGAGTTGGGTAGAAGCCGACGATGTGGAGACTGGCGCGTGCGCCTGGACGCGCTTCCTCCGGGGCCGCGCCCTGCGACCAGACGTACGGCCCATGGCAGCGTTGGATGGTCGCCCGGTAGATCAAACCTTTCGTTTTGCTTGGGGGTGTGAGACCGCCGATCCGTCTCCCGGACCTGATCACGCTCCAAGGGACGTGGCAGCAGGCCTACGCCGAACTCGCTCAGGGCCCCGCTGGCCGGTACGGCCGCGCTGTGGCAGCGGCTGATCACTCGGCCTCCGTCCAGGCCGAGGTGTCCGTGTCAGCAGAGCGGGCTACTTCGTCACGCCGGACTGAGGCGGCGGAATTTGTGGGAGGCGAGGGGGAACGATGAGGAGAGGATGTTGGACTTCAACTCTCCGGTGAGTGCGGACGCAAGGAATTGCGTGCACGACACGGAGTAGTGTTCCCAACGGGGGCCCCTCGCCTCGTTCACCATGACAGTCCATTCGTTCGGCTCAACGCCCGGAAGAACGAGCCAGTAGAGGCATTCTCCGTTGTCTGTGGTCGCCCATGGGACAACTACGGATCCTTCGGTCTCCAGTTCTGCCGGCCTCTTTTCGAACGTCCAGAGATCTTGCAGGTCTCGGAACTGGTACTCGGCCCACTTGAGGAGGTCGTAGTGCCTGTTGGGGCAGCCGGGCTCCAGGATATAGAGGTAGTCGTCCCAGTTGCTTCCTCCGTAGACGCTGATGAGCTCCTTGTAGTCGTTGGGGAGCTCTACCGCGAGGGTGCGTTCGACTTCGCTCCACGCCTTGTCGCGGGGCTGGCTCGGCGCAGGGGCGATTTCGAGCAGACGTGCGAGGGCGTTGCTCACGGGGAGGTCCTGTTCCTAAGGGTTGGCAAGTCCGGACGGACGGGATGGCAGTGGCCGGAAGGTGTTTTCTGGGGGCAGCCGAGCCTGGTCCTCCGCTATACGGTGCGCCGTTGCATGGGCCGCCTGGGTGGGCACGGCTCGCGTGCACCTTCGAAGAGGCCGGCCCACCAGGCGGCCAGTCCGGATAGGGGGGCCTATCGTTGGGCGTGACATGGTTACTCGTCAAGAACAGGCGAGGCGAGACCAGCAGCCAGCTCGCCCGGCTCTTTGTGCACCACGCGCCCGACCGCCCGAAGAGGGCCCCCTCCGGCTGGGCGGCCGGAGGGGCCCTTCGAGGTGCAGGCTACTGGCGCCAGCGGTTCTGACCGGGGCCCTTGCAGGTGTACGTCTTCCCGTTCGCCGTACCGACCGCTCCGCCCGGCGAGCAGAACGCCCCCGGATGCACGGTCTTCGCACCGCCGCCTGTCGACCCGCTTGAGCTCGACGAATCGTCATGTCCCGTTGAGGTCCCGGGGCGCTCGTAGTCGGGATCGTTCGCCGGGATCTGGTACGTGGTGCCCTTCGTGGCCGGACAGCTCTTCACCAGGGACGCCTCGCTCCACCTGCCCAGATCTAGACGGACCGTGGTGGTCGAGGTGACCTTGCCGTCCTTGCCCGGGTCCTGGAAGCAGACGTGCCACTCCTCACCGTCCTTCGCGGCCTGCTCCGCAGTGGGCGTGTCCGTGTCGAGGTAGACGTCCTCCAGCGACACCCGCTCCAGCGGCACGCCCGCCGCCTTGAGATCCGCCATCGCCTTGTTGTAGGTGGCGCCCACCACGTTAGGCATCACCGGCCACGGCAGCGCACCGCCGTCCTCCTTCGGACACGGCTCGCCCTCCTTGACCACGGAGAAGTCCACGCCCTTCTTCCCGCCGGCCAGGTCGGAGACCTTCTGGAAGCACACTGTCCAGTTCCCAGCGAGGACGACCCCGCGGGCCTCGCTGGAGGCGTCACGGTTGCCGACCGTGTATCCGGCAGCCTCGGCGCCCTTGCGTGCCTCGGTCAGCGCCTTGCCCGTGTAGTCCGACAGCTGCGGCACAGCCGCCGGGGCGGGCGTCTCCGATGCCTTCGACGTGGCAGCCGTCGTCGGCGTCGCTGCGGCCTTCGCGTCGTCCTTCTTCTTCACCGGGTGCGCGATGCCGGCCACGATCAGGCAGAGCATCAGGGTGCCGACCGTTGCGGCGATCCGCTGCCACACCTGCCACGGATGCCTCAACCCGCCCGTGCTGATCCAGATCATGGCGATGGACGCGAACATGAGGAGTATGCCGAGCCCCTGGGCGATCGCCATGATGACGGCGGCCGCGCCGATGAATCCGAGACGGACTCCCGAAGTCTGCCACCAGGGGCGTATCGGGGCCGGTGGAGGGGTGTACGGGTAGGGCGGCTGGCCATAGGCCACTGCAGACTCCTCGGTAACAGAAAGCGTCAATGTGACTGACGGATCGTAGCGATGAGGACCAACGGCGTCCGCCGCGCCCGGCATGCGGGCCATCCGCCCACGGGACGCAGGCCAGAACATCATTTGCCAGCGAGGCCGGGCGAGCGAGTAGCGCCGTGGTTCACCGCCGCCGCTCCTGGCCGCTGCGGCGCAAGCGCTCCGTCCACCGCACGCGGCGAGTGGACGGCTGGGTTTACCCGCCCCTGCCCCGCTGGTGGCTCGCGGGTCCTCAGCCGCCGCGCTGCCGACGGCTGCACGACGGTGGCCGTCACCATGAGCAGGGGACGTTAAGGGCAGTCCTCGCCGAACTTGACCACGCCGACTGAGACCTTTTCAGTGATGGGGACGGCCTTGTTCTTCGGGTCTTGGTCGCAAATCTTCCAGTTGGTCAGGAGCAGTACCGTACGTCCCTGGCCGCTGACATCGTGGAACGAAGTGGCCTTGTAGCCGTCGGCGAACCCTGCTGTTTTGAGGGCTTCTACGAGCAGGTCACCGGACTTGCCTGTCATGTCAGGGACTTGCGCCGTCTGCGGTGCTGCTTCCTGCATCGGCTCGGGAGCCTTGGCCACCACGGGCGGGGGCGCGGTGACCGTGACGGTCGCGGTGACCGTGACGGTGACGGTCGGGGCGGGTTTGGCCTCGGCGGGCTTGGCGTCGGAAGGTGAGACCGCGGCGGCGAACATCGTGGCTATCAGGAAGAGGGCGATCATGCCCCCGCACCCGAGGACGGTCTTCTGCTTGGCGTTGAGCTGGCTGTCGGGCTTGCCAGGGCCGTTCGCCAGCTGCGGGGTGAACGGCTGGCCGGCCTCCGACGCTGCGGAAGCGGGCACATCATCGGGCCGCTGAGGGTGGCCGGGGGCAGGTGTGGGCGCAGTCATGGATTGCTCCTGTGGCAAGTGAGAGGGAAGCCCCAACTTGGTGCGGTGAAGTGGGGTTCTCACACTGCCGGGAGCTGGCGGCGCTCAACATACACGTTGAATACCGAACAACACCAGATCACGCAGCCACCGCAGCGGCACGTCTAAGAGGGCGGTTCGTGAGGTCTTGAGTGGCTTTGTCGTCGCCTGATGGTATGGGTGCAGGGCGGAATCCGCCGGTCCGCAGCCGGGGGCCTGCTGGTGTGATGATGTGAGTGAACGCAAGCCGTACCCGAGCGACTTATCGGACGAGCAGTGGGCGTTGATCGAGCCGGTGATCACCGCGTGGAAGGACCGGCATCGCTCTGTCAGCGGTCACCAGGGTGCCTACGCGATGCGGGAGATCGTCAACGCGATCCTCTACCAGGGCCGGACCGGCTGCCAGTGGGCCTACCTCCCGCACGACGTGCCGCCGAAGAGCGCGACGTACTACTACTTCGCCGCCTGGCGGGACGACGGCACCGACCAGGTCATCCACGAGCTCCTGCGCTGCCAGGTCCGTGAACGAGCTCGCCGATTAGAGGATCCGATTCTGGTGGTGCTGGACACCCAGAGTGTCCACGCGGCCGCTGGGGTCCCTGCGGCCACGACCGGCCGGGACCCGGCGAAGAGGGTGCCGGGCCGCAAGCGGGGACTGGCCGTGGACGTGCTGGGCCTGGTCATCGCCGTCATCGTCCTGGCCGCGAACACCCACGACAACGCAGCCGGCATCGCCCTGCTGGACCAGGTCGCCGAGCACACCGGCGGCACTGTCCGCAGAGCCCTGGTCGACCAGGGCTTCAAGACGGCCGTGGTCGCTCACGGCACCGCGCTCGGCATCGACGTGGAGATCGTCGAACGCAACCCGCAGGAGAGGGGGTTCGTCCCGCAGCCGAAGCGGCGGAGGGTCGAGCAGACCTACGGAATCCTGATACTGCACCGGCGCCTGGTCCGCGACTACGAGCACCGCCCTGCCTCCTCGGCATCCCGCGTCTACTGGGCGATGACCCAGGTCATGGCCCGACGGCTCACCAACGCGAACACCCCCAGCTGGCGTGATCCCGCAGGCGGTGGCAGCGTGAACATCGAGCCCCTCCTCGACGCGCTCGTCGTCCAAGAGGACGCCGCCCGGGCCCTGGCCGACGGCCTCCGCACCCAGATCGAAGAGCTGCACGGCCGACTGCGGGAAGCCGAGATCCACCTCGAACACCTGTCGATTACCCGGAAGACCGTCACGGCCCTCGCCGACCGGCTCCCGGCCGCCCCGCCGGACCTGCCCGAGCACCCGGACTACCCCCGCATCCTCGCTGCCTTCAACGAGGCCACCAGCCCGCTCCGGGCCCGCGATGTCTGCGAAGCCCTCGACCACGAACTGCTGCAAAAGAACATCGAGGGCACCCGCGCCAAGCTGAAACGCCTGGTCAAGCTCGACATCCTTGCCGAGGTCGACACCGGCAGCTTCACCAGGAAGCAGCAGGCTGCCGGGCACCACGACCAGCAGCTGTGACCCCGACCGATCGGCCACCCCGGATCGGCGCCCCTCTTGCTACCAGATCCACATCCCGCCGAGGACAGAAGCCCGACCGCTCTCGTCGACGTCGACCATGTGGGCGGCCTCGGGACCGCCGCTTGAATCGGAGTCCAGCGGGATGACGAAGCGGTGCTCTCCGAAGTCCAGGGCGAGAATCCGGTCCGGATCCAGTTCATAGCCGTCGACGGTCTCGCCGATGTAGCAGCGCATGAGCTCCAACGACCCTGGTGCGGGAAAGCTCCACTCGCGGCCCCCGTACACCCCCGAGGGGTCGCTCAAGGCCCGCAGAATCGGTCCATCGAAGTGCAGCTCGACGTAGTCGCGCACGAAAGACACGTCGCTGACCTCCAAGCCCATCAGCAGCTGGAGCGGGTCGTCCGAGTCGTTCGCATGAGTCACAAGCCCATGCTGCCAGAGGCCTCCGCCCGCCCTATCACGCGTCCGCCCACTGGCCGGCTCGGAACCGGAACGACCAACTACAGGTCGACATCACAGCAGCCCCCTCCCAGCCTCACCCGGCAATGGACATCAGCTCACGAACCGCCCTCTAAGAACTCCTAACGGAATGACCTCATAGCGCCTGTTGGTGAGCACGGTTGGTACTGTCCGACCGTGACTTTGACTGACCTGCGGGATGGCTTTCGCGATGATGACCAGCGGCAGTGCGTCCAAGCAGTCGTTCACAGTCGACTCGCGGATGACCGGGAGCCGCAGGAGTGTCGCTACTTGATGCGCTTCTGGTGGCAGCTGAGCATGCCGTACCAGGAAGTTTCGCTTGAGGAGCTGCGCCTGAACGTCGGCAGGCAGAAGCTGGACGCCCTCATGGAGCTGATCAGCGCCATCCGGTCCTCCCACGACGAGATCGATGCGTGGCTTGCTGATGCGGAGAAGACGTTTCCGGTGATTCAGGACCGCGGCTTCAGCTCAGACCGCAGCGACTGAGGCACGAGCTTCGTCAGGCGCCGCCAGCAGATGATGCAGCAGGCGAGCTTGAAAAAGGCTTCATGGATGTCATCGCGGATCTCCCACCGGATTGCAGGCGGCGGAACCAGTGCAGATGGGCGAATGCGCGCTCCACGACCCAGCGGCGGGTGCCGAGCCCGGAACCGTGCTCGGTCCCGCGGCGGGCGATCACCGGTTTCACCCCAAGCTCCCACACGAGACGGCGGTACTTGTCGTGGTCGTACCCGCGGTCACCGAGCCCGACGTCCGGGCGACGCCGGGGCCGGCCGCGTTTGCCCCGCACCGACGGAACGGCTTCGAGTAGCGGAACGAGCTGGGTCACGTCATTGCGGTTGCCCCCAGTCAAGGTGACAGCGAGCGGGATGCCGGTGGCATCGGTGATCAAGTGGTGCTTGCTGCCCGTTCTACCCCGGTCGACAGGGCTTCGTCCGGTCTTGGAGCCCCTTTGTCGGCGTACAGGTGGACGTGCGCCACCTCGTACGAGGGAAGGTGCTCCGTTTTCGGGGCGGTGACGGGGTGCTGGCGTGAGGCTGTTGTCGTCCGTTCGGGACGGCAAGGAGGCGTCTGGCAGTGGTCTTGGACCCACATCGCTGGCTGGAGTTGAGGCGGTTCCGCCCGCTGTATGCGTCTGGTGCGATGAGCCTGCGGGAGATCGCGAAGGAGACCGGGCTGAACCGGCGGACGGTCAGCAAGTATCTGAAGAATCCGGCGTCGGCGGGGCTGCCCAGGCGGGAGTCCGATGGCCGTCAGCCGCGGCGGGTCGTGGACGAGATCGCGCCTCTCATCGACGCGATGCTCAGGTCCGAGGTGCTCCTGAAGGGGTCGGTGATCCACGAGCGCCTGGTCGCGGATTACGGGGTCGCGATCAACTACCAGCGGGTGAAGATCTATCTGCAGGAGGCCCGGCCGCGGATCGCGGAGGAGTTGGGTATCAGCCCGGGCGAGCTGGCGGGTCTGCACCGGCGTTTCGAGGTGGTTCCCGGTGCTCAGGCCCAGGTCGACTGGGGTGATGAGGGCAGGGTCCTCGCTCATGTCGGGATCCCGAAGGTCTACTCGTTCCATATGACGCTGTCGTACTCGCGTGATCCTTTCTGCTGCTTCACCACCAGCCAGGATCTCGCGACGTTCTTCGACTGCCACCGCCAGGCCTTCGCGCACTTCGCGGGGGTGCCGATGAGCATCGTCTACGACCGCACGAAGACGGTCGTGCGCCGGCACGTCGCCCCGGGTGAGGCCGTTCCGCTGCATCCGGAGGCGGTCGCGTTCGCCGGCCACTACGACTACGACATCGACGTGCTGGCGGCCTACCGGCCGCAGGGCAAGGGCAGGGTCGAGCGCCAGGTGAACATCGTCCGCGATCATGTCCTGGCGGGCCGGGCCTTCTCCTCGCTCGAGGAGATGAACGCCGCCTTCGCGGCTTGGGTGCCGTTGCGGCGGGCGAAGGTCCATTCCACCCACGGCGAGGTCATCGGCCATCGGGCCGCTCGCGATCACACAGCCCTGCGGCCACTGCCGGGAACTCCGTATGTGGTTGCCCAGCGGCATCTGCGGCACGTCGGCAAGGACTGTCTGGTTGCTTTCGATGCGAACCTCTACTCGGTGCCCGCCCGCAAGGTCCGCCCTCGCCAGCTGGTCGAGGTCCGGGCGACGAAATCGCAGGTCAGTCTGCATTCCACCGTCCCCGATGCTGGCGGGCTGACGCTGCTGGCCGTTCATGCGCGGGCAGTCGGCCGCGGAGCCCACGTCGTCGACGAGACGCACTGGGACGGTCTGCCCACCGGCGCCGGCCGCCGTGTCACCACTGGCGACGCTCTGCCTTCTCCCCGCCGCGGCCGGCCGACAGGTTCGCAGACCGGACCGCTGCAGGCTCTTCTCAGCAGGTCTGCCGCCGCTCACGTCGAGGTCGGCCGCCGCCCGCTGTCGGTCTATGACGAGCTGACCGGCACCCGGCCTTTCAATCCGCCCGCCCCGACCAAGGACGCCCGTTGAGCGAGCTGACCAGCACCCGCATCCGCACCACCGCCACCCGCCTCGGGCTGCCGCACCTGGCCGAAGCCCTGAGCCATTACATCCAGCGGGCCGACGAGGCGAAGATGGGCTACCTCGACCTGCTTGACCTGGTCCTCTCCGAGGAACTTGCGGTCCGTGACGACCGCCGCTTCCGCAACGGCCTGCGGCTGTCGAAGCTCCCGCACCACAAGACCATCGAGGACTACGACTTCTCGTTCCAGCCCGAACTCGACCCGCGCAAGGTCAAGGACCTGGCCACCTTGTCCTTCGTTGAGGACAAGGCCAACGTCGCCCTGCTCGGGCCACCCGGTGTCGGCAAGACCCACATCGCCGTCGCACTCGCGGTCGCGGCATGCCGAGCGGGCTACTCGATCTACTTCACCAGCCTCGACGACATGGTCCGCCACCTCAAGGCCGCCGAGGACCAGGGCCGGCTGATGAGCAAGCTCACCAGCTACCTCCGCCCCGCGGTCCTCGTGGTCGACGAAGTCGGCTACCAGCCACTCGAGCGAACCGAGGCCAACCTGGTCTTCCAGGTCATCTCCAAGCGCTACGAGAAGGGCTCGATCATCCTCACCTCGAACAAGACCTTCGGCGAATGGGGCCAGGTCTTCGGCGACGAAGTCCTCGCCACTGCAATCCTCGACCGGCTCCTGCACCACTGCGAGGTCGTCTCCATCAACGGCAACAGCTACCGCCTCAAGAACCGGCTGGCCGCCATCGAACGAGACCGCAACGACGCAGCCTGAAGGCAGCCTCCCTATCGGCCGGACACCTCGAGGGCCGGTCCGCCTTGCTCTTCCTCAGCCCTCTTCAAAGCTCTGATTTCACGGCGGCGCCAACGTGTGACAGCCGCAACGGCGACCGCCCCACCCAGCAGGGTGACCAGAGGAATGCCCCAAACCGCGGCCATGAACAGGTTTCCGAGTGATTCCATGACGCCCCCTTTCGACGGGACCTTACTCGCTCCCTGAAGCGGCTTCGGCGGCAAGGATTGGTGCACAGATCTCCGTACTGGGTTGAGCACTCTCACGAGTACGCCGACAGTCGCGTCGCCGGCGGTGAGGGCGGTCAGTTCGGCGGGGTCGGTGGTCAGCGGGATGTCGGTGCCGACCGGTTCGTGGTCGAGGGCCTGGCGGGCCGAGCACACCGCCACAGTGGTGCCCTTGCGGCCGGCCAGACGCCAGGAACGGATCGTCTGCGACAGCAGGTCCACTGTCGGCAGCAGCACCAGCACACGGCCACGGGGGGGCAATACGGGCGGTGGTACGGGCGGCAATGAGGGTCTTGCCGGTGCCGCAGGCCGCGATCACGCTCGCGCGGGCGTAATCGCGGAACGTGGCGGTCGCGGCGGCGACGGCTTCCTTCTGGTGGGGCCGCAGCTCGATATCGGAAGCCATGAAGGTGTGCTGCTCCGTGGAGTTCGGCTGGACGGGGGCGGACAAGGCGCCCCGCCCTGTCAGGGTGCAGGTTATTCGGCTGCTTCGGTCAGGTGGGCGAGGGTGGATCCAGCGGGGCTTTTACGGACGTGCAGGCGGTGAGTGATGCGGCGGCGCAGTTCGGGGACGTGGCTGATGACGCCGACGGTGCGGTCGTGGGCACGCAGGGAGTCCAGGACATCGAGGACCTTGTGGAGGGTGTCTTCGTCGAGAGTGCCGAAGCCTTCATCGATGAAGAGAGTGTCCAGGGGGTTGCCGCCGGCTTCGTGGGTGACGACGTCGGCCAGGCCAAGGGCGAGGGACAGGGAGGCGAAGAAGGATTCGCCGCCGGAGAGTGTGTCGGTCTTGCGGGGACGGCCGGTCCAGGAGTCGGTGATCTCCAGTCCGAGGCCGGAGCGGGCGCCGCGGGCGGCTTGGTGATCGGAGTGGGAGAGGTTGTAGCGGCCTTCGGACATGATGTGCAGGCGGGTGTTGGCGGCGGTGACGACTTCTTCGAGGCGGGCTGCCAGGACGTAGGCCTCCAGCTGCATGCGCACCCGGGCGCTGGGTGAGTTGCCGGTGACGAGTTCGGCCAGGTGGCGGGCGGTGAGGTGCGCCTGCTCGAGCGGTTGCAGGCGCTGGATGGCGGTGCCGAGGTTGGCGGCAAGGGCGGTGAGGGCCTGGCTGCGGGTGTGGGCGGCACTGGCGGCGGCGGCGGCCTCGGCGTGCTGGTCATCCGCGGTGGCCCTTGCAGCCGTGGCGGCGTCGAGGTTGGCGGAAGGCTGTGCGGCGGCCTGCTGCAGTGCCGGGTTGTCCAGGACTGCGGTGTGCGCGGCACATGCCTCGCGCCACTGAGTGATCTCTTCTTCTATGGCGCGCAGGTCTTCGTCGTTGAGCAGGGCCTGCTGGGCGAGTGCCAGGGTGTCGAAGCCCTGGTCCTTGGCGGCGAGGGTGGCCTGGTCGGTGCGGTGCGCGAGGGTCTGGACGGCGGCGGCGAGGCTGCGGGAGGCCTCGGCGGTCTCTTTGAGGCGGTGGGCGGTGCGGGTGAGGTCGTCGGCGTGGGCGGCGACAGTGGGATAGGTGCCGCGGGCCGCGGTGAGCTTGGCCGTCAGCTCGGTGAGCTGCTGGGTGAGGGTGTCGTAGTGGGCGTTGCGGGCGGACAGGCCGGCCGTGGCGGTGCTGTGTTGCTGGGTCTGGGCCGTGTGCTCGCCGTCGAGTGCGAGGAGTTCTTCTTGGACGGTGCCCTGGTCTGCAGCGCGGTCCAGGACGTCGGTCAACTCCGTGGTGAGCGTGGTGTGCTGGGTCTGGAGGTCGGTCAGGGGGGTGTCGCCGGCTTCACCGGCGGCGGTGGCCGCCTGTTCGCGGAGCCCGTGCAGCACGGCCGCGGCGGCTTTCTGGGTGGTCTTGGCCTGCTCGTGGAGGGCTTCCGCGTCCTGCTCGTCCTGGCGTGTGGGCTGCCCGTCCTGGGCAGCGGCGGGCGCCGGGTGGGTACAGGATCCGCAGACCGGGCAGGGCGTGCCGTCGGTGAGGGTGGCGGCAAGTTCGGCGGCCATGCCTTCGGTGCGCCGGCGGCGGATGGTCAGGTAGTCCTGGCCGGTCTGGCCGGTGACCGCTTCTGCATCGGCCAGCTGCTGTTCGGCCTTGGTGACCTTGGCGAGATGCGTGTCGCGGCGCCTGGCTGCTTCGAGGCGGGTTTTGAGGCCGTCCAGGGCGGTCTGGTGGCGGCGGCTTTCTTCTTCGGCCTGGCGGGCGGCTTCTCGCCGGGCTTCGAGGGCGCCGCGCCGGGCGGGCTCGGCTTCGAGCCAGTCCTGGGCTGTGCGTTGCTGGGTGGCGAAGTCCTGCCGTTCGGCGTCGGTGCGCTCCAGCTCGGTGGTCAGCCGGCGGACGGTGTCTTCTTCGGGGATGAGGGTGGTCAGGATGGCAGCTTCGGCGCGAAGACGATGCTCGGCGGTTTCCAGCCGGCTGGCGTCAAGGTCCTTGTGTTCGGGCAACAGGCGCTCGCGGGCGCTGCGTTCAACGCTCTGGGCACGGGTGTGGTCGTGTGCGGCGGTGTCCGCGGCGTGCAGCAGTGGTGCTGCCTGTTGGGCGCGGCGGGCTTGGTCGCGGCGCTGGATGAGTGTGTCCTGGTGCGGTGTCTGTTCCTGGAGCAGGTCGAGTTGCTGCCGTGCGCTGGTGTAGGTGGTTTGCTGCTGGTGGAGTTCGCGGGCCGCGGCTTCGAAGGTCTGCTGTCTGGCCAGGTTCTCCTTGGCCGTTGTGGCTGCTTGGAGTGTCCTGGCGTGGTCGGTGTGGCTGACGCGGAGGAGATCCTGGGCCCAGGCGCGGGCGGGCTCGGTGAGCGTGTTCGGGTCGTCGGGGGTGGGCGCCGTGTACTCGGTTTCCAGGTCGGGTCCGGCTGCCTGGTGGATACGTTCGGCTAGGCGCAGCACGTCGGCGCGGGTGGCGTCGCGGTTCTTCTCGGTGGTGCGGCTGTGGTCGTTCAGCCAGCGCTCGATGAAGGAGAAGCGACCGGTGCGGAAGAGTTTGCCGAGGAGTTCTCGTCGGCCGTGGGCGTCTGCGTGGAGGAACTTGGTGAATTCGTTCTGCGGCAGCAGGACGACCTGGCAGAACTGCTCCCGGCTCATGCCCAGCAGGTCAGTGACCTCGACGGCTGCTTCTTGGTGGGACTTACTGGAAGGTTCCCAGCGGCCCTGCCCGTCGGCGTCGACGGCCCATTCACTGAGCCGGGTTTCTGCTTTCTGGGAGGTCTCGCCTTCACCGGATCGCTTGGGGCGCATCTGGGCGGGGATCCGGTCGATGCGCAGGCGGCGCCCTGCAAGAGTGACTTCGAGGGTGACTTCGGTCAGGAGGCCAGCGGGAGCGTGGTGGCTGCGCAGCAGCAGGTCGCGGTCGCCCGGTGGTTTGCCGTAGAGAGCGAAACAGATGGCCGCGAAGATGGTGCTCTTGCCCGCTCCGGTGTCGCCGTGCAGGAGGAACAGGCCGTCGGCGGATAGTGCGTCGAAGTCGATGGTGTGGGTGCTGGCGAAGGGTCCGAATGCCTGCAGGCGCAGGGTGTGCAAGCGCATGTCAGACGGATTCCTTCTGCTGCTCGTTCAGGCGGGAGGCTTCGACCGCCTGCTGTAGCAGAGCGTGTTCGTCCGGTGTGGGGTCGGTTCCGCGCATGCTGCTGATGAAATCGCTGGCGATGTCGAGGTCGCCGCGGCCCCGGATGCGCTGACTGTAAGTGGGGGTGTTCGTGGCCTGGGAGGGTATAAAGGCGGGCTTGTGCCTGAGGCTGGCGGTGTGGGGGAAGCGGCGGCGCAGGCGGGCCATGGCCTCGAAGGGCAGGGCCGTGTCGGTGAGGGTGACCTCGAGCCAGGCATCCTTCAGCGGCTCGTGGTCGGGATTGGTCAGGAGGTCTTCCATGAAGCCGGACACACGTTCCAGGCGGAGAGGCACAGGGCAGGGCTGGCGGGTGAGGGCGGGAACGGCATTGGGGGTGAGGTCGACAAGGGTGATCGACTTGGTGTGGCGGGCTTCGGAGAAGGAGTAGGCCAGCGGGGAGCCGCTGTAGTGGATGCGGTCGGTGACACGCTGGGGGCCGTGGAGGTGGCCCAGGGCCACGTAGTCGATCCCGTCGAAGACGTCGGAGCCTACGTGTGCGACACCGCCCACGGCGATTTCGCGTTCGCTGGTGGACTCTTGGCTCTCATCGCGTTCCTCGGGCTGTCCGGTGCCGGAGGTGACGAAGGCGTGCGCAAGGACCACTGACCGGGTACCGGCCGGCTGGTGGTTGGTGAGGTCGGCGTGGATGCGGTCCAGGGCTGCGGTCAGTACTGCGCGGTGGGAGACGGCTTCGGCTTCCAGGCGGTCGCGGACCATCGACGGCTCGAGGTAGGGGATGCCGTACATGGCGACGGGGCCGTCGGCGTCGTCGAAGAGGACCGGGATGTCGCAGGTGTCCGGGTCAGTCCTCAAGTGGATCCCGGCACGGGCGAGGAGCCCGGATCCGACGCCGAGGCGGTGCGCGGAGTCATGGTTTCCGCTGATCATGATGATCGGCACGCCGAGGTCGGCGAGCTGGTGCAGAGCGCGGTTGAACAGGCGCACGGCGTCCAGGCTGGGGATGGCCCGGTCGTAGATGTCTCCTGCGACAAGGATCGCGTCGACATCCTCGGTTCGGGCAGTGTCGACCAGGTGGTCGAGGAAGGCACGCTGGGCGGGGATCAGGTCTTCTGTGTGGAACCGGCGGCCCAGGTGCCAGTCGGATGTGTGGAGAAACCTCATGCGCTTACACCTCGGCTTTGTCGCTCAGCGTGATTGTCAGTGCTCGCAGGGAAGATGGAGAGCGTGGGAAGGAGGAGAGATGCCCTCTCCAAGGTCTGCTCGTGCTGCCTGCGTTCCCTCGCCGGGGGGGTGCAGGTGGTGTGGGATCGATGCTCGGATCCATGCTCGCCAATGGGTGGAATCGGTTGGCTGGCATGTGTGGCAGACGCCGACGGACGAGCAGCGCAAAGAGCGTATGCGGGCGCGTCGTGCACGGCGGTCGGCGCCGGATCAGTGAGCGAGTTCTTGCAGGTGGGTGAAGATGTCCCGTAGCTGCCGGGGCACGTCCTGGGCCGTGGTGAGGGTGCTGGCCAGCCCGTAGACCATGGCGGGTTTGCCGTTGGGGCTGTTGTTTCCGGCTTGGTTTTGGATCATGTCGAGGATACGGGCGCTGAATTTCTTGCCGTCGCGGTGAGCCGTGAAGTCGTGGGCTTGCCAGGTCTGCGGGGCCGGGCGAGGCCAGTGGGTGTTGGCGGCAGTGGCCCACTGCTCGTCGCTGAAGAGTTCTTCCAGCTCGTTGTAGCCGTCGGCTTCTCCGACGTAGGAGACGTGCTTTTCGAGGTCGAGACCGGCGCGCCGGAGGCGTTCGTCTTTGAAGAGTTTGTTGGTGCGGCTGTCTGCGTCCACCATCAGCATCACTGTGCGTTGATGTTTGACGAGGTAGCGGGCCAGGTGCAGGGCTCCCTCGTTGTTCTCGCAACCCCACAGGGCGATACCTGCTGCCTGGAGGGACATGTTCTGGGCCAGGCGGAATAGCAGCGGCAGGCTCTTTTGTTCTGTGTCGCCCTCGACGGCCAGGAAGCAGCGCTCGTGGAGCAGGACGGAGTTGCGCAGACCCAGCGATGCCGCGATCTGGCCCAGGTGGAAATCAATCCCGTCGTGCTGATCGTCATCGAGCCGTTCGACGACGGTGCGCCCGCCAGGTCCAAGGCTCAGGTGGACGACATCGGCGATGTCGACGCCGTCGATGAGGTTCATCGAGTGGGTGGCGACCATGACGCTGACGTGGGGCAGGGCGCACTGCTTGCGGATGATGTCCATGACCGTGCGCTGGTGGCGGTAGTCAAGGTGGGTGTCGGGCTCGTCGTAGACCACGATGGTCTGCGTAGGTTGGGTGTTTCCCTGTTCTGCCGAGGCGGCCAGTTCGGCGTTCTCCAGGAGGTTGCTGGTCCACTCCCATACCGCCAGGGCGATACGGCGTGTGCTGCCCTGCCCGGCGCGCGTCAGGTCGACAGGTTCGCCGTCCGCTCTTGAGACGTGCAGCGGGGCGCCCTGGAAGCCTCCCTTGAAGGAGACCAGGGGTTTCACGTTTACGCTGACGTATTCGGCGCAGTGCTGGCGGATGTGGAGGCACAGGGAGTCGGCTTCCTTCTCCAGCCGCTGGGTGATCTCTCCCTCGATCTCCCGGACGCGGCCCTGAAGAGTCTCGTCCTCCAGGTGCGTCTTGTAGCTGCTACTCAAAGCGGTGCGCACGGCGTCGTCGGGGCTCTCGTCCTTCCCACCGAACGACAAAAGCTGCGGGAGTCGTTCCTCGAGTGTCTTGGGGAGCGGTTGCCACCCTTCGTCCTGGGGCAGCGTCCTGGCGTGTGCCCTCAGCTCTGCCAGCAGATCCTCCTTGAGGTTTCCTGCCGGGGACAGCCCGTATTCGGCAACAAGCGCCGTCAGCGCCGGTTTGAGCAGTCGGCCCAGGTCACGCAACTGCGGGTCGGCGGGCTGGCTGCCGAAATACTCCAGGCAGGTCGCCTCCCCCAGCAGCGAGCGCCGACGGATACGCACACATTCGCCAAGCCCGCTGTGGGCCTGTTCCTCGGCGTCCAGCCGGAACTGGCCCTCCACCCAGGTTTCGGCGCACCGCCGCCCCTTGGAGCCCTCCTCGTCCTGCACATAGGTGCGGTCTTCGTCGGTCAGGCGGTGGGTGCCGAGGAGAAAAGCCAGCGCGGTCAGCACCGCGCTCTTGCCGCCGTCGTTGCGGCCGGCCAGGACGGTGGGCCCGCTGACCGGGATGTCCGTCACCTGGGCTAGGGAGCGGAAACCGCGCGCGGAGTAGCTGTCGAGATACACGGGAGGAGCTGCTCCGTATCTCCCCGTCCAGAGCGGACAGAGGCGTGGCGTGCGGCAAGCGCGGATGCTGATGAGGCACCTGTGCCACTGGCACAGGCCGTCATATTAAATGGCGTTGAACAACTATGGTGTCTTTTGCGTCAGTTGAACCAGCGAGTAGGGTCGAGCCCCCCGCCGTGGGTACGCTCACACCTCTTGCTCAGGCAAGGCATAGGCGGACCGCTTCTTCGCATGCCTGATCGATTTTGGGCAGGGGGTGAATTGGCTCGGATTCGACTATGGGGTCCGACTGATTGGAGGTTCCAGCCCGGGCACTAAGAGGTCATCGCGGCGAAGGCCGAGCACCGGCTGCCCCGGCCCACGATGAGGAGGCGGCGACGGCCCCGGTCGTGGACCTGATGGCCGCGCTGGAGAAGTCCGTCGCCCACGCCCGCGAGCTGCGCGGCGAGACCGACGACAAGGCCGGGGCTGAGGCGACCGTGCACGAGATGCCGGCGCCGAAGAAGAAGGCCGCGAAGAAGGCACCGGCCAAGAAGACCACCACGAAGAGTGTTCACCTCGGCCGCGGTGAAGTCACGGCCGACCAGGTCCGGCGCTTTCGTCGCGGCCGGGTCCGCGACGGTGGTCCGGTGCCGACGACGCAGACGGACCCCCTCGATCCCGATGGTCCGCATGATCCTCGCGACCCGCTTGTGGTTGATCCGTTCGCCCTCGTCGCGGAGCTCGGCCGTGATCCTGGGGGCGCCGTAGGTGCCGTCGGATTCCTCGTGGACCTTGCGTATCCGGGCCGCGAGCCCGGCCTCGGCGGCCTGCCGGGCCGTCCGCGCGGCCGCGGTGCGGCGCCAGTAGTAGAAGCTCGAGCGGGCGATCCTGAGGAGGTCGCAGAGCCGCTTCACACCGAACCGGCGCTGGTGATCGTCAACGAACTGGCAGCGGTTCACCAGCGCGTCTCCCCTGCGAAATACCGGGCCGCCTTGCGGAGGATGTCGCGTTCCTCCTCCAGCTCACGAATCCTCTTCCGGGCGGCAGCCAACTCCGCCTGGACGGCGTCACCACCGGACTGCGCAGCGGCCGGGGGCGTAGAGTGGGCACCGGAACGGCGCCCGTCAGCGGCCCGGATCCAATTCCGCAGCGTCTCGGTGTTCACCCCGAGGTCAGCGGCGACGGACTTGATCGTCGCTCCCGGCCGCGACTGGTACAACGCGACCGCGTCCGCCTTGAACTCGGCGGGATAGTGCTTCATCCCCACAGGGACTCCGTTCTCCTGGACCATCAAGATCCAAGTCTCTCCGGTGTCCAAAATCCGGGTCAGGGCCCAAGGCCGGGTATTTAGCGCTTTCGCTGGTCACGCAAGGGGAGTTGGGGTCCATGCTGTGGCGGCGTAGAGGCCGGGGCCGAGTTTGTGGATGAGGCCGGTCTCGGCCCATCTGGAGAGCTGTCGATACATGGTCTCCACCCGGGAGAACTGCGCGCGTGCGGGCGACGCTCGACTGGATCGAGACTGCCGTGGACACAGGGAAGGTCGACGTCGACGGCGAACTGGCCCGTCTGCTGCAGGGCGAGTAGTGGGATGCCGCGCGCGTCACAGCGCCGGTCCCCCGCGGCCCAGCGGCACGCCGACACCCTCCGGTTCGTGCTCTTCGAGGCGCGGCCTGCCGGTCTGGCCTTCAAGCAGTTGGTCAGGTCCAGCGAACTCTCACCCCATCAAGCTCGTGCGGGCCTGGCCTGCCTGCGCGACACCATCGCCGAACGGGAATGGCCGCCCCTGATCTGGACGAAGGCGGCGGCTACAAGTTCTGCTCCGACCCCAGCGAGCTCCAGGCCTATGAGGTCGCGGTCATCCGCGAGAGGCTCACCGAGATCCGCCGGTTCATCACCGGCGTCGTCGCCCGCACACAGTCCTGCAGCCCAAGGGCCGGTGGATCCGGCACCTGAACACCCAGCTGAACTCCGTCGAGTCCACCCTCGATGTGATCGCCGACTACATCGACGCATGATCCTGGTGAGGGCCGGCCGCGAAGCGGCCGGCCCTCACCCTCGTTGGAGGGAGGGGACGTTGGCCCGGCATCGCTGCTACCCCTCGGACACCTATGACGACGAGTGGGCATTGATCGAACCGCTCCTACCGACCCCGGCCTGCGAGACCCCTCGTGGCGGGCGGCCGGAGAAGCACCCGCGGCGCGAGATCGTGGACGCAATTCGGTACGTCGTCGACACCGGCTGCAAGTGGCGGGCCCTGCCCAAGGACTATCCGCCCTGGCGAACCTGCTACAACGCCATGGCCCGCTGGGCCGCCGCCGGGGTGATCGGGCAGATCCGCGATCAGCTCCGCAAACGCGTCCGCCGGGACATGGGACGCTCCCCTGGAGCGGTCGCCACCATCATCGATTCCCAGTCCGTCAAGGCCGCCGAGACCGTCGGCAAGGACTCACGCGGCTACGACGCAGCGAAGAAGATCAACGGCAGGAAGCGGCACCTTGTGGTGGATACCAAGGGCCTGCCGCTGTTCGTCATGGTCACCCCGGCCGACATGACCGACCGCGACGCGGCCAAGGAAGTCCTGTTCAGGCTGAGGCTCATGCACCCCGAGATCACGATCGTCTGGGCCGATTCCGCCTACGCCGGACAGCTCGTCGACTGGGCGAAGAAGTACCTGAACCTGACGTTGAAGACCGTCAGCCGGCCGAAGAACGCGGTCGGGTTCGTCGTCCTGCCCCGCCGCTGGGTGGTCGAGAGGTCGATCGCCTGGGTCATGCACGCCCGCAGACACGCCCGCGACTATGAACGCCTCATTTAACACTCAGAATCGCTGATCACCTGGGCCGCGATCACCCTCATGACCAGGCGAATCACCCGCCGGCAGTCCCGCCGGGCCAGCCGGCCGCCCTCCCGCGAACACACACGCGACTGACCGCGGTCACACCCGCGACCGCCAACTCCACTCCAGCACTTCTGCCATGCCCGGATCGGGAGCCAGGTGCCGAGTACTTGGTACTCAGAACCCGTCGCCCCATCCGAAGGTGACGTTGTACGCACGCTGGAGTGCGTGCCGGCCATGGTCACCGTCGACGTAGGCCCACGCAAGGGCTGCGGCGAACCAGAGCACAAAGACGCCGCTGACGATGCCCAGAGCGATCAGCTCGCCGTACCAGCTGAGGAGGACCAGGGCGACGGTCACGATGACCGCGCCGAGGTGGGCTCCTCGCGAGTCGAGCGACGCAGCCTTGCGCGCCTCTCTGCGTTCGGCCCGTTCGGCGGTGAAGCGTTCCTCTCGGACAGACTGCGGTTCGTTCTCGTCGAAGTTCATCTCATTCCCCTGGCCCTGACGCTACATGGACCCGGACCACGTCGGCAGTGGAGTCCAGCGTGGGATAGATCCGACACTTCAGGGCCGCCCTGGGCGTGACGGCTACCGGCCCGGCGCTTGAGACGGGCCGGGTTTCCTAGCTCGGTGCGACCTGCGCTTCCGCACCTACGCGTCGAGTTCCGGCAGGCGCTCACCAGGGGTGGCTGGGCGGCCTTCGGACAGCCAGAACATGTAGTCGCGAAGATACTCCCCAAGGCCGTGGTCCAGGTGGGCGAGGTACGCCCGTGCCCCCGCGGCGGCGTCCCGGAACTGCTCGCGCTCGGAGGTCGCCCACTCGCCCCACCCCACCCTTACGGCCCATTCCCGCGCTCTGCGGCGCTCACTCCACCAGTCCTGGACCAGCTCTGGGGTCCAGTGACGGTCGCCGTCCCCTCCGTACGCCCCGAAGGGGTCGCACTCCCCGGCGCAGGTCAACTCGTGGACGCCGGCGACCTCGACCGGCTGACGGTAGACGAACTCGGTGCAGTACTCGTCCTCGTATGCGACATGCTCCGGCGCGCACTGCCTGCCGGTGAAGCAGTTGTCGGTGCCGGCCGTGTAGAAGGGACCCGGGACGTTCCGCCAGTCCCTGTTTTCCCAGCCATCGGGCGCGGGCCCGGACCAGTCGTGCCGCACAAGGCCGTCCTGCCACAGCGGATGGGGCGTGCCCACCAGGACGCGGGCAGACGGTATCGGATCCCAATAGGTCATGATCCGCAGGATGCCAGATCGCCCGTACGCAACGGCCTCTAGTAGTGCTTTGTTAGCCGGTCTTGTCACGTCGGGTGTCTGGTAGTTCGCTGGTTGTATGAGGGCTGGGGAGCTTGGCGCGGTTCGGGTCGGGTTGGAGGAGTTCGCTTCCGAGGTGTTCGCGCCGTTGGTGCGGCGGGACTGGCTGGAGAAGGGCCAGCTGTATTTGCGCGGTCTGTTGCTGGATGGCCGGCGCAAGTCGATGCAGCCGATGGCCGAGCGTCTTGGGGTGGATCATCAGCGGTTGCAGCAGTTCATGACGTCCTCGACCTGGCCGGTCGAGGACGTGCGGGCCGGGCTGGCGTGGCGGGCCGTGCGGGTGGTGCGTCCGCAGGTGTGGGTGGTGGACGACACCGGTTTCCCCAAGGACGGCAAGGCCTCGCCTGGGGTGGCCCGGCAGTACTCGGGCACGCTGGGCAAGGTCGGCAACTGCCAGATCGGCGTCAGCGTCCACGCCGCCTCGGACACGGCTTCGTGCCCGCTGTCCTGGCGGCTGTTCCTGCCCGCCTCCTGGGACGGGCCGCAGGCCGCCGATCGCCGGGCGGCCTGCCGGATCCCCGCCAGCGAACATCACCGCCCGAAGTGGCAGCTCGCGCTGGAGATGCTCGATGAGCTGTCCGGTATCGGCCTGCGGCCTGCCGCACTGGTCGCGGATGCCGGTTACGGCGCGAACGCCGACTTCCGCCACGGCCTGGAAGACCGCGGGCTGGCCTACGTCCTGCAGGTCGAAGGCGAGATGACCGCTCACACAGAAGACGCCGAGCCGCATCAGCCCGCTTAGAAGCCATCTCATTTGGGCTTCGTGGGTAGGCTGTCGGTCATGGTGGGGATCGTTGAGCGTCTGGTGCCGGACGAGTTGTGGGTGCTGTTCCAGCGGGTGGTGCCGGAGGCGCCGTCGCGGCCCCAAGGTGGTGGACGGCGTCGGCACGGCGACCGTGAGGTACTGGCCGCGATCGTGTTCGTCGCGACGTCGGGTTGTACCTGGCAGCAGCTGCCCACGGCATCGTTCGGCCCCTCGGGGGCGACAGCCCACCGACGCTTCTCCGAATGGAGCAAGGCCCGCGTGTGGGCCAAGCTCCACCGCCTGGTCCTCGACGAACTCGGTTCCCGCGGCGAGCTCGACTGGTCCCGCTGCGCGATCGACTCGGTGAACATGAGGGCCCTGAAAAGGGGGATCTGACAGGTCCGAATCCTGTCGATCGGGGCAAGTACGGCTCGAAGATCCACTTGATCACCGAGCGGACCGGTCTGCCCCTGTCCGTCGGAATCTCGGGCGCGAACCTGCACGACAGCCAGGCCCTCGAGCCCCTCGTCCGCGGCATACCGCCCATCCGCTCACGACGCGGACGCCGACGACGAAGCCCGGCAAGCTTCACGCGGACAAGGGCTACGACTACGCCCACCTGCGCCGATGGTTACGCGGGCGCGGCATCACGCACCGCATCGCCCGCAGAGGCATCGAGTCCTCACAACGACTCGGCCGCCACCGATGGGTCGTCGAAAGGACCATGTCCTGGCTCGCCGGCTGCCGACGCCTCCACCGTCGCTACGAACGCAAGGCCGAACACTTCCTCGCCTTCACCAGCCTCGCCTGCACCCTCATCTGCTACCGCCGACTGGCCAAATGAGATGACGTCTTACTCAGGCCTGGGGCCCCGTCCCAAACCCCGGTATCGCACCCGGCCGGTCTCCTTACGCGACCACGTGCTGGCCGCCGGACGTCACCGGGGCCGGCCCGTGACCTGGCGCAAGGGTTCCGGGGCCGCGATGAGCTCGCACTTCGTCCGCCTGCGGATCCGCCTCGCGGGCCGCCGGCCCAAACCCGCCGCCAACGGCACGATCCCGCTGGTCTGGCTGGTCGCGCAGTGGCCCGAGAGCGAGGCCGAGCCGGTGAAGTACTGGATCTCGAACCTGCCCGCGAACATTCCCGCCAAGGACCTCGTCCGGCTCGCGAAAGCCCGCTGGCGGATCGAGCACGACTACCGCGAGCTGAAGACCGCTCTGGGGCTGGACCATTTCGAGGGCCGCTCGTTCACCGGCCGGCACCGGCACGTCACCCTCGTCACCGCCGCCCACCTGTTCCTGACCGAACAGCGGAGGAACCCAAAAGTCCCTGCCAGGGCCTGACCCTCTACCCAGGCCCTGGACCTCCTCCAACACCTCATCGCCACCTGGACCGGCACCTGCCCCACCTGCCAGCAAACCGTGCCATGGCAGCCCTACGACACCACCTAACAAAGCACTACTAGGAGCTGTCCGGCCGATCATGTGACTGTCACCTGGTCGGATCGTTCTCCCGTGCATGGGGCGGGGTGAACGCGGTGATCTGTCGGACGCGGAGTGGGAACGGCTGCGGCCGTTCCTGCCCGTGAGCAACGGTCGGTGCGGGCGGTGGCGTGATCACCGGCAAGTGATCGACGGGATCCTGCACCGGGTGCGGACCGGGGTGCACTGGCGCGATCTGCCGGAGCGGTTCGGGCCGTGGAAAACGGTCTACGAGCGCCACCGGCTCTGGTCGGCCGACGGCACCTGGGAACGTCTTCTGCAGCAGCTCCAGGCCGCGGCCGATGCGGTGGGCGAGATCGACTGGGACATCTCGGTGGACTCCACCATCGTGCGCGCGCACCAGCACGCGGCCGGCGCCCGCACCGACCCCCCGCCGGCCCTCGCCGACTCAAAGGGGGACGAGACGGGGGAACACCAGGACGAAACTCCGTGGCAGAGCCTCGTCGACCGGCTGGCGGAGGTGGTGCGGGAGGCGAGGGCCTGGGGCGTTCGCGCGGCGGCTTCACAAGCAAGATCCACCTGAGCGCGGACGGTCGCTGCCGCCCGCTGTCCCTGATCGTCACACCGGGGCAGCGGGCCGACTGTACCCAGTTCGCGCCAGTGCTGGAGAAGATCCGGGTCCCCCGGCCCGAGGCGGGCCGACCCCGCAAGAAGCCGGACAGCGCGCAAGGGATCACGAGGCGGACGGCCACCGAAATTCGACGAGGAACGGTACAAGAAGCGCAACACCGTCGAACGGGCCGTGAAGGGGCTCAAGAACTTCCGTGCGGTCGCTACGCGGTATGACCAGCGAGGCTACGTGTTCCTCGGCACTGTCTCAGCTGCCGCTGTCATCGTGTGGCTCCGCTCATGACCGGCCACTCGTGTTCAAGCCGAGTGCGGAAGCCCGGCCGACCGCGGCAAACAGGATGAGTGGCAGCTCCTTGTCGGCCTGGCCGAGCGCCAGCGCAAGCCAACGACCGTTGTCGGGGAGCGGCCACACCTGCATGCTCACGGCCTGTTGGCTGAGGTAGTCGAGCGGCTCGGGCACCGGCTCTCCCTCGTAGCTGGCGCTGAGATACGGTCCGAGGTCCGCGACGAACGCACTGCCCCACCGATCCGTCAGGCGTGCCGCCAGGTCGTCGAGGCGGGCCTGCAGTTCAGCTTCTGCCTCAACCCAGGCCCGCCCGTCGTCGTCATCCCAGAAATCCCGACTGACCTGCAGTTCGCGCACGTGATGCTCAGGTCCACCGCCCCCGGAGGCGTCGACATAGGTCACCTCCGGGAACGGCTGCACGGCCAGCGAGTCAATCGTCGAGAGGTACTCCTCGGTGGTCATGGGCGCAGGCTATGGGACCGCGCAGACAACCTCCCCCGACTGCACACACCAATGATCGGCCGGACAGCTCCTAGTCGAACACCGACCCGCTCACTCGATGGTCCTCCACCACCCAGCCGCGTACGAGAAACTGGCCCACCAGCCCGGGCTCATCGCCTTCCAGCTCCACAAGCCGCCAGGCGGCCCCTGATCTCCGCCCTGACCAGTCATGATTGCCTGCATCGGAGTGCCGCCCATGCAAAACCGCCCGACCCTCGTCGTAGTCAGCGGCCCTCCCGCCACAGGGAAGACCACGCTCGCCCGCGCCCTCGCCCAGCAGCTCGGCTGCCCGGCGATCATCCGCGACGAGATCAAACAGGGCATGGTCATGAGCACCCCAAATCACCAGCCCGCCGGCGACGACCCCCTCAACATCCCCACCCTGGACGTCTTCTTCAAGGCCATCACCGTCCTCCTTCAGGCCGGGGTCACCCTCGTCGCGGAGGCGGCCTTCCAGGACCGGCTCTGGCGACCAGGCCTGGAGCCCCTCCTGGACCTCGCCGACCTGCGCATCATCCGATGCGTCACGCCCACCTCTACCATCACCGAACGCATCACCGAGCGCGCCCGCACCGACAGCCACCGGGCGGCCCACGGCGATCAGGCCCTGCTCGCCGACATGGAAGCCGGCGTCTACGACCCCGAGCAGTTCAAAGCCATCAGCCTCGACGTCCCCACCTTGGTCGTGGACACATCGGACGGCTACATGCCCGAAACCGCCGAGATCCAGGCATTCCTGCGAACACCACCACCGTCACCCAACCCTCGGCGATAGACCCTCGGCAGGACGAGTCCGTACGGGCTACGCCGACGGCCCCGATGCACCTGAAGCTGGAAATCCGTGCGACCCATGTGCCTGACCTCTCCTCGATCGTCGACCGCACACAGGGCTTGGGTATGTTCCCGCGCCGCGCCGCGACGAGTTGGGAAATCAGGGCGACCAGGTCCCGGCTGCGGGAAGCACGGTGGGAAGTCCCCAGGGAGCCCCAACAGTGCGGGCACTACCGATGGCGCTGTCCGGGTTCGCGTCCCGTGCGGTAAGCGGCCAGGGCGTGACCGCGTGGTCAGCCGACTTCAGGTGCCGCGCCAGGCGGAGCAGGCTCCTCCGTGGTGACACACCGGATGTGGCCCACCCACGAATCCGGCGTCAGGGAGGACCATTCGACGTCGATCTCAACGCCGTGGAGTATGCGGGTGTGGTCCGCAAGTTGCGTGAAGATCGCCGTCTGTACGTCCTCAAGGGCCGCGCTGGCGGGCATCGGGACCTTGCCACATCCGCCACCCGCGTTATCAGCGATGAACGTGTAGGGCCACACATCGTGCCCAGTCAGCAGGATGATCTCCCTCGGTATGCCGAAGGAAGGTCGCTTCGTCTTCGTCTTGGGTCGTCTCGCCACGGTGCCATCCAACCTGACGGACCGAGGGGTCAAGCACCCGGCATACACACCCCTTCCAATAGCTGAGGACCGTCCCACTGACACAACCCTGCGCGTCACTGACATCCACTCTGCGCACGACAGCACCGTCGTCGGGGGCGGGCCGCCTGTGGTGGGATGGCCCGATGATCGCCACAGTGCTCTGGGAGCGCGAACTGCACCAGCGGGGCGGCGCTTCCGTTTTCGTCGTGGGGCCGGACTGTGTCGTCCTGCACGAGCGGCACACCCGGCTGGTCTGCCTGGAGCGCGCCGACGGCGCGGTGCGCTGGGACGTCCCGCTCGGTACCTGGCCGCGCGGGATCGTCCTAGCGGGGGACTGCGTGTTGGTGTTGCCACAAGCACCGAACCTGCTGTCCTGCATCGATCTGCGGACGGGTGCGTCGCTGTGGAGTGCCCCGACGCCGAGGTGGACTGGGAATCTCGCGGTCCACTCGGACACCGTGGTGATAGGCGGTTGGCGCGGCTACACCCCGATGAGTGGCCTGGACCTCGCCGACGGAAGCGTCCGGTGGACGACATCGTCGCCGGTGACGTCCGTACGGACCCTCGCGTGGGCTGGCGGGGTGCTGACCGGCAGCGGGTATGAGGCGGTTCTCCTCGATCCGGCCGACGGGAGCGACCTGGCGCGGTGGCGGTTGCCGGACCCGCTCGCGGGACCCGACGCGAAGGCGTTCGTCCCGCTGGATACGGAGCGGGTGGTGGCGGTCTGCGAGGCCTCGTCACTGCTGACCTTCGGGATCGGTGCGGACGAGCCCGCCCGGCTCGGATCCTATGATCCGTTCGGGGCGGTCGGGTACGTCCACGGGTCGGTCTGGATGCTGCGGTCAGGCAGGGGGTTCCTCGCGGTGGATCCCGCCGACGGGACGTCGCGGTGGTCGGTCGAGGCGGATCGGCGGGTGGTGGTCGACCCGCTGCCGTACGCCGACGGCCTCCTGGTGGGGGACGCCAACGGCGGCATGCGGCAGTTGGGGCCCGACGGCAAGACCGTGGAGGGGTGTTCCCTGCCGGGTCGGCGCCTGGACGCGCTGGCCGCCGCCGGCGACGGCGGCCTGTTCTTCGCGGCGAAGGGCACCTTCGGCTCCTTCACCCTCGCTCCAAAAGCCGGGCGGCCGACCACACCCGCAGCACTGTCCGAGACGCCAGGGCCCAACGTCGCTGACATCGCACGTGTCGCTGAACACTGACACTCTCGTGTCGTCCCACACCGCAACCCCCGCACCCGCCCCGGGGCGGCCACCCCGCAACACCGGCAACCCCACACCAACACCGACAACCACACACCACAACCCCAGGCACGCCCCCGACCCCGGGCACGGCCCCGACCCGACACCACCCACACCACCCCCAACCCCGGCCACCACCCCACACCCCCCAACCACCCCCCACACCCGGCCACAAAGAAGCGACGACCACCCCGGTCTGAAGCTCCGCCACCGACGCGTTTCAACCGCGGCCTGACGACCACCCAGGGCGCCCTTCACGACCGCGGCGCGGTGTTGCGGGAGAGCGTGAGAGGGCGGCTGCCCTCTCGCCCCAGAGCCGCAGCCTCCGGTGGCGCTGCCAGCAACAACTCCACCCGCGAGCGCAGAGAGGCGACTCAGGGCCTGAAAACGAATTGCCGCTCCTCATGTCTTGGTTCTCGCTACCGTGGCGTGATGACGATGCCCTCTTCAACGGGCCTCCTGAGGCTCGCCTTCGACGGCTTCCATCAAGCCCGAGCCCGGCTGGGCGAGTGCCTGTCCGCCCATGGCGCCAGCACGGACGCGGTCGCGATCCCCGCCGCTGAGACCATCTACTGGGCGTGCGTTCTCGATGAGCAGCTCACCTCCGACGGCGGCTACAGGACCGTCCGCAGGAGGGCGATAGGGGACGCGATGCGCGGGGCCCGGTGGGTACGCAACCGCGCGACCCACGCGCTGGCCCTCACGGTCGAGCAGACCGGCGGCCTCAGCCTCCCGCTTCAGGTGTCAATCACCATCGAACCGGTAGTCGGGCGCTGGCTTCGAGCCGACCGGCTGCCTCCCGAGCCTCCGAAATATGTCGACGCCGCCGGCCGGACGGCCTACGACAAGACCTTCGCCGACCGGCCCGCGAGCGACCCCGTCGAAGACATCGCGCAGTGGTTCGCGAACGAGCACGGCCGACCCGGCTCACGCCTGCGCGCGATGTAGCAGCGGGCCTTGCCCAACCGCTTCCGTTGGGCCCCCTGCCCGCGCGATGTCTCCCCCGTTTCCGTTGGCCGGAGTCCGGCAATCAAGGCCGGAGGTCCAAGGCAGCCGCATAGGATCCGGTGCGCGGGACGATGTCCTGGAATACGCCATGCCGCTGCTCCCGCATGCGGAGCCTGTGGCAGCGTCGCCAGCAGCAGGCGCAGCGCCTCGCCGATCGGGCACGTCCACCACGTCGCCAAACCGTAGGTCAAGAATGAACCACGCTCGTTCAGTGGGCAGATCCGGTGCCGGCCAGACCGCCTGAGTCACAAGGTGACGGGTACGGGAAGGCCGAGGGCGACGGCCGCCCGGCGGCACCCGGCGCGGACTGCGGTCAGTTCGGCGCGGACGTCCGCCCCCGCCCGCTCGCCGGCAGCCGATGCCCTGGCGGCGGACGTGTGCAGCTCCGCCCGTGCGGTCGCGCCGTCGCGGGGAAGGCCGGTGAGCTCGGCGGCGTTGGCCACTGCGCCGACCAGCCGCGCCACCTCGGCCGGACCGCACACGGACCGGGGTACATGGACACCGAGCAGGCGGGGTGCCCACCCTGCGAGGGAACCCCGGATCTGCTCGCACAGCCCGTCGATGTCCGTGTGCGGGCCGTCGGGCGCGATACCCGCGCTCATCTCCTCATGGTCCCCGCCGCCACCGACAACGCCCCTGGAGGCGCCGCTCACGGTCGTGCCGCAGCGCCGACGCGCTCACTGCGCCTCCTGCCAGCACAGCGCGGCCAGCGAGAACTTGACCAGGCTCCGTGCGTGACGAAGGGTTGGACCCGGTCGGCCCCGAGGGGGTCTCGCCCCCACCACCACCGCCGTCTCGAGGGAAGAGTCCTTCCATGCCTGCGCACAGCAAGTCCGTGTTCGTCCGCCCTGACCCACGCCGCCTCCTGGTGCTTGCTGCCCCCGCAGTTCTCGTGGCGCTCAACCAAGGTCTCACCAGCAACGGCCAGGTGCTGCCGAGGCCGGTCTACCTTGCCCTCGGGGCCGCGTTCGCTGTCTGCGCCTTCGCCCTGCGCTGGCTCCTCGCCGTCTCAATAGCGGACGGATACATCGCCGTGTCCCGGGGCCTCACGCCACACCGGCTAGCGCTGGCCGACCTCGACAGCGTCGAGGTGGAGGAGGCGGGGCGCCTCGGGTATGTGATCCGCTGCCGTCAGGCCGGCGAACCGGAGCTCAAGGTTCCGCTGACGATGATGCGGCAGAGTGACCAACGGCTGGTGATCGAGGCCGTCCACGCCGCGGTCCGGCCGGGTGTTCTACGGGGCGGCGCTGCCCTGCGGGCCTTCACCACGACGCCTTAAAGGGCGTTTAGTCCCGCCTTGACCGTTTGGGATGTCGTCAGTCGAGGGAGCCGTGATGCCGTGAGTCAAGCTGCGTCAGTGGGACTGGCTGCGCTTGTACAGGGCGGTGCTCGCTCGGAATCGGAGGCGGCTGCACCGGTCCTTCTCATCGGGTGACGCGTCTTCTGGACAACAGCAGTGGCGTGCGAGCCACCCGAGGTCCTCTGCTGCGAGCCAGAGTGCTATGCGGCCTTGCGCGGCTTCTTCCTGCGGATTCGTGGGGATGGCATCGGTCATGTGCGCGACCCTATAAGAGCCCGGAACCCGGCCCCACAAGGCCAGGCGGGGCTCGGGACCGTGCAGGCGGCGTCGTCCGTCGGATGCGGGCCACCACCTTGCGCCAGACGGCTGCGAGCGGTGGGCTCGAAACCCGCTACGCCGGTGCTGGCGGGCAGGGAAGGCATCGACACTGCCGCGCCCGAGGAGCGTGCGCACCAGGGCTAACGGGTCCGACCGCCTCGAGCAGGGCATCAAGACGCTCTGGCGCGGGAAGAGCCTGCGGGTCCTCTCGGCTGTCGGACGGACCTGGGGCAGGAGGGTGTCGAGTCGGGAGAGCGCCTCACGCAAGCCGTCGACCGTGTGGCGGGCGTCCTGCCACCTGCCCTCCTGCAGCGCGGCCGCGAGGGCGCCCACTTCGCACAGAGCCCCACCCGCCGCGGCGGCCAGCTGCCACTCCGGCCCCGTCGCGGTCGTCATGGCGGTCGCACGGCTGTCCATCACAAGACTCCCCTCCCGTCGACGTGTTCAACGAACCGCCGCCGAAAGGGCCCTGTCCAGTTCCGTACACGCCTGCGGGACGGGCGGGACAGTCACGGAGAGTCTTGCGGGCAGGCGTCGATGCGCGGTGCCGCCGAGGCCGGGCGTGGCTGGTGTCGTACGGAGCGGGCAGAGGCCACGGGCGGGGCTGGCGTGGATGCTGCCGACCGGGCGGTACCGGCGACGTGTGACGGCAGCCGGGCCTGCCCGCGGTCGACAGCGCCACGGGGGCCGGGAGCAGTCCGTCCGAAGGGGCGGCTCCACAGCAGTCGCCATTGCACCCCGTATCCGTGTGCGGCCGGGTGTTGCCACGCTGGGGCGAGGGGTGAGCGCCACCCGGACAGAGTGCTCTCCCCCGGCCGGCCGGGGCGATGGCCCCGCCGATGGCCGAGGTCCCCGTACCCGTCTGCGGAGCGTCGCCGGTCGGCCGCCCTCGTGCACGGACGCGACGGGCGCCGGCCCGGTCAGCCTGCGGGGGCGTCGATGTCCTCACACGCGCTGGAGGCGGCCGTCTCGGGCGGAGTGGCGATCGCCTCCTGCCAGTGCTCCCGCTCCCCCACAAGGCCCCGCTCGGCCGGCTCGGCGTACCAGGCCCACGCCTCGGTGCCCGCGGCGCCCGTGGTCGATCCGGACTGGACCGCGATCACGTATCGGCGGCCGGGCTCCAGGACCGCGTAGCGGTCCGGATCCTCCGTCGCGTACCGGCCCGGGCTGCCGCCGTTCTTCACCCCTTGCGTGACCTCAAGGACGTCGCCGAACTCTCCCTTGAAGGCTTCCAGGGTCTTCACCCGGGTCGTCAGGTAGGCGCTGCCGCCGTCCTCCCGGTAGCGGGTGTTCTCGACCGCCTCCACGACGGCCACCGCCCGGGACCGTGCGGCGACGACGTCGTCCCGGCCGAGGTCGGGTCCGCACACCGCATGCGTGGTCCCGGTCTCCGGGGCGGTGGTGAACCAGGCCGCGCCCGCTGCGGCGACAGCCGCGACGAGGCAGCCGCCGACCCACATCTTCACGCCCATGATCATCCCCACAGCTTCTTGACGTTGGCCTTGTCGACGTCGGTGGGGGCGTCGGGATACTGGGCGACATCCGGCCACATCACCGACGAAACGGCATTCTTGCCGCTGCCCGACTTGTGACACAGACCGAGCGCGTGCCCGAGCTCGTGCGCCGCCACCAT

Protein sequences of DBSCAN-SWA_1

>NZ_CP018870|7442:79194|54395_54725_+|WP_075971903.1|DBSCAN-SWA
MTLTDLRDGFRDDDQRQCVQAVVHSRLADDREPQECRYLMRFWWQLSMPYQEVSLEELRLNVGRQKLDALMELISAIRSSHDEIDAWLADAEKTFPVIQDRGFSSDRSD
>NZ_CP018870|7442:79194|71766_72237_-|WP_075969513.1|DBSCAN-SWA
MTTEEYLSTIDSLAVQPFPEVTYVDASGGGGPEHHVRELQVSRDFWDDDDGRAWVEAEAELQARLDDLAARLTDRWGSAFVADLGPYLSASYEGEPVPEPLDYLSQQAVSMQVWPLPDNGRWLALALGQADKELPLILFAAVGRASALGLNTSGRS
>NZ_CP018870|7442:79194|12489_12810_-|WP_075969476.1|DBSCAN-SWA
MQQLGEHHGTDTVAQHLNRLTTATSWQEATGSALVGRLVDATLTSLTTPPGAPAPSRPRVSAAAARSRSTTTPTAAAAPGRPAPAEAAVPTHRQQAAPVRGAGRRR
>NZ_CP018870|7442:79194|43040_43478_-|WP_079273058.1|DBSCAN-SWA
MLAEAVVYPEIGPGCTLTGGVWWLYYDEREVTPAGALDIDHMVPLVEAWDSGAAAWTAARREAYANDQGQLASLVAVTARSNRSKADQDPAQWLPPAPDALCRYGAEWTATKLRWGLAADEAERERLLDIAAGCSGTDVEFTPAP
>NZ_CP018870|7442:79194|75367_75883_+|WP_075969516.1|DBSCAN-SWA
MTMPSSTGLLRLAFDGFHQARARLGECLSAHGASTDAVAIPAAETIYWACVLDEQLTSDGGYRTVRRRAIGDAMRGARWVRNRATHALALTVEQTGGLSLPLQVSITIEPVVGRWLRADRLPPEPPKYVDAAGRTAYDKTFADRPASDPVEDIAQWFANEHGRPGSRLRAM
>NZ_CP018870|7442:79194|19024_22894_-|WP_079273398.1|DBSCAN-SWA
MDYLEIAETHLAGGVLKGTAGLANFVRAVTPFDPYNLTHPAEYRTNLNSTVAGLLVAVNDPIGTGKQMLDDFMKDPTEGVGKFLPELAGTKGLGAGKKAGTAAKHLDDLDGPGGKETDGPGRKETDGKGPHHGERPDPDKASEGTDPVDLATGRMYLPQTDVVLPGTFPFAFTRRAESGYRAGRWFGPTWSSTIDQHLEIDAKGVVLVSEDGLLVGYPHPAPGVPVLPVSASAPRHPLARTPDGDWTLTDPLTGAVRRFVPPADGAENGIAPIAQFEDPNGNHVVFEYDEHGTPLGLTHSGGYRLHFETEGGRITALHLSGGGRVLAYGYTDGNLTEVTNSSGLPLRFAYDDRARITSWTDTNERRYEYAYDDLDRCVAEAGEAGHIALTFRYDDVDPQTRHRVTRVTTAAGHTRQYLIDDRYRVVAETDPLGAVTRYQYDSGGRRTALTDPLGHTTRSTFDDTGRMVSYVRPDGREARAEYNDLGRPVKVVAVDGSVVHQTYDERGNRTAVSRPDGTVTHFGYDESGHLTTVTDPRGAVTRIRTDRAGLPLAVTDRLGATTTYERDAFGRVTAVTDPLGAVTRMEWTVEGKPLHRTDPDGRRRSWTYDGEGNCLTRTDGPDGGGVHFEYTHFDLLAARTDADGTRHAYTYDAELRLTGVRNPQGMTWEYTYDPAGRLIRETDFDGRVLDYAYDPAGRLVTRTDALGQRITYERDALGRTVRKDAGGTVTTYEYDVFDRLAVAVCGDSVLTRLRDRAGRILQETVDGRTLTYTYDAMGRRTGRTTPTGAVAAWAYDAAGRYDALTTSGRRIGFTHDAAGQELSRTYGDAVALDQAWDETGRLVEQRLTGAGQGVVQRRGYTYRSDGVLTGVDDLLAGPRSFDLDPRGRVTAVHAGNWTERYAYDDVGNQTSAYWPGAHPGGGEATGPRTYEGTRLIGAGRVRHEYDVLGRVVLRQKARLSRKPDTWRYEWDAEDRITAVTTPDGTRWRYTYDPLGRRTAKERMTPDGLEVAERTVFTWDGTVLCEQRTAAAAQEAGGIAVTWDHRGLQPLAQTERILGASQEVVDERFYAIVTDLVGAPAELVDERGGLAWRSRSTLWGSTAWNRDATAYTPLRFPGQYFDAESGLHHNYFRTYDPETARYLSPDPLGLAAAPNPVAYVANPHGWCDPFGLAPYSDSTRAAQGVDHQLNEAESGKDNHYLQGIGKDEVKLEKYLRGHLQSPANYVDSDTGARIIIDKTLDPSRPVAIIRQDHMIHAYHIEPEDLSNYITPRDGKDTAKWRTPKGDEVNE
>NZ_CP018870|7442:79194|36797_37001_-|WP_075969493.1|DBSCAN-SWA
MAHRSDRTGDAKKDIVPRVGGELRVYRVVGAGDVTKDGHPDLLVQHSNKLYLYASIAMRRAAVGTRS
>NZ_CP018870|7442:79194|48193_48670_+|WP_159393487.1|DBSCAN-SWA
MAKVCWSAERSTNVEYASFRVGAFSLLDDTVMEQLPPAAGGLAVGEYAVGIGSLVHTHFDVDVLVEVWDEAPPVLAGQEPLGEASIAVRSGIFAVYDFWGAPRGEPIPLGGPARYALRVYRFPMKRPGAVGGAEGLETYAVHVWQAAGEAGGPPVLLE
>NZ_CP018870|7442:79194|35820_36381_-|WP_159393485.1|DBSCAN-SWA
MDAAVREAAVARFLREYPLMEQAACDHPALLGCADVDWSQIPGCPAGVPVLLRGLLDEVAGPAALTVLENVLMNSVFHVSAVMPAVLPFLIRLAAVPDIAVRSGLVDFLVVAAELSSSVDADDERQVLLFGKDSDHPEREWCRAAFAAHASALRALLEDGTLPDGLISADDRECLLRAVEPQRRPS
>NZ_CP018870|7442:79194|67532_67844_-|WP_079273060.1|DBSCAN-SWA
MNFDENEPQSVREERFTAERAERREARKAASLDSRGAHLGAVIVTVALVLLSWYGELIALGIVSGVFVLWFAAALAWAYVDGDHGRHALQRAYNVTFGWGDGF
>NZ_CP018870|7442:79194|42495_42783_+|WP_045322888.1|DBSCAN-SWA
MWPNAVADALSRFEWAFKQPGRYLNASEACSPGIEVEDARDDLERAMLHLPPGAQRDLGRLITRIDEEFERRTLPEPNYTEWAMHGWWWTRMRER
>NZ_CP018870|7442:79194|35013_35307_+|WP_075969491.1|DBSCAN-SWA
MINLHVRGESGTIEARAKHGVLWGPELAGLDQAVFPMLGHLLPYGDTVFNHRQVSTLLEEVPRLPAGVLTDEFARELIELGQVVLAGQGLYLWFLGD
>NZ_CP018870|7442:79194|72472_73051_+|WP_075969514.1|DBSCAN-SWA
MQNRPTLVVVSGPPATGKTTLARALAQQLGCPAIIRDEIKQGMVMSTPNHQPAGDDPLNIPTLDVFFKAITVLLQAGVTLVAEAAFQDRLWRPGLEPLLDLADLRIIRCVTPTSTITERITERARTDSHRAAHGDQALLADMEAGVYDPEQFKAISLDVPTLVVDTSDGYMPETAEIQAFLRTPPPSPNPRR
>NZ_CP018870|7442:79194|23679_24237_-|WP_075969484.1|DBSCAN-SWA
MAGDADLEVSPAAVKNIQDGLRRAVAELRESGDAAGASMGAGFSDLSMTGMEAGHAGLATDFEDFCERWEWGVRSLVQNASALAGNLGIAAGTVWEEEHYMQGAFKVVANAAYGNPHASEDEIEQKSWDDIWRADVYKPDYSDESFEKSDADIKQTWSDTGDKLTSSGKIGSLKDLLDQAGGGGN
>NZ_CP018870|7442:79194|56731_57505_+|WP_075969508.1|DBSCAN-SWA
MSELTSTRIRTTATRLGLPHLAEALSHYIQRADEAKMGYLDLLDLVLSEELAVRDDRRFRNGLRLSKLPHHKTIEDYDFSFQPELDPRKVKDLATLSFVEDKANVALLGPPGVGKTHIAVALAVAACRAGYSIYFTSLDDMVRHLKAAEDQGRLMSKLTSYLRPAVLVVDEVGYQPLERTEANLVFQVISKRYEKGSIILTSNKTFGEWGQVFGDEVLATAILDRLLHHCEVVSINGNSYRLKNRLAAIERDRNDAA
>NZ_CP018870|7442:79194|40233_41997_+|WP_079273057.1|DBSCAN-SWA
MSAREERPALRSQTTSLHDYALFRRGIEPDGRAPAYGYPVPGDRLRSALRFREATRLLAQLLGPAVDDPDPVGAAATLDRRLPQLGVRPDLVHHPLARLPLTNESAALALGRQLVRTASDPTALGAGIHLVGRLGGSEDVPQLTTLALLQGFLRPVVTALSALRCDTEVLIRLMDLLDPQDHGVVIDALASREDPAARRWLLNLPVGPGTTSSRAHHIALAVRLADLLQDESVDASVLAQGGRLLTRMALATGSPAEVLGYGPAIAVYEALVRRADRLPPTLDHHAILLSLALDLSSGASVLLDWPPGLREELLERLERLLGTPAWAAVPDGGHRHRDRYRADWIRRMRREPLDRTTPNGLRIHVVEHDPEIGGHVEARILLDGRPLVPRLFPAGHSPSPEHVLGQDLLRATPEERTVTLSTAECDEGCCGTLSVTVRRDGAHVVWHGPRQNGIGPQLPEHRFDAAAYHAEVDRARADDTWCRPARSTARLIQAGLGERPGLLARWGILQSWCRPAGPYEDTVEVDFWYGPGAGRDPVGDEAGQWVRLTWRLPDDGRRPGVRAAAALERIAATDPKTYSRVTGGNAE
>NZ_CP018870|7442:79194|37114_37378_-|WP_045322884.1|DBSCAN-SWA
MEALEPDELQRLVLAAVDPYIDRDILAREIAREEQQRRALRARRSPATAHRGNGQGGKVIAYEGATAPWIQLGQSVTPAAPGDMTGD
>NZ_CP018870|7442:79194|62707_64537_-|WP_030035897.1|DBSCAN-SWA
MYLDSYSARGFRSLAQVTDIPVSGPTVLAGRNDGGKSAVLTALAFLLGTHRLTDEDRTYVQDEEGSKGRRCAETWVEGQFRLDAEEQAHSGLGECVRIRRRSLLGEATCLEYFGSQPADPQLRDLGRLLKPALTALVAEYGLSPAGNLKEDLLAELRAHARTLPQDEGWQPLPKTLEERLPQLLSFGGKDESPDDAVRTALSSSYKTHLEDETLQGRVREIEGEITQRLEKEADSLCLHIRQHCAEYVSVNVKPLVSFKGGFQGAPLHVSRADGEPVDLTRAGQGSTRRIALAVWEWTSNLLENAELAASAEQGNTQPTQTIVVYDEPDTHLDYRHQRTVMDIIRKQCALPHVSVMVATHSMNLIDGVDIADVVHLSLGPGGRTVVERLDDDQHDGIDFHLGQIAASLGLRNSVLLHERCFLAVEGDTEQKSLPLLFRLAQNMSLQAAGIALWGCENNEGALHLARYLVKHQRTVMLMVDADSRTNKLFKDERLRRAGLDLEKHVSYVGEADGYNELEELFSDEQWATAANTHWPRPAPQTWQAHDFTAHRDGKKFSARILDMIQNQAGNNSPNGKPAMVYGLASTLTTAQDVPRQLRDIFTHLQELAH
>NZ_CP018870|7442:79194|76757_77222_+|WP_075969518.1|DBSCAN-SWA
MPAHSKSVFVRPDPRRLLVLAAPAVLVALNQGLTSNGQVLPRPVYLALGAAFAVCAFALRWLLAVSIADGYIAVSRGLTPHRLALADLDSVEVEEAGRLGYVIRCRQAGEPELKVPLTMMRQSDQRLVIEAVHAAVRPGVLRGGAALRAFTTTP
>NZ_CP018870|7442:79194|57516_57693_-|WP_107484881.1|DBSCAN-SWA
MESLGNLFMAAVWGIPLVTLLGGAVAVAAVTRWRRREIRALKRAEEEQGGPALEVSGR
>NZ_CP018870|7442:79194|25400_25631_+|WP_079273053.1|DBSCAN-SWA
MAAGGKRLSVHLADQDDKILVMALNHQTREQDAAGAVPAGVAVLRTVDACGAHTDHDGHAWWALLDARPAPKKRLA
>NZ_CP018870|7442:79194|24236_24650_-|WP_075971905.1|DBSCAN-SWA
MGLAEEISAVRSVSGHSGRLLGEFRRAALLVPLSEGDGGGLMSGWQGGVRWIYAFTDEEALARFAVARGADAGAREWEYLSILGARLVDAVIPTVEGPTGVAVDVADEDGSMLFPPVVGIVPDAYAVDAGPDRAEAV
>NZ_CP018870|7442:79194|18273_19032_-|WP_075969482.1|DBSCAN-SWA
MSSRSGIPRDPAPGWPGYHAEPSYDPGQSRVFPAPLPAELRALGNDVRAADWPVRLAFRNSRTELLDTLCRWQTLRALAYVHLLAARTGDERLPADLRVVPDPEAVGEPGLPALLARLEHAAAGLPADLLDAVVCDSGGLLADNRFAASVLAAGLTADSRPGDPDKAVSRAVVLTSYWYEVPGLRGALALAWSANLFVRSWLGWSQRFVYGDPAGGLGITSDPRPPRPAASALPKWAEPLLDRIEQGPGAAS
>NZ_CP018870|7442:79194|37464_37725_+|WP_045322885.1|DBSCAN-SWA
MSSEDLGAVWVLQGFSKVDDFLRTEFPIGREQIMQLREVITPDADDPWMFDGYDVPIELWPAVDAILQCGPPDPGLDYQTGCYAAD
>NZ_CP018870|7442:79194|49342_49876_-|WP_075969503.1|DBSCAN-SWA
MSNALARLLEIAPAPSQPRDKAWSEVERTLAVELPNDYKELISVYGGSNWDDYLYILEPGCPNRHYDLLKWAEYQFRDLQDLWTFEKRPAELETEGSVVVPWATTDNGECLYWLVLPGVEPNEWTVMVNEARGPRWEHYSVSCTQFLASALTGELKSNILSSSFPLASHKFRRLSPA
>NZ_CP018870|7442:79194|8197_10315_+|WP_075969473.1|integrase,transposase|DBSCAN-SWA
MSARRTARPAVAVGAHVRFRGVKWQVVALSGQMVHLVGPDGGGEAVLAGYLFADPGFSVIGAEVPQAAPQWGLFETAPAAAREKALAWQRHVREVECGLADGPGSGGVVREQYDPARHTLAEREQAKAEELTALGFGRVSRTTVQRMRLAYRKQGLWGLLDHRTTRASSSTGRSDERVVAAVREALRRRRGRSRGTINGLFPLIHQILQDRHGPGAVPVPSQATLYRLVTSLARPGELPSGPVRQVPASVEGRAFTPATALRPGEQVQIDTTRLDVLALFDDGRLARPELTIAVDVATRAILAAVLCPSATKSVDAALLLAEMAVPHPARPTWPDILRMDHARALPYQQLATLDERLAGAAARPVVLPETIVVDRGKVFVSAAFTAACETLGISVQPAPPRAPTAKGIVERTFGSINALFCQHLPGYTGSDVTRRGPEAEKDACFSVAQLQDLLDEWLVHYHHRPHEGLRHPMMPRKALTPNEMWGALVAVAGYVPVPLTGRDYLELLPVRWQAITPAGITIRHRTYDADLLAPHRGQASPVAGRGGKWEIHYNPHDVRQIWIRLPDGELTEIPWIHRDHVHRPFDEHTWQHIRTQATDCNHGDAEQHEARLADALDQLMRRVHSGHATKTEQTLLARTAHVPLPTARNGAHGTEAPADSPEQRDDDTIDDLDDLDGLDDLPDDVSPAPATGLGLYNAHEEADKW
>NZ_CP018870|7442:79194|11727_11994_-|WP_075969474.1|DBSCAN-SWA
MRFFSVKGREYVALTVLGSDDFDALEVVEMTAAGRGALLLEFRMDEETATLVHLGAEVGIPLLRASLEIFRTDFLEPRRAAGLPLRPW
>NZ_CP018870|7442:79194|38568_39822_+|WP_079273056.1|DBSCAN-SWA
MDMGERWAEYDGLRGRVPSWHPVGVVVRADGPVVRRHYGTHGTVEHAPLKPGTDIAGLVRHQQEGFAERGEPVEWKVYGHDAPDLSRALTAAGFTPGWERSVLIAEELPGEPDVLVEPRNDIRSLYAVREQAERAWGIAVGSPGPHAVPYAEMIADGASEDGDVYIDVLLQHREVTAVGWVYADLTRPFKVVGGLSSDDAEFVQGCTAHWRTQSSRPLLAEAGGLLRERLLKAGFMEAATVRSYHWRPTGTPEITRPAQFLDWLHDDGPLRDRFQTEFDFKPSTTSLPAISAPVPSAVWHLHAHHRPVPDLPEQIDAIVQRGLLTATKPGEFVYWLDWQHDGYRYDPRRTDLPGRPPRPGKGTYPNGDYYLHLTDDLRLGTFGHPWEQTLTVWGPPLLAAVEAELTELLGEPVRRRG
>NZ_CP018870|7442:79194|25926_26481_-|WP_075969486.1|DBSCAN-SWA
MGEIEDAILRADQEAFTKDPPKTLKGQINFLLKQLKTTRAVAAELGVSQRSVERYRKGDRKTPPQPVATRIEAAVRARWQPVVRGRRRKEAATSTGITVETRARFGYTAPVGTTDDGRVRRLTVHLPPAYAQRLFDARARGADDRDLRGIVAEGLQEIYFKDGGTRADELRVEFTDIDYFDVSF
>NZ_CP018870|7442:79194|45927_46467_+|WP_075969499.1|DBSCAN-SWA
MADDSTSTFQAGQTGLIVRIPEAEPSVRGWREQLDPSAQAGVPAHVTVLFPFLDESRIDALVYSALADVLASHPAFDLRFERCGRLPEVLYLVPEPDTQLRQLTEAIADRWPEAPPYGGRFAEIVPHLTIAQGQEDAVLEEIEADLADKLPFTSHVASVELMVHDGVKWQERASFALGE
>NZ_CP018870|7442:79194|10398_11367_+|WP_075971904.1|DBSCAN-SWA
MTTWQGWQRFATTDPVAPPQPGDPPRSTEERLAYHSSFVTIRTPAIHTLTTQVRTLMILGRHQQNTARPSLIVTGPAAAGKTTALLNVGRTCHLAHTRKNPAPPGSAHTAVPVAYVLVPPGATAKTLVTEFARYLGIPVTARMTQTQITDAVCHTYTQAGVQLVMIDEIHRLNPRTTTGAQTADLLKDLSERLPATFVYAGINVTDTPLFSGTRGAQLAGRATLVDCGPLPARHGTRQPFRDAITDIENNLDLQQHKAGTLPAHAPYLHQRTAGRIGSLTRLIRQAAITAICDGTERITKTALDAVRLDHLAETHHRPHRRR
>NZ_CP018870|7442:79194|55316_56735_+|WP_107484686.1|transposase|DBSCAN-SWA
MVLDPHRWLELRRFRPLYASGAMSLREIAKETGLNRRTVSKYLKNPASAGLPRRESDGRQPRRVVDEIAPLIDAMLRSEVLLKGSVIHERLVADYGVAINYQRVKIYLQEARPRIAEELGISPGELAGLHRRFEVVPGAQAQVDWGDEGRVLAHVGIPKVYSFHMTLSYSRDPFCCFTTSQDLATFFDCHRQAFAHFAGVPMSIVYDRTKTVVRRHVAPGEAVPLHPEAVAFAGHYDYDIDVLAAYRPQGKGRVERQVNIVRDHVLAGRAFSSLEEMNAAFAAWVPLRRAKVHSTHGEVIGHRAARDHTALRPLPGTPYVVAQRHLRHVGKDCLVAFDANLYSVPARKVRPRQLVEVRATKSQVSLHSTVPDAGGLTLLAVHARAVGRGAHVVDETHWDGLPTGAGRRVTTGDALPSPRRGRPTGSQTGPLQALLSRSAAAHVEVGRRPLSVYDELTGTRPFNPPAPTKDAR
>NZ_CP018870|7442:79194|53798_54182_-|WP_075969506.1|DBSCAN-SWA
MTHANDSDDPLQLLMGLEVSDVSFVRDYVELHFDGPILRALSDPSGVYGGREWSFPAPGSLELMRCYIGETVDGYELDPDRILALDFGEHRFVIPLDSDSSGGPEAAHMVDVDESGRASVLGGMWIW
>NZ_CP018870|7442:79194|51643_52234_-|WP_159393488.1|DBSCAN-SWA
MTAPTPAPGHPQRPDDVPASAASEAGQPFTPQLANGPGKPDSQLNAKQKTVLGCGGMIALFLIATMFAAAVSPSDAKPAEAKPAPTVTVTVTATVTVTAPPPVVAKAPEPMQEAAPQTAQVPDMTGKSGDLLVEALKTAGFADGYKATSFHDVSGQGRTVLLLTNWKICDQDPKNKAVPITEKVSVGVVKFGEDCP
>NZ_CP018870|7442:79194|50219_51317_-|WP_075969504.1|DBSCAN-SWA
MAYGQPPYPYTPPPAPIRPWWQTSGVRLGFIGAAAVIMAIAQGLGILLMFASIAMIWISTGGLRHPWQVWQRIAATVGTLMLCLIVAGIAHPVKKKDDAKAAATPTTAATSKASETPAPAAVPQLSDYTGKALTEARKGAEAAGYTVGNRDASSEARGVVLAGNWTVCFQKVSDLAGGKKGVDFSVVKEGEPCPKEDGGALPWPVMPNVVGATYNKAMADLKAAGVPLERVSLEDVYLDTDTPTAEQAAKDGEEWHVCFQDPGKDGKVTSTTTVRLDLGRWSEASLVKSCPATKGTTYQIPANDPDYERPGTSTGHDDSSSSSGSTGGGAKTVHPGAFCSPGGAVGTANGKTYTCKGPGQNRWRQ
>NZ_CP018870|7442:79194|65474_65786_-|WP_079273395.1|transposase|DBSCAN-SWA
MGMKHYPAEFKADAVALYQSRPGATIKSVAADLGVNTETLRNWIRAADGRRSGAHSTPPAAAQSGGDAVQAELAAARKRIRELEEERDILRKAARYFAGETRW
>NZ_CP018870|7442:79194|61237_62437_-|WP_075969510.1|DBSCAN-SWA
MRFLHTSDWHLGRRFHTEDLIPAQRAFLDHLVDTARTEDVDAILVAGDIYDRAIPSLDAVRLFNRALHQLADLGVPIIMISGNHDSAHRLGVGSGLLARAGIHLRTDPDTCDIPVLFDDADGPVAMYGIPYLEPSMVRDRLEAEAVSHRAVLTAALDRIHADLTNHQPAGTRSVVLAHAFVTSGTGQPEERDESQESTSEREIAVGGVAHVGSDVFDGIDYVALGHLHGPQRVTDRIHYSGSPLAYSFSEARHTKSITLVDLTPNAVPALTRQPCPVPLRLERVSGFMEDLLTNPDHEPLKDAWLEVTLTDTALPFEAMARLRRRFPHTASLRHKPAFIPSQATNTPTYSQRIRGRGDLDIASDFISSMRGTDPTPDEHALLQQAVEASRLNEQQKESV
>NZ_CP018870|7442:79194|58227_61236_-|WP_075969509.1|DBSCAN-SWA
MRLHTLRLQAFGPFASTHTIDFDALSADGLFLLHGDTGAGKSTIFAAICFALYGKPPGDRDLLLRSHHAPAGLLTEVTLEVTLAGRRLRIDRIPAQMRPKRSGEGETSQKAETRLSEWAVDADGQGRWEPSSKSHQEAAVEVTDLLGMSREQFCQVVLLPQNEFTKFLHADAHGRRELLGKLFRTGRFSFIERWLNDHSRTTEKNRDATRADVLRLAERIHQAAGPDLETEYTAPTPDDPNTLTEPARAWAQDLLRVSHTDHARTLQAATTAKENLARQQTFEAAARELHQQQTTYTSARQQLDLLQEQTPHQDTLIQRRDQARRAQQAAPLLHAADTAAHDHTRAQSVERSARERLLPEHKDLDASRLETAEHRLRAEAAILTTLIPEEDTVRRLTTELERTDAERQDFATQQRTAQDWLEAEPARRGALEARREAARQAEEESRRHQTALDGLKTRLEAARRRDTHLAKVTKAEQQLADAEAVTGQTGQDYLTIRRRRTEGMAAELAATLTDGTPCPVCGSCTHPAPAAAQDGQPTRQDEQDAEALHEQAKTTQKAAAAVLHGLREQAATAAGEAGDTPLTDLQTQHTTLTTELTDVLDRAADQGTVQEELLALDGEHTAQTQQHSTATAGLSARNAHYDTLTQQLTELTAKLTAARGTYPTVAAHADDLTRTAHRLKETAEASRSLAAAVQTLAHRTDQATLAAKDQGFDTLALAQQALLNDEDLRAIEEEITQWREACAAHTAVLDNPALQQAAAQPSANLDAATAARATADDQHAEAAAAASAAHTRSQALTALAANLGTAIQRLQPLEQAHLTARHLAELVTGNSPSARVRMQLEAYVLAARLEEVVTAANTRLHIMSEGRYNLSHSDHQAARGARSGLGLEITDSWTGRPRKTDTLSGGESFFASLSLALGLADVVTHEAGGNPLDTLFIDEGFGTLDEDTLHKVLDVLDSLRAHDRTVGVISHVPELRRRITHRLHVRKSPAGSTLAHLTEAAE
>NZ_CP018870|7442:79194|17421_17715_-|WP_075969480.1|DBSCAN-SWA
MEMVERLPFGMRTAVEATYVRCALCGAFGELVLDSGRLDEALARARDHVRETHPGADIPEALRLVPDVAFPPDGCRDVVEWVEQYNARNTLPVPGPR
>NZ_CP018870|7442:79194|43603_43849_-|WP_075969496.1|DBSCAN-SWA
MEKTWFEEVFRRRPHPMLRLLGNLLLGAAQLVFVVAVITHFHSDWRWLVVPMGLWAMLADGRGVALAVQDLRRRDPAPAPE
>NZ_CP018870|7442:79194|46381_47278_-|WP_075969500.1|DBSCAN-SWA
MRAKTLDRIASYQESKDRWNLFRSLKNLIEQAVRDYEHRALVELLQNAHDAHDADDPGGRVLIRLDHDEGPHGAVYVANTGRPVSGSNFDAMTYIAQSDKRPEEGIGNKGIGFKSVLQLTGAPQVYSVAGAGSRVFDGYRFTFADETSLKDLLGGDVTLAAEVAADVFHLCLPVPLDGVPDAVNGFAADGYVTVLRLPLKSEEARAEAAEQLTALSADPPVLLFLRRIGSLTIEERQDGEVARRTLVRTERVDAVLDRLTVSTARVATTCFILRVRTTPVPAISHRRAPSVQPTRHET
>NZ_CP018870|7442:79194|45290_45707_+|WP_075969498.1|DBSCAN-SWA
MGTWGTGPFDSDLAADFVDQLEGLAHQQVIALLERAFQRVTDSEERVDGGDGAEAVAAGALVASTLPDSPIVIDPDDGPREPLPKLPASLRASAKLALDRVLQDGSELTTGWVDSADANQWRQEVRQILQALETPTDH
>NZ_CP018870|7442:79194|43935_44262_-|WP_159393486.1|DBSCAN-SWA
MVRRKKEKKKRPDWGIPKGIVLLATPEGWRHSVLTMEGGMLCGRLDVPINTDPQDARAAAARMVTELARDFHDTDVEVSWDPPREPWSWTAQVTLPAGTEPSPPDSEG
>NZ_CP018870|7442:79194|12172_12484_-|WP_157879710.1|DBSCAN-SWA
MTGRQRRAGGSALAGLVLATAGWWAQWSGYEVVGTALTLLAGTVVLAGAWRSGVLHLPQHEAGRQATQQQRARDSGCRCSEGSSSCAPCSVLYGPLHLLATLL
>NZ_CP018870|7442:79194|7442_8201_+|WP_075969472.1|transposase|DBSCAN-SWA
MDSGSGFEAVFLDPVGQSVQQRWADAAMTVAFEELPPVSAFPVVPGRRWGPGLWWSATTGRHVAAGSNAMRTQLMALDRDPRVTGLAGRPVRLLWRDERGRVRSWVPQLFARYRDGTGLLADCPSHPDAGGERALGAAHAVARACGDIGWAYRRLSPLDDVPASNLKWLAGYRHPRNAGRPGLTPAAVEAFARPRPLIEGAEAVGDPIEVLPVVFHALWHGQLTTDLEAPLHECVPVGPRDWNGLGRTGGAG
>NZ_CP018870|7442:79194|79035_79194_-|WP_107484691.1|protease|DBSCAN-SWA
MVAAHELGHALGLCHKSGSGKNAVSSVMWPDVAQYPDAPTDVDKANVKKLWG
>NZ_CP018870|7442:79194|32261_33899_-|WP_159393483.1|DBSCAN-SWA
MVSLSLLLPQQMAGATPAAASPAAGSAVVDPPLADGQVQQVGPGVYSTADKSFEIYETDVAVGLMSRSHTVTVQPDGVSRPESAPVARADMGIFGPGWEAEFVGGQLNRKLEQSGNTAVVTDLTMNAAATYALKSSLDFPDGGGVRKYATPEGDTLTETTRFNEATGTMVSTAVESANAATSLPDEDLSADADATAPSNFAQLAPTYTWKQVGTGANSWRVTGVGTAANSALSTVTYDTAGRVATVKDAEIGETTSRLLTVKYSTATTATGTTPGEFTGRAREITLTDGATVQTLARYSYDATGRLRSVANPAEGIDAASSYSYDTTGRVSAVASPANGNWELTFPAGSASPNVEPVGPARPAADAPLEGAGGITDPAAGPLPTDFINGEITDPQAYPRHCSAATDWLWYLKRNCAAWAAHYGWHKPTFKTTPTNHRVVGINYDGCSTPGPNVSRPGGFNFRTACDMHDYGYGLIGNTYKGYSYYLDRSKKSNVENAFHTTMKTYSCKAYFILRRPGCNNWAYAYYKAVSNQRWGGNPKNGADAT
>NZ_CP018870|7442:79194|29737_30370_-|WP_079273399.1|DBSCAN-SWA
MTHRGDWTGDAKEDIVARVGGELRVYPNRGDGTLGAHIKIGSGLPTTAQVVGAGDVTKDGHPDLLVQHSNKLYLYAGAAGPAPSVAAPVIIGTSGWDVMDLTAPGDADHDGRVDLLARDTRDGILYHYLGQPDGKTFSDRTEYGRGYTNAFRPLIAGAADANRDGIADMWATAADGTLKFYKGDTSIHGPVDGPSIQVGSGGWGAIKSIS
>NZ_CP018870|7442:79194|12999_15438_+|WP_159393482.1|DBSCAN-SWA
MGEVWAASDLRLRRTVAVKTVLISHLRDERLAAQVLARFRREGEAAARLNHRNIAVVHDLGEHRETSADGQVEVSPFLVMEFLEGRDLATVLREDHPGGLPLEQVVEYGAQVCDGLAAAHTQNIVHRDIKPANLMLLDDGTVKICDFGIAQVQDGTIGLTMTGALLGSPHYMAPEQLRGQTPTHSADLYALGASLYELLTGRPLFTADSAYAIIAMHLSTTPEPPSTRQPAIPPDIDNLITSLIAKDPAGRPPTAKDVAARLRTAHLAPGPTPVPAAEASETDEQLLQRDAEAGDSDAMYSLAWLLQEADRIDEAETWYRKAADAGQIDAMNNLGVLLENTGRTNEAETWYRKAADAGQIDARNNLGVLLENTGRTDEAETWYRKAADAGNTDAMNNLGLLLENTGRTDEAETWYRKAADTGDTDAMYSLGVVLAGTGRTDEAETWYRKAADTGHTDAMTNLGVVLAYSGRTDEAETWYRKAADAGQMNATANLGVVLAGTGRTNEAETWYRKATDAGNTDAMHGLGVLLANTGRTDEAETWYRKAIDAGNTDAMNDLGALLHNTGRETEAQPWFQRAAEAGHTNAMNNLALLLHNTGRETEAEPWYRRAVDAGNTNAMNNLALLLENTGRETEAEPWYQRAVDAGNTNAMNNLGMVLEDAGRTNEAETWYRKATDAGNTGAMTNLGLLLENTGRTNEAETWYRKATDAGQIKAMNNLGVLLQTTGRETEAEPWYQRAADAGNTEAMNNLGVVLQGTGRTAEAETWYRRAAEAGNAPAMNNLARLLQNTGRAAEAETWYQRAAGNPDGEIRA
>NZ_CP018870|7442:79194|68009_68519_-|WP_075971902.1|DBSCAN-SWA
MRHDWSGPAPDGWENRDWRNVPGPFYTAGTDNCFTGRQCAPEHVAYEDEYCTEFVYRQPVEVAGVHELTCAGECDPFGAYGGDGDRHWTPELVQDWWSERRRAREWAVRVGWGEWATSEREQFRDAAAGARAYLAHLDHGLGEYLRDYMFWLSEGRPATPGERLPELDA
>NZ_CP018870|7442:79194|73837_74896_+|WP_075969515.1|DBSCAN-SWA
MIATVLWERELHQRGGASVFVVGPDCVVLHERHTRLVCLERADGAVRWDVPLGTWPRGIVLAGDCVLVLPQAPNLLSCIDLRTGASLWSAPTPRWTGNLAVHSDTVVIGGWRGYTPMSGLDLADGSVRWTTSSPVTSVRTLAWAGGVLTGSGYEAVLLDPADGSDLARWRLPDPLAGPDAKAFVPLDTERVVAVCEASSLLTFGIGADEPARLGSYDPFGAVGYVHGSVWMLRSGRGFLAVDPADGTSRWSVEADRRVVVDPLPYADGLLVGDANGGMRQLGPDGKTVEGCSLPGRRLDALAAAGDGGLFFAAKGTFGSFTLAPKAGRPTTPAALSETPGPNVADIARVAEH
>NZ_CP018870|7442:79194|34624_34843_-|WP_159393484.1|DBSCAN-SWA
MPIRRVRVVAVSAAVVAMAAVAGWDPAALLGRSKAKEAVVRVDQSGYVTGEVKVAAVMGDEEALAGAGFVVP
>NZ_CP018870|7442:79194|78481_79039_-|WP_075969519.1|DBSCAN-SWA
MIMGVKMWVGGCLVAAVAAAGAAWFTTAPETGTTHAVCGPDLGRDDVVAARSRAVAVVEAVENTRYREDGGSAYLTTRVKTLEAFKGEFGDVLEVTQGVKNGGSPGRYATEDPDRYAVLEPGRRYVIAVQSGSTTGAAGTEAWAWYAEPAERGLVGEREHWQEAIATPPETAASSACEDIDAPAG
>NZ_CP018870|7442:79194|64851_65478_-|WP_107484688.1|transposase|DBSCAN-SWA
MNRCQFVDDHQRRFGVKRLCDLLRIARSSFYYWRRTAAARTARQAAEAGLAARIRKVHEESDGTYGAPRITAELRDEGERINHKRVARIMRTIGIEGVRLRRRHRTTVADPAATKAPDLVGRDFTAAEVNTLRGGLLGRCLLRGLLLRRRHLVHGRLSPGLVVGLAAQLAGVGDGLLQRGHQVHDRGRRRLLIVGRGSRCSAFAAMTS
>NZ_CP018870|7442:79194|76188_76545_-|WP_075969517.1|DBSCAN-SWA
MSAGIAPDGPHTDIDGLCEQIRGSLAGWAPRLLGVHVPRSVCGPAEVARLVGAVANAAELTGLPRDGATARAELHTSAARASAAGERAGADVRAELTAVRAGCRRAAVALGLPVPVTL
>NZ_CP018870|7442:79194|47522_47936_-|WP_075969501.1|DBSCAN-SWA
MDPLLHLDRTLDDLDPPRWEAVPANATRLVRTVHGLRRVPLGELRPADLRTLLAQQVALPFVLPLAVRLLAEEPLLDAYFYEGDLLLATVTAPEGAWAALPELEARLRTIVAGLPGAAVKELPRGSDTDLARFIARG
>NZ_CP018870|7442:79194|15492_16107_-|WP_075969478.1|DBSCAN-SWA
MHPEFDRADVVNWLLAHDKITLPAGAGQASLLVRGERGATGRFRLDAPWLGLADDIEGTDRLSGWVADDADADALAALAAGPVGATLTRLTAPGAGPLAVLGDVRVTDRLWSGSGGLRITLEWPARLRGTTAHTGNGGVVATASRRPGPARTACAPATTAAAWTQSCGATNTAARRPPVLDWHAGGGLRCAQLGRGSVASVTSA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
5743:5759	attL	NA	NA	NA	NA
WP_075969472.1|7442_8201_+|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
WP_075969473.1|8197_10315_+|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_075971904.1|10398_11367_+	AAA family ATPase	NA	NA	NA	NA
WP_075969474.1|11727_11994_-	hypothetical protein	NA	NA	NA	NA
WP_157879710.1|12172_12484_-	hypothetical protein	NA	NA	NA	NA
WP_075969476.1|12489_12810_-	hypothetical protein	NA	NA	NA	NA
WP_159393482.1|12999_15438_+	tetratricopeptide repeat protein	M1PCM5	Moumouvirus	4.0e-16	28.6
WP_075969478.1|15492_16107_-	hypothetical protein	NA	NA	NA	NA
WP_075969480.1|17421_17715_-	hypothetical protein	NA	NA	NA	NA
WP_075969482.1|18273_19032_-	hypothetical protein	NA	NA	NA	NA
WP_079273398.1|19024_22894_-	RHS repeat protein	A0A2H4JFP5	uncultured_Caudovirales_phage	7.6e-22	36.7
WP_075969484.1|23679_24237_-	hypothetical protein	NA	NA	NA	NA
WP_075971905.1|24236_24650_-	hypothetical protein	NA	NA	NA	NA
WP_079273053.1|25400_25631_+	hypothetical protein	NA	NA	NA	NA
WP_075969486.1|25926_26481_-	DNA-binding protein	NA	NA	NA	NA
WP_079273399.1|29737_30370_-	VCBS repeat-containing protein	NA	NA	NA	NA
WP_159393483.1|32261_33899_-	phospholipase	NA	NA	NA	NA
WP_159393484.1|34624_34843_-	hypothetical protein	NA	NA	NA	NA
WP_075969491.1|35013_35307_+	hypothetical protein	NA	NA	NA	NA
WP_159393485.1|35820_36381_-	hypothetical protein	NA	NA	NA	NA
WP_075969493.1|36797_37001_-	hypothetical protein	NA	NA	NA	NA
WP_045322884.1|37114_37378_-	hypothetical protein	NA	NA	NA	NA
WP_045322885.1|37464_37725_+	hypothetical protein	NA	NA	NA	NA
WP_079273056.1|38568_39822_+	DUF2716 domain-containing protein	NA	NA	NA	NA
WP_079273057.1|40233_41997_+	hypothetical protein	NA	NA	NA	NA
40620:40636	attR	NA	NA	NA	NA
WP_045322888.1|42495_42783_+	hypothetical protein	NA	NA	NA	NA
WP_079273058.1|43040_43478_-	HNH endonuclease	NA	NA	NA	NA
WP_075969496.1|43603_43849_-	hypothetical protein	NA	NA	NA	NA
WP_159393486.1|43935_44262_-	hypothetical protein	NA	NA	NA	NA
WP_075969498.1|45290_45707_+	DUF4259 domain-containing protein	NA	NA	NA	NA
WP_075969499.1|45927_46467_+	2'-5' RNA ligase family protein	NA	NA	NA	NA
WP_075969500.1|46381_47278_-	ATP-binding protein	NA	NA	NA	NA
WP_075969501.1|47522_47936_-	hypothetical protein	NA	NA	NA	NA
WP_159393487.1|48193_48670_+	hypothetical protein	NA	NA	NA	NA
WP_075969503.1|49342_49876_-	hypothetical protein	NA	NA	NA	NA
WP_075969504.1|50219_51317_-	PASTA domain-containing protein	NA	NA	NA	NA
WP_159393488.1|51643_52234_-	hypothetical protein	NA	NA	NA	NA
WP_075969506.1|53798_54182_-	hypothetical protein	NA	NA	NA	NA
WP_075971903.1|54395_54725_+	hypothetical protein	NA	NA	NA	NA
WP_107484686.1|55316_56735_+|transposase	IS21 family transposase	NA	NA	NA	NA
WP_075969508.1|56731_57505_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	6.1e-56	46.4
WP_107484881.1|57516_57693_-	hypothetical protein	NA	NA	NA	NA
WP_075969509.1|58227_61236_-	SMC family ATPase	NA	NA	NA	NA
WP_075969510.1|61237_62437_-	exonuclease SbcCD subunit D	NA	NA	NA	NA
WP_030035897.1|62707_64537_-	ATP-binding protein	NA	NA	NA	NA
WP_107484688.1|64851_65478_-|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	9.5e-07	31.3
WP_079273395.1|65474_65786_-|transposase	transposase	NA	NA	NA	NA
WP_079273060.1|67532_67844_-	hypothetical protein	NA	NA	NA	NA
WP_075971902.1|68009_68519_-	hypothetical protein	NA	NA	NA	NA
WP_075969513.1|71766_72237_-	hypothetical protein	NA	NA	NA	NA
WP_075969514.1|72472_73051_+	ATP-binding protein	NA	NA	NA	NA
WP_075969515.1|73837_74896_+	PQQ-binding-like beta-propeller repeat protein	NA	NA	NA	NA
WP_075969516.1|75367_75883_+	hypothetical protein	NA	NA	NA	NA
WP_075969517.1|76188_76545_-	hypothetical protein	NA	NA	NA	NA
WP_075969518.1|76757_77222_+	hypothetical protein	NA	NA	NA	NA
WP_075969519.1|78481_79039_-	hypothetical protein	NA	NA	NA	NA
WP_107484691.1|79035_79194_-|protease	matrixin family metalloprotease	NA	NA	NA	NA

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NZ_CP018870|1663965:1670909|DBSCAN-SWA
GATGGACGATCTGACGCTGGTACGGGACCACACGGTCTACCGGTGCGTGATGGGCTCCCGGGCCTTCGGGCTGGCCACGGAGGGCAGCGACACCGACCGGCGCGGCGTCTACCTCGCCCCGACACCGCTGTTCTGGGGGTTCGACAAGCCCCCCACGCATGTGGAGGGCCCCCGGGACGAGGAGTTCTCCTGGGAGCTGGAGCGCTTCTGCGAACTCGCCCTGCGCGCCAACCCGAACATCCTGGAGTGCCTGCACTCACCCCTGGTGGAGCAGGTCGGCCCGGTCGGCGCGGAGCTGCTGTCGCTGCGCGCGGCCTTCCTCTCGCGCCGCGCCCACACCAGCTTCAGCCGGTACGCGGCCTCCCAGCACGGCAAGCTCCTCGCGGACGTCCGCGTCCACGGCGCGCCTCGCTGGAAGCACGCCATGCACCTGCTGCGCCTGCTGCTCTCCTGCCGCGACCTGCTGCGCACCGGTGTTCTGACCATCGACGCGGGCCCGCACCGCGAGCGGCTCCTCTCGGTGCGCCGCGGGGAGCTCACCTGGGACGAGGTCGACGCCTGGATGGCGGGCCTGGTGGAGGAGACGGACAGGGCGCTGGCCGGGACCCCCCTGCCGGAGGACCCGGACCGGGCCCGGGTGGAGGACTTCCTCGTCCGCACCCGGCGCGCCTCGGCCGCGTAGGCCGTGTCCAGGCCCGTCCCCGCTCAGTCGCCCCGGATCCGCCGCCGGACGACGAAGGCGTCCAGCGCCTCGTACGCGGACCCGTGCTCGGGCAGCGCGGTGCCCGCCTGCGCGGCGTCCAGCACCGCGTGCAGGGCCTCGAAGTCCTCGCGTACCACGGCGGCGGGCGGGCCCTCGTAGCCCCCGTGCTCGGCGGCCGCCTTCGCCTCGATCAGGGCGGCGAGGTACGGCGGTGCCTGCGGCACCTCGGTCAGCAGGGTCGGCAGGTGGGCCTGCACCTCGGCCGACCGCATCAGGTGGATGCCGGTGAGCAGCGCCCGGAAGGCGTAGAGGAGCGGCTTGAGTTCGGCGGCCTTCTCGAACAGCCGCCACTGCGTGTTGGCGAACCCCCGGTAGTGGTGGGCGTGGTGGGACGTCAGCACGCCCGGTGCCAGGGCGGCCAGCTCCTCGTGCGCGGGTGTCGTGTGCACGACGAGCGGGGAGAGCAGCTGCTCCAGTACGTAGCCGTTGCGGCCCAGCATCAGGCGGACGAACTTGCGCAGGTCGTGCGTGACGAGGTCCATCTCCACGCCGTCCCGGTCCCACATCCGCGACCGGGTCTCCTCGGGGGCGCGCAGGCCCAGGAGGTCCTCCGCCGGCAGCAGGTGTGCGCCTCGCAGGTCGATGTCGGAGTCCCGCGAGGGGAAGCCGTACAGGTGGGCTCCGGAGACGGTGGCGAAGAGCAGCGGGTCGGGCTGCTCGGCCACGACGGGGGTCAGGTCGATGCTCAGGGCGTCCAGCACGGTTCACGCGTCCCAGAGGGTGCCGAAGGCCAGGAGCTCGTCCCGGTACTCGATGCGGCCCTCCCAGGCGCGCGGCCAGGCGTCCGCTCCGAGGTGCGCTCCGGCGAAGGCCCCGGCGAGGCAGGCGATGGAGTCGGAGTCGCCCCTGGTGCAGGCGGCGCGGCGCAGGGCGGTGAGGGGTTCCCCGGGGAAGAGGAGGAAGCACTGCAGGGCGGTGGCGAGTGCCTCCTCGGCGATCCAGCCGTCGCCGGTGGTCAGGCAGGGGTCGGTCTCCGGGGACGGGGAGCGCAGGGCGGCCGAGAGCCGGTCCAGCACCTCCAGGCACTCGTCCCAGCCGCGCGCGATGAAGGACTCCGGCGTGGCGTCGGAGGCGGTCCGCATCCAGAGGTCGCCGAGCCAGCGCTCGTGGTAACGGGTGCGGTTCTCCAGGGCGTAGGAGCGCAGCCGCCCGACGAGGCCGGTGACCTCGGTGCCGGAGGCCAGCAGGTGCACCGCCCGCGCCGTCAGGTCGGAGGCGGCGAGCGCGGTGGGGTGGCCGTGGGTGAGGGCGGACTGGAGCTGGGCGGCGCCGGCCCGTTCCTCGTCGGTCCAGCCGGGGACCAGCCCGACGGGGGCGACGCGCATGTTCGCCCCACAGCCCTTGGAGCCGGTCCGGCTGGCGTCGCGCCAGTCGCGCTGCGGGTCGTTCAGCAGGTTGCAGGCCTGCAGGCAGGTGTTGCCGGGCGCGCGGTTGTTCTCCGGGGAGTGGTACCAGTCGACGAACTCCTCCCGGACCGGGCGGGTGAGGTTCGACGGGCCCACCGGGCCGCGGTCGGCCGCGGTCCGTATGCCGCGCGCCAGGGCGAGGGTCATCTGGGTGTCGTCGGTGACGATCGCCGGGTCGGGCAGGCGCATCTCGCGCCACGGGCCGGTCTTGGCGAGGATCGAGGGCACGTCGTTGAACTCGGTCGGGAAGCCCAGGGCGTCGCCCAGGGCCAGGCCGGTCAGCGCGCCGGTCGCGGCTCGCTTCGTCATCGGGTGGGTCCTTCCGGTCGGAGCAGAGGTGGATGGAGGGCGGTGGCCGGGCCGGCCCGGTAGAGGGCGGCCGGTTTGCCGCGGCCCCCGGTGAGCCGGGCGGCGCCCGGTACGGCCTCGACGAAGCCGGGTGTCGTCAGGACCTTGCGGCGGAAGTTGGGGCGGTCGAGCACGGTGTCCCAGACGGTCTCGTAGACGGCCAGGAGCTCGCCGAGGGTGAACTCGGGCGGGCAGAAGGCGGTGGCGAGGCAGGTGTACTCCAGCTTCGAGCGGACCCGTTCCCGCGCGTCGGCCAGGATCACCGCGTGGTCGAAGGCCAGGTCCGGCGCCTCGCCCAGGGGCAGCCAGCGGGCCTGCGCCGCGTCCCCGCCGCCTTCGGCCGCCGGCTCGGGAAGGTCCGGGACGAGGGCGGTGAACGCCACCGAGACGACCCGCATCCGGGGATCGCGGTCGGGCTCGCTGTAGGTGCGCAGCTGCTCCAGGTGCAGGTCGGCCACGACCTGCTGCGGCAGGCCGGTCTCCTCGGCCAGTTCCCGCCGGGCGGCCGTCTCGGCGGACTCCCTGGGCAGCACGAACCCGCCGGGCAGCGCCCAGGCGCCCGCGTACGGCTCCTGGCCGCGCCGGATCAGCAGGACGTGCAGGGCGCCGCCGCGCACGGTGAACACGGCGAGGTCGACGGTCACCGCGAACGGCTCGAAGGCGTACGGGTCATAGCCCGGCTCCGGCGCGGAGCTCATCGGTTCTCCGGGAGCGGGTCGGCGAAGCGCCAGCCCTCGGCGAGCAGTTCGTCGACGGCCGCGACGGCCGTGGCCAGCCGCTCCCGCCGGCTGCCGCGCAGGGAGAGGAAGCGGCGGCCGGTGGCCTCCAGCTCCTCGCGGAACCGCCGGGTCATCCAGGGTCTGAGCTCGGGTCCGTCGCGCAGCCCGTCGTCCTCGAAGGGCACGTCGGCGTCCTCGGTGAGCAGGTAGAGGTCCCGGTGCGTGCGGGCGGCGATCCGCTCGACGTCGGCGTTGCGGCCGCCCATGTACCGCTCGTGCCAGATGCCGGTGGCGAAGGAGTCGGTGTCGCAGACCAGCACCGGGGAGCCCTGGCGGGCCGCCTGCTCCTCCTGCTCGTCCTGGCGGCGGGCGATCAGGGGGAACTCCTCGGAGGTGAAGGAGACGTCCGCCCACGTGGCAGCCGGGTCCGAGGCCCTGGCCGCCGCGAGCTTGTCCTCGCTGTAGCGGCGTCCGTACTCGGCGACCCAGCCGGTCGCGGCCCAGACCCCGCCGCGCGCCCGGAGGTGTGCCGCCAGGTCCCGCGACAGTGTCGTCGTCCCGGTGGACTCGGCGCCGAGTACGACGACGCGGCGTGCCAGGCGGGCCCGTACGGCGGGTCCCAGGAAGTCCCAGCAGGCGGCGGGGTCGGCGCGGACGGCCGTCCCGGACACCGGGAAGAGGGTCCGGGCGGGGTCCACGCAGACCTCTTCGGCGCCGAACCTGCGGGCGAGTTCGGCCCCGTACTCCTCGGAGGTGAAGACGGCGTCCACGGGCCGGCCGACCGCGGCCCGGAAGATCGCCATGTGGGCCTCCCAGACCGCCGGGTCGTGCAGGTCGACGGGGATGTCGTCGACGGCTCCGACGACGTCGGCGTCCGGGTGGGCCTCGCGCATCCAGGCGACGCGGTCGGCGAGCGGCACCGACTCCACGGAGGCCGCGCAGACCAGTACGGTCAGCCGCTCGCAGCGGTCCTGGGCGGTACGGACGAGGTGGTGGTGGCCGGCGTGCGGCGGGTAGAACTTGCCGAGGACCAGGCCGTGGCCGAAGCGCCTCATGCCGTCACCCCCGCGGCCGCCGCGGGGGCGGTGCGCTCGGTGAGCGTCCGCCGCCAGCCCAGCAGCCCTGCGACGCACAGCCCCAGGAAGCCGATGTAGAGCAGGGCGGTGAGGTGGAGCCCCTTGTGGACGTACAGGGGGATGTAGACGAGGTCGGCGGCGATCCACAGCCACCAGGACTCGACGAGCTTGCGGCACTGGCCGTAGGTGGCCGCGAGGGAGAGCACGGTCGTGACGGCGTCCCAGAAGGGGACGGTGGAGTCGGTGGCCCGGGCGAGGAGCAGGGTCAGGCCGAGCGTCGCCACCGCCCCGGCCGCGGCCAGCCAGGCCCATTCGGTGCGCGTGGTGTGCCGCACCGGCAGGGTTTCGGCGGTTCCCGGTCCACCCCCGTGGGTCCAGGACCACCAGCCGTACGCGGCCAGGGCGATGAAGACGATCTGGAGCCCGGCGTCGGCGTAGAGGCCGGCCTGGGCGAAGAGGACGATGAAGAAGACGTTGTTGGCGATGCCGATCGGCCAGTTGGCGATGTGCTGACGGGCCACCAGCCAGACGCACAGGGCGCCTGTGGCGAAGCCGAGCACCTCGGTCCAGCTCAGAGTCCAGTTCATGCCGAGCCCCACTCCCTTTAATAGTCACTGTGACTATAAACAGGGGTGCCGGGTCGGGGCAAGGGAAAAGCCCGCAGCGCCGGGGGCACTGCGGGCTTTCCTCGTGGAGCGGTCCTGCCGGCCGGTCCTACAGGCCGACCTCGCGCATCAGCATGCCGACCTCGGTGTTGGTCAGGCGGCGCAGCCAGCCGGACTTCTGGTCGCCCAGCTCGATGGGGCCGAAGGAGGTCCGCACGAGCTTGTCGACGGGGAAGCCCGCCTCCGACAGCATGCGGCGGACGATGTGCTTGCGGCCCTCGTGGAGGGTCACCTCGACCATGTAGTTCTTGCCGACCTGGTCCAGGACGCGGAAGTTGTCGGCGCGCGCCCAGCCGTCCTCCAGCTCGATGCCGTCCTTGAGGCGCTTGCCGATGTCACGCGGCAGCGAGCCGGTGATGGCGGCGACGTAGGTCTTCTTCACGCCGTACTTCGGGTGCGTGAGGCGGTGGGCCAGCTCGCCGTGGTTGGTGAGCAGGATGATGCCCTCGGTCTCGGTGTCCAGCCGGCCGACGTGGAACAGGCGCGTCTCACGGTTGGTGACGTAGTCGCCGAGGCACTGGCGGCCGTCCGGGTCCTCCATGGTGGACACGACACCGGCGGGCTTGTTCAGCGCGAAGAACAGGTACGACTGGGTGGCGACGGTCAGGCCGTCCACCTTGATCTCGTCCTTCGGCTGGACGCGCTTGCCCTGCTCGGTGACGATCTCGCCGTTGACCTCGACGCGGGCCTGCTCGATGAGCTCCTCACAGGCGCGGCGCGAGCCCATGCCGGCACGGGCGAGGACCTTCTGCAGGCGCTCGCCCTCCTGCTCGGCGCCGGGGAAGGTCTTCGGGGTCCGGATCACGGGCTTGTCGGCGTACCGGTCGCGCACGCGCTCCTCGATGCGCGCGTCGAGCTCGCGCGGACGGGACTGGCCGCTGCGGCTGCCCGGGCCGCGGCGCGGGCCGCCGGCGCCGCCGATGCCGGGGGTCCTGGAAGCCTTGGGGCCGCCCTTCGCGCCGCCGCGCGCGGCGGCGCCGCGGGCGCCCCGGGTGCGCTCGCCCTCGGGGCCCACGTCGTAGCGGCGCTCCTCCGGACGGGGGTTGCGGGGACGCTGGGGCGCCTGGTCACGGTCACGGTCGCGTGAGCCGCCCTGACCGCCCTGCCCGCCCTGACCGCCGCGGTAGCCGCCGCTGCCGGAACCGCCGCCGGAGCCACCCCGGTAGCCGCCGCTGCCGGAGCCTCCGCGGTAGCCACCGCCGCCACCCTGGCCGCCGCCACGGGCGCTACCGCGCCCGCCGCCACCGCCGCCGCTGTTCCTGTTGCCACCGTTGCCGTTGCCGCTGCTTCGCATCAAAGTTCCGTCGTCTTGTCGTCTTCATCGGTGTCCGGTGCGTCCGGATCGAACGACGGCACACCTTCTTGCGTCTCGGCTTCGATCGCGTCCGCCTCGGGGAGGAAGGGCGCGAGCTCCGGGAGCTCGTCCAGGCCGCGCAGGCCCATCCGCTCCAGAAAGTAGTTCGTCGTCCTGTACAGGATCGCACCTGTTTCGGGTTCCGTCCCCGCCTCCTCCACCAGACCGCGCTGGAGCAGGGTCCGCATGACCCCGTCGCAGTTGACTCCGCGCACGGCGGAGACCCGCGACCGGCTCACCGGCTGGCGGTACGCGACGACCGCCAGGGTCTCCAGCGCCGCCTGTGTGAGCCGGGCCTGCCGGCCGTCCAGGACGAAGCCCTCCACGGCCGGGGCGTACTCCGCCCGGGTGTAGAACCGCCAGCCGCCCGCGACGACCCGCAGCTCGAAGCCCCTGCGTGCGGCCGTGTACTCGTCGGCGAGCTCCCGCAGCGCGTCCGCGACCTCGCGCGGGGTGCGCTCCAGCACCTTGGCCAGGTGCTCCTCGGTCGCGGGCTCGTCGACGACCATGAGGACGGCCTCCAGGGCGGGCTTCAGTGCCAGCGCGGCCACCGCGCTGGCGTTGCCGTCGCCGCGGTCGCTGCGGTCGCTGCGGTCGCTGCGGTCGCTGCTCAA

Protein sequences of DBSCAN-SWA_2

>NZ_CP018870|1663965:1670909|1668251_1668863_-|WP_045321830.1|DBSCAN-SWA
MNWTLSWTEVLGFATGALCVWLVARQHIANWPIGIANNVFFIVLFAQAGLYADAGLQIVFIALAAYGWWSWTHGGGPGTAETLPVRHTTRTEWAWLAAAGAVATLGLTLLLARATDSTVPFWDAVTTVLSLAATYGQCRKLVESWWLWIAADLVYIPLYVHKGLHLTALLYIGFLGLCVAGLLGWRRTLTERTAPAAAAGVTA
>NZ_CP018870|1663965:1670909|1664669_1665428_-|WP_045321829.1|DBSCAN-SWA
MLDALSIDLTPVVAEQPDPLLFATVSGAHLYGFPSRDSDIDLRGAHLLPAEDLLGLRAPEETRSRMWDRDGVEMDLVTHDLRKFVRLMLGRNGYVLEQLLSPLVVHTTPAHEELAALAPGVLTSHHAHHYRGFANTQWRLFEKAAELKPLLYAFRALLTGIHLMRSAEVQAHLPTLLTEVPQAPPYLAALIEAKAAAEHGGYEGPPAAVVREDFEALHAVLDAAQAGTALPEHGSAYEALDAFVVRRRIRGD
>NZ_CP018870|1663965:1670909|1663965_1664646_+|WP_045321828.1|DBSCAN-SWA
MDDLTLVRDHTVYRCVMGSRAFGLATEGSDTDRRGVYLAPTPLFWGFDKPPTHVEGPRDEEFSWELERFCELALRANPNILECLHSPLVEQVGPVGAELLSLRAAFLSRRAHTSFSRYAASQHGKLLADVRVHGAPRWKHAMHLLRLLLSCRDLLRTGVLTIDAGPHRERLLSVRRGELTWDEVDAWMAGLVEETDRALAGTPLPEDPDRARVEDFLVRTRRASAA
>NZ_CP018870|1663965:1670909|1666438_1667179_-|WP_030029365.1|DBSCAN-SWA
MSSAPEPGYDPYAFEPFAVTVDLAVFTVRGGALHVLLIRRGQEPYAGAWALPGGFVLPRESAETAARRELAEETGLPQQVVADLHLEQLRTYSEPDRDPRMRVVSVAFTALVPDLPEPAAEGGGDAAQARWLPLGEAPDLAFDHAVILADARERVRSKLEYTCLATAFCPPEFTLGELLAVYETVWDTVLDRPNFRRKVLTTPGFVEAVPGAARLTGGRGKPAALYRAGPATALHPPLLRPEGPTR
>NZ_CP018870|1663965:1670909|1670234_1670909_-|WP_075970054.1|DBSCAN-SWA
MSSDRSDRSDRSDRGDGNASAVAALALKPALEAVLMVVDEPATEEHLAKVLERTPREVADALRELADEYTAARRGFELRVVAGGWRFYTRAEYAPAVEGFVLDGRQARLTQAALETLAVVAYRQPVSRSRVSAVRGVNCDGVMRTLLQRGLVEEAGTEPETGAILYRTTNYFLERMGLRGLDELPELAPFLPEADAIEAETQEGVPSFDPDAPDTDEDDKTTEL
>NZ_CP018870|1663965:1670909|1665431_1666442_-|WP_030029366.1|DBSCAN-SWA
MTKRAATGALTGLALGDALGFPTEFNDVPSILAKTGPWREMRLPDPAIVTDDTQMTLALARGIRTAADRGPVGPSNLTRPVREEFVDWYHSPENNRAPGNTCLQACNLLNDPQRDWRDASRTGSKGCGANMRVAPVGLVPGWTDEERAGAAQLQSALTHGHPTALAASDLTARAVHLLASGTEVTGLVGRLRSYALENRTRYHERWLGDLWMRTASDATPESFIARGWDECLEVLDRLSAALRSPSPETDPCLTTGDGWIAEEALATALQCFLLFPGEPLTALRRAACTRGDSDSIACLAGAFAGAHLGADAWPRAWEGRIEYRDELLAFGTLWDA
>NZ_CP018870|1663965:1670909|1667175_1668255_-|WP_030029364.1|DBSCAN-SWA
MRRFGHGLVLGKFYPPHAGHHHLVRTAQDRCERLTVLVCAASVESVPLADRVAWMREAHPDADVVGAVDDIPVDLHDPAVWEAHMAIFRAAVGRPVDAVFTSEEYGAELARRFGAEEVCVDPARTLFPVSGTAVRADPAACWDFLGPAVRARLARRVVVLGAESTGTTTLSRDLAAHLRARGGVWAATGWVAEYGRRYSEDKLAAARASDPAATWADVSFTSEEFPLIARRQDEQEEQAARQGSPVLVCDTDSFATGIWHERYMGGRNADVERIAARTHRDLYLLTEDADVPFEDDGLRDGPELRPWMTRRFREELEATGRRFLSLRGSRRERLATAVAAVDELLAEGWRFADPLPENR
>NZ_CP018870|1663965:1670909|1668990_1670235_-|WP_045321831.1|DBSCAN-SWA
MRSSGNGNGGNRNSGGGGGGRGSARGGGQGGGGGYRGGSGSGGYRGGSGGGSGSGGYRGGQGGQGGQGGSRDRDRDQAPQRPRNPRPEERRYDVGPEGERTRGARGAAARGGAKGGPKASRTPGIGGAGGPRRGPGSRSGQSRPRELDARIEERVRDRYADKPVIRTPKTFPGAEQEGERLQKVLARAGMGSRRACEELIEQARVEVNGEIVTEQGKRVQPKDEIKVDGLTVATQSYLFFALNKPAGVVSTMEDPDGRQCLGDYVTNRETRLFHVGRLDTETEGIILLTNHGELAHRLTHPKYGVKKTYVAAITGSLPRDIGKRLKDGIELEDGWARADNFRVLDQVGKNYMVEVTLHEGRKHIVRRMLSEAGFPVDKLVRTSFGPIELGDQKSGWLRRLTNTEVGMLMREVGL

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_045321828.1|1663965_1664646_+	nucleotidyltransferase	A0A1J0GW18	Streptomyces_phage	1.3e-14	37.7
WP_045321829.1|1664669_1665428_-	nucleotidyltransferase	K4K696	Caulobacter_phage	5.2e-07	38.1
WP_030029366.1|1665431_1666442_-	ADP-ribosylglycohydrolase family protein	A0A2D0ZND4	Rhodococcus_phage	1.2e-24	31.3
WP_030029365.1|1666438_1667179_-	NUDIX hydrolase	A0A0E3JJF3	Streptomyces_phage	1.0e-23	47.8
WP_030029364.1|1667175_1668255_-	AAA family ATPase	A0A2K8HHU5	Bacteriophage	9.5e-31	31.9
WP_045321830.1|1668251_1668863_-	nicotinamide mononucleotide transporter	A0A0F6YPU8	Sinorhizobium_phage	6.6e-13	31.8
WP_045321831.1|1668990_1670235_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_075970054.1|1670234_1670909_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	2.4e-11	30.7

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NZ_CP018870|4198340:4255558|DBSCAN-SWA
GTCAGAGCTTCTCGGGGGTGCGGATGCCCAGGAGGGACATGCCCTTCGAGAGGGTGCGGGCCGTCAGCTCGCACAGGAACAGGCGGTTCTCGACCTGCTCCGGAGTGTCGGCCTTGAGGACCGGGCACTCCGAGTAGAACGACGTGTACAGCGACGCCAGCTGGTACAGGTACGCCGCCAGCTTGTGCGGGGCGTGCTCCGCGGCCGCCTCCGCGATCAGCTCGCCGAAGGCGTCCAGGTGCAGACCCAGCGCCCGCTCGGTCGGGGCCAGCGCCACCTCCGGGTGGGCGGCCGGGGTCGCGTCACCGGCCTTGCGCAGGATCGACTGGATACGGGCGTACGCGTACTGGAGGTACACGGACGTGTCACCGTTCAGCGAGACCATCTGGTCCAGGTCGAACTTGTAGTCCCGGGCGGCGGACGTCGACAGGTCGGCGTACTTCACCGCGCCGATGCCCACCTGGGCGCCCCGCTCGGCGATCTCGGCCTCCGTCAGGTCCTGGGCCTTCTCCCGGACCACGGCCGAGGCACGCTCGATCGCCTCGTCCAGCAGGTCCACCAGCCGGACCGTCTCGCCCTCACGGGTCTTGAACGGCTTGCCGTCCTTGCCGAGGACCGTGCCGAAGGCCAGCTGTACGGCCTTGACGTCGTCGTTCAGCCAGCCCGCCCGGCGCGCCGTCTCGAAGACCATCTTGAAGTGGAGCGACTGCCGCGCGTCGACCACGTAGATCAGCTCGGTGGCGCCGAGGTTGGTCACGCGGTCGCGGATCGCCGACAGGTCGGTGGCGGCGTAGCCGAAGCCGCCGTCGGACTTCTGCACGATCAGCGGGGTCGGGTTGCCGTCCGGGCCCTTGACGTCCTCGAAGAACACGCACAGCGCGCCGTTGGAACGGACCGCGACGCCCGACTCCTCCAGCAGCTTGCACGTCTCGACCAGCATGTCGTTGTAGCCGGACTCGCCGACCACGTCCGGGTCCTGGATGTCCATGTCCAGCTTGTTGAAGACCGAGTAGAAGTAGATCTTCGACTCGTCCACGAACCGCTGCCACAGCGCCAGCGTCTCCGCCTCGCCCGCCTGGAGGTCCACCACCCGGGCCCGGGCCCGCGTCTTGAACTCCTCGTCGGAGTCGAACAGGGCGCGCGAGGCCTTGTAGAGGCGGTTCAGGTTGGACATGGCCTCCTCGCCGGAAGCCTGCTCGTCGTCCCCCGCCGACTTGTGGTCCAGCTCGTGCGGGTGCTCCAGCAGGTACTGGATGAGCATGCCGAACTGGGTGCCCCAGTCGCCGATGTGGTGGCGCCGGATGACCTTCTCGCCCGTGAACTCCAGGATCTCCACCATCGCCGCGCCGATCACGGCGGACCGCAGGTGCCCGACGTGCATCTCCTTGGCGACGTTCGGCTGCGCGTAGTCGATCACCGTCGTGCCGGCGGACGCGTTCAGCGGGACGCCGAGCCGGTCGTCGGCCGCGCGGGCCGCCAGCGTCGAGACGATCGCCGAGTCCGCGACGGTGATGTTCAGGAAGCCGGGGCCCGAGACCTCGATCTCCTTGATCAGGTCACCGGCCGGGATGCCCTCGACCACGGTCGTGGCCAGCTCGCGCGGGTTGGCCTTGGCCTTCTTCGCGAGCGCCAGGATGCCGTTGGCCTGGAAGTCGGCCCGGTCGCTTCGTCGCAGCAGCGGGTCGGCGCCACCGGCCTCCGGCAGCGCGGAGGCGAGGGCGTCGGCGACGCGCTGGTTGACGGACGAAGCGAGCGAAGGGACCGAGGCCATGAGCTGCCGTTCCTGTGAGGTTCTGAGGTTCTCTACCGGGGTCGTGCTGGGTCGTGCTTGGGGTCGTGCCGGGGTGCTGCTTGGTTCGTACTCCGTCGGACTTGGGTCTTCCGACAAGAGCCGAGTATCCCACGCGGCCGCCATCCCTTTCGCGGGATATCACTGGGTGGAAGCAACCCCAAAGTGACCCGTTCCGTCTGGGAGAATGGCCGAAGCCAGCATTCGAGATAGAAGGACGTGTCGTGGCTCAGAGCGCGCAGAGCAGCACCGAGACCGACTGGGTCTCCCGTTTCGCGGACGATGTCATCGCCGAGGCGGAGCGCCGAGCCCCGGGCAAAGCAGTGGTCGTCGCCTCCGGCCTCTCGCCCTCCGGCCCGGTCCACCTGGGCAACCTGCGCGAGGTCATGACCCCGCACCTGGTCGCCGACGAGATCCGCCGCCGCGGCCACGAGGTCCGCCACCTCATCTCGTGGGACGACTACGACCGCTTCCGCAAGGTCCCCAAGGGCATCCCCGGCGTCACCGAGGAGTCGCACGCCCGGCACATCGGGCGCCCGCTGACCGCCGTCCCCGCCCCCGAGGGTTCCGCCTACCCGAACTGGGCCGAGCACTTCAAGGCCGCCATGGCCGAGTCCCTGGCCGAGCTCGGCGTCGAGTACGACCCGATCAGCCAGACCGAGCAGTACACCACCGGTGTCTACCGCGAGCAGATCCTGCACGCGATGAAGCACCGCGGCGACATCGACGCCGTCCTCGCCCAGTACCGCACCAAGGCCAAGCCCGGCGGCAAGAAGCCCCAGCAGAAGCAGGTCGACGAGGCCGAGCTGGAGGCCGCCGAGGGCTCCGGCGCCGCCGCCGAGGACGACGGCAGCGCCGGCGAGGGCGGCTACTTCCCGTACAAGCCGTACTGCGGCCAGTGCGGCAAGGACTTCACCAAGGTCACCTCGTACGACGACGAGACCACCGAGATGACCTACGTCTGCACCGAGGACGAGTTCACCGAGACGGTCAAGCTCAGCGAGTTCAACCGCGGCAAGCTCGTCTGGAAGGTCGACTGGCCCATGCGCTGGGCCTTCGAGGGCGTGATCTTCGAGCCCTCCGGCGTCGACCACTCCTCGCCCGGCTCCTCCTTCCAGGTCGGCGGCCAGATCGTCCACATCTTCGGCGGCGAACAGCCCATCGGCCCGATGTACGCCTTCGTCGGCATCAGCGGCATGGCCAAGATGTCCTCCAGCAAGGGCGGGGTCTTCACCCCCGGCGACGCCCTCAAGATCATGGAGCCGCAGCTCCTGCGCTGGCTCTACGCCCGCCGCAGGCCCAACCAGTCCTTCAAGATCGCCTTCGACCAGGAGATCCAGCGCCTCTACGACGAGTGGGACAAGCTGGAGGCCAAGGTCGCCGACGGCTCCGTACTGCCCGCCGACGCCGCCGCCCACAGCCGCGCCGTCCGCGTCGCCTCCCACGAGCTGCCGCGCACCCCCCGCCCGATGCCCTACCGCACCCTCGCGTCGGTCGTCGACATCACCGCCGGACACGACGAGCAGACCCTGCGCATCCTCTCCGACCTGGAGCCGGACAAGCCCCTCACCTCCCTCGACGAGGTACGGCCCCGCCTGGACCGCGCCGAGAACTGGATCACCACCCAGGTCCCCGCCGACCAGCGCACCCTCGTACGCGAGGACCCCGACACGGAGCTGCTGACCTCCCTGGACGACGAGGGCCGCGAATCCCTGCGCCTCCTCCTCGAAGGCCTCGACTCCCACTGGTCGCTCGACGGACTCACCACCCTCGTCTACGGCGTCCCCAAGGTCATGGCCGGCCTCGAACCCGACGCCAAGCCCACCCCCGAGCTCAAGGTCGCCCAGCGCACCTTCTTCGCACTGCTCTACCGGCTCCTCGTCACCCGCGAGACCGGGCCGCGCCTGCCCACGCTGCTCCTCGCCGTCGGCGCGGACCGCGTGCGCAAGCTGCTCGCCGTCTGACACCCCGCCGCCGGAGGCGCACATGCGCGAGGGCCCGCACCCCGAGGGGTGCGGGCCCTTGCGCATACCGGTGTCGCCGGCCTGCCACTACGCGGGCTCGGCCTCACGGTCCTTGTGGTGCTGCTGACGGAACGACGAGATCATCCGCCGCAGCAGAGAACCACTACGCGGGTGCGTCACGCCGTAGCGGTCCGCCAGCATTATGTCGAGGGCCTCAGCGGTCGGATAGTCCTGCGTCTCCTCGGCCAGCGCACAGAACACCTTGTACGCGATCTGCGCGAACTCGACCTCGTCCGGAGAGTCCACCACCGGCACCTGCTCCGGGAACTGCCCGTCCGCCGCCGCCTCGTGACGCGGCTCCGGAATCGGAAGCTGCTGCGCCTGCGGCTCCTCCGGACCCATCGGGGGCAGAACCGGCGTCGGCTCCAGTCCCTCCACGTACTGCGGGTTGTAGCCACCCTCGTACGCGGCCTGCGGGGCCTTCGGAGCAGCGAACCAGGCACTGTTGTGGGCCGCCGGCATCGCCGTCGGATCCACCGCGAACGCCGGCGGGACATGGGCGGCGACCGCCCCGGGCGCACCCTGCTGCACAGCAGACTGCGGAGCCTGGACCGGCTGCTGCGCCTGGGCCTGGAGCGGGTCGGCGGCGCCCGCCGCCGACACCTCAAGCGCCGGAGCCGAACCCGCGAGCTGCTGCTCCAGCGGCGGCAGCACCGCCGGATCGATCCCCGTCGCCGCCAGCGCGTCCGGGGCGGTCTGCGAGAGCGGCACACCGATCCGCGCCAGTTTCAGCGGCATCAACGCCTCCACCGGCGCCTTCTGCCGCCAGAACCGCCCGTACCGCGCCTGCAGCCGCGCCTGGTAGATCAGCCGGTCCTGCTCCATGCCGATCGCCTGCTCGTACGAACGCAGCTCCCACAGCTTCATCCGTCGCCACAGCTTGAACGTCGGCAACGGCGACAGCAGCCACCGCGTGATGCGTACGCCCTCCATGTGCCGGTCCGCCGTGATGTCGGCGATCCGGCCCACCGCGTGCCGGGCGGCCTCCACCGTCACCACGAACAGGATCGGGATCACGGCGTGCATGCCGACACCGAGCGGATCCGGCCACGACGCCGCACCGTTGAACGCGATCGTCGCCGCCGTCAGCAGCCACGCCGTCTGACGCAGCAGCGGGAAGGGGATCCGCATCCACGTCAGCAGCAGGTCCAGCGCCAGCAGCACACAGATACCGGCGTCGATACCGATCGGGAACACCAGGGAGAAACTGCCGAAGCCCTTCTTCTCCGCAAGTTCGCGCACCGCGGCATAAGACCCCGCGAAACCGATACCCGCGATGACGACGGCTCCGGCGACCACGACACCGATGAGTATTCGGTGCGTACGAGTCAGCTGCATCGCGGCCACCCGCGATCCCCTCCCCTAGTCGAGCACAAACCGAGCGCTTACCGCGCCTTTACACAGCCGCGGCAGGCACAGCGTACGGGTGACTCGAAGTCAGCGCCCCAGGAGGCCCCGCCCCGAGATCCGCCGCCGCTCCTACTGGGGCTGGGGGGACTCCGGCTGCGGCTGCTCCGCCGGCTTGTTGGCCGTACCGATCGAGGCCACGGCCTCCTTCGCCGCCGTCAGCGCGTCCTGCAGCAGCTTCGCCTGGTCCGGAGCACCGGCACCCTCGTACGCCGCACCGTTGTAGTCGAGGGTGACCACCACGTTCTGGGAGCGCGCGACCACCGTCGTGTTGAAGAAGTCGACGTCCTTCTTCACCGAGTAGACGACCGACGTGCCCTGGTCGCCCAGGCCCTCGACCGGCTCGGCCTTCACGTTCTGCGCACCCTCGGTGGCCTTCGCCGCCTCGACCTGCTTGCCGTACTGCTCCTCGGCCCGCTTGTTGGCGCTGCCGAGCGACGCGTGCGAATCCGTGCGGAAGAAGGACAGCGACAGCCAGCGGTACTGCGAGCCCTTCAGGCCGTCCTCGTCCAGACCGTTCCAGGAGCAGCTGGCGCGGGTGGCCAGGTCGTTCGACTTGGTCGCCGTGCCGTTCTTGTCCTTCGCCTCCGGCACGAGCGTTTCTATCGTCGCCGTCTGGATCGCCTTGCAGGGATCCGGGAGCGCGGCGAACGCCGCCTTCTCCAGCTCCGGCTTCTTCGCCTTCTCGCCAGGCTTCGAAGAAGCGGACGAACCGGACTTCTTGTCGCCCTTCGAGGCCGAGTCCTTGCCCGAGTCGGAGGAACACCCGGCCACGGTGAGGATCACCGGGACGGCTGCGCAGGCGAGAACGCGGGTGAGGCGCGAGGCTGATCGGTGCATGGTTCCTTCAGTGCTCAGGGGGTCTTCTTCGGACACGGGACCCGGTCAACGGTAGCCCGATCGGGTGCCGGACTGCTGTGCGGGCCGTCACGCCGGAGCGCGGCGCGCACCGCTCACTCGTTGAAGCGGTCGACCAGCGCCAGCGCCAACTGCCGTGCTTTGTCCTGGATTTCGGCGCTCGGCGGGACCGTTCCGGGCAGGGCCGGCTGCACGCTGTACTCGACCTTGACGATGACATTCGAGGTACGGAACACAATCCGCACGGTGCGCGACTGCGCGGCCGTGGCCCCGGCGGGGCTCAGCTTGTCGTCCAGGAAGGCCTCGGTGCCGAGGCCCTCCAGGACGCGCGAGCCGAGCTCGGGCTGGGAGGACGGGCTCGCGCCGGGGGCCGGAGTCCCCGCGGCCGGCGCCCCGGCGGACGGCGCGCCGCTCGCGGGCGGTGCGGCATTCGCGGGCGGTGCGGCATTCGCGGGCGGAGGGGAGGAGGCGGGCGGATTGGCCGGATTGGCCGGATTGGCTGCGCCAGGGCCGGGGGTGGTGGCCGGCCCGGGGAAGGGCAGGTGGGCGTCCGTGAGCAGGCGTACGTAGACCTGCTTGGCCTTGTCGTCGTCGCTGGTGGTGGCCCGGTCGTAGGAGACGACGCGCTCGAAGCCGACCGACAGCAGCCGGGTCTCCTCGGGGGTCTGCGCCGTCCAGCGGCAGCCGACGTGCCGGTCGCCGTCGTAGGAGGAGTCGGCGACGCCGGCGTACAGCTGGTCGAGCTGTTCGGGGGTGAGTCCGTCCGGTTCGGGGAGCATGGCCTTGAGCTTCTTGCTGTCGGCGGCCGCCCGGCAGGGTGCGGGCAGGCTCCGGTACTTGCCCGGCTGGGCGGGTGCGGCGGTGCCGCCGCCGGCCTTCGAGTCGCTGGTACCCGCCCCGTCGCCTCCGCCGGTGCACCCGGTCAGGCCGGCCGCACCGGCCGCGAGCGCGGTGAGCATCGCGATGCCGGGCAGGACTCGCCGTACCGCTTTGCGCTGCACGTCCACTGGCTCCCTTCGACCGGCGGGCCCCCCGACGGTCAGGAAAATGCGTTGCCGCGACTTGGGCGCGGCTGGACACAATGTCTATCGCACACGCTGGTGCTGGCGCCGGTCCCCTGTCGTCTTTGGGATCAAGAGCGAGGCTTTTGCGTAATCTCACCTTTCTGTTGGTTTCGGGGGATTGATCCTTATGTCGTATGTAGAGGTACCGGGGGCGCAGGTCCCGATCCGGATGTGGACGGATCCGGCGTCGGTCGAGGCGGGGGCGATGCAGCAGCTCCACAACGTCGCCACCCTGCCGTGGATCAAGGGTCTGGCCGTCATGCCGGACGTCCACTACGGCAAGGGCGCCACGGTCGGCTCGGTCATCGCCATGAAGGACGCGGTCTGCCCGGCGGCGGTGGGTGTGGACATCGGCTGCGGCATGTCGGCGGTGAAGACGTCCCTGACGGCGAACGACCTCCCGGGCGACCTCTCCAAGCTCCGCTCGAAGATCGAGCAGGCGATCCCGGTGGGGAACGGCATGCACCGAGAGGCGGTGGATCCGGCACGCCTGTACGGGTTCACCGAGGCGGGCTTCGGGGACTTGTGGGAGCGCTTCGACTACGTCGCGGATGCGGTGAAGTTCCGGCGGGATCGCGCGATGCGGCAGATGGGAAGCCTTGGCCAGGGCAATCACTTCTGTGAAGTTTGTATCGATACATCCGGTTCGGTGTGGCTCATGCTGCACTCGGGCTCAAGGAATATCGGCAACGAGCTGGCTGCCTTCCACATCGGCGTTGCCCGCGGGCTGTCCCACAACCAGAACCTCGTCGACCGCGACCTGGCGGTCTTCCTCGCGGCGACGCCCGAGATGGAGGCGTACCGCAACGACCTCTTCTGGGCTCAGGAGTACGCGAAGTACAACCGGGCCGTGATGATGAGCCTGTTCAAGGAGGTCTTCCGCAAGGAGTTCCGCAAGGCCAAGGTCTCCTTCGACCGGGAGATCAGCTGCCACCACAACTACGTGGCGGAGGAGCGGTACGACGGCATGGACCTGCTGGTCACCCGCAAGGGCGCGATCCGCGCCGGCAGCGGTGACTACGGGATCATCCCCGGTTCGATGGGCACCGGCTCGTACATCGTCAAGGGGCTCGGCAACGAGAAGTCCTTCAACTCGGCCTCGCACGGTGCGGGCCGGAAGATGAGCCGGACCGCGGCGAAGAAGAAGTTCTCGGCGCGGGACCTGGCGGAGCAGACCAAGGGCGTCGAGTGCCGTAAGGACTCGGGCGTGGTGGACGAGATCCCGGGTGCGTACAAGTCGATCGAGCAGGTCATCGACCAGCAGACGGACCTCGTCCAGGTGGTGGCCAAGCTCAAGCAGGTCATCTGCGTCAAGGGCTGAGGCCCAAGGCCCGGGCGCGGCTGCAGGGGGAGTGGAGGGGCCCGGACCGATCACGATCGGTCCGGGCCCCTGCATGTGCATCAGCCCGCGGTGCCGTCGAGGAGGAGGCCGACGGGGACATCCAGGGCCGGGGGTCAGAGTTCGCGGTGGACCTTGGTGTTGGAGGCCTGGGCGCGGGGGCGGACCACCAGGAGGTCGATGTTCACGTGGCTGGGGCGGGTCACGGCCCAGGTGACGGTGTCGGCTACGTCGTCGGCGGTGAGGGGTTCCGCGACGCCCTCGTAGACCTTCTCCGCCTTCTCGGCGTCGCCGCGGAAGCGGGTCTTCGCGAACTCGTCGGTCTTGACCATGCCGGGGGCGATCTCGATGACGCGTACGGGCCGGCCGACGATCTCCAGGCGGAGGGTCTCGGCGAGGACGCGGGCGCCGTTCTTGGCGGCGACGTAGCCGGCGCCGCCCTCGTAGGTGGCGTGGCCCGCGGTGGAGGAGAGGACCACGACCGTGCCGTCGCCGGAGGCGGTGAGGGCGGGCAGCAGCGCCTGGGTGACGTTGAGCGTGCCGATGACGTTGACCTCGTACATGGTGCGCCAGTCGGCGGGGTCGCCGGTGGCGACGGGTTCGGCGCCGAGGGCGCCGCCGGCGTTGTTGACGAGGACGTCGCAGCGGTCGAGGGAGGCGGCGAGGGCGTCGACGGCGGCGCGGTCGGTGACGTCGAGCGCGTGGGCGGTCGCGGCGTGGCCGGCCTGGGTGAGCTCGGCGGCGAGGGCTTCGATGCGGTCCTTGCGGCGGGCGGTGAGGACCACGTGGTAGCCGGCCGCGGCGAGCTGCCGGGCGGTGGCCGCGCCGATGCCGCTGCTCGCACCGGTGACTACGGCGGTTCGGGTGGCGGCCGTGCTCATGTGCGGGCTCCTCGGTCGTTCGTACGGGCGATTACCCGCCAGCATAGGCGCGGGCGGCCGGGTCAGCGGCCGCGTGGGGCGTACATGATCACGGCCATTCCGGCGAGGCAGACGAGGGCGCCGACGATGTCCCAGCGGTCGGGGCGGTAGCCGTCGGCGACGGCGCCCCAGGCGAGGGAGCCGGCGACGAAGACGCCTCCGTAGGCGGCGAGGACGCGGGCGAAGTCGCCCTGGGGCTGGAGGGTGGCGGCGAAGCCGTAGAGGCCGAGGGCGATCACGCCGGCGCCGATCCAGGCCCAGCCTCTGTGTTCGCGTACGCCTTGCCAGACGAGCCAGGCGCCGCCGATCTCCAGGAGGGCGGCGAGGGTGAAGAGGGCGATGGAGCGGGCGATCAGCATGGCTCAAAGGTTTGCATGGCAGATGGGGGTGGGCGCGCCCTCGTTCGTGTGATGGTCCGACCGGTGGGGGGTGGTGCGGGGCTAGCCTCCGCGCGAGACGCGAGGAGGTGGTGGCGGTGCGCCGTGTCGCCGTACGGAGTGTGGTGGTGGCGGGGTTGCTGGCGTGCGGGGCGGGAGTGCCCGGTCCGGCGCAGGCGTCGGCGGGGGCTCCGGCGCAGGTGTCGGCGTGGGCGGGGCCGGAGGCCGATGTGTCGTACCACGGCCGGGTCGCCTTGTCGGGGGCGCGGTTGCGGGTGTGGCTGGTTCCGGAGAACGACGGGCCGGCGGCGCTGCCGAACGCGACGCTGCGGGTGCGGCTGTCGGCCGACCTGGCGGACCGGCAGCAGCTGGCGCAGGGCTGTGCGCGGGCGGGTCTGCGTGAGGTGGTGTGCGAGACGGGGCCGCTGCCGTCGCACGGGCGGGGACGGCACGTGGGGTTGGCGCTGGAGCTGCGGGAGCGGGTGCCTGAGGTGGCGGTGCGGGTGGACACCTGGTGGAACGGTGGCGCGACGGACCGGAACCACGCGAACGACGATCACGTGGTGCTGGCCCTGGACACGGGTGACGCCTACGCCTTCTGAGGGCTGTCGCCGCCTTGTCACGCCTTGTCGCCGCCTTCCGGAGCGGGCGTCCGCCCGGGTCGCTCGCGTCAGGCGGTGCCGAATTCGACGAGTGCCTCGTCGACGATCCGCTCCAGGCGGGCGTGGTGGGCGCCGCGCCAGTAGACGCGCTCGCATTCGGTGCACTGGGCGAAGACGTCGTAGGAGCGGTGCGTGCCGTGTTCGAGGCGGTCGCCGACGCTCTCCTTGTCGGCTTCGTGGAGGGGCCCGTTGCAGGCGGTGCAGCGGGTCCACGGGGCGAGGGCGGGGGCGAAGCGGCTGAGGACGTCGCGTAGTTGCTCGTCGGGATTGTCGCTGTAGACGTAGGCGCCGGCGAAGATCTCCCGGCGCCGGAGCAGTCCGCGGTCGCGGGAGAGCAGGACGCGCCGTTCGGCGGCGGAGCGGGTGGCGAGGGCGGGGTCGCCGATGTCCTCGTTCTCGTAGGCGGCGTCGACACCGAGGAGGCGCAGGCGGCGGGCGAGCGTGCCGAGGTGGACGTCGAGGAGGAAGCGGAGGGGGGCGCCGGGGACGTGCTGGGGGCGTTCGACGCCGAGCACCTCGACGTTCTGGCCGTCCTGGGGCACGTAGGAGGTGGCGACCTCCTGGCCGTCGACGAGGAGGCGGCCGACCTCGGTGAGCGGGACCCCGGCGGATTCGACGACGTGGCCGAGGCTGGAGGCGCCGTCGGTGGCGGTCGGTACGCGGTCCGTGCGCCGGCTGGGCGGGGCGAAGAGGCGCAGTTCGGGGGCGAGGGTGAGCTGAATGCCGGGTCCGTTCACCCTGCCAGCATGCCATTGCGGGGTGGGGGGCCGCGCCTGAATTCGGGGCGCCTTACGCGCCTCAGGCGTCGGCGGTGGACCGGTCGTAGGCGGCGCGGTGGGCGTTGACCTCGTCGAAGTGGTTCTCGGCCCACGTCTTCACGGAGGAGAGCAGGCAGCCGAGGCTGCTGCCGAGGTCGGTGAGGCGGTAGTCGACGCGGACGGGGACGGTGGGTGTGACGTGGCGGGTGACGAGGCCGTCGCGTTCGAGGGAGCGCAGGGTCTGGGTGAGCATCTTCTGGCTGACGCCGGGGATCCTGCGGCCGAGGTCGCTGTAGCGCATGGAGCGGTCGTCGGCCTCGCCGAGGGCGCTGACGATGAGGCCGACCCACTTGTCGCTGATGCGGGCGAGGAGCTGGCTGGTCGGGCACTCCCTGAGGAAGGCGTCGTAGGCGGTACGGGCTTCCTCGCGGCGGGCTGCGGCGGTGCTGGTGGCCATGGGTCCCCACTTCCAGGTCCGGTACGCACCTTGGAGTGCGTACTTACGAAAAGAGAGTACCTCTCCCTAGGTTAGTGGTCATCAGAACGGCGCGGGGAGCGCCGGCCGAGAGACGCAGAACGGGGAGAGCGATGAGTGAGCGGACGATGCTGGCGGCCGTGGTGACCGGTTTCGGCGGCCCGGAGCAGGTCGGCCTGGAGCAGGTGCCGGTGCCGCGTCCCGCGGCCGGGCAGGTGCGGATACGGGTCGCCGCGGCGGGGCTCAACCCGGTGGACGGCGCGGTCCGCGCCGGGGTCTTCGGCGGGGCCGGGCAGCGGCTCGGCCTCGGCTGGGACGTGGCGGGGGAGGTCGACGAGACGGGCCCCGGCGTGACCGGCTGGAGCCGCGGTGACCGGGTGGTGGGCCTGCACTACGGCCCGGTGAAGCCGCTGGGCACGCACGCGGAGTACGTGGTGCTCGACGCCGGCGCGGTCGCCGCGGCACCGGCCGCGGTGGACGTGCCGACCGCGGCGGCCCTGCCGCTGGCCGGCCTGACCGCGGCCCGGGCCGTGGACCAGCTGGGGCTCGCGCCCGGCTCGTCCGTGCTGGTCACCGGTGCGGCCGGCGTGGTCGGCGGGCTGGCGGTGCAGCTCGCGGCGCGGGTCGGCCTGGTGGTGACGGCCCTGGCGGGTGCGGGGGACGAGGAGCTCGTACGGTCGCTGGGCGCGGCTGCCTTCGTCCCGCGCGGCGGGGCTCCGGACGGGCCGGTGGACGGGGTCCTGGACGCGGCCGTGCTGGGTGGTGACGCGCTGGCCCACGTCCGTGACGGCGGGGTCTACGTCGGCCTGATCCCGAACCACGCCCCGGCGGCGGAGCGCGGCATCCGCATCGAGGAGCAGGAGGTCGCCGCGGACGGTGAGCTGCTGGCCCGTCTGGTGTCGCTCGTGGACGAGGGTGCGCTGACCCTGCGGGTCGCGGAGGTCTTCCCGCTCGCCGAGGCGGCGAAGGCGCACGAGCGGCTGGCGGTGCCGGGCGTGCGCGGCCGGATCGTCCTGACGCCGTGACGGGGCCGGCGGCCCCACCCGCAGGCGCCGGTGGCGGCTCGGGTGGGGCATGCCGGGCGGGCATGCCCTCGACGTCTCGGTCTCCGGGATCCCCGACCTCGTCACCCGCGATCAGGTGTGCGTCCCATCGCGGCGTCCAGCAGCGGCCGCATCGGGTAGGAGGAGCAGCTTGCCGGTGGTACGCCGAGCCTCCAGATCGCTGTGGGCCCGGGCGGCCTCGGACAATGCGTAGCGGCCCGTCACGGTGACCTCAAGCGCCTTGGAGCGAACCCACTCGAACACATCGGCGGCCCGTCGGAGCAGTTCGGACCGATCGGCGATGAAGTCCCCGAGGCTGGGCCGGATCAGGGTCAGCGAACCGCCGTGGGCGAGCCGCATCGGATCGAACGGAGGCACGGCACCACTTGCCGCGCCGAAGAGCACGAGGTGGCCGCGGGTTCGCAGGCCGGCGAGGCTCGCGTCGAAGGTGTGCGCGCCGACGCCGTCGAAGACAACCGGCAGTCCCTGACCGCCGTTGAGCCGCCTCACCTCGGCTGCGAGATCGTCGACTGCGGAGGGAACGATCACCTCGGCGGCCCCGGCACGCTTCGCCAGCTCGGCCTTCGCCGTGGTCGACGTCGTGCCGATCACCCTGCCGCCGAGGTGGGTGATGAGCTGGGTCAGAAGCAGCCCCATGCCACCGGCAGCCGCATGCACGAGCACCGTGTCGCCCCCCTGAACCGGGTAGGCGTCCTTGACGAGATAGTGCGCGGTCATGCCTTGGAGGAGCACGGCGGCGGCTGTCTCGAAGCCGATGTCGTCGGGCAGCGGCACCAGCCGGGAGGCGTCCACGACGGCCCGCTCGGCATACGAGCCGGGGATCTCCACCCAACCGACCCGGTCCCCGACTGCGACGTCGGTGACGTCGGGTCCGACTTCGACGACCGTGCCGGCGCCCTCGGTGCCCGGGGTGAAGGGCAGCGGGAGGCTGTACCGGCCTTCGCGGTGGTAGACGTCGAGGAAGTTGACCCCGGATGCGGCGACCTCCACGATCGCCTCGCCCGGACCCGGCCGCGGCTGGTCCACCTCGGCCTCCTGCAGCACCTCGGGACCGCCCACTTCGTACACCTGAATCGCTCGCATGGCCCTCCAATGTCGGCTCATCCCCCACCAACCCCGTTGACGGCACTCCGATTCCCGAACCCCCGTACGGAGCTGCCGACGTACGACGGGCTGCGCGCCGCCGAGGCCAAGGGGCAGCAAGGGCGGGCGCCGCCCCGCGGTTGCGGCCACGAAACCGACGGGGTTCCCCGAGGCCGGGCGCCGAGATTTTCTTGCGCATGTTCGTCGGTGGTCCGGGTGGTGCGGATCCGGACAGTGTCCGCCTGGGGTGCTCCGCCGTGCTGCGGGTGCGGCTGACCTGCGCCGGGCCCTTGGCCGGGGTGCGGGGGGCGCGCCGAAATGGAGGGCCGCCAGGCCGGATATCGAACACTGAATGATCAATTCCAAGTGCCAACAATCGCTGTGGCAAAGGGAATTGACCTTTGACTTCCGATCGGCGTGGCCTAGCCTGGCTCTCAGCCGACCGGGGGGAAGGGCTTCGGCTGCCCTGCCCTCTCACTGCATCAGTCACCACCCGACGAGGGGGAGTAACGAGTGCTCAGTAAGAGGATTTCGGCCGGATTCATCGCGATGGCGGCCGTCGCCGGCGTCGTCGCCGCGGCACCGTCCGCATCGGCCGTGGACCGTACCTGCTACGACGGCAATTTCTGCATCTACAAGGACCGGGACTACTCCACCAACAACTCGATGTACCGGACGAAGTACGAGTCCGCGCGCTGGGACATCGACATGCCGGCCGTGTACGAGGCCGACAGCTCCTGGTGGAACCGGCGAGGTCAGTCGTCCAAGACCTACGGCGGTCGCTGGATGTCGCTCGGCGTCGAGATCTGTCTCATTCCCGGTGGTTCCGTGAACTACTACTGGGACGCCAACGACGATGGTGCGAGCAACACGCTGAACGACGGCTCCCGCTGCTGACCATCGCTCGAAGGCCGGGCCGCCCCCGCAGCGCGGGGGCGGCCCGGCCGCACCTTCGGAGGACACGGACATTGAACAAGCGCATCCGGGTTGTGACGGCGATCGCGGTGGCGGCGGTGCTGACGGGCTCCGTCTCCGCCTGCTCGGAGGAGTCCCCCAAGGACATGGAGACGGCCCGCAGGGCCCAGGCCGCGCTCGACAGTGCGAACGAGGCGCTGGAGCAGGAGCGTGAGGCCGAGACCAAGCTGATCCGCAAGTGCATGAACGACCAGGGTTTCAAGGTGTTCCCGTCCGACGGCGCCAACAGCAGCAAGGCCGGCAAGCGCAGCGAAGACCTCACCCCGACGCCCGAGACCGCGCGCACCGTGGGCTACGGCGCCGATCCGCGCCGTTCGGACAACCAGAAGACCCAGGAGGTCGGCGACGACTTCGACGCGCTGCCGGAGGACGTCAAGCGGGCCCACAGCATGGCCATGGACGGCTACGTCGACAAGCCCGAGGGCGGGGTCGAGTTCGACTTCGGCGGTGGCAAGGTCATGGTGCCGTCGAAGGGCTGCCGCGGCGAGACCCTGAAGGCCGTGTACGGGGACGTGAAGGAATACCTGCGGCTCAACTGGACGGTGTACAACACCGTGAAGCAGGACAGTGCGCACATTCTCGCCGACGACGACGCCTATCAGAAGGCATTGTCGGAATGGGCTTCCTGCATGAAGGCCGGTGGTTATCCGGAGATTCCGACTCCCGAGAAGGCCAGGGAGGCGGCGCTTTCGCATTACGCGAATGTCGCGGACGGCGATACAGTCGCCCTCGACAACGCGCAGCGCGCTGAGATCAAACAGGCCACCACTGATGCCGATTGCGGTACGAAGGTCGGGCTCAACACGAAGGCGCGGGAGGCCAAGAGCAAGGCGTCCGCCGATTCGCTGGTGAAGCACGAGGCGGAGATCACCGCCTGGCTGGAACTCGTCACCAAAGCCAAGGGCAGGGCACAGGAACTACTGCGAGAGACGTCGTAACACCGTGATGAGCCTTGAACACCCCGAAGGGGCCCAGGAGGCCGAGCCGTCCGGCGGGCGGGCCCGTCACCGGTCCAGGCGGGGCCTCGTCATCGCCGCCGCCGTCGTGGTGCTGTTCGGAAGTTCCGGATCGGTCTGGTGGATCGCATCCCAGGCCAGAACACCCGAGCAGCGTGCCTCGAACGCCGCCGCGCCCCCGCCTTCGCGGATCACGGGGAAGGTCTCCGACGAGCAGCTCGTCGAGAAGATGGACCTGACCGGGAAGGTCGAGACGGCCTCCCGGACGACCGTCACCGGCACCATGCCGCAGGGCACGAGCCGCGCGGTCGTGACGGGCCTGCCCGCGACGGCGGGCAAGAGCCTGAAGGCCGGTGCGGTCGTCGCCGAGGTGTCGGGCCGCCCGGTGCTGCTCCTGCCGGGCCGCTTCCCCGCGTACCGGGACCTGAGGGCGGGCGACAAGGGCCCCGACGTCCGGCAACTGCAGCGCGCGCTCAAGCCCCTGTACGGGACGGCCGTGAGCGGAACGTACGACCGGGCCACCGTCGAGGCGGTGCGCAGGCTGTACGCGGCGGCCGGGTACGAGGGGCCGTCCGGACAGGGGCAGGGCGGCGGCGCGAGCGGCGGCGGCGCGAGTGCCGGCTCGGCCACCGGCCGGCCCGCCGGCGGCGCCGCCCCCCGCGGCGGCGCGGAGACCGACGGCGGCACGGGCGCGGCCCCCGCCGCGAACGGCGCCCCGAGCGCGGCGCCCGACAGCGGCTCCGACGCGCCGCCCGCCGCCGGACCGGCCAAGCCCGGTGAGACGCTGCCGGCCGCGGAGGTCGCGTACGTCGGCACCCTCCCGGCCACGGTGGTGCAGGTCACCGCGGCGGTGGGCGACGCGGCCGACAAGCCGCTCGTCGTCCTCGGCAGCGGCGGCCGCCAGGTACGGGCGCCCCTCACCGCGGACCAGCGCACCCGCTTACGCGACCTGCCGAACGACGCGGTCATCCGCTTCGGCACCGGCCCCTACGCGGGGCGGGAGGGCAGCCTCGGCTCCCTCACCGGGGTCCCCGACGCCAAGGGCGGCGGCGACCAGCAGGGGAACGCGAAAACGGGCGGGCAGGACGGCGGTGACACGTCCGGCACCGCCGGCACCACAGGTACGGGCACCGCGGGAAGCGGCGGCGGGGCAGGCGGCGGGACACGGCACGAGGCGCTGTTCGTCCCCAGCGGCGCGGAGGCCGAGGAAGGGGCGGTCCAGCAGATCAGCGTCGAGCTGCGGCGCAGCCCCAAGGGCGCGCTGACCGTTCCGGTGTCGGCCGTCTGGACCGACCTCGGCGGCTCGTCCACGGTCACCGTCACCGAGAACGGCAAGGAGCGCAACGTCCCCGTCGAGGTGCTGTTCACCCATGACGGCCTCACCGCCGTCAACGCGATCGACTCGAACCTCGGCGCCGGCCAGAGCGTCGTCCTCGTGCGCCGCGGCAAGGCGGCGGACAGCTCCGACGGGGGCGGCGGCGATGACTGATCCGGCCCCCGTCATCGAGATGGCCGGCATCGCCAAGACGTACCCGGGGCCGCCGCCCGTGCGCGCGCTGACCGACGTCACGCTGACCATCAGGCCCGGCCGGCTCGCCGCCATCGTCGGCCCGTCCGGCTCGGGCAAGTCCACGCTGCTGAGCGTGCTCGGGCTGCTCGACGTACCCACCCGCGGCCGGTACCTGCTGGGTGGAAGGGACACCACCGACCTGTCGGAACGGGCTCGCACCGCCCTGCGGGCCTCGACGCTCGGCTTCGTCTTCCAGGCCTTCCACCTGGTCCCGCACCTGACGTGCGTACAGAACGTGGCCCTTCCGCTCGTCCACCTGGGCGTGCCCCGCGCGGCGCGGCGGCCGCAGGCCGTGGCGGCCCTGGAATCCGTGGGCCTCGGGCACCGGCTGGACGTCAGACCCACCACGCTGTCCGGTGGCGAGCGGCAGCGCGTCGCCGTCGCGCGGGCGATCGTCCACCGGCCGGCCGTCGTGCTGTGCGACGAGCCCACCGGCAACCTCGACACCGCCAACTCGGCCCGCGTCATGGACCTGTTGACAGGACTGGTGGCGCAGGACCGGGCCGTCGTCGTGGTCACGCACGAACCCGACGTGGCGGCCCGCGCCGACCACGTGTTCAAGGTGGTGGACGGCCGTGTTTCGTAGCCGCGGGACGCGTGAGCCGTCCGACGGGGAGACGGGGCGTATGGAGCGGAAGGCGGCCCCCGCCGCTCCGCGGACGTCCGCCGTGGACCTGCTCGTGCAGGCCTTCCTGGCGCTGTTCGGCCGCCGGTTCCGCACCCTGCTGACGATGGTGGGCATCTCCGTGGGGCTGGCCGCGGCACTCGCCACGCTCGGTATCACCGCCAGCGCGGCCGGTGCCGTGTCCGACCAGTTCGACGCACTCAAGGCGACCCGGGTGACGGTCAAGTACCCCTCGGAGCCCGTCGCCGGGATCCGGCCCCGGCCCGACGGCGGCGACACCGAACGGGTCCGGGGCCTCAACGGGGTCCGTACCGCGGGTCTGCTCAGCAAGGCCGGTGAACAGCCGGTGGTCTCCCGCCTGCGGTCGGGCACGTCGAACGACCTGCCCGAGGGCACGGTGCTCGCCGCGCAGCCCGACGCCCTGCTGGCCATGTCGGCCGAACTCACCCAGGGCCGGTGGTTCGACACCGGGCACGATGCGCGGCGGGAGCGGGTGGCCCTCCTCGACACCGCAGCCGCGTCCCGGCTGACCGTCGACGGCGGCGCCGGCAACTCCGTGATCCACCTCAACGGCGTCCCGTTCAGCGTGGTCGGGGTCTTCCGCGCCCCCTCCGGAGACACGAACCTCACCGGTTCCGTCGTCGTCCCCTACTGGGCCGCCCTCCAGGACCCGGCCGGGCTGGGCTTCGCCCCCGCGGAAATGATCATCCGTACGGATCTGGGCGCCGCCGACCAGATCGGCGCCGAAGCCCCCTTCGCCCTGGCCCCGGGCGCCCCGGACAAGCTCGTCGCGCTCGTGCCGCCGGACCCGCGGTCCCTGCGCCAGGGCGTGGAGTCGCAGACCCGGGCGCTGTTCCTGGGACTGGCCGCCGTCTCCCTCGGCGTGGGCGCGCTCGGCGTCAGCAACACCGCCTACGTGTCCGTGCTGGAGCGCCGCTCCGAGATCGGACTGCGCCGTGCCCTCGGCGCCTCCCGGAGGGCGGTCGCCGGGCAGTTCTGCATCGAGAGCGGGCTGGTCGGGCTCGCCGGCGGGGTCGTCGGCACGGTCCTGGGCATCCAGATCACCGCGGTGACGTGCCTGGCCAAGGACTGGCTGGTGGTCCTCGACCCCGCCCTCACGTCGGCGGGGCCGCTGGTGGGCCTCGTGGTGGGGCTGGCCGCAGGGCTGTACCCGGCCCTGGCGGCCGCCCGCATCCTGCCCGCCGAGACGCTTCGGGCGGGCGTGTAGGAGGGGCGGTGCCGCGTCGGCGGTGCTCGTGCTTCAGCCGCGCTGGAAGAACTCCACCTCCGCCAGGGCGAGATGGTGCTGCGGTGCCGAACCGGCGGGCTCCTGGAGGGTCAGCCGGACCGTCGCGACATCGCTGATGCCGGTGGGGAAGGTCTGCGGACCCGGCTTGTCGCTGAGGTGGAGCTCCTTGTGGACCGTGGTGCCGTCCCGGTCCGTCACCTCCATGTCGATCCGCAGCGCCCGGCCCTGCCTCGCGTACTCCTCGGGGGCGGGCGAGGCGCCGTTCGTGACGATCACGGCGACCAGGCGGAACGGCTTGCCGAAGGTGTACGTCGCCGAGGCGCCGGGGCCGGGCGCGGCCCAGTAGCGGTTGCTGAGGCCGTCCGTGCTCTGGCCCACGGGGTGCCCGGGGAGTTCGGCGCCGGCCTGGGCCCGGGTCGGGGTGACGGCCTTGGCCTTGCCGAGCTTGTCCAGGGTGTCCTGCACCAGGTGGCGTCCGGCGGGCAACAGCAGGAACCCGGCCGCGCCGAGCGCCAGTACGACTGCCAGCACCACCAGGAAGCGGACCAGGCGGCCGGAGCCGGCGCGGGTGCGGCGGCGCAGTGGCCAGACGGTGCGCCACCACGGCAGGGGTGCCGCGACGGTGGTGGGCGTCAGCGGTGTCGCACAGCGGCGGCAGAAGCGCCGGTCGGGCGGGTTCGGCGTGCCGCAGGCAGGGCAGGGCGCGCCGGTGACGTTGTCGGCGGCGGGGAGGGGACGGACGACGGGGCGCGGCGCGGCGGCCCTGGCGGGCAGCACCGGAGCCGGGGACGCCGCCGCCGGGTGCACGGGCGGCACCGGTCCGCCCCCGCCCGGGGCCTCCGCCGCCGGCCCGGGGGCCACCGGTCCGGTCCCGCCTGCCCGTTCCGGGCTGAGGGACTGATCCGCCGTGGGGGTGTCCGCCGCCGGCCCGGGGGCGGCCGCGGGTGCGGGTGCGGCCCGGTCCGCCGTGCGGGCTTCCGGGGCGGGCGGGCTCGGCCGCCTGAGCACCCGGGACAGCCACCGGTTCGCGGCGGCGGCCGCGGGCGCGCCGGGCTCCGCCCCGGTGCTCGTGGGGGAGTCGGAGGAGCCGTCCGGCTCCGGGACCTCGCCGCCCTGTGCGTCAGCCTCCCGGGCTGCGGGCCGTTGGGGAGTACCACCGTGCGGACCGCCCTGGGCGGCGGCCGCACCGGGCATACCCTGCCGGGGCGCGTCGCCCGAAGGCGTTGCCTCCTGGGCGGTGCCCCGTCGGGCCGTGGCGCCCGGGGCCGTGGCGCCCGGGGCGGCGGCCGCACGGGCGGCCGCGCCAGGCGCGCCCTGCCGGGGCTCGCCGCCCGAAGGCGTTGCCTCCCGGGTGGTGCCCCGTCGGGCCGTCCCGCCCGCCGTGGGGTCTTCCGGGGGCGCCCCGCCCGGAGCCGTGGCCTCATGGGCGGTGGCTTCTCGGGACGTGCCCTCCGAGGCCGTGTCCTGCCGAGGCGTGCCGGTCTGGGGCGCGGCGGCCCAAGAGGTGGCCCTCTCATGGGTGCCCTGGGGGGCGGCCGCCTCGGCGGTGTCTGCCCGGCGCGTTCCGCCCGGGGCGGCGGGTTCGCCGGGTGTTCCGCCCGGAGGCGTCGCTTCCGGGGCCGTTCCCCGTGGAGCGGTTCCGCCTGGCGTGGCGCCCTCCGGGGCCGGCCGTCCCGGCGTGGGGTCTTCCGGGGGCGCACCGCCGGGAGCCGTGCCCCCATGAGCGGTGTCCTCCTGGGCCGTACCGCCCGCGGCCGTGGCTCCATGGGCGGTGGCATCCCGGGACATGCCTTCCCGGGGCGCGCCCTGCCGAGGGGCGCCGGTCCGGTCCGTGCCGGTCAGGGGCGCGTCGGTCCGAGGGGTGGCCCCCAGGTCCCCCCGCGGCGTGGGCTCCTGGCGGGGCACGCCCGGCCGAGGGGCGTCGCCTTCCGGGAGGTCCGGGAGGTCCGGGGCGGTCCGGGGTGCGCGGCGGGCGGGGGAGGACCAGTTGAGGTACGCGCCGCAGTGGGGGCAGAAGTCGTCTGTCGGGGCGGTGGACGCCCCGCAGGAGGGACACGTGCGCATCGCCGTCAGCTCCCTTCGGCCGTGGGCGGCCCGGGCAGGATCTCCACCCGGCACGCCGTGTGGACGGGGCACAGGCTGTGGACGAGGGCGCGGACCCGGTCCGCGTCCACCTCGTACGCGGCGCCCGGGCCGCGCGGCCACACCCGTACGAGGACTTCGCCGGCCGGTGGCGGGGGCGGCTCGGAGCCGGCCGTGCGGGACCAGACGGCCGTGCCGTCGCCGCTGACGTCGGCGGACACGCCGAGGACCAGGCGCAGGGCCTCGACCAGGCCGCGCCGGGTGCCGCGCCACCGGTGGAGTTCCACCGCGCGGGCCACCGCCTCCCGCCGCAGGGCGGTCGGCCAGTCGGGGTCGTCCGCGGCGCCGACCCAGCCGGCCAGCCAGGCCAGGAAGTCGGCCGGGGCGAGCCGGGGGTCGAAGTAGGAGGGCAGGTTGTCGAGGGTCGTGAACACCGGGGCCAGGACGGTGTCCAGGCCGGCCGTGAACCGCTGGGCGAAGTCGTCGTCGGCGTACAGGGCGGGCAGTTGCCCGCCGATGGGGTGCCGGCTGGGCAGGCCGGGTACGGCGGCCCGGCTCATGCGCCCGCCTCCGGCTCCGTCACGACGACCTGGTGCTGGTAGGAGAAGACGAGCGTGCCCGTGCCGATGTCGACGCGGTCGACGGGGGCGCCGCGCCGTCCCGTGATCGGGTCCGCGGCGAACATCCGGATGTCCTCCACGAGGACGTCCCCGATGGCGCGTTGCAGCACGCCGAACACCTCGCCGTACTGCACGGGCCGCCCGAACGGCCAGCCGGTGCCGTCGGGTCCGCCGTGCAGCGGGTTGAGGTGCCGGTACAGCGCGGCGAGTGCCGCGTCGCGGACCCGGTCGGCGTCCGCGGCGGGTGCCGCCAGCCGGGCGACGACGGTGATGCCCTGGTAGACGGGCGGTTCCACGACGAGGTTGGTGCCGATCAGGCGGCGTTCGCCGAGGGTGTCGGTGATCGCGGTGAGGACCTGGTCGGAGGGGATCAGCTGCTCGAAGCGGAGCCGGTCGCCCTCGTCGGCGACGGCGTCCGGCACGACCAGGACCCGTACCGATCCGGCGCCGCGTCCGCCGTCCGTGGCGGGTAGGCAGCGGACGCGGCGTACGGAGGGTGCCGCCCGCCGGGCGAGGATCTCGTAGTCCTCGGCGGTCACGGCGCGTTCCTGCATGCGCAGGGCTTCCGGGGCGCGCAGCTTGGCGTTGTCGACGGTCTCCCCGGCGACGCCGCCGCGGGCCGCCTCACGGTTGGCGACGCGGGCTACGTACGGGACGGAGCTGCGCAGTACGGAGATCGCGCCGCGGGAGACGTTGCCGGCCGGGCCGCCGCCCGTGCGGTAGCGGGTCACGCGGATCCGGGAGCCCTTGGGCGGTACGGCGCCGCAGGCGCGCAGGGTGCCGTCGGCCTCCCGCAGGACGGGCGGGAAGGAGAACTCGCCCGTGGTGGCGTCGACGCGGACGTGCCGGTCGTCGGGTGCGGAGCGGCCGAAGTGCTCGACGACGTCCCAGCGCTGCCAGCCCGCGGGGGAGGACACCTCCACCACCGGGGGTTCCCCGTCGAGCAGTACGGGCGGCCGGCCGAGGCGGAAGCTCTGCCCGGCCACGCCCTCCGACGCGCCGAGCGGTACGTCGGCCACGCGCTCGGCGTGTTCCACGGTCATGGTGCCGCCGACGGTGAAGACGGAGGCCTCGCGGACGGTGGGGGACTCGGAGTAGAAGGGCTGGCCCGGCTCGGGCTCGGTGACCCGGCAGCGCAGCCAGCCGGCGCGGGTTCCGCCGATCACGGACGCGGTGTGTCCGGCGGGCACGTAGACGATGATCTCGCCGGGCCGGTTGAGGCCGCCGGTGCTGTCGGAGTCGGTGGCGCAGCGCTGCCAGCGGCCGCCGTCCCAGGCCTCCCACACCAGCGGGGGCTGGCGCGGGTCGACGCCGACGCCTTCGACGCGGCTGTCCAGGCGTACGGCGACGACGCAGCGCGGCACGGCTGTCGGGAGGCCGAAGAGCAGGGCGTCACCCGGTTCGGGCGTCGCCTGGAAGCACGGTATGTCGCGGCCTTCGGTGAGGGCGCCGGTCCGGTCGGCGGGTTCGCCCGCGCGGGGCGCGGTGACCAGCCTGGTCAGTTCGCTGGGCAGGATCCGCAGGTCGTCGGTGGTGGCGAAGACGACGGCTTCCCCGGTGTCGCCGGCCGAGGTCGTCACTTCGGTCGCCACCTCGGTGCCCGCGGGCAGGGTGACGGTGTCGGGCTGGGGGGCCGACAGCCAGAAGTCGACGTCGGCGGTGGCCGCCGACGGCGGGTACAGCTGGATGCCCAACAGGTCCAGGAAGGCCAGGTAGTTCTTGTCCGGGACCCGGTTGAGCCGGTACAGGAGCTGGTCGACGAGGTAGGCGAAGGTCTCGATGAGGGTGACGCCCGGGTCGGAGACGTTGTGGTCGGTCCACTCGGGCGCGCGCTGCTGCACGTACCGCTTCGCCTCGTCGACGAGCTGCTGGAACCGTCGGTCGTCCAGGTTGGGGGAGGGCAGGGCCATCAGTCCGCGACCATTTCCTCGGTCCCCTCCTCGGAGGGGATCGTGTAGAAGGGGAAGACCAGGTTGCGCCGGTCGTTGGTGGTGCGCACCGTGTAGTGCACGTCGATGTAGAGGGTTCCCGCCTCGACGGCGTCGAAGGCGACGACGACGTCGTCGACGGTGATCCTCGGCTCCCAGCGCTCCAGGGCCTCGCGGACCTGCTGGGCGACGCGGCCGGCGGTGTCGCCGTCGCCGGGGGCGAAGACGTACTCGTGGATGCCGCAGCCGAAGTCGGGCCGCATGGGGCGTTCGCCGGGGGCGGTGCCGAGGACGAGGCGGATGGCCTCCTCCAGTTCGCGTTCGCGGTCGACCATGGCGATCCCGCCGGTGGGTCCTACGCGCAGCGGGAACGCCCAGCCGCGGCCGATGAACCGTTCGCTCATCACATGCCTCCGATCAGGACGTCCATGGCGCCGGTGAGGACCTGTGCGCCGCATGTGGTCTGGTCGCGGGCCCGGGCGGCGGGCAGTCCCCCGATGAGGACCGTGCCGGAGGTGAGGGCGGCCGGGTTGGGGACGATCACGTTGGCCGGGCCGAGGGCCGCGTGCGGCGGTACGACGCACACGTGCAGGCTGCCGACGACCGCGGCGGGCCGGCCGCCGATCAGCACCGTGGCCACCGCCGCGGCGGCGCCGGGCGGCGGGGTGGCGAGCCGGCCACCGTGGTTGGTGGGGTCGCCGGTACGGGCTGCGGCTGGCATCGGGGGCTCCTCGGGGACGGCGGTCGTGGTGCGAAGGGCGGACGGGCAGGGTCAGTTGATGCGGATCAGGCGGGCCTTGAGGACGGCGAGCAGCCCGCCGTCGACGGTGACGTCGGAGGTGCCGGACACCTTCACCGACCGGCCGCCGATGCGGACCCCGGCGGTGCCGTCGATGTCGACCTGCCGGCCGGAGACCTTCACGGTGCCCTTGCGGGCGTCCAGGGTGATGCCGTCCTTGTCCAGGAGGACGGAGGTCAGCGGCCGGCCCCGGCCCGCGTACACGGTGAGCTCGATGCGGTCCCGGCGGTCGTCCATGCGTACTTCGAGGCGCTCGTCCCCGGTCACCAGCCGCAGCCCGGAGGGGCCCGGGGCCGCCGCGTCCAGCAGTTCCACGCGGTGGCCCGAACGGGACACGATCGAGCGGCGGTTGACCTTGCCGCTGGTCTTGTCGACGAGCGGGACGTCGTGTGGTGAGGGCTGGTCCACGCCGTTGTAGAGGCCGCCGATGACGTACGGGCTGTCGAGCAGGCCCTGTTCGAAGCCGACCAGCACCTCGTCGTTGACCTCGGGGCTGACGACACCGCCGCCGCCCTTGCCGCCCCACTGGACGGTACGTACCCAGTCGGTGGTGTAGGTGTCGTCCAGCCAGGGGAACTTCAGGCGGACGGCACCGCGTTGGGAGCCGTTCGGTTCGCGTACGTCCGTCACCACGCCGATCGCGAGGCCCGGGATGCGCCCGCCGCGCGCGGGCACGCCGGCGCCGGCCACCAGGCCCGTCAGGGAGCGGTCCGGACTGGCGCTGACCCACACGGTGGTGCGGAAGCCGCCGTGCGGCTCCAGGACGTGCTGGACGGCGGTCGCCGTGTACCGGCCGGAGAACGCCTGCCCGACGTTGCCGAGGGCGACCGGCTTGCCGGCACGCAGCAGCGGGTTGCCCTCGGCGACCGCCTCCAGCTCGCCGAAGCCGGAGCTGATCTGCGCGGCGGCCGCCTTCGCGACCGCCGTCGTCTCGGCCTGCGTGCGGTAGGGGGTGTCGGTGACGGCCACGGCGGCCGCCCCGAACCGTGCGGCGGTCTGCGGGCCGAGGCCCGGTACCACCGTGTCGCTGACCACGGACGGCTGCTCGGCGACGAGCGGCCGCTTCGTGGTCACGTCCCAGCCGCGTACCTGCACCTTGGAGGCGCCGTCGGCAGCCGTCAGCGCGGCCCGCAGGGCGAGCAGGTTGCGCCCGTACTCCAGGACCATCGGGTCGCGGACCGCCGACGTCGAGGGGGCGGGCGCCCCGGACGCCTGCACGGGCCGGGTGAACTGGAGCAGGCCCTTGTCGTCGACGCGTACGTGTGCGCCGCTCTCGCCGGCGAGGTACTGCAGGAAGTCCCAGTCGGAGACGTTCGCCTGGGACAGCTGCTTGTAGGTGACCGGCGCGGCCTCCACCTTCCCGACGGCGAGGCCGGCGCCGGCGGCCACCTTGCGGACGATGGCGGCGGCCGTCATGTTCCGGTAGGCCACCACCTTGCGGCCGCGCTGGAGGCGGTGCGCCTTGGAGTAGGCGCGTACGACGGTGAACGAGCCGGTGCGGTCCCGGTCGATCTCCAGAGCAGTGACCTCACCGTTGAACAGCCGCTCCCGGGACTGTCCCTTCACGGTGGCCACCGACACCCGCAGCGGGGTGCCGATGGTGACGCCGGTGGCGCGCAGGAACTCGTGGTCGGGGTCGCGGTAGGTGAGCACCGCGGTGTCGGGCAGGCCCACGTTCTCGTCGACCACGCAACTGACCAGCTGTGCCGCCCAGATCTGCGGCAGTTCGCCGGGGGCTTCCACGATGGGGTCGGCCGCGAAGGACCGCCCGCCGGGCTCGGACCCGCTCACCGCTGTTCCTCCTCGCCGTACTGGTCCCGTACACCCGGTACGACGATCTCGCTGCCGGGGACCAGGGCCATCGGGTCGTCCATGCCGTTGGCCTCGGCGATGACCCGCCAGGCCGTCGCGTCGCCGTACTCGCGCCAGGCCAGCATGGCCAGGCTGTCGCCCGCCACCACGGTGTGCGTGCTGCGGGCGGTGCGTGAGCCGGAGGTCGGGTTCTGGCCGGGCGGGTCGACGCTCGCCTCCTCGATGGACAGCGAGCAGGTGGCCCGCAGCGGCTTGCCGTCCACGTCGAAGAGCGTGTACGACACCGACAGGTTCGACAGGACCCCGTCGAAGGAGGTCGTGCGCGCGCTGCCCCACTCGAAGCGCACCCAGGGGCTCGCCGGCTTCTTGCGGCCGAGGCTGGCCGGGGTCGGCACGCACGCCTTCATCAGCTTCTCCACGGCCTGTTCCACCGAGTTGTCGTGGGTGGCGGTGGCGTCGAGGAACACCTCCAGGCTCAGCGTGCGCGGGCCGCTGCCCACGAACTCGGGCAGCGCCGACTGGCCTGCCATCCGGGACGGGGAGCGCCGCCATTCGGTGGTCTTGCCCAGTTGCAGCGTCGACGGGTTGAACTGCAGGTCGAGCCGGGCGATCGTGCCGCCCGGCTTGGCGCCGACCGAGGCCGGGGGCTCCTTGAGGGTGAGCTGGGCCCGGGCGCGGCTGGCGCGTGATGCCGAGGAGGCCATGCCGTGTCCTTCCTTCCGGGGCGGCGGCGAACGGTACGAGGGGAGGGGGCGGGGGAGAGGGGGCCCGGCGGTCAGGAGCCGGAGGTCGGGAGCCGGGGGTCGGGAACCGGGGTCAGGAGGGCAGCAGGCCCGCGTGGGCGATCTCCAGGGTCTCCACGGCCGCCGCGGAGTTGGCGGGGTCGAAGGACGGCCCCTGCCAGCGCACCGGGACGATCCCGAAGACCTGCCAGCTGATGATCCGGCTGAGGTCGGGCCGTAGCGCCACGATCTCGCCGTCCTTCGGCTCGACCCGTCGCAGCGTCTCGTCCAGCCAGCGGCCGATCTTCGCCGTGTCGGCGGTGACGGGCCGGGTGAGGGTGATGTTCGACCAGGTCACGCGGCCGGGCAGCTGCCACGTGAAGCCGTTGTTGCCGCCCTCGGCATAGCTCTCCATCTCGACCTCGGCGCCCATCCCCGAACAGGTGTGGAAGGCGCCCAGGTCGTCGCCGCCGATCGCCAGCCGGAAGAACACGCTGGTCGCGAAGATGTTGTCCGTCATCGGTCCGTCGTCCGTTTCTCGTTCGTACGTGGTCTCAGCGGCGGCCGTCGAAGGGCCTGCCCGCGCGTTCCCGGCCGCGCCGCAGCTCGGTGCGCAGGAGGCGGGCGACCGGGTCCAGCAGACGGCGCGCCAGGTCGTCCAGGTCGAGGTCGGCGCCGCCGGACGCGGCCGCGTCGCGCGCACCGTCCGGCCGGCCGGCCGTGGTCCCGCCGGGGTGGGCGCGGGCCGGGCCGAGCGGGCCGGAGCCGGTCCGGCCGCCACCCGTGTCCCGCTGCACCGGGGGCGGCGGGGCGGTCGGAGGCAGGGGTACGGGGACGGGTGCCTGCGGGGAGGCGGCCGGGGCCGAGGACCGGGGCCGTACGACGGGCACGGATCCGGCGACCGGAGCGGCGGGCGCCGGCTGGACCACCAGCGGGGACGTGTACGGACCGGTCACCGGCAGGGGGGTTGCGGTGGCGCGGGCCGCGGCGGCGGGCGCCGGCCGTACGGCGTGCGCGGCGTGCACGGCGTGGGCGGGACGGGGGCCGGGGCCCGGCGCGGGGGTGCGGGCGGCGGGTGCCGAGGCCCGCTGTACCGGCTGCTGCGGTGCCGCGGCGGACGCGGCGGACGCGGCGGACGGGGCGGACGGGGTGGCCCAGCGCGCCGGGACCACGGGGCGGCTCGCCGGACGGGGTGCGGCGGCGGGTGCGCTCCCCATGCCGGCCGCGTCCTGGGTGCCGAGGGTGAGAGGGCGCGCCGCCAGCAGCTGGAGGGACGCGGGCGCCCCACGGGCCGCGCCCGCCCCGGCGACGGCGCGGGCGGCGACGAGCGGGACCGGACCGGAACGCCGCGGAGAGGCGGTGGCCCGCTGCACGGGCGGCCGCGCCCCGGCAGGCCCCTTGGCGGCCGACGGCGCGGTGGGCGCGGCGGGTACGGCGGCACGCGCGGGCATCGACGGCAGGGGCGCCCCGAGTCCGCTGCGCACGCGCGGCCCGCTCGGCGGGTTCGCCGGTACGGCGGTGGGCGGGAGCTGGGTGAGGGGTTCGCCGAGGGGCGCGCGGGTGCGCATCCGCTGGGCGGGCGCCGCTGCTGCCGGGGCGCTGCTCGGGGCGGGGTCCGCCGGGCGTTGGGCGGTGGGCAGGGCGGCCGGGGCCGGTGTCGCCGCCGGGGCGGGAGTCACCGGTGCGGCGGTGGGAGGGAGTTGGGTGAGGGGTTCGCCGAGGGGTGCGCGGGTGCGCATCCGCTGGGCGGCTGCCGGTGCCGGCGGGGTTTCGGTGTGCGGCGCGGGGGTGCGCTGTGCCGGCGACCCCGGAGTCGGCGCGGTGGCCGCGGGTTCCGTGTGCCGCTGCACGTGCGGCAGGGCCGGGGCCGGGGCGGGAGTCACCGGTGCGGCGGTGGGAGGGAGTTGGGTGAGGGGTTCGCCGAGGGGTGCGCGGGTGCGCATCCGCTGGGCGGCTGCCGGTGCCGGCGGGGTTTCGGTGTGCGGCGCGGGGGTGCGCTGTGCCGGGGACCCCGGAGTGGGCGCGGTGGCCGCGGGTTCCGTGTGCCGCTGCACCTGCGGCAGGGCCGGCGCCGGGGTGGCCGCCGGGGCGCTCGCGGTGGGGTCCGCCTGGCGCTGCACGGTCGGCAGGGCCGGGGCCGGGGTGGCCGCGGTGGGGGTCGGCGGAGTGACTGCCGACGGGGTGCGGTCGTGCGGCGTGGGCGGAGCTTCGCCGAGGGGAGCGCGGGTCCGCATCCGCTGCGCGGGCGGCTCGGCAGGAGCCGGGCTCGGCGGCGCGGTGAGCGGCGAGCCGGTGCGCTGGAGCGGCGCGTCCGCGGCGGCCGGGGCCGCCCCTGAGGGTTCCGCCTGCCGCTGCACCGTGGGCATGGCCGGTGCCGGAGGCGTCGCGACAGGGCTCGACGGCGGTTCGGCGGGCGGGAGTTCGGGCAGCGGGCTGCCGAGCGGGGCCCGGGTCCGGGCGCGCTGCACGGACGCGTCCGGGAGGACGGTGTCAGGGGCGGCGCTGGGGGCGGTGCCCGGCGTGGCGGAGGGGCGTACGGCGGGCACGTGGCGCCGGGGCGCGGCGGGGACCCGCGCGGTGGTGAGTGTCCGGCCGACCGGGCGCGGCCGGACCGTCGTGGCCGCGCCCTCGCCCGTACGCCCGGCCTGTGCCTGCGTACGGGCGGCAGTGCGCTGGACCGGTGCGCCGGCCGGGCCCTCGGCGGATGCCCCGGGGACCACCGCGATACGGCGGACCACGGGGAAGGACGCGGGCGTGGGCGCGGTGCGGCCGGTCTGGGCAGAGGGGGCTGTGGCCCGCTGTACGGCGGGTGCGGACGCCCCGAGCGCGGCCGCGGAGCGGGTGGCCGCGAGGTCCCGCGTACCGGACGCTGCCGACGGCCGACCCGGCGCCGCGGCGCCGCGAGCCACGGACGCGGCGGTGCCGGATGTGGACGGGGTCTCCGGATCCGGCGACGTTACGGGCCGGCCCGGGCGTGACGCGGGCGGGCCGGCGTCGGGGCGGGCGACGGCGCGCGAGACGACGGGACCCGGTGCGCCGCTGTTCGCGTCGTGGCCCGCGGCCGGGGTCGGCCGTACGGCGTCCGGGGCGGACGCCGGCGGGCTCGGCGAGGCCGCGCCGGGGCGCGTACGGCGCGAGATGTGCGGCGGGTGCTGGGCGTGCCGCGTGTCGCGTGCCGGTGCCGGCCCGTGCCCGGCCCCGGGCTCCGGTTCCGCGCCGGGCGCGGTGGGCAGCGCCCGCAGCAGCAGCGGGCCGCCGCCGCTGTGGGTGGGGCGGGCGGTGGCGGGGCCGGCGACCCCGCGGACGAGACCGGCCGGGGCGGACGGCAGCAGGCCGTGGCCGAGCCCGGTGTCGAACGACGGGTCGCGCCACGCGGCCAGGCCGGATCGGAAGGCGAGCCCGTCGCTGACGCCGGCGGCCGACCGCGAGACGGTCAGCGCGGGTGGCGCGGTCATCCGCCAGCCGCCGTCCCAGTCACCGGGTACGGCGGCCGGCACACCGGCGCCGGCGGCCCCGCCGGCGTCCGGGGCCGTCACCGCGGCCGCCGACGCCCCGGGGTCCGGCACGGCGGCGCGCCGGCGCAGCCTGTCCCGCCATGCCATCTGCTCAACCGCCTTCGTTCACACGGGTGTTGATACGAGCTATCTCGGTGACCCAGTCCTGCCGCTCGCCGTGGGTCAGGTCGAGGATCTCGTCGCGCCGCCAGTGGAAGTGGTAGGCGATGTACGCGATCTCCTCCCGGAGCCGGGGGAGCGCGTACGTCACGATTCCCCCAGGCGCCCACCGGAGAGGTCGACCTCGAAGCCGCCGTCGCAGTGCGGGCAGGTGACCGCCGCGCGGGTGTGGCCCTCGCTGTTGACCCGCCGGTAGAAGTCCTGGAGGAACGCCACGTCGGTCGCGTACATCCGCTCGACGATCCCGGCGTGCACGTCGGTGACGGTGCCGAGCCGGGTGATCACCTGGCTCAGCAGCACCACGCTCAGGTACGCCGGGTTCTCCTTGACCCGCAGGTCGATCTGCGGGCGGAGCTCGTCGCGCGCGGTGGCCAGGCGCATCGCGCCGTGCCGGTGCACCGTGCCCGCGTCGTCCACGTAGCCGCGCGGCAGCTCGAACTCGAACTCCGTGCGCAGCCCGTGGTCCTCACGGGGGGCCGGAGCGGCGGCGGCCGGGGGAACCGCCGCCTGCTCCGGGGTCTGGGCGGGCGCCGTGACCTGGAGGATCTCCTCCAGGCTGCCCGCGGTCACGGTACGGCGCCTCATTCGACGATGATCTCCTCGAACACGATGGTCACGGACTCGGTGGCCGCGGCGGACTCGCCGGCCTTGAGGGAGGGGCCCTCCCACTTGGAGGCCCAGCCCTGCATCAGCTGGATGCGGCGGATGGTCGCGCCCGTGGAGTCCTTGATCTCGATCGTGAGGTTCTGCCGTGCGGTGTCGACGGCGCCGTTGTTGAGGGTTTCCTTGATCCACTTGGTGAACTCGCTGCTCTTGTCGAGTCCCCGGGTGATCGTGACCTCGCCCGCCTGGCGTGCGCCGGGCTGCTTGCGGATGATCTGCTTGCCCTCCGCGCTGACCTGGCGGACCTCGACGACCTCTTCCTCGACGGTCAGGCCGCTGATCTCCTGGATCGACTCGACCAGGTAGCCGCCGAGCTGCACGCCGAAGATATGGGTGGAAAGAGCATCGCCCTCTGCCATGACTGTTCTTCACCTTTCCTTGCTGCTGCGCTGCTTCTGGTCCGGCCGGCGCCGGCGCCCGTGCCCGTCTCCGTGTCCCGGACGGTCACTCGTCGACGAGGCTGGTGCTGTCGGAGAACTGCGCCAGCCGGAACACCACGAACTCGGCCGGCTTGACGGGCGACACGCCGATCTCGCAGACGACCCGGCCCTGGTCGATCGACTCCTGCGGGTTGTTGTCGCGGTCGCACTTGACGTAGAACGCCTCCGCCGCCGTCCGGCCGAACAGGGCGCCACGGCGCCACTCCTCCGTCAGGAACGCGGTGACGTTGCGCCGGATGCTGGACCAGAGCCGGTCGTCGTTCGGCTCGAAGACCACCCACTGGGTGCCCAGGAGGATGGACTCCTCCAGGTAGTTGAAGAGGCGGCGCACGTTCAGGTAGCGCCACGCCGGGTCGGAGGAGAGGGTGCGCGCGCCCCAGATCCGGATGCCGCGGCCGGGGAAGGCCCGTACGCAGTTCACACCGATCGGGTTGAGCAGGTCCTGCTCGCCCTTGCTCAGCCGCAGCTCCAGGTCCACCGCGCCGCGGATCACCTCGTTGGCGGGAGCCTTGTGCACACCGCGCTCGGCGTCGCTGCGCGCCCACACGCCGGCGATGTGGCCGCTCGGCGGGACGGTCGTGTTGCGGCCGGCGGCCGGGTCGAAGACCCGCACCCACGGGTAGTAGAGGGTGGCGTAGCGGGAGTCGTAGCCCGCCTCGTCGTTGCGCCAGGTCCGCACCTGCTGGGCGGTCAGGCCCGGCGGGGTGTCGAGGACGGCCACCCGGTCGCCCATCTGCTCGCAGTGGGAGATCACGGCGAGCTGTACGGTGCGCACGCCCTCGGAGTCGATGTCGCCGCGCTCGTAGGCGCTCATCAGGTCGGGAACCGCGACCATGGTGATCTCGTCGATGGTCTCCAGGCCGGCGAAGCCGGTCCGGGCGCCCGCGTCGCCGACGTACTCGGCCGGGTCCAGCCGGGACACGGCCGTACCGCCGGTCGCGGCGGGTACGGCGGGCAGGGCGTCGGGCACGGCCAGGCTCTGGACGGCCGGCCGGGTCTGGGCGGCGGACCGCTGCTCCGTGACCTCGATCAGCTTGGAGGCGCGGGCCTGGGTGACGAGGTAGCCCTTGACGTTCTTGCGGGCGGAGGCCTCGAAGGTCTCCGCGACCTGCTCGCCCTGGCGGACCAGGAGCTTGAAGCGGTCCTCCGGCGGGTTCTCCCCGTCCGCGTCGGCGATCTCCACGGACACGCCGGTGACGCCCGGACGCGCCGTGATCAGGAAGCCCCCGAGCTCGACGGGCTCCGCCGCGCGGGGCGGGGGGACCGCGCCCGCGGCGGCCGGCCCGGCGGAGGCGCCGGCGCGGTCGGATCCGCCGACGCGGACGACGTACGCGGCGCCACCGCCGTTGGCGAAGTAGCCGTAGACGGCGTGGGGCAGGTAGGCGCCCTCGGTGAAGCCGCCGAAGTGCTGCGAGTACTGGTCCCAGCTGGTGACCAGCGTCGGTTCGTGGAAGGGCCCGCTCTGGGCGAACCCGACGAACGCGGCGACGGCGGTGCCGACCCCTTCGATCGGGCGAGCACCGGACTGCACCTCCTCCACGTACACGCCCGGGGTGAGGTACGTCGGCATGCTCGCTCCTTCGTCACGGCTGACAATCAGGTCCGGTCACAGCCTCGTGCGCGGGCGACGCCGCCGGCAGGGGCGTGCGGACCTGGTCAGGGGCAAGTGCGCTGCCCTCGTGGTCGTTCCGGCCGGGCCGGCCAGGCAGCGCCCCCACCCCCCGCGCACCCCGTCCGATGGCCGCCGGCACGCCCCGGCATGCCCCGGGCGGGGCTCACACGTCCGTGACCTGGCCCAGGTACGGTCCGAACTCGCCCTCCAGGACCAGGCGGCCGAGCTTGCGGTACTCCTGGGCGACGGCGGTCACCACCTGGCGCATGGTCAGGGGCCCGTCCGACGCGGCCGCGAAGTAGGCGGCCGTCACCGCGCAGGACCGGATCGAGCCGCCGGCCAGATCGAACCGGGTGGCGCAGAAGCCGAGATCGACGTCGTCGGCCCGGGGCAGCCGGTCGCCCAGGCAGCGTTCCCACAGGGCCCGGCGCTGGGCGGCGTCCGGCACCGGGAAATCGGCGATCACGTCGAGGCGGCGGGTGAACGCCTCGTCGAGGTTGGCCCGCAGGTTGGTGGTCAGGACGGCGATGCCGTCGAAGGACTCCATCCGCTGGAGCAGGTAGGCCGACTCCATGTTGGCGTGCTTGTCGTGGGAGTCCTTCACGTCCGAGCGCTTGCCGAAGATCGCGTCGGCCTCGTCGAAGAGCAGCACCGCGTTGACCGCCGAGGCCTCCGTGAAGATCCGTTCGAGGTTCTTCTCGGTCTCGCCGACGTACTTGTCGACGACCGTGGACAGGTCCACCACGTACAGGTCCATGCCCAGGTCGGCGGCCACCACCTCGGCGGACATGGTCTTGCCGGTGCCGGAGGAGCCCGCGAACAGGGCGATCACCCCGCGGCCCCGGCCGCCGCCGGGGCGCATGCCCCACCGGCCGAGGACCTGGTCGCGGTGGCGTGCGCGCACCGCGAGCTCGCGCAGCCTGCGGTGGGTGGGAGCGGGCAGCACCAGGTCGTCCCAGCCGACGGCGGGCTCCACCCGGCGGGCGAGGCGGGCCAGGCCCGCGCCGTTCTGCGCCCGTACGGCGGCGCGCAGGTCCGCGGGGGAGACGGGCCGGCCGTCGAGCGCGGCGGTGCGCGACGCCGTGTCGGCGGCGCGTCGCAGCTGCCCGGCGTCGAGGCGGTGTGCGGACACCGACCGGGCGAGCATGTCCGCCCCGCCTCCCTCTCCGTGGTTCCCGTGCTCGGCGGCGGCCCGTTCCAGTGCGTGCCGCCAGCGCACGGCCTGCCGGTCGGGGGAGGGGGCGGCCACCGTCAGGGAGACGGGGGTGGCGGGTGCCCAGGCCGGCTCCCAGCCGCTCGCGCCGTGCGTGAACAGGGGGATGCCGCTCAGTGCCGTGCACAGTGTGCGCAGTACGTGCGCCCGTTCACCGGGATGGTCGGGCAGCTCCTCCAGCGGCCCGAGCAGCACACCGGCGCCCAGCAGCCGCGCCTCGCGGGCCGCGGCGCGGGCGAGTGCGGGCAGGGCGCGGGCGTGGCGGGTCAGCGCCGACGGGTCCAGGACCAGGGGGTGCAGCCCGCGGGCCCGCAGTGCGGCGGCGGCCAGCCCCTCGGGGTCGCCGCCACGGGCGCGCAGGTGGACGTGGCCGGTGCCGCCGGCGGCCGCGGCGGCGGCCCGGTGCAGTTCCTCGGGGTCGACAGCCGGGTCGTCGGCGGCCTCGCCGAGCACCTCGGCCAGCTGGGGATCGGGCGCGCGGTCGCCGAGCAGGTGGGCGGTGACCCGGTCCGGTACGGCCAGCACCCGCGACAGGGGCGGCCGTTCGGGTTCGGTGACCTCCAGCAGGCCGCCCGCGACGAGCGGTGCGCCGGGCGCGAGCCGGAACCGTGCGGCGGGCGCCTGGCCGAGGCCGCACAGTTCCAGGGCGAGCCCGACGGTGGGCCGGCGGCGCGTCAGGTCGTCGTTGAGGTAGCCGTAGAGCCGTTCGAACCGGGCGTCCAGGTCCGGGGCGAGCGCCACCAGCAGCAGGTCCACGTCCGGCGGCTCCAGGCCGAAGCGCGTGGCGAGCACGTCGAGCGGTGAACCGGGCGGCGGCGGGCCGGCCGCGGCGAGCGCGGGCAGGTCGGCGGCCGGTTCCCCGTCCAGGAGCCGGTCGACCGCCTCGGGCGTGAGGTACTGGCCGCGGTAGGGGTCGTCCGGGTCGGGGTCGGCGGCGCGCCGCAGCCGCACGGCCAGCCGGACCCGTTCCTCGACGAGGCGGAGCCGCGTCCACAGGTAGGGGAGTTCGCCGTCGGCGGTCCCGTCCCGGTCCGGGCCGGCGGCCTGCTCCGGGGCCGGGGGGTGCAGGGTGTGCGTCACGGCTGGCGTTCTCCTCGTCGCCGGCGGGCGGGGGCACCGGGCCGTTCCCGGGACCCGCCGAAGCCTTCCGGCCCGGTCGCGCCGAGCTCGACGTAGCGCAGCCGGCGCGGACTCCCGCCGGCGTCCCCGTCCGGCTGGGCCTGCGGTACGGAGTCCACCACCAGGCCCTGGGTGACCGGCTGGGCGGTGACCCTGTCGATGCCGGCCAGCGGTGCCTTCACGCGCAGCCCGAGGGACGGCTTGAGTTCGCCGCCGAGCGCCGACCACACGTCGGAGGCGGCCGGCGCGTCCATCCCGGTGCCGCCCGCGTCGACGTCCACGAGCAGGCCGAGGTCGGCGAGGGTGCCGGTGAGCAGGCGCGGCGGCAGCGTGTCGGTGCTCACCAGGCAGGCGAGGACCTGCGACAGCAGCCGGTGCTCGTCCTGCGGCCGTCCCGCCCAGGCGGTGACCAGGTACGTCAGCTCGAACCAGCGCGGCGGTGTGCGGCGCGCGACGACGAAGCCGTCGGCGTCGTACACCACGCCCGTGCCGCTGCCGCGCCGGGTCGGGTCCTCCCGGATGTCGTACAGGAACACGCAGACGGTGGGGGCGCTGCGGCGGGCCGCCCAGTCCCGGGTCGGCGCGTCGAAGACGACCTCGACGCCCGACGCCTCCAGGCCCGACTCCGCCAGCAGCCGGCGCAGTCCTTCGTCGACCTCGTGGATCACCGGCGGGCCACCTCGTCGGGCGGCTGCACCGTGCCGTTGACCACGAGGAAGTCGGTCTGCACCGGGGAGAAGCCGGGACCGCTCGCGGTGATGACGCGGGGGCCGGTCTGGTCCTTGGCGAGGATCAGCAGCTGGCCGATGAAGGTGCCGTCCGCCTGGGGCACGGTCGGTGCGGCCGCCGCGGTGATGCCCGGCTTCCACGCGAACCGCACCGGCGTGCCGGGCGGGAAGTCCTCGCCGCGTACCGAGGTGACGAAGCCGGGCCTGCCGATCGGCGGGACCGCGACGATACGCGGCTGGAGGATGCGCAGCTGCTGCCGGGCGGTGTTGTCGCCCGGGTCGGCGTCCGTGCCGGTGGTGGTGAGGGTCGCGGTGATCTCGGCGGTGAGCGCCTTGTCGGGGCTGAGGACGACCCGCAGGACGGTGCGGGCGCCCGGCGCCAGATCCGGCAGTGCGCACGTCCAGTTCCGGTCGCAGCCCGGCGGCGGCCCGTCGTGGGGGACGCCGCCGGGCAGGCCGATGCGCAGCCGCAGGCCGGTGGCCAGGGCGCTGCGGCCGTTGGCGACGGTGTACGTGGCGACGACGCGGCCGCCGACGTAGCCGGGGTTGGGCTGCGCGGTGATGCTCACGCCGGGGCCGGCCTCGGGTACGGGCGGCTGCGCGGGCGGGGCCGTCGGGGTCGTCGGGGTGGGCGTCGGCGCGGGGCCGGGCGGGGGCGTCGGCGCCGGGGTGGGCATCGGCGTGGGTGTCGGCTTCGGGGGTACGGGGACCTCCCGCACCGGCACCACCGTCCGGCCGGCGTTGTCGCTGGGGCGGGGGTCGAGGACGGTGCCGGTGACCGACCACTCCACGGGCTGCTCGCCGGGGACGACGCCGGTGAGGGTGGCCGTCACAGGGACGGTGGCGCCGGGGCGGACCACGCCCAGGGTGCAGGTCAGGGCGGCGGCGTCGCAGGCTGCGCCGGGGGCGGTGAGCGCGGTGACGCTCACGCCGAGCGGCGGTGCGACGGTCAGCCGGGTGCCGGGGGACGCCGCCGGGCCGTGGTTGACGACGTCCACCCGGACGGTGGCCGAGCCGCCGACGGTGAGCGGCGGGGCCTTCTCGGGCGCCCGCACCGCGAGGTCCACCGACTGCTGCACGGCGGGCTCCTTCTGACGCCCCGGCAGGCCGGTGACGAGCAGGTTGTGCGCGCCGGTCGCCACGTTGACCAGCTTCAGCTTCTCCGGGCTGTTGACGGCCCGGTCGCCGCGGCCGGTGAGGACGAGGGACTTGCCGTCGGCGGTCCAGGCGGCGTCACGGGGCTGGTAGGGGCCGTTGCCGGTGGTCTCGGGCAGTTCGCGGCCGCAGGCCCCCGGCTTGTCGCGGGCGGCGTCGGGCAGCAGCACCCGGCAGGTGCCGCCCGTCGCGGCGGCCAGCAGGATCCCGCCGCGCTCGTCGACGCGGCCGCCGCCGCTCTTGCGGTTGAAGGCGATGGTGGCGCCGTCCGGGGAGAACGCCGGGCTGTCGTCGATGACGTCGCAGGCGCCGGGGCACATGGTGGCGCTCAGGTCGCGCTGCCGGTCGAGGTGGTCCACGGGCACGGTCCAGACGTGCTTGTTGCCGCCGTGGCCGTTGATCACCAGGTTGCGGGTGAAGGCGAGGGTCGTGCCGTCGGAGGACCACGTGGGCTGGGCGTCCCCGCCCCGCGGATGGCCTTCGGGCGGGGTGACCTCGCTGCGGATCGCGCCGGTGGCGGCGTCCGCGATCAGGATGCGGGCGGGGCCCGCGGCCTCGCCGACGCCGCCGGGCGAGGTGCGCGTGAAGGCGAGGTACCGGCCGTCGGGTGAGAACGCGGGGTCGGTGTCCCAGTCGCGGGGGCCGCGGCCGGCGAGCGGCAGGACCGAGGCGTTGGACCCGTCGGCGTCGGCCGTCCAGATCCGCTGGATCCGGGCCCCGGGATCGCCCTCGAAGCGGGTCACCACGATCCGGCGCCCGTCGGGCGTGTAGCTCTGCCGCTCCGTCCACGGGTCGTGCCCGGGCCCGGGCCGGAACAGCGGGTCCCTGGCCGGGTCGGTGTTGGTGTCGGCCTCGGGGTCCTCGTCGAGGATGGTCAAGCCGAGGTCGCGCGGGTCGGAGCCGTCCGTCCGGGCGTCCTGCAGGGTCACGGCGTGCGGGCCGGCCGCCGAAATCCGCTCGACGACGGCGCCGCCGCCGTCGAGGGGGCCGAGCCAGGTGGGCGAGCCGATCTCGCGGTTTTCGCTGTAGACCAGTTTCGGGGTGTCCGCCGAGTGCGCGGCCACCTGGAAGACGTGGTCCCAGTCGCCCTTGCCGTCGCAGGTGCGGTCCGGGCTGAGGAAGAGCAGACCGTTCCCGTCGGGCAGCCAGGCTGCCCCCCGGGTGCGCCAGCCGGCCTGGGCGCCGGCCAGCAGCTCCCCGTCGGCGCGGCCGTTCGTCCAGCGCAGGCGGGGGCCGGAGCCGCCGGTTGCGGTGTAGGCGATCACGTCGCGGTTCGCGGCGTCGTCGACCGGGTTCCACACCGGCTCGGTGGCCCGCCCGTTGGCCGGGTCGGTGAGCCGGGTGGCCGCGCCGCCGCGCAGGGGGCGTACGTAGACCTGCCGGCCGGCGGCCCGGTCGCCGTCGGAGGAGTACGCCAGGCGTCCGCCCTCCGGGGAGACGGTGGGGTGCTCCTCGTTCGCGGGGGTGTCGGTCAGCCGGGTCAGGCCGGTGCCGTCGGTGCGTACGAGCCACAGGTCGCGCTGGACGCCGCCGGTCGCCGCGCGCTGGGCCGAGTCGAAGACGACCGCCCGCCCGTCGGGGGTCAGCCGCGGGTTGGCGGCGTCCATGCCTCTGGTCAGCCGGCGTACCGAGCCGTCGGCGGACCGCAGGTAGACCTGCGGGGCCCGCTCGTCGCGCCGGCTGGCGAAGACGAGCCGGTCGCCCAGCGCGGCGGGCTGGACGTCGAGGTGGACCGGTCCGTCACCGAAGAGCGGGGTACTGGTGTCGGACTTGCCGCTCACCACCCGCCCGAGGCTGCGGTGGCGCGTACCGGCGTACGCGACCCGGCTCTCGCCCGCGTCGGCCGCGCCGGACGCGAGGGGGCGGGCCCCGGCGTCGTCCGGTCCGGCTGCCGCCGTCACCGCGAGCAGGGGCGCCAGCAGCAGCATCGACGCGCCGGCCCTCCCCCAGCGGTGTCGCCGGCGGCCGGACCCATCCGTGCCCCTCACGGCCCACCTCACAGTCCGGTCCCGCGTGCTGCCTGTCACCCCGCCACCCTGCGGGCGGGCGCCGCGCGTGCGACAGGGCCGCGGGGCCGGATGCGGGGGAAGCGCGCGTTGCGCTTTCGGGCAGTGGCGGGCGTCCCGCCCCGCCCGCCCGCCGCTGCCCTGCGGCCCGCCGGGCGGGCGGGCGGTCAGATCAGCCCGTTGCGCAGGGCGTAGCCGACCGCGTGTGTCCGGTTGCGCAGCTGGAGGCGGGTGATGACCTCGTGCAGCACGTTCTTGACGGTCCGTTCGGAGTAGGACGTCTTGCGGGCGATCTCCGCCGTGTCCAGGCCCTCCGACACCAGGCGCAGCATGTCCGCCTCGCGGGCGGTCAGGGTGGACAGGGACACCGAGCGAGGATCGAGCGCCGAACGCTGCAGGCTGCCCACGTGGTCGAGGAGCTTCGCGAGGAGGTCGCCGGGCAGGACGCCCTCGCCGTTCGCTATCGCCAGGACCAGCCGCAGCAGCCGGTCCTGGTCGGCCTCGGCGCGCCGCAGCACCGCGCTGACACCGCATTCGATGGCGCGCTGCAGTGCGTCCCCGGATTCGAAGGTGCCGACCACGAGCCCGGTGCGGGTGTCGGGGTTGTGCCGCAGCCGGTACAGCAGGGCGGCCGTCTCGTCGTCGACGCTGTCCACGGTCACCAGCGACACCTGCGCGGTGTCGGCGTCCAGGTCGGGGACGAGTTCTATCTCGGGGCGCTGGCGCAGCTGGTGGACGACCCCGACGCGCAGGATCGGGTCCGACGCGTACACGGCCACGGTCACCCTTCGGCCGGTTCTGCGGGGTACGGCGGGCGCGGGGGCGGGGGCCGGTGCGTGCGGCCGGGGCGCGTGGGCGGGGGACGTCGGGACGGGGCTGTTGGTGTCAGCGCAGCGCATGTGTCGTACCTGTTCCGTGATGCGTGTGTGGGGTGACGGAAGGGACCGGCCTGTGCGGATCTCGACGCTGAGACCCAACCGGTGGTCGTACGTGAGGAGTTGGAGAGCCCGTGGGGGCATCGGGACTGCCCGGGGCCTTGCCCCCGCGTCCGTGGGGGAGGGGGCGGTGCCGGCGTAGCGTCGCGGCGTGACATCCCCAGCCGCATCTCCCAGCCCTGGCGCGCCCGTCCTCGACATCGAGCCGGTGTCGGTGATGCCGGGCGGTACCGCCACCACCAGCCTGACCGTCCGCAACGACAGCGACATCGTCGAGGCGTACCGTCTGGAAGTCGTCGGCGACTGCGCTGCCTGGACCACGGTGGAGCCCGAACGCGTTTCGCTGTACCCGGGTACGTCGGAAACGGTGACGATCCGTCTGGCGCCGCCCCGCTCGCCCCAGGTGCGGGCCGGGGAGGTACCGCTCGCCGTGCGCGTGCTGCCGACCGAGCAGCCCGAGGCGGTCCGGGTCCCCGAGACCACCGTGCACGTGGAGGAGTTCCGGGAGCTGAGGGCGGAGAGCGCTCCCAGACGCCGTCGCGGCTGGCTCCGCGGGCGCTACCGCATCGCCGTCCGCAACGAGGGGAACGCCCCGGTGCGGGTGGGATTCACGCCCGCGCAGCCCGGTGAGGACCTGAAGTTCGACTTCGCCCCGGCCGCCCTGAAGCTGGAGCCGGGCGAGTCCGCCGAGGTGGTGCTGAAGGCCCGGGCCGGCGGCCCGGTGTGGTTCGGCTCCCCCGTGACCTGGCCGTTCACCGTGGAGGTGGCCGAGACCGAGGACGGTGAAGAGGCGGACGGCGCCACGGCGCGGACCGGCGCCACGGCGCGGACCGGGCCGGAGAGCGTACGGGCGCCGCTGGAGGTGGAGTTCGTCCAGATCCCGATCTTCCCGACGTGGCTGCTCGCCGTGCTGGCCGCGCTCCTCGCGCTGCTGCTCGCCTGGTTCATGCTGGTACGCCCGGCCGTGCGCAGCACCGCCAAGGAGGCCGCCGCCGAGGCGGCGAGGAATCCGGCGCCCGCCGCGGACGGGGCGGGGCAGACCCCGGTGGCCGGAAGCGGCACACAGCCGGGCGGCGCGGGCACGGCCCCCGGCGCGGCGAAGGGCGACCGGCCCACCGGAGGCGGCGCCACGGGCGGCGGCGGAACCGCCGGTGCCGGGGGCGGGCTCCAGAGCTCGGCCACCATCGACCTGCAGACGGCGGGCGGCCAGTCCAAGACGGGTACCTACACGGTGCCCGCGGGCAAGGTGTTCGGGATCACCGACCTCGTCGCGGCGAACTTCCAGGGCGACGAGGGCGTGGTGACGATCACCTTCGGCGACCGCAAGATCACGACGATCGCGCTGGAGACGTTCCGAAACCAGGACTACCACTGGGTCACCCCCATCAGCATCACCGAGAGCCAGACTGTGACCGTCCAGGTGACCTGTGCAAAGCCGGGCACGCCGGCCACCGGCCGTCAGGCGCAGGAGTGCCACGAAGTCCTCAACGTGAGCGGTGTGCTGAGCGACCTCAGGTGACCCGAGCGGCACGGACATCGTCCGTCAGGCTCGCCCAGGAACAAAGCGGACCCGCTCCGGTCCGTCCGGAAAGTGCTTACCGGGCGGACTGGTGACGGGTCGTCGGCATTGAAGCGTTCCGGTGCGGTTACGCCGTTCCACGGCTATTGCCGCCCTACTGGGCGGTAGCGGCGCCGCCGGAGAAAACATGGCCGTATTTCGATGTTCGAACACAACTGCCCGTCCACCGCTCCCGCTCCCACCGGGCGCCGGAGGCGGGCACCGCCACGTTCCGGCCGCAGCACAAGCCGCCGGGCTCGCGAAACGTCGGGGTCAGGGCCAGACCAGGCAGTACGGCTGGTGTCCCGCCTCGTGCAGGCGGTGGCTGAAATCCTGCCACTCGTGGAGCAGCTGGTAGACGTTGAAGGCGTCGCTCGGGCCGCCGCGGTCCGGGACCGTGGACCAGATGAAGGCCGCCGCGCCCACGGACTCCTCGCCGATGCCGCGCAGCGGGTCGACCACCGTCATGGGGAGCTTGACCACCGCGTAGTCGGGGTGGAGGACGACGAGCTCCAGCGGGGGCACCTTGTGCAGGGGTATGCCCTCGATGCCGGTCAGGACCATCGCGGCCACCGTCTCCGGCTTGATCTTGGTGAAGAGGCCGCCCATGCCGAGCTCGTCGCCGCCGAGCTCCTCCGGCCGCATCGTCACCGGGACCCGCGCGGCCGTCGCGCCGTCCGGGGCGCCGAAGTACTTGTACGTCACTCCCATGCCGCGGCCCCTGGGCATGTCCTGCGGATCAGGTGCGGGCTCCGGTACGGCGTCGGCCGCCTCGGTGGCGCGCCGGCGGTGCCTGCCCCGGCGGCGGGCCTCGCGGGCCTCACGGGCTTCGCGGGCGCGCTGCGGATCGAGGCCGTCCGTACCCTCGCCCGGTCCACCACCGCGTTGCATATCTCCACCCGACTGGTCTTGCTCGCCACGGCCCCGCGGCCCCCGCCACGCAGCCTGATCATCATGGCAGTGACCTCCCCCGCGGCGACGCGGTGAAACGCCCGCCCGCAAGTCTGTCGCAGCCTCTGAGACCATGGCTGGTGTGAGCTACCCGTACCCGTATGAAGCCCCAGTTTCGCAGACGCTCTTCGAGCGCGCCTCCCTCGTGACCCCCGGCGGCGTGAACTCTCCCGTGCGCGCCTTCCGCGCCGTGGGCGGTACGCCCCGGTTCATGGTGTCCGGCACCGGTCCGTACCTGACCGATGCCGACGGACGCGAGTACGTGGACCTCGTCTGCTCGTGGGGGCCGATGATCCTCGGCCACTCCCACCCCGAGGTGATCGAGGCAGTCCAGGCCGCCGTCGCCCGCGGTACCTCCTTCGGCACGCCCGGTGAGGGCGAGGTGGCGCTCGCGGAGGAGATCGTCGCGCGCGTCGCCCCCGTGGAGCAGGTGCGGCTCGTCTCCTCCGGGACGGAGGCGACCATGTCGGCGATCCGGCTGGCACGCGGCTTCACCGGTCGCGCCAAGGTCGTGAAGTTCGCCGGCTGCTACCACGGTCACGTGGACGCGCTGCTCGCCGCCGCCGGTTCCGGTTTGGCGACTTTCGCTCTGCCCGACACCCCCGGCGTCACAGGTGCGCAGGCCGGCGACACCATCGTGCTCCCCTACAACGACCTCGAAGCGGTACGGGCGGCCTTCGCCGCGCACCCCGGCGAGATCGCCTGCGTGATCACCGAGGCGGCGCCCGGCAACATGGGCGTGGTCACCCCCGCCGAGGGCTTCAACCAGGGACTCGCGGACCTCTGCCGCGAGAACGGCGCGCTCTACGTCTCCGACGAGGTCATGACCGGCTTCCGGACCTCCCGCGCCGGCTGGTACGGCGTCGACGGCGTCAGGCCCGACCTGATGACCTTCGGCAAGGTCATGGGCGGCGGCTTCCCCGCCGCGGCCTTCGGCGGCCGCGCCGACGTCATGGGCCACCTCGCGCCCGCCGGGCCCGTCTACCAGGCAGGCACGCTCTCCGGCAATCCCATCGCCACCGCCGCGGGCCTCGCGCAGCTGCGCCTGCTCGACGCGGCCGCGTACGAGAAGGTCGACGCCGTCTCGGCGCAGATCCAGTCCCTGGTCACCGGGGCGCTCGCGAAGGAGGGCGTGGCGCACCGCCTGCAGACCGCGTCCAACATGTTCTCCGTCTTCTTCACCGAGGACGTGGTGCGCGACTACGACGACGCGAAGAAGCAGGAGAGCTTCCGCTTCAACGCCTTCTTCCACTCGATGCTGGCGCAGGGCGTCTACCTGCCGCCGTCCGCCTTCGAGTCCTGGTTCGTCTCCACCGCCCACGACGACAAGGCGATCGAGCGCGTCGCGGCCGCACTGCCGGCCGCCGCCCGTGCCGCCGCGGAGGCCACCGCATGAGCCAGGACGGCCGCGACCCGAAGCCCGCCTCCGACCTCACCGTCGTGCACCTGGTGCGCCACGGCGAGGTGCACAACCCGGACGGGGTCCTGTACGGGCGCCGTGAGGGCTACCACCTCTCCGACCTGGGCCGCCGGATGGCGGACCGGGTCGCCGAGCACCTTCGGAGCCGGGACATCGCCTACGTGGTGTCCTCCCCGCTGGAGCGGGCGCAGGAGACGGCCGAGCCGATCGCCAAGGCCCACGGCCTGGACCTGGCGACGGACGCCCGGCTGCTGGAGGCGGAGAACGTCTTCGAGGGCAAGACCTTCGGCGTCGGGGACGGCGCGCTGCGCAAGCCCGGCAACTGGAAGCACCTGACGAACCCGTTCAAGCCCTCCTGGGGCGAGCCGTACGTCGAGCAGGTGGTCCGGATGATGAGCGCGCTGGAGGCCGCGCGCGACGCGGCCCGCGGCCGCGAGGCGGTGGCGGTCAGCCACCAGCTGCCGATCTGGATCGTGCGCAGCTTCGCGGAGAAGCGCCGGCTGTGGCACGACCCGCGCCGCCGGCAGTGCACCCTGGCGTCCCTGACGTCCTTCACGTTCCAGGGCGAAAAGCTCGTCTCCGTGGGCTACAGCGAGCCGGCCCGGGATCTGGTCCCGGCCCACCTCCTGGCCGGTGCGAAGCCGGTGAAGGGCGCGTCCAAGGCGTTCGGCGCCTGACCCGACACCCGACCCGGCCTGCCCCGGCGCGGCCTGACCAGGCGACACCTGATCCGACGGTCTGTTACGGACCGTTACAGGCCTGTCTAATTAAATACAAGATGCGCGGGAATCACCGTGTCAGCACACATGTCCGGTCCGTTCGCCCGTTTCCACGGGCTGCGGGCCGGGGCGTGTCGACGACGAGGGGGACGGTGACATGCGCGACGACAGGGGAGTCAGTCGGAGGGGGCTGCTGGGACTGGGGCTTGGCGCCGCGGCCGCGATGGGAGTCGCCGGCTGCGGCCTGCCCGACGTGTCCGGTCCCGGCGCTCCCGGGCCCGTGAAGACCCCGAAGCCCGGCGAGCGGCCGCCGGGCAAACCCATCGGTGACGGCTCCACCGCCGACACCGGCCCGCAGCCCCACCAGCCCGACCGGCCCGTGCCGCTCCAGCCCGGCGAGACGCCGCCGCAGTTCGTGGTCTTCAGCTGGGACGGTGCGGGCGAGGTCGGCAACGGCCTCTTCCCTCGCTTCCTCAAGCTCGCCAGGGACCACGGCGCGTCCATGACCTTCTTCCTCTCCGGCCTCTACCTGCTGCCCGAGTCGAAGCGGAGTCTGTACCGCCCGCCGAACAATCCCGTCGGCGCCTCCGACATCGGCTACCTCAAGGACGAGAACATCCGCGCCACCCTCGCCTGCGTTCGCGAGGCGTGGCTCGACGGGCACGAGATAGGCACGCACTTCAACGGCCACTTCTGCGCAGGCCCCGGCTCCGTCGCCCGCTGGACCCCGGCCGACTGGGAGAACGAGATCGACCAGGCCGTGTCCTTCGTCACGGGCTGGCGCACGAACACCGGCTTCACCGACCTACAGCCCCTGCCCTTCGACTACCGCAGGGAACTGACCGGCGCGCGCACCCCCTGCCTCCTCGGCCGGGACGGCCTCCTGCCCACGGCCCGGAAGCTGGGCTGGCGCTACGACTCCAGCTCGCCCGGCGGCCTCCAGGTCTGGCCCGAGCGCCGGTCGGGCGTATGGGACCTGCCGCTGCAGTCCCTCCCCTTCCCCGGGCACTCCTTCGAGGTGCTGTCGATGGACTACAACATCCTCGCCAACCAGTCGAAGAACACCACCCGGGGCGTGCCCGCCAACTACCCGGCCTGGCGCTCCCAGGCCACGGCCACCTACCTCGGCGGCTTCCGCCGGGCCTACGAGACCAACCGCGCGCCCCTCTTCATCGGCAACCACTTCGAGGAGTGGAACGGCGGCATCTACATGGACGCGGTCGAGGAAGCCCTCAAGGGCATGGCGGACAAAAAGGACGTAAGGCTCGTGTCCTTCCGGCAGTTCACCGACTGGCTGGACGTCCAGGACCCCAAGGTGCTCGCCCGGCTGCGCACCCTCGGCCCCGGCCGGTCACCCGCCGGTGGCTGGAACACGTACCTCACCGCCGCCTGACACATCGCCTGACCAGGGCGTTGACACCCGGCCGGGGGGTGCGGAAAATCCGCGAATTGCTCATGCGAAACTTTTCACATGAGCCTTAGCCGCGCCCCCCGCCGCCGCTCAACCAGCGGCCGCGCCCTCCTGCTGACCGCGGTGACCGTCACCGGCGCCCTCACCCTCACGGCGTGCGACGGTTCGGACAGCGGCAAGCCGACCGGCAGCGGCGGCAACTACGTCACGGGCGCGAGCGGCATCTCCACCGCCGCCAAGGGCGAGCGCAGCGAGGCCCCGGGGCTCGACGGCGAGACCGTCGACGGCAAGGCCCTCGACACGGCCGCCCTCAAGGGCAAGGTCGTCGTCCTCAACGTCTGGGGCTCCTGGTGCCCGCCGTGCCGGGCCGAGGCCCCCGCCTTCGCGAAGGTCTCCAAGGAGTTCACCGACGCCGGCAAGGACGTCGTCTTCGTGGGCCTCAACGTCCGCGACTACAGCAAGCAGAACGCCGCCTCCTTCGAGGAGACCTTCGGCGTCCCCTACCCGAGCCTCTACGACCCCGACGGCAAGCTGCTGCTCCGCTTCCCCAAGGGCAGCCTCTCCCCGAACGCCATCCCCTCCACGCTCGTCCTGGACCGGGAGGGCAAGATCGCCGCACGCACCCTGGCCCCCCTCGGCGAGGACCAGCTGCGCTCCATGATCGACCCCGTCCTCGCGGAGCAGTGACCTCGTGGTCGACTACGTGCTCGCCGCCGAGGCCACCGGGGTGAACGAGACGGTCCTGAACGGAGCGCTGCTGCTGGCGCTGCCGATCGCGCTCCTCGCCGGACTGGTCTCCTTCTTCTCGCCCTGCGTCCTGCCCCTGGTCCCCGGCTACCTCTCCTACGTGACCGGAGTCAGCGGCGCCGACCTCGCCGAGGCCCGGCGCGGACGCATGCTGGCGGGCGCGCTGCTGTTCATCGCCGGGTTCACCGCCGTCTTCGTCTCCACCGGCGCGCTCTTCGGCTTCTTCGGCCAGACCCTCCGGGAGAACAACGAGATCATCTCCCGCGTCCTGGGCGCCGTGGTGATCCTCATGGGCCTCTTCTTCATGGGCGCCATCCCGGGGCTGACGATGCGGGAGTTCCGCTTCCACCGGAAGCCGGCGGCGGGCCTGCTCGGCGCGCCCCTGCTCGGCGTGCTCTTCGGGGTCGGCTGGACCCCCTGCATGGGCCCCACCCTCGCCGCCGTCACCACGCTCTCCCTCGACCAGGCGAGCGCCGGCCGCGGCGCGCTGCTGACCGTGGTCTACTGCCTGGGCCTGGGCGTGCCCTTCGTCCTCGCCGCGATCGCCTTCCGCAAGGCGCTCGGTGCGTTCGGCTGGGTGAAGAAGCACTATGCGTGGGTGATGCGCATCGGCGGCGGCATGCTGATCCTCACCGGCCTGCTGCTCGTCACAGGTTTGTGGGACAGCATCGTCACCGACATGCAGGCCTGGACCCAAAGCTTCACGGTGGGGATCTGAGGAACCGACGGACATGAGTACGACTGACAAGGCGTCCAGCGAGGCGTCGCACGAGCCCGTCCCGGCGGACGCCGCAGAGGCCGCGGCCCCGGCGGACGCCGCAGAGGCCGCGGCCGGCTCCCAGCTGTCCACCGCCCCCGCCGAGGACGGCGGTCCCGTCGGCATCGGCGTGATCGGCTGGGCCCGCTGGTTCTGGCGGCAGCTCACCTCCATGCGGGTGGCGCTGATCCTGCTCTTCCTGCTGTCCCTGGGAGCCATCCCCGGCTCCCTCGTCCCGCAGACCAACGTCGACGCGATGAAGGTCGCCGAGTGGAAGCGGGAGCACTCCTCCTACGTCGGCGTCGCCGAGGCGCTCCAGCTCTTCGACGTCTACAGCTCGGTGTGGTTCTCCGCGATCTACCTGCTGCTGTTCGTCTCGCTGATCGGCTGCATCATCCCGCGCGCCTGGCAGTTCGTCGGCCAGCTCCGCGGCCGCCCGCCGGCCGCCCCCAAGCGGCTCGACCGGCTGCCCGCCCACACCACCTGGCGTACGGACAGCACCCCCGAGGAGGTCCTGTCGTACGCGCGGACGATGCTCGGCCGGAGGCGCTTCCGCACCGAGGCGGGCGGCTCCCACGTCGCGGCCGAGAAGGGCTACCTCCGCGAGGCCGGCAACCTCGTCTTCCACGTCGCGCTGATCGTGATGCTCGTCGCCTTCGCCTGGGGCCAGTACTTCAAGTCCGAGGGCGGCAAGCTGGTCCTGCGCGGCAGCGGCTTCTCGAACACGCTCACCCAGTACGACGACTTCAAGCCCGGCACGCTCTTCCACCCGGACGACCTGCCGCCGTTCAGCTTCACGCTGGACCGCTTCGACGCCACCTACGAGATGTCCGGCCCGCAGCGGGGCACCCCGCGCGACTTCAAGGCGTACGTCACCCTCAGCGAGGGCGCCCACGGAACGCCGCAGAAGCGCGAGATCCAGGTCAACGAGCCCCTCGAAATCGACGGGTCCAAGGTCTACCTCCTCGGCCACGGCTACGCGCCGATCATCTCGGTGACCGACCCCACCGGGAAGGTGATCTACAAGGACGCCGTCCCGGTCCTCCCGCAGGACGGCAACCTCACCTCCACGGGAGCCGTCAAGGTCACCGACGGCTACAAGGACAAGAACGGCAAGGCCGAGCAGCTCGGCTTCACCGCCGTCTTCGTCCCGACCTTCGCCGGCGAGGGCAAGGGGACGATGTTCTCCCAGTTCCCCGCCCTCCTGAACCCGCAGCTCATGCTCAACGCCTGGCACGGCAGCCTCGGCGTGGACTCGGGCCTGCCGCAGAACGTCTACCGCCTCGACACCTCCAAGATGGAGATGTTCAAGGACGAGTCGGGACAGCAGCTCATCAAGAGGCTGGCGCCCGGCGAGACGATGGCCCTGCCGGACGGCGCGGGCACCGTGAAGTTCGAGGGCATCGAGCGCTGGGCCACCTTCTCCGTCACCCGGCAGCCCGGCAGCGGCCTCGCCCTCGCGGGCGCGATCGCCGCCATCGCGGGCCTGGCCGGGTCGCTGTTCATCCAGCGCCGCCGGATCTGGGTGCGCGCGGTGACCGGCGAGGACGGCGTCACCGTCGTCGAGATGGCGGGCCTCGGCCGCAGCGAGTCCGCCAAACTGCCGCAGGAGCTGGCGGAGCTCGCCGCCACGCTGCACGAACAGGCGCCGACCGCGACGCCCGCCGGCCCCGCAGATTCCTCGAAACGTGTCGAAGAAACCCCCGAAGGAGAGCGCGGATGACGCCGCTCGCTGCCGCAGCCAACGAGAACCTGGCTCAGATCAGCAACTACCTGATCTATTCGTCGATGGCGGTCTACACGCTCGCCTTCTTCGCGCACATCGCCGAGTGGACCTTCGGCAGCCGCAGCAAGGTGGCCCGTACGGCCGCCGCGCTGACCGGCCCCACGGAGGCCGTGGCCCCGGCCGTGCAGGTCCGGGGCAAGGGCGGCGCCACCGCCGTCCTGGACCGGCCGAAGGTCACCACCCGCTCCGGCGCCGGGACCCGTGACGTCCCCGACGGCCCCGGCGCCGCCGGCGGCACCGCGCAGGGCGACCTGTACGGCCGGATCGCGGTCTCGCTGACCGCGCTCGCCTTCCTCGTCGAGGCGGCCGGCGTCGTCACCCGCGCCATGTCGGTCGAGCGGGCCCCCTGGGGCAACATGTACGAGTTCTCGATCACCTTCTCCACGGTGGCCGTCGGCACCTACCTGGTGCTCCTCGCCCTGAGGAAGAACGTCCGCTGGCTCGGCCTGATCCTGGTCACCACCGTCCTGCTCGACCTCGGCATCGCCGTCACCTGGCTCTACACCGACAGCGACCAGCTGGTCCCGGCCCTGCACTCGTACTGGCTGTGGATCCACGTCTCCACCGCCATCTTCTGCGGCGCCGTCTTCTACCTCGGCGCGGCCGGCACGGTCCTCTACCTCTTCCGCGACGCCTACGAGGGCAAGCTCGCCGGAGGCGGCACGCCGGGCAGGATCGCCTCCTCCGTCCTGGAGCGGCTGCCGTCCGCGGCCTCGCTGGACAAGTTCTCGTACCGCATCAACGCGGCCGTCTTCCCCCTGTGGACCTTCACGATCATCGCGGGCGCCATCTGGGCCGGCGACGCCTGGGGCCGCTACTGGGGCTGGGACCCCAAGGAGGTCTGGTCCTTCGTGACGTGGGTGGCGTACGCCGCCTACCTGCACGCCCGCGCCACCGCCGGCTGGAAGGGCCGCAAGGCCGCCTACCTGGCGCTCTTCGCCTTCGCCTGCTGGATCTGGAACTACTACGGCGTGAACATCCTGCTCAGCGGCAAGCACTCGTACGCGGGCGTCTGACCGGCGGGAGTGGGACGCTGGTGGCATGTCCCTCGTGAGCCATGCCACCAGCGAACGGCGCGGCGAGAACCACTGGCTGCTCCGCTTCGAGCTCCACCTGCCCTACTCCTACGAGGCCCTCTGGCACGCCGTGACCACACCCGACGGGCTGCGCGGCTGGCTGGCCGCGGCCGACGTCCTGGAGCGGCACCTCGGCGGGGCCGTCACCCTGCGCTGGCCGAACACCGGGACCGTGGCGAGCGGGCACGTCTCGGCCTGGGACGTGGAGCGCGTCGCCGAGTACACGGTGAGCGGGCACGGCCGGATCCGCTTCCACCTGGAGGCCGTGGGCACCGACTCCACGGTCATCCGCTTCCTGAACGAACGCGGCGGGTCCGACGAGGACCGCCTGGACTGCCTGGCCGGCTGGCACGAGCACTTCGAGCTGCTGGAGGCCGCGCTGGCGGGGCAGCCGGCGGACTGGTCCGCCTGGACGGGCCGCCGCTGGGCCGACCTGCGCGCTTCGTACGCCTCCTTCAGCGAGGTCCGCAGGGCGTCCTGAGACCCCGCCCCGGCGCGGATCGCGGTCGCCCTCCCGGGGTGCCGCGCGCTCACCACACCGGGCGCAGGGGCGGCAGCCCGTCCACCCCGTGAAGCGCCCGCACGACATGGCCCAGCTCCCGGCGCAGGGCGGCGAGGTCGGCGGTGCCCGCGAGCTCGTCCTCCAACCGGTGCAGGACCCGCCCGGCGACGGAGAGGTGTTCCCGGGCCGCTCCCGTGAGGACCACCAGCTTGCGGCGTCCCCCCTCCGGGTGAGGCTCGCGCCGGACGTATCCGCGCGCCTCCAGGTCGTCGACGATCTGCCCGGCGGCCTGCTTGGTCACCCCGAGCCGTTCGGCGAGCTCGGTGGCGGTGGCGCCGCCGCCCTTCAGGGCCTGGAAGGCCATGCCGTGCACGGGCCGCAGGTCGCCCTGCCCCACCTCGGCCAGCCGCCGGGTGAACTCGCCCAGCACCAGCTGGAAGCCCAGGCCGAGCAGGAACGTCAGCTCGACGTCGGCGTAGTCGTCTCTCGTCACGCGAAACATGGTGACACGGCGGGGTCAAGCTGCTTTACTCGGTGCGAGTAAAGCAACTTGACTCACTGGTCGGAAGAACCGGAAGAACCGGAAGAAACGAGGCCCGCCTTGCACGTGATCGCCACCACCGCCGACGACGTCACCACCACCCCGAACGCCACCATGACCGCGCTCGCCACCCCCAGCCGCGGCAGCTCCGAGCTCAGCACCTGGCACGTCGACATGCCCGCCGGAGCCACCGGCCCCGAGCACTCCGTCAGCCGCGAGCAGGTCTGGACCCTGACCGCCGGCTCCCTGGAGGTCACCTGCGGCGACCGCACCGAGAAGGTCACCGCAGGCCGGACCCTGGTCCTGCCCGCGGACGCACCGCGCAGGATCCACGCCCCCGAGGCCTTCCAGGCCTACGTCGCGATGCGCGCGGACGGCGTGGTGACGGTGACGGGCGAGGACGGCACCCGCGTCCTGCCCTGGGCGCGGTGAGGACCGCCGCCCGTCGACCGGTCCGGCCGGCCCGAACAGGGGTCAGTCGGAGTCCTTGTCCTTGTCCCGGTCCTTGTCCCGGCCCTTGTCCCGGTCCTCCCGGTCCTTGTTCTCCTGCTCCTCGCGCAGGGACTTCAGGAACTCCGGGTTGTCGTCGGGGGCCACCCACTGGCCGCGCCCCCGCGGGCCGCGCCCGCCGCCGGAGGCCACCCGCTTCTTGCCCGCGAACAGCCACACCACCGGCCCCACGACGGAGAAGAGCAGGATGATGAGCACCCACATCGCCTTGGGCAGGTGCTTGACCTCCTCCTCCGGCGTGTTCAGGCAGTCGATGAAGGCGTAGATGGTCAGCGCGATGATCAGCAGGAACGGCAGATAGCGCAGCACGGTGTGGGACCGACTCCCGGGCAGTGACGGCGGGCCCGCAGGGGGCCCCGGTGACGCTCCCAGCGTAGTTGGTGACGGATACTGACCCCTATGGCTTACGACGATCTCCGCTCGCTGCTCCGGGCTCTGGAGCGAGAGGGCGACCTCAAGCGCATCAAGGCCGAAGTCGACCCGTACCTGGAGGTCGGGGAGATCGTCGACAGAGTGAACAAGGCGGGCGGTCCCGCGCTCCTCTTCGAGAACGTCAAGGGCTCGGCGATGCCGCTGGCCATGAACGTCTTCGGTACCGACCGCCGCCTCCTGAAGGCCCTCGGCCTGAAGTCCTACGCCGAGATCAGCGAGAAGATCGGCGGCCTGCTCAAGCCGGAGCTGCCGCAGGGCTTCATCGGGGTCCGCGAGGCCTTCGGCAAGCTCGGCTCGATGGTCCACGTCCCGCCGAAGAAGGTGAAGGGCGGCTCCGCGCCCGTCCAGGAGGTCGTCCTCACCGGCGACGACGTCGACCTGGACCTGCTGCCGGCCCTCTTCACCTGGCCCAAGGACGGCGGCTCCTTCTTCAACCTCGGCCTGACCCACACCAAGCACCCCGAGACGGGCGTGCGCAACCTCGGCCTCTACCGGCTGCAGCGTCACGACAAGCGCACCATCGGCATGCACTGGCAGATCCACAAAGACAGCCGCAACCACTACGCCGTCGCCGCCGCCAAGGGCGAGCGGCTGCCGGTCGCGATCGCCTTCGGCTGCCCGCCCGCCGTCACGTACGCGTCCACCGCGCCGCTGCCGGGCGACATCGACGAATACCTCTTCGCCGGCTTCGTCGCGGGCAAGCGGATCGAGATGGTCGACTGCAAGACCGTCCCGCTCCAGGTCCCGGCCAACGCGGAGGTCGTCGTCGAGGGCTGGCTGGAGCCCGGCGAGATGCTGCCGGAGGGCCCCTTCGGCGACCACACCGGCTTCTACACCCCGCAGGAGCCCTTCCCGGCCCTGAAGATCGACTGCATCACGATGCGCAAGCGGCCGCTGCTCCAGTCGATCGTGGTGGGCCGCCCGCCGACCGAGGACGGCCCCCTGGGCCGGGCCACGGAGCGCTTCTTCCTGCCCCTGCTGAAGATCATCGTCCCGGACATCGTGGACTACCACCTGCCCGAGTCCGGCGGCTTCCACAACTGCGCGATCGTCTCGATCGACAAGAAGTACCCCAAGCACGCGCAGAAGGTCATGCACGCCATCTGGGGCGCCCACATGATGTCGCTGACCAAGCTGATCATCGTGGTGGACAAGGACTGCGACGTCCACGACCTGCACGAGGTGTCCTGGCGGGCGCTGGGCAACACGGACTACTCCCGCGACCTCACCGTCGTCGAGGGGCCGGTGGACCACCTCGACCACGCCTCCTACCAGCAGTTCTGGGGCGGCAAGGCGGGCATCGACGCGACGAAGAAGCTGCCCGAGGAGGGCTACACCCGCGACGGCGGCTGGCCCGACATGGTCGAGTCCGACCCGGCCACCGCCGCCCTCGTGGACCGCCGCTGGAAGGAGTACGGCCTGTGAGCCCGATCGCCGTCGAGGGCCCGGAACTCAACCTCGGCACCGCGCAGGCGTACGTGGTCCTGGCGCGGCCGAAGATCGACCCGACCCAGCCCGGCGTGATCGCGGCGGCCCGGGAGGCCGGCGTGAGCCCGGAGGAGTTCGCCGGCCCCGGCGACGTCTGGGCGCTGATGTACGACGCGGACGGCGACGGGGACGGCTTCGAGCTGCCCGGCGCCCGGGACACGGAGGCGGACGCCTTCGCGGAGCAGGTGCAGCAGGCCCTGGCCGCGGCCGAGCCCTTCACCGTGGAGGCCGGCAACTTCCTGCGCCTGGACGCCCGGCCCGCCGGCGCGGACTGGACGGTCACCGCGCACATCACCCCGCCCGAGGGCGACGAGGACGGCCCCGCGGCCCGGACGCTGGAGCTCGGCGCGCTGCCGGCGGCGGAACTGCTGGCCGAACTCGAACGGTTCCGGGGGGAACTCGCATGATGACCACCGCCGACGGAGTGGTCGGACAGGGGCCCGCGCCGGAGGCCGCCGGCAAGGTCAGGGCCTTCCTGCGGCTGGTGATGATCGAGCACTCGGTCTTCGCGCTGCCCTTCGCCTACATCGCGGCGCTGACCGCCATGTTCCAGCTCGACCGGACCGTGCACTGGGGCAGGCTGCTGCTCGTCACCGTGTGCATGGTGGGGCTGCGTACCTTCGCCATGGCCGCGAACCGGATCATCGACCGCGAGATCGACGCCCGCAACCCGCGGACGGCCGGCCGCGAGCTGGTCACCGGCGCGGTCTCGGTCCGTTCGGCCTGGACCGGCGCGGGGATCGCGCTGGTGGTCTTCCTGGGCTCGGCGGCCCTGCTCAATCCCCTGTGCCTGGCGCTCGCGCCGGTCGCCGTGATCCCGATGGTGGTCTACCCGTACGGCAAGCGGTTCACGGACTTCCCGCACGCCATCCTGGGCCTGGCCCAGGCGATGGGCCCGGTCGGGGCCTGGCTGGCGATCACCGGCGAGTGGTCCTGGGACGCGGTGATCCTGGGCCTCGCGGTCGGCGTGTGGATCGGCGGCTTCGACCTGATCTTCGCCTGCCAGGACGTGGCCGCCGACCGCGCGGAGGGCGTCAGGTCCGTCCCGGCCCGCTTCGGCGTCCCGGCCGCCCTCTGGGGGGCGCGCGGCTCGCACGTCGTGACCACGGCCCTGCTGGCCTGGTACGCGCTCGCCACGGACGCGGGCCCCCTCTTCTGGGCCGGCCTCGCGGTCGTCGTCGCCGCGTTCGTCTACGAGCACACCATCGTGACGCCGCACGACCTGTCCCGCCTGAACCGTGCCTTCTTCACGGTCAACGGCTTCATCGGGATCGCCCTGTTCGTGTGCGCCCTGGCCGATCTGGTGGTCCGCGGCCTGACGGTGTAGTAGCTCCATCGGGTGGGTCGATCGGCATCTGGTCGTTCGGGGTCTGACCTTCTCGCTACCGTGCGCCCTAACATCGAGTGCATGGACAGGGAGGCCGACGTGACCATCTCGGATAGCGACCGCCTGCACTCACAGCTCAGCCGGTACGAGGACATGTTCCCGGGGTACCGGACCGAGATTGTCGAGGGTGCCATCGTGATGAGCCCGGTCAAGCCCCACCACAACGAGACGATCTGGGACGTGCGGGACTTGTTGAAACCGCAACTCCCGACCGGGTGGGCCTTCATCTCCGATGTCGCGGTCCCCTTCGACGAAAGCAACGAGTTCTGCCCGGACCTCGCCGTCATTCCGGATGCCGAGCGCCGTAAGAACCTCAGCGCCTACCCGCCCGACCTCATCGAGCTGGCCGTCGAGGTCGTCTCCCCGAGCAGCGTCCGCAACGACTACGAGGTGAAGGACCGGGCCTACGCCCGGCGCGGCATCCCGCACTACCTGATCTTCGATCCGTACAAGGCGCACTGCGTGACCCTGTGGAACCCCGGCCCCGACGGCTACCGCGGCCGGGACACCATCCCGTACGGCGGGAGAGTCGCGGTCGAGACGGGGATCGGCAAGCTGCTGATCGACACCGCGGGCCTGCCCGTGGATCCCGGCGCCGTCAGCCCGTGAGGGCGGCCGGCTGCCGTCAGGCCGTGACGGCCGGGCGTCGGGCCGGGCGGCGGAAGTACAGGGCCGTCACGACGCCCGCCACCAGTCCGCACAGGTGGCCCTGCCAGCTGACGCCCGAGTCCGTCGGGAGGACGCCGGAGACGATCGTGGTGCCCCAGACGGCCGCGACACCGACGGCCACGGCGATGCCCAGCGCCCGGCGCTCCACGAAGCCCCGTACGAGCAGGTAGCCGAAGAGGCCGAAGACGATGCCGGAGGCACCCAGCGTCATGGTCCCGGACGGGGATATGAGCCAGGTGCCGAGGCCGTCGGCCAGCATGATCAGACCGCACACCGCGAGGAACCGGCGGATCCCGGACAGGGCGGCTATGAAGCCGAGGACCAGCAGGGGCACGCTGTTGGACGCGACGTGGTCGAAGCCGAAGTGGAGGAAGCCCGCGGAGACGACGCCGGTGAGGCTGCCGGGGTCGCGGGCGACGATGCCGTACTGGTCGAGGGCGTGGCCGGTGGCGTGGTCGACGACTTCCAGGATCCACAGCAGCGCGACCCAGCCCAGCATCAGCTGGGCGGCGGCCTTCGCCCGCCCGGCCCGCGTCCAGCCGGTATCCACCGTCGTGTTCAT

Protein sequences of DBSCAN-SWA_3

>NZ_CP018870|4198340:4255558|4234882_4238029_-|WP_075970817.1|DBSCAN-SWA
MLLLAPLLAVTAAAGPDDAGARPLASGAADAGESRVAYAGTRHRSLGRVVSGKSDTSTPLFGDGPVHLDVQPAALGDRLVFASRRDERAPQVYLRSADGSVRRLTRGMDAANPRLTPDGRAVVFDSAQRAATGGVQRDLWLVRTDGTGLTRLTDTPANEEHPTVSPEGGRLAYSSDGDRAAGRQVYVRPLRGGAATRLTDPANGRATEPVWNPVDDAANRDVIAYTATGGSGPRLRWTNGRADGELLAGAQAGWRTRGAAWLPDGNGLLFLSPDRTCDGKGDWDHVFQVAAHSADTPKLVYSENREIGSPTWLGPLDGGGAVVERISAAGPHAVTLQDARTDGSDPRDLGLTILDEDPEADTNTDPARDPLFRPGPGHDPWTERQSYTPDGRRIVVTRFEGDPGARIQRIWTADADGSNASVLPLAGRGPRDWDTDPAFSPDGRYLAFTRTSPGGVGEAAGPARILIADAATGAIRSEVTPPEGHPRGGDAQPTWSSDGTTLAFTRNLVINGHGGNKHVWTVPVDHLDRQRDLSATMCPGACDVIDDSPAFSPDGATIAFNRKSGGGRVDERGGILLAAATGGTCRVLLPDAARDKPGACGRELPETTGNGPYQPRDAAWTADGKSLVLTGRGDRAVNSPEKLKLVNVATGAHNLLVTGLPGRQKEPAVQQSVDLAVRAPEKAPPLTVGGSATVRVDVVNHGPAASPGTRLTVAPPLGVSVTALTAPGAACDAAALTCTLGVVRPGATVPVTATLTGVVPGEQPVEWSVTGTVLDPRPSDNAGRTVVPVREVPVPPKPTPTPMPTPAPTPPPGPAPTPTPTTPTAPPAQPPVPEAGPGVSITAQPNPGYVGGRVVATYTVANGRSALATGLRLRIGLPGGVPHDGPPPGCDRNWTCALPDLAPGARTVLRVVLSPDKALTAEITATLTTTGTDADPGDNTARQQLRILQPRIVAVPPIGRPGFVTSVRGEDFPPGTPVRFAWKPGITAAAAPTVPQADGTFIGQLLILAKDQTGPRVITASGPGFSPVQTDFLVVNGTVQPPDEVARR
>NZ_CP018870|4198340:4255558|4214079_4215579_+|WP_075970811.1|DBSCAN-SWA
MSLEHPEGAQEAEPSGGRARHRSRRGLVIAAAVVVLFGSSGSVWWIASQARTPEQRASNAAAPPPSRITGKVSDEQLVEKMDLTGKVETASRTTVTGTMPQGTSRAVVTGLPATAGKSLKAGAVVAEVSGRPVLLLPGRFPAYRDLRAGDKGPDVRQLQRALKPLYGTAVSGTYDRATVEAVRRLYAAAGYEGPSGQGQGGGASGGGASAGSATGRPAGGAAPRGGAETDGGTGAAPAANGAPSAAPDSGSDAPPAAGPAKPGETLPAAEVAYVGTLPATVVQVTAAVGDAADKPLVVLGSGGRQVRAPLTADQRTRLRDLPNDAVIRFGTGPYAGREGSLGSLTGVPDAKGGGDQQGNAKTGGQDGGDTSGTAGTTGTGTAGSGGGAGGGTRHEALFVPSGAEAEEGAVQQISVELRRSPKGALTVPVSAVWTDLGGSSTVTVTENGKERNVPVEVLFTHDGLTAVNAIDSNLGAGQSVVLVRRGKAADSSDGGGGDD
>NZ_CP018870|4198340:4255558|4204512_4205376_-|WP_107484917.1|DBSCAN-SWA
MLTALAAGAAGLTGCTGGGDGAGTSDSKAGGGTAAPAQPGKYRSLPAPCRAAADSKKLKAMLPEPDGLTPEQLDQLYAGVADSSYDGDRHVGCRWTAQTPEETRLLSVGFERVVSYDRATTSDDDKAKQVYVRLLTDAHLPFPGPATTPGPGAANPANPANPPASSPPPANAAPPANAAPPASGAPSAGAPAAGTPAPGASPSSQPELGSRVLEGLGTEAFLDDKLSPAGATAAQSRTVRIVFRTSNVIVKVEYSVQPALPGTVPPSAEIQDKARQLALALVDRFNE
>NZ_CP018870|4198340:4255558|4246579_4248328_+|WP_045321405.1|DBSCAN-SWA
MSTTDKASSEASHEPVPADAAEAAAPADAAEAAAGSQLSTAPAEDGGPVGIGVIGWARWFWRQLTSMRVALILLFLLSLGAIPGSLVPQTNVDAMKVAEWKREHSSYVGVAEALQLFDVYSSVWFSAIYLLLFVSLIGCIIPRAWQFVGQLRGRPPAAPKRLDRLPAHTTWRTDSTPEEVLSYARTMLGRRRFRTEAGGSHVAAEKGYLREAGNLVFHVALIVMLVAFAWGQYFKSEGGKLVLRGSGFSNTLTQYDDFKPGTLFHPDDLPPFSFTLDRFDATYEMSGPQRGTPRDFKAYVTLSEGAHGTPQKREIQVNEPLEIDGSKVYLLGHGYAPIISVTDPTGKVIYKDAVPVLPQDGNLTSTGAVKVTDGYKDKNGKAEQLGFTAVFVPTFAGEGKGTMFSQFPALLNPQLMLNAWHGSLGVDSGLPQNVYRLDTSKMEMFKDESGQQLIKRLAPGETMALPDGAGTVKFEGIERWATFSVTRQPGSGLALAGAIAAIAGLAGSLFIQRRRIWVRAVTGEDGVTVVEMAGLGRSESAKLPQELAELAATLHEQAPTATPAGPADSSKRVEETPEGERG
>NZ_CP018870|4198340:4255558|4254348_4254936_+|WP_078848869.1|DBSCAN-SWA
MDREADVTISDSDRLHSQLSRYEDMFPGYRTEIVEGAIVMSPVKPHHNETIWDVRDLLKPQLPTGWAFISDVAVPFDESNEFCPDLAVIPDAERRKNLSAYPPDLIELAVEVVSPSSVRNDYEVKDRAYARRGIPHYLIFDPYKAHCVTLWNPGPDGYRGRDTIPYGGRVAVETGIGKLLIDTAGLPVDPGAVSP
>NZ_CP018870|4198340:4255558|4220172_4222146_-|WP_075970814.1|plate|DBSCAN-SWA
MALPSPNLDDRRFQQLVDEAKRYVQQRAPEWTDHNVSDPGVTLIETFAYLVDQLLYRLNRVPDKNYLAFLDLLGIQLYPPSAATADVDFWLSAPQPDTVTLPAGTEVATEVTTSAGDTGEAVVFATTDDLRILPSELTRLVTAPRAGEPADRTGALTEGRDIPCFQATPEPGDALLFGLPTAVPRCVVAVRLDSRVEGVGVDPRQPPLVWEAWDGGRWQRCATDSDSTGGLNRPGEIIVYVPAGHTASVIGGTRAGWLRCRVTEPEPGQPFYSESPTVREASVFTVGGTMTVEHAERVADVPLGASEGVAGQSFRLGRPPVLLDGEPPVVEVSSPAGWQRWDVVEHFGRSAPDDRHVRVDATTGEFSFPPVLREADGTLRACGAVPPKGSRIRVTRYRTGGGPAGNVSRGAISVLRSSVPYVARVANREAARGGVAGETVDNAKLRAPEALRMQERAVTAEDYEILARRAAPSVRRVRCLPATDGGRGAGSVRVLVVPDAVADEGDRLRFEQLIPSDQVLTAITDTLGERRLIGTNLVVEPPVYQGITVVARLAAPAADADRVRDAALAALYRHLNPLHGGPDGTGWPFGRPVQYGEVFGVLQRAIGDVLVEDIRMFAADPITGRRGAPVDRVDIGTGTLVFSYQHQVVVTEPEAGA
>NZ_CP018870|4198340:4255558|4210140_4211037_+|WP_075970808.1|DBSCAN-SWA
MLAAVVTGFGGPEQVGLEQVPVPRPAAGQVRIRVAAAGLNPVDGAVRAGVFGGAGQRLGLGWDVAGEVDETGPGVTGWSRGDRVVGLHYGPVKPLGTHAEYVVLDAGAVAAAPAAVDVPTAAALPLAGLTAARAVDQLGLAPGSSVLVTGAAGVVGGLAVQLAARVGLVVTALAGAGDEELVRSLGAAAFVPRGGAPDGPVDGVLDAAVLGGDALAHVRDGGVYVGLIPNHAPAAERGIRIEEQEVAADGELLARLVSLVDEGALTLRVAEVFPLAEAAKAHERLAVPGVRGRIVLTP
>NZ_CP018870|4198340:4255558|4249432_4249948_+|WP_030026264.1|DBSCAN-SWA
MSLVSHATSERRGENHWLLRFELHLPYSYEALWHAVTTPDGLRGWLAAADVLERHLGGAVTLRWPNTGTVASGHVSAWDVERVAEYTVSGHGRIRFHLEAVGTDSTVIRFLNERGGSDEDRLDCLAGWHEHFELLEAALAGQPADWSAWTGRRWADLRASYASFSEVRRAS
>NZ_CP018870|4198340:4255558|4239250_4240561_+|WP_075970818.1|DBSCAN-SWA
MSVMPGGTATTSLTVRNDSDIVEAYRLEVVGDCAAWTTVEPERVSLYPGTSETVTIRLAPPRSPQVRAGEVPLAVRVLPTEQPEAVRVPETTVHVEEFRELRAESAPRRRRGWLRGRYRIAVRNEGNAPVRVGFTPAQPGEDLKFDFAPAALKLEPGESAEVVLKARAGGPVWFGSPVTWPFTVEVAETEDGEEADGATARTGATARTGPESVRAPLEVEFVQIPIFPTWLLAVLAALLALLLAWFMLVRPAVRSTAKEAAAEAARNPAPAADGAGQTPVAGSGTQPGGAGTAPGAAKGDRPTGGGATGGGGTAGAGGGLQSSATIDLQTAGGQSKTGTYTVPAGKVFGITDLVAANFQGDEGVVTITFGDRKITTIALETFRNQDYHWVTPISITESQTVTVQVTCAKPGTPATGRQAQECHEVLNVSGVLSDLR
>NZ_CP018870|4198340:4255558|4205608_4206802_+|WP_075970807.1|DBSCAN-SWA
MSYVEVPGAQVPIRMWTDPASVEAGAMQQLHNVATLPWIKGLAVMPDVHYGKGATVGSVIAMKDAVCPAAVGVDIGCGMSAVKTSLTANDLPGDLSKLRSKIEQAIPVGNGMHREAVDPARLYGFTEAGFGDLWERFDYVADAVKFRRDRAMRQMGSLGQGNHFCEVCIDTSGSVWLMLHSGSRNIGNELAAFHIGVARGLSHNQNLVDRDLAVFLAATPEMEAYRNDLFWAQEYAKYNRAVMMSLFKEVFRKEFRKAKVSFDREISCHHNYVAEERYDGMDLLVTRKGAIRAGSGDYGIIPGSMGTGSYIVKGLGNEKSFNSASHGAGRKMSRTAAKKKFSARDLAEQTKGVECRKDSGVVDEIPGAYKSIEQVIDQQTDLVQVVAKLKQVICVKG
>NZ_CP018870|4198340:4255558|4208206_4208719_+|WP_030029773.1|DBSCAN-SWA
MVAVRRVAVRSVVVAGLLACGAGVPGPAQASAGAPAQVSAWAGPEADVSYHGRVALSGARLRVWLVPENDGPAALPNATLRVRLSADLADRQQLAQGCARAGLREVVCETGPLPSHGRGRHVGLALELRERVPEVAVRVDTWWNGGATDRNHANDDHVVLALDTGDAYAF
>NZ_CP018870|4198340:4255558|4202179_4203499_-|WP_045321424.1|DBSCAN-SWA
MAAMQLTRTHRILIGVVVAGAVVIAGIGFAGSYAAVRELAEKKGFGSFSLVFPIGIDAGICVLLALDLLLTWMRIPFPLLRQTAWLLTAATIAFNGAASWPDPLGVGMHAVIPILFVVTVEAARHAVGRIADITADRHMEGVRITRWLLSPLPTFKLWRRMKLWELRSYEQAIGMEQDRLIYQARLQARYGRFWRQKAPVEALMPLKLARIGVPLSQTAPDALAATGIDPAVLPPLEQQLAGSAPALEVSAAGAADPLQAQAQQPVQAPQSAVQQGAPGAVAAHVPPAFAVDPTAMPAAHNSAWFAAPKAPQAAYEGGYNPQYVEGLEPTPVLPPMGPEEPQAQQLPIPEPRHEAAADGQFPEQVPVVDSPDEVEFAQIAYKVFCALAEETQDYPTAEALDIMLADRYGVTHPRSGSLLRRMISSFRQQHHKDREAEPA
>NZ_CP018870|4198340:4255558|4206936_4207701_-|WP_030029775.1|DBSCAN-SWA
MSTAATRTAVVTGASSGIGAATARQLAAAGYHVVLTARRKDRIEALAAELTQAGHAATAHALDVTDRAAVDALAASLDRCDVLVNNAGGALGAEPVATGDPADWRTMYEVNVIGTLNVTQALLPALTASGDGTVVVLSSTAGHATYEGGAGYVAAKNGARVLAETLRLEIVGRPVRVIEIAPGMVKTDEFAKTRFRGDAEKAEKVYEGVAEPLTADDVADTVTWAVTRPSHVNIDLLVVRPRAQASNTKVHREL
>NZ_CP018870|4198340:4255558|4248324_4249407_+|WP_045321404.1|DBSCAN-SWA
MTPLAAAANENLAQISNYLIYSSMAVYTLAFFAHIAEWTFGSRSKVARTAAALTGPTEAVAPAVQVRGKGGATAVLDRPKVTTRSGAGTRDVPDGPGAAGGTAQGDLYGRIAVSLTALAFLVEAAGVVTRAMSVERAPWGNMYEFSITFSTVAVGTYLVLLALRKNVRWLGLILVTTVLLDLGIAVTWLYTDSDQLVPALHSYWLWIHVSTAIFCGAVFYLGAAGTVLYLFRDAYEGKLAGGGTPGRIASSVLERLPSAASLDKFSYRINAAVFPLWTFTIIAGAIWAGDAWGRYWGWDPKEVWSFVTWVAYAAYLHARATAGWKGRKAAYLALFAFACWIWNYYGVNILLSGKHSYAGV
>NZ_CP018870|4198340:4255558|4211148_4212159_-|WP_075970809.1|DBSCAN-SWA
MRAIQVYEVGGPEVLQEAEVDQPRPGPGEAIVEVAASGVNFLDVYHREGRYSLPLPFTPGTEGAGTVVEVGPDVTDVAVGDRVGWVEIPGSYAERAVVDASRLVPLPDDIGFETAAAVLLQGMTAHYLVKDAYPVQGGDTVLVHAAAGGMGLLLTQLITHLGGRVIGTTSTTAKAELAKRAGAAEVIVPSAVDDLAAEVRRLNGGQGLPVVFDGVGAHTFDASLAGLRTRGHLVLFGAASGAVPPFDPMRLAHGGSLTLIRPSLGDFIADRSELLRRAADVFEWVRSKALEVTVTGRYALSEAARAHSDLEARRTTGKLLLLPDAAAAGRRDGTHT
>NZ_CP018870|4198340:4255558|4245161_4245788_+|WP_075970821.1|DBSCAN-SWA
MSLSRAPRRRSTSGRALLLTAVTVTGALTLTACDGSDSGKPTGSGGNYVTGASGISTAAKGERSEAPGLDGETVDGKALDTAALKGKVVVLNVWGSWCPPCRAEAPAFAKVSKEFTDAGKDVVFVGLNVRDYSKQNAASFEETFGVPYPSLYDPDGKLLLRFPKGSLSPNAIPSTLVLDREGKIAARTLAPLGEDQLRSMIDPVLAEQ
>NZ_CP018870|4198340:4255558|4215571_4216246_+|WP_075970812.1|DBSCAN-SWA
MTDPAPVIEMAGIAKTYPGPPPVRALTDVTLTIRPGRLAAIVGPSGSGKSTLLSVLGLLDVPTRGRYLLGGRDTTDLSERARTALRASTLGFVFQAFHLVPHLTCVQNVALPLVHLGVPRAARRPQAVAALESVGLGHRLDVRPTTLSGGERQRVAVARAIVHRPAVVLCDEPTGNLDTANSARVMDLLTGLVAQDRAVVVVTHEPDVAARADHVFKVVDGRVS
>NZ_CP018870|4198340:4255558|4254952_4255558_-|WP_030026278.1|protease|DBSCAN-SWA
MNTTVDTGWTRAGRAKAAAQLMLGWVALLWILEVVDHATGHALDQYGIVARDPGSLTGVVSAGFLHFGFDHVASNSVPLLVLGFIAALSGIRRFLAVCGLIMLADGLGTWLISPSGTMTLGASGIVFGLFGYLLVRGFVERRALGIAVAVGVAAVWGTTIVSGVLPTDSGVSWQGHLCGLVAGVVTALYFRRPARRPAVTA
>NZ_CP018870|4198340:4255558|4207763_4208099_-|WP_030029774.1|DBSCAN-SWA
MLIARSIALFTLAALLEIGGAWLVWQGVREHRGWAWIGAGVIALGLYGFAATLQPQGDFARVLAAYGGVFVAGSLAWGAVADGYRPDRWDIVGALVCLAGMAVIMYAPRGR
>NZ_CP018870|4198340:4255558|4240873_4241311_-|WP_030008917.1|DBSCAN-SWA
MGVTYKYFGAPDGATAARVPVTMRPEELGGDELGMGGLFTKIKPETVAAMVLTGIEGIPLHKVPPLELVVLHPDYAVVKLPMTVVDPLRGIGEESVGAAAFIWSTVPDRGGPSDAFNVYQLLHEWQDFSHRLHEAGHQPYCLVWP
>NZ_CP018870|4198340:4255558|4198340_4200110_-|WP_030028041.1|tRNA|DBSCAN-SWA
MASVPSLASSVNQRVADALASALPEAGGADPLLRRSDRADFQANGILALAKKAKANPRELATTVVEGIPAGDLIKEIEVSGPGFLNITVADSAIVSTLAARAADDRLGVPLNASAGTTVIDYAQPNVAKEMHVGHLRSAVIGAAMVEILEFTGEKVIRRHHIGDWGTQFGMLIQYLLEHPHELDHKSAGDDEQASGEEAMSNLNRLYKASRALFDSDEEFKTRARARVVDLQAGEAETLALWQRFVDESKIYFYSVFNKLDMDIQDPDVVGESGYNDMLVETCKLLEESGVAVRSNGALCVFFEDVKGPDGNPTPLIVQKSDGGFGYAATDLSAIRDRVTNLGATELIYVVDARQSLHFKMVFETARRAGWLNDDVKAVQLAFGTVLGKDGKPFKTREGETVRLVDLLDEAIERASAVVREKAQDLTEAEIAERGAQVGIGAVKYADLSTSAARDYKFDLDQMVSLNGDTSVYLQYAYARIQSILRKAGDATPAAHPEVALAPTERALGLHLDAFGELIAEAAAEHAPHKLAAYLYQLASLYTSFYSECPVLKADTPEQVENRLFLCELTARTLSKGMSLLGIRTPEKL
>NZ_CP018870|4198340:4255558|4253346_4254267_+|WP_030026275.1|DBSCAN-SWA
MTTADGVVGQGPAPEAAGKVRAFLRLVMIEHSVFALPFAYIAALTAMFQLDRTVHWGRLLLVTVCMVGLRTFAMAANRIIDREIDARNPRTAGRELVTGAVSVRSAWTGAGIALVVFLGSAALLNPLCLALAPVAVIPMVVYPYGKRFTDFPHAILGLAQAMGPVGAWLAITGEWSWDAVILGLAVGVWIGGFDLIFACQDVAADRAEGVRSVPARFGVPAALWGARGSHVVTTALLAWYALATDAGPLFWAGLAVVVAAFVYEHTIVTPHDLSRLNRAFFTVNGFIGIALFVCALADLVVRGLTV
>NZ_CP018870|4198340:4255558|4219603_4220176_-|WP_045321416.1|tail|DBSCAN-SWA
MSRAAVPGLPSRHPIGGQLPALYADDDFAQRFTAGLDTVLAPVFTTLDNLPSYFDPRLAPADFLAWLAGWVGAADDPDWPTALRREAVARAVELHRWRGTRRGLVEALRLVLGVSADVSGDGTAVWSRTAGSEPPPPPAGEVLVRVWPRGPGAAYEVDADRVRALVHSLCPVHTACRVEILPGPPTAEGS
>NZ_CP018870|4198340:4255558|4232049_4234167_-|WP_075972155.1|DBSCAN-SWA
MHPPAPEQAAGPDRDGTADGELPYLWTRLRLVEERVRLAVRLRRAADPDPDDPYRGQYLTPEAVDRLLDGEPAADLPALAAAGPPPPGSPLDVLATRFGLEPPDVDLLLVALAPDLDARFERLYGYLNDDLTRRRPTVGLALELCGLGQAPAARFRLAPGAPLVAGGLLEVTEPERPPLSRVLAVPDRVTAHLLGDRAPDPQLAEVLGEAADDPAVDPEELHRAAAAAAGGTGHVHLRARGGDPEGLAAAALRARGLHPLVLDPSALTRHARALPALARAAAREARLLGAGVLLGPLEELPDHPGERAHVLRTLCTALSGIPLFTHGASGWEPAWAPATPVSLTVAAPSPDRQAVRWRHALERAAAEHGNHGEGGGADMLARSVSAHRLDAGQLRRAADTASRTAALDGRPVSPADLRAAVRAQNGAGLARLARRVEPAVGWDDLVLPAPTHRRLRELAVRARHRDQVLGRWGMRPGGGRGRGVIALFAGSSGTGKTMSAEVVAADLGMDLYVVDLSTVVDKYVGETEKNLERIFTEASAVNAVLLFDEADAIFGKRSDVKDSHDKHANMESAYLLQRMESFDGIAVLTTNLRANLDEAFTRRLDVIADFPVPDAAQRRALWERCLGDRLPRADDVDLGFCATRFDLAGGSIRSCAVTAAYFAAASDGPLTMRQVVTAVAQEYRKLGRLVLEGEFGPYLGQVTDV
>NZ_CP018870|4198340:4255558|4245804_4246566_+|WP_030026259.1|DBSCAN-SWA
MLAAEATGVNETVLNGALLLALPIALLAGLVSFFSPCVLPLVPGYLSYVTGVSGADLAEARRGRMLAGALLFIAGFTAVFVSTGALFGFFGQTLRENNEIISRVLGAVVILMGLFFMGAIPGLTMREFRFHRKPAAGLLGAPLLGVLFGVGWTPCMGPTLAAVTTLSLDQASAGRGALLTVVYCLGLGVPFVLAAIAFRKALGAFGWVKKHYAWVMRIGGGMLILTGLLLVTGLWDSIVTDMQAWTQSFTVGI
>NZ_CP018870|4198340:4255558|4217546_4218308_-|WP_075972154.1|DBSCAN-SWA
MPARAAAPRPVVRPLPAADNVTGAPCPACGTPNPPDRRFCRRCATPLTPTTVAAPLPWWRTVWPLRRRTRAGSGRLVRFLVVLAVVLALGAAGFLLLPAGRHLVQDTLDKLGKAKAVTPTRAQAGAELPGHPVGQSTDGLSNRYWAAPGPGASATYTFGKPFRLVAVIVTNGASPAPEEYARQGRALRIDMEVTDRDGTTVHKELHLSDKPGPQTFPTGISDVATVRLTLQEPAGSAPQHHLALAEVEFFQRG
>NZ_CP018870|4198340:4255558|4222936_4224754_-|WP_030028901.1|DBSCAN-SWA
MSGSEPGGRSFAADPIVEAPGELPQIWAAQLVSCVVDENVGLPDTAVLTYRDPDHEFLRATGVTIGTPLRVSVATVKGQSRERLFNGEVTALEIDRDRTGSFTVVRAYSKAHRLQRGRKVVAYRNMTAAAIVRKVAAGAGLAVGKVEAAPVTYKQLSQANVSDWDFLQYLAGESGAHVRVDDKGLLQFTRPVQASGAPAPSTSAVRDPMVLEYGRNLLALRAALTAADGASKVQVRGWDVTTKRPLVAEQPSVVSDTVVPGLGPQTAARFGAAAVAVTDTPYRTQAETTAVAKAAAAQISSGFGELEAVAEGNPLLRAGKPVALGNVGQAFSGRYTATAVQHVLEPHGGFRTTVWVSASPDRSLTGLVAGAGVPARGGRIPGLAIGVVTDVREPNGSQRGAVRLKFPWLDDTYTTDWVRTVQWGGKGGGGVVSPEVNDEVLVGFEQGLLDSPYVIGGLYNGVDQPSPHDVPLVDKTSGKVNRRSIVSRSGHRVELLDAAAPGPSGLRLVTGDERLEVRMDDRRDRIELTVYAGRGRPLTSVLLDKDGITLDARKGTVKVSGRQVDIDGTAGVRIGGRSVKVSGTSDVTVDGGLLAVLKARLIRIN
>NZ_CP018870|4198340:4255558|4216286_4217513_+|WP_075970813.1|DBSCAN-SWA
MERKAAPAAPRTSAVDLLVQAFLALFGRRFRTLLTMVGISVGLAAALATLGITASAAGAVSDQFDALKATRVTVKYPSEPVAGIRPRPDGGDTERVRGLNGVRTAGLLSKAGEQPVVSRLRSGTSNDLPEGTVLAAQPDALLAMSAELTQGRWFDTGHDARRERVALLDTAAASRLTVDGGAGNSVIHLNGVPFSVVGVFRAPSGDTNLTGSVVVPYWAALQDPAGLGFAPAEMIIRTDLGAADQIGAEAPFALAPGAPDKLVALVPPDPRSLRQGVESQTRALFLGLAAVSLGVGALGVSNTAYVSVLERRSEIGLRRALGASRRAVAGQFCIESGLVGLAGGVVGTVLGIQITAVTCLAKDWLVVLDPALTSAGPLVGLVVGLAAGLYPALAAARILPAETLRAGV
>NZ_CP018870|4198340:4255558|4229752_4230193_-|WP_030031999.1|tail|DBSCAN-SWA
MAEGDALSTHIFGVQLGGYLVESIQEISGLTVEEEVVEVRQVSAEGKQIIRKQPGARQAGEVTITRGLDKSSEFTKWIKETLNNGAVDTARQNLTIEIKDSTGATIRRIQLMQGWASKWEGPSLKAGESAAATESVTIVFEEIIVE
>NZ_CP018870|4198340:4255558|4251419_4252877_+|WP_045321402.1|DBSCAN-SWA
MAYDDLRSLLRALEREGDLKRIKAEVDPYLEVGEIVDRVNKAGGPALLFENVKGSAMPLAMNVFGTDRRLLKALGLKSYAEISEKIGGLLKPELPQGFIGVREAFGKLGSMVHVPPKKVKGGSAPVQEVVLTGDDVDLDLLPALFTWPKDGGSFFNLGLTHTKHPETGVRNLGLYRLQRHDKRTIGMHWQIHKDSRNHYAVAAAKGERLPVAIAFGCPPAVTYASTAPLPGDIDEYLFAGFVAGKRIEMVDCKTVPLQVPANAEVVVEGWLEPGEMLPEGPFGDHTGFYTPQEPFPALKIDCITMRKRPLLQSIVVGRPPTEDGPLGRATERFFLPLLKIIVPDIVDYHLPESGGFHNCAIVSIDKKYPKHAQKVMHAIWGAHMMSLTKLIIVVDKDCDVHDLHEVSWRALGNTDYSRDLTVVEGPVDHLDHASYQQFWGGKAGIDATKKLPEEGYTRDGGWPDMVESDPATAALVDRRWKEYGL
>NZ_CP018870|4198340:4255558|4243847_4245083_+|WP_075970820.1|DBSCAN-SWA
MRDDRGVSRRGLLGLGLGAAAAMGVAGCGLPDVSGPGAPGPVKTPKPGERPPGKPIGDGSTADTGPQPHQPDRPVPLQPGETPPQFVVFSWDGAGEVGNGLFPRFLKLARDHGASMTFFLSGLYLLPESKRSLYRPPNNPVGASDIGYLKDENIRATLACVREAWLDGHEIGTHFNGHFCAGPGSVARWTPADWENEIDQAVSFVTGWRTNTGFTDLQPLPFDYRRELTGARTPCLLGRDGLLPTARKLGWRYDSSSPGGLQVWPERRSGVWDLPLQSLPFPGHSFEVLSMDYNILANQSKNTTRGVPANYPAWRSQATATYLGGFRRAYETNRAPLFIGNHFEEWNGGIYMDAVEEALKGMADKKDVRLVSFRQFTDWLDVQDPKVLARLRTLGPGRSPAGGWNTYLTAA
>NZ_CP018870|4198340:4255558|4229258_4229756_-|WP_030032001.1|DBSCAN-SWA
MRRRTVTAGSLEEILQVTAPAQTPEQAAVPPAAAAPAPREDHGLRTEFEFELPRGYVDDAGTVHRHGAMRLATARDELRPQIDLRVKENPAYLSVVLLSQVITRLGTVTDVHAGIVERMYATDVAFLQDFYRRVNSEGHTRAAVTCPHCDGGFEVDLSGGRLGES
>NZ_CP018870|4198340:4255558|4200352_4202092_+|WP_075970806.1|tRNA|DBSCAN-SWA
MAQSAQSSTETDWVSRFADDVIAEAERRAPGKAVVVASGLSPSGPVHLGNLREVMTPHLVADEIRRRGHEVRHLISWDDYDRFRKVPKGIPGVTEESHARHIGRPLTAVPAPEGSAYPNWAEHFKAAMAESLAELGVEYDPISQTEQYTTGVYREQILHAMKHRGDIDAVLAQYRTKAKPGGKKPQQKQVDEAELEAAEGSGAAAEDDGSAGEGGYFPYKPYCGQCGKDFTKVTSYDDETTEMTYVCTEDEFTETVKLSEFNRGKLVWKVDWPMRWAFEGVIFEPSGVDHSSPGSSFQVGGQIVHIFGGEQPIGPMYAFVGISGMAKMSSSKGGVFTPGDALKIMEPQLLRWLYARRRPNQSFKIAFDQEIQRLYDEWDKLEAKVADGSVLPADAAAHSRAVRVASHELPRTPRPMPYRTLASVVDITAGHDEQTLRILSDLEPDKPLTSLDEVRPRLDRAENWITTQVPADQRTLVREDPDTELLTSLDDEGRESLRLLLEGLDSHWSLDGLTTLVYGVPKVMAGLEPDAKPTPELKVAQRTFFALLYRLLVTRETGPRLPTLLLAVGADRVRKLLAV
>NZ_CP018870|4198340:4255558|4212672_4213056_+|WP_158879852.1|DBSCAN-SWA
MLSKRISAGFIAMAAVAGVVAAAPSASAVDRTCYDGNFCIYKDRDYSTNNSMYRTKYESARWDIDMPAVYEADSSWWNRRGQSSKTYGGRWMSLGVEICLIPGGSVNYYWDANDDGASNTLNDGSRC
>NZ_CP018870|4198340:4255558|4250984_4251329_-|WP_030026269.1|DBSCAN-SWA
MLRYLPFLLIIALTIYAFIDCLNTPEEEVKHLPKAMWVLIILLFSVVGPVVWLFAGKKRVASGGGRGPRGRGQWVAPDDNPEFLKSLREEQENKDREDRDKGRDKDRDKDKDSD
>NZ_CP018870|4198340:4255558|4250624_4250942_+|WP_107069566.1|DBSCAN-SWA
MTALATPSRGSSELSTWHVDMPAGATGPEHSVSREQVWTLTAGSLEVTCGDRTEKVTAGRTLVLPADAPRRIHAPEAFQAYVAMRADGVVTVTGEDGTRVLPWAR
>NZ_CP018870|4198340:4255558|4225591_4226017_-|WP_030028899.1|tail|DBSCAN-SWA
MTDNIFATSVFFRLAIGGDDLGAFHTCSGMGAEVEMESYAEGGNNGFTWQLPGRVTWSNITLTRPVTADTAKIGRWLDETLRRVEPKDGEIVALRPDLSRIISWQVFGIVPVRWQGPSFDPANSAAAVETLEIAHAGLLPS
>NZ_CP018870|4198340:4255558|4249997_4250471_-|WP_045321403.1|DBSCAN-SWA
MFRVTRDDYADVELTFLLGLGFQLVLGEFTRRLAEVGQGDLRPVHGMAFQALKGGGATATELAERLGVTKQAAGQIVDDLEARGYVRREPHPEGGRRKLVVLTGAAREHLSVAGRVLHRLEDELAGTADLAALRRELGHVVRALHGVDGLPPLRPVW
>NZ_CP018870|4198340:4255558|4241624_4242947_+|WP_030026252.1|DBSCAN-SWA
MAGVSYPYPYEAPVSQTLFERASLVTPGGVNSPVRAFRAVGGTPRFMVSGTGPYLTDADGREYVDLVCSWGPMILGHSHPEVIEAVQAAVARGTSFGTPGEGEVALAEEIVARVAPVEQVRLVSSGTEATMSAIRLARGFTGRAKVVKFAGCYHGHVDALLAAAGSGLATFALPDTPGVTGAQAGDTIVLPYNDLEAVRAAFAAHPGEIACVITEAAPGNMGVVTPAEGFNQGLADLCRENGALYVSDEVMTGFRTSRAGWYGVDGVRPDLMTFGKVMGGGFPAAAFGGRADVMGHLAPAGPVYQAGTLSGNPIATAAGLAQLRLLDAAAYEKVDAVSAQIQSLVTGALAKEGVAHRLQTASNMFSVFFTEDVVRDYDDAKKQESFRFNAFFHSMLAQGVYLPPSAFESWFVSTAHDDKAIERVAAALPAAARAAAEATA
>NZ_CP018870|4198340:4255558|4230278_4231844_-|WP_075970816.1|tail|DBSCAN-SWA
MPTYLTPGVYVEEVQSGARPIEGVGTAVAAFVGFAQSGPFHEPTLVTSWDQYSQHFGGFTEGAYLPHAVYGYFANGGGAAYVVRVGGSDRAGASAGPAAAGAVPPPRAAEPVELGGFLITARPGVTGVSVEIADADGENPPEDRFKLLVRQGEQVAETFEASARKNVKGYLVTQARASKLIEVTEQRSAAQTRPAVQSLAVPDALPAVPAATGGTAVSRLDPAEYVGDAGARTGFAGLETIDEITMVAVPDLMSAYERGDIDSEGVRTVQLAVISHCEQMGDRVAVLDTPPGLTAQQVRTWRNDEAGYDSRYATLYYPWVRVFDPAAGRNTTVPPSGHIAGVWARSDAERGVHKAPANEVIRGAVDLELRLSKGEQDLLNPIGVNCVRAFPGRGIRIWGARTLSSDPAWRYLNVRRLFNYLEESILLGTQWVVFEPNDDRLWSSIRRNVTAFLTEEWRRGALFGRTAAEAFYVKCDRDNNPQESIDQGRVVCEIGVSPVKPAEFVVFRLAQFSDSTSLVDE
>NZ_CP018870|4198340:4255558|4222145_4222568_-|WP_030028903.1|DBSCAN-SWA
MSERFIGRGWAFPLRVGPTGGIAMVDRERELEEAIRLVLGTAPGERPMRPDFGCGIHEYVFAPGDGDTAGRVAQQVREALERWEPRITVDDVVVAFDAVEAGTLYIDVHYTVRTTNDRRNLVFPFYTIPSEEGTEEMVAD
>NZ_CP018870|4198340:4255558|4213127_4214072_+|WP_159393532.1|DBSCAN-SWA
MNKRIRVVTAIAVAAVLTGSVSACSEESPKDMETARRAQAALDSANEALEQEREAETKLIRKCMNDQGFKVFPSDGANSSKAGKRSEDLTPTPETARTVGYGADPRRSDNQKTQEVGDDFDALPEDVKRAHSMAMDGYVDKPEGGVEFDFGGGKVMVPSKGCRGETLKAVYGDVKEYLRLNWTVYNTVKQDSAHILADDDAYQKALSEWASCMKAGGYPEIPTPEKAREAALSHYANVADGDTVALDNAQRAEIKQATTDADCGTKVGLNTKAREAKSKASADSLVKHEAEITAWLELVTKAKGRAQELLRETS
>NZ_CP018870|4198340:4255558|4208787_4209516_-|WP_030029772.1|DBSCAN-SWA
MNGPGIQLTLAPELRLFAPPSRRTDRVPTATDGASSLGHVVESAGVPLTEVGRLLVDGQEVATSYVPQDGQNVEVLGVERPQHVPGAPLRFLLDVHLGTLARRLRLLGVDAAYENEDIGDPALATRSAAERRVLLSRDRGLLRRREIFAGAYVYSDNPDEQLRDVLSRFAPALAPWTRCTACNGPLHEADKESVGDRLEHGTHRSYDVFAQCTECERVYWRGAHHARLERIVDEALVEFGTA
>NZ_CP018870|4198340:4255558|4224750_4225479_-|WP_030028900.1|DBSCAN-SWA
MASSASRASRARAQLTLKEPPASVGAKPGGTIARLDLQFNPSTLQLGKTTEWRRSPSRMAGQSALPEFVGSGPRTLSLEVFLDATATHDNSVEQAVEKLMKACVPTPASLGRKKPASPWVRFEWGSARTTSFDGVLSNLSVSYTLFDVDGKPLRATCSLSIEEASVDPPGQNPTSGSRTARSTHTVVAGDSLAMLAWREYGDATAWRVIAEANGMDDPMALVPGSEIVVPGVRDQYGEEEQR
>NZ_CP018870|4198340:4255558|4252873_4253347_+|WP_030026272.1|DBSCAN-SWA
MSPIAVEGPELNLGTAQAYVVLARPKIDPTQPGVIAAAREAGVSPEEFAGPGDVWALMYDADGDGDGFELPGARDTEADAFAEQVQQALAAAEPFTVEAGNFLRLDARPAGADWTVTAHITPPEGDEDGPAARTLELGALPAAELLAELERFRGELA
>NZ_CP018870|4198340:4255558|4203631_4204399_-|WP_045321423.1|DBSCAN-SWA
MHRSASRLTRVLACAAVPVILTVAGCSSDSGKDSASKGDKKSGSSASSKPGEKAKKPELEKAAFAALPDPCKAIQTATIETLVPEAKDKNGTATKSNDLATRASCSWNGLDEDGLKGSQYRWLSLSFFRTDSHASLGSANKRAEEQYGKQVEAAKATEGAQNVKAEPVEGLGDQGTSVVYSVKKDVDFFNTTVVARSQNVVVTLDYNGAAYEGAGAPDQAKLLQDALTAAKEAVASIGTANKPAEQPQPESPQPQ
>NZ_CP018870|4198340:4255558|4242943_4243648_+|WP_030026254.1|DBSCAN-SWA
MSQDGRDPKPASDLTVVHLVRHGEVHNPDGVLYGRREGYHLSDLGRRMADRVAEHLRSRDIAYVVSSPLERAQETAEPIAKAHGLDLATDARLLEAENVFEGKTFGVGDGALRKPGNWKHLTNPFKPSWGEPYVEQVVRMMSALEAARDAARGREAVAVSHQLPIWIVRSFAEKRRLWHDPRRRQCTLASLTSFTFQGEKLVSVGYSEPARDLVPAHLLAGAKPVKGASKAFGA
>NZ_CP018870|4198340:4255558|4238274_4239006_-|WP_078848871.1|DBSCAN-SWA
MRCADTNSPVPTSPAHAPRPHAPAPAPAPAVPRRTGRRVTVAVYASDPILRVGVVHQLRQRPEIELVPDLDADTAQVSLVTVDSVDDETAALLYRLRHNPDTRTGLVVGTFESGDALQRAIECGVSAVLRRAEADQDRLLRLVLAIANGEGVLPGDLLAKLLDHVGSLQRSALDPRSVSLSTLTAREADMLRLVSEGLDTAEIARKTSYSERTVKNVLHEVITRLQLRNRTHAVGYALRNGLI
>NZ_CP018870|4198340:4255558|4226051_4229099_-|WP_075970815.1|DBSCAN-SWA
MAWRDRLRRRAAVPDPGASAAAVTAPDAGGAAGAGVPAAVPGDWDGGWRMTAPPALTVSRSAAGVSDGLAFRSGLAAWRDPSFDTGLGHGLLPSAPAGLVRGVAGPATARPTHSGGGPLLLRALPTAPGAEPEPGAGHGPAPARDTRHAQHPPHISRRTRPGAASPSPPASAPDAVRPTPAAGHDANSGAPGPVVSRAVARPDAGPPASRPGRPVTSPDPETPSTSGTAASVARGAAAPGRPSAASGTRDLAATRSAAALGASAPAVQRATAPSAQTGRTAPTPASFPVVRRIAVVPGASAEGPAGAPVQRTAARTQAQAGRTGEGAATTVRPRPVGRTLTTARVPAAPRRHVPAVRPSATPGTAPSAAPDTVLPDASVQRARTRAPLGSPLPELPPAEPPSSPVATPPAPAMPTVQRQAEPSGAAPAAADAPLQRTGSPLTAPPSPAPAEPPAQRMRTRAPLGEAPPTPHDRTPSAVTPPTPTAATPAPALPTVQRQADPTASAPAATPAPALPQVQRHTEPAATAPTPGSPAQRTPAPHTETPPAPAAAQRMRTRAPLGEPLTQLPPTAAPVTPAPAPALPHVQRHTEPAATAPTPGSPAQRTPAPHTETPPAPAAAQRMRTRAPLGEPLTQLPPTAAPVTPAPAATPAPAALPTAQRPADPAPSSAPAAAAPAQRMRTRAPLGEPLTQLPPTAVPANPPSGPRVRSGLGAPLPSMPARAAVPAAPTAPSAAKGPAGARPPVQRATASPRRSGPVPLVAARAVAGAGAARGAPASLQLLAARPLTLGTQDAAGMGSAPAAAPRPASRPVVPARWATPSAPSAASAASAAAPQQPVQRASAPAARTPAPGPGPRPAHAVHAAHAVRPAPAAAARATATPLPVTGPYTSPLVVQPAPAAPVAGSVPVVRPRSSAPAASPQAPVPVPLPPTAPPPPVQRDTGGGRTGSGPLGPARAHPGGTTAGRPDGARDAAASGGADLDLDDLARRLLDPVARLLRTELRRGRERAGRPFDGRR
>NZ_CP018870|4198340:4255558|4209577_4209994_-|WP_030029771.1|DBSCAN-SWA
MATSTAAARREEARTAYDAFLRECPTSQLLARISDKWVGLIVSALGEADDRSMRYSDLGRRIPGVSQKMLTQTLRSLERDGLVTRHVTPTVPVRVDYRLTDLGSSLGCLLSSVKTWAENHFDEVNAHRAAYDRSTADA
>NZ_CP018870|4198340:4255558|4222567_4222885_-|WP_030028902.1|DBSCAN-SWA
MPAAARTGDPTNHGGRLATPPPGAAAAVATVLIGGRPAAVVGSLHVCVVPPHAALGPANVIVPNPAALTSGTVLIGGLPAARARDQTTCGAQVLTGAMDVLIGGM
>NZ_CP018870|4198340:4255558|4234175_4234886_-|WP_030033413.1|DBSCAN-SWA
MIHEVDEGLRRLLAESGLEASGVEVVFDAPTRDWAARRSAPTVCVFLYDIREDPTRRGSGTGVVYDADGFVVARRTPPRWFELTYLVTAWAGRPQDEHRLLSQVLACLVSTDTLPPRLLTGTLADLGLLVDVDAGGTGMDAPAASDVWSALGGELKPSLGLRVKAPLAGIDRVTAQPVTQGLVVDSVPQAQPDGDAGGSPRRLRYVELGATGPEGFGGSRERPGAPARRRRGERQP

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_030028041.1|4198340_4200110_-|tRNA	arginine--tRNA ligase	M1PAX3	Moumouvirus	9.4e-76	31.4
WP_075970806.1|4200352_4202092_+|tRNA	lysine--tRNA ligase	NA	NA	NA	NA
WP_045321424.1|4202179_4203499_-	DUF2637 domain-containing protein	Q6VY65	Streptomyces_phage	1.4e-79	69.6
WP_045321423.1|4203631_4204399_-	DUF3558 family protein	NA	NA	NA	NA
WP_107484917.1|4204512_4205376_-	hypothetical protein	NA	NA	NA	NA
WP_075970807.1|4205608_4206802_+	RtcB family protein	A0A1I9SAD2	Rhodococcus_phage	1.4e-123	57.9
WP_030029775.1|4206936_4207701_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_030029774.1|4207763_4208099_-	YnfA family protein	NA	NA	NA	NA
WP_030029773.1|4208206_4208719_+	hypothetical protein	NA	NA	NA	NA
WP_030029772.1|4208787_4209516_-	hypothetical protein	NA	NA	NA	NA
WP_030029771.1|4209577_4209994_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_075970808.1|4210140_4211037_+	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_075970809.1|4211148_4212159_-	quinone oxidoreductase	NA	NA	NA	NA
WP_158879852.1|4212672_4213056_+	hypothetical protein	NA	NA	NA	NA
WP_159393532.1|4213127_4214072_+	hypothetical protein	NA	NA	NA	NA
WP_075970811.1|4214079_4215579_+	hypothetical protein	NA	NA	NA	NA
WP_075970812.1|4215571_4216246_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.1e-27	39.8
WP_075970813.1|4216286_4217513_+	ABC transporter permease	NA	NA	NA	NA
WP_075972154.1|4217546_4218308_-	zinc ribbon domain-containing protein	NA	NA	NA	NA
WP_045321416.1|4219603_4220176_-|tail	phage tail protein	NA	NA	NA	NA
WP_075970814.1|4220172_4222146_-|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_030028903.1|4222145_4222568_-	GPW/gp25 family protein	A0A1D8KT65	Synechococcus_phage	2.9e-07	30.8
WP_030028902.1|4222567_4222885_-	hypothetical protein	NA	NA	NA	NA
WP_030028901.1|4222936_4224754_-	VgrG-related protein	NA	NA	NA	NA
WP_030028900.1|4224750_4225479_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_030028899.1|4225591_4226017_-|tail	phage tail protein	NA	NA	NA	NA
WP_075970815.1|4226051_4229099_-	hypothetical protein	NA	NA	NA	NA
WP_030032001.1|4229258_4229756_-	hypothetical protein	NA	NA	NA	NA
WP_030031999.1|4229752_4230193_-|tail	phage tail protein	NA	NA	NA	NA
WP_075970816.1|4230278_4231844_-|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	8.3e-68	34.4
WP_075972155.1|4232049_4234167_-	ATP-binding protein	A0A0R6PCP6	Moraxella_phage	4.9e-23	31.7
WP_030033413.1|4234175_4234886_-	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_075970817.1|4234882_4238029_-	hypothetical protein	NA	NA	NA	NA
WP_078848871.1|4238274_4239006_-	response regulator transcription factor	NA	NA	NA	NA
WP_075970818.1|4239250_4240561_+	hydrolytic protein	NA	NA	NA	NA
WP_030008917.1|4240873_4241311_-	hypothetical protein	NA	NA	NA	NA
WP_030026252.1|4241624_4242947_+	glutamate-1-semialdehyde 2,1-aminomutase	NA	NA	NA	NA
WP_030026254.1|4242943_4243648_+	histidine phosphatase family protein	NA	NA	NA	NA
WP_075970820.1|4243847_4245083_+	hypothetical protein	NA	NA	NA	NA
WP_075970821.1|4245161_4245788_+	TlpA family protein disulfide reductase	NA	NA	NA	NA
WP_030026259.1|4245804_4246566_+	cytochrome c biogenesis protein ResC	NA	NA	NA	NA
WP_045321405.1|4246579_4248328_+	cytochrome c biogenesis protein ResB	NA	NA	NA	NA
WP_045321404.1|4248324_4249407_+	c-type cytochrome biogenesis protein CcsB	NA	NA	NA	NA
WP_030026264.1|4249432_4249948_+	hypothetical protein	NA	NA	NA	NA
WP_045321403.1|4249997_4250471_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_107069566.1|4250624_4250942_+	cupin domain-containing protein	NA	NA	NA	NA
WP_030026269.1|4250984_4251329_-	membrane protein	NA	NA	NA	NA
WP_045321402.1|4251419_4252877_+	menaquinone biosynthesis decarboxylase	NA	NA	NA	NA
WP_030026272.1|4252873_4253347_+	hypothetical protein	NA	NA	NA	NA
WP_030026275.1|4253346_4254267_+	4-hydroxybenzoate octaprenyltransferase	NA	NA	NA	NA
WP_078848869.1|4254348_4254936_+	Uma2 family endonuclease	NA	NA	NA	NA
WP_030026278.1|4254952_4255558_-|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA

Sequences of DBSCAN-SWA_4

Nucleotide sequences of DBSCAN-SWA_4

>NZ_CP018870|7505840:7577592|DBSCAN-SWA
GATGGTGGCGGCGCACGAGCTCGGGCACGCGCTCGGTCTGTGTCACAAGTCGGGCAGCGGCAAGAATGCCGTTTCGTCGGTGATGTGGCCGGATGTCGCCCAGTATCCCGACGCCCCCACCGACGTCGACAAGGCCAACGTCAAGAAGCTGTGGGGATGATCATGGGCGTGAAGATGTGGGTCGGCGGCTGCCTCGTCGCGGCTGTCGCCGCAGCGGGCGCGGCCTGGTTCACCACCGCCCCGGAGACCGGGACCACGCATGCGGTGTGCGGACCCGACCTCGGCCGGGACGACGTCGTCGCCGCACGGTCCCGGGCGGTGGCCGTCGTGGAGGCGGTCGAGAACACCCGCTACCGGGAGGACGGCGGCAGCGCCTACCTGACGACCCGGGTGAAGACCCTGGAAGCCTTCAAGGGAGAGTTCGGCGACGTCCTTGAGGTCACGCAAGGGGTGAAGAACGGCGGCAGCCCGGGCCGGTACGCGACGGAGGATCCGGACCGCTACGCGGTCCTGGAGCCCGGCCGCCGATACGTGATCGCGGTCCAGTCCGGATCGACCACGGGCGCCGCGGGCACCGAGGCGTGGGCCTGGTACGCCGAGCCGGCCGAGCGGGGCCTTGTGGGGGAGCGGGAGCACTGGCAGGAGGCGATCGCCACTCCGCCCGAGACGGCCGCCTCCAGCGCGTGTGAGGACATCGACGCCCCCGCAGGCTGACCGGGCCGGCGCCCGTCGCGTCCGTGCACGAGGGCGGCCGACCGGCGACGCTCCGCAGACGGGTACGGGGACCTCGGCCATCGGCGGGGCCATCGCCCCGGCCGGCCGGGGGAGAGCACTCTGTCCGGGTGGCGCTCACCCCTCGCCCCAGCGTGGCAACACCCGGCCGCACACGGATACGGGGTGCAATGGCGACTGCTGTGGAGCCGCCCCTTCGGACGGACTGCTCCCGGCCCCCGTGGCGCTGTCGACCGCGGGCAGGCCCGGCTGCCGTCACACGTCGCCGGTACCGCCCGGTCGGCAGCATCCACGCCAGCCCCGCCCGTGGCCTCTGCCCGCTCCGTACGACACCAGCCACGCCCGGCCTCGGCGGCACCGCGCATCGACGCCTGCCCGCAAGACTCTCCGTGACTGTCCCGCCCGTCCCGCAGGCGTGTACGGAACTGGACAGGGCCCTTTCGGCGGCGGTTCGTTGAACACGTCGACGGGAGGGGAGTCTTGTGATGGACAGCCGTGCGACCGCCATGACGACCGCGACGGGGCCGGAGTGGCAGCTGGCCGCCGCGGCGGGTGGGGCTCTGTGCGAAGTGGGCGCCCTCGCGGCCGCGCTGCAGGAGGGCAGGTGGCAGGACGCCCGCCACACGGTCGACGGCTTGCGTGAGGCGCTCTCCCGACTCGACACCCTCCTGCCCCAGGTCCGTCCGACAGCCGAGAGGACCCGCAGGCTCTTCCCGCGCCAGAGCGTCTTGATGCCCTGCTCGAGGCGGTCGGACCCGTTAGCCCTGGTGCGCACGCTCCTCGGGCGCGGCAGTGTCGATGCCTTCCCTGCCCGCCAGCACCGGCGTAGCGGGTTTCGAGCCCACCGCTCGCAGCCGTCTGGCGCAAGGTGGTGGCCCGCATCCGACGGACGACGCCGCCTGCACGGTCCCGAGCCCCGCCTGGCCTTGTGGGGCCGGGTTCCGGGCTCTTATAGGGTCGCGCACATGACCGATGCCATCCCCACGAATCCGCAGGAAGAAGCCGCGCAAGGCCGCATAGCACTCTGGCTCGCAGCAGAGGACCTCGGGTGGCTCGCACGCCACTGCTGTTGTCCAGAAGACGCGTCACCCGATGAGAAGGACCGGTGCAGCCGCCTCCGATTCCGAGCGAGCACCGCCCTGTACAAGCGCAGCCAGTCCCACTGACGCAGCTTGACTCACGGCATCACGGCTCCCTCGACTGACGACATCCCAAACGGTCAAGGCGGGACTAAACGCCCTTTAAGGCGTCGTGGTGAAGGCCCGCAGGGCAGCGCCGCCCCGTAGAACACCCGGCCGGACCGCGGCGTGGACGGCCTCGATCACCAGCCGTTGGTCACTCTGCCGCATCATCGTCAGCGGAACCTTGAGCTCCGGTTCGCCGGCCTGACGGCAGCGGATCACATACCCGAGGCGCCCCGCCTCCTCCACCTCGACGCTGTCGAGGTCGGCCAGCGCTAGCCGGTGTGGCGTGAGGCCCCGGGACACGGCGATGTATCCGTCCGCTATTGAGACGGCGAGGAGCCAGCGCAGGGCGAAGGCGCAGACAGCGAACGCGGCCCCGAGGGCAAGGTAGACCGGCCTCGGCAGCACCTGGCCGTTGCTGGTGAGACCTTGGTTGAGCGCCACGAGAACTGCGGGGGCAGCAAGCACCAGGAGGCGGCGTGGGTCAGGGCGGACGAACACGGACTTGCTGTGCGCAGGCATGGAAGGACTCTTCCCTCGAGACGGCGGTGGTGGTGGGGGCGAGACCCCCTCGGGGCCGACCGGGTCCAACCCTTCGTCACGCACGGAGCCTGGTCAAGTTCTCGCTGGCCGCGCTGTGCTGGCAGGAGGCGCAGTGAGCGCGTCGGCGCTGCGGCACGACCGTGAGCGGCGCCTCCAGGGGCGTTGTCGGTGGCGGCGGGGACCATGAGGAGATGAGCGCGGGTATCGCGCCCGACGGCCCGCACACGGACATCGACGGGCTGTGCGAGCAGATCCGGGGTTCCCTCGCAGGGTGGGCACCCCGCCTGCTCGGTGTCCATGTACCCCGGTCCGTGTGCGGTCCGGCCGAGGTGGCGCGGCTGGTCGGCGCAGTGGCCAACGCCGCCGAGCTCACCGGCCTTCCCCGCGACGGCGCGACCGCACGGGCGGAGCTGCACACGTCCGCCGCCAGGGCATCGGCTGCCGGCGAGCGGGCGGGGGCGGACGTCCGCGCCGAACTGACCGCAGTCCGCGCCGGGTGCCGCCGGGCGGCCGTCGCCCTCGGCCTTCCCGTACCCGTCACCTTGTGACTCAGGCGGTCTGGCCGGCACCGGATCTGCCCACTGAACGAGCGTGGTTCATTCTTGACCTACGGTTTGGCGACGTGGTGGACGTGCCCGATCGGCGAGGCGCTGCGCCTGCTGCTGGCGACGCTGCCACAGGCTCCGCATGCGGGAGCAGCGGCATGGCGTATTCCAGGACATCGTCCCGCGCACCGGATCCTATGCGGCTGCCTTGGACCTCCGGCCTTGATTGCCGGACTCCGGCCAACGGAAACGGGGGAGACATCGCGCGGGCAGGGGGCCCAACGGAAGCGGTTGGGCAAGGCCCGCTGCTACATCGCGCGCAGGCGTGAGCCGGGTCGGCCGTGCTCGTTCGCGAACCACTGCGCGATGTCTTCGACGGGGTCGCTCGCGGGCCGGTCGGCGAAGGTCTTGTCGTAGGCCGTCCGGCCGGCGGCGTCGACATATTTCGGAGGCTCGGGAGGCAGCCGGTCGGCTCGAAGCCAGCGCCCGACTACCGGTTCGATGGTGATTGACACCTGAAGCGGGAGGCTGAGGCCGCCGGTCTGCTCGACCGTGAGGGCCAGCGCGTGGGTCGCGCGGTTGCGTACCCACCGGGCCCCGCGCATCGCGTCCCCTATCGCCCTCCTGCGGACGGTCCTGTAGCCGCCGTCGGAGGTGAGCTGCTCATCGAGAACGCACGCCCAGTAGATGGTCTCAGCGGCGGGGATCGCGACCGCGTCCGTGCTGGCGCCATGGGCGGACAGGCACTCGCCCAGCCGGGCTCGGGCTTGATGGAAGCCGTCGAAGGCGAGCCTCAGGAGGCCCGTTGAAGAGGGCATCGTCATCACGCCACGGTAGCGAGAACCAAGACATGAGGAGCGGCAATTCGTTTTCAGGCCCTGAGTCGCCTCTCTGCGCTCGCGGGTGGAGTTGTTGCTGGCAGCGCCACCGGAGGCTGCGGCTCTGGGGCGAGAGGGCAGCCGCCCTCTCACGCTCTCCCGCAACACCGCGCCGCGGTCGTGAAGGGCGCCCTGGGTGGTCGTCAGGCCGCGGTTGAAACGCGTCGGTGGCGGAGCTTCAGACCGGGGTGGTCGTCGCTTCTTTGTGGCCGGGTGTGGGGGGTGGTTGGGGGGTGTGGGGTGGTGGCCGGGGTTGGGGGTGGTGTGGGTGGTGTCGGGTCGGGGCCGTGCCCGGGGTCGGGGGCGTGCCTGGGGTTGTGGTGTGTGGTTGTCGGTGTTGGTGTGGGGTTGCCGGTGTTGCGGGGTGGCCGCCCCGGGGCGGGTGCGGGGGTTGCGGTGTGGGACGACACGAGAGTGTCAGTGTTCAGCGACACGTGCGATGTCAGCGACGTTGGGCCCTGGCGTCTCGGACAGTGCTGCGGGTGTGGTCGGCCGCCCGGCTTTTGGAGCGAGGGTGAAGGAGCCGAAGGTGCCCTTCGCCGCGAAGAACAGGCCGCCGTCGCCGGCGGCGGCCAGCGCGTCCAGGCGCCGACCCGGCAGGGAACACCCCTCCACGGTCTTGCCGTCGGGCCCCAACTGCCGCATGCCGCCGTTGGCGTCCCCCACCAGGAGGCCGTCGGCGTACGGCAGCGGGTCGACCACCACCCGCCGATCCGCCTCGACCGACCACCGCGACGTCCCGTCGGCGGGATCCACCGCGAGGAACCCCCTGCCTGACCGCAGCATCCAGACCGACCCGTGGACGTACCCGACCGCCCCGAACGGATCATAGGATCCGAGCCGGGCGGGCTCGTCCGCACCGATCCCGAAGGTCAGCAGTGACGAGGCCTCGCAGACCGCCACCACCCGCTCCGTATCCAGCGGGACGAACGCCTTCGCGTCGGGTCCCGCGAGCGGGTCCGGCAACCGCCACCGCGCCAGGTCGCTCCCGTCGGCCGGATCGAGGAGAACCGCCTCATACCCGCTGCCGGTCAGCACCCCGCCAGCCCACGCGAGGGTCCGTACGGACGTCACCGGCGACGATGTCGTCCACCGGACGCTTCCGTCGGCGAGGTCCAGGCCACTCATCGGGGTGTAGCCGCGCCAACCGCCTATCACCACGGTGTCCGAGTGGACCGCGAGATTCCCAGTCCACCTCGGCGTCGGGGCACTCCACAGCGACGCACCCGTCCGCAGATCGATGCAGGACAGCAGGTTCGGTGCTTGTGGCAACACCAACACGCAGTCCCCCGCTAGGACGATCCCGCGCGGCCAGGTACCGAGCGGGACGTCCCAGCGCACCGCGCCGTCGGCGCGCTCCAGGCAGACCAGCCGGGTGTGCCGCTCGTGCAGGACGACACAGTCCGGCCCCACGACGAAAACGGAAGCGCCGCCCCGCTGGTGCAGTTCGCGCTCCCAGAGCACTGTGGCGATCATCGGGCCATCCCACCACAGGCGGCCCGCCCCCGACGACGGTGCTGTCGTGCGCAGAGTGGATGTCAGTGACGCGCAGGGTTGTGTCAGTGGGACGGTCCTCAGCTATTGGAAGGGGTGTGTATGCCGGGTGCTTGACCCCTCGGTCCGTCAGGTTGGATGGCACCGTGGCGAGACGACCCAAGACGAAGACGAAGCGACCTTCCTTCGGCATACCGAGGGAGATCATCCTGCTGACTGGGCACGATGTGTGGCCCTACACGTTCATCGCTGATAACGCGGGTGGCGGATGTGGCAAGGTCCCGATGCCCGCCAGCGCGGCCCTTGAGGACGTACAGACGGCGATCTTCACGCAACTTGCGGACCACACCCGCATACTCCACGGCGTTGAGATCGACGTCGAATGGTCCTCCCTGACGCCGGATTCGTGGGTGGGCCACATCCGGTGTGTCACCACGGAGGAGCCTGCTCCGCCTGGCGCGGCACCTGAAGTCGGCTGACCACGCGGTCACGCCCTGGCCGCTTACCGCACGGGACGCGAACCCGGACAGCGCCATCGGTAGTGCCCGCACTGTTGGGGCTCCCTGGGGACTTCCCACCGTGCTTCCCGCAGCCGGGACCTGGTCGCCCTGATTTCCCAACTCGTCGCGGCGCGGCGCGGGAACATACCCAAGCCCTGTGTGCGGTCGACGATCGAGGAGAGGTCAGGCACATGGGTCGCACGGATTTCCAGCTTCAGGTGCATCGGGGCCGTCGGCGTAGCCCGTACGGACTCGTCCTGCCGAGGGTCTATCGCCGAGGGTTGGGTGACGGTGGTGGTGTTCGCAGGAATGCCTGGATCTCGGCGGTTTCGGGCATGTAGCCGTCCGATGTGTCCACGACCAAGGTGGGGACGTCGAGGCTGATGGCTTTGAACTGCTCGGGGTCGTAGACGCCGGCTTCCATGTCGGCGAGCAGGGCCTGATCGCCGTGGGCCGCCCGGTGGCTGTCGGTGCGGGCGCGCTCGGTGATGCGTTCGGTGATGGTAGAGGTGGGCGTGACGCATCGGATGATGCGCAGGTCGGCGAGGTCCAGGAGGGGCTCCAGGCCTGGTCGCCAGAGCCGGTCCTGGAAGGCCGCCTCCGCGACGAGGGTGACCCCGGCCTGAAGGAGGACGGTGATGGCCTTGAAGAAGACGTCCAGGGTGGGGATGTTGAGGGGGTCGTCGCCGGCGGGCTGGTGATTTGGGGTGCTCATGACCATGCCCTGTTTGATCTCGTCGCGGATGATCGCCGGGCAGCCGAGCTGCTGGGCGAGGGCGCGGGCGAGCGTGGTCTTCCCTGTGGCGGGAGGGCCGCTGACTACGACGAGGGTCGGGCGGTTTTGCATGGGCGGCACTCCGATGCAGGCAATCATGACTGGTCAGGGCGGAGATCAGGGGCCGCCTGGCGGCTTGTGGAGCTGGAAGGCGATGAGCCCGGGCTGGTGGGCCAGTTTCTCGTACGCGGCTGGGTGGTGGAGGACCATCGAGTGAGCGGGTCGGTGTTCGACTAGGAGCTGTCCGGCCGATCATTGGTGTGTGCAGTCGGGGGAGGTTGTCTGCGCGGTCCCATAGCCTGCGCCCATGACCACCGAGGAGTACCTCTCGACGATTGACTCGCTGGCCGTGCAGCCGTTCCCGGAGGTGACCTATGTCGACGCCTCCGGGGGCGGTGGACCTGAGCATCACGTGCGCGAACTGCAGGTCAGTCGGGATTTCTGGGATGACGACGACGGGCGGGCCTGGGTTGAGGCAGAAGCTGAACTGCAGGCCCGCCTCGACGACCTGGCGGCACGCCTGACGGATCGGTGGGGCAGTGCGTTCGTCGCGGACCTCGGACCGTATCTCAGCGCCAGCTACGAGGGAGAGCCGGTGCCCGAGCCGCTCGACTACCTCAGCCAACAGGCCGTGAGCATGCAGGTGTGGCCGCTCCCCGACAACGGTCGTTGGCTTGCGCTGGCGCTCGGCCAGGCCGACAAGGAGCTGCCACTCATCCTGTTTGCCGCGGTCGGCCGGGCTTCCGCACTCGGCTTGAACACGAGTGGCCGGTCATGAGCGGAGCCACACGATGACAGCGGCAGCTGAGACAGTGCCGAGGAACACGTAGCCTCGCTGGTCATACCGCGTAGCGACCGCACGGAAGTTCTTGAGCCCCTTCACGGCCCGTTCGACGGTGTTGCGCTTCTTGTACCGTTCCTCGTCGAATTTCGGTGGCCGTCCGCCTCGTGATCCCTTGCGCGCTGTCCGGCTTCTTGCGGGGTCGGCCCGCCTCGGGCCGGGGGACCCGGATCTTCTCCAGCACTGGCGCGAACTGGGTACAGTCGGCCCGCTGCCCCGGTGTGACGATCAGGGACAGCGGGCGGCAGCGACCGTCCGCGCTCAGGTGGATCTTGCTTGTGAAGCCGCCGCGCGAACGCCCCAGGCCCTCGCCTCCCGCACCACCTCCGCCAGCCGGTCGACGAGGCTCTGCCACGGAGTTTCGTCCTGGTGTTCCCCCGTCTCGTCCCCCTTTGAGTCGGCGAGGGCCGGCGGGGGGTCGGTGCGGGCGCCGGCCGCGTGCTGGTGCGCGCGCACGATGGTGGAGTCCACCGAGATGTCCCAGTCGATCTCGCCCACCGCATCGGCCGCGGCCTGGAGCTGCTGCAGAAGACGTTCCCAGGTGCCGTCGGCCGACCAGAGCCGGTGGCGCTCGTAGACCGTTTTCCACGGCCCGAACCGCTCCGGCAGATCGCGCCAGTGCACCCCGGTCCGCACCCGGTGCAGGATCCCGTCGATCACTTGCCGGTGATCACGCCACCGCCCGCACCGACCGTTGCTCACGGGCAGGAACGGCCGCAGCCGTTCCCACTCCGCGTCCGACAGATCACCGCGTTCACCCCGCCCCATGCACGGGAGAACGATCCGACCAGGTGACAGTCACATGATCGGCCGGACAGCTCCTAGTAGTGCTTTGTTAGGTGGTGTCGTAGGGCTGCCATGGCACGGTTTGCTGGCAGGTGGGGCAGGTGCCGGTCCAGGTGGCGATGAGGTGTTGGAGGAGGTCCAGGGCCTGGGTAGAGGGTCAGGCCCTGGCAGGGACTTTTGGGTTCCTCCGCTGTTCGGTCAGGAACAGGTGGGCGGCGGTGACGAGGGTGACGTGCCGGTGCCGGCCGGTGAACGAGCGGCCCTCGAAATGGTCCAGCCCCAGAGCGGTCTTCAGCTCGCGGTAGTCGTGCTCGATCCGCCAGCGGGCTTTCGCGAGCCGGACGAGGTCCTTGGCGGGAATGTTCGCGGGCAGGTTCGAGATCCAGTACTTCACCGGCTCGGCCTCGCTCTCGGGCCACTGCGCGACCAGCCAGACCAGCGGGATCGTGCCGTTGGCGGCGGGTTTGGGCCGGCGGCCCGCGAGGCGGATCCGCAGGCGGACGAAGTGCGAGCTCATCGCGGCCCCGGAACCCTTGCGCCAGGTCACGGGCCGGCCCCGGTGACGTCCGGCGGCCAGCACGTGGTCGCGTAAGGAGACCGGCCGGGTGCGATACCGGGGTTTGGGACGGGGCCCCAGGCCTGAGTAAGACGTCATCTCATTTGGCCAGTCGGCGGTAGCAGATGAGGGTGCAGGCGAGGCTGGTGAAGGCGAGGAAGTGTTCGGCCTTGCGTTCGTAGCGACGGTGGAGGCGTCGGCAGCCGGCGAGCCAGGACATGGTCCTTTCGACGACCCATCGGTGGCGGCCGAGTCGTTGTGAGGACTCGATGCCTCTGCGGGCGATGCGGTGCGTGATGCCGCGCCCGCGTAACCATCGGCGCAGGTGGGCGTAGTCGTAGCCCTTGTCCGCGTGAAGCTTGCCGGGCTTCGTCGTCGGCGTCCGCGTCGTGAGCGGATGGGCGGTATGCCGCGGACGAGGGGCTCGAGGGCCTGGCTGTCGTGCAGGTTCGCGCCCGAGATTCCGACGGACAGGGGCAGACCGGTCCGCTCGGTGATCAAGTGGATCTTCGAGCCGTACTTGCCCCGATCGACAGGATTCGGACCTGTCAGATCCCCCTTTTCAGGGCCCTCATGTTCACCGAGTCGATCGCGCAGCGGGACCAGTCGAGCTCGCCGCGGGAACCGAGTTCGTCGAGGACCAGGCGGTGGAGCTTGGCCCACACGCGGGCCTTGCTCCATTCGGAGAAGCGTCGGTGGGCTGTCGCCCCCGAGGGGCCGAACGATGCCGTGGGCAGCTGCTGCCAGGTACAACCCGACGTCGCGACGAACACGATCGCGGCCAGTACCTCACGGTCGCCGTGCCGACGCCGTCCACCACCTTGGGGCCGCGACGGCGCCTCCGGCACCACCCGCTGGAACAGCACCCACAACTCGTCCGGCACCAGACGCTCAACGATCCCCACCATGACCGACAGCCTACCCACGAAGCCCAAATGAGATGGCTTCTAAGCGGGCTGATGCGGCTCGGCGTCTTCTGTGTGAGCGGTCATCTCGCCTTCGACCTGCAGGACGTAGGCCAGCCCGCGGTCTTCCAGGCCGTGGCGGAAGTCGGCGTTCGCGCCGTAACCGGCATCCGCGACCAGTGCGGCAGGCCGCAGGCCGATACCGGACAGCTCATCGAGCATCTCCAGCGCGAGCTGCCACTTCGGGCGGTGATGTTCGCTGGCGGGGATCCGGCAGGCCGCCCGGCGATCGGCGGCCTGCGGCCCGTCCCAGGAGGCGGGCAGGAACAGCCGCCAGGACAGCGGGCACGAAGCCGTGTCCGAGGCGGCGTGGACGCTGACGCCGATCTGGCAGTTGCCGACCTTGCCCAGCGTGCCCGAGTACTGCCGGGCCACCCCAGGCGAGGCCTTGCCGTCCTTGGGGAAACCGGTGTCGTCCACCACCCACACCTGCGGACGCACCACCCGCACGGCCCGCCACGCCAGCCCGGCCCGCACGTCCTCGACCGGCCAGGTCGAGGACGTCATGAACTGCTGCAACCGCTGATGATCCACCCCAAGACGCTCGGCCATCGGCTGCATCGACTTGCGCCGGCCATCCAGCAACAGACCGCGCAAATACAGCTGGCCCTTCTCCAGCCAGTCCCGCCGCACCAACGGCGCGAACACCTCGGAAGCGAACTCCTCCAACCCGACCCGAACCGCGCCAAGCTCCCCAGCCCTCATACAACCAGCGAACTACCAGACACCCGACGTGACAAGACCGGCTAACAAAGCACTACTAGAGGCCGTTGCGTACGGGCGATCTGGCATCCTGCGGATCATGACCTATTGGGATCCGATACCGTCTGCCCGCGTCCTGGTGGGCACGCCCCATCCGCTGTGGCAGGACGGCCTTGTGCGGCACGACTGGTCCGGGCCCGCGCCCGATGGCTGGGAAAACAGGGACTGGCGGAACGTCCCGGGTCCCTTCTACACGGCCGGCACCGACAACTGCTTCACCGGCAGGCAGTGCGCGCCGGAGCATGTCGCATACGAGGACGAGTACTGCACCGAGTTCGTCTACCGTCAGCCGGTCGAGGTCGCCGGCGTCCACGAGTTGACCTGCGCCGGGGAGTGCGACCCCTTCGGGGCGTACGGAGGGGACGGCGACCGTCACTGGACCCCAGAGCTGGTCCAGGACTGGTGGAGTGAGCGCCGCAGAGCGCGGGAATGGGCCGTAAGGGTGGGGTGGGGCGAGTGGGCGACCTCCGAGCGCGAGCAGTTCCGGGACGCCGCCGCGGGGGCACGGGCGTACCTCGCCCACCTGGACCACGGCCTTGGGGAGTATCTTCGCGACTACATGTTCTGGCTGTCCGAAGGCCGCCCAGCCACCCCTGGTGAGCGCCTGCCGGAACTCGACGCGTAGGTGCGGAAGCGCAGGTCGCACCGAGCTAGGAAACCCGGCCCGTCTCAAGCGCCGGGCCGGTAGCCGTCACGCCCAGGGCGGCCCTGAAGTGTCGGATCTATCCCACGCTGGACTCCACTGCCGACGTGGTCCGGGTCCATGTAGCGTCAGGGCCAGGGGAATGAGATGAACTTCGACGAGAACGAACCGCAGTCTGTCCGAGAGGAACGCTTCACCGCCGAACGGGCCGAACGCAGAGAGGCGCGCAAGGCTGCGTCGCTCGACTCGCGAGGAGCCCACCTCGGCGCGGTCATCGTGACCGTCGCCCTGGTCCTCCTCAGCTGGTACGGCGAGCTGATCGCTCTGGGCATCGTCAGCGGCGTCTTTGTGCTCTGGTTCGCCGCAGCCCTTGCGTGGGCCTACGTCGACGGTGACCATGGCCGGCACGCACTCCAGCGTGCGTACAACGTCACCTTCGGATGGGGCGACGGGTTCTGAGTACCAAGTACTCGGCACCTGGCTCCCGATCCGGGCATGGCAGAAGTGCTGGAGTGGAGTTGGCGGTCGCGGGTGTGACCGCGGTCAGTCGCGTGTGTGTTCGCGGGAGGGCGGCCGGCTGGCCCGGCGGGACTGCCGGCGGGTGATTCGCCTGGTCATGAGGGTGATCGCGGCCCAGGTGATCAGCGATTCTGAGTGTTAAATGAGGCGTTCATAGTCGCGGGCGTGTCTGCGGGCGTGCATGACCCAGGCGATCGACCTCTCGACCACCCAGCGGCGGGGCAGGACGACGAACCCGACCGCGTTCTTCGGCCGGCTGACGGTCTTCAACGTCAGGTTCAGGTACTTCTTCGCCCAGTCGACGAGCTGTCCGGCGTAGGCGGAATCGGCCCAGACGATCGTGATCTCGGGGTGCATGAGCCTCAGCCTGAACAGGACTTCCTTGGCCGCGTCGCGGTCGGTCATGTCGGCCGGGGTGACCATGACGAACAGCGGCAGGCCCTTGGTATCCACCACAAGGTGCCGCTTCCTGCCGTTGATCTTCTTCGCTGCGTCGTAGCCGCGTGAGTCCTTGCCGACGGTCTCGGCGGCCTTGACGGACTGGGAATCGATGATGGTGGCGACCGCTCCAGGGGAGCGTCCCATGTCCCGGCGGACGCGTTTGCGGAGCTGATCGCGGATCTGCCCGATCACCCCGGCGGCGGCCCAGCGGGCCATGGCGTTGTAGCAGGTTCGCCAGGGCGGATAGTCCTTGGGCAGGGCCCGCCACTTGCAGCCGGTGTCGACGACGTACCGAATTGCGTCCACGATCTCGCGCCGCGGGTGCTTCTCCGGCCGCCCGCCACGAGGGGTCTCGCAGGCCGGGGTCGGTAGGAGCGGTTCGATCAATGCCCACTCGTCGTCATAGGTGTCCGAGGGGTAGCAGCGATGCCGGGCCAACGTCCCCTCCCTCCAACGAGGGTGAGGGCCGGCCGCTTCGCGGCCGGCCCTCACCAGGATCATGCGTCGATGTAGTCGGCGATCACATCGAGGGTGGACTCGACGGAGTTCAGCTGGGTGTTCAGGTGCCGGATCCACCGGCCCTTGGGCTGCAGGACTGTGTGCGGGCGACGACGCCGGTGATGAACCGGCGGATCTCGGTGAGCCTCTCGCGGATGACCGCGACCTCATAGGCCTGGAGCTCGCTGGGGTCGGAGCAGAACTTGTAGCCGCCGCCTTCGTCCAGATCAGGGGCGGCCATTCCCGTTCGGCGATGGTGTCGCGCAGGCAGGCCAGGCCCGCACGAGCTTGATGGGGTGAGAGTTCGCTGGACCTGACCAACTGCTTGAAGGCCAGACCGGCAGGCCGCGCCTCGAAGAGCACGAACCGGAGGGTGTCGGCGTGCCGCTGGGCCGCGGGGGACCGGCGCTGTGACGCGCGCGGCATCCCACTACTCGCCCTGCAGCAGACGGGCCAGTTCGCCGTCGACGTCGACCTTCCCTGTGTCCACGGCAGTCTCGATCCAGTCGAGCGTCGCCCGCACGCGCGCAGTTCTCCCGGGTGGAGACCATGTATCGACAGCTCTCCAGATGGGCCGAGACCGGCCTCATCCACAAACTCGGCCCCGGCCTCTACGCCGCCACAGCATGGACCCCAACTCCCCTTGCGTGACCAGCGAAAGCGCTAAATACCCGGCCTTGGGCCCTGACCCGGATTTTGGACACCGGAGAGACTTGGATCTTGATGGTCCAGGAGAACGGAGTCCCTGTGGGGATGAAGCACTATCCCGCCGAGTTCAAGGCGGACGCGGTCGCGTTGTACCAGTCGCGGCCGGGAGCGACGATCAAGTCCGTCGCCGCTGACCTCGGGGTGAACACCGAGACGCTGCGGAATTGGATCCGGGCCGCTGACGGGCGCCGTTCCGGTGCCCACTCTACGCCCCCGGCCGCTGCGCAGTCCGGTGGTGACGCCGTCCAGGCGGAGTTGGCTGCCGCCCGGAAGAGGATTCGTGAGCTGGAGGAGGAACGCGACATCCTCCGCAAGGCGGCCCGGTATTTCGCAGGGGAGACGCGCTGGTGAACCGCTGCCAGTTCGTTGACGATCACCAGCGCCGGTTCGGTGTGAAGCGGCTCTGCGACCTCCTCAGGATCGCCCGCTCGAGCTTCTACTACTGGCGCCGCACCGCGGCCGCGCGGACGGCCCGGCAGGCCGCCGAGGCCGGGCTCGCGGCCCGGATACGCAAGGTCCACGAGGAATCCGACGGCACCTACGGCGCCCCCAGGATCACGGCCGAGCTCCGCGACGAGGGCGAACGGATCAACCACAAGCGGGTCGCGAGGATCATGCGGACCATCGGGATCGAGGGGGTCCGTCTGCGTCGTCGGCACCGGACCACCGTCGCGGACCCGGCCGCGACGAAAGCGCCGGACCTGGTCGGCCGTGACTTCACCGCGGCCGAGGTGAACACTCTTCGTGGTGGTCTTCTTGGCCGGTGCCTTCTTCGCGGCCTTCTTCTTCGGCGCCGGCATCTCGTGCACGGTCGCCTCAGCCCCGGCCTTGTCGTCGGTCTCGCCGCGCAGCTCGCGGGCGTGGGCGACGGACTTCTCCAGCGCGGCCATCAGGTCCACGACCGGGGCCGTCGCCGCCTCCTCATCGTGGGCCGGGGCAGCCGGTGCTCGGCCTTCGCCGCGATGACCTCTTAGTGCCCGGGCTGGAACCTCCAATCAGTCGGACCCCATAGTCGAATCCGAGCCAATTCACCCCCTGCCCAAAATCGATCAGGCATGCGAAGAAGCGGTCCGCCTATGCCTTGCCTGAGCAAGAGGTGTGAGCGTACCCACGGCGGGGGGCTCGACCCTACTCGCTGGTTCAACTGACGCAAAAGACACCATAGTTGTTCAACGCCATTTAATATGACGGCCTGTGCCAGTGGCACAGGTGCCTCATCAGCATCCGCGCTTGCCGCACGCCACGCCTCTGTCCGCTCTGGACGGGGAGATACGGAGCAGCTCCTCCCGTGTATCTCGACAGCTACTCCGCGCGCGGTTTCCGCTCCCTAGCCCAGGTGACGGACATCCCGGTCAGCGGGCCCACCGTCCTGGCCGGCCGCAACGACGGCGGCAAGAGCGCGGTGCTGACCGCGCTGGCTTTTCTCCTCGGCACCCACCGCCTGACCGACGAAGACCGCACCTATGTGCAGGACGAGGAGGGCTCCAAGGGGCGGCGGTGCGCCGAAACCTGGGTGGAGGGCCAGTTCCGGCTGGACGCCGAGGAACAGGCCCACAGCGGGCTTGGCGAATGTGTGCGTATCCGTCGGCGCTCGCTGCTGGGGGAGGCGACCTGCCTGGAGTATTTCGGCAGCCAGCCCGCCGACCCGCAGTTGCGTGACCTGGGCCGACTGCTCAAACCGGCGCTGACGGCGCTTGTTGCCGAATACGGGCTGTCCCCGGCAGGAAACCTCAAGGAGGATCTGCTGGCAGAGCTGAGGGCACACGCCAGGACGCTGCCCCAGGACGAAGGGTGGCAACCGCTCCCCAAGACACTCGAGGAACGACTCCCGCAGCTTTTGTCGTTCGGTGGGAAGGACGAGAGCCCCGACGACGCCGTGCGCACCGCTTTGAGTAGCAGCTACAAGACGCACCTGGAGGACGAGACTCTTCAGGGCCGCGTCCGGGAGATCGAGGGAGAGATCACCCAGCGGCTGGAGAAGGAAGCCGACTCCCTGTGCCTCCACATCCGCCAGCACTGCGCCGAATACGTCAGCGTAAACGTGAAACCCCTGGTCTCCTTCAAGGGAGGCTTCCAGGGCGCCCCGCTGCACGTCTCAAGAGCGGACGGCGAACCTGTCGACCTGACGCGCGCCGGGCAGGGCAGCACACGCCGTATCGCCCTGGCGGTATGGGAGTGGACCAGCAACCTCCTGGAGAACGCCGAACTGGCCGCCTCGGCAGAACAGGGAAACACCCAACCTACGCAGACCATCGTGGTCTACGACGAGCCCGACACCCACCTTGACTACCGCCACCAGCGCACGGTCATGGACATCATCCGCAAGCAGTGCGCCCTGCCCCACGTCAGCGTCATGGTCGCCACCCACTCGATGAACCTCATCGACGGCGTCGACATCGCCGATGTCGTCCACCTGAGCCTTGGACCTGGCGGGCGCACCGTCGTCGAACGGCTCGATGACGATCAGCACGACGGGATTGATTTCCACCTGGGCCAGATCGCGGCATCGCTGGGTCTGCGCAACTCCGTCCTGCTCCACGAGCGCTGCTTCCTGGCCGTCGAGGGCGACACAGAACAAAAGAGCCTGCCGCTGCTATTCCGCCTGGCCCAGAACATGTCCCTCCAGGCAGCAGGTATCGCCCTGTGGGGTTGCGAGAACAACGAGGGAGCCCTGCACCTGGCCCGCTACCTCGTCAAACATCAACGCACAGTGATGCTGATGGTGGACGCAGACAGCCGCACCAACAAACTCTTCAAAGACGAACGCCTCCGGCGCGCCGGTCTCGACCTCGAAAAGCACGTCTCCTACGTCGGAGAAGCCGACGGCTACAACGAGCTGGAAGAACTCTTCAGCGACGAGCAGTGGGCCACTGCCGCCAACACCCACTGGCCTCGCCCGGCCCCGCAGACCTGGCAAGCCCACGACTTCACGGCTCACCGCGACGGCAAGAAATTCAGCGCCCGTATCCTCGACATGATCCAAAACCAAGCCGGAAACAACAGCCCCAACGGCAAACCCGCCATGGTCTACGGGCTGGCCAGCACCCTCACCACGGCCCAGGACGTGCCCCGGCAGCTACGGGACATCTTCACCCACCTGCAAGAACTCGCTCACTGATCCGGCGCCGACCGCCGTGCACGACGCGCCCGCATACGCTCTTTGCGCTGCTCGTCCGTCGGCGTCTGCCACACATGCCAGCCAACCGATTCCACCCATTGGCGAGCATGGATCCGAGCATCGATCCCACACCACCTGCACCCCCCCGGCGAGGGAACGCAGGCAGCACGAGCAGACCTTGGAGAGGGCATCTCTCCTCCTTCCCACGCTCTCCATCTTCCCTGCGAGCACTGACAATCACGCTGAGCGACAAAGCCGAGGTGTAAGCGCATGAGGTTTCTCCACACATCCGACTGGCACCTGGGCCGCCGGTTCCACACAGAAGACCTGATCCCCGCCCAGCGTGCCTTCCTCGACCACCTGGTCGACACTGCCCGAACCGAGGATGTCGACGCGATCCTTGTCGCAGGAGACATCTACGACCGGGCCATCCCCAGCCTGGACGCCGTGCGCCTGTTCAACCGCGCTCTGCACCAGCTCGCCGACCTCGGCGTGCCGATCATCATGATCAGCGGAAACCATGACTCCGCGCACCGCCTCGGCGTCGGATCCGGGCTCCTCGCCCGTGCCGGGATCCACTTGAGGACTGACCCGGACACCTGCGACATCCCGGTCCTCTTCGACGACGCCGACGGCCCCGTCGCCATGTACGGCATCCCCTACCTCGAGCCGTCGATGGTCCGCGACCGCCTGGAAGCCGAAGCCGTCTCCCACCGCGCAGTACTGACCGCAGCCCTGGACCGCATCCACGCCGACCTCACCAACCACCAGCCGGCCGGTACCCGGTCAGTGGTCCTTGCGCACGCCTTCGTCACCTCCGGCACCGGACAGCCCGAGGAACGCGATGAGAGCCAAGAGTCCACCAGCGAACGCGAAATCGCCGTGGGCGGTGTCGCACACGTAGGCTCCGACGTCTTCGACGGGATCGACTACGTGGCCCTGGGCCACCTCCACGGCCCCCAGCGTGTCACCGACCGCATCCACTACAGCGGCTCCCCGCTGGCCTACTCCTTCTCCGAAGCCCGCCACACCAAGTCGATCACCCTTGTCGACCTCACCCCCAATGCCGTTCCCGCCCTCACCCGCCAGCCCTGCCCTGTGCCTCTCCGCCTGGAACGTGTGTCCGGCTTCATGGAAGACCTCCTGACCAATCCCGACCACGAGCCGCTGAAGGATGCCTGGCTCGAGGTCACCCTCACCGACACGGCCCTGCCCTTCGAGGCCATGGCCCGCCTGCGCCGCCGCTTCCCCCACACCGCCAGCCTCAGGCACAAGCCCGCCTTTATACCCTCCCAGGCCACGAACACCCCCACTTACAGTCAGCGCATCCGGGGCCGCGGCGACCTCGACATCGCCAGCGATTTCATCAGCAGCATGCGCGGAACCGACCCCACACCGGACGAACACGCTCTGCTACAGCAGGCGGTCGAAGCCTCCCGCCTGAACGAGCAGCAGAAGGAATCCGTCTGACATGCGCTTGCACACCCTGCGCCTGCAGGCATTCGGACCCTTCGCCAGCACCCACACCATCGACTTCGACGCACTATCCGCCGACGGCCTGTTCCTCCTGCACGGCGACACCGGAGCGGGCAAGAGCACCATCTTCGCGGCCATCTGTTTCGCTCTCTACGGCAAACCACCGGGCGACCGCGACCTGCTGCTGCGCAGCCACCACGCTCCCGCTGGCCTCCTGACCGAAGTCACCCTCGAAGTCACTCTTGCAGGGCGCCGCCTGCGCATCGACCGGATCCCCGCCCAGATGCGCCCCAAGCGATCCGGTGAAGGCGAGACCTCCCAGAAAGCAGAAACCCGGCTCAGTGAATGGGCCGTCGACGCCGACGGGCAGGGCCGCTGGGAACCTTCCAGTAAGTCCCACCAAGAAGCAGCCGTCGAGGTCACTGACCTGCTGGGCATGAGCCGGGAGCAGTTCTGCCAGGTCGTCCTGCTGCCGCAGAACGAATTCACCAAGTTCCTCCACGCAGACGCCCACGGCCGACGAGAACTCCTCGGCAAACTCTTCCGCACCGGTCGCTTCTCCTTCATCGAGCGCTGGCTGAACGACCACAGCCGCACCACCGAGAAGAACCGCGACGCCACCCGCGCCGACGTGCTGCGCCTAGCCGAACGTATCCACCAGGCAGCCGGACCCGACCTGGAAACCGAGTACACGGCGCCCACCCCCGACGACCCGAACACGCTCACCGAGCCCGCCCGCGCCTGGGCCCAGGATCTCCTCCGCGTCAGCCACACCGACCACGCCAGGACACTCCAAGCAGCCACAACGGCCAAGGAGAACCTGGCCAGACAGCAGACCTTCGAAGCCGCGGCCCGCGAACTCCACCAGCAGCAAACCACCTACACCAGCGCACGGCAGCAACTCGACCTGCTCCAGGAACAGACACCGCACCAGGACACACTCATCCAGCGCCGCGACCAAGCCCGCCGCGCCCAACAGGCAGCACCACTGCTGCACGCCGCGGACACCGCCGCACACGACCACACCCGTGCCCAGAGCGTTGAACGCAGCGCCCGCGAGCGCCTGTTGCCCGAACACAAGGACCTTGACGCCAGCCGGCTGGAAACCGCCGAGCATCGTCTTCGCGCCGAAGCTGCCATCCTGACCACCCTCATCCCCGAAGAAGACACCGTCCGCCGGCTGACCACCGAGCTGGAGCGCACCGACGCCGAACGGCAGGACTTCGCCACCCAGCAACGCACAGCCCAGGACTGGCTCGAAGCCGAGCCCGCCCGGCGCGGCGCCCTCGAAGCCCGGCGAGAAGCCGCCCGCCAGGCCGAAGAAGAAAGCCGCCGCCACCAGACCGCCCTGGACGGCCTCAAAACCCGCCTCGAAGCAGCCAGGCGCCGCGACACGCATCTCGCCAAGGTCACCAAGGCCGAACAGCAGCTGGCCGATGCAGAAGCGGTCACCGGCCAGACCGGCCAGGACTACCTGACCATCCGCCGCCGGCGCACCGAAGGCATGGCCGCCGAACTTGCCGCCACCCTCACCGACGGCACGCCCTGCCCGGTCTGCGGATCCTGTACCCACCCGGCGCCCGCCGCTGCCCAGGACGGGCAGCCCACACGCCAGGACGAGCAGGACGCGGAAGCCCTCCACGAGCAGGCCAAGACCACCCAGAAAGCCGCCGCGGCCGTGCTGCACGGGCTCCGCGAACAGGCGGCCACCGCCGCCGGTGAAGCCGGCGACACCCCCCTGACCGACCTCCAGACCCAGCACACCACGCTCACCACGGAGTTGACCGACGTCCTGGACCGCGCTGCAGACCAGGGCACCGTCCAAGAAGAACTCCTCGCACTCGACGGCGAGCACACGGCCCAGACCCAGCAACACAGCACCGCCACGGCCGGCCTGTCCGCCCGCAACGCCCACTACGACACCCTCACCCAGCAGCTCACCGAGCTGACGGCCAAGCTCACCGCGGCCCGCGGCACCTATCCCACTGTCGCCGCCCACGCCGACGACCTCACCCGCACCGCCCACCGCCTCAAAGAGACCGCCGAGGCCTCCCGCAGCCTCGCCGCCGCCGTCCAGACCCTCGCGCACCGCACCGACCAGGCCACCCTCGCCGCCAAGGACCAGGGCTTCGACACCCTGGCACTCGCCCAGCAGGCCCTGCTCAACGACGAAGACCTGCGCGCCATAGAAGAAGAGATCACTCAGTGGCGCGAGGCATGTGCCGCGCACACCGCAGTCCTGGACAACCCGGCACTGCAGCAGGCCGCCGCACAGCCTTCCGCCAACCTCGACGCCGCCACGGCTGCAAGGGCCACCGCGGATGACCAGCACGCCGAGGCCGCCGCCGCCGCCAGTGCCGCCCACACCCGCAGCCAGGCCCTCACCGCCCTTGCCGCCAACCTCGGCACCGCCATCCAGCGCCTGCAACCGCTCGAGCAGGCGCACCTCACCGCCCGCCACCTGGCCGAACTCGTCACCGGCAACTCACCCAGCGCCCGGGTGCGCATGCAGCTGGAGGCCTACGTCCTGGCAGCCCGCCTCGAAGAAGTCGTCACCGCCGCCAACACCCGCCTGCACATCATGTCCGAAGGCCGCTACAACCTCTCCCACTCCGATCACCAAGCCGCCCGCGGCGCCCGCTCCGGCCTCGGACTGGAGATCACCGACTCCTGGACCGGCCGTCCCCGCAAGACCGACACACTCTCCGGCGGCGAATCCTTCTTCGCCTCCCTGTCCCTCGCCCTTGGCCTGGCCGACGTCGTCACCCACGAAGCCGGCGGCAACCCCCTGGACACTCTCTTCATCGATGAAGGCTTCGGCACTCTCGACGAAGACACCCTCCACAAGGTCCTCGATGTCCTGGACTCCCTGCGTGCCCACGACCGCACCGTCGGCGTCATCAGCCACGTCCCCGAACTGCGCCGCCGCATCACTCACCGCCTGCACGTCCGTAAAAGCCCCGCTGGATCCACCCTCGCCCACCTGACCGAAGCAGCCGAATAACCTGCACCCTGACAGGGCGGGGCGCCTTGTCCGCCCCCGTCCAGCCGAACTCCACGGAGCAGCACACCTTCATGGCTTCCGATATCGAGCTGCGGCCCCACCAGAAGGAAGCCGTCGCCGCCGCGACCGCCACGTTCCGCGATTACGCCCGCGCGAGCGTGATCGCGGCCTGCGGCACCGGCAAGACCCTCATTGCCGCCCGTACCACCGCCCGTATTGCCCCCCCGTGGCCGTGTGCTGGTGCTGCTGCCGACAGTGGACCTGCTGTCGCAGACGATCCGTTCCTGGCGTCTGGCCGGCCGCAAGGGCACCACTGTGGCGGTGTGCTCGGCCCGCCAGGCCCTCGACCACGAACCGGTCGGCACCGACATCCCGCTGACCACCGACCCCGCCGAACTGACCGCCCTCACCGCCGGCGACGCGACTGTCGGCGTACTCGTGAGAGTGCTCAACCCAGTACGGAGATCTGTGCACCAATCCTTGCCGCCGAAGCCGCTTCAGGGAGCGAGTAAGGTCCCGTCGAAAGGGGGCGTCATGGAATCACTCGGAAACCTGTTCATGGCCGCGGTTTGGGGCATTCCTCTGGTCACCCTGCTGGGTGGGGCGGTCGCCGTTGCGGCTGTCACACGTTGGCGCCGCCGTGAAATCAGAGCTTTGAAGAGGGCTGAGGAAGAGCAAGGCGGACCGGCCCTCGAGGTGTCCGGCCGATAGGGAGGCTGCCTTCAGGCTGCGTCGTTGCGGTCTCGTTCGATGGCGGCCAGCCGGTTCTTGAGGCGGTAGCTGTTGCCGTTGATGGAGACGACCTCGCAGTGGTGCAGGAGCCGGTCGAGGATTGCAGTGGCGAGGACTTCGTCGCCGAAGACCTGGCCCCATTCGCCGAAGGTCTTGTTCGAGGTGAGGATGATCGAGCCCTTCTCGTAGCGCTTGGAGATGACCTGGAAGACCAGGTTGGCCTCGGTTCGCTCGAGTGGCTGGTAGCCGACTTCGTCGACCACGAGGACCGCGGGGCGGAGGTAGCTGGTGAGCTTGCTCATCAGCCGGCCCTGGTCCTCGGCGGCCTTGAGGTGGCGGACCATGTCGTCGAGGCTGGTGAAGTAGATCGAGTAGCCCGCTCGGCATGCCGCGACCGCGAGTGCGACGGCGATGTGGGTCTTGCCGACACCGGGTGGCCCGAGCAGGGCGACGTTGGCCTTGTCCTCAACGAAGGACAAGGTGGCCAGGTCCTTGACCTTGCGCGGGTCGAGTTCGGGCTGGAACGAGAAGTCGTAGTCCTCGATGGTCTTGTGGTGCGGGAGCTTCGACAGCCGCAGGCCGTTGCGGAAGCGGCGGTCGTCACGGACCGCAAGTTCCTCGGAGAGGACCAGGTCAAGCAGGTCGAGGTAGCCCATCTTCGCCTCGTCGGCCCGCTGGATGTAATGGCTCAGGGCTTCGGCCAGGTGCGGCAGCCCGAGGCGGGTGGCGGTGGTGCGGATGCGGGTGCTGGTCAGCTCGCTCAACGGGCGTCCTTGGTCGGGGCGGGCGGATTGAAAGGCCGGGTGCCGGTCAGCTCGTCATAGACCGACAGCGGGCGGCGGCCGACCTCGACGTGAGCGGCGGCAGACCTGCTGAGAAGAGCCTGCAGCGGTCCGGTCTGCGAACCTGTCGGCCGGCCGCGGCGGGGAGAAGGCAGAGCGTCGCCAGTGGTGACACGGCGGCCGGCGCCGGTGGGCAGACCGTCCCAGTGCGTCTCGTCGACGACGTGGGCTCCGCGGCCGACTGCCCGCGCATGAACGGCCAGCAGCGTCAGCCCGCCAGCATCGGGGACGGTGGAATGCAGACTGACCTGCGATTTCGTCGCCCGGACCTCGACCAGCTGGCGAGGGCGGACCTTGCGGGCGGGCACCGAGTAGAGGTTCGCATCGAAAGCAACCAGACAGTCCTTGCCGACGTGCCGCAGATGCCGCTGGGCAACCACATACGGAGTTCCCGGCAGTGGCCGCAGGGCTGTGTGATCGCGAGCGGCCCGATGGCCGATGACCTCGCCGTGGGTGGAATGGACCTTCGCCCGCCGCAACGGCACCCAAGCCGCGAAGGCGGCGTTCATCTCCTCGAGCGAGGAGAAGGCCCGGCCCGCCAGGACATGATCGCGGACGATGTTCACCTGGCGCTCGACCCTGCCCTTGCCCTGCGGCCGGTAGGCCGCCAGCACGTCGATGTCGTAGTCGTAGTGGCCGGCGAACGCGACCGCCTCCGGATGCAGCGGAACGGCCTCACCCGGGGCGACGTGCCGGCGCACGACCGTCTTCGTGCGGTCGTAGACGATGCTCATCGGCACCCCCGCGAAGTGCGCGAAGGCCTGGCGGTGGCAGTCGAAGAACGTCGCGAGATCCTGGCTGGTGGTGAAGCAGCAGAAAGGATCACGCGAGTACGACAGCGTCATATGGAACGAGTAGACCTTCGGGATCCCGACATGAGCGAGGACCCTGCCCTCATCACCCCAGTCGACCTGGGCCTGAGCACCGGGAACCACCTCGAAACGCCGGTGCAGACCCGCCAGCTCGCCCGGGCTGATACCCAACTCCTCCGCGATCCGCGGCCGGGCCTCCTGCAGATAGATCTTCACCCGCTGGTAGTTGATCGCGACCCCGTAATCCGCGACCAGGCGCTCGTGGATCACCGACCCCTTCAGGAGCACCTCGGACCTGAGCATCGCGTCGATGAGAGGCGCGATCTCGTCCACGACCCGCCGCGGCTGACGGCCATCGGACTCCCGCCTGGGCAGCCCCGCCGACGCCGGATTCTTCAGATACTTGCTGACCGTCCGCCGGTTCAGCCCGGTCTCCTTCGCGATCTCCCGCAGGCTCATCGCACCAGACGCATACAGCGGGCGGAACCGCCTCAACTCCAGCCAGCGATGTGGGTCCAAGACCACTGCCAGACGCCTCCTTGCCGTCCCGAACGGACGACAACAGCCTCACGCCAGCACCCCGTCACCGCCCCGAAAACGGAGCACCTTCCCTCGTACGAGGTGGCGCACGTCCACCTGTACGCCGACAAAGGGGCTCCAAGACCGGACGAAGCCCTGTCGACCGGGGTAGAACGGGCAGCAAGCACCACTTGATCACCGATGCCACCGGCATCCCGCTCGCTGTCACCTTGACTGGGGGCAACCGCAATGACGTGACCCAGCTCGTTCCGCTACTCGAAGCCGTTCCGTCGGTGCGGGGCAAACGCGGCCGGCCCCGGCGTCGCCCGGACGTCGGGCTCGGTGACCGCGGGTACGACCACGACAAGTACCGCCGTCTCGTGTGGGAGCTTGGGGTGAAACCGGTGATCGCCCGCCGCGGGACCGAGCACGGTTCCGGGCTCGGCACCCGCCGCTGGGTCGTGGAGCGCGCATTCGCCCATCTGCACTGGTTCCGCCGCCTGCAATCCGGTGGGAGATCCGCGATGACATCCATGAAGCCTTTTTCAAGCTCGCCTGCTGCATCATCTGCTGGCGGCGCCTGACGAAGCTCGTGCCTCAGTCGCTGCGGTCTGAGCTGAAGCCGCGGTCCTGAATCACCGGAAACGTCTTCTCCGCATCAGCAAGCCACGCATCGATCTCGTCGTGGGAGGACCGGATGGCGCTGATCAGCTCCATGAGGGCGTCCAGCTTCTGCCTGCCGACGTTCAGGCGCAGCTCCTCAAGCGAAACTTCCTGGTACGGCATGCTCAGCTGCCACCAGAAGCGCATCAAGTAGCGACACTCCTGCGGCTCCCGGTCATCCGCGAGTCGACTGTGAACGACTGCTTGGACGCACTGCCGCTGGTCATCATCGCGAAAGCCATCCCGCAGGTCAGTCAAAGTCACGGTCGGACAGTACCAACCGTGCTCACCAACAGGCGCTATGAGGTCATTCCGTTAGGAGTTCTTAGAGGGCGGTTCGTGAGCTGATGTCCATTGCCGGGTGAGGCTGGGAGGGGGCTGCTGTGATGTCGACCTGTAGTTGGTCGTTCCGGTTCCGAGCCGGCCAGTGGGCGGACGCGTGATAGGGCGGGCGGAGGCCTCTGGCAGCATGGGCTTGTGACTCATGCGAACGACTCGGACGACCCGCTCCAGCTGCTGATGGGCTTGGAGGTCAGCGACGTGTCTTTCGTGCGCGACTACGTCGAGCTGCACTTCGATGGACCGATTCTGCGGGCCTTGAGCGACCCCTCGGGGGTGTACGGGGGCCGCGAGTGGAGCTTTCCCGCACCAGGGTCGTTGGAGCTCATGCGCTGCTACATCGGCGAGACCGTCGACGGCTATGAACTGGATCCGGACCGGATTCTCGCCCTGGACTTCGGAGAGCACCGCTTCGTCATCCCGCTGGACTCCGATTCAAGCGGCGGTCCCGAGGCCGCCCACATGGTCGACGTCGACGAGAGCGGTCGGGCTTCTGTCCTCGGCGGGATGTGGATCTGGTAGCAAGAGGGGCGCCGATCCGGGGTGGCCGATCGGTCGGGGTCACAGCTGCTGGTCGTGGTGCCCGGCAGCCTGCTGCTTCCTGGTGAAGCTGCCGGTGTCGACCTCGGCAAGGATGTCGAGCTTGACCAGGCGTTTCAGCTTGGCGCGGGTGCCCTCGATGTTCTTTTGCAGCAGTTCGTGGTCGAGGGCTTCGCAGACATCGCGGGCCCGGAGCGGGCTGGTGGCCTCGTTGAAGGCAGCGAGGATGCGGGGGTAGTCCGGGTGCTCGGGCAGGTCCGGCGGGGCGGCCGGGAGCCGGTCGGCGAGGGCCGTGACGGTCTTCCGGGTAATCGACAGGTGTTCGAGGTGGATCTCGGCTTCCCGCAGTCGGCCGTGCAGCTCTTCGATCTGGGTGCGGAGGCCGTCGGCCAGGGCCCGGGCGGCGTCCTCTTGGACGACGAGCGCGTCGAGGAGGGGCTCGATGTTCACGCTGCCACCGCCTGCGGGATCACGCCAGCTGGGGGTGTTCGCGTTGGTGAGCCGTCGGGCCATGACCTGGGTCATCGCCCAGTAGACGCGGGATGCCGAGGAGGCAGGGCGGTGCTCGTAGTCGCGGACCAGGCGCCGGTGCAGTATCAGGATTCCGTAGGTCTGCTCGACCCTCCGCCGCTTCGGCTGCGGGACGAACCCCCTCTCCTGCGGGTTGCGTTCGACGATCTCCACGTCGATGCCGAGCGCGGTGCCGTGAGCGACCACGGCCGTCTTGAAGCCCTGGTCGACCAGGGCTCTGCGGACAGTGCCGCCGGTGTGCTCGGCGACCTGGTCCAGCAGGGCGATGCCGGCTGCGTTGTCGTGGGTGTTCGCGGCCAGGACGATGACGGCGATGACCAGGCCCAGCACGTCCACGGCCAGTCCCCGCTTGCGGCCCGGCACCCTCTTCGCCGGGTCCCGGCCGGTCGTGGCCGCAGGGACCCCAGCGGCCGCGTGGACACTCTGGGTGTCCAGCACCACCAGAATCGGATCCTCTAATCGGCGAGCTCGTTCACGGACCTGGCAGCGCAGGAGCTCGTGGATGACCTGGTCGGTGCCGTCGTCCCGCCAGGCGGCGAAGTAGTAGTACGTCGCGCTCTTCGGCGGCACGTCGTGCGGGAGGTAGGCCCACTGGCAGCCGGTCCGGCCCTGGTAGAGGATCGCGTTGACGATCTCCCGCATCGCGTAGGCACCCTGGTGACCGCTGACAGAGCGATGCCGGTCCTTCCACGCGGTGATCACCGGCTCGATCAACGCCCACTGCTCGTCCGATAAGTCGCTCGGGTACGGCTTGCGTTCACTCACATCATCACACCAGCAGGCCCCCGGCTGCGGACCGGCGGATTCCGCCCTGCACCCATACCATCAGGCGACGACAAAGCCACTCAAGACCTCACGAACCGCCCTCTTAGACGTGCCGCTGCGGTGGCTGCGTGATCTGGTGTTGTTCGGTATTCAACGTGTATGTTGAGCGCCGCCAGCTCCCGGCAGTGTGAGAACCCCACTTCACCGCACCAAGTTGGGGCTTCCCTCTCACTTGCCACAGGAGCAATCCATGACTGCGCCCACACCTGCCCCCGGCCACCCTCAGCGGCCCGATGATGTGCCCGCTTCCGCAGCGTCGGAGGCCGGCCAGCCGTTCACCCCGCAGCTGGCGAACGGCCCTGGCAAGCCCGACAGCCAGCTCAACGCCAAGCAGAAGACCGTCCTCGGGTGCGGGGGCATGATCGCCCTCTTCCTGATAGCCACGATGTTCGCCGCCGCGGTCTCACCTTCCGACGCCAAGCCCGCCGAGGCCAAACCCGCCCCGACCGTCACCGTCACGGTCACCGCGACCGTCACGGTCACCGCGCCCCCGCCCGTGGTGGCCAAGGCTCCCGAGCCGATGCAGGAAGCAGCACCGCAGACGGCGCAAGTCCCTGACATGACAGGCAAGTCCGGTGACCTGCTCGTAGAAGCCCTCAAAACAGCAGGGTTCGCCGACGGCTACAAGGCCACTTCGTTCCACGATGTCAGCGGCCAGGGACGTACGGTACTGCTCCTGACCAACTGGAAGATTTGCGACCAAGACCCGAAGAACAAGGCCGTCCCCATCACTGAAAAGGTCTCAGTCGGCGTGGTCAAGTTCGGCGAGGACTGCCCTTAACGTCCCCTGCTCATGGTGACGGCCACCGTCGTGCAGCCGTCGGCAGCGCGGCGGCTGAGGACCCGCGAGCCACCAGCGGGGCAGGGGCGGGTAAACCCAGCCGTCCACTCGCCGCGTGCGGTGGACGGAGCGCTTGCGCCGCAGCGGCCAGGAGCGGCGGCGGTGAACCACGGCGCTACTCGCTCGCCCGGCCTCGCTGGCAAATGATGTTCTGGCCTGCGTCCCGTGGGCGGATGGCCCGCATGCCGGGCGCGGCGGACGCCGTTGGTCCTCATCGCTACGATCCGTCAGTCACATTGACGCTTTCTGTTACCGAGGAGTCTGCAGTGGCCTATGGCCAGCCGCCCTACCCGTACACCCCTCCACCGGCCCCGATACGCCCCTGGTGGCAGACTTCGGGAGTCCGTCTCGGATTCATCGGCGCGGCCGCCGTCATCATGGCGATCGCCCAGGGGCTCGGCATACTCCTCATGTTCGCGTCCATCGCCATGATCTGGATCAGCACGGGCGGGTTGAGGCATCCGTGGCAGGTGTGGCAGCGGATCGCCGCAACGGTCGGCACCCTGATGCTCTGCCTGATCGTGGCCGGCATCGCGCACCCGGTGAAGAAGAAGGACGACGCGAAGGCCGCAGCGACGCCGACGACGGCTGCCACGTCGAAGGCATCGGAGACGCCCGCCCCGGCGGCTGTGCCGCAGCTGTCGGACTACACGGGCAAGGCGCTGACCGAGGCACGCAAGGGCGCCGAGGCTGCCGGATACACGGTCGGCAACCGTGACGCCTCCAGCGAGGCCCGCGGGGTCGTCCTCGCTGGGAACTGGACAGTGTGCTTCCAGAAGGTCTCCGACCTGGCCGGCGGGAAGAAGGGCGTGGACTTCTCCGTGGTCAAGGAGGGCGAGCCGTGTCCGAAGGAGGACGGCGGTGCGCTGCCGTGGCCGGTGATGCCTAACGTGGTGGGCGCCACCTACAACAAGGCGATGGCGGATCTCAAGGCGGCGGGCGTGCCGCTGGAGCGGGTGTCGCTGGAGGACGTCTACCTCGACACGGACACGCCCACTGCGGAGCAGGCCGCGAAGGACGGTGAGGAGTGGCACGTCTGCTTCCAGGACCCGGGCAAGGACGGCAAGGTCACCTCGACCACCACGGTCCGTCTAGATCTGGGCAGGTGGAGCGAGGCGTCCCTGGTGAAGAGCTGTCCGGCCACGAAGGGCACCACGTACCAGATCCCGGCGAACGATCCCGACTACGAGCGCCCCGGGACCTCAACGGGACATGACGATTCGTCGAGCTCAAGCGGGTCGACAGGCGGCGGTGCGAAGACCGTGCATCCGGGGGCGTTCTGCTCGCCGGGCGGAGCGGTCGGTACGGCGAACGGGAAGACGTACACCTGCAAGGGCCCCGGTCAGAACCGCTGGCGCCAGTAGCCTGCACCTCGAAGGGCCCCTCCGGCCGCCCAGCCGGAGGGGGCCCTCTTCGGGCGGTCGGGCGCGTGGTGCACAAAGAGCCGGGCGAGCTGGCTGCTGGTCTCGCCTCGCCTGTTCTTGACGAGTAACCATGTCACGCCCAACGATAGGCCCCCCTATCCGGACTGGCCGCCTGGTGGGCCGGCCTCTTCGAAGGTGCACGCGAGCCGTGCCCACCCAGGCGGCCCATGCAACGGCGCACCGTATAGCGGAGGACCAGGCTCGGCTGCCCCCAGAAAACACCTTCCGGCCACTGCCATCCCGTCCGTCCGGACTTGCCAACCCTTAGGAACAGGACCTCCCCGTGAGCAACGCCCTCGCACGTCTGCTCGAAATCGCCCCTGCGCCGAGCCAGCCCCGCGACAAGGCGTGGAGCGAAGTCGAACGCACCCTCGCGGTAGAGCTCCCCAACGACTACAAGGAGCTCATCAGCGTCTACGGAGGAAGCAACTGGGACGACTACCTCTATATCCTGGAGCCCGGCTGCCCCAACAGGCACTACGACCTCCTCAAGTGGGCCGAGTACCAGTTCCGAGACCTGCAAGATCTCTGGACGTTCGAAAAGAGGCCGGCAGAACTGGAGACCGAAGGATCCGTAGTTGTCCCATGGGCGACCACAGACAACGGAGAATGCCTCTACTGGCTCGTTCTTCCGGGCGTTGAGCCGAACGAATGGACTGTCATGGTGAACGAGGCGAGGGGCCCCCGTTGGGAACACTACTCCGTGTCGTGCACGCAATTCCTTGCGTCCGCACTCACCGGAGAGTTGAAGTCCAACATCCTCTCCTCATCGTTCCCCCTCGCCTCCCACAAATTCCGCCGCCTCAGTCCGGCGTGACGAAGTAGCCCGCTCTGCTGACACGGACACCTCGGCCTGGACGGAGGCCGAGTGATCAGCCGCTGCCACAGCGCGGCCGTACCGGCCAGCGGGGCCCTGAGCGAGTTCGGCGTAGGCCTGCTGCCACGTCCCTTGGAGCGTGATCAGGTCCGGGAGACGGATCGGCGGTCTCACACCCCCAAGCAAAACGAAAGGTTTGATCTACCGGGCGACCATCCAACGCTGCCATGGGCCGTACGTCTGGTCGCAGGGCGCGGCCCCGGAGGAAGCGCGTCCAGGCGCACGCGCCAGTCTCCACATCGTCGGCTTCTACCCAACTCAACCTTGCCGACAACTACCGGCAGCTCGCTCCTTCGAAGCTGCCGAGCACATCAACGCTGCCACAACGTACGCTCCCAGCCTTCCACAGAATCCATAGAATGACCTCCTTCGCGGCTCCATCCAAGAGGGCGCTGAGGCCACCGTAGGCGGAATCCGTCAAGGCGAGCCTCCGCGCCTGGTACCGCTGCGAGCGCCCAGATTCCGCTGACAGCCTGCGAGGGCGGCGGCGCCGGTGACGGCAACTACTCCGTCCGCTACATCGCCAAGAACCACAACCTCGCAGTCCGGCCCTCCACAAGGACTTCCACCGCGACGAGCGGGTCCAGGCCGCGAAGCGAAAGCGACCGACCTCTACTCCAGCAGCACAGGCGGGCCCCCGGCCTCGCCAGCGGCCTGCCACACATGAACCGCGTACGTCTCCAGCCCCTCCGCCCCGCCCACGGCTCCCGGCCGTTTCATCGGGAACCGGTACACCCGCAGCGCGTACCGGGCCGGCCCGCCGAGAGGGATCGGCTCGCCCCGCGGCGCACCCCAGAAGTCGTACACGGCGAAGATACCGCTGCGCACCGCGATCGACGCCTCACCCAGCGGCTCCTGCCCGGCCAAGACGGGCGGCGCCTCGTCCCAGACCTCCACCAGGACATCCACATCGAAGTGCGTGTGCACCAAGCTGCCGATCCCGACCGCGTACTCGCCGACCGCCAAACCCCCGGCAGCCGGGGGAAGCTGCTCCATCACGGTGTCGTCCAGCAGCGAGAACGCACCCACACGAAACGAGGCGTACTCGACGTTCGTGGAACGCTCCGCGCTCCAGCAGACTTTGGCCATCCGACCAGCTTGCCAGGCCCCGAGAAGCCCCGCGCGCGCGATCGCGACAAGACATGACGACCCTCCGTATCGACGCTCGGCGACGGCCGCGCGGTCGAACGAACGCCGACCGGCTCGCGCCGCCGGAGTCTGCGACCGCTCGCAGTGCGCTGACATGATCATCATGTCGCAGGGCCATGCCCGAACTCCACGGGGGGCCGGTGTTCGGGCGGACGCCGCACGTCACCTCCACTTAAACCGGGCCGAGAATGGCACCCATGGACCCTCTGTTGCACCTCGACCGTACGCTCGACGACCTCGACCCGCCGCGCTGGGAGGCCGTGCCCGCCAACGCGACACGGCTGGTCCGCACGGTGCACGGTCTGCGCCGGGTCCCGCTCGGCGAACTGCGACCCGCCGACCTGCGCACCCTCCTCGCGCAGCAGGTGGCGCTCCCGTTCGTCCTTCCCCTCGCGGTGCGCCTGCTGGCCGAGGAACCGCTGCTGGACGCCTACTTCTACGAGGGAGACCTGCTGCTCGCAACCGTCACGGCCCCCGAAGGGGCCTGGGCGGCGCTCCCGGAGCTCGAAGCGCGGCTGCGCACCATCGTCGCGGGGCTGCCCGGGGCGGCGGTGAAGGAGTTGCCGCGGGGGAGTGACACGGACCTAGCCCGGTTCATCGCGCGGGGCTGATCCCACCGCGCGGGGGCCGTCAACGTCGGCCGTGCTTGGTGTGGAGCCAGCCGTGTCGACGATCAAGCAGTGACCAGACGCTTCCCGCGGGGCGCGCTGCAGCCCGCACCGAGGACATCTTGCAGGCGCCGCCCTGGCTTCACACCCGGCATCATGTGGCCCCCGCCGTCGCTACCGCCGTACTGTTCAGTGCGCTCGAATGCGTCTGAAGGGGGACACACCCTTGCCGGACCGCAGTGCCGAAATGCGTGCGAAGACGCTCGACCGCATTGCTTCGTATCAGGAGTCCAAGGACCGCTGGAACCTGTTCCGGAGCCTCAAGAACCTCATCGAACAAGCCGTCCGAGACTACGAGCATCGCGCCTTGGTGGAGCTCCTTCAGAACGCCCACGACGCGCATGACGCCGATGACCCCGGCGGCAGGGTCCTGATCAGGCTCGACCACGACGAGGGCCCGCACGGTGCGGTGTACGTGGCGAACACCGGACGGCCCGTCAGCGGCAGCAACTTCGACGCGATGACCTACATCGCACAGTCGGACAAGCGACCGGAGGAAGGCATCGGCAACAAGGGGATCGGCTTCAAGAGCGTTCTCCAGCTGACCGGAGCACCCCAGGTCTACTCGGTCGCCGGGGCGGGAAGCCGGGTCTTCGACGGCTATCGCTTCACCTTCGCCGACGAGACCTCGCTCAAGGATCTCCTGGGCGGCGACGTGACCCTCGCAGCGGAGGTGGCCGCCGACGTCTTCCACCTCTGTCTGCCTGTCCCCCTCGACGGCGTCCCCGACGCCGTGAACGGCTTCGCGGCCGACGGATACGTGACCGTGCTGCGCCTGCCGCTCAAGAGCGAGGAGGCCCGGGCCGAGGCGGCCGAGCAGTTGACCGCGCTGTCCGCCGACCCGCCGGTGCTGCTCTTCCTGCGCCGCATCGGGTCACTCACCATCGAGGAGAGGCAGGACGGGGAGGTCGCTCGGCGCACCCTGGTCCGGACCGAGCGGGTGGACGCCGTCCTCGACCGGCTCACGGTCAGCACGGCACGCGTCGCCACGACCTGCTTCATTCTCCGAGTGCGAACGACGCCCGTTCCTGCCATTTCACACCGTCGTGCACCATCAGTTCAACCGACGCGACATGAGACGTGAACGGGAGCTTGTCGGCGAGGTCGGCCTCGATCTCCTCCAGAACGGCGTCTTCCTGACCTTGAGCGATGGTCAGGTGCGGCACGATCTCGGCAAACCGGCCGCCATACGGCGGAGCCTCAGGCCAACGATCAGCGATCGCCTCCGTGAGCTGCCGCAACTGCGTATCAGGCTCGGGGACGAGATACAGCACTTCCGGGAGACGCCCACACCTCTCGAACCGCAGATCAAAGGCCGGGTGGCTGGCCAGCACGTCCGCGAGAGCGGAGTAGACGAGCGCATCTATTCGGCTCTCATCGAGGAACGGGAAGAGCACGGTGACGTGGGCTGGAACCCCGGCCTGGGCTGAGGGGTCGAGCTGTTCACGCCACCCGCGGACGGACGGCTCCGCCTCCGGGATCCGGACGATGAGGCCCGTCTGGCCCGCCTGAAACGTACTGGTGCTGTCATCTGCCATGACACCGCATGGTGTCACCTCTGTCGCAGACAGCACGGCTCCTTTTCCGCCGAACGATCACGACGGGTCTCCGAAGCCGGTCGACGGGCGGGACGACCAAGGTGCTGCCGTTATGTGCCGTGAACATCCAGAGTGCCGGTGATCACTGACCGCCGCCGGAACCCACGAACAACGCTGTCGGTTGACGGGTTCTGGCACGACTTTCGTGAAGCGGTCGCGATTAGTGATCAGTGGGTGTTTCGAGTGCTTGGAGGATCTGTCGCACTTCCTGGCGCCACTGGTTGGCGTCAGCGCTGTCCACCCAGCCGGTTGTCAGTTCTGATCCGTCCTGGAGAACCCGGTCCAGTGCCAGTTTCGCCGACGCGCGAAGGGAGGCTGGCAGTTTGGGCAGCGGTTCCCTGGGGCCGTCATCGGGGTCGATCACGATGGGGCTGTCTGGGAGGGTGCTGGCGACGAGGGCGCCGGCGGCGACGGCTTCGGCCCCGTCTCCGCCGTCGACGCGTTCCTCTGAGTCGGTGACTCGCTGGAATGCCCTCTCCAGCAGGGCGATGACCTGCTGGTGGGCGAGCCCCTCAAGTTGATCGACGAAGTCTGCGGCGAGGTCGCTGTCGAACGGGCCGGTTCCCCACGTTCCCATGCATGGCTCCTGATACGGCTGTCTCGGACGAAGGCATGGTTCCAGGAGCCACTGACGTCGGTCACGGGGCGAGGAGGACCCGCTTGCGGAGCAGTGTGAAGCCGGCGCGTCCGAACATCTGGCGCTTGAGCATCTTGATCCTGTTGACGTGCCCTTCGACAACGCCGGAGCTCCAGGGCAGGGTCAGGCCGGCGATGACGGCGTCGCGGTCTCGGTCGATGCCGGCCGCGAGAGTGTGGGGGGACTGGGAAGAACGTCCCGGCGGACCGGCTTCGAGCCACTGCGGGAGTCGTTCCCCCCTGCCGCTCGGTGAGCACCCGCCGATGAGCGCGCAGCCCGACCACGCCCCATCACGCAGTACCCCGCGCCCGGCGCGCAGCTGGCCGAAATTGACCATGAGGGCCCCTTGCCGATCACCGAGGGCACCGGGATTCGGTTGACGGTCGCGAAGCTGCCAAGCGGCGGGGTGAACAAGCCCGCCTGGCTCTGGTGGTCGGGCACCGGTGCGGGCCCCGAGGACGTGGATCGGTGCTGGCGGGCGTTCCTGCGAAGGTTCGACGTGGAGCACACGTTCCGCCTGCTCAAGCAGACGCTCGGCTGGACCCGTCCCAAGCTCCGGGACTCCGCCGCGGCCGACCGCTGGACCTGGATCGTCCTCGCGGCACACGCCCAACTTCGTCTTGCCCGCCCGCTCGCGCGCGACCTCCCCGGCCGTGGGAGCGACCAGCGGAACCGTACAGACTCACCCCCGCCCGAGTACGCCGCGGGTTCAGGAACCTGCACGCGCAGACCGGCACGCCAGCCCGTGCACCGAAACCCAGCCGACCCCGCCCCGGCCGCCCGCCCGGCTCGAAGAACAAGCGGCCCGCCACCCGCTACGACGTCGGACGCGTCCTCGCCACCGGCGAGTCCTACACCCGACCGGCCCACCACAAGGTCGGCACCAAACCCCGAAGAACTGGGCAACCGGCAAGCTGAGCTGCCACCCCAGCCTCATCGCCACGACACCGACGATGTTGGATAGCCGCATGGTGAGACGGAAGAAGGAGAAGAAGAAGCGGCCCGACTGGGGCATCCCGAAGGGGATCGTGCTGTTGGCGACGCCAGAGGGCTGGCGCCACAGCGTCCTCACCATGGAAGGCGGCATGCTCTGCGGGCGTCTGGACGTGCCAATCAACACCGATCCACAAGACGCGCGAGCCGCGGCGGCCCGGATGGTGACGGAACTCGCGCGAGACTTCCACGACACCGACGTCGAGGTGAGCTGGGATCCCCCTCGGGAGCCCTGGTCATGGACCGCTCAGGTCACCCTCCCCGCCGGAACCGAACCTTCCCCGCCAGACTCCGAAGGTTAAATCGCAAGCTCAGTGCCTGTTCGAGTACGCCGCTACAGTTCCCCCGTCGACGTCCGGGGGCCCCGGTCTGAATGAGGGGTGGGAACGTGGAGAAGACCTGGTTCGAAGAGGTGTTCCGCAGGAGACCGCACCCGATGCTGCGCCTGCTGGGCAACCTCCTGCTCGGTGCGGCCCAGCTGGTATTCGTAGTCGCCGTGATCACGCACTTTCACAGTGACTGGCGGTGGCTTGTTGTCCCGATGGGGCTCTGGGCGATGCTTGCCGATGGCCGAGGCGTGGCCTTGGCGGTGCAAGACCTTCGGCGGCGCGACCCCGCCCCGGCGCCAGAGTGAGACGACCTCCGCTGGCTGGCCACCTCGGGGTCATGCCCGTTTAGGAAGGACCGGGCCTCGGCCGACTCCGGCACTGGAACGCCGGCGACGTCCCGGCCGACGGCTGCAACACCCGCGCCGAGGTACTGCTGGCCGAGGCGGTCGTGTATCCGGAGATCGGGCCGGGCTGCACCCTGACCGGCGGGGTGTGGTGGTTGTACTACGACGAGCGGGAGGTCACGCCGGCCGGTGCGCTGGACATCGACCACATGGTGCCGCTCGTCGAGGCCTGGGACTCTGGGGCGGCGGCGTGGACGGCGGCGCGGCGGGAGGCATACGCGAACGATCAAGGTCAGCTGGCCTCGCTGGTGGCGGTGACGGCCCGCTCGAACCGGAGCAAGGCCGACCAGGACCCGGCGCAGTGGCTCCCGCCGGCGCCGGACGCGCTGTGCCGGTACGGCGCCGAATGGACCGCGACCAAGCTCCGCTGGGGTCTCGCGGCCGACGAGGCGGAGCGGGAGCGGCTGCTGGACATCGCTGCCGGCTGTAGCGGCACGGACGTGGAGTTCACCCCCGCCCCGTAGCGCCAACGCGGACGGTTTGACGGGGCCGCCACCGCCGACGAGGGGGGCGGCCCCTTTGTCTGTGGCGCCTGCGGTCAGGGGTGGAGGTAGTCGTTGAGGTAGGTGCGGGCCGCGGCCTCGCTCGTACCCAGCGCGGTGGCCAGCACTGTGAGCGGCACGTCGCGGGCGCCGTGGGCAGACTGGGATCAGCCCGGCTCGGCCTCCGGAGGGTAACGGGGGTGTTCGAATGCGATGGAAGGAGCGCGAGGCCGGGTCTGTCAGCGTTCACGCATCCTGGTCCACCACCAGCCGTGCATTGCCCACTCGGTGTAGTTGGGCTCCGGCAAGGTGCGGCGCTCGAATTCCTCATCGATGCGCGTGATCAGTCGACCCAAGTCCCGTTGGGCTCCGGGAGGAAGGTGCAGCATCGCCCGCTCCAGATCGTCACGGGCGTCTTCCACCTCTATCCCAGGCGAGCATGCCTCGGAGGCGTTCAGGTAGCGGCCAGGTTGCTTGAAGGCCCACTCGAAGCGTGAGAGCGCATCCGCGACCGCGTTGGGCCACATATCTTGGTCTTCGACCCGGCGGATCGCTGCACGAGTCCGCGCACTGACACCGCGGACTTGCAGGACCGGGTACTGCCATCGTGGCCGAAACCGCTCTGCACGGACGGCCTTGGGACGCCTACGCGGCATCGCCCTTTCGGATCAACATAAGGCCATCCTGCCACGGCTGGTGCCCGGATGGGGTTCCCACGGGCCCGCCGTGGTCCTGCGGGCCCGTGGGAACCGGGGCAGGCGGGGTCAGGAACGGGCCGGCGCCGCTCCCCGGCCTGCCTCGCGGCCGCCGACGAGGCCCGATCATGCCGTCGACCGCACGGAAGACGGAACCCCTTCTTTCCGGAGTGGGCGGGGAGCCGGCGCGCCGCCGTGCTCGGGTCCCAGCCGCGAGACCCCGCACGGCCCGCATCCGCAGCGGGTGCCCGGACACGCCCCGGGGAGCCCGGGCCGCAGCCGGCCCGGCCCCCTCACCCGTCGGCCTGGTGGCGTATTCGACGGCTCGGGCTACTCCGCATTCCCGCCGGTGACCCGGGAGTACGTCTTCGGGTCGGTGGCGGCGATGCGTTCAAGCGCGGCAGCGGCCCGCACGCCCGGCCGGCGCCCGTCGTCGGGCAGGCGCCAGGTGAGGCGGACCCACTGGCCGGCTTCGTCGCCGACCGGGTCGCGGCCGGCGCCGGGCCCGTACCAGAAGTCCACTTCGACGGTGTCCTCGTACGGGCCGGCCGGGCGGCACCAACTCTGCAGGATGCCCCAGCGGGCCAGCAGGCCGGGCCGCTCCCCGAGCCCGGCCTGGATGAGGCGGGCGGTGCTGCGCGCGGGCCGGCACCAGGTGTCGTCCGCCCGGGCACGGTCGACCTCGGCGTGGTAGGCCGCGGCGTCGAACCGGTGCTCGGGCAGCTGTGGTCCGATGCCGTTCTGACGGGGCCCGTGCCACACGACGTGGGCCCCGTCCCGCCGCACGGTTACGGACAGCGTTCCGCAGCACCCTTCATCGCACTCCGCCGTCGACAGCGTGACGGTGCGTTCCTCGGGCGTCGCCCGCAGCAGGTCCTGGCCGAGGACGTGCTCCGGCGACGGGCTGTGGCCCGCGGGGAACAGACGGGGCACCAGCGGGCGGCCGTCCAGCAGGATCCGGGCCTCCACGTGGCCACCGATCTCCGGATCGTGTTCGACCACGTGGATCCGCAGGCCGTTCGGCGTGGTGCGGTCGAGGGGCTCCCGTCGCATGCGCCGGATCCAGTCGGCCCGGTACCGGTCGCGGTGTCGATGGCCGCCGTCCGGCACCGCCGCCCAGGCCGGGGTGCCCAGCAGGCGCTCCAGCCGCTCCAGCAGTTCCTCTCGCAGCCCCGGAGGCCAGTCCAGGAGTACGGACGCACCGCTGGACAGGTCCAGGGCGAGCGAGAGCAGGATCGCGTGGTGGTCGAGGGTGGGCGGGAGCCGGTCGGCCCGTCGCACCAGCGCCTCGTAAACGGCGATGGCCGGCCCGTAGCCGAGGACCTCGGCGGGGGAGCCGGTCGCCAGCGCCATCCGGGTCAGCAGCCGGCCGCCCTGCGCCAGGACGGACGCATCGACGGACTCGTCCTGCAGCAGGTCGGCGAGGCGGACCGCGAGGGCGATGTGGTGGGCCCGGGAGCTGGTCGTGCCGGGCCCCACGGGCAGGTTCAGCAGCCACCGACGGGCTGCCGGGTCCTCACGTGAGGCGAGCGCGTCGATCACCACGCCGTGATCCTGCGGATCCAGCAGGTCCATGAGCCGGATCAGCACCTCGGTGTCGCACCGTAGTGCCGAGAGGGCCGTGACGACGGGCCGGAGGAAGCCCTGCAGCAGGGCCAGTGTCGTGAGCTGGGGCACGTCCTCCGACCCGCCGAGGCGGCCGACCAGGTGGATTCCCGCCCCCAGCGCCGTCGGATCGGATGCCGTACGGACCAGCTGACGGCCCAGTGCGAGGGCTGCGGACTCGTTCGTCAGGGGCAGCCGCGCGAGGGGATGGTGCACGAGGTCCGGGCGCACACCCAGCTGGGGCAACCGCCGGTCCAGCGTTGCCGCTGCCCCGACCGGATCGGGGTCGTCCACAGCGGGACCGAGCAACTGGGCCAGGAGCCGGGTGGCTTCCCTGAAGCGCAGCGCGGAGCGCAGCCGGTCACCGGGCACCGGGTAGCCGTAGGCGGGAGCCCGTCCGTCCGGCTCGATGCCGCGGCGGAACAGGGCGTAGTCGTGGAGGGAGGTCGTCTGGGAGCGGAGCGCCGGGCGCTCTTCGCGGGCGCTCACCGGACGGGGCGCGACTCGATTCCGTAGATCATGTCCCGCAGCATGCCGCAGTGATCACCCGGCGTCCAGCGAAAAAAGATCGACCGTCTCGGGCCGATGCTCGCGCTCCAGCCGCGCAGAGGCTGCGTGTTGATCAACGCCACGCGCGGGCGCACAGCGCAAACGTGAGCAGGTCGGGAGTGCTGTGCGCCACAGCCCAGGAATCACAGCCCGACAAGTCCAGTGTTCATCGGACAGGTGCAGTGCTCCGTCACGACGCACCTGTGACTGCCGGCCTTAGTTGGCCCCTCCCGCCAACTACACCACTCAGCTTTCACGCCCGTTGTGCGGCTCGGCGGGCTGCGGAACCGCGCCGACCTGTGTGGCGTTCGGGTCCCGACCTGAAGACGAGGACGGGGACCCGGCCACCCGTCAGCCGCGGCGTCTGACCGGCTCTCCGAGCAGCTCGGTCAGTTCTGCCTCGACGGCGGCGAGCAGCGGGGGCCCCCAGACGGTCAGTGTCTGTTCCCAGGGGTGGCCGAAGGTGCCCAGGCGGAGGTCGTCGGTGAGGTGGAGGTAGTAGTCGCCATTGGGGTAGGTGCCTTTGCCGGGTCGGGGCGGCCGTCCGGGGAGGTCGGTGCGGCGGGGGTCGTAGCGATAGCCGTCGTGCTGCCAGTCGAGCCAGTAGACGAACTCGCCGGGCTTGGTGGCTGTGAGTAGTCCGCGCTGGACGATCGCGTCGATCTGTTCGGGGAGGTCAGGGACGGGCCGGTGGTGGGCGTGCAGATGCCAGACGGCGGAGGGAACGGGAGCGCTGATCGCGGGCAGGGACGTGGTGCTCGGCTTGAAGTCGAATTCAGTTTGGAAGCGGTCCCTCAGTGGACCGTCGTCGTGGAGCCAGTCGAGGAACTGCGCGGGTCGGGTGATCTCGGGGGTGCCGGTCGGGCGCCAGTGGTAGGAGCGGACGGTGGCCGCCTCCATGAAGCCGGCCTTCAGAAGCCGCTCGCGCAGGAGGCCTCCGGCCTCGGCGAGGAGGGGACGCGAGCTCTGCGTGCGCCAGTGGGCGGTGCAGCCTTGGACGAATTCTGCGTCGTCGCTGCTCAGCCCACCGACGACTTTGAAGGGACGGGTCAGGTCGGCGTAGACCCAGCCCACGGCGGTGACCTCGCGGTGCTGCAACAGGACGTCGATGTAGACGTCGCCGTCCTCCGAGGCGCCGTCGGCGATCATCTCCGCGTAGGGCACCGCGTGCGGGCCGGGGGAACCGACGGCGATCCCCCAGGCGCGTTCGGCTTGCTCCCGTACCGCGTACAGGCTGCGGATGTCGTTCCGGGGCTCCACCAAGACATCGGGCTCGCCCGGCAGCTCCTCGGCAATCAGCACGGAACGCTCCCAGCCCGGGGTGAACCCAGCCGCGGTCAGCGCTCGGCTCAGGTCCGGCGCATCGTGCCCGTACACCTTCCACTCCACGGGCTCGCCACGCTCTGCGAAACCTTCCTGCTGGTGGCGCACCAGCCCGGCGATGTCAGTCCCGGGCTTGAGGGGGGCGTGCTCGACCGTGCCGTGCGTCCCGTAGTGCCGGCGTACGACCGGCCCATCGGCCCGGACCACCACCCCGACCGGATGCCACGAGGGGACCCGTCCCCGCAGCCCGTCGTATTCCGCCCACCGCTCGCCCATGTCCATGCGCGGGAGCCTAGACGCGGCTCGGAGGCGCCTCGGCGTGAGGACCTTGGGGGTACACGCTTCGGGGCAGTTTTCCGACCATCCGTACGTGCAGGTCACGGGTGTCCCGAGGGCGGCAGGGGCCCTCTGGAACACTCATATTGGCCAGCTGTAGTTGACCACTGAGCGTTGTAGCTGGCCGGAGCCGCGCAACGGCGTCTACCGGCCGATCTCGAGTCGATCGTGCCGTCTGCGCGAGCGTGGGAGGGGAGGGTCCCGGCTTGGCACAGGCAGGAGCTTCGGGCCTCCTATTTGGTCGCTCGGGCCGAGCGGGGTTGCGCGCGCAAGGCAGGCAGCCGGGCGGTGTCTTCGGCTCCGGCCAGACTCTCGCCCACGGTCAGCAGCGAGAGGAGCCGCACCGGCCGGCCGGCGGTTGCCGCGGCTTCCAGTTTGTGGTGGCCGTCGAGGAGGAAGTGGGTCAGGCCCCAGTGCACTAAATAGTCGTCTCCCCGGTCGATGCCCGCAAAGGGGTCGAGTCCTCACAGCGGCTGGAAATGCATCGGCGTCCGCATCGCCCGCAAGGGCATCGAGTCATCAGAACGACTCGGCCGCCGCCGGAGGGTGATCGAGCGGGCCATGTCTGGCTCACCGGCTACCGCAGACTCAACCACCGCTACGAACGCCACCCCCGCAACTACCTCGCCTTTCTCGGCCTCGCCGCAGCCATCTGCTGCTACAAGCAATTCCTCCGCCTCACCGCATAGGACACGAGCTAGAAACACAGCGTTGCTCAGGGCTGAGAGCGGCGCCGGTGACGGGCAACGTGCACCGACGTTGCCGCCAGGACGGCGTCGGCCGGCGGGCCTAGTCTGCCGCGTAGCACCCTGTCTGGTAGTCGAGCCCGGGATCGGGTGGCCCACACTGCAGGATCGCGTCCACGGCCGGCCACAGCTCGATGGGCACGTCGTACCCATCGAACATCCAAGGGTCGTCCGCGTCGGGAGTGATCACCTCACGGAGTTGCATGATCTGTTCGCGGCCGATGGGAAACTCGGTGCGCAGGAAATCGTCGACCTTACTGAACCCCTGAAGGACCCACACGGCCCCAAGATCTTCCGAAGACATCCACGGATCGTACCGACATCGCCCCGAGGTGGCCGACCTTCGCCCGCCGCTACGGCTTCGACATCGAGCGGCCGGTCCAGTGGGAGGTGGAGGCGCTGGAGCCGGACGAACTCCAGCGCCTGGTCCTCGCCGCCGTAGACCCGTACATCGACCGCGACATCCTCGCCCGGGAGATTGCCCGCGAGGAGCAGCAACGCCGCGCGCTACGCGCCCGCCGGTCTCCTGCCACCGCACATAGGGGGAACGGCCAGGGCGGCAAGGTCATCGCCTACGAAGGTGCCACCGCTCCGTGGATCCAGCTCGGCCAGAGCGTGACGCCCGCCGCTCCGGGCGACATGACCGGCGACTAGAATCACGACCTCGTCGCGATCGACGCCACCGGCAAGCTGCGCCTCTACACGCCACGGGTACCGGCGCCCTCGGTACGCACAGCATGGGCAACGGCGGCCGGTCGGTATCTTCCGTGGCGCACCGCAGCGACCGGACCGGCGACGCTAAGAAGGACATTGTCCCCCGCGTCGGCGGGGAACTGCGGGTCTACCGGGTCGTCGGCGCCGGCGATGTCACGAAGGACGGCCACCCCGACCTCCTCGTCCAGCACTCCAACAAGCTGTACCTCTACGCGTCCATCGCGATGAGGCGGGCGGCGGTGGGAACTCGATCATGACGGCGCCGGGGATCTCGGAGGCGTAGCGGCGGCCGATGTCCTGGAAGTCGGCGACTTCGAGTGTGCCGATCCCGACCAGGGTGGGGACCGCGACACCTGACAGGTCGCCCCGCACGACGCCCTGCGAGTGCTCCCCGACGACGTCCTGGTTCACAAGCGACGTAACTACGTAGCGATCTTCATCCCTGCCAGAGAGCAAGCCCCACGGACCACAGGTTAAACGGCAAGCTCAGGACACGTCGCTCGACTAAGGGCTGTCCCGGAATCCAGTGCCGGGCTGGAGCGCCGCTACCCCAGAGCGGGAGGTGGCGGCTACTGACCTGACGCTTGCGTTCGACGCCCGCCCCGGGAAGAGTTCCGTCCTGCGGACGTCGTTCGGGGCGGGGCGTGGGAGCAGGGGCAGAGAGATGTGTGAGATGGACGCGGCGGTCAGAGAGGCTGCCGTTGCTCGGTTCCTCCGCGAATATCCGCTGATGGAGCAAGCTGCATGCGACCACCCCGCGCTGCTGGGCTGCGCCGACGTCGACTGGTCGCAGATTCCCGGGTGCCCTGCCGGGGTCCCGGTCCTGCTCCGCGGTCTCTTGGATGAGGTGGCCGGCCCTGCGGCTCTGACCGTGCTGGAGAACGTCCTGATGAACAGTGTTTTCCACGTGAGCGCCGTGATGCCGGCCGTCCTGCCCTTCCTGATCCGCCTGGCAGCCGTCCCTGACATCGCGGTGCGGTCCGGATTGGTCGACTTCCTGGTCGTCGCCGCGGAACTGTCTTCGTCCGTCGACGCCGACGATGAACGCCAGGTGCTGCTGTTCGGCAAGGACTCCGATCACCCGGAACGCGAGTGGTGCAGGGCCGCCTTCGCCGCACACGCGTCCGCCCTGCGCGCGTTGCTGGAGGACGGAACCCTTCCGGACGGACTGATCAGCGCGGATGACCGCGAGTGCCTGCTCAGGGCTGTGGAACCGCAGCGACGTCCTTCCTGACTGCCCGCTGACCGGCACCGCGGCCCGTGAAAAGACCCTGCGGTGTCTGGTGTGATCACGGCGTCGGAGCCGTCCTGGATAGCCCCGTTCACCGGGCTGAGCCCTCGCTGTTTCAGCACGTTGGTGACACAGCTGCGGCGTGAAGGAGCTGACGCGGTCCGCAGGCCGGCCGTGGGGCATGCCGCCGGAGGACCGGGTGCTGTTAGCCACGGCGTACTGGCGCACCAACTTGACGTTACGGCGCTCGCACCACTGTTCGGCGTCTCGAAGTCCGCGGCCAACCGCATCATCAGCCACCGTCAACCGCAAACGCCGCGGCAGTGAGGGCGGCCGGCCCACCGGCTTCGACAGCGAGATCTACAAGCGCCGCAACGAAGTCGAGCGGACGATCAACCGGCTCAAGAACTCCCGGGCTGTCGCCACCCGCTATGACAAGAGGGCCTACGTCTTCCACAGCACCGTCACCACCGCGGCTGTCCGGTTATGGCTCCGAGGCTGAGCCGGCCTGCAGCCTCAGTCCCCGAGGAACCACAGGTACAGGCCCTGTCCGGCGAGAACCACCTGACCCAGCTCGATCAGCTCGCGCGCGAACTCATCAGTCAGCACGCCTGCAGGCAGCCGCGGTACCTCCTCCAACAGGGTCGACACCTGCCGGTGGTTGAAAACGGTGTCCCCATACGGCAGCAGGTGTCCCAGCATCGGGAACACGGCCTGATCAAGACCAGCCAGCTCAGGACCCCAGAGCACACCGTGCTTCGCGCGGGCCTCGATCGTGCCGCTCTCGCCTCGGACATGGAGGTTAATCACGGTCAGACCCTACGGCCTTATGATCCGCCGGACACCCCCTAGCCGCTCGTCGTGCACTTCTCAAGGTGGCCGGCCCGTTCGCGCGGCACACCCCCCGTGGTTGTCAACCTCTGTGCCGGGCCGGGCGGCGTTGAGCGGCCCTTCGGGTGGCGGCTGCCAAGGTGGGGGGCGTGCCTATTCGTCGTGTTCGTGTGGTGGCCGTCTCGGCCGCCGTCGTCGCCATGGCCGCTGTTGCTGGCTGGGATCCGGCTGCTCTCCTTGGCCGGTCGAAGGCGAAAGAGGCGGTTGTCCGTGTCGACCAGTCCGGCTACGTCACGGGCGAGGTCAAGGTCGCCGCGGTCATGGGGGATGAGGAGGCGCTGGCCGGCGCGGGTTTCGTGGTCCCGTAGGGTGACAGGGACGAGAGAAGAGCACGATGGATCCCCGCATACCCCGCCTGCGTCGCAAGCTGGCCGCGATCCCTTTCCAACCCCTGCGCAGTCACTCCTTCGGGGAAGAGAAACACGAGTTTCGCCTCGGTCCGAATCGGCGCAACCGGCGAGATGCGCAGTCGTTGTGAGGGTGGGACGCACACCGCCCCTGGGAATCCATCCGTTCCCCCACGGGTCTCACCAGGGCGGGTGCGCATCCTGACCACCTGCACGTGCAGCGGCCCCTCGTCGGGACTTGACCTGGGGCCGGGGCGCGGCCGCGCATGGCGGCGGCGGGTGGTCAGGCAAACCACCAGCCCGCCTCGGCGGAGCTGCTGATCAGGAAAGATCTCGTGCATAGCGGAACGCCTTCTTCCCAGGCGGGAAGACAGCGATAGGTGCGGTGCCTGCACCCCCCGGCCGACAGCCAGGCCCGGCAAGACGCGGCGATGCACCGAGACGATCACTGTGCCGTGTGAAACCTCAGGCCGCCCCACGCTGTGCACGACGGCGCTACCTCCCGCTGCTGCCCGCGGATAGATTCCAGGCGTCCCCTCCGCAGGAGGGGCAATTCGGGCCGTCGGCCGGCCCGTTAGATGGACAGTCCATTCGCAGTTCTGTCCGCACCGATCCGTTCGGATCATTCACACTTTTCTCACGAGGGGGGACTCGTGCGCAGAAGAAGTGCGCTTCCAGTGTTTGCCATGGTGTCTTTGTCTCTGCTGCTCCCGCAGCAGATGGCCGGGGCGACACCTGCGGCAGCATCACCCGCGGCGGGGTCCGCAGTCGTCGATCCACCGCTGGCCGACGGCCAAGTCCAGCAGGTCGGTCCCGGTGTGTACTCGACGGCGGACAAGTCGTTCGAGATCTACGAAACCGATGTGGCAGTGGGCCTGATGAGCCGCAGTCACACCGTCACCGTTCAGCCGGACGGCGTGTCCAGGCCAGAGTCCGCACCGGTGGCCCGTGCGGACATGGGGATCTTCGGCCCGGGCTGGGAAGCTGAGTTCGTGGGTGGCCAGCTCAACCGCAAGCTGGAGCAGAGCGGCAATACGGCCGTCGTCACCGACCTCACCATGAACGCCGCGGCCACCTACGCTCTGAAGAGCAGCCTCGACTTCCCGGATGGGGGCGGCGTCAGGAAGTACGCGACCCCCGAGGGGGACACCCTCACCGAGACCACCCGGTTCAACGAGGCGACGGGCACGATGGTGTCCACCGCCGTCGAGAGCGCCAACGCGGCCACCTCGCTACCGGACGAGGACCTGTCCGCTGACGCCGATGCGACCGCGCCCAGCAATTTCGCTCAGCTGGCACCGACCTACACCTGGAAGCAGGTGGGGACTGGAGCCAACAGCTGGCGCGTCACCGGGGTTGGTACTGCCGCCAACAGCGCCCTGTCCACGGTCACGTACGACACCGCGGGTCGGGTCGCCACCGTCAAGGACGCCGAGATCGGGGAAACCACCTCCCGGCTCCTGACGGTCAAGTACTCGACCGCCACCACGGCCACCGGCACGACCCCCGGGGAGTTCACGGGCCGAGCCAGGGAGATCACCCTCACCGACGGCGCCACGGTGCAGACCCTCGCTCGGTACTCCTACGACGCCACCGGTCGACTCCGTTCGGTGGCCAACCCGGCCGAGGGAATCGACGCGGCTTCCTCGTATTCCTATGACACCACCGGGCGGGTCTCCGCCGTGGCTTCGCCGGCCAACGGCAACTGGGAGCTGACGTTCCCGGCCGGCTCGGCCTCGCCGAACGTCGAGCCCGTCGGTCCCGCGCGACCGGCTGCGGACGCACCGCTCGAAGGAGCGGGTGGGATCACCGACCCCGCCGCCGGCCCGCTGCCGACGGACTTCATCAACGGAGAGATCACCGACCCGCAGGCCTACCCGCGCCACTGCTCAGCCGCGACGGACTGGCTGTGGTACCTCAAGAGGAACTGTGCAGCGTGGGCTGCGCACTACGGCTGGCACAAGCCGACGTTCAAAACCACGCCGACCAACCACCGGGTCGTGGGCATCAACTACGACGGTTGCAGCACCCCCGGCCCCAACGTCAGCAGGCCGGGCGGCTTCAACTTCCGCACCGCGTGCGACATGCACGACTACGGCTACGGGCTCATCGGCAACACGTACAAGGGCTACTCGTACTACCTCGACCGGAGCAAGAAGTCGAACGTCGAGAACGCTTTCCACACCACGATGAAGACCTACAGCTGCAAGGCGTACTTCATCCTGAGGCGGCCGGGCTGCAACAACTGGGCGTATGCCTACTACAAGGCCGTGAGCAACCAGAGGTGGGGCGGCAACCCGAAGAACGGCGCTGACGCCACGTAAGGGCGCCGACTCTTTCCCACAACGTGCCATACATCAGCCGGACCGGGTGCGGCCGGGCATGACGGGGCCGGGGCGGAACCTCTCCGCCCCGGCCCCACCCCTCCGACCAGCCCGTGCACCATCTCGGCTGCCTCGCTTCGCCACCTCGGCATCGCTGCGATCCGAGTCGGGTCCCACGAGACGAGTCAGGACGCGCCCCGGCCGCCGCGGCATTTCCCTTGCAAACGACGGCCGACTGAACTGGCACAGCCGTGATGACGACGAGGTCCCTCGGCGCTTCGGATCGGTCCGTGCAGCCGCGCCGCTCACTCCCGCGGCAGCTGCGGAGCCACCCTCGGCGGCCATGACCCGATGCCGCCGGCCACATTCTTCCTTCCTGGTGCGAGCTCGCACCCGCCCTATGTTCATGGAGCAGCAAGTGAAAATTCGCATGGGCGGATTGGTCGCCGCCGCAGCAGCGGCCATGGTGATCACCGCGATACCGGTGGGCATCAACCCCCTGTCCGGAACCGCCACCGCCTCCGCCGAGGGCGGCGGACCGGTCGACCCTCCGCTGTTCGACGACACCCAGGACGGCGGGACCGTCCGGGTCAACGTCGTCACCGGCCAGCGGGCCGACCTGGCTTCCGCTGCCGGTGCGGGCGAGACCCTCGTCTCGTACGACACCCTGCCGATGGTCACCCTCCGCGTGGACAGGGCGGGCCTCCAGGAGCTGAACACCAGGCCGGGCGTCATCAGCGTCACCGAGGACGTCCCGGTCCCGCCCACACTGAACGAATCCACCCTCAAGATCGGCGCCGACCAGGCCGTCGCCGCAGGCAAGACTGGCGCCGGCACCGCCGTCGCGATCCTCGACACCGGCGTGGCCGTCAACCACCCGTTCCTCTCGGGCCGCGTGAGGACCGAAGCGTGCTTCTCCGTCAATGACGCGGAGTCGGGCGTCTCGAGTCTGTGCCCCAACGGTTCCGACCAGCAGGACGGCGCCGGCAGCGCCGACGCCGACAGCGGCCCGTGCGTCACCACGGGCATCGACTGCTCTCACGGAACCCACGTCGCCGGGATCGCCGCCGGCAACGGAGCCGGCATTGGCGGGGCACCGCGGCACGGTGTCGCGCCCGGTGCGGACATCATCGCCGTCCAGGTGTTCTCCAAGTTCGACTCCGACGACTTCTGCGGAGCGGGGATGAGCCCCTGCGTGCTCAGCTACACCAGCTCCCAGATCAAAGGTCTGGAGAAGGTCCTCGCGCTGAAGAAGGCAGGGACCAACGTCGTCGCGGCCAACCTGAGCCTGGGCGGCGGGCACTACACAACCCCCTGCGGCCAGGACTTGCGTACGGTCGTCGTGGACACCCTGCGTGCCGCTGGCGTTGCCACGGTCGTGGCCGCCGGCAACAGCGGTCACACCGCTGCCGTCAACGCTCCCGGCTGCGTTCCCTCCGCGATCACGGTCGGCTCGACCACCGACGACGATCAACTCTCCGCTTTCTCCAACCGCGGACCGCTGCTGGACCTCCTCGCCCCCGGCACGAGCATCATCTCCTCGCTTCCCGGCGGCGGCTACGGTTCGAGAAACGGCACCTCCATGGCCGCCCCCCACGTCGCCGGGGCCCTCGCAGTGCTGAAGCAGACCTACCCCGCGAAGAGCATCGACCAACTCGAAACGATCCTCAAGAACGACGGCAAGGCCATCGCCTACGAAGGCGCCACCACTCCGCGAATCCAGCTCGGCCAGAGCGTGACGCCCGCCGCTCCCGGCGACATGACCGGCGACAAGAAGCCCGACCTCGTCGCGATCGACGACACCGGCAAGCTGCGCCTCTACCCCGGCACGGGTACCGGCGCCCTCGGTGCGCACAGCATTATTGGCACCGGCGGCTGGTCGGGATCTTCCGTGACGCACCGTGGCGACTGGACCGGCGACGCCAAGGAGGACATCGTCGCCCGCGTCGGCGGGGAACTGCGGGTCTACCCCAACCGGGGCGACGGTACGCTCGGCGCGCATATCAAGATCGGTAGCGGGCTTCCCACCACCGCCCAGGTCGTCGGCGCCGGCGATGTCACGAAGGACGGCCACCCCGACCTCCTCGTTCAGCACTCCAACAAGCTGTACCTCTACGCAGGTGCTGCGGGGCCCGCGCCGTCCGTCGCCGCCCCCGTCATCATCGGCACGTCCGGGTGGGACGTCATGGACCTCACCGCCCCTGGTGACGCCGACCACGACGGCCGCGTCGACCTGCTCGCCCGCGACACCCGGGACGGCATCCTCTACCACTACCTCGGCCAGCCCGACGGAAAGACATTCAGCGACCGCACGGAGTACGGCCGCGGGTACACCAACGCTTTCCGGCCGCTGATCGCCGGCGCCGCCGACGCCAATCGAGACGGCATCGCCGACATGTGGGCCACCGCCGCCGACGGCACCCTGAAGTTCTACAAGGGCGACACCTCCATCCACGGCCCGGTCGACGGCCCGAGCATCCAGGTCGGCAGCGGCGGCTGGGGCGCCATCAAGTCCATCAGCTGACCCGGCCCCTCGCGGCTGCACGACGTTCCCAGGCGGCCAGGAGAGCCACCCACGCTTCCGGCCGGGAGCGCGGACAGAATGCATGTCGGCGTGGGCCGCCGCCACCCGGTGGTGGCCCACGCGCCGCCAGCTGTCGAAGACAGCCACCCATGTGATGTCCGGCGATGAGCGGTGTCCGACGACTCGCCATCCCTCACGAAGGGACGGCTGCCCGCCACGGTTCGCTGCCGCCATCCAGATCCAGGACGACGCCCCGGTGCCGGACGCGTACGCGGTCGGTGAGGAGTCACGGGGCAGCACGGTGCCCGACACGCGGTCGTCGCCCGCCCGCAACTGGGTCAGGCCGACCGACCCATTGCCCGGACACCGTCGCCTGGACGGTGATACTGCCGCGTGGGACGTGGCCGCAGTCTGTCCGCGACGGCGCGATCATCGAACCTTGACCGCCCTGGTCAGACTGTTCCCGGGGCCGCCGACTGCTTCGCACCGTCAGCAGGCTCGGGTGCCGCCCGGGGGCTGGAGCTGAACTGCTCGCCGATGTTGTTCCACATGAAGCCGTCCTGCCAGTTCGGCTTCGCGGCTGCACAGCCGAACACTGCCACGAGGACCTTCTCCTGGGAAACGGTCATGGTCTGGAAGTGCTGCTCGGCCCCGCCGTCCCGGTATTCGAGCTGGTAGGCGTTGTTCTCACGCAGCAGGACCTGGATGTACCAGCTGCCGGGCAGTTCCTCGTCCACCCGCTCCACGATCAGGTGGGCGTTGCCCCGCCGCAGGTTGGCCAGCATCGCTCCGATGGCGGGCTTGGTGGCGCGCTTCACCACGTGGCCGAGTTCGTTGGTCGCTATCAGCATGGCCGGATCATCCAACAGGGGACTGACACCGCCTCGTGAGGCTCGGACCTGGGCGGTCAAGGTTCGATGGCACGAACGGTGCAGTGGTCCAACTTCAGTGGCAATCGGTCAAGGATCGGTGGCACACGACAGCCTGGCTGACACGCATCACCGCACCCGCTCTCGCGTCCCGAAGTCCCGCGAGGTTAAATCCAAGGTTAAGAAGTGCCGGAATCTGAGGTTAAGACACGCTAGGGTTGGCCTATGCCAACCGAGGATGAGCTGTTCGCGGCCGTGGATGCCCTGCTGACCGGTGAGCCCGAGATGCCGCAGCCGGCCGAGCGGGCCCGGCTGCGCGAGGCGGCCGGTGTCACCCAGGCGCGTCTCGCCCAGGTCCTGCAGACCACGACACAGTCGGTGAAGAACTGGGAAGCGGGCCGTTCCGAGCCGCGCCCGCCGCGCCGTCAGGCGTATCAGCGGCTGCTGGATGGCTGGGCCGCCCAGCAGCCCACCCGCCCGAACACGCCCGTGCCCGCCGCGCTCTCCGGCACGCCCGCTCCGGCCGCTCCGTCAGCGGAGCCCGTCAGCCCGGCCGTTGCCGAGGTCCCGATCCGTCCGGCGGCTTCGTCACGGCGCCCGGCCGCGAAGGAGGCTGCCAAGCCCGCCACCAACCCGGCCGATCCCCGCTTTGCCCACGGTCCGCTCGCCGTCCTCGACGGCGACGGCAACGCGTACGCCGTGAACGGCATCGTGGTGGACTGCCCGGCCACCACGGTGGTCGAGCTGGTGGAGTGGACGCTGAAGGAGTCCGGTCTGGGCGCCGCGCGGCTGAACCGCAGCGGCAAGGACTCCGACCCCCTGATCGTGCTCACCGCCTCCGCTGCCGTGAAGCTAGGCCTTCCCGAGCGGCTGGAGGGGCGGGAGGAGCGGCGCTCGCTGCGCTTGGCGGAGGACCACCCGGTGGTGAAGCAGATCGCCAGGGCGAAGTGGCAGCTCACGCAGCGCGGTTTCGGCCCGTGGCCGCGGATCTACCGCAAGGCCCAGGGGAGCGCGCGGCAGTGCGTGCAGCTCGCGGTCCTGTCCTGGGATGCCCTCGACACCCGCTCCTGGCCGGGTGTCGCCGACATGGCTCCGGCTGACATTGCCCGCGTCCTCGGCGCGTACGCGCAGCGGGTCATCACCCCCCGCGGCTCCACCGCCGTGTCCGGGCTGGAGCTGATGACCGCGCTGCGCCCGCCCACCCGGGCCGTGCAGGAGAACGGCACCTGGGTGTCGGGCCACAACCCGGGCAGCCTCGGATCGGAGCCGATGGACCCGGCGCCGCCGGAGGCGATCGCCGAACACCCCGTCGTGGTGAACTCCGGCTGGACGGGCGGCTTCCTGAACGAGGAGGCGTACCAGTGGGTCCGCGACCCCGGCCTCCTCTCGGACGAGGAGTGCCTGCTGCCGTACGCGGTGGGCCTGGACCTGAACACGGCGTTCCTCGCGGCCGCGGCGCGACTGACGGTGGGCCTGTCGGCGCCGGACCACTTCCACCGGCCGGTGTTCAACAAGAAGATCCCCGGCTCCTGACTGGCCGACCTCTCCCACATCGATCTCGATCCGCGTCTGCCGTCGCCGTTCACCCCGGACGGCACCCGGCCGACGGGCCCGGCCTGGTACCAGACCCACACCCTGGCCTACGCCGAGGAACTCGGGCACGAGGTCCACCCGATCGAGGCCTACCTGCGCCGGGAGACCGGCGCCTACCTCGACCCGTGGCACGACCGGCTCAAGACCGCGTACGTCGACACCCTGGCCGACCTCGGCGTCACCGGACCTCACCGAGGCCGAGTTCCTGGCGGCGATGGAGCACCACAAGCAGGCCGACCCCGCGATGGCCGCCGTCCTCGCGGCGATCAAGGCGACGGTCAAGGGCGGTATCGGCAAGCTCCGCGAACGGCCCCAGGGCCGCACCTACCGCGACGGCGACCCCTGGCCCGCCATGCAGCGCCCGACCTGGCGCCCCGACATCCGCGCGGCCGTGATCTCGAAGGCGCGGGTCAACATGCACCGCAAGCTCGCCAACATGGTGAAGCTGACCGGCCTGTACCCCCTCGCCGTGCTCTCCGACTGCGTCGTCTACCCGTCCCCGGGCGCCTCGCCGCTGGACTTCCTGCCGTACGCGGCGTCGGGCAAGCCGCTGATGGGCGGCTTCCGCCTCGGCCCCACCCCCGGCCTCGCCAAGCTGGAGGGCGTGCAGCAGTTGGCGTGGGCGGTGGACCTGATGGAGAAGGGTCTGAACCCCGCCCGCCACATCAAGGGCGGCGACGCTGTCCTCGACGACGGCGAATAGCATCGAGCCGTGGCCTCCGCGACCGGAGGCCACGGCTGACAGACCGCTCACCGTGTACGACTCGGACACCTGTCAGGAGCGCTGAACCGCTGTGGGAGAGATCGAGGACGCCATCCTCCGCGCCGACCAGGAGGCTTTCACCAAGGACCCACCCAAGACCCTGAAGGGCCAGATCAACTTCCTGCTCAAGCAGCTTAAGACCACCCGCGCGGTCGCAGCCGAACTCGGCGTCAGCCAGCGGTCCGTCGAGCGCTACCGCAAGGGCGACCGCAAGACCCCGCCCCAGCCTGTCGCCACCCGCATCGAGGCGGCCGTACGCGCCCGCTGGCAGCCCGTCGTACGCGGCCGCCGCCGCAAGGAAGCCGCCACCAGCACCGGCATCACCGTCGAGACCCGCGCCCGCTTCGGCTACACCGCCCCCGTCGGCACCACCGACGACGGCCGCGTACGCCGCCTCACCGTCCACCTCCCGCCCGCCTACGCCCAGCGCCTGTTCGACGCCCGCGCCCGAGGCGCCGACGACCGTGATCTGCGCGGGATCGTCGCCGAGGGCTTGCAGGAGATCTACTTCAAGGACGGCGGCACCCGAGCAGACGAACTCCGAGTCGAGTTCACCGACATCGACTACTTCGACGTCTCCTTCTGACACCCGCCACCAGGCCCGCCCCGGTAGAACCGCACCCGGACCATGAGCACCTGTCCGGGTGCGGCTCACACCCATGTCCGCACGTCAACACCGGGCCTGCCTCGGGAAAAGGGTGCAATGGTGCTGCGGGGAGTTGCTCTCGGACGGGCCGCTCCCGGCCCCCGTGGCGCTGTCGACCGCGGGCAGGAACCCGGCCGCTGTCACACATAGCTGGTCACCGCCCCGGTCGACAGCATCCACCCGGCCCCGGCCCAACGACCGCATTCACGGCCGAGGGTGAACTCAGCTTCCCTGGCTATGCCAGGCGCTTCTTCGGAGCGGGTCGGGCGTCGAGGAGCGCCCACCAGGCGTGGCCGTCGTGGTCGGTATGGGCGCCGCACGCGTCCACGGTGCGCAGCACCGCCACCCCCGCCGGCACGGCTCCCGCCGCGTCCTGCTCACGGGTCTGGTGGTTGAGAGCCATGACGAGAATCTTGTCGTCCTGGTCGGCGAGGTGGACGCTGAGGCGCTTCCCGCCGGCCGCCACGGCCGTGTGGACCAGTCCGTGGACTGTCTTGAGGAAGTCGTGCTCATCCAGCAGCGGGTAGTCCCACGCGGCGACGGCGAGCGCTGCCTGCGCGGCGGCCTTCTTCGCCGCCCAGCGGTCCGCGCGAAACGCGCGGGCGGGTCAACGCGCGCTACCGGCGCTCGGTCAACGCCTGCGGGCACTTCCCGAACGAGACCGCCGCCCTCAAGCAGCTCTACCTCACCACCCTCGCCCTCGACCCCACCGGGAAGAGCCGCAAGCGGTGGACCAGCCGCTGGAAAGAGGCGATGAACGCGTTCGACATCGCCTTCGACGGCCGCCTCTCCGCCGAACGAGTGTGAGCCAACCAGACCAACGAGAAACCTCTACGCCAACCGAGTGGTGAACACCGCTTTCGTGGCTCTGTCTCACTTCCGGTGGTGACGGAAAGGCATGGCAAGAAGGCCTGTTGAGCCGAGCAGGCGCCCGTGTCAGACCCCTGTCCGTGTCAGACCCCTGTCCGTGTCTTCGGCGGGCACAGAGCCAAGGCATCGACCTTCCACTTGGCCTGCGTTAATCGCCGCTAGTAACGATCACCACGCCCCGTTACCACCGGAAGTGAGCCAGAGCCGCTTTCGTGATACTTCCCCCGGCGTCGAACGGACGATCGGACAGAGGAGGGGCCGATGCTCGGTGGGGGCTGACCGATTGGGTAGCGTGTGCGAACTGGGGGCTGTCGAGTCGGGCGCCCTCGGAGAACGGGGGCACTTCATGGGACTGGCCGAGGAGATATCCGCCGTGCGCAGCGTATCGGGGCATTCGGGCCGCTTGCTGGGGGAATTTCGCCGCGCCGCACTGCTGGTGCCGCTGTCGGAGGGTGATGGCGGCGGGCTGATGTCGGGGTGGCAGGGCGGTGTGCGCTGGATTTACGCGTTCACGGACGAGGAGGCTCTGGCCCGTTTCGCGGTGGCGCGCGGTGCTGATGCTGGTGCGCGTGAGTGGGAGTACCTCTCGATCCTGGGGGCCCGTCTCGTCGACGCGGTGATCCCTACGGTCGAGGGTCCGACCGGTGTGGCCGTCGATGTCGCTGATGAAGACGGTTCGATGCTGTTCCCGCCGGTCGTGGGCATCGTTCCGGACGCGTATGCCGTGGATGCAGGGCCCGACCGTGCGGAAGCCGTCTGATGGCCGGCGATGCGGACCTTGAGGTTTCGCCGGCTGCGGTCAAGAACATCCAGGACGGTCTGCGCAGGGCCGTCGCCGAGCTGCGCGAGTCCGGGGATGCGGCCGGCGCCTCGATGGGCGCCGGTTTCAGTGATCTGTCGATGACGGGGATGGAGGCCGGACACGCGGGTCTGGCCACCGACTTCGAGGACTTCTGTGAGCGCTGGGAGTGGGGCGTGCGCAGTCTGGTGCAGAACGCGAGCGCTCTGGCCGGGAACCTGGGGATCGCGGCGGGCACGGTGTGGGAGGAAGAGCACTACATGCAGGGGGCGTTCAAGGTGGTCGCCAATGCCGCGTACGGCAATCCGCATGCGAGTGAGGACGAGATCGAGCAGAAGAGCTGGGACGACATCTGGCGTGCGGATGTCTACAAGCCGGACTACAGCGATGAGTCCTTCGAGAAGAGCGACGCGGACATCAAGCAGACCTGGTCGGACACGGGCGACAAGCTGACTTCCAGCGGGAAGATCGGATCGCTGAAGGATCTGCTGGACCAGGCCGGCGGGGGCGGTAACTGATGGGCTGGAGGGACTTCGTACCGGACTCGGCGGAAGACTGGGTCGAGGACCGGGCCGAGGACCTCGGCGACGCGGTCGAGTGGGGCGGTGACAAGGTCGCCGGCGCGGCAGAGAAGGTGGGCCTGGACGAGGCGGGCGACTGGGTCCGTGACAAGAGCCGATCGGCCGCCAACCAGCTCGGCTCGGACGTCTCCGAGCTGGAGCTCGGACAGACCGAGGACCCGAACAAGCTGGTCTACGGCAGCGTGTCGAAGATCCGCGCGCAGGTCTCGCACCTCAGTGACTTCGAGCTCTCGTTCACACTCGTTGGCAACGGCCTGAAGGCCCTGGAAGGCGACGGCCTGAAGGGCGCGTCGGCGAACGCGTTCCGGGACGCGATAGCCAAGGAGCCGCCGCGCTGGTTCAAGGCGGCCGAGGCCTTCGGCAAGGCCGCCGACGCGATCAACCGGTTCGCGGACACCGTGGAGTGGGCACAGGGCCAGGCCAAGGAGGCCCTGGAGGAGTACAACAGGGCCAAGAAGGTCTCTCAGGACGCGCGCACCGCCTACAACAAGTCGATCATCGACTACAAGGCGGCGGTGAAGGCCGAGAAGGACACGCTGCCGCCGCGGCCGGCCGACGACTTCACCGACCCCGCCGATCCGCTGTTCAAGGCGGCCGACGACAAGCTCCAGACCGCGCGCACCCAGCGCAACGAGGTCGCGGAGACGGCCCGTACGGCGGTCCGCGCGGCCCGCGACGCCGCCCCGCCCAAGCCCTCGTACGCCGAACAGCTCAAAGACGGCATGGACTACCTGGAGATCGCGGAAACCCACCTGGCCGGGGGCGTCCTCAAGGGAACGGCGGGCCTCGCCAACTTCGTCCGGGCAGTCACCCCGTTCGACCCGTACAACCTCACCCACCCCGCCGAGTACCGGACCAACCTCAACTCGACGGTCGCCGGCCTGCTCGTGGCGGTCAACGACCCCATAGGCACGGGCAAGCAGATGCTCGACGACTTCATGAAGGACCCCACCGAAGGCGTCGGCAAATTCCTCCCGGAACTCGCCGGCACCAAGGGCCTCGGCGCCGGGAAGAAGGCCGGCACGGCCGCGAAGCACCTGGACGACCTGGACGGCCCGGGCGGCAAGGAGACGGACGGCCCGGGCCGCAAGGAGACGGACGGGAAAGGACCGCACCACGGCGAGCGGCCCGACCCGGACAAGGCCAGTGAGGGCACCGACCCCGTCGACCTCGCCACCGGCCGGATGTACCTCCCGCAGACGGACGTGGTCCTGCCCGGCACGTTCCCGTTCGCGTTCACGCGCCGTGCGGAGTCCGGCTACCGGGCGGGCCGCTGGTTCGGCCCCACCTGGTCCTCCACGATCGACCAGCACTTGGAGATCGACGCCAAGGGCGTCGTCCTGGTCTCCGAGGACGGCCTCCTCGTCGGCTATCCGCATCCCGCGCCCGGTGTGCCCGTACTGCCGGTGTCGGCCTCGGCCCCGCGCCACCCGCTGGCACGCACCCCTGACGGCGACTGGACGCTGACGGACCCGCTGACGGGTGCCGTCCGCCGCTTCGTCCCGCCGGCCGACGGCGCCGAGAACGGCATCGCGCCGATCGCCCAGTTCGAGGATCCGAACGGCAACCACGTCGTCTTCGAGTACGACGAGCACGGCACGCCGCTGGGGCTCACCCACTCGGGCGGCTACCGGCTGCACTTCGAGACCGAAGGCGGCCGGATTACGGCCCTGCACCTGTCCGGCGGCGGCCGCGTCCTCGCGTACGGCTACACCGACGGGAACCTGACCGAGGTCACCAACTCCTCCGGTCTGCCTCTGCGGTTCGCCTACGACGACCGCGCCCGCATCACCTCCTGGACGGATACGAACGAGCGCCGCTATGAGTACGCCTACGACGACCTCGACCGGTGTGTCGCCGAGGCCGGCGAGGCGGGCCACATCGCCCTCACCTTCCGCTACGACGACGTGGACCCGCAGACCCGCCACCGGGTGACGCGTGTGACCACCGCCGCAGGTCATACCCGCCAGTACCTGATCGACGACCGGTACCGGGTGGTGGCCGAGACCGACCCGCTCGGCGCGGTCACCCGGTACCAGTACGACAGCGGCGGCCGGCGGACCGCGCTCACCGATCCGCTCGGCCACACCACCCGCAGCACCTTCGACGACACGGGCCGCATGGTCTCCTACGTCCGGCCCGACGGCAGGGAGGCCCGCGCCGAGTACAACGACCTCGGCCGGCCGGTCAAGGTCGTCGCCGTGGACGGATCGGTCGTCCACCAGACCTACGACGAGCGCGGAAACCGCACCGCGGTCAGCCGCCCCGACGGGACGGTCACCCACTTCGGCTACGACGAGAGCGGCCACCTCACCACCGTCACCGACCCCCGCGGGGCGGTCACGCGGATCCGCACCGACCGGGCCGGGCTGCCGCTCGCCGTCACCGACCGGCTCGGCGCCACCACCACGTACGAGCGGGACGCCTTCGGGCGGGTCACGGCGGTCACCGACCCCCTGGGAGCGGTCACCCGCATGGAATGGACGGTGGAGGGCAAGCCGCTGCACCGGACGGACCCGGACGGCCGGCGCCGCTCGTGGACGTATGACGGCGAGGGGAACTGCCTGACCCGTACGGACGGCCCCGACGGCGGCGGGGTGCACTTCGAGTACACCCACTTCGACCTGCTCGCCGCCCGGACCGACGCGGACGGCACGCGCCACGCATACACATACGACGCCGAGCTGCGGCTGACCGGGGTCCGCAACCCGCAGGGCATGACCTGGGAGTACACCTACGACCCGGCGGGCCGGCTCATCCGGGAGACCGACTTCGACGGCCGTGTGCTCGACTACGCCTACGACCCGGCGGGCCGGCTCGTCACCCGCACCGACGCCCTCGGGCAGCGGATCACGTACGAGCGCGACGCCTTGGGGCGCACCGTCCGCAAGGACGCGGGCGGCACGGTGACGACGTACGAGTACGACGTCTTCGACCGGCTCGCCGTCGCGGTGTGCGGGGACAGCGTGCTGACCCGGCTGCGGGACCGGGCGGGCCGCATCCTCCAGGAGACGGTCGACGGCCGCACCCTCACCTACACCTACGACGCCATGGGGCGCCGCACCGGCCGAACCACCCCCACGGGCGCCGTCGCCGCCTGGGCGTACGACGCCGCAGGCCGCTACGACGCCCTGACCACGTCCGGCCGCCGGATCGGCTTCACGCACGACGCGGCGGGCCAGGAGCTCAGCCGTACCTACGGCGACGCCGTCGCCCTCGACCAGGCGTGGGACGAGACCGGCCGGCTGGTGGAGCAGCGGCTCACGGGCGCAGGACAGGGGGTGGTGCAGCGCCGCGGCTACACCTACCGGTCCGACGGGGTCCTGACCGGCGTCGACGATCTGTTGGCCGGCCCGCGCAGCTTCGACCTCGACCCGCGCGGCCGGGTGACGGCGGTGCACGCCGGTAACTGGACCGAGCGCTACGCCTACGACGACGTGGGCAACCAGACCTCCGCGTACTGGCCCGGCGCCCATCCCGGAGGCGGGGAAGCCACCGGACCGCGCACCTACGAGGGCACCCGGCTGATCGGCGCGGGCCGGGTCCGCCACGAGTACGACGTCCTCGGCCGGGTCGTGCTCCGCCAGAAGGCCCGGCTCTCGCGCAAGCCCGACACCTGGCGCTACGAGTGGGACGCCGAGGACCGAATTACGGCCGTCACCACCCCGGACGGGACGCGCTGGCGGTACACGTACGACCCGCTGGGACGGCGGACGGCGAAGGAACGGATGACGCCCGACGGCCTGGAGGTGGCCGAGCGCACGGTCTTCACCTGGGACGGCACCGTGCTGTGCGAGCAGCGGACCGCCGCCGCGGCGCAGGAGGCCGGCGGGATCGCCGTGACCTGGGACCACCGCGGCCTGCAGCCGCTCGCGCAGACGGAGCGGATCCTGGGCGCCAGCCAGGAGGTGGTGGACGAGCGGTTCTACGCCATCGTCACCGACCTGGTGGGCGCACCCGCCGAACTCGTCGACGAGCGCGGCGGACTGGCCTGGCGCAGCCGCTCCACACTGTGGGGATCCACGGCCTGGAACCGGGACGCCACGGCCTACACGCCGCTGCGCTTCCCCGGCCAGTACTTTGACGCCGAATCAGGCCTGCACCACAACTACTTCCGCACGTACGACCCCGAGACCGCCCGCTACCTGAGCCCGGACCCGCTGGGCCTGGCGGCGGCCCCCAACCCGGTGGCGTACGTCGCCAACCCCCACGGGTGGTGCGACCCCTTCGGGCTGGCCCCGTACTCGGACAGCACCCGGGCGGCGCAGGGCGTCGACCACCAGCTCAACGAGGCGGAGAGCGGCAAGGACAACCACTACCTGCAGGGCATCGGGAAAGACGAGGTGAAACTGGAGAAGTACCTGCGGGGCCATCTGCAATCGCCGGCCAACTACGTCGACAGCGACACGGGGGCGCGGATCATCATCGACAAGACCCTGGACCCGTCCAGGCCGGTGGCCATCATCCGCCAGGACCATATGATCCACGCGTACCACATCGAGCCGGAGGACCTCTCCAACTACATCACTCCGCGGGACGGCAAGGACACCGCGAAGTGGCGGACCCCGAAGGGGGACGAAGTGAATGAGTAGCCGCAGCGGTATCCCCCGCGATCCTGCACCCGGCTGGCCGGGCTACCACGCCGAGCCGTCCTACGACCCCGGCCAGAGCCGGGTCTTCCCGGCCCCGCTGCCGGCGGAGCTGCGGGCGCTCGGCAACGACGTCCGGGCGGCCGACTGGCCGGTGCGGCTCGCCTTCCGCAACTCCCGGACCGAGCTGCTCGACACGCTCTGCCGCTGGCAGACCCTGCGCGCGCTGGCGTACGTGCACCTGCTGGCCGCCCGCACGGGGGACGAGCGGCTGCCGGCCGACCTGAGGGTGGTTCCCGACCCGGAGGCGGTCGGCGAGCCGGGCCTGCCCGCGCTGCTGGCGAGGCTGGAGCATGCCGCCGCCGGCCTCCCGGCGGACCTGCTGGACGCGGTCGTCTGCGACAGCGGCGGGCTGCTCGCCGACAATCGGTTCGCGGCATCGGTGCTGGCCGCCGGGCTCACCGCCGATTCCCGGCCGGGGGACCCGGACAAGGCGGTCTCCCGCGCCGTGGTGCTCACCAGCTACTGGTACGAGGTCCCCGGGCTGCGCGGCGCGCTGGCCCTGGCGTGGAGCGCGAACCTGTTTGTCCGCTCCTGGCTGGGGTGGTCCCAGCGGTTCGTGTACGGCGACCCGGCGGGAGGCCTCGGCATCACCTCCGACCCCCGCCCGCCCCGCCCGGCGGCGTCCGCCCTCCCGAAGTGGGCGGAGCCCCTGCTGGACCGCATCGAGCAGGGTCCGGGGGCAGCCTCGTGACCTGGGCCGACTTCGTCGTGACCTCCCGGTACTCGTCGGCGACCGCTAGAAGTTCTTCGGCCGTCCGCCCGGGAGCGTCTCGCCACCACGGCGCCACGAGGCACAGCCGCACCAGCTCCGGCAGCCCGAGTGCGAGTGGGCCAGGCTCGTCGTGTACGGCGCGAAGGGCTTGTCGTTAAGATGCCGGCAGATCAACGTCTGGACCCGAGGCAGGGTCCAGCGTTCGTCTTCATAGCTGTGCCGTGCGCCGACGGGCCCTTGCCGAGTTCCTCCTCGAGCACGGCGAACTGTTCGTCGGTGATGGTCGGGGCGTTCGCCGGACCCGCTGACCGCAAGCCCTCCATGCCGTCCTCGCGCCAGGCGACCGGACAGGATTGGCAACCCCGCATGAACGCTGCCGATCAAGCTAGGGTCCGGGTAGCCCGTGCCGATATGGCGTGCTCGGGTGAGCCCGGGGCCCAGAGCGCTCTGGGGGCAGCAGTACCCCCGGGCCGCCCCCACCCCTACTGCCGCCCGTGTTGCTGGTGTCCGGCGTGACCCGGCGGCGTTGGGCAGGGCATGGAGATGGTGGAGCGGTTGCCGTTCGGGATGCGGACCGCGGTCGAGGCGACGTACGTCCGGTGCGCCCTGTGCGGCGCGTTCGGTGAGCTGGTCCTGGACAGCGGACGGCTGGACGAGGCGCTGGCCCGCGCCCGAGATCACGTCCGCGAGACGCATCCGGGCGCGGACATCCCCGAGGCGCTCCGGCTCGTGCCCGATGTCGCCTTCCCGCCGGACGGCTGCCGCGACGTTGTCGAGTGGGTCGAGCAGTACAACGCCCGGAACACGCTGCCGGTCCCTGGCCCGCGATAGCTGCGCCGGCTGGCGCCGCCGTCGGCCGCTCAGGCGGCTGGAGCGGGCGTGTGCTGTGGGATTCCGTGGGGCGGGGCCCCGCCGGTGCTGTTGCCGGGAAGAGGTGGGTGGCCGGGCCCTTGTTCCGGGAGCCGCGGCGGGTGCTGTACGGCTCCCTGGTGGGCGTCTGTCCGGCCGTGGACGAGGTAAACCGGGGCCGCGCTGCGGGCGCAGACGGGATGGGCTCAGGTGTGGACGCGGCTGTTGGTGCCGTCGTGGTGGTCGGCGTTTTCGTCGTCGAACTAGACGAGTAAGTCCGAAGTGTTGGTCAGTGGTCGTAGGCGACGAGTGATCGGGTGATGGATGTTCCGTTGGCCCGGTTGTGCCAGATGGCTGCGGTCAGGGCCAGGATGCGTTGTCCGACGCGGGCCAGGACCCCAGATGGGGTTCTGGCTCCGTGACGTTCGAGGTCGAGTTGGCCTTTGAGGGTGTCGTTCACCGACTCGATGAGCTGCCGGATCGGTTTGAGCAGGTGCTCGCCCGGCCGTGGCTTGCGGTTGCGGTAGCTGGGCCGCAGCAGGGTCAGGCCGTGGTCGGCCATGAAGGCGTCCAGGTGCTTGGAGACGTAGCCCTTGTCGCCGACGATGGTCTGCCCGGGGTGGGTGGCCAGCAGGTCGATGTCCTGGGTGAGCATGCCGGCGAGGACTTCACGCTCGTCCGTTGTCGGGTTGGCCAGCGCCCAGGCAATGGGCAGGCCGCCGGGTGTGCAGAGCAGGTGCAGACGCAAGCCCCAGAAGAACCGTGAGTGCGAGGCGCAGTAGCCGTAACCGGCCCAGCCCGCCAGTTGCGAGCGTTTGACCGTCGGCCGTGAGCGGGCGCACTCCACGGGGGTGGAGTCCACGATCCATACGTCGTCGTGCCACAGGTCGGTGTCGCGGGCCAGAGTGCGGATGAACCGGCTGATCAGCGTGTTGGCGGCCCGCAGGCGCTTGTTGTAGCCGGACTGCTCGGGCAGGTAGGGGAAAGTCGGCGCTCAGGTGGCGGCGGGCGAACCGAAGCCAGCGGGTCTCGGAGGCGAAGCCGAGGACGGCCTGCATGACCGCGAGCGTCAACAGCTCGGCATCCGTCAGCCTCGGCGGACGGCCCCATCGCCGCGTTCCTGCCAGAGAGTCATCAATCCTCACGTACAGTGCAGTCGCGAGGGTTTCGAGATCTGTCGTCACAAACGGATCAACGAGACCCTCGCTTCATGCGCCCGAAGACTTCGGACTTACTCGTCTAGAGCATGGCTCCCGGCCGTCCACCTGCTGCCCCGCCCAGGCCGCCGGGACGGACTTGCATCCGGAGTTCGACCGGGCCGACGTCGTCAACTGGCTGCTCGCCCACGACAAGATCACCCTTCCCGCCGGTGCGGGGCAGGCGTCGCTGCTGGTGCGCGGCGAGAGGGGCGCTACAGGCAGGTTCCGGCTGGATGCCCCGTGGCTGGGCCTCGCCGACGACATCGAGGGCACCGACCGGCTGTCGGGCTGGGTCGCCGACGACGCGGACGCCGACGCGCTGGCCGCCCTCGCGGCGGGCCCGGTCGGGGCCACCCTGACACGGCTCACCGCACCGGGCGCGGGTCCCCTCGCGGTGCTCGGGGACGTCCGGGTGACCGACCGGCTTTGGTCCGGATCTGGGGGCCTGCGAATCACGCTGGAATGGCCGGCCCGCCTGCGCGGCACCACCGCGCACACCGGTAACGGTGGTGTGGTCGCCACGGCGTCCCGCAGACCAGGACCGGCGAGGACTGCGTGTGCACCCGCCACGACTGCGGCGGCCTGGACCCAGTCCTGTGGTGCGACGAACACGGCGGCGAGGCGCCCCCCAGTGCTGGACTGGCACGCGGGCGGCGGCCTGCGCTGCGCACAGCTCGGGCGAGGAAGCGTGGCAAGCGTGACAAGCGCGTAGGGGCTCGTCGGCTGAGGGTGGTCCCGGCGCAGCCTCGGATGCGCCGGGGGCCGGTCAGGCCCGGATTTCACCGTCAGGGTTGCCGGCGGCGCGTTGGTACCAGGTTTCTGCCTCGGCCGCCCGCCCTGTGTTCTGCAGCAGCCGTGCGAGGTTGTTCATGGCAGGGGCGTTTCCGGCTTCGGCGGCGCGCCGGTACCAGGTTTCTGCTTCGGCCGTGCGCCCGGTGCCCTGCAGCACCACTCCGAGGTTGTTCATGGCTTCGGTGTTTCCGGCGTCGGCGGCGCGCTGGTACCAGGGTTCCGCCTCGGTCTCGCGGCCAGTGGTCTGCAGCAGCACCCCGAGGTTGTTCATGGCCTTGATCTGTCCGGCGTCGGTGGCTTTTCGGTACCAGGTTTCTGCCTCGTTGGTGCGGCCGGTGTTCTCCAGCAGCAGTCCGAGGTTGGTCATGGCGCCGGTGTTCCCGGCGTCGGTGGCTTTTCGGTACCAGGTTTCTGCCTCGTTGGTGCGGCCGGCGTCCTCCAGCACCATGCCGAGGTTGTTCATTGCGTTGGTGTTTCCGGCGTCGACGGCGCGCTGGTACCAGGGTTCCGCCTCGGTCTCGCGGCCAGTGTTCTCCAGCAGGAGTGCGAGGTTGTTCATTGCGTTGGTGTTTCCGGCGTCGACGGCGCGCCGGTACCAGGGTTCCGCCTCGGTCTCGCGGCCAGTGTTATGCAGCAGCAGTGCGAGATTGTTCATAGCGTTGGTGTGTCCGGCTTCGGCGGCGCGCTGGAACCAGGGTTGCGCCTCGGTCTCGCGGCCAGTGTTATGCAGCAGCGCTCCGAGGTCGTTCATGGCGTCGGTGTTTCCGGCGTCGATGGCTTTCCGGTACCAGGTTTCTGCTTCGTCGGTGCGGCCGGTGTTGGCCAGCAGCACTCCGAGGCCGTGCATGGCGTCGGTGTTTCCGGCGTCGGTGGCTTTGCGGTACCAGGTTTCTGCCTCGTTGGTGCGGCCGGTGCCGGCCAGCACCACTCCGAGGTTGGCCGTAGCGTTCATCTGTCCGGCGTCGGCGGCCTTCCGGTACCAGGTTTCCGCCTCGTCGGTGCGGCCGGAGTAGGCCAGCACCACTCCGAGGTTGGTCATGGCGTCGGTGTGCCCGGTGTCGGCGGCTTTCCGGTACCAGGTTTCTGCCTCGTCGGTGCGGCCGGTGCCGGCCAGCACCACTCCGAGGCTGTACATGGCGTCGGTGTCTCCGGTGTCGGCGGCTTTCCGGTACCAGGTTTCTGCCTCGTCGGTGCGGCCGGTGTTCTCCAGCAGCAGTCCGAGGTTGTTCATGGCGTCGGTGTTTCCGGCGTCGGCGGCTTTCCGGTACCAGGTTTCCGCCTCGTCGGTGCGGCCGGTGTTCTCCAGCAGCACGCCGAGGTTGTTCCTGGCGTCGATCTGTCCGGCGTCGGCGGCTTTTCGGTACCAGGTTTCTGCTTCGTTGGTGCGGCCGGTGTTCTCCAGCAGCACGCCGAGGTTGTTCATGGCGTCGATCTGTCCGGCGTCGGCGGCCTTCCGGTACCAGGTTTCTGCCTCGTCGATGCGGTCAGCCTCTTGCAGCAGCCACGCGAGGCTGTACATGGCGTCGGAGTCTCCGGCTTCGGCGTCCCGTTGGAGGAGCTGCTCGTCGGTTTCCGACGCCTCCGCTGCCGGCACGGGGGTGGGCCCGGGTGCGAGGTGGGCGGTGCGCAGGCGTGCGGCGACGTCTTTGGCGGTGGGGGGACGGCCGGCGGGGTCTTTGGCAATAAGGGAGGTGATGAGGTTGTCGATGTCGGGCGGGATTGCGGGCTGGCGGGTGCTGGGCGGTTCGGGAGTGGTGGACAGATGCATGGCGATGATGGCGTACGCGGAGTCCGCGGTGAACAGGGGGCGCCCGGTGAGGAGCTCGTAGAGGCTGGCACCCAGGGCATACAGGTCGGCCGAGTGCGTCGGTGTCTGGCCTCTGAGCTGCTCGGGAGCCATGTAGTGAGGGCTGCCGAGCAGCGCTCCGGTCATGGTCAGGCCGATCGTGCCGTCCTGGACCTGGGCGATCCCGAAGTCGCAGATCTTTACGGTGCCGTCGTCGAGCAGCATGAGGTTGGCCGGCTTGATGTCGCGGTGGACGATGTTTTGCGTGTGGGCGGCGGCCAGCCCGTCGCACACCTGGGCGCCGTACTCCACCACCTGCTCCAGCGGGAGCCCGCCGGGGTGGTCCTCGCGCAGGACCGTCGCGAGATCACGACCTTCCAGGAACTCCATGACGAGGAACGGAGAGACTTCCACCTGCCCGTCGGCGCTCGTCTCCCGGTGCTCGCCCAGGTCGTGGACGACGGCGATGTTGCGGTGGTTCAGCCGGGCGGCTGCTTCGCCCTCACGGCGGAAACGGGCCAGGACCTGGGCAGCGAGCCGTTCGTCACGCAGATGGGAGATGAGTACCGTCTTGACCGCGACGGTACGGCGCAGCCTCAGATCGGACGCCGCCCATACCTCGCCCATGCCGCCGTGCCCCAACCGGCTCTCGAGCCGGTAGCGGCCCGCTAGCTCCATCCCCCTATACATGCAGGTCAACGTATGCGACTCGCCCGCGATACGACAAGAATCCTCCGAACCTGGGCGGGGTTTTCCGGCCGCATCCGCCGGCCCGCTGCCAGGAGTACGAGCACCGCCGCGACACCGAGACCCCGCATGCAGCAGCTCGGCGAACATCACGGCACCGACACCGTCGCCCAGCACCTGAACCGCCTCACCACCGCCACCTCCTGGCAGGAAGCCACCGGCAGCGCCCTGGTCGGCCGCCTCGTCGACGCCACCCTCACCTCCCTGACCACCCCGCCCGGCGCACCGGCCCCCTCCCGGCCCCGGGTGTCCGCGGCCGCCGCCCGCTCCCGCTCCACCACCACCCCCACTGCCGCCGCGGCCCCCGGCCGGCCGGCCCCGGCGGAGGCCGCGGTCCCCACCCACCGGCAGCAGGCCGCACCCGTCAGGGGCGCGGGGCGTAGGCGGTGATGGTGATGACGGGCAGGCAGCGCCGGGCCGGTGGCAGCGCGCTGGCGGGTCTCGTGCTGGCCACGGCCGGCTGGTGGGCGCAGTGGTCCGGGTACGAGGTCGTGGGCACGGCCCTGACCCTGCTGGCCGGGACCGTGGTGCTGGCAGGTGCGTGGCGCTCGGGCGTCCTGCACCTCCCGCAGCACGAGGCCGGCCGCCAGGCAACGCAGCAGCAGCGGGCGCGGGACTCTGGCTGCAGATGCTCGGAGGGCTCCTCCTCATGCGCACCCTGCTCCGTGCTCTACGGGCCCCTCCACTTGCTGGCAACGCTGCTGTGAGCGCCGCCCGCGCCGCGCACGCGTTCCGGCTGTGGGTCTTCCGGGCCATGGCTCGTCCCTGCTCCATCACGCCCGCCGCTGCGGTCCCCGGTCAGCCGGCCCCGGCCGAGGCCTCGGTCCCGGCCCACCGGCCGCGCCTGCCAGGGGCGCGGGAGTTCGGTCACGGGAGGGGACGAACATGAGGTTCTTCTCCGTGAAGGGCCGGGAGTACGTTGCCCTCACAGTGCTCGGGAGCGACGACTTCGACGCTCTGGAAGTGGTGGAGATGACTGCTGCCGGGCGTGGCGCCCTCTTGTTGGAGTTCCGGATGGACGAGGAGACGGCCACGCTGGTGCACCTTGGCGCGGAGGTGGGTATTCCGCTGCTCAGGGCCTCCCTGGAGATCTTCCGCACGGACTTTCTAGAGCCGAGGCGCGCGGCGGGGTTGCCGCTGCGGCCCTGGTAGCCGAGCCTGGTCTGCGCCTTGGGTTTCGGTTGCCGGAGGGAGGGTGTGGTCGCGGTGTGACGACGGCCTGAGGCTGATGCCGGGGCGGACTGGCCGGCCATGCTCCGGTAGCGCTAGCGCGAGGAGTAACGCTCGGTGGGGGGTTTGTTGGTGTGTCGGGTCGTTGGTGGCCTGGGGTGTTGTGGGTTCGTTGAGAGGTGGATTTGGCGGTTCGGCGGGGTGGCTGGGGTGTGTGAGCTGGGGTTATGTGTTTCGTGTTGAGGGCGGCAGGGTTCGTTGTAAGTAGTTCTGGCGTGTAAAGGCCCGGTTGGTGTTTGTGCTGGTCAGGGCTGTTCTGCCTGTCTGTTTGGTAGGTGGGGTTTATCGGCGTCGGTGGGGGCGGTGGTGGGTTTCGGCGAGGTGGTCGAGTCGTACCGCGTCGAGGGCGGTTTTGGTGATGCGTTCGGTGCCGTCGCAGATGGCGGTGATGGCGGCTTGGCGGATGAGTCGGGTGAGGGATCCGATGCGGCCGGCGGTGCGCTGGTGGAGGTAGGGGGCGTGGGCCGGGAGGGTGCCGGCTTTGTGCTGCTGGAGGTCGAGGTTGTTTTCGATGTCGGTGATGGCGTCGCGGAAGGGTTGGCGGGTGCCGTGGCGGGCGGGGAGGGGGCCGCAGTCGACGAGGGTGGCGCGTCCGGCGAGTTGAGCGCCCCGTGTCCCGCTGAAGAGGGGTGTGTCGGTGACGTTGATGCCGGCGTAGACGAACGTCGCGGGGAGGCGTTCGCTGAGGTCTTTGAGCAGGTCGGCGGTTTGGGCGCCGGTGGTGGTGCGGGGGTTGAGGCGGTGGATCTCGTCGATCATCACCAGCTGGACGCCGGCTTGGGTGTAGGTGTGGCAGACGGCATCGGTGATCTGGGTCTGGGTCATACGCGCGGTGACGGGGATGCCGAGGTAGCGGGCGAACTCGGTGACGAGGGTTTTCGCGGTCGCGCCGGGCGGGACCAGGACATACGCGACGGGTACCGCGGTGTGGGCTGATCCGGGTGGTGCGGGGTTTTTGCGGGTGTGGGCGAGGTGGCAGGTGCGGCCGACGTTGAGGAGGGCGGTGGTTTTCCCGGCTGCGGCGGGTCCGGTGACGATCAGTGAGGGCCGTGCGGTGTTCTGCTGGTGGCGGCCGAGGATCATCAGGGTGCGGACCTGGGTGGTCAGGGTGTGGATGGCGGGGGTGCGGATGGTGACGAAGCTGGAGTGGTAGGCGAGGCGTTCCTCTGTACTGCGGGGCGGATCGCCGGGCTGGGGCGGTGCGACGGGGTCGGTGGTGGCGAAGCGCTGCCAGCCTTGCCAGGTGGTCAGCGGCCAGGATGGCTCGGCCGCACCACTGCCGCTGGTGCCGACTGGTGTGCGGCTCAGGTTCGGCGTCGTGGGGTGGGGGGTGTTCACCACTTGTCGGCTTCCTCGTGCGCGTTGTAGAGCCCGAGTCCGGTGGCCGGGGCGGGGCTGACGTCGTCGGGCAGGTCGTCGAGGCCGTCGAGGTCGTCGAGGTCGTCGATGGTGTCGTCGTCCCGCTGTTCCGGGCTGTCGGCGGGTGCTTCGGTGCCGTGGGCCCCATTGCGGGCTGTGGGGAGTGGGACGTGAGCGGTGCGGGCCAGGAGGGTTTGTTCGGTCTTGGTGGCGTGGCCGCTGTGGACGCGGCGCATGAGCTGGTCGAGGGCGTCGGCGAGGCGGGCTTCGTGCTGCTCGGCGTCACCGTGGTTGCAGTCAGTGGCCTGGGTGCGGATGTGCTGCCAGGTGTGTTCGTCGAACGGCCGGTGGACGTGGTCGCGGTGGATCCACGGAATCTCGGTGAGTTCGCCGTCGGGGAGCCGGATCCAGATCTGGCGGACGTCGTGGGGGTTGTAGTGGATCTCCCATTTCCCGCCGCGGCCGGCGACGGGGGAGGCCTGGCCGCGGTGCGGGGCGAGGAGATCTGCGTCGTAGGTGCGGTGGCGGATGGTGATGCCGGCGGGGGTGATGGCCTGCCAGCGCACGGGCAGCAGTTCGAGGTAGTCGCGCCCGGTCAACGGGACGGGCACGTATCCGGCGACGGCGACGAGCGCGCCCCACATCTCATTCGGGGTGAGCGCCTTCCTGGGCATCATCGGGTGGCGCAGCCCTTCATGGGGCCGGTGGTGGTAGTGCACCAGCCACTCATCAAGCAGGTCCTGCAGCTGGGCGACGCTGAAGCAGGCGTCTTTCTCGGCCTCGGGGCCACGGCGGGTGACGTCGGATCCGGTGTAGCCGGGCAGGTGCTGGCAGAACAGGGCGTTGATAGAGCCGAAGGTGCGCTCGACGATGCCCTTCGCGGTGGGGGCGCGGGGCGGGGCGGGCTGGACGCTGATGCCGAGGGTCTCGCAGGCGGCGGTGAACGCGGCGGAGACGAAGACCTTGCCCCGGTCGACGACGATCGTCTCCGGCAGGACGACCGGCCGGGCCGCCGCGCCGGCCAGGCGCTCATCCAGCGTGGCCAGCTGCTGGTAGGGGAGCGCGCGGGCGTGGTCCATGCGCAGGATGTCCGGCCAGGTCGGTCTGGCCGGGTGCGGGACGGCCATCTCCGCCAGCAGCAGGGCCGCGTCCACGGACTTGGTCGCGCTGGGGCACAGCACGGCGGCGAGGATGGCGCGGGTGGCGACGTCGACGGCGATGGTGAGCTCGGGGCGGGCGAGGCGCCCGTCGTCGAAGAGGGCCAGGACATCCAGGCGGGTGGTGTCGATCTGGACCTGCTCGCCGGGCCGCAGCGCGGTGGCGGGGGTGAAGGCCCGCCCCTCGACGCTCGCGGGCACCTGCCGCACCGGGCCACTGGGCAGTTCACCGGGGCGGGCGAGGGAGGTGACGAGCCGGTACAGCGTGGCCTGGGACGGCACGGGCACCGCACCGGGGCCGTGCCGGTCCTGAAGGATCTGGTGGATCAGCGGGAACAGGCCGTTGATGGTGCCCCTGGAACGCCCGCGCCGGCGGCGCAGCGCCTCACGCACGGCTGCGACGACCCGTTCGTCGGAGCGCCCGGTAGAGCTGGAGGCGCGGGTGGTGCGGTGGTCGAGCAACCCCCACAGTCCCTGCTTGCGGTAGGCCAGGCGCATGCGCTGCACCGTGGTACGTGACACCCGCCCGAAACCGAGGGCGGTCAGTTCCTCGGCCTTGGCCTGCTCCCGTTCGGCCAGCGTGTGTCGTGCGGGGTCGTACTGCTCCCGCACCACTCCACCGCTGCCGGGCCCGTCGGCAAGGCCGCACTCGACTTCCCGGACATGCCGCTGCCAGGCCAGGGCCTTCTCCCGCGCCGCGGCGGGCGCGGTCTCGAACAGCCCCCACTGCGGGGCCGCCTGCGGCACCTCCGCCCCGATGACACTGAAGCCGGGATCGGCGAACAGGTACCCGGCAAGCACCGCCTCACCGCCGCCGTCCGGGCCGACGAGGTGAACCATCTGTCCGGACAGAGCGACCACCTGCCACTTCACACCGCGGAAACGGACATGCGCCCCGACCGCCACGGCCGGCCGGGCAGTGCGCCGCGCGCTCACCCGGCACCTCCCGTCCGGCCCAGACCGTTCCAGTCCCTGGGGCCGACGGGGACGCACTCGTGCAGCGGCGCCTCCAGGTCCGTCGTGAGCTGCCCGTGCCACAGGGCGTGGAAGACGACGGGAAGGACCTCGATCGGGTCACCGACAGCTTCGGCTCCCTCGATCAGCGGCCGCGGTCGCGCGAACGCTTCCACAGCCGCGGGCGTCAGGCCCGGGCGGCCGGCGTTGCGGGGATGGCGATAGCCGGCCAGCCACTTCAGATTGGAGGCCGGCACATCGTCGAGCGGTGAAAGGCGCCGGTAGGCCCAGCCGATGTCCCCGCACGCCCTGGCCACCGCGTGCGCGGCGCCCAGGGCACGTTCGCCACCGGCGTCGGGGTGGCTGGGGCAGTCGGCCAGCAGGCCCGTGCCGTCGCGGTAGCGGGCGAACAGCTGCGGCACCCAGGAACGCACCCGTCCCCGTTCGTCGCGCCACAGCAGCCGTACCGGCCGCCCGGCGAGCCCGGTCACGCGTGGGTCGCGGTCCAGGGCCATCAGTTGGGTGCGCATTGCGTTCGACCCCGCGGCCACGTGCCGTCCGGTGGTCGCCGACCACCACAGTCCCGGCCCCCAACGCCGCCCCGGCACCACCGGGAACGCCGACACCGGCGGCAACTCCTCGAACGCCACCGTCATGGCTGCATCCGCCCACCGCTGCTGCACCGACTGCCCCACCGGGTCGAGGAACACCGCCTCGAACCCGCTCCCACTGTCCAC

Protein sequences of DBSCAN-SWA_4

>NZ_CP018870|7505840:7577592|7569596_7572035_-|WP_159393482.1|DBSCAN-SWA
MGEVWAASDLRLRRTVAVKTVLISHLRDERLAAQVLARFRREGEAAARLNHRNIAVVHDLGEHRETSADGQVEVSPFLVMEFLEGRDLATVLREDHPGGLPLEQVVEYGAQVCDGLAAAHTQNIVHRDIKPANLMLLDDGTVKICDFGIAQVQDGTIGLTMTGALLGSPHYMAPEQLRGQTPTHSADLYALGASLYELLTGRPLFTADSAYAIIAMHLSTTPEPPSTRQPAIPPDIDNLITSLIAKDPAGRPPTAKDVAARLRTAHLAPGPTPVPAAEASETDEQLLQRDAEAGDSDAMYSLAWLLQEADRIDEAETWYRKAADAGQIDAMNNLGVLLENTGRTNEAETWYRKAADAGQIDARNNLGVLLENTGRTDEAETWYRKAADAGNTDAMNNLGLLLENTGRTDEAETWYRKAADTGDTDAMYSLGVVLAGTGRTDEAETWYRKAADTGHTDAMTNLGVVLAYSGRTDEAETWYRKAADAGQMNATANLGVVLAGTGRTNEAETWYRKATDAGNTDAMHGLGVLLANTGRTDEAETWYRKAIDAGNTDAMNDLGALLHNTGRETEAQPWFQRAAEAGHTNAMNNLALLLHNTGRETEAEPWYRRAVDAGNTNAMNNLALLLENTGRETEAEPWYQRAVDAGNTNAMNNLGMVLEDAGRTNEAETWYRKATDAGNTGAMTNLGLLLENTGRTNEAETWYRKATDAGQIKAMNNLGVLLQTTGRETEAEPWYQRAADAGNTEAMNNLGVVLQGTGRTAEAETWYRRAAEAGNAPAMNNLARLLQNTGRAAEAETWYQRAAGNPDGEIRA
>NZ_CP018870|7505840:7577592|7505995_7506553_+|WP_075969519.1|DBSCAN-SWA
MIMGVKMWVGGCLVAAVAAAGAAWFTTAPETGTTHAVCGPDLGRDDVVAARSRAVAVVEAVENTRYREDGGSAYLTTRVKTLEAFKGEFGDVLEVTQGVKNGGSPGRYATEDPDRYAVLEPGRRYVIAVQSGSTTGAAGTEAWAWYAEPAERGLVGEREHWQEAIATPPETAASSACEDIDAPAG
>NZ_CP018870|7505840:7577592|7558553_7559108_+|WP_075969486.1|DBSCAN-SWA
MGEIEDAILRADQEAFTKDPPKTLKGQINFLLKQLKTTRAVAAELGVSQRSVERYRKGDRKTPPQPVATRIEAAVRARWQPVVRGRRRKEAATSTGITVETRARFGYTAPVGTTDDGRVRRLTVHLPPAYAQRLFDARARGADDRDLRGIVAEGLQEIYFKDGGTRADELRVEFTDIDYFDVSF
>NZ_CP018870|7505840:7577592|7535158_7535692_+|WP_075969503.1|DBSCAN-SWA
MSNALARLLEIAPAPSQPRDKAWSEVERTLAVELPNDYKELISVYGGSNWDDYLYILEPGCPNRHYDLLKWAEYQFRDLQDLWTFEKRPAELETEGSVVVPWATTDNGECLYWLVLPGVEPNEWTVMVNEARGPRWEHYSVSCTQFLASALTGELKSNILSSSFPLASHKFRRLSPA
>NZ_CP018870|7505840:7577592|7559403_7559634_-|WP_079273053.1|DBSCAN-SWA
MAAGGKRLSVHLADQDDKILVMALNHQTREQDAAGAVPAGVAVLRTVDACGAHTDHDGHAWWALLDARPAPKKRLA
>NZ_CP018870|7505840:7577592|7522597_7523797_+|WP_075969510.1|DBSCAN-SWA
MRFLHTSDWHLGRRFHTEDLIPAQRAFLDHLVDTARTEDVDAILVAGDIYDRAIPSLDAVRLFNRALHQLADLGVPIIMISGNHDSAHRLGVGSGLLARAGIHLRTDPDTCDIPVLFDDADGPVAMYGIPYLEPSMVRDRLEAEAVSHRAVLTAALDRIHADLTNHQPAGTRSVVLAHAFVTSGTGQPEERDESQESTSEREIAVGGVAHVGSDVFDGIDYVALGHLHGPQRVTDRIHYSGSPLAYSFSEARHTKSITLVDLTPNAVPALTRQPCPVPLRLERVSGFMEDLLTNPDHEPLKDAWLEVTLTDTALPFEAMARLRRRFPHTASLRHKPAFIPSQATNTPTYSQRIRGRGDLDIASDFISSMRGTDPTPDEHALLQQAVEASRLNEQQKESV
>NZ_CP018870|7505840:7577592|7533717_7534815_+|WP_075969504.1|DBSCAN-SWA
MAYGQPPYPYTPPPAPIRPWWQTSGVRLGFIGAAAVIMAIAQGLGILLMFASIAMIWISTGGLRHPWQVWQRIAATVGTLMLCLIVAGIAHPVKKKDDAKAAATPTTAATSKASETPAPAAVPQLSDYTGKALTEARKGAEAAGYTVGNRDASSEARGVVLAGNWTVCFQKVSDLAGGKKGVDFSVVKEGEPCPKEDGGALPWPVMPNVVGATYNKAMADLKAAGVPLERVSLEDVYLDTDTPTAEQAAKDGEEWHVCFQDPGKDGKVTSTTTVRLDLGRWSEASLVKSCPATKGTTYQIPANDPDYERPGTSTGHDDSSSSSGSTGGGAKTVHPGAFCSPGGAVGTANGKTYTCKGPGQNRWRQ
>NZ_CP018870|7505840:7577592|7573040_7573307_+|WP_075969474.1|DBSCAN-SWA
MRFFSVKGREYVALTVLGSDDFDALEVVEMTAAGRGALLLEFRMDEETATLVHLGAEVGIPLLRASLEIFRTDFLEPRRAAGLPLRPW
>NZ_CP018870|7505840:7577592|7549727_7550021_-|WP_075969491.1|DBSCAN-SWA
MINLHVRGESGTIEARAKHGVLWGPELAGLDQAVFPMLGHLLPYGDTVFNHRQVSTLLEEVPRLPAGVLTDEFARELIELGQVVLAGQGLYLWFLGD
>NZ_CP018870|7505840:7577592|7527529_7528303_-|WP_075969508.1|DBSCAN-SWA
MSELTSTRIRTTATRLGLPHLAEALSHYIQRADEAKMGYLDLLDLVLSEELAVRDDRRFRNGLRLSKLPHHKTIEDYDFSFQPELDPRKVKDLATLSFVEDKANVALLGPPGVGKTHIAVALAVAACRAGYSIYFTSLDDMVRHLKAAEDQGRLMSKLTSYLRPAVLVVDEVGYQPLERTEANLVFQVISKRYEKGSIILTSNKTFGEWGQVFGDEVLATAILDRLLHHCEVVSINGNSYRLKNRLAAIERDRNDAA
>NZ_CP018870|7505840:7577592|7541185_7541431_+|WP_075969496.1|DBSCAN-SWA
MEKTWFEEVFRRRPHPMLRLLGNLLLGAAQLVFVVAVITHFHSDWRWLVVPMGLWAMLADGRGVALAVQDLRRRDPAPAPE
>NZ_CP018870|7505840:7577592|7547656_7547920_+|WP_045322884.1|DBSCAN-SWA
MEALEPDELQRLVLAAVDPYIDRDILAREIAREEQQRRALRARRSPATAHRGNGQGGKVIAYEGATAPWIQLGQSVTPAAPGDMTGD
>NZ_CP018870|7505840:7577592|7517190_7517502_+|WP_079273060.1|DBSCAN-SWA
MNFDENEPQSVREERFTAERAERREARKAASLDSRGAHLGAVIVTVALVLLSWYGELIALGIVSGVFVLWFAAALAWAYVDGDHGRHALQRAYNVTFGWGDGF
>NZ_CP018870|7505840:7577592|7572224_7572545_+|WP_075969476.1|DBSCAN-SWA
MQQLGEHHGTDTVAQHLNRLTTATSWQEATGSALVGRLVDATLTSLTTPPGAPAPSRPRVSAAAARSRSTTTPTAAAAPGRPAPAEAAVPTHRQQAAPVRGAGRRR
>NZ_CP018870|7505840:7577592|7510138_7511197_-|WP_075969515.1|DBSCAN-SWA
MIATVLWERELHQRGGASVFVVGPDCVVLHERHTRLVCLERADGAVRWDVPLGTWPRGIVLAGDCVLVLPQAPNLLSCIDLRTGASLWSAPTPRWTGNLAVHSDTVVIGGWRGYTPMSGLDLADGSVRWTTSSPVTSVRTLAWAGGVLTGSGYEAVLLDPADGSDLARWRLPDPLAGPDAKAFVPLDTERVVAVCEASSLLTFGIGADEPARLGSYDPFGAVGYVHGSVWMLRSGRGFLAVDPADGTSRWSVEADRRVVVDPLPYADGLLVGDANGGMRQLGPDGKTVEGCSLPGRRLDALAAAGDGGLFFAAKGTFGSFTLAPKAGRPTTPAALSETPGPNVADIARVAEH
>NZ_CP018870|7505840:7577592|7562140_7566010_+|WP_079273398.1|DBSCAN-SWA
MDYLEIAETHLAGGVLKGTAGLANFVRAVTPFDPYNLTHPAEYRTNLNSTVAGLLVAVNDPIGTGKQMLDDFMKDPTEGVGKFLPELAGTKGLGAGKKAGTAAKHLDDLDGPGGKETDGPGRKETDGKGPHHGERPDPDKASEGTDPVDLATGRMYLPQTDVVLPGTFPFAFTRRAESGYRAGRWFGPTWSSTIDQHLEIDAKGVVLVSEDGLLVGYPHPAPGVPVLPVSASAPRHPLARTPDGDWTLTDPLTGAVRRFVPPADGAENGIAPIAQFEDPNGNHVVFEYDEHGTPLGLTHSGGYRLHFETEGGRITALHLSGGGRVLAYGYTDGNLTEVTNSSGLPLRFAYDDRARITSWTDTNERRYEYAYDDLDRCVAEAGEAGHIALTFRYDDVDPQTRHRVTRVTTAAGHTRQYLIDDRYRVVAETDPLGAVTRYQYDSGGRRTALTDPLGHTTRSTFDDTGRMVSYVRPDGREARAEYNDLGRPVKVVAVDGSVVHQTYDERGNRTAVSRPDGTVTHFGYDESGHLTTVTDPRGAVTRIRTDRAGLPLAVTDRLGATTTYERDAFGRVTAVTDPLGAVTRMEWTVEGKPLHRTDPDGRRRSWTYDGEGNCLTRTDGPDGGGVHFEYTHFDLLAARTDADGTRHAYTYDAELRLTGVRNPQGMTWEYTYDPAGRLIRETDFDGRVLDYAYDPAGRLVTRTDALGQRITYERDALGRTVRKDAGGTVTTYEYDVFDRLAVAVCGDSVLTRLRDRAGRILQETVDGRTLTYTYDAMGRRTGRTTPTGAVAAWAYDAAGRYDALTTSGRRIGFTHDAAGQELSRTYGDAVALDQAWDETGRLVEQRLTGAGQGVVQRRGYTYRSDGVLTGVDDLLAGPRSFDLDPRGRVTAVHAGNWTERYAYDDVGNQTSAYWPGAHPGGGEATGPRTYEGTRLIGAGRVRHEYDVLGRVVLRQKARLSRKPDTWRYEWDAEDRITAVTTPDGTRWRYTYDPLGRRTAKERMTPDGLEVAERTVFTWDGTVLCEQRTAAAAQEAGGIAVTWDHRGLQPLAQTERILGASQEVVDERFYAIVTDLVGAPAELVDERGGLAWRSRSTLWGSTAWNRDATAYTPLRFPGQYFDAESGLHHNYFRTYDPETARYLSPDPLGLAAAPNPVAYVANPHGWCDPFGLAPYSDSTRAAQGVDHQLNEAESGKDNHYLQGIGKDEVKLEKYLRGHLQSPANYVDSDTGARIIIDKTLDPSRPVAIIRQDHMIHAYHIEPEDLSNYITPRDGKDTAKWRTPKGDEVNE
>NZ_CP018870|7505840:7577592|7573667_7574636_-|WP_075971904.1|DBSCAN-SWA
MTTWQGWQRFATTDPVAPPQPGDPPRSTEERLAYHSSFVTIRTPAIHTLTTQVRTLMILGRHQQNTARPSLIVTGPAAAGKTTALLNVGRTCHLAHTRKNPAPPGSAHTAVPVAYVLVPPGATAKTLVTEFARYLGIPVTARMTQTQITDAVCHTYTQAGVQLVMIDEIHRLNPRTTTGAQTADLLKDLSERLPATFVYAGINVTDTPLFSGTRGAQLAGRATLVDCGPLPARHGTRQPFRDAITDIENNLDLQQHKAGTLPAHAPYLHQRTAGRIGSLTRLIRQAAITAICDGTERITKTALDAVRLDHLAETHHRPHRRR
>NZ_CP018870|7505840:7577592|7543037_7544801_-|WP_079273057.1|DBSCAN-SWA
MSAREERPALRSQTTSLHDYALFRRGIEPDGRAPAYGYPVPGDRLRSALRFREATRLLAQLLGPAVDDPDPVGAAATLDRRLPQLGVRPDLVHHPLARLPLTNESAALALGRQLVRTASDPTALGAGIHLVGRLGGSEDVPQLTTLALLQGFLRPVVTALSALRCDTEVLIRLMDLLDPQDHGVVIDALASREDPAARRWLLNLPVGPGTTSSRAHHIALAVRLADLLQDESVDASVLAQGGRLLTRMALATGSPAEVLGYGPAIAVYEALVRRADRLPPTLDHHAILLSLALDLSSGASVLLDWPPGLREELLERLERLLGTPAWAAVPDGGHRHRDRYRADWIRRMRREPLDRTTPNGLRIHVVEHDPEIGGHVEARILLDGRPLVPRLFPAGHSPSPEHVLGQDLLRATPEERTVTLSTAECDEGCCGTLSVTVRRDGAHVVWHGPRQNGIGPQLPEHRFDAAAYHAEVDRARADDTWCRPARSTARLIQAGLGERPGLLARWGILQSWCRPAGPYEDTVEVDFWYGPGAGRDPVGDEAGQWVRLTWRLPDDGRRPGVRAAAALERIAATDPKTYSRVTGGNAE
>NZ_CP018870|7505840:7577592|7560384_7560798_+|WP_075971905.1|DBSCAN-SWA
MGLAEEISAVRSVSGHSGRLLGEFRRAALLVPLSEGDGGGLMSGWQGGVRWIYAFTDEEALARFAVARGADAGAREWEYLSILGARLVDAVIPTVEGPTGVAVDVADEDGSMLFPPVVGIVPDAYAVDAGPDRAEAV
>NZ_CP018870|7505840:7577592|7554664_7555297_+|WP_079273399.1|DBSCAN-SWA
MTHRGDWTGDAKEDIVARVGGELRVYPNRGDGTLGAHIKIGSGLPTTAQVVGAGDVTKDGHPDLLVQHSNKLYLYAGAAGPAPSVAAPVIIGTSGWDVMDLTAPGDADHDGRVDLLARDTRDGILYHYLGQPDGKTFSDRTEYGRGYTNAFRPLIAGAADANRDGIADMWATAADGTLKFYKGDTSIHGPVDGPSIQVGSGGWGAIKSIS
>NZ_CP018870|7505840:7577592|7568927_7569542_+|WP_075969478.1|DBSCAN-SWA
MHPEFDRADVVNWLLAHDKITLPAGAGQASLLVRGERGATGRFRLDAPWLGLADDIEGTDRLSGWVADDADADALAALAAGPVGATLTRLTAPGAGPLAVLGDVRVTDRLWSGSGGLRITLEWPARLRGTTAHTGNGGVVATASRRPGPARTACAPATTAAAWTQSCGATNTAARRPPVLDWHAGGGLRCAQLGRGSVASVTSA
>NZ_CP018870|7505840:7577592|7548653_7549214_+|WP_159393485.1|DBSCAN-SWA
MDAAVREAAVARFLREYPLMEQAACDHPALLGCADVDWSQIPGCPAGVPVLLRGLLDEVAGPAALTVLENVLMNSVFHVSAVMPAVLPFLIRLAAVPDIAVRSGLVDFLVVAAELSSSVDADDERQVLLFGKDSDHPEREWCRAAFAAHASALRALLEDGTLPDGLISADDRECLLRAVEPQRRPS
>NZ_CP018870|7505840:7577592|7548033_7548237_+|WP_075969493.1|DBSCAN-SWA
MAHRSDRTGDAKKDIVPRVGGELRVYRVVGAGDVTKDGHPDLLVQHSNKLYLYASIAMRRAAVGTRS
>NZ_CP018870|7505840:7577592|7539327_7539744_-|WP_075969498.1|DBSCAN-SWA
MGTWGTGPFDSDLAADFVDQLEGLAHQQVIALLERAFQRVTDSEERVDGGDGAEAVAAGALVASTLPDSPIVIDPDDGPREPLPKLPASLRASAKLALDRVLQDGSELTTGWVDSADANQWRQEVRQILQALETPTDH
>NZ_CP018870|7505840:7577592|7508489_7508846_+|WP_075969517.1|DBSCAN-SWA
MSAGIAPDGPHTDIDGLCEQIRGSLAGWAPRLLGVHVPRSVCGPAEVARLVGAVANAAELTGLPRDGATARAELHTSAARASAAGERAGADVRAELTAVRAGCRRAAVALGLPVPVTL
>NZ_CP018870|7505840:7577592|7537756_7538653_+|WP_075969500.1|DBSCAN-SWA
MRAKTLDRIASYQESKDRWNLFRSLKNLIEQAVRDYEHRALVELLQNAHDAHDADDPGGRVLIRLDHDEGPHGAVYVANTGRPVSGSNFDAMTYIAQSDKRPEEGIGNKGIGFKSVLQLTGAPQVYSVAGAGSRVFDGYRFTFADETSLKDLLGGDVTLAAEVAADVFHLCLPVPLDGVPDAVNGFAADGYVTVLRLPLKSEEARAEAAEQLTALSADPPVLLFLRRIGSLTIEERQDGEVARRTLVRTERVDAVLDRLTVSTARVATTCFILRVRTTPVPAISHRRAPSVQPTRHET
>NZ_CP018870|7505840:7577592|7574719_7576837_-|WP_075969473.1|integrase,transposase|DBSCAN-SWA
MSARRTARPAVAVGAHVRFRGVKWQVVALSGQMVHLVGPDGGGEAVLAGYLFADPGFSVIGAEVPQAAPQWGLFETAPAAAREKALAWQRHVREVECGLADGPGSGGVVREQYDPARHTLAEREQAKAEELTALGFGRVSRTTVQRMRLAYRKQGLWGLLDHRTTRASSSTGRSDERVVAAVREALRRRRGRSRGTINGLFPLIHQILQDRHGPGAVPVPSQATLYRLVTSLARPGELPSGPVRQVPASVEGRAFTPATALRPGEQVQIDTTRLDVLALFDDGRLARPELTIAVDVATRAILAAVLCPSATKSVDAALLLAEMAVPHPARPTWPDILRMDHARALPYQQLATLDERLAGAAARPVVLPETIVVDRGKVFVSAAFTAACETLGISVQPAPPRAPTAKGIVERTFGSINALFCQHLPGYTGSDVTRRGPEAEKDACFSVAQLQDLLDEWLVHYHHRPHEGLRHPMMPRKALTPNEMWGALVAVAGYVPVPLTGRDYLELLPVRWQAITPAGITIRHRTYDADLLAPHRGQASPVAGRGGKWEIHYNPHDVRQIWIRLPDGELTEIPWIHRDHVHRPFDEHTWQHIRTQATDCNHGDAEQHEARLADALDQLMRRVHSGHATKTEQTLLARTAHVPLPTARNGAHGTEAPADSPEQRDDDTIDDLDDLDGLDDLPDDVSPAPATGLGLYNAHEEADKW
>NZ_CP018870|7505840:7577592|7567319_7567613_+|WP_075969480.1|DBSCAN-SWA
MEMVERLPFGMRTAVEATYVRCALCGAFGELVLDSGRLDEALARARDHVRETHPGADIPEALRLVPDVAFPPDGCRDVVEWVEQYNARNTLPVPGPR
>NZ_CP018870|7505840:7577592|7537098_7537512_+|WP_075969501.1|DBSCAN-SWA
MDPLLHLDRTLDDLDPPRWEAVPANATRLVRTVHGLRRVPLGELRPADLRTLLAQQVALPFVLPLAVRLLAEEPLLDAYFYEGDLLLATVTAPEGAWAALPELEARLRTIVAGLPGAAVKELPRGSDTDLARFIARG
>NZ_CP018870|7505840:7577592|7547309_7547570_-|WP_045322885.1|DBSCAN-SWA
MSSEDLGAVWVLQGFSKVDDFLRTEFPIGREQIMQLREVITPDADDPWMFDGYDVPIELWPAVDAILQCGPPDPGLDYQTGCYAAD
>NZ_CP018870|7505840:7577592|7527341_7527518_+|WP_107484881.1|DBSCAN-SWA
MESLGNLFMAAVWGIPLVTLLGGAVAVAAVTRWRRREIRALKRAEEEQGGPALEVSGR
>NZ_CP018870|7505840:7577592|7551135_7552773_+|WP_159393483.1|DBSCAN-SWA
MVSLSLLLPQQMAGATPAAASPAAGSAVVDPPLADGQVQQVGPGVYSTADKSFEIYETDVAVGLMSRSHTVTVQPDGVSRPESAPVARADMGIFGPGWEAEFVGGQLNRKLEQSGNTAVVTDLTMNAAATYALKSSLDFPDGGGVRKYATPEGDTLTETTRFNEATGTMVSTAVESANAATSLPDEDLSADADATAPSNFAQLAPTYTWKQVGTGANSWRVTGVGTAANSALSTVTYDTAGRVATVKDAEIGETTSRLLTVKYSTATTATGTTPGEFTGRAREITLTDGATVQTLARYSYDATGRLRSVANPAEGIDAASSYSYDTTGRVSAVASPANGNWELTFPAGSASPNVEPVGPARPAADAPLEGAGGITDPAAGPLPTDFINGEITDPQAYPRHCSAATDWLWYLKRNCAAWAAHYGWHKPTFKTTPTNHRVVGINYDGCSTPGPNVSRPGGFNFRTACDMHDYGYGLIGNTYKGYSYYLDRSKKSNVENAFHTTMKTYSCKAYFILRRPGCNNWAYAYYKAVSNQRWGGNPKNGADAT
>NZ_CP018870|7505840:7577592|7545212_7546466_-|WP_079273056.1|DBSCAN-SWA
MDMGERWAEYDGLRGRVPSWHPVGVVVRADGPVVRRHYGTHGTVEHAPLKPGTDIAGLVRHQQEGFAERGEPVEWKVYGHDAPDLSRALTAAGFTPGWERSVLIAEELPGEPDVLVEPRNDIRSLYAVREQAERAWGIAVGSPGPHAVPYAEMIADGASEDGDVYIDVLLQHREVTAVGWVYADLTRPFKVVGGLSSDDAEFVQGCTAHWRTQSSRPLLAEAGGLLRERLLKAGFMEAATVRSYHWRPTGTPEITRPAQFLDWLHDDGPLRDRFQTEFDFKPSTTSLPAISAPVPSAVWHLHAHHRPVPDLPEQIDAIVQRGLLTATKPGEFVYWLDWQHDGYRYDPRRTDLPGRPPRPGKGTYPNGDYYLHLTDDLRLGTFGHPWEQTLTVWGPPLLAAVEAELTELLGEPVRRRG
>NZ_CP018870|7505840:7577592|7532800_7533391_+|WP_159393488.1|DBSCAN-SWA
MTAPTPAPGHPQRPDDVPASAASEAGQPFTPQLANGPGKPDSQLNAKQKTVLGCGGMIALFLIATMFAAAVSPSDAKPAEAKPAPTVTVTVTATVTVTAPPPVVAKAPEPMQEAAPQTAQVPDMTGKSGDLLVEALKTAGFADGYKATSFHDVSGQGRTVLLLTNWKICDQDPKNKAVPITEKVSVGVVKFGEDCP
>NZ_CP018870|7505840:7577592|7566002_7566761_+|WP_075969482.1|DBSCAN-SWA
MSSRSGIPRDPAPGWPGYHAEPSYDPGQSRVFPAPLPAELRALGNDVRAADWPVRLAFRNSRTELLDTLCRWQTLRALAYVHLLAARTGDERLPADLRVVPDPEAVGEPGLPALLARLEHAAAGLPADLLDAVVCDSGGLLADNRFAASVLAAGLTADSRPGDPDKAVSRAVVLTSYWYEVPGLRGALALAWSANLFVRSWLGWSQRFVYGDPAGGLGITSDPRPPRPAASALPKWAEPLLDRIEQGPGAAS
>NZ_CP018870|7505840:7577592|7511983_7512562_-|WP_075969514.1|DBSCAN-SWA
MQNRPTLVVVSGPPATGKTTLARALAQQLGCPAIIRDEIKQGMVMSTPNHQPAGDDPLNIPTLDVFFKAITVLLQAGVTLVAEAAFQDRLWRPGLEPLLDLADLRIIRCVTPTSTITERITERARTDSHRAAHGDQALLADMEAGVYDPEQFKAISLDVPTLVVDTSDGYMPETAEIQAFLRTPPPSPNPRR
>NZ_CP018870|7505840:7577592|7550191_7550410_+|WP_159393484.1|DBSCAN-SWA
MPIRRVRVVAVSAAVVAMAAVAGWDPAALLGRSKAKEAVVRVDQSGYVTGEVKVAAVMGDEEALAGAGFVVP
>NZ_CP018870|7505840:7577592|7530852_7531236_+|WP_075969506.1|DBSCAN-SWA
MTHANDSDDPLQLLMGLEVSDVSFVRDYVELHFDGPILRALSDPSGVYGGREWSFPAPGSLELMRCYIGETVDGYELDPDRILALDFGEHRFVIPLDSDSSGGPEAAHMVDVDESGRASVLGGMWIW
>NZ_CP018870|7505840:7577592|7507812_7508277_-|WP_075969518.1|DBSCAN-SWA
MPAHSKSVFVRPDPRRLLVLAAPAVLVALNQGLTSNGQVLPRPVYLALGAAFAVCAFALRWLLAVSIADGYIAVSRGLTPHRLALADLDSVEVEEAGRLGYVIRCRQAGEPELKVPLTMMRQSDQRLVIEAVHAAVRPGVLRGGAALRAFTTTP
>NZ_CP018870|7505840:7577592|7542251_7542539_-|WP_045322888.1|DBSCAN-SWA
MWPNAVADALSRFEWAFKQPGRYLNASEACSPGIEVEDARDDLERAMLHLPPGAQRDLGRLITRIDEEFERRTLPEPNYTEWAMHGWWWTRMRER
>NZ_CP018870|7505840:7577592|7505840_7505999_+|WP_107484691.1|protease|DBSCAN-SWA
MVAAHELGHALGLCHKSGSGKNAVSSVMWPDVAQYPDAPTDVDKANVKKLWG
>NZ_CP018870|7505840:7577592|7560797_7561355_+|WP_075969484.1|DBSCAN-SWA
MAGDADLEVSPAAVKNIQDGLRRAVAELRESGDAAGASMGAGFSDLSMTGMEAGHAGLATDFEDFCERWEWGVRSLVQNASALAGNLGIAAGTVWEEEHYMQGAFKVVANAAYGNPHASEDEIEQKSWDDIWRADVYKPDYSDESFEKSDADIKQTWSDTGDKLTSSGKIGSLKDLLDQAGGGGN
>NZ_CP018870|7505840:7577592|7576833_7577592_-|WP_075969472.1|transposase|DBSCAN-SWA
MDSGSGFEAVFLDPVGQSVQQRWADAAMTVAFEELPPVSAFPVVPGRRWGPGLWWSATTGRHVAAGSNAMRTQLMALDRDPRVTGLAGRPVRLLWRDERGRVRSWVPQLFARYRDGTGLLADCPSHPDAGGERALGAAHAVARACGDIGWAYRRLSPLDDVPASNLKWLAGYRHPRNAGRPGLTPAAVEAFARPRPLIEGAEAVGDPIEVLPVVFHALWHGQLTTDLEAPLHECVPVGPRDWNGLGRTGGAG
>NZ_CP018870|7505840:7577592|7516515_7517025_+|WP_075971902.1|DBSCAN-SWA
MRHDWSGPAPDGWENRDWRNVPGPFYTAGTDNCFTGRQCAPEHVAYEDEYCTEFVYRQPVEVAGVHELTCAGECDPFGAYGGDGDRHWTPELVQDWWSERRRAREWAVRVGWGEWATSEREQFRDAAAGARAYLAHLDHGLGEYLRDYMFWLSEGRPATPGERLPELDA
>NZ_CP018870|7505840:7577592|7509151_7509667_-|WP_075969516.1|DBSCAN-SWA
MTMPSSTGLLRLAFDGFHQARARLGECLSAHGASTDAVAIPAAETIYWACVLDEQLTSDGGYRTVRRRAIGDAMRGARWVRNRATHALALTVEQTGGLSLPLQVSITIEPVVGRWLRADRLPPEPPKYVDAAGRTAYDKTFADRPASDPVEDIAQWFANEHGRPGSRLRAM
>NZ_CP018870|7505840:7577592|7528299_7529718_-|WP_107484686.1|transposase|DBSCAN-SWA
MVLDPHRWLELRRFRPLYASGAMSLREIAKETGLNRRTVSKYLKNPASAGLPRRESDGRQPRRVVDEIAPLIDAMLRSEVLLKGSVIHERLVADYGVAINYQRVKIYLQEARPRIAEELGISPGELAGLHRRFEVVPGAQAQVDWGDEGRVLAHVGIPKVYSFHMTLSYSRDPFCCFTTSQDLATFFDCHRQAFAHFAGVPMSIVYDRTKTVVRRHVAPGEAVPLHPEAVAFAGHYDYDIDVLAAYRPQGKGRVERQVNIVRDHVLAGRAFSSLEEMNAAFAAWVPLRRAKVHSTHGEVIGHRAARDHTALRPLPGTPYVVAQRHLRHVGKDCLVAFDANLYSVPARKVRPRQLVEVRATKSQVSLHSTVPDAGGLTLLAVHARAVGRGAHVVDETHWDGLPTGAGRRVTTGDALPSPRRGRPTGSQTGPLQALLSRSAAAHVEVGRRPLSVYDELTGTRPFNPPAPTKDAR
>NZ_CP018870|7505840:7577592|7540772_7541099_+|WP_159393486.1|DBSCAN-SWA
MVRRKKEKKKRPDWGIPKGIVLLATPEGWRHSVLTMEGGMLCGRLDVPINTDPQDARAAAARMVTELARDFHDTDVEVSWDPPREPWSWTAQVTLPAGTEPSPPDSEG
>NZ_CP018870|7505840:7577592|7519248_7519560_+|WP_079273395.1|transposase|DBSCAN-SWA
MGMKHYPAEFKADAVALYQSRPGATIKSVAADLGVNTETLRNWIRAADGRRSGAHSTPPAAAQSGGDAVQAELAAARKRIRELEEERDILRKAARYFAGETRW
>NZ_CP018870|7505840:7577592|7523798_7526807_+|WP_075969509.1|DBSCAN-SWA
MRLHTLRLQAFGPFASTHTIDFDALSADGLFLLHGDTGAGKSTIFAAICFALYGKPPGDRDLLLRSHHAPAGLLTEVTLEVTLAGRRLRIDRIPAQMRPKRSGEGETSQKAETRLSEWAVDADGQGRWEPSSKSHQEAAVEVTDLLGMSREQFCQVVLLPQNEFTKFLHADAHGRRELLGKLFRTGRFSFIERWLNDHSRTTEKNRDATRADVLRLAERIHQAAGPDLETEYTAPTPDDPNTLTEPARAWAQDLLRVSHTDHARTLQAATTAKENLARQQTFEAAARELHQQQTTYTSARQQLDLLQEQTPHQDTLIQRRDQARRAQQAAPLLHAADTAAHDHTRAQSVERSARERLLPEHKDLDASRLETAEHRLRAEAAILTTLIPEEDTVRRLTTELERTDAERQDFATQQRTAQDWLEAEPARRGALEARREAARQAEEESRRHQTALDGLKTRLEAARRRDTHLAKVTKAEQQLADAEAVTGQTGQDYLTIRRRRTEGMAAELAATLTDGTPCPVCGSCTHPAPAAAQDGQPTRQDEQDAEALHEQAKTTQKAAAAVLHGLREQAATAAGEAGDTPLTDLQTQHTTLTTELTDVLDRAADQGTVQEELLALDGEHTAQTQQHSTATAGLSARNAHYDTLTQQLTELTAKLTAARGTYPTVAAHADDLTRTAHRLKETAEASRSLAAAVQTLAHRTDQATLAAKDQGFDTLALAQQALLNDEDLRAIEEEITQWREACAAHTAVLDNPALQQAAAQPSANLDAATAARATADDQHAEAAAAASAAHTRSQALTALAANLGTAIQRLQPLEQAHLTARHLAELVTGNSPSARVRMQLEAYVLAARLEEVVTAANTRLHIMSEGRYNLSHSDHQAARGARSGLGLEITDSWTGRPRKTDTLSGGESFFASLSLALGLADVVTHEAGGNPLDTLFIDEGFGTLDEDTLHKVLDVLDSLRAHDRTVGVISHVPELRRRITHRLHVRKSPAGSTLAHLTEAAE
>NZ_CP018870|7505840:7577592|7541556_7541994_+|WP_079273058.1|DBSCAN-SWA
MLAEAVVYPEIGPGCTLTGGVWWLYYDEREVTPAGALDIDHMVPLVEAWDSGAAAWTAARREAYANDQGQLASLVAVTARSNRSKADQDPAQWLPPAPDALCRYGAEWTATKLRWGLAADEAERERLLDIAAGCSGTDVEFTPAP
>NZ_CP018870|7505840:7577592|7530309_7530639_-|WP_075971903.1|DBSCAN-SWA
MTLTDLRDGFRDDDQRQCVQAVVHSRLADDREPQECRYLMRFWWQLSMPYQEVSLEELRLNVGRQKLDALMELISAIRSSHDEIDAWLADAEKTFPVIQDRGFSSDRSD
>NZ_CP018870|7505840:7577592|7536364_7536841_-|WP_159393487.1|DBSCAN-SWA
MAKVCWSAERSTNVEYASFRVGAFSLLDDTVMEQLPPAAGGLAVGEYAVGIGSLVHTHFDVDVLVEVWDEAPPVLAGQEPLGEASIAVRSGIFAVYDFWGAPRGEPIPLGGPARYALRVYRFPMKRPGAVGGAEGLETYAVHVWQAAGEAGGPPVLLE
>NZ_CP018870|7505840:7577592|7519556_7520183_+|WP_107484688.1|transposase|DBSCAN-SWA
MNRCQFVDDHQRRFGVKRLCDLLRIARSSFYYWRRTAAARTARQAAEAGLAARIRKVHEESDGTYGAPRITAELRDEGERINHKRVARIMRTIGIEGVRLRRRHRTTVADPAATKAPDLVGRDFTAAEVNTLRGGLLGRCLLRGLLLRRRHLVHGRLSPGLVVGLAAQLAGVGDGLLQRGHQVHDRGRRRLLIVGRGSRCSAFAAMTS
>NZ_CP018870|7505840:7577592|7572550_7572862_+|WP_157879710.1|DBSCAN-SWA
MTGRQRRAGGSALAGLVLATAGWWAQWSGYEVVGTALTLLAGTVVLAGAWRSGVLHLPQHEAGRQATQQQRARDSGCRCSEGSSSCAPCSVLYGPLHLLATLL
>NZ_CP018870|7505840:7577592|7538567_7539107_-|WP_075969499.1|DBSCAN-SWA
MADDSTSTFQAGQTGLIVRIPEAEPSVRGWREQLDPSAQAGVPAHVTVLFPFLDESRIDALVYSALADVLASHPAFDLRFERCGRLPEVLYLVPEPDTQLRQLTEAIADRWPEAPPYGGRFAEIVPHLTIAQGQEDAVLEEIEADLADKLPFTSHVASVELMVHDGVKWQERASFALGE
>NZ_CP018870|7505840:7577592|7520497_7522327_+|WP_030035897.1|DBSCAN-SWA
MYLDSYSARGFRSLAQVTDIPVSGPTVLAGRNDGGKSAVLTALAFLLGTHRLTDEDRTYVQDEEGSKGRRCAETWVEGQFRLDAEEQAHSGLGECVRIRRRSLLGEATCLEYFGSQPADPQLRDLGRLLKPALTALVAEYGLSPAGNLKEDLLAELRAHARTLPQDEGWQPLPKTLEERLPQLLSFGGKDESPDDAVRTALSSSYKTHLEDETLQGRVREIEGEITQRLEKEADSLCLHIRQHCAEYVSVNVKPLVSFKGGFQGAPLHVSRADGEPVDLTRAGQGSTRRIALAVWEWTSNLLENAELAASAEQGNTQPTQTIVVYDEPDTHLDYRHQRTVMDIIRKQCALPHVSVMVATHSMNLIDGVDIADVVHLSLGPGGRTVVERLDDDQHDGIDFHLGQIAASLGLRNSVLLHERCFLAVEGDTEQKSLPLLFRLAQNMSLQAAGIALWGCENNEGALHLARYLVKHQRTVMLMVDADSRTNKLFKDERLRRAGLDLEKHVSYVGEADGYNELEELFSDEQWATAANTHWPRPAPQTWQAHDFTAHRDGKKFSARILDMIQNQAGNNSPNGKPAMVYGLASTLTTAQDVPRQLRDIFTHLQELAH
>NZ_CP018870|7505840:7577592|7512797_7513268_+|WP_075969513.1|DBSCAN-SWA
MTTEEYLSTIDSLAVQPFPEVTYVDASGGGGPEHHVRELQVSRDFWDDDDGRAWVEAEAELQARLDDLAARLTDRWGSAFVADLGPYLSASYEGEPVPEPLDYLSQQAVSMQVWPLPDNGRWLALALGQADKELPLILFAAVGRASALGLNTSGRS

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_107484691.1|7505840_7505999_+|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_075969519.1|7505995_7506553_+	hypothetical protein	NA	NA	NA	NA
WP_075969518.1|7507812_7508277_-	hypothetical protein	NA	NA	NA	NA
WP_075969517.1|7508489_7508846_+	hypothetical protein	NA	NA	NA	NA
WP_075969516.1|7509151_7509667_-	hypothetical protein	NA	NA	NA	NA
WP_075969515.1|7510138_7511197_-	PQQ-binding-like beta-propeller repeat protein	NA	NA	NA	NA
WP_075969514.1|7511983_7512562_-	ATP-binding protein	NA	NA	NA	NA
WP_075969513.1|7512797_7513268_+	hypothetical protein	NA	NA	NA	NA
WP_075971902.1|7516515_7517025_+	hypothetical protein	NA	NA	NA	NA
WP_079273060.1|7517190_7517502_+	hypothetical protein	NA	NA	NA	NA
WP_079273395.1|7519248_7519560_+|transposase	transposase	NA	NA	NA	NA
WP_107484688.1|7519556_7520183_+|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	9.5e-07	31.3
WP_030035897.1|7520497_7522327_+	ATP-binding protein	NA	NA	NA	NA
WP_075969510.1|7522597_7523797_+	exonuclease SbcCD subunit D	NA	NA	NA	NA
WP_075969509.1|7523798_7526807_+	SMC family ATPase	NA	NA	NA	NA
WP_107484881.1|7527341_7527518_+	hypothetical protein	NA	NA	NA	NA
WP_075969508.1|7527529_7528303_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	6.1e-56	46.4
WP_107484686.1|7528299_7529718_-|transposase	IS21 family transposase	NA	NA	NA	NA
WP_075971903.1|7530309_7530639_-	hypothetical protein	NA	NA	NA	NA
WP_075969506.1|7530852_7531236_+	hypothetical protein	NA	NA	NA	NA
WP_159393488.1|7532800_7533391_+	hypothetical protein	NA	NA	NA	NA
WP_075969504.1|7533717_7534815_+	PASTA domain-containing protein	NA	NA	NA	NA
WP_075969503.1|7535158_7535692_+	hypothetical protein	NA	NA	NA	NA
WP_159393487.1|7536364_7536841_-	hypothetical protein	NA	NA	NA	NA
WP_075969501.1|7537098_7537512_+	hypothetical protein	NA	NA	NA	NA
WP_075969500.1|7537756_7538653_+	ATP-binding protein	NA	NA	NA	NA
WP_075969499.1|7538567_7539107_-	2'-5' RNA ligase family protein	NA	NA	NA	NA
WP_075969498.1|7539327_7539744_-	DUF4259 domain-containing protein	NA	NA	NA	NA
WP_159393486.1|7540772_7541099_+	hypothetical protein	NA	NA	NA	NA
WP_075969496.1|7541185_7541431_+	hypothetical protein	NA	NA	NA	NA
WP_079273058.1|7541556_7541994_+	HNH endonuclease	NA	NA	NA	NA
WP_045322888.1|7542251_7542539_-	hypothetical protein	NA	NA	NA	NA
WP_079273057.1|7543037_7544801_-	hypothetical protein	NA	NA	NA	NA
7544399:7544415	attL	NA	NA	NA	NA
WP_079273056.1|7545212_7546466_-	DUF2716 domain-containing protein	NA	NA	NA	NA
WP_045322885.1|7547309_7547570_-	hypothetical protein	NA	NA	NA	NA
WP_045322884.1|7547656_7547920_+	hypothetical protein	NA	NA	NA	NA
WP_075969493.1|7548033_7548237_+	hypothetical protein	NA	NA	NA	NA
WP_159393485.1|7548653_7549214_+	hypothetical protein	NA	NA	NA	NA
WP_075969491.1|7549727_7550021_-	hypothetical protein	NA	NA	NA	NA
WP_159393484.1|7550191_7550410_+	hypothetical protein	NA	NA	NA	NA
WP_159393483.1|7551135_7552773_+	phospholipase	NA	NA	NA	NA
WP_079273399.1|7554664_7555297_+	VCBS repeat-containing protein	NA	NA	NA	NA
WP_075969486.1|7558553_7559108_+	DNA-binding protein	NA	NA	NA	NA
WP_079273053.1|7559403_7559634_-	hypothetical protein	NA	NA	NA	NA
WP_075971905.1|7560384_7560798_+	hypothetical protein	NA	NA	NA	NA
WP_075969484.1|7560797_7561355_+	hypothetical protein	NA	NA	NA	NA
WP_079273398.1|7562140_7566010_+	RHS repeat protein	A0A2H4JFP5	uncultured_Caudovirales_phage	7.6e-22	36.7
WP_075969482.1|7566002_7566761_+	hypothetical protein	NA	NA	NA	NA
WP_075969480.1|7567319_7567613_+	hypothetical protein	NA	NA	NA	NA
WP_075969478.1|7568927_7569542_+	hypothetical protein	NA	NA	NA	NA
WP_159393482.1|7569596_7572035_-	tetratricopeptide repeat protein	M1PCM5	Moumouvirus	4.0e-16	28.6
WP_075969476.1|7572224_7572545_+	hypothetical protein	NA	NA	NA	NA
WP_157879710.1|7572550_7572862_+	hypothetical protein	NA	NA	NA	NA
WP_075969474.1|7573040_7573307_+	hypothetical protein	NA	NA	NA	NA
WP_075971904.1|7573667_7574636_-	AAA family ATPase	NA	NA	NA	NA
WP_075969473.1|7574719_7576837_-|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_075969472.1|7576833_7577592_-|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
7579276:7579292	attR	NA	NA	NA	NA