CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP019119	Vibrio fluvialis strain 12605 chromosome 2, complete sequence	0 crisprs	csa3,DEDDh,cas3	0	0	3	0
NZ_CP019118	Vibrio fluvialis strain 12605 chromosome 1, complete sequence	1 crisprs	RT,cas3,WYL,DinG,csa3,DEDDh,csx1	0	0	5	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

356908 : 369145

Vibrio_phage(90.0%)

integrase

attL 360836:360849|attR 372837:372850

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_075989451.1\|356908_357283_+	regulator	Q9MCC4	Vibrio_phage	5.2e-37	62.2
WP_081381486.1\|357277_357694_-	cell envelope integrity protein TolA	NA	NA	NA	NA
WP_155761297.1\|357937_358936_-	hypothetical protein	NA	NA	NA	NA
WP_075989454.1\|358965_360183_-	type II secretory pathway protein	O80264	Vibrio_phage	1.3e-156	69.7
WP_075989455.1\|360163_361237_-	hypothetical protein	O80263	Vibrio_phage	2.3e-154	70.6
360836:360849	attL	NA	NA	NA	NA
WP_075989456.1\|361236_361608_-	hypothetical protein	R9TIT8	Vibrio_phage	7.3e-39	63.9
WP_155761298.1\|361612_363364_-	hypothetical protein	R9TE48	Vibrio_phage	1.8e-39	46.5
WP_075989458.1\|363446_363668_-	hypothetical protein	R9TI50	Vibrio_phage	2.6e-12	56.2
WP_075989459.1\|363934_364252_-	hypothetical protein	R9TIT5	Vibrio_phage	1.6e-34	68.7
WP_075989460.1\|364282_366367_-	replication endonuclease	R9TE46	Vibrio_phage	2.9e-254	66.4
WP_075989461.1\|366369_366699_-	hypothetical protein	NA	NA	NA	NA
WP_075989462.1\|366874_367243_+	hypothetical protein	Q9MCC3	Vibrio_phage	1.7e-27	54.5
WP_032081876.1\|367380_367692_-	stress response translation initiation inhibitor YciH	NA	NA	NA	NA
WP_024375550.1\|367700_368075_-	DUF3319 domain-containing protein	NA	NA	NA	NA
WP_075989463.1\|368176_369145_+\|integrase	tyrosine-type recombinase/integrase	A0A077SLE7	Escherichia_phage	9.8e-11	21.4
372837:372850	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1054809 : 1094038

Vibrio_phage(85.0%)

tail,head,portal,integrase,terminase,capsid

attL 1062205:1062219|attR 1098713:1098727

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_075989854.1\|1054809_1055523_-	KilA-N domain-containing protein	A0A1W6JP13	Morganella_phage	1.8e-22	43.6
WP_081381506.1\|1055901_1057041_+	DUF4062 domain-containing protein	NA	NA	NA	NA
WP_047461530.1\|1057608_1057806_-	hypothetical protein	R9TR72	Vibrio_phage	6.0e-08	47.7
WP_155761310.1\|1057805_1059392_-	hypothetical protein	R9TNN7	Vibrio_phage	2.5e-269	84.1
WP_075989856.1\|1059388_1059862_-	DNA-binding protein	R9TPX7	Vibrio_phage	9.8e-65	86.5
WP_075989857.1\|1059849_1060743_-	hypothetical protein	R9TRQ4	Vibrio_phage	8.8e-115	72.4
WP_075989858.1\|1060746_1061307_-	hypothetical protein	R9TMQ2	Vibrio_phage	1.2e-64	68.3
1062205:1062219	attL	NA	NA	NA	NA
WP_075989859.1\|1062726_1063386_-\|tail	phage tail protein	R9TQ05	Vibrio_phage	4.4e-103	82.2
WP_075989860.1\|1063378_1064584_-	hypothetical protein	R9TRT3	Vibrio_phage	5.6e-197	85.8
WP_024375124.1\|1064580_1064913_-	DUF2590 family protein	R9TMS7	Vibrio_phage	4.5e-48	87.3
WP_075989861.1\|1064902_1066720_-\|tail	phage tail tape measure protein	R9TRA2	Vibrio_phage	2.1e-309	91.7
WP_024375122.1\|1066901_1067186_-	hypothetical protein	A0A160DHS7	Vibrio_phage	3.0e-32	79.3
WP_075990216.1\|1067182_1067422_-	hypothetical protein	A0A166YHN7	Vibrio_phage	2.9e-25	70.5
WP_075989862.1\|1067390_1067732_-	hypothetical protein	R9TNR2	Vibrio_phage	7.1e-49	92.9
WP_075989863.1\|1067706_1068297_-	lysozyme	R9TQ00	Vibrio_phage	9.7e-78	70.4
WP_075989864.1\|1068283_1068484_-	hypothetical protein	R9TRT0	Vibrio_phage	3.2e-25	83.3
WP_075989865.1\|1068484_1068697_-	molecular chaperone DnaK	R9TMS3	Vibrio_phage	2.0e-25	78.3
WP_024375116.1\|1068705_1069161_-	DUF2597 family protein	U3PCG7	Vibrio_phage	4.2e-73	88.7
WP_075989866.1\|1069157_1070267_-	DUF2586 family protein	R9TNQ8	Vibrio_phage	8.7e-197	93.8
WP_075989867.1\|1070268_1070928_-	phage virion morphogenesis protein	R9TPZ7	Vibrio_phage	8.0e-105	90.4
WP_075989868.1\|1070914_1071406_-	hypothetical protein	R9TRS7	Vibrio_phage	1.3e-72	82.8
WP_047461574.1\|1071402_1071864_-\|head	head completion/stabilization protein	U3PFL1	Vibrio_phage	3.0e-58	75.2
WP_075989869.1\|1071972_1072692_-\|terminase	terminase	U3PCG2	Vibrio_phage	3.8e-92	70.8
WP_075989870.1\|1072702_1073713_-\|capsid	phage major capsid protein, P2 family	R9TPZ5	Vibrio_phage	1.5e-102	58.8
WP_075989871.1\|1073712_1074618_-\|capsid	capsid protein	U3PDG3	Vibrio_phage	2.3e-118	89.9
WP_075989872.1\|1074788_1076612_+\|terminase	terminase ATPase subunit family protein	U3PIL1	Vibrio_phage	1.2e-299	83.5
WP_075989873.1\|1076608_1077625_+\|portal	phage portal protein	U3PFK6	Vibrio_phage	1.6e-165	83.3
WP_075989874.1\|1077617_1078244_-	hypothetical protein	NA	NA	NA	NA
WP_075989875.1\|1078326_1078578_+	ogr/Delta-like zinc finger family protein	R9TNQ2	Vibrio_phage	2.8e-34	84.3
WP_081381508.1\|1078572_1078791_-	hypothetical protein	Q8HA64	Vibrio_phage	1.1e-26	87.5
WP_075989877.1\|1079311_1080847_-	DNA cytosine methyltransferase	A0A1L5C2B8	Pseudoalteromonas_phage	2.7e-180	65.5
WP_081381509.1\|1080856_1083760_-	replication endonuclease	R9TNQ0	Vibrio_phage	2.1e-250	51.7
WP_075989878.1\|1083833_1084070_-	hypothetical protein	R9TPY7	Vibrio_phage	1.4e-32	83.3
WP_075989879.1\|1084069_1084363_-	hypothetical protein	NA	NA	NA	NA
WP_075989880.1\|1084447_1084732_-	hypothetical protein	R9TPY3	Vibrio_phage	9.8e-20	56.4
WP_014205490.1\|1084743_1085283_-	phage regulatory CII family protein	R9TRR3	Vibrio_phage	9.8e-53	58.1
WP_041942596.1\|1085393_1085594_-	hypothetical protein	A0A2I7RNG9	Vibrio_phage	3.1e-12	51.5
WP_075989881.1\|1085730_1086378_+	phage repressor protein CI	A0A166YHA0	Vibrio_phage	4.0e-77	67.6
WP_075989882.1\|1086403_1086904_+	hypothetical protein	A0A0M3LNP7	Mannheimia_phage	3.3e-10	28.4
WP_081381510.1\|1086968_1088984_+	hypothetical protein	A0A2H4J2R8	uncultured_Caudovirales_phage	7.5e-05	26.8
WP_081381511.1\|1089019_1090129_-	DNA cytosine methyltransferase	A0A0R6PG08	Moraxella_phage	1.1e-111	59.5
WP_075989883.1\|1090420_1091464_+\|integrase	tyrosine-type recombinase/integrase	R9TMQ4	Vibrio_phage	2.0e-94	48.4
WP_032080865.1\|1091694_1092621_-	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_075989884.1\|1092610_1094038_-	deoxyribodipyrimidine photo-lyase	A0A1V0SGL1	Hokovirus	7.6e-52	30.1
1098713:1098727	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1497365 : 1508950

Burkholderia_phage(37.5%)

terminase,tail,portal,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_075990070.1\|1497365_1497473_-\|tail	GpE family phage tail protein	NA	NA	NA	NA
WP_075990071.1\|1497508_1497796_-\|tail	phage tail assembly protein	E5FFG7	Burkholderia_phage	4.3e-07	41.6
WP_075990072.1\|1497779_1498487_-	hypothetical protein	NA	NA	NA	NA
WP_075990073.1\|1498497_1498863_-	hypothetical protein	NA	NA	NA	NA
WP_020432119.1\|1498866_1500000_-\|tail	tail sheath protein	C9DGP7	Escherichia_phage	2.4e-48	39.0
WP_020432118.1\|1499996_1500179_-	DUF2635 domain-containing protein	NA	NA	NA	NA
WP_075990074.1\|1500179_1500719_-	virion morphogenesis protein	NA	NA	NA	NA
WP_075990075.1\|1500715_1501180_-\|tail	phage tail protein	A0A1S5NPS3	Burkholderia_phage	8.6e-05	28.6
WP_075990076.1\|1501179_1501629_-	hypothetical protein	NA	NA	NA	NA
WP_075990077.1\|1501737_1502775_-\|capsid	phage major capsid protein, P2 family	A0A0U4K5I9	Pseudomonas_phage	1.3e-64	41.7
WP_075990078.1\|1502817_1503636_-\|capsid	phage capsid protein	Q94MZ5	Haemophilus_virus	2.9e-16	31.5
WP_075990079.1\|1503806_1505531_+\|terminase	terminase	E5E3X0	Burkholderia_phage	4.9e-114	41.5
WP_075990080.1\|1505541_1506507_+\|portal	phage portal protein	A0A0M3LS06	Mannheimia_phage	1.4e-57	41.8
WP_081381515.1\|1506814_1507720_+	endonuclease/exonuclease/phosphatase family protein	NA	NA	NA	NA
WP_075990081.1\|1507731_1508202_+	hypothetical protein	NA	NA	NA	NA
WP_075990082.1\|1508332_1508950_-	DNA-binding protein	A0A0P0ZCS0	Stx2-converting_phage	3.9e-21	45.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP019118

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP019118_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP019118_1

302073-302183

Orphan

Consensus_repeat	Method
GTTGATGAGATTCTGACTAAGGTTAGA	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_CP019118_1

>merge|NZ_CP019118|1|302073-302183|CRISPRCasFinder
GTTGATGAGATTCTGACTAAGGTTAGAGACTCTTTGTCTGCAGTTGATGAGATTCCGACTAAGGTTAGAGACTCTTTGTCTGCAGTTGATGAAATTCTGACTAAGGTTAGA

>NZ_CP019118|1|1|302073-302183|CRISPRCasFinder
GTTGATGAGATTCTGACTAAGGTTAGA	GACTCTTTGTCTGCAGTTGATGAGATTCCGACTAAGGTTAGAGACTCTTTGTCTGCA
GTTGATGAAATTCTGACTAAGGTTAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP019118.1\|WP_062886151.1\|299365_300919_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NZ_CP019118.1\|WP_155761247.1\|313417_313582_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019118.1\|WP_062886144.1\|308303_310031_+\|DUF4297-domain-containing-protein	unknown	unknown	gnl\|CDD\|372918
NZ_CP019118.1\|WP_062886147.1\|302706_303177_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|277151
NZ_CP019118.1\|WP_062886150.1\|300995_301403_+\|H-NS-histone-family-protein	unknown	unknown	gnl\|CDD\|182380
NZ_CP019118.1\|WP_075988123.1\|297459_298341_-\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP019118.1\|WP_075988124.1\|313649_314612_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|140299
NZ_CP019118.1\|WP_062886146.1\|303237_303837_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237560
NZ_CP019118.1\|WP_081381432.1\|314643_317220_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP019118.1\|WP_075988120.1\|294992_295376_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019118.1\|WP_075988121.1\|295420_295921_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019118.1\|WP_062886143.1\|310015_312193_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|224125
NZ_CP019118.1\|WP_075988118.1\|292882_293533_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019118.1\|WP_044362214.1\|312742_313171_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019118.1\|WP_062886145.1\|304484_307361_-\|DNA-directed-DNA-polymerase	unknown	unknown	gnl\|CDD\|367375
NZ_CP019118.1\|WP_075988117.1\|292013_292886_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NZ_CP019118.1\|WP_062886148.1\|302402_302672_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019118.1\|WP_014204405.1\|298608_298857_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP019118.1\|WP_075988122.1\|296023_296455_+\|DUF2787-domain-containing-protein	unknown	unknown	gnl\|CDD\|371323
NZ_CP019118.1\|WP_075988119.1\|293655_294891_+\|integrase-family-protein	unknown	unknown	gnl\|CDD\|271182

Protein	Function_ID	Function_description	E-value
NZ_CP019118.1\|WP_062886151.1\|299365_300919_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	8.03554e-60
NZ_CP019118.1\|WP_062886144.1\|308303_310031_+\|DUF4297-domain-containing-protein	gnl\|CDD\|372918	pfam14130, DUF4297, Domain of unknown function (DUF4297). This presumed domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is typically between 207 and 221 amino acids in length.	5.20901e-27
NZ_CP019118.1\|WP_062886147.1\|302706_303177_-\|hypothetical-protein	gnl\|CDD\|277151	cd15681, PHD_JADE3, PHD finger found in protein Jade-3 and similar proteins. Jade-3, also termed PHD finger protein 16 (PHF16), is a plant homeodomain (PHD) zinc finger protein that is closely related to Jade-1, which functions as an essential regulator of multiple cell signaling pathways. Like Jade-1, Jade-3 is required for ING4 and ING5 to associate with histone acetyl transferase (HAT) HBO1 and Eaf6 to form a HBO1 complex that has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3, and is responsible for the bulk of histone H4 acetylation in vivo. Jade-3 contains a canonical Cys4HisCys3 PHD domain followed by a non-canonical extended PHD (ePHD) domain, Cys2HisCys5HisCys2His, both of which are zinc-binding motifs. This model corresponds to the canonical Cys4HisCys3 PHD finger.	0.0051778
NZ_CP019118.1\|WP_062886150.1\|300995_301403_+\|H-NS-histone-family-protein	gnl\|CDD\|182380	PRK10328, PRK10328, DNA-binding protein StpA.	5.86355e-35
NZ_CP019118.1\|WP_075988123.1\|297459_298341_-\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.02777e-17
NZ_CP019118.1\|WP_075988124.1\|313649_314612_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|140299	PTZ00273, PTZ00273, oxidase reductase; Provisional.	2.84337e-127
NZ_CP019118.1\|WP_062886143.1\|310015_312193_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|224125	COG1204, COG1204, Superfamily II helicase [General function prediction only].	2.32184e-44
NZ_CP019118.1\|WP_062886145.1\|304484_307361_-\|DNA-directed-DNA-polymerase	gnl\|CDD\|367375	pfam03175, DNA_pol_B_2, DNA polymerase type B, organellar and viral. Like pfam00136, members of this family are also DNA polymerase type B proteins. Those included here are found in plant and fungal mitochondria, and in viruses.	0.000128112
NZ_CP019118.1\|WP_062886146.1\|303237_303837_-\|hypothetical-protein	gnl\|CDD\|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	0.000517637
NZ_CP019118.1\|WP_075988122.1\|296023_296455_+\|DUF2787-domain-containing-protein	gnl\|CDD\|371323	pfam10980, DUF2787, Protein of unknown function (DUF2787). This bacterial family of proteins has no known function.	7.27902e-44
NZ_CP019118.1\|WP_081381432.1\|314643_317220_+\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.69381e-62
NZ_CP019118.1\|WP_075988117.1\|292013_292886_+\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	3.55405e-18
NZ_CP019118.1\|WP_075988119.1\|293655_294891_+\|integrase-family-protein	gnl\|CDD\|271182	cd00801, INT_P4_C, Bacteriophage P4 integrase, C-terminal catalytic domain. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. The P4 integrase mediates integrative and excisive site-specific recombination between two sites, called attachment sites, located on the phage genome and the bacterial chromosome. The phage attachment site is often found adjacent to the integrase gene, while the host attachment sites are typically situated near tRNA genes. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.94196e-26

>NZ_CP019118.1|WP_062886150.1|300995_301403_+|H-NS-histone-family-protein
MNELIKTLLNLRSLRAFARDLTMEQLEEAYGKFTTVIEERREEEAKIREEQAEKEAQLAAIAKQITEQGLDVNELISALSSNKPAKTQAKRQPRPAKYKYTDASGQEKTWTGQGRTPAAIQEALNNGQSLEDFAI
>NZ_CP019118.1|WP_062886151.1|299365_300919_+|GGDEF-domain-containing-protein
MFEKLNLRKLILILGVFSVVITLFNAFYSIYKVQRDLIVNNTMESNRVYAEKMAEMTDAFIESAFSQLKFSAHVLSSKMNNSQVLELEAERLRTQTDSFNSVVIVNTEGIIVAVSPETVQVKGVKLTSERSLQSLRAQAPIITDPFVSPAGNYLTSISYPIFSSSGEYLGYVGGTIYLEKKNILTTLLGQHGYKDGSYLYVVDRNHTLIYHPDKRRIGQVIVNNEVINDVIQGDFGGKDIFNSQGVEMLAGYAPVKNAGWGIVAQKSKQLTLSTLDEQMWKVFLESLPIGILTLLLIWVSSIFISRPLWQLASAVRNFESHVKTMDDLKKIKPWYFEASHLKISFLRAFSIVSNTIEKLHSDSLTDSMTGLLNRRGLDKAIESFRLENIPFSVLALDVDYFKKVNDTYGHDVGDELLKNVSQLMKNQAREHDVLCRAGGEEFMIFLPNTDLNRAFEAAERIRKSIEIYSFPTVGNITISIGISSWEGLAERIDDVIKKSDQALYKAKNNGRNRTEVN
>NZ_CP019118.1|WP_014204405.1|298608_298857_+|hypothetical-protein
MKKSIILLGLTCLFATTSSFAGGTLGGNPGDISQMKELLESKWNGKPGTQNTAAYGVIVQWQADVCGTLNGKETDATKCTAK
>NZ_CP019118.1|WP_075988123.1|297459_298341_-|WYL-domain-containing-protein
MKEHDTLAKRLGIILTRLNTGERLYLEELSREFGVSERTLQRDFNERLNYLPIQREGACYFLDPKVLGRQTNHEISTLLANMGLDTLFSGKHYLSNGVLNNKSTPPFLFKNPHIEDISNYSNVFEKLVESVQRRNVISFTCEGKTYDEFHPYRLVNEYGLWYVAGTQRNRLESLRIVKIRDLIRYEDKYSPDPSIEQKLAGREYEGELLNAVEVLMQMSSKMTDAFLNESNTDDFQVLKELDSGSLLISHQTKNIPRLLRQLKAWLPHAEVLSPDWVRYLLKQELQTYLDSTK
>NZ_CP019118.1|WP_075988122.1|296023_296455_+|DUF2787-domain-containing-protein
MSLVFNTEKFLLPVSIDLQDALNRVISESGKWTPMIQSVVFNFRDSSYSSENGGWHPVEIRLVRLYDQWIFDYITDFAYCGGPYPELVKEVDFNFSSGTASFSYVPELPITSSEVMEFYSMWESNFLSYIGMGVFDEIKVTVD
>NZ_CP019118.1|WP_075988121.1|295420_295921_+|hypothetical-protein
MARKSNQQQETVQPEIPETNEQVTVTDDQPVDHFTNIVREGKAKKLSPKTENHVFYEIAIHDEETELYIRMSGSQGGGLHSKEWIPLKDITAVLDVQGDKPFKSSVMRCVFSGQSANNAGFMAACCRGLGLIIQSEKSVFLHVLAPDYEQRRDELLSLVDAETKAE
>NZ_CP019118.1|WP_075988120.1|294992_295376_+|hypothetical-protein
MKTVNKFEDIQSLPMPDGVKAKLLEHLIEPFGDEESTKAFWDEVGTTLYLIEEGDTNEKLNEESEEDLHFLRFVTNYPEWVLLLNDDDCPWLLAVAIVTMEGAGVYCCAPINSPTFPVAKLADQAES
>NZ_CP019118.1|WP_075988119.1|293655_294891_+|integrase-family-protein
MSKLQRLTTTFLNNLKPNPANAKSTDYEVNLSAMKDSGLPTGVRCLVGKSGGKRFLLRYTSPVTGKKASIGLGKHPETDLATLRKTAKEYRQQIIEGIDPKLERDNQTAEKTMTLARFFDEVYLPLAKQKRSWKDDAARFRLAKSIHHISIHDLTAADIIKVQMEMQNTVTIKGTPYAPASINRVLALLKTINRQSYKLMDTPLIADKVSLLKEDNVRTGYLSEAQLKEFIGHALNHEDKSIGAYLALLFLTGARDKELRLRLKSDVSWEDKSLTIPHTKNGSSHVIYLSDYMLEILRSVPHVANNPYLFPGRKKGKPVGQPRHAFKAIKAKMGLPDIPGDKANLTLHSARHTVGSLLASQGVSLHDIAKQLNHADLSSTRRYSKLTVGRRREIGSRLSDMVTAKPELRWE
>NZ_CP019118.1|WP_075988118.1|292882_293533_+|hypothetical-protein
MSDEKDIDLEYLKLNVEVWKKIVDVQQHFNDLEMKVRNFGLLIVSAFISAIGVSLKSQYEAEVVGYNIPVATFLALGSFIVWMLVFLVDVYWYHPLLKGAVLKGIEMEKQIKTQLPNINLTGKIGEESAVSILGFKNVRSTTKAKIFYLGIGGVLLVLTVLIFCMGEKVPDIGNTSSQNIPEKTESKINDVTPNLTKVEGQTSPVIPQELSTKSSD
>NZ_CP019118.1|WP_075988117.1|292013_292886_+|HAD-family-hydrolase
MKKTVLITDLDNTLFDWFSIWYASNSAMFDKVYEITGLSSDVILPEVKKIHQEHGTAEYAFLLQNLPSLLAMYGSEDGINEALDEAIHAFRSERRKHLRLYPTVEDTLKTLKNIGVLVIAYTESKSYYTSYRLKKLGLDNYIDYLFSPPDHELPEELGSGTKFSFSLTKPKHTPEGETKPNPKLLLDIINDLGADVEDCVYIGDSEMKDIEMAQQACVTDVFARYGTTHFENNAEGYELLRAVTHWTDEDVEREKRIKENYHHIPPTYTVDSFSELLEIFNFQMFKGADS
>NZ_CP019118.1|WP_062886148.1|302402_302672_-|hypothetical-protein
MNMSIYDLIVNAFTAEAIRTNQNRQTRLREVRKVGQNIESKGGKIQHWDQILDELETALVHDYDTKRDSFGYKETAKRLKQVISEVTGH
>NZ_CP019118.1|WP_062886147.1|302706_303177_-|hypothetical-protein
MSTEVKKNTVNLFSVKLQVSTSILASINITDSNISVRAASGKQLAHLTLKDEESEQNLDTLFADLEKLCIRDANYWITLPTGSWVRKNAILGYECHLSEKYQGLILRTQGNRILSFIPCDDLDTQLVIKQEIQKAAAASSPSRRYKPTWNFYQNAV
>NZ_CP019118.1|WP_062886146.1|303237_303837_-|hypothetical-protein
MTDVNKALEFTENLLSELADAVVNALSNAGAGRVVDKELCEQAQYDIGAAMCEAKQLFQGNKNKFGKWRDENIIGNGKRTVDKRTLTRWTNLCEFGTLDECRKVGFTKVYKLSSKRYAPLREQIKQHLEQHPDVESDTINEMFNDFATQLKTEKKQTTPVVNDDLVDKVSELEARLKELEQENANLRQQLEGQPTLEAA
>NZ_CP019118.1|WP_062886145.1|304484_307361_-|DNA-directed-DNA-polymerase
MNNENKPNHVEAIDKELDEYFQAETTDQTKESTSIELDQFLTQEQTDEYSSKAVDDELDIYFENEQQSPWQALKGDDEAVHIGIDSEYVYNPEENRNDILSYQYYLIAGEHHMSDVVLTPVADVIKKFRASNKSREDELKAINRIKKPRKKFEEFLVEVLQTAMGRGFITGWPKKIYIYAHYLRADMVSFEAFWDTSQKAKLEVVRSTLTSTRGAYGIDLDAVGRTKQASEPVHFTDKNGKKRESRVRFVDTLLLSPGQSGLDNVGELIGIPKEVIPAPYRKDRMDELLVENEPLFLRYALRDAEITVKYGLEMQRFALNDIKESLKGKIPANRLDKLQFKHLPSTLGNFSVSLFKALTGDKDALNQALGMETKTIQYWNQTQGRVMQKKETVITAGRRIFEQLSVDCFHGGRNECYVFGGVNLGDYNDFDLATAYVNALMDIKPVDFEKSFTSTNINDYLGHKMGFAYVKFKFPEHTKFPSLPVRTDLYGLYYPLEGYSYCTAPEIEVAYNMGCDIEIQFGVIVPWIEDKEPLFKGFTELIREQRQKYTEEGDKFREKLWKEIGNTLYGKLGQGLKGKRGFNSSDGLSKNIPHSPVTNPYFAAHATGFVRAVLSEQLAGLSTLDDKGNHDGVNVVSATTDGYLVDCTEEQLHVSGTISQRFSKICEQTGDGKMIKHKHHAKQIIAMKTRGQITGEYGDTEPVIAKAGVKPPESALSSAKDENAYMVELFLDRYPGQKIPNNSLISPRDMYLKDMDLIEIQREKTLNLEFDFKRKPVNPRMTKIRHPKGHIVEHIYFDTVPWKNEQEGQQTRALFDGWRRDNCLKTMEDWENWIDYSKTKPLLKGSYIKYEEGGSQGALLKLALRALSKESYGLTKTINGKKLTLKQLTELFNNAGFRIADNAISNSRDTAFRPNVLAATPRLIPLLRWLIATFPDMEIEHFFHKDELDEVKMMLKNS
>NZ_CP019118.1|WP_062886144.1|308303_310031_+|DUF4297-domain-containing-protein
MSTSEMELSDSGGPAALKGFVYQNFVAAYYALRMLEDKNLLSVRCEAVDDVDAIYTDKVEYIQVKTTDKDSKWSVSEFADADTKSVPPTGQQRKNQTVSKEDSILHKSILCDKGKLPSYFRIVTPRDVTDSLRYLKTSLNTRNEKADLKAPLLKRLRSSVERNRPKKSAPFTSPNGNGVEYWLDHAEWEVIPLQEVLESRCTKLIRQAAQRKGIYLIENGDPERILCSLLNNLFKKGAASRVLKSIDDKSYLREDFIPWFESEIEHYAHLNDEHVKIYTTDSARLQAVLSVFFQDSDIYKEEKYDGRKECTGLQGEYHRRKYCYDLIARNLYKWFHEVLLLPNEIADNAPDKITDKFKLLTQRYKREANFINNLVAKALLHSTVRTTYKSQPIAANLHVDDSNSTCFDNIHIVLNDHEPDNLIMGFSRLINKVDDLSIASIVTEFSNLLESEAFSVQKEKVLIAKKDNYLLDHDIDDILSSSSSLDKNLDRFRFVFFIGYESDHLSCNAKELVDGYEKHLKSELKMKFKSLVDKMIREDDYFEDLHIEVYLYPIPSLNSLVSEIKSQVELKWTTA
>NZ_CP019118.1|WP_062886143.1|310015_312193_+|DEAD/DEAH-box-helicase
MDNSLEPKQYLENVRNEKLSPFSYLKKANECLSSPDLVPIGQEFIIRALEALPLFEKQSLLLQNLLRTAGLYPYLKKYFTELSPEKEFVIDIYKSNFDDNFIFHSMQARVFKLLLSGRNVVLSAPTSMGKSAIVDALLASNNFNKIVIVVPTIALIDETRRRIQARFGSTYQIIHHGSQVKRKDKVIYVFTQERVNERNDLKNIDLFIIDEFYKLADTKDAQSRPRAFALNIALSKLLTVSKQFYMIGPYIDAVQGMSVLTRDFVFIPSNFKTVALNIHKYNVEPDNIEQKNKKLSEIFESYKGQTIIYCKSSNSISNVIDFLILNKKINQDDSCFSSDSSLRKYYKWLKRNYGADWGCTRALASGIGVHHGALPRAIQQKNVEVFNSKKIKYLICTSTMIEGVNTSAENIVIYDNRNGTPKVDSFTHKNISGRAGRMGQYLVGNVFCLEKLPEKESQIVNLPIGQQDDDSPINLLAGIQPDHLSEQSNHNLLQFTKTSDIPIEIVRKHSSYDIEILEQAYELIEELSVIDMEQISIITKPKRYQLEILTRFIKKVESRALSRQQLHYEDSDELYNKLRAYIYADSHTSYIRSQISYIYNANWSASMRSNATDRELTVVRNIFKHAVARAIALLQDLLNYKFVSNGLEPKANLGWLLHIFENSHLPASFSALEEMGIPIETLEKLVTNRLSEVDIDILVRYLRMNLKYFEQLNSVDKMFIKQAIF
>NZ_CP019118.1|WP_044362214.1|312742_313171_-|hypothetical-protein
MKNHLLSSAKNLCLTLSLIGASSFAWAGHHLSVKGTDQDVSGGTVTADMIMAGENGWMVVHRTDSNMKPGPVVGYAPVKKGSNQAVSAILTEPVKSGDMLMLMLHGEAGGMKTGVFEYTLGAKTDGPIREDGKLVMAVITAK
>NZ_CP019118.1|WP_155761247.1|313417_313582_-|hypothetical-protein
MGLSKKLTTQPTFNQSHLPQGKEGYVSPEANIHCTASVQSRIALHHFGLMNRSK
>NZ_CP019118.1|WP_075988124.1|313649_314612_+|2OG-Fe(II)-oxygenase
MSLPIIDISALHSANRQDWQPVIDQIDSACRELGFFYVVGHGIPQQQFDHIESMAGKLFALPEAEKQQLSIEKSSNHRGWGRLNAEKLDPKGALDCKESFDMALDLSPYHSQVARCPELYGPNQYPNIEGFTQAMIQHYSLTLDVGLRLLKAMAIALKEPEDFFTQYFTLPVSVLRMLHYPSQMKETNGAGAHTDYGCITLLYQDSSGGLQVLNKQDEWMDAPPVAGSFVVNIGDLMQRWTNDIYRSTKHRVASPTTGRTRFSMPFFVEPDFDTPIETLSSCLAERPEQGGYPFITAGDWILSRFADTYSYRREEESLTV
>NZ_CP019118.1|WP_081381432.1|314643_317220_+|EAL-domain-containing-protein
MSLPGNISALFTVRIATVLTLYATGLAIVKSSSVNIRGVKPVCRRSRGECMPESDSPIKPVVTNVSSPARFVPLHWTLDIENQTFNHYADQVNDLMAPLLAFSALEQWLALFDLQAREQAEQLVEQVLTQGDKRALNAVLRLYPNRAVYVVFSVERLSKQLLQGDIQPIFELTQVEQAIHWLEALLNHSAAGLLITNREHKVLGCNSAFERFTGFQQSDLLGLSSLWLFEESTDITGTSQPRVSIKHTSGISQAYHHQSIRLMDNDDHSVVLSLFSLVESAPALSACPVMDKAAFIAQFESLHQNRMMNDLYVVMTLSVQQVNGAQLSMLLDVMPRLKECRLFGKIRDDLYLLCVTCPLPMMGDPFRYIHARIRGFFQELKQASAETHRTCIQGKFGISVLGLDAHTARMAVTHSVQAILEQGEEGEAQRIRFFDTQLHRQIKKRRLLEELVTDAIRNQSLLVEFQPIIDTRLGQVMSYEALCRFPLPAALEVSNSELISIAEDLDLITELDLQVQQQALRQWPILQAQHEYPIWLTVNISPNTRQGLPALIQCLRQLMASEQVPAERIIIDITQAKYHSQALVRSDALQELRQLGVQIAIDDMGTDYSLFEHLSASDFDYLKISRSCIDGLGNQTNRYQVIKMLVEMCHSLGVKVIAEGVESEEEAQLLVFGRLDYLQGFYFAKPLAMDDLLAFIESTLPQRLQLIAPQEENLSANSLMSLHHAHSPRLDPGDPISLAYQYFQSADVEVLPVIIEQECVGLVDRARLNLHLTPGMGSELETMKEASMWHRPVNQVMELTFTSIDAAIDVSQIPLLIREHHLGFPWILTKGKIYKGILTQSVILQYLVEQPQSVDFMI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

611586 : 618129

Staphylococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_038157346.1\|611586_612720_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	6.2e-65	42.0
WP_075988227.1\|612731_613982_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	1.2e-96	48.2
WP_020331649.1\|614084_614534_+	transcriptional regulator NrdR	NA	NA	NA	NA
WP_075988228.1\|614547_615657_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	3.8e-43	35.0
WP_044363789.1\|615660_616314_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	3.0e-35	39.5
WP_020431928.1\|616355_617465_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	4.8e-62	39.0
WP_075988229.1\|617658_618129_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	2.4e-31	46.7

DBSCAN-SWA_2

1531836 : 1542472

Vibrio_phage(88.89%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_075989227.1\|1531836_1533567_+	response regulator	A0A1V0SGX0	Hokovirus	5.6e-49	34.5
WP_075988574.1\|1534521_1534890_-	hypothetical protein	A0A1W6UGD7	Vibrio_phage	9.4e-39	62.2
WP_020432292.1\|1535071_1537129_+	replication endonuclease	R9TE46	Vibrio_phage	3.5e-260	66.5
WP_020432290.1\|1537183_1537498_+	hypothetical protein	R9TIT5	Vibrio_phage	8.3e-36	67.3
WP_020432284.1\|1537765_1537987_+	hypothetical protein	R9TI50	Vibrio_phage	1.1e-13	65.6
WP_155761265.1\|1538073_1539825_+	hypothetical protein	R9TE48	Vibrio_phage	6.5e-37	45.1
WP_075988576.1\|1539829_1540201_+	hypothetical protein	R9TIT8	Vibrio_phage	7.3e-39	63.9
WP_075988577.1\|1540200_1541274_+	hypothetical protein	O80263	Vibrio_phage	1.3e-152	70.4
WP_075988578.1\|1541254_1542472_+	type II secretory pathway protein	R9TEZ5	Vibrio_phage	3.1e-155	68.7

DBSCAN-SWA_3

2341239 : 2348287

Megavirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020330651.1\|2341239_2341671_-	nucleoside-diphosphate kinase	K7YW26	Megavirus	2.6e-19	39.8
WP_020330650.1\|2341740_2343033_-	aminopeptidase PepB	Q6GYZ8	Mycoplasma_phage	4.5e-35	40.7
WP_020330649.1\|2343209_2343404_-	Fe-S cluster assembly protein IscX	NA	NA	NA	NA
WP_020330648.1\|2343459_2343798_-	ISC system 2Fe-2S type ferredoxin	NA	NA	NA	NA
WP_075988849.1\|2343811_2345665_-	Fe-S protein assembly chaperone HscA	A0A0N9QXN8	Chrysochromulina_ericina_virus	1.2e-110	40.4
WP_020330646.1\|2345686_2346202_-	co-chaperone HscB	NA	NA	NA	NA
WP_020330645.1\|2346269_2346593_-	iron-sulfur cluster assembly protein IscA	A0A2H4N7N5	Lake_Baikal_phage	5.5e-27	54.2
WP_020330644.1\|2346652_2347036_-	Fe-S cluster assembly scaffold IscU	A0A218MKD1	uncultured_virus	9.1e-53	77.4
WP_075988850.1\|2347072_2348287_-	IscS subfamily cysteine desulfurase	A0A0H3TPH2	Faustovirus	1.1e-30	30.5

DBSCAN-SWA_4

2558689 : 2569795

uncultured_Mediterranean_phage(25.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_075988937.1\|2558689_2561272_-\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	2.9e-78	38.7
WP_075988938.1\|2561459_2561918_-	recombination regulator RecX	NA	NA	NA	NA
WP_024374201.1\|2561987_2563040_-	recombinase RecA	A0A2D1GPX2	Mycobacterium_phage	4.8e-112	60.7
WP_020330432.1\|2563212_2563701_-	nicotinamide-nucleotide amidase	B5TK85	Pseudomonas_phage	1.3e-24	44.5
WP_075988939.1\|2563785_2566347_+	DNA mismatch repair protein MutS	A0A1V0SC35	Catovirus	4.4e-34	23.4
WP_020429689.1\|2566415_2567402_-	RNA polymerase sigma factor RpoS	F4YCU2	Synechococcus_phage	1.3e-34	34.5
WP_075988940.1\|2567473_2568409_-	murein hydrolase activator NlpD	I3PV79	Clostridium_phage	6.6e-12	32.0
WP_020429685.1\|2568408_2569035_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	2.0e-36	53.3
WP_075988941.1\|2569027_2569795_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	9.1e-68	52.8

DBSCAN-SWA_5

2868743 : 2875407

Enterobacteria_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_075989065.1\|2868743_2869292_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	1.2e-50	61.2
WP_075989066.1\|2869297_2870170_-	dTDP-4-dehydrorhamnose reductase	A0A1D7XFA3	Escherichia_phage	1.1e-37	37.0
WP_075989067.1\|2870182_2871046_-	glucose-1-phosphate thymidylyltransferase RfbA	K7QKA7	Escherichia_phage	7.7e-108	67.7
WP_075989068.1\|2871048_2872113_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	6.6e-101	53.4
WP_075989069.1\|2872394_2873810_-	sulfate adenylyltransferase subunit CysN	A0A1V0SGC3	Hokovirus	5.2e-37	30.8
WP_075989070.1\|2873818_2874784_-	acetyltransferase	NA	NA	NA	NA
WP_075989071.1\|2874783_2875407_-	adenylyl-sulfate kinase	A0A1B0XTK9	Freshwater_phage	2.7e-09	43.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP019119

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CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP019118

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection